C191	Combination_Chemotherapy	Chemotherapy	Combination Chemotherapy|Chemotherapy, Combination|Combination Drug Therapy|Drug Therapy, Combination|combination chemotherapy	Treatment using more than one anticancer drug.
C192	Mesna	Uroprotective_Agent	Mesna|2-Mercaptoethanesulfonate, Sodium Salt|2-Mercaptoethanesulfonic Acid Sodium Salt|Ausobronc|D-7093|Filesna|MESNA|Mercaptoethane Sulfonate|Mercaptoethanesulfonate|Mesnex|Mesnil|Mesnum|Mexan|Mistabron|Mistabronco|Mitexan|Mucofluid|Mucolene|Sodium 2-Mercaptoethane Sulfonate|Sodium 2-Mercaptoethanesulphonate|UCB 3983|Uromitexan|Ziken|mesna	A drug that helps protect the kidneys and bladder from the toxic effects of anticancer drugs such as ifosfamide and cyclophosphamide.
C193	_3-Deazauridine	Cytidine_Triphosphate_Synthetase_Inhibitor|Pyrimidine_Antagonist	3-Deazauridine|2(1H)-pyridinone, 4-hydroxy-1-beta-D-ribofuranosyl|4-hydroxy-1-(beta-D-ribopentofuranosyl)-2-pyridone|Deazauridine	A synthetic analogue of nucleoside uridine lacking a ring nitrogen in the 3-position.  3-deazauridine inhibits cytidine synthase, thereby reducing intracellular levels of cytidine and deoxycytidine and disrupting DNA and RNA synthesis. This agent may trigger apoptosis and enhance differentiation of neoplastic cells.. (NCI04)
C194	_4-Nitroquinoline-1-Oxide	Heterocyclic_Compound	4-Nitroquinoline-1-Oxide|4-Nitroquinoline N-oxide	A potent mutagen and carcinogen. This compound and its metabolite 4-hydroxyaminoquinoline-1-oxide bind to nucleic acids. It inactivates bacteria but not bacteriophage. (MeSH)
C195	Mercaptopurine	Immunosuppressant|Purine_Antagonist	Mercaptopurine|1,7-Dihydro-6H-purine-6-thione|1,7-Dihydro-6H-purine-6-thione Monohydrate|3H-Purine-6-thiol|6 MP|6 Thiohypoxanthine|6 Thiopurine|6-MP|6-Mercaptopurine|6-Mercaptopurine Monohydrate|6-Purinethiol|6-Thiopurine|6-Thioxopurine|6H-Purine-6-thione, 1,7-dihydro- (9CI)|7-Mercapto-1,3,4,6-tetrazaindene|Alti-Mercaptopurine|Azathiopurine|BW 57-323H|Bw 57-323H|Flocofil|Ismipur|Leukerin|Leupurin|MERCAPTOPURINE|Mercaleukim|Mercaleukin|Mercaptina|Mercapto-6-purine|Mercaptopurinum|Mercapurin|Mern|NCI-C04886|NSC 755|Puri-Nethol|Purimethol|Purine, 6-mercapto-|Purine-6-thiol (8CI)|Purine-6-thiol Monohydrate|Purine-6-thiol, Monohydrate|Purine-6-thiol, monohydrate|Purinethiol|Purinethol|U-4748|WR-2785|mercaptopurine	A thiopurine-derivative antimetabolite with antineoplastic and immunosuppressive activities.  Produced through the metabolism of mercaptopurine by hypoxanthine-guanine phosphoribosyltransferase (HGPRT), mercaptopurine metabolites 6-thioguanosine-5'-phosphate (6-thioGMP) and 6-thioinosine (T-IMP) inhibit nucleotide interconversions and de novo purine synthesis, thereby blocking the formation of purine nucleotides and inhibiting DNA synthesis.  This agent is also incorporated into DNA in the form of deoxythioguanosine, which results in the disruption of DNA replication. In addition, mercaptopurine is converted to 6-methylmercaptopurine ribonucleoside (MMPR) by 6-thiopurine methyltransferase; MMPRs are also potent inhibitors of de novo purine synthesis. (NCI04)
C196	Benzo_a_pyrene-7_8-diol_9_10-Epoxide	DNA_Adduct_Forming_Agent|Intercalating_Agent	Benzo(a)pyrene-7,8-diol 9,10-Epoxide|BPDE	A benzopyrene derivative with carcinogenic and mutagenic activity. (MeSH)
C197	Dimethylbenzanthracene	Polycyclic_Aromatic_Hydrocarbons	Dimethylbenzanthracene|1,4-Dimethyl-2,3-benzphenanthrene|7,12-Dimethylbenz(a)anthracene|7,12-Dimethylbenzanthracene|9,10-Dimethyl-1,2-Benzanthracene|DMBA	A polycyclic aromatic hydrocarbon produced during combustion of fuels exhibiting carcinogenic activity.  In addition, dimethylbenzanthracene is found in tobacco smoke. (NCI)
C198	Acetaminophen	Analgesic_and_Antipyretic	Acetaminophen|4-Hydroxyacetanilide|ACETAMINOPHEN|APAP|N-(4-Hydroxyphenyl)acetamide|Paracetamol|Tylenol|acetaminophen	A drug that reduces pain and fever (but not inflammation).  It belongs to the family of drugs called analgesics.
C199	Acetyl_Coenzyme_A	Coenzyme_A	Acetyl Coenzyme A|Acetyl-CoA	The condensation product of coenzyme A and acetic acid which participates in the biosynthesis of fatty acids and sterols, in the oxidation of fatty acids and in the metabolism of many amino acids.  In addition, Acetyl Coenzyme A acts as a biological acetylating agent. (NCI)
C200	Acetylcysteine	Cysteine	Acetylcysteine|ACETYLCYSTEINE|Airbron|Broncholysin|Brunac|Fabrol|Fluatox|Fluimucetin|Fluimucil|Fluprowit|L-Alpha-acetamido-beta-mercaptopropionic Acid|Muco Sanigen|Mucocedyl|Mucolator|Mucolyticum|Mucomyst|Mucosolvin|Mucret|N-Acetyl Cysteine|N-Acetyl-L-cysteine|N-Acetylcysteine|N-acetyl-3-mercaptoalanine|N-acetyl-L-cysteine|N-acetylcysteine|NAC|Neo-Fluimucil|Parvolex|Respaire|Tixair|acetylcysteine	A drug usually used to reduce the thickness of mucus and ease its removal. It is also used to reverse the toxicity of high doses of acetaminophen. Also called N-acetyl-L-cysteine.
C201	Muramyl_Dipeptide	Peptide	Muramyl Dipeptide	A naturally occurring component of bacterial cell walls that has the capacity to activate macrophages.
C202	Aclarubicin	Aclacinomycin_Antibiotic	Aclarubicin|1-naphthacenecarboxylic acid, 2-ethyl-1,2,3,4,6,11-hexahydro-2,5, 7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-((2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl) -.alpha.-L-lyxo-hexopyranosyl]-3-(dimethylamino)-.alpha.-L-lyxo-hexopyranosyl]oxy]-, methyl ester,(1R-(1.alpha.,2.beta.,4.beta.))-(9CI)|Aclacin|Aclacinomycin|Aclacinomycin A|Aclacinomycin A hydrochloride|Aclacinomycin-A|Aclacinomycine|Aclacinon|Aclaplastin|Aclarubicin HCl|Aclarubicin Hydrochloride|Antibiotic MA144-A1|Jaclacin|MA144-A1|NSC 208734|[1R-(1alpha,2beta,4beta)]-2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydeo-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranosyl]-3-(dimethylamino-alpha-L-lyxo-hexopyranosyl)oxy]-|[1R-(1alpha,2beta,4beta)]-2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-4-[[2,3,6-trideoxy-4-O-[2,6-dideoxy-4-O-[(2R-trans)-tetrahydro-6-methyl-5-oxo-2H-pyran-2-yl]-alpha-L-lyxo-hexopyranosyl]-3-(dimethylamino-alpha-L-lyxo-hexopyranosyl)oxy]-1-naphthacenecarboxylic acid methyl ester	An oligosaccharide anthracycline antineoplastic antibiotic isolated form the bacterium Streptomyces galilaeus.  Aclarubicin intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  Aclarubicin is antagonistic to other agents that inhibit topoisomerase II, such as etoposide, teniposide and amsacrine.  This agent is less cardiotoxic than doxorubicin and daunorubicin. (NCI04)
C203	Acridine	Intercalating_Agent	Acridine
C204	Actinomycin_Antibiotic	Antineoplastic_Antibiotic|DNA_Minor_Groove_Binding_Agent	Actinomycin Antibiotic|Actinomycins	A class of chromopeptide antineoplastic antibiotics isolated from the bacterial genus Streptomyces.  Actinomycin antibiotics inhibit DNA replication and RNA and protein synthesis by various mechanisms such as intercalating into the minor groove of DNA or binding to topoisomerase II. (NCI04)
C205	Acyclovir	Nucleic_Acid_Synthesis_Inhibitor	Acyclovir|2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one|9-[(2-Hydroxyethoxy)-methyl]guanine|9-[(2-Hydroxyethoxy)methyl]guanine|ACYCLOVIR|Acicloftal|Aclovir|Acycloguanosine|BW-248U|Cargosil|acyclovir	A synthetic analog of the purine nucleoside, guanosine, with potent antiviral activity against herpes simplex viruses type 1 and 2, varicella-zoster virus and other viruses.  After conversion in vitro to the active metabolite acyclovir triphosphate, acyclovir competitively inhibits viral DNA polymerase, incorporates into and terminates the growing viral DNA chain, and inactivates viral DNA polymerase. The greater antiviral activity of acyclovir against HSV compared to VZV is due to its more efficient phosphorylation by the thymidine kinase of HSV. (NCI04)
C206	Adenine	Purine	Adenine|1H-Purin-6-amine	A purine base and a fundamental unit of adenine nucleotides. (MeSH)
C207	Adenosine	Nucleoside	Adenosine|ADENOSINE	A nucleoside that is composed of adenine and d-ribose. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. (MeSH)
C208	Cyclic_AMP	Intracellular_Second_Messenger	Cyclic AMP|3'5'-cyclic ester of AMP|Adenosine Cyclic 3',5'-(Hydrogen Phosphate)|Adenosine Cyclic 3':5'-Monophosphate|Cyclic Adenosine Monophosphate|cAMP	An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH. (MeSH)
C209	Adenosine_Triphosphate	Nucleotides	Adenosine Triphosphate|ATP|adenosine triphosphate	Adenosine triphosphate.  A substance present in all living cells that provides energy for many metabolic processes and is involved in making RNA.  ATP made in the laboratory is being studied in patients with advanced solid tumors to see if it can decrease weight loss and improve muscle strength.
C210	Immunoadjuvant	Biological_Response_Modifier	Immunoadjuvant|Adjuvants, Immunologic|Immunologic Adjuvant|Immunologic Adjuvants|immune adjuvant|immunological adjuvant	A drug that stimulates the immune system to respond to disease.
C211	Therapeutic_Corticosteroid	Adrenal_Agent|Immunosuppressant	Therapeutic Corticosteroid|Corticosteroids|corticosteroids	Hormones that have antitumor activity in lymphomas and lymphoid leukemias; in addition, corticosteroids (steroids) may be used for hormone replacement and for the management of some of the complications of cancer and its treatment.
C212	Therapeutic_Corticotropin	Pituitary_Agent	Recombinant Corticotropin|ACTH|Acthar|Adrenocorticotropic Hormone|Adrenocorticotropin|Corticotropin|Corticotropin (ACTH)|Therapeutic ACTH	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous open-chain polypeptide hormone corticotropin, also known as adrenocorticotropic hormone (ACTH).  Secreted by the anterior pituitary gland endogenously, circulating ACTH stimulates the adrenal cortex to secrete adrenocortical steroids, especially cortisone.  With normally functioning adrenal glands, ACTH exerts pharmacologic effects similar to those of cortisone.
C213	Aflatoxin	Mycotoxin	Aflatoxin|aflatoxins	(AF-la-TOK-sins) Harmful substances made by certain types of mold (Aspergillus flavus and Aspergillus parasiticus) that are often found on poorly stored grains and nuts. Consumption of foods contaminated with aflatoxins is a risk factor for primary liver cancer.
C214	Albumin	Drug_Vehicle	Albumin|ALB	A family of globular proteins found in many plant and animal tissues that tend to bind a wide variety of ligands.  Albumin is the main protein in blood plasma.  Low serum levels occur in conditions associated with malnutrition, inflammation and liver and kidney diseases. (NCI)
C215	Albuterol	Bronchodilator	Albuterol|ALBUTEROL	A racemic mixture with a 1:1 ratio of the r-isomer, levalbuterol, and s-albuterol. It is a short-acting beta2-adrenergic agonist with its main clinical use in asthma. (MeSH)
C216	Ethanol	Retired_Concepts	Ethanol|Absolute Ethanol|Alcohol	A colorless organic liquid also known as ethyl alcohol or grain alcohol.  Ethanol's primary physiologic effects involve the central nervous system.  Depending on the dose delivered, ethanol behaves as an anxiolytic, a depressant, or a general anesthetic.  Ethanol-induced immunosuppression involves dysregulation of CD4+ T cells. (NCI04)
C217	Methanol	Alcohol_Chemical_Class	Methanol|METHANOL|Methyl Alcohol|Wood Alcohol	Used as a solvent and as an intermediate in chemical synthesis.  Component of deicing mixtures and preservatives. Toxic.
C218	Alcohol_Chemical_Class	Organic_Chemical	Alcohol [Chemical Class]|Alcohols	A class of compounds where a hydroxyl (OH) group is attached to single bonded hydrocarbons.  Alcohols are classified according to the position of the carbon atom with the attached hydroxyl group (i.e. primary alcohols are alcohols with the OH group attached to the primary carbon atom, C1).  Uses include solvents, astringents, and anti-infective activity.(NCI)
C219	Aldosterone	Mineralocorticoid	Aldosterone|(+)-Aldosterone	A hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. (MeSH)
C220	Alfentanil_Hydrochloride	Opioid	Alfentanil Hydrochloride|ALFENTANIL HYDROCHLORIDE|Alfenta|Rapifen	An ultra short-acting narcotic analgesic with unknown mechanism of action that binds to the opiate receptors in the central nervous system and changes the perception of and emotional response to pain. It also has local anesthetic effects. (NCI)
C221	Alkaloid	Organic_Chemical	Alkaloid|Alkaloids|alkaloid	A family or group of nitrogen-containing base compounds primarily derived from plant and animal sources.  Many alkaloids are used medicinally, including cancer therapy. (NCI)
C222	Alkylsulfonate_Compound	Antineoplastic_Alkylating_Agent	Alkylsulfonate Compound|Alkanesulfonates|Alkyl Sulfonates|Sulfonates	Organic esters or salts of sulfonic acid derivatives containing an aliphatic hydrocarbon radical. (MeSH)
C223	Alkylating_Agent	Chemical_Modifier	Alkylating Agent|Alkylating Agents|Alkylator|alkylating agents	A family of anticancer drugs that interferes with the cell's DNA and inhibits cancer cell growth.
C224	Allopurinol	Uricosuric_Agent|Xanthine_Oxidase_Inhibitor	Allopurinol|1,5-Dihydro-4H-pyrazolo[3,4-d]pryimidin-4-one|1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one|1H-Pyrazolo[3,4-d]pyrimidin-4-ol|4-Hydroxypyrazolo[3,4-d]pyrimidine|ALLOPURINOL|Sigapurol|allopurinol	A a structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. (NCI04)
C225	Therapeutic_Interferon_Alfa	Angiogenesis_Activator_Inhibitor|Therapeutic_Interferon	Recombinant Interferon Alfa|AFN|Alpha Interferon|G-Interferon|Ginterferon|Human Leukocyte Interferon-Lambert|Interferon Alpha (IFN-A)|Interferon alfa (IFN-A)|Leukocyte Interferon|Lymphoblast Interferon|Lymphoblastoid Interferon|Purified Lymphoblastoid Interferon	A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents.  Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products.  These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element.  The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04)
C226	Eflornithine	Chemopreventive_Agent|Ornithine_Decarboxylase_Inhibitor	Difluoromethylornithine|2-(Difluoromethyl)-DL-ornithine|2-Difluoromethylornithine|Alpha-Difluoromethylornithine|D,L-alpha-Difluoromethylornithine|DFMO|Eflornithine|Eflornithine (DFMO ORNIDYL)|MDL 71782|Ornidyl|RMI-71782|difluoromethylornithine|eflornithine	A difluoromethylated ornithine compound with antineoplastic activity.  Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04)
C227	Alprazolam	Benzodiazepine	Alprazolam|ALPRAZOLAM|Apo-Alpzar|Nu-Alpraz|Xanax	A triazolo benzodiazepine agent with antianxiety and sedative-hypnotic activities. The exact mechanism of action is unknown but it affects the limbic, thalamic and hypothalamic regions of the CNS. (NCI)
C228	Alum_Adjuvant	Vaccine_Adjuvant	Alum Adjuvant|Aluminum Sulfate|alum|aluminum sulfate	A type of immune adjuvant (a substance used to help boost the immune response to a vaccine).
C229	Americium	Radioactive_Element	Americium	A man-made radioactive element with atomic symbol Am, atomic number 95, and atomic weight 243.
C230	Amikacin	Aminoglycoside_Antibiotic	Amikacin Sulfate|AMIKACIN SULFATE|Amikacin|Amikin|amikacin	A broad-spectrum antibiotic derived from kanamycin. It is reno- and ototoxic like the other aminoglycoside antibiotics. (MeSH)
C231	Amino_Acid	Amino_Acid_Peptide_or_Protein	Amino Acid|aa	Organic compounds containing amino (-NH2) and carboxyl (-COOH) groups.  In biochemistry, used to refer to the twenty-plus L-alpha-amino acids found in proteins.
C232	Amino_Acid_Peptide_or_Protein	Organic_Chemical	Amino Acid, Peptide, or Protein	Amino acids and chains of amino acids connected by peptide linkages.
C233	Aminoglutethimide	Anti-Adrenal|Non-Steroidal_Aromatase_Inhibitor	Aminoglutethimide|2-(p-Aminophenyl)-2-ethylglutarimide|3-(4-Aminophenyl)-3-ethyl-2,6-piperidinedione|3-Ethyl-3-(p-aminophenyl)-2,6-dioxopiperidine|AMINOGLUTETHIMIDE|Aminoblastin|BA-16038|Ba-16038|Cytadren|Cytardren|Elipten|Mamomit|Orimenten|Orimeten|Orimetene|Rodazol|alpha-(4-Aminophenyl)-alpha-ethylglutarimide|aminoglutethimide	A synthetic derivative of the sedative and anticonvulsant glutethimide with anti-steroid properties.  Originally used as an anticonvulsant, aminoglutethimide also blocks adrenal steroidogenesis by inhibiting the enzymatic conversion of cholesterol to pregnenolone.  In addition, this agent blocks the peripheral aromatization of androgenic precursors to estrogens.  Aminoglutethimide does not suppress ovarian estrogen production.
C234	Aminolevulinic_Acid	Photosensitizing_Agent	Aminolevulinic Acid|5-ALA|5-Amino-4-oxopentanoic Acid|5-Aminolaevulinic Acid|5-Aminolevulinic Acid|Amino-Levulinic Acid|Delta Aminolevulinic Acid|Delta-Aminolevulinic Acid|Levulan|aminolevulinic acid|d-Amino-Levulinic Acid	A drug used in photodynamic therapy that is absorbed by tumor cells; when exposed to light, it becomes active and kills the cancer cells.
C235	Aminopterin	Dihydrofolate_Reductase_Inhibitor|Folate_Antagonist	Aminopterin|4-Aminofolic Acid|4-Aminofolic acid|4-Aminopteroylglutamic Acid|4-Aminopteroylglutamic acid|APGA|Aminopterin Sodium|Aminopteroylglutamic Acid|aminopterin	A synthetic derivative of pterins with antineoplastic and immunosuppressive properties.  As a folate analogue, aminopterin competes for the folate binding site of the enzyme dihydrofolate reductase, thereby blocking tetrahydrofolate synthesis, and resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. (NCI04)
C236	Amiodarone	Multidrug_Resistance_Modulator	Amiodarone Hydrochloride|AMIODARONE HYDROCHLORIDE|Amiodarone	An iodine-rich benzofuran derivative with antianginal and antiarrhythmic activity.  Amiodarone blocks the calcium, potassium and sodium channels, resulting in prolonged cardiac action potential and refracatory period.  In addition, amiodarone exerts a noncompetitive alpha- and beta-adrenergic inhibition which is partially responsible for the negative dromotropic effects. (NCI)
C237	Amoxicillin	Penicillin_Antibiotic	Amoxicillin|AMOXICILLIN|Amoxil|Polymox|Trimox|Utimox|Wymox|amoxicillin	A broad-spectrum semisynthetic antibiotic, similar to ampicillin but more resistance to gastric acids, that inhibits bacterial cell wall synthesis by binding to penicillin binding proteins and inhibiting peptidoglycan synthesis, a critical component of bacterial cell walls. (NCI)
C238	Amphotercin_B	Antifungal_Agent	Amphotercin B|AmB|Amphocil|Amphotec|Amphotercin B Deoxycholate|Amphotercin-B|Amphotericin B|Amphotericin b|Fungizone|amphotericin B	A macrolide antifungal antibiotic produced by Streptomyces nodosus that binds to ergosterol altering cell membrane integrity with subsequent cell death. (NCI)
C239	Ampicillin	Penicillin_Antibiotic	Ampicillin|(2S,5R,6R)-6-((R)-2-Amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid|AMPICILLIN	A broad-spectrum semisynthetic derivative of aminopenicillin that inhibits bacterial cell wall synthesis by binding to penicillin binding proteins and inhibiting peptidoglycan synthesis, a critical component of bacterial cell wall. (NCI)
C240	Amsacrine	Acridine|DNA_Minor_Groove_Binding_Agent|Topoisomerase-II_Inhibitor	Amsacrine|4'-(9-Acridinylamino)methane-sulfon-m-anisidide|AMSA|Acridinyl Anisidide|Amekrin|Amsa P-D|Amsidine|Amsidyl|CI-880|Cain's Acridine|Lamasine|N-[4-(9-Acridinylamino)-3-methoxyphenyl]methanesulfonamide|SN 11841|SN-11841|amsacrine|m-AMSA	An aminoacridine derivative with potent antineoplastic properties. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks. This agent's cytotoxicity is maximal during the S phase of the cell cycle when topoisomerase levels are greatest.
C241	Analgesic_Agent	Pharmacologic_Substance	Analgesic Agent|ANALS|Analgesic Drugs|Analgesics|Anodynes|Antinociceptive Agents|analgesics	Compounds that alleviate pain without loss of consciousness.  Analgesics act by various mechanisms including binding with opioid receptors and decreasing inflammation.  Choice of analgesic may be determined by the type of pain.  These compounds include opioid, non-opioid and adjuvant analgesic agents.(NCI)
C242	Anti-Androgen	Hormone_Antagonist	Anti-Androgen|Androgen Antagonists|Anti-Androgen Agents|Antiandrogen Agents|Antiandrogens|antiandrogens	(an-tee-AN-dro-jens) Drugs used to block the production or interfere with the action of male sex hormones.
C243	Therapeutic_Androgen	Therapeutic_Steroid_Hormone	Therapeutic Androgen|Androgens|androgens	A class of sex hormones associated with the development and maintenance of the secondary male sex characteristics, sperm induction, and sexual differentiation. In addition to increasing virility and libido, they also increase nitrogen and water retention and stimulate skeletal growth. (MeSH)
C244	Therapeutic_Androstenedione	Therapeutic_Androgen	Therapeutic Androstenedione|4-Androstene-3,17-dione|Delta-4-Androstenedione	A potent androgenic prohormone that is a direct precursor of testosterone and used as a supplement to increase plasma testosterone levels and muscle anabolism. (NCI)
C245	Anesthetic_Agent	Adjuvant_Analgesic	Anesthetic Agent|Anesthestic Drugs|Anesthetic Drugs|Anesthetics|anesthetics	(an-es-THET-iks) Substances that cause loss of feeling or awareness. Local anesthetics cause loss of feeling in a part of the body. General anesthetics put the person to sleep.
C246	Anethole_Trithione	Chemopreventive_Agent|Miscellaneous_Chemoprotective_Agent	Anethole Trithione|(p-Methoxyphenyl)trithiopropene|3-(p-Anisyl)-4,5-dithiacyclopent-2-ene-1-thione|3-(p-Anisyl)trithione|3-(p-Methoxyphenyl)-4,5-dithiacyclopent-2-ene-1-thione|3-(p-Methoxyphenyl)trithione|5-(4-Methoxyphenyl)-3H-1,2-dithiole-3-thione|5-(p-Methoxyphenyl)-1,2-dithiacyclopent-4-ene-3-thione|5-(p-Methoxyphenyl)-3H-1,2-dithiole-3-thione|Anethole Dithiolthione|Anetholtrithione|Felviten|Heporal|Mucinol|Sialor|Sufralem|Sulfarlem|Tiotrifar|Trithio|Trithio-p-methoxyphenylpropene|Trithioanethol|anetholtrithione	A drug that may reduce the risk of development or progression of cancer.
C247	ACE_Inhibitor	Enzyme_Inhibitor	ACE Inhibitor|Angiotensin Converting Enzyme Inhibitor	A class of antihypertensive agents that inhibit angiotensin-converting enzyme (ACE), preventing conversion of angiotensin I to angiotensin II ultimately resulting in vasodilation and mild natriuresis.  In addition, ACE inhibitors increase prostaglandin synthesis which may play a role in their antihypertensive effects.
C248	Angiotensin	Peptide_Hormone	Angiotensin	Expressed in liver by human AGT Gene (Serpin Family), secreted 485-aa 53-kDa Angiotensinogen is cleaved by renin (in response to lowered blood pressure) to inactive decapeptide Angiotensin I, which is cleaved by ACE to generate active octapeptide vasopressor Angiotensin II (maintains blood pressure and regulates the volume and mineral balance of body fluids). Angiotensin II is cleaved to Angiotensin III heptapeptide, an aldosterone stimulant.
C249	Aniline_Mustard	Nitrogen_Mustard_Compound	Aniline Mustard|.beta.,.beta.'-Dichlorodiethylaniline|A 14489|Aniline mustard|Benzenamine, N, N-bis(2-chloroethyl)- (9CI)|Benzenamine, N, N-bis(2-chloroethyl)-(9CI)|CB 1074|Lymphochin|Lymphocin|Lymphoquin|Mesylerythrol|N, N-Bis(2-chloroethyl)aniline|N,N-bis(2-chloroethyl)aniline|N,N-bis(2-chloroethyl)benzenamine|NSC-18429|Phenylbis(2-chloroethylamine)|SK 592|TL 476|beta, beta'-dichlorodiethylaniline|mesylerythrol|phenylbis[2-chloroethylamine]	An alkylating mustard with antineoplastic activity. Aniline mustard forms covalent linkages with nucleophilic centers, resulting in depurination, base miscoding and strand scission, and crosslinking of DNA strands, all of which contribute to its cytotoxicity. (NCI04)
C250	Antihelminthic_Agent	Antiparasitic_Agent	Antihelminthic Agent|Antihelminthic Drugs|Antihelminthics|Vermifuges	Agents destructive to parasitic worms. They are used therapeutically in the treatment of helminthiasis in man and animal. (MeSH)
C251	Anthracene	Polycyclic_Aromatic_Hydrocarbons	Anthracene|ANTHRACENE|Anthracin|Green Oil|Paranaphthalene|Tetra Olive N2G	Anthracene, also called paranaphthalene or green oil, a solid polycyclic aromatic hydrocarbon (PAH) consisting of three benzene rings derived from coal-tar, is the simplest tricyclic aromatic hydrocarbon.  It is on the EPA's priority pollutant list. It is ubiquitous in the environment as a product of incomplete combustion of fossil fuels. It has been identified in surface and drinking water, ambient air, exhaust emissions, smoke of cigarettes and cigars, and in smoked foods and edible aquatic organisms. It is primarily used as an intermediate in the production of dyes, smoke screens, scintillation counter crystals, and in organic semiconductor research. Although a large body of literature exists on the toxicity of PAHs, data for anthracene are limited. Prolonged exposure causes variety of topical and systemic adverse reactions. Carcinogenicity bioassays with anthracene generally gave negative results. (NCI)
C252	Anthramycin	DNA_Minor_Groove_Binding_Agent|Miscellaneous_Antineoplastic_Antibiotic	Anthramycin|3-(5,10,11,11a-tetrahydro-9,11-dihydroxy-8-methyl-5-oxo-1h-pyrrolo(2,1-c)(1,4)benzodiazepin-2-yl)-2-propenamide	A pyrrolo(1,4)benzodiazepine antineoplastic antibiotic isolated from the bacterium Streptomyces refuineus var. thermotolerans.  Anthramycin binds covalently to guanine in the minor groove of DNA, thereby inhibiting DNA replication and RNA and protein synthesis. (NCI04)
C253	Anthraquinone_Compound	Intercalating_Agent|Topoisomerase-II_Inhibitor	Anthraquinone Compound|Anthracenedione|Anthracenediones|Anthraquinones|anthracenediones|anthraquinones	A subgroup of antineoplastic antibiotics Quinone derivatives of anthracene that exhibit cytotoxic activity through the intercalation of DNA and inhibition of topoisomerase II, a key enzyme involved in DNA synthesis. (NCI)
C254	Anti-Infective_Agent	Pharmacologic_Substance	Anti-Infective Agent|Anti-Infective Agents|Anti-Infective Drugs|Anti-Infectives|AntiInfective Agents|AntiInfective Drugs|AntiInfectives	Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection. (MeSH)
C255	Urinary_Anti-Infective_Agent	Anti-Infective_Agent	Urinary Anti-Infective Agent	Substances capable of killing agents causing urinary tract infections or of preventing them from spreading. (MeSH)
C256	Anti-Inflammatory_Agent	Retired_Concepts	Anti-Inflammatory Agent|Anti-Inflammatories|Anti-Inflammatory Drugs|Antiinflammatories|Antiinflammatory Agents|Antiinflammatory Drugs	Substances that reduce or suppress inflammation.
C257	Nonsteroidal_Antiinflammatory_Drug	Analgesic_and_Antipyretic	Nonsteroidal Antiinflammatory Drug|NSAID|NSAIDs|nonsteroidal anti-inflammatory drugs	A group of drugs that decrease fever, swelling, pain, and redness.
C258	Antibiotic	Anti-Infective_Agent	Antibiotic|ABX|Antibacterial Agent|Antibiotic Agents|Antibiotic Drugs|Antibiotics|antibiotic	(an-tih-by-AH-tik) A drug used to treat infections caused by bacteria and other microorganisms.
C259	Antineoplastic_Antibiotic	Antineoplastic_Agent	Antineoplastic Antibiotic|Anticancer Antibiotic|Anticancer Antibiotics|Antineoplastic Antibiotics|Antitumor Antibiotic|Antitumor Antibiotics|anticancer antibiotics|antineoplastic antibiotics|antitumor antibiotics	A group of anticancer drugs that block cell growth by interfering with DNA, the genetic material in cells. Also called anticancer antibiotics or antitumor antibiotics.
C260	Beta-Lactam_Antibiotic	Antibiotic	Beta-Lactam Antibiotic|Lactam Antibiotics	Compounds containing a four-membered ring with an amide nitrogen and a keto group. This configuration includes bacteriostatic, cell-wall inhibiting antibiotics, such as penicillins and cephalosporins, their analogs and derivatives, such as the penem (or penam) compounds, clavulanic acids, and monobactams. They are substrates for and may act as inhibitors of bacterial beta-lactamases. (MeSH)
C261	Macrolide_Antibiotic	Antibiotic|Protein_Synthesis_Inhibitor	Macrolide Antibiotic|Macrolides	A group of antibiotics containing a macrocyclic lactone ring linked glycosidically to one or more sugar moieties. These antibiotics are produced by certain species of Streptomyces. They often inhibit protein synthesis by binding to the 50S subunits of 70S ribosomes. (MeSH)
C262	Monoclonal_Antibody_Therapeutic	Retired_Concepts	Monoclonal Antibody (Therapeutic)|MAb|Monoclonal Antibodies
C263	Anticoagulant_Agent	Adjuvant	Anticoagulant Agent|ACOAG|Anticoagulant|Anticoagulant Drugs|Anticoagulants|anticoagulant|blood thinner	A drug that helps prevent blood clots from forming. Also called a blood thinner.
C264	Anticonvulsant_Agent	Adjuvant	Anticonvulsant Agent|ACON|Anticonvulsant|Anticonvulsant Drugs|Anticonvulsants|anticonvulsants	(an-tee-kon-VUL-sants) Drugs that prevent, reduce, or stop convulsions or seizures.
C265	Antidepressant_Agent	Adjuvant_Analgesic	Antidepressant Agent|Antidepressant|Antidepressant Drugs|Antidepressants|antidepressant	A drug used to treat depression.
C266	Antidiarrheal_Agent	Adjuvant	Antidiarrheal Agent|Antidiarrhea Agents|Antidiarrhea Drugs|Antidiarrheal Drugs|Antidiarrheals|Antidiarrheas	Miscellaneous agents found useful in the symptomatic treatment of diarrhea. They have no effect on the agent(s) that cause diarrhea, but merely alleviate the condition. (MeSH)
C267	Antiemetic_Agent	Adjuvant	Antiemetic Agent|AEM|Antiemetic|Antiemetic Drugs|Antiemetics|antiemetics	Drugs that prevent or reduce nausea and vomiting.
C268	Antigen	Biological_Agent	Antigen|ATGN|Antigens|antigens	Any substance, generally a protein, that stimulates the immune system and elicits an immune response.  Recognition by the immune system elicits either a T-lymphocyte response, recognizing processed antigens, or a B-lymphocyte response, producing antibodies that bind to unprocessed antigens.(NCI)
C269	Cell_Surface_Antigen	Antigen	Cell Surface Antigen|Cell Surface Antigens	Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
C270	Antihypertensive_Agent	Adjuvant	Antihypertensive Agent|Antihypertensive Drugs|Antihypertensives|Hypotensive Agents|Hypotensive Drugs|Hypotensives	Drugs used in the treatment of acute or chronic hypertension regardless of pharmacological mechanism. Among the antihypertensive agents are diuretics, adrenergic beta-antagonists; andrenergic alpha-antogonists; angiotensin-converting enzyme inhibitors; calcium channel blockers; ganglionic blockers; and vasodilator agents. (MeSH)
C271	Antimalarial_Agent	Antiparasitic_Agent	Antimalarial Agent|Antimalarial Drugs|Antimalarials	Agents used to treat malaria, and are usually classified based on action against plasmodia at different stages in their life cycle in the human. (NCI)
C272	Antimetabolite	Antineoplastic_Agent	Antimetabolite|Antimetabolites|antimetabolite	A drug that is very similar to natural chemicals in a normal biochemical reaction in cells but different enough to interfere with the normal division and functions of cells.
C273	Antimitotic_Agent	Antineoplastic_Agent	Antimitotic Agent|Antimitotic Drugs|Antimitotics|Microtubular Function Inhibitors|Mitosis Inhibitor Agents|Mitosis Inhibitor Drugs|Mitosis Inhibitors|Mitotic Inhibitor Agents|Mitotic Inhibitor Drugs|Mitotic Inhibitors|mitotic inhibitors	Drugs that kill cancer cells by interfering with cell division (mitosis).
C274	Antineoplastic_Agent	Pharmacologic_Substance	Antineoplastic Agent|Anti-Cancer Agents|Anti-Tumor Agents|Anti-Tumor Drugs|Antineoplastic Drugs|Antineoplastics|Antiproliferative Agents|Antiproliferative Drugs|Cancer Drug|Chemotherapeutic Agents, Neoplastic Disease|Tumor-Specific Treatment Agents|antineoplastic|chemotherapeutic agent	A drug used to treat cancer.
C275	Antioxidant	Protective_Agent	Antioxidant|antioxidant	A group of organic or inorganic substances capable of preventing the genotoxic and carcinogenic effects of free-radical compounds.  Antioxidants bind to and neutralize ('scavenge') free radicals, thereby transforming them into non-toxic compounds and blocking their genotoxic and carcinogenic effects.  This class of agents includes the vitamins C and E, the carotenoids, and selenium.  Organic antioxidants are found in high concentrations in fruits, seeds and vegetables. (NCI04)
C276	Antiparasitic_Agent	Anti-Infective_Agent	Antiparasitic Agent|Antiparasitic|Antiparasitic Drugs|Antiparasitics|antiparasitics	Drugs used to treat bacterial and parasitic infections and some cancers.
C277	Antiprotozoal_Agent	Antiparasitic_Agent	Antiprotozoal Agent|Antiprotozoal Drugs	Substances that are destructive to protozoans. (MeSH)
C278	Antithymocyte_Globulin	Immunosuppressant	Antithymocyte Globulin|ATG|ATGAM|Anti-Thymocyte Globulin|Thymoglobulin|antithymocyte globulin	(an-tee-THIGH-mo-site GLOB-yoo-lin) A protein used to reduce the risk of or to treat graft-versus-host disease.
C279	Trichomonacide_Agent	Antiprotozoal_Agent	Trichomonacide Agent
C280	Antitubercular_Agent	Anti-Infective_Agent	Antitubercular Agent|antituberculosis	Having to do with a drug used to treat tuberculosis.
C281	Antiviral_Agent	Anti-Infective_Agent	Antiviral Agent|Antiviral|Antivirals|antivirals	Drugs used to treat infections caused by viruses.
C282	Arachidonic_Acid	Physiology-Regulatory_Factor	Arachidonic Acid|(all-Z)-5,8,11,14-Eicosatetraenoic Acid|Arachidonate	An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the
C283	Artificial_Sweetener	Dietary_Component	Artificial Sweetener	A sweetener is a food additive which duplicates the effect of sugar on the taste, but with fewer calories. They are also called sugar substitutes. (Wikipedia)
C284	Asbestos	Carcinogenic_Mineral|Mineral	Asbestos|asbestos	(as-BES-tus) A natural material that is made up of tiny fibers. The fibers can cause cancer.
C285	Ascorbic_Acid	Antioxidant|Water-Soluble_Vitamin	Ascorbic Acid|ASCORBIC ACID|Asorbicap|C Vitamin|C-Long|Ce-Vi-Sol|Cecon|Cenolate|Cetane|Cevalin|L-Ascorbic Acid|VIT C|Vitamin C|Vitamin-C	A natural water-soluble vitamin (Vitamin C). Ascorbic acid is a potent reducing and antioxidant agent that functions in fighting bacterial infections, in detoxifying reactions, and in the formation of collagen in fibrous tissue, teeth, bones, connective tissue, skin, and capillaries. Found in citrus and other fruits, and in vegetables, vitamin C cannot be produced or stored by humans and must be obtained in the diet. (NCI04)
C286	Asparaginase	Miscellaneous_Chemoprotective_Agent|Protein_Synthesis_Inhibitor	Asparaginase|ASP-1|Asparaginase Erwinia|Asparaginase II|Colaspase|Crasnitine|Cristanaspase|EC 3.5.1.1|Elspar|Erwinase|Erwinia Asparaginase|Kidrolase|L-ASP|L-Asnase|L-Asparaginase|L-Asparagine Amidohydrolase|L-Asparagine amidohydrolase|Laspar|Lcf-ASP|Leucogen|Leunase|MK-965|Paronal|Re-82-TAD-15|Serasa|asparaginase	An enzyme isolated from the bacterium Escherichia coli or the bacterium Erwinia carotovora. Asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting leukemic cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle.  This agent also induces apoptosis in tumor cells.  The E. carotovora-derived form of asparaginase is typically reserved for cases of asparaginase hypersensitivity. (NCI04)
C287	Acetylsalicylic_Acid	Cyclooxygenase_Inhibitor	Acetylsalicylic Acid|2-(Acetyloxy)benzoic Acid|ASA|ASPIRIN|Acetylsalicylic acid|Aspergum|Aspirin|Ecotrin|Empirin|Entericin|Extren|Measurin|aspirin	A drug that reduces pain, fever, inflammation, and blood clotting. Aspirin belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is also being studied in cancer prevention.
C288	Azacitidine	Pyrimidine_Antagonist	Azacitidine|4-Amino-1-beta-D-ribofuranosyl-1,3,5-triazin-2(1H)-one|5 AZC|5-AC|5-AZC|5-Aza-cytidine|5-Azacytidine|AZACITIDINE|Azacytidine|Azacytidine, 5-|Ladakamycin|Mylosar|U-18496|azacitidine	A pyrimidine nucleoside analogue of cytidine with antineoplastic activity. Azacitidine is incorporated into DNA, where it reversibly inhibits DNA methyltransferase, thereby blocking DNA methylation.  Hypomethylation of DNA by azacitidine may activate tumor suppressor genes silenced by hypermethylation, resulting in an antitumor effect. This agent is also incorporated into RNA, thereby disrupting normal RNA function and impairing tRNA cytosine-5-methyltransferase activity. (NCI04)
C289	Azaserine	Glutamine_Amidotransferase_Inhibitor|Purine_Antagonist	Azaserine|AZASERINE|CL-337|CN 15757|CN-15757|Cl 337|Diazoacetate (Ester) L-Serine|Diazoacetate(ester) L-serine|Diazoacetic Acid Ester with Serine|Diazoacetylserine|L-Azaserine|L-Diazoacetate(ester) serine|L-diazoacetate (ester) serine|L-serine diazoacetate (ester)|NSC-742|O-diazoacetyl-L-serine|P-165|Serine Diazoacetate|o-Diazoacetyl-L-serine	A naturally occurring serine derivative diazo compound with antineoplastic properties, Azaserine functions as a purine antagonist and glutamine analogue (glutamine amidotransferase inhibitor) that competitively inhibits pathways in which glutamine is metabolized. An antibiotic and antitumor agent, Azaserine is used in clinical studies as a potential antineoplastic agent. (NCI04)
C290	Azathioprine	Immunosuppressant|Inosine_5-Phosphate_Dehydrogenase_Inhibitor|Purine_Antagonist	Azathioprine|6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine|AZA|AZATHIOPRINE	6-(1-Methyl-4-nitro-5-imidazolyl)thiopurine; a derivative of 6-mercaptopurine, used as a cytotoxic and immunosuppressive agent in organ transplantation and in the treatment of autoimmune diseases such as hemolytic anemias, systemic lupus erythematosus, rheumatoid arthritis and leukemias.
C291	_6-Azauridine	Orotidylate_Decarboxylase_Inhibitor|Pyrimidine_Antagonist	6-Azauridine|1,2,4-triazine-3,5(2H,4H)-dione, 2-beta-D-ribofuranosyl|2-beta-D-ribofuranosyl-1,2,4-triazine-3,5(2H, 4H)-dione|2-beta-D-ribofuranosyl-1,2,4-triazine-3,5(2H,4H)-dione|3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine riboside|6-Azauracil 1-riboside|6-Azauracil riboside|6-Azauracil-.beta.-D-riboside|6-Azauracilriboside|6-azauracil 1-riboside|6-azauracil riboside|6-azauracil-.beta.-D-riboside|6-azauracilriboside|Azauridine|NSC 32074|NSC-32074|Riboazauracil	A synthetic triazine nucleoside derivative possessing antineoplastic and anti-psoriatic activity.  After metabolism to 6-azauridine-5-prime monophosphate, 6-Azauridine inhibits de novo pyrimidine biosynthesis and incorporates the 5-prime triphosphate metabolite into RNA, thereby preventing nucleic acid synthesis. (NCI04)
C292	Ethylenimine_Compound	Antineoplastic_Alkylating_Agent	Ethylenimine Compound|Azacyclopropanes|Aziridines|Dimethyleneimines
C293	Azlocillin	Penicillin_Antibiotic	Azlocillin|Azlin
C294	Azoxymethane	Nitrogen_Compound	Azoxymethane
C295	Bacitracin	Miscellaneous_Antibiotic	Bacitracin
C296	Bacterial_Toxin	Toxin	Bacterial Toxin|bacterial toxin	A toxic substance, made by bacteria, that can be modified to kill specific tumor cells without harming normal cells.
C297	Batrachotoxin	Neurotoxin	Batrachotoxin	Batrachotoxins are potent activators of sodium channels identified in extract of frog skins.
C298	BCG_Vaccine	Attenuated_Live_Virus_Vaccine	BCG Vaccine|BCG TICE|BCG Tice|BCG Vaccine - Connaught|BCG(Tice)|Bacille Calmette-Guerin Live|Bacillius Calmette Guerin Vaccine|Cultivo BCG|Immucyst|ImmunCyst|Imovax BCG|Live Intravesical BCG|Monovax|Oncotice|Pacis|Pastimmun|TICE BCG|TheraCys	An active immunizing agent (Bacille Calmette Guerin) against tuberculosis, BCG Vaccine usually contains a viable attenuated avirulent strain of Mycobacterium tuberculosis (var. bovis) that confers immunity to mycobacterial infections. Not widely used in the United States, BCG is often given to children where TB is common. Due to stimulation of antibody production and non-specific immunity, BCG is also used in cancer immunotherapy. (NCI04)
C299	Beclomethasone	Therapeutic_Glucocorticoid	Beclomethasone Dipropionate|(11beta,16beta)-9-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione|BECLOMETHASONE DIPROPIONATE|Beclomethasone|Beclovent|Beconase|Vancenase|Vanceril|beclomethasone	A drug being studied in the treatment of graft-versus-host disease.  It belongs to a family of drugs called corticosteroids.
C300	Diphenhydramine_Hydrochloride	Antiemetic_Agent|Histamine-1_Receptor_Antagonist	Diphenhydramine Hydrochloride|Benadryl|Bendylate|DIPHENHYDRAMINE HYDROCHLORIDE|Diphenhydramine HCl|Diphenhydramine hydrochloride|Diphenhydramine.HCl|Eldadryl|SK-Diphenhydramine
C301	Bence_Jones_Protein	Pathologic_Ab-Ig_Protein	Bence Jones Protein	Dimers of immunoglobulin light chains, normally produced by plasma cells. Bence Jones proteins are sufficiently small to be excreted by the kidney.  It is a characteristic protein found in the urine of most patients with multiple myeloma. It can be used to help in diagnosis of the disease and to monitor the response to treatment. (from On-line Medical Dictionary)
C302	Benzene	Aromatic_Compounds|Carcinogenic_Hydrocarbon	Benzene	A clear, colorless, highly flammable and volatile, liquid aromatic hydrocarbon with a gasoline-like odor. Benzene is found in crude oils and as a by-product of oil-refining processes. In industry benzene is used as a solvent, as a chemical intermediate, and is used in the synthesis of numerous chemicals. Exposure to this substance causes neurological symptoms and affects the bone marrow causing aplastic anemia, excessive bleeding and damage to the immune system. Benzene is a known human carcinogen and is linked to an increased risk of developing lymphatic and hematopoietic cancers, acute myelogenous leukemia, as well as chronic lymphocytic leukemia. (NCI05)
C303	Betamethasone	Therapeutic_Glucocorticoid	Betamethasone|BETAMETHASONE|Celestone
C304	Bile_Pigment	Pigment	Bile Pigment
C305	Bilirubin	Bile_Pigment	Bilirubin|BILI|BILIRUBIN|bilirubin	(bil-ih-ROO-bun) Substance formed when red blood cells are broken down. Bilirubin is part of the bile, which is made in the liver and is stored in the gallbladder. The abnormal buildup of bilirubin causes jaundice.
C306	Bioflavonoid	Antioxidant|Flavonoid	Bioflavonoid|Vitamin P Complex	Naturally occurring flavone or coumarin derivatives having the activity of the so-called vitamin P, notably rutin and esculin.
C307	Biological_Agent	Pharmacologic_Substance	Biological Agent|Biological Products|Biologicals|Biologics|Biopharmaceuticals|Immunologic, Immunochemical|Immunologics	Biotechnology-derived pharmaceutical agents made from living organisms or their products.  Includes recombinant proteins, monoclonal antibodies, and nucleic acids.
C308	Biological_Response_Modifier	Pharmacologic_Substance	Biological Response Modifier|BRM|Biological Response Modifiers|Biomodulators|Immune Mediators|Immune Mediators/Modulators|Immune Modulators|Immune Regulators|Immunomodulating Agent|Immunomodulators|Immunomodulatory Agent|Immunopotentiators|Immunotherapeutic Agent|biological response modifier	Substances or procedures that enhance the host's ability to inhibit tumorigenesis or tumor progression or that increase the differential between tumor and host susceptibility to therapeutic agents. Thus BRMs can be preventive (vaccines, vitamins) or therapeutic (interferon, monoclonal antibodies, hyperthermia, gene therapy.) Standard, nonspecific therapies such as drugs and radiation are excluded but radiation delivered via antibodies would be included since it exploits a differential susceptibility of tumor and host.
C309	Biotin	B_Vitamin	Biotin|(+)-Biotin|-(+)-Biotin|BIOTIN|Vitamin H	Hexahydro-2-oxo-1H-thieno(3,4-d)imidazole-4-pentanoic acid. Growth factor present in minute amounts in every living cell. It occurs mainly bound to proteins or polypeptides and is abundant in liver, kidney, pancreas, yeast, and milk. The biotin content of cancerous tissue is higher than that of normal tissue.
C310	Dicumarol	Coumarin	Dicumarol|3,3'-Methylenebis(4-hydroxy-2H-1-benzopyran-2-one)|Bishydroxycoumarin|Dicoumarol
C311	Bleomycin_A2	Bleomycin_Antibiotic	Bleomycin A2|BLEOMYCIN A2|n1-[3-(dimethylsulfonio)-propyl]bleomycinamide	The primary bleomycin species in bleomycin sulfate, a mixture of the sulfate salts of several basic glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus.  Bleomycin A2 forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. (NCI04)
C312	Bleomycin_Sulphate	Bleomycin	Bleomycin Sulphate|Blanoxan|BleMomycine|Blenoxane|Bleo-S|Bleo-cell|Bleocin|Bleolem|Bleomycin Sulfas|Bleomycin Sulfate|Bleomycin sulfate|Bleomycini Sulfas|Blexane|Oil Bleo	A mixture of the sulfate salts of basic glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus.  Bleomycin sulfate forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. (NCI04)
C313	Bleomycin	Bleomycin_Antibiotic	Bleomycin|BLEO|BLM|Bleo|bleomycin	A mixture of glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus.  Bleomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation. (NCI04)
C314	Blood_Substitute	Adjuvant	Blood Substitute
C315	Bombesin	Neurotransmitter	Bombesin
C316	Bradykinin	Neuropeptide	Bradykinin	A nonapeptide kinin and neuropeptide involved in blood pressure regulation and pain receptor stimulation.
C317	Bromocriptine	Neuroprotective_Agent	Bromocriptine Mesylate|2-Bromo-alpha-ergocryptine|BROMOCRIPTINE MESYLATE|Bromocriptine|Bromocryptine|Parlodel	Bromocriptine belongs to the group of medicines known as ergot alkaloids. It acts as a dopamine agonist primarily activating the dopamine D2 receptors. It blocks release of prolactin from the pituitary gland, and is used in the therapy of amenorrhea, infertility in women, abnormal breast milk discharge, hypogonadism, Parkinsons disease, and acromegaly. It is also used in the treatment of pituitary prolactinoma, neuroleptic malignant syndrome, cocaine addiction, and painful breast condition. (NCI)
C318	Bromodeoxyuridine	Radiosensitizing_Agent	Bromodeoxyuridine|5-BrdU|5-Bromo-2'-deoxyuridine|5-Bromodeoxyuridine|5-Bromouracil Deoxyriboside|5-Bromouracil deoxyriboside|5-Bromouracil-2-deoxyriboside|5-Budr|BRDU|BrdU|Bromodeoxyuridine (BUDR)|Bromouracil Deoxyriboside|Bromouracil deoxyriboside|Bromouridine|Broxine|Broxuridine|NSC 38297|Neomark|Neomark-BU|broxuridine	A drug that makes cancer cells more sensitive to radiation and is also used as a diagnostic agent to determine how fast cancer cells grow.
C319	Bronchodilator	Anti-asthmatic_Agent	Bronchodilator
C320	Buserelin	Gonadotropin-Releasing_Hormone_Analog	Buserelin|6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig)|6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing Hormone-releasing Factor (Pig)|BSRL|Bigonist|Buserelin Acetate|Busereline|D-Ser (Bu(t))(6) Pro(9) NEt LHRH Acetate|Etilamide|HOE 766|ICI 123215|Profact|Profact Depot|Receptal|S74-6766|Suprecur|Suprefact|Suprefact Depot|Suprefact Flakon|buserelin	A synthetic analog of gonadotropin-releasing hormone (GnRH).  Buserelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors.  Prolonged administration of buserelin results in sustained inhibition of gonadotropin production, suppression of testicular and ovarian steroidogenesis, and reduced levels of circulating gonadotropin and gonadal steroids. Buserelin is more potent that GnRH. (NCI04)
C321	Busulfan	Alkylsulfonate_Compound	Busulfan|1, 4-Bis[methanesulfonoxy]butane|1,4-Bis(methanesulfonoxy)butane|1,4-Bitanediol Dimethanesulfonate Esters|1,4-Butanediol Dimethylsulfonate|1,4-Di(methanesulfonyloxy)butane|1,4-Di(methylsulfonyloxy)butane|BUS|BUSULFAN|Bussulfam|Busulfanum|Busulfex|Busulphan|CB 2041|CB-2041|GT 41|GT-41|Glyzophrol|Joacamine|Methanesulfonic Acid Tetramethylene Ester|Methanesulfonic acid, tetramethylene ester|Mielucin|Misulban|Misulfan|Mitosan|Myeleukon|Myeloleukon|Myelosan|Mylecytan|Myleran|Sulfabutin|Tetramethylene Bis(methanesulfonate)|Tetramethylene bis[methanesulfonate]|WR-19508|busulfan	A synthetic derivative of dimethane-sulfonate with antineoplastic and cytotoxic properties.  Although its mechanism of action is not fully understood, busulfan appears to act through the alkylation of DNA.  Following systemic absorption of busulfan, carbonium ions are formed, resulting in DNA alkylation and DNA breaks and inhibition of DNA replication and RNA transcription. (NCI04)
C322	BHT	Antioxidant	BHT|2,6-Bis(1,1-dimethylethyl)-4-methylphenol|Butylated Hydroxytoluene|Butylated hydroxytoluene
C323	Butyrophenone	Antiemetic_Agent	Butyrophenone	Synthetic agents containing the phenyl-1-butanone group, most Butyrophenones are neuroleptic (antipsychotic) drugs, such as haloperidol, droperidol, or azaperone, that control schizophrenic symptoms (hallucinations, delusions, dementia). Most antipsychotic agents interfere with neurotransmitter functions, usually blocking dopamine receptors, and induce behavioral, endocrine, motor-kinetic effects. (NCI04)
C324	cDNA	Deoxyribonucleic_Acid	cDNA|CDNA|Copy DNA	Single-stranded DNA that is complementary to messenger RNA or DNA that has been synthesized from messenger RNA by reverse transcriptase.
C325	CA-125_Antigen	Tumor_Antigen	CA-125 Antigen|CA 125|CA-125|CA125|Cancer Antigen 125|Carbohydrate Antigen 125	A substance sometimes found in an increased amount in the blood, other body fluids, or tissues and that may suggest the presence of some types of cancer.
C326	Mucin_Peptide_MUC-1	Retired_Concepts	Mucin Peptide MUC-1|CA-15-3|CA15-3|CA15-3 Antigen|Cancer Antigen 15-3|Carbohydrate Antigen 15-3|Episialin|Muc1 Mucin|Polymorphic Epithelial Mucin	Mucin is expressed by most glandular epithelia.  Tandem repeats characterize the core mucin protein, apomucin; variation of the protein derives from variation in the number of expressed repeats.  Native forms of mucin are distinct in size and degree of glycosylation; factors other than the primary structure of apomucin may contribute to these characteristics.  Many complex O-linked oligosaccharides are presumably added by glycosyltransferases.  Expression is increased in the lactating breast and in breast, ovary, lung, and prostate malignancies.  It is a serum marker for breast cancer.  (NCI)
C327	CA19-9_Antigen	Tumor_Antigen	CA19-9 Antigen|CA-19-9|CA19-9|Cancer Antigen 19-9|Carbohydrate Antigen 19-9|Sialyl Lewis (A) Antigen	A carbohydrate antigenic moiety that consists of proteins with sialylated lacto-N-fucopentose II decoration. Cancer antigen 19-9 (CA 19-9) is a protein that exists on the surface of tumor cells, and is cleaved in a process called tumor shedding. Clinically, it is a useful protein marker that is used to follow the course of persons with cancer; and is especially utilized in advanced pancreatic cancers.
C328	Caffeine	Radiosensitizing_Agent	Caffeine|1,3,7-trimethylxanthine|3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione|CAFFEINE
C329	Therapeutic_Calcitonin	Adjuvant_Analgesic|Thyroid_Agent	Recombinant Calcitonin|Calcimar|Calcitonin|Calcitonin Salmon|Cibacalcin|Thyrocalcitonin|calcitonin	A hormone formed by the C cells of the thyroid gland. It helps maintain a healthy level of calcium in the blood.  When the calcium level is too high, calcitonin lowers it.
C330	Calcitriol	Vitamin_D	Calcitriol|(1alpha,3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol|1,25(OH)2-D3|1,25-Dihydroxycholecalciferol|CALCITRIOL|Rocaltrol|calcitriol	(kal-sih-TREE-ol) The active form of vitamin D.  Calcitriol is formed in the kidneys or made in the laboratory.  It is used as a drug to increase calcium levels in the body in order to treat skeletal and tissue-related calcium deficiencies caused by kidney or thyroid disorders.
C331	Calcium	Electrolytes|Element_or_Isotope|Intracellular_Second_Messenger	Calcium|CA|Calcium (NOS)|calcium	(KAL-see-um) A mineral found in teeth, bones, and other body tissues.
C332	Calcium_Carbonate	Chemopreventive_Agent	Calcium Carbonate|calcium carbonate	A mineral taken primarily as a supplement to prevent osteoporosis. It is also being studied for cancer prevention.
C333	Calcium_Channel_Blocker	Antihypertensive_Agent|Multidrug_Resistance_Modulator	Calcium Channel Blocker
C334	Edetate_Calcium_Disodium	Chelating_Agent	Edetate Calcium Disodium|C10H12CaN2Na2O8|Calcium Disodium Ethylenediaminetetraacetate|Calcium EDTA|Calcium disodium edetate|Calcium disodium ethylenediaminetetraacetate|Disodium calcium ethylenediaminetetraacetate|EDTA Calcium	Contracted name for a salt of ethylenediaminetetraacetate, an agent used as a chelator of lead and some other heavy metals. C10H12CaN2Na2O8.
C335	Calcium_Glucarate	Glucuronidase_Inhibitor	Calcium Glucarate	The calcium salt form of glucarate that converts to D-Glucaro-1,4-Lactone which inhibits beta-Glucuronidase, an enzyme that may prevent carcinogenesis. (NCI)
C336	Calcium_Gluconate	Nutritional_Supplement	Calcium Gluconate|Calcium D-gluconate|Calglucon	The gluconate salt of calcium. An element or mineral necessary for normal nerve, muscle, and cardiac function, calcium as the gluconate salt helps to maintain calcium balance and prevent bone loss when taken orally. This agent may also be chemopreventive for colon and other cancers. (NCI04)
C337	Calusterone	Anabolic_Steroid|Therapeutic_Androgen	Calusterone|17 Beta-OH-7 beta, 17 alpha-dimethyl-androst-4-ene-3-one|17-Beta-hydroxy-7-beta, 17-dimethylandrost-4-ene-3-one|7 Beta, 17 Alpha-dimethyltestosterone|7-.beta.-17-.alpha.-dimethyltestosterone|7.beta., 17.alpha.-Dimethyltestosterone|Androst-4-en-3-one, 17-hydroxy-7,17-dimethyl-, (7.beta., 17.beta.)- (9CI)|Androst-4-en-3-one, 17-hydroxy-7,17-dimethyl-, (7.beta.17.beta.)- (9CI)|Androst-4-en-3-one, 17.beta.-hydroxy-7.beta.,17-dimethyl- (8CI)|Androst-4-en-3-one, 7.beta., 17.alpha.-dimethyl-17.beta.-hydroxy-|Dimethyltestosterone|Methosarb|U-22,550	A 17-alkylated orally active androgenic steroid. Calusterone may alter the metabolism of estradiol and reduce estrogen production. (NCI04)
C338	Camptothecin	Topoisomerase-I_Inhibitor	Camptothecin|(+)-Camptothecin|(S)-4-ethyl-4-hydroxy-1H-pyrano-[3',4':6,7]indolozino[1,2-b]quinoline-3,14(4H,12H)-dione|1H-Pyrano[3',3'.6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4-ethyl-4hydroxy-(S)-(9CI)|20(S)-Camptothecine|20-(S)-camptothecine|21, 22-Secocamptothecin-21-oic acid lactone|21, 22-secocamptothecin-21-oic acid lactone|camptothecin|camptothecine	An alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity.  During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI)
C339	Capsaicin	Nonnarcotic_Analgesic	Capsaicin|(E)-N-[(4-Hydroxy-3-methoxyphenyl)methyl]-8-methyl-6-nonenamide|N-(4-hydroxy-3-methoxyphenylmethyl) -8-Methyl-6-Nonenamide|capsaicin	A chili pepper extract with analgesic properties.  Capsaicin is a neuropeptide releasing agent selective for primary sensory peripheral neurons.  Used topically, capsaicin aids in controlling peripheral nerve pain.  This agent has been used experimentally to manipulate substance P and other tachykinins.  In addition, capsaicin may be useful in controlling chemotherapy- and radiotherapy-induced mucositis. (NCI)
C340	Captopril	ACE_Inhibitor	Captopril|(S)-1-(3-Mercapto-2-methyl-1-oxopropyl)-L-proline|CAPTOPRIL|Capoten|captopril	A drug used to lower high blood pressure.  It belongs to the family of drugs called ACE inhibitors.
C341	Carbamazepine	Anticonvulsant_Agent	Carbamazepine|5H-Dibenz(b,f)azepine-5-carboxamide|CARBAMAZEPINE|Epitol|Tegretol
C342	Carboquone	Ethylenimine_Compound	Carboquone
C343	Carbenicillin	Extended_Spectrum_Penicillin_Antibiotic	Carbenicillin|CARBENICILLIN|Geopen|Pyopen	A penicillin antibiotic that inhibits peptidoglycan synthesis involved in bacterial cell, hence inhibiting cell wall biosynthesis causing the bacteria to lyse. (NCI)
C344	Carbohydrate	Organic_Chemical	Carbohydrate|Carbohydrates
C345	Carboxylic_Acids	Organic_Oxoacids	Carboxylic Acids
C346	Carboxypeptidase-G2	Nephroprotective_Agent	Carboxypeptidase-G2|CPDG2|Carboxypeptidase G2|Glucarpidase|Voraxaze|carboxypeptidase-G2	A bacterial enzyme that belongs to the family of drugs called chemoprotective agents. It is used to neutralize the toxic effects of methotrexate.
C347	Carcinogen	Chemical_Modifier	Carcinogen|Cancer Causing Agents|carcinogen	(kar-SIN-o-jin) Any substance that causes cancer.
C348	Environmental_Carcinogen	Carcinogen	Environmental Carcinogen	A substance that can cause cancer in animals and/or humans and is found in the environment either as a contaminant or as a naturally occurring substance. (NCI05)
C349	Carmustine	DNA_Adduct_Forming_Agent|Nitrosourea_Compound	Carmustine|1,3-Bis(2-chloroethyl)-1-nitrosourea|1,3-Bis(beta-chloroethyl)-1-nitrosourea|BCNU|Becenum|Becenun|BiCNU|Bis(chloroethyl) Nitrosourea|Bis-Chloronitrosourea|CARMUSTINE|Carmubris|Carmustin|Carmustine (BCNU)|Carmustinum|FDA 0345|N,N'-Bis(2-chloroethyl)-N-nitrosourea|N,N'-bis(2-chloroethyl)-N-nitrosourea|NSC 409962|Nitrourean|Nitrumon|SK 27702|SRI 1720|WR-139021|carmustine	An anticancer drug that belongs to the family of drugs called alkylating agents.
C350	Carotene	Carotenoid|Hydrocarbon	Carotene	The general name for a group of pigments found in green, yellow, and leafy vegetables, and yellow fruits. The pigments are fat-soluble, unsaturated aliphatic hydrocarbons functioning as provitamins and are converted to vitamin A through enzymatic processes in the intestinal wall.
C351	Carotenoid	Antioxidant|Pigment	Carotenoid|Carotenoids|Carotenoids (NOS)|carotenoids	A class of hydrocarbons (carotenes) and their oxygenated derivatives which exhibit chemopreventive properties.  Carotenoids are pigments found in green, yellow, and leafy vegetables, and yellow fruits. The pigments are fat-soluble, unsaturated aliphatic hydrocarbons functioning as provitamins and are converted to vitamin A through enzymatic processes in the intestinal wall.
C352	Carubicin	Anthracycline_Antibiotic	Carubicin|(2S,3S)-3-acetyl-1,2,3,4,6,11-hexahydro-3,5,10,12-tetrahydroxy-6,11-dioxo-1-naphthacenyl 3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranoside|(8S-cis)-acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetrahydroxy-5,12-naphthacenedione|4-O-demethyldaunorubicin|5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3, 6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9, 10-tetrahydro-1,6,8,11-tetra-hydroxy- (8S-cis)- (8CI 9CI)|5,12-naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-.alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetra-hydroxy-(8S-cis)-(8CI 9CI)|5,12-naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-.alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-1,6,8,11-tetra-hydroxy-,(8S-cis)-(8CI)-(9CI)|CARMINOMYCIN|Carminomycin|Carminomycin I|Demethyldaunomycin|Karminomitsin|Karminomycin|NSC 180024	An anthracycline antineoplastic antibiotic isolated from the bacterium Actinomadura carminata.  Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)
C353	Cefamandole	Cephalosporin_Antibiotic	Cefamandole|(6R,7R)-7-(R)-Mandelamido-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-carboxylic Acid|Cephamandole
C354	Cefotaxime	Cephalosporin_Antibiotic	Cefotaxime|Claforan	A third generation semisynthetic cephalosporin antibiotic that inhibits mucopeptide synthesis by binding to penicillin binding proteins, causing inhibition of bacterial cell wall synthesis.(NCI)
C355	Ceftazidime	Cephalosporin_Antibiotic	Ceftazidime Sodium|CEFTAZIDIME SODIUM|Ceftazidime|Fortaz|Tazicef
C356	Cephalexin	Cephalosporin_Antibiotic	Cephalexin|CEPHALEXIN|Keflex|cephalexin	A first generation semisynthetic cephalosporin antibiotic that inhibits mucopeptide synthesis by binding to penicillin binding proteins, causing inhibition of bacterial cell wall synthesis.(NCI)
C357	Cephalosporin_Antibiotic	Antibiotic	Cephalosporin Antibiotic|Cephalosporins|Suprax|cephalosporins	A class of broad-spectrum antibiotics first isolated from the Mediterranean fungus Acremonium (Cephalosporium acremonium).  Cephalosporins inhibit mucopeptide synthesis by binding to penicillin binding proteins, causing inhibition of bacterial cell wall synthesis. (NCI)
C358	Cephalothin	Cephalosporin_Antibiotic	Cephalothin Sodium|CEPHALOTHIN SODIUM|Cephalothin|Keflin
C359	Ceramide	Intracellular_Second_Messenger	Ceramide|Ceramide (lipids)|N-Acyl Sphingosine|ceramide	A type of fat produced in the body.  It may cause some types of cells to die and is being studied in cancer treatment.
C360	Chelating_Agent	Protective_Agent	Chelating Agent|Chelators
C361	Chewing_Tobacco	Smokeless_Tobacco	Chewing Tobacco|Spit Tobacco	Spit tobacco (smokeless tobacco) comes in two forms: snuff and chew.  Users put a pinch of snuff (called a "dip" or "rub") next to the gum and hold it there.  Chewing tobacco is bulkier than snuff and, as it name suggests, is chewed. (NCI)
C362	Chlorambucil	Nitrogen_Mustard_Compound	Chlorambucil|.gamma.-(p-bis(2-chloroethyl)aminophenyl)butyric acid|.gamma.-[p-Di(2-chloroethyl)aminophenyl]butyric acid|.gamma.-[p-bis(2-chloroethyl)aminophenyl]butyric acid|4-[Bis(2-chloroethyl)amino]benzenebutanoic acid|4-[bis(2-chloroethyl)amino]benzenebutanoic acid|4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid|4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid|Alti-chlorambucil|Ambochlorin|Amboclorin|Aminochlorambucil|Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI)|Butyric acid, 4-(p-[bis(2-chloroethyl)amino]phenyl)-|Butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)-|CB 1348|CB-1348|CHL|CHLORAMBUCIL|Chlorambucilum|Chloraminophen|Chloraminophene|Chlorbutin|Chlorbutine|Chloroambucil|Chlorobutin|Chlorobutine|Ecloril|Elcoril|Leukeran|Leukersan|Leukoran|Linfolizin|Linfolysin|Lympholysin|N,N-Di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid|N,N-di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid|N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid|NSC 3088|Phenylbutyric acid nitrogen mustard|WR-139013|aminochlorambucil|benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI)|butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)|chlorambucil|chlorbutinum|chloroambucil|gamma-(p-bis(2-chloroethyl)aminophenyl)butyric acid|gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid|p-(N, N-Di-2-chloroethyl)aminophenyl butyric acid|p-(N, N-di-2-chloroethyl)aminophenyl butyric acid|p-N, N-Di-(.beta.-chloroethyl)aminophenyl butyric acid|p-N, N-di-(beta-chloroethyl)aminophenyl butyric acid|para-N,N-di(b-chloroethyl)aminophenylbutyric acid|phenylbutyric acid nitrogen mustard	An anticancer drug that belongs to the family of drugs called alkylating agents.
C363	Chloramphenicol	Antibiotic|Protein_Synthesis_Inhibitor	Chloramphenicol|CHLORAMPHENICOL|[R-(R*,R*)]-2,2-Dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide	Chloromycetin; 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-P-nitrophenethyl)-, D-threo-(-)-acetamide. A primarily bacteriostatic antibiotic with wide spectrum of activity against gram-positive and gram-negative cocci and bacilli, first isolated from cultures of Streptomyces venequelae. It binds to the 50S subunit of the ribosome and inhibits bacterial protein synthesis. Reserved for serious infections caused by organisms susceptible to its antimicrobial effects, especially Hemophilus influenza, Streptococcus pneumonia, and neisseria meningitidis. It is used only when less potentially hazardous therapeutic agents are ineffective or contraindicated, because it rarely causes the potentially lethal complication of aplastic anemia. (NCI)
C364	Chlorhexidine	Miscellaneous_Antibiotic	Chlorhexidine|CHLORHEXIDINE
C365	Chlormadinone_Acetate	Therapeutic_Progestin	Chlormadinone Acetate|17-(Acetyloxy)-6-chloropregna-4,6-diene-3,20-dione|Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-chloro-
C366	Chlorophyll	Porphyrin	Chlorophyll
C367	Chlorpromazine	Multidrug_Resistance_Modulator|Phenothiazine	Chlorpromazine|2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine|CHLORPROMAZINE|Chlor-PZ
C368	Cholera_Toxin	Bacterial_Toxin|Enterotoxin	Cholera Toxin	Secreted by Vibrio cholerae, Cholera Toxin is a natural bacterial enterotoxin consisting of major components heavy A- and light B peptides (choleragenoid) that initiates a signaling cascade in intestinal epithelial cells causing a dysfunction of chloride channels, loss of water, and diarrhea. B peptide anchors the protein to epithelia; A peptide enters the cytoplasm and activates adenylate cyclase. Due to its cytotoxicity, cholera toxin is being studied for tumor cell targeting and cancer chemotherapy. (NCI04)
C369	Cholesterol	Steroid_Compound	Cholesterol|(-)-Cholesterol|(3beta)-Cholest-5-en-3-ol|CHOL	Cholesterol is an animal sterol found in the body tissues (and blood plasma) of vertebrates. It can be found in large concentrations within the liver, spinal cord, and brain. Cholesterol is an important component of the membranes of cells, providing stability. It is the major precursor for the synthesis of vitamin D, of the various steroid hormones, including cortisol, cortisone, and aldosterone in the adrenal glands, and of the sex hormones progesterone, estrogen, and testosterone.  Cholesterol also has an important role for the brain synapses as well as in the immune system.  In conditions featuring elevated low density lipoproteins (LDL), cholesterol often forms plaque deposits in the walls of arteries, a condition known as atherosclerosis, which is a major contributor to coronary heart disease and other forms of cardiovascular disease. (from Wikipedia)
C370	Chromium	Metals|Trace_Element	Chromium|Cr	An element with atomic symbol Cr, atomic number 24, and atomic weight 52.
C371	Chromomycin_Antibiotic	Antineoplastic_Antibiotic	Chromomycin Antibiotic|Chromomycins	A class of glycosidic antineoplastic antibiotics isolated from the bacterium Streptomyces griseus.  Chromomycin antibiotics bind to the minor groove of DNA, specifically to guanine/cytosine base pairs, and inhibit RNA synthesis. (NCI04)
C372	Chrysarobin	Mutagen|Quinone_Compound	Chrysarobin|CHRYSAROBIN	An extract of Goa powder; a complex mixture of reduction products of chrysophanic acid, emodin, and emodin monomethyl ether; used locally in ringworm, psoriasis, and eczema.
C373	Chrysenes	Hydrocarbon	Chrysenes	One of the higher aromatic hydrocarbons of coal tar, allied to naphthalene and anthracene. It is a white crystalline substance, C18H12, of strong blue fluorescence, but generally colored yellow by impurities.
C374	Cimetidine	Chemo_Immunostimulant_Adjuvant|Endothelial_Cell_Inhibitor	Cimetidine|N-Cyano-N'-methyl-N''-[2-[[(5-methyl-1H-imidazol-4-yl)methyl]thio]ethyl]guanidine|Tagamet|cimetidine	A drug usually used to treat stomach ulcers and heartburn. It is also commonly used in a regimen to prevent allergic reactions.
C375	Ciprofloxacin	Antitubercular_Agent|Quinolone_Antibiotic|Topoisomerase-II_Inhibitor	Ciprofloxacin|1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid|CIPROFLOXACIN|Cipro|ciprofloxacin	A synthetic broad spectrum fluoroquinolone antibiotic. Ciprofloxacin binds to and inhibits bacterial DNA gyrase, an enzyme essential for DNA replication.  This agent is more active against Gram-negative bacteria than Gram-positive bacteria. (NCI04)
C376	Cisplatin	Platinum_Compound|Radiosensitizing_Agent	Cisplatin|(SP-4-2)-Diamminedichloroplatinum|Abiplatin|Blastolem|Briplatin|CDDP|CISPLATIN|Cis-diammine-dichloroplatinum|Cis-diamminedichloridoplatinum|Cis-diamminedichloro Platinum (II)|Cis-diamminedichloroplatinum|Cis-dichloroammine Platinum (II)|Cis-platinous Diamine Dichloride|Cis-platinum|Cis-platinum II|Cis-platinum II Diamine Dichloride|Cismaplat|Cisplatina|Cisplatinum|Cisplatyl|Citoplatino|Citosin|Cysplatyna|DDP|Lederplatin|Metaplatin|Neoplatin|Peyrone's Chloride|Peyrone's Salt|Placis|Plastistil|Platamine|Platiblastin|Platiblastin-S|Platinex|Platinol|Platinol- AQ|Platinol-AQ|Platinol-AQ VHA Plus|Platinoxan|Platinum|Platinum Diamminodichloride|Platinum, Diaminedichloro-, cis- (8CI)|Platiran|Platistin|Platosin|cisplatin	An anticancer drug that belongs to the family of drugs called platinum compounds.
C377	Clindamycin	Miscellaneous_Antibiotic|Protein_Synthesis_Inhibitor	Clindamycin|7-Chloro-7-deoxylincomycin|Cleocin	A semisynthetic broad spectrum antibiotic produced by chemical modification of the parent compound lincomycin. Clindamycin dissociates peptidyl-tRNA from the bacterial ribosome, thereby disrupting bacterial protein synthesis. (NCI04)
C378	Clofibrate	Anti-lipidemic_Agent	Clofibrate|2-(4-Chlorophenoxy)-2-methylpropanoic acid ethyl ester|Atromid S|Atromid-S|CLOFIBRATE|Ethyl 2-(4-Chlorophenoxy)-2-methylpropanoate|Ethyl p-Chlorophenoxyisobyturate
C379	Clomiphene	Angiogenesis_Activator_Inhibitor|Antiestrogen	Clomiphene|2-[p-(2-Chloro-1,2-diphenylvinyl)phenoxy]triethylamine|Clomid|Clomiphene Citrate|Serophene	A triphenylethylene nonsteroidal ovulatory stimulant evaluated for antineoplastic activity against breast cancer.  Clomiphene has both estrogenic and anti-estrogenic activities that compete with estrogen for binding at estrogen receptor sites in target tissues.  This agent causes the release of the pituitary gonadotropins follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to ovulation. (NCI04)
C380	Clonidine	Adjuvant_Analgesic	Clonidine|CLONIDINE|Catapres-TTS|N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine
C381	Clotrimazole	Antifungal_Agent	Clotrimazole|1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole|CLOTRIMAZOLE|Gyne-Lotrimin|Lotrimin|Mycelex|Mycelex Troches
C382	Cobalt	Trace_Element	Cobalt	An element with atomic symbol Co, atomic number 27, and atomic weight 58.93.
C383	Codeine	Opiate	Codeine Phosphate|CODEINE|CODEINE PHOSPHATE|Codeine|Codeine Sulfate|Codeine, sulfate
C384	Coenzyme_A	Nucleotides	Coenzyme A	A coenzyme containing pantothenic acid, adenosine 3-phosphate 5-pyrophosphate, and cysteamine; involved in the transfer of acyl groups, notably in transacetylations.
C385	Colchicine	Tubulin_Binding_Agent	Colchicine|(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl)acetamide|COLCHICINE	An alkaloid isolated from Colchicum autumnale L. and in other Colchicum species. Colchicine binds to tubulin, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis. (NCI)
C386	Colistin_Sulfate	Miscellaneous_Antibiotic	Colistin Sulfate|Polymixin E	Cyclic polypeptide antibiotic from Bacillus colistinus. It is composed of Polymyxins E1 and E2 (or Colistins A, B, and C) which act as detergents on cell membranes. Colistin is less toxic than Polymyxin B, but otherwise similar; the methanesulfonate is used orally. (Medical Dictionary Online)
C387	Therapeutic_Colony_Stimulating_Factor	Therapeutic_Cytokine|Therapeutic_Hematopoietic_Growth_Factor	Recombinant Colony Stimulating Factor|CSF	Glycoprotein growth factors produced by monocytes, macrophages, or activated lymphocytes that stimulate the proliferation of bone marrow cells and differentiation of stem cells into colonies of granulocytes, monocytes, or macrophages.  These substances act in either paracrine or autocrine fashion on marrow cells, appear to act synergistically in complex and poorly understood ways.  Each appears to exert actions on several lines of progenitor cells and to influence end cell function.  Treatment with colony-stimulating factors (CSF) can help the blood-forming tissue recover from the effects of chemotherapy and radiation therapy.  These factors include interleukin-3 (IL-3), granulocyte colony-stimulating factor (G-CSF), macrophage colony-stimulating factor (M-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF).
C388	Therapeutic_C5a	Therapeutic_Chemokine_Other	Recombinant C5a|C5a
C389	Oral_Contraceptive	Miscellaneous_Hormone_Agent	Oral Contraceptive|Birth Control
C390	Contrast_Agent	Image_Enhancement_Agent	Contrast Agent|Contrast|Contrast Drugs|Contrast Medium	Substances administered during diagnostic procedures that allows delineation of internal structures.  Contrast agents appear opaque due to the difference in absorption of X-rays or other electromagnetic waves and surrounding tissue.
C391	Copper	Metals|Trace_Element	Copper|Cu	An element with atomic symbol Cu, atomic number 29, and atomic weight 63.
C392	Corn_Oil	Food_Oil	Corn Oil|Corn oil
C393	Corticosterone	Glucocorticoid	Corticosterone|(11beta)-11,21-Dihydroxypregn-4-ene-3,20-dione
C394	Therapeutic_Corticotropin_Releasing_Factor	Miscellaneous_Hormone_Agent	Synthetic Human Corticotropin-Releasing Factor|Recombinant Human Corticotropin Releasing Factor|Therapeutic Human Corticotropin Releasing Factor|Xerecept|corticoliberin	A synthetic therapeutic agent which is chemically identical to or similar to the endogenous human corticotropin-releasing factor (hCRF). Synthesized in the hypothalamus, hCRF stimulates the anterior pituitary gland to secrete adrenocorticotropic hormone (ACTH). In cerebral edema, hCRF acts by impeding the flow of fluid from blood vessels into brain tissue, thereby decreasing edema and stabilizing intracranial pressure. This agent possesses anti-edema properties independent of adrenal gland function. (NCI05)
C395	Therapeutic_Cortisone	Therapeutic_Glucocorticoid	Therapeutic Cortisone|17,21-Dihydroxypregn-4-ene-3,11,20-trione|Cortisone|cortisone	A corticosteroid having a potent glucocorticoid and a slight mineralocorticoid activity. (NCI)
C396	Cosmid_Vector	Cloning_Vector	Cosmid Vector	A cloning vector derived from the bacteriophage lambda.  Such a vector includes at least one cos site, the target for DNA uptake into bacteriophage particles and integration into the host genome.  Cosmid vector can hold larger pieces of foreign DNA (inserts) than plasmids.  Cosmids are maintained as circular molecules.  Inserts are generally limited to less than 50 Kb.
C397	Coumarin	Anticoagulant_Agent	Coumarin|2H-1-Benzopyran-2-one|COUMARIN|Tonka Bean Camphor|Tonka bean camphor	O hydroxycinnamic acid. Pleasant smelling compound found in many plants and released on wilting (probably a major component of the smell of fresh hay). Has anticoagulant activity by competing with Vitamin K. (On-line Medical Dictionary)
C398	Diltiazem_Hydrochloride	Calcium_Channel_Blocker	Diltiazem Hydrochloride|Cardizem|DILTIAZEM HYDROCHLORIDE|Diltiazem HCl	A benzothiazepine calcium channel blocking agent. Diltiazem hydrochloride inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility.  Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells. (NCI04)
C399	Creatinine	Heterocyclic_Compound	Creatinine|CREA|CREATININE|creatinine	(cree-AT-ih-nin) A compound that is excreted from the body in urine.  Creatinine levels are measured to monitor kidney function.
C400	Crotoxin	Neurotoxin|Vaccine_Adjuvant	Crotoxin
C401	Curcumin	Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor|Pigment|Protein_Kinase_C_Inhibitor	Curcumin|(E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione|C.I. 75300|C.I. Natural Yellow 3|CURCUMIN|Diferuloylmethane|Turmeric Yellow|curcumin	A phytopolylphenol pigment isolated from the plant Curcuma longa, commonly known as tumeric, with a variety of pharmacologic properties.  Curcumin blocks the formation of reactive-oxygen species, possesses anti-inflammatory properties as a result of inhibition of cyclooxygenases (COX) and other enzymes involved in inflammation; and disrupts cell signal transduction by various mechanisms including inhibition of protein kinase C.  These effects may play a role in the agent's observed antineoplastic properties, which include inhibition of tumor cell proliferation and suppression of chemically induced carcinogenesis and tumor growth in animal models of cancer. (NCI04)
C402	Cyanogen_Bromide	Inorganic_Chemical	Cyanogen Bromide|Cyanogen bromide	An inorganic compound used as a reagent in molecular biology.  As a reagent for peptide mapping and amino acid sequence analysis, cyanogen bromide hydrolyzes peptide bonds at methionine residues in peptides and proteins.  In addition, this agent acts as a coupling reagent for phosphoramidate or pyrophosphate inter-nucleotide bonds in DNA duplexes. (NCI)
C403	Ancitabine_Hydrochloride	Pyrimidine_Antagonist	Ancitabine Hydrochloride|6H-furo(2',3':4,5)oxazolo(3,2-a)pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-3-hydroxy-6-imino-,(2R(2alpha,3beta,3a beta,9a beta))|Ancid|Ancitabine|Ancitabine hydrochloride|Ancytabine Hydrochloride|CycloCMP Hydrochloride|CycloCMP hydrochloride|Cyclocytidine|Cyclocytidine HCL|Cyclocytidine Hydrochloride|Cyclocytidine hydrochloride|NSC-145668|U-33, 624A	A derivative of cytarbine (ara-C).  Although ancitabine's mechanism of action is unclear, it may inhibit DNA polymerase via competitive inhibition of deoxycytidine triphosphatase, resulting in inhibition of DNA replication; this agent may also incorporate into DNA and RNA. (NCI04)
C404	Cycloleucine	Immunosuppressant	Cycloleucine|1-Aminocyclopentane|1-Aminocyclopentanecarboxylic acid|1-aminocyclopentanecarboxylic acid|ACPC|CB 1639|CB-1639|NSC 1026	A synthetic amino acid derivative of cyclopentanecarboxylic acid, Cycloleucine displays immunosuppressive, antineoplastic, and cytostatic properties. Believed to act in vivo as a valine antagonist and an NMDA receptor antagonist acting at the glycine site, Cycloleucine is a competitive inhibitor of many enzymes, such as methionine adenosyltransferase (S-adenosylmethionine biosynthesis). Toxicity is correlated with a block of nucleic acid methylation; cell cycle progression; and DNA, RNA and protein biosynthesis. (NCI04)
C405	Cyclophosphamide	Immunosuppressant|Nitrogen_Mustard_Compound	Cyclophosphamide|(-)-Cyclophosphamide|1-bis(2-chloroethyl)-amino-1-oxo-2-aza-5-oxaphosphoridin monohydrate|2-[bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate|2-[bis(b-chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane-2-oxide monohydrate|2-[di(chloroethyl)amino]-1-oxa-3-aza-2-phosphacyclohexane 2-oxide monohydrate|2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate|2H-1,3,2-oxazaphosphorin-2-amine, N,N-is(2-chloroethyl)tetrahydro-,2-oxide|Asta B 518|B 518|B-518|Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester monohydrate|CP monohydrate|CTX|CYCLO-cell|Carloxan|Ciclofosfamida|Ciclofosfamide|Cicloxal|Clafen|Claphene|Cycloblastin|Cycloblastine|Cyclophospham|Cyclophosphamid monohydrate|Cyclophosphamidum|Cyclophosphan|Cyclophosphane|Cyclophosphanum|Cyclostin|Cyclostine|Cytophosphan|Cytophosphane|Cytoxan|Endoxan|Endoxana|Enduxan|Fosfaseron|Genoxal|Genuxal|Ledoxina|Mitoxan|N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-Oxide|N,N-bis(2-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate|N,N-bis(2-chloroethyl)-N'-(3-hydroxypropyl)phosphorodiamidic acid intramolecular ester monohydrate|N,N-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide monohydrate|N,N-bis(b-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate|N,N-bis(beta-chloroethyl)-N',O-propylenephosphoric acid ester diamide monohydrate|N,N-bis(beta-chloroethyl)-N',O-trimethylenephosphoric acid ester diamide monohydrate|NSC 26271|Neosar|Procytox|Sendoxan|Syklofosfamid|WR- 138719|Zytoxan|bis(2-chloroethyl)phosphamide cyclic propanolamide ester monohydrate|cyclophosphamide	A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.  In the liver, cyclophosphamide is converted to the active metabolites aldophosphamide and phosphoramide mustard, which bind to DNA, thereby inhibiting DNA replication and initiating cell death. (NCI04)
C406	Cyclosporine	Immunosuppressant|Multidrug_Resistance_Modulator	Cyclosporine|27-400|Ciclosporin|CsA|Cyclosporin|Cyclosporin A|Neoral|OL 27-400|Sandimmun|Sandimmune|SangCya|cyclosporine	A drug used to help reduce the risk of rejection of organ and bone marrow transplants by the body. It is also used in clinical trials to make cancer cells more sensitive to anticancer drugs.
C407	Cyproterone	Anti-Androgen	Cyproterone|Med Cyproterone|SH-881	A synthetic steroidal anti-androgen with antineoplastic activity. Cyproterone, in its acetate form, binds the androgen receptor (AR), thereby preventing androgen-induced receptor activation and inhibiting the growth of testosterone-sensitive tumor cells.  This agent also exerts progesterogenic activity, resulting in a reduction in testicular androgen secretion and total androgen blockade. (NCI04)
C408	Cytosine_Arabinoside	Pyrimidine_Antagonist	Cytosine Arabinoside|.beta.-Cytosine arabinoside|1-.beta.-D-Arabinofuranosyl-4-amino-2(1H)pyrimidinone|1-.beta.-D-Arabinofuranosylcytosine|1-Beta-D-arabinofuranosylcytosine|1.beta.-D-Arabinofuranosylcytosine|2(1H)-Pyrimidinone, 4-amino-1.beta.-D-arabinofuranosyl-|4-Amino-1-beta-D-arabinofuranosyl-2(1H)-pyrimidinone|ARA-cell|Alexan|Ara-C|Arabine|Arabinofuranosylcytosine|Arabinosylcytosine|Aracytidine|Aracytin|Aracytine|Beta-Cytosine Arabinoside|CHX-3311|CYTARABINE|Cytarabine|Cytarabine Hydrochloride|Cytarabinum|Cytarbel|Cytosar|Cytosar-U|Cytosine Arabinosine Hydrochloride|Cytosine-.beta.-arabinoside|Erpalfa|Starasid|Tarabine PFS|U 19920|U-19920|U-29920A HCl|Udicil|WR-28453|cytarabine	An anticancer drug that belongs to the family of drugs called antimetabolites.
C409	Cytidine	Nucleoside	Cytidine
C410	Cytosine	Pyrimidine	Cytosine|4-Amino-2(1H)-pyrimidinone|CYTOSINE
C411	Dacarbazine	Triazene_Compound	Dacarbazine|1H-imidazole-4-carboxamide, 5-(3,3-dimethyl-1-triazenyl)-|4-(Dimethyltriazeno)imidazole-5-carboxamide|5(or 4)-(dimethyltriazeno)imidazole-4(or 5)-carboxamide|5-(3-3-dimethyl-1-triazenyl)-1H-imidazole-4-carboxamide|5-(Dimethyltriazeno)imidazole-4-carboxamide|5-(dimethyltriazeno)imidazole-4-carboxamide|Asercit|Biocarbazine|DIC|DTIC|DTIC-Dome|Dacarbazina|Dacarbazina Almirall|Dacarbazine (DTIC)|Dacarbazine - DTIC|Dacatic|Dakarbazin|Deticene|Detimedac|Dimethyl (triazeno) imidazolecarboxamide|Dimethyl Triazeno Imidazol Carboxamide|Dimethyl Triazeno Imidazole Carboxamide|Dimethyl-triazeno-imidazole-carboximide|Fauldetic|Imidazole Carboxamide|Imidazole Carboxamide Dimethyltriazeno|Imidazole carboxamide|NSC 45388|WR-139007|dacarbazine|dimethyl-triazeno-imidazole carboxamide	A triazene derivative with antineoplastic activity. Dacarbazine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)
C412	Dactinomycin	Actinomycin_Antibiotic	Dactinomycin|2-bis[Cyclo(N-methyl-L-valyl-sarcosyl-L-prolyl-D-valyl-L-threonyl)]-1,9 dimethyl-4,6 3H-phenoxazinone-3|ACTINOMYCIN D|Actinomycin A IV|Actinomycin C1|Actinomycin D|Actinomycin I1|Actinomycin IV|Actinomycin X 1|Actinomycin-[thr-val-pro-sar-meval]|Cosmegen|DACT|DACTINOMYCIN|Dactinomycine|Lyovac Cosmegen|Lyovac cosmegen|Meractinomycin|NSC-3053|dactinomycin	A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces parvulus.  Dactinomycin intercalates between adjacent guanine-cytosine base pairs, blocking the transcription of DNA by RNA polymerase; it also causes single-strand DNA breaks, possibly via a free-radical intermediate or an interaction with topoisomerase II. (NCI04)
C413	Dairy_Product	Food_and_Food_Product	Dairy Product
C414	Danazol	Anabolic_Steroid|Gonadotropin_Releasing_Hormone_Inhibitor|Therapeutic_Androgen	Danazol|(17Alpha)-pregna-2,4-dien-20-yno[2,3-d]-isoxazol-17-ol|(17alpha)-Pregna-2,4-dien-20-yno[2,3-d]isoxazol-17-ol|1-Ethynyl-2,3,3a,3b,4,5,10,10a,10b,11,12,12a-dodecahydro-10a,12a-dimethyl-1H-cyclopental[7,8]phenanthro[3,2-d]isoxazol-1-ol|17Alpha-ethynyl-17beta-hydroxy-4-androsteno[2,3-d]isoxazole|Bonzol|Chronogyn|Cyclomen|DANAZOL|Danocrine|Danol|Danoval|Ladogal|Win 17757|Win-17757|Winobanin|danazol	A synthetic androgen derived from ethinyl testosterone.  Danazol indirectly reduces estrogen production by decreasing pituitary secretion of follicle-stimulating hormone and luteinizing hormone, and binds to sex hormone receptors in target tissues, thereby exhibiting antiestrogenic, anabolic and weakly androgenic effects. (NCI04)
C415	Dapsone	Sulfone_Anti-Infective_Agent	Dapsone|1358F|4,4'-Sulfonylbis[benzenamine]|4,4'-Sulfonylbisbenzamine|4,4'-Sulfonylbisbenzeneamine|4,4'-Sulfonyldianiline|Avlosulfon|Bis(4-aminophenyl) sulfone|Bis(4-aminophenyl)sulfone|Croysulfone|DADPS|DAPSONE|DDS|Diphenasone|Disulone|Dumitone|Eporal|Novophone|Sulfona-MAE|Sulfona-Mae|Sulphadione|Undolac	A synthetic derivative of diamino-sulfone with anti-mycobacterial and anti-malarial properties.  A structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. (NCI04)
C416	Deferoxamine	Chelating_Agent	Deferoxamine|1-Amino-6,17-dihydroxy-7,10,18,21-tetraoxo-27-(n-acetylhydroxylamino)-6,11,17,22-tetraazaheptaeicosane|Desferrioxamine|N'-[5-[[4-[[5-(Acetylhydroxyamino)pentyl]amino]-1,4-dioxobutyl]hydroxyamino]pentyl]-N-(5-aminopentyl)-N-hydroxybutanediamide|N-[5-[3-[5-Aminopentyl)hydroxycarbamoyl]propionamido]pentyl]-3-[[5-(N-hydroxyacetamido)pentyl]carbamoyl]propionohydroxamic Acid|deferoxamine	An iron-chelating agent that binds free iron in a stable complex, preventing it from engaging in chemical reactions. Deferoxamine chelates iron from intra-lysosomal ferritin and siderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile.  This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. (NCI04)
C417	Deferoxamine_Mesylate	Deferoxamine	Deferoxamine Mesylate|DEFEROXAMINE MESYLATE|DFM|Deferoxamine B|Deferoxamine Methanesulfonate|Deferoxamine mesylate|Deferrioxamine B|Desferal|Desferrioxamine Mesylate	An iron chelating agent.  Deferoxamine mesylate chelates free iron, and the iron of ferritin and hemosiderin within lysosomes, thereby forming ferrioxamine, a water-soluble chelate that is excreted by the kidneys and in the bile.  This agent does not bind iron readily from transferrin, hemoglobin, myoglobin or cytochromes. (NCI04)
C418	Dehydroemetine	Antiprotozoal_Agent	Dehydroemetine	A synthetic derivative of emetine; used in the treatment of intestinal amoebiasis. (On-line Medical Dictionary)
C419	Demecolcine	Tubulin_Binding_Agent	Demecolcine|DEMECOLCINE
C420	Deoxycytidine	Miscellaneous_Chemoprotective_Agent|Pyrimidine_Antagonist	Deoxycytidine|deoxycytidine	A drug that protects healthy tissues from the toxic effects of anticancer drugs.
C421	Deoxyguanosine	Nucleoside	Deoxyguanosine
C422	Dexamethasone	Antiemetic_Agent|Therapeutic_Glucocorticoid	Dexamethasone|(11Beta,16alpha)-9-fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione|1-Dehydro-16alpha-methyl-9alpha-fluorohydrocortisone|16Alpha-methyl-9alpha-fluoro-1,4-pregnadiene-11beta,17alpha,21-triol-3,20-dione|16Alpha-methyl-9alpha-fluoro-delta1-hydrocortisone|16Alpha-methyl-9alpha-fluoroprednisolone|9Alpha-fluoro-11beta,17alpha,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione|9Alpha-fluoro-16alpha-methylprednisolone|9alpha-Fluoro-16alpha- methylprednisolone|Aacidexam|Adexone|Aknichthol Dexa|Alba-Dex|Alin|Alin Depot|Alin Oftalmico|Ambene|Amplidermis|Anemul mono|Antimicotico|Aquapred|Auricularum|Auxiloson|Azona|Baycuten|Baycuten N|Corson|Cortidexason|Cortisumman|DEXAMETHASONE|Decacort|Decadrol|Decadron|Decalix|Decameth|Decasone R.p.|Dectancyl|Deenar|Dekacort|Deltafluorene|Deronil|Desamethasone|Desameton|Dex-4|Dexa-Mamallet|Dexa-Rhinosan|Dexa-Scheroson|Dexa-sine|Dexace|Dexacortal|Dexacortin|Dexafarma|Dexafluorene|Dexalocal|Dexamecortin|Dexameth|Dexamethasonum|Dexamonozon|Dexapos|Dexinoral|Dexone|Dinormon|Fluoro-9alpha Methyl-16alpha Prednisolone|Fluorodelta|Fortecortin|Gammacorten|Hexadecadrol|Hexadrol|Lokalison-F|Loverine|Methylfluorprednisolone|Millicorten|Mymethasone|Ocasa|Orgadrone|Predni-F|Spersadex|Visumetazone|dexamethasone	A synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (NCI04)
C423	Dextromethorphan	Adjuvant_Analgesic	Dextromethorphan Hydrobromide|DEXTROMETHORPHAN HYDROBROMIDE|DXM|Dextromethorphan
C424	Heroin	Substance_of_Abuse	Heroin
C425	Dianhydrogalactitol	Epoxide_Compound	Dianhydrogalactitol|1,2,5,6 dianhydrogalactitol|1,2:5, 6-Dianhydrogalactitol|1,2:5, 6-diepoxydulcitol|1,2:5,6 dianhydrogalactitol|1,2:5,6-Dianhydrodulcitol|1,2:5,6-Diepoxydulcitol|1,2:5,6-dianhydrodulcitol|DAG|Dianhydrodulcitol|Dulcitol diepoxide|Galactitol|Galactitol, 1,2:5,6-dianhydro- (8CI 9CI)|NSC 132313|dianhydrodulcitol|diepoxydulcitol|diepoxygalactitol|dulcitol diepoxide|galactitol, 1,2:5,6-dianhydro- (8CI 9CI)	A bifunctional hexitol derivative with potential antineoplastic activity. Dianhydrogalactitol alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in disruption of DNA function and cell cycle arrest. (NCI04)
C426	Diazonium_Compounds	Nitrogen_Compound	Diazonium Compounds	The salt form of diazo compounds, compounds containing the N2 nitrogen attached to only one hydrocarbon, formulated by replacing three hydrogen atoms of the salt of an aryl primary amine by nitrogen having the general structure represented as R-N2X.(NCI)
C427	Diazooxonorleucine	Cytidine_Triphosphate_Synthetase_Inhibitor|Miscellaneous_Antineoplastic_Antibiotic|Purine_Antagonist	Diazooxonorleucine|6-DIAZO-5-OXO-L-NORLEUCINE|6-diazo-5-oxo-L-norleucine|6-diazo-5-oxo-norleucine|DON|NSC-7365	An antibiotic with potential antineoplastic activity. As an L-glutamine antagonist, diazooxonorleucine inhibits phosphate-activated glutaminase, thereby interfering with glutamine metabolism, ultimately depleting cells of this essential amino acid.
C428	Diazoxide	Vasodilating_Agent	Diazoxide|3-Methyl-7-chloro-1,2,4-benzothiadiazine 1,1-Dioxide|SRG-95213
C429	Dideoxyadenosine	Anti-HIV_Agent|Reverse_Transcriptase_Inhibitor	Dideoxyadenosine|2',3'-Dideoxyadenosine|6-Amino-9-(2''3'-dideoxy-beta-D-glycero-pentofuranosyl)purine|ddA	A synthetic nucleoside analogue of deoxyadenosine and a prodrug of didanosine in which the 3' hydroxyl group on the ribose moiety is replaced by a hydrogen atom. Dideoxyadenosine competitively inhibits adenylyl cyclase, thereby reducing levels of cyclic adenosine monophosphate (cAMP). By inhibiting cAMP-mediated gene activation in tumor cells, this agent may retard tumor cell proliferation. (NCI04)
C430	Zalcitabine	Reverse_Transcriptase_Inhibitor	Zalcitabine|2',3'-Dideoxycytidine|Dideoxycytidine|Hivid|ZALCITABINE|ddC|ddc	A synthetic dideoxynucleoside. After intracellular phosphorylation to its active metabolite, zalcitabine preferentially inhibits the gamma form of DNA polymerase present in tumor cell mitochondria, resulting in the inhibition of tumor cell mitochondrial DNA replication and tumor cell death. (NCI04)
C431	Didanosine	Anti-HIV_Agent|Reverse_Transcriptase_Inhibitor	Didanosine|2',3'-Dideoxyinosine|DIDANOSINE|Didanosine EC|Dideoxyinosine|Dideoxyinosine (didanosine- Videx)|Videx|Videx EC|ddI|didanosine	A drug used to treat infection caused by viruses.
C432	Diethyldithiocarbamate	Chelating_Agent|Immunostimulant	Diethyldithiocarbamate|DDTC|DIECA|Diethylcarbamodithioic Acid|Diethyldione|Diethyldithiocarbamic Acid|Diethyldithiocarbaminic Acid|Diethyldithione|Imuthiol	A sulfhydryl-containing carbamate that is the primary in vivo metabolite of disulfiram. Diethyldithiocarbamate chelates zinc, thereby inhibiting metalloproteinases, thereby preventing the degradation of the extracellular matrix and inhibiting an initial step in cancer metastasis and angiogenesis. A known inhibitor of superoxide dismutase, this agent can either potentiate or protect against cell oxidative damage caused by ionizing radiation, depending on the time of administration. (NCI04)
C433	Diethylstilbestrol	Non-Steroidal_Estrogen	Diethylstilbestrol|(E)-4,4'-(1,2-diethyl-1,2-ethenediyl)bisphenol|.alpha., .alpha.'-Diethylstilbenediol|3, 4-Bis(p-hydroxyphenyl)-3-hexene|3,4-Bis(p-hydroxyphenyl)-3-hexene|3-Hexene,3,4-bis(p-hydroxyphenyl)-|4,4'-Dihydroxy-.alpha., .beta.-diethylstilbene|4,4'-Dihydroxy-alpha,beta-diethylstilbene|Acnestrol|Alpha,alpha'-diethylstilbenediol|Antigestil|Apstil|Boestrol|Bufon|Cyren A|DES|Deladumone|Diastyl|Diethylstilbenediol|Diethylstilbestrol Dipropionate|Diethylstilbestrolum|Diethylstilboestrol|Distilbene|Domestrol|Estrobene|Estrosyn|Fonatol|Grafestrol|Makarol|Microest|Milestrol|Neo-Oestronol I|Oestrogenine|Oestromenin|Oestromensyl|Oestromon|Palestrol|Serral|Sexocretin|Sibol|Sinestrol|Stilbestrol|Stilbetin|Stilboefral|Stilboestroform|Stilboestrol|Stilboestrol Dipropionate|Stilkap|Synestrin|Synthoestrin|Trans-bis-(hydroxy-4-phenyl)-3,4 hexene-3|Vagestrol|diethylstilbestrol	(dye-ETH-ul-stil-BES-trol) DES. A synthetic hormone that was prescribed from the early 1940s until 1971 to help women with complications of pregnancy. DES has been linked to an increased risk of clear cell carcinoma of the vagina in daughters of women who used DES. DES may also increase the risk of breast cancer in women who used DES.
C434	Digestant	Miscellaneous_Adjuvant	Digestant	1. Aiding digestion. 2. An agent that favors or assists the process of digestion.
C435	Diacylglycerol	Intracellular_Second_Messenger	Diacylglycerol
C436	Hydromorphone	Opioid	Hydromorphone Hydrochloride|(-)-Hydromorphone|Dihydromorphinone|Dilaudid|Dilaudid HP|Dimorphone|HYDROMORPHONE HYDROCHLORIDE|Hydromorphon|Hydromorphone|Hydrostat|Hymorphan|Laudicon|Novolauden|hydromorphone	A drug used to relieve pain.
C437	Dimethyl_Sulfoxide	Miscellaneous_Chemoprotective_Agent	Dimethyl Sulfoxide|(DMSO)|DIMETHYL SULFOXIDE|DMSO|Demasorb|Demeso|Domoso|Dromisol|SQ 9453|SQ-9453|Sulfinylbismethane|dimethyl sulfoxide	A colorless liquid that readily dissolves many chemicals and penetrates animal and plant tissues.  It is used in human medicine, veterinary medicine, and pharmaceuticals.
C438	Dimethylhydrazines	Nitrogen_Compound	Dimethylhydrazines
C439	Dinitrochlorobenzene	Diagnostic_Reagent|Immunostimulant	Dinitrochlorobenzene|1,3-Dinitro-4-chlorobenzene|1,3-dinitro-4-chlorobenzene|1-Chloro-2,4-dinitrobenzol|2,4-Dinitro-1-chlorobenzene|2,4-Dinitrochlorobenzene|2,4-dinitro-1-chlorobenzene|2,4-dinitrochlorobenzene|2-4 Dinitrochlorobenzene|DNCB
C440	Dinitrofluorobenzene	Aromatic_Compounds	Dinitrofluorobenzene|1-Fluoro-2,4-dinitrobenzene|1-fluoro-2,4-dinitrobenzene|2,4-dinitrobenzene fluoride|2,4-nitrofluorobenzene|DNFB|Sanger's Reagent
C441	Dinitrophenyl_Compounds	Aromatic_Compounds	Dinitrophenyl Compounds	Nitroaromatic compounds containing two nitrogen groups on a phenyl ring used as pharmaceuticals, pesticides, explosives, and comprise a group of environmental pollutants.(NCI)
C442	Dioxin_Compound	Organochlorine_Compound	Dioxin Compound|Dioxin|Dioxins	Any of several toxic or carcinogenic hydrocarbons that occur as impurities in herbicides.
C443	Biphosphonate	Adjuvant_Analgesic|Malignancy-Associated_Hypercalcemia_Inhibitor	Biphosphonate|Diphosphonate|Diphosphonates|bisphosphonates|diphosphonates	A family of drugs used to treat osteoporosis and the bone pain caused by some types of cancer. Also called diphosphonates.
C444	Diphtheria_Toxin	Bacterial_Toxin|Protein_Synthesis_Inhibitor	Diphtheria Toxin
C445	Dipyridamole	Multidrug_Resistance_Modulator|Radioprotective_Agent|Radiosensitizing_Agent	Dipyridamole|2,2',2'',2''''-[(4,8-Dipiperidinopyrimido-[5,4-d]pyrimidine-2,6-diyl)dinitrilo]tetraethanol|DIPYRIDAMOLE|Persantine|dipyridamole	A drug that prevents blood cell clumping and enhances the effectiveness of fluorouracil and other chemotherapeutic agents.
C446	Distamycin_Antibiotic	Antineoplastic_Antibiotic	Distamycin Antibiotic|Distamycins	A class of oligopeptide antineoplastic antibiotics isolated from the bacterium Streptomyces distallicus.  Distamycin antibiotics bind to the minor groove of DNA, preferentially to adenine-thymine (A-T) rich sequences, thereby inhibiting DNA replication and RNA transcription.  In addition to their antitumor effects, these agents possess antiviral and antiprotozoal activities. (NCI04)
C447	Disulfiram	Multidrug_Resistance_Modulator	Disulfiram|Antabuse|Bis(diethylthiocarbamoyl) Disulfide|DISULFIRAM|TTD|Tetraethylthioperoxydicarbonic Diamide|Tetraethylthiuram Disulfide|Teturamin|disulfiram	A drug that slows the metabolism of retinoids, allowing them to act over a longer period of time.
C448	Diuretic	Adjuvant	Diuretic|diuretic	A drug that increases the production of urine.
C449	Deoxyribonucleic_Acid	Nucleic_Acids	Deoxyribonucleic Acid|DNA|Deoxyribonucleic acid|deoxyribonucleic acid	The molecules inside cells that carry genetic information and pass it from one generation to the next.
C450	DNA_Insertion_Elements	Deoxyribonucleic_Acid	DNA Insertion Elements|Transposable Element
C451	DNA_Probes	Deoxyribonucleic_Acid	DNA Probes	A piece of DNA that has been labeled, usually radioactively or with a fluorescent dye, which is used in hybridization studies.  Applications include Northern and Southern blots, in situ hybridization techniques, and diagnostic tests.  DNA probes can be highly specific or degenerate.
C452	HPV_DNA_Probes	DNA_Probes	HPV DNA Probes
C453	Recombinant_DNA	Deoxyribonucleic_Acid	Recombinant DNA|Molecular Biology, Recombinant DNA	DNA artificially constructed by combining genes from different organisms or by cloning chemically altered DNA, usually for the purpose of genetic manipulation.
C454	Domperidone	Antiemetic_Agent	Domperidone|KW 5338|Motilium|R 33,812
C455	Dopamine	Neurotransmitter	Dopamine Hydrochloride|DOPAMINE HYDROCHLORIDE|Dopamine
C456	Doxorubicin	Anthracycline_Antibiotic	Doxorubicin|(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroacetyl)-1-methoxy-5,12-naphthacenedione|(8S-cis)-10-[(3-Amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione|14-Hydroxydaunomycin|Doxorubicina|Hydroxyl Daunorubicin|Hydroxyldaunorubicin|doxorubicin	An anthracycline antineoplastic antibiotic isolated from the fungus Streptococcus peucetius var. caesius.  Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.  The hydrochloride salt doxorubicin hydrochloride is the therapeutic form of doxorubicin. (NCI04)
C457	Doxycycline	Tetracycline_Antibiotic	Doxycycline|DOXYCYCLINE|Doxycycline Monohydrate|Vibramycin|doxycycline	A synthetic tetracycline derivative exhibiting antimicrobial activity.  Doxycycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis.  In addition, this agent has exhibited inhibition of collagenase activity. (NCI)
C458	Droperidol	Butyrophenone	Droperidol|DROPERIDOL|Inapsine
C459	Medication	Conceptual_Entities	Medication|MEDS	A drug or substance that treats or prevents or alleviates the symptoms of disease.
C460	Pentetic_Acid	Chelating_Agent	Pentetic Acid|(Diethylenetriamine)pentaacetic acid|DTPA|Detapac|Detarex|Diethylenetriamine Pentaacetic Acid	A chelating agent that forms complexes with the metallic radioisotopic moieties of unbound, extracellular radioimmunotherapeutic agents, resulting in higher specific tumor cell binding of radioimmunotherpeutic agents, and so improved tumor cell radiocytotoxicity, while sparing normal cells and tissues from the radiocytotoxic effects of these agents. (NCI)
C461	Dye	Industrial_Product	Dye
C462	Echinomycin	DNA_Minor_Groove_Binding_Agent|Intercalating_Agent|Miscellaneous_Antineoplastic_Antibiotic	Echinomycin|BRN 0078671|Bis-Quinoline Analogue|Echinomycin A|Levomycin|N,N'-(2,4,12,15,17,25-hexamethyl-11,24-bis(1-methylethyl)-27-(methylthio)-3,6,10,13,16,19,23,26-octaoxo-9,22-dioxa-28-thia-2,5,12,15,18,25-hexaazabicyclo(12.12.3)nonacosane-7,20-diyl)bis(2-quinoxalinecarboxamide)|Quinomycin A|SK 302B	A polypeptide quinoxaline antineoplastic antibiotic isolated from the bacterium Streptomyces echinatus.  Echinomycin intercalates into DNA at two locations simultaneously in a sequence-specific fashion, thereby inhibiting DNA replication and RNA synthesis. (NCI04)
C463	Eicosanoid	Physiology-Regulatory_Factor	Eicosanoid
C464	Electrolytes	Inorganic_Chemical	Electrolytes|ELECT|electrolytes	Substances that ionize into anions and cations in body fluids.  Electrolytes regulate nerve and muscle function and water distribution between cells, plasma, and interstitial fluid.  Imbalances can cause serious physiologic effects, including seizures, cardiac arrhythmias and convulsions.(NCI)
C465	Radioactive_Element	Element_or_Isotope	Radioactive Element|Elements, radioactive
C466	Emodin	Tyrosine_Kinase_Inhibitor	Emodin|1,3,8-Trihydroxy-6-methylanthraquinone|3-Methyl-1,6,8-trihydroxy-antraquinone|EMODIN
C467	Emollient	Retired_Concepts	Emollient
C468	Enalapril	ACE_Inhibitor	Enalapril Maleate|ENALAPRIL MALEATE|Enacard|Enalapril|Renitec|Vasotec|enalapril	A dicarbocyl-containing peptide with antihypertensive activity.  As a prodrug, enalapril is converted by deesterification into its active form enalaprilat.  Enalaprilat inhibits angiotensin converting enzyme, thereby blocking the conversion of angiotensin I to angiotensin II, decreasing aldosterone secretion, increasing bradykinin levels and ultimately causing vasodilation. (NCI)
C469	Endorphin	Neurotransmitter	Endorphin|Endogenous Opiates
C470	Enterotoxin	Toxin	Enterotoxin
C471	Enzyme_Inhibitor	Pharmacologic_Substance	Enzyme Inhibitor|Enzyme Antagonist|Enzyme Inhibitor Agent|Enzyme Inhibitor Drug
C472	Ephedrine	Miscellaneous_Chemoprotective_Agent	Ephedrine|(-)-Ephedrine|EPHEDRINE|[R-(R*,S*)]-alpha-[1-(Methylamino)ethyl]benzenemethanol
C473	Therapeutic_Epinephrine	Adrenal_Agent	Therapeutic Epinephrine|Adrenaline|EPINEPHRINE|Epi|Epinephrine|adrenaline|epinephrine	A sympathomimetic agent interacting with both alpha- and beta-adrenergic receptors, causing cardiac stimulation, vasoconstriction, bronchodilation, blood glucose elevation, and gastrointestinal relaxation.  Clinical Use: Ventricular Fibrillation, Anaphylactic Shock, Asthma, Cardiopulmonary Resuscitation, Glaucoma, and Topical Anesthetic-Adjuvant.(NCI)
C474	Epirubicin	Anthracycline_Antibiotic	Epirubicin Hydrochloride|(8S-cis)-10-((3-Amino-2,3,6-trideoxy-beta-L-arabino-hexopyranosyl)oxy-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione|(8S-cis)-10-[(-Amino-2,3,6-trideoxy-alpha-L-arabino-hexpyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxacetyl)-1-methoxy-5,12-naphthacenedione|3-Glycoloyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-arabino-hexopyranoside|4'-Epiadriamycin|4'-Epidoxorubicin|4'-epi DX|EPIRUBICIN HYDROCHLORIDE|Ellence|Epi DX|Epidoxorubicin|Epirubicin|IMI-28|Pharmorubicin PFS|Pidorubicin|epirubicin	An anticancer drug that belongs to the family of drugs called antitumor antibiotics.
C475	Epoxide_Compound	Antineoplastic_Alkylating_Agent	Epoxide Compound	3-membered organic ring structure containing oxygen.
C476	Erythromycin	Macrolide_Antibiotic	Erythromycin|E-Mycin|ERYC|ERYTHROMYCIN|Ery-Tab|EryDerm|Eryc|Eryderm|Erythro|Erythrocin|Ilotycin|RP-Mycin|Robimycin
C477	Recombinant_Erythropoietin	Miscellaneous_Chemoprotective_Agent|Therapeutic_Hematopoietic_Growth_Factor	Recombinant Erythropoietin|Erythrocyte Colony Stimulating Factor|Erythropoietin|Hematopoietin|Recombinant EPO	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein erythropoietin (Epo).  Epo promotes the differentiation and maturation of hematopoietic progenitors into erythrocytes; is a mitogen and a chemoattractant for endothelial cells; stimulates activated and differentiated B-cells and enhances B-cell immunoglobulin production and proliferation; and is hypoxia-inducible. (NCI04)
C478	Therapeutic_Estradiol	Steroidal_Estrogen	Therapeutic Estradiol|17 Beta-Estradiol|Aquadiol|Dimenformon|Diogyn|Diogynets|ESTRADIOL|Estrace|Estraldine|Oestradiol|Ovocylin|Progynon	A steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.  Typically esterified, estradiol derivatives are formulated for oral or parenteral administration.  As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors.  Estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability.
C479	Estramustine	Nitrogen_Mustard_Compound|Steroidal_Estrogen|Tubulin_Binding_Agent	Estramustine|17beta-(estra-1,3,5(10)-triene-3,17-diol 3-[bis(2-chloroethyl)carbamate]|Estradiol 3-[bis(2-chloroethyl)carbamate]|Ro 22-2296/000|estra-1,3,5(10)triene-317beta-diol 3-[N,N-bis-(2-chloroethyl)carbamate]|estradiol 3-bis(2-chloroethyl)carbamate|estramustine	A combination of the hormone estradiol (an estrogen) and nitrogen mustard (an anticancer drug). Used in the palliative therapy of prostate cancer.
C480	Estramustine_Phosphate_Sodium	Estramustine	Estramustine Phosphate Sodium|ESTRAMUSTINE PHOSPHATE SODIUM|Emcyt|Estracyt|Estramustine 17-(Dihydrogenphosphate) Disodium Salt|Estramustine Phosphate|Estramustine Sodium Phosphate|Estramustine phosphate|Estramustine sodium phosphate|Leo 299|Leo-299|Ro-21-8837/001	An orally-active carbamate ester combining 17 beta-estradiol and nor-nitrogen mustard with antineoplastic activity.  Estramustine phosphate sodium binds to microtubule-associated proteins (MAPs) and tubulin, thereby interfering with microtubule dynamics; causing cell cycle arrest; inhibiting tumor cell proliferation; inducing tumor cell apoptosis; and disrupting nuclear matrix and cell membranes.  Estramustine targets hormone-sensitive prostate cancer cells and exhibits mild estrogenic activity, although this property does not appear to be its primary mechanism of action.  This agent exhibits synergism in combination with other antimicrotubule agents. (NCI04)
C481	Antiestrogen	Hormone_Antagonist	Antiestrogen|Anti-Estrogens|Antiestrogenic|Antiestrogens|Estrogen Antagonist|Estrogen Inhibitor|antiestrogen	A substance that blocks the activity of estrogens, the family of hormones that promote the development and maintenance of female sex characteristics.
C482	Conjugated_Estrogens	Steroidal_Estrogen	Conjugated Estrogens|Conestron|Conjugated Estrogen - Premarin|Estrogens, Conjugated|Femest|Premarin|Sodestrin|Tag-39	Purified orally bioavailable female sex hormones isolated from pregnant mare urine or synthetically derived from plant materials and primarily conjugated as sulfate esters. Estrogen binds to and activates specific nuclear receptors, which, in turn, bind to estrogen response elements (EREs) in target genes, resulting in histone acetylation, alteration of chromatin conformation, and initiation of transcription. (NCI04)
C483	Therapeutic_Estrogen	Therapeutic_Hormone	Therapeutic Estrogen|Oestrogens	A class of natural or synthetic hormones that binds to a cytoplasmic receptor and initiates translocation of the hormone-receptor complex to the nucleus of target cells of tissues rich in estrogen receptors, including the endometrium, myometrium, oviduct, vagina, fallopian tube, cervix, brain, liver, placenta, ovarian cells, Leydigs cells, kidney, prostate, pancreas, heart, and skin. (NCI)
C484	Therapeutic_Estrone	Steroidal_Estrogen	Therapeutic Estrone|ESTRONE|Estrone|Oestrone|Theelin	A class of substances either naturally or synthetically derived forms of estrone.(NCI)
C485	Ethacrynic_Acid	Glutathione_Transferase_Inhibitor|Multidrug_Resistance_Modulator	Ethacrynic Acid|ETHACRYNIC ACID|Edecrin|Ethacrynic acid|[2,3-Dichloro-4-(2-methylene-1-oxobutyl)phenoxy]acetic Acid
C486	Ethinyl_Estradiol	Therapeutic_Estradiol	Ethinyl Estradiol|(17alpha)-19-Norpregna-1,3,5(10)-trien-20-yne-3,17-diol|Diogyn E|Diogyn-E|ETHINYL ESTRADIOL|Estinyl|Ethinoral|Ethinylestradiol|Eticylol|Feminone|Inestra|Lynoral|Orestralyn	A semisynthetic estrogen. Ethinyl estradiol binds to the estrogen receptor complex and enters the nucleus, activating DNA transcription of genes involved in estrogenic cellular responses. This agent also inhibits 5-alpha reductase in epididymal tissue, which lowers testosterone levels and may delay progression of prostatic cancer. In addition to its antineoplastic effects, ethinyl estradiol protects against osteoporosis. In animal models, short-term therapy with this agent has been shown to provide long-term protection against breast cancer, mimicking the antitumor effects of pregnancy. (NCI04)
C487	Ethiodized_Oil	Contrast_Agent	Ethiodized Oil|Ethiodol|Iodized Oil|Lipiodol	A synthetic iodine addition product of the ethyl ester of the fatty acids of poppyseed oil. Ethiodized oil contains 37% organically bound iodine and is used as a diagnostic radiopaque medium or, labeled with I-131, as an antineoplastic agent. Selectively retained in tumor vessels for long periods, ethiodized oil is used for imaging organs such as liver, lung, stomach, and thyroid. Labeled with I-131 or other beta emitters (Y-90 or P-32), ethiodol can deliver a high internal radiation dose to certain tumors with minimal effect on healthy tissues.
C488	Amifostine	Cytoprotective_Agent|Nephroprotective_Agent|Neuroprotective_Agent	Amifostine|2-[(3-Aminopropyl)amino]ethanethiol Dihydrogen Phosphate Ester|APAETP|Aminopropylaminoethylthiophosphoric Acid|Ethiofos|Ethyol|Gammaphos|S-(N-(3-Aminopropyl)-2-aminoethyl)thiophosphoric Acid|S-2-(3-Aminopropylamino)ethylphosphorothioic Acid|WR 2721|WR-2721|WR2721|YM-08310|amifostine	A drug used as a chemoprotective drug to control some of the side effects of chemotherapy and radiation therapy.
C489	Etoglucid	Miscellaneous_Alkylating_Agent	Etoglucid|1,2-Bis[2-(2, 3-epoxypropoxy)ethoxy]ethane|1,2-bis[2-(2,3-epoxypropoxy)ethoxy]ethane|1,2:15,16-Diepoxy-4,7,10, 13-tetraoxahexadecane|1,2:15,16-diepoxy-4,7,10,13-tetraoxahexadecane|2,2'-(2,5,8,11-tetraoxadodecane-1,12-diyl)bisoxirane|Epodyl|Ethane, 1, 2-bis[2-(2,3-epoxypropoxy)ethoxy]-|Ethoglucid|ICI 32865|ICI-32865|Triethylene glycol diglycidyl ether|triethylene glycol diglycidyl ether
C490	Ethylene_Dibromide	Carcinogenic_Brominated_Hydrocarbon|Pesticide	Ethylene Dibromide|1,2-Dibromoethane|EDB	A clear, colorless, volatile liquid brominated hydrocarbon with a mild, sweet, chloroform-like odor that emits corrosive and toxic fumes when heated to decomposition. Ethylene dibromide is used as a chemical intermediate in the synthesis of resins, waxes, gums, dyes and pharmaceuticals and is used to produce vinyl bromide. Exposure to ethylene dibromide severely irritates the skin and causes depression and collapse. Ethylene dibromide affects DNA integrity by alkylation and is reasonably anticipated to be a human carcinogen.
C491	Etoposide	Epipodophyllotoxin_Compound	Etoposide|4'-Demethylepipodophyllotoxin 9-[4,6-O-ethylidene-beta-D-glucopyranoside|9-[(4,6-O-Ethylidene-beta-D-glucopyranosyl]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one|Demethyl Epipodophyllotoxin Ethylidine Glucoside|EPEG|ETOPOSIDE|Lastet|NSC 141540|VP 16-213|VP-16|VP-16-213|Vepesid|etoposide	A semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum.  Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death.  Etoposide acts primarily in the G2 and S phases of the cell cycle. (NCI04)
C492	Fatty_Acid	Lipid	Fatty Acid|Fatty Acids|fatty acids	A major component of fats that are used by the body for energy and tissue development.
C493	Omega-3_Fatty_Acid	Fatty_Acid|Nutritional_Supplement	Omega-3 Fatty Acid|Omega-3 Fatty Acids|Omega-3 PUFA|Omega-3 Polyunsaturated Fatty Acid|omega-3 fatty acid|omega-3-Fatty Acids	A type of fat obtained in the diet and involved in immunity.
C494	Fentanyl	Opioid	Fentanyl|Duragesic|FENTANYL|fentanyl	A narcotic opioid drug that is used in the treatment of pain.
C495	Therapeutic_Interferon_Beta	Therapeutic_Interferon	Recombinant Interferon Beta|Beta Interferon|Beta Interferon Human (TRI)|Betantrone|Feron|Hu Rec Beta IFN (Berlex)|Human Interferon Beta (Mochida)|Interferon AlphaB (Human Leucocyte Protein Moiety Reduced)|Interferon Beta|Interferon Beta (IFN-B)|Interferon, Beta|Interferon-B|Naferon	A recombinant protein which is chemically identical to or similar to endogenous interferon beta with antiviral and anti-tumor activities. Endogenous interferons beta are cytokines produced by nucleated cells (predominantly natural killer cells) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes with an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral (the most important being inhibition of viral protein synthesis), antiproliferative and immune modulating effects. The recombinant therapeutic forms of interferon beta are interferon beta 1-a and interferon beta 1-b. (NCI05)
C496	Therapeutic_Fibroblast_Growth_Factor	Therapeutic_Growth_Factor	Recombinant Fibroblast Growth Factor	Family of structurally related polypeptides which have important roles in cell development, differentiation, and motility, as well as angiogenesis, neurogenesis, wound healing, and tumor growth.
C497	Fish_Oil	Food_Oil	Fish Oil|Seafood Oil|fish oils
C498	Fixative	Conceptual_Entities	Fixative|FIX	A compound that fixes tissues and cells for microscopic study.
C499	Flecainide	Adjuvant_Analgesic	Flecainide Acetate|FLECAINIDE ACETATE|Flecainide|flecainide	A drug that is used to treat abnormal heart rhythms. It may also relieve neuropathic pain, the burning, stabbing, or stinging pain that may arise from damage to nerves caused by some types of cancer or cancer treatment.
C500	Fluconazole	Antifungal_Agent	Fluconazole|Diflucan|FLUCONAZOLE|alpha-(2,4-difluorophenyl)-alpha- (1,2,4-triazol-1-ylmethyl)-1,2, 4- triazole-1-ethanol|fluconazole	A drug that treats infections caused by fungi.
C501	Flucytosine	Pyrimidine_Antagonist	Flucytosine|4-Amino-5-fluoro-2(1H)-pyrimidinone|5-FC|5-Fluorocytosine|Alcobon|Ancobon|Ancotil|FLUCYTOSINE|Ro 2-9915|Ro-2-9915|flucytosine	A drug that treats infections caused by fungi.
C502	Fluorine	Trace_Element	Fluorine	An element with atomic symbol F, atomic number 9, and atomic weight 19.0.
C503	Fluorochrome	Reagent	Fluorochrome|FLUCHM	A class of dyes when excited by light of certain wavelengths, emit photons and become fluorescent.  Fluorescence gives fluorochromes imaging characteristics and are used to label or stain biological structures.(NCI)
C504	Floxuridine	Pyrimidine_Antagonist	Floxuridine|1-(2-Deoxy-beta-D-ribofuranosyl)-5-fluorouracil|2'-Deoxy-5-fluorouridine|2-Deoxy-5-fluorouridine|5-FUDR|5-FUdR|5-Fluoro-2'-deoxy-beta-uridine|5-Fluoro-2'-deoxyuridine|5-Fluorodeoxyuridine|5-Fluorouracil Deoxyriboside|5-Fluorouracil deoxyriboside|5-Fluorouridine Deoxyribose|FDUR|FLOXURIDINE|FUDF|FUDR|FUdR|Floxuridin|Fluorodeoxyuridine|Fluorouridine Deoxyribose|Fluoruridine Deoxyribose|Fluoruridine deoxyribose|NSC 27640|NSC-27640|WR-138720|floxuridine	A fluorinated pyrimidine monophosphate analogue of 5-fluoro-2'-deoxyuridine-5'-phosphate (FUDR-MP) with antineoplastic activity. As an antimetabolite, floxuridine inhibits thymidylate synthetase, resulting in disruption of DNA synthesis and cytotoxicity.  This agent is also metabolized to fluorouracil and other metabolites that can be incorporated into RNA and inhibit the utilization of preformed uracil in RNA synthesis. (NCI04)
C505	Fluorouracil	Pyrimidine_Antagonist|Thymidylate_Synthase_Inhibitor	Fluorouracil|2,4-Dioxo-5-fluoropyrimidine|5-FU|5-Fluoro-2,4(1H, 3H)-pyrimidinedione|5-Fluoro-2,4(1H,3H)-pyrimidinedione|5-Fluorouracil|5-Fluracil|5-Fu|AccuSite|Actino-Hermal|Adrucil|Arumel|Cytosafe|Efudex|Efurix|FLUOROURACIL|Fiverocil|Fluoro Uracil|Fluoroplex|Fluouracil|Flurablastin|Fluracedyl|Fluracil|Fluril|Fluroblastin|Flurox|NSC 19893|NSC-19893|Ribofluor|Ro 2-9757|Ro-2-9757|Timazin|fluorouracil	(floor-o-YOOR-a-sil) An anticancer drug that belongs to the family of drugs called antimetabolites.  Also called 5-FU.
C506	Fluoxetine	Antidepressant_Agent|Antiemetic_Agent	Fluoxetine|N-methyl-gamma-(4-(trifluoromethyl) -phenoxy)-benzenepropanamine|fluoxetine	A drug used to treat depression.  It belongs to the family of drugs called antidepressants.
C507	Fluoxymesterone	Anabolic_Steroid|Therapeutic_Androgen	Fluoxymesterone|(11Beta,17beta)-9-fluoro-11,17-dihydroxy-17-methylandrost-4-en-3-one|11Beta,17beta-dihydroxy-9alpha-fluoro-17alpha-methyl-4-androsten-3-one|9Alpha-fluoro-11beta-hydroxy-17alpha-methyltestosterone|Androfluorene|Android-F|Androsterolo|FLUOXYMESTERONE|FXM|Halodrin|Halotestin|Ora Testryl|Ora-Testryl|Ora-testryl|Oratestin|Stenox|Testoral|Ultandren	A halogenated derivative of 17-alpha-methyltestosterone.  Similar to testosterone, fluoxymesterone binds to and activates specific nuclear receptors, resulting in an increase in protein anabolism, a decrease in amino acid catabolism, and retention of nitrogen, potassium, and phosphorus.  This agent also may competitively inhibit prolactin receptors and estrogen receptors, thereby inhibiting the growth of hormone-dependent tumor lines. Fluoxymesterone is approximately five times more potent than methyltestosterone. (NCI04)
C508	Flurbiprofen	Carbonic_Anhydrase_Inhibitor|Cyclooxygenase_Inhibitor	Flurbiprofen|2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid|Ansaid|BTS 18,322|E-7869|FLURBIPROFEN|MPC-7869|U-27,182
C509	Flutamide	Anti-Androgen	Flutamide|2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide|4'-Nitro-3'-trifluoromethylisobutyranilide|Alpha,alpha,alpha-trifluoro-2-methy-4'-nitro-m-propionotoluidide|Apimid|Chimax|Drogenil|Euflex|Eulexin|Eulexine|FLUT|FLUTAMIDE|Flucinom|Flucinome|Flugerel|Fluken|Flulem|Fluta-Gry|Flutabene|Flutacan|Flutamex|Flutamin|Flutan|Flutaplex|Fugerel|Grisetin|Niftolid|Oncosal|Profamid|Prostacur|Prostadirex|Prostica|Prostogenat|SCH 13521|Sch 13521|Tafenil|Tecnoflut|Testac|Testotard|flutamide	A toluidine derivative and nonsteroidal antiandrogen that is structurally related to bicalutamide and nilutamide. Flutamide and its more potent active metabolite 2-hydroxyflutamide competitively block dihydrotestosterone binding at androgen receptors, forming inactive complexes which cannot translocate into the cell nucleus. Formation of inactive receptors inhibits androgen-dependent DNA and protein synthesis, resulting in tumor cell growth arrest or transient tumor regression. (NCI04)
C510	Folic_Acid	B_Vitamin|Cytoprotective_Agent	Folic Acid|FA|FOLIC ACID|Folacin|N-(4-(((2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl)amino)benzoyl)-L-glutamic acid|N-[4-[[(2-Amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic Acid|Vitamin Bc|folic acid	A B-complex vitamin that is being studied as a cancer prevention agent. Also called folate.
C511	Folate_Antagonist	Antimetabolite	Folate Antagonist|Antifolates|Folate Analog|Folate Inhibitors|Folic Acid Analog|Folic Acid Antagonist|Folic Acid Antagonists|Folic Acid Inhibitors|antifolate|folate antagonist	A substance that blocks the activity of folic acid. Folate antagonists are used to treat cancer. Also called antifolate.
C512	Free_Radicals	Inorganic_Chemical	Free Radical|Free Radicals|free radicals	Highly reactive chemicals that often contain oxygen and are produced when molecules are split to give products that have unpaired electrons. This process is called oxidation. Free radicals can damage important cellular molecules such as DNA or lipids or other parts of the cell.
C513	Tegafur	Pyrimidine_Antagonist|Thymidylate_Synthase_Inhibitor	Tegafur|5-Fluoro-1-(tetrahydro-2-furanyl)-2,4(1H,3H)-pyrimidinedione|5-Fluoro-1-(tetrahydro-2-furanyl)-2,4-(1H,3H)-pyrimidinedione|5-Fluoro-1-(tetrahydro-2-furyl)-uracil|Citofur|Coparogin|Exonal|FT-207|Fental|Florafur|Fluorofur|Ftorafur|Ftoral|Ftoralon|Fulaid|Fulfeel|Furafluor|Furofutran|Futraful|Lamar|Lifril|MJF-12264|N1-(2'-Furanidyl)-5-fluorouracil|Neberk|Nitobanil|Riol|Sinoflurol|Sunfural|Tefsiel|Uracil, 5-fluoro-1-(tetrahydro-2-furyl)-|Utefos|WR-220066|tegafur	A congener of the antimetabolite fluorouracil with antineoplastic activity. Tegafur is a prodrug that is gradually converted to fluorouracil in the liver by the cytochrome P-450 enzyme. Subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells.  FdUMP inhibits DNA synthesis and cell division by inhibiting thymidylate synthase and reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate. (NCI04)
C514	Antifungal_Agent	Antibiotic	Antifungal Agent|Antifungal Drug|Antifungals|antifungals	Drugs that treat infections caused by fungi.
C515	Furosemide	Diuretic	Furosemide|FUROSEMIDE|LB 502|LB-502|Lasix|SK-Furosemide
C516	Ganglioside_GM2	Tumor_Antigen	Ganglioside GM2|GM2 ganglioside	Ganglioside GM2 (GM2) is a glycosphingolipid antigen expressed by a variety of human cancer cells. There are several reasons to consider GM2 as an attractive target for vaccine-based cancer immunotherapy: it is a surface antigen immunogenic in humans as indicated by the presence of naturally occurring serum antibodies, GM2-reactive antibodies are cytotoxic in vitro to GM2+ tumors, the feasibility of the induction of GM2 antibodies in melanoma patients following immunization with GM2 containing vaccines, and absence of deleterious effects associated with an immune response to GM2. Mutations in at least 1 of 3 recessive genes: HEXA, HEXB, and GM2A cause defects in GM2 catabolism, leading to lysosomal lipid storage disorders that manifest primarily as neurodegenerative diseases, including Tay-Sach's and Sandhoff Disease. (NCI)
C517	Ganciclovir	Nucleic_Acid_Synthesis_Inhibitor	Ganciclovir|2'-Nor-2'-deoxyguanosine|2'NDG|2-Amino-1,9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]-6H-purin-6-one|9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine|Cymevan|DHPG|GANCICLOVIR|Nordeoxyguanosine|Virgan|ganciclovir	A synthetic guanine derivative with antiviral activity.  As the active metabolite of ganciclovir, ganciclovir-5-triphosphate (ganciclovir-TP) appears to inhibit viral DNA synthesis by competitive inhibition of viral DNA polymerases and incorporation into viral DNA, resulting in eventual termination of viral DNA elongation.
C518	Ganglioside	Lipid	Ganglioside|ganglioside	A complex molecule that contains both lipids (fats) and carbohydrates (sugars) and is found in the plasma (outer) membrane of many kinds of cells.  Several different types of gangliosides have been identified.
C519	Gentamicin	Aminoglycoside_Antibiotic	Gentamicin|Garamicin|Garamycin|Genoptic|Genoptic S.O.P.|Gentamycin|U-Gencin
C520	Therapeutic_Glucagon	Miscellaneous_Hormone_Agent|Protein_Synthesis_Inhibitor	Therapeutic Glucagon|Antidiabetic Hormone|Glucagon|Hyperglycemic Glycogenolytic Factor	The recombinant form of the endogenous polypeptide hormone Glucagon consisting of 29 amino acids responsible for the release of stored glucose, causing increased blood glucose levels.  Clinical Use: Diagnostic Aid for Imaging Studies and Hypoglycemia.(NCI)
C521	Therapeutic_Glucocorticoid	Therapeutic_Corticosteroid	Therapeutic Glucocorticoid|Glucocorticoid	Synthetically derived forms of the naturally occurring Glucocorticoids.(NCI)
C522	Glutamine	Cytoprotective_Agent|Non-Essential_Amino_Acid	Glutamine|GLUTAMINE|GLUTAMINE,L-|Gln|Glutacerebro|Glutaven|L-Glutamine|Memoril|Q. Levoglutamide|glutamine	A nonessential amino acid. Glutamine can donate the ammonia on its side chain to the formation of urea (for eventual excretion by the kidneys) and to purines (necessary for the synthesis of nucleic acids). Glutamine may become a conditionally essential nutrient during certain catabolic states. (NCI04)
C523	Glutathione	Peptide	Glutathione Disulfide|GLUTATHIONE DISULFIDE|GSH|Glutathione|N-(N-L-gamma-glutamyl-L-cysteinyl)glycine	A tripeptide present in most cells comprised of three amino acids (cysteine, glutamic acid, and glycine) acting as an antioxidant, enhancing free radical scavenging, a detoxifying agent, binding to and transforming chemicals into excretable forms, a co-factor for some enzymes, and to boost the immune system.(NCI)
C524	Glycine	Non-Essential_Amino_Acid	Glycine|GLYCINE
C525	Glycophorin_A_Protein	Transmembrane_Protein	Glycophorin A Protein|CD235A|GPA|GYPA	Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups.  In addition to the M or N and S or s antigens, that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta; also, Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are resulted from gene recombinations between GYPA and GYPB. (from RefSeq)
C526	Glycyrrhetic_Acid	Cytoprotective_Agent	Glycyrrhetic Acid|(3beta,20beta)-3-Hydroxy-11-oxoolean-12-en-29-oic Acid|18-beta-Glycyrrhetinic Acid|Enoxolone|Glycyrrhetic acid|Glycyrrhetinic Acid|Glycyrrhetinic acid|beta-Glycyrrhetinic Acid
C527	Therapeutic_Gonadotropin	Pituitary_Agent	Recombinant Gonadotropin|Gonadotropic Hormone|Gonadotropins	A class of formulated therapeutic analogs of the endogenous gonadotropin that stimulates or promotes the function of the gonads.  Therapeutic gonadotropins are derived from animal or recombinant sources.  Gonadotropins include follicle-stimulating hormone, luteinizing hormone and chorionic gonadotropin.  These agents stimulate discrete cellular components of the gonads, exerting effects in both males and females. (NCI04)
C528	Therapeutic_Human_Chorionic_Gonadotropin	Therapeutic_Gonadotropin	Recombinant Human Chorionic Gonadotropin|Human Chorionic Gonadotropin|Novarel|Ovidrel|Pregnyl|Profasi|Therapeutic HCG|hCGH|rhCGH	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein hormone human chorionic gonadotropin (HCG).  HCG binds to cells of the corpus luteum, thereby stimulating progesterone production and helping to maintain a secretory endometrium. (NCI04)
C529	Gossypol	Antineoplastic_Plant_Product|Miscellaneous_Angiogenesis_Inhibitor|Protein_Kinase_C_Inhibitor	Gossypol|(2,2'-Binaphthalene)-8,8'-dicarboxaldehyde, 1,1',6,6'7, 7'-hexahydroxy-5,5'-diisopropyl-3,3'-dimethyl-|1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)[2,2'-binaphthalene]-8,8'-dicarboxaldehyde|1,1',6,6',7,7'-Hexahydroxy-5,5'-diisopropyl-3-3'-dimethyl[2,2'-binaphthalene]-8,8'-dicarboxaldehyde|2,2'-bis[1,6,7-Trihydroxy-4-methyl-5-isopropyl-8-aldehydonaphthalene|2,2'-bis[8-Formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene]|Cottonseed Meal Toxin|GOSSYPOL|gossypol	An anticancer drug extracted from the cotton plant.
C530	Therapeutic_Growth_Factor	Biological_Agent|Biological_Response_Modifier	Recombinant Growth Factor|Growth Agents	Formulated therapeutic proteins that are either isolated from endogenous sources or manufactured in a laboratory.  Growth factors bind to specific receptors expressed by various cell types, thereby stimulating cell differentiation and/or proliferation. (NCI04)
C531	Guanazole	Miscellaneous_Antimetabolite	Guanazole	A cytostatic triazole derivative antimetabolite. Guanazole scavenges tyrosine free radicals, thereby inhibiting mammalian ribonucleotide reductase activity and DNA synthesis. (NCI04)
C532	Guanine	Purine	Guanine|2-Amino-1,7-dihydro-6H-purin-6-one|2-Amino-6-Hydroxypurine	A purine base that is a constituent of nucleotides occuring in nucleic acids.(NCI)
C533	Guanosine	Nucleoside	Guanosine	A purine nucleoside formed from a beta-N9-glycosidic bond between guanine and a ribose ring and is essential for metabolism.
C534	Cyclic_GMP	Intracellular_Second_Messenger	Cyclic GMP|Guanosine Cyclic 3',5'-(Hydrogen Phosphate)|cGMP|cyclic 3',5'-guanosine monophosphate	A cellular regulatory agent that acts as a second messenger.  Its levels increase in response to a variety of signals (acetylcholine, insulin, oxytocin) and activates specific protein kinases.
C535	GDP	Nucleotides	GDP|Guanosine Pyrophosphate
C536	GTP	Nucleotides	GTP|Guanosine Triphosphate
C537	Haloperidol	Butyrophenone	Haloperidol|4-[4-(4-Chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-1-butanone|HALOPERIDOL|Haldol|McN-JR-1625|R 1625|R-1625
C538	Hemes	Porphyrin	Hemes
C539	Heparin	Anticoagulant_Agent	Heparin|heparin	A drug that helps prevent blood clots from forming. It belongs to the family of drugs called anticoagulants (blood thinners).
C540	Heparan_Sulfate	Heparin	Heparan Sulfate	Heparitin Sulfate.  A glycosaminoglycan, structurally similar to heparin but with more N-acetyl groups and fewer O- and N-sulfate groups. Occurs in the liver, aorta, and lung.  Accumulates in several mucopolysaccharidoses.
C541	Herbicide	Pesticide	Herbicide|herbicide	A chemical that kills plants.
C542	Heterocyclic_Compound	Ring_Compound	Heterocyclic Compound
C543	_2-Ring_Heterocyclic_Compound	Heterocyclic_Compound	2-Ring Heterocyclic Compound	A class of organic compounds containing two ring structures, one of which is made up of more than one kind of atom, usually carbon plus another atom. The heterocycle may be either aromatic or nonaromatic. (MeSH)
C544	Altretamine	Ethylenimine_Compound	Altretamine|2,4,6-Tris(dimethylamino)-s-triazine|2,4,6-tris(dimethylamino)-s-triazine|ALTRETAMINE|ENT 50852|ENT-50852|HMM|HXM|Hemel|Hexalen|Hexaloids|Hexamethylmelamine|Hexastat|Hexinawas|N,N,N',N',N",N"-hexamethyl-1,3,5-triazine-2,4,6-triamine|N,n,n',N"N"-hexamethyl-1,3,5,-triazine-2,4,6,-triamine|NSC 13875|RB-1515|WR-95704|altretamine|s-Triazine, 2,4,6-tris(dimethylamino)-	A synthetic cytotoxic s-triazine derivative similar in structure to alkylating agent triethylenemelamin with antineoplastic activity.  Although the precise mechanism by which altretamine exerts its cytotoxic effect is unknown, N-demethylation of altretamine may produce reactive intermediates which covalently bind to DNA, resulting in DNA damage. (NCI04)
C545	Hexestrol	Non-Steroidal_Estrogen	Hexestrol|(+-)-Hexestrol|(.+-.)-Hexestrol|(R*,S*)-4,4'-(1,2-Diethyl-1,2-ethanediyl)bis[phenol]	A synthetic hydrogenated derivative of diethylstilbestrol (DES). Hexestrol exhibits strong affinity for estrogen receptors that are overexpressed in some types of cancers.  When conjugated with a neoplastic drug, hexestrol may selectively concentrate the cytotoxic agent in estrogen receptor-rich tumors.  This agent may also be mutagenic. (NCI04)
C546	Pibenzimol	DNA_Minor_Groove_Binding_Agent|Topoisomerase-I_Inhibitor|Tubulin_Binding_Agent	Pibenzimol|Bisbenzimidazole|HOE 33258|Hoe 33258|Hoechst 33258|Hoechst Dye 33258|Hoechst dye 33258|Phenol, 4-(5-(4-methyl-1-piperazinyl)(2,5'-bi-1H-benzimidazol)-2'-yl)-, Trihydrochloride|Phenol, p-[5-[5-(4-methyl-1-piperazinyl)-2-benzimidazolyl]-2- benzimidazolyl]-, Trihydrochloride|Pibenzimol HCl|Pibenzimol Hydrochloride|Pibenzimol Hydrocholoride	A fluorescent dye of benzimidazole derivative.  Pibenzimol binds to AT-specific sites in the minor groove of duplex DNA and inhibits topoisomerase I, and DNA polymerase, thereby preventing DNA replication. This agent prolongs the G2 phase of the cell cycle and initiates apoptosis in tumor cells. (NCI04)
C547	Hormone_Antagonist	Pharmacologic_Substance	Hormone Antagonist|Antihormone Agents	Substances that inhibit or antagonize the function of the endocrine glands, the biosynthesis or biological effect of secreted hormones.(NCI)
C548	Therapeutic_Hormone	Pharmacologic_Substance	Therapeutic Hormone|Chemotherapy-Hormones/Steroids|Hormones	Treatment that adds, blocks, or removes hormones.  For certain conditions (such as diabetes or menopause), hormones are given to adjust low hormone levels.  To slow or stop the growth of certain cancers (such as prostate and breast cancer), hormones may be given to block the body's natural hormones.  Sometimes surgery is needed to remove the source of hormones.  Also called hormone therapy, hormonal therapy, or endocrine therapy.
C549	Hyaluronic_Acid	Glycosaminoglycan	Hyaluronic Acid	A glucosaminoglycan consisting of D-glucuronic acid and N-acetyl-D-glucosamine disaccharide units that is a component of connective tissue, skin, vitreous humour, umbilical cord, synovial fluid and the capsule of certain microorganisms contributing to adhesion, elasticity, and viscosity of extracellular substances.
C550	Hycanthone	Antihelminthic_Agent	Hycanthone|Etrenol|HYCANTHONE|Hycanthone Mesylate|Hycanthone mesylate	A thioxanthene derivative of lucanthone with anti-schistosomal activity and potential antineoplastic activity. Hycanthone interferes with parasite nerve function, resulting in parasite paralysis and death.  This agent also intercalates into DNA and inhibits RNA synthesis in vitro. (NCI04)
C551	Hydralazine	Antihypertensive_Agent	Hydralazine Hydrochloride|1(2H)-Phthalazinone Hydrazone|Apresoline|Apressin|HYDRALAZINE HYDROCHLORIDE|Hydralazine
C552	Hydrocarbon	Organic_Chemical	Hydrocarbon|Hydrocarbons	A group of organic compounds that consist of only hydrogen (H) and carbon (C) atoms and are involved in energy production. They may be cyclic or non-cyclic compounds. They may have double bonds, single bonds or both with carbon forming the backbone.
C553	Aromatic_Hydrocarbon	Aromatic_Compounds|Hydrocarbon	Aromatic Hydrocarbon
C554	Halogenated_Hydrocarbon	Hydrocarbon	Halogenated Hydrocarbon|Hydrocarbons, Halogenated	Compounds consisting of carbon, hydrogen, and one or more halogen.
C555	Therapeutic_Hydrocortisone	Therapeutic_Glucocorticoid	Therapeutic Hydrocortisone|(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione|Aeroseb-HC|Barseb HC|Barseb-HC|Cetacort|Cort-Dome|Cortef|Cortenema|Cortifan|Cortisol|Cortispray|Cortril|Dermacort|Domolene|Eldecort|HYDROCORTISONE|Hautosone|Heb-Cort|Hydrocortisone|Hydrocortone|Hytone|Komed-HC|Nutracort|Proctocort|Rectoid|hydrocortisone	A drug used to relieve the symptoms of certain hormone shortages and to suppress an immune response.
C556	Hydroxamic_Acids	Histone_Deacetylase_Inhibitor|Matrix_Metalloproteinase_Inhibitor	Hydroxamic Acids	A group of weak acids with the general chemical formula RC(=O)N(R')OH and antineoplastic and antimicrobial activities.  Hydroxamic acids covalently bind to the zinc(II) ion in the active sites of matrix metalloproteinases (MMP), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. (NCI04)
C557	Hydroxychloroquine	Antimalarial_Agent	Hydroxychloroquine|hydroxychloroquine	A 4-aminoquinoline with antimalarial and immunosuppressive properties. Although its precise mechanism of action is unknown, hydroxychloroquine may suppress immune function by interfering with the processing and presentation of antigens and the production of cytokines.  This agent is highly active against the erythrocytic forms of P. vivax and malariae and most strains of P. falciparum but not the gametocytes of P. falciparum. (NCI04)
C558	Hydroxyeicosatetraenoic_Acid	Eicosanoid	Hydroxyeicosatetraenoic Acid|HETE
C559	Hetastarch	Blood_Substitute	Hetastarch|Hespan
C560	Hydroxyurea	Miscellaneous_Antimetabolite|Ribonucleotide_Reductase_Inhibitor	Hydroxyurea|Droxia|HYDROXYUREA|Hydrea|Hydroxycarbamide|Litalir|Onco-Carbide|Onco-carbide|Oncocarbide|Oxeron|SQ 1089|SQ-1089|Syrea|WR 83799|hydroxyurea	A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle.  This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. (NCI04)
C561	Ibuprofen	Cyclooxygenase_Inhibitor	Ibuprofen|(.+ -.)-p-Isobutylhydratropic acid|Benzeneacetic Acid, Alpha-methyl-4-(2-methylpropyl)-|IBUPROFEN|Motrin|p-Isobutylhydratropic Acid|p-Isobutylhydratropic acid	A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic, and antipyretic effects. Ibuprofen inhibits the activity of cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. This leads to decreased prostaglandin synthesis, by prostaglandin synthase, the main physiologic effect of ibuprofen. Ibuprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation. (NCI05)
C562	Idarubicin	Anthracycline_Antibiotic	Idarubicin|(1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-hexopyranoside|(7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione|4-DMDR|4-Demethoxydaunomycin|4-Demethoxydaunorubicin|4-demethoxydaunorubicin|idarubicin	A semisynthetic anthracycline antineoplastic antibiotic derived from daunorubicin.  Idarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  Due to its high lipophilicity, idarubicin penetrates cell membranes better than other anthracycline antibiotics.  Idarubicin hydrochloride is the therapeutic form of this drug. (NCI04)
C563	Idoxuridine	Nucleic_Acid_Synthesis_Inhibitor|Pyrimidine_Antagonist	Idoxuridine|1-(2-Deoxy-beta-D-ribofuranosyl)-5-iodouracil|2'-Deoxy-5-iodouridine|5-Iodo-2'-deoxyuridine|Dendrid|Herplex|IDOXURIDINE|IUDR|IUdR|Idexur|Idoxene|Idulea|Iduridin|Iododeoxyuridine|Iododeoxyuridine (IUDR)|Kerecid|NSC 39661|SKF 14287|Stoxil|Virudox|idoxuridine	A drug that reduces the risk of cancer cell growth by interfering with the cells' DNA.
C564	Ifosfamide	Nitrogen_Mustard_Compound	Ifosfamide|2-oxo-N,3-bis-(2-chloroethyl) tetrahydro-2H-1,3,2-oxazaphosphorin- 2-amine|3-(2-chloroethyl)-2-[(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxide|Asta Z 4942|Asta Z-4942|Cyfos|Holoxan|Holoxane|IFO|IFO-Cell|IFX|Ifex|Ifolem|Ifomida|Ifomide|Ifosfamidum|Ifoxan|Iphosphamid|Iphosphamide|Iso-Endoxan|Isoendoxan|Isophosphamide|MJF 9325|MJF-9325|Mitoxana|N,3-bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide|NSC 109724|NSC-109724|Naxamide|Seromida|Tronoxal|Z 4942|Z-4942|ifosfamide	A synthetic analogue of the nitrogen mustard cyclophosphamide with antineoplastic activity. Ifosfamide alkylates and forms DNA crosslinks, thereby preventing DNA strand separation and DNA replication.  This agent is a prodrug that must be activated through hydroxylation by hepatic microsomal enzymes. (NCI04)
C565	IgA	Immunoglobulin	IgA	IgA is the immunoglobulin subclass that is associated with antibody-mediated mucosal immunity.  It is secreted as dimers into the mucosa and is the most effective isotype at fixing complement by the alternative pathway, even though it lacks the ability to fix complement by the classical pathway. There are two subtypes in the human - IgA1 and IgA2.
C566	IgD	Immunoglobulin	IgD	An immunoglobulin isotype (subclass).  This isotype is expressed on naive B cells along with IgM.  Little is known about its physiologic role.
C567	IgE	Immunoglobulin	IgE	An immunoglobulin isotype (subclass).  This isotype has the unique ability to bind with high affinity to IgE receptors (FceRI) on mast cells and basophils and induce degranulation and cytokine production by these cells when they are crosslinked by antigen.  In addition to a central role in atopy and allergic responses, it has been speculated that IgE-mediated mast cell degranulation, by its release of mediators that increase vascular permeability, has an important role in the initiation of immune response in general.
C568	IgG	Immunoglobulin	IgG	An immunoglobulin isotype (subclass) that characterizes secondary immune responses.  This isotype is further broken down into several smaller subclasses (IgG1, IgG2a, IgG2b, IgG3 in the mouse; IgG1-4 in the human), and each subclass is differentially synthesized and secreted into the serum upon differential immune stimuli.
C569	IgM	Immunoglobulin	IgM	The major immunoglobulin secreted during a primary immune response.  IgM binds with low affinity but high avidity (multiple binding sites) because it not only occurs as monomers but also as pentamers and hexamers.
C570	Imipenem	Beta-Lactam_Antibiotic	Imipenem|IMIPENEM|Imipemide|MK-0787|imipenem	A broad-spectrum, semi-synthetic beta-lactam carbapenem derived from thienamycin, produced by Streptomyces cattleya. Imipenem binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes that are involved in the last stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. This inactivation results in the weakening of the bacterial cell wall and eventually causes cell lysis. Imipenem has the greatest affinity for PBP 1A, 1B, and 2, and its lethal effect is related to binding to PBP 2 and 1B. This antibiotic is active against a wide range of gram-positive and gram-negative organisms and is stable in the presence of beta-lactamases. (NCI05)
C571	Antiserum	Biological_Agent|Biological_Response_Modifier	Antiserum	A blood serum or immunoglobulin fraction that contains antibodies against specific antigens obtained from previously immunized animals.
C572	Immunoglobulin	Antibody	Immunoglobulin|Immune Globulin|Immunoglobulins|Immunoglobulins / Antibodies|immunoglobulin	A protein that acts as an antibody.
C573	Surface_Immunoglobulin	Immunoglobulin	Surface Immunoglobulin|Surface Ig	Immunoglobulin containing a transmembrane region and expressed on the plasma membrane of a B cell.  Contrast with secreted Ig which has no transmembrane region but which can still be bound to the cell surface via Fc receptors.
C574	Immunosuppressant	Biological_Response_Modifier	Immunosuppressant|Immunosuppressive Agents|immunosuppressive	Describes the ability to lower immune system responses.
C575	Immunotoxin	Biological_Agent|Immunoconjugate	Immunotoxin|immunotoxin	Agents comprised of various toxic molecules (Radioactive Isotopes and Bacterial or Plant Toxins) conjugated with specific immune substances (Immunoglobulins, Monoclonal Antibodies, and Antigens)that targets affected cells allowing incorporation of the toxin into the cells.(NCI)
C576	Indomethacin	Cyclooxygenase_Inhibitor	Indomethacin|1-(4-chlorobenzoyl)-5-methoxy- 2-methyl-1-H-indole-3-acetic acid|INDOMETHACIN|Indocin|Indometacin|indomethacin	A drug that belongs to the family of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Indomethacin reduces pain, fever, swelling, and redness. It is also being used to reduce tumor-induced suppression of the immune system and to increase the effectiveness of anticancer drugs.
C577	Industrial_Waste	Industrial_Product	Industrial Waste
C578	Recombinant_Inhibins	Miscellaneous_Hormone_Agent	Recombinant Inhibins|Folliculostatin|Inhibins	Recombinant therapeutic agents chemically identical to or similar to endogenous glycoproteins which inhibit pituitary production of follicle-stimulating hormone (FSH).  Inhibins, designated as inhibin A and inhibin B, are secreted by the gonads and contribute to the control of gametogenesis, embryonic and fetal development and hematopoiesis.  As members of the transforming growth factor-B super family, the inhibins consist of dimers of two dissimilar protein subunits. (NCI04)
C579	Inorganic_Chemical	Drugs_and_Chemicals_Structural_Classification	Inorganic Chemical
C580	Inositol_1_4_5-Trisphosphate	Intracellular_Second_Messenger|Phosphatidylinositol	Inositol 1,4,5-Trisphosphate
C581	Therapeutic_Insulin	Miscellaneous_Hormone_Agent	Recombinant Insulin|Insulin	A synthetically- or animal-derived form of insulin used in the treatment of diabetes mellitus.  Therapeutic insulin is formulated to be short-, intermediate- and long-acting in order to individualize an insulin regimen according to individual differences in glucose and insulin metabolism.  Long-acting insulins are administered to complement short-acting insulins administered at mealtimes.  These agents may be derived from porcine, bovine or recombinant sources.  Endogenous human insulin, a pancreatic hormone composed of two polypeptide chains, is important for the normal metabolism of carbohydrates, proteins and fats; it has anabolic effects on many types of tissues. (NCI04)
C582	Intercalating_Agent	DNA_Binding_Agent	Intercalating Agent|DNA Intercalating Agent|Intercalating Ligand|Intercalator
C583	Therapeutic_Interferon_Gamma	Therapeutic_Interferon	Recombinant Interferon Gamma|Actimmune|Gamma Interferon (GEN)|Gamma Interferon-SCH|Gamma-Interferon|HU Gamma IFN (RU42369)|IFN-g|Immune Interferon Meloy|Interferon Gamma|Interferon Gamma (BIO)|Interferon, Gamma	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous lymphokine interferon gamma (IFN-gamma) with antineoplastic, immunoregulatory, and antiviral activities. Therapeutic IFN-gamma binds to and activates the cell-surface IFN-gamma receptor, stimulating antibody-dependent cytotoxicity and enhances natural killer cell attachment to tumor cells. This agent also activates caspases, thereby inducing apoptosis in malignant cells. (NCI04)
C584	Therapeutic_Interferon	Therapeutic_Cytokine	Recombinant Interferon|Human Leukocyte Interferon|Human Lymphoblastoid Interferon|Human lymphoblastoid interferon|IFN|Interferons	(in-ter-FEER-on) A biological response modifier (a substance that can improve the body's natural response to infection and disease). Interferons interfere with the division of cancer cells and can slow tumor growth. There are several types of interferons, including interferon-alpha, -beta, and -gamma. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases.
C585	Recombinant_Interleukin-1-beta	Therapeutic_Interleukin-1	Recombinant Interleukin-1-beta|IL-1-b|interleukin-1-beta	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous protein cytokine interleukin 1 (IL-1)-beta. Produced by monocytes and activated macrophages, endogenous mature IL-1 is generated through proteolytic cleavage by proteases such as IL-1-beta converting enzyme (ICE).  This agent promotes angiogenesis, fibroblast proliferation, and neutrophil chemotaxis; it also regulates the functions of lymphocytes and epithelial cells and is involved in the 'acute phase response' to infection. (NCI04)
C586	Therapeutic_Interleukin-1	Therapeutic_Interleukin	Recombinant Interleukin-1|IL-1|Interleukin 1|Interleukin-1|Lymphocyte Activating Factor|Lymphocyte-Stimulating Hormone|Macrophage Cell Factor	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-1 (IL-1). Produced mainly by monocytes, endogenous IL-1 plays a role in hematopoiesis, is a potent stimulator of T-cell activity, may promote or inhibit tumor growth, depending on tumor type. (NCI04)
C587	Therapeutic_Interleukin-2	Therapeutic_Interleukin	Recombinant Interleukin-2|IL-2|Interleukin 2, Recombinant|Interleukin II|Interleukin-2|Lymphocyte Mitogenic Factor|Mitogenic Factor|Recombinant interleukin-2|Ro-236019|T-Cell Growth Factor|TCGF|TSF|Thymocyte Stimulating Factor|interleukin-2	(in-ter-LOO-kin) IL-2. A type of biological response modifier (a substance that can improve the body's natural response to infection and disease) that stimulates the growth of certain disease-fighting blood cells in the immune system. These substances are normally produced by the body. Aldesleukin is IL-2 that is made in the laboratory for use in treating cancer and other diseases.
C588	Therapeutic_Interleukin-3	Therapeutic_Colony_Stimulating_Factor|Therapeutic_Interleukin	Recombinant Interleukin-3|Colony-Stimulating Factor 2 Alpha|Eosinophil-Mast Cell Growth-Factor|Erythrocyte Burst-Promoting Factor|IL-3|IL-3(H)|ILE-964|Interleukin-3|Interleukin-3 (IL-3)/ILE-964|MCGF|Mast-Cell Colony-Stimulating Factor|Multipotential Colony-Stimulating Factor	Interleukin-3. A type of biological response modifier (a substance that can improve the body's natural response to disease) that enhances the immune system's ability to fight tumor cells. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases.
C589	Therapeutic_Interleukin-4	Therapeutic_Interleukin	Recombinant Interleukin-4|B Cell Proliferating Factor|B-Cell Growth Factor|B-Cell Stimulating Factor|B-Cell Stimulatory Factor 1|BCGF|BCSF 1|IL-4|Interleukin-4|Interleukin-4 (Cell Genix)|MCGF 2|Mast Cell Growth Factor-2|T-Cell Growth Factor 2|interleukin-4	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-4 (IL-4). Produced primarily by activated T-cells, IL-4 binds to and activates its cell-surface receptor, stimulating the proliferation and differentiation of activated B-cells and enhancing their ability to present antigens to T-cells.  As a potential immunotherapeutic agent, recombinant IL-4 also augments the effects of other cytokines on dendritic cells (DC), cytotoxic T lymphocytes (CTL), and tumor-infiltrating lymphocytes (TIL). (NCI04)
C590	Therapeutic_Interleukin-5	Therapeutic_Interleukin	Recombinant Interleukin-5|B-Cell Growth Factor-II|BCGF-II|Eo-CSF|Eosinophil Differentiation Factor|IL-5|Interleukin 5|T-Cell Replacing Factor	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-5 (IL-5).  Produced by T cells, IL-5 stimulates the growth, differentiation, and activation of eosinophils, and promotes the conversion of B-cells into antibody- producing cells. (NCI04)
C591	Therapeutic_Interleukin-6	Therapeutic_Interleukin|Therapeutic_Neuropoietic_Cytokines|Therapeutic_Vascular_Endothelial_Growth_Factor	Recombinant Interleukin-6|B Cell Differentiation Factor 2|B-Cell Stimulatory Factor-2|HPGF|HSF|Hepatocyte Stimulating Factor|Hybridoma Growth Factor|IFN Beta 2|IL-6|Interleukin-6 (SERONO)|Myeloid Differentiation Inducing Protein|Plasmacytoma Growth Factor|Sigosix	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-6 (IL-6) with antiapoptotic, proinflammatory, and proangiogenic properties. IL-6 stimulates the production of vascular endothelial growth factor (VEGF), a proangiogenic substance.  High serum levels of interleukin-6 may indicate recurrence, metastasis, or progression in various cancers. (NCI04)
C592	Therapeutic_Interleukin-7	Therapeutic_Interleukin|Vaccine_Adjuvant	Recombinant Interleukin-7|CYT 99 007|IL-7|Lymphopoietin-1|Recombinant Human Interleukin-7	A recombinant protein which is chemically identical to or similar to endogenous interleukin-7 (IL-7) with hematopoietic and immunopotentiating properties. Produced by bone marrow, thymic stromal, and spleen cells, the cytokine interleukin-7 is a hematopoietic growth factor for progenitor B cells and T cells and stimulates proliferation and differentiation of mature T-cells and Natural Killer cells. (NCI05)
C593	Therapeutic_Interleukin	Therapeutic_Cytokine	Recombinant Interleukin|Interleukins	Formulated therapeutic analogs of one of a number of endogenous cytokine interleukins.  Produced by T cells, macrophages, and other cells, interleukins bind to a specific surface receptor on immunohematopoietic cells, thereby inducing a multitude of biologic effects including stimulation of growth, differentiation, and proliferation of lymphocytes and eosinophils; activation of lymphocytes and macrophages; enhancement of mast cell activity; activation of the acute phase response; and stimulation of hematopoiesis.  Some interleukins may enhance the host's immune response to malignant cells by stimulating lymphokine-activated killer (LAK) cells and tumor-infiltrating lymphocytes (TIL), which are capable of lysing some tumor cells. (NCI04)
C594	Iodine	Trace_Element	Iodine|I|iodine	An element that is necessary for the body to make thyroid hormone.  It is found in shellfish and iodized salt.
C595	Iodotyrosine	Tyrosine	Iodotyrosine|Monoiodotyrosine
C596	Ionomycin	Miscellaneous_Antibiotic	Ionomycin|ionomycin	A polyether antibiotic isolated from Streptomyces conglobatus sp.nov. Trejo exhibiting anti-cancer activity.  Ionomycin is a calcium ionophore that increases intracellular Ca++ levels, possibly relating to endonuclease activation of lymphocytes and decreased ratio of Bcl-2 to Bax and ultimately apoptosis.  In addition, this agent is used to investigate the role of intracellular calcium in cellular processes. (NCI)
C597	Ions	Inorganic_Chemical	Ion|Ions
C598	Iron	Metals	Iron|Fe|Niferex	An element with atomic symbol Fe, atomic number 26, and atomic weight 55.85.
C599	Isoflavone	Bioflavonoid|Phytoestrogen	Isoflavone|Isoflavones|isoflavones	Plant compounds that are found in soy products. Soy isoflavones are being studied to see if they help prevent cancer.
C600	Isoniazid	Antitubercular_Agent	Isoniazid|ISONIAZID	A synthetic derivative of nicotinic acid with anti-mycobacterial properties.  Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6.  Resistance occurs due to decreased bacterial wall penetration. (NCI04)
C601	Inosine_Pranobex	Immunostimulant	Inosine Pranobex|Aviral|Delimmun|Imunovir|Inosine Mono[4-(acetylamino)benzoate] Salt Compd with 1-(dimethylamino)-2-propanol(1:3)|Inosine:Dimethylaminoisopropanol Acetamidobenzoate(1:3)|Inosiplex|Isoprinosin|Isoprinosina|Isoprinosine|Methisoprinol|NP-113|NPT 10381|NPT-10381|Pranosina|Pranosine|Viruxan
C602	Isopropanol	Alcohol_Chemical_Class	Isopropanol|2-Propanol|ISOPROPYL ALCOHOL|Isopropanolol|Isopropyl Alcohol
C603	Isotretinoin	Retinoic_Acid_Agent	13-cis Retinoic Acid|13-cRA|13-cis retinoic acid|13-cis-Retinoate|13-cis-Retinoic Acid|13-cis-Vitamin A Acid|3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-cis-4-trans-6-trans-8-trans-nonatetraenoic Acid|3,7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexene-1-yl)2cis-4-trans-6-trans-8-trans-nonatetraenoic Acid|Accure|Accutane|Cistane|ISOTRETINOIN|Isotretinoin|Isotretinoinum|Isotrex|Isotrexin|Neovitamin A|Neovitamin A Acid|Oratane|Retinoic acid, 13-cis-|Retinoic acid, cis-|Retinoicacid-13-cis|Ro 4-3780|Ro-4-3780|Roaccutan|Roaccutane|Roacutan|cis-Retinoic Acid|isotretinoin	A drug that belongs to the family of drugs called retinoids. It is used in the treatment of acne and psoriasis and is being studied in cancer prevention. Also called isotretinoin.
C604	Ketanserin	Antiemetic_Agent	Ketanserin|3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-2,4[1H,3H]-quinazolinedione|Ketensin|R-41468|Serefrex|Sufrexal
C605	Ketoconazole	Anti-Androgen|Multidrug_Resistance_Modulator|Non-Steroidal_Aromatase_Inhibitor	Ketoconazole|Cis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazole-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazine|Fungarest|Fungoral|KETOCONAZOLE|Ketoderm|Ketoisdin|Nizoral|Orifungal M|Panfungol|R-41400|ketoconazole	A drug that treats infection caused by a fungus. It is also used as a treatment for prostate cancer because it can block the production of male sex hormones.
C606	Lactone_Compound	Organic_Chemical	Lactone Compound|LACTONE|Lactones	Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure, or analogues having unsaturation or heteroatoms replacing one or more carbon atoms of the ring (IUPAC).
C607	Leucovorin_Calcium	Folic_Acid_Derivative	Leucovorin Calcium|5-Formyl Tetrahydrofolate|5-Formyl-5,6,7,8-tetrahydrofolic Acid|5-Formyl-5,6,7,8-tetrahydropteroyl-L-glutamic Acid|Adinepar|Calcifolin|Calcium (6S)-Folinate|Calcium Folinate|Calcium Leucovorin|Calfolex|Calinat|Cehafolin|Citofolin|Citrec|Citrovorum Factor|Cromatonbic Folinico|Dalisol|Disintox|Divical|Ecofol|Emovis|FOLI-cell|Factor, Citrovorum|Flynoken A|Folaren|Folaxin|Foliben|Folidan|Folidar|Folinac|Folinate Calcium|Folinic Acid|Folinic Acid Calcium Salt Pentahydrate|Folinoral|Folinvit|Foliplus|Folix|Imo|Lederfolat|Lederfolin|Leucosar|Leucovorin|N-[4-[[(2-Amino-5-formyl-1,4,5,6,7,8-hexahydro-4-oxo-6-pteridinyl)methyl]amnio]benzoyl]-L-glutamic Acid|N-[p-[[(2-Amino-5-formyl-5,6,7,8-tetrahydro-4-hydroxy-6-pteridinyl)methyl]amino]benzoyl]glutamic Acid|Rescufolin|Rescuvolin|Tonofolin|Wellcovorin|leucovorin	A drug used to protect normal cells from high doses of the anticancer drug methotrexate. It is also used to increase the antitumor effects of fluorouracil and tegafur-uracil, an oral treatment alternative to intravenous fluorouracil.
C608	Leukotriene	Eicosanoid	Leukotriene
C609	Leukotriene_B4	Leukotriene	Leukotriene B4
C610	Levamisole	Chemo_Immunostimulant_Adjuvant	Levamisole|(S)-2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole|Ascaridil|Cloridrato de Levamizol|Decaris|Ergamisol|Ergamisole|I-Tetramisole|ICI-59623|Immunol|Ketrax|Levamisole Hydrochloride|R 12564|R-12564|RP-20605|Solaskil|Tramisol|Trimisol|l- Tetramisole Hydrochloride|l-Tetramisole hydrochloride|levamisole	An anthelmintic drug. Co-administered with fluorouracil in the treatment of Dukes' stage C colon cancer, levamisole restores immune function through stimulating antibody formation, enhancing T-cell activity, and potentiating macrophage function. (NCI04)
C611	Levodopa	Adjuvant_Analgesic	Levodopa|(-)-3-(3,4-Dihydroxyphenyl)-L-alanine|(--)-2Amino-3-)3,4-dihydroxyphenyl)propanoic Acid|(--)-3-(3,4-Dihydroxyphenyl)-L-alanine|.beta.-(3,4-Dihydroxyphenyl)-L-alanine|3-(3,4-Dihydroxyphenyl)-L-alanine|3-Hydroxy-L-tyrosine|Bendopa|Cidandopa|Deadopa|Dopaflex|Dopaidan|Dopal|Dopalina|Dopar|Doparkine|Doparl|Dopasol|Dopaston|Dopastral|Doprin|Eldopal|Eldopar|Eldopatec|Eurodopa|L(-)-Dopa|L-.beta.-(3,4-Dihydroxyphenyl)alanine|L-DOPA|L-Dopa|LEVODOPA|Laradopa|Larodopa|Ledopa|Levopa|Maipedopa|Parda|Veldopa|beta-(3,4-Dihydroxyphenyl)-L-alanine	An amino acid precursor of dopamine with antiparkinsonian properties. Levodopa is a prodrug that is converted to dopamine by DOPA decarboxylase and can cross the blood-brain barrier. When in the brain, levodopa is decarboxylated to dopamine and stimulates the dopaminergic receptors, thereby compensating for the depleted supply of endogenous dopamine seen in Parkinson's disease. To assure that adequate concentrations of levodopa reach the central nervous system, it is administered with carbidopa, a decarboxylase inhibitor that does not cross the blood-brain barrier, thereby diminishing the decarboxylation and inactivation of levodopa in peripheral tissues and increasing the delivery of dopamine to the CNS.
C612	Therapeutic_Luteinizing_Hormone	Therapeutic_Gonadotropin	Recombinant Luteinizing Hormone|Interstitial Cell-Stimulating Hormone|Leuteinizing Hormone|Luteinizing Hormone|Lutropin|Therapeutic LH
C613	Therapeutic_Gonadorelin	Miscellaneous_Hormone_Agent	Recombinant Gonadorelin|Abbott-41070|Cryptocur|D-His-6-Pro-8-NEt-LHRH|Factrel|Fertiral|GnRH|Gonadorelin|HRF|Kryptocur|LH-RH|Luforan|Lutrefact|Lutrelef|Lutrepulse|Pulsti|Relefact LH-RH|Relisorm L|Stimu-LH|Therapeutic GRH	A synthetic Luteinizing Hormone Releasing Hormone that binds to specific transmembrane glycoprotein receptors on gonadotrophic cells, stimulating synthesis and secretion of gonadotropins.  Continuous administration of Gonadorelin desensitizes the gonadotrophic cells.  Clinical Use: Hypothalamic Amenorrhea and Hypothalamic/Pituitary Function Evaluation.
C614	Lidocaine	Anesthetic_Agent	Lidocaine|.omega.-Diethylamino-2,6-dimethylacetanilide|2-(Diethylamino)-2',6'-acetoxylidide|2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide|2-Diethylamino-2',6'-acetoxylidide|Cuivasil|Duncaine|LIDOCAINE|Leostesin|Lidocaine HCl|Lidothesin|Lignocaine|Omega-diethylamino-2,6-dimethylacetanilide|Rucaina	A synthetic aminoethylamide with local anesthetic and antiarrhythmic properties. Lidocaine stabilizes the neuronal membrane by binding to and inhibiting voltage-gated sodium channels, thereby inhibiting the ionic fluxes required for the initiation and conduction of impulses and effecting local anesthesia.
C615	Linoleic_Acid	Omega-6_Fatty_Acid	Linoleic Acid|(Z,Z)-9,12-Octadecadienoic Acid|Linoleic acid	A polyunsaturated essential fatty acid found mostly in plant oils. It is used in the biosynthesis of prostaglandins and cell membranes.
C616	Lipid	Organic_Chemical	Lipid|Lipids	Lipids are fatty acid esters, an oily organic compound insoluble in water but soluble in organic solvents.
C617	Lomustine	Nitrosourea_Compound	Lomustine|1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea|1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea|1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-|Belustin|Belustine|CCNU|Cecenu|CeeNU|Chloroethylcyclo- hexylnitrosourea|Chloroethylcyclohexylnitrosourea|Citostal|LOMUSTINE|Lomeblastin|Lomustine (CCNU)|Lomustinum|Lucostin|Lucostine|N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea|N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea|NSC 79037|Prava|RB-1509|WR-139017|lomustine	A nitrosourea with antineoplastic activity. Lomustine alkylates and crosslinks DNA, thereby inhibiting DNA and RNA synthesis.  This agent also carbamoylates DNA and proteins, resulting in inhibition of DNA and RNA synthesis and disruption of RNA processing.  Lomustine is lipophilic and crosses the blood-brain barrier. (NCI04)
C618	Loperamide	Antidiarrheal_Agent	Loperamide	A synthetic agent chemically related to the opiates with anti-diarrheal properties.  Loperamide decreases gastro-intestinal motility by effects on the circular and longitudinal muscles of the intestine. Part of its anti-diarrheal effect may be due to a reduction of gastro-intestinal secretion produced by opioid receptor binding in the intestinal mucosa. (NCI04)
C619	Lorazepam	Benzodiazepine	Lorazepam|7-Chloro-5-(2-chlorophenyl)-1, 3-Dihydro-3-Hydroxy-1,4- Benzodiazepin-2-one|Ativan|LORAZEPAM	A benzodiazepine with anxiolytic, anti-anxiety, anticonvulsant, anti-emetic and sedative properties. Lorazepam enhances the effect of the inhibitory neurotransmitter gamma-aminobutyric acid on the GABA receptors by binding to a site that is distinct from the GABA binding site in the central nervous system. This leads to an increase in chloride channel opening events, a facilitation of chloride ion conductance, membrane hyperpolarization, and eventually inhibition of the transmission of nerve signals, thereby decreasing nervous excitation.
C620	Lovastatin	HMG-CoA_Reductase_Inhibitor|Ras_Inhibitor	Lovastatin|(2S)-2-Methylbutanoic Acid, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl Ester|LOVASTATIN|Lovastatin Sodium|Mevacor|Mevinolin|Monacolin K	A lactone metabolite isolated from the fungus Aspergillus terreus with cholesterol-lowering activity and potential antineoplastic activity. Lovastatin is hydrolyszed to the active beta-hydroxyacid form, which competitively inhibits 3-hydroxyl-3-methylgutarylcoenzyme A (HMG-CoA) reductase, an enzyme involved in the cholesterol biosynthesis.  In addition, this agent may inhibit tumor cell proliferation and reduce tumor cell invasiveness, thereby decreasing tumor metastatic potential; induce tumor cell apoptosis, possibly by inhibiting protein geranylgeranylation and; arrest cells in the G1 phase of the cell cycle, an effect that sensitizes tumor cells to the cytotoxic effects of ionizing radiation.  (NCI04)
C621	Therapeutic_Lymphokine	Therapeutic_Cytokine	Recombinant Lymphokine|Lymphokines	A type of cytokine produced by lymphocytes for therapeutic use involving cellular immunity.
C622	Therapeutic_Tumor_Necrosis_Factor-Beta	Therapeutic_Tumor_Necrosis_Factor_Family_Protein	Recombinant Tumor Necrosis Factor-Beta|Lymphotoxin A|Lymphotoxin Alpha|TNF beta|Tumor Necrosis Factor-Beta	A recombinant agent, which is chemically identical to or similar to the endogenous cytokine tumor necrosis factor-beta (TNF-beta). Produced predominantly by T-lymphocytes and leukocytes, TNF-beta is cytolytic or cytostatic for many tumor cells, and can inhibit the growth of endothelial cells, resulting in an antiangiogenic effect. (NCI04)
C623	Magnesium_Sulfate	Anticonvulsant_Agent	Magnesium Sulfate|Magnesium SO4|Magnesium Sulfate whiskers|Magnesium sulfate
C624	Manganese	Metals|Trace_Element	Manganese|Mn	An element with atomic symbol Mn, atomic number 25, and atomic weight 54.94.
C625	Mannitol	Diuretic	Mannitol|D-Mannitol|MANNITOL|Osmitrol|Resectisol
C626	Maytansine	Antineoplastic_Plant_Product|Tubulin_Binding_Agent	Maytansine|Alanine, N-acetyl-N-methyl-, 6-ester with 11-chloro-6, 21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9, 22-diazatetracyclo[19.3.1.1(10,24).0(3,5)]hexacosa-10,12,14[26], 16,18-pentaene-8,23-dione|L-Alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8, 23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03, 5]hexacosa-10,12,14(26),16,18-pentaen-6-yl ester, [1S-(1R*,2S*, 3R*,5R*,6R*,16E,18E,20S*,21R*)]-|L-alanine, N-acetyl-N-methyl-, 11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.110,14.03, 5]hexacosa-10,12,14(26),16,18-pentaen-6-yl ester, [1S-(1R*,2S*,3R*,5R*,6R*,16E,18E,20S*,21R*)]|Maitansine|Maysanine|Maytansin|NSC 153858|alanine, N-acetyl-N-methyl-, 6-ester with 11-chloro-6, 21-dihydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1(10,24).0(3,5)]hexacosa-10,12,14[26], 16,18-pentaene-8,23-dione	An ansamycin antibiotic originally isolated from the Ethiopian shrub Maytenus serrata. Maytansine binds to tubulin at the rhizoxin binding site, thereby inhibiting microtubule assembly, inducing microtubule disassembly, and disrupting mitosis.  Maytansine exhibits cytotoxicity against many tumor cell lines and may inhibit tumor growth in vivo. (NCI04)
C627	Nitrogen_Mustard	Nitrogen_Mustard_Compound	Mechlorethamine Hydrochloride|Bis(2-chloroethyl)methylamine|Caryolysine|Chloramin|Chlorethamine HCl|Chlorethazine|Chlorethazine Hydrochloride|Chlormethine|Chlormethine Hydrochloride|Chlormethine hydrochloride|Chloromethine HCl|Cloramin|Erasol|HN 2|MECHLORETHAMINE HYDROCHLORIDE|Mechlorethamine|Mechlorethamine HCl|Mechlorethamine hydrochloride|Methylbis(beta-chloroethyl)amine|Mustard|Mustargen|Mustargen HCl|Mustargen Hydrochloride|Mustargen hydrochloride|Mustine|Mustine Hydrochloride|Mustine hydrochloride|N-Lost|Nitrogen Mustard|Onco-Cloramin|WR-147650|chlorethamine hydrochloride|chlorethazine|chloromethine|ethanamine,2-chloro-N-(2-chloroethyl)-N-methyl|mechlorethamine|mechlorethamine HCl|methylchlorethamine	A synthetic agent related to sulphur mustard with antineoplastic and immunosuppressive properties. Nitrogen mustard (a member of a family of chemotherapy agents including cyclophosphamide and chlorambucil) is an irritant and carcinogenic agent metabolized to a highly reactive ethylene immonium derivative; the ethylene immonium derivative alkylates DNA and inhibits DNA replication. This agent also exhibits lympholytic properties. (NCI04)
C628	Mechlorethamine_Oxide_Hydrochloride	Nitrogen_Mustard_Compound	Mechlorethamine Oxide Hydrochloride|Mechlorethamine oxide hydrochloride	A nitrogen mustard alkylating agent that causes DNA cross linkages. It is a known carcinogen especially in mice. (NCI)
C629	Medroxyprogesterone	Therapeutic_Progestin	Medroxyprogesterone|(6Alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione|17Alpha-hydroxy-6alpha-methylprogesterone|6Alpha-methyl-17alpha-hydroxyprogesterone|6Alpha-methyl-4-pregnen-17alpha-ol-3,20-dione|Curretab|medroxyprogesterone	A hormonal anticancer drug that is also used in cancer prevention. It belongs to the family of drugs called progestins.
C630	Megestrol	Therapeutic_Progestin	Megestrol|Compound 5071|MEG|Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-|megestrol	A drug that belongs to the group of hormones called progestins, used as hormone therapy to block estrogen and to suppress the effects of estrogen and androgens. It is also used to stimulate the appetite in people with cancer.
C631	Melanin	Pigment	Melanin|melanin	(MEL-a-nin) The substance that gives color to skin and eyes.
C632	Therapeutic_Melatonin	Antioxidant|Chemo_Immunostimulant_Adjuvant|Miscellaneous_Hormone_Agent	Therapeutic Melatonin|Circadin|Melatonin	A recombinant therapeutic analog of melatonin, a natural serotonin-derived indole with antioxidant properties. Melatonin hormone synthesis occurs in the pineal gland and depends on beta-adrenergic receptor function. Melatonin is involved in numerous biological functions: circadian rhythm, sleep, stress response, aging, and immunity. (NCI04)
C633	Melphalan	Nitrogen_Mustard_Compound	Melphalan|4-[bis(2-chloroethyl)amino]-L-phenylalanine|Alanine Nitrogen Mustard|CB-3025|DL-O-Sarcolysin|L-PAM|L-Phenylalanine Mustard|L-Phenylalanine mustard|L-Sarcolysin|L-Sarcolysin Phenylalanine mustard|L-Sarcolysine|L-sarcolysin|MELPHALAN|Melphalanum|NSC 8806|Phenylalanine Mustard|Phenylalanine Nitrogen Mustard|Phenylalanine nitrogen mustard|Sarcoclorin|Sarkolysin|WR-19813|alanine nitrogen mustard|melfalan|melphalan|p-di(chloroethyl)amino-L-phenylalanine	An anticancer drug that belongs to the family of drugs called alkylating agents.
C634	Therapeutic_Human_Menopausal_Gonadotropin	Therapeutic_Gonadotropin	Recombinant Human Menopausal Gonadotropin|Human Menopausal Gonadotropin|Human Menopausal Gonadotropins|Humegon|Menotropins|Pergonal|Repronex|Therapeutic HMG
C635	Meperidine	Opioid	Meperidine Hydrochloride|Demerol|MEPERIDINE HYDROCHLORIDE|Meperidine
C636	Mestranol	Therapeutic_Estradiol	Mestranol|(17alpha)-3-Methoxy-19-norpregna-1,3,5(10)-trien-20-yn-17-ol|MESTRANOL	A semisynthetic estrogen. Metabolized by the liver to ethynyl estradiol, mestranol serves as the estrogen component in several combination oral contraceptives. (NCI04)
C637	Metals	Element_or_Isotope	Metal|Metals	Electropositive chemical elements characterised by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (On-line Medical Dictionary)
C638	Methadone	Opioid	Methadone Hydrochloride|Adanon|Althose|Dolophine|METHADONE HYDROCHLORIDE|Methadone|Methadone HCl|Methadose
C639	Mesylates	Organic_Chemical	Mesylates
C640	Methaqualone	Substance_of_Abuse	Methaqualone|2-Methyl-3-(2-methylphenyl)-4(3H)-quinazolinone|2-Methyl-3-o-tolyl-4(3H)-quinazolinone|3,4-Dihydro-2-methyl-4-oxo-3-o-tolylquinazoline|Cateudyl|Citexal|Dormigoa|Dormogen|Dormutil|Dorsedin|Fadormir|Holodorm|Hyminal|Hypcol|Hyptor|Ipnofil|MAOA|MTQ|Melsomin|Mequin|Metolquizolone|Mollinox|Motolon|Nobedorm|Noctilene|Normi-Nox|Omnyl|Optinoxan|Ortonal|Parest|Parminal|QZ 2|QZ-2|Quaalude|RIC 272|RIC-272|Rorer 148|Roulone|Rouqualone|Sindesvel|Somberol|Somnafac|Somnomed|Sonal|Soverin|TR 495|TR-495|Torinal|Tuazolone	A sedative, hypnotic agent that was used for insomnia, but was taken off of the market, in the U.S., in 1983 due to its high risk of abuse.(NCI)
C641	Methimazole	Antithyroid_Agent|Nephroprotective_Agent	Methimazole|Tapazole
C642	Methotrexate	Dihydrofolate_Reductase_Inhibitor|Folate_Antagonist	Methotrexate|4-Amino-10-methylfolic Acid|4-Amino-4-deoxy-10-methylpteroyl-L-glutamic Acid|Abitrexate|Alpha-Methopterin|Amethopterin|Brimexate|CL 14377|CL-14377|Emtexate|Emthexat|Emthexate|Farmitrexat|Fauldexato|Folex|Folex PFS|Lantarel|Ledertrexate|Lumexon|MTX|Maxtrex|Medsatrexate|Metex|Methoblastin|Methotrexate LPF|Methotrexate Methylaminopterin|Methotrexatum|Metotrexato|Metrotex|Mexate|Mexate-AQ|N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid|Novatrex|Rheumatrex|Texate|Tremetex|Trexeron|Trixilem|WR-19039|methotrexate	An anticancer drug that belongs to the family of drugs called antimetabolites.
C643	Methoxsalen	DNA_Crosslinking_Agent|Photosensitizing_Agent	Methoxsalen|8-MOP|8-Methoxypsoralen|9-Methoxy-7H-furo[3,2-g][1]benzopyran-7-one|Ammoidin|Deltasoralen|Dermox|Geralen|Geroxalen|METHOXSALEN|Meladinina|Meladinine|Methoxypsoralen|Metoxaleno|Mopsoralen|Oxsoralen|Oxsoralen-Ultra|Puvasoralen|Ultramop|Uvadex|XANTHOTOXIN|Xanthotoxin|methoxsalen	A drug used in ultraviolet light therapy.
C644	Methylene_Blue	Antifungal_Agent|Dye	Methylene Blue|Azul Metile|Azul de Metileno|Blu di Metilene|CI Basic Blue 9|CI-52015|Collubleu|Colour Index No. 52015|Desmoidpillen|Methylene blue|Methylenum Caeruleum|Methylthioninii Chloridum|Methylthioninium Chloride|Methylthioninium chloride|Schultz No. 1038|Tetramethylthionine Chloride Trihydrate|Urolene Blue|Vitableu	A synthetic basic dye. Methylene blue stains to negatively charged cell components like nucleic acids; when administered in the lymphatic bed of a tumor during oncologic surgery, methylene blue may stain lymph nodes draining from the tumor, thereby aiding in the visual localization of tumor sentinel lymph nodes. When administered intravenously in low doses, this agent may convert methemoglobin to hemoglobin.
C645	Methylnitrosourea	Carcinogenic_Nitrosourea|Nitrosourea_Compound	Methylnitrosourea|1-Methyl-1-nitrosourea|MNU|N-Methyl-N-nitrosourea|N-Nitroso-N-Methylurea|N-methyl-N-nitrosourea|N-nitroso-N-methylcarbamide|NMH|NMU|NSC 23909	A pale yellow, crystalline nitrosourea that is sensitive to light and moisture and emits toxic fumes of nitrogen oxides when heated to decomposition. Methylnitrosourea is an alkylating agent that is primarily used for research purposes to induce tumors and has also been studied as a chemotherapy agent for cancer treatment. Exposure to methylnitrosourea causes dermatitis. Methylnitrosourea is reasonably anticipated to be a human carcinogen. (NCI05)
C646	Methylphenidate	Miscellaneous_Adjuvant	Methylphenidate Hydrochloride|Concerta|METHYLPHENIDATE HYDROCHLORIDE|Methylphenidate|Methylphenidate HCl|Ritalin|Ritalin Hydrochloride|alpha-Phenyl-2-piperidineacetic Acid Methyl Ester|alpha-Phenyl-2-piperidineacetic Acid Methyl Ester Hydrochloride|methylphenidate	A drug that is a central nervous system stimulant.
C647	Methylprednisolone	Antiemetic_Agent|Therapeutic_Glucocorticoid	Methylprednisolone|(6alpha,11beta)-11,17,21-Trihydroxy-6-methylpregna-1,4-diene-3,20-dione|6Alpha-Methylprednisolone|Adlone|Caberdelta M|DepMedalone|Depo Moderin|Depo-Nisolone|Duralone|Emmetipi|Esametone|Firmacort|METHYLPREDNISOLONE|Medlone 21|Medrate|Medrol|Medrol Veriderm|Medrone|Mega-Star|Meprolone|Methylprednisolonum|Metilbetasone Solubile|Metrocort|Metypresol|Metysolon|Predni-M-Tablinen|Prednilen|Radilem|Sieropresol|Solpredone|Summicort|Urbason|Veriderm Medrol|Wyacort|methylprednisolone	A corticosteroid hormone replacement.
C648	Methyltestosterone	Therapeutic_Androgen	Methyltestosterone|(17Beta)-17-hydroxy-17-methylandrost-4-en-3-one|17 Alpha-methyl-delta4-androsten-17beta-ol-4-one|17-Methyltestosterone|Android|Eldec|Ero Test|Estratest|Glosso-Sterandryl|METHYLTESTOSTERONE|Malogen|Metandren|Methyltestosteronum|Neohombreol M|Orchisterone-M|Oreton Methyl|Oreton methyl|Testomet|Testotonic B|Testovis|Testred
C649	Metoclopramide	Antiemetic_Agent	Metoclopramide Hydrochloride|METOCLOPRAMIDE HYDROCHLORIDE|Metoclopramide|Reglan|metoclopramide	A drug that prevents or reduces nausea and vomiting.
C650	Metolazone	Diuretic	Metolazone|2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone|7-Chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo-6-quinazolinesulfonamide|7-Chloro-1,2,3,4-tetrahydro-2-methyl-4-oxo-3-o-tolyl-6-quinazolinesulfonamide|Diulo|METOLAZONE|Metenix|Mykrox|SR-720-22|Xuret|Zaroxolyn
C651	Metronidazole	Protein_Synthesis_Inhibitor|Trichomonacide_Agent	Metronidazole|Flagyl|METRONIDAZOLE|Metro I.V.|Satric|Tricom|metronidazole	A drug used to treat bacterial, fungal, and parasitic infections. It is also being studied in the treatment of some cancers.
C652	Mexiletine	Adjuvant_Analgesic	Mexiletine Hydrochloride|MEXILETINE HYDROCHLORIDE|Mexiletine
C653	Mezlocillin	Extended_Spectrum_Penicillin_Antibiotic	Mezlocillin|Mezlin
C654	Midazolam	Benzodiazepine	Midazolam Hydrochloride|8-Chloro-6-(2-fluorophenyl)-1-Methyl- 4H- Imidazo(1,5a)(1,4)Benzodiazepine|MIDAZOLAM HYDROCHLORIDE|Midazolam|Versed
C655	Mifepristone	Anti-Progestin	Mifepristone|(aa Beta, 17 beta)-11-[4-(dimethylamino)-phenyl]-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one|11 Beta-[4-(N,N-dimethylamino)phenyl]-17alpha-(propyl-1-ynyl)-delta-4,9-estradiene-17 beta-ol-3-one|11-((4-dimethylamino) phenyl)-17-Hydroxy-17-(1-propynyl) Estra-4,9- dien-3-one|MIFEPRISTONE|Mifegyne|Mifeprex|RU 486|RU-38486|mifepristone	A synthetic compound with antiprogesterone properties.  Mifepristone competitively binds to the progesterone receptor, leading to changes in the endometrial blood supply.  This agent also exhibits antiglucocorticoid and weak antiandrogenic activity. (NCI04)
C656	Mineral	Inorganic_Chemical	Mineral|Minerals|mineral
C657	Misonidazole	Bioreductive_Agent|Radiosensitizing_Agent	Misonidazole|1-(alpha-methoxymethyl ethanol)-2-Nitroimidazole|RO 7-0582|Ro-7-0582	A nitroimidazole with radiosensitizing and antineoplastic properties. Exhibiting high electron affinity, misonidazole induces the formation of free radicals and depletes radioprotective thiols, thereby sensitizing hypoxic cells to the cytotoxic effects of ionizing radiation. This single-strand breaks in DNA induced by this agent result in the inhibition of DNA synthesis. (NCI04)
C658	Plicamycin	DNA_Minor_Groove_Binding_Agent|Malignancy-Associated_Hypercalcemia_Inhibitor|Miscellaneous_Antineoplastic_Antibiotic	Plicamycin|A-2371|Aureolic acid|MTH|Mithracin|Mithracine|Mithramycin|PA-144	An antibiotic isolated from the bacterium Streptomyces plicatus with antineoplastic activity. Plicamycin, also known as mithramycin, binds to the minor groove of DNA at GC-rich sites, resulting in inhibition of RNA synthesis; this agent also inhibits mRNA expression, resulting in a reduction in protein synthesis. In addition, plicamycin may inhibit bone resorption by down regulating transcription of c-src, an oncogene involved in bone metabolism and resorption. (NCI04)
C659	Mitobronitol	Miscellaneous_Alkylating_Agent	Mitobronitol|Dibromomannitol|Myelobromol
C660	Mitogen	Physiology-Regulatory_Factor	Mitogen|MTGN	A soluble substance, usually a protein, that induces mitosis in resting cells, thereby causing cell proliferation.(NCI)
C661	Mitoguazone	Polyamine_Inhibitory_Agent|S-Adenosyl-Methionine_Decarboxylase_Inhibitor	Mitoguazone|1,1'-[(methylethanediylidene)dinitrilo)diguanidine|2,2"-(methyl-1,2-ethanediylidene)bis[hydrazinecarboximidamide]|DRG-0223|MGBG|Methyl GAG|Methyl-GAG|Methylglyoxal Bisguanylhydrazone|Methylglyoxal bis(amidinohydrazone)|Mitoguazone Dihydrochloride|NSC 32946|Zyrkamine|methylglyoxal bis(guanylhydrazone)|pyruvaldehyde bis(amidinohydrazone)	A guanylhydrazone with potential antineoplastic activity. Mitoguazone competitively inhibits S-adenosyl-L-methionine decarboxylase (SAMD), an enzyme involved in the synthesis of polyamines, resulting in decreased proliferation of tumor cells, antimitochondrial effects, and p53-independent apoptosis. Polyamines, specifically spermine and spermidine, are essential for thymidine kinase production, DNA synthesis, and cell proliferation. (NCI04)
C662	Mitolactol	Epoxide_Compound|Radiosensitizing_Agent	Mitolactol|6-Dibromodideoxydulcitol|6-Dibromodulcitol|DBD|Dibromdicil|Dibromodulcitol|Elobromol|Mitolac|mitolactol	A synthetic derivative of hexitol with antineoplastic and radiosensitizing properties.  Mitolactol alkylates DNA via actual or derived epoxide groups, resulting in inhibition of DNA and RNA synthesis. (NCI04)
C663	Mitomycin_Antibiotic	Antineoplastic_Antibiotic|Ethylenimine_Compound	Mitomycin Antibiotic|mitomycin	A class of anti-tumor antibiotics acting as alkylating agents. All mitomycins have the backbone of methyl, aziridine, pyrrolo, indole, and dione moieties. Bioreductively activated mitomycin antibiotics generate oxygen radicals and alkylate DNA, forming inter-strand cross-links and inhibiting DNA synthesis. (NCI04)
C664	Mitotane	Anti-Adrenal	Mitotane|(o,p)-DDD|1, 1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane|1,1-Dichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane|1-Chloro-2-[2,2-dichloro-1-(4-chlorophenyl)ethyl]benzene|2, 2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane|2, 4'-Dichlorodiphenyldichloroethane|2,2-Bis(2-chlorophenyl-4-chlorophenyl)-1,1-dichloroethane|2,4'-Dichlorodiphenyldichloroethane|2-(2-Chlorophenyl)-2-(4-chlorophenyl)-1,1-dichloroethane|CB 313|CB-313|Chloditan|Chlodithane|DDD|DDDS|Ethane, 2-(o-chlorophenyl)-2-(p-chlorophenyl)-1,1-dichloro-|Khloditan|Lisodren|Lysodren|MITOTANE|Mytotan|Ortho,para-DDD|WR-13045|mitotane|o,p' - DDD|o,p'-DDD	A synthetic derivative of the insecticide dichlorodiphenyl trichloroethane (DDT) with anti-adrenocorticoid properties.  Following its metabolism in the adrenal cortex to a reactive acyl chloride intermediate, mitotane covalently binds to adrenal proteins, specifically inhibiting adrenal cortical hormone production. (NCI04)
C665	Mitoxantrone	Anthraquinone_Compound	Mitoxantrone Hydrochloride|1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione|1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone|CL 232315|DHAD|DHAQ|Dihydroxyanthracenedione|Dihydroxyanthracenedione Dihydrochloride|MITOXANTRONE HYDROCHLORIDE|Mitoxantrone|Mitoxantrone Dihydrochloride|Mitoxantroni Hydrochloridum|Mitozantrone|Mitroxone|Neotalem|Novantrone|Onkotrone|Pralifan|mitoxantrone	An anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA replication.  This agent also binds to topoisomerase II, resulting in DNA strand breaks and inhibition of DNA repair.  Mitoxantrone is less cardiotoxic compared to doxorubicin. (NCI04)
C666	Molybdenum	Metals|Trace_Element	Molybdenum|Mo	An element with atomic symbol Mo, atomic number 42, and atomic weight 95.94.
C667	Monoamine_Oxidase_Inhibitor	Enzyme_Inhibitor	Monoamine Oxidase Inhibitor|MAO Inhibitors
C668	Mopidamol	Dihydropyrimidine_Dehydrogenase_Inhibitor	Mopidamol|2,2',2",2"'-[(4-Piperidinopyrimido[5,4-d-]pyrimidine-2,6-diyl)dinitrilo]tetraethanol|2,2',2",2"'-[[4-(1-Piperidinyl)pyrimido[5,4-d]pyrimidine-2,6-diyl]dinitrilo]tetrakisethanol|2,6-Bis(diethanolamino)-4-piperidino-pyrimido[5,4-d]pyrimidine|RA-233|Rapenton
C669	Morphine	Opiate	Morphine Sulfate|Avinza|Infumorph|Kadian|MORPHINE|MORPHINE SULFATE|MS Contin|MSir|Morphine|Oramorph|Oramorph SR|Roxanol|Statex SR|morphine	A narcotic drug used in the treatment of pain.
C670	Moxalactam	Beta-Lactam_Antibiotic	Moxalactam|Latamoxef|Ly 127935|Moxam
C671	Bischloroethylsulfide	Sulfur_Mustard_Compound	Bischloroethylsulfide	A sulfur mustard vesicant that had application in chemical warfare, treatment of psoriasis and has been studied as an alkylating agent in cancer therapy. (NCI)
C672	Mutagen	Chemical_Modifier	Mutagen
C673	Mycophenolic_Acid	Immunosuppressant|Miscellaneous_Antineoplastic_Antibiotic	Mycophenolic Acid|4-Hexenoic acid, 6-(1,3-dihydro-4-hydroxy-6-methoxy-7-methyl-3-oxo-5-isobenzofuranyl)-4-methyl-, (E)-|4-Hexenoic acid, 6-(4-hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-, (E)-|Acide mycophenolique|Acido micofenolico|Acidum mycophenolicum|Lilly-68618|Ly 68618|MPA	An antineoplastic antibiotic derived from various Penicillium fungal species.  Mycophenolic acid is an active metabolite of the prodrug mycophenolate mofetil.  Mycophenolic acid inhibits inosine monophosphate dehydrogenase (IMPDH), preventing the formation of guanosine monophosphate and synthesis of lymphocyte DNA that results in inhibition of lymphocyte proliferation, antibody production, cellular adhesion, and migration of T and B lymphocytes.  Mycophenolic acid also has antibacterial, antifungal, and antiviral activities. (NCI04)
C674	Mycotoxin	Nutritional_Toxin	Mycotoxin|Fungal Toxin	Mycotoxins are toxic, secondary metabolites of low molecular weight produced by naturally occurring fungi.  Mycotoxins are neither infectious nor contagious, but can occur on a herd-wide basis.
C675	NAD	Nucleotides	NAD|NAD+	Nicotinamide Adenine Dinucleotide, a coenzyme, found in eukaryotic cells and is involved in many enzymatic reactions and the production of energy through redox reactions.
C676	NADP	Nucleotides	NADP	Nicotinamide Adenine Dinucleotide Phosphate, an oxidation-reduction coenzyme, found in eukaryotic cells and is involved in many enzymatic reactions.
C677	Nafoxidine	Angiogenesis_Activator_Inhibitor|Selective_Estrogen_Receptor_Modulator	Nafoxidine|NFX	A triphenylethylene nonsteroidal agent that acts as a partial estrogen antagonist.  Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors.  This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue.  Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling. (NCI04)
C678	Naloxone	Opiate_Antagonist	Naloxone Hydrochloride|(-)-Naloxone|NALOXONE HYDROCHLORIDE|Naloxone|Narcan|naloxone	A substance that is being studied as a treatment for constipation caused by narcotic medications.  It belongs to the family of drugs called narcotic antagonists.
C679	Naltrexone	Opiate_Antagonist	Naltrexone Hydrochloride|(5alpha)-17-(Cyclopropylmethyl)-4,5-epoxy-3,14-dihydroxymorphinan-6-one|NALTREXONE HYDROCHLORIDE|Naltrexone|Naltrexone HCl|Naltrexone.HCl
C680	Naproxen	Cyclooxygenase_Inhibitor	Naproxen|6-Methoxy-alpha-methyl-2-naphthaleneacetic Acid|NAPROXEN|Naprosyn|RS-3540|d-2-(6-Methoxy-2-naphthyl)propionic Acid
C681	Opiate_Antagonist	Adjuvant	Opiate Antagonist|Narcotic Antagonist|Opioid Antagonist
C682	Zinostatin	DNA_Minor_Groove_Binding_Agent|Enediyne_Antitumor_Antibiotic	Zinostatin|Neocarzinostatin|Vinostatin	An enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore.  Zinostatin is isolated from the bacterium Streptomyces carzinostaticus.  The aminoglycoside component of zinostatin intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-strand breaks in DNA and apoptosis. (NCI04)
C683	Neomycin	Aminoglycoside_Antibiotic	Neomycin
C684	Therapeutic_Nerve_Growth_Factor	Therapeutic_Neurotrophic_Factor	Recombinant Nerve Growth Factor|Nerve Growth Factor|Therapeutic NGF	first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons; comprised of alpha, beta, and gamma subunits; beta subunit is responsible for its growth stimulating activity.
C685	Neuropeptide-Y	Neuropeptide	Neuropeptide Y|NPY|Neuropeptide Tyrosine	Encoded by single copy human NPY Gene (NPY Family), 97-aa 11-kDa (precursor) secreted Neuropeptide Y is a 36-aa peptide neuromodulator with sequence homology to peptide YY and PNP. One of the most abundant widespread peptides in the nervous system and found in some adrenal medulla chromaffin cells, NPY is one of the most highly conserved peptides known; only 3 amino acid differences exist between human and shark. Implicated in control of feeding, energy balance, and secretion of GNRH, NPY may also regulate angiogenesis. NPY regulates proliferation of multipotent postnatal neuronal precursor or basal cells by PKC-dependent rapid and transient activation of ERK1/2 MAP kinases (via NPY Y1 receptor subtype). (NCI)
C686	Neuropeptide	Protein_Organized_by_Function	Neuropeptide|neuropeptide	A member of a class of protein-like molecules made in the brain. Neuropeptides consist of short chains of amino acids, with some functioning as neurotransmitters and some functioning as hormones.
C687	Neurotransmitter	Physiology-Regulatory_Factor	Neurotransmitter	Endogenous signaling molecules that alter the behavior of neurons or effector cells. Neurotransmitter is used here in its most general sense, including not only messengers that act directly to regulate ion channels, but also those that act through second messenger systems, and those that act at a distance from their site of release. Included are neuromodulators, neuroregulators, neuromediators, and neurohumors, whether or not acting at synapses.
C688	Neurotoxin	Toxin	Neurotoxin|neurotoxin	A substance that is poisonous to nerve tissue.
C689	Niacin	B_Vitamin	Niacin|3-Pyridinecarboxylic Acid|NIACIN|Nicotinic Acid|Nicotinic acid|Vitamin B3	Water-soluble vitamin of the B complex occurring in various animal and plant tissues. Required by the body for the formation of coenzymes NAD and NADP. Has pellagra-curative, vasodilating, and antilipemic properties.
C690	Nickel	Carcinogenic_Metal|Metals|Trace_Element	Nickel|Metallic Nickel|Ni	An element with atomic symbol Ni, atomic number 28, and atomic weight 58.69.
C691	Nicotine	Alkaloid	Nicotine|(-)-Nicotine|(S)-3-(1-Methyl-2-pyrrolidinyl)pyridine|1-Methyl-2-(3-pyridyl)pyrrolidine|NICOTINE|beta-Pyridyl-alpha-N-methylpyrrolidine	An addictive CNS stimulant found in the tobacco plant that causes either ganglionic stimulation by depolarization in low doses or ganglionic blockage in high doses. (NCI)
C692	Nimodipine	Calcium_Channel_Blocker	Nimodipine|NIMODIPINE|Nimotop|nimodipine	A centrally acting analogue of the calcium channel blocker nifedipine. Nimodipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility.  This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI)
C693	Nimustine	Nitrosourea_Compound	Nimustine|ACNU|ACNU 50|N'-[4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitrosourea|Nidran|Nimustine Hydrochloride|Nimustine hydrochloride|Pimustine Hydrochloride	A nitrosourea with antineoplastic activity. Nimustine alkylates and crosslinks DNA, thereby causing DNA fragmentation, inhibition of protein synthesis, and cell death. (NCI05)
C694	Nitracrine	Acridine	Nitracrine
C695	Nitric_Oxide	Neurotransmitter	Nitric Oxide|Endothelium-Derived Relaxing Factor|NITRIC OXIDE	An unstable free-radical gas which reacts rapidly with oxygen to form nitrogen oxides.  Water soluble, NO is produced normally in numerous tissues and is considered to be a mediator of cell-to cell communication; it functions in numerous processes including vasodilation, inflammation, and neurotransmission. (NCI04)
C696	Nitriles	Nitrogen_Compound	Nitriles
C697	Nitrogen_Mustard_Compound	Mustard_Agent	Nitrogen Mustard Compound
C698	Nitrosamines	Nitrogen_Compound	Nitrosamine|Nitrosamines	Any of a class of organic compounds with the general formula R2NNO or RNHNO, present in various foods and other products and found to be carcinogenic in laboratory animals. (dictionary.com)
C699	Nitrosourea_Compound	Antineoplastic_Alkylating_Agent	Nitrosourea Compound|Nitrosourea Compounds|Nitrosoureas|nitrosoureas	(nye-TRO-so-yoo-REE-ahz) A group of anticancer drugs that can cross the blood-brain barrier. Carmustine and lomustine are nitrosoureas.
C700	Nogalamycin	Anthracycline_Antibiotic	Nogalamycin|NOGALAMYCIN|NSC 70845|U 15167|U-15167|[2R-(2alpha,3beta,4alpha,5beta,6alpha,11beta,13alpha,14alpha)-11-[(6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-alpha-L-mannopyranosyl)oxy]-4(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-2,6-epoxy-2H-naphthaceno[1,2-b]oxocin-14-carboxylic acid methyl ester	An anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces nogalater.  Nogalamycin intercalates into DNA and interacts with topoisomerase I, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)
C701	Nordihydroguaiaretic_Acid	Antioxidant	Nordihydroguaiaretic Acid|4,4'-(2,3-Dimethyl-1,4-butanediyl)bis[1,2-benzenediol]|Masoprocol|NDGA|Nordihydroguaiaretic acid
C702	Norethindrone	Therapeutic_Progestin	Norethindrone Acetate|Micronor|NORETHINDRONE ACETATE|Nor-Q.D.|Norethindrone|Norethindrone acetate|Norethisterone|Norethisterone Acetate|Norethisterone acetate|Norlutate|Norlutin
C703	Norgestrel	Therapeutic_Progestin	Norgestrel|(+/-)-13-Ethyl-17alpha-hydroxy-18,19-dinorpregn-4-en-20-yne-3-one|(17alpha)-(+/-)-13-Ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yne-3-one|NORGESTREL|Neogest|Ovrette|Wy-3707	A synthetic progestin commonly used alone or in combination with an estrogen for contraception.  Norgestrel suppresses the secretion of luteinizing and follicle-stimulating hormones (LH and FSH), thickens cervical mucus, and slows the transit of ova through the fallopian tubes.  This agent also exhibits antiproliferative activity in endometrial tissue and may exhibit chemopreventive and antineoplastic activities in endometrial carcinoma. (NCI04)
C704	Nortriptyline	Antidepressant_Agent	Nortriptyline Hydrochloride|NORTRIPTYLINE HYDROCHLORIDE|NortriSYyline|Nortriptyline HCl
C705	Novobiocin	Miscellaneous_Antibiotic	Novobiocin|NOVOBIOCIN|novobiocin	An antibiotic drug used to treat infection.
C706	Nucleic_Acids	Nucleic_Acids_Nucleosides_and_Nucleotides	Nucleic Acids|Nucleic Acid	A family of macromolecules, composed of various moiety: purines, pyrimidines, phosphoric acid, and a pentose, either d-ribose or d-deoxyribose. Nucleic acids in the form either DNA or RNA was found in the chromosomes, nucleoli, mitochondria, and cytoplasm of all cells, and in viruses.  Nucleic acids are the major players in controlling cellular function and heredity. (NCI)
C707	Nucleoside	Nucleic_Acids_Nucleosides_and_Nucleotides	Nucleoside	The constituent purine or pyrimidine bases of DNA or RNA with their corresponding deoxyribose or ribose sugars.
C708	Nucleic_Acids_Nucleosides_and_Nucleotides	Organic_Chemical	Nucleic Acids, Nucleosides, and Nucleotides
C709	Nucleotides	Nucleic_Acids_Nucleosides_and_Nucleotides	Nucleotide|Base|Nucleotides	A subunit of DNA or RNA consisting of a nitrogenous base (adenine, guanine, thymine, or cytosine in DNA; adenine, guanine, uracil, or cytosine in RNA), a phosphate molecule, and a sugar molecule (deoxyribose in DNA and ribose in RNA). (http://biotech.icmb.utexas.edu)
C710	Nystatin	Antifungal_Agent	Nystatin|Mycostatin|NYSTATIN|Nystex|mycostatin|nystatin	A drug that treats infections caused by fungi.
C711	Octreotide	Growth_Hormone_Release_Inhibiting_Factor	Octreotide|1,2-Dithia-5,8,11,14,17-pentaazacycloeicosane Cyclic Peptide Deriv|D-Phenylalanyl-L-cysteinyl-L-phenyl-alanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[2-hydroxy-1-(hydroxymethyl)propyl]-L-cysteinamide Cyclic (2-7)-Disulfide|D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-L-threoninol Cyclic (2-7)-Disulfide|D-Phenylalanyl-L-cysteinyl-L-phenylalanyl-D-tryptophyl-L-lysyl-L-threonyl-N-[(1R,2R)-2-hydroxy-1-(hyroxymethyl)propyl]-L-cysteinamide, Cyclic (2@7)-disulfide|Longastatin|Longastatina|Octreotide Acetate|Octreotide acetate|SMS 201-995|Samilstin|Sandostatin|Sandostatin Lar Depot|Sandostatina|Sandostatine|octreotide	A drug similar to the naturally occurring growth hormone inhibitor somatostatin. Octreotide is used to treat diarrhea and flushing associated with certain types of tumors.
C712	Ofloxacin	Quinolone_Antibiotic	Ofloxacin|OFLOXACIN|ofloxacin	A fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes involved in DNA replication and repair, resulting in cell death in sensitive bacterial species. (NCI04)
C713	Oligonucleotide	Deoxyribonucleic_Acid	Oligonucleotide|Oligo	Polymers made up of a few (2-20) nucleotides.
C714	Oligosaccharide	Polysaccharide	Oligosaccharide|Oligosaccharides
C715	Olivomycin_Antibiotic	Antineoplastic_Antibiotic|DNA_Minor_Groove_Binding_Agent|Tubulin_Binding_Agent	Olivomycin Antibiotic|OLIVOMYCIN|Olivomycins
C716	Omeprazole	Proton_Pump_Inhibitor	Omeprazole|5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole|5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole|H168/68|Losec|OMEP|OMEPRAZOLE|Prilosec|omeprazole	A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ - K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic properties and does not antagonize histamine H2 receptors.
C717	Oncolytic_Virus	Biological_Agent	Oncolytic Virus	Manipulated or engineered viruses having oncolytic properties to selectively replicate in and kill targeted cancer cells, leaving normal cells unharmed.
C718	Organic_Chemical	Drugs_and_Chemicals_Structural_Classification	Organic Chemical	Molecule that contains atoms of the element carbon, usually combined with itself and with atoms of one or more other element such as hydrogen, oxygen, nitrogen, sulfur, phosphorus, chlorine, or fluorine. Excludes carbides, carbonates and carbon oxides.(from EPA Terminology Reference System and Wikipedia)
C719	Organometallic_Compound	Organo-Metallic_Phosphorus_Boron_Derivatives	Organometallic Compound	A class of metal-containing organic compounds, where a C atom is joined directly to the metal.
C720	Oxacillin	Penicillin_Antibiotic	Oxacillin Sodium|OXACILLIN SODIUM|Oxacillin
C721	OxyContin	Retired_Concepts	OxyContin	OxyContin's active ingredient is oxycodone, a morphine-like substance that is also found in drugs like Percodan and Tylox. OxyContin Tablets are administered chronically to patients with cancer-related pain in a usual clinical setting.
C722	Oxygen	Element_or_Isotope	Oxygen	An element with atomic symbol O, atomic number 8, and atomic weight 16.
C723	Oxymetholone	Anabolic_Steroid|Therapeutic_Androgen	Oxymetholone|Adroyd|Anadrol|Anadrol-50 Anapolon|Anapolon|CL-406|HMD|HMDS|Hemogenin|Oxitosona|Plenastril|Synasteron
C724	Therapeutic_Oxytocin	Pituitary_Agent	Recombinant Oxytocin|OXYTOCIN|Oxytocin	A synthetic form of a natural posterior pituitary hormone that stimulates uterine smooth muscle contractions and mammary glands to cause ejection of milk. (NCI)
C725	Pancreatic_Polypeptide	Peptide	Pancreatic Polypeptide|Interacinar Cell Pancreatic Polypeptide
C726	Papaverine	Miscellaneous_Adjuvant	Papaverine|Cerebid|Cerespan|PAPAVERINE|Papaverine HCl|Pavabid|Pavacap|Pavatym|Unicelles|Vasal	An opiate alkaloid isolated from the plant Papaver somniferum and produced synthetically.  As a direct-acting smooth muscle relaxant, papaverine is not closely related to the other opium alkaloids in structure or pharmacological actions; its mechanism of action may involve the non-selective inhibition of phosphodiesterases and direct inhibition of calcium channels. This agent also exhibits antiviral activity against respiratory syncytial virus, cytomegalovirus, and HIV. (NCI04)
C727	Paraffin	Lipid	Paraffin|PARFF	Paraffin is a common name for a group of high molecular weight alkane hydrocarbons with the general formula CnH2n+2, where n is between 22 and 27. Paraffin is also a technical name for an alkane in general, but in most cases it refers specifically to a linear, or normal alkane. It is mostly found as a white, odorless, tasteless, waxy solid, with a melting point between 47C and 65C. It is insoluble in water, but soluble in ether, benzene, and certain esters. Paraffin is unaffected by most common chemical reagents but oxidizes readily. (from Wikipedia)
C728	Pefloxacin	Quinolone_Antibiotic	Pefloxacin
C729	Penicillamine	Angiogenesis_Activator_Inhibitor|Chemopreventive_Agent	Penicillamine|.beta.,.beta.-Dimethylcysteine|3-Mercapto-D-valine|Alpha-amino-beta-methyl-beta-mercaptobutyric Acid|Atamir|Beta,Beta-dimethylcysteine|Beta-thiovaline|Cuprenil|Cuprimine|Cupripen|D)-Penicillamine|D-Mercaptovaline|Depamine|Depen|Distamine|Kelatin|Mercaptyl|Metalcaptase|PENICILLAMINE|Pendramine|Perdolat|Sufortan|Trolovol|penicillamine	A beta dimethyl analog of the amino acid cysteine.  As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion.  Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. (NCI04)
C730	Penicillin_V	Penicillin_Antibiotic	Penicillin V Potassium|PENICILLIN V POTASSIUM|Pen-Vee|Penicillin V|Phenoxymethylpenicillin
C731	Pentamidine	Antifungal_Agent|Antiprotozoal_Agent	Pentamidine|Aerosolized Pentamadine|Pentamadine	A synthetic derivative of amidine with antiprotozoal and antifungal activities.  Although the precise mode of action of pentamidine is unclear, it appears to interact directly with the pathogen genome by binding to AT-rich regions of duplex DNA and the minor groove of DNA, thereby interfering with DNA replication. (NCI04)
C732	Pentostatin	Adenosine_Deaminase_Inhibitor|Purine_Antagonist	Pentostatin|(R)-3-(2-Deoxy-.beta.-D-erythro-pentofuranosyl)-3,6,7, 8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol|(R)-3-(2-Deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol|2'-Deoxycoformycin|2-Deoxycoformycin|CI-825|Co-Vidarabine|Co-vidarabine|Covidarabine|DCF|Deoxycoformycin|NSC 218321|Nipent|PD-81565|PENTOSTATIN|Pentostatine|pentostatin	A purine nucleotide analogue antibiotic isolated from the bacterium Streptomyces antibioticus. Also known as 2'-deoxycoformycin, pentostatin binds to and inhibits adenine deaminase (ADA), an enzyme essential to purine metabolism; ADA activity is greatest in cells of the lymphoid system with T-cells having higher activity than B-cells and T-cell malignancies higher ADA activity than B-cell malignancies. Pentostatin inhibition of ADA appears to result in elevated intracellular levels of dATP which may block DNA synthesis through the inhibition of ribonucleotide reductase. This agent may also inhibit RNA synthesis and may selectively deplete CD26+ lymphocytes. (NCI04)
C733	Pentoxifylline	Anticachexia_Agent|Antiplatelet_Agent	Pentoxifylline|3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione|Oxpentifylline|PENTOXIFYLLINE|Pentoxyphylline|Trental|pentoxifylline	A drug used to prevent blood clotting and as a treatment that may help decrease weight loss in people with cancer.
C734	Peptichemio	Miscellaneous_Antimetabolite|Nitrogen_Mustard_Compound	Peptichemio|Multialchilpeptide|peptide bound m-L-sarcolysine
C735	Peptide	Amino_Acid_Peptide_or_Protein	Peptide|Polypeptide|peptide	Any compound consisting of two or more amino acids, the building blocks of proteins. Peptides are combined to make proteins.
C736	Pertussis_Toxin	Bacterial_Toxin	Pertussis Toxin	Any of various biologically active proteins or toxins elaborated by Bordetella pertussis that cause the symptoms of whooping cough. Some activate pancreatic islets, others inhibit the adenylate cyclase cascade and some cause lymphocytosis.
C737	Pesticide	Industrial_Product	Pesticide|Pesticides	General term for an agent that destroys fungi, insects, rodents, or any other pest.
C738	Phencyclidine	Substance_of_Abuse	Phencyclidine|PCP	Phencyclidine (PCP) was developed as an anesthetic for humans in 1959. Its use was discontinued due to extreme side effects that included delirium, confusion, visual disturbances, hallucinations and violence. Some evidence of long-term memory disorders and schizophrenia-like syndrome have been observed. It is a substance of abuse, combining effects produced by depressants, stimulants, and hallucinogens. Can cause physical and psychological distress, coma, seizures and convulsions, respiratory depression, and cardiac problems.  In addition, phencyclidine is a notorious street drug known as "angel dust."(NCI)
C739	Phenobarbital	Anticonvulsant_Agent	Phenobarbital|5-Ethyl-5-phenyl-2,4,6(1H,3H,5H)-pyrimidinetrione|PHENOBARBITAL|phenobarbital	A sedative/anticonvulsant barbiturate that has been used to treat diarrhea and to increase the antitumor effect of other therapies.
C740	Phenothiazine	Antiemetic_Agent	Phenothiazine	A class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities.  Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis.  In addition, these agents have peripherally or centrally antagonistic activity against alpha adrenergic, serotonergic, histaminic, and muscarinic receptors. (NCI)
C741	Phenytoin	Anticonvulsant_Agent	Phenytoin|5,5-Diphenyl-2,4-imidazolidinedione|Dilantin|Diphenylhydantoin|PHENYTOIN
C742	Phorbol_Ester	Ring_Compound	Phorbol Ester	Polycyclic compound isolated from croton oil in which two hydroxyl groups on neighboring carbon atoms are esterified to fatty acids. The commonest of these derivatives is phorbol myristoyl acetate (PMA). Potent co carcinogens or tumor promotors, they are diacyl glycerol analogs and activate protein kinase C irreversibly. (On-line Medical Dictionary)
C743	Phosphatidylinositol	Lipid	Phosphatidylinositol	A phosphatidic acid combined with inositol found in biomembranes and a precursor to certain cellular signals. Sometimes referred to as inositide. It is a very important minor phospholipid in eukaryotes, involved in signal transduction processes. Contains myo inositol linked through the 1 hydroxyl group to phosphatidic acid. The 4 phosphate (PIP) and 4, 5 bisphosphate derivatives PIP2) are formed and broken down in membranes by the action of specific kinases and phosphatases (futile cycles). Signal sensitive phospholipase C enzymes remove the inositol moiety, in particular from 1,4,5 trisphosphate (PIP2) as inositol 1,4,5 triphosphate (Ins P3: IP3). Both the diacyl glycerol and products act as second messengers. (On-line Medical Dictionary)
C744	Phosphodiesterase_Inhibitor	Enzyme_Inhibitor	Phosphodiesterase Inhibitor
C745	OK-432	Chemo_Immunostimulant_Adjuvant	OK-432|Picibanil
C746	Picoline_Compound	Antineoplastic_Alkylating_Agent	Picoline Compound|Picoline	A group of isomeric compounds that are monomethyl derivatives of pyridines derived from coal tar, horse urine, and bone oil.
C747	Pigment	Drugs_and_Chemicals_Functional_Classification	Pigment|pigment	A substance that gives color to tissue. Pigments are responsible for the color of skin, eyes, and hair.
C748	Pilocarpine	Miscellaneous_Chemoprotective_Agent	Pilocarpine Hydrochloride|PILOCARPINE HYDROCHLORIDE|Pilocarpine|pilocarpine	A drug used to increase salivation in people who have dry mouth caused by opioids or radiation therapy. Pilocarpine belongs to the family of drugs called alkaloids.
C749	Piperacillin	Extended_Spectrum_Penicillin_Antibiotic	Piperacillin Sodium|CL 227, 193|PIPERACILLIN SODIUM|Piperacillin|Pipracil|T-1220
C750	Pipobroman	Miscellaneous_Alkylating_Agent	Pipobroman|Vercyte
C751	Piroxicam	Cyclooxygenase_Inhibitor	Piroxicam|4-Hydroxy-2-methyl-N-2-pyridinyl-2H-1,2-benzothiazine-3-carboximide-1,1-dioxide|Feldene|PIROXICAM
C752	Pituitary_Hormone	Peptide_Hormone	Pituitary Hormone	Pituitary hormones are produced by the pituitary gland, the master gland of the endocrine system which is located at the base of the brain. Levels of pituitary hormones are regulated by the hypothalamus, anterior and posterior lobes of the pituitary gland, and by the pars intermedia.
C753	Placebo	Clinical_Study_Element	Placebo|PBO|placebo|sham therapy	An inactive substance, treatment or procedure that is intended to provide baseline measurements for the experimental protocol of a clinical trial.(NCI)
C754	Plasmid	Deoxyribonucleic_Acid	Plasmid|Plasmids	A small cellular inclusion consisting of a ring of DNA that is not in a chromosome but is capable of autonomous replication.
C755	Therapeutic_Platlet-Derived_Growth_Factor	Therapeutic_Growth_Factor	Recombinant Platlet-Derived Growth Factor|Platlet-Derived Growth Factor|rPDGF	Expressed in platelets, human Platelet-Derived Growth Factor (PDGF/VEGF Family) is a mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released upon wounding to stimulate adjacent cell growth. PDGF can exist as antiparallel disulfide-linked homodimers (PDGFA, PDGFB) or heterodimers (PDGFA/PDGFB) that bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. (NCI)
C756	Platinum	Metals	Platinum|Pt|platinum	A metal that is an important component of some anticancer drugs, such as cisplatin and carboplatin.
C757	Poly_AU	Immunostimulant	Poly AU|Poly A:U|Polyadenylic Polyuridylic Acid	A synthetic polyadenylic-polyuridylic acid double-stranded RNA. Poly AU may stimulate the release of cytotoxic cytokines and, by inducing the production of interferon, may increase the number and tumoricidal activities of various immunohematopoietic cells. (NCI04)
C758	Poly_IC	Immunostimulant	Poly IC|5'-Inosinic Acid, Homopolymer Complex with 5'-Cytidylic Acid Homopolymer|Poly C poly I|Poly I:C|Poly I:poly C|Poly rI:poly rC|Poly(I).poly(C)|Poly(rI)-poly(rC)|Poly(rI).poly(rC)|Polyinosinic acid.polycytidylic acid|Polyinosinic acid:polycytidylic acid|Polyinosinic-polycytidylic Acid|poly (I)-poly (C)|poly (I).poly (C)|poly (rI)- poly (rC)|poly (rI). poly (rC)|poly I-poly C|poly I.poly C|polyinosate-polycytidylate|polyinosate.polycytidylate|polyinosinic acid-polycytidylic acid|polyinosinic acid.polycytidylic acid	A synthetic polyinosinic-polycytidylic acid double-stranded RNA. Poly IC may stimulate the release of cytotoxic cytokines and, by inducing interferon-gamma production, may increase the number and tumoricidal activities of various immunohematopoietic cells. (NCI04)
C759	Polyamine_Compound	Nitrogen_Compound	Polyamine Compound	A class or organic compounds composed of carbon, hydrogen, and nitrogen containing two or more amino groups with some compounds acting as essential growth factors for microorganisms.
C760	Polychlorinated_Biphenyl	Aromatic_Hydrocarbon|Carcinogenic_Chlorinated_Hydrocarbon	Polychlorinated Biphenyl|Chlorinated Biphenyls|Chlorinated Biphenylsl|Chlorobiphenyls|PCB|PCBs	Polychlorinated Biphenyls (PCBs) are a family of more than 200 chemical compounds (congeners) with 1 to 10 chlorine atoms attached to biphenyl and a general structure of C12H10-xClx. PCBs were commercially produced as complex mixtures of congeners at different degrees of chlorination for a variety of applications. Their use was based on their chemical stability, and desirable physical properties. According to WHO, several congeners are now considered to be "dioxin-like" because of their toxicity and certain features of their structure similar to 2,3,7,8-tetrachlorodibenzo-p-dioxin. PCBs are not readily biodegradable, their use declined and was essentially terminated because of environmental concerns. USA stopped producing PCBs in 1977. (NCI)
C761	Polycyclic_Aromatic_Hydrocarbons	Aromatic_Hydrocarbon	Polycyclic Aromatic Hydrocarbons	Polycyclic aromatic hydrocarbons (PAH) are a large class of organic compounds containing two or more fused aromatic rings made up of carbon and hydrogen atoms. They have high melting and boiling-points, low vapour pressure, water solubility, and are highly lipophilic. PAH are produced during incomplete combustion or pyrolysis of organic matter, are found in cigarette smoke, motor vehicle exhaust, used motor lubricating oil, broiled meat, coal tar, crude oil, creosote, roofing tar, dyes, plastics, and pesticides. Some members of PAH class were shown to have carcinogenic, genotoxic, and immunotoxic properties, developmental toxicity and affect reproductive health. (NCI)
C762	Polyethylene_Glycol	Drug_Vehicle	Polyethylene Glycol|Glycol, Polyethylene|Glycol, polyethylene|Polyethylene Glycol 400|Polyethylene Glycol 8000
C763	Porfiromycin	Mitomycin_Antibiotic	Porfiromycin|Azirino[2',3':3,4]pyrrolo[1, 2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a, 8b-hexahydro-8-(hydroxymethyl)-8a- methoxy-1,5-dimethyl-, carbamate (ester) (8CI)|Azirino[2',3':3,4]pyrrolo[1, 2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a, 8b-hexahydro-8-(hydroxymethyl)-8a- methoxy-1,5-dimethyl-, carbamate (ester)(8CI)|Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b- hexahydro-8a-methoxy-1,5-dimethyl-,[1aR-(1a.alpha.,8.beta., 8a.alpha.,8b.alpha.)]- (9CI)|Azirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-,[1aR-(1a.alpha.,8.beta., 8a.alpha.,8b.alpha.)]- (9CI)|ENT-50825|MITOMYCIN, METHYL|Methyl Mitomycin|Methyl Mitomycin C|Methyl mitomycin C|Methylmitomycin|Mitomycin, methyl-|N-Methylmitomycin C|N-methylmitomycin C|Porfiromycine|Porphyromycin|Promycin|U-14743|[1aS-(1a alpha,8beta,8a alpha,8b alpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione|porfiromycin	An N-methyl derivative of the antineoplastic antibiotic mitomycin C isolated from the bacterium Streptomyces ardus and other Streptomyces bacterial species.  Bioreduced porfiromycin generates oxygen radicals and alkylates DNA, producing interstrand cross-links and single-strand breaks, thereby inhibiting DNA synthesis.  Porfiromycin is preferentially toxic to hypoxic cells. (NCI04)
C764	Porphyrin	Heterocyclic_Compound|Pigment	Porphyrin
C765	Potassium	Electrolytes|Element_or_Isotope	Potassium|K|Potassium (NOS)|potassium	(po-TASS-ee-um) A metallic element that is important in body functions such as regulation of blood pressure and of water content in cells, transmission of nerve impulses, digestion, muscle contraction, and heartbeat.
C766	Povidone-Iodine	Miscellaneous_Antibiotic	Povidone-Iodine|Betadine|Iodine Povidone Topical|PVP iodine|PVP-Iodine|Povidone iodine|Povidone-iodine
C767	Prazosin	Adjuvant_Analgesic	Prazosin|1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-(2-furanylcarbonyl)piperazine|2-[4-(2-furoyl)piperazin-1-yl]-4-amino-6,7-dimethoxyquinazoline|Furazosin	A synthetic piperazine derivative with hypotensive antiadrenergic properties, Prazosin reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. (NCI)
C768	Prednimustine	Nitrogen_Mustard_Compound	Prednimustine|(11beta-21-[4-[4-[bis(2-chloroethyl)amino]phenyl]-1-oxobutoxy]-11,17-dihydroxypregna-1,4-diene-3,20-dione|11beta,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-[4-[p-[bis(3-chloroethyl)amino]phenyl]butyrate]|LEO-1031|Leo 1031|Sterecyt|Stereocyt
C769	Prednisolone	Therapeutic_Glucocorticoid	Prednisolone|(11beta)-11,17,21-Trihydroxypregna-1,4-diene-3,20-dione|.delta.1-Hydrocortisone|1,2-Dehydrohydrocortisone|Adnisolone|Aprednislon|Capsoid|Cortalone|Cortisolone|Dacortin H|Decaprednil|Decortin H|Delta(1)Hydrocortisone|Delta- Cortef|Delta-Cortef|Delta-Diona|Delta-F|Delta-Phoricol|Delta1-dehydro-hydrocortisone|Deltacortril|Deltahydrocortisone|Deltasolone|Deltidrosol|Dhasolone|Di-Adreson-F|Dontisolon D|Estilsona|Fisopred|Frisolona|Gupisone|Hostacortin H|Hydeltra|Hydeltrasol|Klismacort|Kuhlprednon|Lenisolone|Lepi-Cortinolo|Linola-H N|Linola-H-Fett N|Longiprednil|Metacortandralone|Meti Derm|Meticortelone|Opredsone|PREDNISOLONE|Panafcortelone|Precortisyl|Pred-Clysma|Predeltilone|Predni-Coelin|Predni-Helvacort|Prednicortelone|Prednisolonum|Prelone|Prenilone|Sterane|prednisolone	A synthetic corticosteroid used in the treatment of blood cell cancers (leukemias) and lymph system cancers (lymphomas).
C770	Prednisone	Therapeutic_Glucocorticoid	Prednisone|.delta.1-Cortisone|1, 2-Dehydrocortisone|17,21-Dihydroxypregna-1,4-diene-3,11,20-trione|1;2-Dehydrocortisone|Adasone|Cortancyl|Dacortin|DeCortin|Decortisyl|Decorton|Delta(1)-Cortisone|Delta-Dome|Deltacortene|Deltacortisone|Deltadehydrocortisone|Deltasone|Deltison|Deltra|Econosone|Liquid Pred|Lisacort|Meprosona-F|Metacortandracin|Meticorten|Ofisolona|Orasone|PRED|PREDNISONE|Panafcort|Panasol-S|Paracort|Predeltin|Predicor|Predicorten|Prednicen-M|Prednicort|Prednidib|Prednilonga|Predniment|Prednisonum|Prednitone|Promifen|SK-Prednisone|Servisone|Sk-Prednisone|Sterapred|prednisone	A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.  After cell surface receptor attachment and cell entry, prednisone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production.  This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI04)
C771	Primaquine	Antimalarial_Agent	Primaquine Phosphate|PRIMAQUINE PHOSPHATE|Primaquine	A synthetic, 8-aminoquinoline derivative with antimalarial properties.  Although its mechanism of action is unclear, primaquine bind to and alter the properties of protozoal DNA.  This agent eliminates tissue (exo-erythrocytic) malarial infection, preventing the development of the erythrocytic forms of the parasite which are responsible for relapses in Plasmodium vivax and ovale malaria.  Primaquine is active against late hepatic stages (hypnozoites, schizonts). (NCI04)
C772	Probenecid	Nephroprotective_Agent	Probenecid|Benemid|PROBENECID|SK-Probenecid|probenecid	A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called antibiotic therapy adjuncts.
C773	Procarbazine	Triazene_Compound	Procarbazine Hydrochloride|Benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI)|Benzethyzin|Ibenzmethyzin|Ibenzmethyzine hydrochloride|MIH hydrochloride|Matulane|N-(1-methylethyl)-4-[(2-methylhydrazino)methyl]benzamide|N-4-isopropylcarbamoylbenzyl-N'-methylhydrazine|N-Methylhydrazine|N-isopropyl-alpha-(2-methylhydrazino)-p-toluamide|NCI-C01810|Natulan|Natulanar|Natunalar|PCB|PCB Hydrochloride|PCB hydrochloride|PCZ|PROCARBAZINE HYDROCHLORIDE|Procarbazin|Procarbazine|Ro 4 6467/1|Ro 4-6467/1|benzamide, N-(1-methylethyl)-4-[(2-methylhydrazino) methyl]-, monohydrochloride (9CI)|p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide|p-(N'-methylhydrazinomethyl)-N-isopropylbenzamide hydrochloride|p-Toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI)|p-toluamide, N-isopropyl-.alpha.-(2-methylhydrazino)-, monohydrochloride (8CI)|procarbazine	A methylhydrazine derivative with antineoplastic and mutagenic activities. Although the exact mode of cytotoxicity has not been elucidated, procarbazine, after metabolic activation, appears to inhibit the trans-methylation of methionine into transfer RNA (t-RNA), thereby preventing protein synthesis and consequently DNA and RNA synthesis. This agent may also undergo auto-oxidation, resulting in the formation of cytotoxic free radicals which damage DNA through an alkylation reaction. (NCI04)
C774	Prochlorperazine	Phenothiazine	Prochlorperazine|2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)-phenothiazine|PROCHLORPERAZINE|RP 6140|SKF-4657|prochlorperazine	(pro-klor-PAIR-a-zeen) A drug that prevents or reduces nausea and vomiting.  It belongs to the family of drugs called antiemetics.
C775	Prochlorperazine_Maleate	Prochlorperazine	Prochlorperazine Maleate|Compazine|PROCHLORPERAZINE MALEATE|Prochlorperazine Dimaleate	The maleate salt form of prochlorperazine.  As a synthetic propylpiperazine derivative of phenothiazine, prochlorperazine has antiemetic, antipsychotic, antihistaminic, and anticholinergic activities.  Prochlorperazine antagonizes the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain and may prevent chemotherapy-induced emesis. (NCI)
C776	Therapeutic_Progestin	Therapeutic_Steroid_Hormone	Therapeutic Progestin|Progesterone Agents|Progestogens
C777	Therapeutic_Progesterone	Multidrug_Resistance_Modulator|Therapeutic_Progestin	Therapeutic Progesterone|Corlutina|Corluvite|Corpus luteum hormone|Cyclogest|Delta4-pregnene-3,20-dione|Gestiron|Gestone|Lipo-Lutin|Luteohormone|Lutocyclin|Lutocylin M|Lutogyl|Lutromone|PROGESTERONE|Progestasert|Progesterone|Progestin|Progestogel|Progestol|Progeston|Prolidon|Proluton|Syngesterone|Utrogestan	A synthetic form of the endogenous hormone progesterone.  Progesterone binds to the progesterone receptor, resulting in dissociation of heat shock proteins, receptor phosphorylation, and transcription activation through direct or indirect interaction with transcription factors.  This agent exerts inhibitory effects on estrogens by decreasing the number of estrogen receptors and increasing its metabolism to inactive metabolites.  Progesterone induces secretory changes in the endometrium, decreases uterine contractility during pregnancy, and maintains pregnancy. (NCI04)
C778	Prolactin	Pituitary_Hormone	Prolactin|PRL	Human prolactin (227 aa, 26 kDa precursor) is encoded by the human prolactin (PIT1) gene. This secreted lactogenic glycoprotein is expressed in both anterior pituitary lactotropes and the decidual endometrium. It acts primarily on the mammary gland and, in synergy with estrogen, induces progesterone release by corpus luteum cells to render the uterine mucosa suitable for implantation.
C779	Promethazine	Phenothiazine	Promethazine
C780	Therapeutic_Corynebacterium_Parvum	Vaccine_Adjuvant	Therapeutic Corynebacterium Parvum|C. parvum|CPAR|Coparvax|Corynebacterium parvum, Burroughs|Corynebacterium parvum, Merieux|Propionibacterium acnes	A heat-inactivated preparation of Corynebacterium parvum with immunoadjuvant properties. Therapeutic Corynebacterium parvum may stimulate host antitumor immune responses when added to cancer vaccines. (NCI04)
C781	Propylthiouracil	Antithyroid_Agent	Propylthiouracil|6-Propyl-2-Thiouracil|6-Propyl-2-thiouracil|PROPYLTHIOURACIL
C782	Prostaglandin	Eicosanoid	Prostaglandin
C783	Protease_Inhibitor	Antiviral_Agent|Enzyme_Inhibitor	Protease Inhibitor|Protease Inhibitors|protease inhibitors	Compounds that interfere with the ability of certain enzymes to break down proteins.  Some protease inhibitors can keep a virus from making copies of itself (e.g., AIDS virus protease inhibitors), and some can prevent cancer cells from spreading.
C784	Protein_Synthesis_Inhibitor	Pharmacologic_Substance	Protein Synthesis Inhibitor
C785	Protoporphyrin	Photosensitizing_Agent|Porphyrin	Protoporphyrin|3,7,12,17-Tetramethyl-8,13-divinyl-2,18-porphinedipropionic Acid
C786	Purine	Heterocyclic_Compound	Purine	bicyclic ring structure consisting of fused imidazole and pyrimidine rings, with nitrogen atoms at the 1,3,7, and 9 positions; the basic structure of adenine, guanine, and other biologically important bases.
C787	Puromycin	Miscellaneous_Antineoplastic_Antibiotic|Protein_Synthesis_Inhibitor	Puromycin|Adenosine, 3'-((2-amino-3-(4-methoxyphenyl)-1-oxopropyl)amino)-3'-deoxy-N,N-dimethyl-, (S)-|Adenosine, 3'-(alpha-amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyl-, L-|CL 16536|L-3'-(alpha-Amino-p-methoxyhydrocinnamamido)-3'-deoxy-N,N-dimethyladenosine|P-638|Puromicina|Puromycine|Puromycinum|Stillomycin|Stylomycin	An aminoglycoside antibiotic isolated from the bacterium Streptomyces alboniger.  Acting as an analog of the 3' terminal end of aminoacyl-tRNA, puromycin incorporates itself into a growing polypeptide chain and causes its premature termination, thereby inhibiting protein synthesis.  This agent has antimicrobial, antitrypanosomal, and antineoplastic properties; its is used as an antibiotic in cell culture. (NCI04)
C788	Pyrimethamine	Antimalarial_Agent|Folate_Antagonist	Pyrimethamine|Daraprim|PYRIMETHAMINE	A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties.  Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR).  DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins.  This agent is often used in combination with other antimalarials for the treatment of uncomplicated falciparum malaria. (NCI04)
C789	Pyrimidine	Heterocyclic_Compound	Pyrimidine	One of two classes of heterocyclic nitrogenous bases found in the nucleic acids DNA and RNA: in DNA the pyrimidines are cytosine and thymine, in RNA uracil replaces thymine.
C790	Pyrimidine_Dimer	DNA_Adduct	Pyrimidine Dimer	covalently linked adjacent pyrimidine bases (usually thymidine) on a strand of DNA produced by UV light or other radiation; the mutation blocks both transcription and replication until excised and repaired.
C791	Crystalline_Silica_Quartz	Mineral	Crystalline Silica Quartz
C792	Quercetin	Bioflavonoid	Quercetin|2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-1-benzopyran-4-one|3,3',4',5,7-Pentahydroxyflavone|C.I. Natural Yellow 10|Quercetin Dihydrate	A flavonol from azaleas being evaluated for its chemopreventive qualities. (Chemical and Physical Carcinogenesis Branch, DCB homepage)
C793	Quinidine	Multidrug_Resistance_Modulator	Quinidine|QUINIDINE
C794	Quinine	Antimalarial_Agent|Multidrug_Resistance_Modulator	Quinine|(-)-Quinine|QUININE	A quinidine alkaloid isolated from the bark of the cinchona tree. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution.  This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
C795	Quinolone_Antibiotic	Antibiotic	Quinolone Antibiotic	The basic structure of quinolone is nalidixic acid that has limited therapeutic value.  However, the development of fluorinated quinolones led to new derivative compounds with broad antibacterial activity.  Both DNA gyrase and topoisomerase IV are targets of quinolones.
C796	Quinone_Compound	Organic_Chemical	Quinone Compound|Quinone
C797	Radioprotective_Agent	Protective_Agent	Radioprotective Agent|Radiation Effect Modifiers
C798	Radiosensitizing_Agent	Adjuvant	Radiosensitizing Agent|Radiation Sensitizers|Radiation-Sensitizing Agents|Radiation-Sensitizing Drugs|Radiosensitizers|Radiosensitizing Drugs|radiosensitizers	Drugs that make tumor cells more sensitive to radiation therapy.
C799	Radioisotope	Isotope	Radioisotope|Radionuclide|radioisotope	An unstable element that releases radiation as it breaks down. Radioisotopes can be used in imaging tests or as a treatment for cancer.
C800	Radon	Radioactive_Element	Radon|radon	(RAY-don) A radioactive gas that is released by uranium, a substance found in soil and rock. Breathing in too much radon can damage lung cells and lead to lung cancer.
C801	Razoxane	Antineoplastic_Agent|Chelating_Agent	Razoxane|ICI 59118|ICRF 159|ICRF-159|Razoxin	A bis-dioxopiperazine and a derivative of the chelating agent EDTA with antineoplastic activity. Razoxane inhibits the enzyme topoisomerase II without inducing DNA strand breaks, thereby inhibiting DNA synthesis and inducing cytotoxicity. Although its mechanism is unknown, this agent exhibits anti-angiogenic activity. (NCI04)
C802	Reagent	Drugs_and_Chemicals_Functional_Classification	Reagent	A general purpose reagent is a chemical reagent that has general laboratory application, that is used to collect, prepare, and examine specimens from the human body for diagnostic histopathology, cytology, and hematology, and that is not labeled or otherwise intended for a specific diagnostic application. General purpose reagents include cytological preservatives, decalcifying reagents, fixatives and adhesives, tissue processing reagents, isotonic solutions, and pH buffers. (SPN02)
C803	Reserpine	Multidrug_Resistance_Modulator	Reserpine|(3beta,16beta,17alpha,18beta,20alpha)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic Acid Methyl Ester|RESERPINE
C804	Retinoic_Acid_Agent	Differentiation_Inducer	Retinoic Acid Agent|Retinoic Acid and Derivatives|Retinoic Acids|Retinoid|Retinoids|retinoid	A group of agents that includes retinol (Vitamin A) and related compounds with potential antineoplastic and/or chemopreventive activities.  A retinoic acid agent binds to and/or activates specific nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs), thereby modulating transcription of genes responsible for cell differentiation and proliferation.  A retinoic acid agent may exhibit immunomodulatory and anti-inflammatory properties and may inhibit ornithine decarboxylase, resulting in a decrease in polyamine synthesis and keratinization. (NCI04)
C805	Rheumatoid_Factor	Pathologic_Ab-Ig_Protein	Rheumatoid Factor	Antibodies in the serum of individuals with rheumatoid arthritis that react with antigenic determinants or immunoglobulins that enhance agglutination of suspended particles coated with pooled human gamma -globulin. Rheumatoid factors also occur in other autoimmune and certain infectious diseases.
C806	Rhodamine	Fluorochrome	Rhodamine
C807	Ribavirin	Miscellaneous_Antiviral_Agent	Ribavirin|1-.beta.-D-Ribofuranosyl-1H-1,2, 4-triazole-3-carboxamide|1-Beta-D-ribofuranosyl-1,2,4-triazolo-3-carboxamide|1-Beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide|ICN 1229|ICN-1229|RIBAVIRIN|RTCA|Rebetol|Viramide|Virazid|Virazole|ribavirin	A drug used to treat respiratory syncytial virus (RSV) infection in the lungs.
C808	Riboflavin	B_Vitamin	Riboflavin|6,7-Dimethyl-9-D-ribitylisoalloxazine|Lactoflavin|RIBOFLAVIN|Riboflavine|Vitamin B2	7,8-dimethyl-10-ribitylisoalloxazine: a heat-stable factor of the water-soluble vitamin B complex whose isoalloxazine nucleotides are coenzymes of the flavodehydrogenases. Its principal forms in tissues and cells are as FMN and FAD.
C809	Ricin	Nutritional_Toxin|Protein_Synthesis_Inhibitor	Ricin|RICIN|Ricinus Communis Agglutinin II	A highly toxic protein phytotoxin lectin and hemagglutin from the seeds of Ricinus communis, the castor oil plant.  It agglutinates cells, is proteolytic, and causes lethal inflammation and hemorrhage if taken internally.  It has N-glycosidase activity that cleaves 28S rRNA, halting protein synthesis; extreme cytotoxicity makes ricin an attractive candidate for artificial fusion with binding proteins to create cell-type-specific toxins.
C810	Ricin_A_Chain	Ricin	Ricin A Chain	One of the two glycoprotein disulfide-linked chains of Ricinus Communis Agglutin II that causes protein synthesis inhibition and cell death. (NCI)
C811	Rifampin	Antitubercular_Agent|RNA_Polymerase_Inhibitor	Rifampin|L-5103|Rifadin|Rimactane
C812	Ribonucleic_Acid	Nucleic_Acids	Ribonucleic Acid|RNA|Ribonucleic acid|ribonucleic acid	A nucleic acid molecule similar to DNA but containing ribose rather than deoxyribose. RNA is formed upon a DNA template. There are several classes of RNA molecules. They play crucial roles in protein synthesis and other cell activities. (MedicineNet.com)
C813	Messenger_RNA	Gene_Product	Messenger RNA|mRNA	Messenger RNA.  A class of RNA molecules that contain protein-coding information in their nucleotide sequence and can be translated into the amino acid sequence of a protein. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
C814	Ribosomal_RNA	Functional_RNA	Ribosomal RNA|rRNA	Class of RNA molecules that do not contain protein-coding sequence information.  These RNAs constitute the majority of the cellular RNA (~ 80%); they associate with multiple proteins into a macromolecular complex termed ribosomes, in which mRNA-directed protein synthesis occurs.  The three eukaryotic rRNAs are named 28S, 18S, and 5S rRNA.
C815	Small_Nuclear_RNA	Small_RNA	Small Nuclear RNA|snRNA|uRNA	Small nuclear RNA.  A class of abundant small nuclear RNAs involved in RNA processing (splicing, 3' end maturation).  These snRNAs associate with specific proteins to form the small nuclear ribonucleoprotein particles (snRNP) directly involved in RNA processing.  Seven known snRNAs have been termed U1 through U7 snRNA.
C816	Transfer_RNA	Functional_RNA	Transfer RNA|Triplet Codon-Amino Acid Adaptor|tRNA	A class of RNA having structures with triplet nucleotide sequences that are complementary to the triplet nucleotide coding sequences of mRNA. The role of tRNAs in protein synthesis is to bond with amino acids and transfer them to the ribosomes, where proteins are assembled according to the genetic code carried by mRNA. (BioTech Life Science Dictionary)
C817	Ceftriaxone	Cephalosporin_Antibiotic	Ceftriaxone Sodium|CEFTRIAXONE SODIUM|Cefriaxone Sodium|Ceftriaxone|Rocephin|ceftriaxone	An antibiotic drug used to treat infection. It belongs to the family of drugs called cephalosporin antibiotics.
C818	Roxithromycin	Macrolide_Antibiotic	Roxithromycin|(9E)-Erythromycin, 9-[O-[(2-methoxyethoxy)methyl]oxime]|9-(2',5'-Dioxahexyloxyimino)erythromycin|RU 28965|RU 965|Roxitromycine|Rulide
C819	Rutin	Bioflavonoid	Rutin|3-[[6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one|Quercetin 3-Rutinoside|RUTIN
C820	Safflower_Oil	Food_Oil	Safflower Oil|Oil, Safflower
C821	Saline	Drug_Vehicle	Saline|saline	A solution of salt and water.
C822	Salt	Inorganic_Chemical	Salt
C823	Saponin	Antineoplastic_Plant_Product|Glycoside_Compound	Saponin|SAPONIN|Steroid Saponins|saponin	A substance found in soybeans and many other plants. Saponins may help lower cholesterol and may have anticancer effects.
C824	Sizofiran	Chemo_Immunostimulant_Adjuvant|Immunostimulant	Sizofiran
C825	Selenium	Antioxidant|Element_or_Isotope|Radioprotective_Agent	Selenium|selenium	An element with atomic symbol Se, atomic number 34, and atomic weight 78.96.
C826	Selenomethionine	Antioxidant	Selenomethionine|Butanoic acid, 2-amino-4-(methylseleno)-	A substance containing selenium, a trace element, in place of the sulfur in methionine, an amino acid, used as a nutritional supplement for selenium.(NCI)
C827	Semustine	Nitrosourea_Compound	Semustine|1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea|1-(2-Chloroethyl)-3-(Trans-4-Methylcyclohexane)-1-Nitrosourea|1-(2-Chloroethyl)-3-(trans-4-methylcyclohexane)-1-nitrosourea|1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea|Lomustine, Methyl|Lomustine, methyl|MCCNU|MeCCNU|Methyl CCNU|Methyl Lomustine|Urea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-, trans- (8CI)|Urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI)|methyl-CCNU|semustine|trans-Methyl-CCNU|urea, 1-(2-chloroethyl)-3-(4-methylcyclohexyl)-1-nitroso-, trans- (8CI)|urea, N-(2-chloroethyl)-N'-(4-methylcyclohexyl)-N-nitroso-, trans- (9CI)	A methylated derivative of carmustine with antineoplastic activity. As an alkylating agent, semustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)
C828	Serotonin	Neurotransmitter	Serotonin|5-HT|5-Hydroxytryptamine|SEROTONIN
C829	Tobacco_Smoke	Pollutant	Tobacco Smoke|SMK|Smoke	Smoke from burning tobacco (cigarettes, cigars, or pipes) and exhaled by a smoker.  Tobacco smoke contains nicotine, a stimulant, and other biologically active chemicals having carcinogenic properties.(NCI)
C830	Sodium	Electrolytes|Element_or_Isotope	Sodium|NA|Sodium (NOS)|sodium	A mineral needed by the body to keep body fluids in balance.  Sodium is found in table salt and in many processed foods.  Too much sodium can cause the body to retain water.
C831	Etidronate_Disodium	Etidronate	Etidronate Disodium|Calcimux|Didronel|Diphos|Disodium Dihydrogen (1-hydroxyethylidene)bis(phosphonate)|ETIDRONATE DISODIUM|Etidron	A synthetic therapeutic diphosphonate analogue of endogenous pyrophosphate. As a member of the family of drugs known as bisphosphonates, etidronate disodium differs from endogenous pyrophosphate in its resistance to enzymatic hydrolysis.  This agent adsorbs to hydroxyapatite cells and reduces the number of osteoclasts, thereby inhibiting abnormal bone resorption.  Etidronate may also directly stimulate bone formation by osteoblasts. (NCI04)
C832	Sodium_Fluoride	Nutritional_Supplement	Sodium Fluoride|Fluoride, sodium|SODIUM FLUORIDE|Sodium Fluoride (NaF)|Sodium fluoride	An inorganic salt of fluoride used topically or in municipal water fluoridation systems to prevent dental caries.  Fluoride appears to bind to calcium ions in the hydroxyapatite of surface tooth enamel, preventing corrosion of tooth enamel by acids. This agent may also inhibit acid production by commensal oral bacteria. (NCI04)
C833	Heparin_Sodium	Heparin	Heparin Sodium|Hep-Lock|Heparin sodium|Lipo-Hepin|Sodium heparin	The sodium salt form of heparin.  As a glycosaminoglycan anticoagulant, heparin sodium binds to antithrombin III to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin. (NCI)
C834	Sodium_Salicylate	Nonsteroidal_Antiinflammatory_Drug	Sodium Salicylate|Benzoic acid, 2-hydroxy-, monosodium salt|Disalcid|Salicylate, sodium|Sodium salicylate|sodium salicylate	A drug that belongs to the family of drugs called nonsteroidal anti-inflammatory drugs.  Sodium salicylate may be tolerated by people who are sensitive to aspirin.
C835	Therapeutic_Insulin-Like_Growth_Factor	Therapeutic_Growth_Factor	Recombinant Insulin-Like Growth Factor|Rh IGF|Rh Insulin Like Growth Factor|Somatomedin	A recombinant human antiapoptotic growth factor.  Recombinant insulin-like growth factor (IGF) binds to and activates the insulin and IGF receptors; activation of these receptors initiates intracellular phosphorylation events and the activation of several signaling pathways, thereby promoting cellular proliferation and inhibiting apoptosis. High levels of circulating endogenous insulin-like growth factor may indicate a poor prognosis in some cancers. (NCI04)
C836	Growth_Hormone_Release_Inhibiting_Factor	Hormone_Antagonist	Growth Hormone Release Inhibiting Factor|GH-RIF|GHRIH|Growth Hormone Inhibiting Factors|Panhibin|SRIF|Somatotropin Release Inhibiting Factor|Somatotropin Release Inhibiting Factors	A class of synthetic agents which inhibit the secretion or release of a particular growth hormone.  These agents may counteract the action of growth hormone release factors, which are secreted by the hypothalamus, gut, pancreas and gonads and stimulate pituitary growth hormone synthesis and secretion. (NCI04)
C837	Therapeutic_Growth_Hormone	Pituitary_Agent	Recombinant Growth Hormone|Recombinant Human Growth Hormone|Somatotropic Hormone|Somatotropin|Therapeutic GH|rhGH	A synthetically-derived form of endogenous growth hormone (GH), a polypeptide produced by the pituitary gland.  The synthetic therapeutic form is usually derived from recombinant sources. GH exhibits growth-promoting effects and metabolic effects on carbohydrate, fat, protein and bone metabolism.  GH stimulates protein synthesis and the uptake of amino acids into the cells, and induces lipolysis in adipose tissues.  GH secretion increases with sexual maturation and then it declines steadily. (NCI04)
C838	Soybean_Oil	Food_Oil	Soybean Oil|Soybean oil
C839	Spiramycin	Macrolide_Antibiotic	Spiramycin
C840	Spironolactone	Diuretic	Spironolactone|17-Hydroxy-7alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic Acid, gamma Lactone, Acetate|Aldactone|SC 9420|SPIRONOLACTONE	A synthetic 17-spironolactone corticosteroid with potassium-sparing diuretic, antihypertensive, and antiandrogen activities. Spironolactone competitively inhibits adrenocortical hormone aldosterone activity in the distal renal tubules, myocardium, and vasculature.  This agent may inhibit the pathophysiologic effects of aldosterone produced in excess by various types of malignant and benign tumors. (NCI04)
C841	Stain	Conceptual_Entities	Stain	A dye or other coloring material that is used in microscopy to make structures visible.
C842	Stanozolol	Anabolic_Steroid|Therapeutic_Androgen	Stanozolol|WIN 14833|Winstrol
C843	Steroid_Compound	Lipid	Steroid Compound|Steroid|Steroids|steroid	(STAIR-oyd) A type of drug used to relieve swelling and inflammation.
C844	Streptonigrin	Miscellaneous_Antineoplastic_Antibiotic	Streptonigrin|5-Amino-6-(7-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methyl-2-pyridinecarboxylic Acid|5-Amino-6-(70-amino-5,8-dihydro-6-methoxy-5,8-dioxo-2-quinolyl)-4-(2-hydroxy-3,4-dimethoxyphenyl)-3-methylpicolinic Acid|BA-163|Bruneomycin|NSC 45383|NSC-45383|PC-501|Rufocromomycin|STREPTONIGRIN	An aminoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces flocculus.  Streptonigrin complexes with DNA and topoisomerase II, resulting in DNA cleavage and inhibition of DNA replication and RNA synthesis.  This agent also acts as a reverse transcriptase inhibitor and causes free radical-mediated cellular damage. (NCI04)
C845	Streptozocin	Miscellaneous_Antineoplastic_Antibiotic|Nitrosourea_Compound	Streptozocin|2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose|2-deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose|2-deoxy-2-[[(methylnitrosamino)-carbonyl]amino]-D-glucopyranose|NSC 85998|STZ|Streptozotocin|U 9889|U-9889|Zanosar|streptozocin	A methylnitrosourea antineoplastic antibiotic isolated from the bacterium Streptomyces achromogenes.  Streptozocin alkylates DNA, forming inter-strand DNA cross-links and inhibiting DNA synthesis.  Due to its glucose moiety, this agent is readily taken up by pancreatic beta cells, inducing diabetes mellitus at high concentrations.  Unlike other nitrosoureas, streptozocin causes little myelosuppression. (NCI04)
C846	Strontium	Metals	Strontium|Sr|strontium	A metal often used in a radioactive form for imaging tests or as a treatment for cancer.
C847	Substance-P	Neuropeptide	Substance P	An eleven-amino acid neurotransmitter that appears in both the central and peripheral nervous systems. It is involved in transmission of pain, causes rapid contractions of the gastrointestinal smooth muscle, and modulates inflammatory and immune responses.
C848	Sucralfate	Cytoprotective_Agent|Radioprotective_Agent	Sucralfate|Carafate|sucralfate	A drug used to treat ulcers. It adheres to proteins at the ulcer site and forms a protective coating over the ulcer. Sucralfate is also used to treat mucositis.
C849	Sulfone_Anti-Infective_Agent	Anti-Infective_Agent	Sulfone Anti-Infective Agent|Sulfone|Sulfones	any compound of the type R-SO2-R.
C850	Sulindac	Cyclooxygenase_Inhibitor	Sulindac|(Z)-5-fluoro-2-methyl-1-[[4-(methylsulfinyl)phenyl]methylene]-1H-indene-3-acetic acid|Aflodac|Algocetil|Apo-Sulin|Arthrocine|Artribid|Citireuma|Clinoril|Clisundac|Imbaral|MK-231|Novo-Sundac|Reumofil|Reumyl|SULINDAC|Sudac|Sulindac Sulfoxide|Sulinol|Sulreuma|cis-5-fluoro-2-methyl-1-[p-(methylsulfinyl)benzylidene]indene-3-acetic acid|sulindac	A nonsteroidal anti-inflammatory drug (NSAID) that is being studied as a treatment for cancer.
C851	Sunscreen	Chemopreventive_Agent	Sunscreen|Sunblock|sunscreen	A substance that helps protect the skin from the sun's harmful rays. Sunscreens reflect, absorb, and scatter both ultraviolet A and B radiation to provide protection against both types of radiation. Using lotions, creams, or gels that contain sunscreens can help protect the skin from premature aging and damage that may lead to skin cancer.
C852	Superoxide	Oxygen_Radicals	Superoxide
C853	Suramin	Matrix_Metalloproteinase_Inhibitor	Suramin|suramin	A drug used to treat bacterial and parasitic infections. It is also being studied in the treatment of cancer.
C854	Talc	Drug_Vehicle	Talc|Sclerosol Intrapleural Aerosol|Steritalc	Finely-powdered native hydrous magnesium silicate.  When administered into the pleural space, talc initiates an inflammatory reaction, resulting in adhesion of the visceral pleura to the parietal pleura and fibrosis, thereby effectively closing the pleural space and preventing further accumulation of fluid. This agent exhibits no intrinsic antineoplastic activity. (NCI04)
C855	Tamoxifen	DNA_Adduct_Forming_Agent|Endothelial_Cell_Inhibitor|Protein_Kinase_C_Inhibitor|Selective_Estrogen_Receptor_Modulator	Tamoxifen Citrate|(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine|(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate (1:1)|(Z)-2-[4-(1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine citrate|1-p-beta-dimethylamino-ethoxyphenyl-trans-1,2-diphenylbut-1-ene|Apo-Tamox|Clonoxifen|Dignotamoxi|Ebefen|Emblon|Estroxyn|Fentamox|Gen-Tamoxifen|Genox|ICI 46,474|ICI-46474|Jenoxifen|Kessar|Ledertam|Lesporene|Nolgen|Noltam|Nolvadex|Nolvadex-D|Nourytam|Novo-Tamoxifen|Novofen|Noxitem|Oestrifen|Oncotam|PMS-Tamoxifen|Soltamox|TAM|TAMOXIFEN CITRATE|Tamax|Tamaxin|Tamifen|Tamizam|Tamofen|Tamoxasta|Tamoxifen|Tamoxifen citrate|Tamoxifeni Citras|Zemide|tamoxifen	An anticancer drug that belongs to the family of drugs called antiestrogens. Tamoxifen blocks the effects of the hormone estrogen in the body. It is used to prevent or delay the return of breast cancer or to control its spread.
C856	Tc_99m_Sulfur_Colloid	Radioconjugate	Technetium Tc 99m Sulfur Colloid|Tc 99m Sulfur Colloid|technetium Tc 99m sulfur colloid	A gamma-emitting colloid used in scintillation scanning of the reticuloendothelial system (RES). After intravenous administration, technetium Tc 99m sulfur colloid is phagocytized by the reticuloendothelial system and concentrated in the liver, spleen, and bone marrow; detection/localization of phagocytized gamma ray-emitting colloid is performed with a gamma-ray scintillation camera. Scintillation scanning using technetium Tc 99m colloid sulfur helps determine the distribution and function of the RES and the extent to which tumor involves the RES. The RES includes cells types that can phagocytize and sequester inert particles and vital dyes; RES cell types include macrophages or macrophage precursors, specialized endothelial cells lining the sinusoids of the liver, spleen, and bone marrow, and reticular cells of lymphatic tissue and of bone marrow.
C857	Teniposide	Epipodophyllotoxin_Compound	Teniposide|4'-Demethylepipodophyllotoxin 9-(4,6-O-2-Thenylidene-beta-D-glucopyranoside)|4'-Demethylepipodophyllotoxin-beta-D-thenylidine Glucoside|EPT|PTG|TENIPOSIDE|Teniposide (VM-26)|Thenvlidene-Lignan-P|Thenylidene-Lignan-P|VM 26|VM-26|Vehem|Vumon|[5R-[5Alpha,5a beta,8a alpha, 9beta(R*)]]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-(2-thienylmethylene)-beta-D-glucopyranosyl]oxy]furo[3',4':6,7]-naphtho[2,3-d]-1,3-dioxol-6(5aH)-one|teniposide	A semisynthetic derivative of podophyllotoxin with antineoplastic activity. Teniposide forms a ternary complex with the enzyme topoisomerase II and DNA, resulting in dose-dependent single- and double-stranded breaks in DNA, DNA: protein cross-links, inhibition of DNA strand religation, and cytotoxicity. This agent acts in the late S or early G phase of the cell cycle. (NCI04)
C858	Tenuazonic_Acid	Antifungal_Agent	Tenuazonic Acid|Tenuazonic acid|[S-(R*,R*)]-3-Acetyl-1,5-dihydro-4-hydroxy-5-(1-methylpropyl)-2H-pyrrol-2-one
C859	Teratogen	Chemical_Modifier	Teratogen
C860	Terpene_Compound	Hydrocarbon|Lipid	Terpene Compound|Terpenes	The class of compound known as terpenes comprise of essential oils, flavours and fragrances. The extraction and synthesis of compounds such as these is the basis for the perfumery industry. They find a variety of uses in the food and pharmaceutical industry as flavour and odour improvers
C861	Testolactone_Therapeutic	Retired_Concepts	Testolactone (Therapeutic)|1,2,3,4,4a,4b,7,9,10,10a-Decahydro-2-hydroxy-2,4b-dimethyl-7-oxo-1-phenanthrenepropionic Acid Delta-lactone|1-Dehydrotestololactone|13-Hydroxy-3-0x0-13,17-secoandrosta-1,4-dien-17-oic Acid Delta-lactone|17Alpha-oxo-D-homo-1,4-androstadiene-3,17-dione|D-Homo-17a-oxaandrosta-1,4-diene-3,17-dione|Delta 1-Testolactone|Delta-1-testololactone|Fludestrin|SQ-9538|Teslac
C862	Therapeutic_Testosterone	Anabolic_Steroid|Therapeutic_Androgen	Therapeutic Testosterone|(17Beta)-17-hydroxyandrost-4-en-3-one|Delta4-Androsten-17beta-ol-3-one|Mertestate|TESTOSTERONE|Testoderm|Testolin|Testosterone|Testostroval|Testostroval-PA|Testro AQ|Trans-Testosterone|Virosterone	A synthetic form of the endogenous androgenic steroid testosterone.  Due to rapid metabolism by the liver, therapeutic testosterone is generally administered as an ester derivative.  This agent and its derivatives promote the maintenance of male sex characteristics and are indicated for testosterone replacement in hypogonadal males, delayed puberty, and metastatic mammary cancer. (NCI04)
C863	Testosterone_Propionate	Therapeutic_Testosterone	Testosterone Propionate|(17beta)-17-(1-Oxopropoxy)androst-4-en-3-one|Anertan|Enarmon|Neo-Hombreol|Orchisterone-P|Oreton|Perandren (Amp.)|Synerone|TESTOSTERONE PROPIONATE|Testex|Testosterone propionate|Testosterone-17beta-Propionate|Testoviron (amps)|Virormone|neo-Hombreol	A short acting oil-based injectable formulation of testosterone.  Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels.  In addition, this agent promotes the maintenance of male sex characteristics and is indicated for testosterone replacement in hypogonadal males. (NCI04)
C864	Tetrachlorodibenzodioxin	Dioxin_Compound|Organo-halide_Carcinogen	Tetrachlorodibenzodioxin|2,3,7,8-Tetrachlorodibenzo[b,e][1,4]dioxin|TCDD	2,3,7,8-Tetrachlorodibenzo-p-dioxin which is often referred to simply as dioxin and is the reference for a number of compounds which are similar structurally and have dioxin-like toxicity. A substance extremely toxic to mammals, with a wide variation in sensitivity among species. Longer-term exposure of test mammals to lesser amounts can affect reproduction, cause birth defects, damage the liver and suppress the immune system. Several studies suggest that exposure to TCDD increases the risk of several types of cancer in people. Animal studies have also shown an increased risk of cancer from exposure to TCDD. The WHO and the USA DHHS have determined that TCDD is a human carcinogen. (NCI)
C865	Tetracycline	Tetracycline_Antibiotic	Tetracycline|4-(Dimethylamino)-1,4,4A,5,5A,6,11,12A-Octahydro-3,6,10,12,12A-Pentahydroxy-6-Methyl-1,11-Dioxo-2-Naphthacenecarboxamide|TCN|TETRACYCLINE|tetracycline	A broad-spectrum naphthacene antibiotic produced semisynthetically from chlortetracycline, an antibiotic isolated from the bacterium Streptomyces aureofaciens. In bacteria, tetracycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. (NCI05)
C866	Tetradecanoylphorbol_Acetate	Differentiation_Inhibitor	Tetradecanoylphorbol Acetate|12-O-tetradecanoylphorbol-13-acetate|Lonomycin|PMA|PMAS|Phorbol Myristate Acetate|TPA	A drug that is being studied as a treatment for hematologic cancer.
C867	Dronabinol	Antiemetic_Agent|Nonnarcotic_Analgesic	Dronabinol|(-)-.DELTA.9-Tetrahydrocannabinol|Abbott 40566|Cannabinol|DRONABINOL|Delta 9-Tetrahydrocannabinol|Delta-9-Tetrahydrocannabinol (THC)|Marinol|SP 104|SP-104|THC|Tetrahydrocannabinol|dronabinol	A synthetic form of delta-9-tetrahydrocannabinol, a psychoactive substance found in Cannabis sativa.  Dronabinol acts directly on the appetite and vomiting control centers in the brain to stimulate appetite and prevent emesis. (NCI04)
C868	Tetrahydrouridine	Cytidine_Deaminase_Inhibitor|Multidrug_Resistance_Modulator	Tetrahydrouridine|2(1H)-pyrimidinone, tetrahydro-4-hydroxy-1-beta-D-ribofuranosyl-|THU	A synthetic pyrimidine nucleoside analogue with biomodulating activity. Tetrahydrouridine increases the efficacy of the radiosensitizer cytochlor (5-chloro-2'-deoxycytidine) by inhibiting the enzyme deoxycytidine monophosphate (dCMP) deaminase and preventing the premature deamination of the cytochlor metabolite 5-chloro-2'-deoxycytidine monophosphate (CldCMP) to 5-chloro-2'-deoxyuridine monophosphate (CldUMP); in turn, this increases tumor concentrations of CldUMP which is then further anabolized and incorporated selectively into tumor DNA as CldU (5-chloro-2'-deoxyuridine). (NCI04)
C869	Thalicarpine	Multidrug_Resistance_Modulator|Vinca_Alkaloid_Compound	Thalicarpine|4H-Dibenzo[de,g]quinoline, 5,6,6a, 7-tetrahydro-9-[4,5-dimethoxy-2-[(1,2,3,4-tetrahydro-6, 7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]phenoxy]-1,2, 10-trimethoxy-6-methyl-|4H-Dibenzo[de,g]quinoline, 5,6,6a, 7-tetrahydro-9-[4,5-dimethoxy-2-[(1,2,3,4-tetrahydro-6, 7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]phenoxy]-1,2,10-trimethoxy-6-methyl-|4H-Dibenzo[de,g]quinoline, 9-[4, 5-dimethoxy-2-[(1,2,3,4-tetrahydro-6, 7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]phenoxy]-5,6,6a, 7-tetrahydro-1,2,10-trimethoxy-6-methyl-, [S-(R*,R*)]- (9CI)|4H-dibenzo[de,g]quinoline, 9-[4, 5-dimethoxy-2-[(1,2,3,4-tetrahydro-6, 7-dimethoxy-2-methyl-1-isoquinolinyl)methyl]phenoxy]-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, [S-(R*,R*)]- (9CI)|6a.Alpha.-aporphine, 9-[[4, 5-dimethoxy-.alpha.-(1.beta.,2,3,4-tetrahydro-6, 7-dimethoxy-2-methyl-1-isoquinolyl)-o-tolyl]oxy]-1,2, 10-trimethoxy- (8CI)|6a.Alpha.-aporphine, 9-[[4,5-dimethoxy-.alpha.-((S)-1,2,3, 4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolyl)-o-tolyl]oxy]-1, 2,10-trimethoxy-|6a.alpha.-Aporphine, 9-[[4, 5-dimethoxy-.alpha.-(1.beta.,2,3,4-tetrahydro-6, 7-dimethoxy-2-methyl-1-isoquinolyl)-o-tolyl]oxy]-1,2, 10-trimethoxy- (8CI)|6a.alpha.-Aporphine, 9-[[4,5-dimethoxy-.alpha.-((S)-1,2,3, 4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolyl)-o-tolyl]oxy]-1, 2,10-trimethoxy-|NSC 68075|Taliblastine|Thaliblastine|Thalicarpin|[S-(R*,R*)]-9-[4,5-dimethoxy-2-[(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl)-methyl]phenoxy]-5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-4H-dibenzo[de,g]quinoline	A natural aporphine benzylisoquinoline vinca alkaloid with antineoplastic activity. Thalicarpine binds to and inhibits p-glycoprotein, the multidrug resistance efflux pump. Thalicarpine also induces single-strand breaks in DNA and arrests cancer cells at the G2/M and G1 phase of the cell cycle. (NCI04)
C870	Thalidomide	Endothelial_Cell_Inhibitor|Immunosuppressant	Thalidomide|(+)-Thalidomide|(-)-Thalidomide|.alpha.-Phthalimidoglutarimide|2, 6-Dioxo-3-phthalimidopiperidine|2,6-Dioxo-3-phthalimidopiperidine|2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione|3-Phthalimidoglutarimide|Alpha-Phthalimidoglutarimide|Contergan|Distaval|Kevadon|N-(2,6-Dioxo-3-piperidyl)phthalimide|N-Phthaloylglutamimide|N-Phthalylglutamic Acid Imide|N-Phthalylglutamic acid imide|Neurosedyn|Pantosediv|Phthalimide, N-(2, 6-dioxo-3-piperidyl)-, (+)-|Phthalimide, N-(2, 6-dioxo-3-piperidyl)-, (-)-|Sedalis|Sedoval K-17|Softenon|Synovir|THALIDOMIDE|Talimol|Thalomid|thalidomide	A drug that belongs to the family of drugs called angiogenesis inhibitors. It prevents the growth of new blood vessels into a solid tumor.
C871	Thebaine	Opiate	Thebaine
C872	Theophylline	Bronchodilator|Multidrug_Resistance_Modulator	Theophylline|1,3-Dimethylxanthine Monohydrate|3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione|3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione Monohydrate|Constant-T|Elixophyllin|LaBID|Respbid|Slo-Phyllin|Slo-bid|Somophyllin-CRT|Somophyllin-T|T-Phyl|THEOPHYLLINE|Theo-24|Theobid Duracap|Theochron|Theophylline Monohydrate|Uniphyl|theophylline	A drug used to improve breathing in people who are short of breath. It belongs to the family of drugs called bronchodilators or respiratory smooth muscle relaxants.
C873	Thiabendazole	Antihelminthic_Agent	Thiabendazole|MK 360|MK-360|Mintezol|THIABENDAZOLE|Thibenzole
C874	Thiamine	B_Vitamin	Thiamine|B1 Vitamin|THIAMINE|Thiamin|Vit B1|Vitamin B1|Vitamin-B1	A heat-labile and water-soluble vitamin contained in milk, yeast, synthesized; in the germ and husk of grains, also artificially synthesized; essential for growth; a deficiency of thiamin is associated with beriberi and Wernicke-Korsakoff's syndrome. SYN aneurine, antiberiberi factor, antiberiberi vitamin, antineuritic factor, antineuritic vitamin, thiamine, vitamin B1.
C875	Thiotepa	Ethylenimine_Compound	Thiotepa|1,1',1"-phosphinothioylidynetrisaziridine|1,1',1''-Phosphinothioyldynetrisaziridine|1,1',1''-Phosphinothioylidynetrisaziridine|Girostan|Ledertepa|N,N', N''-Triethylenethiophosphoramide|N,N',N''-triethylenethiophosphoramide|NSC 6396|Onco Tiotepa|Oncotiotepa|STEPA|TESPA|THIOTEPA|TIO TEF|TSPA|Tespamin|Tespamine|Thio-Tepa|Thiofosfamide|Thiofozil|Thiophosphamide|Thiophosphoramide|Thioplex|Thiotef|Tifosyl|Tio-TEF|Tio-tef|Triethylene Thiophosphoramide|Triethylene thiophosphoramide|Triethylenethiophosphoramide|Tris(1-aziridinyl)phosphine sulfide|WR 45312|thiotepa|triethylenethiophosphoramide|tris(1-aziridinyl)phosphine sulfide	A synthetic alkylating agent. Related to nitrogen mustard, thiotepa alkylates and crosslinks DNA, resulting in the inhibition of DNA replication. (NCI04)
C876	Thioguanine	Purine_Antagonist	Thioguanine|2-Amino 6MP|2-Amino-1,7-dihydro-6H-purine-6-thione|2-Amino-6-mercaptopurine|2-Amino-6-purinethiol|2-Aminopurin-6-thiol|2-Aminopurine-6(1H)-thione|2-Aminopurine-6-thiol|2-Mercapto-6-aminopurine|6 Mercaptoguanine|6 Thioguanine|6-Amino-2-mercaptopurine|6-Mercapto-2-aminopurine|6-Mercaptoguanine|6-TG|6-Thioguanine|6H-Purine-6-thione, 2-amino-1,7-dihydro- (9CI)|BW 5071|Lanvis|NSC 752|THIOGUANINE|Tabloid|Tioguanin|Tioguanine|WR-1141|Wellcome U3B|X 27|thioguanine	A synthetic guanosine analogue antimetabolite. Phosphorylated by hypoxanthine-guanine phosphoribosyltransferase, thioguanine incorporates into DNA and RNA, resulting in inhibition of DNA and RNA syntheses and cell death. This agent also inhibits glutamine-5-phosphoribosylpyrophosphate amidotransferase, thereby inhibiting purine synthesis. (NCI04)
C877	Thioinosine	Immunosuppressant|Purine_Antagonist	Thioinosine|6-Mercaptopurine ribonucleoside|6-Mercaptopurine riboside|6-mercaptopurine ribonucleoside|6-mercaptopurine riboside|Mercaptopurine Riboside|NSC 4911|inosine, 6-thio|ribosyl-6-mercaptopurine	A sulfhydryl analog of inosine that inhibits nucleotide transport and exhibits immunosuppressive activity. Clinical Use: Leukemia.(NCI)
C878	Recombinant_Human_Thrombopoietin	Therapeutic_Colony_Stimulating_Factor	Recombinant Human Thrombopoietin|C-MPL Ligand|Megakaryocyte Growth and Development Factor|Recombinant Human TPO|rhTPO
C879	Thromboxane	Eicosanoid	Thromboxane
C880	Thymidine	Nephroprotective_Agent	Thymidine|2'-Deoxythymidine|DThyd|TdR|Thymidin|Thymidine Deoxyriboside|thymidine	A chemical compound found in DNA. Also used as treatment for mucositis.
C881	Thymine	Pyrimidine	Thymine|2,4-dihydroxy-5-methylpyrimidine|5-Methyl-2,4(1H,3H)-pyrimidinedione|5-Methyluracil|THYMINE	2,4-diketo-5-methylpyrimidine; one of the 5 major bases (with adenine, guanine, cytosine, and uracil) found in nucleic acids.
C882	Thymopoietin	Peptide_Hormone	Thymopoietin	Human thymopoietin is a peptide hormone that is produced in the thymus. It is comprised of two closely-related polypeptide hormones (each ~ 7kD) and functions to induce differentiation of prothymocytes to thymocytes. Mutations in thymopoietin can delay or impair neuromuscular transmission. It has been implicated in both the structural organization of the nucleus and in post-mitotic nuclear assembly.
C883	Recombinant_Thymosin	Miscellaneous_Biologic_Response_Modifier|Miscellaneous_Hormone_Agent	Recombinant Thymosin|Thymosin	A recombinant form of an immune hormone secreted by the thymus gland that stimulates the immune system by potentiating the differentiation and maturation of T-lymphocytes. (NCI)
C884	Therapeutic_Thyroglobulin	Thyroid_Agent	Recombinant Thyroglobulin|Therapeutic TG|Thyroglobulin|thyroglobulin	(THIGH-roe-GLOB-yu-lin) The form that thyroid hormone takes when stored in the cells of the thyroid. If the thyroid has been removed, thyroglobulin should not show up on a blood test. Doctors measure thyroglobulin level in blood to detect thyroid cancer cells that remain in the body after treatment.
C885	Antithyroid_Agent	Hormone_Antagonist	Antithyroid Agent
C886	Thyroid_Hormone	Hormone	Thyroid Hormone|Thyroid Gland Hormone|thyroid hormone	Any of several closely related compounds that are produced by the thyroid gland and are active metabolically.
C887	Recombinant_Thyroid-Stimulating_Hormone	Pituitary_Agent	Recombinant Thyroid-Stimulating Hormone|Recombinant TSH|Thyroid Stimulating Hormone|Thyrotropin|thyroid-stimulating hormone	A peptide hormone secreted by the anterior pituitary. It promotes the growth of the thyroid gland and stimulates the synthesis of thyroid hormones and the release of thyroxine by the thyroid gland.
C888	Therapeutic_Levothyroxine	Thyroid_Agent	Levothyroxine Sodium|(-)-Thyroxine|L-Thyroxine|LEVOTHYROXINE SODIUM|Levothyroxine|Levothyroxine sodium|Sodium levothyroxine|Therapeutic Levothyroxine|Thyroxine
C889	Ticarcillin	Extended_Spectrum_Penicillin_Antibiotic	Ticarcillin|Ticar
C890	Tinidazole	Trichomonacide_Agent	Tinidazole|Fasigyn|Simplotan|TINIDAZOLE|tinidazole	A drug used to treat protozoal infections, such as amebiasis, giardiasis, and trichomoniasis. It belongs to a family of drugs called antiprotozoal agents. Tinidazole is also being evaluated in the treatment of Helicobacter pylori infections in people with low-grade gastric lymphoma.
C891	Tobacco	Substance_of_Abuse	Tobacco|TOBC	The dried cured leaves of the tobacco plant, Nicotiana tabacum, used for smoking, chewing, or snuff.  Tobacco contains nicotine, a stimulant, and other biologically active ingredients having carcinogenic properties.(NCI)
C892	Smokeless_Tobacco	Tobacco	Smokeless Tobacco|Smoking, Tobacco and Cancer - Smokeless Tobacco	Tobacco that is not smoked but used in another form such as chewing tobacco or snuff.
C893	Tobramycin	Aminoglycoside_Antibiotic	Tobramycin Sulfate|TOBRAMYCIN|TOBRAMYCIN SULFATE|Tobramycin|Tobrex
C894	Toxin	Chemical_Modifier	Toxin|Toxins|toxins	A chemical, physical, or biological agent that causes disease or some alteration of the normal structure and function of an organism. Usually refers to poisonous substance produced during the metabolism and growth of certain microorganisms and some higher plant and animal species, or any poisonous isomer, homolog, or derivative of such a substance. It causes either permanent or reversible injury to the health of a living thing on contact or absorption, typically by interacting with biological macromolecules such as enzymes and receptors. Onset of effects may be immediate or delayed, and impairments may be slight or severe. (NCI)
C895	Chromomycin_A3	Chromomycin_Antibiotic|DNA_Minor_Groove_Binding_Agent	Chromomycin A3|3B-O-(4-O-Acetyl-2,6-dideoxy-3-C-methyl-alpha-L-arabino-hexopyranosyl)-7-methylolivomycin D|Aburamycin B|Antibiotic B 599|Antibiotic from Streptomyces griseus|CHROMOMYCIN A3|Chromomycin A-3|NSC-58514|Olivomycin D, 3B-O-(4-O-Acetyl-2, 6-dideoxy-3-C-methyl-.alpha.-L-arabino-hexopyranosyl)-7-methyl- (9CI)|Olivomycin D, 3B-O-(4-O-acetyl-2, 6-dideoxy-3-C-methyl-.alpha.-L-arabino-hexopyranosyl)-7-methyl- (9CI)|TOYOMYCIN|Toyomycin	A glycosidic antineoplastic antibiotic isolated from the bacterium Streptomyces griseus.  Chromomycin A3 reversibly binds to guanine-cytosine (G-C) base pairs in the minor groove of DNA, thereby inhibiting RNA synthesis.  This agent is used as a fluorescent chromosome dye. (NCI04)
C896	Trace_Element	Element_or_Isotope	Trace Element|Micronutrient|Trace Mineral|Trace Nutrient|trace element	A chemical found in very small amounts in a given substance. Organisms need certain trace elements to survive.
C897	Therapeutic_Transforming_Growth_Factor-Alpha	Therapeutic_Transforming_Growth_Factor	Recombinant Transforming Growth Factor-Alpha|Epidermal Growth Factor Related Transforming Growth Factor|Therapeutic TGF A|Therapeutic TGF-Alpha|Transforming Growth Factor (34-43)-alpha|Transforming Growth Factor-alpha	A recombinant form of Transforming Growth Factor-Alpha, a polypeptide growth factor involved with the growth and differentiation of epidermal and epithelial cells, playing a role in phenotypic transformation.  It is structurally and functionally similar to Epidermal Growth Factor (EGF) and binds to the same receptor.
C898	Therapeutic_Transforming_Growth_Factor-Beta	Therapeutic_Transforming_Growth_Factor	Recombinant Transforming Growth Factor-Beta|Bone-Derived Transforming Growth Factor|Therapeutic Milk Growth Factor|Therapeutic TGF B|Therapeutic TGF-Beta|Transforming Growth Factor Beta|rTGF-Beta	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine transforming growth factor-beta (TGF-beta) with proapoptotic and antineoplastic properties. TGF-beta may suppress tumor cell growth by decreasing the expression of cyclin D1, a cell cycle regulatory protein, and downregulating the expression of the oncogene c-myc. This agent is also involved in T cell-mediated immunosuppression by CD4+CD25+ T cells, which permits cancer cells to evade immune surveillance. (NCI04)
C899	Therapeutic_Transforming_Growth_Factor	Therapeutic_Growth_Factor	Recombinant Transforming Growth Factor|TGF|Transforming Growth Factor|Tumor Growth Factors	A recombinant therapeutic agent which is chemically identical to or similar to endogenous transforming growth factor (TGF).  Representing peptides of two distinct classes, designated TGF-alpha and TGF-beta, TGFs are produced by various non-transformed cells during the development of mammalian embryos and are found in urine and plasma; TGFs are also produced by some human carcinomas and cell lines transformed by viral and cellular oncogenes.  TGFs affect bone formation and remodeling by inhibition of the synthesis of collagen and release of calcium. (NCI04)
C900	Vitamin_A_Acid	Retinoic_Acid_Agent	Tretinoin|(All-E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid|2,4,6,8-Nonatetraenoic acid, 3, 7-dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (all-E)-|ATRA|Aberel|Airol|Aknoten|All-Trans Retinoic Acid|All-trans Retinoic Acid|All-trans Vitamin A Acid|Avita|Cordes Vas|Dermairol|Epi-Aberel|Eudyna|Renova|Retin-A|Retin-A MICRO|Retinoic Acid|Retinoic acid, trans-|Retisol-A|Ro 5488|Stieva-A|Stieva-A Forte|TRETINOIN|Trans Retinoic Acid|Trans Vitamin A Acid|Tretinoinum|Vesanoid|Vitamin A Acid|Vitamin A acid|Vitamin A acid, all-trans-|Vitinoin|all trans-Retinoic acid|all-trans-Retinoic acid|all-trans-Vitamin A acid|beta-Retinoic Acid|trans-Retinoic Acid|trans-Retinoic acid|tretinoin	A drug that belongs to the family of drugs called retinoids. It is used in the treatment of acne and is being studied in cancer prevention.
C901	Triamcinolone	Therapeutic_Glucocorticoid	Triamcinolone|(11beta,16alpha)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione|Aristocort|TRIAMCINOLONE|triamcinolone	(try-am-SIN-oh-lone) A substance that is being studied for the prevention of nonmelanoma skin cancer.  It is an anti-inflammatory drug that is applied to the skin to relieve irritation, rashes, and infections.  It belongs to the family of drugs called topical corticosteroids.
C902	Triazene_Compound	Antineoplastic_Alkylating_Agent	Triazene Compound|Triazene Compounds	An organic compound having hydrogen and at least two directly attached nitrogen atoms, which are attached by double or triple bonds. (NCI)
C903	Triaziquone	Ethylenimine_Compound	Triaziquone
C904	Trifluoperazine	Multidrug_Resistance_Modulator|Phenothiazine	Trifluoperazine Hydrochloride|10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-10H-phenothiazine|10-[3-(4-Methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)-10H-phenothiazine|Eskazine|Jatroneural|SKF 5019|Stelazine|TFP|TRIFLUOPERAZINE HYDROCHLORIDE|Terfluzine|Trifluoperazine|Trifluoperazine Dihydrochloride
C905	Trifluridine	Nucleic_Acid_Synthesis_Inhibitor	Trifluridine|2'-Deoxy-5-trifluoromethyluridine|TRIFLURIDINE|Triflorothymidine	A fluorinated thymidine analog with potential antineoplastic activity. Trifluridine is incorporated into DNA and inhibits thymidylate synthetase, resulting in inhibition of DNA synthesis, inhibition of protein synthesis, and apoptosis. This agent also exhibits antiviral activity. (NCI04)
C906	Triglycerides	Lipid	Triglycerides|TG|Triglyceride	Fats composed of three fatty acid chains linked to a glycerol molecule.
C907	Therapeutic_Triiodothyronine	Thyroid_Agent	Therapeutic Triiodothyronine|L-Triiodothyronine|Liothyronine|Therapeutic T3|Triiodothyronine|triiodothyronine	A therapeutic formulation of the primary physiologically active form of endogenous thyroid hormone. In vivo, triiodothyronine enters the nucleus and binds to nuclear thyroid hormone receptors that subsequently bind to thyroid response elements (TREs) located in target genes. Receptor binding by triiodothyronine in combination with recruited coactivators results in maximal transcriptional activation after binding to TREs; in general, binding of thyroid hormone receptor alone to TREs leads to repression of gene transcription (NCI04)
C908	Trimethoprim	Urinary_Anti-Infective_Agent	Trimethoprim|2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine|Proloprim|TRIMETHOPRIM|Trimpex	A synthetic derivative of trimethoxybenzyl-pyrimidine with antibacterial and antiprotozoal properties.  As a pyrimidine inhibitor of bacterial dihydrofolate reductase, trimethoprim binds tightly to the bacterial enzyme, blocking the production of tetrahydrofolic acid from dihydrofolic acid.  The antibacterial activity of this agent is potentiated by sulfonamides. (NCI04)
C909	Trimethoprim-Sulfamethoxazole	Combination_Anti-Infective_Agent	Trimethoprim-Sulfamethoxazole|Bactrim|Centran|Centrin|Co-Trimoxazole|Co-Trimoxazole (Bactrim DS)|Cotrim|Cotrimoxazole|Eslectin|Insozalin|SMZ-TMP|TMP-SMX|Trimedin|Trimezole|co-trimoxazole|trimethoprim-sulfamethoxazole	A combination of two anti-infection drugs, sulfamethoxazole and trimethoprim. It is used to fight bacterial and protozoal infections.
C910	Trypan_Blue	Dye	Trypan Blue|Benzamine Blue|C34H28N6O14S4	An acid azo dye commonly used as a stain to distinguish viable from non-viable cells. It turns dead cells blue and viable cells unstained. It is a known animal carcinogen and an experimental teratogen.
C911	Tubercidin	Miscellaneous_Antineoplastic_Antibiotic|Purine_Antagonist	Tubercidin|4-Amino-7-.beta.-D-ribofuranosyl-7H-pyrrolo[2, 3-d]pyrimidine|4-Amino-7.beta.-D-ribofuranosyl-7H-pyrrolo(2, 3-d)pyrimidine|4-amino-7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidine|7-Deazaadenosine|7-beta-D-ribofuranosyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine|7-deazaadenosine|7H-Pyrrolo(2,3-d)pyrimidine, 4-amino-7.beta.-D-ribofuranosyl-|7H-Pyrrolo[2,3-d]pyrimidine, 4-amino-7-.beta.-D-ribofuranosyl-|U 10071|U-10071	An antibiotic and adenosine analog isolated from the bacterium Streptomyces tubercidicus with potential antineoplastic activity.  Tubercidin is incorporated into DNA and inhibits polymerases, thereby inhibiting DNA replication and RNA and protein synthesis.  This agent also exhibits antifungal and antiviral activities. (NCI04)
C912	Tumor_Antigen	Antigen	Tumor Antigen|Tumor-Associated Antigen|tumor-specific antigen	1. antigens that may be frequently associated with tumors or may be specifically found on tumor cells of the same origin (tumor specific); 2. tumor antigens may also be associated with replication and transformation by certain DNA tumor viruses, including adenoviruses and papovaviruses. Neoantigens. Any immunologically detectable marker whose presence or amount indicates the presence of a tumor.
C913	Therapeutic_Tumor_Necrosis_Factor-Alpha	Therapeutic_Tumor_Necrosis_Factor_Family_Protein	Recombinant Tumor Necrosis Factor-Alpha|Cachectin|TNF-Alpha|TNFA|Tumor Necrosis Factor|Tumor Necrosis Factor (TNF-alpha)	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine tumor necrosis factor-alpha with antineoplastic properties.  Tumor necrosis factor-alpha binds to and activates "death receptors" on the cell surface, resulting in apoptosis and cell death by the p53-independent extrinsic pathway. This agent also disrupts tumor vascularization. (NCI04)
C914	Tumor_Promoter	Chemical_Modifier	Tumor Promoter	An agent that acts at stage 2 of carcinogenesis, following the initiation of increased cell proliferation.  It is a necessary step in overt tumor formation.
C915	Tyrosine	Non-Essential_Amino_Acid	Tyrosine|(.+-.)-Tyrosine|L-Tyrosine|TYR|TYROSINE, (L)
C916	Coenzyme-Q	Antioxidant|Quinone_Compound	Coenzyme-Q|2-(3,7,11,15,19,23,27,31,35,39-Decamethyl-2,6,10,14,18,22,26,30,34,38-tetracontadecanyl)-5,6-dimethoxy-3-methyl-2,5-cyclohexadiene-1,4-dione|Co-Q10|Coenzyme Q10|Ubidecarenone|Ubiquinone|Ubiquinone 10	A naturally occurring benzoquinone important in electron transport in mitochondrial membranes. Coenzyme-Q functions as an endogenous antioxidant; deficiencies of this enzyme have been observed in patients with many different types of cancer and limited studies have suggested that coenzyme-Q may induce tumor regression in patients with breast cancer. This agent may have immunostimulatory effects. (NCI04)
C917	Uracil	Pyrimidine	Uracil|2, 4-Dioxopyrimidine|2,4(1H,3H)-pyrimidinedione|2,4-Pyrimidinediol|2,4-dioxopyrimidine|2,4-pyrimidinediol|2-hydroxy-4-(1H)-pyrimidione|2-hydroxy-4-(3H)-pyrimidione|4-hydroxy-2-(1H)-pyrimidione|URACIL|uracil	2,4-diketopyrimidine; one of the 5 major bases (with adenine, guanine, cytosine, and thymine) which are a component of nucleic acids.
C918	Uracil_Mustard	Nitrogen_Mustard_Compound	Uracil Mustard|5-(bis-(2-Chloroethyl) Amino) Uracil|5-[Bis(2-chloroethyl)amino]uracil|U 8344|U-8344|Uramustine
C919	Urea_Nitrogen	Nitrogen_Compound	Urea Nitrogen|Urea
C920	Urethan	Organo-nitrogen_Carcinogen	Urethan|Carbamic acid ethyl ester|Ethyl Carbamate|Ethyl Urethan|Ethyl carbamate|Ethyl urethan|Urethane|carbamic acid, ethyl ester	A colorless and odorless, crystalline compound that emits toxic fumes of nitrogen oxides when heated to decomposition. Urethan is mainly used in the production of amino resins, but is also used in the manufacture of pesticides, fumigants, cosmetics and pharmaceuticals. Exposure to urethan can affect the central nervous system, liver and can cause bone marrow suppression. Urethan is reasonably anticipated to be a human carcinogen. (NCI05)
C921	Uricosuric_Agent	Miscellaneous_Chemoprotective_Agent	Uricosuric Agent|Hyperuricaemia Agents
C922	Uridine	Cytoprotective_Agent	Uridine|Urd	A nucleoside consisting of uracil and D-ribose and a component of RNA.  Uridine has been studied as a rescue agent to reduce the toxicities associated with 5-fluorouracil (5-FU), thereby allowing the administration of higher doses of 5-FU in chemotherapy regimens. (NCI04)
C923	Vaccine	Biological_Agent|Biological_Response_Modifier	Vaccine|VAC|vaccine	A substance or group of substances meant to cause the immune system to respond to a tumor or to microorganisms, such as bacteria or viruses. A vaccine can help the body recognize and destroy cancer cells or microorganisms.
C924	Mould_Element	Depsipeptide_Antibiotic	Mould Element|Cyclododecadepespipeptide Neutral Ionophore|VALINOMYCIN|Valinomycin	A cyclic depsipeptide isolated from the bacterium Streptomyces fulvissimus.  As a potassium-specific ionophore, mould element causes loss of mitochondrial membrane potential, thereby initiating cellular apoptosis. (NCI04)
C925	Vancomycin	Miscellaneous_Antibiotic	Vancomycin|Vancocin Hydrochloride|vancomycin	An antibiotic drug used to fight resistant bacterial infections.
C926	Therapeutic_Vasopressin	Pituitary_Agent	Recombinant Vasopressin|Antidiuretic Hormone|Therapeutic ADH|Vasopressin	A nonapeptide hormone released by the posterior lobe of the pituitary whose primary function is regulating extracellular fluid volume.  It can also act as a vasoconstrictor, increasing blood pressure and systemic vascular resistance.
C927	Drug_Vehicle	Industrial_Aid	Drug Vehicle
C928	Verapamil	Calcium_Channel_Blocker	Verapamil|Verapamil SR|alpha-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-alpha-(1-methylethyl)benzeneacetonitrile	A phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility.  This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
C929	Vidarabine	Nucleic_Acid_Synthesis_Inhibitor	Vidarabine|9-Beta-D-arabinofuranosyl-9H-purine-6-amine Monohydrate|9-Beta-D-arabinofuranosyladenine Monohydrate|ARA-A|Adenine Arabinoside|Ara-A|Arabinosyladenine|Arasena-A|Beta Ara-A|CI-673|Spongoadenosine|VIDARABINE|Vira-A	A nucleoside antibiotic isolated from the bacterium Streptomyces antibioticus with antineoplastic activity. Vidarabine inhibits DNA polymerase, resulting in the inhibition of DNA replication in tumor cells. (NCI04)
C930	Vinblastine	Vinca_Alkaloid_Compound	Vinblastine|VLB|Vincaleucoblastine|vinblastine	A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)
C931	Vinblastine_Sulfate	Vinblastine	Vinblastine Sulfate|29060 LE|29060-LE|Exal|VINBLASTINE SULFATE|VINCALEUKOBLASTINE|Velban|Velbe|Velsar	The sulfate salt of vinblastine, a natural alkaloid isolated from the plant Catharanthus roseus (Madagascar periwinkle) with antineoplastic properties.  Vinblastine disrupts microtubule formation and function during mitosis and interferes with glutamic acid metabolism. (NCI04)
C932	Vinca_Alkaloid_Compound	Antineoplastic_Plant_Product|Tubulin_Binding_Agent	Vinca Alkaloid Compound|Vinca Alkaloids|vinca alkaloids	Anticancer drugs that inhibit cancer cell growth by stopping cell division. They are also called antimitotic or antimicrotubule agents, or mitotic inhibitors.
C933	Vincristine	Vinca_Alkaloid_Compound	Vincristine|22-Oxovincaleukoblastine|LEUROCRISTINE|Leurocristine|VCR|VINCRISTINE|Vincrystine|vincristine	A natural alkaloid isolated from the plant Vinca rosea Linn. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)
C934	Vindesine	Vinca_Alkaloid_Compound	Vindesine|3-(Aminocarbonyl)-O4-deacetyl-3-de-(methoxycarbonyl)vincaleukoblastine|Compound 112531|DAVA|DVA|Deacetyl Vinblastine Carboxamide|Deacetylvinblastine Carboxamide|Desacetylvinblastine Amide|Lilly CT-3231|VDS|VINDESINE|vindesine	A synthetic derivative of vinblastine, a naturally occurring vinca alkaloid. Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI04)
C935	Vindesine_Sulfate	Vindesine	Vindesine Sulfate|Desacetyl Vinblastine Amide Sulfate|Eldisin|Eldisine|Enison|Gesidine|LY-099094|NSC 245467|Vindesine Sulphate|Vindesine sulfate|Vindesini Sulfas	The sulfate salt form of Vindesine.  Vindesine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI)
C936	Vinyl_Chloride	Carcinogenic_Chlorinated_Hydrocarbon|Halogenated_Hydrocarbon	Vinyl Chloride|Chloroethene|Choroethylene|vinyl chloride	(VINE-uhl KLOR-ide) A substance used to make plastics. Exposure to vinyl chloride may increase the risk of developing liver, brain, and lung cancers; lymphoma; and leukemia.
C937	Virginiamycin	Depsipeptide_Antibiotic	Virginiamycin|Antibiotic No. 899|Eskalin (Vet)|Mikamycin|RP 7293|SKF-7988|Stafac|Staphylomycin|Staphylomycine|VIRGINIAMYCIN|Virgimycine	A class of streptogramin-related depsipeptides isolated from the bacterium Streptomyces virginiae and other Streptomyces bacterial species.  The virginiamycins consist of two major components, virginiamycin M1 and virginiamycin S1.  These agents bind to and inhibit ribosome assembly, thereby preventing protein synthesis.  Active against Gram-positive bacteria, these antibiotics are primarily used in veterinary practice. (NCI04)
C938	Vitamin_A	Fat-Soluble_Vitamin|Retinoic_Acid_Agent	Vitamin A|3,7-Dimethyl-9-(2,6, 6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol|3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraen-1-ol|A 313|All Trans Retinol|Anti-Infective Vitamin|Anti-Infective vitamin|Antixerophthalmic Vitamin|Antixerophthalmic vitamin|Aquasol A|Arovit|Avibon|Avitol|Axerol|Axerophthol|Axerophtholum|Biosterol|Biovit-A|Del-VI-A|Del-Vi-A|Ido A 50|Idrurto A|Lard Factor|Lard-Factor|Ledovit A|Micelle A|Mulsal A Megadosis|Oleovitamin A|Ophthalamin|Pedi-Vit-A|Retinol|Retinol, all trans-|Rinocusi Vitaminico|Vitamin A Alcohol|Vitamin A USP|Vitamin A1|Vitaminoftalmina|Vitaminum A|Vogan|all-trans-Retinol|retinol|vitamin A	The fat soluble vitamin retinol.  Vitamin A binds to and activates retinoid receptors (RARs), thereby inducing cell differentiation and apoptosis of some cancer cell types and inhibiting carcinogenesis.  Vitamin A plays an essential role in many physiologic processes, including proper functioning of the retina, growth and differentiation of target tissues, proper functioning of the reproductive organs, and modulation of immune function. (NCI04)
C939	Vitamin_B12	B_Vitamin	Vitamin B12|B12 Vitamin|Cyanocobalamin|Cyanocobalamin (Vitatmin B12)|VIT B12|Vitamin-B12	An essential nutrient and natural water-soluble vitamin of the B-complex family that must combine with an intrinsic factor for absorption by the intestine, Vitamin B12 (cyanocobalamin) is necessary for hematopoiesis, neural metabolism, DNA and RNA production, and carbohydrate, fat, and protein metabolism. B12 improves iron functions in the metabolic cycle and assists folic acid in choline synthesis. B12 metabolism is interconnected with that of folic acid. Vitamin B12 deficiency causes pernicious anemia, megaloblastic anemia, and neurologic lesions. (NCI04)
C940	Vitamin_B_Complex	Water-Soluble_Vitamin	Vitamin B Complex|Neurobion|Vitamin B	A compound containing several or all of the B-vitamins, including thiamine, riboflavin, niacin (nicotinic acid), niacinamide (nicotinamide), the vitamin B6 group (including pyridoxine, pyridoxal, pyridoxamine), biotin, pantothenic acid, folic acid, possibly para-aminobenzoic.
C941	Vitamin_D	Fat-Soluble_Vitamin	Vitamin D|D vitamin|VIT D|Vitamin-D	A family of lipo-soluble steroids important to the absorption, metabolism, and function of calcium and phosphorus and the growth and development of bone and tooth enamel. Found naturally in animal tissues, cholecalciferol (vitamin D3) is formed in the skin when ultraviolet light activates cholesterol conversion into vitamin D3. Ultraviolet irradiation of ergosterol (plant vitamin D) forms ergocalciferol (vitamin D2). (NCI04)
C942	Vitamin_E	Antioxidant|Fat-Soluble_Vitamin|Miscellaneous_Angiogenesis_Inhibitor	Vitamin E|(+/-)-alpha-Tocopherol|3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol|5,7,8-Trimethyltocol|E Vitamin|d-alpha-Tocopherol|vitamin E	A natural fat-soluble antioxidant with potential chemopreventive activity. Also known as tocopherol, vitamin E ameliorates free-radical damage to biological membranes, protecting polyunsaturated fatty acids (PUFA) within membrane phospholipids and within circulating lipoproteins. Peroxyl radicals react 1000-fold faster with vitamin E than with PUFA.  In the case of oxygen free radical-mediated tumorigenesis, vitamin E may be chemopreventive. (NCI04)
C943	Vitamin_K	Fat-Soluble_Vitamin|Quinone_Compound	Vitamin K|Phylloquinone|vitamin K	A substance that promotes the clotting of blood.
C944	Vitamin	Nutrient	Vitamin|Vitamins|Vitamins Total|vitamins	A group of organic food substances found in animals and plants in small quantities. They must be supplied in diet or dietary supplement and are essential for normal metabolism.
C945	Warfarin	Coumarin	Warfarin|1-(4'-Hydroxy-3'-coumarinyl)-1-phenyl-3-butanone|3-(.alpha.-Acetonylbenzyl)-4-hydroxycoumarin|3-(.alpha.-Phenyl-.beta.-acetylethyl)-4-hydroxycoumarin|3-(Alpha-acetonylbenzyl)-4-hydroxycoumarin|3-Alpha-phenyl-beta-acetylethyl-4-hydroxycoumarin|4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one|Athrombin-K|Co-Rax|Compound 42|Rodex|WARF Compound 42|WARF compound 42|warfarin	A drug that prevents blood from clotting. It belongs to the family of drugs called anticoagulants (blood thinners).
C946	Pentosan_Polysulfate_Sodium	Pentosan_Polysulfate	Pentosan Polysulfate Sodium|Cartrophen|Elmiron|Fibrase|Fibrezym|Hemoclar|Pentosan|SP-54|Sodium Pentosan Polysulfate|Sodium Xylan Polysulfate|Thrombocid	A semi-synthetic glucosaminoglycan analog of heparin with anticoagulant, chondroprotective, anti-inflammatory, antiangiogenic and antiviral properties.  Pentosan polysulfate binds to and inhibits the actions of overactive leukocytes; decreases the production of tumor necrosis factor (TNF alpha) and increases interleukin 6 synthesis in order to provide an anti-inflammatory effect; inhibits angiogenesis and tumorigenesis by blocking the basic fibroblast growth factor (bFGF) binding to its cell surface receptor; and binds to and inhibits human immunodeficiency virus 1 (HIV-1) Tat protein, a pleiotropic heparin-binding growth factor involved in AIDS pathogenesis. (NCI04)
C947	Zidovudine	Anti-HIV_Agent|Reverse_Transcriptase_Inhibitor	Zidovudine|3'-Azido-3'-deoxythymidine|AZT|Azidothymidine|Aztec|BW-A509U|Retrovir|ZDV|ZIDOVUDINE|zidovudine	A drug that inhibits the human immunodeficiency virus (HIV) that causes AIDS. Also called AZT. It belongs to the family of drugs called systemic antivirals.
C948	Zinc	Metals|Trace_Element	Zinc|Zn	An element with atomic symbol Zn, atomic number 30, and atomic weight 65.39.
C949	Zinc_Oxide	Sunscreen	Zinc Oxide|C.I. Pigment White 4|zinc oxide	A compound that may enhance immune function, especially when administered by inhalation.
C950	Anaxirone	Epoxide_Compound|Immunosuppressant	Anaxirone|1,2,4-triglycidylurazol|TGU|Triglycidylurazol	A synthetic triepoxide alkylating agent with cytostatic and immunosuppressant properties.  Anaxirone alkylates DNA via actual or derived epoxide groups, resulting in inhibition of DNA synthesis. This agent exhibits a broad spectrum of antineoplastic activity against experimental tumors, including those resistant to other alkylating agents. (NCI04)
C951	Dibenzo_a_h_Anthracene	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	Dibenzo (a,h) anthracene|1,2,5,6-Dibenzanthracene|DB(a,h)A|Dibenz(a,h)anthracene|Dibenzo[a,h]anthracene	A crystalline, carcinogenic aromatic hydrocarbon consisting of five fused benzene rings, produced by the incomplete combustion of organic matter. Dibenzo(a,h)anthracene is primarily found in gasoline exhaust, tobacco smoke, coal tar, soot and certain food products, especially smoked and barbecued foods. This substance is used only for research purposes to induce tumorigenesis. Dibenzo(a,h)anthracene is a mutagen and is reasonably anticipated to be a human carcinogen.
C952	Tesmilifene_Hydrochloride	Chemo_Immunostimulant_Adjuvant|Cytoprotective_Agent|Selective_Estrogen_Receptor_Modulator	Tesmilifene Hydrochloride|BMS-217380-01|BMY-33419|Bis(diphenylphosphine)ethane|DPPE	Belongs to a group of antihormone drugs.
C953	AZP	Unclassified_Chemotherapy_Agent	AZP|1,3-Diaziridino-2,4,6-Triaza-1,3,5,5-Tetraaminomethyl-1,3,5-Triphosphorin|N(3)P(3)Az(2)(NHMe)4	An aziridinyl-substituted cyclophosphazene and a putrescence derivative that may cause DNA cross-linkage. (NCI04)
C954	Tauromustine	Nitrosourea_Compound	Tauromustine|TCNU	1-(2-chloroethyl)-3-(2-(dimethylaminosulfonyl)ethyl)-1-nitrosourea, an antineoplastic agent.
C955	Carmofur	Pyrimidine_Antagonist	Carmofur|1(2H)-Pyrimidinecarboxamide, 5-fluoro-N-hexyl-3,4-dihydro-2,4-dioxo-|1-Hexylcarbamoyl-5-Fluorouracil|HCFU	An antimetabolite (pyrimidine analogue) antineoplastic derivative of 5-fluorouracil. (NCI)
C956	Edelfosine	Antiparasitic_Agent|Protein_Kinase_C_Inhibitor	Edelfosine|1-O-Octadecyl-2-O-methyl-rac-glycero-3-phosphocholine|1-Octadecyl-2-methoxy-rac-glycero-3-phosphocholine|ET-18-OCH3|Edelfosinum|Et-18-OCH3	A synthetic analog of lysophosphatidylcholine, an ether lipid, possessing anti-leishmanial and antineoplastic activity.  The mechanism of action for edelfosine has not been fully elucidated.  Targeting cellular membranes, edelfosine modulates membrane permeability, membrane lipid composition, and phospholipid metabolism.  Edelfosine also inhibits the phosphatidylinositol 3 kinase (PI3K)-AKT/PKB survival pathway, possibly activating the pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis.  In addition, this agent inhibits protein kinase C, intracellular activation of the Fas/CD95 receptor, and intracellular acidification.  Anti-leishmanial activity may be due to inhibition of a glycosomal alkyl-specific-acylCoA acyltransferase. (NCI)
C957	_10-Deacetyltaxol	Taxane_Compound	10-Deacetyltaxol|benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca(3,4)benz(1,2-b)oxet-9-yl ester, (2aR-(2aalpha,4beta,4abeta,6beta,9alpha(alphaR*,betaS*),11alpha,12alpha,12aalpha,12balpha))-	An analog of paclitaxel with antineoplastic activity.  10-Deacetyltaxol binds to and stabilizes the resulting microtubules, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and apoptosis. (NCI)
C958	Edatrexate	Dihydrofolate_Reductase_Inhibitor|Folate_Antagonist	Edatrexate|10-EDAM|10-EdAM|10-Ethyl-10-deaza-aminopterin|CGP-30694|N-[4-[1-[(2, 4-Diamino-6-pteridinyl)-methyl]propyl]benzoyl]-L-glutamic acid|N-[4-[1-[(2,4-Diamino-6-pteridinyl)-methyl]propyl]benzoyl]-L-glutamic Acid|edatrexate	A polyglutamatable folate antagonist analogue of methotrexate with antineoplastic activity. Edatrexate inhibits dihydrofolate reductase, thereby increasing cellular levels of polyglutamates, inhibiting thymidylate synthase and glycinamide ribonucleotide formyl transferase, impairing synthesis of purine nucleotides and amino acids, and resulting in tumor cell death. Edatrexate may overcome tumor resistance to methotrexate, which loses its activity after it is polyglutamated. (NCI04)
C959	_12-Hydroxy-5_8_10_14-Eicosatetraenoic_Acid	Hydroxyeicosatetraenoic_Acid	12-Hydroxy-5,8,10,14-eicosatetraenoic Acid|12-HETE	A lipoxygenase metabolite of arachidonic acid. It is a highly selective ligand used to label mu-opioid receptors in both membranes and tissue sections. The 12-S-HETE analog has been reported to augment tumor cell metastatic potential through activation of protein kinase C. (MeSH)
C960	Hydroxyprogesterone_Caproate	Therapeutic_Progestin	Hydroxyprogesterone Caproate|17-[(1-Oxohexyl)oxy]pregn-4-ene-3,20-dione|17alpha-Hydroxyprogesterone Caproate|Delalutin|Hydroxyprogesterone caproate	A synthetic progestational hormone which in general acts as negative feedback at the level of the hypothalamus and pituitary. It is involved in the regulation of gene transcription. (NCI)
C961	Gemcitabine	Pyrimidine_Antagonist|Ribonucleotide_Reductase_Inhibitor	Gemcitabine Hydrochloride|1-(2-Oxo-4-amino-1,2-dihydropyrimidin-1-yl)-2-deoxy-2,2-difluororibose|2'-Deoxy-2',2'-difluorocytidine|2'Deoxy-2',2'-Difluorocytidine|Difluorodeoxycytidine|GEMCITABINE HYDROCHLORIDE|Gemcitabine|Gemzar|LY-188011|dFdC|dFdCyd|gemcitabine	An anticancer drug that belongs to the family of drugs called antimetabolites.
C962	_2_2_2_Trichlorotriethylamine	Nitrogen_Mustard_Compound	2,2',2''-Trichlorotriethylamine|2,2', 2''-Trichlorotriethylamine	A nitrogen mustard vesicant that has application in chemical warfare, and has been used as a cytostatic alkylating agent in anti cancer therapy.
C963	SarCNU	Nitrosourea_Compound	SarCNU|2-Chloroethyl-3-Sarcosinamide-1-Nitrosourea|sarCNU	An alkylating chloroethylnitrosourea with antineoplastic activity.  Selectively accumulating in some tumor cells, SarCNU forms covalent linkages with nucleophilic centers in DNA, causing depurination, base pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)
C964	Fludeoxyglucose_F_18	Radioconjugate	Fludeoxyglucose F 18|18FDG|2-F18-Fluoro-2-deoxy-D-glucose|2-F18-Fluoro-2-deoxyglucose|FDG|Fluorine-18 2-Fluoro-2-deoxy-D-Glucose|Fluorodeoxyglucose F18|fludeoxyglucose F 18	A positron-emitting radiopharmaceutical containing radioactive 2-deoxy-2-[18F] fluoro-D-glucose. With similar cell uptake as glucose (high in tumor cells), fludeoxyglucose F 18 is not dephosphorylated and further metabolized. (NCI04)
C965	_2-Methoxyestradiol	Endothelial_Cell_Inhibitor|Steroidal_Estrogen	2-Methoxyestradiol|(17beta)-2-Methoxyestra-1,3,5(10)-triene-3,17-diol|2-Methoxy Estradiol|2-methoxyestradiol|2ME2|Panzem	2ME2. A drug derived from estrogen that belongs to the family of drugs called angiogenesis inhibitors.  It prevents the formation of new blood vessels that tumors need in order to grow.
C966	Dichloromethotrexate	Dihydrofolate_Reductase_Inhibitor|Folate_Antagonist	Dichloromethotrexate|3', 5'-Dichloroamethopterin|3',5'-Dichloroamethopterin|3',5'-Dichloromethotrexate|3'-5'-Dichloromethotrexate|3,5-Dichloromethotrexate|Amethopterin, 3',5'-dichloro|Amethopterin, 3',5'-dichloro-|DCM|Dichloroamethopterin|Glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-|Glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-L- (8CI)|Glutamic acid, N-(3,5-dichloro-4-([(2, 4-diamino-6-pteridinyl)methyl]methylamino)benzoyl)-|Glutamic acid, N-[3,5-dichloro-4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-|Glutamic acid, N-[3,5-dichloro-4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, L- (8CI)|L-Glutamic Acid, N-{3,5-dichloro-4-{[(2,4-diamino-6-pteridinyl)methyl]methylamino}benzoyl}-(9CI)|L-Glutamic acid, N-[3,5-dichloro-4-[[(2, 4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]- (9CI)|Methotrexate, Dichloro|Methotrexate, dichloro-|N-[3,5-Dichloro-4-[(2, 4-diamino-6-pteridinylmethyl)methylamino]benzoyl]glutamic acid|N-[3,5-Dichloro-4-[(2,4-diamino-6-pteridinylmethyl)methylamino]benzoyl] Glutamic Acid|NSC 29630|NSC-29630	A chlorinated methotrexate derivative.  Dichloromethotrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylates and inhibiting DNA and RNA synthesis.  This agent is metabolized and excreted by the liver. (NCI04)
C967	Cordycepin_Triphosphate	Cordycepin	Cordycepin Triphosphate|3'-Deoxyadenosine-5'-(tetrahydrogen triphosphate)|Cordycepin-5'-triphosphate	The triphosphate salt of Cordycepin, a purine nucleoside antimetabolite analogue and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity. Cordycepin incorporates into RNA, and, inhibits RNA chain elongation and synthesis due to the absence of a hydroxyl moiety at the 3' position.  Because it is converted to an inactive metabolite by adenosine deaminase, this agent must be administered with an adenosine deaminase inhibitor in order to be effective.  Cordycepin has displayed cytotoxicity against some leukemic cell lines in vitro. (NCI04)
C968	Dezaguanine	Purine_Antagonist	Dezaguanine|3-Deazaguanine|CI-908|Deazaguanine|Deazaguanine Mesylate|Dezaguanine Mesylate	A purine nucleoside analogue with antineoplastic and antiviral activity.  By replacing guanine, dezaguanine incorporates into DNA and inhibits de novo purine synthesis, thereby inducing cell death. (NCI)
C969	Droloxifene	Selective_Estrogen_Receptor_Modulator	Droloxifene|(E)--1-[4'-(2-dimethylaminoethyoxy)phenyl]-1(3-hydroxyphenyl)-2-phenyl-but-1-ene|(E)-3-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol|(E)-alpha[p-[2-(dimethylamino)ethoxy]phenyl]-alpha'-ethyl-3-stilbenol|3-Hydroxytamoxifen	A phenolic analogue of tamoxifen, a nonsteroidal selective estrogen receptor modulator (SERM).  Droloxifene competitively inhibits the binding of estradiol to estrogen receptors, thereby preventing the receptor from binding to the estrogen-response element on DNA.  The result is a reduction in DNA synthesis and cellular response to estrogen. (NCI)
C970	Meta-Iodobenzylguanidine	Radioconjugate	Iodine I 131 Metaiodobenzylguanidine|131 I-MIBG|I 131 Meta-iodobenzylguanidine|I 131 Metaiodobenzylguanidine	An I 131 radioiodinated synthetic analogue of the neurotransmitter norepinephrine. Meta-iodobenzylguanidine localizes to adrenergic tissue and, in radioiodinated forms, may be used to image or eradicate tumor cells that take up and metabolize norepinephrine.
C971	_4_Iodo-4_Deoxydoxorubicin	Anthracycline_Antibiotic	4'-Iodo-4'-Deoxydoxorubicin|4'-Deoxy-4'-Iododoxorubicin|IDOX|Iodo-Doxorubicin|Iododoxorubicin|iododoxorubicin	A substance that is being studied as a treatment for cancer, and for primary systemic amyloidosis (a disease in which proteins are deposited in specific organs). It belongs to the family of drugs called anthracycline analogues.
C972	Deoxydoxorubicin	Anthracycline_Antibiotic	Deoxydoxorubicin|4'-Deoxyadriamycin|4'-Deoxyadriamycin Hydrochloride|4'-Deoxydoxorubicin|Deoxyadriamycin|Esorubicin|IMI-58	A synthetic derivative of the anthracycline antineoplastic antibiotic doxorubicin.  Deoxydoxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent exhibits less cardiotoxicity than the parent antibiotic doxorubicin, but may cause severe myelosuppression. (NCI04)
C973	Alendronate_Sodium	Biphosphonate	Alendronate Sodium|ALENDRONATE SODIUM|Adronat|Alendronate|Alendronic Acid Monosodium Salt Trihydrate|Alendros|Fosamax|G-704650|MK-217|Onclast|alendronate sodium	A bisphosphonate with increased antiresorption activity (100x-1000x that of etidronate).
C974	Formestane	Steroidal_Aromatase_Inhibitor	Formestane|4-Hydroxyandrost-4-ene-3,17-dione|4-Hydroxyandrostenedione|4-OHA|4-OHAD|CGP-32349|Lentaron	A synthetic steroidal substance with antineoplastic activity.  Formestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. (NCI04)
C975	_4-Hydroxy-Tamoxifen	Selective_Estrogen_Receptor_Modulator	4-Hydroxy-Tamoxifen	A tamoxifen metabolite with both estrogenic and anti-estrogenic effects.  4-hydroxytamoxifen has a higher affinity for the estrogen receptor than tamoxifen, and functions as an antagonist in breast cancer cells. (NCI04)
C976	Ipomeanol	Antineoplastic_Plant_Product|Miscellaneous_Alkylating_Agent	Ipomeanol|1-(3-Furanyl)-4-hydroxy-1-pentanone|1-(3-furanyl)-4-hydroxy-1-pentanone|1-Pentanone, 1-(3-furanyl)-4-hydroxy-|4-Ipomeanol|4-ipomeanol	A natural toxic furan isolated from a fungus-infected sweet potato (Ipomoea batatas) with potential antineoplastic activity.  Ipomeanol is activated by mixed function oxidases in vivo to its epoxide form, an alkylating agent that covalently binds cell macromolecules. This agent causes cell death by a p53-independent mechanism. (NCI04)
C977	_4-Nitroestrone_3-Methyl_Ether	Estrogen_Sulfotransferase_Inhibitor|Steroidal_Estrogen	4-Nitroestrone 3-Methyl Ether|4-Nitroestrone|4-Nitroestrone 3-methyl ether|Nitroestron Meth ETH	A synthetic derivative of estradiol. 4-nitroestrone 3-methyl ether inhibits estrogen sulfotransferase (EST), a progesterone-induced secretory endometrial enzyme which affects estrogen receptor levels.  This agent has been shown to be an effective growth inhibitor of some chemically induced animal mammary tumors. (NCI04)
C978	Doxifluridine	Pyrimidine_Antagonist	Doxifluridine|5'-Deoxy-5-fluorouridine|5-DFUR	An antimetabolite that is converted into 5-FU in the presence of pyrimidine nucleoside phosphorylase, interfering with DNA biosynthesis. (NCI)
C979	Lometrexol	Folate_Antagonist|Glycinamide_Ribonucleotide_Formyltransferase_Inhibitor	Lometrexol|(6R)-DDATHF|6R-5,10-Dideazatetrahydrofolate|L-Glutamic acid, N-(4-(2-((6R)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-|L-Glutamic acid, N-(4-(2-(2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)benzoyl)-, (R)-|lometrexol	A folate analog antimetabolite with antineoplastic activity. As the 6R diastereomer of 5,10-dideazatetrahydrofolate, lometrexol inhibits glycinamide ribonucleotide formyltransferase (GARFT), the enzyme that catalyzes the first step in the de novo purine biosynthetic pathway, thereby inhibiting DNA synthesis, arresting cells in the S phase of the cell cycle, and inhibiting tumor cell proliferation.  The agent has been shown to be active against tumors that are resistant to the folate antagonist methotrexate. (NCI04)
C980	Dihydro-5-Azacytidine	Pyrimidine_Antagonist	Dihydro-5-Azacytidine|1,3,5-triazin-2(1H)-one, 4-amino-3, 6-dihydro-1-beta-D-ribofuranosyl monohydrochloride|5,6-Dihydro-5-azacytidine hydrochloride|5,6-dihydro-5-azacytidine HCl|5,6-dihydro-5-azacytidine hydrochloride|DHAC	A synthetic nucleoside analogue of deoxycytidine. Dihydro-5-azacytidine inhibits DNA methyltransferase, thereby interfering with abnormal DNA methylation patterns that are associated with genetic instability in some tumor cells. Inhibition of this enzyme may restore expression of tumor-suppressor genes and result in antitumor activity. (NCI04)
C981	Decitabine	DNA_Methyltransferase_Inhibitor|Pyrimidine_Antagonist	Decitabine|2'-Deoxy-5-azacytidine|4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1,3,5-triazin-2(1H)-one|5-Aza-2'-deoxycytidine|5-Aza-2'deoxycytidine/Decitabine|5-Aza-2-deoxycytidine|5-Azadeoxycytidine|DAC|Deoxyazacytidine|Dezocitidine|decitabine	A cytidine antimetabolite analogue with potential antineoplastic activity. Decitabine incorporates into DNA and inhibits DNA methyltransferase, resulting in hypomethylation of DNA and intra-S-phase arrest of DNA replication. (NCI04)
C982	Chloroquinoxaline_Sulfonamide	Topoisomerase-II_Inhibitor	Chloroquinoxaline Sulfonamide|Benzenesulfonamide, 4-amino-N-(5-chloro-2-quinoxalinyl)-|Benzenesulfonamide, 4-amino-N-[5-chloro-2-quinoxalinyl]-|CQS|Chloroquinoxaline sulfonamide|Chlorsulfaquinoxaline|chloroquinoxaline sulfonamide|chlorosulfaquinoxaline	A chlorinated heterocyclic sulfanilamide with potential antineoplastic activity and potential immunosuppressive activity.  Chloroquinoxaline sulfonamide poisons topoisomerase II alpha and topoisomerase II beta, thereby causing double-stranded breaks in DNA, accumulation of unrepaired DNA, and apoptosis.  This agent also exhibits lymphotoxicity by inhibiting lymphocyte activation in a cell cycle-specific manner. (NCI04)
C983	Acarbose	Glucosidase_Inhibitor|Miscellaneous_Chemoprotective_Agent	Acarbose|Bay g 5421|O-4,6-Dideoxy-4-[[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)-2-cyclohexen-1-yl]amino]-alpha-D-glucopyranosyl-(1-4)-O-alpha-D-glucopyranosyl-(1-4)-D-glucose	An orally administered inhibitor of alpha glucosidase that decreases the digestion and absorption of carbohydrates in the small intestine and leads to decreased blood glucose levels after a carbohydrate load. (NCI)
C984	Aceglatone	Glucuronidase_Inhibitor	Aceglatone	A B-glucuronidase inhibitor which may act as a chemopreventive agent in colon carcinogenesis. (NCI)
C985	Acitretin	Retinoic_Acid_Agent	Acitretin|(All-E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid|ACITRETIN|Etretin|Neotigason|Ro 10-1670|Ro-10-1670|Soriatane|Trimethylmethoxyphenyl-retinoic acid|acitretin	A drug used in cancer prevention that belongs to the family of drugs called retinoids. It is also used in the treatment of psoriasis.
C986	Acivicin	Glutamine_Amidotransferase_Inhibitor|Purine_Antagonist	Acivicin|AT-125|U-42126	A modified amino acid and structural analog of glutamine.  Acivicin inhibits glutamine amidotransferases in the purine and pyrimidine biosynthetic pathways, thereby inhibiting tumor growth in cell lines dependent on glutamine metabolism. (NCI04)
C987	Aclacinomycin_Antibiotic	Anthracycline_Antibiotic	Aclacinomycin Antibiotic|Aclacinomycins	A class of antineoplastic oligosaccharide anthracycline antibiotics isolated from various strains of the bacterium Streptomyces galilaeus.  These agents display potent antitumor properties due to their ability to intercalate into DNA and inhibit topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)
C988	Acodazole	Intercalating_Agent	Acodazole|1H-imidazo[4,5-f]quinoline, acetamide deriv|Acetamide, N-methyl-N-[4-[(7-methyl-1H-imidazo[4, 5-f]quinolin-9-yl)amino]phenyl]-, monohydrochloride (9CI)|Acodazole HCl|Acodazole Hydrochloride|acetamide, N-methyl-N-[4-[(7-methyl-1H-imidazo[4, 5-f]quinolin-9-yl)amino]phenyl]-, monohydrochloride (9CI)	A synthetic imidazoquinoline with antineoplastic activity. Acodazole intercalates into DNA, resulting in disruption of DNA replication.  Use of this agent has been associated with significant cardiotoxicity. (NCI04)
C989	Recombinant_Activin	Therapeutic_Transforming_Growth_Factor-Beta_1	Recombinant Activin|Activin	Dimeric growth factors of the TGF family with effects on a range of cell types in addition to promoting FSH release in gonadal sites. Composed of two of the subunits of inhibin, the isoforms A and B.
C990	Corynebacterium_Granulosum_P40	Chemo_Immunostimulant_Adjuvant	Corynebacterium Granulosum P40|Adjuvant P40	An insoluble fraction isolated from the bacterium Corynebacterium granulosum with potential cancer immunotherapeutic activity.  As a non-specific immunostimulant, Corynebacterium granulosum P40 activates the reticulo-endothelial system, induces the production of certain cytokines, enhances macrophage activity, and potentiates a delayed-type hypersensitivity response when co-administered with an antigen. (NCI04)
C991	Recombinant_ATL_Derived_Factor	Therapeutic_Cytokine	Recombinant ATL Derived Factor	Adult T-cell Leukemia derived factor: Human thioredoxin. A cytokine.
C992	Monobenzone	Hydrocarbon	Monobenzone|Hydroquinone monobenzyl ether|MONOBENZONE|Monobenzyl ether hydroquinone|monobenzyl ether of hydroquinone	A monobenzyl ether of hydroquinone that destroys melanocytes and causes permanent depigmentation of the skin. The exact mechanism of action is unknown. (NCI)
C993	AL721	Miscellaneous_Antiviral_Agent	AL721|AL-721|Egg Lecithin Lipids	A mixture of neutral lipids (70%), phosphatidylcholine (20%) and phosphatidylethanolamine (10%), AL721 removes cholesterol from outer cell membranes, increases membrane fluidity, and impairs virus attachment to cell receptors. AL721 is potentially useful (and in study) for diseases where membrane fluidity plays a role (cancers, cystic fibrosis). (NCI04)
C994	L-Alanosine	Adenylosuccinate_Synthetase_Inhibitor|Miscellaneous_Antineoplastic_Antibiotic|Purine_Antagonist	L-Alanosine|3-(Hydroxynitrosoamino)-L-alanine|ALANOSINE|Alanosine|L-2-Amino-3-(hydroxynitrosoamino)propionic Acid|L-2-Amino-3-[(N-nitroso)hydroxylamino]propionic Acid|L-2-Amino-3-[(N-nitroso)hydroxylamino]propionic acid|L-Alanosine Sodium|salt	An amino acid analog derived from Streptomyces alanosinicus, a purine antagonist, and an adenylosuccinate synthetase inhibitor with antineoplastic properties. L-alanosine deprives MTAP-deficient (salvage pathway) tumor cells of de novo synthesized adenosine and is probably responsible for diminished DNA synthesis. The clinical use of L-alanosine may be narrow due to its toxicity profile. (NCI04)
C995	Alizapride	Antiemetic_Agent	Alizapride	A substituted benzamide that acts as a dopamine receptor antagonist with antiemetic properties. (NCI)
C996	Allocolchicine	Tubulin_Binding_Agent	Allocolchicine	An antimitotic agent that binds to tubulin and inhibits tubulin polymerization and arrests proliferation of tumor cells. (NCI)
C997	Alpha-Linolenic_Acid	Omega-3_Fatty_Acid	Alpha-Linolenic Acid|.alpha.-Linolenic acid|ALA	An essential fatty acid belonging to the omega-3 fatty acids group. It is highly concentrated in certain plant oils and has been reported to inhibit the synthesis of prostaglandin resulting in reduced inflammation and prevention of certain chronic diseases.(NCI)
C998	Metyrosine	Tyrosine_Hydroxylase_Inhibitor	Metyrosine|Alpha-methyl-p-tyrosine|Demser|L-588357-0|METYROSINE|MK-781|Metirosine|methyl-tyrosine
C999	Amonafide	Intercalating_Agent|Topoisomerase-II_Inhibitor	Amonafide|1H-benz(de)isoquinoline-1,3(2H)-dione, 5-amino-2-(2-(dimethylamino)ethyl)|Amonafide Hydrochloride|BIDA|Benzisoquinolinedione|M-FA-142|Nafidimide	An imide derivative of naphthalic acid.  Amonafide intercalates into DNA and inhibits topoisomerase II, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis. (NCI04)
C1000	Recombinant_Amphiregulin	Therapeutic_Epidermal_Growth_Factor	Recombinant Amphiregulin|AR|CRDGF|KAF	A recombinant form of amphiregulin, a member of the heparin-binding epidermal growth factor (EGF) family. Endogenous amphiregulin is an autocrine growth factor, and binds to the EGF receptor. Overexpressed in several cancer cell types, endogenous amphiregulin may contribute to tumor cell proliferation and metastasis. (NCI04)
C1001	Atvogen	Immunostimulant	Atvogen|Ampligen|Poly(I).Poly(c12,U)|Poly(Inosinic Acid) Poly(Cytidylic(12), Uridylic)Acid	A synthetic derivative of inosinic acid with antiretroviral and immunomodulatory properties.  Atvogen acts through a number of pathways to stimulate intracellular antiviral activity of the immune system: it stimulates interferon production; activates the oligoadenylate synthetase RNase L pathway; stimulates natural killer cell activity; and acts as a nonmitogenic stimulator of the immune system. This agent also inhibits replication of human immunodeficiency virus (HIV) in vitro. (NCI04)
C1002	Recombinant_Angiogenin	Therapeutic_Growth_Factor	Recombinant Angiogenin	A 14kD non-glycosylated human derived angiogenesis factor, which has the ability to induce neovascularisation with a unique ribonucleolytic activity. (NCI)
C1003	Ansamycin_Antineoplastic_Antibiotic	Antineoplastic_Antibiotic	Ansamycin Antineoplastic Antibiotic|Ansamycin Antibiotics|Ansamycins|ansamycins	A group of anticancer drugs that belongs to the family of drugs called antineoplastic antibiotics.
C1004	Antineoplaston_A10	Antineoplaston_Agent	Antineoplaston A10|3-Phenylacetylamino-2, 6-piperidinedione|3-Phenylacetylamino-2,6-piperidinedione	A piperidinedione antineoplaston with potential antineoplastic activity.  Antineoplaston A10 was originally isolated from human urine but is now synthetically derived.  This agent intercalates into DNA, resulting in cell cycle arrest in G1 phase, reduction of mitosis, and decreased protein synthesis.  Antineoplaston A10 may also inhibit ras-oncogene expression and activate tumor suppressor gene p53, leading to cell differentiation and apoptosis. (NCI04)
C1005	Arsenic_Trioxide	Differentiation_Inducer	Arsenic Trioxide|ARSENIC TRIOXIDE|Arsenic (III) Oxide|Arsenic Sesquioxide|Arsenic Trioxide (Trisenox)|Arsenous Acid|Arsenous Acid Anhydride|Arsenous Oxide|Trisenox|White Arsenic|arsenic trioxide	A small-molecule arsenic compound with antineoplastic activity.  The mechanism of action of arsenic trioxide is not completely understood. This agent causes damage to or degradation of the promyelocytic leukemia protein/retinoic acid receptor-alpha (PML/RARa) fusion protein; induces apoptosis in acute promyelocytic leukemia (APL) cells and in many other tumor cell types; promotes cell differentiation and suppresses cell proliferation in many different tumor cell types; and is pro-angiogenic. (NCI04)
C1006	Ossirene	Immunostimulant	Ossirene|AS 101|AS-101|AS101|IVX-Q-101	A synthetic ammonium trichloro-tellurate derivative with potential immunomodulatory and antiparasitic properties.  Ossirene may increase cell proliferation, cytokine secretion, and the production of nitric oxide, and may activate neutrophils and macrophages. This agent has been studied as a possible treatment for babesiosis, a tick-transmitted parasitic disease. (NCI04)
C1007	Azapicyl	Unclassified_Chemotherapy_Agent	Azapicyl|1-Acetyl-2-picolinoylhydrazine|1-acetyl-2-picolinoylhydrazine|2-acetylhydrazide-2-pyridinecarboxylic acid|Azapicol|NSC 68626|NSC-68626|P-2292	A hydrazine compound that has been investigated for antineoplastic activity. (NCI04)
C1008	Azauridine_Triacetate	Orotidylate_Decarboxylase_Inhibitor|Pyrimidine_Antagonist	Azauridine Triacetate|2',3',4'-azauridine triacetate|2-(2,3,5-Tri-O-acetyl-beta-D-ribofuranosyl)-as-triazine-3,5(2H,4H)-dione|6-Azauridine Triacetate|6-Azauridine triacetate|Azaribine|Azauridine triacetate|CB 304|SKI 28426|Triacetyl 6-azauridine|Triacetyl 6-azuridine|Triacetyl-6-azauridine|Triacetyl-6-azuridine|Triazure	A drug used in the treatment of psoriasis.
C1009	Ethylenimine	Ethylenimine_Compound	Ethylenimine|Aminoethylene|Azacyclopropane|Azirane|Aziridine|Dimethyleneimine|Dimethylenimine|Ethyleneimine|Ethylimine	A monofunctional alkylating agent with potential antineoplastic activity.  Reacting with DNA mainly at guanine and adenine residues, ethylenimine alkylates DNA, thereby producing DNA interstrand crosslinks and DNA breaks, and interfering with DNA replication and cell division. (NCI04)
C1010	Nafazatrom	Cardioprotective_Agent|Lipooxygenase_Inhibitor	Nafazatrom|1-(2-(beta-naphthyloxy)ethyl)-3-methyl-2-pyrazolin-5-one|3H-pyrazol-3-one,2,4-dihydro-5-methyl-2-(2-(2-naphthalenyloxy)ethyl|Bay g 6575|Bay-g 6575	An antithrombotic and antimetastatic agent having a pyrazolone functionality that inhibits peroxidation of phosphatidylcholine liposomes, heart homogenate, and low-density lipoproteins. (NCI)
C1011	Beauvericin	Depsipeptide_Antibiotic|Immunosuppressant	Beauvericin	A cyclic hexadepsipeptide antibiotic and mycotoxin isolated from the fungus Beauveria bassiana and various Fusarium fungal species.  As a potassium-specific ionophore, beauvericin A increases intracellular calcium concentrations and triggers DNA fragmentation and apoptosis through a calcium dependent caspase 3-sensitive pathway.  This agent has been studied as a potential antineoplastic agent. (NCI04)
C1012	Benzodiazepine	Antiemetic_Agent|Anxiolytic	Benzodiazepine	Drugs from this chemical class are used for their central nervous system depressant properties including sedation, facilitation of sleep, seizure control, general anesthesia, anxiolytic, amnestic, and for detoxification from similar (cross tolerant) drugs
C1013	Benznidazole	Antiprotozoal_Agent	Benznidazole|2-Nitro-N-(phenylmethyl)-1H-imidazole-1-acetamide|N-Benzyl-2-nitroimidazole-1-acetamide|N-benzyl-2-nitroimidazole-1-acetamide|Radanil|Ro-7-1051	A nitroimidazole derivative having an antiprotozoal activity by interfering with parasite protein biosynthesis, influencing cytokines production and stimulating host phagocytosis. (NCI)
C1014	Verteporfin	Hematoporphyrin_Derivative	Verteporfin|BPD-MA|Benzoporphyrin Derivative Monoacid Ring A|Visudyne	A synthetic light-activated agent with photodynamic activity. Upon systemic administration, verteporfin accumulates in neovessels in the eye and, once stimulated by nonthermal red light in the presence of oxygen, produces highly reactive short-lived singlet oxygen and other reactive oxygen radicals, resulting in local damage to neovascular endothelium and blood vessel occlusion. (NCI04)
C1015	Ubenimex	Immunostimulant|Vaccine_Adjuvant	Ubenimex|Bestatin|L-Leucine, N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-, [S-(R*,S*)]-|N-[(2S,3R)-4-phenyl-3-amino-2-hydroxybutyryl]-L-leucine|NK 421|[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine|[S-(R*,S*)]-N-(3-amino-2-hydroxy-1-oxo-4-phenylbutyl)-L-leucine	An aminopeptidase B and leucine aminopeptidase inhibitor.  A biological response modifier that exhibits direct antileukemic effects against human leukemic cell lines through the induction of apoptosis.
C1016	Beta_Carotene	Carotenoid|Nutritional_Supplement	Beta Carotene|.beta.-Carotene|CAROTENE, BETA|Solatene|beta carotene|beta-Carotene	A naturally-occurring retinol (vitamin A) precursor obtained from certain fruits and vegetables with potential antineoplastic and chemopreventive activities.  As an anti-oxidant, beta carotene inhibits free-radical damage to DNA.  This agent also induces cell differentiation and apoptosis of some tumor cell types, particularly in early stages of tumorigenesis, and enhances immune system activity by stimulating the release of natural killer cells, lymphocytes, and monocytes. (NCI04)
C1017	Glucuronidase_Inhibitor	Enzyme_Inhibitor	Glucuronidase Inhibitor|beta-D-Glucuronidase Inhibitors|beta-Glucuronidase Inhibitors	A chemopreventive compound that inhibits beta-glucuronidase and prevents hydrolysis of their glucuronides. Examples are calcium D-glucarate and saccharolactone. (NCI)
C1018	Klebsiella_pneumoniae_Glycoprotein	Immunostimulant	Klebsiella pneumoniae Glycoprotein|Biostim|RU 41740	An immunostimulant glycoprotein extracted from Klebsiella pneumoniae.
C1019	Bisantrene	Anthraquinone_Compound	Bisantrene|9,10,Anthracenedicarboxaldehyde|9,10-Anthracenedicarboxakdehyde Bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone]|9,10-Anthracenedicarboxaldehyde Bis(2-imidazolin-2-yl)hydrazone|ADAH|ADCA|Bisantrene Dihydrochloride|Bisantrene HCL|Bisantrene HCl|Bisantrene Hydrochloride|CL 216942|CL-216942|NSC 337766|Orange Crush|Zantrene	An anthracenyl bishydrazone with antineoplastic activity. Bisantrene intercalates with and disrupts the configuration of DNA, resulting in DNA single-strand breaks, DNA-protein crosslinking, and inhibition of DNA replication.  This agent is similar to doxorubicin in activity, but unlike doxorubicin, does not exhibit cardiotoxicity. (NCI04)
C1020	Bismuth_Subsalicylate	Antidiarrheal_Agent|Cytoprotective_Agent	Bismuth Subsalicylate|BISMUTH SUBSALICYLATE|Pepto-Bismol	A bismuth salt of salicylic acid.  Little absorbed from the gastrointestinal tract, bismuth subsalicylate exerts a local effect on the gastric mucosa, coating it and protecting it from the corrosive effects of acid and pepsin.  This agent also has local antimicrobial properties. (NCI04)
C1021	Batanopride	Antiemetic_Agent	Batanopride|BMY-25801	A serotonin antagonist having antiemetic properties. (NCI)
C1022	Emitefur	Pyrimidine_Antagonist	Emitefur|(2) m-[[3-(Ethoxymethyl)-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]carbonyl]benzoic Acid, 2-Ester with 2,6-Dihydroxynicotinonitrile Benzoate (Ester)|3-[3-(6-Benzoyloxy-3-cyrano-2-pyridyloxycarbonyl)benzoyl]-1-(ethoxymethyl)-5-fluorouracil|3-[[3-(Ethoxymethyl)-5-fluoro-3.6-dihydro-2,6-dioxo-1(2H0-pyrimidinyl]carbonyl]benzoic Acid 6-(Benzoyloxy)-3-cyano-2-pyridinyl Ester|BOF-A2|Ethoxymethyl-5-fluoro-3,6-dihydro-2,6-dioxo-1(2H)-pyrimidinyl]carbonyl]benzoic Acid, 6-(Benzoyloxy)-3-cyano-2-pyridinyl Ester|Last-F|emitefur	An anticancer drug that belongs to the family of drugs called antimetabolites.
C1023	Amoxicillin-Clavulanate_Potassium	Amoxicillin-Clavulanic_Acid	Amoxicillin-Clavulanate Potassium|Amoxicillin/Clavulanate Potassium|Augmentin	A combination of the semisynthetic broad-spectrum antibiotic amoxicillin and the beta-lactamase enzyme inhibitor clavulanate potassium. Clavulanate potassium increases the serum half-life of amoxicillin by inhibiting beta-lactamase-mediated metabolism of amoxicillin.  Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin binding proteins and inhibiting peptidoglycan synthesis, a critical component of bacterial cell walls.
C1024	Bropirimine	Immunostimulant	Bropirimine|2-Amino-5-bromo-6-phenyl-4(3H)-pyrimidone|2-amino-5-bromo-6-phenyl-4-(3H)-pyrimidinone|4(3H)-Pyrimidinone, 2-amino-5-bromo-6-phenyl-|4-Pyrimidinol, 2-amino-5-bromo-6-phenyl-|ABPP|Remisar|U-54,461	An oral immunostimulant that causes the body to produce interferon and other substances.
C1025	Bruceantin	Miscellaneous_Antineoplastic_Antibiotic|Quassinoid_Agent	Bruceantin|2H-3, 11c-(Epoxymethano)phenanthro[10,1-bc]pyran, Picras-3-en-21-oic Acid Derivative|BRUCEANTIN|NSC 165563|Picras-3-en-21-oic Acid, 15-[(3,4-dimethyl-1-oxo-2-pentenyl)oxy]-13,20-epoxy-3,11, 12-trihydroxy-2,16-dioxo-, Methyl Ester, (11.beta.,12.alpha,15.beta.(E))|Picras-3-en-21-oic acid, 15-[(3, 4-dimethyl-1-oxo-2-pentenyl)oxy]-13,20-epoxy-3,11,12-trihydroxy-2, 16-dioxo-, methyl ester [11.beta.,12.alpha.,15.beta.(E]-|Picras-3-en-21-oic acid, 15-[(3, 4-dimethyl-1-oxo-2-pentenyl)oxy]-13,20-epoxy-3,11,12-trihydroxy-2, 16-dioxo-, methyl ester, [11.beta.,12.alpha.,15.beta.(E)]-|[11Beta,12alpha,15beta(E)]-15-[(3,4-dimethyl-1-oxo-2-pentenyl)oxy]-13,20-epoxy-3,11,12-trihydroxy-2,16-dioxopicras-3-en-21-oic Acid Methyl Ester	A triterpene quassinoid antineoplastic antibiotic isolated from the plant Brucea antidysenterica.  Bruceantin inhibits the peptidyl transferase elongation reaction, resulting in decreased protein and DNA synthesis.  Bruceantin also has antiamoebic and antimalarial activity. (NCI04)
C1026	Bryostatin-1	Immunostimulant|Protein_Kinase_C_Inhibitor	Bryostatin-1|B705008K112|Bryostatin|Bryostatin 1|Bryostatin I|bryostatin 1	A drug used for its antitumor activity.
C1027	Budesonide	Therapeutic_Glucocorticoid	Budesonide|(RS)-11beta,16alpha,17,21,-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal w/ butyraldehyde|(RS)-11beta,16alpha,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal w/ butyraldehyde|Budecort|Butacort|Eltair|Nasocort|Preferid|Pregna-1,4-diene-3,20-dione,16,17-(butylidenebis(oxy))-11,21-dihydroxy-, (11beta,16alpha)-|Pulmicort|Pulmicort Turbuhaler|Rhinocort|budesonide	(try-am-SIN-oh-lone) A substance that is being studied for the prevention of nonmelanoma skin cancer.  It is an anti-inflammatory drug that is applied to the skin to relieve irritation, rashes, and infections.  It belongs to the family of drugs called topical corticosteroids.
C1028	Butein	Tyrosine_Kinase_Inhibitor	Butein|2',3,4,4'-Tetrahydroxy-chalcone	A flavonoid obtained from the seed of Cyclopia subternata. It is a specific protein tyrosine kinase inhibitor that induces apoptosis. (NCI)
C1029	Buthionine_Sulfoximine	Gamma-Glutamylcysteine_Synthetase_Inhibitor|Multidrug_Resistance_Modulator	Buthionine Sulfoximine|2-Amino-4-(S-butylsulfonimidoyl) Butanoic Acid|BSO|Butanoic Acid, 2-Amino-4-(S-butylsulfonimidoyl)-|Butanoic acid, 2-amino-4-(S-butylsulfonimidoyl)-|Buthionine Sulphoximine|L-Buthionine Sulfoximine|L-Buthionine sulfoximine|S-(3-Amino-3-carboxypropyl)-S-butylsulfoximine|S-(n-Butyl)homocysteine Sulfoximine|buthionine sulfoximine|d,l-Buthionine-s,r-sulfoximine	A drug that may help prevent resistance to some anticancer drugs.
C1030	Butocin	Therapeutic_Oxytocin	Butocin|Benin|Butocine|N-(5-(6-purinylthio)valeryl)glycine ethyl ester|benin|benin spofa|butocine	A synthetic oxytocin, for injection.
C1031	Piritrexim	Dihydrofolate_Reductase_Inhibitor|Folate_Antagonist	Piritrexim|2,4-Diamino-6-(2,5-dimethoxybenzyl)-5-methylpyrido[2,3-d]pyrimidine|6-((2,5-Dimethoxyphenyl)methyl)-5-methylpyrido(2,3-d)pyrimidine-2,4-diamine|6-[(2,5-Dimethoxyphenyl)methyl]-5-methylpyrido[2,3-d]pyrimidine-2,4-diamine|BW 301U|BW-301U|Piritrexim Isethionate|Piritrexim isethionate|piritrexim	A synthetic antifolate agent with antiparasitic, antipsoriatic and antitumor properties. Piritrexim inhibits the enzyme dihydrofolate reductase enzyme, thereby disrupting folate metabolism and DNA synthesis and cell division. (NCI04)
C1032	Cactinomycin	Actinomycin_Antibiotic	Cactinomycin|ACTINOMYCIN C|Actinomycin C	A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces chrysomallus.  Cactinomycin binds to DNA by intercalating between guanine and cytosine, forming stable antibiotic-DNA complexes that inhibit RNA and protein synthesis. (NCI04)
C1033	Citrated_Caffeine	Caffeine	Citrated Caffeine|Caffeina Citrata|Caffeine Citrate	Commercial citrate of caffeine, though not a definite salt.  It is the alkaloid caffeine, with a portion of adherent citric acid, as indicated by its pharmacopoeial. name (citrated caffeine). Its general action and uses are the same as those given under caffeine. Citrated caffeine is used chiefly as a remedy for the idiopathic headache (migraine). This salt is very soluble in water, and is assimilated much more readily than pure caffeine when taken into the stomach. (NCI04)
C1034	Heparin_Calcium	Heparin	Heparin Calcium|Calciparine	The calcium salt form of heparin.  As a glycosaminoglycan anticoagulant, heparin calcium binds to antithrombin III to form a heparin-antithrombin III complex. The complex binds to and irreversibly inactivates thrombin and other activated clotting factors IX, X, XI, and XII and prevents the transformation of fibrinogen to fibrin. (NCI)
C1035	Calicheamicin_Gamma_1I	Enediyne_Antitumor_Antibiotic	Calicheamicin Gamma 1I	An oligosaccharide enediyne antitumor antibiotic isolated from Micromonospora echinospora ssp. Calichensis.  Calicheamicin Gamma 1I binds to the minor groove of DNA, resulting in site-specific double-strand breaks and apoptosis. (NCI04)
C1036	Canola_Oil	Food_Oil	Canola Oil	Vegetable oil developed from rapeseed plant. (NCI)
C1037	Caracemide	Miscellaneous_Antimetabolite|Ribonucleotide_Reductase_Inhibitor	Caracemide|Acetamide, N-[(Methylamino)carbonyl]-N-[[(methylamino)carbonyl]oxy]-(9CI)|Acetamide, N-[(methylamino)carbonyl]-N-[[(methylamino)carbonyl]oxy]- (9CI)|N-Acetyl-N-(methylcarbamoyloxy)-N'-methylurea	An agent derived from acetohydroxamic acid with potential antineoplastic activity.  Caracemide inhibits ribonuclease reductase, resulting in decreased DNA synthesis and tumor growth; it also inhibits acetylcholinesterase.  In vivo, caracemide contributes to the formation of the neurotoxin methyl isocyanate; this effect, along with the agent's acetylcholinesterase activity, may be responsible for the severe central nervous system toxicity observed in clinical trials. (NCI04)
C1038	Carbogen	Bioreductive_Agent|Radiosensitizing_Agent	Carbogen|carbogen	An inhalant consisting of hyperoxic gas (95%-98% oxygen and 2%-5% carbon dioxide) with radiosensitizing properties.  Inhaled carbogen reduces diffusion-limited tumor hypoxia, increasing tumor radiosensitivity due to the increased availability of molecular oxygen for cytotoxic radiation-induced oxygen free radical production. (NCI04)
C1039	Carbovir	Anti-HIV_Agent|Reverse_Transcriptase_Inhibitor	Carbovir|(+ -)-Carbovir	An anti-HIV agent that exerts its effects by inhibiting reverse transcriptase.
C1040	Carzinophilin	Ethylenimine_Compound|Miscellaneous_Antineoplastic_Antibiotic	Carzinophilin|CARZINOPHILIN|CZP|Cardinophillin|Cardinophyllin|Carzinophyllin	An ethylenimine antineoplastic antibiotic isolated from the bacterium Streptomyces sahachiroi.  Carzinophilin forms interstrand DNA cross-links, thereby inhibiting DNA synthesis. (NCI04)
C1041	Cefepime	Cephalosporin_Antibiotic	Cefepime|Maxipime|Pyrrolidinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methyl-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-|cefepime	A drug used to treat infection.  It belongs to the family of drugs called cephalosporin antibiotics.
C1042	Cetirizine	Histamine-1_Receptor_Antagonist	Cetirizine	Cetirizine is a metabolite of hydroxyzine and a selective peripheral histamine H1-receptor antagonist. It is used for symptomatic treatment of seasonal and perennial allergic rhinitis and for chronic urticaria. (NCI)
C1043	CGP-6809	Nitrosourea_Compound	CGP-6809|6-deoxy-3,5 di-O-methyl 6-(3-methyl-3-nitrosoureido)-alpha-D-glucofuranoside|EDMN|ethyl-6-deoxy-3,5-di-O-methyl-6-(3-methyl-3-nitrosoureido)-alpha-D-glucofuranoside]	A water-soluble nitrosourea that cross-links with DNA, causing inhibition of DNA synthesis.
C1044	Fadrozole_Hydrochloride	Non-Steroidal_Aromatase_Inhibitor	Fadrozole Hydrochloride|4-(5,6,7,8-Tetrahydroimidazo(1,5-a)pyridin-5-yl)benzonitrile|4-(5,6,7,8-Tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile Monohydrochloride|Afema|Arensin|CGS-16949A|Fadrozole	A non-steroidal aromatase inhibitor effective in the treatment of estrogen-dependent disease.
C1045	Chamomile	Miscellaneous_Chemoprotective_Agent	Chamomile	The flower-heads of either the plant Anthemis nobilis or the plant Matricaria chamomilla.  Chamomile has a warm aromatic odour and a very bitter taste and contains volatile oils which are a mixture of butyl and amyl angelates and valerates.  Due to its coumarin constituents, large doses may interfere with coagulation. (NCI04)
C1046	Chaparrinone	Quassinoid_Agent	Chaparrinone|Picras-3-ene-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1beta,11beta,12alpha)-	A quassinoid phytochemical isolated from Ailanthus integrifolia sp. calycina and other plant species with potential antineoplastic activity.  Chaparrinone inhibits protein synthesis, has antimalarial properties, and is cytotoxic to some tumor cells. (NCI04)
C1047	Chlornaphazine	Nitrogen_Mustard_Compound	Chlornaphazine	An alkylating antineoplastic agent no longer used in the United States, because it induces chromosomal aberration and causes cancer. (NCI)
C1048	Chloroaluminum_Phthalocyanine	Photosensitizing_Agent	Chloroaluminum Phthalocyanine|AlSPc|Aluminum Sulfonated Phthalocyanine|Non-Sulfonated Chloroaluminum Phthalocyanine|Sulfonated Aluminum Phthalocyanine	A rhodamine-based dye used as a photosensitizing agent in cytotoxic photodynamic therapy. (NCI)
C1049	Chlorozotocin	Nitrosourea_Compound	Chlorozotocin|1-(2-chloroethyl)-1-nitroso-3-(D-glucos-2-yl)urea|2-[3-(2-chloroethyl)-3-nitrosoureido]-2-deoxy-D-glucopyranose|2-[[[(2-chloroethyl)nitrosamino]carbonyl]amino]-2-deoxy-D-glucose|CZT|Chlorozotocyna|D-Glucopyranose|D-Glucopyranose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy-|D-Glucose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy- (9CI)|D-glucopyranose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy|D-glucose, 2-[[[(2-chloroethyl)nitrosoamino]carbonyl]amino]-2-deoxy- (9CI)|DCNU|NSC 178248	A glucose-linked chloroethylnitrosourea with potential antineoplastic activity.  Chlorozotocin alkylates DNA and proteins, induces the formation of interstrand DNA and DNA-protein crosslinks, and causes DNA strand breakage, thereby damaging DNA and resulting in cell death.  This agent has been shown to exhibit antitumor and immunomodulatory effects in cell lines and animal models.  Chlorozotocin is a mutagen and is less myelotoxic than other nitrosoureas. (NCI04)
C1050	CI-921	Topoisomerase-II_Inhibitor	CI-921|4-Acridinecarboxamide,9-((2-methoxy-4-((methylsulfonyl)amino)phenyl)amino-N,5-dimethyl|Amsalog	A synthetic derivative of acridine carboxamide with antineoplastic properties.  CI-921, a lipophilic and water-soluble analog of amsacrine, inhibits the enzyme topoisomerase ll, thereby blocking DNA replication and RNA and protein synthesis. (NCI04)
C1051	Cilostazol	Antiplatelet_Agent|Phosphodiesterase_Inhibitor	Cilostazol|CILOSTAZOL|Pletal	A quinolinone derivative, 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone, cellular phosphodiesterase inhibitor, more specific for phosphodiesterase III. Cilostazol is approved by FDA for the reduction of symptoms of intermittent claudication. The mechanism of the action is not fully understood. The agent and its metabolites suppress cAMP degradation with a resultant increase in cAMP in platelets and blood vessels, leading to inhibition of platelet aggregation and vasodilation. These actions may contribute to its effect, but other drugs with those properties are not known to be useful in intermittent claudication. Cilostazol is contraindicated for patients with congestive heart failure. Concomitant use with clopidogrel must be studied. (NCI)
C1052	CL_246738	Immunostimulant	CL 246738|3,6-bis-(2-piperidinoethoxyl)acridine trihydrochloride|CL 246,738	An immunomodulator, 3,6-bis(2-piperidinoethoxy) acridine trihydrochloride, used in a phase I study for possible immunostimulatory effects in colorectal cancer. (NCI)
C1053	Zeniplatin	Platinum_Compound	Zeniplatin|CL 286,558	A third-generation, water-soluble platinum compound. (NCI)
C1054	Clarithromycin	Macrolide_Antibiotic	Clarithromycin|6-O-Methylerythromycin|Abbott-56268|Biaxin|CLARITHROMYCIN|clarithromycin	A semisynthetic 14-membered ring macrolide antibiotic.  Clarithromycin binds to the 50S ribosomal subunit and inhibits RNA-dependent protein synthesis in susceptible organisms.  Clarithromycin has been shown to eradicate gastric MALT (mucosa-associated lymphoid tissue) lymphomas, presumably due to the eradication of tumorigenic Helicobacter pylori infection. This agent also acts as a biological response modulator, possibly inhibiting angiogenesis and tumor growth through alterations in growth factor expression. (NCI04)
C1055	OGX-011	Mixed-Backbone_Oligonucleotide	OGX-011|Antisense Clusterin|Antisense TRPM-2|Antisense Testosterone-Repressed Prostate Message 2|TRPM-2 Antisense	A mixed-backbone antisense oligodeoxynucleotide with chemosensitizing properties.  OGX-011 inhibits testosterone-repressed prostate message-2 (TRPM-2). Administration of OGX-011 abrogates the anti-apoptotic effect of TRPM-2, thereby sensitizing cells to chemotherapy and resulting in tumor cell death. TRPM-2 is an anti-apoptotic clusterin that is overexpressed by prostate cancer cells and is associated with chemoresistance. (NCI04)
C1056	Copovithane	Immunostimulant	Copovithane|BAY I 7433|CPV	A synthetic polymer (copolymer of 1,3-bis(methylaminocarboxyl)-2-methylenepropanecarbamate and N-vinyl pyrrolidone) of low molecular weight which acts as a nonspecific immune modulator and has been shown to have significant antitumor activity in vitro and in vivo in preclinical and some early clinical studies. The mechanism of action is unknown. Immunologic evaluation revealed some improvement in helper and suppressor T cell ratio, in vitro cytotoxicity tests, and lymphocyte blastogenic response. (NCI)
C1057	Cordycepin	Miscellaneous_Antineoplastic_Antibiotic|Purine_Antagonist	Cordycepin|3'-Deoxyadenosine|3'-Deoxyadenosine-5'-triphosphate|3'-dA-CE Phosphoramidite|3-dAdenosine|9-Cordyceposidoadenine|CORDYCEPIN|Cordycepine|Kordicepin|cordycepin	A purine nucleoside antimetabolite analogue and antibiotic isolated from the fungus Cordyceps militaris with potential antineoplastic activity. Cordycepin incorporates into RNA, and, inhibits RNA chain elongation and synthesis due to the absence of a hydroxyl moiety at the 3' position.  Because it is converted to an inactive metabolite by adenosine deaminase, this agent must be administered with an adenosine deaminase inhibitor in order to be effective.  Cordycepin has displayed cytotoxicity against some leukemic cell lines in vitro. (NCI04)
C1058	Cortisone_Acetate	Therapeutic_Cortisone	Cortisone Acetate|21-(Acetyloxy)-17-hydroxypregn-4-ene-3,11,20-trione|CORTISONE ACETATE|Cortisone acetate|Cortogen|Cortone|Cortone Acetate|Cortone acetate	The acetate salt of Cortisone. (NCI)
C1059	Cyproterone_Acetate	Cyproterone	Cyproterone Acetate|3'H-Cyclopropa(1,2)pregna-1,4,6-triene-3,20-dione, 17-(Acetyloxy)-6-chloro-1,2-dihydro-, (1beta,2beta)-|6-Chloro-1b,2b-dihydro-17a-hydroxy-3'H-cyclopropa[1,2]pregna-1,4,6-triene-3,20-dione Acetate|Andro-Diane|Androcur|Chloro-6-hydroxy-17 Alpha Methylene-1 Alpha, 2 Alpha Pregnadiene-4,6 Dione-3, 20 Acetate|CyPat|Cyprone|Cyprostat|Cyproteronazetat|Cyproteroni Acetas|Diane|Dianette|SH 714|SH-714|cyproterone acetate	A synthetic hormone being studied for treatment of hot flashes in men with prostate cancer who have had both testicles removed by surgery.
C1060	Daidzein	Isoflavone|Tyrosine_Kinase_Inhibitor	Daidzein|4',7-Dihydroxyisoflavone|7-Hydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one	An isoflavone extract from soy, which is an inactive analog of the tyrosine kinase inhibitor genistein. It has antioxidant and phytoestrogenic properties. (NCI)
C1061	Daunorubicin-DNA_Complex	DNA_Adduct	Daunorubicin-DNA Complex|DNR-DNA complex|Daunomycin-DNA Complex	A complex comprised of Daunorubicin linked to DNA to enhance the topoisomerase II-mediated interaction with the DNA base pairs and reduce cardiotoxicity associated with anthracyclines. (NCI)
C1062	Duborimycin	Anthracycline_Antibiotic	Duborimycin|13-Hydroxydaunomycin|5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(1-hydroxyethyl)-1-methoxy-, (8S-cis)-, hydrochloride|Daunomycinol|Daunomycinol HCl|Daunorubicineal|Duborimycin Hydrochloride|Duborimycine|Duborimycine, Hydrochloride	An anthracycline antineoplastic antibiotic with therapeutic effects similar to those of doxorubicin.  Duborimycin exhibits cytotoxic activity through topoisomerase-mediated interaction with DNA, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)
C1063	Defensins	Peptide	Defensins
C1064	Defibrotide	Anticoagulant_Agent	Defibrotide|defibrotide	A drug under study for the prevention of veno-occlusive disease, a rare complication of high-dose chemotherapy and stem cell transplantation in which small veins in the liver become blocked.
C1065	Desmethylmisonidazole	Radiosensitizing_Agent	Desmethylmisonidazole|Demethylmisonidazole|Ro 05-9963|SR-1530	A radiosensitizer that targets hypoxic cells and act as oxygen substitute making tumor cells sensitive to radiation damage.
C1066	Detorubicin	Anthracycline_Antibiotic	Detorubicin|14-Diethoxyacetoxydaunorubicin|Diethoxy-,2-(4-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-2-naphthacenyl)-2-oxoethyl ester,(2S-cis) Acetic Acid	A semi-synthetic derivative of the anthracycline antineoplastic antibiotic daunorubicin.  Detorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.  Detorubicin is less toxic than daunorubicin. (NCI04)
C1067	Dexamethasone_Acetate	Dexamethasone	Dexamethasone Acetate|Dalalone DP|Dalalone LA|Decadron LA|Dectancyl|Dexamethasone acetate|Dexasone LA|Solurex LA	The acetate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (NCI04)
C1068	Anguidine	Mycotoxin|Protein_Synthesis_Inhibitor	Anguidine|3.Alpha,4.Beta, 15-triol, 12, 13-epoxy-,4, 15-diacetate (8CI)|4, 15-Diacetoxyscirpen-3-ol|4.Beta, 15-diacetoxy-3.alpha-hydroxy-12, 13-epoxytrichothec-9-ene|ANGUIDINE|Anguidin|DAS|Diacetoxyscirpenol|MM 4462|Trichothec-9-ene-3, 4, 15-triol, 12, 13-epoxy-, 4, 15-diacetate (3.alpha, 4.beta)-(9CI)|Trichothec-9-ene-3, 4,15-triol, 12,13-epoxy-, 4,15-diacetate, (3.alpha.,4.beta.)- (9CI)|Trichothec-9-ene-3,4, 15-triol, 12,13-epoxy-, 4,15-diacetate|Trichothec-9-ene-3,4, 15-triol, 12,13-epoxy-, 4,15-diacetate, (3.alpha.,4.beta.)- (9CI)|Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 4, 15-diacetate|Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 4,15-diacetate|Trichothec-9-ene-3,4,15-triol, 12,13-epoxy-, 4,15-diacetate, (3.alpha.,4.beta.)- (9CI)	A trichothecene mycotoxin and potent teratogen. Anguidine inhibits initiation of protein synthesis, resulting in the death of rapidly proliferating cells.  Anguidine also has been shown to both potentiate and protect against the cytotoxic effects of other drugs.  (NCI04)
C1069	Dibenzo_a_l_Pyrene	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	Dibenzo (a,l) pyrene|1,2,3,4-Dibenzopyrene|DB(a,l)P|Dibenzo(def,p)chrysene|Dibenzo[a,l]pyrene	A yellowish-reddish, carcinogenic aromatic hydrocarbon consisting of six fused rings and produced by the incomplete combustion of organic matter. Dibenzo[a,e]pyrene is primarily found in coal gasification products, cigarette smoke and fossil fuels. This substance is used only for research purposes to induce tumorigenesis. Dibenzo[a,e]pyrene is a mutagen and is reasonably anticipated to be a human carcinogen.
C1070	Iproplatin	Platinum_Compound	Iproplatin|(OC-6-33)-dichlorodihydroxybis(2-propanamine)platinum|CHIP|JM-9|Platinum, dichlorodihydroxybis(2-propanamine)-, (oc-6-33)-	A synthetic second-generation platinum-containing compound related to cisplatin. Iproplatin binds to and forms DNA crosslinks and platinum-DNA adducts, resulting in DNA replication failure and cell death.  Although less prone to glutathione inactivation compared to cisplatin, resistance to this agent has been observed in vitro due to repair of platination damage by tumor cells. (NCI04)
C1071	Porfimer_Sodium	Hematoporphyrin_Derivative	Porfimer Sodium|CL-184116|DHE|Dihematoporphyrin Ester|Dihematoporphyrin Ether|Hematoporphyrin derivative|Photofrin|Photofrin II|Porfimer|dihematoporphyrin ether|photofrin|porfimer sodium	A drug used in photodynamic therapy that is absorbed by tumor cells.  When absorbed by cancer cells and exposed to light, photofrin becomes active and kills the cancer cells.
C1072	_1_1-Dimethylhydrazine	Organo-nitrogen_Carcinogen	1,1-Dimethylhydrazine|Dimazine|Dimethylhydrazine|UDMH	A clear, colorless, flammable, hygroscopic liquid with a fishy smell that emits toxic fumes of nitrogen oxides when heated to decomposition, and turns yellow upon contact with air. 1,1-Dimethylhydrazine is mainly used as a high-energy fuel in jets and rockets, but is also used in chemical synthesis, in photography and to control the growth of vegetation. This substance is also found in tobacco products. Exposure to 1,1-dimethylhydrazine results in irritation of skin, eyes and mucous membranes, and can affect liver and central nervous system. 1,1-Dimethylhydrazine is reasonably anticipated to be a human carcinogen. (NCI05)
C1073	Dimethylbusulfan	Alkylsulfonate_Compound	Dimethylbusulfan|DMM|Dimethyl Myleran|Dimethyl-Myleran|Dimethylmyleran	An aliphatic analogue of busulfan with potential antineoplastic activity.  As an alkylating agent, dimethylbusulfan induces neutropenia and has been shown to exhibit antitumor effects in some animal models.  Alkylating agents exert cytotoxic and chemotherapeutic effects by transferring alkyl groups to DNA, thereby damaging DNA and interfering with DNA synthesis and cell division. (NCI04)
C1074	Dinoprost_Tromethamine	Miscellaneous_Hormone_Agent|Teratogen	Dinoprost Tromethamine|Dinoprost tromethamine|Prostin F2 alpha	A synthetic analogue of the naturally occurring prostaglandin F2 alpha.  Prostaglandin F2 alpha stimulates myometrial activity, relaxes the cervix, inhibits corpus luteal steroidogenesis, and induces luteolysis by direct action on the corpus luteum. (NCI04)
C1075	Doxorubicin-DNA_Complex	DNA_Adduct	Doxorubicin-DNA Complex|Adriamycin-DNA Complex	A complex comprised of Doxorubicin linked to DNA to enhance the topoisomerase II-mediated interaction with the DNA base pairs and reduce cardiotoxicity associated with anthracyclines. (NCI)
C1076	Dromostanolone	Anabolic_Steroid|Therapeutic_Androgen	Dromostanolone|17 Beta-hydroxy-2 alpha-methyl-5 alpha-androstan-3-one|2 Alpha-5 alpha-17 beta-17-hydroxy-2-methyl-androstan-3-one|2 Alpha-methylandrostan-17 beta-ol-3-one|2 Alpha-methyldihydrotestosterone|2.alpha.-Methyldihydrotestosterone|5.alpha.-Androstan-3-one, 17.beta.-hydroxy-2.alpha.-methyl-|Drostanolone	A synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects. Dromostanolone inhibits the growth of estrogen receptor-presenting breast cancers; its virilizing effects limit its clinical usefulness. (NCI04)
C1077	Dromostanolone_Propionate	Dromostanolone	Dromostanolone Propionate|2 Alpha-Methyldihydrotestosterone Propionate|2-Alpha-Methyldihydrotestosterone Propionate|2.alpha.-Methyldihydrotestosterone propionate|Compound 32379|Drolban|Drostanolone Propionate|Drostanolone propionate|Emdisterone|Masterid|Masteril|Masteron|Masterone|Permastril	The propionate salt form of dromostanolone, a synthetic anabolic steroid related to dihydrotestosterone that has antiestrogenic effects.  Dromostanolone inhibits the growth of estrogen receptor-presenting breast cancers; its virilizing effects limit its clinical usefulness. (NCI)
C1078	Brequinar_Sodium	Brequinar	Brequinar Sodium|Brequinar sodium|DUP-785|DUP785|Sodium 6-Fluoro-2-(2'-fluoro-4-biphenylyl)-3-methyl-4-quinolinecarboxylate	The sodium salt form of Brequinar.  Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis.  This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. (NCI04)
C1079	Dynemicin_A	Enediyne_Antitumor_Antibiotic	Dynemicin A	An enediyne antineoplastic antibiotic hybrid containing an anthraquinone moiety isolated from the bacterium Micromonospora chersina.  The anthraquinone moiety intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in double-strand breaks in DNA, inhibition of DNA replication and apoptosis. (NCI04)
C1080	Elsamitrucin	Miscellaneous_Antineoplastic_Antibiotic|Topoisomerase-II_Inhibitor	Elsamitrucin|10-O-Elsaminosylelsarosylchartarin|BBM 2478A|BMY-28090|BRN 5214813|Benzo(h)(1)benzopyrano(5,4,3-cde)(1)ebnzopyran-5,12-dione,10((2-O-(2-amino-2,6-dideoxy-3-O-methyl-alpha-D-galactopyranosyl)-6-deoxy-3-C-methyl-beta-D-galactopyranosyl)oxy)-6-hydroxy-1-methyl|Elsamicin A|Elsamitrucina|Elsamitrucine|Elsamitrucinum	An heterocyclic antineoplastic antibiotic isolated from the bacterium Actinomycete strain J907-21.  Elsamitrucin intercalates into DNA at guanine-cytosine (G-C)-rich sequences and inhibits topoisomerase I and II, resulting in single-strand breaks and inhibition of DNA replication. (NCI04)
C1081	Eutectic_Mixture_of_Local_Anesthetics	Anesthetic_Agent	Eutectic Mixture of Local Anesthetics|EMLA|Lidocaine-Prilocaine Eutectic Mixture|Lidocaine/Prilocaine	A topical anesthetic cream, containing lidocaine 2.5% and prilocaine 2.5%, that provides neuralgia pain relief by causing loss of cutaneous sensation through reversible blockade of conduction in nerve fibers. (NCI)
C1082	Enocitabine	Pyrimidine_Antagonist	Enocitabine	A pyrimidine antimetabolite converted to Cytarabine in the body. (NCI)
C1083	Staphylococcal_Enterotoxin_A	Enterotoxin|Superantigen	Staphylococcal Enterotoxin A|SEA	Staphylococcal enterotoxin A.  A superantigen and member of a family of genetically related proteins produced by Staphylococcus aureus and Streptococcus pyogenes.  An extremely potent activator of T lymphocytes when presented on MHC class II antigens.
C1084	Staphylococcal_Enterotoxin_B	Enterotoxin|Superantigen	Staphylococcal Enterotoxin B|SEB	Staphylococcal enterotoxin B.  The prototype superantigen; a member of a family of genetically related proteins produced by Staphylococcus aureus and Streptococcus pyogenes.  An extremely potent activator of T lymphocytes when presented on MHC class II antigens.
C1085	Staphylococcal_Enterotoxin_C	Enterotoxin|Superantigen	Staphylococcal Enterotoxin C|SEC	Staphylococcal enterotoxin C.  A superantigen and member of a family of genetically related proteins produced by Staphylococcus aureus and Streptococcus pyogenes.  An extremely potent activator of T lymphocytes when presented on MHC class II antigens.
C1086	Toxic_Shock_Syndrome_Toxin-1	Superantigen	Toxic Shock Syndrome Toxin-1|TSST-1	Staphylococcal toxic shock syndrome toxin 1.  A superantigen with the potential to suppress plasma cell differentiation and antibody responsiveness. Potent pyrogen, induces T lymphocyte proliferation, requiring interleukin 1 release from macrophages, suppresses immunoglobulin production, enhances endotoxin shock, and enhances hypersensitivity skin reactions. Causes staphylococcal toxic shock syndrome (TSS).
C1087	EO9	Bioreductive_Agent|Miscellaneous_Alkylating_Agent	EO9|3-hydroxymethyl-5-aziridinyl-1-methyl-2-(1H-indole-4,7-dione) prop-beta-en-alpha-ol	A bioreductive prodrug when activated is an alkylating agent and may have cytotoxic effects in hypoxic tumor cells. (NCI)
C1088	Epigallocatechin_Gallate	Green_Tea_Extract	Epigallocatechin Gallate|(-)-Epigallocatechin 3-gallate|(2R-cis)-3,4-Dihydro-5,7-dihydroxy-2-(3,4,5-trihydroxyphenyl)-2H-1-benzopyran-3-yl 3,4,5-Trihydroxybenzoate|EGCG|Epigallocatechingallate|Tea catechin	A phenolic antioxidant found in a number of plants such as green and black tea. It inhibits cellular oxidation and prevents free radical damage to cells. It is under study as a potential cancer chemopreventive agent. (NCI)
C1089	Epitiostanol	Anabolic_Steroid|Therapeutic_Androgen	Epitiostanol	An androgenic anabolic steroid having potent anti-estrogenic effect, which inhibits the progression of estrogen-stimulated cancers such as breast cancer. (NCI)
C1090	Estradiol_Valerate	Therapeutic_Estradiol	Estradiol Valerate|ESTRADIOL VALERATE	The parenterally-administered synthetic valerate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.  As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors.  This agent exhibits mild anabolic and metabolic properties, and increases blood coagulability. (NCI04)
C1091	Estrone-Sulfate	Therapeutic_Estrone	Estrone-Sulfate	An aqueous substance that is the sulfate salt form of estrone. (NCI)
C1092	Etanidazole	Bioreductive_Agent|Radiosensitizing_Agent	Etanidazole|2-Nitro-imidazole Derivative|SR-2508|etanidazole	A 2-nitroimidazole with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the cytotoxicity of ionizing radiation. This agent may also be useful as an imaging agent for identifying hypoxic, drug-resistant regions of primary tumors or metastases.  (NCI04)
C1093	Etoposide_Phosphate	Etoposide	Etoposide Phosphate|ETOPOSIDE PHOSPHATE|Etopophos	A phosphate salt of a semisynthetic derivative of podophyllotoxin. Etoposide binds to the enzyme topoisomerase II, inducing double-strand DNA breaks, inhibiting DNA repair, and resulting in decreased DNA synthesis and tumor cell proliferation. Cells in the S and G2 phases of the cell cycle are most sensitive to this agent. (NCI04)
C1094	Fludarabine	Purine_Antagonist|Ribonucleotide_Reductase_Inhibitor	Fludarabine|2-Fluoro-9-beta-arabinofuranosyladenine|2-Fluorovidarabine|9-Beta-D-arabinofuranosyl-2-fluoro-9H-purin-6-amine|9-Beta-D-arabinofuranosyl-2-fluoroadenine|FLUDB|fludarabine	A fluorinated nucleotide antimetabolite analog of the antiviral agent vidarabine (ara-A) with antineoplastic activity. Administered parenterally as a phosphate salt, fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite may inhibit DNA polymerase alpha, ribonucleotide reductase and DNA primase, thereby interrupting DNA synthesis and inhibiting tumor cell growth.  (NCI04)
C1095	Pyrimethamine-Sulfadoxine	Antimalarial_Agent	Pyrimethamine-Sulfadoxine|Fansidar|Pyrimethamine Sulfadoxine	A combination product containing pyrimethamine and sulfadoxine.  Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR).  DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins.  Sulfadoxine competitively antagonizes paraaminobenzoic acid (PABA), resulting in disruption of folic acid synthesis and ultimately DNA synthesis. Sulfadoxine acts synergistically with pyrimethamine. (NCI04)
C1096	Fazarabine	Pyrimidine_Antagonist	Fazarabine|1,3, 5-Triazin-2(1H)-one, 4-Amino-1-beta-D- arabinofuranosyl- (9CI)|1,3, 5-Triazin-2(1H)-one, 4-amino-1-.beta.-D- arabinofuranosyl- (9CI)|1-.beta.-D-Arabinofuranosyl-5-azacytosine|1-Beta-D-arabinofuranosyl-5-azacytosine|Ara AC|Kymarabine|fazarabine	An anticancer drug that belongs to the family of drugs called antimetabolites.
C1097	Exemestane	Steroidal_Aromatase_Inhibitor	Exemestane|6-Methyleneandrosta-1,4-diene-3,17-dione|Aromasin|EXEMESTANE|FCE-24304|exemestane	A synthetic androgen analogue.  Exemestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens. (NCI04)
C1098	Fenretinide	Retinoic_Acid_Agent	Fenretinide|4-(all-trans-retino-yl)aminophenol|4-HPR|4-Hydroxyphenylretinamide|All-trans-4'-Hydroxyretinanilide|Fenretinimide|HPR-4|McN-R-1967|N-(4-hydroxyphenyl)retinamide|all-trans-4'-hydroxyretinanilide|all-trans-N-(4-Hydroxyphenyl)retinamide|all-trans-N-4'-hydroxyretinanilide|fenretinide	A drug being studied for cancer prevention.  It belongs to the family of drugs called retinoids.
C1099	Finasteride	Anti-Androgen|_5_Alpha-Reductase_Inhibitor	Finasteride|(5alpha,17beta)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide|Chibro-Proscar|FINASTERIDE|Finastid|MK 906|Pro-Cure|Propecia|Propeshia|Proscar|Prostide|Urprosan|finasteride	A drug used to reduce the amount of male hormone (testosterone) produced by the body.
C1100	Cefixime	Cephalosporin_Antibiotic	Cefixime|CEFIXIME|FK 027	A broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity. As does penicillin, the beta-lactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins.
C1101	Flavone_Acetic_Acid	Bioflavonoid|Endothelial_Cell_Inhibitor	Flavone Acetic Acid|4H-1-Benzopyran-8-acetic acid, 4-oxo-2-phenyl-|4H-1-benzopyran-8-acetic Acid, 4-Oxo-2-phenyl|FAA|Flavone acetic acid|Flavone-8-Acetic Acid|LM 975	A synthetic flavonoid with vascular targeting properties. Flavone acetic acid exhibits an antiproliferative effect on endothelial cells as a result of a superoxide-dependent mechanism, which induces changes in permeability of the vasculature of the tumor. This agent may stimulate tumor necrosis and promote shunting of blood flow to viable regions of the tumor, increasing their oxygenation and rendering them more susceptible to the antitumor effects of hyperthermia and ionizing radiation.  (NCI04)
C1102	Fludarabine_Phosphate	Fludarabine	Fludarabine Phosphate|2-F-ara-AMP|9H-Purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-|9H-purin-6-amine, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)|Beneflur|FLUDARABINE PHOSPHATE|Fludara|fludarabine-5'-monophosphate	The phosphate salt of fludarabine, a synthetic purine nucleoside antimetabolite with antineoplastic activity.  Preferentially transported into malignant cells and metabolized to its active form 2-fluoro-ara-ATP by deoxycytidine kinase, fludarabine inhibits alpha DNA polymerase and RNA reductase and competes with deoxyadenosine triphosphate, resulting in inhibition of DNA primase, inhibition of DNA synthesis, and cell death. (NCI04)
C1103	Fludrocortisone	Therapeutic_Glucocorticoid	Fludrocortisone Acetate|FLUDROCORTISONE ACETATE|Florinef|Florinef Acetate|Florinef acetate|Fludrocortisone|Fludrocortisone acetate|fludrocortisone	A synthetic corticosteroid. It is used to replace steroid hormones normally produced by the adrenal gland.
C1104	Fluosol-DA	Blood_Substitute	Fluosol-DA	A perfluorocarbon blood substitute in trials for the treatment of severe anemia
C1105	Diethylstilbestrol_Diphosphate	Non-Steroidal_Estrogen	Diethylstilbestrol Diphosphate|(E)-4,4'-(1,2-ethenediyl)-bisphenol bis(dihydrogen phosphate)|Alpha,alpha'-diethyl-4,4'-stilbenediol Diphosphoric Acid Ester|DESP|Diethyldihydroxystilbene Diphosphate|Diethylstilbestrol 4,4'-Diphosphoric Ester|Diethylstilbestryl Diphosphate|Fosfestrol|Fosfestrol Sodium Phosphoestrolum|Honvan|Honvol|ST-52|Stilbestrol Diphosphate|Stilboestrol Diphosphate|Stilphostrol	A synthetic nonsteroidal estrogen that competes with androgen receptors and prevents further growth of androgen dependent tumor cells. (NCI)
C1106	Fotemustine	Nitrosourea_Compound	Fotemustine|1-[N-(2-chloroethyl)-N-nitrosoureido]ethylphosphonic acid diethyl ester|Muphoran|S 10036|[1-[[[(2-chloroethyl)nitrosamino]-carbonyl]amino]ethyl]phosphonic acid diethyl ester|diethyl[1-[3-(2-chloroethyl)-3-nitrosoureido]ethyl]phosphonate	A chloroethylating nitrosourea with antineoplastic activity. Fotemustine alkylates guanine by forming chloroethyl adducts at the 6 position of guanine, resulting in N1-guanine and N3-cytosine cross linkages, inhibition of DNA synthesis, cell cycle arrest, and finally apoptosis. This agent is lipophilic and crosses the blood-brain barrier.
C1107	Fumonisin_B1	Mycotoxin	Fumonisin B1|FB1|Fumonisin B(1)|Macrofusine	A mycotoxin produced by Fusarium moniliforme.  It is a contaminant of cereals, especially corn.  It has been epidemiologically linked to high incidence of human esophageal cancer in South Africa and China and to hepatocarcinogenesis in animal models.
C1108	Gabapentin	Anticonvulsant_Agent	Gabapentin|1-(aminomethyl)cyclohexaneacetic Acid|GABAPENTIN|Neurontin|gabapentin	A substance that is being studied as a treatment for relieving hot flashes in women with breast cancer.  It belongs to the family of drugs called anticonvulsants.
C1109	Gallium_Nitrate	Malignancy-Associated_Hypercalcemia_Inhibitor	Gallium Nitrate|Gallium nitrate|Ganite|WR-135675|gallium nitrate	A drug that lowers blood calcium. Used as treatment for hypercalcemia (too much calcium in the blood) and for cancer that has spread to the bone (bone metastases).
C1110	Ganglioside_GD2	Ganglioside|Tumor_Antigen	Ganglioside GD2|GD2 ganglioside	A carbohydrate specific cell surface antigen expressed by human neuroblastomas, sarcomas, astrocytomas, epithelial cancers, and melanomas. Belongs to the group of glycosphingolipids and gangliosides that are widely expressed in many tissues and organs in vertebrates and have been suggested to be involved in the regulation of development and differentiation as recognition molecules or signal modulators. The data on Ganglioside GD2 expression and distribution in both biopsied and cultured melanomas provides the rationale for its potential use as a component of a polyvalent anti-melanoma vaccines.(NCI)
C1111	Gastrin_Releasing_Peptide_Therapeutic	Retired_Concepts	Gastrin Releasing Peptide (Therapeutic)|GRP (Therapeutic)
C1112	Geldanamycin	Ansamycin_Antineoplastic_Antibiotic	Geldanamycin|GELDANAMYCIN	A benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus.  Geldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90).  HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be over-expressed or overactive in tumor cells. (NCI04)
C1113	Genistein	Isoflavone|Topoisomerase-II_Inhibitor|Tyrosine_Kinase_Inhibitor	Genistein|4',5, 7-Trihydroxyisoflavone|4',5,7-Trihydroxyisoflavone|5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one|Genestein|Genisteol|Prunetol|genistein	A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation.  This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest.  Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. (NCI04)
C1114	Glaucarubolone	Quassinoid_Agent	Glaucarubolone	A polycyclic lactone quassinoid phytochemical isolated from the seeds of Hannoa undulata and other plant species with potential antineoplastic activity.  This agent also has antiviral and antitumor properties. (NCI04)
C1115	Glutamic_Acid	Non-Essential_Amino_Acid	Glutamic Acid|L-Glutamic Acid
C1116	Glycosylphosphatidylinositol	Phosphatidylinositol	Glycosylphosphatidylinositol
C1117	Glycyrrhizin	Triterpenoid_Compound	Glycyrrhizin|(3beta,20beta)-20-Carboxy-11-oxo-30-norolean-12-en-3-yl-2-O-beta-D-glucopyranuronosyl-alpha-D-glucopyranosiduronic Acid|Dipotassium Glycyrrhizate|Glycyrrhizic Acid
C1118	Gossypol_Acetic_Acid	Gossypol	Gossypol Acetic Acid|Gossypol Acetate	The naturally occurring acetic acid form of gossypol, and an orally available polyphenolic aldehyde derived mostly from cottonseed with potential antineoplastic activity.  The biologic activities of gossypol acetic acid are similar to those of gossypol and include suppression of DNA replication, inhibition of tumor cell proliferation, and male contraceptive effects. (NCI04)
C1119	Ondansetron	Antiemetic_Agent	Ondansetron|ONDANSETRON|Zofran ODT|ondansetron	A carbazole derivative with antiemetic activity.  As a selective serotonin receptor antagonist, ondansetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. (NCI04)
C1120	Halofuginone	Miscellaneous_Angiogenesis_Inhibitor	Halofuginone|trans-(+/-)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4(3H)-quinazolinone	An orally-active quinazolinone alkaloid with potential antineoplastic activity.  Halofuginone interferes with the signaling pathway of transforming growth factor beta (TGF beta) and inhibits matrix metalloproteinase 2 (MMP 2), thereby inhibiting collagen type I synthesis and inducing extracellular matrix degradation, resulting in inhibition of angiogenesis, tumor growth and invasion, and metastasis. (NCI04)
C1121	HC-Toxin	Histone_Deacetylase_Inhibitor	HC-Toxin|Cyclic(L-alanyl-D-alanyl-eta-oxo-L-alpha-aminooxiraneoctanoyl-D-prolyl)|Cyclo(D-Pro-L-Ala-D-Ala-L-Aeo)	A host-specific toxin from the maize pathogen Cochliobolus carbonum.  An inhibitor of histone deacetylase, it is a cyclic tetrapeptide containing an epoxide alpha-amino acid.  Inhibition of histone deacetylase is sensitive to mercaptoethanol treatment.
C1122	Therapeutic_Hepatocyte_Growth_Factor	Therapeutic_Growth_Factor	Recombinant Hepatocyte Growth Factor|HGF|HGF/SF|Hepatopoietin|Scatter Factor	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein cytokine hepatocyte growth factor (HGF), which is produced by the liver and the pancreas.  Endogenous HGF synthesis is stimulated by injuries affecting liver tissues.  This agent, a potent angiogenic and neurotrophic factor and a multifunctional cytokine that acts as a mitogen, motogen and a morphogen, is important for organogenesis and tissue regeneration.  Therapeutic HGF has been shown to attenuate brain ischemic injury in animal models through angiogenic and neuroprotective actions. (NCI04)
C1123	Hepsulfam	Alkylsulfonate_Compound	Hepsulfam|1,7-Heptanediyl Ester Sulfamic Acid|HEPSULFAM|Sulfamic acid, 1,7-heptanediyl ester	A bisulfamic ester which is similar in structure to busulfan and belongs to the family of drugs known as alkylsulfonate alkylating agents.  Hepsulfam forms covalent linkages with nucleophilic centers in DNA, resulting in depurination, base miscoding, strand scission, DNA-DNA and DNA-protein cross-linking, and cytotoxicity. (NCI04)
C1124	Herbimycin	Ansamycin_Antineoplastic_Antibiotic	Herbimycin|17-Demethoxy-15-methoxy-11-O-methylgeldanamycin, (15R)-|Herbimycin A	A benzoquinone antineoplastic antibiotic isolated from the bacterium Streptomyces hygroscopicus.  Herbimycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90).  HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be over-expressed or overactive in tumor cells. (NCI04)
C1125	Hexamethylene_Bisacetamide	Differentiation_Inducer|Ethylenimine_Compound	Hexamethylene Bisacetamide|Acetamide, N,N'-1, 6-hexanediylbis-|Acetamide, N,N'-hexamethylenebis-|HMBA|Hexamethylene Bisacetamide (HMBA)|Hexamethylene bisacetamide|Hexamethylenebisacetamide|Hexamethylenediacetamide|N, N'-Diacetylhexamethylenediamine|N,N'-1,6-Hexanediylbisacetamide|N,N'-Hexamethylenebisacetamide	A hybrid polar-planar compound with potential antineoplastic activity that induces terminal differentiation, inhibits cell growth, and causes apoptosis in several tumor cell lines.  Its precise mechanism of action is unknown. (NCI04)
C1126	Haemophilus_Influenzae_B_Vaccine	Conjugate_Vaccine	Haemophilus Influenzae B Vaccine|ActHIB|Haemophilus b conjugate vaccine|Haemophilus b oligosaccharide conjugate vacccine|Haemophilus influenzae B Polysaccharide Conjugate Vaccine (PRP-OMP)|Haemophilus influenzae B Polysaccharide Conjugate Vaccine (PRP-T)|Hib TITER vaccine|HibTITER|PedvaxHIB	A vaccine against serotype b of the Gram-negative bacterium H. influenzae (Hib).  Hib vaccines contain polysaccharide-protein conjugate antigens that produce greater host immune responses than first-generation purified polysaccharide vaccine.  These vaccines may differ with regard to use of protein carriers, polysaccharides, diluents, and preservatives. (NCI04)
C1127	Homoharringtonine	Antineoplastic_Plant_Product|Differentiation_Inducer	Homoharringtonine|Ceflatonin|Cephalotaxine, 4-Methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester)|Cephalotaxine, 4-Methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester), [3(R)]- (9CI)|Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]- (9CI)|HHT|homoharringtonine	A cytotoxic plant alkaloid isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity.  Homoharringtonine binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation.  This agent also induces differentiation and apoptosis in some cancer cell types. (NCI04)
C1128	Leflunomide	Angiogenesis_Activator_Inhibitor|Dihydroorotate_Dehydrogenase_Inhibitor|Pyrimidine_Antagonist	Leflunomide|4-Isoxazolecarboxamide, 5-Methyl-N-(4-(trifluoromethyl)phenyl)-|Arava|LEFLUNOMIDE|SU101|leflunomide	A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties.  As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes.  This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. (NCI04)
C1129	Hydrazine_Sulfate	Hydrazine	Hydrazine Sulfate|Sehydrin|hydrazine sulfate	A substance that has been studied as a treatment for cancer and as a treatment for cachexia (body wasting) associated with advanced cancer.
C1130	Hydroxyl_Radical	Free_Radicals	Hydroxyl Radical	A monovalent radical consisting of one hydrogen and oxygen atom found in bases, carboxylic acids, and alcohols.(NCI)
C1131	Tropisetron	Antiemetic_Agent	Tropisetron|ICS 205-930|Navoban	An indole derivative with antiemetic activity.  As a selective serotonin receptor antagonist, tropisetron competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy-and radiotherapy-induced nausea and vomiting. (NCI04)
C1132	IMREG-1	Immunostimulant	IMREG-1|IMREG 1	IMREG-1 is a leukocyte-derived immunomodulator isolated from serum of HIV- negative individuals. An experimental anti-AIDS drug.
C1133	ImuVert	Immunostimulant|Miscellaneous_Chemoprotective_Agent	ImuVert|Serratia Marcescens Extract	A biological response modifier produced from the bacterium Serratia marcescens that activates mononuclear cells, causing release of various cytokines. (NCI)
C1134	Indicine-N-Oxide	Antimitotic_Agent|Antineoplastic_Plant_Product	Indicine-N-Oxide|2,3-Dihydroxy-2-(1-methylethyl)butanoic Acid (2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl)methyl Ester N-Oxide|Butanoic Acid, 2,3-Dihydroxy-2-(1-methylethyl)- (2,3,5, 7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl) Methyl Ester, N-Oxide,(1R-(1.alpha.,7(2R*,3S*),7a.beta))-(9CI)|Butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)- (2,3,5, 7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl) methyl ester, N-oxide, (1R-(1.alpha.,7(2R*,3S*),7a.beta))-(9CI)|Indicine N-Oxide|Indicine N-oxide|Indicine, N-oxide|NSC 132319	A natural pyrrolizidine alkaloid with antineoplastic properties.  Indicine-N-oxide alkylates and crosslinks DNA. (NCI04)
C1135	Indole-3-Carbinol	Antiestrogen|Antioxidant	Indole-3-Carbinol|1H-indole-3-methanol|I3C|Indole-3-carbinol|indole-3-carbinol	A naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, a natural compound present in a wide variety of plant food substances including members of the family Cruciferae with antioxidant and potential chemopreventive properties. Indole-3-carbinol scavenges free radicals and induces various hepatic cytochrome P450 monooxygenases. Specifically, this agent induces the hepatic monooxygenase cytochrome P4501A1 (CYP1A1), resulting in increased 2-hydroxylation of estrogens and increased production of the chemoprotective estrogen 2-hydroxyestrone.
C1136	Inosine_Dialdehyde	Purine_Antagonist	Inosine Dialdehyde|9H-Purine-9-acetaldehyde, .alpha.-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R,R)- (8CI)|9H-Purine-9-acetaldehyde, .alpha.-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R-(R*, R*))- (9CI)|9H-purine-9-acetaldehyde, alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R,R)- (8CI)|9H-purine-9-acetaldehyde, alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R-(R*, R*))- (9CI)|Diglycolaldehyde|Diglycolaldehyde, .alpha.-(hydroxymethyl)-.alpha.'-(6-hydroxy-9H-purin-9-yl)-|IdA|Inosine dialdehyde|Inox|NSC 118994|Wy-5321|diglycolaldehyde, alpha-(hydroxymethyl)-.alpha.'-(6-hydroxy-9H-purin-9-yl)	A toxic purine analogue. Inosine dialdehyde inhibits ribonucleotide reductase, resulting in decreased synthesis of DNA, RNA, and proteins, and G2/M-phase cell cycle arrest.  This agent also forms stable covalent crosslinks in proteins, thereby inhibiting the activity of enzymes involved in nucleic acid synthesis. (NCI04)
C1137	Iopromide	Contrast_Agent	Iopromide	A contrast medium.
C1138	Itraconazole	Antifungal_Agent	Itraconazole|Sporanox|itraconazole	A drug used to prevent or treat fungal infections.  It belongs to the family of drugs called antifungal agents.
C1139	Keyhole_Limpet_Hemocyanin	Immunostimulant	Keyhole Limpet Hemocyanin|KLH|keyhole limpet hemocyanin	A natural protein isolated from the marine mollusc keyhole limpet.  Keyhole limpet hemocyanin is an immunogenic carrier protein that, in vivo, increases antigenic immune responses to haptens and other weak antigens such as idiotype proteins. (NCI04)
C1140	KW-2149	Mitomycin_Antibiotic	KW-2149|7-N-(2-((2-(gamma-L-Glutamylamino)ethyl)dithio)ethyl)mitomycin C|KT6149|KW 2149	A semisynthetic water-soluble disulfide derivative of the antineoplastic antibiotic mitomycin C.  Activated by serum and glutathione, KW-2149 causes interstrand DNA cross-links and DNA-protein cross-links, resulting in single-strand DNA breaks and inhibition of DNA synthesis. (NCI04)
C1141	Carboxyamidotriazole	Miscellaneous_Angiogenesis_Inhibitor	Carboxyamidotriazole|1H-1,2,3-Triazole-4-carboxamide, 5-amino-1-((3,5-dichloro-4(4-chlorobenzoyl)phenyl)methyl)|5-Amino-1-((3,5-dichloro-4-(4-chlorobenzoyl)phenyl)methyl)-1H-1,2,3-triazole-4-carboxamide|CAI|Carboxyamido-triazole|Carboxyaminoimidazole|L651582|carboxyamidotriazole	An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors.
C1142	Lavendustin_A	Tyrosine_Kinase_Inhibitor	Lavendustin A|5-(((2,5-Dihydroxyphenyl)methyl)((2-hydroxyphenyl)methyl)amino)-2-hydroxy Benzoic Acid|Benzoic acid, 5-[[(2, 5-dihydroxyphenyl)methyl][(2-hydroxyphenyl)methyl]amino]-2-hydroxy -	A compound isolated from strains of Streptomyces griseolavendus that may exert antitumor activity by inhibition of protein tyrosine kinase and tubulin polymerization. (NCI)
C1143	Therapeutic_Leukoregulin	Therapeutic_Cytokine	Recombinant Leukoregulin	A formulated therapeutic analog of the endogenous lymphokine leukoregulin with potential antineoplastic activity.  Leukoregulin displays direct and indirect cytotoxicity through tumor cell lysis and enhancing tumor cell susceptibility to natural killer cell-mediated cytotoxicity.  This agent enhances membrane permeability and decreases p-glycoprotein expression, thereby promoting cytotoxic drug uptake into tumor cells.  Leukoregulin also induces the synthesis of collagenase and hyaluronan, expression and secretion of interleukin-8, and upregulates stromelysin-1 gene expression in human fibroblasts, thereby regulating extracellular matrix degradation. (NCI04)
C1144	Nafarelin	Gonadotropin-Releasing_Hormone_Analog	Nafarelin|6-D-(2-naphthyl)alanyl-GnRH|Nafarelin Acetate|RS-94991298|Synarel|Synarela|Synrelina
C1145	Lignans	Aromatic_Hydrocarbon|Phytoestrogen	Lignans|Lignan
C1146	Lonidamine	Multidrug_Resistance_Modulator|Radiosensitizing_Agent	Lonidamine|AF 1890|Diclondazolic Acid|Doridamina	An indazole carboxylic acid derivative that exhibits radiosensitizing and antiparasitic effects and interferes with the multidrug resistance mechanism.
C1147	Therapeutic_Interleukin-16	Therapeutic_Gamma_Chemokine|Therapeutic_Interleukin	Recombinant Interleukin-16|IL-16|Interleukin-16|Lymphocyte Chemoattractant Factor|Lymphotactin	A recombinant chemokine of human lymphotactin which is produced by activated progenitor T cells and characterized by specific chemotactic activity for lymphocytes. (NCI)
C1148	Therapeutic_Lymphotactin	Therapeutic_Gamma_Chemokine	Recombinant Lymphotactin|Lymphotactin	A recombinant chemokine of human lymphotactin which is produced by activated progenitor T cells and characterized by specific chemotactic activity for lymphocytes. (NCI)
C1149	Maalox	Antacid_Preparation	Maalox	An antacid consisting of either a single agent (Calcium Carbonate) or combination of agents (Aluminum Hydroxide and Magnesium Hydroxide). Some formulations contain an anti-gas agent (Simethicone). (NCI)
C1150	Mafosfamide	Nitrogen_Mustard_Compound	Mafosfamide|mafosfamide	A form of cyclophosphamide that can be administered as an intrathecal infusion.  Mafosfamide is being studied as an anticancer drug.  It belongs to the family of drugs called alkylating agents.
C1151	Mannose-Binding_Lectin	Miscellaneous_Biologic_Response_Modifier	Mannose-Binding Lectin|MBL|Mannose Binding Lectin	A normal plasma protein belonging to the collectin family. It contains a carbohydrate recognition domain at one end and a collagen-like stalk domain at the other. The presence of many carbohydrate binding sites within a single molecule of mannose-binding lectin results in very high binding to microorganisms. Upon this binding the complement system is activated through the action of associated serine proteases. Activation of the complement system leads to the deposition of complement components on the surface of the microorganisms (opsonisation) and to clearance of the microorganisms by phagocytic cells. Preclinical and clinical studies suggest that administration of the agent to deficient individuals will restore lectin function in vivo and thereby be beneficial in management of the immunodeficiency. (NCI)
C1152	Marcellomycin	Anthracycline_Antibiotic	Marcellomycin|1-Naphthacenecarboxylic acid, 4-[[O-2,6-dideoxy-.alpha.-L-lyxo-hexopyranosyl-(1.fwdarw.4)-O-2, 6-dideoxy-.alpha.-L-lyxo-hexopyranosyl-(1.fwdarw.4)-2,3, 6-trideoxy-3-(dimethylamino)-.alpha.-L-lyxo-hexopyranosyl]oxy]-2-e thyl-1,2,3,4,6,11-hexahydro-2,5,7,10-tetrahydroxy-6,11-dioxo-, methyl ester, (1R-(1.alpha.,2.beta.,4.beta.))- (9CI)|MARCELLOMYCIN|Rhodirubin E	An antineoplastic oligosaccharide anthracycline antineoplastic antibiotic isolated from the bacterium Actinosporangium bohemicum.  Marcellomycin intercalates into DNA and induces DNA crosslinks, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also induces differentiation in HL-60 promyelocytic leukemia cells by interfering with glycoprotein synthesis. (NCI04)
C1153	Dolasetron_Mesylate	Antiemetic_Agent	Dolasetron Mesylate|Anzemet|Dolasetron|MDL 73,147EF	An indole derivative with antiemetic activity.  As a selective serotonin receptor antagonist, dolasetron mesylate competitively blocks the action of serotonin at 5HT3 receptors, resulting in suppression of chemotherapy- and radiotherapy-induced nausea and vomiting. (NCI04)
C1154	Carbendazim	Tubulin_Binding_Agent	Carbendazim|1H-Benzimidazol-2-yl-carbamic Acid, Methyl Ester|1H-benzimidazol-2-ylcarbamic Acid Methyl Ester|2-(Methoxycarbonylamino)benzimidazole|2-Benzimidazolecarcamic Acid Methyl Ester|2-Methyl benzimidazolecarbamate|BAS 3460|BAS-3460|BAS-67054|BCM|BMC|Bavistin|CTR 6669|CTR-6669|Carbendazole|Derosal|FB642|HOE 17411|HOE-17411|MBC|Methyl 2-Benzimidazolecarbamate|Methyl 2-benzimidazolecarbamate|Methyl Benzimidazol-2-ylcarbamate|Methyl-1H-benzimidazol-2-yl Carbamate|Methyl-2-benzimidazole Carbamate|Methyl-2-benzimidazolecarbamate|Methyl-alpha-benzimidazole Carbamate|carbendazim	An anticancer drug that belongs to the family of drugs called antifungal agents.
C1155	Medroxyprogesterone_17-Acetate	Therapeutic_Progestin	Medroxyprogesterone 17-Acetate|(6alpha)-17-(Acetyloxy)-6-methylpregn-4-ene-3,20-dione|17-(Acetyloxy)-6alpha-methylpregn-4-ene-3,20-dione|17-Hydroxy-6alpha-methylpregn-4-ene-3,20-dione Acetate|17Alpha-acetoxy-6alpha-methylprogesterone|6-Alpha-methyl-17alpha-acetoxyprogesterone|Amen|Aragest|Ciclotal|Clinofem|Clinovir|Cycrin|Depo-Clinovir|Depo-Provera|Depo-provera|Depot-Medroxyprogestereone Acetate|Farlutal|G-Farlutal|Gestapuran|Hysron|Lutoral|MEDROXYPROGESTERONE ACETATE|MPA|Medroxyprogesterone Acetate|Medroxyprogesterone acetate|Medroxyprogesteroni Acetas|Methylacetoxyprogesterone|Metipregnone|Nadigest|Nadigest (vet)|Nidaxin|Nidaxin (vet)|Oragest|Perlutex|Prodasone|Provera|Sodelut G|Veramix	A synthetic, acetate derivative of the sex hormone progesterone.  Medroxyprogesterone 17-acetate (NCI04)
C1156	Megestrol_Acetate	Megestrol	Megestrol Acetate|(9beta,10alpha)-17-(Acetyloxy)-6-methylpregna-4,6-diene-3,20-dione|17 Alpha-acetoxy-6-methylpregna-4,6-diene-3,20-dione|17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione Acetate|17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate|17.alpha.-Acetoxy-6-methylpregna-4,6-diene-3,20-dione|6-Dehydro-6-methyl-17 alpha-acetoxyprogesterone|6-Dehydro-6-methyl-17.alpha.-acetoxyprogesterone|6-Methyl-6-dehydro-17.alpha.-acetoxyprogesterone|6-Methyl-delta-4,6-pregnadien-17 alpha-ol-3,20-dione Acetate|BDH 1298|BDH-1298|MEGESTROL ACETATE|Maygace|Megace|Megestat|Megestil|Niagestin|Ovaban|Pallace|SC-10363	The acetate salt form of megestrol, a synthetic derivative of progesterone with antiestrogenic activity.  Megestrol binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. In addition, megestrol stimulates the appetite in cachectic subjects. (NCI)
C1157	GRO1_Protein_Recombinant	Therapeutic_Alpha_Chemokine	Recombinant GRO1 Protein|GRO Protein, Alpha|GRO1 Protein|MGSA|Melanoma Growth Stimulatory Activity|Neutrophil Activating Protein 3
C1158	Mepitiostane	Antiestrogen	Mepitiostane	An anabolic ether-modified form of the steroid epitiostanol. It has anti-estrogenic effect, which inhibits the progression of estrogen-stimulated cancers by competitive inhibition of estrogen binding to estrogen receptors. (NCI)
C1159	Methanol_Extraction_Residue_of_BCG	BCG	Methanol Extraction Residue of BCG|BCG-MER|MER BCG|MER of BCG|MER-BCG|Methanol Extraction Residue of Bacillus Calmette-Guerin	A cell wall fraction of bacillus Calmette-Guerin (BCG) obtained by menthol extraction with immunomodulating properties and potential use in cancer immunotherapy. (NCI04)
C1160	Meropenem	Beta-Lactam_Antibiotic	Meropenem|MEROPENEM|Merrem I.V.|SM-7338	A broad-spectrum carbapenem with antibacterial properties, synthetic Meropenem inhibits cell wall synthesis in gram-positive and gram-negative bacteria. It penetrates cell walls and binds to penicillin-binding protein targets. Meropenem acts against aerobes and anaerobes including Klebsiella, E. coli, Enterococcus, Clostridium sp.. (NCI04)
C1161	Metoprine	Dihydrofolate_Reductase_Inhibitor|Folate_Antagonist	Metoprine|BW 197U|DDMP	A diaminopyrimidine folate antagonist with potential antineoplastic activity.  Metoprine inhibits dihydrofolate reductase, resulting in decreased cellular folate metabolism and cell growth; it also inhibits histamine-N-methyltransferase, resulting in decreased histamine catabolism. Lipid-soluble metoprine is capable of crossing the blood-brain barrier. (NCI04)
C1162	Methylene_Dimethane_Sulfonate	Miscellaneous_Alkylating_Agent	Methylene Dimethane Sulfonate	A member of the homologous series of dimethane sulphonic acid esters with alkylating properties. Methylene dimethane sulfonate alkylates DNA, resulting in interstrand DNA crosslinking, inhibition of DNA replication, disruption of the cell cycle, and cell death.
C1163	N-Methylformamide	Differentiation_Inducer|Radiosensitizing_Agent	N-Methylformamide|EK 7011|Formamide, N-methyl|Monomethylformamide|N-Methyl-Formamide|NSC 3051|X 188|formylmethylamine|monomethylformamide	A water-soluble organic solvent.  As an adjuvant antineoplastic agent, N-methylformamide depletes cellular glutathione, a key molecule involved in the antioxidation of reactive oxygen species (ROS) and other free radicals, thereby enhancing ionizing radiation-induced DNA cross-linking in and terminal differentiation of tumor cells. (NCI04)
C1164	Mitomycin_A	Mitomycin_Antibiotic	Mitomycin A|Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-6,8a-dimethoxy-5-methyl-, carbamate (ester)	A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus.  Bioreduced mitomycin A generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis.  Mitomycin A is more toxic than mitomycin C due to increased and nonselective DNA cross-linking in both aerobic and hypoxic cells. (NCI04)
C1165	_2-Ethylhydrazide	Epipodophyllotoxin_Compound	2-Ethylhydrazide	A podophyllic acid derivative of podophyllotoxin, a substance extracted from the mandrake root Podophyllum peltatum.  Possessing potent antineoplastic properties, 2-ethylhydrazide binds to and inhibits topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. (NCI)
C1166	Mitozolomide	Triazene_Compound	Mitozolomide|Azolastone|Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-chloroethyl)-3,4-dihydro-4-oxo-|imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3-(2-chloroethyl)-3,4-dihydro-4-oxo	An imidazotetrazine alkylating agent that inhibits DNA replication by creating DNA cross-linkages. (NCI)
C1167	Cystemustine	Nitrosourea_Compound	Cystemustine|C6H12CLN3O4S|CMSO2EN2|N'-(2-chloroethyl)-N-(2-(methylsulfonyl)ethyl)-N'-nitrosourea|N-(2-chloroethyl)-N'-[2-methylsulfonyl)ethyl]-N-nitroso-urea	A chloroethylating nitrosourea that causes DNA cross-linking, inhibiting DNA replication. (NCI)
C1168	N_1_N_11_bis_ethyl_norspermine	Polyamine_Inhibitory_Agent	N(1),N(11)-bis(ethyl)norspermine|CI-1006|DENSPM|N(1),N(11)-diethylnorspermine|N1,N11-bis(ethyl)norspermine	A polyamine analog being tested for the treatment of solid tumors
C1169	Carboxyphenyl_Retinamide	Retinoic_Acid_Agent	Carboxyphenyl Retinamide|4-carboxyphenyl retinamide|N-(4-Carboxyphenyl)retinamide|N-(4-carboxyphenyl)retinamide	A synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities.  Carboxyphenyl retinamide induces cell differentiation and inhibits tumor cell growth and carcinogenesis.  This agent may also induce cell cycle arrest in the G1 phase in some cancer cell types. (NCI04)
C1170	Miltefosine	Alkylphosphocholine_Compound	Miltefosine|2-[[(Hexadecycloxy)hydroxyphosphinyl]oxy]-N,N,N-trimethylethanaminium Inner Salt|Choline Phosphate Hexadecyl Ester, Hydroxide, Inner Salt|D-18506|Hexadecyl 2-(N,N,N-trimethylamino)ethyl Phosphate|Hexadecylphosphocholine|Miltefosin|Miltefosina|Miltefosinum|Miltex|n-Hexadecylphosphorylcholine	An orally- and topically-active alkyl-phosphocholine compound with potential antineoplastic activity.  Miltefosine targets cellular membranes, modulating cell membrane permeability, membrane lipid composition, phospholipid metabolism, and mitogenic signal transduction, resulting in cell differentiation and inhibition of cell growth.  This agent also inhibits the anti-apoptotic mitogen-activated protein kinase (MAPK) pathway and modulates the balance between the MAPK and pro-apoptotic stress-activated protein kinase (SAPK/JNK) pathways, thereby inducing apoptosis.  As an immunomodulator, miltefosine stimulates T-cells, macrophages and the expression of interleukin 3 (IL-3), granulocyte-macrophage colony stimulating factor (GM-CSF), and interferon gamma (INF-gamma). (NCI04)
C1171	Nabilone	Antiemetic_Agent	Nabilone|Cesamet|Cpd 109514
C1172	Nandrolone_Decanoate	Nandrolone	Nandrolone Decanoate|Deca-Durabolin|NANDROLONE DECANOATE	The decanoate salt form of nandrolone, an oil based injectable anabolic steroid analog of testosterone.  Nandrolone binds to and activates specific nuclear receptors.  This agent has moderate androgenic effects, promotes protein anabolism and stimulation of erythropoietin production. (NCI)
C1173	Nilutamide	Anti-Androgen	Nilutamide|1-(3'-Trifluoromethyl-4'-nitrophenyl)-4,4-dimethylimidazoline-3,5-dione|5,5-Dimethyl-3-[4-nitro-3-(trifluoro-methyl)phenyl]-2,4-imidazolidinedione|Anandron|NILUTAMIDE|Nilandron|RU-23908|nilutamide	A drug that blocks the effects of male hormones in the body.  It belongs to the family of drugs called antiandrogens.
C1174	Novembichin	Nitrogen_Mustard_Compound	Novembichin	A nitrogen mustard agent that crosslinks with DNA, causing inhibition of DNA synthesis. (NCI)
C1175	Olive_Oil	Food_Oil	Olive Oil|Oil, Olive	Produced by pressing olives, Olive Oil has a high content of monounsaturated fats, thought beneficial for health. Major components of the phenolic fraction of olive oil, lignans and pinoresinols are potent antioxidants present in extra virgin (first pressed) oils. Containing vitamins E and F, other antioxidant compounds, foods containing high amounts of lignan precursors may be protective against breast, colon, and prostate cancer, as well as heart diseases. Used mainly in cooking today, olive oil has been used for medicines and in cosmetics. (NCI04)
C1176	Olsalazine	Nonsteroidal_Antiinflammatory_Drug	Olsalazine|3,3'-Azobis[6-hydroxybenzoic Acid]|3,3'-Dicarboxy-4,4'-dihydroxyazobenzene|Azodisalicylate|C.I. Mordant Yellow 5|Dipentum	A derivative of aminosalicylic acid exhibiting anti-inflammatory effects when converted to mesalamine in the colon. (NCI)
C1177	Oltipraz	Chemopreventive_Agent	Oltipraz|3H-1,2-Dithiole-3-thione, 4-methyl-5-pyrazinyl-|3H-1,2-Dithiole-3-thione,4-methyl-5-pyrazinyl|4-Methyl-5-(pyrazinyl)-3H-1,2-dithiole-3-thione|4-Methyl-5-pyrazinyl-3H-1,2-dithiole-3-thione|5-(2-Pyrazinyl)-4-methyl-1,2-dithiol-3-thione|5-[2-Pyrazinyl]-4-methyl-1,2-3-thione|RP-35,972|oltipraz	A dithiolethione which can prevent DNA damage induced by the mammary carcinogen dibenzo[a,l]pyrene (DBP).
C1178	NG-Monomethyl-L-Arginine	Miscellaneous_Chemoprotective_Agent	NG-Monomethyl-L-Arginine|N-Methylarginine|N-Methylarginine (NMA)|NG-monomethyl-L-arginine|NMA	An amino acid derivative used to counteract high blood pressure caused by interleukin-2.
C1179	Papillomavirus_Type_16_Protein-E7	Papillomavirus_Transforming_Protein-E7	Human Papillomavirus Type 16, E7 Protein|HPV-16 E7|HPV-16 E7 peptide|HPV16 E7
C1180	Therapeutic_Oncostatin_M	Therapeutic_Cytokine	Recombinant Oncostatin M|OSM
C1181	Oxaliplatin	Platinum_Compound	Oxaliplatin|1-OHP|DACPLAT|Dacotin|Dacplat|Diaminocyclohexane Oxalatoplatinum|ELOXATIN|Eloxatin|Eloxatine|JM-83|Oxalatoplatin|Oxalatoplatinum|RP 54780|RP-54780|SR-96669|[(1R,-2R)-1,2-cyclohexanediamine-N,N'][oxalato (2--)-O,O']platinum|[SP-4-2-(1R-trans)]-(1,2,cyclohexanediamine-N,N')[ethanedioato(2--)-O,O']platinum|oxalato (1R,2R-cyclohexanediamine)platinum(II)|oxalato (trans-l-1,2-diaminocyclohexane)platinum(II)|oxaliplatin|trans-l DACH oxalatoplatinum|trans-l diaminocyclohexane oxalatoplatinum	An anticancer drug that belongs to the family of drugs called platinum compounds.
C1182	Piroxantrone	Anthrapyrazole_Antibiotic	Piroxantrone|Anthra(1,9-cd)pyrazol-6(2H)-one, 5-((3-aminopropyl)amino)-7,10-dihydroxy-2-(2-((2-hydroxyethyl)amino)ethyl)|CI-942|Oxanthrazole|PD-111815|Piroxantrone HCl	An anthrapyrazole antineoplastic antibiotic.  Piroxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  Although less cardiotoxic than doxorubicin, this agent exhibits a narrow spectrum of antineoplastic activity. (NCI04)
C1183	Ranpirnase	Protein_Synthesis_Inhibitor	Ranpirnase|Onconase|P-30|P-30 Protein|P-30 protein|P30|P30 Protein	A natural homologue of ribonuclease A isolated from the eggs of the frog Rana pipiens.  Ranpirnase primarily degrades cellular transfer RNA with a substrate specificity for uridine-guanidine base-pair sequences, resulting in inhibition of protein synthesis and cytotoxicity. This agent also activates caspase-9 in mitochondria, resulting in tumor cell apoptosis. (NCI04)
C1184	Pancratistatin	Antineoplastic_Plant_Product|Tubulin_Binding_Agent	Pancratistatin	A isoquinoline alkaloid from amaryllis with antineoplastic activity.
C1185	Therapeutic_Parathyroid_Hormone-Related_Protein	Therapeutic_Growth_Factor	Recombinant Parathyroid Hormone-Related Protein|PTH-like protein|PTHrP|Parathyroid Hormone Like Tumor Factor|Parathyroid Hormone-Related Peptide|Parathyroid Hormone-Related Protein	calcium-regulating hormone with endocrine, paracrine, and autocrine actions in bone; can cause hypercalcemia.
C1186	PCNU	Nitrosourea_Compound	PCNU|1-(2-Chloroethyl)-3-(2,6-Dioxo-3-Piperidyl)-1-Nitrourea|NSC-95466	A chloroethylnitrosourea compound that inhibits DNA synthesis by cross linking and may be associated with pulmonary, hepatic, and hematologic toxicity. (NCI)
C1187	Penberol	Unclassified_Chemotherapy_Agent	Penberol|cis-beta-4-pentoxy-benzoyl-beta-bromoacrylic acid|cis-beta-4-pentoxybenzoyl-beta-bromoacrylic acid	A cytostatic compound that has been used as an antineoplastic agent against ovarian carcinoma. (NCI)
C1188	Penclomedine	Picoline_Compound	Penclomedine|3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl) pyridine|CRC 88-04|Pyridine, 3,5-dichloro-2,4-dimethoxy-6-(trichloromethyl)-|penclomedine	A synthetic derivative of pyrimidine with antineoplastic activity. Penclomedine alkylates and crosslinks DNA, resulting in DNA strand breaks and inhibition of DNA and RNA synthesis. This agent is more active against tumor cells that are defective in p53 function. (NCI04)
C1189	Pentamethylmelamine	Ethylenimine_Compound	Pentamethylmelamine|1,3,5-Triazine-2,4,6-triamine, N,N,N',N', N''-pentamethyl-, monohydrochloride (9CI)|Melamine|Melamine, N2,N2,N4,N4,N6-pentamethyl-, monohydrochloride|N,N,N',N',N"-pentamethyl-1,3,5-triazine|PMM|Pentamethylmelamine MonoHCl|Pentamethylmelamine Monohydrochloride|Pentamethylmelamine monoHCl|Pentamethylmelamine monohydrochloride|melamine, N2,N2,N4,N4,N6-pentamethyl-, monohydrochloride	A principal metabolite of hexamethylmelamine with antineoplastic activity.  Pentamethylmelamine alkylates DNA and other macromolecules and forms DNA intrastrand and DNA-protein crosslinks, thereby preventing DNA replication. (NCI04)
C1190	Phenesterin	Nitrogen_Mustard_Compound	Phenesterin|(3-beta)-cholest-5-en-3-ol 4-(bis(2-chloroethyl)amino)benzeneacetate|(4-(bis(2-chloroethyl)amino)phenyl)acetic acid cholesteryl ester|(p-(bis(2-chloroethyl)amino)phenyl) acetate cholesterol|(p-(bis(2-chloroethyl)amino)phenyl)acetic acid cholesteryl ester|5-cholesten-3-beta-ol 3-(p-bis(2-chloroethyl)amino)phenyl) acetate|Cholest-5-en-3-ol, (3.beta.)-, 4-[bis(2-chloroethyl)amino]benzeneacetate|Cholest-5-en-3beta-ol 4-(bis(2-chloroethyl)amino)benzeneacetate|Cholesteryl p-bis(2-chloroethyl)aminophenylacetate|Fenesterin|Fenestrin|NCI-C01558|NSC 104469|Phenesterine|p-bis(2-chloroethyl)amino phenylacetate cholesterol	A steroidal nitrogen mustard with antineoplastic and mutagenic activities. After attachment to cell-surface steroid receptors and uptake, phenesterin enters the nucleus where it alkylates macromolecules, resulting in decreased cell proliferation. (NCI04)
C1191	Phenol	Phenol_Compound	Phenol	Hydroxybenzene; Carbolic Acid. Used as a germicidal agent and as an intermediate in chemical synthesis.  Highly toxic; corrosive to the skin.
C1192	Phosphatidylinositol_4_5-bisphosphate	Intracellular_Second_Messenger|Phosphatidylinositol	Phosphatidylinositol 4,5-bisphosphate	Phosphatidylinositol 4,5-Diphosphate; PIP2.  A phosphoinositide present in all eukaryotic cells, particularly in the plasma membrane. It is the major substrate for receptor-stimulated phosphoinositidase C, with the consequent formation of inositol 1,4,5-triphosphate (IP3) and diacylglycerol, and probably also for receptor-stimulated inositol phospholipid 3-kinase. (Kendrew, The Encyclopedia of Molecular Biology, 1994)
C1193	Foscarnet	Anti-HIV_Agent|Reverse_Transcriptase_Inhibitor	Foscarnet Sodium|FOSCARNET SODIUM|Foscarnet|Foscavir|Phosphonoformate Trisodium	A synthetic organic analogue of inorganic pyrophosphate with antiviral properties.  Foscarnet (trisodium phosphonoformate) selectively blocks the pyrophosphate binding site of virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases.  Because this agent crosses the blood brain barrier, it may be used in the treatment of viral infections of the CNS.  (NCI04)
C1194	Phytoestrogen	Environmental_Estrogen	Phytoestrogen	Compounds from plant sources with estrogen-like activities
C1195	Piceatannol	Tyrosine_Kinase_Inhibitor	Piceatannol|3,4,3',5'-Tetrahydroxy-trans-stilbene	A polyhydroxylated stilbene extract from the seeds of Euphorbia lagascae, which inhibits protein tyrosine kinase Syk and induces apoptosis. (NCI)
C1196	Pimonidazole	Bioreductive_Agent|Radiosensitizing_Agent	Pimonidazole|Ro 03-8799	A nitroimidazole hypoxic cell sensitizer that selectively binds to thiol-containing proteins in hypoxic cells. Pimonidazole may be used as a hypoxia marker for detecting oxygen gradients in living tissues. In addition, it also exhibits radiosensitizing properties. (NCI)
C1197	Pirarubicin	Anthracycline_Antibiotic	Pirarubicin|(2"R)-4'-O-Tetrahydropyranyladriamycin|(8S,10S)-10-[[3-Amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-3-yl)-alpha-L-lyxo-hexopyranosyl]oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione|1609RB|4'-O-Tetrahydropyranyl Doxorubicin|Pinorubicin|THP-ADM|THP-Adriamycin|THP-Doxorubicin|Tepirubicin|Tetrahydropyranyl-Doxorubicin|Theprubicine|Therarubicin|[8S-[8Alpha,10alpha(S*)]]-10-[[3-amino-2,3,6-trideoxy-4-O-(tetrahydro-2H-pyran-2-yl)-alpha-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-5,12-naphthacenedione	An analogue of the anthracycline antineoplastic antibiotic doxorubicin.  Pirarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines. (NCI04)
C1198	Poly_ICLC	Immunostimulant	Poly ICLC|Poly I:Poly C with Poly-1-Lysine Stabilizer|Poly I:PolyC with Poly-1-Lysine Stabilizer|Polyinosinic-Polycytidylic Acid Stabilized with Polylysine and Carboxymethylcellulose|Polyriboinosinic-Polyribocytidylic Acid-Polylysine Carboxymethylcellulose|Stabilized Polyriboinosinic/Polyribocytidylic Acid	A synthetic complex of carboxymethylcellulose, polyinosinic-polycytidylic acid, and poly-L-lysine double-stranded RNA. Poly ICLC may stimulate the release of cytotoxic cytokines and, by inducing interferon-gamma production, may increase the tumoricidal activities of various immunohematopoietic cells. (NCI04)
C1199	Polyestradiol_Phosphate	Therapeutic_Estradiol	Polyestradiol Phosphate|Estradiol Phosphate Polymer|Estradurin|PEP	A synthetic long-acting polymer derivative of the female sex hormone estradiol.  As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors.  Estradiol exhibits mild anabolic and metabolic properties, and increases blood coagulability.  Administration of polyestradiol phosphate leads to the marked decrease of testosterone levels and may exhibit a bone mass-preserving effect in patients with prostatic cancer. (NCI04)
C1200	Pegaspargase	Protein_Synthesis_Inhibitor	Pegaspargase|(Monomethoxypolyethylene Glycol Succinimidyl)74-L-Asparaginase|L-Asparaginase with Polyethylene Glycol|Oncaspar|PEG-Asparaginase|PEG-L-Asparaginase|PEG-L-Asparaginase(K-H)|PEGLA|Polyethylene Glycol L-Asparaginase|Polyethylene Glycol-L-Asparaginase|pegaspargase	A complex of polyethylene glycol conjugated with L-asparaginase.  Asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thereby depleting these cells of asparagine and blocking protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle.  The agent also induces apoptosis in tumor cells. Pegylation decreases the enzyme's antigenicity. Asparagine is critical to protein synthesis in leukemic cells, which cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase. (NCI04)
C1201	Polysialic_Acid	Antigen	Polysialic Acid	Polysialic acid (PSA) is a carbohydrate composed of a linear homopolymer of alpha-2-8-linked sialic acid residues. It plays important role in formation and remodeling of the neural system through modulation the adhesive properties of the neural cell adhesion molecule (NCAM) and augmentation of the cellular motility. Although PSA is lost from most adult tissues, reexpression of PSA-NCAM has been demonstrated in some malignant tumors: Wilms tumor, neuroblastoma, natural killer cell derived-lymphoma, pancreatic carcinoma, small cell lung cancer. PSA overexpression appears related to the metastatic potential of these tumors.(NCI)
C1202	Prednisolone_Acetate	Prednisolone	Prednisolone Acetate|Ak-Tate|Articulose-50|Balpred|Deltacortilen|Deltastab|Di-Adreson-F|Diopred|Econopred|Hexacortone|Hydrocortancyl|Inf-Oph|Inflanefran|Key-Pred|Locaseptil-Neo|Ophtho-Tate|PREDNISOLONE ACETATE|Pred Fort|Pred Forte|Pred Mild|Predaject|Predalone|Predate|Predcor|Prednefrin SF|Predni-H|Predni-POS|Prednihexal|Predniocil|Prednisolone acetate	The acetate salt form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.  After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production.  This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI)
C1203	Therapeutic_Prothymosin_Alpha	Miscellaneous_Hormone_Agent	Recombinant Prothymosin Alpha|Prothymosin Alpha	A recombinant form of the endogenous polypeptide hormone that exerts immunomodulatory effects primarily on mononuclear cells.  Prothymosin alpha stimulates the production of various cytokines including granulocyte/macrophage colony stimulating factor (GM-CSF) alpha, gamma interferon (IFN) and interleukins such as IL-2.  This agent may also increase some tumor antigens expression, thus inducing better T lymphocyte responses to tumor cells.  Combined with chemotherapy, prothymosin alpha may exhibit significant anti-tumor effects.  This agent also helps to regenerate lymph node and bone marrow cells after treatment with certain toxic chemotherapeutics. (NCI04)
C1204	Polysaccharide-K	Chemo_Immunostimulant_Adjuvant|Immunostimulant	Polysaccharide-K|Glycoproteins|Krestin|PSK	Protein-bound polysaccharide from the mushroom Coriolus versicolor (Shitake); a biological response modifier with antitumor activity.
C1205	Tectorigenin	Tyrosine_Kinase_Inhibitor	Tectorigenin|4',5,7-Trihydroxy-6-methoxyisoflavone|4H-1-benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)-8-methoxy-|Psi-Tectorigenin|psi-Tectorigenin	An isoflavone from Pueraria thunbergiana, which induces differentiation and apoptosis in cancer cells. (NCI)
C1206	Pteropterin	Folate_Antagonist	Pteropterin
C1207	Pyrazine_Diazohydroxide	DNA_Adduct_Forming_Agent	Pyrazine Diazohydroxide|Pyrazinamine, N-nitroso-, sodium salt|Pyrazine diazohydroxide|Pyrazineamine, N-nitroso-, sodium salt|pyrazinamine, N-nitroso-, sodium salt|pyrazine diazohydroxide|pyrazine-2-diazohydroxide|pyrazineamine, N-nitroso-, sodium salt	A congener of pyridine 2-diazohydroxide.  Pyrazine diazohydroxide forms DNA adducts via the reactive pyrazine diazonium ion, thereby inhibiting DNA synthesis. (NCI04)
C1208	Pyrazofurin	Orotidylate_Decarboxylase_Inhibitor|Pyrimidine_Antagonist	Pyrazofurin|.beta.-Pyrazomycin|1H-Pyrazole-5-carboxamide, 4-Hydroxy-3-beta-D-ribofuranosyl- (9CI)|1H-Pyrazole-5-carboxamide, 4-hydroxy-3-.beta.-D-ribofuranosyl- (9CI)|4-Hydroxy-3-.beta.-D-ribofuranosylpyrazole-5-carboxamide|4-Hydroxy-3-beta-D-ribofuranosylpyrazole-5-carboxamide|47599|Beta-Pyrazomycin|Compound 47599|PYRAZOFURIN|Pirazofurin|Pyrazole, -3-Carboxamide, 4-Hydroxy-5-beta-L-ribofuranosyl|Pyrazole, -3-carboxamide, 4-hydroxy-5-.beta.-L-ribofuranosyl-|Pyrazomycin	A nucleoside analog.  Pyrazofurin potently inhibits orotidine 5'-monophosphate (OMP) decarboxylase, thereby interfering with de novo synthesis of uridine nucleotides and resulting in cytotoxicity.  This agent also causes a rapid depletion of the pyrimidine deoxynucleotide pool, thereby inhibiting DNA synthesis and cell replication. (NCI04)
C1209	Pyrene	Aromatic_Compounds	Pyrene|PYRENE	A parent class of polycyclic aromatic hydrocarbons containing four fused rings. (IUPAC 1998)
C1210	Cisapride	Antiemetic_Agent	Cisapride|Propulsid|cis-4-Amino-5-Chloro-N-(1-(3- (p-fluorophenoxy)propyl)-3-methoxy-4- piperidyl)-o-Anisamide	A substituted piperidinyl benzamide prokinetic agent.  Cisapride facilitates release of acetylcholine from the myenteric plexus, resulting in increased gastrointestinal motility.  In addition, cisapride has been found to act as a serotonin agonist, stimulating type 4 receptors, and a serotonin 5-HT3 receptor antagonist. (NCI)
C1211	Therapeutic_RANTES	Therapeutic_Beta_Chemokine	Recombinant RANTES|CCL5|RANTES|Regulated on Activation, Normal T Expressed and Secreted|SIS delta|T-Cell RANTES Protein	A member of the IL-8 superfamily of cytokines and released from platelets and activated T-cells, RANTES is a selective chemoattractant for eosinophils, monocytes, and T-lymphocytes.  RANTES is one of the ligands for chemokine receptor CCR5. RANTES expression in peripheral lymphocytes increases exponentially following mitogenic or antigenic stimulation.  RANTES is one of the major HIV-suppressive factors produced by CD8-positive T-cells.  (NCI)
C1212	Sirolimus	Immunosuppressant|Macrolide_Antibiotic	Sirolimus|9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-((1R)-2-((1S,3R,4R)-4-hydroxy-3-methoxycyclohexyl)-1-methylethyl)-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclohentriacontine-1,5,11,2|AY 22989|RAPA|RAPAMYCIN|Rapamune|Rapamycin|SILA 9268A|WY-090217|sirolimus	A drug used to help prevent rejection of organ and bone marrow transplants by the body.
C1213	Rebeccamycin	Intercalating_Agent|Miscellaneous_Antineoplastic_Antibiotic|Topoisomerase-I_Inhibitor	Rebeccamycin|5H-Indolo[2, 3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione, 1,11-dichloro-12, 13-dihydro-12-(4-O-methyl-.beta.-D-glucopyranosyl)-|5H-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione,1,11-dichloro-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)|BRN 4732638|rebeccamycin	An anticancer drug that belongs to the family of drugs called antineoplastic antibiotics.
C1214	Resiniferatoxin	Nonnarcotic_Analgesic	Resiniferatoxin|RTX	A capsaicin
C1215	Resveratrol	Antioxidant	Resveratrol|(E)-5-[2-(4-Hydroxyphenyl)ethenyl]-1,3-benzenediol|3,4',5-Stilbenetriol|RESVERATROL	A phytoalexin derived from grapes and other food products with antioxidant and potential chemopreventive activities. Resveratrol induces phase II drug-metabolizing enzymes (anti-initiation activity); mediates anti-inflammatory effects and inhibits cyclooxygenase and hydroperoxidase functions (anti-promotion activity); and induces promyelocytic leukemia cell differentiation (anti-progression activity), thereby exhibiting activities in three major steps of carcinogenesis. This agent may inhibit TNF-induced activation of NF-kappaB in a dose- and time-dependent manner. (NCI05)
C1216	Retinyl_Acetate	Retinoic_Acid_Agent	Retinyl Acetate|Retinol Acetate|Retinyl acetate|Vitamin A, acetate|vitamin A acetate	A naturally-occurring fatty acid ester form of retinol (vitamin A) with potential antineoplastic and chemopreventive activities.  Retinyl acetate binds to and activates retinoid receptors, inducing cell differentiation and decreasing cell proliferation.  This agent also inhibits carcinogen-induced neoplastic transformation in some cancer cell types and exhibits immunomodulatory properties. (NCI04)
C1217	Retinyl_Palmitate	Retinoic_Acid_Agent	Retinyl Palmitate|Palmitate-1-14C|Retinol Hexadecanoate|Retinol Palmitate|Retinol-15-3H|Retinyl-10,11-14C2|Vitamin A Palmitate|retinyl palmitate	A drug being studied in cancer prevention.  It belongs to the family of drugs called retinoids.
C1218	Rhizoxin	Tubulin_Binding_Agent	Rhizoxin|WF-1360|rhizoxin	A macrocyclic lactone. Rhizoxin binds to tubulin and inhibits microtubule assembly, thereby inducing cytotoxicity. This agent also may inhibit endothelial cell-induced angiogenic activity, which may result in decreased tumor cell proliferation. (NCI04)
C1219	Ketorolac	Cyclooxygenase_Inhibitor	Ketorolac|Toradol|ketorolac	A drug that belongs to a family of drugs called nonsteroidal anti-inflammatory agents. It is being studied in cancer prevention.
C1220	Sm_153_Lexidronam_Pentasodium	Adjuvant_Analgesic|Radioconjugate	Samarium Sm 153 Lexidronam Pentasodium|153Sm-EDTMP|Quadramet|Samarium Sm 153 Lexidronam|Samarium Sm-153 EDTMP|Samarium-153 EDTMP|Samarium-153 Ethylenediaminetetramethylenephosphonate|Samarium-153 Ethylenediaminetetramethylenephosphonic Acid|Sm 153 Lexidronam Pentasodium|Sm-153 EDTMP	A medium energy beta-emitting radioisotope in a chelate form (ethylenediaminetetramethylenephosphonic acid).  It concentrates in bone tissue; used to provide relief to patients with painful bone metastases
C1221	Saperconazole	Antifungal_Agent	Saperconazole	A triazole antifungal agent.
C1222	SC-48334	Glucosidase_Inhibitor	Miglustat|1,5-(butylimino)-1,5-dideoxy-D-glucitol|3,4,5-Piperidinetriol, 1-butyl-2-(hydroxymethyl)-,(2R-(2alpha,3beta,4alpha,5beta))-|MIGLUSTAT|N-Butyl Deoxynojirimycin|N-Butylmoranoline|SC 48334|SC-48334|Zavesca	An anti-HIV agent that exerts its effect by inhibiting glucosylceramide synthase.
C1223	Selenocysteine	Cysteine	Selenocysteine|Sec	An unusual amino acid of proteins, the selenium analogue of cysteine, in which a selenium atom replaces sulphur. Involved in the catalytic mechanism of seleno enzymes such as formate dehydrogenase of E. Coli and mammalian glutathione peroxidase. (from On-line Medical Dictionary)
C1224	Atamestane	Steroidal_Aromatase_Inhibitor	Atamestane|atamestane	A drug being studied in the treatment of cancer.  It belongs to the family of drugs called antiestrogens.  Atamestane blocks the production of the hormone estrogen in the body.
C1225	Shiga_Toxin	Bacterial_Toxin	Shiga Toxin	A bacterial toxin produced by Shigella dysenteriae and by some strains of E. coli that inhibits protein synthesis by blocking the interaction of ribosomal RNA with peptide elongation factors.  The non-catalytic beta subunit of Shiga toxin may be useful as a fusion vector for induction of antigen-specific cytotoxic T lymphocyte responses.
C1226	Sialyl_Tn_Antigen	Tumor_Antigen	Sialyl Tn Antigen|STn|STn Antigen|Sialyl-Tn Antigen	Sialyl Tn antigen (SRn) is a carcinoma-associated core-region carbohydrate antigen of epithelial mucin, expressed in most colon carcinoma, mucinous carcinoma, pancreatic cancer, gastric, lung, breast, and ovarian carcinoma. Has been shown to be highly sensitive and specific marker of colorectal cancer, associated with more aggressive diseases and poor prognosis. Sialosyl-Tn antigen and its immediate precursor, Tn antigen, are mucin type glycoprotein structures associated with the earliest steps of mucin O- linked glycosylation. The vaccine is designed to stimulate a T cell response to STn. The synthetic antigen is combined with a carrier molecule, keyhole limpet hemocyanin (KLH), and is administered with oral cyclophosphamide as an immune modulator.
C1227	Simalikalactone_D	Quassinoid_Agent	Simalikalactone D|(+)-Simalikalactone D|Picras-3-ene-2,16-dione, 13,20-epoxy-1,11,12-trihydroxy-15-(2-methyl-1-oxobutoxy)-, (11beta)-	A quassinoid phytochemical isolated from Simaba multiflora, Quassia africana and other plant species with potential antineoplastic activity.  This agent also has antimalarial and antiviral properties. (NCI04)
C1228	Sodium_Molybdate	Nutritional_Supplement	Sodium Molybdate	A crystalline powder essential for the metabolism and development of plants and animals as a cofactor for enzymes. (NCI)
C1229	Sodium_Selenate	Antioxidant	Sodium Selenate|Selenate, Sodium	The sodium salt of selenium.  As a trace mineral that is toxic in high doses, selenium is a cofactor for glutathione peroxidase, an anti-oxidant enzyme that neutralizes hydrogen peroxide.  Selenium may be chemoprotective for certain cancers, particularly prostate cancer.  High dietary supplementation with sodium selenate may inhibit the progression of hormone-refractory prostate cancer due, in part, to an antiangiogenesis effect. (NCI04)
C1230	Sodium_Thiosulfate	Miscellaneous_Chemoprotective_Agent	Sodium Thiosulfate|Cyanide Antidote Package|Disodium Thiosulfate|Disodium thiosulfate|S-Hydril|Sodium Hyposulfate|Sodium Thiosulfate Pentahydrate|Sodium Thiosulphate|Sodium thiosulfate|Sodothiol|Thiosulfate, Sodium, Pentahydrate|Thiosulfuric Acid Disodium Salt|Thiosulfuric acid disodium salt	A water soluble salt and reducing agent that reacts with oxidizing agents.  Although its exact mechanism of action is unknown, thiosulfate likely provides an exogenous source of sulfur, thereby hastening the detoxification of cyanide through the enzyme rhodanese (thiosulfate cyanide sulfurtransferase) which converts cyanide to the relatively nontoxic, excretable thiocyanate ion. In addition, this agent neutralizes the reactive alkylating species of nitrogen mustard, thereby decreasing skin toxicity related to nitrogen mustard extravasation. (NCI04)
C1231	Spherex	Drug_Vehicle	Spherex|Starch Microspheres	A biodegradable starch microsphere used in arterial embolization.
C1232	Spirogermanium	Immunostimulant	Spirogermanium|2-Aza-8-germaspiro[4.5]decane-2-propanamine, 8, 8-diethyl-N,N-dimethyl-, Dihydrochloride|2-Aza-8-germaspiro[4.5]decane-2-propanamine, 8, 8-diethyl-N,N-dimethyl-, dihydrochloride|2-[3-(Dimethyl-amino)propyl]-8,8-diethyl-2-aza-8-germaspiro[4,5]decane|8,8-Diethyl-N,N-dimethyl-3-aza-8-germaspiro[4,5]decane-2-propanamine|S 99 A|Spiro 32|Spiro-32|Spirogermanium Compound|Spirogermanium HCl|Spirogermanium Hydrochloride|Spirogermanium compound|Spirogermanium hydrochloride	A synthetic organometallic compound containing the element germanium with possible antineoplastic activity. Spirogermanium exhibits significant toxicity, particularly neurotoxicity. (NCI04)
C1233	Spiromustine	Nitrogen_Mustard_Compound	Spiromustine|1,3-diazaspiro(4,5)decane-2,4-dione,3-(2-(bis-chloroethyl)amino)ethyl|SHM|Spirohydantoin Mustard|Spirohydantoin mustard	A bifunctional nitrogen alkylating agent with antineoplastic activity and lipophilic properties. Containing a lipophilic hydantoin group that serves as a carrier to cross the blood brain barrier, spiromustine forms covalent linkages with nucleophilic centers in DNA, causing depurination, base-pair miscoding, strand scission, and DNA-DNA cross-linking, which may result in cytotoxicity. (NCI04)
C1234	Spiroplatin	Platinum_Compound	Spiroplatin|Cis-1,1-diamino-methylcyclohexane sulfato-platinum|TNO-6	A synthetic derivative of cyclohexane sulfatoplatinum with antineoplastic properties.  Spiroplatin induces DNA cross-links, thereby inhibiting DNA replication and RNA and protein synthesis. Similar to other platinum compounds, this agent has been shown to be mutagenic and carcinogenic. (NCI04)
C1235	ST_638	Tyrosine_Kinase_Inhibitor	ST 638|2-Cyano-3-(3-ethoxy-4-hydroxy-5-((phenylthio)methyl)phenyl)-2-propenamide	A tyrosine kinase inhibitor that inhibits phospholipase D activity in human neutrophils at a site between the receptor and phospholipase. (NCI)
C1236	Staphage_Lysate	Immunostimulant	Staphage Lysate	Lysate of broth culture of two strains of coagulase positive Staphylococcus aureus with polyvalent Gratia bacteriophage; used in treatment of Hidradenitis Suppurativa
C1237	Staurosporine	Differentiation_Inducer|Protein_Kinase_A_Inhibitor|Protein_Kinase_C_Inhibitor	Staurosporine|(9alpha,10beta,11beta,13alpha)-(+)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H-9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one|8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)-|AM-2282|staurosporine	A cell permeable alkaloid isolated from Streptomyces staurosporeus exhibiting anti-cancer activity.  Staurosporine is a potent, non-selective inhibitor of protein kinases, including protein kinase C.  This agent induces apoptosis by an undetermined mechanism. (NCI)
C1238	Strontium_Chloride_Sr_89	Radioconjugate	Strontium Chloride Sr 89|Metastron|STRONTIUM CHLORIDE, SR-89	The chloride salt of a radioactive isotope of strontium. Strontium chloride Sr 89 is taken up and incorporated preferentially in metastatic lesions in bone where it emits cytotoxic beta radiation, resulting in an inhibition and/or reduction of tumor growth and so tumor-related bone pain. (NCI04)
C1239	Sulindac_Sulfone	Sulindac	Sulindac Sulfone|(Z)-5-Fluoro-2-methyl-1-[[4-(methylsulfonyl)phenyl]methylene]-1H-indene-3-acetic Acid|1H-Indene-3-acetic Acid, 5-Fluoro-2-methyl-1-((4-(methylsulfonyl)phenyl)methylene), (Z)|Aptosyn|Exisulind|FGN-1|Sulindac sulfone|exisulind	A drug that is being studied in the treatment and prevention of cancer.  It has been shown to cause apoptosis (cell death) in cancerous and precancerous cells by acting through a group of cellular enzymes called cGMP phosphodiesterases.
C1240	Sumatriptan	Antiemetic_Agent	Sumatriptan|SUMATRIPTAN	A sulfonamide serotonin agonist and vasoconstrictor that acts selectively at 5HT1 receptors and is used for the treatment of migraine in adults.
C1241	Sunflower_Oil	Food_Oil	Sunflower Oil|Oil, Sunflower|Sunflower Seed Oil	Pressed from sunflower seeds (Helianthus annus), Sunflower Oil has a high content of beneficial monounsaturated fats, and antioxidant vitamins E and F, as well as triglycerides and linoleic acids. Used mainly in cooking today, sunflower oil has been used for medicines and in cosmetics. (NCI04)
C1242	Tazobactam	Penicillin_Antibiotic	Tazobactam Sodium|TAZOBACTAM SODIUM|Tazobactam	A beta-lactamase inhibitor.
C1243	Tc_99m_Dextran	Radioconjugate	Tc 99m Dextran|Technetium 99m Dextran|Technetium Tc 99m Dextran|technetium Tc 99m dextran	A radiolabeled substance that is used in cancer diagnosis.
C1244	Temozolomide	Gonadotropin_Releasing_Hormone_Inhibitor|Triazene_Compound	Temozolomide|3,4-dihydro-3-methyl-4-oxoimidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide|8-carbamoyl-3-methylimidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one|CCRG-81045|Imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-|M & B 39831|M and B 39831|Methazolastone|RP-46161|SCH 52365|TEMOZOLOMIDE|Temodal|Temodar|imidazo[5,1-d]-1,2,3,5-tetrazine-8-carboxamide, 3, 4-dihydro-3-methyl-4-oxo-|temozolomide	A triazene analog of dacarbazine with antineoplastic activity.  As a cytotoxic alkylating agent, temozolomide is converted at physiologic pH to the short-lived active compound, monomethyl triazeno imidazole carboxamide (MTIC). The cytotoxicity of MTIC is due primarily to methylation of DNA at the O6 and N7 positions of guanine, resulting in inhibition of  DNA replication.  Unlike dacarbazine, which is metabolized to MITC only in the liver, temozolomide is metabolized to MITC at all sites. Temozolomide is administered orally and penetrates well into the central nervous system. (NCI04)
C1245	Terephthalamidine	Ring_Compound	Terephthalamidine|1,4-Benzenedicarboximidamide
C1246	Testosterone_Cypionate	Therapeutic_Testosterone	Testosterone Cypionate|17Beta-Cyclopentanepropionate|Depo-Testosterone|Depo-testosterone|Depotest|Depovirin|Pertestis|TESTOSTERONE CYPIONATE|Testosterone cypionate|Virilon|depAndro	An eight-carbon ester form of Testosterone. The number of ester carbon atoms correlate with the half-life of the prodrug.  Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels.  In addition, this agent promotes the maintenance of male sex characteristics and is indicated for testosterone replacement in hypogonadal males. (NCI04)
C1247	Testosterone_Enanthate	Therapeutic_Testosterone	Testosterone Enanthate|Andro LA|Androtardyl|Delatestryl|Everone|Primosteston|TESTOSTERONE ENANTHATE|Testate|Testinon|Testo-Enant|Testosterone enanthate	A long-acting intramuscular form of the androgen testosterone. Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels. In addition, this agent promotes the maintenance of male sex characteristics and is indicated for testosterone replacement in hypogonadal males, delayed puberty, and metastatic mammary cancer. (NCI04)
C1248	Testosterone_Isobutyrate	Therapeutic_Testosterone	Testosterone Isobutyrate|Perandren M	An four-carbon ester form of Testosterone. The number of ester carbon atoms correlate with the half-life of the prodrug.  Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels.  In addition, this agent promotes the maintenance of male sex characteristics and is indicated for testosterone replacement in hypogonadal males. (NCI04)
C1249	Testosterone_Undecanoate	Therapeutic_Testosterone	Testosterone Undecanoate|Andriol|Pantestone|Restandol|Testosterone 17Beta-Undecylate	An orally active eleven-carbon ester form of Testosterone. The number of ester carbon atoms correlate with the half-life of the prodrug.  Testosterone inhibits gonadotropin secretion from the pituitary gland and ablates estrogen production in the ovaries, thereby decreasing endogenous estrogen levels.  In addition, this agent promotes the maintenance of male sex characteristics and is indicated for testosterone replacement in hypogonadal males. (NCI04)
C1250	Ormaplatin	Platinum_Compound	Ormaplatin|Platinum, tetrachloro(1,2-cyclohexanediamine-N,N')-, (OC-6-22-(trans))-|Tetraplatin|tetrachloro(1,2-cyclohexanediamine-N,N')-, (OC-6-22-(trans))Platinum	A platinum(IV) analogue with antineoplastic activity. Also known as tetraplatin, ormaplatin alkylates DNA, forming both inter- and intra-strand platinum-DNA crosslinks, which result in inhibition of DNA replication and transcription and cell-cycle nonspecific cytotoxicity. (NCI04)
C1251	Thiamiprine	Purine_Antagonist	Thiamiprine	A cytotoxic purine antagonist that has both immunosuppressive and antiarthritic activity. (NCI)
C1252	Thiocolchicine	Tubulin_Binding_Agent	Thiocolchicine	An antimitotic alkaloid that binds to microtubules and inhibits tubulin polymerization and induces apoptosis. (NCI)
C1253	Thymalfasin	Chemo_Immunostimulant_Adjuvant|Immunostimulant	Thymalfasin|Thymosin Alpha 1|Zadaxin	A synthetic analogue of thymosin-alpha-1, a 28-amino acid protein derived from the precursor protein prothymosin-alpha.  Exhibiting a variety of immunoregulating properties, thymosin-alpha-1 induces differentiation of murine T-cell precursors and human thymocytes and the terminal differentiation of functionally immature cord blood lymphocytes and induces production of IL-2, high affinity IL-2 receptors, and B-cell growth factors by peripheral blood mononuclear cells. T-helper and cytotoxic/suppressor T-cell populations are targets of thymosin activity. Thymosin-alpha-1 has been shown to increase the efficiency of antigen presentation by macrophages and to be an endogenous modulator of alpha-thrombin activity. (NCI04)
C1254	Tiazofurin	Inosine_5-Phosphate_Dehydrogenase_Inhibitor|Purine_Antagonist	Tiazofurin|2-.beta.-D-Ribofuranosyl-4-thiazolecarboxamide|2-.beta.-D-Ribofuranosylthiazole-4-carboxamide|2-Beta-D-ribofuranosyl-4-thiazolecarboxamide|2-Beta-D-ribofuranosylthiazole-4-carboxamide|4-Thiazolecarboxamide, 2-.beta.-D-ribofuranosyl- (9CI)|4-Thiazolecarboxamide, 2-Beta-D-ribofuranosyl- (9CI)|Riboxamide|tiazofurin	A synthetic nucleoside analogue with antineoplastic activity. Tiazofurin (TR) is anabolized intracellularly to an analogue of NAD, tiazole-4-carboxamide adenine dinucleotide (TAD), a potent inhibitor of IMP dehydrogenase (IMPDH); IMPDH is the rate-limiting enzyme for de novo purine synthesis. Inhibition of IMPDH results in reduced levels of guanylates, resulting in the inhibition tumor cell growth in vitro and in vivo. (NCI04)
C1255	Tin_Ethyl_Etiopurpurin	Photosensitizing_Agent	Tin Ethyl Etiopurpurin|Purlytin|SnET2|Tin Etiopurpurin|Tin, (Ethyl Tetramethyl-20-phorbinecarboxylato(2-)-N23,N24,N25,N26)-, (SP-4-2)|tin ethyl etiopurpurin	A synthetic purpurin with photosensitizing activity.  Tin ethyl etiopurpurin preferentially accumulates in tumor cells due to an increased rate of metabolism. Upon exposure to a light source, this agent absorbs light, forming an extended high energy conformational state that produces high quantum yields of singlet oxygen with local cytotoxic effects. (NCI04)
C1256	Toremifene	Selective_Estrogen_Receptor_Modulator	Toremifene|(Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine|(Z)-4-Chloro-1,2-diphenyl-1[4-[2-(N,N-dimethylamino)ethoxy]phenyl]-1-butene|toremifene	A nonsteroidal triphenylethylene antiestrogen.  Chemically related to tamoxifen, toremifene is a selective estrogen receptor modulator (SERM).  This agent binds competitively to estrogen receptors, thereby interfering with estrogen activity.  Toremifene also has intrinsic estrogenic properties, which are manifested according to tissue type or species. (NCI04)
C1257	Treosulfan	Alkylsulfonate_Compound	Treosulfan|(S-(R*,R*))-1,2,3,4-butanetetrol,1,4-dimethanesulfonate|1,2,3, 4-Butanetetrol, 1,4-dimethanesulfonate, [R-(R*,S*)]-|Dihydroxybusulfan|Ovastat|Tresulfon|treosulfan	A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called alkylating agents.
C1258	Triazinate	Dihydrofolate_Reductase_Inhibitor|Folate_Antagonist	Triazinate|BAF|Baker's Antifol|Baker's Antifol soluble|Baker's Antifolate|Bakers Antifol|Bakers Antifolate|Benzenesulfonyl fluoride, 3-chloro-4-[4-[2-chloro-4-(4, 6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)phenyl]butyl]-, monoethanesulfonate (9CI)|Ethanesulfonic Acid Compound|Ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4, 6-diamino-2, 2-dimethyl-s-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride (1:1) (8CI)|Ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2, 2-dimethyl-s-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride|Ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3, 5-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride (1:1) (9CI)|NSC 139105|NSC-127755|Soluble Baker's Antifol|Triazine Antifol|alpha-(2-chloro-4-(4,6-diamino-2,2-dimethyl-s-trizin-1(2H)-yl)phenoxy)-N,N-dimethyl-m-toluamide ethanesulfonic acid|benzenesulfonyl fluoride, 3-chloro-4-[4-[2-chloro-4-(4, 6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)phenyl]butyl]-, monoethanesulfonate (9CI)|ethanesulfonic acid compound with 3-((2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3,5-triazin-1(2H)-yl)phenoxy)methyl)-N,N-dimethylben zamide (1:1)|ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4, 6-diamino-2, 2-dimethyl-s-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride (1:1)(8CI)|ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2, 2-dimethyl-s-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride|ethanesulfonic acid, compd. with 3-chloro-4-[4-[2-chloro-4-(4,6-diamino-2,2-dimethyl-1,3, 5-triazin-1(2H)-yl)phenyl]butyl]benzenesulfonyl fluoride (1:1)(9CI)	A synthetic dihydrotriazine derivative with antineoplastic properties.  As an antifolate agent related to methotrexate (MTX), triazinate inhibits the enzyme dihydrofolate reductase (DHFR), resulting in decreased tetrahydrofolate production and interference with thymidylate synthesis.  Unlike MTX, this agent is not converted to polyglutamate forms. Triazinate also inhibits the transport of folates and may be selectively toxic to MTX-resistant tumor cells. (NCI04)
C1259	Tributyl_Phosphate	Organo-Metallic_Phosphorus_Boron_Derivatives	Tributyl Phosphate|Tributyl phosphate	Tri-n-butyl phosphate, Bu3-P, TBP.  Industrial chemical; used as a plasticizer, in hydraulic fluid, as a solvent and extractant for metal ions, and as a heat exchange agent.
C1260	Tributyrin	Differentiation_Inducer	Tributyrin|1,2,3-Propanetriyl Butanoate|1,2,3-Tributyrylglycerol|Butanoic Acid 1,2,3-Propanetriyl Ester|Butanoic Acid, 1,2,3-Propanetriyl Ester|Butyryl Triglyceride|Glyceryl Tributyrate|Glyceryl tributyrate|tributyrin	A triglyceride drug that may inhibit cell growth and induce cell differentiation. Differentiating agents may be effective in changing cancer cells back into normal cells.
C1261	Trichostatin_A	Antifungal_Agent|Histone_Deacetylase_Inhibitor	Trichostatin A|(2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide	A natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces.  Trichostatin A (TSA) reversibly and specifically inhibits histone deacetylases, resulting in hyperacetylation of core histones which modulate chromatin structure.  The increase in histone acetylation promotes selective gene transcription and the inhibition of tumor growth.  This agent is a potent inducer of tumor cell growth arrest, differentiation and apoptosis in a variety of transformed cells in culture and in tumor-bearing animals. (NCI04)
C1262	Triciribine_Phosphate	Amidophosphoribosyltransferase_Inhibitor|Inosine_Monophosphate_Dehydrogenase_Inhibitor|Purine_Antagonist	Triciribine Phosphate|1, 5-Dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)-1,4,5, 6,8-pentaazaacenaphthylen-3-amine|1, 5-dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)-1,4,5, 6,8-pentaazaacenaphthylen-3-amine|1,4, 5,6,8-Pentaazaacenaphthylen-3-amine, 1, 5-dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)- (9CI)|1,4, 5,6,8-pentaazaacenaphthylen-3-amine, 1, 5-dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)- (9CI)|1,4,5,6, 8-Pentaazaacenaphthalen-3-amine, 1, 5-dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)-|1,4,5,6, 8-pentaazaacenaphthalen-3-amine, 1, 5-dihydro-5-methyl-1-(5-O-phosphono-.beta.-D-ribofuranosyl)|3-Amino-1, 5-dihydro-5-methyl-1-.beta.-D-ribofuranosyl-1,4,5,6, 8-pentaazaacenaphthylene 5'-(dihydrogen phosphate)|3-amino-1, 5-dihydro-5-methyl-1-.beta.-D-ribofuranosyl-1,4,5,6, 8-pentaazaacenaphthylene 5'-(dihydrogen phosphate)|Triciribine|Tricyclic Nucleoside 5'-Phosphate|Tricycloside Phosphate	A tricyclic nucleoside with potential antineoplastic activity. As a purine analog, triciribine phosphate inhibits the enzymes amidophosphoribosyltransferase and inosine monophosphate dehydrogenase, resulting in decreased purine nucleotide biosynthesis, decreased DNA and protein synthesis, and cell cycle arrest.  This agent may also exhibit antiviral activity. (NCI04)
C1263	Trilostane	Anti-Adrenal|Steroidal_Aromatase_Inhibitor|_3-Hydroxysteroid_Dehydrogenase_Inhibitor	Trilostane|(4Alpha,5alpha,17beta)-4,5-epoxy-3,17-dihydroxyandrost-2-ene-2-carbonitrile|2Alpha-cyano-4alpha,5alpha-epoxyandrostan-17beta-ol-3-one|4,5-Epoxy-17-hydroxy-3-oxoandrostane-2-carbonitrile|Desopan|Modrastane|Modrenal|WIN 24,540|WIN 24540	A synthetic derivative of androstane with adrenocortical suppressive properties.  Trilostane reversibly inhibits 3 beta-hydroxysteroid dehydrogenase delta 5-4 isomerase in the adrenal cortex, resulting in the decreased synthesis of mineralocorticoids and glucocorticoids and the decreased conversion of pregnenolone to progesterone. (NCI04)
C1264	Trimethylcolchicinic_Acid	Tubulin_Binding_Agent	Trimethylcolchicinic Acid|Desacetyl Colchicine D-tartrate|Methyl Ether|TMCA|Trimethylcolchicinic Acid Methyl Ether d-tartrate|Trimethylcolchicinic acid	A colchicine analog with potential antineoplastic activity.  Trimethylcolchicinic acid binds to tubulin, inhibiting its polymerization into microtubules and preventing cell division. (NCI04)
C1265	Trimetrexate_Glucuronate	Trimetrexate	Trimetrexate Glucuronate|2,4-Diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline mono-D-glucuronate|Neutrexin|TRIMETREXATE GLUCURONATE|trimetrexate glucuronate	A drug that belongs to the family of drugs called antimetabolites. It is used in the treatment of pneumocystis carinii pneumonia and is being studied in the treatment of cancer.
C1266	Trioxifene	Selective_Estrogen_Receptor_Modulator	Trioxifene|(3,4-Dihydro-2-(4-methoxyphenyl)-1-naphthalenyl)(4-(2-(1-pyrrolidinyl)ethoxy)phenyl) Methanone	A nonsteroidal selective estrogen receptor modulator (SERM) studied in advanced breast cancer.  Trioxifene competitively inhibits the binding of estradiol to estrogen receptor alpha (ER alpha), resulting in ER alpha-mediated gene expression.  Clinical development of trioxifene has not proceeded due to lack of superior results over tamoxifen and side effect profile. (NCI)
C1267	Triptorelin	Anti-Androgen|Gonadotropin-Releasing_Hormone_Analog	Triptorelin|6-D-Tryptophan-LH-RH|6-D-Tryptophanluteinizing Hormone-releasing Factor|AY-25650|CL-118,532|Decapeptyl|Detryptoreline|triptorelin	A hormonal anticancer drug that belongs to the family of drugs called gonadotropin-releasing analogues.
C1268	Trofosfamide	Nitrogen_Mustard_Compound	Trofosfamide|2-[bis(2-chloroethyl)amino]-3-(2-chloroethyl)tetrahydro-2H-1,3,2-oxaphosphorine 2-oxide|2H-1,3,2-Oxazaphosphorin-2-amine, N,N, 3-tris(2-chloroethyl)tetrahydro-, 2-oxide, (+)-|2H-1,3,2-Oxazaphosphorin-2-amine, N,N, 3-tris(2-chloroethyl)tetrahydro-, 2-oxide, (-)-|A-4828|Genoxal Trofosfamida|Ixoten|N,N,3-tris(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide|N,N,N'-tris(2-chloroethyl)-N',O-propylene phosphoric acid ester diamide|NSC-109723|Trilophosphamide|Trofosfamid|Trophosphamide|Z 4828|Z-4828	An alkylating antineoplastic agent; cyclophosphamide analog.
C1269	TAG-72_Antigen	Tumor_Antigen	TAG-72 Antigen|Antitumor-Associated Glycoprotein 72|TAG-72|TAG-72 antigen	A protein/sugar complex found on the surface of many cancer cells, including breast, colon, and pancreatic cells.
C1270	Adozelesin	DNA_Minor_Groove_Binding_Agent|Miscellaneous_Alkylating_Agent	Adozelesin|U-73,975	An alkylating agent that bind to the DNA minor groove in a sequence-specific manner and form covalent adducts with adenines, resulting in the inhibition of DNA replication and induction of apoptosis. (NCI04)
C1271	_7-Hydroxystaurosporine	Multidrug_Resistance_Modulator|Protein_Kinase_C_Inhibitor|Thymidylate_Synthase_Inhibitor	7-Hydroxystaurosporine|(+)-UCN-01|2,3,9,10,11,12-Hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)-8,12-epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)triinden-1-one|7-Hydroxy-staurosporine|8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo[a, g]cyclonona[cde] Trinden-1-one, 2,3,9,10,11, 12-hexahydro-3-hydroxy-9-methoxy-8-methyl-10-(methylamino)|UCN-01|UCN-01 + S phase chemotherapeutics	A synthetic derivative of staurosporine with antineoplastic activity. 7-hydroxystaurosporine inhibits many phosphokinases, including the serine/threonine kinase AKT, calcium-dependent protein kinase C, and cyclin-dependent kinases. This agent arrests tumor cells in the G1/S of the cell cycle and prevents nucleotide excision repair by inhibiting the G2 checkpoint kinase chk1, resulting in apoptosis. (NCI04)
C1272	Therapeutic_Vascular_Endothelial_Growth_Factor	Therapeutic_Platlet-Derived_Growth_Factor	Recombinant Vascular Endothelial Growth Factor|VEGF|VPF|Vascular Endothelial Growth Factor|Vascular Permeability Factor|rhuVEGF|vascular endothelial growth factor	A recombinant therapeutic agent which is chemically identical to or similar to endogenous vascular endothelial growth factor (VEGF).  Produced by a wide variety of cell types, endogenous VEGF is a homodimeric, glycosylated protein that is a highly specific mitogen for vascular endothelial cells; significantly influences vascular permeability; appears to play a role in neovascularisation under physiological conditions; is a potent chemoattractant; has pro-coagulatory activities; and is hypoxia-inducible.  Therapeutic VEGF may be used to induce angiogenesis in the treatment of ischemic conditions and may have a role in stimulating nerve regeneration. (NCI04)
C1273	Vindoline	Multidrug_Resistance_Modulator	Vindoline|VINDOLINE	An indole alkaloid that exhibits antimitotic activity by inhibiting microtubule assembly. (NCI)
C1274	Vinepidine	Vinca_Alkaloid_Compound	Vinepidine
C1275	Vinorelbine	Vinca_Alkaloid_Compound	Vinorelbine|3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastine|5'-Nor-Anhydrovinblastine|Dihydroxydeoxynorvinkaleukoblastine|nor-5'-Anhydrovinblastine|vinorelbine	A semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. This agent may also interfere with amino acid, cyclic AMP. and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.
C1276	Vinzolidine	Vinca_Alkaloid_Compound	Vinzolidine	Orally active, semisynthetic vinca alkaloid.
C1277	Wortmannin	Phosphatidylinositide_3-Kinase_Inhibitor	Wortmannin|(1 Alpha,11 alpha)-11-(acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan- 3,7,17-trione|(1S,6bR,9aS,11R,11bR)-11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-3H-furo[4,3,2-de]indeno[4,5-h]-2-benzopyran-3,6,9-trione|2-Oxaandrosta-5,8-dieno[6,5,4-bc]furan-3,7,17-trione, 11-(acetyloxy)-1-(methoxymethyl)-, (1.alpha.,11.alpha.)-|SL-2052|WORTMANNIN	A potent fungal metabolite isolated from Penicillium wortmannin that selectively inhibits phosphatidylinositol 3-kinase and affects the signal transduction pathway. (NCI)
C1278	Venlafaxine	Antidepressant_Agent	Venlafaxine|venlafaxine	A synthetic phenethylamine bicyclic derivative with antidepressant activity. Venlafaxine and its active metabolite, O-desmethylvenlafaxine (ODV), are potent inhibitors of neuronal serotonin and norepinephrine reuptake and weak dopamine reuptake inhibitors.  This agent may reduce hormone-related vasomotor symptoms. (NCI04)
C1279	Pingyangmycin	Bleomycin_Antibiotic|Endothelial_Cell_Inhibitor	Pingyangmycin|Bleomycetin|Bleomycin A5|N1-(3-((4-Aminobutyl)amino)propyl)bleomycinamide|Zhengguangmycin A5	The naturally-occurring bleomycin antineoplastic antibiotic isolated from the bacterium Streptomyces pingyangensisn.  Pingyangmycin induces tumor cell apoptosis, possibly via a mechanism mediated by the mitogen-activated protein kinase (MAPK) pathway. (NCI04)
C1280	Zinc_Sulfate	Miscellaneous_Chemoprotective_Agent|Nutritional_Supplement	Zinc Sulfate|Zinc sulfate|zinc sulfate	A salt of the essential trace metal zinc. Zinc is involved in tissue repair and is an important constituent of some proteins, including those involved in taste and smell. Zinc sulfate supplementation may prevent radiation-induced aguesia. (NCI04)
C1281	Biohazard	Industrial_Product	Biohazardous Substance|Biohazard|Biohazard Substance	A biological or chemical substance that exerts toxic or pathologic effects on living entities.
C1282	Carboplatin	Platinum_Compound	Carboplatin|(SP-4-2)-diammine[1,1-cyclobutanedicarboxylato(2--)-O,O']platinum|1,1-cyclobutanedicarboxylic acid platinum complex|Blastocarb|CBDCA|Carboplat|Carboplatin Hexal|Carboplatino|Carbosin|Carbosol|Carbotec|Cis-Diammine(cyclobutane-1,1-dicarboxylato)platinum|Displata|Ercar|JM-8|Nealorin|Novoplatinum|Paraplat|Paraplatin|Paraplatin AQ|Paraplatine|Platinwas|Ribocarbo|carboplatin|cis-diammine(1,1-cyclobutanedicarboxylato) platinum(II)|cis-diammine(cyclobutanedicarboxylato)platinum II|platinum, diammine(1,1-cyclobutanedicarboxylato(2-))-, (SP-4-2)	A second-generation platinum compound with a broad spectrum of antineoplastic properties.  Carboplatin contains a platinum atom complexed with two ammonia groups and a cyclobutane-dicarboxyl residue.  This agent is activated intracellularly to form reactive platinum complexes that bind to nucleophilic groups such as GC-rich sites in DNA, thereby inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links.  These carboplatin-induced DNA and protein effects result in apoptosis and cell growth inhibition.  This agent possesses tumoricidal activity similar to that of its parent compound, cisplatin, but is more stable and less toxic. (NCI04)
C1283	Therapeutic_Cytokine	Biological_Agent|Biological_Response_Modifier	Recombinant Cytokine|Cytokines|cytokines	A class of substances that are produced by cells of the immune system and can affect the immune response. Cytokines can also be produced in the laboratory by recombinant DNA technology and given to people to affect immune responses.
C1284	Dextran_Sulfate_Sodium	Anti-HIV_Agent	Dextran Sulfate Sodium|Dextran Sulfate	The sodium salt of sulfuric acid esters of glucose polymers.  Dextran is produced by the action of the bacterium Leuconostoc mesenteroides and of other microorganisms on sucrose.  This agent possesses strong hydrophilic properties and binds to various membranes, particularly those with a positive charge. (NCI04)
C1285	Endothelin-1	Signaling_Protein	Endothelin-1|EDN1|ET-1|Endothelin 1	Endothelin-1, encoded by the EDN1 gene is a potent, 21-amino acid vasoconstrictor peptide produced by vascular endothelial cells. Endothelin-1 inhibits active Na-K transport by inhibiting Na(+)-K(+)-ATPase in intact renaltubular epithelial cells. (From OMIM, PubMed and NCI)
C1286	Therapeutic_Transforming_Growth_Factor-Beta_2	Therapeutic_Transforming_Growth_Factor-Beta	Recombinant Transforming Growth Factor-Beta 2|Cartilage-Inducing Factor-B|Glioblastoma-Derived T-Cell Suppressor Factor|TGF-Beta 2|Transforming Growth Factor-Beta 2	A recombinant agent, which is chemically identical to or similar to the endogenous cytokine transforming growth factor-beta-2 (TGF-beta-2). TGF-beta-2 modulates cell growth and immune function and may promote or inhibit tumor growth, depending on the tumor cell type; this agent may also suppress host immune system recognition of and/or response to tumor cells. (NCI04)
C1287	Recombinant_Granulocyte_Colony_Stimulating_Factor	Therapeutic_Colony_Stimulating_Factor	Recombinant Granulocyte Colony Stimulating Factor|CSF-G/G-CSF|CSF-G/G-CSF (Recombinant Human)|G-CSF|G-CSF (Amgen)|G-CSF/SCF|Granulocyte Colony Stimulating Factor|Lenograstim|granulocyte colony-stimulating factor	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine granulocyte colony-stimulating factor (G-CSF).  Secreted by monocytes, macrophages and neutrophils and other cells after activation, G-CSF stimulates the proliferation and differentiation of hematopoietic progenitor cells committed to the neutrophil/ granulocyte lineage. (NCI04)
C1288	Therapeutic_Granulocyte-Macrophage_Colony-Stimulating_Factor	Therapeutic_Colony_Stimulating_Factor	Recombinant Granulocyte-Macrophage Colony-Stimulating Factor|CSF 39300|CSF 39300/GM-CSF|CSF-GM (Hoechst)|Colony-Stimulating Factor, Granulocyte-Macrophage|GM CSF|GM-CSF|GM-CSF (Schering)|Granulocyte Macrophage Colony-Stimulating Factor|Granulocyte-Macrophage Colony Stimulating Factor|Hematopoietic Colony-stimulating Factors|Leukine|Molgramostin|Sargramostim	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous glycoprotein cytokine growth factor granulocyte-macrophage colony stimulating factor (GM-CSF). Therapeutic GM-CSF induces the clonal expansion and differentiation of progenitor blood cells and stimulates the cytotoxicity of monocytes and neutrophils, thereby restoring immune function and host antitumor immune responses and stimulating engraftment of transplanted bone marrow tissue. (NCI04)
C1289	Therapeutic_Interleukin-8	Therapeutic_Alpha_Chemokine	Recombinant Interleukin-8|Anionic Neutrophil Activating Peptide|Anionic Neutrophil-Activating Peptide|CXCL8|GCP-IL-8|Granulocyte Chemotactic Peptide Interleukin 8|IL-8|Interleukin-8|Leukocyte Adhesion Inhibitor|MDNCF|Macrophage-Derived Chemotactic Factor|Monocyte-Derived Neutrophil Chemotactic Factor|Monocyte-Derived Neutrophil-Activating Peptide|NAP-1|Neutrophil Activation Factor|Neutrophil Activation Peptide|Neutrophil Chemotactic Factor	A member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types including monocytes, macrophages, T-lymphocytes, fibroblasts, endothelial cells, and keratinocytes. It functions as a chemoattractant, and is also a potent angiogenic factor. (from LocusLink)
C1290	Recombinant_Macrophage_Colony-Stimulating_Factor	Therapeutic_Colony_Stimulating_Factor	Recombinant Macrophage Colony-Stimulating Factor|CSF-M|Colony Stimulating Factor 1|Human Macrophage-CSF|M-CSF|Macrophage Colony Stimulating Factor	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous protein cytokine mononuclear phagocyte colony-stimulating factor (M-CSF).  Synthesized endogenously by mesenchymal cells, M-CSF stimulates the survival, proliferation, and differentiation of hematopoietic cells of the monocyte-macrophage series and can reverse treatment-related neutropenias. Recombinant M-CSF may also enhance antigen presentation and activate antitumoral cytotoxic T-cells. (NCI04)
C1291	Antisense_Agent	Biological_Agent	Antisense Agent|Antisense Agents|Antisense Oligonucleotides|Gene Expression Inhibitor	Antisense Oligonucleotides, short synthetic segments of DNA or RNA, designed with a sequence complimentary to a specific mRNA that target and bind with mRNA, causing inhibition of translation or overexpression of the protein encoded by the mRNA.
C1292	Ribozyme	Functional_RNA	Ribozyme|Catalytic RNA|RNA, Catalytic	RNA that contains an intron sequence which has an enzyme-like catalytic activity. This intron sequence has been shown to fold up to form a complex surface that can function like an enzyme in reactions with other RNA molecules and thus synthesize new molecules even in the absence of protein. Synthetic ribozymes can be engineered to specifically cleave a target RNA sequence causing expression down regulation.
C1293	Therapeutic_Transforming_Growth_Factor-Beta_1	Therapeutic_Transforming_Growth_Factor-Beta	Recombinant Transforming Growth Factor-Beta 1|TGFbeta1	A recombinant form of the endogenous Transforming Growth Factor-Beta 1, a protein involved with the regulation of cell proliferation and differentiation.
C1294	Thymopentin	Immunostimulant	Thymopentin|Imunox|Mepentil|N-(N-(N-(N(2)-L-Arginyl-L-Lysyl)-L-alpha-Aspartyl)-L-Valyl)-L-Tyrosine|N-[N-[N-(N{2}-L-Arginyl-L-lysyl)-L-alpha-aspartyl]-L-valyl]-L-tyrosine|Sintomodulina|Timunox	A synthetic pentapeptide which is the active site of the naturally occurring hormone thymopoietin with immunomodulating properties. Thymopentin enhances the production of thymic T cells and may help restore immunocompetence in immunosuppressed subjects. This agent also augments the effects of ionizing radiation by arresting cancer cells in the G2/M phase of the cell cycle. (NCI04)
C1295	Virginiamycin_M1	Virginiamycin	Virginiamycin M1|OSTREOGRYCIN A|VERNAMYCIN A|mikamycin A|ostreogrycin A|pristinamycin IIA|staphylomycin M1|streptogramin A|vernamycin A|virginiamycin factor M1	A streptomycin A-related cyclic depsipeptide isolated from the bacterium Streptomyces virginiae and other Streptomyces bacterial species.  Virginiamycin M1 binds to and inhibits assembly of 50S and 30S ribosomes, thereby preventing protein synthesis. (NCI04)
C1296	Virginiamycin_S1	Virginiamycin	Virginiamycin S1|Pristinamycin IA|Staphylomycin S|Streptogramin B|Virginiamycin Factor S	A streptomycin B-related cyclic depsipeptide isolated from the bacterium Streptomyces virginiae and other Streptomyces bacterial species.  Virginiamycin S1 binds to and inhibits the formation of 50S ribosomes, thereby preventing protein synthesis. (NCI04)
C1297	_8-Oxo-2_Deoxyguanosine	Nucleoside	8-Oxo-2'-Deoxyguanosine|8-Oxo-dG	A type of altered DNA base caused by oxidative DNA damage.
C1298	TNP-470	Endothelial_Cell_Inhibitor	TNP-470|(3R,4S,5S,6R)-5-Methoxy-4- [(2R,3R)-2-methyl-3-(3-methyl-2-butenyl) -oxiranyl]-1-oxaspiro [2,5] oct-6-yl(chloroacetyl) Carbamate|5-Methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)-1-oxaspiro(2,5)oct-6-yl(chloroacetyl)carbamate|AGM-1470|O-(Chloroacetylcarbamoyl)fumagillol|TNP-470 (Fumagillin)|[3R-[3alpha,4alpha(2R*,3R*),5beta,6beta]]-5-Methoxy-4-[2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl (chloroacetyl)carbamate	A drug that belongs to the family of drugs called angiogenesis inhibitors. It prevents the growth of new blood vessels into a solid tumor.
C1299	Disulfonated_Aluminum_Phthalocyanine	Chloroaluminum_Phthalocyanine	Disulfonated Aluminum Phthalocyanine|AlS2Pc|Aluminum Phthalocyanine Disulfonate	An amphiphilic compound that exhibits a direct phototoxic effect, thereby inducing tumor necrosis. (NCI)
C1300	Dolastatin_10	Dolastatin_Compound	Dolastatin 10|B720389K560|Dolastatin-10|L-Valinamide, N,N-dimethyl-L-valyl-N-[2-methoxy-4-[2-[1- methoxy-2-methyl-3-oxo-3-[[2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-(1-methylpropyl)-4-oxobutyl]-N-methyl-, [2S-[1[1R*(R*),2S*],2R*[1S*,2S*,3(R*)]]]|dolastatin 10	A pentapeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity.  Binding to tubulin, Dolastatin 10 inhibits microtubule assembly, resulting in the formation of tubulin aggregates and inhibition of mitosis.  This agent also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers. (NCI04)
C1301	Esperamicin_A1	Enediyne_Antitumor_Antibiotic	Esperamicin A1	An enediyne antineoplastic antibiotic hybrid containing an anthranilate moiety.  Esperamicin A1 is isolated from the bacterium Actinomadura verrucosospora.  The anthranilate component of esperamicin A1 intercalates DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-stranded breaks in DNA and apoptosis. (NCI04)
C1302	Therapeutic_I309	Therapeutic_Beta_Chemokine	Recombinant I309|CCL1|I309	A recombinant form of human I-309, an inflammatory CXC cytokine secreted by activated T lymphocytes that appears to be an inducer of angiogenesis.(NCI)
C1303	Therapeutic_Interleukin-11	Therapeutic_Interleukin	Recombinant Interleukin-11|Adipogenesis Inhibitory Factor|IL-11|Inform|Interleukin 11|Interleukin-11|Interleukin-11-Recombinant|Neumega|Oprelvekin|Oprelvekin (Interleukin 11)|Recombinant Human Interleukin-11|Therapeutic Interleukin-11|interleukin-11|rhIL-11	(in-ter-LOO-kin) IL-11. A type of biological response modifier (a substance that can improve the body's natural response to infection and disease) that stimulates immune response and may reduce toxicity to the gastrointestinal system resulting from cancer therapy. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases. Also called oprelvekin.
C1304	PEG-interleukin-2	Therapeutic_Interleukin-2	PEG-interleukin-2|PEG-IL-2|PEG-IL-2(CT)|Polyethylene Glycol-Modified Recombinant Interleukin-2	A complex of polyethylene glycol conjugated with human recombinant cytokine interleukin-2 (IL-2) with antineoplastic activity. PEG-interleukin-2 induces natural killer (NK) cell activity and the production of interferon-gamma (IFN-gamma), and enhances T cell-mediated cytotoxicity. Pegylation of IL-2 protects the cytokine from degradation. (NCI04)
C1305	Erbstatin_Analog	Tyrosine_Kinase_Inhibitor	Methyl 2,5-dihydroxycinnamate|3-(2,5-Dihydroxyphenyl)-2-propenoic Acid Methyl Ester|ALX-270-098|Methyl-2,5-dihydroxycinnamate	A cell-permeable analog of erbstatin, a compound isolated from Streptomyces that inhibits the autophosphorylation of epidermal growth factor receptor.  Erbstatin analogue competitively inhibits epidermal growth factor receptor-associated tyrosine kinase, inhibiting the activation of v-abl tyrosine kinase.  In addition, this agent has induced apoptosis in mouse thymocytes and inhibits the G2/M phase of the cell cycle. (NCI)
C1306	O_6_Benzylguanine	Chemo_Immunostimulant_Adjuvant|Multidrug_Resistance_Modulator|_06-Alkylguanine-DNA_Alkyltransferase_Inhibitor	O(6)-Benzylguanine|06-Benzyl Guanine|06-Benzylguanine|6-O-Benzylguanine|O(6)-benzylguanine|O-6 Benzylguanine|O-6-Benzylguanine|O6-Benzylguanine	A drug that may improve the response of cancer cells to chemotherapy.
C1307	Recombinant_Pleiotrophin	Therapeutic_Heparin-Binding_Neurotrophic_Factor	Recombinant Pleiotrophin|HARP|HBGF-8|HBNF|Heparin Affin Regulatory Peptide|Heparin-Binding Growth Factor-8|Heparin-Binding Neurotrophic Factor|OSF-1|Osteoblast Specific Factor 1|Pleiotrophin|Recombinant Heparin-Binding Neurotrophic Factor	A recombinant form of the heparin-binding cytokine pleiotrophin.  Developmentally regulated, pleiotrophin functions as a growth factor during embryogenesis and the neonatal period, contributing to trophoblast formation, organ development, bone formation, and early brain development by inducing the differentiation and proliferation of neuronal tissue.  Expressed in certain tumor cell types, this agent may stimulate tumor cell growth, angiogenesis, and metastasis. (NCI04)
C1308	Poly_RGD	Anti-Adhesion_Agent	Poly (RGD)	A synthetic polypeptide based on the arg-gly-asp (RGD) sequence present in some cell adhesion molecules.  Displays antimetastatic activity in model systems.
C1309	Therapeutic_Fibroblast_Growth_Factor_4	Therapeutic_Fibroblast_Growth_Factor	Recombinant Fibroblast Growth Factor 4|FGF4|Fibroblast Growth Factor 4|HBGF-4|Transforming Protein KS3	A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 4 (FGF-4). Therapeutic FGF-4 induces vascular permeability, angiogenesis, and arteriogenesis and has potential uses in the treatment of peripheral vascular disease. (NCI04)
C1310	Ro_31-8220	Protein_Kinase_C_Inhibitor	Ro 31-8220|Bisindolylmaleimide IX Methanesulfonate|Ro-31-8220	A methanesulfonate salt form, a staurosporine analog that inhibits protein kinase C and induces apoptosis. (NCI)
C1311	Tacrolimus	Immunosuppressant	Tacrolimus|FK 506|Hexadecahydro-5,19-dihydroxy-3-[2-(4-hydroxy-3-methoxycyclohexyl)-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetramethyl-8-(2-propenyl)-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone|TACROLIMUS|tacrolimus	A drug used to help reduce the risk of rejection by the body of organ and bone marrow transplants.
C1312	Generic_Drug	Medication	Generic Drug|GEN|Generic|generic	Drugs that are manufactured and distributed by various pharmaceutical companies under their generic name or a brand name and do not have patent protection.(NCI)
C1313	Misoprostol	Cytoprotective_Agent	Misoprostol|(11alpha,13E)-(+-)-11,16-Dihydroxy-16-methyl-9-oxo-prost-13-en-1-oic Acid Methyl Ester|Cytotec|Methyl (11alpha,13E)-11,16-Dihydroxy-16-methyl-9-oxoprost-13-en-1-oate|SC-29333|misoprostol	A radioprotective agent that belongs to the family of drugs called prostaglandins.
C1314	Trimetrexate	Dihydrofolate_Reductase_Inhibitor|Folate_Antagonist	Trimetrexate|2,4-Quinazolinediamine, 5-methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-|5-Methyl-6-[[(3,4,5-trimethoxyphenyl)amino]methyl]-2,4-quinazolinediamine|CI-898|NSC 249008|TMQ|Trimexate	A methotrexate derivative with potential antineoplastic activity.  Trimetrexate inhibits the enzyme dihydrofolate reductase, thereby preventing the synthesis of purine nucleotides and thymidylate, with subsequent inhibition of DNA and RNA synthesis.  Trimetrexate also exhibits antiviral activity. (NCI04)
C1315	Aflatoxin_B1	Aflatoxin	Aflatoxin B1
C1316	_6-Hydroxydopamine	Neurotoxin|Unclassified_Chemotherapy_Agent	6-Hydroxydopamine|2,4,5-Trihydroxyphenethylamine|5-(2-Aminoethyl)-1,2,4-benzenetriol|6-OHDA|Oxidopamine	An analogue of the neurotransmitter dopamine with potential antineoplastic activity.  6-Hydroxydopamine depletes noradrenergic stores of dopamine in nerve endings, produces cytolytic free-radicals, resulting in reduced level of dopamine in the brain.  Experimentally, 6-Hydroxydopamine is used to induce CNS and sympathetic neural lesions that model aging and various nervous disorders.
C1317	Bupropion	Antidepressant_Agent	Bupropion Hydrochloride|(+-)-1-(3-Chlorophenyl)-2-[(1,1-dimethylethyl)amino]-1-propanone Hydrochloride|1-Propanone, 1-(3-Chlorophenyl)-2-((1,1-dimethylethyl)amino)-|Amfebutamone|BUPROPION HYDROCHLORIDE|BW 323U66|Bupropion|Bupropion HCl|Wellbutrin|Zyban|bupropion	A substance that is used to treat depression, and to help people quit smoking.  It belongs to the family of drugs called antidepressants.
C1318	Lithium_Carbonate	Miscellaneous_Chemoprotective_Agent	Lithium Carbonate|Eskalith|LITHIUM CARBONATE|Lithane|Lithium|Lithium carbonate|Lithobid|Lithonate|Lithotabs
C1319	Leuprolide	Gonadotropin-Releasing_Hormone_Analog	Leuprolide Acetate|6-D-Leucine-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor (Pig)|6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig)|A-43818|Abbott 43818|Abbott-43818|Carcinil|Enanton|Enantone|Enantone-Gyn|Ginecrin|LEUP|LEUPROLIDE ACETATE|Leuplin|Leuprolide|Leuprorelin|Leuprorelin Acetate|Lucrin|Lucrin Depot|Lupron|Lupron Depot|Lupron Depot-3 Month|Lupron Depot-4 Month|Lupron Depot-Ped|Procren|Procrin|Prostap|TAP-144|Trenantone|Uno-Enantone|Viadur|leuprolide	A drug that belongs to a family of drugs called gonadotropin-releasing hormone analogues. It is used to block hormone production in the ovaries or testicles.
C1320	Therapeutic_Interleukin_10	Therapeutic_Interleukin	Recombinant Interleukin 10|B cell-derived T cell growth factor|CSIF|CSIF-10|Cytokine Synthesis Inhibitory Factor|IL-10|Interleukin-10	A recombinant form of the endogenous cytokine, interleukin-10 exhibiting anti-tumor activity.  Recombinant interleukin-10 mimics interleukin-10 activity by inhibiting production of cytokines by activated T cells, increasing B-cell viability, and inducing expression of class II major histocompatibility complex genes. (NCI)
C1321	Monoclonal_Antibody_OKT3	Monoclonal_Antibody	Monoclonal Antibody OKT3|Anti CD3|Anti-CD3 Monoclonal Antibody OKT3|MoAb OKT3|Muromonab-CD3 Monoclonal Antibody|Orthoclone|muromonab-CD3 monoclonal antibody	A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.
C1322	Lipooxygenase_Inhibitor	Enzyme_Inhibitor	Lipooxygenase Inhibitor
C1323	Cyclooxygenase_Inhibitor	Chemopreventive_Agent|Enzyme_Inhibitor|Miscellaneous_Angiogenesis_Inhibitor|Nonsteroidal_Antiinflammatory_Drug	Cyclooxygenase Inhibitor
C1324	Therapeutic_Interleukin-9	Therapeutic_Interleukin	Recombinant Interleukin-9|IL-9|Interleukin 9|P40 T-Cell Growth Factor	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-9 (IL-9). Produced by CD4+ lymphocytes, IL-9 stimulates the proliferation of T-helper cells and the growth of mast cells and megakaryoblasts.  This agent also enhances the growth of some leukemia cell lines and may play a role in the pathogenesis of Hodgkin's disease and large cell anaplastic lymphoma. (NCI04)
C1325	HIV_Vaccine	Vaccine	HIV Vaccine|AIDS Vaccines|HIV/AIDS Vaccines
C1326	Doxorubicin_Hydrochloride	Doxorubicin	Doxorubicin Hydrochloride|14-Hydroxydaunorubicin Hydrochloride|3-Hydroxyacetyldaunorubicin Hydrochloride|5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8, 9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-, hydrochloride, (8S-cis)- (9CI)|5,12-Naphthacenedione, 10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-,hydrochloride, (8S-cis)-(9CI)|ADM|ADRIAMYCIN, HYDROCHLORIDE|Adriacin|Adriamycin|Adriamycin Hydrochloride|Adriamycin PFS|Adriamycin RDS|Adriamycin hydrochloride|Adriamycine|Adriblastina|Adriblastine|Adrimedac|Chloridrato de Doxorrubicina|DOX|DOXO-CELL|DOXORUBICIN HYDROCHLORIDE|Doxolem|Doxorubicin hydrochloride|Doxorubicin.HCl|Doxorubin|FI 106|FI-106|Farmiblastina|L-Lyxo-hexopyranoside, 3b-glycol-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-methoxy-6,11-dioxo-1a-naphthacenyl 3-amino-2,3,6-trideoxy-.alpha.-, hydrochloride|Rubex	The hydrochloride salt of the anthracycline antineoplastic antibiotic doxorubicin.  Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. (NCI04)
C1327	Antiplatelet_Agent	Adjuvant	Antiplatelet Agent	An agent that inhibits platelet aggregation and reduces coagulation in the circulatory system. (NCI)
C1328	BCG	Vaccine_Adjuvant	BCG|BCG (Connaught)|BCG (Pasteur)|Bacillus Calmette Guerin|Bacillus Calmette-Guerin|Bacillus Calmette-Guerin (BCG)|Mycobacterium bovis (Strain BCG)	An attenuated strain of Mycobacterium bovis with non-specific immunoadjuvant and immunotherapeutic properties. Although the mechanism of its anti-tumor activity is unclear, immunization with BCG (Bacillus Calmette-Guerin) likely activates a Th1 cytokine response that includes induction of interferon.  Vaccination with BCG may be immunoprotective against infection with Mycobacterium tuberculosis. (NCI04)
C1329	Cloning_Vector	Deoxyribonucleic_Acid	Cloning Vector|Vector|Vectors|Vectors [Cloning Vectors]	Any DNA molecule capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. They are or are derived from plasmids, bacteriophages, or viruses and are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain genetic markers to facilitate their selective recognition.
C1330	Deoxythymidine	Nucleoside	Deoxythymidine	A pyrimidine nucleoside component of DNA comprised of thymidine linked by its N1 nitrogen to the C1 carbon of deoxyribose.(NCI)
C1331	Epipodophyllotoxin_Compound	Antineoplastic_Plant_Product|Topoisomerase-II_Inhibitor	Epipodophyllotoxin Compound|epipodophyllotoxins	A family of compounds derived from Podophyllum peltatum.  Epipodophyllotoxin Compounds bind to and inhibit topoisomerase II and its function in ligating cleaved DNA molecules, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. (NCI)
C1332	Etidronate	Biphosphonate	Etidronate|(1-Hydroxyethylidene)bisphosphonic Acid|(1-Hydroxyethylidene)diphosphonic Acid|EHDP|Ethane-1-hydroxy-1,1-diphosphonic Acid|Ethane-1-hydroxy-1,1-diphosphonic acid|Etidronic Acid|etidronate	A drug that belongs to the family of drugs called bisphosphonates. Bisphosphonates are used as treatment for hypercalcemia (abnormally high levels of calcium in the blood) and for cancer that has spread to the bone (bone metastases).
C1333	Dexrazoxane	Cardioprotective_Agent|Chelating_Agent	Dexrazoxane|(+)-(S)-4,4'-(1-Methyl-1,2-ethanediyl)di(2,6-piperazinedione)|2, 6-Piperazinedione, 4,4'-propylenedi-, (P)- (8CI)|2,6-Piperazinedione, 4, 4'-(1-methyl-1,2-ethanediyl)bis-, (S)- (9CI)|2,6-Piperazinedione, 4,4'-(1-methyl-1,2-ethanediyl)bis-,(S)-(9CI)|2,6-Piperazinedione, 4,4'propylenedi-,(P)-(8CI)|ADR-529|Dexrazoxane for Inj (Zinecard)|ICRF-187|Razoxane (+)-form|Soluble ICRF (L-Isomer)|Soluble ICRF (L-isomer)|Zinecard|dexrazoxane	A bisdioxopiperazine with antineoplastic activity and cardioprotective properties.  After hydrolysis to an active form that is similar to ethylenediaminetetraacetic acid (EDTA), dexrazoxane chelates iron, thereby preventing the metal-catalyzed formation of reactive oxygen radicals produced by anthracycline antibiotics such as doxorubicin.  This agent also inhibits the catalytic activity of topoisomerase II, resulting in cell growth inhibition. (NCI04)
C1334	Vitamin_B6	B_Vitamin|Miscellaneous_Chemoprotective_Agent	Vitamin B6|PYRIDOXINE|Pyridoxine|Pyridoxine (Vitamin B6)|VIT B6	A water-soluble vitamin essential for metabolism and normal physiological functions and present in three forms: pyridoxine, pyridoxal, and pyridoxamine.  B6 vitamins are converted in vivo to pyridoxal phosphate, a cofactor necessary for the synthesis of amino acids, neurotransmitters, and sphingolipids.  More than 100 enzymes involved in protein metabolism require vitamin B6 as a cofactor. This vitamin is essential to red blood cell, nervous system, and immune systems functions and helps maintain normal blood glucose levels.  Vitamin B6 is found in a wide variety of foods including cereals, beans, meat, poultry, fish, and some fruits and vegetables. (NCI04)
C1335	Aminothiadiazole	Inosine_Monophosphate_Dehydrogenase_Inhibitor	Aminothiadiazole|1,3, 4-Thiadiazol-2-amine (9CI)|1,3, 4-Thiadiazole, 2-Amino- (8CI)|1,3, 4-Thiadiazole, 2-amino- (8CI)|1,3,4-Thiadiazole, 2-Amino|1,3,4-Thiadiazole, 2-amino|2-Amino 134-Thiadiazole|2-Amino-1,3,4-thiadiazole|2-Amino-1-thia-3,4-diazole|2-Aminothiadiazole|ATDA|Amino 134-Thiadiazole|FDA 0084|NSC 4728	A synthetic derivative of nicotinamide adenine dinucleotide (NAD). Aminothiadiazole competitively inhibits inosine 5-monophosphate dehydrogenase, thereby disrupting the regulation of cell proliferation and differentiation in a number of cells.  This agent is also a selective human adenosine A3 receptor antagonist. (NCI04)
C1336	Cladribine	Purine_Antagonist|Radiosensitizing_Agent	Cladribine|2-CdA|2-Chloro-2-Deoxyadenosine|2-Chlorodeoxyadenosine|2CDA|CLADRIBINE|CdA|Cladribina|Leustat|Leustatin|Leustatine|RWJ-26251|cladribine	A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis.  Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04)
C1337	Cevimeline	Miscellaneous_Chemoprotective_Agent	Cevimeline Hydrochloride|AF-102B|CEVIMELINE HYDROCHLORIDE|Cevimeline|Evoxac|cevimeline	A cholinergic analogue which binds to muscarinic receptors, thereby increasing exocrine gland secretions (i.e. saliva and tears) and tone of smooth muscle in the gastrointestinal and urinary tracts. (NCI)
C1338	Didox	Anti-HIV_Agent|Ribonucleotide_Reductase_Inhibitor	Didox|3,4-Dihydroxybenzohydroxamic Acid|3,4-Dihydroxybenzohydroxamic acid	3,4-dihydroxybenzohydroxamic acid.  An inhibitor of ribonucleotide reductase.
C1339	BW_A773U	Intercalating_Agent	BW A773U|1,3-Propanediol, 2-((3-fluoranthenylmethyl)amino)-2-methyl-|773U82|BW 773U82	A three substituted fluoranthene derivative of the 2-(arylmethylamino)-1,3-propanediol family that intercalates with DNA, causing inhibition of DNA synthesis. (NCI)
C1340	Valrubicin	Anthracycline_Antibiotic	Valrubicin|AD 32|AD-32|N-Trifluoroacetyladriamycin-14-valerate|VALRUBICIN|Valstar|Valtaxin	A semisynthetic analogue of the anthracycline antineoplastic antibiotic doxorubicin.  Valrubicin exhibits antineoplastic properties through a variety of mechanisms.  Similar to related anthracyclines antibiotics, valrubicin interacts with topoisomerase II, leading to inhibition of DNA replication and repair and RNA and protein synthesis.  In addition, valrubicin accumulates in the cell cytoplasm where it inhibits protein kinase C (PKC).  Valrubicin is less cardiotoxic than doxorubicin when administered systemically; applied topically, this agent shows excellent tissue penetration. (NCI04)
C1341	Tyrphostin_A51	Tyrphostin_Compound	Tyrphostin A51|AG 183	A kind of Protein tyrosine kinase inhibitor involved in cell proliferation and differentiation. (NCI)
C1342	Ametantrone	Anthraquinone_Compound|Quinone_Compound	Ametantrone|1,4-bis[[2-[(2-Hydroxyethyl)amino]ethyl]amino]9,10-anthracenedione|9, 10-Anthracenedione, 1, 4-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-	A topoisomerase II inhibitor of the anthrapyrazole family that causes covalent cross-links in DNA of tumor cells. (NCI)
C1343	Aminosyn	Neuroprotective_Agent	Aminosyn|Aminosyn RF	An amino acid mixture for nutritional support
C1344	Pivaloyloxymethylbutyrate	Differentiation_Inducer	Pivaloyloxymethylbutyrate|AN-9|Pivanex	An acyloxyalkyl ester prodrug of butyric acid. Pivaloyloxymethylbutyrate inhibits histone deacetylase, resulting in cell differentiation, cell growth inhibition, and apoptosis. (NCI04)
C1345	Pamidronate_Disodium	Biphosphonate	Pamidronate Disodium|Aminomux|Aredia|GCP-23339A|PAMIDRONATE DISODIUM|Pamidronate|pamidronate	A drug that belongs to the family of drugs called bisphosphonates. Pamidronate is used as treatment for abnormally high levels of calcium in the blood.
C1346	Asaley	Miscellaneous_Alkylating_Agent	Asaley|ASALEY|Asalex|Ethyl ester of N-acetyl-DL-sarcolysyl-L-leucine|L-Leucine, N-[N-acetyl-4-[bis(2-chloroethyl)amino]-DL-phenylalanyl]-, ethyl ester (9CI)|L-Leucine, N-[N-acetyl-4-[bis-(2-chloroethyl)amino]-DL-phenylalanyl]-, ethylester|L-leucine, N-[N-acetyl-4-[bis(2-chloroethyl)amino]-DL-phenylalanyl]-, ethyl ester (9CI)|L-leucine, N-[N-acetyl-4-[bis-(2-chloroethyl)amino]-DL-phenylalanyl]-, ethylester|Leucine, N-[N-acetyl-3-[p-[bis(2-chloroethyl)amino]phenyl]-DL-alanyl]-, ethyl ester, L- (8CI)|ethyl ester of N-acetyl-DL-sarcolysyl-L-leucine|leucine, N-[N-acetyl-3-[p-[bis(2-chloroethyl)amino]phenyl]-DL-alanyl]-, ethyl ester, L- (8CI)	An L-leucine derivative of melphalan with antineoplastic activity. Asaley alkylates and crosslinks DNA, resulting in disruption of DNA synthesis. (NCI04)
C1347	Azimexon	Cytoprotective_Agent|Immunostimulant|Radioprotective_Agent	Azimexon|2-Aziridinecarboxamide, 1-[1-(2-cyano-1-aziridinyl)-1-methylethyl]|AZ|Azimexone|BM 12.531|BM12531	Azimexon (2-cyanaziridinyl-2-carbamoyl-aziridinyl-1-propane) is a derivative of 2-cyanaziridine. Immunostimulant which shows therapeutic effects in tumor models and experimental infections in vitro, enhancing T lymphocyte transformation and phagocytosis. The mode of action of azimexon is unknown. It has been suggested that azimexon may alkylate DNA. In cancer patients it increases leukocytosis, blood active T rosettes, T4/T8 ratio, and is used as an adjuvant to chemotherapy in the treatment of melanoma and myeloma. (NCI)
C1348	Bestrabucil	Immunosuppressant|Nitrogen_Mustard_Compound	Bestrabucil|Atrimustine|KM2210	The benzoate of a estradiol-chlorambucil conjugate. (NCI)
C1349	Recombinant_Inhibin_B	Recombinant_Inhibins	Recombinant Inhibin B|Inhibin Beta	A recombinant therapeutic agent which is chemically identical to or similar to an endogenous glycoprotein which inhibits pituitary production of follicle-stimulating hormone (FSH).  Produced and secreted by the testis or ovarian follicle, endogenous inhibin B contributes to the control of gametogenesis, embryonic and fetal development, and hematopoiesis. (NCI04)
C1350	Beta-Thioguanine_Deoxyriboside	Purine_Antagonist	Beta-Thioguanine Deoxyriboside|.beta.-2'-Deoxy-6-thioguanosine|.beta.-2'-Deoxythioguanosine|.beta.-2'-Deoxythiol guanosine|.beta.-Thioguanine deoxyriboside|1,9-dihydro-6H-purine-6-thione, 2-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)|2'-Deoxythioguanosine|2'-Desoxy-6-thioguanosine|2'-deoxythioguanosine|2'-desoxy-6-thioguanosine|6-Mercaptoguaninedeoxyriboside|6H-Purine-6-thione, 2-amino-9-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-1,9-dihydro-|9H-Purine-6-thiol, 2-amino-9-(2-deoxy-.beta.-D-erythro-pentofuranosyl)-, monohydrate|9H-purine-6-thiol, 2-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl) monohydrate|B-TGDR|BTG|Beta Thioguanine Deoxyriboside|Deoxythioguanosine|NSC 71261|Thioguanine 9.beta.D-2'-deoxyriboside|beta-2'-deoxy-6-thioguanosine|beta-2'-deoxythioguanosine|beta-2'-deoxythiol guanosine|thioguanine 9-.beta-D-2'-deoxyriboside	A thiopurine nucleoside derivative with antineoplastic activity. After conversion to the triphosphate, beta-thioguanine deoxyriboside is incorporated into DNA, resulting in inhibition of DNA replication.  This agent is cytotoxic against leukemia cell lines and has demonstrated some activity against leukemia cells in vivo.  Beta-thioguanine deoxyriboside demonstrates antineoplastic activity against 6-thioguanine-resistant tumor cells. (NCI04)
C1351	Bismuth_Subcitrate	Anti-ulcer_Agent|Cytoprotective_Agent	Bismuth Subcitrate	A mineral compound that is used to treat duodenal and gastric ulcers associated with Helicobacter pylori. (NCI)
C1352	Therapeutic_Brain-Derived_Growth_Factors	Therapeutic_Neurotrophic_Factor	Recombinant Brain-Derived Growth Factors|BDNF|Brain-Derived Neurotrophic Factor	Recombinant therapeutic agents chemically identical to or similar to endogenous nerve growth factors (neurotrophins) that play vital roles in the development of the nervous system.  Brain-derived growth factors may also regulate hematopoiesis and immune cell function.  Examples of brain-derived growth factors include nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). (NCI04)
C1353	Granisetron	Antiemetic_Agent	Granisetron Hydrochloride|GRANISETRON HYDROCHLORIDE|Granisetron|Kytril|granisetron	A drug that prevents or reduces nausea and vomiting.  It belongs to the family of drugs called antiemetics.
C1354	Crisnatol_Mesylate	Intercalating_Agent	Crisnatol Mesylate|BW A770U|BW A770U Mesylate|Crisnatol|crisnatol mesylate	An anticancer drug that interferes with the DNA in cancer cells.
C1355	Calcium_Citrate	Nutritional_Supplement	Calcium Citrate|2-Hydroxy-1,2,3-propanetricarboxylic Acid, Calcium Salt (2:3)|Acicontral|Citracal|Tricalcium Citrate	The citrate salt of calcium. An element necessary for normal nerve, muscle, and cardiac function, calcium as the citrate salt helps to maintain calcium balance and prevent bone loss when taken orally. This agent may also be chemopreventive for colon and other cancers. (NCI04)
C1356	Carbetimer	Immunostimulant	Carbetimer|N-137|NED-137|carbethimer|carboxyaminidate	Carbetimer (carboxyimamidate) is a low molecular weight derivatized copolymer of ethylene and maleic anhydride.  It has demonstrated antitumor activity against several animal models.  It has calcium chelation activity but seems to inhibit growth of sensitive cells by disrupting nucleoside uptake and metabolism.
C1357	Mivobulin_Isethionate	Tubulin_Binding_Agent	Mivobulin Isethionate|CI-980|CI-980 (Mivobulin Isethionate)|CI980|mivobulin isethionate	A synthetic colchicine analogue with potential antineoplastic activity.  Mivobulin isethionate binds to tubulin, thereby inhibiting microtubule polymerization and mitosis. (NCI04)
C1358	Therapeutic_CTAP_III	Therapeutic_Alpha_Chemokine	Recombinant CTAP III|CTAP III	Connective Tissue-Activating Peptide III is a platelet-derived growth factor that stimulates in fibroblasts mitogenesis, extracellular matrix synthesis, glucose metabolism, and plasminogen activator synthesis through interaction with a GPCR.  It is present in platelet granules, released by inducers of platelet aggregation, and is chemoattractant for fibroblasts, presumably for repair.  Pro-platelet basic protein is the precursor of platelet basic protein (PBP) and CTAP III.  Upon platelet activation they are released and processed in plasma to beta-thromboglobulin and neutrophil-activating peptide-2.  The thrombocidins TC1 and TC2 are variants of NAP2 and CTAP III, respectively.  TC1 and TC2 differ from NAP2 and CTAP III by their bactericidal and fungicidal properties, which apparently do not involve pore formation.  (from OMIM 121010 and NCI)
C1359	Cyclopentenyl_Cytosine	Cytidine_Triphosphate_Synthetase_Inhibitor|Pyrimidine_Antagonist	Cyclopentenyl Cytosine|2(1H)-Pyrimidinone, 4-amino-1-[4, 5-dihydroxy- 3-(hydroxymethyl)-2-cyclopenten-1-yl]-|CPE-C|Cyclopentenylcytosine|Cyclopentenylcytosine Triphosphate	A synthetic cyclopentenyl antimetabolite analogue of cytidine with antineoplastic activity and antiviral activity.  Cyclopentenyl cytosine competitively inhibits cytidine triphosphate (CTP) synthetase, thereby depleting cytidine pools and inhibiting DNA synthesis.  This agent may also induce differentiation of some tumor cell types. Cyclopentenyl cytosine's antiviral activity is broad-spectrum. (NCI04)
C1360	Cytembena	Miscellaneous_Antimetabolite	Cytembena|2-Butenoic Acid, 3-Bromo-4-(4-methoxyphenyl)-4-oxo-, Sodium Salt, (Z)- (9CI)|2-Butenoic acid, 3-bromo-4-(4-methoxyphenyl)-4-oxo-, sodium salt, (Z)- (9CI)|Acrylic Acid, 3-p-Anisoyl-3-bromo-, Sodium Salt|Acrylic acid, 3-p-anisoyl-3-bromo-, sodium salt|CTB|Cytembena Spofa|Sodium Bromebrate|Sodium Bromebrate/Cytembena|Sodium cis-Beta-4-methoxybenzoyl-beta-bromacrylate|WR-149912	A cytostatic agent that interferes with DNA synthesis.
C1361	Depudecin	Histone_Deacetylase_Inhibitor	Depudecin|(2R,3S,4S,5E,7S,8S,9R)-2,9- Dihydroxy-3,4;7,8-diepoxy-undeca-5,10-diene|(2S-(2R*(E(2R*(S*),3R*)),3R*(S*)))-alpha-Ethenyl-3-(2-(3-(1-hydroxyethyl)oxiranyl)ethenyl)oxiranemethanol|Oxiranemethanol, Alpha-ethenyl-3-(2-(3-(1-hydroxyethyl) oxiranyl)ethenyl)-, (2S- (2R*(E(2R*(S*),3R*)),3R*(S*)))-	Depudecin is a fungal metabolite that reverts the rounded phenotype of NIH 3T3 fibroblasts transformed with v-ras and v-src oncogenes to the flattened phenotype of the non-transformed parental cells. The mechanism of de-transformation induced by this agent had not been determined. However, depudecin has been demonstrated to inhibit histone deacetylase (HDAC) activity effectively both in vivo and in vitro.
C1362	Dexamethasone_Sodium_Phosphate	Dexamethasone	Dexamethasone Sodium Phosphate|Cebedex|DEXAMETHASONE SODIUM PHOSPHATE|Dalalone|Decaject|Dekasol LA|Dexacen|Dexasone|Dezone|Soludecadron|Solurex	A sodium phosphate salt form of Dexamethasone, a synthetic adrenal corticosteroid with potent anti-inflammatory properties. In addition to binding to specific nuclear steroid receptors, dexamethasone also interferes with NF-kB activation and apoptotic pathways. This agent lacks the salt-retaining properties of other related adrenal hormones. (NCI04)
C1363	Diaziquone	Ethylenimine_Compound	Diaziquone|1,4-Cyclohexadiene-1,4-dicarbamic acid, 2, 5-bis(1-aziridinyl)-3,6-dioxo-, diethyl ester|1,4-cyclohexadiene-1,4-dicarbamic acid, 2, 5-bis(1-aziridinyl)-3,6-dioxo-, diethyl ester|1,4-cyclohexadiene-1,4-dicarbamic acid,2,5-bis(1-aziridinyl)-3,6-dioxo,-diethyl ester|2,5-bis(1-aciridinyl)-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone|2,5-bis(1-aziridinyl)-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone|2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-dicarbamic acid diethyl ester|2,5-diaziridinyl-3,6-bis(ethoxycarbonyl-amino)-1,4-benzoquinone|AZQ|Aziridinyl Benzoquinone|Aziridinylbenzoquinone|Aziridinylbenzoquinone carbamic acid|CI-904|Carbamic acid, [2,5-bis(1-aziridinyl)-3,6-dioxo-1, 4-cyclohexadiene-1,4-diyl]bis-, diethyl ester (9CI)|NSC 182986|[2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-diyl]biscarbamic acid diethyl ester|carbamic acid, [2,5-bis(1-aziridinyl)-3,6-dioxo-1, 4-cyclohexadiene-1,4-diyl]bis-, diethyl ester (9CI)|diaziquone	A synthetic bifunctional quinone derivative with potential antineoplastic activity. Diaziquone alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.  This agent can also form free radicals, thereby initiating DNA damage via DNA strand breaks.  Due to its lipophilicity, diaziquone readily crosses the blood brain barrier. (NCI04)
C1364	Didemnin_B	Depsipeptide_Antibiotic|Immunosuppressant|Protein_Synthesis_Inhibitor	Didemnin B|1-Oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]- L-prolyl]-N,O-dimethyl-, .phi.-lactone (9CI)|15H-Pyrrolol[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotri-cosine, Cyclic Peptide Deriv. (9CI)|Didemnin|L-Tyrosine, N-[1-[N-[4-[[3-Hydroxy-4-[[N-[N-[1-(2-hydroxy-1-oxopropyl)- L-prolyl]-N-methyl-L-leucyl]-L-threonyl]amino-5-methyl-1-oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]- L-prolyl]-N,O-dimethyl-, .phi.-lactone (9CI)|L-Tyrosine, N-[1-[N-[4-[[3-hydroxy-4-[[N-[N-[1-(2-hydroxy-1-oxopropyl)- L-prolyl]-N-methyl-L-leucyl]-L-threonyl]amino-5-methyl- 1-oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]- L-prolyl]-N,O-dimethyl-, .phi.-lactone (9CI)	A cyclic depsipeptide extracted from the Caribbean tunicate Trididemnum cyanophorum.  Didemnin B activates caspase, thereby inducing apoptosis, and prevents eukaryotic elongation factor 2 (eEF-2)-dependent translocation, thereby inhibiting protein synthesis.  This agent also has immunosuppressive and antiviral properties. (NCI04)
C1365	Dimesna	Uroprotective_Agent	Dimesna|2,2'-Dithio-bis-ethanesulfonate, Disodium Salt|2,2'-Dithiobisethanesulfonic Acid, Disodium Salt|BNP7787|Mesna Disulfide|Tavocept|dimesna	A drug that belongs to the family of drugs called chemoprotective agents.
C1366	Doxorubicin-HPMA_Conjugate	Doxorubicin	Doxorubicin-HPMA Conjugate|Doxorubicin-HPMA|Doxorubicin-HPMA Copolymer Conjugate|HPMA-Doxorubicin|P(GFLG)-ADR|PK1	A copolymer conjugate of the anthracycline antineoplastic antibiotic doxorubicin and the water-soluble polymer N-(2-hydroxypropyl) methacrylamide (HPMA).  Conjugation with HPMA improves the therapeutic effects of doxorubicin, by promoting drug accumulation inside tumors, while decreasing systemic toxicity.  Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. (NCI04)
C1367	Elliptinium	Intercalating_Agent|Topoisomerase-II_Inhibitor	Elliptinium|6H-Pyrido[4, 3-b]carbazolium, 9-hydroxy-2,5,11-trimethyl-acetate (salt)|9-Hydroxy-2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium Acetate (Salt)|9-Hydroxy-2-methylellipticinium Acetate|9-Hydroxy-2-methylellipticinium acetate|Celiptium|Elliptinium Acetate|HME	A derivative of the alkaloid ellipticine isolated from species of the plant family Apocynaceae, including Bleekeria vitensis, a plant with anti-cancer properties.  As a topoisomerase II inhibitor and intercalating agent, elliptinium stabilizes the cleavable complex of topoisomerase II and induces DNA breakages, thereby inhibiting DNA replication and RNA and protein synthesis (NCI04)
C1368	Therapeutic_ENA-78	Therapeutic_Alpha_Chemokine	Recombinant ENA-78|ENA-78|LIX|Lipopolysaccharide-Induced CXC Chemokine	Epithelial neutrophil activating peptide-78.  A 78 amino acid member of the CXC family of chemokines, produced and secreted upon stimulation by interleukin 1 beta or tumor necrosis factor alpha.  Stimulates chemotactic migration of neutrophils, monocytes, lymphocytes, and fibroblasts.
C1369	Recombinant_Fibroblast_Growth_Factor_6	Therapeutic_Fibroblast_Growth_Factor	Recombinant Fibroblast Growth Factor 6|FGF-6|FGF6|HBGF-6|HST-2	A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 6 (FGF-6).  Because of the mitogenic effects of FGF-6 on fibroblasts and endothelial cells and the stimulatory effects of FGF-6 on muscle stem cell migration, therapeutic FGF-6 has a potential role in wound healing and muscle regeneration. (NCI04)
C1370	Recombinant_Fibroblast_Growth_Factor_5	Therapeutic_Fibroblast_Growth_Factor	Recombinant Fibroblast Growth Factor 5|FGF5|HBGF-5	A recombinant form of the heparin-binding fibroblast growth factor 5 (FGF-5).  FGF-5 may function as a growth factor during embryogenesis and may have a role in wound repair throughout adulthood because of its mitogenic effects on fibroblasts and endothelial cells.  Overexpressed in certain tumor cell types, this agent may promote tumor growth and angiogenesis. (NCI04)
C1371	Fosquidone	Unclassified_Chemotherapy_Agent	Fosquidone|GR 63178A
C1372	Fostriecin	Protein_Phosphatase_Inhibitor|Topoisomerase-II_Inhibitor	Fostriecin|2H-pyran-2-one,5,6-dihydro-6-(3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11,-tridecatetraenyl)-,trans|Phosphotrienin	An anti-tumor antibiotic isolated from the bacterium Streptomyces pulveraceus. Fostriecin inhibits topoisomerase II catalytic activity, resulting in protein-associated strand breaks and impaired DNA and RNA synthesis in various malignant cell types.  This agent also inhibits serine/threonine protein phosphatase type 2A in some tumor cell types, thereby interfering with cellular proliferation and differentiation. (NCI04)
C1373	Girodazole	Protein_Synthesis_Inhibitor	Girodazole|3-Amino-1-[4-(2 amino-1H-imidazolyl]-propanol, 2HCl|Giroline|RP 49532A	A compound isolated from the marine sponge Pseudaxinyssa cantharella exhibiting anti-tumor activity.  Studies indicate girodazole acts during the elongation/termination steps of protein synthesis, resulting in protein synthesis inhibition. (NCI)
C1374	Goserelin	Gonadotropin-Releasing_Hormone_Analog	Goserelin|6-[O-(1,1-Dimethylethyl)-D-serine]-10-deglycinamide Luteinizing Hormone-Releasing Factor (Pig) 2-(aminocarbonyl)hydrazide|ICI-118630|goserelin	A drug that belongs to the family of drugs called gonadotropin-releasing hormone analogues. Goserelin is used to block hormone production in the ovaries or testicles.
C1375	Guanidinium	Nitrogen_Compound	Guanidinium
C1376	Halichondrin_B	Tubulin_Binding_Agent	Halichondrin B	A complex macrolide polyether from marine sponge genera, such as Halichondria, Axinella, Phakellia, and Lissodendoryx that binds to tubulin, thereby inhibiting mitosis. (NCI)
C1377	Hematoporphyrin_Derivative	Photosensitizing_Agent|Porphyrin	Hematoporphyrin Derivative|hematoporphyrin derivative	A drug used in photodynamic therapy that is absorbed by tumor cells. When exposed to light, it becomes active and kills the cancer cells.
C1378	Antimoniotungstate	Reverse_Transcriptase_Inhibitor	Antimoniotungstate|21-Tungsto-9-antimonate|5-Tungsto-2-antimonate|Ammonium 5-Tungsto-2-antimonate|HPA-23|Hexaoctacontaoxononaantimonateheneicosatungstate(19-) Heptadecaammonium Disodium	An anti-HIV agent.  May also function as an antineoplastic agent
C1379	Fulvestrant	Selective_Estrogen_Receptor_Down_Regulator	Fulvestrant|"Faslodex (Fulvestrant, ICI182780)"|7a-[9-[(4,4,5,5,5,-Pentafluoropentyl)sulphinyl]nonyl]-estra-1,3,5(10)-triene-3,17b-diol|Faslodex|Faslodex(ICI 182,780)|Fulvestrant (Faslodex)|ICI 182,780|ICI 182780|ZD9238	A drug that blocks estrogen activity in the body and is used in the therapy of estrogen-dependent tumors such as breast cancer.
C1380	Therapeutic_Interleukin-12	Miscellaneous_Angiogenesis_Inhibitor|Therapeutic_Interleukin	Recombinant Interleukin-12|Cytotoxic Lymphocyte Maturation Factor|IL-12|Interleukin 12|Interleukin-12|Natural Killer Cell Stimulatory Factor|Recombinant human interleukin-12 (IL-12) cytokine|Ro 24-7472|interleukin-12	(in-ter-LOO-kin) IL-12. A type of biological response modifier (a substance that can improve the body's natural response to infection and disease) that enhances the ability of the immune system to kill tumor cells and may interfere with blood flow to the tumor. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases.
C1381	Irinotecan	Camptothecin_Analogue	Irinotecan Hydrochloride|(+)-(4S)-4,11-diethyl-4-hydroxy-9-[(4-piperidino-piperidino)carbonyloxy]-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinol-3,14,(4H,12H)-dione|(+)-7-ethyl-10-hydroxycamptothecine 10-[1,4'-bipiperidine]-1'-carboxylate|7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin|CPT 11|CPT-11|Campto|Camptosar|Camptothecin 11|Camptothecin-11|IRINOTECAN HYDROCHLORIDE|Irinotecan|Irinotecan (CPT-11, Camptosar)|Irinotecan HCl|U-101440E|[1,4'-bipiperidine]-1'-carboxylic acid (S)-4,11-diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl ester|irinotecan	A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.  Irinotecan, a prodrug, is converted to a biologically active metabolite 7-ethyl-10-hydroxy-camptothecin (SN-38) by a carboxylesterase-converting enzyme.  One thousand-fold more potent than its parent compound irinotecan, SN-38 inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death.  Because ongoing DNA synthesis is necessary for irinotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent. (NCI04)
C1382	K_252a	Protein_Kinase_C_Inhibitor	K 252a|K-252a	A fungal alkaloid from Nocardiopsis species, which inhibits protein kinase C. (NCI)
C1383	Liposomal-Cisplatin_Analogue	Platinum_Compound	Liposomal-Cisplatin Analogue|Aroplatin|Liposomal-Entrapped Cis-Bis-Neodecanoate-trans-R,R-1,2-Diaminocyclohexane Platinum (II)	Platar is a liposomal formulation of a novel platinum drug designed to overcome the toxicity and drug resistance that currently limit the usefulness of platinum
C1384	Therapeutic_Leukemia_Inhibitory_Factor	Therapeutic_Cytokine	Recombinant Leukemia Inhibitory Factor|LIF	affects many systems, including hematopoietic, embryonic, bone, hepatic, neuronal, and fat tissues.
C1385	Levonantradol	Antiemetic_Agent	Levonantradol|Levonantradol HCl	A synthetic cannabinoid analogue of delta (9)-tetrahydrocannabinol (delta(9)-THC) with antiemetic and anti-analgesic properties. Although its precise mechanism of action is unknown, levonantradol appears to bind and activate the cannabinoid receptors CB1 and/or CB2. (NCI04)
C1386	Isosulfan_Blue	Dye	Isosulfan Blue|ISOSULFAN BLUE|Lymphazurin|N-[4-[4-(Diethylamino)phenyl] (2,5-disulfophenyl) Methylene]-2,5-cyclohexadien-1-ylidene]-N-ethylethanaminium Hydroxide	A synthetic visual lymphatic imaging agent.  Injected into the periphery of the tumor site, isosulfan blue localizes to the lymphatic system and aids in the surgical identification of tumor sentinel nodes which stain blue. (NCI04)
C1387	MAGE-1_Antigen	Tumor_Antigen	MAGE-1 Antigen	A cancer specific antigen expressed by the melanoma antigen gene.
C1388	Maxzide	Diuretic	Maxzide	A combination drug containing hydrochlorothiazide and triamterene used as a diuretic.
C1389	Menogaril	Anthracycline_Antibiotic	Menogaril|7(R)-O-Methylnogarol|7-(R)-O-methylnogarol|7-OMEN|7-con-O-Methylnogarol|7-con-O-methylnogarol|7-con-O-methylnorgarol|MENOGARIL|Menogarol|NSC 269148|OMEN,7-|TUT-7|U-52047|[2R-(2alpha,3beta,4alpha,5beta,6alpha,11alpha,13alpha)]-4-(dimethylamino)-3,4,5,6,11,12,13,14-octahydro-3,5,8,10,13-pentahydroxy-11-methoxy-6,13-dimethyl-2,6-epoxy-2H-naphthaceno[1,2-b]oxocin-9,16-dione	A semisynthetic derivative of the anthracycline antineoplastic antibiotic nogalamycin.  Menogaril intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent is less cardiotoxic than doxorubicin. (NCI04)
C1390	Merbarone	Topoisomerase-II_Inhibitor	Merbarone	An inhibitor of Topoisomerse II, interfering with DNA replication.
C1391	Therapeutic_Macrophage_Inflammatory_Protein-1_Alpha	Therapeutic_Beta_Chemokine	Recombinant Macrophage Inflammatory Protein-1 Alpha|CCL3|LD78|LD78 alpha (e)|MIP-1 Alpha|MIP-1a	A recombinant therapeutic agent which is chemically identical to or similar to endogenous macrophage inflammatory protein-1, a member of the CC chemokine family produced by activated macrophages.  Macrophage inflammatory protein-1 alpha activates granulocytes and induces pro-inflammatory cytokine synthesis.  The addition of macrophage inflammatory protein-1 alpha to a vaccine consisting of a DNA immunogen or a pro-inflammatory peptide may enhance vaccine-induced host immune anti-tumor responses. (NCI04)
C1392	Mitomycin_B	Mitomycin_Antibiotic	Mitomycin B|Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 1,1a,2,8,8a,8b-hexahydro-8a-hydroxy-8-(hydroxymethyl)-6-methoxy-1,5-dimethyl-, 8-carbamate	A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus.  Bioreduced mitomycin B generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis. (NCI04)
C1393	Therapeutic_Monocyte_Chemoattractant_Protein_1	Therapeutic_Beta_Chemokine	Recombinant Monocyte Chemoattractant Protein-1|CCL2|HC11|Human Macrophage Chemoattractant Protein-1|MCAF|MCP-1|Monocyte Chemoattractant Protein 1|Monocyte Chemotactic Protein-1|Monocyte Chemotactic and Activating Factor	A recombinant therapeutic agent which is chemically identical to or similar to endogenous human monocyte chemoattractant protein-1, a member of the CC chemokine family which is chemotactic for monocytes. (NCI04)
C1394	Muramyl_Tripeptide_Phosphatidylethanolamine	Immunostimulant	Muramyl Tripeptide Phosphatidylethanolamine|CGP19835A|MTP-PE(CGP19835A)	A synthetic analogue of muramyl dipeptide (MDP), a component of bacterial cell walls. Muramyl tripeptide phosphatidylethanolamine activates monocytes and macrophages, resulting in the induction of multiple cytokines (Il-1 alpha and beta, Il-7, IL-8, IL-12, and TNF) and potential tumoricidal activity. (NCI04)
C1395	Vinorelbine_Ditartrate	Vinorelbine	Vinorelbine Ditartrate|Biovelbin|Eunades|NVB|Navelbine|Navelbine Ditartrate|Navelbine ditartrate|VINORELBINE TARTRATE|Vinorelbine Tartrate	The ditartrate salt of a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic properties.  Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity, whereas inhibition of axonal microtubules seems to correlate with vinorelbine's neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account for its decreased neurotoxicity.  This agent is also a radiation-sensitizing agent. (NCI04)
C1396	Therapeutic_Neurotrophins	Retired_Concepts	Recombinant Neurotrophins|Neurotrophic Factor	family of polypeptide growth factors produced by peripheral target tissues as well as the nervous system, which are critical to neuronal growth, regeneration, survival, and differentiation.
C1397	Human_Papillomavirus_Type_16_Protein_E6	Papillomavirus_Transforming_Protein-E6	Human Papillomavirus Type 16 E6 Protein|HPV 16 E6 Peptide|HPV-16 E6|HPV-16 E6 Peptide|HPV16 E6|Human Papillomavirus 16 E6 Peptide
C1398	N-Phosphonacetyl-L-aspartate	Multidrug_Resistance_Modulator|Pyrimidine_Antagonist	N-Phosphonacetyl-L-aspartate|L-Aspartic Acid, N-(Phosphonoacetyl)-, Tetrasodium Salt (9CI)|L-Aspartic Acid, N-(Phosphonoacetyl)-tetrasodium Salt|N-Phosphonacetyl-1-aspartate|PALA|Sparfosate|Sparfosate Tetrasodium	A pyrimidine antimetabolite with antineoplastic activity.  N-phosphonacetyl-L-aspartate inhibits pyrimidine biosynthesis and increases the extent to which fluorouracil is incorporated into RNA. (NCI04)
C1399	Peplomycin	Bleomycin_Antibiotic	Peplomycin|(S)-n1-[3-[(1-phenylethyl)amino]propyl]bleomycinamide|PEP|PEPLEOMYCIN|Pepleomycin|n1-[3[[(S)-alpha-methylbenzyl]amino]propyl]bleomycinamide	A semisynthetic analog of Bleomycin, a mixture of several basic glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus.  Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA.  This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI04)
C1400	Peplomycin_Sulfate	Peplomycin	Peplomycin Sulfate|NK-631	The sulfate salt of the bleomycin analogue peplomycin.  Peplomycin forms complexes with iron that reduce molecular oxygen to superoxide and hydroxyl radicals that cause single- and double-stranded breaks in DNA.  This agent appears to show greater antitumor activity than bleomycin; its use is limited due to pulmonary toxicity. (NCI04)
C1401	Piperazinedione	Miscellaneous_Alkylating_Agent	Piperazinedione|2, 5-Piperazinedione, 3,6-bis-(5-chloro-2-piperidyl)-, dihydrochloride|2, 5-piperazinedione, 3,6-bis-(5-chloro-2-piperidyl)-, dihydrochloride|2,5-Piperazinedione, 3, 6-bis(5-chloro-2-piperidinyl)-, dihydrochloride, [3S-[3.alpha.(2S*,5R*),6.alpha.(2S*,5R*)]]- (9CI)|2,5-piperazinedione, 3, 6-bis(5-chloro-2-piperidinyl)-, dihydrochloride, [3S-[3.alpha.(2S*,5R*),6.alpha.(2S*,5R*)]]- (9CI)|593A|Compound 593A|Crystalline Antibiotic|Merck Compound 593A;|PZD dihydrochloride, 3,6-bis(5-chloro-2-piperidinyl)-, dihydrochloride|Piperazinedione Actinomycete Fermentation Product	An alkylating agent with antineoplastic activity. Piperazinedione selectively inhibits DNA synthesis, arresting tumor cells in the G2 phase of the cell cycle. (NCI04)
C1402	Prednisolone_Sodium_Phosphate	Prednisolone	Prednisolone Sodium Phosphate|Ak-Pred|Inflamase|Key-Pred SP|PREDNISOLONE SODIUM PHOSPHATE|Pediapred|Polypred|Predmix|Prednabene|Prednesol|Prednisol|Predsol	The sodium phosphate salt form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.  After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production.  This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI)
C1403	Prednisolone_Sodium_Succinate	Prednisolone	Prednisolone Sodium Succinate|Precortalon Aquosum|Prednisolone sodium succinate	The sodium succinate salt form of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.  After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production.  This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI)
C1404	Protein_Kinase_Inhibitor	Enzyme_Inhibitor	Protein Kinase Inhibitor	Substances that inhibit the protein phosphorylation in the signaling pathway, which regulates a variety of fundamental processes, such as cell growth, mitogenesis, metabolism, gene transcription, cell cycle control, and the immune response. (NCI)
C1405	Valspodar	Multidrug_Resistance_Modulator	Valspodar|6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic Acid]cyclosporin D|Amdray|Cyclo((2S,4R,6E)-4-methyl-2-(methylamino)-3-oxo-6-octenoyl)-L-valyl-N-methylglycyl-N-methyl-L-leucyl-L-valyl-N-methyl-L-leucyl-L-alanyl-D-alanyl-N-me|PSC 833|PSC-833	A drug that belongs to the family of drugs called cyclosporine analogues. It is used with chemotherapy to prevent or overcome the resistance of tumor cells to some anticancer drugs.
C1406	Idoxifene	Selective_Estrogen_Receptor_Modulator	Idoxifene|1-[2-[4-[(1E)-1-(4-Iodophenyl)-2-phenyl-1-butenyl]phenoxy]ethyl]pyrrolidine|Pyrrolidino-4-iodotamoxifen|SB-223030|idoxifene	A drug that blocks the effects of estrogen.
C1407	RG_13022	Tyrphostin_Compound	RG 13022|RG-13022|Tyrphostin RG-13022	A tyrosine kinase inhibitor that selectively inhibits epidermal growth factor receptor, epidermal factor-stimulated HER14 cell proliferation, and tumor growth in vivo. (NCI)
C1408	Rifabutin	Antitubercular_Agent	Rifabutin|Mycobutin|RIFABUTIN|Rifabutin/Microbutin	A semisynthetic ansamycin antibiotic with potent antimycobacterial properties.  Rifabutin inhibits bacterial DNA-dependent RNA polymerase, thereby suppressing the initiation of RNA formation and leading to inhibition of RNA synthesis and transcription. (NCI04)
C1409	Carbenicillin_Indanyl_Sodium	Carbenicillin	Carbenicillin Indanyl Sodium|Geocillin	The indanyl sodium salt form of the penicillin antibiotic carbenicillin.  Carbenicillin inhibits peptidoglycan synthesis involved in bacterial cell, hence inhibiting cell wall biosynthesis causing the bacteria to lyse. (NCI)
C1410	Therapeutic_Stem_Cell_Factor	Therapeutic_Colony_Stimulating_Factor	Recombinant Stem Cell Factor|Mast Cell Growth Factor|Steel Factor|c-Kit Ligand	A therapeutic hematopoietic glycoprotein cytokine.  Therapeutic recombinant human stem cell factor (rhSCF) binds to c-kit and stimulates the growth of peripheral blood progenitor cells (PBPCs) and may promote bone marrow recovery after myeloablative therapies and procedures. (NCI04)
C1411	Paclitaxel	Taxane_Compound	Paclitaxel|5Beta,20-epoxy-1,2alpha,4,7beta,10beta,13alpha-hexahydroxytax-11-en-9-one, 4,10-Diacetate 2-Benzoate 13-Ester with (2R,3S)-N-Benzoyl-3-phenylisoserine|Anzatax|Asotax|Bristaxol|PACLITAXEL|Paclitaxel (Taxol)|Praxel|Taxol|Taxol (Old NSC)|Taxol Konzentrat|[2aR-[2a Alpha,4beta,4a beta,6beta,9alpha(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-(benzoylamino)-alpha-hydroxybenzene-propanoic acid 6,12b-bis(acetyloxy)-12-(benzoyloxy)-1a,33,4,-41,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-41,8,-12,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester|paclitaxel	A compound extracted from the Pacific yew tree Taxus brevifolia with antineoplastic activity.  Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division.  This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). (NCI04)
C1412	Teicoplanin	Aminoglycoside_Antibiotic	Teicoplanin|Targocid|Teichomycin|teicoplanin	A glycopeptide antibiotic complex isolated from the bacterium Actinoplanes teichomyceticus. Teicoplanin inhibits peptidoglycan polymerization, resulting in inhibition of bacterial cell wall synthesis and cell death. (NCI04)
C1413	Topotecan	Camptothecin_Analogue	Topotecan|(s)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]-quinoline-3,14(4H,12H)-dione|9-[(dimethylamino)methyl]-10-hydroxy-(20S)-camptothecin|Hycamptamine|SKF S-104864-A|topotecan	A semisynthetic derivative of camptothecin, a cytotoxic, quinoline-based alkaloid extracted from the Asian tree Camptotheca acuminata.  Topotecan inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptotic cell death.  Because ongoing DNA synthesis is necessary for topotecan to exert its cytotoxic effects, it is classified as an S-phase-specific agent. (NCI04)
C1414	Trioxifene_Mesylate	Trioxifene	Trioxifene Mesylate|Ly-133314	A mesylate salt form of trioxifene, a nonsteroidal selective estrogen receptor modulator (SERM).  Trioxifene competitively inhibits the binding of estradiol to estrogen receptor alpha (ER alpha), resulting in ER alpha-mediated gene expression.  Clinical development of Trioxifene has not proceeded because of lack of superior results over tamoxifen and side effect profile. (NCI)
C1415	Vesnarinone	Differentiation_Inducer|Immunosuppressant	Vesnarinone|1-(3,4-Dimethoxybenzoyl)-4-(1,2,3,4-tetrahydro-2-oxo-6-quinolinyl)piperazine|3,4-Dihydro-6-(4-(3,4-dimethoxybenzoyl)-1-pip- erazinyl)- 2(1H)-quinolinone|Arkin|Arkin-Z|DRG-0210|Pieranometazine|Piperazine, 1-(3,4-dimethoxybenzoyl)-4-(1,2,3,4-tetrahydr- o -2-oxo-6-quinolinyl)	A cardiotonic quinolinone derivative, that suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an inhibitor of cyclin dependent kinase activity in p53-mediated cell cycle arrest. (NCI)
C1416	Yoshi-864	Alkylsulfonate_Compound	Yoshi-864|1-Propanol, 3,3'-, Dimethanesulfonate (Ester), Hydrochloride|1-Propanol, 3,3'-, dimethanesulfonate (ester), hydrochloride|1-Propanol, 3,3'-Iminobis-, Dimethanesulfonate (Ester), Hydrochloride (9CI|1-Propanol, 3,3'-iminobis-, dimethanesulfonate (ester), hydrochloride (9CI)|1-Propanol, 3,3'-iminodi-, Dimethanesulfonate (Ester), Hydrochloride (8CI)|1-Propanol, 3,3'-iminodi-, dimethanesulfonate (ester), hydrochloride (8CI)|1-Propanol-3,3'-iminodidimethanesulfonatehydrochloride|3, 3'-Dimesyloxydipropylamine HCl|3, 3'-Dimesyloxydipropylamine Hydrochloride|3, 3'-Dimesyloxydipropylamine hydrochloride|3, 3'-Iminodi-1-propanol Di(methanesulfonate) HCl|3, 3'-Iminodi-1-propanol Di(methanesulfonate) Hydrochloride|3, 3'-Iminodi-1-propanol Dimethanesulfonate Ester HCl|3, 3'-Iminodi-1-propanol Dimethanesulfonate Ester Hydrochloride|3, 3'-Iminodi-1-propanol di(methanesulfonate) hydrochloride|3, 3'-Iminodi-1-propanol dimethanesulfonate ester hydrochloride|3,3'-Imidodi-1-propanol, Dimethanesulfonate (Ester) HCl|3,3'-Imidodi-1-propanol, Dimethanesulfonate (Ester), Hydrochloride|3,3'-Imidodi-1-propanol, dimethanesulfonate (ester), hydrochloride|Bis(3-mesyloxypropyl)amine HCl|Bis(3-mesyloxypropyl)amine Hydrochloride|Bis(3-mesyloxypropyl)amine hydrochloride|Compound 864|IPD Hydrochloride|IPD hydrochloride|NCI-C01547|NSC 102627|Yoshi 864	An alkylsulfonate. Yoshi-864 alkylates and crosslinks DNA, thereby inhibiting DNA replication. (NCI04)
C1417	Goserelin_Acetate	Goserelin	Goserelin Acetate|D-Ser(bu(t))(6)azgly(10)-LHRH Acetate|Xoladex|ZDX|Zoladex	The acetate salt of a synthetic decapeptide analog of luteinizing hormone-releasing hormone (LHRH).  Continuous, prolonged administration of goserelin in males results in inhibition of pituitary gonadotropin secretion, leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI04)
C1418	Clodronate_Disodium	Biphosphonate	Clodronate Disodium|Bonefos|CL2MDP|Clasteon|Clodronate|Clodronic Acid Disodium Salt|Dichloromethylene Diphosphonate|Difosfonal|Loron|Mebonat|Ossiten|clodronate	A drug used as treatment for hypercalcemia (abnormally high levels of calcium in the blood) and for cancer that has spread to the bone (bone metastases). It may decrease pain, the risk of fractures, and the development of new bone metastases.
C1419	Tc_99m_Sestamibi	Radioconjugate	Tc 99m Sestamibi|Cardiolite|Miraluma|Tc-99m MIBI|Tc99m Sestamibi|Technetium Tc 99m Sestamibi	Sestamibi is a large synthetic molecule of the isonitrile family, which can be labeled with Tc99m.  It passes through cells membranes passively, collecting in cells with large numbers of mitochondria.  It is often used for imaging of the thyroid and parathyroid.
C1420	Photosensitizing_Agent	Pharmacologic_Substance	Photosensitizing Agent|Photosensitizer|Photosensitizers|photosensitizer	A drug used in photodynamic therapy. When absorbed by cancer cells and exposed to light, the drug becomes active and kills the cancer cells.
C1421	Oxygen_Radicals	Free_Radicals	Oxygen Radical|Oxygen Radicals	An oxygen species that carries an unpaired electron (e.g., the hydroxyl radical and the superoxide anion). These radicals are very powerful oxidizing agents and cause structural damage to proteins and nucleic acids. They mediate the damaging effects of ionizing radiation. (from Online Medical Dictionary)
C1422	Perflubron	Contrast_Agent|Radiosensitizing_Agent	Perflubron|Imagent|Imavist|Perfluorooctylbromide	A synthetic radiopaque liquid form of perfluorooctyl bromide.  Used as a contrast agent for magnetic resonance imaging (MRI), perflubron is also used as a liquid ventilation agent to improve pulmonary gas exchange and lung compliance and may be used in surgery to reduce or eliminate the need for donor blood.  Ventilation with perfluorocarbon fluid improves lung function in conditions involving surfactant deficiency and dysfunction, including respiratory distress syndrome and adult respiratory distress syndrome. (NCI04)
C1423	Perfosfamide	Nitrogen_Mustard_Compound	Perfosfamide|2-[bis(2-chloroethyl)amino]-4-hydroperoxytetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide|4'-Hydroperoxycyclophosphamide|4-HC|4-Hydroperoxycyclophosphamide|4-Pergamid|Hydroperoxycyclophosphamide|NSC 181815|Pergamid|cis-2-[bis(2-chloroethyl)amino]tetrahydro-3H-1,3,2-oxazaphosphorin-4-yl hydroperoxide P-oxide|cis-4-hydroperoxycyclophosphamide	The active metabolite of the nitrogen mustard cyclophosphamide with potent antineoplastic and immunosuppressive properties. Perfosfamide alkylates DNA, thereby inhibiting DNA replication and RNA and protein synthesis. (NCI04)
C1424	Sulforaphane	Chemopreventive_Agent	Sulforaphane|(+/-)-Sulforaphane|1-Isothiocyanato-4-(methylsulfinyl)butane|Sulfaforaphane|Sulforafan|Sulphoraphane	A naturally-occurring phytochemical belonging to the class of isothiocyanates.  As the aglycone metabolite of glucosinolate glucoraphanin (sulforaphane glucosinolate), sulforaphane acts as an antioxidant and potent stimulator of endogenous detoxifying enzymes.  This agent displays anticarcinogenic properties due to its ability to induce phase II detoxification enzymes, such as glutathione S-transferase and quinone reductase, thereby providing protection against certain carcinogens and toxic, reactive oxygen species.  Broccoli sprouts contain large amounts of sulforaphane, which is also found in other cruciferous vegetables including cabbage and kale. (NCI04)
C1425	Eucerin	Drug_Vehicle	Eucerin	A moisturizing skincare formulation used for various skin conditions including dry skin conditions associated with eczema, psoriasis, chapped or chafed skin. (NCI)
C1426	Recombinant_Heregulin	Therapeutic_Epidermal_Growth_Factor	Recombinant Heregulin|Heregulin	A growth factor of the EGF family that induces growth and differentiation of epithelial, glial and muscle cells in culture.  It binds the receptor erbB3 which will heterodimerize with HER-2/erbB2.
C1427	Rogletimide	Non-Steroidal_Aromatase_Inhibitor	Rogletimide|Pyridoglutethimide	An inhibitor of aromatase.
C1428	Stavudine	Reverse_Transcriptase_Inhibitor	Stavudine|1-(2,3-Dideoxy-beta-glycero-pent-2-enofuranosyl)thymine|2',3'-Didehydro-3'-deoxythymidine|3'-Deoxy-2'-thymidinene|BMY-27857|D4T|Didehydrodeoxythymidine|Zerit|d4T|stavudine	A drug that belongs to the family of drugs called nucleoside analogues. It is used to treat infection caused by viruses.
C1429	Vapreotide	Growth_Hormone_Release_Inhibiting_Factor	Vapreotide|Octastatin|vapreotide	A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called somatostatin analogs.
C1430	Cephalomannine	Taxane_Compound	Cephalomannine	A diterpene taxane obtained from the bark and leaves of the yew tree (Taxus brevifolia) and can convert to taxol. (NCI)
C1431	Imiquimod	Immunostimulant	Imiquimod|1H-Imidazo(4,5-c)quinolin-4-amine, 1-(2-methylpropyl)-|4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline|Aldara|IMIQUIMOD|R 837|S 26308|imiquimod	A substance that improves the body's natural response to infection and disease.  It is being studied as a topical agent (something used on the surface of the body) for the prevention of some types of cancer.  It belongs to the family of drugs called biological response modifiers.
C1432	Sulofenur	Diarylsulfonylurea_Compound	Sulofenur|LY186641	A diarylsulfonylurea with potential antineoplastic activity. Sulofenur's antineoplastic mechanism of action is unknown. (NCI04)
C1433	Liarozole	Differentiation_Inducer|Non-Steroidal_Aromatase_Inhibitor	Liarozole|Liarozole Hydrochloride|Liazal|R 75251|liarozole	An anticancer drug that promotes differentiation by increasing the levels of retinoic acid within the tumor.
C1434	Lobaplatin	Platinum_Compound	Lobaplatin|1,2-diammino-methy lcyclobutane-platinum (II) lactate|D-19466|lobaplatin	An anticancer drug that belongs to the family of drugs called platinum compounds.
C1435	RSR-13	Radiosensitizing_Agent	RSR-13|2-(4-(((3,5-Dimethylanilino)Carbonyl)Methyl)Phenoxy)-2-Methylpropionic Acid|Efaproxiral|RSR 13|RSR13	A drug that may increase the effectiveness of radiation therapy.
C1436	Baccatin_III	Taxane_Compound	Baccatin III	A compound obtained from the needles of the Taxus baccata tree that is used as a precursor of paclitaxel. (NCI)
C1437	Therapeutic_CD40-Ligand	Therapeutic_Tumor_Necrosis_Factor_Family_Protein	Recombinant CD40-Ligand|CD154 antigen|CD40L|T-BAM|T-Cell Antigen gp39|TNF-Related Activation Protein|TRAP Ligand|gp39|rhu CD40L	A recombinant therapeutic agent which is chemically identical to or similar to CD40-ligand. CD40-ligand, also known as CD40L/TRAP and CD154, is a type II membrane protein which binds to CD40, a cell surface receptor that belongs to the tumor necrosis factor receptor family; CD40 is expressed on B lymphocytes, monocytes, dendritic cells (DC), hematopoietic progenitors, endothelial cells and epithelial cells. Recombinant CD40-ligand may be used to activate DC ex vivo via CD40 binding; CD40-ligand-activated DC may provide or augment a protective antitumor immunity when administered in dendritic cell cancer vaccines. (NCI04)
C1438	Troxacitabine	Pyrimidine_Antagonist	Troxacitabine|BCH-4556|Troxatyl|troxacitabine	A dioxolane nucleoside analog that is incorporated into the growing DNA chain of cancer cells, causing chain termination and interfering with DNA replication in the cancer cells. (NCI)
C1439	Dolastatin_15	Dolastatin_Compound	Dolastatin 15|L-proline,1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl-.1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))	A depsipeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity.  Less potent than the structurally-related compound dolastatin 10, dolastatin 15 binds weakly to tubulin and blocks microtubule assembly, thereby inhibiting mitosis.  Dolastatin 15 also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers. (NCI04)
C1440	_4-Phenylbutyrate	Differentiation_Inducer|Histone_Deacetylase_Inhibitor	Sodium Phenylbutyrate|4-Phenylbutyrate|4-Phenylbutyric Acid, Sodium Salt|Buphenyl|Phenylbutyrate|Phenylbutyrate Sodium|SODIUM PHENYLBUTYRATE|SPB11|Sodium 4-Phenylbutyrate|Sodium 4-phenylbutyrate|phenylbutyrate	An anticancer drug that belongs to the family of drugs called differentiating agents.
C1441	Carzelesin	DNA_Minor_Groove_Binding_Agent|Miscellaneous_Alkylating_Agent	Carzelesin|2-benzofurancarboximide,N-(2-((1-(chloromethyl)-1,6-dihydro-8-methyl-5-(((phenylamino)carbonyl0oxy0benzo(1,2-b:4,3-b')dipyrrol-3(2H0-yl)carbonyl-1H-indol-5-yl)-6-(diethylamino)-,(S)|U-80244|carzelesin	An anticancer drug that belongs to the family of drugs called alkylating agents.
C1442	Morpholinodoxorubicin	Anthracycline_Antibiotic	Morpholinodoxorubicin|5,12-Naphthacenedione, 7, 8, 9, 10-tetrahydro-6, 8, 11-trihydroxy-8-(hydroxyacetyl)-1-methoxy-10-[[2, 3, 6-trideoxy-3-(4-morpholinyl)-.alpha.-L-lyxo-hexopyranosyl] oxy]-, hydrochloride, (8S-cis)-|morpholino-ADR|morpholino-adriamycin	A semisynthetic derivative of the anthracycline antineoplastic antibiotic doxorubicin.  As an antineoplastic agent, morpholinodoxorubicin is more potent than doxorubicin.  Similar to doxorubicin, morpholinodoxorubicin intercalates into DNA and causes single- and double-strand breaks in DNA via inhibition of topoisomerase I and II.  Unlike doxorubicin, this agent is metabolized in vivo to a DNA-alkylating derivative that forms DNA interstrand cross-links, thereby potentiating its doxorubicin-like cytotoxicity. (NCI04)
C1443	Organochlorine_Compound	Organic_Chemical	Organochlorine Compound|Organochlorines	Organochlorines are a group of compounds belonging to the chlorinated hydrocarbon pesticides (as aldrin, DDT, or dieldrin).  These compounds are believed to associated with many cancers, especially with breast cancer.
C1444	Folate	Pteridines_Folic_Acid_Analogs	Folate|folate	A cofactor for 1-carbon transfer involved with DNA synthesis.
C1445	Hyaluronate	Glycosaminoglycan	Hyaluronate|Sodium Hyaluronate	The sodium salt form of hyaluronic acid, a glucosaminoglycan, a component of connective tissue, skin, vitreous humour, umbilical cord, synovial fluid and the capsule of certain microorganisms contributing to adhesion, elasticity, and viscosity of extracellular substances.
C1446	Radiopharmaceutical_Compound	Pharmacologic_Substance	Radiopharmaceutical Compound|Radiopharmaceuticals|radioactive drugs|radiopharmaceuticals	Drugs containing a radioactive substance that are used in the diagnosis and treatment of cancer and in pain management of bone metastases.
C1447	Barium_Enema	Enema	Barium Enema|LOGISER|Lower GI Series|Lower Gastrointestinal Series|barium enema|lower GI series	A procedure in which a liquid with barium in it is put into the rectum and colon by way of the anus.  Barium is a silver-white metallic compound that helps to show the image of the lower gastrointestinal tract on an x-ray.
C1448	Nafoxidine_Hydrochloride	Nafoxidine	Nafoxidine Hydrochloride|1-[2-[4-(3,4-Dihydro-6-methoxy-2-phenyl-1-naphthalenyl)phenoxy]ethyl]pyrrolidine Hydrochloride|U 11100A|U-11,000A	The hydrochloride salt of the partial estrogen antagonist nafoxidine.  Nafoxidine competes with endogenous estrogen for binding to specific estrogen receptors.  This agent also inhibits angiogenesis in some tissues by blocking the effects of fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF); paradoxically, it may enhance angiogenesis in uterine tissue.  Nafoxidine also induces oxidative stress, protein kinase C and calcium signaling. (NCI04)
C1449	Thorotrast	Contrast_Agent	Thorotrast|Thoria|Thorium Dioxide|Thortrast	Thorium oxide (ThO2). A radiographic contrast agent that was used in the early 1930s through about 1954. High rates of mortality have been linked to its use and it has been shown to cause liver cancer.
C1450	Platinum_Compound	Antineoplastic_Alkylating_Agent|DNA_Adduct_Forming_Agent	Platinum Compound|Platinum Agents
C1451	Oligonucleotide_Primers	Oligonucleotide	Oligonucleotide Primers	Term used to denote short DNA oligonucleotide chains used to prime DNA (and in some cases RNA) synthesis.  The polymerase begins template-directed nucleotide synthesis from the 3' end of the oligonucleotide primer, which is designed to bind to the template at a specific site according to its DNA sequence.
C1452	Enoxaparin	Low_Molecular_Weight_Heparin	Enoxaparin|Enoxaparin Sodium|Lovenox|enoxaparin	A drug used to prevent blood clots.  It belongs to the family of drugs called anticoagulants.
C1453	Dalteparin	Low_Molecular_Weight_Heparin|Matrix_Metalloproteinase_Inhibitor	Dalteparin|Dalteparin Sodium|Fragmin|dalteparin	A drug that helps prevent the formation of blood clots; it belongs to the family of drugs called anticoagulants.
C1454	Bispecific_Antibody	Biological_Agent|Biological_Response_Modifier	Bispecific Antibody|Bispecific Antibodies|bispecific antibodies|bsAb	Antibodies developed in the laboratory to recognize more than one protein on the surface of different cells. Examples include bispecific antibodies 2B1, 520C9xH22, mDX-H210, and MDX447.
C1455	Conjugate_Vaccine	Vaccine	Conjugate Vaccine
C1456	Superantigen	Toxin	Superantigen	Microbial antigens that have in common an extremely potent activating effect on T-cells that bear a specific variable region. Superantigens cross-link the variable region with class II MHC proteins regardless of the peptide binding in the T-cell receptor's pocket. The result is a transient expansion and subsequent death and anergy of the T-cells with the appropriate variable regions.
C1457	Yeast_Artificial_Chromosome	Cloning_Vector	Yeast Artificial Chromosome|YAC|YAC Vector	A cloning vector based upon elements of yeast chromosomes.  At a minimum these include: yeast telomeres, a yeast centromere, and a yeast autonomously replicating sequence (ARS).  Such vectors are propagated in yeast and then transferred into a target eukaryotic cell where the yeast sequences can be recognized and will maintain the molecule through cell division.  These vectors can maintain extremely large amounts of foreign DNA.  YACs are maintained as linear molecules
C1458	Zorubicin	Anthracycline_Antibiotic	Zorubicin|(2S-cis)-Benzoic Acid[1-[4-[3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-1,2,3,4,6,11-hexahydro-2,5,12-trihydroxy-7-methoxy-6,11-dioxo-3-naphthacenyl]ethylidene]hydrazide|Benzoic Acid Hydrazide 3-Hydrazone with Daunorubicin|Benzoyl Hydrazone Daunorubicin|Daunorubicin Benzoylhydrazone Hydrochloride|RP 22050|RP-22050|Rubidazone|Zorubicin Hydrochloride|Zorubicin hydrochloride|Zorubicine	A benzoyl-hydrazone derivative of the anthracycline antineoplastic antibiotic daunorubicin.  Zorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)
C1459	Recombinant_Glial_Cell-Line_Derived_Neurotrophic_Factor	Therapeutic_Neurotrophic_Factor	Recombinant Glial Cell-Line Derived Neurotrophic Factor|GDNF|Glial Cell-Line Derived Neurotrophic Factor	A recombinant therapeutic agent which is chemically identical to or similar to endogenous glial cell line-derived neurotrophic factor (GDNF).  GDNF is a glycosylated, disulfide-bonded homodimer distantly related member of the transforming growth factor-beta superfamily.  This agent is important in the development and maintenance of dopamine neurons, has restorative effects in a wide variety of rodent and primate models of Parkinson disease, and may have utility in the treatment of Parkinson's disease, which is marked by progressive degeneration of midbrain dopaminergic neurons. (NCI04)
C1460	Sorivudine	Dihydropyrimidine_Dehydrogenase_Inhibitor|Nucleic_Acid_Synthesis_Inhibitor	Sorivudine|(+)-1-Beta-D-arabinofuranosyl-5-[(E)-2-bromovi- ny1] uracil|(E)-1-beta-D-arabinofuranosyl-5-(2-bromoethenyl)-2,4(1H,3H)-pyrimidinedione|1-Beta-D-arabinofuranosyl-(E)-5-(2-bromovinyl)uracil|2,4(1H,3H)-pyrimidinedione, 1-beta-D-arabinofuranosyl-5-(2-bromoethenyl)|5-(2-bromovinyl)-1-beta-D- arabinofuranosyluracil|5-Bromovinyl-araU|BV-araU|Bravavir|SQ 32756|Usevir|YN-72	[1-D-arabinofuranosyl-E-(2-bromovinyl)uracil]], a synthetic antimetabolite analogue of Thymidine with antiviral activity against varicella zoster virus, herpes simplex type 1 virus, and Epstein-Barr virus. Sorivudine triphosphate blocks viral DNA replication by inhibiting DNA polymerase activity, but it is not incorporated into elongating viral DNA. Potentially fatal in combination with 5'FU due to inhibition of dihydropyrimidine dehydrogenase by a sorivudine metabolite. (NCI)
C1461	Perillyl_Alcohol	Chemopreventive_Agent|Farnesyl_Transferase_Inhibitor	Perillyl Alcohol|(S)-(-)-Perillyl Alcohol|(S)-(-)-Perillyl alcohol|1-Cyclohexene-1-methanol|4-(1-Methylethenyl)|4-(1-Methylethenyl)-1-cyclohexene-1-methanol|4-Isopropenylcyclohex-1-ene-1-methanol|Dihydrocuminyl Alcohol|POH|Perilla Alcohol|Perilla alcohol|Perillic Alcohol|Perillic alcohol|Perillol|p-Mentha-1,8-dien-7-ol|perillyl alcohol	A drug used in cancer prevention that belongs to the family of plant drugs called monoterpenes.
C1462	Radicicol	Antifungal_Agent	Radicicol|(1aR,2Z,4E,14R,15aR)-8-Chloro-1a,14,15,15a-Tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione|Monorden|RDC	A macrocyclic antifungal antibiotic that inhibits signal-dependent transcriptional activation and induces differentiation in leukemia. (NCI)
C1463	Dihydrolenperone	Unclassified_Chemotherapy_Agent	Dihydrolenperone|1-Butanone, 1-(4-fluorophenyl)-4-[4-[(4-fluorophenyl)hydroxymethyl]-1-piperidi nyl]-|1-Butanone, 1-(4-fluorophenyl)-4-[4-[(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]-|Dihydro-lenperone	A butyrophenone that has been investigated for antineoplastic activity. (NCI04)
C1464	Tirapazamine	Bioreductive_Agent|Radiosensitizing_Agent	Tirapazamine|SR 4233|SR4233|Tirazone|WIN 59075|tirapazamine	A benzotriazine di-N-oxide with potential antineoplastic activity.  Tirapazamine is selectively activated by multiple reductases to form free radicals in hypoxic cells, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death.  This agent also sensitizes hypoxic cells to ionizing radiation and inhibits the repair of radiation-induced DNA strand breaks via inhibition of topoisomerase II. (NCI04)
C1465	Dexniguldipine	Multidrug_Resistance_Modulator|Protein_Kinase_C_Inhibitor	Dexniguldipine|((-)-3-Methyl-5- 3-(4,4-diphenyl-l-piperidinyl)-propyl-l,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-pyridine-3,5-dicarboxylate-hydrochloride)|(R)-Nigaldipine Hydrochloride|(S)-(+)-Watanidipine Hydrochloride|1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid, 3-(4,4-Diphenyl-1-piperidinyl)propyl Methyl Ester, Monohydrochloride (R)-|B 859-35|B859 35|DNIG|Dexniguldipine Hydrochloride|Dexniguldipine.HCl	Dexniguldipine is the R-enantiomer of the dihydropyridine derivate niguldipine. Dexniguldipine showed a binding affinity to the P-glycoprotein and therefore it is to be assumed to block the P-glycoprotein pumping mechanism and to modulate multidrug resistance. (NCI)
C1466	Therapeutic_Fibroblast_Growth_Factor_3	Therapeutic_Fibroblast_Growth_Factor	Recombinant Fibroblast Growth Factor 3|FGF3|Fibroblast Growth Factor 3|HBGF-3|Proto-Oncogene Protein Int-2	A recombinant agent which is chemically identical to or similar to endogenous fibroblast growth factor 3 (FGF-3). FGF-3 is a growth factor for epithelial cells, and is involved in the differentiation of mesodermal structures during embryonic development. (NCI04)
C1467	Therapeutic_Human_Macrophage_Inflammatory_Protein-1_Beta	Therapeutic_Beta_Chemokine	Recombinant Human Macrophage Inflammatory Protein-1 Beta|ACT-2|CCL4|H400is SIS gamma|HuMIP-1-Beta|HuMIP-1b|Human Macrophage Inflammatory Protein-1 Beta|MIP-1 Beta|MIP-1-b|MIP-1Beta|PAT 744|rHuMIP-1-Beta	The recombinant form of endogenous MIP-1 beta chemokine that chemoattracts both neutrophils and monocytes, stimulates macrophages, and stimulates myelopoietic cell growth.(NCI)
C1468	Mycophenolate_Mofetil	Mycophenolate	Mycophenolate Mofetil|MMF|Mycophenolate Mofetil (Cellcept)|mycophenolate mofetil	A drug that is being studied for its effectiveness in preventing graft-versus-host disease and autoimmune disorders.
C1469	In_111_Satumomab_Pendetide	Radioimmunoconjugate	In 111 Satumomab Pendetide|Indium In 111 Satumomab Pendetide|OncoScint CR/OV	A diagnostic imaging agent comprised of 111-Indium label, a chelator (DTPA) and a monoclonal murine antibody (MAb-B72.3) specific for a tumor-associated glycoprotein (TAG-72) frequently expressed by colorectal and ovarian carcinomas. (NCI)
C1470	Loxoribine	Vaccine_Adjuvant	Loxoribine|7-Allyl-8-oxoguanosine	A guanine ribonucleotide derivative with immunomodulator effects.
C1471	Lamivudine	Reverse_Transcriptase_Inhibitor	Lamivudine|3TC|LAMIVUDINE|lamivudine	A drug used to treat infection caused by viruses.
C1472	Bizelesin	DNA_Minor_Groove_Binding_Agent|Miscellaneous_Alkylating_Agent	Bizelesin|Benzo[1,2-b:4,3-b']dipyrrol-4-ol, 6, 6'-[carbonylbis(imino- 1H-indole-5, 2-diylcarbonyl)]bis[8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-, [S-(R*,R*)]|Bizelesin (U-77779)|U-77779|analog of CC-1065|benzo(1,2-b:4,3-b')dipyrrol-4-ol,6,6'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-,(S-(R*,R*))|bizelesin	A synthetic cyclopropylpyrroloindole antineoplastic antibiotic.  Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis.  Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis. (NCI04)
C1473	Recombinant_Soluble_T4	Miscellaneous_Antiviral_Agent	Recombinant Soluble T4	A recombinant soluble form of CD4 that binds to the envelope glycoprotein (gp110) of HIV and inhibits the binding of virus to CD4+ lymphocytes, resulting in an inhibition of virus infectivity. (NCI)
C1474	Filgrastim	Recombinant_Granulocyte_Colony_Stimulating_Factor	Filgrastim|Neupogen|Recombinant Methionyl Human Granulocyte Colony Stimulating Factor|Recombinant-Methionyl Human Granulocyte Colony Stimulating Factor|filgrastim|r-metHuG-CSF	A colony-stimulating factor that stimulates the production of neutrophils (a type of white blood cell). It is a cytokine that belongs to the family of drugs called hematopoietic (blood-forming) agents. Also called granulocyte colony-stimulating factor (G-CSF).
C1475	Ziconotide	Nonnarcotic_Analgesic	Ziconotide|SNX 111|SNX-111|ziconotide	A drug used in the treatment of chronic pain.
C1476	Denileukin_Diftitox	Fusion_Toxin|Immunotoxin	Denileukin Diftitox|DAB(389)-Interleukin-2|DAB(389)IL-2|DAB389 Interleukin-2|DAB389 Interleukin-2 Immunotoxin|DAB389IL-2|DAB389IL2|Interleukin-2 Fusion Protein|Interleukin-2 Fusion Toxin|LY335348|Ontak|denileukin diftitox	A cytotoxic recombinant protein consisting of interleukin-2 (IL-2) protein sequences fused to diphtheria toxin. The IL-2 protein sequence moiety of denileukin difitox directs the cytocidal action of diphtheria toxin to cells that express IL-2 receptors. After the toxin moiety is internalized into target IL-2 receptor-expressing cells, its catalytic domain catalyzes the transfer of the ADP-ribose moiety of NAD to a posttranslationally modified histidine residue of elongation factor 2 (EF-2), called diphthamine. This covalent modification inactivates EF-2 and disrupts polypeptide chain elongation, resulting in cell death. (NCI04)
C1477	Milodistim	Miscellaneous_Biologic_Response_Modifier	Milodistim|GM-CSF/IL-3 Fusion Protein|GM-CSF/IL3 Fusion Protein|Granulocyte-Macrophage Colony Stimulating Factor/Interleukin-3 Fusion Protein|PIXY|PIXY321|Pixykine	A recombinant fusion protein derived from the coding sequences of two growth factors, interleukin-3 (IL-3) and granulocyte-macrophage colony-stimulating factor (GM-CSF).  Milodistim exhibits greater receptor binding affinity and colony stimulating activity than its parent cytokines.  This agent stimulates proliferation of immature hematopoietic cells and allows the stimulation and expansion of multi-lineage hematopoiesis from immature bone marrow progenitor cells. (NCI04)
C1478	QS21	Vaccine_Adjuvant	QS21|NIAID VEU 016|QS-21|QS-21 Adjuvant|Stimulon QS-21 Adjuvant	A plant extract that may improve the ability of the immune system to respond to disease. It is being studied in combination with vaccine therapy.
C1479	ALVAC_Vaccine	Antineoplastic_Vaccine	ALVAC Vaccine	A vaccine based upon the ALVAC Canarypox virus vector.
C1480	Damnacanthal	Tyrosine_Kinase_Inhibitor	Damnacanthal	An alkaloid phytochemical found in the Morinda Citrifolia (Noni) that inhibits the growth of RAS cancer cells. The exact mechanism is unknown but may involve the inhibition of tyrosine kinase. (NCI)
C1481	Amoxicillin-Clavulanic_Acid	Combination_Anti-Infective_Agent	Amoxicillin-Clavulanic Acid	A fixed combination of Amoxicillin and Clavulanic Acid, which inhibits beta-lactamase, a bacterial enzyme that inactivates amoxicillin.(NCI)
C1482	Squalamine	Endothelial_Cell_Inhibitor|Steroid_Compound	Squalamine|3beta-N-1-(N-(3-(4-Aminobutyl))-1,3-diaminopropane)-7alpha,24-dihydroxy-5alpha-cholestane 24-sulfate|MSI-1256F|MSI-1256F (Squalamine lactate)|Squalamine Lactate|Squalamine/MSI-1256F|squalamine lactate	A drug that belongs to the family of drugs called angiogenesis inhibitors. It prevents the growth of new blood vessels into a solid tumor.
C1483	Recombinant_Betacellulin	Therapeutic_Epidermal_Growth_Factor	Recombinant Betacellulin|Beta Cellulin	A recombinant form of the endogenous Betacellulin, a member of the Epidermal Growth Factor family that is expressed primarily in the pancreas and induces differentiation of a pancreatic acinar cell line.
C1484	Tyrphostin_A25	Tyrphostin_Compound	Tyrphostin A25|4,5-Trihydroxybenzylidene malononitrile|AG 82	A member of the tyrphostin family of tyrosine kinase inhibitors that competitively binds and inhibits epidermal growth factor receptor and GTPase activity of transducin and induces apoptosis in human leukemic cell lines. (NCI)
C1485	Rubitecan	Camptothecin_Analogue	Rubitecan|9-NC|9-Nitro-20 (S-)Camptothecin|9-nitrocamptothecin|Camptogen|Nitro camptothicin|Nitrocamptothecin|Orathecin|RFS 2000|nitrocamptothecin	A semisynthetic agent related to camptothecin with potent antitumor and antiviral properties.  Rubitecan binds to and inhibits the enzyme topoisomerase I and induces protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells; this agent also prevents repair of reversible single-strand DNA breaks. (NCI04)
C1486	GEM_91	Phosphorothioate_Oligonucleotide	GEM 91|Gene Expression Modulator 91|Trecovirsen	A 25-mer antisense oligodeoxynucleotide phosphorothioate.  GEM-91 is complementary to the gag mRNA of human immunodeficiency virus type 1 (HIV-1), resulting in HIV-1 replication inhibition. (NCI)
C1487	Lavendustin_C	Tyrosine_Kinase_Inhibitor	Lavendustin C	A compound that inhibits calmodulin kinase II and p60. (NCI)
C1488	Aminocamptothecin	Camptothecin_Analogue	Aminocamptothecin|9-AC|9-Amino-20-(S)-camptothecin|9-Aminocamptothecin|9-amino-20(S)-camptothecin|9-amino-20-camptothecin|9-amino-CPT|9-amino-camptothecin|9-aminocamptothecin|aminocamptothecin	A water-insoluble camptothecin derivative.  Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand DNA breakages.  Because the terminal lactone ring of aminocamptothecin required for the agent's antitumor activity spontaneously opens under physiological conditions to an inactive carboxy form, the drug must be administered over an extended period of time to achieve effective cytotoxicity. (NCI04)
C1489	Therapeutic_Interleukin-13	Therapeutic_Interleukin	Recombinant Interleukin-13|IL-13|Interleukin 13	The recombinant analogue of an endogenous cytokine interleukin 13 with potential antineoplastic activity. Produced by lymphocytes and exhibiting a variety of functions, interleukin-13 (therapeutic) inhibits DNA synthesis and regulates inflammatory and immune responses. In animal models, this agent has been shown to kill tumor cells both directly and indirectly by activating the host immune system at the tumor site. (NCI04)
C1490	Taxane_Compound	Tubulin_Binding_Agent	Taxane Compound|Taxanes|taxanes	Anticancer drugs that inhibit cancer cell growth by stopping cell division. Also called antimitotic or antimicrotubule agents or mitotic inhibitors.
C1491	Tyrphostin_AG_879	Tyrphostin_Compound	Tyrphostin AG 879|AG 879|a-Cyano-(3,5-Di-T-Butyl-4-Hydroxy) Thiocinnamide	A compound that selectively inhibits protein tyrosine kinase and nerve growth factor-dependent tyrosine phosphorylation. (NCI)
C1492	Sargramostim	Therapeutic_Granulocyte-Macrophage_Colony-Stimulating_Factor	Sargramostim|Leukine|Prokine|Sagramostim|rhu GM-CFS|sargramostim	A colony-stimulating factor that stimulates the production of white blood cells, especially granulocytes and macrophages, and cells (in the bone marrow) that are precursors of platelets. It is a cytokine that belongs to the family of drugs called hematopoietic (blood-forming) agents. Also called granulocyte-macrophage colony-stimulating factor (GM-CSF).
C1493	Satraplatin	Platinum_Compound	Satraplatin|(OC-6-43)-bis(acetato)amminedichloro(cyclohexylamine)platinum|(OC-6-43)-bis(acetato-O)amminedichloro(cyclohexanamine)platinum|BMS-182751|BMY-45594|JM-216|platinum,bis(acetato-O)amminedichloro(cyclohexanamine)-,(OC-6-43)	A platinum compound used in chemotherapy.
C1494	Arcitumomab	Monoclonal_Antibody|Monoclonal_Antibody_for_Clinical_Diagnosis	Arcitumomab|CEA-Scan|IMMU-4|MA IMMU-4|MA IMMU-4 F(AB)2|anti-Carcinoembryonic Antigen Monoclonal Antibody Fab' Fragment	A murine IgG monoclonal Fab fragment antibody labeled with technetium-99m directed against carcinoembryonic antigen (CEA), a protein that is overexpressed by many tumor cell types.  For tumors that overexpress CEA, arcitumomab may be used as an adjunct diagnostic imaging tool to obtain prognostic information following resection and to monitor for recurrent disease. (NCI04)
C1495	Intoplicine	Topoisomerase-II_Inhibitor|Topoisomerase-I_Inhibitor	Intoplicine|7H-benzo(e)pyrido(4,3-b)indol-3-ol, 11-((3-(dimethylamino)propyl)amino)-8-methyl|intoplicine	An anticancer drug that belongs to the family of drugs called topoisomerase inhibitors.
C1496	DOTMP	Chelating_Agent	DOTMP|1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetramethylene-Phosphonic Acid	A bone-seeking chelating agent.  Has been used as a radiopharmaceutical in complexes with radioactive metals for bone marrow ablation.
C1497	SR_49059	Vasopressin_Antagonist	SR 49059|1-(5-Chloro-3-(2-chlorophenyl)-1-(3,4-dimethoxybenzenesulfonyl)-3-hydroxy-2,3-dihydro-1H-indole-2-carbonyl)pyrrolidine-2-carboxamide|SR49059	An anticancer drug that inhibits a hormone growth factor responsible for stimulating some cancer cells to multiply.
C1498	Aldesleukin	Therapeutic_Interleukin-2	Aldesleukin|Proleukin|Recombinant Human IL-2|Recombinant Human Interleukin 2|Recombinant Human Interleukin-2|aldesleukin	A laboratory-made colony-stimulating factor that stimulates the production of blood cells, especially platelets, during chemotherapy. It is a cytokine that belongs to the family of drugs called hematopoietic (blood-forming) agents. Also called interleukin-2 or IL-2.
C1499	_2_Fluoro-2_3_Dideoxyadenosine	Reverse_Transcriptase_Inhibitor	2'-Fluoro-2',3'-Dideoxyadenosine|2'-Beta-Fluoro-2',3'-Dideoxyadenosine	A fluoro-substituted analog of dideoxyadenosine that inhibits reverse transcriptase, thereby inhibiting telomerase activity and subsequent cell proliferation.
C1500	Penicillin_Antibiotic	Antibiotic	Penicillin Antibiotic|penicillin	An antibiotic drug used to treat infection.
C1501	Phenyl_Acetate	Differentiation_Inducer	Phenyl Acetate|Acetic Acid Phenyl Ester|Acetylphenol|Phenyl acetate|Phenylacetate|Sodium Phenylacetate|Sodium phenylacetate|phenylacetate	A drug being studied in the treatment of cancer.
C1502	Fiber	Dietary_Component	Fiber|fiber	Substances in plant foods (fruits and vegetables) that are not digested or absorbed by the gastrointestinal tract.  Fiber is classified into two categories, soluble and insoluble fiber.  Due to increasing the rate of gastrointestinal digestion and possible absorption of cancer causing agents, fiber may possess chemopreventive properties. (NCI)
C1503	Deoxyadenosine	Nucleoside	Deoxyadenosine	A purine nucleoside component of DNA comprised of adenosine linked by its N9 nitrogen to the C1 carbon of deoxyribose.(NCI)
C1504	Therapeutic_Epidermal_Growth_Factor	Therapeutic_Growth_Factor	Recombinant Epidermal Growth Factor	A recombinant therapeutic agent which is chemically identical to or similar to endogenous epidermal growth factor (EGF).  As a mitogen, EGF stimulates the proliferation of epidermal, epithelial, and embryonic cells.  This agent is also a strong chemoattractant for fibroblasts and epithelial cells and is an important factor mediating angiogenesis and wound healing.  EGF and EGF-like factors have been shown to promote regeneration of the epidermis and the generation of granulation tissues following severe burns and, when locally administered, may improve healing of injured corneal tissues. (NCI04)
C1505	Nutritional_Supplement	Food_and_Food_Product	Nutritional Supplement|Dietary Supplement|SUPP|Supplements	Oral preparations containing dietary ingredient(s) intended to supplement the diet.  Dietary ingredients include vitamins, minerals, herbs, amino acids, extracts and metabolites.(NCI)
C1506	Opioid	Analgesic_Agent	Opioid|Narcotic|narcotic|opioids	A class of synthetic chemicals/drugs similar to opiates (opium derivatives) with analgesic properties.  Due to binding to opiate receptors, opioids mimic opiate activity on neurons, various cells (i.e. lymphocytes), pain suppression and other neurobehavioral activity. (NCI)
C1507	Prazosin_Hydrochloride	Prazosin	Prazosin Hydrochloride|Alpress LP|CP-12299-1|Duramipress|Eurex|Hypovase|Minipress|PRAZOSIN HYDROCHLORIDE|Peripress|Prazosin hydrochloride|Sinetens	A synthetic piperazine derivative with hypotensive antiadrenergic properties, Prazosin Hydrochloride reduces peripheral resistance and relaxes vascular smooth muscles as a selective adrenergic alpha-1 antagonist by a mechanism not completely known. It is used in the treatment of heart failure, hypertension, pheochromocytoma, Raynaud's syndrome, prostatic hypertrophy, and urinary retention. (NCI04)
C1508	Retrotransposon	DNA_Insertion_Elements	Retrotransposon|Transposon	Retrotransposons are transposable DNA elements (transposons) that employ retroviral-like reverse transcription during the process of transposition: retrotransposon DNA is first transcribed into an RNA template, then reverse transcribed into DNA, and then inserted into a new genomic site.
C1509	Neuroprotective_Agent	Chemoprotective_Agent	Neuroprotective Agent|Neuroprotectants|Neuroprotective Drugs
C1510	DNA_Adduct	Mutagen	DNA Adduct|Carcinogen-DNA Adducts
C1511	Radioimmunoconjugate	Immunoconjugate|Radiopharmaceutical_Compound	Radioimmunoconjugate|Radiolabeled Antibodies	Radioimmunoconjugates, monoclonal antibodies conjugated to radioactive-emitting molecules. The advantage to using radioimmunoconjugates is that radiotherapy is targeted to the tumor cells, thereby limiting toxic effects on normal cells. Tumor eradication is accomplished by the antibody-mediated effects as well as by the cytotoxic activity of the radiation. Beta particles are tumoricidal over a distance of many adjacent cell diameters and achieve killing of antigen-negative tumor cells that would not be eliminated by the antibody alone. (From www.medscape.com)
C1512	Immunoconjugate	Biological_Response_Modifier	Immunoconjugate|Icon
C1513	Analog	Drugs_and_Chemicals_Functional_Classification	Analog|Analogue|analog	A synthetic chemical which structurally or functionally resembles a naturally occurring compound. (NCI)
C1514	Agonist	Drugs_and_Chemicals_Functional_Classification	Agonist	An gent that has affinity for a receptor and intrinsic activity at that receptor.(NCI)
C1515	Ranimustine	Nitrosourea_Compound	Ranimustine|Cymer|Cymerin|MCNU|Ranomustine|alpha-D-glucopyranoside, methyl 6-((((2-chloroethyl)nitrosoamino)carbonyl)amino)-6-deoxy-|methyl 6-((((2-chloroethyl)nitrosoamino)carbonyl) amino)-6-deoxy-alpha-D-glucopyranoside|methyl 6-(3-(2-chloroethyl)-3-nitrosoiureido)-6-deoxy-alpha-D-glucopyranoside|methyl 6-(3-(2-chloroethyl)-3-nitrosoureido)-6-deoxy-alpha-D-glucopyranoside	A chloroethylnitrosourea derivative that inhibits proliferation and growth of tumor cells by alkylation and cross-linkage of DNA strands of tumor cells. (NCI)
C1516	Lisofylline	Miscellaneous_Chemoprotective_Agent	Lisofylline|CT 1501R|CT-1501R|Lisofenicol|lisofylline	A drug that may protect healthy cells from chemotherapy and radiation without inhibiting the effects of these therapies on tumor cells.
C1517	Distamycin	DNA_Minor_Groove_Binding_Agent|Distamycin_Antibiotic	Distamycin|DISTAMYCIN A|Distamycin A	An oligopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces distallicus.  Distamycin preferentially binds to adenine-thymine (A-T) rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and RNA transcription.  In addition to antitumor effects, distamycin also possesses antiviral and antiprotozoal activities and is used as a chromosome dye. (NCI04)
C1518	Raloxifene	Selective_Estrogen_Receptor_Modulator	Raloxifene|Keoxifene|LY 139481|[6-Hydroxy-2-(4-hydroxyphenyl)-benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone|raloxifene	A drug that belongs to the family of drugs called selective estrogen receptor modulators (SERMs) and is used in the prevention of osteoporosis in postmenopausal women. Raloxifene is also being studied as a cancer prevention drug.
C1519	Roquinimex	Angiogenesis_Activator_Inhibitor|Immunostimulant	Roquinimex|1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-3-quinolinecarboxanilide|1,2-Dihydro-4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide|FCF 89|LS 2616|Linomide|N-Phenyl-N-methyl-1,2-dihydro-4-hydroxy-1-methyl-2-oxoquinoline-3-carboxamide	A quinoline-3-carboxamide with potential antineoplastic activity.  Roquinimex inhibits endothelial cell proliferation, migration, and basement membrane invasion; reduces the secretion of the angiogenic factor tumor necrosis factor alpha by tumor-associated macrophages (TAMs); and inhibits angiogenesis.  This agent is also an immune modulator that appears to alter cytokine profiles and enhance the activity of T cells, natural killer cells, and macrophages. (NCI04)
C1520	Teloxantrone	Anthrapyrazole_Antibiotic	Teloxantrone|Anthra(1,9-cd)pyrazol-6(2H)-one,7,10-dihydroxy-2-(2-((2-hydroxyethyl)amino)ethyl)-5-((2-(methylamino)ethyl)amino|CI-937|DUP 937|Moxantrazole|Moxantrazole Hydrochloride	An anthrapyrazole antineoplastic antibiotic.  Teloxantrone intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair, as well as RNA and protein synthesis. (NCI04)
C1521	Losoxantrone	Anthrapyrazole_Antibiotic	Losoxantrone|Biantrazole|CI-941|DuP 941|losoxantrone	An anticancer drug that belongs to the family of drugs called antipyrazoles.
C1522	Troglitazone	Anti-diabetic_Agent|Differentiation_Inducer	Troglitazone|5-[4-[(6-Hydroxy-2,5,7,8-tetramethylchroman-2-yl)methoxy]benzyl]-2,4-thiazolidinedione|5-[[4-[4(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl\-2,4-thiazolidinedione|CI-991|CS-045|Rezulin|Romozin|troglitazone	A drug used in diabetes treatment that is being studied for its effect on reducing the risk of cancer cell growth in fat tissue.
C1523	Lanreotide	Growth_Hormone_Release_Inhibiting_Factor	Lanreotide|Angiopeptin|BIM-23014|DC 13116|Dermopeptin|Ipstyl|L-Threoninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-, cyclic (2-7)-disulfide|Somatulina|Somatuline	A heptapeptide synthetic somatostatin octapeptide analog that binds preferentially to pituitary somatostatin receptors.
C1524	Liarozole_Fumarate	Differentiation_Inducer|Non-Steroidal_Aromatase_Inhibitor	Liarozole Fumarate|R85246	An orally-active fumarate salt of liarozole, an agent with potential antineoplastic.  As a retinoic acid metabolism blocking agent (RAMBA), liarozole fumarate inhibits cytochrome P450 dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation.  This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis. (NCI04)
C1525	RG_12915	Antiemetic_Agent	RG 12915|RG-12915|RG12915	A 5-hydroxytryptamine-3 (5-HT3) antagonist with antiemetic activity.
C1526	Docetaxel	Taxane_Compound	Docetaxel|DOCETAXEL|N-Debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol|RP56976|Taxotere|[2aR-[2a Alphaa,4beta,4a beta,6beta,9alpha,(alphaR*,betaS*),-11alpha,12alpha,12a alpha,12b alpha]]-beta-[[(1,1-dimethylethoxy)carbonyl]-amino]-alpha-hydroxybenzemepropanoic Acid 12b-(Acetyloxy)-12(benzyloxy)-2a,3,4,4a,5,6,8,10,11,12,12a,12b-dodecahydeo-4,-6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester|docetaxel	A semi-synthetic, second-generation taxane derived from a compound found in the European yew tree, Taxus baccata.  Docetaxel displays potent and broad antineoplastic properties; it binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death.  This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response.  Docetaxel has been studied for use as a radiation-sensitizing agent. (NCI04)
C1527	Letrozole	Non-Steroidal_Aromatase_Inhibitor	Letrozole|CGS 20267|Femara|LETROZOLE|letrozole	A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure.  As a third-generation aromatase inhibitor, letrozole selectively and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis.  In estrogen-dependent breast cancers, anastrozole may inhibit tumor growth. (NCI04)
C1528	Risedronate_Sodium	Biphosphonate	Risedronate Sodium|Actonel|NE-58095|RISEDRONATE SODIUM|Risedronate|Risedronate Sodium (Actonel)|risedronate	(ris-ED-roe-nate) A substance that is being studied in the prevention and treatment of osteoporosis. It belongs to the family of drugs called bone resorption inhibitors.
C1529	Batimastat	Matrix_Metalloproteinase_Inhibitor	Batimastat|(2R,3S)-N{4}-Hydroxy-N{1}-[(1S)-2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl]-2-(2-methylpropyl)-3-[(2-thienylthio)methyl]butanediamide|BB-94|BB94|Butanediamide, N4-hydroxy-N1-(2-(methylamino)-2-oxo-1-(phenylmethyl)ethyl)-2-(2-methylpropyl)-3-((2-thienylthio)methyl)-, (2R-(1(S*),2R*,3S*))-|[4-(N-Hydroxyamino)-2R-isobutyl-3S-(2-thienylthiomethyl)-succinyl]-L-phenylalanine-N-methylamide|[4-(N-Hydroxyamino)-2R-isobutyl-3S-(thiophen-2-ylthiomethyl)-succinyl]-L-phenylalanine-N-methylamide|batimastat	A synthetic hydroxamate with potential antineoplastic activity.  Batimastat binds covalently to the zinc ion in the active site of matrix metalloproteinases (MMPs), thereby inhibiting the action of MMPs, inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. (NCI04)
C1530	Piperacillin-Tazobactam	Extended_Spectrum_Penicillin_Antibiotic	Piperacillin-Tazobactam|PIPER/TAZO|Piperacillin/Tazobactam|Zosyn|piperacillin-tazobactam	A combination of drugs used to fight infections in people who have cancer. Piperacillin is a synthetic penicillin; tazobactam enhances the effectiveness of piperacillin.
C1531	Therapeutic_Eotaxin	Therapeutic_Beta_Chemokine	Recombinant Eotaxin|Eotaxin	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous chemokine eotaxin, a member of the C-C cytokine family which is chemotactic for eosinophils.  CD4+ T cells which secrete eotaxin may induce regression of tumor metastases.  This effect of eotaxin, in combination with its chemoattractant properties, indicates a potential role for eotaxin in cancer immunotherapy. (NCI04)
C1532	Gutolactone	Quassinoid_Agent	Gutolactone	A quassinoid phytochemical isolated from the plant Simaba guianensis with potential antineoplastic and antimalarial activities. (NCI04)
C1533	Pemetrexed	Folate_Antagonist|Thymidylate_Synthase_Inhibitor	Pemetrexed|Alimta|L-Glutamic Acid, N-(4-(2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo(2,3-d)pyrimidin-5-yl)ethyl)benzoyl)|LY231514|MTA|Multitargeted Antifolate|N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium Salt|Pemetrexed (Alimta) (LY231514)|Pemetrexed Disodium|pemetrexed disodium	A synthetic pyrimidine-based antifolate. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. (NCI04)
C1534	Methionine_C_11	Radioconjugate	Methionine C 11|Methionine C11	A synthetic amino acid radiolabeled with carbon-11. Acting as a methyl donor, methionine C 11 is incorporated into macromolecules, where it serves as a positron emission tomography (PET) imaging agent for detecting tumors with high rates of protein synthesis.
C1535	Bruceanol_D	Bruceanol_Agent	Bruceanol D|Picras-3-en-21-oic Acid, 15-((3,4-dimethyl-1-oxo-2-pentenyl)oxy)-13,20-epoxy-1,11,12-trihydroxy-2,16-dioxo-, Methyl Ester, (1beta,11beta,12alpha,15beta(E))-	A quassinoid phytochemical isolated form the plant Brucea antidysenterica with potential antineoplastic activity. (NCI04)
C1536	Bruceanol_E	Bruceanol_Agent	Bruceanol E|Picrasan-21-oic Acid, 15-((3,4-dimethyl-1-oxo-2-pentenyl)oxy)-13,20-epoxy-1,11,12-trihydroxy-2,16-dioxo-, Methyl Ester, (1beta,11beta,12alpha,15beta(E))-	A quassinoid phytochemical isolated from the plant Brucea antidysenterica with potential antineoplastic activity. (NCI04)
C1537	Bruceanol_F	Bruceanol_Agent	Bruceanol F|Picras-2-en-21-oic Acid, 15-((3,4-dimethyl-1-oxo-2-pentenyl)oxy)-13,20-epoxy-2,11,12-trihydroxy-1,16-dioxo-, Methyl Ester, (11beta,12alpha,15beta(E))-	A quassinoid phytochemical isolated from the plant Brucea antidysenterica with potential antineoplastic activity. (NCI04)
C1538	Therapeutic_Fas_Ligand	Therapeutic_Tumor_Necrosis_Factor_Family_Protein	Recombinant Fas Ligand|FAS-Ligand|Fas Ligand|Fas-L	A recombinant agent, which is chemically identical to or similar to the endogenous protein Fas ligand, a protein related to tumor necrosis factor (TNF) with potential antineoplastic activity.  Fas ligand binds to the Fas receptor, thereby activating caspases and inducing apoptosis. (NCI04)
C1539	Tezacitabine	Ribonucleotide_Reductase_Inhibitor	Tezacitabine|FMdC|MDL 101,731	A drug that belongs to a family of drugs called ribonucleotide reductase inhibitors.
C1540	Tyrphostin_A46	Tyrphostin_Compound	Tyrphostin A46|AG 99	A protein tyrosine kinase inhibitor that selectively inhibits EGFR kinase, involved in signaling pathways. (NCI)
C1541	LR-3001	Phosphorothioate_Oligonucleotide	LR-3001|Antisense c-Myb Oligodeoxynucleotide|OL(1)p53|c-MYB Antisense|c-MYB Antisense Oligodeoxynucleotide|c-Myb Antisense OND|c-Myb LR-3001	A 24 base pair phosphorothioate oligonucleotide targeting codons 2-9 of the c-MYB gene, resulting in suppression of c-MYB protein expression.
C1542	KW_2189	Duocarmycin_Antibiotic	KW 2189|Benzo(1,2-b:4,3-b')dipyrrole-1-carboxylic Acid, 8-(bromomethyl)-3,6,7,8-tetrahydro-2-methy-4-(((4-methyl-1-piperazinyl)carbonyl)oxy)-6-((5,6,7,-trimethoxy-1H-indol-2-yl)carbonyl)-, Methyl Ester (S)|Duocamycin B2 Analog|KW-2189|KW2189	A semisynthetic anticancer drug that belongs to the family of drugs called antitumor antibiotics.
C1543	Peptide_946	Tumor_Specific_Peptide	Peptide 946|peptide 946	A protein that causes white blood cells to recognize and destroy melanoma cells.
C1544	Depsipeptide	Depsipeptide_Antibiotic|Histone_Deacetylase_Inhibitor	Antibiotic FR 901228|FK228|FR901228|L-Valine, N- (3-hydroxy-7-mercapto-1-oxo-4-heptenyl)valyl- cysteinyl-2, 3-didehydro-2-aminobutanoyl-,.xi.-lactone, cyclic (1.fwdarw.2)-disulfide|L-Valine, N-(3-Hydroxy-7-Mercapto-1-Oxo-4-Heptenyl)-D-Valyl-D-Cysteinyl-(Z)-2,3 -Didehydro-2-Aminobutanoyl-, xi-Lactone, Cyclic (1-2)-Disulfide, (S-(E))-|N-[(3S,4E-3-Hydroxy-7-mercapto-1-oxo-4-heptenyl]-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoyl-L-valine, (4->1) Lactone, Cyclic|depsipeptide	A bicyclic depsipeptide antibiotic isolated from the bacterium Chromobacterium violaceum.  After intracellular activation, depsipeptide binds to and inhibits histone deacetylase, thereby affecting the regulation of gene expression and inducing cell differentiation, cell cycle arrest, and apoptosis.  This agent also inhibits hypoxia-induced angiogenesis and depletes several HSP90-dependent oncoproteins. (NCI04)
C1545	Therapeutic_Interleukin-15	Therapeutic_Interleukin	Recombinant Interleukin-15|IL15|Interleukin 15
C1546	Cryptophycin	Tubulin_Binding_Agent	Cryptophycin|10-((3-Chloro-4-methoxyphenyl)methyl)-6-methyl-3-(2-methylpropyl)-16-(1-(3-phenyloxiranyl)ethyl)-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetrone|Cryptophycin 1	The cryptophycins are a family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. The mechanism of anticancer activity of the cryptophycins has been associated with their destabilization of microtubules and induction of bcl-2 phosphorylation leading to apoptosis. Cryptophycins demonstrated activity against the wide spectrum of solid tumors including those that overexpress the multidrug resistance efflux pump P-glycoprotein. (NCI)
C1547	Compound_32	Tyrosine_Kinase_Inhibitor	Compound 32|4-(3'-bromoanilino)-6,7-dimethoxyquinazoline|PD 153035|ZM 252868	A protein tyrosine kinase inhibitor that has specific activity for the epidermal growth factor receptor. (NCI)
C1548	Therapeutic_OX40_Ligand	Therapeutic_Tumor_Necrosis_Factor_Family_Protein	Recombinant OX40 Ligand|OX40 ligand|OX40L	A recombinant agent, which is chemically identical to or similar to the endogenous protein Fas ligand OX40, a member of the tumor necrosis factor (TNF) family.  Expressed by antigen presenting cells (APC), OX40 ligand binds to the OX40 receptor on CD4 T-cells, thereby priming antigen-specific activation of CD4 T-cells and inducing CD4 T-cell secretion of interleukin 4 (IL-4). (NCI04)
C1549	BR96_sFv-PE40	Immunotoxin	BR96 sFv-PE40|SGN-10	A fusion protein consisting of Fv fragments of the BR96 monoclonal antibody and a binding defective version of Pseudomonas exotoxin (PE40).  The BR96 monoclonal antibody specifically binds to cells that overexpress Lewis Y-related carbohydrate antigen, allowing endosomal internalization of PE40.  After internalization, PE40 alters ADP-ribosylation of ribosomal elongation factor 2, thereby inactivating elongation factor 2 and inhibiting protein synthesis. (NCI)
C1550	Fat-Soluble_Vitamin	Vitamin	Fat-Soluble Vitamin	A vitamin that is soluble in fat solvents and oils (lipo-soluble). Fat-soluble vitamins include vitamins A, D, E, K, F. Absorbed with ingested dietary fat, fat-soluble vitamins are stored in moderate amounts from the gastrointestinal tract. Present in minute amounts in various foods, these vitamins are essential to maintaining normal metabolism and biochemical functions; fat malabsorption may result in fat-soluble vitamin deficiencies. Fat-soluble vitamins are found in many types of foods and may be supplemented with pharmaceutical formulations. (NCI04)
C1551	Water-Soluble_Vitamin	Vitamin	Water-Soluble Vitamin	Vitamins that are freely soluble in water.
C1552	Vasopressin_Tannate_in_Oil	Therapeutic_Vasopressin	Vasopressin Tannate in Oil	An oil based formulation of Vasopressin, which could be administered intramuscularly. (NCI)
C1553	Thyroid_Agent	Therapeutic_Hormone	Thyroid Agent	Compounds that influence the function of the thyroid hormone through replacement, inhibition or stimulation. (NCI)
C1554	Edrecolomab	Monoclonal_Antibody	Edrecolomab|MOAB 17-1A (Panorex)|Monoclonal Antibody 17-1A|Panorex|edrecolomab	A murine monoclonal IgG2a antibody to tumor-associated epithelial cell adhesion molecule (EpCAM, or 17-1A) antigen. Edrecolomab attaches to EpCAM, a human cell surface glycoprotein that is found on normal epithelial cells and some tumor cells, such as those of colon and breast carcinomas. Upon binding, this agent recruits the body's immune effector cells, which may exhibit antitumor cytotoxicity. (NCI04)
C1555	Doxorubicin_Hydrochloride_Liposome	Doxorubicin	Doxorubicin Hydrochloride Liposome|(8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-a-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-tri-hydroxy-1-methoxy-5,12-naphthacenedione Hydrochloride|Caelyx|DOX-SL|DOXIL|Doxil|Doxilen|Doxorubicin Citrate|Doxorubicin HCl Liposome|Doxorubicin Hydrochloride Liposomal|Doxorubicin Hydrochloride Liposome Injection|Doxorubicin Liposome|Evacet|LipoDox|Liposomal Adriamycin|Liposomal Doxorubicin|Liposomal Doxorubicin (Doxil)|Liposomal Doxorubicin (Liposome Company)|Liposomal Doxorubicin Hydrochloride|Liposomal-Encapsulated Doxorubicin|Myocet|Pegylated Doxorubicin HCl Liposome|Pegylated Liposomal Doxorubicin|Pegylated Liposomal Doxorubicin Hydrochloride|S-Liposomal Doxorubicin|Stealth Liposomal Doxorubicin|Sterically Stabilized Liposome|TLC D-99	A liposome-encapsulated form of the hydrochloride salt of the anthracycline antineoplastic antibiotic doxorubicin.  Liposomal delivery of doxorubicin HCL improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects.  Doxorubicin intercalates into DNA and interacts with topoisomerase II, consequently inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. (NCI04)
C1556	Purine_Antagonist	Antimetabolite	Purine Antagonist|Purine Inhibitors	Class of drugs that affect the metabolism and utilization of purines.
C1557	Pyrimidine_Antagonist	Antimetabolite	Pyrimidine Antagonist	Class of drugs that affect the metabolism and utilization of pyrimidines.
C1558	Extended_Spectrum_Penicillin_Antibiotic	Penicillin_Antibiotic	Extended Spectrum Penicillin Antibiotic	A group of penicillins with extended gram-negative bacterial coverage, including Ticarcillin, Piperacillin, Carbenicillin, Timentin and Mezlocillin. (NCI)
C1559	L-Leucovorin	Folic_Acid_Derivative	L-Leucovorin|CL-307,782|Calcium levoleucovorin|Elvorine, Isovorin, Levofolene, Levorin|Isovorin|L-5-Formyltetrahydrofolate|Levofolinate|Levofolinate calcium|Levofolinic acid|Levoleucovorin	The active l-isomer of the racemic mixture of the 5-formyl derivative of tetrahydrofolic acid. Metabolically active, l-leucovorin, also known levoleucovorin, does not require bioactivation by dihydrofolate reductase, an enzyme inhibited by folic acid antagonists. This agent may enhance the effects of fluoropyrimidines by stabilizing their binding to the enzyme thymidylate synthase. (NCI04)
C1560	Brequinar	Dihydroorotate_Dehydrogenase_Inhibitor|Pyrimidine_Antagonist	Brequinar|6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic Acid|Bipenquinate	A synthetic quinolinecarboxylic acid analogue with antineoplastic properties.  Brequinar inhibits the enzyme dihydroorotate dehydrogenase, thereby blocking de novo pyrimidine biosynthesis.  This agent may also enhance the in vivo antitumor effect of antineoplastic agents such as 5-FU. (NCI04)
C1561	Monoclonal_Antibody_Lym-1	Monoclonal_Antibody	Monoclonal Antibody Lym-1|IgG2a murine monoclonal antibody Lym-1|Lym-1|MoAb Lym-1|Monoclonal Antibody Lym-1, IgG2a Murine|Murine Monoclonal Antibody (LYM-1)	A murine IgG2a monoclonal antibody directed against the HLA-Dr10 protein, a cell surface marker present on over eighty percent of lymphoma cells.  When conjugated with a radioactive isotope, Lym-1 monoclonal antibody selectively transports the cytotoxic radioisotope to HLA-Dr10-expressing tumor cells, thereby sparing healthy B-cells and normal tissues.  This agent also mediates antibody-dependent cytotoxicity thereby promoting Raji B-lymphoid cell lysis by human neutrophils. (NCI04)
C1562	Re_186_Hydroxyethylidene_Diphosphonate	Adjuvant_Analgesic|Radioconjugate	Re 186 Hydroxyethylidene Diphosphonate|186Re-Etidronate|Re-186 HEDP|Rhenium Re 186 Etidronate|Rhenium-186 HEDP|Rhenium-186 Hydroxyethylidene Diphosphonate	A beta particle-emitting radiopharmaceutical.  It localizes in metastatic foci in bone.
C1563	Dexverapamil	Calcium_Channel_Blocker	Dexverapamil|R Verapamil|R-Verapamil|R-Verapamil Hydrochloride	The R-enantiomer of the calcium channel blocker verapamil. Dexverapamil competitively inhibits the multidrug resistance efflux pump P-glycoprotein (MDR-1), thereby potentially increasing the effectiveness of a wide range of antineoplastic drugs which are inactivated by MDR-1 mechanisms.  This agent exhibits decreased calcium antagonistic activity and toxicity compared to racemic verapamil. (NCI04)
C1564	Pyrazoloacridine	Acridine|Topoisomerase-II_Inhibitor	Pyrazoloacridine|pyrazoloacridine	A 9-methoxy acridine compound containing a reducible 5-nitro substituent.  Pyrazoloacridine appears to intercalate into DNA and inhibit RNA synthesis, DNA synthesis, and the activities of topoisomerases I and II, thereby causing cytotoxicity. (NCI04)
C1565	Aloe_Vera_Gel	Topical_Preparation	Aloe Vera Gel	Obtained as a preparation of leaf pulp from the parenchymal tissue of Aloe vera (Liliaceae) and containing carbohydrate polymers, such as glucomannans or pectic acid; various vitamins and essential amino acids; as well as other organic and inorganic compounds, Aloe Vera Gel is used internally or externally for sunburn, skin problems, insect bites, ulcers, arthritis, constipation, and as an immune system enhancer. (NCI04)
C1566	Amphotericin_B-Lipid_Complex	Amphotercin_B	Amphotericin B-Lipid Complex|Abelcet|Lipid Complex, Amphotericin B	Consists of the macrolide antibiotic Amphotericin B complexed with dimyristoyl phosphatidylcholine and dimyristoyl phosphatidylglycerol, formulated to provide lower toxicity with efficacy similar to the parent compound, Amphotericin B.  Amphotericin B binds to ergosterol altering cell membrane integrity with subsequent cell death. (NCI)
C1567	Strontium-89	Adjuvant_Analgesic|Radioisotope	Strontium-89|strontium-89	A radioactive compound that is absorbed by the bone. It is used to treat bone pain associated with prostate cancer.
C1568	Dihydrosphingosine	Protein_Kinase_C_Inhibitor	Dihydrosphingosine|2-Amino-1,3-Dihydroxyoctadecane|Kynacyte|L-Threo-Dihydrosphingosine|Safingol|Sphinganine	A saturated derivative of sphingosine. As an inhibitor of protein kinase C (PKC), dihydrosphingosine competitively binds to the regulatory phorbol-binding domain of PKC, a kinase involved in tumorigenesis.  This agent has been shown to act synergistically with other chemotherapeutic agents and may potentiate chemotherapy drug-induced apoptosis in vitro and in vivo. (NCI04)
C1569	Daclizumab	Immunosuppressant|Monoclonal_Antibody	Daclizumab|Anti-Tac|Anti-Tac Humanized Monoclonal Antibody|Anti-Tac Monoclonal Antibody|AntiTac|Dacliximab|Daclizumab (Zenapax, Humanized Anti-Tac, HAT, Humanized Anti-IL-2R)|Humanized Anti-Tac Monoclonal Antibody|MA to TAC(IL-2 Receptor)|Monoclonal Antibody Anti-Tac|Zenapax|daclizumab	A monoclonal antibody that is being studied for treatment of adult T-cell leukemia.  Also called dacliximab.  Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.
C1570	Monoclonal_Antibody_Ch14_18	Monoclonal_Antibody	Monoclonal Antibody Ch14.18|Ch14.18|Ch14.18 Monoclonal Antibody|Chimeric MOAB 14.18 (CH14.18)|MoAb Ch14.18	A chimeric mouse/human monoclonal antibody with potential antineoplastic activity. Monoclonal antibody Ch14.18 binds to the ganglioside GD2 and induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity against GD2-expressing tumor cells.  GD2 is overexpressed in malignant melanoma, neuroblastoma, osteosarcoma, and small cell carcinoma of the lung. (NCI04)
C1571	Flavopiridol	Cyclin-Dependent_Kinase_Inhibitor_Drug|Immunosuppressant	Flavopiridol|(-)-2-(2-Chlorophenyl)-5,7-dihydroxy-8-[(3R,4S)-3-hydroxy-1-methyl-4-piperidinyl]-4H-1-benzopyran-4-one Hydrochloride|4H-1-Benzopyran-4-one, 2-(2-chlorophenyl)-5, 7-dihydroxy-8-(3-hydroxy-1-methyl-4-piperidinyl)-, hydrochloride, (-)-cis-|Alvocidib|Flavopirodol/HMR-1275|flavopiridol	A substance that is being studied as an anticancer drug.  It belongs to the family of drugs called flavanoids.
C1572	Recombinant_Viral_Vaccine	Vaccine	Recombinant Viral Vaccine	A vaccine produced from genetically engineered viral vector by introduction of foreign genetic materials to activate immune response in a host.
C1573	Incomplete_Freunds_Adjuvant	Vaccine_Adjuvant	Incomplete Freund's Adjuvant|Freund's Incomplete Adjuvant|ISA-51|Montanide ISA 51|Montanide ISA-51|incomplete Freund's adjuvant	A drug used in vaccine therapy to stimulate the immune system.
C1574	Alitretinoin	Retinoic_Acid_Agent	9-cis-Retinoic Acid|3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)2-trans-4-trans-6-cis-8-trans-nonatetraenoic Acid|9-Cis-Retinoic Acid|9-Cis-Retinoic Acid (Panretin)|9-cRA|9-cis Retinoic Acid|9-cis retinoic acid|ALITRETINOIN|ALRT1057|Alitretinoin|LGD1057|Panretin|Panretyn|Panrexin|Retinoic acid, 9-cis-|Retinoicacid-9-cis	A drug being studied for cancer prevention.  It belongs to the family of drugs called retinoids.
C1575	Disaccharide_Tripeptide_Glycerol_Dipalmitoyl	Chemo_Immunostimulant_Adjuvant|Miscellaneous_Angiogenesis_Inhibitor	Disaccharide Tripeptide Glycerol Dipalmitoyl|DTP-GDP|ImmTher|Liposomal N-Acetylglucosaminyl-N-Acetyhnuramly-L-Ala-D-isoGlu-L-Ala-gylceroldipalmitoyl|N-Acetylglucosaminyl-N-acetyhnuramyl-L-Ala-isoGlu-L-Ala-glycerol Dipalmitate	A lipophilic disaccharide tripeptide derivative of muramyl dipeptide (MDP).  Exhibiting greater immunomodulatory effects than MDP, disaccharide tripeptide glycerol dipalmitoyl, when encased in liposomes, stimulates macrophage activity and increases serum levels of tumor necrosis factor alpha (TNF alpha), neopterin, interleukin (IL)-1 alpha, IL-1 beta, IL-6, IL-8, and IL-12, thereby activating host immune system antitumor functions. (NCI04)
C1576	Sedoxantrone_Trihydrochloride	Anthrapyrazole_Antibiotic	Sedoxantrone Trihydrochloride|CI 958|CI-958|Ledoxantrone|sedoxantrone trihydrochloride	A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called DNA-intercalating compounds. Also called CI-958.
C1577	Nolatrexed	Folate_Antagonist|Radiosensitizing_Agent|Thymidylate_Synthase_Inhibitor	Nolatrexed|3,4-Dihydro-2-amino-6-methyl-4-oxy-5-(4-pyridylthio)-quinazoline Dihydrochloride|AG337|Nolatrexed Dihydrochloride|Nolatrexed Hydrochloride|Thymitaq|nolatrexed	A water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis.  This agent also exhibits radiosensitizing activity. (NCI04)
C1578	Bispecific_Antibody_520C9XH22	Bispecific_Antibody	Bispecific Antibody 520C9XH22|520C9x22 Bispecific Antibody|520C9xH22 Antibody, Bispecific|520C9xH22 Bispecific Antibody|Antibody, Bispecific 520C9xH22|Bispecific Antibody 520C9 x H22|Bispecific Antibody 520C9x22|Bispecific Antibody MDX-H210|Bispecific Antibody MDXH210|BsAb 520C9x22|BsAb 520C9xH22|MDX-210|MDX-H210	A partially humanized bispecific antibody containing Fab fragments of a monoclonal antibody (520C9) targeting HER2/neu-expressing tumor cells and a monoclonal antibody (H22) targeting Fc gamma RI (CD64) receptor-expressing effector cells.
C1579	Eflornithine_Hydrochloride	Eflornithine	Eflornithine Hydrochloride|2-(Difluoromethyl)-dl-ornithine Hydrochloride, Monohydrate|2-Difluoromethyl-dl-ornithine, Monohydrochloride, Monohydrate|EFLORNITHINE HYDROCHLORIDE|Eflornithine hydrochloride|Eflornithine.HCl|Ornidyl|Vaniqua|alpha-Difluoromethylornithine hydrochloride	The hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity.  Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. (NCI04)
C1580	Anti-DNA_Antibody	Pathologic_Ab-Ig_Protein	Anti-DNA Antibody	One of a number of antinuclear autoantibodies.  Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
C1581	Benzydamine_Hydrochloride	Nonsteroidal_Antiinflammatory_Drug	Benzydamine Hydrochloride|Difflam|Tantum	An indazole non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, and anti-edema properties.  Unlike other NSAIDs, benzydamine hydrochloride does not inhibit cyclooxygenases (COX) but stabilizes membranes, resulting in local anesthesia; inhibits the production of pro-inflammatory cytokines; inhibits the generation of reactive oxygen species by neutrophils; inhibits leukocyte aggregation and adhesion; and exhibits antimicrobial properties. (NCI04)
C1582	Carubicin_Hydrochloride	Carubicin	Carubicin Hydrochloride|Carubicin hydrochloride	Hydrochloride salt of the anthracycline antineoplastic antibiotic carubicin.  Carubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)
C1583	Daunomycin	Anthracycline_Antibiotic	Daunorubicin Hydrochloride|(8S-cis)-8-Acetyl-10-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione|5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, (8S-cis)-, hydrochloride|5,12-Naphthacenedione, 8-acetyl-10-[(3-amino-2,3,6-trideoxy-.alpha.-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-, hydrochloride, (8S-cis)-(9CI)|CERUBIDINE|Cerubidin|Cerubidine|Cloridrato de Daunorubicina|DAUNOMYCIN|DAUNORUBICIN HYDROCHLORIDE|DNR|Dauno-Rubidomycine|Daunoblastin|Daunoblastina|Daunoblastine|Daunomycin|Daunomycin Hydrochloride|Daunomycin hydrochloride|Daunomycin, hydrochloride|Daunorrubicina|Daunorubicin|Daunorubicin hydrochloride|Daunorubicin.HCl|Daunorubicini Hydrochloridum|FI-6339|L-lyxo-Hexopyranoside, 3.beta.-acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-10-metldioxo-1a-naphthacenyl 3-amino-2,3,6-trideoxy-,.alpha.-,hydrochloride|Leukaemomycin C|Ondena|RP-13057|RUBOMYCIN C|Rubidomycin|Rubidomycin Hydrochloride|Rubilem|Rubomycin C|daunorubicin	An anthracycline antineoplastic antibiotic isolated from the bacterium Streptomyces coeruleorubidus.  Daunomycin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. (NCI04)
C1584	Loperamide_Hydrochloride	Loperamide	Loperamide Hydrochloride|Imodium AD|LOPERAMIDE HYDROCHLORIDE|loperamide hydrochloride	An antidiarrheal drug.
C1585	Lubricant	Industrial_Product	Lubricant|lubricants	(LOO-brih-kants) Oily or slippery substances.
C1586	Levofloxacin	Quinolone_Antibiotic	Levofloxacin|LEVOFLOXACIN|Levaquin|Quixin|levofloxacin	A substance used to treat bacterial infections.  It belongs to the family of drugs called quinolone antibiotics.
C1587	Idarubicin_Hydrochloride	Idarubicin	Idarubicin Hydrochloride|IDARUBICIN HYDROCHLORIDE|IMI-30|Idamycin|Idarubicin HCl|Idarubicin hydrochloride|SC-33428|Zavedos	The hydrochloride salt of the anthracycline antineoplastic antibiotic idarubicin.  Idarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation.  Due to its high lipophilicity, idarubicin HCL penetrates cell membranes better than other anthracycline antibiotics. (NCI04)
C1588	Ganciclovir_Sodium	Ganciclovir	Ganciclovir Sodium|BIOLF-62|BW-759|BW-759U|Cymevene|Cytovene|DHPG Sodium|DHPG sodium|Denosine|GANCICLOVIR SODIUM|GCV Sodium|GCV sodium|Ganciclovir sodium|RS-21592	The injectable sodiuim salt form of ganciclovir.  When metabolized, ganciclovirs active metabolite, ganciclovir-5-triphosphate (ganciclovir-TP), appears to inhibit viral DNA synthesis by competitive inhibition of viral DNA polymerases and incorporation into viral DNA, resulting in eventual termination of viral DNA elongation. (NCI)
C1589	Reverse_Transcriptase_Inhibitor	Antiviral_Agent|Enzyme_Inhibitor	Reverse Transcriptase Inhibitor
C1590	Antineoplastic_Alkylating_Agent	Alkylating_Agent|DNA_Crosslinking_Agent	Antineoplastic Alkylating Agent|Chemotherapy Alkylating Agents|Chemotherapy Alkylators	Antineoplastic agents that replace hydrogen atom(s) in nucleophilic moieties with alky radical(s), hindering proper function.  Alkylating agents exhibit cytotoxic effects through the alkylation of DNA, resulting in strand cross-linking, ultimately inhibiting DNA replication and cancer cell growth.
C1591	Therapeutic_Beta_Chemokine	Therapeutic_Chemokine	Recombinant Beta Chemokine|C-C Chemokines|CC Chemokines|CC beta Chemokine	Formulated therapeutic analogs of one of a number of endogenous chemotactic polypeptide cytokines.  Beta chemokine is synthesized and released by macrophages, endothelial cells, keratinocytes, fibroblasts, and smooth muscle cells in response to infection or tissue damage, recruiting circulating macrophages to sites of production.  This agent may regulate tumor growth by modulating tumor-associated angiogenesis and metastasis and may either promote or inhibit tumor growth. (NCI04)
C1592	Therapeutic_Alpha_Chemokine	Therapeutic_Chemokine	Recombinant Alpha Chemokine|Alpha Chemokines|C-X-C Chemokines|CXC Chemokines|CXC alpha Chemokine	One of a number of chemotactic cytokines. Alpha chemokines are small polypeptides released by macrophages, endothelial cells, keratinocytes, fibroblasts, and smooth muscle cells in the presence of infection or physical tissue damage.  In a therapeutic setting, these agents may act as chemoattractants to recruit neutrophils and T cells from the blood to sites of infection or damage and may either promote or inhibit tumor growth by modulating tumor-associated angiogenesis and metastasis. Also known as CXC chemokines. (NCI04)
C1593	Therapeutic_Chemokine	Therapeutic_Cytokine	Recombinant Chemokine|Chemokines	Formulated therapeutic analogs of one of a number of endogenous small polypeptide cytokines with potential antineoplastic activity. Synthesized by macrophages, endothelial cells, keratinocytes, fibroblasts, and smooth muscle cells, chemokines are released in the presence of infection or physical tissue damage, and act as chemoattractants to recruit macrophages, neutrophils, and T cells from the blood to sites of infection or damage.  These agents may regulate tumor growth by modulating tumor-associated angiogenesis and metastasis and can either promote or retard tumor growth. (NCI04)
C1594	Anthracycline_Antibiotic	Antineoplastic_Antibiotic|DNA_Minor_Groove_Binding_Agent|Topoisomerase-II_Inhibitor	Anthracycline Antibiotic|Anthracyclines|Chemotherapy, Cancer, Anthracyclines|anthracycline	A member of a family of anticancer drugs that are also antibiotics.
C1595	Tetracycline_Antibiotic	Antibiotic|Protein_Synthesis_Inhibitor	Tetracycline Antibiotic|Tetracycline Antibiotics|Tetracyclines	Any of a group of broad spectrum naphthacene antibiotics isolated from various species of Streptomyces or produced semisynthetically. In bacteria, tetracycline antibiotics block binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. (NCI05)
C1596	ZD0101	Miscellaneous_Angiogenesis_Inhibitor	ZD0101|CM 101|CM-101|ZD 0101	An antiangiogenic polysaccharide toxin derived from group B streptococcus.
C1597	Gusperimus_Trihydrochloride	Retired_Concepts	Gusperimus Trihydrochloride
C1598	Gusperimus	Immunosuppressant	Gusperimus|(+-)-15-Deoxyspergualin|1-Amino-19-guanidino-11-hydroxy-4,9,12-triazanonadecane-10,13-dione|15-Deoxyspergualin|15-Deoxyspergualin Hydrochloride|7-{(Aminoiminomethyl)amino]-N-[2-[[4-[(3-aminopropyl)amino]butyl]amnio]-1-hydroxy-2-oxoethyl]heptanamide|BMS-181173|BMY-42215-1|DSG|Deoxyspergualin|Deoxyspergualin Hydrochloride|Gusperimus Trihydrochloride|N-[[[4-[(3-Aminopropyl)amino]-butyl]carbamoyl]hydroxymethyl]-7-guanidinoheptanamide|NKT-01|Spanidin	A derivative of the antitumor antibiotic spergualin with immunosuppressant activity.  Gusperimus inhibits the interleukin-2-stimulated maturation of T cells to the S and G2/M phases and the polarization of the T cells into IFN-gamma-secreting Th1 effector T cells, resulting in the inhibition of growth of activated naive CD4 T cells; this agent may suppress growth of certain T-cell leukemia cell lines. (NCI04)
C1599	Bicalutamide	Anti-Androgen	Bicalutamide|(+/-)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide|4'-Cyano-alpha,alpha,alpha-trifuloro-3-[(p-fluorophenyl)sulfonyl]-2-methyl-m-lactotoluidide|4-Cyano-3-trifluoromethyl-N-(3-p-fluorophenylsulfonyl-2-hydroxy-2-methylpropionyl)aniline|BICALUTAMIDE|Casodex|Cosudex|ICI 176,334|ICI 176334|N-[4-Cyano-3-(trifluoromethyl)phenyl]3-3[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-propanamide|bicalutamide	A synthetic, nonsteroidal antiandrogen.  Bicalutamide competitively binds to cytosolic androgen receptors in target tissues, thereby inhibiting the receptor binding of androgens. This agent does not bind to most mutated forms of androgen receptors. (NCI04)
C1600	Cidofovir	Nucleic_Acid_Synthesis_Inhibitor	Cidofovir|1(3-hydroxy-2-phosphonomethoxypropyl) Cytosine|CDV|CIDOFOVIR|Vistide|cidofovir	A drug used to treat infection caused by viruses.
C1601	Vorozole	Non-Steroidal_Aromatase_Inhibitor	Vorozole|(+)-6-((4-Chlorophenyl)-1H-1,2,4-triazol-1-ylmethyl)-1-methyl-1H-benzotriazole|(+)-Vorozole|R 83 842|R83842|Rivizor|vorozole	A hormone therapy drug used to decrease the production of estrogen.
C1602	Saquinavir_Mesylate	Protease_Inhibitor	Saquinavir Mesylate|Invirase|SAQUINAVIR MESYLATE|saquinavir mesylate	A drug that belongs to the family of drugs called protease inhibitors. It interferes with the ability of a virus to make copies of itself.
C1603	Tallimustine	Nitrogen_Mustard_Compound	Tallimustine|FCE 24517|PNU-152241	N-deformyl-N-(4-N-N,N-bis(2-choroethylamino)benzoyl)distamycin, a nitrogen mustard compound with alkylating antineoplastic activity.
C1604	DC-Chol_Liposome	Drug_Vehicle	DC-Cholesterol Liposome|DC-Chol Liposomes|Dimethylaminoethane-carbamoyl-cholesterol Liposomes	A cationic cholesterol derivative mixed with dimethylaminoethane-carbamoyl and sonicated to form small unilamellar vesicles that can complex with DNA, DNA/protein complexes and other drug complexes and mediates the delivery into the cytosol from the endosome compartment. (NCI)
C1605	Tecogalan_Sodium	Angiogenesis_Activator_Inhibitor	Tecogalan Sodium|DS-4152|SP-PG|Sulfated Polysaccharide Tecogalan DS-4152	A sulfated polysaccharide isolated from various Arthrobacter bacterial species.  Possessing potential antiangiogenic and antineoplastic properties, tecogalan binds to basic fibroblast growth factor (bFGF), thereby preventing bFGF from binding to its receptors.  Disruption of this receptor binding results in the inhibition of bFGF-stimulated endothelial cell growth, proliferation, and migration. (NCI04)
C1606	Lobradimil	Miscellaneous_Adjuvant	Lobradimil|Cereport|DRG-0182|L-Prolinamide, L-Arginyl-L-prolyl-trans-4- hydroxy-L-prolyl-3-(2- thienyl)-L-alanylglycl -L-seryl-N-(2-((4-((aminoiminomethyl)amino)-1- -carboxybutyl)amino)-1-((4-methoxyphenyl)methyl)ethyl)-, (S-(R*,R*))|L-Prolinamide,L-Arginyl-L-protyl-trans-4-hydroxy-L-prolyl-3-(2-thienyl)-L-alanylglycyl-L-seryl-N-02-004-0(aminoiminomethyl)amino)-1-0(4-methoxyphenyl)methyl)ethyl)-,0S-(R*,R*))|RMP-7	A substance that is being studied for its ability to help other drugs reach the brain.  It belongs to the family of drugs called bradykinin agonists. Also called lobradimil.
C1607	Anastrozole	Non-Steroidal_Aromatase_Inhibitor	Anastrozole|2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile)|ANASTROZOLE|Alpha,alpha,alpha', alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile|Anastrozole (Arimidex)|Arimidex|ICI D1033|ICI-D1033|ZD-1033|anastrozole	A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure.  As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis.  In estrogen-dependent breast cancers, ananstrozole may inhibit tumor growth. (NCI04)
C1608	Therapeutic_Lymphotoxin_Beta	Therapeutic_Tumor_Necrosis_Factor_Family_Protein	Recombinant Lymphotoxin Beta|LT-beta|LTB Protein|Lymphotoxin Beta|TNFC|Tumor Necrosis Factor C	Lymphotoxin is a cytokine that orchestrates lymphoid neogenesis and is present on the surface of activated T-, B-, and LAK cells as a heterotrimer of alpha and beta subunits. It is also secreted as an alpha homotrimer. LT beta glycoprotein is a 33 kD type II membrane protein that anchors LT alpha to the cell surface.
C1609	Ritonavir	Anti-HIV_Agent|Protease_Inhibitor	Ritonavir|Norvir|RITONAVIR|ritonavir	A drug that belongs to the family of drugs called protease inhibitors. It interferes with the ability of a virus to make copies of itself.
C1610	Lurtotecan	Camptothecin_Analogue	Lurtotecan|GG 211|GI147211C|lurtotecan	A semisynthetic analogue of camptothecin with antineoplastic activity.  During the S phase of the cell cycle, lurtotecan selectively stabilizes the topoisomerase I-DNA covalent complexes, thereby inhibiting relegation of topoisomerase I-mediated single-strand DNA breaks ultimately inhibiting DNA replication and triggering apoptosis.  In addition, lurtotecan has enhanced aqueous solubility as compared to camptothecin. (NCI)
C1611	_7-Cyanoquinocarcinol	Anthracycline_Antibiotic	7-Cyanoquinocarcinol|(+)-DX 52-1|DX 52-1|DX-52-1|Quinocarmycin Analog (DX-52-1)	A semisynthetic analogue of the tetracyclic antibiotic quinocarmycin.  7-Cyanoquinocarcinol belongs to the naphthyridinomycin/saframycin class of antitumor antibiotics.  These antibiotics appear to exert their effects through DNA alkylation.  It was tested for possible use in patients with refractory solid malignancies, but was abandoned due to its causing renal and gastrointestinal toxicities in an unpredictable manner. (NCI04)
C1612	Glufosfamide	Nitrogen_Mustard_Compound	Glufosfamide|Beta-D-Glucosyl-Ifosfamide Mustard|D-19575|glc-IPM|glufosfamide	An anticancer drug that belongs to the family of drugs called alkylating agents.
C1613	Antineoplaston_AS2-1	Antineoplaston_Agent	Antineoplaston AS2-1	A 4:1 mixture of phenylacetate and phenylacetylgluatmine, degradation products of the antineoplaston agent A10.  Antineoplaston AS2-1 inhibits the incorporation of L-glutamine into tumor-cell proteins, leading to cell cycle arrest in the G1 phase and inhibition of mitosis.  This agent may also inhibit RAS oncogene expression and activate tumor suppressor gene p53, resulting in cell differentiation and apoptosis. (NCI04)
C1614	KRN5500	Anthracycline_Antibiotic	KRN5500|(6-[4-Deoxy-4-(2E, 4E)-tetradecadienoylglycyl] amino-L-glycero - beta-L-mannoheptopyranosyl] amino-9H-purine)	A semisynthetic derivative of the nucleoside-like antineoplastic antibiotic spicamycin, originally isolated from the bacterium Streptomyces alanosinicus.  KRN 5500 inhibits protein synthesis by interfering with endoplasmic reticulum and Golgi apparatus functions.  This agent also induces cell differentiation and caspase-dependent apoptosis. (NCI04)
C1615	LU_79553	Intercalating_Agent	LU 79553|LU-79553	A bisnaphthalimide that intercalates DNA, causing inhibition of DNA, RNA, and protein synthesis.
C1616	Lavendustin_B	Tyrosine_Kinase_Inhibitor	Lavendustin B	A weak tyrosine kinase inhibitor which has been used as a negative control analogue for Lavendustin A. (NCI)
C1617	BR96-Doxorubicin_Immunoconjugate	Immunoconjugate	BR96-Doxorubicin Immunoconjugate|BMS-182248-01|BR96-DOX|BR96-DOX immunoconjugate|BR96-Doxorubicin Conjugate|SGN-15|cBR96-Doxorubicin Immunoconjugate	An antibody-drug conjugate composed of the chimeric monoclonal antibody BR96 chemically linked to the cytotoxic drug doxorubicin.  The antibody moiety of BMS-182248-1 binds to Lewis Y, a cell surface antigen expressed on many solid tumor types.  Thus, the doxorubicin conjugate is targeted specifically to Lewis Y-expressing tumor cells, where it intercalates with DNA, thereby inhibiting DNA replication and repair, RNA synthesis and protein synthesis. (NCI)
C1618	BAGE_Tumor_Antigen	Tumor_Antigen	BAGE Tumor Antigen|B Melanoma Antigen|BAGE	The BAGE gene family encodes CT antigens, recognized by cytotoxic T-lymphocytes.  BAGE is expressed in normal adult testis and in some melanomas, infiltrating bladder carcinomas, mammary carcinomas, head and neck squamous cell carcinomas, and non-small cell lung carcinomas.  The function of BAGE protein is unknown.  (NCI)
C1619	LMB-7_Immunotoxin	Immunotoxin	LMB-7 Immunotoxin|B3(Fv)-PE38|B3(Fv)-PE38 Immunotoxin|HB21(Fv)PE40|Immunotoxin LMB-7|LMB-7|LMB-7 (Single-Chain Immunotoxin)|LMB-7 immunotoxin	A single chain chimeric protein consisting of a monoclonal antibody fragment attached to a portion of the Pseudomonas exotoxin A. LMB-7 immunotoxin attaches to B3, a Lewis Y-related carbohydrate epitope on some solid tumor cells.  The antibody attaches to the cell and the exotoxin inhibits protein synthesis by inactivating elongation factor 2. (NCI04)
C1620	Rebeccamycin_Analogue	Intercalating_Agent|Miscellaneous_Antineoplastic_Antibiotic|Topoisomerase-I_Inhibitor	Rebeccamycin Analogue|1,11-Dichloro-6-[2-(diethylamino)ethyl]-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione|5H-Indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione, 1,11-dichloro-6-(2-(diethylamino)ethyl)-12,13-dihydro-12-(4-O-methyl-beta-D-glucopyranosyl)-|BMS-181176|BMY-27557-14|Becatecarin|DEAE-Rebeccamycin|Rebeccamycin Analog|Rebeccamycin Analogue, Tartrate Salt|Rebeccamycin analog|XL119	A synthetic diethylaminoethyl analogue of the indolocarbazole glycoside antineoplastic antibiotic rebeccamycin.  The rebeccamycin analogue intercalates into DNA and stabilizes the DNA-topoisomerase I complex, thereby interfering with the topoisomerase I-catalyzed DNA breakage-reunion reaction and initiating DNA cleavage and apoptosis.  (NCI04)
C1621	Ho_166_DOTMP	Radioconjugate	Ho 166 DOTMP|166 Holmium-DOTMP|Holmium Ho 166 DOTMP|holmium Ho 166 DOTMP	A drug containing a radioactive isotope that is used in the diagnosis and treatment of cancer.
C1622	Epothilone_A	Epothilone_Compound	Epothilone A	An extract from the myxobacteria Sorangium cellulosum that promotes tubulin polymerization and microtubule stabilization, thereby inhibiting mitosis. Epothilone A appears to be less potent than Epothilone B. (NCI)
C1623	Epothilone_B	Epothilone_Compound	Epothilone B|(-)-Epothilone B|(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione|EPO906|EPO906 (Epothilone B-Novartis)|epothilone B	A compound isolated from the myxobacterium Sorangium cellulosum.  Similar to paclitaxel, epothilone B induces microtubule polymerization and stabilizes microtubules against depolymerization conditions.  In addition to promoting tubulin polymerization and stabilization of microtubules, this agent is cytotoxic for cells overexpressing P-glycoprotein, a characteristic that distinguishes it from the taxanes.  Epothilone B may cause complete cell-cycle arrest. (NCI04)
C1624	Nelfinavir_Mesylate	Nelfinavir	Nelfinavir Mesylate|NELFINAVIR MESYLATE|Viracept|nelfinavir mesylate	A drug that interferes with the ability of a virus to make copies of itself.
C1625	PD-98059	Mitogen-Activated_Protein_Kinase_Inhibitor	PD-98059|2'-Amino-3'-methoxyflavone|2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one|4H-1-Benzopyran-4-one, 2-(2-amino-3-methoxyphenyl)-|PD 098059|PD 98059	A cell-permeable, selective mitogen-activated protein (MAP) kinase inhibitor which exhibits activity through the inhibition of the phosphorylation and activation of MAP kinase. (NCI)
C1626	LY293111	Lipooxygenase_Inhibitor	LY293111|2-[2-Propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5-hydroxyphenoxy]propoxy]phenoxy]benzoic Acid|2-[3-[3-[(5-Ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-2-propylphenoxy]benzoic Acid	A substance that inhibits Leukotriene b4 receptor and causes anti-proliferation and induces apoptosis. (NCI)
C1627	Lewis_Y_Antigen	Tumor_Antigen	Lewis Y Antigen	A carbohydrate molecule expressed on the surface of solid tumors including lung, intestinal, breast, prostate, pancreatic, esophageal, stomach, colon, rectal or ovarian cancers.
C1628	Polyandrol	Quassinoid_Agent	Polyandrol	A quassinoid phytochemical isolated from Castela polyandra and other plant species with potential antineoplastic activity. (NCI04)
C1629	ZD9331	Folate_Antagonist|Thymidylate_Synthase_Inhibitor	Vamidex|(alphaS)-alpha-[[4-[[(1,4-Dihydro-2,7-dimethyl-4-oxo-6-quinazolinyl)methyl]-2-propynylamino]-2-fluorobenzoyl]amino]-1H-tetrazole-5-butanoic Acid|BCG 9331|Vamydex|ZD9331	An orally available nonpolyglutamated, quinazoline antifolate which selectively inhibits Thymidylate Synthase, inhibiting de novo synthesis of thymidine and causing inhibition of DNA synthesis.
C1630	Therapeutic_Interleukin-14	Therapeutic_Interleukin	Recombinant Interleukin-14|HMW-BCGF|High Molecular Weight-B-Cell Growth Factor|IL-14|Interleukin 14
C1631	Recombinant_Inhibin_A	Recombinant_Inhibins	Recombinant Inhibin A|Inhibin Alpha	A recombinant therapeutic agent which is chemically identical to or similar to an endogenous glycoprotein which inhibits pituitary production of follicle-stimulating hormone (FSH).  Produced and secreted by the testis or ovarian follicle, endogenous inhibin A contributes to the control of gametogenesis, embryonic and fetal development, and hematopoiesis and enhances LH-stimulated androgen secretion by human thecal cells. (NCI04)
C1632	ILX-295501	Diarylsulfonylurea_Compound	ILX-295501|ILX 295501|ILX295501|LY 295501|LY-295501|LY295501|N-(((3,4-Dichlorophenyl)amino)carbonyl)-2,3-dihydro-5-benzofuransulfonamide|N-(5-(2,3-Dihydrobenzofuryl)sulfonyl)-N'-(3,4-dichlorophenyl)urea	A substance that is being studied as an anticancer drug.  It belongs to the family of drugs called diarylsulfonylureas.
C1633	Polyvalent_Melanoma_Vaccine	Melanoma_Vaccine	Polyvalent Melanoma Vaccine|PMCV|Polyvalent Melanoma Cell Vaccine	A cancer vaccine consisting of whole irradiated heterologous melanoma cells which express multiple melanoma-related antigens.  Polyvalent melanoma vaccine may stimulate an antitumoral cytotoxic T-cell immune response in the host, resulting in inhibition of tumor cell proliferation and tumor cell death. (NCI04)
C1634	Cemadotin	Dolastatin_Compound	Cemadotin|Cemadotin Hydrochloride|LU-103793|LU103793	A synthetic dolastatin 15 analogue with potential antineoplastic activity.  Cemadotin suppresses spindle microtubule dynamics by binding to tubulin, thereby blocking mitosis. (NCI04)
C1635	Bexarotene	Retinoic_Acid_Agent	Bexarotene|3-methyl TTNEB|4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl]benzoic Acid|BEXAROTENE|LGD1069|Targretin|bexarotene	A synthetic retinoic acid agent with potential antineoplastic, chemopreventive, teratogenic and embryotoxic properties.  Bexarotene selectively binds to and activates retinoid X receptors (RXRs), thereby inducing changes in gene expression that lead to cell differentiation, decreased cell proliferation, apoptosis of some cancer cell types, and tumor regression. (NCI04)
C1636	Therapeutic_Steroid_Hormone	Therapeutic_Hormone	Therapeutic Steroid Hormone|Steroid Hormone	Synthetically made hormones possessing the steroid ring system; e.g., androgens, estrogens, and adrenocortical hormones.
C1637	Xanthine_Oxidase_Inhibitor	Enzyme_Inhibitor	Xanthine Oxidase Inhibitor	A substance that inhibits xanthine oxidase, a potential source of excess oxygen free-radical production and is involved in the metabolic pathway for uric acid formation. (NCI)
C1638	Carbon-14	Radioisotope	Carbon-14|14 Carbon|C-14	An unstable isotope of carbon created when a neutron collides with a nitrogen atom, causing capture of the neutron and release of the proton converting nitrogen to a carbon with fourteen nucleons (6 protons and 8 neutrons).  Carbon-14 emits beta particles as it decays and reverts back to nitrogen.(NCI)
C1639	Iodine_131	Radioactive_Iodine	Iodine I 131|131-Iodine|I 131|I-131|Iodine 131|Iodotope|Iodotrope	A radioactive isotope of iodine with an atomic mass of 131, a half life of eight days, and potential antineoplastic activity. Selectively accumulating in the thyroid gland, iodine I 131 emits beta and gamma particles, thereby killing thyroid cells and decreasing thyroid hormone production.
C1640	Indium_111	Radioisotope	Indium 111|111 Indium|In-111	A radioisotope with a physical half-life of 2.83 days, used to label agents for diagnosis, disease progression and treatment. (NCI)
C1641	Yttrium_90	Radioisotope	Yttrium 90|Y-90	Radioactive isotope of yttrium.  A beta/gamma-emitter with a half life of 2.7 days.
C1642	Technetium_99m	Radioisotope	Technetium 99m|Tc 99m	One of the radioactive isotopes of technetium, a gamma/beta-emitter with a half life of 6 hours.
C1643	Pneumococcal_Polyvalent_Vaccine	Polyvalent_Vaccine	Pneumococcal Polyvalent Vaccine|Pneumococcal Polysaccharide Vaccine|Pneumovax|Pneumovax 23|Pnu-Imune 23	An active immunizing agent used to prevent infection by the bacterium Streptococcus pneumoniae.  This vaccine contains purified capsular antigens from many types of S. pneumoniae to ensure cross-protection.  In addition to their use in immunoprophylaxis, these antigens are useful in research, in the analysis of other immune responses, and in immunodeficiency studies. (NCI04)
C1644	Corynebacterium_Granulosum	Vaccine_Adjuvant	Corynebacterium Granulosum|Corynebacterium granulosum	A bacterium that may stimulate the immune system to fight cancer.
C1645	Methyl_Ether	Organic_Chemical	Methyl Ether	A colorless volatile poisonous liquid compound used as a solvent, fuel, aerosol, propellant and refrigerant. (NCI)
C1646	Recombinant_Human_Methionyl_Stem_Cell_Factor	Recombinant_Granulocyte_Colony_Stimulating_Factor	Recombinant Human Methionyl Stem Cell Factor|Ancestim|Stemgen|r-metHuSCF|recombinant-methionyl human stem cell factor	A hematopoietic growth factor with activity on mature and immature hematopoietic progenitor cells.(NCI)
C1647	Trastuzumab	Monoclonal_Antibody	Trastuzumab|Anti-ERB-2|Anti-HER2/c-erbB2 Monoclonal Antibody|Anti-c-ERB-2|Anti-c-erbB2 Monoclonal Antibody|Anti-erbB-2|Anti-erbB2 Monoclonal Antibody|Anti-p185-HER2|HER2 Monoclonal Antibody|Herceptin|MoAb HER2|Monoclonal Antibody HER2|Monoclonal Antibody c-erb-2|c-erb-2 Monoclonal Antibody|rhuMAb HER2|trastuzumab	A recombinant humanized monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2). After binding to HER2 on the tumor cell surface, trastuzumab induces an antibody-dependent cell-mediated cytotoxicity against tumor cells that overexpress HER2. HER2 is overexpressed by many adenocarcinomas, particularly breast adenocarcinomas. (NCI04)
C1648	ALVAC-CEA_Vaccine	ALVAC_Vaccine	ALVAC-CEA Vaccine|ALVAC-CEA|ALVAC-CEA vaccine	A cancer vaccine containing a canary pox virus (ALVAC) combined with the human carcinoembryonic antigen (CEA) gene.
C1649	Allovectin-7	Non-Viral_Vector-Gene_Complex	Allovectin-7|HLA-B7/Beta2M DNA Lipid (DMRIE/DOPE) Complex|HLA-B7/Beta2M DNA Lipid Complex|HLA-B7/Beta2M Plasmid DNA/DMRIE/DOPE Lipid Complex|HLA-B7/Beta2M Plasmid DNA/Lipid Complex|HLA-B7/Beta2Microglobulin DNA-Liposome Complex	A substance that is being studied as a gene therapy agent for the treatment of cancer.  It increases the ability of the immune system to recognize cancer cells and kill them.
C1650	Peldesine	Immunosuppressant|Purine_Nucleoside_Phosphorylase_Inhibitor	Peldesine|4H-Pyrrolo(3,2-d)pyrimidin-4-one,1,5-dihydro-2-amino-7-(3-pyridinylmethyl)|9-(3-Pyridinylmethyl)-7H-9-deazaguanine|BCX-34|Peldesina|peldesine	A substance that is being studied for the treatment of cancer.
C1651	Motexafin_Lutetium	Photosensitizing_Agent|Texaphyrin	Motexafin Lutetium|Antrin|Lu tex|Lu-Tex|Lutetium Texaphrin|Lutetium Texaphyrin|Lutetium texaphyrin|Lutex|Lutrin|PCI-0123|lutetium texaphyrin	A pentadentate aromatic metallotexaphyrin with photosensitizing properties. Motexafin lutetium preferentially accumulates in tumor cells due to their increased rates of metabolism and absorbs light, forming an extended high energy conformational state that produces high quantum yields of singlet oxygen, resulting in local cytotoxic effects. (NCI04)
C1652	Marimastat	Matrix_Metalloproteinase_Inhibitor	Marimastat|(2S,3R)-3-(((1S)-2,2-Dimethyl-1-(methylcarbamoxy)propyl)carboyl)-2-hydroxy-5-methylhexanohydroxamic Acid|(2S,3R)-3-{(S)-[2,2-Dimethyl-1-(methylcarbamoyl) propyl]carbamoyl}-2-hydroxy-5-methylhexanohydroxamic acid|BB 2516|BB-2516|Marimastat BB-2516|Marimistat|TA-2516|marimastat	An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors. Marimastat is a matrix metalloproteinase inhibitor.
C1653	Biricodar_Dicitrate	Multidrug_Resistance_Modulator	Biricodar Dicitrate|Biricodar|Incel|Incel VX-710 (biricodar dicitrate); VX-853|VX-710	A drug being studied to make cancer cells less resistant to the effects of chemotherapy.
C1654	Multivitamin	Nutritional_Supplement	Multivitamin|Geritol|Multivitamins|Vitamin Supplements (NOS)	A dietary supplement containing all or most of the vitamins that may not be readily available in the diet. Vitamins may be classified according to their solubility either in lipids (vitamins A, D, E, K, F) or in water (vitamins C, B-complex). Present in minute amounts in various foods, vitamins are essential to maintaining normal metabolism and biochemical functions. (NCI04)
C1655	HMG-CoA_Reductase_Inhibitor	Anti-lipidemic_Agent|Enzyme_Inhibitor	HMG-CoA Reductase Inhibitor|Hydroxymethylglutaryl CoenzymeA Reductase Inhibitors|Statin
C1656	Rhenium_186	Radioisotope	Rhenium 186|Re-186	A radioisotope with an atomic number of 75 and a half life of 90 hours that emits beta particles and gamma rays and is used in cancer treatment and diagnostic imaging technique. (NCI)
C1657	Opiate	Opioid	Opiate	Functionally related to the poppy (Papaver somniferum) alkaloid morphine, natural or synthetic Opiates have widespread effects in the central nervous system, and on smooth muscle, due to activation of specific delta, mu, and kappa opiate receptors (each controlling different brain functions). Opiates include natural ingredients of the poppy and their derivatives - opium, morphine, codeine, and heroin. Morphine preparations are used as analgesic, sedative, or anxiolytic agent, but are also abused as street drugs. (NCI04)
C1658	Warfarin_Sodium	Warfarin	Warfarin Sodium|Coumadin|Marevan|Panwarfin|Prothromadin|Tintorane|WARFARIN SODIUM|Waran|Warfarin (Coumadin)|Warfilone	The sodium salt form of warfarin.  As an anticoagulant, warfarin sodium appears to inhibit the regeneration of vitamin K1 epoxide and so the synthesis of vitamin K dependent clotting factors, which include Factors II, VII, IX and X, and the anticoagulant proteins C and S. This inhibition results in a sequential depression of Factors VII, IX, X and II activities. Vitamin K is an essential cofactor for the post ribosomal synthesis of the vitamin K dependent clotting factors. The vitamin promotes the biosynthesis of gamma-carboxyglutamic acid residues in these proteins which are essential for biological activity. (NCI)
C1659	Melengestrol	Therapeutic_Progestin	Melengestrol|MGA|Melengesterol|Melengestrol Acetate	A progestogen-like compound used as a cattle feed additive for its growth promoting effects and suppression of estrus (heat) in heifers. Critics have claimed that hormones used as growth promotants in cattle may cause breast cancer. (NCI)
C1660	Anti-HIV_Agent	Antiviral_Agent	Anti-HIV Agent|Anti-Human Immunodeficiency Virus Agents
C1661	Nucleic_Acid_Synthesis_Inhibitor	Antiviral_Agent	Nucleic Acid Synthesis Inhibitor|Inhibitors, Nucleic Acid Synthesis
C1662	Indinavir	Anti-HIV_Agent|Protease_Inhibitor	Indinavir Sulfate|IDV|INDINAVIR SULFATE|Indinavir|indinavir	A drug that interferes with the ability of a virus to make copies of itself.
C1663	Antineoplastic_Vaccine	Vaccine	Antineoplastic Vaccine|Cancer Vaccines|Neoplasm Vaccines|Tumor Vaccines|cancer vaccine	A vaccine designed to prevent or treat cancer.
C1664	Therapeutic_Interferon-alpha_Inducible_Protein_10	Therapeutic_Alpha_Chemokine	Recombinant Interferon-alpha Inducible Protein 10|CXCL10|IP 10|Interferon-gamma Inducible Protein 10
C1665	Trapoxin	Histone_Deacetylase_Inhibitor	Trapoxin|Cyclo((S)-gamma-oxo-L-alpha-aminooxiraneoctanoyl-L-phenylalanyl-L-phenylalanyl-D-2-piperidinecarbonyl)|Cyclo((S)-phenylalanyl-(S)-phenylalanyl-(R)-pipecolinyl-(2S,9S)-2-amino-8-oxo-9,10-epoxydecanoyl)|Cyclo(L-phenylalanyl-L-phenylalanyl-D-pipecolinyl-L-2-amino-8-oxo -9,10-epoxy - decanoyl)|Trapoxin A	An epoxide-containing cyclotetrapeptide with antitumor activity.  It is an irreversible inhibitor of histone deacetylase.
C1666	Tyrphostin_A30	Tyrphostin_Compound	Tyrphostin A30|AG 30	A potent protein tyrosine kinase inhibitor that exhibits greater specificity for c-ErbB oncoprotein. (NCI)
C1667	RG_14620	Tyrphostin_Compound	RG 14620|Tyrphostin RG-14620	A non-phenolic tyrphostin-class tyrosine kinase inhibitor that inhibits epidermal growth factor receptor, affecting cell proliferation and tumor growth in vivo. (NCI)
C1668	Therapeutic_Platelet_Derived_Growth_Factor_Beta_Chain	Therapeutic_Platlet-Derived_Growth_Factor	Recombinant Platelet Derived Growth Factor Beta Chain|Becaplermin|Platelet-Derived Growth Factor Beta Chain|Platlet-Derived Growth Factor Beta Chain|Regranex|rhPDGF-BB	The recombinant analog of endogenous beta (B) chain of the cytokine platelet-derived growth factor (PDGF).  Synthesized primarily by megakaryocytes, endogenous PDGF consists of two related peptide chains, PDGF-A and PDGF-B.  PDGF functions as a local autocrine and paracrine growth factor in many cellular processes.  Recombinant PDGF, alone and in combination with other agents, may be useful in promoting bone formation and soft tissue repair. (NCI04)
C1669	Temoporfin	Chemopreventive_Agent|Photosensitizing_Agent	Temoporfin|5,10,15,20-Tetra-(m-hydroxyphenyl)chlorin|Foscan|m-Tetrahydroxyphenyl-chlorin|mTHPC|meta-Tetrahydroxyphenyl Chlorin|meta-Tetrahydroxyphenylchlorin|temoporfin	An anticancer drug that is also used in cancer prevention. It belongs to the family of drugs called photosensitizing agents.
C1670	Ibandronate	Biphosphonate	Ibandronate|Bondronate|Boniva	A synthetic nitrogen-containing bisphosphonate.  Ibandronate inhibits farnesyl pyrophosphate synthase, resulting in a reduction in geranylgeranyl GTPase signaling proteins and apoptosis of osteoclasts. This agent increases bone mineral density, decreases bone remodeling, inhibits osteoclast-mediated bone resorption, and reduces metastases-related and corticosteroid-related bone pain. (NCI04)
C1671	Recombinant_Human_Macrophage_Chemoattractant_Protein-2	Therapeutic_Beta_Chemokine	Recombinant Human Monocyte Chemoattractant Protein-2|CCL8|Human Monocyte Chemoattractant Protein-2|MCP-2
C1672	In_111_Pentetreotide	Radioconjugate	In 111 Pentetreotide|Indium In 111 Pentetreotide|Indium In 111-Pentetreotide|Indium In-111 Pentetreotide|Indium-111 Octreotide DTPA|Indium-111-DTPA-D-Phe-1-octreotide|Indium-In 111 Pentetreotide|Indium-In-111-Pentetreotide|Octreoscan|indium In 111 pentetreotide	An anticancer drug belonging to a family of drugs called radiopharmaceuticals.
C1673	Sardomozide	Polyamine_Inhibitory_Agent|S-Adenosyl-Methionine_Decarboxylase_Inhibitor	Sardomozide|2-[4-(Aminoiminomethyl)-2,3-dihydro-1H-inden-1-ylidene]hydrazinecarboximidamide|Amidinoindan-1-one.2'-amidinohydrazone|CGP 48664|CGP-48664|SAM 486A	An anticancer drug that may inhibit the growth of some tumors.
C1674	Therapeutic_Fibroblast_Growth_Factor-2	Therapeutic_Fibroblast_Growth_Factor	Recombinant Fibroblast Growth Factor-2|Basic Fibroblast Growth Factor|FGF2|Fibroblast Growth Factor 2|HBGF-2|Prostatropin|bFGF	A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 2 (FGF-2).  Reflecting its endogenous role, therapeutic FGF-2 exhibits a wide spectrum of biological activities, including the promotion of growth and differentiation in target cells, the regulation of hormone secretion, and the promotion of angiogenesis.  This agent's mitogenic effects on fibroblasts and endothelial cells indicates a potential role in therapeutic angiogenesis and wound healing.  In addition, therapeutic FGF-2 may stimulate neurogenesis and protect neurons against degeneration; FGF-2 supplementation via gene transfer may reduce neuronal degeneration in experimental animal models. (NCI04)
C1675	Tyrphostin_B46	Tyrphostin_Compound	Tyrphostin B46|AG 555	A potent inhibitor of epidermal growth factor receptor kinase autophosphorylation. (NCI)
C1676	Curacin_B	Curacin_Compound	Curacin B	The B isomer of Curacin compound.  Cruacin B inhibits tubulin polymerization, thereby inhibiting mitosis and cell proliferation. (NCI)
C1677	Curacin_C	Curacin_Compound	Curacin C	The C isomer of Curacin compound.  Cruacin C inhibits tubulin polymerization, thereby inhibiting mitosis and cell proliferation. (NCI)
C1678	Curacin_A	Curacin_Compound	Curacin A	The A isomer of Curacin compound.  Cruacin A inhibits tubulin polymerization, thereby inhibiting mitosis and cell proliferation. (NCI)
C1679	Exatecan_Mesylate	Camptothecin_Analogue	Exatecan Mesylate|DX-8951f|Exatecan|exatecan mesylate	A semisynthetic, water-soluble derivative of camptothecin with antineoplastic activity. Exatecan mesylate inhibits topoisomerase I activity by stabilizing the cleavable complex between topoisomerase I and DNA and inhibiting religation of DNA breaks, thereby inhibiting DNA replication and triggering apoptotic cell death. This agent does not require enzymatic activation and exhibits greater potency than camptothecin and other camptothecin analogues. (NCI04)
C1680	Therapeutic_Interleukin-18	Therapeutic_Interleukin	Recombinant Interleukin-18|IFN-Gamma-Inducing Factor|IL-18|Interferon-Gamma-Inducing Factor|Interleukin-18	A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin-18 (IL-18). Produced primarily by macrophages, IL-18 induces the production of interferon-gamma (IFN-gamma), and enhances the activity of natural killer (NK) and cytotoxic T lymphocytes (CTL).  As a potential immunotherapeutic agent, IL-18 displays antitumor effects in vitro and in animal models. (NCI04)
C1681	Alemtuzumab	Monoclonal_Antibody	Alemtuzumab|Alemtuzumab (Campath-1H)|Campath|Campath-1H|MabCampath|MoAb CD52|Monoclonal Antibody CD52|Monoclonal Antibody Campath-1H|alemtuzumab	A monoclonal antibody used to treat leukemia. Monoclonal antibodies are made in the laboratory. They can find cancer cells and bind to them.  Also called Campath-1H.
C1682	L-744_832	Farnesyl_Transferase_Inhibitor	L-744,832	A farnesyl transferase inhibitors.
C1683	Tyrphostin_A47	Tyrphostin_Compound	Tyrphostin A47|AG 213|RG 50864	A member of the tyrphostin family of tyrosine kinase inhibitors that inhibits epidermal growth factor receptor, capacitative calcium ion entry into cells, blocks HT-29 colon cancer cell proliferation and induces non-apoptotic cell death. (NCI)
C1684	Therapeutic_Interleukin-17	Therapeutic_Interleukin	Recombinant Interleukin-17|CTLA-8 (Therapeutic)|IL-17|Interleukin-17
C1685	Therapeutic_TNF-Related_Apoptosis-Inducing_Ligand	Therapeutic_Tumor_Necrosis_Factor_Family_Protein	Recombinant TNF-Related Apoptosis-Inducing Ligand|APO2L/TRAIL|Apo2L|TNF-Related Apoptosis-Inducing Ligand|TRAIL	TNF-related apoptosis-inducing ligand (TRAIL) is a homotrimeric type II membrane protein that rapidly induces oligomerization of receptor intracellular death domains and apoptosis in a variety of tumor cells. TRAIL mRNA is up regulated in response to IFNA and IFNB.  TRAIL demonstrated antineoplastic activity in vivo without significant toxicity.  (NCI)
C1686	ZD2767	Immunoconjugate|Mustard_Prodrug	ZD2767|N-[[4-[Bis(2-iodoethyl)amino]phenoxy]carbonyl]-L-glutamic Acid	A phenol mustard glutamate prodrug which induces apoptosis by cross-linking DNA and with potential use in Antibody Directed Enzyme Prodrug Therapy (ADEPT). (NCI)
C1687	Imatinib	Signal_Transduction_Inhibitor|Tyrosine_Kinase_Inhibitor	Imatinib Mesylate|4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide|CGP 57148|CGP57148B|Gleevec|Glivec|IMATINIB MESYLATE|Imatinib|Imatinib mesylate|STI 571|STI-571|STI571|STI571 (Gleevec)|imatinib mesylate	A drug that is being studied for its ability to inhibit the growth of certain cancers. It interferes with a portion of the protein produced by the bcr/abl oncogene.  Also called Gleevec and STI571.
C1688	Tyrphostin_AG_825	Tyrphostin_Compound	Tyrphostin AG 825|AG 825	A member of the tyrphostin family of tyrosine kinase inhibitors, which selectively inhibits HER2. (NCI)
C1689	Aplidine	Angiogenesis_Activator_Inhibitor|Depsipeptide_Antibiotic|Protein_Synthesis_Inhibitor	Aplidine|Aplidin|DDB|Dehydrodemnin B|Dehydrodidemnin B|N-[1-(1,2-Dioxopropyl)-L-prolyl]didemnin A|aplidine	A cyclic depsipeptide isolated from the marine tunicate Aplidium albicans.  Aplidine displays a broad spectrum of antitumor activities, inducing apoptosis by triggering mitochondrial cytochrome c release, initiating the Fas/DC95, JNK pathway and activating caspase 3 activation.  This agent also inhibits elongation factor 1-a, thereby interfering with protein synthesis, and induces G1 arrest and G2 blockade, thereby inhibiting tumor cell growth. (NCI04)
C1690	Sialyl_Tn-KLH_Vaccine	Antineoplastic_Vaccine	Sialyl Tn-KLH Vaccine|STn-KLH Vaccine|Sialyl Tn-KLH|Theratope|Theratope STn-KLH Vaccine|Theratope Vaccine|sialyl Tn-KLH	A vaccine composed of a substance that enhances immunity plus an antigen found on some tumors of the colon, breast, lung, ovary, pancreas, and stomach.
C1691	Ecteinascidin_743	DNA_Minor_Groove_Binding_Agent|Miscellaneous_Alkylating_Agent|Topoisomerase-I_Inhibitor	Ecteinascidin 743|ET 743|Ecteinascidin|Yondelis|ecteinascidin 743	A tetrahydroisoquinoline alkaloid isolated from the marine tunicate Ecteinascidia turbinate.  Ecteinascidin 743 (ET743) exhibits potent tumor cytotoxicity by prolonging the G2-M phase of the cell cycle.  This agent interacts with the transcription-coupled nucleotide excision repair machinery to induce lethal DNA strand breaks. (NCI04)
C1692	Gastrin_Immunotoxin	Antineoplastic_Vaccine	Gastrin Immunotoxin|G17DT|Gastrimmune	A vaccine comprised of a fragment of the gastrointestinal growth factor-17 (G-17) linked to diphtheria toxin to block gastrin and elicit an immune response. (NCI)
C1693	c-RAF_Antisense	Retired_Concepts	c-RAF Antisense|CGP 69846A|ISIS 5132|ISIS-5132|RAF-IK Antisense ODN
C1694	Bruceanol_G	Bruceanol_Agent	Bruceanol G	A natural quassinoid agent extracted from Brucea antidysenterica with potential antineoplastic activity that is cytotoxic to certain cancer cell lines. (NCI04)
C1695	Bruceanol_H	Bruceanol_Agent	Bruceanol H	A quassinoid phytochemical isolated from the plant Brucea antidysenterica with potential antineoplastic activity. (NCI04)
C1696	Oxamflatin	Histone_Deacetylase_Inhibitor	Oxamflatin|(2E)-5-[3-[(Phenylsufonyl) Aminol Phenyl]-pent-2-en-4-ynohydroxamic Acid|(2E)-N-Hydroxy-5-[3-[(phenylsulfonyl)amino]phenyl]-2-penten-4-ynamide	An inhibitor of histone deacetylase.  It is an aromatic sulfonamide hydroxamate initially found in a screen for inhibitors of the tumorigenic phenotype of K-ras-transformed NIH3T3 cells.
C1697	Fungicide	Pesticide	Fungicide	Any substance or physical agent that inhibits development and kills fungus spores and mycelium. In the United States, fungicides are governed by the 1972 federal Environmental Protection and Control Act. They must be registered with the Environmental Protection Agency and must conform to specifications. They must control the disease without injuring the plant and must leave no poisonous residue on edible crops. Antifungal drugs are approved by the FDA. (NCI)
C1698	Phosphorus-32	Radioisotope	Phosphorus-32|Chromic Phosphate P32|P-32|P32|Phosphocol P32|Phosphorus P32|phosphorus-32	A radioactive form of phosphorus used in the treatment of cancer.
C1699	Zoledronate	Biphosphonate	Zoledronate|CGP 42446|CGP42446A|NDC-Zoledronate|ZOL 446|ZOLEDRONIC ACID|Zoledronic Acid|Zometa|[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic Acid|zoledronate	A drug that belongs to the family of drugs called bisphosphonates. It is used to prevent bone fractures and reduce bone pain in people who have cancer that has spread to the bone.
C1700	RPR_109881A	Taxane_Compound	RPR 109881A	A drug that belongs to the family of anticancer drugs called taxanes.
C1701	Vaccinia_CEA_Vaccine	Vaccinia_Vaccine	Vaccinia CEA Vaccine|Vaccinia Carcinoembryonic Antigen Vaccine|Vaccinia-CEA Vaccine|Vaccinia-CEA Vaccine (180KD)|Vaccinia-Carcinoembryonic Antigen Vaccine|rV-CEA (Vaccinia-CEA, TBC-CEA)|vaccinia CEA vaccine	A cancer vaccine containing the carcinoembryonic antigen (CEA) gene.
C1702	Rituximab	Monoclonal_Antibody	Rituximab|C2B8 Monoclonal Antibody|IDEC-102|IDEC-C2B8|IDEC-C2B8 Monoclonal Antibody|MabThera|Monoclonal Antibody IDEC-C2B8|Rituxan|Rituximab (C2B8 Antibody)|rituximab	A recombinant chimeric murine/human antibody directed against the CD20 antigen, a hydrophobic transmembrane protein located on normal pre-B and mature B lymphocytes. Following binding, rituximab triggers a host cytotoxic immune response against CD20-positive cells. (NCI04)
C1703	Tipifarnib	Farnesyl_Transferase_Inhibitor	Tipifarnib|(+)-6-[Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone|R115777|R115777 (Zarnestra)|Zarnestra|tipifarnib	A nonpeptidomimetic quinolinone with potential antineoplastic activity. Tipifarnib binds to and inhibits the enzyme farnesyl protein transferase, an enzyme involved in protein processing (farnesylation) for signal transduction.  By inhibiting the farnesylation of proteins, this agent prevents the activation of Ras oncogenes, inhibits cell growth, induces apoptosis, and inhibits angiogenesis. (NCI04)
C1704	Nelarabine	Purine_Antagonist	Nelarabine|2-Amino, 6-Methoxypurine Arabinoside|2-Amino-6-methoxypurine arabinoside|2-Amino-9-beta-D-arabinofuranosyl-6-methoxy-9H-purine|506U78|Arranon|Compound 506U78|GW506U78	An anticancer drug that belongs to the family of drugs called antimetabolites.
C1705	Tanomastat	Matrix_Metalloproteinase_Inhibitor	Tanomastat|(S)-3-[(4'-Chloro-4-biphenylyl)carbonyl]-2-[(phenylthio)methyl]propionic acid|4-[4-(chlorophenyl)phenyl]-4-oxo-2S-(phenylthiomethyl) butanoic acid|BAY 12-9566|BAY-12-9566	A biphenyl matrix metalloproteinase (MMP) inhibitor with potential antineoplastic activity.  Tanomastat inhibits MMP-2, MMP-3, and MMP-9, thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. (NCI04)
C1706	MEN-10755	Anthracycline_Antibiotic	MEN-10755|BMS-195615|MEN 10755	A disaccharide analogue of the anthracycline antineoplastic antibiotic doxorubicin.  MEN-10755 intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also induces apoptosis through a p53-independent mechanism.  MEN-10755 is less cardiotoxic than doxorubicin. (NCI04)
C1707	Voriconazole	Antifungal_Agent	Voriconazole|VORICONAZOLE|voriconazole	A drug that treats infections caused by fungi.
C1708	Agent	Conceptual_Entities	Agent|AGT	An active power or cause (as principle, substance, physical or biological factor, etc.) that produces a specific effect.
C1709	Particulate	Pollutant	Particulate|Particulates	The generic term used for a type of air pollution. It consists of complex and varying mixtures of particles suspended in the air such as fine solids such as dirt, soil dust, pollens, molds, ashes, and soot; and aerosols that are formed in the atmosphere from gaseous combustion by-products such as volatile organic compounds, sulfur dioxide and nitrogen oxides. Particles of special concern to the protection of lung health are those known as fine particles, less than 2.5 microns in diameter.
C1710	Pentetic_Acid_Calcium	Pentetic_Acid	Pentetic Acid Calcium|Ca-DTPA|Calcium DTPA|Calcium Pentetic Acid|Calcium Trisodium DTPA|Calcium Trisodium Pentetate|Calcium-DTPA|Calcium-pentetic Acid|Ditripentat-Heyl|Pentetate Calcium Trisodium|Trisodium Calcium Diethylenetriaminepentaacetate|pentetic acid calcium	A drug that protects healthy tissues from the toxic effects of anticancer drugs.
C1711	Myeloablative_Agonist	Agonist	Myeloablative Agonist
C1712	Therapeutic_Gamma_Chemokine	Therapeutic_Chemokine	Recombinant Gamma Chemokine|C Chemokines|Gamma-Chemokines	A family of synthetic or recombinant C-type chemokines lacking adjacent cysteine residues and act as chemoattractants for lymphocytes.(NCI)
C1713	Tyrphostin_AG_126	Tyrphostin_Compound	Tyrphostin AG 126|AG 126	A member of the tyrphostin family of tyrosine kinase inhibitors, that actively blocks lipopolysaccharide-induced production of tumor necrosis factor-a and nitric oxide in macrophages. (NCI)
C1714	Therapeutic_Flt3_Ligand	Therapeutic_Colony_Stimulating_Factor	Recombinant Flt3 Ligand|FLT 3 Ligand|FLT3 Ligand|Flt3-Ligand|Flt3L|Mobist|flt3L	A drug that increases the number of immune cells and may stimulate the immune system to kill cancer cells.
C1715	Tyrphostin_AG_1478	Tyrphostin_Compound	Tyrphostin AG 1478|AG 1478	A member of the tyrphostin family of tyrosine kinase inhibitors, that selectively inhibits epidermal growth factor. (NCI)
C1716	Monoclonal_Antibody_HuG1-M195	Monoclonal_Antibody	Monoclonal Antibody HuG1-M195|Hu-M195 monoclonal antibody|HuG1-M195 monoclonal antibody|MoAb HuG1-M195|MoAb HuM195|monoclonal antibody HuM195|monoclonal antibody HuM195 HuG1-M195	A humanized recombinant monoclonal antibody directed against CD33, a cell surface antigen found on myeloid leukemia blasts and early hematopoietic progenitor cells.  Monoclonal antibody HuG1-M195 stimulates antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells expressing CD33, resulting in a decrease in tumor burden. The humanized version of this monoclonal antibody exhibits less immunogenicity and improved binding affinity compared to its murine counterpart. (NCI04)
C1717	Irofulven	Miscellaneous_Alkylating_Agent	Irofulven|(R)-6'-Hydroxy-3'-(hydroxymethyl)-2',4',6'-trimethylspiro(cyclopropane-1,5'(5H)-inden)-7'(6'H)-one|6-Hydroxymethylacylfulvene|6-hydroxymethylacylfulvene|HMAF|Hydroxymethylacylfulvene|Irofulven (MGI-114)|MGI 114|MGI-114|irofulven	A semisynthetic sesquiterpene derivative of illudin S, a natural toxin isolated from the fungus Omphalotus illudens.  Irofulven alkylates DNA and protein macromolecules, forms adducts, and arrests cells in the S-phase of the cell cycle.  This agent requires NADPH-dependent metabolism by alkenal/one oxidoreductase for activity. Irofulven is more active in vitro against tumor cells of epithelial origin and is more resistant to deactivation by p53 loss and MDR1 than other alkylating agents. (NCI04)
C1718	UDP-4	Differentiation_Inducer	UDP-4|2-(3-ethylureido)-6-methylpyridine	An ureido-derivative of pyridine that induces differentiation in neoplastic cells, causing inhibition of cell proliferation. (NCI)
C1719	PEG_Recombinant_Human_Megakaryocyte_Growth_and_Development_Factor	Recombinant_Human_Thrombopoietin	PEG Recombinant Human Megakaryocyte Growth and Development Factor|Megagen|PEG-MGDF|PEG-rHuMGDF|Pegylated Recombinant Human Megakaryocyte Growth and Development Factor|Polyethylene Glycol-Recombinant Human Megakaryocyte Growth and Development Factor|Polyethylene Glycollated Recombinant Human MGDF|Polyethylene Glycosylated Recombinant Human MGDF	A synthetic compound with polyethylene glycol conjugated with recombinant megakaryocyte growth and development factor.  It was used for the normalization of platelet production in HIV-infected persons.
C1720	KRN7000	Immunostimulant	KRN7000	A drug being studied in the treatment of cancer. It is a biological response modifier that belongs to the family of drugs called glycosphingolipids or agelasphins.
C1721	Tyrphostin_AG_957	Tyrphostin_Compound	Tyrphostin AG 957|AG 957	A member of the tyrphostin family of tyrosine kinase inhibitors that selectively inhibits human p210 tyrosine kinase activity. (NCI)
C1722	Oprelvekin	Retired_Concepts	Oprelvekin|Inform|Interleukin-11-Recombinant|Neumega|recombinant human interleukin-11|rhIL-11
C1723	Cetuximab	Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor|Monoclonal_Antibody	Cetuximab|Anti-EGFR Monoclonal Antibody|Anti-Epidermal Growth Factor Receptor Monoclonal Antibody|C225|C225 Monoclonal Antibody|Erbitux|IMC-C225|Immunoglobulin G1, anti-(human epidermal growth factor receptor) (human-mouse monoclonal C225 gamma1-chain), disulfide with human-mouse monoclonal C225 kappa-chain, dimer|MOAB 225 Anti-EGFR (C225; Cetuximab)|MoAb C225|Monoclonal Antibody C225|cetuximab	A monoclonal antibody specific for the epidermal growth factor receptor (EGFR), a tyrosine kinase that triggers cell division.  Cetuximab binds to and inhibits EGFRs, which are overexpressed on the cell surfaces of many types of tumors.  This agent blocks the tumor growth, invasion, and metastasis associated with the overexpression of cell-surface EGFRs. (NCI04)
C1724	Caspofungin_Acetate	Caspofungin	Caspofungin Acetate|Cancidas|caspofungin acetate	A drug used to prevent or treat infections caused by a fungus (a type of microorganism).  It belongs to the family of drugs called antifungal agents.
C1725	SU5402	Tyrosine_Kinase_Inhibitor	SU5402|3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinone|SU 5402	A substance that inhibits the tyrosine kinase activity of the fibroblast growth factor receptor 1 through the signalling pathway. (NCI)
C1726	SU4984	Tyrosine_Kinase_Inhibitor	SU4984|3-(4-(1-formylpiperazin-4-yl)-benzylidenyl)-2-indolinone|SU 4984	A substance that inhibits the tyrosine kinase activity of fibroblast growth factor receptor 1, tyrosine phosphorylation of the PDGF receptor and the insulin receptor. (NCI)
C1727	Perifosine	Alkylphosphocholine_Compound|Protein_Kinase_C_Inhibitor	Perifosine|4-[[Hydroxy(octadecyloxy)phosphinyl]oxy]-1,1-dimethylpiperidinium, Inner Salt|D21266|Octadecyl-(N,N-dimethylpiperidino-4-yl)phosphate|Octadecylphosphopiperidine|perifosine	An anticancer drug that belongs to the family of drugs called alkyl phospholipids.
C1728	Celecoxib	Cyclooxygenase_Inhibitor	Celecoxib|4-(5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide|Benzenesulfonamide, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-|CELECOXIB|Celebrex|SC-58635|YM 177|celecoxib	A drug that reduces pain. Celecoxib belongs to the family of drugs called nonsteroidal anti-inflammatory agents. It is being studied for cancer prevention.
C1729	CT2584_HMS	Miscellaneous_Angiogenesis_Inhibitor|Multidrug_Resistance_Modulator	CT2584 HMS|1-(11-Dodecylamino-10-Hydroxyundecyl)-3,7-Dimethylxanthine|Apra|CT-2584|CT-2584HMS	A drug that may prevent the growth of blood vessels from surrounding tissue into a solid tumor.  It is being studied for its ability to treat cancer.
C1730	_714-X	Miscellaneous_Biologic_Response_Modifier	714-X|Trimethylbicyclonitraminoheptane Chloride	714-X is a product elaborated and marketed by the private Canadian laboratory. Was found to contain nitrogenated camphor-derivative trimethylbicyclonitraminoheptane chloride, mineral salts, ethyl alcohol, and water. It is claimed to cure cancer, multiple sclerosis, fibromyalgia, AIDS and other diseases by improving the body's immune function. Few inconclusive animal studies and no human trials were conducted with the product. There is no scientific evidence that 714-X is effective in treating any type of disease. It has not been proven to be safe or effective for any use. 714-X is banned by FDA for use in the USA. In Canada 714-X is legally available on compassionate grounds only through a licensed physician. (NCI)
C1731	Tyrphostin_AG_1296	Tyrphostin_Compound	Tyrphostin AG 1296|AG 1296	A member of the tyrphostin family of tyrosine kinase inhibitors that selectively inhibits platelet-derived growth factor receptor protein. (NCI)
C1732	G28-5_sFv-PE40	Immunotoxin	G28-5 sFv-PE40	An immunotoxin consisting of an anti-CD40 antibody linked to a 40kD fragment of Pseudomonas exotoxin.
C1733	TAS-103	Topoisomerase-II_Inhibitor|Topoisomerase-I_Inhibitor	TAS-103	A quinoline derivative that inhibits both topoisomerase I and II, causing a cytotoxic effect in cancer cells. (NCI)
C1734	Histamine_Dihydrochloride	Immunostimulant	Histamine Dihydrochloride|2-(1-H-imidazol-4-yl) Ethylamine Dihydrochloride|Histamine dihydrochloride|Maxamine|histamine dihydrochloride	A drug being studied for its ability to enhance the effectiveness of IL-2 in treating acute myeloid leukemia.
C1735	Sodium_Methotrexate	Methotrexate	Sodium Methotrexate|METHOTREXATE SODIUM	The sodium salt of methotrexate, an antimetabolite with antineoplastic and immunomodulating properties.  Methotrxate binds to and inhibits the enzyme dihydrofolate reductase, resulting in inhibition of purine nucleotide and thymidylate synthesis and, subsequently, inhibition of DNA and RNA syntheses.  Methotrexate also exhibits potent immunosuppressant properties. (NCI04)
C1736	Aminobenzoate_Potassium	B_Vitamin	Aminobenzoate Potassium|POTASSIUM P-AMINOBENZOATE|Potaba|Potassium p-Aminobenzoate|Potassium para-Aminobenzoate	A member of the vitamin B complex, involved in several fundamental biological processes. (NCI)
C1737	Organic_Solvents	Organic_Chemical	Organic Solvents	A group of organic liquid compounds that are used for extracting, dissolving, or suspending other water insoluble compounds. (NCI)
C1738	Amphotericin_B_Liposomal	Amphotercin_B	Amphotericin B Liposomal|AmBisome|Liposomal Amphotericin B	Liposome encapsulated macrolide antifungal antibiotic amphotericin B.  Amphotericin B binds to ergosterol altering cell membrane integrity with subsequent cell death.  In addition, the liposomal form has decreased side effects of conventional Amphotericin. (NCI)
C1739	Vincristine_Sulfate	Vincristine	Vincristine Sulfate|Kyocristine|Leurocristine Sulfate|Leurocristine sulfate|Leurocristine, sulfate|Oncovin|VINCRISTINE SULFATE|Vincasar|Vincosid|Vincrex|Vincristine, sulfate	The sulfate salt of a naturally occurring vinca alkaloid. Vincristine binds to and stabilizes tubulin, thereby interrupting tubulin polymerization and preventing the formation of the mitotic spindle and cell division; treated cells are unable to undergo mitosis and are arrested in metaphase. This agent also disrupts macromolecular synthesis. (NCI04)
C1740	Aromatase_Inhibitor	Antiestrogen|Enzyme_Inhibitor	Aromatase Inhibitor|Androstenedione Aromatase Inhibitor|Estrogen Synthase Inhibitor|Estrogen Synthetase Inhibitor	An agent that blocks the function of the enzyme aromatase with antineoplastic activity.  Aromatase inhibitors belong to two classes: Type I steroidal drugs are androgen substrate analogues that bind competitively but irreversibly to the enzyme.  Type II nonsteroidal inhibitors fit into the substrate binding site and bind reversibly to the enzyme.  Present in many tissues, aromatases are heme-containing enzymes that catalyze the adrenal conversion of cholesterol to pregnenolone and the peripheral conversion (aromatization) of androgenic precursors to estrogens. (NCI04)
C1741	Chloride_Ion	Electrolytes|Ions	Chloride Ion|CL|Chloride	A chlorine anion that forms the negatively charged part of certain salts, including sodium and hydrogen chloride salts, and is an essential electrolyte located in all body fluids responsible for maintaining acid/base balance, transmitting nerve impulses and regulating fluid in and out of cells.(NCI)
C1742	Angiogenesis_Inhibitor	Antineoplastic_Agent	Angiogenesis Inhibitor|Angiogenesis Antagonists|Angiogenesis Blockers|Anti-Angiogenic Agents|Antiangiogenesis Agents|angiogenesis inhibitor|antiangiogenic	A substance that may prevent the formation of blood vessels. In anticancer therapy, an angiogenesis inhibitor prevents the growth of blood vessels from surrounding tissue to a solid tumor.
C1743	Chemical_Carcinogen	Carcinogen	Chemical Carcinogen	A chemical compound that is capable of causing cancer in animals and/or in humans after repeated and long duration of exposure.
C1744	Multidrug_Resistance_Modulator	Adjuvant	Multidrug Resistance Modulator|Chemopotentiating Agent|Chemosensitizer|Chemosensitizing Agent|MDR Modulators|Multidrug Resistance Antagonists|Multidrug Resistance Inhibitors|Multidrug Resistance Modifier|Multidrug-Resistance Antagonists|Multidrug-Resistance Chemo Sensitizers|Multidrug-Resistance Inhibitors|chemosensitizer	A drug that makes tumor cells more sensitive to the effects of chemotherapy.
C1745	Flavonoid	Nutrient	Flavonoid|3-Hydroxy-2-phenyl-4H-1-benzopyran-4-one|3-Hydroxyflavone|Flavonol|Flavonols	One of a number of chemical compounds found in certain fruits, vegetables and seeds with antioxidant properties and potential antineoplastic properties. As polyphenolic, soluble plant pigments, flavonoids are usually subdivided into 5 subgroups flavonols, flavones, flavonones, flavan-3-ols, anthocyanidins.  Although not considered essential nutrients, some flavonoids may be beneficial to health by strengthening and protecting blood vessels and connective tissue and acting as anti-inflammatory, antihistaminic, and antiviral agents.  As antioxidants, some flavonoids may protect lipids from oxidative damage or retard the formation of cataracts. (NCI04)
C1746	Peptide_Hormone	Protein_Organized_by_Function	Peptide Hormone	Small proteins that function as hormonal signals, synthesized and secreted by one tissue or organ with physiological effects on other tissues or organs.
C1747	Cruciferous_Vegetable	Fruit_and_Vegetable	Cruciferous Vegetable|Cruciform Vegetables|cruciferous vegetables	A family of vegetables that includes kale, collard greens, broccoli, cauliflower, cabbage, Brussels sprouts, and turnips. These vegetables contain substances that may protect against cancer.
C1748	Topoisomerase_Inhibitor	Enzyme_Inhibitor	Topoisomerase Inhibitor|DNA Topoisomerase Inhibitors|Topoisomerase Inhibitors|topoisomerase inhibitors	A family of anticancer drugs. The topoisomerase enzymes are responsible for the arrangement and rearrangement of DNA in the cell and for cell growth and replication. Inhibiting these enzymes may kill cancer cells or stop their growth.
C1749	Aptamer	Nucleic_Acids	Aptamer	Aptamers are double-stranded DNA or single-stranded RNA oligonucleotide sequences with the capacity to recognize target molecules with high affinity and specificity. Fundamentally distinct from antibodies, aptamers mimic their properties and have emerged as a promising class of molecules in both therapeutic and diagnostic formats. In having small size (8-15 kDa) relative to antibodies (150 kDa), aptamers are candidates for rapid tumor penetration and blood clearance. (NCI)
C1750	Therapeutic_Fibroblast_Growth_Factor_1	Therapeutic_Fibroblast_Growth_Factor	Recombinant Fibroblast Growth Factor 1|Alpha Fibroblast Growth Factor|FGF-1|Fibroblast Growth Factor 1|Heparin Binding Growth Factor|aFGF	A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 1 (FGF-1. Because of the mitogenic and angiogenetic effects of FGF-1 on fibroblasts and endothelial cells, therapeutic FGF-1 has a potential role in wound healing; because FGF-1 has been shown to induce neurogenesis, therapeutic FGF-1 may have a role in nerve regeneration. (NCI04)
C1751	Pollutant	Industrial_Product	Pollutant	Any chemical compound, biological object, physical factor in a concentration or amount that adversely alters the physical, chemical, or biological properties of the environment. The term includes pathogens, toxic metals, carcinogens, oxygen-demanding materials, radiation, natural substances, synthetic industrial chemicals, biocides and all other harmful substances and factors. (NCI)
C1752	Peptide_Vaccine	Vaccine	Peptide Vaccine	A vaccine synthesized from a peptide that mimics the antigen located on the surface of a patient's own tumor cells and elicits an immune response against the tumor cells.  T lymphocytes recognize antigens only as peptide fragments that are generated intracellularly and bound to MHC class I or II molecules on the surface of the antigen presenting cells. Helper T cells recognize antigenic peptides that are bound to the MHC class II molecules, whereas CD8 + cytotoxic T cells are bound to the MHC class I molecules. Therefore, small peptides that are present in the extracellular milieu can bind directly to MHC class I or II molecules without undergoing the antigen processing pathway. Chemically synthesized peptides that are potent immunogenic antigens are being pursued as vaccine candidates.
C1753	Blood_Urea	Urea_Nitrogen	Blood Urea|BUN|Blood Urea Nitrogen	The most prevalent of nonprotein nitrogenous compounds circulating in the blood used as an indicator of liver and kidney function.(NCI)
C1754	Recombinant_Interleukin-1-alpha	Therapeutic_Interleukin-1	Recombinant Interleukin-1-alpha|IL-1 Alpha (Dainppon)|IL-1-alfa|interleukin-1-alpha	A recombinant agent which is chemically identical to or similar to the endogenous protein cytokine interleukin-1 (IL-1). The IL-1 precursor is produced by monocytes, activated macrophages, and other cell types; mature IL-1 is generated by proteolytic cleavage by proteases such as IL-1-beta converting enzyme (ICE). This agent enhances T cell proliferation and B cell growth and differentiation and induces the expression of proinflammatory cytokines. (NCI04)
C1755	Pentosan_Polysulfate	Angiogenesis_Activator_Inhibitor|Nonnarcotic_Analgesic|Tyrosine_Kinase_Inhibitor	Pentosan Polysulfate|CB-8061|Xylan Hydrogen Sulfate|Xylan Polysulfate|pentosan polysulfate	A drug used to relieve pain or discomfort associated with chronic inflammation of the bladder. It is also being evaluated for its protective effects on the gastrointestinal tract in people undergoing radiation therapy.
C1756	Toremifene_Citrate	Toremifene	Toremifene Citrate|(Z)-2-[4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamine 2-Hydroxy-1,2,3-propanetricarboxylate (1:1)|2-(p-[(Z)-4-chloro-1,2-diphenyl-1-butenyl]-phenoxy)- N,N-dimethylethylamine citrate (1:1)|Acapodene|FC-1157a|Fareston|GTx-006|TOREMIFENE CITRATE|Toremifene citrate	The citrate salt of a nonsteroidal triphenylethylene antiestrogen.  Chemically related to tamoxifen, toremifene is a selective estrogen receptor modulator (SERM).  This agent binds competitively to estrogen receptors, thereby interfering with estrogen activity.  Toremifene also has intrinsic estrogenic properties, which is manifested depending on the tissue or species. (NCI04)
C1757	Tyrphostin_Compound	Tyrosine_Kinase_Inhibitor	Tyrphostin Compound
C1758	Tritylcysteine	Tubulin_Binding_Agent	Tritylcysteine|3-Tritylthio-L-Alanine|S-Trityl-L-Cysteine|S-Trityl-L-cysteine|Trityl Cysteine	A derivative of cysteine with antimitotic activity and potential antineoplastic activity. (NCI04)
C1759	Benzodepa	Ethylenimine_Compound	Benzodepa	An aziridine alkylating agent that cross-links with DNA, causing inhibition of DNA synthesis. (NCI)
C1760	Meturedepa	Ethylenimine_Compound	Meturedepa	An aziridine alkylating agent that cross-links with DNA, causing inhibition of DNA synthesis. It was studied for use in colon cancer. (NCI)
C1761	Trypan_Red	Dye	Trypan Red	An acid azo dye commonly used as a stain to distinguish viable from non-viable cells. It was previously used to treat trypanosomiasis.
C1762	Raloxifene_Hydrochloride	Raloxifene	Raloxifene Hydrochloride|6-Hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)methanone Hydrochloride|Evista|Keoxifene Hydrochloride|LY-156758|Optruma|RALOXIFENE HYDROCHLORIDE|Raloxifene HCl|Raloxifene hydrochloride|Raloxifene.HCl	The hydrochloride salt form of raloxifene a selective benzothiophene estrogen receptor modulator (SERM).  Raloxifene binds to estrogen receptors (ER) as a mixed estrogen agonist/antagonist; it displays both an ER-alpha-selective partial agonist/antagonist effect and a pure ER-beta-selective antagonist effect.  This agent functions as an estrogen agonist in some tissues (bones, lipid metabolism) and as an estrogen antagonist in others (endometrium and breasts), with the potential for producing some of estrogen's beneficial effects without producing its adverse effects. (NCI)
C1763	Sergiolide	Quassinoid_Agent	Sergiolide|Sergeolide	A quassinoid phytochemical isolated from Cedronia granatensis and other plant species with potential antineoplastic activity. (NCI04)
C1764	Bruceanol_B	Bruceanol_Agent	Bruceanol B|Picras-3-en-21-oic Acid, 13,20-epoxy-1,11,12-trihydroxy-2,16-dioxo-15-((1-oxopentyl)oxy)-, Methyl Ester, (1beta,11beta,12alpha,15beta)-	A quassinoid phytochemical isolated from the plant Brucea antidysenterica with potential antineoplastic activity. (NCI04)
C1765	Bruceanol_A	Bruceanol_Agent	Bruceanol A|Picras-3-en-21-oic Acid, 15-(benzoyloxy)-13,20-epoxy-1,11,12-trihydroxy-2,16-dioxo-, Methyl Ester, (1beta,11beta,12alpha,15beta)-	A quassinoid phytochemical isolated from the plant Brucea antidysenterica with potential antineoplastic activity. (NCI04)
C1766	Interferon_Alfacon-1	Therapeutic_Interferon	Interferon Alfacon-1|Advaferon|CIFN|Consensus Interferon|IFN Alfacon-1|Infergen|Recombinant Consensus Interferon	A man-made consensus type-I interferon.
C1767	Chaparrin	Quassinoid_Agent	Chaparrin	A quassinoid phytochemical isolated from Simaba cedron and other plant species with potential antineoplastic activity.  Chaparrin is a mixture of compounds that includes flavonoids, antioxidants, and nordihydroguaiaretic acid (NDGA).  NDGA is an antioxidant and lipoxygenase inhibitor that promotes cell differentiation, induces G1 phase cell-cycle arrest, and causes apoptosis in certain cancer cell lines. (NCI04)
C1768	Bruceanol_C	Bruceanol_Agent	Bruceanol C|Picras-3-en-21-oic Acid, 15-((4-(acetyloxy)-3,4-dimethyl-1-oxo-2-pentenyl)oxy)-13,20-epoxy-1,11,12-trihydroxy-2,16-dioxo-, Methyl Ester, (1beta,11beta,12alpha,15beta(E))-	A quassinoid phytochemical isolated from the plant Brucea antidysenterica with potential antineoplastic activity. (NCI04)
C1769	Tyrphostin_A23	Tyrphostin_Compound	Tyrphostin A23|AG 18	A broad spectrum protein tyrosine kinase inhibitor that inhibits epidermal growth factor receptor, GTPase activity of transducin, aldosterone secretion in response to Angiotensin II, and suppresses the activation of MAP kinases. (NCI)
C1770	Aminogenistein	Tyrosine_Kinase_Inhibitor	Aminogenistein|4'-Amino-6-hydroxyflavone	A compound that inhibits the Protein-Tyrosine Kinase Activity of p56lck. (NCI)
C1771	Picrasinoside_H	Quassinoid_Agent	Picrasinoside H|Picras-2-en-1-one, 13-(acetyloxy)-16-(beta-D-glucopyranosyloxy)-2-methoxy-11,12-(methylenebis(oxy))-, (11alpha,12beta,16alpha)-	A quassinoid glycoside phytochemical isolated from the plant Picrasma ailanthoides with potential antineoplastic activity. (NCI04)
C1772	Declopramide	Multidrug_Resistance_Modulator|Radiosensitizing_Agent	Declopramide|3-Chloro-procainamide|3-Chloroprocainamide|OXi-104	A third-generation DNA repair inhibitor that modulates multi-drug resistance.
C1773	Ethynyluracil	Dihydropyrimidine_Dehydrogenase_Inhibitor|Pyrimidine_Antagonist	Ethynyluracil|5-Ethynyl-2,4(1H,3H)-pyrimidinedione|5-Ethynyluracil|5-Fluorouracil Enhancer|5-ethynyluracil|776C85|Eniluracil|GW776|GW776 (Eniluracil)|eniluracil|ethynyluracil	An anticancer drug that increases the effectiveness of fluorouracil. Also called eniluracil.
C1774	Isobrucein_B	Quassinoid_Agent	Isobrucein B	A quassinoid phytochemical isolated from the tropical plant Cedronia granatensis with potential antineoplastic and chemopreventive activities. (NCI04)
C1775	Cancell	Unclassified_Chemotherapy_Agent	Cancell|Entelev	Cancell (Entelev or Cantron), is a liquid that has been produced in various forms, principally by two manufacturers, since the late 1930s.  The exact composition of Cancell/Entelev is unknown, but the U.S. Food and Drug Administration (FDA) has listed the components as inositol, nitric acid, sodium sulfite, potassium hydroxide, sulfuric acid, and catechol.  NCI studies determined that the mixture lacked substantial antitumor activity. (from CancerNet)
C1776	CTP-37	Vaccine_Antigen	CTP-37	A synthetic peptide vaccine consisting of the carboxy terminal peptide (CTP) of human beta chorionic gonadotropin (beta-hCG).  Vaccination with CTP-37 stimulates the host immune system to produce antibodies against beta-HCG, leading to a decrease in the proliferation of tumor cells that overexpress beta-HCG. (NCI04)
C1777	AMD3100	Anti-HIV_Agent	AMD3100|1,1'-[1,4-Phenylenebis(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane|AMD 3100|Bis(Tetraazacyclotetradecane) Derivative|LM-3100	A bicyclam with hematopoietic stem cell-mobilizing properties. AMD3100 blocks the binding of stromal cell-derived factor (SDF-1alpha) to the cellular receptor CXCR4, resulting in hematopoietic stem cell (HSC) release from bone marrow and HSC movement into the peripheral circulation. (NCI05)
C1778	Tyrphostin_B42	Tyrphostin_Compound	Tyrphostin B42|2-Cyano-3-(3,4-Dihydroxyphenyl)-N-(Phenylmethyl)-2-Propenamide|AG 490	A member of the tyrphostin family of tyrosine kinase inhibitors that inhibits epidermal growth factor receptor, blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death. Inhibits the constitutive activation of STAT-3 DNA binding and IL-2-induced growth of Mycosis fungoides tumor cells. (NCI)
C1779	Atrasentan	Endothelin-1_Protein_Receptor_Antagonist	Atrasentan|(+)-A 127722|(2R,3R,4S)-4-(1,3-Benzodioxo-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)-3-pyrrolidinecarboxylic Acid|ABT-627|atrasentan	A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called endothelin-1 protein receptor antagonists.
C1780	Tyrphostin_B56	Tyrphostin_Compound	Tyrphostin B56|AG 556	A member of the tyrphostin family of tyrosine kinase inhibitors, that selectively inhibits epidermal growth factor receptor kinase activity. (NCI)
C1781	Tyrphostin_B50	Tyrphostin_Compound	Tyrphostin B50|AG 835	A member of the tyrphostin family of tyrosine kinase inhibitors that inhibits epidermal growth factor receptor and blocks metavanadate-induced respiratory burst in alveolar macrophages. (NCI)
C1782	Omapatrilat	ACE_Inhibitor	Omapatrilat|Vanlev	An antihypertensive agent that exerts its effect by inhibiting angiotensin converting enzyme and neutral endopeptidase.
C1783	Piposulfan	Alkylsulfonate_Compound	Piposulfan|A 20968|A-20968|NSC-47774	An alkyl sulfonate with potential antineoplastic activity.  Piposulfan alkylates DNA, thereby producing DNA interstrand crosslinks and DNA strand breaks and inhibiting DNA replication.  This agent has been shown to exhibit antitumor activity in an animal model of prostate cancer. (NCI04)
C1784	Monoclonal_Antibody_B43_13	Monoclonal_Antibody	Monoclonal Antibody B43.13|B43.13|MoAb B43.13|OvaRex|OvaRex Monoclonal Antibody B43.13	A murine monoclonal antibody that attaches to the tumor-associated antigen CA125. Vaccination with monoclonal antibody B43.13 may stimulate a host cytotoxic immune response against tumor cells that express CA125. (NCI04)
C1785	Tyrphostin_B48	Tyrphostin_Compound	Tyrphostin B48|AG 494	A member of the tyrphostin family of tyrosine kinase inhibitors that inhibits epidermal growth factor receptor. (NCI)
C1786	Cyanovirin-N	Anti-HIV_Agent	Cyanovirin-N	A protein isolated from the cyanobacterium Nostoc ellipsosporum.  Inactivates the human immunodeficiency virus in vitro, apparently at the level of adsorption to the target cell.
C1787	AG_1517	Tyrphostin_Compound	AG 1517	A quinazoline derivative that selectively inhibits EGFR kinase activity and suppresses the growth of psoriatic keratinocytes. (NCI)
C1788	ISIS_3521	Phosphorothioate_Oligonucleotide	ISIS 3521|Affinitac|Affinitak|CGP 64128A|DNA, d(P-thio)(G-T-T-C-T-C-G-C-T-G-G-T-G-A-G-T-T-T-C-A)|DNA, d(P-thio)(GTTCTCGCTGGTGAGTTTCA)|LY900003|Protein Kinase C-Alpha Antisense	A substance that is being studied in the treatment of cancer.
C1789	Infliximab	Monoclonal_Antibody	Infliximab|Avakine|Remicade|cA2|infliximab	A monoclonal antibody that blocks the action of a cytokine called tumor necrosis factor alfa. It is being studied  in the treatment and prevention of weight loss and loss of appetite in patients with advanced cancer.  It belongs to the family of drugs called monoclonal antibodies.
C1790	GEM_132	Mixed-Backbone_Oligonucleotide	GEM 132|Gene Expression Modulator 132	A 20-mer mixed backbone oligonucleotide exhibiting anti-viral activity.  GEM-132 is comprised of a strand of synthetic DNA with a modified RNA at each end (2-O-methylribonucleosides at the two 3- and four 5-terminal nucleotides) which is complementary to the intron-exon boundary of the UL35 and UL37 premRNA transcripts of human cytomegalovirus. (NCI)
C1791	Recombinant_Methionyl_Human_Brain-Derived_Factor	Therapeutic_Brain-Derived_Growth_Factors	Recombinant Methionyl Human Brain-Derived Factor|r-BDNF|r-metHuBDNF	A recombinant form of neurotrophic growth factor that regulates the development and maintenance of motor neurons expressing trk B receptor tyrosine kinase, with potential use in neurodegenerative disorders. (NCI)
C1792	Therapeutic_Secondary_Lymphoid-Tissue_Chemokine	Therapeutic_Beta_Chemokine	Recombinant Secondary Lymphoid-Tissue Chemokine|6ckine|CCL21|Exodus-2|Secondary Lymphoid-Tissue Chemokine|TCA4|ck beta 9	A formulated therapeutic analogue of a member of the endogenous CC chemokines with potential antineoplastic activity. Expressed by various lymphoid tissues and secondary lymphoid-tissue chemokine is chemotactic for B and T lymphocytes and dendritic cells. (NCI04)
C1793	ZD0473	Platinum_Compound	ZD0473|Cis-Amminedichloro (2-Methylpyridine) Platinum	A new generation of platinum based compounds that has extended spectrum anti-cancer activity and is designed to overcome platinum drug resistance. (NCI)
C1794	Capecitabine	Pyrimidine_Antagonist	Capecitabine|5'-Deoxy-5-fluoro-N-[(pentyloxy)carbonyl]-cytidine|CAPECITABINE|Ro 09-1978/000|Xeloda|capecitabine	A fluoropyrimidine carbamate belonging to the class of antineoplastic agents called antimetabolites.  As a prodrug, capecitabine is selectively activated by tumor cells to its cytotoxic moiety, 5-fluorouracil (5-FU); subsequently, 5-FU is metabolized to two active metabolites, 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP) by both tumor cells and normal cells.  FdUMP inhibits DNA synthesis and cell division by reducing normal thymidine production, while FUTP inhibits RNA and protein synthesis by competing with uridine triphosphate for incorporation into the RNA strand. (NCI04)
C1795	Paclitaxel_Polyglutamate	Paclitaxel	Paclitaxel Poliglumex|CT-2103|PG-TXL|Paclitaxel Polyglutamate|Paclitaxel-Polyglutamate Polymer|Poly-L-Glutamic acid-Paclitaxel Conjugate|Polyglutamic Acid Paclitaxel|Xyotax	A protein that can be linked to a chemotherapy drug to deliver the drug directly to the tumor with fewer side effects.  It is being studied as a treatment for cancer.
C1796	Suberoylanilide_Hydroxamic_Acid	Histone_Deacetylase_Inhibitor	Vorinostat|N-Hydroxy-N'-phenyloctanediamide|SAHA|Suberanilohydroxamic Acid|Suberoylanilide Hydroxamic Acid|suberoylanilide hydroxamic acid	A substance that is being studied as an anticancer drug.
C1797	Carboxycinnamic_Acid_Bishydroxamide	Histone_Deacetylase_Inhibitor	Carboxycinnamic Acid Bishydroxamide|N-Hydroxy-3-[3-(hydroxyamino)-3-oxo-1-propenyl]benzamide|m-Carboxycinnamic Acid Bishydroxamic Acid|m-Carboxycinnamic Acid Bishydroxamide	A hybrid polar compound that induces terminal differentiation and/or apoptosis in various transformed cells.  It is an inhibitor of histone deacetylase.
C1798	Neovastat	Angiogenesis_Activator_Inhibitor|Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor	Neovastat|AE-941|AE-941 (Aeterna Shark Cartilage Extract)|GW786034|Neovastat/AE-941	A multifunctional antiangiogenic agent derived from shark cartilage with potential antineoplastic activity.  Neovastat competitively inhibits the binding of pro-angiogenic vascular endothelial growth factor (VEGF) to its cell receptor, thereby inhibiting endothelial cell proliferation.  This agent also inhibits matrix metalloproteinases (MMPs), stimulates tissue plasminogen activator (tPA), and activates caspase-mediated apoptotic pathways in endothelial cells. (NCI04)
C1799	Detox	Chemo_Immunostimulant_Adjuvant	Detox|DETOX Adjuvant|ENHANZYN	A cancer vaccine adjuvant consisting of a combination of the active monophosphoryl lipid A component of lipopolysaccharide (LPS) isolated from the bacterium Salmonella minnesota combined with a residue of the cell wall of the bacterium Mycobacterium phlei.  Detox is a non-specific immunostimulant that may enhance the host immune response to certain cancer vaccines. (NCI04)
C1800	Vitaxin	Endothelial-Specific_Integrin-Survival_Signaling_Inhibitor|Monoclonal_Antibody	Vitaxin|Medi 522|Medi 522 [Vitaxin]|Monoclonal Anti-Alpha V Beta 3 Integrin|Monoclonal Antibody Anti-Avb3 Integrin	A humanized monoclonal IgG1 antibody to alpha(v)beta(3) integrin with potential antineoplastic activity.  Vitaxin blocks the binding of ligands, such as vitronectin, to endothelial cell surface-expressed alpha(v)beta(3) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. (NCI04)
C1801	Urinary_Bladder_Tumor_Antigen	Tumor_Antigen	Urinary Bladder Tumor Antigen|BTA	Bladder tumor associated antigen is a human complement factor H-related protein (hCFHrp), a glycoprotein produced by cancer cells and macrophages but not by normal epithelia. In cell culture, hCFHrp was shown to be produced by several human bladder cancer cell lines, but not by normal epithelial cell lines. By interaction with complement factor C3b, hCFH serves to inhibit the formation of a membrane attack complex, thereby preventing cell lysis. Production of bladder tumor associated antigen may confer a selective growth advantage to cancer cells in vivo by allowing the cells to evade the host immune system. Approved by FDA as a tumor marker for screening test for transitional cell carcinoma.
C1802	Cigarette	Substance_of_Abuse	Cigarette|CIG|Cigarettes	Finely cut tobacco encased in a wrapper of thin paper and rolled for smoking.
C1803	Soy_Protein_Isolate	Endothelial_Cell_Inhibitor|Nutritional_Supplement	Soy Isoflavone|Isolated Soy Protein|Soy Protein|Soy Protein Isolate|Soybean Isoflavones Extract|Soybean Protein|Soybean Protein Isolate	A dietary protein isolated from soybeans that contains isoflavone phytoestrogens.  Soy protein isolate has been shown to reduce tumor incidence and growth in some animal studies, possibly by modulating estrogen metabolism, reducing tumor cell proliferation, and inducing tumor cell apoptosis.  Soy protein isolate may also inhibit endothelial cell proliferation.  Isoflavone phytoestrogens display mild estrogen-like activities which may regulate hormone balance and reduce the risks of breast cancer, heart disease, and osteoporosis. (NCI04)
C1804	Raltitrexed	Folate_Antagonist|Thymidylate_Synthase_Inhibitor	Raltitrexed|D1694|D1694 (Tomudex)|ICI D1694|N-(5-[N-(3,4-Dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino]-2-thenoyl)-L-glutamic Acid|N-[[5-[[(1,4-Dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]methylamino]-2-thienyl]carbonyl]-L-glutamic Acid|Tomudex|ZD1694|raltitrexed	A quinazoline folate analogue with antineoplastic activity.  After transport into cells via the reduced folate carrier, raltitrexed undergoes intracellular polyglutamation and blocks the folate-binding site of thymidylate synthase, thereby inhibiting tetrahydrofolate activity and DNA replication and repair and resulting in cytotoxicity. (NCI04)
C1805	Arzoxifene	Selective_Estrogen_Receptor_Modulator	Arzoxifene|LY353381	A synthetic, aromatic derivative with anti-estrogenic properties.  Similar to the agent raloxifene, arzoxifene binds to and interacts with estrogen receptors as a mixed estrogen agonist/antagonist. This agent exhibits greater bioavailability and higher anti-estrogenic potency in the breast than does raloxifene; it exhibits reduced estrogenicity in the uterus compared with either tamoxifen or raloxifene.  Arzoxifene may have beneficial effects on bone and the cardiovascular system (NCI04)
C1806	Gemtuzumab_Ozogamicin	Anti-CD33_Immunotoxin	Gemtuzumab Ozogamicin|CDP-771|CMA-676|Calicheamicin-Conjugated Humanized Anti-CD33 Monoclonal Antibody|Mylotarg|WAY-CMA-676|gemtuzumab ozogamicin|hP67.6-Calicheamicin	A recombinant, humanized anti-CD33 monoclonal antibody attached to the cytotoxic antitumor antibiotic calicheamicin.  In this conjugate, the antibody binds to and is internalized by tumor cells expressing CD33 antigen (a sialic acid-dependent glycoprotein commonly found on the surface of leukemic blasts), thereby delivering the attached calicheamicin to CD33-expressing tumor cells. Calicheamicin binds to the minor groove of DNA, causing double strand DNA breaks and resulting in inhibition of DNA synthesis. (NCI04)
C1807	Biafine_Cream	Radioprotective_Agent	Biafine Cream|Biafine|Biafine cream	A topical preparation to reduce the risk of, and treat skin reactions to, radiation therapy.
C1808	_90Y-DOTA-Biotin	Radioconjugate	90Y-DOTA-Biotin|90Y-DOTA-biotin	A radioactive substance (yttrium-90) joined by a large chemical link (DOTA) to biotin, a vitamin.
C1809	Samarium_153	Radioisotope	Samarium 153|Sm-153|samarium 153	A radioactive substance used in cancer therapy.
C1810	GEM_231	Mixed-Backbone_Oligonucleotide|Protein_Kinase_A_Inhibitor	GEM 231|GEM231|Gene Expression Modulator 231	A drug that may inhibit the growth of malignant tumors.
C1811	Prinomastat	Matrix_Metalloproteinase_Inhibitor	Prinomastat|(3S)-N-Hydroxy-2,2-dimethyl-4-{{4-(4-piridinyloxy)phenyl}sulfonyl}-3-thiomorpholinecarboxamide|AG3340|Pinomastat|Prinomastat/AG 3340|prinomastat	A synthetic hydroxamic acid derivative with potential antineoplastic activity.  Prinomastat inhibits matrix metalloproteinases (MMPs) (specifically, MMP-2, 9, 13, and 14), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.  As a lipophilic agent, prinomastat crosses the blood-brain barrier. (NCI04)
C1812	Y_90_Ibritumomab_Tiuxetan	Radioimmunoconjugate	Yttrium Y 90 Ibritumomab Tiuxetan|IDEC Y2B8|IDEC-Y2B8 Monoclonal Antibody|IDEC-Y2B8 monoclonal antibody|Ibritumomab (In2B8/Y2B8 Radiolabeling Kit)|Ibritumomab Tiuxetan|In2B8/Y2B8 Radiolabeling Kit (Ibritumomab tiuxetan, Zevalin)|Y 90 Ibritumomab Tiuxetan|Yttrium-90 Ibritumomab Tiuxetan|Zevalin|y2B8|yttrium Y90 ibritumomab tiuxetan	A radioimmunotherapeutic agent consisting of a murine monoclonal anti-CD20 antibody (ibritumomab) linked by the chelator tiuxetan to the radioisotope yttrium-90 (Y 90).  Yttrium Y 90 ibritumomab tiuxetan binds to and specifically delivers beta radiation to CD20-expressing tumor cells, thereby minimizing the systemic effects of radiation.
C1813	Cigar	Tobacco	Cigar	A compact roll of tobacco leaves prepared for smoking. (WEBS84)
C1814	Nutrient	Dietary_Component	Nutrient|nutrient	A chemical compound (such as protein, fat, carbohydrate, vitamins, or minerals) that make up foods.  These compounds are used by the body to function and grow.
C1815	Aromatic_Amines	Aromatic_Compounds	Aromatic Amines|Arylamines	Amine having a univalent organic group (as phenyl) derived from an aromatic hydrocarbon by the removal of one hydrogen atom. (ISV)
C1816	Substance_of_Abuse	Drugs_and_Chemicals_Functional_Classification	Substance of Abuse|Abused Substances	Pharmacological agents that are used for recreational, not medical, purposes and can become habituating or addictive, especially a narcotic agent. (NCI)
C1818	Ursodiol	Chemopreventive_Agent	Ursodiol|(3alpha,5beta,7beta)-3,7-Dihydroxycholan-24-oic acid|Actigall|Deursil|URSO|URSODIOL|Ursodeoxycholic Acid|Ursodeoxycholic acid	A synthetically-derived form of ursodiol, a bile acid produced by the liver and secreted and stored in the gallbladder.  Also produced by the Chinese black bear liver, ursodiol has been used in the treatment of liver disease for centuries.  This agent dissolves or prevents cholesterol gallstones by blocking hepatic cholesterol production and decreasing bile cholesterol.  Ursodiol also reduces the absorption of cholesterol from the intestinal tract.
C1819	Hydrocortisone_Sodium_Succinate	Therapeutic_Hydrocortisone	Hydrocortisone Sodium Succinate|(11beta)-21-(3-Carboxy-1-oxopropyl)-11,17-dihydroxypregn-4-ene-3,20-dione, Monosodium Salt|A-Hydrocort|Buccalsone|Corlan|Cortisol Sodium Succinate|Cortisol sodium succinate|Cortop|Efcortelan|Emergent-EZ|Flebocortid|HYDROCORTISONE SODIUM SUCCINATE|Hidroc Clora|Hycorace|Hydro-Adreson|Hydro-adreson|Hydrocort|Hydrocortisone 21-Sodium Succinate|Hydrocortisone Na Succinate|Hydrocortisone sodium succinate|Kinogen|Nordicort|Nositrol|Sinsurrene|Sodium hydrocortisone succinate|Solu-Cortef|Solu-Glyc	An injectable sodium succinate salt form of hydrocortisone, a synthetic or semisynthetic analog of natural hydrocortisone hormone with primary glucocorticoid and minor mineralocorticoid effects. As a glucocorticoid receptor agonist, hydrocortisone promotes protein catabolism, gluconeogenesis, capillary wall stability, renal excretion of calcium, and suppresses immune and inflammatory responses. (NCI)
C1820	Mitomycin_C	Mitomycin_Antibiotic	Mitomycin C|(1aS,8S,8aR,8bS)]-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione|Ametycine|MITO|MITO-C|MITOMYCIN|MITOMYCIN C|Mito-C|Mito-Medac|Mitocin|Mitocin-C|Mitolem|Mitomycin|Mitomycin-C|Mitomycin-X|Mitomycine C|Mitozytrex|Mutamycin|Mutamycine|NCI-C04706|[1aS-(1a alpha,8beta,8a alpha,8b alpha)]-6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-5-methylazirino[2',3':3,4]pyrrolo[1,2-a]indole-4,7-dione	A methylazirinopyrroloindoledione antineoplastic antibiotic isolated from the bacterium Streptomyces caespitosus and other Streptomyces bacterial species.  Bioreduced mitomycin C generates oxygen radicals, alkylates DNA, and produces interstrand DNA cross-links, thereby inhibiting DNA synthesis.  Preferentially toxic to hypoxic cells, mitomycin C also inhibits RNA and protein synthesis at high concentrations. (NCI04)
C1821	Selective_Estrogen_Receptor_Modulator	Antiestrogen|Chemopreventive_Agent	Selective Estrogen Receptor Modulator|SERM|SERMs|Selective Estrogen Receptor Modulators|selective estrogen receptor modulator	(sel-EK-tiv ESS-tro-jen re-SEP-tor MOD-yew-lay-tor) SERM.  A drug that acts like estrogen on some tissues but blocks the effect of estrogen on other tissues. Tamoxifen and raloxifene are SERMs.
C1822	Therapeutic_Follicle_Stimulating_Hormone	Therapeutic_Gonadotropin	Recombinant Follicle Stimulating Hormone|Fertinex|Follistim|Follitropin|Gonal-F|Metrodin|Therapeutic FSH	A therapeutic glycoprotein hormone synthesized by recombinant DNA technology or purified from biological sources, whose endogenous counterpart follicle stimulating hormone (FSH) stimulates and maintains the normal functions of reproductive system in males and females. (NCI04)
C1823	Interferon_Beta-1A	Therapeutic_Interferon_Beta	Interferon Beta-1A|Avonex|BG9418|Rebif|Recombinant interferon beta-1a	A synthetic version of naturally occuring interferons that have immunomodulatory, antiviral and antiproliferative activities. It may exert antitumor activity by anti-angiogenic and cell differentiation activities. (NCI)
C1824	Suradista	Angiogenesis_Activator_Inhibitor|Distamycin_Antibiotic	Suradista|PNU-145156E	A sulfonated distamycin A derivative exhibiting antiangiogenic activity.  Suradista binds to the heparin and the selenate-binding sites on basic fibroblast growth factor (bFGF), thereby blocking the binding of bFGF to the FGF receptor and bFGF-induced vascularization. (NCI)
C1825	U-0126	Mitogen-Activated_Protein_Kinase_Inhibitor	U-0126|1,4-Diamino-2,3-dicyano-1,4- bis(2-aminophynyltio)butadiene|Bis[amino[(2-aminophenyl)thio]methylene]butanedinitrile	A synthetic organic compound that selectively inhibits the kinase activity of Mitogen-Activated Protein kinase, preventing cytokine and prostaglandin E2 production. (NCI)
C1826	Cryptophycin_52	Tubulin_Binding_Agent	Cryptophycin 52|C-52|Cyclo[2,2-dimethyl-.beta.-alanyl-(2S)-2-hydroxy-4-methylpentanoyl-(2E,5S,6S)-5-hydroxy-6-[(2R,3R)-3-phenyloxiranyl]-2-heptenoyl-3-chloro-O-methyl-D-tyrosyl]|LY 355703	A member of the cryptophycin family of antitumor agents that binds to microtubules, inducing growth arrest and apoptosis in solid tumors. (NCI)
C1827	BBR_3464	Platinum_Compound	BBR 3464	A cationic tri-nuclear platinum complex related to cisplatin.  BBR 3464 binds to and forms DNA crosslinks and platinum-DNA adducts, preventing DNA replication and tumor cell division. (NCI)
C1828	PC-SPES	Antineoplastic_Plant_Product	PC-SPES	A mixture of 8 chinese herbs which are reported to improve immune function.  There is some clinical evidence that it may be useful as a treatment for prostate cancer.
C1829	Lonafarnib	Farnesyl_Transferase_Inhibitor	Lonafarnib|4-[2-[4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide|4-[2-[4-[(11R)-3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl]-1-piperidinyl]-2-oxoethyl]-1-piperidinecarboxamide|SCH 66336|SCH-66336|SCH66336|Sarasar	A synthetic tricyclic derivative of carboxamide with antineoplastic properties.  Lonarfanib binds to and inhibits farnesyl transferase, an enzyme involved in the post-translational modification and activation of Ras proteins.  Ras proteins participate in numerous signalling pathways (proliferation, cytoskeletal organization), and play an important role in oncogenesis.  Mutated ras proteins have been found in a wide range of human cancers. (NCI04)
C1830	Melanoma_Theraccine	Allogenic_Cell_Vaccine	Melanoma Theraccine|Melacine	A synthetic allogeneic cancer vaccine.  Melanoma theraccine typically consists of lysed melanoma cells obtained from several melanoma cell lines combined with an adjuvant (such as DETOX or RIBI).  This agent may be combined with immunomodulatory cytokines such as interferon alpha.  Melanoma theraccine may induce a rise in the level of cytotoxic T-lymphocyte precursors. (NCI04)
C1831	Semaxanib	Angiogenesis_Activator_Inhibitor	Semaxanib|H-Indol-2-one, 3-((3,5-dimethyl-1H-pyrrol-2-yl)methylene)-1,3-dihydro-|SU 5416|SU5416|Semoxind|Sugen 5416	A derivative of quinolone Semaxanib blocks ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2), thereby inhibiting VEGF-stimulated endothelial cell migration and proliferation and decreasing the density of microvessels supplying tumors.  This agent also inhibits the phosphorylation of the stem cell factor receptor tyrosine kinase c-kit, often expressed in acute myelogenous leukemia cells. Semaxanib has been studied for potential antineoplastic properties. (NCI04)
C1832	Rofecoxib	Cyclooxygenase_Inhibitor	Rofecoxib|4-[4'-(Methylsulfonyl)phenyl]-3-phenyl-2(5H)-furanone|MK 966|ROFECOXIB|Vioxx|rofecoxib	A substance used for pain relief that is also being studied for its ability to prevent cancer and to block the growth of new blood vessels to solid tumors.  It belongs to the family of drugs called nonsteroidal anti-inflammatory drugs.
C1833	S-1	Dihydropyrimidine_Dehydrogenase_Inhibitor|Pyrimidine_Antagonist	S-1|BMS 247616|S1	A drug that is being studied for its ability to enhance the effectiveness of fluorouracil and prevent gastrointestinal side effects caused by fluorouracil. It belongs to the family of drugs called antimetabolites.
C1834	Cilengitide	Endothelial-Specific_Integrin-Survival_Signaling_Inhibitor	Cilengitide|EMD 121974|EMD 121974 (Cilengitide)|cyclo(L-arginylglycyl-L-a-aspartyl-D-phenylalanyl-N-methyl-L-valyl)	A cyclic Arg-Gly-Asp peptide with potential antineoplastic activity.  Cilengitide binds to and inhibits the activities of the alpha(v)beta(3) and alpha(v)beta(5) integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. (NCI04)
C1835	T138067	Tubulin_Binding_Agent	T138067|2-Fluoro-1-methoxy-4-(pentafluorophenyl-sulfonamido)benzene, Sodium Salt|2-Fluoro-1-methoxy-4-pentafluorophenylsulfonamidobenzene|T138067 Sodium	A synthetic pentafluorophenylsulfonamide with potential antineoplastic activity. T138067 covalently binds to and selectively modifies the beta 1, beta 2, beta 3, and beta 4 isotypes of beta tubulin at a conserved cysteine residue, resulting in disruption of microtubule polymerization, collapse of the cytoskeleton, an increase in chromosomal ploidy, cell cycle arrest, and tumor cell apoptosis. (NCI04)
C1836	Radicicol_6-Oxime	Radicicol	Radicicol 6-oxime|KF 25706	A macrocyclic antifungal antibiotic, radicicol oxime derivative that binds and selectively depletes heat shock protein 90 (Hsp90) chaperone, a signaling molecule involved in signal transduction that plays a vital role in tumor cells growth. (NCI)
C1837	Paroxetine_Hydrochloride	Antidepressant_Agent|Antiemetic_Agent	Paroxetine Hydrochloride|PAROXETINE HYDROCHLORIDE|Paroxetine HCl|paroxetine hydrochloride	An antidepressant drug.
C1838	Saw_Palmetto_Berry_Extract	Anti-Androgen|Antineoplastic_Plant_Product	Saw Palmetto Berry Extract	An herbal supplement used commonly to alleviate symptoms of benign prostatic hyperplasia.  In vitro studies show that it may also have anti-cancer properties specific for prostate cancer.
C1839	Lepirudin	Anticoagulant_Agent	Lepirudin|LEPIRUDIN|Recombinant Hirudin|Refludan|lepirudin	A drug that inhibits blood clotting.  It is being studied in cancer treatment.
C1840	L-778_123	Farnesyl_Transferase_Inhibitor	L-778,123|4-[[5-[[4-(3-Chlorophenyl)-3-oxo-1-piperazinyl]methyl]-1H-imidazol-1-yl]methyl]benzonitrile Monohydrochloride|L 778,123|L-778123	A benzylimidazole N-arylpiper-azinone CAAX peptidomimetic.  Due to inhibition of both farnesyl protein transferase and geranylgeranyl protein transferase, L-778,123 was developed to inhibit ras activity.  Preclinical trials failed to show ras activity inhibition. (NCI)
C1841	Iodine_I_125	Radioactive_Iodine	Iodine I 125|125-Iodine|I-125|Iodine 125|Iodine I-125	A radioactive isotope of iodine, a nonmetallic element of the halogen group.  With a half-life of 60 days, iodine 125 occurs naturally and can be produced artificially.  This agent has both therapeutic and diagnostic uses, particularly in thyroid disease. (NCI04)
C1842	BL22_Immunotoxin	CD22_Immunotoxin	BL22 Immunotoxin|Anti-CD22 Recombinant Immunotoxin BL22|BL22|BL22 Immunotoxin [RFB4(dsFv) - PE38|BL22 immunotoxin|Immunotoxin BL22|RFB4(dsFv)-PE38 Immunotoxin	A recombinant immunotoxin consisting of the Fv portion of the anti-CD22 antibody RFB4 fused to a fragment of Pseudomonas exotoxin-A with potential antineoplastic activity.  BL22 immunotoxin binds to CD22, an antigen expressed in B-cell malignancies, thereby delivering its toxin directly to tumor cells.  The toxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also blocks translational elongation via binding to elongation factor-2 in eukaryotic cells. (NCI04)
C1843	BMS-184476	Taxane_Compound	BMS-184476|7-O-[(Methylthio)methyl]paclitaxel|beta-(Benzoylamino)-a-hydroxybenzenepropanoic Acid (aR,bS)-(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-4-[(methylthio)methoxy]-5-oxo-7,11-methano-1H|beta-(Benzoylamino)-alpha-hydroxybenzenepropanoic Acid (aR,bS)-(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-4-[(methylthio)methoxy]-5-oxo-7,11-methano-1H	A 7-methylthiomethyl ether derivative of paclitaxel with antineoplastic activity.  BMS-184476 binds to and stabilizes the resulting microtubules, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and apoptosis. (NCI)
C1844	CCI-779	Immunosuppressant|Macrolide_Antibiotic|mTOR_Inhibitor	CCI-779|42-(3-Hydroxy-2-(hydroxymethyl)-2-methylpropanoate)rapamycin|CCI-779 Rapamycin Analog|Cell Cycle Inhibitor 779|Rapamycin Analog|Rapamycin Analog CCI-779	An anticancer drug that inhibits the growth of cancer cells by preventing cell division.
C1845	PEG-Interferon_Alfa-2B	Pegylated_Interferon_Alfa	PEG-Interferon Alfa-2B|PEG-IFN Alfa-2b|PEG-IFN-a 2b|PEG-Intron|PEG-interferon alfa-2b|Peginterferon ALFA-2B (PEG-Intron)|Polyethylene Glycol IFN-A2b|Polyethylene Glycol Interferon Alfa-2b|SCH 54031	A covalent conjugate of recombinant interferon alpha, subtype 2b, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2b protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2b, thereby extending the duration of its therapeutic effects, but may also reduce the interferon-mediated stimulation of an immune response. (NCI04)
C1846	Leridistim	Differentiation_Inducer|Therapeutic_Colony_Stimulating_Factor	Leridistim|MPO|Myelopoietin|SC-70935|leridistim	A recombinant chimeric dual G-CSF and IL-3 receptor agonist.  Leridistim binds with high affinity to both the interleukin-3 (IL-3) and granulocyte colony-stimulating factor (G-CSF) receptors, thereby stimulating the production and maturation of neutrophils, platelets, and lymphocytes after chemotherapy. (NCI04)
C1847	Therapeutic_Transforming_Growth_Factor-Beta_3	Therapeutic_Transforming_Growth_Factor-Beta	Recombinant Transforming Growth Factor-Beta 3|Therapeutic TGF-Beta 3	A recombinant agent, which is chemically identical to or similar to the endogenous cytokine transforming growth factor-beta-3 (TGF-beta-3). TGF-beta-3 modulates cell growth and immune function and may promote or inhibit tumor growth, depending on the tumor cell type; this agent may also suppress host immune system recognition of and/or response to tumor cells. (NCI04)
C1848	Suramin_Sodium	Suramin	Suramin Sodium|309 F|8,8'-(Carbonylbis(imino-3,1-phenylenecarbonylimino(4-methyl-3,1-phenylene)carbonylimino))bis-1,3,5-naphthalenetrisulfonic Acid Hexasodium Salt|Antrypol|Bayer 205|Belganyl|CI-1003|Fourneau 309|Germanin|Metaret|Moranyl|Naganin|Naganinum|Naganol|Naphuride|Sodium Suramin|Sodium suramin|Suramin Hexasodium|Suramin sodium	A polysulphonated naphthylurea with potential antineoplastic activity.  Suramin sodium uncouples G-proteins from their receptors and inhibits reverse transcriptases, topoisomerases, cell surface binding of various growth factors, cellular transport of folate compounds, protein tyrosine phosphatases, and angiogenesis. (NCI04)
C1849	Aminolevulinic_Acid_Hydrochloride	Aminolevulinic_Acid	Aminolevulinic Acid Hydrochloride|.delta.-Aminolevulinic acid hydrochloride|5-Amino-4-oxopentanoic Acid HCl|5-Amino-4-oxopentanoic Acid Hydrochloride|AMINOLEVULINIC ACID HYDROCHLORIDE|Aminolevulinic Acid HCl|Delta-Aminolevulinic Acid HCl|Delta-Aminolevulinic Acid Hydrochloride|Levulan|Levulan Kerastick	The hydrochloride salt form of aminolevulinic acid.  Aminolevulinic acid (ALA) is converted to protoporphyrin IX (PpIX) which is a photosensitizer. When the proper wavelength of light activates protoporphyrin IX, singlet oxygen is produced, resulting in a local cytotoxic effect. (NCI)
C1850	Micafungin	Antifungal_Agent	Micafungin|FK463	An antibiotic/antifungal drug used to treat infection.
C1851	Bortezomib	Proteasome_Inhibitor	Bortezomib|BORTEZOMIB|LDP 341|MLN341|PS-341|PS341|Velcade|[(1R)-3-Methyl-1-[[(2S)-1-oxo-3-phenyl-2-[(pyrazinylcarbonyl)amino]propyl]amino]butyl]boronic Acid|bortezomib	A dipeptide boronic acid analogue with antineoplastic activity.  Bortezomib reversibly inhibits the 26S proteasome, a large protease complex that degrades ubiquinated proteins.  By blocking the targeted proteolysis normally performed by the proteasome, bortezomib disrupts various cell signaling pathways, leading to cell cycle arrest, apoptosis, and inhibition of angiogenesis.  Specifically, the agent inhibits nuclear factor (NF)-kappaB, a protein that is constitutively activated in some cancers, thereby interfering with NF-kappaB-mediated cell survival, tumor growth, and angiogenesis.  In vivo, bortezomib delays tumor growth and enhances the cytotoxic effects of radiation and chemotherapy. (NCI04)
C1852	CHS_828	Unclassified_Chemotherapy_Agent	CHS 828|CHS-828|N-6-(4-Chlorophenoxy)hexyl)-N'-Cyano-N''-4-Pyridylcyanoguanidine	A drug that is being studied as a treatment for solid tumors.
C1853	L-377_202	Doxorubicin	L-377,202|L-377202	A prodrug in which a peptide is covalently conjugated with the anthracycline antineoplastic antibiotic doxorubicin.  This complex is hydrolyzed by the enzyme prostate-specific antigen (PSA), resulting in the formation of doxorubicin and leucine-doxorubicin.  Selective targeting of these drugs to prostate tumor cells occurs because the hydrolyzing PSA enzyme is localized to the prostate gland.  Doxorubicin and leucine-doxorubicin intercalate into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  These agents also produce toxic free-radical intermediates and interact with cell membrane lipids causing lipid peroxidation. (NCI04)
C1854	Pegfilgrastim	Filgrastim	Pegfilgrastim|Filgrastim SD-01|Neulasta|Pegfilgrastim (Neulasta)|SD-01|SD-01 sustained duration G-CSF|filgrastim-SD/01	A long-acting pegylated form of a recombinant therapeutic agent which is chemically identical to or similar to an endogenous human granulocyte colony-stimulating factor (G-CSF). Produced endogenously by monocytes, fibroblasts, and endothelial cells, G-CSF binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Conjugation of the cytokine with a branched polyethylene glycol molecule (pegylation) significantly increases its therapeutic half-life. (NCI04)
C1855	Gefitinib	Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor	Gefitinib|4-(3Chloro-4-flurophenylamine)-7-methoxy-6(3-(4morpholinyl)quinazoline|4-Quinazolinamine, N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-4-morpholin] propoxy]|GEFITINIB|Iressa|ZD 1839|ZD1839|ZD1839 (IRESSA)|gefitinib	A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors. Also called ZD 1839.
C1856	BMS214662	Farnesyl_Transferase_Inhibitor	BMS-214662|FTI BMS 214662	A non-sedating benzodiazepine derivative with antineoplastic activity. BMS-214662 inhibits the enzyme farnesyl protein transferase, resulting in apoptosis of tumor cells. Farnesyl protein transferase modifies several proteins posttranslationally (farnesylation), including Ras, an oncoprotein implicated in the pathogenesis of many human tumors.  BMS-214662 may also reverse the malignant phenotype of H-Ras-transformed cells. This agent has been shown to be active against tumor cells with and without Ras mutations. (NCI05)
C1857	Monoclonal_Antibody_ABX-EGF	Monoclonal_Antibody	Monoclonal Antibody ABX-EGF|ABX-EGF|ABX-EGF Monoclonal Antibody|MoAb ABX-EGF|Panitumumab	A human monoclonal antibody produced in transgenic mice that attaches to the transmembrane epidermal growth factor (EGF) receptor.  Monoclonal antibody ABX-EGF may inhibit autocrine EGF stimulation of tumor cells that express the EGF receptor, thereby inhibiting tumor cell proliferation. (NCI04)
C1858	BMS-247550	Retired_Concepts	BMS-247550|BMS247550|Epothilone-B BMS 247550	A semi-synthetic analog of the natural product epothilone B that stabilizes microtubules and causes cancer cell death. (NCI)
C1859	BMS-188797	Taxane_Compound	BMS-188797	A substance that is being studied as a treatment for cancer.
C1860	Bacterial_Artificial_Chromosome	Cloning_Vector	Bacterial Artificial Chromosome|BAC	Based upon the natural F plasmid of E. coli.  Inserts up to 300 Kb can be cloned and stably maintained as circular molecules.
C1861	Aclacinomycin_B	Aclacinomycin_Antibiotic	Aclacinomycin B|Aclarubicin B|Antibiotic MA 144B1|[1R-(1alpha,2beta,4beta)-4-[[[2"',3"-anhydro]-O-3,6-dideoxy-alpha-L-erythro-hexopyranos-4-ulos-1-yl-(1-4)-O-2,6-dideoxy-alpha-L-lyxo-hexopyranosyl-(1-4)-2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy]-2-ethyl-1,2,3,4,6,11-hexahydro-2,5,7-trihydroxy-6,11-dioxo-1-naphthacenecarboxylic acid methyl ester	An antineoplastic oligosaccharide anthracycline antibiotic isolated from the bacterium Streptomyces galilaeus.  Aclacinomycin B intercalates into DNA and interacts with topoisomerases I and II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)
C1862	Prednisolone_Sodium_Metasulphobenzoate	Prednisolone	Prednisolone Sodium Metasulphobenzoate|Corti-Clyss|Predenema|Predfoam	A poorly adsorbed analog of prednisolone, a synthetic glucocorticoid with anti-inflammatory and immunomodulating properties.  After cell surface receptor attachment and cell entry, prednisolone enters the nucleus where it binds to and activates specific nuclear receptors, resulting in an altered gene expression and inhibition of proinflammatory cytokine production.  This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis in sensitive tumor cells populations. (NCI)
C1863	MS-27-275	Histone_Deacetylase_Inhibitor	MS-27-275|MS 27-275	An inhibitor of histone deacetylase.  It is a benzamide derivative and acts as an antitumor agent through inhibition of deacetylase.
C1864	MS-247	DNA_Minor_Groove_Binding_Agent	MS-247	A synthetic compound that binds to the DNA minor groove and cause anti tumor activity. (NCI)
C1865	Angiozyme	Miscellaneous_Angiogenesis_Inhibitor	Angiozyme|RPI-4610|RPI.4610|RPI4610	A nuclease-stabilized synthetic ribozyme with potential antineoplastic activity.  Angiozyme cleaves the mRNA encoding vascular endothelial growth factor 1 (VEGF-1, or Flt-1), thereby specifically inhibiting VEGF-stimulated angiogenesis, tumor growth, and metastasis. (NCI04)
C1866	GL331	Epipodophyllotoxin_Compound	GL331	An epipodophyllotoxin analogue possessing antineoplastic properties.  GL331 binds to and inhibits topoisomerase II, resulting in the accumulation of single- or double-strand DNA breaks, the inhibition of DNA replication and transcription, and apoptotic cell death. (NCI)
C1867	Orataxel	Taxane_Compound	Orataxel|BAY 59-8862|Bay 59-8862|IDN5109|SB-T-101131	A second-generation taxoid derivative that exhibits activity against multidrug resistant cancer cell lines and other solid tumors. (NCI)
C1868	PTK787	Angiogenesis_Activator_Inhibitor|Tyrosine_Kinase_Inhibitor	Vatalanib|1-Phthalazinamine, N-(4-chlorophenyl)-4-(4-pyridinylmethyl)-, butanedioate (1:1)|1-[4-Chloroanilino]-4-[4-pyridylmethyl]phthalazine Succinate|Butanedioic Acid, Compd. with N-(4-Chlorophenyl)-4-(4-pyridinylmethyl)-1-phthalazinamine (1:1)|CGP-79787|CGP79787D|PTK787|PTK787/ZK 222584|ZK 222584	An orally bioavailable anilinophthalazine with potential antineoplastic activity.  Vatalanib binds to and inhibits the protein kinase domain of vascular endothelial growth factor receptors 1 and 2; both receptor tyrosine kinases are involved in angiogenesis.  This agent also binds to and inhibits related receptor tyrosine kinases, including platelet-derived growth factor (PDGF) receptor, c-Kit, and c-Fms.
C1869	Valdecoxib	Cyclooxygenase_Inhibitor	Valdecoxib|4-(5-Methyl-3-phenyl-4-isoxazolyl)benzenesulfonamide|Bextra|SC 65872|VALDECOXIB|valdecoxib	A non-steroidal anti-inflammatory agent that selectively inhibits cox-2 and causes the inhibition of prostaglandin synthesis. It may exhibit antiproliferative and antiangiogenesis activities. (NCI)
C1870	Oblimersen	Multidrug_Resistance_Modulator|Phosphorothioate_Oligonucleotide	Oblimersen|Anticode G3139|Augmerosen|BCL-2 Antisense Oligodeoxynucleotide G3139|BCL-2 Antisense/G3139|BCL2 Gene Anticode Oligodeoxynucleotide|G3139|G3139 (Genasense)|G3139 Antisense Oligonucleotide|G3139 BCL-2 Antisense|G3139 BCL-2 Antisense Oligodeoxynucleotide|G3139 BCL-2 Antisense Oligonucleotide|Genasense|augmerosen|bcl-2 antisense oligodeoxynucleotide G3139|oblimersen|olbimersen	A drug that may kill cancer cells by blocking the production of a protein that makes cancer cells live longer.
C1871	PKI166	Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor	PKI166|CGP 75166|CGP 75166/PKI166	A pyrrolo-pyrimidine EGFR protein kinase inhibitor.
C1872	Midostaurin	Protein_Kinase_C_Inhibitor	Midostaurin|CGP 41251|CGP41251|N-Benzoylstaurosporine|PKC-412|PKC412	A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called protein kinase C (PKC) inhibitors.
C1873	SR-45023A	Biphosphonate	SR-45023A|1,1-Bisphosphonate Ester|Apomine|SR-45023A (Apomine)|Tetraisopropyl-2-(3,5-di-tert-butyl-4-hydroxyphenyl)ethylidene-1,1-diphosphonate	An anticancer drug that belongs to the family of drugs called bisphosphonates. It affects cancer cell receptors governing cell growth and cell death.
C1874	ERA_923	Selective_Estrogen_Receptor_Modulator	Pipendoxifene|2-(4-Hydroxyphenyl)-3-methyl-1-[4-(2-piperidin-1-ylethoxy)benzyl]-1H-indol-5-ol Hydrochloride|ERA 923|ERA-923	A substance that is being studied as a treatment for cancer.  It belongs to a family of drugs called antiestrogens.
C1875	BMS-275291	Matrix_Metalloproteinase_Inhibitor	BMS-275291|BMS 275291 (MMPI)|D2163|N-((2S)-2-Mercapto-1-oxo-4-(3,4,4-trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-L-leucyl-N,3-dimethyl-L-valinamide	A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called matrix metalloproteinase inhibitors (MMPIs).
C1876	Lurtotecan_Liposome	Lurtotecan	Lurtotecan Liposome|NX211|liposomal lurtotecan|liposome, lurtotecan	A liposome-encapsuled formulation of lurtotecan, a semisynthetic analogue of camptothecin.  During the S phase of the cell cycle, lurtotecan selectively stabilizes the topoisomerase I-DNA covalent complexes, thereby inhibiting relegation of topoisomerase I-mediated single-strand DNA breaks ultimately inhibiting DNA replication and triggering apoptosis. (NCI)
C1877	Karenitecin	Camptothecin_Analogue	Karenitecin|BNP1350|karenitecin	A drug being studied in the treatment of cancer.  It belongs to a family of drugs called topoisomerase inhibitors. It is related to the anticancer drug camptothecin.
C1878	Darbepoetin_Alfa	Recombinant_Erythropoietin	Darbepoetin Alfa|Aranesp|NESP|Nespo|Novel Erythropoiesis Stimulating Protein|darbepoetin alfa	(dar-be-POE-e-tin AL-fa) A substance made in the laboratory that stimulates the bone marrow to produce red blood cells. It belongs to the family of drugs called antianemics.
C1879	MGN3	Immunostimulant	MGN3|Arabinoxylan Compound|Biobran	An arabinoxylane polysaccharide composed of the hemicellulose-Beta extract of rice bran, treated with enzymes from Shiitake mushrooms, that exerts antitumor and antiviral activity by increasing the level of natural killer cells activation. (NCI)
C1880	CI-1033	Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor	CI-1033|CI-1033/PD183805|N-[-4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide|N-[-4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-quinazolinyl]-2-propenamide Dihydrochloride|PD183805	A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called tyrosine kinase inhibitors.
C1881	Motexafin_Gadolinium	Radiosensitizing_Agent|Texaphyrin	Motexafin Gadolinium|Gadolinium Texaphyrin|Gd (III) Texaphryin|Gd-Tex|PCI-0120|Xcytrin|Xcytrin (Gadolinium Texaphyrin)|motexafin gadolinium	A substance that makes tumor cells more sensitive to radiation; it can also enhance tumor images using magnetic resonance imaging (MRI). Motexafin gadolinium belongs to the family of drugs called  metalloporphyrin complexes.  Also called gadolinium texaphyrin.
C1882	NB1011	Enzyme_Catalyzed_Therapeutic_Activation_Agent	NB1011|Thymectacin	A modified nucleotide that interacts with thymidylate synthase (TS), an enzyme important in DNA synthesis and over expressed in most cancer cells. NB1011 enters the cell as a harmless substrate for TS, upon interaction, it is converted into a deadly toxin that kills the tumor cell. (NCI)
C1883	ILX23-7553	Differentiation_Inducer	ILX23-7553|1,25-dihydroxy-16-ene-23-yne-cholecalciferol|Ro23-7553	A Vitamin D3 analog that has the ability to induce differentiation and inhibit the proliferation of tumor cells. (NCI)
C1884	SU6668	Angiogenesis_Activator_Inhibitor	SU6668|SU 6668|Sugen SU6668	A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called angiogenesis inhibitors.  Also called SU006668.
C1885	GEM_92	Mixed-Backbone_Oligonucleotide	GEM 92|Gene Expression Modulator 92	A 25-mer antisense oligodeoxynucleotide phosphorothioate.  GEM-92 is complementary to the gag mRNA of human immunodeficiency virus type 1 (HIV-1), resulting in HIV-1 replication inhibition. (NCI)
C1886	BAY_56-3722	Camptothecin_Analogue	BAY 56-3722|BAY 38-3441	A camptothecin derivative conjugated to a carbohydrate moiety exhibiting antineoplastic properties.  BAY 56-3722 stabilizes the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks and consequently triggering apoptosis.  The glycoconjugate portion of this agent stabilizes the lactone form of camptothecin, thereby increasing the lactone available for uptake by tumor cells. (NCI)
C1887	Epratuzumab	Monoclonal_Antibody	Epratuzumab|Epratuzumab (hLL2)|Humanized Anti-CD22 Monoclonal Antibody IgG1|LymphoCide|epratuzumab|hLL2	A recombinant, humanized monoclonal antibody directed against CD22, a cell surface glycoprotein present on mature B-cells and on many types of malignant B-cells.  After binding to CD22, epratuzumab's predominant antitumor activity appears to be mediated through antibody-dependent cellular cytotoxicity (ADCC).
C1888	NM-3	Angiogenesis_Activator_Inhibitor	NM-3	An orally bioavailable antiangiogenic isocoumarin with potential antineoplastic activity.  NM-3 inhibits vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor, thereby inhibiting endothelial cell proliferation.  This agent also induces apoptosis by a mechanism involving reactive oxygen species. (NCI04)
C1889	Brostallicin	DNA_Minor_Groove_Binding_Agent	Brostallicin|brostallicin	A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called DNA intercalators.
C1890	Adenovirus_Vector	Cloning_Vector	Adenovirus Vector|Adenoviral Vector	One of a number of genetically-engineered adenoviruses designed to insert a gene of interest into a eukaryotic cell where the gene of interest is subsequently expressed.  Unlike most other vectors, adenovirus vectors have the ability to infect post-mitotic cells.  Thus, these agents are especially useful for gene transfer into neuronal cells. (NCI04)
C1891	Anti-Progestin	Hormone_Antagonist	Anti-Progestin|Anti-progesterones	A substance that blocks the activity of a progestin.
C1892	Chemopreventive_Agent	Pharmacologic_Substance	Chemopreventive Agent|Chemopreventive|anticarcinogenic	(AN-tih-KAR-sin-o-JEN-ik) Pertaining to something that prevents or delays the development of cancer.
C1893	Dolastatin_Compound	Miscellaneous_Angiogenesis_Inhibitor|Tubulin_Binding_Agent	Dolastatin Compound|Dolastatins	One of a number of natural peptides originally isolated from the marine mollusk Dolabella auricularia.  Dolastatin compounds interact with tubulin, thereby inhibiting microtubule assembly, and induce tumor cell apoptosis. (NCI04)
C1894	Environmental_Estrogen	Therapeutic_Estrogen	Environmental Estrogen	Environmental Estrogens are a variety of natural and synthetic substances that may mimic natural estrogen hormones.
C1895	Polyhalogenated_Hydrocarbons	Halogenated_Hydrocarbon	Hydrocarbons, Polyhalogenated	Hydrocarbons containing multiple halogen substituents (Br, Cl, Fl, I).
C1896	Monoclonal_Antibody_for_Clinical_Diagnosis	Diagnostic_Reagent	Monoclonal Antibody, for Clinical Diagnosis|MoAb, for Clinical Diagnosis|Moab, Clinical Diagnosis	Monoclonal antibodies used for clinical diagnosis
C1897	Phosphorylated_Peptide	Peptide	Phosphorylated Peptide	Peptides containing phosphoryl group substituents on the R groups of amino acids, principally serine, threonine, and tyrosine.
C1898	Physical_Carcinogens	Carcinogen	Physical Carcinogens	Physical agents, such as radiation, that may have a role in development of cancer.
C1899	Physiology-Regulatory_Factor	Drugs_and_Chemicals_Functional_Classification	Physiology-Regulatory Factor|Physiology-Regulatory Factors	Factors, produced by the body, which regulate some aspect of physiology.
C1900	Pox_Virus_Vectors	Cloning_Vector	Pox Virus Vectors	Cloning vectors derived from vaccinia virus or other pox viruses, eg canarypox.  Usually used for expression of foreign genes in mammalian cells, especially as a component of a vaccine.
C1901	Pteridines_Folic_Acid_Analogs	Heterocyclic_Compound	Pteridines, Folic Acid Analogs	Folic acid analogs containing a pteridine base, a two-ring heterocyclic aromatic compound, and are used to interfere with folic acid.
C1902	Ras_Inhibitor	Signal_Transduction_Inhibitor	Ras Inhibitor	Drugs or vaccines that specifically or preferentially interfere with the action of the ras oncogene.
C1903	Intracellular_Second_Messenger	Signaling_Molecule	Intracellular Second Messenger|Second Messengers of Signal Transduction	Systems in which an intracellular signal is generated in response to an intercellular primary messenger such as a hormone or neurotransmitter. They are intermediate signals in cellular processes such as metabolism, secretion, contraction, phototransduction, and cell growth. Examples of second messenger systems are the adenyl cyclase-cyclic AMP system, the phosphatidylinositol diphosphate-inositol triphosphate system, and the cyclic GMP system.
C1904	Topoisomerase-I_Inhibitor	Topoisomerase_Inhibitor	Topoisomerase-I Inhibitor|Topoisomerase-I Inhibitors	Compounds that inhibit the action of topoisomerase I (see Topoisomerase Inhibitors).  The alkaloid camptothecin is the most commonly used inhibitor of topoisomerase I.  Water-soluble derivatives of camptothecin, such as CPT-11 and topotecan, have been examined for antineoplastic activity in colorectal cancer, non--small-cell lung cancer, lymphoma, ovarian cancer, head and neck cancer, pancreatic cancer, and breast cancer
C1905	Triterpenoid_Compound	Antineoplastic_Plant_Product	Triterpenoid Compound
C1906	Tumor_Specific_Peptide	Peptide	Tumor Specific Peptide	Protein fragments that are derived specifically from tumor cells and presented to T cells by Major Histocompatibility Complex (MHC) molecules expressed on antigen presenting cells or even on the tumors themselves.  Often used alone or as conjugates with other molecules as experimental tumor vaccines. (NCI/OSP)
C1907	Drug_Natural_Product	Pharmacologic_Substance	Drug, Natural Product|Drugs, Natural Products	Any drug derived from microorganisms, plants, or animals; also, synthesized versions of these substances or their derivatives.
C1908	Drugs_and_Chemicals	root_node	Drug or Chemical	A category of organic or inorganic substances, elements, and isotopes used in research or for the prevention, diagnosis, and /or treatment of disease states.  Includes biologically active substances that are either synthetically manufactured or endogenous substances extracted and processed to be reintroduced into an organism.  Chemicals and drugs also include hazardous substances, and naturally occurring or synthetically produced substances required to maintain life. (NCI04)
C1909	Pharmacologic_Substance	Drugs_and_Chemicals_Functional_Classification	Pharmacologic Substance|Drug|Pharmaceutical Agent|Pharmaceuticals|Pharmacologic Agente|Pharmacological Substance	A natural, synthetic or semi-synthetic substance including endogenous body substance used to diagnose, prevent, maintain, treat or analyze abnormal and normal biological functions in vivo or in vitro.
C1910	Luteinizing_Hormone-releasing_Hormone_Agonist	Agonist	Luteinizing Hormone-releasing Hormone Agonist	A substance that closely resembles LHRH, which controls the production of sex hormones. However, LHRH agonists affect the body differently than does LHRH. LHRH agonists keep the testicles from producing hormones.
C1911	Organo-Metallic_Phosphorus_Boron_Derivatives	Organic_Chemical	Organo-Metallic, Phosphorus, Boron Derivatives	Organic compounds that contains phosphorus and a metal-carbon bond with Boron atoms. (NCI)
C1912	Therapeutic_Chemokine_Other	Therapeutic_Chemokine	Other Recombinant Chemokine|Chemokines, Other|Other Therapeutic Chemokine|Recombinant Chemokine, Other	Formulated therapeutic analogs of one of a number of endogenous chemokines other than those classified as CXC, CC, C, or CX3C (previously known as alpha, beta, gamma, and delta, respectively). (NCI04)
C1913	Drugs_and_Chemicals_Structural_Classification	Drugs_and_Chemicals	Drugs and Chemicals, Structural Classification	Substances that are grouped or classified by chemical composition.(NCI)
C1914	Drugs_and_Chemicals_Functional_Classification	Drugs_and_Chemicals	Drugs and Chemicals, Functional Classification	Substances that are grouped and described by their effects on biological functions rather than by their chemical structures. (NCI)
C1915	Aromatic_Compounds	Ring_Compound	Aromatic Compounds	Historically, the term "aromatic" originally referred to the smell of selected compounds that later were found to contain benzene or fused benzene rings in the structure. In a structural sense, it designates compounds that, in accordance with the theory of Huckel, have a cyclic, delocalized (4n+2) pi-electron system. This includes arenes and their substitution products (e.g., benzene, naphthalene, toluene). The term has been generalized to include aromatic heterocyclic structures, such as thiophene and pyridine, but it is more precise to call compounds of the latter type heteroaromatic.
C1916	Nitrogen_Compound	Organic_Chemical	Nitrogen Compound	Organic or inorganic compounds that contain nitrogen as an integral part of the molecule.
C1917	P1-derived_Artificial_Chromosome	P1_Vector	P1-derived Artificial Chromosome|PAC	A cloning vector based upon the bacteriophage P1, but more modified than a P1-vector.  Used for introduction of foreign or recombinant DNA into E. coli.  Hold a larger insert than plasmids or cosmids.  PACs are maintained as circular molecules.  These vectors contain sequences necessary for packaging by P1 particles, as well as other P1 required elements.  Inserts up to 100Kb can be cloned in PACs
C1918	P1_Vector	Cloning_Vector	P1 Vector	A cloning vector derived from the bacteriophage P1.
C1919	Plasmid_Cloning_Vector	Cloning_Vector	Plasmid Cloning Vector|Plasmid Vector	A plasmid especially designed for cloning of DNA or construction of recombinant DNA molecules.  Such a cloning vector will usually have convenient restriction enzyme sites to facilitate the introduction of foreign DNA by ligation.
C1920	Attenuated_Live_Virus_Vaccine	Vaccine	Attenuated Live Virus Vaccine|Live-attenuated Vaccine	Live vaccines prepared from microorganisms which have undergone physical adaptation (e.g., by radiation or temperature conditioning) or serial passage in laboratory animal hosts or infected tissue/cell cultures, in order to produce avirulent mutant strains capable of inducing protective immunity.  Live-attenuated vaccines are used when a CD8+ T Cell (cellular cytoxicity) response is desired.
C1921	Prothymosin-L	Peptide_Hormone	Prothymosin L
C1922	Epothilone_Compound	Tubulin_Binding_Agent	Epothilone Compound|epothilones	A class of compounds isolated from the myxobacterium Sorangium cellulosum.  Similar to taxanes, epothilone compounds induce microtubule polymerization and stabilize microtubules against depolymerization conditions, thereby inhibiting mitosis. (NCI)
C1923	Nutritional_Toxin	Toxin	Nutritional Toxin	Toxins present in food or water.
C1924	Curacin_Compound	Tubulin_Binding_Agent	Curacin Compound	A class of compounds isolated from a marine cyanobacterium species (blue green alga).  Curacin compounds inhibit tubulin polymerization, thereby inhibiting mitosis and cell proliferation. (NCI)
C1925	Hen_Egg_Lysozyme	Antigen	Hen Egg Lysozyme|HEL	A soluble protein immunogen used as a model antigen to study antibody:antigen binding and B- and T-cell responses in the laboratory. (NCI04)
C1926	Heterocyclic_Amines	Amine	Heterocyclic Amines	Exhibiting a cyclic structure containing at least one amino (NH2) group, some Heterocyclic Amines are carcinogenic chemicals formed from cooking meat such as beef, pork, fowl, and fish when amino acids and creatine (found in muscle) react at high temperatures. About 17 identified heterocyclic amines that result from cooking meat may increase human cancer risk. Because of the high temperatures used, frying, broiling, and barbecuing produce the largest amounts of heterocyclic amines. (NCI04)
C1927	Enediyne_Antitumor_Antibiotic	Antineoplastic_Antibiotic|DNA_Adduct_Forming_Agent	Enediyne Antitumor Antibiotic	A class of enediyne antineoplastic antibiotics that are isolated from various Streptomyces bacterial species.  After cycloaromatization, the enediyne core of these antibiotics is converted to a benzene diradical intermediate that removes hydrogens from deoxyriboses along the minor groove of DNA, resulting in single- and double-strand breaks and apoptosis. (NCI04)
C1928	Dynemicin	Enediyne_Antitumor_Antibiotic	Dynemicin	An antitumor antibiotic of the enediyne class. It has demonstrated high DNA cleavage activity in the presence of NADPH, antimicrobial and tumor growth-inhibiting properties. Dynemicin recognizes and cleaves conformationally flexible regions of DNA. It attacks bases at 3'-side of purine residues such as 5'-AG, 5'-AT, and 5'-GC sequences. (NCI)
C1929	Signaling_Molecule	Physiology-Regulatory_Factor	Signaling Molecule	Molecules, of an unidentified chemical nature, that participate in signal transduction processes in the cell.
C1930	Dietary_Component	Food_and_Food_Product	Dietary Component	Substances introduced into the body by dietary means.
C1931	Antineoplastic_Plant_Product	Drug_Natural_Product	Antineoplastic Plant Product	Plant-derived compound used to treat cancer.
C1932	Chemical_Modifier	Drugs_and_Chemicals_Functional_Classification	Chemical Modifier	A chemical that influences the properties of another chemical or biological function. (NCI)
C1933	Ring_Compound	Organic_Chemical	Ring Compound	A cyclic compound. any compound in which the constituent atoms, or any part of them, form a ring. Used mainly in organic chemistry. SYN closed chain compound, ring compound.
C1934	Differentiation_Inducer	Cell_Differentiating_Agent	Differentiation Inducer|Differentiating Agents|Differentiation Agents	A class of agents that induce the differentiation or maturation of cells, specifically neoplastic cells, resulting in decreases in tumor growth and metastasis. (NCI04)
C1935	Anticachexia_Agent	Adjuvant	Anticachexia Agent|Anti-Cachexia Agents|Anticachexia Drugs|Anticachexias|anticachexia	Drugs which reduce the fatigue and weight loss often associated with cancer.
C1936	Transcripts	Miscellaneous_Molecular_Biology_Terms	Transcript|Transcripts	The initial RNA molecule produced by transcription.
C1937	Diagnostic_Reagent	Reagent	Diagnostic Reagent	Dyes, indicators, and other reagents.
C1938	Monoclonal_Antibody_BrE-3	Monoclonal_Antibody	Monoclonal Antibody BrE-3|BrE-3	A murine and humanized monoclonal antibody that targets epitopes of epithelial glycoprotein mucin (MUC-1) on breast cancer surfaces. (NCI)
C1939	GAGE	Tumor_Antigen	GAGE	A family of tumor antigens.  Expressed in adult normal testis and some sarcomas, melanomas, nonsmall cell lung carcinomas, head and neck tumors, and bladder tumors.
C1940	Element_or_Isotope	Inorganic_Chemical	Element	A substance whose atoms all have the same atomic number, that cannot be divided into simpler substances, and that singly or in combination constitute all matter.
C1941	Therapeutic_Tumor_Necrosis_Factor_Family_Protein	Therapeutic_Cytokine	Recombinant Tumor Necrosis Factor Family Protein|Tumor Necrosis Factor Family Protein|Tumor Necrosis Factors|tumor necrosis factor	(TOO-mer ne-KRO-sis) A type of biological response modifier (a substance that can improve the body's natural response to disease).  Three types of tumor necrosis factor have been identified: alpha, beta, and gamma. Tumor necrosis factor seems to play a role in the breakdown of cancer cells.
C1942	Linker-Oligonucleotide	Oligonucleotide	Linker-Oligonucleotide|Oligonucleotide Linker	Typically used in biomedical research, Linker-Oligonucleotides are usually short nucleic acids (DNA) that bridge or link, by complementary base pairing, two nucleic acids related by sequence and that lead to extension of the nucleic acid molecule. (NCI04)
C1943	Holmium_166	Radioisotope	Holmium 166|Ho-166	A radioactive isotope that is used to destroy cancer cells. (NCI)
C1944	YAC_Clone	Clone	YAC Clone|YAC Clones	A yeast artificial chromosome containing a specific DNA fragment.
C1945	Fruit_and_Vegetable	Food_and_Food_Product	Fruit or Vegetable	Food substances obtained from plant source. (NCI)
C1946	Histone_Deacetylase_Inhibitor	Enzyme_Inhibitor	Histone Deacetylase Inhibitor|HDAC Agent	Compounds causing hyperacetylation of histone deacetylase, an enzyme involved in the regulation of transcription, causing inhibition of cell differentiation and induction of apoptosis.(NCI)
C1947	Organic_Oxoacids	Organic_Chemical	Organic Oxoacids	Organic acids that have oxygen atoms in the acidic groups. (NCI)
C1948	_2-Amino-9_10-Epoxy-8-Oxodecanoic_Acid	Amino_Acid	2-Amino-9,10-Epoxy-8-Oxodecanoic Acid|AEO	The epoxy containing amino acid of HC toxin, a histone deacetylase inhibitor.
C1949	Food_and_Food_Product	Drugs_and_Chemicals_Functional_Classification	Food or Food Product	Processed or unprocessed substances obtained from animal, plant, microorganism and mining source that provide nutrients for living organisms to maintain biological processes or functions. (NCI)
C1950	Nut_Oil	Food_Oil	Nut Oil	Oil extracted from nuts. (NCI)
C1951	Human_Papilloma_Virus_Vaccine	Vaccine	Human Papilloma Virus Vaccine|HPV Vaccine	A recombinant vaccine of different types of HPV proteins which are well-conserved within types with a significant inter-type variation.(NCI)
C1952	Interferon_Alpha-2a	Therapeutic_Interferon_Alfa	Interferon Alpha-2a|Alferon|Alpha 2 Interferon|IFN alpha-2A|IFN-Alpha 2|Interferon Alfa|Interferon alfa 2a|Laroferon|Recombinant Interferon Alfa-2a|Roceron|Roceron-A|Roferon-A|rHuIFN-a 2a	A non-glycosylated recombinant human alpha interferon, subtype 2a, produced in the bacterium E. coli.  Interferon alpha-2a binds to its specific cell-surface receptor, resulting in the transcription and translation of genes whose protein products have antiviral, antiproliferative, anticancer, and immune modulating effects. (NCI04)
C1953	Recombinant_Interferon_Alfa-2b	Therapeutic_Interferon_Alfa	Recombinant Interferon Alfa-2b|Alfatronol|Alpha 2 Interferon 2b (Intron-A)|Glucoferon|Heberon Alfa|IFN alpha-2B|Interferon Alfa-2B|Interferon Alpha-2b|Interferon alfa 2b|Intron A|Urifron|Viraferon	A non-glycosylated recombinant interferon alpha, subtype 2b, used as an antiviral and antineoplastic agent.  Alpha interferons bind to specific cell-surface receptors, resulting in the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. (NCI04)
C1954	Nutraceutical	Food_and_Food_Product	Nutraceutical	A nutraceutical is any food or food ingredient considered to provide medical or health benefits, including the prevention and treatment of disease.  Food-based (nutrition) substances that have pharmaceutical effects on human health.
C1955	Vanilloid	Antineoplastic_Plant_Product	Vanilloid	A class of plant alkaloids which include the capsaicins
C1956	Tobacco-Associated_Carcinogen	Carcinogen	Tobacco-Associated Carcinogen	A chemical that is present in tobacco products, including pipe, cigarette and cigar as well as chewing tobacco and snuff, or that is produced during the burning of tobacco and causes a carcinogenic effect in humans.
C1957	_125IUdR	Radioconjugate	125IUdR|125I Deoxyuridine	A radiopharmaceutical comprised of a thymidine analog, 5-iodo-2''-deoxyuridine (idoxuridine), labelled with the Auger electron emitter Iodine 125 that has been used as an assay for testing cell-mediated cytotoxicity and exhibits cytotoxicity by incorporating into DNA, causing DNA strand breaks. (NCI04)
C1958	Monoclonal_Antibody_81C6	Monoclonal_Antibody	Monoclonal Antibody 81C6|Anti-Tenascin Monoclonal Antibody 81C6	A monoclonal antibody that recognizes tenascin.  Shows promise as a treatment for glioma.
C1959	Monoclonal_Antibody_170	Monoclonal_Antibody_for_Clinical_Diagnosis	Monoclonal Antibody 170	A monoclonal antibody used in immunotherapy and immunodetection of various types of cancer. (NCI)
C1960	Monoclonal_Antibody_G-250	Monoclonal_Antibody_for_Clinical_Diagnosis	Monoclonal Antibody G-250|Chimeric Monoclonal Antibody cG250|MoAb G250|Rencarex|cG250	A chimeric monoclonal antibody directed against G250, a cell surface antigen found in the majority of renal cell carcinomas. Following binding, monoclonal antibody G250 (mAb G250) may be internalized by G250 antigen-expressing renal carcinoma cells; mAb G250 may be useful as a carrier for radioisotopes and other antineoplastic therapeutic agents. (NCI05)
C1961	Monoclonal_Antibody_BC8	Monoclonal_Antibody	Monoclonal Antibody BC8|anti-CD45 Monoclonal Antibody BC8	An anti-CD45 antibody (BC8) that has specificity for hematopoietic tissues and used in targeted immunotherapy. (NCI)
C1962	Gene_Therapy_Agent	Biological_Agent	Gene Therapy Agent	Agents used in gene therapy including viral or non viral vectors, cytokines, gene complexes and genetic materials. (NCI)
C1963	Retro-Inverso_Peptide	Chemo_Immunostimulant_Adjuvant	Retro-Inverso Peptide|All-D-Retro Peptide|Retro-Enantio Peptide|Retro-Inverso Analog|Retro-Inverso Analogue|Retro-Inverso Derivative|Retro-Inverso Isomer	Peptides built of D-amino acids in the reversed sequence order.  These may adopt structures similar to their L-counterparts while being more resistant to proteolytic degradation.
C1964	Miniantibody	Peptide	Miniantibody|MiniAb	A peptide resembling the complementary determining region of an antibody and retaining its specificity.  These are being studied for therapeutic and research use.
C1965	Lutein	Carotenoid	Lutein|(3R,3'R,6'R)-beta,epsilon-Carotene-3,3'-diol|LUT|Leutin|Xanthophyll|Xanthophylls	Lutein (LOO-teen) is a oxygenated carotenoid found in vegetables and fruits.  lutein is found in the macula of the eye, where it is believed to act as a yellow filter. Lutein acts as an antioxidant, protecting cells against the damaging effects of free radicals.
C1966	Image_Enhancement_Agent	Reagent	Image Enhancement Agent	Agents used to enhance image formation of body structures and functions in the detection and diagnosis of disease by anatomic or receptor localization or being activated by processes in the body. (NCI)
C1967	Tyrosine_Kinase_Inhibitor	Protein_Kinase_Inhibitor	Tyrosine Kinase Inhibitor|PTK Inhibitors|Protein Tyrosine Kinase Inhibitors|TK Inhibitors|tyrosine kinase inhibitors	A family of drugs that interfere with cell communication and may prevent tumor growth. They are being studied as a treatment for cancer.
C1968	Topoisomerase-II_Inhibitor	Topoisomerase_Inhibitor	Topoisomerase-II Inhibitor|Topoisomerase-II Inhibitors	Substances that either stabilize DNA-protein complexes damaging DNA (e g., teniposide), or those that inhibit the catalytic activity of the enzyme (e.g., merbarone, ICRF-187). Despite their differences in action, these agents all block cells in G2/M
C1969	Dolastatin_9	Dolastatin_Compound	Dolastatin 9	A substance originally isolated from the marine mollusk Dolabella auricularia with potential neoplastic activity.  Dolastatin 9 binds to tubulin and blocks microtubule assembly, thereby inhibiting mitosis. (NCI04)
C1970	Matrix_Metalloproteinase_Inhibitor	Angiogenesis_Inhibitor|Enzyme_Inhibitor	Matrix Metalloproteinase Inhibitor|MMP Inhibitor	A class of antiangiogenic agents with antimetastatic properties.  A matrix metalloproteinase inhibitor blocks the activities of matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation and inhibiting angiogenesis, tumor growth and invasion, and metastasis. (NCI04)
C1971	Angiogenesis_Activator_Inhibitor	Angiogenesis_Inhibitor	Angiogenesis Activator Inhibitor	An agent or endogenous factor that inhibits angiogenesis by blocking the action of an endogenous, pro-angiogenic substance(s). (NCI04)
C1972	Deferoxamine_Hydrochloride	Deferoxamine	Deferoxamine Hydrochloride|Ba 29837|Ba-29837|Deferoxamine HCl|Deferoxamine hydrochloride	The hydrochloride salt form of deferoxamine, an iron chelating agent.  Deferoxamine chelates iron from intra-lysosomal ferritin and hemosiderin forming ferrioxamine, a water-soluble chelate excreted by the kidneys and in the feces via the bile.  This agent does not readily bind iron from transferrin, hemoglobin, myoglobin or cytochrome. (NCI)
C1973	CancerVax	Polyvalent_Melanoma_Vaccine	CancerVax|C-VAX	CancerVax is an allogenic polyvalent vaccine composed of irradiated but viable cells from three melanoma cell lines and Bacille Calmette-Guerin (BCG). The vaccine was shown to induce humoral and cellular immune responses against multiple tumor antigens present on melanoma cells. A significant correlation between the magnitude of immune responses to the vaccine and the overall survival of patients receiving adjuvant therapy with CancerVax after surgical resection of stage III and IV melanoma was reported. Vaccine testing in patients with advanced colon cancer merits further investigation. (NCI)
C1974	Quassinoid_Agent	Antineoplastic_Plant_Product	Quassinoid Agent|QUASSINOID	A group of phytochemicals isolated from several species of the plant family Simaroubaceae with potential antineoplastic activity.  Quassinoid agents also exhibit antimalarial, antiprotozoal and antiproliferative activities. (NCI04)
C1975	Bruceanol_Agent	Quassinoid_Agent	Bruceanol Agent	A group of quassinoid phytochemicals extracted from species of the plant Brucea with potential antineoplastic activity. (NCI04)
C1976	Depsipeptide_Antibiotic	Antineoplastic_Antibiotic	Depsipeptide Antibiotic|Depsipeptides	A class of linear or cyclic antineoplastic antibiotics isolated from microorganisms or synthetically derived.  These antibiotics exhibit potent antitumor, antibiotic, and immunosuppressive properties. (NCI04)
C1977	ALVAC-CEA_B7_1_Vaccine	ALVAC-CEA_Vaccine	ALVAC-CEA B7.1 Vaccine|ALVAC CEA B7.1 Vaccine	A cancer vaccine that uses a viral vector system derived from the canarypox virus engineered to target the carcinoembryonic antigen (CEA). It causes infected cells to temporarily display CEA and activates the immune system to attack the tumor cells. (NCI)
C1978	GVAX_Cancer_Vaccine	Autologous_Cell_Vaccine	GVAX Cancer Vaccine	GVAX cancer vaccines are autologous cell vaccines comprised of tumor cells which have been irradiated and genetically modified to secrete granulocyte-macrophage colony stimulating factor (GM-CSF), a hormone which plays a key role in stimulating the body's immune response to vaccines.
C1979	GVAX_Lung_Cancer_Vaccine	GVAX_Cancer_Vaccine	GVAX Lung Cancer Vaccine|CG8123|GVAX Autologous Lung Cancer Vaccine	An autologous lung cancer vaccine consisting of patient-specific lung cancer cells genetically modified to secrete granulocyte-macrophage colony stimulating factor (GM-CSF), an immunostimulatory cytokine. GM-CSF modulates the proliferation and differentiation of a variety of hematopoietic progenitor cells with some specificity towards stimulation of leukocyte production and may reverse treatment-induced neutropenias. This agent also promotes antigen presentation, up-regulates antibody-dependent cellular cytotoxicity (ADCC), and increases interleukin-2-mediated lymphokine-activated killer cell function and may augment host antitumoral immunity.  For safety, cells are irradiated prior to vaccination. (NCI04)
C1980	Autologous_Cell_Vaccine	Tumor_Cell_Derivative_Vaccine	Autologous Cell Vaccine|AC vaccine|autologous tumor cell vaccine	A therapeutic agent produced by isolating tumor cells from an individual and processing these tumor cells into a vaccine formulation in vitro; the vaccine is then administered to the individual from whom the tumor cells were isolated. Typically combined with an adjuvant immunostimulant, an autologous cell vaccine may elicit a cytotoxic T-lymphocytic immune response to cell surface-expressed tumor-associated antigens (TAAs), resulting in tumor cell death. (NCI04)
C1981	Autologous-Cell_Melanoma_Vaccine	Autologous_Dinitrophenyl_Vaccine|Melanoma_Vaccine	Autologous-Cell Melanoma Vaccine|M-Vax	An autologous-cell vaccine for melanoma.
C1982	Autologous_Dinitrophenyl_Vaccine	Autologous_Cell_Vaccine	Autologous Dinitrophenyl Vaccine|AUT DNP-vaccine	A vaccine consisting of autologous cancer cells modified with the hapten, Dinitrophenyl. The treatment program consists of multiple intradermal injections of irradiated DNP-modified autologous tumor cells mixed with bacillus Calmette-Guerin. (NCI)
C1983	Allogenic_Cell_Vaccine	Tumor_Cell_Derivative_Vaccine	Allogenic Cell Vaccine|allogenic tumor cell vaccine	A vaccine composed of tumor cells isolated from the tumor of one patient, killed and processed, and administered to another patient to stimulate cytotoxic immune responses to a similar tumor cell type. The cells found in this type of whole-cell vaccine express many cell-surface tumor-associated antigens. This vaccine is frequently administered with an adjuvant immunostimulant. (NCI04)
C1984	OncoVAX	Antineoplastic_Vaccine	OncoVAX	An autologous vaccine comprised of irradiated tumor cells obtained from the patient after surgery and it is administered along with the BCG vaccine. It is designed to provoke a specific immune response against cancer cells.(NCI)
C1985	APC8015_Vaccine	Autologous_Cell_Vaccine|Dendritic_Cell_Tumor_Peptide_Vaccine	APC8015 Vaccine|APC 8015|APC8015|PAP-Loaded DC|PAP-Loaded DC (Provenge)|Prostatic Acid Phosphatase (PAP)-loaded Dendritic Cell Vaccine|Provenge	A cell-based vaccine composed of autologous antigen-presenting peripheral blood mononuclear cells (enriched for a dendritic cell fraction) that have been exposed to a recombinant protein consisting of granulocyte-macrophage colony-stimulating factor (GM-CSF) fused to prostatic-acid phosphatase (PAP), a protein expressed by prostate cancer cells.  Upon administration, the vaccine may stimulate an antitumor T-cell response against tumor cells expressing PAP. (NCI05)
C1986	p53_Peptide_Vaccine	Autologous_Cell_Vaccine	p53 Peptide Vaccine|P53 (264-272) peptide vaccine and tumor-specific mutant p53 peptide vaccine|individualized mutant p53 peptide-pulsed cultured autologous dendritic cell vaccine	A peptide-based cancer vaccine composed of amino acids 264 to 272 of the wild-type protein encoded by the P53 gene. p53 peptide vaccine may elicit an HLA-A2.1-restricted cytotoxic T lymphocyte immune response against tumor cells that overexpress p53 protein. (NCI04)
C1987	Dendritic_Cell_Tumor_Peptide_Vaccine	Dendritic_Cell_Vaccine	Dendritic Cell Tumor Peptide Vaccine|DC tumor peptide vaccine|dendritic cells pulsed with tumor peptide	A vaccine composed of dendritic cells pulsed with peptide epitopes that stimulate cytotoxic T lymphocyte anti-tumor activity. (NCI)
C1988	Dendritic_Cell_Tumor_Cell_Lysate_Vaccine	Dendritic_Cell_Tumor_Peptide_Vaccine	Dendritic Cell Tumor Cell Lysate Vaccine|DC tumor cell lysate vaccine|dendritic cell-pulsed tumor cell lysate vaccine	A vaccine composed of dendritic cells pulsed with tumor cells lysates that stimulate a potent and specific cell mediated anti-tumor immune response. (NCI)
C1990	Mannosylerythritol_Lipid	Differentiation_Inducer	Mannosylerythritol Lipid	A yeast glycolipid biosurfactant with potential antineoplastic activity.  Mannosylerythritol lipid activates protein kinase signal cascades, resulting in cell differentiation, condensation of chromatin, DNA fragmentation, G1 phase cell-cycle arrest, and apoptosis of tumor cells. (NCI04)
C1991	_2-3-Ethylureido_Pyridine	Differentiation_Inducer	2-(3-Ethylureido)-Pyridine	A ureido-derivative of pyrimidine developed to induce leukemic cell differentiation.  This agent has been shown to induce erythroleukemia cell differentiation. (NCI04)
C1992	_4-Methyl-2-3-Ethylureido_Pyridine	Differentiation_Inducer	4-Methyl-2-(3-Ethylureido)-Pyridine	A ureido-derivative of pyrimidine developed to induce leukemic cell differentiation.  This agent ahs been shown to induce erythroleukemia cell differentiation. (NCI04)
C1993	_2_6-Dimethyl-2-3-Ethylureido_Pyridine	Differentiation_Inducer	2,6-Dimethyl-2-(3-Ethylureido)-Pyridine	A ureido-derivative of pyrimidine developed to induce leukemic cell differentiation.  This agent has been shown to induce erythroleukemia cell differentiation. (NCI04)
C1994	_2_6-Dimethyl-4-3-Ethylureido_Pyridine	Differentiation_Inducer	2,6-Dimethyl-4-(3-Ethylureido)-Pyridine	A ureido-derivative of pyrimidine developed to induce leukemic cell differentiation.  This agent has been shown to induce erythroleukemia cell differentiation. (NCI04)
C1995	_6-3-Ethylureido_Uridine	Differentiation_Inducer	6-(3-Ethylureido)-Uridine	An ureido-derivative of pyridine and a potent inducer of neoplastic cell differentiation. (NCI04)
C1996	_1_3-Dimethyl-6-3-Ethylureido_Uridine	Differentiation_Inducer	1,3-Dimethyl-6-(3-Ethylureido)-Uridine	A ureido-derivative of pyrimidine developed to induce leukemic cell differentiation.  This agent has been shown to induce erythroleukemia cell differentiation. (NCI04)
C1997	_4-3-Ethylureido_Cytosine	Differentiation_Inducer	4-(3-Ethylureido)-Cytosine	A ureido-derivative of pyrimidine developed to induce leukemic cell differentiation.  This agent has been shown to induce erythroleukemia cell differentiation. (NCI04)
C1998	_5-Methyl-4-3-Ethylureido_Cytosine	Differentiation_Inducer	5-Methyl-4-(3-Ethylureido)-Cytosine	An ureido-derivative of pyrimidine and a potent inducer of neoplastic cell differentiation. (NCI04)
C1999	CD30_Immunotoxin	Immunotoxin	CD30 Immunotoxin|Ber-H2 immunotoxin|Ki-1 immunotoxin|anti Ber-H2 immunotoxin|anti CD30 immunotoxin|anti Ki-1 immunotoxin	An immunotoxin composed of an anti-CD30 monoclonal antibody and a toxin moiety, which targets antigen-positive cells and causes cytotoxic activity. (NCI)
C2000	TP3_Immunotoxin	Immunotoxin	TP3 Immunotoxin|Anti-p80|Anti-p80 Immunotoxin	An immunotoxin composed of an anti-p80 monoclonal antibody and a toxin moiety, which targets antigen-positive cells and causes cytotoxic activity. (NCI)
C2001	J591_Monoclonal_Antibody	Monoclonal_Antibody	Monoclonal Antibody J591|J591	Monoclonal recombinant antibody J591 (mAb HuJ591) recognizes the extracellular domain of prostate specific membrane antigen (PSMA), a cell surface peptidase highly expressed by malignant prostate epithelial cells and vascular endothelial cells of numerous solid tumor malignancies. Early results of clinical Phase I and II studies indicate that mAb HuJ591 represents targeted therapy to PSMA and has therapeutic potential in disseminated prostate cancer and other urological and solid tumor malignancies and did not result in a host immune response to the antibody. (NCI)
C2002	CD22_Immunotoxin	Immunotoxin	CD22 Immunotoxin|anti-CD22 immunotoxin	An immunotoxin composed of an anti-CD22 monoclonal antibody and a toxin moiety, which targets antigen-positive cells and causes cytotoxic activity. (NCI)
C2003	Antihuman_Endoglin_Immunotoxin	Immunotoxin	Antihuman Endoglin Immunotoxin|K4-2C10 Immunotoxin	Monoclonal antibody K4-2C10 conjugated with deglycosylated ricin A chain.  This antibody recognizes human endoglin (Transforming Growth Factor P Receptor III), present on tumor vasculature.
C2004	SGN-15	Retired_Concepts	SGN-15
C2005	SGN-14	Monoclonal_Antibody	SGN-14	A genetically engineered monoclonal antibody that targets CD40. (NCI)
C2006	SGN-17_19	Monoclonal_Antibody	SGN-17/19	A substance composed of a monoclonal antibody-enzyme fusion protein (SGN-17), containing a cloned binding region of the L49 monoclonal antibody and the enzyme beta-lactamase, and an inactive prodrug form of Mephalan (SGN-19) used in Antibody Directed Enzyme Therapy (ADEPT). (NCI)
C2007	SGN-30	Monoclonal_Antibody	Monoclonal Antibody SGN-30|Anti-CD30 Monoclonal Antibody|SGN-30	A genetically-engineered, chimeric mouse-human, anti-CD30 monoclonal antibody with potential antineoplastic activity. Monoclonal antibody SGN-30 specifically binds to the receptor CD-30, a member of the tumor necrosis factor receptor super-family, which may be overexpressed on the surfaces of Hodgkin's lymphoma cells and anaplastic-large cell lymphoma cells. After binding to CD30, this agent interferes with the G1 phase of the cell cycle, thereby inducing growth arrest and apoptosis in susceptible tumor cell populations.
C2008	MDX-447	Retired_Concepts	MDX-447|Bispecific Antibody MDX447|BsAb MDX447|EMD 82633|Epidermal Growth Factor Receptor-Directed Bispecific Antibody MDX-447	A humanized bispecific antibody containing Fab portions reactive with epidermal growth factor receptor (EGFR)-expressing tumor cells and Fc gamma RI (CD64) receptor-expressing effector cells.
C2009	MDX-220	Bispecific_Antibody	Monoclonal Antibody MDX-220|MDX-220	A bispecific antibody containing a patented Trigger antibody and a humanized antibody that targets TAG-72.  TAG-72 is overexpressed in a variety of cancers.
C2010	MDX-22	Monoclonal_Antibody	Monoclonal Antibody MDX-22|MDX-22|MDX-22 Monoclonal Antibody	A monoclonal antibody used to purge leukemia cells from bone marrow. (NCI)
C2011	MDX-4	Retired_Concepts	MDX-4
C2012	EMD_72000	Monoclonal_Antibody	EMD 72000	A humanized monoclonal antibody targeting the epidermal growth factor receptor (EGFR) and exhibiting anti-tumor activity.  EMD 72000 competitively inhibits growth factor binding to EGFR, inhibiting ligand-mediated activation and ultimately impaired cell growth and proliferation. (NCI)
C2013	BEC-2	Monoclonal_Antibody	BEC-2	An anti-idiotypic monoclonal antibody that mimics the ganglioside GD3, a tumor antigen on the surface of certain types of tumor cells and stimulates a stronger immune response to cells expressing natural GD3. (NCI)
C2014	Novel_Erythropoiesis_Stimulating_Protein	Retired_Concepts	Novel Erythropoiesis Stimulating Protein|NESP
C2015	Abarelix	Gonadotropin_Releasing_Hormone_Inhibitor	Abarelix|ABARELIX|PPI-149|Plenaxis|R-3827	A peptide antagonist of gonadotropin-releasing hormone. Abarelix binds to the luteinizing hormone-releasing hormone receptor, thereby inhibiting the secretion of gonadotropin releasing hormone and ultimately reducing testosterone production. (NCI)
C2016	GEM_220	Angiogenesis_Activator_Inhibitor|Mixed-Backbone_Oligonucleotide	GEM 220|Gene Expression Modulator 220	A mixed-backbone antisense oligonucleotide that is complementary to a pro-angiogenic vascular endothelial growth factor (VEGF) mRNA sequence.  Because of its antiangiogenic properties, GEM 220 has been studied as a potential antineoplastic agent. (NCI04)
C2017	Steroidal_Aromatase_Inhibitor	Aromatase_Inhibitor	Steroidal Aromatase Inhibitor|Steroidal Androstenedione Aromatase Inhibitors|Steroidal Estrogen Synthase Inhibitors|Steroidal Estrogen Synthetase Inhibitors	An agent with steroidal structure that inhibits aromatase causing a reduction in the synthesis of estrogen or blocking estrogen action at the receptor level in the tumor. (NCI)
C2018	Non-Steroidal_Aromatase_Inhibitor	Aromatase_Inhibitor	Non-Steroidal Aromatase Inhibitor|Non-Steroidal Androstenedione Aromatase Inhibitor|Non-Steroidal Estrogen Synthase Inhibitor|Non-Steroidal Estrogen Synthetase Inhibitor|nonsteroidal aromatase inhibitors	A family of drugs that decrease the production of sex hormones (estrogen or testosterone) and slow the growth of tumors that need sex hormones to grow.
C2019	Dihydropyrimidine_Dehydrogenase_Inhibitor	Enzyme_Inhibitor	Dihydropyrimidine Dehydrogenase Inhibitor|DPD Inhibitors|Dihydrothymin Dehydrogenase Inhibitors|Dihydrouracil Dehydrogenase Inhibitors|NADP Inhibitors	An agent that inhibits dihydropyrimidine dehydrogenase, a rate-limiting enzyme in the catabolism of 5-Fluorouracil and may be used to improve the efficacy of 5-Fluorouracil. (NCI)
C2020	Farnesyl_Transferase_Inhibitor	Enzyme_Inhibitor	Farnesyl Transferase Inhibitor|FTI|Farnesyl Transferase Inhibitors|Farnesyltransferase Inhibitors|Protein Farnesyltransferase Inhibitors	Substances that inhibit farnesyl transferase, an enzyme involved in ras post-translational modification, having the potential to inhibit the oncogenic activity of ras. (NCI)
C2021	Thymidylate_Synthase_Inhibitor	Enzyme_Inhibitor	Thymidylate Synthase Inhibitor|Thymidylate Synthetase Inhibitors|thymidylate synthase inhibitors	A family of drugs that block DNA synthesis and may prevent tumor cell growth. They are being studied as a treatment for cancer.
C2022	Gonadotropin-Releasing_Hormone_Analog	Therapeutic_Hormone	Gonadotropin-Releasing Hormone Analog|LH-RH Analogs|Luteinizing Hormone-Releasing Hormone analogs|luteinizing hormone-releasing hormone agonist	(LOO-tin-eye-zing.AG-o-nist) LH-RH agonist.  A drug that inhibits the secretion of sex hormones.  In men, LH-RH agonist causes testosterone levels to fall.  In women, LH-RH agonist causes the levels of estrogen and other sex hormones to fall.
C2023	Autologous-Cell_Leukemia_Vaccine	Autologous_Cell_Vaccine	Autologous-Cell Leukemia Vaccine|L-Vax	An autologous therapeutic vaccine for the treatment of acute myelogenous leukemia. This vaccine is prepared from blood samples of patients following their first relapse.  Tumor cells extracted from blood sample are modified with hapten, a process that makes the cells appear foreign to the patient's body and results in stimulating immune response against the cancer. (NCI)
C2024	ISIS_2503	Phosphorothioate_Oligonucleotide	ISIS 2503|H-RAS Antisense|ISIS-2503	A substance that is being studied in the treatment of cancer.
C2025	Tyrphostin_A8	Tyrphostin_Compound	Tyrphostin A8|AG 10	A member of the tyrphostin family of tyrosine kinase inhibitors that inhibits the GTPase activity of transducin and competitively inhibits calcineurin activity. (NCI)
C2026	Tyrphostin_A9	Tyrphostin_Compound	Tyrphostin A9|AG 17	A member of the tyrphostin family of tyrosine kinase inhibitors that exhibits anti-proliferative activity by selectively inhibiting the platelet-derived growth factor receptor tyrosine kinase. It inhibits phosphorylation, uncouples oxidative phosphorylation and induces apoptosis and cell growth arrest in certain cancer cell lines. (NCI)
C2027	Tyrphostin_A48	Tyrphostin_Compound	Tyrphostin A48|AG 112	A member of the Tyrphostin family of tyrosine kinase inhibitors that inhibits epidermal growth factor receptor tyrosine kinase. (NCI)
C2028	Tyrphostin_AG_370	Tyrphostin_Compound	Tyrphostin AG 370|AG 370	A member of the Tyrphostin family of tyrosine kinase inhibitors that inhibits platelet derived growth factor (PDGF), autophosphorylation and PDGF-induced mitogenesis in fibroblast. (NCI)
C2029	Tyrphostin_B44	Tyrphostin_Compound	Tyrphostin B44(-)|AG 527	An enantiomer of tyrosine kinase inhibitor that inhibits epidermal growth factor receptor kinase autophosphorylation and phosphorylation of the poly-GAT. (NCI)
C2030	Tyrphostin_AG_1288	Tyrphostin_Compound	Tyrphostin AG 1288|AG 1288	A protein tyrosine kinase inhibitor that blocks tumor necrosis factor alpha induced cytotoxicity. (NCI)
C2031	Tyrphostin_AG_1295	Tyrphostin_Compound	Tyrphostin AG 1295|6,7-Dimethyl-2-phenylquinoxaline|AG 1295	A member of the Tyrphostin family of tyrosine kinase inhibitors that inhibits signal transduction through platelet-derived growth factor receptor and selectively attenuates smooth muscle cell growth. (NCI)
C2032	Tyrphostin_AG_1433	Tyrphostin_Compound	Tyrphostin AG 1433|AG 1433	A member of the Tyrphostin family of tyrosine kinase inhibitors that selectively inhibits platelet-derived growth factor beta-receptor kinase and angiogenesis. (NCI)
C2033	Bis-Tyrphostin	Tyrphostin_Compound	Bis-Tyrphostin	A protein tyrosine kinase inhibitor that competitively inhibits epidermal growth factor receptor kinase activity. (NCI)
C2034	Tyrphostin_A63	Tyrphostin_Compound	Tyrphostin A63|AG 43	A protein tyrosine inhibitor that is used as a negative control for the inhibition of epidermal growth factor receptor tyrosine kinase activity. (NCI)
C2035	Tyrphostin_A1	Tyrphostin_Compound	Tyrphostin A1|4-Methoxybenzylidene malononitrile|AG 9	An inactive agent that is used as a negative control for the inhibition of epidermal growth factor receptor tyrosine kinase activity. (NCI)
C2036	Ketanserin_Tartrate	Ketanserin	Ketanserin Tartrate|Perketan|R-49945|Serepress|Sufrexal	The tartrate salt form of Ketanserin. (NCI)
C2037	IMC-1C11	Monoclonal_Antibody	IMC-1C11|IMC-1C11 Chimerized Monoclonal Antibody	A monoclonal antibody that selectively binds with KDR and blocks the vascular endothelial growth factor-induced endothelial cell proliferation and prevents angiogenesis. (NCI)
C2038	DC101_Monoclonal_Antibody	Monoclonal_Antibody	Monoclonal Antibody DC101|DC101	A monoclonal antibody that inhibits binding of vascular endothelial growth factor to its receptor, thereby inhibiting angiogenesis and tumor growth. (NCI)
C2039	Bevacizumab	Angiogenesis_Activator_Inhibitor|Monoclonal_Antibody_Anti-VEGF	Bevacizumab|Anti-VEGF|Anti-VEGF Humanized Monoclonal Antibody|Anti-VEGF RhuMAb|Avastin|Bevacizumab (rhuMAb VEGF)|Recombinant Humanized Anti-VEGF Monoclonal Antibody|Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor|RhuMAb VEGF|bevacizumab|rhuMabVEGF	A monoclonal antibody that may prevent the growth of blood vessels from surrounding tissue to a solid tumor.
C2040	Texaphyrin	Porphyrin	Texaphyrin	Natural blood pigments that selectively localize in tissues with high rates of metabolism such as cancers and inflammation. They also selectively localize and generate reactive oxygen species that induce apoptosis. (NCI)
C2041	KF-58333	Radicicol	KF-58333|(1aR,2Z,4E,6E,14R,15aR)-8-Chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-6H-oxireno[e][2]benzoxacyclotetradecin-6,12(7H)-dione 6-[O-[2-(2-Oxo-1-pyrrolidinyl)ethyl]oxime]|KF58333	A novel oxime derivative of radicicol that destabilizes the hsp90 client proteins, such as erbB2, raf-1 and AKT, which are essential for tumor cell growth and survival. (NCI)
C2042	AG_1732	Tyrphostin_Compound	AG 1732|AG-1732	A tyrphostin compound inhibiting receptor autophosphorylation by inhibiting protein tyrosine kinase and is used to study receptor function. (NCI)
C2043	Labetuzumab	Monoclonal_Antibody	Labetuzumab|CEA-Cide|Humanized Anti-CEA Monoclonal Antibody	A humanized monoclonal antibody that recognizes carcinoembryonic antigen.
C2044	In_111_DAC	Radioconjugate	In 111 DAC|Indium-111 diethylenetriaminepentaacetate adenosylcobalamin	A radioconjugate comprised of a Vitamin B12 compound, Diethylenetriaminepentaacetate Adenosylcobalamin, linked to Indium 111.  Since tumors require a greater degree of this vitamin, In 111 might be useful in distinguishing malignant cells from non-malignant cells.(NCI)
C2045	MMI270	Matrix_Metalloproteinase_Inhibitor	MMI270|(2R)-N-Hydroxy-2-[[(4-methoxyphenyl)sulfonyl](3-pyridinylmethyl)amino]-3-methylbutanamide Monohydrochloride|CGS27023|CGS27023A|MMI 270B CGS27023A|N-hydroxy-2(R)-[(4-methoxysulfony) (3-picolyl)-amino]-3-metylbutaneamide hydrochloride monohydrate|N-hydroxy-2(R)-[[4- methoxysulfonyl](3-picolyl)amino]-3-methylbutaneamide hydrochloride	An orally-active synthetic hydroxamic acid derivative with potential antineoplastic activity.  MMI270 inhibits a broad spectrum of matrix metalloproteinases (MMPs) (specifically MMP-1, 2, 3, 9, and 13), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.  This agent may also downregulate lymphangiogenesis, resulting in decreased lymphatic system-related metastasis. (NCI04)
C2046	TNP-40	Retired_Concepts	TNP-40	A synthetic analogue of fungal protein that inhibits endothelial cell growth and angiogenesis. (NCI)
C2047	Prolactin_16-kD_Fragment	Endothelial_Cell_Inhibitor	Prolactin 16-kD Fragment|16K PRL	A 16 kD N-terminal fragment of prolactin formed endogenously by cleavage of intact prolactin.  Possessing anti-angiogenic properties, prolactin 16-kD fragment inhibits the pro-angiogenic effects of basal fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) on endothelial cell proliferation, migration, and capillary organization.  This agent also induces caspase-mediated endothelial cell apoptosis and upregulates the expression of plasminogen activator inhibitor-1 (PAI-1); PAI-1 inhibits the activity of urokinase, an enzyme essential to angiogenesis. (NCI04)
C2048	A-65	Miscellaneous_Angiogenesis_Inhibitor	A-65	An amide analogue of Trichostatin A studied for potential antineoplastic activity.  A-65 inhibits zinc-dependent histone deacetylase, inducing terminal cell differentiation and anti-angiogenic activity. (NCI04)
C2049	D_24851	Antimitotic_Agent	D 24851	A synthetic cytotoxic small molecule that binds to tubulin.  Bound to tubulin, D 24851 inhibits tubulin polymerization, cell cycle progression at the G2/M phase and, consequently, tumor cell growth.  This agent has been shown to be active against multi-drug resistant tumors. (NCI04)
C2050	Alpha_V_Beta_Inhibitor	Endothelial-Specific_Integrin-Survival_Signaling_Inhibitor	Alpha V Beta Inhibitor	A group of angiogenesis inhibitors that act by blocking the action of alpha(v)beta integrins.  An alpha(v) beta integrin inhibitor blocks the activity of an endothelial cell-surface expressed alpha(v)integrin, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. (NCI04)
C2051	Spongistatin	Tubulin_Binding_Agent	Spongistatin	A cytotoxin that interacts with microtubules and inhibits mitosis causing tumor cell death. (NCI)
C2052	Cephalostatin	Unclassified_Chemotherapy_Agent	Cephalostatin	The cephalostatins comprise a family of more than 30 trisdecacyclic bissteroidal pyrazines with extreme cytotoxicity against human tumors, isolated from the African marine worm Cephalodiscus gilchristi. The mechanism of action of these compounds remains unknown. Beside a steroidal platform, critical features implicated in the pharmacophore include a set of covalently linked polar and nonpolar domains and the spiroketals. It was shown that cephalostatin 1 induces a novel pathway of receptor-independent apoptosis that selectively uses Smac/DIABLO (second mitochondria-derived activator of caspases/direct inhibitor of apoptosis-binding protein with a low isoelectric point) as a mitochondrial signaling molecule. Apoptosis was found to be dependent on caspase activity because the pan-caspase inhibitor benzyloxycarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone blocks cephalostatin 1-mediated DNA fragmentation. (NCI)
C2053	T-1622	Ozone-based_Agent	T-1622	An ozonide of Terpene designed to oxidize tumor cells and control metastasis. (NCI)
C2054	BCI_Immune_Activator	Immunostimulant	BCI Immune Activator|Modified Keyhole Limpet Hemocyanin	A purified Keyhole Limpet Hemocyanin, a potent antigenic protein capable of eliciting both humoral and cellular immune responses against tumor cells. (NCI)
C2055	Allogenic_Glioma_Cancer_Vaccine	Allogenic_Cell_Vaccine	Allogenic Glioma Cancer Vaccine	A vaccine composed of killed glioma cancer cells from another patient for use in immunotherapy. (NCI)
C2056	Neu-Sensamide	Radiosensitizing_Agent	Neu-Sensamide|Neu-metoclopramide	The N-substituted benzamide metoclopramide, a potential radiosensitizer, which inhibits DNA repair and induces apoptosis. (NCI)
C2057	APC_8024	Dendritic_Cell_Tumor_Peptide_Vaccine	APC 8024|APC8024	A cell-based vaccine targets tumors expressing the HER2/neu marker.  HER-2/neu is a growth factor receptor, and its overexpression has been associated with a number of cancers including breast, ovarian, colon and lung cancers.  APC8024 comprise of autologous antigen-presenting peripheral blood mononuclear cells (APCs) that have been exposed to HER2/neu protein and can be administered to the patient.  These cells may stimulate an antitumor T-cell response to cancer cells expressing HER2/neu. (NCI04)
C2058	BIBH_1	Monoclonal_Antibody	BIBH 1	A monoclonal antibody directed against fibroblast activation protein, alpha.
C2059	BP16_Vaccine	Antineoplastic_Vaccine	BP16 Vaccine	A synthetic 16mer mimic of MUC-1.
C2060	Carcinoembryonic_Antigen_Peptide-1_Vaccine	Antineoplastic_Vaccine	Carcinoembryonic Antigen Peptide-1 Vaccine	A cancer vaccine comprised of an epitope from the Carcinoembryonic Antigen obtained from cancer cells that can stimulate an immune response against tumor cells. (NCI)
C2061	Monoclonal_Antibody_3A1	Monoclonal_Antibody	Monoclonal Antibody 3A1|MAb 3A1|MOAB 3A1	A murine monoclonal antibody that recognizes CD7 (previously known as 3A1), a cell surface antigen expressed by most normal mature peripheral T cells and T cell acute lymphoblastic leukemias.  Monoclonal antibody 3A1 is used to diagnose and classify T cell malignancies.  This agent can also be conjugated to toxins for potential use in cancer immunotherapy. (NCI04)
C2062	LGD_1550	Retinoic_Acid_Agent	LGD 1550|(2E,4E,6E)-7-[3,5-Bis(1,1-dimethylethyl)phenyl]-3-methyl-2,4,6-octatrienoic Acid	An orally-active synthetic aromatic retinoic acid agent with potential antineoplastic and chemopreventive activities.  LGD 1550 selectively binds to all three retinoic acid receptors (RAR-alpha, RAR-beta, and RAR-gamma), resulting in alterations in the expression of genes responsible for cell differentiation and proliferation.  This agent also acts as an inhibitor of activator protein 1 (AP-1), a protein that mediates trophic responses and malignant transformation. (NCI04)
C2063	HPV-11_Vaccine	Human_Papilloma_Virus_Vaccine	HPV-11 Vaccine|MEDI-501	A vaccine directed against Human Papillomavirus Type 11 that causes majority of the genital warts and anogenital cancers. (NCI)
C2064	GBC-590	Lectin_Inhibitor	GBC-590|GCS 100	A modified citrus pectin exhibiting antimetastatic activity.  GBC-590 binds to and inhibits galectin-3 receptor, resulting in mitigation of the metastatic process. (NCI)
C2065	Tridolgosir_Hydrochloride	Cytoprotective_Agent|Golgi_Alpha-Mannosidase_II_Inhibitor	Tridolgosir Hydrochloride|GD0039	An orally-active synthetic hydrochloride salt form of swainsonine, an inhibitor of Golgi alpha-mannosidase II.  Tridolgosir inhibits formation of carbohydrate structures affecting cell-cell adhesion, resulting in decreases in tumor growth or metastasis.  This agent also stimulates the immune system. (NCI04)
C2066	Votumumab	Monoclonal_Antibody	Votumumab|88BV59H21-2V67-66|HumaSPECT|Monoclonal Antibody 88BV59	A human monoclonal antibody that targets the cytokeratin tumor-associated antigen and is used for the detection of recurrence and/or metastases of carcinoma of the colon or rectum. (NCI)
C2067	K-RAS_Protein_Vaccine	Antineoplastic_Vaccine	K-RAS Protein Vaccine	A vaccine composed of tumor-associated antigen, mutant K-ras, which produces both a cytotoxic and helper T cell response to challenge tumor cells expressing the relevant K-ras oncogene. (NCI)
C2068	MGV_Vaccine	Melanoma_Vaccine	MGV Vaccine|BMS 248967|GM2/GD2 gangliosides-KLH Vaccine	A vaccine that contains the GM2 and GD2 antigens separately coupled to the carrier protein Keyhole Limpet Hemocyanin and mixed with QS-21 adjuvant (an immune system stimulant), designed to stimulate a patient's immune system to control or eradicate residual cancer cells after surgery, radiation or chemotherapy. (NCI)
C2069	Defosfamide	Nitrogen_Mustard_Compound	Defosfamide|612-Asta|Desmofosfamide|Desmophosphamidum	A nitrogen mustard compound that cross-links with DNA, causing inhibition of DNA synthesis. (NCI)
C2070	Mannomustine	Nitrogen_Mustard_Compound	Mannomustine|Degranol|Mannitol Mustard|Mannitol mustard|Mannomustine Hydrochloride|Mannomustine hydrochloride	A nitrogen mustard derivative that cross-links with DNA, causing inhibition of DNA synthesis. It may be used to treat certain cancers, but may cause a higher incidence of leukemia and a dose-related incidence of lung tumors in animals. (NCI)
C2071	Phenamet	Nitrogen_Mustard_Compound	Phenamet	A nitrogen mustard compound that cross-links with DNA, causing inhibition of DNA synthesis. (NCI)
C2072	Uredepa	Ethylenimine_Compound	Uredepa	An aziridine alkylating agent that cross-links with DNA, causing inhibition of DNA synthesis. It has been used as a chemosterilant. (NCI)
C2073	Monoclonal_Antibody_B1	Monoclonal_Antibody	Monoclonal Antibody B1	A monoclonal antibody that targets CD20, a B-cell-specific cell surface protein expressed on mature B lymphocytes. (NCI)
C2074	Denopterin	Folate_Antagonist	Denopterin	A folate analog that interferes with RNA, DNA, and protein synthesis. (NCI)
C2075	Leninan	Chemo_Immunostimulant_Adjuvant	Leninan
C2076	Polyamine_Inhibitory_Agent	Antineoplastic_Agent	Polyamine Inhibitory Agent	Polyamine analogues that inhibit the synthesis or stimulate the catabolism of polyamines, intracellular compounds that are critical in cell growth and death pathways. (NCI)
C2077	Bioreductive_Agent	Pharmacologic_Substance	Bioreductive Agent|Hypoxia Selective Agent|Hypoxic Cell Cytotoxic Agent|Hypoxic Cell Sensitizer|Selective Hypoxic Cell Cytotoxic Agent	Antitumor agents that are activated by biological reduction and have selective efficacy against hypoxic solid tumors. (NCI)
C2078	Folic_Acid_Derivative	Nephroprotective_Agent	Folic Acid Derivative	A group of vitamin B9 derivatives that act as precursors, cofactor of enzymes and inhibitors involved in various biosynthesis of amino acids and, proteins and nucleic acid components. (NCI)
C2079	Cardioprotective_Agent	Chemoprotective_Agent	Cardioprotective Agent	Agents administered before, with, or after cancer therapy to reduce or prevent damage or toxicity to the heart. (NCI)
C2080	Cytoprotective_Agent	Chemoprotective_Agent	Cytoprotective Agent|Cytoprotectants|Cytoprotective Drugs	Agents administered before, with, or after cancer therapy to reduce or prevent damage or toxicity to the normal cells. (NCI)
C2081	Hepatoprotective_Agent	Chemoprotective_Agent	Hepatoprotective Agent|Hepatoprotectants|Hepatoprotective Agents|Hepatoprotective Drugs	Agents administered before, with, or after cancer therapy to reduce or prevent damage or toxicity to the liver. (NCI)
C2082	Uroprotective_Agent	Chemoprotective_Agent	Uroprotective Agent|Uroprotectants|Uroprotective Drugs	Agents administered before, with, or after cancer therapy to reduce or prevent damage or toxicity to the urinary tract. (NCI)
C2083	DNA_Methyltransferase_Inhibitor	Enzyme_Inhibitor	DNA Methyltransferase Inhibitor	Compounds that inhibits the hypermethylation of DNA in malignant cells, restoring suppressor gene expression and re-establish controlled growth and differentiation of cells. (NCI)
C2084	N_N-Dibenzyl_Daunomycin	Anthracycline_Antibiotic	N,N-Dibenzyl Daunomycin|N,N-dibenzyl daunorubicin|N,N-dibenzyldaunomycin|N,N-dibenzyldaunorubicin	The N-alkylated analogue of the anthracycline antineoplastic antibiotic daunomycin.  N,N-Dibenzyl Daunomycin interacts with topoisomerase II, thereby inhibiting DNA replication and repair and promoting DNA fragmentation.  This agent is less cardiotoxic than daunomycin. (NCI04)
C2085	Chlorodihydropyrimidine	Dihydropyrimidine_Dehydrogenase_Inhibitor	Chlorodihydropyrimidine|5-Chlorodihydropyrimidine	An agent that inhibits Dihydropyrimidine Dehydrogenase, a rate-limiting enzyme in the catabolism of 5-Fluorouracil (5-FU), blocking degradation of orally administered 5-FU and increasing bioavailability. (NCI)
C2086	Inosine_5-Phosphate_Dehydrogenase_Inhibitor	Enzyme_Inhibitor	Inosine 5'-Phosphate Dehydrogenase Inhibitor|IMPDH Inhibitors	Agents that inhibit Inosine 5'-Phosphate Dehydrogenase, an regulatory enzyme of guanosine triphosphate biosynthesis, causing possible inhibition of cell proliferation and malignancy.(NCI)
C2087	Inosine_Monophosphate_Dehydrogenase_Inhibitor	Enzyme_Inhibitor	Inosine Monophosphate Dehydrogenase Inhibitor	Substances that block Inosine Monophosphate Dehydrogenase, a key enzyme involved in the biosynthesis of guanine nucleotides that regulate cell proliferation and differentiation, and has application in anti-cancer and immunosuppressive therapy. (NCI)
C2088	Ornithine_Decarboxylase_Inhibitor	Enzyme_Inhibitor	Ornithine Decarboxylase Inhibitor|Ornithine Decarboxylase Inhibitors	Substances that inhibit ornithine decarboxylase, the first and rate-limiting enzyme that catalyzes the conversion of Ornithine to Putrescine that may affect cellular growth, differentiation, transformation, and apoptosis. (NCI)
C2089	Protein_Kinase_C_Inhibitor	Protein_Kinase_Inhibitor	Protein Kinase C Inhibitor	Substances that inhibit a subgroup of protein kinase that catalyze certain cell protein phosphorylation reactions involved in inflammation, mitogenesis, and differentiation of cells and have application in cancer treatment and prevention. (NCI)
C2090	S-Adenosyl-Methionine_Decarboxylase_Inhibitor	Enzyme_Inhibitor	S-Adenosyl-Methionine Decarboxylase Inhibitor|S-Adenosyl-Methionine Decarboxylase Inhibitors	Agents that inhibit S-Adenosyl-Methionine Decarboxylase, an enzyme involved in the biosynthesis of the polyamines, spermidine, and spermine, and are being developed as potential antitumor and/or antiparasitic agents. (NCI)
C2091	Milotane	Retired_Concepts	Milotane
C2092	Gonadotropin_Releasing_Hormone_Inhibitor	Hormone_Antagonist	Gonadotropin Releasing Hormone Inhibitor|Gonadrotropin Releasing Hormone Antagonists	Agents that inhibit gonadotropin releasing hormone, a key regulator of sex hormones involved in hormone dependent cancers. (NCI)
C2093	_131_I-Ethiodized_Oil	Radioconjugate	131 I-Ethiodized Oil	A radioimmunoconjugate comprised of ethyl esters of poppy seed oil labelled with Iodine 131 for use as diagnostic aid and anticancer agent. (NCI)
C2094	Receptor_Mediated_Permeabilizer_Agent	Retired_Concepts	Receptor Mediated Permeabilizer Agent	Agents that dilate blood vessels, loosen tight junctions and selectively deliver entrapped agents into tumor cells by receptor interaction. (NCI)
C2095	Lopinavir	Anti-HIV_Agent|Protease_Inhibitor	Lopinavir|ABT-378/r|LOPINAVIR	An anti-HIV protease inhibitor
C2096	Lopinavir_Ritonavir	Anti-HIV_Agent|Protease_Inhibitor	Lopinavir/Ritonavir|Kaletra	A combination anti-HIV protease inhibitor from Abbott Laboratories.  Brand name is Kaletra.
C2097	Telomerase_RNA_Component	Functional_RNA	Telomerase RNA Component|TERC|hTERC|hTR	Telomerase RNA component is the ribonucleic acid subunit of telomerase.  Telomerase uses the species-specific RNA sequences as the templates to synthesize GC-rich strand of telomeres, chromosome ends.
C2098	Canarypox_Vectors	Pox_Virus_Vectors|Viral_Vector	Canarypox Vectors	Cloning vector derived from the canarypox virus.  Similar to vaccinia virus vectors but elicit greater response in vaccinia-immune individuals.  Often used to express foreign genes in mammalian cells as a component of a vaccine.
C2099	Nephroprotective_Agent	Chemoprotective_Agent	Nephroprotective Agent|Nephroprotective Agents	Agents administered before, with, or after cancer therapy to reduce or prevent damage or toxicity to the kidney. (NCI)
C2100	GV-1301	Antineoplastic_Vaccine	GV-1301	Antineoplastic vaccine being developed against liver cancer. (NCI)
C2101	CyA_246	Immunostimulant	CyA 246	A bacterial cell wall mimetic.  It is a potent inducer of cytokines and is beginning Phase II trials in combination with chemotherapy for patients with non-small cell lung cancer.
C2102	TLC_ELL-12	Caspase_Inhibitor	TLC ELL-12|1-0-Octadecyl-2-O-methyl-Sn-3-glycero-phosphocholine Liposome|ELL-12	A liposomal formulation of the ether lipid 1-O-octadecyl-2-O-methyl-sn-glycero-3-phosphocholine with potential antineoplastic activity.  TLC ELL-12 induces tumor cell apoptosis via mitochondria- and caspase-mediated mechanisms.  Liposomal encapsulation reduces the free agent's hemolytic toxicity. (NCI04)
C2103	I_131_Monoclonal_Antibody_Lym-1	Radioimmunoconjugate	I 131 Monoclonal Antibody Lym-1|Iodine I 131 Monoclonal Antibody Lym-1|Oncolym	A radioimmunoconjugate comprised of a monoclonal antibody, Lym-1,directed against HLA-Dr10 protein, a cell surface marker present on over 80% of lymphoma cells, labelled with Iodine 131. (NCI)
C2104	Vincristine_Liposomal	Vincristine	Vincristine Liposomal|Lipid-Encapsulated Vincristine|Liposomal Vincristine|Onco TCS|VincaXome|Vincacine|Vincristine Liposome|Vincristine, Liposomal	A liposomal formulation of Vincristine designed to reduce toxicity and improve efficacy.  Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI)
C2105	T-20	Anti-HIV_Agent	T-20|ENFUVIRTIDE|Enfuvirtide|Fuzeon	An anti-HIV drug developed to inhibit the fusion of HIV with host cells, preventing the virus from entering cells.
C2106	Monoclonal_Antibody_703D4	Monoclonal_Antibody	Monoclonal Antibody 703D4	A monoclonal antibody which recognizes the heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1, a potential epithelial marker in the detection of early lung cancer, on cell surfaces. This protein is responsible for posttranscriptional regulation of gene expression by capping, splicing, polyadenylation, and cytoplasmic transport of mRNAs. Its detection in bronchial lavage specimens was shown to predict predicts the presence of a neoplasm with 96% sensitivity and 82% specificity earlier than routine chest X rays or sputum cytology. (NCI)
C2107	Anthrapyrazole_Antibiotic	Antineoplastic_Antibiotic|Intercalating_Agent|Topoisomerase-II_Inhibitor	Anthrapyrazole Antibiotic|Anthrapyrazoles	A class of antibiotics related to the anthracycline antineoplastic antibiotics.  The anthrapyrazole antibiotics intercalate into DNA and interact with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  These agents may also block cell cycle division.  In the presence of electron donors, some anthrapyrazole antibiotics cause single-strand breaks in DNA via photosensitization by visible light.  These agents are less cardiotoxic than doxorubicin.  (NCI04)
C2108	ImmunoCyt	Monoclonal_Antibody_for_Clinical_Diagnosis	ImmunoCyt	A combination of 3 fluorescent-tagged monoclonal antibodies.  Recently licensed for screening of bladder cancer recurrence by urine test.
C2109	Topoisomerase-IV_Inhibitor	Topoisomerase_Inhibitor	Topoisomerase-IV Inhibitor	A group of antibiotics that targets DNA topoisomerase IV.  All quinolone derivatives belong to topo IV inhibitors.  The other target of these substances is bacterial gyrase.  Mutations in the quinolone resistance-determining region (QRDR) of subunits of both topo IV and gyrase confer resistance to single-step mutants.
C2110	Miscellaneous_Alkylating_Agent	Antineoplastic_Alkylating_Agent	Miscellaneous Alkylating Agent	Alkylating agents with non-specific classification based on mechanism of action, therapeutic use, or chemical properties. (NCI)
C2111	Miscellaneous_Antineoplastic_Antibiotic	Antineoplastic_Antibiotic	Miscellaneous Antineoplastic Antibiotic	A group of unrelated agents that are not members of other antineoplastic antibiotic subcategories. (NCI04)
C2112	Miscellaneous_Biologic_Response_Modifier	Biological_Response_Modifier	Miscellaneous Biologic Response Modifier|Miscellaneous Biological Response Modifiers	Biologic response modifiers with non-specific classification based on mechanism of action, therapeutic use, or chemical properties. (NCI)
C2113	Miscellaneous_Chemoprotective_Agent	Chemoprotective_Agent	Miscellaneous Chemoprotective Agent	Chemoprotective agents with non-specific classification based on mechanism of action, therapeutic use, or chemical properties. (NCI)
C2114	Mustard_Agent	Antineoplastic_Alkylating_Agent	Mustard Agent	A blistering agent primarily containing sulfur and chlorine groups that alkylate with DNA to form DNA crosslinks, causing inhibition of DNA synthesis. (NCI)
C2115	DNA_Minor_Groove_Binding_Agent	DNA_Groove_Binding_Agent	DNA Minor Groove Binding Agent	Antineoplastic agents that either covalently or noncovalently bind to the minor groove of DNA, causing inhibition of DNA synthesis. (NCI)
C2116	Selective_Estrogen_Receptor_Down_Regulator	Antiestrogen	Selective Estrogen Receptor Down Regulator|SERD|SERDs	Agents that selectively bind to estrogen receptors on breast cancer cells and stop estrogen-dependent cell proliferation. (NCI)
C2117	Carbohydrate_Processing_Inhibitor	Antineoplastic_Agent	Carbohydrate Processing Inhibitor|CPIs	A class of agents that interfere with the intracellular glycoprotein glycosylation pathway.  Intracellular glycosylation of glycoproteins is involved in many cellular processes, including lymphocyte trafficking, immune cell stimulation, embryogenesis, and cancer metastasis. (NCI04)
C2118	Unclassified_Chemotherapy_Agent	Antineoplastic_Agent	Unclassified Chemotherapy Agent	Chemotherapy agents with non-specific classification based on mechanism of action, therapeutic use, or chemical properties. (NCI)
C2119	Golgi_Alpha-Mannosidase_II_Inhibitor	Carbohydrate_Processing_Inhibitor|Enzyme_Inhibitor	Golgi Alpha-Mannosidase II Inhibitor	A class of agents that inhibit Golgi alpha-mannosidase II, a key enzyme involved in the protein glycosylation pathway.  These agents inhibit formation of carbohydrate structures that affect cell-cell adhesion, resulting in decreases in tumor growth and metastasis. (NCI04)
C2120	Lectin_Inhibitor	Anti-Adhesion_Agent	Lectin Inhibitor	Substances that inhibit lectin, a protein that binds carbohydrate on cell surfaces and causes cell agglutination. (NCI)
C2121	Ozone-based_Agent	Antineoplastic_Agent	Ozone-based Agent	Compounds that contain Ozone, a highly active oxidizing agent that have application in the treatment of bacterial and viral infections, cancer diagnosis, treatment, and evaluation of disease progression. (NCI)
C2122	Cell_Differentiating_Agent	Antineoplastic_Agent	Cell Differentiating Agent	A class of agents that either induce or inhibit the differentiation or maturation of cells, specifically neoplastic cells, resulting in decreases in tumor growth and metastasis. (NCI04)
C2123	Monoclonal_Antibody_16_88	Monoclonal_Antibody	Monoclonal Antibody 16.88|16.88	A human immunoglobulin M class monoclonal antibody that recognizes a 30- to 45-kilo dalton intracellular antigen expressed in colorectal cancer cells and is being developed for applications in Antibody-Targeted Immunotherapy of cancer. (NCI)
C2124	Radioconjugate	Radiopharmaceutical_Compound	Radioconjugate|Radio Conjugates	Compounds comprised of a radioactive agent linked to a pharmacological substance to be used to prevent, diagnose, or treat various diseases, including cancer. (NCI)
C2125	Sodium_Iodide_Radioactive	Radioconjugate	Radioactive Sodium Iodide	A radioactive iodide salt that distributes mainly within the extracellular body fluid and selectively concentrates in certain organ tissues, including the thyroid gland. (NCI)
C2126	Sodium_Phosphate_Radioactive	Radioconjugate	Sodium Phosphate, Radioactive	A radioactive phosphate salt that distributes readily into intra and extracellular compartments and accumulates in rapidly dividing cancer cells leading to cell death. (NCI)
C2127	cGMP_Phosphodiesterase_Inhibitor	Phosphodiesterase_Inhibitor	cGMP Phosphodiesterase Inhibitor	Substances that inhibit the enzyme cGMP Phosphodiesterase leading to cGMP-dependent protein kinase activation, resulting in vasodilation and induction of apoptosis.(NCI)
C2128	Sulfur_Mustard_Compound	Mustard_Agent	Sulfur Mustard Compound	Vesicant compounds originally used as chemical warfare agents. At high temperatures, is in vapor form and readily absorbed through the skin, eyes, airway, and GI tract.  It reacts with DNA, RNA, and proteins, compromising normal cell function.(NCI)
C2129	Mustard_Prodrug	Mustard_Agent	Mustard Prodrug	An agent when activated is converted into an active mustard alkylating agent at the tumor site, causing DNA cross-linking.  These compounds may be used in antibody-directed enzyme prodrug therapy (ADEPT).(NCI)
C2130	Gamma-Glutamylcysteine_Synthetase_Inhibitor	Enzyme_Inhibitor	Gamma-Glutamylcysteine Synthetase Inhibitor|GCS Inhibitors|Glutathione Synthesis Inhibitors	Substances that inhibit gamma-Glutamylcysteine Synthetase, a rate-limiting enzyme in glutathione (GSH) biosynthesis, causing possible sensitization of tumor cells to alkylating agents, redox agents, and radiotherapy.(NCI)
C2131	Differentiation_Inhibitor	Cell_Differentiating_Agent	Differentiation Inhibitor	Substances that inhibits differentiation of cells.(NCI)
C2132	Bombesin_Antagonist	Differentiation_Inhibitor	Bombesin Antagonist|BN Antagonists	Substances that antagonize bombesin, an endogenous neurotransmitter found in many animals, and affect smooth muscle, gastrin secretion, and renal function.(NCI)
C2133	Cytidine_Triphosphate_Synthetase_Inhibitor	Enzyme_Inhibitor	Cytidine Triphosphate Synthetase Inhibitor|CTP Synthetase Inhibitors|CTS Inhibitors	Substances that inhibit Cytidine Triphosphate Synthetase, resulting in inhibition of de novo purine biosynthesis.(NCI)
C2134	_06-Alkylguanine-DNA_Alkyltransferase_Inhibitor	Enzyme_Inhibitor	06-Alkylguanine-DNA Alkyltransferase Inhibitor|06-Alkylguanine-DNA Alkyltransferase Inhibitors	Substances that inhibit 06-Alkylguanine-DNA Alkyltransferase, a DNA repair enzyme, and interferes with the enzymes ability to remove alkyl adducts from DNA.
C2135	Cytidine_Deaminase_Inhibitor	Enzyme_Inhibitor	Cytidine Deaminase Inhibitor	Substances that inhibit Cytidine Deaminase, an enzyme that catalyzes the deamination of cytosine, preventing deamination of different cytosine nucleoside analogs.(NCI)
C2136	Malignancy-Associated_Hypercalcemia_Inhibitor	Adjuvant	Malignancy-Associated Hypercalcemia Inhibitor|MAH Inhibitors	Substances that demonstrate efficacy in treating tumor induced hypercalcemia.(NCI)
C2137	Glutathione_Transferase_Inhibitor	Enzyme_Inhibitor	Glutathione Transferase Inhibitor	Substances that inhibit Glutathione Transferase, enzymes involved with cellular defense, and may inhibit drug resistance in cancer cells.(NCI)
C2138	Near-Infrared_Fluorescence_Imaging_Probe	Image_Enhancement_Agent	Near-Infrared Fluorescence Imaging Probe|Near Infrared Fluorescence Imaging Probe	For non-invasive detection, Protease-Activated Near-Infrared Fluorescent Probes are used for in vivo Imaging of tumors in Mice.
C2139	Immunostimulant	Biological_Response_Modifier	Immunostimulant	Substances that stimulate the immune system.(NCI)
C2140	Adjuvant	Pharmacologic_Substance	Adjuvant|ADJ	Agents given to augment or stimulate a primary therapy or alleviate adverse effects caused by the primary therapy.
C2141	Chemo_Immunostimulant_Adjuvant	Immunoadjuvant	Chemo Immunostimulant Adjuvant|Chemo Immunostimulant Adjuvants	Adjuvant used in chemotherapy that acts by stimulating the immune system.(NCI)
C2142	Surgical_Adjuvant	Retired_Concepts	Surgical Adjuvant	Adjuvants used in surgical procedures.(NCI)
C2143	Endothelial_Cell_Inhibitor	Angiogenesis_Inhibitor	Endothelial Cell Inhibitor	A substance that inhibits the growth, migration, and proliferation of endothelial cells and/or induces endothelial cell apoptosis, resulting in the inhibition of angiogenesis. (NCI04)
C2144	Endothelial-Specific_Integrin-Survival_Signaling_Inhibitor	Angiogenesis_Inhibitor	Endothelial-Specific Integrin/Survival Signaling Inhibitor	A class of angiogenesis inhibitors that act by blocking the action of endothelial integrins.  An endothelial-specific integrin/survival signaling inhibitor binds to and blocks the activity of endothelial-specific integrins, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. (NCI04)
C2145	Miscellaneous_Angiogenesis_Inhibitor	Angiogenesis_Inhibitor	Miscellaneous Angiogenesis Inhibitor	A class of agents that act by inhibiting angiogenesis via mechanisms of action that are different from those of other defined classes of angiogenesis inhibitors. (NCI04)
C2146	Miscellaneous_Antimetabolite	Antimetabolite	Miscellaneous Antimetabolite	Antimetabolites with non-specific mechanisms of action.(NCI)
C2147	Kinase_Inhibitor	Retired_Concepts	Kinase Inhibitor|Kinase Inhibitor Drugs
C2148	Protein_Kinase_A_Inhibitor	Protein_Kinase_Inhibitor	Protein Kinase A Inhibitor	Substances that inhibit the action of Protein Kinase A, causing disruption of a protein phosphorylation cascade in certain signal transduction pathways.(NCI)
C2149	Mitogen-Activated_Protein_Kinase_Inhibitor	Protein_Kinase_Inhibitor	Mitogen-Activated Protein Kinase Inhibitor|MAPK Inhibitors	Substances that inhibit Mitogen-Activated Protein Kinase, enzymes involved with signal transduction, and may inhibit cell proliferation.(NCI)
C2150	Ribonucleotide_Reductase_Inhibitor	Enzyme_Inhibitor	Ribonucleotide Reductase Inhibitor	Substances that inhibit Ribonucleotide Reductase, an enzyme converting ribonucleoside diphosphates to deoxyribonucleotide diphosphate precursors for de novo DNA synthesis, causing inhibition of DNA synthesis and cell growth.(NCI)
C2151	Purine_Nucleoside_Phosphorylase_Inhibitor	Enzyme_Inhibitor	Purine Nucleoside Phosphorylase Inhibitor	Substances that inhibit Purine Nucleoside Phosphorylase, an enzyme involved in the purine salvage pathway that metabolizes inosine and guanosine to hypoxanthine, increasing deoxyguanosine triphosphate, causing inhibition of DNA synthesis and cell growth.(NCI)
C2152	Phosphatidylinositide_3-Kinase_Inhibitor	Enzyme_Inhibitor	Phosphatidylinositide 3-Kinase Inhibitor|PI3-Kinase Inhibitors	Substances that inhibit Phosphatidylinositide 3-Kinase, an enzyme involved in many signalling pathways, and may affect many cellular functions, including mitogenesis, differentiation and apoptosis.(NCI)
C2153	Dihydrofolate_Reductase_Inhibitor	Enzyme_Inhibitor	Dihydrofolate Reductase Inhibitor|DHFR Inhibitor	Substances that inhibit Dihydrofolate Reductase interfering with the conversion of Dihydrofolate to Tetrahydrofolate, causing inhibition of nucleotide biosynthesis and protein synthesis.(NCI)
C2154	Palmitoyl_Thioesterase_Inhibitor	Retired_Concepts	Palmitoyl Thioesterase Inhibitor	Substances that inhibit Palmitoyl Thioesterase, an enzyme that removes palmitate from certain cysteine residues in proteins.(NCI)
C2155	Tyrosine_Hydroxylase_Inhibitor	Enzyme_Inhibitor	Tyrosine Hydroxylase Inhibitor	Substances that inhibit Tyrosine Hydroxylase, an enzyme that catalyzes the conversion of tyrosine to dihydroxyphenylalanine, causing inhibition of catecholamine synthesis.(NCI)
C2156	Duocarmycin_Antibiotic	Antineoplastic_Antibiotic|DNA_Minor_Groove_Binding_Agent	Duocarmycin Antibiotic|Duocarmycins	A class of spirocycloporpylhexadienone-containing antineoplastic antibiotics synthetically derived or isolated from various Streptomyces bacterial species.  Duocarmycin antibiotics alkylate DNA by binding to adenine-thymine (A-T)- rich sequences in the minor groove of DNA, thereby inhibiting DNA replication and inducing apoptosis. (NCI04)
C2157	Adenosine_Deaminase_Inhibitor	Enzyme_Inhibitor	Adenosine Deaminase Inhibitor|ADA Inhibitor|Adenosine deaminase inhibitor	Substances that inhibit Adenosine Deaminase, an enzyme involved with purine metabolism.
C2158	Glutamine_Amidotransferase_Inhibitor	Enzyme_Inhibitor	Glutamine Amidotransferase Inhibitor	Substances that inhibit Glutamine Amidotransferase, an enzyme involved with de novo purine synthesis, resulting in inhibition of DNA synthesis.(NCI)
C2159	Protein_Phosphatase_Inhibitor	Enzyme_Inhibitor	Protein Phosphatase Inhibitor	Substances that inhibit Protein Phosphatase, an enzyme that removes serine or threonine phosphate groups from phosphoproteins, and may control cell proliferation.(NCI)
C2160	Proteasome_Inhibitor	Enzyme_Inhibitor	Proteasome Inhibitor	Substances that inhibit Proteasome, a multicatalytic cellular structure responsible for ATP-dependent proteolysis, and may induce apoptosis.(NCI)
C2161	DNA_Groove_Binding_Agent	DNA_Binding_Agent	DNA Groove Binding Agent	Agents that bind covalently or non-covalently in the major or minor groove of DNA and can disrupt DNA replication.(NCI)
C2162	DNA_Major_Groove_Binding_Agent	DNA_Groove_Binding_Agent	DNA Major Groove Binding Agent	Agents that bind to the major groove of DNA, interfering with DNA replication.(NCI)
C2163	DNA_Adduct_Forming_Agent	DNA_Binding_Agent	DNA Adduct Forming Agent	Agents forming adducts with DNA, causing DNA damage and possible mutagenesis.(NCI)
C2164	Phosphorothioate_Oligonucleotide	Antisense_Agent	Phosphorothioate Oligonucleotide|Oligonucleotide Phosphorothioates
C2165	Mixed-Backbone_Oligonucleotide	Antisense_Agent	Mixed-Backbone Oligonucleotide|MBO|Mixed-Backbone Oligonucleotides	Second generation of antisense agents with segments of modified phosphorothioate oligonucleotides. The most extensively studied and used agents contain 2'-substituted modifications, such as 2'-O-methyl. In animal models, such modifications were associated with improved in vivo stability, oral bioavailability, and markedly decreased concentration-related adverse events that were common for the first generation of oligonucleotides and have been attributed to sequence-independent and sequence-specific effects. (NCI)
C2166	Combination_Anti-Infective_Agent	Anti-Infective_Agent	Combination Anti-Infective Agent	A combination of two or more anti-infective agents in a single product to increase the products effectiveness.(NCI)
C2167	Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor	Tyrosine_Kinase_Inhibitor	Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor|EGFR Blocker|EGFR Inhibitor|EGFR Tyrosine Kinase Inhibitor|EGFR Tyrosine Kinase Inhibitors|EGFR-TK Inhibitor|Epidermal Growth Factor Receptor Inhibitor|Epidermal Growth-Factor Receptor Tyrosine Kinase Inhibitors	Substances that inhibit Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase, involved with signal transduction pathways, and may be useful in treating tumors that over express EGFR.(NCI)
C2168	Adenylosuccinate_Synthetase_Inhibitor	Enzyme_Inhibitor	Adenylosuccinate Synthetase Inhibitor|Adenylosuccinate Synthetase Inhibitors	Substances that inhibit Adenylosuccinate Synthetase, an enzyme involved in purine metabolism, and interferes with DNA, RNA, and ATP biosynthesis.(NCI)
C2169	Dihydroorotate_Dehydrogenase_Inhibitor	Enzyme_Inhibitor	Dihydroorotate Dehydrogenase Inhibitor|Dihydroorotate Dehydrogenase Inhibitors	Substances that inhibit Dihydroorotate Dehydrogenase, an enzyme involved in pyrimidine synthesis, and interferes with DNA and RNA synthesis.(NCI)
C2170	Orotidylate_Decarboxylase_Inhibitor	Enzyme_Inhibitor	Orotidylate Decarboxylase Inhibitor|Orotidylate Decarboxylase Inhibitors|Orotidylic Acid Decarboxylase Inhibitor	Substances that inhibit Orotidylate Decarboxylase, an enzyme involved in pyrimidine synthesis, and interferes with DNA and RNA synthesis.(NCI)
C2171	Cyclobutane_Pyrimidine_Dimer	Pyrimidine_Dimer	Cyclobutane Pyrimidine Dimer	A dimer consisting of two adjacent pyrimidines covalently jointed by a cyclobutane ring, inhibiting DNA replication.(NCI)
C2172	Gene_Transduction_Agent	Biological_Agent	Gene Transduction Agent|Gene Therapy Vectors|Gene Transduction Vectors	Agents used to transport genes or genetic material to a target tissue, including viruses, liposomal encapsulation, direct naked DNA injection, or molecular conjugates.(NCI)
C2173	Viral_Vector	Gene_Transduction_Agent	Viral Vector|viral vector	A viral gene transduction agent used to transfer genes or genetic materials, such as retroviruses and adenoviruses.(NCI)
C2174	Non-Viral_Vector	Gene_Transduction_Agent	Non-Viral Vector	Non-viral gene transduction agents used to transfer genes or genetic materials, such as bacterial and lipid complexes.(NCI)
C2175	Gene-Vector_Complex	Gene_Therapy_Agent	Gene-Vector Complex	A complex composed of a viral or non-viral gene transduction agent and gene or genetic material.
C2176	Viral_Vector-Gene_Complex	Gene-Vector_Complex	Viral Vector-Gene Complex	A gene-vector complex composed of a gene or genetic material and a viral gene transduction agent.(NCI)
C2177	Non-Viral_Vector-Gene_Complex	Gene-Vector_Complex	Non-Viral Vector-Gene Complex	A gene-vector complex composed of a gene or genetic material and a non-viral gene transduction agent.(NCI)
C2178	Transduction_Gene	Biological_Agent	Transduction Gene|Vector Mediated Transfer Genes	A gene transferred via a vector to a target tissue for use in Gene Therapy.(NCI)
C2179	Fusion_Toxin	Toxin	Fusion Toxin	A receptor-targeted complex comprised of a truncated toxin fused to a hormone, growth factor, or immunologic agent (i.e. antibody) that binds to the tumor cell allowing the toxin to kill the cell following internalization.(NCI)
C2180	Vasopressin_Antagonist	Hormone_Antagonist	Vasopressin Antagonist	Substances that antagonize vasopressin, causing, disruption of extracellular fluid volume regulation, vasodilation, and decreased blood pressure and vascular resistance.(NCI)
C2181	Steroidal_Estrogen	Therapeutic_Estrogen|Therapeutic_Steroid_Hormone	Steroidal Estrogen	A predominantly female hormone derived from cholesterol belonging to the family of Steroid Hormones and is responsible for maintaining the health of reproductive tissues, breast, skin, and brain.  By-products of estrogen metabolism are thought to cause breast and prostate cancer.(NCI)
C2182	Non-Steroidal_Estrogen	Therapeutic_Estrogen	Non-Steroidal Estrogen	Estrogens that are not steroids, but have a structural configuration resembling steroids and may mimic steroidal estrogen effect or bind to estrogen receptors.(NCI)
C2183	Hypothalmic_Hormone	Peptide_Hormone	Hypothalamic Hormone	Releasing and inhibiting hormones secreted by the neurosecretory neurons of the hypothalamus binding to the receptors of the anterior pituitary cells and modulating the release of hormones the pituitary secretes.(NCI)
C2184	_3-Hydroxysteroid_Dehydrogenase_Inhibitor	Enzyme_Inhibitor	3-Hydroxysteroid Dehydrogenase Inhibitor|3-HSD Inhibitor	Substances that inhibit 3-Hydroxysteroid Dehydrogenase, an enzyme involved with the biosynthesis of steroid hormones, causing inhibition of steroid hormone synthesis.
C2185	Cyclin-Dependent_Kinase_Inhibitor_Drug	Protein_Kinase_Inhibitor	Cyclin-Dependent Kinase Inhibitor Drug	Agents that inhibit Cyclin-dependent Kinase, enzymes that regulate cell cycle progression, and may promote differentiation, induce apoptosis, and inhibit angiogenesis.(NCI)
C2186	Diarylsulfonylurea_Compound	Unclassified_Chemotherapy_Agent	Diarylsulfonylurea Compound|Diarylsulfonylureas	A sulfonylurea compound containing aryl groups developed originally as a herbicide and has exhibited antitumor activity.(NCI)
C2187	FVII_Icon	Immunoconjugate	FVII Icon|FVII/Fc Icon|MFVII/Fc Icon	A fusion protein of clotting factor VII with the Fc portion of an IgG1 antibody.  In the lab it can target to the blood vessels of solid tumors and initiate an immune response that results in the destruction of the blood vessel and death of the tumor.
C2188	Alkylphosphocholine_Compound	Differentiation_Inducer|Signal_Transduction_Inhibitor	Alkylphosphocholine Compound|APC|Alkylphosphocholine|Alkylphospholipid|Alkylphospholipids	A class of ether-linked lysophosphatidylcholines with potential antineoplastic activity.  Exhibiting anti-proliferative and immunomodulatory properties, alkyl-phosphocholine compounds modulate cell membrane permeability, phospholipid metabolism, and intracellular growth signal transduction pathways and induce cytotoxic macrophages, cell differentiation, and apoptosis. (NCI04)
C2189	Signal_Transduction_Inhibitor	Antineoplastic_Agent	Signal Transduction Inhibitor|signal transduction inhibitors	A family of drugs that may prevent the ability of cancer cells to multiply quickly and invade other tissues.
C2190	Alcohol	Alcohol_Chemical_Class|Substance_of_Abuse	Alcohol|ALC|ALCOHOL|Absolute Ethanol|Absolute ethanol|ETHANOL|Ethanol|Methylcarbinol	A colorless organic liquid also known as ethyl alcohol or grain alcohol.  Ethanol's primary physiologic effects involve the central nervous system.  Depending on the dose delivered, ethanol behaves as an anxiolytic, a depressant, or a general anesthetic.  Ethanol-induced immunosuppression involves dysregulation of CD4+ T cells. (NCI04)
C2191	Small_Interfering_RNA	Small_RNA	Small Interfering RNA|siRNA	21- and 22-nucleotide double-stranded RNAs.  These are the mediators of a sequence-specific messenger RNA degradation process known as RNA interference.  They are generated by ribonuclease III cleavage from longer dsRNAs.
C2192	TRICOM	Immunostimulant	TRICOM|B7-1, ICAM-1, LFA-3|B7-1, intercellular adhesion molecule-1, and leukocyte function-associated antigen-3	TRIad of COstimulatory Molecules (B7-1, ICAM-1 and LFA-3).  An immunostimulant.
C2193	Monoclonal_Antibody_2C4	Monoclonal_Antibody	Monoclonal Antibody 2C4|2C4|2C4 Antibody|MoAb 2C4	A humanized monoclonal antibody that inhibits HER receptor dimerization.
C2194	BAY_43-9006	Raf_Kinase_Inhibitor	Sorafenib|BAY 43-9006|BAY 43-9006 Tosylate Salt|BAY 43-9006 tosylate (BAY 54-9085)|BAY 54-9085	A synthetic compound targeting growth signaling and angiogenesis.  Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis.
C2195	BLP25	Antineoplastic_Vaccine	BLP25	A MUCI peptide liposomal vaccine.
C2196	Antimetastatic_Agent	Antineoplastic_Agent	Antimetastatic Agent	Agents that prevent or impair tumor metastasis.(NCI)
C2197	Anti-Adhesion_Agent	Antimetastatic_Agent	Anti-Adhesion Agent	Agents that prevent metastasis by interfering with the aggregation of tumor cells.(NCI)
C2198	Nonnarcotic_Analgesic	Analgesic_Agent	Nonnarcotic Analgesic|nonopioid	A drug that is not an opioid.  Examples include acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDS), such as aspirin and ibuprofen.
C2199	Adjuvant_Analgesic	Analgesic_Agent	Adjuvant Analgesic|Adjunctive Analgesics|Adjunctive Medication|Adjuvant Medication	Drugs used in combination with other pain drugs to assist or enhance their action.
C2200	Boron_Delivery_Agent	Pharmacologic_Substance	Boron Delivery Agent|BNCT Agent|Boron Neutron Capture Therapy Agents|Boron Transport Agent	Agents used in Boron Neutron Capture Therapy, a type of radiotherapy, as boron (boron-10) carriers.(NCI)
C2201	mTOR_Inhibitor	Enzyme_Inhibitor	mTOR Inhibitor	Substances that inhibit mTOR, a protein kinase involved in growth related translation and transcription.
C2202	Acetyldinaline	Unclassified_Chemotherapy_Agent	Acetyldinaline|4-(Acetylamino)-N-(2-aminophenyl)benzamide|CI-994|GOE5549|N-acetyl dinaline|N-acetyldinaline|PD 123654	A benzamide derivative being studied for potential antineoplastic activity.  Acetyldinaline inhibits histone deacetylation, leading to inhibition of cell proliferation, induction of differentiation, and apoptosis. (NCI04)
C2203	Acridine_Carboxamide	Intercalating_Agent|Topoisomerase-II_Inhibitor	Acridine Carboxamide|DACA|XR5000|acridine carboxamide	Acridine carboxamide. A substance that is being studied as an anticancer drug. It belongs to the family of drugs called topoisomerase inhibitors.
C2204	Adenovirus_B7-1	Viral_Vector-Gene_Complex	Adenovirus B7-1	A gene-viral vector complex comprised of an adenovirus vector and B7-1 gene targeting the CD80 antigen.  Adenovirus B7-1 is used as a component in antineoplastic vaccines to elicit a cytotoxic T-cell response. (NCI04)
C2205	BCR-ABL_Peptide_Vaccine	Antineoplastic_Vaccine	BCR-ABL Peptide Vaccine|bcr-abl vaccine	A multivalent antineoplastic vaccine comprised of the bcr-abl oncogene breakpoint fusion peptide that elicits a bcr-abl specific T-cell immune response.  (NCI04)
C2206	Biomed_101	Miscellaneous_Chemoprotective_Agent	Biomed 101	A substance that is being studied for its ability to decrease the side effects of interleukin-2 (IL-2).
C2207	Bispecific_Antibody_MDX447	Bispecific_Antibody	Bispecific Antibody MDX447|BsAb MDX447|EMD 82633|MDX-447	An antibody with potential antineoplastic activity. Specific for both the high-affinity immunoglobulin G (IgG) receptor CD64 and epidermal growth factor receptor (EGFR), bispecific antibody MDX447 may enhance cellular immune responses against EGFR positive cells, resulting in increased tumor cell lysis. (NCI04)
C2208	Borocaptate_Sodium	Boron_Delivery_Agent	Borocaptate Sodium|BSH|Borocarpin|Sodium borocaptate	A boron-carrying compound. After parenteral administration, borocaptate sodium accumulates preferentially in tumor cells. When exposed to neutron irradiation, borocaptate absorbs neutrons and self-destructs releasing short-range alpha radiation and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell death. This highly selective, localized radiotargeting of tumor cells, known as boron neutron capture therapy (BNCT), spares adjacent normal tissues. (NCI04)
C2209	Capromab_Pendetide	Monoclonal_Antibody_for_Clinical_Diagnosis	Capromab Pendetide|7E11-C5.3-GYK-DTPA|CYT-356|Prostascint	A monoclonal antibody used in the preparation Indium In 111 Capromab Pendetide as a diagnostic imaging agent for prostate cancer.(NCI)
C2210	CC-1088	Miscellaneous_Angiogenesis_Inhibitor|Phosphodiesterase_Inhibitor	CC-1088	A drug that is similar but not identical to thalidomide and is being studied as an anticancer drug.  It belongs to the family of drugs called angiogenesis inhibitors.
C2211	CRL_1005	Vaccine_Adjuvant	CRL 1005|Tranzfect	A nonionic block copolymer adjuvant used to enhance viral or non-viral polynucleotide delivery in gene therapy vaccines.
C2212	CY-2010	Antineoplastic_Vaccine	MAGE-3 Peptide Vaccine|CY-2010|MAGE-3 Peptide Vaccine (CY-2010)|MAGE-3.1/PADRE-96510|MAGE-3/PADRE-96510	A cancer vaccine consisting of a peptide derived from MAGE-3 and the pan-DR epitope (PADRE), an immunostimulant.  Vaccination with CY-2010 may elicit a cytotoxic T lymphocyte (CTL) immune response against tumor cells expressing MAGE-3. MAGE-is an antigen found on many tumor cell types, including melanoma and lung, prostate, colon, thyroid, and breast cancers. (NCI04)
C2213	Liposomal_Daunorubicin_Citrate	Anthracycline_Antibiotic	Liposomal Daunorubicin Citrate|DaunoXome|DaunoXome (Daunorubicin citrate liposome injection)|Daunorubicin Citrate Liposome|Daunorubicin Citrate Liposome Injection|Daunorubicin Liposomal|Liposomal Daunorubicin	A liposome-encapsulated form of the citrate salt of the anthracycline antineoplastic antibiotic daunorubicin.  Liposomal delivery of doxorubicin citrate improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects.  Daunorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. (NCI04)
C2214	Dendritic_Cell-gp100-MART-1_Antigen_Vaccine	Dendritic_Cell_Tumor_Peptide_Vaccine	Dendritic Cell-gp100-MART-1 Antigen Vaccine|gp100/Mart-1-transduced dendritic cell vaccine	A vaccine comprised of autologous dendritic cells pulsed with Mart-1 (melanoma antigen recognized by T-cells) and gp100 melanoma antigens to elicit T-cell immune response.(NCI)
C2215	HER-2_neu_Intracellular_Domain_Peptide_Vaccine	Antineoplastic_Vaccine	HER-2/neu Intracellular Domain Peptide Vaccine|HER-2/neu Intracellular Domain Protein Vaccine	A vaccine comprised of autologous dendritic cells pulsed with HER2/neu intracellular domain protein to induce a T-cell response.(NCI)
C2216	Imidazole_Mustard	Triazene_Compound	Imidazole Mustard|5-[3, 3-Bis(2-chloroethyl)-1-triazeno]-imidazole-4-carboxamide|5-[3, 3-Bis(2-chloroethyl)-1-triazeno]imidazole-4-carboxamide|5-[3,3-Bis(2-Chloroethyl)-1-Triazeno]Imidazole-4-Carboxamide|BIC|Imidazole mustard|NSC 82196|NSC-82196|TIC Mustard|TIC mustard|TIC-Mustard	A synthetic derivative of imidazole with potent antineoplastic properties.  Imidazole mustard alkylates DNA, preferentially at guanine residues, resulting in DNA interstrand crosslinks and inhibition of DNA replication and RNA and protein synthesis. (NCI04)
C2217	In_111_Monoclonal_Antibody_LL2	Radioimmunoconjugate	In 111 Monoclonal Antibody LL2|In 111 LL2 IgG|Indium In 111 LL2 IgG	A radioimmunoconjugate comprised of LL2, an anti-CD22 pan-B-cell monoclonal antibody, labeled with Indium 111 for use in Radioimmunotherapy as an imaging agent.(NCI)
C2218	In_111_Monoclonal_Antibody_Lym-1	Radioimmunoconjugate	In 111 Monoclonal Antibody Lym-1|In 111 MOAB Lym-1|Indium In 111 MoAb Lym-1|Indium In 111 Monoclonal Antibody Lym-1	A radioimmunoconjugate comprised of Lym-1, a monoclonal antibody that binds to the HLA-DR-encoded histocompatibility antigen, labeled with Indium 111 for use in Radioimmunotherapy as an imaging agent. (NCI)
C2219	In_111_Monoclonal_Antibody_MN-14	Radioimmunoconjugate	In 111 Monoclonal Antibody MN-14|In 111 MOAB MN-14|Indium In 111 MoAb MN-14|Indium In 111 Monoclonal Antibody MN-14	A radioimmunoconjugate comprised of MN-14, an anti-Carcinoembryonic Antigen (CEA) monoclonal antibody, labeled with Indium 111 for use in Radioimmunotherapy as an imaging agent. (NCI)
C2220	Interferon_Alfa-N1	Therapeutic_Interferon_Alfa	Interferon Alfa-N1|Alferon|Humoferon|Interferon Alfa|Wellferon	A highly purified alpha interferon produced by a human lymphoid cell line.  Interferon alpha-n1 consists of multiple alpha interferon subtypes, at least two of which are glycosylated.  In contrast, recombinant alpha interferons are individual non-glycosylated proteins produced from individual alpha interferon genes.  Alpha interferons bind to specific cell-surface receptors, resulting in the transcription and translation of genes whose proteins have antiviral, antiproliferative, anticancer, and immune-modulating effects. (NCI04)
C2221	Interferon_Beta-1B	Therapeutic_Interferon_Beta	Interferon Beta-1B|Beta-ser-interferon|Betaferon|Betaseron|Recombinant interferon beta-1b	A recombinant form of the natural Interferon beta that varies in the amino acid sequence and lacks the carbohydrate side chain. Clinical Use: Multiple Sclerosis.(NCI)
C2222	Interleukin-12_Gene	Transduction_Gene	Interleukin-12 Gene|IL-12 gene	The DNA sequence that encodes the protein cytokine interleukin-12 (IL-12). When introduced as the complementary DNA (cDNA) form into tumor cells by, for example, a genetically engineered adenovirus vector, the transfected IL-12 cDNA expresses IL-12 which activates antitumoral natural killer (NK) cells and CD8+ T-cells and stimulates the secretion of interferon-gamma (IFN-gamma), potentially inhibiting tumor cell metastasis. This gene therapy may also result in IL-12-mediated inhibition of vascular endothelial growth factor (VEGF) and enhancement of matrix metalloproteinases (MMPs). (NCI04)
C2223	I_131_Monoclonal_Antibody_TNT-1_B	Radioimmunoconjugate	I 131 Monoclonal Antibody TNT-1/B|I 131 MOAB TNT-1/B|Iodine I 131 Monoclonal Antibody TNT-1/B|iodine I 131 MOAB TNT-1/B	A radioimmunoconjugate comprised of TNT-1/B, a monoclonal antibody that binds to the necrotic core of tumors, labeled with Iodine 131 for use in Radioimmunotherapy. (NCI)
C2224	Lung_Tumor_Associated_Antigen	Tumor_Antigen	Lung Tumor Associated Antigen|Lung TAA|tumor associated antigen, lung	Tumor associated antigen that is unique to lung cancer.
C2225	Zosuquidar_Trihydrochloride	Multidrug_Resistance_Modulator	Zosuquidar Trihydrochloride|LY335979|Zosuquidar trihydrohloride (LY335979)|zosuquidar trihydrochloride	A difluorocyclopropyl quinoline. Zosuquidar trihydrochloride binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents. (NCI04)
C2226	Lycopene	Carotenoid	Lycopene|LYCOPENE|Lyc-O-Mato|all-trans-Lycopene|lycopene|psi,psi-Carotene	A linear, unsaturated hydrocarbon carotenoid, the major red pigment in fruits such as tomatoes, pink grapefruit, apricots, red oranges, watermelon, rosehips, and guava.  As a class, carotenoids are pigment compounds found in photosynthetic organisms (plants, algae, and some types of fungus), and are chemically characterized by a large polyene chain containing 35-40 carbon atoms; some carotenoid polyene chains are terminated by two 6-carbon rings.  In animals, carotenoids such as lycopene may possess antioxidant properties which may retard ageing and many degenerative diseases.  As an essential nutrient, lycopene is required in the animal diet. (NCI04)
C2227	Monoclonal_Antibody_4B5_Anti-Idiotype_Vaccine	Anti-Idiotype_Vaccine	Monoclonal Antibody 4B5 Anti-Idiotype Vaccine|4B5 monoclonal antibody anti-idiotype vaccine|MoAb 4B5 anti-idiotype vaccine	A vaccine comprised of the monoclonal antibody 4B5, an anti-GD2 anti-idiotypic antibody, mimicking the GD2 antigen, causing an immune response. (NCI)
C2228	Apolizumab	Monoclonal_Antibody	Apolizumab|Apolizumab (Hu1D10)|MoAb Hu1D10|MoAb: Hu1D10|Monoclonal Antibody Hu1D10|Monoclonal antibody 1D10|apolizumab	A humanized monoclonal antibody directed against 1D10, a polymorphic determinant on the HLA-DR beta chain that is expressed on normal and neoplastic B cells. Apolizumab induces complement-mediated cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and apoptosis of 1D10 antigen-positive B cells in vitro.  (NCI04)
C2229	Monoclonal_Antibody_HuM291	Monoclonal_Antibody	Monoclonal Antibody HuM291|Anti CD3|Anti-CD3 Antibody|HUM291 [Anti-CD3 Antibody]|HuM291|MoAb HuM291	A humanized monoclonal antibody deficient in Fc receptor binding directed against CD3 on the surfaces of T cells. Monoclonal antibody HuM291 binds to the CD3 portion of the CD3:TCR (T-cell receptor) complex expressed on the surface of T cells, resulting in apoptosis of antigen-activated T cells., (NCI04)
C2230	Monoclonal_Antibody_M-T412	Monoclonal_Antibody	Monoclonal Antibody M-T412|M-T412|MoAb M-T412	A chimeric murine-human anti-CD4 monoclonal antibody that down regulates T-helper-inducer function. Clinical Trails: Multiple Sclerosis.(NCI)
C2231	MS-209	Multidrug_Resistance_Modulator	MS-209|MS 209	A quinolone derivative that inhibits p-glycoprotein, affecting transmembrane transport and modulating multidrug resistance. (NCI)
C2232	MUC-1_KLH_Vaccine	Antineoplastic_Vaccine	MUC-1 KLH Vaccine|MUC-1-KLH vaccine	A vaccine comprised of MUC-1 protein conjugated with Keyhole Limpet Hemocyanin (KLH) that induces both humoral and cellular responses targeting tumors expressing MUC-1. (NCI)
C2233	Phenethyl_Isothiocyanate	Chemopreventive_Agent	Phenethyl Isothiocyanate|(2-Isothiocyanatoethyl)benzene|2-Phenylethyl Isothiocyanate|PEITC|Phenethyl isothiocyanate|phenethyl isothiocyanate	An isothiocyanate found in cruciferous vegetables and may have chemopreventive properties by inducing apoptosis.
C2234	PNU_166148	Topoisomerase-I_Inhibitor	PNU 166148|MAG-CPT|PNU166148	A polymeric conjugate comprised of Camptothecin, a topoisomerase I inhibitor, covalently conjugated to a copolymer backbone (MAG, methacryloylglycinamide) inducing DNA strand breaks, causing DNA replication inhibition and apoptosis. (NCI)
C2235	PR1_Leukemia_Peptide_Vaccine	Antineoplastic_Vaccine	PR1 Leukemia Peptide Vaccine|leukemia peptide vaccine, PR1|vaccine, PR1 leukemia peptide	A cancer vaccine consisting of PR1, a 9 amino-acid human leukocyte antigen (HLA)-A2 restricted peptide derived from proteinase 3. Vaccination with PR1 leukemia peptide vaccine stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing proteinase 3, resulting in tumor cell lysis. Proteinase 3 is often overexpressed in leukemic cells. (NCI04)
C2236	PSA_RNA-Pulsed_Dendritic_Cell_Vaccine	Dendritic_Cell_Tumor_Peptide_Vaccine	PSA RNA-Pulsed Dendritic Cell Vaccine	A vaccine comprised of autologous dendritic cells pulsed with mRNA-encoded Prostate Specific Antigen (PSA) that elicits PSA specific T-cell response. (NCI)
C2237	Recombinant_Vaccinia-B7_1_Vaccine	Vaccinia_Vaccine	Recombinant Vaccinia-B7.1 Vaccine|RV-B7 (Recomb Vaccinia/B7)|Recombinant Vaccinia-B7.1|rV-B7 (Recomb Vaccinia/B7)|rV-B7.1|rV-B7.1 Vaccine	A recombinant vaccinia virus encoding the T-cell co-stimulatory molecule B7-1. Co-administration of recombinant vaccinia-B7.1 and a tumor-associated antigen in a cancer vaccine may enhance tumor-associated antigen-specific T-cell responses. (NCI04)
C2238	Retrovirus_Vector_LN	Viral_Vector	Retrovirus Vector LN	A viral vector derived from the LN series of replication-defective retroviral vectors.(NCI)
C2239	RevM10_gene-polAS_gene	Transduction_Gene	RevM10 gene/polAS gene	Anti-HIV-1 transduction genes, RevM10 (a dominant negative mutant of the HIV-1 Revtrans-activator protein) and HIV-1 PolAS (an antisense RNA complementary to human HIV-1 pol gene), that have an inhibitory effect on HIV-1 replication in T-cell lines. (NCI)
C2240	AS02A	Vaccine_Adjuvant	AS02A|SBAS-2	An oil-water emulsion comprised of QS21 and 3D-MPL used as a vaccine adjuvant to improve T-helper cells and antibody response. (NCI)
C2241	TG4010	Vaccinia_Vaccine	TG4010|MVA-MUC1-IL2|MVA-MUC1-IL2 Vaccine|Modified Virus of Ankara Encoding Human MUC-1 Antigen and Interleukin-2 Suspension	A substance that is being studied as an anticancer drug.
C2242	Triapine	Ribonucleotide_Reductase_Inhibitor	Triapine|3-AP|3-Aminopyridine-2-carboxaldehyde Thiosemicarbazone|3-aminopyridine-2-carboxaldehyde thiosemicarbazone	3-aminopyridine-2-carboxaldehyde thiosemicarbazone. A substance that is being studied as an anticancer drug. It belongs to the family of drugs called ribonucleotide reductase inhibitors.
C2243	Tumor_necrosis_factor_CET	Therapeutic_Tumor_Necrosis_Factor-Alpha	Tumor Necrosis Factor (CET)	A recombinant form of endogenous Tumor Necrosis Factor alpha manufactured by Cetus Corporation (acquired by Chiron Corporation.  Tumor necrosis factor-alpha binds to and activates receptors on the cell surface, resulting in modulation of adipocyte metabolism, lysis of tumor cells, and induction of hemorrhagic necrosis of certain transplantable tumors. (NCI04)
C2244	Tumor_Necrosis_Factor_Knoll	Therapeutic_Tumor_Necrosis_Factor-Alpha	Tumor Necrosis Factor (Knoll)	A recombinant form of endogenous Tumor Necrosis Factor alpha manufactured by Knoll Pharmaceuticals. Tumor necrosis factor-alpha binds to and activates receptors on the cell surface, resulting in modulation of adipocyte metabolism, lysis of tumor cells, and induction of hemorrhagic necrosis of certain transplantable tumors. (NCI04)
C2245	Tumor_necrosis_factor_GEN	Therapeutic_Tumor_Necrosis_Factor-Alpha	Tumor Necrosis Factor (GEN)	A recombinant form of endogenous Tumor Necrosis Factor alpha manufactured by Genzyme Pharmaceuticals.  Tumor necrosis factor-alpha binds to and activates receptors on the cell surface, resulting in modulation of adipocyte metabolism, lysis of tumor cells, and induction of hemorrhagic necrosis of certain transplantable tumors. (NCI04)
C2246	Tariquidar	Multidrug_Resistance_Modulator	Tariquidar|XR9576	A substance that is being studied for its ability to overcome tumor-cell resistance to anticancer drugs.  It belongs to the family of drugs called anthranilic acid derivatives.
C2247	Y_90_Monoclonal_Antibody_Lym-1	Radioimmunoconjugate	Y 90 Monoclonal Antibody Lym-1|MOAB Lym-1, yttrium Y 90|Y 90 MoAb Lym-1|Yttrium Y 90 Monoclonal Antibody Lym-1|monoclonal antibody Lym-1, yttrium Y 90|yttrium Y 90 MOAB Lym-1	A radioimmunoconjugate comprised of Lym-1, a monoclonal antibody that binds to the HLA-DR-encoded histocompatibility antigen, labeled with Yttrium 90 having a pro-apoptotic effect on tumor cells expressing HLA-DR-encoded histocompatibility antigen. (NCI)
C2248	Y_90_Monoclonal_Antibody_M195	Radioimmunoconjugate	Y 90 Monoclonal Antibody M195|MOAB M195, yttrium Y 90|Y 90 MoAb M195|Yttrium Y 90 Monoclonal Antibody M195|monoclonal antibody M195, yttrium Y 90	A radioimmunoconjugate comprised of M195, a humanized monoclonal antibody reactive with the cell surface antigen CD33, labeled with Yttrium 90 having a pro-apoptotic effect on tumor cells expressing CD33 antigen. (NCI)
C2249	Y_90_Monoclonal_Antibody_MN-14	Radioimmunoconjugate	Y 90 Monoclonal Antibody MN-14|MOAB MN-14, yttrium Y 90|Y 90 MoAb MN-14|Yttrium Y 90 Monoclonal Antibody MN-14|monoclonal antibody MN-14, yttrium Y 90|yttrium Y 90 MOAB MN-14	A radioimmunotherapeutic monoclonal antibody (MN-14) directed against tumor-associated carcinoembryonic antigen (CEA) and chelated to the radioisotope yttrium-90 (Y 90). Y 90 monoclonal antibody MN-14 binds to tumor cell expressing CEA, delivering a cytotoxic dose of beta radiation. (NCI04)
C2250	_10-Propargyl-10-Deazaaminopterin	Folate_Antagonist	10-Propargyl-10-Deazaaminopterin|10-propargyl-10-deazaaminopterin	A substance that is being studied as an anticancer drug.  It belongs to the family of drugs called folate analogues.
C2251	Therapeutic_Platelet_Factor_4	Miscellaneous_Angiogenesis_Inhibitor|Therapeutic_Alpha_Chemokine	Recombinant Platelet Factor 4|CXCL4|Platelet Factor 4|rPF4|rhPF4	A recombinant form of the endogenous chemokine platelet factor 4 with potential antineoplastic activity.  As a heparin-binding tetramer, recombinant platelet factor 4 inhibits growth factor-stimulated endothelial cell proliferation, migration, and angiogenesis.  This agent may also directly inhibit the proliferation of some tumor cell types. (NCI04)
C2252	Chemotherapeutic_Topical_Agent	Antineoplastic_Agent	Chemotherapeutic Topical Agent	Topical Agents that exhibit cytotoxic activity.(NCI)
C2253	DNA_Repair_Enzyme_Topical_Agent	Chemotherapeutic_Topical_Agent	DNA Repair Enzyme Topical Agent	A topical agent containing a DNA repair enzyme.(NCI)
C2254	Amidophosphoribosyltransferase_Inhibitor	Enzyme_Inhibitor	Amidophosphoribosyltransferase Inhibitor	Substances that inhibit Amidophosphoribosyltransferase, an enzyme involved with purine synthesis, interfering with de novo purine synthesis, causing inhibition of DNA synthesis.(NCI)
C2255	Estrogen_Sulfotransferase_Inhibitor	Enzyme_Inhibitor	Estrogen Sulfotransferase Inhibitor	Substances that inhibit Estrogen Sulfotransferase, an enzyme that catalyzes the sulfoconjugation of estrogen, modulating systemic and local estrogen response.(NCI)
C2256	Therapeutic_Delta_Chemokine	Therapeutic_Chemokine	Recombinant Delta Chemokine|CX3C|CX3C Chemokines|Delta Chemokines	Recombinant form of endogenous delta-chemokine family.(NCI)
C2257	Therapeutic_Fractalkine	Therapeutic_Delta_Chemokine	Recombinant Fractalkine|CX3CL1|Fractalkine|Neurotactin	A pro-inflammatory delta chemokine with potential antineoplastic activity.  Fractalkine induces the adhesion and migration of T lymphocytes, monocytes and natural killer (NK) cells.  In lymphomas, this agent may promote cell-mediated lympholysis by recruiting activated NK cells. (NCI04)
C2258	Angiotropin_Recombinant	Retired_Concepts	Angiotropin (Recombinant)
C2259	Therapeutic_Neurotrophic_Factor	Therapeutic_Growth_Factor	Recombinant Neurotrophic Factor|Neurotrophic Factor|Recombinant Neurotrophins	Recombinant form of endogenous neurotrophic factors, a family of polypeptide growth factors produced by peripheral target tissues as well as the nervous system.  Neurotrophic factors are critical to neuronal growth, regeneration, survival, and differentiation. (NCI)
C2260	Therapeutic_Neuropoietic_Cytokines	Therapeutic_Neurotrophic_Factor	Recombinant Neuropoietic Cytokines	Recombinant forms of endogenous neuropoietic cytokines.(NCI)
C2261	Therapeutic_Heparin-Binding_Neurotrophic_Factor	Therapeutic_Growth_Factor	Recombinant Heparin-Binding Neurotrophic Factor	Recombinant forms of endogenous Heparin-binding Neurotrophic factors(NCI)
C2262	Recombinant_IGF-I	Therapeutic_Insulin-Like_Growth_Factor	Recombinant IGF-I|Mecasermin|Myotrophin|Recombinant Insulin-Like Growth Factor 1|rhIGF-1	Recombinant form of endogenous Insulin-like Growth Factor 1 exhibiting mitogenic activity.  Clinical Use: Diabetes Mellitus and Amyotrophic Lateral Sclerosis.(NCI)
C2263	Recombinant_IGF-II	Therapeutic_Insulin-Like_Growth_Factor	Recombinant IGF-II	Recombinant form of endogenous Insulin-like Growth Factor II exhibiting mitogenic activity.(NCI)
C2264	Adrenal_Hormone	Steroid_Hormone	Adrenal Hormone|Adrenal	Hormones made from cholesterol and protein produced by the adrenal glands and regulate electrolyte balance, blood pressure, inflammation, blood sugar balance, and immune system control.(NCI)
C2265	Therapeutic_Dehydroepiandrosterone	Therapeutic_Androgen	Therapeutic Dehydroepiandrosterone|3beta-Hydroxyandrost-5-en-17-one|DHEA|Dehydroepiandrosterone|Dehydroisoandrosterone|Fidelin|GL701|Prasterone|dehydroepiandrosterone	A substance that is being studied as a cancer prevention drug. It belongs to the family of drugs called steroids.
C2266	Recombinant_Thymopoietin	Miscellaneous_Hormone_Agent	Recombinant Thymopoietin	Recombinant form of endogenous thymopoietin, a thymic hormone.(NCI)
C2267	Melatonin	Hormone	Melatonin|N-[2-(5-Methoxy-1H-indol-3-yl)ethyl]acetamide
C2268	Glucagon	Peptide_Hormone	Glucagon|Antidiabetic Hormone|GCG|HG-Factor|Hyperglycemic Glycogenolytic Factor	A pancreatic hormone consisting of 29 amino acids that causes increases in blood sugar levels by stimulating hepatic glycogenolysis and gluconeogenesis.
C2269	Corticotropin_Releasing_Hormone	Hypothalmic_Hormone	Corticotropin Releasing Hormone|CRF|CRH|Corticotropin Releasing Factor	A hormone synthesized in the hypothalamus and regulates the secretion of adrenocorticotropic hormone (ACTH).(NCI)
C2270	Gonadotrophin_Releasing_Hormone	Hypothalmic_Hormone	Gonadotrophin Releasing Hormone|AY-24031|D-His-6-Pro-8-NEt-LHRH|Follicle Stimulating Hormone-Releasing Factor|GN-RH|GnRH|Gonadoliberin|Gonadorelin|Gonadorelinum|Hoe- 471|LH-RF|LH-RH|LH/FSH-RF|LH/FSH-RH|Luliberin|Luteinising Hormone-Releasing Factor|Luteinizing Hormone-Releasing Factor|Luteinizing Hormone-Releasing Hormone|luteinizing hormone-releasing hormone	LH-RH.  A hormone that stimulates the production of sex hormones in men and women.
C2271	Insulin	Peptide_Hormone	Insulin|insulin	Human insulin protein (110 aa, 12 kDa) is encoded by the human insulin (INS) gene. This cytosolic protein, a heterodimer of disulfide-linked alpha and beta chains, is produced in pancreatic islet beta cells. Binding of insulin to its receptor stimulates glucose uptake, accelerates both glycolysis and the pentose phosphate cycle and increases glycogen synthesis in the liver. Insulin regulates protein and lipid metabolism. It also decreases blood glucose concentration by shuttling molecules into cells to be used for energy. Decreased expression of insulin protein causes familial hyperproinsulinemia.
C2272	Gastrin_Releasing_Peptide	Peptide_Hormone	Gastrin Releasing Peptide|GRP|Mammalian Bombesin	Gastrin-releasing peptide (GRP) is the equivalent in mammals of the amphibian bombesin. Infusion of either GRP or bombesin increases plasma levels of gastrin, pancreatic polypeptide, glucagon, gastric inhibitory peptide, and insulin. It is widely distributed in the gastrointestinal tract and in the nervous system.  In normal adult mammal GRP is strictly a neuropeptides and functions in a neurotransmitter-like fashion. In the fetus, a larger form of GRP acts as a hormone and exerts growth factor-like activity on many organs, aiding in development.
C2273	Gonadotropin	Peptide_Hormone	Gonadotropin	Heterodimeric glycoprotein Gonadotropin consists of alpha (common)/beta (unique) protein subunits. The alpha subunit is present in other heterodimeric glycoprotein hormones. The beta subunit confers biological specificity and stimulates ovarian synthesis of steroids (progesterone) to maintain pregnancy.
C2274	Human_Menopausal_Gonadotropin	Gonadotropin	Human Menopausal Gonadotropin|HMG|Menotropins	Follicle-Stimulating Hormone and Luteinizing Hormone excreted in the urine of post-menopausal women.(NCI)
C2275	Human_Chorionic_Gonadotropin	Protein_or_Riboprotein_Complex	Human Chorionic Gonadotropin|Gonadotropin, Chorionic|LDI-200|hCG	A sialoglycoprotein hormone secreted by the placenta and maintains the corpus luteum at the beginning of the gestation period.(NCI)
C2276	Inhibin	Protein_or_Riboprotein_Complex	Inhibin|Folliculostatin|Inhibin Hormone	Inhibins are peptide hormones, secreted by the follicular cells of the ovary and by the testis, that negatively regulate the synthesis and secretion of follicle stimulating hormone from the anterior pituitary.  The detection of serum inhibins has been implicated in association with reproductive disorders, including infertility and ovarian cancers.
C2277	Inhibin-A	Inhibin	Inhibin A	Both inhibin A and inhibin B are heterodimers consisting of an alpha subunit and a beta A or beta B subunit linked by disulphide bonds.  Both inhibins function as negative regulators for FSH synthesis and secretion.  Furthermore, serum concentrations of inhibins transit from inhibin B to inhibin A dominance during menstrual cycle.
C2278	Inhibin-B	Inhibin	Inhibin B|Inhibin Beta	Inhibin B, consisting of an alpha subunit and a beta B subunit linked by disulphide bonds, is a heterodimer hormone produced by the follicle cells of the ovary and by the Sertoli and Ledig cells of testis.  Although other forms of inhibin also exist in men, inhibin B is the predominant form in the circulation in men.
C2279	Prothymosin_Alpha	Immunoprotein	Prothymosin Alpha|PTMA	Encoded by human PTMA Gene, 110-aa 12-kDa (precursor) highly acidic (54/111 residues) conserved Prothymosin Alpha may be linked covalently to a small RNA; may be involved in ultraviolet irradiation-induced apoptosis; contains N-terminal thymosin-alpha-1 (28-aa) sequence; and may mediate immune function and confer resistance to opportunistic infections. While PHAP promotes caspase-9 activation after apoptosome formation, PTMA inhibits apoptosome formation and caspase-9 activation; caspase-3 activator PETCM relieves PTMA inhibition of apoptosome formation. (NCI)
C2280	Thyroid_Stimulating_Hormone	Protein_or_Riboprotein_Complex	Thyroid Stimulating Hormone|TSH|Thyreotropin|Thyrotropin	A peptide hormone secreted by the anterior pituitary. It promotes the growth of the thyroid gland and stimulates the synthesis of thyroid hormones and the release of thyroxine by the thyroid gland.
C2281	Calcitonin	Peptide_Hormone	Calcitonin|Thyrocalcitonin	Encoded by human CALCA Gene (Calcitonin Family), 32-aa 3.4-kD secreted Calcitonin polypeptide hormone is cleaved from a large polyprotein precursor synthesized by thyroid parafollicular 'C' cells. Opposite to the effect of PTH, Calcitonin induces a rapid drop in blood calcium and phosphate level by promoting bone incorporation. (NCI)
C2282	Adrenocorticotropic_Hormone	Pituitary_Hormone	Adrenocorticotropic Hormone|ACTH|Adrenocorticotropin|Corticotropin	A hormone secreted by the anterior portion of the pituitary gland and regulates hormone, primarily cortisol, secreted by the adrenal gland.(NCI)
C2283	Oxytocin	Pituitary_Hormone	Oxytocin|OXT	A hormone secreted by the posterior portion of the pituitary gland and stimulates uterine smooth muscle contraction and lactation.(NCI)
C2284	Thymosin	Peptide_Hormone	Thymosin	A hormone secreted by the thymus gland and effects T-lymphocyte differentiation and activation.(NCI)
C2285	Vasopressin	Pituitary_Hormone	Vasopressin|ADH|AVP|Antidiuretic Hormone|Arginine Vasopressin	This protein is processed from a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin II and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin II, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. (LocusLink)
C2286	Follicle_Stimulating_Hormone	Protein_or_Riboprotein_Complex	Follicle Stimulating Hormone|FSH|Follicle-Stimulating Hormone|Follitropin	A gonadotropin hormone synthesized by the anterior lobe of the pituitary and is essential for reproduction, stimulating estrogen and sperm production.(NCI)
C2287	Luteinizing_Hormone	Protein_or_Riboprotein_Complex	Luteinizing Hormone|Interstitial Cell-Stimulating Hormone|LH|Lutropin|Pituitary Lutenizing Hormone	A gonadotropin hormone synthesized by the anterior lobe of the pituitary that stimulates synthesis and secretion of testosterone and estrogen, and ovulation of mature follicles on the ovary.(NCI)
C2288	Growth_Hormone	Pituitary_Hormone	Growth Hormone|GH|GHN|Growth Hormone 1|Pituitary Growth Hormone|Somatotropic Hormone|Somatotropin|hGHN	A peptide hormone secreted by the anterior lobe of the pituitary gland and regulates several physiologic processes, including growth and metabolism.(NCI)
C2289	Steroid_Hormone	Hormone|Steroid_Compound	Steroid Hormone	Hormones possessing the steroid ring system; e.g., androgens, estrogens, adrenocortical hormones.
C2290	Cortisol	Glucocorticoid	Cortisol|(11beta)-11,17,21-Trihydroxypregn-4-ene-3,20-dione|Hydrocortisone
C2291	Cortisone	Glucocorticoid	Cortisone|17,21-Dihydroxypregn-4-ene-3,11,20-trione	A natural steroid hormone produced in the adrenal gland. It can also be made in the laboratory.  Cortisone reduces swelling and can suppress immune responses.
C2292	Epinephrine	Neurotransmitter	Epinephrine|Adrenaline	A hormone and neurotransmitter. Also called adrenaline.
C2293	Estrogen	Steroid_Hormone	Estrogen
C2294	Estrone	Estrogen	Estrone|1,3,5(10)-Estratrien-3-ol-17-one|3-Hydroxyestra-1,3,5(10)-trien-17-one	One of three naturally occuring estrogens synthesized from androstenedione in the adrenal glands and peripheral tissues by aromatization and is the primary estrogen produced after menopause.(NCI)
C2295	Estradiol	Estrogen	Estradiol|(17beta)-Estra-1,3,5(10)-triene-3,17-diol|17 Beta-Estradiol|17-beta-Estradiol	Estradiol (E2). beta-estradiol; 17 beta-estradiol; 1,3,5(10)-estratriene-3,17 beta-diol; the most potent naturally occurring estrogen in mammals, formed by the ovary, placenta, testis, and possibly the adrenal cortex; therapeutic indications for estradiol are those typical of an estrogen. alpha-Estradiol, (17 alpha-estradiol), exhibits considerably less biologic activity. Estradiol is used in the treatment of menstrual disorders, menopause problems, etc. SYN estrogenic hormone, oestradiol.
C2296	Progestagen	Steroid_Hormone	Progestagen|Progestational Hormones|Progestogens	A hormone secreted in the uterus controlling ovum implantation.
C2297	Progesterone	Progestagen	Progesterone|Corpus Luteum Hormone|Delta4-pregnene-3,20-dione|Pregn-4-ene-3,20-dione|progesterone	(pro-JES-ter-own) A female hormone.
C2298	Androgen	Steroid_Hormone	Androgen	(AN-dro-jens) A family of hormones that promote the development and maintenance of male sex characteristics.
C2299	Testosterone	Androgen	Testosterone|(17Beta)-17-hydroxyandrost-4-en-3-one|Delta4-androsten-17beta-ol-3-one|Trans-Testosterone|testosterone	(tes-TOS-ter-own) A hormone that promotes the development and maintenance of male sex characteristics.
C2300	Androstenedione	Anabolic_Steroid	Androstenedione|4-Androstene-3,17-dione|Androst-4-ene-3,17-dione|Delta-4-Androstenedione|delta4-Androstene-3,17-dione	A steroid hormone synthesized by the adrenal glands and the gonads from either 17-alpha-hydroxyprogesterone or dehydroepiandrosterone and is a precursor of testosterone.(NCI)
C2301	Testolactone	Steroidal_Aromatase_Inhibitor	Testolactone|1,2,3,4,4a,4b,7,9,10,10a-Decahydro-2-hydroxy-2,4b-dimethyl-7-oxo-1-phenanthrenepropionic Acid Delta-Lactone|1-Dehydrotestololactone|13-Hydroxy-3-0x0-13,17-secoandrosta-1,4-dien-17-oic Acid Delta-Lactone|17Alpha-oxo-D-homo-1,4-androstadiene-3,17-dione|D-Homo-17a-oxaandrosta-1,4-diene-3,17-dione|Delta-1-Testololactone|Fludestrin|SQ 9538|SQ-9538|TESTOLACTONE|Teslac|Therapeutic Testolactone	A progesterone derivative with antineoplastic activity. Testolactone inhibits steroid aromatase, thereby preventing the formation of estrogen from adrenal androstenedione and reducing endogenous estrogen levels. (NCI04)
C2302	Thyroxine	Thyroid_Hormone	Thyroxine|L-Thyroxine|Levothyroxine|T4	A hormone synthesized and secreted by the thyroid gland containing four iodine atoms and is converted to triiodothyronine (T3) in the body, influencing metabolism and organ function.(NCI)
C2303	Triiodothyronine	Thyroid_Hormone	Triiodothyronine|3,3',5-triiodo-L-thyronine|Liothyronine|T-3|T3	A thyroid hormone containing 3 iodine atoms generally synthesized from levothyroxine, and has greater biological activity.(NCI)
C2304	Thyroglobulin	Structural_Protein	Thyroglobulin|TG	(THIGH-roe-GLOB-yu-lin)
C2305	WT1-Ricin_A_Immunotoxin	Ricin_Immunoconjugate	WT1-Ricin A Immunotoxin|WT-1 Ricin A	An anti-CD7 immunotoxin comprised of the monoclonal antibody WT1 and the ricin-a chain toxin, causing decreased T-lymphocyte production, natural killer cell activity, and protein synthesis.(NCI)
C2306	Ad5CMV	Adenovirus_Vector	Ad5CMV	A recombinant replication-deficient serotype 5 adenovirus. Containing an expression cassette consisting of the human cytomegalovirus (CMV) promoter and the simian virus 40 (SV40) polyadenylation signal, Ad5CMV is used as a transfer vector for inserting genes of interest into target cells for expression. (NCI04)
C2307	Adenovirus_Agent	Retired_Concepts	Adenovirus Agent|Adenoviral Agent
C2308	Improsulfan	Alkylsulfonate_Compound	Improsulfan|Improsulfan tosylate|improsulfan tosilate	An alkylsulfonate alkylating agent that cross-links with DNA, causing inhibition of DNA synthesis.(NCI)
C2309	Glutaminase-Asparaginase	Miscellaneous_Chemoprotective_Agent	Glutaminase-Asparaginase	Glutamine and Asparagine depleting enzyme belonging to the family of tetrameric bacterial amidohydrolases and have antitumor activity. (NCI)
C2310	PEG-Glutaminase-Asparaginase	Miscellaneous_Chemoprotective_Agent|Protein_Synthesis_Inhibitor	PEG-Glutaminase-Asparaginase|PEG-L-glutaminase-L-asparaginase|Polyethylene Glycol-Glutaminase-Asparaginase|polyethyleneglycol-L-glutaminase-L-asparaginase	A pegylated form of glutaminase-asparaginase developed to decrease immunogenicity.(NCI)
C2311	Bleomycin_Antibiotic	Antineoplastic_Antibiotic|Intercalating_Agent	Bleomycin Antibiotic|Bleomycins	A class of basic glycopeptide antineoplastic antibiotics isolated from the fungus Streptomyces verticillus.  Bleomycin antibiotics form complexes with iron that reduce molecular oxygen to superoxide (O2-) and hydroxyl radicals which cause single- and double-stranded breaks in DNA; these reactive oxygen species also induce lipid peroxidation, carbohydrate oxidation, and alterations in prostaglandin synthesis and degradation.  (NCI04)
C2312	ALVAC	Canarypox_Vectors	ALVAC|ALVAC Canarypox Vector	A derivative of the Canarypox Virus, ALVAC can infect mammalian cells but it can't replicate.  Thus, it produces a self-limiting infection which does not produce symptoms or harm the host.  When carrying foreign genes it will cause transient expression of protein.
C2313	Vaccinia_Vaccine	Antineoplastic_Vaccine	Vaccinia Vaccine	A class of antineoplastic vaccines containing the vaccinia virus, originally used for immunization against smallpox, as a viral vector and immunogenic substance.(NCI)
C2314	Anti-Gastrin_Therapeutic_Vaccine	Antineoplastic_Vaccine	Anti-Gastrin Therapeutic Vaccine|Neutralize Hormone G17|Neutralizing G17 Hormone	An immunotoxin composed of the hormone gastrin linked to diptheria toxin.  It is in phase 3 trials for the treatment of pancreatic cancer.
C2315	Hormone	Physiology-Regulatory_Factor	Hormone|Endocrine Gland Secretion|Hormones|hormones	Chemicals produced by glands in the body and circulated in the bloodstream. Hormones control the actions of certain cells or organs.
C2316	Miscellaneous_Adjuvant	Adjuvant	Miscellaneous Adjuvant	Adjuvant agents with non-specific classifications.(NCI)
C2317	Dietary_Lipid	Dietary_Component	Dietary Lipid	A class of food constituents, also known as fats and oils, that serve as a source of energy and essential fatty acids in animals. The major components of lipids are fatty acids, triglycerides, phospholipids, glycolipids, sphingolipids, steroids (cholesterol), and lipoproteins.(NCI)
C2318	Shark_Cartilage	Nutritional_Supplement	Shark Cartilage|BeneFin|BeneFin (Lane Shark Cartilage Powder)|Cartilade	A nutritional supplement gleaned from the exoskeleton of the shark. Shark cartilage inhibits metalloproteinases (MMPs) and possesses antiangiogenic and antimetastatic properties. (NCI04)
C2319	_5_Alpha-Reductase_Inhibitor	Enzyme_Inhibitor	5 Alpha-Reductase Inhibitor	Substances that inhibit 5-alpha-Reductase, an enzyme that metabolizes testosterone to dihydrotestosterone, and can reduce prostate size.
C2320	Teroxirone	Epoxide_Compound	Teroxirone|Henkel's Compound|alpha-1,3,5-triglycidyl-s-triazinetrione|alpha-TGI|alpha-Triglycidyl Isocyanurate	A triazene triepoxide with antineoplastic activity. Teroxine alkylates and cross-links DNA, thereby inhibiting DNA replication. (NCI04)
C2321	Norepinephrine	Adrenal_Hormone|Neurotransmitter	Norepinephrine|(.+-.)-Noradrenaline|(.+-.)-Norepinephrine|(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol|Arterenol|Noradrenaline	A catecholamine hormone that functions as a neurotransmitter in the sympathetic nervous system, producing alpha-adrenergic (vasoconstriction) and beta(1)-adrenergic stimulation (increase myocardial contractility, heart rate, automaticity, and AV conduction), and beta(2)-adrenergic activity (peripheral vasodilation).(NCI)
C2322	Corticosteroid	Adrenal_Hormone	Corticosteroid	Hormones synthesized in the cortex of the adrenal gland and consist of two subclasses, glucocorticoids (carbohydrate regulation) and mineralocorticoids (electrolyte regulation).(NCI)
C2323	Glucocorticoid	Corticosteroid	Glucocorticoid	A group of corticosteroids that affect carbohydrate metabolism (gluconeogenesis, liver glycogen deposition, elevation of blood sugar), inhibit corticotropin secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system. (MSH2002_06_01)
C2324	Mineralocorticoid	Corticosteroid	Mineralocorticoid	A class of corticosteroid hormones that maintains fluid and electrolyte balance. The main mineralocorticoid is Aldosterone.(NCI)
C2325	Therapeutic_Beta_Thromboglobulin	Therapeutic_Alpha_Chemokine	Recombinant Beta Thromboglobulin|Beta TG	A therapeutic analogue of an endogenous, platelet-specific protein that is a member of the alpha chemokine family.  Beta thromboglobulin may be used as a marker for platelet activation. (NCI04)
C2326	Recombinant_Fibroblast_Growth_Factor_7	Therapeutic_Fibroblast_Growth_Factor	Recombinant Fibroblast Growth Factor 7|FGF-7	A recombinant therapeutic agent which is chemically identical to or similar to endogenous fibroblast growth factor 7 (FGF-7). Because it stimulates proliferation and differentiation in parenchymal epithelial cells of differentiated tissues, recombinant FGF-7 may be useful in the treatment of wounds and pathologies associated with dermal adnexae, liver, lungs and the gastrointestinal tract. (NCI04)
C2327	Niacinamide	Niacin	Niacinamide|3-Pyridinecarboxamide|NIACINAMIDE|Nicamid|Nicosedine|Nicotinamide|Nicotinamidum|Nicotinic Acid Amide|Nicotinic acid amide|Nicotylamide|Pellagra-Preventing Factor|Vitamin PP|niacinamide|nicotinamide	A vitamin being studied to increase the effect of radiation therapy on tumor cells.
C2328	Cefotaxime_Sodium	Cefotaxime	Cefotaxime Sodium|CEFOTAXIME SODIUM|Mefoxin	The sodium salt form of cefotaxime.  Cefotaxime inhibits mucopeptide synthesis by binding to penicillin binding proteins, causing inhibition of bacterial cell wall synthesis. (NCI)
C2329	HB2-Saporin_Immunotoxin	Anti-CD7_Immunotoxin	HB2-Saporin Immunotoxin|HB2(anti-CD7) saporin immunotoxin	An immunotoxin comprised of an anti-CD7 antibody, HB-2, linked to Saporin, a toxin that inhibits protein synthesis, eliciting an antibody-dependent cellular immunity response. (NCI)
C2330	Anti-CD19_Immunotoxins	Immunotoxin	Anti-CD19 Immunotoxins	A class of immunotoxins targeting CD19, a common B-cell marker.(NCI)
C2331	B43-PAP_Immunotoxin	Anti-CD19_Immunotoxins	B43-PAP Immunotoxin|B43-PAP|B43-Pokeweed Antiviral Protein Immunotoxin	An immunotoxin comprised of a ribosome inhibitory plant toxin, Pokeweed Antiviral Protein (PAP), conjugated with a murine IgG1 anti-CD19 monoclonal antibody selectively targeting B-lineage progenitor cells, causing apoptosis. (NCI)
C2332	B43_Immunotoxin	Anti-CD19_Immunotoxins	B43 Immunotoxin
C2333	Anti-CD33_Immunotoxin	Immunotoxin	Anti-CD33 Immunotoxin
C2334	Di-dgA-RFB4_Immunotoxin	Ricin_Immunoconjugate	Di-dgA-RFB4 Immunotoxin|Di-dgA-RFB4|Di-dgA-RFB4 Monoclonal Antibody|Monoclonal Antibody Di-dgA-RFB4|di-dgA-RFB4 monoclonal antibody	An anticancer drug that is a combination of a monoclonal antibody (RFB4) and an immunotoxin (dgA).
C2335	IgG-RFB4-SMPT-dgA_Immunotoxin	Ricin_Immunoconjugate	IgG-RFB4-SMPT-dgA Immunotoxin|IgG-RFB4-SMPT-dgA	An immunotoxin comprised of a SMPT stabilized anti-CD22 murine monoclonal antibody, RFB4, linked with a deglycosylated A chain of ricin, a toxin, selectively targeting and poisoning CD22 expressing tumor cells.
C2336	Raf_Kinase_Inhibitor	Protein_Kinase_Inhibitor|Signal_Transduction_Inhibitor	Raf Kinase Inhibitor	Substances that inhibit Raf Kinase, an enzyme active in signal transduction of the Ras pathway, and may prevent tumor formation.(NCI)
C2337	Sodium_Butyrate	Differentiation_Inducer|Histone_Deacetylase_Inhibitor	Sodium Butyrate|Butyrate|Butyrate sodium|Butyric Acid, Sodium Salt|Sodium butanoate|Sodium butyrate|butyric acid, sodium salt|sodium butanoate	A histone deacetylase inhibitor that induces cell differentiation and apoptosis.(NCI)
C2338	Imipenem-Cilastatin_Sodium	Beta-Lactam_Antibiotic	Imipenem-Cilastatin Sodium|Imipenem Cilastatin Sodium|Imipenem/Cilastatin|Primaxin	A combination antibiotic containing Imipenem, a broad spectrum beta-lactam antibiotic, and Cilastatin Sodium, an agent that reduces metabolism of Imipenem by inhibiting dehydropeptidase, used in treating severe infections caused by multiresistant organisms.(NCI)
C2339	BCG_Cell_Wall_Skeleton	BCG	BCG, Cell Wall Skeleton	A mycobacterial cell wall material and serves as an immunoadjuvant that induces both cell-mediated and humoral immunity.(NCI)
C2340	Combid	Cough_and_Cold_Preparation	Combid|Prochlor-Iso|Prochlorperazine Maleate and Isopropamide Iodide	A discontinued (U.S.) brand name combination product containing Prochlorperazine Maleate and Isopropamide Iodide that was used as an antiemetic agent.(NCI)
C2341	Tumor_Cell_Derivative_Vaccine	Antineoplastic_Vaccine	Tumor Cell Derivative Vaccine|tumor antigen vaccine	A vaccine made of tumor antigens (proteins isolated from tumor cells).
C2342	Recombinant_Soluble_Human_CD4_Protein	Miscellaneous_Antiviral_Agent	Recombinant Soluble Human CD4 Protein|rCD4|rCD4/IgG	A genetically engineered agent that is capable of binding to the HIV envelope protein (gp120) and may reduce the ability of HIV to enter the cell and reproduce. (NCI)
C2343	Flurocitabine	Pyrimidine_Antagonist	Flurocitabine|AAFC|Cyclo Cytidine, 5-Fluoro-, Hydrochloride|Cyclo cytidine, 5-fluoro-, hydrochloride	A Cytosine Arabinoside derivative that inhibits pyrimidine synthesis, causing inhibition of DNA synthesis. (NCI)
C2344	Camptothecin_Sodium	Camptothecin	Camptothecin Sodium|Camptothecin Sodium Salt|Camptothecin sodium|Camptothecin, sodium salt|Sodium camptothecin	The sodium salt of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, with antineoplastic activity.  During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. The sodium salt of camptothecin is more water-soluble than the parent molecule. (NCI04)
C2347	Freunds_Adjuvant	Vaccine_Adjuvant	Freund's Adjuvant|Complete Freund's Adjuvant|FCA|Freund's Complete Adjuvant
C2348	Pituitary_Agent	Therapeutic_Hormone	Pituitary Agent	Recombinant forms of the naturally occuring hormones synthesized by the pituitary gland.(NCI)
C2349	Monoclonal_Antibody_R24	Monoclonal_Antibody	Monoclonal Antibody R24|MoAb R24|R-24 Monoclonal Antibody|R24	An IgG murine monoclonal antibody directed against the ganglioside GD3 glycolipid, located in the cell membranes of some tumor cells.  Monoclonal antibody R24 binds to GD3-positive cells, thereby initiating antibody-dependent cytotoxicity against GD3-positive cells. (NCI04)
C2350	Ovine_Submaxillary_Mucin	Miscellaneous_Biologic_Response_Modifier	Ovine Submaxillary Mucin|Ovine Sialomucin	Glycoproteins contained in epithelial mucous secretions that express Sialyl Tn obtained from Ovine submaxillary glands and may be used in Vaccine Therapy. (NCI)
C2351	Hyperbaric_Oxygen	Radiosensitizing_Agent	Hyperbaric Oxygen|hyperbaric oxygen	Oxygen that is administered at a higher pressure compared to standard (i.e. sea-level) atmospheric pressure.  Administration of oxygen under hyperbaric conditions enhances the delivery of oxygen to hypoxic tumor cells, thereby increasing their sensitivity to radiation and chemotherapy.  In addition, hyperbaric oxygen may improve the healing of radiation-induced injuries by improving oxygen delivery to damaged tissue. (NCI04)
C2352	Methylmercaptopurine_Riboside	Purine_Antagonist	Methylmercaptopurine Riboside|6-(methylmercapto)purine ribonucleoside|6-(methylthio) inosine|6-(methylthio)purine ribonucleoside|6-(methylthio)purine riboside|6-MMPR|6-MP Riboside|6-methyl MP riboside|6-methylmercaptopurine riboside|6-methylthioinosine|6MMPR|9H-Purine, 6-(methylthio)-9-.beta.-D-ribofuranosyl- (8CI 9CI)|9H-Purine, 6-(methylthio)-9-.beta.-D-ribofuranosyl-, dihydrate|9H-purine, 6-(methylthio)-9-beta-D-ribofuranosyl- (8CI 9CI)|9H-purine, 6-(methylthio)-9-beta-D-ribofuranosyl-, dihydrate|9H-purine, 6-(methylthio)-9beta-D-ribofuranosyl|MMPR|NCI-C04784|SQ 21977|beta-D-ribosyl-6-methylthiopurine|methylthioinosine|purine-6-thiol,6-methyl-9-ribofuranosyl	A purine derivative with antineoplastic and anti-angiogenic properties.  6-methylmercaptopurine riboside (6-MMPR) inhibits amidophosphoribosyltransferase, the first committed step in de novo purine synthesis, and inhibits fibroblast growth factor-2 (FGF2)-induced cell proliferation. (NCI04)
C2353	PALA_Disodium	N-Phosphonacetyl-L-aspartate	PALA Disodium	The disodium salt form of N-phosphonacetyl-L-aspartate (PALA), a pyrimidine antimetabolite with antineoplastic activity.  PALA inhibits pyrimidine biosynthesis and increases the extent to which fluorouracil is incorporated into RNA. (NCI04)
C2354	Thiazolidine_Carboxylic_Acid	Bombesin_Antagonist	Thiazolidine Carboxylic Acid|4-Thiazolidine Carboxylic Acid|4-Thiazolidinecarboxylic Acid|ATC|Detoxepa|Hepalidine|Heparegen|Thiaproline|Thiazolidine-4-carboxylic Acid|Thiazolidine-4-carboxylic acid|Thiazolidinecarboxylic Acid|Thioproline|Tiazolidin|Timonacic	A natural liver metabolite and antioxidant.
C2355	Anti-Adrenal	Hormone_Antagonist	Anti-Adrenal|Adrenocortical Suppressant|Antiadrenal Agent	Substances that inhibit the biologic effects of the adrenal hormones by interfering with their synthesis, metabolism, or binding to their receptor sites.(NCI)
C2356	Analgesic_and_Antipyretic	Nonnarcotic_Analgesic	Analgesic and Antipyretic	Nonnarcotic agents that relieve pain and reduce fever.(NCI)
C2357	I_131_Antiferritin_Immunoglobulin	Radioimmunoconjugate	I 131 Antiferritin Immunoglobulin|I 131-AFI|I 131-antiferritin IgG|Iodine I 131 Antiferritin Immunoglobulin|immunoglobulin, iodine I 131 antiferritin	A radioimmunoconjugate comprised of antibodies to ferritin, expressed by hepatocellular carcinoma, and labeled with Iodine 131. (NCI)
C2358	Monoclonal_Antibody_T101	Monoclonal_Antibody	Monoclonal Antibody T101|Antibody T-101, Monoclonal|MA T101 Human T-Lymphocyte|MoAb T-101|MoAb T101|Monoclonal Antibody T-101|T-101 monoclonal antibody|T101|T101 Monoclonal Antibody|T101 monoclonal antibody	An anti-T-cell monoclonal antibody used in Immunotherapy and Radioimmunodetection. (NCI)
C2359	Ricin_Immunoconjugate	Immunotoxin	Ricin Immunoconjugate|Immunoconjugate, Ricin	An immunotoxin; a ricin-containing toxin that can be targeted to specific cells.
C2360	Anabolic_Steroid	Steroid_Compound|Therapeutic_Hormone	Anabolic Steroid|Anabolic-Androgenic Steroids	Synthetic derivatives of the male hormone, androgen, that promote tissue growth by increasing the metabolic processes involved with protein synthesis and are used to promote weight gain in wasting diseases. They are used by bodybuilders and athletes to increase muscle mass, strength, and stamina.(NCI)
C2361	Substituted_Urea	Urea_Nitrogen	Substituted Urea	Class of organic compounds that consist of urea and other compounds including Sulfonyl compounds and have application in pharmaceutical and agricultural preparation. (NCI)
C2362	Podophyllin	Epipodophyllotoxin_Compound	Podophyllin|Mayapple Extract|Podophyllin Derivative|Podophyllin Resin	A resin extracted from the root of the plant Podophyllum sp. Berberidaceae (mandrake), which contains numerous compounds, among which podophyllotoxin is the principal active component.  Podophyllin arrests mitosis in metaphase.  Podophyllotoxin offers advantages over podophyllin in terms of purity, stability and lack of systemic toxicity. (NCI04)
C2363	Aminoglycoside_Antibiotic	Antibiotic|Protein_Synthesis_Inhibitor	Aminoglycoside Antibiotic|Aminoglycoside Agents|Aminoglycoside Drugs|Aminoglycosides|aminoglycoside antibiotics	A broad spectrum antibiotic family derived from Streptomyces containing aminoglycosides that bind to bacterial ribosomes, inhibiting protein synthesis.(NCI)
C2364	Adrenal_Agent	Therapeutic_Steroid_Hormone	Adrenal Agent|Adrenal Drugs	Pharmacological agents which affect the function of the adrenal glands. (NCI)
C2365	Pefloxacin_Penicillin-V	Chemotherapy_Regimen	Pefloxacin/Penicillin V	A drug regimen using Pefloxacin, a fluoroquinolone antibiotic, and Penicillin V, a penicillin antibiotic, that was studied for use as prophylaxis of bacterial infections in Granulocytopenic Cancer.(NCI)
C2366	M-Azidopyrimethamine	Folate_Antagonist	M-Azidopyrimethamine|MZP	An antifolate derived from diaminopyrimidine with cytotoxic properties.  With a mechanism of action similar to that of methotrexate (MTX), m-azidopyrimethamine blocks tetrahydrofolate synthesis, resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. This agent is more lipophilic but less potent than MTX. (NCI04)
C2367	CB10-277	Triazene_Compound	CB10-277|1-p-carboxy-3,3-dimethylphenyltriazine|CB-1O-277	A synthetic derivative of dimethylphenyl-triazene related to dacarbazine, with antineoplastic properties.  Related to the agent dacarbazine, CB10-277 is converted in vivo to a monomethyl triazene form that alkylates DNA, resulting in inhibition of DNA replication and repair; in addition, this agent may act as a purine analogue, resulting in inhibition of DNA synthesis, and may interact with protein sulfhydryl groups. (NCI04)
C2368	Monoclonal_Antibody_14G2A	Monoclonal_Antibody	Monoclonal Antibody 14G2A|14G2A|14G2A, monoclonal antibody|Antibody 14G2A, Monoclonal|MoAb 14G2A|Murine Monoclonal Antibody (14G2A)	A murine monoclonal antibody directed against the ganglioside GD2 with potential antineoplastic activity. Monoclonal antibody 14G2A binds to the ganglioside GD2 and induces antibody-dependent cell mediated cytotoxicity and complement-dependent cytotoxicity against GD2-expressing tumor cells.  GD2 is overexpressed in malignant melanoma, neuroblastoma, osteosarcoma, and small cell carcinoma of the lung. (NCI04)
C2369	Methionyl-Interferon-Consensus	Therapeutic_Interferon_Alfa	Methionyl-Interferon-Consensus|Recombinant methionyl human consensus interferon|interferon consensus, methionyl|methionyl interferon consensus|r-metHuIFN-Con1	An analogue of consensus interferon which contains an additional methionyl amino acid residue.  Consensus interferon (also known as interferon alfacon-1, rCon-IFN, and CIFN) is a genetically engineered synthetic interferon created from the most common amino acid sequences from the naturally occurring alpha interferons.  Alpha interferons bind to specific cell-surface receptors, resulting in the transcription and translation of genes whose protein products have antiviral, antiproliferative, anticancer, and immune-modulating effects. (NCI04)
C2370	Monoclonal_Antibody_3F8	Monoclonal_Antibody	Monoclonal Antibody 3F8|3F8|3F8 Monoclonal Antibody|MoAb 3F8|anti-Ganglioside (GD2) Monoclonal Antibody 3F8|monoclonal antibody 3F8	A murine monoclonal antibody directed against the cell-surface, tumor-associated antigen ganglioside GD2. Vaccination with monoclonal antibody 3F8 may stimulate a host cytotoxic immune response against tumors that express ganglioside GD2. (NCI04)
C2371	Ethylchlorformate	Vaccine_Adjuvant	Ethylchlorformate	A substance used to treat tumor cells for synthesis of a tumor-specific immunotherapeutic agent, ethyl chloroformate polymerized tumor protein, for use in Immunotherapy.(NCI)
C2372	Monoclonal_Antibody_L6	Monoclonal_Antibody	Monoclonal Antibody L6|L6|MOAB L6|MoAb L6	A murine IgG2a monoclonal antibody with potential antineoplastic activity. Monoclonal antibody L6 binds to the L6 antigen, a cell surface glycoprotein overexpressed in many carcinomas, and induces antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity against L6-expressing tumor cells.  This agent may be conjugated with various toxins in order to target their cytotoxic activity to tumor cells expressing the L6 antigen. (NCI04)
C2373	Interleukin-2_Liposome	Therapeutic_Interleukin-2	Interleukin-2 Liposome|Liposome encapsulated interleukin-2	A formulation in which liposomes are loaded with the cytokine interleukin-2 (IL-2). By activating cytotoxic T-lymphocytes, such as lymphokine-activated killer cells, and increasing levels of the cytotoxic cytokines interferon-gamma (IFN-gamma) and transforming growth factor-beta (TGF-beta), IL-2 may exhibit antitumoral activity.  Liposomal formulations of IL-2 may promote entry of the cytokine into target tumor cells and may be used as an immunoadjuvant in cancer vaccine therapy. (NCI04)
C2374	TP40_Immunotoxin	Immunotoxin	TP40 Immunotoxin|TP40|Transforming Growth Factor-Alpha-Pseudomonas Exotoxin-40	Transforming growth factor alpha-Pseudomonas exotoxin-40 (TP40) is a hybrid fusion protein that selectively binds to cancer cells that express the epidermal growth factor receptor. TP40 is then internalized and kills these cells by virtue of its Pseudomonas exotoxin-derived domains.
C2375	Muramyl_Tripeptide_Phosphatidylethanolamine_Liposome	Muramyl_Tripeptide_Phosphatidylethanolamine	Muramyl Tripeptide Phosphatidylethanolamine Liposome|CGP 19835A Lipid|MTP-PE Liposome	A liposome-encapsulated form of the synthetic analogue of muramyl dipeptide (MDP), muramyl tripeptide phosphatidylethanolamine.  Muramyl tripeptide phosphatidylethanolamine activates monocytes and macrophages, resulting in the induction of multiple cytokines (Il-1 alpha and beta, Il-7, IL-8, IL-12, and TNF) and potential tumoricidal activity. (NCI)
C2376	GM2-KLH_Vaccine	Antineoplastic_Vaccine	GM2-KLH Vaccine|GM2-KLH|GM2-KLH Ganglioside|GM2-KLH vaccine|KLH-conjugated GM2 Ganglioside Vaccine	A cancer vaccine consisting of GM2 ganglioside, a melanoma-specific antigen, conjugated with the immunostimulant keyhole limpet hemocyanin. Vaccination with GM2-KLH vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against GM2 ganglioside-expressing melanoma cells, resulting in tumor growth inhibition. (NCI04)
C2377	L-Leucyl-L-Leucine_Methyl_Ester	Immunosuppressant	L-Leucyl-L-Leucine Methyl Ester	A lysosomotropic agent taken up by cells and converted to pro-apoptotic metabolites that are membranolytic for cytotoxic T-cells, Natural Killer (NK) cells, and Lymphokine-activated Killer (LAK) cells.  Studies have treated donor cells ex-vivo with L-Leucyl-L-Leucine Methyl Ester (LLME) to test its ability to prevent Graft Versus Host Disease(GVHD).
C2378	Vinfosiltine	Vinca_Alkaloid_Compound	Vinfosiltine|S12363|Vincaleukoblastine, O4-Deacetyl-3-de(methoxycarbonyl)-3-(((1-(diethoxyphosphinyl)-2-methylpropyl)amin)carbonyl)-,(3(S))-,Sulfate(Salt)	A vinca alkaloid that inhibits mitosis by binding to microtubule protein, tubulin, ultimately inhibiting formation of mitotic spindles.
C2379	Triacetyluridine	Cytoprotective_Agent	Triacetyluridine|PN401|PN401 (triacetyluridine)|RG2133|TAU|triacetyluridine	A substance that is being studied for its ability to protect against the gastrointestinal side effects caused by fluorouracil.  It is a precursor of uridine, which is a component of RNA.
C2380	Anti-B4_Blocked_Ricin_Immunotoxin	Ricin_Immunoconjugate	Anti-B4 Blocked Ricin Immunotoxin|Anti B4-BR|Anti B4bR|Anti-B4 Blocked Ricin|Anti-B4-bR|Monoclonal Antibody Anti-B4 Blocked Ricin	An immunotoxin comprised of an anti-B4 (CD19) murine monoclonal antibody linked to the modified plant-derived toxin blocked ricin. The antibody portion of anti-B4 blocked ricin immunotoxin binds to B lymphocytes that express CD19; the ricin portion cleaves the N-glycosidic bond between the ribose and adenine base at position 4324 in the B lymphocyte 28S ribosomal RNA, resulting in ribosome inactivation, inhibition of protein synthesis, and cell death. (NCI04)
C2381	Etanercept	Immunosuppressant	Etanercept|Enbrel|TNFR:Fc|Tumor Necrosis Factor Receptor IgG Chimera	A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. (NCI04)
C2382	Monoclonal_Antibody_BEC2	Monoclonal_Antibody	Monoclonal Antibody BEC2|BEC2|MoAb BEC2|anti-idiotypic murine monoclonal antibody BEC2|monoclonal antibody BEC2, anti-idiotypic murine	An anti-idiotypic monoclonal antibody that mimics GD3, a tumor antigen for use as an immune stimulant. (NCI)
C2383	DAB389_Epidermal_Growth_Factor	Angiogenesis_Activator_Inhibitor|Fusion_Toxin	DAB389 Epidermal Growth Factor|DAB389 EGF	A recombinant fusion protein composed of the diphtheria toxin with the receptor-binding domain replaced by human epidermal growth factor (EGF).  When administered, EGF binds to the endothelial cell growth factor receptor, EGFR, which is upregulated in many solid tumors.  After binding to the EGF receptor, the agent is internalized by the cell, where the diphtheria toxin moiety exerts its cytotoxic effect, inhibiting protein synthesis through ADP-ribosylation of elongation factor 2. (NCI04)
C2384	Tyrosinase-KLH	Antineoplastic_Vaccine	Tyrosinase-KLH	A vaccine comprised of Tyrosinase, a tumor antigen, conjugated with Keyhole Limpet Hemocyanin (KLH), an immunogenic protein, for use in Immunotherapy. (NCI)
C2385	Theramide	Vaccine_Adjuvant	Theramide	A muramyl dipeptide family member, a potent immunomodulator. It is under development as a vaccine adjuvant. (NCI)
C2386	gp100_Antigen	Tumor_Antigen	gp100 Antigen|glycoprotein 100|gp 100|gp100	A melanoma-associated antigen.  When administered in a vaccine formulation, gp100 antigen may stimulate a cytotoxic T cell HLA-A2.1-restricted immune response against tumors that express this antigen, which may result in a reduction in tumor size. (NCI04)
C2387	Monoclonal_Antibody_LL2	Monoclonal_Antibody_for_Clinical_Diagnosis	Monoclonal Antibody LL2|Anti-CD22 Monoclonal Antibody, LL2|LL2|LL2 monoclonal antibody|MoAb LL2	An anti-CD22 pan-B-cell monoclonal antibody that is used in Immunotherapy. (NCI)
C2388	Liposomal_Cytarabine	Cytosine_Arabinoside	Liposomal Cytarabine|DTC 101|DepoCyt|DepoCyte|DepoFoam|DepoFoam Encapsulated Cytarabine|DepoFoam-encapsulated cytarabine|Encapsulated Cytarabine|Liposomal cytarabine	A liposomal intrathecal formulation of the antimetabolite cytarabine. As an S-phase-specific antimetabolite, cytarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; the incorporation of cytarabine triphosphate into DNA appears to inhibit DNA polymerase and so DNA synthesis, resulting in cell death. (NCI04)
C2389	Daflon_500	Miscellaneous_Adjuvant	Daflon 500	Daflon 500 is a phlebotonic drug and a vascular protecting agent.  It is reported to improve microcirculation in chronic venous insufficiency by improvement of venous tone, inhibition of prostaglandin synthesis, protection against free radicals, activation of the complement system, and increased lymphatic drainage. This results in reduced venous capacitance, distensibility, and emptying time; reduced capillary permeability; and increased capillary resistance. (Angiology 1994 Jun;45(6):419-2)
C2390	Antiseborrheic_Agent	Retired_Concepts	Antiseborrheic Agent	Substances that control the excessive secretion of sebum, the oily secretions from sweat glands.(NCI)
C2391	Radium	Radioactive_Element	Radium	An element with atomic symbol Ra, atomic number of 88, and atomic weight 226.0
C2392	Gold	Element_or_Isotope	Gold	An element with atomic symbol Au, atomic number 79, and atomic weight 197.
C2393	Industrial_Product	Drugs_and_Chemicals_Functional_Classification	Industrial Product	Substances that are either used in or are by-products of the manufacturing process and are often ecological problems or health hazards.(NCI)
C2394	Miscellaneous_Antibiotic	Antibiotic	Miscellaneous Antibiotic	Antibiotic agents with non-specific classifications.(NCI)
C2395	Therapeutic_Hematopoietic_Growth_Factor	Therapeutic_Growth_Factor	Recombinant Hematopoietic Growth Factor	Hematopoietic growth factors promote the development of blood cells.
C2396	I_131_Liothyronine	Radioconjugate	I 131 Liothyronine|Liothyronine I 131	A radioconjugate comprised of liothyronine, a synthetic thyroid hormone T3, labeled with Iodine 131.(NCI)
C2397	PADRE_965_10	Vaccine_Adjuvant	PADRE 965.10|15 Amino Acid Helper Peptide|PADRE 96510	Pan-DR epitope (PADRE) 965.10 is a helper peptide.  PADRE peptides have been shown the capacity to deliver help for antibody responses in vivo. They were also found to be able to provide significant helper T-cell activity in vivo.  Acts as an adjuvant.
C2398	Tretinoin_Liposome	Vitamin_A_Acid	Tretinoin Liposome|AR-623|All-trans-retinoic acid liposomal|Atragen|Liposomal all-trans-retinoic acid|Liposomal tretinoin|Tretinoin Liposomal|TretinoinLF	An intravenous formulation of tretinoin (vitamin A acid or all-trans retinoic acid) encased in liposomes. Tretinoin is a naturally occurring retinoic acid agent that binds to and activates retinoic acid receptors (RAR), effecting changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of carcinogenesis.  This agent also inhibits telomerase, leading to telomere shortening and eventual apoptosis of certain tumor cell types. Liposome encapsulation extends the half-life of intravenously administered tretinoin.
C2399	Bispecific_Antibody_2B1	Bispecific_Antibody	Bispecific Antibody 2B1|2B1|2B1 Antibody, Bispecific|2B1 Bispecific MAb|2B1 Bispecific Murine MAb|MOAB 2B1 Bispecific|MoAb 2B1 Bispecific|bsAb 2B1	A monoclonal antibody with potential antineoplastic activity.  Specific for both the immunoglobulin G (IgG) receptor CD16 and c-erbB-2, bispecific antibody 2B1 may enhance cellular immune responses against c-erbB-2-positive cells, resulting in increased tumor cell lysis. (NCI04)
C2400	GD2-KLH_Vaccine	Antineoplastic_Vaccine	GD2-KLH Vaccine|Ganglioside GD2-KLH|KLH-conjugated GD2 Ganglioside Vaccine	A cancer vaccine consisting of the tumor-associated antigen GD2 ganglioside conjugated with the immunostimulant Keyhole Limpet Hemocyanin (KLH).  Vaccination with GD2-KLH vaccine may induce the production of IgG and IgM antibodies against tumors expressing GD2 ganglioside. (NCI)
C2401	Tyrosinase_Peptide	Tumor_Antigen	Tyrosinase Peptide|Tyrosinase Peptides|tyrosinase peptide	A tumor-specific antigen used in the development of cancer vaccines.
C2402	Octreotide_Pamoate	Octreotide	Octreotide Pamoate|OP LAR|Octreotide Pamoate LAR(SMS 201-995)|Octreotide pamoate|OncoLar|SMS 201-995 pa|SMS 201-995 pa LAR	A synthetic long-acting octapeptide analogue of endogenous somatostatin.  Octreotide pamoate binds to somatostatin receptors expressed by some neuroendocrine and non-neuroendocrine tumor cells, thereby initiating somatostatin receptor-mediated apoptosis. Other possible antineoplastic activities of this agent include suppression of tumor angiogenesis and tumor growth-promoting insulin-like growth factor 1 (IGF-1).  (NCI04)
C2403	Human_Papillomavirus_TA_Vaccine	Antineoplastic_Vaccine	Human Papillomavirus Tumor Antigen Vaccine|Human Papillomavirus TA|Human Papillomavirus TA Vaccine|TA-HPV|TA-Human Papillomavirus vaccine	A recombinant vaccinia virus; encodes HPV types 16 and 18, E6 and E7 proteins; used for immunotherapy of cervical cancer
C2404	Rasburicase	Uricosuric_Agent	Rasburicase|Elitek|NK-631|Rasburicase(SR 29142 Urate Oxidase)|Recombinant Urate Oxidase|SR 29142|SR-29142|Urate Oxidase	A drug that may protect healthy tissue from the toxic effects of anticancer drugs.
C2405	Boronophenylalanine-Fructose_Complex	Radiosensitizing_Agent	Boronophenylalanine-Fructose Complex|p-Boronophenylalanine-Fructose Complex	A boronated phenylalanine complexed with fructose to increase its solubility. When exposed to neutron irradiation, boronophenylalanine absorbs neutrons and self-destructs releasing short-range alpha radiation and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell death. This highly selective, localized radiotargeting of tumor cells, known as boron neutron capture therapy (BNCT), spares adjacent normal tissues.
C2406	gp209-2M_Antigen	Vaccine_Antigen	gp209-2M Antigen|antigen, gp209-2m|gp209-2M	A synthetic peptide (IMDQVPFSV) used to vaccinate patient with metastatic melanoma.  It is a modified gp209 (ITDQVPFSV) peptide, which is part of gp100 antigen.
C2407	MUC-1_Antigen	Tumor_Antigen	MUC-1 Antigen|DF3 Antigen|Episialin|Glycosylated MUC-1|MUC-1|Muc1 Mucin|Mucin Peptide|Mucin Peptide MUC-1|Mucin/Peptide|Polymorphic Epithelial Mucin|mucin/peptide	A protein/sugar compound made by some cancer cells.
C2408	T4N5_Liposomal_Lotion	DNA_Repair_Enzyme_Topical_Agent	T4N5 Liposomal Lotion|Bacteriophage T4 Endonuclease V in Liposomal Lotion|Lotion, T4N5 Liposomal|T4 Endonuclease V Liposomal Lotion|T4N5 liposomal lotion	A topical lotion that contains the enzyme T4-bacteriophage endonuclease V encapsulated within liposomes. With topical liposomal delivery, the DNA repair enzyme T4-bacteriophage endonuclease V is transported into skin cells, where the enzyme enters cell nuclei and binds to and incises pyrimidine dimers, thereby catalyzing the first reaction step of the cellular excision repair pathway for removing DNA replication-inhibiting pyrimidine dimers produced within duplex DNA through exposure to ultraviolet (UV) irradiation. In vitro and in vivo studies indicate that T4N5 liposomes increases repair of DNA damage caused by UV irradiation. (NCI05)
C2409	Monoclonal_Antibody_Me1-14_F_ab_2	Monoclonal_Antibody	Monoclonal Antibody Me1-14 F(ab')2|Me1-14 F(ab')2|Me1-14 F(ab')2 monoclonal antibody|MoAb Me1-14 F(ab')2	The F(ab)2 fragment of Me1-14, a murine IgG2a monoclonal antibody directed against proteoglycan chondroitin sulfate-associated protein expressed by gliomas and melanomas.  By binding to proteoglycan chondroitin sulfate-associated protein, monoclonal antibody Me1-14 F(ab')2 conjugated to a radioisotope may localize gliomas and melanomas when used as a tracer in radioimaging applications; in radioimmunotherapeutic applications, this agent conjugated to a radioisotope may be used to deliver targeted radiotoxicity to these tumors.
C2410	Monoclonal_Antibody_A33	Monoclonal_Antibody	Monoclonal Antibody A33|A33|A33 Monoclonal Antibody|A33 monoclonal antibody|MoAb A33	A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.
C2411	CEP-2563_Dihydrochloride	Tyrosine_Kinase_Inhibitor	CEP-2563 Dihydrochloride|CEP-2563|CEP-2563 dihydrochloride|KT-8391|L-Lysyl-beta-alanine [(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-methoxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-10-yl]methyl Ester Dihydrochloride	A growth factor antagonist that may stop tumor cells from growing.
C2412	Diethylhomospermine	Antidiarrheal_Agent|Polyamine_Inhibitory_Agent	Diethylhomospermine|1,14-bis(ethylamino)-5,10-diazatetradecane|DEHOP|DEHSPM|N(1),N(14)-bis(ethyl)homospermine|N1,N14-diethylhomospermine|N1N14-bis(ethyl)norspermine|N1N14-diethylhomospermine	A polyamine analogue that exhibits antiproliferative activity and acts as an anti-diarrheal agent by delaying intestinal transit and enhancing fluid reabsorption. (NCI)
C2413	Therapeutic_Leukocyte_Interleukin	Therapeutic_Interleukin	Recombinant Leukocyte Interleukin|Buffy Coat Interleukin|Leukocyte Interleukin|Multikine	A naturally derived cytokine product containing tumoricidal/tumoristatic cytokines, chemotactic cytokines and chemokines, and lymphoproliferative and pro-inflammatory cytokines, that exhibits immunomodulatory and immunostimulatory effects. (NCI)
C2414	Carcinoembryonic_Antigen_Peptide_1	Tumor_Specific_Peptide	Carcinoembryonic Antigen Peptide 1|CAP-1|CAP-1 (CEA Peptide 9-mer)|CEA Peptide 1|CEA Peptide 9-mer|Carcinoembryonic Antigen Peptide-1|Carcinoembryonic Peptide-1|carcinoembryonic antigen peptide-1	A nine amino acid peptide fragment of carcinoembryonic antigen (CEA), a protein that is overexpressed in several cancer cell types, including gastrointestinal, breast, and non-small cell lung. Autologous vaccination with activated autologous dendritic cells (DC) or peripheral blood mononuclear cells (PBMC) which have been exposed to CEA peptide 1 in vitro may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing CEA, thereby inhibiting tumor growth. (NCI04)
C2415	Potassium_Oxonate	Miscellaneous_Chemoprotective_Agent	Potassium Oxonate|Oxonate Potassium|Oxonate, potassium|Potassium oxonate	Potassium salt of oxonic acid, an inhibitor of uricase (urate oxidase).
C2416	Chlorodihydroxypyridine	Dihydropyrimidine_Dehydrogenase_Inhibitor	Chlorodihydroxypyridine|5-Chloro-2,4-dihydroxypyridinediol|Gimeracil	An agent that enhances the antitumor activity of fluoropyrimidines by inhibiting the enzyme Dihydropyrimidine Dehydrogenase, causing decreased degradation of the fluoropyrimidines.(NCI)
C2417	Monoclonal_Antibody_MX35_F_ab_2	Monoclonal_Antibody	Monoclonal Antibody MX35 F(ab')2|MX35 F(ab')2|MX35 F(ab')2 monoclonal antibody|MoAb MX35 F(ab')2	The F(ab)2 fragment of monoclonal antibody MX35, an epithelial differentiation antigen, that exhibits reactivity with epithelial ovarian cancers.(NCI)
C2418	Bovine_Cartilage	Nutritional_Supplement	Bovine Cartilage	Cartilage extracted from various parts of a cow and is proposed to stimulate the immune system and inhibit tumor cell growth.  It was used in the 1950s and 60s to enhance wound healing. (NCI)
C2419	HPV-16_E7_12-20_Peptide_Vaccine	Human_Papilloma_Virus_Vaccine	HPV-16 E7(12-20) Peptide Vaccine|HPV-16 E7(12-20) peptide|HPV-16E7(12-20) peptide vaccine|HPV16 E7(12-20) peptide|HPV16 E7(12-20) peptide vaccine|HPV16E7(12-20)	A peptide based vaccine consisting of amino acids 12 through 20 of the E7 gene of the Human Papilloma Virus type 16.  HPV-16 E7 12-20 peptide vaccine may elicit a specific CD8 T-cell response to the E7 oncogene protein, thereby inhibiting the abrogation of p53 and pRb function and thus prevent tumorigenesis. (NCI04)
C2420	E1A_Lipid_Complex	Non-Viral_Vector-Gene_Complex	E1A Lipid Complex|E1A-Lipid Complex|Lipid Complex, E1A	E1A gene combined with lipids that serve as a means to deliver the E1A gene into the cancer cells. The combination of lipids and the E1A gene is called the E1A Lipid Complex.
C2421	Tc_99m_Monoclonal_Antibody_170	Radioimmunoconjugate	Tc 99m Monoclonal Antibody 170|Tc99m MOAB 170|Technetium Tc 99m Monoclonal Antibody 170	A radioimmunoconjugate comprised of monoclonal antibody-170 labelled with technetium 99m. (NCI)
C2422	_5-Fluoropyrimidinone	Pyrimidine_Antagonist	5-Fluoropyrimidinone|5-Fluoro-Pyrimidinone	A fluoronucleoside that inhibits pyrimidine synthesis, interfering with DNA synthesis.
C2423	Recombinant_Adenovirus-p53	Viral_Vector-Gene_Complex	Recombinant Adenovirus-p53|SCH 58500|SCH-58500|SCH58500|rAd/p53	A drug that inhibits the growth of tumor cells that express the mutated p53 gene.
C2424	Monoclonal_Antibody_3H1_Anti-Idiotype_Vaccine	Anti-Idiotype_Vaccine	Monoclonal Antibody 3H1 Anti-Idiotype Vaccine|CEA-Vac|CeaVac|MoAb 3H1 anti-idiotype vaccine	A recombinant monoclonal antibody in which the heavy and light chain variable domains mimic a specific epitope of the tumor-associated protein carcinoembryonic antigen (CEA).  This agent is used as a cancer vaccine against tumors that express CEA. (NCI04)
C2425	DetoxPC	Chemo_Immunostimulant_Adjuvant	DetoxPC|Detox PC|Detox PC (Ribi ImmunoChem)|Detox PC Adjuvant|DetoxPC Adjuvant	A detoxified, nonspecific immunostimulant consisting of a combination of the active monophosphoryl lipid A component of lipopolysaccharide (LPS) isolated from the bacterium Salmonella minnesota combined with a residue of the cell wall of the bacterium Mycobacterium phlei.  Detox-PC differs from Detox adjuvant and Detox-B in that Detox-PC contains egg phosphatidylcholine and alpha-tocopherol. (NCI04)
C2426	Dendritic_Cell-MART-1_Peptide_Vaccine	Dendritic_Cell_Tumor_Peptide_Vaccine	Dendritic Cell-MART-1 Peptide Vaccine|MART-1 peptide-pulsed DC vaccine|MART-1 peptide-pulsed dendritic cell vaccine|Vaccine, dendritic cell-MART-1 peptide|dendritic cell MART-1 peptide vaccine	A cancer vaccine consisting of dendritic cells harvested from a patient with cancer and pulsed or transduced with a peptide fragment of MART-1 (melanoma antigen recognized by T-cells), an antigen expressed by melanoma cells.  When the altered dendritic cells are returned to the patient, they stimulate the host immune system to mount a cytotoxic T-lymphocyte immune response against tumor cells expressing MART-1. (NCI04)
C2427	Dendritic_Cell-G9-209-2M_Peptide_Vaccine	Dendritic_Cell_Tumor_Peptide_Vaccine	Dendritic Cell-G9-209-2M Peptide Vaccine|Dendritic Cell G9-209-2M Peptide Vaccine|G9-209-2M Peptide-Pulsed DC Vaccine|G9-209-2M Peptide-Pulsed Dendritic Cell Vaccine|Vaccine, Dendritic Cell-G9-209-2M Peptide	A vaccine comprised of autologous dendritic cells pulsed with G9-209-2m peptide, a modified epitope of the gp100 melanoma-associated antigen. (NCI)
C2428	PA-1-STK_Ovarian_Carcinoma_Vaccine	Antineoplastic_Vaccine	PA-1-STK Ovarian Carcinoma Vaccine	A vaccine comprised of HSV-tk-gene-modified PA-1-STK cells (tumor cells) that exhibits antitumor activity. (NCI)
C2429	Sargramostim_Plasmid_DNA_Sarcoma_Vaccine	Antineoplastic_Vaccine	Sargramostim Plasmid DNA Sarcoma Vaccine|GM-CSF plasmid DNA sarcoma vaccine	A vaccine comprised of irradiated autologous sarcoma cells transfected with a human sargramostim (Granulocyte Macrophage-Colony-Stimulating Factor) gene. (NCI)
C2430	Sargramostim_Plasmid_DNA_Melanoma_Vaccine	Melanoma_Vaccine	Sargramostim Plasmid DNA Melanoma Vaccine Adjuvant|GM-CSF plasmid DNA melanoma vaccine	A vaccine adjuvant consisting of a plasmid DNA encoding sargramostim (a granulocyte macrophage-colony stimulating factor). Upon administration, expressed sargramostim may stimulate a cytotoxic T cell response enhancing the host immune response to a concomitantly administered melanoma vaccine.
C2431	I_131_Monoclonal_Antibody_3F8	Radioimmunoconjugate	I 131 Monoclonal Antibody 3F8|Iodine I 131 Monoclonal Antibody 3F8|iodine I 131 MOAB 3F8	A radioimmunoconjugate consisting of 3F8, a murine anti-GD2 ganglioside monoclonal antibody labeled with iodine 131 (I-131), with radioimaging and radioimmunotherapeutic properties. Using monoclonal antibody 3F8 as a carrier for I-131 results in the targeted imaging and/or destruction of cells expressing GD2. GD2 is a ganglioside which is overexpressed in malignant melanoma, neuroblastoma, and small cell carcinoma of the lung. (NCI04)
C2432	Autologous_gp96_Heat_Shock_Protein_Peptide_Complex_Vaccine	Melanoma_Vaccine	Autologous gp96 Heat Shock Protein Peptide Complex Vaccine|HSP gp96-Peptide Complex|HSPPC-96|Heat Shock Protein Peptide Complex-96|Heat Shock Protein-Peptide Complex (HSPPC-96)|Oncophage|gp96 HSP-Peptide Complex|gp96 Heat Shock Protein-Peptide Complex	An autologous cancer vaccine derived from tumor-specific gp96 heat shock proteins.  Heat shock proteins chaperone peptides through the endoplasmic reticulum, are key regulators of dendritic cell maturation, migration and antigen processing, and are involved in T-cell activation. (NCI04)
C2433	Vaccinia_Prostate_Specific_Antigen_Vaccine	Vaccinia_Vaccine	Vaccinia Prostate Specific Antigen Vaccine|PROSTVAC|Prostate Specific Antigen Expressing Vaccinia Virus Vaccine|RV-PSA (RECOMB VACCINIA/PSA-CV-1)|Vaccinia PSA Vaccine|Vaccinia-PSA Vaccine|Vaccinia-Prostate-Specific Antigen Vaccine|rV-PSA|rV-PSA (Prostvac)|rV-PSA Vaccine	A vaccine consisting of recombinant vaccinia virus encoding prostate specific antigen (PSA).  Vaccination with vaccinia-PSA stimulates the host immune system to mount a cytotoxic T-cell response against tumor cells expressing PSA. (NCI04)
C2434	Environmental_Tobacco_Smoke	Environmental_Carcinogen|Tobacco_Smoke	Environmental Tobacco Smoke|ETS|Second Hand Smoke|environmental tobacco smoke	Environmental tobacco smoke. Smoke that comes from the burning of a tobacco product and smoke that is exhaled by smokers (second-hand smoke). Inhaling ETS is called involuntary or passive smoking.
C2435	Anti-CD7_Immunotoxin	Immunotoxin	Anti-CD7 Immunotoxin|Anti CD7 immunotoxin|Immunotoxin, anti CD7|immunotoxin, anti-CD7	A toxin linked to an anti-CD7 antibody.
C2436	Monoclonal_Antibody_A1G4_Anti-Idiotype_Vaccine	Anti-Idiotype_Vaccine	Monoclonal Antibody A1G4 Anti-Idiotype Vaccine|A1G4 anti-idiotype monoclonal antibody vaccine	A vaccine comprised of an anti-idiotype rat monoclonal antibody A1G4, that targets ganglioside GD2. (NCI)
C2437	IL-2_Plasmid_DNA-Lipid_Complex	Non-Viral_Vector-Gene_Complex	IL-2 Plasmid DNA/Lipid Complex|IL-2 Plasmid DNA/DMRIE/DOPE lipid complex|Leuvectin|VCL-1102|interleukin-2 DNA/lipid complex|leuvectin|plasmid DNA IL-2 lipid complex	A non-viral vector gene complex comprised of a plasmid DNA encoding human Interleukin-2 (IL-2) complexed in a 5:1 ratio with a cationic lipid, 1,2-dimyristyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide/dioleyl-phosphatidyl-ethanolamine (DMRIE/DOPE), that facilitates the transfection of plasmid DNA, resulting in expression of a biologically active IL-2. (NCI)
C2438	Ras_Peptide_Cancer_Vaccine	Vaccine_Antigen	RAS Peptide Cancer Vaccine	A cancer vaccine containing a RAS oncogene-encoded peptide with potential antineoplastic activity.  RAS peptide cancer vaccine may stimulate a RAS peptide-specific antitumoral T-cell cytotoxic immune response, resulting in an inhibition of tumor cell proliferation and tumor cell death. (NCI04)
C2439	Carcinoembryonic_Antigen_RNA-pulsed_DC_Cancer_Vaccine	Dendritic_Cell_Tumor_Peptide_Vaccine	Carcinoembryonic Antigen RNA-pulsed DC Cancer Vaccine|CEA RNA-pulsed DC cancer vaccine|CEA RNA-pulsed dendritic cell cancer vaccine|carcinoembryonic antigen RNA-pulsed dendritic cell cancer vaccine	A vaccine comprised of autologous dendritic cells pulsed with mRNA-encoded Carcinoembryonic Antigen (CEA) targeting tumor cells expressing CEA. (NCI)
C2440	I_124_Monoclonal_Antibody_A33	Radioimmunoconjugate	I 124 Monoclonal Antibody A33|Iodine I 124 Monoclonal Antibody A33|iodine I 124 MOAB A33	A radioimmunoconjugate comprised of a monoclonal antibody that recognizes A33, a cell surface glycoprotein expressed in human colonic epithelium and colon cancer, labelled with Iodine 124.(NCI)
C2441	Interleukin-4_pe38kdel_Immunotoxin	Immunotoxin	Interleukin-4 pe38kdel Immunotoxin|IL-4 Fusion Toxin|IL-4 PE38KDEL Immunotoxin|Interleukin-4 Fusion Toxin|Interleukin-4 Pseudomonas Exotoxin|NBI-3001|interleukin-4 PE38KDEL cytotoxin|interleukin-4 pe38kdel immunotoxin	A substance that is being studied as an anticancer drug.  It belongs to the family of drugs called recombinant chimeric proteins.  Also called NBI-3001.
C2442	Canarypox-hIL-12_Melanoma_Vaccine	ALVAC_Vaccine	Canarypox-hIL-12 Melanoma Vaccine|ALVAC-hIL-12|ALVAC-hIL-12 melanoma vaccine	A vaccine consisting of a replication-defective recombinant canarypox virus (ALVAC) that encodes the gene for human interleukin-12 (hIL-12).  Produced mainly by B-cells, IL-12 is an endogenous cytokine that activates natural killer (NK) cells, promotes cytotoxic T lymphocyte (CTL) responses, induces the release of interferon-gamma (IFN-gamma), and may exhibit antitumor and anti-angiogenic effects.  Vaccination with canarypox-hIL-12 melanoma vaccine may stimulate the host immune system to mount an immune response against tumor cells, thereby inhibiting tumor growth and/or metastasis. (NCI04)
C2443	Timcodar_Dimesylate	Multidrug_Resistance_Modulator	Timcodar Dimesylate|Timcodar|VX 853|VX-853	A drug being studied to make cancer cells less resistant to the effects of chemotherapy.
C2444	I_131_Monoclonal_Antibody_Anti-B1	Radioimmunoconjugate	I 131 Monoclonal Antibody Anti-B1|131-I-Anti-B1 Antibody|131-I-Anti-B1 Monoclonal Antibody|I131-MOAB-B1|Iodine I 131 MOAB Anti-B1|Iodine I 131 Monoclonal Antibody Anti-B1|Iodine-131 Anti-B1 Antibody|Iodine-131 Anti-CD20 Monoclonal Antibody	A monoclonal antibody directed against a protein (CD20) expressed on the surface of B-lymphocytes and radiolabeled with the radioisotope I 131 with potential antineoplastic activity.  Radioimmunotherapy using radiolabeled antibodies delivers radiation directly to neoplastic cells, decreasing the risk for systemic radiotoxicity. (NCI04)
C2445	Sargramostim_Plasmid_DNA_Pancreatic_Tumor_Cell_Vaccine	Antineoplastic_Vaccine	Sargramostim Plasmid DNA Pancreatic Tumor Cell Vaccine|GM-CSF plasmid DNA pancreatic tumor cell vaccine	A vaccine comprised of irradiated allogenic pancreatic tumor cells transfected with a human sargramostim (Granulocyte Macrophage-Colony-Stimulating Factor) gene. (NCI)
C2446	Monoclonal_Antibody_11D10	Monoclonal_Antibody	Monoclonal Antibody 11D10|11D10|MoAb 11D10	An anti-idiotype monoclonal antibody that mimics an epitope of the human milk fat globule, an antigen expressed by breast cancer cells, used in Vaccine Therapy.(NCI)
C2447	Monoclonal_Antibody_A27_15	Monoclonal_Antibody	Monoclonal Antibody A27.15|A27.15|ANTI-TRANSFERRIN MOAB 27.15|MoAb A27.15	A murine IgG1 monoclonal antibody directed against the human transferrin (Tf) receptor. Monoclonal antibody A27.15 binds to the Tf receptor, blocking the binding of transferrin to the receptor and resulting in decreased tumor cell growth. (NCI04)
C2448	Monoclonal_Antibody_E2_3	Monoclonal_Antibody	Monoclonal Antibody E2.3|Anti-Transferrin MOAB E2.3|E2.3|MoAb E2.3	A murine IgG1 monoclonal antibody directed against the human transferrin (Tf) receptor. Monoclonal antibody E2.3 binds to the Tf receptor, blocking the binding of transferrin to the receptor and resulting in decreased tumor cell growth. (NCI04)
C2449	I_131_Monoclonal_Antibody_G-250	Radioimmunoconjugate	I 131 Monoclonal Antibody G-250|Iodine I 131 Monoclonal Antibody G-250|iodine I 131 MOAB G 250|iodine I 131 MOAB G-250|iodine I 131 MOAB G250|iodine I 131 monoclonal antibody G250	A radioimmunoconjugate comprised of the chimeric monoclonal antibody G-250 that targets G250, a renal-cell carcinoma-associated antigen, labelled with Iodine 131 for use in Radioimmunotherapy. (NCI)
C2450	Sn_117m_Pentetic_Acid	Radioconjugate	Sn 117m Pentetic Acid|Sn-117m DTPA|Tin Sn 117m DTPA|tin Sn 117m DTPA	A radioactive chemical being studied to treat bone pain associated with cancer.
C2451	Adenovirus_p53	Viral_Vector-Gene_Complex	Adenovirus p53|Ad-p53|Adeno-P53|Adeno-p53	A gene therapy agent consisting of non-replicative adenovirus genes and a normal p53 gene, encoding a transcription factor that plays a vital role in preventing cancer onset.  This adenovirus vector is designed to transfer the p53 gene into nuclei of cancer cells in order to re-establish normal control of gene expression that leads to apoptosis of abnormal cells. (NCI)
C2452	Aminocamptothecin_Colloidal_Dispersion	Aminocamptothecin	Aminocamptothecin Colloidal Dispersion|9-aminocamptothecin colloidal dispersion|9AC colloidal dispersion	A colloidal dispersion formulation of 9-Aminocamptothecin, a water-insoluble camptothecin derivative.  Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single-strand DNA breakages.  Because the terminal lactone ring of aminocamptothecin required for the agent's antitumor activity spontaneously opens under physiological conditions to an inactive carboxy form, the drug must be administered over an extended period of time to achieve effective cytotoxicity. (NCI)
C2453	ERB-38_Immunotoxin	Immunotoxin	ERB-38 Immunotoxin|ERB-38|Erb-38|erb-38 immunotoxin	A bivalent fusion protein consisting of disulfide-stabilized Fv fragments of an anti-HER2 (erbB2) monoclonal antibody (e23) and a truncated version of the M(r) 38 fragment of Pseudomonas exotoxin that lacks the toxin's cell binding domain. ERB-38 immunotoxin binds specifically to cells that overexpress HER2, the antigenic target of the monoclonal antibody; the exotoxin portion of the immunotoxin then lyses the cells bound by the antibody portion. (NCI04)
C2454	COL-3	Matrix_Metalloproteinase_Inhibitor	COL-3|4-Dimethlyamino Sancycline|4-Dimethlyaminosancycline|4-dedimethylamino sancycline|6-deoxy, 6-demethyl, 4-de-dimethylamino tetracycline|6-deoxy-6-demethyl-4-dedimethylaminotetracycline|CMT-3|COL 3|COL-3 (Metastat)|Metastat	A chemically-modified tetracycline with potential antineoplastic activity.  COL-3 inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis.  This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis. (NCI04)
C2455	Recombinant_Human_Keratinocyte_Growth_Factor	Radioprotective_Agent|Therapeutic_Fibroblast_Growth_Factor	Recombinant Human Keratinocyte Growth Factor|Growth Factor, Recombinant Human Keratinocyte|Keratinocyte Growth Factor, Recombinant Human|rhKGF|rhu Keratinocyte Growth Factor	A recombinant form of the natural human Keratinocyte Growth Factor that has been shown to simulate proliferation, migration, and differentiation of a variety of epithelial cell types. (NCI)
C2456	Anti-CEA_Antibody	Monoclonal_Antibody	Anti-CEA Antibody|anti-CEA antibody	An antibody against carcinoembryonic antigen (CEA), a protein present on certain types of cancer cells.
C2457	c-FOS_Antisense	Antisense_Agent	c-FOS Antisense|Antisense c-FOS|antisense c-fos	An oligonucleotide targeting the c-fos gene which decreases c-fos target mRNA and protein expression, thereby inducing differentiation and inhibiting cell proliferation. (NCI)
C2458	Autologous_Tumor_Cells	Biological_Agent	Autologous Tumor Cells|autologous tumor cells	Cancer cells from an individual's own tumor.
C2459	Chemoprotective_Agent	Protective_Agent	Chemoprotective Agent|Chemoprotectants|Chemoprotective|Chemoprotective Drugs|chemoprotective	A quality of some drugs used in cancer treatment. Chemoprotective agents protect healthy tissue from the toxic effects of anticancer drugs.
C2460	Arzoxifene_Hydrochloride	Arzoxifene	Arzoxifene Hydrochloride|2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]benzo[b]thiophene-6-ol hydrochloride|Arzoxifene.HCl|Arzoxifenehydrochloride|LY 353381 HCI|LY353381 Hydrochloride|LY353381 hydrochloride|LY353381.HCl|SERM-3|SERM3	A hormone substance used in the treatment of some types of cancer.
C2461	NR-LU-10_Antigen	Tumor_Antigen	Ep-CAM|17-1A|EGP-2|Epithelial Cell Adhesion Molecule|GA733-2|NR-LU-10 Antigen|NR-LU-10 antigen	A protein found on the surface of some cancers.
C2462	Radioactive_Iodine	Radioisotope	Radioactive Iodine|radioactive iodine	(RAY-dee-o-AK-tiv EYE-uh-dine) A radioactive form of iodine, often used for imaging tests or as a treatment for cancer. For imaging tests, the patient takes a small amount of radioactive iodine by mouth, and it collects in the thyroid. A probe is used to scan the thyroid. For treatment, the patient takes a large dose of radioactive iodine, which kills thyroid cells.
C2463	Retroviral_Vector	Cloning_Vector	Retroviral Vector|retroviral vector	RNA from a virus that is used to insert genetic material into cells.
C2464	CD80_Breast_Cancer_Vaccine	Antineoplastic_Vaccine	CD80 Breast Cancer Vaccine	A vaccine comprised of CD80-transfected allogenic breast cancer cells to induce T-cell response.  (NCI)
C2465	MUC-2-KLH_Vaccine	Antineoplastic_Vaccine	MUC-2-KLH Vaccine|MUC-2-KLH|vaccine, MUC-2-KLH	A vaccine comprised of MUC-2 antigen conjugated with Keyhole Limpet Hemocyanin (KLH). (NCI)
C2466	Peptide_946_Melanoma_Vaccine	Melanoma_Vaccine	Peptide 946 Melanoma Vaccine	A vaccine comprised of peptide 946, a gp100 peptide recognized by melanoma-specific cytotoxic T lymphocytes. (NCI)
C2467	Peptide_946-Tetanus_Peptide_Conjugate_Melanoma_Vaccine	Melanoma_Vaccine	Peptide 946-Tetanus Peptide Conjugate Melanoma Vaccine	A vaccine comprised of peptide 946, a gp100 peptide recognized by melanoma-specific cytotoxic T lymphocytes, conjugated with a modified T-helper epitope from tetanus toxoid. (NCI)
C2468	Tetanus_Peptide_Melanoma_Vaccine	Melanoma_Vaccine	Tetanus Peptide Melanoma Vaccine	A vaccine consisting of peptides derived from melanoma-associated antigens and a modified T-cell epitope derived from tetanus toxoid. Vaccination with this agent may stimulate a host cytotoxic and helper T-cell response against tumor cells expressing melanoma-associated antigens, resulting in decreased tumor growth. (NCI04)
C2469	Peptide_946-Tetanus_Peptide_Conjugate_Melanoma_Vaccine-QS21	Melanoma_Vaccine	Peptide 946-Tetanus Peptide Conjugate Melanoma Vaccine/QS21|p946-Tet p/QS21	A vaccine comprised of peptide 946, a gp100 peptide recognized by melanoma-specific cytotoxic T lymphocytes, conjugated with a modified T-helper epitope from tetanus toxoid and emulsified with QS21, a saponin vaccine adjuvant. (NCI)
C2470	Monoclonal_Antibody_3622W94	Monoclonal_Antibody	Monoclonal Antibody 3622W94|3622W94|MoAb 3622W94	A humanized anti-epithelial cell adhesion molecule (17-1A epithelial antigen) monoclonal antibody. (NCI)
C2471	Ad5CMV-p53_Gene	Viral_Vector-Gene_Complex	Ad5CMV-p53 Gene|Ad5CMV p53 Gene|Advexin|INGN-201|RPR/INGN-201|p53 Gene, Ad5CMV	A replication-defective adenoviral-CMV vector that encodes a wild-type p53 gene. Ad5CMV-p53 induces tumor cells that have been transfected with the vector to produce wild-type p53, a tumor suppressor gene that is deleted or mutated in a significant number of cancers. In transfected tumor cells, the wild-type p-53 gene product exerts an antitumor effect by blocking cell cycle progression at the G1/S regulation point, activating DNA repair proteins in the presence of DNA damage, and initiating apoptosis when DNA damage is irreparable.  (NCI04)
C2472	LMB-9_Immunotoxin	Immunotoxin	LMB-9 Immunotoxin|B3 (dsFv)-PE38|Immunotoxin LMB-9|LMB-9|LMB-9 immunotoxin	A recombinant disulfide stabilized anti-Lewis Y IgG immunotoxin containing a 38 KD toxic element derived from the Pseudomonas Aeruginosa exotoxin A and a monoclonal antibody fragment, designed to attack adenocarcinomas expressing Lewis Y. LMB-9 immunotoxin attaches to tumor cells, facilitating he entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. (NCI04)
C2473	Dendritic_Cell_CEA_Peptide_Vaccine	Dendritic_Cell_Tumor_Peptide_Vaccine	Dendritic Cell CEA Peptide Vaccine|CEA peptide-pulsed DC vaccine|CEA peptide-pulsed dendritic cell vaccine|Dendritic Cell-CEA Peptide Vaccine|Dendritic cell-carcinoembryonic antigen peptide vaccine|Vaccine, dendritic cell-CEA peptide|peptide vaccine, dendritic cell-CEA	A cancer vaccine consisting of dendritic cells harvested from a patient with cancer and pulsed or transduced with a peptide fragment of carcinoembryonic antigen (CEA), a tumor-associated antigen expressed by a wide range of cancers.  When the altered dendritic cells are returned to the patient, they may stimulate the host immune system to mount a cytotoxic T-lymphocyte immune response against tumor cells expressing CEA.
C2474	Tn_c_KLH_Conjugate_Vaccine	Antineoplastic_Vaccine	Tn(c)-KLH Conjugate Vaccine|Tn(c)-KLH	A vaccine comprised of a Tn(c) antigen conjugated with Keyhole Limpet Hemocyanin (KLH). (NCI)
C2475	Promegapoietin	Therapeutic_Colony_Stimulating_Factor	Promegapoietin|SC 71858|promegapoietin	A colony-stimulating factor that stimulates the production of blood cells, especially platelets; it is given during chemotherapy to increase blood cell regeneration. Promegapoietin is a cytokine that belongs to the family of drugs called hematopoietic (blood-forming) agents.
C2476	Monoclonal_Antibody_muJ591	Monoclonal_Antibody	Monoclonal Antibody muJ591|MoAb muJ591|muJ591|muJ591 Monoclonal Antibody|muJ591 monoclonal antibody	A monoclonal antibody against the external domain of the Prostate Membrane Specific Antigen.
C2477	I_131_Monoclonal_Antibody_A33	Radioimmunoconjugate	I 131 Monoclonal Antibody A33|Iodine I 131 Monoclonal Antibody A33	A radioimmunoconjugate comprised of a monoclonal antibody that recognizes A33, a cell surface glycoprotein expressed in human colonic epithelium and colon cancer, labelled with Iodine 131. (NCI)
C2478	Dinitrophenyl	Vaccine_Adjuvant	Dinitrophenyl	A hapten used as an adjuvant to modify proteins in vaccine therapy. (NCI)
C2479	Beta_Endorphin	Endorphin	Beta Endorphin|beta-Endorphin|beta-endorphin	A neuropeptide that mediates pain perception.
C2480	Tracer	Reagent	Tracer|Label|Tag|tracer	A substance (such as a radioisotope) used in imaging procedures.
C2481	Cetrorelix	Gonadotropin_Releasing_Hormone_Inhibitor	Cetrorelix|Cetrorelix Acetate|Cetrotide|D-20761|SB-75	A synthetic luteinizing hormone-releasing hormone (LH-RH) antagonist that suppresses LH and sex steroid levels.
C2482	Miscellaneous_Antiviral_Agent	Antiviral_Agent	Miscellaneous Antiviral Agent|Miscellaneous Antivirals	Antiviral agents that have a non-specific classification.(NCI)
C2483	Miscellaneous_Hormone_Agent	Therapeutic_Hormone	Miscellaneous Hormone Agent|Miscellaneous Hormones	Therapeutic hormones that have a non-specific classification.(NCI)
C2484	Methaqualone_Hydrochloride	Methaqualone	Methaqualone Hydrochloride|Melsedin|Mequelon|Metadorm|Methaqualone HCl|Methaqualone hydrochloride|Methased|Optimil|Paxidorm|Revonal|Riporest|Sedaquin|Sleepinal|Somnium|Toquilone|Toraflon	The hydrochloride salt form of Methaqualone.  As a sedative, hypnotic agent, methaqualone was used for insomnia.  Due to its high risk for abuse, methaqualone was taken off the U.S. market in 1983. (NCI)
C2485	ALVAC-hB7_1	ALVAC_Vaccine	ALVAC-hB7.1	A vaccine comprise of a canarypox viral vector that carries the gene for human B7.1 (CD80 antigen) with potential use as an autologous therapeutic cancer vaccine.  Tumor cells harvested from a patient are infected with ALVAC-hB7 1, thereby producing an autologous cell line that exhibits increased expression of HLA class I and class II, CD54 (ICAM), and CD80. Increased expression of these proteins by this autologous cell line may activate an antitumor T-cell response when the modified cells are administered to the patient. (NCI04)
C2486	Interleukin-1_Receptor_Antagonist	Immunosuppressant	Interleukin-1 Receptor Antagonist|IL-1ra|IL1RN	A recombinant form of the naturally occurring Interleukin-1 Receptor Antagonist that blocks the biological activity of Interleukin-1 by binding to the Interleukin-1 receptor.  Clinical Use: Rheumatoid Arthritis.(NCI)
C2487	Polifeprosan_20_with_Carmustine_Implant	Nitrosourea_Compound	Polifeprosan 20 with Carmustine Implant|Carmustine Copolymer|Gliadel Wafer|Gliadel Wafers	A synthetic, biodegradable wafer containing the agent carmustine with antineoplastic activity. Used to deliver drug directly into a brain tumor site and typically implanted post-surgically, the wafer is made of a biodegradable poly-anhydride copolymer and contains the nitrosourea carmustine.  As an antineoplastic nitrosourea, carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.  Carmustine also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect.  Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04)
C2488	I_131_Monoclonal_Antibody_81C6	Radioimmunoconjugate	I 131 Monoclonal Antibody 81C6|Iodine I 131 Monoclonal Antibody 81C6|iodine I 131 MOAB 81C6	A radioimmunoconjugate consisting of 81C6, a murine IgG2 anti-tenascin monoclonal antibody labeled with iodine 131 (I-131), with radioimaging and radioimmunotherapeutic properties. Using monoclonal antibody 81C6 as a carrier for I-131 results in the targeted imaging and/or destruction of cells expressing tenascin. Tenascin is an extracellular matrix protein which is overexpressed in gliomas and other cancers. (NCI04)
C2489	I_123_Monoclonal_Antibody_81C6	Radioimmunoconjugate	I 123 Monoclonal Antibody 81C6|Iodine I 123 Monoclonal Antibody 81C6|iodine I 123 MOAB 81C6	A radioimmunoconjugate comprised of an IgG2 monoclonal antibody reactive with the extracellular matrix protein tenascin, which is overexpressed in gliomas, carcinomas of the breast and prostate, and other neoplasms, labelled with Iodine 123. (NCI)
C2490	At_211_Monoclonal_Antibody_81C6	Radioimmunoconjugate	At 211 Monoclonal Antibody 81C6|Astatine 211 Conjugated 81C6 Anti-Tenascin Monoclonal Antibody|Astatine At 211 MOAB 81C6|Astatine At 211 Monoclonal Antibody 81C6|Astatine-211 Labelled Anti-Tenascin Monoclonal Antibody 81C6	Antitenascin antibody linked to an alpha-emitting radionuclide.  Being used in trial for treatment of glioma.
C2491	Pegylated_Interferon_Alfa	Therapeutic_Interferon_Alfa	Pegylated Interferon Alfa|PEG-IFN-a|PEG-interferon alfa	A covalent conjugate of recombinant interferon alpha and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha protein moiety.  Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. (NCI04)
C2492	Von_Hippel-Lindau_Peptide_Vaccine	Antineoplastic_Vaccine|Vaccine_Antigen	Von Hippel-Lindau Peptide Vaccine|VHL Peptides|VHL peptide vaccine	A cancer vaccine composed of peptides derived from a tumor-associated protein encoded by a mutated Von Hippel-Lindau (VHL) oncogene.  VHL peptide vaccine may stimulate a cytotoxic T cell response against tumor cells expressing the VHL tumor-associated protein. (NCI04)
C2493	Adenovirus_5-CD40-L_Vector	Viral_Vector-Gene_Complex	Adenovirus 5-CD40-L Vector|Ad-CD154|Ad-CD40 Ligand|Ad-CD40L|Adenovirus/CD40-ligand	An adenovirus vector engineered to produce CD40 ligand.  For use as a possible gene therapy agent.  May induce apoptosis through the TNF pathway.
C2494	GPX-100	Anthracycline_Antibiotic	GPX-100|13-deoxydoxorubicin	An analogue of the anthracycline antineoplastic antibiotic doxorubicin.  GPX-100 intercalates DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  GPX-100 was designed to be a non-cardiotoxic anthracycline antibiotic. (NCI04)
C2495	In_111-DOTA-Biotin	Radioconjugate	In 111-DOTA-Biotin	A radioimmunoconjugate comprised of biotin, a vitamin, conjugated to tetra-azacyclododecanetetra-acetic acid (DOTA), a chelating agent, and Indium 111, a radioisotope.  In 111-DOTA-Biotin has been used in 3-step pre-targeting radioimmunotherapy protocols.(NCI)
C2496	Monoclonal_Antibody_Anti-VEGF	Monoclonal_Antibody	Monoclonal Antibody Anti-VEGF|MoAb VEGF	A monoclonal antibody directed against human Vascular Endothelial Growth Factor (VEGF), a protein that stimulates angiogenesis, and prevents VEGF from binding to its receptors, causing inhibition of angiogenesis. (NCI)
C2497	PSA_Prostate_Cancer_Vaccine	Antineoplastic_Vaccine	PSA Prostate Cancer Vaccine|OncoVax-PR	A vaccine that expresses prostate-specific antigen for use in Immunotherapy. (NCI)
C2498	Patent_Blue_V_Dye	Dye	Patent Blue V Dye|dye, patent blue V|dye, patent blue violet|patent blue violet dye	A dye used as an imaging agent to stain lymph vessels. (NCI)
C2499	LMB-1_Immunotoxin	Immunotoxin	LMB-1 Immunotoxin|B3-NLysPE38|Immunotoxin LMB-1|LMB-1|LMB-1 immunotoxin	A chimeric protein consisting of the Fv portion of a monoclonal antibody attached to a fragment of Pseudomonas exotoxin A without its cell-binding region.  LMB-1 immunotoxin targets B3, a Lewis Y-related carbohydrate epitope found on some solid tumors.  The antibody attaches to the tumor cell and the exotoxin stops protein synthesis by inactivating elongation factor 2. (NCI04)
C2500	Antineoplaston_Agent	Differentiation_Inducer	Antineoplaston Agent|Antineoplaston|Antineoplastons|antineoplastons	A class of peptides, amino acid derivatives, and/or organic acids extracted from blood serum, urine, or synthesized chemically.  Antineoplastons inhibit the methylation of nucleic acids and the incorporation of L-glutamine into tumor-cell proteins.  These agents also intercalate into DNA, leading to cell cycle arrest in the G1 phase and inhibition of mitosis and terminal cell differentiation.  In addition, antineoplastons may inhibit RAS oncogene expression and activate the tumor suppressor gene p53, resulting in cell differentiation and apoptosis. (NCI04)
C2501	STn-KLH_plus_Detox_Vaccine	Antineoplastic_Vaccine	STn-KLH plus Detox Vaccine|Sialy-Tn-KLH with Detox B|Theratope|Theratope siayl-Tn-KLH vaccine	A vaccine comprised of a synthetic Sialyl-Tn antigen linked to the protein carrier, keyhole limpet hemocyanin (KLH), administered with immunostimulant, Detox.  Vaccination with STn-KLH plus Detox elicits an IgG-based anti-STn antibody response and ultimately a cytotoxic T-cell response against STn-expressing cancer cells. (NCI)
C2502	Cisplatin_Liposomal	Cisplatin	Cisplatin Liposomal|Cisplatin, Liposomal|Liposomal Cisplatin|SPI-077|SPI-77|STEALTH Cisplatin|STEALTH Liposomal Cisplatin|STEALTH Liposomal Encapsulated Cisplatin|STEALTH Liposome Cisplatin	A synthetic formulation in which the antineoplastic agent cisplatin is encapsulated in lipids.  Cisplatin liposomal consists of small aggregates of cisplatin covered by a single lipid bilayer. Encasement in liposomes improves cisplatin's tumor bioavailability and toxicity profile. Liposomal encapsulation does not affect the pharmacological properties of cisplatin directly.  Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. (NCI04)
C2503	Combretastatin_A4_Phosphate	Tubulin_Binding_Agent	Combretastatin A4 Phosphate|CA4P|CA4PD|COMBRETASTATIN|Combretastatin|Combretastatin A4 Disodium Phosphate|Combretastatin A4 Prodrug|Combretastatin, (+-)|combretastatin A4 phosphate	A water-soluble prodrug derived from the African bush willow (Combretum caffrum) with tumor vascular-targeting activity. In vivo, combretastatin A4 phosphate is dephosphorylated to its active metabolite, combretastatin A4, which binds to tubulin and inhibits microtubule depolymerization, resulting in morphological changes in proliferating endothelial cells.  As a result, the permeability of tumor vasculature is increased, leading to reduced tumor blood flow and ischemic necrosis of tumor tissue.  In vitro, combretastatin A4 phosphate has been shown to be directly cytotoxic to proliferating endothelial cells and tumor cells. (NCI04)
C2504	Dimethylxanthenone_Acetic_Acid	Bioflavonoid|Endothelial_Cell_Inhibitor|Immunostimulant	Dimethylxanthenone Acetic Acid|5,6-Dimethylxanthenone-4-Acetic Acid|5,6-MexXAA|DMXAA|Dimethyloxoxanthene Acetic Acid|dimethylxanthenone acetic acid	A fused tricyclic analogue of flavone acetic acid with potential antineoplastic activity.  Dimethylxanthenone acetic acid induces the cytokines tumor necrosis alpha (TNF-alpha), serotonin and nitric oxide, resulting in hemorrhagic necrosis and a decrease in angiogenesis.  This agent also stimulates the anti-tumor activity of tumor-associated macrophages. (NCI04)
C2505	Monoclonal_Antibody_HeFi-1	Monoclonal_Antibody	Monoclonal Antibody HeFi-1|HeFi-1|MOAB HEFI-1|MoAb HeFi-1	A murine monoclonal antibody with potential antineoplastic activity. Monoclonal antibody HeFi-1 binds to CD30, a cell surface antigen found on mitogen-activated B-cells and T-cells, and Reed-Sternberg cells.  Monoclonal antibody HeFi-1 has been shown to arrest tumor growth and prevent metastasis in animal models. (NCI04)
C2506	In_111_Folic_Acid	Radioconjugate	In 111 Folic Acid|Indium In 111 Folic Acid	A radioimmunoconjugate comprised of folic acid labeled with Indium 111 for use in Radioimmunotherapy targeting tumor-associated folate receptors.(NCI)
C2507	Ro_31-7453	Tubulin_Binding_Agent	Ro 31-7453	An anticancer drug that may prevent cancer cells from dividing.
C2508	Dextromethorphan_Acetic_Acid	Miscellaneous_Angiogenesis_Inhibitor	Dextromethorphan Acetic Acid|dextromethorphan acetic acid	An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors.
C2509	Hu14_18-Interleukin-2_Fusion_Protein	Immunoconjugate	Hu14.18-Interleukin-2 Fusion Protein|EMD 273063|Hu 14.18/IL - 2 Fusion Protein|Hu14.18-IL2|hu14.18-interleukin-2 fusion protein	A recombinant protein consisting of the hu14.18 monoclonal antibody fused to the cytokine interleukin-2 (IL-2).  The monoclonal antibody portion of the fusion binds to tumor cells expressing the GD2 antigen (melanoma, neuroblastoma and certain other tumors), thereby delivering IL-2, which activates a cellular immune response directed against GD2-expressing tumor cells. (NCI04)
C2510	Recombinant_Vaccinia_DF3_MUC1_Vaccine	Vaccinia_Vaccine	Recombinant Vaccinia DF3-MUC1 Vaccine|rV-DF3/MUC1	A vaccine comprised of a recombinant vaccinia virus that expresses DF3/MUC1, a cell surface mucin glycoprotein expressed by most glandular and ductal epithelial cells. (NCI)
C2511	IDEC-In2B8	Retired_Concepts	IDEC-In2B8|IDEC In2B8
C2512	AFP_Gene_Hepatocellular_Carcinoma_Vaccine	Antineoplastic_Vaccine	AFP Gene Hepatocellular Carcinoma Vaccine|vaccine, AFP gene hepatocellular carcinoma	A cancer vaccine composed of naked plasmid DNA of the gene for the tumor-associated antigen alpha-fetoprotein (AFP), a macromolecule that acts as a specific immunologic target for hepatocellular carcinoma. This agent exerts an antitumor effect by inducing cytotoxic T-lymphocytes to attack AFP-expressing tumor cells. (NCI04)
C2513	LMB-2_Immunotoxin	Immunotoxin	LMB-2 Immunotoxin|Anti-Tac(Fv)-PE38|Humanized AntiTac Toxin|Immunotoxin LMB-2|LMB-2|LMB-2 (Anti-TAC(FV)-PE-38)|LMB-2 immunotoxin	A fusion protein consisting of the Fv portion of a monoclonal antibody attached to a 38-kDa fragment of the Pseudomonas exotoxin A (with amino acids 365-380 deleted).  LMB-2 immunotoxin targets the interleukin 2 receptor (also known as IL-2R or CD25) which is expressed on activated normal T and B cells and macrophages and on the cells of various hematologic malignancies.  The antibody attaches to the IL-2R on the cell membrane, facilitating the entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. (NCI04)
C2514	Monoclonal_Antibody_F19	Monoclonal_Antibody	Monoclonal Antibody F19|Anti-F19 Monoclonal Antibody|Anti-FAP (Fibroblast Activation Protein), F19 Epitope, Monoclonal Antibody|F19|F19 monoclonal antibody|MoAb F19	A murine monoclonal antibody directed against fibroblast activation protein, a tumor stroma antigen, with potential antitumor stroma activity. (NCI)
C2515	I_131_Monoclonal_Antibody_F19	Radioimmunoconjugate	I 131 Monoclonal Antibody F19|131I-mAbF19|Iodine I 131 Monoclonal Antibody F19	A radioimmunoconjugate comprised of a monoclonal antibody directed against fibroblast activation protein, a tumor stroma antigen, labelled with Iodine 131. (NCI)
C2516	Geldanamycin_Analogue	Ansamycin_Antineoplastic_Antibiotic|Differentiation_Inducer	Geldanamycin Analogue|geldanamycin analogue	A class of agents containing analogues of the benzoquinone antineoplastic antibiotic geldanamycin.  A geldanamycin analogue binds to HSP90, a chaperone protein that aids in the assembly, maturation, and folding of proteins.  Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.
C2517	Melanoma_Vaccine	Antineoplastic_Vaccine	Melanoma Vaccine|melanoma vaccine	A cancer vaccine prepared from human melanoma cancer cells. It can be used alone or with other therapy in treating melanoma.
C2518	GI14721	Camptothecin_Analogue	GI14721	An antitumor drug that belongs to the family of drugs called topoisomerase inhibitors. It is a camptothecin analogue.
C2519	Barium_Solution	Contrast_Agent	Barium Solution|barium solution	A liquid containing barium sulfate that is used in x-rays to highlight parts of the digestive system.
C2520	KSA-KLH_Conjugate_Vaccine	Antineoplastic_Vaccine	KSA-KLH Conjugate Vaccine|KSA-KLH	A vaccine comprised of the human pancarcinoma antigen (KSA) conjugated with Keyhole Limpet Hemocyanin (KLH). (NCI)
C2521	Fowlpox_Virus_Vaccine	HIV_Vaccine|Recombinant_Viral_Vaccine	Fowlpox Virus Vaccine|Fowlpox Vaccine	A recombinant virus-based vaccine that contains various peptide antigens.  Fowlpox virus is an attractive vector because its genome is easy to manipulate and it does not multiply in human tissues.  Strong CD8 T cell responses may be induced after prolonged immunization and have been associated with tumor regression.
C2522	DTGM_Fusion_Protein	Immunotoxin	DTGM Fusion Protein|DT-GM-CSF|DTGM|DTGM fusion protein|Diptheria Toxin-Human Granulocyte-Macrophage Colony-Stimulating Factor Fusion Protein|GM-CSF-Diptheria Toxin Fusion Protein	An anticancer drug formed by the combination of diphtheria toxin and a colony-stimulating factor (GM-CSF). The colony-stimulating factor is attracted to cancer cells, and the diphtheria toxin kills the cells.
C2523	Monoclonal_Antibody_CD19	Monoclonal_Antibody	Monoclonal Antibody CD19|CD19, monoclonal antibody|MoAb CD19	A monoclonal antibody directed against the CD19 antigen, expressed on human B lymphocytes. (NCI)
C2524	Monoclonal_Antibody_CD20	Monoclonal_Antibody	Monoclonal Antibody CD20|MoAb CD20|monoclonal antibody, CD20	A monoclonal antibody directed against the CD20 antigen, expressed on the cell surface of B-cell lymphomas. (NCI)
C2525	GVAX_Prostate_Cancer_Vaccine	GVAX_Cancer_Vaccine	GVAX Prostate Cancer Vaccine|Allogeneic Prostate Cancer Vaccine, GM- CSF Gene Transduced|Allogenic Prostate GVAX|GM-CSF Gene Transduced Allogeneic Prostate Cancer Vaccine|GM-CSF prostate cancer vaccine|GVAX Allogeneic Prostate Cancer Vaccine|GVAX Allogenic Prostate Cancer Vaccine|GVAX Prostate|Prostate Cancer Vaccine, GVAX|Prostrate Cancer Vaccine, GM-CSF Gene Transduced	An allogenic vaccine comprised of irradiated, genetically modified prostate cancer cells transfected with a human Granulocyte Macrophage-Colony-Stimulating Factor gene. (NCI)
C2526	Anhydrovinblastine	Vinca_Alkaloid_Compound	Anhydrovinblastine|anhydrovinblastine	An anticancer drug that belongs to the family of drugs called mitotic inhibitors.
C2527	I_131_Monoclonal_Antibody_BC8	Radioimmunoconjugate	I 131 Monoclonal Antibody BC8|I 131 MOAB BC8|Iodine I 131 Monoclonal Antibody BC8|MOAB BC8, iodine I 131|iodine I 131 MOAB BC8|monoclonal antibody BC8, iodine I 131	A radioimmunoconjugate consisting of BC8, a murine IgG1 anti-CD45 monoclonal antibody labeled with iodine 131 (I-131), with radioimmunotherapeutic properties. Using monoclonal antibody BC8 as a carrier for I-131 results in the targeted destruction of cells expressing CD45. CD45 is tyrosine phosphatase expressed on virtually all leukocytes, including myeloid and lymphoid precursors in bone marrow and mature lymphocytes in lymph nodes; it is also expressed on most myeloid and lymphoid leukemic cells, but not on mature erythrocytes or platelets. (NCI04)
C2528	Thompson-Friedenreich_Antigen	Tumor_Antigen	Thompson-Friedenreich Antigen|Antigen, Thompson-Friedenreich|TF(c)	The Thomsen-Friedenreich antigen (TF, chemically: Beta-galactosyl(1-3)-N-acetylgalactosamine) is a cancer-associated blood group-related disaccharide expressed (often coexpressed with MUC1 peptide core) in various epithelial and nonepithelial malignant tumors. It is being tested as a prognostic marker and a potential target in the treatment of patients with colorectal carcinoma. The prognostic relevance of TF expression may - at least in part - be explained by the finding of this glycotope's role as an adhesion molecule in the development of liver metastasis. Data has been accumulated suggesting that TF can be bound by the asialoglycoprotein receptor of hepatocytes or by related endogenous lectin on Kupffer cells.
C2529	TF_c_KLH_Conjugate_Vaccine	Antineoplastic_Vaccine	TF(c)-KLH Conjugate Vaccine|TF (c)-KLH conjugate vaccine|TF(c)-KLH|vaccine, TF (c)-KLH conjugate|vaccine, TF(c)-KLH conjugate	A vaccine comprised of the Thompson-Friedenreich [TF(c)] antigen, a cell surface antigen, conjugated with Keyhole Limpet Hemocyanin (KLH). (NCI)
C2530	MG_98	DNA_Methyltransferase_Inhibitor|Mixed-Backbone_Oligonucleotide	MG 98|MG-98|MG-98 oligonucleotide|MG98	A mixed-backbone oligonucleotide that binds to the 3 untranslated region of DNA methyltransferase mRNA.  Due to binding, MG-98 inhibits DNA methyltransferase, resulting in prevention or reversal of abnormal methylation of tumor suppressor genes and ultimately in tumor growth inhibition or tumor regression.
C2531	Vaccinia-Tyrosinase_Vaccine	Vaccinia_Vaccine	Vaccinia-Tyrosinase Vaccine|VACTYROS|rV-TYR Vaccine	A vaccine consisting of recombinant vaccinia virus encoding the melanoma-associated antigen tyrosinase.  Vaccination with vaccinia-tyrosinase stimulates the host immune system to mount a cytotoxic T-cell response against tumor cells expressing tyrosinase. (NCI04)
C2532	Y_90_Monoclonal_Antibody_m170	Radioimmunoconjugate	Y 90 Monoclonal Antibody m170|MOAB m170, yttrium Y 90|Y 90 MoAb m170|Yttrium Y 90 Monoclonal Antibody m170|monoclonal antibody m170, yttrium Y 90|yttrium Y 90 MOAB m170	A radioimmunoconjugate comprised of a MUC1 monoclonal antibody (m170) labeled with Yttrium 90. (NCI)
C2533	In_111_Monoclonal_Antibody_M170	Radioimmunoconjugate	In 111 Monoclonal Antibody M170|In 111 MOAB m170|Indium In 111 MoAb M170|Indium In 111 Monoclonal Antibody m170|MOAB M170, indium In 111|monoclonal antibody M170, indium In 111	A radioimmunoconjugate comprised of a MUC1 monoclonal antibody (m170) labelled with Indium 111. (NCI)
C2534	Autologous_Expanded_Mesenchymal_Stem_Cells	Biological_Agent	Autologous Expanded Mesenchymal Stem Cells|OTI-010|Stromagen	A drug that is derived from a patient's stem cells (specialized cells in the bone marrow that form new blood cells) and may be given back to the patient to help restore bone marrow that has been damaged by high-dose chemotherapy.
C2535	Serum_Hyaluronic_Acid	Hyaluronic_Acid	Serum Hyaluronic Acid	Hyaluronic acid is a glycoprotein usually found in synovial fluid.  Elevated serum levels are associated with liver disease.
C2536	Canarypox_Antigen	Antigen	Canarypox Antigen|Canarypox Antigens	A genetically engineered live canarypox vector for anti-cancer vaccines. It retains the pancytotropism of most poxviruses, but is unable to productively replicate in nonavian species, thus eliminating the safety concerns that exist for other vectors. Canarypox viral vector induces the infected cells to temporally display tumor-associated antigens linked to a specific cancer, with following activation and expansion of antigen-specific CTL populations and strong T-cell immune response.
C2537	HER-2_neu_Peptide_Vaccine	Antineoplastic_Vaccine	HER-2/neu Peptide Vaccine|HER-2-Neu Peptide Vaccine|HER-2/neu Helper-Peptide Vaccine	A cancer vaccine comprised of peptides derived from the extracellular domain of the tumor-associated antigen Her-2/neu with potential antineoplastic activity. HER-2/neu peptide vaccine may induce antibodies with anti-tumor activity and may also elicit a specific CD8 T-cell response against specific tumor cell types. (NCI04)
C2538	_2IT-BAD_Monoclonal_Antibody_170	Monoclonal_Antibody_170	2IT-BAD Monoclonal Antibody 170|2IT-BAD monoclonal antibody 170	A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.
C2539	BIBX_1382	Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor	BIBX 1382|BIBX1382	A drug that may inhibit tumor cells from multiplying. It is being studied for its ability to treat cancer.
C2540	Mutant_p53_Peptide_Pulsed_Dendritic_Cell_Vaccine	Dendritic_Cell_Tumor_Peptide_Vaccine	Mutant p53 Peptide Pulsed Dendritic Cell Vaccine|dendritic cell vaccine, mutant p53 peptide pulsed|mutant p53 peptide pulsed DC vaccine	A cancer vaccine consisting of autologous dendritic cells which have been pulsed with a mutant p53 peptide. Vaccination with mutant p53 peptide pulsed dendritic cells may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing mutant p53, resulting in tumor cell lysis. Many tumor cells overexpress mutant p53 proteins, resulting in the loss of apoptosis regulation and abnormal cell proliferation. (NCI04)
C2541	Y_90_Monoclonal_Antibody_HMFG1	Radioimmunoconjugate	Y 90 Monoclonal Antibody HMFG1|MOAB HMFG1, yttrium Y 90|Y 90 MoAb HMFG1|Yttrium Y 90 Monoclonal Antibody HMFG1|monoclonal antibody HMFG1, yttrium Y 90|yttrium Y 90 MOAB HMFG1	A radioimmunoconjugate comprised of a monoclonal antibody directed against the Polymorphic Epithelial Mucin (PEM), overexpressed in epithelial tumor cells, labelled with Yttrium 90. (NCI)
C2542	Vaccine-Sensitized_Draining_Lymph_Node_Cells	Miscellaneous_Biologic_Response_Modifier	Vaccine-Sensitized Draining Lymph Node Cells	Cells isolated from lymph nodes from patients, and activated in vitro to generate tumor-specific effector T cells.  Lymph nodes in the lymphatics draining tumors often contain T cells that are immunologically sensitized but functionally deficient. Vaccine-sensitized draining lymph node cells are prepared by isolating these lymphocytes in vitro and stimulating them with cytokines to differentiate into mature effector cells.  Vaccine-draining lymph node cells may also be produced by pharmacological activation of lymph node-derived lymphocytes with drugs such as ionomycin or with bacterial toxin; these activated lymphocytes may be expanded in culture with cytokines such as interleukin-2 prior to infusion into the patient. (NCI04)
C2543	Tositumomab	Monoclonal_Antibody	Tositumomab|Anti-CD20 Antibody|MoAb Anti-B1|Monoclonal Antibody Anti-B1|anti-B1	A murine IgG2 monoclonal antibody directed against the CD20 antigen, found on the surface of B-cells.  Tositumomab binds to the CD20 surface membrane antigen, resulting in apoptosis, and may stimulate antitumoral cell-mediated and/or antibody-dependent cytotoxicity. (NCI04)
C2544	B43-Genistein_Immunoconjugate	Immunoconjugate	B43-Genistein Immunoconjugate	An immunoconjugate comprised of an anti-CD19 monoclonal antibody conjugated with Genistein selectively targeting B-lineage progenitor cells and inhibiting protein tyrosine kinase, causing apoptosis. (NCI)
C2545	Adenovirus_RSV-TK	Viral_Vector-Gene_Complex	Adenovirus RSV-TK	A gene viral vector complex comprised of a replication-defective adenovirus and a herpes simplex virus thymidine kinase gene that activates ganciclovir, causing inhibition of DNA synthesis and apoptosis. (NCI)
C2546	OVA_BiP_Peptide	Vaccine_Antigen	OVA BiP Peptide|OVA-BiP	A hybrid peptide of 19 amino acids derived from ovalbumin and BiP, an endoplasmic reticulum chaperone and a member of the Heat Shock 70 Protein Family, used to potentiate antigen presentation and consequently prime cytotoxic T lymphocyte responses. (NCI)
C2547	Monoclonal_Antibody_Hu3S193	Monoclonal_Antibody	Monoclonal Antibody Hu3S193|Hu3S193|MoAb Hu3S193	A humanized monoclonal antibody directed against the Lewis Y antigen, a tumor-associated epithelial antigen, with potential antineoplastic activity. Following binding, monoclonal antibody Hu3S193 triggers an antibody-dependent cell-mediated cytotoxicity in cells expressing Lewis Y antigen. (NCI05)
C2548	Prostatic_Acid_Phosphatase-Sargramostim_Fusion_Protein	Immunoconjugate	Prostatic Acid Phosphatase-Sargramostim Fusion Protein|PA2024	A genetically-engineered protein formed by the fusion of prostatic acid phosphatase (PAP) and sargramostim (GM-CSF). Vaccination with antigen-presenting cells (APC) loaded with prostatic acid phosphatase-sargramostim fusion protein may elicit a cytotoxic T-cell response against tumor cells that express PAP. (NCI05)
C2549	Interleukin-2_Gene	Transduction_Gene	Interleukin-2 Gene|IL-2 Gene	The DNA sequence that encodes the protein cytokine interleukin-2 (IL-2). When introduced as the complementary DNA (cDNA) form into tumor cells by, for example, a genetically engineered adenovirus vector, the transfected IL-2 cDNA expresses IL-2 which may activate antitumoral natural killer cells and elicit an antitumoral cytotoxic T-cell response, resulting in an inhibition of tumor progression. (NCI04)
C2550	Palladium_103	Radioisotope	Palladium 103|Pd 103|radioactive palladium	A radioactive form of palladium (a metallic element that resembles platinum). When used to treat prostate cancer, radioactive seeds (small pellets that contain radioactive palladium) are placed in the prostate. Cancer cells are killed by the energy given off as the radioactive material decays (breaks down).
C2551	CP-609_754	Farnesyl_Transferase_Inhibitor	CP-609,754	A quinolinone derivative that inhibits farnesyl protein transferase, an enzyme that mediates the farnesylation of RAS, causing possible inhibition of the RAS pathway.  (NCI)
C2552	In_111_Monoclonal_Antibody_Hu3S193	Radioimmunoconjugate	In 111 Monoclonal Antibody Hu3S193|In 111 MoAB Hu3S193|Indium In 111 Monoclonal Antibody Hu3S193	A radioimmunoconjugate comprised of humanized anti-Lewis Y antigen labelled with Indium 111.(NCI)
C2553	pM-81_Monoclonal_Antibody	Monoclonal_Antibody	pM-81 Monoclonal Antibody|pM-81 monoclonal antibody	A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.
C2554	Vaccine_Adjuvant	Immunoadjuvant	Vaccine Adjuvant|vaccine adjuvant	A substance added to a vaccine to improve the immune response so that less vaccine is needed.
C2555	PROST_30_Monoclonal_Antibody	Monoclonal_Antibody	PROST 30 Monoclonal Antibody|PROST 30 monoclonal antibody	A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.
C2556	VNP20009	Non-Viral_Vector	VNP20009|Auxotrophic Lipid A S. Typhimurium mutant|Live, Attenuated Salmonella Typhimurium|VNP 20009	A genetically modified Salmonella bacterium that is injected into the tumor.  It is being studied for its ability to shrink solid tumors.
C2557	Tc_99m_Human_Serum_Albumin_Colloid	Radioconjugate	Tc 99m Human Serum Albumin Colloid|Technetium Tc 99m Human Serum Albumin Colloid	A radioimmunoconjugate comprised of a colloid formulation of human serum albumin labelled with Technetium 99m for diagnostic purposes. (NCI)
C2558	Glufanide_Disodium	Angiogenesis_Activator_Inhibitor	Glufanide Disodium|IM 862|IM-862|IM862	A synthesized version of a naturally occurring dipeptide consisting of L-glutamic acid and L-tryptophan.  IM-862 inhibits vascular endothelial growth factor (VEGF), thereby inhibiting angiogenesis, and increases the production of IL-12, thereby stimulating the immune system. (NCI04)
C2559	Therapeutic_Macrophage_Inflammatory_Protein-2_Alpha	Therapeutic_Alpha_Chemokine	Recombinant Macrophage Inflammatory Protein-2 Alpha|CXCL2|MIP2A Protein	A therapeutic analogue of the endogenous CXC cytokine macrophage inflammatory protein-2 alpha. Macrophage inflammatory protein-2 alpha attracts and activates neutrophils and may play a role in cell proliferation.  In experimental models of acute hepatic injury, macrophage inflammatory protein-2 alpha has been shown to promote liver regeneration by stimulating the proliferation of hepatocytes. (NCI04)
C2560	Therapeutic_Macrophage_Inflammatory_Protein-2_Beta	Therapeutic_Alpha_Chemokine	Recombinant Macrophage Inflammatory Protein-2 Beta|CXCL3|GRO-gamma|GRO3 Protein|MGSA-gamma|MIP2-Beta Protein|Melanoma Growth Stimulatory Activity Gamma	A formulated therapeutic analog of the endogenous pro-inflammatory alpha (CXC) chemokine macrophage inflammatory protein-2 beta that stimulates neutrophil chemotaxis and induces neutrophil degranulation. (NCI04)
C2561	T-Cell_Receptor-Rearrangement_Excision_DNA_Circles	Deoxyribonucleic_Acid	T-Cell Receptor-Rearrangement Excision DNA Circles|TREC	A low level of T-cell receptor-rearrangement excision DNA circles (TREC) in the peripheral blood T cells of HIV-infected patients is an independent predictor of disease progression
C2562	Food_Oil	Dietary_Lipid	Food Oil	Oils obtained from food sources.(NCI)
C2563	Omega-6_Fatty_Acid	Fatty_Acid	Omega-6 Fatty Acid|Omega-6 PUFAs	Essential fatty acids obtained from food sources that are necessary for normal biological functions, as well as growth and development.(NCI)
C2564	Allopurinol_Sodium	Allopurinol	Allopurinol Sodium|4-Hydroxy-1-phenyl-1-pentanone|Adenock|Allo-Puren|Allozym|Allural|Aloprim|Aloral|Alositol|Anoprolin|Anzief|Apulonga|Apurin|Apurol|BW 56158|BW-56158|Bleminol|Bloxanth|Caplenal|Cellidrin|Cosuric|Dabroson|Embarin|Epidropal|Foligan|Geapur|Gichtex|HPP|Hamarin|Hexanurat|Ketanrift|Ketobun-A|Ledopur|Lopurin|Lysuron|Miniplanor|Monarch|Nektrohan|Remid|Riball|Sodium allopurinol|Suspendol|Takanarumin|Urbol|Uricemil|Uripurinol|Urosin|Urtias|Xanturat|Zyloprim|Zyloric	The sodium form of allopurinol, which is a structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. (NCI04)
C2565	Thyroid_Extract	Thyroid_Agent	Thyroid Extract|Armour Thyroid	A desiccated form of natural thyroid from animal tissue comprised mostly of triiodothyronine (T3) and thyroxine (T4).  Clinical Use: Hypothyroidism and Wilsons Syndrome.(NCI)
C2566	Detox-B_Adjuvant	Chemo_Immunostimulant_Adjuvant	Detox-B Adjuvant|Detox-B SE Adjuvant|Detox-B Stable Emulsion|Enhanzyn	A cancer vaccine adjuvant that consists of an oil droplet emulsion of monophosphoryl lipid A and mycobacterial cell wall skeleton.  Detox-B adjuvant is a non-specific immunostimulant that may enhance the host immune response to certain cancer vaccines.  Detox-B differs from Detox adjuvant in that Detox-B contains lecithin. (NCI04)
C2567	Monoclonal_Antibody_CC49	Monoclonal_Antibody_for_Clinical_Diagnosis	Monoclonal Antibody CC49|Antibody CC49, Monoclonal|CC-49 Monoclonal Antibody|CC-49 monoclonal antibody|CC49|MAb CC49|MOAB CC-49/TAG72 (Centocor)|MOAB CC-49/TAG72 (DW)|MoAb CC49|Monoclonal Antibody CC-49	A second-generation murine monoclonal antibody based on the antibody B72.3 that is directed against tumor-associated glycoprotein 72 (TAG72).  TAG72 is expressed by gastric, breast, pancreatic, colorectal, and ovarian carcinoma cells. (NCI04)
C2568	Hydrocortisone_Placebo	Therapeutic_Hydrocortisone	Hydrocortisone/Placebo|Hydrocortisone Used as a Placebo	Hydrocortisone used as a placebo in comparative studies.(NCI)
C2569	Human_Papillomavirus_16_E7_Peptide-Padre_965_10	Human_Papilloma_Virus_Vaccine	Human Papillomavirus 16 E7 Peptide/Padre 965.10|HPV16 E7/PADRE 965.10|Lipidated HPV-16 E7/PADRE-965.10|Lipidated HPV-16 E7/Padre-965.10	A synthetic agent derived from human papillomavirus (HPV) E7 nuclear protein which is used to produce vaccines against HPV infection and HPV-related neoplasms.  HPV E7 oncogenic protein binds the retinoblastoma tumor suppressor protein, pRB, as well as a number of other cellular proteins, and serves as a transcriptional activator.  This protein is important in the induction and maintenance of cellular transformation and is co-expressed in the majority of HPV-containing carcinomas.  PADRE(R) is a proprietary family of molecules that enhances the immune systems response against an administered immunogen such as the HPV E7 nuclear protein. (NCI04)
C2570	Arginine_Butyrate	Immunostimulant	Arginine Butyrate|arginine butyrate	A substance that is being studied as a treatment for cancer.
C2571	Tocladesine	Differentiation_Inducer|Protein_Kinase_A_Inhibitor	Tocladesine|8-Chloro Cyclic AMP|8-Chloroadenosine Cyclic 3':5'-Monophosphate|8-Cl-cAMP|Adenazole|tocladesine	A substance that is being studied as an anticancer drug.  It is an analogue of a substance that occurs naturally in the body (cyclic adenosine monophosphate).
C2573	Murine_Monoclonal_Antibody_2B8	Monoclonal_Antibody	Murine Monoclonal Antibody 2B8|IDEC-2B8	A murine monoclonal antibody directed against the CD20 phosphoprotein, expressed on the cell surface of normal B-lymphocytes and B-cell lymphomas.(NCI)
C2574	Technetium_Tc_99m_Epratuzumab	Radioimmunoconjugate	Technetium Tc 99m Epratuzumab|Tc 99m LL2|Tc 99m Monoclonal Antibody LL2|Technetium Tc 99m LL2 Monoclonal Antibody|Technetium Tc 99m Monoclonal Antibody LL2	A radioimmunoconjugate comprised of a monoclonal antibody directed against CD22, a transmembrane glycoprotein expressed by B-cells, labelled with Technetium 99m.(NCI)
C2575	Fat_Emulsion	Miscellaneous_Adjuvant	Fat Emulsion|FAT EMULSION, INTRAVENOUS|Intralipid|Intravenous Fat Emulsion	A liquid composed of two immiscible substances, typically some form of fat and water. In parenteral nutrition, a fat emulsion may contain phospholipids, triglycerides and essential fatty acids (NCI04)
C2576	Dendritic_Cell-Recombinant_Prostate-Specific_Membrane_Antigen_Vaccine	Dendritic_Cell_Tumor_Peptide_Vaccine	Dendritic Cell-Recombinant Prostate-Specific Membrane Antigen Vaccine|CaPVax|Recombinant Prostate Specific Membrane Antigen-loaded Autologous Dendritic Cell Vaccine|rPSMA-loaded Autologous Dendritic Cell Vaccine	A vaccine comprised of autologous dendritic cells pulsed with a recombinant prostate specific membrane antigen. (NCI)
C2578	Low_Molecular_Weight_Heparin	Heparin	Low Molecular Weight Heparin|LMWH	Substances comprised of fragmented heparin molecules derived from unfractionated heparin that bind to antithrombin III with a molecular weight ranging from 1000 to 10,000 daltons, which causes changes in property from unfractionated heparin, including decreased protein binding, enhanced bioavailability, decreased platelet interaction, and decreased binding to thrombin.(NCI)
C2579	In_111_Ibritumomab_Tiuxetan	Radioimmunoconjugate	In 111 Ibritumomab Tiuxetan|IDEC In2B8|IDEC-In2B8|Indium In 111 Ibritumomab Tiuxetan|indium In 111 ibritumomab tiuxetan	A radiolabeled antibody that is being studied in cancer treatment.
C2580	SB_AS-2	Immunoadjuvant	SB AS-2	An agent containing the saponin QS21 and Monophosphoryl Lipid A in an oil-in-water emulsion for use as an adjuvant in Vaccine Therapy.(NCI)
C2581	Liothyronine_Sodium	Therapeutic_Triiodothyronine	Liothyronine Sodium|Cytomel|LIOTHYRONINE SODIUM|Triostat|liothyronine sodium	The sodium salt form of liothyronine, a synthetic thyroid hormone T3. (NCI)
C2582	Y_90_Humanized_Monoclonal_Antibody_LL2	Radioimmunoconjugate	Y 90 Humanized Monoclonal Antibody LL2|MOAB LL2, yttrium Y 90|Monoclonal antibody LL2, yttrium Y 90|Y 90 MoAb LL2|Y 90 monoclonal antibody LL2|Y90 Humanized Epratuzumab|Yttrium Y 90 Humanized Epratuzumab|Yttrium Y 90 Humanized Monoclonal Antibody LL2|yttrium Y 90 MOAB LL2	A radioimmunotherapeutic humanized murine monoclonal antibody (LL2) directed against the CD22 pan-B-cell antigen and chelated to the radioisotope yttrium-90 (Y 90).  Y 90 humanized monoclonal antibody LL2 binds to tumor cells expressing CD222, delivering a cytotoxic dose of beta radiation. (NCI04)
C2583	Rosiglitazone	Anti-diabetic_Agent|Differentiation_Inducer	Rosiglitazone Maleate|(+/-)-5-[[4-[2-(Methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-2,4-thiazolidinedione, ( Z )-2-Butenedioate (1:1)|Avandia|BRL49653|ROSIGLITAZONE MALEATE|Rosiglitazone|rosiglitazone	A drug taken to help reduce the amount of sugar in the blood. Rosiglitazone helps make insulin more effective and improves regulation of blood sugar. It belongs to the family of drugs called thiazolidinediones.
C2584	Epothilone_B_Analogue	Epothilone_Compound	Epothilone B Analogue	Analogues of epothilone B exhibiting antineoplastic activity.  Epothilone B analogues bind to tubulin and promote tubulin polymerization and microtubule stabilization, thereby inhibiting mitosis. (NCI)
C2585	Beriplast_P	Drug_Vehicle	Beriplast P	A sealant consisting of fibrin, an insoluble protein involved with blood clotting.  Fibrin forms a mesh around a wound area which dries and hardens, thereby forming a blood clot.  Beriplast-P is used to reduce surgical bleeding and has been used as a physiological tissue adherent drug carrier.(NCI)
C2586	Psoralen	DNA_Adduct_Forming_Agent|DNA_Crosslinking_Agent|Intercalating_Agent	Psoralen|PSORALEN|psoralen	A furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division.  Psoralen is used in Photochemotherapy or PUVA (Psoralen with high-intensity long-wavelength UVA irradiation). (NCI)
C2587	Progenipoietin	Immunoconjugate	Progenipoietin|Filgrastim-Fetal Liver Tyrosine Kinase-3 Fusion Protein|Flt-3 ligand/G-CSF fusion protein|ProGP|Progenipoetin|SD-9427	A recombinant, chimeric cytokine that exerts a variety of effects on the hematopoietic and immune systems.  Progenipoietin consists of portions of granulocyte colony-stimulating factor (G-CSF) and the ligand for human fetal liver tyrosine kinase-3 (FLT3).  When administered in vivo, both molecules have been shown to augment the number of circulating dendritic cell (DC) precursors. This agent also appears to be anti-apoptotic for some cell types. (NCI04)
C2588	Gadopentetate_Dimeglumine	Contrast_Agent	Gadopentetate Dimeglumine|Gd-DTPA|Magnevist	A gadolinium complex of diethylenetriamine pentaacetic acid with ionic paramagnetic properties. Gadopentetate dimeglumine may provide contrast enhancement during magnetic resonance imaging (MRI) of intracranial lesions with abnormal vascularity or of abnormalities in the blood-brain barrier (BBB). (NCI04)
C2589	Hypericum_Perforatum	Antineoplastic_Plant_Product	Hypericum Perforatum|St John's Wort|St. John's wort|St. Johns Wort|hypericum perforatum	An herbal preparation isolated from the plant St. John's Wort with photodynamic, antineoplastic, and antidepressant properties. Hypericin, one of the active compounds found in hypericum perforatum, is a photosensitizer that, when exposed to a particular wavelength and intensity of light, may induce tumor cell apoptosis. Another compound, hyperforin, induces caspase-dependent apoptosis in certain tumor cell lines.  Hypericum perforatum preparations may also stimulate the activity of cytochrome P450 enzymes and P-glycoprotein drug transporters, resulting in increased metabolism and decreased efficacy of various chemotherapeutic agents and other drugs. (NCI04)
C2590	Anti-Idiotype_Vaccine	Antineoplastic_Vaccine	Anti-Idiotype Vaccine|anti-idiotype vaccine	A vaccine made of antibodies that see other antibodies as the antigen and bind to it.  Anti-idiotype vaccines can stimulate the body to produce antibodies against tumor cells.
C2591	Benzaldehyde	Protein_Synthesis_Inhibitor	Benzaldehyde|BENZALDEHYDE|benzaldehyde	A color liquid aldehyde with an almond odor.  Benzaldehyde is found in many foods and is widely used in the chemical industry.  In the chemical industry, this agent is used in the preparation of various aniline dyes, perfumes, flavorings, and pharmaceuticals.  In addition, benzaldehyde has been associated with amygdalin (laetrile), since one of amygdalins breakdown products is benzaldehyde. (NCI)
C2592	Monoclonal_Antibody_M195	Monoclonal_Antibody	Monoclonal Antibody M195|MoAb M195	A murine IgG2a monoclonal antibody that targets CD33, a 67-kD cell surface glycoprotein expressed on myeloid leukemia cells. (NCI)
C2593	HER-2_neu_Intracellular_Domain_Protein	Vaccine_Adjuvant	HER-2/neu Intracellular Domain Protein	The carboxyl terminal autophosphorylation portion of the intracellular domain of HER2 for use in Vaccine Therapy.(NCI)
C2594	Autologous_Dendritic_Cells	Biological_Agent	Therapeutic Autologous Dendritic Cells	A population of a type of antigen-presenting cell (APC), the dendritic cell (DC), harvested from a patient and grown in vitro in the presence of tumor-associated antigens (TAAs) derived from the patient's tumor (a technique known as 'pulsing') and then injected back into the patient; autologous DCs so manipulated may stimulate a specific cell-mediated antitumoral cytotoxicity. DCs derived from a patient may also be fused with the patient's tumor cells in vitro to combine sustained tumor antigen expression with the antigen-presenting and immunostimulatory capacities of DCs; when injected back into the patient, these autologous DC-tumor cell hybrids (fusion cells) may stimulate an active antitumoral immune response.
C2595	Candida_Albicans_Skin_Test_Reagent	Diagnostic_Reagent	Candida Albicans Skin Test Reagent	A culture filtrate of cells of Candida Albicans propagated in a chemically defined medium and used as a recall antigen to evaluate cellular immunity in infection, cancer, and other disease states. (NCI)
C2596	MAGE-12_Peptide_Vaccine	Antineoplastic_Vaccine	MAGE-12 Peptide Vaccine	A vaccine comprised of a peptide from MAGE-12, a protein fraction expressed by melanoma, colorectal, breast, and non-small cell lung cancer, and sarcoma. (NCI)
C2597	Y_90_Monoclonal_Antibody_CC49	Radioimmunoconjugate	Y 90 Monoclonal Antibody CC49|Yttrium Y 90 Monoclonal Antibody CC49	A radioimmunoconjugate comprised of a monoclonal antibody directed against the tumor associated glycoprotein 72 (TAG-72), an antigen expressed on human breast, colorectal, and other carcinomas, labelled with Yttrium 90. (NCI)
C2598	Lutetium_Lu_177_Monoclonal_Antibody_CC49	Radioimmunoconjugate	Lutetium Lu 177 Monoclonal Antibody CC49|177 Lu-CC49	A radioimmunoconjugate comprised of a monoclonal antibody directed against the tumor associated glycoprotein 72 (TAG-72), an antigen expressed on human breast, colorectal, and other carcinomas, labelled with Lutetium 177. (NCI)
C2599	Interleukin-13_PE38QQR_Immunotoxin	Immunotoxin	Interleukin-13 PE38QQR Immunotoxin|IL 13-PE38QQR|IL-13 Toxin	A recombinant, chimeric protein with potent antitumor activity.  Interleukin-13 PE38QQR immunotoxin is composed of Interleukin-13 (IL-13), a pleiotropic immunoregulatory cytokine, linked to a mutated form of Pseudomonas Endotoxin A; this agent targets and kills tumor cells that express the IL-13 receptor. (NCI04)
C2600	Yttrium_Y_90_Daclizumab	Radioimmunoconjugate	Yttrium Y 90 Daclizumab|MOAB YT-90 Anti-TAC|Y90 Daclizumab|Y90 MOAB Anti-Tac	A synthetic radioimmunoconjugate comprised of a humanized anti-interleukin-2 (IL-2) antibody linked to the radioisotope Yttrium 90 with potential antineoplastic activity.  Daclizumab binds with high affinity to the Tac (also called CD25) subunit of the IL-2 receptor complex and inhibits the binding of IL-2, thereby blocking the IL-2-mediated activation of lymphocytes.  As Yttrium Y 90 daclizumab, daclizumab delivers radiation specifically to lymphocytes that express the IL-2 receptor. (NCI04)
C2601	Yttrium_Y_90_SMT_487	Radioimmunoconjugate	Yttrium Y 90-DOTA-Tyr3-Octreotide|OctreoTher|Yttrium Y 90 SMT 487|yttrium Y 90 SMT 487|yttrium Y 90-DOTA-tyr3-octreotide	A radiotherapeutic agent consisting of an analogue of the octapeptide octreotide (SMT 487) chelated to the radioisotope yttrium-90.  Yttrium Y 90-DOTA-tyr3-octreotide binds to somatostatin receptor-expressing tumor cells, selectively delivering a cytotoxic dose of beta radiation.
C2602	Carmustine_in_Ethanol	Nitrosourea_Compound	Carmustine in Ethanol|DTI-015	A formulation containing carmustine dissolved in ethanol for intra-tumoral administration that allows carmustine to enter both aqueous and lipid compartments of the target tissue.  As an antineoplastic nitrosourea, carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis.  Carmustine also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect.  Carmustine is highly lipophilic and crosses the blood-brain barrier readily.  (NCI)
C2603	Donepezil	Miscellaneous_Adjuvant	Donepezil Hydrochloride|Aricept|DONEPEZIL HYDROCHLORIDE|Donepezil|donepezil	A drug used in the treatment of Alzheimer's disease.  It belongs to the family of drugs called cholinesterase inhibitors.  It is being studied as a treatment for side effects caused by radiation therapy to the brain.
C2604	Iodine_I_131_Monoclonal_Antibody_muJ591	Radioimmunoconjugate	Iodine I 131 Monoclonal Antibody muJ591	A radioimmunoconjugate comprised of a monoclonal antibody directed against the external domain of the prostate specific membrane antigen (PSMA) labelled with Iodine 131. (NCI)
C2605	Beta_Alethine	Immunostimulant	Beta Alethine|Alethine|BetaLT|Betathine|N,N'-(Dithiodiethylene)bis(3-aminopropionamide)|beta alethine	A disulfide agent that stimulates T and B-cell functions and exhibits anti-tumor and immunostimulant activity. (NCI)
C2606	Monoclonal_Antibody_11D10_Anti-Idiotype_Vaccine	Anti-Idiotype_Vaccine	Monoclonal Antibody 11D10 Anti-Idiotype Vaccine|11D10 Anti-Idiotype Vaccine|TriAb|TriAb anti-idiotype antibody	A vaccine consisting of a monoclonal antibody (MoAB) directed against an idiotype that mimics a human milk fat globule (HMFG) membrane epitope.  Vaccination with monoclonal antibody 11D10 anti-idiotype vaccine induces anti-anti-idiotype antibodies (Ab3) that may react with breast cancer cell lines expressing the HMFG membrane epitope. (NCI04)
C2607	Yttrium_Y_90_Monoclonal_Antibody_BrE-3	Radioimmunoconjugate	Yttrium Y 90 Monoclonal Antibody BrE-3|MOAB BrE-3, Yttrium Y 90	A radioimmunotherapeutic agent consisting of a monoclonal antibody (BrE-3) directed against the tumor-associated antigen epithelial glycoprotein mucin chelated to the radioisotope yttrium-90.  Yttrium Y 90 monoclonal antibody BrE-3 binds to tumor cells expressing epithelial glycoprotein mucin, selectively delivering a cytotoxic dose of beta radiation. (NCI04)
C2608	In_111_Monoclonal_Antibody_BrE-3	Radioimmunoconjugate	In 111 Monoclonal Antibody BrE-3|Indium In 111 Monoclonal Antibody BrE-3	A humanized monoclonal antibody conjugated to the imaging radioisotope (indium-111). This radioimmunoconjugate binds to the breast epithelial mucin antigen, which is found primarily on breast cancer cells, permitting radioimmmuno-localization of mucin-positive tumor cells and an estimate of radiation dosimetry prior to administration of cytotoxic radiotherapy. (NCI04)
C2609	SS1_dsFv-PE38_Immunotoxin	Immunotoxin	SS1(dsFv)-PE38 Immunotoxin|Immunotoxin, SS1(dsFv)-PE38|SS1(dsFv) PE38	A recombinant immunotoxin consisting of the single chain anti-mesothelin monoclonal antibody SS1(dsFv) linked to Pseudomonas exotoxin PE-38. The monoclonal antibody moiety of the agent binds to cells that express mesothelin, a cell surface glycoprotein which may be overexpressed in ovarian cancer, mesotheliomas, and some squamous cell carcinomas; after internalization, the exotoxin moiety inactivates eukaryotic translation elongation factor 2, thereby disrupting tumor cell protein synthesis. (NCI04)
C2610	Monoclonal_Antibody_M170	Monoclonal_Antibody	Monoclonal Antibody M170	A panadenocarcinoma murine monoclonal antibody with potential antineoplastic activity.  Monoclonal antibody m170 may be conjugated with a radioactive element and used in radioimmunotherapy (RIT), a procedure that uses a tumor-specific monoclonal antibody to target radiation to cancer cells. (NCI04)
C2611	Monoclonal_Antibody_Mono-dgA-RFB4	CD22_Immunotoxin	Monoclonal Antibody Mono-dgA-RFB4|MONO dgA RFB4	An immunotoxin comprised of a monoclonal antibody directed against CD22, an antigen expressed on B lymphocytes, linked to a chemically deglycosylated ricin-A chain toxin. (NCI)
C2612	ESO-1_Peptide_Vaccine	Retired_Concepts	ESO-1 Peptide Vaccine	A cancer vaccine consisting of an immunogenic peptide sequence from the cancer-testis antigen ESO-1, an antigen found in normal testis and various tumors, including melanoma, breast, bladder, prostate, and hepatocellular cancers.  Vaccination with ESO-1 peptide vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte response against tumor cells that express ESO-1. (NCI04)
C2613	INS316	Diagnostic_Reagent	INS316|UTP Solution|Uridine 5-Triphosphate Solution	A short acting, inhaled P2Y2 receptor agonist used to stimulate lung mucociliary clearance. (NCI)
C2614	Yttrium_Y_90_Monoclonal_Antibody_B3	Radioimmunoconjugate	Yttrium Y 90 Monoclonal Antibody B3|90 Y-B3|MOAB B3, Yttrium Y 90|Y 90 Monoclonal Antibody B3|Y90-B3	A radioimmunoconjugate comprised of a monoclonal antibody directed against a carbohydrate antigen Le(Y), present on many human solid tumors, linked to Yttrium 90. (NCI)
C2615	In_111_Monoclonal_Antibody_B3	Radioimmunoconjugate	In 111 Monoclonal Antibody B3|111 In-B3|Indium In 111 Monoclonal Antibody B3	A radioimmunoconjugate comprised of a monoclonal antibody directed against a carbohydrate antigen Le(Y), present on many human solid tumors, linked to Indium 111. (NCI)
C2616	SMT-487	Growth_Hormone_Release_Inhibiting_Factor	SMT-487	A somatostatin peptide analog Tyr3-octreotide conjugated to tetra-azacyclododecanetetra-acetic acid (DOTA) that targets somatostatin receptors and is used in Radiotherapy.(NCI)
C2617	EGFR_Antisense_DNA	Phosphorothioate_Oligonucleotide	EGFR Antisense DNA	A synthetic sequence of DNA constructed in the antisense orientation to a sequence of DNA in epidermal growth factor receptor (EGFR), a member of the erbB gene family. EGFR antisense DNA suppresses the expression of EGFR by tumor cells, thereby inhibiting tumor cell proliferation and decreasing tumor growth.  This agent also appears to reduce the invasiveness of certain breast cancer cells. Members of the erbB gene family are overexpressed in many cancers and play roles in carcinogenesis and the regulation of cell proliferation. (NCI04)
C2618	Benzoylphenylurea	Tubulin_Binding_Agent	Benzoylphenylurea|BPU|BPU (Benzoylphenylurea)|benzoylphenylurea	A low molecular weight agent with antineoplastic activity. Benzoylphenylurea binds to the colchicine binding site on tubulin, thereby blocking tubulin polymerization and disrupting mitotic function.  This agent also inhibits DNA polymerase, and has been shown to arrest leukemia cells in the G1-S transition phase of the cell cycle. (NCI04)
C2619	Vaccinia-CEA-TRICOM_Vaccine	Vaccinia-TRICOM_Vaccine	Vaccinia-CEA-TRICOM Vaccine|rV-CEA(6D)/TRICOM	A vaccine consisting of recombinant vaccinia virus encoding the tumor-associated antigen carcinoembryonic antigen (CEA) and a triad of costimulatory molecules (B7-1, ICAM-1, and LFA-3; also called TRICOM).  Vaccination with vaccinia-CEA-TRICOM stimulates the host immune system to mount a T-cell response against tumor cells expressing the CEA antigen.  The use of TRICOM in the vaccine may elicit a greater antitumor cytotoxic T lymphocyte (CTL) immune response compared to the use of vaccinia-CEA alone. (NCI04)
C2620	Fowlpox-CEA-TRICOM_Vaccine	Fowlpox-TRICOM_Vaccine	Fowlpox-CEA-TRICOM Vaccine|fowlpox-CEA-B7.1/ICAM-1/LFA-3|rF-CEA(6D)TRICOM	A cancer vaccine comprised of a recombinant fowlpox virus vector encoding the carcinoembryonic antigen (CEA) and TRICOM. TRICOM is comprised of three co-stimulatory molecule transgenes (B7-1, ICAM-1 and LFA-3). This agent may enhance CEA presentation to antigen presenting cells (APC) and activate cytotoxic T-cells against CEA-expressing tumors. (NCI04)
C2621	Monoclonal_Antibody_ABX-CBL	Monoclonal_Antibody	Monoclonal Antibody ABX-CBL	A IgM murine monoclonal antibody that targets CD147, an antigen expressed by T-, B-, and Natural Killer (NK) cells, causing immunosuppression. (NCI)
C2622	CEA_571-579_Peptide	Vaccine_Antigen	CAP-1-6D|CEA:571-579 (576D)|CEA:571-579 (576D)[CAP1-6D]|Carcinoembryonic Antigen Peptide 1-6D	A 9-residue human leukocyte antigen (HLA)-restricted fragment of carcinoembryonic antigen (CEA). CEA:571-579 peptide, which has the amino acid sequence YLSGANLNL, may elicit a cytotoxic T lymphocyte (CTL) immune response against tumors expressing CEA. (NCI04)
C2623	NV1020	Oncolytic_Virus	NV1020	An oncolytic virus genetically engineered from the herpes simplex type 1 virus.
C2624	Bispecific_Antibody_4G7xH22	Bispecific_Monoclonal_Antibody	Bispecific Antibody 4G7xH22	A bispecific antibody containing a 4G7 hybridoma secreting IgG1 antibody specific for B-lymphocytes and a monoclonal antibody targeting Fc gamma RI-expressing cells.
C2625	Palivizumab	Monoclonal_Antibody	Palivizumab|Synagis	A humanized monoclonal antibody that targets the fusion protein (F protein) of respiratory syncytial virus (RSV), causing neutralization and fusion-inhibition activity against both type A and B RSV isolates.  Clinical Use: Respiratory Syncytial Virus-Prophylaxis.(NCI)
C2626	Huang_Lian	Antineoplastic_Plant_Product	Huang Lian|Coptis|Coptis Chinesis	A Chinese herb that has been used as a treatment for a variety of medical problems.  It is being studied as an anticancer drug.
C2627	GPI-0100	Vaccine_Adjuvant	GPI-0100	A semi-synthetic saponin that acts as an adjuvant in Vaccine Therapy and immune enhancer by stimulating Th1 immunity, causing synthesis of antigen-specific cytotoxic T-cells. (NCI)
C2628	MUC-2-Globo_H-KLH_Conjugate_Vaccine	Antineoplastic_Vaccine	MUC-2-Globo H-KLH Conjugate Vaccine	A vaccine comprised of MUC2, a cell surface antigen, and Globo H (Globo H Hexasaccharide 1), a tumor-associated complex carbohydrate antigen, conjugated with Keyhole Limpet Hemocyanin, an immunomodulator, that induces IgM and IgG antibodies and mediate complement dependent and/or antibody dependent cell mediated cytotoxicity. (NCI)
C2629	Valganciclovir	Nucleic_Acid_Synthesis_Inhibitor	Valganciclovir|Valcyte|valganciclovir	A synthetic prodrug of ganciclovir, a nucleoside analogue of 2'-deoxyguanosine, with antiviral activity. After phosphorylation, valganciclovir is incorporated into DNA, resulting in inhibition of viral DNA polymerase, viral DNA synthesis, and viral replication. (NCI04)
C2630	KSA-Interleukin-2_Fusion_Protein	Immunoconjugate	KSA-Interleukin-2 Fusion Protein|KSA-IL-2|KSA-interleukin-2	An immunoconjugate comprised of a monoclonal antibody targeting KSA, an epithelial cell adhesion molecule (Ep-CAM), fused to recombinant Interleukin-2, a cytokine that activates cytotoxic T-lymphocytes. (NCI)
C2631	Paclitaxel_Liposome	Paclitaxel	Paclitaxel Liposome|Liposome-Encapsulated Paclitaxel|PNU-93914	A liposome-encapsulated formulation of paclitaxel.  Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division.  This agent also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). (NCI)
C2632	Annamycin	Anthracycline_Antibiotic	Annamycin|annamycin	A lipophilic, anthracycline antineoplastic antibiotic. Annamycin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also circumvents multidrug-resistance (MDR) transporters, including p-glycoprotein. (NCI04)
C2633	AG2037	Glycinamide_Ribonucleotide_Formyltransferase_Inhibitor|Purine_Antagonist	AG2037	A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called glycinamide ribonucleotide formyl transferase inhibitors.
C2634	Digitoxin	Unclassified_Chemotherapy_Agent	Digitoxin|(3beta,5beta)-3-[(O-2,6-Dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-O-2,6-dideoxy-beta-D-ribo-hexopyranosyl-(1-4)-2,6-dideoxy-beta-D-ribo-hexopyranosyl)oxy]-14-hydroxycard-20(22)-enolide|CP4071	A lipid soluble cardiac glycoside that inhibits the plasma membrane sodium potassium ATPase, leading to increased intracellular sodium and calcium levels and decreased intracellular potassium levels.  In studies increased intracellular calcium precedes cell death and decreased intracellular potassium increase caspase activation and DNA fragmentation, causing apoptosis and inhibition of cancer cell growth. (NCI)
C2635	Pirfenidone	Nonsteroidal_Antiinflammatory_Drug|Radioprotective_Agent	Pirfenidone|pirfenidone	A substance that is being studied in the prevention and treatment of scar tissue caused by radiation therapy.  It belongs to the family of drugs called anti-inflammatory agents.
C2636	HPPH	Photosensitizing_Agent	HPPH|2-(1-Hexyloxyethyl)-2-Devinyl Pyropheophorbide-a|Photochlor	2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a.  A drug that is used in photodynamic therapy that is absorbed by tumor cells; when exposed to light, it becomes active and kills the cancer cells.
C2637	MVF-HER-2_628-647-CRL_1005_Vaccine	Antineoplastic_Vaccine	MVF-HER-2(628-647)-CRL 1005 Vaccine	A vaccine comprised of an engineered, chimeric HER-2 B-cell epitope [MVF-HER-2(638-647)] coated with a poloxamer (CRL-1005), a synthetic polymer, to form microparticles. (NCI)
C2638	MOv-gamma_Chimeric_Receptor_Gene	Transduction_Gene	MOv-gamma Chimeric Receptor Gene|MOv-gamma	A recombinant engineered chimeric gene derived from the murine gene encoding the variable region of monoclonal antibody MOv18 against folate-binding protein, which is often overexpressed in human ovarian cancer cells, and the gene encoding the Fc receptor for the gamma subunit of human IgG and IgE. Peripheral blood lymphocytes expressing the MOv-gamma gene may be used in the immunotherapeutic treatment of ovarian cancer. (NCI04)
C2639	Taurolidine	Miscellaneous_Antibiotic	Taurolidine|Taurolin|taurolidine	A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called anti-infectives.
C2640	Telomerase_540-548_Peptide_Vaccine	Antineoplastic_Vaccine	Telomerase: 540-548 Peptide Vaccine|Telomerase:540-548 Peptide	A recombinant peptide consisting of the amino acid residues 540 to 548 of the human telomerase reverse transcriptase (hTERT). Telomerase expression has been directly linked to tumor development; its catalytic subunit is expressed in the majority of human cancer cells, but infrequently in normal cells.  Vaccination with telomerase:540-548 peptide may stimulate cytotoxic T cells to recognize and kill telomerase-expressing cells. (NCI04)
C2641	TLK286	Mustard_Prodrug	TLK286	A modified glutathione analog. TLK286 is selectively activated by glutathione S-Transferase P1-1 into an alkylating metabolite which forms covalent linkages with nucleophillic centers in tumor cell DNA, thereby inducing a cellular stress response and cytotoxicity, and decreasing tumor proliferation. S-transferase P1-1 is an enzyme that is overexpressed in many human malignancies. (NCI04)
C2642	Phenoxodiol	Signal_Transduction_Inhibitor	Phenoxodiol|3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-ol|NV-06|phenoxodiol	A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called signal transduction inhibitors.
C2643	Trivalent_Influenza_Vaccine	Polyvalent_Vaccine	Trivalent Influenza Vaccine|FluMist|Flushield|Fluvirin|Fluzone|Influenza Vaccine	A synthetic vaccine consisting of three inactivated influenza viruses, two different influenza type A strains and one influenza type B strain.  Trivalent influenza vaccine is formulated annually, based on influenza strains projected to be prevalent in the upcoming flu season. This agent may be formulated for injection or intranasal administration. (NCI04)
C2644	Doxorubicin-Magnetic_Targeted_Carrier_Complex	Doxorubicin	Doxorubicin-Magnetic Targeted Carrier Complex|DOX-MTC|MTC-DOX	Anthracycline antineoplastic antibiotic doxorubicin bound to microscopic beads of activated carbon and iron (magnetic targeted carriers).  With placement of a magnet on the body surface overlying a tumor site, this carrier complex delivers doxorubicin directly to the tumor, thereby prolonging the duration of the therapeutic effects while decreasing its systemic toxicity.  Doxorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also produces toxic free-radical intermediates and interacts with cell membrane lipids causing lipid peroxidation. (NCI04)
C2645	Doxercalciferol	Vitamin_D_Analog	Doxercalciferol|(1alpha,3beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol|1-Alpha-Hydroxyvitamin D2|Hectorol|doxercalciferol	A substance that is being studied in the prevention of recurrent prostate cancer.  It belongs to the family of drugs called vitamin D analogs.
C2646	Tyrosinase-Related_Protein-2	Enzyme	Tyrosinase-Related Protein-2|TRP-2	A differentiation antigen expressed in many melanoma cell lines.  Peptides from this antigen are used in Vaccine Therapy to elicit an immune response.(NCI)
C2647	Methyl-5-Aminolevulinate	Photosensitizing_Agent	Methyl-5-Aminolevulinate|Metvix|methyl-5-aminolevulinate	A drug used in photodynamic therapy; it is absorbed by tumor cells and, when exposed to light, becomes active and kills the cancer cells.
C2648	Monoclonal_Antibody_105AD7_Anti-idiotype_Vaccine	Anti-Idiotype_Vaccine	Monoclonal Antibody 105AD7 Anti-idiotype Vaccine	A cancer vaccine consisting of a humanized monoclonal antibody that mimics a tumor-associated antigen 791Tgp72 (also known as CD55). Vaccination with this agent may stimulate a host cytotoxic T-cell response against tumor cells expressing CD55, resulting in tumor cell lysis. (NCI04)
C2649	DHA-Paclitaxel	Paclitaxel	DHA-Paclitaxel|DHA-paclitaxel|Docosahexaenoic Acid-Paclitaxel conjugate|TXP|Taxoprexin	A combination of DHA (a natural fatty acid) and paclitaxel (an anticancer drug) that is being studied as a treatment for cancer.
C2650	Synchrotope_TA2M_Plasmid_DNA_Vaccine	DNA_Vaccine	Synchrotope TA2M Plasmid DNA Vaccine	A vaccine comprised of a plasmid DNA encoding Synchrotope, a proprietary antigen discovery system, TA2M antigen. (NCI)
C2651	Silicon_Phthalocyanine_4	Photosensitizing_Agent	Silicon Phthalocyanine 4|Pc-4 (Silicone phthalocyanine)|Pc4	A synthetic photosensitizer agent containing a large macrocyclic ring chelated with silicon. Silicon phthalocyanine 4 localizes primarily in mitochondrial cytosolic membranes and, after photoexcitation, forms reactive oxygen species that induce apoptosis.
C2652	Monoclonal_Antibody_huJ591	Monoclonal_Antibody	Monoclonal Antibody huJ591	A humanized monoclonal antibody directed against the external domain of the prostate specific membrane antigen (PSMA) for use in Immunotherapy and Immunostaining. (NCI)
C2653	VNP40101M	Alkyl-Guanine_Transferase_Inhibitor|Miscellaneous_Alkylating_Agent	VNP40101M|1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazine	A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called alkylating agents.
C2654	Anti-Cytotoxic_T-Lymphocyte-Associated_Antigen-4_Monoclonal_Antibody	Monoclonal_Antibody	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody|MDX-010|MDX-010 (MDX-CTLA4)|MDX-CTLA4	A monoclonal antibody directed against cytotoxic T-lymphocyte-associated antigen-4 (CTLA4), an antigen that is expressed on activated T-cells and exhibits affinity for B7 co-stimulatory molecules. By binding CTLA4, anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody enhances T-cell activation and blocks B7-1 and B7-2 T-cell co-stimulatory pathways. (NCI04)
C2655	Iseganan_Hydrochloride	Cytoprotective_Agent|Radioprotective_Agent	Iseganan Hydrochloride|Iseganan HCl Oral Solution|Protegrin IB-367 Rinse|iseganan hydrochloride	A substance that is being studied as a treatment for oral mucositis (painful mouth sores) caused by cancer therapy.  It belongs to the family of drugs called synthetic protegrin analogs.
C2656	Halofuginone_Hydrobromide	Halofuginone	Halofuginone Hydrobromide|Halofuginone hydrobromide|RU 19110|Tempostatin|halofuginone hydrobromide	A quinazolinone alkaloid anticoccidial with potential antineoplastic activity.  Halofuginone hydrobromide inhibits type I collagen synthesis and matrix metalloproteinase 2 (MMP-2) gene expression, which results in the suppression of angiogenesis, tumor stromal cell development, and tumor cell growth. These effects appear to due to an effect of halofuginone on the activity of the MMP-2 promoter. (NCI04)
C2657	NY-ESO-1_Peptide_Vaccine	Antineoplastic_Vaccine	NY-ESO-1 Peptide Vaccine|ESO-1 Peptide Vaccine	A cancer vaccine consisting of an immunogenic peptide sequence from the cancer-testis antigen ESO-1, an antigen found in normal testis and various tumors, including melanoma, breast, bladder, prostate, and hepatocellular cancers.  Vaccination with ESO-1 peptide vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte response against tumor cells that express ESO-1. (NCI04)
C2658	Anti-CD3_x_anti-HER-2-neu_Bispecific_Monoclonal_Antibody	Bispecific_Monoclonal_Antibody	Anti-CD3 x anti-HER-2-neu Bispecific Monoclonal Antibody	A murine monoclonal antibody with two antigen-recognition sites: one for CD3, an antigen expressed on mature T cells, and one for HER-2-neu, a tumor-associated antigen that promotes tumor growth. This agent attaches to CD3-expressing T cells and HER-2-neu-expressing tumor cells, selectively cross-linking tumor and immunologic cells which results in the recruitment of cytotoxic T cells to the T cell/tumor cell aggregate. (NCI04)
C2659	Monoclonal_Antibody_CAL	Monoclonal_Antibody	Monoclonal Antibody CAL	A humanized monoclonal antibody directed against parathyroid hormone-related protein (PTH-rP). As a poly-hormone with diverse biological roles, PTH-rP is expressed by normal tissues, acting in local tissue environments in a variety of ways; it is commonly overexpressed by breast, prostate, and other cancers, acting systemically by promoting bone resorption, inhibiting calcium excretion from the kidney, inducing hypercalcemia, and possibly playing a role in the formation of bony metastases. By blocking the effects of PTH-rP on calcium metabolism, monoclonal antibody CAL may inhibit cancer-related hypercalcemia. (NCI04)
C2660	Tetanus_Toxoid	Vaccine_Adjuvant	Tetanus Toxoid|tetanus toxoid	A solution of formaldehyde-deactivated toxin isolated from the bacterium Clostridium tetani. Tetanus toxoid stimulates the production of antitoxin antibodies. This agent may be used as an adjuvant in cancer vaccines. (NCI04)
C2661	Herba_Scutellariae_Barbatae	Antineoplastic_Plant_Product|Miscellaneous_Adjuvant	Herba Scutellariae Barbatae|Ban Zhi Lian|Barbed Skullcap Herb|herba scutellaria barbatae	A Chinese herb isolated from the plant Scutellaria barbata D. Don (Lamiaceae) with potential antineoplastic activity.  Containing the antioxidant flavone scutellarin, herba scutellariae barbatae has been shown to induce apoptosis of ovarian and breast tumor cells in vitro. (NCI04)
C2662	XK469	Topoisomerase-II_Inhibitor	R(+)XK469|XK469	A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called topoisomerase II beta inhibitors.
C2663	Chinese_Herbs	Antineoplastic_Plant_Product	Chinese Herbs	Herbs used in Chinese Herbal Therapy for toxicity attenuation. (NCI)
C2664	Fibrin_Sealant	Miscellaneous_Adjuvant	Fibrin Sealant|TISSEEL|fibrin sealant	A plasma-derived fibrin sealant consisting of two separate components that are combined on application. One component is a concentrated solution of clottable fibrinogen; the other component is a thrombin solution containing CaCl2. When combined, the two preparations rapidly form a clot, reproducing the final stages of the coagulation cascade. (NCI04)
C2665	Edotecarin	Topoisomerase-I_Inhibitor	Edotecarin|6-N-(1-hydroxymethyla-2-hydroxy)ethylamino-12,13-dihydro-13-(beta-D-gluco pyranosyl)-5H-indolo[2,3-a]-pyrrolol[3,4-c]-carbazole-5,7(6H)-dione|J-107088	A substance that is being studied as a treatment for cancer.  It belongs to the family of drugs called topoisomerase I inhibitors.
C2666	Recombinant_Fowlpox-B7_1_Vaccine	Fowlpox_Virus_Vaccine	Recombinant Fowlpox-B7.1 Vaccine|rF-B7.1 Vaccine	A cancer vaccine comprised of a recombinant fowlpox virus vector encoding the stimulatory molecule transgene B7-1. Recombinant fowlpox-B7.1 vaccine may enhance antigen presentation and activate antitumoral cytotoxic T-cells. (NCI04)
C2667	Fowlpox-TRICOM_Vaccine	Fowlpox_Virus_Vaccine	Fowlpox-TRICOM Vaccine|rF-TRICOM (B7.1.iCAM1-LFA3-Fowlpox)	A cancer vaccine comprised of a recombinant fowlpox virus vector encoding TRICOM. TRICOM is comprised of three co-stimulatory molecule transgenes (B7-1, ICAM-1 and LFA-3) that may enhance antigen presentation and activate cytotoxic T-cells. Fowlpox adenovirus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells. (NCI04)
C2668	CC-5013	Endothelial_Cell_Inhibitor|Immunostimulant|Immunosuppressant	Lenalidomide|CC-5013|CC5013|Revlimid	A substance that is similar to thalidomide, and that prevents the growth of new blood vessels to solid tumors.  It belongs to the family of drugs called angiogenesis inhibitors.
C2669	Monoclonal_Antibody_Mik-Beta-1	Monoclonal_Antibody	Monoclonal Antibody Mik-Beta-1	A murine monoclonal antibody directed against the beta subunit of interleukin-2 receptor (IL-2R), expressed on resting T-lymphocytes, natural killer (NK) cells, and some leukemic cell types.  Monoclonal antibody Mik-Beta-1 prevents the binding of IL-2 to IL-2R beta, thereby inhibiting the IL-2-mediated proliferation and activation of T-cells. (NCI04)
C2670	CI-1040	Mitogen-Activated_Protein_Kinase_Inhibitor	CI-1040|PD 184352/CI-1040|PD-184352	An agent that inhibits both mitogen-activated protein kinase kinases 1 and 2 (MEK1 and MEK2), substrates of Raf and phosphorylates extracellular signal-regulated kinases 1 and 2 (ERK1 and ERK2), preventing phosphorylation and activation of the Mitogen-Activated Protein Kinase (MAPK) pathways, involved with signal transduction pathways and tumor proliferation.(NCI)
C2671	S-3304	Matrix_Metalloproteinase_Inhibitor	S-3304	An orally-agent agent with potential antineoplastic activity.  S-3304 inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. (NCI04)
C2672	Epothilone_D	Epothilone_Compound	Epothilone D|(4S-(4R*,7S,8R*,9R*,13Z,16R*(E)))-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-(1-methyl-2-(2-methyl-4-thiazolyl)ethenyl)oxacyclohexadec-13-ene-2,6-dione|12,13-Deoxyepothilone B|Desoxyepothilone B|KOS 862	A natural polyketide compound isolated from the myxobacterium Sorangium cellulosum. Also known as desoxyepothilone B, epothilone D binds to tubulin and inhibits the disassembly of microtubules, resulting in the inhibition of mitosis, cellular proliferation, and cell motility. (NCI04)
C2673	Clopidogrel_Bisulfate	Antiplatelet_Agent	Clopidogrel Bisulfate|CLOPIDOGREL BISULFATE|Plavix	A thienopyridine with antiplatelet activity. Clopidogrel bisulfate irreversibly alters the platelet receptor for adenosine diphosphate (ADP), thereby blocking the binding of ADP to its receptor, inhibiting ADP-mediated activation of the glycoprotein complex GPIIb/IIIa, and inhibiting fibrinogen binding to platelets and platelet adhesion and aggregation. (NCI04)
C2674	Vaccinia-GM-CSF_Vaccine	Vaccinia_Vaccine	Vaccinia-GM-CSF Vaccine	A vaccine comprised of a recombinant vaccinia virus encoding the gene for Granulocyte-Macrophage Colony-Stimulating Factor (Sargramostim, GM-CSF). (NCI)
C2675	Fowlpox-PSA_Vaccine	Fowlpox_Virus_Vaccine	Fowlpox-PSA Vaccine	A cancer vaccine consisting of a recombinant fowlpox virus encoding human prostate-specific antigen (PSA). Administration of this agent may stimulate a cytotoxic T cell response against PSA-expressing tumor cells. Fowlpox adenovirus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells. (NCI04)
C2676	G207	Oncolytic_Virus	G207	An oncolytic virus genetically engineered from the herpes simplex virus.
C2677	Magnetic-Targeted_Carriers	Drug_Vehicle	Magnetic-Targeted Carriers|MTC|magnetic-targeted carriers	Microparticles comprised of metallic iron and activated carbon used as a delivery vehicle for pharmaceutical agents.(NCI)
C2678	Beta-Glucan	Immunostimulant	Beta-Glucan|beta-glucan	A polysaccharide isolated from the cell walls of bacteria, plants, and fungi with immunostimulant and antineoplastic activities. In a solubilized form, beta-glucan binds to a lectin site within complement receptor 3 (CR3) on leukocytes, priming the receptor to trigger cytotoxic degranulation of leukocytes when leukocyte CR3 binds to complement 3 (iC3b)-coated tumors. Thus, the attachment of beta-glucan to CR3 of circulating leukocytes simulates leukocytes to kill iC3b-coated tumor cells in the same way as they kill iC3b-coated yeast. (NCI04)
C2679	ABT-751	Tubulin_Binding_Agent	ABT-751|E7010|N-[2-[(4-Hydroxyphenyl)amino]-3-pyridinyl]-4-methoxybenzenesulfonamide	A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called sulfonamides.
C2680	NA17_A2_Antigen	Tumor_Antigen	NA17.A2 Antigen	An adjunct antigen used in the development of vaccine therapy against tumor cells.
C2681	MAGE-10_A2	Tumor_Antigen	MAGE-10.A2	A synthetic nonapeptide derived from a melanoma-associated antigen. Vaccination with MAGE-10.A2 may stimulate a host cytotoxic T-cell response against tumor cells that express the melanoma-associated antigen, resulting in tumor cell lysis. (NCI04)
C2682	VEGF_Trap	Angiogenesis_Activator_Inhibitor	VEGF Trap|VEGF Trap R1R2|Vascular Endothelial Growth Factor Trap	A protein comprised of segments of the extracellular domains of human vascular endothelial growth factor receptors 1 (VEGFR1) and 2 (VEGFR2) fused to the constant region (Fc) of human IgG1.  VEGF trap binds to vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor, thereby preventing VEGF from binding to its cell receptors.  Disruption of this cell receptor binding results in the inhibition of angiogenesis and metastasis, and tumor regression. (NCI04)
C2683	Monoclonal_Antibody_D6_12	Monoclonal_Antibody	Monoclonal Antibody D6.12	A murine monoclonal antibody directed against the Mr 48,000 antigen expressed on the cell surface of normal and malignant gastrointestinal epithelium, resulting in antibody-dependent cell-mediated cytotoxicity. (NCI)
C2684	Monoclonal_Antibody_C-58	Monoclonal_Antibody	Monoclonal Antibody C-58	A human IgM monoclonal antibody directed against human Cytomegalovirus. (NCI)
C2685	Vaccinia-TRICOM_Vaccine	Vaccinia_Vaccine	Vaccinia-TRICOM Vaccine|Vaccinia-TRICOM|rV-TRICOM	A vaccine consisting of recombinant vaccinia virus encoding a triad of costimulatory molecules (B7-1, ICAM-1, and LFA-3; also called TRICOM).  Vaccination with vaccinia-TRICOM stimulates the host immune system to mount a non-specific T-cell response.  With the addition of a tumor-associated antigen peptide, this vaccine may enhance a tumor-specific immune response. (NCI04)
C2686	Fowlpox-Sargramostim	Fowlpox_Virus_Vaccine	Fowlpox-Sargramostim Vaccine|Fowlpox-GM-CSF|Fowlpox-Sargramostim|GM-CSF - Fowlpox	A cancer vaccine consisting of a recombinant fowlpox virus encoding human granulocyte-macrophage colony-stimulating factor (GM-CSF). GM-CSF binds to specific cell surface receptors on various immuno-hematopoietic cell types, enhancing their proliferation and differentiation and stimulating macrophage and dendritic cell functions in antigen presentation and antitumor cell-mediated immunity. Administration of fowlpox-sargramostim may induce an immune response against tumor cells. Fowlpox adenovirus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells. (NCI04)
C2687	Visilizumab	Monoclonal_Antibody	Visilizumab|Nuvion|visilizumab	A humanized anti-CD3 monoclonal antibody targeting activated T-cells, inducing apoptosis. (NCI)
C2688	ABI-007	Paclitaxel	ABI-007|Abraxane|Albumin-Stabilized Nanoparticle Paclitaxel|Nanoparticle Paclitaxel	A Cremophor ELP-free, albumin-stabilized nanoparticle formulation of the natural taxane paclitaxel with antineoplastic activity. Paclitaxel binds to and stabilizes microtubules, preventing their depolymerization and so inhibiting cellular motility, mitosis, and replication. This formulation solubilizes paclitaxel without the use of Cremophor ELP and permits the administration of larger doses of this agent, which would be toxic in a Cremophor ELP-containing formulation due to Cremophor ELP's toxicity profile. Cremophor ELP is a nonionic solubilizer made by reacting castor oil with ethylene oxide in a molar ratio of 1:35, followed by a purification step. (NCI04)
C2689	IH636_Grape_Seed_Proanthocyanidin_Extract	Cardioprotective_Agent|Cytoprotective_Agent	IH636 Grape Seed Proanthocyanidin Extract|ActiVin|GSPE	An oligomeric proanthocyanidin extracted from grape seeds.  IH636 grape seed proanthocyanidin extract exhibits dose-dependent free-radical scavenging and antioxidant properties.
C2690	Sho-Saiko-To	Antineoplastic_Plant_Product	Sho-Saiko-To|Keisho-To|Minor Bupleurum Formula|TJ-9|Xiao Chai Hu Tang|Xiao-Chai-Hu-Tang	A formulation containing seven chinese herbs with Baicalein, a flavone, the principal component exhibiting hepatoprotective, antiproliferative, and immunostimulatory properties. (NCI)
C2691	Ginger	Antiemetic_Agent|Chemopreventive_Agent	Ginger|Zingiberis rhizoma (Hot Water Extract)	A rhizome herb isolated from the plant Zingiber officinale with potential antineoplastic activity. Ginger contains a number of different phenolic compounds, some of which have displayed antineoplastic, anti-inflammatory, and antioxidant activities.  This agent also exhibits antiemetic properties. (NCI04)
C2692	Glycinamide_Ribonucleotide_Formyltransferase_Inhibitor	Enzyme_Inhibitor	Glycinamide Ribonucleotide Formyltransferase Inhibitor|glycinamide ribonucleotide formyltransferase inhibitors	A family of drugs that block DNA synthesis and may prevent tumor growth. They are being studied as a treatment for cancer.
C2693	Erlotinib	Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor	Erlotinib|CP-358,774|Cp-358,774|Erlotinib Hydrochloride|N-(3-Ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine Monohydrochloride|OSI 774|OSI-774|Tarceva|erlotinib	A quinazoline derivative with antineoplastic properties.  Competing with adenosine triphosphate, erlotinib reversibly binds to the intracellular catalytic domain of epidermal growth factor receptor (EGFR) tyrosine kinase, thereby reversibly inhibiting EGFR phosphorylation and blocking the signal transduction events and tumorigenic effects associated with EGFR activation. (NCI04)
C2694	Green_Tea_Extract	Chemopreventive_Agent	Green Tea Extract|Green Tea Polyphenols|Tea, Green Extract|Tea, Green, Polyphenols	A defined, decaffeinated green tea polyphenol mixture isolated from Camellia sinensis, a plant native to Asia, with antiviral and antioxidant activities and potential chemopreventive activity. Green tea extract contains antioxidant compounds, including flavonoids, vitamins and polyphenols such as epigallocatechin-3-gallate (EGCG), which may have antineoplastic properties. Consumption of green tea extract may confer chemopreventive protection against various cancers including those of the prostate, stomach, and esophagus.
C2695	Epoetin_Alfa	Recombinant_Erythropoietin	Epoetin Alfa|EPO|Epogen|Procrit|epoetin alfa	A colony-stimulating factor that is made in the laboratory. It increases the production of red blood cells.
C2696	I_131_Lipiodol	Radioconjugate	I 131 Lipiodol|Iodine I 131 Lipiodol|Lipiocis	A cytotoxic radioconjugate consisting of lipiodol, an iodinated ethyl ester derived from poppy seed oil, labeled with iodine 131 (I-131).  I-131 Lipiodol accumulates in hepatocellular carcinoma and hepatoblastoma tumor cells, resulting in targeted cytotoxicity to tumor cells while sparing surrounding normal cells and tissues. (NCI04)
C2697	Iodine_I_131_Monoclonal_Antibody_CC49-deltaCH2	Radioimmunoconjugate	Iodine I 131 Monoclonal Antibody CC49-deltaCH2|131I-HuCC49-deltaCH2|131I-MOAB CC49-deltaCH2|I131 MOAB CC49-deltaCH2	A humanized CH2 domain deleted monoclonal antibody CC49 that reacts with Tumor-Associated Glycoprotein (TAG)-72 with superior tumor-targeting than the parent, Monoclonal Antibody CC49, linked to Iodine 131. (NCI)
C2698	Monoclonal_Antibody_CC49-delta_CH2	Monoclonal_Antibody	Monoclonal Antibody CC49-delta CH2|MOAB CC49-deltaCH2	A humanized CH2 domain deleted monoclonal antibody CC49 that reacts with Tumor-Associated Glycoprotein (TAG)-72, a human pancarcinoma antigen, with superior tumor-targeting than the parent, Monoclonal Antibody CC49, for use in Radiotherapy.
C2699	Enzyme_Catalyzed_Therapeutic_Activation_Agent	Multidrug_Resistance_Modulator	Enzyme Catalyzed Therapeutic Activation Agent|ECTA Agent|Enzyme Catalyzed Therapeutic Activation Compound	Prodrugs that are released by a cells drug resistance enzyme to the active form, causing cell death with decreased toxicity.(NCI)
C2700	Human_Thymosin-Fraction_5	Recombinant_Thymosin	Human Thymosin-Fraction 5|Thymosin Fraction 5	A partially purified preparation isolated from the thymus and containing several peptides. Human Thymosin-Fraction 5 (TF-5) possesses immunopotentiating properties and can correct many of the immunological deficiencies resulting from the lack of thymosin function in animal models and in humans. This agent enhances the spontaneous natural killer activity of normal human large granular lymphocytes; exhibits additive effects with recombinant IFN-alpha in enhancing natural killer activity in vitro and; enhances IL2 production, IL2 receptor expression, and IFN-gamma production in mitogen-stimulated large granular lymphocytes. TF-5 may also modulate the secretion of some hypothalamic peptides and pituitary hormones, including prolactin and growth hormone. (NCI04)
C2701	Therapeutic_Immune_Globulin	Biological_Agent|Biological_Response_Modifier	Recombinant Immune Globulin|BayGam|Gamimune N|Gammagard S/D|Gammar-P|IgIV|Immune Globulin IV|Immune Globulin Intravenous|Iveegam EN|Panglobulin|Polygam S/D|Sandoglobulin|Therapeutic Immune Globulin|Therapeutic Immunoglobulin|Venoglobulin-I|Venoglobulin-S|WinRho SDF	A preparation of plasma proteins derived from the pooled plasma of adult donors. Largely comprised of IgG antibodies,  therapeutic immune globulin provides passive immunization by increasing the recipient's serum levels of circulating antibodies.  IgG antibodies have multiple functions, including binding to and neutralizing bacterial toxins; opsonization of pathogens; activation of complement; and suppression of pathogenic cytokines and phagocytes through binding to CD5, interleukin-1a (IL-1a), interleukin 6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and T-cell receptors.  Therapeutic immune globulin may diminish pathogenic mechanisms in some autoimmune diseases by binding to and inhibiting the activity of autoantibodies. (NCI04)
C2702	Vincristine_Sulfate_Liposomes	Vincristine_Sulfate	Vincristine Sulfate Liposomes	A liposome-encapsulated formulation of Vincristine Sulfate. (NCI)
C2703	Mistletoe_Extract	Miscellaneous_Biologic_Response_Modifier	Mistletoe Extract|Abnobaviscum|Apotheker Bauer's Misteltinktur|Cefalektin|Eurixor|Helixor|Iscador|Isorel|Isugran|Lektinol|Mistel Curarina|Mistel- Krautertabletten|Mistelol-Kapseln|Plenosol N|Viscum|Viscysat|mistletoe lectin	A substance that comes from the mistletoe plant and that is being studied as a treatment for cancer.  A lectin is a complex molecule that has both protein and sugars. Lectins are able to bind to the outside of a cell and cause biochemical changes in it. Lectins are made by both animals and plants.
C2704	Fixative_Stain	Conceptual_Entities	Fixative/Stain|FIX/ST	A compound that both fixes tissues or cells and stains it for microscopic study.
C2705	Tag	Retired_Concepts	Tag
C2706	Anthrapyrazole	Anthrapyrazole_Antibiotic	Anthrapyrazole|Anthra[1, 9-cd]pyrazol-6(2H)-one, 7, 10-dihydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-(methylamino )ethyl]amino]-acetate (salt) hydrobromide (10:5:21)|Anthra[1, 9-cd]pyrazol-6(2H)-one, 7, 10-dihydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-(methylamino )ethyl]amino]-acetate (salt) hydrobromide(10:5:21)|Anthra[1,9-cd]pyrazol-6(2H)-one, 7, 10-dihydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-(methylamino )ethyl]amino]-, acetate (salt) hydrobromide (10:5:21)|Anthra[1,9-cd]pyrazol-6(2H)-one, 7, 10-dihydroxy-2-[2-[(2-hydroxyethyl)amino]ethyl]-5-[[2-(methylamino )ethyl]amino]-, acetate (salt) hydrobromide(10:5:21)	An antineoplastic antibiotic that intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  Anthrapyrazoles may also block cell cycle division.  In the presence of electron donors, some anthrapyrazole antibiotics cause single-strand breaks in DNA via photosensitization by visible light.  These agents are less cardiotoxic than doxorubicin. (NCI04)
C2707	DHEA_Mustard	Nitrogen_Mustard_Compound	DHEA Mustard|Dehydroepiandrosterone mustard|dehydroepiandrosterone mustard	A steroidal alkylating agent with potential antineoplastic activity.  Alkylating agents exert cytotoxic and, in some cases, chemotherapeutic effects by transferring alkyl groups to DNA, thereby damaging DNA and interfering with DNA replication and cell division. (NCI04)
C2708	Curcumin_C3_Complex	Antioxidant	Curcumin C3 Complex|Curcuminoids	A mixture composed of curcuminoid phenols extracted from the plant Curcuma longa (turmeric root) with potent antioxidant and anti-inflammatory properties.  Curcumin C3 complex is a unique combination of three phenols: curcumin, demethoxycurcumin and bisdemethoxycurcumin.  This agent may both prevent the formation of free radicals and neutralize free radicals.  Curcuminoids may have chemopreventive and antiproliferative properties. (NCI04)
C2709	Anti-idiotype_MUC-1_Monoclonal_Antibody	Monoclonal_Antibody	Anti-idiotype MUC-1 Monoclonal Antibody|Anti-idiotype MUC-1	A monoclonal antibody that functionally mimics MUC-1 antigen, a tumor cell surface antigen.  Administration of anti-idiotype MUC-1 monoclonal antibody may elicit an anti-idiotype antibody and corresponding T-cell response against MUC-1 expressing tumor cells. (NCI)
C2710	CEA_RNA-pulsed_Autologous_Human_Cultured_Dendritic_Cells	Autologous_Dendritic_Cells	CEA RNA-pulsed Autologous Human Cultured Dendritic Cells	Autologous human dendritic cells pulsed with RNA encoding the carcinoembryonic antigen (CEA) are being studied for possible use in the treatment of cancer expressing CEA.
C2711	Combretastatin_A-4	Tubulin_Binding_Agent	Combretastatin A-4	An inhibitor of microtubule polymerization derived from the South African willow bush which causes mitotic arrest and selectively targets and reduces or destroys existing blood vessels, causing decreased tumor blood supply.
C2712	Monoclonal_Antibody_E7_6_3	Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor|Monoclonal_Antibody	Monoclonal Antibody E7.6.3|E7.6.3|Human IgG2K Monoclonal Antibody|MoAb E7.6.3	A human IgG2kappa monoclonal antibody specific for the epidermal growth factor (EGF) receptor.  Monoclonal antibody E7.6.3 binds to the EGF receptor (EGFr), blocking the binding of epidermal growth factor and transforming growth factor alpha to EGFr-expressing cancer cells and ultimately inhibiting EGFr-dependent cell activation and proliferation. (NCI)
C2713	EKB-569	Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor	EKB-569|EKB 569	A 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity.  EKB-569 irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors. (NCI05)
C2714	EMD_55900	Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor|Monoclonal_Antibody	EMD 55900|EMD 55 900|Monoclonal Antibody 425	A murine monoclonal antibody targeting the epidermal growth factor receptor (EGFR) exhibiting anti-tumor activity.  EMD 55900 binds to the EGFR, thereby inhibiting ligand-mediated receptor activation and ultimately impaired cell growth and proliferation. (NCI)
C2715	FJ5002	Telomerase_Inhibitor	FJ5002	A derivative of rhodacyanine with potential antineoplastic activity.  FJ5002 inhibits telomerase by interfering with holoenzyme assembly and telomere interaction, thus leading to replication-dependent shortening of telomeres with a concurrent increase in aneuploid metaphases and apoptotic cells.  Telomerase is active in most tumors cells, but is quiescent in adjacent normal cells. (NCI04)
C2716	Monoclonal_Antibody_GW2016	Retired_Concepts	Monoclonal Antibody GW2016|GW2016|MoAb GW2016
C2717	HER_Peptides	Vaccine_Adjuvant	HER Peptides
C2718	Poly_Microsphere_Encapsulated_HER2_neu_Oral_Vaccine	Antineoplastic_Vaccine	Poly Microsphere Encapsulated HER2/neu Oral Vaccine|Poly Microsphere Encapsulated HER2/neu Derived p365-377 Peptide Oral Vaccine	A cancer vaccine consisting of Her2/neu peptides incorporated into microspheres of poly (lactide-co-glycolide) (PLGA), a biodegradable polymer.  Poly microsphere encapsulated HER2/neu oral vaccine has been investigated for use in immunotherapy for tumors positive for HER-2/neu, a tumor associated antigen that is overexpressed in various cancers, including breast and ovarian cancer. (NCI04)
C2719	HuMV833	Angiogenesis_Activator_Inhibitor|Monoclonal_Antibody	Monoclonal Antibody HuMV833|HuMV833|MoAb HuMV833	A humanized monoclonal antibody directed against vascular endothelial growth factor (VEGF), a pro-angiogenic cytokine.  HuMV833 has been shown to decrease the permeability of blood vessels that supply tumors, an effect which may lead to slowed tumor growth. (NCI04)
C2720	Monoclonal_Antibody_ICR62	Monoclonal_Antibody	Monoclonal Antibody ICR62|ICR62	A rat monoclonal antibody that inhibits Epidermal Growth Factor Receptor (EGFR), targeting tumor cells expressing the wild-type EGFR and EGFRvIII. (NCI)
C2721	ISIS_5132	Phosphorothioate_Oligonucleotide	ISIS 5132|CGP 69846A|CGP69846A|ISIS 5132/CGP69846A|ISIS-5132|RAF-IK Antisense ODN|c-RAF Antisense	A substance that is being studied in the treatment of cancer.
C2722	L-779450	Raf_Kinase_Inhibitor	L-779450|L-779,450	A synthetic triarylimidazole with potential antineoplastic activity.  As a Raf kinase inhibitor, L-779450 competes with ATP for binding to the Raf-1 and A-Raf catalytic sites, thus inhibiting their enzymatic activities and blocking various signal transduction pathways that depend on Raf-1 kinase (particularly the Ras-Raf-MEK-ERK cascade which is often up-regulated in neoplasms). (NCI04)
C2723	MAGE-12_170-178_Peptide	Vaccine_Antigen	MAGE-12: 170-178 Peptide|MAGE-12: 170-178|MAGE-12: 170-178 peptide	A synthetic peptide consisting of the amino acids 170 through 178 of the MAGE-12 melanoma antigen.  MAGE-12 170-178 has been identified as an epitope recognized by tumor infiltrating lymphocytes (TIL).  Vaccination with MAGE-12 170-178 stimulate the host immune system to mount a TIL response against tumor cells expressing MAGE-12, potentially resulting in decreased tumor growth. (NCI04)
C2724	MS-275	Histone_Deacetylase_Inhibitor	MS-275	A substance that is being studied in the treatment of cancers of the blood. It belongs to the family of drugs called histone deacetylase inhibitors.
C2725	Monoclonal_Antibody_CO17-1A	Monoclonal_Antibody	Monoclonal Antibody CO17-1A|Mab CO17-1A|MoAb CO17-1A	A murine IgG2 monoclonal antibody against the tumor-associated antigen 17-1A.  Adminstration of monoclonal antibody CO17-1A (Mab C017-1A) elicits an antibody-dependent cell-mediated cytotoxicity.  In addition, Mab C017-1A has preclinically acted as an immunogen for development of anti-idiotypic antibody BR3E4. (NCI)
C2726	Monoclonal_Antibody_B3	Monoclonal_Antibody	Monoclonal Antibody B3|B3	A murine IgG1 monoclonal antibody directed against Lewis Y antigen and related carbohydrate antigens of cell surface glycoproteins found in many tumor cells.  Monoclonal antibody B3 can be conjugated with various toxins in order to target their cytotoxic activity to tumor cells expressing these carbohydrate antigens. (NCI04)
C2727	PD-168393	Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor|Signal_Transduction_Inhibitor	PD-168393|4-[(3-Bromophenyl)amino]-6-Acrylamidoquinazoline|PD 168 393	A cell permeable monoclonal antibody that irreversibly and selectively inhibits epidermal growth factor receptor (EGFr) tyrosine kinase activity.  PD-168393 binds to the catalytic domain of EGFr, thereby blocking the binding of epidermal growth factor (EGF) to EGF receptors and potentially inhibiting EGFr-expressing tumor cell growth. (NCI)
C2728	Polyclonal_Vaccine	Vaccine	Polyclonal Vaccine	A class of vaccines consisting of multiple antigens conjugated an immunostimulant, keyhole limpet hemocyanin (KLH), QS21 or gp-100. (NCI)
C2729	Radiolabeled_CC49	Radioimmunoconjugate	Radiolabeled CC49
C2730	Mutated_Ras_Peptide	Vaccine_Antigen	Mutated Ras Peptide|Ras Peptides (mutated)	Point-mutation products of Ras proto-oncogene are found to associated with a broad spectrum of human carcinomas.  Mutation locations are notably at codons 12, 13, and 61. Codon 12 mutations form more than 90% of all Ras mutations in human cancers.  Degraded Ras peptides have been shown to stimulate immunogenic response.  Various forms of mutated Ras peptides-adjuvant are used as vaccine along with cytokines that could potentially enhance the body's immunological response in many neoplastic conditions. (NCI04)
C2731	Rhodacyanine	Photosensitizing_Agent|Rhodamine	Rhodacyanine|1-Ethyl-2-[[-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]pyridinium Chloride|1-ethyl-2-[3-ethyl-5-(3-methylbenzothiazolin-2-yliden)-4-oxothiazolidin-2-ylidenemethyl] pyridinium chloride|FJ 776|MKT-077
C2732	rV-MUC-1_Vaccine	Vaccinia_Vaccine	Recombinant Vaccina V-MUC-1 Vaccine|Recombinant Vaccinia MUC-1|rV-MUC-1 Vaccine	A vaccine containing a recombinant vaccinia virus that encodes the gene for human mucin-1, a tumor-associated antigen. Upon administration, recombinant vaccinia-MUC-1 vaccine may elicit a MUC-1-specific cytotoxic T cell response against tumor cells bearing MUC-1.
C2733	TheraCim_hR3	Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor|Monoclonal_Antibody|Photosensitizing_Agent	TheraCim hR3|Nimotuzumab|Thera-CIM-hr3|Theraloc	A humanized monoclonal antibody exhibiting anti-cancer activity.  TheraCIM hR3 targets the epidermal growth factor receptor (EGFr), resulting in EGFr-overexpressing cancer cell growth inhibition.  In addition, this agent acts synergistically with radiation therapy. (NCI)
C2734	Vitaxin-2	Endothelial-Specific_Integrin-Survival_Signaling_Inhibitor|Monoclonal_Antibody	Vitaxin-2|Monoclonal Antibody Anti-Avb3 Integrin|Vitaxin 2	A modified version of Vitaxin, a humanized monoclonal IgG1 antibody to alpha(v)beta(3)integrin.  Exhibiting improved affinity to alpha(v)beta(3)integrin compared to first-generation Vitaxin, Vitaxin-2 blocks the binding of ligands, such as vitronectin, to alpha(v)beta(3) integrin, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. (NCI04)
C2735	Y_90_Anti-CEA_Monoclonal_Antibody	Radioimmunoconjugate	Y 90 Anti-CEA Monoclonal Antibody|Y90 Anti-CEA Monoclonal Antibody|Yttrium Y90 Anti-CEA monoclonal antibody	A radioimmunoconjugate consisting of a monoclonal antibody directed against carcinoembryonic antigen (CEA), linked to a beta-emitting radioisotope yttrium-90 (Y-90).  Y-90 Anti-CEA monoclonal antibody binds to tumor cells that express CEA, delivering beta particle radiation.
C2736	ZD-6126	Endothelial_Cell_Inhibitor	ZD-6126|ANG453|N-[(5S)-6,7-Dihydro-9,10,11-trimethoxy-3-(phosphonooxy)-5H-dibenzo[a,c]cyclohepten-5-yl]acetamide|N-acetylcochinol-O-phosphate|ZD6126	A water-soluble phosphate prodrug of N-acetylcolchinol with potential antineoplastic activity.  ZD-6126 binds to and destabilizes the tubulin cytoskeleton of endothelial cells, thereby inhibiting angiogenesis which may result in tumor necrosis. (NCI04)
C2737	ZD-6474	Angiogenesis_Activator_Inhibitor|Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor	ZD-6474|AZD6474|Vandetanib|ZD6474	An orally bioavailable 4-anilinoquinazoline.  ZD-6474 selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGF2), thereby blocking VEGF-stimulated endothelial cell proliferation and migration and reducing tumor vessel permeability.  This agent also blocks the tyrosine kinase activity of epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that mediates tumor cell proliferation and migration and angiogenesis.  (NCI04)
C2738	Isoxazole_Urea	Retired_Concepts	Isoxazole Urea
C2739	Monoclonal_Antibody_7C11	Monoclonal_Antibody	Monoclonal Antibody 7C11|MoAb 7C11|MoAb IMC-7C11	A monoclonal antibody targeting fas, membrane proteins that transduce apoptic signals.  As an anti-Fas monoclonal antibody, monoclonal antibody 7C11 (MoAb 7C11) induces apoptosis of Fas-expressing cells.  In addition, anti-fas MoAb 7C11-induced apoptosis has been associated with activation of stress-activated protein kinase. (NCI)
C2740	VHL16	Von_Hippel-Lindau_Peptide_Vaccine	VHL16 Peptide|(S111I) VHL16|S111I	A peptide vaccine derived from the von Hippel-Lindau (VHL) tumor suppressor protein, a general transcription factor. VHL16 peptide, also known as S111I, is a point mutation variant of the VHL tumor suppressor protein; the mutation is in amino acid position 111.  Vaccination with this agent may stimulate a cytotoxic T-cell response in patients with VHL-associated cancers that express this variant of the VHL tumor suppressor protein. (NCI04)
C2741	VHL14	Von_Hippel-Lindau_Peptide_Vaccine	VHL14 Peptide|(V166A) VHL14|Berzofsky VHL Peptide|Berzofsky VHL Peptide (CLQVARSLVK)|V166A|VHL14	A peptide vaccine derived from the von Hippel-Lindau (VHL) tumor suppressor protein, a general transcription factor.  VHL14 peptide is a point mutation variant of the VHL protein; the mutation is in amino acid position 166.  It might be used to elicit or boost cellular immunity to cancers that expressing the von Hippel-Lindau mutation. (NCI04)
C2742	ALVAC-B7-CEA	ALVAC-CEA_Vaccine	ALVAC-B7-CEA	A cancer vaccine consisting of ALVAC, a highly attenuated poxvirus strain derived from the canarypox virus.  ALVAC-B7-CEA expresses carcinoembryonic antigen (CEA), a protein that is overexpressed by many tumor cells, and B7.1 (also known as CD80), the natural ligand for the T-cell antigen CD28, to augment the host immune response.  This agent has been shown to stimulate a host immune response against tumor cells that express CEA. (NCI04)
C2743	ALVAC-CEA_VCP248	ALVAC-CEA_Vaccine	ALVAC-CEA (VCP248)	A replication-defective recombinant canarypox virus (ALVAC) that contains the entire human carcinoembryonic antigen (CEA) gene.  Vaccination with ALVAC-CEA (VCP248) may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against CEA-positive tumor cells, thereby decreasing tumor growth. (NCI04)
C2744	Atropine_Sulfate	Antimuscarinic_Agent	Atropine Sulfate|ATROPINE SULFATE	The sulfate salt of atropine, a naturally-occurring alkaloid isolated from the plant Atropa belladonna.  Atropine functions as a sympathetic, competitive antagonist of muscarinic cholinergic receptors, thereby abolishing the effects of parasympathetic stimulation.  This agent may induce tachycardia, inhibit secretions, and relax smooth muscles. (NCI04)
C2745	B7_Transfected_Melanoma_Cell_Vaccine	Melanoma_Vaccine	B7 Transfected Melanoma Cell Vaccine|B7 Transfected Allogenic Melanoma Cell Vaccine	An allogenic whole tumor cell vaccine with potential antineoplastic activity.  B7 transfected melanoma cell vaccine consists of melanoma cells that have been induced to express the human leukocyte antigen (HLA) B7.  Vaccination with these altered cells stimulates an anti-tumor immune response via CD8+ cytotoxic T lymphocytes (CTL). (NCI04)
C2746	Berzofsky_Ras_P53_Peptide	Anti-Idiotype_Vaccine	Berzofsky Ras/P53 Peptide Vaccine|Berzofsky Ras/P53 Peptide	A synthetic vaccine combining the peptide antigens of two proteins, ras oncoprotein and tumor suppressor p53. (NCI04)
C2747	Conjugated_Mononclonal_Antibody_CC49	Immunoconjugate	Conjugated Monoclonal Antibody CC49|CONJUGATED MAB CC49 (PA-DOTA-CC49)|PA-DOTA-CC49	A immunoconjugate comprised of a monoclonal antibody directed against the pancarcinoma antigen TAG-72.conjugated to PA-DOTA, a bifunctional chelant.  TAG-72 is a protein/sugar complex found on the surface of many cancer cells, including breast, colon, and pancreatic cancer cells. (NCI04)
C2748	D1_3-Mage-3_Fusion_Protein	Immunoconjugate	D1/3-Mage-3 Fusion Protein|D1/3 MAGE3 HIS|D1/3-MAGE-3-His Fusion Protein|D1/3-Mage-3 Fusion Protein (SB MAGE-3)|D1/3-Mage-3 Fusion Protein (SB MAGE-3)[Prot. D MAGE 3/His]	A recombinant, chimeric protein derived from a melanoma antigenic epitope (MAGE-3) and recognized by specific cytotoxic T lymphocytes.  MAGE-3, a human peptide epitope present in the cytosol of melanoma cells, may be expressed as the fusion protein D1/3-Mage-3; this fusion protein may boost antitumoral immune responses when used in a vaccine formulation. (NCI04)
C2749	EWS-FLI1_Type_1	Antisense_Agent	EWS/FLI 1 Type 1|EF-1|EF-1(EWS/FLI 1 Type 1)|EWS/FLI 1 (type 1)|EWS/FLI 1 Type 1 Fusion Gene	One allele of the transforming chimeric gene resulting from a t(11;22) translocation that is found frequently in patients with Ewing's sarcoma or primitive neuroectodermal tumors (PNET). EWS-FLI 1 type 1 encodes a protein, mTOR, that is a central regulator of translation and cell proliferation. mTOR activates the mitogen-activated protein kinase (MAPK) signaling pathway, resulting in neoplastic transformation. Antisense oligonucleotides that target EWS-FLI 1 type 1 have been used investigationally to treat this genetic anomaly, resulting in cell cycle arrest at G1 phase.  (NCI04)
C2750	EWS-FLI1_Type_2	Antisense_Agent	EWS/FLI 1 Type 2|EF-2|EF-2 (EWS-FLI 1 TYPE 2)|EF-2 (EWS-FLI 1 Type 2)|EWS/FLI 1 (type 2)|EWS/FLI 1 Type 2 Fusion Gene	The more potent transcription activator allele of a transforming chimeric gene resulting from a t(11;22) translocation that is found frequently in Ewing's sarcoma and primitive neuroectodermal tumor (PNET). EWS-FLI1 type 2 encodes the mTOR protein, a central regulator of translation and cell proliferation that activates the mitogen-activated protein kinase (MAPK) signaling system, resulting in neoplastic transformation. Antisense oligonucleotides that target EWS-FLI1 type 2 have been used investigationally to arrest cancer cells in the G1 phase of the cell cycle. (NCI04)
C2751	Elliotts_B_Solution	Drug_Vehicle	Elliotts B Solution|ELLIOTTS B SOLUTION
C2752	EPL_Diluent	Drug_Vehicle	EPL Diluent
C2754	ESO-1_157-165_165v_Peptide	Vaccine_Antigen	ESO-1:157-165(165v) Peptide	A 9-residued peptide vaccine consisting of amino acids 157 through 165 of the cancer/testis (CT) antigen ESO-1. Modified at position 165 (cysteine to valine) to improve immunogenicity, ESO-1:157-165(165v) peptide administered as a vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for ESO-1, resulting in decreased tumor growth. ESO-1 is expressed in a variety of cancers, including melanoma, breast, bladder, prostate, and hepatocellular cancers.  (NCI04)
C2755	Lodenosine	Anti-HIV_Agent	Lodenosine|2'-beta-fluoro-2',3'-dideoxyadenosine|F-DDA (Lodenosine)|F-ddA	A synthetic purine fluoro-dideoxyadenosine derivative, antiviral Lodenosine acts as a reverse transcriptase inhibitor. Although used in clinical trials for treatment of human immunodeficiency (HIV), Lodenosine induces liver or kidney damage and its use has been reconsidered. (NCI04)
C2756	GM-CSF_cDNA-Gold_Complex	Non-Viral_Vector-Gene_Complex	GM-CSF cDNA/Gold Complex|GM-CSF cDNA/gold	Expression vectors containing the complementary DNA (cDNA) of the cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) coated onto gold particles.  A protein cytokine secreted by T-cells and macrophages following cell activation by antigens or mitogens, GM-CSF is indispensable for the growth and development of granulocyte and macrophage progenitor cells. Subsequently, GM-CSF has been shown to activate and stimulate proliferation of mature macrophages and lymphocytes. (NCI04)
C2757	gp100_Adenovirus_Vaccine	Antineoplastic_Vaccine	gp100 Adenovirus Vaccine	A vaccine consisting of a replication-defective recombinant adenovirus that encodes the melanoma antigen glycoprotein 100 (gp100) with potential antineoplastic activity.  Vaccination with gp100 adenovirus vaccine stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the gp100 antigen, resulting in decreased tumor growth. (NCI04)
C2758	gp100_cDNA-Gold_Complex	Non-Viral_Vector-Gene_Complex	gp100 cDNA/Gold Complex|gp100 cDNA/Gold	A synthetic agent derived from the tumor-associated differentiation antigen gp100 DNA.  Gp100 DNA is coated onto microscopic gold beads and used to immunize animals and generate polyclonal antibodies that specifically recognize gp100 antigen.  Gp100 human antigen is a non-mutated self-antigen - glycoprotein -expressed by melanocytes, pigmented retinal cells and most melanoma lesions, but is not expressed in other normal tissues or non-melanoma tumors.  Immunization with human gp100 DNA may induce protective immunity against melanoma and may provide an effective approach for vaccine therapy with tumor-associated antigens against human melanoma. (NCI04)
C2759	gp100_Plasmid_DNA	Non-Viral_Vector-Gene_Complex	Human gp100 Plasmid DNA Vaccine|gp100 Plasmid DNA	A vaccine consisting of a plasmid DNA encoding the human melanoma-associated antigen gp100.  Upon administration, expressed gp100 antigen may stimulate a cytotoxic T cell HLA-A2.1-restricted immune response against tumor cells that express this antigen, resulting in tumor cell lysis. (NCI05)
C2760	gp100_and_GM-CSF_DNA-Gold_Vaccine	DNA_Vaccine	gp100 and GM-CSF DNA/Gold Vaccine|gp100+GM-CSF DNA/Gold	A vaccine consisting of microscopic gold particles coated with plasmid DNA encoding the glycoprotein 100 (gp100) melanoma antigen and granulocyte-macrophage colony-stimulating factor (GM-CSF).  Vaccination with gp100 and GM-CSF DNA/gold vaccine stimulates the host immune system to direct cytotoxic T lymphocytes (CTL) against gp100 positive cells, resulting in decreased tumor growth.  GM-CSF is thought to increase the induction and activation of antigen-presenting cells (APC), allowing for a reduction in the dose of gp100 administered. (NCI04)
C2761	gp100-Fowlpox_Vaccine	Fowlpox_Virus_Vaccine	gp100-Fowlpox Vaccine	A cancer vaccine comprised of a recombinant fowlpox virus vector encoding the melanoma antigen glycoprotein 100 (gp 100) with potential antineoplastic activity.  The expression of gp100 may generate a cellular immune response to melanoma cells; this effect is enhanced by the co-administration of interleukin 2 (IL-2). (NCI04)
C2762	gp100-pulsed_PBL	Peripheral_Blood_Lymphocyte_Vaccine	gp100-Pulsed PBL|GP100-pulsed PBL|gp100-Pulsed Peripheral Blood Mononuclear Cells|gp100-pulsed Peripheral Blood Lymphocytes	Peripheral blood lymphocytes (PBL) harvested from host blood and stimulated in vitro with tumor-specific gp 100 antigen. 'Pulsing' PBL with gp100, a tumor associated antigen (TAA) commonly expressed by melanoma cells, may increase melanoma-reactive cytotoxic lymphocytes (CTL) in the PBL cell population. Autologous gp100-pulsed PBL have been administered to melanoma patients in order to augment cytotoxic immune responses to melanoma.  (NCI04)
C2763	gp100_ES209-217_210M	Vaccine_Antigen	gp100: ES209-217 (210M)|G9 209-2M|gp100:209-217(210M)|gp100:209-217(210M)[aka G9 209-2M]	A synthetic peptide vaccine consisting of amino acids 209 through 217 of the glycoprotein 100 (gp100) melanoma antigen that has been modified at the anchor residue to increase binding affinity.  Vaccination with gp100_ ES209-217 (210M) may stimulate the host immune system to mount a cytotoxic T lymphocyte and T-helper response against tumor cells positive for gp100, resulting in decreased tumor growth. (NCI04)
C2764	gp100_154-162_Peptide	Vaccine_Antigen	gp100:154-162 Peptide	A peptide consisting of amino acid residues 154 through 162 of the melanoma-melanocyte antigen gp100. Vaccination with gp100:154-162 peptide may enhance tumor-specific T-cell immunity. gp100 antigen is a self-antigen expressed by melanocytes, pigmented retinal cells and most melanoma lesions and recognized via class I and II HLA-restricted mechanisms. (NCI04)
C2765	gp100_17-25	Vaccine_Antigen	gp100:17-25	A synthetic peptide vaccine consisting of amino acids 17 through 25 of the glycoprotein 100 (gp100) melanoma antigen.  Vaccination with gp100_17-25 may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for gp100, resulting in decreased tumor growth. (NCI04)
C2766	gp100_209-217	Vaccine_Antigen	gp100:209-217|G9-209|gp100:209-217 [aka G9-209]	A synthetic peptide vaccine consisting of the amino acids 209 through 217 of the glycoprotein 100 (gp100) melanoma antigen.  Vaccination with gp100_209-217 may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for gp100, resulting in decreased tumor growth. (NCI04)
C2767	gp100_280-288_Peptide	Melanoma_Vaccine	gp100:280-288 Peptide Vaccine|GP100 Peptide Melanoma Vaccine YLEPGPVTA|gp100:280-288 Peptide|gp100:280-288(288V) Peptide	A vaccine consisting of the amino acids 280 through 288 of the melanoma antigen glycoprotein 100 (gp100) with potential antineoplastic activity.  Vaccination with gp100:280-288 peptide stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the gp100 antigen, resulting in decreased tumor growth. (NCI04)
C2768	gp100_44-59	Vaccine_Antigen	gp100:44-59	A synthetic peptide vaccine consisting of the amino acids 44 through 59 of the glycoprotein 100 (gp100) melanoma antigen.  Vaccination with gp100_44-59 may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for gp100, resulting in decreased tumor growth. (NCI04)
C2769	HPV-16E7_86-93	Retired_Concepts	HPV-16E7 (86-93)
C2771	KLH-Lymphoma_Ig_Vaccine	Anti-Idiotype_Vaccine	KLH-Lymphoma Ig Vaccine|Id KLH Lymphoma|Lymphoma Ig Vaccine-KLH	An chimeric lymphoma vaccine generated by combining the recipient's Ig idiotype (Id) protein with keyhole limpet hemocyanin (KLH), an immune stimulant, with potential antineoplastic activity.  Vaccination with KLH-Lymphoma Ig Vaccine stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against lymphoma cells, resulting in decreased tumor growth. (NCI04)
C2772	MART-1_26-35_27L	Vaccine_Antigen	MART-1:26-35 (27L)|MART - 1:26-35 (27L)	A synthetic peptide vaccine consisting of amino acids 26 through 35 of the melanoma differentiation antigen MART-1 with a modification at position 27 (alanine to leucine) to improve immunogenicity.  Vaccination with MART-1_26-35 (27L) stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for MART-1, resulting in decreased tumor growth. (NCI04)
C2773	MART-1_Adenovirus_Vaccine	Antineoplastic_Vaccine	MART-1 Adenovirus Vaccine	A vaccine consisting of recombinant adenovirus vector encoding MART-1 (melanoma antigen recognized by T-cells 1), an immunogenic protein of unknown function that is expressed by certain types of melanoma.  Vaccination with MART-1 adenovirus vaccine may stimulate the host immune system to direct cytotoxic T lymphocytes (CTL) against MART-1 positive melanoma cells, resulting in an antitumor effect. (NCI04)
C2774	MART-1_Vaccinia_Vaccine	Vaccinia_Vaccine	MART-1 Vaccinia Vaccine	A cancer vaccine consisting of an attenuated recombinant vaccinia virus expressing the melanoma-associated antigen MART-1. Vaccination with this agent may stimulate cytotoxic host immune responses to melanoma cells. (NCI04)
C2775	MART-1_27-35_PEPTIDE	Vaccine_Antigen	MART-1:27-35 Peptide|27-35(27L):MART-1	A natural or synthetic peptide consisting of amino acid residues 27 through 35 of the melanoma-associated antigen MART-1 with potential use in cancer immunotherapy. Vaccination with this peptide may induce cytotoxic host immune responses to melanoma cells. (NCI04)
C2776	MART-1_Fowlpox_Vaccine	Fowlpox_Virus_Vaccine	MART-1 Fowlpox Vaccine	A synthetic cancer vaccine derived from a melanoma-associated antigen, MART-1.  Antigenic peptides derived from MART-1 are recognized by CD8+ T lymphocytes and have been used to immunize patients with advanced melanomas; prolonged immunization may result in a reduction in tumor size.  Fowlpox virus is an attractive vector because its genome is easy to manipulate and it does not multiply in human tissues. (NCI04)
C2777	Monoclonal_Antibody_95-5-49	Monoclonal_Antibody	Monoclonal Antibody 95-5-49|MOAB 3-275 (Moab 95-5-49)|Monoclonal Antibody 3-275	A recombinant monoclonal antibody directed against the lymphocyte receptor CD2 with potential use in cancer immunotherapy.  Activation of the CD2 molecule, one of several lymphocyte receptors, rapidly initiates signaling events regulating integrin-mediated cell adhesion. (NCI04)
C2778	Monoclonal_Antibody_95-6-22	Monoclonal_Antibody	Monoclonal Antibody 95-6-22|MOAB 3-276 (Moab 95-6-22)|Monoclonal Antibody 3-276	A recombinant monoclonal antibody directed against human T-cells designed to generate cytotoxic T lymphocyte (CTL) responses to tumor antigens with potential use in cancer immunotherapy. (NCI04)
C2779	_1B4M-DTPA-conjugated_muB3	Immunoconjugate	1B4M-DTPA-conjugated muB3|MOAB B-3-1B4M-DTPA	A conjugate of a murine immunoglobulin antibody directed against the Lewis carbohydrate epitope (B3 antigen) and a isothiocyanatobenzyl derivative (1B4M) of diethylenetriaminepentaacetic acid (DTPA) with potential use in cancer immunotherapy.  The Lewis carbohydrate epitope is present on a variety of proteins located on the surface of many different types of tumor cells and a limited number of normal tissues. (NCI04)
C2780	Monoclonal_Antibody_HCC49DCH2	Monoclonal_Antibody	Monoclonal Antibody HCC49DCH2|MOAB HCC49DCH2	A humanized CH2 domain-deleted second-generation monoclonal antibody based on the antibody B72.3 that is directed against tumor-associated glycoprotein 72 (TAG72).  TAG72 is expressed by gastric, breast, pancreatic, colorectal, and ovarian carcinoma cells. (NCI04)
C2781	MOv-PBL	Peripheral_Blood_Lymphocyte_Vaccine	MOv-PBL Vaccine|MFG-S-Mov18|MOV-PBL (MFG-S-MOv18)|Ovarian Cancer-Associated Antigen-Pulsed PBL	Peripheral blood lymphocytes (PBL) transfected to express MOv have been designed for possible use in autologous adoptive cellular immunotherapy of ovarian adenocarcinomas that overexpress folate-binding protein. MOv-PBLs express MOv-gamma (MOv), a chimeric receptor gene product derived from a recombinant gene encoding the variable region of murine monoclonal antibody MOv18 against folate-binding protein (FBP), often overexpressed in human ovarian cancer cells, and the human gene encoding the IgG and IgE Fc receptor gamma subunit. Autologous vaccination with these PBLs stimulates a host cytotoxic T lymphocyte response against ovarian cancer cells that overexpress FBP. (NCI04)
C2782	Myeloma_Ig_Id-KLH_Conjugate_Vaccine	Anti-Idiotype_Vaccine	Myeloma Ig Id-KLH Conjugate Vaccine|Id KLH Myeloma|Idiotype KLH Myeloma Vaccine|Myeloma Ig Id Vaccine-KLH	A vaccine consisting of myeloma-specific immunoglobulin conjugated to keyhole limpet hemocyanin (KLH), an immune stimulant, with potential antineoplastic activity.  Vaccination with myeloma Ig Id-KLH conjugate vaccine stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against myeloma cells, resulting in decreased tumor growth. (NCI04)
C2783	Oncovax-ID_IL-2_Vaccine	Antineoplastic_Vaccine	Oncovax-ID/IL-2 Vaccine|Liposomal Lymphoma Idiotype Ig plus Interleukin-2|T96-0057/Liposomal Lymphoma IgId	A cancer vaccine consisting of a mixture of a murine lymphoma-derived idiotype and interleukin-2 (IL-2) encapsulated in dimyristoylphosphatidylcholine liposomes.  The use of a liposomal carrier confers immunogenicity to the naturally non-immunogenic idiotype. (NCI04)
C2784	P53_264-272_Peptide_MPS-128	Vaccine_Antigen	p53:264-272 Peptide|MPS-128	A synthetic peptide derived from the tumor suppressor protein p53 with potential use in cancer immunotherapy.  p53:264-272 peptide consists of amino acid residues 264 through 272 of the p53 protein. Vaccination with this agent may induce a cytotoxic host immune response to tumor cells. (NCI04)
C2785	Paclitaxel_PPE_Microspheres	Paclitaxel	Paclitaxel PPE Microspheres|Paclimer Microspheres|Paclimer Microspheres (Polilactofate/Paclitaxel)|Paclitaxel Biopolymer Formulation
C2786	PCLUS_3-18MN	HIV_Vaccine	PCLUS 3-18MN|AIDs Peptide Vaccine (Peninsula) Construct 3-18 MN	A synthetic HIV-1 envelope peptide that was developed for use as a vaccine.  Vaccination with PCLUS 3-18MN stimulates the host immune system to mount cytotoxic T lymphocyte (CTL) and T helper cell responses, and induce the production of neutralizing antibodies. (NCI04)
C2787	PCLUS_6_1-18MN	HIV_Vaccine	PCLUS 6.1-18MN|AIDs Peptide Vaccine (Peninsula) Construct 6.1-18 MN	A synthetic HIV-1 envelope peptide that was developed for use as a vaccine.  Vaccination with PCLUS 6.1-18MN stimulates the host immune system to mount cytotoxic T lymphocyte (CTL) and T helper cell responses, and induce the production of neutralizing antibodies. (NCI04)
C2788	Peg_400_Diluent	Polyethylene_Glycol	Peg 400 Diluent
C2789	PEG_Diluent	Polyethylene_Glycol	PEG Diluent
C2790	PG13-LNc8_Retroviral_Transduced_Cloned_T-Cells	Biological_Agent	PG13/LNc8 Retroviral Transduced Cloned T-Cells	A preparation of T lymphocytes harvested from a patient with cancer and transduced with the PG13/Lnc8 retroviral vector, a clone of the LN vector that encodes the neomycin phosphotransferase gene.  The modified T lymphocytes are cloned using an ex vivo technique and infused back into the patient, where they may elicit a host immune response against tumor cells.  The neomycin phosphotransferase gene product has no direct therapeutic value; it serves as a molecular marker to monitor the presence and localization of the PG13/Lnc8-transduced T-lymphocytes in the host. (NCI04)
C2791	pNGVL3-hIL12	Viral_Vector-Gene_Complex	pNGVL3-hIL12|pNGVL3-hIL12 (IL-12 DNA)	A plasmid vector encoding interleukin-12 (IL-12) with potential use in the gene therapy of cancer.  pNGVL3-hIL12 may induce a high level of IL-12 protein expression during transient transfection of host cells.  IL-12 is a proinflammatory cytokine with numerous immunoregulatory functions and may augment host immune responses to tumor cells. (NCI04)
C2792	PR18_ras-13_Cys_Peptide	Mutated_Ras_Peptide	PR18 (ras-13 Cys) Peptide	A truncated synthetic form of the oncogene Ras, whose protein product p21 is located in the plasma membrane and transduces growth and differentiation signals from activated receptors to protein kinases within the cell.  Because mutated Ras proteins may represent highly specific epitopes for T-cell recognition, PR18 (ras-13 Cys) peptide may be used in the vaccine immunotherapy of cancer. (NCI04)
C2793	PR54_ras-13_Asp_Peptide	Mutated_Ras_Peptide	PR54 (ras-13 Asp) Peptide|Ras Peptide PR54 (KLVVVGAGDVGKSALTI)	A synthetic form of the ras peptide containing a point mutation at position 13 (glycine to asparagine). Vaccines using mutant ras peptides may be used in the immunotherapy of various cancers that express ras mutations. (NCI04)
C2794	PR5V10_ras-12_Val_Peptide	Mutated_Ras_Peptide	PR5V10 (ras-12 Val) Peptide|Ras Peptide PR5V10 (KLVVVGAVGV)	A synthetic form of the ras peptide containing a point mutation at position 12 (glycine to valine). Vaccines using mutant ras peptides may be used in the immunotherapy of various cancers that express ras mutations. (NCI04)
C2795	PR6V10_ras-12_Asp_Peptide	Mutated_Ras_Peptide	PR6V10 (ras-12 Asp) Peptide	A truncated synthetic form of the oncogene Ras, whose protein product p21 is located in the plasma membrane and transduces growth and differentiation signals from activated receptors to protein kinases within the cell.  Because mutated Ras proteins may represent highly specific epitopes for T-cell recognition, PR6V10 (ras-12 Asp) peptide may be used in the vaccine immunotherapy of cancer. (NCI04)
C2796	PR7v10_ras_12Ala_Peptide	Mutated_Ras_Peptide	PR7V10 (ras-12 Ala) Peptide|PR7v10 (ras 12Ala) Peptide	A natural or synthetic peptide derived from the Ras protein with potential use in cancer immunotherapy. Ras protein regulates a number of signalling molecules by translocating them to the plasma membrane for activation and may serve as a branchpoint in signal transduction because it orchestrates the activity of multiple signalling pathways to regulate diverse cellular functions. Ras-12 Ala is a mutated form of the wild-type Ras protein in which the amino acid glycine at codon 12 is replaced with alanine. Vaccination with mutated Ras proteins or peptides may stimulate cytotoxic host immune responses to tumor cells that express similarly mutated Ras proteins. (NCI04)
C2797	Proteinase3_PR1_Peptide	Vaccine_Antigen	Proteinase 3:PR1 Peptide|Proteinase3:PR1 Peptide	A synthetic HLA-A2-restricted nonapeptide derived from proteinase 3 with potential use in cancer immunotherapy. Cytotoxic T lymphocytes (CTL) primed with proteinase 3 PR1 peptide attack leukemic cells that express proteinase 3 aberrantly. Proteinase 3 is a serine proteinase that activates progelatinase A and is involved in metastasis and angiogenesis. (NCI04)
C2798	PSA-3_Peptide	Vaccine_Antigen	PSA-3 Peptide|PSA-3	A natural or synthetic peptide consisting of nine amino acids derived from the prostate-specific self-antigen (PSA).  PSA-3 peptide may exhibit greater immunostimulant activity than PSA. (NCI04)
C2799	PV701	Oncolytic_Virus	PV701	An attenuated, replication-competent, oncolytic strain of Newcastle disease virus. PV701 selectively lyses tumor cells. The selectivity of this agent is related to defects in the interferon-mediated antiviral response found in tumor cells. (NCI04)
C2800	PAX3_FKHR	Antisense_Agent	PAX3/FKHR|PAX3/FKHR Fusion Gene|PXFK|PXFK (PAX3/FKHR)	An antisense oligonucleotide targeting mRNA of the chimeric PAX3/FKHR fusion gene, an oncogenic transcriptional activator found in rhabdomyosarcomas.  PAX3/FKHR antisense oligonucleotide down-regulates protein production and induces apoptosis in cells expressing the PAX3/FKHR fusion gene. (NCI04)
C2801	Pyroxamide	Histone_Deacetylase_Inhibitor	Pyroxamide|Suberoyl-3-aminopyridineamide Hydroxamic Acid|pyroxamide	A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called histone deacetylase inhibitors.
C2802	Ras_Peptide_ASP	Mutated_Ras_Peptide	Ras Peptide ASP	A synthetic form of the ras peptide containing a point mutation at position 12 (glycine to aspartic acid) with potential antineoplastic activity.  Vaccination with ras peptide Asp may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for this ras mutation, resulting in decreased tumor growth. (NCI04)
C2803	Ras_Peptide_CYS	Mutated_Ras_Peptide	Ras Peptide CYS|Ras (sub 5-17) Peptide (C12)	A synthetic form of the ras peptide containing a point mutation at position 12 (glycine to cysteine) with potential antineoplastic activity.  Vaccination with ras peptide Cys stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for this ras mutation, resulting in decreased tumor growth. (NCI04)
C2804	Ras_Peptide_VAL	Mutated_Ras_Peptide	Ras Peptide VAL	A synthetic form of the ras peptide containing a point mutation at position 12 (glycine to valine) with potential antineoplastic activity.  Vaccination with ras peptide Val stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for this ras mutation, resulting in decreased tumor growth. (NCI04)
C2805	Recombinant_Fowlpox-Mgp100_Vaccine	Fowlpox_Virus_Vaccine	Recombinant Fowlpox-Mgp100 Vaccine|rF Mgp 100 Vaccine|rV Mgp100 Vaccine|rV-Mgp100 Vaccine	A vaccine consisting of a replication-defective recombinant fowlpox virus that encodes for the murine melanoma antigen glycoprotein 100 (mgp100) with potential antineoplastic activity.  Vaccination with recombinant fowlpox-mgp100 vaccine stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the gp100 antigen, resulting in decreased tumor growth. (NCI04)
C2806	Recombinant_Fowlpox-gp100p209	Viral_Vector-Gene_Complex	Recombinant Fowlpox-gp100p209|rF-gp100P209|rF-gp100p209
C2807	Fowlpox-Tyrosinase_Vaccine	Fowlpox_Virus_Vaccine	Fowlpox-Tyrosinase Vaccine|Fowlpox-Tyrosinase|rF-TYR Vaccine|rF-TYR vaccine (Tyrosinase-Fowl Pox)	A recombinant fowlpox virus vaccine with potential antineoplastic activity.  Binding to the melanoma antigen tyrosinase, the fowlpox-tyrosinase vaccine generates cellular immune responses against melanoma cells expressing the tyrosinase antigen; this effect is enhanced by the co-administration of interleukin 2 (IL-2). Fowlpox adenovirus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells. (NCI04)
C2808	Recombinant_Human_IL-4	Therapeutic_Interleukin-4	Recombinant Human IL-4|RHIL-4	A recombinant agent which is chemically identical to or similar to the endogenous cytokine interleukin 4 (IL-4) with potential antineoplastic activity.  Recombinant IL-4 may induce cytotoxic T lymphocyte (CTL) activity, thereby increasing the cytotoxic host immune response against tumor cells. (NCI04)
C2809	Recombinant_Vaccinia-CEA	Viral_Vector-Gene_Complex	Recombinant Vaccinia-CEA|RV CEA|rV-CEA	A recombinant vaccinia virus encoding carcinoembryonic antigen (CEA). CEA is overexpressed in several cancer cell types, including gastrointestinal, breast, and non-small cell lung cancers. Attenuated vaccinia virus is a highly effective immunizing agent that evokes both humoral and cell-mediated responses.  Vaccination with this agent may evoke a cytotoxic immune response to CEA-expressing cells. (NCI04)
C2810	SB-AS02B_Adjuvant	Vaccine_Adjuvant	SB-AS02B Adjuvant	A proprietary oil-in-water emulsion specifically designed for combining protein preparations used in vaccines.  SB-AS02B adjuvant contains monophosphoryl lipid A and QS21, a saponin extracted from the South American tree Quillaja Saponaria Molina. This agent may be used for formulating cancer-specific vaccine preparations such as those containing MAGE-3 melanoma protein. (NCI04)
C2811	HspE7	Vaccine_Antigen	HspE7|HPV 16 E7/HSP65 Vaccine|HPV E7 Peptide Epitope Vaccine|HspE7 Therapeutic Vaccine|SGN-00101|SGN-00101 (HspE7)	A recombinant chimeric protein composed of the heat shock protein 65 (Hsp65) from Mycobacterium bovis, and the human papilloma viral (HPV) protein E7.  Hsp65, similar to other members of its family of proteins, elicits a strong immune response and may be used to design vaccines against a number of different cancers.  E7 protein is involved in carcinogenesis of anal and cervical tumors, and represents a tumor antigen that may be specifically targeted by lymphocytes. (NCI04)
C2812	Sterile_0_01N_Hydrochloride	Drug_Vehicle	Sterile 0.01N Hydrochloride|Sterile 0.01N HCl
C2813	Telomerase_540-548_Peptide	Retired_Concepts	Telomerase:540-548 Peptide
C2814	Tetanus_Toxoid_Aluminum_Phosphate_Adsorbed_Vaccine	Vaccine	Tetanus Toxoid Aluminum Phosphate Adsorbed Vaccine	A vaccine that contains detoxified tetanus toxin of Clostridium tetani. Aluminum phosphate is an adjunct that adsorbs the tetanus antigens to increase the half-life and immunogenicity of the vaccine.
C2815	TRP-2_180-188_Peptide	Vaccine_Antigen	TRP-2: 180-188 Peptide	A recombinant peptide consisting of amino acid residues 180 to 188 of the tyrosinase-related protein 2 (TRP2).  Expressed by cells of melanocyte origin, TRP2 is an enzyme involved in the process that converts tyrosinase to melanin pigments. Vaccination with TRP-2: 180-188 peptide may induce cytotoxic T lymphocyte (CTL) responses to melanoma cells. (NCI04)
C2816	TRP1_0RF3_1-9	Vaccine_Antigen	TRP1(0RF3):1-9	A recombinant peptide consisting of amino acid residues 1 to 9 of the tyrosinase-related protein 1 (TRP1).  Expressed by cells of melanoctye origin, TRP1 is an enzyme involved in the process that converts tyrosinase to melanin pigments. Vaccination with TRP1(0RF3):1-9 may stimulate cytotoxic T cell responses to melanoma cells.. (NCI04)
C2817	Tumor_Cell_Vaccine_plus_BCG	Tumor_Cell_Derivative_Vaccine	Tumor Cell Vaccine plus BCG	A mixture of allogeneic or autologous tumor cells and bacillus Calmette-Guerin (BCG) in a liquid vehicle with potential antineoplastic activity.  Vaccination of the host with tumor cell vaccine plus BCG may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against similar host tumor cells, resulting in decreased tumor growth. The BCG component serves as an adjuvant, a nonspecific stimulator of the immune response. (NCI04)
C2818	TYROSINASE_206-214	Tyrosinase_Peptide	Tyrosinase:206-214	A synthetic peptide vaccine consisting of amino acids 206 through 214 of the melanoma-associated antigen tyrosinase.  Vaccination with TYROSINASE_206-214 may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for tyrosinase, resulting in decreased tumor growth. (NCI04)
C2819	Tyrosinase_240-251_244S	Tyrosinase_Peptide	Tyrosinase:240-251(244S)	A recombinant peptide consisting of amino acid residues 240 to 251 of the enzyme tyrosinase, a protein frequently expressed by melanoma cells.  Vaccination with this agent may stimulate cytotoxic T lymphocytes and class II MHC-restricted melanoma-reactive CD4+ T cells to target tyrosinase-expressing tumor cells. (NCI04)
C2820	TYROSINASE_368-376_370D	Tyrosinase_Peptide	Tyrosinase:368-376(370D)	A synthetic peptide consisting of amino acids 368 through 376 of the melanoma-associated antigen tyrosinase with a modification at position 370 to increase binding affinity.  Vaccination with TYROSINASE:368-376(370D) may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for tyrosinase, thereby decreasing tumor growth. (NCI04)
C2821	Unconjugated_Lymphoma_Ig_Id	Anti-Idiotype_Vaccine	Unconjugated Lymphoma Ig Id|Unconjugated Lymphoma Immunoglobulin Idiotype	A vaccine consisting of lymphoma-specific immunoglobulin that is not conjugated to a carrier molecule.  Vaccination with unconjugated lymphoma Ig Id stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against lymphoma cells, resulting in decreased tumor growth. (NCI04)
C2822	Unconjugated_Myeloma_Ig_Id	Anti-Idiotype_Vaccine	Unconjugated Myeloma Ig Id|Unconjugated Myeloma Immunoglobulin Idiotype|Unconjugated Myleoma Immunoglobulin IG ID Vaccine	A vaccine consisting of myeloma-specific immunoglobulin that is not conjugated to a carrier molecule.  Vaccination with unconjugated myeloma Ig Id stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against myeloma cells, resulting in decreased tumor growth. (NCI04)
C2823	VHL_Peptides	Retired_Concepts	VHL Peptides
C2824	VHL2_Y12M	Von_Hippel-Lindau_Peptide_Vaccine	VHL2 (Y12M)	A peptide vaccine derived from the von Hippel-Lindau (VHL) tumor suppressor protein, a general transcription factor.  VHL2 (Y12M) peptide is a point mutation variant (from tyrosine to methionine) of the VHL protein.  It might be used to elicit or boost cellular immunity to cancers that expressing the von Hippel-Lindau mutation. (NCI04)
C2825	XK469R	Topoisomerase-II_Inhibitor	XK469R|R(+) XK469|Racemic XK469|XK469 Racemic	The racemic form of a synthetic quinoxaline phenoxypropionic acid derivative with antineoplastic properties. XK469R selectively inhibits topoisomerase II by stabilizing the enzyme-DNA intermediates in which topoisomerase subunits are covalently linked to DNA through 5-phosphotyrosyl linkages, thereby interfering with DNA repair and replication, RNA and protein synthesis. This agent possesses unusual solid tumor selectivity and activity against multidrug-resistant cancer cells. XK469R is more water soluble and active than the pure isomers, R(+)XK469 and S(-)XK469. (NCI05)
C2826	Telomerase_Inhibitor	Enzyme_Inhibitor	Telomerase Inhibitor	An agent that inhibits the telomerase, a ribonucleoprotein enzyme that adds telomeric sequences to the 3-ends of eukaryotic chromosomes, thus permitting proliferation of immortal cells beyond the limits of cellular senescence.  Telomerase is active in most tumors cells, but is quiescent in adjacent normal cells. (NCI04)
C2827	Verapamil_Hydrochloride	Verapamil	Verapamil Hydrochloride|(+-)-Verapamil hydrochloride|Calan|VERAPAMIL HYDROCHLORIDE|Verapamil hydrochloride	The hydrochloride form of Verapamil, which is a phenylalkylamine calcium channel blocking agent. Verapamil inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility.  This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
C2828	Topotecan_Hydrochloride	Topotecan	Topotecan Hydrochloride|(S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4'; 6,7] indolizino[1,2-b] quinoline-3,14-(4H,12H)-dione monohydrochloride|Hycamtin|TOPOTECAN HYDROCHLORIDE|Topotecan HCL|Topotecan hydrochloride	A hydrochloride salt of the semisynthetic camptothecin analog topotecan with antineoplastic activity.  During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. (NCI04)
C2829	Fluoxetine_Hydrochloride	Fluoxetine	Fluoxetine Hydrochloride|FLUOXETINE HYDROCHLORIDE|Fluoxetine HCl|Fluoxetine HCl (Prozac)|Prozac
C2830	ONYX-015	Oncolytic_Virus	ONYX-015|CI-1042|E1B 55kDa mutant adenovirus dl1520|E1B-Attenuated Adenovirus|ONYX-015 (E1B-Attenuated Adenovirus)	A modified cold virus that selectively grows in and destroys certain types of cancer cells and leaves normal cells undamaged.
C2831	Glucose	Carbohydrate	Glucose|GLU|glucose	A simple sugar monosaccharide having two isoforms, alpha and beta, with a chemical structure of C6H12O6 that acts as an energy source for both plants and animals by reacting with oxygen to form Carbon Dioxide and Water, releasing energy.(NCI)
C2832	d-alpha-Tocopherol	Vitamin_E	d-Alpha-Tocopherol|.alpha. Tocopherol|Alpha-Tocopherol|Tocopherol-Alpha|Tocopherol-D-Alpha|d-alpha-Tocopherol	A naturally-occurring form of vitamin E, a fat-soluble vitamin with potent antioxidant properties.  Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acids), d-alpha-Tocopherol is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production.  Vitamin E also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. (NCI04)
C2833	L-Selenomethionine	Selenomethionine	L-Selenomethionine|(S)-2-Amino-4-(methylseleno)butanoic Acid|L-selenomethionine (Selenium)|SeMet|Seleno-l-methionine|Selenomethionine-L	The amino acid methionine with selenium substituting for the sulphur moiety.  Methionine is an essential amino acid in humans, whereas selenium is a free-radical scavenging anti-oxidant, essential for the protection of various tissues from the damages of lipid peroxidation.  As a trace mineral that is toxic in high doses, selenium is a cofactor for glutathione peroxidase, an anti-oxidant enzyme that neutralizes hydrogen peroxide.  L-Selenomethionine is considered a safe, efficacious form of selenium and is readily bioavailable.  Selenium may be chemoprotective for certain cancers, particularly prostate cancer. (NCI04)
C2834	Vitamin_E_Acetate	Vitamin_E	Vitamin E Acetate|(+)-alpha-Tocopherol Acetate|(+/-)-alpha-Tocopherol Acetate|3,4-Dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-ol Acetate|TOCOPHEROLACETATE-D-ALPHA|Tocopherol acetate|[2R-[2*(4R*,8R*)]]-3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-Benzopyran-6-ol acetate|d,l-alpha-Tocopherol Acetate|d-alpha-Tocopherol acetate|dl-.alpha.-Tocopheryl acetate|dl-Alpha-Tocopheryl Acetate	The acetate ester of a fat-soluble vitamin with potent antioxidant properties.  Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acid), vitamin E is a generic name for a group of compounds known as tocopherols and tocotrienols (tocols).  This agent is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production.  Vitamin E also inhibits angiogenesis and tumor dormancy through suppressing vascular endothelial growth factor (VEGF) gene transcription. (NCI04)
C2835	Vaccine_Antigen	Antigen	Vaccine Antigen	A vaccine component consisting of a protein, small peptide, or polysaccharide, natural or synthetic, that once administered is bound by antibody, thereby inducing mechanisms of antibody-dependent cell-mediated cytotoxicity (ADCC).  In cancer immunotherapy, a cancer vaccine containing specific tumor-associated antigens (TAAs) may be used to boost an immune response against a tumor expressing those TAAs. (NCI04)
C2836	Sodium_Chloride_0_9	Saline	Sodium Chloride 0.9%|Normal Saline
C2837	Recombinant_Fowlpox-Prostate_Specific_Antigen	Viral_Vector-Gene_Complex	Recombinant Fowlpox-Prostate Specific Antigen|Recombinant Fowlpox-PSA|rF-PSA	A recombinant cancer vaccine consisting of a fowlpox virus vector encoding the prostate-specific antigen (PSA). This agent stimulates cytotoxic T-lymphocytes to target PSA-expressing tumor cells. The fowlpox virus vector is easily manipulated and does not multiply in human tissues. (NCI04)
C2838	Recombinant_Fowlpox-B7_1	Viral_Vector-Gene_Complex	Recombinant Fowlpox-B7.1|RF-B7.1|rF-B7.1	A recombinant fowlpox virus vector encoding human B7.1 (CD80 antigen), a T-cell costimulatory molecule.  Recombinant Fowlpox-B7.1 may be used as a vaccine vector; incorporating the B7-1 gene into this vector may enhance the presentation of fowlpox virus vector-encoded tumor antigens to antigen presenting cells (APC) and activate cytotoxic T-cells against tumor antigen-expressing tumors. The fowlpox vector is easily manipulated and does not multiply in human tissues. (NCI04)
C2839	Fowlpox_Vaccine	Retired_Concepts	Fowlpox Vaccine|Fowlpox Virus Vaccine	A recombinant virus-based vaccine that contains various peptide antigens.  Fowlpox virus is an attractive vector because its genome is easy to manipulate and it does not multiply in human tissues.  Strong CD8 T cell responses may be induced after prolonged immunization and have been associated with tumor regression. (NCI04)
C2840	Recombinant_Vaccinia-B7_1	Retired_Concepts	Recombinant Vaccinia-B7.1|RV-B7 (Recomb Vaccinia/B7)|rV-B7 (Recomb Vaccinia/B7)|rV-B7.1	A recombinant vaccinia virus encoding the T-cell co-stimulatory molecule B7-1. Co-administration of recombinant vaccinia-B7.1 and a tumor-associated antigen in a cancer vaccine enhances tumor-associated antigen-specific T-cell responses. (NCI04)
C2841	Peripheral_Blood_Lymphocyte_Vaccine	Antineoplastic_Vaccine	Peripheral Blood Lymphocyte Vaccine	A class of vaccines with potential antineoplastic activity.  Peripheral blood lymphocytes (PBL) are first harvested from a cancer patient and induced to express a particular tumor-associated antigen or multiple antigens.  Autologous vaccination with activated PBL stimulates the host immune system to produce antibodies and/or mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for the antigen(s), resulting in decreased tumor growth. (NCI04)
C2842	DNA_Binding_Agent	Antineoplastic_Agent	DNA Binding Agent	DNA binding molecules regulate mechanisms central to cellular function, including DNA replication and gene expression. Many small molecules that mimic or block these processes offer potential therapeutic agents. Understanding how complexation affects both the structural and mechanical properties of DNA is an important step towards understanding the functional mechanisms of binding agents, and may also provide a key to more rational drug design. There are three major classes of binding modes: intercalation, groove binding and covalent crosslinking.
C2843	Camptothecin_Analogue	Topoisomerase-I_Inhibitor	Camptothecin Analogue|camptothecin analogue	An anticancer drug related in structure to camptothecin, a topoisomerase inhibitor. One such drug is aminocamptothecin.
C2844	Actinomycin_F1	Actinomycin_Antibiotic	Actinomycin F1	A chromopeptide antineoplastic antibiotic isolated from the bacterium Streptomyces chrysomallus.  Actinomycin F1 intercalates into the minor groove of DNA and binds to topoisomerase II, leading to the inhibition of DNA replication and RNA and protein synthesis. (NCI04)
C2845	Linker_DNA	Deoxyribonucleic_Acid	Linker DNA|Nucleosomal Linker	The DNA found between nucleosomes on chromatin; since it is not complexed to proteins as strongly as other forms of DNA, it is accessible to exonuclease hydrolysis.
C2846	Glucosidase_Inhibitor	Enzyme_Inhibitor	Glucosidase Inhibitor	A class of agents that reversibly inhibit the membrane-bound intestinal glucosidases (usually alpha glucosidases), enzymes that hydrolyze complex sugars into glucose in the intestines, thereby delaying the metabolism of dietary carbohydrates and reducing postprandial plasma glucose.  A glucosidase inhibitor is often structurally similar to glucose. (NCI04)
C2847	Mesothorium	Radioisotope	Mesothorium	There are two mesothoriums produced in thorium decay. Mesothorium I is an isotope of radium; mesothorium II is an isotope of actinium.
C2848	Polyvalent_Vaccine	Vaccine	Polyvalent Vaccine	A vaccine which will result in protection to several, closely related, agents.
C2849	Congenital_Abnormality	Congenital_or_Acquired_Anatomic_Abnormality	Congenital Abnormality|Birth Defect|Congenital Anatomic Abnormality|Congenital Anatomical Abnormality|Congenital Deformity|Congenital Malformation	Any abnormality, anatomical or biochemical, evident at birth or during the neonatal period.
C2850	Achlorhydria	Non-Neoplastic_Gastrointestinal_Disorder|Stomach_Disorder	Achlorhydria|achlorhydria	(a-klor-HY-dree-a) A lack of hydrochloric acid in the digestive juices in the stomach. Hydrochloric acid helps digest food.
C2851	AIDS	T-Cell_Immunodeficiency	Acquired Immunodeficiency Syndrome|AIDS|Acquired Immune Deficiency|acquired immunodeficiency syndrome	A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV).  It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes.  Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea.  Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin's lymphoma and Kaposi's sarcoma).  The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood. -- 2004
C2852	Adenocarcinoma	Carcinoma|Glandular_Cell_Neoplasm	Adenocarcinoma|adenocarcinoma	(AD-in-o-kar-sin-O-ma) Cancer that begins in cells that line certain internal organs and that have glandular (secretory) properties.
C2853	Papillary_Adenocarcinoma	Adenocarcinoma|Papillary_Carcinoma	Papillary Adenocarcinoma
C2854	Warthin_s_Tumor	Adenoma|Benign_Salivary_Gland_Neoplasm	Warthin's Tumor|Adenolymphoma|Papillary Cystadenoma Lymphomatosum	An adenoma characterized by an oncocytic, often papillary, epithelial component, dense lymphoid stroma, and cystic spaces. It occurs primarily in the parotid gland, and is the second most common benign parotid salivary gland tumor. A strong association with smoking has been reported. About 10% develop simultaneous or metachronous contralateral tumors.  It typically presents as a painless swelling in the lower portion of the parotid gland. --2003
C2855	Adenoma	Glandular_Cell_Neoplasm	Adenoma|adenoma	(ad-in-O-ma) A noncancerous tumor.
C2856	Basophilic_Adenoma	Pituitary_Gland_Neoplasm_Antiquated	Pituitary Gland Basophil Adenoma|Basophilic Adenoma|Basophilic Pituitary Gland Adenoma|Mucoid Cell Adenoma|Pituitary Basophilic Adenoma	Pituitary adenomas comprise approximately 10% of intracranial neoplasms.  Pituitary may be classified on the basis of their anatomical, histological or functional characteristics.  Histologically pituitary tumors are divided into acidophilic, basophilic and chromophobe adenomas on the basis of conventional staining techniques. -2002
C2857	Pituitary_Gland_Chromophobe_Adenoma	Pituitary_Gland_Neoplasm_Antiquated	Pituitary Gland Chromophobe Adenoma|Chromophobe Adenoma|Chromophobe Adenoma of Pituitary Gland|Chromophobe Adenoma of the Pituitary Gland|Pituitary Chromophobe Adenoma
C2858	Adrenal_Cortex_Neoplasm	Adrenal_Gland_Neoplasm	Adrenal Cortex Neoplasm|Adrenal Cortex Tumor|Adrenocortical Neoplasm|Adrenocortical Tumor	A benign or malignant (primary or metastatic) neoplasm affecting the adrenal cortex. (NCI05)
C2859	Adrenal_Gland_Neoplasm	Adrenal_Gland_Disorder|Retroperitoneal_Neoplasm	Adrenal Gland Neoplasm|Adrenal Gland Tumor|Adrenal Neoplasm|Adrenal Neoplasms|Adrenal Tumor|Neoplasm of Adrenal Gland|Neoplasm of the Adrenal Gland|Tumor of Adrenal Gland|Tumor of the Adrenal Gland	A benign or malignant (primary or metastatic) neoplasm affecting the adrenal glands. (NCI05)
C2860	Adrenal_Rest_Neoplasm	Benign_Reproductive_System_Neoplasm	Adrenal Rest Tumor|Adrenal Rest Neoplasm	A benign, testicular or ovarian tumor, derived from adrenal embryonic rest cells. It is composed of hyperplastic adrenal cortical tissue, and it is associated with congenital adrenal hyperplasia. --2005
C2861	Side_Effect	Finding_by_Cause	Side Effect|side effects	An unwanted effect caused by a drug or therapy.  Such effects can be drug related, dose related, route related, patient related, caused by an interaction with another drug, or caused by opioid initiation or dose escalation.
C2862	Chronic_Idiopathic_Myelofibrosis	Chronic_Myeloproliferative_Disorder|Myelofibrosis	Chronic Idiopathic Myelofibrosis|Agnogenic Myeloid Metaplasia|Idiopathic Bone Marrow Fibrosis|Idiopathic Myelofibrosis|Myelosclerosis with Myeloid Metaplasia|Primary Myelofibrosis|idiopathic myelofibrosis	A chronic myeloproliferative disorder characterized by bone marrow fibrosis, proliferation of atypical megakaryocytes and granulocytes in the bone marrow, anemia, splenomegaly, and extramedullary hematopoiesis.  The cause is unknown.  The median survival time is 3-5 years from diagnosis. (WHO, 2001) -- 2003
C2863	Granulocytopenia	Leukopenia	Granulocytopenia|Neutropenia|granulocytopenia|neutropenia	A decrease in the number of mature granulocytes (neutrophils, eosinophils, and basophils) in the peripheral blood. -- 2004
C2864	AIDS_Dementia	AIDS_Encephalopathy	AIDS Dementia	neurological complications characterized by abnormalities in cognition, motor performance, and behavior due to HIV infection.
C2865	Alopecia	Non-Neoplastic_Hair_Disorder	Alopecia|alopecia	(al-oh-PEE-shuh) The lack or loss of hair from areas of the body where hair is usually found. Alopecia can be a side effect of some cancer treatments.
C2866	Alzheimer_s_Disease	Dementia	Alzheimer's Disease|Alzheimer's Dementia	A progressive, neurodegenerative disease characterized by loss of function and death of nerve cells in several areas of the brain leading to loss of cognitive function such as memory and language.
C2867	Amnesia	Mental_and_Behavioral_Signs_and_Symptoms	Amnesia	Systematic and extensive loss of memory caused by organic or psychological factors. The loss may be temporary or permanent, and may involve old or recent memories.
C2868	Amyloidosis	Cancer-Related_Condition	Amyloidosis|amyloidosis	A group of diseases in which protein is deposited in specific organs (localized amyloidosis) or throughout the body (systemic amyloidosis). Amyloidosis may be either primary (with no known cause) or secondary (caused by another disease, including some types of cancer). Generally, primary amyloidosis affects the nerves, skin, tongue, joints, heart, and liver; secondary amyloidosis often affects the spleen, kidneys, liver, and adrenal glands.
C2869	Anemia	Hematologic_Disorder	Anemia|anemia	(a-NEE-mee-a) A condition in which the number of red blood cells is below normal.
C2870	Aplastic_Anemia	Anemia	Aplastic Anemia|aplastic anemia	A condition in which the bone marrow is unable to produce blood cells.
C2871	Pernicious_Anemia	Megaloblastic_Anemia	Pernicious Anemia|pernicious anemia	(per-NISH-us a-NEE-mee-a) A type of anemia (low red blood cell count) caused by the body's inability to absorb vitamin B12.
C2872	Refractory_Anemia	Myelodysplastic_Syndrome	Refractory Anemia|Aregenerative Anemia|RA	A myelodysplastic syndrome characterized mainly by dysplasia of the erythroid series.  Refractory anemia is uncommon.  It is primarily a disease of older adults.  The median survival exceeds 5 years.  (WHO, 2001) -- 2003
C2873	Aneuploidy	Numerical_Chromosome_Aberration	Aneuploidy|ANPDY	A chromosomal abnormality in which there is an addition or loss of chromosomes within a set (e.g., 23 + 22 or 23 + 24).
C2874	Angiokeratoma	Vascular_Ectasia	Angiokeratoma
C2875	Anorexia	Nutritional_Disorder	Anorexia|anorexia	An abnormal loss of the appetite for food.  Anorexia can be caused by cancer, AIDS, a mental disorder (i.e., anorexia nervosa), or other diseases.
C2876	Anoxia	Hypoxia	Anoxia	Absence or reduction of oxygen in body tissue. (PSY94)
C2877	Anal_Neoplasm	Anal_Disorder|Gastrointestinal_Neoplasm	Anal Neoplasm|Anal Neoplasms, Benign and Malignant|Anal Tumor|Anal Tumors|Neoplasm of Anus|Neoplasm of the Anus|Tumor of Anus|Tumor of the Anus	An abnormal growth of cells at or near the anus
C2878	Anxiety_Disorder	Psychiatric_Disorder	Anxiety Disorder	general term for the group of specific, anxiety-related, avoidance- prone disorders listed as NTs.
C2879	Neoplasm_of_the_Diffuse_Neuroendocrine_System	Neuroendocrine_Neoplasm	Neoplasm of the Diffuse Neuroendocrine System|APUDoma|Apudoma|Neoplasm of Diffuse Neuroendocrine System|Tumor of Diffuse Neuroendocrine System|Tumor of the Diffuse Neuroendocrine System	A tumor made up of cells with APUD properties. - 2002
C2880	Androblastoma	Ovarian_Sertoli-Stromal_Cell_Tumor	Ovarian Sertoli-Leydig Cell Tumor|Androblastoma of Ovary|Androblastoma of the Ovary|Arrhenoblastoma of Ovary|Arrhenoblastoma of the Ovary|Ovarian Androblastoma|Ovarian Arrhenoblastoma|Ovarian Sertoli-Leydig Cell Neoplasm|Sertoli-Leydig Cell Tumor of Ovary|Sertoli-Leydig Cell Tumor of the Ovary|Sertoli-Leydig Neoplasm of Ovary|Sertoli-Leydig Neoplasm of the Ovary
C2881	Arrhythmia	Non-Neoplastic_Heart_Disorder	Arrhythmia|ARHY|Cardiac Arrhythmia	An abnormal rate of muscle contractions in the heart.
C2882	Arteriovenous_Malformation	Congenital_Abnormality	Arteriovenous Malformation
C2883	Arthritis	Arthropathy	Arthritis|arthritis	A disease marked by inflammation and pain in the joints.
C2884	Rheumatoid_Arthritis	Arthritis|Autoimmune_Disease|Rheumatologic_Disorder	Rheumatoid Arthritis	A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
C2885	Ascites	Peritoneal_Disorder	Ascites|ascites	(ah-SYE-teez) Abnormal buildup of fluid in the abdomen.
C2886	Aspergillosis	Fungal_Infection	Aspergillosis|aspergillosis	An infectious fungal disease that occurs most often in the skin, ears, nasal sinuses, and lungs of people with suppressed immune systems.
C2887	Ataxia_Telangiectasia_Syndrome	Congenital_Combined_Immunodeficiency|DNA_Repair_Disorder|Hereditary_Neoplastic_Syndrome	Ataxia Telangiectasia Syndrome|Ataxia Telangiectasia|Louis-Bar Syndrome	Rare hereditary disease characterized by extreme sensitivity to ionizing radiation or radiomimetic drugs because of a defect in DNA repair. AT heterozygosity is estimated to occur in more than 2% of the U.S. population; heterozygotes exhibit increased radiation sensitivity and are at increased risk for several types of cancer. The normal version of the gene that is defective in AT appears to activate the p53-dependent response to DNA damage.
C2888	Atelectasis	Non-Neoplastic_Lung_Disorder	Atelectasis|ATLEC|atelectasis	(at-uh-LEK-tuh-sis) Failure of the lung to expand (inflate) completely. This may be caused by a blocked airway, a tumor, general anesthesia, pneumonia or other lung infections, lung disease, or long-term bedrest with shallow breathing.  Sometimes called a collapsed lung.
C2889	Autoimmune_Disease	Immune_System_Disorder	Autoimmune Disease|Autoimmune Diseases|Autoimmune Disorder|Autoimmune Disorders|autoimmune disease	A condition in which the body recognizes its own tissues as foreign and directs an immune response against them.
C2890	Bacterial_Infection	Infectious_Disorder	Bacterial Infection	infections and associated diseases by bacteria, general or unspecified.
C2891	Barrett_s_Esophagus	Esophageal_Precancerous_Condition	Barrett's Esophagus|BE|Barrett's esophagus|CELLO|CLE|Columnar Epithelial-Lined Lower Esophagus|Columnar-Lined Esophagus	A condition in which the cells lining the lower part of the esophagus have changed or been replaced with abnormal cells that could lead to cancer of the esophagus. The backing up of stomach contents (reflux) may irritate the esophagus and, over time, cause Barrett's esophagus.
C2892	Basal_Cell_Nevus_Syndrome	Hereditary_Neoplastic_Syndrome	Nevoid Basal Cell Carcinoma Syndrome|Basal Cell Nevus Syndrome|Gorlin Syndrome|Gorlin-Goltz Syndrome|basal cell nevus syndrome	An inherited condition that causes unusual facial features and disorders of the skin, bone, nervous system, eyes, and endocrine glands. People with this syndrome have an increased chance of developing basal cell carcinoma. Also called Gorlin syndrome.
C2893	Psychiatric_Disorder	Diseases_and_Disorders	Psychiatric Disorder|Mental Illness|Psychiatric Disease	broad class of abnormalities of thought, feeling, and behavior, resulting in distress or impairment.
C2894	Benign_Colon_Neoplasm	Benign_Colorectal_Neoplasm|Colon_Neoplasm	Benign Colon Neoplasm|Benign Colon Tumor|Benign Colonic Neoplasm|Benign Colonic Tumor|Benign Neoplasm of Colon|Benign Neoplasm of the Colon|Benign Tumor of Colon|Benign Tumor of the Colon	This is a non-cancerous growth of tissue originating in the colon.
C2895	Benign_Ovarian_Neoplasm	Benign_Female_Reproductive_System_Neoplasm|Ovarian_Neoplasm	Benign Ovarian Neoplasm|Benign Neoplasm of Ovary|Benign Neoplasm of the Ovary|Benign Ovarian Tumor|Benign Tumor of Ovary|Benign Tumor of the Ovary
C2896	Benign_Skin_Neoplasm	Skin_Neoplasm	Benign Skin Neoplasm|Benign Cutaneous Neoplasm|Benign Cutaneous Tumor|Benign Neoplasm of Skin|Benign Neoplasm of the Skin|Benign Skin Tumor|Benign Tumor of Skin|Benign Tumor of the Skin|Skin Neoplasms, Benign	Abnormal growth of the cells that comprise the tissues of the skin, without any evidence of malignancy.
C2897	Benign_Prostatic_Hyperplasia	Hyperplasia	Benign Prostatic Hyperplasia|BPH|Benign Hyperplasia of Prostate|Benign Hyperplasia of the Prostate|Benign Prostate Hyperplasia|Benign Prostatic Hypertrophy|benign prostatic hyperplasia|benign prostatic hypertrophy	(hye-per-PLAY-zha) A benign (noncancerous) condition in which an overgrowth of prostate tissue pushes against the urethra and the bladder, blocking the flow of urine.
C2898	Bile_Duct_Neoplasm	Biliary_Tract_Disorder|Hepato-Biliary_Neoplasm	Biliary Tract Neoplasm|Bile Duct Neoplasm|Bile Duct Tumor|Biliary Neoplasm|Intrahepatic and Extrahepatic Bile Duct Neoplasm|Intrahepatic and Extrahepatic Bile Duct Tumor	Benign and malignant neoplasms which form in the biliary tree, which includes the bile ducts and gall bladder. - 2003
C2899	Biliary_Tract_Disorder	Liver_and_Biliary_Tract_Disorder	Biliary Tract Disorder|Biliary Tract Disease
C2900	Bladder_Disorder	Urinary_Tract_Disorder	Bladder Disorder|Urinary Bladder Disorder	A non-neoplastic or neoplastic disorder affecting the urinary bladder.  A representative example of non-neoplastic bladder disorder is bacterial bladder infection.  A representative example of neoplastic bladder disorder is bladder carcinoma. -- 2003
C2901	Bladder_Neoplasm	Bladder_Disorder|Urinary_Tract_Neoplasm	Bladder Neoplasm|Bladder Tumor|Bladder Tumors|Neoplasm of Bladder|Neoplasm of Urinary Bladder|Neoplasm of the Bladder|Neoplasm of the Urinary Bladder|Tumor of Bladder|Tumor of Urinary Bladder|Tumor of the Bladder|Tumor of the Urinary Bladder|Urinary Bladder Neoplasm|Urinary Bladder Neoplasms|Urinary Bladder Tumor|Urinary Bladder Tumors	A benign or malignant, primary or metastatic neoplasm of the bladder. - 2003
C2902	Coagulation_Disorder	Non-Neoplastic_Hematologic_Disorder	Coagulation Disorder|Coagulopathy
C2903	Bloom_Syndrome	Hereditary_Neoplastic_Syndrome	Bloom Syndrome|Congenital Telangiectatic Erythema Syndrome	Bloom syndrome is an autosomal recessive disorder associated with mutations in BLM gene encoding protein that belongs to the family of DNA helicases. It is characterized by predisposition to cancer, immunodeficiency, high sensitivity to UV and genomic instability of somatic cells. (Oncogene 2001 Dec 13;20(57):8276-80)
C2904	Bone_Cyst	Cyst	Bone Cyst|Cyst of Bone|Cyst of the Bone|Simple Bone Cyst|Solitary Bone Cyst|Solitary Cyst|Unicameral Bone Cyst
C2905	Bone_Marrow_Hyperplasia	Hyperplasia	Bone Marrow Hyperplasia|Hematopoietic Cell Proliferation|Hyperplasia of Bone Marrow|Marrow Hyperplasia
C2906	Skin_Squamous_Cell_Carcinoma_in_situ	Skin_Squamous_Cell_Carcinoma|Stage_0_Skin_Cancer	Skin Squamous Cell Carcinoma In Situ|Bowen's Disease of the Skin|Bowen's disease|Intraepidermal Squamous Cell Carcinoma|Intraepidermal Squamous Cell Carcinoma, Bowen's Type|Squamous Cell Carcinoma in situ of Skin|Squamous Cell Carcinoma in situ of the Skin	(BO-uns disease) A skin disease marked by scaly or thickened patches on the skin and often caused by prolonged exposure to arsenic.  The patches often occur on sun-exposed areas of the skin and in older, white men.  These patches may become malignant (cancerous).  Also called precancerous dermatosis or precancerous dermatitis.
C2907	Brain_Neoplasm	Intracranial_Neoplasm	Brain Neoplasm|Brain Neoplasms|Brain Tumor|Neoplasm of Brain|Neoplasm of the Brain|Tumor of Brain|Tumor of the Brain	Benign and malignant neoplasms that arise from or metastasize to structures within the cranium.  This includes meningeal and other tumors that occur in the spaces that surround the brain, and neoplasms of the brain.
C2908	Branchial_Cyst	Cyst	Branchial Cyst|Branchial Cleft Cyst|Branchioma|Cyst of Branchial Cleft|Cyst of the Branchial Cleft
C2909	Non-Neoplastic_Breast_Disorder	Breast_Disorder	Non-Neoplastic Breast Disorder|Non-Neoplastic Breast Disease|Non-Neoplastic Disease of Breast|Non-Neoplastic Disease of the Breast
C2910	Breast_Neoplasm	Breast_Disorder|Neoplasm_by_Site	Breast Neoplasm|Breast Tumor|Neoplasm of Breast|Neoplasm of the Breast|Tumor of Breast|Tumor of the Breast	A benign or malignant neoplasm of the breast parenchyma.  It can originate from the ducts, lobules or the breast adipose tissue.  Breast neoplasms are much more common in females than males. -- 2003
C2911	Bronchitis	Non-Neoplastic_Lung_Disorder	Bronchitis|bronchitis	(bron-KYE-tis) Inflammation (swelling and reddening) of the bronchi.
C2912	Burkitt_s_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Burkitt's Lymphoma|Burkitt Lymphoma/Leukemia|Burkitt's Lymphoma/Leukemia|Burkitt's lymphoma|Small Non-Cleaved Cell Lymphoma, Burkitt's Type	A highly aggressive lymphoma composed of monomorphic medium-sized B-cells with basophilic cytoplasm and numerous mitotic figures.  It is often associated with the presence of Epstein-Barr virus (EBV) and is commonly seen in AIDS patients.  Three morphologic variants are recognized: classical Burkitt's lymphoma, Burkitt's lymphoma with plasmacytoid differentiation, and atypical Burkitt's/Burkitt's-like lymphoma.  All cases express the MYC translocation [t(8;14)]. (WHO, 2001) -- 2003
C2913	Cachexia	Symptom	Cachexia|cachexia	The loss of body weight and muscle mass frequently seen in patients with cancer, AIDS, or other diseases.
C2914	Vulvovaginal_Candidiasis	Candidiasis	Vulvovaginal Candidiasis	Infection of the vulva and vagina with a fungus of the genus CANDIDA.  It is a disease associated with HIV infection.
C2915	Carcinoid_Tumor	Neoplasm_of_the_Diffuse_Neuroendocrine_System|Neuroendocrine_Carcinoma	Carcinoid Tumor|Carcinoid|Carcinoid Neoplasm|Well-Differentiated Endocrine Neoplasm|carcinoid	(KAR-sin-oyd) A type of tumor usually found in the gastrointestinal system (most often in the appendix), and sometimes in the lungs or other sites.  Carcinoid tumors are usually benign.
C2916	Carcinoma	Epithelial_Neoplasm	Carcinoma|CA|Epithelial Carcinoma|Malignant Epithelial Neoplasm|Malignant Epithelial Tumor|carcinoma|epithelial carcinoma	(ep-ih-THEE-lee-ul kar-sin-O-ma) Cancer that begins in the cells that line an organ.
C2917	Carcinoma_in_situ	Carcinoma|Cellular_Precursor_of_Cancer	Carcinoma In Situ|CIS|Intraepithelial Carcinoma|carcinoma in situ|in situ cancer	(kar-sin-O-ma in SYE-too) Cancer that involves only the cells in which it began and that has not spread to neighboring tissues.
C2918	Female_Breast_Carcinoma	Breast_Carcinoma	Female Breast Carcinoma|Breast Carcinoma, Female|Carcinoma of Female Breast|Carcinoma of the Female Breast|Female Breast Cancer|Mammary Carcinoma of Female Breast|Mammary Carcinoma of the Female Breast
C2919	Prostate_Adenocarcinoma	Adenocarcinoma|Common_Carcinoma|Prostate_Carcinoma	Prostate Adenocarcinoma|Adenocarcinoma of Prostate|Adenocarcinoma of the Prostate	Prostate adenocarcinoma is one of the most common malignant tumors afflicting men.  The majority of adenocarcinomas arise in the peripheral zone and a minority occur in the central or the transitional zone of the prostate gland.  Grading of prostatic adenocarcinoma predicts disease progression and correlates with survival.  Several grading systems have been proposed, of which the Gleason system is the most commonly used.  Gleason sums of 2 to 4 represent well-differentiated disease, 5 to 7 moderately differentiated disease and 8 to 10 poorly differentiated disease.  Prostatic-specific antigen (PSA) serum test is widely used as a screening test for the early detection of prostatic adenocarcinoma.  Treatment options include radical prostatectomy, radiation therapy, androgen ablation and cryotherapy.  Watchful waiting or surveillance alone is an option for older patients with low-grade or low-stage disease. --2002
C2920	Malignant_Skin_Neoplasm	Skin_Neoplasm	Malignant Skin Neoplasm|Malignant Neoplasm of Skin|Malignant Neoplasm of the Skin|Malignant Skin Tumor|Malignant Tumor of Skin|Malignant Tumor of the Skin|Melanoma and Non-Melanoma Skin Cancer|Skin Cancer, Including Melanoma|Skin Cancers|Skin Neoplasms, Malignant	A primary or metastatic tumor involving the skin.  Primary malignant skin tumors most often are carcinomas (either basal cell or squamous cell carcinomas that arise from cells in the epidermis) or melanomas that arise from pigment-containing skin melanocytes.  Metastatic tumors to the skin include carcinomas and lymphomas. -- 2004
C2921	Basal_Cell_Carcinoma	Common_Carcinoma|Malignant_Basal_Cell_Neoplasm|Skin_Carcinoma	Skin Basal Cell Carcinoma|BCC|Basal Cell Cancer|Basal Cell Carcinoma|Basal Cell Carcinoma of Skin|Basal Cell Carcinoma of the Skin|Basal Cell Epithelioma|Basal Cell Skin Carcinoma|Basiloma|Rodent Ulcer|basal cell carcinoma	(BAY-sal sel kar-sin-O-ma) A type of skin cancer that arises from the basal cells, small round cells found in the lower part (or base) of the epidermis, the outer layer of the skin.
C2922	Basosquamous_Cell_Carcinoma	Basal_Cell_Carcinoma	Skin Basosquamous Cell Carcinoma|Skin Metatypical Basal Cell Carcinoma|Skin Metatypical Carcinoma|Skin Mixed Basal and Squamous Cell Carcinoma
C2923	Bronchiolo-Alveolar_Lung_Carcinoma	Lung_Adenocarcinoma	Bronchioloalveolar Carcinoma|Bronchioalveolar Adenocarcinoma of Lung|Bronchioalveolar Adenocarcinoma of the Lung|Bronchioalveolar Lung Carcinoma|Bronchiolo-Alveolar Carcinoma of Lung|Bronchiolo-Alveolar Carcinoma of the Lung|Bronchiolo-Alveolar Lung Carcinoma|Bronchioloalveolar Adenocarcinoma of Lung|Bronchioloalveolar Adenocarcinoma of the Lung|Bronchioloalveolar Lung Adenocarcinoma	A well differentiated morphologic variant of lung adenocarcinoma characterized by the presence of alveolar structures without stromal, vascular, or pleural invasion. (NCI05)
C2924	Ductal_Carcinoma_in_situ_of_the_Breast	Ductal_Breast_Carcinoma|Mammary_Intraepithelial_Neoplasia_Ductal_Type|Stage_0_Breast_Cancer	Ductal Breast Carcinoma In Situ|DCIS|Ductal Breast Carcinoma in Situ|Ductal Carcinoma in situ|Ductal Carcinoma in situ of Breast|Ductal Carcinoma in situ of the Breast|Intraductal Breast Carcinoma|Intraductal Carcinoma|Intraductal Carcinoma of Breast|Intraductal Carcinoma of the Breast|Non-Infiltrating Ductal Adenocarcinoma of Breast|Non-Infiltrating Ductal Adenocarcinoma of the Breast|Non-Infiltrating Ductal Breast Adenocarcinoma|Non-Infiltrating Ductal Breast Carcinoma|Non-Infiltrating Ductal Carcinoma of Breast|Non-Infiltrating Ductal Carcinoma of the Breast|Non-Infiltrating Intraductal Adenocarcinoma|Non-Infiltrating Intraductal Adenocarcinoma of Breast|Non-Infiltrating Intraductal Adenocarcinoma of the Breast|Non-Infiltrating Intraductal Breast Adenocarcinoma|Non-Infiltrating Intraductal Carcinoma|Non-Invasive Ductal Adenocarcinoma of Breast|Non-Invasive Ductal Adenocarcinoma of the Breast|Non-Invasive Ductal Breast Adenocarcinoma|Non-Invasive Ductal Breast Carcinoma|Non-Invasive Ductal Carcinoma of Breast|Non-Invasive Ductal Carcinoma of the Breast|Non-Invasive Intraductal Adenocarcinoma of Breast|Non-Invasive Intraductal Adenocarcinoma of the Breast|Non-Invasive Intraductal Breast Adenocarcinoma|ductal carcinoma in situ|intraductal carcinoma	(DUK-tal kar-sin-O-ma in SYE-too) DCIS. Abnormal cells that involve only the lining of a duct. The cells have not spread outside the duct to other tissues in the breast. Also called intraductal carcinoma.
C2926	Non-Small_Cell_Lung_Carcinoma	Common_Carcinoma|Lung_Carcinoma	Non-Small Cell Lung Carcinoma|NSCLC|NSCLC - Non-Small Cell Lung Cancer|Non Small Cell Lung Cancer NOS|Non-Small Cell Cancer of Lung|Non-Small Cell Cancer of the Lung|Non-Small Cell Carcinoma of Lung|Non-Small Cell Carcinoma of the Lung|Non-Small Cell Lung Cancer|non-small cell lung cancer	A group of at least three distinct histological types of lung cancer, including squamous cell carcinoma, adenocarcinoma, and large cell carcinoma.  Non-small cell lung carcinomas have a poor response to conventional chemotherapy.  --2002
C2927	Papillary_Carcinoma	Carcinoma|Papillary_Epithelial_Neoplasm	Papillary Carcinoma
C2928	Scirrhous_Adenocarcinoma	Adenocarcinoma	Scirrhous Adenocarcinoma|Adenocarcinoma with Productive Fibrosis
C2929	Squamous_Cell_Carcinoma	Carcinoma|Malignant_Squamous_Cell_Neoplasm	Squamous Cell Carcinoma|Epidermoid Carcinoma|Squamous Carcinoma|epidermoid carcinoma|squamous cell carcinoma	(SKWAY-mus sel kar-sin-O-ma) Cancer that begins in squamous cells, which are thin, flat cells that look like fish scales. Squamous cells are found in the tissue that forms the surface of the skin, the lining of the hollow organs of the body, and the passages of the respiratory and digestive tracts. Also called epidermoid carcinoma.
C2930	Transitional_Cell_Carcinoma	Carcinoma|Transitional_Cell_Neoplasm	Transitional Cell Carcinoma|Transitional Carcinoma|transitional cell carcinoma	A malignant neoplasm arising from the transitional epithelium, usually affecting the urinary bladder, ureter, or renal pelvis. It may or may not have a papillary configuration. It is graded 1 to 3 or 4 according to the degree of cellular differentiation and architectural patterns. Grade 1 transitional cell carcinoma is histologically benign but it may recur. Transitional cell carcinomas may also affect the upper respiratory tract and the ovaries. -- 2003
C2931	Cardiovascular_Disorder	Disorder_by_Site	Cardiovascular Disorder|Cardiovascular Disease|Cardiovascular Diseases|Cardiovascular Disorders	A non-neoplastic or neoplastic disorder affecting the heart or the vessels (arteries, veins and lymph vessels).  Representative examples of non-neoplastic cardiovascular disorders are endocarditis and hypertension.  Representative examples of neoplastic cardiovascular disorders are endocardial myxoma and angiosarcoma. -- 2003
C2932	Carotid_Body_Paraganglioma	Head_and_Neck_Paraganglioma|Parasympathetic_Paraganglioma	Carotid Body Paraganglioma|Carotid Body Chemodectoma|Carotid Body Tumor|Chemodectoma|Paraganglioma of Carotid Body|Paraganglioma of the Carotid Body|Tumor of Carotid Body|Tumor of the Carotid Body	A benign or malignant extra-adrenal parasympathetic paraganglioma arising from paraganglia adjacent to or in the bifurcation of the common carotid artery.  Most patients present with a slow growing, painless mass in the neck.
C2933	Cementoma	Benign_Odontogenic_Neoplasm	Cementoma|Periapical Cemental Dysplasia|Periapical Cemento-Osseous Dysplasia
C2934	Central_Nervous_System_Disorder	Nervous_System_Disorder	Central Nervous System Disorder|Central Nervous System Disease
C2935	Cerebellar_Neoplasm	Infratentorial_Neoplasm	Cerebellar Neoplasm|Cerebellar Tumor|Neoplasm of Cerebellum|Neoplasm of the Cerebellum|Tumor of Cerebellum|Tumor of the Cerebellum	A benign or malignant (primary or metastatic) tumor involving the cerebellum. -- 2003
C2936	Cerebral_Arteriovenous_Malformation	Arteriovenous_Malformation|Central_Nervous_System_Vascular_Malformation	Cerebral Arteriovenous Malformation
C2937	Intraventricular_Brain_Neoplasm	Brain_Neoplasm	Intraventricular Brain Neoplasm|Brain Neoplasms, Intraventricular|Intraventricular Brain Neoplasms|Intraventricular Brain Tumor|Intraventricular Neoplasm of Brain|Intraventricular Neoplasm of the Brain|Intraventricular Neoplasms|Intraventricular Tumor of Brain|Intraventricular Tumor of the Brain
C2938	Cerebrovascular_Disorder	Non-Neoplastic_Central_Nervous_System_Disorder|Non-Neoplastic_Vascular_Disorder	Cerebrovascular Disorder|Cerebrovascular Disease
C2939	Cervical_Polyp	Cervical_Disorder|Uterine_Polyp	Cervical Polyp|Adenomatous Polyp of Cervix|Adenomatous Polyp of Uterine Cervix|Adenomatous Polyp of the Cervix|Adenomatous Polyp of the Uterine Cervix|Cervix Adenomatous Polyp|Cervix Polyp|Cervix Uteri Adenomatous Polyp|Cervix Uteri Polyp|Polyp of Cervix|Polyp of Cervix Uteri|Polyp of Uterine Cervix|Polyp of the Cervix|Polyp of the Cervix Uteri|Polyp of the Uterine Cervix|Uterine Cervix Adenomatous Polyp|Uterine Cervix Polyp	A polyp that arises from the glandular epithelium of the cervix. -- 2003
C2940	Cervical_Neoplasm	Cervical_Disorder|Uterine_Neoplasm	Cervical Neoplasm|Cervical Tumor|Cervix Neoplasm|Cervix Tumor|Cervix Uteri Neoplasm|Cervix Uteri Tumor|Neoplasm of Cervix|Neoplasm of Cervix Uteri|Neoplasm of Uterine Cervix|Neoplasm of the Cervix|Neoplasm of the Cervix Uteri|Neoplasm of the Uterine Cervix|Tumor of Cervix|Tumor of Cervix Uteri|Tumor of Uterine Cervix|Tumor of the Cervix|Tumor of the Cervix Uteri|Tumor of the Uterine Cervix|Uterine Cervix Neoplasm|Uterine Cervix Tumor	Abnormal growth in the cervix, which can be benign (non cancerous) or malignant (cancerous )
C2941	Chediak-Higashi_Syndrome	Congenital_Disorder_of_Natural_Immunity	Chediak-Higashi Syndrome	A rare autosomal recessive immunodeficiency disorder characterized by abnormal intracellular protein transport. Chediak-Higashi syndrome (CHS) is characterized by immune deficiency; partial oculocutaneous albinism; a bleeding disorder due to deficient platelet dense bodies; neutropenia; neutrophils with impaired chemotaxis and bactericidal activity; recurrent infection; and abnormal natural killer (NK) cell function. CHS may be associated with hepatosplenomegaly, lymphadenopathy, anemia, thrombocytopenia, roentgenologic changes in bones, lungs and heart, and skin and psychomotor abnormalities; it is often fatal in childhood as a result of infection or an accelerated lymphoma-like phase. CHS occurs in mink, cattle, and mice, as well as man. --2004
C2942	Bile_Duct_Adenoma	Adenoma|Bile_Duct_Neoplasm	Bile Duct Adenoma|Adenoma of Bile Duct|Adenoma of the Bile Duct|Cholangioadenoma
C2943	Choledochal_Cyst	Cyst|Gastrointestinal_System_Finding	Choledochal Cyst
C2944	Cholesteatoma	Non-Neoplastic_Head_and_Neck_Disorder	Cholesteatoma
C2945	Chondroblastoma	Benign_Chondrogenic_Neoplasm	Chondroblastoma
C2946	Chondrosarcoma	Chondrogenic_Neoplasm|Infrequent_Neoplasm|Sarcoma_of_the_Soft_Tissue_and_Bone	Chondrosarcoma|chondrosarcoma	(KAHN-dro-sar-KO-ma) A type of cancer that forms in cartilage.
C2947	Chordoma	Notochordal_Neoplasm	Chordoma|chordoma	(kor-DO-ma) A type of bone cancer that usually starts in the lower spinal cord.
C2948	Choriocarcinoma	Malignant_Germ_Cell_Neoplasm|Trophoblastic_Neoplasm	Choriocarcinoma|Chorioepithelioma|choriocarcinoma	A rare cancer in women of childbearing age in which cancer cells grow in the tissues that are formed in the uterus after conception. Also called gestational trophoblastic disease, gestational trophoblastic neoplasia, gestational trophoblastic tumor, or molar pregnancy.
C2949	Choroid_Neoplasm	Choroid_Disorder|Uveal_Neoplasm	Choroid Neoplasm|Choroid Tumor|Choroidal Neoplasm|Choroidal Tumor|Neoplasm of Choroid|Neoplasm of the Choroid|Tumor of Choroid|Tumor of the Choroid
C2950	Chromosomal_Aberration	Molecular_Abnormality	Cytogenetic Abnormality|Aberrant Chromosome|Chromosomal Aberration|Chromosomal Abnormalities|Chromosomal Abnormality|Chromosomal Alterations|Chromosome Aberration|Chromosome Abnormality|Chromosome Alterations|Chromosome Anomalies|Cytogenetic Aberration	An irregularity in the number or structure of chromosomes, usually in the form of a gain (duplication), loss (deletion), exchange (translocation), or alteration in sequence (inversion) of genetic material.
C2951	Cirrhosis	Hepatocellular_Damage	Cirrhosis|Liver Cirrhosis|cirrhosis	A type of chronic, progressive liver disease in which liver cells are replaced by scar tissue.
C2952	Ulcerative_Colitis	Inflammatory_Bowel_Disease	Ulcerative Colitis|ulcerative colitis	Chronic inflammation of the colon that produces ulcers in its lining.  This condition is marked by abdominal pain, cramps, and loose discharges of pus, blood, and mucus from the bowel.
C2953	Colon_Neoplasm	Colorectal_Neoplasm	Colon Neoplasm|Colon Tumor|Colonic Neoplasm|Colonic Tumor|Neoplasm of Colon|Neoplasm of the Colon|Tumor of Colon|Tumor of the Colon	A benign or malignant tumor involving the colon. -- 2003
C2954	Colon_Polyp	Colorectal_Polyp	Colon Polyp|Colonic Polyp|Polyp of Colon|Polyp of the Colon|colon polyps	Abnormal growths of tissue in the lining of the bowel.  Polyps are a risk factor for colon cancer.
C2955	Colorectal_Carcinoma	Carcinoma|Common_Carcinoma|Malignant_Colorectal_Neoplasm	Colorectal Carcinoma|Cancer of Large Bowel|Cancer of Large Intestine|Cancer of the Large Bowel|Cancer of the Large Intestine|Carcinoma of Large Bowel|Carcinoma of Large Intestine|Carcinoma of the Large Bowel|Carcinoma of the Large Intestine|Colorectal Cancer|Large Bowel Cancer|Large Bowel Carcinoma|Large Intestine Cancer|Large Intestine Carcinoma
C2956	Colorectal_Neoplasm	Intestinal_Neoplasm	Colorectal Neoplasm|Colorectal Tumor|Large Bowel Neoplasm|Large Bowel Tumor|Large Intestine Neoplasm|Large Intestine Tumor|Neoplasm of Large Bowel|Neoplasm of the Large Bowel|Tumor of Large Bowel|Tumor of the Large Bowel	Benign or malignant abnormal growth in the colon or rectum.
C2958	Communication_Disorder	Socialized_Conduct_Disorder	Communication Disorder|Communicative Disorders	A disorder characterized by an individual's inability to comprehend or share ideas or feelings because of an impairment in language, speech, or hearing. --2004
C2959	Complication	Other_Finding	Complication|CM	Any disease or disorder that occurs during the course of (or because of) another disease.
C2960	Condyloma_Acuminatum	Squamous_Cell_Neoplasm	Condyloma Acuminatum|Genital Wart|Venereal Wart|condylomata acuminata	(kahn-dih-LO-ma-ta a-kyoo-mih-NA-ta) Genital warts caused by certain human papillomaviruses (HPVs).
C2961	Conjunctival_Neoplasm	Conjunctival_Disorder|Eye_Neoplasm	Conjunctival Neoplasm|Conjunctiva Neoplasm|Conjunctiva Tumor|Conjunctival Neoplasms|Conjunctival Tumor|Neoplasm of Conjunctiva|Neoplasm of the Conjunctiva|Tumor of Conjunctiva|Tumor of the Conjunctiva
C2962	Seizure	Neurological_Signs_and_Symptoms	Seizure|Convulsion|seizures	(SEE-zhurz) Convulsions; sudden, involuntary movements of the muscles.
C2963	Cranial_Nerve_Neoplasm	Cranial_Nerve_Disorder|Nervous_System_Neoplasm	Cranial Nerve Neoplasm|Cranial Nerve Neoplasms|Cranial Nerve Tumor|Neoplasm of Cranial Nerve|Neoplasm of the Cranial Nerve|Tumor of Cranial Nerve|Tumor of the Cranial Nerve	Abnormal growth of the cells that comprise the cranial nerves.
C2964	Craniopharyngioma	Benign_Intracranial_Neoplasm|Epithelial_Neoplasm|Infrequent_Neoplasm|Sella_Turcica_Neoplasm	Craniopharyngioma|Neoplasm of Rathke's Pouch|Rathke's Pouch Neoplasm|Rathke's Pouch Tumor|Tumor of Rathke's Pouch|craniopharyngioma	(KRAY-nee-o-fah-rin-jee-O-ma) A benign brain tumor that may be considered malignant because it can damage the hypothalamus, the area of the brain that controls body temperature, hunger, and thirst.
C2965	Crohn_s_Disease	Inflammatory_Bowel_Disease	Crohn's Disease|Crohn's disease|Crohns Disease	A gastrointestinal disorder characterized by chronic inflammation involving all layers of the intestinal wall, noncaseating granulomas affecting the intestinal wall and regional lymph nodes, and transmural fibrosis. Crohn's disease most commonly involves the terminal ileum; the colon is the second most common site of involvement. --2004
C2967	Cryptococcosis	Fungal_Infection	Cryptococcosis	An acute or chronic, localized or disseminated infection by Cryptococcus neoformans.  Sites of involvement include the lungs, central nervous system and meninges, skin, and visceral organs.--2004
C2969	Cushing_s_Syndrome	Endocrine_Syndrome	Cushing's Syndrome
C2970	Adenoid_Cystic_Carcinoma	Carcinoma	Adenoid Cystic Carcinoma|Adenocystic Carcinoma|Cylindroid Adenocarcinoma|Cylindroma|adenoid cystic cancer	A malignant tumor arising from the epithelial cells, also known as cylindroma.  Microscopically, the neoplastic epithelial cells form cylindrical spatial configurations (cribriform or classic type of adenoid cystic carcinoma), cordlike structures (tubular type of adenoid cystic carcinoma), or solid structures (basaloid variant of adenoid cystic carcinoma).  Adenoid cystic carcinomas mostly occur in the salivary glands.  Other primary sites of involvement include the lacrimal gland, the larynx, and the lungs.  Adenoid cystic carcinomas spread along nerve sheaths, resulting in severe pain, and they tend to recur.  Lymph node metastases are unusual; hematogenous tumor spread is characteristic. -- 2004
C2971	Cystadenocarcinoma	Adenocarcinoma|Cystic_Neoplasm	Cystadenocarcinoma
C2972	Cystadenoma	Cystic_Neoplasm|Epithelial_Neoplasm	Cystadenoma|Cystoma
C2973	Mucinous_Cystadenoma	Cystadenoma|Mucinous_Neoplasm	Mucinous Cystadenoma|Mucinous Adenoma|Mucinous Cystoma|Pseudomucinous Cystadenoma
C2974	Papillary_Cystadenoma	Cystadenoma	Papillary Cystadenoma
C2975	Cystic_Fibrosis	Genetic_Disorder|Pancreatic_Disorder	Cystic Fibrosis|cystic fibrosis	A common hereditary disease in which exocrine (secretory) glands produce abnormally thick mucus. This mucus can cause problems in digestion, breathing, and body cooling.
C2976	Cystinosis	Genetic_Disorder|Non-Neoplastic_Renal_Disorder	Cystinosis	An autosomal recessive hereditary disorder characterized by defective transportation of cystine across the lysosomal membranes and systemic deposition of cystine crystals in the body.  It is associated with slight increase of the plasma cystine, cystinuria, aminoaciduria, glycosuria, polyuria, hypophosphatemia, rickets, and renal tubular dysfunction. --2004
C2977	Phyllodes_Tumor	Fibroepithelial_Neoplasm	Phyllodes Tumor|Cystosarcoma Phyllodes|Phyllodes Neoplasm|cystosarcoma phyllodes|phyllodes tumor	A type of tumor found in breast tissue.  It is often large and bulky and grows quickly. It is usually benign (not cancer), but may be malignant (cancer).
C2978	Cyst	Other_Finding	Cyst|cyst	(sist) A sac or capsule filled with fluid.
C2979	Cytopenia	Abnormal_Hematology_Test_Result	Cytopenia|cytopenia	A reduction in the number of blood cells.
C2980	Dysphagia	Gastrointestinal_System_Signs_and_Symptoms	Dysphagia|DYSPH|dysphagia	Difficulty swallowing.
C2981	Delirium	Mental_and_Behavioral_Signs_and_Symptoms	Delirium
C2982	Depression	Psychiatric_Disorder	Depression	A mental state of depressed mood characterised by feelings of sadness, despair and discouragement. (On-line Medical Dictionary)
C2983	Dermatitis	Dermatosis	Dermatitis|dermatitis	Inflammation of the skin.
C2984	Dermatosis_Papulosa_Nigra	Dermatitis	Dermatosis Papulosa Nigra
C2985	Diabetes_Mellitus	Endocrine_Pancreas_Disorder|Non-Neoplastic_Endocrine_Disorder	Diabetes Mellitus|Diabetes|diabetes|diabetes mellitus	(dye-a-BEE-teez) A disease in which the body does not properly control the amount of sugar in the blood. As a result, the level of sugar in the blood is too high. This disease occurs when the body does not produce enough insulin or does not use it properly.
C2986	Insulin_Dependent_Diabetes_Mellitus	Autoimmune_Disease|Diabetes_Mellitus	Insulin Dependent Diabetes Mellitus	Diabetes mellitus characterized by insulin deficiency, sudden onset, severe hyperglycemia, rapid progression to ketoacidosis, and death unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.
C2987	Diarrhea	Disturbance_in_Bowel_Function	Diarrhea	A condition of frequent and watery bowel movements.
C2989	DiGeorge_s_Syndrome	Congenital_T-Cell_Immunodeficiency	DiGeorge's Syndrome	a congenital anomaly characterized by immunodeficiency, abnormal facies, congenital heart disease, hypocalcemia, and increased susceptibility to infections. Pathologic characteristics include conotruncal abnormalities and absence or hypoplasia of thymus and parathyroid glands. DiGeorge syndrome is associated with abnormalities of chromosome 22. Also known as DiGeorge anomaly. --2004
C2990	Gastrointestinal_Disorder	Disorder_by_Site	Gastrointestinal Disorder|Digestive Diseases|Gastrointestinal Diseases and Manifestations	Diseases of the digestive tract (oral cavity to anus) and associated organs (salivary glands, liver, pancreas).
C2991	Diseases_and_Disorders	Diseases_Disorders_and_Findings	Diseases and Disorders|DZ|Disease|Diseases|Disorder|Disorders	Any abnormal condition of the body or mind that causes discomfort, dysfunction, or distress to the person affected or those in contact with the person. Sometimes the term is used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function. (from Wikipedia)
C2992	Disseminated_Intravascular_Coagulation	Hematologic_Disorder	Disseminated Intravascular Coagulation|DIC	A pathological process in the body where the blood starts to coagulate throughout the whole body. This depletes the body of its platelets and coagulation factors, and there is an increased the risk of hemorrhage.
C2993	Down_Syndrome	Genetic_Disorder|Syndrome	Down Syndrome|Down syndrome|Downs Syndrome	A chromosomal dysgenesis syndrome resulting from a triplication or translocation of chromosome 21. Down syndrome occurs in approximately 1:700 live births. Abnormalities are variable from individual to individual and may include mental retardation, retarded growth, flat hypoplastic face with short nose, prominent epicanthic skin folds, small low-set ears with prominent antihelix, fissured and thickened tongue, laxness of joint ligaments, pelvic dysplasia, broad hands and feet, stubby fingers, transverse palmar crease, lenticular opacities and heart disease. Patients with Down syndrome have an estimated 10 to 30-fold increased risk for leukemia; most have symptoms of Alzheimer's disease by age 40. Also known as trisomy 21 syndrome. --2004
C2994	Dumping_Syndrome	Non-Neoplastic_Gastrointestinal_Disorder|Stomach_Disorder	Dumping Syndrome|dumping syndrome	A group of symptoms that occur when food or liquid enters the small intestine too rapidly. These symptoms include cramps, nausea, diarrhea, and dizziness. Dumping syndrome sometimes occurs in people who have had a portion of their stomach removed.
C2995	Duodenal_Neoplasm	Small_Intestinal_Neoplasm	Duodenal Neoplasm|Duodenal Tumor|Neoplasm of Duodenum|Neoplasm of the Duodenum|Tumor of Duodenum|Tumor of the Duodenum
C2996	Dysgerminoma	Malignant_Germ_Cell_Neoplasm	Dysgerminoma	Dysgerminoma arises primarily in the ovaries, but can occur both primarily and secondarily at other sites, particularly CNS.
C2997	Dyspareunia	Genitourinary_Signs_and_Symptoms|Reproductive_System_Finding	Dyspareunia|DYSPN	Painful or difficult coitus. --2004
C2998	Dyspnea	Alteration_in_Respiration	Dyspnea|DYSP|dyspnea	Difficult, painful breathing or shortness of breath.
C2999	Dysuria	Genitourinary_Signs_and_Symptoms|Urinary_Tract_Finding	Dysuria|DYSUR	Difficulty or pain in urination.
C3000	Ear_Neoplasm	Ear_Disorder|Head_and_Neck_Neoplasm	Ear Neoplasm|Ear Neoplasms|Ear Tumor|Neoplasm of Ear|Neoplasm of the Ear|Tumor of Ear|Tumor of the Ear
C3001	Eczema	Dermatitis	Eczema
C3002	Edema	Swelling	Edema|ED|edema	(eh-DEE-ma) Swelling caused by excess fluid in body tissues.
C3003	Effusion	Fluid_and_Electrolyte_Manifestation	Effusion|EFF	A collection of fluid in a body cavity.  It may be the result of a non-neoplastic disorder (e.g. heart failure) or a tumor (e.g. carcinoma of the lung). -- 2003
C3004	Elliptocytosis	Abnormal_Hematology_Test_Result	Elliptocytosis
C3005	Tumor_Embolism	Pathologic_Process	Tumor Embolism	A Tumor Embolism involves sudden blockage of an artery by a clot or by other material from tumor fragments transported by the blood stream.
C3006	Experimental_Allergic_Encephalomyelitis	Experimental_Organism_Diagnoses	Experimental Allergic Encephalomyelitis|EAE	An autoimmune demyelinating disease of the central nervous system that is produced experimentally in animals by the injection of homogenised brain or spinal cord in Freund's adjuvant. Myelin basic protein appears to be the antigen that elicits the hypersensitivity immune response which is characterized by focal areas of lymphocyte and macrophage infiltration into the brain, associated with demyelination and destruction of the blood-brain barrier. Experimental allergic encephalomyelitis (EAE) is used as an animal model for demyelinating diseases of the human central nervous system such as multiple sclerosis. --2004
C3007	Enchondroma	Benign_Chondrogenic_Neoplasm	Chondroma|Central Chondroma|Enchondroma|enchondroma	(en-kon-DRO-ma) A benign (noncancerous) growth of cartilage in bones or in other areas where cartilage is not normally found.
C3008	Enchondromatosis	Non-Neoplastic_Bone_Disorder	Enchondromatosis|Ollier's Disease
C3009	Endocrine_Disorder	Disorder_by_Site	Endocrine Disorder|Endocrine Disease|Endocrine Diseases and Manifestations|Endocrine Disorders
C3010	Endocrine_Neoplasm	Endocrine_Disorder|Epithelial_Neoplasm|Neoplasm_by_Site	Endocrine Neoplasm|Endocrine System Neoplasm|Endocrine System Tumor|Endocrine Tumor	A benign or malignant neoplasm arising from the epithelial cells of an endocrine organ. --2003
C3011	Yolk_Sac_Tumor	Malignant_Germ_Cell_Neoplasm	Yolk Sac Tumor|Endodermal Sinus Neoplasm|Endodermal Sinus Tumor|Yolk Sac Neoplasm|Yolk Sac Tumour Site Unspecified	This is the most common malignant germ cell tumor in the pediatric population. Yolk sac tumors arise in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum. - 2002
C3012	Endometrial_Neoplasm	Endometrial_Disorder|Uterine_Corpus_Neoplasm	Endometrial Neoplasm|Endometrial Tumor|Endometrium Neoplasm|Endometrium Tumor|Neoplasm of Endometrium|Neoplasm of the Endometrium|Tumor of Endometrium|Tumor of the Endometrium	Tumor originating and limited to the endometrium at first stage
C3013	Endometrial_Hyperplasia	Hyperplasia	Endometrial Hyperplasia|Hyperplasia of Endometrium|Hyperplasia of the Endometrium	A proliferation of the endometrial cells resulting in glandular enlargement and budding.  The proliferation may or may not be associated with atypia of the endometrial cells.  When the hyperplastic changes are excessive, there is formation of complex epithelial structures (complex endometrial hyperplasia). --2003
C3014	Endometriosis	Female_Non-Neoplastic_Reproductive_System_Disorder	Endometriosis|endometriosis	(en-do-mee-tree-O-sis) A benign condition in which tissue that looks like endometrial tissue grows in abnormal places in the abdomen.
C3015	Eosinophilia	Abnormal_Hematology_Test_Result	Eosinophilia|eosinophilia	A condition in which the number of eosinophils (a type of white blood cell) in the blood is greatly increased. Eosinophilia is often a response to infection or allergens (substances that cause an allergic response).
C3016	Eosinophilic_Granuloma	Langerhans_Cell_Histiocytosis	Eosinophilic Granuloma|Eosinophilic Xanthomatous Granuloma	A clinical variant of Langerhans cell histiocytosis characterised by unifocal involvement of a bone (most often), skin, or lung.  Patients are usually older children or adults usually presenting with a lytic bone lesion.  The etiology is unknown.  Morphologically, eosinophilic granuloma is characterised by the presence of Langerhans cells in a characteristic milieu which includes histiocytes, eosinophiles neutrophiles, and small, mature lymphocytes. -- 2003
C3017	Ependymoma	Ependymal_Tumor	Ependymoma|WHO Grade II Ependymal Neoplasm|WHO Grade II Ependymal Tumor|ependymoma	(ep-en-dih-MOE-mah) A type of brain tumor that may arise in the ventricles of the brain or in the spinal cord. Also called an ependymal tumor.
C3018	Sebaceous_Cyst	Skin_Cyst	Sebaceous Cyst
C3019	Epidural_Spinal_Canal_Neoplasm	Intraspinal_Neoplasm	Epidural Spinal Canal Neoplasm|Epidural Neoplasm|Epidural Spinal Canal Tumor|Epidural Spinal Canal Tumors|Epidural Spinal Neoplasms|Epidural Spinal Tumors|Epidural Tumor|Extradural Neoplasm|Extradural Spinal Canal Neoplasm|Extradural Spinal Canal Neoplasms|Extradural Spinal Canal Tumor|Extradural Spinal Neoplasms|Extradural Spinal Tumors|Extradural Tumor|Neoplasm of Epidural Spinal Canal|Neoplasm of Extradural Spinal Canal|Neoplasm of the Epidural Spinal Canal|Neoplasm of the Extradural Spinal Canal|Tumor of Epidural Spinal Canal|Tumor of Extradural Spinal Canal|Tumor of the Epidural Spinal Canal|Tumor of the Extradural Spinal Canal
C3020	Epilepsy	Non-Neoplastic_Central_Nervous_System_Disorder	Epilepsy|epilepsy	A group of disorders marked by problems in the normal functioning of the brain.  These problems can produce seizures, unusual body movements, a loss of consciousness or changes in consciousness, as well as mental problems or problems with the senses.
C3021	Generalized_Epilepsy	Epilepsy	Generalized Epilepsy
C3022	Grand_Mal_Epilepsy	Epilepsy	Grand Mal Epilepsy
C3023	Petit_Mal_Epilepsy	Epilepsy	Petit Mal Epilepsy
C3024	Erythema_Multiforme	Immune_System_Disorder	Erythema Multiforme
C3025	Erythroplakia	Oral_Cavity_and_Lip_Precancerous_Condition	Erythroplakia|erythroplakia	(eh-RITH-ro-PLAY-kee-a) A reddened patch with a velvety surface found in the mouth.
C3026	Esophageal_Cyst	Cyst|Gastrointestinal_System_Finding	Esophageal Cyst|Cyst of Esophagus|Cyst of the Esophagus|Esophagus Cyst
C3027	Esophageal_Disorder	Gastrointestinal_Disorder	Esophageal Disorder
C3028	Esophageal_Neoplasm	Esophageal_Disorder|Gastrointestinal_Neoplasm	Esophageal Neoplasm|Esophageal Neoplasms, Benign and Malignant|Esophageal Tumor|Esophageal Tumors|Esophagus Neoplasm|Esophagus Tumor|Neoplasm of Esophagus|Neoplasm of the Esophagus|Tumor of Esophagus|Tumor of the Esophagus	Abnormal growth of the cells of the esophagus, without specification as to whether the cells are benign or have malignant characteristics.
C3029	Exostosis	Non-Neoplastic_Bone_Disorder	Exostosis|Bone Spur
C3030	Eye_Neoplasm	Eye_Disorder|Neoplasm_by_Site	Eye Neoplasm|Eye Tumor|Neoplasm of Eye|Neoplasm of the Eye|Ocular Neoplasm|Ocular Tumor|Tumor of Eye|Tumor of the Eye	Abnormal growth of the cells that comprise the structures of the eye
C3031	Eyelid_Neoplasm	Eye_Neoplasm|Eyelid_Disorder	Eyelid Neoplasm|Eyelid Tumor|Neoplasm of Eyelid|Neoplasm of the Eyelid|Tumor of Eyelid|Tumor of the Eyelid
C3032	Fallopian_Tube_Neoplasm	Fallopian_Tube_Disorder|Female_Reproductive_System_Neoplasm	Fallopian Tube Neoplasm|Fallopian Tube Tumor|Neoplasm of Fallopian Tube|Neoplasm of the Fallopian Tube|Tumor of Fallopian Tube|Tumor of the Fallopian Tube
C3033	Familiar_Atypical_Multiple_Mole	Dysplastic_Nevus	Familiar Atypical Multiple Mole
C3034	Fanconi_Syndrome	DNA_Repair_Disorder|Hereditary_Neoplastic_Syndrome	Fanconi Anemia|De Toni-Debre-Fanconi Syndrome|Fanconi Syndrome|Fanconi's Anemia|Fanconi's anemia|Fanconi's syndrome|Lignac-Fanconi Syndrome|Pancytopenia, Congenital|Panmyelopathy, Fanconi|Primary Erythroid Hypoplasia|Short Limb Dwarfism-Saddle Nose-Spinal Alterations-Metaphyseal Striation Syndrome|Sponastrime|Spondylar and Nasal Alterations-Striated Metaphyses Syndrome	A rare and often fatal inherited disease in which the bone marrow fails to produce red blood cells, white blood cells, platelets, or a combination of these cells. The disease may transform into myelodysplastic syndrome or leukemia.
C3035	Fanconi_s_Anemia	Retired_Concepts	Fanconi's Anemia|Fanconi Anemia|Fanconi's anemia	A rare and often fatal inherited disease in which the bone marrow fails to produce red blood cells, white blood cells, platelets, or a combination of these cells. The disease may transform into myelodysplastic syndrome or leukemia.  Also called Fanconi's syndrome.
C3036	Fatigue	Mental_and_Behavioral_Signs_and_Symptoms	Fatigue|Lack of Energy	Fatigue is that state, following a period of mental or bodily activity, characterized by a lessened capacity for work and reduced efficiency of accomplishment, usually accompanied by a feeling of weariness, sleepiness, or irritability. (On-line Medical Dictionary)
C3037	Chronic_Fatigue_Syndrome	Immunodeficiency_Syndrome	Chronic Fatigue Syndrome	A syndrome of unknown etiology. Chronic fatigue syndrome (CFS) is a clinical diagnosis characterized by an unexplained persistent or relapsing chronic fatigue that is of at least six months' duration, is not the result of ongoing exertion, is not substantially alleviated by rest, and results in substantial reduction of previous levels of occupational, educational, social, or personal activities. Common concurrent symptoms of at least six months duration include impairment of memory or concentration, diffuse pain, sore throat, tender lymph nodes, headaches of a new type, pattern, or severity, and nonrestorative sleep. The etiology of CFS may be viral or immunologic. Neurasthenia and fibromyalgia may represent related disorders. Also known as myalgic encephalomyelitis. --2004
C3038	Fever	Body_Temperature_Associated_Symptom	Fever|FEB	The elevation of the body's temperature above the upper limit of normal, usually taken as 37.7 degrees C.
C3039	Breast_Fibrocystic_Change	Non-Neoplastic_Breast_Disorder	Breast Fibrocystic Change|Breast Fibrocystic Disease|Cystic Disease of Breast|Cystic Disease of the Breast|Diffuse Cystic Mastopathy|Fibrocystic Breast|Fibrocystic Breast Disease|Fibrocystic Change of Breast|Fibrocystic Change of the Breast|Fibrocystic Disease|Fibrocystic Disease of Breast|Fibrocystic Disease of the Breast|Fibrocystic Mastopathy	Fibrosis associated with cyst formation in the breast parenchyma. -- 2003
C3040	Fibrodysplasia_Ossificans_Progressiva	Benign_Extraskeletal_Cartilaginous_and_Osseous_Neoplasm	Fibrodysplasia Ossificans Progressiva|Myositis Ossificans Progressiva
C3041	Fibroma	Benign_Fibrous_Soft_Tissue_Neoplasm	Fibroma
C3042	Fibromatosis	Intermediate_Fibrocytic_Neoplasm	Fibromatosis|fibromatosis	A condition in which multiple fibromas develop.  Fibromas are tumors (usually benign) that affect connective tissue.
C3043	Fibrosarcoma	Fibrocytic_Neoplasm|Sarcoma_of_the_Soft_Tissue_and_Bone	Fibrosarcoma|fibrosarcoma	A malignant mesenchymal tumor composed of fibroblasts, and characterized by collagen production and a herringbone architectural pattern.  Fibrosarcomas are classified as adult or infantile.  Infantile fibrosarcomas generally have a much more favorable prognosis than adult fibrosarcomas. -- 2004
C3044	Fibrosis	Morphologic_Finding	Fibrosis|FIB|fibrosis	The growth of fibrous tissue.
C3045	Fistula	Congenital_or_Acquired_Anatomic_Abnormality	Fistula
C3046	Fracture	Bone_Injury	Fracture|FX	A traumatic injury to the bone in which the continuity of the bone is broken. - 2003
C3047	Pathologic_Fracture	Fracture	Pathologic Fracture|pathologic fracture	A broken bone caused by disease, often by the spread of cancer to the bone.
C3048	Gallbladder_Neoplasm	Gallbladder_Disorder|Hepato-Biliary_Neoplasm	Gallbladder Neoplasm|Gallbladder Tumor|Neoplasm of Gallbladder|Neoplasm of the Gallbladder|Tumor of Gallbladder|Tumor of the Gallbladder	Abnormal growth of the cells that comprise the gall bladder.
C3049	Ganglioneuroma	Autonomic_Nervous_System_Neoplasm|Neuroblastic_Tumor	Ganglioneuroma|Ganglioneuroma (Schwannian Stroma-Dominant)	A benign neuroblastic tumor of the sympathetic nervous system that occurs in childhood. Ganglioneuroma typically arises from the sympathetic trunk in the mediastinum. Histologic features include spindle cell proliferation (resembling a neurofibroma) and the presence of large ganglion cells. Common presenting features include a palpable abdominal mass, hepatomegaly, and a thoracic mass detected on routine chest X-ray. --2004
C3050	G-Cell_Gastrin_Producing_Neoplasm	Gastrointestinal_Neuroendocrine_Neoplasm	Gastrin Producing Tumor|G Cell Neoplasm|G Cell Tumor|G-Cell Gastrin Producing Neoplasm|G-Cell Gastrin Producing Tumor|G-Cell Neoplasm|G-Cell Tumor|Gastrin Producing Neoplasm|Gastrin Secreting Neoplasm|Gastrin Secreting Tumor|Gastrinoma|gastrinoma	(gas-tri-NO-ma) A tumor that causes overproduction of gastric acid.  It usually occurs in the islet cells of the pancreas but may also occur in the esophagus, stomach, spleen, or lymph nodes.
C3052	Gastrointestinal_Neoplasm	Gastrointestinal_Disorder|Neoplasm_by_Site	Gastrointestinal Neoplasm|Digestive Neoplasm|Digestive Tract Neoplasm|Digestive Tract Tumor|Digestive Tumor|GI Neoplasm|GI Tract Neoplasm|GI Tract Tumor|GI Tumor|Gastrointestinal Tract Neoplasm|Gastrointestinal Tract Tumor|Gastrointestinal Tumor|Neoplasm of Digestive Tract|Neoplasm of GI Tract|Neoplasm of Gastrointestinal Tract|Neoplasm of the Digestive Tract|Neoplasm of the GI Tract|Neoplasm of the Gastrointestinal Tract|Tumor of Digestive Tract|Tumor of GI Tract|Tumor of Gastrointestinal Tract|Tumor of the Digestive Tract|Tumor of the GI Tract|Tumor of the Gastrointestinal Tract	Abnormal growth in either the stomach or intestine
C3053	Female_Reproductive_System_Neoplasm	Female_Reproductive_System_Disorder|Reproductive_System_Neoplasm	Female Reproductive System Neoplasm|Female Reproductive System Tumor|Gynecologic Neoplasm|Gynecologic Tumor|Neoplasm of Female Reproductive System|Neoplasm of the Female Reproductive System|Tumor of Female Reproductive System|Tumor of the Female Reproductive System	Cancer in the human female's reproductive organs
C3054	Male_Reproductive_System_Neoplasm	Male_Reproductive_System_Disorder|Reproductive_System_Neoplasm	Male Reproductive System Neoplasm|Male Reproductive System Tumor|Neoplasm of Male Reproductive System|Neoplasm of the Male Reproductive System|Tumor of Male Reproductive System|Tumor of the Male Reproductive System	Abnormal growth of the tissues of the male reproductive tract: penis, scrotum and contents including testicles, prostate.
C3055	Giant_Cell_Tumor	Connective_and_Soft_Tissue_Neoplasm|Giant_Cell_Neoplasm	Giant Cell Tumor|Tumor of Giant Cell|Tumor of the Giant Cell
C3056	Angiofollicular_Lymphoid_Hyperplasia	Atypical_Lymphoproliferative_Disorder	Angiofollicular Lymphoid Hyperplasia|AFLH|Castleman's Disease|Castleman's Tumor|Castleman's disease|GLNH|Giant Lymph Node Hyperplasia	A rare disorder in which noncancerous growths develop in lymph node tissue.
C3057	Gingival_Neoplasm	Oral_Cavity_Neoplasm	Gingival Neoplasm|Gingival Tumor|Gum Neoplasm|Gum Tumor|Neoplasm of Gingiva|Neoplasm of Gum|Neoplasm of the Gingiva|Neoplasm of the Gum|Tumor of Gingiva|Tumor of Gum|Tumor of the Gingiva|Tumor of the Gum
C3058	Glioblastoma	Astrocytic_Tumor|Malignant_Glioma	Glioblastoma|GBM (Glioblastoma)|Glioblastoma Multiforme|Grade IV Astrocytic Neoplasm|Grade IV Astrocytic Tumor|Grade IV Astrocytoma|Spongioblastoma Multiforme|glioblastoma|glioblastoma multiforme|grade IV astrocytoma	(glee-o-blas-TOE-ma mul-tih-FOR-may) A type of brain tumor that forms from glial (supportive) tissue of the brain. It grows very quickly and has cells that look very different from normal cells.
C3059	Neuroglial_Tumor	Neuroepithelial_Neoplasm	Neuroglial Tumor|Glial Neoplasm|Glial Tumor|Glioma|Neoplasm of Neuroglia|Neoplasm of the Neuroglia|Neoplasms of Neuroglia|Neuroglial Neoplasm|Neuroglial Neoplasms|Tumor of Neuroglia|Tumor of the Neuroglia|Tumors of Neuroglia|glial tumors|glioma	(glee-O-ma) A cancer of the brain that begins in glial cells (cells that surround and support nerve cells).
C3060	Glomus_Tumor	Hemangiopericytic_Neoplasm	Glomus Tumor|Glomus Neoplasm
C3061	Jugulotympanic_Paraganglioma	Head_and_Neck_Paraganglioma|Parasympathetic_Paraganglioma	Jugulotympanic Paraganglioma|Glomus Jugulare Neoplasm|Glomus Jugulare Tumor|Jugular Paraganglioma|Neoplasm of Glomus Jugulare|Neoplasm of the Glomus Jugulare|Tumor of Glomus Jugulare|Tumor of the Glomus Jugulare	A benign or malignant extra-adrenal parasympathetic paraganglioma arising from paraganglia in the base of the skull and middle ear.
C3062	Pancreatic_Alpha_Cell_Glucagon_Producing_Neoplasm	Functioning_Pancreatic_Endocrine_Neoplasm	Pancreatic Glucagon Producing Tumor|Alpha Cell Neoplasm|Alpha Cell Neoplasm of Pancreas|Alpha Cell Neoplasm of the Pancreas|Alpha Cell Tumor|Alpha Cell Tumor of Pancreas|Alpha Cell Tumor of the Pancreas|Glucagon-Producing Islet Cell Neoplasm|Glucagon-Producing Islet Cell Tumor|Glucagon-Producing Neoplasm of Islet Cells|Glucagon-Producing Neoplasm of the Islet Cells|Glucagon-Producing Tumor of Islet Cells|Glucagon-Producing Tumor of the Islet Cells|Glucagonoma|Pancreatic Alpha Cell Neoplasm|Pancreatic Alpha Cell Tumor|Pancreatic Glucagon Producing Neoplasm|glucagonoma	(GLOO-kuh-guh-NO-ma) A rare pancreatic tumor that produces a hormone called glucagon. Glucagonomas can produce symptoms similar to diabetes.
C3063	Graft_Versus_Host_Disease	Cancer-Related_Condition|Transplant-Related_Disorder	Graft Versus Host Disease|GVHD|Graft Vs. Host Disease|Graft vs Host Disease|Graft-Versus-Host-Disease|Runt Disease|graft-versus-host disease	An incompatibility reaction (which may be fatal) in a subject (host) of low immunological competence (deficient lymphoid tissue) who has been the recipient of immunologically competent lymphoid tissue from a donor who lacks at least one antigen possessed by the recipient host; the reaction, or disease, is the result of action of the transplanted cells against those host tissues that possess the antigen not possessed by the donor. Seen most commonly following bone marrow transplantation, acute disease is seen after 5-40 days and chronic disease weeks to months after transplantation, affecting, principally, the gastrointestinal tract, liver, and skin.
C3064	Granuloma	Morphologic_Finding	Granuloma|Granulomatous Lesion
C3065	Granuloma_Inguinale	Infectious_Disorder	Granuloma Inguinale
C3066	Foreign_Body_Granuloma	Granuloma	Foreign Body Granuloma
C3067	Giant_Cell_Granuloma	Granuloma	Giant Cell Granuloma
C3068	Laryngeal_Granuloma	Granuloma_by_Site	Laryngeal Granuloma
C3069	Plasma_Cell_Granuloma	Granuloma	Plasma Cell Granuloma
C3070	Granulosa_Cell_Tumor	Sex_Cord-Stromal_Tumor	Granulosa Cell Tumor|Granulosa Cell Neoplasm|granulosa cell tumor	A slow-growing, malignant tumor, characterize by the presence of granulosa-like cells and Call-Exner bodies, that is almost always found in the ovary. In rare cases, it has also been found in the testicle.  There are two types of granulosa cell tumor that can be distinguished under the microscope: the adult and the juvenile.  The testicular juvenile granulosa cell tumors are perhaps the most common congenital testicular neoplasms. -- 2004
C3071	Graves_Disease	Goiter|Hyperthyroidism	Graves' Disease|Graves Disease	Hyperthyroidism associated with diffuse hyperplasia of the thyroid gland (goiter), resulting from production of antibodies that are directed against the thyrotropin receptor complex of the follicular epithelial cells.  As a result, the thyroid gland enlarges and secrets increased amounts of thyroid hormones. --2004
C3072	Gynandroblastoma	Ovarian_Sex_Cord-Stromal_Tumor_of_Mixed_or_Unclassified_Cell_Types	Ovarian Gynandroblastoma|Gynandroblastoma|Gynandroblastoma of Ovary|Gynandroblastoma of the Ovary
C3073	Gynecomastia	Benign_Male_Breast_Neoplasm	Gynecomastia	Excessive development of the breasts in males; usually the result of hormonal imbalance or treatment with certain drugs.
C3074	Hairy_Nevus	Pilosebaceous_Hamartoma	Hairy Nevus|Hair Nevus|Nevoid Hypertrichosis
C3075	Hamartoma	Diseases_and_Disorders	Hamartoma|hamartoma	(ham-ar-TOE-ma) A benign (noncancerous) growth made up of an abnormal mixture of cells and tissues normally found in the area of the body where the growth occurs.
C3076	Cowden_Syndrome	Hereditary_Neoplastic_Syndrome	Cowden Syndrome|Cowden's Disease|Multiple Hamartoma Syndrome	An autosomal dominant hereditary syndrome characterized by a variety of hamartomas and neoplasms including verrucous skin lesions, fibromas of the oral cavity, facial trichilemmomas, hamartomatous colonic polyps, thyroid neoplasms, breast cancer, and dysplastic gangliocytomas of the cerebellum. --2004
C3077	Head_and_Neck_Neoplasm	Head_and_Neck_Disorder|Neoplasm_by_Site	Head and Neck Neoplasm|Head and Neck Neoplasm (Excluding Central Nervous System)|Head and Neck Tumor|Neoplasm of Head and Neck|Neoplasm of the Head and Neck|Tumor of Head and Neck|Tumor of the Head and Neck	For oncology, area of the body generally construed to comprise base of skull and facial bones, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature and lymph nodes draining these areas.
C3078	Hearing_Disorder	Non-Neoplastic_Ear_Disorder	Hearing Disorder
C3079	Heart_Disease	Cardiovascular_Disorder|Thoracic_Disorder	Heart Disorder|Heart Disease
C3080	Congestive_Heart_Failure	Non-Neoplastic_Heart_Disorder	Congestive Heart Failure|Cardiac Failure Congestive|congestive heart failure	1. inadequacy of the heart so that as a pump it fails to maintain the circulation of blood, with the result that congestion and edema develop in the tissues; SEE ALSO forward heart failure, backward heart failure, right ventricular failure, left ventricular failure. SYN cardiac failure, cardiac insufficiency, congestive heart failure, myocardial insufficiency. 2. resulting clinical syndromes including shortness of breath, pitting edema, enlarged tender liver, engorged neck veins, and pulmonary rales in various combinations.
C3081	Cardiac_Neoplasm	Cardiovascular_Neoplasm|Heart_Disease|Thoracic_Neoplasm	Cardiac Neoplasm|Cardiac Neoplasms|Cardiac Tumor|Heart Neoplasm|Heart Tumor|Neoplasm of Heart|Neoplasm of the Heart|Tumor of Heart|Tumor of the Heart	Abnormal growth of the cells comprising the cardiac muscle, valves, and/or vessels
C3082	Heavy_Chain_Disease	Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Heavy Chain Disease	One of a group of rare disorders of immunoglobulin synthesis associated with B-cell proliferative disorders and diagnosed by the finding of heavy chains in the serum, urine, or both. Heavy chains are immunologically related to the Fc fragment of the immunoglobulin chain. Three types of heavy chain disease (HCD) have been recognized: gamma heavy chain disease (associated with Waldenstrom's macroglobulinemia), alpha heavy chain disease (also known as immunoproliferative small intestinal disease or Mediterranean lymphoma), and mu heavy chain disease (associated with chronic lymphocytic leukemia). Complications of HCD vary depending upon type. Also known as paraproteinemia. --2004
C3083	Gamma_Heavy_Chain_Disease	Heavy_Chain_Disease	Gamma Heavy Chain Disease|Franklin Disease|Franklin's Disease	A clonal disorder characterized by the secretion of a truncated gamma chain.  In most cases, it is associated with morphologic changes also seen in lymphoplasmacytic lymphomas, but the clinical course is typically more aggressive than in lymphoplasmacytic lymphoma/Waldenstrom's macroglobulinemia. --2004
C3084	Hemangioendothelioma	Blood_Vessel_Neoplasm	Hemangioendothelioma|Angioendothelioma
C3085	Hemangioma	Benign_Blood_Vessel_Neoplasm	Hemangioma|Angioma|Benign Angioma|Benign Hemangioma	benign tumor made up of newly formed blood vessels.
C3086	Cavernous_Hemangioma	Hemangioma	Cavernous Hemangioma|Cavernoma|Cavernous Angioma
C3087	Hemangiopericytoma	Hemangiopericytic_Neoplasm	Hemangiopericytoma|hemangiopericytoma	A mesenchymal tumor of perivascular cell origin, composed of dilated vascular spaces (some with a staghorn or bifed shape) throughout the entire tumor.  The tumor cells are surrounded by reticulin, are negative for muscle, nerve sheath, and epithelial markers, and are positive for CD34.  The biologic behavior of hemangiopericytoma cannot always be predicted from the morphologic features.  The 5- and 10-year survival rates of malignant hemangiopericytomas have been reported to be 40% and 29% respectively (partially adapted from S. Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999). -- 2004
C3088	Angiosarcoma	Malignant_Blood_Vessel_Neoplasm|Sarcoma_of_the_Soft_Tissue_and_Bone	Angiosarcoma|Hemangiosarcoma|angiosarcoma	(AN-jee-o-sar-KO-ma) A type of cancer that begins in the lining of blood vessels.
C3090	Hematuria	Genitourinary_Signs_and_Symptoms	Hematuria|HEMTR	A condition in which free hemoglobin is found in the urine. --2004
C3092	Hemoglobinopathy	Non-Neoplastic_Hematologic_Disorder	Hemoglobinopathy|Hemoglobinopathies / Iron Metabolism
C3093	Hemophilia	Coagulation_Factor_Deficiency	Hemophilia|hemophilia	A deficiency or abnormality of a blood coagulation factor characterized by the tendency to spontaneous or exaggerated post-traumatic hemorrhage, Hemophilia is typically a hereditary disorder but, rarely, may be acquired. Inherited coagulation factor-deficient hemophilias include hemophilia A or classic hemophilia (Factor VIII deficiency) hemophilia B or Christmas disease (Factor IX deficiency), and hemophilia C (Factor XI deficiency). In individuals without hereditary hemophilia A, Factor VIII inhibitors may occur spontaneously as autoantibodies, resulting in a condition known as 'acquired hemophilia.' Approximately 10 % of patients with acquired hemophilia have an underlying malignancy. --2004
C3094	Hemoptysis	Symptom	Hemoptysis|HEMPY	Coughing up blood from the respiratory tract.
C3095	Hepatitis	Hepatocellular_Damage|Non-Neoplastic_Gastrointestinal_Disorder	Hepatitis|hepatitis	(hep-a-TYE-tis) Disease of the liver causing inflammation.  Symptoms include an enlarged liver, fever, nausea, vomiting, abdominal pain, and dark urine.
C3096	Hepatitis_A	Acute_Hepatitis|Viral_Hepatitis	Hepatitis A
C3097	Hepatitis_B	Viral_Hepatitis	Hepatitis B|Hepatitis B Infection|Viral Hepatitis B	A viral hepatitis caused by the Hepatitis B virus.
C3098	Hepatitis_C	Viral_Hepatitis	Hepatitis C|NANBH|Non-A, Non-B Hepatitis|hepatitis C	A viral hepatitis caused by the Hepatitis C virus.
C3099	Hepatocellular_Carcinoma	Adenocarcinoma|Common_Carcinoma|Hepatic_Disorder|Liver_and_Intrahepatic_Biliary_Tract_Carcinoma	Hepatocellular Carcinoma|Carcinoma of Liver Cells|Carcinoma of the Liver Cells|HCC|Hepatoma|Liver Cell Carcinoma|Primary Carcinoma of Liver Cells|Primary Carcinoma of the Liver Cells|hepatocellular carcinoma|hepatoma	(HEP-a-toe-SEL-yoo-ler kar-sin-O-ma) A type of adenocarcinoma, the most common type of liver tumor.
C3100	Hepatomegaly	Gastrointestinal_System_Signs_and_Symptoms	Hepatomegaly|HEPMG	Abnormal enlargement of the liver.
C3101	Genetic_Disorder	Diseases_and_Disorders	Genetic Disorder|Genetic Condition|Hereditary Diseases|Molecular Disease	Genetic Diseases are diseases in which inherited genes predispose to increased risk.  The genetic disorders associated with cancer often result from an alteration or mutation in a single gene.  The diseases range from rare dominant cancer family syndrome to familial tendencies in which low-penetrance genes may interact with other genes or environmental factors to induce cancer.  Research may involve clinical, epidemiologic, and laboratory studies of persons, families, and populations at high risk of these disorders.
C3105	Von_Hippel-Lindau_Syndrome	Hereditary_Neoplastic_Syndrome	Von Hippel-Lindau Syndrome|Cerebroretinal Angiomatosis|Von Hippel-Lindau Disease|Von Hippel-Lindau Syndrome (VHL)|von Hippel-Lindau syndrome	A rare inherited disorder in which blood vessels grow abnormally in the eyes, brain, spinal cord, adrenal glands, or other parts of the body. People with von Hippel-Lindau syndrome have a higher risk of developing some types of cancer.
C3106	Histiocytosis	Morphologic_Finding	Histiocytic Infiltrate|Histiocytosis
C3107	Langerhans_Cell_Histiocytosis	Histiocytic_and_Dendritic_Cell_Neoplasms	Langerhans Cell Histiocytosis|Histiocytosis X|Langerhans Cell Granulomatosis	A neoplastic proliferation of Langerhans cells which contain Birbeck granules by ultrastructural examination.  Three major overlapping syndromes are recognized: eosinophilic granuloma, Letterer-Siwe disease, and Hand-Schuller-Christian disease.  The clinical course is generally related to the number of organs affected at presentation.  (WHO, 2001) -- 2003
C3108	HIV_Infection	Viral_Infection	HIV Infection	any state accompanied by evidence of HIV in the body (positive test for HIV genome, cDNA, proteins, antigens, or antibodies); may be medically asymptomatic or symptomatic; prefer AIDS when appropriate.
C3109	Hot_Flashes	Body_Temperature_Associated_Symptom	Hot Flashes|Hot Flash|hot flash	A sudden, temporary onset of body warmth, flushing, and sweating (often associated with menopause).
C3110	Hydatidiform_Mole	Common_Germ_Cell_Neoplasm|Gestational_Trophoblastic_Tumor	Hydatidiform Mole|Hydatid Mole|Molar Pregnancy|molar pregnancy	A gestational disorder characterized by an abnormal placenta with marked enlargement of the chorionic villi and hyperplasia of the villous trophoblastic cells.  According to the amount of villous involvement, a hydatidiform mole is defined as complete or partial.  Most molar pregnancies are complete and are characterized by generalized hydropic villous changes.  Partial moles are characterized by a mixture of large hydropic villi and normal placenta tissue.  Complete moles are usually diploid and typically present between the eleventh and twenty-fifth week of pregnancy, whereas partial moles are usually triploid and usually present around the nineteenth week of pregnancy.  The incidence of choriocarcinoma is higher in patients with complete hydatidiform mole.  When a hydatidiform mole invades the myometrium and broad ligament, or it is found in distant sites as vagina, vulva, and lung, it is referred as invasive mole. --2004
C3111	Hydrocephalus	Central_Nervous_System_Disorder	Hydrocephalus|hydrocephalus	(hye-dro-SEF-uh-lus) The abnormal buildup of cerebrospinal fluid in the ventricles of the brain.
C3112	Hypercalcemia	Abnormal_Blood_and_Hematology_Test_Result	Hypercalcemia|hypercalcemia	(hye-per-kal-SEE-mee-a) Abnormally high blood calcium.
C3113	Hyperplasia	Diseases_and_Disorders	Hyperplasia|Hyperplastic|hyperplasia	(hye-per-PLAY-zha) An abnormal increase in the number of cells in an organ or tissue.
C3114	Hypersensitivity	Immune_System_Disorder	Hypersensitivity|Allergy|hypersensitivity	An exaggerated response by the immune system to a drug or other substance.
C3115	Delayed-Type_Hypersensitivity	Hypersensitivity	Delayed-Type Hypersensitivity|Delayed-Type Hypersensitivity Response|delayed-type hypersensitivity response	DTH. An inflammatory response that develops 24 to 72 hours after exposure to an antigen that the immune system recognizes as foreign.  This type of immune response involves mainly T cells rather than antibodies (which are made by B cells).
C3116	Immediate_Hypersensitivity	Hypersensitivity	Immediate Hypersensitivity	Immediate hypersensitivity reaction - type I reaction, involves immunoglobulin E (IgE)-mediated release of chemical mediators from mast cells and basophils. Th2 cells produce IL-4 and IL-13, which then act on B cells to promote the production of antigen-specific IgE. Reexposure to the antigen can then result in the antigen binding to and cross-linking the bound IgE antibodies on the mast cells and basophils. This causes the release of preformed mediators (histamine, tryptase, tryptase, chemotactic factors), newly synthesized mediators (leukotrienes, prostaglandin, thromboxane, platelet-activating factor, adenosine, bradykinin), and cytokines from these cells that results in structural and functional changes to the affected tissue.
C3117	Hypertension	Cardiovascular_System_Finding	Hypertension|HTN|Vascular Hypertensive Disorder|hypertension	Abnormally high blood pressure.
C3118	Malignant_Hypertension	Hypertension	Malignant Hypertension
C3119	Portal_Hypertension	Hypertension	Portal Hypertension	abnormally increased pressure in the portal venous system, frequently seen in cirrhosis of the liver and other conditions causing obstruction of the portal vein.
C3120	Pulmonary_Hypertension	Hypertension	Pulmonary Hypertension	increased pressure with the the pulmonary circulation, usually secondary to cardiac or pulmonary disease.
C3121	Renal_Hypertension	Hypertension	Renal Hypertension	hypertension due to renal disease.
C3122	Hypertensive_Crisis	Hypertensive_Episode	Hypertensive Crisis
C3123	Hyperthyroidism	Non-Neoplastic_Endocrine_Disorder|Non-Neoplastic_Thyroid_Gland_Disorder	Hyperthyroidism|Overactive Thyroid|hyperthyroidism|overactive thyroid	Too much thyroid hormone. Symptoms include weight loss, chest pain, cramps, diarrhea, and nervousness.
C3124	Hypertrophy	Morphologic_Finding	Hypertrophy|HTRPY	Abnormal enlargement of a body part or organ.
C3125	Hypertrophy_of_the_Breast	Non-Neoplastic_Breast_Disorder	Breast Hypertrophy|Hypertrophy of Breast|Hypertrophy of the Breast
C3126	Hypoglycemia	Abnormal_Blood_and_Hematology_Test_Result	Hypoglycemia|hypoglycemia	Abnormally low blood sugar.
C3127	Hypopharyngeal_Neoplasm	Pharyngeal_Neoplasm	Hypopharyngeal Neoplasm|Hypopharyngeal Neoplasms|Hypopharyngeal Tumor|Neoplasm of Hypopharynx|Neoplasm of the Hypopharynx|Tumor of Hypopharynx|Tumor of the Hypopharynx
C3128	Hypotension	Cardiovascular_System_Finding	Hypotension|Vascular Hypotensive Disorder|hypotension	Abnormally low blood pressure.
C3129	Hypothalamic_Neoplasm	Diencephalic_Neoplasm	Hypothalamic Neoplasm|Hypothalamic Neoplasms|Hypothalamic Tumor|Neoplasm of Hypothalamus|Neoplasm of the Hypothalamus|Tumor of Hypothalamus|Tumor of the Hypothalamus
C3130	Ileal_Neoplasm	Small_Intestinal_Neoplasm	Ileal Neoplasm|Ileal Tumor|Neoplasm of Ileum|Neoplasm of the Ileum|Tumor of Ileum|Tumor of the Ileum
C3131	Immunodeficiency_Syndrome	Immune_System_Disorder|Syndrome	Immunodeficiency Syndrome|Immunodeficiency Disorder|immunodeficiency|immunodeficiency syndrome	Syndromes in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral.
C3132	Alpha_Heavy_Chain_Disease	Heavy_Chain_Disease	Alpha Heavy Chain Disease|IPSID|Immunoproliferative Small Intestinal Disease|Mediterranean Abdominal Lymphoma	A clonal disorder, also known as immunoproliferative small intestinal disease or Mediterranean lymphoma, characterised by the secretion of a defective alpha heavy chain.  It predominantly affects young people in the Mediterranean region.  It involves the small intestine, and patients usually present with malabsorption syndrome, abdominal pain, weight loss, and fever.  There is extensive villous atrophy of the small intestinal mucosa, which is heavily infiltrated by small lymphocytes and plasma cells.  The small intestinal morphologic changes are consistent with a mucosa-associated lymphoid tissue lymphoma (MALT lymphoma).  Alpha heavy chain disease frequently progresses to large B-cell lymphoma, and normally has a poor prognosis. -- 2004
C3133	Impotence	Sexual_Dysfunction	Impotence|Erectile Dysfunction|Impotent|impotent	(IM-po-tent) Unable to have an erection adequate for sexual intercourse.
C3134	Epidermal_Inclusion_Cyst	Skin_Cyst	Epidermal Inclusion Cyst|Epidermal Cyst|Epidermoid Cyst|Epithelial Cyst|Horn Cyst|Inclusion Cyst|Keratin Cyst|Keratinizing Cyst|Keratinous Cyst
C3137	Inflammation	Other_Finding	Inflammation|INFLM|inflammation	A localized protective response resulting from injury or destruction of tissues. Inflammation serves to destroy, dilute, or wall off both the injurious agent and the injured tissue. In the acute phase, inflammation is characterized by the signs of pain, heat, redness, swelling, and loss of function. Histologically, inflammation involves a complex series of events, including dilatation of arterioles, capillaries, and venules, with increased permeability and blood flow; exudation of fluids, including plasma proteins; and leukocyte migration into the site of inflammation. --2004
C3138	Inflammatory_Bowel_Disease	Enteritis|Intestinal_Precancerous_Condition	Inflammatory Bowel Disease|IBD|inflammatory bowel disease	A general term that refers to the inflammation of the colon and rectum. Inflammatory bowel disease includes ulcerative colitis and Crohn's disease.
C3139	Infratentorial_Neoplasm	Brain_Neoplasm	Infratentorial Neoplasm|Brain Neoplasms, Infratentorial|Infratentorial Neoplasms|Infratentorial Tumor|Infratentorial Tumors|Neoplasms, Infratentorial	Benign and malignant neoplasms which occur in brain parenchymal tissue below the tentorium cerebelli.  This primarily refers to neoplasms within the brainstem and/or cerebellum.
C3140	Pancreatic_Beta_Cell_Insulin_Producing_Neoplasm	Functioning_Pancreatic_Endocrine_Neoplasm	Pancreatic Insulin Producing Tumor|Beta Cell Neoplasm|Beta Cell Neoplasm of Pancreas|Beta Cell Neoplasm of the Pancreas|Beta Cell Tumor|Beta Cell Tumor of Pancreas|Beta Cell Tumor of the Pancreas|Insulin-Producing Islet Cell Neoplasm|Insulin-Producing Islet Cell Tumor|Insulin-Producing Neoplasm of Islet Cells|Insulin-Producing Neoplasm of the Islet Cells|Insulin-Producing Tumor of Islet Cells|Insulin-Producing Tumor of the Islet Cells|Insulinoma|Pancreatic Beta Cell Tumor|Pancreatic Insulin Producing Neoplasm	A usually benign, well circumscribed neoplasm arising from the beta cells of the pancreas.  Patients exhibit symptoms related to hypoglycemia due to inappropriate secretion of insulin.
C3141	Intestinal_Neoplasm	Gastrointestinal_Neoplasm|Intestinal_Disorder	Intestinal Neoplasm|Intestinal Neoplasms|Intestinal Tumor|Intestinal Tumors|Neoplasm of Intestines|Neoplasm of the Intestines|Tumor of Intestines|Tumor of the Intestines	Abnormal growth of the cells of the intestinal tissues.
C3142	Iris_Neoplasm	Iris_Disorder|Uveal_Neoplasm	Iris Neoplasm|Iris Tumor|Neoplasm of Iris|Neoplasm of the Iris|Tumor of Iris|Tumor of the Iris
C3143	Jaundice	Gastrointestinal_System_Signs_and_Symptoms	Jaundice|jaundice	(JAWN-dis) A condition in which the skin and the whites of the eyes become yellow, urine darkens, and the color of stool becomes lighter than normal. Jaundice occurs when the liver is not working properly or when a bile duct is blocked.
C3144	Hyperimmunoglobulin_E_Syndrome	Hyperimmunoglobulin_Syndrome	Hyperimmunoglobulin E Syndrome
C3145	Keloid	Reactive_Cutaneous_Fibrous_Lesions	Keloid|keloid	(KEY-loyd) A thick, irregular scar caused by excessive tissue growth at the site of an incision or wound.
C3146	Keratoacanthoma	Skin_Squamous_Cell_Carcinoma	Keratoacanthoma|keratoacanthoma	(KER-a-toe-AK-an-THOW-ma) A benign (noncancerous), rapidly growing skin tumor that usually occurs on sun-exposed areas of the skin and that can go away without treatment.
C3147	Diffuse_Palmoplantar_Keratoderma	Cutaneous_Precancerous_Condition|Palmoplantar_Keratoderma	Diffuse Palmoplantar Keratoderma|Keratosis Palmaris et Plantaris|Tylosis|Unna-Thost Disease
C3148	Actinic_Solar_Keratosis	Pre-Malignant_Skin_Epithelial_Lesions	Actinic (Solar) Keratosis|Actinic Keratosis|Senile Hyperkeratosis|Senile Keratosis|Solar Keratosis|actinic keratosis|senile keratosis|solar keratosis	(ak-TIN-ik ker-a-TOE-sis) A precancerous condition of thick, scaly patches of skin.
C3149	Renal_Disorder	Urinary_Tract_Disorder	Renal Disorder|Kidney Disease|Kidney Disorder|Renal Disease
C3150	Renal_Neoplasm	Kidney_and_Ureter_Neoplasm|Renal_Disorder	Renal Neoplasm|Kidney Neoplasm|Kidney Tumor|Neoplasm of Kidney|Neoplasm of the Kidney|Renal Tumor|Renal Tumors|Tumor of Kidney|Tumor of the Kidney	Abnormal growth of tissues of the kidney
C3151	Penile_Leukoplakia	Genital_Leukoplakia	Penile Leukoplakia|Kraurosis Penis|Leukoplakia of Penis|Leukoplakia of the Penis
C3152	Vulval_Leukoplakia	Genital_Leukoplakia	Vulval Leukoplakia|Breisky's Disease|Kraurosis Vulvae|Leucoplakia of Vulva
C3153	Krukenberg_Tumor	Metastatic_Adenocarcinoma|Metastatic_Malignant_Neoplasm_to_the_Ovary|Signet_Ring_Cell_Carcinoma	Krukenberg Tumor|Krukenberg Neoplasm|Krukenberg tumor	(KROO-ken-berg TOO-mer) A tumor in the ovary caused by the spread of stomach cancer.
C3154	Lactose_Intolerance	Malabsorption_Syndrome|Non-Neoplastic_Gastrointestinal_Disorder	Lactose Intolerance|lactose intolerance	The inability to digest or absorb lactose, a type of sugar found in milk and other dairy products.
C3155	Lambert_Eaton_Myasthenic_Syndrome	Paraneoplastic_Syndrome	Lambert Eaton Myasthenic Syndrome
C3156	Laryngeal_Neoplasm	Laryngeal_Disorder|Neck_Neoplasm	Laryngeal Neoplasm|Laryngeal Tumor|Larynx Neoplasm|Larynx Tumor|Neoplasm of Larynx|Neoplasm of the Larynx|Tumor of Larynx|Tumor of the Larynx	(lair-IN-jee-al) Having to do with the larynx.
C3157	Leiomyoma	Benign_Smooth_Muscle_Neoplasm|Common_Connective_and_Soft_Tissue_Neoplasm	Leiomyoma|Fibroid|Fibroid Neoplasm|Fibroid Tumor|Leiomyomatous Neoplasm|Leiomyomatous Tumor|fibroid|leiomyoma	(FYE-broyd) A benign smooth-muscle tumor, usually in the uterus or gastrointestinal tract.
C3158	Leiomyosarcoma	Malignant_Smooth_Muscle_Neoplasm|Sarcoma_of_the_Soft_Tissue_and_Bone	Leiomyosarcoma|Leiomyosarcomas|leiomyosarcoma	A common malignant mesenchymal neoplasm.  It originates from the smooth muscles, and the most common anatomic sites are the uterus and the gastrointestinal tract.  It is characterized by spindle cell morphology.  Cellular pleomorphism may be present. -- 2003
C3159	Lentigo	Non-Neoplastic_Skin_Disorder	Lentigo|Lentiginosis
C3160	Letterer-Siwe_Disease	Langerhans_Cell_Histiocytosis	Letterer-Siwe Disease
C3161	Leukemia	Hematopoietic_Cell_Neoplasm	Leukemia|Blood (Leukemia)|LEUK|Leukemias|Leukemias, General|leukemia	(loo-KEE-mee-a) Cancer of blood-forming tissue.
C3162	B-Cell_Leukemia	Leukemia_Antiquated	B-Cell Leukemia|B-Lymphocytic Leukemia
C3163	Chronic_Lymphocytic_Leukemia	Chronic_Leukemia|Chronic_Lymphocytic_Leukemia_Small_Lymphocytic_Lymphoma|Common_Hematopoietic_Neoplasm|Lymphoid_Leukemia	Chronic Lymphocytic Leukemia|B Cell CLL|B Cell Chronic Lymphocytic Leukemia|B Cell Lymphocytic Leukemia|B-Cell CLL|B-Cell Chronic Lymphocytic Leukemia|B-Cell Chronic Lymphogenous Leukemia|B-Cell Chronic Lymphoid Leukemia|B-Cell Lymphocytic Leukemia|CLL|Chronic B-Cell Lymphocytic Leukemia|Chronic Lymphatic Leukemia|Chronic Lymphogenous Leukemia|chronic lymphocytic leukemia	A slowly progressing disease in which too many white blood cells (called lymphocytes) are found in the body.
C3164	Acute_Basophilic_Leukemia	Acute_Myeloid_Leukemia_not_Otherwise_Categorized	Acute Basophilic Leukemia|Basophilic Leukemia|Leukemia Basophilic	An acute myeloid leukemia in which the immature cells differentiate towards basophils.  This is a rare leukemia.  The observed cases have been associated with a poor prognosis.  The term basophilic leukemia is used as a synonym for acute basophilic leukemia.  Chronic basophilic leukemia is an inappropriate term vaguely connected to the term mast cell leukemia.  (WHO, 2001) -- 2003
C3165	cALLa_Positive_Lymphoblastic_Leukemia	Leukemia_Antiquated	cALLa Positive Lymphoblastic Leukemia
C3167	Acute_Lymphoblastic_Leukemia	Acute_Leukemia|Lymphoid_Leukemia|Precursor_Lymphoblastic_Leukemia_Lymphoma	Precursor Lymphoblastic Leukemia|ALL|ALL - Acute Lymphocytic Leukemia|Acute Lymphoblastic Leukemia|Acute Lymphocytic Leukaemia|Acute Lymphocytic Leukemia|Acute Lymphocytic Leukemias|Acute Lymphogenous Leukemia|Acute Lymphoid Leukemia|Lymphoblastic Leukemia|Precursor Cell Lymphoblastic Leukemia|acute lymphoblastic leukemia|acute lymphocytic leukemia	A quickly progressing disease in which too many immature white blood cells called lymphoblasts are found in the blood and bone marrow.
C3168	Childhood_Acute_Lymphoblastic_Leukemia	Acute_Lymphoblastic_Leukemia|Childhood_Leukemia	Childhood Acute Lymphoblastic Leukemia|Childhood ALL|Childhood Acute Lymphocytic Leukemia|Childhood Acute Lymphogenous Leukemia|Childhood Acute Lymphoid Leukemia|Pediatric ALL|Pediatric Acute Lymphoblastic Leukemia|Pediatric Acute Lymphocytic Leukemia|Pediatric Acute Lymphogenous Leukemia|Pediatric Acute Lymphoid Leukemia	A heterogeneous disorder characterized by an uncontrolled proliferation and conspicuous enlargement of lymphoid tissue and the occurrence of increased numbers of cells in the lymphatic system circulating in the blood, occurring in children. (from DCTD)
C3169	Mast_Cell_Leukemia	Leukemia|Malignant_Mastocytosis|Primary_Systemic_Mastocytosis	Mast Cell Leukemia	A variant of systemic mastocytosis with involvement of the bone marrow (20% or more mast cells) and the peripheral blood (mast cells account for 10% or more of peripheral blood white cells). (WHO, 2001) -- 2003
C3170	Acute_Megakaryoblastic_Leukemia	Acute_Myeloid_Leukemia_not_Otherwise_Categorized|Megakaryocytic_Neoplasm	Acute Megakaryoblastic Leukemia|Acute M7 Myeloid Leukemia|Acute Megakaryoblastic Leukemia (FAB Type M7)|Acute Megakaryocytic Leukemia|FAB M7	An acute myeloid leukemia in which at least 50% of the blasts are of megakaryocytic lineage.  The prognosis is usually poor.  (WHO, 2001) -- 2003
C3171	Acute_Myeloid_Leukemia	Acute_Leukemia|Common_Hematopoietic_Neoplasm|Myeloid_Leukemia	Acute Myeloid Leukemia|AML|AML - Acute Myeloid Leukemia|ANLL|Acute Myeloblastic Leukemia|Acute Myelocytic Leukemia|Acute Myelogenous Leukemia|Acute Myelogenous Leukemias|Acute Nonlymphocytic Leukemia|acute myelogenous leukemia|acute myeloid leukemia|acute nonlymphocytic leukemia	A clonal expansion of myeloid blasts in the bone marrow, blood or other tissues.  The classification of acute myeloid leukemias (AMLs) encompasses four major categories: 1) AML with recurrent genetic abnormalities 2) AML with multilineage dysplasia 3) Therapy-related AML 4) AML not otherwise categorized.  The required bone marrow or peripheral blood blast percentage for the diagnosis of AML has been recently reduced from 30% (French-American-British [FAB] classification) to 20% (WHO classification).  (WHO, 2001) -- 2003
C3172	Myeloid_Leukemia	Leukemia|Myeloid_Neoplasm	Myeloid Leukemia|Myelocytic Leukemia|Myelogenous Leukemia|Non-Lymphoblastic Leukemia|Non-Lymphocytic Leukemia	leukemia characterized by an uncontrolled proliferation of the myeloid lineage and their precursors in the bone marrow and other sites.
C3173	Accelerated_Phase_Chronic_Myelogenous_Leukemia	Chronic_Myelogenous_Leukemia	Accelerated Phase Chronic Myelogenous Leukemia|Accelerated Phase CML|Accelerated Phase Chronic Granulocytic Leukemia|Accelerated Phase Chronic Myelocytic Leukemia|Accelerated Phase Chronic Myeloid Leukemia|Aggressive-Phase CML|Aggressive-Phase Chronic Myelocytic Leukemia|Aggressive-Phase Chronic Myelogenous Leukemia|Aggressive-Phase Chronic Myeloid Leukemia
C3174	Chronic_Myelogenous_Leukemia	Chronic_Myeloproliferative_Disorder|Common_Hematopoietic_Neoplasm|Myeloid_Leukemia	Chronic Myelogenous Leukemia|CML|CML - Chronic Myelogenous Leukemia|Chronic Granulocytic Leukemia|Chronic Myelocytic Leukemia|Chronic Myelogenous Leukemias|Chronic Myeloid Leukemia|chronic granulocytic leukemia|chronic myelogenous leukemia|chronic myeloid leukemia	A slowly progressing disease in which too many white blood cells are made in the bone marrow.
C3175	Chronic_Phase_Chronic_Myelogenous_Leukemia	Chronic_Leukemia|Chronic_Myelogenous_Leukemia	Chronic Phase Chronic Myelogenous Leukemia|Chronic Phase CML|Chronic Phase Chronic Granulocytic Leukemia|Chronic Phase Chronic Myelocytic Leukemia|Chronic Phase Chronic Myeloid Leukemia|chronic phase chronic myelogenous leukemia	A phase of chronic myelogenous leukemia that may last from several months to several years. Although there may be no symptoms of leukemia, there are too many white blood cells.
C3176	Philadelphia-Negative_Myelogenous_Leukemia	Myeloid_Leukemia	Philadelphia-Negative Myelogenous Leukemia
C3177	Philadelphia-Positive_Myelogenous_Leukemia	Myeloid_Leukemia	Philadelphia-Positive Myelogenous Leukemia|Ph1-Positive Granulocytic Leukemia|Ph1-Positive Myelocytic Leukemia|Ph1-Positive Myelogenous Leukemia|Ph1-Positive Myeloid Leukemia|Philadelphia-Positive Granulocytic Leukemia|Philadelphia-Positive Myelocytic Leukemia|Philadelphia-Positive Myeloid Leukemia
C3178	Chronic_Myelomonocytic_Leukemia	Myelodysplastic_Myeloproliferative_Disease	Chronic Myelomonocytic Leukemia|CMML	A myelodysplastic/myeloproliferative disease which is characterized by persistent monocytosis, absence of a Philadelphia chromosome and BCR/ABL fusion gene, fewer than 20% blasts in the bone marrow or blood, and myelodysplasia.  (WHO, 2001) -- 2003
C3179	Chronic_Neutrophilic_Leukemia	Chronic_Leukemia|Chronic_Myeloproliferative_Disorder	Chronic Neutrophilic Leukemia|Neutrophilic Leukemia	A rare chronic myeloproliferative disorder characterised by neutrophilic leukocytosis.  There is no detectable Philadelphia chromosome or BCR/ABL fusion gene.  -- 2003
C3180	Plasma_Cell_Leukemia	Lymphoid_Leukemia|Plasma_Cell_Neoplasm	Plasma Cell Leukemia|Leukemia Plasmacytic|Plasmacytic Leukemia	rare type of acute leukemia in which the predominating cell in the peripheral blood is the plasma cell; it is often seen in conjunction with multiple myeloma and may be a variant form of that disease.
C3181	Prolymphocytic_Leukemia	Chronic_Leukemia|Lymphoid_Leukemia	Prolymphocytic Leukemia|prolymphocytic leukemia	PLL. A type of chronic lymphocyctic leukemia (CLL), in which too many immature white blood cells (prolymphocytes) are found in the blood and bone marrow. PLL usually progresses more rapidly than classic CLL.
C3182	Acute_Promyelocytic_Leukemia	Acute_Myeloid_Leukemia_with_Recurrent_Genetic_Abnormalities	Acute Promyelocytic Leukemia|APL|APML|APML - Acute promyelocytic leukemia|FAB M3|Promyelocytic Leukemia|promyelocytic leukemia	A type of acute myeloid leukemia, a quickly progressing disease in which too many immature blood-forming cells are found in the blood and bone marrow.
C3183	Precursor_T_Lymphoblastic_Leukemia	Acute_Lymphoblastic_Leukemia|Common_Hematopoietic_Neoplasm|Precursor_T_Lymphoblastic_Leukemia_Lymphoma	Precursor T-Lymphoblastic Leukemia|Acute T Cell Leukemia|Acute T Cell Lymphoblastic Leukemia|Acute T Cell Lymphocytic Leukemia|Acute T-Cell Leukemia|Acute T-Cell Lymphoblastic Leukemia|Acute T-Cell Lymphocytic Leukemia|T-ALL|T-Cell Acute Lymphoblastic Leukemia|T-Cell Type Acute Leukemia	This type of acute lymphoblastic leukemia comprises about 15% of childhood cases and 25% of adult cases.  It is more common in males than females.  (WHO, 2001) -- 2003
C3184	Adult_T-Cell_Lymphoma_Leukemia	Aggressive_Adult_Non-Hodgkin_s_Lymphoma|HTLV-1-Related_Malignant_Neoplasm|Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma|Virus-Related_Lymphoma	Adult T-Cell Lymphoma/Leukemia|ATLL|Adult T Cell Lymphoma/Leukemia|HTLV-1 Associated Adult T-Cell Lymphoma/Leukemia|HTLV-I Associated Adult T-Cell Leukemia/Lymphoma|adult T-cell leukemia/lymphoma	A peripheral (mature) T-cell neoplasm caused by the human T-cell leukemia virus type 1 (HTLV-1).  Adult T-cell lymphoma/leukemia is endemic in several regions of the world, in particular Japan, the Caribbean, and parts of Central Africa. (WHO, 2001) -- 2003
C3185	Leukemoid_Reaction	Abnormal_Hematology_Test_Result	Leukemoid Reaction
C3186	Leukoplakia	Precancerous_Condition	Leukoplakia|Keratotic Plaque|leukoplakia	(loo-ko-PLAY-kee-a) A white patch that may develop on mucous membranes such as the cheek, gums, or tongue and may become cancerous.
C3187	Oral_Leukoplakia	Leukoplakia|Oral_Cavity_and_Lip_Precancerous_Condition	Oral Leukoplakia|Leukokeratosis of Oral Mucosa|Leukoplakia of Oral Mucosa|Leukoplakia of the Oral Mucosa|Oral Keratoses|Oral Keratosis	A white patch or plaque on oral mucosa that cannot be characterized clinically or pathologically as any other disease. The diagnosis of leukoplakia is one of exclusion; other conditions such as candidiasis, lichen planus, leukoedema, etc. must be ruled out before a diagnosis of leukoplakia can be made. Leukoplakia may be a premalignant condition. --2004
C3188	Leydig_Cell_Tumor	Sex_Cord-Stromal_Tumor	Leydig Cell Tumor|Interstitial Cell Neoplasm|Interstitial Cell Tumor|Leydig Cell Neoplasm
C3189	Lichen_Planus	Dermatitis	Lichen Planus
C3190	Linitis_Plastica	Stomach_Disorder	Linitis Plastica
C3191	Lip_Neoplasm	Lip_Disorder|Oral_Neoplasm	Lip Neoplasm|Lip Neoplasms|Lip Tumor|Neoplasm of Lip|Neoplasm of the Lip|Tumor of Lip|Tumor of the Lip	Abnormal growth of the cells that comprise the lips of the mouth.
C3192	Lipoma	Benign_Lipomatous_Neoplasm	Lipoma	A benign, encapsulated lipomatous tumor composed of mature adipose (fatty) tissue. -- 2003
C3193	Lipomatosis	Benign_Lipomatous_Neoplasm	Lipomatosis
C3194	Liposarcoma	Malignant_Lipomatous_Neoplasm|Sarcoma_of_the_Soft_Tissue_and_Bone	Liposarcoma|liposarcoma	A malignant tumor that arises from adipose tissue (fat).  Microscopically, it may contain a spectrum of neoplastic adipocytes (fat cells) ranging from lipoblasts to pleomorphic malignant adipocytes.  According to the degree of differentiation, liposarcomas may be classified as well differentiated, dedifferentiated, pleomorphic, myxoid, and round cell liposarcomas.  The metastatic potential is higher in less differentiated tumors. -- 2004
C3196	Hepatic_Disorder	Liver_and_Biliary_Tract_Disorder	Hepatic Disorder|Liver Disease|Liver Disorder	Any disease or dysfunction of the liver and the intrahepatic bile ducts.
C3197	Breast_Lump	Mass	Breast Lump|Breast Mass|Breast Nodule|Lump in Breast|Mass in Breast	A mass in the mammary gland, either mobile or immobile. Once the mass has reached the size of a small garden pea, it can be detected by palpation. With mammography a larger number of early breast cancers are being detected since this techniques allows detection prior to the point at which the mass can be felt. Breast masses are not always malignant. Benign fibrocystic breast disease is not uncommon. A fine needle biopsy aspiration can distinguish a cystic mass from a solid one.
C3198	Lung_Disorder	Respiratory_Disorder|Thoracic_Disorder	Lung Disorder|Lung Disorders|Pulmonary Disease|Pulmonary Diseases|Pulmonary Disorder|Pulmonary Disorders|Respiratory Disease|Respiratory Diseases|Respiratory Disorder|Respiratory Disorders|Respiratory System Disease|Respiratory System Diseases|Respiratory System Disorder|Respiratory System Disorders	Diseases of the lung
C3199	Chronic_Obstructive_Airways_Disease	Non-Neoplastic_Lung_Disorder	Chronic Obstructive Pulmonary Disease|COLD|COPD|Chronic Obstructive Airways Disease|Chronic Obstructive Lung Disease	chronic, irreversible obstruction of air flow from the lungs.
C3200	Lung_Neoplasm	Lung_Disorder|Respiratory_Tract_Neoplasm|Thoracic_Neoplasm	Lung Neoplasm|Lung Neoplasms|Lung Tumor|Neoplasm of Lung|Neoplasm of the Lung|Tumor of Lung|Tumor of the Lung
C3201	Systemic_Lupus_Erythematosus	Lupus_Erythematosus	Systemic Lupus Erythematosus|SLE|SLE - Lupus Erythematosus, Systemic|systemic lupus erythematosus	A chronic inflammatory connective tissue disease marked by skin rashes, joint pain and swelling, inflammation of the kidneys, inflammation of the fibrous tissue surrounding the heart (i.e., the pericardium), as well as other problems.  Not all affected individuals display all of these problems.
C3202	Luteoma	Steroid_Cell_Tumor_of_the_Ovary	Ovarian Stromal Luteoma|Luteal Cell Neoplasm|Luteal Cell Tumor|Luteinoma|Luteoma
C3203	Lymphangioendothelioma	Lymphangioma	Acquired Progressive Lymphangioma|Lymphangioendothelioma
C3204	Lymphangiomyoma	Neoplasm_with_Perivascular_Epithelioid_Cell_Differentiation	Lymphangioleiomyoma|Lymphangiomyoma
C3205	Lymphangiosarcoma	Lymphatic_Vessel_Neoplasm|Malignant_Vascular_Neoplasm	Lymphangiosarcoma|Lymphangioendothelial Sarcoma|Malignant Lymphangioendothelioma
C3206	Lymphadenopathy	Hematopoietic_System_Finding	Lymphadenopathy|Adenopathy|Lymphatic Disorders|adenopathy|lymphadenopathy	(ad-en-OP-a-thee) Large or swollen lymph glands.
C3207	Lymphedema	Non-Neoplastic_Vascular_Disorder	Lymphedema|lymphedema	(LIMF-eh-DEE-ma) A condition in which excess fluid collects in tissue and causes swelling. It may occur in the arm or leg after lymph vessels or lymph nodes in the underarm or groin are removed or treated with radiation.
C3208	Lymphoma	Lymphocytic_Neoplasm	Lymphoma|Lymphoma (Hodgkin's and Non-Hodgkin's)|Malignant Lymphoma|lymphoma	(lim-FO-ma) Cancer that arises in cells of the lymphatic system.
C3209	Follicular_Lymphoma	Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Follicular Lymphoma|Follicle Center Lymphoma|Follicular Non-Hodgkin Lymphoma|Follicular Non-Hodgkin's Lymphoma	A neoplasm of follicle centre B cells which has at least a partial follicular pattern.  Follicular lymphomas comprise about 35% of adult non-Hodgkin's lymphomas in the U.S. and 22% worldwide.  Most patients have widespread disease at diagnosis.  Morphologically, follicular lymphomas are classified as Grade 1, Grade 2, and Grade 3, depending on the percentage of the large lymphocytes present.  The vast majority of cases (70-95%) express the BCL-2 rearrangement [t(14;18)].  Histological grade correlates with prognosis.  Grades 1 and 2 follicular lymphomas are indolent and grade 3 is more aggressive (adapted from WHO, 2001). -- 2003
C3210	Mixed_Cell_Lymphoma	Intermediate-Grade_Lymphoma	Mixed Cell Lymphoma|Mixed Lymphocytic-Histiocytic Lymphoma
C3211	Non-Hodgkin_s_Lymphoma	Common_Hematopoietic_Neoplasm|Lymphoma	Non-Hodgkin's Lymphoma|NHL|Non-Hodgkin Lymphoma|Non-Hodgkins Lymphoma|non-Hodgkin's lymphoma	A group of cancers of the lymphoid system, including acute lymphoblastic leukemia, B-cell lymphoma, Burkitt's lymphoma, diffuse cell lymphoma, follicular lymphoma, immunoblastic large cell lymphoma, lymphoblastic lymphoma, mantle cell lymphoma, mycosis fungoides, post-transplantation lymphoproliferative disorder, small non-cleaved cell lymphoma, and T-cell lymphoma.
C3212	Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia	Indolent_Non-Hodgkin_s_Lymphoma|Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia|Immunocytoma, Lymphoplasmacytic Type|Lymphoplasmacytic Lymphoma|Lymphoplasmacytic Lymphoma/Waldenstrom Macroglobulinemia|Lymphoplasmacytoid Lymphoma|Macroglobulinemia|Waldenstrom's Macroglobulinemia|Waldenstrom's macroglobulinemia|macroglobulinemia	(MAK-ro-GLOB-u-li-NE-me-uh) A condition in which the blood contains high levels of large proteins and is too thick to flow through small blood vessels. One type is Waldenstrom's macroglobulinemia, which is a type of cancer.
C3213	Maffucci_Syndrome	Hereditary_Neoplastic_Syndrome	Maffucci Syndrome|Chondrodysplasia with Hemangioma|Chondroplasia Angiomatosis|Dyschondroplasia and Cavernous Hemangioma|Enchondromatosis with Hemangiomata|Hemangiomata with Dyschondroplasia|Maffucci's Anomalad
C3214	Malabsorption_Syndrome	Intestinal_Disorder|Syndrome	Malabsorption Syndrome|malabsorption syndrome	A group of symptoms such as gas, bloating, abdominal pain, and diarrhea resulting from the body's inability to properly absorb nutrients.
C3215	Carcinoid_Syndrome	Ectopic_Hormone_Secretion_Syndromes_Associated_with_Neoplasia	Carcinoid Syndrome
C3216	Malignant_Retinal_Neoplasm	Malignant_Eye_Neoplasm|Retinal_Disorder|Retinal_Neoplasm	Malignant Retinal Neoplasm|Malignant Neoplasm of Retina|Malignant Neoplasm of the Retina|Malignant Retina Neoplasm|Malignant Retina Tumor|Malignant Retinal Tumor|Malignant Tumor of Retina|Malignant Tumor of the Retina	Abnormal growth of cells comprising the retina with malignant characteristics.
C3217	Benign_Mastocytoma	Mastocytoma	Benign Mastocytoma
C3218	Diffuse_Cutaneous_Mastocytosis	Pure_Cutaneous_Mastocytosis	Diffuse Cutaneous Mastocytosis	A variant of cutaneous mastocytosis which is seen almost exclusively in children. (WHO, 2001) -- 2003
C3219	Maxillary_Sinus_Neoplasm	Paranasal_Sinus_Neoplasm	Maxillary Sinus Neoplasm|Maxillary Antrum Neoplasm|Maxillary Antrum Tumor|Maxillary Sinus Tumor|Maxillofacial Sinus Neoplasm|Maxillofacial Sinus Tumor|Neoplasm of Maxillary Antrum|Neoplasm of Maxillary Sinus|Neoplasm of Maxillofacial Sinus|Neoplasm of the Maxillary Antrum|Neoplasm of the Maxillary Sinus|Neoplasm of the Maxillofacial Sinus|Tumor of Maxillary Antrum|Tumor of Maxillary Sinus|Tumor of Maxillofacial Sinus|Tumor of the Maxillary Antrum|Tumor of the Maxillary Sinus|Tumor of the Maxillofacial Sinus
C3220	Mediastinal_Cyst	Cyst	Mediastinal Cyst|Cyst of Mediastinum|Cyst of the Mediastinum
C3221	Mediastinal_Neoplasm	Mediastinal_Disorder|Thoracic_Neoplasm	Mediastinal Neoplasm|Mediastinal Neoplasm NOS|Mediastinal Tumor|Neoplasm of Mediastinum|Neoplasm of the Mediastinum|Tumor of Mediastinum|Tumor of the Mediastinum	Abnormal growth of the cells of the tissues contained within the mediastinum e.g. thymus.
C3222	Medulloblastoma	Central_Nervous_System_Primitive_Neuroectodermal_Tumor	Medulloblastoma|Medulloblastomas|medulloblastoma	(MED-yoo-lo-blas-TOE-ma) A malignant brain tumor that begins in the lower part of the brain and that can spread to the spine or to other parts of the body. Medulloblastomas are a type of primitive neuroectodermal tumor (PNET).
C3223	Meigs_Syndrome	Cancer-Related_Condition|Syndrome	Meigs' Syndrome
C3224	Melanoma	Common_Neoplasm|Melanocytic_Neoplasm	Melanoma|Malignant Melanoma|melanoma	A form of skin cancer that arises in melanocytes, the cells that produce pigment. Melanoma usually begins in a mole.
C3225	Multiple_Endocrine_Neoplasia_Type_I	Multiple_Endocrine_Neoplasia	Multiple Endocrine Neoplasia Type I|MEA Type 1|MEA Type I|MEN Type 1|MEN Type I|Multiple Endocrine Adenomatosis Type 1|Multiple Endocrine Adenomatosis Type I|Multiple Endocrine Adenomatosis, Type I|Multiple Endocrine Neoplasia Type 1|Multiple Endocrine Neoplasia, Type I|Wermer's Syndrome	The MEN1 gene is a cloned tumor suppressor gene for Multiple Endocrine Neoplasia, a predisposition for endocrine tumors and carcinoid tumors.  The gene encodes the tumor suppressor protein MEN1, which regulates transcription through direct interaction with, and inhibition of, transcription factor JunD.  Menin also interacts with SMAD3 and appears to be required for SMAD3/4-DNA binding at transcriptional regulatory sites.  The human gene is located at 11q13.
C3226	Multiple_Endocrine_Neoplasia_Type_II	Multiple_Endocrine_Neoplasia	Multiple Endocrine Neoplasia, Type II|MEA Type 2a|MEA Type II|MEN Type 2a|MEN Type II|Multiple Endocrine Adenomatosis Type 2A|Multiple Endocrine Adenomatosis Type 2a|Multiple Endocrine Adenomatosis Type II|Multiple Endocrine Adenomatosis, Type II|Multiple Endocrine Neoplasia Type 2A|Multiple Endocrine Neoplasia Type 2a|Multiple Endocrine Neoplasia Type II
C3227	Multiple_Endocrine_Neoplasia_Type_III	Multiple_Endocrine_Neoplasia	Multiple Endocrine Neoplasia Type III|MEN 2B|MEN IIB|MEN Type 2B|MEN Type IIB|Multiple Endocrine Adenomatosis Type 2B|Multiple Endocrine Adenomatosis Type IIB|Multiple Endocrine Neoplasia Type 2b|Multiple Endocrine Neoplasia Type IIB
C3228	Menarche	Reproductive_System_Process	Menarche	Onset of menses.
C3229	Meningeal_Neoplasm	Central_Nervous_System_Neoplasm	Meningeal Neoplasm|Meningeal Neoplasms|Meningeal Tumor|Meninges Neoplasm|Meninges Tumor|Neoplasm of Meninges|Neoplasm of the Meninges|Tumor of Meninges|Tumor of the Meninges	A tumor that involves the tissues that cover the brain and spinal cord.
C3230	Meningioma	Meningeal_Neoplasm|Meningothelial_Cell_Neoplasm	Meningioma|meningioma	(meh-nin-jee-O-ma) A type of tumor that occurs in the meninges, the membranes that cover and protect the brain and spinal cord. Meningiomas usually grow slowly.
C3231	Menopause	Reproductive_System_Process	Menopause|MENP|menopause	(MEN-o-pawz) The time of life when a woman's menstrual periods stop permanently. Also called "change of life."
C3232	Menstruation	Endocrine_System_Signs_and_Symptoms	Menstruation|MENS|Menses|menstruation	Periodic discharge of blood and tissue from the uterus.  Until menopause, menstruation occurs approximately every 28 days when a woman is not pregnant.
C3233	Mesenchymoma	Soft_Tissue_Neoplasm	Mesenchymoma	An obsolete term describing a soft tissue tumor which consists of two or more mesenchymal lines of differentiation, excluding a fibroblastic line of differentiation. --2003
C3234	Mesothelioma	Mesothelial_Neoplasm	Mesothelioma|mesothelioma	A benign (noncancerous) or malignant (cancerous) tumor affecting the lining of the chest or abdomen.  Exposure to asbestos particles in the air increases the risk of developing malignant mesothelioma.
C3235	Metabolic_Disorder	Diseases_and_Disorders	Metabolic Disorder|Metabolic Disease|Metabolic Diseases|metabolic disorder	A condition in which normal metabolic processes are disrupted, usually because of a missing enzyme.
C3236	Metaplasia	Morphologic_Finding	Metaplasia|Metaplastic Change|metaplasia	A change of cells to a form that does not normally occur in the tissue in which it is found.
C3237	Squamous_Metaplasia	Metaplasia	Squamous Metaplasia
C3238	Milium_Cyst	Skin_Cyst	Milium Cyst|Milia|Milium
C3239	Monosomy	Numerical_Chromosome_Aberration	Monosomy
C3240	Oral_Disorder	Head_and_Neck_Disorder	Oral Disorder|Oral Disease
C3241	Appendicele_Mucocele	Gastrointestinal_System_Finding	Mucocele of the Appendix|Appendiceal Mucocele|Appendicele Mucocele|Mucocele of Appendix
C3242	Plasma_Cell_Myeloma	Common_Hematopoietic_Neoplasm|Plasma_Cell_Neoplasm	Plasma Cell Myeloma|Multiple Myeloma|Myeloma|multiple myeloma|myeloma	(mye-eh-LO-ma) Cancer that arises in plasma cells (white blood cells that produce antibodies).
C3243	Multiple_Sclerosis	Autoimmune_Disease|Non-Neoplastic_Central_Nervous_System_Disorder	Multiple Sclerosis|multiple sclerosis	A disorder of the central nervous system marked by weakness, numbness, a loss of muscle coordination, and problems with vision, speech, and bladder control. Multiple sclerosis is thought to be an autoimmune disease in which the body's immune system destroys myelin. Myelin is a substance that contains both protein and fat (lipid), serving as a nerve insulator and helping in the transmission of nerve signals.
C3244	Musculoskeletal_Pain	Pain	Musculoskeletal Pain	Discomfort referable to either the muscles or the bones themselves.
C3245	Fungal_Infection	Infectious_Disorder	Fungal Infection	An infection caused by eukaryotic heterotrophic organisms that live as saprobes or parasites, including mushrooms, yeasts, smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi refer to those that grow as multicellular colonies (mushrooms and molds).
C3246	Mycosis_Fungoides	Cutaneous_T-Cell_Lymphoma|Indolent_Non-Hodgkin_s_Lymphoma|Mycosis_Fungoides_and_Sezary_Syndrome	Mycosis Fungoides|MF|mycosis fungoides	(mye-KO-sis fun-GOY-deez) A type of non-Hodgkin's lymphoma that first appears on the skin and can spread to the lymph nodes or other organs such as the spleen, liver, or lungs.
C3247	Myelodysplastic_Syndrome	Common_Hematopoietic_Neoplasm|Myeloid_Neoplasm|Premalignant_Hematologic_Condition|Syndrome	Myelodysplastic Syndrome|Dysmyelopoietic Syndrome|MDS|Myelodysplasia|Myelodysplastic Syndromes|Oligoblastic Leukemia|Preleukemia|Smoldering Leukemia|myelodysplasia|myelodysplastic syndrome|preleukemia|smoldering leukemia	(MYE-eh-lo-dis-PLAS-tik SIN-drome) Disease in which the bone marrow does not function normally.
C3248	Myelofibrosis	Bone_Marrow_Disorder	Myelofibrosis|myelofibrosis	A disorder in which the bone marrow is replaced by fibrous tissue.
C3249	Acute_Myeloid_Leukemia_without_Maturation	Acute_Myeloid_Leukemia_not_Otherwise_Categorized	Acute Myeloid Leukemia without Maturation|Acute Granulocytic Leukemia without Maturation|Acute M1 Myeloid Leukemia|Acute Myeloblastic Leukemia without Maturation|Acute Myelocytic Leukemia without Maturation|Acute Myelogenous Leukemia without Maturation|Acute Myeloid Leukemia without Maturation (FAB M1)|FAB M1|M1 Acute Granulocytic Leukemia|M1 Acute Granulocytic Leukemia without Maturation|M1 Acute Myeloblastic Leukemia|M1 Acute Myeloblastic Leukemia without Maturation|M1 Acute Myelocytic Leukemia|M1 Acute Myelocytic Leukemia without Maturation|M1 Acute Myelogenous Leukemia|M1 Acute Myelogenous Leukemia without Maturation|M1 Acute Myeloid Leukemia|M1 Acute Myeloid Leukemia without Maturation	An acute myeloid leukemia (AML) characterized by blasts without evidence of maturation to more mature neutrophils.  The patients present with anemia, neutropenia, and thrombocytopenia.  This type of AML usually follows an aggressive clinical course.  (WHO, 2001) -- 2003
C3250	Acute_Myeloid_Leukemia_with_Maturation	Acute_Myeloid_Leukemia_not_Otherwise_Categorized	Acute Myeloid Leukemia with Maturation|Acute M2 Myeloid Leukemia|Acute Myeloblastic Leukemia with Maturation|Acute Myelocytic Leukemia with Maturation|Acute Myelogenous Leukemia with Maturation|Acute Myeloid Leukemia (AML-M2)|FAB M2|M2 Acute Granulocytic Leukemia|M2 Acute Myeloblastic Leukemia|M2 Acute Myeloblastic Leukemia with Maturation|M2 Acute Myelocytic Leukemia with Maturation|M2 Acute Myelogenous Leukemia|M2 Acute Myelogenous Leukemia with Maturation|M2 Acute Myeloid Leukemia|M2 Acute Myeloid Leukemia with Maturation	An acute myeloid leukemia (AML) characterized by blasts with evidence of maturation to more mature neutrophils.  The patients often present with anemia, neutropenia, and thrombocytopenia.  AML with the t(8;21) is usually AML with maturation.  This type of AML responds frequently to aggressive therapy.  (WHO, 2001) -- 2003
C3252	Benign_Granular_Cell_Tumor	Granular_Cell_Tumor	Benign Granular Cell Tumor|Benign Granular Cell Myoblastoma|Benign Granular Cell Neoplasm|Myoblastoma
C3253	Myositis_Ossificans	Non-Neoplastic_Soft_Tissue_Disorder	Myositis Ossificans
C3254	Angiomyxoma	Myxoma	Angiomyxoma
C3255	Myxosarcoma	Soft_Tissue_Sarcoma	Myxosarcoma
C3256	Nasal_Cavity_Polyp	Benign_Nasal_Cavity_Neoplasm|Polyp	Nasal Cavity Polyp|Nasal Polyp|Polyp of Nasal Cavity|Polyp of the Nasal Cavity
C3257	Nasopharyngeal_Neoplasm	Nasopharyngeal_Disorder|Pharyngeal_Neoplasm	Nasopharyngeal Neoplasm|Nasopharyngeal Neoplasms|Nasopharyngeal Tumor|Neoplasm of Nasopharynx|Neoplasm of the Nasopharynx|Tumor of Nasopharynx|Tumor of the Nasopharynx
C3258	Nausea	Nausea_and_Vomiting	Nausea	The sensation that one is about to vomit.
C3259	Nausea_and_Vomiting	Gastrointestinal_System_Signs_and_Symptoms	Nausea and Vomiting|Vomiting and Nausea
C3260	Neck_Neoplasm	Head_and_Neck_Neoplasm|Neck_Disorder	Neck Neoplasm|Neck Neoplasms (Including All Pharyngeal Related Neoplasms)|Neck Tumor|Neoplasm of Neck|Neoplasm of the Neck|Tumor of Neck|Tumor of the Neck
C3261	Metastatic_Neoplasm	Neoplasm_by_Special_Category	Metastatic Neoplasm|Metastatic Tumor	A tumor that has spread from its original (primary) site of growth to another site, close to or distant from the primary site.  Metastasis is characteristic of advanced malignancies, but in rare instances can be seen in neoplasms lacking malignant morphology. -- 2004
C3262	Neoplasm	Diseases_and_Disorders	Neoplasm|Neoplasia|Neoplasms|Neoplastic Growth|Tumor|neoplasia|neoplasm|tumor	(NEE-o-PLAY-zha) Abnormal and uncontrolled cell growth.
C3263	Neoplasm_by_Site	Neoplasm	Neoplasm by Site
C3264	Embryonal_Neoplasm	Neoplasm_by_Special_Category	Embryonal Neoplasm	A usually malignant neoplasm composed of primitive (immature) tissues that resemble fetal tissues.  Medulloblastoma, Ependymoblastoma, Pineoblastoma, and Wilms tumor are representative embryonal neoplasms. --2003
C3265	Radiation-Related_Neoplasm	Neoplasm_by_Cause|Radiation-Induced_Abnormalities	Radiation-Related Neoplasm|Radiation Induced Neoplasm|Radiation-Induced Neoplasm
C3266	Hereditary_Neoplastic_Syndrome	Genetic_Disorder|Syndrome	Hereditary Neoplastic Syndrome|Familiar Neoplastic Syndrome	The inherited predisposition toward getting a cancer
C3267	Wilms_Tumor	Embryonal_Neoplasm|Malignant_Mixed_Neoplasm	Wilms' Tumor|Wilms Tumor
C3268	Nervous_System_Neoplasm	Neoplasm_by_Site|Nervous_System_Disorder	Nervous System Neoplasm|Neoplasm of Nervous System|Neoplasm of the Nervous System|Nervous System Neoplasms|Nervous System Tumor|Nervous System Tumour|Tumor of Nervous System|Tumor of the Nervous System	Abnormal growth of the cells that comprise the tissues of the central or peripheral nervous system, without specification as to whether the growth is benign or malignant in nature.
C3269	Schwannoma	Peripheral_Nerve_Sheath_Neoplasm	Schwannoma|Neurilemmoma|Neurinoma|schwannoma	(shwah-NO-ma)
C3270	Neuroblastoma	Neuroblastic_Tumor	Neuroblastoma|Neuroblastoma (Schwannian Stroma-Poor)|neuroblastoma	Cancer that arises in immature nerve cells and affects mostly infants and children.
C3272	Neurofibroma	Peripheral_Nerve_Sheath_Neoplasm|Peripheral_Nervous_System_Neoplasm	Neurofibroma|neurofibroma	A benign tumor that develops from the cells and tissues that cover nerves.
C3273	Neurofibromatosis_Type_1	Neurofibromatosis	Neurofibromatosis Type 1|Peripheral Neurofibromatosis|Von Recklinghausen Disease|neurofibromatosis type 1	NF1. A rare genetic condition that causes brown spots and tumors on the skin, freckling in skin areas not exposed to the sun, tumors on the nerves, and developmental changes in the nervous system, muscles, bone, and skin.
C3274	Neurofibromatosis_Type_2	Neurofibromatosis	Neurofibromatosis Type 2|Acoustic Neurofibromatosis|Bilateral Acoustic Neurofibromatosis|Central Neurofibromatosis|acoustic neurofibromatosis|neurofibromatosis type 2	A genetic condition in which tumors form on the nerves of the inner ear and cause loss of hearing and balance.  Tumors may also occur in the brain and on nerves in the skull and spinal cord, and may cause loss of speech, eye movement, and the ability to swallow.
C3275	Neuroma	Non-Neoplastic_Peripheral_Nervous_System_Disorder	Neuroma|neuroma	(noo-RO-ma) A tumor that arises in nerve cells.
C3276	Acoustic_Schwannoma	Schwannoma|Vestibulocochlear_Nerve_Neoplasm	Acoustic Schwannoma|Acoustic Neurilemmoma|Acoustic Neurinoma|Acoustic Neuroma|Neurilemoma, Acoustic|Neuroma, Acoustic|Vestibular Neurilemmoma|Vestibular Schwannoma	A type of benign brain tumor that begins in the Schwann cells, which produce the myelin that protects the acoustic nerve - the nerve of hearing.
C3277	Neutropenia	Retired_Concepts	Neutropenia|Granulocytopenia|granulocytopenia|neutropenia	A decrease in the number of mature granulocytes (neutrophils, eosinophils, and basophils) in the peripheral blood. -- 2004
C3279	Night_Sweating	Sweating	Night Sweating|Night Sweats
C3280	Nodule	Other_Finding	Nodule|NDUL|nodule	(NOD-yool) A growth or lump that may be cancerous or noncancerous.
C3282	Nystagmus	Non-Neoplastic_Central_Nervous_System_Disorder|Non-Neoplastic_Eye_Disorder	Nystagmus	Involuntary movements of the eyeballs.  The presence or absence of nystagmus is often used in the diagnosis of a variety of neurological and visual disorders.
C3283	Obesity	Symptom	Obesity	Having a high amount of body fat. A person is considered obese if they have a body mass index (BMI) of 30 or more.
C3284	Obstruction	Finding_by_Cause	Obstruction|OBSTR|obstruction	Blockage of a passageway.
C3285	Ocular_Hypertension	Hypertension	Ocular Hypertension
C3286	Odontogenic_Neoplasm	Dental_Disorder|Infrequent_Neoplasm|Neoplasm_by_Morphology|Oral_Cavity_Neoplasm	Odontogenic Neoplasm|Odontogenic Tumor
C3287	Odontoma	Benign_Odontogenic_Neoplasm	Odontoma|Fibro-Odontoma|Fibroodontoma
C3288	Oligodendroglioma	Oligodendroglial_Tumor	Oligodendroglioma|WHO Grade II Oligodendroglial Neoplasm|WHO Grade II Oligodendroglial Tumor|Well Differentiated Oligodendroglial Tumor|Well Differentiated Oligodendroglioma|oligodendroglioma	(OL-ih-go-den-dro-glee-O-ma) A rare, slow-growing tumor that begins in the oligodendrocytes (brain cells that provide support and nourishment for nerve cells).  Also called an oligodendroglial tumor.
C3289	Opportunistic_Infections	Infectious_Disorder	Opportunistic Infection|opportunistic infection	An infection caused by an organism that does not normally cause disease. Opportunistic infections occur in people with weakened immune systems.
C3290	Orbit_Neoplasm	Skull_Neoplasm	Orbit Neoplasm|Neoplasm of Orbit|Neoplasm of the Orbit|Orbit Tumor|Orbital Neoplasm|Orbital Neoplasms|Orbital Tumor|Tumor of Orbit|Tumor of the Orbit
C3291	Oropharyngeal_Neoplasm	Pharyngeal_Neoplasm	Oropharyngeal Neoplasm|Neoplasm of Oropharynx|Neoplasm of the Oropharynx|Oropharyngeal Neoplasms|Oropharyngeal Tumor|Tumor of Oropharynx|Tumor of the Oropharynx	Abnormal growth of the cells that comprise the oropharynx.
C3292	Bone_Paget_s_Disease	Non-Neoplastic_Bone_Disorder	Bone Paget's Disease|Osseous Paget's Disease|Osteitis Deformans|Paget's Disease|Paget's Disease of Bone|Paget's Disease of the Bone|Pagets Disease (Bone)	Paget's Disease is a disease of bone that initially results in the excessive resorption of bone (by osteoclasts) followed by the replacement of normal bone marrow with vascular and fibrous tissue. (On-line Medical Dictionary)
C3293	Osteoarthritis	Arthritis	Osteoarthritis	Noninflammatory degenerative joint disease occurring chiefly in older persons, characterised by degeneration of the articular cartilage, hypertrophy of bone at the margins and changes in the synovial membrane. It is accompanied by pain and stiffness, particularly after prolonged activity. (On-line Medical Dictionary)
C3294	Osteoblastoma	Benign_Bone_Neoplasm|Benign_Osteogenic_Neoplasm	Osteoblastoma
C3295	Osteochondroma	Benign_Chondrogenic_Neoplasm	Osteochondroma|Bone Chondroma|Chondroma of Bone|Chondroma of the Bone|Osseous Chondroma
C3296	Osteoma	Benign_Osteogenic_Neoplasm	Osteoma
C3297	Osteoid_Osteoma	Osteoma	Osteoid Osteoma
C3298	Osteoporosis	Non-Neoplastic_Bone_Disorder	Osteoporosis|osteoporosis	(OSS-tee-oh-pa-ROW-sis) A condition that is characterized by a decrease in bone mass and density, causing bones to become fragile.
C3299	External_Ear_Infection	Non-Neoplastic_External_Ear_Disorder|Otitis	External Ear Infection|Inflammation of External Auditory Canal|Inflammation of the External Auditory Canal|Otitis Externa
C3300	Ovarian_Cyst	Cyst|Reproductive_System_Finding	Ovarian Cyst|Cyst of Ovary|Cyst of the Ovary
C3301	Paget_s_Disease_of_the_Nipple	Nipple_Carcinoma|Paget_s_Disease_of_the_Breast	Paget's Disease of the Nipple|Nipple Paget's Disease|Paget's Disease of Nipple|Paget's disease of the nipple	A form of breast cancer in which the tumor grows from ducts beneath the nipple onto the surface of the nipple. Symptoms commonly include itching and burning and an eczema-like condition around the nipple, sometimes accompanied by oozing or bleeding.
C3302	Extramammary_Paget_s_Disease	Apocrine_Carcinoma|Paget_s_Cell_Neoplasm	Extramammary Paget's Disease|Cutaneous Paget's Disease|Paget's Disease of Skin|Paget's Disease of the Skin|Paget's Skin Disease	Atypical cells within the epidermal layer of the skin that can be confused with the cells seen in Bowen's disease. These cells are large with hyperchromatic nuclei. Mitoses are frequently encountered. This condition is most commonly associated with the breast but can involve the anogenital area, axilla, eyelid, external auditory canal. (Devita et al. Cancer. p.1588 4th edition Lippincott)
C3303	Pain	Symptom	Pain|PN	The sensation of discomfort, distress, or agony, resulting from the stimulation of specialized nerve endings.
C3304	Pancreatic_Cyst	Cyst|Gastrointestinal_System_Finding	Pancreatic Cyst|Cyst of Pancreas|Cyst of the Pancreas|Pancreas Cyst
C3305	Pancreatic_Neoplasm	Gastrointestinal_Neoplasm|Pancreatic_Disorder	Pancreatic Neoplasm|Neoplasm of Pancreas|Neoplasm of the Pancreas|Pancreas Neoplasm|Pancreas Tumor|Pancreatic Tumor|Tumor of Pancreas|Tumor of the Pancreas	Abnormal growth of the cells (either cancerous or non-cancerous) of the pancreas, the gland that secrets insulin.
C3306	Pancreatitis	Pancreatic_Disorder	Pancreatitis|pancreatitis	Inflammation of the pancreas. Chronic pancreatitis may cause diabetes and problems with digestion. Pain is the primary symptom.
C3307	Papilledema	Edema	Papilledema|papilledema	(pap-il-eh-DEE-ma) Swelling around the optic disk, the area where the optic nerve (the nerve that carries messages from the eye to the brain) enters the eyeball. Papilledema occurs when increased brain pressure caused by tumors or other problems results in swelling of the optic nerve.
C3308	Paraganglionic_Neoplasm	Autonomic_Nervous_System_Neoplasm|Neuroendocrine_Neoplasm	Paraganglioma|Neoplasm of Paraganglion|Neoplasm of the Paraganglion|Paraganglion Neoplasm|Paraganglion Tumor|Paraganglionic Neoplasm|Paraganglionic Tumor|Tumor of Paraganglion|Tumor of the Paraganglion	A benign or malignant neoplasm arising from paraganglia located along the sympathetic or parasympathetic nerves.  Infrequently, it may arise outside the usual distribution of the sympathetic and parasympathetic paraganglia.  Tumors arising from the adrenal gland medulla are called pheochromocytomas.  Morphologically, paragangliomas usually display a nesting (Zellballen) growth pattern.  There are no reliable morphologic criteria to distinguish between benign and malignant paragangliomas.  The only definitive indicator of malignancy is the presence of regional or distant metastases.
C3309	Extra-Adrenal_Paraganglioma	Paraganglionic_Neoplasm	Extra-Adrenal Paraganglioma|Extra-Adrenal Paraganglionic Neoplasm|Extraadrenal Paraganglioma	A benign or malignant paraganglioma arising from sympathetic or parasympathetic paraganglia outside the adrenal gland.
C3310	Paralysis	Motor_Manifestations	Paralysis|paralysis	(pa-RAL-ih-sis) Loss of ability to move all or part of the body.
C3311	Paraneoplastic_Syndrome	Cancer-Related_Condition|Syndrome	Paraneoplastic Syndrome|paraneoplastic syndrome	(pair-a-nee-o-PLAS-tik) A group of symptoms that may develop when substances released by some cancer cells disrupt the normal function of surrounding cells and tissue.
C3312	Parapsoriasis	Cutaneous_Precancerous_Condition	Parapsoriasis
C3313	Parathyroid_Neoplasm	Neck_Neoplasm|Parathyroid_Gland_Disorder	Parathyroid Gland Neoplasm|Neoplasm of Parathyroid|Neoplasm of Parathyroid Gland|Neoplasm of the Parathyroid|Neoplasm of the Parathyroid Gland|Parathyroid Gland Tumor|Parathyroid Neoplasm|Parathyroid Tumor|Tumor of Parathyroid|Tumor of Parathyroid Gland|Tumor of the Parathyroid|Tumor of the Parathyroid Gland	A benign or malignant neoplasm affecting the parathyroid glands. (NCI05)
C3314	Parotid_Gland_Neoplasm	Major_Salivary_Gland_Neoplasm	Parotid Gland Neoplasm|Neoplasm of Parotid|Neoplasm of Parotid Gland|Neoplasm of the Parotid|Neoplasm of the Parotid Gland|Parotid Gland Tumor|Parotid Neoplasm|Parotid Tumor|Tumor of Parotid|Tumor of Parotid Gland|Tumor of the Parotid|Tumor of the Parotid Gland
C3315	Partial_Thromboplastin_Time	Retired_Concepts	Partial Thromboplastin Time|PTT
C3316	Penile_Fibromatosis	Benign_Cutaneous_Fibrous_Neoplasm|Superficial_Fibromatosis	Penile Fibromatosis|Peyronie's Disease|Peyronie's Fibromatosis
C3317	Penile_Neoplasm	Male_Reproductive_System_Neoplasm|Penile_Disorder	Penile Neoplasm|Neoplasm of Penis|Neoplasm of the Penis|Penile Neoplasms|Penile Tumor|Tumor of Penis|Tumor of the Penis
C3318	Peptic_Ulcer	Non-Neoplastic_Gastrointestinal_Disorder	Peptic Ulcer|Peptic Ulcer Disease
C3319	Pericardial_Effusion	Effusion	Pericardial Effusion|pericardial effusion	An abnormal collection of fluid inside the sac that covers the heart.
C3321	Peripheral_Nervous_System_Neoplasm	Nervous_System_Neoplasm|Peripheral_Nervous_System_Disorder	Peripheral Nervous System Neoplasm|Neoplasm of PNS|Neoplasm of Peripheral Nerve|Neoplasm of Peripheral Nervous System|Neoplasm of the PNS|Neoplasm of the Peripheral Nerve|Neoplasm of the Peripheral Nervous System|Neoplasms, PNS|Neoplasms, Peripheral Nervous System|PNS Neoplasm|PNS Neoplasms|PNS Tumor|Peripheral Nerve Neoplasm|Peripheral Nerve Tumor|Peripheral Nervous System Tumor|Tumor of PNS|Tumor of Peripheral Nerve|Tumor of Peripheral Nervous System|Tumor of the PNS|Tumor of the Peripheral Nerve|Tumor of the Peripheral Nervous System	A benign or malignant neoplasm arising from a peripheral nerve or the perineural sheaths. -- 2003
C3322	Peritoneal_Neoplasm	Peritoneal_Disorder|Peritoneal_and_Retroperitoneal_Neoplasms	Peritoneal Neoplasm	Abnormal growth of cells in the peritoneum
C3323	Petechia	Hemorrhage	Petechia|Petechiae|petechiae	(peh-TEH-kee-a) Pinpoint, unraised, round red spots under the skin caused by bleeding.
C3324	Peutz-Jeghers_Syndrome	Hereditary_Neoplastic_Syndrome	Peutz-Jeghers Syndrome	An inherited condition characterized by generalized hamartomatous multiple polyposis of the intestinal tract. Transmitted in an autosomal dominant fashion, Peutz-Jeghers syndrome consistently involves the jejunum and is associated with melanin spots of the lips, buccal mucosa, and fingers. This syndrome is associated with abnormalities of chromosome 19. Also known as Jeghers-Peutz syndrome and Peutz's syndrome. --2004
C3325	Pharyngeal_Neoplasm	Neck_Neoplasm|Pharyngeal_Disorder	Pharyngeal Neoplasm|Neoplasm of Pharynx|Neoplasm of the Pharynx|Pharyngeal Neoplasms|Pharyngeal Tumor|Pharynx Neoplasm|Pharynx Tumor|Tumor of Pharynx|Tumor of the Pharynx
C3326	Pheochromocytoma	Adrenal_Medulla_Neoplasm|Sympathetic_Paraganglioma	Adrenal Gland Pheochromocytoma|Adrenal Gland Chromaffin Paraganglioma|Adrenal Gland Chromaffinoma|Adrenal Gland Paraganglioma|Adrenal Medullary Paraganglioma|Adrenal Medullary Pheochromocytoma|Adrenal Pheochromocytoma|Chromaffin Paraganglioma of the Adrenal Gland|Intraadrenal Paraganglioma|PCC|Phaeochromocytoma|Pheochromocytoma	A benign or malignant neuroendocrine neoplasm of the sympathetic nervous system that secretes catecholamines.  It arises from the chromaffin cells of the adrenal medulla.  Clinical presentation includes headaches, palpitations, chest and abdominal pain, hypertension, fever, and tremor.  Microscopically, a characteristic nesting (zellballen) growth pattern is usually seen.  Other growth patterns including trabecular pattern may also be present. (NCI05)
C3327	Skin_Discoloration	Integumentary_System_Finding	Skin Discoloration	A change from the patient's baseline skin coloration.
C3328	Pineal_Region_Neoplasm	Supratentorial_Neoplasm	Pineal Region Neoplasm|Neoplasm of Pineal Area|Neoplasm of Pineal Region|Neoplasm of the Pineal Area|Neoplasm of the Pineal Region|Pineal Area Neoplasm|Pineal Area Tumor|Pineal Body Neoplasm|Pineal Body Tumor|Pineal Neoplasm|Pineal Region Tumor|Pineal Tumor|Pinealoma|Tumor of Pineal Area|Tumor of Pineal Region|Tumor of the Pineal Area|Tumor of the Pineal Region|pineal region tumor	(pIN-ee-al...) A type of brain tumor that occurs in or around the pineal gland, a tiny organ near the center of the brain.
C3329	Pituitary_Gland_Adenoma	Adenoma|Anterior_Pituitary_Gland_Neoplasm	Pituitary Gland Adenoma|Adenoma of Pituitary|Adenoma of Pituitary Gland|Adenoma of the Pituitary|Adenoma of the Pituitary Gland|Pituitary Adenoma	Abnormal growth of cells in the pituitary gland that can either secrete hormone or not.  The diagnosis can be based on imaging studies and/or radioimmunoassays.  Due to their location in the sella turcica, expansion of the tumor mass can impinge on the optic chiasm or involve the temporal lobe, third ventricle and posterior fossa.  A frequently associated physical finding is bitemporal hemianopsia which may progress to further visual loss.
C3330	Pituitary_Gland_Neoplasm	Pituitary_Gland_Disorder|Sella_Turcica_Neoplasm|Supratentorial_Neoplasm	Pituitary Gland Neoplasm|Neoplasm of Pituitary|Neoplasm of Pituitary Gland|Neoplasm of the Pituitary|Neoplasm of the Pituitary Gland|Pituitary Gland Tumor|Pituitary Neoplasm|Pituitary Neoplasms|Pituitary Tumor|Tumor of Pituitary|Tumor of Pituitary Gland|Tumor of the Pituitary|Tumor of the Pituitary Gland	A benign or malignant neoplasm affecting the pituitary gland.  The vast majority are adenomas arising from the anterior lobe of the pituitary gland. (NCI05)
C3331	Pleural_Effusion	Effusion	Pleural Effusion|pleural effusion	An abnormal collection of fluid between the thin layers of tissue (pleura) lining the lung and the wall of the chest cavity.
C3332	Pleural_Neoplasm	Pleural_Disorder|Thoracic_Neoplasm	Pleural Neoplasm|Neoplasm of Pleura|Neoplasm of the Pleura|Pleural Tumor|Tumor of Pleura|Tumor of the Pleura	A benign or malignant neoplasm that involves the serous membrane that lines the lungs and thoracic cavity. Most pleural neoplasms are metastatic. Diffuse malignant mesothelioma is the most common primary malignant neoplasm of the pleura. --2004
C3333	Pneumonia	Non-Neoplastic_Lung_Disorder	Pneumonia|Pneumonitis|pneumonia	(noo-MONE-ya) An inflammatory infection that occurs in the lung.
C3334	Pneumocystis_Carinii_Pneumonia	Pneumonia	Pneumocystis Carinii Pneumonia	Pneumocystis carinii pneumonia (PCP). pneumonia resulting from infection with Pneumocystis carinii, frequently seen in the immunologically compromised, such as persons with AIDS, or steroid-treated individuals, the elderly, or premature or debilitated babies during their first three months.  Patients may be only slightly febrile (or even afebrile), but are likely to be extremely weak, dyspneic, and cyanotic. This is a major cause of morbidity among patients with AIDS.
C3335	Rothmund-Thomson_Syndrome	Hereditary_Neoplastic_Syndrome	Rothmund-Thomson Syndrome|RTS
C3336	Polycythemia_Vera	Chronic_Myeloproliferative_Disorder|Erythroid_Neoplasm|Polycythemia	Polycythemia Vera|Polycythaemia Vera|Polycythemia Rubra Vera	A chronic myeloproliferative disorder characterized by an increased red blood cell production.  Excessive proliferation of the myeloid lineage is observed as well.  The major symptoms are related to hypertension or to vascular abnormalities caused by the increased red cell mass.  The cause is unknown.  With currently available treatment, the median survival exceeds 10 years.  (WHO, 2001) -- 2003
C3337	Fibroepithelial_Polyp	Polyp	Fibroepithelial Polyp
C3338	Polyploidy	Numerical_Chromosome_Aberration	Polyploidy
C3339	Familial_Adenomatous_Polyposis	Hereditary_Neoplastic_Syndrome|Multiple_Adenomatous_Polyps	Adenomatous Polyposis Coli|APC - Adenomatous Polyposis Coli|FAP|Familial Adenomatous Polyposis|Familial Adenomatous Polyposis Coli|Familial Adenomatous Polyposis Syndrome|Hereditary Adenomatous Polyposis Coli|Polyposis Coli|familial adenomatous polyposis|familial polyposis	(pah-li-PO-sis) An inherited condition in which numerous polyps (growths that protrude from mucous membranes) form on the inside walls of the colon and rectum. It increases the risk for colon cancer.
C3340	Polyp	Diseases_and_Disorders	Polyp|polyp	(POL-ip) A growth that protrudes from a mucous membrane.
C3341	Precancerous_Condition	Cancer-Related_Condition	Precancerous Condition|Precancerous State|Premalignant Condition|Premalignant State	(pre-KAN-ser-us) A term used to describe a condition that may (or is likely to) become cancer.
C3342	Prolactin_Secreting_Pituitary_Gland_Adenoma	Pituitary_Gland_Adenoma|Prolactin_Producing_Pituitary_Gland_Neoplasm	Prolactin Producing Pituitary Gland Adenoma|Lactotroph Adenoma|PRL Producing Pituitary Gland Adenoma|Pituitary Gland Prolactinoma|Pituitary Prolactinoma|Prolactin Producing Adenoma of Pituitary|Prolactin Producing Adenoma of Pituitary Gland|Prolactin Producing Adenoma of the Pituitary|Prolactin Producing Adenoma of the Pituitary Gland|Prolactin Producing Pituitary Adenoma|Prolactin Secreting Adenoma|Prolactin Secreting Adenoma of Pituitary|Prolactin Secreting Adenoma of Pituitary Gland|Prolactin Secreting Adenoma of the Pituitary|Prolactin Secreting Adenoma of the Pituitary Gland|Prolactin Secreting Pituitary Adenoma|Prolactin Secreting Pituitary Gland Adenoma|Prolactinoma|Prolactinoma of Pituitary|Prolactinoma of Pituitary Gland|Prolactinoma of the Pituitary|Prolactinoma of the Pituitary Gland	An adenoma of the anterior lobe of the pituitary gland that produces prolactin.  It is the most common type of pituitary gland adenomas and it is associated with hyperprolactinemia. Clinical manifestations include amenorrhea, galactorrhea, impotence, headache, and visual disturbances. (NCI05)
C3343	Prostate_Neoplasm	Male_Reproductive_System_Neoplasm|Prostate_Disorder	Prostate Neoplasm|Neoplasm of Prostate|Neoplasm of the Prostate|Prostate Tumor|Tumor of Prostate|Tumor of the Prostate	A benign or malignant tumor involving the prostate gland. -- 2003
C3344	Pruritus	Integumentary_System_Signs_and_Symptoms	Pruritus|Itching	An intense itching sensation.
C3345	Pseudomyxoma_Peritonei	Abdominal_Carcinomatosis|Metastatic_Adenocarcinoma|Metastatic_Neoplasm_to_the_Peritoneum|Mucinous_Adenocarcinoma	Pseudomyxoma Peritonei|Gelatinous Ascites|Mucinous Ascites|Myxoma Peritonei|Peritoneal Cavity Pseudomyxoma Peritonei|Well Differentiated Peritoneal Mucinous Adenocarcinoma|pseudomyxoma peritonei	(SOO-doe-mix-O-ma PAIR-ih-TOE-nee-I) A build-up of mucus in the peritoneal cavity. The mucus may come from ruptured ovarian cysts, the appendix, or from other abdominal tissues, and mucus-secreting cells may attach to the peritoneal lining and continue to secrete mucus.
C3346	Psoriasis	Dermatitis	Psoriasis|psoriasis	A chronic disease of the skin marked by red patches covered with white scales.
C3347	Sexual_Dysfunction	Sexual_Dysfunction_and_Infertility	Sexual Dysfunction
C3348	Emphysema	Chronic_Obstructive_Airways_Disease	Emphysema|EMPHY	A subcategory of chronic obstructive pulmonary disease (COPD).  It occurs in people who smoke and suffer from chronic bronchitis.  It is characterized by inflation of the alveoli, alveolar wall damage, and reduction in the number of alveoli, resulting in difficulty breathing.  Alveoli are the vital lung structures where the transfer of oxygen and carbon dioxide takes place. -- 2004
C3349	Radiation-Induced_Dermatitis	Dermatitis|Radiation-Induced_Abnormalities	Radiation-Induced Dermatitis
C3350	Rectal_Neoplasm	Colorectal_Neoplasm	Rectal Neoplasm|Neoplasm of Rectum|Neoplasm of the Rectum|Rectal Tumor|Tumor of Rectum|Tumor of the Rectum	Either benign or malignant growth of tissue in rectum, the terminal portion of the digestive tube.
C3351	Rectal_Polyp	Gastrointestinal_Polyp	Rectal Polyp|Polyp of Rectum|Polyp of the Rectum	This is a descriptive term referring of a mass of tissue that bulges or projects into the lumen of the rectum.  The mass is macroscopically visible and may either have a broad base attachment to the rectal wall, or be on a pedunculated stalk.  These may be benign or malignant.
C3352	Recurrence	Conceptual_Entities	Recurrence|RECUR|recur|recurrence	Happening again (especially at regular intervals).
C3353	Adult_Respiratory_Distress_Syndrome	Respiratory_Distress_Syndrome	Adult Respiratory Distress Syndrome|Adult RDS	fulminant pulmonary interstitial and alveolar edema resulting from diffuse infection, shock, or trauma of the lungs.
C3354	Respiratory_Syncytial_Virus_Infection	Viral_Respiratory_Tract_Infection	Respiratory Syncytial Virus Infection	infection with respiratory syncytial virus, an RNA virus of the genus Pneumovirus, in the family Paramyxoviridae, with a tendency to form syncytia in tissue culture, that causes minor respiratory infection with rhinitis and cough in adults, but is capable of causing severe bronchitis and bronchopneumonia in young children; first isolated from chimpanzees with respiratory disease. SYN chimpanzee coryza agent, Rs virus.  It is a disease associated with HIV infection.
C3355	Respiratory_Tract_Neoplasm	Neoplasm_by_Site|Respiratory_Disorder	Respiratory Tract Neoplasm|Neoplasm of Respiratory Tract|Neoplasm of the Respiratory Tract|Respiratory Tract Tumor|Tumor of Respiratory Tract|Tumor of the Respiratory Tract	Abnormal growth in the respiratory tract
C3356	Solitary_Reticulohistiocytoma	Benign_Cutaneous_Fibrohistiocytic_Neoplasm	Solitary Reticulohistiocytoma|Reticulohistiocytic Granuloma	A rare cutaneous tumor composed of eosinophilic histiocytes, which are often multinucleated.  The lesions are yellow-brown papules affecting any part of the body.  Patients are usually adult men.  The prognosis is excellent. -- 2003
C3357	Retroperitoneal_Neoplasm	Peritoneal_and_Retroperitoneal_Neoplasms|Retroperitoneal_Disorder	Retroperitoneal Neoplasm	Benign and malignant neoplasms which arise from, or occur in, the walls and/or cavities of the abdomen, pelvis, and retroperitoneal space.
C3358	Rhabdomyoma	Benign_Muscle_Neoplasm	Rhabdomyoma	A benign lesion of the striated muscle.  It can occur in the head and neck and the vagina.  Simple excision is curative. --2003
C3359	Rhabdomyosarcoma	Infrequent_Neoplasm|Malignant_Skeletal_Muscle_Neoplasm|Sarcoma_NCI_Grade_3	Rhabdomyosarcoma|rhabdomyosarcoma	A malignant tumor of muscle tissue.
C3360	Supernumerary_Circular_Chromosome	Chromosomal_Aberration	Supernumerary Circular Chromosome|Ring Chromosome|r
C3361	Salivary_Gland_Neoplasm	Head_and_Neck_Neoplasm|Salivary_Gland_Disorder	Salivary Gland Neoplasm|Neoplasm of Salivary Gland|Neoplasm of the Salivary Gland|Salivary Gland Tumor|Tumor of Salivary Gland|Tumor of the Salivary Gland
C3362	Schizophrenia	Cognitive_Disturbance	Schizophrenia	class of psychoses with disturbance mainly of cognition (content and form of thought, perception, sense of self versus external world, volition) and psychomotor function, rather than affect.
C3363	Sebaceous_Neoplasm	Skin_Appendage_Neoplasm	Sebaceous Gland Neoplasm|Sebaceous Gland Tumor|Sebaceous Neoplasm|Sebaceous Tumor
C3364	Septicemia	Bacterial_Infection	Septicemia|Sepsis|sepsis|septicemia	(SEP-sis) The presence of bacteria or their toxins in the blood or tissues.
C3365	Sexually_Transmitted_Disorder	Infectious_Disorder	Sexually Transmitted Disorder|STD|Sexually Transmitted Disease	A disorder acquired through sexual contact. --2004
C3366	Sezary_Syndrome	Aggressive_Non-Hodgkin_s_Lymphoma|Leukemic_Phase_of_Lymphoma|Mycosis_Fungoides_and_Sezary_Syndrome	Sezary Syndrome|Sezary syndrome|Sezary's Disease	A form of cutaneous T-cell lymphoma, a cancerous disease that affects the skin.
C3367	Finding	Diseases_Disorders_and_Findings	Finding|Diagnostic Findings|FNG|Signs and Symptoms	The result of an examination or inquiry.
C3368	Gastrointestinal_System_Signs_and_Symptoms	Gastrointestinal_System_Finding|Symptom	Gastrointestinal System Signs and Symptoms
C3369	Silicosis	Pneumoconiosis	Silicosis
C3370	Vocal_Cord_Nodule	Laryngeal_Disorder	Vocal Cord Nodule|Nodule of Vocal Cord|Nodule of the Vocal Cord|Singers' Node|Singers' Nodule
C3371	Skin_Disorder	Disorder_by_Site	Skin Disorder|Cutaneous Disorder|Skin Diseases and Manifestations
C3372	Skin_Neoplasm	Neoplasm_by_Site|Skin_Disorder	Skin Neoplasm|Neoplasm of Skin|Neoplasm of the Skin|Skin Neoplasms|Skin Tumor|Tumor of Skin|Tumor of the Skin	A benign or malignant tumor involving the skin -- 2003
C3373	Skin_Nodule	Integumentary_System_Signs_and_Symptoms	Skin Nodule|Cutaneous Nodule|Nodule of Skin|Nodule of the Skin
C3374	Skin_Tag	Fibroepithelial_Polyp|Reactive_Cutaneous_Fibrous_Lesions	Skin Tag|Acrochordon|Cutaneous Fibroepithelial Polyp|Cutaneous Tag|Fibroepithelial Polyp of Skin|Fibroepithelial Polyp of the Skin
C3375	Skull_Neoplasm	Head_and_Neck_Neoplasm|Skull_Disorder	Skull Neoplasm|Neoplasm of Skull|Neoplasm of the Skull|Neoplasms of Skull|Neoplasms of the Skull|Skull Neoplasms|Skull Tumor|Skull Tumors|Tumor of Skull|Tumor of the Skull|Tumors of Skull|Tumors of the Skull
C3376	Sleep_Disorder	Psychiatric_Disorder	Sleep Disorder|Sleep Disturbance	A change from the patient's baseline sleeping pattern, either an increase or a decrease in the number of hours slept. This can also refer to alterations in the stages of sleep.
C3377	Soft_Tissue_Neoplasm	Mesenchymal_Cell_Neoplasm|Soft_Tissue_Disorder	Soft Tissue Neoplasm|Neoplasm of Soft Tissue|Neoplasm of the Soft Tissue|Soft Tissue Tumor|Soft Tissue Tumors|Tumor of Soft Tissue|Tumor of the Soft Tissue	A benign or malignant tumor that arises from mesenchymal cells in extra skeletal sites.  The most common types are lipomatous (fatty), vascular, smooth muscle, fibrous, and fibrohistiocytic neoplasms. -- 2003
C3378	Solitary_Breast_Cyst	Breast_Cyst	Solitary Breast Cyst|Solitary Cyst of Breast|Solitary Cyst of the Breast
C3379	Delta_Cell_Somatostatin_Producing_Neoplasm	Gastrointestinal_Neuroendocrine_Neoplasm	Somatostatin Producing Tumor|Delta Cell Neoplasm|Delta Cell Tumor|Neoplasm of Delta Cells|Neoplasm of the Delta Cells|Somatostatin Cell Neoplasm|Somatostatin Cell Tumor|Somatostatin Producing Neoplasm|Somatostatinoma|Tumor of Delta Cells|Tumor of the Delta Cells	A rare, usually malignant tumor arizing from delta cells.  This neoplasm secretes large amounts of somatostatin, which may result in a syndrome characterized by diarrhea, steatorrhea, weight loss, and gastric hyposecretion. Sixty percent are found in the pancreas and 40% in the duodenum or jejunum. The peak incidence occurs between 40 and 60 years of age; women are affected more than men by 2:1. --2004
C3380	Spinal_Cord_Compression	Cancer-Related_Condition	Spinal Cord Compression
C3381	Spinal_Cord_Neoplasm	Intraspinal_Neoplasm	Spinal Cord Neoplasm|Neoplasm of Spinal Cord|Neoplasm of the Spinal Cord|Spinal Cord Tumor|Tumor of Spinal Cord|Tumor of the Spinal Cord	Neoplasms that occur within the parenchyma of the spinal cord (i.e. intramedullary tumors).
C3382	Intraspinal_Neoplasm	Central_Nervous_System_Neoplasm	Intraspinal Neoplasm|Intraspinal Neoplasms|Intraspinal Tumor|Neoplasm of Spinal Canal and Spinal Cord|Neoplasm of the Spinal Canal and Spinal Cord|Neoplasms of Spinal Canal and Spinal Cord|Neoplasms of the Spinal Canal and Spinal Cord|Spinal Canal Tumors|Spinal Canal and Spinal Cord Neoplasm|Spinal Canal and Spinal Cord Tumor|Spinal Neoplasms|Spinal Tumors|Tumor of Spinal Canal and Spinal Cord|Tumor of the Spinal Canal and Spinal Cord	Neoplasms that occur within the spinal canal including the spinal cord and surrounding paraspinal spaces.  Neoplasms that occur within the substance of the spinal cord are referred to as intramedullary neoplasms.  Neoplasms that occur in the space between the spinal cord and the dura mater are referred to as extramedullary intradural neoplasms.  Tumors that occur in the spinal canal outside the dura mater are referred to as extradural neoplasms.  This category includes primary and secondary (i.e., metastatic) neoplasms.  (KEV 8-16-99)
C3383	Splenic_Neoplasm	Hematopoietic_System_Neoplasm|Splenic_Disorder	Splenic Neoplasm
C3384	Splenomegaly	Hematopoietic_System_Finding	Splenomegaly|SPLNCTY	Abnormal enlargement of the spleen.
C3385	Erythema_Multiforme_Major	Erythema_Multiforme	Erythema Multiforme Major|Stevens-Johnson Syndrome
C3387	Gastric_Neoplasm	Gastrointestinal_Neoplasm|Stomach_Disorder	Gastric Neoplasm|Gastric Neoplasms|Gastric Tumor|Gastric Tumors|Neoplasm of Stomach|Neoplasm of the Stomach|Stomach Neoplasm|Stomach Neoplasms|Stomach Tumor|Stomach Tumors|Tumor of Stomach|Tumor of the Stomach	Cancerous or non-cancerous tumors of the stomach
C3388	Gastric_Ulcer	Peptic_Ulcer|Stomach_Disorder	Gastric Ulcer
C3389	Post-Traumatic_Stress_Disorder	Anxiety_Disorder	Post-Traumatic Stress Disorder|disorder, post-traumatic stress	acute, chronic, or delayed reactions to traumatic events such as military combat, assault, or natural disaster.
C3390	Cerebrovascular_Accident	Cerebrovascular_Disorder	Cerebrovascular Accident|Stroke	A sudden, nonconvulsive loss of neurologic function due to an ischemic or hemorrhagic intracranial vascular event. In general, cerebrovascular accidents are classified by anatomic location in the brain, vascular distribution, etiology, age of the affected individual, and hemorrhagic vs. nonhemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)
C3391	Sturge-Weber_Syndrome	Hereditary_Neoplastic_Syndrome	Sturge-Weber Syndrome|Encephalotrigeminal Syndrome|Sturge-Weber Disease
C3392	Sublingual_Gland_Neoplasm	Major_Salivary_Gland_Neoplasm	Sublingual Gland Neoplasm|Neoplasm of Sublingual Gland|Neoplasm of the Sublingual Gland|Sublingual Gland Tumor|Tumor of Sublingual Gland|Tumor of the Sublingual Gland
C3393	Submandibular_Gland_Neoplasm	Major_Salivary_Gland_Neoplasm	Submandibular Gland Neoplasm|Neoplasm of Submandibular Gland|Neoplasm of the Submandibular Gland|Submandibular Gland Tumor|Tumor of Submandibular Gland|Tumor of the Submandibular Gland
C3394	Suicide	Personal_Behavior	Suicide	Suicide is the act of ending one's own life. (from Wikipedia)
C3395	Sunburn	Burn|Integumentary_System_Signs_and_Symptoms	Sunburn
C3396	Superior_Vena_Cava_Syndrome	Cancer-Related_Condition|Syndrome	Superior Vena Cava Syndrome|Superior Vena Cava Obstruction|superior vena cava syndrome	A condition in which a tumor presses against the superior vena cava (the large vein that carries blood from the head, neck, arms, and chest to the heart). This pressure blocks blood flow to the heart and may cause coughing, difficulty in breathing, and swelling of the face, neck, and upper arms.
C3397	Supratentorial_Neoplasm	Brain_Neoplasm	Supratentorial Neoplasm|Brain Neoplasms, Supratentorial|Supratentorial Neoplasms|Supratentorial Tumor|Supratentorial Tumors	Benign and malignant neoplasms which arise or occur in within the intracranial cavity above the tentorium cerebelli.  This includes neoplasms within the supratentorial brain and surrounding spaces.
C3398	Sweat_Gland_Neoplasm	Skin_Appendage_Neoplasm	Sweat Gland Neoplasm|Neoplasm of Sweat Gland|Neoplasm of the Sweat Gland|Sweat Gland Neoplasms|Sweat Gland Tumor|Tumor of Sweat Gland|Tumor of the Sweat Gland	Benign or malignant neoplasm involving the sweat gland. --2003
C3399	Swelling	Symptom	Swelling	Enlargement; expansion in size; sign of inflammation
C3400	Synovial_Sarcoma	Malignant_Synovial_Neoplasm|Sarcoma_NCI_Grade_3|Soft_Tissue_Sarcoma	Synovial Sarcoma|synovial sarcoma	A malignant tumor that develops in the synovial membrane of the joints.
C3401	Diffuse_Giant_Cell_Tumor_of_Tendon_Sheath	Benign_Synovial_Neoplasm|Giant_Cell_Tumor_of_Tendon_Sheath	Diffuse Giant Cell Tumor of Tendon Sheath|Diffuse Giant Cell Neoplasm of Tendon Sheath|Diffuse Giant Cell Neoplasm of Tenosynovium|Diffuse Giant Cell Neoplasm of the Tenosynovium|Diffuse Giant Cell Tumor of Tenosynovium|Diffuse Giant Cell Tumor of the Tenosynovium|Diffuse Tenosynovial Giant Cell Neoplasm|Diffuse Tenosynovial Giant Cell Tumor|Pigmented Villonodular Synovitis
C3402	Giant_Cell_Tumor_of_Tendon_Sheath	Giant_Cell_Tumor|Synovial_Neoplasm	Giant Cell Tumor of Tendon Sheath|Giant Cell Neoplasm of Tendon Sheath|Giant Cell Neoplasm of Tenosynovium|Giant Cell Neoplasm of the Tenosynovium|Giant Cell Tumor of Tenosynovium|Giant Cell Tumor of the Tenosynovium|Tendon Sheath Giant Cell Neoplasm|Tendon Sheath Giant Cell Tumor|Tenosynovial Giant Cell Neoplasm|Tenosynovial Giant Cell Tumor
C3403	Teratoma	Germ_Cell_Neoplasm	Teratoma|teratoma	(ter-a-TOW-ma) A type of germ cell tumor that may contain several different types of tissue, such as hair, muscle, and bone.  Teratomas occur most often in the ovaries in women, the testicles in men, and the tailbone in children.  Not all teratomas are malignant.
C3404	Testicular_Neoplasm	Male_Reproductive_System_Neoplasm|Testicular_Disorder	Testicular Neoplasm|Neoplasm of Testis|Neoplasm of the Testis|Testicular Tumor|Tumor of Testis|Tumor of the Testis	Benign or malignant neoplasm involving the testis.
C3405	Thecoma	Thecoma-Fibroma_Group_Ovarian_Tumor	Ovarian Thecoma|Ovarian Theca Cell Neoplasm|Ovarian Theca Cell Tumor|Theca Cell Neoplasm of Ovary|Theca Cell Neoplasm of the Ovary|Theca Cell Tumor of Ovary|Theca Cell Tumor of the Ovary|Thecoma of Ovary|Thecoma of the Ovary
C3406	Thoracic_Neoplasm	Neoplasm_by_Site|Thoracic_Disorder	Thoracic Neoplasm|Neoplasm of Thorax|Neoplasm of the Thorax|Thoracic Neoplasms|Thoracic Tumor|Tumor of Thorax|Tumor of the Thorax
C3407	Essential_Thrombocythemia	Chronic_Myeloproliferative_Disorder|Megakaryocytic_Neoplasm	Essential Thrombocythemia|Essential Thrombocytemia|Essential Thrombocytosis|Idiopathic Thrombocythemia|Primary Thrombocythemia|Primary Thrombocytosis|essential thrombocythemia|essential thrombocytosis	A chronic myeloproliferative disorder that involves primarily the megakaryocytic lineage and it is characterized by sustained thrombocytosis in the blood, increased numbers of large, mature megakaryocytes in the bone marrow, and episodes of thrombosis and/or hemorrhage.  The cause is unknown.  Median survival times of 10-15 years are commonly reported.  (WHO, 2001) -- 2003
C3408	Thrombocytopenia	Cytopenia	Thrombocytopenia|thrombocytopenia	A condition in which there is an abnormally small number of platelets in the circulating blood.
C3410	Thrombophlebitis	Non-Neoplastic_Vascular_Disorder	Thrombophlebitis|thrombophlebitis	(throm-bo-fleh-BY-tis) Inflammation of a vein that occurs when a blood clot forms.
C3411	Thymoma	Thymus_Epithelial_Neoplasm	Thymoma|thymoma	A neoplasm arising from the epithelial cells of the thymus.  Although thymomas are usually encapsulated tumors, they may invade the capsule and infiltrate the surrounding tissues or even metastasize to distant anatomic sites.  The following morphologic subtypes are currently recognized: type A, type B, type AB, metaplastic, micronodular, microscopic, and sclerosing thymoma.  Thymomas type B are further subdivided into types B1, B2, and B3.  Thymoma type B3 usually has the most aggressive clinical course.  --2003
C3412	Thymic_Neoplasm	Thymus_Disorder	Thymic Neoplasm|Neoplasm of Thymus|Neoplasm of the Thymus|Thymic Tumor|Thymus Neoplasm|Thymus Tumor|Tumor of Thymus|Tumor of the Thymus
C3414	Thyroid_Neoplasm	Neck_Neoplasm|Thyroid_Gland_Disorder	Thyroid Gland Neoplasm|Neoplasm of Thyroid|Neoplasm of Thyroid Gland|Neoplasm of the Thyroid|Neoplasm of the Thyroid Gland|Thyroid Gland Tumor|Thyroid Neoplasm|Thyroid Neoplasms|Thyroid Tumor|Tumor of Thyroid|Tumor of Thyroid Gland|Tumor of the Thyroid|Tumor of the Thyroid Gland	A benign or malignant neoplasm affecting the thyroid gland. --2005
C3415	Thyroid_Nodule	Thyroid_Gland_Disorder	Thyroid Gland Nodule|Nodule of Thyroid|Nodule of Thyroid Gland|Nodule of the Thyroid|Nodule of the Thyroid Gland|Thyroid Nodule
C3416	Tongue_Neoplasm	Oral_Cavity_Neoplasm	Tongue Neoplasm|Neoplasm of Tongue|Neoplasm of the Tongue|Tongue Tumor|Tumor of Tongue|Tumor of the Tongue	Abnormal growth of the cells that comprise the tongue.
C3417	Tonsillar_Neoplasm	Oropharyngeal_Neoplasm	Tonsillar Neoplasm|Neoplasm of Tonsil|Neoplasm of the Tonsil|Tonsil Neoplasm|Tonsil Tumor|Tonsillar Neoplasms|Tonsillar Tumor|Tumor of Tonsil|Tumor of the Tonsil
C3418	Toxoplasmosis	Parasitic_Infection	Toxoplasmosis
C3419	Tracheal_Neoplasm	Respiratory_Tract_Neoplasm|Tracheal_Disorder	Tracheal Neoplasm|Neoplasm of Trachea|Neoplasm of the Trachea|Trachea Neoplasm|Trachea Tumor|Tracheal Tumor|Tumor of Trachea|Tumor of the Trachea
C3420	Chromosomal_Translocation	Chromosomal_Rearrangement	Chromosomal Translocation|Chromosome Translocation|t	A genetic exchange where a piece of one chromosome is transfered to another chromosome.
C3421	Trisomy	Numerical_Chromosome_Aberration	Trisomy
C3422	Trophoblastic_Neoplasm	Germ_Cell_Neoplasm	Trophoblastic Tumor|Trophoblastic Neoplasm|Trophoblastic Neoplasms
C3423	Tuberculosis	Mycobacterial_Infection	Tuberculosis	A chronic, recurrent infection caused by the bacterium Mycobacterium tuberculosis. Tuberculosis (TB) may affect almost any tissue or organ of the body with the lungs being the most common site of infection. The clinical stages of TB are primary or initial infection, latent or dormant infection, and recrudescent or adult-type TB. Ninety to 95% of primary TB infections may go unrecognized. Histopathologically, tissue lesions consist of granulomas which usually undergo central caseation necrosis. Local symptoms of TB vary according to the part affected; acute symptoms include hectic fever, sweats, and emaciation; serious complications include granulomatous erosion of pulmonary bronchi associated with hemoptysis. If untreated, progressive TB may be associated with a high degree of mortality. This infection is frequently observed in immunocompromised individuals with AIDS or a history of illicit IV drug use. --2004
C3424	Tuberous_Sclerosis	Hereditary_Neoplastic_Syndrome	Tuberous Sclerosis|Bourneville's Disease	Hereditary disease characterized by seizures, mental retardation, developmental delay, and skin and ocular lesions. First signs usually occur during infancy or childhood but in rare cases may not occur until 2nd or 3rd decade.
C3425	Tumor_Lysis_Syndrome	Cancer-Related_Condition|Syndrome	Tumor Lysis Syndrome	A condition of metabolic abnormalities that result from a spontaneous or therapy-related cytolysis of tumor cells. Tumor lysis syndrome typically occurs in aggressive, rapidly proliferating lymphoproliferative disorders. Burkitt lymphoma and T cell acute lymphoblastic leukemia are commonly associated with this syndrome. Metabolic abnormalities include hyperuricemia, lactic acidosis, hyperkalemia, hyperphosphatemia and hypocalcemia and may result in renal failure, multiple organ failure, and death. --2004
C3426	Ulcer	Injury	Ulcer
C3427	Ureter_Neoplasm	Kidney_and_Ureter_Neoplasm|Ureter_Disorder	Ureter Neoplasm|Neoplasm of Ureter|Neoplasm of the Ureter|Neoplasms of Ureter|Neoplasms of the Ureter|Tumor of Ureter|Tumor of the Ureter|Ureter Tumor|Ureteral Neoplasm|Ureteral Tumor
C3428	Urethra_Neoplasm	Urethra_Disorder|Urinary_Tract_Neoplasm	Urethra Neoplasm|Neoplasm of Urethra|Neoplasm of the Urethra|Neoplasms. Urethra|Tumor of Urethra|Tumor of the Urethra|Tumors. Urethra|Urethra Neoplasms|Urethra Tumor|Urethra Tumors|Urethral Neoplasm|Urethral Neoplasms|Urethral Tumor|Urethral Tumors
C3429	Urinary_Incontinence	Genitourinary_Signs_and_Symptoms|Urinary_Tract_Finding	Urinary Incontinence|Incontinence|incontinence	(in-KAHN-tih-nens) Inability to control the flow of urine from the bladder (urinary incontinence) or the escape of stool from the rectum (fecal incontinence).
C3430	Urinary_Tract_Disorder	Disorder_by_Site	Urinary Tract Disorder|Urinary Tract Disease|Urologic Disorder|Urological Disorders	Disorders of any part of the urologic system
C3431	Urinary_Tract_Neoplasm	Neoplasm_by_Site|Urinary_Tract_Disorder	Urinary Tract Neoplasm|Neoplasm of Urinary System|Neoplasm of Urinary Tract|Neoplasm of the Urinary System|Neoplasm of the Urinary Tract|Tumor of Urinary System|Tumor of Urinary Tract|Tumor of the Urinary System|Tumor of the Urinary Tract|Urinary System Neoplasm|Urinary System Tumor|Urinary Tract Tumor	Benign or malignant neoplasm involving the urinary tract. --2003
C3432	Urticaria	Dermatitis	Urticaria	An itchy skin eruption characterized by weals with pale interiors and well-defined red margins; usually the result of an allergic response to insect bites or food or drugs.
C3433	Urticaria_Pigmentosa_Maculopapular_Cutaneous_Mastocytosis	Pure_Cutaneous_Mastocytosis	Urticaria Pigmentosa/Maculopapular Cutaneous Mastocytosis|UP/MPCM|Urticaria Pigmentosa	The most frequent form of cutaneous mastocytosis.  In children, the lesions tend to be papular, and are characterized by aggregates of elongated or spindle-shaped mast cells which fill the papillary dermis and extend into the reticular dermis.  In adults, the lesions tend to have fewer mast cells compared to those in children.  The lesions are located most commonly on the trunk, but they can be seen on the extremities, head and neck. (WHO, 2001) -- 2003
C3434	Uterine_Corpus_Leiomyoma	Benign_Uterine_Corpus_Neoplasm|Leiomyoma|Uterine_Corpus_Smooth_Muscle_Neoplasm	Uterine Corpus Leiomyoma|Body of Uterus Fibroid|Body of Uterus Leiomyoma|Corpus Uteri Fibroid|Corpus Uteri Leiomyoma|Fibroid of Body of Uterus|Fibroid of Corpus Uteri|Fibroid of Uterine Body|Fibroid of Uterine Corpus|Fibroid of the Body of Uterus|Fibroid of the Corpus Uteri|Fibroid of the Uterine Body|Fibroid of the Uterine Corpus|Leiomyoma of Body of Uterus|Leiomyoma of Corpus Uteri|Leiomyoma of Uterine Body|Leiomyoma of Uterine Corpus|Leiomyoma of the Body of Uterus|Leiomyoma of the Corpus Uteri|Leiomyoma of the Uterine Body|Leiomyoma of the Uterine Corpus|Uterine Body Fibroid|Uterine Body Leiomyoma|Uterine Corpus Fibroid|Uterine Fibroid
C3435	Uterine_Neoplasm	Female_Reproductive_System_Neoplasm|Uterine_Disorder	Uterine Neoplasm|Neoplasm of Uterus|Neoplasm of the Uterus|Tumor of Uterus|Tumor of the Uterus|Uterine Neoplasms|Uterine Tumor	Abnormal growth in the tissues of uterus, either cancerous or non-cancerous.
C3436	Uveal_Neoplasm	Eye_Neoplasm|Uveal_Disorder	Uveal Neoplasm|Neoplasm of Uvea|Neoplasm of the Uvea|Tumor of Uvea|Tumor of the Uvea|Uvea Neoplasm|Uvea Tumor|Uveal Tumor
C3437	Vaginal_Neoplasm	Female_Reproductive_System_Neoplasm|Vaginal_Disorder	Vaginal Neoplasm|Neoplasm of Vagina|Neoplasm of the Vagina|Tumor of Vagina|Tumor of the Vagina|Vagina Neoplasm|Vagina Tumor|Vaginal Tumor
C3438	Vascular_Hamartoma	Mesenchymal_Hamartoma	Vascular Hamartoma
C3439	Viral_Infection	Infectious_Disorder	Viral Infection	Any disease caused by a virus.
C3440	Vocal_Cord_Polyp	Non-Neoplastic_Laryngeal_Disorder|Polyp	Vocal Cord Polyp|Polyp of Vocal Cord|Polyp of the Vocal Cord
C3441	Voice_Disorder	Non-Neoplastic_Laryngeal_Disorder	Voice Disorder
C3442	Vomiting	Nausea_and_Vomiting	Vomiting|Emesis|VOMT|emesis	The reflex act of ejecting the contents of the stomach through the mouth.
C3443	Vulvar_Neoplasm	Female_Reproductive_System_Neoplasm|Vulvar_Disorder	Vulvar Neoplasm|Neoplasm of Vulva|Neoplasm of the Vulva|Tumor of Vulva|Tumor of the Vulva|Vulva Neoplasm|Vulva Tumor|Vulvar Tumor	A neoplasm involving the cells of the vulva, i.e. the labia majora the labia minora and the clitori. This neoplasm can be either benign or malignant.
C3444	Wegener_s_Granulomatosis	Vasculitis	Wegener's Granulomatosis
C3445	Weight_Loss	Weight_Change	Weight Loss|WT-LOSS	A reduction in overall body mass.
C3446	Idiopathic_Thrombocytopenic_Purpura	Thrombocytopenic_Purpura	Idiopathic Thrombocytopenic Purpura
C3447	Werner_Syndrome	DNA_Repair_Disorder|Hereditary_Neoplastic_Syndrome	Werner Syndrome|Adult Progeria|WS|Werner's Syndrome	Werner Syndrome (WS) is an inherited disease characterized by an early onset of atherosclerosis, osteoporosis, diabetes mellitus, and cancers of non-epithelial cell origin. Cultured cells from WS patients also present a shortened replicative lifespan and increased genetic instability. The genomic instability of WS cells is manifested at the cytogenetic level in the form of chromosome breaks and translocations, and at the molecular level predominately by multiple, large DNA deletions. (J. Biol. Chem., 273(51):34139-34144, 1998)
C3448	Wiskott-Aldrich_Syndrome	Congenital_Combined_Immunodeficiency|Hereditary_Neoplastic_Syndrome	Wiskott-Aldrich Syndrome	A rare, X-linked immunodeficiency syndrome characterized by eczema, thrombocytopenia, and recurrent pyogenic infection. It is seen exclusively in young boys. Typically, IgM levels are low and IgA and IgE levels are elevated. Lymphoreticular malignancies are common.
C3451	Juvenile_Xanthogranuloma	Xanthogranuloma	Juvenile Xanthogranuloma	A benign fibrohistiocytic neoplasm that occurs during childhood; it is distinct from Langerhans cell histiocytosis.  The lesions usually develop during infancy, and are characterized by regressing cutaneous nodules (most often in the head and neck) sometimes associated with deep soft tissues nodules.  The prognosis is excellent. -- 2003
C3452	Xeroderma_Pigmentosum	Cutaneous_Precancerous_Condition|DNA_Repair_Disorder	Xeroderma Pigmentosum|Angioma Pigmentosum Atrophicum|Atrophoderma Pigmentosum|Kaposi Dermatosis|Kaposi Disease|Melanosis Lenticularis Progressiva|Pigmented Epitheliomatosis|Xeroderma Pigmentosum Syndrome|Xeroderma of Kaposi|xeroderma pigmentosum	A genetic condition characterized by a sensitivity to all sources of ultraviolet radiation.
C3453	Zollinger_Ellison_Syndrome	Endocrine_Syndrome	Zollinger Ellison Syndrome|Zollinger-Ellison syndrome	A disorder in which tumors of the pancreatic islet cells produce large amounts of gastrin (a hormone), leading to excess acid in the stomach and, possibly, a peptic ulcer (ulcer of the stomach or the upper part of the small intestine).
C3455	Arachnoid_Cyst	Meningeal_Cyst	Arachnoid Cyst|Leptomeningeal Cyst
C3456	Infantile_Digital_Fibromatosis	Benign_Cutaneous_Fibrous_Neoplasm	Infantile Digital Fibromatosis|Digital Fibrous Tumor of Reye|Reye's Tumor
C3457	B-Cell_Non-Hodgkin_s_Lymphoma	B-Cell_Lymphocytic_Neoplasm|Non-Hodgkin_s_Lymphoma	B-Cell Non-Hodgkin's Lymphoma|B Cell Non-Hodgkins Lymphoma|B Cell NonHodgkin's Lymphoma|B Cell NonHodgkins Lymphoma|B-Cell Non-Hodgkins Lymphoma|B-Cell NonHodgkin's Lymphoma|B-Cell NonHodgkins Lymphoma|Lymphomas NonHodgkin's B-Cell|Non-Hodgkin's B-Cell Lymphoma|NonHodgkin's Lymphoma B-Cell	The most common type of non-Hodgkin's lymphoma.  It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003
C3458	High-Grade_Lymphoma	Lymphoma_by_Working_Formulation_Antiquated	High Grade Lymphoma|high-grade lymphomas	Includes large cell, immunoblastic, lymphoblastic, and small noncleaved cell lymphomas. These lymphomas grow quickly but have a better response to anticancer drugs than that seen with low-grade lymphomas.
C3459	Intermediate-Grade_Lymphoma	Lymphoma_by_Working_Formulation_Antiquated	Intermediate Grade Lymphoma|intermediate-grade lymphomas	Includes diffuse, small, cleaved cell lymphoma and diffuse, large, noncleaved cell lymphoma. These are more aggressive than low-grade lymphomas, but they respond better to anticancer drugs.
C3460	Grade_3_Follicular_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|Follicular_Lymphoma	Grade 3 Follicular Lymphoma|Follicular Large Cell Lymphoma|Grade III Follicular Large Cell Lymphoma|Grade III Follicular Lymphoma|Nodular Histiocytic Lymphoma|follicular large cell lymphoma	(foll-IK-yew-lar large cell lim-FO-ma) A rare type of non-Hodgkin's lymphoma (cancer of the lymphatic system) with large cells that look cleaved (split) or non-cleaved under the microscope.  It is an indolent (slow-growing) type of lymphoma.
C3461	Immunoblastic_Lymphoma	Diffuse_Large_B-Cell_Lymphoma	Immunoblastic Lymphoma
C3462	Low-Grade_Lymphoma	Lymphoma_by_Working_Formulation_Antiquated	Low Grade Lymphoma|low-grade lymphomas	Lymphomas that tend to grow and spread slowly, including chronic lymphocytic lymphoma and follicular small cleaved cell lymphoma. Also called indolent lymphomas.
C3463	Diffuse_Mixed_Cell_Lymphoma	Mixed_Cell_Lymphoma	Diffuse Mixed Cell Lymphoma|Diffuse Mixed Large and Small Cell Lymphoma
C3464	Adult_Diffuse_Small_Cleaved_Cell_Lymphoma	Malignant_Non-Hodgkin_s_Lymphoma_Cleaved_Cell	Adult Diffuse Small Cleaved Cell Lymphoma|Adult Diffuse Poorly Differentiated Cell Lymphoma
C3465	Grade_1_Follicular_Lymphoma	Follicular_Lymphoma|Indolent_Non-Hodgkin_s_Lymphoma	Grade 1 Follicular Lymphoma|Follicular Small Cleaved Cell Lymphoma|Grade I Follicular Lymphoma|Grade I Follicular Small Cleaved Cell Lymphoma|Poorly Differentiated Nodular Lymphocytic Lymphoma
C3466	T-Cell_Non-Hodgkin_s_Lymphoma	Non-Hodgkin_s_Lymphoma|T-Cell_and_NK-Cell_Neoplasm	T-Cell Non-Hodgkin's Lymphoma|Lymphomas NonHodgkin's T-Cell|Non-Hodgkin's T-Cell Lymphoma|T Cell Lymphoma|T Cell Non-Hodgkins Lymphoma|T Cell NonHodgkin's Lymphoma|T Cell NonHodgkins Lymphoma|T-Cell Lymphoma|T-Cell Non-Hodgkins Lymphoma|T-Cell NonHodgkin's Lymphoma|T-Cell NonHodgkins Lymphoma|T-Cell and NK-Cell Non-Hodgkin's Lymphoma|T-cell lymphoma	(lim-FO-ma) A disease in which certain cells of the lymph system (called T lymphocytes) become cancerous.
C3467	Cutaneous_T-Cell_Lymphoma	Cutaneous_Lymphoma|Cutaneous_Mature_T-Cell_and_NK-Cell_Neoplasm|Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Cutaneous T-Cell Non-Hodgkin's Lymphoma|CTCL|Cutaneous T Cell Lymphoma|Primary Cutaneous T-Cell Non-Hodgkin's Lymphoma|Skin T-Cell Non-Hodgkin's Lymphoma|T-Cell Non-Hodgkin's Lymphoma of Skin|T-Cell Non-Hodgkin's Lymphoma of the Skin|cutaneous T-cell lymphoma	A category of T-cell non-Hodgkin's lymphomas that involve the skin.  The major representatives are mycosis fungoides and primary cutaneous anaplastic large cell lymphoma.  (WHO, 2001) -- 2003
C3468	Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Mature_T-Cell_and_NK-Cell_Neoplasm|T-Cell_Non-Hodgkin_s_Lymphoma	Mature T-Cell and NK-Cell Non-Hodgkin's Lymphoma|Mature T-Cell Non-Hodgkin's Lymphoma|Mature T-Cell and NK-Cell Lymphoma|Mature T-and NK-Cell Lymphoma|PTCL|Peripheral T-Cell Lymphoma	This type of lymphoma is not frequently seen in the western hemisphere.  Clinically, with the exception of anaplastic large cell lymphoma, mature T-and NK-cell lymphomas are among the most aggressive of all hematopoietic neoplasms.  Representative disease entities include mycosis fungoides, angioimmunoblastic T-cell lymphoma, hepatosplenic T-cell lymphoma, and anaplastic large cell lymphoma.
C3469	Palmar_Fibromatosis	Benign_Cutaneous_Fibrous_Neoplasm|Superficial_Fibromatosis	Palmar Fibromatosis|Dupuytren's Contracture
C3470	Granuloma_Annulare	Non-Neoplastic_Skin_Disorder	Granuloma Annulare
C3471	AIDS-Related_Lymphoma	AIDS-Related_Malignant_Neoplasm|Virus-Related_Lymphoma	AIDS-Related Lymphoma|AIDS Lymphoma|AIDS Related Lymphoma|HIV Associated Lymphoma|Lymphoma AIDS Related|Lymphoma, AIDS-Related	An aggressive lymphoma that develops in HIV-positive patients.  There is a significant increase in the incidence of lymphomas associated with the AIDS epidemic in the last two decades.  These lymphomas are usually extranodal, most often express a B-cell phenotype and morphologically are classified as Burkitt's, diffuse large B-cell, and Hodgkin's lymphomas.  The prognosis is closely related to the severity of immunodeficiency.
C3472	Severe_Combined_Immunodeficiency	Congenital_Combined_Immunodeficiency	Severe Combined Immunodeficiency|SCID	X-linked or autosomal recessive disorder characterized by defects of both humoral and cell mediated immunity, resulting in low or absent antibody levels, leukopenia, marked susceptibility to infections, and early death.--2004
C3473	Choroid_Plexus_Neoplasm	Epithelial_Neoplasm|Intraventricular_Brain_Neoplasm	Choroid Plexus Neoplasm|Choroid Plexus Tumor|Neoplasm of Choroid Plexus|Neoplasm of the Choroid Plexus|Tumor of Choroid Plexus|Tumor of the Choroid Plexus|choroid plexus tumor	A rare type of cancer that occurs in the ventricles of the brain. It usually occurs in children younger than 2 years.
C3474	Granular_Cell_Tumor	Neoplasm_of_Uncertain_Histogenesis	Granular Cell Tumor|Granular Cell Myoblastoma|Granular Cell Neoplasm|Neoplasm of Granular Cell|Neoplasm of the Granular Cell|Tumor of Granular Cell|Tumor of the Granular Cell
C3475	Bone_Remodeling	Musculoskeletal_Process	Bone Remodeling	A concomitant process in which old bone is resorbed and new bone is formed. Bone remodeling occurs primarily in bone and involves two types of cells, osteoblasts and osteoclasts. Osteoblasts synthesize bone matrix and form new bone while osteoclasts digest mineral matrix and old bone.
C3476	Li-Fraumeni_Syndrome	Hereditary_Neoplastic_Syndrome	Li-Fraumeni Syndrome|Li-Fraumeni Familiar Cancer Susceptibility Syndrome|Li-Fraumeni syndrome	A rare, inherited predisposition to multiple cancers, caused by an alteration in the p53 tumor suppressor gene.
C3477	Bacillary_Angiomatosis	Reactive_Vascular_Proliferation	Bacillary Angiomatosis|Bacillary Epithelioid Angiomatosis|Epithelioid Angiomatosis
C3478	Essential_Hypertension	Hypertension	Essential Hypertension|Primary Hypertension	hypertension occurring without preexisting renal disease or known organic cause.
C3479	Addiction	Psychiatric_Disorder	Addiction|addiction	Uncontrollable craving, seeking, and use of a substance such as a drug or alcohol.
C3480	Lobular_Capillary_Hemangioma	Capillary_Hemangioma|Common_Connective_and_Soft_Tissue_Neoplasm	Lobular Hemangioma|Granulation Tissue-Type Hemangioma|Granuloma Pyogenicum|Granuloma Telangiecticum|Granulomata Pyogenicum|Hemangiomatous Granulation Tissue|Pyogenic Granuloma
C3481	Spider_Nevus	Vascular_Ectasia	Nevus Araneus|Arterial Spider|Spider Angioma|Spider Nevus|Spider Telangiectasia|Spider Telangiectasis|Stellate Telangiectasis|Telangiectatic Nevus|Vascular Spider
C3482	Metastatic_Carcinoma	Carcinoma|Metastatic_Malignant_Neoplasm	Metastatic Carcinoma
C3483	Chronic_Leukemia	Leukemia	Chronic Leukemia|chronic leukemia	(KRAHN-ik) A slowly progressing cancer of the blood-forming tissues.
C3484	Breast_Adenosis	Non-Neoplastic_Breast_Disorder	Breast Adenosis|Adenosis of Breast|Adenosis of the Breast
C3485	Atonic_Epilepsy	Epilepsy	Atonic Epilepsy
C3486	Epithelioid_Cell_Type_Gastrointestinal_Stromal_Tumor	Gastrointestinal_Stromal_Tumor	Epithelioid Cell Type Gastrointestinal Stromal Tumor|Epithelioid Cell Type GIST|Leiomyoblastoma|Stout's Leiomyoblastoma	A rare tumor arising from smooth muscle.  The majority arise in the stomach, however the colon, bladder, vulva, and other sites may give rise to this neoplasm.  Benign and malignant variants occur.
C3487	Therapy-Related_Neoplasm	Neoplasm_by_Cause	Therapy-Related Neoplasm|Therapy Related Neoplasm|Therapy Related Tumor
C3488	WDHA_Syndrome	Endocrine_Syndrome	WDHA Syndrome|Islet Cell WDHA Syndrome|Pancreatic Cholera|Pancreatic WDHA Syndrome|Verner Morrison Syndrome|WDHH|Watery Diarrhea Syndrome|Watery Diarrhea with Hypokalemic Alkalosis|Watery Diarrhea, Hypokalemia, and Achlorhydria Syndrome
C3489	Benign_Penile_Neoplasm	Benign_Male_Reproductive_System_Neoplasm|Penile_Neoplasm	Benign Penile Neoplasm|Benign Neoplasm of Penis|Benign Neoplasm of the Penis|Benign Penile Tumor|Benign Tumor of Penis|Benign Tumor of the Penis
C3490	Lip_Carcinoma	Lip_and_Oral_Cavity_Carcinoma|Malignant_Lip_Neoplasm	Lip Carcinoma|Carcinoma of Lip|Carcinoma of the Lip	Abnormal growth, with malignant characteristics, of the cells that comprise the lips of the mouth.
C3491	Cecum_Carcinoma	Colon_Carcinoma|Malignant_Cecum_Neoplasm	Cecum Carcinoma|Carcinoma of Cecum|Carcinoma of the Cecum|Cecal Cancer
C3492	Enzyme_Deficiency	Abnormal_Blood_and_Hematology_Test_Result	Enzyme Deficiency	abnormal and/or pathologic state usually due to mutations in structural genes for enzyme polypeptides, manifesting as metabolic abnormalities.
C3493	Squamous_Cell_Lung_Carcinoma	Lung_Carcinoma|Squamous_Cell_Carcinoma	Squamous Cell Lung Carcinoma|Epidermoid Cell Carcinoma of Lung|Epidermoid Cell Carcinoma of the Lung|Epidermoid Cell Lung Carcinoma|Squamous Cell Carcinoma of Lung|Squamous Cell Carcinoma of the Lung	A carcinoma arising from malignant squamous bronchial epithelial cells and characterized by the presence of keratinization and/or intercellular bridges.  Cigarette smoking and arsenic exposure are strongly associated with squamous cell lung carcinoma. (NCI05)
C3494	Bronchial_Adenoma	Lung_Adenoma|Papillary_Epithelial_Neoplasm	Lung Papillary Adenoma|Adenoma of Bronchus|Adenoma of the Bronchus|Bronchial Adenoma|Papillary Adenoma of Type II Pneumocytes|Peripheral Papillary Tumor of Type II Pneumocytes|Type II Pneumocyte Adenoma
C3495	Colon_Villous_Adenoma	Colonic_Adenoma|Colorectal_Villous_Adenoma	Colon Villous Adenoma|Colonic Villous Adenoma|Villous Adenoma of Colon|Villous Adenoma of the Colon
C3496	Hypercalcemia_of_Malignancy	Hypercalcemia	Hypercalcemia of Malignancy	Hypercalcemia generally develops as a late complication of malignancy; its appearance has grave prognostic significance. It remains unclear, however, whether death is associated with hypercalcemic crisis (uncontrolled or recurrent progressive hypercalcemia) or with advanced disease.  Symptoms include central nervous system impairment such as as delirium with prominent symptoms of personality change, cognitive dysfunction, disorientation, incoherent speech, and psychotic symptoms such as hallucinations and delusions, smooth muscle hypotonicity, and altered cardiovascular function.
C3497	Lung_Hamartoma	Benign_Lung_Neoplasm|Chondroid_Hamartoma	Lung Hamartoma|Hamartoma of Lung|Hamartoma of the Lung|Lung Chondroid Hamartoma|Pulmonary Hamartoma
C3498	Ovarian_Fibroma	Benign_Ovarian_Sex_Cord-Stromal_Tumor|Fibroma|Thecoma-Fibroma_Group_Ovarian_Tumor	Ovarian Fibroma|Fibroma of Ovary|Fibroma of the Ovary
C3499	Atrial_Myxoma	Benign_Atrial_Neoplasm|Endocardial_Myxoma	Atrial Myxoma|Myxoma of Atrium|Myxoma of the Atrium
C3500	Peripheral_Motor_Neuropathy	Neuropathy	Peripheral Motor Neuropathy	Inflammation or degeneration of the peripheral motor nerves. - 2003
C3501	Peripheral_Sensory_Neuropathy	Neuropathy	Peripheral Sensory Neuropathy	Inflammation or degeneration of the sensory nerves. - 2003
C3502	Thyroid_Adenoma	Adenoma|Benign_Endocrine_Neoplasm|Benign_Thyroid_Neoplasm|Thyroid_Nodule	Thyroid Gland Follicular Adenoma|Adenoma of Thyroid|Adenoma of Thyroid Gland|Adenoma of the Thyroid|Adenoma of the Thyroid Gland|Follicular Adenoma|Follicular Adenoma of Thyroid|Follicular Adenoma of Thyroid Gland|Follicular Adenoma of the Thyroid|Follicular Adenoma of the Thyroid Gland|Thyroid Adenoma|Thyroid Follicular Adenoma|Thyroid Gland Adenoma	A benign, encapsulated tumor, arizing from the follicular cells of the thyroid gland. It may be associated with thyroid hormone secretion but it does not have malignant characteristics.
C3503	Hypertensive_Encephalopathy	Encephalopathy|Hypertensive_Crisis	Hypertensive Encephalopathy
C3504	Endometrial_Disorder	Uterine_Disorder	Endometrial Disorder|endometrial disorder	Abnormal cell growth in the endometrium (the lining of the uterus).
C3505	Granulomatous_Dermatitis	Dermatitis	Granulomatous Dermatitis
C3506	Adrenal_Cortex_Hyperplasia	Adrenal_Gland_Hyperplasia	Adrenal Cortical Hyperplasia|Adrenal Cortex Hyperplasia|Adrenocortical Hyperplasia|Hyperplasia of Adrenal Cortex|Hyperplasia of the Adrenal Cortex
C3507	Immune_System_Disorder	Immune_System_and_Related_Disorders	Immune System Disorder|Immune Dysfunction	A disorder resulting from an abnormality in the immune system. -- 2003
C3508	Injection_Site_Reaction	Pathologic_Process	Injection Site Reaction	An intense reaction (usually immunologic) developing at the site of injection
C3509	Genital_Leukoplakia	Leukoplakia	Genital Leukoplakia|Leukoplakia of Genitals|Leukoplakia of the Genitals	A clinical term used to describe hyperkeratotic epithelial white patches of the genital mucous membranes.--2004
C3510	Cutaneous_Melanoma	Malignant_Skin_Neoplasm|Melanocytic_Skin_Neoplasm|Melanoma	Cutaneous Melanoma|Malignant Cutaneous Melanoma|Malignant Melanoma (of Skin), Stage Unspecified|Malignant Melanoma of Skin|Malignant Melanoma of Skin Stage Unspecified|Melanoma of Skin|Melanoma of the Skin|Skin Melanoma|Skin, Melanoma	A malignant neoplasm derived from cells that are capable of forming melanin.
C3511	Degenerated_Uterine_Corpus_Leiomyoma	Uterine_Corpus_Leiomyoma	Uterine Corpus Degenerated Leiomyoma|Degenerated Uterine Fibroid|Uterine Fibroid Degenerated|Uterine Leiomyoma Degenerated
C3512	Lung_Adenocarcinoma	Non-Small_Cell_Adenocarcinoma|Non-Small_Cell_Lung_Carcinoma	Lung Adenocarcinoma|Adenocarcinoma of Lung|Adenocarcinoma of the Lung	A carcinoma characterized by the presence of malignant glandular epithelial cells.  There is a male predilection with a male to female ratio of 2:1.  Usually lung adenocarcinoma is asymptomatic and is identified through screening studies or as an incidental radiologic finding.  If clinical symptoms are present they include shortness of breath, cough, hemoptysis, chest pain, and fever.  Tobacco smoke is a known risk factor. (NCI05)
C3513	Esophageal_Carcinoma	Carcinoma|Malignant_Esophageal_Neoplasm	Esophageal Carcinoma|Cancer of Esophagus|Cancer of the Esophagus|Carcinoma of Esophagus|Carcinoma of the Esophagus|Esophageal Cancer|Esophagus Carcinoma	A malignant epithelial tumor arising from the esophageal mucosa.  Two major histologic types of esophageal carcinoma have been described: squamous cell carcinoma and adenocarcinoma.  This type of cancer is associated with excessive ethanol and cigarette usage.  --2002
C3514	Hypertensive_Retinopathy	Non-Neoplastic_Retinal_Disorder	Hypertensive Retinopathy
C3515	Galactocele	Non-Neoplastic_Breast_Disorder	Galactocele
C3516	Aneurysmal_Bone_Cyst	Non-Neoplastic_Bone_Disorder	Aneurysmal Bone Cyst|Aneurysmal Cyst of Bone|Aneurysmal Cyst of the Bone
C3517	Mixed_Cellularity_Hodgkin_s_Lymphoma	Classical_Hodgkin_s_Lymphoma	Mixed Cellularity Hodgkin's Lymphoma|Hodgkin's Disease Mixed Cellularity|Hodgkin's Lymphoma Mixed Cellularity|MCHL|Mixed Cellularity Hodgkin Lymphoma|Mixed Cellularity Hodgkin's Disease	A subtype of classical Hodgkin's lymphoma with a mixed inflammatory stroma containing Hodgkin's and Reed-Sternberg cells.  (WHO, 2001) -- 2003
C3518	Nodular_Sclerosis_Hodgkin_s_Lymphoma	Classical_Hodgkin_s_Lymphoma	Nodular Sclerosis Hodgkin's Lymphoma|Hodgkin's Nodular Sclerosis|NSHL|Nodular Sclerosis Hodgkin Lymphoma|Nodular Sclerosis Hodgkin's Disease	A subtype of classical Hodgkin's lymphoma characterized by collagen bands surrounding lymphoid nodules. The lymphoid nodules contain lacunar and Reed-Sternberg cells.  Mediastinal involvement occurs in 80% of patients.  The prognosis of nodular sclerosis Hodgkin's lymphoma is slightly better than that of mixed cellularity or lymphocyte depleted subtype. (WHO, 2001) -- 2003
C3519	Atypical_Chronic_Myeloid_Leukemia	Myelodysplastic_Myeloproliferative_Disease	Atypical Chronic Myeloid Leukemia|Atypical CML|Subacute Granulocytic Leukemia|Subacute Myelogenous Leukemia|Subacute Myeloid Leukemia|aCML	A myelodysplastic/myeloproliferative disease characterized by the principal involvement of the neutrophil series with leukocytosis and multilineage dysplasia.  The neoplastic cells do not have a Philadelphia chromosome or the BCR/ABL fusion gene.  The prognosis is usually poor.  (WHO, 2001) -- 2003
C3520	Myeloid_Sarcoma	Acute_Myeloid_Leukemia_not_Otherwise_Categorized	Myeloid Sarcoma|Chloroma|Extramedullary Myeloid Tumor	A tumor mass composed of myeloblasts or immature myeloid cells.  It occurs in extramedullary sites or the bone.  (WHO, 2001) -- 2003
C3521	Placental_Polyp	Benign_Placental_Neoplasm|Polyp	Placental Polyp|Placenta Polyp|Polyp of Placenta|Polyp of the Placenta
C3522	Mammary_Duct_Ectasia	Non-Neoplastic_Breast_Disorder	Mammary Duct Ectasia|Comedomastitis|Ectasia of Mammary Duct|Ectasia of the Mammary Duct	Dilatation of the mammary duct without atypical cells.
C3523	Balanitis_Xerotica_Obliterans	Balanitis	Balanitis Xerotica Obliterans|Lichen Sclerosus of Penis|Lichen Sclerosus of the Penis|Penile Lichen Sclerosus
C3524	Malignant_Posterior_Tongue_Neoplasm	Malignant_Tongue_Neoplasm|Posterior_Tongue_Neoplasm	Malignant Posterior Tongue Neoplasm|Malignant Base of Tongue Neoplasm|Malignant Base of Tongue Tumor|Malignant Base of the Tongue Neoplasm|Malignant Base of the Tongue Tumor|Malignant Neoplasm of Base of Tongue|Malignant Neoplasm of Posterior Tongue|Malignant Neoplasm of the Base of the Tongue|Malignant Neoplasm of the Posterior Tongue|Malignant Posterior Tongue Tumor|Malignant Tumor of Base of Tongue|Malignant Tumor of Posterior Tongue|Malignant Tumor of the Base of the Tongue|Malignant Tumor of the Posterior Tongue
C3525	Malignant_Parotid_Gland_Neoplasm	Malignant_Major_Salivary_Gland_Neoplasm|Parotid_Gland_Neoplasm	Malignant Parotid Gland Neoplasm|Cancer of Parotid|Cancer of Parotid Gland|Cancer of the Parotid|Cancer of the Parotid Gland|Malignant Neoplasm of Parotid|Malignant Neoplasm of Parotid Gland|Malignant Neoplasm of the Parotid|Malignant Neoplasm of the Parotid Gland|Malignant Parotid Gland Tumor|Malignant Parotid Neoplasm|Malignant Parotid Tumor|Malignant Tumor of Parotid|Malignant Tumor of Parotid Gland|Malignant Tumor of the Parotid|Malignant Tumor of the Parotid Gland|Parotid Gland Cancer
C3526	Malignant_Submandibular_Gland_Neoplasm	Malignant_Major_Salivary_Gland_Neoplasm|Submandibular_Gland_Neoplasm	Malignant Submandibular Gland Neoplasm|Malignant Neoplasm of Submandibular Gland|Malignant Neoplasm of the Submandibular Gland|Malignant Submandibular Gland Tumor|Malignant Tumor of Submandibular Gland|Malignant Tumor of the Submandibular Gland
C3527	Malignant_Sublingual_Gland_Neoplasm	Malignant_Major_Salivary_Gland_Neoplasm|Sublingual_Gland_Neoplasm	Malignant Sublingual Gland Neoplasm|Malignant Neoplasm of Sublingual Gland|Malignant Neoplasm of the Sublingual Gland|Malignant Sublingual Gland Tumor|Malignant Tumor of Sublingual Gland|Malignant Tumor of the Sublingual Gland
C3528	Malignant_Hard_Palate_Neoplasm	Malignant_Oral_Cavity_Neoplasm|Malignant_Palate_Neoplasm	Malignant Hard Palate Neoplasm|Malignant Hard Palate Tumor|Malignant Neoplasm of Hard Palate|Malignant Neoplasm of the Hard Palate|Malignant Tumor of Hard Palate|Malignant Tumor of the Hard Palate
C3529	Malignant_Soft_Palate_Neoplasm	Malignant_Oropharyngeal_Neoplasm|Malignant_Palate_Neoplasm	Malignant Soft Palate Neoplasm|Malignant Neoplasm of Soft Palate|Malignant Neoplasm of the Soft Palate|Malignant Soft Palate Tumor|Malignant Tumor of Soft Palate|Malignant Tumor of the Soft Palate
C3530	Malignant_Palate_Neoplasm	Palate_Neoplasm	Malignant Palate Neoplasm|Cancer of Palate|Cancer of the Palate|Malignant Neoplasm of Palate|Malignant Neoplasm of the Palate|Malignant Palate Tumor|Malignant Tumor of Palate|Malignant Tumor of the Palate|Palate Cancer
C3531	Malignant_Pyriform_Fossa_Neoplasm	Malignant_Hypopharyngeal_Neoplasm|Pyriform_Fossa_Neoplasm	Malignant Pyriform Fossa Neoplasm|Malignant Neoplasm of Pyriform Fossa|Malignant Neoplasm of Pyriform Sinus|Malignant Neoplasm of the Pyriform Fossa|Malignant Neoplasm of the Pyriform Sinus|Malignant Pyriform Fossa Tumor|Malignant Pyriform Sinus Neoplasm|Malignant Pyriform Sinus Tumor|Malignant Tumor of Pyriform Fossa|Malignant Tumor of Pyriform Sinus|Malignant Tumor of the Pyriform Fossa|Malignant Tumor of the Pyriform Sinus
C3532	Malignant_Neoplasm_of_the_Thoracic_Esophagus	Malignant_Esophageal_Neoplasm_by_Anatomic_Region	Malignant Neoplasm of the Thoracic Esophagus|Malignant Neoplasm of Thoracic Esophagus	Clinical esophageal segment composed of smooth muscle.  It includes the middle third topographic segment, as well as parts of the upper and lower thirds.
C3533	Malignant_Neoplasm_of_the_Upper_Third_of_the_Esophagus	Malignant_Esophageal_Neoplasm_by_Topographic_Region	Malignant Neoplasm of the Upper Third of the Esophagus|Malignant Neoplasm of Proximal Third of Esophagus|Malignant Neoplasm of Upper Third of Esophagus|Malignant Neoplasm of the Proximal Third of the Esophagus|Malignant Tumor of Proximal Third of Esophagus|Malignant Tumor of Upper Third of Esophagus|Malignant Tumor of the Proximal Third of the Esophagus|Malignant Tumor of the Upper Third of the Esophagus
C3534	Malignant_Neoplasm_of_the_Middle_Third_of_the_Esophagus	Malignant_Esophageal_Neoplasm_by_Topographic_Region|Malignant_Neoplasm_of_the_Thoracic_Esophagus	Malignant Neoplasm of the Middle Third of the Esophagus|Malignant Middle Third of Esophagus Neoplasm|Malignant Middle Third of Esophagus Tumor|Malignant Middle Third of the Esophagus Neoplasm|Malignant Middle Third of the Esophagus Tumor|Malignant Neoplasm of Middle Third of Esophagus|Malignant Tumor of Middle Third of Esophagus|Malignant Tumor of the Middle Third of the Esophagus
C3535	Malignant_Neoplasm_of_the_Lower_Third_of_the_Esophagus	Malignant_Esophageal_Neoplasm_by_Topographic_Region	Malignant Neoplasm of the Lower Third of the Esophagus|Malignant Lower Third of Esophagus Neoplasm|Malignant Lower Third of Esophagus Tumor|Malignant Lower Third of the Esophagus Neoplasm|Malignant Lower Third of the Esophagus Tumor|Malignant Neoplasm of Distal Third of Esophagus|Malignant Neoplasm of Lower Third of Esophagus|Malignant Neoplasm of the Distal Third of the Esophagus|Malignant Tumor of Distal Third of Esophagus|Malignant Tumor of Lower Third of Esophagus|Malignant Tumor of the Distal Third of the Esophagus|Malignant Tumor of the Lower Third of the Esophagus
C3536	Malignant_Ampulla_of_Vater_Neoplasm	Ampulla_of_Vater_Neoplasm|Malignant_Gastrointestinal_Neoplasm	Malignant Ampulla of Vater Neoplasm|Malignant Ampulla of Vater Tumor|Malignant Neoplasm of Ampulla of Vater|Malignant Neoplasm of the Ampulla of Vater|Malignant Tumor of Ampulla of Vater|Malignant Tumor of the Ampulla of Vater	Malignant neoplasm originating in the ampulla of Vater.
C3537	Malignant_Retroperitoneal_Neoplasm	Retroperitoneal_Neoplasm	Malignant Retroperitoneal Neoplasm	A primary or metastatic malignant neoplasm involving the retroperitoneum.  The vast majority of cases are carcinomas, lymphomas, or sarcomas.--2004
C3538	Malignant_Peritoneal_Neoplasm	Peritoneal_Neoplasm	Malignant Peritoneal Neoplasm|Cancer of Peritoneum|Cancer of the Peritoneum|Peritoneal Cancer
C3539	Malignant_Splenic_Neoplasm	Splenic_Neoplasm	Malignant Splenic Neoplasm|Malignant Neoplasm of Spleen|Malignant Neoplasm of the Spleen|Malignant Splenic Tumor|Malignant Tumor of Spleen|Malignant Tumor of the Spleen
C3540	Malignant_Maxillary_Sinus_Neoplasm	Malignant_Paranasal_Sinus_Neoplasm|Maxillary_Sinus_Neoplasm	Malignant Maxillary Sinus Neoplasm|Malignant Maxillary Sinus Tumor|Malignant Neoplasm of Maxillary Sinus|Malignant Neoplasm of the Maxillary Sinus|Malignant Tumor of Maxillary Sinus|Malignant Tumor of the Maxillary Sinus
C3541	Malignant_Ethmoid_Sinus_Neoplasm	Ethmoid_Sinus_Neoplasm|Malignant_Paranasal_Sinus_Neoplasm	Malignant Ethmoid Sinus Neoplasm|Malignant Ethmoid Sinus Tumor|Malignant Ethmoidal Sinus Neoplasm|Malignant Ethmoidal Sinus Tumor|Malignant Neoplasm of Ethmoid Sinus|Malignant Neoplasm of Ethmoidal Sinus|Malignant Neoplasm of the Ethmoid Sinus|Malignant Neoplasm of the Ethmoidal Sinus|Malignant Tumor of Ethmoid Sinus|Malignant Tumor of Ethmoidal Sinus|Malignant Tumor of the Ethmoid Sinus|Malignant Tumor of the Ethmoidal Sinus
C3542	Malignant_Frontal_Sinus_Neoplasm	Frontal_Sinus_Neoplasm|Malignant_Paranasal_Sinus_Neoplasm	Malignant Frontal Sinus Neoplasm|Malignant Frontal Sinus Tumor|Malignant Neoplasm of Frontal Sinus|Malignant Neoplasm of the Frontal Sinus|Malignant Tumor of Frontal Sinus|Malignant Tumor of the Frontal Sinus
C3543	Malignant_Sphenoid_Sinus_Neoplasm	Malignant_Paranasal_Sinus_Neoplasm|Sphenoid_Sinus_Neoplasm	Malignant Sphenoid Sinus Neoplasm|Malignant Neoplasm of Sphenoid Sinus|Malignant Neoplasm of Sphenoidal Sinus|Malignant Neoplasm of the Sphenoid Sinus|Malignant Neoplasm of the Sphenoidal Sinus|Malignant Sphenoid Sinus Tumor|Malignant Sphenoidal Sinus Neoplasm|Malignant Sphenoidal Sinus Tumor|Malignant Tumor of Sphenoid Sinus|Malignant Tumor of Sphenoidal Sinus|Malignant Tumor of the Sphenoid Sinus|Malignant Tumor of the Sphenoidal Sinus
C3544	Malignant_Glottis_Neoplasm	Glottis_Neoplasm|Malignant_Laryngeal_Neoplasm	Malignant Glottis Neoplasm|Malignant Glottis Tumor|Malignant Neoplasm of Glottis|Malignant Neoplasm of the Glottis|Malignant Tumor of Glottis|Malignant Tumor of the Glottis	A malignant neoplasm arising in the glottic area of the larynx.  The vast majority of cases represent squamous cell carcinomas.--2004
C3545	Malignant_Supraglottis_Neoplasm	Malignant_Laryngeal_Neoplasm|Supraglottis_Neoplasm	Malignant Supraglottis Neoplasm|Malignant Neoplasm of Supraglottis|Malignant Neoplasm of the Supraglottis|Malignant Supraglottic Neoplasm|Malignant Supraglottic Tumor|Malignant Supraglottis Tumor|Malignant Tumor of Supraglottis|Malignant Tumor of the Supraglottis
C3546	Malignant_Subglottis_Neoplasm	Malignant_Laryngeal_Neoplasm|Subglottis_Neoplasm	Malignant Subglottis Neoplasm|Malignant Neoplasm of Subglottis|Malignant Neoplasm of the Subglottis|Malignant Subglottic Neoplasm|Malignant Subglottic Tumor|Malignant Subglottis Tumor|Malignant Tumor of Subglottis|Malignant Tumor of the Subglottis
C3547	Malignant_Pleural_Neoplasm	Malignant_Thoracic_Neoplasm|Pleural_Neoplasm	Malignant Pleural Neoplasm|Cancer of Pleura|Cancer of the Pleura|Malignant Neoplasm of Pleura|Malignant Neoplasm of the Pleura|Malignant Pleural Tumor|Malignant Tumor of Pleura|Malignant Tumor of the Pleura|Pleural Cancer	Malignant cancers originating in the pleura
C3548	Malignant_Cardiac_Neoplasm	Cardiac_Neoplasm|Malignant_Thoracic_Neoplasm	Malignant Cardiac Neoplasm|Cardiac Neoplasm Malignant NOS|Cardiac Neoplasms, Malignant|Malignant Cardiac Tumor|Malignant Heart Neoplasm|Malignant Heart Tumor|Malignant Neoplasm of Heart|Malignant Neoplasm of the Heart|Malignant Tumor of Heart|Malignant Tumor of the Heart	A primary or metastatic malignant neoplasm involving the heart
C3549	Malignant_Mediastinal_Neoplasm	Malignant_Thoracic_Neoplasm|Mediastinal_Neoplasm	Malignant Mediastinal Neoplasm|Cancer of Mediastinum|Cancer of the Mediastinum|Malignant Mediastinal Neoplasm NOS|Malignant Mediastinal Tumor|Malignant Neoplasm of Mediastinum|Malignant Neoplasm of the Mediastinum|Malignant Tumor of Mediastinum|Malignant Tumor of the Mediastinum|Mediastinal Cancer
C3550	Skin_Kaposi_s_Sarcoma	Kaposi_s_Sarcoma|Skin_Sarcoma	Skin Kaposi's Sarcoma|Cutaneous Kaposi's Sarcoma|Kaposi's Sarcoma of Skin|Kaposi's Sarcoma of the Skin
C3551	Lung_Kaposi_s_Sarcoma	Kaposi_s_Sarcoma|Lung_Sarcoma	Lung Kaposi's Sarcoma|Kaposi's Sarcoma of Lung|Kaposi's Sarcoma of the Lung|Pulmonary Kaposi's Sarcoma
C3552	Malignant_Uterine_Neoplasm	Malignant_Female_Reproductive_System_Neoplasm|Uterine_Neoplasm	Malignant Uterine Neoplasm|Cancer of Uterus|Cancer of the Uterus|Malignant Neoplasm of Uterus|Malignant Neoplasm of the Uterus|Malignant Tumor of Uterus|Malignant Tumor of the Uterus|Malignant Uterine Tumor|Uterine Cancer|Uterine Cancer NOS	Primary or metastatic malignant neoplasm involving the uterine corpus and/or the cervix. --2003
C3553	Malignant_Endocervical_Neoplasm	Malignant_Cervical_Neoplasm	Malignant Endocervical Neoplasm|Malignant Endocervical Tumor|Malignant Endocervix Neoplasm|Malignant Endocervix Tumor|Malignant Neoplasm of Endocervix|Malignant Neoplasm of Uterine Endocervix|Malignant Neoplasm of the Endocervix|Malignant Neoplasm of the Uterine Endocervix|Malignant Tumor of Endocervix|Malignant Tumor of Uterine Endocervix|Malignant Tumor of the Endocervix|Malignant Tumor of the Uterine Endocervix|Malignant Uterine Endocervix Neoplasm|Malignant Uterine Endocervix Tumor
C3554	Malignant_Exocervical_Neoplasm	Malignant_Cervical_Neoplasm	Malignant Exocervical Neoplasm|Malignant Exocervical Tumor|Malignant Exocervix Neoplasm|Malignant Exocervix Tumor|Malignant Neoplasm of Exocervix|Malignant Neoplasm of Uterine Exocervix|Malignant Neoplasm of the Exocervix|Malignant Neoplasm of the Uterine Exocervix|Malignant Tumor of Exocervix|Malignant Tumor of Uterine Exocervix|Malignant Tumor of the Exocervix|Malignant Tumor of the Uterine Exocervix|Malignant Uterine Exocervix Neoplasm|Malignant Uterine Exocervix Tumor
C3555	Malignant_Placental_Neoplasm	Placental_Neoplasm	Malignant Placental Neoplasm|Malignant Neoplasm of Placenta|Malignant Neoplasm of the Placenta|Malignant Placenta Neoplasm|Malignant Placenta Tumor|Malignant Placental Tumor|Malignant Tumor of Placenta|Malignant Tumor of the Placenta	Malignant neoplasm originating in the placenta
C3556	Malignant_Uterine_Corpus_Neoplasm	Malignant_Uterine_Neoplasm|Uterine_Corpus_Neoplasm	Malignant Uterine Corpus Neoplasm|Malignant Corpus Uteri Neoplasm|Malignant Corpus Uteri Tumor|Malignant Neoplasm of Uterine Body|Malignant Neoplasm of the Uterine Body|Malignant Tumor of Uterine Body|Malignant Tumor of the Uterine Body|Malignant Uterine Body Neoplasm|Malignant Uterine Body Tumor|Malignant Uterine Corpus Tumor
C3557	Malignant_Clitoral_Neoplasm	Malignant_Vulvar_Neoplasm	Malignant Clitoral Neoplasm|Malignant Clitoral Tumor|Malignant Clitoris Neoplasm|Malignant Clitoris Tumor|Malignant Neoplasm of Clitoris|Malignant Neoplasm of the Clitoris|Malignant Tumor of Clitoris|Malignant Tumor of the Clitoris
C3558	Malignant_Epididymal_Neoplasm	Epididymal_Neoplasm|Malignant_Male_Reproductive_System_Neoplasm	Malignant Epididymal Neoplasm|Malignant Epididymal Tumor|Malignant Neoplasm of Epididymis|Malignant Neoplasm of the Epididymis|Malignant Tumor of Epididymis|Malignant Tumor of the Epididymis	Malignant neoplasm of the epididymis
C3559	Malignant_Spermatic_Cord_Neoplasm	Malignant_Male_Reproductive_System_Neoplasm	Malignant Spermatic Cord Neoplasm|Malignant Neoplasm of Spermatic Cord|Malignant Neoplasm of the Spermatic Cord|Malignant Spermatic Cord Tumor|Malignant Tumor of Spermatic Cord|Malignant Tumor of the Spermatic Cord	Malignant neoplasm involving the spermatic cord.
C3560	Malignant_Scrotal_Neoplasm	Malignant_Skin_Neoplasm|Scrotal_Neoplasm	Malignant Scrotal Neoplasm|Malignant Neoplasm of Scrotum|Malignant Neoplasm of the Scrotum|Malignant Scrotal Tumor|Malignant Tumor of Scrotum|Malignant Tumor of the Scrotum	A primary or metastatic malignant tumor affecting the scrotum. -- 2003
C3561	Malignant_Paraurethral_Gland_Neoplasm	Malignant_Urethral_Neoplasm|Paraurethral_Gland_Neoplasm	Malignant Paraurethral Gland Neoplasm|Malignant Neoplasm of Paraurethral Gland|Malignant Neoplasm of Paraurethral Glands|Malignant Neoplasm of the Paraurethral Gland|Malignant Paraurethral Gland Tumor|Malignant Tumor of Paraurethral Gland|Malignant Tumor of the Paraurethral Gland	Malignant neoplasm involving the paraurethral glands
C3562	Malignant_Orbit_Neoplasm	Orbit_Neoplasm	Malignant Orbit Neoplasm|Malignant Neoplasm of Orbit|Malignant Neoplasm of the Orbit|Malignant Orbit Tumor|Malignant Orbital Neoplasm|Malignant Orbital Tumor|Malignant Tumor of Orbit|Malignant Tumor of the Orbit	A primary or metastatic malignant neoplasm involving the orbit.
C3563	Malignant_Lacrimal_Gland_Neoplasm	Lacrimal_Gland_Neoplasm|Malignant_Eye_Neoplasm	Malignant Lacrimal Gland Neoplasm|Malignant Lacrimal Gland Tumor|Malignant Neoplasm of Lacrimal Gland|Malignant Neoplasm of the Lacrimal Gland|Malignant Tumor of Lacrimal Gland|Malignant Tumor of the Lacrimal Gland	Abnormal growth of cells comprising the lacrimal gland with malignant characteristics.
C3564	Malignant_Conjunctival_Neoplasm	Conjunctival_Neoplasm|Malignant_Eye_Neoplasm	Malignant Conjunctival Neoplasm|Malignant Conjunctiva Neoplasm|Malignant Conjunctiva Tumor|Malignant Conjunctival Tumor|Malignant Neoplasm of Conjunctiva|Malignant Neoplasm of the Conjunctiva|Malignant Tumor of Conjunctiva|Malignant Tumor of the Conjunctiva	A malignant growth of cells within the conjunctiva of the eye.
C3565	Malignant_Corneal_Neoplasm	Corneal_Neoplasm|Malignant_Eye_Neoplasm	Malignant Corneal Neoplasm|Malignant Cornea Neoplasm|Malignant Cornea Tumor|Malignant Corneal Tumor|Malignant Neoplasm of Cornea|Malignant Neoplasm of the Cornea|Malignant Tumor of Cornea|Malignant Tumor of the Cornea	A malignant growth of cells within the cornea of the eye.
C3566	Malignant_Choroid_Neoplasm	Choroid_Neoplasm|Malignant_Uveal_Neoplasm	Malignant Choroid Neoplasm|Malignant Choroid Tumor|Malignant Neoplasm of Choroid|Malignant Neoplasm of the Choroid|Malignant Tumor of Choroid|Malignant Tumor of the Choroid	Malignant growth of tissues that comprise the choroid body.
C3567	Malignant_Lacrimal_Duct_Neoplasm	Lacrimal_System_Neoplasm|Malignant_Eye_Neoplasm	Malignant Lacrimal Duct Neoplasm|Malignant Lacrimal Duct Tumor|Malignant Neoplasm of Lacrimal Duct|Malignant Neoplasm of the Lacrimal Duct|Malignant Tumor of Lacrimal Duct|Malignant Tumor of the Lacrimal Duct	Malignant growth of tissues that comprise the lacrimal duct.
C3568	Malignant_Brain_Neoplasm	Brain_Neoplasm|Malignant_Central_Nervous_System_Neoplasm|Malignant_Intracranial_Neoplasm	Malignant Brain Neoplasm|Brain Cancer|Brain Neoplasms, Malignant|Cancer of Brain|Cancer of the Brain|Malignant Brain Tumor|Malignant Neoplasm of Brain|Malignant Neoplasm of the Brain|Malignant Tumor of Brain|Malignant Tumor of the Brain
C3569	Malignant_Cerebellar_Neoplasm	Cerebellar_Neoplasm|Malignant_Infratentorial_Neoplasm	Malignant Cerebellar Neoplasm|Cancer of Cerebellum|Cancer of the Cerebellum|Cerebellar Cancer|Cerebellar Neoplasm, Malignant|Cerebellar Tumor, Malignant|Malignant Cerebellar Neoplasms|Malignant Cerebellar Tumor|Malignant Neoplasm of Cerebellum|Malignant Neoplasm of the Cerebellum|Malignant Tumor of Cerebellum|Malignant Tumor of the Cerebellum	Primary and secondary (metastatic) malignant tumors that occur in the cerebellum.  Histologic types include medulloblastomas, high grade (WHO Stage III or IV) cerebellar astrocytomas, lymphomas, gangliogliomas, gliosarcomas, and several other subtypes.  The most frequent malignant cerebellar neoplasm of childhood is medulloblastoma. In adults, metastases from other sites are relatively common. Clinical features include ataxia, headache, nausea, dizzyness, nystagmus, diplopia, papilledema, etc. (KEV 8-7-99)
C3570	Malignant_Brain_Stem_Neoplasm	Brain_Stem_Neoplasm|Malignant_Infratentorial_Neoplasm	Malignant Brain Stem Neoplasm|Malignant Brain Stem Tumor|Malignant Brainstem Neoplasm|Malignant Brainstem Tumor|Malignant Neoplasm of Brain Stem|Malignant Neoplasm of Brainstem|Malignant Neoplasm of the Brain Stem|Malignant Neoplasm of the Brainstem|Malignant Tumor of Brain Stem|Malignant Tumor of Brainstem|Malignant Tumor of the Brain Stem|Malignant Tumor of the Brainstem
C3571	Malignant_Cranial_Nerve_Neoplasm	Cranial_Nerve_Neoplasm|Malignant_Nervous_System_Neoplasm	Malignant Cranial Nerve Neoplasm|Cranial Nerve Neoplasm, Malignant|Malignant Cranial Nerve Tumor|Malignant Neoplasm of Cranial Nerve|Malignant Neoplasm of the Cranial Nerve|Malignant Tumor of Cranial Nerve|Malignant Tumor of the Cranial Nerve	Abnormal malignant growth of the cells that comprise the cranial nerve.
C3572	Malignant_Spinal_Cord_Neoplasm	Spinal_Cord_Neoplasm	Malignant Spinal Cord Neoplasm|Malignant Neoplasm of Spinal Cord|Malignant Neoplasm of the Spinal Cord|Malignant Spinal Cord Tumor|Malignant Tumor of Spinal Cord|Malignant Tumor of the Spinal Cord
C3573	Malignant_Pineal_Region_Neoplasm	Malignant_Supratentorial_Neoplasm|Pineal_Region_Neoplasm	Malignant Pineal Region Neoplasm|Malignant Neoplasm of Pineal Gland|Malignant Neoplasm of the Pineal Gland|Malignant Pineal Area Neoplasm|Malignant Pineal Area Tumor|Malignant Pineal Gland Neoplasm|Malignant Pineal Gland Tumor|Malignant Pineal Region Tumor|Malignant Tumor of Pineal Gland|Malignant Tumor of the Pineal Gland	Abnormal malignant growth of the cells that comprise the pineal parenchyma.
C3574	Malignant_Carotid_Body_Paraganglioma	Carotid_Body_Paraganglioma|Malignant_Extra-Adrenal_Paraganglioma	Malignant Carotid Body Paraganglioma|Malignant Carotid Body Neoplasm|Malignant Carotid Body Tumor|Malignant Neoplasm of Carotid Body|Malignant Neoplasm of the Carotid Body|Malignant Tumor of Carotid Body|Malignant Tumor of the Carotid Body	A carotid body paraganglioma that metastasizes to other anatomic sites.
C3575	Malignant_Endocrine_Neoplasm	Endocrine_Neoplasm	Malignant Endocrine Neoplasm|Endocrine Neoplasms Malignant|Malignant Endocrine Gland Neoplasm|Malignant Endocrine Gland Tumor|Malignant Endocrine Tumor|Malignant Neoplasm of Endocrine Gland|Malignant Neoplasm of the Endocrine Gland|Malignant Tumor of Endocrine Gland|Malignant Tumor of the Endocrine Gland|endocrine cancer	Cancer that occurs in endocrine tissue, the tissue in the body that secretes hormones.
C3576	Malignant_Thoracic_Neoplasm	Thoracic_Neoplasm	Malignant Thoracic Neoplasm|Malignant Neoplasm of Thorax|Malignant Neoplasm of the Thorax|Malignant Thoracic Tumor|Malignant Tumor of Thorax|Malignant Tumor of the Thorax	Malignant growth of cells comprising the tissues of the thorax
C3577	Metastatic_Neoplasm_to_the_Lung	Malignant_Lung_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Lung|Lung Metastases|Metastases to Lung|Metastasis to Lung|Metastasis to the Lung|Metastatic Neoplasm to the Lung|Metastatic Tumor to the Lung|lung metastases	Cancer that has spread from the original (primary) tumor to the lung.
C3578	Metastatic_Neoplasm_to_the_Mediastinum	Malignant_Mediastinal_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Mediastinum|Metastases to Mediastinum|Metastases to the Mediastinum|Metastasis to the Mediastinum|Metastatic Neoplasm to the Mediastinum|Metastatic Tumor to the Mediastinum	The spread of cancer to the mediastinum from an adjacent or distant anatomic site.
C3579	Metastatic_Neoplasm_to_the_Pleura	Malignant_Pleural_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Pleura|Metastases to Pleura|Metastasis to the Pleura|Metastatic Neoplasm to the Pleura|Metastatic Tumor to the Pleura	The spread of cancer to the pleura from an adjacent or distant anatomic site.
C3580	Metastatic_Neoplasm_to_the_Bone	Malignant_Bone_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Bone|Bone Metastases|Bone Metastasis|Metastatic Cancer to the Bone|Metastatic Neoplasm to the Bone|Metastatic Tumor to the Bone|bone metastases	Cancer that has spread from the original (primary) tumor to the bone.
C3581	Stage_III_Nodular_Sclerosis_Hodgkin_s_Lymphoma	Nodular_Sclerosis_Hodgkin_s_Lymphoma|Stage_III_Hodgkin_s_Lymphoma	Stage III Nodular Sclerosis Hodgkin's Lymphoma|Nodular Sclerosis Hodgkin's Disease Stage III|Nodular Sclerosis Hodgkin's Lymphoma Stage III|Stage III Nodular Sclerosis Hodgkin Lymphoma|Stage III Nodular Sclerosis Hodgkin's Disease	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C3582	Stage_III_Mixed_Cellularity_Hodgkin_s_Lymphoma	Mixed_Cellularity_Hodgkin_s_Lymphoma|Stage_III_Hodgkin_s_Lymphoma	Stage III Mixed Cellularity Hodgkin's Lymphoma|Mixed Cellularity Hodgkin's Disease Stage III|Mixed Cellularity Hodgkin's Lymphoma Stage III|Stage III Mixed Cellularity Hodgkin Lymphoma|Stage III Mixed Cellularity Hodgkin's Disease	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C3583	Stage_III_Lymphocyte_Depleted_Hodgkin_s_Lymphoma	Lymphocyte_Depleted_Hodgkin_s_Lymphoma|Stage_III_Hodgkin_s_Lymphoma	Stage III Lymphocyte Depleted Hodgkin's Lymphoma|Stage III Hodgkin's Disease Lymphocyte Depletion Type|Stage III Hodgkin's Lymphoma Lymphocyte Depleted|Stage III Hodgkin's Lymphoma Lymphocyte Depletion Type	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C3584	Stage_III_Hodgkin_s_Lymphoma	Hodgkin_s_Lymphoma|Stage_III_Lymphoma	Stage III Hodgkin's Lymphoma|Hodgkin's Disease Stage III|Hodgkin's Lymphoma Stage III|Stage III Hodgkin Lymphoma|Stage III Hodgkin's Disease|Stage III Hodgkins Disease|Stage III Hodgkins Lymphoma|stage III Hodgkin's disease	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C3585	Plasma_Cell_Leukemia_in_Remission	Lymphoid_Leukemia_in_Remission	Plasma Cell Leukemia in Remission|Leukemia Plasmacytic (in Remission)|Plasmacytic Leukemia (in Remission)|Plasmacytic Leukemia in Remission	History of plasmacytic leukemia after therapy with no evidence on the peripheral blood or bone marrow of leukemia (normalization of all hematologic parameters).
C3586	Acute_Lymphoblastic_Leukemia_in_Remission	Acute_Leukemia_in_Remission|Lymphoid_Leukemia_in_Remission	Acute Lymphoblastic Leukemia in Remission|ALL in Remission|Acute Lymphocytic Leukemia (in Remission)|Acute Lymphocytic Leukemia in Remission|Acute Lymphogenous Leukemia in Remission|Acute Lymphoid Leukemia in Remission	Acute lymphocytic leukemia not growing; responding to treatment.
C3587	Chronic_Lymphocytic_Leukemia_in_Remission	Chronic_Leukemia_in_Remission|Lymphoid_Leukemia_in_Remission	Chronic Lymphocytic Leukemia in Remission|CLL in Remission|Chronic Lymphocytic Leukemia (in Remission)|Chronic Lymphogenous Leukemia in Remission|Chronic Lymphoid Leukemia in Remission	Chronic lymphocytic leukemia not growing, responding to treatment.
C3588	Acute_Myeloid_Leukemia_in_Remission	Acute_Leukemia_in_Remission|Myeloid_Leukemia_in_Remission	Acute Myeloid Leukemia in Remission|AML in Remission|ANLL in Remission|Acute Granulocytic Leukemia in Remission|Acute Myeloblastic Leukemia in Remission|Acute Myelocytic Leukemia in Remission|Acute Myelogenous Leukemia in Remission|Acute Myeloid Leukemia (in Remission)|Acute Non-Lymphoblastic Leukemia in Remission|Acute Non-Lymphocytic Leukemia in Remission|Acute Nonlymphoblastic Leukemia in Remission|Acute Nonlymphocytic Leukemia in Remission	Acute myeloid leukemia not growing, responding to treatment
C3589	Chronic_Myelogenous_Leukemia_in_Remission	Chronic_Leukemia_in_Remission|Myeloid_Leukemia_in_Remission	Chronic Myelogenous Leukemia in Remission|CML in Remission|Chronic Granulocytic Leukemia in Remission|Chronic Myelocytic Leukemia in Remission|Chronic Myeloid Leukemia (in Remission)|Chronic Myeloid Leukemia in Remission	Chronic myeloid leukemia not growing; responding to treatment
C3590	Acute_Monocytic_Leukemia_in_Remission	Acute_Myeloid_Leukemia_in_Remission	Acute Monocytic Leukemia in Remission|Acute Monocytic Leukemia (in Remission)|Monocytic Leukemia (in Remission)|Monocytic Leukemia in Remission	An acute monocytic leukemia responding to treatment and not proliferating
C3591	Benign_Lip_Neoplasm	Benign_Oral_Neoplasm|Lip_Neoplasm	Benign Lip Neoplasm|Benign Lip Tumor|Benign Neoplasm of Lip|Benign Neoplasm of the Lip|Benign Tumor of Lip|Benign Tumor of the Lip|Lip Neoplasm, Benign	Abnormal growth, without malignant characteristics, of the cells that comprise the lips of the mouth.
C3592	Benign_Tongue_Neoplasm	Tongue_Neoplasm	Benign Tongue Neoplasm|Benign Neoplasm of Tongue|Benign Neoplasm of the Tongue|Benign Tongue Tumor|Benign Tumor of Tongue|Benign Tumor of the Tongue|Tongue Neoplasm, Benign	Abnormal growth, without malignant characteristics, of the cells that comprise the tongue.
C3593	Benign_Floor_of_the_Mouth_Neoplasm	Benign_Oral_Cavity_Neoplasm|Floor_of_the_Mouth_Neoplasm	Benign Floor of the Mouth Neoplasm|Benign Floor of Mouth Neoplasm|Benign Floor of Mouth Tumor|Benign Floor of the Mouth Tumor|Benign Neoplasm of Floor of Mouth|Benign Neoplasm of the Floor of the Mouth|Benign Tumor of Floor of Mouth|Benign Tumor of the Floor of the Mouth
C3594	Benign_Tonsillar_Neoplasm	Benign_Oropharyngeal_Neoplasm|Tonsillar_Neoplasm	Benign Tonsillar Neoplasm|Benign Neoplasm of Tonsil|Benign Neoplasm of the Tonsil|Benign Tonsil Neoplasm|Benign Tonsil Tumor|Benign Tonsillar Tumor|Benign Tumor of Tonsil|Benign Tumor of the Tonsil|Tonsillar Neoplasm, Benign
C3595	Benign_Nasopharyngeal_Neoplasm	Benign_Pharyngeal_Neoplasm|Nasopharyngeal_Neoplasm	Benign Nasopharyngeal Neoplasm|Benign Nasopharyngeal Tumor|Benign Neoplasm of Nasopharynx|Benign Neoplasm of the Nasopharynx|Benign Tumor of Nasopharynx|Benign Tumor of the Nasopharynx|Nasopharyngeal Neoplasm, Benign
C3596	Benign_Hypopharyngeal_Neoplasm	Benign_Pharyngeal_Neoplasm|Hypopharyngeal_Neoplasm	Benign Hypopharyngeal Neoplasm|Benign Hypopharyngeal Tumor|Benign Neoplasm of Hypopharynx|Benign Neoplasm of the Hypopharynx|Benign Tumor of Hypopharynx|Benign Tumor of the Hypopharynx|Hypopharyngeal Neoplasm, Benign
C3597	Benign_Pharyngeal_Neoplasm	Benign_Neck_Neoplasm|Pharyngeal_Neoplasm	Benign Pharyngeal Neoplasm|Benign Neoplasm of Pharynx|Benign Neoplasm of the Pharynx|Benign Pharyngeal Tumor|Benign Pharynx Neoplasm|Benign Pharynx Tumor|Benign Tumor of Pharynx|Benign Tumor of the Pharynx|Pharyngeal Neoplasm Benign
C3598	Benign_Esophageal_Neoplasm	Benign_Gastrointestinal_Neoplasm|Esophageal_Neoplasm	Benign Esophageal Neoplasm|Benign Esophageal Tumor|Benign Esophagus Neoplasm|Benign Esophagus Tumor|Benign Neoplasm of Esophagus|Benign Neoplasm of the Esophagus|Benign Tumor of Esophagus|Benign Tumor of the Esophagus	A tumor in the esophageal lumen which does not invade the esophageal wall and does not metastasize.  (WHO, 2000) -- 2003
C3599	Benign_Gastric_Neoplasm	Benign_Gastrointestinal_Neoplasm|Gastric_Neoplasm	Benign Gastric Neoplasm|Benign Gastric Tumor|Benign Gastric Tumors|Benign Neoplasm of Stomach|Benign Neoplasm of the Stomach|Benign Stomach Neoplasms|Benign Stomach Tumors|Benign Tumor of Stomach|Benign Tumor of the Stomach|Benign Tumors of Stomach|Benign Tumors of the Stomach|Gastric Neoplasms, Benign|Gastric Tumors, Benign|Stomach Neoplasms, Benign|Stomach Tumors, Benign	Abnormal growth of the cells that comprise the stomach without evidence of malignancy.
C3600	Benign_Small_Intestinal_Neoplasm	Benign_Intestinal_Neoplasm|Small_Intestinal_Neoplasm	Benign Small Intestinal Neoplasm|Benign Neoplasm of Small Intestine|Benign Neoplasm of the Small Intestine|Benign Small Intestinal Neoplasm NOS|Benign Small Intestinal Tumor|Benign Small Intestine Neoplasm|Benign Small Intestine Tumor|Benign Tumor of Small Intestine|Benign Tumor of the Small Intestine
C3601	Benign_Laryngeal_Neoplasm	Benign_Neck_Neoplasm|Laryngeal_Neoplasm	Benign Laryngeal Neoplasm|Benign Laryngeal Tumor|Benign Larynx Neoplasm|Benign Larynx Tumor|Benign Neoplasm of Larynx|Benign Neoplasm of the Larynx|Benign Tumor of Larynx|Benign Tumor of the Larynx|Laryngeal Neoplasm, Benign
C3602	Benign_Tracheal_Neoplasm	Benign_Respiratory_Tract_Neoplasm|Tracheal_Neoplasm	Benign Tracheal Neoplasm|Benign Neoplasm of Trachea|Benign Neoplasm of the Trachea|Benign Trachea Neoplasm|Benign Trachea Tumor|Benign Tracheal Tumor|Benign Tumor of Trachea|Benign Tumor of the Trachea
C3603	Benign_Pleural_Neoplasm	Benign_Thoracic_Neoplasm|Pleural_Neoplasm	Benign Pleural Neoplasm|Benign Neoplasm of Pleura|Benign Neoplasm of the Pleura|Benign Pleural Tumor|Benign Tumor of Pleura|Benign Tumor of the Pleura
C3604	Benign_Mediastinal_Neoplasm	Benign_Thoracic_Neoplasm|Mediastinal_Neoplasm	Benign Mediastinal Neoplasm|Benign Mediastinal Neoplasms NOS|Benign Mediastinal Tumor|Benign Neoplasm of Mediastinum|Benign Neoplasm of the Mediastinum|Benign Tumor of Mediastinum|Benign Tumor of the Mediastinum	Abnormal growth of the cells of the tissues contained within the mediastinum (e.g., thymus) without evidence of malignancy.
C3605	Benign_Cardiac_Neoplasm	Benign_Thoracic_Neoplasm|Cardiac_Neoplasm	Benign Cardiac Neoplasm|Benign Cardiac Neoplasms|Benign Cardiac Tumor|Benign Cardiac Tumors|Benign Heart Neoplasm|Benign Heart Tumor|Benign Neoplasm of Heart|Benign Neoplasm of the Heart|Benign Tumor of Heart|Benign Tumor of the Heart|Cardiac Neoplasms, Benign|Cardiac Tumors, Benign	Abnormal growth of the cells comprising the cardiac muscle, valves, and/or vessels without any malignant characteristics
C3606	Spermatic_Cord_Lipoma	Paratesticular_Lipoma	Spermatic Cord Lipoma|Lipoma of Spermatic Cord|Lipoma of the Spermatic Cord
C3607	Benign_Cervical_Neoplasm	Benign_Uterine_Neoplasm|Cervical_Neoplasm	Benign Cervical Neoplasm|Benign Cervix Uteri Neoplasm|Benign Cervix Uteri Neoplasm NOS|Benign Cervix Uteri Tumor|Benign Neoplasm of Cervix Uteri|Benign Neoplasm of Uterine Cervix|Benign Neoplasm of the Cervix Uteri|Benign Neoplasm of the Uterine Cervix|Benign Tumor of Cervix Uteri|Benign Tumor of Uterine Cervix|Benign Tumor of the Cervix Uteri|Benign Tumor of the Uterine Cervix|Benign Uterine Cervix Neoplasm|Benign Uterine Cervix Tumor
C3608	Benign_Uterine_Corpus_Neoplasm	Benign_Uterine_Neoplasm|Uterine_Corpus_Neoplasm	Benign Uterine Corpus Neoplasm|Benign Corpus Uteri Neoplasm|Benign Corpus Uteri Tumor|Benign Neoplasm of Body of Uterus|Benign Neoplasm of Corpus Uteri|Benign Neoplasm of Uterine Body|Benign Neoplasm of Uterine Corpus|Benign Neoplasm of the Body of Uterus|Benign Neoplasm of the Corpus Uteri|Benign Neoplasm of the Uterine Body|Benign Neoplasm of the Uterine Corpus|Benign Tumor of Body of Uterus|Benign Tumor of Corpus Uteri|Benign Tumor of Uterine Body|Benign Tumor of Uterine Corpus|Benign Tumor of the Body of Uterus|Benign Tumor of the Corpus Uteri|Benign Tumor of the Uterine Body|Benign Tumor of the Uterine Corpus|Benign Uterine Body Neoplasm|Benign Uterine Body Tumor|Benign Uterine Corpus Tumor
C3609	Benign_Uterine_Neoplasm	Benign_Female_Reproductive_System_Neoplasm|Uterine_Neoplasm	Benign Uterine Neoplasm|Benign Neoplasm of Uterus|Benign Neoplasm of the Uterus|Benign Tumor of Uterus|Benign Tumor of the Uterus|Benign Uterine Neoplasm NOS|Benign Uterine Neoplasms|Benign Uterine Tumor|Benign Uterine Tumors|Benign Uterus Neoplasm|Benign Uterus Neoplasms|Benign Uterus Tumor|Benign Uterus Tumors|Uterine Neoplasms, Benign|Uterine Tumors, Benign|Uterous Neoplasms, Benign|Uterous Tumors, Benign	Abnormal growth of the cells of the uterus without malignant characteristics noted clinically or histologically.
C3610	Benign_Vaginal_Neoplasm	Benign_Female_Reproductive_System_Neoplasm|Vaginal_Neoplasm	Benign Vaginal Neoplasm|Benign Neoplasm of Vagina|Benign Neoplasm of the Vagina|Benign Tumor of Vagina|Benign Tumor of the Vagina|Benign Vaginal Neoplasms|Benign Vaginal Tumor
C3611	Benign_Vulvar_Neoplasm	Benign_Female_Reproductive_System_Neoplasm|Vulvar_Neoplasm	Benign Vulvar Neoplasm|Benign Neoplasm of Vulva|Benign Neoplasm of the Vulva|Benign Tumor of Vulva|Benign Tumor of the Vulva|Benign Vulva Neoplasm|Benign Vulva Tumor|Benign Vulval Neoplasm|Benign Vulvar Tumor
C3612	Benign_Testicular_Neoplasm	Benign_Male_Reproductive_System_Neoplasm|Testicular_Neoplasm	Benign Testicular Neoplasm|Benign Neoplasm of Testis|Benign Neoplasm of the Testis|Benign Testicular Tumor|Benign Tumor of Testis|Benign Tumor of the Testis	Abnormal growth of the tissues of the testes without evidence of malignancy
C3613	Benign_Prostate_Neoplasm	Benign_Male_Reproductive_System_Neoplasm|Prostate_Neoplasm	Benign Prostate Neoplasm|Benign Neoplasm of Prostate|Benign Neoplasm of the Prostate|Benign Prostate Tumor|Benign Prostatic Neoplasm|Benign Tumor of Prostate|Benign Tumor of the Prostate
C3614	Benign_Epididymal_Neoplasm	Benign_Male_Reproductive_System_Neoplasm|Epididymal_Neoplasm	Benign Epididymal Neoplasm|Benign Epididymal Tumor|Benign Neoplasm of Epididymis|Benign Neoplasm of the Epididymis|Benign Tumor of Epididymis|Benign Tumor of the Epididymis
C3615	Benign_Scrotal_Neoplasm	Benign_Skin_Neoplasm|Scrotal_Neoplasm	Benign Scrotal Neoplasm|Benign Neoplasm of Scrotum|Benign Neoplasm of the Scrotum|Benign Scrotal Tumor|Benign Tumor of Scrotum|Benign Tumor of the Scrotum
C3616	Benign_Renal_Pelvis_Neoplasm	Benign_Renal_Neoplasm|Renal_Pelvis_Neoplasm	Benign Renal Pelvis Neoplasm|Benign Kidney Pelvis Neoplasm|Benign Neoplasm of Renal Pelvis|Benign Neoplasm of the Renal Pelvis|Benign Renal Pelvis Tumor|Benign Tumor of Renal Pelvis|Benign Tumor of the Renal Pelvis
C3617	Benign_Ureter_Neoplasm	Benign_Urinary_Tract_Neoplasm|Ureter_Neoplasm	Benign Ureter Neoplasm|Benign Neoplasm of Ureter|Benign Neoplasm of the Ureter|Benign Tumor of Ureter|Benign Tumor of the Ureter|Benign Ureter Tumor|Benign Ureteral Neoplasm|Benign Ureteral Tumor|Benign Ureteric Neoplasm|Benign Ureteric Neoplasm NOS	Abnormal growth of the cells of the ureter (upper urinary tract) without malignant characteristics.
C3618	Benign_Bladder_Neoplasm	Benign_Urinary_Tract_Neoplasm|Bladder_Neoplasm	Benign Bladder Neoplasm|Benign Bladder Tumor|Benign Neoplasm of Bladder|Benign Neoplasm of Urinary Bladder|Benign Neoplasm of the Bladder|Benign Neoplasm of the Urinary Bladder|Benign Tumor of Bladder|Benign Tumor of Urinary Bladder|Benign Tumor of the Bladder|Benign Tumor of the Urinary Bladder|Benign Urinary Bladder Neoplasm|Benign Urinary Bladder Tumor	A benign abnormal growth of the cells that comprise the bladder.
C3619	Benign_Urethral_Neoplasm	Benign_Urinary_Tract_Neoplasm|Urethra_Neoplasm	Benign Urethral Neoplasm|Benign Neoplasm of Urethra|Benign Neoplasm of the Urethra|Benign Tumor of Urethra|Benign Tumor of the Urethra|Benign Urethra Neoplasm|Benign Urethra Tumor|Benign Urethral Neoplasm NOS|Benign Urethral Tumor	Abnormal growth of the cells of the urethra (lower urinary tract) without malignant characteristics.
C3620	Benign_Orbit_Neoplasm	Orbit_Neoplasm	Benign Orbit Neoplasm|Benign Neoplasm of Orbit|Benign Neoplasm of the Orbit|Benign Orbit Tumor|Benign Orbital Neoplasm|Benign Orbital Tumor|Benign Tumor of Orbit|Benign Tumor of the Orbit	Abnormal growth of the cells of the orbit that has no evidence of malignant characteristics.
C3621	Benign_Lacrimal_Gland_Neoplasm	Benign_Eye_Neoplasm|Lacrimal_Gland_Neoplasm	Benign Lacrimal Gland Neoplasm|Benign Lacrimal Gland Tumor|Benign Neoplasm of Lacrimal Gland|Benign Neoplasm of the Lacrimal Gland|Benign Tumor of Lacrimal Gland|Benign Tumor of the Lacrimal Gland	Abnormal growth of the cells of the lacrimal gland without malignant characteristics.
C3622	Benign_Conjunctival_Neoplasm	Benign_Eye_Neoplasm|Conjunctival_Neoplasm	Benign Conjunctival Neoplasm|Benign Conjunctiva Neoplasm|Benign Conjunctiva Tumor|Benign Conjunctival Tumor|Benign Neoplasm of Conjunctiva|Benign Neoplasm of the Conjunctiva|Benign Tumor of Conjunctiva|Benign Tumor of the Conjunctiva	Abnormal growth of the cells of the conjunctiva without malignant characteristics.
C3623	Benign_Corneal_Neoplasm	Benign_Eye_Neoplasm|Corneal_Neoplasm	Benign Corneal Neoplasm|Benign Cornea Neoplasm|Benign Cornea Tumor|Benign Corneal Tumor|Benign Neoplasm of Cornea|Benign Neoplasm of the Cornea|Benign Tumor of Cornea|Benign Tumor of the Cornea	Abnormal growth of the cells of the cornea without malignant characteristics.
C3624	Benign_Retinal_Neoplasm	Benign_Eye_Neoplasm|Retinal_Neoplasm	Benign Retinal Neoplasm|Benign Neoplasm of Retina|Benign Neoplasm of the Retina|Benign Retina Neoplasm|Benign Retina Tumor|Benign Retinal Tumor|Benign Tumor of Retina|Benign Tumor of the Retina	Abnormal growth of the cells of the retina without malignant characteristics.
C3625	Benign_Choroid_Neoplasm	Benign_Uveal_Neoplasm|Choroid_Neoplasm	Benign Choroid Neoplasm|Benign Choroid Tumor|Benign Neoplasm of Choroid|Benign Neoplasm of the Choroid|Benign Tumor of Choroid|Benign Tumor of the Choroid	Abnormal growth of the cells of the choroid without malignant characteristics.
C3626	Benign_Lacrimal_Duct_Neoplasm	Benign_Eye_Neoplasm|Lacrimal_System_Neoplasm	Benign Lacrimal Duct Neoplasm|Benign Lacrimal Duct Tumor|Benign Neoplasm of Lacrimal Duct|Benign Neoplasm of the Lacrimal Duct|Benign Tumor of Lacrimal Duct|Benign Tumor of the Lacrimal Duct	Abnormal growth of the cells of the lacrimal duct without malignant characteristics.
C3627	Benign_Spinal_Cord_Neoplasm	Spinal_Cord_Neoplasm	Benign Spinal Cord Neoplasm|Benign Neoplasm of Spinal Cord|Benign Neoplasm of the Spinal Cord|Benign Spinal Cord Tumor|Benign Tumor of Spinal Cord|Benign Tumor of the Spinal Cord|Spinal Cord Neoplasm, Benign	A benign growth of the cells that comprise the spinal cord.
C3628	Benign_Thyroid_Neoplasm	Benign_Neck_Neoplasm|Thyroid_Neoplasm	Benign Thyroid Gland Neoplasm|Benign Neoplasm of Thyroid|Benign Neoplasm of Thyroid Gland|Benign Neoplasm of Thyroid Glands|Benign Neoplasm of the Thyroid|Benign Neoplasm of the Thyroid Gland|Benign Thyroid Gland Tumor|Benign Thyroid Neoplasm|Benign Thyroid Neoplasm NOS|Benign Thyroid Tumor|Benign Tumor of Thyroid|Benign Tumor of Thyroid Gland|Benign Tumor of the Thyroid|Benign Tumor of the Thyroid Gland|Thyroid Neoplasm, Benign	A benign neoplasm arising from the thyroid gland. --2005
C3629	Benign_Adrenal_Gland_Neoplasm	Adrenal_Gland_Neoplasm|Benign_Retroperitoneal_Neoplasm	Benign Adrenal Gland Neoplasm|Benign Adrenal Gland Tumor|Benign Adrenal Neoplasm|Benign Adrenal Tumor|Benign Neoplasm of Adrenal Gland|Benign Neoplasm of the Adrenal Gland|Benign Tumor of Adrenal Gland|Benign Tumor of the Adrenal Gland	A non-metastasizing neoplasm arising from the adrenal gland. (NCI05)
C3630	Benign_Parathyroid_Neoplasm	Benign_Neck_Neoplasm|Parathyroid_Neoplasm	Benign Parathyroid Gland Neoplasm|Benign Neoplasm of Parathyroid|Benign Neoplasm of Parathyroid Gland|Benign Neoplasm of the Parathyroid|Benign Neoplasm of the Parathyroid Gland|Benign Parathyroid Gland Tumor|Benign Parathyroid Neoplasm|Benign Parathyroid Tumor|Benign Tumor of Parathyroid|Benign Tumor of Parathyroid Gland|Benign Tumor of the Parathyroid|Benign Tumor of the Parathyroid Gland|Parathyroid Tumor Benign	A benign neoplasm arising from the parathyroid glands. (NCI05)
C3631	Benign_Pineal_Region_Neoplasm	Benign_Supratentorial_Neoplasm|Pineal_Region_Neoplasm	Benign Pineal Region Neoplasm|Benign Neoplasm of Pineal Parenchyma|Benign Neoplasm of the Pineal Parenchyma|Benign Pineal Area Neoplasm|Benign Pineal Area Tumor|Benign Pineal Parenchymal Neoplasm|Benign Pineal Parenchymal Tumor|Benign Pineal Region Tumor|Benign Tumor of Pineal Parenchyma|Benign Tumor of the Pineal Parenchyma|Pineal Parenchymal Neoplasms, Benign	A benign growth of the cells that comprise the pineal gland. Despite benign histology, symptoms can be produced due to the location: increased intracranial pressure, endocrine abnormalities, cerebellar and/or brainstem compression.(The latter can produce a constellation of symptoms known as Parinaud's syndrome.)
C3633	Intracranial_Hemangioma	Benign_Intracranial_Neoplasm|Hemangioma	Intracranial Hemangioma|Angioma of Intracranial Structure|Angioma of the Intracranial Structure|Hemangioma of Intracranial Structure|Hemangioma of the Intracranial Structure|Intracranial Angioma
C3634	Retinal_Hemangioma	Benign_Retinal_Neoplasm|Hemangioma	Retinal Hemangioma|Angioma of Retina|Angioma of the Retina|Hemangioma of Retina|Hemangioma of the Retina|Retina Angioma|Retina Hemangioma|Retinal Angioma	Abnormal growth of blood vessels within the retina without malignant characteristics.
C3635	Intra-Abdominal_Hemangioma	Hemangioma	Intra-Abdominal Hemangioma|Hemangioma of Intra-Abdominal Structure|Hemangioma, Intra-Abdominal
C3636	Benign_Lymph_Node_Neoplasm	Lymph_Node_Neoplasm	Benign Lymph Node Neoplasm|Benign Lymph Node Neoplasm NOS|Benign Lymph Node Tumor|Benign Neoplasm of Lymph Node|Benign Neoplasm of the Lymph Node|Benign Tumor of Lymph Node|Benign Tumor of the Lymph Node
C3637	Stage_0_Esophageal_Cancer	Esophageal_Carcinoma|Esophageal_High-Grade_Intraepithelial_Neoplasia|Gastrointestinal_Carcinoma_in_situ	Stage 0 Esophageal Cancer|Carcinoma in situ of Esophagus|Carcinoma in situ of the Esophagus|Esophageal Cancer Stage 0|Esophageal Carcinoma Stage 0|Esophageal Carcinoma in situ|Esophagus Carcinoma in situ|Oesophageal Carcinoma NOS Stage 0|Severe Esophageal Dysplasia|Stage 0 Carcinoma of Esophagus|Stage 0 Carcinoma of the Esophagus|Stage 0 Esophageal Carcinoma|Stage 0 Esophagus Carcinoma	Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) - 2003
C3638	Stage_0_Colon_Cancer	Colon_Carcinoma|Colorectal_High-Grade_Intraepithelial_Neoplasia|Grade_III_Glandular_Intraepithelial_Neoplasia|Stage_0_Colorectal_Cancer	Stage 0 Colon Cancer|Carcinoma in situ of Colon|Carcinoma in situ of the Colon|Colon Cancer Stage 0|Colon Carcinoma in situ|Colonic Carcinoma in situ|Stage 0 Carcinoma of Colon|Stage 0 Carcinoma of the Colon|Stage 0 Colon Carcinoma|Stage 0 Colonic Carcinoma	Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial or invasion of lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003
C3639	Tracheal_Carcinoma_in_situ	Stage_0_Squamous_Cell_Carcinoma|Tracheal_Carcinoma	Tracheal Carcinoma In Situ|Carcinoma in situ of Trachea|Carcinoma in situ of the Trachea|Severe Epithelial Dysplasia of Trachea|Trachea Carcinoma in situ
C3640	Stage_0_Skin_Cancer	Carcinoma_in_situ|Skin_Carcinoma	Stage 0 Skin Cancer|Carcinoma in situ of Skin|Carcinoma in situ of the Skin|Carcinoma of Skin Stage 0|Carcinoma of the Skin Stage 0|Cutaneous Carcinoma in situ|Skin Cancer Stage 0|Skin Carcinoma Stage 0|Skin Carcinoma in situ|Stage 0 Skin Carcinoma	Stage 0: Tis: Carcinoma in situ; N0: No regional lymph node metastasis; M0: No distant metastasis. (Based on AJCC Cancer Staging).  - 2002
C3641	Stage_0_Breast_Cancer	Breast_Carcinoma|Carcinoma_in_situ	Stage 0 Breast Cancer|Breast Cancer Stage 0|Breast Cancer in situ|Breast Carcinoma in situ|Carcinoma in situ of Breast|Carcinoma in situ of the Breast|In situ Breast Cancer|Non-Infiltrating Breast Carcinoma|Non-Infiltrating Carcinoma of Breast|Non-Infiltrating Carcinoma of the Breast|Non-Invasive Breast Carcinoma|Non-Invasive Carcinoma of Breast|Non-Invasive Carcinoma of the Breast|Stage 0 Breast Carcinoma|Stage 0 Carcinoma of Breast|Stage 0 Carcinoma of the Breast|breast cancer in situ	Abnormal cells that are confined to the ducts or lobules in the breast.  There are two forms, called ductal carcinoma in situ (DCIS) and lobular carcinoma in situ (LCIS).
C3642	Grade_III_Prostatic_Intraepithelial_Neoplasia	Grade_III_Glandular_Intraepithelial_Neoplasia|High-Grade_Prostatic_Intraepithelial_Neoplasia	Grade III Prostatic Intraepithelial Neoplasia|Adenocarcinoma in situ of Prostate|Adenocarcinoma in situ of the Prostate|Grade 3 PIN|Grade 3 Prostatic Intraepithelial Neoplasia|Grade III PIN|Prostate Adenocarcinoma in situ	This is a clonal growth of partially transformed cells resulting in morphologically identifiable premalignant lesions.  These are further subdivided into low and high-grade lesions.  The alterations include loss of glandular formation with the development of more anaplastic morphology, nuclear pleomorphism, invasion of the basement membrane, an increase in cell motility, loss of contact inhibition, and angiogenesis.
C3643	Stage_0_Penile_Cancer	Penile_Carcinoma	Stage 0 Penile Cancer|Stage 0 Carcinoma of Penis|Stage 0 Carcinoma of the Penis|Stage 0 Penile Carcinoma	Stage 0 includes: (Tis, N0, M0) and (Ta, N0, M0).  Tis: Carcinoma in situ.  Ta: Non-invasive verrucous carcinoma.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C3644	Stage_0is_Bladder_Cancer	Bladder_Flat_Intraepithelial_Lesion|High_Grade_Intraepithelial_Neoplasia|Stage_0_Bladder_Transitional_Cell_Carcinoma	Stage 0is Bladder Cancer|Bladder Flat CIS|Bladder Flat Carcinoma in Situ|Carcinoma in situ of Urinary Bladder|Carcinoma in situ of the Urinary Bladder|Flat CIS of the Bladder|Flat CIS of the Urinary Bladder|Flat Carcinoma in Situ of the Bladder|Flat Carcinoma in Situ of the Urinary Bladder|Stage 0is Bladder Carcinoma|Stage 0is Carcinoma of Bladder|Stage 0is Carcinoma of Urinary Bladder|Stage 0is Carcinoma of the Bladder|Stage 0is Carcinoma of the Urinary Bladder|Stage 0is Urinary Bladder Carcinoma|Urinary Bladder Flat CIS|Urinary Bladder Flat Carcinoma in Situ	Also known as carcinoma in situ of the urinary bladder or high grade intraurothelial neoplasia, this is a flat lesion of the transitional cell epithelium characterized by severe cytologic atypia. This lesion is confined to the urothelium, and is a precursor of invasive transitional cell carcinoma of the bladder. -- 2003
C3646	Neoplasm_of_Uncertain_Malignant_Potential	Neoplasm_by_Special_Category|Precancerous_Condition	Neoplasm of Uncertain Malignant Potential|Borderline Neoplasm|Neoplasm of Borderline Malignancy|Neoplasm of Low Malignant Potential
C3648	Cerebral_Cyst	Central_Nervous_System_Cyst	Cerebral Cyst|Cerebral Hemispheric Cyst|Cyst of Cerebral Hemispheres|Cyst of Cerebrum|Cyst of the Cerebral Hemispheres|Cyst of the Cerebrum	A fluid filled sac within the cerebrum. It is can be congenital, trauma related or secondary to another medical condition for example an infarction.
C3649	Conjunctival_Granuloma	Granuloma_by_Site	Conjunctival Granuloma|Granuloma of Conjunctiva
C3650	Conjunctival_Cyst	Cyst|Eye_and_Ear_Finding	Conjunctival Cyst|Conjunctiva Cyst|Cyst of Conjunctiva|Cyst of the Conjunctiva	Abnormal fluid filled sac within the conjunctiva.
C3651	Eyelid_Xanthoma	Benign_Cutaneous_Fibrohistiocytic_Neoplasm|Benign_Eyelid_Neoplasm|Xanthoma	Eyelid Xanthoma|Benign Eyelid Xanthelasma|Benign Xanthelasma of Eyelid|Benign Xanthelasma of the Eyelid|Xanthelasma Palpebrum|Xanthoma of Eyelid|Xanthoma of the Eyelid
C3652	Eyelid_Cyst	Cyst|Head_and_Neck_Finding	Eyelid Cyst|Cyst of Eyelid|Cyst of the Eyelid
C3653	Orbital_Granuloma	Granuloma_by_Site	Orbital Granuloma
C3654	Middle_Ear_Cholesteatoma	Cholesteatoma|Middle_Ear_Disorder|Non-Neoplastic_Ear_Disorder	Middle Ear Cholesteatoma|Cholesteatoma of Middle Ear|Cholesteatoma of the Middle Ear
C3655	Middle_Ear_Cholesterol_Granuloma	Cholesterol_Granuloma	Middle Ear Cholesterol Granuloma|Cholesterin Granuloma of Middle Ear|Cholesterol Granuloma of Middle Ear|Cholesterol Granuloma of the Middle Ear
C3656	Benign_Essential_Hypertension	Essential_Hypertension	Benign Essential Hypertension
C3657	Secondary_Hypertension	Hypertension	Secondary Hypertension
C3658	Benign_Secondary_Hypertension	Secondary_Hypertension	Benign Secondary Hypertension
C3659	Polypoid_Sinus_Degeneration	Non-Neoplastic_Paranasal_Sinus_Disorder	Polypoid Sinus Degeneration
C3660	Breast_Fibrosis	Breast_Fibrocystic_Change_Non-Proliferative_Type	Breast Fibrosis|Breast Fibrosclerosis|Fibrosclerosis of Breast|Fibrosclerosis of the Breast|Fibrosis of Breast|Fibrosis of the Breast
C3661	Breast_Fat_Necrosis	Non-Neoplastic_Breast_Disorder	Breast Fat Necrosis|Fat Necrosis of Breast|Fat Necrosis of the Breast
C3662	Uterine_Polyp	Polyp|Uterine_Disorder	Uterine Polyp|Polyp of Uterus|Polyp of the Uterus|Uterus Polyp
C3663	Vaginal_Leukoplakia	Genital_Leukoplakia	Vaginal Leukoplakia|Leukoplakia of Vagina|Leukoplakia of the Vagina
C3664	Vaginal_Polyp	Polyp|Vaginal_Non-Neoplastic_Disorder	Vaginal Polyp|Polyp of Vagina|Polyp of the Vagina
C3665	Late_Radiation_Injury	Late_Effects	Late Radiation Injury	Late radiation injury (LRI) is the damage to the soft tissue and bone following radiation therapy that occurs weeks and years after the radiation exposure. Pathogenesis of LRI stems from ischemia, interruption of the blood supply and direct cell damage. LRIs include but not limited to the skin atrophy, ulceration and non-healing wounds; cystitis, proctosigmoiditis, resulting to fistulas, abscesses, fibrosis and scaring; laryngitis, osteoradionecrosis; central nervous system injury, optic neuropathy.
C3666	Traumatic_Neuroma	Neuroma	Traumatic Neuroma
C3667	Thyroid_Cyst	Cyst|Endocrine_System_Finding	Thyroid Cyst|Cyst of Thyroid|Cyst of Thyroid Gland|Cyst of the Thyroid|Cyst of the Thyroid Gland|Thyroid Gland Cyst	Abnormal fluid filled sac within the thyroid gland.
C3668	Contact_Hypersensitivity	Hypersensitivity	Contact Hypersensitivity	Contact hypersensitivity is an inflammatory response induced by antigen-reactive T cells that are exposed to antigen on the skin surface (epidermis).  Poison ivy is a frequent cause of such reactivity, due to the urushiol from the plant, as are a variety of antigens derived from industrial exposure (e.g. rubber, chromate, nickel).  These antigens induce the appearance of Th1-like T cells, which presumably produce IFN to activate macrophages.
C3669	Malnutrition	Nutritional_Disorder	Malnutrition|malnutrition	A disorder caused by a lack of proper nutrition or an inability to absorb nutrients from food.
C3670	Parapsoriasis_en_Plaques	Large_Plaque_Parapsoriasis	Parapsoriasis en Plaques
C3671	Injury	Finding_by_Cause	Injury|Trauma|WND|Wound	Damage inflicted on the body as the direct or indirect result of an external force, with or without disruption of structural continuity.
C3672	Calcification	Deposit	Calcification|CALC|calcification	Deposition of calcium in the tissues.  It may be the result of a metabolic disorder or long-standing infection, or it may be associated with the presence of cancer. -- 2004
C3673	Anhedonia	Psychiatric_Disorder	Anhedonia
C3674	Reproductive_System_Neoplasm	Neoplasm_by_Site|Reproductive_System_Disorder	Reproductive System Neoplasm|Neoplasm of Reproductive System|Neoplasm of the Reproductive System|Reproductive Neoplasm|Reproductive System Tumor|Reproductive Tumor|Tumor of Reproductive System|Tumor of the Reproductive System	Includes both malignant and benign neoplasms of the male and female reproductive tracts
C3675	Obstructive_Uropathy	Urinary_Tract_Disorder	Obstructive Uropathy
C3676	Alteration_in_Respiration	Ventilation_or_Perfusion_Signs_and_Symptoms	Alteration in Respiration
C3677	Benign_Neoplasm	Neoplasm_by_Special_Category	Benign Neoplasm|Benign Tumor|benign tumor	(beh-NINE) A noncancerous growth that does not invade nearby tissue or spread to other parts of the body.
C3678	Salivary_Gland_Basal_Cell_Adenocarcinoma	Malignant_Basal_Cell_Neoplasm|Salivary_Gland_Adenocarcinoma	Salivary Gland Basal Cell Adenocarcinoma|Basal Cell Adenocarcinoma|Basal Cell Adenocarcinoma of Salivary Gland|Basal Cell Adenocarcinoma of the Salivary Gland	A rare adenocarcinoma of the major and minor salivary glands, originating from basaloid, myoepithelial and ductal cells.  While morphologically resembling basal cell carcinomas, it is a distinct entity.  The tumor is not encapsulated, may invade locally, and less frequently may metastasize.  It usually occurs in older patients.
C3679	Oxyphilic_Adenocarcinoma	Adenocarcinoma	Oxyphilic Adenocarcinoma|Hurthle Cell Adenocarcinoma|Hurthle Cell Carcinoma|Oncocytic Adenocarcinoma|Oncocytic Carcinoma
C3680	Cribriform_Carcinoma	Carcinoma	Cribriform Carcinoma
C3681	Granular_Cell_Carcinoma	Adenocarcinoma	Granular Cell Carcinoma|Granular Cell Adenocarcinoma
C3682	Tubular_Adenocarcinoma	Adenocarcinoma	Tubular Adenocarcinoma|Tubular Carcinoma
C3683	Basal_Cell_Adenoma	Retired_Concepts	Basal Cell Adenoma
C3684	Thyroid_Follicular_Adenoma	Retired_Concepts	Thyroid Gland Follicular Adenoma|Follicular Adenoma|Follicular Adenoma of Thyroid|Follicular Adenoma of Thyroid Gland|Follicular Adenoma of the Thyroid|Follicular Adenoma of the Thyroid Gland|Thyroid Follicular Adenoma
C3685	Microcystic_Adenoma	Adenoma	Microcystic Adenoma
C3686	Salivary_Gland_Monomorphic_Adenoma	Adenoma|Benign_Salivary_Gland_Neoplasm	Salivary Gland Monomorphic Adenoma
C3687	Papillary_Adenoma	Renal_Adenoma	Renal Papillary Adenoma|Chromophil Adenoma of the Kidney|Papillary Adenoma of the Kidney	A controversial term, used for renal papillary lesions which measure 1cm or less in diameter and contain small, regular nuclei. -- 2003
C3688	Trabecular_Adenoma	Adenoma	Trabecular Adenoma
C3689	Goblet_Cell_Carcinoid_Tumor	Appendix_Mixed_Endocrine-Exocrine_Neoplasm	Appendix Goblet Cell Carcinoid Tumor|Goblet Cell Carcinoid Neoplasm|Goblet Cell Carcinoid Tumor|Mucinous Carcinoid Neoplasm|Mucinous Carcinoid Tumor
C3690	Anaplastic_Carcinoma	Retired_Concepts	Anaplastic Carcinoma
C3692	Undifferentiated_Carcinoma	Carcinoma	Undifferentiated Carcinoma|Anaplastic Carcinoma|Carcinoma, Undifferentiated
C3693	Carcinomatosis	Metastatic_Carcinoma	Carcinomatosis|carcinomatosis	A condition in which cancer is spread widely throughout the body.
C3694	Dysplastic_Nevus	Cutaneous_Precancerous_Condition|Melanocytic_Nevus	Dysplastic Nevus|Atypical Nevus|Clark's Nevus|Lentiginous Nevus|NAD|Nevus with Architectural Disorder and Cytologic Atypia of Melanocytes|dysplastic nevi|dysplastic nevus	(dis-PLAS-tik NEE-vus) An atypical mole; a mole whose appearance is different from that of a common mole. A dysplastic nevus is generally larger than an ordinary mole and has irregular and indistinct borders. Its color frequently is not uniform and ranges from pink to dark brown; it is usually flat, but parts may be raised above the skin surface.
C3695	Papillary_Fibroelastoma	Benign_Endocardial_Neoplasm	Papillary Fibroelastoma|Fibroelastic Papilloma|Giant Lambl Excrescence
C3696	Subependymal_Giant_Cell_Astrocytoma	Subependymal_Astrocytoma	Subependymal Giant Cell Astrocytoma|SEGA|Subependymal Giant Cell Astrocytic Neoplasm|Subependymal Giant Cell Astrocytic Tumor	Subependymal Giant Cell Astrocytoma is a benign, slowly growing tumor (WHO grade I) typically arising in the wall of the lateral ventricles and composed of large ganglioid astrocytes. It is the most common CNS neoplasm in patients with Tuberous Sclerosis Complex and typically occurs during the first two decades of life. (WHO)
C3697	Myxopapillary_Ependymoma	Ependymal_Tumor	Myxopapillary Ependymoma	Myxopapillary Ependymomas (WHO grade I) are slow growing gliomas which generally occur in young adults and arise almost exclusively in the conus-cauda-filum terminale region. It generally has a favorable prognosis and is characterized histologically by tumor cells arranged in a papillary manner around vascularized mucoid stromal cores. (Adapted from WHO.)
C3698	Choroid_Plexus_Papilloma	Benign_Choroid_Plexus_Neoplasm|Papilloma	Choroid Plexus Papilloma|Papilloma of Choroid Plexus|Papilloma of the Choroid Plexus	Choroid Plexus Papilloma (WHO grade I) is a benign, slow growing tumor which may cause symptoms by blocking CSF pathways. Surgical resection is usually curative. (Adapted from WHO.)
C3699	Intramuscular_Hemangioma	Deep_Hemangioma	Intramuscular Hemangioma|Intramuscular Angioma
C3700	Epithelioid_Leiomyosarcoma	Leiomyosarcoma|Sarcoma_Differentiation_Score_3	Epithelioid Leiomyosarcoma	A leiomyosarcoma with a predominance of epithelioid-type cells. -- 2003
C3701	Myxoid_Leiomyosarcoma	Leiomyosarcoma	Myxoid Leiomyosarcoma	A rare, highly aggressive variant of leiomyosarcoma, most frequently seen in the uterus and the gastrointestinal tract. -- 2003
C3702	Hibernoma	Benign_Lipomatous_Neoplasm	Hibernoma|Brown Fat Neoplasm|Brown Fat Tumor|Fetal Fat Cell Lipoma	Hibernoma is a lipoma that originates from brown fat and is composed of uniform granular or multi-vacuolated cells with small, centrally placed nuclei. (WHO)
C3703	Pleomorphic_Lipoma	Spindle_Cell_Pleomorphic_Lipoma	Pleomorphic Lipoma	A lipoma with prominent vascularity.  The vascular tissue is more abundant at the periphery of the tumor.  It occurs more frequently in younger individuals as a painful subcutaneous nodule, often on the arms. -- 2003
C3704	Dedifferentiated_Liposarcoma	Liposarcoma|Sarcoma_Differentiation_Score_3	Dedifferentiated Liposarcoma
C3705	Pleomorphic_Liposarcoma	Liposarcoma|Sarcoma_Differentiation_Score_3|Sarcoma_NCI_Grade_3	Pleomorphic Liposarcoma	A liposarcoma with areas of pleomorphism, resembling malignant fibrous histiocytoma. -- 2003
C3706	Medullomyoblastoma	Medulloblastoma	Medullomyoblastoma	Medullomyoblastoma (WHO grade IV) is a rare embryonal cerebellar neoplasm with both a primitive neuroectodermal and striated muscle component. Histologically, it is a medulloblastoma with focal myogenic differentiation. (Adapted from WHO.)
C3707	Meningiomatosis	Meningioma	Meningiomatosis|Meningiomas, Multiple
C3708	Germ_Cell_Neoplasm	Neoplasm_by_Morphology	Germ Cell Tumor|Germ Cell Neoplasm|Germ Cell Neoplasms|Neoplasm of Germ Cell|Neoplasm of the Germ Cell|Tumor of Germ Cell|Tumor of the Germ Cell|germ cell tumor	A type of tumor that begins in the cells that give rise to sperm or eggs. Germ cell tumors can occur almost anywhere in the body and can be either benign or malignant.
C3709	Epithelial_Neoplasm	Neoplasm_by_Morphology	Epithelial Neoplasm|Epithelial Neoplasms, NOS
C3710	Ameloblastic_Fibro-Odontoma	Odontoma	Ameloblastic Fibro-Odontoma|Ameloblastic Fibroodontoma|Fibroameloblastic Odontoma
C3711	Compound_Odontoma	Odontoma	Compound Odontoma
C3712	Squamous_Cell_Papilloma	Benign_Squamous_Cell_Neoplasm|Papilloma	Squamous Papilloma|Epidermoid Cell Papilloma|Epidermoid Papilloma|Keratotic Papilloma|Squamous Cell Papilloma
C3713	Papillomatosis	Papillary_Epithelial_Neoplasm	Papillomatosis
C3714	Epithelioid_Sarcoma	Malignant_Miscellaneous_Mesenchymal_Neoplasm|Sarcoma_Differentiation_Score_3	Epithelioid Sarcoma|Epithelioid Cell Sarcoma
C3715	AIDS_Encephalopathy	Diseases_Associated_with_AIDS	AIDS Encephalopathy
C3716	Neuroectodermal_Tumor	Neuroepithelial_Neoplasm	Primitive Neuroectodermal Tumor|Neuroectodermal Neoplasm|Neuroectodermal Tumor|Neuroepithelioma|PNET|Primitive Neuroectodermal Neoplasm|neuroectodermal tumor	A malignant neoplasm that originates in the neuroectoderm. The neuroectoderm constitutes the portion of the ectoderm of the early embryo that gives rise to the central and peripheral nervous systems and includes some glial cell precursors. --2004
C3717	Infantile_Melanotic_Neuroectodermal_Neoplasm	Central_Nervous_System_Primitive_Neuroectodermal_Tumor	Infantile Melanotic Neuroectodermal Neoplasm|Melanotic Neuroectodermal Tumor of Infancy|Pigmented Neuroectodermal Tumor of Infancy|Retinal Anlage Neoplasm
C3718	Wilms_Tumor-Aniridia-Genitourinary_Anomalies-Mental_Retardation_Syndrome	Hereditary_Neoplastic_Syndrome	Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation Syndrome|WAGR Syndrome	A very rare congenital condition involving the complex of Wilms' tumor, aniridia, genitourinary abnormalities, and mental retardation. Wilms Tumor-Aniridia-Genitourinary Anomalies-Mental Retardation (WAGR) syndrome involves hemizygous deletions of several adjacent genes in chromosome region 11p13. Two or more of the four conditions must be present for an individual to be diagnosed with WAGR Syndrome. The clinical picture varies, depending upon the combination of abnormalities. --2004
C3720	Anaplastic_Large_Cell_Lymphoma	Anaplastic_Malignant_Neoplasm|Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Anaplastic Large Cell Lymphoma|ALCL|CD30 Positive Anaplastic Large Cell Lymphoma|Ki-1 Lymphoma|Ki-1+ ALCL|Ki-1+ Anaplastic Large Cell Lymphoma|anaplastic large cell lymphoma	A peripheral (mature) T-cell lymphoma, consisting of usually large anaplastic, CD30 positive cells.  Majority of cases are positive for the anaplastic large cell lymphoma (ALK) protein.  The most frequently seen genetic alteration is a t(2;5) translocation.  Majority of patients present with advanced disease.  The most important prognostic indicator is ALK positivity, which has been associated with a favorable prognosis. (WHO, 2001) -- 2003
C3721	Lymphomatoid_Papulosis	Cutaneous_Mature_T-Cell_and_NK-Cell_Neoplasm|Cutaneous_Precancerous_Condition|T-Cell_Proliferation_of_Uncertain_Malignant_Potential	Lymphomatoid Papulosis|LyP	This is a chronic, recurrent skin disease characterized by spontaneously regressing papules composed of an atypical CD30-positive T-cell population.  The disease is defined as an atypical lymphoproliferative process and usually has a benign course.  However, a minority of cases are clonal and can progress to frank lymphoma.  Low dose methotrexate and psoralen/UVA (PUVA) are the best available therapies.  (WHO, 2001) -- 2003
C3722	Oral_Cavity_Hairy_Leukoplakia	Diseases_Associated_with_AIDS|Oral_Cavity_Leukoplakia	Oral Cavity Hairy Leukoplakia|Hairy Leukoplakia of Mouth|Hairy Leukoplakia of Oral Mucosa|Hairy Leukoplakia of the Mouth|Hairy Leukoplakia of the Oral Mucosa|Mouth Hairy Leukoplakia|Oral Hairy Keratosis	An epithelial hyperplasia of the oral mucosa associated with Epstein-Barr virus and found almost exclusively in persons with HIV infection. The lesion consists of a white patch that is often corrugated or hairy. --2004
C3723	Lymphatic_Vessel_Neoplasm	Vascular_Neoplasm	Lymphatic Vessel Neoplasm|Lymph Vessel Neoplasm|Lymph Vessel Tumor|Lymphatic Vessel Tumor|Neoplasm of Lymph Vessel|Neoplasm of Lymphatic Vessel|Neoplasm of the Lymph Vessel|Neoplasm of the Lymphatic Vessel|Tumor of Lymph Vessel|Tumor of Lymphatic Vessel|Tumor of the Lymph Vessel|Tumor of the Lymphatic Vessel
C3724	Cystic_Lymphangioma	Lymphangioma	Cystic Hygroma|Cystic Lymphangioma	A lymphangioma of the neck
C3725	Lymphangiomyomatosis	Neoplasm_with_Perivascular_Epithelioid_Cell_Differentiation	Lymphangioleiomyomatosis|Lymphangiomyomatosis
C3726	Adenomyoma	Mixed_Mesodermal_Mullerian_Tumor	Adenomyoma
C3727	Adenosquamous_Carcinoma	Carcinoma|Complex_Epithelial_Neoplasm	Adenosquamous Carcinoma|Mixed Adenocarcinoma and Epidermoid Carcinoma|Mixed Adenocarcinoma and Epidermoid Cell Carcinoma|Mixed Adenocarcinoma and Squamous Carcinoma|Mixed Adenocarcinoma and Squamous Cell Carcinoma
C3728	Hepatoblastoma	Childhood_Liver_Cancer|Complex_Epithelial_Neoplasm|Embryonal_Neoplasm	Hepatoblastoma|HBL|Pediatric Embryonal Hepatoma|Pediatric Hepatoblastoma|hepatoblastoma	(HEP-a-toe-blas-TOE-ma) A type of liver tumor that occurs in infants and children.
C3729	Malignant_Mixed_Neoplasm	Mixed_Neoplasm	Malignant Mixed Neoplasm|Malignant Mixed Tumor
C3730	Mixed_Mesodermal_Mullerian_Tumor	Endometrioid_Tumor|Mixed_Neoplasm	Mixed Mesodermal (Mullerian) Tumor|Mixed Mesodermal (Mullerian) Neoplasm|Mixed Mullerian Tumor	A group of tumors affecting the female reproductive system, characterised by the presence of epithelial and stromal elements.  It includes the following clinicopathological entities: adenofibroma, adenomyoma, mullerian adenosarcoma, and malignant mixed mesodermal (mullerian) tumor.
C3731	Mesoblastic_Nephroma	Embryonal_Neoplasm|Renal_Neoplasm|Spindle_Cell_Neoplasm	Mesoblastic Nephroma
C3732	Pulmonary_Blastoma	Blastoma|Lung_Sarcomatoid_Carcinoma	Pulmonary Blastoma|Blastoma of Lung|Blastoma of the Lung|Lung Blastoma|Pneumoblastoma	A malignant neoplasm of the lung composed of tubular structures and immature mesenchymal elements, which may differentiate towards skeletal and smooth muscle, cartilage or a combination of muscle and cartilage.  This is a nodular tumor found in the periphery of the lung.  It can occur at any age.  The prognosis is related to the stage of the disease at the time of resection.  Pulmonary blastoma is divided into three subtypes: epithelial predominant, biphasic, and pleuropulmonary blastoma. --2003
C3733	Angiolipoma	Benign_Lipomatous_Neoplasm	Angiolipoma	A lipoma with prominent vascularity.  The vascular tissue is more abundant at the periphery of the tumor.  It occurs more frequently in younger individuals as a painful subcutaneous nodule, often on the arms. -- 2003
C3734	Angiomyolipoma	Neoplasm_with_Perivascular_Epithelioid_Cell_Differentiation	Angiomyolipoma
C3735	Myxoid_Liposarcoma	Myxoid_Round_Cell_Liposarcoma|Sarcoma_Differentiation_Score_2|Sarcoma_NCI_Grade_1	Myxoid Liposarcoma	The most common type of liposarcoma.  It is composed of small, uniform cells and a rich network of capillaries in a myxoid stroma. -- 2003
C3736	Myelolipoma	Adrenal_Gland_Disorder|Soft_Tissue_Disorder	Adrenal Gland Myelolipoma|Myelolipoma	A benign soft tissue lesion arising from the adrenal gland.  It is composed of mature adipose and hematopoietic/lymphoid tissues. (NCI05)
C3737	Mesenchymal_Chondrosarcoma	Chondrosarcoma|Sarcoma_Differentiation_Score_3|Sarcoma_NCI_Grade_3	Mesenchymal Chondrosarcoma
C3738	Giant_Cell_Tumor_of_Bone	Bone_Neoplasm|Giant_Cell_Tumor|Neoplasm_of_Uncertain_Histogenesis	Giant Cell Tumor of Bone|Bone Giant Cell Neoplasm|Bone Giant Cell Tumor|Giant Cell Neoplasm of Bone
C3739	Benign_Fibrous_Histiocytoma	Benign_Fibrohistiocytic_Neoplasm|Common_Connective_and_Soft_Tissue_Neoplasm|Histiocytoma	Benign Fibrous Histiocytoma|Fibrous Histiocytoma	A benign neoplasm composed of fibroblasts and histiocytes.  Most commonly this tumor is found in the skin and superficial subcutaneous tissues.  Less frequently it can be found in deep soft tissues. -- 2003
C3740	Bone_Desmoplastic_Fibroma	Benign_Bone_Neoplasm|Fibroma	Bone Desmoplastic Fibroma|Desmoplastic Fibroma|Desmoplastic Fibroma of Bone|Desmoplastic Fibroma of the Bone|Osseous Desmoplastic Fibroma
C3741	Abdominal_Fibromatosis	Deep_Fibromatosis_Desmoid_Tumor	Abdominal Fibromatosis|Abdominal Desmoid|Abdominal Desmoid Tumor|Intraabdominal Desmoid|Intraabdominal Desmoid Tumor|Intraabdominal Fibromatosis|Mesenteric Desmoid|Mesenteric Desmoid Tumor|Mesenteric Fibromatosis
C3742	Myofibromatosis	Benign_Fibrous_Soft_Tissue_Neoplasm	Myofibromatosis
C3743	Fibroepithelial_Neoplasm	Mixed_Neoplasm	Fibroepithelial Neoplasm|Fibroepithelial Tumor
C3744	Fibroadenoma	Breast_Fibroepithelial_Neoplasm|Non-Proliferating_Breast_Lesion	Fibroadenoma|Breast Fibroadenoma|Fibroadenoma of Breast|Fibroadenoma of the Breast	This is the most common benign breast lesion.  It usually occurs in premenopausal women.  Diagnostic exams and procedures include: clinical exam, imaging (mammography and ultra sound), and tissue biopsy (fine-needle aspiration or core biopsy). -2002
C3745	Clear_Cell_Sarcoma_of_Soft_Parts	Neoplasm_of_Uncertain_Histogenesis	Clear Cell Sarcoma of Soft Parts|Malignant Melanoma of Soft Parts|Malignant Melanoma of the Soft Parts	A rare malignant neoplasm with melanocytic differentiation characterized by the presence of polygonal or spindle shaped clear cells. This sarcoma usually affects the tendons and aponeuroses and is associated with a poor prognosis due to recurrences and metastases.
C3746	Small_Cell_Sarcoma	Sarcoma_of_the_Soft_Tissue_and_Bone	Small Cell Sarcoma|Small Cell Sarcomas
C3747	Angiomyoma	Leiomyoma	Angiomyoma|Angioleiomyoma|Vascular Leiomyoma	A vascular leiomyoma characterized by thick-walled arteries or veins. -- 2003
C3748	Leiomyomatosis	Leiomyoma	Leiomyomatosis	Leiomyomas in multiple anatomic sites. -- 2003
C3749	Alveolar_Rhabdomyosarcoma	Rhabdomyosarcoma|Sarcoma_Differentiation_Score_3	Alveolar Rhabdomyosarcoma
C3750	Alveolar_Soft_Part_Sarcoma	Malignant_Miscellaneous_Mesenchymal_Neoplasm|Sarcoma_Differentiation_Score_3|Sarcoma_NCI_Grade_3	Alveolar Soft Part Sarcoma
C3751	Smooth_Muscle_Neoplasm	Myomatous_Neoplasm	Smooth Muscle Neoplasm|Neoplasm of Smooth Muscle|Neoplasm of the Smooth Muscle|Smooth Muscle Tumor|Tumor of Smooth Muscle|Tumor of the Smooth Muscle	A benign or malignant myomatous neoplasm arising from smooth muscle. -- 2003
C3752	Embryonal_Carcinoma	Carcinoma|Malignant_Germ_Cell_Neoplasm	Embryonal Carcinoma
C3753	Germinoma	Malignant_Germ_Cell_Neoplasm	Germinoma|germinoma	(jer-mih-NO-ma) The most common type of germ cell tumor in the brain.
C3754	Gonadoblastoma	Mixed_Germ_Cell-Sex_Cord-Stromal_Tumor	Gonadoblastoma
C3756	Mixed_Embryonal_Carcinoma_and_Teratoma	Mixed_Germ_Cell_Neoplasm	Mixed Embryonal Carcinoma and Teratoma|Teratocarcinoma	This tumor is made up of derivatives of more than one of the three primary germ cell layers (endoderm, mesoderm, or ectoderm).
C3757	Placental-Site_Gestational_Trophoblastic_Tumor	Gestational_Trophoblastic_Tumor|Placental_Neoplasm	Placental-Site Gestational Trophoblastic Tumor|Placental Site Gestational Trophoblastic Tumor|Placental-Site GTT|Placental-Site Gestational Trophoblastic Neoplasm
C3758	Hepatocellular_Adenoma	Adenoma|Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Hepatic_Disorder|Hepato-Biliary_Precancerous_Condition	Hepatocellular Adenoma|Adenoma of Liver Cells|Adenoma of the Liver Cells|HCA|Liver Cell Adenoma
C3759	Oxyphilic_Adenoma	Adenoma|Oncocytic_Neoplasm	Oncocytic Adenoma|Oxyphilic Adenoma	A benign neoplasm composed of large cells with abundant eosinophilic granular cytoplasm.  Representative examples include oncocytic adenomas of the thyroid gland, parathyroid gland, and pituitary gland.(NCI05)
C3760	Hidrocystoma	Sweat_Gland_Adenoma	Hidrocystoma|Hydrocystoma
C3761	Syringoma	Benign_Eccrine_Neoplasm	Eccrine Syringoma|Syringoma
C3762	Adenomatoid_Tumor	Mesothelioma	Adenomatoid Tumor|Benign Localized Epithelial Mesothelioma|Benign Mesothelial Neoplasm|Benign Mesothelial Tumor|Benign Mesothelioma|Benign Neoplasm of Mesothelium|Benign Neoplasm of the Mesothelium|Benign Tumor of Mesothelium|Benign Tumor of the Mesothelium|Mesothelioma, Benign
C3763	Pulmonary_Adenomatosis	Lung_Adenoma	Pulmonary Adenomatosis
C3764	Adenomatous_Polyp	Adenoma|Neoplastic_Polyp	Adenomatous Polyp|Polypoid Adenoma	polyp consisting of benign neoplastic tissue derived from glandular epithelium.
C3765	Cystic_Mesothelioma	Mesothelioma|Neoplasm_of_Uncertain_Malignant_Potential	Cystic Mesothelioma|Intermediate Mesothelioma
C3766	Clear_Cell_Adenocarcinoma	Adenocarcinoma	Clear Cell Adenocarcinoma|Clear Cell Carcinoma|Mesonephroid Clear Cell Adenocarcinoma|Mesonephroid Clear Cell Carcinoma|clear cell carcinoma	(kar-sin-O-ma) A rare type of tumor of the female genital tract in which the inside of the cells looks clear when viewed under a microscope.
C3767	Sebaceous_Adenocarcinoma	Retired_Concepts	Sebaceous Adenocarcinoma
C3768	Acinar_Cell_Carcinoma	Acinar_Cell_Neoplasm|Adenocarcinoma	Acinar Cell Carcinoma|Acinar Adenocarcinoma|Acinar Carcinoma|Acinar Cell Adenocarcinoma|Acinic Cell Adenocarcinoma|Acinic Cell Carcinoma
C3769	Endometrioid_Carcinoma	Adenocarcinoma|Endometrioid_Tumor|Malignant_Female_Reproductive_System_Neoplasm	Endometrioid Adenocarcinoma|Endometrioid Carcinoma|Endometrioid Carcinoma of Female Reproductive System|Endometrioid Carcinoma of the Female Reproductive System|Female Reproductive Endometrioid Carcinoma
C3770	Pancreatic_Endocrine_Carcinoma	Malignant_Pancreatic_Neoplasm|Neuroendocrine_Carcinoma|Pancreatic_Endocrine_Neoplasm	Pancreatic Endocrine Carcinoma|Islet Cell Cancer|Islet Cell Carcinoma|Malignant Islet Cell Tumor|Malignant Pancreatic Endocrine Tumor|Pancreatic Neuroendocrine Carcinoma|islet cell cancer	(EYE-let) Cancer arising from cells in the islets of Langerhans, which are found in the pancreas.  Also called endocrine cancer.
C3771	Lobular_Breast_Carcinoma	Breast_Adenocarcinoma	Lobular Breast Carcinoma|Lobular Adenocarcinoma|Lobular Carcinoma|Lobular Carcinoma of Breast|Lobular Carcinoma of the Breast	An adenocarcinoma of the breast arising from the lobules.  This is a relatively uncommon carcinoma, represents approximately 10% of the breast adenocarcinomas and is often bilateral or multifocal. --2002
C3772	Mucoepidermoid_Carcinoma	Mucin-Secreting_Carcinoma	Mucoepidermoid Carcinoma|MEC
C3773	Neuroendocrine_Carcinoma	Carcinoma|Malignant_Endocrine_Neoplasm|Neuroendocrine_Neoplasm	Neuroendocrine Carcinoma	A malignant neuroendocrine tumor composed of cells containing secretory granules that stain positive for NSE and chromogranin.  Tumor cells are often round and form clusters or trabecular sheets.  Representative examples are carcinoid tumor, small cell carcinoma, and Merkel cell carcinoma. -- 2004
C3774	Signet_Ring_Cell_Carcinoma	Adenocarcinoma	Signet Ring Cell Carcinoma|Signet Ring Cell Adenocarcinoma|signet ring cell carcinoma	A highly malignant type of cancer typically found in glandular cells that line the digestive organs. The cells resemble signet rings when examined under a microscope.
C3775	Adnexal_Carcinoma	Malignant_Skin_Appendage_Neoplasm|Skin_Carcinoma	Adnexal Carcinoma|Carcinoma of Adnexa|Carcinoma of Skin Appendage|Skin Appendage Carcinoma
C3776	Mucinous_Cystadenocarcinoma	Cystadenocarcinoma|Mucinous_Adenocarcinoma	Mucinous Cystadenocarcinoma|Pseudomucinous Adenocarcinoma|Pseudomucinous Cystadenocarcinoma
C3777	Papillary_Cystadenocarcinoma	Cystadenocarcinoma|Papillary_Adenocarcinoma	Papillary Cystadenocarcinoma
C3778	Serous_Cystadenocarcinoma	Cystadenocarcinoma|Serous_Neoplasm	Serous Cystadenocarcinoma|Serous Adenocarcinoma
C3779	Giant_Cell_Carcinoma	Carcinoma|Malignant_Giant_Cell_Neoplasm	Giant Cell Carcinoma|Carcinoma, Giant Cell
C3780	Large_Cell_Carcinoma	Carcinoma	Large Cell Carcinoma|Carcinoma, Large Cell|large cell carcinomas	(kar-sin-O-mas) A group of lung cancers in which the cells are large and look abnormal when viewed under a microscope.
C3781	Verrucous_Carcinoma	Squamous_Cell_Carcinoma	Verrucous Carcinoma|Verrucous Epidermoid Carcinoma|Verrucous Epidermoid Cell Carcinoma|Verrucous Squamous Carcinoma|Verrucous Squamous Cell Carcinoma
C3782	Cervical_Intraepithelial_Neoplasia	Cervical_Neoplasm|Female_Reproductive_System_Precancerous_Condition|Intraepithelial_Neoplasia	Cervical Intraepithelial Neoplasia|Cervical Dysplasia|Cervix Intraepithelial Neoplasia|Cervix Uteri Intraepithelial Neoplasia|Intraepithelial Neoplasia of Cervix|Intraepithelial Neoplasia of Cervix Uteri|Intraepithelial Neoplasia of Uterine Cervix|Intraepithelial Neoplasia of the Cervix|Intraepithelial Neoplasia of the Cervix Uteri|Intraepithelial Neoplasia of the Uterine Cervix|Uterine Cervix Intraepithelial Neoplasia|cervical intraepithelial neoplasia	A general term for the abnormal growth of squamous or glandular cells on the surface of the cervix. There are two types of cervical intraepithelial neoplasia: cervical squamous and cervical glandular intraepithelial neoplasia.  The changes in the cells are described as low grade or high grade, depending on how much of the cervix is affected and how abnormal the cells are.
C3783	Serous_Cystadenoma	Cystadenoma|Serous_Neoplasm	Serous Cystadenoma|Serous Cystoma
C3784	Basal_Cell_Neoplasm	Epithelial_Neoplasm	Basal Cell Neoplasm|Basal Cell Tumor	A neoplastic proliferation of basal cells in the epidermis (part of the skin) or other anatomic sites (most frequently the salivary glands).  The basal cell neoplastic proliferation in the epidermis results in basal cell carcinomas.  The basal cell neoplastic proliferation in the salivary glands can be benign, resulting in basal cell adenomas or malignant, resulting in basal cell adenocarcinomas. --2003
C3785	Intraductal_Papilloma	Papilloma	Intraductal Papilloma|Duct Adenoma|Ductal Papilloma
C3786	Mesothelial_Neoplasm	Neoplasm_by_Morphology	Mesothelial Neoplasm|Mesothelial Tumor	A benign or malignant neoplasm arising from mesothelial cells.  Mesothelial cells are the lining cells of the pleura and peritoneum. -- 2003
C3787	Neuroepithelial_Neoplasm	Neuroepithelial_Perineurial_and_Schwann_Cell_Neoplasm	Neuroepithelial Neoplasm|Neoplasm of Neuroepithelial Tissue|Neoplasm of Neuroepithelium|Neoplasm of the Neuroepithelium|Neuroepithelial Neoplasms|Neuroepithelial Tissue Neoplasm|Neuroepithelial Tissue Tumor|Neuroepithelial Tumor|Neuroepithelial Tumors|Tumor of Neuroepithelial Tissue|Tumor of Neuroepithelium|Tumor of the Neuroepithelium
C3788	Ganglioglioma	Neuronal_and_Mixed_Neuronal-Glial_Tumor	Ganglioglioma	Ganglioglioma (WHO grade I or II) and Gangliocytoma (WHO grade I) are well differentiated, slow growing neuroepithelial neoplasms composed of neoplastic, mature ganglion cells either alone (gangliocytoma), or in combination with neoplastic glial cells (ganglioglioma). Some Gangliogliomas show anaplastic features in their glial component and are considered to be WHO grade III (see 'Anaplastic Ganglioglioma). There are rare cases of newly diagnosed Gangliogliomas with grade IV (Glioblastoma) changes in the glial component. (Adapted from WHO.)
C3789	Olfactory_Neuroblastoma	Extracranial_Neuroblastoma|Malignant_Olfactory_Nerve_Neoplasm	Olfactory Neuroblastoma|Esthesioneuroblastoma|Esthesioneuroepithelioma|Olfactory Esthesioneuroblastoma|Olfactory Neuroepithelioma	Olfactory Neuroblastomas are rare neuroectodermal tumors. They are assumed to originate from olfactory receptor cells high in the nasal cavity. Unless resected at an early stage, they carry a poor prognosis. Microscopically, their typical pattern is neuroblastic with occasional formation of rosettes, but some lesions show neuroendocrine differentiation. When this pattern dominates the histology, the diagnosis of a neuro-endocrine carcinoma may occur. (Adapted from WHO.)
C3790	Ganglioneuroblastoma	Neuroblastic_Tumor	Ganglioneuroblastoma	Ganglioneuroblastoma is a type of Neuroblastic Tumor. There are two subtypes: Ganglioneuroblastoma, intermixed (Schwannian stroma-rich) and Ganglioneuroblastoma, nodular (composite, Schwannian stroma-rich/stroma-dominant and stroma-poor). (Adapted from WHO.)
C3791	Neurocytoma	Intraventricular_Brain_Neoplasm|Neuronal_and_Mixed_Neuronal-Glial_Tumor	Central Neurocytoma	Central Neurocytoma is an intraventricular neuronal neoplasm composed of uniform round cells with neuronal differentiation. It is typically located in the lateral ventricles in the region of the foramen of Monro.  It generally affects young adults and has a favorable prognosis. (Adapted from WHO.)
C3792	Squamous_Cell_Neoplasm	Epithelial_Neoplasm	Squamous Cell Neoplasm|Epidermoid Cell Neoplasm|Epidermoid Cell Tumor|Squamous Cell Tumor
C3793	Inverted_Papilloma	Papilloma	Inverted Papilloma
C3794	Sex_Cord-Stromal_Tumor	Reproductive_Endocrine_Neoplasm|Reproductive_System_Neoplasm	Sex Cord-Stromal Tumor|Neoplasm of Sex Cord|Neoplasm of the Sex Cord|Sex Cord Neoplasm|Sex Cord Tumor|Sex Cord-Stromal Neoplasm|Specialized Gonadal Neoplasm|Specialized Gonadal Tumor|Tumor of Sex Cord|Tumor of the Sex Cord
C3795	Subependymoma	Ependymal_Tumor	Subependymoma|Subependymal Glioma|WHO Grade I Ependymal Neoplasm|WHO Grade I Ependymal Tumor	Subependymoma (WHO grade I) is a benign, slow growing neoplasm which is typically attached to a ventricular wall. It is composed of glial tumor cell clusters embedded in an abundant fibrillary matrix with frequent microcystic change. Some lesions have the histological features of both subependymoma and ependymoma. It is often detected incidentally and has a very favorable prognosis. (Adapted from WHO.)
C3796	Gliosarcoma	Glioblastoma	Gliosarcoma|Glioblastoma with a Sarcomatous Component|gliosarcoma	A rare histological variant of Glioblastoma (WHO grade IV) characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation. (WHO) It is associated with the molecular abnormalities seen in primary and secondary glioblastomas, except for the amplification of EGFR. -- 2004
C3797	Plexiform_Neurofibroma	Neurofibroma	Plexiform Neurofibroma|plexiform neurofibroma	A nerve that has become thick and misshapen due to the abnormal growth of cells and tissues that cover the nerve.
C3798	Malignant_Peripheral_Nerve_Sheath_Tumor	Malignant_Peripheral_Nervous_System_Neoplasm|Peripheral_Nerve_Sheath_Neoplasm	Malignant Peripheral Nerve Sheath Tumor|MPNST|Malignant Neoplasm of Peripheral Nerve Sheath|Malignant Neoplasm of the Peripheral Nerve Sheath|Malignant Neurilemmoma|Malignant Peripheral Nerve Sheath Neoplasm|Malignant Peripheral Nerve Sheath Tumour|Malignant Schwannoma|Malignant Tumor of Peripheral Nerve Sheath|Malignant Tumor of the Peripheral Nerve Sheath	An uncommon, highly aggressive malignant tumor, arising from the peripheral nerves and affecting mostly adults in their third to sixth decades of life.  It occurs usually in medium-sized and large nerves of the buttock, thigh, upper arm, or the paraspinal region.  It may be associated with neurofibromatosis 1 (NF1). -- 2004
C3799	Angiofibroma	Fibroma	Angiofibroma|Angiofibromatous Hyperplasia|Fibrous Papule|Telangiectatic Fibroma
C3800	Epithelioid_Hemangioendothelioma	Hemangioendothelioma|Malignant_Blood_Vessel_Neoplasm	Epithelioid Hemangioendothelioma|Epithelioid Angioendothelioma|Epithelioid Angiosarcoma
C3801	Hemangioblastoma	Neoplasm_of_Uncertain_Histogenesis	Capillary Hemangioblastoma|Angioblastoma|Hemangioblastoma	A histologically benign tumor, usually cystic with a vascular mural nodule, that is most often found in the cerebellum though it has been reported at other sites within the neuraxis. It is associated with von Hippel-Lindau disease (VHL gene located on chr 3p25-26).
C3802	Amelanotic_Melanoma	Melanoma	Amelanotic Melanoma|amelanotic melanoma	A type of skin cancer in which the cells do not make melanin. Skin lesions are often irregular and may be pink, red, or have light brown, tan, or gray at the edges.
C3803	Blue_Nevus	Benign_Melanocytic_Nevus	Blue Nevus|Blue Nevus of Skin|Blue Nevus of the Skin|Blue Skin Nevus
C3804	Intradermal_Nevus	Benign_Melanocytic_Nevus|Melanocytic_Skin_Neoplasm	Intradermal Nevus|Dermal Nevus
C3807	Calcifying_Odontogenic_Cyst	Cyst|Head_and_Neck_Finding	Calcifying Odontogenic Cyst
C3808	Rhabdoid_Tumor	Embryonal_Neoplasm|Malignant_Childhood_Neoplasm	Rhabdoid Tumor|Rhabdoid Sarcoma|rhabdoid tumor	A malignant tumor of either the central nervous system (CNS) or the kidney. Malignant rhabdoid tumors of the CNS often have an abnormality of chromosome 22. These tumors usually occur in children younger than 2 years.
C3809	Neuroendocrine_Neoplasm	Endocrine_Neoplasm	Neuroendocrine Neoplasm|Neuroendocrine Tumor|neuroendocrine tumor	A tumor derived from cells that release a hormone in response to a signal from the nervous system.  Some examples of neuroendocrine tumors are carcinoid tumors, islet cell tumors, medullary thyroid carcinoma, and pheochromocytoma.  These tumors secrete hormones in excess, causing a variety of symptoms.
C3810	Connective_and_Soft_Tissue_Neoplasm	Connective_and_Soft_Tissue_Disorder|Neoplasm_by_Site	Connective and Soft Tissue Neoplasm|Connective and Soft Tissue Tumor|Musculoskeletal and Soft Tissue Neoplasm|Musculoskeletal and Soft Tissue Tumor|Neoplasm of Skeletal and Soft Tissue|Neoplasm of Soft Tissue and Bone|Neoplasm of Soft Tissue and Skeleton|Skeletal and Soft Tissue Neoplasm|Skeletal and Soft Tissue Tumor|Soft Tissue and Bone Neoplasm|Soft Tissue and Bone Tumor|Tumor of Skeletal and Soft Tissue|Tumor of Soft Tissue and Bone|Tumor of Soft Tissue and Skeleton	A benign or malignant, primary or metastatic tumor affecting soft tissues or bone.  Representative examples include mesenchymal cell neoplasms, metastatic carcinomas to the bones, and primary neoplasms of uncertain histogenesis.
C3811	Malignant_Salivary_Gland_Neoplasm	Salivary_Gland_Neoplasm	Malignant Salivary Gland Neoplasm|Cancer of Salivary Gland|Cancer of the Salivary Gland|Malignant Neoplasm of Salivary Gland|Malignant Neoplasm of the Salivary Gland|Malignant Salivary Gland Tumor|Malignant Tumor of Salivary Gland|Malignant Tumor of the Salivary Gland|Salivary Gland Cancer
C3812	Carcinoma_of_Unknown_Primary	Infrequent_Neoplasm|Metastatic_Carcinoma|Metastatic_Neoplasm_of_Unknown_Primary_Origin	Carcinoma of Unknown Primary Origin|Carcinoma of Unknown Primary	A carcinoma which has metastasized from an unknown primary source
C3813	Metastatic_Neoplasm_to_the_Brain	Malignant_Brain_Neoplasm|Metastatic_Neoplasm_to_the_Central_Nervous_System	Metastatic Malignant Neoplasm to the Brain|Brain Metastases|Brain Metastasis|Metastatic Neoplasm to the Brain|Metastatic Tumor to the Brain|brain metastases	Cancer that has spread from the original (primary) tumor to the brain.
C3814	Metastasis_to_the_Leptomeninges	Malignant_Leptomeningeal_Neoplasm|Metastatic_Neoplasm_to_the_Central_Nervous_System	Metastatic Malignant Neoplasm to the Leptomeninges|Leptomeningeal Metastases|Leptomeningeal Metastasis|Metastasis to the Leptomeninges|Metastatic Neoplasm to the Leptomeninges|Metastatic Tumor to the Leptomeninges|leptomeningeal metastases|meningeal metastases|neoplastic meningitis	A condition in which cancer cells spread into the meninges (membranes that surround the brain and spinal cord).
C3815	Malignant_Ascites	Ascites	Malignant Ascites|ascites, malignant|malignant ascites	A condition in which fluid containing cancer cells collects in the abdomen.
C3816	Type_II_Achondrogenesis	Congenital_Abnormality	Type II Achondrogenesis|Achondrogenesis, Type II|Langer-Saldino Achondrogenesis
C3817	Cerebrooculofacioskeletal_Syndrome	Syndrome	Cerebrooculofacioskeletal Syndrome
C3818	Secondary_Amyloidosis	Amyloidosis	Secondary Amyloidosis
C3819	Primary_Amyloidosis	Amyloidosis|Monoclonal_Immunoglobulin_Deposition_Disease	Primary Amyloidosis	A plasma cell neoplasm that secretes an abnormal immunoglobulin, which deposits in various tissues and forms a beta-pleated sheet structure that binds Congo red dye with characteristic birefringence.  The sites of involvement include heart, liver, kidney, gut, tongue, nerves, and bone. (WHO, 2001) -- 2003
C3820	Cyclic_Neutropenia	Non-Neoplastic_Hematologic_Disorder	Cyclic Neutropenia|Cyclic Agranulocytosis|Cyclic Hematopoiesis|Dysplasia, Myelocytic Periodic|Periodic Neutropenia
C3821	Hemangiomatosis_with_Thrombocytopenia	Angiomatosis|Benign_Cutaneous_Vascular_Neoplasm	Hemangiomatosis with Thrombocytopenia|Hemangioma-Hemorrhage Syndrome|Kasabach-Merritt Syndrome|Thrombocytopenia-Hemangioma Syndrome|Thrombopenia-Hemangioma Syndrome
C3822	X-Linked_Agammaglobulinemia	Deficiency_of_Humoral_Immunity|Hereditary_Neoplastic_Syndrome	X-Linked Agammaglobulinemia|Bruton's Sex-Linked Agammaglobulinemia|Bruton's X-Linked Agammaglobulinemia	X-linked agammaglobulinemia.  An immunodeficiency state characterized (usually) by profoundly low concentrations of serum immunoglobulins of all classes, although occasionally significant amounts of one or more isotypes can be found.  The fundamental defect in XLA affects early lineage B cells.
C3823	Systolic_Hypertension	Hypertension	Systolic Hypertension
C3824	Lesion	Finding	Lesion|LES|lesion	(LEE-zhun) An area of abnormal tissue change.
C3825	Pseudolymphoma	Hematopoietic_and_Lymphoid_Neoplasms_Antiquated	Pseudolymphoma
C3826	Juvenile_Polyp	Gastrointestinal_Polyp	Juvenile Polyp|Retention Polyp
C3827	Nodular_Fasciitis	Benign_Fibrous_Soft_Tissue_Neoplasm	Nodular Fasciitis|Pseudosarcomatous Fasciitis
C3828	Combined_Hepatocellular_Carcinoma_and_Cholangiocarcinoma	Adenocarcinoma|Liver_and_Intrahepatic_Biliary_Tract_Carcinoma	Combined Hepatocellular Carcinoma and Cholangiocarcinoma|Carcinoma of Liver and Intrahepatic Biliary Tract|Carcinoma of the Liver and Intrahepatic Biliary Tract|Cholangiohepatoma|Hepatocholangiocarcinoma|Liver and Intrahepatic Biliary Tract Carcinoma|Mixed Hepatocellular Cholangiocarcinoma	A rare tumor containing unequivocal elements of both hepatocellular and cholangiocarcinoma that are intimately admixed.  This tumor should be distinguished from separate hepatocellular carcinoma and cholangiocarcinoma arising in the same liver.  The prognosis of this tumor is poor. --2002
C3829	Benign_Synovial_Neoplasm	Benign_Soft_Tissue_Neoplasm|Synovial_Neoplasm	Benign Synovial Neoplasm|Benign Neoplasm of Synovium|Benign Neoplasm of the Synovium|Benign Synovial Tumor|Benign Synovioma|Benign Tumor of Synovium|Benign Tumor of the Synovium
C3830	Chondromyxoid_Fibroma	Benign_Chondrogenic_Neoplasm|Fibroma	Chondromyxoid Fibroma
C3832	Malaise	Symptom	Malaise
C3833	Asymptomatic	Other_Finding	Asymptomatic|asymptomatic	Having no signs or symptoms of disease.
C3834	Ataxic_Gait	Motor_Manifestations	Ataxic Gait|ataxic gait	(ah-TAK-sik) Awkward, uncoordinated walking.
C3835	Reflux	Non-Neoplastic_Gastrointestinal_Disorder|Stomach_Disorder	Reflux|reflux	The term used when liquid backs up into the esophagus from the stomach.
C3836	Infertility	Sexual_Dysfunction_and_Infertility	Infertility|Fertility Disorders|Sterile|Sterility|infertility|sterile	The inability to produce children.
C3837	Neurological_Signs_and_Symptoms	Nervous_System_Finding|Symptom	Neurological Signs and Symptoms
C3838	Diastolic_Hypertension	Hypertension	Diastolic Hypertension
C3839	Pulmonary_Granuloma	Granuloma_by_Site	Pulmonary Granuloma|Lung Granuloma
C3840	Port_Wine_Type_Hemangioma	Vascular_Ectasia	Nevus Flammeus|Port Wine Birthmark|Port Wine Nevus|Port Wine Stain|Port Wine Stain of Skin|Port Wine Stain of the Skin|Port Wine Type Hemangioma|Salmon Patch Nevus
C3841	Congenital_Hemangioma	Hemangioma	Congenital Hemangioma|Congenital Angioma
C3842	Urothelial_Papilloma	Non-Invasive_Urothelial_Neoplasm|Papillary_Urothelial_Neoplasm|Transitional_Cell_Papilloma	Urothelial Papilloma	A rare benign condition, characterized by an exophytic papillary growth in the urinary tract with a central fibrovascular core.  The latter is lined by normal urothelium. -- 2003
C3843	Malignant_Ovarian_Cyst	Malignant_Ovarian_Neoplasm	Malignant Ovarian Cyst	Malignant cancerous cyst found in the ovary
C3844	Gallbladder_Carcinoma	Carcinoma|Infrequent_Neoplasm|Malignant_Gallbladder_Neoplasm	Gallbladder Carcinoma|Cancer of Gallbladder|Cancer of the Gallbladder|Carcinoma of Gallbladder|Carcinoma of the Gallbladder|Gallbladder Cancer	A malignant tumor arising from the epithelium of the gallbladder.  It is associated with the presence of gallstones.  Clinical symptoms are not specific and usually present late in the course.  Morphologically, most gallbladder carcinomas are adenocarcinomas; squamous cell carcinomas, adenosquamous carcinomas, signet ring carcinomas, and undifferentiated carcinomas can also occur. -- 2004
C3845	Neonatal_Leukemia	Childhood_Leukemia	Neonatal Leukemia	Leukemia in a newborn
C3846	Aggravated_Neurofibromatosis	Neurofibromatosis	Aggravated Neurofibromatosis|Neurofibromatosis Aggravated
C3847	Renal_Cell_Dysplasia	Dysplasia	Renal Cell Dysplasia|Cell Dysplasia Kidney
C3848	Benign_Female_Breast_Neoplasm	Benign_Breast_Neoplasm	Benign Female Breast Neoplasm|Benign Female Breast Tumor|Benign Neoplasm of Female Breast|Benign Neoplasm of the Female Breast|Benign Tumor of Female Breast|Benign Tumor of the Female Breast
C3850	Pancreatic_Carcinoma	Carcinoma|Common_Carcinoma|Malignant_Exocrine_Pancreas_Neoplasm	Pancreatic Carcinoma|Cancer of Pancreas|Cancer of the Pancreas|Carcinoma of Pancreas|Carcinoma of the Pancreas|Exocrine Pancreas Carcinoma|Pancreas Cancer|Pancreas Carcinoma|Pancreatic Cancer|pancreatic cancer	A carcinoma arising from the exocrine pancreas.  The overwhelming majority of pancreatic carcinomas are adenocarcinomas. --2002
C3851	Aggravated_Malignant_Neoplasm	Malignant_Neoplasm	Aggravated Malignant Neoplasm
C3852	Menopausal_Symptoms	Endocrine_System_Signs_and_Symptoms	Menopausal Symptom|Menopausal Symptoms
C3853	Mucositis	Non-Neoplastic_Gastrointestinal_Disorder	Mucositis|mucositis	A complication of some cancer therapies in which the lining of the digestive system becomes inflamed. Often seen as sores in the mouth.
C3854	Whole_Blood_Atypical_Lymphocyte_Counts	Retired_Concepts	Whole Blood Atypical Lymphocyte Counts
C3855	Simple_Ovarian_Cyst	Benign_Ovarian_Cyst	Simple Ovarian Cyst|Simple Cyst of Ovary|Simple Cyst of the Ovary
C3856	Ovarian_Dermoid_Cyst	Dermoid_Cyst|Ovarian_Cystic_Teratoma	Ovarian Dermoid Cyst|Dermoid Cyst of Ovary|Dermoid Cyst of the Ovary
C3857	Laboratory_Finding	Retired_Concepts	Laboratory Finding|Lab Findings	The result of a morphologic observation or a laboratory test performed on a tissue, body fluid, or peripheral blood sample.
C3858	Mental_and_Behavioral_Signs_and_Symptoms	Symptom	Mental and Behavioral Signs and Symptoms
C3859	Pediatric_AIDS	AIDS_Treatment_Research	Pediatric AIDS|AIDS in Pediatric Population|AIDS, Pediatric	AIDS related research with a minimum of 20% (or $100,000) research efforts related to children 0-18 years of age.  To include: Pregnant women, Neonates, Infants
C3860	Extrahepatic_Bile_Duct_Carcinoma	Bile_Duct_Carcinoma|Malignant_Extrahepatic_Bile_Duct_Neoplasm	Extrahepatic Bile Duct Carcinoma|Carcinoma of Extrahepatic Bile Duct|Carcinoma of the Extrahepatic Bile Duct|Extrahepatic Bile Duct Cancer	A carcinoma involving the extrahepatic bile ducts.  The majority are adenocarcinomas. -- 2003
C3861	Ependymal_Tumor_of_Brain	Ependymal_Tumor	Ependymal Tumor of Brain	A tumor arising from the ependymal lining of the ventricles.
C3862	Male_Breast_Carcinoma	Breast_Carcinoma	Male Breast Carcinoma|Carcinoma of Male Breast|Carcinoma of the Male Breast|Male Breast Cancer	A rare malignant tumor of the breast, affecting mostly older men.  It accounts for less than 1% of all malignancies in men.  The most common histologic type is invasive ductal carcinoma.  Most patients are treated with mastectomy. -- 2004
C3863	Intraductal_Breast_Papilloma	Intraductal_Papillary_Breast_Neoplasm|Intraductal_Papilloma	Intraductal Breast Papilloma|Breast Papilloma|Duct Papilloma of Breast|Duct Papilloma of the Breast|Ductal Breast Papilloma|Intraductal Papilloma of Breast|Intraductal Papilloma of the Breast|Papilloma of Breast|Papilloma of the Breast	A benign neoplasm arising from the ductal breast epithelium.  --2003
C3864	Colonic_Adenoma	Colon_Neoplasm|Colon_Polyp|Colorectal_Adenoma	Colon Adenoma|Adenoma of Colon|Adenoma of the Colon|Adenomatous Polyp of Colon|Adenomatous Polyp of the Colon|Colon Adenomatous Polyp|Colonic Adenoma|Colonic Adenomatous Polyp	Adenomatous colon polyps are considered to be precursor lesions of colon cancer.
C3865	Epididymal_Cyst	Cyst	Epididymal Cyst|Cyst of Epididymis|Cyst of the Epididymis
C3866	Esophageal_Leiomyoma	Benign_Esophageal_Neoplasm|Leiomyoma	Esophageal Leiomyoma|Esophagus Leiomyoma|Leiomyoma of Esophagus|Leiomyoma of the Esophagus	The most common mesenchymal tumor of the esophagus.  It occurs more frequently in males than females, and has a median age distribution between 30 and 35 years.  It involves the lower esophagus.  Dysphagia is the usual complaint.  Esophageal leiomyomas vary in size from a few millimeters up to 10cm in diameter.  The prognosis is good.  (WHO, 2000) -- 2003
C3867	Fallopian_Tube_Carcinoma	Carcinoma|Infrequent_Neoplasm|Malignant_Fallopian_Tube_Neoplasm	Fallopian Tube Carcinoma|Cancer of Fallopian Tube|Cancer of the Fallopian Tube|Carcinoma of Fallopian Tube|Carcinoma of the Fallopian Tube|Fallopian Tube Cancer	A carcinoma involving the fallopian tube which is attached to the uterine corpus (uterine body).  It may be a primary carcinoma, arising from the epithelium of the fallopian tube or, more commonly secondary from ovarian origin.  Most patients are postmenopausal, and postmenopausal bleeding is the most frequently seen symptom.  Morphologically, the majority of fallopian tube carcinomas are serous or endometrioid adenocarcinomas. -- 2004
C3868	Gastrointestinal_Stromal_Tumor	Neoplasm_of_Uncertain_Malignant_Potential|Stromal_Neoplasm	Gastrointestinal Stromal Tumor|GIST|Gastrointestinal Stromal Neoplasm|gastrointestinal stromal tumor	GIST. A type of tumor that usually begins in cells in the wall of the gastrointestinal tract.  It can be benign or malignant.
C3869	Hepatic_Hemangioma	Benign_Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Gastrointestinal_Hemangioma|Hepatic_Disorder|Intra-Abdominal_Hemangioma	Hepatic Hemangioma|Angioma of Liver|Angioma of the Liver|Hemangioma of Liver|Hemangioma of the Liver|Hepatic Angioma|Liver Angioma|Liver Hemangioma
C3870	Lymphangitic_Carcinomatosis	Carcinomatosis	Lymphangitic Carcinomatosis	Extensive infiltration of the lymphatic vessels by cancer cells, resulting in widespread cancer dissemination.  The lymphatic vessels appear as palpable, cord-like structures, especially in skin areas overlying the carcinoma.--2004
C3871	Nasopharyngeal_Carcinoma	Common_Carcinoma|Malignant_Nasopharyngeal_Neoplasm|Pharyngeal_Carcinoma	Nasopharyngeal Carcinoma|Cancer of Nasopharynx|Cancer of the Nasopharynx|Carcinoma of Nasopharynx|Carcinoma of the Nasopharynx|Nasopharyngeal Cancer
C3872	Brenner_Tumor_of_the_Ovary	Brenner_Tumor|Ovarian_Transitional_Cell_Neoplasm	Ovarian Brenner Tumor|Brenner Neoplasm of Ovary|Brenner Neoplasm of the Ovary|Brenner Tumor|Brenner Tumor of Ovary|Brenner Tumor of the Ovary|Ovarian Brenner Neoplasm	Brenner tumors constitute between 1% and 2% of all ovarian neoplasms.  The average age at presentation is about 50 years.  Grossly Brenner tumor is usually unilateral, firm and white or yellowish.  Microscopically it consists of solid and cystic nests of epithelial cells resembling transitional epithelium surrounded by an abundant stromal component of dense, fibroblastic nature. --2002
C3873	Ovarian_Germ_Cell_Tumor	Common_Germ_Cell_Neoplasm|Germ_Cell_Neoplasm|Ovarian_Neoplasm|Reproductive_Endocrine_Neoplasm	Ovarian Germ Cell Tumor|Germ Cell Neoplasm of Ovary|Germ Cell Neoplasm of the Ovary|Germ Cell Tumor of Ovary|Germ Cell Tumor of the Ovary|Ovarian Germ Cell Neoplasm	Benign and malignant germ cell tumors which arise in the ovaries.
C3874	Pancreatic_Cystadenocarcinoma	Cystadenocarcinoma|Pancreatic_Adenocarcinoma	Pancreatic Cystadenocarcinoma|Acinar Cell Cystadenocarcinoma|Cystadenocarcinoma of Pancreas|Cystadenocarcinoma of the Pancreas
C3875	Spinal_Cord_Ependymoma	Ependymoma|Spinal_Cord_Glial_Neoplasm	Spinal Cord Ependymoma|Ependymal Neoplasm of Spinal Cord|Ependymal Neoplasm of the Spinal Cord|Ependymal Tumor of Spinal Cord|Ependymal Tumor of the Spinal Cord|Ependymoma of Spinal Cord|Ependymoma of the Spinal Cord|Spinal Cord Ependymal Neoplasm|Spinal Cord Ependymal Tumor
C3876	Gastric_Leiomyoma	Benign_Gastric_Mesenchymal_Neoplasm|Leiomyoma	Gastric Leiomyoma|Leiomyoma of Stomach|Leiomyoma of the Stomach
C3877	Testicular_Teratoma	Pure_Testicular_Germ_Cell_Tumor|Teratoma|Testicular_Non-Seminomatous_Germ_Cell_Tumor	Testicular Teratoma|Teratoma of Testis|Teratoma of the Testis
C3878	Anaplastic_Thyroid_Carcinoma	Thyroid_Carcinoma|Undifferentiated_Carcinoma	Thyroid Gland Undifferentiated (Anaplastic) Carcinoma|Anaplastic Carcinoma of Thyroid|Anaplastic Carcinoma of Thyroid Gland|Anaplastic Carcinoma of the Thyroid|Anaplastic Carcinoma of the Thyroid Gland|Anaplastic Thyroid Cancer|Anaplastic Thyroid Carcinoma|Anaplastic Thyroid Gland Carcinoma|Dedifferentiated Thyroid Gland Carcinoma|Metaplastic Thyroid Gland Carcinoma|Pleomorphic Thyroid Gland Carcinoma|Sarcomatoid Thyroid Gland Carcinoma|Thyroid Gland Carcinosarcoma|Undifferentiated (Anaplastic) Thyroid Gland Carcinoma|Undifferentiated Carcinoma of Thyroid|Undifferentiated Carcinoma of Thyroid Gland|Undifferentiated Carcinoma of the Thyroid|Undifferentiated Carcinoma of the Thyroid Gland|Undifferentiated Thyroid Carcinoma|Undifferentiated Thyroid Gland Carcinoma|anaplastic thyroid cancer	(an-a-PLAS-tik) A rare, aggressive type of thyroid cancer in which the malignant (cancer) cells look very different from normal thyroid cells.
C3879	Medullary_Thyroid_Carcinoma	Medullary_Carcinoma|Neuroendocrine_Carcinoma|Thyroid_Carcinoma	Thyroid Gland Medullary Carcinoma|C Cell Carcinoma|Medullary Carcinoma of Thyroid|Medullary Carcinoma of Thyroid Gland|Medullary Carcinoma of the Thyroid|Medullary Carcinoma of the Thyroid Gland|Medullary Thyroid Cancer|Medullary Thyroid Carcinoma|Medullary Thyroid Gland Carcinoma|Parafollicular Cell Carcinoma|Thyroid Gland Neuroendocrine Carcinoma|Thyroid Medullary Carcinoma|medullary thyroid cancer	(MED-yoo-LAIR-ee) Cancer that develops in C cells of the thyroid. The C cells make a hormone (calcitonin) that helps maintain a healthy level of calcium in the blood.
C3880	Eyelid_Nevus	Eyelid_Neoplasm|Melanocytic_Nevus|Melanocytic_Skin_Neoplasm	Eyelid Nevus|Nevus of Eyelid|Nevus of the Eyelid
C3881	Leukoplakia_of_Gingiva	Oral_Cavity_Leukoplakia	Leukoplakia of Gingiva|Gingival Leukoplakia
C3882	Ovarian_Mass	Mass	Ovarian Mass|Mass of Ovary
C3883	Primary_Cerebral_Lymphoma	Retired_Concepts	Primary Cerebral Lymphoma|Primary Lymphoma of Cerebrum|Primary Lymphoma of the Cerebrum|Primary Lymphoma, Brain
C3884	Skin_Cyst	Cyst|Integumentary_System_Finding	Skin Cyst|Cutaneous Cyst|Cyst of Skin|Cyst of the Skin|Non-Neoplastic Skin Cyst
C3885	Testicular_Cyst	Cyst|Reproductive_System_Finding	Testicular Cyst|Cyst of Testis|Cyst of the Testis
C3886	Leukoplakia_of_Tongue	Oral_Cavity_Leukoplakia	Leukoplakia of Tongue
C3887	Vaginal_Cyst	Cyst|Reproductive_System_Finding	Vaginal Cyst|Cyst of Vagina|Cyst of the Vagina
C3888	Renal_Angiomyolipoma	Angiomyolipoma|Benign_Renal_Neoplasm	Renal Angiomyolipoma|Angiomyolipoma of Kidney|Angiomyolipoma of the Kidney
C3889	Pelvic_Inflammatory_Disease	Female_Non-Neoplastic_Reproductive_System_Disorder	Pelvic Inflammatory Disease	Pelvic inflammatory disease (PID) is an acute or chronic inflammation in the pelvic cavity.  It is most commonly caused by sexually transmitted diseases, including chlamydia and gonorrhea, that have ascended into the uterus, fallopian tubes, or ovaries as a result of intercourse or childbirth, or of surgical procedures, including insertion of IUDs or abortion.  PID may be either symptomatic or asymptomatic.  It may cause infertility and it may raise the risk of ectopic pregnancy.  PID is a disease associated with HIV infection.
C3890	Hypoxia	Other_Finding	Hypoxia	Having too little oxygen.
C3891	Color_Blindness	Vision_Disorder	Color Blindness
C3892	Mu_Heavy_Chain_Disease	Heavy_Chain_Disease	Mu Heavy Chain Disease	A clonal disorder characterized by the secretion of a mu heavy chain that lacks a variable region.  Most patients present with slowly progressive chronic lymphocytic leukemia (CLL).  In contrast to most cases of CLL, Mu heavy chain disease is associated with hepatosplenomegaly and absence of lymphadenopathy. --2004
C3894	Drug_Dependence	Dependence	Drug Dependence|Chemical Dependence	Drug dependence - replaced the term "drug addiction" and is defined as a state, psychic and sometimes also physical, resulting from the interaction between a living organism and a drug, characterized by behavioral and other responses that always include a compulsion to take the drug on a continuous or periodic basis in order to experience its psychic effects, and sometimes to avoid the discomfort of its absence. Tolerance may or may not be present. A person may be dependent on more than one drug.
C3895	Bare_Lymphocyte_Syndrome	Severe_Combined_Immunodeficiency	Bare Lymphocyte Syndrome
C3896	Minimal_Residual_Disease	Residual_Disease	Minimal Residual Disease|Detectable Residual Disease|MRD	remainder of a tumor or a neoplasm/cancer after primary, potentially curative therapy.
C3897	Isochromosome	Chromosomal_Aberration	Isochromosome
C3898	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue	Lymphoma_by_Site|Marginal_Zone_B-Cell_Lymphoma	Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue|Immunocytoma|MALT Lymphoma|MALT lymphoma|MALToma|Mucosa-Associated Lymphoid Tissue Lymphoma|mucosa-associated lymphoid tissue lymphoma	(MAK-ro-GLOB-u-li-NE-me-uh) A condition in which the blood contains high levels of large proteins and is too thick to flow through small blood vessels. One type is Waldenstrom's macroglobulinemia, which is a type of cancer.
C3899	Hantavirus_Infection	Viral_Infection	Hantavirus Infection
C3901	Compound_Nevus	Benign_Melanocytic_Nevus	Compound Nevus|Compound Nevus of Skin|Compound Nevus of the Skin|compound nevus	(KOM-pownd NEE-vus) A type of mole formed by groups of nevus cells found in the epidermis and dermis (the two main layers of tissue that make up the skin).
C3902	Telangiectatic_Osteosarcoma	Central_Osteosarcoma	Telangiectatic Osteosarcoma|Telangiectatic Osteogenic Sarcoma
C3903	Mixed_Glioma	Central_Nervous_System_Neoplasm|Neuroglial_Tumor	Mixed Glioma|Mixed Glial Neoplasm|Mixed Glial Tumor|Mixed Neuroglial Neoplasm|Mixed Neuroglial Tumor|mixed gliomas	A tumor composed of two or more glial cell types (astrocytes, ependymal cells, and oligodendrocytes). --2004
C3904	Papillary_Meningioma	Grade_III_Meningioma	Papillary Meningioma	A rare WHO grade III meningioma defined by the presence of a perivascular pseudopapillary pattern in at least part of the tumor. They are clinically aggressive. (Adapted from WHO 2000.) - 2004
C3905	Radiation_Enteritis	Enteritis|Radiation-Induced_Abnormalities	Radiation Enteritis	Inflammation of the small intestine caused by radiation exposure
C3906	Adrenal_Gland_Adenoma	Retired_Concepts	Adrenal Gland Adenoma|Adenoma of Adrenal Gland|Adenoma of the Adrenal Gland|Adrenal Adenoma|Benign Adenoma of Adrenal Gland|Benign Adenoma of the Adrenal Gland|Benign Adrenal Adenoma|Benign Adrenal Gland Adenoma	A benign neoplasm that can arise from any of the adrenal cortical layers.  It can be associated with the overproduction of glucocorticoids (Cushing's syndrome), androgenic or estrogenic steroids (adrenogenital syndrome), or mineralocorticoids (Conn's syndrome). (Diagnostic Surgical Pathology, 3rd ed.) -- 2003
C3907	Borderline_Hypertension	Hypertension	Borderline Hypertension
C3908	Ampulla_of_Vater_Carcinoma	Carcinoma|Malignant_Ampulla_of_Vater_Neoplasm	Ampulla of Vater Carcinoma|Ampulla of Vater Cancer|Ampullary Carcinoma
C3909	Gallbladder_Polyp	Gallbladder_Disorder|Gastrointestinal_Polyp	Gallbladder Polyp|Polyp of Gallbladder|Polyp of the Gallbladder
C3910	Molecular_Abnormality	root_node	Molecular Abnormality|Chromosomal, Gene, or Protein Abnormality|Cytogenetic or Molecular Genetic Abnormality|Genetic Abnormality
C3911	Stage_IA_Hodgkin_s_Lymphoma	Stage_I_Hodgkin_s_Lymphoma	Stage IA Hodgkin's Lymphoma|Hodgkin's Disease Stage IA|Hodgkin's Lymphoma Stage IA|Stage IA Hodgkin Lymphoma|Stage IA Hodgkin's Disease
C3912	Stage_IIA_Hodgkin_s_Lymphoma	Stage_II_Hodgkin_s_Lymphoma	Stage IIA Hodgkin's Lymphoma|Hodgkin's Disease Stage IIA|Hodgkin's Lymphoma Stage IIA|Stage IIA Hodgkin Lymphoma|Stage IIA Hodgkin's Disease
C3913	Stage_IIB_Hodgkin_s_Lymphoma	Stage_II_Hodgkin_s_Lymphoma	Stage IIB Hodgkin's Lymphoma|Hodgkin's Disease Stage IIB|Hodgkin's Lymphoma Stage IIB|Stage IIB Hodgkin Lymphoma|Stage IIB Hodgkin's Disease
C3914	Stage_IIIA_Hodgkin_s_Lymphoma	Stage_III_Hodgkin_s_Lymphoma	Stage IIIA Hodgkin's Lymphoma|Hodgkin's Disease Stage IIIA|Hodgkin's Lymphoma Stage IIIA|Stage IIIA Hodgkin Lymphoma|Stage IIIA Hodgkin's Disease
C3915	Small_Cell_Carcinoma	Common_Carcinoma|Neuroendocrine_Carcinoma	Small Cell Carcinoma|Oat Cell Cancer|Oat Cell Carcinoma|Poorly Differentiated Endocrine Neoplasm|Small Cell Cancer|oat cell cancer	A neuroendocrine carcinoma composed of small malignant cells which are often said to resemble "oat cells" under the microscope.  Small cell carcinoma most often affects the lungs.  Clinically, this is often a rapidly growing cancer that spreads to distant sites early.
C3916	Parathyroid_Adenoma	Adenoma|Benign_Endocrine_Neoplasm|Benign_Parathyroid_Neoplasm	Parathyroid Gland Adenoma|Adenoma of Parathyroid|Adenoma of Parathyroid Gland|Adenoma of the Parathyroid|Adenoma of the Parathyroid Gland|Parathyroid Adenoma	A benign tumor arising from the parenchymal cells of the parathyroid glands.  In the vast majority of cases, the tumor involves a single parathyroid gland.  It is associated with the symptoms of primary hyperparathyroidism, resulting from the excessive production of parathyroid hormone.  It is usually surrounded by a well-defined capsule.  Capsular invasion, vascular invasion, and perineural invasion are absent. (NCI05)
C3917	Vaginal_Carcinoma	Carcinoma|Malignant_Vaginal_Neoplasm	Vaginal Carcinoma|Cancer of Vagina|Cancer of the Vagina|Carcinoma of Vagina|Carcinoma of the Vagina|Vagina Cancer|Vagina Carcinoma|Vaginal Cancer	A carcinoma arising from the vaginal epithelium.  The majority of vaginal carcinomas are squamous cell carcinomas.  --2003
C3918	Extragonadal_Germ_Cell_Neoplasm	Germ_Cell_Neoplasm	Extragonadal Germ Cell Tumor|Extragonadal Germ Cell Neoplasm|Extragonadal Germ Cell Neoplasms|Neoplasm of Extragonadal Germ Cell|Neoplasm of the Extragonadal Germ Cell|Tumor of Extragonadal Germ Cell|Tumor of the Extragonadal Germ Cell
C3919	Suppurative_Granuloma	Granuloma	Suppurative Granuloma
C3920	Parapsoriasis_Lichenoides	Parapsoriasis	Parapsoriasis Lichenoides|Parapsoriasis Variegata|Poikiloderma Atrophicans Vasculare|Poikilodermic Parapsoriasis|Retiform Parapsoriasis	A rare condition that stimulated chronic radiodermatitis.  It is considered a variant of mycosis fungoides.  -- 2003
C3921	Small_Plaque_Parapsoriasis	Parapsoriasis_en_Plaques	Small Plaque Parapsoriasis
C3922	Large_Plaque_Parapsoriasis	Parapsoriasis	Large Plaque Parapsoriasis
C3923	Cutis_Marmorata	Telangiectasia	Cutis Marmorata|Telangiectatica Congenita
C3924	Becker_s_Nevus	Hamartoma|Non-Neoplastic_Nevus	Becker's Nevus|Linear Papular Ectodermal-Mesodermal Hamartoma|Melanosis Neviformis|Pigmented Hairy Epidermal Nevus|Pigmented Hairy Nevus of Becker|Progressive Cribriform and Zosteriform Hyperpigmentation
C3926	Angioma_Serpiginosum	Hemangioma_of_the_Skin	Angioma Serpiginosum
C3927	Angiokeratoma_of_Mibelli	Skin_Angiokeratoma	Angiokeratoma of Mibelli
C3928	Knuckle_Pads	Superficial_Fibromatosis	Knuckle Pads
C3929	Nasal_Sinus_Cyst	Cyst|Head_and_Neck_Finding	Nasal Sinus Cyst|Cyst of Nasal Sinus|Cyst of the Nasal Sinus|Paranasal Sinus Cyst
C3930	Paranasal_Sinus_Mucocele	Head_and_Neck_Finding	Paranasal Sinus Mucocele|Accessory Sinus Mucocele|Mucocele of Accessory Sinus|Mucocele of Nasal Sinus|Mucocele of Paranasal Sinus|Mucocele of the Accessory Sinus|Mucocele of the Nasal Sinus|Mucocele of the Paranasal Sinus|Nasal Sinus Mucocele
C3931	Maxillary_Sinus_Polyp	Benign_Maxillary_Sinus_Neoplasm|Paranasal_Sinus_Polyp	Maxillary Sinus Polyp|Maxillary Antral Polyp|Polyp of Maxillary Sinus|Polyp of the Maxillary Sinus
C3932	Ethmoid_Sinus_Polyp	Benign_Ethmoid_Sinus_Neoplasm|Paranasal_Sinus_Polyp	Ethmoid Sinus Polyp|Ethmoidal Polyp|Ethmoidal Sinus Polyp|Polyp of Ethmoid Sinus|Polyp of Ethmoidal Sinus|Polyp of the Ethmoid Sinus|Polyp of the Ethmoidal Sinus
C3933	Sphenoid_Sinus_Polyp	Benign_Sphenoid_Sinus_Neoplasm|Paranasal_Sinus_Polyp	Sphenoid Sinus Polyp|Polyp of Sphenoid Sinus|Polyp of Sphenoidal Sinus|Polyp of the Sphenoid Sinus|Polyp of the Sphenoidal Sinus|Sphenoidal Sinus Polyp
C3934	Pharyngeal_Cyst	Cyst|Head_and_Neck_Finding	Pharyngeal Cyst|Cyst of Pharynx|Cyst of the Pharynx|Pharynx Cyst
C3935	Leukoplakia_of_Vocal_Cords	Laryngeal_Keratosis	Leukoplakia of Vocal Cords|Keratotic Vocal Cord
C3936	Endocrine_Hypertension	Hypertension	Endocrine Hypertension
C3937	Non-Neoplastic_Nevus	Non-Neoplastic_Skin_Disorder	Non-Neoplastic Nevus
C3938	Turcot_Syndrome	Hereditary_Neoplastic_Syndrome	Turcot Syndrome	The syndrome of polyposis coli, colon cancer and brain tumors.
C3939	Bannayan_Syndrome	Hereditary_Neoplastic_Syndrome	Bannayan Syndrome|Bannayan-Riley-Ruvalcaba Syndrome|Bannayan-Zonana Syndrome|Macrocephaly with Multiple Lipomas and Hemangiomas
C3940	Hereditary_Benign_Intraepithelial_Dyskeratosis	Syndrome	Hereditary Benign Intraepithelial Dyskeratosis|Witkop-Von Sallmann Disease
C3942	Fibrous_Hamartoma_of_Infancy	Benign_Cutaneous_Fibrous_Neoplasm|Mesenchymal_Hamartoma	Fibrous Hamartoma of Infancy|Fibrous Hamartoma|Infantile Fibrous Hamartoma
C3943	Nevus_Anemicus	Vascular_Ectasia	Nevus Anemicus|Anemicus Nevus
C3944	Congenital_Melanocytic_Skin_Nevus	Congenital_Skin_Nevus	Congenital Melanocytic Skin Nevus|Congenital Melanocytic Nevus of Skin|Congenital Melanocytic Nevus of the Skin|Congenital Pigmented Nevus of Skin|Congenital Pigmented Nevus of the Skin|Congenital Pigmented Skin Nevus
C3945	Mongolian_Spot	Congenital_Melanocytic_Skin_Nevus	Mongolian Spot|Blue Sacral Spot|Mongolian Macula
C3946	Nevus_Comedonicus	Pilosebaceous_Hamartoma	Nevus Comedonicus|Acne Nevus|Acneiform Nevus|Comedo Nevus|Pilosebaceous Nevoid Disorder
C3947	Third_Ventricle_Colloid_Cyst	Intracranial_Colloid_Cyst	Third Ventricle Colloid Cyst|Colloid Cyst of Third Ventricle|Colloid Cyst of the Third Ventricle|Neuroepithelial Cyst of Third Ventricle|Neuroepithelial Cyst of the Third Ventricle|Paraphyseal Cyst of Third Ventricle|Paraphyseal Cyst of the Third Ventricle|Third Ventricle Neuroepithelial Cyst|Third Ventricle Paraphyseal Cyst	Colloid cysts i.e. cysts filled with gelatinous material, in the central nervous system often are found in the third ventricle. Due to their location, chronic or intermittent hydrocephalus can result. Case reports of sudden death due to acute obstructive hydrocephalus are in the literature. Colloid cysts are benign lesions that should be considered for neurosurgical resection.
C3948	Gingival_Polyp	Non-Neoplastic_Oral_Cavity_Disorder|Polyp	Gingival Polyp|Gum Polyp|Polyp of Gingiva|Polyp of Gum|Polyp of the Gingiva|Polyp of the Gum
C3949	Benign_Lymphoepithelial_Lesion_of_the_Salivary_Gland	Autoimmune_Disease|Salivary_Gland_Disorder	Benign Lymphoepithelial Lesion of the Salivary Gland|Benign Lymphoepithelial Lesion of Salivary Gland|Benign Salivary Gland Lymphoepithelial Lesion|Godwin Tumor
C3950	Oral_Mucosa_Lobular_Capillary_Hemangioma	Benign_Oral_Cavity_Neoplasm|Lobular_Capillary_Hemangioma	Oral Mucosa Lobular Capillary Hemangioma|Oral Mucosa Pyogenic Granuloma|Pyogenic Granuloma of Oral Mucosa|Pyogenic Granuloma of the Oral Mucosa
C3951	Leukoplakia_of_Lips	Oral_Leukoplakia	Leukoplakia of Lips
C3952	Hairy_Leukoplakia_of_Tongue	Leukoplakia_of_Tongue|Oral_Cavity_Hairy_Leukoplakia	Hairy Leukoplakia of Tongue
C3953	Esophageal_Leukoplakia	Leukoplakia	Esophageal Leukoplakia|Esophagus Leukoplakia|Leukoplakia of Esophagus|Leukoplakia of the Esophagus
C3954	Gastric_Polyp	Gastrointestinal_Polyp	Gastric Polyp|Gastric Polyposa|Gastric Polyposis|Polyps of Stomach|Polyps of the Stomach	A neoplastic or non-neoplastic lesion arising from the gastric mucosa.  -- 2003
C3955	Gastric_Intraepithelial_Neoplasia	Gastric_Neoplasm|Gastric_Precancerous_Condition|Gastrointestinal_Intraepithelial_Neoplasia|Glandular_Cell_Intraepithelial_Neoplasia	Gastric Intraepithelial Neoplasia|Dysplasia of Stomach|Dysplasia of the Stomach|Gastric Dysplasia|Gastric Glandular Intraepithelial Dysplasia|Gastric Glandular Intraepithelial Neoplasia|Gastric Intraepithelial Dysplasia	A intraepithelial neoplasia (dysplasia) that arises in either the native gastric mucosa or in metaplastic gastric epithelium.  It has a flat, polypoid or slightly depressed growth pattern.  It is graded as low grade (mild dysplasia) or high grade (moderate dysplasia and carcinoma in situ).  (WHO, 2000) -- 2003
C3956	Intestinal_Metaplasia_of_Gastric_Mucosa	Gastric_Precancerous_Condition	Intestinal Metaplasia of Gastric Mucosa
C3957	Anal_Polyp	Anal_Disorder|Gastrointestinal_Polyp	Anal Polyp|Polyp of Anus|Polyp of the Anus	This is a descriptive term referring of a mass of tissue that bulges or projects into the lumen of the anal lumen.  The mass is macroscopically visible and may either have a broad base attachment to the rectal wall, or be on a pedunculated stalk.  These may be benign or malignant.
C3958	Leiomyomatosis_Peritonealis_Disseminata	Benign_Peritoneal_Neoplasm|Leiomyomatosis	Leiomyomatosis Peritonealis Disseminata|Diffuse Peritoneal Leiomyomatosis
C3959	Liver_and_Biliary_Tract_Disorder	Gastrointestinal_Disorder	Liver and Biliary Tract Disorder|Liver and Biliary Tract Disease
C3960	Hepatic_Cyst	Cyst|Gastrointestinal_System_Finding	Hepatic Cyst|Cyst of Liver|Cyst of the Liver|Liver Cyst
C3961	Hyperuricemia	Abnormal_Blood_and_Hematology_Test_Result	Hyperuricemia|hyperuricemia	A buildup of uric acid (a byproduct of metabolism) in the blood; a side effect of some anticancer drugs.
C3962	Adenosine_Deaminase_Deficiency	Severe_Combined_Immunodeficiency	Adenosine Deaminase Deficiency	An autosomal recessive deficiency of the purine salvage enzyme adenosine deaminase which results in Severe Combined Immunodeficiency Disease (SCID).  The most common form of SCID, accounting for about 50% of autosomal recessive cases.  The first disease for which gene therapy was applied.
C3963	Purine-Nucleoside_Phosphorylase_Deficiency	Severe_Combined_Immunodeficiency	Purine-Nucleoside Phosphorylase Deficiency	PNP reversibly catalyzes the phosphorolysis of the purine nucleosides, (deoxy)inosine and (deoxy)guanosine, to their respective purine bases and the corresponding ribose-1-phosphate.  Deficiency in this enzyme is an autosomal recessive cause of combined immunodeficiency.
C3964	Thymine-Uraciluria	Genetic_Disorder|Metabolic_Disorder	Dihydrouracil Dehydrogenase Deficiency|Thymine-Uracilurea|Thymine-Uraciluria
C3965	Xeroderma_Pigmentosum_Complementation_Group_A	Xeroderma_Pigmentosum	Xeroderma Pigmentosum Complementation Group A|XP-A
C3966	Xeroderma_Pigmentosum_Complementation_Group_B	Xeroderma_Pigmentosum	Xeroderma Pigmentosum Complementation Group B|XP-B
C3967	Xeroderma_Pigmentosum_Complementation_Group_D	Xeroderma_Pigmentosum	Xeroderma Pigmentosum Complementation Group D|XP-D
C3968	Xeroderma_Pigmentosum_Complementation_Group_F	Xeroderma_Pigmentosum	Xeroderma Pigmentosum Complementation Group F|XP-F
C3969	Xeroderma_Pigmentosum_Complementation_Group_G	Xeroderma_Pigmentosum	Xeroderma Pigmentosum Complementation Group G|XP-G
C3970	Renal_Cyst	Cyst|Urinary_Tract_Finding	Renal Cyst|Cyst of Kidney|Cyst of the Kidney|Kidney Cyst	Abnormal fluid filled sac within the kidney, either acquired or congenital.
C3971	Urethral_Cyst	Cyst|Urinary_Tract_Finding	Urethral Cyst|Cyst of Urethra|Cyst of the Urethra|Urethra Cyst
C3972	Prostate_Fibroma	Benign_Prostate_Neoplasm|Fibroma	Prostate Fibroma|Fibroma of Prostate|Fibroma of the Prostate
C3973	Ovarian_Germinal_Inclusion_Cyst	Benign_Ovarian_Cyst	Ovarian Germinal Inclusion Cyst|Germinal Inclusion Cyst of Ovary|Germinal Inclusion Cyst of the Ovary
C3974	Squamous_Metaplasia_of_Cervix	Cervical_Metaplasia|Squamous_Metaplasia	Squamous Metaplasia of Cervix|Cervical Metaplasia Squamous
C3975	Cervical_Atypia	Atypia	Cervical Atypia|Cellular Cervical Abnormality|Cervical Atypism	Irregularity or alteration from normal cervical tissue. The spatial orientation of the cervical cells is often aberrant due to the lack of an organized growth process. 2005
C3976	Cervical_Leukoplakia	Genital_Leukoplakia	Cervical Leukoplakia|Cervix Leukoplakia|Cervix Uteri Leukoplakia|Leukoplakia of Cervix|Leukoplakia of Cervix Uteri|Leukoplakia of Uterine Cervix|Leukoplakia of the Cervix|Leukoplakia of the Cervix Uteri|Leukoplakia of the Uterine Cervix|Uterine Cervix Leukoplakia
C3977	Uterine_Cervix_Cyst	Cyst	Uterine Cervix Cyst|Cervical Cyst|Cervix Cyst|Cervix Uteri Cyst|Cyst of Cervix|Cyst of Cervix Uteri|Cyst of Uterine Cervix|Cyst of the Cervix|Cyst of the Cervix Uteri|Cyst of the Uterine Cervix
C3978	Vulvar_Polyp	Polyp|Vulvar_Non-Neoplastic_Disorder	Vulvar Polyp|Polyp of Vulva|Polyp of the Vulva|Vulva Polyp
C3979	Spinal_Meningeal_Cyst	Intraspinal_Cyst|Meningeal_Cyst	Spinal Meningeal Cyst|Cyst of Spinal Meninges|Cyst of the Spinal Meninges|Spinal Meninges Cyst
C3980	Visual_Epilepsy	Epilepsy	Visual Epilepsy
C3981	Paraneoplastic_Polyneuropathy	Paraneoplastic_Syndrome|Polyneuropathy	Paraneoplastic Polyneuropathy
C3982	Iris_Cyst	Cyst|Eye_and_Ear_Finding	Iris Cyst|Cyst of Iris|Cyst of the Iris
C3983	Iris_Idiopathic_Cyst	Iris_Cyst	Iris Idiopathic Cyst|Idiopathic Cyst of Iris|Idiopathic Cyst of the Iris
C3984	Iris_Exudative_Cyst	Iris_Cyst	Iris Exudative Cyst|Exudative Cyst of Iris|Exudative Cyst of the Iris
C3985	Ciliary_Body_Cyst	Cyst|Eye_and_Ear_Finding	Ciliary Body Cyst|Cyst of Ciliary Body|Cyst of the Ciliary Body
C3986	Ciliary_Body_Idiopathic_Cyst	Ciliary_Body_Cyst	Ciliary Body Idiopathic Cyst|Idiopathic Cyst of Ciliary Body|Idiopathic Cyst of the Ciliary Body
C3987	Eyelid_Sebaceous_Cyst	Eyelid_Cyst|Sebaceous_Cyst	Eyelid Sebaceous Cyst|Sebaceous Cyst of Eyelid|Sebaceous Cyst of the Eyelid
C3988	Inappropriate_Antidiuretic_Hormone_Secretion_Syndrome	Ectopic_Hormone_Secretion_Syndromes_Associated_with_Neoplasia	Syndrome of Inappropriate Antidiuretic Hormone Secretion|Ectopic ADH Secretion|Ectopic Antidiuretic Hormone Secretion|Inappropriate Antidiuretic Hormone Secretion Syndrome|SIADH	Abnormal secretion of antidiuretic hormone in conjunction with neoplastic growth occurring anywhere in the body.
C3989	Parathyroid_Hyperplasia	Hyperplasia	Parathyroid Hyperplasia|Hyperplasia of Parathyroid|Hyperplasia of the Parathyroid
C3990	Hyperimmunoglobulin_M_Syndrome	Hyperimmunoglobulin_Syndrome	Hyperimmunoglobulin M Syndrome	An immunodeficiency state characterized by very low serum IgG and IgA but either a normal or, more frequently, a markedly elevated concentration of polyclonal IgM.
C3991	Thrombocytopenia_Due_to_Immune_Destruction	Non-Neoplastic_Hematologic_Disorder	Thrombocytopenia Due to Immune Destruction
C3992	AIDS-Related_Kaposi_s_Sarcoma	AIDS-Related_Malignant_Neoplasm|Common_Connective_and_Soft_Tissue_Neoplasm|Kaposi_s_Sarcoma	AIDS-Related Kaposi's Sarcoma|AIDS Related Kaposi's Sarcoma|AIDS, Kaposi's Sarcoma|Autoimmune Deficiency Syndrome-Related Kaposi Sarcoma|Epidemic Kaposi's Sarcoma|Kaposi's Sarcoma AIDS Related|Kaposi's Sarcoma Epidemic Type	Also known as epidemic Kaposi's sarcoma, this is a malignant vascular tumor affecting individuals suffering from AIDS.  It can occur in the skin or internal organs. --2003
C3993	Stage_II_Colon_Cancer	Colon_Carcinoma|Stage_II_Colorectal_Cancer	Stage II Colon Cancer|AJCC Stage II Colon Cancer|Colon Cancer Stage II|Dukes B Carcinoma of Colon|Dukes B Carcinoma of the Colon|Dukes B Colon Carcinoma|Dukes B Colonic Carcinoma|Stage II Cancer of Colon|Stage II Cancer of the Colon|Stage II Carcinoma of Colon|Stage II Carcinoma of the Colon|Stage II Colon Carcinoma|Stage II Colonic Carcinoma	Stage II includes: IIA (T3, N0, M0); IIB (T4, N0, M0).  T3: Tumor invades through the muscularis propria or into non-peritonealized pericolic or perirectal tissues.  T4: Tumor directly invades other organs or structures, and/or perforates visceral peritoneum.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) - 2003
C3994	Stage_IV_Colon_Cancer	Colon_Carcinoma|Stage_IV_Colorectal_Cancer	Stage IV Colon Cancer|AJCC Stage IV Colon Cancer|Astler-Coller D Colon Carcinoma|Colon Cancer Stage IV|Colon Cancer, Stage IV|Dukes D Carcinoma of Colon|Dukes D Carcinoma of the Colon|Dukes D Colon Carcinoma|Dukes D Colonic Carcinoma|Stage IV Carcinoma of Colon|Stage IV Carcinoma of the Colon|Stage IV Colon Carcinoma|Stage IV Colonic Carcinoma	Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.) - 2003
C3995	Stage_IV_Breast_Cancer	Breast_Carcinoma	Stage IV Breast Cancer|Breast Cancer Metastatic|Breast Cancer Stage IV|Breast Carcinoma Stage IV|Metastatic Breast Cancer|Stage IV Breast Carcinoma|stage IV breast cancer	Cancer has spread to other organs of the body, most often the bones, lungs, liver, or brain; or tumor has spread locally to the skin and lymph nodes inside the neck, near the collarbone.
C3996	Monoclonal_Gammopathy_of_Undetermined_Significance	Plasma_Cell_Neoplasm	Monoclonal Gammopathy of Undetermined Significance|Benign Monoclonal Gammopathy|MGUS|Monoclonal Gammopathy of Unknown Significance	A plasma cell disorder in which an abnormal amount of a single immunoglobulin is present in the serum. Up to 25% of cases of monoclonal gammopathy of undetermined significance (MGUS) progress to a B-cell malignancy or myeloma. MGUS may occur in conjunction with various carcinomas, chronic inflammatory and infectious conditions, and other diseases. --2004
C3997	Childhood_Medulloblastoma	Childhood_Central_Nervous_System_Primitive_Neuroectodermal_Tumor|Medulloblastoma	Childhood Medulloblastoma|Pediatric Medulloblastoma	A glioma consisting of neoplastic cells that resemble the undifferentiated cells of the primitive medullary tube. The neoplastic cells are compactly arranged, round or ovoid, with hyperchromatic nuclei in relatively scant cytoplasm, and lie in small and poorly defined groups or, occasionally, in a pseudorosette pattern. (From Stedman, 25th ed) Medulloblastomas represent almost one third of all childhood nervous system neoplasms. (Kaye AH, Laws ER Brain Tumors. p. 561 Churchill)
C3998	Recurrent_Colon_Cancer	Colon_Carcinoma|Recurrent_Colorectal_Cancer	Recurrent Colon Cancer|Recurrent Cancer of Colon|Recurrent Cancer of the Colon|Recurrent Colon Carcinoma	Cancer of the colon reemerging after a period of remission.
C3999	Recurrent_Esophageal_Cancer	Esophageal_Carcinoma|Recurrent_Gastrointestinal_System_Cancer	Recurrent Esophageal Cancer|Esophageal Carcinoma, Recurrent|Oesophageal Carcinoma Recurrent|Recurrent Cancer of Esophagus|Recurrent Cancer of the Esophagus|Recurrent Carcinoma of Esophagus|Recurrent Carcinoma of the Esophagus|Recurrent Esophageal Carcinoma|Recurrent Esophagus Cancer|Relapsed Cancer of Esophagus|Relapsed Cancer of the Esophagus|Relapsed Carcinoma of Esophagus|Relapsed Carcinoma of the Esophagus|Relapsed Esophageal Cancer|Relapsed Esophagus Carcinoma	An esophageal cancer which has reappeared after a period of remission or after presumed treatment.
C4000	Stage_0_Cervical_Cancer	Carcinoma_in_situ|Cervical_Carcinoma|Grade_III_Intraepithelial_Neoplasia|High_Grade_Cervical_Intraepithelial_Neoplasia	Stage 0 Cervical Cancer|CIN 3|CIN Grade 3|Carcinoma in situ of Cervix|Carcinoma in situ of Cervix Uteri|Carcinoma in situ of Uterine Cervix|Carcinoma in situ of the Cervix|Carcinoma in situ of the Cervix Uteri|Carcinoma in situ of the Uterine Cervix|Cervical Carcinoma in situ|Cervical Intraepithelial Neoplasia Grade 3|Cervical Severe Dysplasia|Cervical cancer stage 0|Cervix Carcinoma in situ|Cervix Intraepithelial Neoplasia Grade 3|Cervix Severe Dysplasia|Cervix Uteri Carcinoma in situ|Cervix Uteri Intraepithelial Neoplasia Grade 3|Cervix Uteri Severe Dysplasia|FIGO Stage 0 Carcinoma of Cervix|FIGO Stage 0 Carcinoma of Cervix Uteri|FIGO Stage 0 Carcinoma of Uterine Cervix|FIGO Stage 0 Carcinoma of the Cervix|FIGO Stage 0 Carcinoma of the Cervix Uteri|FIGO Stage 0 Carcinoma of the Uterine Cervix|FIGO Stage 0 Cervical Carcinoma|FIGO Stage 0 Cervix Carcinoma|FIGO Stage 0 Cervix Uteri Carcinoma|FIGO Stage 0 Uterine Cervix Carcinoma|Grade 3 Cervical Intraepithelial Neoplasia|Intraepithelial Neoplasia of Cervix Grade 3|Intraepithelial Neoplasia of Cervix Uteri Grade 3|Intraepithelial Neoplasia of Uterine Cervix Grade 3|Intraepithelial Neoplasia of the Cervix Grade 3|Intraepithelial Neoplasia of the Cervix Uteri Grade 3|Intraepithelial Neoplasia of the Uterine Cervix Grade 3|Severe Cervical Dysplasia|Severe Dysplasia of Cervix|Severe Dysplasia of Cervix Uteri|Severe Dysplasia of Uterine Cervix|Severe Dysplasia of the Cervix|Severe Dysplasia of the Cervix Uteri|Severe Dysplasia of the Uterine Cervix|Uterine Cervix Carcinoma in situ|Uterine Cervix Intraepithelial Neoplasia Grade 3|Uterine Cervix Severe Dysplasia	Stage 0 includes: (Tis, N0, M0). Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C4001	Inflammatory_Breast_Carcinoma	Breast_Adenocarcinoma|Invasive_Breast_Carcinoma	Inflammatory Breast Carcinoma|Inflammatory Breast Cancer|Inflammatory Carcinoma of Breast|Inflammatory Carcinoma of the Breast|Mastitis Carcinomatosa|inflammatory breast cancer	A rare type of breast cancer in which breast cancer cells block the lymph vessels in the skin of the breast. The breast becomes red, swollen, and warm, and the skin of the breast may appear pitted or have ridges.
C4002	Extramedullary_Plasmacytoma	Plasmacytoma	Extraosseous Plasmacytoma|Extramedullary Plasmacytoma
C4003	Stage_IV_Renal_Cell_Cancer	Renal_Cell_Carcinoma	Stage IV Renal Cell Cancer|Renal Cell Cancer Stage IV|Renal Cell Carcinoma, Stage IV|Stage IV Renal Cell Carcinoma|stage IV kidney cancer	Kidney cancer that has spread beyond the kidney to lymph nodes or organs.
C4004	Gastric_Adenocarcinoma	Adenocarcinoma|Common_Carcinoma|Gastric_Carcinoma	Gastric Adenocarcinoma|Adenocarcinoma of Stomach|Adenocarcinoma of the Stomach|Stomach Adenocarcinoma	Gastric adenocarcinoma is an adenocarcinoma arising from the stomach glandular epithelium.  Gastric adenocarcinoma is primarily a disease of older individuals, most commonly develops after a long period of atrophic gastritis and is strongly associated with Helicobacter Pylori infection.  The lack of early symptoms often delays the diagnosis of gastric cancer.  The majority of patients present with advanced tumors which have poor rates of curability.  Microscopically, two important histologic types of gastric adenocarcinoma are recognized: the intestinal and diffuse type.  The overall prognosis of gastric adenocarcinomas is poor, even in patients who receive a "curative" resection (adapted from Sternberg's Surgical Pathology, 3rd ed., 1999). --2002
C4005	Malignant_Childhood_Neoplasm	Childhood_Neoplasm	Malignant Childhood Neoplasm|Childhood Cancer|Malignant Childhood Tumor|Malignant Pediatric Neoplasm|Malignant Pediatric Tumor|Pediatric Cancer	A malignant tumor that occurs in children.  Representative examples include soft tissue and bone sarcomas (e.g. osteosarcoma) and embryonal neoplasms (e.g. hepatoblastoma and rhabdoid tumor). -- 2004
C4006	Stage_IV_Endometrial_Cancer	Endometrial_Carcinoma	Stage IV Endometrial Cancer|Metastatic Endometrial Cancer|Metastatic Endometrial Carcinoma|Stage IV Cancer of Uterus|Stage IV Cancer of the Uterus|Stage IV Endometrial Carcinoma|stage IV cancer of the uterus|stage IV endometrial cancer	Cancer cells have spread to the lining of the bladder or rectum or to distant parts of the body.
C4007	Small_Intestinal_Lymphoma	Gastrointestinal_Lymphoma|Malignant_Small_Intestinal_Neoplasm	Small Intestinal Lymphoma|Lymphoma of Small Bowel|Lymphoma of Small Intestine|Lymphoma of the Small Bowel|Lymphoma of the Small Intestine|Primary Small Intestinal Lymphoma|Small Bowel Lymphoma|Small Intestine Lymphoma
C4008	Recurrent_Gallbladder_Carcinoma	Gallbladder_Carcinoma|Recurrent_Gastrointestinal_System_Cancer	Recurrent Gallbladder Cancer|Gallbladder Cancer, Recurrent|Recurrent Cancer of Gallbladder|Recurrent Cancer of the Gallbladder|Recurrent Gallbladder Carcinoma|Relapsed Cancer of Gallbladder|Relapsed Cancer of the Gallbladder|Relapsed Gallbladder Cancer	The reemergence of gall bladder cancer after a period of remission.
C4009	Non-Functioning_Pituitary_Gland_Neoplasm	Anterior_Pituitary_Gland_Neoplasm	Non-Functioning Pituitary Gland Neoplasm|Non-Functioning Neoplasm of Pituitary|Non-Functioning Neoplasm of Pituitary Gland|Non-Functioning Neoplasm of the Pituitary|Non-Functioning Neoplasm of the Pituitary Gland|Non-Functioning Pituitary Gland Tumor|Non-Functioning Pituitary Neoplasm|Non-Functioning Pituitary Tumor|Non-Functioning Tumor of Pituitary|Non-Functioning Tumor of Pituitary Gland|Non-Functioning Tumor of the Pituitary|Non-Functioning Tumor of the Pituitary Gland|Nonfunctioning Pituitary Tumor	A hormone producing or non-producing pituitary gland adenoma or carcinoma, not associated with a hormonal syndrome. (NCI05)
C4010	Adult_Craniopharyngioma	Adult_Intracranial_Neoplasm|Craniopharyngioma	Adult Craniopharyngioma|Adult Neoplasm of Rathke's Pouch|Adult Rathke Pouch Tumor|Adult Rathke's Pouch Neoplasm|Adult Rathke's Pouch Tumor|Adult Tumor of Rathke's Pouch	This is a pituitary tumor, which most frequently presents in children, but can occur throughout life.  It arises in cells derived from Rathke's pouch.  The tumor may interfere with pituitary function.  Findings may include endocrine disturbances and pressure symptoms.  Diagnostic procedure(s) include: MRI is the scan of choice.  Standard treatment options include: surgery alone if totally resectable or debulking surgery plus radiation therapy if unresectable. - 2003
C4011	Adult_Medulloblastoma	Adult_Central_Nervous_System_Primitive_Neuroectodermal_Tumor|Medulloblastoma	Adult Medulloblastoma
C4012	Stage_IV_Non-Small_Cell_Lung_Cancer	Non-Small_Cell_Lung_Carcinoma|Stage_IV_Lung_Cancer	Stage IV Non-Small Cell Lung Cancer|Metastatic Non-Oat Cell Carcinoma of Lung|Metastatic Non-Oat Cell Carcinoma of the Lung|Metastatic Non-Oat Cell Lung Carcinoma|Metastatic Non-Small Cell Carcinoma of Lung|Metastatic Non-Small Cell Carcinoma of the Lung|Metastatic Non-Small Cell Lung Carcinoma|Stage IV NSCLC|Stage IV Non-Oat Cell Carcinoma of Lung|Stage IV Non-Oat Cell Carcinoma of the Lung|Stage IV Non-Oat Cell Lung Carcinoma|Stage IV Non-Small Cell Carcinoma of Lung|Stage IV Non-Small Cell Carcinoma of the Lung|Stage IV Non-Small Cell Lung Carcinoma|stage IV non-small cell lung cancer	Cancer has spread to other parts of the body.
C4013	Malignant_Head_and_Neck_Neoplasm	Head_and_Neck_Neoplasm	Malignant Head and Neck Neoplasm|Cancer of Head and Neck|Cancer of the Head and Neck|Head and Neck Cancer|Malignant Head and Neck Tumor|Malignant Neoplasm of Head and Neck|Malignant Neoplasm of the Head and Neck|Malignant Tumor of Head and Neck|Malignant Tumor of the Head and Neck|head and neck cancer	Cancer that arises in the head or neck region (in the nasal cavity, sinuses, lip, mouth, salivary glands, throat, or larynx [voice box]).
C4014	Adult_Oligodendroglioma	Oligodendroglioma	Adult Oligodendroglioma|Grade II Adult Oligodendroglial Tumor
C4015	Metastatic_Neoplasm_to_the_Central_Nervous_System	Malignant_Central_Nervous_System_Neoplasm|Metastasis_to_the_Nervous_System	Metastatic Malignant Neoplasm to the Central Nervous System|CNS Metastases|CNS Metastasis|CNS metastases|Central Nervous System Metastases|Central Nervous System Metastasis|Metastatic Neoplasm to the CNS|Metastatic Neoplasm to the Central Nervous System|Metastatic Tumor to the CNS|Metastatic Tumor to the Central Nervous System	Cancer that has spread from the original (primary) tumor to the central nervous system.
C4016	Malignant_Bone_Neoplasm	Bone_Neoplasm	Malignant Bone Neoplasm|Bone Cancer|Cancer of Bone|Cancer of the Bone|Malignant Bone Tumor|Malignant Neoplasm of Bone|Malignant Neoplasm of the Bone|Malignant Osseous Neoplasm|Malignant Osseous Tumor|Malignant Tumor of Bone|Malignant Tumor of the Bone|Osseous Cancer	Bone cancer comprises two major malignancies: Primary bone cancer that started in the bones and secondary bone cancer that has spread to the bones from somewhere else in the body.  Primary bone cancers include osteosarcoma, chondrosarcoma, and Ewing's sarcoma.  Primary bone cancer is most common in children and adolescents.
C4017	Ductal_Breast_Carcinoma	Breast_Adenocarcinoma	Ductal Breast Carcinoma|Duct Adenocarcinoma|Duct Carcinoma|Ductal Adenocarcinoma|Ductal Carcinoma|Ductal Carcinoma of Breast|Ductal Carcinoma of the Breast|ductal carcinoma	A carcinoma arising from the ducts.  While ductal carcinomas can arise at other sites, this term is universally used to refer to carcinomas of the breast.  Ductal carcinomas account for about two thirds of all breast cancers.  Two types of ductal carcinomas have been described: Ductal carcinoma in situ (DCIS) and infiltrating ductal carcinoma.  The latter often spreads to the axillary lymph nodes.  The two forms of ductal carcinoma often coexist. --2002
C4018	Lobular_Carcinoma_in_situ_of_the_Breast	Lobular_Breast_Carcinoma|Lobular_Neoplasia|Stage_0_Breast_Cancer	Lobular Breast Carcinoma In Situ|LCIS|Lobular Ca in situ of Breast|Lobular Ca in situ of the Breast|Lobular Carcinoma In Situ of the Breast|Lobular Carcinoma in situ|Lobular Carcinoma in situ of Breast|Non-Infiltrating Lobular Breast Carcinoma|Non-Infiltrating Lobular Carcinoma|Non-Infiltrating Lobular Carcinoma of Breast|Non-Infiltrating Lobular Carcinoma of the Breast|Non-Invasive Lobular Breast Carcinoma|Non-Invasive Lobular Carcinoma of Breast|Non-Invasive Lobular Carcinoma of the Breast|lobular carcinoma in situ	(LOB-yoo-lar kar-sin-O-ma in SYE-too) LCIS. Abnormal cells found in the lobules of the breast. This condition seldom becomes invasive cancer; however, having lobular carcinoma in situ increases one's risk of developing breast cancer in either breast.
C4019	Paget_s_Disease_and_Intraductal_Carcinoma_of_the_Breast	Paget_s_Disease_of_the_Breast_without_Invasive_Carcinoma	Paget's Disease and Intraductal Carcinoma of the Breast|Paget's Disease and Intraductal Carcinoma of Breast|Paget's Disease of Breast with Intraductal Carcinoma|Paget's Disease of the Breast with Intraductal Carcinoma
C4020	Fibroblastic_Osteosarcoma	Central_Osteosarcoma	Fibroblastic Osteosarcoma|Fibroblastic Osteogenic Sarcoma|Fibrosarcomatous Osteogenic Sarcoma|Fibrosarcomatous Osteosarcoma
C4021	Chondrosarcomatous_Osteosarcoma	Osteosarcoma	Chondrosarcomatous Osteosarcoma|Chondroblastic Osteogenic Sarcoma|Chondroblastic Osteosarcoma|Chondrosarcomatous Osteogenic Sarcoma	An osteosarcoma characterised by the presence of atypical cartilage of variable cellularity.  It may or may not be associated with the presence of myxoid areas or focal bone formation. -- 2003
C4022	Acral_Lentiginous_Malignant_Melanoma	Cutaneous_Melanoma	Acral Lentiginous Melanoma|Acral Lentiginous Malignant Melanoma
C4023	Small_Cell_Osteosarcoma	Central_Osteosarcoma	Small Cell Osteosarcoma|Small Cell Osteogenic Sarcoma
C4024	Esophageal_Squamous_Cell_Carcinoma	Common_Carcinoma|Esophageal_Carcinoma|Squamous_Cell_Carcinoma	Esophageal Squamous Cell Carcinoma|Esophageal Epidermoid Carcinoma|Esophageal SCC|Esophagus SCC|Esophagus Squamous Cell Carcinoma|SCC of Esophagus|SCC of the Esophagus|Squamous Cell Carcinoma of Esophagus|Squamous Cell Carcinoma of the Esophagus	Squamous cell carcinomas of the esophagus typically arise after many years of tobacco and alcohol abuse and are exceedingly rare before the age of 30.  The median age is around 65 in both males and females.  Esophageal squamous cell carcinoma is located mostly in the middle and lower third of the esophagus.  Grossly, polypoid, ulcerated, plaque-like and occult lesions have been described.  The microscopic features are the same as in other squamous cell carcinomas.  Any degree of differentiation may occur, and variation within a single tumor is common.  The prognosis of esophageal squamous cell carcinomas is poor. --2002
C4025	Esophageal_Adenocarcinoma	Adenocarcinoma|Esophageal_Carcinoma	Esophageal Adenocarcinoma|Adenocarcinoma of Esophagus|Adenocarcinoma of the Esophagus|Esophagus Adenocarcinoma|Oesophageal Adenocarcinoma NOS	Esophageal adenocarcinoma is a malignant tumor with glandular differentiation arising predominantly from Barrett mucosa in the lower third of the esophagus.  Rare examples of esophageal adenocarcinoma deriving from ectopic gastric mucosa in the upper esophagus have also been reported.  Grossly, esophageal adenocarcinomas are similar to esophageal squamous cell carcinomas.  Microscopically, adenocarcinomas arising in the setting of Barrett esophagus are typically papillary and/or tubular.  The prognosis is poor.  --2002
C4026	Ovarian_Mucinous_Cystadenocarcinoma	Mucinous_Cystadenocarcinoma|Ovarian_Cystadenocarcinoma|Ovarian_Mucinous_Adenocarcinoma	Ovarian Mucinous Cystadenocarcinoma|Mucinous Cystadenocarcinoma of Ovary|Mucinous Cystadenocarcinoma of the Ovary
C4027	Vulvar_Paget_s_Disease	Extramammary_Paget_s_Disease|Vulvar_Adenocarcinoma	Paget's Disease of the Vulva|Paget's Disease of Vulva|Vulva Paget's Disease|Vulvar Paget's Disease
C4028	Cervical_Squamous_Cell_Carcinoma	Cervical_Carcinoma|Cervical_Squamous_Neoplasm|Common_Carcinoma|Squamous_Cell_Carcinoma	Cervical Squamous Cell Carcinoma|Cervix Squamous Cell Carcinoma|Cervix Uteri Squamous Cell Carcinoma|Squamous Cell Carcinoma of Cervix|Squamous Cell Carcinoma of Cervix Uteri|Squamous Cell Carcinoma of Uterine Cervix|Squamous Cell Carcinoma of the Cervix|Squamous Cell Carcinoma of the Cervix Uteri|Squamous Cell Carcinoma of the Uterine Cervix|Uterine Cervix Squamous Cell Carcinoma	Cervical squamous cell carcinoma usually evolves from a precancerous cervical lesion.  Increased numbers of sexual partners and human papilloma virus(HPV) infection are risk factors for cervical squamous cell carcinoma.  The following histologic patterns have been described: Conventional squamous cell carcinoma, papillary squamous cell carcinoma, transitional cell carcinoma, lymphoepithelioma-like carcinoma, verrucous carcinoma, condylomatous carcinoma and spindle cell carcinoma.  Survival is most closely related to the stage of disease at the time of diagnosis. --2002
C4029	Cervical_Adenocarcinoma	Adenocarcinoma|Cervical_Carcinoma|Cervical_Glandular_Neoplasm	Cervical Adenocarcinoma|Adenocarcinoma of Cervix|Adenocarcinoma of Cervix Uteri|Adenocarcinoma of Uterine Cervix|Adenocarcinoma of the Cervix|Adenocarcinoma of the Cervix Uteri|Adenocarcinoma of the Uterine Cervix|Cervix Adenocarcinoma|Cervix Uteri Adenocarcinoma|Uterine Cervix Adenocarcinoma	Cervical adenocarcinomas account for approximately 15% of invasive cervical carcinomas.  Increased numbers of sexual partners and human papilloma virus (HPV) infection are risk factors.  Grossly, advanced cervical adenocarcinoma may present as an exophytic mass, an ulcerated lesion, or diffuse cervical enlargement.  Microscopically, the majority of cervical adenocarcinomas are of the endocervical (mucinous) type. --2002
C4030	Urothelial_Transitional_Cell_Carcinoma	Malignant_Urinary_Tract_Neoplasm|Transitional_Cell_Carcinoma|Urothelial_Neoplasm	Urothelial Carcinoma|Transitional Cell Carcinoma of the Urinary Tract	A malignant neoplasm derived from the transitional epithelium of the urinary tract (urinary bladder, ureter, urethra, or renal pelvis).  It is frequently papillary. -- 2003
C4031	Bladder_Squamous_Cell_Carcinoma	Bladder_Carcinoma|Squamous_Cell_Carcinoma	Bladder Squamous Cell Carcinoma|Bladder Epidermoid Carcinoma|Epidermoid Carcinoma of Bladder|Epidermoid Carcinoma of Urinary Bladder|Epidermoid Carcinoma of the Bladder|Epidermoid Carcinoma of the Urinary Bladder|Squamous Cell Carcinoma of Bladder|Squamous Cell Carcinoma of Urinary Bladder|Squamous Cell Carcinoma of the Bladder|Squamous Cell Carcinoma of the Urinary Bladder|Urinary Bladder Epidermoid Carcinoma|Urinary Bladder Squamous Cell Carcinoma	Bladder squamous cell carcinomas arise from metaplastic bladder epithelium and represent less than 10% of bladder carcinomas.  The exception is the Middle East along the Nile Valley, where they represent the most common form of carcinomas because of the endemic nature of schistosomiasis.  Bladder squamous cell carcinomas are often associated with long-standing chronic inflammation of the bladder and have a poor prognosis.  The diagnosis of squamous cell carcinoma of the bladder should be reserved for those tumors that are predominantly keratin forming. --2002
C4032	Bladder_Adenocarcinoma	Adenocarcinoma|Bladder_Carcinoma	Bladder Adenocarcinoma|Adenocarcinoma of Bladder|Adenocarcinoma of Urinary Bladder|Adenocarcinoma of the Bladder|Adenocarcinoma of the Urinary Bladder|Urinary Bladder Adenocarcinoma	Primary bladder adenocarcinomas are rare, arise from metaplastic bladder epithelium and are frequently associated with long-standing local irritation.  The majority originate from the trigone and the posterior wall. --2002
C4033	Conventional_Clear_Cell_Renal_Cell_Carcinoma	Clear_Cell_Adenocarcinoma|Common_Carcinoma|Renal_Cell_Carcinoma	Conventional (Clear Cell) Renal Cell Carcinoma|Clear Cell Adenocarcinoma of Kidney|Clear Cell Adenocarcinoma of the Kidney|Clear Cell Adenocarcinoma, Kidney|Clear Cell Carcinoma of Kidney|Clear Cell Carcinoma of the Kidney|Conventional (Clear Cell) Renal Cell Adenocarcinoma|Conventional Renal Cell Carcinoma|Grawitz Tumor|Hypernephroma|Kidney Clear Cell Adenocarcinoma|Kidney Clear Cell Carcinoma|Renal Clear Cell Adenocarcinoma|Renal Clear Cell Carcinoma	A malignant epithelial neoplasm of the kidney characterized by the presence of lipid-containing clear cells within a vascular network.  The tumor may metastasize to unusual sites and late metastasis is common.
C4034	Recurrent_Laryngeal_Carcinoma	Laryngeal_Carcinoma|Recurrent_Head_and_Neck_Cancer	Recurrent Laryngeal Cancer|Recurrent Carcinoma of Larynx|Recurrent Carcinoma of the Larynx|Recurrent Laryngeal Carcinoma|Recurrent Larynx Cancer|Recurrent Larynx Carcinoma|Relapsed Carcinoma of Larynx|Relapsed Carcinoma of the Larynx|Relapsed Laryngeal Carcinoma|Relapsed Larynx Carcinoma	The reemergence of laryngeal cancer after a period of remission
C4035	Papillary_Thyroid_Carcinoma	Papillary_Adenocarcinoma|Well-differentiated_Thyroid_Carcinoma	Thyroid Gland Papillary Carcinoma|Papillary Cancer of Thyroid|Papillary Cancer of Thyroid Gland|Papillary Cancer of the Thyroid|Papillary Cancer of the Thyroid Gland|Papillary Carcinoma of Thyroid|Papillary Carcinoma of Thyroid Gland|Papillary Carcinoma of the Thyroid|Papillary Carcinoma of the Thyroid Gland|Papillary Thyroid Cancer|Papillary Thyroid Carcinoma|Papillary Thyroid Gland Carcinoma|Thyroid Papillary Carcinoma|papillary thyroid cancer	(PAP-i-lair-ee) Cancer that develops from cells in the thyroid and forms small finger-like projections.  The most common type of thyroid cancer, it grows slowly, is more common in women than in men, and often develops before age 40.
C4036	Refractory_Anemia_with_Ringed_Sideroblasts	Myelodysplastic_Syndrome	Refractory Anemia with Ringed Sideroblasts|Pure Sideroblastic Anemia|RARS	A myelodysplastic syndrome characterized by an anemia in which 15% or more of the erythroid precursors are ringed sideroblasts.  The ring sideroblast is an erythroid precursor in which one third or more of the nucleus is encircled by granules which are positive for iron stain.  It occurs primarily in older individuals.  The median survival exceeds 5 years.  (WHO, 2001) -- 2003
C4037	Acute_Myeloid_Leukemia_with_Multilineage_Dysplasia_following_Myelodysplastic_Syndrome	Acute_Myeloid_Leukemia_with_Multilineage_Dysplasia|Secondary_Acute_Myeloid_Leukemia	Acute Myeloid Leukemia with Multilineage Dysplasia following Myelodysplastic Syndrome|AML/MDS	A subtype of acute myeloid leukemia with multilineage dysplasia.  This subtype includes the vast majority of refractory anemia with excess blasts in transformation cases.  This latter term used to be part of the French-American-British classification scheme of myelodysplastic syndromes and has been eliminated from the WHO classification.  (WHO, 2001) -- 2003
C4038	Lung_Carcinoid_Tumor	Foregut_Carcinoid_Tumor|Lung_Neuroendocrine_Neoplasm	Lung Carcinoid Tumor|Carcinoid Neoplasm of Lung|Carcinoid Neoplasm of the Lung|Carcinoid Tumor of Lung|Carcinoid Tumor of the Lung|Lung Carcinoid Neoplasm|Pulmonary Carcinoid Neoplasm|Pulmonary Carcinoid Tumor
C4039	Adenocarcinoma_of_Unknown_Primary	Carcinoma_of_Unknown_Primary|Metastatic_Adenocarcinoma	Adenocarcinoma of Unknown Primary
C4040	Buccal_Mucosa_Squamous_Cell_Carcinoma	Malignant_Buccal_Mucosa_Neoplasm|Oral_Cavity_Squamous_Cell_Carcinoma	Buccal Mucosa Squamous Cell Carcinoma|SCC of Buccal Mucosa|SCC of the Buccal Mucosa|Squamous Cell Carcinoma of Buccal Mucosa|Squamous Cell Carcinoma of the Buccal Mucosa
C4041	Floor_of_Mouth_Squamous_Cell_Carcinoma	Floor_of_the_Mouth_Carcinoma|Oral_Cavity_Squamous_Cell_Carcinoma	Floor of Mouth Squamous Cell Carcinoma|Floor of Mouth SCC|SCC of Floor of Mouth|SCC of the Floor of Mouth|Squamous Cell Carcinoma of Floor of Mouth|Squamous Cell Carcinoma of the Floor of Mouth
C4042	Lip_Squamous_Cell_Carcinoma	Lip_Carcinoma|Lip_and_Oral_Cavity_Squamous_Cell_Carcinoma	Lip Squamous Cell Carcinoma|Lip SCC|SCC of Lip|SCC of the Lip|Squamous Cell Carcinoma of Lip|Squamous Cell Carcinoma of the Lip
C4043	Hypopharyngeal_Squamous_Cell_Carcinoma	Head_and_Neck_Squamous_Cell_Carcinoma|Hypopharyngeal_Carcinoma	Hypopharyngeal Squamous Cell Carcinoma|Epidermoid Carcinoma of Hypopharynx|Epidermoid Carcinoma of the Hypopharynx|Hypopharyngeal Epidermoid Carcinoma|Squamous Cell Carcinoma of Hypopharynx|Squamous Cell Carcinoma of the Hypopharynx
C4044	Laryngeal_Squamous_Cell_Carcinoma	Head_and_Neck_Squamous_Cell_Carcinoma|Laryngeal_Carcinoma	Laryngeal Squamous Cell Carcinoma|Epidermoid Carcinoma of Larynx|Epidermoid Carcinoma of the Larynx|Laryngeal Epidermoid Carcinoma|Larynx Epidermoid Carcinoma|Larynx Squamous Cell Carcinoma|Squamous Cell Carcinoma of Larynx|Squamous Cell Carcinoma of the Larynx	Squamous cell carcinoma is the most common type of laryngeal carcinoma.  The site of origin within the larynx influences the symptoms, histologic characteristics, and clinical behavior of squamous cell carcinoma.  The laryngeal squamous cell carcinomas can be glottic, supraglottic, and transglottic.  Glottic carcinoma is the most frequent form of laryngeal carcinoma in the United States.  Microscopically, squamous cell carcinomas of the larynx are similar in their appearance to squamous cell carcinomas arising elsewhere (adapted from Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999). --2002
C4045	Childhood_Oligodendroglioma	Childhood_Central_Nervous_System_Neoplasm|Oligodendroglioma	Childhood Oligodendroglioma|Pediatric Oligodendroglioma
C4046	AIDS-Related_Malignant_Neoplasm	Diseases_Associated_with_AIDS|Immunodeficiency-Related_Malignant_Neoplasm|Virus-Related_Malignant_Neoplasm	AIDS-Related Malignant Neoplasm|AIDS Related Cancer|AIDS-Related Cancer|AIDS-Related Malignancies|AIDS-Related Malignancy	Cancers that are found in HIV infected patients.  The most common AIDS-related cancers are Kaposi's sarcoma, and non-Hodgkin's lymphoma.  Other AIDS-related cancers include malignant neoplasms in lung and bronchus, oral, cervical, digestive systems and Hodgkin's disease.  (N J Med 2001 Jan;98(1):27-36)
C4047	Pilocytic_Astrocytoma	Astrocytic_Tumor	Pilocytic Astrocytoma|Grade I Astrocytic Neoplasm|Grade I Astrocytic Tumor|Grade I Astrocytoma	Pilocytic Astrocytoma, the most common glioma in children, is a WHO grade I astrocytic tumor. It is a generally well circumscribed, slowly growing, often cystic, astrocytoma. It is histologically characterized by a biphasic pattern with varying proportion of compacted bipolar cells which may have Rosenthal fibers (tapered corkscrew-shaped, brightly eosinophilic, intracytoplasmic hyaline masses) and loose textured multipolar cells with microcysts and granular bodies. (WHO)
C4048	Childhood_Pilocytic_Astrocytoma	Childhood_Astrocytic_Tumor|Pilocytic_Astrocytoma	Childhood Pilocytic Astrocytoma|Pediatric Pilocytic Astrocytoma|Pilocytic Astrocytoma of Childhood
C4049	Anaplastic_Ependymoma	Anaplastic_Malignant_Neoplasm|Ependymal_Tumor|Malignant_Glioma	Anaplastic Ependymoma|Anaplastic Ependymal Neoplasm|Anaplastic Ependymal Tumor|Malignant Ependymoma|Undifferentiated Ependymal Neoplasm|Undifferentiated Ependymal Tumor|Undifferentiated Ependymoma|WHO Grade III Ependymal Neoplasm|WHO Grade III Ependymal Tumor	Anaplastic Ependymoma (WHO grade III) is a malignant glioma of ependymal origin with accelerated growth and an unfavorable clinical outcome, particularly in children. Anaplastic Ependymomas show high mitotic activity, often accompanied by microvascular proliferation and pseudo-palisading necrosis. (Adapted from WHO.)
C4050	Mixed_Astrocytoma-Oligodendroglioma	Mixed_Glioma	Oligoastrocytoma|Mixed Astrocytic-Oligodendroglial Neoplasm|Mixed Astrocytic-Oligodendroglial Tumor|Mixed Astrocytoma-Oligodendroglioma|Mixed Oligo-Astrocytoma|WHO Grade II Mixed Glioma	Oligoastrocytoma is a tumor (WHO grade II) composed of a conspicuous mixture of two distinct neoplastic cell types morphologically resembling the tumor cells in Oligodendroglioma and Diffuse Astrocytoma (WHO grade II). (WHO)
C4051	Anaplastic_Malignant_Meningioma	Anaplastic_Malignant_Neoplasm|Grade_III_Meningioma|Malignant_Neoplasms_of_the_Meninges	Anaplastic (Malignant) Meningioma|Anaplastic Meningioma|Malignant Meningioma|Meningioma, Malignant|malignant meningioma	A WHO grade III meningioma exhibiting histological features of frank malignancy that exceed the abnormalities present in atypical meningioma. Anaplastic meningiomas are usually fatal, with median survival of less than 2 years. (Adapted from WHO 2000.) - 2004
C4052	Vulvar_Squamous_Cell_Carcinoma	Squamous_Cell_Carcinoma|Vulvar_Carcinoma|Vulvar_Squamous_Neoplasm	Vulvar Squamous Cell Carcinoma|Epidermoid Carcinoma of Vulva|Epidermoid Carcinoma of the Vulva|Epidermoid Cell Carcinoma of Vulva|Epidermoid Cell Carcinoma of the Vulva|Squamous Cell Carcinoma of Vulva|Squamous Cell Carcinoma of the Vulva|Vulva Epidermoid Carcinoma|Vulva Epidermoid Cell Carcinoma|Vulva Squamous Cell Carcinoma|Vulvar Epidermoid Carcinoma|Vulvar Epidermoid Cell Carcinoma
C4053	Drug_Extravasation	Side_Effect	Drug Extravasation	Leakage of drug from a vein into the surrounding tissue.
C4054	Anal_Condyloma_Acuminatum	Anal_Neoplasm|Condyloma_Acuminatum	Anal Condyloma Acuminatum|Condylomata of Anus|Condylomata of the Anus
C4055	Benign_Meningioma	Benign_Neoplasms_of_the_Meninges|Meningioma	Benign Meningioma|Meningioma, Benign	A benign growth that originates from the arachnoidal cap cells or the meningothelial cells, rarely invading brain parenchyma. The usual form of treatment is attempted gross total neurosurgical resection. These tumors tend to recur if incompletely excised (Kaye AH, Laws ER Brain Tumors Churchill Livingstone 1995)
C4056	Cervical_Metaplasia	Metaplasia	Cervical Metaplasia
C4057	Esophageal_Polyp	Esophageal_Disorder|Gastrointestinal_Polyp	Esophageal Polyp
C4058	Stage_IIIB_Hodgkin_s_Lymphoma	Stage_III_Hodgkin_s_Lymphoma	Stage IIIB Hodgkin's Lymphoma|Hodgkin's Disease Stage IIIB|Hodgkin's Lymphoma Stage IIIB|Stage IIIB Hodgkin Lymphoma|Stage IIIB Hodgkin's Disease
C4059	Stage_IVA_Hodgkin_s_Lymphoma	Stage_IV_Hodgkin_s_Lymphoma	Stage IVA Hodgkin's Lymphoma|Hodgkin's Disease Stage IVA|Hodgkin's Lymphoma Stage IVA|Stage IVA Hodgkin Lymphoma|Stage IVA Hodgkin's Disease
C4060	Ovarian_Cystadenoma	Benign_Ovarian_Epithelial_Neoplasm|Cystadenoma	Ovarian Cystadenoma|Benign Cystadenoma of Ovary|Benign Cystadenoma of the Ovary|Benign Ovarian Cystadenoma|Cystadenoma of Ovary|Cystadenoma of the Ovary|Cystoma Serosum Simplex|Simple Cystoma of Ovary|Simple Cystoma of the Ovary|Simple Ovarian Cystoma
C4061	Eyelid_Papilloma	Benign_Eyelid_Neoplasm|Papilloma	Eyelid Papilloma|Papilloma of Eyelid|Papilloma of the Eyelid
C4062	Leukostasis	Pathologic_Process	Leukostasis	A disorder involving the aberrant infiltration and aggregation of leukocytes into the vasculature of the body. Leukostasis is typically detected in the brain and lungs of persons with leukemia. It requires substantial ablative modalities to both reduce the number of cells present and to ensure dispersion of the aggregates.
C4063	Myomatous_Neoplasm	Mesenchymal_Cell_Neoplasm	Myomatous Neoplasm|Muscle Neoplasm|Muscle Tumor|Myomatous Tumor|Neoplasm of Muscle|Neoplasm of the Muscle|Tumor of Muscle|Tumor of the Muscle	A benign or malignant mesenchymal neoplasm arising from smooth or skeletal muscle. -- 2003
C4064	Prostatic_Intraepithelial_Neoplasia	Glandular_Cell_Intraepithelial_Neoplasia|Male_Reproductive_System_Precancerous_Condition|Prostate_Neoplasm	Prostatic Intraepithelial Neoplasia|PIN|PIN - Prostatic Intraepithelial Neoplasia|prostatic intraepithelial neoplasia	(pros-TAT-ik in-tra-eh-pih-THEEL-ee-ul NEE-o-play-zha) PIN.  Noncancerous growth of the cells lining the internal and external surfaces of the prostate gland.  It is an important sign that prostate cancer may develop.
C4065	Ectopic_Hormone_Secretion_Syndromes_Associated_with_Neoplasia	Endocrine_Syndrome	Ectopic Hormone Secretion Syndromes Associated with Neoplasia|Ectopic Hormone Secretion|Ectopic Hormone Secretion NOS|Neoplasm Associated Ectopic Hormone Secretion Syndromes	Abnormal secretion of hormones in conjunction with neoplastic growth occurring anywhere in the body.
C4068	Trabecular_Adenocarcinoma	Adenocarcinoma	Trabecular Adenocarcinoma|Trabecular Carcinoma
C4069	Ovarian_Endometriotic_Cyst	Ovarian_Cyst	Ovarian Endometriotic Cyst|Endometrioma of Ovary|Endometrioma of the Ovary|Endometriotic Cyst of Ovary|Endometriotic Cyst of the Ovary|Ovarian Endometrioma
C4070	Lentigo_Simplex	Lentigo	Lentigo Simplex
C4071	Xanthoma	Benign_Fibrohistiocytic_Neoplasm	Xanthoma	A benign fibrohistiocytic neoplasm characterized by a localized collection of histiocytes containing lipid.  Xanthomas usually occur in the skin and subcutaneous tissues, but occasionally they may involve the deep soft tissues.  -- 2003
C4072	Mesonephric_Adenocarcinoma	Adenocarcinoma|Mesonephric_Neoplasm	Mesonephric Adenocarcinoma|Malignant Mesonephroma
C4073	Meningeal_Sarcoma	Central_Nervous_System_Sarcoma|Malignant_Neoplasms_of_the_Meninges	Meningeal Sarcoma|Meninges Sarcoma|Sarcoma of Meninges|Sarcoma of the Meninges	A rare malignant tumor derived from meningeal connective tissue.  This neoplasm tends to grow rapidly and may metastasize outside the central nervous system. (From Donnet et al., J Neurooncol 1999 Mar;42(1):79-83)
C4074	Centroblastic_Lymphoma	Diffuse_Large_B-Cell_Lymphoma	Centroblastic Lymphoma|Diffuse Centroblastic Lymphoma	A B-cell non-Hodgkin's lymphoma composed of large noncleaved cells. This is a subtype of diffuse large B-cell non-Hodgkin's lymphoma. --2003
C4075	Morton_s_Neuroma	Traumatic_Neuroma	Morton's Neuroma|Interdigital Nerve Scar
C4076	Isosporiasis	Parasitic_Infection	Isosporiasis
C4077	Redness	Integumentary_System_Signs_and_Symptoms	Redness	Coloration of the skin; sign of inflammation
C4080	Perforation	Injury	Perforation	A hole or opening made through a membrane or other tissue or material.
C4081	Lipogranuloma	Granuloma	Lipogranuloma
C4082	Cholesterol_Granuloma	Granuloma	Cholesterol Granuloma
C4083	Hyperplastic_Polyp	Gastrointestinal_Polyp	Hyperplastic Polyp|Metaplastic Polyp	A polyp found mainly in the stomach and colon.  Microscopically, it is characterized by elongated, serrated crypts lined by proliferative epithelium.  Hyperplastic polyps are traditionally considered non-neoplastic, but ras mutation is common, clonality has been demonstrated and biochemical abnormalities and epidemiological associations that occur in colorectal adenomas and carcinomas have been found (WHO Tumors of the Digestive System, 2000).  However, a number of Gastrointestinal Pathologists reject the idea that hyperplastic polyps represent true neoplasms. --2002
C4085	Pale_Clear_Cell_Acanthoma	Retired_Concepts	Pale (Clear Cell) Acanthoma|Clear Cell Acanthoma of Degos|Degos' Acanthoma|Degos' Clear Cell Acanthoma
C4086	Dysplasia	Morphologic_Finding	Dysplasia|Dyscrasia|dyscrasia|dysplasia	(dis-PLAY-zha) Cells that look abnormal under a microscope but are not cancer.
C4087	Isolated_Follicular_Keratosis	Non-Neoplastic_Hair_Disorder	Isolated Follicular Keratosis|Warty Dyskeratoma
C4088	Epidermal_Nevus	Non-Neoplastic_Nevus	Epidermal Nevus
C4089	Polyposis	Neoplastic_Polyp	Polyposis|Multiple Polyps|polyposis	The development of numerous polyps (growths that protrude from a mucous membrane).
C4090	Malignant_Giant_Cell_Neoplasm	Giant_Cell_Neoplasm	Malignant Giant Cell Neoplasm|Malignant Giant Cell Tumor
C4092	Benign_Epithelial_Neoplasm	Epithelial_Neoplasm	Benign Epithelial Neoplasm|Benign Epithelial Tumor|Benign Neoplasm of Epithelium|Benign Neoplasm of the Epithelium|Benign Tumor of Epithelium|Benign Tumor of the Epithelium
C4093	Benign_Epithelioma	Epithelioma	Benign Epithelioma
C4094	Pleomorphic_Carcinoma	Sarcomatoid_Carcinoma	Pleomorphic Carcinoma
C4099	Small_Cell_Intermediate_Cell_Carcinoma	Grade_III_Neuroendocrine_Carcinoma	Small Cell Intermediate Cell Carcinoma|Small Cell Carcinoma, Intermediate Cell
C4101	Verrucous_Papilloma	Benign_Squamous_Cell_Neoplasm|Papilloma	Verrucous Papilloma
C4102	Papillary_Squamous_Cell_Carcinoma	Papillary_Carcinoma|Squamous_Cell_Carcinoma	Papillary Squamous Cell Carcinoma|Papillary Epidermoid Carcinoma|Papillary Epidermoid Cell Carcinoma|Papillary Squamous Carcinoma
C4104	Metastatic_Squamous_Cell_Carcinoma	Metastatic_Carcinoma|Squamous_Cell_Carcinoma	Metastatic Squamous Cell Carcinoma
C4105	Keratinizing_Squamous_Cell_Carcinoma	Squamous_Cell_Carcinoma	Keratinizing Squamous Cell Carcinoma	Squamous cell carcinomas with morphologically prominent production of keratin.
C4106	Pseudoglandular_Squamous_Cell_Carcinoma	Squamous_Cell_Carcinoma	Pseudoglandular Squamous Cell Carcinoma|Adenoid Squamous Carcinoma|Adenoid Squamous Cell Carcinoma|Pseudoglandular Epidermoid Carcinoma|Pseudoglandular Epidermoid Cell Carcinoma|Pseudoglandular Squamous Carcinoma
C4107	Nasopharyngeal_Type_Undifferentiated_Carcinoma	Undifferentiated_Carcinoma	Nasopharyngeal Type Undifferentiated Carcinoma|Lymphoepithelial Carcinoma|Lymphoepithelioma|Schminke Tumor|lymphoepithelioma	(LIM-fo-EP-ih-THEE-lee-O-ma) A type of cancer that begins in the tissues covering the nasopharynx (the upper part of the throat behind the nose).
C4108	Superficial_Multifocal_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma	Superficial Multifocal Basal Cell Carcinoma|Multicentric Basal Cell Carcinoma
C4109	Fibroepithelioma_of_Pinkus	Basal_Cell_Carcinoma	Fibroepithelioma of Pinkus|Fibroepithelial Basal Cell Carcinoma|Pinkus Tumor
C4110	Intraepidermal_Epithelioma_of_Jadassohn	Epithelioma	Intraepidermal Epithelioma of Jadassohn|Borst-Jadassohn Intraepidermal Carcinoma
C4111	Trichoepithelioma	Benign_Germinative_Epithelium_Neoplasm	Trichoepithelioma|Brooke's Tumor|Epithelioma Adenoides Cysticum	A benign tumor that can be difficult to differentiate from basal cell carcinoma
C4112	Trichofolliculoma	Benign_Germinative_Epithelium_Neoplasm	Trichofolliculoma
C4113	Trichilemmoma	Benign_Outer_Hair_Sheath_and_Infundibulum_Neoplasm	Trichilemmoma|Tricholemmoma
C4114	Pilomatrix_Carcinoma	Adnexal_Carcinoma|Malignant_Germinative_Follicular_Epithelium_Neoplasm	Pilomatrix Carcinoma|Invasive Pilomatrixoma|Matrical Carcinoma|Pilomatrix Carcinoma of Skin|Pilomatrix Carcinoma of the Skin|Pilomatrix Skin Carcinoma
C4115	Transitional_Cell_Papilloma	Papilloma|Transitional_Cell_Neoplasm	Transitional Cell Papilloma|Transitional Papilloma
C4116	Stage_0_Transitional_Cell_Carcinoma	Carcinoma_in_situ|Transitional_Cell_Carcinoma	Stage 0 Transitional Cell Carcinoma|Transitional Carcinoma in situ|Transitional Cell Carcinoma in situ|Urothelial Carcinoma in situ
C4117	Schneiderian_Papilloma	Transitional_Cell_Papilloma	Schneiderian Papilloma	Schneiderian papillomas are benign neoplasms that are associated with three key characteristics: tendency to recur, capacity for local destruction, and association with squamous cell carcinoma. They are classified into inverting, fungiform, and oncocytic varieties. The inverting and fungiform varieties are the most common, and the inverting variety has the highest rate of association with malignancy. (from J La State Med Soc 1997;149:310-5)
C4118	Inverted_Transitional_Cell_Papilloma	Inverted_Papilloma|Transitional_Cell_Papilloma	Inverted Transitional Cell Papilloma|Inverted Transitional Papilloma
C4119	Schneiderian_Carcinoma	Transitional_Cell_Carcinoma	Schneiderian Carcinoma
C4120	Sarcomatoid_Transitional_Cell_Carcinoma	Sarcomatoid_Carcinoma|Transitional_Cell_Carcinoma	Sarcomatoid Transitional Cell Carcinoma|Transitional Cell Spindle Cell Carcinoma|Transitional Spindle Cell Carcinoma
C4121	Basaloid_Carcinoma	Squamous_Cell_Carcinoma	Basaloid Carcinoma|Basaloid Squamous Cell Carcinoma
C4122	Papillary_Transitional_Cell_Carcinoma	Papillary_Carcinoma|Transitional_Cell_Carcinoma	Papillary Transitional Cell Carcinoma|Papillary Transitional Carcinoma
C4123	Adenocarcinoma_in_situ	Adenocarcinoma	Adenocarcinoma In Situ
C4124	Metastatic_Adenocarcinoma	Adenocarcinoma|Metastatic_Carcinoma	Metastatic Adenocarcinoma
C4125	Superficial_Spreading_Adenocarcinoma	Adenocarcinoma	Superficial Spreading Adenocarcinoma
C4126	Intestinal_Type_Adenocarcinoma	Adenocarcinoma	Intestinal Type Adenocarcinoma|Intestinal Type Carcinoma
C4127	Diffuse_Type_Adenocarcinoma	Adenocarcinoma	Diffuse Type Adenocarcinoma|Diffuse Type Carcinoma
C4129	Bile_Duct_Cystadenoma	Adenoma|Bile_Duct_Neoplasm|Cystadenoma	Bile Duct Cystadenoma|Cystadenoma of Bile Duct|Cystadenoma of the Bile Duct
C4130	Biliary_Cystadenocarcinoma	Cystadenocarcinoma|Extrahepatic_Bile_Duct_Adenocarcinoma	Bile Duct Cystadenocarcinoma|Biliary Cystadenocarcinoma|Cystadenocarcinoma of Bile Duct|Cystadenocarcinoma of the Bile Duct
C4131	Fibrolamellar_Hepatocellular_Carcinoma	Hepatocellular_Carcinoma	Fibrolamellar Hepatocellular Carcinoma|Fibrolamellar Carcinoma of Liver Cells|Fibrolamellar Carcinoma of the Liver Cells|Hepatocellular Fibrolamellar Carcinoma|Liver Cell Fibrolamellar Carcinoma|Oncocytic Hepatocellular Tumor|Polygonal Cell Type Hepatocellular Carcinoma with Fibrous Stroma	Fibrolamellar carcinoma is a distinctive morphologic variant of liver cell carcinoma seen predominantly in young patients without cirrhosis and associated with favorable prognosis.  The tumor cells are polygonal and deeply eosinophilic embedded in a fibrous stroma.  Over half of the fibrolamellar carcinomas are resectable, and the cure rate is about 50%. --2002
C4133	Tubular_Adenoma	Adenomatous_Polyp	Tubular Adenoma
C4134	Adenocarcinoma_in_Adenomatous_Polyposis_Coli	Adenocarcinoma_in_Adenomatous_Polyp	Adenocarcinoma in Adenomatous Polyposis Coli
C4135	Multiple_Adenomatous_Polyps	Adenomatous_Polyp	Multiple Adenomatous Polyps
C4136	Adenocarcinoma_in_Multiple_Adenomatous_Polyps	Adenocarcinoma_in_Adenomatous_Polyp	Adenocarcinoma in Multiple Adenomatous Polyps
C4137	Solid_Carcinoma	Carcinoma|Solid_Neoplasm	Solid Carcinoma
C4138	Appendix_Carcinoid_Tumor	Gastrointestinal_Carcinoid_Tumor|Malignant_Appendix_Neoplasm|Midgut_Carcinoid_Tumor	Appendix Carcinoid Tumor|Appendiceal Carcinoid Neoplasm|Appendiceal Carcinoid Tumor|Appendix Carcinoid Neoplasm|Carcinoid Neoplasm of Appendix|Carcinoid Neoplasm of the Appendix|Carcinoid Tumor of Appendix|Carcinoid Tumor of the Appendix	A rare tumor thought to arise from enterochromaffin cells.  It is a neuroendocrine tumor.  It is difficult to determine histologically whether the tumor in question is benign or malignant.  Though these tumors can occur almost anywhere in the body, the most common sites are, in order, the appendix, the small intestine, rectum and bronchus.  They can be detected at any age though the mean is 55 years with a median of 57 years.  If the carcinoid syndrome is not present, the presentation is related to the location.  Carcinoid syndrome, if present, is associated with diarrhea, cutaneous flushing, asthma, and valvular heart disease.
C4139	Combined_Carcinoid_and_Adenocarcinoma	Carcinoma	Combined Carcinoid and Adenocarcinoma|Adenocarcinoid Neoplasm|Adenocarcinoid Tumor|Combined Carcinoid Neoplasm and Adenocarcinoma|Combined Carcinoid Tumor and Adenocarcinoma|Composite Carcinoid|Composite Carcinoid Neoplasm|Composite Carcinoid Tumor|Mixed Carcinoid Neoplasm|Mixed Carcinoid Tumor
C4140	Alveolar_Adenoma	Lung_Adenoma	Alveolar Adenoma|Adenoma of Alveoli|Adenoma of the Alveoli
C4141	Adenocarcinoma_in_Villous_Adenoma	Adenocarcinoma_in_Adenomatous_Polyp	Adenocarcinoma in Villous Adenoma
C4142	Villous_Adenocarcinoma	Adenocarcinoma	Villous Adenocarcinoma
C4143	Tubulovillous_Adenoma	Adenomatous_Polyp	Tubulovillous Adenoma|tubulovillous adenoma	A type of polyp that grows in the colon and other places in the gastrointestinal tract and sometimes in other parts of the body. These adenomas may become malignant (cancerous).
C4144	Adenocarcinoma_in_situ_in_Tubulovillous_Adenoma	Adenocarcinoma_in_Tubulovillous_Adenoma|Adenocarcinoma_in_situ_in_Adenomatous_Polyp	Adenocarcinoma In Situ in Tubulovillous Adenoma
C4145	Adenocarcinoma_in_Tubulovillous_Adenoma	Adenocarcinoma_in_Adenomatous_Polyp	Adenocarcinoma in Tubulovillous Adenoma
C4146	Chromophobe_Renal_Cell_Carcinoma	Renal_Cell_Carcinoma	Chromophobe Renal Cell Carcinoma|Chromophobe Adenocarcinoma|Chromophobe Carcinoma|Chromophobe Carcinoma of Kidney|Chromophobe Carcinoma of the Kidney|Chromophobe Cell Carcinoma of Kidney|Chromophobe Cell Carcinoma of the Kidney|Renal Cell Carcinoma, Chromophobe Type	A type of carcinoma that comprises a minority of renal cell carcinomas.  It is characterized by loss of chromosomes 1 and Y.  Based on the cytoplasmic characteristics of the neoplastic cells, this type of carcinoma is classified as classic (typical) or eosinophilic.  It has a much better prognosis than other renal cell carcinomas.  -- 2003
C4147	Acidophil_Adenocarcinoma	Pituitary_Gland_Neoplasm_Antiquated	Pituitary Gland Acidophil Carcinoma|Acidophil Adenocarcinoma|Acidophil Carcinoma|Eosinophil Adenocarcinoma|Eosinophil Carcinoma
C4148	Mixed_Acidophil-Basophil_Adenoma	Pituitary_Gland_Neoplasm_Antiquated	Pituitary Gland Mixed Acidophil-Basophil Adenoma|Mixed Acidophil-Basophil Adenoma|Mixed Eosinophil-Basophil Adenoma
C4149	Mixed_Acidophil-Basophil_Carcinoma	Pituitary_Gland_Neoplasm_Antiquated	Pituitary Gland Mixed Acidophil-Basophil Carcinoma|Mixed Acidophil-Basophil Adenocarcinoma|Mixed Acidophil-Basophil Carcinoma|Mixed Eosinophil-Basophil Carcinoma
C4150	Basophilic_Adenocarcinoma	Adenocarcinoma	Basophilic Adenocarcinoma|Basophilic Carcinoma
C4151	Clear_Cell_Adenoma	Adenoma	Clear Cell Adenoma	A benign neoplasm composed of glands containing epithelial clear cells.
C4152	Lipid-Rich_Carcinoma	Carcinoma	Lipid-Rich Carcinoma
C4153	Glycogen-Rich_Carcinoma	Carcinoma	Glycogen-Rich Carcinoma
C4154	Parathyroid_Chief_Cell_Adenoma	Parathyroid_Adenoma	Parathyroid Gland Chief Cell Adenoma|Chief Cell Adenoma|Chief Cell Adenoma of Parathyroid|Chief Cell Adenoma of Parathyroid Gland|Chief Cell Adenoma of the Parathyroid|Chief Cell Adenoma of the Parathyroid Gland|Parathyroid Chief Cell Adenoma	A parathyroid gland adenoma composed predominantly of neoplastic chief cells.  These cells have either slightly eosinophilic or vacuolated cytoplasm, and round nuclei. (NCI05)
C4155	Water-Clear_Cell_Adenoma	Parathyroid_Clear_Cell_Adenoma	Parathyroid Gland Water-Clear Cell Adenoma|Water-Clear Cell Adenoma	A rare parathyroid gland adenoma composed of neoplastic cells with abundant cytoplasm.  The cytoplasm of the neoplastic cells is usually not entirely clear, and is often variably vacuolated, foamy, and granular.
C4156	Water-Clear_Cell_Adenocarcinoma	Neoplasm_by_Obsolete_Classification	Water-Clear Cell Adenocarcinoma
C4157	Mixed_Cell_Adenoma	Adenoma|Mixed_Neoplasm	Mixed Cell Adenoma
C4158	Mixed_Cell_Adenocarcinoma	Adenocarcinoma	Mixed Cell Adenocarcinoma
C4159	Lipoadenoma	Adenoma	Lipoadenoma
C4160	Microfollicular_Adenoma	Thyroid_Adenoma	Thyroid Gland Fetal Adenoma|Fetal Adenoma|Microfollicular Adenoma|Thyroid Gland Microfollicular Adenoma	A thyroid gland adenoma composed of microfollicular structures. (NCI05)
C4161	Macrofollicular_Adenoma	Thyroid_Adenoma	Thyroid Gland Macrofollicular Adenoma|Colloid Adenoma|Macrofollicular Adenoma	A thyroid gland adenoma composed of large size follicles. (NCI05)
C4162	Juxtaglomerular_Cell_Tumor	Benign_Renal_Neoplasm	Juxtaglomerular Cell Tumor|Juxtaglomerular Neoplasm|Juxtaglomerular Tumor|Reninoma
C4163	Compact_Cell_Adrenal_Cortical_Adenoma	Adrenal_Cortex_Adenoma	Adrenal Cortex Compact Cell Adenoma|Compact Cell Adrenal Cortex Adenoma|Compact Cell Adrenal Cortical Adenoma|Compact Cell Adrenocortical Adenoma	An adenoma of the adrenal cortex composed of neoplastic compact cells with eosinophilic cytoplasm.  (NCI05)
C4164	Heavily_Pigmented_Adrenal_Cortical_Adenoma	Adrenal_Cortex_Adenoma	Pigmented Adrenal Cortex Adenoma|Black Adenoma|Heavily Pigmented Adrenal Cortex Adenoma|Heavily Pigmented Adrenal Cortical Adenoma|Heavily Pigmented Adrenocortical Adenoma	A usually functioning adenoma of the adrenal cortex.  Grossly, it has a dark brown appearance and is characterized by the presence of neoplastic cells containing abundant intracytoplasmic lipofuscin.  It may be associated with Cushing's syndrome. (NCI05)
C4165	Clear_Cell_Adrenal_Cortical_Adenoma	Adrenal_Cortex_Adenoma|Clear_Cell_Adenoma	Adrenal Cortex Clear Cell Adenoma|Clear Cell Adrenal Cortex Adenoma|Clear Cell Adrenal Cortical Adenoma|Clear Cell Adrenocortical Adenoma	An adenoma of the adrenal cortex composed of neoplastic clear cells containing intracytoplasmic lipid droplets.  (NCI05)
C4166	Glomerulosa_Cell_Adrenal_Cortical_Adenoma	Adrenal_Cortex_Adenoma	Adrenal Cortex Glomerulosa Cell Adenoma|Glomerulosa Cell Adrenal Cortex Adenoma|Glomerulosa Cell Adrenal Cortical Adenoma|Glomerulosa Cell Adrenocortical Adenoma	An adenoma of the adrenal cortex composed of neoplastic cells with cytologic features of glomerulosa cells. (NCI05)
C4167	Mixed_Cell_Adrenal_Cortical_Adenoma	Adrenal_Cortex_Adenoma	Adrenal Cortex Mixed Cell Adenoma|Mixed Cell Adrenal Cortex Adenoma|Mixed Cell Adrenal Cortical Adenoma|Mixed Cell Adrenocortical Adenoma	An adenoma of the adrenal cortex composed of a mixed neoplastic cellular population, including varying numbers of neoplastic clear and compact cells . (NCI05)
C4168	Apocrine_Adenoma	Benign_Apocrine_Neoplasm|Sweat_Gland_Adenoma	Apocrine Adenoma
C4169	Apocrine_Carcinoma	Adenocarcinoma|Malignant_Apocrine_Neoplasm|Sweat_Gland_Carcinoma	Apocrine Gland Carcinoma|Apocrine Carcinoma|Carcinoma of Apocrine Gland
C4170	Eccrine_Spiradenoma	Eccrine_Neoplasm|Sweat_Gland_Adenoma	Eccrine Spiradenoma|Spiradenoma
C4171	Papillary_Hidradenoma_Hidradenoma_Papilliferum	Hidradenoma	Hidradenoma Papilliferum|Papillary Hidradenoma
C4172	Papillary_Syringadenoma_Syringocystadenoma_Papilliferum	Syringadenoma	Syringocystadenoma Papilliferum|Papillary Syringadenoma|Papillary Syringocystadenoma
C4173	Papillary_Eccrine_Adenoma	Benign_Eccrine_Neoplasm|Sweat_Gland_Adenoma	Papillary Eccrine Adenoma|Eccrine Papillary Adenoma
C4174	Sebaceous_Adenoma	Adenoma|Benign_Sebaceous_Neoplasm	Sebaceous Adenoma|Adenoma of Sebaceous Gland|Adenoma of the Sebaceous Gland|Sebaceous Gland Adenoma
C4175	Ceruminous_Adenoma	Apocrine_Adenoma|Ceruminous_Neoplasm	Ceruminous Adenoma|Ceruminoma
C4176	Ceruminous_Adenocarcinoma	Apocrine_Carcinoma|Ceruminous_Neoplasm	Ceruminous Adenocarcinoma
C4177	Borderline_Serous_Cystadenoma	Serous_Cystadenoma	Borderline Serous Cystadenoma|Borderline Malignancy Serous Cystadenoma|Low Malignancy Potential Serous Cystadenoma|Serous Tumor of Borderline Malignant Potential
C4178	Borderline_Papillary_Cystadenoma	Borderline_Cystadenoma|Papillary_Cystadenoma	Borderline Papillary Cystadenoma|Borderline Malignancy Papillary Cystadenoma|Low Malignancy Potential Papillary Cystadenoma
C4179	Papillary_Cystic_Neoplasm	Cystic_Neoplasm|Papillary_Epithelial_Neoplasm	Papillary Cystic Neoplasm|Papillary Cystic Tumor
C4180	Papillary_Serous_Cystadenoma	Papillary_Cystadenoma|Serous_Cystadenoma	Papillary Serous Cystadenoma
C4181	Serous_Surface_Papilloma	Papilloma	Serous Surface Papilloma
C4182	Serous_Surface_Papillary_Carcinoma	Papillary_Adenocarcinoma	Serous Surface Papillary Carcinoma
C4183	Borderline_Papillary_Serous_Cystadenoma	Borderline_Papillary_Cystadenoma	Borderline Papillary Serous Cystadenoma|Borderline Malignancy Papillary Serous Cystadenoma|Low Malignancy Potential Papillary Serous Cystadenoma|Low Malignant Potential Papillary Serous Neoplasm|Low Malignant Potential Papillary Serous Tumor|Papillary Serous Neoplasm of Low Malignant Potential|Papillary Serous Tumor of Low Malignant Potential
C4184	Papillary_Mucinous_Cystadenoma	Mucinous_Cystadenoma	Papillary Mucinous Cystadenoma|Papillary Pseudomucinous Cystadenoma
C4185	Borderline_Mucinous_Cystadenoma	Retired_Concepts	Borderline Mucinous Cystadenoma|Low Malignancy Potential Mucinous Cystadenoma	The existence and clinical significance of a borderline category in the mucinous tumors is not as well-defined as for their serous counterpart.  Hart and Norris proposed that a mucinous tumor should be classified as borderline when stromal invasion is uncertain and the atypical lining epithelium is less than four cells in thickness. --2002
C4186	Borderline_Papillary_Mucinous_Cystadenoma	Papillary_Mucinous_Cystadenoma	Borderline Papillary Mucinous Cystadenoma|Borderline Malignancy Papillary Mucinous Cystadenoma|Borderline Malignancy Papillary Pseudomucinous Cystadenoma|Borderline Papillary Pseudomucinous Cystadenoma|Low Malignancy Potential Papillary Mucinous Cystadenoma|Low Malignancy Potential Papillary Pseudomucinous Cystadenoma|Papillary Mucinous Neoplasm of Low Malignant Potential|Papillary Mucinous Tumor of Low Malignant Potential
C4188	Comedocarcinoma	Carcinoma	Comedocarcinoma|Comedo Carcinoma|comedo carcinoma	A type of ductal carcinoma in situ (very early-stage breast cancer).
C4189	Secretory_Breast_Carcinoma	Breast_Adenocarcinoma|Invasive_Breast_Carcinoma|Secretory_Carcinoma	Secretory Breast Carcinoma|Infiltrating Cystic Hypersecretory Duct Breast Carcinoma|Invasive Cystic Hypersecretory Duct Breast Carcinoma|Juvenile Breast Carcinoma|Juvenile Carcinoma of Breast|Juvenile Carcinoma of the Breast|Juvenile Secretory Breast Carcinoma|Juvenile Secretory Carcinoma of Breast|Juvenile Secretory Carcinoma of the Breast|Secretory Carcinoma of Breast|Secretory Carcinoma of the Breast
C4190	Intraductal_Papillary_Breast_Carcinoma	Intraductal_Papillary_Breast_Neoplasm|Papillary_Breast_Carcinoma	Intraductal Papillary Breast Carcinoma|Intraductal Papillary Adenocarcinoma|Intraductal Papillary Breast Adenocarcinoma|Intraductal Papillary Carcinoma|Non-Infiltrating Intraductal Papillary Adenocarcinoma|Non-Infiltrating Intraductal Papillary Carcinoma|Non-Infiltrating Papillary Breast Adenocarcinoma|Non-Infiltrating Papillary Breast Carcinoma|Non-Invasive Intraductal Papillary Adenocarcinoma|Non-Invasive Intraductal Papillary Carcinoma|Non-Invasive Papillary Breast Adenocarcinoma|Non-Invasive Papillary Breast Carcinoma
C4191	Intracystic_Papilloma	Papilloma	Intracystic Papilloma|Intracystic Papillary Adenoma
C4192	Nipple_Adenoma	Benign_Nipple_Neoplasm	Nipple Adenoma|Adenoma of Nipple|Adenoma of the Nipple
C4193	Medullary_Carcinoma_with_Amyloid_Stroma	Medullary_Thyroid_Carcinoma	Thyroid Gland Medullary Carcinoma with Amyloid Stroma|C Cell Adenocarcinoma with Amyloid Stroma|C Cell Carcinoma with Amyloid Stroma|Medullary Adenocarcinoma with Amyloid Stroma|Medullary Carcinoma with Amyloid Stroma|Medullary Thyroid Gland Carcinoma with Amyloid Stroma|Parafollicular Cell Adenocarcinoma with Amyloid Stroma|Parafollicular Cell Carcinoma with Amyloid Stroma	A medullary thyroid gland carcinoma characterized by the presence of amyloid stroma.  The majority of medullary carcinomas of the thyroid gland are associated with amyloid deposits.  The latter are highlighted with Congo red staining method. (NCI05)
C4194	Invasive_Ductal_Carcinoma_not_Otherwise_Specified	Ductal_Breast_Carcinoma|Invasive_Breast_Carcinoma	Invasive Ductal Carcinoma, Not Otherwise Specified|Infiltrating Ductal Adenocarcinoma|Infiltrating Ductal Breast Carcinoma|Infiltrating Ductal Carcinoma|Infiltrating Ductal Carcinoma of Breast|Infiltrating Ductal Carcinoma of the Breast|Invasive Ductal Adenocarcinoma|Invasive Ductal Breast Carcinoma|Invasive Ductal Carcinoma|Invasive Ductal Carcinoma of Breast|Invasive Ductal Carcinoma of the Breast|Invasive Ductal Carcinoma, NOS|Invasive Ductal Carcinoma, NST|Invasive Ductal Carcinoma, No Specific Type|infiltrating ductal carcinoma	Invasive ductal carcinoma is the most common type of invasive breast carcinoma (accounting for approximately 70% of breast carcinomas).  The gross appearance is usually typical with an irregular stellate outline.  Microscopically, randomly arranged epithelial elements are seen.  When large sheets of malignant cells are present, necrosis may be seen.  With adequate tissue sampling, in situ carcinoma can be demonstrated in association with the infiltrating carcinoma.  The in situ component is nearly always ductal but occasionally may be lobular or both. --2002
C4195	Ductal_Carcinoma_in_situ_and_Lobular_Carcinoma_in_situ	Intraductal_and_Lobular_Carcinoma|Stage_0_Breast_Cancer	Ductal Breast Carcinoma In Situ and Lobular Carcinoma In Situ|DCIS and LCIS of Breast|DCIS and LCIS of the Breast|Ductal Carcinoma in situ with Lobular Carcinoma in situ of Breast|Ductal Carcinoma in situ with Lobular Carcinoma in situ of the Breast|Ductal and Lobular Breast Carcinoma in situ|Ductal and Lobular Carcinoma in situ of Breast|Ductal and Lobular Carcinoma in situ of the Breast|Intraductal Carcinoma and Lobular Carcinoma in situ|Intraductal and Lobular Breast Carcinoma in situ|Intraductal and Lobular Carcinoma in situ of Breast|Intraductal and Lobular Carcinoma in situ of the Breast|Non-Infiltrating Ductal and Non-Infiltrating Lobular Breast Carcinoma|Non-Infiltrating Ductal with Non-Infiltrating Lobular Carcinoma of Breast|Non-Infiltrating Ductal with Non-Infiltrating Lobular Carcinoma of the Breast|Non-Invasive Ductal Breast Carcinoma with Non-Invasive Lobular Breast Carcinoma|Non-Invasive Ductal Carcinoma with Non-Invasive Lobular Carcinoma of Breast|Non-Invasive Ductal Carcinoma with Non-Invasive Lobular Carcinoma of the Breast|Non-Invasive Ductal and Non-Invasive Lobular Breast Carcinoma|Non-Invasive Ductal and Non-Invasive Lobular Carcinoma|Non-Invasive Ductal with Non-Invasive Lobular Breast Carcinoma
C4196	Acinar_Cell_Adenoma	Acinar_Cell_Neoplasm|Adenoma	Acinar Cell Adenoma|Acinar Adenoma|Acinic Cell Adenoma
C4197	Acinar_Cell_Neoplasm	Glandular_Cell_Neoplasm	Acinar Cell Neoplasm|Acinar Cell Tumor
C4198	Complex_Epithelial_Neoplasm	Epithelial_Neoplasm	Complex Epithelial Neoplasm|Complex Epithelial Tumor|Complex Neoplasm of Epithelium|Complex Neoplasm of the Epithelium|Complex Tumor of Epithelium|Complex Tumor of the Epithelium
C4199	Epithelial-Myoepithelial_Carcinoma	Clear_Cell_Adenocarcinoma|Infrequent_Neoplasm	Epithelial-Myoepithelial Carcinoma
C4200	Adenocarcinoma_with_Squamous_Metaplasia	Adenocarcinoma_with_Metaplasia|Complex_Epithelial_Neoplasm	Adenocarcinoma with Squamous Metaplasia|Adenoacanthoma
C4201	Adenocarcinoma_with_Spindle_Cell_Metaplasia	Adenocarcinoma_with_Metaplasia	Adenocarcinoma with Spindle Cell Metaplasia
C4202	Adenocarcinoma_with_Apocrine_Metaplasia	Adenocarcinoma_with_Metaplasia|Complex_Epithelial_Neoplasm	Adenocarcinoma with Apocrine Metaplasia
C4203	Luteinized_Thecoma	Thecoma	Ovarian Luteinized Thecoma|Luteinized Ovarian Thecoma|Luteinized Thecoma of Ovary|Luteinized Thecoma of the Ovary
C4204	Ovarian_Sclerosing_Stromal_Tumor	Benign_Ovarian_Sex_Cord-Stromal_Tumor|Thecoma-Fibroma_Group_Ovarian_Tumor	Ovarian Sclerosing Stromal Tumor|Ovarian Sclerosing Stromal Neoplasm|Sclerosing Stromal Neoplasm of Ovary|Sclerosing Stromal Neoplasm of the Ovary|Sclerosing Stromal Tumor of Ovary|Sclerosing Stromal Tumor of the Ovary
C4205	Malignant_Granulosa_Cell_Tumor	Granulosa_Cell_Tumor	Malignant Granulosa Cell Tumor|Malignant Granulosa Cell Neoplasm
C4206	Granulosa_Cell-Theca_Cell_Tumor	Retired_Concepts	Granulosa Cell-Theca Cell Tumor|Granulosa Cell-Theca Cell Neoplasm|Theca Cell-Granulosa Cell Neoplasm|Theca Cell-Granulosa Cell Tumor
C4207	Juvenile_Granulosa_Cell_Tumor	Granulosa_Cell_Tumor	Juvenile Type Granulosa Cell Tumor|Juvenile Type Granulosa Cell Neoplasm
C4208	Sex_Cord_Tumor_with_Annular_Tubules	Ovarian_Sex_Cord-Stromal_Tumor_of_Mixed_or_Unclassified_Cell_Types	Ovarian Sex Cord Tumor with Annular Tubules|Ovarian Sertoli Cell Tumor, Annular Tubular Variant|Ovarian Sex Cord Neoplasm with Annular Tubules
C4209	Benign_Androblastoma	Androblastoma	Well Differentiated Ovarian Sertoli-Leydig Cell Tumor|Benign Androblastoma|Benign Arrhenoblastoma|Benign Ovarian Sertoli-Leydig Cell Tumor
C4210	Malignant_Androblastoma	Androblastoma|Malignant_Ovarian_Sex_Cord-Stromal_Tumor	Poorly Differentiated Ovarian Sertoli-Leydig Cell Tumor|Malignant Androblastoma|Malignant Arrhenoblastoma|Malignant Ovarian Sertoli-Leydig Cell Tumor
C4211	Tubular_Androblastoma_with_Lipid_Storage	Tubular_Androblastoma-Sertoli_Cell_Tumor	Sertoli Cell Tumor with Lipid Storage|Sertoli Cell Neoplasm with Lipid Storage|Tubular Androblastoma with Lipid Storage
C4212	Benign_Leydig_Cell_Tumor	Leydig_Cell_Tumor	Benign Leydig Cell Tumor|Benign Interstitial Cell Neoplasm|Benign Interstitial Cell Tumor|Benign Leydig Cell Neoplasm
C4213	Malignant_Leydig_Cell_Tumor	Leydig_Cell_Tumor	Malignant Leydig Cell Tumor|Malignant Interstitial Cell Neoplasm|Malignant Interstitial Cell Tumor|Malignant Leydig Cell Neoplasm
C4214	Hilar_Cell_Tumor	Ovarian_Leydig_Cell_Tumor	Ovarian Hilar Cell Tumor|Hilar Cell Neoplasm|Hilar Cell Tumor of Ovary|Hilar Cell Tumor of the Ovary|Hilus Cell Neoplasm|Hilus Cell Tumor
C4215	Steroid_Cell_Tumor_of_the_Ovary	Ovarian_Sex_Cord-Stromal_Tumor	Ovarian Steroid Cell Tumor|Lipid Cell Neoplasm of Ovary|Lipid Cell Neoplasm of the Ovary|Lipid Cell Tumor of Ovary|Lipid Cell Tumor of the Ovary|Ovarian Lipid Cell Neoplasm|Ovarian Lipid Cell Tumor|Ovarian Lipoid Cell Neoplasm|Ovarian Steroid Cell Neoplasm|Steroid Cell Tumor of Ovary|Steroid Cell Tumor of the Ovary
C4216	Sympathetic_Paraganglioma	Paraganglionic_Neoplasm	Sympathetic Paraganglioma|Chromaffin Neoplasm|Chromaffin Tumor|Chromaffinoma|Sympathetic Paraganglionic Neoplasm	A benign or malignant paraganglioma arising from the chromaffin cells of the paraganglia that are located along the sympathetic nerves.  It includes extra-adrenal paragangliomas and paragangliomas that arise from the adrenal medulla.  The latter are commonly referred to as pheochromocytomas.  Representative examples of extra-adrenal sympathetic paragangliomas include the bladder, and superior and inferior paraaortic paragangliomas.  Clinical signs are related to the secretion of catecholamines resulting in hypertension.
C4217	Parasympathetic_Paraganglioma	Extra-Adrenal_Paraganglioma	Parasympathetic Paraganglioma|Parasympathetic Extra-Adrenal Paraganglioma|Parasympathetic Paraganglionic Neoplasm	A benign or malignant, usually non-functioning, extra-adrenal paraganglioma that arises from paraganglia located along the parasympathetic nerves.  Representative examples include aorticopulmonary, carotid body, jugulotympanic, and mediastinal paragangliomas.
C4218	Aortic_Body_Paraganglioma	Parasympathetic_Paraganglioma	Aorticopulmonary Paraganglioma|Aortic Body Neoplasm|Aortic Body Paraganglioma|Aortic Body Tumor|Neoplasm of Aortic Body|Neoplasm of the Aortic Body|Paraganglioma of Aortic Body|Paraganglioma of the Aortic Body|Tumor of Aortic Body|Tumor of the Aortic Body	A benign or malignant extra-adrenal parasympathetic paraganglioma that arises from paraganglia adjacent to the base of the heart and great vessels.
C4219	Malignant_Extra-Adrenal_Paraganglioma	Extra-Adrenal_Paraganglioma|Malignant_Paraganglionic_Neoplasm	Malignant Extra-Adrenal Paraganglioma	An extra-adrenal paraganglioma that metastasizes to regional or distant anatomic sites.  Common sites of metastasis include the lymph nodes, lungs, bones, and liver.
C4220	Malignant_Pheochromocytoma	Malignant_Adrenal_Medulla_Neoplasm|Malignant_Paraganglionic_Neoplasm|Pheochromocytoma	Malignant Adrenal Gland Pheochromocytoma|Malignant Adrenal Gland Chromaffin Neoplasm|Malignant Adrenal Gland Chromaffin Paraganglioma|Malignant Adrenal Gland Chromaffin Tumor|Malignant Adrenal Gland Chromaffinoma|Malignant Adrenal Gland Paraganglioma|Malignant Adrenal Medullary Paraganglioma|Malignant Adrenal Medullary Pheochromocytoma|Malignant Adrenal Pheochromocytoma|Malignant Pheochromocytoma|Pheochromoblastoma	A pheochromocytoma that metastasizes to other anatomic sites.  Common sites of metastasis include lymph nodes, bones, liver, and lung.  Morphologic features associated with malignant pheochromocytomas include: atypical mitotic figures, capsular and vascular invasion, tumor cell necrosis, and high mitotic activity.  (NCI05)
C4221	Malignant_Glomus_Tumor	Glomus_Tumor|Malignant_Perivascular_Neoplasm	Malignant Glomus Tumor|Glomangiosarcoma|Malignant Glomus Neoplasm
C4222	Glomangioma	Benign_Perivascular_Neoplasm|Hemangiopericytic_Neoplasm	Glomangioma
C4223	Glomangiomyoma	Benign_Perivascular_Neoplasm|Hemangiopericytic_Neoplasm	Glomangiomyoma
C4224	Melanoma_in_situ	Melanoma	Melanoma In Situ|Precancerous Melanosis
C4225	Nodular_Melanoma	Cutaneous_Melanoma	Nodular Melanoma|Nodular Malignant Melanoma|Nodular Malignant Melanoma of Skin|Nodular Malignant Melanoma of the Skin|Nodular Malignant Skin Melanoma
C4226	Balloon_Cell_Nevus	Benign_Melanocytic_Nevus	Balloon Cell Nevus
C4227	Balloon_Cell_Malignant_Skin_Melanoma	Cutaneous_Melanoma	Balloon Cell Skin Melanoma|Balloon Cell Malignant Melanoma|Balloon Cell Malignant Melanoma of Skin|Balloon Cell Malignant Melanoma of the Skin|Balloon Cell Malignant Skin Melanoma|Balloon Cell Melanoma
C4228	Regressing_Melanoma	Melanoma	Regressing Melanoma|Regressing Malignant Melanoma
C4229	Neuronevus	Benign_Melanocytic_Nevus	Neuronevus|Neural Nevus
C4230	Melanocytoma_of_the_Eyeball	Benign_Eye_Neoplasm|Melanocytoma	Melanocytoma of the Eyeball|Magnocellular Nevus|Melanocytoma of Eyeball
C4231	Junction_Nevus	Benign_Melanocytic_Nevus|Melanocytic_Skin_Neoplasm	Junctional Nevus|Intraepidermal Nevus|Intraepidermal Nevus of Skin|Intraepidermal Nevus of the Skin|Junction Nevus|Junctional Melanocytic Nevus|Junctional Melanocytoma|Junctional Nevus of Skin|Junctional Nevus of the Skin|Junctional Skin Nevus|junctional nevus	(JUNK-shun-ul NEE-vus) A mole found in the junction (border) between the epidermis and dermis layers of the skin. These moles may be pigmented and slightly raised, and have a higher risk of developing into malignant melanoma.
C4232	Melanoma_in_Junctional_Nevus	Cutaneous_Melanoma	Melanoma in Junctional Nevus|Malignant Melanoma in Junctional Nevus|Malignant Melanoma of Skin in Junctional Nevus|Malignant Melanoma of the Skin in Junctional Nevus|Malignant Skin Melanoma in Junctional Nevus
C4233	Precancerous_Melanosis	Cutaneous_Precancerous_Condition	Precancerous Melanosis
C4234	Giant_Pigmented_Nevus	Benign_Melanocytic_Nevus|Pigmented_Nevus	Giant Pigmented Nevus|Bathing Trunk Nevus|Giant Pigmented Nevus of Skin|Giant Pigmented Nevus of the Skin
C4235	Skin_Melanoma_in_Giant_Pigmented_Nevus	Cutaneous_Melanoma	Skin Melanoma in Giant Pigmented Nevus|Malignant Melanoma in Giant Pigmented Nevus|Malignant Melanoma of Skin in Giant Pigmented Nevus|Malignant Melanoma of the Skin in Giant Pigmented Nevus|Malignant Skin Melanoma in Giant Pigmented Nevus|Melanoma in Giant Pigmented Nevus
C4236	Epithelioid_Cell_Melanoma	Melanoma	Epithelioid Cell Melanoma|Epithelioid Cell Malignant Melanoma|Epithelioid Melanoma
C4237	Spindle_Cell_Melanoma	Malignant_Spindle_Cell_Neoplasm|Melanoma	Spindle Cell Melanoma|Malignant Spindle Cell Melanoma|Spindle Cell Malignant Melanoma
C4238	Type_A_Spindle_Cell_Melanoma	Spindle_Cell_Melanoma	Type A Spindle Cell Melanoma|Malignant Spindle Cell Type A Melanoma|Spindle Cell Type A Malignant Melanoma
C4239	Type_B_Spindle_Cell_Melanoma	Spindle_Cell_Melanoma	Type B Spindle Cell Melanoma|Malignant Spindle Cell Type B Melanoma|Spindle Cell Type B Malignant Melanoma
C4240	Blue_Nevus-Like_Melanoma	Cutaneous_Melanoma	Blue Nevus-Like Melanoma|Malignant Blue Nevus|Malignant Blue Nevus of Skin|Malignant Blue Nevus of the Skin|Malignant Cutaneous Blue Nevus|Malignant Skin Blue Nevus
C4241	Cellular_Blue_Nevus	Blue_Nevus	Cellular Blue Nevus|Cellular Blue Nevus of Skin|Cellular Blue Nevus of the Skin
C4242	Benign_Soft_Tissue_Neoplasm	Benign_Mesenchymal_Cell_Neoplasm|Soft_Tissue_Neoplasm	Benign Soft Tissue Neoplasm|Benign Neoplasm of Soft Tissue|Benign Neoplasm of the Soft Tissue|Benign Soft Tissue Tumor|Benign Tumor of Soft Tissue|Benign Tumor of the Soft Tissue	A benign tumor that arises from mesenchymal cells in extra skeletal sites.  The most common types are lipomas (from adipose or fatty tissues), hemangiomas (from vascular tissues), and benign fibrous histiocytoma (from fibrohistiocytic tissues). -- 2003
C4243	Sarcomatosis	Stage_IV_Soft_Tissue_Sarcoma	Sarcomatosis
C4244	Infantile_Fibrosarcoma	Childhood_Fibrosarcoma	Infantile Fibrosarcoma|Congenital Fibrosarcoma	A fibrosarcoma, occurring in infants and young children, sharing identical morphologic features with adult fibrosarcoma.  The prognosis is generally much more favorable than for adult fibrosarcoma, and it rarely metastasizes.  It usually affects the superficial and deep soft tissues of the extremities.  The majority of infantile fibrosarcomas carry the t(12;15)(p13;q26) translocation. -- 2004
C4245	Elastofibroma	Benign_Cutaneous_Fibrous_Neoplasm	Elastofibroma
C4246	Atypical_Fibroxanthoma	Intermediate_Cutaneous_Fibrohistiocytic_Neoplasm	Atypical Fibroxanthoma|Atypical Cutaneous Fibroxanthoma|Atypical Fibrous Histiocytoma|Atypical Fibroxanthoma of Skin|Atypical Fibroxanthoma of the Skin|Atypical Skin Fibroxanthoma|Superficial Malignant Fibrous Histiocytoma	An intermediate cutaneous fibrohistiocytic neoplasm, characterized by pleomorphic spindle cells, usually affecting the actinic-damaged skin of the elderly.  The tumor presents as a single cutaneous nodule which is often ulcerated.  Microscopically, it is indistinguishable from pleomorphic forms of malignant fibrous histiocytoma, and it is regarded by many experts as a superficial form of the latter.  The vast majority of patients have an excellent prognosis following conservative therapy.  Recurrences are infrequent, and metastasis is rare. -- 2003
C4247	Malignant_Fibrous_Histiocytoma	Histiocytoma|Sarcoma_of_the_Soft_Tissue_and_Bone	Malignant Fibrous Histiocytoma|Fibroxanthosarcoma|MFH|Malignant Fibrous Histiocytoma of Soft Tissue|Malignant Fibrous Histiocytoma of the Soft Tissue|Malignant Fibroxanthoma|malignant fibrous histiocytoma	A sarcoma characterized by the presence of fibroblasts and atypical, pleomorphic cells.  Cellular pleomorphism and a storiform pattern are the microscopic characteristics that define this malignant tumor.  Although it can occur in any part of the body, the lower extremity is the most common site of involvement.  This is generally an aggressive sarcoma, although certain morphologic variants (e.g., myxoid malignant fibrous histiocytoma) tend to have a more favorable prognosis. - 2003
C4248	Lipomatous_Neoplasm	Mesenchymal_Cell_Neoplasm	Lipomatous Neoplasm|Adipose Tissue Neoplasm|Adipose Tissue Tumor|Lipomatous Tumor|Neoplasm of Adipose Tissue|Neoplasm of the Adipose Tissue|Tumor of Adipose Tissue|Tumor of the Adipose Tissue	A benign or malignant tumor composed of adipose (fatty) tissue. -- 2003
C4249	Fibrolipoma	Benign_Lipomatous_Neoplasm	Fibrolipoma
C4250	Well-Differentiated_Liposarcoma	Liposarcoma|Sarcoma_Differentiation_Score_1|Sarcoma_NCI_Grade_1	Well Differentiated Liposarcoma|Atypical Lipomatous Tumor
C4251	Fibromyxolipoma	Benign_Lipomatous_Neoplasm	Fibromyxolipoma|Myxolipoma
C4252	Round_Cell_Liposarcoma	Myxoid_Round_Cell_Liposarcoma|Sarcoma_Differentiation_Score_3	Round Cell Liposarcoma|Cellular Myxoid Liposarcoma	An aggressive type of liposarcoma, composed of cells larger than the ones seen in the myxoid liposarcoma.  Usually, a high mitotic rate is present. -- 2003
C4253	Mixed_Liposarcoma	Liposarcoma	Mixed Liposarcoma
C4254	Spindle_Cell_Lipoma	Spindle_Cell_Pleomorphic_Lipoma	Spindle Cell Lipoma	A lipoma with prominent vascularity.  The vascular tissue is more abundant at the periphery of the tumor.  It occurs more frequently in younger individuals as a painful subcutaneous nodule, often on the arms. -- 2003
C4255	Lipoblastomatosis	Benign_Lipomatous_Neoplasm	Lipoblastomatosis|Fetal Lipomatosis	A benign disorder characterized by the presence of multiple lipoblastomas. -- 2003
C4256	Cellular_Leiomyoma	Leiomyoma	Cellular Leiomyoma
C4257	Bizarre_Leiomyoma	Leiomyoma	Atypical Leiomyoma|Bizarre Leiomyoma
C4258	Pleomorphic_Rhabdomyosarcoma	Embryonal_Rhabdomyosarcoma	Anaplastic Rhabdomyosarcoma|Pleomorphic Rhabdomyosarcoma
C4259	Mixed_Type_Rhabdomyosarcoma	Rhabdomyosarcoma	Mixed Type Rhabdomyosarcoma
C4260	Fetal_Rhabdomyoma	Rhabdomyoma	Fetal Rhabdomyoma
C4261	Adult_Rhabdomyoma	Rhabdomyoma	Adult Rhabdomyoma	A benign or malignant mesenchymal neoplasm arising from skeletal (striated) muscle. -- 2003
C4262	Endometrial_Stromal_Nodule	Benign_Uterine_Corpus_Neoplasm|Uterine_Corpus_Endometrial_Stromal_Neoplasm	Endometrial Stromal Nodule
C4263	Low_Grade_Endometrial_Stromal_Sarcoma	Endometrial_Stromal_Sarcoma	Low Grade Endometrial Stromal Sarcoma|Endolymphatic Stromal Myosis
C4264	Clear_Cell_Sarcoma_of_the_Kidney	Childhood_Renal_Neoplasm|Renal_Sarcoma	Clear Cell Sarcoma of the Kidney|CCSK|Childhood Clear Cell Sarcoma of the Kidney|Childhood Kidney Clear Cell Sarcoma|Childhood Renal Clear Cell Sarcoma|Clear Cell Sarcoma of Kidney|Kidney Clear Cell Sarcoma|Pediatric Kidney Clear Cell Sarcoma|Pediatric Renal Clear Cell Sarcoma|Renal Clear Cell Sarcoma|clear cell sarcoma of the kidney	A rare pediatric sarcoma affecting the kidney.  It is characterized by the presence of epithelioid or spindle cells forming cords or nests, separated by fibrovascular septa.  This type of sarcoma frequently metastasizes to the bones.
C4265	Pancreatoblastoma	Pancreatic_Carcinoma	Pancreatoblastoma
C4267	Benign_Mesenchymoma	Benign_Soft_Tissue_Neoplasm|Mesenchymoma	Benign Mesenchymoma
C4268	Malignant_Mesenchymoma	Malignant_Soft_Tissue_Neoplasm|Mesenchymoma	Malignant Mesenchymoma
C4270	Malignant_Brenner_Tumor	Brenner_Tumor_of_the_Ovary|Malignant_Ovarian_Transitional_Cell_Tumor	Malignant Ovarian Brenner Tumor|Malignant Brenner Tumor of Ovary|Malignant Brenner Tumor of the Ovary	Malignant Brenner tumor is a Brenner tumor characterised by a cytologically malignant cell population and stromal invasion. --2002
C4271	Intracanalicular_Fibroadenoma	Fibroadenoma	Intracanalicular Fibroadenoma|Intracanalicular Breast Fibroadenoma|Intracanalicular Fibroadenoma of Breast|Intracanalicular Fibroadenoma of the Breast
C4272	Pericanalicular_Fibroadenoma	Fibroadenoma	Pericanalicular Fibroadenoma|Pericanalicular Breast Fibroadenoma|Pericanalicular Fibroadenoma of Breast|Pericanalicular Fibroadenoma of the Breast
C4273	Giant_Fibroadenoma	Fibroadenoma	Giant Fibroadenoma|Giant Fibroadenoma of Breast|Giant Fibroadenoma of the Breast
C4274	Benign_Phyllodes_Tumor	Phyllodes_Tumor	Benign Phyllodes Tumor|Benign Cystosarcoma Phyllodes|Benign Phyllodes Neoplasm
C4275	Malignant_Phyllodes_Tumor	Phyllodes_Tumor	Malignant Phyllodes Tumor|Malignant Cystosarcoma Phyllodes|Malignant Phyllodes Neoplasm
C4276	Juvenile_Fibroadenoma	Fibroadenoma	Juvenile Fibroadenoma|Cellular Fibroadenoma|Juvenile Breast Fibroadenoma|Juvenile Fibroadenoma of Breast|Juvenile Fibroadenoma of the Breast
C4277	Synovial_Sarcoma_with_Spindle_Cell_Components	Synovial_Sarcoma	Synovial Sarcoma with Spindle Cell Components|Spindle Cell Synovial Sarcoma
C4278	Epithelioid_Synovial_Sarcoma	Synovial_Sarcoma	Epithelioid Synovial Sarcoma|Epithelial Sarcoma of Synovium|Epithelial Sarcoma of the Synovium|Epithelial Synovial Sarcoma|Epithelioid Cell Sarcoma of Synovium|Epithelioid Cell Sarcoma of the Synovium|Epithelioid Cell Synovial Sarcoma
C4279	Biphasic_Synovial_Sarcoma	Sarcoma_Differentiation_Score_3|Synovial_Sarcoma	Biphasic Synovial Sarcoma|Biphasic Sarcoma of Synovium|Biphasic Sarcoma of the Synovium
C4280	Benign_Mesothelioma	Retired_Concepts	Benign Mesothelioma|Benign Mesothelial Neoplasm|Benign Mesothelial Tumor|Benign Neoplasm of Mesothelium|Benign Neoplasm of the Mesothelium|Benign Tumor of Mesothelium|Benign Tumor of the Mesothelium|Mesothelioma, Benign
C4281	Localized_Benign_Fibrous_Mesothelioma	Benign_Pericardial_Neoplasm|Solitary_Fibrous_Tumor	Pericardial Solitary Fibrous Tumor|Benign Pericardial Mesothelial Neoplasm|Pericardial Benign Mesothelioma|Pericardial Fibroma|Pericardial Fibrous Mesothelioma|Pericardial Submesothelial Fibroma
C4282	Mixed_Mesothelioma	Diffuse_Malignant_Mesothelioma	Biphasic Mesothelioma|Malignant Biphasic Mesothelioma|Malignant Mixed Mesothelioma|Mixed Mesothelioma
C4284	Spermatocytic_Seminoma	Seminoma	Spermatocytic Seminoma
C4285	Polyembryoma	Retired_Concepts	Mixed Germ Cell Tumor|Polyembryoma
C4286	Immature_Teratoma	Teratoma	Immature Teratoma|Malignant Teratoma
C4287	Undifferentiated_Immature_Teratoma	Immature_Teratoma	Undifferentiated Immature Teratoma|Anaplastic Malignant Teratoma|Undifferentiated Malignant Teratoma
C4288	Intermediate_Immature_Teratoma	Immature_Teratoma	Intermediate Immature Teratoma|Intermediate Malignant Teratoma
C4289	Teratoma_with_Malignant_Transformation	Teratoma	Teratoma with Malignant Transformation|Dermoid Cyst with Malignant Transformation
C4290	Mixed_Germ_Cell_Neoplasm	Malignant_Germ_Cell_Neoplasm	Mixed Germ Cell Tumor|Combined Germ Cell Neoplasm|Combined Germ Cell Tumor|Mixed Germ Cell Neoplasm
C4291	Malignant_Struma_Ovarii	Struma_Ovarii	Malignant Struma Ovarii
C4292	Strumal_Carcinoid_Neoplasm	Ovarian_Carcinoid_Tumor	Strumal Carcinoid|Struma Ovarii and Carcinoid
C4293	Partial_Hydatidiform_Mole	Hydatidiform_Mole	Partial Hydatidiform Mole|Incomplete Hydatid Mole|Incomplete Hydatidiform Mole|Incomplete Molar Pregnancy|Partial Hydatid Mole|Partial Molar Pregnancy|Partial Mole
C4294	Benign_Mesonephroma	Mesonephroma	Benign Mesonephroma|Mesonephric Adenoma|Wolffian Duct Adenoma
C4295	Mesonephric_Neoplasm	Epithelial_Neoplasm|Infrequent_Neoplasm	Mesonephric Neoplasm|Mesonephric Tumor
C4296	Venous_Hemangioma	Hemangioma	Venous Hemangioma|Venous Angioma|Venous Malformation
C4297	Arteriovenous_Hemangioma	Hemangioma	Arteriovenous Hemangioma|Arteriovenous Angioma|Arteriovenous Malformation|Racemose Angioma|Racemose Hemangioma
C4298	Epithelioid_Hemangioma	Hemangioma	Epithelioid Hemangioma|Angiolymphoid Hyperplasia with Eosinophilia|Histiocytoid Hemangioma
C4299	Verrucous_Keratotic_Hemangioma	Capillary_Hemangioma|Hemangioma_of_the_Skin	Verrucous Hemangioma|Verrucous Keratotic Hemangioma
C4300	Benign_Hemangiopericytoma	Benign_Perivascular_Neoplasm|Hemangiopericytoma	Benign Hemangiopericytoma
C4301	Malignant_Hemangiopericytoma	Hemangiopericytoma|Malignant_Perivascular_Neoplasm	Malignant Hemangiopericytoma|Malignant Hemangiopericytoma NOS	An uncommon malignant neoplasm arising from pericytes.  Distinction between benign and malignant hemangiopericytoma may be difficult or even impossible on morphologic grounds alone. -- 2003
C4302	Periosteal_Chondroma	Enchondroma	Periosteal Chondroma|Juxtacortical Chondroma
C4303	Myxoid_Chondrosarcoma	Chondrosarcoma|Sarcoma_Differentiation_Score_2	Myxoid Chondrosarcoma
C4304	Malignant_Giant_Cell_Tumor_of_Bone	Giant_Cell_Tumor_of_Bone|Malignant_Bone_Neoplasm|Malignant_Giant_Cell_Neoplasm	Malignant Giant Cell Tumor of Bone|Giant Cell Bone Sarcoma|Giant Cell Sarcoma of Bone|Giant Cell Sarcoma of the Bone
C4305	Adamantinoma_of_Long_Bones	Adamantinoma	Adamantinoma of Long Bones
C4306	Benign_Odontogenic_Neoplasm	Odontogenic_Neoplasm	Benign Odontogenic Neoplasm|Benign Odontogenic Tumor
C4307	Dentinoma	Benign_Odontogenic_Neoplasm	Dentinoma
C4308	Benign_Cementoblastoma	Benign_Odontogenic_Neoplasm	Benign Cementoblastoma
C4309	Complex_Odontoma	Odontoma	Complex Odontoma
C4310	Adenomatoid_Odontogenic_Tumor	Odontogenic_Neoplasm	Adenomatoid Odontogenic Tumor|Adenomatoid Odontogenic Neoplasm
C4311	Odontogenic_Ghost_Cell_Neoplasm	Odontogenic_Neoplasm	Odontogenic Ghost Cell Neoplasm|Odontogenic Ghost Cell Tumor
C4312	Malignant_Ameloblastoma	Ameloblastoma|Malignant_Odontogenic_Neoplasm	Malignant Ameloblastoma|Malignant Adamantinoma	A rare, well differentiated, cytologically benign ameloblastoma which paradoxically metastasizes. -- 2004
C4313	Ameloblastoma	Odontogenic_Neoplasm	Ameloblastoma|Adamantinoma|Odontoameloblastoma	The most common odontogenic tumor, arising from the epithelial component of the embryonic tooth and usually affecting the molar-ramus region of the mandible or maxilla.  Although most ameloblastomas are morphologically and clinically benign, they may cause extensive local destruction, recur, or metastasize. -- 2004
C4314	Odontogenic_Fibroma	Benign_Odontogenic_Neoplasm|Fibroma	Odontogenic Fibroma|Central Odontogenic Fibroma
C4315	Peripheral_Odontogenic_Fibroma	Benign_Odontogenic_Neoplasm|Fibroma	Peripheral Odontogenic Fibroma
C4316	Ameloblastic_Fibroma	Benign_Odontogenic_Neoplasm|Fibroma	Ameloblastic Fibroma
C4317	Ameloblastic_Fibrosarcoma	Malignant_Odontogenic_Neoplasm	Ameloblastic Fibrosarcoma|Ameloblastic Sarcoma|Odontogenic Fibrosarcoma
C4318	Gliomatosis_Cerebri	Central_Nervous_System_Neuroepithelial_Neoplasm_of_Uncertain_Origin|Malignant_Central_Nervous_System_Neoplasm	Gliomatosis Cerebri|Astrocytosis cerebri	Gliomatosis cerebri (WHO grade II) is a diffuse glial tumor which infiltrates the brain, extensively, involving more than two lobes. It is frequently bilateral and often extends to the infratentorial structures, even to the spinal cord. It is probably of astrocytic origin, although GFAP expression may be scant or absent. (Adapted form WHO.)
C4319	Papillary_Ependymoma	Ependymoma	Papillary Ependymoma	Papillary Ependymoma is a rare variant of Ependymoma characterized by well formed papillae. Tumor cell processes abutting capillaries are usually GFAP-positive.  Differential diagnoses include Choroid Plexus Papilloma, Papillary Meningioma and Metastatic Papillary Carcinomas. (Adapted from WHO)
C4320	Protoplasmic_Astrocytoma	Diffuse_Astrocytoma	Protoplasmic Astrocytoma|Protoplasmic Astrocytic Neoplasm|Protoplasmic Astrocytic Tumor	Protoplasmic Astrocytoma is a rare variant of Diffuse Astrocytoma. It is predominantly composed of neoplastic astrocytes showing a small cell body with few, flaccid processes with a low content of glial filaments and scant GFAP expression. This lesion is not well defined and is considered by some authors as an occasional histopathological feature rather than a reproducibly identifiable variant. When occurring in children, this neoplasm may be difficult to separate from Pilocytic Juvenile Astrocytoma. (Adapted from WHO.)
C4321	Gemistocytic_Astrocytoma	Diffuse_Astrocytoma	Gemistocytic Astrocytoma|Gemistocytic Astrocytic Neoplasm|Gemistocytic Astrocytic Tumor|Gemistocytoma	Gemistocytic Astrocytoma is a rare variant of Diffuse Astrocytoma. It is characterized by the presence of a conspicuous, though variable, fraction of gemistocytic neoplastic astrocytes. Gemistocytes are round to oval astrocytes with abundant, glassy, non-fibrillary cytoplasm which appears to displace the dark, angulated nucleus to the periphery of the cell. To make the diagnosis of Gemistocytic Astrocytoma, gemistocytes should amount to more than approximately 20% of all tumor cells. (Adapted from WHO.)
C4322	Fibrillary_Astrocytoma	Diffuse_Astrocytoma	Fibrillary Astrocytoma|Fibrillary Astrocytic Neoplasm|Fibrillary Astrocytic Neoplasms|Fibrillary Astrocytic Tumor|Fibrillary Astrocytic Tumors	Fibrillary Astrocytoma is the most frequent histological variant of Diffuse Astrocytoma. It is predominantly composed of fibrillary neoplastic astrocytes. Nuclear atypia is a diagnostic criterion but mitotic activity, necrosis and microvascular proliferation are absent. A single mitosis does not yet allow the diagnosis of anaplastic astrocytoma. The occasional or regional occurrence of gemistocytic neoplastic cells is compatible with the diagnosis of fibrillary astrocytoma. (WHO)
C4323	Pleomorphic_Xanthoastrocytoma	Astrocytic_Tumor	Pleomorphic Xanthoastrocytoma|Pleomorphic Xantho-Astrocytoma	Pleomorphic Xanthoastrocytoma is an astrocytic tumor with a relatively favorable prognosis (WHO grade II) and is typically encountered in children and young adults. It has a superficial location in the cerebral hemispheres and involvement of the meninges. Characteristic features include pleomorphic and lipidized cells expressing GFAP and often surrounded by a reticulin network as well as eosinophilic granular bodies. For lesions with significant mitotic activity (5 or more mitoses per 10 HPF) and/or with areas of necrosis, the designation "pleomorphic xanthoastrocytoma with anaplastic features" may be used. (WHO)
C4324	Astroblastoma	Central_Nervous_System_Neuroepithelial_Neoplasm_of_Uncertain_Origin	Astroblastoma	Astroblastoma is a rare glial neoplasm more commonly found in young adults. It is characterized by tumor cells with characteristics suggestive of an astrocytic origin (positive for GFAP), arranged perivascularly. The cells have broad, non-tapering processes radiating towards a central blood vessel. The biologic behavior of astroblastomas is variable, so no WHO grade has been established, yet. (Adapted from WHO.) NCIPDQ
C4325	Giant_Cell_Glioblastoma	Glioblastoma|Malignant_Giant_Cell_Neoplasm	Giant Cell Glioblastoma	A rare histological variant of Glioblastoma (WHO grade IV) with a predominance of bizarre, multinucleated giant cells, an occasionally abundant stromal reticulin network and a high frequency of TP53 mutations. (WHO)
C4326	Anaplastic_Oligodendroglioma	Malignant_Glioma|Oligodendroglial_Tumor	Anaplastic Oligodendroglioma|Malignant Oligodendroglioma|Oligodendroglioma, Malignant|Undifferentiated Oligodendroglioma|WHO Grade III Oligodendroglial Neoplasm|WHO Grade III Oligodendroglial Tumor	A WHO grade III oligodendroglioma with focal or diffuse malignant morphologic features (prominent nuclear pleomorphism, mitoses, and increased cellularity). --2004
C4327	Medulloepithelioma	Central_Nervous_System_Primitive_Neuroectodermal_Tumor	Medulloepithelioma|Central Nervous System Medulloepithelioma|Medulloepithelioma, Central Nervous System	Medulloepithelioma (WHO grade IV) is a rare, highly malignant embryonal brain tumor which affects young children.  Histologically, it is characterized by papillary, tubular or trabecular arrangements of neoplastic neuroepithelium mimicking the embryonic neural tube. (Adapted from WHO.)
C4328	Pacinian_Neurofibroma	Neurofibroma	Pacinian Neurofibroma
C4329	Meningothelial_Meningioma	Grade_I_Meningioma	Meningothelial Meningioma|Meningotheliomatous Meningioma	A WHO grade I classic and common variant of Meningioma. The tumor cells form lobules surrounded by thin, collagenous septa. The tumor cells are largely uniform, like normal arachnoid, with oval nuclei that may show central clearing. (Adapted from WHO 2000.) - 2004
C4330	Fibrous_Meningioma	Grade_I_Meningioma	Fibrous Meningioma|Fibroblastic Meningioma	A WHO grade I classic and common variant of meningioma, in which spindle-shaped cells resembling fibroblasts form parallel and interlacing bundles on a matrix with abundant collagen and reticulin. Whorl formation and psammoma bodies are infrequent. (Adapted from WHO 2000.) - 2004
C4331	Psammomatous_Meningioma	Grade_I_Meningioma	Psammomatous Meningioma	A WHO grade I meningioma showing many psammoma bodies that may become confluent, forming irregular calcified and occasionally, ossified masses. These tumors often occur in the thoracic spinal region, usually in middle-aged women. (Adapted from WHO 2000.) - 2004
C4332	Angiomatous_Meningioma	Grade_I_Meningioma	Angiomatous Meningioma	A WHO grade I meningioma showing a microscopically typical meningioma background with numerous blood vessels superimposed.  The vascular channels may be small- or medium-sized, and may be thin-walled or have hyalinized, thickened walls. (Adapted from WHO 2000.) - 2004
C4333	Transitional_Meningioma	Grade_I_Meningioma	Transitional Meningioma|Mixed Meningioma|Transitional (Mixed) Meningioma	A common WHO grade I meningioma with features transitional between those of meningothelial and fibrous meningioma. (Adapted from WHO 2000.) - 2004
C4334	Meningeal_Sarcomatosis	Meningeal_Sarcoma|Sarcomatosis	Meningeal Sarcomatosis|Meninges Sarcomatosis|Sarcomatosis of Meninges|Sarcomatosis of the Meninges	A rare condition characterized by diffuse spread of sarcoma cells throughout the meninges.  The neoplastic cells are derived from meningeal connective tissue.  Clinically, the disorder may present as a fulminant pachymeningitis and/or encephalitis.  (KEV 8-13-99)
C4335	Malignant_Triton_Tumor	Malignant_Peripheral_Nerve_Sheath_Tumor	Malignant Triton Tumor|MPNST with Rhabdomyosarcoma|Malignant Neoplasm of Peripheral Nerve Sheath with Rhabdomyosarcoma|Malignant Neoplasm of the Peripheral Nerve Sheath with Rhabdomyosarcoma|Malignant Peripheral Nerve Sheath Neoplasm with Rhabdomyosarcoma|Malignant Peripheral Nerve Sheath Tumor with Rhabdomyosarcoma|Malignant Tumor of Peripheral Nerve Sheath with Rhabdomyosarcoma|Malignant Tumor of the Peripheral Nerve Sheath with Rhabdomyosarcoma
C4336	Malignant_Granular_Cell_Tumor	Granular_Cell_Tumor	Malignant Granular Cell Tumor|Malignant Granular Cell Myoblastoma|Malignant Granular Cell Neoplasm
C4337	Mantle_Cell_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Mantle Cell Lymphoma|MCL|Mantle Zone Lymphoma	An aggressive, usually diffuse non-Hodgkin's lymphoma composed of monomorphic small to medium sized B-lymphocytes (centrocytes).  Most patients present with advanced stage disease with lymphadenopathy, hepatosplenomegaly, and bone marrow involvement.  Gastrointestinal tract is the most commonly affected extranodal site by this type of non-Hodgkin's lymphoma.  The vast majority of cases express the t(11;14)(q13;q32) resulting in the rearrangement of the BCL-1 gene and the overexpression of cyclin D1 mRNA.  -- 2004
C4338	Diffuse_Centroblastic-Centrocytic_Lymphoma	Lymphoma_Leukemia_by_Kiel_Classification_Antiquated	Diffuse Centroblastic-Centrocytic Lymphoma|CB/CC
C4339	Multifocal_Lymphomatous_Polyposis	Gastrointestinal_Non-Hodgkin_s_Lymphoma	Multifocal Lymphomatous Polyposis|Multiple Lymphomatous Polyposis	A clinico-pathological entity reflecting the multiple polyps throughout the gastrointestinal tract created as a result of involvement by a non-Hodgkin's lymphoma.  Typically, mantle cell lymphomas involving the gastrointestinal tract give rise to multifocal lymphomatous polyposis.  Importantly, other histologic subtypes of non-Hodgkin's lymphoma can also produce this clinico-pathological entity.  (WHO, 2000) -- 2003
C4340	Unspecified_Peripheral_T-Cell_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Unspecified Peripheral T-Cell Lymphoma|T-Immunoblastic Lymphoma	Aggressive nodal or extranodal mature (peripheral) T-cell lymphomas that do not belong to the better defined entities of the remainder of mature T-cell lymphomas.  This category includes the lymphoepithelioid cell variant of mature T-cell lymphoma (Lennert's lymphoma) and the T-zone variant of mature T-cell lymphoma.--2004
C4341	Marginal_Zone_B-Cell_Lymphoma	Indolent_Non-Hodgkin_s_Lymphoma|Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Marginal Zone B-Cell Lymphoma|MZBCL|MZL|Marginal Zone Lymphoma
C4342	Intravascular_Large_B-Cell_Lymphoma	Diffuse_Large_B-Cell_Lymphoma	Intravascular Large B-Cell Lymphoma|Angiotropic Large Cell Lymphoma|Angiotropic Lymphoma|Intravascular B-Cell Lymphoma|Malignant Angioendotheliomatosis	A rare extranodal B-cell non-Hodgkin's lymphoma, characterized by the presence of lymphoma cells exclusively in the lumina of small vessels, particularly capillaries.  This is an extremely aggressive lymphoma which responds poorly to chemotherapy.  (WHO, 2001) -- 2003
C4343	Aleukemic_Lymphoid_Leukemia	Aleukemic_Leukemia|Lymphoid_Leukemia	Aleukemic Lymphoid Leukemia|Aleukemic Lymphatic Leukemia|Aleukemic Lymphogenous Leukemia
C4344	Acute_Panmyelosis_with_Myelofibrosis	Acute_Myeloid_Leukemia_not_Otherwise_Categorized	Acute Panmyelosis with Myelofibrosis|Acute Myelofibrosis|Acute Myelosclerosis|Acute Panmyelosis	An acute myeloid leukemia characterized by bone marrow fibrosis.  The prognosis is usually poor.  (WHO, 2001) -- 2003
C4345	Chronic_Myeloproliferative_Disorder	Myeloid_Neoplasm	Chronic Myeloproliferative Disorder|CMPD|Chronic Myeloproliferative Disease	Chronic myeloproliferative disorders (CMPDs) are clonal hematopoietic stem cell disorders, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, and megakaryocytic) lineages.  The proliferation is associated with relatively normal, effective maturation, resulting in increased numbers of granulocytes, red blood cells, and/or platelets in the peripheral blood.  CMPDs are primarily diseases of adults.  -- 2003
C4346	Sebaceous_Epithelioma	Benign_Sebaceous_Neoplasm|Epithelioma	Basosebaceous Epithelioma|Basal Cell Epithelioma with Sebaceous Differentiation|Sebaceous Epithelioma
C4347	Childhood_Cerebral_Astrocytoma	Cerebral_Astrocytoma|Childhood_Astrocytic_Tumor|Childhood_Supratentorial_Neoplasm	Childhood Cerebral Astrocytoma|Childhood Astrocytic Tumor of Cerebrum|Childhood Astrocytic Tumor of the Cerebrum|Childhood Astrocytoma of Cerebrum|Childhood Astrocytoma of the Cerebrum|Childhood Cerebral Astrocytic Neoplasm|Childhood Cerebral Astrocytic Tumor|Pediatric Astrocytic Tumor of Cerebrum|Pediatric Astrocytic Tumor of the Cerebrum|Pediatric Astrocytoma of Cerebrum|Pediatric Astrocytoma of the Cerebrum|Pediatric Cerebral Astrocytic Neoplasm|Pediatric Cerebral Astrocytic Tumor|Pediatric Cerebral Astrocytoma	An astrocytoma, without designation of benign or malignant, that is found in the supratentorial region. The infratentorial location is more common in children.
C4348	Non-Functioning_Pituitary_Gland_Adenoma	Non-Functioning_Pituitary_Gland_Neoplasm|Pituitary_Gland_Adenoma	Non-Functioning Pituitary Gland Adenoma|Functionless Adenoma of Pituitary|Functionless Adenoma of Pituitary Gland|Functionless Adenoma of the Pituitary|Functionless Adenoma of the Pituitary Gland|Functionless Pituitary Adenoma|Functionless Pituitary Gland Adenoma|Non-Functioning Adenoma of Pituitary|Non-Functioning Adenoma of Pituitary Gland|Non-Functioning Adenoma of the Pituitary|Non-Functioning Adenoma of the Pituitary Gland|Non-Functioning Pituitary Adenoma|Non-Secretory Adenoma of Pituitary|Non-Secretory Adenoma of Pituitary Gland|Non-Secretory Adenoma of the Pituitary|Non-Secretory Adenoma of the Pituitary Gland|Non-Secretory Pituitary Adenoma|Non-Secretory Pituitary Gland Adenoma	A hormone producing or non-producing pituitary gland adenoma not associated with a hormonal syndrome. (NCI05)
C4349	Colon_Adenocarcinoma	Colon_Carcinoma|Colorectal_Adenocarcinoma	Colon Adenocarcinoma|Adenocarcinoma of Colon|Adenocarcinoma of the Colon|Colonic Adenocarcinoma
C4350	Limbic_Encephalitis	Paraneoplastic_Syndrome	Limbic Encephalitis
C4351	Choroid_Plexus_Cyst	Central_Nervous_System_Cyst	Choroid Plexus Cyst|Cyst of Choroid Plexus|Cyst of the Choroid Plexus
C4352	Ependymal_Cyst	Central_Nervous_System_Cyst	Ependymal Cyst
C4354	Benign_Eyelid_Neoplasm	Eyelid_Neoplasm	Benign Eyelid Neoplasm|Benign Eyelid Tumor|Benign Neoplasm of Eyelid|Benign Neoplasm of the Eyelid|Benign Tumor of Eyelid|Benign Tumor of the Eyelid
C4355	Eyelid_Squamous_Cell_Papilloma	Eyelid_Papilloma	Eyelid Squamous Cell Papilloma|Epidermoid Papilloma of Eyelid|Epidermoid Papilloma of the Eyelid|Eyelid Epidermoid Papilloma|Squamous Cell Papilloma of Eyelid|Squamous Cell Papilloma of the Eyelid
C4356	Eyelid_Seborrheic_Keratosis	Seborrheic_Keratosis	Eyelid Seborrheic Keratosis|Basal Cell Papilloma of Eyelid|Basal Cell Papilloma of the Eyelid|Eyelid Basal Cell Papilloma|Seborrheic Keratosis of Eyelid|Seborrheic Keratosis of the Eyelid
C4357	Eyelid_Capillary_Hemangioma	Benign_Eyelid_Neoplasm|Capillary_Hemangioma	Eyelid Capillary Hemangioma|Capillary Angioma of Eyelid|Capillary Angioma of Lid|Capillary Angioma of the Eyelid|Capillary Angioma of the Lid|Capillary Hemangioma of Eyelid|Capillary Hemangioma of Lid|Capillary Hemangioma of the Eyelid|Capillary Hemangioma of the Lid|Eyelid Capillary Angioma
C4358	Eyelid_Melanoma	Ocular_Melanoma	Eyelid Melanoma|Malignant Eyelid Melanoma|Malignant Melanoma of Eyelid|Malignant Melanoma of the Eyelid|Melanoma of Eyelid|Melanoma of the Eyelid
C4359	Lacrimal_Gland_Cyst	Cyst|Head_and_Neck_Finding	Lacrimal Gland Cyst|Cyst of Lacrimal Gland|Cyst of the Lacrimal Gland
C4360	Lacrimal_Gland_Neoplasm	Lacrimal_System_Neoplasm	Lacrimal Gland Neoplasm|Lacrimal Gland Tumor|Neoplasm of Lacrimal Gland|Neoplasm of the Lacrimal Gland|Tumor of Lacrimal Gland|Tumor of the Lacrimal Gland
C4361	Corneal_Neoplasm	Corneal_Disorder|Eye_Neoplasm	Corneal Neoplasm|Cornea Neoplasm|Cornea Tumor|Corneal Tumor|Neoplasm of Cornea|Neoplasm of the Cornea|Tumor of Cornea|Tumor of the Cornea
C4362	Iris_Miotic_Cyst	Iris_Cyst	Iris Miotic Cyst|Miotic Cyst of Iris|Miotic Cyst of the Iris
C4363	Ciliary_Body_Miotic_Cyst	Ciliary_Body_Cyst	Ciliary Body Miotic Cyst|Miotic Cyst of Ciliary Body|Miotic Cyst of the Ciliary Body
C4364	Ciliary_Body_Neoplasm	Ciliary_Body_Disorder|Uveal_Neoplasm	Ciliary Body Neoplasm|Ciliary Body Tumor|Neoplasm of Ciliary Body|Neoplasm of the Ciliary Body|Tumor of Ciliary Body|Tumor of the Ciliary Body
C4365	Retinal_Lymphoma	Intraocular_Lymphoma|Malignant_Retinal_Neoplasm	Retinal Lymphoma|Lymphoma of Retina|Lymphoma of the Retina|Primary Retinal Lymphoma
C4366	External_Auditory_Canal_Polyp	Ear_Polyp	External Auditory Canal Polyp|Polyp of External Auditory Canal|Polyp of the External Auditory Canal
C4367	Frontal_Sinus_Polyp	Benign_Frontal_Sinus_Neoplasm|Paranasal_Sinus_Polyp	Frontal Sinus Polyp|Polyp of Frontal Sinus|Polyp of the Frontal Sinus
C4368	Nasal_Cavity_Cyst	Cyst|Head_and_Neck_Finding	Nasal Cavity Cyst|Cyst of Nasal Cavity|Cyst of the Nasal Cavity
C4369	Nasal_Vestibule_Squamous_Papilloma	Benign_Nasal_Cavity_Neoplasm|Squamous_Cell_Papilloma	Nasal Vestibule Squamous Papilloma|Nasal Vestibule Papilloma|Papilloma of Nasal Vestibule|Papilloma of the Nasal Vestibule|Squamous Papilloma of Nasal Vestibule|Squamous Papilloma of the Nasal Vestibule
C4370	Skin_Lymphangioleiomyomatosis	Cutaneous_Vascular_Neoplasm|Lymphangiomyomatosis	Skin Lymphangioleiomyomatosis|Lymphangioleiomyomatosis of Skin|Lymphangioleiomyomatosis of the Skin
C4371	Pregnancy_Associated_Hypertension	Hypertension	Pregnancy Associated Hypertension|Pregnancy Induced Hypertension
C4372	Cherry_Hemangioma_of_Lip	Benign_Lip_Neoplasm|Cherry_Hemangioma	Cherry Hemangioma of Lip|Senile Hemangioma of Lip
C4373	Gastric_Hamartoma	Benign_Gastric_Neoplasm|Hamartoma	Gastric Hamartoma|Hamartoma of Stomach|Hamartoma of the Stomach
C4374	Pancreatic_Cystadenoma	Benign_Exocrine_Pancreatic_Neoplasm|Cystadenoma	Pancreatic Cystadenoma|Cystadenoma of Pancreas|Cystadenoma of the Pancreas
C4375	Islet_Cell_Adenomatosis	Endocrine_Pancreas_Disorder	Nesidioblastosis|Islet Cell Adenomatosis
C4376	Renal_Failure	Non-Neoplastic_Renal_Disorder	Renal Failure|Impaired Renal Function	Acute or chronic condition, characterized by the inability of the kidneys to adequately filter the blood substances, resulting in uremia and electrolyte imbalances.  Acute renal failure is usually associated with oliguria or anuria, hyperkalemia, and pulmonary edema.  Chronic renal failure is irreversible and requires hemodialysis.--2004
C4377	Adult_Fanconi_Anemia	Fanconi_Syndrome	Adult Fanconi Anemia|Adult Fanconi Syndrome|Adult Fanconi's Syndrome	Probably related to a recessive gene, this is Fanconi Syndrome, characterised by adult onset. -- 2003
C4378	Paraurethral_Gland_Neoplasm	Urethra_Neoplasm	Paraurethral Gland Neoplasm|Neoplasm of Paraurethral Gland|Neoplasm of the Paraurethral Gland|Paraurethral Gland Tumor|Tumor of Paraurethral Gland|Tumor of the Paraurethral Gland
C4379	Scrotal_Sebaceous_Cyst	Scrotal_Cyst|Sebaceous_Cyst	Scrotal Sebaceous Cyst|Keratinous Cyst of Scrotum|Keratinous Cyst of the Scrotum|Sebaceous Cyst of Scrotum|Sebaceous Cyst of the Scrotum
C4380	Scrotal_Neoplasm	Skin_Neoplasm	Scrotal Neoplasm|Neoplasm of Scrotum|Neoplasm of the Scrotum|Scrotal Tumor|Tumor of Scrotum|Tumor of the Scrotum
C4381	Ovarian_Epithelial_Neoplasm	Epithelial_Neoplasm|Ovarian_Neoplasm	Ovarian Surface Epithelial-Stromal Tumor|Epithelial Neoplasm of Ovary|Epithelial Neoplasm of the Ovary|Epithelial Tumor of Ovary|Epithelial Tumor of the Ovary|Ovarian Epithelial Tumor|Ovarian Surface-Epithelial Stromal Neoplasm
C4382	Vulvar_Condyloma_Acuminatum	Condyloma_Acuminatum|Vulvar_Squamous_Neoplasm	Vulvar Condyloma Acuminatum|Condylomata Acuminata of Vulva|Condylomata Acuminata of the Vulva|Vulvar Condyloma
C4383	Erosive_Nipple_Adenomatosis	Benign_Nipple_Neoplasm	Erosive Nipple Adenomatosis|Erosive Adenomatosis of Nipple|Erosive Adenomatosis of the Nipple
C4384	Parathyroid_Cyst	Cyst|Endocrine_System_Finding	Parathyroid Cyst|Cyst of Parathyroid|Cyst of the Parathyroid
C4385	Hypothalamic_Hamartoma	Brain_Hamartoma	Hypothalamic Hamartoma|Hamartoma of Hypothalamus|Hamartoma of the Hypothalamus
C4386	Adrenal_Cyst	Cyst|Endocrine_System_Finding	Adrenal Cyst
C4387	Ectopic_ACTH_Syndrome	Ectopic_Hormone_Secretion_Syndromes_Associated_with_Neoplasia	Ectopic ACTH Syndrome|Ectopic ACTH Secretion	Abnormal secretion of adrenocorticotrophic hormone in conjunction with neoplastic growth occurring anywhere in the body. The most common associations are tumors of the bronchus (oat cell or carcinoid), thymic tumors (epithelial or carcinoid), pancreatic endocrine tumor. (DeVita et al. Cancer, p 1364. 4th edition. Lippincott)
C4389	Thiopurine_Methyltransferase_Deficiency	Enzyme_Deficiency	Thiopurine Methyltransferase Deficiency|TPMT Deficiency
C4390	Cherry_Hemangioma	Capillary_Hemangioma	Cherry Hemangioma|Cherry Angioma|Senile Angioma|Senile Hemangioma
C4391	Papillary_Endothelial_Hyperplasia	Reactive_Vascular_Proliferation	Papillary Endothelial Hyperplasia|Intravascular Papillary Endothelial Hyperplasia|Masson's Pseudosarcoma|Masson's Pseudotumor|Masson's Vegetant Hemangioma
C4392	Cervical_Symmetrical_Lipomatosis	Lipomatosis	Cervical Symmetrical Lipomatosis|Madelung's Disease
C4393	Senile_Nevus	Non-Neoplastic_Nevus	Senile Nevus
C4394	Anogenital_Papillomaviral_Intraepithelial_Neoplasia	Squamous_Cell_Intraepithelial_Neoplasia	Anogenital Papillomaviral Intraepithelial Neoplasia
C4395	Hepatic_Schistosomal_Granuloma	Hepatic_Granuloma|Schistosome_Granuloma	Hepatic Schistosomal Granuloma
C4396	Malignant_Adrenal_Medulla_Neoplasm	Adrenal_Medulla_Neoplasm|Malignant_Adrenal_Gland_Neoplasm	Malignant Adrenal Medulla Neoplasm|Malignant Adrenal Medulla Tumor|Malignant Neoplasm of Adrenal Medulla|Malignant Neoplasm of the Adrenal Medulla|Malignant Tumor of Adrenal Medulla|Malignant Tumor of the Adrenal Medulla	A primary or metastatic malignant neoplasm affecting the adrenal medulla. (NCI05)
C4397	Carcinoma_Ex_Pleomorphic_Adenoma	Carcinoma|Malignant_Mixed_Neoplasm	Carcinoma ex Pleomorphic Adenoma|Carcinoma in Pleomorphic Adenoma
C4398	Spinal_Arachnoid_Cyst	Arachnoid_Cyst|Spinal_Meningeal_Cyst	Spinal Arachnoid Cyst|Cyst of Spinal Arachnoid|Cyst of the Spinal Arachnoid
C4399	Salmon_Patch_Nevus	Retired_Concepts	Salmon Patch Nevus|Stork Bite|Unna's Nevus
C4400	Posterior_Tongue_Neoplasm	Oropharyngeal_Neoplasm|Tongue_Neoplasm	Posterior Tongue Neoplasm|Base of Tongue Neoplasm|Base of Tongue Tumor|Base of the Tongue Neoplasm|Base of the Tongue Tumor|Neoplasm of Base of Tongue|Neoplasm of Posterior Tongue|Neoplasm of the Base of the Tongue|Neoplasm of the Posterior Tongue|Posterior Tongue Tumor|Tumor of Base of Tongue|Tumor of Posterior Tongue|Tumor of the Base of the Tongue|Tumor of the Posterior Tongue
C4401	Floor_of_the_Mouth_Neoplasm	Oral_Cavity_Neoplasm	Floor of the Mouth Neoplasm|Floor of Mouth Neoplasm|Floor of Mouth Tumor|Floor of the Mouth Tumor|Neoplasm of Floor of Mouth|Neoplasm of the Floor of the Mouth|Tumor of Floor of Mouth|Tumor of the Floor of the Mouth
C4402	Palate_Neoplasm	Oral_Cavity_Neoplasm	Palate Neoplasm|Neoplasm of Palate|Neoplasm of the Palate|Palate Tumor|Tumor of Palate|Tumor of the Palate
C4403	Benign_Hard_Palate_Neoplasm	Benign_Oral_Cavity_Neoplasm|Benign_Palate_Neoplasm	Benign Hard Palate Neoplasm|Benign Hard Palate Tumor|Benign Neoplasm of Hard Palate|Benign Neoplasm of the Hard Palate|Benign Tumor of Hard Palate|Benign Tumor of the Hard Palate
C4404	Benign_Soft_Palate_Neoplasm	Benign_Palate_Neoplasm	Benign Soft Palate Neoplasm|Benign Neoplasm of Soft Palate|Benign Neoplasm of the Soft Palate|Benign Soft Palate Tumor|Benign Tumor of Soft Palate|Benign Tumor of the Soft Palate
C4405	Buccal_Mucosa_Neoplasm	Oral_Cavity_Neoplasm	Buccal Mucosa Neoplasm|Buccal Mucosa Tumor|Neoplasm of Buccal Mucosa|Neoplasm of the Buccal Mucosa|Tumor of Buccal Mucosa|Tumor of the Buccal Mucosa
C4406	Benign_Buccal_Mucosa_Neoplasm	Benign_Oral_Cavity_Neoplasm|Buccal_Mucosa_Neoplasm	Benign Buccal Mucosa Neoplasm|Benign Buccal Mucosa Tumor|Benign Neoplasm of Buccal Mucosa|Benign Neoplasm of the Buccal Mucosa|Benign Tumor of Buccal Mucosa|Benign Tumor of the Buccal Mucosa
C4407	Major_Salivary_Gland_Neoplasm	Salivary_Gland_Neoplasm	Major Salivary Gland Neoplasm|Major Salivary Gland Tumor|Neoplasm of Major Salivary Gland|Neoplasm of the Major Salivary Gland|Tumor of Major Salivary Gland|Tumor of the Major Salivary Gland
C4408	Benign_Posterior_Tongue_Neoplasm	Benign_Oropharyngeal_Neoplasm|Benign_Tongue_Neoplasm|Posterior_Tongue_Neoplasm	Benign Posterior Tongue Neoplasm|Benign Base of Tongue Neoplasm|Benign Base of Tongue Tumor|Benign Base of the Tongue Neoplasm|Benign Base of the Tongue Tumor|Benign Neoplasm of Base of Tongue|Benign Neoplasm of Posterior Tongue|Benign Neoplasm of the Base of the Tongue|Benign Neoplasm of the Posterior Tongue|Benign Posterior Tongue Tumor|Benign Tumor of Base of Tongue|Benign Tumor of Posterior Tongue|Benign Tumor of the Base of the Tongue|Benign Tumor of the Posterior Tongue
C4409	Minor_Salivary_Gland_Neoplasm	Salivary_Gland_Neoplasm	Minor Salivary Gland Neoplasm|Minor Salivary Gland Tumor|Neoplasm of Minor Salivary Gland|Neoplasm of the Minor Salivary Gland|Tumor of Minor Salivary Gland|Tumor of the Minor Salivary Gland
C4410	Malignant_Minor_Salivary_Gland_Neoplasm	Malignant_Salivary_Gland_Neoplasm|Minor_Salivary_Gland_Neoplasm	Malignant Minor Salivary Gland Neoplasm|Malignant Minor Salivary Gland Tumor|Malignant Neoplasm of Minor Salivary Gland|Malignant Neoplasm of the Minor Salivary Gland|Malignant Tumor of Minor Salivary Gland|Malignant Tumor of the Minor Salivary Gland
C4411	Benign_Minor_Salivary_Gland_Neoplasm	Benign_Salivary_Gland_Neoplasm|Minor_Salivary_Gland_Neoplasm	Benign Minor Salivary Gland Neoplasm|Benign Minor Salivary Gland Tumor|Benign Neoplasm of Minor Salivary Gland|Benign Neoplasm of the Minor Salivary Gland|Benign Tumor of Minor Salivary Gland|Benign Tumor of the Minor Salivary Gland
C4412	Middle_Ear_Neoplasm	Ear_Neoplasm|Middle_Ear_Disorder	Middle Ear Neoplasm|Middle Ear Tumor|Neoplasm of Middle Ear|Neoplasm of the Middle Ear|Tumor of Middle Ear|Tumor of the Middle Ear
C4413	Nasal_Cavity_Neoplasm	Nasal_Cavity_Disorder|Nasal_Cavity_and_Paranasal_Sinus_Neoplasm	Nasal Cavity Neoplasm|Nasal Cavity Tumor|Neoplasm of Nasal Cavity|Neoplasm of the Nasal Cavity|Tumor of Nasal Cavity|Tumor of the Nasal Cavity
C4414	Benign_Maxillary_Sinus_Neoplasm	Benign_Paranasal_Sinus_Neoplasm|Maxillary_Sinus_Neoplasm	Benign Maxillary Sinus Neoplasm|Benign Maxillary Antrum Neoplasm|Benign Maxillary Antrum Tumor|Benign Maxillary Sinus Tumor|Benign Maxillofacial Sinus Neoplasm|Benign Maxillofacial Sinus Tumor|Benign Neoplasm of Maxillary Antrum|Benign Neoplasm of Maxillary Sinus|Benign Neoplasm of Maxillofacial Sinus|Benign Neoplasm of the Maxillary Antrum|Benign Neoplasm of the Maxillary Sinus|Benign Neoplasm of the Maxillofacial Sinus|Benign Tumor of Maxillary Antrum|Benign Tumor of Maxillary Sinus|Benign Tumor of Maxillofacial Sinus|Benign Tumor of the Maxillary Antrum|Benign Tumor of the Maxillary Sinus|Benign Tumor of the Maxillofacial Sinus
C4416	Ethmoid_Sinus_Neoplasm	Paranasal_Sinus_Neoplasm	Ethmoid Sinus Neoplasm|Ethmoid Sinus Tumor|Ethmoidal Sinus Neoplasm|Ethmoidal Sinus Tumor|Neoplasm of Ethmoid Sinus|Neoplasm of Ethmoidal Sinus|Neoplasm of the Ethmoid Sinus|Neoplasm of the Ethmoidal Sinus|Tumor of Ethmoid Sinus|Tumor of Ethmoidal Sinus|Tumor of the Ethmoid Sinus|Tumor of the Ethmoidal Sinus
C4417	Benign_Ethmoid_Sinus_Neoplasm	Benign_Paranasal_Sinus_Neoplasm|Ethmoid_Sinus_Neoplasm	Benign Ethmoid Sinus Neoplasm|Benign Ethmoid Sinus Tumor|Benign Ethmoidal Sinus Neoplasm|Benign Ethmoidal Sinus Tumor|Benign Neoplasm of Ethmoid Sinus|Benign Neoplasm of Ethmoidal Sinus|Benign Neoplasm of the Ethmoid Sinus|Benign Neoplasm of the Ethmoidal Sinus|Benign Tumor of Ethmoid Sinus|Benign Tumor of Ethmoidal Sinus|Benign Tumor of the Ethmoid Sinus|Benign Tumor of the Ethmoidal Sinus
C4419	Frontal_Sinus_Neoplasm	Paranasal_Sinus_Neoplasm	Frontal Sinus Neoplasm|Frontal Sinus Tumor|Neoplasm of Frontal Sinus|Neoplasm of the Frontal Sinus|Tumor of Frontal Sinus|Tumor of the Frontal Sinus
C4420	Benign_Frontal_Sinus_Neoplasm	Benign_Paranasal_Sinus_Neoplasm|Frontal_Sinus_Neoplasm	Benign Frontal Sinus Neoplasm|Benign Frontal Sinus Tumor|Benign Neoplasm of Frontal Sinus|Benign Neoplasm of the Frontal Sinus|Benign Tumor of Frontal Sinus|Benign Tumor of the Frontal Sinus
C4422	Benign_Sphenoid_Sinus_Neoplasm	Benign_Paranasal_Sinus_Neoplasm|Sphenoid_Sinus_Neoplasm	Benign Sphenoid Sinus Neoplasm|Benign Neoplasm of Sphenoid Sinus|Benign Neoplasm of Sphenoidal Sinus|Benign Neoplasm of the Sphenoid Sinus|Benign Neoplasm of the Sphenoidal Sinus|Benign Sphenoid Sinus Tumor|Benign Sphenoidal Sinus Neoplasm|Benign Sphenoidal Sinus Tumor|Benign Tumor of Sphenoid Sinus|Benign Tumor of Sphenoidal Sinus|Benign Tumor of the Sphenoid Sinus|Benign Tumor of the Sphenoidal Sinus
C4424	Pyriform_Fossa_Neoplasm	Hypopharyngeal_Neoplasm	Pyriform Fossa Neoplasm|Neoplasm of Pyriform Fossa|Neoplasm of Pyriform Sinus|Neoplasm of the Pyriform Fossa|Neoplasm of the Pyriform Sinus|Pyriform Fossa Tumor|Pyriform Sinus Neoplasm|Pyriform Sinus Tumor|Tumor of Pyriform Fossa|Tumor of Pyriform Sinus|Tumor of the Pyriform Fossa|Tumor of the Pyriform Sinus
C4425	Glottis_Neoplasm	Laryngeal_Neoplasm	Glottis Neoplasm|Glottis Tumor|Neoplasm of Glottis|Neoplasm of the Glottis|Tumor of Glottis|Tumor of the Glottis
C4426	Subglottis_Neoplasm	Laryngeal_Neoplasm	Subglottis Neoplasm|Neoplasm of Subglottis|Neoplasm of the Subglottis|Subglottic Neoplasm|Subglottic Tumor|Subglottis Tumor|Tumor of Subglottis|Tumor of the Subglottis
C4427	Benign_Subglottis_Neoplasm	Benign_Laryngeal_Neoplasm|Subglottis_Neoplasm	Benign Subglottis Neoplasm|Benign Neoplasm of Subglottis|Benign Neoplasm of the Subglottis|Benign Subglottic Neoplasm|Benign Subglottic Tumor|Benign Subglottis Tumor|Benign Tumor of Subglottis|Benign Tumor of the Subglottis
C4428	Gastric_Cardia_Carcinoma_in_situ	Gastric_Cardia_Carcinoma|Stage_0_Gastric_Cancer	Gastric Cardia Carcinoma In Situ|Carcinoma in situ of Cardia of Stomach|Carcinoma in situ of Gastric Cardia|Carcinoma in situ of the Cardia of the Stomach|Carcinoma in situ of the Gastric Cardia|Stage 0 Gastric Cardia Carcinoma
C4429	Gastric_Fundus_Carcinoma_in_situ	Gastric_Fundus_Carcinoma|Stage_0_Gastric_Cancer	Gastric Fundus Carcinoma In Situ|Carcinoma in situ of Fundus of Stomach|Carcinoma in situ of Gastric Fundus|Carcinoma in situ of the Fundus of the Stomach|Carcinoma in situ of the Gastric Fundus|Stage 0 Gastric Fundus Carcinoma
C4430	Gastric_Body_Carcinoma_in_situ	Gastric_Body_Carcinoma|Stage_0_Gastric_Cancer	Gastric Body Carcinoma In Situ|Carcinoma in situ of Body of Stomach|Carcinoma in situ of Gastric Body|Carcinoma in situ of the Body of the Stomach|Carcinoma in situ of the Gastric Body|Stage 0 Gastric Body Carcinoma
C4431	Gastric_Pylorus_Carcinoma_in_situ	Gastric_Pylorus_Carcinoma|Stage_0_Gastric_Cancer	Gastric Pylorus Carcinoma In Situ|Carcinoma in situ of Gastric Pylorus|Carcinoma in situ of Pylorus of Stomach|Carcinoma in situ of the Gastric Pylorus|Carcinoma in situ of the Pylorus of the Stomach|Stage 0 Gastric Pylorus Carcinoma
C4432	Small_Intestinal_Neoplasm	Intestinal_Neoplasm	Small Intestinal Neoplasm|Neoplasm of Small Bowel|Neoplasm of Small Intestine|Neoplasm of the Small Bowel|Neoplasm of the Small Intestine|Small Bowel Neoplasm|Small Bowel Tumor|Small Intestine Neoplasm|Small Intestine Tumor|Tumor of Small Bowel|Tumor of Small Intestine|Tumor of the Small Bowel|Tumor of the Small Intestine
C4433	Cecum_Neoplasm	Colon_Neoplasm	Cecum Neoplasm|Cecum Tumor|Neoplasm of Cecum|Neoplasm of the Cecum|Tumor of Cecum|Tumor of the Cecum
C4434	Appendix_Neoplasm	Gastrointestinal_Neoplasm	Appendix Neoplasm|Appendix Tumor|Neoplasm of Appendix|Neoplasm of the Appendix|Tumor of Appendix|Tumor of the Appendix
C4435	Anal_Fibrous_Polyp	Anal_Polyp|Fibrous_Polyp	Anal Fibrous Polyp|Fibrous Polyp of Anus|Fibrous Polyp of the Anus
C4436	Cholangiocarcinoma	Bile_Duct_Adenocarcinoma|Common_Carcinoma	Cholangiocarcinoma|Cholangiocellular Carcinoma|Cholangiosarcoma|cholangiosarcoma	(ko-LAN-jee-o-sar-KO-ma) A tumor of the connective tissues of the bile ducts.
C4437	Hepatic_Sarcoma	Hepatic_Disorder|Malignant_Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Soft_Tissue_Sarcoma	Hepatic Sarcoma|Liver Sarcoma|Sarcoma of Liver|Sarcoma of the Liver
C4438	Hepatic_Angiosarcoma	Angiosarcoma|Hepatic_Sarcoma	Hepatic Angiosarcoma|Angiosarcoma of Liver|Angiosarcoma of the Liver|Hemangiosarcoma of Liver|Hemangiosarcoma of the Liver|Hepatic Hemangiosarcoma|Liver Angiosarcoma|Liver Hemangiosarcoma|Primary Angiosarcoma of Liver|Primary Angiosarcoma of the Liver
C4439	Stage_0_Gallbladder_Cancer	Gallbladder_Carcinoma|Gastrointestinal_Carcinoma_in_situ	Stage 0 Gallbladder Cancer|Carcinoma in situ of Gallbladder|Carcinoma in situ of the Gallbladder|Gallbladder Cancer Stage 0|Gallbladder Carcinoma in situ|Stage 0 Carcinoma of Gallbladder|Stage 0 Carcinoma of the Gallbladder|Stage 0 Gallbladder Carcinoma	Stage 0 includes: (Tis, N0, M0).  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C4440	Benign_Gallbladder_Neoplasm	Benign_Gastrointestinal_Neoplasm|Gallbladder_Neoplasm	Benign Gallbladder Neoplasm|Benign Gallbladder Tumor|Benign Neoplasm of Gallbladder|Benign Neoplasm of the Gallbladder|Benign Tumor of Gallbladder|Benign Tumor of the Gallbladder|Gallbladder Benign Neoplasm|Gallbladder Benign Tumor
C4441	Extrahepatic_Bile_Duct_Neoplasm	Bile_Duct_Neoplasm	Extrahepatic Bile Duct Neoplasm|Extrahepatic Bile Duct Tumor|Neoplasm of Extrahepatic Bile Duct|Neoplasm of the Extrahepatic Bile Duct|Tumor of Extrahepatic Bile Duct|Tumor of the Extrahepatic Bile Duct
C4442	Stage_0_Extrahepatic_Bile_Duct_Cancer	Biliary_Tract_Intraepithelial_Neoplasia|Extrahepatic_Bile_Duct_Carcinoma|Grade_III_Glandular_Intraepithelial_Neoplasia	Stage 0 Extrahepatic Bile Duct Cancer|Carcinoma in situ of Extrahepatic Bile Duct|Carcinoma in situ of Extrahepatic Bile Ducts|Carcinoma in situ of Extrahepatic Biliary Ducts|Carcinoma in situ of the Extrahepatic Bile Duct|Extrahepatic Bile Duct Cancer Stage 0|Extrahepatic Bile Duct Carcinoma in situ|Extrahepatic Biliary Duct Carcinoma in situ|Stage 0 Carcinoma of Extrahepatic Bile Duct|Stage 0 Carcinoma of the Extrahepatic Bile Duct|Stage 0 Extrahepatic Bile Duct Carcinoma	Stage 0 includes: (Tis, N0, M0).  Tis: Carcinoma in situ.  N0: No regional metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003
C4443	Ampulla_of_Vater_Neoplasm	Gastrointestinal_Neoplasm	Ampulla of Vater Neoplasm|Ampulla of Vater Tumor|Neoplasm of Ampulla of Vater|Neoplasm of the Ampulla of Vater|Tumor of Ampulla of Vater|Tumor of the Ampulla of Vater
C4444	Stage_0_Ampulla_of_Vater_Cancer	Ampulla_of_Vater_Carcinoma|Gastrointestinal_Carcinoma_in_situ	Stage 0 Ampulla of Vater Cancer|Ampulla of Vater Cancer Stage 0|Ampulla of Vater Carcinoma in situ|Ampullary Carcinoma in Situ|Stage 0 Ampulla of Vater Carcinoma|Stage 0 Ampullary Carcinoma
C4445	Exocrine_Pancreas_Neoplasm	Pancreatic_Neoplasm	Pancreatic Exocrine Neoplasm|Exocrine Pancreas Neoplasm|Exocrine Pancreas Tumor|Neoplasm of Exocrine Pancreas|Neoplasm of the Exocrine Pancreas|Pancreatic Exocrine Tumor|Tumor of Exocrine Pancreas|Tumor of the Exocrine Pancreas
C4446	Pancreatic_Carcinoid_Tumor	Functioning_Well_Differentiated_Pancreatic_Endocrine_Carcinoma	Pancreatic Serotonin Producing Tumor|Carcinoid Neoplasm of Pancreas|Carcinoid Neoplasm of the Pancreas|Carcinoid Tumor of Pancreas|Carcinoid Tumor of the Pancreas|Pancreatic Carcinoid Tumor|Pancreatic Serotonin Producing Neoplasm|Serotonin-Producing Tumor of Pancreas|Serotonin-Producing Tumor of the Pancreas	A usually slow-growing, malignant pancreatic endocrine neoplasm that secretes serotonin.  When it metastasizes to the liver, it produces the clinical symptoms of the carcinoid syndrome.
C4447	Benign_Retroperitoneal_Neoplasm	Retroperitoneal_Neoplasm	Benign Retroperitoneal Neoplasm
C4448	Tracheal_Squamous_Cell_Carcinoma	Squamous_Cell_Carcinoma|Tracheal_Carcinoma	Tracheal Squamous Cell Carcinoma|Epidermoid Carcinoma of Trachea|Epidermoid Carcinoma of the Trachea|Squamous Cell Carcinoma of Trachea|Squamous Cell Carcinoma of the Trachea|Trachea Epidermoid Carcinoma|Trachea Squamous Cell Carcinoma|Tracheal Epidermoid Carcinoma
C4450	Large_Cell_Lung_Carcinoma	Large_Cell_Carcinoma|Non-Small_Cell_Lung_Carcinoma	Large Cell Lung Carcinoma|Anaplastic Lung Carcinoma|Large Cell Carcinoma of Lung|Large Cell Carcinoma of the Lung|Large Cell Undifferentiated Lung Carcinoma	A poorly differentiated non-small cell lung carcinoma composed of large polygonal cells without evidence of glandular or squamous differentiation.  There is a male predilection. (NCI05)
C4451	Clear_Cell_Lung_Carcinoma	Large_Cell_Lung_Carcinoma	Large Cell Lung Carcinoma, Clear Cell Variant|Clear Cell Carcinoma of Lung, Large Cell Type|Clear Cell Carcinoma of the Lung, Large Cell Type|Clear Cell Lung Carcinoma, Large Cell Type	A morphologic variant of large cell lung carcinoma characterized by a predominance of clear cells that may or may not contain glycogen. (NCI05)
C4452	Giant_Cell_Lung_Carcinoma	Lung_Sarcomatoid_Carcinoma	Lung Giant Cell Carcinoma|Giant Cell Carcinoma of Lung|Giant Cell Carcinoma of the Lung	A rare, aggressive, poorly differentiated morphologic variant of lung sarcomatoid carcinoma characterized by the presence of mononucleated and multinucleated pleomorphic neoplastic giant cells that lack cohesion. (NCI05)
C4453	Lung_Epithelioid_Hemangioendothelioma	Epithelioid_Hemangioendothelioma|Malignant_Lung_Neoplasm	Lung Epithelioid Hemangioendothelioma|Epithelioid Angioendothelioma of Lung|Epithelioid Angioendothelioma of the Lung|Epithelioid Hemangioendothelioma of Lung|Epithelioid Hemangioendothelioma of the Lung|Lung Epithelioid Angioendothelioma|Pulmonary Epithelioid Angioendothelioma|Pulmonary Epithelioid Hemangioendothelioma
C4454	Benign_Lung_Neoplasm	Benign_Respiratory_Tract_Neoplasm|Benign_Thoracic_Neoplasm|Lung_Neoplasm	Benign Lung Neoplasm|Benign Lung Tumor|Benign Neoplasm of Lung|Benign Neoplasm of the Lung|Benign Tumor of Lung|Benign Tumor of the Lung	Abnormal growth of cells comprising the tissues of the lung/pleura without evidence of malignancy
C4455	Lung_Adenoma	Adenoma|Benign_Lung_Neoplasm	Lung Adenoma|Adenoma of Lung|Adenoma of the Lung|Pulmonary Adenoma
C4456	Malignant_Mesothelioma	Mesothelioma	Malignant Mesothelioma|Malignant Mesothelial Neoplasm|Malignant Mesothelial Tumor|Malignant Neoplasm of Mesothelium|Malignant Neoplasm of the Mesothelium|Malignant Tumor of Mesothelium|Malignant Tumor of the Mesothelium|malignant mesothelioma	A malignant neoplasm of the pleura or peritoneum, arising from mesothelial cells.  It is associated with exposure to asbestos. -- 2003
C4457	Pleural_Fibroma	Benign_Pleural_Neoplasm|Solitary_Fibrous_Tumor	Pleural Solitary Fibrous Tumor|Fibroma of Pleura|Fibroma of the Pleura|Localized Fibrous Mesothelioma of Pleura|Localized Fibrous Mesothelioma of the Pleura|Pleural Fibroma|Pleural Submesothelial Fibroma|Solitary Fibrous Tumor of Pleura|Solitary Fibrous Tumor of the Pleura
C4458	Benign_Thymus_Neoplasm	Thymic_Neoplasm	Benign Thymus Neoplasm|Benign Neoplasm of Thymus|Benign Neoplasm of the Thymus|Benign Thymic Neoplasm|Benign Thymic Tumor|Benign Thymus Tumor|Benign Tumor of Thymus|Benign Tumor of the Thymus
C4459	Clear_Cell_Squamous_Cell_Skin_Carcinoma	Skin_Squamous_Cell_Carcinoma	Clear Cell Squamous Cell Skin Carcinoma|Clear Cell Squamous Cell Carcinoma of Skin|Clear Cell Squamous Cell Carcinoma of the Skin	A squamous cell carcinoma of the skin with a prominent clear cell component.
C4460	Acantholytic_Squamous_Cell_Skin_Carcinoma	Skin_Squamous_Cell_Carcinoma	Acantholytic Squamous Cell Skin Carcinoma|Acantholytic Squamous Cell Carcinoma of Skin|Acantholytic Squamous Cell Carcinoma of the Skin
C4461	Multiple_Self_Healing_Epithelioma_of_Ferguson-Smith	Keratoacanthoma	Multiple Self Healing Epithelioma of Ferguson-Smith|Ferguson-Smith Tumor
C4462	Squamous_Cell_Skin_Papilloma	Skin_Papilloma	Squamous Cell Skin Papilloma|Dyskeratotic Papilloma of Skin|Dyskeratotic Papilloma of the Skin|Dyskeratotic Skin Papilloma|Hyperkeratotic Papilloma of Skin|Hyperkeratotic Papilloma of the Skin|Hyperkeratotic Skin Papilloma|Parakeratotic Papilloma of Skin|Parakeratotic Papilloma of the Skin|Parakeratotic Skin Papilloma|Squamous Cell Papilloma of Skin|Squamous Cell Papilloma of the Skin
C4463	Skin_Appendage_Neoplasm	Skin_Neoplasm	Skin Appendage Neoplasm|Adnexal Neoplasm of skin|Adnexal Neoplasm of the skin|Adnexal Tumor of skin|Adnexal Tumor of the skin|Cutaneous Adnexal Neoplasm|Epidermal Appendage Neoplasm|Epidermal Appendage Tumor|Neoplasm of Epidermal Appendage|Neoplasm of Skin Appendage|Neoplasm of the Skin Appendage|Skin Appendage Tumor|Tumor of Epidermal Appendage|Tumor of Skin Appendage|Tumor of the Skin Appendage
C4465	Vellus_Hair_Cyst	Skin_Cyst	Vellus Hair Cyst
C4468	Pilar_Sheath_Acanthoma	Acanthoma|Benign_Outer_Hair_Sheath_and_Infundibulum_Neoplasm	Pilar Sheath Acanthoma|Acanthoma of Pilar Sheath|Acanthoma of the Pilar Sheath
C4469	Follicular_Infundibulum_Neoplasm	Benign_Outer_Hair_Sheath_and_Infundibulum_Neoplasm	Follicular Infundibulum Neoplasm|Basal Cell Hamartoma with Follicular Differentiation|Follicular Infundibulum Tumor|Neoplasm of the Follicular Infundibulum|Tumor of the Follicular Infundibulum
C4470	Perifollicular_Fibroma	Benign_Pilar-Associated_Mesenchyme_Neoplasm|Dermal_Fibroma	Perifollicular Fibroma|Trichoblastic Fibroma
C4471	Adenoid_Cystic_Skin_Carcinoma	Adenoid_Cystic_Carcinoma|Eccrine_Adenocarcinoma	Adenoid Cystic Skin Carcinoma|Adenoid Cystic Carcinoma of Skin|Adenoid Cystic Carcinoma of the Skin|Adenoid Cystic Cutaneous Carcinoma|Primary Cutaneous Adenocystic Carcinoma
C4472	Mucoepidermoid_Skin_Carcinoma	Eccrine_Adenocarcinoma|Mucoepidermoid_Carcinoma	Mucoepidermoid Skin Carcinoma|Mucoepidermoid Carcinoma of Skin|Mucoepidermoid Carcinoma of the Skin
C4473	Eccrine_Dermal_Duct_Neoplasm	Benign_Eccrine_Neoplasm|Poroma_Acrospiroma	Eccrine Dermal Duct Tumor|Dermal Duct Neoplasm|Dermal Duct Tumor|Eccrine Dermal Duct Neoplasm
C4474	Benign_Mixed_Tumor_of_the_Skin_Chondroid_Syringoma	Benign_Eccrine_Neoplasm|Mixed_Neoplasm	Benign Mixed Tumor of the Skin (Chondroid Syringoma)|Benign Mixed Tumor of Skin|Benign Mixed Tumor of Skin (Chondroid Syringoma)|Benign Mixed Tumor of the Skin|Chondroid Syringoma|Mixed Eccrine Neoplasm|Mixed Eccrine Neoplasm of Skin|Mixed Eccrine Neoplasm of the Skin|Mixed Eccrine Skin Neoplasm|Mixed Eccrine Skin Tumor|Mixed Eccrine Tumor|Mixed Eccrine Tumor of Skin|Mixed Eccrine Tumor of the Skin
C4475	Dermal_Neoplasm	Skin_Neoplasm	Dermal Neoplasm|Dermal Tumor|Neoplasm of Dermis|Neoplasm of the Dermis|Tumor of Dermis|Tumor of the Dermis
C4478	Skin_Verruciform_Xanthoma	Benign_Cutaneous_Fibrohistiocytic_Neoplasm|Xanthoma	Skin Verruciform Xanthoma|Cutaneous Verruciform Xanthoma|Verruciform Xanthoma|Verruciform Xanthoma of Skin|Verruciform Xanthoma of the Skin
C4479	Cutaneous_Neural_Neoplasm	Dermal_Neoplasm|Peripheral_Nervous_System_Neoplasm	Cutaneous Neural Neoplasm|Neural Neoplasm of Skin|Neural Neoplasm of the Skin|Neural Tumor of Skin|Neural Tumor of the Skin|Skin Neoplasm of Neural Origin|Skin Neural Neoplasm|Skin Neural Tumor|Skin Tumor of Neural Origin
C4480	Cutaneous_Smooth_Muscle_Neoplasm	Dermal_Neoplasm	Cutaneous Smooth Muscle Neoplasm|Cutaneous Neoplasm of Smooth Muscle Origin|Cutaneous Tumor of Smooth Muscle Origin|Skin Neoplasm of Smooth Muscle Origin|Skin Tumor of Smooth Muscle Origin|Smooth Muscle Skin Neoplasm
C4481	Cutaneous_Ganglioneuroma	Cutaneous_Neural_Neoplasm|Ganglioneuroma	Cutaneous Ganglioneuroma|Ganglioneuroma of Skin|Ganglioneuroma of the Skin|Skin Ganglioneuroma
C4482	Cutaneous_Leiomyoma	Benign_Dermal_Neoplasm|Cutaneous_Smooth_Muscle_Neoplasm|Leiomyoma	Cutaneous Leiomyoma|Leiomyoma Cutis|Leiomyoma of Skin|Leiomyoma of the Skin|Skin Leiomyoma
C4483	Dartoic_Leiomyoma	Leiomyoma	Dartoic Leiomyoma|Dartoic Myoma
C4484	Cutaneous_Leiomyosarcoma	Cutaneous_Smooth_Muscle_Neoplasm|Leiomyosarcoma|Skin_Sarcoma	Cutaneous Leiomyosarcoma|Leiomyosarcoma of Skin|Leiomyosarcoma of the Skin|Skin Leiomyosarcoma	A leiomyosarcoma affecting the hair-bearing parts of the extremities.  It is more commonly seen in males than females.  The survival rates are good, because of the superficial location. -- 2003
C4485	Cobb_s_Syndrome	Hereditary_Neoplastic_Syndrome	Cobb's Syndrome
C4486	Blue_Rubber_Bleb_Nevus	Congenital_Hemangioma	Blue Rubber Bleb Nevus|Bean Syndrome
C4487	Tufted_Hemangioma	Capillary_Hemangioma	Tufted Hemangioma|Angioblastoma of Nakagawa|Tufted Angioma|Tufted Angioma of Skin|Tufted Angioma of the Skin|Tufted Hemangioma of Skin|Tufted Hemangioma of the Skin|Tufted Skin Angioma
C4488	Skin_Angiokeratoma	Angiokeratoma	Skin Angiokeratoma|Angiokeratoma of Skin|Angiokeratoma of the Skin|Cutaneous Angiokeratoma
C4489	Skin_Angiosarcoma	Angiosarcoma|Malignant_Cutaneous_Vascular_Neoplasm|Skin_Sarcoma	Skin Angiosarcoma|Angiosarcoma of Skin|Angiosarcoma of the Skin|Hemangiosarcoma of Skin|Hemangiosarcoma of the Skin|Skin Hemangiosarcoma
C4490	Skin_Lymphangiosarcoma	Lymphangiosarcoma|Malignant_Cutaneous_Vascular_Neoplasm|Skin_Sarcoma	Skin Lymphangiosarcoma|Lymphangiosarcoma of Skin|Lymphangiosarcoma of Stewart and Treves|Lymphangiosarcoma of the Skin
C4491	Glomus_Tumor_of_the_Skin	Glomus_Tumor	Glomus Tumor of the Skin|Glomus Neoplasm of Skin|Glomus Neoplasm of the Skin|Glomus Skin Neoplasm|Glomus Skin Tumor|Glomus Tumor of Skin|Skin Glomus Neoplasm
C4492	Skin_Hemangiopericytoma	Hemangiopericytoma	Skin Hemangiopericytoma|Hemangiopericytoma of Skin|Hemangiopericytoma of the Skin
C4493	Malignant_Skin_Hemangiopericytoma	Malignant_Hemangiopericytoma|Malignant_Skin_Neoplasm|Skin_Hemangiopericytoma	Malignant Skin Hemangiopericytoma|Malignant Hemangiopericytoma of Skin|Malignant Hemangiopericytoma of the Skin
C4494	Skin_Hemangioendothelioma	Cutaneous_Vascular_Neoplasm|Hemangioendothelioma	Skin Hemangioendothelioma|Angioendothelioma of Skin|Angioendothelioma of the Skin|Hemangioendothelioma of Skin|Hemangioendothelioma of the Skin|Skin Angioendothelioma
C4495	Cockade_Nevus	Benign_Melanocytic_Nevus	Cockade Nevus
C4496	Common_Blue_Nevus	Blue_Nevus	Common Blue Nevus|Common Blue Nevus of Skin|Common Blue Nevus of the Skin
C4497	Desmoplastic_Nevus	Benign_Melanocytic_Nevus	Desmoplastic Nevus
C4498	Nevus_Spilus	Benign_Melanocytic_Nevus	Nevus Spilus|Speckled Lentiginous Nevus
C4499	Benign_Pleural_Mesothelioma	Adenomatoid_Tumor|Pleural_Mesothelioma	Pleural Adenomatoid Tumor|Benign Mesothelioma of Pleura|Benign Mesothelioma of the Pleura|Pleural Benign Mesothelioma|Pleural Mesothelioma, Benign
C4500	Benign_Pericardial_Mesothelioma	Retired_Concepts	Pericardial Solitary Fibrous Tumor|Benign Pericardial Mesothelial Neoplasm|Pericardial Benign Mesothelioma|Pericardial Fibrous Mesothelioma|Pericardial Submesothelial Fibroma
C4501	Malignant_Lipomatous_Neoplasm	Lipomatous_Neoplasm	Malignant Lipomatous Neoplasm|Malignant Adipose Tissue Neoplasm|Malignant Adipose Tissue Tumor|Malignant Lipomatous Tumor|Malignant Neoplasm of Adipose Tissue|Malignant Neoplasm of the Adipose Tissue|Malignant Tumor of Adipose Tissue|Malignant Tumor of the Adipose Tissue
C4502	Benign_Lipomatous_Neoplasm	Benign_Mesenchymal_Cell_Neoplasm|Lipomatous_Neoplasm	Benign Lipomatous Neoplasm|Benign Adipose Tissue Neoplasm|Benign Adipose Tissue Tumor|Benign Lipomatous Tumor|Benign Neoplasm of Adipose Tissue|Benign Neoplasm of the Adipose Tissue|Benign Tumor of Adipose Tissue|Benign Tumor of the Adipose Tissue	A benign tumor composed of adipose (fatty) tissue.  The most common representative of this category is the lipoma. -- 2003
C4503	Hereditary_Breast_Carcinoma	Breast_Carcinoma|Familial_Cancer	Hereditary Breast Carcinoma|Familial Breast Carcinoma|Familial Cancer of Breast|Familial Cancer of the Breast|Hereditary Breast Cancer
C4504	Malignant_Phyllodes_Breast_Tumor	Breast_Sarcoma|Malignant_Phyllodes_Tumor|Phyllodes_Tumor_of_the_Breast	Malignant Breast Phyllodes Tumor|Malignant Breast Phyllodes Neoplasm|Malignant Cystosarcoma Phyllodes of Breast|Malignant Cystosarcoma Phyllodes of the Breast|Malignant Mammary Phyllodes Neoplasm|Malignant Mammary Phyllodes Tumor|Malignant Phyllodes Breast Neoplasm|Malignant Phyllodes Neoplasm of Breast|Malignant Phyllodes Neoplasm of the Breast|Malignant Phyllodes Tumor of Breast|Malignant Phyllodes Tumor of the Breast
C4505	Benign_Breast_Neoplasm	Breast_Neoplasm	Benign Breast Neoplasm|Benign Breast Tumor|Benign Neoplasm of Breast|Benign Neoplasm of the Breast|Benign Tumor of Breast|Benign Tumor of the Breast	A non-metastasizing tumor arising from the breast parenchyma. -- 2003
C4506	Ovarian_Papillary_Cystadenocarcinoma	Retired_Concepts	Ovarian Papillary Cystadenocarcinoma|Ovarian Papillary Serous Cystadenocarcinoma|Ovarian Serous Papillary Cystadenocarcinoma|Serous Papillary Cystadenocarcinoma of Ovary|Serous Papillary Cystadenocarcinoma of the Ovary
C4508	Ovarian_Mixed_Epithelial_Neoplasm	Complex_Epithelial_Neoplasm|Ovarian_Epithelial_Neoplasm	Ovarian Mixed Epithelial Tumor|Mixed Epithelial Neoplasm of Ovary|Mixed Epithelial Neoplasm of the Ovary|Mixed Epithelial Tumor of Ovary|Mixed Epithelial Tumor of the Ovary|Ovarian Mixed Epithelial Neoplasm
C4509	Undifferentiated_Ovarian_Carcinoma	Ovarian_Carcinoma|Undifferentiated_Carcinoma	Undifferentiated Ovarian Carcinoma|Anaplastic Carcinoma of Ovary|Anaplastic Carcinoma of the Ovary|Anaplastic Ovarian Carcinoma|Undifferentiated Carcinoma of Ovary|Undifferentiated Carcinoma of the Ovary
C4510	Benign_Ovarian_Epithelial_Neoplasm	Benign_Epithelial_Neoplasm|Benign_Ovarian_Neoplasm|Ovarian_Epithelial_Neoplasm	Benign Ovarian Surface Epithelial-Stromal Tumor|Benign Epithelial Neoplasm of Ovary|Benign Epithelial Neoplasm of the Ovary|Benign Epithelial Tumor of Ovary|Benign Epithelial Tumor of the Ovary|Benign Ovarian Epithelial Neoplasm|Benign Ovarian Surface Epithelial Neoplasm|Benign Ovarian Surface Epithelial Tumor|Benign Surface Epithelial Neoplasm of Ovary|Benign Surface Epithelial Neoplasm of the Ovary|Benign Surface Epithelial Tumor of Ovary|Benign Surface Epithelial Tumor of the Ovary
C4511	Ovarian_Serous_Cystadenoma	Benign_Ovarian_Serous_Neoplasm|Ovarian_Cystadenoma|Serous_Cystadenoma	Ovarian Serous Cystadenoma|Benign Ovarian Serous Cystadenoma|Benign Serous Cystadenoma of Ovary|Benign Serous Cystadenoma of the Ovary|Serous Cystadenoma of Ovary|Serous Cystadenoma of the Ovary	Serous cystadenoma is a serous neoplasm in which the cysts and papillae are lined by a single layer of cells without atypia, architectural complexity or invasion. --2002
C4512	Ovarian_Mucinous_Cystadenoma	Benign_Ovarian_Mucinous_Tumor|Mucinous_Cystadenoma|Ovarian_Cystadenoma	Ovarian Mucinous Cystadenoma|Benign Mucinous Cystadenoma of Ovary|Benign Mucinous Cystadenoma of the Ovary|Benign Ovarian Mucinous Cystadenoma|Mucinous Cystadenoma of Ovary|Mucinous Cystadenoma of the Ovary
C4513	Ovarian_Gynandroblastoma	Retired_Concepts	Ovarian Gynandroblastoma|Gynandroblastoma of Ovary|Gynandroblastoma of the Ovary
C4514	Malignant_Ovarian_Germ_Cell_Tumor	Malignant_Germ_Cell_Neoplasm|Malignant_Ovarian_Neoplasm|Ovarian_Germ_Cell_Tumor	Malignant Ovarian Germ Cell Tumor|Malignant Germ Cell Neoplasm of Ovary|Malignant Germ Cell Neoplasm of the Ovary|Malignant Germ Cell Tumor of Ovary|Malignant Germ Cell Tumor of the Ovary|Malignant Ovarian Germ Cell Neoplasm|Ovarian Germ Cell Cancer	Malignant germ cell tumors which arise in the ovaries.
C4515	Ovarian_Choriocarcinoma	Choriocarcinoma|Malignant_Ovarian_Germ_Cell_Tumor	Ovarian Choriocarcinoma|Choriocarcinoma of Ovary|Choriocarcinoma of the Ovary|Germ Cell Choriocarcinoma of Ovary|Germ Cell Choriocarcinoma of the Ovary|Ovarian Germ Cell Choriocarcinoma
C4516	Benign_Ovarian_Germ_Cell_Neoplasm	Benign_Germ_Cell_Neoplasm|Benign_Ovarian_Neoplasm|Ovarian_Germ_Cell_Tumor	Benign Ovarian Germ Cell Tumor|Benign Germ Cell Neoplasm of Ovary|Benign Germ Cell Neoplasm of the Ovary|Benign Germ Cell Tumor of Ovary|Benign Germ Cell Tumor of the Ovary|Benign Ovarian Germ Cell Neoplasm|Benign Ovarian Germ Cell Neoplasms|Benign Ovarian Germ Cell Tumors|Germ Cell Neoplasms, Ovarian, Benign|Germ Cell Tumors, Ovarian, Benign|Ovarian Germ Cell Neoplasms, Benign|Ovarian Germ Cell Tumors, Benign
C4517	Benign_Fallopian_Tube_Neoplasm	Benign_Female_Reproductive_System_Neoplasm|Fallopian_Tube_Neoplasm	Benign Fallopian Tube Neoplasm|Benign Fallopian Tube Tumor|Benign Neoplasm of Fallopian Tube|Benign Neoplasm of the Fallopian Tube|Benign Tumor of Fallopian Tube|Benign Tumor of the Fallopian Tube|Fallopian Tube Neoplasm, Benign|Fallopian Tube Tumor, Benign
C4518	Intravenous_Leiomyomatosis	Leiomyomatosis	Intravenous Leiomyomatosis
C4519	Cervical_Adenosquamous_Carcinoma	Adenosquamous_Carcinoma|Cervical_Carcinoma	Cervical Adenosquamous Carcinoma|Adenosquamous Cell Carcinoma of Cervix|Adenosquamous Cell Carcinoma of Cervix Uteri|Adenosquamous Cell Carcinoma of Uterine Cervix|Adenosquamous Cell Carcinoma of the Cervix|Adenosquamous Cell Carcinoma of the Cervix Uteri|Adenosquamous Cell Carcinoma of the Uterine Cervix|Cervical Adenosquamous Cell Carcinoma|Cervix Adenosquamous Cell Carcinoma|Cervix Uteri Adenosquamous Cell Carcinoma|Uterine Cervix Adenosquamous Cell Carcinoma
C4520	Cervical_Adenocarcinoma_in_situ	Cervical_Adenocarcinoma|Grade_III_Glandular_Intraepithelial_Neoplasia|High_Grade_Cervical_Glandular_Intraepithelial_Neoplasia|Stage_0_Cervical_Cancer	Cervical Adenocarcinoma In Situ|Adenocarcinoma in situ of Cervix|Adenocarcinoma in situ of Cervix Uteri|Adenocarcinoma in situ of Uterine Cervix|Adenocarcinoma in situ of the Cervix|Adenocarcinoma in situ of the Cervix Uteri|Adenocarcinoma in situ of the Uterine Cervix|Cervix Adenocarcinoma in situ|Cervix Uteri Adenocarcinoma in situ|Uterine Cervix Adenocarcinoma in situ
C4521	Vaginal_Intraepithelial_Neoplasia	Female_Reproductive_System_Precancerous_Condition|Squamous_Cell_Intraepithelial_Neoplasia|Vaginal_Squamous_Neoplasm	Vaginal Intraepithelial Neoplasia|Intraepithelial Neoplasia of Vagina|Intraepithelial Neoplasia of the Vagina|Intraepithelial Neoplasm of Vagina|Intraepithelial Neoplasm of the Vagina|Intraepithelial Tumor of Vagina|Intraepithelial Tumor of the Vagina|VAIN|Vaginal Intraepithelial Neoplasm|Vaginal Intraepithelial Tumor	A superficial neoplastic process involving exclusively the vaginal squamous epithelium without extension to underlying tissue.  It is classified as low- or high-grade intraepithelial neoplasia.  --2003
C4522	Stage_0_Vulvar_Cancer	High_Grade_Vulvar_Intraepithelial_Neoplasia|Stage_0_Squamous_Cell_Carcinoma|Vulvar_Carcinoma	Stage 0 Vulvar Cancer|AJCC Stage 0 Vulvar Cancer|Carcinoma in situ of Vulva|Carcinoma in situ of the Vulva|FIGO Stage 0 Carcinoma of Vulva|FIGO Stage 0 Carcinoma of the Vulva|FIGO Stage 0 Vulva Carcinoma|FIGO Stage 0 Vulvar Carcinoma|Intraepithelial Neoplasia of Vulva Grade 3|Intraepithelial Neoplasia of the Vulva Grade 3|Severe Intraepithelial Neoplasia of Vulva|Severe Intraepithelial Neoplasia of the Vulva|Severe VIN|Severe Vulvar Intraepithelial Neoplasia|Stage 0 Vulval Cancer|Stage 0 Vulval Carcinoma|Stage 0 Vulvar Carcinoma|VIN 3|VIN Grade 3|Vulva Carcinoma in situ|Vulvar Cancer Stage 0|Vulvar Carcinoma in situ|Vulvar Intraepithelial Neoplasia Grade 3	Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ (preinvasive carcinoma. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C4523	Stage_0_Testicular_Cancer	Malignant_Testicular_Germ_Cell_Tumor	Stage 0 Testicular Cancer|Stage 0 Cancer of Testis|Stage 0 Cancer of the Testis|Stage 0 Testicular Germ Cell Tumor|Testicular Carcinoma in Situ	Stage 0 includes: pTis, N0, M0, S0.  pTis: Intratubular germ cell neoplasia (carcinoma in situ).  N0: regional lymph node metastasis.  M0: No distant metastasis.  S0: Marker study levels within normal limits. (AJCC 6th ed) - 2003
C4524	Multilocular_Cystic_Renal_Cell_Carcinoma	Renal_Cell_Carcinoma	Multilocular Cystic Renal Cell Carcinoma|Multilocular Clear Cell Renal Cell Carcinoma|Renal Cystadenocarcinoma	A rare type of renal cell carcinoma.  It is a well-circumscribed multicystic mass without solid areas.  The inner lining of the cystic structures is composed of clear cells -- 2003
C4525	Renal_Sarcoma	Malignant_Renal_Neoplasm|Soft_Tissue_Sarcoma	Renal Sarcoma|Kidney Sarcoma|Sarcoma of Kidney|Sarcoma of the Kidney
C4526	Renal_Oncocytoma	Benign_Renal_Neoplasm|Oncocytic_Neoplasm	Renal Oncocytoma|Kidney Oncocytoma|Oncocytoma of Kidney|Oncocytoma of the Kidney|Renal Epithelial Oncocytic Neoplasm|Renal Epithelial Oncocytic Tumor	A benign tumor of the kidney, characterized by the presence of large cells with abundant eosinophilic granular cytoplasm.  The majority of these tumors are discovered incidentally, during work-up of other conditions. (NCI05)
C4527	Kidney_Hemangiopericytoma	Hemangiopericytoma|Renal_Neoplasm	Renal Hemangiopericytoma|Hemangiopericytoma of Kidney|Hemangiopericytoma of the Kidney|Kidney Hemangiopericytoma
C4528	Renal_Pelvis_Papilloma	Benign_Renal_Pelvis_Neoplasm|Renal_Pelvis_Papillary_Neoplasm|Urothelial_Papilloma	Renal Pelvis Urothelial Papilloma
C4529	Stage_0is_Ureter_Cancer	Stage_0_Ureter_Cancer|Stage_0is_Renal_Pelvis_and_Ureter_Carcinoma|Ureter_Transitional_Cell_Carcinoma	Stage 0is Ureter Cancer|Carcinoma in situ of Ureter|Carcinoma in situ of the Ureter|Stage 0is Carcinoma of Ureter|Stage 0is Carcinoma of the Ureter|Stage 0is Ureter Carcinoma|Stage 0is Ureteral Carcinoma|Ureter Cancer Stage 0is|Ureter Carcinoma in situ|Ureteral Carcinoma in situ
C4530	Ureter_Polyp	Benign_Ureter_Neoplasm|Polyp	Ureter Polyp|Polyp of Ureter|Polyp of the Ureter|Ureteral Polyp
C4531	Stage_0is_Urethral_Cancer	Carcinoma_in_situ|Stage_0_Urethral_Cancer	Stage 0is Urethral Cancer|Carcinoma in situ of Urethra|Carcinoma in situ of the Urethra|Stage 0is Carcinoma of Urethra|Stage 0is Carcinoma of the Urethra|Stage 0is Urethra Carcinoma|Stage 0is Urethral Carcinoma|Urethra Carcinoma in situ|Urethral Carcinoma in situ
C4532	Benign_Paraurethral_Gland_Neoplasm	Benign_Urethral_Neoplasm|Paraurethral_Gland_Neoplasm	Benign Paraurethral Gland Neoplasm|Benign Neoplasm of Paraurethral Gland|Benign Neoplasm of the Paraurethral Gland|Benign Paraurethral Gland Tumor|Benign Tumor of Paraurethral Gland|Benign Tumor of the Paraurethral Gland
C4533	Malignant_Choroid_Plexus_Neoplasm	Choroid_Plexus_Neoplasm|Malignant_Brain_Neoplasm	Malignant Choroid Plexus Neoplasm|Malignant Choroid Plexus Neoplasms|Malignant Choroid Plexus Tumor|Malignant Choroid Plexus Tumors|Malignant Neoplasm of Choroid Plexus|Malignant Neoplasm of the Choroid Plexus|Malignant Tumor of Choroid Plexus|Malignant Tumor of the Choroid Plexus
C4534	Spinal_Cord_Glial_Neoplasm	Neuroglial_Tumor|Spinal_Cord_Neoplasm	Spinal Cord Glial Neoplasm|Glial Neoplasm Spinal Cord|Glial Tumor of Spinal Cord|Spinal Cord Glial Neoplasms|Spinal Cord Glial Tumor|Spinal Cord Glial Tumors	Benign and malignant neoplasms that arise from glial cells of the spinal cord.  Subtypes include ependymoma, astrocytoma (including low and high grade forms), medulloblastoma, and oligodendroglioma. (KEV 8-22-99)
C4535	Spinal_Cord_Oligodendroglioma	Oligodendroglioma|Spinal_Cord_Glial_Neoplasm	Spinal Cord Oligodendroglioma|Oligodendroglioma of Spinal Cord|Well Differentiated Spinal Cord Oligodendroglial Tumor|Well Differentiated Spinal Cord Oligodendroglioma
C4536	Pituitary_Gland_Carcinoma	Adenocarcinoma|Anterior_Pituitary_Gland_Neoplasm|Infrequent_Neoplasm|Malignant_Endocrine_Neoplasm|Malignant_Pituitary_Gland_Neoplasm	Pituitary Gland Carcinoma|Cancer of Pituitary|Cancer of Pituitary Gland|Cancer of the Pituitary|Cancer of the Pituitary Gland|Carcinoma of Pituitary|Carcinoma of Pituitary Gland|Carcinoma of the Pituitary|Carcinoma of the Pituitary Gland|Pituitary Carcinoma|Pituitary Gland Adenocarcinoma|Pituitary Gland Cancer	A rare adenocarcinoma with poor prognosis, arising from the adenohypophysial cells of the anterior lobe of the pituitary gland or pre-existing adenomas.  The majority are hormonally functioning neoplasms, usually producing prolactin or ACTH.  The diagnosis is based on the presence of metastases.  Syndromes associated with pituitary gland carcinomas include hyperprolactinemia, Cushing disease, and acromegaly. (NCI05)
C4537	Optic_Nerve_Glioma	Optic_Nerve_Neoplasm|Visual_Pathway_Glioma	Optic Nerve Glioma|Glioma of Optic Nerve|Glioma of the Optic Nerve	Abnormal growth of cells that comprise the optic tract. This condition can be seen in association with Neurofibromatosis 1. It is most commonly seen in the pediatric age group.
C4538	Optic_Nerve_Sheath_Meningioma	Visual_Pathway_Meningioma	Optic Nerve Sheath Meningioma|Meningioma of Optic Nerve Sheath|Meningioma of the Optic Nerve Sheath
C4539	Malignant_Vestibulocochlear_Nerve_Neoplasm	Malignant_Cranial_Nerve_Neoplasm	Malignant Vestibulocochlear Nerve Neoplasm|Cancer of Vestibulocochlear Nerve|Cancer of the Vestibulocochlear Nerve|Malignant Acoustic Nerve Neoplasm|Malignant Acoustic Nerve Tumor|Malignant Eighth Cranial Nerve Neoplasm|Malignant Eighth Cranial Nerve Tumor|Malignant Neoplasm of Acoustic Nerve|Malignant Neoplasm of Eighth Cranial Nerve|Malignant Neoplasm of Vestibulocochlear Nerve|Malignant Neoplasm of the Acoustic Nerve|Malignant Neoplasm of the Eighth Cranial Nerve|Malignant Neoplasm of the Vestibulocochlear Nerve|Malignant Tumor of Acoustic Nerve|Malignant Tumor of Eighth Cranial Nerve|Malignant Tumor of Vestibulocochlear Nerve|Malignant Tumor of the Acoustic Nerve|Malignant Tumor of the Eighth Cranial Nerve|Malignant Tumor of the Vestibulocochlear Nerve|Malignant Vestibulocochlear Nerve Tumor	Abnormal malignant growth of the cells that comprise cranial nerve VIII. This can lead to difficulties with hearing and balance.
C4540	Lacrimal_Gland_Adenoid_Cystic_Carcinoma	Adenoid_Cystic_Carcinoma|Lacrimal_Gland_Carcinoma	Lacrimal Gland Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Lacrimal Gland|Adenoid Cystic Carcinoma of the Lacrimal Gland
C4541	Lacrimal_Gland_Adenocarcinoma	Adenocarcinoma|Lacrimal_Gland_Carcinoma	Lacrimal Gland Adenocarcinoma|Adenocarcinoma of Lacrimal Gland|Adenocarcinoma of the Lacrimal Gland
C4542	Lacrimal_Gland_Pleomorphic_Adenoma	Benign_Lacrimal_Gland_Neoplasm|Pleomorphic_Adenoma	Lacrimal Gland Pleomorphic Adenoma|Benign Mixed Tumor of Lacrimal Gland|Benign Mixed Tumor of the Lacrimal Gland|Lacrimal Gland Benign Mixed Tumor|Pleomorphic Adenoma of Lacrimal Gland|Pleomorphic Adenoma of the Lacrimal Gland	A benign, usually encapsulated neoplasm of the lacrimal gland composed of epithelial and mesenchymal cells.  Pleomorphic adenomas are neoplasms that develop in the salivary glands or heterotopic salivary gland tissues.  It has been suggested that myoepithelial cells play a major role in the histogenesis of these tumors.  In the lacrimal gland, pleomorphic adenomas presumably develop from metaplastic myoepithelial cells. --2003
C4543	Orbit_Rhabdomyosarcoma	Orbit_Sarcoma|Rhabdomyosarcoma	Orbit Rhabdomyosarcoma|Rhabdomyosarcoma of Orbit|Rhabdomyosarcoma of the Orbit
C4544	Malignant_Orbit_Hemangiopericytoma	Malignant_Hemangiopericytoma|Malignant_Orbit_Neoplasm|Orbit_Hemangiopericytoma	Malignant Orbit Hemangiopericytoma|Malignant Hemangiopericytoma of Orbit|Malignant Hemangiopericytoma of the Orbit|Malignant Orbital Hemangiopericytoma
C4545	Orbit_Capillary_Hemangioma	Capillary_Hemangioma|Orbit_Hemangioma	Orbit Capillary Hemangioma|Capillary Angioma of Orbit|Capillary Angioma of the Orbit|Capillary Hemangioma of Orbit|Capillary Hemangioma of the Orbit|Orbit Capillary Angioma
C4546	Orbit_Cavernous_Hemangioma	Cavernous_Hemangioma|Orbit_Hemangioma	Orbit Cavernous Hemangioma|Cavernous Angioma of Orbit|Cavernous Angioma of the Orbit|Cavernous Hemangioma of Orbit|Cavernous Hemangioma of the Orbit|Orbit Cavernous Angioma
C4547	Orbit_Hemangiopericytoma	Hemangiopericytoma	Orbit Hemangiopericytoma|Hemangiopericytoma of Orbit|Hemangiopericytoma of the Orbit|Orbital Hemangiopericytoma
C4548	Orbit_Dermoid_Cyst	Benign_Orbit_Neoplasm|Dermoid_Cyst	Orbit Dermoid Cyst|Dermoid Cyst of Orbit|Dermoid Cyst of the Orbit
C4549	Conjunctival_Squamous_Cell_Carcinoma	Malignant_Conjunctival_Neoplasm|Squamous_Cell_Carcinoma	Conjunctival Squamous Cell Carcinoma|Conjunctiva Epidermoid Carcinoma|Conjunctiva Squamous Cell Carcinoma|Conjunctival Epidermoid Carcinoma|Epidermoid Carcinoma of Conjunctiva|Epidermoid Carcinoma of the Conjunctiva|Squamous Cell Carcinoma of Conjunctiva|Squamous Cell Carcinoma of the Conjunctiva
C4550	Conjunctival_Melanoma	Ocular_Melanoma	Conjunctival Melanoma|Conjunctiva Melanoma|Malignant Conjunctiva Melanoma|Malignant Conjunctival Melanoma|Malignant Melanoma of Conjunctiva|Malignant Melanoma of the Conjunctiva|Melanoma of Conjunctiva|Melanoma of the Conjunctiva	A malignant melanoma within the conjunctiva of the eye.
C4551	Conjunctival_Nevus	Benign_Conjunctival_Neoplasm|Benign_Melanocytic_Nevus	Conjunctival Nevus|Nevus of Conjunctiva|Nevus of the Conjunctiva
C4552	Corneal_Squamous_Cell_Carcinoma	Malignant_Corneal_Neoplasm|Squamous_Cell_Carcinoma	Corneal Squamous Cell Carcinoma|Cornea Epidermoid Carcinoma|Cornea Squamous Cell Carcinoma|Corneal Epidermoid Carcinoma|Epidermoid Carcinoma of Cornea|Epidermoid Carcinoma of the Cornea|Squamous Cell Carcinoma of Cornea|Squamous Cell Carcinoma of the Cornea
C4553	Corneal_Melanoma	Ocular_Melanoma	Corneal Melanoma|Cornea Melanoma|Malignant Cornea Melanoma|Malignant Corneal Melanoma|Malignant Melanoma of Cornea|Malignant Melanoma of the Cornea|Melanoma of Cornea|Melanoma of the Cornea	A melanoma within the cornea of the eye.
C4554	Malignant_Iris_Neoplasm	Iris_Neoplasm|Malignant_Uveal_Neoplasm	Malignant Iris Neoplasm|Malignant Iris Tumor|Malignant Neoplasm of Iris|Malignant Neoplasm of the Iris|Malignant Tumor of Iris|Malignant Tumor of the Iris
C4555	Benign_Iris_Neoplasm	Benign_Uveal_Neoplasm|Iris_Neoplasm	Benign Iris Neoplasm|Benign Iris Tumor|Benign Neoplasm of Iris|Benign Neoplasm of the Iris|Benign Tumor of Iris|Benign Tumor of the Iris
C4556	Iris_Nevus	Benign_Iris_Neoplasm	Iris Nevus|Nevus of Iris|Nevus of the Iris
C4557	Ciliary_Body_Medulloepithelioma	Malignant_Ciliary_Body_Neoplasm|Medulloepithelioma	Ciliary Body Medulloepithelioma|Medulloepithelioma of Ciliary Body|Medulloepithelioma of the Ciliary Body
C4558	Ciliary_Body_Melanoma	Malignant_Ciliary_Body_Neoplasm|Uveal_Melanoma	Ciliary Body Melanoma|Ciliary Body Malignant Melanoma|Malignant Melanoma of Ciliary Body|Malignant Melanoma of the Ciliary Body|Melanoma of Ciliary Body|Melanoma of the Ciliary Body
C4559	Ciliary_Body_Fuchs_Adenoma	Adenoma|Benign_Ciliary_Body_Neoplasm	Ciliary Body Fuchs' Adenoma|Fuchs' Adenoma of Ciliary Body|Fuchs' Adenoma of the Ciliary Body
C4560	Ciliary_Body_Leiomyoma	Benign_Ciliary_Body_Neoplasm|Leiomyoma	Ciliary Body Leiomyoma|Leiomyoma of Ciliary Body|Leiomyoma of the Ciliary Body
C4561	Choroid_Melanoma	Malignant_Choroid_Neoplasm|Uveal_Melanoma	Choroid Melanoma|Choroid Malignant Melanoma|Malignant Melanoma of Choroid|Malignant Melanoma of the Choroid|Melanoma of Choroid|Melanoma of the Choroid
C4562	Choroid_Hemangioma	Benign_Choroid_Neoplasm|Hemangioma	Choroid Hemangioma|Angioma of Choroid|Angioma of the Choroid|Benign Angioma of Choroid|Benign Angioma of the Choroid|Benign Choroid Angioma|Benign Choroid Hemangioma|Benign Hemangioma of Choroid|Benign Hemangioma of the Choroid|Choroid Angioma|Hemangioma of Choroid|Hemangioma of the Choroid|Hemangioma, Choroid, Benign
C4563	Chronic_Eosinophilic_Leukemia	Chronic_Leukemia|Chronic_Myeloproliferative_Disorder	Chronic Eosinophilic Leukemia|Eosinophilic Leukemia	A rare chronic myeloproliferative disorder characterized by a clonal proliferation of eosinophilic precursors resulting in persistently increased numbers of eosinophils in the blood, marrow and peripheral tissues.  Since acute eosinophilic leukemia is at best exceedingly rare, the term eosinophilic leukemia is normally used as a synonym for chronic eosinophilic leukemia.  In cases in which it is impossible to prove clonality and there is no increase in blast cells, the diagnosis of "idiopathic hypereosinophilic syndrome" is preferred.  (WHO, 2001) -- 2003
C4564	Splenic_Angiosarcoma	Angiosarcoma|Malignant_Splenic_Soft_Tissue_Tumor	Splenic Angiosarcoma|Angiosarcoma of Spleen|Angiosarcoma of the Spleen|Hemangiosarcoma of Spleen|Hemangiosarcoma of the Spleen|Splenic Hemangiosarcoma
C4565	Benign_Thoracic_Neoplasm	Thoracic_Neoplasm	Benign Thoracic Neoplasm|Benign Neoplasm of Thorax|Benign Neoplasm of the Thorax|Benign Thoracic Tumor|Benign Tumor of Thorax|Benign Tumor of the Thorax
C4566	Malignant_Lung_Hilum_Neoplasm	Lung_Hilum_Neoplasm|Malignant_Lung_Neoplasm	Malignant Lung Hilum Neoplasm|Malignant Hilar Lung Neoplasm|Malignant Hilar Lung Tumor|Malignant Lung Hilum Tumor|Malignant Neoplasm of Lung Hilum|Malignant Neoplasm of the Lung Hilum|Malignant Tumor of Lung Hilum|Malignant Tumor of the Lung Hilum
C4567	Malignant_Pericardial_Neoplasm	Malignant_Cardiac_Neoplasm|Pericardial_Neoplasm	Malignant Pericardial Neoplasm|Malignant Neoplasm of Pericardium|Malignant Neoplasm of the Pericardium|Malignant Pericardial Tumor|Malignant Tumor of Pericardium|Malignant Tumor of the Pericardium
C4568	Malignant_Epicardial_Neoplasm	Epicardial_Neoplasm|Malignant_Cardiac_Neoplasm	Malignant Epicardial Neoplasm|Malignant Epicardial Tumor|Malignant Neoplasm of Epicardium|Malignant Neoplasm of the Epicardium|Malignant Tumor of Epicardium|Malignant Tumor of the Epicardium
C4569	Malignant_Myocardial_Neoplasm	Malignant_Cardiac_Neoplasm|Myocardial_Neoplasm	Malignant Myocardial Neoplasm|Malignant Myocardial Tumor|Malignant Neoplasm of Myocardium|Malignant Neoplasm of the Myocardium|Malignant Tumor of Myocardium|Malignant Tumor of the Myocardium
C4570	Malignant_Endocardial_Neoplasm	Endocardial_Neoplasm|Malignant_Cardiac_Neoplasm	Malignant Endocardial Neoplasm|Malignant Endocardial Tumor|Malignant Neoplasm of Endocardium|Malignant Neoplasm of the Endocardium|Malignant Tumor of Endocardium|Malignant Tumor of the Endocardium
C4571	Malignant_Respiratory_Tract_Neoplasm	Respiratory_Tract_Neoplasm	Malignant Respiratory Tract Neoplasm|Malignant Neoplasm of Respiratory Tract|Malignant Neoplasm of the Respiratory Tract|Malignant Respiratory Tract Tumor|Malignant Tumor of Respiratory Tract|Malignant Tumor of the Respiratory Tract	Malignant neoplasms originating in the respiratory tract
C4572	Malignant_Intestinal_Neoplasm	Intestinal_Neoplasm|Malignant_Gastrointestinal_Neoplasm	Malignant Intestinal Neoplasm|Bowel Cancer|Cancer of Intestine|Cancer of the Intestine|Intestinal Cancer|Intestinal Neoplasms, Malignant|Intestinal Tumors, Malignant|Malignant Intestinal Neoplasms|Malignant Intestinal Tumor|Malignant Intestinal Tumors|Malignant Intestine Neoplasm|Malignant Intestine Tumor|Malignant Neoplasm of Intestine|Malignant Neoplasm of the Intestine|Malignant Tumor of Intestine|Malignant Tumor of the Intestine	A primary or metastatic malignant tumor involving the small intestine, large intestine, or both.  Representative examples are carcinomas, lymphomas, and sarcomas. -- 2004
C4573	Malignant_Skin_Appendage_Neoplasm	Skin_Appendage_Neoplasm	Malignant Skin Appendage Neoplasm|Malignant Cutaneous Adnexal Neoplasm|Malignant Epidermal Appendage Neoplasm|Malignant Epidermal Appendage Tumor|Malignant Neoplasm of Epidermal Appendage|Malignant Neoplasm of the Epidermal Appendage|Malignant Skin Adnexal Neoplasm|Malignant Skin Adnexal Tumor|Malignant Tumor of Epidermal Appendage|Malignant Tumor of the Epidermal Appendage
C4574	Malignant_Dermal_Neoplasm	Dermal_Neoplasm	Malignant Dermal Neoplasm|Malignant Dermis Neoplasm|Malignant Dermis Tumor|Malignant Neoplasm of Dermis|Malignant Neoplasm of the Dermis|Malignant Tumor of Dermis|Malignant Tumor of the Dermis
C4575	Malignant_Great_Vessel_Neoplasm	Great_Vessel_Neoplasm	Malignant Great Vessel Neoplasm|Great Vessel Cancer|Malignant Great Vessel Tumor
C4576	Malignant_Thalamic_Neoplasm	Malignant_Diencephalic_Neoplasm|Thalamic_Neoplasm	Malignant Thalamic Neoplasm|Malignant Neoplasm of Thalamus|Malignant Neoplasm of the Thalamus|Malignant Thalamic Neoplasms|Malignant Thalamic Tumor|Malignant Thalamic Tumors|Malignant Thalamus Neoplasm|Malignant Thalamus Neoplasms|Malignant Thalamus Tumor|Malignant Thalamus Tumors|Malignant Tumor of Thalamus|Malignant Tumor of the Thalamus
C4577	Malignant_Cerebral_Neoplasm	Cerebral_Neoplasm|Malignant_Supratentorial_Neoplasm	Malignant Cerebral Neoplasm|Cerebral Cancer|Malignant Cerebral Hemispheric Neoplasm|Malignant Cerebral Hemispheric Tumor|Malignant Cerebral Tumor|Malignant Neoplasm of Cerebral Hemispheres|Malignant Neoplasm of Cerebrum|Malignant Neoplasm of the Cerebral Hemispheres|Malignant Neoplasm of the Cerebrum|Malignant Tumor of Cerebral Hemispheres|Malignant Tumor of Cerebrum|Malignant Tumor of the Cerebral Hemispheres|Malignant Tumor of the Cerebrum
C4578	Conjunctival_Kaposi_s_Sarcoma	Kaposi_s_Sarcoma|Malignant_Conjunctival_Neoplasm	Conjunctival Kaposi's Sarcoma|Kaposi's Sarcoma of Conjunctiva|Kaposi's Sarcoma of the Conjunctiva
C4579	Corneal_Kaposi_s_Sarcoma	Kaposi_s_Sarcoma|Malignant_Corneal_Neoplasm	Corneal Kaposi's Sarcoma|Kaposi's Sarcoma of Cornea|Kaposi's Sarcoma of the Cornea
C4580	Malignant_Chest_Wall_Neoplasm	Chest_Wall_Neoplasm|Malignant_Thoracic_Neoplasm	Malignant Chest Wall Neoplasm|Malignant Chest Wall Tumor|Malignant Neoplasm of Chest Wall|Malignant Neoplasm of the Chest Wall|Malignant Tumor of Chest Wall|Malignant Tumor of the Chest Wall
C4581	Metastatic_Neoplasm_to_the_Large_Intestine	Malignant_Colorectal_Neoplasm|Metastatic_Neoplasm_to_the_Abdominal_Cavity	Metastatic Malignant Neoplasm to the Large Intestine|Metastases to Large Intestine|Metastasis to Large Bowel|Metastasis to the Large Bowel|Metastasis to the Large Intestine|Metastatic Neoplasm to the Large Intestine|Metastatic Tumor to the Large Intestine	The spread of cancer to the large intestine.  This may be from a primary colon cancer, or from a cancer at a distant site.
C4582	Metastatic_Neoplasm_to_the_Bone_Marrow	Malignant_Bone_Marrow_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Bone Marrow|Metastases to the Bone Marrow|Metastasis to the Bone Marrow|Metastatic Neoplasm to the Bone Marrow|Metastatic Tumor to the Bone Marrow|bone marrow metastases	Cancer that has spread from the original (primary) tumor to the bone marrow.
C4583	Metastatic_Neoplasm_to_the_Peritoneum	Malignant_Peritoneal_Neoplasm|Metastatic_Neoplasm_to_the_Abdominal_Cavity	Metastatic Malignant Neoplasm to the Peritoneum|Metastasis to the Peritoneum|Metastatic Neoplasm to the Peritoneum
C4584	Metastatic_Neoplasm_to_the_Testis	Malignant_Testicular_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Testis|Metastatic Neoplasm to the Testis|Metastatic Tumor to the Testis
C4585	Metastasis_to_Spinal_Cord	Malignant_Spinal_Cord_Neoplasm|Metastatic_Neoplasm_to_the_Central_Nervous_System	Metastatic Malignant Neoplasm to the Spinal Cord|Metastasis to Spinal Cord|Metastatic Neoplasm to the Spinal Cord|Metastatic Tumor to the Spinal Cord|Secondary Malignant Neoplasm to the Spinal Cord|Secondary Malignant Tumor to the Spinal Cord
C4586	Metastatic_Neoplasm_to_the_Eye	Malignant_Eye_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Eye|Eye Metastasis|Metastases to Eye|Metastases to the Eye|Metastasis to Eye|Metastasis to the Eye|Metastatic Neoplasm to the Eye|Metastatic Tumor to the Eye
C4587	Stage_0_Oral_Cavity_Carcinoma	Carcinoma_in_situ|Oral_Cavity_Carcinoma	Stage 0 Oral Cavity Carcinoma|Carcinoma in situ of Mouth|Carcinoma in situ of Oral Cavity|Carcinoma in situ of the Mouth|Carcinoma in situ of the Oral Cavity|Mouth Carcinoma in situ|Oral Cavity Carcinoma in situ|Stage 0 Carcinoma of Mouth|Stage 0 Carcinoma of Oral Cavity|Stage 0 Carcinoma of the Mouth|Stage 0 Carcinoma of the Oral Cavity|Stage 0 Mouth Carcinoma
C4588	Stage_0_Lip_Cancer	Lip_Carcinoma	Stage 0 Lip Cancer|Carcinoma in situ of Lip|Carcinoma in situ of the Lip|Lip Carcinoma in situ|Stage 0 Cancer of Lip|Stage 0 Cancer of the Lip|Stage 0 Carcinoma of Lip|Stage 0 Carcinoma of the Lip|Stage 0 Lip Carcinoma
C4589	Stage_0_Nasal_Cavity_Carcinoma	Nasal_Cavity_Carcinoma	Stage 0 Nasal Cavity Carcinoma|Carcinoma in situ of Nasal Cavity|Carcinoma in situ of the Nasal Cavity|Nasal Cavity Carcinoma in situ|Stage 0 Carcinoma of Nasal Cavity|Stage 0 Carcinoma of the Nasal Cavity
C4590	Stage_0_Oropharyngeal_Carcinoma	Oropharyngeal_Carcinoma	Stage 0 Oropharyngeal Carcinoma|Carcinoma in situ of Oropharynx|Carcinoma in situ of the Oropharynx|Oropharyngeal Cancer Stage 0|Oropharyngeal Carcinoma in situ|Oropharynx Carcinoma in situ|Stage 0 Carcinoma of Oropharynx|Stage 0 Carcinoma of the Oropharynx|Stage 0 Oropharyngeal Cancer|Stage 0 Oropharynx Carcinoma	Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C4591	Carcinoma_in_situ_of_the_Hypopharynx	Stage_0_Hypopharyngeal_Cancer	Carcinoma In Situ of the Hypopharynx|Carcinoma in situ of Hypopharynx|Hypopharyngeal Carcinoma in situ
C4592	Stage_0_Epiglottic_Carcinoma	Epiglottic_Carcinoma|Stage_0_Squamous_Cell_Carcinoma	Stage 0 Epiglottic Carcinoma|Carcinoma in situ of Epiglottis|Carcinoma in situ of the Epiglottis|Epiglottic Carcinoma in situ|Epiglottis Carcinoma in situ
C4593	Stage_0_Appendix_Carcinoma	Appendix_Carcinoma|Gastrointestinal_Carcinoma_in_situ	Stage 0 Appendix Carcinoma|Carcinoma in situ of Appendix|Carcinoma in situ of the Appendix|Stage 0 Appendix Cancer
C4594	Cecum_Carcinoma_in_situ	Cecum_Carcinoma|Stage_0_Colon_Cancer	Cecum Carcinoma In Situ|Carcinoma in situ of Cecum|Carcinoma in situ of the Cecum|Stage 0 Cecum Carcinoma
C4595	Anal_Intraepithelial_Neoplasia	Anal_Neoplasm|Anal_Precancerous_Condition|Gastrointestinal_Intraepithelial_Neoplasia	Anal Intraepithelial Neoplasia|AIN|Intraepithelial Neoplasia of Anus|Intraepithelial Neoplasia of the Anus
C4596	Penile_Intraepithelial_Neoplasia	Male_Reproductive_System_Precancerous_Condition|Penile_Neoplasm|Squamous_Cell_Intraepithelial_Neoplasia	Penile Intraepithelial Neoplasia
C4597	Stage_0is_Renal_Pelvis_Carcinoma	Renal_Pelvis_Transitional_Cell_Carcinoma|Stage_0_Renal_Pelvis_Carcinoma|Stage_0is_Renal_Pelvis_and_Ureter_Carcinoma	Stage 0is Renal Pelvis Carcinoma|Carcinoma in situ of Kidney Pelvis|Carcinoma in situ of Renal Pelvis|Carcinoma in situ of the Kidney Pelvis|Carcinoma in situ of the Renal Pelvis|Kidney Pelvis Carcinoma in situ|Renal Pelvis Carcinoma in situ|Stage 0is Carcinoma of Kidney Pelvis|Stage 0is Carcinoma of Renal Pelvis|Stage 0is Carcinoma of the Kidney Pelvis|Stage 0is Carcinoma of the Renal Pelvis|Stage 0is Kidney Pelvis Carcinoma
C4598	Benign_Gingival_Neoplasm	Benign_Oral_Cavity_Neoplasm|Gingival_Neoplasm	Benign Gingival Neoplasm|Benign Gingival Tumor|Benign Gum Neoplasm|Benign Gum Tumor|Benign Neoplasm of Gingiva|Benign Neoplasm of Gum|Benign Neoplasm of the Gingiva|Benign Neoplasm of the Gum|Benign Tumor of Gingiva|Benign Tumor of Gum|Benign Tumor of the Gingiva|Benign Tumor of the Gum
C4599	Benign_Palate_Neoplasm	Palate_Neoplasm	Benign Palate Neoplasm|Benign Neoplasm of Palate|Benign Neoplasm of the Palate|Benign Palate Tumor|Benign Tumor of Palate|Benign Tumor of the Palate
C4600	Benign_Salivary_Gland_Neoplasm	Salivary_Gland_Neoplasm	Benign Salivary Gland Neoplasm|Benign Neoplasm of Salivary Gland|Benign Neoplasm of the Salivary Gland|Benign Salivary Gland Tumor|Benign Tumor of Salivary Gland|Benign Tumor of the Salivary Gland|Salivary Gland Neoplasm, Benign
C4601	Benign_Sublingual_Gland_Neoplasm	Benign_Major_Salivary_Gland_Neoplasm|Sublingual_Gland_Neoplasm	Benign Sublingual Gland Neoplasm|Benign Neoplasm of Sublingual Gland|Benign Neoplasm of the Sublingual Gland|Benign Sublingual Gland Tumor|Benign Tumor of Sublingual Gland|Benign Tumor of the Sublingual Gland
C4602	Benign_Middle_Ear_Neoplasm	Benign_Ear_Neoplasm|Middle_Ear_Neoplasm	Benign Middle Ear Neoplasm|Benign Middle Ear Tumor|Benign Neoplasm of Middle Ear|Benign Neoplasm of the Middle Ear|Benign Tumor of Middle Ear|Benign Tumor of the Middle Ear
C4603	Benign_Nasal_Cavity_Neoplasm	Nasal_Cavity_Neoplasm	Benign Nasal Cavity Neoplasm|Benign Nasal Cavity Tumor|Benign Neoplasm of Nasal Cavity|Benign Neoplasm of the Nasal Cavity|Benign Tumor of Nasal Cavity|Benign Tumor of the Nasal Cavity
C4604	Benign_Oropharyngeal_Neoplasm	Benign_Pharyngeal_Neoplasm|Oropharyngeal_Neoplasm	Benign Oropharyngeal Neoplasm|Benign Neoplasm of Oropharynx|Benign Neoplasm of the Oropharynx|Benign Oropharyngeal Tumor|Benign Tumor of Oropharynx|Benign Tumor of the Oropharynx|Oropharyngeal Neoplasm Benign
C4605	Benign_Glottis_Neoplasm	Benign_Laryngeal_Neoplasm|Glottis_Neoplasm	Benign Glottis Neoplasm|Benign Glottis Tumor|Benign Neoplasm of Glottis|Benign Neoplasm of the Glottis|Benign Tumor of Glottis|Benign Tumor of the Glottis
C4606	Benign_Epiglottis_Neoplasm	Benign_Supraglottis_Neoplasm|Epiglottis_Neoplasm	Benign Epiglottis Neoplasm|Benign Epiglottic Neoplasm|Benign Epiglottic Tumor|Benign Epiglottis Tumor|Benign Neoplasm of Epiglottis|Benign Neoplasm of the Epiglottis|Benign Tumor of Epiglottis|Benign Tumor of the Epiglottis
C4607	Benign_Myocardial_Neoplasm	Benign_Cardiac_Neoplasm|Myocardial_Neoplasm	Benign Myocardial Neoplasm|Benign Myocardial Tumor|Benign Neoplasm of Myocardium|Benign Neoplasm of the Myocardium|Benign Tumor of Myocardium|Benign Tumor of the Myocardium
C4608	Benign_Endocardial_Neoplasm	Benign_Cardiac_Neoplasm|Endocardial_Neoplasm	Benign Endocardial Neoplasm|Benign Endocardial Tumor|Benign Neoplasm of Endocardium|Benign Neoplasm of the Endocardium|Benign Tumor of Endocardium|Benign Tumor of the Endocardium
C4609	Benign_Intestinal_Neoplasm	Benign_Gastrointestinal_Neoplasm|Intestinal_Neoplasm	Benign Intestinal Neoplasm|Benign Intestinal Neoplasms|Benign Intestinal Tumor|Benign Intestinal Tumors|Benign Intestine Neoplasm|Benign Intestine Tumor|Benign Neoplasm of Intestines|Benign Neoplasm of the Intestines|Benign Neoplasms of Large and/or Small Intestine|Benign Neoplasms of the Large and/or Small Intestine|Benign Tumor of Intestines|Benign Tumor of the Intestines|Intestinal Neoplasms, Benign|Intestinal Tumors, Benign
C4610	Benign_Colorectal_Neoplasm	Benign_Intestinal_Neoplasm|Colorectal_Neoplasm	Benign Colorectal Neoplasm|Benign Colorectal Neoplasms|Benign Colorectal Tumor|Benign Colorectal Tumors|Benign Large Bowel Neoplasm|Benign Large Bowel Tumor|Benign Large Intestine Neoplasm|Benign Large Intestine Tumor|Benign Neoplasm of Large Bowel|Benign Neoplasm of Large Intestine|Benign Neoplasm of the Large Bowel|Benign Neoplasm of the Large Intestine|Benign Tumor of Large Bowel|Benign Tumor of Large Intestine|Benign Tumor of the Large Bowel|Benign Tumor of the Large Intestine|Colorectal Neoplasms, Benign|Colorectal Tumors, Benign|Neoplasms, Colorectal, Benign|Tumors, Colorectal, Benign	A benign tumor arising from the wall of the colon and rectum. -- 2003
C4611	Benign_Anal_Neoplasm	Anal_Neoplasm|Benign_Gastrointestinal_Neoplasm	Benign Anal Neoplasm|Benign Anal Tumor|Benign Neoplasm of Anus|Benign Neoplasm of the Anus|Benign Tumor of Anus|Benign Tumor of the Anus
C4612	Benign_Pancreatic_Neoplasm	Pancreatic_Neoplasm	Benign Pancreatic Neoplasm|Benign Neoplasm of Pancreas|Benign Neoplasm of the Pancreas|Benign Pancreas Neoplasm|Benign Pancreas Tumor|Benign Pancreatic Neoplasm NOS|Benign Pancreatic Tumor|Benign Tumor of Pancreas|Benign Tumor of the Pancreas|Pancreas Neoplasm, Benign|Pancreas Tumor, Benign|Pancreatic Neoplasm, Benign|Pancreatic Tumor, Benign	Abnormal growth, without malignant characteristics, of the cells that comprise the pancreas.
C4613	Benign_Exocrine_Pancreatic_Neoplasm	Benign_Pancreatic_Neoplasm|Exocrine_Pancreas_Neoplasm	Benign Exocrine Pancreas Neoplasm|Benign Exocrine Pancreas Tumor|Benign Exocrine Pancreatic Neoplasm|Benign Neoplasm of Exocrine Pancreas|Benign Neoplasm of the Exocrine Pancreas|Benign Tumor of Exocrine Pancreas|Benign Tumor of the Exocrine Pancreas
C4614	Skin_Papilloma	Benign_Epithelial_Skin_Neoplasm|Papilloma	Skin Papilloma|Cutaneous Papilloma|Papilloma of Skin|Papilloma of the Skin	small pendulous outgrowth of the skin; in middle life, it usually occurs on the neck in pedunculated seborrheic keratosis.
C4615	Benign_Skin_Appendage_Neoplasm	Benign_Skin_Neoplasm|Skin_Appendage_Neoplasm	Benign Skin Appendage Neoplasm|Benign Cutaneous Adnexal Neoplasm|Benign Epidermal Appendage Neoplasm|Benign Epidermal Appendage Tumor|Benign Neoplasm of Epidermal Appendage|Benign Neoplasm of the Epidermal Appendage|Benign Tumor of Epidermal Appendage|Benign Tumor of the Epidermal Appendage
C4616	Cutaneous_Lipoma	Benign_Dermal_Neoplasm|Common_Connective_and_Soft_Tissue_Neoplasm|Cutaneous_Lipomatous_Neoplasm|Lipoma	Cutaneous Lipoma|Lipoma of Skin|Lipoma of the Skin|Skin Lipoma
C4618	External_Ear_Lipoma	Benign_External_Ear_Neoplasm|Lipoma	External Ear Lipoma|External Auditory Meatus Lipoma|Lipoma of External Auditory Meatus|Lipoma of External Ear|Lipoma of the External Auditory Meatus|Lipoma of the External Ear
C4619	Spinal_Cord_Lipoma	Benign_Spinal_Cord_Neoplasm|Central_Nervous_System_Lipoma	Spinal Cord Lipoma|Lipoma of Spinal Cord
C4620	Benign_Male_Breast_Neoplasm	Benign_Breast_Neoplasm	Benign Male Breast Neoplasm|Benign Male Breast Tumor|Benign Neoplasm of Male Breast|Benign Neoplasm of the Male Breast|Benign Tumor of Male Breast|Benign Tumor of the Male Breast
C4621	Benign_Endocrine_Neoplasm	Endocrine_Neoplasm	Benign Endocrine Neoplasm|Benign Endocrine Gland Neoplasm|Benign Endocrine Gland Tumor|Benign Endocrine Tumor|Benign Neoplasm of Endocrine Gland|Benign Neoplasm of the Endocrine Gland|Benign Tumor of Endocrine Gland|Benign Tumor of the Endocrine Gland	A benign growth of hormone secreting tissue.
C4622	Meningeal_Cyst	Central_Nervous_System_Cyst	Meningeal Cyst|Cyst of Meninges|Cyst of the Meninges|Meninges Cyst
C4623	Malignant_Jugulotympanic_Paraganglioma	Jugulotympanic_Paraganglioma|Malignant_Extra-Adrenal_Paraganglioma	Malignant Jugulotympanic Paraganglioma|Malignant Glomus Jugulare Neoplasm|Malignant Glomus Jugulare Tumor|Malignant Neoplasm of Glomus Jugulare|Malignant Neoplasm of the Glomus Jugulare|Malignant Tumor of Glomus Jugulare|Malignant Tumor of the Glomus Jugulare	A jugulotympanic paraganglioma that metastasizes to other anatomic sites.
C4624	Malignant_Coccygeal_Body_Neoplasm	Coccygeal_Body_Neoplasm|Malignant_Bone_Neoplasm	Malignant Coccygeal Body Neoplasm|Malignant Coccygeal Body Tumor|Malignant Glomus Coccygeum Neoplasm|Malignant Glomus Coccygeum Tumor|Malignant Neoplasm of Coccygeal Body|Malignant Neoplasm of the Coccygeal Body|Malignant Tumor of Coccygeal Body|Malignant Tumor of the Coccygeal Body
C4627	Malignant_Central_Nervous_System_Neoplasm	Central_Nervous_System_Neoplasm|Malignant_Nervous_System_Neoplasm	Malignant Central Nervous System Neoplasm|CNS Cancer|CNS Malignant Neoplasms|CNS Neoplasms, Malignant|Cancer of CNS|Cancer of Central Nervous System|Cancer of the CNS|Cancer of the Central Nervous System|Central Nervous System Cancer|Central Nervous System Neoplasms, Malignant|Malignant CNS Neoplasm|Malignant CNS Neoplasms|Malignant CNS Tumor|Malignant Central Nervous System Tumor|Malignant Neoplasm of CNS|Malignant Neoplasm of Central Nervous System|Malignant Neoplasm of the CNS|Malignant Neoplasm of the Central Nervous System|Malignant Tumor of CNS|Malignant Tumor of Central Nervous System|Malignant Tumor of the CNS|Malignant Tumor of the Central Nervous System
C4628	Malignant_Neoplasms_of_the_Meninges	Malignant_Central_Nervous_System_Neoplasm|Meningeal_Neoplasm	Malignant Neoplasm of the Meninges|Cancer of Meninges|Cancer of the Meninges|Malignant Meningeal Neoplasms|Malignant Meningeal Tumor|Malignant Meninges Neoplasm|Malignant Meninges Tumor|Malignant Neoplasm of Meninges|Malignant Neoplasms of Meninges|Malignant Tumor of Meninges|Malignant Tumor of the Meninges|Meningeal Cancer|Meningeal Tumors, Malignant	A primary or metastatic malignant tumor occurring in the meninges, which surround the brain and spinal cord.  The most common are meningiomas. - 2004
C4630	Low-Grade_Cervical_Intraepithelial_Neoplasia	Cervical_Intraepithelial_Neoplasia|Low_Grade_Intraepithelial_Neoplasia	Low Grade Cervical Intraepithelial Neoplasia|Low-Grade Cervix Intraepithelial Neoplasia|Low-Grade Cervix Uteri Intraepithelial Neoplasia|Low-Grade Intraepithelial Neoplasia of Cervix|Low-Grade Intraepithelial Neoplasia of Cervix Uteri|Low-Grade Intraepithelial Neoplasia of Uterine Cervix|Low-Grade Intraepithelial Neoplasia of the Cervix|Low-Grade Intraepithelial Neoplasia of the Cervix Uteri|Low-Grade Intraepithelial Neoplasia of the Uterine Cervix|Low-Grade Uterine Cervix Intraepithelial Neoplasia
C4631	Grade_II_Cervical_Intraepithelial_Neoplasia	Retired_Concepts	Grade II Cervical Intraepithelial Neoplasia|CIN 2|CIN Grade 2|CIN II|Cervical Intraepithelial Neoplasia Grade 2|Cervix Intraepithelial Neoplasia Grade 2|Cervix Uteri Intraepithelial Neoplasia Grade 2|Intraepithelial Neoplasia of Cervix Grade 2|Intraepithelial Neoplasia of Cervix Uteri Grade 2|Intraepithelial Neoplasia of Uterine Cervix Grade 2|Intraepithelial Neoplasia of the Cervix Grade 2|Intraepithelial Neoplasia of the Cervix Uteri Grade 2|Intraepithelial Neoplasia of the Uterine Cervix Grade 2|Moderate Cervical Dysplasia|Moderate Cervix Dysplasia|Moderate Cervix Uteri Dysplasia|Moderate Dysplasia of Cervix|Moderate Dysplasia of Cervix Uteri|Moderate Dysplasia of Uterine Cervix|Moderate Dysplasia of the Cervix|Moderate Dysplasia of the Cervix Uteri|Moderate Dysplasia of the Uterine Cervix|Moderate Uterine Cervix Dysplasia|Uterine Cervix Intraepithelial Neoplasia Grade 2
C4632	Dermoid_Cyst_of_the_Skin	Benign_Skin_Neoplasm|Dermoid_Cyst	Dermoid Cyst of the Skin|Cutaneous Dermoid Cyst|Cystic Skin Teratoma|Dermoid Cyst of Skin|Skin Dermoid|Skin Dermoid Cyst
C4633	Amelanotic_Skin_Melanoma	Amelanotic_Melanoma|Cutaneous_Melanoma	Amelanotic Skin Melanoma|Amelanotic Malignant Melanoma (of Skin)|Amelanotic Malignant Melanoma of Skin|Amelanotic Malignant Melanoma of the Skin|Amelanotic Malignant Skin Melanoma|Amelanotic Melanoma of Skin|Amelanotic Melanoma of the Skin
C4634	Cutaneous_Fibrous_Tissue_Neoplasm	Dermal_Neoplasm	Cutaneous Fibrous Tissue Neoplasm|Cutaneous Fibrocytic Neoplasm|Cutaneous Fibrocytic Tumor|Cutaneous Fibrous Tissue Tumor|Skin Fibrous Tissue Neoplasm|Skin Fibrous Tissue Tumor
C4635	Gastric_Carcinoid_Tumor	Foregut_Carcinoid_Tumor|Gastric_Neuroendocrine_Neoplasm|Gastrointestinal_Carcinoid_Tumor	Gastric Carcinoid Tumor|Carcinoid Neoplasm of Stomach|Carcinoid Neoplasm of the Stomach|Carcinoid Tumor of Stomach|Carcinoid Tumor of the Stomach|Gastric Carcinoid Neoplasm|Stomach Carcinoid Neoplasm|Stomach Carcinoid Tumor|Well-Differentiated Gastric Neuroendocrine Neoplasm|Well-Differentiated Gastric Neuroendocrine Tumor|Well-Differentiated Neuroendocrine Neoplasm of Stomach|Well-Differentiated Neuroendocrine Neoplasm of the Stomach|Well-Differentiated Neuroendocrine Tumor of Stomach|Well-Differentiated Neuroendocrine Tumor of the Stomach	A neuroendocrine tumor of the stomach, occurs most often in elderly females.  It may arise in a background of atrophic gastritis, usually resulting from pernicious anemia.  Gastric carcinoid tumors can be solitary or multiple, sometimes arise in individuals with the MEN-1 syndrome, and rarely metastasize.  (WHO, 2000) -- 2003
C4636	Gastric_Lymphoma	Gastrointestinal_Lymphoma|Malignant_Gastric_Neoplasm	Gastric Lymphoma|Lymphoma of Stomach|Lymphoma of the Stomach|Primary Gastric Lymphoma	A lymphoma originating from the stomach and contiguous lymph nodes.  The majority are high-grade B-cell non-Hodgkin's lymphomas, some of which have developed through progression from low-grade lymphomas of mucosa-associated lymphoid tissue.  Primary gastric lymphomas are often associated with Helicobacter Pylori infection.  (WHO, 2000) -- 2003
C4637	Intestinal_Carcinoid_Tumor	Gastrointestinal_Carcinoid_Tumor|Intestinal_Neuroendocrine_Neoplasm	Intestinal Carcinoid Tumor|Carcinoid Neoplasm of Intestine|Carcinoid Neoplasm of the Intestine|Carcinoid Tumor of Intestine|Carcinoid Tumor of the Intestine|Intestinal Carcinoid Neoplasm|Intestine Carcinoid Neoplasm|Intestine Carcinoid Tumor
C4638	Small_Intestinal_Carcinoid_Tumor	Intestinal_Carcinoid_Tumor|Small_Intestinal_Neuroendocrine_Neoplasm	Small Intestinal Carcinoid Tumor|Carcinoid Neoplasm of Small Bowel|Carcinoid Neoplasm of Small Intestine|Carcinoid Neoplasm of the Small Bowel|Carcinoid Neoplasm of the Small Intestine|Carcinoid Tumor of Small Bowel|Carcinoid Tumor of Small Intestine|Carcinoid Tumor of the Small Bowel|Carcinoid Tumor of the Small Intestine|Small Bowel Carcinoid Neoplasm|Small Bowel Carcinoid Tumor|Small Intestine Carcinoid Neoplasm|Small Intestine Carcinoid Tumor
C4639	Anal_Melanoma	Gastrointestinal_Melanoma|Malignant_Anal_Neoplasm	Anal Melanoma|Anal Malignant Melanoma|Malignant Melanoma of Anus|Malignant Melanoma of the Anus|Melanoma of Anus|Melanoma of the Anus
C4640	Rectal_Melanoma	Gastrointestinal_Melanoma|Malignant_Rectal_Neoplasm|Non-Cutaneous_Melanoma	Rectal Melanoma|Malignant Melanoma of Rectum|Malignant Melanoma of the Rectum|Melanoma of Rectum|Melanoma of the Rectum|Rectal Malignant Melanoma
C4641	Spinal_Cord_Astrocytoma	Astrocytic_Tumor|Spinal_Cord_Glial_Neoplasm	Spinal Cord Astrocytoma|Astrocytic Neoplasm of Spinal Cord|Astrocytic Neoplasm of the Spinal Cord|Astrocytic Tumor of Spinal Cord|Astrocytic Tumor of the Spinal Cord|Astrocytoma of Spinal Cord|Astrocytoma of the Spinal Cord|Spinal Astrocytic Tumor|Spinal Astrocytoma|Spinal Cord Astrocytic Neoplasm|Spinal Cord Astrocytic Tumor	Low and high grade astrocytomas which arise in the spinal cord.  Histologic types include pilocytic astrocytomas, fibrillary astrocytomas, anaplastic astrocytomas and glioblastoma multiforme.  (From Schutta, Spinal Tumors, in Clinical Neurology, Ch44, p42, 1994)
C4642	Brain_Glioblastoma	Glioblastoma	Brain Glioblastoma|Brain Glioblastoma Multiforme|Glioblastoma Multiforme of Brain|Glioblastoma Multiforme of the Brain|Grade IV Astrocytic Neoplasm of Brain|Grade IV Astrocytic Neoplasm of the Brain|Grade IV Astrocytic Tumor of Brain|Grade IV Astrocytic Tumor of the Brain|Grade IV Astrocytoma of Brain|Grade IV Astrocytoma of the Brain|Grade IV Brain Astrocytic Neoplasm|Grade IV Brain Astrocytic Tumor|Grade IV Brain Astrocytoma
C4643	Scrotal_Squamous_Cell_Carcinoma	Scrotal_Carcinoma|Squamous_Cell_Carcinoma	Scrotal Squamous Cell Carcinoma|Squamous Cell Carcinoma of Scrotum|Squamous Cell Carcinoma of the Scrotum
C4644	Low_Grade_Vaginal_Intraepithelial_Neoplasia	Low_Grade_Squamous_Intraepithelial_Neoplasia|Vaginal_Intraepithelial_Neoplasia	Low Grade Vaginal Intraepithelial Neoplasia|Grade 1 Vaginal Intraepithelial Neoplasia|Grade I Vaginal Intraepithelial Neoplasia|Intraepithelial Neoplasia of Vagina Grade 1|Intraepithelial Neoplasia of the Vagina Grade 1|Low Grade VAIN|VAIN 1|VAIN Grade 1|Vaginal Intraepithelial Neoplasia Grade 1
C4645	Grade_II_Vaginal_Intraepithelial_Neoplasia	High_Grade_Vaginal_Intraepithelial_Neoplasia	Grade 2 Vaginal Intraepithelial Neoplasia|Grade 2 VAIN|Grade II Vaginal Intraepithelial Neoplasia|Intraepithelial Neoplasia of Vagina Grade 2|Intraepithelial Neoplasia of the Vagina Grade 2|VAIN 2|VAIN II|Vaginal Intraepithelial Neoplasia Grade 2
C4646	Gestational_Choriocarcinoma	Choriocarcinoma|Common_Germ_Cell_Neoplasm|Gestational_Trophoblastic_Tumor	Gestational Choriocarcinoma	A rare, highly malignant, epithelial tumor that develops from a hydatidiform mole (50%), following abortion (25%), or during normal pregnancy (22%). Histologically, choriocarcinomas consist of invasive and anaplastic trophoblastic tissue composed of cytotrophoblastic and syncytiotrophoblastic cells, secretion of human chorionic gonadotropin, and abundant vascularity. Because of rapid growth and a high propensity for hemorrhage, this neoplasm often constitutes a medical emergency. --2004
C4647	Breast_Lipoma	Benign_Breast_Neoplasm|Breast_Soft_Tissue_Neoplasm|Common_Connective_and_Soft_Tissue_Neoplasm|Lipoma	Breast Lipoma|Lipoma of Breast|Lipoma of the Breast	Benign fatty tumor involving the breast.
C4648	Tongue_Squamous_Cell_Carcinoma	Oral_Cavity_Squamous_Cell_Carcinoma|Tongue_Carcinoma	Tongue Squamous Cell Carcinoma|SCC of Tongue|SCC of the Tongue|Squamous Cell Carcinoma of Tongue|Squamous Cell Carcinoma of the Tongue|Tongue SCC
C4649	Palate_Squamous_Cell_Carcinoma	Oral_Cavity_Squamous_Cell_Carcinoma|Palate_Carcinoma	Palate Squamous Cell Carcinoma|Palate SCC|SCC of Palate|SCC of the Palate|Squamous Cell Carcinoma of Palate|Squamous Cell Carcinoma of the Palate
C4650	Parotid_Gland_Pleomorphic_Adenoma	Benign_Parotid_Gland_Neoplasm|Mixed_Tumor_of_the_Parotid_Gland|Salivary_Gland_Pleomorphic_Adenoma	Parotid Gland Pleomorphic Adenoma|Benign Mixed Tumor of Parotid Gland|Benign Mixed Tumor of the Parotid Gland|Parotid Gland Benign Mixed Tumor|Parotid Pleomorphic Adenoma|Pleomorphic Adenoma of Parotid|Pleomorphic Adenoma of Parotid Gland|Pleomorphic Adenoma of the Parotid|Pleomorphic Adenoma of the Parotid Gland
C4651	Pericardial_Neoplasm	Cardiac_Neoplasm	Pericardial Neoplasm|Neoplasm of Pericardium|Neoplasm of the Pericardium|Pericardial Tumor|Tumor of Pericardium|Tumor of the Pericardium
C4652	External_Ear_Neoplasm	Ear_Neoplasm|External_Ear_Disorder	External Ear Neoplasm|External Ear Tumor|Neoplasm of External Ear|Neoplasm of the External Ear|Tumor of External Ear|Tumor of the External Ear
C4653	Malignant_External_Ear_Neoplasm	External_Ear_Neoplasm|Malignant_Ear_Neoplasm	Malignant External Ear Neoplasm|Malignant External Ear Tumor|Malignant Neoplasm of External Ear|Malignant Neoplasm of the External Ear|Malignant Tumor of External Ear|Malignant Tumor of the External Ear
C4654	Atypical_Endometrial_Hyperplasia	Atypical_Glandular_Hyperplasia|Endometrial_Hyperplasia|Female_Reproductive_System_Precancerous_Condition	Atypical Endometrial Hyperplasia|Atypical Hyperplasia of Endometrium|Atypical Hyperplasia of the Endometrium|Endometrial Hyperplasia with Atypia	An Endometrial Hyperplasia characterized by cytologic and architectural changes which may lead to Endometrial Carcinoma.  Despite the atypical features and possible course, there is debate on whether to consider this a neoplasm.  The relationship with Endometrial Intraepithelial Neoplasia is also unclear.
C4655	Trigeminal_Schwannoma	Schwannoma|Trigeminal_Nerve_Neoplasm	Trigeminal Schwannoma|Fifth Cranial Nerve Neurilemmoma|Fifth Cranial Nerve Schwannoma|Neurilemmoma of Fifth Cranial Nerve|Neurilemmoma of Trigeminal Nerve|Neurilemmoma of the Fifth Cranial Nerve|Neurilemmoma of the Trigeminal Nerve|Schwannoma of Fifth Cranial Nerve|Schwannoma of Trigeminal Nerve|Schwannoma of the Fifth Cranial Nerve|Schwannoma of the Trigeminal Nerve|Trigeminal Neurilemmoma
C4656	Intracranial_Meningioma	Intracranial_Neoplasm|Meningioma_by_Site	Intracranial Meningioma
C4657	Central_Nervous_System_Cyst	Cyst|Nervous_System_Finding	Central Nervous System Cyst|CNS Cyst|Cyst of CNS|Cyst of Central Nervous System|Cyst of the CNS|Cyst of the Central Nervous System
C4658	Epidermoid_Intraspinal_Cyst	Central_Nervous_System_Epidermoid_Cyst|Intraspinal_Cyst	Epidermoid Intraspinal Cyst|Epidermoid Spinal Cyst
C4659	Pineal_Region_Germ_Cell_Tumor	Central_Nervous_System_Germ_Cell_Neoplasm|Pineal_Region_Neoplasm	Pineal Region Germ Cell Tumor|Pineal Area Germ Cell Neoplasm|Pineal Area Germ Cell Tumor|Pineal Germ Cell Neoplasm|Pineal Germ Cell Tumor|Pineal Region Germ Cell Neoplasm
C4660	Meningeal_Hemangiopericytoma	Hemangiopericytoma_of_the_Central_Nervous_System|Meningeal_Neoplasm	Meningeal Hemangiopericytoma|Hemangiopericytoma of Meninges|Hemangiopericytoma of the Meninges|Meninges Hemangiopericytoma
C4661	Primary_Melanocytic_Lesion_of_Meninges	Central_Nervous_System_Melanocytic_Neoplasm|Meningeal_Neoplasm	Primary Melanocytic Lesion of Meninges|CNS Primary Melanocytic Lesions|Central Nervous System Primary Melanocytic Lesions|Primary Melanocytic Lesions of CNS|Primary Melanocytic Lesions of Central Nervous System|Primary Melanocytic Lesions of the CNS|Primary Melanocytic Lesions of the Central Nervous System	Primary Melanocytic Lesions are diffuse or circumscribed, benign or malignant tumors arising from melanocytes of the leptomeninges. This group includes: (1) Diffuse Melanocytosis (diffuse melanosis) and Neurocutaneous Melanosis, (2) Melanocytoma, and (3) Malignant Melanoma, but intermediate or mixed cases may occur.  (Adapted from WHO.)
C4662	Meningeal_Melanocytoma	Benign_Neoplasms_of_the_Meninges|Melanocytoma|Primary_Melanocytic_Lesion_of_Meninges	Meningeal Melanocytoma|Leptomeningeal Melanocytoma|Melanocytoma of Meninges|Melanocytoma of the Meninges|Meninges Melanocytoma
C4663	Splenic_Marginal_Zone_Lymphoma	Marginal_Zone_B-Cell_Lymphoma|Splenic_Non-Hodgkin_s_Lymphoma	Splenic Marginal Zone B-Cell Lymphoma|Marginal Zone Lymphoma of Spleen|Marginal Zone Lymphoma of the Spleen|SMZL|Splenic Lymphoma with Circulating Villous Lymphocytes|Splenic Marginal Zone Lymphoma	A B-cell non-Hodgkin's lymphoma composed of small lymphocytes which surround and replace the splenic white pulp germinal centers.  This entity was previously known as a splenic lymphoma with circulating villous lymphocytes, is rare, and involves the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood.  The patients present with splenomegaly and the clinical course is indolent.  (WHO, 2001) -- 2003
C4664	T-Cell_Large_Granular_Lymphocyte_Leukemia	Chronic_Leukemia|Lymphoid_Leukemia|Mature_T-Cell_and_NK-Cell_Neoplasm	T-Cell Large Granular Lymphocyte Leukemia|Chronic T-Cell Leukemia|Chronic T-Cell Lymphocytic Leukemia|LGLL|Large Cell Granular Lymphogenous Leukemia|Large Cell Granular Lymphoid Leukemia|Large Granular Lymphocytic Leukemia|Large Granular Lymphocytosis|T Cell CLL|T Cell Chronic Lymphocytic Leukemia|T Gamma Lymphoproliferative Disorder|T-Cell CLL|T-Cell Chronic Lymphocytic Leukemia|T-Cell Chronic Lymphogenous Leukemia|T-Cell Chronic Lymphoid Leukemia|T-Cell Large Granular Lymphocytic Leukemia|T-Gamma Lymphoproliferative Disorder|Tgamma Large Granular Lymphocyte Leukemia	A T-cell peripheral neoplasm characterized by a persistent (>6 months) increase in the number of peripheral blood large granular lymphocytes, without a clearly identified cause. (WHO, 2001) -- 2003
C4665	Plasma_Cell_Neoplasm	Mature_B-Cell_Lymphocytic_Neoplasm	Plasma Cell Neoplasm|Plasma Cell Dyscrasia|Plasma Cell Tumor|Plasmacytic Neoplasm|Plasmacytic Tumor|Plasmacytic Tumour	A malignant (clonal) proliferation of immunoglobulin secreting plasma cells.  Plasma cells are of B cell origin, and are grouped under Mature B-Cell Neoplasm in the WHO classification.  (WHO, 2001) -- 2003
C4666	Spindle_Cell_Sarcomatoid_Squamous_Cell_Skin_Carcinoma	Sarcomatoid_Squamous_Cell_Carcinoma|Skin_Squamous_Cell_Carcinoma	Spindle Cell (Sarcomatoid) Squamous Cell Skin Carcinoma|Spindle Cell Squamous Carcinoma of Skin|Spindle Cell Squamous Carcinoma of the Skin
C4668	Immature_Mediastinal_Teratoma	Immature_Extragonadal_Teratoma|Malignant_Mediastinal_Germ_Cell_Neoplasm|Mediastinal_Teratoma	Mediastinal Immature Teratoma|Immature Mediastinal Teratoma|Immature Teratoma of Mediastinum|Immature Teratoma of the Mediastinum|Malignant Mediastinal Teratoma|Malignant Teratoma of Mediastinum|Malignant Teratoma of the Mediastinum
C4669	Bladder_Sarcoma	Malignant_Bladder_Neoplasm|Soft_Tissue_Sarcoma	Bladder Sarcoma|Sarcoma of Bladder|Sarcoma of Urinary Bladder|Sarcoma of the Bladder|Sarcoma of the Urinary Bladder|Urinary Bladder Sarcoma
C4670	Breast_Sarcoma	Breast_Soft_Tissue_Neoplasm|Malignant_Breast_Neoplasm|Soft_Tissue_Sarcoma	Breast Sarcoma|Sarcoma of Breast|Sarcoma of the Breast
C4671	Breast_Lymphoma	Lymphoma_by_Site|Malignant_Breast_Neoplasm	Breast Lymphoma|Lymphoma of Breast|Lymphoma of the Breast|Primary Breast Lymphoma
C4672	Testicular_Sertoli_Cell_Tumor	Sertoli_Cell_Tumor|Testicular_Sex_Cord-Stromal_Tumor	Testicular Sertoli Cell Tumor|Sertoli Cell Neoplasm of Testis|Sertoli Cell Neoplasm of the Testis|Sertoli Cell Tumor of Testis|Sertoli Cell Tumor of the Testis|Testicular Androblastoma|Testicular Sertoli Cell Neoplasm
C4673	Acute_Biphenotypic_Leukemia	Acute_Leukemia_of_Ambiguous_Lineage	Acute Biphenotypic Leukemia	An acute leukemia of ambiguous lineage characterized by blasts which coexpress myeloid and T or B lineage antigens or concurrent B and T lineage antigens.  (WHO, 2001) -- 2003
C4674	Verrucous_Nevus	Non-Neoplastic_Nevus	Verrucous Nevus|Verrucous Epidermal Nevus
C4675	Congenital_Epulis	Non-Neoplastic_Oral_Cavity_Disorder	Congenital Epulis
C4676	Skull_Base_Neoplasm	Intracranial_Neoplasm|Skull_Neoplasm	Skull Base Neoplasm|Neoplasm of Skull Base|Neoplasm of the Skull Base|Neoplasms of Skull Base|Neoplasms of the Skull Base|Skull Base Neoplasms|Skull Base Tumor|Skull Base Tumors|Tumor of Skull Base|Tumor of the Skull Base|Tumors of Skull Base|Tumors of the Skull Base
C4678	Organoid_Nevus	Benign_Sebaceous_Neoplasm	Organoid Nevus|Linear Sebaceous Nevus|Nevus Sebaceous of Jadassohn
C4679	Laryngeal_Keratosis	Laryngeal_Precancerous_Condition|Leukoplakia	Laryngeal Keratosis|Keratosis of Larynx|Keratosis of the Larynx|Laryngeal Leukoplakia
C4680	Plantar_Fibromatosis	Benign_Cutaneous_Fibrous_Neoplasm|Superficial_Fibromatosis	Plantar Fibromatosis|Ledderhose's Disease
C4681	Hypomelia_Hypotrichosis_Facial_Hemangioma_Syndrome	Hereditary_Neoplastic_Syndrome	Hypomelia Hypotrichosis Facial Hemangioma Syndrome|Phocomelia-Pseudothalidomide Syndrome|Pseudothalidomide Syndrome|Roberts-SC Phocomelia Syndrome
C4682	X-Linked_Severe_Combined_Immunodeficiency	Severe_Combined_Immunodeficiency	X-Linked Severe Combined Immunodeficiency	Rare congenital disorder inherited as an X-linked defect characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels.
C4683	Dermatofibrosarcoma_Protuberans	Intermediate_Cutaneous_Fibrohistiocytic_Neoplasm|Sarcoma_NCI_Grade_1	Dermatofibrosarcoma Protuberans|DFSP|Dermatofibrosarcoma|dermatofibrosarcoma protuberans	(DER-ma-toe-FI-bro-sar-KO-ma pro-TOO-ber-anz) A type of tumor that begins as a hard nodule and grows slowly.  These tumors are usually found in the dermis (the inner layer of the two main layers of tissue that make up the skin) of the limbs or trunk of the body.  They can grow into surrounding tissue but do not spread to other parts of the body.
C4684	Nasal_Type_Extranodal_NK_T-Cell_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Nasal Type Extranodal NK/T-Cell Lymphoma|Angiocentric T-Cell Lymphoma	An aggressive, predominantly extranodal, mature T-cell non-Hodgkin's lymphoma.  It is characterized by an often angiocentric and angiodestructive cellular infiltrate composed of EBV positive NK/T cells.  The nasal cavity is the commonest site of involvement.  Patients often present with midfacial destructive lesions (lethal midline granuloma).  The disease may disseminate rapidly to various anatomic sites including gastrointestinal tract, skin, testis, and cervical lymph nodes.  It is also known as angiocentric T-cell lymphoma.  The term "polymorphic reticulosis" has been widely used to describe the morphologic changes seen in this type of lymphoma.  However, the latter term may also apply to lymphomatoid granulomatosis which is an angiocentric and angiodestructive EBV positive B-cell lymphoproliferative disorder.  -- 2003
C4685	Paraneoplastic_Cerebellar_Degeneration	Paraneoplastic_Syndrome	Paraneoplastic Cerebellar Degeneration
C4686	Opsoclonus_Myoclonus_Syndrome	Paraneoplastic_Syndrome	Opsoclonus Myoclonus Syndrome	A combination of opsoclonus (involuntary conjugate eye movements of large amplitude) and myoclonic jerks. This can be a paraneoplastic syndrome (a result of brain metastasis) or post-infectious (viral encephalitis).
C4687	Tactile_Epilepsy	Epilepsy	Tactile Epilepsy
C4688	Paget_s_Disease_of_the_Skin	Retired_Concepts	Paget's Disease of the Skin|Cutaneous Paget's Disease|Paget's Disease of Skin|Paget's Skin Disease
C4689	Leukocyte_Adhesion_Deficiency_Type_1	Non-Neoplastic_Hematologic_Disorder	Leukocyte Adhesion Deficiency Type 1|LAD-Type I|LFA-I Deficiency	Leukocyte Adhesion Deficiency, Type I; LFA-I deficiency
C4690	Leukocyte_Adhesion_Deficiency_Type_2	Non-Neoplastic_Hematologic_Disorder	Leukocyte Adhesion Deficiency Type 2|LAD-Type II|Sialyl-Lewis X Defect	Leukocyte Adhesion Deficiency, Type II.  An inherited disease affecting the metabolism of fucose, which affects the expression of the sialyl Lewis X antigen, the fucose-containing ligand for E- and P-selectins, resulting in a deficiency in neutrophil adhesion.  SYN Sialyl-Lewis X defect.
C4691	Complement_Deficiency	Immunodeficiency_Syndrome	Complement Deficiency
C4692	Nijmegen_Breakage_Syndrome	DNA_Repair_Disorder	Nijmegen Breakage Syndrome	A disorder, wherein unstable chromosomes have a tendency to break and become rearranged, characterized by microcephaly, stunted growth, subnormal mental development, cafe-au-lait spots, and immunodeficiency. The syndrome is named after the University of Nijmegen in the Netherlands. (JABL99)
C4693	Gingival_Fibroepithelial_Polyp	Fibroepithelial_Polyp|Gingival_Polyp	Gingival Fibroepithelial Polyp|Fibroepithelial Polyp of Gingiva|Fibroepithelial Polyp of Gum|Fibroepithelial Polyp of the Gingiva|Fibroepithelial Polyp of the Gum|Gum Fibroepithelial Polyp
C4694	Ulcerated_Oral_Leukoplakia	Oral_Leukoplakia	Ulcerated Oral Leukoplakia
C4695	Speckled_Oral_Leukoplakia	Oral_Leukoplakia	Speckled Oral Leukoplakia
C4696	Verrucous_Oral_Leukoplakia	Oral_Leukoplakia	Verrucous Oral Leukoplakia|Papillary Leukoplakia
C4697	Smokers_Keratosis	Laryngeal_Keratosis	Smokers Keratosis
C4698	Dry_Orgasm	Sexual_Dysfunction	Dry Orgasm|Retrograde Ejaculation|dry orgasm	Sexual climax without the release of semen from the penis.
C4699	Gestational_Trophoblastic_Tumor	Female_Reproductive_System_Neoplasm|Trophoblastic_Neoplasm	Gestational Trophoblastic Tumor|GTT|Gestational Trophoblastic Neoplasm|gestational trophoblastic disease|gestational trophoblastic neoplasia|gestational trophoblastic tumor	A rare cancer in women of childbearing age in which cancer cells grow in the tissues that are formed in the uterus after conception.
C4700	Giant_Cell_Fibroblastoma	Intermediate_Cutaneous_Fibrohistiocytic_Neoplasm	Giant Cell Fibroblastoma	An intermediate cutaneous fibrohistiocytic neoplasm typically affecting young patients (predominantly boys), characterized by painless nodules in the dermis or subcutaneous tissues.  This tumor can recur, but metastases have not been reported. -- 2003
C4701	Encephalocraniocutaneous_Lipomatosis	Lipomatosis	Encephalocraniocutaneous Lipomatosis|ECCL|Fishman Syndrome
C4702	Palmoplantar_Keratoderma_with_Leukoplakia	Diffuse_Palmoplantar_Keratoderma	Palmoplantar Keratoderma with Leukoplakia
C4703	Eccrine_Angiomatous_Hamartoma	Eccrine_Sweat_Gland_Hamartoma	Eccrine Angiomatous Hamartoma|Angiomatous Hamartoma, Eccrine|Eccrine Angiomatous Nevus
C4704	Moniliform_Hamartoma	Pilosebaceous_Hamartoma	Moniliform Hamartoma|Hamartoma Moniliformis
C4705	Carney_Complex	Hereditary_Neoplastic_Syndrome	Carney Syndrome|Atrial Myxoma with Lentigines|Carney Complex|Carney's Syndrome|LAMB|Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome|NAME|Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome
C4706	Circumscribed_Storiform_Collagenoma	Collagen_Nevus	Circumscribed Storiform Collagenoma
C4707	Eruptive_Collagenoma	Collagen_Nevus	Eruptive Collagenoma
C4708	Limbal_Metaplasia	Metaplasia	Limbal Metaplasia
C4709	Interaretynoid_Leukoplakia	Leukoplakia_of_Vocal_Cords	Interaretynoid Leukoplakia
C4710	Left_Ventricular_Ejection_Fraction	Retired_Concepts	Left Ventricular Ejection Fraction
C4711	Borderline_Cystadenoma	Cystadenoma|Neoplasm_of_Uncertain_Malignant_Potential	Borderline Cystadenoma
C4712	Adenocarcinoma_with_Metaplasia	Adenocarcinoma	Adenocarcinoma with Metaplasia
C4713	Cellular_Ependymoma	Ependymoma	Cellular Ependymoma	Cellular Ependymoma is a variant of Ependymoma which shows conspicuous cellularity without a significant increase in mitotic rate. (Adapted from WHO)
C4714	Clear_Cell_Ependymoma	Ependymoma	Clear Cell Ependymoma	An ependymoma, often supratentorial in location, characterized by the presence of ependymal cells with a perinuclear halo.
C4715	Choroid_Plexus_Carcinoma	Carcinoma|Malignant_Choroid_Plexus_Neoplasm	Choroid Plexus Carcinoma|Cancer of Choroid Plexus|Cancer of the Choroid Plexus|Carcinoma of Choroid Plexus|Carcinoma of the Choroid Plexus|Choroid Plexus Cancer	Choroid Plexus Carcinoma (WHO grade III) is a malignant Choroid Plexus Tumor which shows anaplastic features and usually invades neighboring brain structures. CSF metastases are frequent. (Adapted from WHO.)
C4716	Rhabdomyosarcoma_with_Ganglionic_Differentiation	Rhabdomyosarcoma	Rhabdomyosarcoma with Ganglionic Differentiation|Ectomesenchymoma
C4717	Anaplastic_Ganglioglioma	Neuronal_and_Mixed_Neuronal-Glial_Tumor	Anaplastic Ganglioglioma	Anaplastic Ganglioglioma (WHO grade III) is a neuroepithelial neoplasm composed of neoplastic, mature ganglion cells and anaplastic glial cells. These anaplastic changes in the glial component and high MIB-1 and TP53 labelling indices may indicate aggressive behavior.  However, the correlation of histological anaplasia with clinical outcome is inconsistent. (Adapted from WHO.)
C4718	Secretory_Meningioma	Grade_I_Meningioma	Secretory Meningioma	A WHO grade I meningioma characterized by the presence of pseudo-psammoma bodies: focal epithelial differentiation, in the form of intracellular lumina containing PAS-positive, eosinophilic material. (Adapted from WHO 2000.) - 2004
C4719	Choroid_Plexus_Meningioma	Intracranial_Meningioma	Choroid Plexus Meningioma|Meningioma of Choroid Plexus|Meningioma of the Choroid Plexus
C4720	Lymphoplasmacyte-Rich_Meningioma	Grade_I_Meningioma	Lymphoplasmacyte-Rich Meningioma	A WHO grade I meningioma characterized by extensive chronic inflammatory infiltrates with the meningothelial component in the background. (Adapted from WHO 2000.) - 2004
C4721	Microcystic_Meningioma	Grade_I_Meningioma	Microcystic Meningioma	A WHO grade I meningioma characterized by cells with elongated processes and by a loose, mucinous background, giving the appearance of many small cysts. There may be many pleomorphic cells. (Adapted from WHO 2000.) - 2004
C4722	Clear_Cell_Meningioma	Grade_II_Meningioma	Clear Cell Meningioma	A WHO grade II morphologic variant of meningioma characterized by the presence of clear glycogen-rich polygonal cells.
C4723	Atypical_Meningioma	Grade_II_Meningioma	Atypical Meningioma	A WHO grade II meningioma with increased mitotic activity or three or more of the following features: increased cellularity, small cells with high nuclear to cytoplasm ratio, prominent nucleoli, uninterrupted patternless or sheet-like growth, and foci of spontaneous or geographic necrosis. (Adapted from WHO 2000.) - 2004
C4724	Cellular_Schwannoma	Schwannoma	Cellular Schwannoma|Cellular Neurilemmoma|Cellular Neurinoma	Cellular Schwannoma (also called Cellular Neurilemmoma or Cellular Neurinoma) is a hypercellular Schwannoma composed exclusively or predominantly of Antoni A tissue, and devoid of Verocay bodies. Cellular Schwannomas are benign, although recurrences can occur, especially when located in the spine. (Adapted from WHO.)
C4725	Papillary_Craniopharyngioma	Craniopharyngioma	Papillary Craniopharyngioma|Papillary Neoplasm of Rathke's Pouch|Papillary Rathke's Pouch Neoplasm|Papillary Rathke's Pouch Tumor|Papillary Tumor of Rathke's Pouch	Papillary Craniopharyngioma is composed of sheets of squamous epithelium which separate to form pseudopapillae. This variant typically lacks nuclear palisading, wet keratin, calcification, and cholesterol deposits. Clinically, endocrine deficiencies are more often associated with Papillary Craniopharyngioma than with the Adamantinomatous type. (Adapted from WHO.)
C4726	Adamantinous_Craniopharyngioma	Craniopharyngioma	Adamantinous Craniopharyngioma|Adamantinomatous Craniopharyngioma|Adamantinous Neoplasm of Rathke's Pouch|Adamantinous Rathke's Pouch Neoplasm|Adamantinous Rathke's Pouch Tumor|Adamantinous Tumor of Rathke's Pouch	Adamantinomatous Craniopharyngioma consists of broad strands, cords and bridges of a multistratified squamous epithelium with peripheral palisading of nuclei. Diagnostic features include nodules of compact 'wet' keratin and dystrophic calcification. (Adapted from WHO.)
C4727	Post-Transplant_Lymphoproliferative_Disorder	Lymphoproliferative_Disorder|Transplant-Related_Disorder	Post-Transplant Lymphoproliferative Disorder|PTLD|Posttransplantation Lymphoproliferative Disorders	Post-transplant lymphoproliferative disorder (PTLD) is a polyclonal (benign) or clonal (malignant) proliferation of lymphoid cells that develops as a consequence of immunosuppression in a recipient of a solid organ or bone marrow allograft.  PTLDs comprise a spectrum ranging from early, Epstein-Barr virus (EBV)-driven polyclonal lymphoid proliferations to EBV-positive or EBV- negative lymphomas of predominantly B-cell or less often T-cell type. (WHO, 2001) -- 2003
C4728	Proliferative_Fasciitis	Benign_Fibrous_Soft_Tissue_Neoplasm	Proliferative Fasciitis
C4729	Intravascular_Nodular_Fasciitis	Nodular_Fasciitis	Intravascular Nodular Fasciitis|Intravascular Fasciitis|Intravascular Pseudosarcomatous Fasciitis
C4730	Atypical_Lobular_Breast_Hyperplasia	Atypical_Hyperplasia_of_the_Breast|Lobular_Neoplasia	Atypical Lobular Breast Hyperplasia|ALH|Atypical Breast Lobular Hyperplasia|Atypical Lobular Hyperplasia of Breast|Atypical Lobular Hyperplasia of the Breast
C4731	Neuropathy	Non-Neoplastic_Peripheral_Nervous_System_Disorder	Neuropathy|neuropathy|peripheral neuropathy	A condition of the nervous system that causes numbness, tingling, burning or weakness.  It usually begins in the hands or feet, and can be caused by certain anticancer drugs.
C4732	Neonatal_Hypertension	Hypertension	Neonatal Hypertension
C4733	Peutz-Jeghers_Polyp	Gastrointestinal_Polyp|Hamartomatous_Polyp	Peutz-Jeghers Polyp|Peutz Jeghers Polyp	Peutz-Jeghers polyps occur within the stomach, small and large intestines, and rarely within esophagus, nasopharynx and the urinary tract.  The Peutz-Jeghers polyps are grossly lobulated and dark.  Microscopically, they have a central core of smooth muscle covered by mucosa.  The smooth muscle shows tree-like branching.  The question of whether or not the Peutz-Jeghers polyp is precancerous is a matter of controversy.  The loss of heterozygosity on chromosome 19p (where the responsible gene LKB1 is located) suggests that the increased risk of malignancy may be due to malignant transformation from hamartoma to adenocarcinoma. --2002
C4734	Non-Secretory_Myeloma	Plasma_Cell_Myeloma	Non-Secretory Myeloma
C4735	Low-Grade_T-Cell_Lymphoma	Low-Grade_Lymphoma	Low Grade T-Cell Lymphoma
C4736	High-Grade_T-Cell_Lymphoma	High-Grade_Lymphoma	High Grade T-Cell Lymphoma
C4737	Enteropathy-Type_T-Cell_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Enteropathy-type T-Cell Lymphoma|Enteropathy associated T-cell lymphoma|Intestinal T-Cell Lymphoma	A mature T-cell non-Hodgkin's lymphoma, also known as intestinal T-cell lymphoma.  This disease is uncommon in most parts of the world, but is seen with increasing frequency in those areas with a high prevalence of celiac disease.  The prognosis is poor.  (WHO, 2001) -- 2003
C4738	Desmoplastic_Infantile_Ganglioglioma	Benign_Childhood_Cerebral_Neoplasm|Neuronal_and_Mixed_Neuronal-Glial_Tumor	Desmoplastic Infantile Ganglioglioma|DIG	A WHO grade I large cystic tumor that occurs almost exclusively in infants, with a prominent desmoplastic stroma having a neuroepithelial population of neoplastic astrocytes together with a variable neuronal component. They involve the superficial cerebral cortex and leptomeninges, and often attach to the dura. Although clinically they present as large tumors, they generally have a good prognosis following surgical resection. (Adapted from WHO 2000.) - 2004
C4739	Acrosyringeal_Nevus	Non-Neoplastic_Nevus	Acrosyringeal Nevus
C4740	Porokeratotic_Eccrine_Ostial_and_Dermal_Duct_Nevus	Eccrine_Sweat_Gland_Hamartoma	Porokeratotic Eccrine Ostial and Dermal Duct Nevus|Linear Eccrine Nevus with Comedones|Porokeratotic Eccrine Duct and Hair Follicle Nevus
C4741	Neoplasm_by_Morphology	Neoplasm	Neoplasm by Morphology
C4742	Benign_Squamous_Cell_Neoplasm	Squamous_Cell_Neoplasm	Benign Squamous Cell Neoplasm|Benign Epidermoid Cell Neoplasm|Benign Epidermoid Cell Tumor|Benign Squamous Cell Tumor
C4743	Benign_Basal_Cell_Neoplasm	Basal_Cell_Neoplasm	Benign Basal Cell Neoplasm|Benign Basal Cell Tumor
C4744	Coccygeal_Body_Neoplasm	Bone_Neoplasm	Coccygeal Body Neoplasm|Coccygeal Body Tumor|Glomus Coccygeum Neoplasm|Glomus Coccygeum Tumor
C4746	Benign_Brenner_Tumor	Benign_Ovarian_Transitional_Cell_Tumor|Brenner_Tumor_of_the_Ovary	Benign Ovarian Brenner Tumor|Benign Brenner Neoplasm of Ovary|Benign Brenner Neoplasm of the Ovary|Benign Brenner Tumor of Ovary|Benign Brenner Tumor of the Ovary|Benign Ovarian Brenner Neoplasm	A Brenner tumor in which the cellular population is cytologically benign and there is no stromal invasion present. --2002
C4747	Neuronal_and_Mixed_Neuronal-Glial_Tumor	Central_Nervous_System_Neoplasm|Neuroepithelial_Neoplasm	Neuronal and Mixed Neuronal-Glial Tumor|Neuronal and Glio-Neuronal Neoplasm|Neuronal and Glio-Neuronal Tumor	Neuronal and Mixed Neuronal-Glial Tumors have in common a variable amount of neuronal and, less consistently, glial differentiation. They occur at a low frequency and usually carry a favorable prognosis. They include: Gangliocytoma, Ganglioglioma, Dysembryoplastic Neuroepithelial Tumor, Central Neurocytoma, Cerebellar Liponeurocytoma and Paraganglioma. (Adapted from WHO.)
C4748	Malignant_Melanocytic_Peripheral_Nerve_Sheath_Tumor	Malignant_Peripheral_Nerve_Sheath_Tumor	Malignant Melanocytic Peripheral Nerve Sheath Tumor|Malignant Melanocytic Neoplasm of Peripheral Nerve Sheath|Malignant Melanocytic Neoplasm of the Peripheral Nerve Sheath|Melanocytic MPNST	Melanotic MPNST is a rare variant of Malignant Peripheral Nerve Sheath Tumor (MPNST).
C4749	Basal_Cell_Nevus_with_Comedones	Pilosebaceous_Hamartoma	Basal Cell Nevus with Comedones
C4750	Skin_Unilateral_Segmental_Cavernous_Hemangioma	Cavernous_Hemangioma|Hemangioma_of_the_Skin	Skin Unilateral Segmental Cavernous Hemangioma|Dermal Unilateral Segmental Cavernous Angioma|Dermal Unilateral Segmental Cavernous Hemangioma|Skin Unilateral Segmental Cavernous Angioma|Unilateral Segmental Cavernous Angioma of Skin|Unilateral Segmental Cavernous Angioma of the Skin|Unilateral Segmental Cavernous Hemangioma of Skin|Unilateral Segmental Cavernous Hemangioma of the Skin
C4751	Pigmented_Spindle_Cell_Nevus	Spitz_Spindle_Cell_Nevus	Pigmented Spindle Cell Nevus|Spindle Cell Nevus of Reed
C4752	T-Cell_Prolymphocytic_Leukemia	Mature_T-Cell_and_NK-Cell_Neoplasm|Prolymphocytic_Leukemia	T-Cell Prolymphocytic Leukemia|T Cell Prolymphocytic Leukemia|T Prolymphocytic Leukemia	An aggressive T-cell leukemia, characterized by the proliferation of small to medium sized prolymphocytes with a mature T-cell phenotype, involving the blood, bone marrow, lymph nodes, liver, spleen, and skin.  (WHO, 2001) -- 2003
C4753	B-Cell_Prolymphocytic_Leukemia	Mature_B-Cell_Lymphocytic_Neoplasm|Prolymphocytic_Leukemia	B-Cell Prolymphocytic Leukemia|B Prolymphocytic Leukemia	A malignant B-cell lymphoproliferative process affecting the blood, bone marrow, and spleen.  The B-prolymphocytes are medium-sized, round lymphoid cells with prominent nucleoli.  The B-prolymphocytes must exceed 55% of lymphoid cells in the blood.  Cases of transformed chronic lymphocytic leukemia (CLL) and CLL with increased prolymphocytes are excluded.  The prognosis is poor.  (WHO, 2001) -- 2003
C4754	Spindle_Cell_Hemangioma	Hemangioma	Spindle Cell Hemangioma|SCH|Spindle -Cell Hemangioma|Spindle Cell Hemangioendothelioma
C4755	Chondrogenic_Neoplasm	Mesenchymal_Cell_Neoplasm	Chondrogenic Neoplasm|Cartilaginous Neoplasm|Cartilaginous Tumor|Chondrogenic Tumor|Chondromatous Neoplasm|Chondromatous Tumor|Neoplasm of Cartilage|Neoplasm of the Cartilage|Tumor of Cartilage|Tumor of the Cartilage
C4756	Vulvar_Intraepithelial_Neoplasia	Female_Reproductive_System_Precancerous_Condition|Squamous_Cell_Intraepithelial_Neoplasia|Vulvar_Squamous_Neoplasm	Vulvar Intraepithelial Neoplasia|Dysplasia of Vulva|Dysplasia of the Vulva|Intraepithelial Neoplasia of Vulva|Intraepithelial Neoplasia of the Vulva|VIN|Vulva Dysplasia|Vulva Intraepithelial Neoplasia|Vulval Dysplasia|Vulval Intraepithelial Neoplasia|Vulvar Dysplasia
C4757	Hypertensive_Nephropathy	Nephropathy	Hypertensive Nephropathy
C4758	Metastatic_Neoplasm_to_the_Liver	Hepatic_Disorder|Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Malignant_Hepato-Biliary_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Liver|Liver Metastases|Liver Metastasis|Metastatic Neoplasm to the Liver|Metastatic Tumor to the Liver|liver metastases	A malignant neoplasm that has spread to the liver from another (primary) anatomic site.  Such malignant neoplasms may be carcinomas (e.g. breast, colon), lymphomas, melanomas, or sarcomas. -- 2004
C4759	Oral_Cavity_Cyst	Cyst|Head_and_Neck_Finding	Oral Cavity Cyst|Cyst of Mouth|Cyst of Oral Cavity|Cyst of the Mouth|Cyst of the Oral Cavity|Mouth Cyst
C4760	Low_Grade_Vulvar_Intraepithelial_Neoplasia	Low_Grade_Squamous_Intraepithelial_Neoplasia|Vulvar_Intraepithelial_Neoplasia	Low Grade Vulvar Intraepithelial Neoplasia|Grade 1 VIN|Grade 1 Vulvar Intraepithelial Neoplasia|Grade I VIN|Grade I Vulvar Intraepithelial Neoplasia|Intraepithelial Neoplasia of Vulva Grade 1|Intraepithelial Neoplasia of the Vulva Grade 1|Low Grade VIN|VIN Grade 1|Vulva Intraepithelial Neoplasia Grade 1|Vulvar Intraepithelial Neoplasia Grade 1
C4761	Grade_II_Vulvar_Intraepithelial_Neoplasia	High_Grade_Vulvar_Intraepithelial_Neoplasia	Grade 2 Vulvar Intraepithelial Neoplasia|Grade 2 VIN|Grade II VIN|Grade II Vulvar Intraepithelial Neoplasia|Intraepithelial Neoplasia of Vulva Grade 2|Intraepithelial Neoplasia of the Vulva Grade 2|VIN Grade 2|Vulva Intraepithelial Neoplasia Grade 2|Vulvar Intraepithelial Neoplasia Grade 2
C4762	Malignant_Major_Salivary_Gland_Neoplasm	Major_Salivary_Gland_Neoplasm|Malignant_Salivary_Gland_Neoplasm	Malignant Major Salivary Gland Neoplasm|Malignant Major Salivary Gland Tumor|Malignant Neoplasm of Major Salivary Gland|Malignant Neoplasm of the Major Salivary Gland|Malignant Tumor of Major Salivary Gland|Malignant Tumor of the Major Salivary Gland
C4763	Malignant_Neoplasm_of_the_Cervical_Esophagus	Malignant_Esophageal_Neoplasm_by_Anatomic_Region|Malignant_Neoplasm_of_the_Upper_Third_of_the_Esophagus	Malignant Neoplasm of the Cervical Esophagus|Malignant Neoplasm of Cervical Esophagus	Clinical esophageal segment composed of skeletal muscle.  It corresponds to the superior part of the upper third topographic segment of the esophagus.
C4764	Malignant_Neoplasm_of_the_Abdominal_Esophagus	Malignant_Esophageal_Neoplasm_by_Anatomic_Region|Malignant_Neoplasm_of_the_Lower_Third_of_the_Esophagus	Malignant Neoplasm of the Abdominal Esophagus|Malignant Neoplasm of Abdominal Esophagus|Malignant Tumor of Abdominal Esophagus|Malignant Tumor of the Abdominal Esophagus	Clinical esophageal segment composed of smooth muscle.  It corresponds to the inferior part of the lower third topographic segment of the esophagus.
C4765	Malignant_Middle_Ear_Neoplasm	Malignant_Ear_Neoplasm|Middle_Ear_Neoplasm	Malignant Middle Ear Neoplasm|Malignant Middle Ear Tumor|Malignant Neoplasm of Middle Ear|Malignant Neoplasm of the Middle Ear|Malignant Tumor of Middle Ear|Malignant Tumor of the Middle Ear	Malignant neoplasm originating in the middle ear.
C4766	Malignant_Ciliary_Body_Neoplasm	Ciliary_Body_Neoplasm|Malignant_Uveal_Neoplasm	Malignant Ciliary Body Neoplasm|Malignant Ciliary Body Tumor|Malignant Neoplasm of Ciliary Body|Malignant Neoplasm of the Ciliary Body|Malignant Tumor of Ciliary Body|Malignant Tumor of the Ciliary Body
C4767	Malignant_Eye_Neoplasm	Eye_Neoplasm	Malignant Eye Neoplasm|Cancer of Eye|Cancer of the Eye|Eye Cancer|Eye Neoplasm, Malignant|Malignant Eye Tumor|Malignant Neoplasm of Eye|Malignant Neoplasm of the Eye|Malignant Ocular Neoplasm|Malignant Ocular Tumor|Malignant Tumor of Eye|Malignant Tumor of the Eye	A primary or metastatic tumor involving the structures of the eye (conjunctiva, cornea, uvea, retina), the lacrimal gland, and the orbit.  Representative examples are melanoma, carcinoma, lymphoma, and retinoblastoma. -- 2004
C4768	Malignant_Olfactory_Nerve_Neoplasm	Malignant_Cranial_Nerve_Neoplasm|Olfactory_Nerve_Neoplasm	Malignant Olfactory Nerve Neoplasm|Malignant First Cranial Nerve Neoplasm|Malignant First Cranial Nerve Tumor|Malignant Neoplasm of First Cranial Nerve|Malignant Neoplasm of Olfactory Nerve|Malignant Neoplasm of the First Cranial Nerve|Malignant Neoplasm of the Olfactory Nerve|Malignant Olfactory Nerve Tumor|Malignant Tumor of First Cranial Nerve|Malignant Tumor of Olfactory Nerve|Malignant Tumor of the First Cranial Nerve|Malignant Tumor of the Olfactory Nerve	Abnormal malignant growth of the cells that comprise cranial nerve I. This can lead to difficulties with the sense of smell. Since taste and smell are intimately linked in terms of the enjoyment of food, a deficiency in the ability to smell can lead to decreased food intake with possible malnutrition.
C4769	Malignant_Pituitary_Gland_Neoplasm	Malignant_Supratentorial_Neoplasm|Pituitary_Gland_Neoplasm	Malignant Pituitary Gland Neoplasm|Cancer of Pituitary Gland|Cancer of the Pituitary Gland|Malignant Neoplasm of Pituitary|Malignant Neoplasm of Pituitary Gland|Malignant Neoplasm of the Pituitary|Malignant Neoplasm of the Pituitary Gland|Malignant Pituitary Gland Tumor|Malignant Pituitary Neoplasm|Malignant Pituitary Tumor|Malignant Tumor of Pituitary|Malignant Tumor of Pituitary Gland|Malignant Tumor of the Pituitary|Malignant Tumor of the Pituitary Gland|Pituitary Gland Cancer|Pituitary Neoplasms, Malignant|Pituitary Tumor, Malignant	A primary or metastatic malignant neoplasm affecting the pituitary gland.  Representative examples include functioning or non-functioning carcinomas arising from the anterior lobe of the pituitary gland, chordomas, chondrosarcomas, and metastatic carcinomas from the breast, lung, and gastrointestinal tract. (NCI05)
C4770	Benign_Parotid_Gland_Neoplasm	Benign_Major_Salivary_Gland_Neoplasm|Parotid_Gland_Neoplasm	Benign Parotid Gland Neoplasm|Benign Neoplasm of Parotid|Benign Neoplasm of Parotid Gland|Benign Neoplasm of the Parotid|Benign Neoplasm of the Parotid Gland|Benign Parotid Gland Tumor|Benign Parotid Neoplasm|Benign Parotid Tumor|Benign Tumor of Parotid|Benign Tumor of Parotid Gland|Benign Tumor of the Parotid|Benign Tumor of the Parotid Gland
C4771	Benign_Major_Salivary_Gland_Neoplasm	Benign_Salivary_Gland_Neoplasm|Major_Salivary_Gland_Neoplasm	Benign Major Salivary Gland Neoplasm|Benign Major Salivary Gland Tumor|Benign Neoplasm of Major Salivary Gland|Benign Neoplasm of the Major Salivary Gland|Benign Tumor of Major Salivary Gland|Benign Tumor of the Major Salivary Gland
C4772	Benign_Cecum_Neoplasm	Benign_Colon_Neoplasm|Cecum_Neoplasm	Benign Cecum Neoplasm|Benign Cecum Tumor|Benign Neoplasm of Cecum|Benign Neoplasm of the Cecum|Benign Tumor of Cecum|Benign Tumor of the Cecum
C4773	Benign_Appendix_Neoplasm	Appendix_Neoplasm|Benign_Gastrointestinal_Neoplasm	Benign Appendix Neoplasm|Benign Appendix Tumor|Benign Neoplasm of Appendix|Benign Neoplasm of the Appendix|Benign Tumor of Appendix|Benign Tumor of the Appendix
C4774	Benign_Rectal_Neoplasm	Benign_Colorectal_Neoplasm|Rectal_Neoplasm	Benign Rectal Neoplasm|Benign Neoplasm of Rectum|Benign Neoplasm of the Rectum|Benign Rectal Neoplasms|Benign Rectal Tumor|Benign Rectal Tumors|Benign Tumor of Rectum|Benign Tumor of the Rectum|Rectal Neoplasms, Benign|Rectal Tumors, Benign
C4775	Benign_Duodenal_Neoplasm	Benign_Small_Intestinal_Neoplasm|Duodenal_Neoplasm	Benign Duodenal Neoplasm|Benign Duodenal Tumor|Benign Neoplasm of Duodenum|Benign Neoplasm of the Duodenum|Benign Tumor of Duodenum|Benign Tumor of the Duodenum
C4776	Benign_Extrahepatic_Bile_Duct_Neoplasm	Extrahepatic_Bile_Duct_Neoplasm	Benign Extrahepatic Bile Duct Neoplasm|Benign Extrahepatic Bile Duct Tumor|Benign Neoplasm of Extrahepatic Bile Duct|Benign Neoplasm of the Extrahepatic Bile Duct|Benign Tumor of Extrahepatic Bile Duct|Benign Tumor of the Extrahepatic Bile Duct
C4777	Benign_Male_Reproductive_System_Neoplasm	Benign_Reproductive_System_Neoplasm|Male_Reproductive_System_Neoplasm	Benign Male Reproductive System Neoplasm|Benign Male Reproductive System Tumor
C4778	Benign_Renal_Neoplasm	Benign_Urinary_Tract_Neoplasm|Renal_Neoplasm	Benign Renal Neoplasm|Benign Kidney Neoplasm|Benign Kidney Tumor|Benign Neoplasm of Kidney|Benign Neoplasm of the Kidney|Benign Renal Tumor|Benign Renal Tumors|Benign Tumor of Kidney|Benign Tumor of the Kidney|Renal Neoplasm, Benign|Renal Tumor, Benign	Abnormal growth of the tissue of the kidney without malignant elements. The most common of these lesions is the renal cyst, comprising approximately 70% of benign renal lesions. (ed. Walsh PC, Retik AB, Vaughn ED, Wein AJ. Campbell's Urology, p.2285 Volume 3, 7th edition WB Saunders)
C4779	Benign_Ciliary_Body_Neoplasm	Benign_Uveal_Neoplasm|Ciliary_Body_Neoplasm	Benign Ciliary Body Neoplasm|Benign Ciliary Body Tumor|Benign Neoplasm of Ciliary Body|Benign Neoplasm of the Ciliary Body|Benign Tumor of Ciliary Body|Benign Tumor of the Ciliary Body
C4780	Benign_Eye_Neoplasm	Eye_Neoplasm	Benign Eye Neoplasm|Benign Eye Neoplasm NOS|Benign Eye Tumor|Benign Neoplasm of Eye|Benign Neoplasm of the Eye|Benign Ocular Neoplasm|Benign Ocular Tumor|Benign Tumor of Eye|Benign Tumor of the Eye	Abnormal growth of the cells of the eye including but not limited to choroid, ciliary body, retina, sclera that is determined to be benign
C4781	Benign_Brain_Neoplasm	Benign_Intracranial_Neoplasm|Brain_Neoplasm	Benign Brain Neoplasm|Benign Brain Tumor|Benign Neoplasm of Brain|Benign Neoplasm of the Brain|Benign Tumor of Brain|Benign Tumor of the Brain|Brain Neoplasms, Benign	Primary neoplasms of the brain which are noninvasive and tend to grow slowly.  They are generally classified by location and histologic type.  In children, astrocytomas of the cerebellum represent relatively common benign brain neoplasms.  In adult meningiomas, neurilemomas and pituitary tumors comprise the majority of benign tumors.  (KEV 8-14-99)
C4782	Benign_Pituitary_Gland_Neoplasm	Benign_Supratentorial_Neoplasm|Pituitary_Gland_Neoplasm	Benign Pituitary Gland Neoplasm|Benign Neoplasm of Pituitary|Benign Neoplasm of Pituitary Gland|Benign Neoplasm of the Pituitary|Benign Neoplasm of the Pituitary Gland|Benign Pituitary Gland Tumor|Benign Pituitary Neoplasm|Benign Pituitary Tumor|Benign Tumor of Pituitary|Benign Tumor of Pituitary Gland|Benign Tumor of the Pituitary|Benign Tumor of the Pituitary Gland|Pituitary Neoplasms, Benign|Pituitary Tumor, Benign	A neoplasm without metastatic potential arising from the anterior or the posterior lobe of the pituitary gland.  The vast majority are adenomas. (NCI05)
C4783	Borderline_Ovarian_Epithelial_Neoplasm	Infrequent_Neoplasm|Neoplasm_of_Uncertain_Malignant_Potential|Ovarian_Epithelial_Neoplasm	Borderline Ovarian Surface Epithelial-Stromal Tumor|Borderline Epithelial Neoplasm of Ovary|Borderline Epithelial Neoplasm of the Ovary|Borderline Epithelial Tumor of Ovary|Borderline Epithelial Tumor of the Ovary|Borderline Ovarian Epithelial Neoplasm|Epithelial Neoplasm of Ovary of Borderline Malignancy|Epithelial Neoplasm of the Ovary of Borderline Malignancy|Epithelial Ovarian Neoplasm of Borderline Malignancy|Epithelial Ovarian Tumor of Borderline Malignancy|Epithelial Tumor of Ovary of Borderline Malignancy|Epithelial Tumor of the Ovary of Borderline Malignancy	An epithelial tumor arising from the ovary without definitive morphologic characteristics of malignancy.  --2003
C4784	Cardiovascular_Neoplasm	Cardiovascular_Disorder|Neoplasm_by_Site	Cardiovascular Neoplasm|Cardiovascular Neoplasms|Cardiovascular Tumor|Cardiovascular Tumors|Neoplasms, Cardiovascular|Tumors, Cardiovascular	A neoplasm of the heart and/or blood vessels without specification as to whether it is benign or malignant.
C4785	Uncomplicated_Hypertension	Hypertension	Uncomplicated Hypertension
C4786	Dementia	Neurodegenerative_Disorder	Dementia	loss of intellectual functions such as memory, learning, reasoning, problem solving, and abstract thinking while vegetative functions remain intact.
C4787	Benign_Gastrointestinal_Neoplasm	Gastrointestinal_Neoplasm	Benign Gastrointestinal Neoplasm|Benign Digestive Tract Neoplasm|Benign Digestive Tract Tumor|Benign GI Neoplasm|Benign GI Tract Neoplasm|Benign GI Tract Tumor|Benign GI Tumor|Benign Gastrointestinal Tract Tumor|Benign Gastrointestinal Tumor|Benign Neoplasm of Digestive Tract|Benign Neoplasm of Gastrointestinal Tract|Benign Neoplasm of the Digestive Tract|Benign Tumor of Digestive Tract|Benign Tumor of GI Tract|Benign Tumor of Gastrointestinal Tract|Benign Tumor of the Digestive Tract|Benign Tumor of the GI Tract|Benign Tumor of the Gastrointestinal Tract	Benign neoplasms of the gastrointestinal tract, which includes the oral cavity, pharynx, esophagus, stomach, intestines, rectus and anus and other structures involved with digestion.
C4788	Malignant_Nervous_System_Neoplasm	Nervous_System_Neoplasm	Malignant Nervous System Neoplasm|Malignant Neoplasm of Nervous System|Malignant Neoplasm of the Nervous System|Malignant Nervous System Tumor|Malignant Tumor of Nervous System|Malignant Tumor of the Nervous System|Nervous System Neoplasms, Malignant	A primary or metastatic malignant neoplasm involving the nervous system.
C4789	Benign_Nervous_System_Neoplasm	Nervous_System_Neoplasm	Benign Nervous System Neoplasm|Benign Neoplasm of Nervous System|Benign Neoplasm of the Nervous System|Benign Nervous System Tumor|Benign Tumor of Nervous System|Benign Tumor of the Nervous System|Nervous System Neoplasm, Benign	Abnormal growth of cells in the nervous system without evidence of malignant characteristics. Unlike other organ systems, tumors in the central nervous system can have benign histological characteristics but still have life threatening effects due to their location within the neuraxis (e.g., brainstem gliomas).
C4791	Left_Atrial_Myxoma	Atrial_Myxoma	Left Atrial Myxoma|Myxoma of Left Atrium|Myxoma of the Left Atrium	Abnormal growth of muscle in the left atrium which may cause obstruction to the outflow tract at that location
C4792	Right_Atrial_Myxoma	Atrial_Myxoma	Right Atrial Myxoma|Myxoma of Right Atrium|Myxoma of the Right Atrium
C4793	Colon_Lymphoma	Gastrointestinal_Lymphoma|Malignant_Colon_Neoplasm	Colon Lymphoma|Colonic Lymphoma|Lymphoma of Colon|Lymphoma of the Colon|Primary Colon Lymphoma
C4794	Lung_Lymphoma	Lymphoma_by_Site|Malignant_Lung_Neoplasm	Lung Lymphoma|Lymphoma of Lung|Lymphoma of the Lung|Primary Lung Lymphoma|Pulmonary Lymphoma
C4795	Prostate_Adenoma	Adenoma|Benign_Prostate_Neoplasm	Prostate Adenoma|Adenoma of Prostate|Adenoma of the Prostate	This is a non-cancerous growth found in the prostate.
C4796	Hypertensive_Episode	Non-Neoplastic_Vascular_Disorder	Hypertensive Episode
C4797	Perineural_Cyst	Cyst	Perineural Cyst|Cyst of Nerve Root|Cyst of the Nerve Root|Nerve Root Cyst
C4798	Recurrent_Neoplasm	Neoplasm_by_Special_Category	Recurrent Neoplasm|Neoplasm Recurrence|Recurrent Tumor	The reemergence of neoplasm after a period of remission
C4799	Deficiency_of_Humoral_Immunity	Immunodeficiency_Syndrome	Deficiency of Humoral Immunity|B-Cell Deficiency
C4800	Retinal_Neoplasm	Eye_Neoplasm	Retinal Neoplasm|Neoplasm of Retina|Neoplasm of the Retina|Retina Neoplasm|Retina Tumor|Retinal Tumor|Tumor of Retina|Tumor of the Retina
C4801	Optic_Nerve_Neoplasm	Cranial_Nerve_Neoplasm|Oculomotor_Nerve_Disorder|Visual_Pathway_Neoplasm	Optic Nerve Neoplasm|Cranial Nerve II Neoplasms|Neoplasm of Optic Nerve|Neoplasm of Second Cranial Nerve|Neoplasm of the Optic Nerve|Neoplasm of the Second Cranial Nerve|Neoplasms, Optic Nerve|Neoplasms, Second Cranial Nerve|Optic Nerve Neoplasms|Optic Nerve Tumor|Second Cranial Nerve Neoplasm|Second Cranial Nerve Neoplasms|Second Cranial Nerve Tumor|Tumor of Optic Nerve|Tumor of Second Cranial Nerve|Tumor of the Optic Nerve|Tumor of the Second Cranial Nerve	Benign and malignant neoplasms which arise from or metastasize to the optic or second cranial nerve which extends from the optic disc of the eye and joins the optic chiasm.  Clinical features may include visual loss, proptosis, and local pain.  The majority of optic nerve tumors or optic gliomas. (KEV 8-8-99)
C4802	Neurodegenerative_Disorder	Degenerative_Disorder|Non-Neoplastic_Central_Nervous_System_Disorder	Neurodegenerative Disorder|Neurodegenerative Diseases	A disorder of the central nervous system characterized by gradual and progressive loss of neural tissue and neurologic function. --2004
C4803	Duodenal_Carcinoma	Malignant_Duodenal_Neoplasm|Small_Intestinal_Carcinoma	Duodenal Carcinoma|Cancer of Duodenum|Cancer of the Duodenum|Carcinoma of Duodenum|Carcinoma of the Duodenum|Duodenal Cancer
C4804	Breast_Hyperplasia	Breast_Neoplasm|Hyperplasia	Breast Hyperplasia
C4805	Acquired_Spider_Nevus	Spider_Nevus	Acquired Nevus Araneus|Acquired Spider Nevus
C4806	Congenital_Spider_Nevus	Spider_Nevus	Congenital Nevus Araneus|Congenital Spider Nevus
C4807	Cerebral_Meningioma	Cerebral_Neoplasm|Supratentorial_Meningioma	Cerebral Meningioma|Cerebral Hemispheric Meningioma|Meningioma of Cerebral Hemispheres|Meningioma of Cerebrum|Meningioma of the Cerebral Hemispheres|Meningioma of the Cerebrum
C4808	Late_Effects	Side_Effect	Late Effects|Adverse Late Effects	Symptoms and conditions which are the result of treatment but arise months or years after the therapy.
C4809	Residual_Disease	Clinical_Course_of_Disease	Residual Disease|residual disease	Cancer cells that remain after attempts to remove the cancer have been made.
C4810	Malignant_Sweat_Gland_Neoplasm	Malignant_Skin_Appendage_Neoplasm|Sweat_Gland_Neoplasm	Malignant Sweat Gland Neoplasm|Malignant Neoplasm of Sweat Gland|Malignant Neoplasm of the Sweat Gland|Malignant Tumor of Sweat Gland|Malignant Tumor of the Sweat Gland|Sweat Gland Neoplasms, Malignant
C4811	Fibromatosis_Colli	Fibromatosis	Fibromatosis Colli
C4812	Malignant_Odontogenic_Neoplasm	Odontogenic_Neoplasm	Malignant Odontogenic Neoplasm|Malignant Odontogenic Tumor|Odontogenic Carcinoma|Odontogenic Carcinosarcoma
C4813	Recurrent_Malignant_Neoplasm	Malignant_Neoplasm|Recurrent_Neoplasm	Recurrent Malignant Neoplasm|Recurrent Cancer|Recurrent Malignant Tumor|recurrent cancer	A malignant tumor which reappears in an individual following a remission. -- 2003
C4815	Thyroid_Carcinoma	Malignant_Thyroid_Neoplasm|Neck_Carcinoma	Thyroid Gland Carcinoma|Cancer of Thyroid|Cancer of the Thyroid|Carcinoma of Thyroid|Carcinoma of Thyroid Gland|Carcinoma of the Thyroid|Carcinoma of the Thyroid Gland|Head and Neck Cancer, Thyroid|Thyroid Cancer|Thyroid Carcinoma	A carcinoma arising from the thyroid gland.  It is usually an adenocarcinoma and includes the following main subtypes: follicular, papillary, medullary, poorly differentiated, and anaplastic. --2003
C4816	Photosensitive_Dermatitis	Dermatitis	Photosensitive Dermatitis|Photosensitivity Reaction
C4817	Ewing_s_Sarcoma	Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor	Ewing's Sarcoma|Ewing's Tumor|Ewing's sarcoma	(YOO-ingz sar-KO-ma) A type of bone cancer that usually forms in the middle (shaft) of large bones. Also called Ewing's sarcoma/primitive neuroectodermal tumor (PNET).
C4818	Calcifying_Aponeurotic_Fibroma	Dermal_Fibroma	Calcifying Aponeurotic Fibroma|Juvenile Aponeurotic Fibroma|Juvenile Aponeurotic Fibrosis
C4819	Skin_Squamous_Cell_Carcinoma	Common_Carcinoma|Skin_Carcinoma|Squamous_Cell_Carcinoma	Skin Squamous Cell Carcinoma|Cutaneous Squamous Cell Carcinoma|Epidermoid Carcinoma of Skin|Epidermoid Carcinoma of the Skin|Epidermoid Skin Carcinoma|Squamous Cell Carcinoma of Skin|Squamous Cell Carcinoma of the Skin|Squamous Cell Skin Carcinoma	A carcinoma arising from the squamous cells of the epidermis.  Skin squamous cell carcinoma is most commonly found on sun-exposed areas.  The majority of the tumors are well-differentiated. --2002
C4820	Anogenital_Human_Papilloma_Virus_Infection	Human_Papilloma_Virus_Infection	Anogenital Human Papilloma Virus Infection
C4822	Malignant_Glioma	Neuroglial_Tumor	Malignant Glioma|Malignant Glial Neoplasm|Malignant Glial Tumor|Malignant Neuroglial Neoplasm|Malignant Neuroglial Tumor	A malignant tumor of neuroglial tissue. This term may be used to describe one of a number of primary neoplasms of the brain and spinal cord, including astrocytomas, ependymomas, neurocytomas, etc. Malignant gliomas are the most common primary tumors of the brain. --2004
C4823	Central_Neurocytoma	Retired_Concepts	Central Neurocytoma
C4824	Tongue_Carcinoma	Malignant_Tongue_Neoplasm|Oral_Cavity_Carcinoma	Tongue Carcinoma|Cancer of Tongue|Cancer of the Tongue|Carcinoma of Tongue|Carcinoma of the Tongue|Tongue Cancer	A malignant tumor arising from the epithelium that covers the tongue.  The vast majority of tongue carcinomas are moderately or poorly differentiated squamous cell carcinomas. -- 2004
C4825	Tonsillar_Carcinoma	Malignant_Tonsillar_Neoplasm|Oropharyngeal_Carcinoma	Tonsillar Carcinoma|Cancer of Tonsil|Cancer of the Tonsil|Carcinoma of Tonsil|Carcinoma of the Tonsil|Tonsil Cancer|Tonsil Carcinoma|Tonsillar Cancer	A primary or metastatic carcinoma of the tonsil. --2003
C4826	Cerebral_Neuroblastoma	Malignant_Cerebral_Neoplasm|Neuroblastoma	Cerebral Neuroblastoma|Cerebral Hemispheric Neuroblastoma|Cerebral Neuroblastoma, PNET|Neuroblastoma of Cerebral Hemispheres|Neuroblastoma of Cerebrum|Neuroblastoma of the Cerebral Hemispheres|Neuroblastoma of the Cerebrum
C4827	Adrenal_Neuroblastoma	Malignant_Adrenal_Medulla_Neoplasm|Neuroblastomas_of_the_Adrenal_Gland_and_Sympathetic_Nervous_System	Adrenal Gland Neuroblastoma|Adrenal Neuroblastoma|Neuroblastoma of Adrenal|Neuroblastoma of Adrenal Gland|Neuroblastoma of the Adrenal|Neuroblastoma of the Adrenal Gland
C4828	Primary_Sclerosing_Cholangitis	Cholangitis|Hepato-Biliary_Precancerous_Condition	Primary Sclerosing Cholangitis	recurrent or persistant obstructive jaundice, frequently with ulcerative colitis, due to extensive obliterative fibrosis of the bile ducts.
C4829	Disseminated_Squamous_Cell_Carcinoma	Disseminated_Carcinoma|Metastatic_Squamous_Cell_Carcinoma	Disseminated Squamous Cell Carcinoma
C4830	Ureter_Transitional_Cell_Carcinoma	Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter|Ureter_Carcinoma	Ureter Urothelial Carcinoma|Transitional Cell Carcinoma of Ureter|Transitional Cell Carcinoma of the Ureter|Ureter Transitional Cell Carcinoma|Ureteral Transitional Cell Carcinoma|Ureteral Urothelial Cell Carcinoma|Urothelial Cell Carcinoma of Ureter|Urothelial Cell Carcinoma of the Ureter
C4831	Gingival_Hemangioma	Benign_Gingival_Neoplasm|Hemangioma	Gingival Hemangioma|Angioma of Gingiva|Angioma of Gum|Angioma of the Gingiva|Angioma of the Gum|Gingival Angioma|Gum Angioma|Gum Hemangioma|Hemangioma of Gingiva|Hemangioma of Gum|Hemangioma of the Gingiva|Hemangioma of the Gum
C4832	Retroperitoneal_Sarcoma	Malignant_Retroperitoneal_Neoplasm|Soft_Tissue_Sarcoma	Retroperitoneal Sarcoma
C4833	Oral_Cavity_Squamous_Cell_Carcinoma	Lip_and_Oral_Cavity_Squamous_Cell_Carcinoma|Oral_Cavity_Carcinoma	Oral Cavity Squamous Cell Carcinoma|Mouth SCC|Mouth Squamous Cell Carcinoma|Oral Cavity SCC|SCC of Mouth|SCC of Oral Cavity|SCC of the Mouth|SCC of the Oral Cavity|Squamous Cell Carcinoma of Mouth|Squamous Cell Carcinoma of Oral Cavity|Squamous Cell Carcinoma of the Mouth|Squamous Cell Carcinoma of the Oral Cavity
C4834	Primary_Bone_Osteosarcoma	Bone_Sarcoma|Osteosarcoma	Primary Bone Osteosarcoma|Osteosarcoma of Bone|Primary Osteosarcoma of Bone
C4835	Ewing_s_Sarcoma_of_Bone	Ewing_s_Sarcoma|Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor_of_Bone	Ewing's Sarcoma of Bone|Bone Ewing's Sarcoma|Ewing's Sarcoma, Osseous|Osseous Ewing's Sarcoma|Osseous Ewing's Tumor|Skeletal Ewing's Sarcoma|Skeletal Ewing's Tumor	A small round cell tumor that lacks morphologic, immunohistochemical, and electron microscopic evidence of neuroectodermal differentiation.  It represents one of the two ends of the spectrum called Ewing's sarcoma/peripheral neuroectodermal tumor.  It often affects the diaphysis or metaphyseal-diaphyseal portion of long bones.  Clinical findings include pain and a mass in the involved area.  Fever, anemia, leucocytosis, and an increased sedimentation rate are often seen.  X-ray examination reveals osteolytic lesions.  The prognosis depends on the stage, anatomic location, and size of the tumor. -- 2003
C4836	Malignant_Epiglottis_Neoplasm	Epiglottis_Neoplasm|Malignant_Supraglottis_Neoplasm	Malignant Epiglottis Neoplasm|Malignant Epiglottic Neoplasm|Malignant Epiglottic Tumor|Malignant Epiglottis Tumor|Malignant Neoplasm of Epiglottis|Malignant Neoplasm of the Epiglottis|Malignant Tumor of Epiglottis|Malignant Tumor of the Epiglottis
C4837	Dysplasia_of_Vocal_Cord	Dysplasia_of_Larynx	Dysplasia of Vocal Cord
C4838	Dysplasia_of_Larynx	Dysplasia	Dysplasia of Larynx
C4839	Esophageal_Intraepithelial_Neoplasia	Esophageal_Neoplasm|Esophageal_Precancerous_Condition|Gastrointestinal_Intraepithelial_Neoplasia	Esophageal Intraepithelial Neoplasia|Esophageal Dysplasia|Intraepithelial Neoplasia of Esophagus|Intraepithelial Neoplasia of the Esophagus	A lesion that is characterized by architectural and cytologic abnormalities of the esophageal epithelium, and carries a predisposition for progression to invasive carcinoma.  Intraepithelial neoplasia (dysplasia) of the esophagus is graded as low or high grade.  In this two-tier system, severe dysplasia and carcinoma in situ are included under the rubric of high grade intraepithelial neoplasia and may have the same clinical implications.  (WHO, 2000) -- 2003
C4840	Esophageal_Low-Grade_Intraepithelial_Neoplasia	Esophageal_Intraepithelial_Neoplasia|Low_Grade_Intraepithelial_Neoplasia	Esophageal Low Grade Intraepithelial Neoplasia	A lesion in which the architectural and cytologic abnormalities are confined to the lower half of the esophageal epithelium.  (WHO, 2000) -- 2003
C4841	Moderate_Esophageal_Dysplasia	Moderate_Dysplasia	Moderate Esophageal Dysplasia
C4843	Biliary_Tract_Intraepithelial_Neoplasia	Bile_Duct_Neoplasm|Gastrointestinal_Intraepithelial_Neoplasia|Glandular_Cell_Intraepithelial_Neoplasia|Hepato-Biliary_Precancerous_Condition	Biliary Tract Intraepithelial Neoplasia|Biliary Tract Dysplasia
C4844	Mild_Biliary_Tract_Dysplasia	Mild_Dysplasia	Mild Biliary Tract Dysplasia
C4845	Pancreatic_Intraepithelial_Neoplasia	Gastrointestinal_Intraepithelial_Neoplasia|Glandular_Cell_Intraepithelial_Neoplasia|Pancreatic_Precancerous_Condition	Pancreatic Intraepithelial Neoplasia|Duct Dysplasia of Pancreas|Duct Dysplasia of the Pancreas|Ductal Dysplasia of Pancreas|Ductal Dysplasia of the Pancreas|PanIN|Pancreatic Duct Dysplasia|Pancreatic Ductal Dysplasia	Pancreatic intraepithelial neoplasia (PanIN) is a recently adopted term to describe precancerous pancreatic duct lesions. --2002
C4846	Grade_II_Pancreatic_Intraepithelial_Neoplasia	Grade_II_Glandular_Intraepithelial_Neoplasia|Pancreatic_Intraepithelial_Neoplasia	Grade II Pancreatic Intraepithelial Neoplasia|Grade 2 Pancreatic Intraepithelial Neoplasia|Moderate Duct Dysplasia of Pancreas|Moderate Duct Dysplasia of the Pancreas|Moderate Ductal Dysplasia of Pancreas|Moderate Ductal Dysplasia of the Pancreas|Moderate Pancreatic Duct Dysplasia|Moderate Pancreatic Ductal Dysplasia
C4847	Colon_Dysplasia	Dysplasia	Colon Dysplasia|Colonic Dysplasia|Colorectal Dysplasia|Dysplasia of Colon|Dysplasia of Large Bowel|Dysplasia of Large Intestine|Dysplasia of the Colon|Dysplasia of the Large Bowel|Dysplasia of the Large Intestine|Large Bowel Dysplasia|Large Intestine Dysplasia
C4848	Mild_Colon_Dysplasia	Colon_Dysplasia	Mild Colon Dysplasia|Low Grade Colon Dysplasia|Low Grade Colonic Dysplasia|Low Grade Dysplasia of Colon|Low Grade Dysplasia of the Colon|Low-Grade Colon Dysplasia|Low-Grade Colonic Dysplasia|Low-Grade Colorectal Dysplasia|Low-Grade Dysplasia of Colon|Low-Grade Dysplasia of the Colon|Mild Colonic Dysplasia|Mild Colorectal Dysplasia|Mild Dysplasia of Colon|Mild Dysplasia of Large Bowel|Mild Dysplasia of the Colon|Mild Dysplasia of the Large Bowel|Mild Large Bowel Dysplasia
C4849	Moderate_Colon_Dysplasia	Colon_Dysplasia	Moderate Colon Dysplasia|Moderate Colonic Dysplasia|Moderate Colorectal Dysplasia|Moderate Dysplasia of Colon|Moderate Dysplasia of Large Bowel|Moderate Dysplasia of the Colon|Moderate Dysplasia of the Large Bowel|Moderate Large Bowel Dysplasia
C4850	Rectal_Dysplasia	Dysplasia	Rectal Dysplasia|Dysplasia of Rectum|Dysplasia of the Rectum
C4851	Mild_Rectal_Dysplasia	Rectal_Dysplasia	Mild Rectal Dysplasia|Mild Dysplasia of Rectum|Mild Dysplasia of the Rectum
C4852	Moderate_Rectal_Dysplasia	Rectal_Dysplasia	Moderate Rectal Dysplasia|Moderate Dysplasia of Rectum|Moderate Dysplasia of the Rectum
C4853	Stage_0_Rectal_Cancer	Colorectal_High-Grade_Intraepithelial_Neoplasia|Rectal_Carcinoma|Stage_0_Colorectal_Cancer	Stage 0 Rectal Cancer|Carcinoma in situ of Rectum|Carcinoma in situ of the Rectum|Marked Dysplasia of Rectum|Marked Dysplasia of the Rectum|Marked Rectal Dysplasia|Rectal Carcinoma in situ|Severe Dysplasia of Rectum|Severe Dysplasia of the Rectum|Severe Rectal Dysplasia|Stage 0 Carcinoma of Rectum|Stage 0 Carcinoma of the Rectum|Stage 0 Rectal Carcinoma	Stage 0 includes: (Tis, N0, M0).  Tis: Carcinoma in situ: intraepithelial or invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.)-2003
C4854	Abnormal_Urine_Cytology	Abnormal_Urine_Test_Result	Abnormal Urine Cytology|Urine Cytology Atypical
C4855	Laryngeal_Carcinoma	Common_Carcinoma|Malignant_Laryngeal_Neoplasm|Throat_Cancer	Laryngeal Carcinoma|Cancer of Larynx|Cancer of the Larynx|Carcinoma of Larynx|Carcinoma of the Larynx|Laryngeal Cancer|Larynx Carcinoma	Carcinoma that arises from the laryngeal epithelium.  More than 90% of laryngeal carcinomas are squamous cell carcinomas.  The remainder are adenoid cystic carcinomas, mucoepidermoid carcinomas and carcinomas with neuroendocrine differentiation. --2002
C4856	Adrenal_Medulla_Neoplasm	Adrenal_Gland_Neoplasm	Adrenal Medulla Neoplasm|Adrenal Medulla Tumor	A benign or malignant (primary or metastatic) neoplasm affecting the adrenal medulla. (NCI05)
C4858	Placental_Neoplasm	Female_Reproductive_System_Neoplasm|Placenta_Disorder	Placental Neoplasm|Neoplasm of Placenta|Neoplasm of the Placenta|Placenta Neoplasm|Placenta Neoplasms|Placenta Tumor|Placenta Tumors|Placental Tumor|Placental Tumors|Tumor of Placenta|Tumor of the Placenta	A neoplasm involving the cells of the placenta
C4859	Hybrid_Resistance	Immune_System_Disorder	Hybrid Resistance
C4860	Lung_Sarcoma	Lung_Soft_Tissue_Neoplasm|Malignant_Lung_Neoplasm	Lung Sarcoma|Pulmonary Sarcoma|Sarcoma of Lung|Sarcoma of the Lung
C4861	Monocytic_Leukemia	Acute_Monoblastic_Leukemia_and_Acute_Monocytic_Leukemia	Acute Monocytic Leukemia|Acute Monocytic Leukemia (FAB M5b)|Monocytic Leukemia	An acute myeloid leukemia in which the majority of monocytic cells are promonocytes.  (WHO, 2001) -- 2003
C4862	Ovarian_Sex_Cord-Stromal_Tumor	Infrequent_Neoplasm|Ovarian_Neoplasm|Sex_Cord-Stromal_Tumor	Ovarian Sex Cord-Stromal Tumor|Ovarian Sex Cord-Stromal Neoplasm|Sex Cord-Stromal Neoplasm of Ovary|Sex Cord-Stromal Neoplasm of the Ovary|Sex Cord-Stromal Tumor of Ovary|Sex Cord-Stromal Tumor of the Ovary	Sex cord-stromal tumors comprise about 5% of all ovarian neoplasms.
C4863	Prostate_Carcinoma	Carcinoma|Malignant_Prostate_Neoplasm	Prostate Carcinoma|Cancer of Prostate|Cancer of the Prostate|Carcinoma of Prostate|Carcinoma of the Prostate|Prostate Cancer	One of the most common malignant tumors afflicting men.  The majority of carcinomas arise in the peripheral zone and a minority occur in the central or the transitional zone of the prostate gland.  Grossly, prostatic carcinomas appear as ill-defined yellow areas of discoloration in the prostate gland lobes.  Adenocarcinomas represent the overwhelming majority of prostatic carcinomas.  Prostatic-specific antigen (PSA) serum test is widely used as a screening test for the early detection of prostatic carcinoma.  Treatment options include radical prostatectomy, radiation therapy, androgen ablation and cryotherapy.  Watchful waiting or surveillance alone is an option for older patients with low-grade or low-stage disease.  -- 2002
C4865	Dental_Granuloma	Foreign_Body_Granuloma	Dental Granuloma
C4866	Vulvar_Carcinoma	Carcinoma|Malignant_Vulvar_Neoplasm	Vulvar Carcinoma|Cancer of Vulva|Cancer of the Vulva|Carcinoma of Vulva|Carcinoma of the Vulva|Vulva Cancer|Vulva Carcinoma|Vulvar Cancer|vulvar cancer	Cancer of the vulva (the external female genital organs, including the clitoris, vaginal lips, and the opening to the vagina).
C4867	Malignant_Soft_Tissue_Neoplasm	Soft_Tissue_Neoplasm	Malignant Soft Tissue Neoplasm|Malignant Neoplasm of Soft Tissue|Malignant Neoplasm of the Soft Tissue|Malignant Soft Tissue Tumor|Malignant Tumor of Soft Tissue|Malignant Tumor of the Soft Tissue	Abnormal growth of the cells comprising the soft tissue, excluding metastatic tumors that arise in the soft tissue. This concept specifically refers to tumors with malignant characteristics.
C4868	Placental_Hemangioma	Benign_Placental_Neoplasm|Hemangioma	Placental Hemangioma|Angioma of Placenta|Angioma of the Placenta|Chorioangioma|Hemangioma of Placenta|Hemangioma of the Placenta|Placental Angioma
C4869	Brain_Stem_Neoplasm	Infratentorial_Neoplasm	Brain Stem Neoplasm|Brain Stem Neoplasms|Brain Stem Tumor|Brainstem Neoplasm|Brainstem Tumor|Neoplasm of Brain Stem|Neoplasm of Brainstem|Neoplasm of the Brain Stem|Neoplasm of the Brainstem|Tumor of Brain Stem|Tumor of Brainstem|Tumor of the Brain Stem|Tumor of the Brainstem|brain stem tumor	A tumor in the part of the brain that connects to the spinal cord (the brain stem).
C4870	Complete_Remission	Remission	Complete Remission|CR|complete remission|complete response	The disappearance of all signs of cancer in response to treatment.  This does not always mean the cancer has been cured.
C4871	Complete_Hydatidiform_Mole	Hydatidiform_Mole	Complete Hydatidiform Mole|Complete Hydatid Mole|Complete Molar Pregnancy|Complete Mole
C4872	Breast_Carcinoma	Carcinoma|Common_Carcinoma|Malignant_Breast_Neoplasm	Breast Carcinoma|Breast Cancer|Cancer of Breast|Cancer of the Breast|Carcinoma of Breast|Carcinoma of the Breast|Mammary Carcinoma
C4873	Rare_Disorder	Diseases_and_Disorders	Rare Disorder|Rare Disease|Rare Diseases	A non-malignant disease that affects fewer than 200,000 people in the United States. (from National Organization for Rare Disorders)
C4874	Cerebral_Neoplasm	Supratentorial_Neoplasm	Cerebral Neoplasm|Cerebral Hemispheric Neoplasm|Cerebral Hemispheric Tumor|Cerebral Neoplasms|Cerebral Tumor|Neoplasm of Cerebral Hemispheres|Neoplasm of Cerebrum|Neoplasm of the Cerebral Hemispheres|Neoplasm of the Cerebrum|Tumor of Cerebral Hemispheres|Tumor of Cerebrum|Tumor of the Cerebral Hemispheres|Tumor of the Cerebrum
C4875	Reproductive_System_Disorder	Disorder_by_Site	Reproductive System Disorder|Genital Disorders|Reproductive System Disease
C4876	Symptom	Other_Finding	Symptom|SM|Symptoms|symptom	An indication that a person has a condition or disease.  Some examples of symptoms are headache, fever, fatigue, nausea, vomiting, and pain.
C4877	Rectosigmoid_Neoplasm	Colorectal_Neoplasm	Rectosigmoid Neoplasm|Neoplasm of Rectosigmoid Junction|Neoplasm of the Rectosigmoid Junction|Rectosigmoid Tumor|Tumor of Rectosigmoid Junction|Tumor of the Rectosigmoid Junction
C4878	Lung_Carcinoma	Carcinoma|Malignant_Lung_Neoplasm	Lung Carcinoma|Cancer of Lung|Cancer of the Lung|Carcinoma of Lung|Carcinoma of the Lung|Lung Cancer	A carcinoma originating in the lung.  Lung carcinomas usually arise from the epithelium that lines the bronchial tree (bronchogenic carcinomas), and are classified as small cell or non-small cell carcinomas.  Non-small cell lung carcinomas are usually adenocarcinomas, squamous cell carcinomas, or large cell carcinomas.  Metastatic carcinomas to the lung are also common, and can be difficult to distinguish from primary tumors. -- 2004
C4879	Benign_Sweat_Gland_Neoplasm	Benign_Skin_Appendage_Neoplasm|Sweat_Gland_Neoplasm	Benign Sweat Gland Neoplasm|Benign Neoplasm of Sweat Gland|Benign Neoplasm of the Sweat Gland|Benign Sweat Gland Tumor|Benign Tumor of Sweat Gland|Benign Tumor of the Sweat Gland|Sweat Gland Neoplasm, Benign
C4880	Benign_Bone_Neoplasm	Benign_Mesenchymal_Cell_Neoplasm|Bone_Neoplasm	Benign Bone Neoplasm|Benign Bone Tumor|Benign Neoplasm of Bone|Benign Neoplasm of the Bone|Benign Osseous Neoplasm|Benign Osseous Tumor|Benign Tumor of Bone|Benign Tumor of the Bone
C4881	Metastatic_Neoplasm_to_the_Spine	Metastatic_Neoplasm_to_the_Bone	Metastatic Malignant Neoplasm to the Spine|Metastases to Spine|Metastases to the Spine|Metastasis to Spine|Metastasis to the Spine|Metastatic Cancer to the Spine|Metastatic Cancer to the Vertebral Column|Metastatic Neoplasm to the Spine|Metastatic Neoplasm to the Vertebral Column|Metastatic Tumor to the Spine|Metastatic Tumor to the Vertebral Column	The spread of the cancer to the spine.  This may be from a primary spinal cancer, or from a cancer at a distant site.
C4882	Benign_Muscle_Neoplasm	Benign_Soft_Tissue_Neoplasm|Myomatous_Neoplasm	Benign Muscle Neoplasm|Benign Muscle Tumor|Benign Neoplasm of Muscle|Benign Neoplasm of the Muscle|Benign Tumor of Muscle|Benign Tumor of the Muscle|Myoma
C4883	Malignant_Muscle_Neoplasm	Myomatous_Neoplasm	Malignant Muscle Neoplasm|Malignant Muscle Tumor|Malignant Neoplasm of Muscle|Malignant Neoplasm of the Muscle|Malignant Tumor of Muscle|Malignant Tumor of the Muscle|Myosarcoma
C4884	Benign_Neck_Neoplasm	Neck_Neoplasm	Benign Neck Neoplasm|Benign Neck Tumor|Benign Neoplasm of Neck|Benign Neoplasm of the Neck|Benign Tumor of Neck|Benign Tumor of the Neck
C4886	Benign_Pyriform_Fossa_Neoplasm	Benign_Hypopharyngeal_Neoplasm|Pyriform_Fossa_Neoplasm	Benign Pyriform Fossa Neoplasm|Benign Neoplasm of Pyriform Fossa|Benign Neoplasm of Pyriform Sinus|Benign Neoplasm of the Pyriform Fossa|Benign Neoplasm of the Pyriform Sinus|Benign Pyriform Fossa Tumor|Benign Pyriform Sinus Neoplasm|Benign Pyriform Sinus Tumor|Benign Tumor of Pyriform Fossa|Benign Tumor of Pyriform Sinus|Benign Tumor of the Pyriform Fossa|Benign Tumor of the Pyriform Sinus
C4887	Metastatic_Neoplasm_to_the_Trachea	Metastatic_Neoplasm_to_the_Neck	Metastatic Malignant Neoplasm to the Trachea|Metastasis to the Trachea|Metastatic Neoplasm to the Trachea|Metastatic Tumor to the Trachea|Secondary Malignant Neoplasm to the Trachea|Secondary Malignant Tumor to the Trachea
C4888	Benign_Lung_Hilum_Neoplasm	Benign_Lung_Neoplasm|Lung_Hilum_Neoplasm	Benign Lung Hilum Neoplasm|Benign Hilar Lung Neoplasm|Benign Hilar Lung Tumor|Benign Lung Hilum Tumor
C4889	Metastatic_Neoplasm_to_the_Heart	Malignant_Cardiac_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Heart|Metastases to Heart|Metastases to the Heart|Metastasis to Heart|Metastasis to the Heart|Metastatic Neoplasm to the Heart|Metastatic Tumor to the Heart
C4890	Malignant_Gastrointestinal_Neoplasm	Gastrointestinal_Neoplasm	Malignant Gastrointestinal Neoplasm|Gastrointestinal Tract Cancer	A primary or metastatic malignant tumor involving any part of the gastrointestinal tract. -- 2003
C4891	Benign_Submandibular_Gland_Neoplasm	Benign_Major_Salivary_Gland_Neoplasm|Submandibular_Gland_Neoplasm	Benign Submandibular Gland Neoplasm|Benign Neoplasm of Submandibular Gland|Benign Neoplasm of the Submandibular Gland|Benign Submandibular Gland Tumor|Benign Tumor of Submandibular Gland|Benign Tumor of the Submandibular Gland
C4892	Stage_0_Small_Intestinal_Cancer	Grade_III_Glandular_Intraepithelial_Neoplasia|Small_Intestinal_Carcinoma|Small_Intestinal_High-Grade_Intraepithelial_Neoplasia	Stage 0 Small Intestinal Cancer|Small Intestine Cancer Stage 0|Small Intestine Carcinoma in situ|Stage 0 Small Intestine Carcinoma
C4893	Benign_Urinary_Tract_Neoplasm	Urinary_Tract_Neoplasm	Benign Urinary Tract Neoplasm|Benign Neoplasm of Urinary Tract|Benign Neoplasm of the Urinary Tract|Benign Tumor of Urinary Tract|Benign Tumor of the Urinary Tract|Benign Urinary Tract Tumor
C4894	Benign_Endometrial_Neoplasm	Benign_Uterine_Corpus_Neoplasm|Endometrial_Neoplasm	Benign Endometrial Neoplasm|Benign Endometrial Tumor|Benign Endometrium Neoplasm|Benign Endometrium Tumor|Benign Neoplasm of Endometrium|Benign Neoplasm of the Endometrium|Benign Tumor of Endometrium|Benign Tumor of the Endometrium
C4895	Benign_Adrenal_Medulla_Neoplasm	Adrenal_Medulla_Neoplasm|Benign_Adrenal_Gland_Neoplasm	Benign Adrenal Medulla Neoplasm|Benign Adrenal Medulla Tumor|Benign Neoplasm of Adrenal Medulla|Benign Neoplasm of the Adrenal Medulla|Benign Tumor of Adrenal Medulla|Benign Tumor of the Adrenal Medulla	A non-metastasizing neoplasm arising from the adrenal medulla. (NCI05)
C4896	Leukemia_in_Remission	Hematologic_Disorder	Leukemia in Remission|Leukemia (in Remission)	History of leukemia after therapy with no evidence on the peripheral blood or bone marrow of leukemia (normalization of all hematologic parameters).
C4897	Acute_Leukemia_in_Remission	Leukemia_in_Remission	Acute Leukemia in Remission|Acute Leukemia (in Remission)	Acute leukemia not growing; responding to treatment
C4898	Chronic_Leukemia_in_Remission	Leukemia_in_Remission	Chronic Leukemia in Remission|Chronic Leukemia (in Remission)	Leukemia that is no longer growing or metastasizing; it is responding to therapy.
C4899	Myeloid_Leukemia_in_Remission	Leukemia_in_Remission	Myeloid Leukemia in Remission|Myelocytic Leukemia in Remission|Myelogenous Leukemia in Remission	Granulocytic leukemia, remission.  1. Abatement or lessening in severity of the symptoms of a disease. 2. The period during which such abatement occurs.
C4900	Monocytic_Leukemia_in_Remission	Retired_Concepts	Monocytic Leukemia in Remission|Monocytic Leukemia (in Remission)	Monocytic leukemia responding to treatment and not proliferating
C4901	Lymphoid_Leukemia_in_Remission	Leukemia_in_Remission	Lymphoid Leukemia in Remission|Lymphoid Leukemia (in Remission)	The abatement of lymphoid leukemia, response to therapy.
C4902	Benign_Splenic_Neoplasm	Splenic_Neoplasm	Benign Splenic Neoplasm|Benign Neoplasm of Spleen|Benign Neoplasm of the Spleen
C4903	Metastatic_Neoplasm_to_the_Thymus	Malignant_Thymus_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Thymus|Metastasis to the Thymus|Metastatic Malignant Tumor to the Thymus|Metastatic Neoplasm to the Thymus|Metastatic Tumor to the Thymus|Secondary Malignant Neoplasm to the Thymus|Secondary Malignant Tumor to the Thymus
C4904	Metastatic_Neoplasm_to_Lymph_Nodes	Malignant_Lymph_Node_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Lymph Node|Metastases to Lymph Nodes|Metastasis to Lymph Node|Metastatic Neoplasm to the Lymph Node|Metastatic Tumor to Lymph Node	The spread of cancer to and establishment in the lymph nodes
C4905	Hemangioma_of_the_Skin	Benign_Cutaneous_Vascular_Neoplasm|Hemangioma	Hemangioma of the Skin|Angioma of Skin|Angioma of the Skin|Hemangioma of Skin|Skin Angioma
C4906	Parathyroid_Carcinoma	Adenocarcinoma|Malignant_Endocrine_Neoplasm|Malignant_Parathyroid_Neoplasm|Neck_Carcinoma	Parathyroid Gland Carcinoma|Adenocarcinoma of Parathyroid|Adenocarcinoma of Parathyroid Gland|Adenocarcinoma of the Parathyroid|Adenocarcinoma of the Parathyroid Gland|Cancer of Parathyroid Gland|Cancer of the Parathyroid Gland|Carcinoma of Parathyroid|Carcinoma of Parathyroid Gland|Carcinoma of the Parathyroid|Carcinoma of the Parathyroid Gland|Parathyroid Adenocarcinoma|Parathyroid Cancer|Parathyroid Carcinoma|Parathyroid Gland Adenocarcinoma	A malignant tumor arising from the parenchymal cells of the parathyroid gland.  It is associated with the symptoms of primary hyperparathyroidism, resulting from the excessive production of parathyroid hormone.  Morphologically, the differential diagnosis from parathyroid gland adenoma may be difficult.  A definitive diagnosis of carcinoma is made only in the presence of capsular invasion, vascular invasion, and/or perineural invasion.  (NCI05)
C4907	Hypertensive_Cardiomegaly	Non-Neoplastic_Heart_Disorder	Hypertensive Cardiomegaly
C4908	Ovarian_Carcinoma	Carcinoma|Malignant_Ovarian_Surface_Epithelial_Stromal_Tumor	Ovarian Carcinoma|Carcinoma of Ovary|Carcinoma of the Ovary|Epithelial Ovarian Cancer|epithelial ovarian cancer|ovarian epithelial cancer	(ep-ih-THEE-lee-ul) Cancer that occurs in the cells lining the ovaries.
C4909	Cerebral_Edema	Edema	Cerebral Edema|edema, cerebral
C4910	Colon_Carcinoma	Colorectal_Carcinoma|Malignant_Colon_Neoplasm	Colon Carcinoma|Carcinoma of Colon|Carcinoma of the Colon|Colon Cancer|Colonic Carcinoma|colon cancer	A disease in which malignant (cancer) cells are found in the tissues of the colon.
C4911	Gastric_Carcinoma	Carcinoma|Malignant_Gastric_Neoplasm	Gastric Carcinoma|Cancer of Stomach|Cancer of the Stomach|Carcinoma of Stomach|Carcinoma of the Stomach|Gastric Cancer|Stomach Cancer|Stomach Carcinoma	A malignant epithelial tumor of the stomach mucosa.  The vast majority of gastric carcinomas are adenocarcinomas, arising from the gastric glandular epithelium. --2002
C4912	Bladder_Carcinoma	Carcinoma|Malignant_Bladder_Neoplasm	Bladder Carcinoma|Bladder Cancer|Cancer of Bladder|Cancer of Urinary Bladder|Cancer of the Bladder|Cancer of the Urinary Bladder|Carcinoma of Bladder|Carcinoma of Urinary Bladder|Carcinoma of the Bladder|Carcinoma of the Urinary Bladder|Urinary Bladder Cancer|Urinary Bladder Carcinoma	Bladder carcinoma is a carcinoma arising from the bladder epithelium.  Approximately 90% of the bladder carcinomas are transitional cell carcinomas.  The remainder are squamous cell carcinomas, adenocarcinomas and small cell neuroendocrine carcinomas. --2002
C4913	Malignant_Female_Reproductive_System_Neoplasm	Female_Reproductive_System_Neoplasm|Malignant_Reproductive_System_Neoplasm	Malignant Female Reproductive System Neoplasm|Female Reproductive Cancer|Gynecologic Cancer|Malignant Female Reproductive System Tumor|Malignant Gynecologic Neoplasm|Malignant Gynecologic Tumor|Malignant Neoplasm of Female Reproductive System|Malignant Neoplasm of the Female Reproductive System|Malignant Tumor of Female Reproductive System|Malignant Tumor of the Female Reproductive System|gynecologic cancer	(guy-neh-ko-LAH-jik) Cancer of the female reproductive tract, including the cervix, endometrium, fallopian tubes, ovaries, uterus, and vagina.
C4914	Skin_Carcinoma	Carcinoma|Epithelial_Skin_Neoplasm|Malignant_Skin_Neoplasm	Skin Carcinoma|Carcinoma of Skin|Carcinoma of the Skin|Non-Melanoma Cancer of Skin|Non-Melanoma Cancer of the Skin|Non-Melanoma Skin Cancer|Skin Cancer, Non-Melanoma|nonmelanoma skin cancer	Skin cancer that arises in basal cells or squamous cells but not in melanocytes (pigment-producing cells of the skin).
C4915	Ependymoblastoma	Central_Nervous_System_Primitive_Neuroectodermal_Tumor	Ependymoblastoma
C4916	Focal_Nodular_Hyperplasia_of_the_Liver	Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Hepatic_Disorder	Focal Nodular Hyperplasia of the Liver|Focal Nodular Hyperplasia of Liver
C4917	Small_Cell_Lung_Carcinoma	High_Grade_Lung_Neuroendocrine_Neoplasm|Lung_Carcinoma|Small_Cell_Carcinoma	Small Cell Lung Carcinoma|Lung Oat Cell Carcinoma|Lung Small Cell Neuroendocrine Carcinoma|Oat Cell Carcinoma of Lung|Oat Cell Carcinoma of the Lung|Oat Cell Lung Carcinoma|SCLC|Small Cell Carcinoma of Lung|Small Cell Carcinoma of the Lung|Small Cell Lung Cancer|Small Cell Neuroendocrine Carcinoma of Lung|Small Cell Neuroendocrine Carcinoma of the Lung|small cell lung cancer	A highly aggressive subtype of lung carcinoma characterized by the presence of malignant small cells and necrosis. Metastatic disease is usually present at the time of diagnosis. (NCI05)
C4918	Malignant_Nasal_Cavity_Neoplasm	Nasal_Cavity_Neoplasm	Malignant Nasal Cavity Neoplasm|Malignant Nasal Cavity Tumor|Malignant Neoplasm of Nasal Cavity|Malignant Neoplasm of the Nasal Cavity|Malignant Tumor of Nasal Cavity|Malignant Tumor of the Nasal Cavity
C4919	Rectal_Villous_Adenoma	Colorectal_Villous_Adenoma|Rectal_Adenoma	Rectal Villous Adenoma|Villous Adenoma of Rectum|Villous Adenoma of the Rectum
C4920	Retinal_Capillary_Hemangioma	Capillary_Hemangioma|Retinal_Hemangioma	Retinal Capillary Hemangioma|Capillary Angioma of Retina|Capillary Angioma of the Retina|Capillary Hemangioma of Retina|Capillary Hemangioma of the Retina|Retinal Capillary Angioma
C4921	Retinal_Cavernous_Hemangioma	Cavernous_Hemangioma|Retinal_Hemangioma	Retinal Cavernous Hemangioma|Cavernous Angioma of Retina|Cavernous Angioma of the Retina|Cavernous Hemangioma of Retina|Cavernous Hemangioma of the Retina|Retina Cavernous Angioma|Retina Cavernous Hemangioma|Retinal Cavernous Angioma
C4922	Diverticulosis	Other_Finding	Diverticulosis|Diverticular Disorder|diverticulosis	A condition marked by small sacs or pouches (diverticula) in the walls of an organ such as the stomach or colon. These sacs can become inflamed and cause a condition called diverticulitis, which may be a risk factor for certain types of cancer.
C4923	Glottis_Carcinoma	Laryngeal_Carcinoma|Malignant_Glottis_Neoplasm	Glottis Carcinoma|Cancer of Glottis|Cancer of the Glottis|Carcinoma of Glottis|Carcinoma of the Glottis|Glottic Carcinoma|Glottis Cancer
C4924	Trichothiodystrophy	Genetic_Disorder	Trichothiodystrophy|trichothiodystrophy	A hereditary condition characterized by sparse and brittle hair, short stature, and mental retardation.
C4925	Malignant_Germ_Cell_Neoplasm	Germ_Cell_Neoplasm	Malignant Germ Cell Tumor|Malignant Germ Cell Neoplasm|Malignant Neoplasm of Germ Cell|Malignant Neoplasm of the Germ Cell|Malignant Tumor of Germ Cell|Malignant Tumor of the Germ Cell	Malignant growth of the germ cells in testicular tissue (from PDQ)
C4926	Metastatic_Malignant_Fibrous_Histiocytoma	Malignant_Fibrous_Histiocytoma	Metastatic Malignant Fibrous Histiocytoma|Malignant Fibrous Histiocytoma Metastatic	Malignant neoplasms of fibrous histiocytoma that have metastasized to a secondary site
C4927	Benign_Ovarian_Cyst	Ovarian_Cyst	Benign Ovarian Cyst|Benign Cyst of Ovary|Benign Cyst of the Ovary
C4928	Acute_Respiratory_Distress_Syndrome	Acute_Respiratory_Failure|Respiratory_Distress_Syndrome	Acute Respiratory Distress Syndrome|ARDS	NIH: Respiratory distress of any etiology, excluding neonatal respiratory distress syndrome.
C4929	Chest_Wall_Neoplasm	Chest_Wall_Disorder|Thoracic_Neoplasm	Chest Wall Neoplasm|Chest Wall Tumor|Neoplasm of Chest Wall|Neoplasm of the Chest Wall|Tumor of Chest Wall|Tumor of the Chest Wall
C4930	Colon_Hyperplastic_Polyp	Colorectal_Hyperplastic_Polyp	Colon Hyperplastic Polyp|Colonic Hyperplastic Polyp|Hyperplastic Colonic Polyp|Hyperplastic Polyp of Colon|Hyperplastic Polyp of the Colon|Metaplastic Colon Polyp|Metaplastic Colonic Polyp|Metaplastic Polyp of Colon|Metaplastic Polyp of the Colon
C4932	Duodenal_Adenoma	Duodenal_Neoplasm|Small_Intestinal_Adenoma	Duodenal Adenoma
C4933	Epiglottis_Neoplasm	Supraglottis_Neoplasm	Epiglottis Neoplasm|Epiglottic Neoplasm|Epiglottic Tumor|Epiglottis Tumor|Neoplasm of Epiglottis|Neoplasm of the Epiglottis|Tumor of Epiglottis|Tumor of the Epiglottis
C4934	Benign_Female_Reproductive_System_Neoplasm	Benign_Reproductive_System_Neoplasm|Female_Reproductive_System_Neoplasm	Benign Female Reproductive System Neoplasm|Benign Female Reproductive System Tumor|Benign Gynecologic Neoplasm|Benign Gynecologic Tumor	Abnormal growth of the cells that comprise the organs of the female reproductive tract. This concept refers to growths without malignant characteristics.
C4935	Ileal_Carcinoid_Tumor	Ileal_Neoplasm|Midgut_Carcinoid_Tumor|Small_Intestinal_Carcinoid_Tumor	Ileal Carcinoid Tumor|Carcinoid Neoplasm of Ileum|Carcinoid Neoplasm of the Ileum|Carcinoid Tumor of Ileum|Carcinoid Tumor of the Ileum|Ileal Carcinoid Neoplasm
C4936	Hepatic_Granuloma	Granuloma_by_Site	Hepatic Granuloma|Liver Granuloma
C4937	Recurrent_Hodgkin_s_Lymphoma	Hodgkin_s_Lymphoma|Relapsed_Hematologic_Malignancy	Recurrent Hodgkin's Lymphoma|Recurrent Hodgkin's Disease|Recurrent Hodgkins Disease|Recurrent Hodgkins Lymphoma
C4938	Localized_Lymphoma	Lymphoma	Localized Lymphoma
C4939	Benign_Lymphoproliferative_Disorder	Lymphoproliferative_Disorder|Non-Neoplastic_Hematologic_Disorder	Benign Lymphoproliferative Disorder
C4940	Malignant_Neck_Neoplasm	Neck_Neoplasm	Malignant Neck Neoplasm|Cancer of Neck|Cancer of the Neck|Malignant Neck Tumor|Malignant Neoplasm of Neck|Malignant Neoplasm of the Neck|Malignant Tumor of Neck|Malignant Tumor of the Neck|Neck Cancer
C4941	Soft_Palate_Squamous_Cell_Carcinoma	Palate_Squamous_Cell_Carcinoma|Soft_Palate_Carcinoma	Soft Palate Squamous Cell Carcinoma|SCC of Soft Palate|SCC of the Soft Palate|Soft Palate SCC|Squamous Cell Carcinoma of Soft Palate|Squamous Cell Carcinoma of the Soft Palate
C4942	Stage_0_Pharyngeal_Cancer	Carcinoma_in_situ|Pharyngeal_Carcinoma	Stage 0 Pharyngeal Cancer|Carcinoma in situ of Pharynx|Carcinoma in situ of the Pharynx|Pharyngeal Cancer Stage 0|Pharyngeal Carcinoma in situ|Pharynx Carcinoma in situ|Stage 0 Carcinoma of Pharynx|Stage 0 Carcinoma of the Pharynx|Stage 0 Pharyngeal Carcinoma|Stage 0 Pharynx Carcinoma
C4943	Pyriform_Fossa_Squamous_Cell_Carcinoma	Hypopharyngeal_Squamous_Cell_Carcinoma|Pyriform_Fossa_Carcinoma	Pyriform Fossa Squamous Cell Carcinoma|Epidermoid Carcinoma of Pyriform Fossa|Epidermoid Carcinoma of Pyriform Sinus|Epidermoid Carcinoma of the Pyriform Fossa|Epidermoid Carcinoma of the Pyriform Sinus|Pyriform Fossa Epidermoid Carcinoma|Pyriform Sinus Epidermoid Carcinoma|Pyriform Sinus Squamous Cell Carcinoma|Squamous Cell Carcinoma of Pyriform Fossa|Squamous Cell Carcinoma of Pyriform Sinus|Squamous Cell Carcinoma of the Pyriform Fossa|Squamous Cell Carcinoma of the Pyriform Sinus
C4944	Sella_Turcica_Neoplasm	Skull_Base_Neoplasm	Sella Turcica Neoplasm|Neoplasm of Sella Turcica|Neoplasm of the Sella Turcica|Sella Turcica Tumor|Sellar Neoplasm|Sellar Tumor|Tumor of Sella Turcica|Tumor of the Sella Turcica	A variety of neoplasms arising from the skull base may affect the CNS, mainly by expansion, causing optic nerve and hypothalamic symptoms. Most frequent are pituitary adenomas, which are traditionally not grouped together with CNS tumors. Other, less frequent lesions in this region include granular cell tumors of the pituitary stalk and chordomas. Craniopharyngiomas area also included in this group. (Adapted from WHO.)
C4945	Supraglottic_Squamous_Cell_Carcinoma	Laryngeal_Squamous_Cell_Carcinoma|Supraglottic_Carcinoma	Supraglottic Squamous Cell Carcinoma|Epidermoid Carcinoma of Supraglottis|Epidermoid Carcinoma of the Supraglottis|Squamous Cell Carcinoma of Supraglottis|Squamous Cell Carcinoma of the Supraglottis|Supraglottic Epidermoid Carcinoma|Supraglottis Epidermoid Carcinoma|Supraglottis Squamous Cell Carcinoma
C4946	Thyroid_Hurthle_Cell_Carcinoma	Follicular_Thyroid_Carcinoma|Thyroid_Gland_Oncocytic_Neoplasm	Thyroid Gland Oncocytic Follicular Carcinoma|Hurthle Cell Carcinoma of Thyroid|Hurthle Cell Carcinoma of Thyroid Gland|Hurthle Cell Carcinoma of the Thyroid|Hurthle Cell Carcinoma of the Thyroid Gland|Hurthle Cell Thyroid Gland Carcinoma|Oncocytic Carcinoma of Thyroid|Oncocytic Carcinoma of the Thyroid|Thyroid Gland Hurthle Cell Carcinoma|Thyroid Hurthle Cell Carcinoma|Thyroid Oncocytic Carcinoma	A follicular carcinoma of the thyroid gland, characterized by the presence of large cells with eosinophilic granular cytoplasm and pleomorphic nuclei with prominent, eosinophilic nucleoli.  The nuclear features that characterize the papillary carcinomas of the thyroid gland are absent. (NCI05)
C4947	Vaginal_Condyloma_Acuminatum	Condyloma_Acuminatum|Vaginal_Squamous_Neoplasm	Vaginal Condyloma Acuminatum|Condylomata Acuminata of Vagina|Condylomata Acuminata of the Vagina|Vaginal Condyloma
C4948	Vaginal_Fibroepithelial_Polyp	Fibroepithelial_Polyp|Vaginal_Polyp	Vaginal Fibroepithelial Polyp|Fibroepithelial Polyp of Vagina|Fibroepithelial Polyp of the Vagina|Vaginal Fibroepithelial Stromal Polyp
C4949	Hepatic_Lymphoma	Gastrointestinal_Lymphoma|Hepatic_Disorder|Malignant_Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm	Hepatic Lymphoma|Liver Lymphoma|Lymphoma of Liver|Lymphoma of the Liver|Primary Hepatic Lymphoma
C4950	Colon_Non-Hodgkin_s_Lymphoma	Colon_Lymphoma|Gastrointestinal_Non-Hodgkin_s_Lymphoma	Colon Non-Hodgkin's Lymphoma|Colon Non-Hodgkin Lymphoma|Colon NonHodgkin's Lymphoma|Colonic Non-Hodgkin's Lymphoma|Colonic NonHodgkin's Lymphoma|Non-Hodgkin's Lymphoma of Colon|Non-Hodgkin's Lymphoma of the Colon|Primary Colon Non-Hodgkin's Lymphoma
C4951	Cerebral_Astrocytoma	Astrocytic_Tumor|Cerebral_Neoplasm	Cerebral Astrocytoma|Astrocytic Neoplasm of Cerebral Hemispheres|Astrocytic Neoplasm of Cerebrum|Astrocytic Neoplasm of the Cerebral Hemispheres|Astrocytic Neoplasm of the Cerebrum|Astrocytic Tumor of Cerebral Hemispheres|Astrocytic Tumor of Cerebrum|Astrocytic Tumor of the Cerebral Hemispheres|Astrocytic Tumor of the Cerebrum|Astrocytoma of Cerebral Hemispheres|Astrocytoma of Cerebrum|Astrocytoma of the Cerebral Hemispheres|Astrocytoma of the Cerebrum|Cerebral Astrocytic Neoplasm|Cerebral Astrocytic Tumor|Cerebral Hemispheric Astrocytic Neoplasm|Cerebral Hemispheric Astrocytic Tumor|Cerebral Hemispheric Astrocytoma
C4952	Primary_Brain_Neoplasm	Brain_Neoplasm	Primary Brain Neoplasm|Primary Brain Tumor
C4953	Intracranial_Neoplasm	Central_Nervous_System_Neoplasm	Intracranial Neoplasm|Intracranial Central Nervous System Neoplasms|Intracranial Central Nervous System Tumors|Intracranial Tumor|Intracranial Tumors|intracranial tumors	Benign and malignant neoplasms that arise from or metastasize to structures within the cranium.  This includes meningeal and other tumors that occur in the spaces that surround the brain, and neoplasms of the brain.  (KEV 8-9-99)
C4954	Malignant_Primary_Brain_Neoplasm	Malignant_Brain_Neoplasm|Primary_Brain_Neoplasm	Malignant Primary Brain Neoplasm|Malignant Primary Brain Tumor
C4955	Benign_Cerebellar_Neoplasm	Benign_Infratentorial_Neoplasm|Cerebellar_Neoplasm	Benign Cerebellar Neoplasm|Benign Cerebellar Neoplasms|Benign Cerebellar Tumor|Benign Neoplasm of Cerebellum|Benign Neoplasm of the Cerebellum|Benign Tumor of Cerebellum|Benign Tumor of the Cerebellum|Cerebellar Neoplasms, Benign|Neoplasms, Benign, Cerebellar|Neoplasms, Cerebellar, Benign	Non-malignant neoplasms that arise from cerebellar tissue.  During childhood the most common form is pilocytic astrocytoma although fibrillary astrocytomas may also occur.  These tumors may present with slowly progressive signs caused by a slowly expanding mass lesion or acutely due to hemorrhage of a vascular tumor.  Clinical signs and symptoms may include ataxia, nystagmus, spasticity long tract signs, headache, nausea, vomiting, papilledema, diplopia, spasticity, and weakness, etc.) (KEV 8-7-99)
C4956	Desmoplastic_Medulloblastoma	Medulloblastoma	Desmoplastic Medulloblastoma	Desmoplastic Medulloblastoma is a variant of Medulloblastoma. Some histologic features of this lesion include nodular, reticulin-free zones ('pale islands') surrounded by densely packed, highly proliferative cells that produce a dense intercellular reticulin fiber network. (Adapted from WHO.)
C4957	Benign_Neoplasms_of_the_Meninges	Meningeal_Neoplasm	Benign Neoplasms of the Meninges|Benign Meningeal Neoplasm|Benign Meningeal Neoplasms|Benign Meningeal Tumor|Benign Meningeal Tumors|Benign Meninges Neoplasm|Benign Meninges Tumor|Benign Neoplasm of Meninges|Benign Neoplasm of the Meninges|Benign Neoplasms of Meninges|Benign Tumor of Meninges|Benign Tumor of the Meninges|Meningeal Tumors, Benign	A benign tumor occurring in the meninges, which surround the brain and spinal cord.  The most common are meningiomas. - 2004
C4958	Leptomeningeal_Neoplasm	Meningeal_Neoplasm	Leptomeningeal Neoplasm|Leptomeningeal Tumor|Neoplasm of Leptomeninges|Neoplasm of the Leptomeninges|Tumor of Leptomeninges|Tumor of the Leptomeninges
C4959	Cerebral_Convexity_Meningioma	Cerebral_Meningioma	Cerebral Convexity Meningioma|Cerebral Hemispheric Convexity Meningioma
C4960	Parasagittal_Meningioma	Cerebral_Convexity_Meningioma	Parasagittal Meningioma
C4961	Malignant_Peripheral_Nervous_System_Neoplasm	Malignant_Nervous_System_Neoplasm|Peripheral_Nervous_System_Neoplasm	Malignant Peripheral Nervous System Neoplasm|Malignant Neoplasm of PNS|Malignant Neoplasm of Peripheral Nerve|Malignant Neoplasm of Peripheral Nervous System|Malignant Neoplasm of the PNS|Malignant Neoplasm of the Peripheral Nerve|Malignant Neoplasm of the Peripheral Nervous System|Malignant Neoplasms, Peripheral Nerve|Malignant PNS Neoplasm|Malignant PNS Tumor|Malignant Peripheral Nerve Neoplasm|Malignant Peripheral Nerve Tumor|Malignant Peripheral Nervous System Tumor|Malignant Tumor of PNS|Malignant Tumor of Peripheral Nerve|Malignant Tumor of Peripheral Nervous System|Malignant Tumor of the PNS|Malignant Tumor of the Peripheral Nerve|Malignant Tumor of the Peripheral Nervous System|Peripheral Nervous System Neoplasms, Malignant	Malignant growth of cells in the peripheral nervous system (PNS)or Autonomic Nervous System (ANS), without specification as to location
C4962	Malignant_Thymus_Neoplasm	Thymic_Neoplasm	Malignant Thymus Neoplasm|Cancer of Thymus|Cancer of the Thymus|Malignant Neoplasm of Thymus|Malignant Neoplasm of the Thymus|Malignant Thymus Tumor|Malignant Tumor of Thymus|Malignant Tumor of the Thymus|Thymus Cancer	Primary or metastatic malignant neoplasm involving the thymus. This category includes malignant thymomas, thymic lymphomas, primary thymic carcinomas, and metastatic carcinomas from other anatomic sites. --2003
C4963	Benign_Supratentorial_Neoplasm	Benign_Brain_Neoplasm|Supratentorial_Neoplasm	Benign Supratentorial Neoplasm|Benign Supratentorial Neoplasms|Benign Supratentorial Tumor|Benign Supratentorial Tumors|Supratentorial Neoplasms, Benign	Primary neoplasms of the brain which occur above the cerebellar tentorium.  These tumors are noninvasive and tend to grow slowly.  In children, craniopharyngiomas are relatively common.  Fairly frequent adult supratentorial benign tumors include meningiomas and pituitary adenomas.  (KEV 8-14-99)
C4964	Malignant_Supratentorial_Neoplasm	Malignant_Brain_Neoplasm|Supratentorial_Neoplasm	Malignant Supratentorial Neoplasm|Malignant Supratentorial Tumor|Supratentorial Neoplasms, Malignant
C4965	Benign_Infratentorial_Neoplasm	Benign_Brain_Neoplasm|Infratentorial_Neoplasm	Benign Infratentorial Neoplasm|Benign Infratentorial Tumor
C4966	Malignant_Infratentorial_Neoplasm	Infratentorial_Neoplasm|Malignant_Brain_Neoplasm	Malignant Infratentorial Neoplasm|Infratentorial Neoplasms, Malignant|Malignant Infratentorial Tumor|Malignant Infratentorial Tumors	Malignant neoplasms which arise or occur within the intracranial cavity below the tentorium cerebelli.  This includes neoplasms within the brain and/or surrounding spaces.
C4967	Adult_Acute_Lymphoblastic_Leukemia	Acute_Lymphoblastic_Leukemia	Adult Acute Lymphoblastic Leukemia|Adult ALL|Adult Acute Lymphocytic Leukemia|Adult Acute Lymphogenous Leukemia|Adult Acute Lymphoid Leukemia
C4968	Secondary_Malignant_Neoplasm	Malignant_Neoplasm	Secondary Malignant Neoplasm|Secondary Cancer|Secondary Malignancy|Secondary Malignancy (After Treatment of Primary Cancer)|second cancer|secondary cancer	A late complication of cancer therapy, possibly related to treatment modality or to an inherent genetic susceptibility such as mutation in p53. Much of the current data has been derived from patients treated in childhood and/or patients treated for Hodgkins lymphoma.
C4969	Therapy_Related_Malignant_Neoplasm	Therapy-Related_Neoplasm	Therapy Related Malignant Neoplasm|Iatrogenic Cancer|Therapy Related Cancer|Therapy Related Malignant Tumor	The development of a malignant neoplasm in response to medical or surgical treatment, induced by the treatment itself.
C4970	Cerebral_Primitive_Neuroectodermal_Tumor	Malignant_Cerebral_Neoplasm|Supratentorial_Primitive_Neuroectodermal_Tumor	Cerebral Primitive Neuroectodermal Tumor|Cerebral Hemisphere PNET|Cerebral Hemisphere Primitive Neuroectodermal Neoplasm|Cerebral Hemisphere Primitive Neuroectodermal Tumor|Cerebral PNET|Cerebral Primitive Neuroectodermal Neoplasm|PNET of Cerebral Hemispheres|PNET of Cerebrum|PNET of the Cerebral Hemispheres|PNET of the Cerebrum|Primitive Neuroectodermal Neoplasm of Cerebral Hemispheres|Primitive Neuroectodermal Neoplasm of Cerebrum|Primitive Neuroectodermal Neoplasm of the Cerebral Hemispheres|Primitive Neuroectodermal Neoplasm of the Cerebrum|Primitive Neuroectodermal Tumor of Cerebral Hemispheres|Primitive Neuroectodermal Tumor of Cerebrum|Primitive Neuroectodermal Tumor of the Cerebral Hemispheres|Primitive Neuroectodermal Tumor of the Cerebrum
C4971	Malignant_Squamous_Cell_Neoplasm	Squamous_Cell_Neoplasm	Malignant Squamous Cell Neoplasm|Epidermoid Cell Cancer|Malignant Epidermoid Cell Neoplasm|Malignant Epidermoid Cell Tumor|Malignant Squamous Cell Tumor|Squamous Cell Cancer
C4972	Peripheral_Nerve_Sheath_Neoplasm	Neuroepithelial_Perineurial_and_Schwann_Cell_Neoplasm	Nerve Sheath Neoplasm|Neoplasm of Nerve Sheath|Neoplasm of the Nerve Sheath|Nerve Sheath Neoplasms|Nerve Sheath Tumor|Nerve Sheath Tumors|Tumor of Nerve Sheath
C4973	Perineurioma	Peripheral_Nerve_Sheath_Neoplasm	Perineurioma	Perineuriomas (WHO grade I) are rare, benign tumors composed entirely of neoplastic perineurial cells. They can occur intraneurally or as soft tissue lesions.  (Adapted from WHO.)
C4974	Nervous_System_Injury	Injury	Nervous System Injury|Neurological Damage	Injury in the central or peripheral nervous system. -- 2003
C4975	Primary_Brain_Stem_Neoplasm	Brain_Stem_Neoplasm|Primary_Brain_Neoplasm	Primary Brain Stem Neoplasm|Primary Brain Stem Tumor
C4976	Central_Nervous_System_Vascular_Malformation	Congenital_Abnormality	Central Nervous System Vascular Malformation|CNS Vascular Malformation|Vascular Malformation of CNS|Vascular Malformation of the CNS|Vascular Malformations of Central Nervous System|Vascular Malformations of the Central Nervous System
C4977	Rathke_Pouch_Cyst	Central_Nervous_System_Cyst	Rathke Pouch Cyst|Cyst of Rathke's Pouch|Rathke Cleft Cyst|Rathke's Pouch Cyst|Suprasellar Cyst	Rathke's pouch cysts are rarely symptomatic in the first two decades of life though they may produce symptoms in the third and fourth decades of life.  When the cysts do present in the first decades of life, the symptoms are generally associated with diabetes insipidus or other conditions related to hypopituitarism.
C4978	Malignant_Colorectal_Neoplasm	Colorectal_Neoplasm|Malignant_Intestinal_Neoplasm	Malignant Colorectal Neoplasm|Malignant Colorectal Tumor|Malignant Large Bowel Neoplasm|Malignant Large Bowel Tumor|Malignant Large Intestine Neoplasm|Malignant Large Intestine Tumor|Malignant Neoplasm of Large Bowel|Malignant Neoplasm of Large Intestine|Malignant Neoplasm of the Large Bowel|Malignant Neoplasm of the Large Intestine|Malignant Tumor of Large Bowel|Malignant Tumor of Large Intestine|Malignant Tumor of the Large Bowel|Malignant Tumor of the Large Intestine	Malignant tumor of the colon or rectum. The majority are adenocarcinomas.  Loss of imprinting (LOI) of the insulin-like growth factor II (IGF2) gene is suggested to be associated with a predisposition to sporadic colorectal cancer.
C4979	Primary_Carcinoma_Unspecified_Site	Primary_Carcinoma	Primary Carcinoma Unspecified Site
C4980	Acute_Graft_Versus_Host_Disease	Graft_Versus_Host_Disease	Acute Graft Versus Host Disease|Acute GVHD
C4981	Chronic_Graft_Versus_Host_Disease	Graft_Versus_Host_Disease	Chronic Graft Versus Host Disease|Chronic GVHD
C4982	Aleukemic_Leukemia	Leukemia	Aleukemic Leukemia	A leukemia characterised by the absence of leukemic cells in the peripheral blood. -- 2003
C4983	Aleukemic_Leukemia_Cutis	Aleukemic_Leukemia	Aleukemic Leukemia Cutis
C4984	Ovarian_Neoplasm	Female_Reproductive_System_Neoplasm|Ovarian_Disorder	Ovarian Neoplasm|Neoplasm of Ovary|Neoplasm of the Ovary|Ovarian Tumor|Ovarian Tumors|Tumor of Ovary|Tumor of the Ovary	Having to do with the ovaries, the female reproductive glands in which the ova (eggs) are formed. The ovaries are located in the pelvis, one on each side of the uterus.
C4985	Oropharyngeal_Candidiasis	Candidiasis	Oropharyngeal Candidiasis	Infection of the oropharynx with, or disease caused by, Candida, especially C. albicans. This disease usually results from debilitation (as in immunosuppression and especially AIDS), physiologic change, prolonged administration of antibiotics, and iatrogenic and barrier breakage. SYN candidosis, moniliasis.
C4987	AIDS_in_Hemophiliac_Population	AIDS_Treatment_Research	AIDS in Hemophiliac Population|AIDS, Hemophiliac	AIDS related research with a minimum of 20% (or $100,000) relevance to individuals with hemophilia, a sex-linked hereditary blood defect that occurs almost exclusively in males and is characterized by delayed clotting of the blood and consequent difficulty in controlling hemorrhage even after minor injuries. (FMB)
C4988	AIDS_Associated_Opportunistic_Infections	Opportunistic_Infections	AIDS Associated Opportunistic Infection|AIDS, Opportunistic Infection	AIDS related research with a minimum of 20% (or $100,000) research efforts related to the biology, pathogenesis, development of vaccines, epidemiology, pathophysiology, diagnosis and treatment of opportunistic infections associated with HIV infection. To include: Pneumocystosis, toxoplasmosis, cryptosporidiosis, candidiasis, cryptococcosis, mycobacteriosis, cytomegalovirus, papillomavirus, herpes simplex, JC virus, coccidioides, hairy leukoplakia, and HIV-related periodontal disease. (FMB)
C4989	Childhood_Leukemia	Childhood_Hematopoietic_Neoplasm|Leukemia	Childhood Leukemia
C4991	Diseases_Associated_with_AIDS	Immunodeficiency-Related_Disorder	AIDS-Related Disorder|Disease Associated with AIDS|Diseases Associated with AIDS
C4992	Environment-Related_Malignant_Neoplasm	Environment-Related_Neoplasm	Environment-Related Malignant Neoplasm|Environment-Related Cancer|Environmental Cancer|Environmental Cancers|Environmental Malignant Neoplasm	Cancers caused by exposure to carcinogens in the general environment
C4993	Occupational_Malignant_Neoplasm	Occupational_Neoplasm	Occupational Malignant Neoplasm|Occupational Cancer	Malignant neoplasm secondary to occupational exposure to carcinogens.
C4994	Stage_II_Bladder_Squamous_Cell_Carcinoma	Bladder_Squamous_Cell_Carcinoma|Stage_II_Bladder_Cancer	Stage II Bladder Squamous Cell Carcinoma	TNM staging: T2a/b N0 M0-T2a means tumor invades superficial muscle, T2b means tumor invades deep muscle, N0 means no regional lymph node mets, M0 means no distant mets.
C4995	Recurrent_Bladder_Adenocarcinoma	Bladder_Adenocarcinoma|Recurrent_Bladder_Cancer	Recurrent Bladder Adenocarcinoma|Bladder Adenocarcinoma, Recurrent|Recurrent Adenocarcinoma of Bladder|Recurrent Adenocarcinoma of Urinary Bladder|Recurrent Adenocarcinoma of the Bladder|Recurrent Adenocarcinoma of the Urinary Bladder|Recurrent Urinary Bladder Adenocarcinoma|Relapsed Adenocarcinoma of Bladder|Relapsed Adenocarcinoma of Urinary Bladder|Relapsed Adenocarcinoma of the Bladder|Relapsed Adenocarcinoma of the Urinary Bladder|Relapsed Bladder Adenocarcinoma|Relapsed Urinary Bladder Adenocarcinoma	A recurrence of adenocarcinoma of the bladder after a period of remission.
C4996	Stage_I_Extragonadal_Primary_Seminoma	Extragonadal_Primary_Seminoma|Stage_I_Seminoma	Stage I Extragonadal Primary Seminoma
C4997	Refractory_Nodal_Marginal_Zone_B-Cell_Lymphoma	Nodal_Marginal_Zone_B-Cell_Lymphoma|Refractory_Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Refractory Nodal Marginal Zone B-Cell Lymphoma|Nodal Marginal Zone B-Cell Lymphoma Refractory	Nodal marginal zone B-cell lymphoma resistant to treatment
C4998	Recurrent_Nodal_Marginal_Zone_B-Cell_Lymphoma	Nodal_Marginal_Zone_B-Cell_Lymphoma|Recurrent_B-Cell_Non-Hodgkin_s_Lymphoma	Recurrent Nodal Marginal Zone B-Cell Lymphoma|Relapsed Nodal Marginal Zone B-Cell Lymphoma
C4999	Stage_IV_High-Grade_Burkitt-Like_Lymphoma	High-Grade_Burkitt-Like_Lymphoma	Stage IV High Grade Burkitt-Like Lymphoma	Stage IV NHL means disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (from PDQ)
C5000	Stage_III_High-Grade_Burkitt-Like_Lymphoma	High-Grade_Burkitt-Like_Lymphoma	Stage III High Grade Burkitt-Like Lymphoma	Stage III NHL means involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (from PDQ)
C5001	Stage_II_High-Grade_Burkitt-Like_Lymphoma	High-Grade_Burkitt-Like_Lymphoma	Stage II High Grade Burkitt-Like Lymphoma	Stage II NHL means involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (from PDQ)
C5002	Stage_I_High-Grade_Burkitt-Like_Lymphoma	High-Grade_Burkitt-Like_Lymphoma	Stage I High Grade Burkitt-Like Lymphoma	Stage I NHL means involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (from PDQ)
C5003	Refractory_High-Grade_Burkitt-Like_Lymphoma	High-Grade_Burkitt-Like_Lymphoma	Refractory High Grade Burkitt-Like Lymphoma	High grade B-cell lymphoma Burkitt-like lymphoma resistant to treatment.
C5004	Recurrent_High-Grade_Burkitt-Like_Lymphoma	High-Grade_Burkitt-Like_Lymphoma	Recurrent High Grade Burkitt-Like Lymphoma	The reemergence of high grade B-cell lymphoma Burkitt-like lymphoma after a period of remission
C5005	High-Grade_Burkitt-Like_Lymphoma	High-Grade_B-Cell_Non-Hodgkin_s_Lymphoma	High Grade Burkitt-Like Lymphoma
C5006	Stage_IV_Follicular_Lymphoma	Follicular_Lymphoma|Stage_IV_B-Cell_Non-Hodgkin_s_Lymphoma	Stage IV Follicular Lymphoma|Follicle Centre Lymphoma, Follicular Grade I, II, III Stage IV	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C5007	Recurrent_Follicular_Lymphoma	Follicular_Lymphoma|Recurrent_B-Cell_Non-Hodgkin_s_Lymphoma	Recurrent Follicular Lymphoma
C5008	Recurrent_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma|Recurrent_B-Cell_Non-Hodgkin_s_Lymphoma	Recurrent Burkitt's Lymphoma|Relapsed Burkitt's Lymphoma	The reemergence of Burkitt's lymphoma after a period of remission.
C5009	Stage_II_Supradiaphragmatic_Hodgkin_s_Lymphoma	Stage_II_Hodgkin_s_Lymphoma	Stage II Supradiaphragmatic Hodgkin's Lymphoma|Stage II Hodgkin's Disease above the Diaphragm|Stage II Hodgkin's Lymphoma above the Diaphragm|Stage II Supradiaphragmatic Hodgkin Lymphoma|Stage II Supradiaphragmatic Hodgkin's Disease	Stage II adult Hodgkin's disease means the involvement of two or more lymph node regions on the superior side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph node(s) with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript.
C5010	Stage_II_Subdiaphragmatic_Hodgkin_s_Lymphoma	Stage_II_Hodgkin_s_Lymphoma	Stage II Subdiaphragmatic Hodgkin's Lymphoma|Stage II Hodgkin's Disease below the Diaphragm|Stage II Hodgkin's Lymphoma below the Diaphragm|Stage II Subdiaphragmatic Hodgkin Lymphoma|Stage II Subdiaphragmatic Hodgkin's Disease	Stage II adult Hodgkin's disease means the involvement of two or more lymph node regions on the inferior side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph node(s) with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript.
C5011	Stage_I_Supradiaphragmatic_Hodgkin_s_Lymphoma	Stage_I_Hodgkin_s_Lymphoma	Stage I Supradiaphragmatic Hodgkin's Lymphoma|Stage I Hodgkin's Disease above the Diaphragm|Stage I Hodgkin's Lymphoma above the Diaphragm|Stage I Supradiaphragmatic Hodgkin Lymphoma|Stage I Supradiaphragmatic Hodgkin's Disease
C5012	Stage_I_Subdiaphragmatic_Hodgkin_s_Lymphoma	Stage_I_Hodgkin_s_Lymphoma	Stage I Subdiaphragmatic Hodgkin's Lymphoma|Stage I Hodgkin's Disease below the Diaphragm|Stage I Hodgkin's Lymphoma below the Diaphragm|Stage I Subdiaphragmatic Hodgkin Lymphoma|Stage I Subdiaphragmatic Hodgkin's Disease
C5014	Recurrent_Squamous_Cell_Lung_Carcinoma	Squamous_Cell_Lung_Carcinoma	Recurrent Squamous Cell Lung Carcinoma|Recurrent Squamous Cell Carcinoma of Lung|Recurrent Squamous Cell Carcinoma of the Lung	The re-emergence of squamous cell lung carcinoma after a period of remission. (NCI05)
C5015	Stage_II_Rectosigmoid_Cancer	Rectosigmoid_Carcinoma|Stage_II_Colorectal_Cancer	Stage II Rectosigmoid Cancer|Stage II Rectosigmoid Carcinoma	Stage 2 includes T3,T4,N0,M0.  T3: Tumor invades through the muscularis propria into the subserosa, or into nonperitonealized pericolic or perirectal tissues.  T4: Tumor directly invades other organs or structures, and/or perforates the visceral peritoneum (PDQ).
C5016	Stage_I_Rectosigmoid_Cancer	Rectosigmoid_Carcinoma|Stage_I_Colorectal_Cancer	Stage I Rectosigmoid Cancer|Stage I Rectosigmoid Carcinoma	Stage 1 includes T1,T2,N0,M0.  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria (PDQ).
C5017	Stage_0_Rectosigmoid_Cancer	Rectosigmoid_Carcinoma|Stage_0_Colorectal_Cancer	Stage 0 Rectosigmoid Cancer|Stage 0 Rectosigmoid Carcinoma	Stage 0 includes Tis,N0,M0.  Tis: Carcinoma in situ: intraepithelial or invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis (PDQ)
C5018	Unresectable_Pancreatic_Cancer	Pancreatic_Carcinoma	Unresectable Pancreatic Cancer|Non-Resectable Carcinoma of Pancreas|Non-Resectable Carcinoma of the Pancreas|Non-Resectable Pancreas Carcinoma|Non-Resectable Pancreatic Carcinoma|Pancreatic Carcinoma, Non-Resectable|Unresectable Pancreatic Carcinoma
C5019	Stage_IV_Esophageal_Squamous_Cell_Carcinoma	Esophageal_Squamous_Cell_Carcinoma|Stage_IV_Esophageal_Cancer	Stage IV Esophageal Squamous Cell Carcinoma|Esophageal Squamous Cell Carcinoma Stage IV|Metastatic Esophageal Squamous Cell Carcinoma|Metastatic Esophagus Squamous Cell Carcinoma|Metastatic Squamous Cell Carcinoma of Esophagus|Metastatic Squamous Cell Carcinoma of the Esophagus|Stage IV Esophagus Squamous Cell Carcinoma|Stage IV Squamous Cell Carcinoma of Esophagus|Stage IV Squamous Cell Carcinoma of the Esophagus	Stage IV includes: IV: (Any T, Any N, M1); IVA: (Any T, Any N, M1a); IVB: (Any T, Any N, M1b).  M1: Distant metastasis.  Tumors of the lower thoracic esophagus.  M1a: Metastasis in celiac lymph nodes.  M1b: Other distant metastasis.  Tumors of the mid-thoracic esophagus: M1a: Not applicable.  M1b: Nonregional lymph nodes and/or other distant metastasis.  Tumors of the upper thoracic esophagus.  M1a: Metastasis in cervical nodes.  M1b: Other distant metastasis (AJCC 6th ed.) - 2003
C5020	Stage_III_Esophageal_Squamous_Cell_Carcinoma	Esophageal_Squamous_Cell_Carcinoma|Stage_III_Esophageal_Cancer	Stage III Esophageal Squamous Cell Carcinoma|Esophageal Squamous Cell Carcinoma Stage III|Oesophageal Squamous Cell Carcinoma Stage III|Stage III Esophagus Squamous Cell Carcinoma|Stage III Squamous Cell Carcinoma of Esophagus|Stage III Squamous Cell Carcinoma of the Esophagus	Stage III includes: (T3, N1, M0); (T4, Any N, M0). T4: Tumor invades adjacent structures.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003
C5021	Stage_II_Esophageal_Squamous_Cell_Carcinoma	Esophageal_Squamous_Cell_Carcinoma|Stage_II_Esophageal_Cancer	Stage II Esophageal Squamous Cell Carcinoma|Esophageal Squamous Cell Carcinoma Stage II|Oesophageal Squamous Cell Carcinoma Stage II|Stage II Esophagus Squamous Cell Carcinoma|Stage II Squamous Cell Carcinoma of Esophagus|Stage II Squamous Cell Carcinoma of the Esophagus	Stage II includes: IIA: (T2, N0, M0); (T3, N0, M0); IIB: (T1, N1, M0); (T2, N1, M0).  T1: Tumor invades lamina propria or submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades adventitia.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003
C5022	Stage_I_Esophageal_Squamous_Cell_Carcinoma	Esophageal_Squamous_Cell_Carcinoma|Stage_I_Esophageal_Cancer	Stage I Esophageal Squamous Cell Carcinoma|Esophageal Squamous Cell Carcinoma Stage I|Oesophageal Squamous Cell Carcinoma Stage I|Stage I Esophagus Squamous Cell Carcinoma|Stage I Squamous Cell Carcinoma of Esophagus|Stage I Squamous Cell Carcinoma of the Esophagus	Stage I includes: T1, N0, M0.  T1: Tumor invades lamina propria or submucosa.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003
C5023	Stage_0_Esophageal_Squamous_Cell_Carcinoma	Esophageal_High-Grade_Squamous_Intraepithelial_Neoplasia|Esophageal_Squamous_Cell_Carcinoma|Stage_0_Esophageal_Cancer|Stage_0_Squamous_Cell_Carcinoma	Stage 0 Esophageal Squamous Cell Carcinoma|Esophageal Squamous Cell Carcinoma Stage 0|Esophageal Squamous Cell Carcinoma in situ|Esophagus Squamous Cell Carcinoma in situ|Oesophageal Squamous Cell Carcinoma Stage 0|Squamous Cell Carcinoma in situ of Esophagus|Squamous Cell Carcinoma in situ of the Esophagus|Stage 0 Esophagus Squamous Cell Carcinoma|Stage 0 Squamous Cell Carcinoma of Esophagus|Stage 0 Squamous Cell Carcinoma of the Esophagus	Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003
C5024	Prostate_Carcinoid_Tumor	Carcinoid_Tumor|Prostate_Neuroendocrine_Neoplasm	Prostate Carcinoid Tumor|Carcinoid Neoplasm of Prostate|Carcinoid Neoplasm of the Prostate|Carcinoid Tumor of Prostate|Carcinoid Tumor of the Prostate|Prostate Carcinoid Neoplasm	A usually slow-growing neuroendocrine tumor affecting the prostate gland. --2003
C5026	Recurrent_Nasal_Type_NK_T-Cell_Lymphoma	Nasal_Type_Extranodal_NK_T-Cell_Lymphoma|Recurrent_Mature_T-and_NK-Cell_Non-Hodgkin_s_Lymphoma	Recurrent Nasal Type NK/T-Cell Lymphoma|Recurrent Angiocentric Lymphoma|Relapsed Angiocentric Lymphoma|Relapsed Nasal Type NK/T-Cell Lymphoma	The reemergence of angiocentric lymphoma after a period of remission.
C5027	Malignant_Testicular_Non-Seminomatous_Germ_Cell_Tumor	Malignant_Testicular_Germ_Cell_Tumor|Testicular_Non-Seminomatous_Germ_Cell_Tumor	Malignant Testicular Non-Seminomatous Germ Cell Tumor|Malignant Non-Seminomatous Germ Cell Cancer of Testis|Malignant Non-Seminomatous Germ Cell Cancer of the Testis|Malignant Non-Seminomatous Germ Cell Neoplasm of Testis|Malignant Non-Seminomatous Germ Cell Neoplasm of the Testis|Malignant Non-Seminomatous Germ Cell Tumor of Testis|Malignant Non-Seminomatous Germ Cell Tumor of the Testis|Malignant Testicular Non-Seminomatous Germ Cell Neoplasm|Testicular Non-Seminomatous Germ Cell Cancer|Testicular Non-Seminomatous Malignant Germ Cell Neoplasm	A classification of testicular cancers that arise in specialized sex cells called germ cells. Nonseminomas include embryonal carcinoma, teratoma, choriocarcinoma, and yolk sac tumor.
C5028	Benign_Verrucous_Lesion	Benign_Epithelial_Skin_Neoplasm	Benign Verrucous Lesion|Wart|wart	A papilloma virus related epithelial overgrowth. It can be located anywhere on the body though when it involves the perineal region it is generally referred to as condyloma acuminata.
C5029	Bile_Duct_Sarcoma	Malignant_Extrahepatic_Bile_Duct_Neoplasm|Soft_Tissue_Sarcoma	Bile Duct Sarcoma|Sarcoma of Bile Duct|Sarcoma of the Bile Duct
C5033	Endocrine_System_Signs_and_Symptoms	Endocrine_System_Finding|Symptom	Endocrine System Signs and Symptoms	Patient complaints, physical findings, laboratory findings referable to the endocrinologic system.
C5034	Disturbance_in_Bowel_Function	Gastrointestinal_System_Signs_and_Symptoms	Disturbance in Bowel Function	Abnormal functioning of the small and/or large intestine.
C5035	Genitourinary_Signs_and_Symptoms	Symptom	Genitourinary Signs and Symptoms|Genital or Reproductive Signs and Symptoms	Patient complaints (symptoms), physical or laboratory findings (signs) related to the genitourinary system.
C5036	Integumentary_System_Signs_and_Symptoms	Integumentary_System_Finding|Symptom	Integumentary System Signs and Symptoms	Patient complaints (symptoms), physical and/or laboratory findings related to the skin or integument.
C5037	Alterations_in_Hearing	Sensory_Manifestations	Alterations in Hearing
C5038	Alterations_in_Smell_or_Taste	Sensory_Manifestations	Alterations in Smell or Taste
C5039	Motor_Manifestations	Neurological_Signs_and_Symptoms	Motor Manifestations
C5040	Sensory_Manifestations	Neurological_Signs_and_Symptoms	Sensory Manifestations
C5041	Speech_Manifestations	Neurological_Signs_and_Symptoms	Speech Manifestations|Speech Disorder
C5042	Visual_Manifestations	Sensory_Manifestations	Visual Manifestations
C5043	Ventilation_or_Perfusion_Signs_and_Symptoms	Symptom	Ventilation or Perfusion Signs and Symptoms
C5044	Fluid_and_Electrolyte_Manifestation	Cardiovascular_System_Finding	Fluid and Electrolyte Manifestation
C5047	AIDS-Related_Malignant_Anal_Neoplasm	AIDS-Related_Malignant_Neoplasm|Malignant_Anal_Neoplasm	AIDS-Related Malignant Anal Neoplasm|AIDS-Related Malignant Anal Tumor|AIDS-Related Malignant Neoplasm of Anus|AIDS-Related Malignant Neoplasm of the Anus|AIDS-Related Malignant Tumor of Anus|AIDS-Related Malignant Tumor of the Anus	Anal cancer secondary to AIDS
C5051	AIDS-Related_Non-Hodgkin_s_Lymphoma	AIDS-Related_Lymphoma|Non-Hodgkin_s_Lymphoma	AIDS-Related Non-Hodgkin's Lymphoma
C5052	AIDS-Related_Malignant_Cervical_Neoplasm	AIDS-Related_Malignant_Neoplasm|Malignant_Cervical_Neoplasm	AIDS-Related Malignant Cervical Neoplasm|AIDS-Related Malignant Cervical Tumor|AIDS-Related Malignant Cervix Neoplasm|AIDS-Related Malignant Cervix Tumor|AIDS-Related Malignant Cervix Uteri Neoplasm|AIDS-Related Malignant Cervix Uteri Tumor|AIDS-Related Malignant Neoplasm of Cervix|AIDS-Related Malignant Neoplasm of Cervix Uteri|AIDS-Related Malignant Neoplasm of Uterine Cervix|AIDS-Related Malignant Neoplasm of the Cervix|AIDS-Related Malignant Neoplasm of the Cervix Uteri|AIDS-Related Malignant Neoplasm of the Uterine Cervix|AIDS-Related Malignant Tumor of Cervix|AIDS-Related Malignant Tumor of Cervix Uteri|AIDS-Related Malignant Tumor of Uterine Cervix|AIDS-Related Malignant Tumor of the Cervix|AIDS-Related Malignant Tumor of the Cervix Uteri|AIDS-Related Malignant Tumor of the Uterine Cervix|AIDS-Related Malignant Uterine Cervix Neoplasm|AIDS-Related Malignant Uterine Cervix Tumor	Abnormal growth of the cells of the cervix with malignant characteristics. This concept specifically refers to this type of cancer in patients with acquired immunodeficiency syndrome.
C5053	Childhood_Testicular_Neoplasm	Childhood_Neoplasm|Testicular_Neoplasm	Childhood Testicular Neoplasm|Childhood Neoplasm of Testis|Childhood Neoplasm of the Testis|Pediatric Neoplasm of Testis|Pediatric Neoplasm of the Testis|Pediatric Testicular Neoplasm|Testicular Tumor, Childhood
C5054	Primary_Cerebral_Lymphoma_in_Immunocompetent_Host	Cerebral_Lymphoma	Primary Cerebral Lymphoma in Immunocompetent Host
C5055	Cerebral_Hodgkin_s_Lymphoma	Cerebral_Lymphoma|Hodgkin_s_Lymphoma	Cerebral Hodgkin's Lymphoma|Cerebral Hodgkin Lymphoma|Cerebral Hodgkin's Disease|Primary Cerebral Hodgkin Lymphoma|Primary Cerebral Hodgkin's Disease|Primary Cerebral Hodgkin's Lymphoma|Primary Hodgkin's Disease of Cerebrum|Primary Hodgkin's Disease of the Cerebrum|Primary Hodgkin's Lymphoma of Cerebrum|Primary Hodgkin's Lymphoma of the Cerebrum
C5056	Primary_Cerebral_Hodgkin_s_Lymphoma	Retired_Concepts	Primary Cerebral Hodgkin's Lymphoma|Primary Cerebral Hodgkin Lymphoma|Primary Cerebral Hodgkin's Disease|Primary Hodgkin's Disease of Cerebrum|Primary Hodgkin's Disease of the Cerebrum|Primary Hodgkin's Lymphoma of Cerebrum|Primary Hodgkin's Lymphoma of the Cerebrum
C5057	Secondary_Cerebral_Hodgkin_s_Lymphoma	Hodgkin_s_Lymphoma	Metastatic Hodgkin's Lymphoma to Cerebral Hemisphere|Secondary Cerebral Hodgkin Lymphoma|Secondary Cerebral Hodgkin's Disease|Secondary Cerebral Hodgkin's Lymphoma
C5059	Recurrent_Epithelioid_Sarcoma	Epithelioid_Sarcoma	Recurrent Epithelioid Sarcoma|Epithelioid Sarcoma, Recurrent|Recurrent Epithelioid Cell Sarcoma|Relapsed Epithelioid Cell Sarcoma|Relapsed Epithelioid Sarcoma
C5060	Primary_Fibrosarcoma	Fibrosarcoma	Primary Fibrosarcoma|Non-Metastatic Fibrosarcoma
C5061	Urethral_Papilloma	Benign_Urethral_Neoplasm|Urothelial_Papilloma	Urethral Urothelial Papilloma	Papilloma's are benign epithelial neoplasms that produce visible warty projections from epithelial surfaces.  Papilloma's of the urethra typically occur just within or on the external meatus. - 2003
C5062	Cancer_Fatigue	Complication|Fatigue	Cancer Fatigue	A debilitating tiredness or total lack of energy, often reported as the most common symptom in individuals with cancer.  Cancer fatigue can result from chemotherapy, radiation therapy, surgery, and other treatments; chemotherapy-induced anemia is a very frequent cause. -- 2004
C5063	Endobronchial_Lipoma	Benign_Lung_Neoplasm|Lipoma|Lung_Soft_Tissue_Neoplasm	Endobronchial Lipoma	A fatty tumor within the bronchi
C5064	Stage_I_Lymphocyte_Depleted_Hodgkin_s_Lymphoma	Lymphocyte_Depleted_Hodgkin_s_Lymphoma|Stage_I_Hodgkin_s_Lymphoma	Stage I Lymphocyte Depleted Hodgkin's Lymphoma|Stage I Hodgkin's Disease Lymphocyte Depletion Type|Stage I Hodgkin's Lymphoma Lymphocyte Depleted|Stage I Hodgkin's Lymphoma Lymphocyte Depletion Type	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C5065	Stage_I_Subdiaphragmatic_Lymphocyte_Depleted_Hodgkin_s_Lymphoma	Stage_I_Lymphocyte_Depleted_Hodgkin_s_Lymphoma|Stage_I_Subdiaphragmatic_Hodgkin_s_Lymphoma	Stage I Subdiaphragmatic Lymphocyte Depleted Hodgkin's Lymphoma|Stage I Hodgkin's Disease Lymphocyte Depletion Type below the Diaphragm|Stage I Hodgkin's Lymphoma Lymphocyte Depletion Type below the Diaphragm|Stage I Subdiaphragmatic Hodgkin Lymphoma Lymphocyte Depleted|Stage I Subdiaphragmatic Hodgkin's Disease Lymphocyte Depletion Type|Subdiaphragm Stage I Hodgkin's Lymphoma Lymphocyte Depletion Type
C5066	Stage_I_Supradiaphragmatic_Lymphocyte_Depleted_Hodgkin_s_Lymphoma	Stage_I_Lymphocyte_Depleted_Hodgkin_s_Lymphoma|Stage_I_Supradiaphragmatic_Hodgkin_s_Lymphoma	Stage I Supradiaphragmatic Lymphocyte Depleted Hodgkin's Lymphoma|Stage I Hodgkin's Disease Lymphocyte Depletion Type above the Diaphragm|Stage I Hodgkin's Lymphoma Lymphocyte Depleted above the Diaphragm|Stage I Supradiaphragmatic Hodgkin Lymphoma Lymphocyte Depleted|Stage I Supradiaphragmatic Hodgkin's Disease Lymphocyte Depletion Type|Stage I Supradiaphragmatic Hodgkin's Lymphoma Lymphocyte Depleted
C5067	Stage_II_Lymphocyte_Depleted_Hodgkin_s_Lymphoma	Lymphocyte_Depleted_Hodgkin_s_Lymphoma|Stage_II_Hodgkin_s_Lymphoma	Stage II Lymphocyte Depleted Hodgkin's Lymphoma|Stage II Hodgkin's Disease Lymphocyte Depletion Type|Stage II Hodgkin's Lymphoma Lymphocyte Depleted|Stage II Hodgkin's Lymphoma Lymphocyte Depletion Type	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C5068	Stage_II_Subdiaphragmatic_Lymphocyte_Depleted_Hodgkin_s_Lymphoma	Stage_II_Lymphocyte_Depleted_Hodgkin_s_Lymphoma|Stage_II_Subdiaphragmatic_Hodgkin_s_Lymphoma	Stage II Subdiaphragmatic Lymphocyte Depleted Hodgkin's Lymphoma|Stage II Hodgkin's Disease Lymphocyte Depletion Type below the Diaphragm|Stage II Hodgkin's Lymphoma Lymphocyte Depletion Type below the Diaphragm|Stage II Subdiaphragmatic Hodgkin Lymphoma Lymphocyte Depleted|Stage II Subdiaphragmatic Hodgkin's Disease Lymphocyte Depletion Type|Stage II Subdiaphragmatic Hodgkin's Lymphoma Lymphocyte Depleted|Subdiaphragm Stage II Hodgkin's Lymphoma Lymphocyte Depletion Type
C5069	Stage_II_Supradiaphragmatic_Lymphocyte_Depleted_Hodgkin_s_Lymphoma	Stage_II_Lymphocyte_Depleted_Hodgkin_s_Lymphoma|Stage_II_Supradiaphragmatic_Hodgkin_s_Lymphoma	Stage II Supradiaphragmatic Lymphocyte Depleted Hodgkin's Lymphoma|Stage II Hodgkin's Disease Lymphocyte Depletion Type above the Diaphragm|Stage II Hodgkin's Lymphoma Lymphocyte Depletion Type above the Diaphragm|Stage II Supradiaphragmatic Hodgkin Lymphoma Lymphocyte Depleted|Stage II Supradiaphragmatic Hodgkin's Disease Lymphocyte Depletion Type|Stage II Supradiaphragmatic Hodgkin's Lymphoma Lymphocyte Depleted
C5070	Stage_II_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma	Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma|Stage_II_Hodgkin_s_Lymphoma	Stage II Nodular Lymphocyte Predominant Hodgkin's Lymphoma|Stage II Hodgkin's Disease Nodular Lymphocyte Predominance Type|Stage II Hodgkin's Lymphoma Nodular Lymphocyte Predominance Type|Stage II Nodular Lymphocyte Predominant Hodgkin's Disease	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C5071	Stage_II_Subdiaphragmatic_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma	Stage_II_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma|Stage_II_Subdiaphragmatic_Hodgkin_s_Lymphoma	Stage II Subdiaphragmatic Nodular Lymphocyte Predominant Hodgkin's Lymphoma|Stage II Hodgkin's Disease Nodular Lymphocyte Predominance Type below the Diaphragm|Stage II Hodgkin's Lymphoma Nodular Lymphocyte Predominance Type Below the Diaphragm|Stage II Subdiaphragmatic Hodgkin Lymphoma Nodular Lymphocyte Predominant Type|Stage II Subdiaphragmatic Hodgkin's Disease Nodular Lymphocyte Predominance Type|Stage II Subdiaphragmatic Hodgkin's Lymphoma Nodular Lymphocyte Predominant Type|Stage II Subdiaphragmatic Nodular Lymphocyte Predominant Hodgkin Lymphoma|Subdiaphragm Stage II Hodgkin's Lymphoma Nodular Lymphocyte Predominance Type
C5072	Stage_II_Supradiaphragmatic_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma	Stage_II_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma|Stage_II_Supradiaphragmatic_Hodgkin_s_Lymphoma	Stage II Supradiaphragmatic Nodular Lymphocyte Predominant Hodgkin's Lymphoma|Stage II Hodgkin's Disease Nodular Lymphocyte Predominance Type above the Diaphragm|Stage II Hodgkin's Lymphoma Nodular Lymphocyte Predominance Type above the Diaphragm|Stage II Supradiaphragmatic Hodgkin Lymphoma Nodular Lymphocyte Predominant Type|Stage II Supradiaphragmatic Hodgkin's Disease Nodular Lymphocyte Predominance Type|Stage II Supradiaphragmatic Hodgkin's Lymphoma Nodular Lymphocyte Predominant Type|Stage II Supradiaphragmatic Nodular Lymphocyte Predominant Hodgkin Lymphoma
C5073	Stage_I_Subdiaphragmatic_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma	Stage_I_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma|Stage_I_Subdiaphragmatic_Hodgkin_s_Lymphoma	Stage I Subdiaphragmatic Nodular Lymphocyte Predominant Hodgkin's Lymphoma|Stage I Hodgkin's Disease Nodular Lymphocyte Predominance Type below the Diaphragm|Stage I Hodgkin's Lymphoma Nodular Lymphocyte Predominance Type below the Diaphragm|Stage I Subdiaphragmatic Hodgkin's Disease Nodular Lymphocyte Predominance Type|Stage I Subdiaphragmatic Hodgkin's Lymphoma Nodular Lymphocyte Predominant Type|Stage I Subdiaphragmatic Nodular Lymphocyte Predominant Hodgkin Lymphoma|Subdiaphragm Stage I Hodgkin's Lymphoma Nodular Lymphocyte Predominance Type
C5074	Stage_I_Supradiaphragmatic_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma	Stage_I_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma|Stage_I_Supradiaphragmatic_Hodgkin_s_Lymphoma	Stage I Supradiaphragmatic Nodular Lymphocyte Predominant Hodgkin's Lymphoma|Stage I Hodgkin's Disease Nodular Lymphocyte Predominance Type above the Diaphragm|Stage I Hodgkin's Lymphoma Nodular Lymphocyte Predominance Type above the Diaphragm|Stage I Supradiaphragmatic Hodgkin Lymphoma Nodular Lymphocyte Predominant Type|Stage I Supradiaphragmatic Hodgkin's Disease Nodular Lymphocyte Predominance Type|Stage I Supradiaphragmatic Hodgkin's Lymphoma Nodular Lymphocyte Predominant Type|Stage I Supradiaphragmatic Nodular Lymphocyte Predominant Hodgkin Lymphoma|Supradiaphragm Stage I Hodgkin's Lymphoma Nodular Lymphocyte Predominance Type
C5075	Stage_I_Subdiaphragmatic_Mixed_Cellularity_Hodgkin_s_Lymphoma	Stage_I_Mixed_Cellularity_Hodgkin_s_Lymphoma|Stage_I_Subdiaphragmatic_Hodgkin_s_Lymphoma	Stage I Subdiaphragmatic Mixed Cellularity Hodgkin's Lymphoma|Stage I Mixed Cellularity Hodgkin's Disease below the Diaphragm|Stage I Mixed Cellularity Hodgkin's Lymphoma below the Diaphragm|Stage I Subdiaphragmatic Mixed Cellularity Hodgkin Lymphoma|Stage I Subdiaphragmatic Mixed Cellularity Hodgkin's Disease
C5076	Stage_I_Supradiaphragmatic_Mixed_Cellularity_Hodgkin_s_Lymphoma	Stage_I_Mixed_Cellularity_Hodgkin_s_Lymphoma|Stage_I_Supradiaphragmatic_Hodgkin_s_Lymphoma	Stage I Supradiaphragmatic Mixed Cellularity Hodgkin's Lymphoma|Stage I Mixed Cellularity Hodgkin's Disease above the Diaphragm|Stage I Mixed Cellularity Hodgkin's Lymphoma above the Diaphragm|Stage I Supradiaphragmatic Mixed Cellularity Hodgkin Lymphoma|Stage I Supradiaphragmatic Mixed Cellularity Hodgkin's Disease
C5077	Stage_II_Mixed_Cellularity_Hodgkin_s_Lymphoma	Mixed_Cellularity_Hodgkin_s_Lymphoma|Stage_II_Hodgkin_s_Lymphoma	Stage II Mixed Cellularity Hodgkin's Lymphoma|Mixed Cellularity Hodgkin's Disease Stage II|Mixed Cellularity Hodgkin's Lymphoma Stage II|Stage II Mixed Cellularity Hodgkin Lymphoma|Stage II Mixed Cellularity Hodgkin's Disease	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C5078	Stage_II_Subdiaphragmatic_Mixed_Cellularity_Hodgkin_s_Lymphoma	Stage_II_Mixed_Cellularity_Hodgkin_s_Lymphoma|Stage_II_Subdiaphragmatic_Hodgkin_s_Lymphoma	Stage II Subdiaphragmatic Mixed Cellularity Hodgkin's Lymphoma|Stage II Mixed Cellularity Hodgkin's Disease below the Diaphragm|Stage II Mixed Cellularity Hodgkin's Lymphoma below the Diaphragm|Stage II Subdiaphragmatic Mixed Cellularity Hodgkin Lymphoma|Stage II Subdiaphragmatic Mixed Cellularity Hodgkin's Disease
C5079	Stage_I_Subdiaphragmatic_Nodular_Sclerosis_Hodgkin_s_Lymphoma	Stage_I_Nodular_Sclerosis_Hodgkin_s_Lymphoma|Stage_I_Subdiaphragmatic_Hodgkin_s_Lymphoma	Stage I Subdiaphragmatic Nodular Sclerosis Hodgkin's Lymphoma|Stage I Nodular Sclerosis Hodgkin's Disease below the Diaphragm|Stage I Nodular Sclerosis Hodgkin's Lymphoma below the Diaphragm|Stage I Subdiaphragmatic Nodular Sclerosis Hodgkin Lymphoma|Stage I Subdiaphragmatic Nodular Sclerosis Hodgkin's Disease
C5080	Stage_I_Supradiaphragmatic_Nodular_Sclerosis_Hodgkin_s_Lymphoma	Stage_I_Nodular_Sclerosis_Hodgkin_s_Lymphoma|Stage_I_Supradiaphragmatic_Hodgkin_s_Lymphoma	Stage I Supradiaphragmatic Nodular Sclerosis Hodgkin's Lymphoma|Stage I Nodular Sclerosis Hodgkin's Disease above the Diaphragm|Stage I Nodular Sclerosis Hodgkin's Lymphoma above the Diaphragm|Stage I Supradiaphragmatic Nodular Sclerosis Hodgkin Lymphoma|Stage I Supradiaphragmatic Nodular Sclerosis Hodgkin's Disease
C5081	Stage_II_Nodular_Sclerosis_Hodgkin_s_Lymphoma	Nodular_Sclerosis_Hodgkin_s_Lymphoma|Stage_II_Hodgkin_s_Lymphoma	Stage II Nodular Sclerosis Hodgkin's Lymphoma|Nodular Sclerosis Hodgkin's Disease Stage II|Nodular Sclerosis Hodgkin's Lymphoma Stage II|Stage II Nodular Sclerosis Hodgkin Lymphoma|Stage II Nodular Sclerosis Hodgkin's Disease	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C5082	Stage_II_Subdiaphragmatic_Nodular_Sclerosis_Hodgkin_s_Lymphoma	Stage_II_Nodular_Sclerosis_Hodgkin_s_Lymphoma|Stage_II_Subdiaphragmatic_Hodgkin_s_Lymphoma	Stage II Subdiaphragmatic Nodular Sclerosis Hodgkin's Lymphoma|Stage II Nodular Sclerosis Hodgkin's Disease below the Diaphragm|Stage II Nodular Sclerosis Hodgkin's Lymphoma below the Diaphragm|Stage II Subdiaphragmatic Nodular Sclerosis Hodgkin Lymphoma|Stage II Subdiaphragmatic Nodular Sclerosis Hodgkin's Disease
C5083	Stage_II_Supradiaphragmatic_Nodular_Sclerosis_Hodgkin_s_Lymphoma	Stage_II_Nodular_Sclerosis_Hodgkin_s_Lymphoma|Stage_II_Supradiaphragmatic_Hodgkin_s_Lymphoma	Stage II Supradiaphragmatic Nodular Sclerosis Hodgkin's Lymphoma|Stage II Nodular Sclerosis Hodgkin's Disease above the Diaphragm|Stage II Nodular Sclerosis Hodgkin's Lymphoma above the Diaphragm|Stage II Supradiaphragmatic Nodular Sclerosis Hodgkin Lymphoma|Stage II Supradiaphragmatic Nodular Sclerosis Hodgkin's Disease
C5084	Stage_IV_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma|Stage_IV_B-Cell_Non-Hodgkin_s_Lymphoma	Stage IV Burkitt's Lymphoma|Burkitt's Lymphoma Stage IV	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C5085	Stage_I_Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue|Stage_I_B-Cell_Non-Hodgkin_s_Lymphoma	Stage I Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue|Extranodal Marginal Zone B-Cell Lymphoma (MALT Type) Stage I|MALT Type Extranodal Marginal Zone B-Cell Lymphoma Stage I|Stage I Extranodal Marginal Zone B-Cell Lymphoma (MALT Type )
C5086	Stage_II_Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue|Stage_II_B-Cell_Non-Hodgkin_s_Lymphoma	Stage II Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue|Extranodal Marginal Zone B-Cell Lymphoma (MALT Type) Stage II|MALT Type Extranodal Marginal Zone B-Cell Lymphoma Stage II|Stage II Extranodal Marginal Zone B-Cell Lymphoma (MALT Type )
C5087	Stage_III_Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue|Stage_III_B-Cell_Non-Hodgkin_s_Lymphoma	Stage III Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue|Extranodal Marginal Zone B-Cell Lymphoma (MALT Type) Stage III|MALT Type Extranodal Marginal Zone B-Cell Lymphoma Stage III|Stage III Extranodal Marginal Zone B-Cell Lymphoma (MALT Type )
C5088	Stage_IV_Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue|Stage_IV_B-Cell_Non-Hodgkin_s_Lymphoma	Stage IV Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue|Extranodal Marginal Zone B-Cell Lymphoma (MALT Type) Stage IV|MALT Type Extranodal Marginal Zone B-Cell Lymphoma Stage IV|Stage IV Extranodal Marginal Zone B-Cell Lymphoma (MALT Type)
C5089	Recurrent_Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue|Recurrent_B-Cell_Non-Hodgkin_s_Lymphoma	Recurrent Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue|Recurrent Extranodal Marginal Zone B-Cell Lymphoma (MALT Type)|Relapsed Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue|Relapsed MALT Type Extranodal Marginal Zone B-Cell Lymphoma
C5090	Refractory_Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue|Refractory_Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Refractory Extranodal Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue|Extranodal Marginal Zone B-Cell Lymphoma (MALT Type) Refractory|Refractory Extranodal Marginal Zone B-Cell Lymphoma (MALT Type)
C5091	Stage_I_Splenic_Marginal_Zone_B-Cell_Lymphoma	Splenic_Marginal_Zone_Lymphoma|Stage_I_B-Cell_Non-Hodgkin_s_Lymphoma	Stage I Splenic Marginal Zone B-Cell Lymphoma|Splenic Marginal Zone Lymphoma Stage I|Stage I Splenic Marginal Zone Lymphoma
C5092	Stage_II_Splenic_Marginal_Zone_B-Cell_Lymphoma	Splenic_Marginal_Zone_Lymphoma|Stage_II_B-Cell_Non-Hodgkin_s_Lymphoma	Stage II Splenic Marginal Zone B-Cell Lymphoma|Splenic Marginal Zone Lymphoma Stage II|Stage II Splenic Marginal Zone Lymphoma
C5093	Stage_III_Splenic_Marginal_Zone_B-Cell_Lymphoma	Splenic_Marginal_Zone_Lymphoma|Stage_III_B-Cell_Non-Hodgkin_s_Lymphoma	Stage III Splenic Marginal Zone B-Cell Lymphoma|Splenic Marginal Zone Lymphoma Stage III|Stage III Splenic Marginal Zone Lymphoma
C5094	Stage_IV_Splenic_Marginal_Zone_B-Cell_Lymphoma	Splenic_Marginal_Zone_Lymphoma|Stage_IV_B-Cell_Non-Hodgkin_s_Lymphoma	Stage IV Splenic Marginal Zone B-Cell Lymphoma|Splenic Marginal Zone Lymphoma Stage IV|Stage IV Splenic Marginal Zone Lymphoma
C5095	Recurrent_Splenic_Marginal_Zone_B-Cell_Lymphoma	Recurrent_B-Cell_Non-Hodgkin_s_Lymphoma|Splenic_Marginal_Zone_Lymphoma	Recurrent Splenic Marginal Zone B-Cell Lymphoma|Recurrent Splenic Marginal Zone Lymphoma|Relapsed Splenic Marginal Zone Lymphoma
C5096	Refractory_Splenic_Marginal_Zone_B-Cell_Lymphoma	Refractory_Mature_B-Cell_Non-Hodgkin_s_Lymphoma|Splenic_Marginal_Zone_Lymphoma	Refractory Splenic Marginal Zone B-Cell Lymphoma|Refractory Splenic Marginal Zone Lymphoma
C5097	Brain_Stem_Glioblastoma	Infratentorial_Glioblastoma|Malignant_Brain_Stem_Neoplasm	Brain Stem Glioblastoma|Brain Stem Glioblastoma Multiforme|Brainstem Glioblastoma|Brainstem Glioblastoma Multiforme|Glioblastoma Multiforme of Brain Stem|Glioblastoma Multiforme of Brainstem|Glioblastoma Multiforme of the Brain Stem|Glioblastoma Multiforme of the Brainstem|Grade IV Astrocytic Neoplasm of Brain Stem|Grade IV Astrocytic Neoplasm of Brainstem|Grade IV Astrocytic Neoplasm of the Brain Stem|Grade IV Astrocytic Neoplasm of the Brainstem|Grade IV Astrocytic Tumor of Brain Stem|Grade IV Astrocytic Tumor of Brainstem|Grade IV Astrocytic Tumor of the Brain Stem|Grade IV Astrocytic Tumor of the Brainstem|Grade IV Astrocytoma of Brain Stem|Grade IV Astrocytoma of Brainstem|Grade IV Astrocytoma of the Brain Stem|Grade IV Astrocytoma of the Brainstem|Grade IV Brain Stem Astrocytic Neoplasm|Grade IV Brain Stem Astrocytic Tumor|Grade IV Brain Stem Astrocytoma|Grade IV Brainstem Astrocytic Neoplasm|Grade IV Brainstem Astrocytic Tumor|Grade IV Brainstem Astrocytoma	A malignant, clinically aggressive astrocytic tumor (glioma) localized in the brain stem. -- 2003
C5098	Brain_Stem_Ependymoma	Brain_Stem_Glioma|Ependymoma	Brain Stem Ependymoma|Brainstem Ependymoma|Ependymoma of Brain Stem|Ependymoma of Brainstem|Ependymoma of the Brain Stem|Ependymoma of the Brainstem	Abnormal growth of the infratentorial ependymal cells. This is the rarest form of brainstem tumor. The brainstem glioma/glioblastoma is more common.
C5099	Resectable_Pancreatic_Cancer	Pancreatic_Carcinoma	Resectable Pancreatic Cancer|Pancreatic Carcinoma, Resectable|Resectable Carcinoma of Pancreas|Resectable Carcinoma of the Pancreas|Resectable Pancreas Carcinoma|Resectable Pancreatic Carcinoma
C5100	Renal_Fibroma	Benign_Renal_Neoplasm|Fibroma	Renal Fibroma|Fibroma of Kidney|Fibroma of the Kidney|Kidney Fibroma	A rare benign tumor which can resemble uterine fibroids (leiomyomata) found in the periphery of the kidney. They are rarely symptomatic. Biopsy may be needed to distinguish them from more malignant neoplasms. (ed. Walsh PC Retik AB, Vaughan ED, Wein AJ Campbell's Urology Volume 3, p.2291 7th edition Saunders)
C5101	Renal_Lipoma	Benign_Renal_Neoplasm|Lipoma	Renal Lipoma|Kidney Lipoma|Lipoma of Kidney|Lipoma of the Kidney	A rare benign tumor which may originate from renal parenchymal fat or fat cells within the renal capsule itself. There is a female predominance. Hematuria and pain have been reported as presenting symptoms.  (ed. Walsh PC Retik AB, Vaughan ED, Wein AJ Campbell's Urology Volume 3, p.2291 7th edition Saunders)
C5102	Lacrimal_System_Neoplasm	Eye_Neoplasm	Lacrimal System Neoplasm|Lacrimal System Neoplasms|Lacrimal System Tumor|Neoplasm of Lacrimal System|Neoplasm of the Lacrimal System|Tumor of Lacrimal System|Tumor of the Lacrimal System
C5103	Recurrent_Pharyngeal_Cancer	Pharyngeal_Carcinoma|Recurrent_Head_and_Neck_Cancer	Recurrent Pharyngeal Cancer|Pharyngeal Cancer, Recurrent|Recurrent Cancer of Pharynx|Recurrent Cancer of the Pharynx|Recurrent Carcinoma of Pharynx|Recurrent Carcinoma of the Pharynx|Recurrent Pharyngeal Carcinoma|Recurrent Pharynx Cancer|Recurrent Pharynx Carcinoma|Relapsed Cancer of Pharynx|Relapsed Cancer of the Pharynx|Relapsed Carcinoma of Pharynx|Relapsed Carcinoma of the Pharynx|Relapsed Pharyngeal Cancer|Relapsed Pharyngeal Carcinoma|Relapsed Pharynx Cancer|Relapsed Pharynx Carcinoma
C5104	Stage_II_Supradiaphragmatic_Mixed_Cellularity_Hodgkin_s_Lymphoma	Stage_II_Mixed_Cellularity_Hodgkin_s_Lymphoma|Stage_II_Supradiaphragmatic_Hodgkin_s_Lymphoma	Stage II Supradiaphragmatic Mixed Cellularity Hodgkin's Lymphoma|Stage II Mixed Cellularity Hodgkin's Disease above the Diaphragm|Stage II Mixed Cellularity Hodgkin's Lymphoma above the Diaphragm|Stage II Supradiaphragmatic Mixed Cellularity Hodgkin Lymphoma|Stage II Supradiaphragmatic Mixed Cellularity Hodgkin's Disease
C5105	Colorectal_Adenocarcinoma	Adenocarcinoma|Colorectal_Carcinoma	Colorectal Adenocarcinoma|Adenocarcinoma of Large Bowel|Adenocarcinoma of Large Intestine|Adenocarcinoma of the Large Bowel|Adenocarcinoma of the Large Intestine|Large Bowel Adenocarcinoma|Large Intestine Adenocarcinoma
C5106	Intestinal_Graft_Versus_Host_Disease	Graft_Versus_Host_Disease	Intestinal Graft Versus Host Disease|Intestinal GVHD
C5110	BMT_Nephropathy	Nephropathy|Transplant-Related_Disorder	BMT Nephropathy|Bone Marrow Transplantation Nephropathy	Kidney dysfunction resulting from complications of bone marrow transplantation.
C5111	Benign_Intracranial_Neoplasm	Intracranial_Neoplasm	Benign Intracranial Neoplasm|Benign Intracranial Tumor|Intracranial Neoplasms, Benign
C5112	Autonomic_Nervous_System_Neoplasm	Peripheral_Nervous_System_Neoplasm	Autonomic Nervous System Neoplasm|Autonomic Nervous System Neoplasms|Autonomic Nervous System Tumor|Neoplasm of Autonomic Nervous System|Neoplasm of the Autonomic Nervous System|Tumor of Autonomic Nervous System|Tumor of the Autonomic Nervous System	Benign and malignant neoplasms which arise from or directly involve the central or peripheral elements of the autonomic nervous system.
C5114	Malignant_Intracranial_Neoplasm	Intracranial_Neoplasm	Malignant Intracranial Neoplasm|Intracranial Cancer|Intracranial Neoplasms, Malignant|Intracranial Tumors, Malignant|Malignant Intracranial Tumor
C5115	Malignant_Adult_Brain_Neoplasm	Adult_Brain_Neoplasm	Malignant Adult Brain Neoplasm|Brain Neoplasms, Adult, Malignant|Malignant Adult Brain Tumor|Malignant Tumor of Adult Brain|Malignant Tumor of the Adult Brain
C5116	Benign_Adult_Brain_Neoplasm	Adult_Brain_Neoplasm|Benign_Brain_Neoplasm	Benign Adult Brain Neoplasm|Benign Adult Brain Tumor|Benign Neoplasm of Adult Brain|Benign Neoplasm of the Adult Brain|Benign Tumor of Adult Brain|Benign Tumor of the Adult Brain|Brain Neoplasms, Adult, Benign
C5117	Malignant_Eccrine_Spiradenoma	Eccrine_Spiradenoma|Malignant_Eccrine_Neoplasm	Malignant Eccrine Spiradenoma
C5118	Benign_Schwannoma	Schwannoma	Benign Schwannoma|Benign Neurilemmoma	(shwah-NO-ma)
C5119	Nerve_Root_Neoplasm	Peripheral_Nervous_System_Neoplasm	Nerve Root Neoplasm|Neoplasm of Nerve Root|Neoplasm of the Nerve Root|Neoplasms, Nerve Root|Nerve Root Neoplasms|Nerve Root Tumor|Nerve Root Tumors|Tumor of Nerve Root|Tumor of the Nerve Root	Benign and malignant neoplasms arising from one or more of the cervical, thoracic, lumbar, sacral, or coccygeal nerve roots.  The majority of these tumors are benign.  Clinical manifestations may include pain, weakness and loss of sensation along the course of the involved nerve root.  Large tumors may cause spinal cord compression.  (KEV 8-8-99)
C5120	Vestibulocochlear_Nerve_Neoplasm	Cranial_Nerve_Neoplasm|Vestibulocochlear_Nerve_Disorder	Vestibulocochlear Nerve Neoplasm|Acoustic Nerve Neoplasm|Acoustic Nerve Tumor|Cranial Nerve Eight Neoplasms|Eighth Cranial Nerve Neoplasm|Eighth Cranial Nerve Neoplasms|Eighth Cranial Nerve Tumor|Neoplasm of Acoustic Nerve|Neoplasm of Eighth Cranial Nerve|Neoplasm of Vestibulocochlear Nerve|Neoplasm of the Acoustic Nerve|Neoplasm of the Eighth Cranial Nerve|Neoplasm of the Vestibulocochlear Nerve|Tumor of Acoustic Nerve|Tumor of Eighth Cranial Nerve|Tumor of Vestibulocochlear Nerve|Tumor of the Acoustic Nerve|Tumor of the Eighth Cranial Nerve|Tumor of the Vestibulocochlear Nerve|Vestibuloacoustic Nerve Neoplasms|Vestibulocochlear Nerve Neoplasms|Vestibulocochlear Nerve Tumor	Benign and malignant neoplasms which arise from the eighth cranial nerve, also referred to as the vestibulocochlear nerve. Clinical features may include hearing loss, vertigo, tinnitus, headache and involvement of the trigeminal or facial nerves. (KEV 8-8-99)
C5121	Olfactory_Nerve_Neoplasm	Cranial_Nerve_Neoplasm|Olfactory_Nerve_Disorder	Olfactory Nerve Neoplasm|Cranial Nerve I Neoplasms|First Cranial Nerve Neoplasm|First Cranial Nerve Neoplasms|First Cranial Nerve Tumor|Neoplasm of First Cranial Nerve|Neoplasm of Olfactory Nerve|Neoplasm of the First Cranial Nerve|Neoplasm of the Olfactory Nerve|Neoplasms, Cranial Nerve I|Neoplasms, Olfactory Nerve|Olfactory Nerve Neoplasms|Olfactory Nerve Tumor|Tumor of First Cranial Nerve|Tumor of Olfactory Nerve|Tumor of the First Cranial Nerve|Tumor of the Olfactory Nerve	Benign and malignant neoplasms which arise from or metastasize to the olfactory or first cranial nerve.  Clinical features may include facial pain and impairments of taste or smell.  (KEV 8-8-99)
C5122	Trigeminal_Nerve_Neoplasm	Cranial_Nerve_Neoplasm|Trigeminal_Nerve_Disorder	Trigeminal Nerve Neoplasm|Cranial Nerve V Neoplasms|Cranial Nerve V Tumors|Fifth Cranial Nerve Neoplasm|Fifth Cranial Nerve Tumor|Neoplasm of Fifth Cranial Nerve|Neoplasm of Trigeminal Nerve|Neoplasm of the Fifth Cranial Nerve|Neoplasm of the Trigeminal Nerve|Neoplasms, Cranial Nerve V|Trigeminal Nerve Neoplasms|Trigeminal Nerve Tumor|Trigeminal Nerve Tumors|Tumor of Fifth Cranial Nerve|Tumor of Trigeminal Nerve|Tumor of the Fifth Cranial Nerve|Tumor of the Trigeminal Nerve|Tumors, Cranial Nerve V	Benign and malignant neoplasms which arise from or metastasize to the trigeminal or fifth cranial nerve which provides sensory innervation to the face, oral cavity and sinuses and the muscles of mastication. Clinical features may include facial pain or sensory loss or weakness of jaw closure. f optic nerve tumors or optic gliomas.  Histologic types include trigeminal neuroma and plexiform neurofibromas. (KEV 8-8-99)
C5123	Anaplastic_Hemispheric_Astrocytoma	Anaplastic_Astrocytoma|Cerebral_Astrocytoma|Malignant_Cerebral_Neoplasm	Anaplastic Hemispheric Astrocytoma|Anaplastic Astrocytic Neoplasm of Cerebral Hemisphere|Anaplastic Astrocytic Neoplasm of the Cerebral Hemisphere|Anaplastic Astrocytic Tumor of Cerebral Hemisphere|Anaplastic Astrocytic Tumor of the Cerebral Hemisphere|Anaplastic Astrocytoma of Cerebral Hemisphere|Anaplastic Astrocytoma of the Cerebral Hemisphere|Anaplastic Astrocytoma, Hemispheric|Anaplastic Cerebral Hemisphere Astrocytic Neoplasm|Anaplastic Hemispheric Astrocytic Neoplasm|Anaplastic Hemispheric Astrocytic Tumor|Cerebral Hemisphere Anaplastic Astrocytoma|Grade III Astrocytic Neoplasm of Cerebral Hemisphere|Grade III Astrocytic Neoplasm of the Cerebral Hemisphere|Grade III Astrocytic Tumor of Cerebral Hemisphere|Grade III Astrocytic Tumor of the Cerebral Hemisphere|Grade III Astrocytoma of Cerebral Hemisphere|Grade III Astrocytoma of the Cerebral Hemisphere|Grade III Cerebral Hemisphere Astrocytic Neoplasm|Grade III Cerebral Hemisphere Astrocytic Tumor|Grade III Cerebral Hemisphere Astrocytoma|Grade III Hemispheric Astrocytic Neoplasm|Grade III Hemispheric Astrocytic Tumor|Grade III Hemispheric Astrocytoma|Hemispheric Anaplastic Astrocytoma|Undifferentiated Astrocytic Neoplasm of Cerebral Hemisphere|Undifferentiated Astrocytic Neoplasm of the Cerebral Hemisphere|Undifferentiated Astrocytic Tumor of Cerebral Hemisphere|Undifferentiated Astrocytic Tumor of the Cerebral Hemisphere|Undifferentiated Astrocytoma of Cerebral Hemisphere|Undifferentiated Astrocytoma of the Cerebral Hemisphere|Undifferentiated Cerebral Hemisphere Astrocytic Neoplasm|Undifferentiated Hemispheric Astrocytic Neoplasm|Undifferentiated Hemispheric Astrocytic Tumor|Undifferentiated Hemispheric Astrocytoma
C5124	Anaplastic_Diencephalic_Astrocytoma	Anaplastic_Astrocytoma|Diencephalic_Astrocytoma|Malignant_Diencephalic_Neoplasm	Anaplastic Diencephalic Astrocytoma|Anaplastic Astrocytic Neoplasm of Diencephalon|Anaplastic Astrocytic Neoplasm of the Diencephalon|Anaplastic Astrocytic Tumor of Diencephalon|Anaplastic Astrocytic Tumor of the Diencephalon|Anaplastic Astrocytoma of Diencephalon|Anaplastic Astrocytoma of the Diencephalon|Anaplastic Diencephalic Astrocytic Neoplasm|Anaplastic Diencephalic Astrocytic Tumor|Diencephalic Anaplastic Astrocytoma|Grade III Astrocytic Neoplasm of Diencephalon|Grade III Astrocytic Neoplasm of the Diencephalon|Grade III Astrocytic Tumor of Diencephalon|Grade III Astrocytic Tumor of the Diencephalon|Grade III Astrocytoma of Diencephalon|Grade III Astrocytoma of the Diencephalon|Grade III Diencephalic Astrocytic Neoplasm|Grade III Diencephalic Astrocytic Tumor|Grade III Diencephalic Astrocytoma|Undifferentiated Astrocytic Neoplasm of Diencephalon|Undifferentiated Astrocytic Neoplasm of the Diencephalon|Undifferentiated Astrocytic Tumor of Diencephalon|Undifferentiated Astrocytic Tumor of the Diencephalon|Undifferentiated Astrocytoma of Diencephalon|Undifferentiated Astrocytoma of the Diencephalon|Undifferentiated Diencephalic Astrocytic Neoplasm|Undifferentiated Diencephalic Astrocytic Tumor|Undifferentiated Diencephalic Astrocytoma
C5125	Diencephalic_Neoplasm	Supratentorial_Neoplasm	Diencephalic Neoplasm|Diencephalic Neoplasms|Diencephalic Tumor|Neoplasm of Diencephalon|Neoplasm of the Diencephalon|Tumor of Diencephalon|Tumor of the Diencephalon
C5126	Malignant_Diencephalic_Neoplasm	Diencephalic_Neoplasm|Malignant_Supratentorial_Neoplasm	Malignant Diencephalic Neoplasm|Malignant Diencephalic Neoplasms|Malignant Diencephalic Tumor
C5127	Benign_Diencephalic_Neoplasm	Benign_Supratentorial_Neoplasm|Diencephalic_Neoplasm	Benign Diencephalic Neoplasm|Benign Diencephalic Neoplasms|Benign Diencephalic Tumor|Benign Neoplasm of Diencephalon|Benign Neoplasm of the Diencephalon|Benign Tumor of Diencephalon|Benign Tumor of the Diencephalon
C5128	Diencephalic_Astrocytoma	Astrocytic_Tumor|Diencephalic_Neoplasm	Diencephalic Astrocytoma|Astrocytic Neoplasm of Diencephalon|Astrocytic Neoplasm of the Diencephalon|Astrocytic Tumor of Diencephalon|Astrocytic Tumor of the Diencephalon|Astrocytoma of Diencephalon|Astrocytoma of the Diencephalon|Diencephalic Astrocytic Neoplasm|Diencephalic Astrocytic Tumor|Diencephalic Astrocytomas
C5129	Diencephalic_Glioblastoma	Malignant_Diencephalic_Neoplasm|Supratentorial_Glioblastoma	Diencephalic Glioblastoma|Diencephalic GBM|Diencephalic Glioblastoma Multiforme|Diencephalic Grade IV Astrocytoma|GBM of Diencephalon|GBM of the Diencephalon|Glioblastoma Multiforme of Diencephalon|Glioblastoma Multiforme of the Diencephalon|Grade IV Astrocytic Neoplasm of Diencephalon|Grade IV Astrocytic Neoplasm of the Diencephalon|Grade IV Astrocytic Tumor of Diencephalon|Grade IV Astrocytic Tumor of the Diencephalon|Grade IV Astrocytoma of Diencephalon|Grade IV Astrocytoma of the Diencephalon|Grade IV Astrocytoma, Diencephalon|Grade IV Diencephalic Astrocytic Neoplasm|Grade IV Diencephalic Astrocytic Tumor|Grade IV Diencephalic Astrocytoma
C5130	Adenoid_Cystic_Breast_Carcinoma	Adenoid_Cystic_Carcinoma|Invasive_Breast_Carcinoma	Adenoid Cystic Breast Carcinoma|Adenocystic Breast Carcinoma|Adenocystic Carcinoma of Breast|Adenocystic Carcinoma of the Breast|Adenoid Cystic Carcinoma of Breast|Adenoid Cystic Carcinoma of the Breast|Mammary Adenocystic Carcinoma
C5131	Adult_Central_Nervous_System_Neoplasm	Central_Nervous_System_Neoplasm	Adult Central Nervous System Neoplasm|Adult CNS Neoplasm|Adult CNS Neoplasms|Adult CNS Tumor|Adult CNS Tumors|Adult Central Nervous System Neoplasms|Adult Central Nervous System Tumor|Adult Central Nervous System Tumors|Neoplasm of Adult CNS|Neoplasm of Adult Central Nervous System|Neoplasm of the Adult CNS|Neoplasm of the Adult Central Nervous System|Tumor of Adult CNS|Tumor of Adult Central Nervous System|Tumor of the Adult CNS|Tumor of the Adult Central Nervous System	Benign and malignant neoplasms which occur in the brain, spinal cord, or meninges of adults.  Astrocytomas, meningiomas, pituitary adenomas, and neurilemomas are the most common primary tumors of the adult period.  Tumor metastases from other organs to the CNS are also more common in adults than in children. (KEV 8-13-99)
C5132	Childhood_Central_Nervous_System_Neoplasm	Central_Nervous_System_Neoplasm|Childhood_Neoplasm	Childhood Central Nervous System Neoplasm|Childhood CNS Neoplasm|Childhood CNS Neoplasms|Childhood CNS Tumor|Childhood CNS Tumors|Childhood Central Nervous System Neoplasms|Childhood Central Nervous System Tumor|Childhood Central Nervous System Tumors|Childhood Neoplasm of CNS|Childhood Neoplasm of Central Nervous System|Childhood Neoplasm of the CNS|Childhood Neoplasm of the Central Nervous System|Childhood Tumor of CNS|Childhood Tumor of Central Nervous System|Childhood Tumor of the CNS|Childhood Tumor of the Central Nervous System|Pediatric CNS Neoplasm|Pediatric CNS Tumor|Pediatric Central Nervous System Neoplasm|Pediatric Central Nervous System Tumor|Pediatric Neoplasm of CNS|Pediatric Neoplasm of Central Nervous System|Pediatric Neoplasm of the CNS|Pediatric Neoplasm of the Central Nervous System|Pediatric Tumor of CNS|Pediatric Tumor of Central Nervous System|Pediatric Tumor of the CNS|Pediatric Tumor of the Central Nervous System	Benign and malignant neoplasms which occur in the brain, spinal cord, or meninges of children.  Posterior fossa astrocytomas, optic pathway gliomas, medulloblastomas, ependymomas, craniopharyngiomas, and pineal tumors are relatively common primary tumors of the CNS in children.  (KEV 8-13-99)
C5133	Benign_Intracranial_Meningioma	Benign_Intracranial_Neoplasm|Benign_Meningioma|Intracranial_Meningioma	Benign Intracranial Meningioma
C5134	Intraspinal_Meningioma	Intraspinal_Neoplasm|Meningioma_by_Site	Intraspinal Meningioma|Meningioma of Spinal Canal and Spinal Cord|Meningioma of the Spinal Canal and Spinal Cord|Spinal Canal and Spinal Cord Meningioma
C5135	Intradural_Extramedullary_Spinal_Canal_Neoplasm	Intraspinal_Neoplasm	Intradural Extramedullary Spinal Canal Neoplasm|Intradural Extramedullary Neoplasm of Spinal Canal|Intradural Extramedullary Neoplasm of the Spinal Canal|Intradural Extramedullary Spinal Canal Tumor|Intradural Extramedullary Spinal Canal Tumors|Intradural Extramedullary Spinal Neoplasms|Intradural Extramedullary Spinal Tumors|Intradural Extramedullary Tumor of Spinal Canal|Intradural Extramedullary Tumor of the Spinal Canal	Neoplasms that occur within the spinal canal in the space between the spinal cord and the dura mater.  The majority of neoplasms in this location are meningiomas or neurofibromas, although neurofibromas, sarcomas, dermoid tumors, ganglioneuromas, hemangiopericytomas, paragangliomas, osteochondromas, lipomas and other neoplasms may also occur in this location.  These tumors may present with local and radicular pain, weakness and/or spinal cord compression.  (From Schutta, Spinal Tumors, in Clinical Neurology, Ch44, pp3-4, 1994)
C5136	Childhood_Glioblastoma	Childhood_Astrocytic_Tumor|Glioblastoma	Childhood Glioblastoma|Astrocytoma, Grade IV Childhood|Childhood Glioblastoma Multiforme|Grade IV Childhood Astrocytic Neoplasm|Grade IV Childhood Astrocytic Tumor|Grade IV Childhood Astrocytoma|Grade IV Pediatric Astrocytic Neoplasm|Grade IV Pediatric Astrocytic Tumor|Grade IV Pediatric Astrocytoma|Pediatric Glioblastoma Multiforme
C5137	Intraductal_Non-Comedo_Breast_Adenocarcinoma	Ductal_Carcinoma_in_situ_of_the_Breast	Intraductal Non-Comedo Breast Adenocarcinoma|Non-Comedo Breast Ductal Carcinoma in situ|Non-Comedo DCIS of Breast|Non-Comedo DCIS of the Breast|Non-Comedo Ductal Carcinoma in situ of Breast|Non-Comedo Ductal Carcinoma in situ of the Breast|Non-Infiltrating Non-Comedo Ductal Breast Carcinoma|Non-Infiltrating Non-Comedo Ductal Carcinoma of Breast|Non-Infiltrating Non-Comedo Ductal Carcinoma of the Breast|Non-Invasive Non-Comedo Ductal Breast Carcinoma|Non-Invasive Non-Comedo Ductal Carcinoma of Breast|Non-Invasive Non-Comedo Ductal Carcinoma of the Breast
C5138	Intraductal_Cribriform_Breast_Adenocarcinoma	Cribriform_Carcinoma|Ductal_Carcinoma_in_situ_of_the_Breast	Intraductal Cribriform Breast Adenocarcinoma|Cribriform DCIS of Breast|Cribriform DCIS of the Breast|Cribriform Ductal Breast Carcinoma in situ|Cribriform Ductal Carcinoma in situ of Breast|Cribriform Ductal Carcinoma in situ of the Breast|DCIS of Breast with Cribriform Pattern|DCIS of the Breast with Cribriform Pattern|Ductal Carcinoma in situ of Breast with Cribriform Pattern|Ductal Carcinoma in situ of the Breast with Cribriform Pattern|Non-Infiltrating Cribriform Ductal Breast Carcinoma|Non-Invasive Cribriform Ductal Breast Carcinoma
C5139	Intraductal_Micropapillary_Breast_Carcinoma	Intraductal_Papillary_Breast_Carcinoma	Intraductal Micropapillary Breast Carcinoma|Micropapillary DCIS of Breast|Micropapillary DCIS of the Breast|Micropapillary Ductal Breast Carcinoma in situ|Micropapillary Ductal Carcinoma in situ of Breast|Micropapillary Ductal Carcinoma in situ of the Breast|Non-Infiltrating Micropapillary Breast Carcinoma|Non-Infiltrating Micropapillary Carcinoma of Breast|Non-Infiltrating Micropapillary Carcinoma of the Breast|Non-Infiltrating Micropapillary Ductal Breast Carcinoma|Non-Infiltrating Micropapillary Ductal Carcinoma of Breast|Non-Infiltrating Micropapillary Ductal Carcinoma of the Breast|Non-Invasive Micropapillary Breast Carcinoma|Non-Invasive Micropapillary Carcinoma of Breast|Non-Invasive Micropapillary Carcinoma of the Breast|Non-Invasive Micropapillary Ductal Breast Carcinoma|Non-Invasive Micropapillary Ductal Carcinoma of Breast|Non-Invasive Micropapillary Ductal Carcinoma of the Breast
C5140	Apocrine_Breast_Carcinoma_in_situ	Apocrine_Ductal_Breast_Carcinoma	Apocrine Breast Carcinoma In Situ|Apocrine Carcinoma in situ of Breast|Apocrine Carcinoma in situ of the Breast|Breast Apocrine Carcinoma in situ
C5141	Apocrine_Ductal_Breast_Carcinoma	Apocrine_Carcinoma|Breast_Adenocarcinoma	Apocrine Breast Carcinoma|Apocrine Carcinoma of Breast|Apocrine Carcinoma of the Breast|Breast Apocrine Carcinoma
C5142	Invasive_Cribriform_Breast_Carcinoma	Breast_Adenocarcinoma|Cribriform_Carcinoma|Invasive_Breast_Carcinoma	Invasive Cribriform Breast Carcinoma|Infiltrating Cribriform Breast Carcinoma|Infiltrating Cribriform Carcinoma of Breast|Infiltrating Cribriform Carcinoma of the Breast|Infiltrating Cribriform Ductal Carcinoma of Breast|Invasive Cribriform Carcinoma of Breast|Invasive Cribriform Carcinoma of the Breast|Invasive Cribriform Ductal Carcinoma of Breast
C5143	Malignant_Breast_Adenomyoepithelioma	Adenomyoepithelioma|Malignant_Breast_Neoplasm	Malignant Breast Adenomyoepithelioma|Breast Adenomyoepithelioma with Malignant Change|Malignant Adenomyoepithelioma of Breast|Malignant Adenomyoepithelioma of the Breast
C5144	Benign_Breast_Adenomyoepithelioma	Adenomyoepithelioma|Benign_Breast_Neoplasm	Benign Breast Adenomyoepithelioma|Benign Adenomyoepithelioma of Breast|Benign Adenomyoepithelioma of the Breast
C5145	Spinal_Cord_Neurofibroma	Benign_Spinal_Cord_Neoplasm|Neurofibroma	Spinal Cord Neurofibroma|Neurofibroma of Spinal Cord
C5146	Cerebellar_Hemangioblastoma	Hemangioblastoma_of_the_Central_Nervous_System	Cerebellar Capillary Hemangioblastoma|Angioblastoma of Cerebellum|Angioblastoma of the Cerebellum|Cerebellar Angioblastoma|Cerebellar Hemangioblastoma|Hemangioblastoma of Cerebellum|Hemangioblastoma of the Cerebellum
C5147	Brain_Stem_Hemangioblastoma	Hemangioblastoma_of_the_Central_Nervous_System	Brain Stem Capillary Hemangioblastoma|Angioblastoma of Brain Stem|Angioblastoma of Brainstem|Angioblastoma of the Brain Stem|Angioblastoma of the Brainstem|Brain Stem Angioblastoma|Brain Stem Hemangioblastoma|Brainstem Angioblastoma|Hemangioblastoma of Brain Stem|Hemangioblastoma of Brainstem|Hemangioblastoma of the Brain Stem|Hemangioblastoma of the Brainstem
C5148	Infratentorial_Glioblastoma	Brain_Glioblastoma|Malignant_Infratentorial_Neoplasm	Infratentorial Glioblastoma|Grade IV Infratentorial Astrocytic Neoplasm|Grade IV Infratentorial Astrocytic Tumor|Grade IV Infratentorial Astrocytoma|Infratentorial Glioblastoma Multiforme
C5149	Supratentorial_Glioblastoma	Brain_Glioblastoma|Malignant_Supratentorial_Neoplasm	Supratentorial Glioblastoma|Grade IV Supratentorial Astrocytic Neoplasm|Grade IV Supratentorial Astrocytic Tumor|Grade IV Supratentorial Astrocytoma|Supratentorial Glioblastoma Multiforme
C5150	Cerebellar_Glioblastoma	Infratentorial_Glioblastoma	Cerebellar Glioblastoma|Cerebellar Glioblastoma Multiforme|Glioblastoma of Cerebellum|Glioblastoma of the Cerebellum|Grade IV Astrocytic Neoplasm of Cerebellum|Grade IV Astrocytic Neoplasm of the Cerebellum|Grade IV Astrocytic Tumor of Cerebellum|Grade IV Astrocytic Tumor of the Cerebellum|Grade IV Astrocytoma of Cerebellum|Grade IV Astrocytoma of the Cerebellum|Grade IV Cerebellar Astrocytic Neoplasm|Grade IV Cerebellar Astrocytic Tumor|Grade IV Cerebellar Astrocytoma
C5151	Cerebral_Glioblastoma	Malignant_Cerebral_Neoplasm|Supratentorial_Glioblastoma	Cerebral Glioblastoma|Cerebral Glioblastoma Multiforme|Cerebral Hemisphere Glioblastoma Multiforme|Glioblastoma Multiforme of Cerebral Hemisphere|Glioblastoma Multiforme of the Cerebral Hemisphere|Grade IV Astrocytic Neoplasm of Cerebral Hemisphere|Grade IV Astrocytic Neoplasm of the Cerebral Hemisphere|Grade IV Astrocytic Tumor of Cerebral Hemisphere|Grade IV Astrocytic Tumor of the Cerebral Hemisphere|Grade IV Astrocytoma of Cerebral Hemisphere|Grade IV Astrocytoma of the Cerebral Hemisphere|Grade IV Cerebral Hemisphere Astrocytic Neoplasm|Grade IV Cerebral Hemisphere Astrocytic Tumor|Grade IV Cerebral Hemisphere Astrocytoma|Grade IV Hemispheric Astrocytic Neoplasm|Grade IV Hemispheric Astrocytic Tumor|Grade IV Hemispheric Astrocytoma|Hemispheric Glioblastoma Multiforme
C5152	Spinal_Cord_Sarcoma	Central_Nervous_System_Sarcoma|Malignant_Spinal_Cord_Neoplasm	Spinal Cord Sarcoma|Sarcoma of Spinal Cord|Sarcoma of the Spinal Cord
C5153	Central_Nervous_System_Sarcoma	Malignant_Central_Nervous_System_Soft_Tissue_Neoplasm|Soft_Tissue_Sarcoma	Central Nervous System Sarcoma|CNS Sarcoma|Sarcoma of CNS|Sarcoma of Central Nervous System|Sarcoma of the CNS|Sarcoma of the Central Nervous System
C5154	Brain_Sarcoma	Central_Nervous_System_Sarcoma|Malignant_Brain_Neoplasm	Brain Sarcoma|Sarcoma of Brain|Sarcoma of the Brain
C5155	Spinal_Cord_Neuroblastoma	Extracranial_Neuroblastoma|Spinal_Cord_Primitive_Neuroectodermal_Neoplasm	Spinal Cord Neuroblastoma|Neuroblastoma of Spinal Cord|Neuroblastoma of the Spinal Cord
C5156	Spinal_Chordoma	Chordoma	Spinal Chordoma|Chordoma of Spinal Column|Chordoma of Spine|Chordoma of the Spinal Column|Spinal Chordomas|Spinal Column Chordoma
C5157	Spinal_Cord_Lymphoma	Central_Nervous_System_Lymphoma|Malignant_Spinal_Cord_Neoplasm	Spinal Cord Lymphoma|Lymphoma of Spinal Cord|Lymphoma of the Spinal Cord|Primary Spinal Cord Lymphoma
C5158	Spinal_Cord_Melanoma	Central_Nervous_System_Melanoma|Malignant_Spinal_Cord_Neoplasm	Spinal Cord Melanoma|Melanoma of Spinal Cord|Melanoma of the Spinal Cord
C5160	Mixed_Lobular_and_Ductal_Breast_Carcinoma	Breast_Adenocarcinoma	Mixed Lobular and Ductal Breast Carcinoma|Ductal and Lobular Carcinoma|Mixed Ductal and Lobular Breast Carcinoma|Mixed Ductal and Lobular Carcinoma of Breast|Mixed Ductal and Lobular Carcinoma of the Breast|Mixed Lobular and Ductal Carcinoma|Mixed Lobular and Ductal Carcinoma of Breast|Mixed Lobular and Ductal Carcinoma of the Breast
C5161	Undifferentiated_Breast_Carcinoma	Invasive_Breast_Carcinoma|Undifferentiated_Carcinoma	Undifferentiated Breast Carcinoma|Undifferentiated Carcinoma of Breast|Undifferentiated Carcinoma of the Breast
C5163	Breast_Adenocarcinoma_with_Squamous_Metaplasia	Adenocarcinoma_with_Squamous_Metaplasia|Breast_Adenocarcinoma|Invasive_Breast_Carcinoma	Breast Adenocarcinoma with Squamous Metaplasia|Adenoacanthoma of Breast|Adenoacanthoma of the Breast|Adenocarcinoma of Breast with Squamous Metaplasia|Adenocarcinoma of the Breast with Squamous Metaplasia|Breast Adenoacanthoma
C5164	Metaplastic_Breast_Carcinoma	Invasive_Breast_Carcinoma	Metaplastic Breast Carcinoma|Metaplastic Carcinoma of Breast|Metaplastic Carcinoma of the Breast
C5165	Childhood_Lymphoma	Childhood_Hematopoietic_Neoplasm|Lymphoma	Childhood Lymphoma|Pediatric Lymphoma
C5166	Mucoepidermoid_Breast_Carcinoma	Metaplastic_Breast_Carcinoma|Mucoepidermoid_Carcinoma	Mucoepidermoid Breast Carcinoma|Mucoepidermoid Carcinoma of Breast|Mucoepidermoid Carcinoma of the Breast	A carcinoma of the breast characterized by pools of mucin and islands of malignant squamous cells.  Mucoepidermoid carcinomas of the breast are extremely rare. --2003
C5167	High-Grade_Mucoepidermoid_Breast_Carcinoma	Mucoepidermoid_Breast_Carcinoma	High Grade Mucoepidermoid Breast Carcinoma|High-Grade Mucoepidermoid Carcinoma of Breast|High-Grade Mucoepidermoid Carcinoma of the Breast
C5168	Low-Grade_Mucoepidermoid_Breast_Carcinoma	Mucoepidermoid_Breast_Carcinoma	Low Grade Mucoepidermoid Breast Carcinoma|Low-Grade Mucoepidermoid Carcinoma of Breast|Low-Grade Mucoepidermoid Carcinoma of the Breast
C5169	Breast_Neuroendocrine_Neoplasm	Breast_Neoplasm|Neuroendocrine_Neoplasm	Breast Neuroendocrine Neoplasm|Breast Neuroendocrine Tumor|Neuroendocrine Neoplasm of Breast|Neuroendocrine Neoplasm of the Breast|Neuroendocrine Tumor of Breast|Neuroendocrine Tumor of the Breast
C5170	Carcinoid_Tumor_of_the_Breast	Breast_Neuroendocrine_Neoplasm|Carcinoid_Tumor	Carcinoid Tumor of the Breast|Breast Carcinoid|Breast Carcinoid Neoplasm|Breast Carcinoid Tumor|Carcinoid Breast Tumor|Carcinoid Neoplasm of Breast|Carcinoid Neoplasm of the Breast|Carcinoid Tumor of Breast|Carcinoid of Breast|Carcinoid of the Breast|Mammary Carcinoid Neoplasm|Mammary Carcinoid Tumor
C5171	Metastatic_Breast_Carcinoid_Tumor	Carcinoid_Tumor_of_the_Breast|Metastatic_Carcinoid_Tumor	Metastatic Breast Carcinoid Tumor|Metastatic Breast Carcinoid Neoplasm|Metastatic Carcinoid Breast Tumor|Metastatic Carcinoid Neoplasm of Breast|Metastatic Carcinoid Neoplasm of the Breast|Metastatic Carcinoid Tumor of Breast|Metastatic Carcinoid Tumor of the Breast
C5173	Primary_Breast_Carcinoid_Tumor	Carcinoid_Tumor_of_the_Breast	Primary Breast Carcinoid Tumor|Primary Breast Carcinoid Neoplasm|Primary Carcinoid Breast Tumor|Primary Carcinoid Neoplasm of Breast|Primary Carcinoid Neoplasm of the Breast|Primary Carcinoid Tumor of Breast|Primary Carcinoid Tumor of the Breast
C5174	Breast_Apocrine_Carcinoma	Retired_Concepts	Apocrine Breast Carcinoma|Apocrine Carcinoma of Breast|Apocrine Carcinoma of the Breast|Apocrine Ductal Carcinoma of Breast|Breast Apocrine Carcinoma|Oncocytic Breast Carcinoma|Oncocytic Carcinoma of Breast|Oncocytic Carcinoma of the Breast
C5175	Signet_Ring_Cell_Breast_Carcinoma	Breast_Adenocarcinoma|Invasive_Breast_Carcinoma|Signet_Ring_Cell_Carcinoma	Signet Ring Cell Breast Carcinoma|Mammary Signet Ring Cell Carcinoma|Primary Mammary Signet Ring Cell Carcinoma|Primary SRC Breast Carcinoma|Primary SRC Carcinoma of Breast|Primary SRC Carcinoma of the Breast|Primary Signet Ring Cell Breast Carcinoma|Primary Signet Ring Cell Carcinoma of Breast|Primary Signet Ring Cell Carcinoma of the Breast|SRC Breast Carcinoma|SRC Carcinoma of Breast|SRC Carcinoma of the Breast|Signet Ring Cell Carcinoma of Breast|Signet Ring Cell Carcinoma of the Breast
C5176	Metastatic_Signet_Ring_Cell_Breast_Carcinoma	Signet_Ring_Cell_Breast_Carcinoma	Metastatic Signet Ring Cell Breast Carcinoma|Metastatic Mammary Signet Ring Cell Carcinoma|Metastatic SRC Breast Carcinoma|Metastatic SRC Carcinoma of Breast|Metastatic SRC Carcinoma of the Breast|Metastatic Signet Ring Cell Carcinoma of Breast|Metastatic Signet Ring Cell Carcinoma of the Breast
C5177	Squamous_Cell_Breast_Carcinoma	Metaplastic_Breast_Carcinoma|Squamous_Cell_Carcinoma	Squamous Cell Breast Carcinoma|SCC of Breast|SCC of the Breast|Squamous Breast Carcinoma|Squamous Carcinoma of Breast|Squamous Carcinoma of the Breast|Squamous Cell Carcinoma of Breast|Squamous Cell Carcinoma of the Breast
C5178	Metastatic_Squamous_Cell_Breast_Carcinoma	Metastatic_Squamous_Cell_Carcinoma|Squamous_Cell_Breast_Carcinoma	Metastatic Squamous Cell Breast Carcinoma|Metastatic Squamous Cell Carcinoma of Breast|Metastatic Squamous Cell Carcinoma of the Breast
C5179	Primary_Squamous_Cell_Breast_Carcinoma	Squamous_Cell_Breast_Carcinoma	Primary Squamous Cell Breast Carcinoma|Primary Squamous Cell Carcinoma of Breast|Primary Squamous Cell Carcinoma of the Breast
C5180	Malignant_Breast_Eccrine_Spiradenoma	Malignant_Breast_Neoplasm|Malignant_Eccrine_Spiradenoma	Malignant Breast Eccrine Spiradenoma|Malignant Eccrine Spiradenoma of Breast|Malignant Eccrine Spiradenoma of the Breast
C5181	Primary_Non-Hodgkin_s_Breast_Lymphoma	Breast_Lymphoma|Non-Hodgkin_s_Lymphoma	Primary Non-Hodgkin's Breast Lymphoma|Primary Non-Hodgkin Breast Lymphoma|Primary Non-Hodgkin Lymphoma of Breast|Primary Non-Hodgkin Lymphoma of the Breast|Primary Non-Hodgkin's Lymphoma of Breast|Primary Non-Hodgkin's Lymphoma of the Breast
C5182	Primary_T-Cell_Breast_Lymphoma	Primary_Non-Hodgkin_s_Breast_Lymphoma|T-Cell_Non-Hodgkin_s_Lymphoma	Primary T-Cell Breast Lymphoma|Primary T-Cell Lymphoma of Breast|Primary T-Cell Lymphoma of the Breast
C5183	Hereditary_Multiple_Exostoses	Exostosis|Hereditary_Neoplastic_Syndrome	Hereditary Multiple Exostoses	Hereditary disorder transmitted by autosomal dominant genes (EXT1-3) and characterized by multiple exostoses (multiple osteochondromas) near the ends of long bones.  The genetic abnormality results in a defect in the osteoclastic activity at the metaphyseal ends of the bone during the remodeling process in childhood or early adolescence.  The metaphyses develop benign, bony outgrowths often capped by cartilage. A small number undergo neoplastic transformation.
C5184	Breast_Angiosarcoma	Angiosarcoma|Breast_Sarcoma|Vascular_Breast_Neoplasm	Breast Angiosarcoma|Angiosarcoma of Breast|Angiosarcoma of the Breast|Breast Hemangiosarcoma|Hemangiosarcoma of Breast|Hemangiosarcoma of the Breast
C5185	Breast_Fibrosarcoma	Breast_Sarcoma|Soft_Tissue_Fibrosarcoma	Breast Fibrosarcoma|Fibrosarcoma of Breast|Fibrosarcoma of the Breast
C5186	Breast_Leiomyosarcoma	Breast_Sarcoma|Leiomyosarcoma	Breast Leiomyosarcoma|Leiomyosarcoma of Breast|Leiomyosarcoma of the Breast
C5187	Breast_Liposarcoma	Breast_Sarcoma|Liposarcoma	Breast Liposarcoma|Liposarcoma of Breast|Liposarcoma of the Breast
C5189	Osteosarcoma_of_the_Breast	Breast_Sarcoma|Extraskeletal_Osteosarcoma	Breast Osteosarcoma|Osteogenic Breast Sarcoma|Osteogenic Sarcoma of Breast|Osteogenic Sarcoma of the Breast|Osteosarcoma of Breast|Osteosarcoma of the Breast
C5190	Breast_Rhabdomyosarcoma	Breast_Sarcoma|Rhabdomyosarcoma	Breast Rhabdomyosarcoma|Rhabdomyosarcoma of Breast|Rhabdomyosarcoma of the Breast
C5193	Benign_Eccrine_Breast_Spiradenoma	Benign_Breast_Neoplasm|Benign_Eccrine_Spiradenoma	Benign Breast Eccrine Spiradenoma|Benign Eccrine Breast Spiradenoma|Benign Eccrine Spiradenoma of Breast|Benign Eccrine Spiradenoma of the Breast
C5194	Complex_Breast_Fibroadenoma	Fibroadenoma	Complex Fibroadenoma|Complex Fibroadenoma of Breast|Complex Fibroadenoma of the Breast
C5195	Atypical_Hyperplasia_of_the_Breast	Atypical_Hyperplasia|Breast_Hyperplasia	Atypical Hyperplasia of the Breast|Atypical Breast Hyperplasia|Atypical Hyperplasia of Breast
C5196	Benign_Phyllodes_Tumor_of_the_Breast	Benign_Breast_Neoplasm|Benign_Phyllodes_Tumor|Phyllodes_Tumor_of_the_Breast	Benign Breast Phyllodes Tumor|Benign Phyllodes Neoplasm of Breast|Benign Phyllodes Neoplasm of the Breast|Benign Phyllodes Tumor of Breast|Benign Phyllodes Tumor of the Breast|Breast Benign Phyllodes Neoplasm
C5197	Benign_Nipple_Neoplasm	Nipple_Neoplasm	Benign Nipple Neoplasm|Benign Neoplasm of Nipple|Benign Neoplasm of the Nipple|Benign Nipple Tumor|Benign Tumor of Nipple|Benign Tumor of the Nipple
C5198	Apocrine_Breast_Adenosis	Breast_Adenosis|Breast_Fibrocystic_Change_Non-Proliferative_Type	Breast Apocrine Adenosis|Apocrine Adenosis of Breast|Apocrine Adenosis of the Breast
C5199	Microglandular_Breast_Adenosis	Breast_Adenosis	Breast Microglandular Adenosis|Microglandular Adenosis of Breast|Microglandular Adenosis of the Breast
C5200	Papillary_Ductal_Breast_Hyperplasia	Ductal_Breast_Hyperplasia	Papillary Ductal Breast Hyperplasia|Papillary Breast Hyperplasia|Papillary Duct Hyperplasia of Breast|Papillary Duct Hyperplasia of the Breast|Papillary Hyperplasia of Breast|Papillary Hyperplasia of the Breast
C5201	Intraductal_Breast_Papillomatosis	Breast_Papillomatosis|Intraductal_Papillomatosis	Intraductal Breast Papillomatosis|Intraductal Papillomatosis of Breast|Intraductal Papillomatosis of the Breast
C5203	Non-Proliferating_Breast_Lesion	Benign_Breast_Neoplasm	Non-Proliferating Breast Lesion|Non-Proliferating Lesion of Breast|Non-Proliferating Lesion of the Breast
C5204	Proliferating_Breast_Lesion_without_Atypia	Breast_Fibrocystic_Change_Proliferative_Type	Proliferating Breast Lesion without Atypia|Proliferating Lesion of Breast without Atypia|Proliferating Lesion of the Breast without Atypia
C5205	Sclerosing_Adenosis_of_the_Breast	Breast_Adenosis|Breast_Fibrocystic_Change_Proliferative_Type	Breast Sclerosing Adenosis|Sclerosing Adenosis of Breast|Sclerosing Adenosis of the Breast|Sclerosing Breast Adenosis
C5206	Papillary_Breast_Neoplasm	Breast_Neoplasm|Papillary_Epithelial_Neoplasm	Papillary Breast Neoplasm|Papillary Breast Tumor|Papillary Neoplasm of Breast|Papillary Neoplasm of the Breast|Papillary Tumor of Breast|Papillary Tumor of the Breast
C5209	Vascular_Breast_Neoplasm	Breast_Soft_Tissue_Neoplasm|Vascular_Neoplasm	Vascular Breast Neoplasm|Vascular Breast Tumor|Vascular Neoplasm of Breast|Vascular Neoplasm of the Breast|Vascular Tumor of Breast|Vascular Tumor of the Breast
C5210	Breast_Capillary_Hemangioma	Breast_Hemangioma|Capillary_Hemangioma	Breast Capillary Hemangioma|Breast Capillary Angioma|Capillary Angioma of Breast|Capillary Angioma of the Breast|Capillary Hemangioma of Breast|Capillary Hemangioma of the Breast
C5211	Breast_Epithelioid_Hemangioma	Breast_Hemangioma	Breast Epithelioid Hemangioma|Breast Histiocytoid Hemangioma|Epithelioid Breast Hemangioma|Epithelioid Hemangioma of Breast|Epithelioid Hemangioma of the Breast|Histiocytoid Breast Hemangioma|Histiocytoid Hemangioma of Breast|Histiocytoid Hemangioma of the Breast
C5212	Nipple_Neoplasm	Breast_Neoplasm	Nipple Neoplasm|Neoplasm of Nipple|Neoplasm of the Nipple|Nipple Tumor|Tumor of Nipple|Tumor of the Nipple
C5213	Malignant_Nipple_Neoplasm	Malignant_Breast_Neoplasm|Nipple_Neoplasm	Malignant Nipple Neoplasm|Malignant Neoplasm of Nipple|Malignant Neoplasm of the Nipple|Malignant Nipple Tumor|Malignant Tumor of Nipple|Malignant Tumor of the Nipple
C5214	Breast_Adenocarcinoma	Adenocarcinoma|Breast_Carcinoma	Breast Adenocarcinoma|Adenocarcinoma of Breast|Adenocarcinoma of the Breast|Mammary adenocarcinoma
C5215	Complex_Ovarian_Cyst	Benign_Ovarian_Cyst	Complex Ovarian Cyst|Complex Cyst of Ovary|Complex Cyst of the Ovary|Complex Cystic Neoplasm of Ovary|Complex Cystic Neoplasm of the Ovary|Complex Cystic Ovarian Neoplasm|Complex Cystic Ovarian Tumor|Complex Cystic Tumor of Ovary|Complex Cystic Tumor of the Ovary
C5216	Functional_Ovarian_Cyst	Simple_Ovarian_Cyst	Functional Ovarian Cyst|Functional Cyst of Ovary|Functional Cyst of the Ovary
C5217	Retention_Ovarian_Cyst	Simple_Ovarian_Cyst	Retention Ovarian Cyst|Retention Cyst of Ovary|Retention Cyst of the Ovary
C5218	Unilocular_Ovarian_Cyst	Benign_Ovarian_Cyst	Unilocular Ovarian Cyst|Unilocular Cyst of Ovary|Unilocular Cyst of the Ovary
C5219	Benign_Ovarian_Thecoma	Benign_Ovarian_Sex_Cord-Stromal_Tumor|Thecoma	Benign Ovarian Thecoma|Benign Ovarian Thecal Cell Neoplasm|Benign Ovarian Thecal Cell Tumor|Benign Thecal Cell Neoplasm of Ovary|Benign Thecal Cell Neoplasm of the Ovary|Benign Thecal Cell Tumor of Ovary|Benign Thecal Cell Tumor of the Ovary|Benign Thecoma of Ovary|Benign Thecoma of the Ovary
C5220	Stage_IA_Ovarian_Cancer	Stage_I_Ovarian_Cancer	Stage IA Ovarian Cancer|AJCC Stage IA Ovarian Cancer|FIGO Stage IA Cancer of Ovary|FIGO Stage IA Cancer of the Ovary|FIGO Stage IA Carcinoma of Ovary|FIGO Stage IA Carcinoma of the Ovary|FIGO Stage IA Ovarian Cancer|FIGO Stage IA Ovarian Carcinoma|Ovarian Cancer Stage IA	Stage IA includes: T1a, N0, M0.  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C5221	Stage_IB_Ovarian_Cancer	Stage_I_Ovarian_Cancer	Stage IB Ovarian Cancer|AJCC Stage IB Ovarian Cancer|FIGO Stage IB Cancer of Ovary|FIGO Stage IB Cancer of the Ovary|FIGO Stage IB Carcinoma of Ovary|FIGO Stage IB Carcinoma of the Ovary|FIGO Stage IB Ovarian Cancer|FIGO Stage IB Ovarian Carcinoma|Ovarian Cancer Stage IB	Stage IB includes: T1b, N0, M0. T1b: Tumor limited to both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C5222	Stage_IC_Ovarian_Cancer	Stage_I_Ovarian_Cancer	Stage IC Ovarian Cancer|AJCC Stage IC Ovarian Cancer|FIGO Stage IC Cancer of Ovary|FIGO Stage IC Cancer of the Ovary|FIGO Stage IC Carcinoma of Ovary|FIGO Stage IC Carcinoma of the Ovary|FIGO Stage IC Ovarian Cancer|FIGO Stage IC Ovarian Carcinoma|Ovarian Cancer Stage IC	Stage IC includes: T1c, N0, M0. T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C5223	Stage_IIA_Ovarian_Cancer	Stage_II_Ovarian_Cancer	Stage IIA Ovarian Cancer|AJCC Stage IIA Ovarian Cancer|FIGO Stage IIA Cancer of Ovary|FIGO Stage IIA Cancer of the Ovary|FIGO Stage IIA Carcinoma of Ovary|FIGO Stage IIA Carcinoma of the Ovary|FIGO Stage IIA Ovarian Cancer|FIGO Stage IIA Ovarian Carcinoma|Ovarian Cancer Stage IIA	Stage IIA includes: T2a, N0, M0.  T2a: Extension and/or implants on uterus and/or tube(s). No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C5224	Stage_IIB_Ovarian_Cancer	Stage_II_Ovarian_Cancer	Stage IIB Ovarian Cancer|AJCC Stage IIB Ovarian Cancer|FIGO Stage IIB Cancer of Ovary|FIGO Stage IIB Cancer of the Ovary|FIGO Stage IIB Carcinoma of Ovary|FIGO Stage IIB Carcinoma of the Ovary|FIGO Stage IIB Ovarian Cancer|FIGO Stage IIB Ovarian Carcinoma|Ovarian Cancer Stage IIB	Stage IIB includes: T2b N0, M0.  T2b: Extension and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C5225	Stage_IIC_Ovarian_Cancer	Stage_II_Ovarian_Cancer	Stage IIC Ovarian Cancer|AJCC Stage IIC Ovarian Cancer|FIGO Stage IIC Cancer of Ovary|FIGO Stage IIC Cancer of the Ovary|FIGO Stage IIC Carcinoma of Ovary|FIGO Stage IIC Carcinoma of the Ovary|FIGO Stage IIC Ovarian Cancer|FIGO Stage IIC Ovarian Carcinoma|Ovarian Cancer Stage IIC	Stage IIC includes: T2c N0, M0. Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washing.  No malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C5226	Borderline_Ovarian_Serous_Neoplasm	Borderline_Ovarian_Epithelial_Neoplasm|Ovarian_Serous_Neoplasm	Borderline Ovarian Serous Tumor|Borderline Ovarian Serous Neoplasm|Borderline Serous Neoplasm of Ovary|Borderline Serous Neoplasm of the Ovary|Borderline Serous Tumor of Ovary|Borderline Serous Tumor of the Ovary|Ovarian Serous Neoplasm of Low Malignant Potential|Ovarian Serous Tumor of Low Malignant Potential|Proliferating Ovarian Serous Neoplasm|Proliferating Ovarian Serous Tumor|Proliferating Serous Neoplasm of Ovary|Proliferating Serous Neoplasm of the Ovary|Proliferating Serous Tumor of Ovary|Proliferating Serous Tumor of the Ovary|Serous Neoplasm of Ovary with Low Malignant Potential|Serous Neoplasm of the Ovary with Low Malignant Potential|Serous Ovarian Neoplasm of Low Malignant Potential|Serous Ovarian Tumor of Low Malignant Potential|Serous Tumor of Ovary with Low Malignant Potential|Serous Tumor of the Ovary with Low Malignant Potential	Borderline ovarian serous neoplasm is a serous neoplasm showing some or all of the features associated with carcinoma but lacking definite stromal invasion. --2002
C5228	Ovarian_Cystadenocarcinoma	Cystadenocarcinoma|Ovarian_Adenocarcinoma	Ovarian Cystadenocarcinoma|Cystadenocarcinoma of Ovary|Cystadenocarcinoma of the Ovary
C5229	Ovarian_Carcinoid_Tumor	Midgut_Carcinoid_Tumor|Ovarian_Monodermal_and_Highly_Specialized_Teratoma|Ovarian_Neuroendocrine_Neoplasm	Ovarian Carcinoid Tumor|Carcinoid Neoplasm of Ovary|Carcinoid Neoplasm of the Ovary|Carcinoid Tumor of Ovary|Carcinoid Tumor of the Ovary|Ovarian Carcinoid Neoplasm
C5230	Ovarian_Stromal_Luteoma	Retired_Concepts	Ovarian Stromal Luteoma|Stromal Luteoma of Ovary|Stromal Luteoma of the Ovary
C5231	Ovarian_Leydig_Cell_Tumor	Leydig_Cell_Tumor|Steroid_Cell_Tumor_of_the_Ovary	Ovarian Leydig Cell Tumor|Leydig Cell Neoplasm of Ovary|Leydig Cell Neoplasm of the Ovary|Leydig Cell Tumor of Ovary|Leydig Cell Tumor of the Ovary|Ovarian Leydig Cell Neoplasm
C5232	Ovarian_Angiosarcoma	Angiosarcoma|Ovarian_Sarcoma	Ovarian Angiosarcoma|Angiosarcoma of Ovary|Angiosarcoma of the Ovary|Hemangiosarcoma of Ovary|Hemangiosarcoma of the Ovary|Ovarian Hemangiosarcoma
C5233	Ovarian_Fibrosarcoma	Malignant_Ovarian_Sex_Cord-Stromal_Tumor|Ovarian_Sarcoma|Soft_Tissue_Fibrosarcoma|Thecoma-Fibroma_Group_Ovarian_Tumor	Ovarian Fibrosarcoma|Fibrosarcoma of Ovary|Fibrosarcoma of the Ovary
C5234	Ovarian_Leiomyosarcoma	Leiomyosarcoma|Ovarian_Sarcoma	Ovarian Leiomyosarcoma|Leiomyosarcoma of Ovary|Leiomyosarcoma of the Ovary
C5235	Ovarian_Myxoid_Liposarcoma	Myxoid_Liposarcoma|Ovarian_Liposarcoma	Ovarian Myxoid Liposarcoma|Myxoid Liposarcoma of Ovary|Myxoid Liposarcoma of the Ovary
C5236	Ovarian_Rhabdomyosarcoma	Ovarian_Sarcoma|Rhabdomyosarcoma	Ovarian Rhabdomyosarcoma|Rhabdomyosarcoma of Ovary|Rhabdomyosarcoma of the Ovary
C5237	Ovarian_Neuroendocrine_Neoplasm	Neuroendocrine_Neoplasm|Ovarian_Neoplasm	Ovarian Neuroendocrine Neoplasm|Neuroendocrine Neoplasm of Ovary|Neuroendocrine Neoplasm of the Ovary|Neuroendocrine Tumor of Ovary|Neuroendocrine Tumor of the Ovary|Ovarian Neuroendocrine Tumor
C5238	Ovarian_Non-Small-Cell_Type_Neuroendocrine_Carcinoma	Large_Cell_Carcinoma|Ovarian_Carcinoma|Ovarian_Neuroendocrine_Neoplasm	Ovarian Large Cell Neuroendocrine Carcinoma|Large Cell Neuroendocrine Carcinoma of Ovary|Large Cell Neuroendocrine Carcinoma of the Ovary|Large-Cell Neuroendocrine Carcinoma of Ovary|Large-Cell Neuroendocrine Carcinoma of the Ovary|Non-Small-Cell Type Neuroendocrine Carcinoma of Ovary|Non-Small-Cell Type Neuroendocrine Carcinoma of the Ovary|Ovarian Non-Small-Cell Type Neuroendocrine Carcinoma
C5240	Ovarian_Transitional_Cell_Carcinoma	Malignant_Ovarian_Transitional_Cell_Tumor|Ovarian_Carcinoma|Transitional_Cell_Carcinoma	Ovarian Transitional Cell Carcinoma|Transitional Cell Carcinoma of Ovary|Transitional Cell Carcinoma of the Ovary
C5241	Mixed_Germ_Cell-Sex_Cord-Stromal_Tumor	Mixed_Neoplasm|Reproductive_Endocrine_Neoplasm|Reproductive_System_Neoplasm	Mixed Germ Cell-Sex Cord-Stromal Tumor|Mixed Germ Cell-Sex Cord Neoplasm|Mixed Germ Cell-Sex Cord Tumor|Mixed Germ Cell-Sex Cord-Stromal Neoplasm
C5242	Ovarian_Mucinous_Neoplasm	Mucinous_Neoplasm|Ovarian_Epithelial_Neoplasm	Ovarian Mucinous Tumor|Mucinous Neoplasm of Ovary|Mucinous Neoplasm of the Ovary|Mucinous Tumor of Ovary|Mucinous Tumor of the Ovary|Ovarian Mucinous Neoplasm	Ovarian mucinous neoplasms are less common than the serous neoplasms and are bilateral in only 10% to 20% of the cases.As with their serous counterpart, they can be divided into benign (mucinous cystadenoma), borderline and malignant (mucinous adenocarcinoma and mucinous cystadenocarcinoma).  Grossly, they tend to grow larger than the serous types and are partially or completely cystic, often multiloculated.  A mucoid material is present in the lumen. --2002
C5243	Ovarian_Mucinous_Adenocarcinoma	Malignant_Ovarian_Mucinous_Tumor|Mucinous_Adenocarcinoma|Ovarian_Adenocarcinoma	Ovarian Mucinous Adenocarcinoma|Mucinous Adenocarcinoma of Ovary|Mucinous Adenocarcinoma of the Ovary|Mucinous Carcinoma of Ovary|Mucinous Carcinoma of the Ovary|Ovarian Mucinous Carcinoma	Ovarian mucinous adenocarcinoma is a mucinous neoplasm characterized by cell atypia, increased layering of cells, greater complexity of glands and papillae (budding, bridging, appearance of solid foci) and areas of stromal invasion. --2002
C5244	Ovarian_Soft_Tissue_Neoplasm	Ovarian_Neoplasm|Soft_Tissue_Neoplasm	Ovarian Soft Tissue Neoplasm|Ovarian Soft Tissue Tumor|Soft Tissue Neoplasm of Ovary|Soft Tissue Neoplasm of the Ovary|Soft Tissue Tumor of Ovary|Soft Tissue Tumor of the Ovary
C5245	Ovarian_Myxoma	Myxoma|Ovarian_Soft_Tissue_Neoplasm	Ovarian Myxoma|Myxoma of Ovary|Myxoma of the Ovary
C5246	Benign_Ovarian_Partly_Luteinized_Thecoma	Benign_Ovarian_Luteinized_Thecoma	Benign Ovarian Partly Luteinized Thecoma|Benign Partly Luteinized Thecoma of Ovary|Benign Partly Luteinized Thecoma of the Ovary|Ovarian Partly Luteinized Theca Cell Neoplasm|Ovarian Partly Luteinized Theca Cell Tumor|Partly Luteinized Theca Cell Neoplasm of Ovary|Partly Luteinized Theca Cell Neoplasm of the Ovary|Partly Luteinized Theca Cell Tumor of Ovary|Partly Luteinized Theca Cell Tumor of the Ovary
C5247	Gastric_Cardia_Adenocarcinoma	Gastric_Adenocarcinoma|Gastric_Cardia_Carcinoma	Gastric Cardia Adenocarcinoma|Adenocarcinoma of Cardia of Stomach|Adenocarcinoma of Gastric Cardia|Adenocarcinoma of the Cardia of the Stomach|Adenocarcinoma of the Gastric Cardia
C5248	Mucinous_Gastric_Adenocarcinoma	Mucinous_Adenocarcinoma|Sporadic_Gastric_Carcinoma	Mucinous Gastric Adenocarcinoma|Mucinous Adenocarcinoma of Stomach|Mucinous Adenocarcinoma of the Stomach|Mucinous Stomach Adenocarcinoma	A variant of gastric adenocarcinoma with more than half of the tumor containing extracellular mucinous pools. -- 2003
C5250	Signet_Ring_Cell_Gastric_Adenocarcinoma	Gastric_Adenocarcinoma	Signet Ring Cell Gastric Adenocarcinoma|Gastric Signet Ring Cell Adenocarcinoma|Signet Ring Cell Adenocarcinoma of Stomach|Signet Ring Cell Adenocarcinoma of the Stomach|Signet Ring Cell Stomach Adenocarcinoma	A variant of gastric adenocarcinoma characterized by malignant cells containing intracytoplasmic mucin.  -- 2003
C5251	Primary_Gastric_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma|Gastric_Non-Hodgkin_s_Lymphoma	Primary Gastric Burkitt's Lymphoma|Primary Burkitt's Lymphoma of Stomach|Primary Burkitt's Lymphoma of the Stomach
C5253	Primary_Gastric_Diffuse_Large_B-Cell_Lymphoma	Diffuse_Large_B-Cell_Lymphoma|Gastric_Non-Hodgkin_s_Lymphoma	Primary Gastric Diffuse Large B-Cell Lymphoma|Primary Diffuse Large B-Cell Gastric Lymphoma|Primary Diffuse Large B-Cell Lymphoma of Stomach|Primary Diffuse Large B-Cell Lymphoma of the Stomach
C5254	Primary_Gastric_T-Cell_Non-Hodgkin_s_Lymphoma	Gastric_Non-Hodgkin_s_Lymphoma|T-Cell_Non-Hodgkin_s_Lymphoma	Primary Gastric T-Cell Non-Hodgkin's Lymphoma|Primary Gastric T-Cell Lymphoma|Primary T-Cell Lymphoma of Stomach|Primary T-Cell Lymphoma of the Stomach
C5256	Immature_Gastric_Teratoma	Gastric_Teratoma|Immature_Extragonadal_Teratoma|Malignant_Gastric_Germ_Cell_Neoplasm	Immature Gastric Teratoma|Malignant Gastric Teratoma|Malignant Teratoma of Stomach|Malignant Teratoma of the Stomach
C5258	Gastric_Lipoma	Benign_Gastric_Mesenchymal_Neoplasm|Lipoma	Gastric Lipoma|Lipoma of Stomach|Lipoma of the Stomach
C5259	Gastric_Teratoma	Gastric_Germ_Cell_Neoplasm|Teratoma	Gastric Teratoma|Teratoma of Stomach|Teratoma of the Stomach
C5260	Mature_Gastric_Teratoma	Gastric_Teratoma|Mature_Teratoma	Mature Gastric Teratoma|Mature Teratoma of Stomach|Mature Teratoma of the Stomach
C5261	Childhood_Acute_Lymphoblastic_Leukemia_in_Partial_Remission	Childhood_Acute_Lymphoblastic_Leukemia_in_Remission	Childhood Acute Lymphoblastic Leukemia in Partial Remission|Childhood Acute Lymphocytic Leukemia in Partial Remission|Childhood Acute Lymphogenous Leukemia in Partial Remission|Childhood Acute Lymphoid Leukemia in Partial Remission|Pediatric Acute Lymphoblastic Leukemia in Partial Remission|Pediatric Acute Lymphocytic Leukemia in Partial Remission|Pediatric Acute Lymphogenous Leukemia in Partial Remission|Pediatric Acute Lymphoid Leukemia in Partial Remission
C5262	Childhood_Acute_Lymphoblastic_Leukemia_in_Complete_Remission	Childhood_Acute_Lymphoblastic_Leukemia_in_Remission	Childhood Acute Lymphoblastic Leukemia in Complete Remission|Childhood Acute Lymphocytic Leukemia in Complete Remission|Childhood Acute Lymphogenous Leukemia in Complete Remission|Childhood Acute Lymphoid Leukemia in Complete Remission|Pediatric Acute Lymphoblastic Leukemia in Complete Remission|Pediatric Acute Lymphocytic Leukemia in Complete Remission|Pediatric Acute Lymphogenous Leukemia in Complete Remission|Pediatric Acute Lymphoid Leukemia in Complete Remission
C5263	Gene_Exchanges	Miscellaneous_Molecular_Biology_Terms	Gene Exchanges
C5264	Bronchial_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue|Lung_Non-Hodgkin_s_Lymphoma	Bronchial Mucosa-Associated Lymphoid Tissue Lymphoma|BALT Lymphoma|BALToma|Bronchial MALT Lymphoma|Bronchus-Associated Lymphoid Tissue Lymphoma
C5265	Thyroid_Lymphoma	Lymphoma_by_Site|Malignant_Thyroid_Neoplasm	Thyroid Gland Lymphoma|Lymphoma of Thyroid|Lymphoma of Thyroid Gland|Lymphoma of the Thyroid|Lymphoma of the Thyroid Gland|Primary Thyroid Gland Lymphoma|Thyroid Lymphoma	A lymphoma primarily involving the thyroid gland.  (NCI05)
C5266	Gastric_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue|Gastric_Non-Hodgkin_s_Lymphoma	Gastric Mucosa-Associated Lymphoid Tissue Lymphoma|Gastric MALT Lymphoma|Gastric MALToma|MALT Lymphoma of Stomach|MALT Lymphoma of the Stomach|MALToma of Stomach|MALToma of the Stomach|Primary Gastric B-Cell MALT Lymphoma|Primary Gastric MALT Lymphoma|Primary MALT Lymphoma of Stomach|Primary MALT Lymphoma of the Stomach	A low grade, indolent B-cell lymphoma, usually associated with Helicobacter Pylori infection.  Morphologically it is characterized by a dense mucosal atypical lymphocytic (centrocyte-like cell) infiltrate with often prominent lymphoepithelial lesions and plasmacytic differentiation.  Approximately 40% of gastric MALT lymphomas carry the t(11;18)(q21;q21).  Such cases are resistant to Helicobacter Pylori therapy.  -- 2003
C5267	Falx_Meningioma	Anterior_Cranial_Fossa_Meningioma	Falx Meningioma|Cerebral Falx Meningioma|Falcine Meningioma|Falx Cerebri Meningioma|Meningioma of Cerebral Falx|Meningioma of Falx Cerebri|Meningioma of Falx of Cerebrum|Meningioma of the Cerebral Falx|Meningioma of the Falx Cerebri|Meningioma of the Falx of the Cerebrum
C5268	Cavernous_Sinus_Meningioma	Anterior_Cranial_Fossa_Meningioma|Skull_Base_Neoplasm	Cavernous Sinus Meningioma|Meningioma of Cavernous Sinus|Meningioma of the Cavernous Sinus
C5269	Intracerebral_Cystic_Meningioma	Cerebral_Meningioma	Intracerebral Cystic Meningioma
C5270	Cerebellar_Papillary_Meningioma	Cerebellar_Neoplasm|Intracranial_Meningioma|Papillary_Meningioma	Cerebellar Papillary Meningioma|Papillary Meningioma of Cerebellum|Papillary Meningioma of the Cerebellum
C5271	Petrous_Apex_Meningioma	Supratentorial_Meningioma	Petrous Apex Meningioma|Meningioma of Petrous Apex|Meningioma of Petrous Ridge|Meningioma of the Petrous Apex|Meningioma of the Petrous Ridge|Petrous Ridge Meningioma
C5272	Skull_Base_Meningioma	Intracranial_Meningioma|Skull_Base_Neoplasm	Skull Base Meningioma|Meningioma of Skull Base|Meningioma of the Skull Base
C5273	Intraventricular_Meningioma	Intracranial_Meningioma|Intraventricular_Brain_Neoplasm	Intraventricular Meningioma
C5274	Metastatic_Meningioma	Meningioma	Metastatic Meningioma
C5275	Multiple_Intraspinal_Meningiomas	Intraspinal_Meningioma|Meningiomatosis	Multiple Intraspinal Meningiomas|Multiple Meningiomas of Spinal Canal and Spinal Cord|Multiple Meningiomas of the Spinal Canal and Spinal Cord|Multiple Spinal Canal and Spinal Cord Meningiomas
C5276	Primary_Lung_Meningioma	Lung_Meningioma	Primary Lung Meningioma|Primary Meningioma of Lung|Primary Meningioma of the Lung|Primary Pulmonary Meningioma
C5277	Primary_Cutaneous_Meningioma	Dermal_Neoplasm|Ectopic_Meningioma	Primary Cutaneous Meningioma|Primary Meningioma of Skin|Primary Meningioma of the Skin|Primary Skin Meningioma
C5278	Petroclival_Meningioma	Skull_Base_Meningioma	Petroclival Meningioma
C5279	Multiple_Skull_Base_Meningioma	Meningiomatosis|Skull_Base_Meningioma	Multiple Skull Base Meningioma
C5280	Foramen_Magnum_Meningioma	Infratentorial_Neoplasm|Skull_Base_Meningioma	Foramen Magnum Meningioma|Meningioma of Foramen Magnum|Meningioma of the Foramen Magnum
C5281	Anterior_Foramen_Magnum_Meningioma	Foramen_Magnum_Meningioma	Anterior Foramen Magnum Meningioma|Meningioma of Anterior Foramen Magnum|Meningioma of the Anterior Foramen Magnum
C5282	Posterior_Foramen_Magnum_Meningioma	Foramen_Magnum_Meningioma	Posterior Foramen Magnum Meningioma|Meningioma of Posterior Foramen Magnum|Meningioma of the Posterior Foramen Magnum
C5283	Diaphragma_Sellae_Meningioma	Sella_Turcica_Neoplasm|Skull_Base_Meningioma	Diaphragma Sellae Meningioma|Diaphragm Sellae Meningioma|Meningioma of Diaphragm Sellae|Meningioma of Diaphragma Sellae|Meningioma of the Diaphragm Sellae|Meningioma of the Diaphragma Sellae
C5284	Tuberculum_Sellae_Meningioma	Anterior_Cranial_Fossa_Meningioma|Sella_Turcica_Neoplasm	Tuberculum Sellae Meningioma|Meningioma of Tuberculum Sellae|Meningioma of the Tuberculum Sellae
C5285	Sphenoorbital_Meningioma	Skull_Base_Meningioma	Sphenoorbital Meningioma
C5286	Anterior_Cranial_Fossa_Meningioma	Supratentorial_Meningioma|Supratentorial_Neoplasm	Anterior Cranial Fossa Meningioma|Anterior Fossa Meningioma|Meningioma of Anterior Cranial Fossa|Meningioma of Anterior Fossa|Meningioma of the Anterior Cranial Fossa|Meningioma of the Anterior Fossa
C5287	Spinal_Multifocal_Clear_Cell_Meningioma	Clear_Cell_Meningioma|Intraspinal_Meningioma	Spinal Multifocal Clear Cell Meningioma|Multifocal Clear Cell Meningioma of Spine|Multifocal Clear Cell Meningioma of the Spine	A clear cell meningioma arising in multiple areas of the spinal cord characterized by the presence of clear glycogen-rich polygonal cells.
C5288	Lower_Clivus_Meningioma	Clivus_Meningioma	Lower Clivus Meningioma|Meningioma of Lower Clivus|Meningioma of the Lower Clivus
C5289	Clivus_Meningioma	Posterior_Cranial_Fossa_Meningioma|Skull_Base_Meningioma	Clivus Meningioma|Meningioma of Clivus|Meningioma of the Clivus
C5290	Upper_Clivus_Meningioma	Clivus_Meningioma	Upper Clivus Meningioma|Meningioma of Upper Clivus|Meningioma of the Upper Clivus
C5291	Radiation-Induced_Intracranial_Meningioma	Intracranial_Meningioma|Radiation-Related_Neoplasm	Radiation-Induced Intracranial Meningioma
C5292	Frontal_Convexity_Meningioma	Cerebral_Convexity_Meningioma	Frontal Convexity Meningioma
C5293	Jugular_Foramen_Meningioma	Jugular_Foramen_Neoplasm|Meningioma_by_Site	Jugular Foramen Meningioma|Meningioma of Jugular Foramen|Meningioma of the Jugular Foramen
C5294	Deletions_of_the_Short_Arm_of_Chromosome_1_1p_Associated_Meningiomas	Meningioma	Deletion of the Short Arm of Chromosome 1 (1p) Associated Meningioma|Deletion of Short Arm of Chromosome 1 (1p) Associated Meningioma
C5295	Brain_Stem_Intraparenchymal_Clear_Cell_Meningioma	Brain_Stem_Neoplasm|Clear_Cell_Meningioma|Posterior_Cranial_Fossa_Meningioma	Brain Stem Intraparenchymal Clear Cell Meningioma|Brainstem Intraparenchymal Clear Cell Meningioma|Intraparenchymal Clear Cell Meningioma of Brainstem|Intraparenchymal Clear Cell Meningioma of the Brainstem	A morphologic variant of meningioma arising from the brain stem.  It is characterized by the presence of clear glycogen-rich polygonal cells.
C5296	Cervical_Intraspinal_Meningioma	Intraspinal_Meningioma	Cervical Intraspinal Meningioma|Cervical Spinal Canal and Spinal Cord Meningioma|Meningioma of Cervical Spinal Canal and Spinal Cord|Meningioma of the Cervical Spinal Canal and Spinal Cord
C5297	Thoracic_Intraspinal_Meningioma	Intraspinal_Meningioma	Thoracic Intraspinal Meningioma|Meningioma of Thoracic Spinal Canal and Spinal Cord|Meningioma of the Thoracic Spinal Canal and Spinal Cord|Thoracic Spinal Canal and Spinal Cord Meningioma
C5298	Lumbar_Intraspinal_Meningioma	Intraspinal_Meningioma	Lumbar Intraspinal Meningioma|Lumbar Spinal Canal and Spinal Cord Meningioma|Meningioma of Lumbar Spinal Canal and Spinal Cord|Meningioma of the Lumbar Spinal Canal and Spinal Cord
C5299	Sacral_Intraspinal_Meningioma	Intraspinal_Meningioma	Sacral Intraspinal Meningioma|Meningioma of Sacral Spinal Canal and Spinal Cord|Meningioma of the Sacral Spinal Canal and Spinal Cord|Sacral Spinal Canal and Spinal Cord Meningioma
C5300	Cerebellopontine_Angle_Meningioma	Cerebellopontine_Angle_Neoplasm|Posterior_Cranial_Fossa_Meningioma	Cerebellopontine Angle Meningioma|C-P Angle Meningioma|Cerebellar Pontine Angle Meningioma|Meningioma of C-P Angle|Meningioma of Cerebellar Pontine Angle|Meningioma of Cerebellopontine Angle|Meningioma of the C-P Angle|Meningioma of the Cerebellar Pontine Angle|Meningioma of the Cerebellopontine Angle
C5301	Hereditary_Meningioma	Meningioma	Hereditary Meningioma|Familial Meningioma
C5302	Lateral_Ventricle_Meningioma	Cerebral_Meningioma|Intraventricular_Meningioma	Lateral Ventricle Meningioma|Meningioma of Lateral Ventricle|Meningioma of the Lateral Ventricle
C5303	Parapharyngeal_Meningioma	Ectopic_Meningioma	Parapharyngeal Meningioma
C5304	Bilateral_Optic_Nerve_Meningioma	Visual_Pathway_Meningioma	Bilateral Optic Nerve Meningioma|Bilateral Meningioma of Optic Nerve|Bilateral Meningioma of the Optic Nerve
C5305	Deletions_of_Chromosome_22_Associated_Meningiomas	Meningioma	Deletion of Chromosome 22 Associated Meningioma
C5306	Deletions_of_Chromosome_3p_Associated_Meningiomas	Meningioma	Deletion of Chromosome 3p Associated Meningioma
C5307	Internal_Auditory_Canal_Meningioma	Middle_Cranial_Fossa_Meningioma|Skull_Base_Meningioma	Internal Auditory Canal Meningioma|Meningioma of Internal Auditory Canal|Meningioma of the Internal Auditory Canal
C5308	Ectopic_Meningioma	Meningothelial_Cell_Neoplasm	Ectopic Meningioma|Primary Ectopic Meningioma
C5309	Ethmoid_Sinus_Primary_Ectopic_Meningioma	Ectopic_Meningioma|Ethmoid_Sinus_Neoplasm	Ethmoid Sinus Primary Ectopic Meningioma|Ethmoidal Sinus Primary Ectopic Meningioma|Primary Ectopic Meningioma of Ethmoid Sinus|Primary Ectopic Meningioma of Ethmoidal Sinus|Primary Ectopic Meningioma of the Ethmoid Sinus|Primary Ectopic Meningioma of the Ethmoidal Sinus
C5310	Epidural_Spinal_Canal_Meningioma	Epidural_Spinal_Canal_Neoplasm|Intraspinal_Meningioma	Epidural Spinal Canal Meningioma|Meningioma of Epidural Spinal Canal|Meningioma of the Epidural Spinal Canal
C5311	Pituitary_Stalk_Meningioma	Anterior_Cranial_Fossa_Meningioma|Sella_Turcica_Neoplasm	Pituitary Stalk Meningioma|Meningioma of Pituitary Stalk|Meningioma of the Pituitary Stalk
C5312	Recurrent_Meningioma	Meningioma	Recurrent Meningioma|Relapsed Meningioma
C5313	Sphenocavernous_Meningioma	Skull_Base_Meningioma	Sphenocavernous Meningioma
C5314	Primary_Low-Grade_B-Cell_Dural_Lymphoma	Low-Grade_B-Cell_Non-Hodgkin_s_Lymphoma	Primary Low Grade B-Cell Dural Lymphoma|Primary Low-Grade B-Cell Lymphoma of Dura|Primary Low-Grade B-Cell Lymphoma of the Dura
C5315	Breast_Cyst	Cyst|Reproductive_System_Finding	Breast Cyst|Cyst of Breast|Cyst of the Breast
C5316	Borderline_Breast_Phyllodes_Tumor	Borderline_Phyllodes_Tumor|Phyllodes_Tumor_of_the_Breast	Borderline Breast Phyllodes Tumor|Borderline Breast Phyllodes Neoplasm|Borderline Phyllodes Neoplasm of Breast|Borderline Phyllodes Neoplasm of the Breast|Borderline Phyllodes Tumor of Breast|Borderline Phyllodes Tumor of the Breast
C5317	Leptomeningeal_Melanoma	Central_Nervous_System_Melanoma|Malignant_Leptomeningeal_Neoplasm	Leptomeningeal Melanoma|Melanoma of Leptomeninges|Melanoma of the Leptomeninges|Meningeal Melanoma
C5318	Childhood_Leptomeningeal_Melanoma	Leptomeningeal_Melanoma|Malignant_Childhood_Central_Nervous_System_Neoplasm	Childhood Leptomeningeal Melanoma|Pediatric Leptomeningeal Melanoma
C5319	Adult_Leptomeningeal_Melanoma	Adult_Central_Nervous_System_Neoplasm|Leptomeningeal_Melanoma	Adult Leptomeningeal Melanoma|Melanoma of Adult Leptomeninges|Melanoma of the Adult Leptomeninges
C5320	Peripheral_Intraneural_Angiosarcoma	Angiosarcoma	Peripheral Intraneural Angiosarcoma|Peripheral Intraneural Hemangiosarcoma
C5321	Macrocystic_Schwannoma	Schwannoma	Macrocystic Schwannoma|Macrocystic Neurilemmoma
C5322	Primary_Central_Nervous_System_Anaplastic_Large_Cell_Lymphoma	Anaplastic_Large_Cell_Lymphoma|Central_Nervous_System_T-Cell_Non-Hodgkin_s_Lymphoma	Primary Central Nervous System Anaplastic Large Cell Lymphoma|Anaplastic CNS Large Cell Lymphoma|Anaplastic Central Nervous System Large Cell Lymphoma|Anaplastic Large Cell Lymphoma of CNS|Anaplastic Large Cell Lymphoma of Central Nervous System|Anaplastic Large Cell Lymphoma of the CNS|Anaplastic Large Cell Lymphoma of the Central Nervous System|Primary CNS Anaplastic Large Cell Lymphoma
C5323	Jugular_Foramen_Schwannoma	Jugular_Foramen_Neoplasm|Peripheral_Nerve_Schwannoma	Jugular Foramen Schwannoma|Jugular Foramen Neurilemmoma|Neurilemmoma of Jugular Foramen|Neurilemmoma of the Jugular Foramen|Schwannoma of Jugular Foramen|Schwannoma of the Jugular Foramen
C5324	Cauda_Equina_Paraganglioma	Cauda_Equina_Neoplasm|Extra-Adrenal_Paraganglioma	Cauda Equina Paraganglioma|Paraganglioma of Cauda Equina|Paraganglioma of Filum Terminale|Paraganglioma of the Cauda Equina|Paraganglioma of the Filum Terminale	An extra-adrenal spinal paraganglioma arising from the cauda equina.  It should not be confused with glomus coccygeum, a structure unrelated to paraganglia.  Clinically, it may be asymptomatic or present with cauda equina syndrome, lower back pain, or leg pain.
C5325	Intestinal_Paraganglioma	Intestinal_Neuroendocrine_Neoplasm|Intra-Abdominal_Paraganglioma	Intestinal Gangliocytic Paraganglioma|Gangliocytic Intestinal Paraganglioma|Gangliocytic Paraganglioma of Intestine|Gangliocytic Paraganglioma of the Intestine	A usually indolent, extra-adrenal paraganglioma affecting the intestine.  Patients may present with gastrointestinal hemorrhage.  Unlike the conventional paragangliomas, this tumor has a peculiar morphologic appearance; it consists of a mixture of epithelioid neuroendocrine cells, Schwann-like cells, and ganglion cell-like elements.
C5326	Intra-Abdominal_Paraganglioma	Extra-Adrenal_Paraganglioma	Intra-Abdominal Paraganglioma|Paraganglioma of Intra-Abdominal Area|Paraganglioma of the Intra-Abdominal Area	A benign or malignant extra-adrenal paraganglioma arising from the abdominal cavity.
C5327	Head_and_Neck_Paraganglioma	Extra-Adrenal_Paraganglioma|Head_and_Neck_Neoplasm	Head and Neck Paraganglioma|Paraganglioma of Head and Neck|Paraganglioma of the Head and Neck	A benign or malignant extra-adrenal paraganglioma arising from paraganglia in the head and neck.  Representative examples include the carotid body and jugulotympanic paragangliomas.
C5328	Extra-Adrenal_Retroperitoneal_Paragangliomas	Extra-Adrenal_Sympathetic_Paraganglioma|Retroperitoneal_Neoplasm	Extra-Adrenal Retroperitoneal Paraganglioma|Paraganglioma of Extra-Adrenal Retroperitoneal Area|Paraganglioma of the Extra-Adrenal Retroperitoneal Area	A benign or malignant sympathetic paraganglioma arising from the retroperitoneum, outside the adrenal gland.
C5329	Hereditary_Paraganglioma	Extra-Adrenal_Paraganglioma	Hereditary Paraganglioma|Familial Paraganglioma	An inherited neoplasm arising from paraganglia.  The majority of cases (up to 80%) are multifocal.
C5330	Distraction	Mental_and_Behavioral_Signs_and_Symptoms	Distraction|distraction	In medicine, a pain relief method that takes the patient's attention away from the pain.
C5332	Treatment-Induced_Anemia	Anemia	Treatment-Induced Anemia
C5334	Esophageal_Leiomyosarcoma	Esophageal_Sarcoma|Leiomyosarcoma	Esophageal Leiomyosarcoma|Esophagus Leiomyosarcoma|Leiomyosarcoma of Esophagus|Leiomyosarcoma of the Esophagus
C5335	Small_Intestinal_Sarcoma	Malignant_Small_Intestinal_Neoplasm|Soft_Tissue_Sarcoma	Small Intestinal Sarcoma|Sarcoma of Small Bowel|Sarcoma of Small Intestine|Sarcoma of the Small Bowel|Sarcoma of the Small Intestine|Sarcoma, Small Intestinal|Small Bowel Sarcoma|Small Intestine Sarcoma
C5336	Small_Intestinal_Fibrosarcoma	Small_Intestinal_Sarcoma|Soft_Tissue_Fibrosarcoma	Small Intestinal Fibrosarcoma|Fibrosarcoma of Small Bowel|Fibrosarcoma of Small Intestine|Fibrosarcoma of the Small Bowel|Fibrosarcoma of the Small Intestine|Fibrosarcoma, Small Intestine|Small Bowel Fibrosarcoma|Small Intestine Fibrosarcoma
C5337	Small_Intestinal_Hodgkin_s_Lymphoma	Gastrointestinal_Hodgkin_s_Lymphoma|Small_Intestinal_Lymphoma	Small Intestinal Hodgkin's Lymphoma|Hodgkin's Disease of Small Bowel|Hodgkin's Disease of Small Intestine|Hodgkin's Disease of the Small Bowel|Hodgkin's Disease of the Small Intestine|Hodgkin's Lymphoma of Small Bowel|Hodgkin's Lymphoma of Small Intestine|Hodgkin's Lymphoma of the Small Bowel|Hodgkin's Lymphoma of the Small Intestine|Primary Small Intestinal Hodgkin's Lymphoma|Small Bowel Hodgkin's Disease|Small Bowel Hodgkin's Lymphoma|Small Intestine Hodgkin Lymphoma|Small Intestine Hodgkin's Disease|Small Intestine Hodgkin's Lymphoma
C5338	Duodenal_Villous_Adenoma	Duodenal_Adenoma|Small_Intestinal_Villous_Adenoma	Duodenal Villous Adenoma|Villous Adenoma of Duodenum|Villous Adenoma of the Duodenum|Villous Adenoma, Duodenum
C5339	Small_Intestinal_Lipoma	Benign_Small_Intestinal_Neoplasm|Lipoma	Small Intestinal Lipoma|Lipoma of Small Bowel|Lipoma of Small Intestine|Lipoma of the Small Bowel|Lipoma of the Small Intestine|Small Bowel Lipoma
C5340	Small_Intestinal_Adenoma	Adenomatous_Polyp|Gastrointestinal_Adenoma|Small_Intestinal_Neoplasm|Small_Intestinal_Polyp	Small Intestinal Adenoma|Adenoma of Small Bowel|Adenoma of Small Intestine|Adenoma of the Small Bowel|Adenoma of the Small Intestine|Small Bowel Adenoma
C5341	Esophageal_Sarcoma	Malignant_Esophageal_Neoplasm|Soft_Tissue_Sarcoma	Esophageal Sarcoma|Esophagus Sarcoma|Sarcoma of Esophagus|Sarcoma of the Esophagus|Sarcoma, Esophagus
C5342	Esophageal_Adenoid_Cystic_Carcinoma	Adenoid_Cystic_Carcinoma|Esophageal_Carcinoma	Esophageal Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Esophagus|Adenoid Cystic Carcinoma of the Esophagus|Adenoid Cystic Carcinoma, Esophagus|Adenoid Cystic Esophagus Carcinoma|Esophagus Adenoid Cystic Carcinoma	An infrequent esophageal carcinoma arising from esophageal glands.  (WHO, 2000) -- 2003
C5343	Esophageal_Mucoepidermoid_Carcinoma	Esophageal_Carcinoma|Mucoepidermoid_Carcinoma	Esophageal Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Esophagus|Mucoepidermoid Carcinoma of the Esophagus|Mucoepidermoid Esophageal Carcinoma|Mucoepidermoid Esophagus Carcinoma	A rare carcinoma of the esophagus which contains squamous cells, mucus secreting cells, and cells of an intermediate type.  (WHO, 2000) -- 2003
C5344	Esophageal_Squamous_Cell_Papilloma	Benign_Esophageal_Neoplasm|Squamous_Cell_Papilloma	Esophageal Squamous Papilloma|Esophagus Squamous Cell Papilloma|Squamous Cell Papilloma of Esophagus|Squamous Cell Papilloma of the Esophagus	A rare benign tumor located in the distal third of the esophagus.  Histologically, cores of fibrovascular tissue are covered by mature stratified squamous epithelium.  Malignant progression to squamous cell carcinoma is extremely rare. (WHO, 2000) -- 2003
C5345	Telangiectatic_Glomangioma	Cutaneous_Glomangioma	Telangiectatic Glomangioma
C5346	Endocardial_Neoplasm	Cardiac_Neoplasm	Endocardial Neoplasm|Endocardial Tumor|Neoplasm of Endocardium|Neoplasm of the Endocardium|Tumor of Endocardium|Tumor of the Endocardium
C5347	Epicardial_Neoplasm	Cardiac_Neoplasm	Epicardial Neoplasm|Epicardial Tumor|Neoplasm of Epicardium|Neoplasm of the Epicardium|Tumor of Epicardium|Tumor of the Epicardium
C5348	Great_Vessel_Neoplasm	Cardiovascular_Neoplasm	Great Vessel Neoplasm|Great Vessel Tumor|Neoplasm of Great Vessel|Tumor of Great Vessel
C5349	Myocardial_Neoplasm	Cardiac_Neoplasm	Myocardial Neoplasm|Myocardial Tumor|Neoplasm of Myocardium|Neoplasm of the Myocardium|Tumor of Myocardium|Tumor of the Myocardium
C5350	Hereditary_Glomangioma	Glomangioma	Hereditary Glomangioma|Familial Glomangioma
C5351	Metastatic_Jugulotympanic_Paraganglioma	Malignant_Jugulotympanic_Paraganglioma	Metastatic Jugulotympanic Paraganglioma|Metastatic Glomus Jugulare Neoplasm|Metastatic Glomus Jugulare Tumor|Metastatic Neoplasm of Glomus Jugulare|Metastatic Neoplasm of the Glomus Jugulare|Metastatic Tumor of Glomus Jugulare|Metastatic Tumor of the Glomus Jugulare	A jugulotympanic paraganglioma that has metastasized to other anatomic sites.
C5352	Benign_Orbit_Hemangiopericytoma	Benign_Hemangiopericytoma|Benign_Orbit_Neoplasm|Orbit_Hemangiopericytoma	Benign Orbit Hemangiopericytoma|Benign Hemangiopericytoma of Orbit|Benign Hemangiopericytoma of the Orbit
C5353	Breast_Hemangioma	Benign_Breast_Neoplasm|Hemangioma|Vascular_Breast_Neoplasm	Breast Hemangioma|Angioma of Breast|Angioma of the Breast|Breast Angioma|Hemangioma of Breast|Hemangioma of the Breast	Hemangioma is a very common benign tumor.  However, vascular tumors of the breast are rare.  Hemangioma's most frequently occur in the pediatric population.  This tumor is composed of newly formed blood vessels.  Types of hemangiomas include: capillary and cavernous.  This specific concept refers to this tumor occuring in the breast. - 2002
C5354	Cutaneous_Vascular_Neoplasm	Dermal_Neoplasm|Skin_Vascular_Disorder|Vascular_Neoplasm	Cutaneous Vascular Neoplasm|Blood Vessel Tumor of Skin|Blood Vessel Tumor of the Skin|Cutaneous Vascular Tumor|Skin Vascular Neoplasm|Skin Vascular Tumor|Vascular Neoplasm of Skin|Vascular Neoplasm of the Skin|Vascular Skin Neoplasm|Vascular Skin Tumor|Vascular Tumor of Skin|Vascular Tumor of the Skin
C5355	Intravascular_Angiomyoma	Angiomyoma	Intravascular Angiomyoma|Intravascular Angioleiomyoma
C5356	Intravascular_Leiomyomatosis_of_the_Uterus	Intravenous_Leiomyomatosis|Uterine_Corpus_Leiomyomatosis	Uterine Corpus Intravenous Leiomyomatosis|Intravascular Leiomyomatosis of Uterus|Intravascular Leiomyomatosis of the Uterus
C5357	Benign_Cardiac_Germ_Cell_Neoplasm	Benign_Cardiac_Neoplasm	Benign Cardiac Germ Cell Neoplasm|Benign Cardiac Germ Cell Tumor|Benign Germ Cell Neoplasm of Heart|Benign Germ Cell Neoplasm of the Heart|Benign Germ Cell Tumor of Heart|Benign Germ Cell Tumor of the Heart|Benign Heart Germ Cell Neoplasm|Benign Heart Germ Cell Tumor
C5358	Benign_Cardiac_Schwannoma	Benign_Cardiac_Neoplasm|Benign_Schwannoma|Peripheral_Nerve_Schwannoma	Benign Cardiac Schwannoma|Benign Cardiac Neurilemmoma|Benign Heart Neurilemmoma|Benign Neurilemoma of Heart|Benign Neurilemoma of the Heart
C5359	Cardiac_Neurofibroma	Benign_Cardiac_Neoplasm|Neurofibroma	Cardiac Neurofibroma|Heart Neurofibroma|Neurofibroma of Heart|Neurofibroma of the Heart
C5360	Cardiac_Granular_Cell_Tumor	Epicardial_Neoplasm|Granular_Cell_Tumor	Cardiac Granular Cell Tumor|Cardiac Granular Cell Neoplasm|Granular Cell Neoplasm of Heart|Granular Cell Neoplasm of the Heart|Granular Cell Tumor of Heart|Granular Cell Tumor of the Heart
C5361	Cardiac_Fibrosarcoma	Cardiac_Sarcoma|Soft_Tissue_Fibrosarcoma	Cardiac Fibrosarcoma|Fibrosarcoma of Heart|Fibrosarcoma of the Heart|Heart Fibrosarcoma
C5362	Cardiac_Hemangioendothelioma	Epithelioid_Hemangioendothelioma|Malignant_Cardiac_Neoplasm	Cardiac Epithelioid Hemangioendothelioma|Cardiac Epithelioid Angioendothelioma|Epithelioid Angioendothelioma of Heart|Epithelioid Angioendothelioma of the Heart|Epithelioid Hemangioendothelioma of Heart|Epithelioid Hemangioendothelioma of the Heart|Heart Epithelioid Angioendothelioma|Heart Epithelioid Hemangioendothelioma
C5363	Cardiac_Kaposi_s_Sarcoma	Cardiac_Sarcoma|Kaposi_s_Sarcoma	Cardiac Kaposi's Sarcoma|Heart Kaposi's Sarcoma|Kaposi's Sarcoma of Heart|Kaposi's Sarcoma of the Heart
C5364	Cardiac_Leiomyosarcoma	Cardiac_Sarcoma|Leiomyosarcoma	Cardiac Leiomyosarcoma|Heart Leiomyosarcoma|Leiomyosarcoma of Heart|Leiomyosarcoma of the Heart
C5365	Malignant_Cardiac_Hemangiopericytoma	Malignant_Cardiac_Neoplasm|Malignant_Hemangiopericytoma	Malignant Cardiac Hemangiopericytoma|Malignant Heart Hemangiopericytoma|Malignant Hemangiopericytoma of Heart|Malignant Hemangiopericytoma of the Heart
C5367	Malignant_Cardiac_Peripheral_Nerve_Sheath_Tumor	Malignant_Cardiac_Neoplasm|Malignant_Peripheral_Nerve_Sheath_Tumor	Malignant Cardiac Peripheral Nerve Sheath Tumor|Cardiac MPNST|Heart MPNST|MPNST of Heart|MPNST of the Heart|Malignant Cardiac Neurilemmoma|Malignant Cardiac Peripheral Nerve Sheath Neoplasm|Malignant Cardiac Schwannoma|Malignant Heart Neurilemmoma|Malignant Heart Peripheral Nerve Sheath Neoplasm|Malignant Heart Peripheral Nerve Sheath Tumor|Malignant Heart Schwannoma|Malignant Neurilemmoma of Heart|Malignant Neurilemmoma of the Heart|Malignant Peripheral Nerve Sheath Neoplasm of Heart|Malignant Peripheral Nerve Sheath Neoplasm of the Heart|Malignant Peripheral Nerve Sheath Tumor of Heart|Malignant Peripheral Nerve Sheath Tumor of the Heart|Malignant Schwannoma of Heart|Malignant Schwannoma of the Heart
C5368	Cardiac_Lymphoma	Lymphoma_by_Site|Malignant_Cardiac_Neoplasm	Cardiac Lymphoma|Heart Lymphoma|Lymphoma of Heart|Lymphoma of the Heart|Primary Cardiac Lymphoma
C5369	Secondary_Lymphoma_of_Heart	Lymphoma|Metastatic_Neoplasm_to_the_Heart	Metastatic Lymphoma to the Heart|Secondary Cardiac Lymphoma|Secondary Heart Lymphoma
C5370	Heart_Myeloid_Sarcoma	Malignant_Cardiac_Neoplasm|Myeloid_Sarcoma	Cardiac Myeloid Sarcoma|Cardiac Extramedullary Myeloid Neoplasm|Cardiac Extramedullary Myeloid Tumor|Extramedullary Myeloid Neoplasm of Heart|Extramedullary Myeloid Neoplasm of the Heart|Extramedullary Myeloid Tumor of Heart|Extramedullary Myeloid Tumor of the Heart|Heart Extramedullary Myeloid Neoplasm|Heart Extramedullary Myeloid Tumor
C5371	Malignant_Cardiac_Germ_Cell_Neoplasm	Malignant_Cardiac_Neoplasm	Malignant Cardiac Germ Cell Neoplasm|Malignant Cardiac Germ Cell Tumor|Malignant Germ Cell Neoplasm of Heart|Malignant Germ Cell Neoplasm of the Heart|Malignant Germ Cell Tumor of Heart|Malignant Germ Cell Tumor of the Heart|Malignant Heart Germ Cell Neoplasm|Malignant Heart Germ Cell Tumor
C5372	Inferior_Vena_Cava_Leiomyosarcoma	Vascular_Leiomyosarcoma	Inferior Vena Cava Leiomyosarcoma|Leiomyosarcoma of Inferior Vena Cava|Leiomyosarcoma of the Inferior Vena Cava	A leiomyosarcoma predominantly affecting females, often presenting with ascites and leg edema. -- 2003
C5373	Pulmonary_Artery_Leiomyosarcoma	Vascular_Leiomyosarcoma	Pulmonary Artery Leiomyosarcoma|Leiomyosarcoma of Pulmonary Artery|Leiomyosarcoma of the Pulmonary Artery
C5374	Pulmonary_Vein_Leiomyosarcoma	Vascular_Leiomyosarcoma	Pulmonary Vein Leiomyosarcoma|Leiomyosarcoma of Pulmonary Vein|Leiomyosarcoma of the Pulmonary Vein
C5375	Malignant_Aortic_Neoplasm	Malignant_Great_Vessel_Neoplasm	Malignant Aortic Neoplasm|Aortic Malignant Neoplasm|Aortic Malignant Tumor|Malignant Neoplasm of Aorta|Malignant Neoplasm of the Aorta|Malignant Tumor of Aorta|Malignant Tumor of the Aorta
C5376	Aortic_Angiosarcoma	Angiosarcoma	Aortic Angiosarcoma|Angiosarcoma of Aorta|Angiosarcoma of the Aorta|Aortic Hemangiosarcoma|Hemangiosarcoma of Aorta|Hemangiosarcoma of the Aorta
C5377	Malignant_Inferior_Vena_Cava_Neoplasm	Malignant_Great_Vessel_Neoplasm	Malignant Inferior Vena Cava Neoplasm|Malignant Neoplasm of Inferior Vena Cava|Malignant Neoplasm of the Inferior Vena Cava|Malignant Tumor of Inferior Vena Cava|Malignant Tumor of the Inferior Vena Cava
C5378	Superior_Vena_Cava_Angiosarcoma	Angiosarcoma	Superior Vena Cava Angiosarcoma|Angiosarcoma of Superior Vena Cava|Angiosarcoma of the Superior Vena Cava
C5379	Malignant_Superior_Vena_Cava_Neoplasm	Malignant_Great_Vessel_Neoplasm	Malignant Superior Vena Cava Neoplasm|Malignant Neoplasm of Superior Vena Cava|Malignant Neoplasm of the Superior Vena Cava|Malignant Tumor of Superior Vena Cava|Malignant Tumor of the Superior Vena Cava
C5380	Malignant_Pulmonary_Artery_Neoplasm	Malignant_Great_Vessel_Neoplasm	Malignant Pulmonary Artery Neoplasm|Malignant Neoplasm of Pulmonary Artery|Malignant Neoplasm of the Pulmonary Artery|Malignant Tumor of Pulmonary Artery|Malignant Tumor of the Pulmonary Artery
C5381	Pulmonary_Artery_Choriocarcinoma	Choriocarcinoma|Malignant_Pulmonary_Artery_Neoplasm	Pulmonary Artery Choriocarcinoma|Choriocarcinoma of Pulmonary Artery|Choriocarcinoma of the Pulmonary Artery|Chorioepithelioma of Pulmonary Artery|Chorioepithelioma of the Pulmonary Artery|Pulmonary Artery Chorioepithelioma|Pulmonary Artery Syncytioma|Syncytioma of Pulmonary Artery|Syncytioma of the Pulmonary Artery
C5383	Malignant_Pulmonary_Vein_Neoplasm	Malignant_Great_Vessel_Neoplasm	Malignant Pulmonary Vein Neoplasm|Malignant Neoplasm of Pulmonary Vein|Malignant Neoplasm of the Pulmonary Vein|Malignant Tumor of Pulmonary Vein|Malignant Tumor of the Pulmonary Vein
C5384	Recurrent_Angiosarcoma	Angiosarcoma	Recurrent Angiosarcoma|Recurrent Hemangiosarcoma|Relapsed Angiosarcoma|Relapsed Hemangiosarcoma	The reemergence of angiosarcoma after a period of remission
C5385	Uterine_Angiosarcoma	Angiosarcoma|Malignant_Uterine_Neoplasm	Uterine Angiosarcoma|Angiosarcoma of Uterus|Angiosarcoma of the Uterus|Hemangiosarcoma of Uterus|Hemangiosarcoma of the Uterus|Uterine Hemangiosarcoma
C5386	Retroperitoneal_Hemangiopericytoma	Hemangiopericytoma	Retroperitoneal Hemangiopericytoma
C5387	Vascular_Leiomyosarcoma	Leiomyosarcoma	Vascular Leiomyosarcoma|Leiomyosarcoma of Vessels|Leiomyosarcoma of the Vessels
C5388	Renal_Vein_Leiomyosarcoma	Vascular_Leiomyosarcoma	Renal Vein Leiomyosarcoma|Leiomyosarcoma of Renal Vein|Leiomyosarcoma of the Renal Vein
C5389	Benign_Atrial_Neoplasm	Benign_Cardiac_Neoplasm	Benign Atrial Neoplasm|Benign Atrial Tumor|Benign Neoplasm of Atrium of Heart|Benign Neoplasm of Cardiac Atrium|Benign Neoplasm of the Atrium of the Heart|Benign Neoplasm of the Cardiac Atrium|Benign Tumor of Atrium of Heart|Benign Tumor of Cardiac Atrium|Benign Tumor of the Atrium of the Heart|Benign Tumor of the Cardiac Atrium
C5390	Atrial_Paraganglioma	Cardiac_Paraganglioma	Atrial Paraganglioma|Paraganglioma of Atrium|Paraganglioma of Atrium of Heart|Paraganglioma of Cardiac Atrium|Paraganglioma of the Atrium|Paraganglioma of the Atrium of the Heart|Paraganglioma of the Cardiac Atrium	A benign or malignant extra-adrenal paraganglioma arising from paraganglia located in the cardiac atrium.
C5392	Malignant_Cardiac_Paraganglioma	Cardiac_Paraganglioma|Malignant_Cardiac_Neoplasm|Malignant_Extra-Adrenal_Paraganglioma	Malignant Cardiac Paraganglioma|Malignant Heart Paraganglioma|Malignant Paraganglioma of Heart|Malignant Paraganglioma of the Heart	A paraganglioma of the heart that metastasizes to regional or distant anatomic sites.
C5393	Parotid_Gland_Lymphangioma	Benign_Parotid_Gland_Neoplasm|Lymphangioma	Parotid Gland Lymphangioma|Lymphangioma of Parotid|Lymphangioma of Parotid Gland|Lymphangioma of the Parotid|Lymphangioma of the Parotid Gland|Parotid Lymphangioma
C5394	Solitary_Adult_Fibroma	Dermal_Fibroma	Solitary Adult Fibroma|Solitary Adult Cutaneous Fibroma|Solitary Adult Skin Fibroma
C5395	Colon_Cavernous_Hemangioma	Benign_Colon_Neoplasm|Cavernous_Hemangioma	Colon Cavernous Hemangioma|Cavernous Angioma of Colon|Cavernous Angioma of the Colon|Cavernous Hemangioma of Colon|Cavernous Hemangioma of the Colon|Colon Cavernous Angioma|Colonic Cavernous Angioma|Colonic Cavernous Hemangioma
C5396	Bone_Epithelioid_Hemangioma	Bone_Hemangioma|Epithelioid_Hemangioma	Bone Epithelioid Hemangioma|Bone Epithelioid Angioma|Epithelioid Angioma of Bone|Epithelioid Angioma of the Bone|Epithelioid Hemangioma of Bone|Epithelioid Hemangioma of the Bone|Osseous Epithelioid Angioma|Osseous Epithelioid Hemangioma
C5397	Parotid_Gland_Hemangioma	Benign_Parotid_Gland_Neoplasm|Hemangioma	Parotid Gland Hemangioma|Angioma of Parotid|Angioma of Parotid Gland|Angioma of the Parotid|Angioma of the Parotid Gland|Hemangioma of Parotid|Hemangioma of Parotid Gland|Hemangioma of the Parotid|Hemangioma of the Parotid Gland|Parotid Angioma|Parotid Gland Angioma|Parotid Hemangioma
C5398	Central_Nervous_System_Primitive_Neuroectodermal_Tumor	Embryonal_Neoplasm_of_the_CNS|Neuroectodermal_Tumor	Central Nervous System Primitive Neuroectodermal Tumor|CNS PNET|CNS Primitive Neuroectodermal Neoplasm|CNS Primitive Neuroectodermal Tumor|Central Nervous System PNET|Central Nervous System Primitive Neuroectodermal Neoplasm|Central Primitive Neuroectodermal Neoplasm|Central Primitive Neuroectodermal Tumor
C5399	Medulloblastoma_with_Leptomeningeal_Spread	Medulloblastoma|Metastasis_to_the_Leptomeninges	Medulloblastoma with Leptomeningeal Spread
C5400	Primitive_Neuroectodermal_Tumor_with_Leptomeningeal_Spread	Central_Nervous_System_Primitive_Neuroectodermal_Tumor|Metastasis_to_the_Leptomeninges	Primitive Neuroectodermal Tumor with Leptomeningeal Spread
C5401	Cerebellar_Vermis_Medulloblastoma	Medulloblastoma	Cerebellar Vermis Medulloblastoma|Medulloblastoma of Cerebellar Vermis|Medulloblastoma of the Cerebellar Vermis|Vermis Medulloblastoma
C5402	Region_17p13_Allelic_Loss_Associated_Medulloblastomas	Medulloblastoma	Region 17p13 Allelic Loss Associated Medulloblastoma
C5403	Malignant_Intracranial_Germ_Cell_Neoplasm	Central_Nervous_System_Germ_Cell_Neoplasm|Malignant_Extragonadal_Germ_Cell_Tumor|Malignant_Intracranial_Neoplasms_By_Morphology	Malignant Intracranial Germ Cell Tumor|Malignant Intracranial Germ Cell Neoplasm
C5405	Nevoid_Basal_Cell_Carcinoma_Syndrome_Associated_Medulloblastoma	Medulloblastoma	Nevoid Basal Cell Carcinoma Syndrome Associated Medulloblastoma
C5406	Spinal_Cord_Primitive_Neuroectodermal_Neoplasm	Central_Nervous_System_Primitive_Neuroectodermal_Tumor|Malignant_Spinal_Cord_Neoplasm	Spinal Cord Primitive Neuroectodermal Neoplasm|Primitive Neuroectodermal Neoplasm of Spinal Cord|Primitive Neuroectodermal Neoplasm of the Spinal Cord|Primitive Neuroectodermal Tumor of Spinal Cord|Primitive Neuroectodermal Tumor of the Spinal Cord|Spinal Cord PNET|Spinal Cord Primitive Neuroectodermal Tumor
C5407	Nodular_Medulloblastoma	Medulloblastoma	Nodular Medulloblastoma
C5408	Intradural_Extramedullary_Cauda_Equina_Astrocytoma	Astrocytic_Tumor|Cauda_Equina_Neoplasm	Intradural Extramedullary Cauda Equina Astrocytoma|Intradural Extramedullary Astrocytic Neoplasm of Cauda Equina|Intradural Extramedullary Astrocytic Neoplasm of the Cauda Equina|Intradural Extramedullary Astrocytic Tumor of Cauda Equina|Intradural Extramedullary Astrocytic Tumor of the Cauda Equina|Intradural Extramedullary Astrocytoma of Cauda Equina|Intradural Extramedullary Astrocytoma of the Cauda Equina|Intradural Extramedullary Cauda Equina Astrocytic Neoplasm|Intradural Extramedullary Cauda Equina Astrocytic Tumor
C5409	Central_Nervous_System_T-Cell_Non-Hodgkin_s_Lymphoma	Central_Nervous_System_Lymphoma|T-Cell_Non-Hodgkin_s_Lymphoma	Central Nervous System T-Cell Non-Hodgkin's Lymphoma|CNS T-Cell Lymphoma|Central Nervous System T-Cell Lymphoma|Central Nervous System T-Cell and NK-Cell Non-Hodgkin's Lymphoma|Primary Central Nervous System T-Cell Non-Hodgkin's Lymphoma|T-Cell Lymphoma of CNS|T-Cell Lymphoma of Central Nervous System|T-Cell Lymphoma of the CNS|T-Cell Lymphoma of the Central Nervous System
C5410	Primary_Intraocular_Lymphoma	Retired_Concepts	Primary Intraocular Lymphoma
C5411	Adult_Central_Nervous_System_Primitive_Neuroectodermal_Tumor	Central_Nervous_System_Primitive_Neuroectodermal_Tumor	Adult Central Nervous System Primitive Neuroectodermal Tumor|Adult CNS PNET|Adult CNS Primitive Neuroectodermal Neoplasm|Adult CNS Primitive Neuroectodermal Tumor|Adult Central Nervous System Primitive Neuroectodermal Neoplasm|Adult Central Primitive Neuroectodermal Neoplasm|Adult Central Primitive Neuroectodermal Tumour
C5412	Clival_Chordoma	Skull_Base_Chordoma	Clival Chordoma|Chordoma of Clivus|Chordoma of the Clivus
C5413	Cerebellopontine_Angle_Schwannoma	Cerebellopontine_Angle_Neoplasm|Schwannoma	Cerebellopontine Angle Schwannoma|C-P Angle Neurinoma|Cerebellar Pontine Angle Neurinoma|Cerebellopontine Angle Neurinoma
C5414	Cerebellopontine_Angle_Neoplasm	Infratentorial_Neoplasm	Cerebellopontine Angle Neoplasm|C-P Angle Neoplasm|C-P Angle Tumor|Cerebellar Pontine Angle Neoplasm|Cerebellar Pontine Angle Tumor|Cerebellopontine Angle Tumor|Neoplasm of C-P Angle|Neoplasm of Cerebellar Pontine Angle|Neoplasm of Cerebellopontine Angle|Neoplasm of the C-P Angle|Neoplasm of the Cerebellar Pontine Angle|Neoplasm of the Cerebellopontine Angle|Tumor of C-P Angle|Tumor of Cerebellar Pontine Angle|Tumor of Cerebellopontine Angle|Tumor of the C-P Angle|Tumor of the Cerebellar Pontine Angle|Tumor of the Cerebellopontine Angle
C5415	Multiple_Spinal_Meningeal_Cysts	Spinal_Meningeal_Cyst	Multiple Spinal Meningeal Cysts|Multiple Cysts of Spinal Meninges|Multiple Cysts of the Spinal Meninges|Multiple Spinal Meninges Cysts
C5416	Anaplastic_Secondary_Supratentorial_Astrocytoma	Anaplastic_Astrocytoma|Malignant_Supratentorial_Neoplasm	Anaplastic Secondary Supratentorial Astrocytoma|Anaplastic Secondary Supratentorial Astrocytic Neoplasm|Anaplastic Secondary Supratentorial Astrocytic Tumor|Grade III Secondary Supratentorial Astrocytic Neoplasm|Grade III Secondary Supratentorial Astrocytic Tumor|Grade III Secondary Supratentorial Astrocytoma|Undifferentiated Secondary Supratentorial Astrocytic Neoplasm|Undifferentiated Secondary Supratentorial Astrocytic Tumor|Undifferentiated Secondary Supratentorial Astrocytoma
C5417	Pineal_Gland_Epidermoid_Cyst	Central_Nervous_System_Epidermoid_Cyst|Pineal_Gland_Cyst	Pineal Gland Epidermoid Cyst|Epidermoid Cyst of Pineal Gland|Epidermoid Cyst of the Pineal Gland|Pineal Epidermoid Cyst|Pineal Epidermoid Cysts
C5418	Pleural_Schwannoma	Peripheral_Nerve_Schwannoma	Pleural Schwannoma|Neurilemmoma of Pleura|Neurilemmoma of the Pleura|Pleural Neurilemmoma|Schwannoma of Pleura|Schwannoma of the Pleura
C5419	Gliofibroma	Astrocytic_Tumor	Gliofibroma	An astrocytic tumor affecting young people.  Morphologically, it is characterized by the presence of collagenous tissue surrounding neoplastic astrocytes.  In some cases the collagen is produced by the tumor cells (desmoplastic astrocytoma), whereas in others it is produced by mesenchymal cells (mixed glioma/fibroma). --2004
C5420	Paraneoplastic_Subacute_Sensory_Neuronopathy	Paraneoplastic_Polyneuropathy	Paraneoplastic Subacute Sensory Neuronopathy|Paraneoplastic Subacute Sensory Neuropathy
C5421	Sympathetic_Schwannoma	Autonomic_Nervous_System_Neoplasm|Schwannoma	Sympathetic Schwannoma|Sympathetic Neurilemmoma	A benign tumor derived from schwann cells of the peripheral sympathetic nervous system, including the sympathetic plexus.
C5423	Cervicomedullary_Junction_Neoplasm	Infratentorial_Neoplasm	Cervicomedullary Junction Neoplasm|Cervicomedullary Junction Neoplasms|Cervicomedullary Junction Tumor|Neoplasm of Cervicomedullary Junction|Neoplasm of the Cervicomedullary Junction|Tumor of Cervicomedullary Junction|Tumor of the Cervicomedullary Junction
C5424	Epidural_Spinal_Canal_Angiolipoma	Angiolipoma|Epidural_Spinal_Canal_Neoplasm	Epidural Spinal Canal Angiolipoma|Angiolipoma of Epidural Spinal Canal|Angiolipoma of Extradural Spinal Canal|Angiolipoma of the Epidural Spinal Canal|Angiolipoma of the Extradural Spinal Canal|Extradural Spinal canal Angiolipoma
C5426	Clivus_Chondroid_Chordoma	Chondroid_Chordoma|Clival_Chordoma	Clivus Chondroid Chordoma|Chondroid Chordoma of Clivus|Chondroid Chordoma of the Clivus
C5427	Retroperitoneal_Ganglioneuroma	Ganglioneuroma	Retroperitoneal Ganglioneuroma|Ganglioneuroma of Retroperitoneum|Ganglioneuroma of the Retroperitoneum
C5428	Intramedullary_Spinal_Cord_Teratoma	Central_Nervous_System_Teratoma|Spinal_Cord_Neoplasm	Intramedullary Spinal Cord Teratoma|Intramedullary Spinal Teratoma|Intramedullary Teratoma of Spinal Cord|Intramedullary Teratoma of the Spinal Cord
C5429	Childhood_Mediastinal_Neurogenic_Neoplasm	Childhood_Neoplasm|Mediastinal_Neural_Neoplasm|Peripheral_Nervous_System_Neoplasm	Childhood Mediastinal Neurogenic Neoplasm|Childhood Mediastinal Neurogenic Tumor|Childhood Neurogenic Neoplasm of Mediastinum|Childhood Neurogenic Neoplasm of the Mediastinum|Childhood Neurogenic Tumor of Mediastinum|Childhood Neurogenic Tumor of the Mediastinum|Pediatric Mediastinal Neurogenic Neoplasm|Pediatric Mediastinal Neurogenic Tumor|Pediatric Neurogenic Neoplasm of Mediastinum|Pediatric Neurogenic Neoplasm of the Mediastinum|Pediatric Neurogenic Tumor of Mediastinum|Pediatric Neurogenic Tumor of the Mediastinum
C5430	Intracranial_Germinoma	Germinoma|Malignant_Intracranial_Germ_Cell_Neoplasm	Intracranial Germinoma
C5431	Peripheral_Nerve_Fibrolipomatous_Hamartoma	Mesenchymal_Hamartoma|Non-Neoplastic_Peripheral_Nervous_System_Disorder	Peripheral Nerve Fibrolipomatous Hamartoma|Fibrolipomatous Hamartoma of Peripheral Nerve
C5432	Intracranial_Cavernous_Hemangioma	Cavernous_Hemangioma|Intracranial_Hemangioma	Intracranial Cavernous Hemangioma|Intracranial Cavernoma|Intracranial Cavernous Angioma
C5433	Cerebral_Hemangioma	Benign_Cerebral_Neoplasm|Brain_Hemangioma	Cerebral Hemangioma|Angioma of Cerebral Hemispheres|Angioma of Cerebrum|Angioma of the Cerebral Hemispheres|Angioma of the Cerebrum|Cerebral Angioma|Cerebral Hemispheric Angioma|Cerebral Hemispheric Hemangioma|Hemangioma of Cerebral Hemispheres|Hemangioma of Cerebrum|Hemangioma of the Cerebral Hemispheres|Hemangioma of the Cerebrum
C5434	Schwannoma_of_the_Twelfth_Cranial_Nerve	Hypoglossal_Nerve_Neoplasm|Schwannoma	Schwannoma of the Twelfth Cranial Nerve|Hypoglossal Nerve Neurilemmoma|Hypoglossal Nerve Schwannoma|Hypoglossal Neurilemmoma|Hypoglossal Schwannoma|Neurilemmoma of Hypoglossal Nerve|Neurilemmoma of Twelfth Cranial Nerve|Neurilemmoma of the Hypoglossal Nerve|Neurilemmoma of the Twelfth Cranial Nerve|Schwannoma of Hypoglossal Nerve|Schwannoma of Twelfth Cranial Nerve|Schwannoma of the Hypoglossal Nerve|Twelfth Cranial Nerve Neurilemmoma|Twelfth Cranial Nerve Schwannoma
C5435	Kadish_Stage_C_Olfactory_Neuroblastoma	Olfactory_Neuroblastoma	Kadish Stage C Olfactory Neuroblastoma
C5436	Cerebellopontine_Angle_Primitive_Neuroectodermal_Tumor	Central_Nervous_System_Primitive_Neuroectodermal_Tumor|Cerebellopontine_Angle_Neoplasm|Intracranial_Primitive_Neuroectodermal_Neoplasm|Malignant_Infratentorial_Neoplasm	Cerebellopontine Angle Primitive Neuroectodermal Tumor|C-P Angle PNET|C-P Angle Primitive Neuroectodermal Neoplasm|C-P Angle Primitive Neuroectodermal Tumor|Cerebellar Pontine Angle PNET|Cerebellar Pontine Angle Primitive Neuroectodermal Neoplasm|Cerebellar Pontine Angle Primitive Neuroectodermal Tumor|Cerebellopontine Angle PNET|Cerebellopontine Angle Primitive Neuroectodermal Neoplasm|Primitive Neuroectodermal Neoplasm of C-P Angle|Primitive Neuroectodermal Neoplasm of Cerebellar Pontine Angle|Primitive Neuroectodermal Neoplasm of Cerebellopontine Angle|Primitive Neuroectodermal Neoplasm of the C-P Angle|Primitive Neuroectodermal Neoplasm of the Cerebellar Pontine Angle|Primitive Neuroectodermal Neoplasm of the Cerebellopontine Angle|Primitive Neuroectodermal Tumor of C-P Angle|Primitive Neuroectodermal Tumor of Cerebellar Pontine Angle|Primitive Neuroectodermal Tumor of Cerebellopontine Angle|Primitive Neuroectodermal Tumor of the C-P Angle|Primitive Neuroectodermal Tumor of the Cerebellar Pontine Angle|Primitive Neuroectodermal Tumor of the Cerebellopontine Angle
C5437	Extracranial_Neuroblastoma	Neuroblastoma	Extracranial Neuroblastoma
C5438	Corpus_Callosum_Lipoma	Cerebral_Hemisphere_Lipoma	Corpus Callosum Lipoma|Lipoma of Corpus Callosum|Lipoma of the Corpus Callosum
C5439	Drop_Metastasis_to_Spinal_Cord	Metastasis_to_Spinal_Cord	Drop Metastasis to Spinal Cord|Drop Metastatic Neoplasm to the Spinal Cord|Drop Metastatic Tumor to the Spinal Cord|Drop Secondary Malignant Neoplasm to the Spinal Cord|Drop Secondary Malignant Tumor to the Spinal Cord
C5440	Central_Nervous_System_Leukemia	Central_Nervous_System_Hematopoietic_Neoplasm|Leukemia	Central Nervous System Leukemia|CNS Leukemia|Leukemia of CNS|Leukemia of Central Nervous System|Leukemia of the CNS|Leukemia of the Central Nervous System
C5441	Central_Nervous_System_Teratoma	Central_Nervous_System_Germ_Cell_Neoplasm|Teratoma	Central Nervous System Teratoma|CNS Teratoma|Teratoma of CNS|Teratoma of Central Nervous System|Teratoma of the CNS|Teratoma of the Central Nervous System	Teratomas are tumors that differentiate along ectodermal, endodermal and mesodermal lines - they recapitulate somatic development from the three embryonic germ layers. There are mature and immature variants. (Adapted from WHO.)
C5442	Intracranial_Melanoma	Central_Nervous_System_Melanoma|Malignant_Intracranial_Neoplasms_By_Morphology	Intracranial Melanoma
C5443	Conus_Medullaris_Neoplasm	Spinal_Cord_Neoplasm	Conus Medullaris Neoplasm|Conus Medullaris Tumor|Neoplasm of Conus Medullaris|Neoplasm of the Conus Medullaris|Tumor of Conus Medullaris|Tumor of the Conus Medullaris
C5444	Intracranial_Lipoma	Benign_Intracranial_Neoplasm|Central_Nervous_System_Lipoma	Intracranial Lipoma
C5445	Central_Nervous_System_Colloid_Cyst	Central_Nervous_System_Cyst	Central Nervous System Colloid Cyst|CNS Colloid Cyst|CNS Hypophyseal Cyst|CNS Neuroepithelial Cyst|CNS Neuroepithelial Cysts|Central Nervous System Hypophyseal Cyst|Central Nervous System Neuroepithelial Cyst|Central Nervous System Neuroepithelial Cysts|Central Nervous System Neuroglial Cyst|Colloid Cyst of CNS|Colloid Cyst of Central Nervous System|Colloid Cyst of the CNS|Colloid Cyst of the Central Nervous System|Hypophyseal Cyst of CNS|Hypophyseal Cyst of Central Nervous System|Hypophyseal Cyst of the CNS|Hypophyseal Cyst of the Central Nervous System|Neuroepithelial Cyst of CNS|Neuroepithelial Cyst of Central Nervous System|Neuroepithelial Cyst of the CNS|Neuroepithelial Cyst of the Central Nervous System
C5446	Meningeal_Gliomatosis	Malignant_Neoplasms_of_the_Meninges|Neuroglial_Tumor	Meningeal Gliomatosis|Gliomatosis of Meninges|Gliomatosis of the Meninges|Meninges Gliomatosis
C5447	Childhood_Anaplastic_Oligodendroglioma	Anaplastic_Oligodendroglioma|Malignant_Childhood_Central_Nervous_System_Neoplasm	Childhood Anaplastic Oligodendroglioma|Anaplastic Childhood Oligodendroglioma|Anaplastic Pediatric Oligodendroglioma|Undifferentiated Childhood Oligodendroglioma|Undifferentiated Pediatric Oligodendroglioma
C5448	Malignant_Childhood_Central_Nervous_System_Neoplasm	Childhood_Central_Nervous_System_Neoplasm	Malignant Childhood Central Nervous System Neoplasm|Childhood Malignant CNS Neoplasms|Childhood Malignant CNS Tumors|Childhood Malignant Central Nervous System Neoplasms|Childhood Malignant Central Nervous System Tumors|Malignant Central Nervous System Neoplasms of Childhood|Malignant Central Nervous System Tumors of Childhood|Malignant Childhood CNS Neoplasm|Malignant Childhood CNS Tumor|Malignant Childhood Central Nervous System Neoplasms|Malignant Childhood Central Nervous System Tumor|Malignant Childhood Central Nervous System Tumors|Malignant Childhood Neoplasm of CNS|Malignant Childhood Neoplasm of Central Nervous System|Malignant Childhood Neoplasm of the CNS|Malignant Childhood Neoplasm of the Central Nervous System|Malignant Childhood Tumor of CNS|Malignant Childhood Tumor of Central Nervous System|Malignant Childhood Tumor of the CNS|Malignant Childhood Tumor of the Central Nervous System|Malignant Pediatric CNS Neoplasm|Malignant Pediatric CNS Tumor|Malignant Pediatric Central Nervous System Neoplasm|Malignant Pediatric Central Nervous System Tumor|Malignant Pediatric Neoplasm of CNS|Malignant Pediatric Neoplasm of Central Nervous System|Malignant Pediatric Neoplasm of the CNS|Malignant Pediatric Neoplasm of the Central Nervous System|Malignant Pediatric Tumor of CNS|Malignant Pediatric Tumor of Central Nervous System|Malignant Pediatric Tumor of the CNS|Malignant Pediatric Tumor of the Central Nervous System	Malignant neoplasms which occur in the brain, spinal cord, or meninges of children.  Brainstem gliomas, medulloblastomas, ependymomas, and certain pineal tumors are relatively common primary malignant tumors of the CNS in children.  (KEV 8-13-99)
C5449	Central_Nervous_System_Soft_Tissue_Neoplasm	Central_Nervous_System_Neoplasm|Soft_Tissue_Neoplasm	Central Nervous System Soft Tissue Neoplasm|CNS Soft Tissue Neoplasm|CNS Soft Tissue Tumor|Central Nervous System Soft Tissue Tumor|Soft Tissue Neoplasm of CNS|Soft Tissue Neoplasm of Central Nervous System|Soft Tissue Neoplasm of the CNS|Soft Tissue Neoplasm of the Central Nervous System|Soft Tissue Tumor of CNS|Soft Tissue Tumor of Central Nervous System|Soft Tissue Tumor of the CNS|Soft Tissue Tumor of the Central Nervous System
C5450	Central_Nervous_System_Angiosarcoma	Angiosarcoma|Central_Nervous_System_Sarcoma	Central Nervous System Angiosarcoma|Angiosarcoma of CNS|Angiosarcoma of Central Nervous System|Angiosarcoma of the CNS|Angiosarcoma of the Central Nervous System|CNS Angiosarcoma|CNS Hemangiosarcoma|Central Nervous System Hemangiosarcoma|Hemangiosarcoma of CNS|Hemangiosarcoma of Central Nervous System|Hemangiosarcoma of the CNS|Hemangiosarcoma of the Central Nervous System	Angiosarcoma is a malignant endothelial neoplasm characterized by an atypical, multilayered or solid endothelial proliferation and a vascular architecture. Rare cases originate in brain or meninges and their differentiation vary from patently vascular tumors with anastomosing vascular channels lined by mitotically active, cytologically atypical endothelial cells, to poorly differentiated, often epithelioid, lesions in which immunohistochemical and ultrastructural studies are required for a definitive diagnosis. (Adapted from WHO.)
C5451	Central_Nervous_System_Lipoma	Benign_Central_Nervous_System_Soft_Tissue_Neoplasm|Lipoma|Mesenchymal_Non-Meningothelial_Tumor_of_the_Central_Nervous_System	Central Nervous System Lipoma|CNS Lipoma|Lipoma of CNS|Lipoma of Central Nervous System|Lipoma of the CNS|Lipoma of the Central Nervous System	Lipoma is a benign lesion that, histologically, resembles normal adipose tissue. Epidural lipomas tend to be delicately encapsulated and discrete, while intradural tumors are often intimately attached to the leptomeninges and CNS parenchyma. (Adapted from WHO.)
C5452	Internal_Auditory_Canal_Lipoma	Benign_Ear_Neoplasm|Intracranial_Lipoma	Internal Auditory Canal Lipoma|Lipoma of Internal Auditory Canal|Lipoma of the Internal Auditory Canal
C5453	Skull_Base_Chordoma	Chordoma|Skull_Base_Neoplasm	Skull Base Chordoma|Chordoma of Skull Base|Chordoma of the Skull Base
C5454	Stage_IIA_Breast_Cancer	Stage_II_Breast_Cancer	Stage IIA Breast Cancer|Breast Cancer Stage IIA|Breast Carcinoma Stage IIA|Stage IIA Breast Carcinoma
C5455	Stage_IIB_Breast_Cancer	Stage_II_Breast_Cancer	Stage IIB Breast Cancer|Breast Cancer Stage IIB|Breast Carcinoma Stage IIB|Stage IIB Breast Carcinoma
C5456	Tubular_Breast_Adenosis	Retired_Concepts	Tubular Breast Adenosis|Tubular Adenosis of Breast|Tubular Adenosis of the Breast
C5457	Invasive_Apocrine_Breast_Carcinoma	Apocrine_Ductal_Breast_Carcinoma|Invasive_Breast_Carcinoma	Invasive Apocrine Breast Carcinoma|Infiltrating Apocrine Breast Carcinoma|Infiltrating Apocrine Carcinoma of Breast|Infiltrating Apocrine Carcinoma of the Breast|Invasive Apocrine Carcinoma of Breast|Invasive Apocrine Carcinoma of the Breast
C5460	Malignant_Mixed_Breast_Neoplasm	Retired_Concepts	Malignant Mixed Breast Neoplasm|Malignant Mixed Breast Tumor|Malignant Mixed Neoplasm of the Breast|Malignant Mixed Tumor of the Breast|Mixed Malignant Breast Neoplasm|Mixed Malignant Breast Tumor|Mixed Malignant Neoplasm of the Breast|Mixed Malignant Tumor of the Breast
C5461	Central_Nervous_System_Germ_Cell_Neoplasm	Central_Nervous_System_Neoplasm|Extragonadal_Germ_Cell_Neoplasm	Central Nervous System Germ Cell Tumor|CNS Germ Cell Neoplasm|CNS Germ Cell Tumor|Central Nervous System Germ Cell Neoplasm|Germ Cell Neoplasm of CNS|Germ Cell Neoplasm of Central Nervous System|Germ Cell Neoplasm of the CNS|Germ Cell Neoplasm of the Central Nervous System|Germ Cell Tumor of CNS|Germ Cell Tumor of Central Nervous System|Germ Cell Tumor of the CNS|Germ Cell Tumor of the Central Nervous System	Germ Cell Tumors of the CNS constitute a unique class of rare tumors that affect mainly children and adolescents. Their histopathological and biological profile largely corresponds to that of homologous germ cell neoplasms arising in the gonads and in other extragonadal sites. Germ Cell Tumors of the CNS include: Germinoma, Embryonal Carcinoma, Yolk Sac Tumor (Endodermal Sinus Tumor), Choriocarcinoma, Mature Teratoma, Immature Teratoma, Teratoma with Malignant Transformation and Mixed Germ Cell Tumors. (Adapted from WHO.)
C5462	Intracranial_Chondrosarcoma	Central_Nervous_System_Sarcoma|Extraskeletal_Chondrosarcoma|Malignant_Intracranial_Neoplasms_By_Morphology	Intracranial Chondrosarcoma
C5464	Central_Nervous_System_Rhabdomyosarcoma	Central_Nervous_System_Sarcoma|Rhabdomyosarcoma	Central Nervous System Rhabdomyosarcoma|CNS Rhabdomyosarcoma|Rhabdomyosarcoma of CNS|Rhabdomyosarcoma of Central Nervous System|Rhabdomyosarcoma of the CNS|Rhabdomyosarcoma of the Central Nervous System	CNS Rhabdomyosarcomas are malignant tumors (sarcomas) derived from striated muscle. Microscopically, strap cells, which have cross striations, may be observed but most tumors consist primarily of small cells that show little or no specific differentiation. Therefore, immunohistochemistry and/or electron microscopy may be necessary for diagnosis. Rhabdomyosarcomas must be differentiated from other brain tumors that occasionally show skeletal muscle elements, such as medullomyoblastoma, gliosarcoma and gem-cell tumors. Malignant ectomesenchymoma, a mixed tumor composed of ganglion cells or neuroblasts and one or more mesenchymal elements, usually rhabdomyosarcoma, may also occur in the brain. (Adapted from WHO.)
C5465	Central_Nervous_System_Fibrosarcoma	Central_Nervous_System_Sarcoma|Soft_Tissue_Fibrosarcoma	Central Nervous System Fibrosarcoma|CNS Fibrosarcoma|Fibrosarcoma of CNS|Fibrosarcoma of Central Nervous System|Fibrosarcoma of the CNS|Fibrosarcoma of the Central Nervous System	A rare, malignant tumor of the central nervous system showing interlacing bundles of spindle cells in a herringbone pattern. Fibrosarcomas are very cellular and have high mitotic activity and often necrosis. (Adapted from WHO.)
C5466	Central_Nervous_System_Paraganglioma	Central_Nervous_System_Neoplasm|Extra-Adrenal_Paraganglioma	Central Nervous System Paraganglioma|CNS Paraganglioma|Paraganglioma of CNS|Paraganglioma of Central Nervous System|Paraganglioma of the CNS|Paraganglioma of the Central Nervous System	A benign or malignant extra-adrenal paraganglioma arising from the central nervous system.
C5468	Stage_IA_Gastric_Cancer	Stage_I_Gastric_Cancer	Stage IA Gastric Cancer|Carcinoma of Stomach Stage IA|Carcinoma of the Stomach Stage IA|Gastric Cancer Stage IA|Gastric Carcinoma Stage IA|Stage IA Carcinoma of Stomach|Stage IA Carcinoma of the Stomach|Stage IA Gastric Carcinoma|Stage IA Stomach Carcinoma|Stomach Carcinoma Stage IA
C5469	Stage_IB_Gastric_Cancer	Stage_I_Gastric_Cancer	Stage IB Gastric Cancer|Carcinoma of Stomach Stage IB|Carcinoma of the Stomach Stage IB|Gastric Cancer Stage IB|Gastric Carcinoma Stage IB|Stage IB Carcinoma of Stomach|Stage IB Carcinoma of the Stomach|Stage IB Gastric Carcinoma|Stage IB Stomach Carcinoma|Stomach Carcinoma Stage IB
C5470	Stage_IIIB_Gastric_Cancer	Stage_III_Gastric_Cancer	Stage IIIB Gastric Cancer|Carcinoma of Stomach Stage IIIB|Carcinoma of the Stomach Stage IIIB|Gastric Cancer Stage IIIB|Gastric Carcinoma Stage IIIB|Stage IIIB Carcinoma of Stomach|Stage IIIB Carcinoma of the Stomach|Stage IIIB Gastric Carcinoma|Stage IIIB Stomach Carcinoma|Stomach Carcinoma Stage IIIB
C5471	Stage_IIIA_Gastric_Cancer	Stage_III_Gastric_Cancer	Stage IIIA Gastric Cancer|Carcinoma of Stomach Stage IIIA|Carcinoma of the Stomach Stage IIIA|Gastric Cancer Stage IIIA|Gastric Carcinoma Stage IIIA|Stage IIIA Carcinoma of Stomach|Stage IIIA Carcinoma of the Stomach|Stage IIIA Gastric Carcinoma|Stage IIIA Stomach Carcinoma|Stomach Carcinoma Stage IIIA
C5472	Gastric_Papillary_Adenocarcinoma	Papillary_Adenocarcinoma|Sporadic_Gastric_Carcinoma	Gastric Papillary Adenocarcinoma|Papillary Adenocarcinoma of Stomach|Papillary Adenocarcinoma of the Stomach	A variant of gastric adenocarcinoma with exophytic growth and elongated finger-like processes lined by cylindrical or cuboidal cells supported by fibrovascular connective tissue cores.  -- 2003
C5473	Gastric_Tubular_Adenocarcinoma	Sporadic_Gastric_Carcinoma|Tubular_Adenocarcinoma	Gastric Tubular Adenocarcinoma|Tubular Adenocarcinoma of Stomach|Tubular Adenocarcinoma of the Stomach	A variant of gastric adenocarcinoma characterized by prominent dilated or slit-like tubules. --2003
C5474	Gastric_Adenosquamous_Carcinoma	Adenosquamous_Carcinoma|Gastric_Carcinoma	Gastric Adenosquamous Carcinoma|Adenosquamous Carcinoma of Stomach|Adenosquamous Carcinoma of the Stomach	A carcinoma that combines an adenocarcinoma and squamous cell carcinoma.  -- 2003
C5475	Gastric_Squamous_Cell_Carcinoma	Gastric_Carcinoma|Squamous_Cell_Carcinoma	Gastric Squamous Cell Carcinoma|Squamous Cell Carcinoma of Stomach|Squamous Cell Carcinoma of the Stomach	A rare carcinoma of the stomach resembling squamous cell carcinomas arising elsewhere in the body.  -- 2003
C5476	Undifferentiated_Gastric_Carcinoma	Gastric_Carcinoma|Undifferentiated_Carcinoma	Undifferentiated Gastric Carcinoma|Anaplastic Carcinoma of Stomach|Anaplastic Carcinoma of the Stomach|Anaplastic Gastric Carcinoma|Undifferentiated Carcinoma of Stomach|Undifferentiated Carcinoma of the Stomach
C5478	Adult_Intracranial_Neoplasm	Adult_Central_Nervous_System_Neoplasm|Intracranial_Neoplasm	Adult Intracranial Neoplasm|Adult Intracranial Neoplasms|Adult Intracranial Tumor
C5479	Cauda_Equina_Neoplasm	Intraspinal_Neoplasm	Cauda Equina Neoplasm|Cauda Equina Neoplasms|Cauda Equina Tumor|Neoplasm of Cauda Equina|Neoplasm of the Cauda Equina|Tumor of Cauda Equina|Tumor of the Cauda Equina
C5481	Gastric_Hemangioma	Benign_Gastric_Mesenchymal_Neoplasm|Gastrointestinal_Hemangioma|Intra-Abdominal_Hemangioma	Gastric Hemangioma|Angioma of Stomach|Angioma of the Stomach|Gastric Angioma|Hemangioma of Stomach|Hemangioma of the Stomach
C5482	Gastric_Lymphangioma	Benign_Gastric_Mesenchymal_Neoplasm|Lymphangioma	Gastric Lymphangioma|Lymphangioma of Stomach|Lymphangioma of the Stomach
C5483	Benign_Gastric_Granular_Cell_Tumor	Benign_Gastric_Neoplasm|Benign_Granular_Cell_Tumor	Benign Gastric Granular Cell Tumor|Benign Gastric Granular Cell Neoplasm|Benign Granular Cell Neoplasm of Stomach|Benign Granular Cell Neoplasm of the Stomach|Benign Granular Cell Stomach Neoplasm|Benign Granular Cell Stomach Tumor|Benign Granular Cell Tumor of Stomach|Benign Granular Cell Tumor of the Stomach|Gastric Myoblastoma|Myoblastoma of Stomach|Myoblastoma of the Stomach
C5484	Malignant_Gastric_Granular_Cell_Tumor	Malignant_Gastric_Neoplasm|Malignant_Granular_Cell_Tumor	Malignant Gastric Granular Cell Tumor|Malignant Gastric Granular Cell Neoplasm|Malignant Granular Cell Neoplasm of Stomach|Malignant Granular Cell Neoplasm of the Stomach|Malignant Granular Cell Stomach Neoplasm|Malignant Granular Cell Stomach Tumor|Malignant Granular Cell Tumor of Stomach|Malignant Granular Cell Tumor of the Stomach
C5486	Malignant_Gastric_Germ_Cell_Neoplasm	Gastric_Germ_Cell_Neoplasm|Malignant_Extragonadal_Germ_Cell_Tumor|Malignant_Gastric_Neoplasm	Malignant Gastric Germ Cell Tumor|Malignant Gastric Germ Cell Neoplasm|Malignant Germ Cell Neoplasm of Stomach|Malignant Germ Cell Neoplasm of the Stomach|Malignant Germ Cell Tumor of Stomach|Malignant Germ Cell Tumor of the Stomach
C5487	Gastric_Mesenchymal_Neoplasm	Gastric_Neoplasm|Soft_Tissue_Neoplasm	Gastric Mesenchymal Neoplasm|Gastric Mesenchymal Tumor|Mesenchymal Neoplasm of Stomach|Mesenchymal Neoplasm of the Stomach|Mesenchymal Tumor of Stomach|Mesenchymal Tumor of the Stomach
C5488	Gastric_Liposarcoma	Liposarcoma|Malignant_Gastric_Mesenchymal_Neoplasm	Gastric Liposarcoma|Liposarcoma of Stomach|Liposarcoma of the Stomach|Stomach Liposarcoma
C5489	Gastric_Xanthoma	Benign_Gastric_Mesenchymal_Neoplasm|Xanthoma	Gastric Xanthoma|Gastric Xanthelasma|Xanthoma of Stomach|Xanthoma of the Stomach
C5490	Colon_Squamous_Cell_Carcinoma	Colon_Carcinoma|Colorectal_Squamous_Cell_Carcinoma	Colon Squamous Cell Carcinoma|Colon Epidermoid Carcinoma|Colonic Epidermoid Carcinoma|Colonic Squamous Cell Carcinoma|Epidermoid Carcinoma of Colon|Epidermoid Carcinoma of the Colon|Squamous Cell Carcinoma of Colon|Squamous Cell Carcinoma of the Colon|Squamous Cell Colon Carcinoma
C5491	Colon_Adenosquamous_Carcinoma	Colon_Carcinoma|Colorectal_Adenosquamous_Carcinoma	Colon Adenosquamous Carcinoma|Adenosquamous Carcinoma of Colon|Adenosquamous Carcinoma of the Colon|Adenosquamous Colon Carcinoma|Colonic Adenosquamous Carcinoma
C5492	Colon_Leiomyoma	Benign_Colon_Neoplasm|Colorectal_Leiomyoma	Colon Leiomyoma|Colonic Leiomyoma|Leiomyoma of Colon|Leiomyoma of the Colon
C5493	Colon_Lipoma	Benign_Colon_Neoplasm|Colorectal_Lipoma	Colon Lipoma|Colonic Lipoma|Lipoma of Colon|Lipoma of the Colon
C5494	Colon_Leiomyosarcoma	Colon_Sarcoma|Leiomyosarcoma	Colon Leiomyosarcoma|Colonic Leiomyosarcoma|Leiomyosarcoma of Colon|Leiomyosarcoma of the Colon
C5495	Colon_Sarcoma	Malignant_Colon_Neoplasm|Soft_Tissue_Sarcoma	Colon Sarcoma|Colonic Sarcoma|Sarcoma of Colon|Sarcoma of the Colon
C5496	Colon_Tubulovillous_Adenoma	Colonic_Adenoma|Colorectal_Tubulovillous_Adenoma	Colon Tubulovillous Adenoma|Colonic Tubulovillous Adenoma|Tubulovillous Adenoma of Colon|Tubulovillous Adenoma of the Colon
C5497	Colon_Carcinoid_Tumor	Colon_Neuroendocrine_Neoplasm|Intestinal_Carcinoid_Tumor	Colon Carcinoid Tumor|Carcinoid Neoplasm of Colon|Carcinoid Neoplasm of the Colon|Carcinoid Tumor of Colon|Carcinoid Tumor of the Colon|Colon Carcinoid Neoplasm|Colonic Carcinoid Neoplasm|Colonic Carcinoid Tumor	A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract; approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell.
C5498	Colon_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Colon_Non-Hodgkin_s_Lymphoma|Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue	Colon Mucosa-Associated Lymphoid Tissue Lymphoma|Colon MALT Lymphoma|Colon MALToma|Colonic MALT Lymphoma|Colonic MALToma|Colonic Mucosa-Associated Lymphoid Tissue Lymphoma|MALT Lymphoma of Colon|MALT Lymphoma of the Colon|MALToma of Colon|MALToma of the Colon
C5499	Colon_Hodgkin_s_Lymphoma	Colon_Lymphoma|Gastrointestinal_Hodgkin_s_Lymphoma	Colon Hodgkin's Lymphoma|Colon Hodgkin Lymphoma|Colon Hodgkin's Disease|Colon Hodgkins Disease|Colon Hodgkins Lymphoma|Colonic Hodgkin's Disease|Colonic Hodgkin's Lymphoma|Hodgkin's Lymphoma of Colon|Hodgkin's Lymphoma of the Colon|Primary Colon Hodgkin's Lymphoma
C5500	Colon_Lymphangioma	Benign_Colon_Neoplasm|Intra-Abdominal_Lymphangioma	Colon Lymphangioma|Colonic Lymphangioma|Lymphangioma of Colon|Lymphangioma of the Colon
C5501	Cecum_Carcinoid_Tumor	Colon_Carcinoid_Tumor|Malignant_Cecum_Neoplasm|Midgut_Carcinoid_Tumor	Cecum Carcinoid Tumor|Caecal Carcinoid Tumor|Caecum Carcinoid Tumor|Carcinoid Neoplasm of Cecum|Carcinoid Neoplasm of the Cecum|Carcinoid Tumor of Cecum|Carcinoid Tumor of the Cecum|Cecal Carcinoid Neoplasm|Cecal Carcinoid Tumor
C5502	Benign_Peripheral_Nerve_Granular_Cell_Tumor	Benign_Granular_Cell_Tumor	Benign Peripheral Nerve Granular Cell Tumor|Benign Granular Cell Neoplasm of Peripheral Nerve|Benign Granular Cell Neoplasm of the Peripheral Nerve|Benign Granular Cell Tumor of Peripheral Nerve|Benign Granular Cell Tumor of the Peripheral Nerve|Benign Peripheral Nerve Granular Cell Neoplasm
C5503	Central_Nervous_System_Hematopoietic_Neoplasm	Central_Nervous_System_Neoplasm|Hematopoietic_Cell_Neoplasm	Central Nervous System Hematopoietic Neoplasm|CNS Hematopoietic Neoplasm|CNS Hematopoietic Tumor|Central Nervous System Hematopoietic Neoplasms|Central Nervous System Hematopoietic Tumor|Hematopoietic Neoplasm of CNS|Hematopoietic Neoplasm of Central Nervous System|Hematopoietic Neoplasm of the CNS|Hematopoietic Neoplasm of the Central Nervous System|Hematopoietic Tumor of Central Nervous System|Hematopoietic Tumor of the Central Nervous System|Lymphomas and Hemopoietic Neoplasms of CNS|Lymphomas and Hemopoietic Neoplasms of the CNS
C5504	Central_Nervous_System_Melanocytic_Neoplasm	Central_Nervous_System_Neoplasm|Melanocytic_Neoplasm	Central Nervous System Melanocytic Neoplasm|CNS Melanocytic Neoplasm|CNS Melanocytic Tumor|Central Nervous System Melanocytic Neoplasms|Central Nervous System Melanocytic Tumor|Melanocytic Neoplasm of CNS|Melanocytic Neoplasm of Central Nervous System|Melanocytic Neoplasm of the CNS|Melanocytic Neoplasm of the Central Nervous System|Melanocytic Tumor of CNS|Melanocytic Tumor of Central Nervous System|Melanocytic Tumor of the CNS|Melanocytic Tumor of the Central Nervous System	Primary tumors of the central nervous system which arise from leptomeningeal melanocytes.  These tumors may present as diffuse proliferative leptomeningeal processes (often as a component of the neurocutaneous melanosis complex) or as distinct mass lesions.
C5505	Central_Nervous_System_Melanoma	Central_Nervous_System_Melanocytic_Neoplasm	Central Nervous System Melanoma|CNS Melanoma|Melanoma of CNS|Melanoma of Central Nervous System|Melanoma of the CNS|Melanoma of the Central Nervous System	Primary Meningeal Malignant Melanomas show considerable pleomorphism, with large, and bizarre tumor cells, including multinucleated giant cells, and a variable amount of melanin pigment. High mitotic rate, necrosis, hemorrhage and invasion of brain or spinal cord parenchyma is common. Malignant Melanoma is a highly aggressive and radioresistant tumor with poor prognosis and may metastasize to remote organs. (WHO)
C5506	Endodermal_Cyst	Central_Nervous_System_Cyst	Endodermal Cyst|Cyst of Endoderm|Cyst of the Endoderm|Endodermal Cysts
C5507	Central_Nervous_System_Epidermoid_Cyst	Central_Nervous_System_Cyst	Central Nervous System Epidermoid Cyst|CNS Epidermoid Cyst|CNS Epidermoid Neoplasm|CNS Epidermoid Tumor|Central Nervous System Epidermoid Neoplasm|Central Nervous System Epidermoid Tumor|Epidermoid Cyst of CNS|Epidermoid Cyst of Central Nervous System|Epidermoid Cyst of the CNS|Epidermoid Cyst of the Central Nervous System|Epidermoid Neoplasm of CNS|Epidermoid Neoplasm of Central Nervous System|Epidermoid Neoplasm of the CNS|Epidermoid Neoplasm of the Central Nervous System|Epidermoid Tumor of CNS|Epidermoid Tumor of Central Nervous System|Epidermoid Tumor of the CNS|Epidermoid Tumor of the Central Nervous System	A lesion which is characterized by an irregularly nodular opalescent wall which has caused it to be termed a "pearly tumor". The Intramural contents are soft and waxy with a variable amount of cholesterol.
C5508	Central_Nervous_System_Dermoid_Cyst	Central_Nervous_System_Teratoma|Dermoid_Cyst	Central Nervous System Dermoid Cyst|CNS Dermoid Cyst|Dermoid Cyst of CNS|Dermoid Cyst of Central Nervous System|Dermoid Cyst of the CNS|Dermoid Cyst of the Central Nervous System	A multilobular lesion, characterized by a thick wall. The Intramural contents are soft and waxy with a variable amount of cholesterol. Teeth are rarely present though hair is not uncommon.
C5509	Central_Nervous_System_Hamartoma	Hamartoma|Non-Neoplastic_Central_Nervous_System_Disorder	Central Nervous System Hamartoma|CNS Hamartoma|Hamartoma of CNS|Hamartoma of Central Nervous System|Hamartoma of the CNS|Hamartoma of the Central Nervous System
C5510	Benign_Mucinous_Appendix_Cystadenoma	Appendix_Adenoma|Mucinous_Cystadenoma	Appendix Mucinous Cystadenoma|Colloid Appendiceal Cystadenoma|Colloid Cystadenoma of Appendix|Colloid Cystadenoma of the Appendix|Colloidal Cystadenoma of Appendix|Mucinous Appendiceal Cystadenoma|Mucinous Appendix Cystadenoma|Mucinous Cystadenoma of Appendix|Mucinous Cystadenoma of the Appendix
C5511	Appendix_Mucinous_Cystadenocarcinoma	Low_Grade_Appendix_Mucinous_Neoplasm|Mucinous_Cystadenocarcinoma	Appendix Mucinous Cystadenocarcinoma|Appendiceal Colloid Cystadenocarcinoma|Appendiceal Colloidal Cystadenocarcinoma|Appendiceal Mucinous Cystadenocarcinoma|Appendix Colloid Cystadenocarcinoma|Appendix Colloidal Cystadenocarcinoma|Colloid Cystadenocarcinoma of Appendix|Colloid Cystadenocarcinoma of the Appendix|Colloidal Cystadenocarcinoma of Appendix|Colloidal Cystadenocarcinoma of the Appendix|Mucinous Cystadenocarcinoma of Appendix|Mucinous Cystadenocarcinoma of the Appendix
C5512	Appendix_Villous_Adenoma	Appendix_Adenoma|Villous_Adenoma	Appendix Villous Adenoma|Villous Adenoma of Appendix|Villous Adenoma of the Appendix
C5513	Appendix_Lymphoma	Gastrointestinal_Lymphoma|Malignant_Appendix_Neoplasm	Appendix Lymphoma|Appendiceal Lymphoma|Lymphoma of Appendix|Lymphoma of the Appendix|Primary Appendix Lymphoma
C5514	Appendix_Leiomyoma	Benign_Appendix_Neoplasm|Leiomyoma	Appendix Leiomyoma|Appendiceal Leiomyoma|Leiomyoma of Appendix|Leiomyoma of the Appendix
C5515	Cecum_Lymphoma	Colon_Lymphoma|Malignant_Cecum_Neoplasm	Cecum Lymphoma|Cecal Lymphoma|Lymphoma of Cecum|Lymphoma of the Cecum|Primary Cecum Lymphoma
C5516	Colon_Kaposi_s_Sarcoma	Colon_Sarcoma|Kaposi_s_Sarcoma	Colon Kaposi's Sarcoma|Colon Kaposi Sarcoma|Colon Kaposis Sarcoma|Colonic Kaposi Sarcoma|Colonic Kaposi's Sarcoma|Colonic Kaposis Sarcoma|Kaposi's Sarcoma of Colon|Kaposi's Sarcoma of the Colon
C5517	Colon_Inflammatory_Polyp	Colon_Polyp	Colon Inflammatory Polyp|Colonic Inflammatory Polyp|Inflammatory Polyp of Colon|Inflammatory Polyp of the Colon
C5518	Colon_Juvenile_Polyp	Colon_Polyp|Colorectal_Juvenile_Polyp	Colon Juvenile Polyp|Colon Retention Polyp|Colonic Juvenile Polyp|Colonic Retention Polyp|Juvenile Polyp of Colon|Juvenile Polyp of the Colon|Retention Polyp of Colon|Retention Polyp of the Colon
C5519	Colon_Hamartomatous_Polyp	Colon_Polyp|Peutz-Jeghers_Polyp	Peutz-Jeghers Colon Polyp|Colon Hamartomatous Polyp|Colonic Hamartomatous Polyp|Hamartomatous Polyp of the Colon|Hamartomatous Polyp of the Large Bowel|Large Bowel Hamartomatous Polyp|Peutz Jeghers Colon Polyp|Peutz-Jeghers Polyp of Colon|Peutz-Jeghers Polyp of the Colon
C5520	Cecum_Villous_Adenoma	Cecum_Neoplasm|Colon_Villous_Adenoma	Cecum Villous Adenoma|Cecal Villous Adenoma|Villous Adenoma of Cecum|Villous Adenoma of the Cecum
C5521	Cecum_Non-Hodgkin_s_Lymphoma	Cecum_Lymphoma|Colon_Non-Hodgkin_s_Lymphoma	Cecum Non-Hodgkin's Lymphoma|Cecal Non-Hodgkin's Lymphoma|Cecum Non-Hodgkin Lymphoma|Non-Hodgkin's Lymphoma of Cecum|Non-Hodgkin's Lymphoma of the Cecum|Primary Cecum Non-Hodgkin's Lymphoma
C5522	Prostate_Rhabdomyosarcoma	Prostate_Sarcoma|Rhabdomyosarcoma	Prostate Rhabdomyosarcoma|Rhabdomyosarcoma of Prostate|Rhabdomyosarcoma of the Prostate
C5523	Prostate_Kaposi_s_Sarcoma	Kaposi_s_Sarcoma|Prostate_Sarcoma	Prostate Kaposi's Sarcoma|Kaposi's Sarcoma of Prostate|Kaposi's Sarcoma of the Prostate
C5524	Prostate_Stromal_Sarcoma	Prostate_Sarcoma|Stromal_Sarcoma|Tumor_of_Specialized_Prostatic_Stroma	Prostate Stromal Sarcoma|Stromal Sarcoma of Prostate|Stromal Sarcoma of the Prostate
C5525	Prostate_Embryonal_Rhabdomyosarcoma	Embryonal_Rhabdomyosarcoma|Prostate_Rhabdomyosarcoma	Prostate Embryonal Rhabdomyosarcoma|Embryonal Rhabdomyosarcoma of Prostate|Embryonal Rhabdomyosarcoma of the Prostate
C5526	Prostate_Leiomyosarcoma	Leiomyosarcoma|Prostate_Sarcoma	Prostate Leiomyosarcoma|Leiomyosarcoma of Prostate|Leiomyosarcoma of the Prostate
C5527	Prostate_Myeloid_Sarcoma	Malignant_Prostate_Neoplasm|Myeloid_Sarcoma	Prostate Myeloid Sarcoma|Extramedullary Myeloid Neoplasm of Prostate|Extramedullary Myeloid Neoplasm of the Prostate|Extramedullary Myeloid Tumor of Prostate|Extramedullary Myeloid Tumor of the Prostate|Prostate Extramedullary Myeloid Neoplasm|Prostate Extramedullary Myeloid Tumor|Prostatic Chloroma|Prostatic Extramedullary Myeloid Neoplasm|Prostatic Extramedullary Myeloid Tumor|Prostatic Myeloid Sarcoma
C5528	Prostate_Angiosarcoma	Angiosarcoma|Prostate_Sarcoma	Prostate Angiosarcoma|Angiosarcoma of Prostate|Angiosarcoma of the Prostate|Hemangiosarcoma of Prostate|Hemangiosarcoma of the Prostate|Prostate Hemangiosarcoma|Prostatic Angiosarcoma|Prostatic Hemangiosarcoma
C5529	Gastric_Kaposi_s_Sarcoma	Kaposi_s_Sarcoma|Malignant_Gastric_Mesenchymal_Neoplasm	Gastric Kaposi's Sarcoma
C5530	Prostate_Sarcomatoid_Carcinoma	Acinar_Prostate_Adenocarcinoma|Sarcomatoid_Carcinoma	Acinar Prostate Adenocarcinoma, Sarcomatoid Variant|Prostate Carcinosarcoma|Prostate Sarcomatoid Carcinoma|Sarcomatoid Carcinoma of Prostate|Sarcomatoid Carcinoma of the Prostate
C5531	Malignant_Prostate_Phyllodes_Tumor	Malignant_Phyllodes_Tumor|Malignant_Prostate_Neoplasm|Phyllodes_Tumor_of_the_Prostate	Malignant Prostate Phyllodes Tumor|Malignant Phyllodes Neoplasm of Prostate|Malignant Phyllodes Neoplasm of the Prostate|Malignant Phyllodes Tumor of Prostate|Malignant Phyllodes Tumor of the Prostate|Malignant Prostate Phyllodes Neoplasm
C5532	Benign_Prostate_Phyllodes_Tumor	Benign_Phyllodes_Tumor|Benign_Prostate_Neoplasm|Phyllodes_Tumor_of_the_Prostate	Benign Prostate Phyllodes Tumor|Benign Phyllodes Neoplasm of Prostate|Benign Phyllodes Neoplasm of the Prostate|Benign Phyllodes Tumor of Prostate|Benign Phyllodes Tumor of the Prostate|Benign Prostate Phyllodes Neoplasm
C5533	Prostate_Lymphoma	Lymphoma_by_Site|Malignant_Prostate_Neoplasm	Prostate Lymphoma|Lymphoma of Prostate|Lymphoma of the Prostate|Primary Prostate Lymphoma
C5534	Prostate_Non-Hodgkin_s_Lymphoma	Non-Hodgkin_s_Lymphoma|Prostate_Lymphoma	Prostate Non-Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma of Prostate|Non-Hodgkin's Lymphoma of the Prostate|Primary Prostate Non-Hodgkin's Lymphoma|Prostate Non-Hodgkin Lymphoma
C5535	Prostate_Signet_Ring_Cell_Carcinoma	Acinar_Prostate_Adenocarcinoma|Signet_Ring_Cell_Carcinoma	Acinar Prostate Adenocarcinoma, Signet Ring Variant|Prostate Signet Ring Cell Carcinoma|Signet Ring Cell Carcinoma of Prostate|Signet Ring Cell Carcinoma of the Prostate
C5536	Prostate_Squamous_Cell_Carcinoma	Prostate_Carcinoma|Squamous_Cell_Carcinoma	Prostate Squamous Cell Carcinoma|Squamous Cell Carcinoma of Prostate|Squamous Cell Carcinoma of the Prostate
C5537	Prostate_Mucinous_Adenocarcinoma	Acinar_Prostate_Adenocarcinoma|Mucinous_Adenocarcinoma	Acinar Prostate Mucinous Adenocarcinoma|Acinar Colloid Prostate Adenocarcinoma|Colloid Adenocarcinoma of Prostate|Colloid Adenocarcinoma of the Prostate|Colloidal Adenocarcinoma of Prostate|Colloidal Adenocarcinoma of the Prostate|Colloidal Prostate Adenocarcinoma|Mucinous Adenocarcinoma of Prostate|Mucinous Adenocarcinoma of the Prostate
C5538	Prostate_Adenosquamous_Carcinoma	Adenosquamous_Carcinoma|Prostate_Carcinoma	Prostate Adenosquamous Carcinoma|Adenosquamous Carcinoma of Prostate|Adenosquamous Carcinoma of the Prostate
C5539	Prostate_Adenoid_Cystic_Carcinoma	Adenoid_Cystic_Carcinoma|Prostate_Carcinoma	Prostate Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Prostate|Adenoid Cystic Carcinoma of the Prostate
C5540	Prostate_Transitional_Cell_Carcinoma	Prostate_Carcinoma|Urothelial_Transitional_Cell_Carcinoma	Prostate Urothelial Carcinoma|Prostate Transitional Cell Carcinoma|Transitional Cell Carcinoma of Prostate|Transitional Cell Carcinoma of the Prostate
C5541	High-Grade_Prostatic_Intraepithelial_Neoplasia	High_Grade_Glandular_Intraepithelial_Neoplasia|Prostatic_Intraepithelial_Neoplasia	High Grade Prostatic Intraepithelial Neoplasia|High-Grade Intraepithelial Neoplasia of Prostate|High-Grade Intraepithelial Neoplasia of the Prostate|High-Grade PIN
C5542	Low-Grade_Prostatic_Intraepithelial_Neoplasia	Low_Grade_Glandular_Intraepithelial_Neoplasia|Prostatic_Intraepithelial_Neoplasia	Low Grade Prostatic Intraepithelial Neoplasia|Grade 1 PIN|Grade 1 Prostatic Intraepithelial Neoplasia|Grade I PIN|Grade I Prostatic Intraepithelial Neoplasia|Low-Grade Intraepithelial Neoplasia of Prostate|Low-Grade Intraepithelial Neoplasia of the Prostate|Low-Grade PIN|PIN-1
C5543	Cecum_Adenocarcinoma	Cecum_Carcinoma|Colon_Adenocarcinoma	Cecum Adenocarcinoma|Adenocarcinoma of Cecum|Adenocarcinoma of the Cecum|Cecal Adenocarcinoma
C5544	Prostate_Leiomyoma	Benign_Prostate_Neoplasm|Leiomyoma	Prostate Leiomyoma|Leiomyoma of Prostate|Leiomyoma of the Prostate|Prostatic Leiomyoma
C5545	Prostate_Neuroendocrine_Neoplasm	Neuroendocrine_Neoplasm|Prostate_Neoplasm	Prostate Neuroendocrine Neoplasm|Neuroendocrine Neoplasm of Prostate|Neuroendocrine Neoplasm of the Prostate|Neuroendocrine Tumor of Prostate|Neuroendocrine Tumor of the Prostate|Prostate Neuroendocrine Tumor
C5546	Rectal_Adenoma	Colorectal_Adenoma|Rectal_Neoplasm|Rectal_Polyp	Rectal Adenoma|Adenoma of Rectum|Adenoma of the Rectum|Adenomatous Polyp of Rectum|Adenomatous Polyp of the Rectum|Rectal Adenomatous Polyp
C5547	Rectal_Carcinoid_Tumor	Hindgut_Carcinoid_Tumor|Intestinal_Carcinoid_Tumor|Rectal_Neuroendocrine_Neoplasm	Rectal Carcinoid Tumor|Carcinoid Neoplasm of Rectum|Carcinoid Neoplasm of the Rectum|Carcinoid Tumor of Rectum|Carcinoid Tumor of the Rectum|Carcinoid of Rectum|Carcinoid of the Rectum|Rectal Carcinoid|Rectal Carcinoid Neoplasm
C5548	Rectal_Sarcoma	Malignant_Rectal_Neoplasm|Soft_Tissue_Sarcoma	Rectal Sarcoma|Sarcoma of Rectum|Sarcoma of the Rectum
C5549	Rectal_Leiomyosarcoma	Leiomyosarcoma|Rectal_Sarcoma	Rectal Leiomyosarcoma|Leiomyosarcoma of Rectum|Leiomyosarcoma of the Rectum
C5550	Rectal_Kaposi_s_Sarcoma	Kaposi_s_Sarcoma|Rectal_Sarcoma	Rectal Kaposi's Sarcoma|Kaposi's Sarcoma of Rectum|Kaposi's Sarcoma of the Rectum
C5551	Rectal_Lipoma	Benign_Rectal_Neoplasm|Colorectal_Lipoma	Rectal Lipoma|Lipoma of Rectum|Lipoma of the Rectum
C5552	Rectal_Leiomyoma	Benign_Rectal_Neoplasm|Colorectal_Leiomyoma	Rectal Leiomyoma|Leiomyoma of Rectum|Leiomyoma of the Rectum
C5553	Rectal_Lymphoma	Gastrointestinal_Lymphoma|Malignant_Rectal_Neoplasm	Rectal Lymphoma|Lymphoma of Rectum|Lymphoma of the Rectum|Primary Rectal Lymphoma
C5554	Rectal_Squamous_Cell_Carcinoma	Colorectal_Squamous_Cell_Carcinoma|Rectal_Carcinoma	Rectal Squamous Cell Carcinoma|Rectal Squamous Carcinoma|Squamous Carcinoma of Rectum|Squamous Carcinoma of the Rectum|Squamous Cell Carcinoma of Rectum|Squamous Cell Carcinoma of the Rectum
C5555	Cloacogenic_Carcinoma_of_the_Rectum	Rectal_Squamous_Cell_Carcinoma	Cloacogenic Carcinoma of the Rectum|Cloacogenic Carcinoma of Rectum|Rectal Cloacogenic Carcinoma|Rectal Transition Zone Carcinoma|Rectal Transitional Zone Carcinoma|Transition Zone Carcinoma of Rectum|Transition Zone Carcinoma of the Rectum|Transitional Zone Carcinoma of Rectum|Transitional Zone Carcinoma of the Rectum
C5556	Rectal_Sarcomatoid_Carcinoma	Rectal_Carcinoma|Sarcomatoid_Carcinoma	Rectal Sarcomatoid Carcinoma|Sarcomatoid Carcinoma of Rectum|Sarcomatoid Carcinoma of the Rectum
C5558	Ceruminous_Neoplasm	Apocrine_Neoplasm	Ceruminous Neoplasm|Ceruminous Tumor
C5559	Malignant_Eccrine_Neoplasm	Eccrine_Neoplasm|Malignant_Sweat_Gland_Neoplasm	Malignant Eccrine Neoplasm|Malignant Eccrine Neoplasm of Skin|Malignant Eccrine Neoplasm of the Skin|Malignant Eccrine Skin Neoplasm|Malignant Eccrine Skin Tumor|Malignant Eccrine Tumor|Malignant Eccrine Tumor of Skin|Malignant Eccrine Tumor of the Skin
C5560	Eccrine_Porocarcinoma	Eccrine_Adenocarcinoma	Eccrine Porocarcinoma|Malignant Eccrine Poroma
C5562	Skin_Appendage_Hamartoma	Hamartoma|Non-Neoplastic_Skin_Disorder	Skin Appendage Hamartoma|Hamartoma of Skin Appendage
C5563	Apocrine_Sweat_Gland_Hamartoma	Skin_Appendage_Hamartoma	Apocrine Sweat Gland Hamartoma|Hamartoma of Apocrine Sweat Gland|Hamartoma of the Apocrine Sweat Gland
C5564	Eccrine_Sweat_Gland_Hamartoma	Skin_Appendage_Hamartoma	Eccrine Sweat Gland Hamartoma|Hamartoma of Eccrine Sweat Gland|Hamartoma of the Eccrine Sweat Gland
C5565	Pilosebaceous_Hamartoma	Skin_Appendage_Hamartoma	Pilosebaceous Hamartoma
C5566	Cutaneous_Lipomatous_Neoplasm	Dermal_Neoplasm|Lipomatous_Neoplasm	Cutaneous Lipomatous Neoplasm|Cutaneous Lipomatous Tumor|Lipomatous Neoplasm of Skin|Lipomatous Neoplasm of the Skin|Lipomatous Skin Neoplasm|Lipomatous Skin Tumor|Lipomatous Tumor of Skin|Lipomatous Tumor of the Skin
C5567	Temporal_Lobe_Neoplasm	Cerebral_Neoplasm	Temporal Lobe Neoplasm|Neoplasm of Temporal Lobe|Neoplasm of the Temporal Lobe|Temporal Lobe Tumor|Tumor of Temporal Lobe|Tumor of the Temporal Lobe
C5568	Nodulo-Ulcerative_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma	Skin Nodulo-Ulcerative Basal Cell Carcinoma
C5569	Benign_Dermal_Schwannoma	Benign_Dermal_Neoplasm|Benign_Schwannoma|Cutaneous_Neural_Neoplasm|Peripheral_Nerve_Schwannoma	Benign Dermal Schwannoma|Benign Dermal Neurilemmoma|Benign Neurilemmoma of Skin|Benign Neurilemmoma of the Skin|Benign Schwannoma of Skin|Benign Schwannoma of the Skin|Benign Skin Neurilemmoma|Benign Skin Schwannoma
C5570	Congenital_Skin_Nevus	Non-Neoplastic_Nevus	Congenital Skin Nevus|Congenital Nevus of Skin|Congenital Nevus of the Skin
C5571	Adnexal_Adenocarcinoma	Retired_Concepts	Adnexal Adenocarcinoma|Adenocarcinoma of Adnexa|Adenocarcinoma of Skin Appendage|Adenocarcinoma of the Adnexa|Adenocarcinoma of the Skin Appendage|Skin Appendage Adenocarcinoma
C5572	Frontal_Lobe_Neoplasm	Cerebral_Neoplasm	Frontal Lobe Neoplasm|Frontal Lobe Tumor|Neoplasm of Frontal Lobe|Neoplasm of the Frontal Lobe|Tumor of Frontal Lobe|Tumor of the Frontal Lobe
C5573	Parietal_Lobe_Neoplasm	Cerebral_Neoplasm	Parietal Lobe Neoplasm|Neoplasm of Parietal Lobe|Neoplasm of the Parietal Lobe|Parietal Lobe Tumor|Tumor of Parietal Lobe|Tumor of the Parietal Lobe
C5574	Occipital_Lobe_Neoplasm	Cerebral_Neoplasm	Occipital Lobe Neoplasm|Neoplasm of Occipital Lobe|Neoplasm of the Occipital Lobe|Occipital Lobe Tumor|Tumor of Occipital Lobe|Tumor of the Occipital Lobe
C5575	Apocrine_Gland_Carcinoma	Retired_Concepts	Apocrine Gland Carcinoma|Carcinoma of Apocrine Gland|Carcinoma of the Apocrine Gland
C5576	Malignant_Fibrous_Histiocytoma_of_the_Skin	Cutaneous_Fibrohistiocytic_Neoplasm|Malignant_Fibrous_Histiocytoma	Malignant Fibrous Histiocytoma of the Skin|Malignant Fibrous Histiocytoma of Skin|Malignant Skin Fibrous Histiocytoma
C5577	Stage_I_Uveal_Melanoma	Uveal_Melanoma	Stage I Uveal Melanoma|Stage I Malignant Melanoma of Uvea|Stage I Malignant Melanoma of the Uvea|Stage I Melanoma of Uvea|Stage I Melanoma of the Uvea|Stage I Uveal Malignant Melanoma
C5578	Stage_II_Uveal_Melanoma	Uveal_Melanoma	Stage II Uveal Melanoma|Stage II Malignant Melanoma of Uvea|Stage II Malignant Melanoma of the Uvea|Stage II Melanoma of Uvea|Stage II Melanoma of the Uvea|Stage II Uveal Malignant Melanoma
C5579	Stage_III_Uveal_Melanoma	Uveal_Melanoma	Stage III Uveal Melanoma|Stage III Malignant Melanoma of Uvea|Stage III Malignant Melanoma of the Uvea|Stage III Melanoma of Uvea|Stage III Melanoma of the Uvea|Stage III Uveal Malignant Melanoma
C5580	Stage_IV_Uveal_Melanoma	Uveal_Melanoma	Stage IV Uveal Melanoma|Stage IV Malignant Melanoma of Uvea|Stage IV Malignant Melanoma of the Uvea|Stage IV Melanoma of Uvea|Stage IV Melanoma of the Uvea|Stage IV Uveal Malignant Melanoma
C5581	Stage_I_Skin_Cancer	Skin_Carcinoma	Stage I Skin Cancer|Carcinoma of Skin Stage I|Carcinoma of the Skin Stage I|Skin Cancer Stage I|Skin Carcinoma Stage I
C5582	Stage_II_Skin_Cancer	Skin_Carcinoma	Stage II Skin Cancer|Carcinoma of Skin Stage II|Carcinoma of the Skin Stage II|Skin Cancer Stage II|Skin Carcinoma Stage II
C5583	Stage_III_Skin_Cancer	Skin_Carcinoma	Stage III Skin Cancer|Carcinoma of Skin Stage III|Carcinoma of the Skin Stage III|Skin Cancer Stage III|Skin Carcinoma Stage III|Stage III Skin Carcinoma
C5584	Stage_IV_Skin_Caner	Skin_Carcinoma	Stage IV Skin Caner|Carcinoma of Skin Stage IV|Carcinoma of the Skin Stage IV|Skin Cancer Stage IV|Skin Carcinoma Stage IV|Stage IV Skin Carcinoma
C5585	Skin_Sarcoma	Malignant_Skin_Neoplasm|Soft_Tissue_Sarcoma	Skin Sarcoma|Cutaneous Sarcoma|Sarcoma of Skin|Sarcoma of the Skin
C5586	Middle_Cranial_Fossa_Meningioma	Supratentorial_Meningioma|Supratentorial_Neoplasm	Middle Cranial Fossa Meningioma|Meningioma of Middle Cranial Fossa|Meningioma of the Middle Cranial Fossa
C5587	Visual_Pathway_Meningioma	Intracranial_Meningioma|Visual_Pathway_Neoplasm	Visual Pathway Meningioma|Meningioma of Optic Tract|Meningioma of Visual Pathway|Meningioma of the Optic Tract|Meningioma of the Visual Pathway|Optic Tract Meningioma
C5588	Recurrent_Medulloblastoma	Medulloblastoma	Recurrent Medulloblastoma|Relapsed Medulloblastoma
C5589	Jugular_Foramen_Neoplasm	Neck_Neoplasm	Jugular Foramen Neoplasm|Jugular Foramen Neoplasms|Jugular Foramen Tumor|Jugular Foramen Tumors|Neoplasm of Jugular Foramen|Neoplasm of the Jugular Foramen|Tumor of Jugular Foramen|Tumor of the Jugular Foramen
C5590	Intraspinal_Cyst	Central_Nervous_System_Cyst	Intraspinal Cyst|Cyst of Spinal Canal and Spinal Cord|Cyst of the Spinal Canal and Spinal Cord|Intraspinal Cysts|Spinal Canal and Spinal Cord Cyst
C5591	Benign_Childhood_Central_Nervous_System_Neoplasm	Childhood_Central_Nervous_System_Neoplasm	Benign Childhood Central Nervous System Neoplasm|Benign Childhood CNS Neoplasm|Benign Childhood CNS Tumor|Benign Childhood Central Nervous System Tumor|Benign Childhood Neoplasm of CNS|Benign Childhood Neoplasm of Central Nervous System|Benign Childhood Neoplasm of the CNS|Benign Childhood Neoplasm of the Central Nervous System|Benign Childhood Tumor of CNS|Benign Childhood Tumor of Central Nervous System|Benign Childhood Tumor of the CNS|Benign Childhood Tumor of the Central Nervous System|Benign Pediatric CNS Neoplasm|Benign Pediatric CNS Tumor|Benign Pediatric Central Nervous System Neoplasm|Benign Pediatric Central Nervous System Tumor|Benign Pediatric Neoplasm of CNS|Benign Pediatric Neoplasm of Central Nervous System|Benign Pediatric Neoplasm of the CNS|Benign Pediatric Neoplasm of the Central Nervous System|Benign Pediatric Tumor of CNS|Benign Pediatric Tumor of Central Nervous System|Benign Pediatric Tumor of the CNS|Benign Pediatric Tumor of the Central Nervous System|Childhood Benign Central Nervous System Neoplasms
C5592	Chordoid_Glioma	Central_Nervous_System_Neuroepithelial_Neoplasm_of_Uncertain_Origin	Chordoid Glioma
C5593	Prostatic_Basal_Cell_Hyperplasia	Basal_Cell_Hyperplasia|Benign_Prostatic_Hyperplasia	Prostatic Basal Cell Hyperplasia|Basal Cell Hyperplasia of Prostate|Basal Cell Hyperplasia of the Prostate|Basal Cell Prostate Hyperplasia
C5594	Prostatic_Cribriform_Hyperplasia	Benign_Prostatic_Hyperplasia	Prostatic Cribriform Hyperplasia|Cribriform Hyperplasia of Prostate|Cribriform Hyperplasia of the Prostate|Cribriform Prostate Hyperplasia
C5595	Prostatic_Atypical_Adenomatous_Hyperplasia	Atypical_Glandular_Hyperplasia	Prostatic Atypical Adenomatous Hyperplasia|Atypical Adenomatous Hyperplasia of Prostate|Atypical Adenomatous Hyperplasia of the Prostate|Atypical Adenomatous Prostate Hyperplasia
C5596	Acinar_Prostate_Adenocarcinoma	Acinar_Cell_Carcinoma|Prostate_Adenocarcinoma	Acinar Prostate Adenocarcinoma|Acinar Adenocarcinoma of Prostate|Acinar Adenocarcinoma of the Prostate|Prostatic Acinar Adenocarcinoma
C5597	Undifferentiated_Prostate_Carcinoma	Prostate_Carcinoma|Undifferentiated_Carcinoma	Undifferentiated Prostate Carcinoma|Undifferentiated Carcinoma of Prostate|Undifferentiated Carcinoma of the Prostate|Undifferentiated Prostatic Carcinoma
C5598	Anal_Paget_s_Disease	Anal_Adenocarcinoma|Anal_Intraepithelial_Neoplasia|Extramammary_Paget_s_Disease	Paget's Disease of the Anus|Anal Paget's Disease|Paget's Disease of Anus	A slowly spreading, erythematous eczematoid plaque in the anal region.  Histologically, the basal part or whole thickness of the squamous epithelium is infiltrated by large cells with abundant pale cytoplasm and large nuclei.  Half of the cases are associated with an internal malignancy, most often a colorectal adenocarcinoma.  The other half of the cases, have a high local recurrence rate and they may become invasive.  -- 2003
C5599	Anal_Leiomyosarcoma	Anal_Sarcoma|Leiomyosarcoma	Anal Leiomyosarcoma|Leiomyosarcoma of Anus|Leiomyosarcoma of the Anus
C5600	Anal_Adenocarcinoma	Adenocarcinoma|Anal_Carcinoma	Anal Adenocarcinoma|Adenocarcinoma of Anus|Adenocarcinoma of the Anus	An adenocarcinoma arising in the anal canal epithelium, including the mucosal surface, the anal glands, and the lining of fistulous tracts.  The prognosis is related to the stage at diagnosis.  -- 2003
C5601	Anal_Lymphoma	Gastrointestinal_Lymphoma|Malignant_Anal_Neoplasm	Anal Lymphoma|Lymphoma of Anus|Lymphoma of the Anus|Primary Anal Lymphoma
C5602	Anal_Kaposi_s_Sarcoma	Anal_Sarcoma|Kaposi_s_Sarcoma	Anal Kaposi's Sarcoma|Kaposi's Sarcoma of Anus|Kaposi's Sarcoma of the Anus
C5603	Anal_Neuroendocrine_Neoplasm	Anal_Neoplasm|Gastrointestinal_Neuroendocrine_Neoplasm	Anal Neuroendocrine Neoplasm|Anal Neuroendocrine Tumor|Neuroendocrine Neoplasm of Anus|Neuroendocrine Neoplasm of the Anus|Neuroendocrine Tumor of Anus|Neuroendocrine Tumor of the Anus
C5604	Anal_Fibroepithelial_Polyp	Anal_Polyp|Fibroepithelial_Polyp	Anal Fibroepithelial Polyp|Fibroepithelial Polyp of Anus|Fibroepithelial Polyp of the Anus
C5606	Anal_Mucinous_Adenocarcinoma	Anal_Canal_Adenocarcinoma|Mucinous_Adenocarcinoma	Anal Mucinous Adenocarcinoma|Anal Colloid Adenocarcinoma|Anal Colloidal Adenocarcinoma|Colloid Adenocarcinoma of Anus|Colloid Adenocarcinoma of the Anus|Colloidal Adenocarcinoma of Anus|Colloidal Adenocarcinoma of the Anus|Mucinous Adenocarcinoma of Anus|Mucinous Adenocarcinoma of the Anus
C5607	Benign_Anal_Granular_Cell_Tumor	Benign_Anal_Neoplasm|Benign_Granular_Cell_Tumor	Benign Anal Granular Cell Tumor|Benign Anal Granular Cell Neoplasm|Benign Anal Myoblastoma|Benign Granular Cell Neoplasm of Anus|Benign Granular Cell Neoplasm of the Anus|Benign Granular Cell Tumor of Anus|Benign Granular Cell Tumor of the Anus|Benign Myoblastoma of Anus|Benign Myoblastoma of the Anus
C5608	Anal_Leiomyoma	Benign_Anal_Neoplasm|Leiomyoma	Anal Leiomyoma|Leiomyoma of Anus|Leiomyoma of the Anus
C5609	Anal_Glands_Adenocarcinoma	Anal_Extramucosal_Perianal_Adenocarcinoma	Anal Glands Adenocarcinoma|Adenocarcinoma of Anal Gland|Adenocarcinoma of the Anal Gland
C5610	Anal_Rhabdomyosarcoma	Anal_Sarcoma|Rhabdomyosarcoma	Anal Rhabdomyosarcoma|Rhabdomyosarcoma of Anus|Rhabdomyosarcoma of the Anus
C5611	Anal_Sarcoma	Malignant_Anal_Neoplasm|Soft_Tissue_Sarcoma	Anal Sarcoma|Sarcoma of Anus|Sarcoma of the Anus
C5612	Metastatic_Anal_Carcinoma	Stage_IV_Anal_Canal_Cancer	Metastatic Anal Carcinoma|Metastatic Anal Cancer|Metastatic Cancer from the Anus|Metastatic Carcinoma from the Anus|Secondary Cancer from the Anus|Secondary Carcinoma from the Anus
C5613	Benign_Eccrine_Spiradenoma	Benign_Eccrine_Neoplasm|Eccrine_Spiradenoma	Benign Eccrine Spiradenoma
C5614	Malignant_Cutaneous_Granular_Cell_Tumor	Cutaneous_Granular_Cell_Tumor|Malignant_Dermal_Neoplasm|Malignant_Granular_Cell_Tumor	Malignant Cutaneous Granular Cell Tumor|Malignant Granular Cell Neoplasm of Skin|Malignant Granular Cell Neoplasm of the Skin|Malignant Granular Cell Skin Neoplasm|Malignant Granular Cell Skin Tumor|Malignant Granular Cell Tumor of Skin|Malignant Granular Cell Tumor of the Skin
C5615	Cutaneous_Liposarcoma	Cutaneous_Lipomatous_Neoplasm|Liposarcoma|Skin_Sarcoma	Cutaneous Liposarcoma|Liposarcoma of Skin|Liposarcoma of the Skin|Skin Liposarcoma
C5616	Solid_Nodular_Basal_Cell_Skin_Carcinoma	Basal_Cell_Carcinoma	Skin Solid (Nodular) Basal Cell Carcinoma|Nodular Basal Cell Carcinoma|Nodular Basal Cell Carcinoma of Skin|Nodular Basal Cell Carcinoma of the Skin
C5617	Cutaneous_Granular_Cell_Tumor	Dermal_Neoplasm|Granular_Cell_Tumor	Cutaneous Granular Cell Tumor|Cutaneous Granular Cell Neoplasm|Granular Cell Neoplasm of Skin|Granular Cell Neoplasm of the Skin|Granular Cell Skin Tumor|Granular Cell Tumor of Skin|Granular Cell Tumor of the Skin|Skin Granular Cell Neoplasm
C5618	Rectal_Juvenile_Polyp	Colorectal_Juvenile_Polyp|Rectal_Polyp	Rectal Juvenile Polyp|Juvenile Polyp of Rectum|Juvenile Polyp of the Rectum
C5619	Rectal_Hyperplastic_Polyp	Colorectal_Hyperplastic_Polyp	Rectal Hyperplastic Polyp|Hyperplastic Polyp of Rectum|Hyperplastic Polyp of the Rectum
C5620	Rectal_Tubulovillous_Adenoma	Colorectal_Tubulovillous_Adenoma|Rectal_Adenoma	Rectal Tubulovillous Adenoma|Rectal Villotubular Adenoma|Tubulovillous Adenoma of Rectum|Tubulovillous Adenoma of the Rectum|Villotubular Adenoma of Rectum|Villotubular Adenoma of the Rectum
C5621	Rectal_Adenoma_with_Severe_Dysplasia	Colorectal_Adenoma_with_Severe_Dysplasia|Rectal_Adenoma	Rectal Adenoma with Severe Dysplasia|Adenoma of Rectum with Marked Dysplasia|Adenoma of the Rectum with Marked Dysplasia|Rectal Adenoma with Marked Dysplasia
C5622	Adult_Acute_Lymphoblastic_Leukemia_in_Complete_Remission	Adult_Acute_Lymphoblastic_Leukemia_in_Remission	Adult Acute Lymphoblastic Leukemia in Complete Remission|Adult Acute Lymphocytic Leukemia in Complete Remission|Adult Acute Lymphogenous Leukemia in Complete Remission|Adult Acute Lymphoid Leukemia in Complete Remission
C5623	Adult_Acute_Lymphoblastic_Leukemia_in_Partial_Remission	Adult_Acute_Lymphoblastic_Leukemia_in_Remission	Adult Acute Lymphoblastic Leukemia in Partial Remission|Adult Acute Lymphocytic Leukemia in Partial Remission|Adult Acute Lymphogenous Leukemia in Partial Remission|Adult Acute Lymphoid Leukemia in Partial Remission
C5624	V-SRC_Gene	AIDS-Related_Kaposi_s_Sarcoma|Gastric_Kaposi_s_Sarcoma	AIDS-Related Gastric Kaposi's Sarcoma|AIDS-Related Kaposi's Sarcoma of Stomach|AIDS-Related Kaposi's Sarcoma of the Stomach
C5627	Rectal_Rhabdomyosarcoma	Rectal_Sarcoma|Rhabdomyosarcoma	Rectal Rhabdomyosarcoma|Rhabdomyosarcoma of Rectum|Rhabdomyosarcoma of the Rectum
C5628	Metastatic_Skin_Cancer	Skin_Carcinoma	Metastatic Skin Cancer|Metastatic Cancer of Skin|Metastatic Skin Carcinoma	The spread of the cancer to and establishment in the skin.
C5629	Metastasis_to_Skin	Malignant_Skin_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Skin|Metastases to Skin|Metastasis to Skin|Metastatic Neoplasm to the Skin|Metastatic Tumor to the Skin|Skin Metastases|Skin Metastasis	The spread of the cancer to the skin.  This may be from a primary skin cancer, or from a cancer at a distant site.
C5630	Aleukemic_Monocytic_Leukemia_Cutis	Aleukemic_Leukemia_Cutis|Monocytic_Leukemia	Aleukemic Monocytic Leukemia Cutis
C5631	Aleukemic_Lymphoblastic_Leukemia_Cutis	Aleukemic_Leukemia_Cutis|Aleukemic_Lymphoblastic_Leukemia	Aleukemic Lymphoblastic Leukemia Cutis
C5632	Stage_IB_Hodgkin_s_Lymphoma	Stage_I_Hodgkin_s_Lymphoma	Stage IB Hodgkin's Lymphoma|Hodgkin's Disease Stage IB|Hodgkin's Lymphoma Stage IB|Stage IB Hodgkin Lymphoma|Stage IB Hodgkin's Disease
C5633	Stage_IVB_Hodgkin_s_Lymphoma	Stage_IV_Hodgkin_s_Lymphoma	Stage IVB Hodgkin's Lymphoma|Hodgkin's Disease Stage IVB|Hodgkin's Lymphoma Stage IVB|Stage IVB Hodgkin Lymphoma|Stage IVB Hodgkin's Disease
C5634	Stage_I_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma	Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma|Stage_I_Hodgkin_s_Lymphoma	Stage I Nodular Lymphocyte Predominant Hodgkin's Lymphoma|Stage I Hodgkin's Disease Nodular Lymphocyte Predominance Type|Stage I Hodgkin's Lymphoma Nodular Lymphocyte Predominance Type|Stage I Nodular Lymphocyte Predominant Hodgkin's Disease	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C5635	Small_Intestinal_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue|Small_Intestinal_Non-Hodgkin_s_Lymphoma	Small Intestinal Mucosa-Associated Lymphoid Tissue Lymphoma|MALT Lymphoma of Small Bowel|MALT Lymphoma of Small Intestine|MALT Lymphoma of the Small Bowel|MALT Lymphoma of the Small Intestine|MALToma of Small Bowel|MALToma of Small Intestine|MALToma of the Small Bowel|MALToma of the Small Intestine|Mucosa-Associated Lymphoid Tissue Lymphoma of Small Bowel|Mucosa-Associated Lymphoid Tissue Lymphoma of Small Intestine|Mucosa-Associated Lymphoid Tissue Lymphoma of the Small Bowel|Mucosa-Associated Lymphoid Tissue Lymphoma of the Small Intestine|Small Bowel MALT Lymphoma|Small Bowel MALToma|Small Bowel Mucosa-Associated Lymphoid Tissue Lymphoma|Small Intestine MALT Lymphoma|Small Intestine MALToma|Small Intestine Mucosa-Associated Lymphoid Tissue Lymphoma
C5636	Childhood_Anaplastic_Large_Cell_Lymphoma	Anaplastic_Large_Cell_Lymphoma|Childhood_Mature_T-and_NK-Cell_Lymphoma	Childhood Anaplastic Large Cell Lymphoma|Childhood CD30+ Anaplastic Large Cell Lymphoma|Childhood K-1+ Anaplastic Large Cell Lymphoma|Pediatric Anaplastic Large Cell Lymphoma|Pediatric CD30+ Anaplastic Large Cell Lymphoma|Pediatric K-1+ Anaplastic Large Cell Lymphoma
C5637	Childhood_Mature_T-and_NK-Cell_Lymphoma	Childhood_Non-Hodgkin_s_Lymphoma|Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Childhood Mature T- and NK-Cell Lymphoma|Childhood Peripheral T Cell Lymphoma|Pediatric Peripheral T Cell Lymphoma
C5638	Gastric_Hodgkin_s_Lymphoma	Gastric_Lymphoma|Gastrointestinal_Hodgkin_s_Lymphoma	Gastric Hodgkin's Lymphoma|Gastric Hodgkin Lymphoma|Gastric Hodgkin's Disease|Gastric Hodgkins Disease|Gastric Hodgkins Lymphoma|Hodgkin's Lymphoma of Stomach|Hodgkin's Lymphoma of the Stomach|Primary Gastric Hodgkin's Lymphoma
C5640	Childhood_Precursor_T-Lymphoblastic_Lymphoma_Leukemia	Precursor_T_Lymphoblastic_Leukemia_Lymphoma	Childhood Precursor T-Lymphoblastic Lymphoma/Leukemia
C5641	Occult_Lung_Carcinoma	Lung_Carcinoma	Occult Lung Carcinoma|Occult Carcinoma of Lung|Occult Carcinoma of the Lung	A lung carcinoma detectable by sputum cytology only.  The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed. (NCI05)
C5642	Stage_IA_Lung_Carcinoma	Stage_I_Lung_Cancer	Stage IA Lung Carcinoma|Stage IA Carcinoma of Lung|Stage IA Carcinoma of the Lung
C5643	Stage_IB_Lung_Carcinoma	Stage_I_Lung_Cancer	Stage IB Lung Carcinoma|Stage IB Carcinoma of Lung|Stage IB Carcinoma of the Lung
C5644	Stage_IIA_Lung_Carcinoma	Stage_II_Lung_Cancer	Stage IIA Lung Carcinoma|Stage IIA Carcinoma of Lung|Stage IIA Carcinoma of the Lung
C5645	Stage_IIB_Lung_Carcinoma	Stage_II_Lung_Cancer	Stage IIB Lung Carcinoma|Stage IIB Carcinoma of Lung|Stage IIB Carcinoma of the Lung
C5646	Stage_IIIA_Lung_Carcinoma	Stage_III_Lung_Cancer	Stage IIIA Lung Carcinoma|Stage IIIA Carcinoma of Lung|Stage IIIA Carcinoma of the Lung
C5647	Stage_IIIB_Lung_Carcinoma	Stage_III_Lung_Cancer	Stage IIIB Lung Carcinoma|Stage IIIB Carcinoma of Lung|Stage IIIB Carcinoma of the Lung
C5649	Acinar_Lung_Adenocarcinoma	Lung_Adenocarcinoma	Acinar Lung Adenocarcinoma|Acinar Adenocarcinoma of Lung|Acinar Adenocarcinoma of the Lung	A morphologic variant of lung adenocarcinoma characterized by the presence of acinar structures composed of columnar or cuboidal cells. (NCI05)
C5650	Papillary_Lung_Adenocarcinoma	Lung_Adenocarcinoma|Papillary_Adenocarcinoma	Papillary Lung Adenocarcinoma|Lung PAP-AD|Lung Papillary-Adenocarcinoma|Papillary Adenocarcinoma of Lung|Papillary Adenocarcinoma of the Lung	A morphologic variant of lung adenocarcinoma characterized by the presence of papillary structures.  (NCI05)
C5651	Solid_Lung_Carcinoma_with_Mucus_Formation	Lung_Adenocarcinoma	Solid Lung Adenocarcinoma with Mucin Production|Lung Solid Adenocarcinoma with Mucin|Pulmonary Solid Adenocarcinoma with Mucin|Solid Adenocarcinoma of Lung with Mucin|Solid Adenocarcinoma of the Lung with Mucin|Solid Carcinoma of Lung with Mucus Formation|Solid Carcinoma of the Lung with Mucus Formation|Solid Lung Carcinoma with Mucus Formation	A poorly differentiated morphologic variant of lung adenocarcinoma characterized by the presence of mucus formation. (NCI05)
C5652	Stage_IA_Non-Small_Cell_Lung_Carcinoma	Stage_IA_Lung_Carcinoma|Stage_I_Non-Small_Cell_Lung_Cancer	Stage IA Non-Small Cell Lung Carcinoma|Stage IA Non-Oat Cell Carcinoma of Lung|Stage IA Non-Oat Cell Carcinoma of the Lung|Stage IA Non-Oat Cell Lung Carcinoma|Stage IA Non-Small Cell Carcinoma of Lung|Stage IA Non-Small Cell Carcinoma of the Lung
C5653	Stage_IB_Non-Small_Cell_Lung_Carcinoma	Stage_IB_Lung_Carcinoma|Stage_I_Non-Small_Cell_Lung_Cancer	Stage IB Non-Small Cell Lung Carcinoma|Stage IB Non-Oat Cell Carcinoma of Lung|Stage IB Non-Oat Cell Carcinoma of the Lung|Stage IB Non-Oat Cell Lung Carcinoma|Stage IB Non-Small Cell Carcinoma of Lung|Stage IB Non-Small Cell Carcinoma of the Lung
C5654	Stage_IIB_Non-Small_Cell_Lung_Carcinoma	Stage_IIB_Lung_Carcinoma|Stage_II_Non-Small_Cell_Lung_Cancer	Stage IIB Non-Small Cell Lung Carcinoma|Stage IIB Non-Oat Cell Carcinoma of Lung|Stage IIB Non-Oat Cell Carcinoma of the Lung|Stage IIB Non-Oat Cell Lung Carcinoma|Stage IIB Non-Small Cell Carcinoma of Lung|Stage IIB Non-Small Cell Carcinoma of the Lung
C5655	Stage_IIA_Non-Small_Cell_Lung_Carcinoma	Stage_IIA_Lung_Carcinoma|Stage_II_Non-Small_Cell_Lung_Cancer	Stage IIA Non-Small Cell Lung Carcinoma|Stage IIA Non-Oat Cell Carcinoma of Lung|Stage IIA Non-Oat Cell Carcinoma of the Lung|Stage IIA Non-Oat Cell Lung Carcinoma|Stage IIA Non-Small Cell Carcinoma of Lung|Stage IIA Non-Small Cell Carcinoma of the Lung
C5656	Lung_Sclerosing_Hemangioma	Benign_Lung_Neoplasm	Lung Sclerosing Hemangioma|Lung Sclerosing Angioma|Pneumocytoma|Sclerosing Angioma of Lung|Sclerosing Angioma of the Lung|Sclerosing Hemangioma of Lung|Sclerosing Hemangioma of the Lung
C5657	Lung_Myolipoma	Benign_Lung_Neoplasm|Lung_Soft_Tissue_Neoplasm|Myolipoma	Lung Myolipoma|Myolipoma of Lung|Myolipoma of the Lung|Pulmonary Myolipoma
C5658	Lung_Fibroma	Benign_Lung_Neoplasm|Fibroma|Lung_Soft_Tissue_Neoplasm	Lung Fibroma|Fibroma of Lung|Fibroma of the Lung|Pulmonary Fibroma
C5659	Lung_Chondroid_Hamartoma	Retired_Concepts	Pulmonary Chondroid Hamartoma|Chondroid Hamartoma of Lung|Chondroid Hamartoma of the Lung|Lung Chondroid Hamartoma
C5660	Lung_Leiomyoma	Benign_Lung_Neoplasm|Leiomyoma|Lung_Soft_Tissue_Neoplasm	Lung Leiomyoma|Leiomyoma of Lung|Leiomyoma of the Lung|Pulmonary Leiomyoma
C5661	Endobronchial_Leiomyoma	Lung_Leiomyoma	Endobronchial Leiomyoma
C5662	Endobronchial_Hamartoma	Lung_Hamartoma	Endobronchial Hamartoma
C5663	Multiple_Chondromatous_Lung_Hamartoma	Lung_Hamartoma	Multiple Lung Hamartomas|Multiple Chondromatous Hamartoma of Lung|Multiple Chondromatous Hamartoma of the Lung|Multiple Chondromatous Lung Hamartoma
C5664	Bronchial_Mucus_Gland_Adenoma	Lung_Adenoma	Lung Mucus Gland Adenoma|Adenoma of Bronchial Mucus Gland|Adenoma of the Bronchial Mucus Gland|Bronchial Cystadenoma|Lung Polyadenoma
C5665	Atypical_Adenomatous_Lung_Hyperplasia	Atypical_Hyperplasia|Lung_Neoplasm|Pulmonary_Precancerous_Condition	Atypical Adenomatous Lung Hyperplasia|Atypical Adenomatous Hyperplasia of Lung|Atypical Adenomatous Hyperplasia of the Lung|Atypical Alveolar Hyperplasia|Bronchioloalveolar Cell Adenoma
C5666	Lung_Adenoid_Cystic_Carcinoma	Adenoid_Cystic_Carcinoma|Lung_Carcinoma	Lung Adenoid Cystic Carcinoma|Adenocystic Carcinoma of Lung|Adenocystic Carcinoma of the Lung|Adenoid Cystic Carcinoma of Lung|Adenoid Cystic Carcinoma of the Lung|Lung Adenocystic Carcinoma|Pulmonary Adenocystic Carcinoma|Pulmonary Adenoid Cystic Carcinoma	A rare usually indolent lung carcinoma characterized by a cribiform and tubular pattern and the presence of glandular epithelial cells.  Clinical symptoms include shortness of breath, cough, wheeze, hemopytsis and chest pain. (NCI05)
C5667	Lung_Leiomyosarcoma	Leiomyosarcoma|Lung_Sarcoma	Lung Leiomyosarcoma|Leiomyosarcoma of Lung|Leiomyosarcoma of the Lung|Pulmonary Leiomyosarcoma
C5668	Lung_Meningioma	Ectopic_Meningioma|Lung_Neoplasm	Lung Meningioma|Meningioma of Lung|Meningioma of the Lung|Pulmonary Meningioma
C5669	Pleuropulmonary_Blastoma	Blastoma|Malignant_Lung_and_Pleural_Neoplasm	Pleuropulmonary Blastoma|Pulmonary Blastoma of Childhood	A malignant neoplasm affecting the lungs and the pleura.  Pleuropulmonary blastoma is seen in children.  Microscopically, the tumor may show features of chondrosarcoma, leiomyosarcoma, rhabdomyosarcoma, liposarcoma, or undifferentiated sarcoma.  --2003
C5670	Lung_Neuroendocrine_Neoplasm	Malignant_Lung_Neoplasm|Neuroendocrine_Neoplasm	Lung Neuroendocrine Neoplasm|Lung Neuroendocrine Tumor|Neuroendocrine Neoplasm of Lung|Neuroendocrine Neoplasm of the Lung|Neuroendocrine Tumor of Lung|Neuroendocrine Tumor of the Lung|Pulmonary Neuroendocrine Neoplasm|Pulmonary Neuroendocrine Tumor
C5671	Lung_Hilum_Neoplasm	Lung_Neoplasm	Lung Hilum Neoplasm|Hilar Lung Neoplasm|Hilar Lung Tumor|Lung Hilum Tumor
C5672	Large_Cell_Neuroendocrine_Lung_Carcinoma	High_Grade_Lung_Neuroendocrine_Neoplasm|Large_Cell_Lung_Carcinoma|Large_Cell_Neuroendocrine_Carcinoma	Large Cell Lung Neuroendocrine Carcinoma|Large Cell Lung Carcinoma with Neuroendocrine Differentiation|Large Cell Neuroendocrine Carcinoma of Lung|Large Cell Neuroendocrine Carcinoma of the Lung|Pulmonary Large Cell Neuroendocrine Carcinoma
C5673	Colorectal_Adenoma	Adenomatous_Polyp|Colorectal_Neoplasm|Colorectal_Polyp|Gastrointestinal_Adenoma	Colorectal Adenoma|Adenoma of Large Bowel|Adenoma of Large Intestine|Adenoma of the Large Bowel|Adenoma of the Large Intestine|Adenomatous Polyp of Large Bowel|Adenomatous Polyp of the Large Bowel|Colorectal Adenomatous Polyp|Large Bowel Adenoma|Large Bowel Adenomatous Polyp|Large Intestine Adenoma
C5674	Colorectal_Serrated_Adenoma	Colorectal_Adenoma|Serrated_Adenoma	Colorectal Serrated Adenoma|Large Bowel Serrated Adenoma|Serrated Adenoma of Large Bowel|Serrated Adenoma of the Large Bowel
C5675	Colorectal_Tubulovillous_Adenoma	Colorectal_Adenoma|Tubulovillous_Adenoma	Colorectal Tubulovillous Adenoma|Large Bowel Tubulovillous Adenoma|Tubulovillous Adenoma of Large Bowel|Tubulovillous Adenoma of the Large Bowel
C5676	Colorectal_Villous_Adenoma	Colorectal_Adenoma|Villous_Adenoma	Colorectal Villous Adenoma|Large Bowel Villous Adenoma|Villous Adenoma of Large Bowel|Villous Adenoma of the Large Bowel
C5677	Colorectal_Leiomyoma	Benign_Colorectal_Neoplasm|Leiomyoma	Colorectal Leiomyoma|Large Bowel Leiomyoma|Large Intestine Leiomyoma|Leiomyoma of Large Bowel|Leiomyoma of Large Intestine|Leiomyoma of the Large Bowel|Leiomyoma of the Large Intestine
C5678	Colorectal_Lipoma	Benign_Colorectal_Neoplasm|Lipoma	Colorectal Lipoma|Large Bowel Lipoma|Large Intestine Lipoma|Lipoma of Large Bowel|Lipoma of Large Intestine|Lipoma of the Large Bowel|Lipoma of the Large Intestine
C5679	Colorectal_Polyp	Gastrointestinal_Polyp	Colorectal Polyp|Large Bowel Polyp|Large Intestine Polyp|Polyp of Large Bowel|Polyp of Large Intestine|Polyp of the Large Bowel|Polyp of the Large Intestine
C5680	Colorectal_Inflammatory_Polyp	Colorectal_Polyp	Colorectal Inflammatory Polyp|Inflammatory Polyp of Large Bowel|Inflammatory Polyp of the Large Bowel|Large Bowel Inflammatory Polyp
C5681	Colorectal_Juvenile_Polyp	Colorectal_Polyp|Juvenile_Polyp	Colorectal Juvenile Polyp|Juvenile Polyp of Large Bowel|Juvenile Polyp of the Large Bowel|Large Bowel Juvenile Polyp
C5682	Colorectal_Hyperplastic_Polyp	Colorectal_Polyp|Hyperplastic_Polyp	Colorectal Hyperplastic Polyp|Hyperplastic Large Bowel Polyp|Hyperplastic Polyp of Large Bowel|Hyperplastic Polyp of the Large Bowel
C5684	Lung_Non-Hodgkin_s_Lymphoma	Lung_Lymphoma|Non-Hodgkin_s_Lymphoma	Lung Non-Hodgkin's Lymphoma|Lung Non-Hodgkin Lymphoma|Primary Lung Non-Hodgkin's Lymphoma
C5685	Colorectal_Adenoma_with_Severe_Dysplasia	Colorectal_Adenoma	Colorectal Adenoma with Severe Dysplasia|Colorectal Adenoma with Marked Dysplasia
C5686	Peutz-Jeghers_Colon_Polyp	Retired_Concepts	Peutz-Jeghers Colon Polyp|Peutz Jeghers Colon Polyp|Peutz-Jeghers Polyp of Colon|Peutz-Jeghers Polyp of the Colon
C5687	Esophageal_Lymphoma	Gastrointestinal_Lymphoma|Malignant_Esophageal_Neoplasm	Esophageal Lymphoma|Esophagus Lymphoma|Lymphoma of Esophagus|Lymphoma of the Esophagus|Primary Esophageal Lymphoma	Primary esophageal lymphomas are infrequent.  Esophageal involvement is usually secondary from the mediastinum, lymph nodes, or a primary gastric location.  Patients are usually males, middle aged or elderly.  Dysphagia may be the presenting symptom.  Large cell lymphomas and B-cell lymphomas of the mucosa-associated lymphoid tissue are the most commonly seen morphologic variants.  (WHO, 2000) -- 2003
C5688	Esophageal_Non-Hodgkin_s_Lymphoma	Esophageal_Lymphoma|Gastrointestinal_Non-Hodgkin_s_Lymphoma	Esophageal Non-Hodgkin's Lymphoma|Esophagus Non-Hodgkin Lymphoma|Non-Hodgkin's Esophagus Lymphoma|Non-Hodgkin's Lymphoma of Esophagus|Non-Hodgkin's Lymphoma of the Esophagus|Primary Esophageal Non-Hodgkin's Lymphoma
C5689	Esophageal_Hodgkin_s_Lymphoma	Esophageal_Lymphoma|Gastrointestinal_Hodgkin_s_Lymphoma	Esophageal Hodgkin's Lymphoma|Esophageal Hodgkin's Disease|Esophagus Hodgkin Lymphoma|Esophagus Hodgkin's Disease|Esophagus Hodgkin's Lymphoma|Hodgkin's Disease of Esophagus|Hodgkin's Disease of the Esophagus|Hodgkin's Lymphoma of Esophagus|Hodgkin's Lymphoma of the Esophagus|Primary Esophageal Hodgkin's Lymphoma
C5691	Stage_IIA_Esophageal_Cancer	Stage_II_Esophageal_Cancer	Stage IIA Esophageal Cancer|Esophageal Cancer Stage IIA|Stage IIA Carcinoma of Esophagus|Stage IIA Carcinoma of the Esophagus|Stage IIA Esophageal Carcinoma|Stage IIA Esophagus Carcinoma
C5692	Stage_IIB_Esophageal_Cancer	Stage_II_Esophageal_Cancer	Stage IIB Esophageal Cancer|Esophageal Cancer Stage IIB|Stage IIB Carcinoma of Esophagus|Stage IIB Carcinoma of the Esophagus|Stage IIB Esophageal Carcinoma|Stage IIB Esophagus Carcinoma
C5693	Stage_IVB_Esophageal_Cancer	Stage_IV_Esophageal_Cancer	Stage IVB Esophageal Cancer|Esophageal Cancer Stage IVB|Stage IVB Carcinoma of Esophagus|Stage IVB Carcinoma of the Esophagus|Stage IVB Esophageal Carcinoma|Stage IVB Esophagus Carcinoma
C5694	Stage_IVA_Esophageal_Cancer	Stage_IV_Esophageal_Cancer	Stage IVA Esophageal Cancer|Esophageal Cancer Stage IVA|Stage IVA Carcinoma of Esophagus|Stage IVA Carcinoma of the Esophagus|Stage IVA Esophageal Carcinoma|Stage IVA Esophagus Carcinoma
C5695	Intestinal_Neuroendocrine_Neoplasm	Gastrointestinal_Neuroendocrine_Neoplasm|Intestinal_Neoplasm	Intestinal Neuroendocrine Neoplasm|Intestinal Neuroendocrine Tumor|Neuroendocrine Neoplasm of Intestine|Neuroendocrine Neoplasm of the Intestine|Neuroendocrine Tumor of Intestine|Neuroendocrine Tumor of the Intestine
C5696	Gastric_Neuroendocrine_Neoplasm	Gastric_Neoplasm|Gastrointestinal_Neuroendocrine_Neoplasm	Gastric Neuroendocrine Neoplasm|Gastric Neuroendocrine Tumor|Neuroendocrine Neoplasm of Stomach|Neuroendocrine Neoplasm of the Stomach|Neuroendocrine Tumor of Stomach|Neuroendocrine Tumor of the Stomach|Stomach Neuroendocrine Neoplasm|Stomach Neuroendocrine Tumor	Most neuroendocrine tumors of the stomach are well differentiated, nonfunctioning enterochromaffin-like cell carcinoids arising from the oxyntic mucosa in the corpus or fundus.  (WHO, 2000) -- 2003
C5697	Colon_Neuroendocrine_Neoplasm	Colon_Neoplasm|Intestinal_Neuroendocrine_Neoplasm	Colon Neuroendocrine Neoplasm|Colon Neuroendocrine Tumor|Colonic Neuroendocrine Neoplasm|Colonic Neuroendocrine Tumor|Neuroendocrine Neoplasm of Colon|Neuroendocrine Neoplasm of the Colon|Neuroendocrine Tumor of Colon|Neuroendocrine Tumor of the Colon
C5698	Rectal_Neuroendocrine_Neoplasm	Intestinal_Neuroendocrine_Neoplasm|Rectal_Neoplasm	Rectal Neuroendocrine Neoplasm|Neuroendocrine Neoplasm of Rectum|Neuroendocrine Neoplasm of the Rectum|Neuroendocrine Tumor of Rectum|Neuroendocrine Tumor of the Rectum|Rectal Neuroendocrine Tumor
C5699	Giant_Fibrovascular_Esophageal_Polyp	Esophageal_Polyp	Giant Fibrovascular Esophageal Polyp|Giant Fibrovascular Esophagus Polyp|Giant Fibrovascular Polyp of Esophagus|Giant Fibrovascular Polyp of the Esophagus
C5700	Esophageal_Granular_Cell_Tumor	Esophageal_Neoplasm|Granular_Cell_Tumor	Esophageal Granular Cell Tumor|Esophageal Granular Cell Myoblastoma|Esophageal Granular Cell Neoplasm|Granular Cell Esophageal Tumor|Granular Cell Esophagus Myoblastoma|Granular Cell Esophagus Neoplasm|Granular Cell Esophagus Tumor|Granular Cell Myoblastoma of Esophagus|Granular Cell Myoblastoma of the Esophagus|Granular Cell Neoplasm of Esophagus|Granular Cell Neoplasm of the Esophagus|Granular Cell Tumor of Esophagus|Granular Cell Tumor of the Esophagus	A tumor that usually presents with small nodules or small sessile polyps, predominantly in the distal esophagus.  Histologically, they are composed of sheets of oval to polygonal cells with a small central nucleus and abundant granular cytoplasm.  This is usually a benign tumor.  (WHO, 2000) -- 2003
C5701	Esophageal_Lipoma	Benign_Esophageal_Neoplasm|Lipoma	Esophageal Lipoma|Lipoma of Esophagus|Lipoma of the Esophagus
C5702	Esophageal_Fibroma	Benign_Esophageal_Neoplasm|Fibroma	Esophageal Fibroma|Fibroma of Esophagus|Fibroma of the Esophagus
C5703	Benign_Esophageal_Schwannoma	Benign_Esophageal_Neoplasm|Benign_Schwannoma|Peripheral_Nerve_Schwannoma	Benign Esophageal Schwannoma|Benign Esophageal Neurilemmoma|Benign Esophagus Neurilemmoma|Benign Esophagus Schwannoma|Benign Neurilemmoma of Esophagus|Benign Neurilemmoma of the Esophagus|Benign Schwannoma of Esophagus|Benign Schwannoma of the Esophagus
C5704	Esophageal_Neurofibroma	Benign_Esophageal_Neoplasm|Neurofibroma	Esophageal Neurofibroma|Esophagus Neurofibroma|Neurofibroma of Esophagus|Neurofibroma of the Esophagus
C5705	Esophageal_Liposarcoma	Esophageal_Sarcoma|Liposarcoma	Esophageal Liposarcoma|Esophagus Liposarcoma|Liposarcoma of Esophagus|Liposarcoma of the Esophagus
C5706	Esophageal_Kaposi_s_Sarcoma	Esophageal_Sarcoma|Kaposi_s_Sarcoma	Esophageal Kaposi's Sarcoma|Esophagus Kaposi's Sarcoma|Kaposi's Sarcoma of Esophagus|Kaposi's Sarcoma of the Esophagus
C5707	Esophageal_Melanoma	Gastrointestinal_Melanoma|Malignant_Esophageal_Neoplasm|Non-Cutaneous_Melanoma	Esophageal Melanoma|Esophagus Melanoma|Melanoma of Esophagus|Melanoma of the Esophagus	A melanoma affecting the esophageal wall.  Melanoma in the esophagus is more commonly metastatic than primary.  Primary melanomas of the esophagus are polypoid and clinically aggressive.  (WHO, 2000) -- 2003
C5708	Stage_III_Childhood_Hepatocellular_Carcinoma	Childhood_Hepatocellular_Carcinoma|Stage_III_Hepatocellular_Carcinoma	Stage III Childhood Hepatocellular Carcinoma|Stage III Childhood Hepatoma|Stage III Childhood Liver Cell Carcinoma|Stage III Pediatric Hepatocellular Carcinoma|Stage III Pediatric Hepatoma|Stage III Pediatric Liver Cell Carcinoma
C5709	Stage_II_Childhood_Hepatocellular_Carcinoma	Childhood_Hepatocellular_Carcinoma|Stage_II_Hepatocellular_Carcinoma	Stage II Childhood Hepatocellular Carcinoma|Stage II Childhood Hepatoma|Stage II Childhood Liver Cell Carcinoma|Stage II Pediatric Hepatocellular Carcinoma|Stage II Pediatric Hepatoma|Stage II Pediatric Liver Cell Carcinoma
C5710	Stage_I_Childhood_Hepatocellular_Carcinoma	Childhood_Hepatocellular_Carcinoma|Stage_I_Hepatocellular_Carcinoma	Stage I Childhood Hepatocellular Carcinoma|Stage I Childhood Hepatoma|Stage I Childhood Liver Cell Carcinoma|Stage I Pediatric Hepatocellular Carcinoma|Stage I Pediatric Hepatoma|Stage I Pediatric Liver Cell Carcinoma
C5711	Stage_IV_Pancreatic_Cancer	Pancreatic_Carcinoma	Stage IV Pancreatic Cancer|Metastatic Pancreatic Carcinoma|Pancreatic Cancer Stage IV|Stage IV Carcinoma of Pancreas|Stage IV Carcinoma of the Pancreas|Stage IV Pancreatic Carcinoma|stage IV pancreatic cancer	Cancer of the pancreas in which the cancer has spread to organs near the pancreas (stage IVA) or to organs far away from the pancreas (stage IVB).
C5712	Pancreatic_Serous_Cystadenoma	Pancreatic_Cystadenoma|Pancreatic_Serous_Cystic_Neoplasm|Serous_Cystadenoma	Pancreatic Serous Cystadenoma|Serous Cystadenoma of Pancreas|Serous Cystadenoma of the Pancreas
C5713	Pancreatic_Mucinous_Cystadenocarcinoma	Pancreatic_Cystadenocarcinoma|Pancreatic_Mucinous_Cystic_Neoplasm	Pancreatic Mucinous Cystadenocarcinoma|Colloid Cystadencarcinoma of Pancreas|Colloid Cystadencarcinoma of the Pancreas|Colloidal Cystadencarcinoma of Pancreas|Colloidal Cystadencarcinoma of the Pancreas|Mucinous Cystadencarcinoma of Pancreas|Mucinous Cystadencarcinoma of the Pancreas|Pancreatic Colloid Cystadencarcinoma|Pancreatic Colloidal Cystadencarcinoma
C5714	Pancreatic_Lymphoma	Gastrointestinal_Lymphoma|Malignant_Pancreatic_Neoplasm	Pancreatic Lymphoma|Lymphoma of Pancreas|Lymphoma of the Pancreas
C5715	Pancreatic_Sarcoma	Malignant_Pancreatic_Neoplasm|Soft_Tissue_Sarcoma	Pancreatic Sarcoma|Sarcoma of Pancreas|Sarcoma of the Pancreas
C5716	Borderline_Exocrine_Pancreatic_Neoplasm	Neoplasm_of_Uncertain_Malignant_Potential|Pancreatic_Precancerous_Condition	Borderline Exocrine Pancreatic Neoplasm|Borderline Exocrine Pancreatic Tumor|Borderline Neoplasm of Exocrine Pancreas|Borderline Neoplasm of the Exocrine Pancreas|Borderline Tumor of Exocrine Pancreas|Borderline Tumor of the Exocrine Pancreas|Exocrine Pancreatic Neoplasm of Uncertain Malignant Potential|Exocrine Pancreatic Tumor of Uncertain Malignant Potential|Neoplasm of Uncertain Malignant Potential of Exocrine Pancreas|Neoplasm of Uncertain Malignant Potential of the Exocrine Pancreas|Tumor of Uncertain Malignant Potential of Exocrine Pancreas|Tumor of Uncertain Malignant Potential of the Exocrine Pancreas
C5717	Pancreatic_Mucinous_Ductal_Ectasia	Non-Neoplastic_Gastrointestinal_Disorder|Pancreatic_Disorder	Pancreatic Mucinous Ductal Ectasia
C5718	Pancreatic_Mucinous_Cystadenoma	Pancreatic_Cystadenoma|Pancreatic_Mucinous_Cystic_Neoplasm	Pancreatic Mucinous Cystadenoma|Colloid Cystadenoma of Pancreas|Colloid Cystadenoma of the Pancreas|Colloidal Cystadenoma of Pancreas|Colloidal Cystadenoma of the Pancreas|Mucinous Cystadenoma of Pancreas|Mucinous Cystadenoma of the Pancreas|Pancreatic Colloid Cystadenoma|Pancreatic Colloidal Cystadenoma
C5719	Pancreatic_Intraductal_Papillary-Mucinous_Neoplasm_with_Moderate_Dysplasia	Borderline_Exocrine_Pancreatic_Neoplasm|Pancreatic_Intraductal_Papillary-Mucinous_Neoplasm	Pancreatic Borderline Intraductal Papillary-Mucinous Neoplasm|Intraductal Papillary-Mucinous Neoplasm of Pancreas with Moderate Dysplasia|Intraductal Papillary-Mucinous Neoplasm of the Pancreas with Moderate Dysplasia|Intraductal Papillary-Mucinous Tumor of Pancreas with Moderate Dysplasia|Intraductal Papillary-Mucinous Tumor of the Pancreas with Moderate Dysplasia|Pancreatic Intraductal Papillary-Mucinous Neoplasm with Moderate Dysplasia|Pancreatic Intraductal Papillary-Mucinous Tumor with Moderate Dysplasia|Pancreatic Low Grade Malignant Intraductal Papillary-Mucinous Neoplasm
C5720	Pancreatic_Signet_Ring_Cell_Carcinoma	Pancreatic_Ductal_Adenocarcinoma|Signet_Ring_Cell_Carcinoma	Pancreatic Signet Ring Cell Carcinoma|Signet Ring Cell Carcinoma of Pancreas|Signet Ring Cell Carcinoma of the Pancreas
C5721	Pancreatic_Adenosquamous_Carcinoma	Adenosquamous_Carcinoma|Pancreatic_Ductal_Adenocarcinoma	Pancreatic Adenosquamous Carcinoma|Adenosquamous Carcinoma of Pancreas|Adenosquamous Carcinoma of the Pancreas
C5722	Undifferentiated_Pancreatic_Carcinoma	Pancreatic_Ductal_Adenocarcinoma|Undifferentiated_Carcinoma	Undifferentiated Pancreatic Carcinoma|Undifferentiated Carcinoma of Pancreas|Undifferentiated Carcinoma of the Pancreas
C5723	Pancreatic_Osteoclast-Like_Giant_Cell_Carcinoma	Pancreatic_Ductal_Adenocarcinoma	Pancreatic Osteoclast-Like Giant Cell Carcinoma|Osteoclast-like Giant Cell Neoplasm of Pancreas|Osteoclast-like Giant Cell Neoplasm of the Pancreas
C5724	Pancreatic_Serous_Cystadenocarcinoma	Pancreatic_Cystadenocarcinoma|Pancreatic_Serous_Cystic_Neoplasm|Serous_Cystadenocarcinoma	Pancreatic Serous Cystadenocarcinoma|Serous Cystadenocarcinoma of Pancreas|Serous Cystadenocarcinoma of the Pancreas
C5725	Pancreatic_Intraductal_Papillary-Mucinous_Carcinoma	Pancreatic_Adenocarcinoma|Pancreatic_Intraductal_Papillary-Mucinous_Neoplasm	Pancreatic Intraductal Papillary-Mucinous Carcinoma|Intraductal Papillary-Colloid Carcinoma of Pancreas|Intraductal Papillary-Colloid Carcinoma of the Pancreas|Intraductal Papillary-Colloidal Carcinoma of Pancreas|Intraductal Papillary-Colloidal Carcinoma of the Pancreas|Intraductal Papillary-Mucinous Carcinoma of Pancreas|Intraductal Papillary-Mucinous Carcinoma of the Pancreas|Pancreatic Intraductal Papillary-Colloid Carcinoma|Pancreatic Intraductal Papillary-Colloidal Carcinoma
C5726	Pancreatic_Invasive_Papillary-Mucinous_Carcinoma	Pancreatic_Intraductal_Papillary-Mucinous_Carcinoma	Pancreatic Invasive Intraductal Papillary-Mucinous Carcinoma
C5727	Pancreatic_Acinar_Cell_Cystadenocarcinoma	Pancreatic_Acinar_Cell_Carcinoma|Pancreatic_Cystadenocarcinoma	Pancreatic Acinar Cell Cystadenocarcinoma|Acinar Cell Cystadenocarcinoma|Acinar Cell Cystadenocarcinoma of Pancreas|Acinar Cell Cystadenocarcinoma of the Pancreas
C5728	Solid_Pseudopapillary_Carcinoma_of_the_Pancreas	Pancreatic_Carcinoma	Solid Pseudopapillary Carcinoma of the Pancreas|Pancreatic Solid Pseudopapillary Carcinoma|Solid Pseudopapillary Carcinoma of Pancreas
C5729	Stage_0_Pancreatic_Cancer	Grade_III_Glandular_Intraepithelial_Neoplasia|Pancreatic_Carcinoma|Pancreatic_Intraepithelial_Neoplasia	Stage 0 Pancreatic Cancer|Grade 3 Pancreatic Intraepithelial Neoplasia|Grade III Pancreatic Intraepithelial Neoplasia|Pancreatic Cancer Stage 0|Pancreatic Carcinoma in Situ|Severe Duct Dysplasia of Pancreas|Severe Duct Dysplasia of the Pancreas|Severe Pancreatic Duct Dysplasia|Stage 0 Carcinoma of Pancreas|Stage 0 Carcinoma of the Pancreas|Stage 0 Pancreatic Carcinoma	Stage 0: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C5730	Stage_IVA_Pancreatic_Cancer	Stage_IV_Pancreatic_Cancer	Stage IVA Pancreatic Cancer|Stage IVA Carcinoma of Pancreas|Stage IVA Carcinoma of the Pancreas|Stage IVA Pancreatic Carcinoma|stage IVA pancreatic cancer	Cancer has spread to organs that are near the pancreas (such as the stomach, spleen, or colon) but has not spread to distant organs (such as the liver or lungs).
C5731	Duodenal_G-Cell_Gastrin_Producing_Neoplasm	Small_Intestinal_G-Cell_Gastrin_Producing_Neoplasm	Duodenal Gastrin Producing Tumor|Duodenal G-Cell Gastrin Producing Tumor|Duodenal Gastrin Producing Neoplasm|Duodenal Gastrin Secreting Neoplasm|Duodenal Gastrin Secreting Tumor|Duodenal Gastrinoma|Gastrin Producing Neoplasm of Duodenum|Gastrin Producing Neoplasm of the Duodenum|Gastrin Producing Tumor of Duodenum|Gastrin Producing Tumor of the Duodenum|Gastrin Secreting Neoplasm of Duodenum|Gastrin Secreting Neoplasm of the Duodenum|Gastrin Secreting Tumor of Duodenum|Gastrin Secreting Tumor of the Duodenum|Gastrinoma of Duodenum|Gastrinoma of the Duodenum
C5734	Gallbladder_Lymphoma	Gastrointestinal_Lymphoma|Malignant_Gallbladder_Neoplasm	Gallbladder Lymphoma|Lymphoma of Gallbladder|Lymphoma of the Gallbladder|Primary Gallbladder Lymphoma
C5735	Gallbladder_Melanoma	Gastrointestinal_Melanoma|Malignant_Gallbladder_Neoplasm	Gallbladder Melanoma|Gallbladder Malignant Melanoma|Malignant Melanoma of Gallbladder|Malignant Melanoma of the Gallbladder|Melanoma of Gallbladder|Melanoma of the Gallbladder
C5736	Gallbladder_Sarcoma	Malignant_Gallbladder_Neoplasm|Soft_Tissue_Sarcoma	Gallbladder Sarcoma|Malignant Gallbladder Mesenchymal Neoplasm|Malignant Gallbladder Mesenchymal Tumor|Malignant Mesenchymal Neoplasm of Gallbladder|Malignant Mesenchymal Neoplasm of the Gallbladder|Malignant Mesenchymal Tumor of Gallbladder|Malignant Mesenchymal Tumor of the Gallbladder|Sarcoma of Gallbladder|Sarcoma of the Gallbladder
C5737	Stage_I_Gallbladder_Cancer	Gallbladder_Carcinoma	Stage I Gallbladder Cancer|Gallbladder Cancer Stage I|Gallbladder Carcinoma Stage I|Stage I Carcinoma of Gallbladder|Stage I Carcinoma of the Gallbladder|Stage I Gallbladder Carcinoma	Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0). T1: Tumor invades lamina propria or muscle layer.  T1a: Tumor invades lamina propria.  T1b: Tumor invades muscle layer.  N0: No regional metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C5738	Stage_II_Gallbladder_Cancer	Gallbladder_Carcinoma	Stage II Gallbladder Cancer|Gallbladder Cancer Stage II|Gallbladder Carcinoma Stage II|Stage II Carcinoma of Gallbladder|Stage II Carcinoma of the Gallbladder|Stage II Gallbladder Carcinoma	Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N0, M0); (T2, N0, M0); (T3, N0, M0).  T2: Tumor perforates the serosa (visceral peritoneum) and/or directly invades the liver and/or one other adjacent organ or structure, such as the stomach, duodenum, colon, or pancreas, omentum or extrahepatic bile ducts. (AJCC 6th ed.) - 2003
C5739	Stage_III_Gallbladder_Cancer	Gallbladder_Carcinoma	Stage III Gallbladder Cancer|Gallbladder Cancer Stage III|Gallbladder Carcinoma Stage III|Stage III Carcinoma of Gallbladder|Stage III Carcinoma of the Gallbladder|Stage III Gallbladder Carcinoma	Stage III includes: (T4, Any N, M0).  T4: Tumor invades main portal vein or hepatic artery or invades multiple extrahepatic organs or structures. (AJCC 6th ed.) - 2003
C5740	Stage_IV_Gallbladder_Cancer	Gallbladder_Carcinoma	Stage IV Gallbladder Cancer|Gallbladder Cancer Stage IV|Gallbladder Carcinoma Stage IV|Stage IV Carcinoma of Gallbladder|Stage IV Carcinoma of the Gallbladder|Stage IV Gallbladder Carcinoma	Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.) - 2003
C5741	Stage_IVA_Gallbladder_Cancer	Stage_IV_Gallbladder_Cancer	Stage IVA Gallbladder Cancer|Gallbladder Cancer Stage IVA|Gallbladder Carcinoma Stage IVA|Stage IVA Carcinoma of Gallbladder|Stage IVA Carcinoma of the Gallbladder|Stage IVA Gallbladder Carcinoma
C5742	Stage_IVB_Gallbladder_Cancer	Stage_IV_Gallbladder_Cancer	Stage IVB Gallbladder Cancer|Gallbladder Cancer Stage IVB|Gallbladder Carcinoma Stage IVB|Stage IVB Carcinoma of Gallbladder|Stage IVB Carcinoma of the Gallbladder|Stage IVB Gallbladder Carcinoma
C5743	Gallbladder_Papillary_Carcinoma	Gallbladder_Adenocarcinoma|Papillary_Adenocarcinoma	Gallbladder Papillary Adenocarcinoma|Papillary Carcinoma of Gallbladder|Papillary Carcinoma of the Gallbladder
C5744	Gallbladder_Mucinous_Carcinoma	Gallbladder_Adenocarcinoma|Mucinous_Adenocarcinoma	Gallbladder Mucinous Adenocarcinoma|Colloid Carcinoma of Gallbladder|Colloid Carcinoma of the Gallbladder|Colloidal Carcinoma of Gallbladder|Colloidal Carcinoma of the Gallbladder|Gallbladder Colloid Carcinoma|Gallbladder Colloidal Carcinoma|Mucinous Carcinoma of Gallbladder|Mucinous Carcinoma of the Gallbladder
C5745	Gallbladder_Signet_Ring_Cell_Carcinoma	Gallbladder_Adenocarcinoma|Signet_Ring_Cell_Carcinoma	Gallbladder Signet Ring Cell Carcinoma|Signet Ring Cell Carcinoma of Gallbladder|Signet Ring Cell Carcinoma of the Gallbladder
C5746	Gallbladder_Neurofibroma	Benign_Non-Epithelial_Gallbladder_Neoplasm|Neurofibroma	Gallbladder Neurofibroma|Neurofibroma of Gallbladder|Neurofibroma of the Gallbladder
C5747	Gallbladder_Leiomyoma	Benign_Non-Epithelial_Gallbladder_Neoplasm|Leiomyoma	Gallbladder Leiomyoma|Leiomyoma of Gallbladder|Leiomyoma of the Gallbladder
C5749	Benign_Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm	Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm	Benign Non-Epithelial Hepatic and Intrahepatic Bile Duct Neoplasm|Benign Non-Epithelial Hepatic Neoplasm|Benign Non-Epithelial Liver Neoplasm|Benign Non-Epithelial Liver and Intrahepatic Bile Duct Neoplasm
C5750	Hepatic_Lipoma	Benign_Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Hepatic_Disorder|Lipoma	Hepatic Lipoma|Lipoma of Liver|Lipoma of the Liver|Liver Lipoma
C5751	Hepatic_Mesenchymal_Hamartoma	Benign_Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Childhood_Hepatic_Neoplasm|Mesenchymal_Hamartoma	Hepatic Mesenchymal Hamartoma|Liver Mesenchymal Hamartoma|Mesenchymal Hamartoma of Liver|Mesenchymal Hamartoma of the Liver
C5752	Hepatic_Fibroma	Benign_Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Fibroma|Hepatic_Disorder	Hepatic Fibroma|Fibroma of Liver|Fibroma of the Liver|Liver Fibroma
C5753	Hepatic_Leiomyoma	Benign_Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Hepatic_Disorder|Leiomyoma	Hepatic Leiomyoma|Leiomyoma of Liver|Leiomyoma of the Liver|Liver Leiomyoma
C5754	Clear_Cell_Hepatocellular_Carcinoma	Clear_Cell_Adenocarcinoma|Hepatocellular_Carcinoma	Clear Cell Hepatocellular Carcinoma|Clear Cell Carcinoma of Liver Cells|Clear Cell Carcinoma of the Liver Cells|Hepatocellular Clear Cell Carcinoma|Liver Cell Clear Cell Carcinoma	A morphologic variant of hepatocellular carcinoma characterized by the presence of clear cells.
C5756	Hepatic_Leiomyosarcoma	Hepatic_Sarcoma|Leiomyosarcoma	Hepatic Leiomyosarcoma|Leiomyosarcoma of Liver|Leiomyosarcoma of the Liver|Liver Leiomyosarcoma
C5758	Stage_I_Hepatocellular_Carcinoma	Hepatocellular_Carcinoma|Stage_I_Liver_Cancer	Stage I Hepatocellular Carcinoma|Hepatocellular Cancer Stage I|Liver Cell Cancer Stage I|Stage I Hepatocellular Cancer|Stage I Liver Cell Cancer|Stage I Liver Cell Carcinoma
C5759	Stage_II_Hepatocellular_Carcinoma	Hepatocellular_Carcinoma|Stage_II_Liver_Cancer	Stage II Hepatocellular Carcinoma|Hepatocullular Cancer Stage II|Liver Cell Cancer Stage II|Stage II Hepatocellular Cancer|Stage II Liver Cell Cancer|Stage II Liver Cell Carcinoma
C5760	Stage_III_Hepatocellular_Carcinoma	Hepatocellular_Carcinoma|Stage_III_Liver_Cancer	Stage III Hepatocellular Carcinoma|Hepatocellular Cancer Stage III|Liver Cell Cancer Stage III|Stage III Carcinoma of Liver Cells|Stage III Carcinoma of the Liver Cells|Stage III Hepatocellular Cancer|Stage III Liver Cell Cancer
C5761	Stage_IIIA_Hepatocellular_Carcinoma	Stage_IIIA_Liver_Cancer|Stage_III_Hepatocellular_Carcinoma	Stage IIIA Hepatocellular Carcinoma|Stage IIIA Carcinoma of Liver Cells|Stage IIIA Carcinoma of the Liver Cells|Stage IIIA Liver Cell Carcinoma
C5762	Stage_IIIB_Hepatocellular_Carcinoma	Stage_IIIB_Liver_Cancer|Stage_III_Hepatocellular_Carcinoma	Stage IIIB Hepatocellular Carcinoma|Stage IIIB Carcinoma of Liver Cells|Stage IIIB Carcinoma of the Liver Cells|Stage IIIB Liver Cell Carcinoma
C5763	Stage_IV_Hepatocellular_Carcinoma	Hepatocellular_Carcinoma|Stage_IV_Liver_Cancer	Stage IV Hepatocellular Carcinoma|Hepatocellular Cancer Stage IV|Liver Cell Cancer Stage IV|Stage IV Hepatocellular Cancer|Stage IV Liver Cell Cancer|Stage IV Liver Cell Carcinoma
C5764	Stage_IVA_Hepatocellular_Carcinoma	Stage_IVA_Liver_Cancer|Stage_IV_Hepatocellular_Carcinoma	Stage IVA Hepatocellular Carcinoma|Stage IVA Liver Cell Carcinoma
C5765	Stage_IVB_Hepatocellular_Carcinoma	Stage_IVB_Liver_Cancer|Stage_IV_Hepatocellular_Carcinoma	Stage IVB Hepatocellular Carcinoma|Stage IVB Carcinoma of Liver Cells|Stage IVB Carcinoma of the Liver Cells|Stage IVB Liver Cell Carcinoma
C5766	Hepatic_Non-Hodgkin_s_Lymphoma	Gastrointestinal_Non-Hodgkin_s_Lymphoma|Hepatic_Lymphoma	Hepatic Non-Hodgkin's Lymphoma|Hepatic Non-Hodgkin Lymphoma|Non-Hodgkin's Liver Lymphoma|Non-Hodgkin's Lymphoma of Liver|Non-Hodgkin's Lymphoma of the Liver|Primary Hepatic Non-Hodgkin's Lymphoma
C5768	Hepatic_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue|Hepatic_Non-Hodgkin_s_Lymphoma	Hepatic Mucosa-Associated Lymphoid Tissue Lymphoma|Hepatic MALToma|Liver MALToma|MALT Hepatic Lymphoma|MALT Liver Lymphoma|MALT Lymphoma of Liver|MALT Lymphoma of the Liver|MALToma of Liver|MALToma of the Liver|Mucosa-Associated Lymphoid Tissue Liver Lymphoma|Mucosa-Associated Lymphoid Tissue Lymphoma of Liver|Mucosa-Associated Lymphoid Tissue Lymphoma of the Liver
C5769	Stage_I_Extrahepatic_Bile_Duct_Cancer	Extrahepatic_Bile_Duct_Carcinoma	Stage I Extrahepatic Bile Duct Cancer|Extrahepatic Bile Duct Cancer Stage I|Stage I Carcinoma of Extrahepatic Bile Duct|Stage I Carcinoma of the Extrahepatic Bile Duct|Stage I Extrahepatic Bile Duct Carcinoma	Stage I includes: IA: (T1, N0, M0); IB: (T2, N0, M0).  T1: Tumor confined to the bile duct histologically.  T2: Tumor invades beyond the wall of the bile duct.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C5770	Stage_II_Extrahepatic_Bile_Duct_Cancer	Extrahepatic_Bile_Duct_Carcinoma	Stage II Extrahepatic Bile Duct Cancer|Extrahepatic Bile Duct Cancer Stage II|Stage II Carcinoma of Extrahepatic Bile Duct|Stage II Carcinoma of the Extrahepatic Bile Duct|Stage II Extrahepatic Bile Duct Carcinoma	Stage II includes: IIA: (T3, N0, M0); IIB: (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: Tumor invades the liver, gallbladder, pancreas, and/or unilateral branches or the portal vein (right or left) or hepatic artery (right or left).  N1: Regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C5771	Stage_III_Extrahepatic_Bile_Duct_Cancer	Extrahepatic_Bile_Duct_Carcinoma	Stage III Extrahepatic Bile Duct Cancer|Extrahepatic Bile Duct Cancer Stage III|Stage III Carcinoma of Extrahepatic Bile Duct|Stage III Carcinoma of the Extrahepatic Bile Duct|Stage III Extrahepatic Bile Duct Carcinoma	Stage III includes: T4, Any N, M0.  T4: Tumor invades any of the following main portal vein or its branches bilaterally, common hepatic artery, or other adjacent structures, such as the colon, stomach, duodenum, or abdominal wall.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: Distant metastasis. (AJCC 6th ed.) - 2003
C5772	Stage_IV_Extrahepatic_Bile_Duct_Cancer	Extrahepatic_Bile_Duct_Carcinoma	Stage IV Extrahepatic Bile Duct Cancer|Extrahepatic Bile Duct Cancer Stage IV|Stage IV Carcinoma of Extrahepatic Bile Duct|Stage IV Carcinoma of the Extrahepatic Bile Duct|Stage IV Extrahepatic Bile Duct Carcinoma	Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis. (AJCC 6th ed.) - 2003
C5773	Stage_IVA_Extrahepatic_Bile_Duct_Cancer	Stage_IV_Extrahepatic_Bile_Duct_Cancer	Stage IVA Extrahepatic Bile Duct Cancer|Extrahepatic Bile Duct Cancer Stage IVA|Stage IVA Carcinoma of Extrahepatic Bile Duct|Stage IVA Carcinoma of the Extrahepatic Bile Duct|Stage IVA Extrahepatic Bile Duct Carcinoma
C5774	Stage_IVB_Extrahepatic_Bile_Duct_Cancer	Stage_IV_Extrahepatic_Bile_Duct_Cancer	Stage IVB Extrahepatic Bile Duct Cancer|Extrahepatic Bile Duct Cancer Stage IVB|Stage IVB Carcinoma of Extrahepatic Bile Duct|Stage IVB Carcinoma of the Extrahepatic Bile Duct|Stage IVB Extrahepatic Bile Duct Carcinoma
C5775	Clear_Cell_Bile_Duct_Adenocarcinoma	Clear_Cell_Adenocarcinoma|Extrahepatic_Bile_Duct_Adenocarcinoma	Bile Duct Clear Cell Adenocarcinoma|Clear Cell Adenocarcinoma of Bile Duct|Clear Cell Adenocarcinoma of the Bile Duct|Clear Cell Bile Duct Adenocarcinoma	A morphologic variant of bile duct adenocarcinoma characterized by the presence of malignant glandular epithelium composed of clear cells.
C5776	Signet_Ring_Cell_Bile_Duct_Carcinoma	Extrahepatic_Bile_Duct_Adenocarcinoma|Signet_Ring_Cell_Carcinoma	Bile Duct Signet Ring Cell Carcinoma|Signet Ring Cell Bile Duct Carcinoma|Signet Ring Cell Carcinoma of Bile Duct|Signet Ring Cell Carcinoma of the Bile Duct
C5777	Squamous_Cell_Bile_Duct_Carcinoma	Extrahepatic_Bile_Duct_Carcinoma|Squamous_Cell_Carcinoma	Squamous Cell Bile Duct Carcinoma|Bile Duct Squamous Cell Carcinoma|Squamous Cell Carcinoma of Bile Duct|Squamous Cell Carcinoma of the Bile Duct
C5778	Adenosquamous_Bile_Duct_Carcinoma	Adenosquamous_Carcinoma|Extrahepatic_Bile_Duct_Carcinoma	Adenosquamous Bile Duct Carcinoma|Adenosquamous Carcinoma of Bile Duct|Adenosquamous Carcinoma of the Bile Duct|Bile Duct Adenosquamous Carcinoma
C5780	Undifferentiated_Extrahepatic_Bile_Duct_Carcinoma	Extrahepatic_Bile_Duct_Carcinoma|Undifferentiated_Carcinoma	Undifferentiated Extrahepatic Bile Duct Carcinoma|Anaplastic Carcinoma of Extrahepatic Bile Duct|Anaplastic Carcinoma of the Extrahepatic Bile Duct|Anaplastic Extrahepatic Bile Duct Carcinoma|Undifferentiated Carcinoma of Extrahepatic Bile Duct|Undifferentiated Carcinoma of the Extrahepatic Bile Duct
C5783	Hepatic_Carcinoid_Tumor	Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Gastrointestinal_Carcinoid_Tumor|Hepatic_Disorder|Midgut_Carcinoid_Tumor	Hepatic Carcinoid Tumor|Carcinoid Neoplasm of Liver|Carcinoid Neoplasm of the Liver|Carcinoid Tumor of Liver|Carcinoid Tumor of the Liver|Hepatic Carcinoid Neoplasm|Liver Carcinoid Neoplasm|Liver Carcinoid Tumor
C5787	Jejunal_Delta_Cell_Somatostatin_Producing_Neoplasm	Jejunal_Neoplasm|Small_Intestinal_Delta_Cell_Somatostatin_Producing_Neoplasm	Jejunal Somatostatin Producing Tumor|Delta Cell Tumor of Jejunum|Delta Cell Tumor of the Jejunum|Jejunal Somatostatin Producing Neoplasm|Jejunal Somatostatinoma|Somatosatinoma of Jejunum|Somatosatinoma of the Jejunum
C5789	Pancreatic_Non-Hodgkin_s_Lymphoma	Gastrointestinal_Non-Hodgkin_s_Lymphoma|Pancreatic_Lymphoma	Pancreatic Non-Hodgkin's Lymphoma|Pancreatic Non-Hodgkin Lymphoma|Primary Pancreatic Non-Hodgkin's Lymphoma
C5790	Adult_Central_Nervous_System_Embryonal_Carcinoma	Adult_Central_Nervous_System_Germ_Cell_Neoplasm|Extragonadal_Embryonal_Carcinoma	Adult Central Nervous System Embryonal Carcinoma|Adult CNS Embryonal Carcinoma|Embryonal Carcinoma of Adult CNS|Embryonal Carcinoma of Adult Central Nervous System|Embryonal Carcinoma of the Adult CNS|Embryonal Carcinoma of the Adult Central Nervous System
C5792	Adult_Central_Nervous_System_Germinoma	Adult_Central_Nervous_System_Germ_Cell_Neoplasm|Germinoma_of_the_Central_Nervous_System|Malignant_Extragonadal_Germ_Cell_Tumor	Adult Central Nervous System Germinoma|Adult CNS Germinoma|Germinoma of Adult CNS|Germinoma of Adult Central Nervous System|Germinoma of the Adult CNS|Germinoma of the Adult Central Nervous System
C5793	Adult_Central_Nervous_System_Choriocarcinoma	Adult_Central_Nervous_System_Germ_Cell_Neoplasm|Central_Nervous_System_Choriocarcinoma|Malignant_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor	Adult Central Nervous System Choriocarcinoma|Adult CNS Choriocarcinoma|Choriocarcinoma of Adult CNS|Choriocarcinoma of Adult Central Nervous System|Choriocarcinoma of the Adult CNS|Choriocarcinoma of the Adult Central Nervous System
C5794	Adult_Central_Nervous_System_Teratoma	Adult_Central_Nervous_System_Germ_Cell_Neoplasm|Central_Nervous_System_Teratoma	Adult Central Nervous System Teratoma|Adult CNS Teratoma|Teratoma of Adult CNS|Teratoma of Adult Central Nervous System|Teratoma of the Adult CNS|Teratoma of the Adult Central Nervous System
C5795	Childhood_Brain_Germ_Cell_Neoplasm	Childhood_Brain_Neoplasm|Childhood_Central_Nervous_System_Germ_Cell_Neoplasm	Childhood Brain Germ Cell Tumor|Childhood Brain Germ Cell Neoplasm|Childhood Germ Cell Brain Neoplasm|Childhood Germ Cell Brain Tumor|Germ Cell Neoplasm of Childhood Brain|Germ Cell Neoplasm of Pediatric Brain|Germ Cell Neoplasm of the Childhood Brain|Germ Cell Neoplasm of the Pediatric Brain|Germ Cell Tumor of Childhood Brain|Germ Cell Tumor of Pediatric Brain|Germ Cell Tumor of the Childhood Brain|Germ Cell Tumor of the Pediatric Brain|Pediatric Brain Germ Cell Neoplasm|Pediatric Brain Germ Cell Tumor
C5796	Benign_Adult_Cerebellar_Neoplasm	Adult_Cerebellar_Neoplasm|Benign_Adult_Brain_Neoplasm|Benign_Cerebellar_Neoplasm	Benign Adult Cerebellar Neoplasm|Adult Benign Cerebellar Neoplasms|Benign Adult Cerebellar Tumor|Benign Adult Cerebellar Tumors|Benign Neoplasm of Adult Cerebellum|Benign Neoplasm of the Adult Cerebellum|Benign Tumor of Adult Cerebellum|Benign Tumor of the Adult Cerebellum
C5797	Benign_Adult_Brain_Stem_Neoplasm	Adult_Brain_Stem_Neoplasm|Benign_Adult_Brain_Neoplasm|Benign_Brain_Stem_Neoplasm	Benign Adult Brain Stem Neoplasm|Adult Benign Brain Stem Neoplasms|Benign Adult Brain Stem Tumor|Benign Adult Brain Stem Tumors|Benign Adult Brainstem Neoplasm|Benign Adult Brainstem Neoplasms|Benign Adult Brainstem Tumor|Benign Adult Brainstem Tumors|Benign Neoplasm of Adult Brain Stem|Benign Neoplasm of Adult Brainstem|Benign Neoplasm of the Adult Brain Stem|Benign Neoplasm of the Adult Brainstem|Benign Tumor of Adult Brain Stem|Benign Tumor of Adult Brainstem|Benign Tumor of the Adult Brain Stem|Benign Tumor of the Adult Brainstem
C5798	Benign_Childhood_Brain_Neoplasm	Benign_Brain_Neoplasm|Benign_Childhood_Central_Nervous_System_Neoplasm|Childhood_Brain_Neoplasm	Benign Childhood Brain Neoplasm|Benign Childhood Brain Tumor|Benign Childhood Neoplasm of Brain|Benign Childhood Neoplasm of the Brain|Benign Childhood Tumor of Brain|Benign Childhood Tumor of the Brain|Benign Pediatric Brain Neoplasm|Benign Pediatric Brain Tumor|Benign Pediatric Neoplasm of Brain|Benign Pediatric Neoplasm of the Brain|Benign Pediatric Tumor of Brain|Benign Pediatric Tumor of the Brain|Childhood Benign Brain Neoplasms
C5799	Benign_Childhood_Supratentorial_Neoplasm	Benign_Childhood_Brain_Neoplasm|Benign_Supratentorial_Neoplasm|Childhood_Supratentorial_Neoplasm	Benign Childhood Supratentorial Neoplasm|Benign Childhood Supratentorial Tumor|Benign Pediatric Supratentorial Neoplasm|Benign Pediatric Supratentorial Tumor|Childhood Benign Supratentorial Neoplasms|Childhood Benign Supratentorial Tumors
C5800	Childhood_Choroid_Plexus_Papilloma	Benign_Childhood_Supratentorial_Neoplasm|Childhood_Choroid_Plexus_Neoplasm|Choroid_Plexus_Papilloma	Childhood Choroid Plexus Papilloma|Childhood Papilloma of Choroid Plexus|Childhood Papilloma of the Choroid Plexus|Pediatric Choroid Plexus Papilloma|Pediatric Papilloma of Choroid Plexus|Pediatric Papilloma of the Choroid Plexus
C5801	Childhood_Cerebral_Cyst	Cerebral_Cyst	Childhood Cerebral Cyst|Childhood Cyst of the Cerebrum|Pediatric Cerebral Cyst|Pediatric Cyst of the Cerebrum
C5802	Childhood_Infratentorial_Neoplasm	Childhood_Brain_Neoplasm|Infratentorial_Neoplasm	Childhood Infratentorial Neoplasm|Childhood Infratentorial Neoplasms|Childhood Infratentorial Tumor|Childhood Infratentorial Tumors|Pediatric Infratentorial Neoplasm|Pediatric Infratentorial Tumor
C5803	Small_Intestinal_Neuroendocrine_Neoplasm	Intestinal_Neuroendocrine_Neoplasm|Small_Intestinal_Neoplasm	Small Intestinal Neuroendocrine Neoplasm|Small Intestine Neuroendocrine Neoplasm|Small Intestine Neuroendocrine Tumor
C5806	Gastric_Gastrointestinal_Stromal_Tumor	Gastric_Mesenchymal_Neoplasm|Gastrointestinal_Stromal_Tumor_of_the_Gastrointestinal_Tract	Gastric Gastrointestinal Stromal Tumor|Digestive Stromal Neoplasm of Stomach|Digestive Stromal Neoplasm of the Stomach|Digestive Stromal Tumor of Stomach|Digestive Stromal Tumor of the Stomach|GIST of Stomach|GIST of the Stomach|Gastric Digestive Stromal Neoplasm|Gastric Digestive Stromal Tumor|Gastric GIST|Gastrointestinal Stromal Neoplasm of Stomach|Gastrointestinal Stromal Neoplasm of the Stomach|Gastrointestinal Stromal Tumor of Stomach|Gastrointestinal Stromal Tumor of the Stomach|Stomach Digestive Stromal Neoplasm|Stomach Digestive Stromal Tumor
C5807	Stage_I_Small_Intestinal_Cancer	Small_Intestinal_Carcinoma	Stage I Small Intestinal Cancer|Small Intestine Cancer Stage I|Stage I Small Intestine Carcinoma
C5808	Stage_II_Small_Intestinal_Cancer	Small_Intestinal_Carcinoma	Stage II Small Intestinal Cancer|Small Intestine Cancer Stage II|Stage II Small Intestine Carcinoma
C5809	Stage_III_Small_Intestinal_Cancer	Small_Intestinal_Carcinoma	Stage III Small Intestinal Cancer|Small Intestine Cancer Stage III|Stage III Small Intestine Carcinoma
C5810	Stage_IV_Small_Intestinal_Cancer	Small_Intestinal_Carcinoma	Stage IV Small Intestinal Cancer|Small Intestine Cancer Stage IV|Stage IV Small Intestine Carcinoma
C5811	Small_Intestinal_Gastrointestinal_Stromal_Tumor	Gastrointestinal_Stromal_Tumor_of_the_Gastrointestinal_Tract|Small_Intestinal_Neoplasm	Small Intestinal Gastrointestinal Stromal Tumor|Digestive Stromal Neoplasm of Small Intestine|Digestive Stromal Neoplasm of the Small Intestine|Digestive Stromal Tumor of Small Intestine|Digestive Stromal Tumor of the Small Intestine|Gastrointestinal Stromal Neoplasm of Small Intestine|Gastrointestinal Stromal Neoplasm of the Small Intestine|Gastrointestinal Stromal Tumor of Small Intestine|Gastrointestinal Stromal Tumor of the Small Intestine|Small Intestinal GIST|Small Intestine Digestive Stromal Neoplasm|Small Intestine Digestive Stromal Tumor|Small Intestine Gastrointestinal Stromal Neoplasm
C5814	Adult_Third_Ventricle_Colloid_Cyst	Central_Nervous_System_Colloid_Cyst|Third_Ventricle_Colloid_Cyst	Adult Third Ventricle Colloid Cyst|Adult Colloid Cyst of the Third Ventricle|Adult Third Ventricle Neuroepithelial Cyst|Adult Third Ventricle Paraphyseal Cyst|Neuroepithelial Cyst of the Adult Third Ventricle|Paraphyseal Cyst of the Adult Third Ventricle
C5815	Childhood_Third_Ventricle_Colloid_Cyst	Central_Nervous_System_Colloid_Cyst|Third_Ventricle_Colloid_Cyst	Childhood Third Ventricle Colloid Cyst|Childhood Colloid Cyst of the Third Ventricle|Childhood Hypophyseal Cyst of the Third Ventricle|Childhood Neuroepithelial Cyst of the Third Ventricle|Childhood Third Ventricle Hypophyseal Cyst|Childhood Third Ventricle Neuroepithelial Cyst|Pediatric Colloid Cyst of the Third Ventricle|Pediatric Hypophyseal Cyst of the Third Ventricle|Pediatric Neuroepithelial Cyst of the Third Ventricle|Pediatric Third Ventricle Colloid Cyst|Pediatric Third Ventricle Hypophyseal Cyst|Pediatric Third Ventricle Neuroepithelial Cyst
C5816	Metastatic_Neoplasm_to_the_Adult_Brain	Malignant_Adult_Brain_Neoplasm|Metastatic_Neoplasm_to_the_Brain	Metastatic Malignant Neoplasm to the Adult Brain|Brain Metastases, Adult|Metastasis to the Adult Brain|Metastatic Neoplasm to the Adult Brain|Metastatic Tumor to the Adult Brain|Secondary Malignant Neoplasm to the Adult Brain|Secondary Malignant Tumor to the Adult Brain
C5817	Intracranial_Primitive_Neuroectodermal_Neoplasm	Intracranial_Neoplasm	Intracranial Primitive Neuroectodermal Neoplasm|Intracranial PNET|Intracranial Primitive Neuroectodermal Tumor
C5818	Pharyngeal_Adenoid_Cystic_Carcinoma	Adenoid_Cystic_Carcinoma|Pharyngeal_Carcinoma	Pharyngeal Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Pharynx|Adenoid Cystic Carcinoma of the Pharynx|Pharynx Adenoid Cystic Carcinoma
C5819	Buccal_Mucosa_Papilloma	Benign_Buccal_Mucosa_Neoplasm|Papilloma	Buccal Mucosa Papilloma|Papilloma of Buccal Mucosa|Papilloma of the Buccal Mucosa
C5820	Esophageal_Carcinoid_Tumor	Esophageal_Neuroendocrine_Neoplasm|Foregut_Carcinoid_Tumor|Gastrointestinal_Carcinoid_Tumor	Esophageal Carcinoid Tumor|Carcinoid Neoplasm of Esophagus|Carcinoid Neoplasm of the Esophagus|Carcinoid Tumor of Esophagus|Carcinoid Tumor of the Esophagus|Esophageal Carcinoid Neoplasm	Carcinoid tumors are rarely reported in the esophagus.  The majority of cases are males in their 5th decade.  Carcinoid tumors are typically located in the lower third of the esophagus, are of large size, and infiltrate deeply the esophageal wall.  (WHO, 2000) -- 2003
C5821	Esophageal_Neuroendocrine_Neoplasm	Esophageal_Neoplasm|Gastrointestinal_Neuroendocrine_Neoplasm	Esophageal Neuroendocrine Neoplasm|Esophageal Neuroendocrine Tumor|Neuroendocrine Neoplasm of Esophagus|Neuroendocrine Neoplasm of the Esophagus|Neuroendocrine Tumor of Esophagus|Neuroendocrine Tumor of the Esophagus	These neoplasms are rare in the esophagus, and include carcinoid tumor and small cell carcinoma.  (WHO, 2000) -- 2003
C5822	Nerve_Plexus_Neoplasm	Peripheral_Nervous_System_Neoplasm	Nerve Plexus Neoplasm|Neoplasm of Nerve Plexus|Neoplasm of the Nerve Plexus|Nerve Plexus Neoplasms|Nerve Plexus Tumor|Nerve Plexus Tumors|Neural Plexus Neoplasms|Neural Plexus Tumors|Tumor of Nerve Plexus|Tumor of the Nerve Plexus
C5823	Brachial_Plexus_Neoplasm	Nerve_Plexus_Neoplasm	Brachial Plexus Neoplasm|Brachial Plexus Neoplasms|Brachial Plexus Tumor|Neoplasm of Brachial Plexus|Neoplasm of the Brachial Plexus|Tumor of Brachial Plexus|Tumor of the Brachial Plexus
C5824	Lumbar_Plexus_Neoplasm	Nerve_Plexus_Neoplasm	Lumbar Plexus Neoplasm|Lumbar Plexus Neoplasms|Lumbar Plexus Tumor|Neoplasm of Lumbar Plexus|Neoplasm of the Lumbar Plexus|Tumor of Lumbar Plexus|Tumor of the Lumbar Plexus
C5825	Trochlear_Nerve_Neoplasm	Cranial_Nerve_Neoplasm	Trochlear Nerve Neoplasm|Fourth Cranial Nerve Neoplasm|Fourth Cranial Nerve Neoplasms|Fourth Cranial Nerve Tumor|Fourth Cranial Nerve Tumors|IVth Cranial Nerve Neoplasms|IVth Cranial Nerve Tumors|Neoplasm of Fourth Cranial Nerve|Neoplasm of Trochlear Nerve|Neoplasm of the Fourth Cranial Nerve|Neoplasm of the Trochlear Nerve|Trochlear Nerve Neoplasms|Trochlear Nerve Tumor|Trochlear Nerve Tumors|Tumor of Fourth Cranial Nerve|Tumor of Trochlear Nerve|Tumor of the Fourth Cranial Nerve|Tumor of the Trochlear Nerve
C5826	Abducens_Nerve_Neoplasm	Abducens_Nerve_Disorder|Cranial_Nerve_Neoplasm	Abducens Nerve Neoplasm|Abducens Nerve Neoplasms|Abducens Nerve Tumor|Abducens Nerve Tumors|Neoplasm of Abducens Nerve|Neoplasm of Sixth Cranial Nerve|Neoplasm of the Abducens Nerve|Neoplasm of the Sixth Cranial Nerve|Sixth Cranial Nerve Neoplasm|Sixth Cranial Nerve Neoplasms|Sixth Cranial Nerve Tumor|Sixth Cranial Nerve Tumors|Tumor of Abducens Nerve|Tumor of Sixth Cranial Nerve|Tumor of the Abducens Nerve|Tumor of the Sixth Cranial Nerve|VIth Cranial Nerve Neoplasms|VIth Cranial Nerve Tumors
C5827	Facial_Nerve_Neoplasm	Cranial_Nerve_Neoplasm|Facial_Nerve_Disorder	Facial Nerve Neoplasm|Facial Nerve Neoplasms|Facial Nerve Tumor|Facial Nerve Tumors|Neoplasm of Facial Nerve|Neoplasm of Seventh Cranial Nerve|Neoplasm of the Facial Nerve|Neoplasm of the Seventh Cranial Nerve|Seventh Cranial Nerve Neoplasm|Seventh Cranial Nerve Neoplasms|Seventh Cranial Nerve Tumor|Seventh Cranial Nerve Tumors|Tumor of Facial Nerve|Tumor of Seventh Cranial Nerve|Tumor of the Facial Nerve|Tumor of the Seventh Cranial Nerve|VIIth Cranial Nerve Neoplasms|VIIth Cranial Nerve Tumors
C5828	Glossopharyngeal_Nerve_Neoplasm	Cranial_Nerve_Neoplasm|Glossopharyngeal_Nerve_Disorder	Glossopharyngeal Nerve Neoplasm|Glossopharyngeal Nerve Neoplasms|Glossopharyngeal Nerve Tumor|Glossopharyngeal Nerve Tumors|IXth Cranial Nerve Neoplasms|IXth Cranial Nerve Tumors|Neoplasm of Glossopharyngeal Nerve|Neoplasm of Ninth Cranial Nerve|Neoplasm of the Glossopharyngeal Nerve|Neoplasm of the Ninth Cranial Nerve|Ninth Cranial Nerve Neoplasm|Ninth Cranial Nerve Neoplasms|Ninth Cranial Nerve Tumor|Ninth Cranial Nerve Tumors|Tumor of Glossopharyngeal Nerve|Tumor of Ninth Cranial Nerve|Tumor of the Glossopharyngeal Nerve|Tumor of the Ninth Cranial Nerve
C5829	Spinal_Accessory_Nerve_Neoplasm	Cranial_Nerve_Neoplasm	Spinal Accessory Nerve Neoplasm|Eleventh Cranial Nerve Neoplasm|Eleventh Cranial Nerve Neoplasms|Eleventh Cranial Nerve Tumor|Eleventh Cranial Nerve Tumors|Neoplasm of Eleventh Cranial Nerve|Neoplasm of Spinal Accessory Nerve|Neoplasm of the Eleventh Cranial Nerve|Neoplasm of the Spinal Accessory Nerve|Spinal Accessory Nerve Neoplasms|Spinal Accessory Nerve Tumor|Spinal Accessory Nerve Tumors|Tumor of Eleventh Cranial Nerve|Tumor of Spinal Accessory Nerve|Tumor of the Eleventh Cranial Nerve|Tumor of the Spinal Accessory Nerve|XIth Cranial Nerve Neoplasms|XIth Cranial Nerve Tumors
C5830	Hypoglossal_Nerve_Neoplasm	Cranial_Nerve_Neoplasm|Hypoglossal_Nerve_Disorder	Hypoglossal Nerve Neoplasm|Hypoglossal Nerve Neoplasms|Hypoglossal Nerve Tumor|Hypoglossal Nerve Tumors|Neoplasm of Hypoglossal Nerve|Neoplasm of Twelfth Cranial Nerve|Neoplasm of the Hypoglossal Nerve|Neoplasm of the Twelfth Cranial Nerve|Tumor of Hypoglossal Nerve|Tumor of Twelfth Cranial Nerve|Tumor of the Hypoglossal Nerve|Tumor of the Twelfth Cranial Nerve|Twelfth Cranial Nerve Neoplasm|Twelfth Cranial Nerve Neoplasms|Twelfth Cranial Nerve Tumor|Twelfth Cranial Nerve Tumors|XIIth Cranial Nerve Neoplasms|XIIth Cranial Nerve Tumors
C5831	Vagus_Nerve_Neoplasm	Cranial_Nerve_Neoplasm|Vagus_Nerve_Disorder	Vagus Nerve Neoplasm|Neoplasm of Tenth Cranial Nerve|Neoplasm of Vagus Nerve|Neoplasm of the Tenth Cranial Nerve|Neoplasm of the Vagus Nerve|Tenth Cranial Nerve Neoplasm|Tenth Cranial Nerve Neoplasms|Tenth Cranial Nerve Tumor|Tenth Cranial Nerve Tumors|Tumor of Tenth Cranial Nerve|Tumor of Vagus Nerve|Tumor of the Tenth Cranial Nerve|Tumor of the Vagus Nerve|Vagus Nerve Neoplasms|Vagus Nerve Tumor|Vagus Nerve Tumors|Xth Cranial Nerve Neoplasms|Xth Cranial Nerve Tumors
C5832	Hepatic_Fibrosarcoma	Hepatic_Sarcoma|Soft_Tissue_Fibrosarcoma	Hepatic Fibrosarcoma|Fibrosarcoma of Liver|Fibrosarcoma of the Liver|Liver Fibrosarcoma
C5833	Hepatic_Osteosarcoma	Extraskeletal_Osteosarcoma|Hepatic_Sarcoma	Hepatic Osteosarcoma|Hepatic Osteogenic Sarcoma|Liver Osteogenic Sarcoma|Liver Osteosarcoma|Osteogenic Sarcoma of Liver|Osteogenic Sarcoma of the Liver|Osteosarcoma of Liver|Osteosarcoma of the Liver
C5834	Hepatic_Rhabdomyosarcoma	Hepatic_Sarcoma|Rhabdomyosarcoma	Hepatic Rhabdomyosarcoma|Liver Rhabdomyosarcoma|Rhabdomyosarcoma of Liver|Rhabdomyosarcoma of the Liver
C5835	Gallbladder_Lipoma	Benign_Non-Epithelial_Gallbladder_Neoplasm|Lipoma	Gallbladder Lipoma|Lipoma of Gallbladder|Lipoma of the Gallbladder
C5838	Gallbladder_Pleomorphic_Giant_Cell_Adenocarcinoma	Gallbladder_Adenocarcinoma	Gallbladder Pleomorphic Giant Cell Adenocarcinoma|Pleomorphic Giant Cell Adenocarcinoma of Gallbladder|Pleomorphic Giant Cell Adenocarcinoma of the Gallbladder
C5839	Gallbladder_Rhabdomyosarcoma	Gallbladder_Sarcoma|Rhabdomyosarcoma	Gallbladder Rhabdomyosarcoma|Rhabdomyosarcoma of Gallbladder|Rhabdomyosarcoma of the Gallbladder
C5840	Gallbladder_Angiosarcoma	Angiosarcoma|Gallbladder_Sarcoma	Gallbladder Angiosarcoma|Angiosarcoma of Gallbladder|Angiosarcoma of the Gallbladder|Gallbladder Hemangiosarcoma|Hemangiosarcoma of Gallbladder|Hemangiosarcoma of the Gallbladder
C5841	Gallbladder_Leiomyosarcoma	Gallbladder_Sarcoma|Leiomyosarcoma	Gallbladder Leiomyosarcoma|Leiomyosarcoma of Gallbladder|Leiomyosarcoma of the Gallbladder
C5842	Gallbladder_Kaposi_s_Sarcoma	Gallbladder_Sarcoma|Kaposi_s_Sarcoma	Gallbladder Kaposi's Sarcoma|Kaposi's Sarcoma of Gallbladder|Kaposi's Sarcoma of the Gallbladder
C5845	Small_Cell_Extrahepatic_Bile_Duct_Carcinoma	Extrahepatic_Bile_Duct_Carcinoma	Small Cell Extrahepatic Bile Duct Carcinoma|Oat Cell Carcinoma of Extrahepatic Bile Duct|Oat Cell Carcinoma of the Extrahepatic Bile Duct|Oat Cell Extrahepatic Bile Duct Carcinoma|Small Cell Adenocarcinoma of Extrahepatic Bile Duct|Small Cell Adenocarcinoma of the Extrahepatic Bile Duct
C5846	Mucinous_Bile_Duct_Adenocarcinoma	Extrahepatic_Bile_Duct_Adenocarcinoma|Mucinous_Adenocarcinoma	Bile Duct Mucinous Adenocarcinoma|Bile Duct Colloid Carcinoma|Bile Duct Colloidal Carcinoma|Colloid Adenocarcinoma of Bile Duct|Colloid Adenocarcinoma of Extrahepatic Bile Duct|Colloid Adenocarcinoma of the Bile Duct|Colloid Adenocarcinoma of the Extrahepatic Bile Duct|Colloid Bile Duct Adenocarcinoma|Colloid Bile Duct Carcinoma|Colloid Carcinoma of Bile Duct|Colloid Carcinoma of the Bile Duct|Colloid Extrahepatic Bile Duct Adenocarcinoma|Colloidal Adenocarcinoma of Bile Duct|Colloidal Adenocarcinoma of Extrahepatic Bile Duct|Colloidal Adenocarcinoma of the Bile Duct|Colloidal Adenocarcinoma of the Extrahepatic Bile Duct|Colloidal Bile Duct Adenocarcinoma|Colloidal Bile Duct Carcinoma|Colloidal Carcinoma of Bile Duct|Colloidal Carcinoma of the Bile Duct|Colloidal Extrahepatic Bile Duct Adenocarcinoma|Mucinous Adenocarcinoma of Bile Duct|Mucinous Adenocarcinoma of Extrahepatic Bile Duct|Mucinous Adenocarcinoma of the Bile Duct|Mucinous Adenocarcinoma of the Extrahepatic Bile Duct|Mucinous Bile Duct Adenocarcinoma|Mucinous Carcinoma of Bile Duct|Mucinous Carcinoma of the Bile Duct|Mucinous Extrahepatic Bile Duct Adenocarcinoma
C5847	Extrahepatic_Bile_Duct_Embryonal_Rhabdomyosarcoma	Bile_Duct_Rhabdomyosarcoma|Embryonal_Rhabdomyosarcoma	Extrahepatic Bile Duct Embryonal Rhabdomyosarcoma|Embryonal Extrahepatic Bile Duct Rhabdomyosarcoma|Embryonal Rhabdomyosarcoma of Extrahepatic Bile Duct|Embryonal Rhabdomyosarcoma of the Extrahepatic Bile Duct
C5848	Extrahepatic_Bile_Duct_Leiomyosarcoma	Bile_Duct_Sarcoma|Leiomyosarcoma	Extrahepatic Bile Duct Leiomyosarcoma|Bile Duct Leiomyosarcoma|Leiomyosarcoma of Bile Duct|Leiomyosarcoma of Extrahepatic Bile Duct|Leiomyosarcoma of the Bile Duct|Leiomyosarcoma of the Extrahepatic Bile Duct
C5849	Extrahepatic_Bile_Duct_Papillary_Adenoma	Extrahepatic_Bile_Duct_Adenoma	Extrahepatic Bile Duct Papillary Adenoma|Papillary Adenoma of Extrahepatic Bile Duct|Papillary Adenoma of the Extrahepatic Bile Duct
C5850	Extrahepatic_Bile_Duct_Tubular_Adenoma	Extrahepatic_Bile_Duct_Adenoma|Tubular_Adenoma	Extrahepatic Bile Duct Tubular Adenoma|Tubular Adenoma of Extrahepatic Bile Duct|Tubular Adenoma of the Extrahepatic Bile Duct
C5851	Extrahepatic_Bile_Duct_Cystadenoma	Benign_Extrahepatic_Bile_Duct_Neoplasm|Bile_Duct_Cystadenoma	Extrahepatic Bile Duct Cystadenoma|Cystadenoma of Extrahepatic Bile Duct|Cystadenoma of the Extrahepatic Bile Duct
C5852	Benign_Granular_Cell_Tumor_of_Extrahepatic_Bile_Ducts	Benign_Extrahepatic_Bile_Duct_Non-Epithelial_Neoplasm|Benign_Granular_Cell_Tumor	Benign Granular Cell Tumor of Extrahepatic Bile Ducts|Benign Extrahepatic Bile Duct Granular Cell Myoblastoma|Benign Granular Cell Myoblastoma of Extrahepatic Bile Duct|Benign Granular Cell Myoblastoma of the Extrahepatic Bile Duct
C5853	Extrahepatic_Bile_Duct_Fibroma	Benign_Extrahepatic_Bile_Duct_Mesenchymal_Neoplasm|Fibroma	Extrahepatic Bile Duct Fibroma|Fibroma of Extrahepatic Bile Duct|Fibroma of the Extrahepatic Bile Duct
C5854	Extrahepatic_Bile_Duct_Lipoma	Benign_Extrahepatic_Bile_Duct_Mesenchymal_Neoplasm|Lipoma	Extrahepatic Bile Duct Lipoma|Lipoma of Extrahepatic Bile Duct|Lipoma of the Extrahepatic Bile Duct
C5855	Extrahepatic_Bile_Duct_Leiomyoma	Benign_Extrahepatic_Bile_Duct_Mesenchymal_Neoplasm|Leiomyoma	Extrahepatic Bile Duct Leiomyoma|Leiomyoma of Extrahepatic Bile Duct|Leiomyoma of the Extrahepatic Bile Duct
C5856	Benign_Extrahepatic_Bile_Duct_Mesenchymal_Neoplasm	Benign_Extrahepatic_Bile_Duct_Non-Epithelial_Neoplasm	Benign Extrahepatic Bile Duct Mesenchymal Neoplasm|Benign Extrahepatic Bile Duct Mesenchymal Tumor|Benign Mesenchymal Neoplasm of Extrahepatic Bile Duct|Benign Mesenchymal Neoplasm of the Extrahepatic Bile Duct|Benign Mesenchymal Tumor of Extrahepatic Bile Duct|Benign Mesenchymal Tumor of the Extrahepatic Bile Duct
C5857	Extrahepatic_Bile_Duct_Adenoma	Bile_Duct_Adenoma|Extrahepatic_Bile_Duct_Neoplasm	Extrahepatic Bile Duct Adenoma|Adenoma of Extrahepatic Bile Duct|Adenoma of the Extrahepatic Bile Duct
C5858	Hepatic_Inflammatory_Pseudotumor	Benign_Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Hepatic_Disorder	Hepatic Inflammatory Pseudotumor|Inflammatory Pseudotumor of Liver|Inflammatory Pseudotumor of the Liver|Liver Inflammatory Pseudotumor
C5859	Perihilar_Extrahepatic_Bile_Duct_Carcinoma	Extrahepatic_Bile_Duct_Carcinoma	Perihilar Extrahepatic Bile Duct Carcinoma
C5860	Bile_Duct_Rhabdomyosarcoma	Bile_Duct_Sarcoma|Rhabdomyosarcoma	Bile Duct Rhabdomyosarcoma|Rhabdomyosarcoma of Bile Duct|Rhabdomyosarcoma of the Bile Duct
C5861	Extrahepatic_Bile_Duct_Carcinoid_Tumor	Foregut_Carcinoid_Tumor|Malignant_Extrahepatic_Bile_Duct_Neoplasm	Extrahepatic Bile Duct Carcinoid Tumor|Carcinoid Neoplasm of Extrahepatic Bile Duct|Carcinoid Neoplasm of the Extrahepatic Bile Duct|Carcinoid Tumor of Extrahepatic Bile Duct|Carcinoid Tumor of the Extrahepatic Bile Duct|Extrahepatic Bile Duct Carcinoid Neoplasm
C5862	Bile_Duct_Mucoepidermoid_Carcinoma	Extrahepatic_Bile_Duct_Carcinoma|Mucoepidermoid_Carcinoma	Bile Duct Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Bile Duct|Mucoepidermoid Carcinoma of the Bile Duct
C5863	Stage_IVA_Oral_Cavity_Adenoid_Cystic_Carcinoma	Stage_IVA_Oral_Cavity_Carcinoma|Stage_IV_Oral_Cavity_Adenoid_Cystic_Carcinoma	Stage IVA Oral Cavity Adenoid Cystic Carcinoma|Stage IVA Adenoid Cystic Carcinoma of Mouth|Stage IVA Adenoid Cystic Carcinoma of Oral Cavity|Stage IVA Adenoid Cystic Carcinoma of the Mouth|Stage IVA Adenoid Cystic Carcinoma of the Oral Cavity|Stage IVA Mouth Adenoid Cystic Carcinoma
C5864	Stage_IVB_Oral_Cavity_Adenoid_Cystic_Carcinoma	Stage_IVB_Oral_Cavity_Carcinoma|Stage_IV_Oral_Cavity_Adenoid_Cystic_Carcinoma	Stage IVB Oral Cavity Adenoid Cystic Carcinoma|Stage IVB Adenoid Cystic Carcinoma of Mouth|Stage IVB Adenoid Cystic Carcinoma of Oral Cavity|Stage IVB Adenoid Cystic Carcinoma of the Mouth|Stage IVB Adenoid Cystic Carcinoma of the Oral Cavity|Stage IVB Mouth Adenoid Cystic Carcinoma
C5865	Stage_IVC_Oral_Cavity_Adenoid_Cystic_Carcinoma	Stage_IVC_Oral_Cavity_Carcinoma|Stage_IV_Oral_Cavity_Adenoid_Cystic_Carcinoma	Stage IVC Oral Cavity Adenoid Cystic Carcinoma|Stage IVC Adenoid Cystic Carcinoma of Mouth|Stage IVC Adenoid Cystic Carcinoma of Oral Cavity|Stage IVC Adenoid Cystic Carcinoma of the Mouth|Stage IVC Adenoid Cystic Carcinoma of the Oral Cavity|Stage IVC Mouth Adenoid Cystic Carcinoma
C5866	Stage_IVC_Oral_Cavity_Mucoepidermoid_Carcinoma	Stage_IVC_Oral_Cavity_Carcinoma|Stage_IV_Oral_Cavity_Mucoepidermoid_Carcinoma	Stage IVC Oral Cavity Mucoepidermoid Carcinoma|Stage IVC Mouth Mucoepidermoid Carcinoma|Stage IVC Mucoepidermoid Carcinoma of Mouth|Stage IVC Mucoepidermoid Carcinoma of Oral Cavity|Stage IVC Mucoepidermoid Carcinoma of the Mouth|Stage IVC Mucoepidermoid Carcinoma of the Oral Cavity
C5867	Stage_IVB_Oral_Cavity_Mucoepidermoid_Carcinoma	Stage_IVB_Oral_Cavity_Carcinoma|Stage_IV_Oral_Cavity_Mucoepidermoid_Carcinoma	Stage IVB Oral Cavity Mucoepidermoid Carcinoma|Stage IVB Mouth Mucoepidermoid Carcinoma|Stage IVB Mucoepidermoid Carcinoma of Mouth|Stage IVB Mucoepidermoid Carcinoma of Oral Cavity|Stage IVB Mucoepidermoid Carcinoma of the Mouth|Stage IVB Mucoepidermoid Carcinoma of the Oral Cavity
C5868	Stage_IVA_Oral_Cavity_Mucoepidermoid_Carcinoma	Stage_IVA_Oral_Cavity_Carcinoma|Stage_IV_Oral_Cavity_Mucoepidermoid_Carcinoma	Stage IVA Oral Cavity Mucoepidermoid Carcinoma|Stage IVA Mouth Mucoepidermoid Carcinoma|Stage IVA Mucoepidermoid Carcinoma of Mouth|Stage IVA Mucoepidermoid Carcinoma of Oral Cavity|Stage IVA Mucoepidermoid Carcinoma of the Mouth|Stage IVA Mucoepidermoid Carcinoma of the Oral Cavity
C5869	Stage_IVA_Oral_Cavity_Verrucous_Carcinoma	Stage_IVA_Oral_Cavity_Squamous_Cell_Carcinoma|Stage_IV_Oral_Cavity_Verrucous_Carcinoma	Stage IVA Oral Cavity Verrucous Carcinoma|Stage IVA Mouth Verrucous Carcinoma|Stage IVA Verrucous Carcinoma of Mouth|Stage IVA Verrucous Carcinoma of Oral Cavity|Stage IVA Verrucous Carcinoma of the Mouth|Stage IVA Verrucous Carcinoma of the Oral Cavity
C5870	Stage_IVB_Oral_Cavity_Verrucous_Carcinoma	Stage_IVB_Oral_Cavity_Squamous_Cell_Carcinoma|Stage_IV_Oral_Cavity_Verrucous_Carcinoma	Stage IVB Oral Cavity Verrucous Carcinoma|Stage IVB Mouth Verrucous Carcinoma|Stage IVB Verrucous Carcinoma of Mouth|Stage IVB Verrucous Carcinoma of Oral Cavity|Stage IVB Verrucous Carcinoma of the Mouth|Stage IVB Verrucous Carcinoma of the Oral Cavity
C5871	Stage_IVC_Oral_Cavity_Verrucous_Carcinoma	Stage_IVC_Oral_Cavity_Squamous_Cell_Carcinoma|Stage_IV_Oral_Cavity_Verrucous_Carcinoma	Stage IVC Oral Cavity Verrucous Carcinoma|Stage IVC Mouth Verrucous Carcinoma|Stage IVC Verrucous Carcinoma of Mouth|Stage IVC Verrucous Carcinoma of Oral Cavity|Stage IVC Verrucous Carcinoma of the Mouth|Stage IVC Verrucous Carcinoma of the Oral Cavity
C5872	Stage_IVC_Basal_Cell_Lip_Carcinoma	Stage_IVC_Lip_Carcinoma|Stage_IV_Lip_Basal_Cell_Carcinoma	Stage IVC Basal Cell Lip Carcinoma|Stage IVC Basal Cell Carcinoma of Lip|Stage IVC Basal Cell Carcinoma of the Lip
C5873	Stage_IVB_Basal_Cell_Lip_Carcinoma	Stage_IVB_Lip_Carcinoma|Stage_IV_Lip_Basal_Cell_Carcinoma	Stage IVB Basal Cell Lip Carcinoma|Stage IVB Basal Cell Carcinoma of Lip|Stage IVB Basal Cell Carcinoma of the Lip
C5874	Stage_IVA_Basal_Cell_Lip_Carcinoma	Stage_IVA_Lip_Carcinoma|Stage_IV_Lip_Basal_Cell_Carcinoma	Stage IVA Basal Cell Lip Carcinoma|Stage IVA Basal Cell Carcinoma of Lip|Stage IVA Basal Cell Carcinoma of the Lip
C5876	Stage_I_Lip_Cancer	Lip_Carcinoma	Stage I Lip Cancer|Stage I Cancer of Lip|Stage I Cancer of the Lip|Stage I Carcinoma of Lip|Stage I Carcinoma of the Lip|Stage I Lip Carcinoma
C5877	Stage_II_Lip_Cancer	Lip_Carcinoma	Stage II Lip Cancer|Stage II Cancer of Lip|Stage II Cancer of the Lip|Stage II Carcinoma of Lip|Stage II Carcinoma of the Lip|Stage II Lip Carcinoma
C5878	Stage_III_Lip_Cancer	Lip_Carcinoma	Stage III Lip Cancer|Stage III Cancer of Lip|Stage III Cancer of the Lip|Stage III Carcinoma of Lip|Stage III Carcinoma of the Lip|Stage III Lip Carcinoma
C5879	Stage_IV_Lip_Cancer	Lip_Carcinoma	Stage IV Lip Cancer|Stage IV Cancer of Lip|Stage IV Cancer of the Lip|Stage IV Carcinoma of Lip|Stage IV Carcinoma of the Lip|Stage IV Lip Carcinoma
C5880	Stage_IVA_Lip_Carcinoma	Stage_IV_Lip_Cancer	Stage IVA Lip Carcinoma|Stage IVA Carcinoma of Lip|Stage IVA Carcinoma of the Lip
C5881	Stage_IVB_Lip_Carcinoma	Stage_IV_Lip_Cancer	Stage IVB Lip Carcinoma|Stage IVB Carcinoma of Lip|Stage IVB Carcinoma of the Lip
C5882	Stage_IVC_Lip_Carcinoma	Stage_IV_Lip_Cancer	Stage IVC Lip Carcinoma|Stage IVC Carcinoma of Lip|Stage IVC Carcinoma of the Lip
C5883	Stage_I_Oral_Cavity_Carcinoma	Oral_Cavity_Carcinoma	Stage I Oral Cavity Carcinoma|Stage I Carcinoma of Mouth|Stage I Carcinoma of Oral Cavity|Stage I Carcinoma of the Mouth|Stage I Carcinoma of the Oral Cavity|Stage I Mouth Carcinoma
C5884	Stage_II_Oral_Cavity_Carcinoma	Oral_Cavity_Carcinoma	Stage II Oral Cavity Carcinoma|Stage II Carcinoma of Mouth|Stage II Carcinoma of Oral Cavity|Stage II Carcinoma of the Mouth|Stage II Carcinoma of the Oral Cavity|Stage II Mouth Carcinoma
C5885	Stage_III_Oral_Cavity_Carcinoma	Oral_Cavity_Carcinoma	Stage III Oral Cavity Carcinoma|Stage III Carcinoma of Mouth|Stage III Carcinoma of Oral Cavity|Stage III Carcinoma of the Mouth|Stage III Carcinoma of the Oral Cavity|Stage III Mouth Carcinoma
C5886	Stage_IV_Oral_Cavity_Carcinoma	Oral_Cavity_Carcinoma	Stage IV Oral Cavity Carcinoma|Stage IV Carcinoma of Mouth|Stage IV Carcinoma of Oral Cavity|Stage IV Carcinoma of the Mouth|Stage IV Carcinoma of the Oral Cavity|Stage IV Mouth Carcinoma
C5887	Stage_IVA_Oral_Cavity_Carcinoma	Stage_IV_Oral_Cavity_Carcinoma	Stage IVA Oral Cavity Carcinoma|Stage IVA Carcinoma of Mouth|Stage IVA Carcinoma of Oral Cavity|Stage IVA Carcinoma of the Mouth|Stage IVA Carcinoma of the Oral Cavity|Stage IVA Mouth Carcinoma
C5888	Stage_IVB_Oral_Cavity_Carcinoma	Stage_IV_Oral_Cavity_Carcinoma	Stage IVB Oral Cavity Carcinoma|Stage IVB Carcinoma of Mouth|Stage IVB Carcinoma of Oral Cavity|Stage IVB Carcinoma of the Mouth|Stage IVB Carcinoma of the Oral Cavity|Stage IVB Mouth Carcinoma
C5889	Stage_IVC_Oral_Cavity_Carcinoma	Stage_IV_Oral_Cavity_Carcinoma	Stage IVC Oral Cavity Carcinoma|Stage IVC Carcinoma of Mouth|Stage IVC Carcinoma of Oral Cavity|Stage IVC Carcinoma of the Mouth|Stage IVC Carcinoma of the Oral Cavity|Stage IVC Mouth Carcinoma
C5892	Stage_0_Oral_Cavity_Verrucous_Carcinoma	Oral_Cavity_Verrucous_Carcinoma|Stage_0_Oral_Cavity_Squamous_Cell_Carcinoma	Stage 0 Oral Cavity Verrucous Carcinoma|Mouth Verrucous Carcinoma in situ|Oral Cavity Verrucous Carcinoma in situ|Stage 0 Mouth Verrucous Carcinoma|Stage 0 Verrucous Carcinoma of Mouth|Stage 0 Verrucous Carcinoma of Oral Cavity|Stage 0 Verrucous Carcinoma of the Mouth|Stage 0 Verrucous Carcinoma of the Oral Cavity|Verrucous Carcinoma in situ of Mouth|Verrucous Carcinoma in situ of Oral Cavity|Verrucous Carcinoma in situ of the Mouth|Verrucous Carcinoma in situ of the Oral Cavity
C5893	Stage_0_Lip_Basal_Cell_Carcinoma	Lip_Basal_Cell_Carcinoma	Stage 0 Lip Basal Cell Carcinoma|Basal Cell Carcinoma in situ of Lip|Basal Cell Carcinoma in situ of the Lip|Lip Basal Cell Carcinoma in situ|Stage 0 Basal Cell Carcinoma of Lip|Stage 0 Basal Cell Carcinoma of the Lip
C5895	Stage_I_Major_Salivary_Gland_Carcinoma	Major_Salivary_Gland_Carcinoma	Stage I Major Salivary Gland Carcinoma|Stage I Carcinoma of Major Salivary Gland|Stage I Carcinoma of the Major Salivary Gland|Stage I Major Salivary Gland Cancer|Stage I Salivary Gland Cancer|Stage I Salivary Gland Carcinoma
C5896	Stage_II_Major_Salivary_Gland_Carcinoma	Major_Salivary_Gland_Carcinoma	Stage II Major Salivary Gland Carcinoma|Stage II Carcinoma of Major Salivary Gland|Stage II Carcinoma of the Major Salivary Gland|Stage II Major Salivary Gland Cancer|Stage II Salivary Gland Cancer|Stage II Salivary Gland Carcinoma
C5897	Stage_III_Major_Salivary_Gland_Carcinoma	Major_Salivary_Gland_Carcinoma	Stage III Major Salivary Gland Carcinoma|Stage III Carcinoma of Major Salivary Gland|Stage III Carcinoma of the Major Salivary Gland|Stage III Major Salivary Gland Cancer|Stage III Salivary Gland Cancer
C5898	Stage_IV_Major_Salivary_Gland_Carcinoma	Major_Salivary_Gland_Carcinoma	Stage IV Major Salivary Gland Carcinoma|Stage IV Carcinoma of Major Salivary Gland|Stage IV Carcinoma of the Major Salivary Gland|Stage IV Major Salivary Gland Cancer|Stage IV Salivary Gland Cancer
C5899	Stage_IV_Major_Salivary_Gland_Carcinoma_with_Metastasis	Stage_IV_Major_Salivary_Gland_Carcinoma	Stage IV Major Salivary Gland Carcinoma with Metastasis|Stage IV Carcinoma of Major Salivary Gland with Metastasis|Stage IV Carcinoma of the Major Salivary Gland with Metastasis
C5900	Stage_IV_Major_Salivary_Gland_Carcinoma_without_Metastasis	Stage_IV_Major_Salivary_Gland_Carcinoma	Stage IV Major Salivary Gland Carcinoma without Metastasis|Stage IV Carcinoma of Major Salivary Gland without Metastasis|Stage IV Carcinoma of the Major Salivary Gland without Metastasis
C5901	Major_Salivary_Gland_Acinic_Cell_Carcinoma	Major_Salivary_Gland_Adenocarcinoma|Salivary_Gland_Acinic_Cell_Carcinoma	Major Salivary Gland Acinic Cell Carcinoma|Acinic Cell Adenocarcinoma of Major Salivary Gland|Acinic Cell Adenocarcinoma of the Major Salivary Gland|Acinic Cell Carcinoma of Major Salivary Gland|Acinic Cell Carcinoma of the Major Salivary Gland|Major Salivary Gland Acinic Cell Adenocarcinoma
C5902	Malignant_Mixed_Tumor_of_the_Major_Salivary_Gland	Malignant_Major_Salivary_Gland_Neoplasm|Malignant_Mixed_Tumor_of_the_Salivary_Gland	Malignant Mixed Tumor of the Major Salivary Gland|Malignant Major Salivary Gland Mixed Neoplasm|Malignant Major Salivary Gland Mixed Tumor|Malignant Mixed Neoplasm of Major Salivary Gland|Malignant Mixed Neoplasm of the Major Salivary Gland|Malignant Mixed Tumor of Major Salivary Gland
C5903	Major_Salivary_Gland_Adenocarcinoma	Major_Salivary_Gland_Carcinoma|Salivary_Gland_Adenocarcinoma	Major Salivary Gland Adenocarcinoma|Adenocarcinoma of Major Salivary Gland|Adenocarcinoma of the Major Salivary Gland
C5904	Salivary_Duct_Carcinoma	Salivary_Gland_Adenocarcinoma	Salivary Duct Carcinoma|Carcinoma of Salivary Duct|Carcinoma of the Salivary Duct
C5905	Major_Salivary_Gland_Adenoid_Cystic_Carcinoma	Major_Salivary_Gland_Carcinoma|Salivary_Gland_Adenoid_Cystic_Carcinoma	Major Salivary Gland Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Major Salivary Gland|Adenoid Cystic Carcinoma of the Major Salivary Gland
C5906	Major_Salivary_Gland_Mucoepidermoid_Carcinoma	Major_Salivary_Gland_Carcinoma|Salivary_Gland_Mucoepidermoid_Carcinoma	Major Salivary Gland Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Major Salivary Gland|Mucoepidermoid Carcinoma of the Major Salivary Gland	Mucoepidermoid carcinomas are the most frequent malignancy in major salivary glands, especially the parotid gland.
C5907	Major_Salivary_Gland_Carcinoma	Malignant_Major_Salivary_Gland_Neoplasm|Salivary_Gland_Carcinoma	Major Salivary Gland Carcinoma|Carcinoma of Major Salivary Gland|Carcinoma of the Major Salivary Gland
C5908	Salivary_Gland_Mucoepidermoid_Carcinoma	Mucoepidermoid_Carcinoma|Salivary_Gland_Carcinoma	Salivary Gland Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Salivary Gland|Mucoepidermoid Carcinoma of the Salivary Gland
C5909	Oral_Cavity_Leiomyoma	Benign_Oral_Cavity_Neoplasm|Leiomyoma	Oral Cavity Leiomyoma|Leiomyoma of Mouth|Leiomyoma of Oral Cavity|Leiomyoma of the Mouth|Leiomyoma of the Oral Cavity|Mouth Leiomyoma
C5910	Oral_Cavity_Lipoma	Benign_Oral_Cavity_Neoplasm|Lipoma	Oral Cavity Lipoma|Lipoma of Mouth|Lipoma of Oral Cavity|Lipoma of the Mouth|Lipoma of the Oral Cavity|Mouth Lipoma
C5912	Oral_Cavity_Granular_Cell_Tumor	Granular_Cell_Tumor|Oral_Cavity_Neoplasm	Oral Cavity Granular Cell Tumor|Granular Cell Neoplasm of Mouth|Granular Cell Neoplasm of Oral Cavity|Granular Cell Neoplasm of the Mouth|Granular Cell Neoplasm of the Oral Cavity|Granular Cell Tumor of Mouth|Granular Cell Tumor of Oral Cavity|Granular Cell Tumor of the Mouth|Granular Cell Tumor of the Oral Cavity|Mouth Granular Cell Neoplasm|Mouth Granular Cell Tumor|Oral Cavity Granular Cell Neoplasm
C5913	Oral_Cavity_Adenoma	Adenoma|Benign_Oral_Cavity_Neoplasm	Oral Cavity Adenoma|Adenoma of Mouth|Adenoma of Oral Cavity|Adenoma of the Mouth|Adenoma of the Oral Cavity|Mouth Adenoma
C5914	Oral_Cavity_Adenocarcinoma	Adenocarcinoma|Oral_Cavity_Carcinoma	Oral Cavity Adenocarcinoma|Adenocarcinoma of Mouth|Adenocarcinoma of Oral Cavity|Adenocarcinoma of the Mouth|Adenocarcinoma of the Oral Cavity|Mouth Adenocarcinoma
C5915	Oral_Cavity_Mucosal_Melanoma	Malignant_Oral_Cavity_Neoplasm|Non-Cutaneous_Melanoma	Oral Cavity Mucosal Melanoma|Mouth Mucosal Melanoma|Mucosal Melanoma of Mouth|Mucosal Melanoma of Oral Cavity|Mucosal Melanoma of the Mouth|Mucosal Melanoma of the Oral Cavity
C5916	Oral_Cavity_Sarcoma	Malignant_Oral_Cavity_Neoplasm|Soft_Tissue_Sarcoma	Oral Cavity Sarcoma|Mouth Sarcoma|Sarcoma of Mouth|Sarcoma of Oral Cavity|Sarcoma of the Mouth|Sarcoma of the Oral Cavity
C5917	Upper_Gingival_Verrucous_Carcinoma	Oral_Cavity_Verrucous_Carcinoma|Upper_Gingival_Squamous_Cell_Carcinoma	Upper Gingival Verrucous Carcinoma|Upper Gum Verrucous Carcinoma|Verrucous Carcinoma of Upper Gingiva|Verrucous Carcinoma of Upper Gum|Verrucous Carcinoma of the Upper Gingiva|Verrucous Carcinoma of the Upper Gum
C5918	Tonsillar_Lymphoma	Lymphoma_by_Site|Malignant_Tonsillar_Neoplasm	Tonsillar Lymphoma|Lymphoma of Tonsil|Lymphoma of the Tonsil|Primary Tonsillar Lymphoma|Tonsil Lymphoma
C5919	Astler-Coller_B3_Colon_Carcinoma	Astler-Coller_B3_Colorectal_Carcinoma|Colon_Cancer_by_Astler-Coller_Stage	Astler-Coller B3 Colon Carcinoma|Astler-Coller B3 Carcinoma of Colon|Astler-Coller B3 Carcinoma of the Colon|Astler-Coller B3 Colonic Carcinoma	Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.) - 2003
C5920	Astler-Coller_B3_Rectal_Carcinoma	Astler-Coller_B3_Colorectal_Carcinoma|Rectal_Cancer_by_Astler-Coller_Stage	Astler-Coller B3 Rectal Carcinoma|Astler-Coller B3 Carcinoma of Rectum|Astler-Coller B3 Carcinoma of the Rectum	Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.) - 2003
C5921	Astler-Coller_C3_Rectal_Carcinoma	Astler-Coller_C3_Colorectal_Carcinoma|Rectal_Cancer_by_Astler-Coller_Stage	Astler-Coller C3 Rectal Carcinoma|Astler-Coller C3 Carcinoma of Rectum|Astler-Coller C3 Carcinoma of the Rectum
C5922	Astler-Coller_C1_Rectal_Carcinoma	Astler-Coller_C1_Colorectal_Carcinoma|Rectal_Cancer_by_Astler-Coller_Stage	Astler-Coller C1 Rectal Carcinoma|Astler-Coller C1 Carcinoma of Rectum|Astler-Coller C1 Carcinoma of the Rectum	Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.) - 2003
C5923	Astler-Coller_C2_Rectal_Carcinoma	Astler-Coller_C2_Colorectal_Carcinoma|Rectal_Cancer_by_Astler-Coller_Stage	Astler-Coller C2 Rectal Carcinoma|Astler-Coller C2 Carcinoma of Rectum|Astler-Coller C2 Carcinoma of the Rectum	Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.) - 2003
C5924	Astler-Coller_A_Rectal_Carcinoma	Astler-Coller_A_Colorectal_Carcinoma|Rectal_Cancer_by_Astler-Coller_Stage	Astler-Coller A Rectal Carcinoma|Astler-Coller A Carcinoma of Rectum|Astler-Coller A Carcinoma of the Rectum	Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. (AJCC 6th ed.) -2003
C5925	Stage_IIIA_Anal_Cancer	Stage_III_Anal_Canal_Cancer	Stage IIIA Anal Cancer|Anal Cancer Stage IIIA|Stage IIIA Anal Carcinoma|Stage IIIA Carcinoma of Anus|Stage IIIA Carcinoma of the Anus|stage IIIA anal cancer	Cancer has spread to the lymph nodes around the rectum or to nearby organs such as the vagina or bladder.
C5926	Stage_IIIB_Anal_Cancer	Stage_III_Anal_Canal_Cancer	Stage IIIB Anal Cancer|Anal Cancer Stage IIIB|Stage IIIB Anal Carcinoma|Stage IIIB Carcinoma of Anus|Stage IIIB Carcinoma of the Anus|stage IIIB anal cancer	Cancer has spread to the lymph nodes in the middle of the abdomen or in the groin, or the cancer has spread to both nearby organs and the lymph nodes around the rectum.
C5927	Astler-Coller_A_Colorectal_Carcinoma	Colorectal_Cancer_by_Astler-Coller_Stage	Astler-Coller A Colorectal Carcinoma
C5928	Astler-Coller_B3_Colorectal_Carcinoma	Colorectal_Cancer_by_Astler-Coller_Stage	Astler-Coller B3 Colorectal Carcinoma
C5929	Astler-Coller_C3_Colorectal_Carcinoma	Colorectal_Cancer_by_Astler-Coller_Stage	Astler-Coller C3 Colorectal Carcinoma
C5930	Astler-Coller_C2_Colorectal_Carcinoma	Colorectal_Cancer_by_Astler-Coller_Stage	Astler-Coller C2 Colorectal Carcinoma
C5931	Astler-Coller_C1_Colorectal_Carcinoma	Colorectal_Cancer_by_Astler-Coller_Stage	Astler-Coller C1 Colorectal Carcinoma
C5932	Salivary_Gland_Oncocytoma	Salivary_Gland_Monomorphic_Adenoma	Salivary Gland Oncocytoma|Oncocytoma of Salivary Gland|Oncocytoma of the Salivary Gland|Oxyphilic Adenoma of Salivary Gland|Oxyphilic Adenoma of the Salivary Gland|Salivary Gland Oxyphilic Adenoma	A rare benign epithelial neoplasm composed of oncocytes, which are large cells with a large amount of granular eosinophilic cytoplasm containing numerous tightly-packed mitochondria.  Approximately 85% to 90% occur in the parotid gland; most of the remainder occur in the submandibular gland. The peak incidence is in the seventh through ninth decades of life. In almost all cases, swelling is the only complaint of the patient.  -- 2003
C5933	Parotid_Gland_Acinic_Cell_Carcinoma	Major_Salivary_Gland_Acinic_Cell_Carcinoma|Parotid_Gland_Adenocarcinoma	Parotid Gland Acinic Cell Carcinoma|Acinic Cell Carcinoma of Parotid|Acinic Cell Carcinoma of Parotid Gland|Acinic Cell Carcinoma of the Parotid|Acinic Cell Carcinoma of the Parotid Gland|Parotid Acinic Cell Carcinoma
C5934	Submandibular_Gland_Acinic_Cell_Carcinoma	Major_Salivary_Gland_Acinic_Cell_Carcinoma|Submandibular_Gland_Adenocarcinoma	Submandibular Gland Acinic Cell Carcinoma|Acinic Cell Carcinoma of Submandibular Gland|Acinic Cell Carcinoma of Submaxillary Gland|Acinic Cell Carcinoma of the Submandibular Gland|Acinic Cell Carcinoma of the Submaxillary Gland|Submaxillary Gland Acinic Cell Carcinoma
C5935	Submandibular_Gland_Adenoid_Cystic_Carcinoma	Major_Salivary_Gland_Adenoid_Cystic_Carcinoma|Submandibular_Gland_Carcinoma	Submandibular Gland Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Submandibular Gland|Adenoid Cystic Carcinoma of the Submandibular Gland
C5936	Minor_Salivary_Gland_Adenoid_Cystic_Carcinoma	Minor_Salivary_Gland_Carcinoma|Salivary_Gland_Adenoid_Cystic_Carcinoma	Minor Salivary Gland Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Minor Salivary Gland|Adenoid Cystic Carcinoma of the Minor Salivary Gland
C5937	Parotid_Gland_Adenoid_Cystic_Carcinoma	Major_Salivary_Gland_Adenoid_Cystic_Carcinoma|Parotid_Gland_Carcinoma	Parotid Gland Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Parotid|Adenoid Cystic Carcinoma of Parotid Gland|Adenoid Cystic Carcinoma of the Parotid|Adenoid Cystic Carcinoma of the Parotid Gland|Parotid Adenoid Cystic Carcinoma
C5938	Parotid_Gland_Mucoepidermoid_Carcinoma	Major_Salivary_Gland_Mucoepidermoid_Carcinoma|Parotid_Gland_Carcinoma	Parotid Gland Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Parotid|Mucoepidermoid Carcinoma of Parotid Gland|Mucoepidermoid Carcinoma of the Parotid|Mucoepidermoid Carcinoma of the Parotid Gland|Parotid Mucoepidermoid Carcinoma
C5939	Submandibular_Gland_Mucoepidermoid_Carcinoma	Major_Salivary_Gland_Mucoepidermoid_Carcinoma|Submandibular_Gland_Carcinoma	Submandibular Gland Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Submandibular Gland|Mucoepidermoid Carcinoma of the Submandibular Gland
C5940	Submandibular_Gland_Adenocarcinoma	Major_Salivary_Gland_Adenocarcinoma|Submandibular_Gland_Carcinoma	Submandibular Gland Adenocarcinoma|Adenocarcinoma of Submandibular Gland|Adenocarcinoma of the Submandibular Gland
C5941	Parotid_Gland_Adenocarcinoma	Major_Salivary_Gland_Adenocarcinoma|Parotid_Gland_Carcinoma	Parotid Gland Adenocarcinoma|Adenocarcinoma of Parotid|Adenocarcinoma of Parotid Gland|Adenocarcinoma of the Parotid|Adenocarcinoma of the Parotid Gland|Parotid Adenocarcinoma
C5942	Parotid_Gland_Squamous_Cell_Carcinoma	Parotid_Gland_Carcinoma|Salivary_Gland_Squamous_Cell_Carcinoma	Parotid Gland Squamous Cell Carcinoma|Parotid Squamous Cell Carcinoma|Squamous Cell Carcinoma of Parotid|Squamous Cell Carcinoma of Parotid Gland|Squamous Cell Carcinoma of the Parotid|Squamous Cell Carcinoma of the Parotid Gland
C5943	Submandibular_Gland_Squamous_Cell_Carcinoma	Salivary_Gland_Squamous_Cell_Carcinoma|Submandibular_Gland_Carcinoma	Submandibular Gland Squamous Cell Carcinoma|Squamous Cell Carcinoma of Submandibular Gland|Squamous Cell Carcinoma of the Submandibular Gland
C5944	Malignant_Submandibular_Gland_Mixed_Tumor	Malignant_Mixed_Tumor_of_the_Major_Salivary_Gland|Malignant_Submandibular_Gland_Neoplasm	Malignant Submandibular Gland Mixed Tumor|Malignant Mixed Neoplasm of Submandibular Gland|Malignant Mixed Neoplasm of the Submandibular Gland|Malignant Mixed Tumor of Submandibular Gland|Malignant Mixed Tumor of the Submandibular Gland|Malignant Submandibular Gland Mixed Neoplasm
C5945	Malignant_Parotid_Gland_Mixed_Tumor	Malignant_Mixed_Tumor_of_the_Major_Salivary_Gland|Malignant_Parotid_Gland_Neoplasm|Mixed_Tumor_of_the_Parotid_Gland	Malignant Parotid Gland Mixed Tumor|Malignant Mixed Neoplasm of Parotid|Malignant Mixed Neoplasm of Parotid Gland|Malignant Mixed Neoplasm of the Parotid|Malignant Mixed Neoplasm of the Parotid Gland|Malignant Mixed Tumor of Parotid|Malignant Mixed Tumor of Parotid Gland|Malignant Mixed Tumor of the Parotid|Malignant Mixed Tumor of the Parotid Gland|Malignant Parotid Gland Mixed Neoplasm|Malignant Parotid Mixed Neoplasm|Malignant Parotid Mixed Tumor
C5946	Undifferentiated_Parotid_Gland_Carcinoma	Parotid_Gland_Carcinoma|Undifferentiated_Carcinoma|Undifferentiated_Salivary_Gland_Carcinoma	Undifferentiated Parotid Gland Carcinoma|Anaplastic Carcinoma of Parotid|Anaplastic Carcinoma of Parotid Gland|Anaplastic Carcinoma of the Parotid|Anaplastic Carcinoma of the Parotid Gland|Anaplastic Parotid Carcinoma|Anaplastic Parotid Gland Carcinoma|Parotid Gland Undifferentiated Carcinoma|Undifferentiated Carcinoma of Parotid|Undifferentiated Carcinoma of Parotid Gland|Undifferentiated Carcinoma of the Parotid|Undifferentiated Carcinoma of the Parotid Gland
C5947	Submandibular_Gland_Undifferentiated_Carcinoma	Submandibular_Gland_Carcinoma|Undifferentiated_Salivary_Gland_Carcinoma	Submandibular Gland Undifferentiated Carcinoma|Anaplastic Carcinoma of Submandibular Gland|Anaplastic Carcinoma of the Submandibular Gland|Undifferentiated Carcinoma of Submandibular Gland|Undifferentiated Carcinoma of the Submandibular Gland
C5948	Minor_Salivary_Gland_Adenocarcinoma	Minor_Salivary_Gland_Carcinoma|Salivary_Gland_Adenocarcinoma	Minor Salivary Gland Adenocarcinoma|Adenocarcinoma of Minor Salivary Gland|Adenocarcinoma of the Minor Salivary Gland
C5949	Parotid_Gland_Sebaceous_Lymphadenoma	Parotid_Gland_Monomorphic_Adenoma|Salivary_Gland_Sebaceous_Lymphadenoma	Parotid Gland Sebaceous Lymphadenoma|Sebaceous Lymphadenoma of the Parotid Gland
C5950	Salivary_Gland_Basal_Cell_Adenoma	Benign_Basal_Cell_Neoplasm|Salivary_Gland_Monomorphic_Adenoma	Salivary Gland Basal Cell Adenoma|Basal Cell Adenoma|Basal Cell Adenoma of Salivary Gland|Basal Cell Adenoma of the Salivary Gland	A benign epithelial neoplasm with a uniform, monomorphic appearance that is dominated by basal cells forming trabecular structures. It is rare, and occurs mostly on the parotid gland. The average age of patients has been reported to be 58 years. Swelling is the most constant clinical finding. -- 2003
C5951	Parotid_Gland_Non-Hodgkin_s_Lymphoma	Major_Salivary_Gland_Non-Hodgkin_s_Lymphoma|Malignant_Parotid_Gland_Neoplasm	Parotid Gland Non-Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma of Parotid|Non-Hodgkin's Lymphoma of Parotid Gland|Non-Hodgkin's Lymphoma of the Parotid|Non-Hodgkin's Lymphoma of the Parotid Gland|Parotid Gland Non-Hodgkin Lymphoma|Parotid Non-Hodgkin's Lymphoma|Primary Parotid Gland Non-Hodgkin's Lymphoma
C5952	Parotid_Gland_Kaposi_s_Sarcoma	Kaposi_s_Sarcoma|Major_Salivary_Gland_Sarcoma|Malignant_Parotid_Gland_Neoplasm	Parotid Gland Kaposi's Sarcoma|Kaposi's Sarcoma of Parotid|Kaposi's Sarcoma of Parotid Gland|Kaposi's Sarcoma of the Parotid|Kaposi's Sarcoma of the Parotid Gland|Parotid Kaposi's Sarcoma
C5953	Minor_Salivary_Gland_Mucoepidermoid_Carcinoma	Minor_Salivary_Gland_Carcinoma|Salivary_Gland_Mucoepidermoid_Carcinoma	Minor Salivary Gland Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Minor Salivary Gland|Mucoepidermoid Carcinoma of the Minor Salivary Gland
C5954	Minor_Salivary_Gland_Undifferentiated_Carcinoma	Minor_Salivary_Gland_Carcinoma|Undifferentiated_Salivary_Gland_Carcinoma	Minor Salivary Gland Undifferentiated Carcinoma|Anaplastic Carcinoma of Minor Salivary Gland|Anaplastic Carcinoma of the Minor Salivary Gland|Anaplastic Minor Salivary Gland Carcinoma|Undifferentiated Carcinoma of Minor Salivary Gland|Undifferentiated Carcinoma of the Minor Salivary Gland
C5955	Malignant_Mixed_Tumor_of_the_Minor_Salivary_Gland	Malignant_Minor_Salivary_Gland_Neoplasm|Malignant_Mixed_Tumor_of_the_Salivary_Gland	Malignant Mixed Tumor of the Minor Salivary Gland|Malignant Minor Salivary Gland Mixed Neoplasm|Malignant Minor Salivary Gland Mixed Tumor|Malignant Mixed Neoplasm of Minor Salivary Gland|Malignant Mixed Neoplasm of the Minor Salivary Gland|Malignant Mixed Tumor of Minor Salivary Gland
C5956	Minor_Salivary_Gland_Anaplastic_Small_Cell_Carcinoma	Minor_Salivary_Gland_Carcinoma|Salivary_Gland_Anaplastic_Small_Cell_Carcinoma	Minor Salivary Gland Anaplastic Small Cell Carcinoma|Anaplastic Small Cell Carcinoma of Minor Salivary Gland|Anaplastic Small Cell Carcinoma of the Minor Salivary Gland|Minor Salivary Gland Neuroendocrine Carcinoma|Minor Salivary Gland Oat Cell Carcinoma|Neuroendocrine Carcinoma of Minor Salivary Gland|Neuroendocrine Carcinoma of the Minor Salivary Gland|Oat Cell Carcinoma of Minor Salivary Gland|Oat Cell Carcinoma of the Minor Salivary Gland
C5957	Minor_Salivary_Gland_Carcinoma	Malignant_Minor_Salivary_Gland_Neoplasm|Salivary_Gland_Carcinoma	Minor Salivary Gland Carcinoma|Carcinoma of Minor Salivary Gland|Carcinoma of the Minor Salivary Gland
C5958	Sublingual_Gland_Adenocarcinoma	Major_Salivary_Gland_Adenocarcinoma|Sublingual_Gland_Carcinoma	Sublingual Gland Adenocarcinoma|Adenocarcinoma of Sublingual Gland|Adenocarcinoma of the Sublingual Gland
C5959	Minor_Salivary_Gland_Squamous_Cell_Carcinoma	Salivary_Gland_Squamous_Cell_Carcinoma	Minor Salivary Gland Squamous Cell Carcinoma|Epidermoid Carcinoma of Minor Salivary Gland|Epidermoid Carcinoma of the Minor Salivary Gland|Minor Salivary Gland Epidermoid Carcinoma|Squamous Cell Carcinoma of Minor Salivary Gland|Squamous Cell Carcinoma of the Minor Salivary Gland
C5960	Childhood_Supratentorial_Neoplasm	Childhood_Brain_Neoplasm|Supratentorial_Neoplasm	Childhood Supratentorial Neoplasm|Childhood Supratentorial Neoplasms|Childhood Supratentorial Tumor|Childhood Supratentorial Tumors|Pediatric Supratentorial Neoplasm|Pediatric Supratentorial Tumor
C5961	Childhood_Central_Nervous_System_Primitive_Neuroectodermal_Tumor	Central_Nervous_System_Primitive_Neuroectodermal_Tumor|Malignant_Childhood_Central_Nervous_System_Neoplasm	Childhood Central Nervous System Primitive Neuroectodermal Tumor|Childhood CNS PNET|Childhood CNS Primitive Neuroectodermal Neoplasm|Childhood CNS Primitive Neuroectodermal Tumor|Childhood Central Nervous System PNET|Childhood Central Nervous System Primitive Neuroectodermal Neoplasm|Childhood Central Primitive Neuroectodermal Neoplasm|Childhood Central Primitive Neuroectodermal Tumor|Pediatric CNS PNET|Pediatric CNS Primitive Neuroectodermal Neoplasm|Pediatric CNS Primitive Neuroectodermal Tumor|Pediatric Central Nervous System Primitive Neuroectodermal Neoplasm|Pediatric Central Nervous System Primitive Neuroectodermal Tumor|Pediatric Central Primitive Neuroectodermal Neoplasm|Pediatric Central Primitive Neuroectodermal Tumor
C5962	Malignant_Prolactin_Producing_Pituitary_Gland_Neoplasm	Pituitary_Gland_Carcinoma|Prolactin_Producing_Pituitary_Gland_Neoplasm	Prolactin Producing Pituitary Gland Carcinoma|Malignant Pituitary Gland Prolactinoma|Malignant Pituitary Prolactinoma|Malignant Prolactin Producing Neoplasm of Pituitary|Malignant Prolactin Producing Neoplasm of Pituitary Gland|Malignant Prolactin Producing Neoplasm of the Pituitary|Malignant Prolactin Producing Neoplasm of the Pituitary Gland|Malignant Prolactin Producing Pituitary Gland Neoplasm|Malignant Prolactin Producing Pituitary Gland Tumor|Malignant Prolactin Producing Pituitary Neoplasm|Malignant Prolactin Producing Pituitary Tumor|Malignant Prolactin Producing Tumor|Malignant Prolactin Producing Tumor of Pituitary|Malignant Prolactin Producing Tumor of Pituitary Gland|Malignant Prolactin Producing Tumor of the Pituitary|Malignant Prolactin Producing Tumor of the Pituitary Gland|Malignant Prolactin Secreting Neoplasm of Pituitary|Malignant Prolactin Secreting Neoplasm of Pituitary Gland|Malignant Prolactin Secreting Neoplasm of the Pituitary|Malignant Prolactin Secreting Neoplasm of the Pituitary Gland|Malignant Prolactin Secreting Pituitary Gland Neoplasm|Malignant Prolactin Secreting Pituitary Gland Tumor|Malignant Prolactin Secreting Pituitary Neoplasm|Malignant Prolactin Secreting Pituitary Tumor|Malignant Prolactin Secreting Tumor of Pituitary|Malignant Prolactin Secreting Tumor of Pituitary Gland|Malignant Prolactin Secreting Tumor of the Pituitary|Malignant Prolactin Secreting Tumor of the Pituitary Gland|Malignant Prolactinoma|Malignant Prolactinoma of Pituitary|Malignant Prolactinoma of Pituitary Gland|Malignant Prolactinoma of the Pituitary|Malignant Prolactinoma of the Pituitary Gland|PRL Producing Pituitary Gland Carcinoma	A rare, hormonally functioning or non-functioning pituitary gland adenocarcinoma that produces prolactin. (NCI05)
C5963	Malignant_Growth_Hormone_Secreting_Pituitary_Neoplasm	Growth_Hormone_Secreting_Pituitary_Neoplasm|Pituitary_Gland_Carcinoma	Growth Hormone Producing Pituitary Gland Carcinoma|Malignant Growth Hormone Producing Neoplasm of Pituitary|Malignant Growth Hormone Producing Neoplasm of Pituitary Gland|Malignant Growth Hormone Producing Neoplasm of the Pituitary|Malignant Growth Hormone Producing Neoplasm of the Pituitary Gland|Malignant Growth Hormone Producing Pituitary Gland Neoplasm|Malignant Growth Hormone Producing Pituitary Gland Tumor|Malignant Growth Hormone Producing Pituitary Neoplasm|Malignant Growth Hormone Producing Pituitary Tumor|Malignant Growth Hormone Producing Tumor|Malignant Growth Hormone Producing Tumor of Pituitary|Malignant Growth Hormone Producing Tumor of Pituitary Gland|Malignant Growth Hormone Producing Tumor of the Pituitary|Malignant Growth Hormone Producing Tumor of the Pituitary Gland|Malignant Growth Hormone Secreting Neoplasm of Pituitary|Malignant Growth Hormone Secreting Neoplasm of Pituitary Gland|Malignant Growth Hormone Secreting Neoplasm of the Pituitary|Malignant Growth Hormone Secreting Neoplasm of the Pituitary Gland|Malignant Growth Hormone Secreting Pituitary Gland Neoplasm|Malignant Growth Hormone Secreting Pituitary Gland Tumor|Malignant Growth Hormone Secreting Pituitary Neoplasm|Malignant Growth Hormone Secreting Pituitary Tumor|Malignant Growth Hormone Secreting Tumor of Pituitary|Malignant Growth Hormone Secreting Tumor of Pituitary Gland|Malignant Growth Hormone Secreting Tumor of the Pituitary|Malignant Growth Hormone Secreting Tumor of the Pituitary Gland|Malignant Pituitary Gland Somatotropinoma|Malignant Pituitary Somatotropinoma|Malignant Somatotropinoma of Pituitary|Malignant Somatotropinoma of Pituitary Gland|Malignant Somatotropinoma of the Pituitary|Malignant Somatotropinoma of the Pituitary Gland	A rare, hormonally functioning or non-functioning pituitary gland adenocarcinoma that produces growth hormone.  It may be associated with acromegaly. (NCI05)
C5964	Malignant_ACTH_Producing_Pituitary_Gland_Neoplasm	Pituitary_Corticotropin_Secreting_Tumor|Pituitary_Gland_Carcinoma	ACTH Producing Pituitary Gland Carcinoma|Malignant ACTH Producing Neoplasm of Pituitary|Malignant ACTH Producing Neoplasm of Pituitary Gland|Malignant ACTH Producing Neoplasm of the Pituitary|Malignant ACTH Producing Neoplasm of the Pituitary Gland|Malignant ACTH Producing Pituitary Gland Neoplasm|Malignant ACTH Producing Pituitary Gland Tumor|Malignant ACTH Producing Pituitary Neoplasm|Malignant ACTH Producing Pituitary Tumor|Malignant ACTH Producing Tumor of Pituitary|Malignant ACTH Producing Tumor of Pituitary Gland|Malignant ACTH Producing Tumor of the Pituitary|Malignant ACTH Producing Tumor of the Pituitary Gland|Malignant ACTH Secreting Neoplasm of Pituitary|Malignant ACTH Secreting Neoplasm of Pituitary Gland|Malignant ACTH Secreting Neoplasm of the Pituitary|Malignant ACTH Secreting Neoplasm of the Pituitary Gland|Malignant ACTH Secreting Pituitary Gland Tumor|Malignant ACTH Secreting Pituitary Neoplasm|Malignant ACTH Secreting Pituitary Tumor|Malignant ACTH Secreting Tumor of Pituitary|Malignant ACTH Secreting Tumor of Pituitary Gland|Malignant ACTH Secreting Tumor of the Pituitary|Malignant ACTH Secreting Tumor of the Pituitary Gland|Malignant Adrenocorticotropin Producing Neoplasm of Pituitary|Malignant Adrenocorticotropin Producing Neoplasm of Pituitary Gland|Malignant Adrenocorticotropin Producing Neoplasm of the Pituitary|Malignant Adrenocorticotropin Producing Neoplasm of the Pituitary Gland|Malignant Adrenocorticotropin Producing Pituitary Gland Neoplasm|Malignant Adrenocorticotropin Producing Pituitary Gland Tumor|Malignant Adrenocorticotropin Producing Pituitary Neoplasm|Malignant Adrenocorticotropin Producing Pituitary Tumor|Malignant Adrenocorticotropin Producing Tumor of Pituitary|Malignant Adrenocorticotropin Producing Tumor of Pituitary Gland|Malignant Adrenocorticotropin Producing Tumor of the Pituitary|Malignant Adrenocorticotropin Producing Tumor of the Pituitary Gland|Malignant Adrenocorticotropin Secreting Pituitary Gland Neoplasm|Malignant Adrenocorticotropin Secreting Pituitary Gland Tumor|Malignant Adrenocorticotropin Secreting Pituitary Neoplasm|Malignant Adrenocorticotropin Secreting Pituitary Tumor|Malignant Corticotropin Secreting Pituitary Gland Neoplasm|Malignant Corticotropinoma of Pituitary|Malignant Corticotropinoma of Pituitary Gland|Malignant Corticotropinoma of the Pituitary|Malignant Corticotropinoma of the Pituitary Gland|Malignant Pituitary Corticotropinoma|Malignant Pituitary Gland Corticotropinoma	A rare, hormonally functioning or non-functioning pituitary gland adenocarcinoma that produces corticotropin.  It may be associated with Cushing disease. (NCI05)
C5965	Malignant_Thyroid_Stimulating_Hormone_Producing_Pituitary_Gland_Neoplasm	Pituitary_Gland_Carcinoma|Thyroid_Stimulating_Hormone_Producing_Pituitary_Gland_Neoplasm	TSH Producing Pituitary Gland Carcinoma|Malignant Pituitary Gland Thyrotropinoma|Malignant Pituitary Thyrotropinoma|Malignant TSH Producing Neoplasm of Pituitary|Malignant TSH Producing Neoplasm of Pituitary Gland|Malignant TSH Producing Neoplasm of the Pituitary|Malignant TSH Producing Neoplasm of the Pituitary Gland|Malignant TSH Producing Pituitary Gland Neoplasm|Malignant TSH Producing Pituitary Gland Tumor|Malignant TSH Producing Pituitary Neoplasm|Malignant TSH Producing Pituitary Tumor|Malignant TSH Producing Tumor of Pituitary|Malignant TSH Producing Tumor of Pituitary Gland|Malignant TSH Producing Tumor of the Pituitary|Malignant TSH Producing Tumor of the Pituitary Gland|Malignant TSH Secreting Neoplasm of Pituitary|Malignant TSH Secreting Neoplasm of Pituitary Gland|Malignant TSH Secreting Neoplasm of the Pituitary|Malignant TSH Secreting Neoplasm of the Pituitary Gland|Malignant TSH Secreting Pituitary Gland Neoplasm|Malignant TSH Secreting Pituitary Gland Tumor|Malignant TSH Secreting Pituitary Neoplasm|Malignant TSH Secreting Pituitary Tumor|Malignant TSH Secreting Tumor of Pituitary|Malignant TSH Secreting Tumor of Pituitary Gland|Malignant TSH Secreting Tumor of the Pituitary|Malignant TSH Secreting Tumor of the Pituitary Gland|Malignant Thyroid Stimulating Hormone Producing Neoplasm of Pituitary|Malignant Thyroid Stimulating Hormone Producing Neoplasm of Pituitary Gland|Malignant Thyroid Stimulating Hormone Producing Neoplasm of the Pituitary|Malignant Thyroid Stimulating Hormone Producing Neoplasm of the Pituitary Gland|Malignant Thyroid Stimulating Hormone Producing Pituitary Gland Neoplasm|Malignant Thyroid Stimulating Hormone Producing Pituitary Gland Tumor|Malignant Thyroid Stimulating Hormone Producing Pituitary Neoplasm|Malignant Thyroid Stimulating Hormone Producing Pituitary Tumor|Malignant Thyroid Stimulating Hormone Producing Tumor|Malignant Thyroid Stimulating Hormone Producing Tumor of Pituitary|Malignant Thyroid Stimulating Hormone Producing Tumor of Pituitary Gland|Malignant Thyroid Stimulating Hormone Producing Tumor of the Pituitary|Malignant Thyroid Stimulating Hormone Producing Tumor of the Pituitary Gland|Malignant Thyroid Stimulating Hormone Secreting Neoplasm of Pituitary|Malignant Thyroid Stimulating Hormone Secreting Neoplasm of Pituitary Gland|Malignant Thyroid Stimulating Hormone Secreting Neoplasm of the Pituitary|Malignant Thyroid Stimulating Hormone Secreting Neoplasm of the Pituitary Gland|Malignant Thyroid Stimulating Hormone Secreting Pituitary Gland Neoplasm|Malignant Thyroid Stimulating Hormone Secreting Pituitary Gland Tumor|Malignant Thyroid Stimulating Hormone Secreting Pituitary Neoplasm|Malignant Thyroid Stimulating Hormone Secreting Pituitary Tumor|Malignant Thyroid Stimulating Hormone Secreting Tumor of Pituitary|Malignant Thyroid Stimulating Hormone Secreting Tumor of Pituitary Gland|Malignant Thyroid Stimulating Hormone Secreting Tumor of the Pituitary|Malignant Thyroid Stimulating Hormone Secreting Tumor of the Pituitary Gland|Malignant Thyrotropinoma|Malignant Thyrotropinoma of Pituitary|Malignant Thyrotropinoma of Pituitary Gland|Malignant Thyrotropinoma of the Pituitary|Malignant Thyrotropinoma of the Pituitary Gland|Thyrotropin Producing Pituitary Gland Carcinoma	A rare, hormonally functioning or non-functioning pituitary gland adenocarcinoma that produces thyrotropin. (NCI05)
C5966	Anaplastic_Brain_Stem_Astrocytoma	Anaplastic_Astrocytoma|Anaplastic_Brain_Stem_Glioma|Brain_Stem_Astrocytoma	Anaplastic Brain Stem Astrocytoma|Anaplastic Brainstem Astrocytoma
C5967	Adult_Brain_Stem_Neoplasm	Adult_Brain_Neoplasm|Brain_Stem_Neoplasm	Adult Brain Stem Neoplasm|Adult Brain Stem Tumor|Adult Brainstem Neoplasm|Adult Brainstem Tumor|Neoplasm of Adult Brain Stem|Neoplasm of Adult Brainstem|Neoplasm of the Adult Brain Stem|Neoplasm of the Adult Brainstem|Tumor of Adult Brain Stem|Tumor of Adult Brainstem|Tumor of the Adult Brain Stem|Tumor of the Adult Brainstem
C5968	Adult_Cerebellar_Neoplasm	Adult_Brain_Neoplasm|Cerebellar_Neoplasm	Adult Cerebellar Neoplasm|Adult Cerebellar Neoplasms|Adult Cerebellar Tumor|Adult Cerebellar Tumors|Neoplasm of Adult Cerebellum|Neoplasm of the Adult Cerebellum|Tumor of Adult Cerebellum|Tumor of the Adult Cerebellum
C5969	Childhood_Brain_Stem_Neoplasm	Brain_Stem_Neoplasm|Childhood_Infratentorial_Neoplasm	Childhood Brain Stem Neoplasm|Childhood Brain Stem Tumor|Childhood Brainstem Neoplasm|Childhood Brainstem Tumor|Childhood Neoplasm of Brain Stem|Childhood Neoplasm of Brainstem|Childhood Neoplasm of the Brain Stem|Childhood Neoplasm of the Brainstem|Childhood Tumor of Brain Stem|Childhood Tumor of Brainstem|Childhood Tumor of the Brain Stem|Childhood Tumor of the Brainstem|Pediatric Brain Stem Neoplasm|Pediatric Brain Stem Tumor|Pediatric Brainstem Neoplasm|Pediatric Brainstem Tumor|Pediatric Neoplasm of Brain Stem|Pediatric Neoplasm of Brainstem|Pediatric Neoplasm of the Brain Stem|Pediatric Neoplasm of the Brainstem|Pediatric Tumor of Brain Stem|Pediatric Tumor of Brainstem|Pediatric Tumor of the Brain Stem|Pediatric Tumor of the Brainstem
C5970	Childhood_Cerebellar_Neoplasm	Cerebellar_Neoplasm|Childhood_Infratentorial_Neoplasm	Childhood Cerebellar Neoplasm|Childhood Cerebellar Neoplasms|Childhood Cerebellar Tumor|Childhood Cerebellar Tumors|Childhood Neoplasm of Cerebellum|Childhood Neoplasm of the Cerebellum|Childhood Tumor of Cerebellum|Childhood Tumor of the Cerebellum|Pediatric Cerebellar Neoplasm|Pediatric Cerebellar Tumor|Pediatric Neoplasm of Cerebellum|Pediatric Neoplasm of the Cerebellum|Pediatric Tumor of Cerebellum|Pediatric Tumor of the Cerebellum
C5971	Ear_Polyp	Benign_Ear_Neoplasm|Polyp	Ear Polyp|Aural Polyp|Polyp of Ear|Polyp of the Ear
C5972	Subglottic_Carcinoma	Laryngeal_Carcinoma|Malignant_Subglottis_Neoplasm	Subglottic Carcinoma|Cancer of Subglottis|Cancer of the Subglottis|Carcinoma of Subglottis|Carcinoma of the Subglottis|Subglottic Cancer|Subglottis Carcinoma
C5973	Supraglottic_Carcinoma	Laryngeal_Carcinoma|Malignant_Supraglottis_Neoplasm	Supraglottic Carcinoma|Cancer of Supraglottis|Cancer of the Supraglottis|Carcinoma of Supraglottis|Carcinoma of the Supraglottis|Supraglottic Cancer|Supraglottis Carcinoma
C5974	Parotid_Gland_Carcinoma_Ex_Pleomorphic_Adenoma	Major_Salivary_Gland_Carcinoma_Ex_Pleomorphic_Adenoma|Malignant_Parotid_Gland_Mixed_Tumor|Parotid_Gland_Carcinoma	Parotid Gland Carcinoma ex Pleomorphic Adenoma|Carcinoma ex Pleomorphic Adenoma of Parotid|Carcinoma ex Pleomorphic Adenoma of Parotid Gland|Carcinoma ex Pleomorphic Adenoma of the Parotid|Carcinoma ex Pleomorphic Adenoma of the Parotid Gland|Parotid Carcinoma ex Pleomorphic Adenoma
C5975	Major_Salivary_Gland_Carcinoma_Ex_Pleomorphic_Adenoma	Major_Salivary_Gland_Carcinoma|Malignant_Mixed_Tumor_of_the_Major_Salivary_Gland|Salivary_Gland_Carcinoma_Ex_Pleomorphic_Adenoma	Major Salivary Gland Carcinoma ex Pleomorphic Adenoma|Carcinoma ex Pleomorphic Adenoma of Major Salivary Gland|Carcinoma ex Pleomorphic Adenoma of the Major Salivary Gland
C5976	Minor_Salivary_Gland_Carcinoma_Ex_Pleomorphic_Adenoma	Malignant_Mixed_Tumor_of_the_Minor_Salivary_Gland|Minor_Salivary_Gland_Carcinoma|Salivary_Gland_Carcinoma_Ex_Pleomorphic_Adenoma	Minor Salivary Gland Carcinoma ex Pleomorphic Adenoma|Carcinoma ex Pleomorphic Adenoma of Minor Salivary Gland|Carcinoma ex Pleomorphic Adenoma of the Minor Salivary Gland
C5977	Submandibular_Gland_Carcinoma_Ex_Pleomorphic_Adenoma	Major_Salivary_Gland_Carcinoma_Ex_Pleomorphic_Adenoma|Malignant_Submandibular_Gland_Mixed_Tumor|Submandibular_Gland_Carcinoma	Submandibular Gland Carcinoma ex Pleomorphic Adenoma|Submaxillary Gland Carcinoma ex Pleomorphic Adenoma
C5978	Benign_Salivary_Gland_Myoepithelioma	Benign_Myoepithelioma|Benign_Salivary_Gland_Neoplasm|Salivary_Gland_Myoepithelial_Neoplasm	Benign Salivary Gland Myoepithelioma|Benign Myoepithelioma of the Salivary Gland	A rare benign tumor composed of sheets and islands of spindle, plasmacytoid, epithelioid, and clear cells that exhibit myoepithelial but not ductal differentiation. The average age of patients has been reported as 44 years. Clinically, these tumors present as asymptomatic masses. Discrimination between myoepithelioma and myoepithelial carcinoma is based primarily on the infiltrative growth of the latter. -- 2003
C5979	Salivary_Gland_Canalicular_Adenoma	Salivary_Gland_Monomorphic_Adenoma	Salivary Gland Canalicular Adenoma|Canalicular Adenoma of Salivary Gland|Canalicular Adenoma of the Salivary Gland	A benign epithelial neoplasm primarily composed of branching and interconnecting cords of single and double-cell thick rows of columnar epithelium in a very loose stroma. It often occurs in the upper lip, where only pleomorphic adenoma is more frequent. Asymptomatic swelling of the upper lip is the most common clinical finding. It may present clinically and histologically as a multifocal lesion, a feature not generally seen with other intraoral salivary gland tumors. -- 2003
C5980	Salivary_Gland_Cystadenocarcinoma	Cystadenocarcinoma|Salivary_Gland_Adenocarcinoma	Salivary Gland Cystadenocarcinoma|Cystadenocarcinoma of Salivary Gland|Cystadenocarcinoma of the Salivary Gland
C5981	Major_Salivary_Gland_Non-Hodgkin_s_Lymphoma	Lymphoma_by_Site|Malignant_Major_Salivary_Gland_Neoplasm|Non-Hodgkin_s_Lymphoma	Major Salivary Gland Non-Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma of Major Salivary Gland|Non-Hodgkin's Lymphoma of the Major Salivary Gland|Primary Major Salivary Gland Non-Hodgkin's Lymphoma
C5982	Parotid_Gland_Lipoma	Benign_Parotid_Gland_Neoplasm|Lipoma	Parotid Gland Lipoma|Lipoma of Parotid|Lipoma of Parotid Gland|Lipoma of the Parotid|Lipoma of the Parotid Gland|Parotid Lipoma
C5983	Major_Salivary_Gland_Sarcoma	Malignant_Major_Salivary_Gland_Neoplasm|Soft_Tissue_Sarcoma	Major Salivary Gland Sarcoma|Sarcoma of Major Salivary Gland|Sarcoma of the Major Salivary Gland
C5985	Stage_IVA_Oropharyngeal_Carcinoma	Stage_IVA_Pharyngeal_Cancer|Stage_IV_Oropharyngeal_Carcinoma	Stage IVA Oropharyngeal Carcinoma|Stage IVA Carcinoma of Oropharynx|Stage IVA Carcinoma of the Oropharynx|Stage IVA Oropharynx Carcinoma
C5986	Stage_IVB_Oropharyngeal_Carcinoma	Stage_IVB_Pharyngeal_Cancer|Stage_IV_Oropharyngeal_Carcinoma	Stage IVB Oropharyngeal Carcinoma|Stage IVB Carcinoma of Oropharynx|Stage IVB Carcinoma of the Oropharynx|Stage IVB Oropharynx Carcinoma
C5987	Stage_IVC_Oropharyngeal_Carcinoma	Stage_IVC_Pharyngeal_Cancer|Stage_IV_Oropharyngeal_Carcinoma	Stage IVC Oropharyngeal Carcinoma|Stage IVC Carcinoma of Oropharynx|Stage IVC Carcinoma of the Oropharynx|Stage IVC Oropharynx Carcinoma
C5988	Oropharyngeal_Polyp	Benign_Oropharyngeal_Neoplasm|Polyp	Oropharyngeal Polyp|Oropharynx Polyp|Polyp of Oropharynx|Polyp of the Oropharynx
C5989	Tonsillar_Lipoma	Benign_Tonsillar_Neoplasm|Lipoma	Tonsillar Lipoma|Lipoma of Tonsil|Lipoma of the Tonsil|Tonsil Lipoma
C5990	Posterior_Tongue_Mucoepidermoid_Carcinoma	Mucoepidermoid_Carcinoma|Posterior_Tongue_Carcinoma	Posterior Tongue Mucoepidermoid Carcinoma|Base of Tongue Mucoepidermoid Carcinoma|Base of the Tongue Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Base of Tongue|Mucoepidermoid Carcinoma of Posterior Tongue|Mucoepidermoid Carcinoma of the Base of the Tongue|Mucoepidermoid Carcinoma of the Posterior Tongue
C5991	Posterior_Tongue_Adenoid_Cystic_Carcinoma	Oropharyngeal_Adenoid_Cystic_Carcinoma|Posterior_Tongue_Carcinoma	Posterior Tongue Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Base of Tongue|Adenoid Cystic Carcinoma of Posterior Tongue|Adenoid Cystic Carcinoma of the Base of the Tongue|Adenoid Cystic Carcinoma of the Posterior Tongue|Base of Tongue Adenoid Cystic Carcinoma|Base of the Tongue Adenoid Cystic Carcinoma
C5992	Stage_IVA_Hypopharyngeal_Carcinoma	Stage_IVA_Pharyngeal_Cancer|Stage_IV_Hypopharyngeal_Carcinoma	Stage IVA Hypopharyngeal Carcinoma|Stage IVA Carcinoma of Hypopharynx|Stage IVA Carcinoma of the Hypopharynx|Stage IVA Hypopharynx Carcinoma
C5993	Stage_IVB_Hypopharyngeal_Carcinoma	Stage_IVB_Pharyngeal_Cancer|Stage_IV_Hypopharyngeal_Carcinoma	Stage IVB Hypopharyngeal Carcinoma|Stage IVB Carcinoma of Hypopharynx|Stage IVB Carcinoma of the Hypopharynx|Stage IVB Hypopharynx Carcinoma
C5994	Stage_IVC_Hypopharyngeal_Carcinoma	Stage_IVC_Pharyngeal_Cancer|Stage_IV_Hypopharyngeal_Carcinoma	Stage IVC Hypopharyngeal Carcinoma|Stage IVC Carcinoma of Hypopharynx|Stage IVC Carcinoma of the Hypopharynx|Stage IVC Hypopharynx Carcinoma
C5995	Stage_IVC_Nasopharyngeal_Carcinoma	Stage_IVC_Pharyngeal_Cancer|Stage_IV_Nasopharyngeal_Carcinoma	Stage IVC Nasopharyngeal Carcinoma|Stage IVC Carcinoma of Nasopharynx|Stage IVC Carcinoma of the Nasopharynx|Stage IVC Nasopharynx Carcinoma
C5996	Stage_IVB_Nasopharyngeal_Carcinoma	Stage_IVB_Pharyngeal_Cancer|Stage_IV_Nasopharyngeal_Carcinoma	Stage IVB Nasopharyngeal Carcinoma|Stage IVB Carcinoma of Nasopharynx|Stage IVB Carcinoma of the Nasopharynx|Stage IVB Nasopharynx Carcinoma
C5997	Stage_IVA_Nasopharyngeal_Carcinoma	Stage_IVA_Pharyngeal_Cancer|Stage_IV_Nasopharyngeal_Carcinoma	Stage IVA Nasopharyngeal Carcinoma|Stage IVA Carcinoma of Nasopharynx|Stage IVA Carcinoma of the Nasopharynx|Stage IVA Nasopharynx Carcinoma
C5998	Stage_IIA_Nasopharyngeal_Carcinoma	Stage_II_Nasopharyngeal_Carcinoma	Stage IIA Nasopharyngeal Carcinoma|Stage IIA Carcinoma of Nasopharynx|Stage IIA Carcinoma of the Nasopharynx|Stage IIA Nasopharynx Carcinoma
C5999	Stage_IIB_Nasopharyngeal_Carcinoma	Stage_II_Nasopharyngeal_Carcinoma	Stage IIB Nasopharyngeal Carcinoma|Stage IIB Carcinoma of Nasopharynx|Stage IIB Carcinoma of the Nasopharynx|Stage IIB Nasopharynx Carcinoma
C6000	Stage_IVA_Pharyngeal_Cancer	Stage_IV_Pharyngeal_Cancer	Stage IVA Pharyngeal Cancer|Pharyngeal Cancer Stage IVA|Stage IVA Carcinoma of Pharynx|Stage IVA Carcinoma of the Pharynx|Stage IVA Pharyngeal Carcinoma|Stage IVA Pharynx Carcinoma
C6001	Stage_IVB_Pharyngeal_Cancer	Stage_IV_Pharyngeal_Cancer	Stage IVB Pharyngeal Cancer|Pharyngeal Cancer Stage IVB|Stage IVB Carcinoma of Pharynx|Stage IVB Carcinoma of the Pharynx|Stage IVB Pharyngeal Carcinoma|Stage IVB Pharynx Carcinoma
C6002	Stage_IVC_Pharyngeal_Cancer	Stage_IV_Pharyngeal_Cancer	Stage IVC Pharyngeal Cancer|Pharyngeal Cancer Stage IVC|Stage IVC Carcinoma of Pharynx|Stage IVC Carcinoma of the Pharynx|Stage IVC Pharyngeal Carcinoma|Stage IVC Pharynx Carcinoma
C6003	Stage_IVC_Laryngeal_Cancer	Stage_IV_Laryngeal_Cancer	Stage IVC Laryngeal Cancer|Laryngeal Cancer Stage IVC|Stage IVC Carcinoma of Larynx|Stage IVC Carcinoma of the Larynx|Stage IVC Laryngeal Carcinoma|Stage IVC Larynx Carcinoma
C6004	Stage_IVB_Laryngeal_Cancer	Stage_IV_Laryngeal_Cancer	Stage IVB Laryngeal Cancer|Laryngeal Cancer Stage IVB|Stage IVB Carcinoma of Larynx|Stage IVB Carcinoma of the Larynx|Stage IVB Laryngeal Carcinoma|Stage IVB Larynx Carcinoma
C6005	Stage_IVA_Laryngeal_Cancer	Stage_IV_Laryngeal_Cancer	Stage IVA Laryngeal Cancer|Laryngeal Cancer Stage IVA|Stage IVA Carcinoma of Larynx|Stage IVA Carcinoma of the Larynx|Stage IVA Laryngeal Carcinoma|Stage IVA Larynx Carcinoma
C6006	Stage_I_Paranasal_Sinus_Cancer	Paranasal_Sinus_Carcinoma	Stage I Paranasal Sinus Cancer|Paranasal Sinus Cancer Stage I|Stage I Accessory Sinus Carcinoma|Stage I Carcinoma of Accessory Sinus|Stage I Carcinoma of Paranasal Sinus|Stage I Carcinoma of the Accessory Sinus|Stage I Carcinoma of the Paranasal Sinus|Stage I Paranasal Sinus Carcinoma
C6007	Stage_II_Paranasal_Sinus_Cancer	Paranasal_Sinus_Carcinoma	Stage II Paranasal Sinus Cancer|Paranasal Sinus Cancer Stage II|Stage II Accessory Sinus Carcinoma|Stage II Carcinoma of Accessory Sinus|Stage II Carcinoma of Paranasal Sinus|Stage II Carcinoma of the Accessory Sinus|Stage II Carcinoma of the Paranasal Sinus|Stage II Paranasal Sinus Carcinoma
C6008	Stage_III_Paranasal_Sinus_Cancer	Paranasal_Sinus_Carcinoma	Stage III Paranasal Sinus Cancer|Paranasal Sinus Cancer Stage III|Stage III Accessory Sinus Carcinoma|Stage III Carcinoma of Accessory Sinus|Stage III Carcinoma of Paranasal Sinus|Stage III Carcinoma of the Accessory Sinus|Stage III Carcinoma of the Paranasal Sinus|Stage III Paranasal Sinus Carcinoma
C6009	Stage_IV_Paranasal_Sinus_Cancer	Paranasal_Sinus_Carcinoma	Stage IV Paranasal Sinus Cancer|Paranasal Sinus Cancer Stage IV|Stage IV Accessory Sinus Carcinoma|Stage IV Carcinoma of Accessory Sinus|Stage IV Carcinoma of Paranasal Sinus|Stage IV Carcinoma of the Accessory Sinus|Stage IV Carcinoma of the Paranasal Sinus|Stage IV Paranasal Sinus Carcinoma
C6010	Stage_IV_Nasal_Cavity_Carcinoma	Nasal_Cavity_Carcinoma	Stage IV Nasal Cavity Carcinoma|Stage IV Carcinoma of Nasal Cavity|Stage IV Carcinoma of the Nasal Cavity
C6011	Stage_III_Nasal_Cavity_Carcinoma	Nasal_Cavity_Carcinoma	Stage III Nasal Cavity Carcinoma|Stage III Carcinoma of Nasal Cavity|Stage III Carcinoma of the Nasal Cavity
C6012	Stage_II_Nasal_Cavity_Carcinoma	Nasal_Cavity_Carcinoma	Stage II Nasal Cavity Carcinoma|Stage II Carcinoma of Nasal Cavity|Stage II Carcinoma of the Nasal Cavity
C6013	Stage_I_Nasal_Cavity_Carcinoma	Nasal_Cavity_Carcinoma	Stage I Nasal Cavity Carcinoma|Stage I Carcinoma of Nasal Cavity|Stage I Carcinoma of the Nasal Cavity
C6014	Paranasal_Sinus_Carcinoma	Carcinoma|Malignant_Paranasal_Sinus_Neoplasm	Paranasal Sinus Carcinoma|Accessory Sinus Cancer|Accessory Sinus Carcinoma|Carcinoma of Accessory Sinus|Carcinoma of Paranasal Sinus|Carcinoma of the Accessory Sinus|Carcinoma of the Paranasal Sinus|Paranasal Sinus Cancer	Malignant neoplasm of the nasal cavity
C6015	Nasal_Cavity_Adenocarcinoma	Adenocarcinoma|Nasal_Cavity_Carcinoma	Nasal Cavity Adenocarcinoma|Adenocarcinoma of Nasal Cavity|Adenocarcinoma of the Nasal Cavity
C6016	Paranasal_Sinus_Olfactory_Neuroblastoma	Malignant_Paranasal_Sinus_Neoplasm|Olfactory_Neuroblastoma	Paranasal Sinus Olfactory Neuroblastoma|Accessory Sinus Esthesioneuroblastoma|Esthesioneuroblastoma of Accessory Sinus|Esthesioneuroblastoma of Paranasal Sinus|Esthesioneuroblastoma of the Accessory Sinus|Esthesioneuroblastoma of the Paranasal Sinus|Paranasal Sinus Esthesioneuroblastoma
C6017	Paranasal_Sinus_Adenocarcinoma	Adenocarcinoma|Paranasal_Sinus_Carcinoma	Paranasal Sinus Adenocarcinoma|Accessory Sinus Adenocarcinoma|Adenocarcinoma of Accessory Sinus|Adenocarcinoma of Paranasal Sinus|Adenocarcinoma of the Accessory Sinus|Adenocarcinoma of the Paranasal Sinus
C6018	Paranasal_Sinus_Mucoepidermoid_Carcinoma	Mucoepidermoid_Carcinoma|Paranasal_Sinus_Carcinoma	Paranasal Sinus Mucoepidermoid Carcinoma|Accessory Sinus Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Accessory Sinus|Mucoepidermoid Carcinoma of Paranasal Sinus|Mucoepidermoid Carcinoma of the Accessory Sinus|Mucoepidermoid Carcinoma of the Paranasal Sinus
C6019	Paranasal_Sinus_Adenoid_Cystic_Carcinoma	Adenoid_Cystic_Carcinoma|Paranasal_Sinus_Carcinoma	Paranasal Sinus Adenoid Cystic Carcinoma|Accessory Sinus Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Accessory Sinus|Adenoid Cystic Carcinoma of Paranasal Sinus|Adenoid Cystic Carcinoma of the Accessory Sinus|Adenoid Cystic Carcinoma of the Paranasal Sinus
C6020	Laryngeal_Sarcoma	Malignant_Laryngeal_Neoplasm|Soft_Tissue_Sarcoma	Laryngeal Sarcoma|Larynx Sarcoma|Sarcoma of Larynx|Sarcoma of the Larynx
C6021	Laryngeal_Liposarcoma	Laryngeal_Sarcoma|Liposarcoma	Laryngeal Liposarcoma|Larynx Liposarcoma|Liposarcoma of Larynx|Liposarcoma of the Larynx
C6022	Laryngeal_Leiomyosarcoma	Laryngeal_Sarcoma|Leiomyosarcoma	Laryngeal Leiomyosarcoma|Larynx Leiomyosarcoma|Leiomyosarcoma of Larynx|Leiomyosarcoma of the Larynx
C6023	Laryngeal_Neuroendocrine_Neoplasm	Laryngeal_Neoplasm|Neuroendocrine_Neoplasm	Laryngeal Neuroendocrine Neoplasm|Laryngeal Neuroendocrine Tumor|Larynx Neuroendocrine Neoplasm|Larynx Neuroendocrine Tumor|Neuroendocrine Neoplasm of Larynx|Neuroendocrine Neoplasm of the Larynx|Neuroendocrine Tumor of Larynx|Neuroendocrine Tumor of the Larynx
C6024	Laryngeal_Carcinoid_Tumor	Foregut_Carcinoid_Tumor|Laryngeal_Neuroendocrine_Neoplasm	Laryngeal Carcinoid Tumor|Carcinoid Neoplasm of Larynx|Carcinoid Neoplasm of the Larynx|Carcinoid Tumor of Larynx|Carcinoid Tumor of the Larynx|Laryngeal Carcinoid Neoplasm|Larynx Carcinoid Neoplasm|Larynx Carcinoid Tumor
C6025	Laryngeal_Small_Cell_Carcinoma	Laryngeal_Carcinoma|Laryngeal_Neuroendocrine_Neoplasm|Small_Cell_Carcinoma	Laryngeal Small Cell Carcinoma|Larynx Small Cell Carcinoma|Small Cell Carcinoma of Larynx|Small Cell Carcinoma of the Larynx
C6026	Subglottic_Hemangioma	Benign_Subglottis_Neoplasm|Hemangioma	Subglottic Hemangioma|Angioma of Subglottis|Angioma of the Subglottis|Hemangioma of Subglottis|Hemangioma of the Subglottis|Subglottic Angioma|Subglottis Angioma|Subglottis Hemangioma
C6027	Laryngeal_Leiomyoma	Benign_Laryngeal_Neoplasm|Leiomyoma	Laryngeal Leiomyoma|Larynx Leiomyoma|Leiomyoma of Larynx|Leiomyoma of the Larynx
C6028	Metastatic_Neoplasm_to_the_Hypopharynx	Malignant_Hypopharyngeal_Neoplasm|Metastatic_Neoplasm_to_the_Pharynx	Metastatic Malignant Neoplasm to the Hypopharynx|Metastatic Neoplasm to the Hypopharynx|Metastatic Tumor to the Hypopharynx
C6029	Metastatic_Neoplasm_to_the_Oropharynx	Malignant_Oropharyngeal_Neoplasm|Metastatic_Neoplasm_to_the_Pharynx	Metastatic Malignant Neoplasm to the Oropharynx|Metastasis to the Oropharynx|Metastatic Neoplasm to the Oropharynx|Metastatic Tumor to the Oropharynx
C6030	Metastatic_Neoplasm_to_the_Nasopharynx	Malignant_Nasopharyngeal_Neoplasm|Metastatic_Neoplasm_to_the_Pharynx	Metastatic Malignant Neoplasm to the Nasopharynx|Metastasis to the Nasopharynx|Metastatic Neoplasm to the Nasopharynx|Metastatic Tumor to the Nasopharynx
C6031	Metastatic_Neoplasm_to_the_Larynx	Malignant_Laryngeal_Neoplasm|Metastatic_Neoplasm_to_the_Neck	Metastatic Malignant Neoplasm to the Larynx|Metastatic Neoplasm to the Larynx|Metastatic Tumor to the Larynx
C6032	Parathyroid_Chief_Cell_Hyperplasia	Parathyroid_Hyperplasia	Parathyroid Chief Cell Hyperplasia|Chief Cell Hyperplasia of Parathyroid|Chief Cell Hyperplasia of the Parathyroid
C6033	Parathyroid_Clear_Cell_Hyperplasia	Parathyroid_Hyperplasia	Parathyroid Clear Cell Hyperplasia|Clear Cell Hyperplasia of Parathyroid|Clear Cell Hyperplasia of the Parathyroid
C6034	Nasopharyngeal_Polyp	Benign_Nasopharyngeal_Neoplasm|Polyp	Nasopharyngeal Polyp|Nasopharynx Polyp|Polyp of Nasopharynx|Polyp of the Nasopharynx
C6035	Stage_0_Nasopharyngeal_Undifferentiated_Carcinoma	Nasopharyngeal_Undifferentiated_Carcinoma	Stage 0 Nasopharyngeal Undifferentiated Carcinoma|Nasopharyngeal Undifferentiated Carcinoma Stage O|Stage 0 Lymphoepithelioma of Nasopharynx|Stage 0 Lymphoepithelioma of the Nasopharynx|Stage 0 Nasopharyngeal Lymphoepithelioma|Stage 0 Nasopharynx Lymphoepithelioma
C6036	Stage_0_Nasopharyngeal_Squamous_Cell_Carcinoma	Nasopharyngeal_Squamous_Cell_Carcinoma|Stage_0_Nasopharyngeal_Carcinoma	Stage 0 Nasopharyngeal Squamous Cell Carcinoma|Epidermoid Carcinoma in situ of Nasopharynx|Epidermoid Carcinoma in situ of the Nasopharynx|Nasopharyngeal Epidermoid Carcinoma in situ|Nasopharyngeal Squamous Cell Carcinoma in situ|Nasopharynx Epidermoid Carcinoma in situ|Nasopharynx Squamous Cell Carcinoma in situ|Squamous Cell Carcinoma in situ of Nasopharynx|Squamous Cell Carcinoma in situ of the Nasopharynx|Stage 0 Epidermoid Carcinoma of Nasopharynx|Stage 0 Epidermoid Carcinoma of the Nasopharynx|Stage 0 Nasopharyngeal Epidermoid Carcinoma|Stage 0 Nasopharyngeal Keratinizing Squamous Cell Carcinoma|Stage 0 Nasopharynx Epidermoid Carcinoma|Stage 0 Nasopharynx Squamous Cell Carcinoma|Stage 0 Squamous Cell Carcinoma of Nasopharynx|Stage 0 Squamous Cell Carcinoma of the Nasopharynx
C6037	Squamous_Papilloma_of_the_Nasopharynx	Benign_Nasopharyngeal_Neoplasm|Squamous_Cell_Papilloma	Squamous Papilloma of the Nasopharynx|Nasopharyngeal Papilloma|Nasopharyngeal Squamous Papilloma|Nasopharynx Papilloma|Papilloma of Nasopharynx|Papilloma of the Nasopharynx|Squamous Papilloma of Nasopharynx
C6038	Oropharyngeal_Squamous_Papilloma	Benign_Oropharyngeal_Neoplasm|Squamous_Cell_Papilloma	Oropharyngeal Squamous Papilloma|Oropharyngeal Papilloma|Oropharynx Papilloma|Papilloma of Oropharynx|Papilloma of the Oropharynx|Squamous Papilloma of Oropharynx|Squamous Papilloma of the Oropharynx
C6039	Stage_0_Oropharyngeal_Squamous_Cell_Carcinoma	Oropharyngeal_Squamous_Cell_Carcinoma|Stage_0_Oropharyngeal_Carcinoma	Stage 0 Oropharyngeal Squamous Cell Carcinoma|Epidermoid Carcinoma in situ of Oropharynx|Epidermoid Carcinoma in situ of the Oropharynx|Oropharyngeal Epidermoid Carcinoma in situ|Oropharyngeal Squamous Cell Carcinoma in situ|Oropharynx Epidermoid Carcinoma in situ|Oropharynx Squamous Cell Carcinoma in situ|Squamous Cell Carcinoma in situ of Oropharynx|Squamous Cell Carcinoma in situ of the Oropharynx|Stage 0 Epidermoid Carcinoma of Oropharynx|Stage 0 Epidermoid Carcinoma of the Oropharynx|Stage 0 Oropharyngeal Epidermoid Carcinoma|Stage 0 Oropharynx Epidermoid Carcinoma|Stage 0 Oropharynx Squamous Cell Carcinoma|Stage 0 Squamous Cell Carcinoma of Oropharynx|Stage 0 Squamous Cell Carcinoma of the Oropharynx
C6040	Poorly_Differentiated_Thyroid_Carcinoma	Thyroid_Adenocarcinoma	Poorly Differentiated Thyroid Gland Carcinoma|Insular Carcinoma|Poorly Differentiated Carcinoma of Thyroid Gland|Poorly Differentiated Carcinoma of the Thyroid Gland|Poorly Differentiated Thyroid Carcinoma|Thyroid Gland Poorly Differentiated Carcinoma	An adenocarcinoma arising from the thyroid gland showing only limited evidence of follicular cell differentiation.  Microscopically, the adenocarcinoma cells are arranged in insular, solid, and trabecular patterns.  There is associated necrosis, and vascular invasion.  The prognosis depends on the tumor stage, complete or partial surgical removal of the tumor, and the degree of response to radioactive iodine therapy (adapted from WHO Tumors of Endocrine Organs, IARC Press, Lyon 2004)
C6041	Thyroid_Sarcoma	Malignant_Thyroid_Neoplasm|Soft_Tissue_Sarcoma	Thyroid Gland Sarcoma|Sarcoma of Thyroid|Sarcoma of Thyroid Gland|Sarcoma of the Thyroid|Sarcoma of the Thyroid Gland|Thyroid Sarcoma	A malignant mesenchymal tumor primarily involving the thyroid gland. (NCI05)
C6042	Thyroid_Hurthle_Cell_Adenoma	Oxyphilic_Adenoma|Thyroid_Adenoma|Thyroid_Gland_Oncocytic_Neoplasm	Thyroid Gland Oncocytic Adenoma|Benign Oncocytoma of Thyroid|Benign Oncocytoma of Thyroid Gland|Benign Oncocytoma of the Thyroid|Benign Oncocytoma of the Thyroid Gland|Benign Thyroid Gland Oncocytoma|Benign Thyroid Oncocytoma|Follicular Adenoma of Thyroid Gland of Oxyphilic Cell Type|Follicular Adenoma of Thyroid of Oxyphilic Cell Type|Follicular Adenoma of the Thyroid Gland of the Oxyphilic Cell Type|Follicular Adenoma of the Thyroid of the Oxyphilic Cell Type|Hurthle Cell Adenoma|Hurthle Cell Adenoma of Thyroid|Hurthle Cell Adenoma of Thyroid Gland|Hurthle Cell Adenoma of the Thyroid|Hurthle Cell Adenoma of the Thyroid Gland|Oncocytic Adenoma of Thyroid|Oncocytic Adenoma of Thyroid Gland|Oncocytic Adenoma of the Thyroid|Oncocytic Adenoma of the Thyroid Gland|Thyroid Follicular Adenoma of Oxyphilic Cell Type|Thyroid Follicular Adenoma of the Oxyphilic Cell Type|Thyroid Gland Follicular Adenoma of Oxyphilic Cell Type|Thyroid Gland Follicular Adenoma of the Oxyphilic Cell Type|Thyroid Gland Hurthle Cell Adenoma|Thyroid Hurthle Cell Adenoma|Thyroid Oncocytic Adenoma	A thyroid gland adenoma composed of large cells with abundant granular eosinophilic cytoplasm and large nuclei with prominent nucleoli. (NCI05)
C6043	Thyroid_Angiosarcoma	Angiosarcoma|Thyroid_Sarcoma	Thyroid Gland Angiosarcoma|Angiosarcoma of Thyroid|Angiosarcoma of Thyroid Gland|Angiosarcoma of the Thyroid|Angiosarcoma of the Thyroid Gland|Hemangiosarcoma of Thyroid|Hemangiosarcoma of Thyroid Gland|Hemangiosarcoma of the Thyroid|Hemangiosarcoma of the Thyroid Gland|Thyroid Angiosarcoma|Thyroid Gland Hemangiosarcoma|Thyroid Gland Malignant Hemangioendothelioma|Thyroid Hemangiosarcoma	A usually aggressive malignant vascular tumor primarily involving the thyroid gland.  It is often associated with longstanding nodular goiter. (NCI05)
C6044	Thyroid_Non-Hodgkin_s_Lymphoma	Non-Hodgkin_s_Lymphoma|Thyroid_Lymphoma	Thyroid Gland Non-Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma of Thyroid|Non-Hodgkin's Lymphoma of Thyroid Gland|Non-Hodgkin's Lymphoma of the Thyroid|Non-Hodgkin's Lymphoma of the Thyroid Gland|Primary Thyroid Gland Non-Hodgkin's Lymphoma|Thyroid Non-Hodgkin Lymphoma|Thyroid Non-Hodgkin's Lymphoma	A non-Hodgkin's lymphoma primarily involving the thyroid gland.  The vast majority of cases are either mucosa-associated lymphoid tissue lymphomas or diffuse large B-cell lymphomas. (NCI05)
C6046	Thyroid_Diffuse_Large_B-Cell_Lymphoma	Diffuse_Large_B-Cell_Lymphoma|Thyroid_Non-Hodgkin_s_Lymphoma	Thyroid Gland Diffuse Large B-Cell Lymphoma|Diffuse Large B-Cell Lymphoma of Thyroid|Diffuse Large B-Cell Lymphoma of Thyroid Gland|Diffuse Large B-Cell Lymphoma of the Thyroid|Diffuse Large B-Cell Lymphoma of the Thyroid Gland|Primary Thyroid Gland Diffuse Large B-Cell Lymphoma|Thyroid Diffuse Large B-Cell Lymphoma	A diffuse large B-cell lymphoma primarily involving the thyroid gland. (NCI05)
C6048	Stage_0_Hypopharyngeal_Squamous_Cell_Carcinoma	Hypopharyngeal_Squamous_Cell_Carcinoma|Stage_0_Hypopharyngeal_Cancer	Stage 0 Hypopharyngeal Squamous Cell Carcinoma|Epidermoid Carcinoma in situ of Hypopharynx|Epidermoid Carcinoma in situ of the Hypopharynx|Hypopharyngeal Epidermoid Carcinoma in situ|Hypopharyngeal Squamous Cell Carcinoma in situ|Hypopharynx Epidermoid Carcinoma in situ|Hypopharynx Squamous Cell Carcinoma in situ|Squamous Cell Carcinoma in situ of Hypopharynx|Squamous Cell Carcinoma in situ of the Hypopharynx|Stage 0 Epidermoid Carcinoma of Hypopharynx|Stage 0 Epidermoid Carcinoma of the Hypopharynx|Stage 0 Hypopharyngeal Epidermoid Carcinoma|Stage 0 Hypopharynx Epidermoid Carcinoma|Stage 0 Hypopharynx Squamous Cell Carcinoma|Stage 0 Squamous Cell Carcinoma of Hypopharynx|Stage 0 Squamous Cell Carcinoma of the Hypopharynx
C6049	Tracheal_Leiomyoma	Benign_Tracheal_Neoplasm|Leiomyoma	Tracheal Leiomyoma|Leiomyoma of Trachea|Leiomyoma of the Trachea|Trachea Leiomyoma
C6050	Tracheal_Sarcoma	Malignant_Tracheal_Neoplasm|Soft_Tissue_Sarcoma	Tracheal Sarcoma|Sarcoma of Trachea|Sarcoma of the Trachea|Trachea Sarcoma
C6051	Tracheal_Adenoid_Cystic_Carcinoma	Adenoid_Cystic_Carcinoma|Tracheal_Carcinoma	Tracheal Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Trachea|Adenoid Cystic Carcinoma of the Trachea|Trachea Adenoid Cystic Carcinoma
C6052	Stage_0_Oral_Cavity_Squamous_Cell_Carcinoma	Oral_Cavity_Squamous_Cell_Carcinoma|Stage_0_Oral_Cavity_Carcinoma|Stage_0_Squamous_Cell_Carcinoma	Stage 0 Oral Cavity Squamous Cell Carcinoma|Epidermoid Carcinoma in situ of Mouth|Epidermoid Carcinoma in situ of Oral Cavity|Epidermoid Carcinoma in situ of the Mouth|Epidermoid Carcinoma in situ of the Oral Cavity|Mouth Epidermoid Carcinoma in situ|Mouth Squamous Cell Carcinoma in situ|Oral Cavity Epidermoid Carcinoma in situ|Oral Cavity Squamous Cell Carcinoma in situ|Squamous Cell Carcinoma in situ of Mouth|Squamous Cell Carcinoma in situ of Oral Cavity|Squamous Cell Carcinoma in situ of the Mouth|Squamous Cell Carcinoma in situ of the Oral Cavity|Stage 0 Epidermoid Carcinoma of Mouth|Stage 0 Epidermoid Carcinoma of Oral Cavity|Stage 0 Epidermoid Carcinoma of the Mouth|Stage 0 Epidermoid Carcinoma of the Oral Cavity|Stage 0 Mouth Epidermoid Carcinoma|Stage 0 Oral Cavity Epidermoid Carcinoma|Stage 0 Squamous Cell Carcinoma of Mouth|Stage 0 Squamous Cell Carcinoma of Oral Cavity|Stage 0 Squamous Cell Carcinoma of the Mouth|Stage 0 Squamous Cell Carcinoma of the Oral Cavity
C6053	Stage_I_Oral_Cavity_Squamous_Cell_Carcinoma	Oral_Cavity_Squamous_Cell_Carcinoma|Stage_I_Oral_Cavity_Carcinoma	Stage I Oral Cavity Squamous Cell Carcinoma|Stage I Epidermoid Carcinoma of Mouth|Stage I Epidermoid Carcinoma of Oral Cavity|Stage I Epidermoid Carcinoma of the Mouth|Stage I Epidermoid Carcinoma of the Oral Cavity|Stage I Mouth Epidermoid Carcinoma|Stage I Mouth Squamous Cell Carcinoma|Stage I Oral Cavity Epidermoid Carcinoma|Stage I Squamous Cell Carcinoma of Mouth|Stage I Squamous Cell Carcinoma of Oral Cavity|Stage I Squamous Cell Carcinoma of the Mouth|Stage I Squamous Cell Carcinoma of the Oral Cavity
C6054	Stage_II_Oral_Cavity_Squamous_Cell_Carcinoma	Oral_Cavity_Squamous_Cell_Carcinoma|Stage_II_Oral_Cavity_Carcinoma	Stage II Oral Cavity Squamous Cell Carcinoma|Stage II Epidermoid Carcinoma of Mouth|Stage II Epidermoid Carcinoma of Oral Cavity|Stage II Epidermoid Carcinoma of the Mouth|Stage II Epidermoid Carcinoma of the Oral Cavity|Stage II Mouth Epidermoid Carcinoma|Stage II Mouth Squamous Cell Carcinoma|Stage II Oral Cavity Epidermoid Carcinoma|Stage II Squamous Cell Carcinoma of Mouth|Stage II Squamous Cell Carcinoma of Oral Cavity|Stage II Squamous Cell Carcinoma of the Mouth|Stage II Squamous Cell Carcinoma of the Oral Cavity
C6055	Stage_III_Oral_Cavity_Squamous_Cell_Carcinoma	Oral_Cavity_Squamous_Cell_Carcinoma|Stage_III_Oral_Cavity_Carcinoma	Stage III Oral Cavity Squamous Cell Carcinoma|Stage III Epidermoid Carcinoma of Mouth|Stage III Epidermoid Carcinoma of Oral Cavity|Stage III Epidermoid Carcinoma of the Mouth|Stage III Epidermoid Carcinoma of the Oral Cavity|Stage III Mouth Epidermoid Carcinoma|Stage III Mouth Squamous Cell Carcinoma|Stage III Oral Cavity Epidermoid Carcinoma|Stage III Squamous Cell Carcinoma of Mouth|Stage III Squamous Cell Carcinoma of Oral Cavity|Stage III Squamous Cell Carcinoma of the Mouth|Stage III Squamous Cell Carcinoma of the Oral Cavity
C6056	Stage_IV_Oral_Cavity_Squamous_Cell_Carcinoma	Oral_Cavity_Squamous_Cell_Carcinoma|Stage_IV_Oral_Cavity_Carcinoma	Stage IV Oral Cavity Squamous Cell Carcinoma|Stage IV Epidermoid Carcinoma of Mouth|Stage IV Epidermoid Carcinoma of Oral Cavity|Stage IV Epidermoid Carcinoma of the Mouth|Stage IV Epidermoid Carcinoma of the Oral Cavity|Stage IV Mouth Epidermoid Carcinoma|Stage IV Mouth Squamous Cell Carcinoma|Stage IV Oral Cavity Epidermoid Carcinoma|Stage IV Squamous Cell Carcinoma of Mouth|Stage IV Squamous Cell Carcinoma of Oral Cavity|Stage IV Squamous Cell Carcinoma of the Mouth|Stage IV Squamous Cell Carcinoma of the Oral Cavity
C6057	Stage_IVA_Oral_Cavity_Squamous_Cell_Carcinoma	Stage_IVA_Oral_Cavity_Carcinoma|Stage_IV_Oral_Cavity_Squamous_Cell_Carcinoma	Stage IVA Oral Cavity Squamous Cell Carcinoma|Stage IVA Epidermoid Carcinoma of Mouth|Stage IVA Epidermoid Carcinoma of Oral Cavity|Stage IVA Epidermoid Carcinoma of the Mouth|Stage IVA Epidermoid Carcinoma of the Oral Cavity|Stage IVA Mouth Epidermoid Carcinoma|Stage IVA Mouth Squamous Cell Carcinoma|Stage IVA Oral Cavity Epidermoid Carcinoma|Stage IVA Squamous Cell Carcinoma of Mouth|Stage IVA Squamous Cell Carcinoma of Oral Cavity|Stage IVA Squamous Cell Carcinoma of the Mouth|Stage IVA Squamous Cell Carcinoma of the Oral Cavity
C6058	Stage_IVB_Oral_Cavity_Squamous_Cell_Carcinoma	Stage_IVB_Oral_Cavity_Carcinoma|Stage_IV_Oral_Cavity_Squamous_Cell_Carcinoma	Stage IVB Oral Cavity Squamous Cell Carcinoma|Stage IVB Epidermoid Carcinoma of Mouth|Stage IVB Epidermoid Carcinoma of Oral Cavity|Stage IVB Epidermoid Carcinoma of the Mouth|Stage IVB Epidermoid Carcinoma of the Oral Cavity|Stage IVB Mouth Epidermoid Carcinoma|Stage IVB Mouth Squamous Cell Carcinoma|Stage IVB Oral Cavity Epidermoid Carcinoma|Stage IVB Squamous Cell Carcinoma of Mouth|Stage IVB Squamous Cell Carcinoma of Oral Cavity|Stage IVB Squamous Cell Carcinoma of the Mouth|Stage IVB Squamous Cell Carcinoma of the Oral Cavity
C6059	Stage_IVC_Oral_Cavity_Squamous_Cell_Carcinoma	Stage_IVC_Oral_Cavity_Carcinoma|Stage_IV_Oral_Cavity_Squamous_Cell_Carcinoma	Stage IVC Oral Cavity Squamous Cell Carcinoma|Stage IVC Epidermoid Carcinoma of Mouth|Stage IVC Epidermoid Carcinoma of Oral Cavity|Stage IVC Epidermoid Carcinoma of the Mouth|Stage IVC Epidermoid Carcinoma of the Oral Cavity|Stage IVC Mouth Epidermoid Carcinoma|Stage IVC Mouth Squamous Cell Carcinoma|Stage IVC Oral Cavity Epidermoid Carcinoma|Stage IVC Squamous Cell Carcinoma of Mouth|Stage IVC Squamous Cell Carcinoma of Oral Cavity|Stage IVC Squamous Cell Carcinoma of the Mouth|Stage IVC Squamous Cell Carcinoma of the Oral Cavity
C6060	Recurrent_Oral_Cavity_Squamous_Cell_Carcinoma	Oral_Cavity_Squamous_Cell_Carcinoma|Recurrent_Oral_Cavity_Carcinoma	Recurrent Oral Cavity Squamous Cell Carcinoma|Recurrent Epidermoid Carcinoma of Mouth|Recurrent Epidermoid Carcinoma of Oral Cavity|Recurrent Epidermoid Carcinoma of the Mouth|Recurrent Epidermoid Carcinoma of the Oral Cavity|Recurrent Mouth Epidermoid Carcinoma|Recurrent Mouth Squamous Cell Carcinoma|Recurrent Oral Cavity Epidermoid Carcinoma|Recurrent Squamous Cell Carcinoma of Mouth|Recurrent Squamous Cell Carcinoma of Oral Cavity|Recurrent Squamous Cell Carcinoma of the Mouth|Recurrent Squamous Cell Carcinoma of the Oral Cavity|Relapsed Epidermoid Carcinoma of Mouth|Relapsed Epidermoid Carcinoma of Oral Cavity|Relapsed Epidermoid Carcinoma of the Mouth|Relapsed Epidermoid Carcinoma of the Oral Cavity|Relapsed Mouth Epidermoid Carcinoma|Relapsed Mouth Squamous Cell Carcinoma|Relapsed Oral Cavity Epidermoid Carcinoma|Relapsed Oral Cavity Squamous Cell Carcinoma|Relapsed Squamous Cell Carcinoma of Mouth|Relapsed Squamous Cell Carcinoma of Oral Cavity|Relapsed Squamous Cell Carcinoma of the Mouth|Relapsed Squamous Cell Carcinoma of the Oral Cavity
C6061	Malignant_Anterior_Tongue_Neoplasm	Anterior_Tongue_Neoplasm|Malignant_Oral_Cavity_Neoplasm|Malignant_Tongue_Neoplasm	Malignant Anterior Tongue Neoplasm|Malignant Anterior Tongue Tumor|Malignant Neoplasm of Anterior Tongue|Malignant Neoplasm of the Anterior Tongue|Malignant Tumor of Anterior Tongue|Malignant Tumor of the Anterior Tongue
C6062	Anterior_Tongue_Neoplasm	Tongue_Neoplasm	Anterior Tongue Neoplasm|Anterior Tongue Tumor|Neoplasm of Anterior Tongue|Neoplasm of the Anterior Tongue|Tumor of Anterior Tongue|Tumor of the Anterior Tongue
C6063	Benign_Anterior_Tongue_Neoplasm	Anterior_Tongue_Neoplasm|Benign_Oral_Cavity_Neoplasm|Benign_Tongue_Neoplasm	Benign Anterior Tongue Neoplasm|Benign Anterior Tongue Tumor|Benign Neoplasm of Anterior Tongue|Benign Neoplasm of the Anterior Tongue|Benign Tumor of Anterior Tongue|Benign Tumor of the Anterior Tongue
C6064	Maxillary_Sinus_Squamous_Cell_Carcinoma	Maxillary_Sinus_Carcinoma|Paranasal_Sinus_Squamous_Cell_Carcinoma	Maxillary Sinus Squamous Cell Carcinoma|Epidermoid Carcinoma of Maxillary Antrum|Epidermoid Carcinoma of Maxillary Sinus|Epidermoid Carcinoma of Maxillofacial Sinus|Epidermoid Carcinoma of the Maxillary Antrum|Epidermoid Carcinoma of the Maxillary Sinus|Epidermoid Carcinoma of the Maxillofacial Sinus|Maxillary Antrum Epidermoid Carcinoma|Maxillary Antrum Squamous Cell Carcinoma|Maxillary Sinus Epidermoid Carcinoma|Maxillofacial Sinus Epidermoid Carcinoma|Maxillofacial Sinus Squamous Cell Carcinoma|Squamous Cell Carcinoma of Maxillary Antrum|Squamous Cell Carcinoma of Maxillary Sinus|Squamous Cell Carcinoma of Maxillofacial Sinus|Squamous Cell Carcinoma of the Maxillary Antrum|Squamous Cell Carcinoma of the Maxillary Sinus|Squamous Cell Carcinoma of the Maxillofacial Sinus
C6065	Ethmoid_Sinus_Squamous_Cell_Carcinoma	Malignant_Ethmoid_Sinus_Neoplasm|Paranasal_Sinus_Squamous_Cell_Carcinoma	Ethmoid Sinus Squamous Cell Carcinoma|Epidermoid Carcinoma of Ethmoid Sinus|Epidermoid Carcinoma of Ethmoidal Sinus|Epidermoid Carcinoma of the Ethmoid Sinus|Epidermoid Carcinoma of the Ethmoidal Sinus|Ethmoid Sinus Epidermoid Carcinoma|Ethmoidal Sinus Epidermoid Carcinoma|Ethmoidal Sinus Squamous Cell Carcinoma|Squamous Cell Carcinoma of Ethmoid Sinus|Squamous Cell Carcinoma of Ethmoidal Sinus|Squamous Cell Carcinoma of the Ethmoid Sinus|Squamous Cell Carcinoma of the Ethmoidal Sinus
C6066	Sphenoid_Sinus_Squamous_Cell_Carcinoma	Malignant_Sphenoid_Sinus_Neoplasm|Paranasal_Sinus_Squamous_Cell_Carcinoma	Sphenoid Sinus Squamous Cell Carcinoma|Epidermoid Carcinoma of Sphenoid Sinus|Epidermoid Carcinoma of Sphenoidal Sinus|Epidermoid Carcinoma of the Sphenoid Sinus|Epidermoid Carcinoma of the Sphenoidal Sinus|Sphenoid Sinus Epidermoid Carcinoma|Sphenoidal Sinus Epidermoid Carcinoma|Sphenoidal Sinus Squamous Cell Carcinoma|Squamous Cell Carcinoma of Sphenoid Sinus|Squamous Cell Carcinoma of Sphenoidal Sinus|Squamous Cell Carcinoma of the Sphenoid Sinus|Squamous Cell Carcinoma of the Sphenoidal Sinus
C6067	Frontal_Sinus_Squamous_Cell_Carcinoma	Malignant_Frontal_Sinus_Neoplasm|Paranasal_Sinus_Squamous_Cell_Carcinoma	Frontal Sinus Squamous Cell Carcinoma|Epidermoid Carcinoma of Frontal Sinus|Epidermoid Carcinoma of the Frontal Sinus|Frontal Sinus Epidermoid Carcinoma|Squamous Cell Carcinoma of Frontal Sinus|Squamous Cell Carcinoma of the Frontal Sinus
C6068	Paranasal_Sinus_Lymphoma	Lymphoma_by_Site|Malignant_Paranasal_Sinus_Neoplasm	Paranasal Sinus Lymphoma|Accessory Sinus Lymphoma|Lymphoma of Accessory Sinus|Lymphoma of Paranasal Sinus|Lymphoma of the Accessory Sinus|Lymphoma of the Paranasal Sinus|Primary Paranasal Sinus Lymphoma
C6069	Paranasal_Sinus_Non-Hodgkin_s_Lymphoma	Non-Hodgkin_s_Lymphoma|Paranasal_Sinus_Lymphoma	Paranasal Sinus Non-Hodgkin's Lymphoma|Accessory Sinus Non-Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma of Accessory Sinus|Non-Hodgkin's Lymphoma of Paranasal Sinus|Non-Hodgkin's Lymphoma of the Accessory Sinus|Non-Hodgkin's Lymphoma of the Paranasal Sinus|Primary Paranasal Sinus Non-Hodgkin's Lymphoma
C6070	Stage_IVA_Paranasal_Sinus_Cancer	Stage_IV_Paranasal_Sinus_Cancer	Stage IVA Paranasal Sinus Cancer|Paranasal Sinus Cancer Stage IVA|Stage IVA Accessory Sinus Carcinoma|Stage IVA Carcinoma of Accessory Sinus|Stage IVA Carcinoma of Paranasal Sinus|Stage IVA Carcinoma of the Accessory Sinus|Stage IVA Carcinoma of the Paranasal Sinus|Stage IVA Paranasal Sinus Carcinoma
C6071	Stage_IVB_Paranasal_Sinus_Cancer	Stage_IV_Paranasal_Sinus_Cancer	Stage IVB Paranasal Sinus Cancer|Stage IVB Accessory Sinus Carcinoma|Stage IVB Carcinoma of Accessory Sinus|Stage IVB Carcinoma of Paranasal Sinus|Stage IVB Carcinoma of the Accessory Sinus|Stage IVB Carcinoma of the Paranasal Sinus|Stage IVB Paranasal Sinus Carcinoma
C6072	Stage_IVC_Paranasal_Sinus_Cancer	Stage_IV_Paranasal_Sinus_Cancer	Stage IVC Paranasal Sinus Cancer|Paranasal Sinus Cancer Stage IVC|Stage IVC Accessory Sinus Carcinoma|Stage IVC Carcinoma of Accessory Sinus|Stage IVC Carcinoma of Paranasal Sinus|Stage IVC Carcinoma of the Accessory Sinus|Stage IVC Carcinoma of the Paranasal Sinus|Stage IVC Paranasal Sinus Carcinoma
C6073	Paranasal_Sinus_Diffuse_Large_B-Cell_Lymphoma	Diffuse_Large_B-Cell_Lymphoma|Paranasal_Sinus_Non-Hodgkin_s_Lymphoma	Paranasal Sinus Diffuse Large B-Cell Lymphoma|Accessory Sinus Diffuse Large B-Cell Lymphoma|Diffuse Large B-Cell Lymphoma of Accessory Sinus|Diffuse Large B-Cell Lymphoma of Paranasal Sinus|Diffuse Large B-Cell Lymphoma of the Accessory Sinus|Diffuse Large B-Cell Lymphoma of the Paranasal Sinus|Primary Paranasal Sinus Diffuse Large B-Cell Lymphoma
C6074	Nasal_Cavity_Lymphoma	Lymphoma_by_Site|Malignant_Nasal_Cavity_Neoplasm	Nasal Cavity Lymphoma|Lymphoma of Nasal Cavity|Lymphoma of the Nasal Cavity|Primary Nasal Cavity Lymphoma
C6075	Nasal_Cavity_Non-Hodgkin_s_Lymphoma	Nasal_Cavity_Lymphoma|Non-Hodgkin_s_Lymphoma	Nasal Cavity Non-Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma of Nasal Cavity|Non-Hodgkin's Lymphoma of the Nasal Cavity
C6076	Recurrent_Oral_Cavity_Carcinoma	Oral_Cavity_Carcinoma|Recurrent_Head_and_Neck_Cancer	Recurrent Oral Cavity Cancer|Recurrent Carcinoma of Mouth|Recurrent Carcinoma of Oral Cavity|Recurrent Carcinoma of the Mouth|Recurrent Carcinoma of the Oral Cavity|Recurrent Mouth Carcinoma|Recurrent Oral Cavity Carcinoma|Relapsed Carcinoma of Mouth|Relapsed Carcinoma of Oral Cavity|Relapsed Carcinoma of the Mouth|Relapsed Carcinoma of the Oral Cavity|Relapsed Mouth Carcinoma|Relapsed Oral Cavity Cancer|Relapsed Oral Cavity Carcinoma
C6077	Neck_Carcinoma	Carcinoma|Malignant_Neck_Neoplasm	Neck Carcinoma|Carcinoma of Neck|Carcinoma of the Neck
C6078	Eyelid_Carcinoma	Eye_Carcinoma|Malignant_Eyelid_Neoplasm	Eyelid Carcinoma|Carcinoma of Eyelid|Carcinoma of the Eyelid
C6079	Eye_Carcinoma	Carcinoma|Malignant_Eye_Neoplasm	Eye Carcinoma|Carcinoma of Eye|Carcinoma of the Eye|Ocular Carcinoma
C6080	External_Ear_Actinic_Keratosis	Actinic_Solar_Keratosis|Benign_External_Ear_Neoplasm	External Ear Actinic Keratosis|Actinic Keratosis of External Ear|Actinic Keratosis of the External Ear
C6081	External_Ear_Carcinoma	Carcinoma|Infrequent_Neoplasm|Malignant_External_Ear_Neoplasm	External Ear Carcinoma|Carcinoma of External Ear|Carcinoma of the External Ear
C6082	External_Ear_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma|External_Ear_Carcinoma	External Ear Basal Cell Carcinoma|Basal Cell Carcinoma of External Ear|Basal Cell Carcinoma of the External Ear
C6083	External_Ear_Squamous_Cell_Carcinoma	External_Ear_Carcinoma|Head_and_Neck_Squamous_Cell_Carcinoma	External Ear Squamous Cell Carcinoma|Epidermoid Carcinoma of External Ear|Epidermoid Carcinoma of the External Ear|External Ear Epidermoid Carcinoma|Squamous Cell Carcinoma of External Ear|Squamous Cell Carcinoma of the External Ear
C6084	External_Ear_Cyst	Cyst|Eye_and_Ear_Finding	External Ear Cyst|Cyst of External Ear|Cyst of the External Ear
C6085	Middle_Ear_Paraganglioma	Jugulotympanic_Paraganglioma|Middle_Ear_Neoplasm	Middle Ear Paraganglioma|Non-Chromaffin Middle Ear Paraganglioma|Non-Chromaffin Paraganglioma of Middle Ear|Non-Chromaffin Paraganglioma of the Middle Ear|Paraganglioma of Middle Ear|Paraganglioma of the Middle Ear	A benign or malignant jugulotympanic paraganglioma arising from paraganglia in the middle ear.
C6086	Middle_Ear_Squamous_Cell_Carcinoma	Head_and_Neck_Squamous_Cell_Carcinoma|Middle_Ear_Carcinoma	Middle Ear Squamous Cell Carcinoma|Epidermoid Carcinoma of Middle Ear|Epidermoid Carcinoma of the Middle Ear|Middle Ear Epidermoid Carcinoma|Squamous Cell Carcinoma of Middle Ear|Squamous Cell Carcinoma of the Middle Ear
C6087	External_Auditory_Canal_Sebaceous_Cyst	External_Ear_Cyst|Sebaceous_Cyst	External Auditory Canal Sebaceous Cyst|Sebaceous Cyst of External Auditory Canal|Sebaceous Cyst of the External Auditory Canal
C6088	External_Auditory_Canal_Ceruminous_Adenoma	Benign_Ear_Neoplasm	External Auditory Canal Ceruminous Adenoma|Ceruminous Adenoma of External Auditory Canal|Ceruminous Adenoma of the External Auditory Canal
C6089	Middle_Ear_Carcinoma	Carcinoma|Infrequent_Neoplasm|Malignant_Middle_Ear_Neoplasm	Middle Ear Carcinoma|Carcinoma of Middle Ear|Carcinoma of the Middle Ear
C6090	Lacrimal_Gland_Malignant_Mixed_Tumor	Malignant_Lacrimal_Gland_Neoplasm|Malignant_Mixed_Neoplasm	Lacrimal Gland Malignant Mixed Tumor|Lacrimal Gland Malignant Mixed Neoplasm|Malignant Mixed Neoplasm of Lacrimal Gland|Malignant Mixed Neoplasm of the Lacrimal Gland|Malignant Mixed Tumor of Lacrimal Gland|Malignant Mixed Tumor of the Lacrimal Gland
C6091	Lacrimal_Gland_Mucoepidermoid_Carcinoma	Lacrimal_Gland_Carcinoma|Mucoepidermoid_Carcinoma	Lacrimal Gland Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Lacrimal Gland|Mucoepidermoid Carcinoma of the Lacrimal Gland
C6092	Lacrimal_Gland_Squamous_Cell_Carcinoma	Lacrimal_Gland_Carcinoma|Squamous_Cell_Carcinoma	Lacrimal Gland Squamous Cell Carcinoma|Epidermoid Carcinoma of Lacrimal Gland|Epidermoid Carcinoma of the Lacrimal Gland|Lacrimal Gland Epidermoid Carcinoma|Squamous Cell Carcinoma of Lacrimal Gland|Squamous Cell Carcinoma of the Lacrimal Gland
C6093	Corneal_Intraepithelial_Neoplasia	Corneal_Neoplasm|Squamous_Cell_Intraepithelial_Neoplasia	Corneal Intraepithelial Neoplasia|Cornea Intraepithelial Neoplasia|Intraepithelial Neoplasia of Cornea|Intraepithelial Neoplasia of the Cornea
C6094	Low_Grade_Corneal_Intraepithelial_Neoplasia	Corneal_Intraepithelial_Neoplasia|Low_Grade_Squamous_Intraepithelial_Neoplasia	Low Grade Corneal Intraepithelial Neoplasia|Grade 1 Corneal Intraepithelial Neoplasia|Grade I Corneal Intraepithelial Neoplasia
C6095	Orbit_Sarcoma	Malignant_Orbit_Neoplasm|Soft_Tissue_Sarcoma	Orbit Sarcoma|Orbital Sarcoma|Sarcoma of Orbit|Sarcoma of the Orbit
C6097	Low_Grade_Conjunctival_Intraepithelial_Neoplasia	Conjunctival_Intraepithelial_Neoplasia|Low_Grade_Squamous_Intraepithelial_Neoplasia	Low Grade Conjunctival Intraepithelial Neoplasia|Grade 1 Conjunctival Intraepithelial Neoplasia|Grade I Conjunctival Intraepithelial Neoplasia
C6098	Iris_Spindle_Cell_Melanoma	Iris_Melanoma|Spindle_Cell_Uveal_Melanoma	Iris Spindle Cell Melanoma|Spindle Cell Melanoma of Iris|Spindle Cell Melanoma of the Iris
C6099	Choroid_Spindle_Cell_Melanoma	Choroid_Melanoma|Spindle_Cell_Uveal_Melanoma	Choroid Spindle Cell Melanoma|Spindle Cell Melanoma of Choroid|Spindle Cell Melanoma of the Choroid
C6100	Intermediate_Cell_Type_Choroid_Melanoma	Choroid_Melanoma|Intermediate_Cell_Type_Uveal_Melanoma	Intermediate Cell Type Choroid Melanoma|Choroid Mixed Cell Melanoma|Mixed Cell Melanoma of Choroid|Mixed Cell Melanoma of the Choroid
C6101	Intermediate_Cell_Type_Iris_Melanoma	Intermediate_Cell_Type_Uveal_Melanoma|Iris_Melanoma	Intermediate Cell Type Iris Melanoma|Iris Mixed Cell Melanoma|Mixed Cell Melanoma of Iris|Mixed Cell Melanoma of the Iris
C6102	Choroid_Epithelioid_Cell_Melanoma	Choroid_Melanoma|Epitheliod_Cell_Uveal_Melanoma	Choroid Epithelioid Cell Melanoma|Choroidal Epithelioid Cell Melanoma|Epithelioid Cell Melanoma of Choroid|Epithelioid Cell Melanoma of the Choroid
C6103	Metastatic_Neoplasm_to_the_Iris	Malignant_Iris_Neoplasm|Metastatic_Neoplasm_to_the_Eye	Metastatic Malignant Neoplasm to the Iris|Metastatic Neoplasm to the Iris|Metastatic Tumor to the Iris
C6104	Benign_Uveal_Neoplasm	Benign_Eye_Neoplasm|Uveal_Neoplasm	Benign Uveal Neoplasm|Benign Neoplasm of Uvea|Benign Neoplasm of the Uvea|Benign Tumor of Uvea|Benign Tumor of the Uvea|Benign Uvea Neoplasm|Benign Uvea Tumor|Benign Uveal Tumor
C6105	Malignant_Uveal_Neoplasm	Malignant_Eye_Neoplasm|Uveal_Neoplasm	Malignant Uveal Neoplasm|Malignant Neoplasm of Uvea|Malignant Neoplasm of the Uvea|Malignant Tumor of Uvea|Malignant Tumor of the Uvea|Malignant Uvea Neoplasm|Malignant Uvea Tumor|Malignant Uveal Tumor
C6106	Stage_I_Retinoblastoma	Retinoblastoma	Stage I Retinoblastoma
C6107	Stage_IA_Retinoblastoma	Stage_I_Retinoblastoma	Stage IA Retinoblastoma
C6108	Stage_IB_Retinoblastoma	Stage_I_Retinoblastoma	Stage IB Retinoblastoma
C6109	Stage_II_Retinoblastoma	Retinoblastoma	Stage II Retinoblastoma
C6110	Stage_IIA_Retinoblastoma	Stage_II_Retinoblastoma	Stage IIA Retinoblastoma
C6111	Stage_IIB_Retinoblastoma	Stage_II_Retinoblastoma	Stage IIB Retinoblastoma
C6112	Stage_IIC_Retinoblastoma	Stage_II_Retinoblastoma	Stage IIC Retinoblastoma
C6113	Stage_III_Retinoblastoma	Retinoblastoma	Stage III Retinoblastoma
C6114	Stage_IIIA_Retinoblastoma	Stage_III_Retinoblastoma	Stage IIIA Retinoblastoma
C6115	Stage_IIIB_Retinoblastoma	Stage_III_Retinoblastoma	Stage IIIB Retinoblastoma
C6116	Stage_IV_Retinoblastoma	Retinoblastoma	Stage IV Retinoblastoma
C6117	Ciliary_Body_Spindle_Cell_Melanoma	Ciliary_Body_Melanoma|Spindle_Cell_Uveal_Melanoma	Ciliary Body Spindle Cell Melanoma|Spindle Cell Melanoma of Ciliary Body|Spindle Cell Melanoma of the Ciliary Body
C6118	Intermediate_Cell_Type_Ciliary_Body_Melanoma	Ciliary_Body_Melanoma|Intermediate_Cell_Type_Uveal_Melanoma	Intermediate Cell Type Ciliary Body Melanoma|Ciliary Body Mixed Cell Melanoma|Mixed Cell Melanoma of Ciliary Body|Mixed Cell Melanoma of the Ciliary Body
C6119	Ciliary_Body_Epithelioid_Cell_Melanoma	Ciliary_Body_Melanoma|Epitheliod_Cell_Uveal_Melanoma	Ciliary Body Epithelioid Cell Melanoma|Epithelioid Cell Melanoma of Ciliary Body|Epithelioid Cell Melanoma of the Ciliary Body
C6120	Conjunctival_Intraepithelial_Neoplasia	Conjunctival_Neoplasm|Squamous_Cell_Intraepithelial_Neoplasia	Conjunctival Intraepithelial Neoplasia|Conjunctiva Intraepithelial Neoplasia|Intraepithelial Neoplasia of Conjunctiva|Intraepithelial Neoplasia of the Conjunctiva
C6121	Stage_0_Laryngeal_Squamous_Cell_Carcinoma	Laryngeal_Squamous_Cell_Carcinoma|Stage_0_Laryngeal_Cancer|Stage_0_Squamous_Cell_Carcinoma	Stage 0 Laryngeal Squamous Cell Carcinoma|Epidermoid Carcinoma in situ of Larynx|Epidermoid Carcinoma in situ of the Larynx|Laryngeal Epidermoid Carcinoma in situ|Laryngeal Squamous Cell Carcinoma in situ|Larynx Epidermoid Carcinoma in situ|Larynx Squamous Cell Carcinoma in situ|Squamous Cell Carcinoma in situ of Larynx|Squamous Cell Carcinoma in situ of the Larynx|Stage 0 Epidermoid Carcinoma of Larynx|Stage 0 Epidermoid Carcinoma of the Larynx|Stage 0 Laryngeal Epidermoid Carcinoma|Stage 0 Larynx Epidermoid Carcinoma|Stage 0 Larynx Squamous Cell Carcinoma|Stage 0 Squamous Cell Carcinoma of Larynx|Stage 0 Squamous Cell Carcinoma of the Larynx
C6122	Stage_IVA_Laryngeal_Squamous_Cell_Carcinoma	Stage_IVA_Laryngeal_Cancer|Stage_IV_Laryngeal_Squamous_Cell_Carcinoma	Stage IVA Laryngeal Squamous Cell Carcinoma|Stage IVA Epidermoid Carcinoma of Larynx|Stage IVA Epidermoid Carcinoma of the Larynx|Stage IVA Laryngeal Epidermoid Carcinoma|Stage IVA Larynx Epidermoid Carcinoma|Stage IVA Larynx Squamous Cell Carcinoma|Stage IVA Squamous Cell Carcinoma of Larynx|Stage IVA Squamous Cell Carcinoma of the Larynx
C6123	Stage_IVB_Laryngeal_Squamous_Cell_Carcinoma	Stage_IVB_Laryngeal_Cancer|Stage_IV_Laryngeal_Squamous_Cell_Carcinoma	Stage IVB Laryngeal Squamous Cell Carcinoma|Stage IVB Epidermoid Carcinoma of Larynx|Stage IVB Epidermoid Carcinoma of the Larynx|Stage IVB Laryngeal Epidermoid Carcinoma|Stage IVB Larynx Epidermoid Carcinoma|Stage IVB Larynx Squamous Cell Carcinoma|Stage IVB Squamous Cell Carcinoma of Larynx|Stage IVB Squamous Cell Carcinoma of the Larynx
C6124	Stage_IVC_Laryngeal_Squamous_Cell_Carcinoma	Stage_IVC_Laryngeal_Cancer|Stage_IV_Laryngeal_Squamous_Cell_Carcinoma	Stage IVC Laryngeal Squamous Cell Carcinoma|Stage IVC Epidermoid Carcinoma of Larynx|Stage IVC Epidermoid Carcinoma of the Larynx|Stage IVC Laryngeal Epidermoid Carcinoma|Stage IVC Larynx Epidermoid Carcinoma|Stage IVC Larynx Squamous Cell Carcinoma|Stage IVC Squamous Cell Carcinoma of Larynx|Stage IVC Squamous Cell Carcinoma of the Larynx
C6125	Stage_IVC_Laryngeal_Verrucous_Carcinoma	Stage_IVC_Laryngeal_Squamous_Cell_Carcinoma|Stage_IV_Laryngeal_Verrucous_Carcinoma	Stage IVC Laryngeal Verrucous Carcinoma|Stage IVC Larynx Verrucous Carcinoma|Stage IVC Verrucous Carcinoma of Larynx|Stage IVC Verrucous Carcinoma of the Larynx
C6126	Stage_IVB_Laryngeal_Verrucous_Carcinoma	Stage_IVB_Laryngeal_Squamous_Cell_Carcinoma|Stage_IV_Laryngeal_Verrucous_Carcinoma	Stage IVB Laryngeal Verrucous Carcinoma|Stage IVB Larynx Verrucous Carcinoma|Stage IVB Verrucous Carcinoma of Larynx|Stage IVB Verrucous Carcinoma of the Larynx
C6127	Stage_IVA_Laryngeal_Verrucous_Carcinoma	Stage_IVA_Laryngeal_Squamous_Cell_Carcinoma|Stage_IV_Laryngeal_Verrucous_Carcinoma	Stage IVA Laryngeal Verrucous Carcinoma|Stage IVA Larynx Verrucous Carcinoma|Stage IVA Verrucous Carcinoma of Larynx|Stage IVA Verrucous Carcinoma of the Larynx
C6128	Stage_0_Laryngeal_Verrucous_Carcinoma	Laryngeal_Verrucous_Carcinoma|Stage_0_Laryngeal_Squamous_Cell_Carcinoma	Stage 0 Laryngeal Verrucous Carcinoma|Laryngeal Verrucous Carcinoma in situ|Larynx Verrucous Carcinoma in situ|Stage 0 Larynx Verrucous Carcinoma|Stage 0 Verrucous Carcinoma of Larynx|Stage 0 Verrucous Carcinoma of the Larynx|Verrucous Carcinoma in situ of Larynx|Verrucous Carcinoma in situ of the Larynx
C6129	Lacrimal_Gland_Carcinoma	Eye_Carcinoma|Malignant_Lacrimal_Gland_Neoplasm	Lacrimal Gland Carcinoma|Carcinoma of Lacrimal Gland|Carcinoma of the Lacrimal Gland
C6130	Stage_IVC_Hypopharyngeal_Squamous_Cell_Carcinoma	Stage_IVC_Hypopharyngeal_Carcinoma|Stage_IV_Hypopharyngeal_Squamous_Cell_Carcinoma	Stage IVC Hypopharyngeal Squamous Cell Carcinoma|Stage IVC Epidermoid Carcinoma of Hypopharynx|Stage IVC Epidermoid Carcinoma of the Hypopharynx|Stage IVC Hypopharyngeal Epidermoid Carcinoma|Stage IVC Hypopharynx Epidermoid Carcinoma|Stage IVC Hypopharynx Squamous Cell Carcinoma|Stage IVC Squamous Cell Carcinoma of Hypopharynx|Stage IVC Squamous Cell Carcinoma of the Hypopharynx
C6131	Stage_IVB_Hypopharyngeal_Squamous_Cell_Carcinoma	Stage_IVB_Hypopharyngeal_Carcinoma|Stage_IV_Hypopharyngeal_Squamous_Cell_Carcinoma	Stage IVB Hypopharyngeal Squamous Cell Carcinoma|Stage IVB Epidermoid Carcinoma of Hypopharynx|Stage IVB Epidermoid Carcinoma of the Hypopharynx|Stage IVB Hypopharyngeal Epidermoid Carcinoma|Stage IVB Hypopharynx Epidermoid Carcinoma|Stage IVB Hypopharynx Squamous Cell Carcinoma|Stage IVB Squamous Cell Carcinoma of Hypopharynx|Stage IVB Squamous Cell Carcinoma of the Hypopharynx
C6132	Stage_IVA_Hypopharyngeal_Squamous_Cell_Carcinoma	Stage_IVA_Hypopharyngeal_Carcinoma|Stage_IV_Hypopharyngeal_Squamous_Cell_Carcinoma	Stage IVA Hypopharyngeal Squamous Cell Carcinoma|Stage IVA Epidermoid Carcinoma of Hypopharynx|Stage IVA Epidermoid Carcinoma of the Hypopharynx|Stage IVA Hypopharyngeal Epidermoid Carcinoma|Stage IVA Hypopharynx Epidermoid Carcinoma|Stage IVA Hypopharynx Squamous Cell Carcinoma|Stage IVA Squamous Cell Carcinoma of Hypopharynx|Stage IVA Squamous Cell Carcinoma of the Hypopharynx
C6133	Stage_I_Thyroid_Medullary_Carcinoma	Medullary_Thyroid_Carcinoma	Stage I Thyroid Gland Medullary Carcinoma|Stage I Medullary Carcinoma of Thyroid|Stage I Medullary Carcinoma of Thyroid Gland|Stage I Medullary Carcinoma of the Thyroid|Stage I Medullary Carcinoma of the Thyroid Gland|Stage I Medullary Thyroid Gland Carcinoma|Stage I Thyroid Medullary Carcinoma
C6134	Stage_II_Thyroid_Medullary_Carcinoma	Medullary_Thyroid_Carcinoma	Stage II Thyroid Gland Medullary Carcinoma|Stage II Medullary Carcinoma of Thyroid|Stage II Medullary Carcinoma of Thyroid Gland|Stage II Medullary Carcinoma of the Thyroid|Stage II Medullary Carcinoma of the Thyroid Gland|Stage II Medullary Thyroid Gland Carcinoma|Stage II Thyroid Medullary Carcinoma
C6135	Stage_III_Thyroid_Medullary_Carcinoma	Medullary_Thyroid_Carcinoma	Stage III Thyroid Gland Medullary Carcinoma|Stage III Medullary Carcinoma of Thyroid|Stage III Medullary Carcinoma of Thyroid Gland|Stage III Medullary Carcinoma of the Thyroid|Stage III Medullary Carcinoma of the Thyroid Gland|Stage III Medullary Thyroid Gland Carcinoma|Stage III Thyroid Medullary Carcinoma
C6136	Stage_IV_Thyroid_Medullary_Carcinoma	Medullary_Thyroid_Carcinoma	Stage IV Thyroid Gland Medullary Carcinoma|Stage IV Medullary Carcinoma of Thyroid|Stage IV Medullary Carcinoma of Thyroid Gland|Stage IV Medullary Carcinoma of the Thyroid|Stage IV Medullary Carcinoma of the Thyroid Gland|Stage IV Medullary Thyroid Gland Carcinoma|Stage IV Thyroid Medullary Carcinoma
C6137	Stage_IVA_Nasopharyngeal_Squamous_Cell_Carcinoma	Stage_IVA_Nasopharyngeal_Carcinoma|Stage_IV_Nasopharyngeal_Squamous_Cell_Carcinoma	Stage IVA Nasopharyngeal Squamous Cell Carcinoma|Stage IVA Epidermoid Carcinoma of Nasopharynx|Stage IVA Epidermoid Carcinoma of the Nasopharynx|Stage IVA Nasopharyngeal Epidermoid Carcinoma|Stage IVA Nasopharynx Epidermoid Carcinoma|Stage IVA Nasopharynx Squamous Cell Carcinoma|Stage IVA Squamous Cell Carcinoma of Nasopharynx|Stage IVA Squamous Cell Carcinoma of the Nasopharynx
C6138	Stage_IVB_Nasopharyngeal_Squamous_Cell_Carcinoma	Stage_IVB_Nasopharyngeal_Carcinoma|Stage_IV_Nasopharyngeal_Squamous_Cell_Carcinoma	Stage IVB Nasopharyngeal Squamous Cell Carcinoma|Stage IVB Epidermoid Carcinoma of Nasopharynx|Stage IVB Epidermoid Carcinoma of the Nasopharynx|Stage IVB Nasopharyngeal Epidermoid Carcinoma|Stage IVB Nasopharynx Epidermoid Carcinoma|Stage IVB Nasopharynx Squamous Cell Carcinoma|Stage IVB Squamous Cell Carcinoma of Nasopharynx|Stage IVB Squamous Cell Carcinoma of the Nasopharynx
C6139	Stage_IVB_Oropharyngeal_Squamous_Cell_Carcinoma	Stage_IVB_Oropharyngeal_Carcinoma|Stage_IV_Oropharyngeal_Squamous_Cell_Carcinoma	Stage IVB Oropharyngeal Squamous Cell Carcinoma|Stage IVB Epidermoid Carcinoma of Oropharynx|Stage IVB Epidermoid Carcinoma of the Oropharynx|Stage IVB Oropharyngeal Epidermoid Carcinoma|Stage IVB Oropharynx Epidermoid Carcinoma|Stage IVB Oropharynx Squamous Cell Carcinoma|Stage IVB Squamous Cell Carcinoma of Oropharynx|Stage IVB Squamous Cell Carcinoma of the Oropharynx
C6140	Stage_IVC_Oropharyngeal_Squamous_Cell_Carcinoma	Stage_IVC_Oropharyngeal_Carcinoma|Stage_IV_Oropharyngeal_Squamous_Cell_Carcinoma	Stage IVC Oropharyngeal Squamous Cell Carcinoma|Stage IVC Epidermoid Carcinoma of Oropharynx|Stage IVC Epidermoid Carcinoma of the Oropharynx|Stage IVC Oropharyngeal Epidermoid Carcinoma|Stage IVC Oropharynx Epidermoid Carcinoma|Stage IVC Oropharynx Squamous Cell Carcinoma|Stage IVC Squamous Cell Carcinoma of Oropharynx|Stage IVC Squamous Cell Carcinoma of the Oropharynx
C6141	Stage_IVA_Oropharyngeal_Squamous_Cell_Carcinoma	Stage_IVA_Oropharyngeal_Carcinoma|Stage_IV_Oropharyngeal_Squamous_Cell_Carcinoma	Stage IVA Oropharyngeal Squamous Cell Carcinoma|Stage IVA Epidermoid Carcinoma of Oropharynx|Stage IVA Epidermoid Carcinoma of the Oropharynx|Stage IVA Oropharyngeal Epidermoid Carcinoma|Stage IVA Oropharynx Epidermoid Carcinoma|Stage IVA Oropharynx Squamous Cell Carcinoma|Stage IVA Squamous Cell Carcinoma of Oropharynx|Stage IVA Squamous Cell Carcinoma of the Oropharynx
C6142	Renal_Pelvis_Carcinoma	Malignant_Renal_Pelvis_Neoplasm|Renal_Carcinoma	Renal Pelvis Carcinoma|Carcinoma of Kidney Pelvis|Carcinoma of Renal Pelvis|Carcinoma of the Kidney Pelvis|Carcinoma of the Renal Pelvis|Kidney Pelvis Carcinoma	A carcinoma arising in the renal pelvis.  The majority of renal pelvis carcinomas are transitional cell and less frequently squamous cell carcinomas.  --2003
C6143	Renal_Pelvis_Adenocarcinoma	Adenocarcinoma|Renal_Pelvis_Carcinoma	Renal Pelvis Adenocarcinoma|Adenocarcinoma of Kidney Pelvis|Adenocarcinoma of Renal Pelvis|Adenocarcinoma of the Kidney Pelvis|Adenocarcinoma of the Renal Pelvis|Kidney Pelvis Adenocarcinoma
C6144	Stage_I_Renal_Pelvis_Carcinoma	Renal_Pelvis_Carcinoma|Stage_I_Renal_Pelvis_and_Ureter_Carcinoma	Stage I Renal Pelvis Carcinoma|Stage I Carcinoma of Renal Pelvis|Stage I Carcinoma of the Renal Pelvis	Stage I includes: T1, M0, M0.  T1: Tumor invades subepithelial connective tissue.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003
C6145	Stage_II_Renal_Pelvis_Carcinoma	Renal_Pelvis_Carcinoma|Stage_II_Renal_Pelvis_and_Ureter_Carcinoma	Stage II Renal Pelvis Carcinoma|Stage II Carcinoma of Renal Pelvis|Stage II Carcinoma of the Renal Pelvis	Stage II includes: T2, N0, M0.  T2: Tumor invades muscularis.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003
C6146	Stage_III_Renal_Pelvis_Carcinoma	Renal_Pelvis_Carcinoma|Stage_III_Renal_Pelvis_and_Ureter_Carcinoma	Stage III Renal Pelvis Carcinoma|Stage III Carcinoma of Renal Pelvis|Stage III Carcinoma of the Renal Pelvis	Stage III includes: T3, N0, M0.  T3: Tumor invades beyond muscularis into peripelvic fat or the renal parenchyma.  N0: No lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003
C6147	Stage_IV_Renal_Pelvis_Carcinoma	Renal_Pelvis_Carcinoma|Stage_IV_Renal_Pelvis_and_Ureter_Carcinoma	Stage IV Renal Pelvis Carcinoma|Stage IV Carcinoma of Renal Pelvis|Stage IV Carcinoma of the Renal Pelvis	Stage IV includes: (T4, N0, M0); (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades adjacent organs, or through the kidney into perinephric fat.  N0: No lymph node metastasis.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in single lymph node, more than 2 cm but not more than 5cm in greatest dimension.  N3: Metastasis in a lymph node, more than 5 cm in greatest dimension.  M0: No distant metastasis.  M1: Distant metastasis. (AJCC 6th ed.) - 2003
C6148	Renal_Pelvis_Papillary_Carcinoma	Papillary_Transitional_Cell_Carcinoma|Renal_Pelvis_Papillary_Neoplasm|Renal_Pelvis_Transitional_Cell_Carcinoma	Renal Pelvis Papillary Urothelial Carcinoma|Kidney Pelvis Papillary Carcinoma|Papillary Carcinoma of Kidney Pelvis|Papillary Carcinoma of Renal Pelvis|Papillary Carcinoma of the Kidney Pelvis|Papillary Carcinoma of the Renal Pelvis
C6149	Stage_0_Ureter_Cancer	Stage_0_Renal_Pelvis_and_Ureter_Carcinoma|Ureter_Carcinoma	Stage 0 Ureter Cancer|Stage 0 Carcinoma of Ureter|Stage 0 Carcinoma of the Ureter|Stage 0 Ureter Carcinoma|Stage 0 Ureteral Carcinoma|Ureter Cancer Stage 0
C6150	Stage_I_Ureter_Cancer	Stage_I_Renal_Pelvis_and_Ureter_Carcinoma|Ureter_Carcinoma	Stage I Ureter Cancer|Stage I Carcinoma of Ureter|Stage I Carcinoma of the Ureter|Stage I Ureter Carcinoma|Stage I Ureteral Carcinoma|Ureter Cancer Stage I
C6151	Stage_II_Ureter_Cancer	Stage_II_Renal_Pelvis_and_Ureter_Carcinoma|Ureter_Carcinoma	Stage II Ureter Cancer|Stage II Carcinoma of Ureter|Stage II Carcinoma of the Ureter|Stage II Ureter Carcinoma|Stage II Ureteral Carcinoma|Ureter Cancer Stage II
C6152	Stage_III_Ureter_Cancer	Stage_III_Renal_Pelvis_and_Ureter_Carcinoma|Ureter_Carcinoma	Stage III Ureter Cancer|Stage III Carcinoma of Ureter|Stage III Carcinoma of the Ureter|Stage III Ureter Carcinoma|Stage III Ureteral Carcinoma|Ureter Cancer Stage III
C6153	Stage_IV_Ureter_Cancer	Stage_IV_Renal_Pelvis_and_Ureter_Carcinoma|Ureter_Carcinoma	Stage IV Ureter Cancer|Stage IV Carcinoma of Ureter|Stage IV Carcinoma of the Ureter|Stage IV Ureter Carcinoma|Stage IV Ureteral Carcinoma|Ureter Cancer Stage IV
C6154	Ureter_Squamous_Cell_Carcinoma	Squamous_Cell_Carcinoma|Ureter_Carcinoma	Ureter Squamous Cell Carcinoma|Epidermoid Carcinoma of Ureter|Epidermoid Carcinoma of the Ureter|Squamous Cell Carcinoma of Ureter|Squamous Cell Carcinoma of the Ureter|Ureter Epidermoid Carcinoma|Ureteral Epidermoid Carcinoma|Ureteral Squamous Cell Carcinoma
C6155	Ureter_Adenocarcinoma	Adenocarcinoma|Ureter_Carcinoma	Ureter Adenocarcinoma|Adenocarcinoma of Ureter|Adenocarcinoma of the Ureter|Ureteral Adenocarcinoma
C6156	Ureter_Transitional_Cell_Carcinoma_with_Squamous_Differentiation	Infiltrating_Renal_Pelvis_and_Ureter_Urothelial_Carcinoma|Ureter_Transitional_Cell_Carcinoma	Infiltrating Ureter Urothelial Carcinoma with Squamous Differentiation|Transitional Cell Carcinoma of Ureter with Squamous Differentiation|Transitional Cell Carcinoma of the Ureter with Squamous Differentiation|Ureteral Transitional Cell Carcinoma with Squamous Differentiation
C6157	Ureter_Transitional_Cell_Carcinoma_with_Glandular_Differentiation	Infiltrating_Renal_Pelvis_and_Ureter_Urothelial_Carcinoma|Ureter_Transitional_Cell_Carcinoma	Infiltrating Ureter Urothelial Carcinoma with Glandular Differentiation|Transitional Cell Carcinoma of Ureter with Glandular Differentiation|Transitional Cell Carcinoma of the Ureter with Glandular Differentiation|Ureteral Transitional Cell Carcinoma with Glandular Differentiation
C6158	Ureter_Transitional_Cell_Carcinoma_with_Mixed_Differentiation	Infiltrating_Renal_Pelvis_and_Ureter_Urothelial_Carcinoma|Ureter_Transitional_Cell_Carcinoma	Infiltrating Ureter Urothelial Carcinoma with Mixed Differentiation|Transitional Cell Carcinoma of Ureter with Mixed Differentiation|Transitional Cell Carcinoma of the Ureter with Mixed Differentiation|Ureteral Transitional Cell Carcinoma with Mixed Differentiation
C6159	Undifferentiated_Ureter_Carcinoma	Undifferentiated_Carcinoma|Ureter_Carcinoma	Undifferentiated Ureter Carcinoma|Anaplastic Carcinoma of Ureter|Anaplastic Carcinoma of the Ureter|Anaplastic Ureter Carcinoma|Anaplastic Ureteral Carcinoma|Undifferentiated Carcinoma of Ureter|Undifferentiated Carcinoma of the Ureter|Undifferentiated Ureteral Carcinoma
C6160	Ureter_Papilloma	Benign_Ureter_Neoplasm|Urothelial_Papilloma	Ureter Urothelial Papilloma
C6161	Ureter_Leiomyoma	Benign_Ureter_Neoplasm|Leiomyoma	Ureter Leiomyoma|Leiomyoma of Ureter|Leiomyoma of the Ureter|Ureteral Leiomyoma
C6162	Ureter_Schwannoma	Benign_Ureter_Neoplasm|Peripheral_Nerve_Schwannoma	Ureter Schwannoma|Neurilemmoma of Ureter|Neurilemmoma of the Ureter|Schwannoma of Ureter|Schwannoma of the Ureter|Ureter Neurilemmoma|Ureteral Neurilemmoma|Ureteral Schwannoma
C6163	Bladder_Signet_Ring_Cell_Adenocarcinoma	Bladder_Adenocarcinoma|Signet_Ring_Cell_Carcinoma	Bladder Signet Ring Cell Adenocarcinoma|Signet Ring Cell Adenocarcinoma of Bladder|Signet Ring Cell Adenocarcinoma of Urinary Bladder|Signet Ring Cell Adenocarcinoma of the Bladder|Signet Ring Cell Adenocarcinoma of the Urinary Bladder|Urinary Bladder Signet Ring Adenocarcinoma
C6164	Bladder_Lymphoma	Lymphoma_by_Site|Malignant_Bladder_Neoplasm	Bladder Lymphoma|Lymphoma of Bladder|Lymphoma of Urinary Bladder|Lymphoma of the Bladder|Lymphoma of the Urinary Bladder|Primary Bladder Lymphoma|Urinary Bladder Lymphoma
C6165	Urethral_Squamous_Cell_Carcinoma	Squamous_Cell_Carcinoma|Urethral_Carcinoma	Urethral Squamous Cell Carcinoma|Epidermoid Carcinoma of Urethra|Epidermoid Carcinoma of the Urethra|Squamous Cell Carcinoma of Urethra|Squamous Cell Carcinoma of the Urethra|Urethra Epidermoid Carcinoma|Urethra Squamous Cell Carcinoma|Urethral Epidermoid Carcinoma
C6166	Urethral_Transitional_Cell_Carcinoma	Urethral_Carcinoma|Urothelial_Transitional_Cell_Carcinoma	Urethral Urothelial Carcinoma|Transitional Cell Carcinoma of Urethra|Transitional Cell Carcinoma of the Urethra|Urethra Transitional Cell Carcinoma|Urethral Transitional Cell Carcinoma	The most common morphologic subtype of urinary bladder carcinoma (over 90% of cases).  It arises from the transitional epithelium.  It most often affects males in their sixth and seventh decades of life.  Hematuria is the most common symptom at presentation.  Pathologic stage is the strongest predictor of survival. -- 2003
C6167	Urethral_Adenocarcinoma	Adenocarcinoma|Urethral_Carcinoma	Urethral Adenocarcinoma|Adenocarcinoma of Urethra|Adenocarcinoma of the Urethra|Urethra Adenocarcinoma
C6168	Undifferentiated_Urethral_Carcinoma	Undifferentiated_Carcinoma|Urethral_Carcinoma	Undifferentiated Urethral Carcinoma|Anaplastic Carcinoma of Urethra|Anaplastic Carcinoma of the Urethra|Anaplastic Urethra Carcinoma|Anaplastic Urethral Carcinoma|Undifferentiated Carcinoma of Urethra|Undifferentiated Carcinoma of the Urethra|Undifferentiated Urethra Carcinoma
C6169	Urethra_Condyloma_Acuminatum	Condyloma_Acuminatum|Urethra_Neoplasm	Urethral Condyloma Acuminatum|Condylomata of Urethra|Condylomata of the Urethra|Urethral Condylomata
C6170	Urethra_Fibroepithelial_Polyp	Fibroepithelial_Polyp|Non-Neoplastic_Urethra_Disorder	Urethra Fibroepithelial Polyp|Fibroepithelial Polyp of Urethra|Fibroepithelial Polyp of the Urethra|Urethral Fibroepithelial Polyp
C6171	Urethral_Leiomyoma	Benign_Urethral_Neoplasm|Leiomyoma	Urethral Leiomyoma|Leiomyoma of Urethra|Leiomyoma of the Urethra|Urethra Leiomyoma
C6172	Urethral_Clear_Cell_Adenocarcinoma	Clear_Cell_Adenocarcinoma|Urethral_Adenocarcinoma	Urethral Clear Cell Adenocarcinoma|Clear Cell Adenocarcinoma of Urethra|Clear Cell Adenocarcinoma of the Urethra|Urethra Clear Cell Adenocarcinoma	A morphologic variant of urethral adenocarcinoma characterized by the presence of tubulocystic or papillary structures lined with clear cuboidal or hobnail cells.
C6173	Urethral_Inverted_Papilloma	Inverted_Urothelial_Papilloma|Urethral_Papilloma	Urethral Inverted Papilloma|Inverted Papilloma of Urethra|Inverted Papilloma of the Urethra|Urethra Inverted Papilloma
C6174	Ureter_Inverted_Papilloma	Inverted_Urothelial_Papilloma|Ureter_Papilloma	Ureter Inverted Papilloma|Inverted Papilloma of Ureter|Inverted Papilloma of the Ureter|Ureteral Inverted Papilloma
C6175	Ureter_Lymphoma	Lymphoma_by_Site|Malignant_Ureter_Neoplasm	Ureter Lymphoma|Lymphoma of Ureter|Lymphoma of the Ureter|Primary Ureter Lymphoma|Ureteral Lymphoma
C6176	Ureter_Small_Cell_Carcinoma	Small_Cell_Carcinoma|Ureter_Carcinoma	Ureter Small Cell Carcinoma|Small Cell Carcinoma of Ureter|Small Cell Carcinoma of the Ureter|Ureteral Small Cell Carcinoma
C6177	Urinary_Bladder_Inflammatory_Myofibroblastic_Tumor	Bladder_Neoplasm|Inflammatory_Myofibroblastic_Tumor	Bladder Inflammatory Myofibroblastic Tumor|Bladder Inflammatory Myofibroblastic Neoplasm|Inflammatory Myofibroblastic Neoplasm of Bladder|Inflammatory Myofibroblastic Neoplasm of Urinary Bladder|Inflammatory Myofibroblastic Neoplasm of the Bladder|Inflammatory Myofibroblastic Neoplasm of the Urinary Bladder|Inflammatory Myofibroblastic Tumor of Bladder|Inflammatory Myofibroblastic Tumor of Urinary Bladder|Inflammatory Myofibroblastic Tumor of the Bladder|Inflammatory Myofibroblastic Tumor of the Urinary Bladder|Urinary Bladder Inflammatory Myofibroblastic Neoplasm|Urinary Bladder Inflammatory Myofibroblastic Tumor
C6178	Bladder_Leiomyoma	Benign_Bladder_Neoplasm|Leiomyoma	Bladder Leiomyoma|Leiomyoma of Bladder|Leiomyoma of Urinary Bladder|Leiomyoma of the Bladder|Leiomyoma of the Urinary Bladder|Urinary Bladder Leiomyoma
C6179	Bladder_Clear_Cell_Adenocarcinoma	Bladder_Adenocarcinoma|Clear_Cell_Adenocarcinoma	Bladder Clear Cell Adenocarcinoma|Bladder Mesonephric Adenocarcinoma|Clear Cell Adenocarcinoma of Bladder|Clear Cell Adenocarcinoma of Urinary Bladder|Clear Cell Adenocarcinoma of the Bladder|Clear Cell Adenocarcinoma of the Urinary Bladder|Urinary Bladder Clear Cell Adenocarcinoma	A rare morphologic variant of bladder adenocarcinoma characterized by the presence of malignant glandular epithelial cells and clear cells distributed in a tubulo-cystic, papillary, or diffuse pattern.  There is a female predilection.  Clinical presentation includes hematuria and dysuria.
C6180	Adult_Wilms_Tumor	Renal_Wilms_Tumor	Adult Renal Wilms' Tumor|Adenosarcoma of Adult Kidney|Adenosarcoma of the Adult Kidney|Adult Kidney Adenosarcoma|Adult Nephroblastoma|Adult Renal Adenosarcoma|Adult Renal Wilms Tumor	Adult Wilms' tumor is morphologically identical to the childhood tumor, but is exceedingly rare.
C6181	Renal_Osteosarcoma	Extraskeletal_Osteosarcoma|Renal_Sarcoma	Renal Osteosarcoma|Kidney Osteogenic Sarcoma|Kidney Osteosarcoma|Osteogenic Sarcoma of Kidney|Osteogenic Sarcoma of the Kidney|Osteosarcoma of Kidney|Osteosarcoma of the Kidney|Renal Osteogenic Sarcoma
C6182	Renal_Pelvis_Fibroepithelial_Polyp	Fibroepithelial_Polyp|Non-Neoplastic_Renal_Disorder	Renal Pelvis Fibroepithelial Polyp|Fibroepithelial Polyp of Kidney|Fibroepithelial Polyp of Kidney Pelvis|Fibroepithelial Polyp of Renal Pelvis|Fibroepithelial Polyp of the Kidney|Fibroepithelial Polyp of the Kidney Pelvis|Fibroepithelial Polyp of the Renal Pelvis|Kidney Fibroepithelial Polyp|Kidney Pelvis Fibroepithelial Polyp|Renal Fibroepithelial Polyp
C6183	Renal_Leiomyosarcoma	Leiomyosarcoma|Renal_Sarcoma	Renal Leiomyosarcoma|Kidney Leiomyosarcoma|Leiomyosarcoma of Kidney|Leiomyosarcoma of the Kidney
C6185	Renal_Liposarcoma	Liposarcoma|Renal_Sarcoma	Renal Liposarcoma|Kidney Liposarcoma|Liposarcoma of Kidney|Liposarcoma of the Kidney
C6186	Renal_Pelvis_Sarcomatoid_Transitional_Cell_Carcinoma	Infiltrating_Renal_Pelvis_and_Ureter_Urothelial_Carcinoma|Renal_Pelvis_Transitional_Cell_Carcinoma|Sarcomatoid_Transitional_Cell_Carcinoma	Infiltrating Renal Pelvis Urothelial Carcinoma, Sarcomatoid Variant|Kidney Pelvis Sarcomatoid Transitional Cell Carcinoma|Sarcomatoid Transitional Cell Carcinoma of Kidney Pelvis|Sarcomatoid Transitional Cell Carcinoma of Renal Pelvis|Sarcomatoid Transitional Cell Carcinoma of the Kidney Pelvis|Sarcomatoid Transitional Cell Carcinoma of the Renal Pelvis
C6187	Renal_Pelvis_Inverted_Papilloma	Inverted_Urothelial_Papilloma|Renal_Pelvis_Papilloma	Renal Pelvis Inverted Papilloma|Inverted Papilloma of Kidney Pelvis|Inverted Papilloma of Renal Pelvis|Inverted Papilloma of the Kidney Pelvis|Inverted Papilloma of the Renal Pelvis|Kidney Pelvis Inverted Papilloma
C6188	Stage_0_Bladder_Transitional_Cell_Carcinoma	Non-Invasive_Bladder_Urothelial_Carcinoma|Stage_0_Bladder_Cancer|Stage_0_Transitional_Cell_Carcinoma	Stage 0 Bladder Urothelial Carcinoma|Stage 0 Transitional Cell Carcinoma of Bladder|Stage 0 Transitional Cell Carcinoma of Urinary Bladder|Stage 0 Transitional Cell Carcinoma of the Bladder|Stage 0 Transitional Cell Carcinoma of the Urinary Bladder|Stage 0 Urinary Bladder Transitional Cell Carcinoma
C6191	Stage_I_Bladder_Transitional_Cell_Carcinoma	Invasive_Urothelial_Transitional_Cell_Carcinoma|Stage_I_Bladder_Cancer	Stage I Bladder Urothelial Carcinoma|Stage I Transitional Cell Carcinoma of Bladder|Stage I Transitional Cell Carcinoma of Urinary Bladder|Stage I Transitional Cell Carcinoma of the Bladder|Stage I Transitional Cell Carcinoma of the Urinary Bladder|Stage I Urinary Bladder Transitional Cell Carcinoma
C6192	Inverted_Urothelial_Papilloma	Inverted_Transitional_Cell_Papilloma|Urothelial_Papilloma	Inverted Urothelial Papilloma|Inverted Papilloma of Urinary Tract|Urinary Tract Inverted Papilloma	An endophytic lesion in the urinary tract which shares several morphologic features with urothelial papilloma.  This lesion may recur after complete excision.  Transitional cell carcinomas may arise within inverted urothelial papillomas.  -- 2003
C6193	Stage_0_Renal_Pelvis_Carcinoma	Renal_Pelvis_Carcinoma|Stage_0_Renal_Pelvis_and_Ureter_Carcinoma	Stage 0 Renal Pelvis Carcinoma|Stage 0 Carcinoma of Renal Pelvis|Stage 0 Carcinoma of the Renal Pelvis	Stage 0 includes: 0a: (Ta, N0, M0) and 0is: (Tis, N0, M0).  T0: No evidence of primary tumor.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003
C6194	Collecting_Duct_Carcinoma	Renal_Cell_Carcinoma	Carcinoma of the Collecting Ducts of Bellini|Carcinoma of Collecting Ducts of Bellini|Carcinoma of Kidney Collecting Duct|Carcinoma of Renal Collecting Duct|Carcinoma of the Kidney Collecting Duct|Carcinoma of the Renal Collecting Duct|Collecting Duct Carcinoma|Kidney Collecting Duct Carcinoma|Renal Cell Carcinoma, Collecting Duct Type|Renal Collecting Duct Carcinoma	Also known as carcinoma of the collecting ducts of Bellini, this is a rare type of renal cell carcinoma.  It arises from the collecting ducts of the renal medulla, and most authors suggest that this is an aggressive tumor. - 2003
C6195	Stage_0_Urethral_Cancer	Urethral_Carcinoma	Stage 0 Urethral Cancer|Stage 0 Carcinoma of Urethra|Stage 0 Carcinoma of the Urethra|Stage 0 Urethra Cancer|Stage 0 Urethra Carcinoma|Stage 0 Urethral Carcinoma|Urethra Cancer Stage 0
C6196	Stage_0a_Urethral_Cancer	Stage_0_Urethral_Cancer	Stage 0a Urethral Cancer|Stage 0a Carcinoma of Urethra|Stage 0a Carcinoma of the Urethra|Stage 0a Urethra Cancer|Stage 0a Urethra Carcinoma|Stage 0a Urethral Carcinoma|Urethra Cancer Stage 0a
C6197	Stage_I_Urethral_Cancer	Urethral_Carcinoma	Stage I Urethral Cancer|Stage I Carcinoma of Urethra|Stage I Carcinoma of the Urethra|Stage I Urethra Cancer|Stage I Urethra Carcinoma|Stage I Urethral Carcinoma|Urethra Cancer Stage I
C6198	Stage_II_Urethral_Cancer	Urethral_Carcinoma	Stage II Urethral Cancer|Stage II Carcinoma of Urethra|Stage II Carcinoma of the Urethra|Stage II Urethra Carcinoma|Stage II Urethral Carcinoma|Urethra Cancer Stage II
C6199	Stage_III_Urethral_Cancer	Urethral_Carcinoma	Stage III Urethral Cancer|Stage III Carcinoma of Urethra|Stage III Carcinoma of the Urethra|Stage III Urethra Cancer|Stage III Urethra Carcinoma|Stage III Urethral Carcinoma|Urethra Cancer Stage III
C6200	Stage_IV_Urethral_Cancer	Urethral_Carcinoma	Stage IV Urethral Cancer|Stage IV Carcinoma of Urethra|Stage IV Carcinoma of the Urethra|Stage IV Urethra Cancer|Stage IV Urethra Carcinoma|Stage IV Urethral Carcinoma|Urethra Cancer Stage IV
C6201	Mixed_Ureter_Carcinoma	Retired_Concepts	Mixed Ureter Carcinoma|Mixed Carcinoma of Ureter|Mixed Carcinoma of the Ureter|Mixed Ureteral Carcinoma
C6202	Stage_0a_Renal_Pelvis_Carcinoma	Renal_Pelvis_Papillary_Carcinoma|Stage_0_Renal_Pelvis_Carcinoma|Stage_0a_Renal_Pelvis_and_Ureter_Carcinoma	Stage 0a Renal Pelvis Carcinoma|Renal Pelvis Papillary Noninvasive Carcinoma|Stage 0a Carcinoma of Renal Pelvis|Stage 0a Carcinoma of the Renal Pelvis
C6203	Stage_0a_Ureter_Cancer	Stage_0_Ureter_Cancer|Stage_0a_Renal_Pelvis_and_Ureter_Carcinoma|Ureter_Transitional_Cell_Carcinoma	Stage 0a Ureter Cancer|Stage 0a Carcinoma of Ureter|Stage 0a Carcinoma of the Ureter|Stage 0a Ureter Carcinoma|Stage 0a Ureteral Carcinoma|Ureter Cancer Stage 0a|Ureter Papillary Noninvasive Carcinoma
C6204	Childhood_Central_Nervous_System_Teratoma	Central_Nervous_System_Teratoma|Childhood_Central_Nervous_System_Germ_Cell_Neoplasm	Childhood Central Nervous System Teratoma|Childhood CNS Teratoma|Childhood Teratoma of CNS|Childhood Teratoma of Central Nervous System|Childhood Teratoma of the CNS|Childhood Teratoma of the Central Nervous System|Pediatric CNS Teratoma|Pediatric Central Nervous System Teratoma|Pediatric Teratoma of CNS|Pediatric Teratoma of Central Nervous System|Pediatric Teratoma of the CNS|Pediatric Teratoma of the Central Nervous System
C6205	Childhood_Central_Nervous_System_Germ_Cell_Neoplasm	Central_Nervous_System_Germ_Cell_Neoplasm|Childhood_Germ_Cell_Neoplasm|Malignant_Childhood_Central_Nervous_System_Neoplasm	Childhood Central Nervous System Germ Cell Tumor|Childhood CNS Germ Cell Neoplasm|Childhood CNS Germ Cell Tumor|Childhood Central Nervous System Germ Cell Neoplasm|Childhood Germ Cell Neoplasm of CNS|Childhood Germ Cell Neoplasm of Central Nervous System|Childhood Germ Cell Neoplasm of the CNS|Childhood Germ Cell Neoplasm of the Central Nervous System|Childhood Germ Cell Tumor of CNS|Childhood Germ Cell Tumor of Central Nervous System|Childhood Germ Cell Tumor of the CNS|Childhood Germ Cell Tumor of the Central Nervous System|Pediatric CNS Germ Cell Neoplasm|Pediatric CNS Germ Cell Tumor|Pediatric Central Nervous System Germ Cell Neoplasm|Pediatric Central Nervous System Germ Cell Tumor|Pediatric Germ Cell Neoplasm of CNS|Pediatric Germ Cell Neoplasm of Central Nervous System|Pediatric Germ Cell Neoplasm of the CNS|Pediatric Germ Cell Neoplasm of the Central Nervous System|Pediatric Germ Cell Tumor of CNS|Pediatric Germ Cell Tumor of Central Nervous System|Pediatric Germ Cell Tumor of the CNS|Pediatric Germ Cell Tumor of the Central Nervous System
C6206	Childhood_Central_Nervous_System_Choriocarcinoma	Central_Nervous_System_Choriocarcinoma|Childhood_Central_Nervous_System_Germ_Cell_Neoplasm|Malignant_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor	Childhood Central Nervous System Choriocarcinoma|Childhood CNS Choriocarcinoma|Choriocarcinoma of Childhood CNS|Choriocarcinoma of Childhood Central Nervous System|Choriocarcinoma of Pediatric CNS|Choriocarcinoma of Pediatric Central Nervous System|Choriocarcinoma of the Childhood CNS|Choriocarcinoma of the Childhood Central Nervous System|Choriocarcinoma of the Pediatric CNS|Choriocarcinoma of the Pediatric Central Nervous System|Pediatric CNS Choriocarcinoma|Pediatric Central Nervous System Choriocarcinoma
C6207	Childhood_Brain_Germinoma	Brain_Germinoma|Childhood_Brain_Germ_Cell_Neoplasm	Childhood Brain Germinoma|Germinoma of Childhood Brain|Germinoma of Pediatric Brain|Germinoma of the Childhood Brain|Germinoma of the Pediatric Brain|Pediatric Brain Germinoma
C6208	Childhood_Central_Nervous_System_Embryonal_Carcinoma	Childhood_Central_Nervous_System_Germ_Cell_Neoplasm|Extragonadal_Embryonal_Carcinoma	Childhood Central Nervous System Embryonal Carcinoma|Childhood CNS Embryonal Cell Carcinoma|Embryonal Carcinoma of Childhood CNS|Embryonal Carcinoma of Childhood Central Nervous System|Embryonal Carcinoma of Pediatric CNS|Embryonal Carcinoma of Pediatric Central Nervous System|Embryonal Carcinoma of the Childhood CNS|Embryonal Carcinoma of the Childhood Central Nervous System|Embryonal Carcinoma of the Pediatric CNS|Embryonal Carcinoma of the Pediatric Central Nervous System|Pediatric CNS Embryonal Cell Carcinoma|Pediatric Central Nervous System Embryonal Carcinoma
C6209	Childhood_Central_Nervous_System_Yolk_Sac_Tumor	Childhood_Central_Nervous_System_Germ_Cell_Neoplasm|Childhood_Yolk_Sac_Tumor|Malignant_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor	Childhood Central Nervous System Yolk Sac Tumor|Childhood Central Nervous System Endodermal Sinus Neoplasm|Childhood Central Nervous System Endodermal Sinus Tumor|Childhood Central Nervous System Yolk Sac Neoplasm|Pediatric Central Nervous System Endodermal Sinus Neoplasm|Pediatric Central Nervous System Endodermal Sinus Tumor|Pediatric Central Nervous System Yolk Sac Neoplasm|Pediatric Central Nervous System Yolk Sac Tumor
C6210	Soft_Palate_Benign_Granular_Cell_Tumor	Benign_Soft_Palate_Neoplasm|Oral_Cavity_Benign_Granular_Cell_Tumor	Soft Palate Benign Granular Cell Tumor|Benign Granular Cell Neoplasm of Soft Palate|Benign Granular Cell Neoplasm of the Soft Palate|Benign Granular Cell Tumor of Soft Palate|Benign Granular Cell Tumor of the Soft Palate|Soft Palate Benign Granular Cell Neoplasm
C6211	Soft_Palate_Pleomorphic_Adenoma	Benign_Soft_Palate_Neoplasm|Oral_Cavity_Pleomorphic_Adenoma	Soft Palate Pleomorphic Adenoma|Benign Mixed Tumor of Soft Palate|Benign Mixed Tumor of the Soft Palate|Pleomorphic Adenoma of Soft Palate|Pleomorphic Adenoma of the Soft Palate|Soft Palate Benign Mixed Salivary Tumor|Soft Palate Benign Mixed Tumor
C6212	Hard_Palate_Pleomorphic_Adenoma	Benign_Hard_Palate_Neoplasm|Oral_Cavity_Pleomorphic_Adenoma	Hard Palate Pleomorphic Adenoma|Benign Mixed Salivary Tumor of Hard Palate|Benign Mixed Salivary Tumor of the Hard Palate|Benign Mixed Tumor of Hard Palate|Benign Mixed Tumor of the Hard Palate|Hard Palate Benign Mixed Tumor|Pleomorphic Adenoma of Hard Palate|Pleomorphic Adenoma of the Hard Palate
C6213	Hard_Palate_Adenoid_Cystic_Carcinoma	Hard_Palate_Carcinoma|Oral_Cavity_Adenoid_Cystic_Carcinoma	Hard Palate Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Hard Palate|Adenoid Cystic Carcinoma of the Hard Palate
C6214	Hard_Palate_Mucoepidermoid_Carcinoma	Hard_Palate_Carcinoma|Oral_Cavity_Mucoepidermoid_Carcinoma	Hard Palate Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Hard Palate|Mucoepidermoid Carcinoma of the Hard Palate
C6215	Childhood_Anaplastic_Astrocytoma	Anaplastic_Astrocytoma|Childhood_Astrocytic_Tumor	Childhood Anaplastic Astrocytoma|Anaplastic Childhood Astrocytoma|Anaplastic Pediatric Astrocytoma|Grade III Childhood Astrocytic Neoplasm|Grade III Childhood Astrocytic Tumor|Grade III Childhood Astrocytoma|Grade III Pediatric Astrocytic Neoplasm|Grade III Pediatric Astrocytic Tumor|Grade III Pediatric Astrocytoma|Undifferentiated Childhood Astrocytic Neoplasm|Undifferentiated Childhood Astrocytic Tumor|Undifferentiated Childhood Astrocytoma|Undifferentiated Pediatric Astrocytic Neoplasm|Undifferentiated Pediatric Astrocytic Tumor|Undifferentiated Pediatric Astrocytoma
C6216	Childhood_Brain_Stem_Astrocytoma	Brain_Stem_Astrocytoma|Childhood_Brain_Stem_Glioma	Childhood Brain Stem Astrocytoma|Childhood Brainstem Astrocytoma	An abnormal growth of the cells that comprise the tissues of the brainstem. While the tumor may be histologically benign, it can produce great morbidity due to its location.  It presents most commonly in the first two decades of life.
C6217	Recurrent_Childhood_Brain_Stem_Astrocytoma	Childhood_Brain_Stem_Astrocytoma|Recurrent_Childhood_Brain_Stem_Glioma	Recurrent Childhood Brain Stem Astrocytoma|Recurrent Childhood Brainstem Astrocytoma
C6218	Benign_Adult_Cerebral_Neoplasm	Benign_Adult_Brain_Neoplasm|Benign_Cerebral_Neoplasm	Benign Adult Cerebral Neoplasm|Adult Benign Cerebral Neoplasms|Benign Adult Cerebral Hemispheric Neoplasm|Benign Adult Cerebral Hemispheric Tumor|Benign Adult Cerebral Tumor|Benign Adult Neoplasm of Cerebral Hemispheres|Benign Adult Neoplasm of Cerebrum|Benign Adult Neoplasm of the Cerebral Hemispheres|Benign Adult Neoplasm of the Cerebrum|Benign Adult Tumor of Cerebral Hemispheres|Benign Adult Tumor of Cerebrum|Benign Adult Tumor of the Cerebral Hemispheres|Benign Adult Tumor of the Cerebrum
C6219	Benign_Childhood_Cerebral_Neoplasm	Benign_Cerebral_Neoplasm|Benign_Childhood_Supratentorial_Neoplasm	Benign Childhood Cerebral Neoplasm|Benign Childhood Cerebral Hemispheric Neoplasm|Benign Childhood Cerebral Hemispheric Tumor|Benign Childhood Cerebral Tumor|Benign Childhood Neoplasm of Cerebral Hemispheres|Benign Childhood Neoplasm of Cerebrum|Benign Childhood Neoplasm of the Cerebral Hemispheres|Benign Childhood Neoplasm of the Cerebrum|Benign Childhood Tumor of Cerebral Hemispheres|Benign Childhood Tumor of Cerebrum|Benign Childhood Tumor of the Cerebral Hemispheres|Benign Childhood Tumor of the Cerebrum|Benign Pediatric Cerebral Hemispheric Neoplasm|Benign Pediatric Cerebral Hemispheric Tumor|Benign Pediatric Cerebral Neoplasm|Benign Pediatric Cerebral Tumor|Benign Pediatric Neoplasm of Cerebral Hemispheres|Benign Pediatric Neoplasm of Cerebrum|Benign Pediatric Neoplasm of the Cerebral Hemispheres|Benign Pediatric Neoplasm of the Cerebrum|Benign Pediatric Tumor of Cerebral Hemispheres|Benign Pediatric Tumor of Cerebrum|Benign Pediatric Tumor of the Cerebral Hemispheres|Benign Pediatric Tumor of the Cerebrum|Childhood Benign Cerebral Neoplasms
C6220	Cerebral_Hemisphere_Lipoma	Benign_Cerebral_Neoplasm|Intracranial_Lipoma	Cerebral Hemisphere Lipoma|Lipoma of Cerebral Hemisphere|Lipoma of the Cerebral Hemisphere
C6221	Thalamic_Neoplasm	Diencephalic_Neoplasm	Thalamic Neoplasm|Neoplasm of Thalamus|Neoplasm of the Thalamus|Thalamic Neoplasms|Thalamic Tumor|Thalamic Tumors|Thalamus Neoplasm|Thalamus Neoplasms|Thalamus Tumor|Thalamus Tumors|Tumor of Thalamus|Tumor of the Thalamus
C6222	Benign_Thalamic_Neoplasm	Benign_Diencephalic_Neoplasm|Thalamic_Neoplasm	Benign Thalamic Neoplasm|Benign Neoplasm of Thalamus|Benign Neoplasm of the Thalamus|Benign Thalamic Neoplasms|Benign Thalamic Tumor|Benign Thalamic Tumors|Benign Thalamus Neoplasm|Benign Thalamus Neoplasms|Benign Thalamus Tumor|Benign Thalamus Tumors|Benign Tumor of Thalamus|Benign Tumor of the Thalamus
C6224	Conjunctival_Squamous_Cell_Papilloma	Benign_Conjunctival_Neoplasm|Squamous_Cell_Papilloma	Conjunctival Squamous Papilloma|Squamous Cell Papilloma of Conjunctiva|Squamous Cell Papilloma of the Conjunctiva
C6236	Stage_IVC_Nasopharyngeal_Squamous_Cell_Carcinoma	Stage_IVC_Nasopharyngeal_Carcinoma|Stage_IV_Nasopharyngeal_Squamous_Cell_Carcinoma	Stage IVC Nasopharyngeal Squamous Cell Carcinoma|Nasopharyngeal Squamous Cell Carcinoma Stage IVC
C6237	Ethmoid_Sinus_Adenocarcinoma	Malignant_Ethmoid_Sinus_Neoplasm|Paranasal_Sinus_Adenocarcinoma	Ethmoid Sinus Adenocarcinoma|Adenocarcinoma of Ethmoid Sinus|Adenocarcinoma of the Ethmoid Sinus
C6238	Ethmoid_Sinus_Adenoid_Cystic_Carcinoma	Malignant_Ethmoid_Sinus_Neoplasm|Paranasal_Sinus_Adenoid_Cystic_Carcinoma	Ethmoid Sinus Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Ethmoid Sinus|Adenoid Cystic Carcinoma of the Ethmoid Sinus
C6239	Maxillary_Sinus_Adenoid_Cystic_Carcinoma	Maxillary_Sinus_Carcinoma|Paranasal_Sinus_Adenoid_Cystic_Carcinoma	Maxillary Sinus Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Maxillary Sinus|Adenoid Cystic Carcinoma of the Maxillary Sinus
C6240	Maxillary_Sinus_Adenocarcinoma	Maxillary_Sinus_Carcinoma|Paranasal_Sinus_Adenocarcinoma	Maxillary Sinus Adenocarcinoma|Adenocarcinoma of Maxillary Sinus|Adenocarcinoma of the Maxillary Sinus
C6241	Oropharyngeal_Adenoid_Cystic_Carcinoma	Oropharyngeal_Carcinoma|Pharyngeal_Adenoid_Cystic_Carcinoma	Oropharyngeal Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Oropharynx|Adenoid Cystic Carcinoma of the Oropharynx
C6242	Oral_Cavity_Pleomorphic_Adenoma	Oral_Cavity_Adenoma|Salivary_Gland_Pleomorphic_Adenoma	Oral Cavity Pleomorphic Adenoma|Benign Mixed Salivary Tumor of Oral Cavity|Benign Mixed Salivary Tumor of the Oral Cavity|Pleomorphic Adenoma of Oral Cavity|Pleomorphic Adenoma of the Oral Cavity
C6243	Minor_Salivary_Gland_Acinic_Cell_Carcinoma	Minor_Salivary_Gland_Adenocarcinoma|Salivary_Gland_Acinic_Cell_Carcinoma	Minor Salivary Gland Acinic Cell Carcinoma|Acinic Cell Adenocarcinoma of Minor Salivary Gland|Acinic Cell Adenocarcinoma of the Minor Salivary Gland|Acinic Cell Carcinoma of Minor Salivary Gland|Acinic Cell Carcinoma of the Minor Salivary Gland|Minor Salivary Gland Acinic Cell Adenocarcinoma
C6244	Orbit_Lymphoma	Lymphoma_by_Site|Malignant_Orbit_Neoplasm	Orbit Lymphoma|Lymphoma of Orbit|Lymphoma of the Orbit|Primary Orbit Lymphoma
C6245	Orbit_Hemangioma	Benign_Orbit_Neoplasm|Hemangioma	Orbit Hemangioma|Angioma of Orbit|Angioma of the Orbit|Hemangioma of Orbit|Hemangioma of the Orbit|Orbit Angioma
C6246	Orbit_Embryonal_Rhabdomyosarcoma	Embryonal_Rhabdomyosarcoma|Orbit_Rhabdomyosarcoma	Orbit Embryonal Rhabdomyosarcoma|Embryonal Rhabdomyosarcoma of Orbit|Embryonal Rhabdomyosarcoma of the Orbit
C6247	Orbit_Alveolar_Rhabdomyosarcoma	Alveolar_Rhabdomyosarcoma|Orbit_Rhabdomyosarcoma	Orbit Alveolar Rhabdomyosarcoma|Alveolar Rhabdomyosarcoma of Orbit|Alveolar Rhabdomyosarcoma of the Orbit
C6248	Tracheal_Lymphoma	Lymphoma_by_Site|Malignant_Tracheal_Neoplasm	Tracheal Lymphoma|Lymphoma of Trachea|Lymphoma of the Trachea|Primary Tracheal Lymphoma
C6249	Anterior_Tongue_Carcinoma	Malignant_Anterior_Tongue_Neoplasm|Tongue_Carcinoma	Anterior Tongue Carcinoma|Carcinoma of Anterior Tongue|Carcinoma of the Anterior Tongue
C6250	Anterior_Tongue_Mucoepidermoid_Carcinoma	Anterior_Tongue_Carcinoma|Mucoepidermoid_Carcinoma	Anterior Tongue Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Anterior Tongue|Mucoepidermoid Carcinoma of the Anterior Tongue
C6251	Anterior_Tongue_Adenoid_Cystic_Carcinoma	Anterior_Tongue_Carcinoma|Oral_Cavity_Adenoid_Cystic_Carcinoma	Anterior Tongue Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Anterior Tongue|Adenoid Cystic Carcinoma of the Anterior Tongue
C6252	Childhood_Brain_Anaplastic_Astrocytoma	Childhood_Anaplastic_Astrocytoma	Childhood Brain Anaplastic Astrocytoma|Anaplastic Childhood Astrocytic Neoplasm of Brain|Anaplastic Childhood Astrocytic Neoplasm of the Brain|Anaplastic Childhood Astrocytic Tumor of Brain|Anaplastic Childhood Astrocytic Tumor of the Brain|Anaplastic Childhood Astrocytoma of Brain|Anaplastic Childhood Astrocytoma of the Brain|Anaplastic Childhood Brain Astrocytic Neoplasm|Anaplastic Childhood Brain Astrocytic Tumor|Anaplastic Childhood Brain Astrocytoma|Anaplastic Pediatric Astrocytic Neoplasm of Brain|Anaplastic Pediatric Astrocytic Neoplasm of the Brain|Anaplastic Pediatric Astrocytic Tumor of Brain|Anaplastic Pediatric Astrocytic Tumor of the Brain|Anaplastic Pediatric Astrocytoma of Brain|Anaplastic Pediatric Astrocytoma of the Brain|Anaplastic Pediatric Brain Astrocytic Neoplasm|Anaplastic Pediatric Brain Astrocytic Tumor|Anaplastic Pediatric Brain Astrocytoma|Childhood Anaplastic Astrocytic Brain Neoplasm|Grade III Childhood Astrocytic Neoplasm of Brain|Grade III Childhood Astrocytic Neoplasm of the Brain|Grade III Childhood Astrocytic Tumor of Brain|Grade III Childhood Astrocytic Tumor of the Brain|Grade III Childhood Astrocytoma of Brain|Grade III Childhood Astrocytoma of the Brain|Grade III Childhood Brain Astrocytic Neoplasm|Grade III Childhood Brain Astrocytic Tumor|Grade III Childhood Brain Astrocytoma|Grade III Pediatric Astrocytic Neoplasm of Brain|Grade III Pediatric Astrocytic Neoplasm of the Brain|Grade III Pediatric Astrocytic Tumor of Brain|Grade III Pediatric Astrocytic Tumor of the Brain|Grade III Pediatric Astrocytoma of Brain|Grade III Pediatric Astrocytoma of the Brain|Grade III Pediatric Brain Astrocytic Neoplasm|Grade III Pediatric Brain Astrocytic Tumor|Grade III Pediatric Brain Astrocytoma
C6253	Childhood_Brain_Meningioma	Childhood_Meningioma|Intracranial_Meningioma	Childhood Brain Meningioma|Childhood Meningioma of Brain|Childhood Meningioma of the Brain|Pediatric Brain Meningioma|Pediatric Meningioma of Brain|Pediatric Meningioma of the Brain
C6254	Stage_IIA_Nasopharyngeal_Squamous_Cell_Carcinoma	Stage_IIA_Nasopharyngeal_Carcinoma|Stage_II_Nasopharyngeal_Squamous_Cell_Carcinoma	Stage IIA Nasopharyngeal Squamous Cell Carcinoma|Nasopharyngeal Squamous Cell Carcinoma Stage IIA
C6255	Stage_IIB_Nasopharyngeal_Squamous_Cell_Carcinoma	Stage_IIB_Nasopharyngeal_Carcinoma|Stage_II_Nasopharyngeal_Squamous_Cell_Carcinoma	Stage IIB Nasopharyngeal Squamous Cell Carcinoma|Nasopharyngeal Squamous Cell Carcinoma Stage IIB
C6256	Ovarian_Serous_Surface_Papillary_Carcinoma	Ovarian_Papillary_Neoplasm|Ovarian_Serous_Adenocarcinoma|Papillary_Serous_Cystadenocarcinoma	Ovarian Serous Surface Papillary Adenocarcinoma|Serous Surface Papillary Carcinoma of Ovary|Serous Surface Papillary Carcinoma of the Ovary
C6257	Ovarian_Endometrioid_Tumor	Endometrioid_Tumor|Ovarian_Epithelial_Neoplasm	Ovarian Endometrioid Tumor|Endometrioid Neoplasm of Ovary|Endometrioid Neoplasm of the Ovary|Ovarian Endometrioid Neoplasm
C6258	Stage_IIIA_Ovarian_Cancer	Stage_III_Ovarian_Cancer	Stage IIIA Ovarian Cancer|AJCC Stage IIIA Ovarian Cancer|FIGO Stage IIIA Cancer of Ovary|FIGO Stage IIIA Cancer of the Ovary|FIGO Stage IIIA Carcinoma of Ovary|FIGO Stage IIIA Carcinoma of the Ovary|FIGO Stage IIIA Ovarian Cancer|FIGO Stage IIIA Ovarian Carcinoma|Ovarian Cancer Stage IIIA	Stage IIIA includes: T3a, N0, M0.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor). N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C6259	Stage_IIIB_Ovarian_Cancer	Stage_III_Ovarian_Cancer	Stage IIIB Ovarian Cancer|AJCC Stage IIIB Ovarian Cancer|FIGO Stage IIIB Cancer of Ovary|FIGO Stage IIIB Cancer of the Ovary|FIGO Stage IIIB Carcinoma of Ovary|FIGO Stage IIIB Carcinoma of the Ovary|FIGO Stage IIIB Ovarian Cancer|FIGO Stage IIIB Ovarian Carcinoma|Ovarian Cancer Stage IIIB	Stage IIIB includes: T3b, N0, M0.  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C6260	Stage_IIIC_Ovarian_Cancer	Stage_III_Ovarian_Cancer	Stage IIIC Ovarian Cancer|AJCC Stage IIIC Ovarian Cancer|FIGO Stage IIIC Cancer of Ovary|FIGO Stage IIIC Cancer of the Ovary|FIGO Stage IIIC Carcinoma of Ovary|FIGO Stage IIIC Carcinoma of the Ovary|FIGO Stage IIIC Ovarian Cancer|FIGO Stage IIIC Ovarian Carcinoma|Ovarian Cancer Stage IIIC	Stage IIIC includes: (T3c, N0, M0); (Any T, N1, M0). T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C6261	Ovarian_Granulosa_Cell_Tumor	Granulosa_Cell_Tumor|Ovarian_Granulosa-Stromal_Cell_Tumor	Ovarian Granulosa Cell Tumor|Granulosa Cell Neoplasm of Ovary|Granulosa Cell Neoplasm of the Ovary|Granulosa Cell Tumor of Ovary|Granulosa Cell Tumor of the Ovary|Ovarian Granulosa Cell Neoplasm
C6262	Visual_Pathway_Neoplasm	Intracranial_Neoplasm	Visual Pathway Neoplasm|Neoplasm of Optic Tract|Neoplasm of Visual Pathway|Neoplasm of the Optic Tract|Neoplasm of the Visual Pathway|Optic Tract Neoplasm|Optic Tract Tumor|Tumor of Optic Tract|Tumor of Visual Pathway|Tumor of the Optic Tract|Tumor of the Visual Pathway|Visual Pathway Neoplasms|Visual Pathway Tumor
C6263	Malignant_Ovarian_Luteinized_Thecoma	Luteinized_Thecoma|Malignant_Thecoma	Malignant Ovarian Luteinized Thecoma|Malignant Luteinized Thecal Cell Neoplasm of Ovary|Malignant Luteinized Thecal Cell Neoplasm of the Ovary|Malignant Luteinized Thecal Cell Tumor of Ovary|Malignant Luteinized Thecal Cell Tumor of the Ovary|Malignant Luteinized Thecoma of Ovary|Malignant Luteinized Thecoma of the Ovary|Malignant Ovarian Luteinized Thecal Cell Neoplasm|Malignant Ovarian Luteinized Thecal Cell Tumor
C6264	Benign_Ovarian_Luteinized_Thecoma	Benign_Ovarian_Thecoma|Luteinized_Thecoma	Benign Ovarian Luteinized Thecoma|Benign Luteinized Ovarian Thecoma|Benign Luteinized Thecal Cell Neoplasm of Ovary|Benign Luteinized Thecal Cell Neoplasm of the Ovary|Benign Luteinized Thecal Cell Tumor of Ovary|Benign Luteinized Thecal Cell Tumor of the Ovary|Benign Luteinized Thecoma of Ovary|Benign Luteinized Thecoma of the Ovary|Benign Ovarian Luteinized Thecal Cell Neoplasm|Benign Ovarian Luteinized Thecal Cell Tumor
C6265	Fallopian_Tube_Adenocarcinoma	Adenocarcinoma|Fallopian_Tube_Carcinoma	Fallopian Tube Adenocarcinoma|Adenocarcinoma of Fallopian Tube|Adenocarcinoma of the Fallopian Tube
C6266	Pineal_Gland_Glial_Cyst	Pineal_Gland_Cyst	Pineal Gland Glial Cyst|Benign Glial Cyst of Pineal Gland|Benign Glial Cyst of the Pineal Gland|Benign Pineal Glial Cyst|Glial Cyst of Pineal Gland|Glial Cyst of the Pineal Gland|Pineal Glial Cyst
C6267	Fallopian_Tube_Papillary_Adenocarcinoma	Fallopian_Tube_Serous_Adenocarcinoma|Papillary_Adenocarcinoma	Fallopian Tube Papillary Adenocarcinoma|Papillary Adenocarcinoma of Fallopian Tube|Papillary Adenocarcinoma of the Fallopian Tube
C6268	Childhood_Cerebral_Ependymoma	Childhood_Supratentorial_Ependymoma	Childhood Cerebral Ependymoma|Pediatric Cerebral Ependymoma
C6269	Stage_IA_Fallopian_Tube_Cancer	Stage_I_Fallopian_Tube_Cancer	Stage IA Fallopian Tube Cancer|AJCC Stage IA Fallopian Tube Cancer|FIGO Stage IA Carcinoma of Fallopian Tube|FIGO Stage IA Carcinoma of the Fallopian Tube|FIGO Stage IA Fallopian Tube Carcinoma|Fallopian Tube Cancer Stage IA
C6270	Stage_IB_Fallopian_Tube_Cancer	Stage_I_Fallopian_Tube_Cancer	Stage IB Fallopian Tube Cancer|AJCC Stage IB Fallopian Tube Cancer|FIGO Stage IB Carcinoma of Fallopian Tube|FIGO Stage IB Carcinoma of the Fallopian Tube|FIGO Stage IB Fallopian Tube Carcinoma|Fallopian Tube Cancer Stage IB
C6271	Stage_IC_Fallopian_Tube_Cancer	Stage_I_Fallopian_Tube_Cancer	Stage IC Fallopian Tube Cancer|AJCC Stage IC Fallopian Tube Cancer|FIGO Stage IC Carcinoma of Fallopian Tube|FIGO Stage IC Carcinoma of the Fallopian Tube|FIGO Stage IC Fallopian Tube Carcinoma|Fallopian Tube Cancer Stage IC
C6272	Stage_IIA_Fallopian_Tube_Cancer	Stage_II_Fallopian_Tube_Cancer	Stage IIA Fallopian Tube Cancer|AJCC Stage IIA Fallopian Tube Cancer|FIGO Stage IIA Carcinoma of Fallopian Tube|FIGO Stage IIA Carcinoma of the Fallopian Tube|FIGO Stage IIA Fallopian Tube Carcinoma|Fallopian Tube Cancer Stage IIA
C6273	Stage_IIIA_Fallopian_Tube_Cancer	Stage_III_Fallopian_Tube_Cancer	Stage IIIA Fallopian Tube Cancer|AJCC Stage IIIA Fallopian Tube Cancer|FIGO Stage IIIA Carcinoma of Fallopian Tube|FIGO Stage IIIA Carcinoma of the Fallopian Tube|FIGO Stage IIIA Fallopian Tube Carcinoma|Fallopian Tube Cancer Stage IIIA
C6274	Stage_IIIB_Fallopian_Tube_Cancer	Stage_III_Fallopian_Tube_Cancer	Stage IIIB Fallopian Tube Cancer|AJCC Stage IIIB Fallopian Tube Cancer|FIGO Stage IIIB Carcinoma of Fallopian Tube|FIGO Stage IIIB Carcinoma of the Fallopian Tube|FIGO Stage IIIB Fallopian Tube Carcinoma|Fallopian Tube Cancer Stage IIIB
C6275	Stage_IIIC_Fallopian_Tube_Cancer	Stage_III_Fallopian_Tube_Cancer	Stage IIIC Fallopian Tube Cancer|AJCC Stage IIIC Fallopian Tube Cancer|FIGO Stage IIIC Carcinoma of Fallopian Tube|FIGO Stage IIIC Carcinoma of the Fallopian Tube|FIGO Stage IIIC Fallopian Tube Carcinoma|Fallopian Tube Cancer Stage IIIC
C6276	Stage_IIC_Fallopian_Tube_Cancer	Stage_II_Fallopian_Tube_Cancer	Stage IIC Fallopian Tube Cancer|AJCC Stage IIC Fallopian Tube Cancer|FIGO Stage IIC Carcinoma of Fallopian Tube|FIGO Stage IIC Carcinoma of the Fallopian Tube|FIGO Stage IIC Fallopian Tube Carcinoma|Fallopian Tube Cancer Stage IIC
C6277	Stage_IIB_Fallopian_Tube_Cancer	Stage_II_Fallopian_Tube_Cancer	Stage IIB Fallopian Tube Cancer|AJCC Stage IIB Fallopian Tube Cancer|FIGO Stage IIB Carcinoma of Fallopian Tube|FIGO Stage IIB Carcinoma of the Fallopian Tube|FIGO Stage IIB Fallopian Tube Carcinoma|Fallopian Tube Cancer Stage IIB
C6278	Fallopian_Tube_Gestational_Choriocarcinoma	Fallopian_Tube_Carcinoma|Gestational_Choriocarcinoma	Fallopian Tube Gestational Choriocarcinoma|Gestational Choriocarcinoma of Fallopian Tube|Gestational Choriocarcinoma of the Fallopian Tube
C6279	Fallopian_Tube_Endometrioid_Adenocarcinoma	Endometrioid_Carcinoma|Fallopian_Tube_Adenocarcinoma|Fallopian_Tube_Endometrioid_Tumor	Fallopian Tube Endometrioid Adenocarcinoma|Endometrioid Adenocarcinoma of Fallopian Tube|Endometrioid Adenocarcinoma of the Fallopian Tube|Endometrioid Carcinoma of Fallopian Tube|Endometrioid Carcinoma of the Fallopian Tube|Fallopian Tube Endometrioid Carcinoma
C6280	Fallopian_Tube_Clear_Cell_Adenocarcinoma	Clear_Cell_Adenocarcinoma|Fallopian_Tube_Adenocarcinoma	Fallopian Tube Clear Cell Adenocarcinoma|Clear Cell Adenocarcinoma of Fallopian Tube|Clear Cell Adenocarcinoma of the Fallopian Tube|Clear Cell Carcinoma of Fallopian Tube|Clear Cell Carcinoma of the Fallopian Tube|Fallopian Tube Clear Cell Carcinoma	A rare adenocarcinoma of the fallopian tube composed of malignant glandular epithelium containing clear cells.
C6281	Undifferentiated_Fallopian_Tube_Carcinoma	Fallopian_Tube_Carcinoma|Undifferentiated_Carcinoma	Undifferentiated Fallopian Tube Carcinoma|Undifferentiated Carcinoma of Fallopian Tube|Undifferentiated Carcinoma of the Fallopian Tube
C6282	Fallopian_Tube_Squamous_Cell_Carcinoma	Fallopian_Tube_Carcinoma|Squamous_Cell_Carcinoma	Fallopian Tube Squamous Cell Carcinoma|Squamous Cell Carcinoma of Fallopian Tube|Squamous Cell Carcinoma of the Fallopian Tube
C6283	Childhood_Neoplasm	Neoplasm_by_Special_Category	Childhood Neoplasm|Childhood Tumor|Childhood Tumors|Pediatric Neoplasm|Pediatric Tumor|Pediatric Tumors	Tumors commonly occurring before age 18.
C6284	Brain_Germinoma	Intracranial_Germinoma|Malignant_Brain_Neoplasm	Brain Germinoma|Germinoma of Brain|Germinoma of the Brain	A germ cell tumor characterized by large round eosinophilic cells and focal granulomas. These tumors are found in the ovary, testes (especially undescended) anterior mediastinum and pineal gland. Placental alkaline phosphatase is a known marker of the presence of this tumor. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1766)
C6285	Adult_Central_Nervous_System_Germ_Cell_Neoplasm	Adult_Central_Nervous_System_Neoplasm|Central_Nervous_System_Germ_Cell_Neoplasm	Adult Central Nervous System Germ Cell Tumor|Adult CNS Germ Cell Neoplasm|Adult CNS Germ Cell Tumor|Adult Central Nervous System Germ Cell Neoplasm|Germ Cell Neoplasm of Adult CNS|Germ Cell Neoplasm of Adult Central Nervous System|Germ Cell Neoplasm of the Adult CNS|Germ Cell Neoplasm of the Adult Central Nervous System|Germ Cell Tumor of Adult CNS|Germ Cell Tumor of Adult Central Nervous System|Germ Cell Tumor of the Adult CNS|Germ Cell Tumor of the Adult Central Nervous System
C6286	Childhood_Cerebellar_Astrocytoma	Cerebellar_Astrocytoma|Childhood_Astrocytic_Tumor|Childhood_Cerebellar_Neoplasm	Childhood Cerebellar Astrocytoma|Childhood Astrocytic Neoplasm of Cerebellum|Childhood Astrocytic Neoplasm of the Cerebellum|Childhood Astrocytic Tumor of Cerebellum|Childhood Astrocytic Tumor of the Cerebellum|Childhood Astrocytoma of Cerebellum|Childhood Astrocytoma of the Cerebellum|Childhood Cerebellar Astrocytic Neoplasm|Childhood Cerebellar Astrocytic Tumor|Pediatric Astrocytic Neoplasm of Cerebellum|Pediatric Astrocytic Neoplasm of the Cerebellum|Pediatric Astrocytic Tumor of Cerebellum|Pediatric Astrocytic Tumor of the Cerebellum|Pediatric Astrocytoma of Cerebellum|Pediatric Astrocytoma of the Cerebellum|Pediatric Cerebellar Astrocytic Neoplasm|Pediatric Cerebellar Astrocytic Tumor|Pediatric Cerebellar Astrocytoma	Benign and malignant astrocytomas that arise from astrocytes in the cerebellum.  More than 80% of childhood cerebellar astrocytomas are pilocytic astrocytomas which have a favorable prognosis. The remainder are composed of diffuse or fibrillary subtypes with malignant astrocytomas occuring only rarely in the cerebellum during childhood.
C6287	Uterine_Corpus_Endometrioid_Adenocarcinoma	Endometrioid_Carcinoma|Type_I_Endometrial_Adenocarcinoma	Endometrial Endometrioid Adenocarcinoma|Endometrioid Adenocarcinoma of Endometrium|Endometrioid Adenocarcinoma of the Endometrium|Endometrioid Carcinoma of Endometrium|Endometrioid Carcinoma of the Endometrium|Uterine Corpus Endometrioid Adenocarcinoma|Uterine Corpus Endometrioid Carcinoma	A primary endometrial adenocarcinoma composed of neoplastic cells that form complex glandular patterns associated with budding and branching of the neoplastic glands.  The neoplastic glands resemble those of the normal endometrium and may or may not be associated with sheet-like proliferation of malignant cells.  Endometrioid adenocarcinoma is the most commonly seen morphologic variant of endometrial adenocarcinoma. -- 2004
C6290	Endometrial_Adenosquamous_Carcinoma	Adenosquamous_Carcinoma|Endometrial_Carcinoma	Endometrial Adenosquamous Carcinoma|Adenosquamous Carcinoma of Endometrium|Adenosquamous Carcinoma of the Endometrium	An endometrial carcinoma characterized by the presence of both neoplastic glandular and squamous epithelial cells. -- 2004
C6291	Stage_IA_Ovarian_Germ_Cell_Tumor	Stage_I_Ovarian_Germ_Cell_Tumor	Stage IA Ovarian Germ Cell Tumor|FIGO Stage IA Malignant Germ Cell Neoplasm of Ovary|FIGO Stage IA Malignant Germ Cell Neoplasm of the Ovary|FIGO Stage IA Malignant Germ Cell Tumor of Ovary|FIGO Stage IA Malignant Germ Cell Tumor of the Ovary|FIGO Stage IA Malignant Ovarian Germ Cell Neoplasm|FIGO Stage IA Malignant Ovarian Germ Cell Tumor
C6292	Stage_IB_Ovarian_Germ_Cell_Tumor	Stage_I_Ovarian_Germ_Cell_Tumor	Stage IB Ovarian Germ Cell Tumor|FIGO Stage IB Malignant Germ Cell Neoplasm of Ovary|FIGO Stage IB Malignant Germ Cell Neoplasm of the Ovary|FIGO Stage IB Malignant Germ Cell Tumor of Ovary|FIGO Stage IB Malignant Germ Cell Tumor of the Ovary|FIGO Stage IB Malignant Ovarian Germ Cell Neoplasm|FIGO Stage IB Malignant Ovarian Germ Cell Tumor
C6293	Stage_IC_Ovarian_Germ_Cell_Tumor	Stage_I_Ovarian_Germ_Cell_Tumor	Stage IC Ovarian Germ Cell Tumor|FIGO Stage IC Malignant Germ Cell Neoplasm of Ovary|FIGO Stage IC Malignant Germ Cell Neoplasm of the Ovary|FIGO Stage IC Malignant Germ Cell Tumor of Ovary|FIGO Stage IC Malignant Germ Cell Tumor of the Ovary|FIGO Stage IC Malignant Ovarian Germ Cell Neoplasm|FIGO Stage IC Malignant Ovarian Germ Cell Tumor
C6294	Stage_IIC_Ovarian_Germ_Cell_Tumor	Stage_II_Ovarian_Germ_Cell_Tumor	Stage IIC Ovarian Germ Cell Tumor|FIGO Stage IIC Malignant Germ Cell Neoplasm of Ovary|FIGO Stage IIC Malignant Germ Cell Neoplasm of the Ovary|FIGO Stage IIC Malignant Germ Cell Tumor of Ovary|FIGO Stage IIC Malignant Germ Cell Tumor of the Ovary|FIGO Stage IIC Malignant Ovarian Germ Cell Neoplasm|FIGO Stage IIC Malignant Ovarian Germ Cell Tumor
C6295	Stage_IIB_Ovarian_Germ_Cell_Tumor	Stage_II_Ovarian_Germ_Cell_Tumor	Stage IIB Ovarian Germ Cell Tumor|FIGO Stage IIB Malignant Germ Cell Neoplasm of Ovary|FIGO Stage IIB Malignant Germ Cell Neoplasm of the Ovary|FIGO Stage IIB Malignant Germ Cell Tumor of Ovary|FIGO Stage IIB Malignant Germ Cell Tumor of the Ovary|FIGO Stage IIB Malignant Ovarian Germ Cell Neoplasm|FIGO Stage IIB Malignant Ovarian Germ Cell Tumor
C6296	Stage_IIA_Ovarian_Germ_Cell_Tumor	Stage_II_Ovarian_Germ_Cell_Tumor	Stage IIA Ovarian Germ Cell Tumor|FIGO Stage IIA Malignant Germ Cell Neoplasm of Ovary|FIGO Stage IIA Malignant Germ Cell Neoplasm of the Ovary|FIGO Stage IIA Malignant Germ Cell Tumor of Ovary|FIGO Stage IIA Malignant Germ Cell Tumor of the Ovary|FIGO Stage IIA Malignant Ovarian Germ Cell Neoplasm|FIGO Stage IIA Malignant Ovarian Germ Cell Tumor
C6297	Stage_IIIA_Ovarian_Germ_Cell_Tumor	Stage_III_Ovarian_Germ_Cell_Tumor	Stage IIIA Ovarian Germ Cell Tumor|FIGO Stage IIIA Malignant Germ Cell Neoplasm of Ovary|FIGO Stage IIIA Malignant Germ Cell Neoplasm of the Ovary|FIGO Stage IIIA Malignant Germ Cell Tumor of Ovary|FIGO Stage IIIA Malignant Germ Cell Tumor of the Ovary|FIGO Stage IIIA Malignant Ovarian Germ Cell Neoplasm|FIGO Stage IIIA Malignant Ovarian Germ Cell Tumor
C6298	Stage_IIIB_Ovarian_Germ_Cell_Tumor	Stage_III_Ovarian_Germ_Cell_Tumor	Stage IIIB Ovarian Germ Cell Tumor|FIGO Stage IIIB Malignant Germ Cell Neoplasm of Ovary|FIGO Stage IIIB Malignant Germ Cell Neoplasm of the Ovary|FIGO Stage IIIB Malignant Germ Cell Tumor of Ovary|FIGO Stage IIIB Malignant Germ Cell Tumor of the Ovary|FIGO Stage IIIB Malignant Ovarian Germ Cell Neoplasm|FIGO Stage IIIB Malignant Ovarian Germ Cell Tumor
C6299	Stage_IIIC_Ovarian_Germ_Cell_Tumor	Stage_III_Ovarian_Germ_Cell_Tumor	Stage IIIC Ovarian Germ Cell Tumor|FIGO Stage IIIC Malignant Germ Cell Neoplasm of Ovary|FIGO Stage IIIC Malignant Germ Cell Neoplasm of the Ovary|FIGO Stage IIIC Malignant Germ Cell Tumor of Ovary|FIGO Stage IIIC Malignant Germ Cell Tumor of the Ovary|FIGO Stage IIIC Malignant Ovarian Germ Cell Neoplasm|FIGO Stage IIIC Malignant Ovarian Germ Cell Tumor
C6300	Uterine_Corpus_Neoplasm	Uterine_Neoplasm	Uterine Corpus Neoplasm|Corpus Uteri Neoplasm|Corpus Uteri Tumor|Neoplasm of Body of Uterus|Neoplasm of Corpus Uteri|Neoplasm of Uterine Body|Neoplasm of Uterine Corpus|Neoplasm of the Body of Uterus|Neoplasm of the Corpus Uteri|Neoplasm of the Uterine Body|Neoplasm of the Uterine Corpus|Tumor of Corpus Uteri|Tumor of Uterine Body|Tumor of Uterine Corpus|Tumor of the Corpus Uteri|Tumor of the Uterine Body|Tumor of the Uterine Corpus|Uterine Body Neoplasm|Uterine Body Tumor|Uterine Corpus Tumor
C6301	Stage_IA_Endometrial_Cancer	Stage_I_Endometrial_Cancer	Stage IA Endometrial Cancer|Stage IA Endometrial Carcinoma
C6302	Stage_IB_Endometrial_Cancer	Stage_I_Endometrial_Cancer	Stage IB Endometrial Cancer|Stage IB Endometrial Carcinoma
C6303	Stage_IC_Endometrial_Cancer	Stage_I_Endometrial_Cancer	Stage IC Endometrial Cancer|Stage IC Endometrial Carcinoma
C6304	Stage_IIA_Endometrial_Cancer	Stage_II_Endometrial_Cancer	Stage IIA Endometrial Cancer|Stage IIA Endometrial Carcinoma
C6305	Stage_IIB_Endometrial_Cancer	Stage_II_Endometrial_Cancer	Stage IIB Endometrial Cancer|Stage IIB Endometrial Carcinoma
C6306	Stage_IIIA_Endometrial_Cancer	Stage_III_Endometrial_Cancer	Stage IIIA Endometrial Cancer|Stage IIIA Endometrial Carcinoma
C6307	Stage_IIIB_Endometrial_Cancer	Stage_III_Endometrial_Cancer	Stage IIIB Endometrial Cancer|Stage IIIB Endometrial Carcinoma
C6308	Stage_IIIC_Endometrial_Cancer	Stage_III_Endometrial_Cancer	Stage IIIC Endometrial Cancer|Stage IIIC Endometrial Carcinoma
C6309	Stage_IVA_Endometrial_Cancer	Stage_IV_Endometrial_Cancer	Stage IVA Endometrial Cancer|Stage IVA Endometrial Carcinoma
C6310	Stage_IVB_Endometrial_Cancer	Stage_IV_Endometrial_Cancer	Stage IVB Endometrial Cancer|Stage IVB Endometrial Carcinoma
C6311	Malignant_Uterine_Corpus_Mixed_Neoplasm	Malignant_Mixed_Neoplasm|Malignant_Uterine_Corpus_Neoplasm|Uterine_Corpus_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Malignant Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm|Malignant Body of Uterus Mixed Neoplasm|Malignant Body of Uterus Mixed Tumor|Malignant Corpus Uteri Mixed Neoplasm|Malignant Corpus Uteri Mixed Tumor|Malignant Mixed Neoplasm of Body of Uterus|Malignant Mixed Neoplasm of Corpus Uteri|Malignant Mixed Neoplasm of Uterine Body|Malignant Mixed Neoplasm of Uterine Corpus|Malignant Mixed Neoplasm of the Body of Uterus|Malignant Mixed Neoplasm of the Corpus Uteri|Malignant Mixed Neoplasm of the Uterine Body|Malignant Mixed Neoplasm of the Uterine Corpus|Malignant Mixed Tumor of Body of Uterus|Malignant Mixed Tumor of Corpus Uteri|Malignant Mixed Tumor of Uterine Body|Malignant Mixed Tumor of Uterine Corpus|Malignant Mixed Tumor of the Body of Uterus|Malignant Mixed Tumor of the Corpus Uteri|Malignant Mixed Tumor of the Uterine Body|Malignant Mixed Tumor of the Uterine Corpus|Malignant Uterine Body Mixed Neoplasm|Malignant Uterine Body Mixed Tumor|Malignant Uterine Corpus Mixed Tumor
C6313	Stage_IA_Cervical_Cancer	Stage_I_Cervical_Cancer	Stage IA Cervical Cancer|AJCC Stage IA Cervical Cancer|Cervical Cancer Stage IA|FIGO Stage IA Carcinoma of Cervix|FIGO Stage IA Carcinoma of Cervix Uteri|FIGO Stage IA Carcinoma of Uterine Cervix|FIGO Stage IA Carcinoma of the Cervix|FIGO Stage IA Carcinoma of the Cervix Uteri|FIGO Stage IA Carcinoma of the Uterine Cervix|FIGO Stage IA Cervical Carcinoma|FIGO Stage IA Cervix Carcinoma|FIGO Stage IA Cervix Uteri Carcinoma|FIGO Stage IA Uterine Cervix Carcinoma
C6314	Stage_IA1_Cervical_Cancer	Stage_IA_Cervical_Cancer	Stage IA1 Cervical Cancer|AJCC Stage IA1Cervical Cancer|Cervical Cancer Stage IA1|FIGO Stage IA1 Carcinoma of Cervix|FIGO Stage IA1 Carcinoma of Cervix Uteri|FIGO Stage IA1 Carcinoma of Uterine Cervix|FIGO Stage IA1 Carcinoma of the Cervix|FIGO Stage IA1 Carcinoma of the Cervix Uteri|FIGO Stage IA1 Carcinoma of the Uterine Cervix|FIGO Stage IA1 Cervical Carcinoma|FIGO Stage IA1 Cervix Carcinoma|FIGO Stage IA1 Cervix Uteri Carcinoma|FIGO Stage IA1 Uterine Cervix Carcinoma
C6315	Stage_IA2_Cervical_Cancer	Stage_IA_Cervical_Cancer	Stage IA2 Cervical Cancer|AJCC Stage IA2 Cervical Cancer|Cervical Cancer Stage IA2|FIGO Stage IA2 Carcinoma of Cervix|FIGO Stage IA2 Carcinoma of Cervix Uteri|FIGO Stage IA2 Carcinoma of Uterine Cervix|FIGO Stage IA2 Carcinoma of the Cervix|FIGO Stage IA2 Carcinoma of the Cervix Uteri|FIGO Stage IA2 Carcinoma of the Uterine Cervix|FIGO Stage IA2 Cervical Carcinoma|FIGO Stage IA2 Cervix Carcinoma|FIGO Stage IA2 Cervix Uteri Carcinoma|FIGO Stage IA2 Uterine Cervix Carcinoma
C6316	Stage_IB_Cervical_Cancer	Stage_I_Cervical_Cancer	Stage IB Cervical Cancer|AJCC Stage IB Cervical Cancer|Cervical Cancer Stage IB|FIGO Stage IB Carcinoma of Cervix|FIGO Stage IB Carcinoma of Cervix Uteri|FIGO Stage IB Carcinoma of Uterine Cervix|FIGO Stage IB Carcinoma of the Cervix|FIGO Stage IB Carcinoma of the Cervix Uteri|FIGO Stage IB Carcinoma of the Uterine Cervix|FIGO Stage IB Cervical Carcinoma|FIGO Stage IB Cervix Carcinoma|FIGO Stage IB Cervix Uteri Carcinoma|FIGO Stage IB Uterine Cervix Carcinoma
C6317	Stage_IB1_Cervical_Cancer	Stage_IB_Cervical_Cancer	Stage IB1 Cervical Cancer|AJCC Stage IB1 Cervical Cancer|Cervical Cancer Stage IB1|FIGO Stage IB1 Carcinoma of Cervix|FIGO Stage IB1 Carcinoma of Cervix Uteri|FIGO Stage IB1 Carcinoma of Uterine Cervix|FIGO Stage IB1 Carcinoma of the Cervix|FIGO Stage IB1 Carcinoma of the Cervix Uteri|FIGO Stage IB1 Carcinoma of the Uterine Cervix|FIGO Stage IB1 Cervical Carcinoma|FIGO Stage IB1 Cervix Carcinoma|FIGO Stage IB1 Cervix Uteri Carcinoma|FIGO Stage IB1 Uterine Cervix Carcinoma
C6318	Stage_IB2_Cervical_Cancer	Stage_IB_Cervical_Cancer	Stage IB2 Cervical Cancer|AJCC Stage IB2 Cervical Cancer|Cervical Cancer Stage IB2|FIGO Stage IB2 Carcinoma of Cervix|FIGO Stage IB2 Carcinoma of Cervix Uteri|FIGO Stage IB2 Carcinoma of Uterine Cervix|FIGO Stage IB2 Carcinoma of the Cervix|FIGO Stage IB2 Carcinoma of the Cervix Uteri|FIGO Stage IB2 Carcinoma of the Uterine Cervix|FIGO Stage IB2 Cervical Carcinoma|FIGO Stage IB2 Cervix Carcinoma|FIGO Stage IB2 Cervix Uteri Carcinoma|FIGO Stage IB2 Uterine Cervix Carcinoma
C6319	Stage_IIA_Cervical_Cancer	Stage_II_Cervical_Cancer	Stage IIA Cervical Cancer|AJCC Stage IIA Cervical Cancer|Cervical Cancer Stage IIA|FIGO Stage IIA Carcinoma of Cervix|FIGO Stage IIA Carcinoma of Cervix Uteri|FIGO Stage IIA Carcinoma of Uterine Cervix|FIGO Stage IIA Carcinoma of the Cervix|FIGO Stage IIA Carcinoma of the Cervix Uteri|FIGO Stage IIA Carcinoma of the Uterine Cervix|FIGO Stage IIA Cervical Carcinoma|FIGO Stage IIA Cervix Carcinoma|FIGO Stage IIA Cervix Uteri Carcinoma|FIGO Stage IIA Uterine Cervix Carcinoma
C6320	Stage_IIB_Cervical_Cancer	Stage_II_Cervical_Cancer	Stage IIB Cervical Cancer|AJCC Stage IIB Cervical Cancer|Cervical Cancer Stage II|FIGO Stage IIB Carcinoma of Cervix|FIGO Stage IIB Carcinoma of Cervix Uteri|FIGO Stage IIB Carcinoma of Uterine Cervix|FIGO Stage IIB Carcinoma of the Cervix|FIGO Stage IIB Carcinoma of the Cervix Uteri|FIGO Stage IIB Carcinoma of the Uterine Cervix|FIGO Stage IIB Cervical Carcinoma|FIGO Stage IIB Cervix Carcinoma|FIGO Stage IIB Cervix Uteri Carcinoma|FIGO Stage IIB Uterine Cervix Carcinoma
C6321	Stage_IIIB_Cervical_Cancer	Stage_III_Cervical_Cancer	Stage IIIB Cervical Cancer|AJCC Stage IIIB Cervical Cancer|Cervical Cancer Stage IIIB|FIGO Stage IIIB Carcinoma of Cervix|FIGO Stage IIIB Carcinoma of Cervix Uteri|FIGO Stage IIIB Carcinoma of Uterine Cervix|FIGO Stage IIIB Carcinoma of the Cervix|FIGO Stage IIIB Carcinoma of the Cervix Uteri|FIGO Stage IIIB Carcinoma of the Uterine Cervix|FIGO Stage IIIB Cervical Carcinoma|FIGO Stage IIIB Cervix Carcinoma|FIGO Stage IIIB Cervix Uteri Carcinoma|FIGO Stage IIIB Uterine Cervix Carcinoma
C6322	Stage_IIIA_Cervical_Cancer	Stage_III_Cervical_Cancer	Stage IIIA Cervical Cancer|AJCC Stage IIIA Cervical Cancer|Cervical Cancer Stage IIIA|FIGO Stage IIIA Carcinoma of Cervix|FIGO Stage IIIA Carcinoma of Cervix Uteri|FIGO Stage IIIA Carcinoma of Uterine Cervix|FIGO Stage IIIA Carcinoma of the Cervix|FIGO Stage IIIA Carcinoma of the Cervix Uteri|FIGO Stage IIIA Carcinoma of the Uterine Cervix|FIGO Stage IIIA Cervical Carcinoma|FIGO Stage IIIA Cervix Carcinoma|FIGO Stage IIIA Cervix Uteri Carcinoma|FIGO Stage IIIA Uterine Cervix Carcinoma
C6323	Stage_IVA_Cervical_Cancer	Stage_IV_Cervical_Cancer	Stage IVA Cervical Cancer|AJCC Stage IVA Cervical Cancer|Cervical Cancer Stage IVA|FIGO Stage IVA Carcinoma of Cervix|FIGO Stage IVA Carcinoma of Cervix Uteri|FIGO Stage IVA Carcinoma of Uterine Cervix|FIGO Stage IVA Carcinoma of the Cervix|FIGO Stage IVA Carcinoma of the Cervix Uteri|FIGO Stage IVA Carcinoma of the Uterine Cervix|FIGO Stage IVA Cervical Carcinoma|FIGO Stage IVA Cervix Carcinoma|FIGO Stage IVA Cervix Uteri Carcinoma|FIGO Stage IVA Uterine Cervix Carcinoma
C6324	Stage_IVB_Cervical_Cancer	Stage_IV_Cervical_Cancer	Stage IVB Cervical Cancer|AJCC Stage IVB Cervical Cancer|Cervical Cancer Stage IVB|FIGO Stage IVB Carcinoma of Cervix|FIGO Stage IVB Carcinoma of Cervix Uteri|FIGO Stage IVB Carcinoma of Uterine Cervix|FIGO Stage IVB Carcinoma of the Cervix|FIGO Stage IVB Carcinoma of the Cervix Uteri|FIGO Stage IVB Carcinoma of the Uterine Cervix|FIGO Stage IVB Cervical Carcinoma|FIGO Stage IVB Cervix Carcinoma|FIGO Stage IVB Cervix Uteri Carcinoma|FIGO Stage IVB Uterine Cervix Carcinoma
C6325	Vaginal_Verrucous_Carcinoma	Vaginal_Squamous_Cell_Carcinoma|Verrucous_Carcinoma	Vaginal Verrucous Carcinoma|Vagina Verrucous Carcinoma|Vagina Verrucous Squamous Cell Carcinoma|Vaginal Verrucous Squamous Cell Carcinoma|Verrucous Carcinoma of Vagina|Verrucous Carcinoma of the Vagina|Verrucous Squamous Cell Carcinoma of Vagina|Verrucous Squamous Cell Carcinoma of the Vagina
C6326	Vaginal_Leiomyosarcoma	Leiomyosarcoma|Vaginal_Sarcoma	Vaginal Leiomyosarcoma|Leiomyosarcoma of Vagina|Leiomyosarcoma of the Vagina|Vagina Leiomyosarcoma
C6327	Vaginal_Embryonal_Rhabdomyosarcoma	Retired_Concepts	Vaginal Embryonal Rhabdomyosarcoma|Embryonal Rhabdomyosarcoma of the Vagina|Vagina Embryonal Rhabdomyosarcoma
C6328	Stage_IA_Vulvar_Carcinoma	Stage_I_Vulvar_Cancer	Stage IA Vulvar Carcinoma|Stage IA Carcinoma of Vulva|Stage IA Carcinoma of the Vulva|Stage IA Vulva Carcinoma	Stage IA includes: Tia, N0, M0.  T1a: Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension, and with stromal invasion no greater than 1mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C6329	Stage_IB_Vulvar_Carcinoma	Stage_I_Vulvar_Cancer	Stage IB Vulvar Carcinoma|Stage IB Carcinoma of Vulva|Stage IB Carcinoma of the Vulva|Stage IB Vulva Carcinoma	Stage IB includes: T1b, N0, M0.  T1ab Tumor confined to the vulva or vulva and perineum, 2cm or less in greatest dimension, and with stromal invasion greater than 1mm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C6330	Stage_IVA_Vulvar_Cancer	Stage_IV_Vulvar_Cancer	Stage IVA Vulvar Cancer|Stage IVA Carcinoma of Vulva|Stage IVA Carcinoma of the Vulva|Stage IVA Vulva Cancer|Stage IVA Vulva Carcinoma|Stage IVA Vulval Cancer|Stage IVA Vulval Carcinoma|Stage IVA Vulvar Carcinoma	Stage IVA includes: IVA (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4, Any N, M0).  N2: Bilateral regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C6332	Metastasis_to_the_Vulva	Malignant_Vulvar_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Vulva|Metastasis to the Vulva|Metastatic Neoplasm to the Vulva|Vulvar Metastasis
C6333	Metastasis_to_the_Vagina	Malignant_Vaginal_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Vagina|Metastasis to Vagina|Metastasis to the Vagina|Metastatic Neoplasm to the Vagina|Secondary Tumor to Vagina|Secondary Tumor to the Vagina
C6334	Metastatic_Carcinoma_to_the_Uterine_Cervix	Metastasis_to_the_Cervix|Metastatic_Carcinoma	Metastatic Carcinoma to the Uterine Cervix|Metastatic Carcinoma to the Cervix|Metastatic Carcinoma to the Cervix Uteri|Secondary Carcinoma to the Cervix|Secondary Carcinoma to the Cervix Uteri|Secondary Carcinoma to the Uterine Cervix
C6335	Benign_Uterine_Corpus_Mixed_Neoplasm	Benign_Uterine_Corpus_Neoplasm|Uterine_Corpus_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Benign Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm|Benign Corpus Uteri Mixed Neoplasm|Benign Corpus Uteri Mixed Tumor|Benign Mixed Neoplasm of Body of Uterus|Benign Mixed Neoplasm of Corpus Uteri|Benign Mixed Neoplasm of Uterine Body|Benign Mixed Neoplasm of Uterine Corpus|Benign Mixed Neoplasm of the Body of Uterus|Benign Mixed Neoplasm of the Corpus Uteri|Benign Mixed Neoplasm of the Uterine Body|Benign Mixed Neoplasm of the Uterine Corpus|Benign Mixed Tumor of Body of Uterus|Benign Mixed Tumor of Corpus Uteri|Benign Mixed Tumor of Uterine Body|Benign Mixed Tumor of Uterine Corpus|Benign Mixed Tumor of the Body of Uterus|Benign Mixed Tumor of the Corpus Uteri|Benign Mixed Tumor of the Uterine Body|Benign Mixed Tumor of the Uterine Corpus|Benign Uterine Body Mixed Neoplasm|Benign Uterine Body Mixed Tumor|Benign Uterine Corpus Mixed Tumor
C6336	Uterine_Corpus_Mullerian_Adenosarcoma	Malignant_Uterine_Corpus_Mixed_Neoplasm|Mullerian_Adenosarcoma	Uterine Corpus Adenosarcoma|Adenosarcoma of Body of Uterus|Adenosarcoma of Uterine Body|Adenosarcoma of Uterine Corpus|Adenosarcoma of the Body of Uterus|Adenosarcoma of the Uterine Body|Adenosarcoma of the Uterine Corpus|Body of Uterus Adenosarcoma|Uterine Body Adenosarcoma|Uterine Corpus Mullerian Adenosarcoma
C6337	Uterine_Corpus_Adenofibroma	Adenofibroma|Benign_Uterine_Corpus_Mixed_Neoplasm	Uterine Corpus Adenofibroma|Adenofibroma of Body of Uterus|Adenofibroma of Corpus Uteri|Adenofibroma of Uterine Body|Adenofibroma of Uterine Corpus|Adenofibroma of the Body of Uterus|Adenofibroma of the Corpus Uteri|Adenofibroma of the Uterine Body|Adenofibroma of the Uterine Corpus|Corpus Uteri Adenofibroma|Uterine Body Adenofibroma
C6338	Uterine_Corpus_Adenomyoma	Adenomyoma|Benign_Uterine_Corpus_Mixed_Neoplasm	Uterine Corpus Adenomyoma|Adenomyoma of Body of Uterus|Adenomyoma of Corpus Uteri|Adenomyoma of Uterine Body|Adenomyoma of Uterine Corpus|Adenomyoma of the Body of Uterus|Adenomyoma of the Corpus Uteri|Adenomyoma of the Uterine Body|Adenomyoma of the Uterine Corpus|Corpus Uteri Adenomyoma|Uterine Body Adenomyoma
C6339	Uterine_Corpus_Sarcoma	Malignant_Uterine_Corpus_Neoplasm|Soft_Tissue_Sarcoma	Uterine Corpus Sarcoma|Body of Uterus Sarcoma|Corpus Uteri Sarcoma|Sarcoma of Body of Uterus|Sarcoma of Corpus Uteri|Sarcoma of Uterine Body|Sarcoma of Uterine Corpus|Sarcoma of Uterus|Sarcoma of the Body of Uterus|Sarcoma of the Corpus Uteri|Sarcoma of the Uterine Body|Sarcoma of the Uterine Corpus|Sarcoma of the Uterus|Uterine Body Sarcoma|Uterine Sarcoma|Uterus Sarcoma	A malignant mesenchymal tumor arising from the wall of the uterine corpus (uterine body).  The most representative examples are leiomyosarcoma and endometrial stromal sarcoma. -- 2004
C6340	Uterine_Corpus_Leiomyosarcoma	Leiomyosarcoma|Uterine_Corpus_Sarcoma|Uterine_Corpus_Smooth_Muscle_Neoplasm	Uterine Corpus Leiomyosarcoma|Body of Uterus Leiomyosarcoma|Corpus Uteri Leiomyosarcoma|Leiomyosarcoma of Body of Uterus|Leiomyosarcoma of Corpus Uteri|Leiomyosarcoma of Uterine Body|Leiomyosarcoma of Uterine Corpus|Leiomyosarcoma of Uterus|Leiomyosarcoma of the Body of Uterus|Leiomyosarcoma of the Corpus Uteri|Leiomyosarcoma of the Uterine Body|Leiomyosarcoma of the Uterine Corpus|Leiomyosarcoma of the Uterus|Uterine Body Leiomyosarcoma	A rare smooth muscle neoplasm which often presents with aberrant vaginal bleeding. By the time it becomes symptomatic, a mass can be detected in the pelvis. This tumor can metastasize directly or through hematogenous and/or lymphatic routes. It has a poor prognosis, especially if it has spread outside of the uterus at the time of discovery.
C6341	Testicular_Embryonal_Carcinoma	Embryonal_Carcinoma|Malignant_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Pure_Testicular_Germ_Cell_Tumor	Testicular Embryonal Carcinoma|Embryonal Carcinoma of Testis|Embryonal Carcinoma of the Testis	A germ cell neoplasm composed of primitive epithelial cells arranged in solid, papillary, and glandular configurations.  Most patients present with a testicular mass, which may be associated with pain.  More than half of the patients have metastatic disease at diagnosis.  The form of treatment following radical orchiectomy is stage dependent. -- 2003
C6342	Uterine_Cervix_Squamous_Papilloma	Benign_Cervical_Neoplasm|Cervical_Squamous_Neoplasm|Squamous_Cell_Papilloma	Cervical Squamous Papilloma|Cervix Squamous Papilloma|Cervix Uteri Squamous Papilloma|Squamous Papilloma of Cervix|Squamous Papilloma of Cervix Uteri|Squamous Papilloma of Uterine Cervix|Squamous Papilloma of the Cervix|Squamous Papilloma of the Cervix Uteri|Squamous Papilloma of the Uterine Cervix|Uterine Cervix Squamous Papilloma
C6343	Cervical_Endometrioid_Adenocarcinoma	Cervical_Adenocarcinoma|Endometrioid_Carcinoma	Cervical Endometrioid Adenocarcinoma|Cervical Endometrioid Carcinoma|Cervix Endometrioid Adenocarcinoma|Cervix Endometrioid Carcinoma|Cervix Uteri Endometrioid Adenocarcinoma|Cervix Uteri Endometrioid Carcinoma|Endometrioid Adenocarcinoma of Cervix|Endometrioid Adenocarcinoma of Cervix Uteri|Endometrioid Adenocarcinoma of Uterine Cervix|Endometrioid Adenocarcinoma of the Cervix|Endometrioid Adenocarcinoma of the Cervix Uteri|Endometrioid Adenocarcinoma of the Uterine Cervix|Endometrioid Carcinoma of Cervix|Endometrioid Carcinoma of Cervix Uteri|Endometrioid Carcinoma of Uterine Cervix|Endometrioid Carcinoma of the Cervix|Endometrioid Carcinoma of the Cervix Uteri|Endometrioid Carcinoma of the Uterine Cervix|Uterine Cervix Endometrioid Adenocarcinoma|Uterine Cervix Endometrioid Carcinoma
C6344	Cervical_Clear_Cell_Carcinoma	Cervical_Adenocarcinoma|Clear_Cell_Adenocarcinoma	Cervical Clear Cell Adenocarcinoma|Cervical Clear Cell Carcinoma|Cervix Clear Cell Adenocarcinoma|Cervix Clear Cell Carcinoma|Cervix Uteri Clear Cell Adenocarcinoma|Cervix Uteri Clear Cell Carcinoma|Clear Cell Adenocarcinoma of Cervix|Clear Cell Adenocarcinoma of Cervix Uteri|Clear Cell Adenocarcinoma of Uterine Cervix|Clear Cell Adenocarcinoma of the Cervix|Clear Cell Adenocarcinoma of the Cervix Uteri|Clear Cell Adenocarcinoma of the Uterine Cervix|Clear Cell Carcinoma of Cervix|Clear Cell Carcinoma of Cervix Uteri|Clear Cell Carcinoma of Uterine Cervix|Clear Cell Carcinoma of the Cervix|Clear Cell Carcinoma of the Cervix Uteri|Clear Cell Carcinoma of the Uterine Cervix|Uterine Cervix Clear Cell Adenocarcinoma|Uterine Cervix Clear Cell Carcinoma	A rare morphologic variant of cervical adenocarcinoma composed of clear and hobnail cells. It is associated with in utero exposure to diethylstilbestrol (DES).
C6345	Undifferentiated_Cervical_Carcinoma	Cervical_Carcinoma|Undifferentiated_Carcinoma	Cervical Undifferentiated Carcinoma|Undifferentiated Carcinoma of Cervix|Undifferentiated Carcinoma of Cervix Uteri|Undifferentiated Carcinoma of Uterine Cervix|Undifferentiated Carcinoma of the Cervix|Undifferentiated Carcinoma of the Cervix Uteri|Undifferentiated Carcinoma of the Uterine Cervix|Undifferentiated Cervix Carcinoma|Undifferentiated Cervix Uteri Carcinoma|Undifferentiated Uterine Cervix Carcinoma
C6346	Cervical_Adenoid_Cystic_Carcinoma	Adenoid_Cystic_Carcinoma|Cervical_Carcinoma	Cervical Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Cervix|Adenoid Cystic Carcinoma of Cervix Uteri|Adenoid Cystic Carcinoma of Uterine Cervix|Adenoid Cystic Carcinoma of the Cervix|Adenoid Cystic Carcinoma of the Cervix Uteri|Adenoid Cystic Carcinoma of the Uterine Cervix|Cervix Adenoid Cystic Carcinoma|Cervix Uteri Adenoid Cystic Carcinoma|Uterine Cervix Adenoid Cystic Carcinoma
C6347	Testicular_Mixed_Germ_Cell_Neoplasm	Malignant_Testicular_Germ_Cell_Tumor|Mixed_Germ_Cell_Neoplasm	Testicular Mixed Germ Cell Tumor|Mixed Germ Cell Neoplasm of Testis|Mixed Germ Cell Neoplasm of the Testis|Mixed Germ Cell Tumor of Testis|Mixed Germ Cell Tumor of the Testis|Testicular Germ Cell Tumor (Mixed)|Testicular Mixed Germ Cell Neoplasm
C6348	Testicular_Mixed_Choriocarcinoma_and_Embryonal_Carcinoma	Testicular_Mixed_Germ_Cell_Neoplasm	Testicular Mixed Choriocarcinoma and Embryonal Carcinoma|Mixed Choriocarcinoma and Embryonal Carcinoma of Testis|Mixed Choriocarcinoma and Embryonal Carcinoma of the Testis
C6349	Testicular_Mixed_Choriocarcinoma_and_Teratoma	Testicular_Mixed_Germ_Cell_Neoplasm	Testicular Mixed Choriocarcinoma and Teratoma|Mixed Choriocarcinoma and Teratoma of Testis|Mixed Choriocarcinoma and Teratoma of the Testis
C6350	Testicular_Mixed_Embryonal_Carcinoma_and_Seminoma	Testicular_Mixed_Germ_Cell_Neoplasm	Testicular Mixed Embryonal Carcinoma and Seminoma|Mixed Embryonal Carcinoma and Seminoma of Testis|Mixed Embryonal Carcinoma and Seminoma of the Testis
C6351	Testicular_Mixed_Embryonal_Carcinoma_and_Teratoma	Mixed_Embryonal_Carcinoma_and_Teratoma|Testicular_Mixed_Germ_Cell_Neoplasm	Testicular Mixed Embryonal Carcinoma and Teratoma|Mixed Embryonal Carcinoma and Teratoma of Testis|Mixed Embryonal Carcinoma and Teratoma of the Testis
C6352	Testicular_Mixed_Embryonal_Carcinoma_and_Teratoma_with_Seminoma	Testicular_Mixed_Germ_Cell_Neoplasm	Testicular Mixed Embryonal Carcinoma and Teratoma with Seminoma|Mixed Embryonal Carcinoma and Teratoma with Seminoma of Testis|Mixed Embryonal Carcinoma and Teratoma with Seminoma of the Testis
C6353	Immature_Testicular_Teratoma	Immature_Teratoma|Testicular_Teratoma	Immature Testicular Teratoma|Immature Teratoma of Testis|Immature Teratoma of the Testis|Malignant Teratoma of Testis|Malignant Teratoma of the Testis|Malignant Testicular Teratoma|Testicular Immature Teratoma|Testicular Malignant Teratoma
C6354	Classic_Seminoma	Retired_Concepts	Classic Seminoma|Typical Seminoma
C6355	Mature_Testicular_Teratoma	Mature_Teratoma|Testicular_Teratoma	Mature Testicular Teratoma|Mature Teratoma of Testis|Mature Teratoma of the Testis|Testicular Mature Teratoma
C6356	Testicular_Leydig_Cell_Tumor	Leydig_Cell_Tumor|Testicular_Sex_Cord-Stromal_Tumor	Testicular Leydig Cell Tumor|Leydig Cell Neoplasm of Testis|Leydig Cell Neoplasm of the Testis|Leydig Cell Tumor of Testis|Leydig Cell Tumor of the Testis|Testicular Leydig Cell Neoplasm
C6357	Testicular_Granulosa_Cell_Tumor	Granulosa_Cell_Tumor|Testicular_Sex_Cord-Stromal_Tumor	Testicular Granulosa Cell Tumor|Granulosa Cell Neoplasm of Testis|Granulosa Cell Neoplasm of the Testis|Granulosa Cell Tumor of Testis|Granulosa Cell Tumor of the Testis|Testicular Granulosa Cell Neoplasm
C6358	Testicular_Sex_Cord-Stromal_Tumor	Infrequent_Neoplasm|Sex_Cord-Stromal_Tumor|Testicular_Neoplasm	Testicular Sex Cord-Stromal Tumor|Sex Cord-Stromal Neoplasm of Testis|Sex Cord-Stromal Neoplasm of the Testis|Sex Cord-Stromal Tumor of Testis|Sex Cord-Stromal Tumor of the Testis|Testicular Sex Cord-Stromal Neoplasm
C6359	Testicular_Sarcoma	Malignant_Testicular_Neoplasm|Soft_Tissue_Sarcoma	Testicular Sarcoma|Sarcoma of Testis|Sarcoma of the Testis
C6360	Testicular_Carcinoid_Tumor	Carcinoid_Tumor|Malignant_Testicular_Neoplasm	Testicular Carcinoid Tumor|Carcinoid Neoplasm of Testis|Carcinoid Neoplasm of the Testis|Carcinoid Tumor of Testis|Carcinoid Tumor of the Testis|Testicular Carcinoid Neoplasm
C6361	Stage_IA_Testicular_Cancer	Stage_I_Testicular_Cancer	Stage IA Testicular Cancer|Stage IA Cancer of Testis|Stage IA Cancer of the Testis
C6362	Stage_IB_Testicular_Cancer	Stage_I_Testicular_Cancer	Stage IB Testicular Cancer|Stage IB Cancer of Testis|Stage IB Cancer of the Testis
C6363	Stage_IC_Testicular_Cancer	Stage_I_Testicular_Cancer	Stage IC Testicular Cancer|Stage IC Cancer of Testis|Stage IC Cancer of the Testis
C6364	Stage_IIA_Testicular_Cancer	Stage_II_Testicular_Cancer	Stage IIA Testicular Cancer|Stage IIA Cancer of Testis|Stage IIA Cancer of the Testis
C6365	Stage_IIB_Testicular_Cancer	Stage_II_Testicular_Cancer	Stage IIB Testicular Cancer|Stage IIB Cancer of Testis|Stage IIB Cancer of the Testis
C6366	Stage_IIC_Testicular_Cancer	Stage_II_Testicular_Cancer	Stage IIC Testicular Cancer|Stage IIC Cancer of Testis|Stage IIC Cancer of the Testis
C6367	Stage_IIIC_Testicular_Cancer	Stage_III_Testicular_Cancer	Stage IIIC Testicular Cancer|Stage IIIC Cancer of Testis|Stage IIIC Cancer of the Testis
C6368	Stage_IIIB_Testicular_Cancer	Stage_III_Testicular_Cancer	Stage IIIB Testicular Cancer|Stage IIIB Cancer of Testis|Stage IIIB Cancer of the Testis
C6369	Stage_IIIA_Testicular_Cancer	Stage_III_Testicular_Cancer	Stage IIIA Testicular Cancer|Stage IIIA Cancer of Testis|Stage IIIA Cancer of the Testis|Testicular Cancer Stage IIIA
C6370	Testicular_Epidermoid_Cyst	Testicular_Cyst	Testicular Epidermoid Cyst|Epidermoid Cyst of Testis|Epidermoid Cyst of the Testis|Squamous Cell Cyst of Testis|Squamous Cell Cyst of the Testis|Testicular Squamous Cell Cyst
C6371	Giant_Condyloma_Acuminatum	Condyloma_Acuminatum|Male_Reproductive_System_Precancerous_Condition|Penile_Neoplasm	Giant Condyloma Acuminatum|Buschke-Lowenstein Neoplasm of Penis|Buschke-Lowenstein Neoplasm of the Penis|Buschke-Lowenstein Tumor|Buschke-Lowenstein Tumor of Penis|Buschke-Lowenstein Tumor of the Penis|Giant Condyloma Acuminatum of Penis|Giant Condyloma Acuminatum of the Penis|Penile Buschke-Lowenstein Neoplasm|Penile Buschke-Lowenstein Tumor|Penile Giant Condyloma Acuminatum	Currently classified as a verrucous carcinoma, this is a large penile lesion with indolent clinical course, composed of well-differentiated squamous cells. -- 2003
C6372	Vaginal_Rhabdomyoma	Benign_Vaginal_Neoplasm|Genital_Rhabdomyoma|Vaginal_Soft_Tissue_Neoplasm	Vaginal Rhabdomyoma|Rhabdomyoma of Vagina|Rhabdomyoma of the Vagina
C6373	Vaginal_Leiomyoma	Benign_Vaginal_Neoplasm|Leiomyoma|Vaginal_Soft_Tissue_Neoplasm	Vaginal Leiomyoma|Leiomyoma of Vagina|Leiomyoma of the Vagina
C6374	Vaginal_Squamous_Papilloma	Benign_Vaginal_Neoplasm|Squamous_Cell_Papilloma|Vaginal_Squamous_Neoplasm	Vaginal Squamous Papilloma|Squamous Papilloma of Vagina|Squamous Papilloma of the Vagina
C6375	Vulvar_Seborrheic_Keratosis	Seborrheic_Keratosis|Vulvar_Squamous_Neoplasm	Vulvar Seborrheic Keratosis|Seborrheic Keratosis of Vulva|Seborrheic Keratosis of the Vulva
C6376	Vulvar_Squamous_Papilloma	Benign_Vulvar_Neoplasm|Vulvar_Squamous_Neoplasm	Vestibular Papilloma|Vulvar Squamous Papilloma
C6377	Penile_Kaposi_s_Sarcoma	Kaposi_s_Sarcoma|Penile_Sarcoma	Penile Kaposi's Sarcoma|Kaposi's Sarcoma of Penis|Kaposi's Sarcoma of the Penis
C6378	Testicular_Rhabdomyosarcoma	Rhabdomyosarcoma|Testicular_Sarcoma	Testicular Rhabdomyosarcoma|Rhabdomyosarcoma of Testis|Rhabdomyosarcoma of the Testis
C6379	Vaginal_Yolk_Sac_Tumor	Malignant_Vaginal_Neoplasm|Yolk_Sac_Tumor	Vaginal Yolk Sac Tumor|Vaginal Endodermal Sinus Neoplasm|Vaginal Endodermal Sinus Tumor|Vaginal Yolk Sac Neoplasm
C6380	Vulvar_Adenocarcinoma	Adenocarcinoma|Vulvar_Carcinoma|Vulvar_Glandular_Neoplasm	Vulvar Adenocarcinoma|Adenocarcinoma of Vulva|Adenocarcinoma of the Vulva
C6381	Vulvar_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma|Vulvar_Carcinoma	Vulvar Basal Cell Carcinoma|Basal Cell Carcinoma of Vulva|Basal Cell Carcinoma of the Vulva
C6382	Epididymal_Adenomatoid_Tumor	Adenomatoid_Tumor|Benign_Epididymal_Neoplasm	Epididymal Adenomatoid Tumor|Adenomatoid Neoplasm of Epididymis|Adenomatoid Neoplasm of the Epididymis|Adenomatoid Tumor of Epididymis|Adenomatoid Tumor of the Epididymis|Benign Epididymal Epithelial Mesothelioma
C6383	Vulvar_Verrucous_Carcinoma	Verrucous_Carcinoma|Vulvar_Squamous_Cell_Carcinoma	Vulvar Verrucous Carcinoma|Verrucous Carcinoma of Vulva|Verrucous Carcinoma of the Vulva
C6384	Paratesticular_Lipoma	Benign_Male_Reproductive_System_Neoplasm|Lipoma	Paratesticular Lipoma
C6385	Metastasis_to_the_Cervix	Malignant_Cervical_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Cervix|Metastasis to the Cervix|Metastasis to the Cervix Uteri|Metastasis to the Uterine Cervix|Metastatic Malignant Neoplasm to the Uterine Cervix|Metastatic Malignant Tumor to the Cervix|Metastatic Malignant Tumor to the Uterine Cervix
C6386	Scrotal_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma|Scrotal_Carcinoma	Scrotal Basal Cell Carcinoma|Basal Cell Carcinoma of Scrotum|Basal Cell Carcinoma of the Scrotum
C6387	Scrotal_Hemangioma	Benign_Scrotal_Neoplasm|Hemangioma_of_the_Skin	Scrotal Hemangioma|Angioma of Scrotum|Angioma of the Scrotum|Hemangioma of Scrotum|Hemangioma of the Scrotum|Scrotal Angioma
C6388	Scrotal_Epidermoid_Cyst	Epidermal_Inclusion_Cyst|Scrotal_Cyst	Scrotal Epidermoid Cyst|Epidermoid Cyst of Scrotum|Epidermoid Cyst of the Scrotum
C6389	Scrotal_Carcinoma	Malignant_Scrotal_Neoplasm|Skin_Carcinoma	Scrotal Carcinoma|Cancer of Scrotum|Cancer of the Scrotum|Carcinoma of Scrotum|Carcinoma of the Scrotum|Scrotal Cancer
C6390	Gestational_Trophoblastic_Tumor_by_FIGO_Stage	Gestational_Trophoblastic_Tumor	Gestational Trophoblastic Tumor by FIGO Stage
C6391	FIGO_Stage_I_Gestational_Trophoblastic_Tumor	Gestational_Trophoblastic_Tumor_by_FIGO_Stage	FIGO Stage I Gestational Trophoblastic Tumor|FIGO Stage I GTT|FIGO Stage I Gestational Trophoblastic Neoplasm
C6392	FIGO_Stage_IA_Gestational_Trophoblastic_Tumor	FIGO_Stage_I_Gestational_Trophoblastic_Tumor	FIGO Stage IA Gestational Trophoblastic Tumor|FIGO Stage IA GTT|FIGO Stage IA Gestational Trophoblastic Neoplasm
C6393	Invasive_Ductal_and_Invasive_Lobular_Breast_Carcinoma	Invasive_Ductal_and_Lobular_Carcinoma	Invasive Ductal and Invasive Lobular Breast Carcinoma|Infiltrating Ductal and Infiltrating Lobular Breast Carcinoma
C6394	FIGO_Stage_IB_Gestational_Trophoblastic_Tumor	FIGO_Stage_I_Gestational_Trophoblastic_Tumor	FIGO Stage IB Gestational Trophoblastic Tumor|FIGO Stage IB GTT|FIGO Stage IB Gestational Trophoblastic Neoplasm
C6395	FIGO_Stage_IC_Gestational_Trophoblastic_Tumor	FIGO_Stage_I_Gestational_Trophoblastic_Tumor	FIGO Stage IC Gestational Trophoblastic Tumor|FIGO Stage IC GTT|FIGO Stage IC Gestational Trophoblastic Neoplasm
C6396	FIGO_Stage_II_Gestational_Trophoblastic_Tumor	Gestational_Trophoblastic_Tumor_by_FIGO_Stage	FIGO Stage II Gestational Trophoblastic Tumor|FIGO Stage II GTT|FIGO Stage II Gestational Trophoblastic Neoplasm
C6397	FIGO_Stage_IIA_Gestational_Trophoblastic_Tumor	FIGO_Stage_II_Gestational_Trophoblastic_Tumor	FIGO Stage IIA Gestational Trophoblastic Tumor|FIGO Stage IIA GTT|FIGO Stage IIA Gestational Trophoblastic Neoplasm
C6398	FIGO_Stage_IIB_Gestational_Trophoblastic_Tumor	FIGO_Stage_II_Gestational_Trophoblastic_Tumor	FIGO Stage IIB Gestational Trophoblastic Tumor|FIGO Stage IIB GTT|FIGO Stage IIB Gestational Trophoblastic Neoplasm
C6399	FIGO_Stage_IIC_Gestational_Trophoblastic_Tumor	FIGO_Stage_II_Gestational_Trophoblastic_Tumor	FIGO Stage IIC Gestational Trophoblastic Tumor|FIGO Stage IIC GTT|FIGO Stage IIC Gestational Trophoblastic Neoplasm
C6400	FIGO_Stage_III_Gestational_Trophoblastic_Tumor	Gestational_Trophoblastic_Tumor_by_FIGO_Stage	FIGO Stage III Gestational Trophoblastic Tumor|FIGO Stage III GTT|FIGO Stage III Gestational Trophoblastic Neoplasm
C6401	FIGO_Stage_IIIA_Gestational_Trophoblastic_Tumor	FIGO_Stage_III_Gestational_Trophoblastic_Tumor	FIGO Stage IIIA Gestational Trophoblastic Tumor|FIGO Stage IIIA GTT|FIGO Stage IIIA Gestational Trophoblastic Neoplasm
C6402	FIGO_Stage_IIIB_Gestational_Trophoblastic_Tumor	FIGO_Stage_III_Gestational_Trophoblastic_Tumor	FIGO Stage IIIB Gestational Trophoblastic Tumor|FIGO Stage IIIB GTT|FIGO Stage IIIB Gestational Trophoblastic Neoplasm
C6403	FIGO_Stage_IIIC_Gestational_Trophoblastic_Tumor	FIGO_Stage_III_Gestational_Trophoblastic_Tumor	FIGO Stage IIIC Gestational Trophoblastic Tumor|FIGO Stage IIIC GTT|FIGO Stage IIIC Gestational Trophoblastic Neoplasm
C6404	FIGO_Stage_IV_Gestational_Trophoblastic_Tumor	Gestational_Trophoblastic_Tumor_by_FIGO_Stage	FIGO Stage IV Gestational Trophoblastic Tumor|FIGO Stage IV GTT|FIGO Stage IV Gestational Trophoblastic Neoplasm
C6405	FIGO_Stage_IVA_Gestational_Trophoblastic_Tumor	FIGO_Stage_IV_Gestational_Trophoblastic_Tumor	FIGO Stage IVA Gestational Trophoblastic Tumor|FIGO Stage IVA GTT|FIGO Stage IVA Gestational Trophoblastic Neoplasm
C6406	FIGO_Stage_IVB_Gestational_Trophoblastic_Tumor	FIGO_Stage_IV_Gestational_Trophoblastic_Tumor	FIGO Stage IVB Gestational Trophoblastic Tumor|FIGO Stage IVB GTT|FIGO Stage IVB Gestational Trophoblastic Neoplasm
C6407	FIGO_Stage_IVC_Gestational_Trophoblastic_Tumor	FIGO_Stage_IV_Gestational_Trophoblastic_Tumor	FIGO Stage IVC Gestational Trophoblastic Tumor|FIGO Stage IVC GTT|FIGO Stage IVC Gestational Trophoblastic Neoplasm
C6408	Orbit_Paraganglioma	Head_and_Neck_Paraganglioma|Orbit_Neoplasm	Orbit Paraganglioma|Orbital Paraganglioma|Paraganglioma of Orbit|Paraganglioma of the Orbit	A benign or malignant extra-adrenal paraganglioma arising from the orbit.  Patients may present with visual disturbances or proptosis.
C6409	Laryngeal_Paraganglioma	Head_and_Neck_Paraganglioma|Laryngeal_Neuroendocrine_Neoplasm|Parasympathetic_Paraganglioma	Laryngeal Paraganglioma|Larynx Paraganglioma|Paraganglioma of Larynx|Paraganglioma of the Larynx	A benign or malignant extra-adrenal parasympathetic paraganglioma arising from paraganglia adjacent to the larynx.  Patients may present with hoarseness and dysphagia.
C6410	Cardiac_Paraganglioma	Cardiac_Neoplasm|Extra-Adrenal_Paraganglioma	Cardiac Paraganglioma|Heart Paraganglioma|Paraganglioma of Heart|Paraganglioma of the Heart	A benign or malignant extra-adrenal paraganglioma arising from paraganglia located in the heart.
C6411	Intrathoracic_Paravertebral_Paraganglioma	Extra-Adrenal_Sympathetic_Paraganglioma|Thoracic_Neoplasm	Intrathoracic Paravertebral Paraganglioma	A benign or malignant intrathoracic sympathetic paraganglioma arising from paravertebral paraganglia.  In functional tumors, the hypersecretion of catecholamines results in hypertension.
C6413	Malignant_Intrathoracic_Paravertebral_Paraganglioma	Intrathoracic_Paravertebral_Paraganglioma|Malignant_Extra-Adrenal_Paraganglioma|Malignant_Thoracic_Neoplasm	Malignant Intrathoracic Paravertebral Paraganglioma	An intrathoracic paravertebral paraganglioma that metastasizes to other anatomic sites.
C6414	Bladder_Paraganglioma	Bladder_Neoplasm|Extra-Adrenal_Sympathetic_Paraganglioma|Urogenital_System_Paraganglioma	Bladder Paraganglioma|Paraganglioma of Bladder|Paraganglioma of Urinary Bladder|Paraganglioma of the Bladder|Paraganglioma of the Urinary Bladder|Urinary Bladder Paraganglioma	A benign or malignant extra-adrenal sympathetic paraganglioma arising from the urinary bladder.  Clinical signs include hypertension and hematuria.
C6416	Malignant_Bladder_Paraganglioma	Bladder_Paraganglioma|Malignant_Bladder_Neoplasm|Malignant_Extra-Adrenal_Paraganglioma	Malignant Bladder Paraganglioma|Malignant Paraganglioma of Bladder|Malignant Paraganglioma of Urinary Bladder|Malignant Paraganglioma of the Bladder|Malignant Paraganglioma of the Urinary Bladder|Malignant Urinary Bladder Paraganglioma	An extra-adrenal sympathetic paraganglioma of the bladder that metastasizes to other anatomic sites.
C6417	Recurrent_Adrenal_Cortex_Cancer	Adrenal_Cortex_Carcinoma|Recurrent_Carcinoma	Recurrent Adrenal Cortex Cancer|Recurrent Adrenal Cortex Carcinoma|Recurrent Adrenocortical Carcinoma|Recurrent Carcinoma of Adrenal Cortex|Recurrent Carcinoma of the Adrenal Cortex|Relapsed Adrenal Cortex Carcinoma|Relapsed Adrenocortical Carcinoma|Relapsed Carcinoma of Adrenal Cortex|Relapsed Carcinoma of the Adrenal Cortex	The reemergence of adrenal cortex carcinoma after a period of remission. (NCI05)
C6419	Ovarian_Liposarcoma	Liposarcoma|Ovarian_Sarcoma	Ovarian Liposarcoma|Liposarcoma of Ovary|Liposarcoma of the Ovary
C6420	Aortic_Paraganglioma	Retired_Concepts	Aortic Paraganglioma|Paraganglioma of Aorta|Paraganglioma of the Aorta
C6421	Foregut_Carcinoid_Tumor	Carcinoid_Tumor	Foregut Carcinoid Tumor|Foregut Carcinoid Neoplasm
C6422	Midgut_Carcinoid_Tumor	Carcinoid_Tumor	Midgut Carcinoid Tumor|Midgut Carcinoid Neoplasm
C6423	Hindgut_Carcinoid_Tumor	Carcinoid_Tumor	Hindgut Carcinoid Tumor|Hindgut Carcinoid Neoplasm
C6424	Meckel_s_Diverticulum_Carcinoid_Tumor	Intestinal_Carcinoid_Tumor|Midgut_Carcinoid_Tumor	Meckel's Diverticulum Carcinoid Tumor|Carcinoid Neoplasm of Meckel's Diverticulum|Carcinoid Neoplasm of the Meckel's Diverticulum|Carcinoid Tumor of Meckel's Diverticulum|Carcinoid Tumor of the Meckel's Diverticulum|Meckel's Diverticulum Carcinoid Neoplasm
C6425	Duodenal_Carcinoid_Tumor	Foregut_Carcinoid_Tumor|Malignant_Duodenal_Neoplasm|Small_Intestinal_Carcinoid_Tumor	Duodenal Carcinoid Tumor|Carcinoid Neoplasm of Duodenum|Carcinoid Neoplasm of the Duodenum|Carcinoid Tumor of Duodenum|Carcinoid Tumor of the Duodenum|Duodenal Carcinoid Neoplasm
C6426	Transverse_Colon_Carcinoid_Tumor	Colon_Carcinoid_Tumor|Hindgut_Carcinoid_Tumor	Transverse Colon Carcinoid Tumor|Carcinoid Neoplasm of Transverse Colon|Carcinoid Neoplasm of the Transverse Colon|Carcinoid Tumor of Transverse Colon|Carcinoid Tumor of the Transverse Colon|Transverse Colon Carcinoid Neoplasm
C6427	Ascending_Colon_Carcinoid_Tumor	Colon_Carcinoid_Tumor|Midgut_Carcinoid_Tumor	Ascending Colon Carcinoid Tumor|Ascending Colon Carcinoid Neoplasm|Carcinoid Neoplasm of Ascending Colon|Carcinoid Neoplasm of the Ascending Colon|Carcinoid Tumor of Ascending Colon|Carcinoid Tumor of the Ascending Colon
C6428	Descending_Colon_Carcinoid_Tumor	Colon_Carcinoid_Tumor|Hindgut_Carcinoid_Tumor	Descending Colon Carcinoid Tumor|Carcinoid Neoplasm of Descending Colon|Carcinoid Neoplasm of the Descending Colon|Carcinoid Tumor of Descending Colon|Carcinoid Tumor of the Descending Colon|Descending Colon Carcinoid Neoplasm
C6429	Jejunal_Carcinoid_Tumor	Jejunal_Neoplasm|Midgut_Carcinoid_Tumor|Small_Intestinal_Carcinoid_Tumor	Jejunal Carcinoid Tumor|Carcinoid Neoplasm of Jejunum|Carcinoid Neoplasm of the Jejunum|Carcinoid Tumor of Jejunum|Carcinoid Tumor of the Jejunum|Jejunal Carcinoid Neoplasm
C6430	Thymus_Carcinoid_Tumor	Foregut_Carcinoid_Tumor|Thymoma_Type_C	Thymic Carcinoid Tumor|Carcinoid Neoplasm of Thymus|Carcinoid Neoplasm of the Thymus|Carcinoid Tumor of Thymus|Carcinoid Tumor of the Thymus|Thymic Carcinoid|Thymic Carcinoid Neoplasm|Thymus Carcinoid|Thymus Carcinoid Neoplasm|Thymus Carcinoid Tumor	A primary thymic neuroendocrine neoplasm, often associated with Cushing's syndrome.  Two morphologic subtypes are recognized: typical and atypical carcinoid tumors.  Atypical carcinoid tumors have a more aggressive clinical course. -- 2005
C6431	Metastatic_Carcinoid_Tumor	Carcinoid_Tumor	Metastatic Carcinoid Tumor|Metastatic Carcinoid Neoplasm
C6432	Multiple_Endocrine_Neoplasia	Endocrine_Neoplasm	Multiple Endocrine Neoplasia|MEN|Multiple Endocrine Adenomatosis|Multiple Endocrine Adenomatosis NOS|Multiple Endocrine Neoplasia Syndrome|multiple endocrine neoplasia syndrome	An inherited tendency to develop thyroid cancer and other cancers of the endocrine system. The altered gene can be detected with a blood test.
C6433	Endometrial_Polyp	Benign_Endometrial_Neoplasm|Neoplastic_Polyp|Uterine_Polyp	Endometrial Polyp|Polyp of Endometrium|Polyp of the Endometrium
C6434	Bartholin_s_Gland_Neoplasm	Vulvar_Neoplasm	Bartholin's Gland Neoplasm|Bartholin's Gland Tumor|Neoplasm of Bartholin's Gland|Neoplasm of the Bartholin's Gland|Tumor of Bartholin's Gland|Tumor of the Bartholin's Gland
C6437	Mediastinal_Germ_Cell_Neoplasm	Extragonadal_Germ_Cell_Neoplasm|Mediastinal_Neoplasm	Mediastinal Germ Cell Tumor|Germ Cell Neoplasm of Mediastinum|Germ Cell Neoplasm of the Mediastinum|Germ Cell Tumor of Mediastinum|Germ Cell Tumor of the Mediastinum|Mediastinal Germ Cell Neoplasm
C6438	Mediastinal_Teratoma	Mediastinal_Germ_Cell_Neoplasm|Teratoma	Mediastinal Teratoma|Teratoma of Mediastinum|Teratoma of the Mediastinum
C6439	Mediastinal_Malignant_Non-Seminomatous_Germ_Cell_Neoplasm	Malignant_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor|Malignant_Mediastinal_Germ_Cell_Neoplasm	Mediastinal Malignant Non-Seminomatous Germ Cell Tumor|Mediastinal Malignant Non-Seminomatous Germ Cell Neoplasm|Non-Seminomatous Malignant Germ Cell Neoplasm of Mediastinum|Non-Seminomatous Malignant Germ Cell Neoplasm of the Mediastinum|Non-Seminomatous Malignant Germ Cell Tumor of Mediastinum|Non-Seminomatous Malignant Germ Cell Tumor of the Mediastinum
C6440	Mediastinal_Choriocarcinoma	Choriocarcinoma|Mediastinal_Malignant_Non-Seminomatous_Germ_Cell_Neoplasm	Mediastinal Choriocarcinoma|Choriocarcinoma of Mediastinum|Choriocarcinoma of the Mediastinum
C6441	Mediastinal_Embryonal_Carcinoma	Extragonadal_Embryonal_Carcinoma|Mediastinal_Malignant_Non-Seminomatous_Germ_Cell_Neoplasm	Mediastinal Embryonal Carcinoma|Embryonal Carcinoma of Mediastinum|Embryonal Carcinoma of the Mediastinum
C6442	Mediastinal_Mixed_Embryonal_Carcinoma_and_Teratoma	Mediastinal_Malignant_Non-Seminomatous_Germ_Cell_Neoplasm	Mediastinal Mixed Embryonal Carcinoma and Teratoma|Mediastinal Teratocarcinoma|Mixed Embryonal Carcinoma and Teratoma of Mediastinum|Mixed Embryonal Carcinoma and Teratoma of the Mediastinum|Teratocarcinoma of Mediastinum|Teratocarcinoma of the Mediastinum
C6443	Mediastinal_Yolk_Sac_Tumor	Mediastinal_Malignant_Non-Seminomatous_Germ_Cell_Neoplasm|Yolk_Sac_Tumor	Mediastinal Yolk Sac Tumor|Endodermal Sinus Neoplasm of Mediastinum|Endodermal Sinus Neoplasm of the Mediastinum|Endodermal Sinus Tumor of Mediastinum|Endodermal Sinus Tumor of the Mediastinum|Mediastinal Endodermal Sinus Neoplasm|Mediastinal Endodermal Sinus Tumor|Mediastinal Yolk Sac Neoplasm|Yolk Sac Neoplasm of Mediastinum|Yolk Sac Neoplasm of the Mediastinum|Yolk Sac Tumor of Mediastinum|Yolk Sac Tumor of the Mediastinum
C6444	Mediastinal_Mixed_Non-Seminomatous_Germ_Cell_Neoplasm	Mediastinal_Malignant_Non-Seminomatous_Germ_Cell_Neoplasm	Mediastinal Mixed Non-Seminomatous Germ Cell Tumor|Mediastinal Mixed Non-Seminomatous Germ Cell Neoplasm|Mixed Non-Seminomatous Germ Cell Neoplasm of Mediastinum|Mixed Non-Seminomatous Germ Cell Neoplasm of the Mediastinum|Mixed Non-Seminomatous Germ Cell Tumor of Mediastinum|Mixed Non-Seminomatous Germ Cell Tumor of the Mediastinum
C6445	Benign_Mediastinal_Germ_Cell_Neoplasm	Benign_Extragonadal_Germ_Cell_Neoplasm|Benign_Mediastinal_Neoplasm|Mediastinal_Germ_Cell_Neoplasm	Mediastinal Benign Germ Cell Tumor|Benign Germ Cell Neoplasm of Mediastinum|Benign Germ Cell Neoplasm of the Mediastinum|Benign Germ Cell Tumor of Mediastinum|Benign Germ Cell Tumor of the Mediastinum|Benign Mediastinal Germ Cell Neoplasm
C6446	Malignant_Mediastinal_Germ_Cell_Neoplasm	Malignant_Extragonadal_Germ_Cell_Tumor|Malignant_Mediastinal_Neoplasm|Mediastinal_Germ_Cell_Neoplasm	Mediastinal Malignant Germ Cell Tumor|Malignant Germ Cell Neoplasm of Mediastinum|Malignant Germ Cell Neoplasm of the Mediastinum|Malignant Germ Cell Tumor of Mediastinum|Malignant Germ Cell Tumor of the Mediastinum|Malignant Mediastinal Germ Cell Neoplasm
C6447	Retroperitoneal_Germ_Cell_Neoplasm	Extragonadal_Germ_Cell_Neoplasm|Retroperitoneal_Neoplasm	Retroperitoneal Germ Cell Tumor|Germ Cell Neoplasm of Retroperitoneum|Germ Cell Neoplasm of the Retroperitoneum|Germ Cell Tumor of Retroperitoneum|Germ Cell Tumor of the Retroperitoneum|Retroperitoneal Germ Cell Neoplasm
C6448	Gastric_Germ_Cell_Neoplasm	Extragonadal_Germ_Cell_Neoplasm|Gastric_Neoplasm	Gastric Germ Cell Tumor|Gastric Germ Cell Neoplasm|Germ Cell Neoplasm of Stomach|Germ Cell Neoplasm of the Stomach|Germ Cell Tumor of Stomach|Germ Cell Tumor of the Stomach|Stomach Germ Cell Neoplasm|Stomach Germ Cell Tumor
C6449	Benign_Germ_Cell_Neoplasm	Germ_Cell_Neoplasm	Benign Germ Cell Tumor|Benign Germ Cell Neoplasm|Benign Neoplasm of Germ Cell|Benign Neoplasm of the Germ Cell|Benign Tumor of Germ Cell|Benign Tumor of the Germ Cell
C6450	Thymus_Epithelial_Neoplasm	Epithelial_Neoplasm|Thymic_Neoplasm	Thymus Epithelial Neoplasm|Epithelial Neoplasm of Thymus|Epithelial Neoplasm of the Thymus|Epithelial Tumor of Thymus|Epithelial Tumor of the Thymus|Thymic Epithelial Tumor|Thymic Epithelium Neoplasm|Thymus Epithelial Tumor
C6451	Thymic_Lymphoma	Malignant_Thymus_Neoplasm|Mediastinal_Lymphoma	Thymic Lymphoma|Lymphoma of Thymus|Lymphoma of the Thymus|Primary Thymic Lymphoma|Thymus Lymphoma
C6452	Thymic_Lipoma	Benign_Thymus_Neoplasm	Thymolipoma|Thymolipomatous Hamartoma
C6453	Invasive_Thymoma	Thymoma	Invasive Thymoma|Infiltrating Thymoma	A thymoma of any morphologic type that extends beyond the capsule and infiltrates the surrounding tissues.  --2003
C6454	Thymoma_Type_A	Thymoma	Thymoma Type A|Medullary Thymoma|Spindle Cell Thymoma
C6455	Squamous_Cell_Thymic_Carcinoma	Squamous_Cell_Carcinoma|Thymoma_Type_C	Thymic Squamous Cell Carcinoma|Epidermoid Thymic Carcinoma|Squamous Cell Carcinoma of Thymus|Squamous Cell Carcinoma of the Thymus|Thymus Squamous Cell Carcinoma	A rare primary thymic carcinoma, characterized by the presence of keratinizing or non-keratinizing malignant squamous cells.  Approximately 10-20% of cases occur in combination with thymoma.  The prognosis depends on the tumor stage and the degree of cellular differentiation. -- 2005
C6456	Basaloid_Thymic_Carcinoma	Basaloid_Carcinoma|Squamous_Cell_Thymic_Carcinoma	Thymic Basaloid Carcinoma|Basaloid Carcinoma of Thymus|Basaloid Carcinoma of the Thymus|Thymus Basaloid Carcinoma	A rare primary thymic carcinoma, characterized by the presence of tumor cell lobules with peripheral palisading, and a basophilic staining pattern.  More than half of reported cases were associated with the presence of a multilocular thymic cyst.  Metastases to lung and liver have been reported in approximately 30% of cases. -- 2005
C6457	Mucoepidermoid_Thymic_Carcinoma	Mucoepidermoid_Carcinoma|Thymoma_Type_C	Thymic Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Thymus|Mucoepidermoid Carcinoma of the Thymus|Thymus Mucoepidermoid Carcinoma	A rare primary thymic carcinoma, characterized by the presence of squamous cells, intermediate type cells, and mucus-producing cells.  Published information on clinical course is limited to single-case reports. -- 2005
C6458	Adenosquamous_Thymic_Carcinoma	Adenosquamous_Carcinoma|Thymoma_Type_C	Thymic Adenosquamous Carcinoma|Adenosquamous Carcinoma of Thymus|Adenosquamous Carcinoma of the Thymus|Thymus Adenosquamous Carcinoma
C6459	Thymic_Adenocarcinoma	Adenocarcinoma|Thymoma_Type_C	Thymic Adenocarcinoma|Adenocarcinoma of Thymus|Adenocarcinoma of the Thymus|Thymus Adenocarcinoma	A rare primary thymic carcinoma, characterized by the presence of carcinoma cells with glandular differentiation. -- 2005
C6460	Small_Cell_Thymic_Carcinoma	Small_Cell_Carcinoma|Thymoma_Type_C	Thymic Small Cell Carcinoma|Small Cell Carcinoma of Thymus|Small Cell Carcinoma of the Thymus|Thymic Small Cell Carcinoma Neuroendocrine Type|Thymus Small Cell Carcinoma	An aggressive, small cell, poorly differentiated thymic neuroendocrine carcinoma, characterized by the presence of a high mitotic rate and numerous apoptotic bodies. -- 2005
C6461	Large_Cell_Thymic_Carcinoma	Large_Cell_Carcinoma|Thymoma_Type_C	Thymic Large Cell Neuroendocrine Carcinoma|Large Cell Neuroendocrine Carcinoma of Thymus|Large Cell Neuroendocrine Carcinoma of the Thymus|Thymus Large Cell Carcinoma	An aggressive, non-small cell, poorly differentiated thymic neuroendocrine carcinoma, characterized by the presence of a high mitotic rate and, almost always, necrosis. -- 2005
C6462	Clear_Cell_Thymic_Carcinoma	Thymoma_Type_C	Thymic Clear Cell Carcinoma|Clear Cell Carcinoma of Thymus|Clear Cell Carcinoma of the Thymus|Thymus Clear Cell Carcinoma	A rare, usually aggressive, primary thymic carcinoma, characterized by the presence of carcinoma cells with clear cytoplasm.
C6463	Sarcomatoid_Thymic_Carcinoma	Sarcomatoid_Carcinoma|Thymoma_Type_C	Thymic Sarcomatoid Carcinoma|Sarcomatoid Carcinoma of Thymus|Sarcomatoid Carcinoma of the Thymus|Thymic Carcinosarcoma|Thymic Spindle Cell Carcinoma|Thymus Sarcomatoid Carcinoma	A rare, usually aggressive, primary thymic carcinoma, characterized by the presence of tumor cells morphologically resembling soft tissue sarcoma. -- 2005
C6464	Stage_IA_Bone_Sarcoma	Stage_I_Bone_Sarcoma	Stage IA Bone Sarcoma|Stage IA Sarcoma of Bone|Stage IA Sarcoma of the Bone
C6465	Stage_IB_Bone_Sarcoma	Stage_I_Bone_Sarcoma	Stage IB Bone Sarcoma|Stage IB Sarcoma of Bone|Stage IB Sarcoma of the Bone
C6466	Stage_IIB_Bone_Sarcoma	Stage_II_Bone_Sarcoma	Stage IIB Bone Sarcoma|Stage IIB Sarcoma of Bone|Stage IIB Sarcoma of the Bone
C6467	Stage_IIA_Bone_Sarcoma	Stage_II_Bone_Sarcoma	Stage IIA Bone Sarcoma|Stage IIA Sarcoma of Bone|Stage IIA Sarcoma of the Bone
C6468	Stage_III_Bone_Sarcoma	Bone_Sarcoma	Stage III Bone Sarcoma|Stage III Sarcoma of Bone|Stage III Sarcoma of the Bone
C6469	Osteosarcoma_Arising_in_Paget_s_Disease_of_Bone	Primary_Bone_Osteosarcoma	Osteosarcoma Arising in Paget's Disease of Bone|Osteosarcoma Arising in Bone Paget's Disease|Osteosarcoma Arising in Osseous Paget's Disease|Osteosarcoma Arising in Osteitis Deformans
C6470	Multifocal_Osteosarcoma	Osteosarcoma|Primary_Bone_Osteosarcoma	Multifocal Osteosarcoma|Multifocal Osteogenic Sarcoma
C6471	Synchronous_Multifocal_Osteosarcoma	Multifocal_Osteosarcoma	Synchronous Multifocal Osteosarcoma|Synchronous Multifocal Osteogenic Sarcoma
C6472	Asynchronous_Multifocal_Osteosarcoma	Multifocal_Osteosarcoma	Asynchronous Multifocal Osteosarcoma|Asynchronous Multifocal Osteogenic Sarcoma
C6473	Intracortical_Osteosarcoma	Central_Osteosarcoma	Intracortical Osteosarcoma|Intracortical Osteogenic Sarcoma
C6474	Low_Grade_Central_Osteosarcoma	Central_Osteosarcoma	Low Grade Central Osteosarcoma|Intraosseous Well-Differentiated Osteogenic Sarcoma|Intraosseous Well-Differentiated Osteosarcoma
C6475	Clear_Cell_Chondrosarcoma	Chondrosarcoma	Clear Cell Chondrosarcoma	A rare usually low grade malignant mesenchymal neoplasm characterized by the presence of hyaline cartilage and clear cells.  It usually arises in the epiphyseal ends of long bones.
C6476	Dedifferentiated_Chondrosarcoma	Chondrosarcoma	Dedifferentiated Chondrosarcoma
C6477	Bone_Hemangioma	Benign_Bone_Neoplasm|Hemangioma|Vascular_Bone_Neoplasm	Bone Hemangioma|Angioma of Bone|Angioma of the Bone|Bone Angioma|Hemangioma of Bone|Hemangioma of the Bone|Osseous Angioma|Osseous Hemangioma
C6478	Vascular_Bone_Neoplasm	Bone_Neoplasm|Vascular_Neoplasm	Vascular Bone Neoplasm|Bone Vascular Neoplasm|Bone Vascular Tumor|Osseous Vascular Neoplasm|Osseous Vascular Tumor|Vascular Neoplasm of Bone|Vascular Neoplasm of the Bone|Vascular Tumor of Bone|Vascular Tumor of the Bone
C6479	Bone_Angiosarcoma	Angiosarcoma|Bone_Sarcoma|Vascular_Bone_Neoplasm	Bone Angiosarcoma|Bone Angioendothelial Sarcoma|Bone Hemangioendothelial Sarcoma|Bone Hemangiosarcoma|Osseous Angioendothelial Sarcoma|Osseous Angiosarcoma|Osseous Hemangiosarcoma
C6480	Bone_Glomus_Tumor	Benign_Bone_Neoplasm|Glomus_Tumor	Bone Glomus Tumor|Bone Glomus Neoplasm|Glomus Neoplasm of Bone|Glomus Neoplasm of the Bone|Glomus Tumor of Bone|Glomus Tumor of the Bone|Osseous Glomus Neoplasm|Osseous Glomus Tumor
C6481	Inflammatory_Myofibroblastic_Tumor	Intermediate_Fibrocytic_Neoplasm	Inflammatory Myofibroblastic Tumor|IMT|Inflammatory Fibrosarcoma|Inflammatory Myofibroblastic Neoplasm|Inflammatory Pseudotumor	The preferred term, according to the WHO classification, is "inflammatory myofibroblastic tumor" or IMT.  The term "inflammatory fibrosarcoma" is out of favor because it is not at all clear that these are sarcomas.  Right now they are considered neoplasms indeterminate or intermediate in biologic potential.
C6483	Atypical_Decubital_Fibroplasia	Benign_Fibrous_Soft_Tissue_Neoplasm	Atypical Decubital Fibroplasia|Ischemic Fasciitis
C6484	Dermal_Fibroma	Benign_Cutaneous_Fibrous_Neoplasm|Fibroma	Dermal Fibroma|Fibroma of Skin|Fibroma of the Skin|Skin Fibroma
C6485	Tendon_Sheath_Fibroma	Dermal_Fibroma	Tendon Sheath Fibroma|Fibroma of Tendon Sheath|Fibroma of the Tendon Sheath
C6486	Nuchal_Fibroma	Fibroma	Nuchal Fibroma
C6487	Multicentric_Myofibromatosis	Myofibromatosis	Multicentric Myofibromatosis
C6488	Calcifying_Fibrous_Pseudotumor	Benign_Fibrous_Soft_Tissue_Neoplasm	Calcifying Fibrous Pseudotumor
C6489	Extraabdominal_Fibromatosis	Deep_Fibromatosis_Desmoid_Tumor	Extraabdominal Fibromatosis|Extraabdominal Desmoid|Extraabdominal Desmoid Tumor
C6490	Benign_Fibrohistiocytic_Neoplasm	Benign_Soft_Tissue_Neoplasm|Fibrohistiocytic_Neoplasm	Benign Fibrohistiocytic Neoplasm|Benign Fibrohistiocytic Tumor	A benign mesenchymal neoplasm arising from fibrohistiocytic tissues.  The most common representative of this category is the benign fibrous histiocytoma. -- 2003
C6491	Intermediate_Fibrohistiocytic_Neoplasm	Fibrohistiocytic_Neoplasm|Intermediate_Soft_Tissue_Neoplasm	Intermediate Fibrohistiocytic Neoplasm|Intermediate Fibrohistiocytic Tumor	These fibrohistiocytic neoplasms typically affect younger patients, and are characterized by an increased risk of local recurrence and a low risk of metastasis. -- 2003
C6492	Benign_Deep_Fibrous_Histiocytoma	Benign_Fibrous_Histiocytoma	Benign Deep Fibrous Histiocytoma	A benign fibrous histiocytoma, morphologically similar to cutaneous fibrous histiocytoma.  It occurs in the deep soft tissues and less frequently in parenchymal organs. -- 2003
C6493	Plexiform_Fibrohistiocytic_Tumor	Intermediate_Cutaneous_Fibrohistiocytic_Neoplasm	Plexiform Fibrohistiocytic Tumor|Plexiform Fibrohistiocytic Neoplasm	An intermediate cutaneous fibrohistiocytic neoplasm typically affecting young patients, presenting as a slowly growing tumor mass of the dermis and the subcutaneous tissues.  This tumor frequently recurs, and rarely metastasizes. -- 2003
C6494	Angiomatoid_Fibrous_Histiocytoma	Intermediate_Fibrohistiocytic_Neoplasm	Angiomatoid Fibrous Histiocytoma	An intermediate fibrohistiocytic neoplasm typically affecting young patients, presenting as a slowly growing nodular or cystic tumor mass, most often in the subcutaneous tissues of the extremities.  Occasionally, patients have systemic symptoms (anemia, fever, and weight loss).  This tumor has a relatively good prognosis.  A minority of patients develop local recurrences.  Metastases are rare. -- 2003
C6495	Storiform-Pleomorphic_Malignant_Fibrous_Histiocytoma	Malignant_Fibrous_Histiocytoma|Sarcoma_Differentiation_Score_2	Storiform-Pleomorphic Malignant Fibrous Histiocytoma|Pleomorphic Malignant Fibrous Histiocytoma|Storiform-Pleomorphic Fibrous Histiocytoma|Storiform-Pleomorphic MFH|Undifferentiated High Grade Pleomorphic Sarcoma	A morphologic variant of malignant fibrous histiocytoma, characterized by a prominent storiform pattern and pleomorphic cells.  Males are affected more frequently than females.  The majority of patients present with deep large tumor masses in the extremities.  The clinical course is aggressive.  -- 2003
C6496	Myxoid_Malignant_Fibrous_Histiocytoma	Malignant_Fibrous_Histiocytoma|Sarcoma_Differentiation_Score_2|Sarcoma_NCI_Grade_2	Myxoid Malignant Fibrous Histiocytoma|Myxofibrosarcoma|Myxoid Fibrous Histiocytoma|Myxoid MFH	A less aggressive morphologic variant of malignant fibrous histiocytoma, characterized by extensive myxoid changes and cellular pleomorphism. -- 2003
C6497	Inflammatory_Malignant_Fibrous_Histiocytoma	Malignant_Fibrous_Histiocytoma|Sarcoma_Differentiation_Score_3	Inflammatory Malignant Fibrous Histiocytoma|Inflammatory MFH|Malignant Xanthogranuloma|Xanthosarcoma	An aggressive morphologic variant of malignant fibrous histiocytoma, characterized by the presence of occasional atypical cells which are admixed with numerous inflammatory cells.  The most common site of involvement is the retroperitoneum. -- 2003
C6498	Deep_Lipoma	Lipoma	Deep Lipoma|Deep Fatty Neoplasm|Deep Fatty Tumor
C6499	Tendon_Sheath_Lipoma	Deep_Lipoma	Tendon Sheath Lipoma|Lipoma of Tendon Sheath|Lipoma of the Tendon Sheath
C6500	Lumbosacral_Lipoma	Deep_Lipoma	Lumbosacral Lipoma
C6503	Chondroid_Lipoma	Lipoma	Chondroid Lipoma	This type of lipoma is characterized by the presence of mature adipose (fatty) tissue and islands of cells resembling lipoblasts and chondroblasts. -- 2003
C6504	Diffuse_Lipomatosis	Lipomatosis	Diffuse Lipomatosis
C6505	Atypical_Lipoma	Intermediate_Lipomatous_Neoplasm	Atypical Lipoma|Lipoma-Like Liposarcoma|Superficial Well Differentiated Liposarcoma|Well Differentiated Liposarcoma of Superficial Soft Tissue	Also known as superficial well differentiated liposarcoma, or lipoma-like liposarcoma, this is an intermediate lipomatous neoplasm that may recur locally.  It requires a wide local excision, but never metastasizes.  Microscopically, the adipose tissue contains large and pleomorphic lipoblasts, and is dissected by fibrous septa containing spindle cells. -- 2003
C6507	Sclerosing_Liposarcoma	Well-Differentiated_Liposarcoma	Sclerosing Liposarcoma
C6508	Inflammatory_Liposarcoma	Well-Differentiated_Liposarcoma	Inflammatory Liposarcoma
C6509	Fibroblastic_Liposarcoma	Liposarcoma	Fibroblastic Liposarcoma
C6510	Benign_Smooth_Muscle_Neoplasm	Benign_Muscle_Neoplasm|Smooth_Muscle_Neoplasm	Benign Smooth Muscle Neoplasm|Benign Neoplasm of Smooth Muscle|Benign Neoplasm of the Smooth Muscle|Benign Smooth Muscle Tumor|Benign Tumor of Smooth Muscle|Benign Tumor of the Smooth Muscle
C6511	Malignant_Smooth_Muscle_Neoplasm	Malignant_Muscle_Neoplasm|Smooth_Muscle_Neoplasm	Malignant Smooth Muscle Neoplasm|Cancer of Smooth Muscle|Cancer of the Smooth Muscle|Malignant Neoplasm of Smooth Muscle|Malignant Neoplasm of the Smooth Muscle|Malignant Smooth Muscle Tumor|Malignant Tumor of Smooth Muscle|Malignant Tumor of the Smooth Muscle|Smooth Muscle Cancer	A malignant neoplasm arising from smooth muscle. -- 2003
C6512	Deep_Leiomyoma	Leiomyoma	Deep Leiomyoma
C6513	Pleomorphic_Leiomyoma	Leiomyoma	Pleomorphic Leiomyoma
C6514	Skeletal_Muscle_Neoplasm	Myomatous_Neoplasm	Skeletal Muscle Neoplasm|Neoplasm of Skeletal Muscle|Neoplasm of the Skeletal Muscle|Skeletal Muscle Tumor|Tumor of Skeletal Muscle|Tumor of the Skeletal Muscle	A benign or malignant mesenchymal neoplasm arising from skeletal muscle. -- 2003
C6515	Benign_Skeletal_Muscle_Neoplasm	Benign_Muscle_Neoplasm|Skeletal_Muscle_Neoplasm	Benign Skeletal Muscle Neoplasm|Benign Neoplasm of Skeletal Muscle|Benign Neoplasm of the Skeletal Muscle|Benign Skeletal Muscle Tumor|Benign Tumor of Skeletal Muscle|Benign Tumor of the Skeletal Muscle
C6516	Malignant_Skeletal_Muscle_Neoplasm	Malignant_Muscle_Neoplasm|Skeletal_Muscle_Neoplasm	Malignant Skeletal Muscle Neoplasm|Malignant Neoplasm of Skeletal Muscle|Malignant Neoplasm of the Skeletal Muscle|Malignant Skeletal Muscle Tumor|Malignant Tumor of Skeletal Muscle|Malignant Tumor of the Skeletal Muscle
C6517	Genital_Rhabdomyoma	Rhabdomyoma	Genital Rhabdomyoma
C6518	Intermediate_Rhabdomyoma	Fetal_Rhabdomyoma|Intermediate_Soft_Tissue_Neoplasm	Intermediate Rhabdomyoma|Cellular Rhabdomyoma
C6519	Spindle_Cell_Rhabdomyosarcoma	Embryonal_Rhabdomyosarcoma	Spindle Cell Rhabdomyosarcoma
C6522	Benign_Testicular_Sertoli_Cell_Tumor	Benign_Endocrine_Neoplasm|Benign_Testicular_Neoplasm|Testicular_Sertoli_Cell_Tumor	Benign Testicular Sertoli Cell Tumor|Benign Sertoli Cell Neoplasm of Testis|Benign Sertoli Cell Neoplasm of the Testis|Benign Sertoli Cell Tumor of Testis|Benign Sertoli Cell Tumor of the Testis|Benign Testicular Sertoli Cell Neoplasm
C6523	Malignant_Testicular_Sertoli_Cell_Tumor	Testicular_Sertoli_Cell_Tumor	Malignant Testicular Sertoli Cell Tumor|Malignant Sertoli Cell Neoplasm of Testis|Malignant Sertoli Cell Neoplasm of the Testis|Malignant Sertoli Cell Tumor of Testis|Malignant Sertoli Cell Tumor of the Testis|Malignant Testicular Sertoli Cell Neoplasm
C6524	Benign_Lymphatic_Vessel_Neoplasm	Benign_Vascular_Neoplasm|Lymphatic_Vessel_Neoplasm	Benign Lymphatic Vessel Neoplasm|Benign Lymph Vessel Neoplasm|Benign Lymph Vessel Tumor|Benign Lymphatic Vessel Tumor|Benign Neoplasm of Lymph Vessel|Benign Neoplasm of Lymphatic Vessel|Benign Neoplasm of the Lymph Vessel|Benign Neoplasm of the Lymphatic Vessel|Benign Tumor of Lymph Vessel|Benign Tumor of Lymphatic Vessel|Benign Tumor of the Lymph Vessel|Benign Tumor of the Lymphatic Vessel
C6525	Synovial_Hemangioma	Benign_Synovial_Neoplasm|Deep_Hemangioma	Synovial Hemangioma|Angioma of Synovium|Angioma of the Synovium|Hemangioma of Synovium|Hemangioma of the Synovium|Synovial Angioma
C6526	Perineural_Hemangioma	Deep_Hemangioma	Perineural Hemangioma|Perineural Angioma
C6527	Alloimmunization	Transplant-Related_Disorder	Alloimmunization	Alloimmunization is an immune response to foreign (donor) antigens.
C6528	Perivascular_Neoplasm	Mesenchymal_Cell_Neoplasm	Perivascular Neoplasm|Perivascular Tumor
C6529	Benign_Perivascular_Neoplasm	Benign_Soft_Tissue_Neoplasm|Perivascular_Neoplasm	Benign Perivascular Neoplasm|Benign Perivascular Tumor
C6530	Malignant_Perivascular_Neoplasm	Perivascular_Neoplasm	Malignant Perivascular Neoplasm|Malignant Perivascular Tumor
C6531	Malignant_Synovial_Neoplasm	Malignant_Soft_Tissue_Neoplasm|Synovial_Neoplasm	Malignant Synovial Neoplasm|Malignant Neoplasm of Synovium|Malignant Neoplasm of the Synovium|Malignant Synovial Tumor|Malignant Tumor of Synovium|Malignant Tumor of the Synovium
C6532	Localized_Giant_Cell_Tumor_of_Tendon_Sheath	Benign_Synovial_Neoplasm|Giant_Cell_Tumor_of_Tendon_Sheath	Localized Giant Cell Tumor of Tendon Sheath|Localized Giant Cell Neoplasm of Tendon Sheath|Localized Giant Cell Neoplasm of Tenosynovium|Localized Giant Cell Neoplasm of the Tenosynovium|Localized Giant Cell Tumor of Tenosynovium|Localized Giant Cell Tumor of the Tenosynovium|Localized Tenosynovial Giant Cell Neoplasm|Localized Tenosynovial Giant Cell Tumor|Nodular Tenosynovitis
C6533	Fibrous_Synovial_Sarcoma	Synovial_Sarcoma	Fibrous Synovial Sarcoma|Fibrous Sarcoma of Synovium|Fibrous Sarcoma of the Synovium
C6534	Monophasic_Synovial_Sarcoma	Sarcoma_Differentiation_Score_3|Synovial_Sarcoma	Monophasic Synovial Sarcoma|Monophasic Sarcoma of Synovium|Monophasic Sarcoma of the Synovium
C6535	Malignant_Giant_Cell_Tumor_of_Tendon_Sheath	Giant_Cell_Tumor_of_Tendon_Sheath|Malignant_Giant_Cell_Neoplasm|Malignant_Synovial_Neoplasm	Malignant Giant Cell Tumor of Tendon Sheath|Malignant Giant Cell Neoplasm of Tendon Sheath|Malignant Giant Cell Neoplasm of the Tendon Sheath|Malignant Giant Cell Tumor of the Tendon Sheath|Malignant Tendon Sheath Giant Cell Neoplasm|Malignant Tendon Sheath Giant Cell Tumor
C6536	Multicystic_Peritoneal_Mesothelioma	Cystic_Mesothelioma|Peritoneal_Mesothelioma	Peritoneal Multicystic Mesothelioma|Multicystic Mesothelioma of Peritoneum|Multicystic Mesothelioma of the Peritoneum
C6537	Stage_I_Soft_Tissue_Sarcoma	Soft_Tissue_Sarcoma	Stage I Soft Tissue Sarcoma|Stage I Sarcoma of Soft Tissue|Stage I Sarcoma of the Soft Tissue
C6538	Stage_II_Soft_Tissue_Sarcoma	Soft_Tissue_Sarcoma	Stage II Soft Tissue Sarcoma|Stage II Sarcoma of Soft Tissue|Stage II Sarcoma of the Soft Tissue
C6539	Childhood_Testicular_Mixed_Embryonal_Carcinoma_and_Teratoma	Childhood_Testicular_Mixed_Germ_Cell_Neoplasm	Childhood Testicular Mixed Embryonal Carcinoma and Teratoma|Childhood Teratocarcinoma of Testis|Childhood Teratocarcinoma of the Testis|Childhood Testicular Teratocarcinoma|Pediatric Testicular Teratocarcinoma
C6540	Childhood_Testicular_Teratoma	Childhood_Testicular_Germ_Cell_Tumor|Testicular_Teratoma	Childhood Testicular Teratoma|Childhood Teratoma of Testis|Childhood Teratoma of the Testis|Pediatric Testicular Teratoma
C6541	Malignant_Childhood_Germ_Cell_Tumor	Childhood_Germ_Cell_Neoplasm|Malignant_Germ_Cell_Neoplasm	Malignant Childhood Germ Cell Tumor|Malignant Childhood Germ Cell Neoplasm|Malignant Pediatric Germ Cell Neoplasm|Malignant Pediatric Germ Cell Tumor
C6542	Childhood_Testicular_Mixed_Germ_Cell_Neoplasm	Childhood_Testicular_Germ_Cell_Tumor|Testicular_Mixed_Germ_Cell_Neoplasm	Childhood Testicular Mixed Germ Cell Neoplasm|Childhood Testicular Mixed Germ Cell Tumor|Pediatric Testicular Mixed Germ Cell Neoplasm|Pediatric Testicular Mixed Germ Cell Tumor
C6543	Childhood_Testicular_Yolk_Sac_Tumor	Childhood_Testicular_Germ_Cell_Tumor|Childhood_Yolk_Sac_Tumor|Testicular_Yolk_Sac_Tumor	Childhood Testicular Yolk Sac Tumor|Childhood Testicular Endodermal Sinus Neoplasm|Childhood Testicular Endodermal Sinus Tumor|Childhood Testicular Yolk Sac Neoplasm|Pediatric Testicular Endodermal Sinus Neoplasm|Pediatric Testicular Endodermal Sinus Tumor|Pediatric Testicular Yolk Sac Neoplasm|Pediatric Testicular Yolk Sac Tumor
C6544	Childhood_Testicular_Choriocarcinoma	Childhood_Testicular_Germ_Cell_Tumor|Testicular_Choriocarcinoma	Childhood Testicular Choriocarcinoma|Childhood Choriocarcinoma of Testis|Childhood Choriocarcinoma of the Testis|Pediatric Choriocarcinoma of Testis|Pediatric Choriocarcinoma of the Testis|Pediatric Testicular Choriocarcinoma
C6545	Childhood_Testicular_Embryonal_Carcinoma	Childhood_Testicular_Germ_Cell_Tumor|Testicular_Embryonal_Carcinoma	Childhood Testicular Embryonal Carcinoma|Childhood Embryonal Carcinoma of Testis|Childhood Embryonal Carcinoma of the Testis|Pediatric Embryonal Carcinoma of Testis|Pediatric Embryonal Carcinoma of the Testis|Pediatric Testicular Embryonal Carcinoma
C6546	Childhood_Ovarian_Embryonal_Carcinoma	Childhood_Ovarian_Germ_Cell_Tumor|Ovarian_Embryonal_Carcinoma	Childhood Ovarian Embryonal Carcinoma|Childhood Embryonal Carcinoma of Ovary|Childhood Embryonal Carcinoma of the Ovary|Pediatric Embryonal Carcinoma of Ovary|Pediatric Embryonal Carcinoma of the Ovary|Pediatric Ovarian Embryonal Carcinoma
C6547	Childhood_Ovarian_Immature_Teratoma	Childhood_Ovarian_Teratoma|Immature_Ovarian_Teratoma	Childhood Ovarian Immature Teratoma|Childhood Immature Teratoma of Ovary|Childhood Immature Teratoma of the Ovary|Pediatric Immature Teratoma of Ovary|Pediatric Immature Teratoma of the Ovary|Pediatric Ovarian Immature Teratoma
C6548	Childhood_Ovarian_Mature_Teratoma	Childhood_Ovarian_Teratoma|Mature_Ovarian_Teratoma	Childhood Ovarian Mature Teratoma|Childhood Mature Teratoma of Ovary|Childhood Mature Teratoma of the Ovary|Pediatric Mature Teratoma of Ovary|Pediatric Mature Teratoma of the Ovary|Pediatric Ovarian Mature Teratoma
C6549	Childhood_Ovarian_Choriocarcinoma	Childhood_Ovarian_Germ_Cell_Tumor|Ovarian_Choriocarcinoma	Childhood Ovarian Choriocarcinoma|Childhood Choriocarcinoma of Ovary|Childhood Choriocarcinoma of the Ovary|Pediatric Choriocarcinoma of Ovary|Pediatric Choriocarcinoma of the Ovary|Pediatric Ovarian Choriocarcinoma
C6550	Childhood_Ovarian_Dysgerminoma	Childhood_Ovarian_Germ_Cell_Tumor|Ovarian_Dysgerminoma	Childhood Ovarian Dysgerminoma|Pediatric Ovarian Dysgerminoma
C6551	Childhood_Ovarian_Yolk_Sac_Tumor	Childhood_Ovarian_Germ_Cell_Tumor|Childhood_Yolk_Sac_Tumor|Ovarian_Yolk_Sac_Tumor	Childhood Ovarian Yolk Sac Tumor|Childhood Ovarian Endodermal Sinus Neoplasm|Childhood Ovarian Endodermal Sinus Tumor|Childhood Ovarian Yolk Sac Neoplasm|Pediatric Ovarian Endodermal Sinus Neoplasm|Pediatric Ovarian Endodermal Sinus Tumor|Pediatric Ovarian Yolk Sac Neoplasm|Pediatric Ovarian Yolk Sac Tumor
C6552	Childhood_Testicular_Germ_Cell_Tumor	Childhood_Germ_Cell_Neoplasm|Childhood_Testicular_Neoplasm|Testicular_Germ_Cell_Neoplasm	Childhood Testicular Germ Cell Tumor|Childhood Testicular Germ Cell Neoplasm|Pediatric Testicular Germ Cell Neoplasm|Pediatric Testicular Germ Cell Tumor
C6553	Benign_Childhood_Germ_Cell_Neoplasm	Benign_Germ_Cell_Neoplasm|Childhood_Germ_Cell_Neoplasm	Benign Childhood Germ Cell Tumor|Benign Childhood Germ Cell Neoplasm|Benign Pediatric Germ Cell Neoplasm|Benign Pediatric Germ Cell Tumor
C6554	Childhood_Ovarian_Teratoma	Childhood_Ovarian_Germ_Cell_Tumor|Ovarian_Teratoma	Childhood Ovarian Teratoma|Childhood Teratoma of Ovary|Childhood Teratoma of the Ovary|Pediatric Ovarian Teratoma|Pediatric Teratoma of Ovary|Pediatric Teratoma of the Ovary
C6555	Deep_Hemangioma	Hemangioma	Deep Hemangioma|Deep Angioma
C6556	Degenerated_Schwannoma	Schwannoma	Degenerated Schwannoma|Ancient Neurilemmoma|Ancient Schwannoma|Degenerated Neurilemmoma
C6557	Schwannomatosis	Schwannoma	Schwannomatosis|Neurilemmomatosis
C6558	Epithelioid_Neurofibroma	Neurofibroma	Epithelioid Neurofibroma
C6559	Multiple_Mucosal_Neuromas	Neuroma	Multiple Mucosal Neuromas
C6560	Glandular_Malignant_Peripheral_Nerve_Sheath_Tumor	Malignant_Peripheral_Nerve_Sheath_Tumor	Glandular Malignant Peripheral Nerve Sheath Tumor|Glandular MPNST|Malignant Glandular Neoplasm of Peripheral Nerve Sheath|Malignant Glandular Neoplasm of the Peripheral Nerve Sheath|Malignant Glandular Peripheral Nerve Sheath Neoplasm|Malignant Glandular Peripheral Nerve Sheath Tumor|Malignant Glandular Schwannoma|Malignant Glandular Tumor of Peripheral Nerve Sheath|Malignant Glandular Tumor of the Peripheral Nerve Sheath
C6561	Epithelioid_Malignant_Peripheral_Nerve_Sheath_Tumor	Malignant_Peripheral_Nerve_Sheath_Tumor	Epithelioid Malignant Peripheral Nerve Sheath Tumor|Epithelioid MPNST|Malignant Epithelioid Neoplasm of Peripheral Nerve Sheath|Malignant Epithelioid Neoplasm of the Peripheral Nerve Sheath|Malignant Epithelioid Peripheral Nerve Sheath Neoplasm|Malignant Epithelioid Peripheral Nerve Sheath Tumor|Malignant Epithelioid Tumor of Peripheral Nerve Sheath|Malignant Epithelioid Tumor of the Peripheral Nerve Sheath	Epithelioid MPNST is a rare variant defined as Malignant Peripheral Nerve Sheath Tumor with a predominance of epithelioid cells. They show no association with NF1. (Adapted from WHO.)
C6563	Childhood_Renal_Neoplasm	Childhood_Neoplasm|Renal_Neoplasm	Childhood Renal Neoplasm|Childhood Kidney Neoplasm|Childhood Kidney Tumor|Childhood Renal Tumor|Pediatric Kidney Neoplasm|Pediatric Kidney Tumor|Pediatric Renal Neoplasm|Pediatric Renal Tumor
C6564	Childhood_Renal_Clear_Cell_Sarcoma	Retired_Concepts	Childhood Clear Cell Sarcoma of the Kidney|Childhood Kidney Clear Cell Sarcoma|Childhood Renal Clear Cell Sarcoma|Pediatric Kidney Clear Cell Sarcoma|Pediatric Renal Clear Cell Sarcoma
C6565	Childhood_Renal_Angiomyolipoma	Childhood_Renal_Neoplasm|Renal_Angiomyolipoma	Childhood Renal Angiomyolipoma|Childhood Kidney Angiomyolipoma|Pediatric Kidney Angiomyolipoma|Pediatric Renal Angiomyolipoma
C6566	Childhood_Multilocular_Cystic_Renal_Neoplasm	Childhood_Wilms_Tumor	Childhood Multilocular Cystic Renal Neoplasm|Childhood Multilocular Cystic Kidney Neoplasm|Childhood Multilocular Cystic Kidney Tumor|Childhood Multilocular Cystic Renal Tumor|Pediatric Multilocular Cystic Kidney Neoplasm|Pediatric Multilocular Cystic Kidney Tumor|Pediatric Multilocular Cystic Renal Neoplasm|Pediatric Multilocular Cystic Renal Tumor
C6568	Childhood_Renal_Cell_Carcinoma	Childhood_Renal_Neoplasm|Renal_Cell_Carcinoma	Childhood Renal Cell Carcinoma|Childhood Kidney Cell Carcinoma|Pediatric Kidney Cell Carcinoma|Pediatric Renal Cell Carcinoma
C6569	Childhood_Congenital_Mesoblastic_Nephroma	Childhood_Renal_Neoplasm|Mesoblastic_Nephroma	Congenital Mesoblastic Nephroma
C6570	Extraskeletal_Cartilaginous_and_Osseous_Neoplasm	Soft_Tissue_Neoplasm	Extraskeletal Cartilaginous and Osseous Neoplasm|Extraskeletal Cartilaginous and Osseous Tumor
C6571	Benign_Extraskeletal_Cartilaginous_and_Osseous_Neoplasm	Benign_Soft_Tissue_Neoplasm|Extraskeletal_Cartilaginous_and_Osseous_Neoplasm	Benign Extraskeletal Cartilaginous and Osseous Neoplasm|Benign Extraskeletal Cartilaginous and Osseous Tumor
C6572	Malignant_Extraskeletal_Cartilaginous_and_Osseous_Neoplasm	Extraskeletal_Cartilaginous_and_Osseous_Neoplasm|Soft_Tissue_Sarcoma	Malignant Extraskeletal Cartilaginous and Osseous Neoplasm|Malignant Extraskeletal Cartilaginous and Osseous Tumor
C6573	Fibroosseous_Pseudotumor_of_the_Digits	Non-Neoplastic_Soft_Tissue_Disorder	Fibroosseous Pseudotumor of the Digits|Fibroosseous Digital Pseudotumor|Fibroosseous Pseudotumor of Digits
C6574	Extraskeletal_Osteochondroma	Benign_Extraskeletal_Cartilaginous_and_Osseous_Neoplasm|Osteochondroma	Extraskeletal Osteochondroma
C6575	Extraskeletal_Osteoma	Benign_Extraskeletal_Cartilaginous_and_Osseous_Neoplasm|Osteoma	Extraskeletal Osteoma
C6577	Myxoma	Benign_Miscellaneous_Mesenchymal_Neoplasm	Myxoma
C6578	Cutaneous_Myxoma	Benign_Dermal_Neoplasm|Myxoma	Cutaneous Myxoma
C6579	Intramuscular_Myxoma	Myxoma	Intramuscular Myxoma
C6580	Juxtaarticular_Myxoma	Myxoma	Juxta-Articular Myxoma|Juxtaarticular Myxoma
C6581	Parachordoma	Benign_Miscellaneous_Mesenchymal_Neoplasm	Parachordoma
C6582	Ossifying_Fibromyxoid_Neoplasm	Benign_Miscellaneous_Mesenchymal_Neoplasm	Ossifying Fibromyxoid Neoplasm|Ossifying Fibromyxoid Tumor|Ossifying Fibromyxoma
C6583	Nonossifying_Fibromyxoid_Neoplasm	Benign_Miscellaneous_Mesenchymal_Neoplasm	Nonossifying Fibromyxoid Neoplasm|Nonossifying Fibromyxoid Tumor|Nonossifying Fibromyxoma
C6584	Palisaded_Lymph_Node_Myofibroblastoma	Benign_Miscellaneous_Mesenchymal_Neoplasm	Palisaded Lymph Node Myofibroblastoma|Palisaded Myofibroblastoma of Lymph Node|Palisaded Myofibroblastoma of the Lymph Node
C6585	Childhood_Osteosarcoma	Osteosarcoma	Childhood Osteosarcoma|Pediatric Osteosarcoma
C6586	Extrarenal_Rhabdoid_Tumor	Rhabdoid_Tumor	Extrarenal Rhabdoid Tumor|Malignant Extrarenal Rhabdoid Neoplasm
C6587	Benign_Miscellaneous_Mesenchymal_Neoplasm	Benign_Mesenchymal_Cell_Neoplasm|Miscellaneous_Mesenchymal_Neoplasm	Benign Miscellaneous Mesenchymal Neoplasm|Benign Miscellaneous Mesenchymal Tumor
C6588	Malignant_Miscellaneous_Mesenchymal_Neoplasm	Miscellaneous_Mesenchymal_Neoplasm	Malignant Miscellaneous Mesenchymal Neoplasm|Malignant Miscellaneous Mesenchymal Tumor
C6589	Childhood_Parosteal_Osteosarcoma	Childhood_Osteosarcoma|Parosteal_Osteosarcoma	Childhood Parosteal Osteosarcoma|Childhood Parosteal Osteogenic Sarcoma
C6590	Childhood_Intracortical_Osteosarcoma	Childhood_Osteosarcoma|Intracortical_Osteosarcoma	Childhood Intracortical Osteosarcoma
C6591	Peripheral_Neuroblastoma	Extracranial_Neuroblastoma	Peripheral Neuroblastoma
C6592	Panniculitis_Ossificans	Non-Neoplastic_Soft_Tissue_Disorder	Panniculitis Ossificans
C6593	Benign_Mesenchymal_Mediastinal_Neoplasm	Benign_Mediastinal_Neoplasm|Mediastinal_Mesenchymal_Neoplasm	Benign Mediastinal Mesenchymal Neoplasm|Benign Mesenchymal Mediastinal Tumor|Benign Mesenchymal Neoplasm of Mediastinum|Benign Mesenchymal Neoplasm of the Mediastinum|Benign Mesenchymal Tumor of Mediastinum|Benign Mesenchymal Tumor of the Mediastinum
C6594	Peripheral_Ganglioneuroblastoma	Ganglioneuroblastoma	Peripheral Ganglioneuroblastoma|PNS Ganglioneuroblastoma|Peripheral Nervous System Ganglioneuroblastoma
C6595	Mediastinal_Lymphangioma	Benign_Mesenchymal_Mediastinal_Neoplasm|Lymphangioma	Mediastinal Lymphangioma|Cystic Hygroma of Mediastinum|Cystic Hygroma of the Mediastinum|Lymphangioma of Mediastinum|Lymphangioma of the Mediastinum|Mediastinal Cystic Hygroma
C6596	Mediastinal_Chondroma	Benign_Mesenchymal_Mediastinal_Neoplasm|Extraskeletal_Chondroma	Mediastinal Chondroma|Chondroma of Mediastinum|Chondroma of the Mediastinum
C6597	Benign_Mediastinal_Hemangiopericytoma	Benign_Hemangiopericytoma|Benign_Mesenchymal_Mediastinal_Neoplasm	Benign Mediastinal Hemangiopericytoma|Benign Hemangiopericytoma of Mediastinum|Benign Hemangiopericytoma of the Mediastinum
C6598	Mediastinal_Leiomyoma	Benign_Mesenchymal_Mediastinal_Neoplasm|Leiomyoma	Mediastinal Leiomyoma|Leiomyoma of Mediastinum|Leiomyoma of the Mediastinum
C6599	Mediastinal_Lipoma	Benign_Mesenchymal_Mediastinal_Neoplasm|Lipoma	Mediastinal Lipoma|Lipoma of Mediastinum|Lipoma of the Mediastinum
C6600	Mediastinal_Rhabdomyoma	Benign_Mesenchymal_Mediastinal_Neoplasm|Rhabdomyoma	Mediastinal Rhabdomyoma|Rhabdomyoma of Mediastinum|Rhabdomyoma of the Mediastinum
C6601	Mediastinal_Granular_Cell_Tumor	Granular_Cell_Tumor|Mediastinal_Neoplasm	Mediastinal Granular Cell Tumor|Granular Cell Myoblastoma of Mediastinum|Granular Cell Myoblastoma of the Mediastinum|Granular Cell Neoplasm of Mediastinum|Granular Cell Neoplasm of the Mediastinum|Granular Cell Tumor of Mediastinum|Granular Cell Tumor of the Mediastinum|Mediastinal Granular Cell Myoblastoma|Mediastinal Granular Cell Neoplasm
C6602	Benign_Osteogenic_Neoplasm	Benign_Mesenchymal_Cell_Neoplasm|Osteogenic_Neoplasm	Benign Osteogenic Neoplasm|Benign Osseous Neoplasm|Benign Osseous Tumor|Benign Osteogenic Tumor
C6603	Osteogenic_Neoplasm	Mesenchymal_Cell_Neoplasm	Osteogenic Neoplasm|Osseous Neoplasm|Osseous Tumor|Osteogenic Tumor
C6604	Bone_Fibrosarcoma	Bone_Sarcoma|Fibrosarcoma	Bone Fibrosarcoma|Fibrosarcoma of Bone|Fibrosarcoma of the Bone
C6605	Soft_Tissue_Fibrosarcoma	Fibrosarcoma|Soft_Tissue_Sarcoma	Soft Tissue Fibrosarcoma|Fibrosarcoma of Soft Tissue|Fibrosarcoma of the Soft Tissue	A common soft tissue sarcoma of childhood (peaking in the 0-5 year range and the 10 to 15 year range) usually occurring in the distal extremities. This spindle cell tumor is notable histologically for a regular interweaving of tumor and normal cells.
C6606	Mediastinal_Sarcoma	Malignant_Mediastinal_Mesenchymal_Neoplasm|Soft_Tissue_Sarcoma	Mediastinal Sarcoma|Sarcoma of Mediastinum|Sarcoma of the Mediastinum
C6607	Stage_IA_Osteosarcoma	Stage_IA_Bone_Sarcoma|Stage_I_Osteosarcoma	Stage IA Osteosarcoma|Stage IA Osteogenic Sarcoma
C6608	Malignant_Mediastinal_Hemangiopericytoma	Malignant_Hemangiopericytoma|Malignant_Mediastinal_Mesenchymal_Neoplasm	Malignant Mediastinal Hemangiopericytoma|Malignant Hemangiopericytoma of Mediastinum|Malignant Hemangiopericytoma of the Mediastinum
C6609	Stage_IB_Osteosarcoma	Stage_IB_Bone_Sarcoma|Stage_I_Osteosarcoma	Stage IB Osteosarcoma|Stage IB Osteogenic Sarcoma
C6610	Stage_IIA_Osteosarcoma	Stage_IIA_Bone_Sarcoma|Stage_II_Osteosarcoma	Stage IIA Osteosarcoma|Stage IIA Osteogenic Sarcoma
C6611	Stage_IIB_Osteosarcoma	Stage_IIB_Bone_Sarcoma|Stage_II_Osteosarcoma	Stage IIB Osteosarcoma|Stage IIB Osteogenic Sarcoma
C6612	Stage_III_Osteosarcoma	Primary_Bone_Osteosarcoma|Stage_III_Bone_Sarcoma	Stage III Osteosarcoma|Stage III Osteogenic Sarcoma
C6613	Mediastinal_Angiosarcoma	Angiosarcoma|Mediastinal_Sarcoma	Mediastinal Angiosarcoma|Angiosarcoma of Mediastinum|Angiosarcoma of the Mediastinum|Hemangiosarcoma of Mediastinum|Hemangiosarcoma of the Mediastinum|Mediastinal Hemangiosarcoma
C6614	Mediastinal_Liposarcoma	Liposarcoma|Mediastinal_Sarcoma	Mediastinal Liposarcoma|Liposarcoma of Mediastinum|Liposarcoma of the Mediastinum
C6615	Mediastinal_Osteosarcoma	Extraskeletal_Osteosarcoma|Mediastinal_Sarcoma	Mediastinal Osteosarcoma|Mediastinal Osteogenic Sarcoma|Osteogenic Sarcoma of Mediastinum|Osteogenic Sarcoma of the Mediastinum|Osteosarcoma of Mediastinum|Osteosarcoma of the Mediastinum
C6617	Mediastinal_Rhabdomyosarcoma	Mediastinal_Sarcoma|Rhabdomyosarcoma	Mediastinal Rhabdomyosarcoma|Rhabdomyosarcoma of Mediastinum|Rhabdomyosarcoma of the Mediastinum
C6618	Mediastinal_Synovial_Sarcoma	Mediastinal_Sarcoma|Synovial_Sarcoma	Mediastinal Synovial Sarcoma|Synovial Sarcoma of Mediastinum|Synovial Sarcoma of the Mediastinum
C6619	Mediastinal_Leiomyosarcoma	Leiomyosarcoma|Mediastinal_Sarcoma	Mediastinal Leiomyosarcoma|Leiomyosarcoma of Mediastinum|Leiomyosarcoma of the Mediastinum
C6620	Bone_Lymphoma	Lymphoma_by_Site|Malignant_Bone_Neoplasm	Bone Lymphoma|Lymphoma of Bone|Lymphoma of the Bone|Primary Bone Lymphoma
C6621	Metastatic_Bone_Ewing_s_Sarcoma	Ewing_s_Sarcoma_of_Bone	Metastatic Bone Ewing's Sarcoma|Metastatic Ewing's Sarcoma of Bone|Metastatic Ewing's Sarcoma of the Bone|Metastatic Osseous Ewing's Sarcoma|Metastatic Skeletal Ewing's Sarcoma	Ewing's sarcoma which has spread from its initial site.
C6622	Recurrent_Bone_Ewing_s_Sarcoma	Ewing_s_Sarcoma_of_Bone	Recurrent Bone Ewing's Sarcoma|Recurrent Ewing's Sarcoma of Bone|Recurrent Ewing's Sarcoma of the Bone|Recurrent Osseous Ewing's Sarcoma|Recurrent Skeletal Ewing's Sarcoma|Relapsed Bone Ewing's Sarcoma|Relapsed Ewing's Sarcoma of Bone|Relapsed Ewing's Sarcoma of the Bone|Relapsed Osseous Ewing's Sarcoma|Relapsed Skeletal Ewing's Sarcoma
C6623	Localized_Bone_Ewing_s_Sarcoma	Ewing_s_Sarcoma_of_Bone|Localized_Ewing_s_Sarcoma	Localized Bone Ewing's Sarcoma|Localized Ewing's Sarcoma of Bone|Localized Ewing's Sarcoma of the Bone|Localized Osseous Ewing's Sarcoma|Localized Skeletal Ewing's Sarcoma
C6624	Mediastinal_Neural_Neoplasm	Mediastinal_Neoplasm	Mediastinal Neural Neoplasm|Mediastinal Neural Tumor|Mediastinal Neurogenic Neoplasm|Mediastinal Neurogenic Tumor|Neurogenic Neoplasm of Mediastinum|Neurogenic Neoplasm of the Mediastinum|Neurogenic Tumor of Mediastinum|Neurogenic Tumor of the Mediastinum
C6625	Benign_Mediastinal_Schwannoma	Benign_Mediastinal_Neoplasm|Benign_Schwannoma|Mediastinal_Schwannoma	Benign Mediastinal Schwannoma|Benign Mediastinal Neurilemmoma|Benign Neurilemmoma of Mediastinum|Benign Neurilemmoma of the Mediastinum|Benign Schwannoma of Mediastinum|Benign Schwannoma of the Mediastinum
C6626	Mediastinal_Malignant_Peripheral_Nerve_Sheath_Tumor	Malignant_Mediastinal_Neoplasm|Malignant_Peripheral_Nerve_Sheath_Tumor	Mediastinal Malignant Peripheral Nerve Sheath Tumor|MPNST of Mediastinum|MPNST of the Mediastinum|Malignant Mediastinal Peripheral Nerve Sheath Neoplasm|Malignant Mediastinal Peripheral Nerve Sheath Tumor|Malignant Peripheral Nerve Sheath Neoplasm of Mediastinum|Malignant Peripheral Nerve Sheath Neoplasm of the Mediastinum|Malignant Peripheral Nerve Sheath Tumor of Mediastinum|Malignant Peripheral Nerve Sheath Tumor of the Mediastinum|Mediastinal MPNST
C6627	Mediastinal_Ganglioneuroblastoma	Malignant_Mediastinal_Neoplasm|Mediastinal_Neural_Neoplasm|Peripheral_Ganglioneuroblastoma	Mediastinal Ganglioneuroblastoma|Ganglioneuroblastoma of Mediastinum|Ganglioneuroblastoma of the Mediastinum
C6628	Mediastinal_Neuroblastoma	Malignant_Mediastinal_Neoplasm|Mediastinal_Neural_Neoplasm|Peripheral_Neuroblastoma	Mediastinal Neuroblastoma|Neuroblastoma of Mediastinum|Neuroblastoma of the Mediastinum
C6630	Malignant_Melanocytic_Peripheral_Nerve_Sheath_Tumor_of_the_Mediastinum	Malignant_Melanocytic_Peripheral_Nerve_Sheath_Tumor|Mediastinal_Malignant_Peripheral_Nerve_Sheath_Tumor	Malignant Melanocytic Peripheral Nerve Sheath Tumor of the Mediastinum|Malignant Mediastinal Melanocytic Peripheral Nerve Sheath Tumor|Malignant Melanocytic Peripheral Nerve Sheath Tumor of Mediastinum|Mediastinal Melanocytic MPNST
C6631	Mediastinal_Neurofibroma	Benign_Mediastinal_Neoplasm|Mediastinal_Neural_Neoplasm|Neurofibroma	Mediastinal Neurofibroma|Neurofibroma of Mediastinum|Neurofibroma of the Mediastinum
C6632	Mediastinal_Ganglioneuroma	Benign_Mediastinal_Neoplasm|Ganglioneuroma|Mediastinal_Neural_Neoplasm	Mediastinal Ganglioneuroma|Ganglioneuroma of Mediastinum|Ganglioneuroma of the Mediastinum
C6633	Mediastinal_Lymphoma	Lymphoma_by_Site|Malignant_Mediastinal_Neoplasm	Mediastinal Lymphoma|Lymphoma of Mediastinum|Lymphoma of the Mediastinum|Mediastinal Malignant Lymphoma|Primary Mediastinal Lymphoma
C6634	Mediastinal_Hodgkin_s_Lymphoma	Hodgkin_s_Lymphoma|Mediastinal_Lymphoma	Mediastinal Hodgkin's Lymphoma|Hodgkin's Disease of Mediastinum|Hodgkin's Disease of the Mediastinum|Hodgkin's Lymphoma of Mediastinum|Hodgkin's Lymphoma of the Mediastinum|Mediastinal Hodgkin's Disease|Mediastinal Hodgkins Disease|Mediastinal Hodgkins Lymphoma|Primary Mediastinal Hodgkin's Lymphoma
C6635	Mediastinal_Melanocytic_Schwannoma	Mediastinal_Schwannoma|Melanocytic_Schwannoma	Mediastinal Melanocytic Schwannoma|Mediastinal Melanocytic Neurilemmoma|Melanocytic Neurilemmoma of Mediastinum|Melanocytic Neurilemmoma of the Mediastinum|Melanocytic Schwannoma of Mediastinum|Melanocytic Schwannoma of the Mediastinum
C6636	Benign_Mediastinal_Psammomatous_Schwannoma	Benign_Mediastinal_Schwannoma	Benign Mediastinal Psammomatous Schwannoma|Benign Mediastinal Psammomatous Neurilemmoma|Benign Psammomatous Neurilemmoma of Mediastinum|Benign Psammomatous Neurilemmoma of the Mediastinum|Benign Psammomatous Schwannoma of Mediastinum|Benign Psammomatous Schwannoma of the Mediastinum
C6637	Mediastinal_Mesenchymal_Neoplasm	Mediastinal_Neoplasm|Soft_Tissue_Neoplasm	Mediastinal Mesenchymal Neoplasm|Mediastinal Mesenchymal Tumor|Mediastinal Soft Tissue Neoplasm|Mediastinal Soft Tissue Tumor|Mesenchymal Neoplasm of Mediastinum|Mesenchymal Neoplasm of the Mediastinum|Mesenchymal Tumor of Mediastinum|Mesenchymal Tumor of the Mediastinum|Soft Tissue Neoplasm of Mediastinum|Soft Tissue Neoplasm of the Mediastinum|Soft Tissue Tumor of Mediastinum|Soft Tissue Tumor of the Mediastinum
C6638	Stage_I_Neuroblastoma	Neuroblastoma	Stage I Neuroblastoma
C6639	Stage_II_Neuroblastoma	Neuroblastoma	Stage II Neuroblastoma
C6640	Stage_III_Neuroblastoma	Neuroblastoma	Stage III Neuroblastoma
C6641	Stage_IV_Neuroblastoma	Neuroblastoma	Stage IV Neuroblastoma|Disseminated Neuroblastoma|Metastatic Neuroblastoma
C6642	Malignant_Mediastinal_Mesenchymal_Neoplasm	Malignant_Mediastinal_Neoplasm|Malignant_Soft_Tissue_Neoplasm|Mediastinal_Mesenchymal_Neoplasm	Malignant Mediastinal Mesenchymal Neoplasm|Malignant Mediastinal Mesenchymal Tumor|Malignant Mediastinal Soft Tissue Neoplasm|Malignant Mediastinal Soft Tissue Tumor|Malignant Mesenchymal Neoplasm of Mediastinum|Malignant Mesenchymal Neoplasm of the Mediastinum|Malignant Mesenchymal Tumor of Mediastinum|Malignant Mesenchymal Tumor of the Mediastinum|Malignant Soft Tissue Neoplasm of Mediastinum|Malignant Soft Tissue Neoplasm of the Mediastinum|Malignant Soft Tissue Tumor of Mediastinum|Malignant Soft Tissue Tumor of the Mediastinum
C6643	Mediastinal_Schwannoma	Mediastinal_Neural_Neoplasm|Peripheral_Nerve_Schwannoma	Mediastinal Schwannoma|Mediastinal Neurilemmoma|Neurilemmoma of Mediastinum|Neurilemmoma of the Mediastinum|Schwannoma of Mediastinum|Schwannoma of the Mediastinum
C6644	Pleural_Lipoma	Benign_Pleural_Neoplasm|Lipoma	Pleural Lipoma|Lipoma of Pleura|Lipoma of the Pleura
C6645	Infantile_Hemangioendothelioma	Capillary_Hemangioma	Juvenile Hemangioma|Infantile Hemangioendothelioma|Infantile Hemangioma|Juvenile Capillary Hemangioma|Strawberry Nevus
C6646	Stage_I_Pleural_Mesothelioma	Malignant_Pleural_Mesothelioma	Stage I Pleural Mesothelioma|Stage I Mesothelioma of Pleura|Stage I Mesothelioma of the Pleura
C6647	Stage_II_Pleural_Mesothelioma	Malignant_Pleural_Mesothelioma	Stage II Pleural Mesothelioma|Stage II Mesothelioma of Pleura|Stage II Mesothelioma of the Pleura
C6648	Stage_III_Pleural_Mesothelioma	Malignant_Pleural_Mesothelioma	Stage III Pleural Mesothelioma|Stage III Mesothelioma of Pleura|Stage III Mesothelioma of the Pleura
C6649	Stage_IV_Pleural_Mesothelioma	Malignant_Pleural_Mesothelioma	Stage IV Pleural Mesothelioma|Stage IV Mesothelioma of Pleura|Stage IV Mesothelioma of the Pleura
C6650	Ampulla_of_Vater_Adenocarcinoma	Adenocarcinoma|Ampulla_of_Vater_Carcinoma	Ampulla of Vater Adenocarcinoma|Adenocarcinoma of Ampulla of Vater|Ampullary Adenocarcinoma
C6651	Stage_I_Ampulla_of_Vater_Cancer	Ampulla_of_Vater_Carcinoma	Stage I Ampulla of Vater Cancer|Ampulla of Vater Cancer Stage I|Stage I Ampulla of Vater Carcinoma|Stage I Ampullary Carcinoma
C6652	Stage_II_Ampulla_of_Vater_Cancer	Ampulla_of_Vater_Carcinoma	Stage II Ampulla of Vater Cancer|Ampulla of Vater Cancer Stage II|Stage II Ampulla of Vater Carcinoma|Stage II Ampullary Carcinoma
C6653	Stage_III_Ampulla_of_Vater_Cancer	Ampulla_of_Vater_Carcinoma	Stage III Ampulla of Vater Cancer|Ampulla of Vater Cancer Stage III|Stage III Ampulla of Vater Carcinoma|Stage III Ampullary Carcinoma
C6654	Stage_IV_Ampulla_of_Vater_Cancer	Ampulla_of_Vater_Carcinoma	Stage IV Ampulla of Vater Cancer|Ampulla of Vater Cancer Stage IV|Stage IV Ampulla of Vater Carcinoma|Stage IV Ampullary Carcinoma
C6655	Ampulla_of_Vater_Small_Cell_Carcinoma	Ampulla_of_Vater_Carcinoma|Small_Cell_Carcinoma	Ampulla of Vater Small Cell Carcinoma|Ampullary Small Cell Carcinoma
C6656	Ampulla_of_Vater_Signet_Ring_Cell_Carcinoma	Ampulla_of_Vater_Adenocarcinoma|Signet_Ring_Cell_Carcinoma	Ampulla of Vater Signet Ring Cell Carcinoma|Ampullary Signet Ring Cell Carcinoma
C6657	Ampulla_of_Vater_Adenoma	Adenomatous_Polyp|Ampulla_of_Vater_Neoplasm|Gastrointestinal_Adenoma	Ampulla of Vater Adenoma|Ampullary Adenoma
C6658	Ampulla_of_Vater_Villous_Adenoma	Ampulla_of_Vater_Adenoma|Villous_Adenoma	Ampulla of Vater Villous Adenoma|Ampullary Villous Adenoma
C6659	Ampulla_of_Vater_Tubular_Adenoma	Ampulla_of_Vater_Adenoma|Tubular_Adenoma	Ampulla of Vater Tubular Adenoma|Ampullary Tubular Adenoma
C6660	Stage_II_Large_Cell_Lung_Carcinoma	Large_Cell_Lung_Carcinoma|Stage_II_Non-Small_Cell_Lung_Cancer	Stage II Large Cell Lung Carcinoma|Stage II Large Cell Carcinoma of Lung|Stage II Large Cell Carcinoma of the Lung
C6661	Stage_IA_Large_Cell_Lung_Carcinoma	Stage_IA_Non-Small_Cell_Lung_Carcinoma|Stage_I_Large_Cell_Lung_Carcinoma	Stage IA Large Cell Lung Carcinoma|Stage IA Large Cell Carcinoma of Lung|Stage IA Large Cell Carcinoma of the Lung
C6662	Stage_IB_Large_Cell_Lung_Carcinoma	Stage_IB_Non-Small_Cell_Lung_Carcinoma|Stage_I_Large_Cell_Lung_Carcinoma	Stage IB Large Cell Lung Carcinoma|Stage IB Large Cell Carcinoma of Lung|Stage IB Large Cell Carcinoma of the Lung
C6663	Stage_IIB_Large_Cell_Lung_Carcinoma	Stage_IIB_Non-Small_Cell_Lung_Carcinoma|Stage_II_Large_Cell_Lung_Carcinoma	Stage IIB Large Cell Lung Carcinoma|Stage IIB Large Cell Carcinoma of Lung|Stage IIB Large Cell Carcinoma of the Lung
C6664	Stage_IIIB_Large_Cell_Lung_Carcinoma	Stage_IIIB_Non-Small_Cell_Lung_Cancer|Stage_III_Large_Cell_Lung_Carcinoma	Stage IIIB Large Cell Lung Carcinoma|Stage IIIB Large Cell Carcinoma of Lung|Stage IIIB Large Cell Carcinoma of the Lung
C6665	Stage_IIIA_Large_Cell_Lung_Carcinoma	Stage_IIIA_Non-Small_Cell_Lung_Cancer|Stage_III_Large_Cell_Lung_Carcinoma	Stage IIIA Large Cell Lung Carcinoma|Stage IIIA Large Cell Carcinoma of Lung|Stage IIIA Large Cell Carcinoma of the Lung
C6666	Stage_IIA_Large_Cell_Lung_Carcinoma	Stage_IIA_Non-Small_Cell_Lung_Carcinoma|Stage_II_Large_Cell_Lung_Carcinoma	Stage IIA Large Cell Lung Carcinoma|Stage IIA Large Cell Carcinoma of Lung|Stage IIA Large Cell Carcinoma of the Lung
C6667	Stage_IIA_Adenosquamous_Lung_Carcinoma	Stage_IIA_Non-Small_Cell_Lung_Carcinoma|Stage_II_Adenosquamous_Lung_Carcinoma	Stage IIA Adenosquamous Lung Carcinoma|Stage IIA Adenosquamous Cell Carcinoma of Lung|Stage IIA Adenosquamous Cell Carcinoma of the Lung|Stage IIA Adenosquamous Cell Lung Carcinoma
C6668	Stage_IA_Adenosquamous_Cell_Lung_Carcinoma	Stage_IA_Non-Small_Cell_Lung_Carcinoma|Stage_I_Adenosquamous_Lung_Carcinoma	Stage IA Adenosquamous Lung Carcinoma|Stage IA Adenosquamous Cell Carcinoma of Lung|Stage IA Adenosquamous Cell Carcinoma of the Lung|Stage IA Adenosquamous Cell Lung Carcinoma
C6669	Stage_IB_Adenosquamous_Cell_Lung_Carcinoma	Stage_IB_Non-Small_Cell_Lung_Carcinoma|Stage_I_Adenosquamous_Lung_Carcinoma	Stage IB Adenosquamous Lung Carcinoma|Stage IB Adenosquamous Cell Carcinoma of Lung|Stage IB Adenosquamous Cell Carcinoma of the Lung|Stage IB Adenosquamous Cell Lung Carcinoma
C6670	Stage_IIB_Adenosquamous_Lung_Carcinoma	Stage_IIB_Non-Small_Cell_Lung_Carcinoma|Stage_II_Adenosquamous_Lung_Carcinoma	Stage IIB Adenosquamous Lung Carcinoma|Stage IIB Adenosquamous Cell Carcinoma of Lung|Stage IIB Adenosquamous Cell Carcinoma of the Lung|Stage IIB Adenosquamous Cell Lung Carcinoma
C6671	Stage_I_Non-Small_Cell_Lung_Cancer	Non-Small_Cell_Lung_Carcinoma|Stage_I_Lung_Cancer	Stage I Non-Small Cell Lung Cancer|Stage I NSCLC|Stage I Non-Oat Cell Carcinoma of Lung|Stage I Non-Oat Cell Carcinoma of the Lung|Stage I Non-Oat Cell Lung Carcinoma|Stage I Non-Small Cell Carcinoma of Lung|Stage I Non-Small Cell Carcinoma of the Lung|Stage I Non-Small Cell Lung Carcinoma|stage I non-small cell lung cancer	Cancer in the lung only and not in tissue around the lung.
C6673	Stage_I_Small_Cell_Lung_Carcinoma	Limited_Stage_Small_Cell_Lung_Carcinoma|Stage_I_Lung_Cancer	Stage I Small Cell Lung Carcinoma|Stage I Small Cell Carcinoma of Lung|Stage I Small Cell Carcinoma of the Lung|Stage I Small Cell Lung Cancer
C6674	Stage_IA_Small_Cell_Lung_Carcinoma	Stage_IA_Lung_Carcinoma|Stage_I_Small_Cell_Lung_Carcinoma	Stage IA Small Cell Lung Carcinoma|Stage IA Small Cell Carcinoma of Lung|Stage IA Small Cell Carcinoma of the Lung|Stage IA Small Cell Lung Cancer
C6675	Stage_IB_Small_Cell_Lung_Carcinoma	Stage_IB_Lung_Carcinoma|Stage_I_Small_Cell_Lung_Carcinoma	Stage IB Small Cell Lung Carcinoma|Stage IB Small Cell Carcinoma of Lung|Stage IB Small Cell Carcinoma of the Lung|Stage IB Small Cell Lung Cancer
C6676	Stage_IIB_Small_Cell_Lung_Carcinoma	Stage_IIB_Lung_Carcinoma|Stage_II_Small_Cell_Lung_Carcinoma	Stage IIB Small Cell Lung Carcinoma|Stage IIB Small Cell Carcinoma of Lung|Stage IIB Small Cell Carcinoma of the Lung|Stage IIB Small Cell Lung Cancer
C6677	Stage_IIA_Small_Cell_Lung_Carcinoma	Stage_IIA_Lung_Carcinoma|Stage_II_Small_Cell_Lung_Carcinoma	Stage IIA Small Cell Lung Carcinoma|Stage IIA Small Cell Carcinoma of Lung|Stage IIA Small Cell Carcinoma of the Lung|Stage IIA Small Cell Lung Cancer
C6678	Stage_II_Small_Cell_Lung_Carcinoma	Limited_Stage_Small_Cell_Lung_Carcinoma|Stage_II_Lung_Cancer	Stage II Small Cell Lung Carcinoma|Stage II Small Cell Carcinoma of Lung|Stage II Small Cell Carcinoma of the Lung|Stage II Small Cell Lung Cancer
C6679	Stage_III_Small_Cell_Lung_Carcinoma	Small_Cell_Lung_Carcinoma|Stage_III_Lung_Cancer	Stage III Small Cell Lung Carcinoma|Stage III Small Cell Carcinoma of Lung|Stage III Small Cell Carcinoma of the Lung|Stage III Small Cell Lung Cancer
C6680	Stage_IIIA_Small_Cell_Lung_Carcinoma	Limited_Stage_Small_Cell_Lung_Carcinoma|Stage_IIIA_Lung_Carcinoma|Stage_III_Small_Cell_Lung_Carcinoma	Stage IIIA Small Cell Lung Carcinoma|Stage IIIA Small Cell Carcinoma of Lung|Stage IIIA Small Cell Carcinoma of the Lung|Stage IIIA Small Cell Lung Cancer
C6681	Stage_IIIB_Small_Cell_Lung_Carcinoma	Stage_IIIB_Lung_Carcinoma|Stage_III_Small_Cell_Lung_Carcinoma	Stage IIIB Small Cell Lung Carcinoma|Stage IIIB Small Cell Carcinoma of Lung|Stage IIIB Small Cell Carcinoma of the Lung|Stage IIIB Small Cell Lung Cancer
C6682	Stage_IV_Small_Cell_Lung_Carcinoma	Extensive_Stage_Small_Cell_Lung_Carcinoma|Stage_IV_Lung_Cancer	Stage IV Small Cell Lung Carcinoma|Stage IV Small Cell Carcinoma of Lung|Stage IV Small Cell Carcinoma of the Lung|Stage IV Small Cell Lung Cancer
C6683	Occult_Small_Cell_Lung_Carcinoma	Occult_Lung_Carcinoma|Small_Cell_Lung_Carcinoma	Occult Small Cell Lung Carcinoma|Occult Small Cell Carcinoma of Lung|Occult Small Cell Carcinoma of the Lung	A small cell lung carcinoma detectable by sputum cytology only.  The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed. (NCI05)
C6684	Occult_Adenosquamous_Lung_Carcinoma	Adenosquamous_Lung_Carcinoma|Occult_Non-Small_Cell_Lung_Carcinoma	Occult Adenosquamous Lung Carcinoma|Occult Adenosquamous Cell Carcinoma of Lung|Occult Adenosquamous Cell Carcinoma of the Lung|Occult Adenosquamous Cell Lung Carcinoma	An adenosquamous lung carcinoma detectable by sputum cytology only.  The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed. (NCI05)
C6685	Occult_Large_Cell_Lung_Carcinoma	Large_Cell_Lung_Carcinoma|Occult_Non-Small_Cell_Lung_Carcinoma	Occult Large Cell Lung Carcinoma|Occult Large Cell Carcinoma of Lung|Occult Large Cell Carcinoma of the Lung	A large cell lung carcinoma detectable by sputum cytology only.  The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed. (NCI05)
C6686	Occult_Squamous_Cell_Lung_Carcinoma	Squamous_Cell_Lung_Carcinoma	Occult Squamous Cell Lung Carcinoma|Occult Squamous Cell Carcinoma of Lung|Occult Squamous Cell Carcinoma of the Lung	A small cell lung carcinoma detectable by sputum cytology only.  The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed. (NCI05)
C6687	Stage_IA_Squamous_Cell_Lung_Carcinoma	Stage_I_Squamous_Cell_Lung_Carcinoma	Stage IA Squamous Cell Lung Carcinoma|Stage IA Squamous Cell Carcinoma of Lung|Stage IA Squamous Cell Carcinoma of the Lung
C6688	Stage_IIA_Squamous_Cell_Lung_Carcinoma	Stage_II_Squamous_Cell_Lung_Carcinoma	Stage IIA Squamous Cell Lung Carcinoma|Stage IIA Squamous Cell Carcinoma of Lung|Stage IIA Squamous Cell Carcinoma of the Lung
C6689	Stage_IIIA_Squamous_Cell_Lung_Carcinoma	Stage_III_Squamous_Cell_Lung_Carcinoma	Stage IIIA Squamous Cell Lung Carcinoma|Stage IIIA Squamous Cell Carcinoma of Lung|Stage IIIA Squamous Cell Carcinoma of the Lung
C6690	Stage_IIIB_Squamous_Cell_Lung_Carcinoma	Stage_III_Squamous_Cell_Lung_Carcinoma	Stage IIIB Squamous Cell Lung Carcinoma|Stage IIIB Squamous Cell Carcinoma of Lung|Stage IIIB Squamous Cell Carcinoma of the Lung
C6691	Stage_IIB_Squamous_Cell_Lung_Carcinoma	Stage_II_Squamous_Cell_Lung_Carcinoma	Stage IIB Squamous Cell Lung Carcinoma|Stage IIB Squamous Cell Carcinoma of Lung|Stage IIB Squamous Cell Carcinoma of the Lung
C6692	Stage_IB_Squamous_Cell_Lung_Carcinoma	Stage_I_Squamous_Cell_Lung_Carcinoma	Stage IB Squamous Cell Lung Carcinoma|Stage IB Squamous Cell Carcinoma of Lung|Stage IB Squamous Cell Carcinoma of the Lung
C6693	Stage_IB_Lung_Adenocarcinoma	Stage_IB_Non-Small_Cell_Lung_Carcinoma|Stage_I_Lung_Adenocarcinoma	Stage IB Lung Adenocarcinoma|Stage IB Adenocarcinoma of Lung|Stage IB Adenocarcinoma of the Lung
C6694	Stage_IA_Lung_Adenocarcinoma	Stage_IA_Non-Small_Cell_Lung_Carcinoma|Stage_I_Lung_Adenocarcinoma	Stage IA Lung Adenocarcinoma|Stage IA Adenocarcinoma of Lung|Stage IA Adenocarcinoma of the Lung
C6695	Stage_IIA_Lung_Adenocarcinoma	Stage_IIA_Non-Small_Cell_Lung_Carcinoma|Stage_II_Lung_Adenocarcinoma	Stage IIA Lung Adenocarcinoma|Stage IIA Adenocarcinoma of Lung|Stage IIA Adenocarcinoma of the Lung
C6696	Stage_IIB_Lung_Adenocarcinoma	Stage_IIB_Non-Small_Cell_Lung_Carcinoma|Stage_II_Lung_Adenocarcinoma	Stage IIB Lung Adenocarcinoma|Stage IIB Adenocarcinoma of Lung|Stage IIB Adenocarcinoma of the Lung
C6697	Stage_IIIB_Lung_Adenocarcinoma	Stage_IIIB_Non-Small_Cell_Lung_Cancer|Stage_III_Lung_Adenocarcinoma	Stage IIIB Lung Adenocarcinoma|Stage IIIB Adenocarcinoma of Lung|Stage IIIB Adenocarcinoma of the Lung
C6698	Stage_IIIA_Lung_Adenocarcinoma	Stage_IIIA_Non-Small_Cell_Lung_Cancer|Stage_III_Lung_Adenocarcinoma	Stage IIIA Lung Adenocarcinoma|Stage IIIA Adenocarcinoma of Lung|Stage IIIA Adenocarcinoma of the Lung
C6699	Occult_Lung_Adenocarcinoma	Lung_Adenocarcinoma|Occult_Non-Small_Cell_Lung_Carcinoma	Occult Lung Adenocarcinoma|Occult Adenocarcinoma of Lung|Occult Adenocarcinoma of the Lung	A lung adenocarcinoma detectable by sputum cytology only. The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed. (NCI05)
C6700	Pyriform_Fossa_Carcinoma	Hypopharyngeal_Carcinoma	Pyriform Fossa Carcinoma|Carcinoma of Pyriform Fossa|Carcinoma of Pyriform Sinus|Carcinoma of the Pyriform Fossa|Carcinoma of the Pyriform Sinus|Pyriform Sinus Carcinoma
C6701	Stage_IV_Osteosarcoma	Primary_Bone_Osteosarcoma|Stage_IV_Bone_Sarcoma	Stage IV Osteosarcoma|Stage IV Osteogenic Sarcoma
C6702	Stage_IVA_Osteosarcoma	Stage_IVA_Bone_Sarcoma|Stage_IV_Osteosarcoma	Stage IVA Osteosarcoma|Stage IVA Osteogenic Sarcoma
C6703	Stage_IVB_Osteosarcoma	Stage_IVB_Bone_Sarcoma|Stage_IV_Osteosarcoma	Stage IVB Osteosarcoma|Stage IVB Osteogenic Sarcoma
C6704	Stage_I_Bone_Sarcoma	Bone_Sarcoma	Stage I Bone Sarcoma|Stage I Sarcoma of Bone|Stage I Sarcoma of the Bone
C6705	Stage_II_Bone_Sarcoma	Bone_Sarcoma	Stage II Bone Sarcoma|Stage II Sarcoma of Bone|Stage II Sarcoma of the Bone
C6706	Stage_IV_Bone_Sarcoma	Bone_Sarcoma	Stage IV Bone Sarcoma|Stage IV Sarcoma of Bone|Stage IV Sarcoma of the Bone
C6707	Stage_IVA_Bone_Sarcoma	Stage_IV_Bone_Sarcoma	Stage IVA Bone Sarcoma|Stage IVA Sarcoma of Bone|Stage IVA Sarcoma of the Bone
C6708	Stage_IVB_Bone_Sarcoma	Stage_IV_Bone_Sarcoma	Stage IVB Bone Sarcoma|Stage IVB Sarcoma of Bone|Stage IVB Sarcoma of the Bone
C6709	Stage_I_Osteosarcoma	Primary_Bone_Osteosarcoma|Stage_I_Bone_Sarcoma	Stage I Osteosarcoma|Stage I Osteogenic Sarcoma
C6710	Stage_II_Osteosarcoma	Primary_Bone_Osteosarcoma|Stage_II_Bone_Sarcoma	Stage II Osteosarcoma|Stage II Osteogenic Sarcoma
C6711	Chest_Wall_Solitary_Plasmacytoma	Malignant_Chest_Wall_Neoplasm|Solitary_Plasmacytoma	Chest Wall Solitary Plasmacytoma|Solitary Plasmacytoma of Chest Wall|Solitary Plasmacytoma of the Chest Wall
C6712	Chest_Wall_Lymphoma	Lymphoma_by_Site|Malignant_Chest_Wall_Neoplasm	Chest Wall Lymphoma|Lymphoma of Chest Wall|Lymphoma of the Chest Wall|Primary Chest Wall Lymphoma
C6713	Chest_Wall_Fibromatosis	Benign_Chest_Wall_Neoplasm|Extraabdominal_Fibromatosis	Chest Wall Fibromatosis|Chest Wall Desmoid Neoplasm|Chest Wall Desmoid Tumor|Desmoid Neoplasm of Chest Wall|Desmoid Neoplasm of the Chest Wall|Desmoid Tumor of Chest Wall|Desmoid Tumor of the Chest Wall
C6714	Sternal_Chondromyxoid_Fibroma	Benign_Sternal_Neoplasm|Chondromyxoid_Fibroma	Sternal Chondromyxoid Fibroma|Chondromyxoid Fibroma of Sternum|Chondromyxoid Fibroma of the Sternum
C6716	Sternal_Lymphoma	Lymphoma_by_Site|Malignant_Sternal_Neoplasm	Sternal Lymphoma|Lymphoma of Sternum|Lymphoma of the Sternum|Primary Sternal Lymphoma
C6717	Sternal_Paget_s_Disease	Bone_Paget_s_Disease	Sternal Paget's Disease|Paget's Disease of Sternum|Paget's Disease of the Sternum
C6718	Sternal_Intraosseous_Schwannoma	Benign_Sternal_Neoplasm|Peripheral_Nerve_Schwannoma	Sternal Intraosseous Schwannoma|Intraosseous Neurilemmoma of Sternum|Intraosseous Neurilemmoma of the Sternum|Intraosseous Schwannoma of Sternum|Intraosseous Schwannoma of the Sternum|Sternal Intraosseous Neurilemmoma
C6719	Chest_Wall_Lipoma	Benign_Chest_Wall_Neoplasm|Lipoma	Chest Wall Lipoma|Lipoma of Chest Wall|Lipoma of the Chest Wall
C6720	Chest_Wall_Parachordoma	Benign_Chest_Wall_Neoplasm|Parachordoma	Chest Wall Parachordoma|Parachordoma of Chest Wall|Parachordoma of the Chest Wall
C6721	Chest_Wall_Plexiform_Fibrohistiocytic_Neoplasm	Chest_Wall_Neoplasm|Plexiform_Fibrohistiocytic_Tumor	Chest Wall Plexiform Fibrohistiocytic Neoplasm|Chest Wall Plexiform Fibrohistiocytic Tumor|Plexiform Fibrohistiocytic Neoplasm of Chest Wall|Plexiform Fibrohistiocytic Neoplasm of the Chest Wall|Plexiform Fibrohistiocytic Tumor of Chest Wall|Plexiform Fibrohistiocytic Tumor of the Chest Wall
C6722	Chest_Wall_Ectopic_Synovial_Bursa_Cyst	Chest_Wall_Cyst	Chest Wall Ectopic Synovial Bursa Cyst|Ectopic Synovial Bursa Cyst of the Chest Wall
C6723	Chest_Wall_Hodgkin_s_Lymphoma	Chest_Wall_Lymphoma|Hodgkin_s_Lymphoma	Chest Wall Hodgkin's Lymphoma|Chest Wall Hodgkin Lymphoma|Chest Wall Hodgkin's Disease|Chest Wall Hodgkins Disease|Chest Wall Hodgkins Lymphoma|Hodgkin's Disease of Chest Wall|Hodgkin's Disease of the Chest Wall|Hodgkin's Lymphoma of Chest Wall|Hodgkin's Lymphoma of the Chest Wall|Primary Chest Wall Hodgkin's Lymphoma
C6724	Malignant_Chest_Wall_Bone_Neoplasm	Malignant_Bone_Neoplasm|Malignant_Chest_Wall_Neoplasm	Malignant Chest Wall Bone Neoplasm|Malignant Bone Neoplasm of Chest Wall|Malignant Bone Neoplasm of the Chest Wall|Malignant Bone Tumor of Chest Wall|Malignant Bone Tumor of the Chest Wall|Malignant Chest Wall Bone Tumor
C6725	Hereditary_Non-Polyposis_Colon_Cancer_Type_1	Hereditary_Non-Polyposis_Colon_Cancer	Hereditary Non-Polyposis Colon Cancer Type 1|COCA 1|Familial Non-Polyposis Colon Cancer Type 1|HNPCC1|Lynch 1 Syndrome
C6726	Hereditary_Non-Polyposis_Colon_Cancer_Type_2	Hereditary_Non-Polyposis_Colon_Cancer	Hereditary Non-Polyposis Colon Cancer Type 2|COCA 2|Familial Non-Polyposis Colon Cancer Type 2|HNPCC2|Lynch 2 Syndrome
C6727	Neurofibromatosis	Hereditary_Neoplastic_Syndrome	Neurofibromatosis
C6728	Gardner_s_Syndrome	Hereditary_Neoplastic_Syndrome	Gardner's Syndrome	An autosomal dominant syndrome characterised by multiple colonic polyps predisposing to carcinoma of the colon, osteomas of the skull, epidermoid cysts, and fibromas.  It is associated with mutation of the APC gene. -- 2003
C6729	Flat_Adenoma_Syndrome	Hereditary_Neoplastic_Syndrome	Flat Adenoma Syndrome
C6730	Sternal_Neoplasm	Sternal_Disorder|Thoracic_Neoplasm	Sternal Neoplasm|Neoplasm of Sternum|Neoplasm of the Sternum|Sternal Tumor|Tumor of Sternum|Tumor of the Sternum
C6731	Stage_IIA_Esophageal_Adenocarcinoma	Stage_IIA_Esophageal_Cancer|Stage_II_Esophageal_Adenocarcinoma	Stage IIA Esophageal Adenocarcinoma|Stage IIA Adenocarcinoma of Esophagus|Stage IIA Adenocarcinoma of the Esophagus|Stage IIA Esophagus Adenocarcinoma
C6732	Stage_IIB_Esophageal_Adenocarcinoma	Stage_IIB_Esophageal_Cancer|Stage_II_Esophageal_Adenocarcinoma	Stage IIB Esophageal Adenocarcinoma|Stage IIB Adenocarcinoma of Esophagus|Stage IIB Adenocarcinoma of the Esophagus|Stage IIB Esophagus Adenocarcinoma
C6733	Stage_IVA_Esophageal_Adenocarcinoma	Stage_IVA_Esophageal_Cancer|Stage_IV_Esophageal_Adenocarcinoma	Stage IVA Esophageal Adenocarcinoma|Stage IVA Adenocarcinoma of Esophagus|Stage IVA Adenocarcinoma of the Esophagus|Stage IVA Esophagus Adenocarcinoma
C6734	Stage_IVB_Esophageal_Adenocarcinoma	Stage_IVB_Esophageal_Cancer|Stage_IV_Esophageal_Adenocarcinoma	Stage IVB Esophageal Adenocarcinoma|Stage IVB Adenocarcinoma of Esophagus|Stage IVB Adenocarcinoma of the Esophagus|Stage IVB Esophagus Adenocarcinoma
C6735	Stage_IVB_Esophageal_Squamous_Cell_Carcinoma	Stage_IVB_Esophageal_Cancer|Stage_IV_Esophageal_Squamous_Cell_Carcinoma	Stage IVB Esophageal Squamous Cell Carcinoma|Stage IVB Esophagus Squamous Cell Carcinoma|Stage IVB Squamous Cell Carcinoma of Esophagus|Stage IVB Squamous Cell Carcinoma of the Esophagus
C6736	Stage_IVA_Esophageal_Squamous_Cell_Carcinoma	Stage_IVA_Esophageal_Cancer|Stage_IV_Esophageal_Squamous_Cell_Carcinoma	Stage IVA Esophageal Squamous Cell Carcinoma|Stage IVA Esophagus Squamous Cell Carcinoma|Stage IVA Squamous Cell Carcinoma of Esophagus|Stage IVA Squamous Cell Carcinoma of the Esophagus
C6737	Stage_IIB_Esophageal_Squamous_Cell_Carcinoma	Stage_IIB_Esophageal_Cancer|Stage_II_Esophageal_Squamous_Cell_Carcinoma	Stage IIB Esophageal Squamous Cell Carcinoma|Stage IIB Esophagus Squamous Cell Carcinoma|Stage IIB Squamous Cell Carcinoma of Esophagus|Stage IIB Squamous Cell Carcinoma of the Esophagus
C6738	Stage_IIA_Esophageal_Squamous_Cell_Carcinoma	Stage_IIA_Esophageal_Cancer|Stage_II_Esophageal_Squamous_Cell_Carcinoma	Stage IIA Esophageal Squamous Cell Carcinoma|Stage IIA Esophagus Squamous Cell Carcinoma|Stage IIA Squamous Cell Carcinoma of Esophagus|Stage IIA Squamous Cell Carcinoma of the Esophagus
C6739	Cardiac_Rhabdomyoma	Benign_Myocardial_Neoplasm|Rhabdomyoma	Cardiac Rhabdomyoma|Heart Rhabdomyoma|Rhabdomyoma of Heart|Rhabdomyoma of the Heart	A small benign, probably hamartomatous, skeletal muscle lesion associated with tuberous sclerosis. -- 2003
C6740	Atrial_Septum_Lipomatous_Hypertrophy	Non-Neoplastic_Heart_Disorder	Atrial Septum Lipomatous Hypertrophy|Interatrial Septum Lipomatous Hypertrophy|Massive Fatty Deposits of Atrial Septum|Massive Fatty Deposits of the Atrial Septum
C6741	Cardiac_Lipoma	Benign_Cardiac_Neoplasm|Lipoma	Cardiac Lipoma|Lipoma of Heart|Lipoma of the Heart
C6742	Epicardial_Lipoma	Benign_Epicardial_Neoplasm|Cardiac_Lipoma	Epicardial Lipoma|Lipoma of Epicardium|Lipoma of the Epicardium
C6743	Pericardial_Leiomyoma	Benign_Pericardial_Neoplasm|Leiomyoma	Pericardial Leiomyoma|Leiomyoma of Pericardium|Leiomyoma of the Pericardium
C6744	Mature_Pericardial_Teratoma	Mature_Teratoma|Pericardial_Germ_Cell_Tumor	Mature Pericardial Teratoma|Benign Pericardial Teratoma|Mature Teratoma of Pericardium|Mature Teratoma of the Pericardium
C6745	Superior_Vena_Cava_Leiomyosarcoma	Malignant_Superior_Vena_Cava_Neoplasm|Vascular_Leiomyosarcoma	Superior Vena Cava Leiomyosarcoma|Leiomyosarcoma of Superior Vena Cava|Leiomyosarcoma of the Superior Vena Cava
C6746	Pulmonary_Artery_Angiosarcoma	Angiosarcoma	Pulmonary Artery Angiosarcoma|Pulmonary Artery Hemangiosarcoma
C6747	Malignant_Fibrous_Mesothelioma	Diffuse_Malignant_Mesothelioma	Desmoplastic Mesothelioma
C6748	Benign_Glomus_Tumor	Benign_Perivascular_Neoplasm|Glomus_Tumor	Benign Glomus Tumor|Benign Glomus Neoplasm
C6749	Palate_Kaposi_s_Sarcoma	Kaposi_s_Sarcoma|Malignant_Palate_Neoplasm	Palate Kaposi's Sarcoma|Kaposi's Sarcoma of Palate|Kaposi's Sarcoma of the Palate
C6750	Cutaneous_Glomangioma	Benign_Dermal_Neoplasm|Glomangioma	Cutaneous Glomangioma|Glomangioma of Skin|Glomangioma of the Skin|Skin Glomangioma
C6751	Benign_Extragonadal_Germ_Cell_Neoplasm	Benign_Germ_Cell_Neoplasm|Extragonadal_Germ_Cell_Neoplasm	Benign Extragonadal Germ Cell Tumor|Benign Extragonadal Germ Cell Neoplasm
C6752	Pineal_Region_Yolk_Sac_Tumor	Malignant_Pineal_Region_Germ_Cell_Neoplasm|Yolk_Sac_Tumor	Pineal Region Yolk Sac Tumor|Endodermal Sinus Tumor of Pineal Region|Endodermal Sinus Tumor of the Pineal Region|Pineal Endodermal Sinus Neoplasm|Pineal Endodermal Sinus Tumor|Pineal Region Endodermal Sinus Neoplasm|Pineal Region Endodermal Sinus Tumor|Pineal Region Yolk Sac Neoplasm|Yolk Sac Tumor of Pineal Region|Yolk Sac Tumor of the Pineal Region
C6753	Pineal_Region_Teratoma	Central_Nervous_System_Teratoma|Pineal_Region_Germ_Cell_Tumor	Pineal Region Teratoma|Pineal Area Teratoma|Teratoma of Pineal Area|Teratoma of Pineal Region|Teratoma of the Pineal Area|Teratoma of the Pineal Region
C6754	Pineal_Region_Mature_Teratoma	Mature_Teratoma|Pineal_Region_Teratoma	Pineal Region Mature Teratoma|Mature Teratoma of Pineal Area|Mature Teratoma of Pineal Region|Mature Teratoma of the Pineal Area|Mature Teratoma of the Pineal Region|Pineal Area Mature Teratoma
C6755	Pineal_Region_Immature_Teratoma	Immature_Extragonadal_Teratoma|Malignant_Pineal_Region_Germ_Cell_Neoplasm|Pineal_Region_Teratoma	Pineal Region Immature Teratoma|Atypical Pineal Teratoma|Immature Teratoma of Pineal Area|Immature Teratoma of Pineal Region|Immature Teratoma of the Pineal Area|Immature Teratoma of the Pineal Region|Pineal Area Immature Teratoma
C6756	Pineal_Region_Meningioma	Intracranial_Meningioma|Pineal_Region_Neoplasm	Pineal Region Meningioma|Meningioma of Pineal Area|Meningioma of Pineal Gland|Meningioma of Pineal Region|Meningioma of the Pineal Area|Meningioma of the Pineal Gland|Meningioma of the Pineal Region|Pineal Area Meningioma|Pineal Gland Meningioma|Pineal Meningioma
C6757	Benign_Central_Nervous_System_Soft_Tissue_Neoplasm	Central_Nervous_System_Soft_Tissue_Neoplasm	Benign Central Nervous System Soft Tissue Neoplasm|Benign CNS Soft Tissue Neoplasm|Benign CNS Soft Tissue Tumor|Benign Central Nervous System Soft Tissue Tumor|Benign Soft Tissue Neoplasm of CNS|Benign Soft Tissue Neoplasm of Central Nervous System|Benign Soft Tissue Neoplasm of the CNS|Benign Soft Tissue Neoplasm of the Central Nervous System|Benign Soft Tissue Tumor of CNS|Benign Soft Tissue Tumor of Central Nervous System|Benign Soft Tissue Tumor of the CNS|Benign Soft Tissue Tumor of the Central Nervous System
C6758	Malignant_Central_Nervous_System_Soft_Tissue_Neoplasm	Central_Nervous_System_Soft_Tissue_Neoplasm|Malignant_Central_Nervous_System_Neoplasm|Malignant_Soft_Tissue_Neoplasm|Mesenchymal_Non-Meningothelial_Tumor_of_the_Central_Nervous_System	Malignant Central Nervous System Soft Tissue Neoplasm|Malignant CNS Soft Tissue Neoplasm|Malignant CNS Soft Tissue Tumor|Malignant Central Nervous System Soft Tissue Tumor|Malignant Soft Tissue Neoplasm of CNS|Malignant Soft Tissue Neoplasm of Central Nervous System|Malignant Soft Tissue Neoplasm of the CNS|Malignant Soft Tissue Neoplasm of the Central Nervous System|Malignant Soft Tissue Tumor of CNS|Malignant Soft Tissue Tumor of Central Nervous System|Malignant Soft Tissue Tumor of the CNS|Malignant Soft Tissue Tumor of the Central Nervous System|Soft Tissue Cancer of Central Nervous System|Soft Tissue Cancer of the Central Nervous System
C6759	Pineal_Region_Choriocarcinoma	Choriocarcinoma|Malignant_Pineal_Region_Germ_Cell_Neoplasm	Pineal Region Choriocarcinoma|Choriocarcinoma of Pineal Area|Choriocarcinoma of Pineal Region|Choriocarcinoma of the Pineal Area|Choriocarcinoma of the Pineal Region|Pineal Area Choriocarcinoma|Pineal Choriocarcinoma
C6760	Breast_Small_Cell_Carcinoma	Breast_Neuroendocrine_Neoplasm|Invasive_Breast_Carcinoma|Small_Cell_Carcinoma	Breast Small Cell Carcinoma|Breast Oat Cell Carcinoma|Mammary Small Cell Carcinoma|Oat Cell Carcinoma of Breast|Oat Cell Carcinoma of the Breast|Small Cell Carcinoma of Breast|Small Cell Carcinoma of the Breast|Small Cell Neuroendocrine Carcinoma of Breast|Small Cell Neuroendocrine Carcinoma of the Breast
C6761	Colon_Small_Cell_Carcinoma	Colon_Carcinoma|Colon_Neuroendocrine_Neoplasm|Colorectal_Small_Cell_Carcinoma	Colon Small Cell Carcinoma|Colon Oat Cell Carcinoma|Colonic Oat Cell Carcinoma|Colonic Small Cell Carcinoma|Oat Cell Carcinoma of Colon|Oat Cell Carcinoma of the Colon|Oat Cell Colon Carcinoma|Small Cell Carcinoma of Colon|Small Cell Carcinoma of the Colon|Small Cell Colon Carcinoma
C6762	Esophageal_Small_Cell_Carcinoma	Esophageal_Carcinoma|Esophageal_Neuroendocrine_Neoplasm|Small_Cell_Carcinoma	Esophageal Small Cell Carcinoma|Esophageal Oat Cell Carcinoma|Esophagus Oat Cell Carcinoma|Esophagus Small Cell Carcinoma|Oat Cell Carcinoma of Esophagus|Oat Cell Carcinoma of the Esophagus|Small Cell Carcinoma of Esophagus|Small Cell Carcinoma of the Esophagus|Small Cell Carcinoma, Esophagus	A neuroendocrine carcinoma that occurs mainly in the sixth to seventh decade; it is as common in males as females.  It usually involves the distal half of the esophagus, and dysphagia is the presenting symptom.  The prognosis is poor.  (WHO, 2000) -- 2003
C6763	Gallbladder_Small_Cell_Carcinoma	Gallbladder_Carcinoma|Small_Cell_Carcinoma	Gallbladder Small Cell Carcinoma|Gallbladder Oat Cell Carcinoma|Oat Cell Carcinoma of Gallbladder|Oat Cell Carcinoma of the Gallbladder|Small Cell Carcinoma of Gallbladder|Small Cell Carcinoma of the Gallbladder
C6764	Gastric_Small_Cell_Carcinoma	Gastric_Carcinoma|Gastric_Neuroendocrine_Neoplasm|Small_Cell_Carcinoma	Gastric Small Cell Carcinoma|Gastric Oat Cell Carcinoma|Oat Cell Carcinoma of Stomach|Oat Cell Carcinoma of the Stomach|Small Cell Carcinoma of Stomach|Small Cell Carcinoma of the Stomach	A malignant neuroendocrine neoplasm with aggressive clinical course, morphologically identical to the small cell carcinoma of the lung. (WHO, 2000) -- 2003
C6766	Prostate_Small_Cell_Carcinoma	Prostate_Carcinoma|Prostate_Neuroendocrine_Neoplasm|Small_Cell_Carcinoma	Prostate Small Cell Carcinoma|Oat Cell Carcinoma of Prostate|Oat Cell Carcinoma of the Prostate|Prostate Oat Cell Carcinoma|Small Cell Carcinoma of Prostate|Small Cell Carcinoma of the Prostate
C6767	Malignant_Pineal_Region_Germ_Cell_Neoplasm	Malignant_Intracranial_Germ_Cell_Neoplasm|Malignant_Pineal_Region_Neoplasm|Pineal_Region_Germ_Cell_Tumor	Malignant Pineal Region Germ Cell Tumor|Malignant Germ Cell Neoplasm of Pineal Gland|Malignant Germ Cell Neoplasm of Pineal Parenchyma|Malignant Germ Cell Neoplasm of the Pineal Gland|Malignant Germ Cell Neoplasm of the Pineal Parenchyma|Malignant Germ Cell Tumor of Pineal Gland|Malignant Germ Cell Tumor of Pineal Parenchyma|Malignant Germ Cell Tumor of the Pineal Gland|Malignant Germ Cell Tumor of the Pineal Parenchyma|Malignant Pineal Area Germ Cell Neoplasm|Malignant Pineal Area Germ Cell Tumor|Malignant Pineal Gland Germ Cell Neoplasm|Malignant Pineal Gland Germ Cell Tumor|Malignant Pineal Parenchymal Germ Cell Neoplasm|Malignant Pineal Parenchymal Germ Cell Tumor|Malignant Pineal Region Germ Cell Neoplasm|Pineal Germ Cell Neoplasm, Malignant	Malignant germ cell tumor within the pineal parenchyma.  This can include mixed germ cell, germinomas, teratomas, choriocarcinomas, embryonal cell carcinoma and endodermal sinus histological types.  These tumors occur more frequently in males, children and young adults.  The presenting symptoms can include hypothalamic-pituitary abnormalities with diabetes insipidus as the most common.  Malignant germ cell tumors have been noted to metastasize both within and outside the neuraxis.  One should obtain measurements of serum and CSF AFP and beta-HCG for use in diagnosis and monitoring.  A change in the levels of these tumor markers can act as a sentinel for tumor recurrence.
C6768	Depression_and_Suicide	Conceptual_Entities	Depression and Suicide|suicide and depression
C6769	Optic_Nerve_Astrocytoma	Optic_Nerve_Glioma|Visual_Pathway_Astrocytoma	Optic Nerve Astrocytoma|Astrocytic Neoplasm of Optic Nerve|Astrocytic Neoplasm of the Optic Nerve|Astrocytic Tumor of Optic Nerve|Astrocytic Tumor of the Optic Nerve|Astrocytoma of Optic Nerve|Astrocytoma of the Optic Nerve|Optic Nerve Astrocytic Neoplasm|Optic Nerve Astrocytic Tumor
C6770	Ependymal_Tumor	Central_Nervous_System_Neoplasm|Neuroglial_Tumor	Ependymal Tumor|Ependymal Neoplasm|Ependymal Neoplasms|Ependymal Tumors|ependymal tumors	A type of brain tumor that usually begins in the central canal of the spinal cord. Ependymal tumors may also develop in the cells lining the ventricles of the brain, which produce and store the special fluid (cerebrospinal fluid) that protects the brain and spinal cord. Also called ependymomas.
C6771	Olfactory_Groove_Meningioma	Anterior_Cranial_Fossa_Meningioma	Olfactory Groove Meningioma|Meningioma of Olfactory Groove|Meningioma of the Olfactory Groove
C6772	Childhood_Supratentorial_Ependymoblastoma	Childhood_Supratentorial_Neoplasm|Ependymoblastoma	Childhood Supratentorial Ependymoblastoma|Pediatric Supratentorial Ependymoblastoma
C6773	Childhood_Infratentorial_Ependymoblastoma	Childhood_Infratentorial_Neoplasm|Ependymoblastoma	Childhood Infratentorial Ependymoblastoma|Pediatric Infratentorial Ependymoblastoma
C6774	Recurrent_Childhood_Medulloblastoma	Childhood_Medulloblastoma|Recurrent_Childhood_Brain_Neoplasm	Recurrent Childhood Medulloblastoma|Recurrent Pediatric Medulloblastoma|Relapsed Childhood Medulloblastoma|Relapsed Pediatric Medulloblastoma
C6775	Posterior_Cranial_Fossa_Meningioma	Intracranial_Meningioma	Posterior Cranial Fossa Meningioma|Meningioma of Posterior Cranial Fossa|Meningioma of the Posterior Cranial Fossa
C6776	Suprasellar_Meningioma	Supratentorial_Meningioma	Suprasellar Meningioma
C6777	Periocular_Meningioma	Intraorbital_Meningioma	Periocular Meningioma
C6778	Intraorbital_Meningioma	Meningioma_by_Site|Orbit_Neoplasm	Intraorbital Meningioma
C6779	Gasserian_Meningioma	Supratentorial_Meningioma	Gasserian Meningioma|Gasserian Ganglion Meningioma|Meningioma of Gasserian Ganglion|Meningioma of the Gasserian Ganglion
C6780	Acidophil_Adenoma	Pituitary_Gland_Neoplasm_Antiquated	Pituitary Gland Acidophil Adenoma|Acidophil Adenoma|Eosinophil Adenoma
C6781	Stromal_Neoplasm	Soft_Tissue_Neoplasm	Stromal Neoplasm|Stromal Tumor|stromal tumors	(STRO-mal) Tumors that arise in the supporting connective tissue of an organ.
C6782	Mesonephroma	Mesonephric_Neoplasm	Mesonephroma|Wolffian Duct Neoplasm|Wolffian Duct Tumor
C6783	Transitional_Cell_Neoplasm	Epithelial_Neoplasm	Transitional Cell Neoplasm|Transitional Cell Tumor
C6784	Cystic_Neoplasm	Neoplasm_by_Special_Category	Cystic Neoplasm|Cystic Tumor
C6786	Malignant_Eyelid_Neoplasm	Eyelid_Neoplasm	Malignant Eyelid Neoplasm|Malignant Eyelid Tumor|Malignant Neoplasm of Eyelid|Malignant Neoplasm of the Eyelid|Malignant Tumor of Eyelid|Malignant Tumor of the Eyelid
C6790	Ectopic_Parathormone_Secretion	Ectopic_Hormone_Secretion_Syndromes_Associated_with_Neoplasia	Ectopic Parathormone Secretion	Abnormal secretion of parathyroid hormone in conjunction with neoplastic growth occurring anywhere in the body.
C6791	Parotid_Gland_Carcinoma	Major_Salivary_Gland_Carcinoma|Malignant_Parotid_Gland_Neoplasm	Parotid Gland Carcinoma|Carcinoma of Parotid|Carcinoma of Parotid Gland|Carcinoma of the Parotid|Carcinoma of the Parotid Gland|Parotid Carcinoma
C6792	Sphenoid_Sinus_Neoplasm	Paranasal_Sinus_Neoplasm	Sphenoid Sinus Neoplasm|Neoplasm of Sphenoid Sinus|Neoplasm of Sphenoidal Sinus|Neoplasm of the Sphenoid Sinus|Neoplasm of the Sphenoidal Sinus|Sphenoid Sinus Tumor|Sphenoidal Sinus Neoplasm|Sphenoidal Sinus Tumor|Tumor of Sphenoid Sinus|Tumor of Sphenoidal Sinus|Tumor of the Sphenoid Sinus|Tumor of the Sphenoidal Sinus
C6793	Supraglottis_Neoplasm	Laryngeal_Neoplasm	Supraglottis Neoplasm|Neoplasm of Supraglottis|Neoplasm of the Supraglottis|Supraglottic Neoplasm|Supraglottic Tumor|Supraglottis Tumor|Tumor of Supraglottis|Tumor of the Supraglottis
C6794	Gastric_Cardia_Carcinoma	Gastric_Carcinoma	Gastric Cardia Carcinoma|Cancer of Gastric Cardia|Cancer of the Gastric Cardia|Carcinoma of Cardia of Stomach|Carcinoma of Gastric Cardia|Carcinoma of the Cardia of the Stomach|Carcinoma of the Gastric Cardia|Gastric Cardia Cancer
C6795	Gastric_Pylorus_Carcinoma	Gastric_Carcinoma	Gastric Pylorus Carcinoma|Cancer of Gastric Pylorus|Cancer of Pylorus of Stomach|Cancer of the Gastric Pylorus|Cancer of the Pylorus of the Stomach|Carcinoma of Gastric Pylorus|Carcinoma of Pylorus of Stomach|Carcinoma of the Gastric Pylorus|Carcinoma of the Pylorus of the Stomach|Gastric Pylorus Cancer
C6796	Eccrine_Neoplasm	Sweat_Gland_Neoplasm	Eccrine Neoplasm|Eccrine Neoplasm of Skin|Eccrine Neoplasm of the Skin|Eccrine Skin Neoplasm|Eccrine Skin Tumor|Eccrine Tumor|Eccrine Tumor of Skin|Eccrine Tumor of the Skin
C6797	Benign_Eccrine_Neoplasm	Benign_Sweat_Gland_Neoplasm|Eccrine_Neoplasm	Benign Eccrine Neoplasm|Benign Eccrine Neoplasm of Skin|Benign Eccrine Neoplasm of the Skin|Benign Eccrine Skin Neoplasm|Benign Eccrine Skin Tumor|Benign Eccrine Tumor|Benign Eccrine Tumor of Skin|Benign Eccrine Tumor of the Skin
C6798	Apocrine_Neoplasm	Sweat_Gland_Neoplasm	Apocrine Neoplasm|Apocrine Neoplasm of Skin|Apocrine Neoplasm of the Skin|Apocrine Skin Neoplasm|Apocrine Skin Tumor|Apocrine Tumor|Apocrine Tumor of Skin|Apocrine Tumor of the Skin
C6799	Benign_Apocrine_Neoplasm	Apocrine_Neoplasm|Benign_Sweat_Gland_Neoplasm	Benign Apocrine Neoplasm|Benign Apocrine Neoplasm of Skin|Benign Apocrine Neoplasm of the Skin|Benign Apocrine Skin Neoplasm|Benign Apocrine Skin Tumor|Benign Apocrine Tumor|Benign Apocrine Tumor of Skin|Benign Apocrine Tumor of the Skin
C6800	Malignant_Apocrine_Neoplasm	Apocrine_Neoplasm|Malignant_Sweat_Gland_Neoplasm	Malignant Apocrine Neoplasm|Malignant Apocrine Neoplasm of Skin|Malignant Apocrine Neoplasm of the Skin|Malignant Apocrine Skin Neoplasm|Malignant Apocrine Skin Tumor|Malignant Apocrine Tumor|Malignant Apocrine Tumor of Skin|Malignant Apocrine Tumor of the Skin
C6801	Cutaneous_Fibrous_Histiocytoma	Benign_Cutaneous_Fibrohistiocytic_Neoplasm|Benign_Fibrous_Histiocytoma	Cutaneous Fibrous Histiocytoma|Benign Cutaneous Fibrous Histiocytoma|Benign Fibrous Cutaneous Histiocytoma|Benign Fibrous Histiocytoma of Skin|Benign Fibrous Histiocytoma of the Skin|Benign Skin Fibrous Histiocytoma|Dermatofibroma|Fibrous Histiocytoma of Skin|Fibrous Histiocytoma of the Skin	Also known as dermatofibroma, this is a solitary, slowly growing nodular mass, most often affecting the extremities.  It is composed of fibrous and histiocytic cells which infiltrate the dermis and occasionally the underlying subcutaneous tissue.  Usually local excision is curative.  Recurrences are reported only in a small minority of cases. -- 2003
C6803	Benign_Ovarian_Sex_Cord-Stromal_Tumor	Benign_Ovarian_Neoplasm|Ovarian_Sex_Cord-Stromal_Tumor	Benign Ovarian Sex Cord-Stromal Tumor|Benign Ovarian Sex Cord-Stromal Neoplasm|Benign Sex Cord-Stromal Neoplasm of Ovary|Benign Sex Cord-Stromal Neoplasm of the Ovary|Benign Sex Cord-Stromal Tumor of Ovary|Benign Sex Cord-Stromal Tumor of the Ovary
C6804	Lacrimal_Gland_Carcinoma_Ex_Pleomorphic_Adenoma	Carcinoma_Ex_Pleomorphic_Adenoma|Lacrimal_Gland_Carcinoma|Lacrimal_Gland_Malignant_Mixed_Tumor	Lacrimal Gland Carcinoma ex Pleomorphic Adenoma|Carcinoma ex Pleomorphic Adenoma of Lacrimal Gland|Carcinoma ex Pleomorphic Adenoma of the Lacrimal Gland
C6805	Metastasis_to_Pituitary_Gland	Malignant_Pituitary_Gland_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Pituitary Gland|Metastasis to Pituitary Gland|Metastatic Neoplasm to the Pituitary Gland	A malignant neoplasm metastasizing to the pituitary gland from another anatomic site.  The vast majority are carcinomas usually arising from the breast, lung, and gastrointestinal tract. (NCI05)
C6806	Benign_Cutaneous_Fibrous_Neoplasm	Benign_Dermal_Neoplasm|Benign_Fibrous_Soft_Tissue_Neoplasm|Cutaneous_Fibrous_Tissue_Neoplasm	Benign Cutaneous Fibrous Neoplasm|Benign Cutaneous Fibrous Tissue Neoplasm|Benign Fibrous Tissue Neoplasm of Skin|Benign Fibrous Tissue Skin Neoplasm|Benign Fibrous Tissue Skin Tumor|Benign Fibrous Tissue Tumor of Skin
C6807	Benign_External_Ear_Neoplasm	Benign_Ear_Neoplasm|External_Ear_Neoplasm	Benign External Ear Neoplasm|Benign External Ear Tumor|Benign Neoplasm of External Ear|Benign Neoplasm of the External Ear|Benign Tumor of External Ear|Benign Tumor of the External Ear
C6808	Dermoid_Cyst_of_the_Spinal_Cord	Central_Nervous_System_Dermoid_Cyst	Dermoid Cyst of the Spinal Cord|Dermoid Cyst of Spinal Cord|Spinal Cord Dermoid|Spinal Cord Dermoid Cyst
C6809	Cerebellar_Pilocytic_Astrocytoma	Benign_Cerebellar_Neoplasm|Cerebellar_Astrocytoma|Pilocytic_Astrocytoma	Cerebellar Pilocytic Astrocytoma|Pilocytic Astrocytoma of Cerebellum|Pilocytic Astrocytoma of the Cerebellum	A WHO Grade 1 astrocytoma which arises in the cerebellum.  The tumor is composed of spindle shaped cells with numerous collections of reddish astrocytic fibers called Rosenthal fibers. Over 80% or the cerebellar astrocytomas of childhood are pilocytic. Pilocytic astrocytomas may rarely occur in adults. They are usually treated by surgical resection and in most cases have a favorable prognosis.  (KEV 8-7-99)
C6810	Testicular_Lymphoma	Lymphoma_by_Site|Malignant_Testicular_Neoplasm	Testicular Lymphoma|Lymphoma of Testis|Lymphoma of the Testis|Primary Testicular Lymphoma
C6811	Plantar_Verrucous_Skin_Carcinoma	Skin_Squamous_Cell_Carcinoma|Verrucous_Carcinoma	Plantar Verrucous Skin Carcinoma|Plantar Verrucous Carcinoma of Skin|Plantar Verrucous Carcinoma of the Skin
C6812	Mediastinal_Seminoma	Extragonadal_Seminoma|Malignant_Mediastinal_Germ_Cell_Neoplasm	Mediastinal Seminoma|Seminoma of Mediastinum|Seminoma of the Mediastinum
C6813	Prostate_Ductal_Adenocarcinoma	Prostate_Adenocarcinoma	Prostate Ductal Adenocarcinoma|Ductal Adenocarcinoma of Prostate|Ductal Adenocarcinoma of the Prostate|Endometrioid Adenocarcinoma of Prostate|Endometrioid Adenocarcinoma of the Prostate|Endometrioid Carcinoma of Prostate|Endometrioid Carcinoma of the Prostate|Prostate Endometrioid Adenocarcinoma|Prostate Endometrioid Carcinoma|Prostatic Endometrioid Carcinoma
C6814	Superficial_Fibromatosis	Fibromatosis	Superficial Fibromatosis
C6815	Spinal_Cord_Hamartoma	Central_Nervous_System_Hamartoma	Spinal Cord Hamartoma|Hamartoma of Spinal Cord|Hamartoma of the Spinal Cord
C6816	Low-Grade_B-Cell_Non-Hodgkin_s_Lymphoma	Low-Grade_Lymphoma	Low Grade B-Cell Non-Hodgkin's Lymphoma
C6817	High-Grade_B-Cell_Non-Hodgkin_s_Lymphoma	High-Grade_Lymphoma	High Grade B-Cell Non-Hodgkin's Lymphoma
C6819	Intermediate-Grade_B-Cell_Non-Hodgkin_s_Lymphoma	Intermediate-Grade_Lymphoma	Intermediate Grade B-Cell Non-Hodgkin's Lymphoma
C6820	Grade_I_Pancreatic_Intraepithelial_Neoplasia	Low_Grade_Glandular_Intraepithelial_Neoplasia|Pancreatic_Intraepithelial_Neoplasia	Grade I Pancreatic Intraepithelial Neoplasia|Grade 1 Pancreatic Intraepithelial Neoplasia
C6822	Balanced_Chromosomal_Alteration	Chromosomal_Translocation	Balanced Chromosomal Translocation|Balanced Chromosomal Aberration/Rearrangement|Balanced Chromosomal Alteration|Balanced Chromosomal Rearrangement	Interchanges of genetic material among different chromosomes following the breaking off of pieces of chromosomes such that the total chromosome composition may still contain all of the genetic material.Balanced Chromosomal Rearrangement.
C6823	Unbalanced_Chromosomal_Alteration	Chromosomal_Translocation	Unbalanced Translocation|Unbalanced Chromosomal Alteration|Unbalanced Chromosomal Alteration/Rearrangement|Unbalanced Chromosomal Rearrangement	Interchanges of genetic material among different chromosomes following the breaking off of pieces of chromosomes such that the total chromosome composition does not contain all of the genetic material.
C6824	Reciprocal_Chromosomal_Translocations	Retired_Concepts	Reciprocal Chromosomal Translocations
C6825	Numerical_Chromosome_Aberration	Chromosomal_Aberration	Numerical Chromosomal Abnormality|Numerical Chromosomal Abnormalities|Numerical Chromosome Aberration|Numerical Chromosome Anomalies|Numerical Chromosome Anomaly	An irregularity in the number of chromosomes.
C6826	Structural_Chromosomal_Abnormality	Chromosomal_Aberration	Structural Chromosomal Abnormality|Structural Chromosome Aberration|Structural Chromosome Anomalies
C6827	Chromosomal_Inversion	Structural_Chromosomal_Abnormality	Chromosomal Inversion|inv
C6828	Chromosomal_Insertion	Structural_Chromosomal_Abnormality	Chromosomal Insertion|ins
C6829	Chromosomal_Duplication	Chromosomal_Gain	Chromosomal Duplication|Chromosomal Amplification|dup	An irregularity in the number of chromosomes, usually in the form of a gain of genetic material. (NCI)
C6830	Derivative_Chromosome	Chromosomal_Aberration	Derivative Chromosome|der
C6831	Isodicentric_Chromosome	Chromosomal_Aberration	Isodicentric Chromosome|idic
C6832	Homogeneously_Staining_Region	Chromosomal_Aberration	Homogeneously Staining Region|hsr	A region on a chromosome which, when stained, is uniform in appearance. (Normally, a stained chromosome shows a banding pattern.) Homogeneously staining regions contain multiple copies of a single gene.  (Online Medical Dictionary)
C6833	Double_Minutes	Chromosomal_Aberration	Double Minutes|DM
C6834	Middle_Ear_Adenoma	Adenoma|Benign_Middle_Ear_Neoplasm	Middle Ear Adenoma|Adenoma of Middle Ear|Adenoma of the Middle Ear
C6835	Paranasal_Sinus_Schneiderian_Papilloma	Benign_Paranasal_Sinus_Neoplasm|Schneiderian_Papilloma	Paranasal Sinus Schneiderian Papilloma|Accessory Sinus Schneiderian Papilloma|Schneiderian Papilloma of Accessory Sinus|Schneiderian Papilloma of Paranasal Sinus|Schneiderian Papilloma of the Accessory Sinus|Schneiderian Papilloma of the Paranasal Sinus
C6836	Ethmoid_Sinus_Schneiderian_Papilloma	Benign_Ethmoid_Sinus_Neoplasm|Paranasal_Sinus_Schneiderian_Papilloma	Ethmoid Sinus Schneiderian Papilloma|Schneiderian Papilloma of Ethmoid Sinus|Schneiderian Papilloma of the Ethmoid Sinus
C6837	Frontal_Sinus_Schneiderian_Papilloma	Benign_Frontal_Sinus_Neoplasm|Paranasal_Sinus_Schneiderian_Papilloma	Frontal Sinus Schneiderian Papilloma|Schneiderian Papilloma of Frontal Sinus|Schneiderian Papilloma of the Frontal Sinus
C6838	Sphenoid_Sinus_Schneiderian_Papilloma	Benign_Sphenoid_Sinus_Neoplasm|Paranasal_Sinus_Schneiderian_Papilloma	Sphenoid Sinus Schneiderian Papilloma|Schneiderian Papilloma of Sphenoid Sinus|Schneiderian Papilloma of the Sphenoid Sinus
C6839	Maxillary_Sinus_Schneiderian_Papilloma	Benign_Maxillary_Sinus_Neoplasm|Paranasal_Sinus_Schneiderian_Papilloma	Maxillary Sinus Schneiderian Papilloma|Schneiderian Papilloma of Maxillary Sinus|Schneiderian Papilloma of the Maxillary Sinus
C6840	Maxillary_Sinus_Inverted_Papilloma	Benign_Maxillary_Sinus_Neoplasm|Paranasal_Sinus_Inverted_Papilloma	Maxillary Sinus Inverted Papilloma|Inverted Papilloma of Maxillary Sinus|Inverted Papilloma of the Maxillary Sinus
C6841	Sphenoid_Sinus_Inverted_Papilloma	Benign_Sphenoid_Sinus_Neoplasm|Paranasal_Sinus_Inverted_Papilloma	Sphenoid Sinus Inverted Papilloma|Inverted Papilloma of Sphenoid Sinus|Inverted Papilloma of the Sphenoid Sinus
C6842	Frontal_Sinus_Inverted_Papilloma	Benign_Frontal_Sinus_Neoplasm|Paranasal_Sinus_Inverted_Papilloma	Frontal Sinus Inverted Papilloma|Inverted Papilloma of Frontal Sinus|Inverted Papilloma of the Frontal Sinus
C6843	Ethmoid_Sinus_Inverted_Papilloma	Benign_Ethmoid_Sinus_Neoplasm|Paranasal_Sinus_Inverted_Papilloma	Ethmoid Sinus Inverted Papilloma|Inverted Papilloma of Ethmoid Sinus|Inverted Papilloma of the Ethmoid Sinus
C6844	Hard_Palate_Monomorphic_Adenoma	Benign_Hard_Palate_Neoplasm|Oral_Cavity_Monomorphic_Adenoma	Hard Palate Monomorphic Adenoma|Monomorphic Adenoma of Hard Palate|Monomorphic Adenoma of the Hard Palate
C6845	Oral_Cavity_Monomorphic_Adenoma	Oral_Cavity_Adenoma	Oral Cavity Monomorphic Adenoma|Monomorphic Adenoma of Oral Cavity|Monomorphic Adenoma of the Oral Cavity
C6846	Thyroid_Hyalinizing_Trabecular_Adenoma	Thyroid_Neoplasm	Thyroid Gland Hyalinizing Trabecular Tumor|Hyalinizing Trabecular Adenoma of Thyroid|Hyalinizing Trabecular Adenoma of the Thyroid|Hyalinizing Trabecular Tumor|PLAT|Paraganglioma-like Adenoma|Thyroid Hyalinizing Trabecular Adenoma	A rare, circumscribed or encapsulated tumor arising from the follicular cells of the thyroid gland.  It is characterized by a trabecular growth pattern and hyalinized stroma formation.  The vast majority of cases have a benign clinical course. (NCI05)
C6847	Parotid_Gland_Monomorphic_Adenoma	Benign_Parotid_Gland_Neoplasm|Salivary_Gland_Monomorphic_Adenoma	Parotid Gland Monomorphic Adenoma|Monomorphic Adenoma of Parotid|Monomorphic Adenoma of Parotid Gland|Monomorphic Adenoma of the Parotid|Monomorphic Adenoma of the Parotid Gland|Parotid Monomorphic Adenoma
C6848	Middle_Ear_Adenocarcinoma	Adenocarcinoma|Middle_Ear_Carcinoma	Middle Ear Adenocarcinoma|Adenocarcinoma of Middle Ear|Adenocarcinoma of the Middle Ear
C6849	Paranasal_Sinus_Sarcoma	Malignant_Paranasal_Sinus_Neoplasm|Soft_Tissue_Sarcoma	Paranasal Sinus Sarcoma|Accessory Sinus Sarcoma|Sarcoma of Accessory Sinus|Sarcoma of Paranasal Sinus|Sarcoma of the Accessory Sinus|Sarcoma of the Paranasal Sinus
C6850	High_Grade_Paranasal_Sinus_Sarcoma	Paranasal_Sinus_Sarcoma	High Grade Paranasal Sinus Sarcoma|High Grade Accessory Sinus Sarcoma|High Grade Sarcoma of Accessory Sinus|High Grade Sarcoma of Paranasal Sinus|High Grade Sarcoma of the Accessory Sinus|High Grade Sarcoma of the Paranasal Sinus
C6851	Low_Grade_Paranasal_Sinus_Sarcoma	Paranasal_Sinus_Sarcoma	Low Grade Paranasal Sinus Sarcoma|Low Grade Accessory Sinus Sarcoma|Low Grade Sarcoma of Accessory Sinus|Low Grade Sarcoma of Paranasal Sinus|Low Grade Sarcoma of the Accessory Sinus|Low Grade Sarcoma of the Paranasal Sinus
C6852	Adult_Atypical_Meningioma	Adult_Meningioma|Atypical_Meningioma	Adult Atypical Meningioma
C6853	Kadish_Stage_A_Olfactory_Neuroblastoma	Olfactory_Neuroblastoma	Kadish Stage A Olfactory Neuroblastoma
C6854	Kadish_Stage_B_Olfactory_Neuroblastoma	Olfactory_Neuroblastoma	Kadish Stage B Olfactory Neuroblastoma
C6856	Cervical_Microglandular_Polyp	Endocervical_Polyp	Cervical Microglandular Polyp|Microglandular Polyp of Cervix|Microglandular Polyp of Uterine Cervix|Microglandular Polyp of the Cervix|Microglandular Polyp of the Uterine Cervix|Uterine Cervix Microglandular Polyp
C6857	Vulvar_Fibroepithelial_Polyp	Fibroepithelial_Polyp|Vulvar_Polyp	Vulvar Fibroepithelial Polyp|Fibroepithelial Polyp of Vulva|Fibroepithelial Polyp of the Vulva|Vulva Fibroepithelial Polyp|Vulval Fibroepithelial Polyp|Vulvar Fibroepithelial Stromal Polyp
C6858	Cutaneous_B-Cell_Lymphoma	Cutaneous_Lymphoma|Cutaneous_Mature_B-Cell_Neoplasm|Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Cutaneous B-Cell Non-Hodgkin's Lymphoma|B Cell Non-Hodgkin's Lymphoma of Skin|B Cell Non-Hodgkin's Lymphoma of the Skin|CBCL|Primary Cutaneous B-Cell Non-Hodgkin's Lymphoma
C6859	Grade_3_Cutaneous_Follicular_Lymphoma	Cutaneous_Follicular_Lymphoma|Grade_3_Follicular_Lymphoma	Grade 3 Cutaneous Follicular Lymphoma|Cutaneous Large B Cell Follicular Lymphoma|Large B Cell Follicular Lymphoma of Skin|Large B Cell Follicular Lymphoma of the Skin
C6860	Primary_Cutaneous_Anaplastic_Large_Cell_Lymphoma	Anaplastic_Large_Cell_Lymphoma|Cutaneous_T-Cell_Lymphoma|Indolent_Non-Hodgkin_s_Lymphoma|Primary_Cutaneous_CD30-Positive_T-Cell_Lymphoproliferative_Disorder	Primary Cutaneous Anaplastic Large Cell Lymphoma|Primary Anaplastic Large Cell Lymphoma of Skin|Primary Anaplastic Large Cell Lymphoma of the Skin|Primary Cutaneous CD30 Positive Anaplastic Large Cell Lymphoma|Primary Cutaneous CD30+ ALCL|Primary Cutaneous CD30+ Anaplastic Large Cell Lymphoma	An anaplastic large cell lymphoma limited to the skin at the time of diagnosis.  Most patients present with solitary or localized skin lesions, which may be tumors, nodules or papules.  The t(2;5) translocation that is present in many cases of systemic anaplastic large cell lymphoma, is not found in this disease. (WHO, 2001) -- 2003
C6861	Choroid_Spindle_Cell_Type_A_Melanoma	Choroid_Spindle_Cell_Melanoma|Spindle_Cell_Type_A_Uveal_Melanoma	Choroid Spindle Cell Type A Melanoma|Spindle Cell Type A Melanoma of Choroid|Spindle Cell Type A Melanoma of the Choroid
C6862	Choroid_Spindle_Cell_Type_B_Melanoma	Choroid_Spindle_Cell_Melanoma|Spindle_Cell_Type_B_Uveal_Melanoma	Choroid Spindle Cell Type B Melanoma|Spindle Cell Type B Melanoma of Choroid|Spindle Cell Type B Melanoma of the Choroid
C6863	Ciliary_Body_Spindle_Cell_Type_B_Melanoma	Ciliary_Body_Spindle_Cell_Melanoma|Spindle_Cell_Type_B_Uveal_Melanoma	Ciliary Body Spindle Cell Type B Melanoma|Spindle Cell Type B Melanoma of Ciliary Body|Spindle Cell Type B Melanoma of the Ciliary Body
C6864	Ciliary_Body_Spindle_Cell_Type_A_Melanoma	Ciliary_Body_Spindle_Cell_Melanoma|Spindle_Cell_Type_A_Uveal_Melanoma	Ciliary Body Spindle Cell Type A Melanoma|Spindle Cell Type A Melanoma of Ciliary Body|Spindle Cell Type A Melanoma of the Ciliary Body
C6865	Choroid_Necrotic_Melanoma	Choroid_Melanoma|Necrotic_Uveal_Melanoma	Choroid Necrotic Melanoma|Necrotic Choroid Melanoma|Necrotic Melanoma of Choroid|Necrotic Melanoma of the Choroid
C6867	Myelodysplastic_Syndrome_Associated_with_Isolated_del_5q_Chromosome_Abnormality	Myelodysplastic_Syndrome	Myelodysplastic Syndrome Associated with Isolated del (5q) Chromosome Abnormality|5q- Syndrome	5Q minus syndrome.  A rare disorder caused by loss of part of the long arm (Q arm) of human chromosome 5. This syndrome affects myeloid (bone marrow) cells, causing treatment-resistant anemia, and myelodysplastic syndromes that may lead to acute myelogenous leukemia.
C6868	Stage_IV_Laryngeal_Cancer	Laryngeal_Carcinoma	Stage IV Laryngeal Cancer|Laryngeal Cancer, Stage IV|Metastatic Carcinoma of Larynx|Metastatic Carcinoma of the Larynx|Metastatic Laryngeal Carcinoma|Metastatic Larynx Carcinoma|Stage IV Carcinoma of Larynx|Stage IV Carcinoma of the Larynx|Stage IV Laryngeal Carcinoma|Stage IV Larynx Carcinoma|stage IV laryngeal cancer	The cancer has spread to tissues around the larynx, such as the pharynx or the tissues in the neck. The lymph nodes in the area may contain cancer; the cancer has spread to more than one lymph node on the same side of the neck as the cancer, to lymph nodes on one or both sides of the neck, or to any lymph node that measures more than 6 centimeters (over 2 inches); or the cancer has spread to other parts of the body.
C6869	Cystic_Hypersecretory_Breast_Carcinoma	Secretory_Breast_Carcinoma	Cystic Hypersecretory Breast Carcinoma|Cystic Hypersecretory Carcinoma of Breast|Cystic Hypersecretory Carcinoma of the Breast|Cystic Hypersecretory Duct Breast Carcinoma|Cystic Hypersecretory Duct Carcinoma of Breast|Cystic Hypersecretory Duct Carcinoma of the Breast
C6870	Solid_Papillary_Carcinoma_of_the_Breast	Invasive_Papillary_Breast_Carcinoma	Solid Papillary Breast Carcinoma|Solid Papillary Carcinoma of the Breast	A malignant breast neoplasm characterized by the formation of irregular, finger-like projections of fibrous stroma covered with neoplastic epithelial cells.
C6871	Inverted_Schneiderian_Papilloma	Inverted_Transitional_Cell_Papilloma|Schneiderian_Papilloma	Inverted Schneiderian Papilloma	Schneiderian papilloma most associated with malignancy.  Classically found on the lateral nasal wall with extension into the adjacent sinuses. (from J La State Med Soc 1997;149:310-5)
C6873	Stage_IV_Anal_Canal_Cancer	Anal_Canal_Carcinoma	Stage IV Anal Canal Cancer|Anal Cancer Stage IV|Stage IV Anal Cancer|Stage IV Anal Carcinoma|Stage IV Carcinoma of Anus|Stage IV Carcinoma of the Anus|stage IV anal cancer	Cancer has spread to distant lymph nodes within the abdomen or to organs in other parts of the body.
C6874	Clear_Cell_Neoplasm	Retired_Concepts	Clear Cell Neoplasm|Clear Cell Tumor
C6875	Large_Cell_Neuroendocrine_Carcinoma	Neuroendocrine_Carcinoma	Large Cell Neuroendocrine Carcinoma|Large-cell neuroendocrine carcinoma
C6876	Large_Cell_Lung_Carcinoma_with_Rhabdoid_Phenotype	Large_Cell_Lung_Carcinoma	Large Cell Lung Carcinoma with Rhabdoid Phenotype|Large Cell Carcinoma with Rhabdoid Phenotype	A rare poorly differentiated morphologic variant of large cell lung carcinoma characterized by the presence of rhabdoid cells. (NCI05)
C6877	Grade_III_Glandular_Intraepithelial_Neoplasia	Carcinoma_in_situ|Grade_III_Intraepithelial_Neoplasia|High_Grade_Glandular_Intraepithelial_Neoplasia	Grade III Glandular Intraepithelial Neoplasia
C6878	Mixed_Acinar-Endocrine_Carcinoma	Mixed_Exocrine-Endocrine_Carcinoma|Pancreatic_Acinar_Cell_Carcinoma	Mixed Acinar-Endocrine Carcinoma
C6879	Mixed_Ductal-Endocrine_Carcinoma	Mixed_Exocrine-Endocrine_Carcinoma|Pancreatic_Ductal_Adenocarcinoma	Mixed Ductal-Endocrine Carcinoma
C6880	Glandular_Papilloma	Papilloma	Glandular Papilloma
C6881	Bile_Duct_Papillomatosis	Bile_Duct_Neoplasm|Papillomatosis	Bile Duct Papillomatosis|Biliary Papillomatosis
C6882	Micropapillary_Serous_Carcinoma	Adenocarcinoma|Serous_Neoplasm	Micropapillary Serous Carcinoma
C6883	Pancreatic_Mucinous_Cystic_Neoplasm_with_Moderate_Dysplasia	Borderline_Exocrine_Pancreatic_Neoplasm|Pancreatic_Mucinous_Cystic_Neoplasm	Pancreatic Borderline Mucinous Cystic Neoplasm|Mucinous Cystic Neoplasm of Pancreas with Moderate Dysplasia|Mucinous Cystic Neoplasm of the Pancreas with Moderate Dysplasia|Mucinous Cystic Tumor of Pancreas with Moderate Dysplasia|Mucinous Cystic Tumor of the Pancreas with Moderate Dysplasia|Mucinous Cystic Tumor with Moderate Dysplasia|Pancreatic Low Grade Malignant Mucinous Cystic Neoplasm|Pancreatic Mucinous Cystic Neoplasm with Moderate Dysplasia|Pancreatic Mucinous Cystic Tumor with Moderate Dysplasia
C6884	Acinar_Cell_Cystadenocarcinoma	Retired_Concepts	Acinar Cell Cystadenocarcinoma
C6885	Thymoma_Type_AB	Thymoma	Thymoma Type AB|Mixed Type Thymoma
C6886	Malignant_Type_AB_Thymoma	Malignant_Thymoma|Thymoma_Type_AB	Malignant Type AB Thymoma
C6887	Thymoma_Type_B1	Thymoma_Type_B	Thymoma Type B1|Lymphocyte-Predominant Thymoma|Lymphocyte-Rich Thymoma|Organoid Thymoma|Predominantly Cortical Thymoma
C6888	Thymoma_Type_B2	Thymoma_Type_B	Thymoma Type B2|Cortical Thymoma|Polygonal Cell Thymoma
C6889	Malignant_Type_B2_Thymoma	Malignant_Thymoma|Thymoma_Type_B2	Malignant Type B2 Thymoma
C6890	Diffuse_Melanocytosis	Primary_Melanocytic_Lesion_of_Meninges	Diffuse Melanocytosis|Diffuse Melanosis|Diffuse Meningeal Melanocytosis	Diffuse Melanocytosis is a diffuse or multifocal proliferation of uniform nevoid polygonal cells in the leptomeninges. Cells may spread into the Virchow-Robin spaces without frank invasion of the brain. Diffuse Melanocytosis carries a poor prognosis even in the absence of histologic malignancy. (WHO)
C6891	Meningeal_Melanomatosis	Melanomatosis|Primary_Melanocytic_Lesion_of_Meninges	Meningeal Melanomatosis|Leptomeningeal Melanomatosis	Meningeal Melanomatosis is a Malignant Meningeal Melanoma with secondary diffuse meningeal spread. (WHO)
C6892	Cellular_Fibroma	Fibroma	Cellular Fibroma
C6893	Solitary_Fibrous_Tumor_of_the_Pleura_and_Peritoneum	Retired_Concepts	Pleural Solitary Fibrous Tumor|Localized Fibrous Mesothelioma of Pleura|Localized Fibrous Mesothelioma of the Pleura|Pleural Submesothelial Fibroma|Solitary Fibrous Tumor of Pleura|Solitary Fibrous Tumor of the Pleura
C6894	Malignant_Solitary_Fibrous_Tumor	Neoplasm_by_Obsolete_Classification	Malignant Solitary Fibrous Tumor
C6895	Atypical_Polypoid_Adenomyoma	Adenomyoma	Atypical Polypoid Adenomyoma
C6896	Benign_Cystic_Nephroma	Benign_Renal_Neoplasm|Cystic_Nephroma	Benign Cystic Nephroma
C6897	Cystic_Partially_Differentiated_Nephroblastoma	Renal_Wilms_Tumor	Cystic Partially Differentiated Nephroblastoma
C6898	Malignant_Multilocular_Cystic_Nephroma	Malignant_Cystic_Nephroma	Malignant Multilocular Cystic Nephroma
C6899	Adenomyoepithelioma	Breast_Myoepithelial_Neoplasm|Mixed_Neoplasm	Breast Adenomyoepithelioma|Adenomyoepithelioma of the Breast
C6900	Epithelioid_Trophoblastic_Tumor	Gestational_Trophoblastic_Tumor	Epithelioid Trophoblastic Tumor
C6901	Central_Osteosarcoma	Primary_Bone_Osteosarcoma	Central Osteosarcoma|Medullary Osteosarcoma
C6902	Chondroid_Chordoma	Chordoma	Chondroid Chordoma
C6903	Tanycytic_Ependymoma	Ependymoma	Tanycytic Ependymoma	Tanycytic Ependymoma is a variant of Ependymoma, often found in the spinal cord, with tumor cells arranged in fascicles of variable width and cell density. Ependymal rosettes are generally absent, so this lesion must be distinguished from astrocytic neoplasms, but its EM characteristics are ependymal. (Adapted from WHO.)
C6904	Large_Cell_Medulloblastoma	Medulloblastoma	Large Cell Medulloblastoma	Large Cell Medulloblastoma is a variant of Medulloblastoma (about 4% of cases). Some features of the tumor cells are large, round and/or pleomorphic nuclei with prominent nucleoli and a more abundant cytoplasm than that found in the classic medulloblastoma. (Adapted from WHO.)
C6905	Cerebellar_Liponeurocytoma	Cerebellar_Neuronal_and_Mixed_Neuronal-Glial_Tumor	Cerebellar Liponeurocytoma|Lipomatous Medulloblastoma	Cerebellar Liponeurocytoma (WHO grade I or II) is a rare cerebellar neoplasm which shows advanced neuronal/neurocytic and focal lipomatous differentiation. It occurs in adults, has a low proliferative potential and has a favorable clinical prognosis. (Adapted from WHO)
C6906	Atypical_Teratoid_Rhabdoid_Tumor	Embryonal_Neoplasm_of_the_CNS|Extrarenal_Rhabdoid_Tumor|Malignant_Brain_Neoplasm|Malignant_Childhood_Central_Nervous_System_Neoplasm	Atypical Teratoid/Rhabdoid Tumor|AT/RT|CNS Rhabdoid Neoplasm|CNS Rhabdoid Tumor|Central Nervous System Rhabdoid Neoplasm|Central Nervous System Rhabdoid Tumor|Malignant Brain Rhabdoid Neoplasm|Malignant Brain Rhabdoid Tumor|Malignant Rhabdoid Neoplasm of Brain|Malignant Rhabdoid Neoplasm of the Brain|Malignant Rhabdoid Tumor of Brain|Malignant Rhabdoid Tumor of the Brain|Primary Malignant Brain Rhabdoid Neoplasm|Primary Malignant Brain Rhabdoid Tumor|Primary Malignant Rhabdoid Neoplasm of Brain|Primary Malignant Rhabdoid Neoplasm of the Brain|Primary Malignant Rhabdoid Tumor of Brain|Primary Malignant Rhabdoid Tumor of the Brain|Rhabdoid Neoplasm of CNS|Rhabdoid Neoplasm of Central Nervous System|Rhabdoid Neoplasm of the CNS|Rhabdoid Neoplasm of the Central Nervous System|Rhabdoid Tumor of CNS|Rhabdoid Tumor of Central Nervous System|Rhabdoid Tumor of the CNS|Rhabdoid Tumor of the Central Nervous System	Atypical teratoid/rhabdoid tumor (WHO grade IV) is a malignant embryonal CNS tumor which occurs in children and is composed of rhabdoid cells, with or without fields resembling a classical primitive neuroectodermal tumor (PNET), epithelial tissue and neoplastic mesenchyme. (Adapted from WHO.)
C6907	Metaplastic_Meningioma	Grade_I_Meningioma	Metaplastic Meningioma	A WHO grade I meningioma with striking focal mesenchymal differentiation. (Adapted from WHO 2000.) - 2004
C6908	Chordoid_Meningioma	Grade_II_Meningioma	Chordoid Meningioma	A WHO grade II meningioma with regions that are histologically similar to chordoma, with trabecula of eosinophilic, vacuolated cells in a myxoid background. Chordoid meningiomas have a high rate of recurrence following subtotal resection. (Adapted from WHO 2000.) - 2004
C6909	Rhabdoid_Meningioma	Grade_III_Meningioma	Rhabdoid Meningioma	An uncommon WHO grade III meningioma containing patches or extensive sheets of rhabdoid cells. Rhabdoid cells are rounded tumor cells with eccentric nuclei, often with a prominent nucleolus and prominent inclusion-like eosinophilic cytoplasm comprised of whorled intermediate filaments. Rhabdoid Meningiomas typically display an aggressive clinical course. (Adapted from WHO 2000.) - 2004
C6910	Melanotic_Psammomatous_Malignant_Peripheral_Nerve_Sheath_Tumor	Malignant_Melanocytic_Peripheral_Nerve_Sheath_Tumor	Melanocytic Psammomatous Malignant Peripheral Nerve Sheath Tumor|Melanocytic Psammomatous MPNST
C6911	Intraneural_Perineurioma	Perineurioma|Peripheral_Nervous_System_Neoplasm	Intraneural Perineurioma	Intraneural Perineuriomas (WHO grade I) are rare, benign tumors that exhibit proliferating perineural cells throughout the endoneurium, with formation of characteristic pseudo-onion bulbs. (Adapted from WHO.)
C6912	Soft_Tissue_Perineurioma	Perineurioma	Soft Tissue Perineurioma	Soft Tissue Perineuriomas (WHO grade I) are rare, benign tumors composed entirely of neoplastic perineurial cells and are unassociated with nerves. (Adapted from WHO.)
C6913	Lymphocyte_Rich_Classical_Hodgkin_s_Lymphoma	Classical_Hodgkin_s_Lymphoma	Lymphocyte Rich Classical Hodgkin's Lymphoma|LRCHL|Lymphocyte Rich Classical Hodgkin Lymphoma|Lymphocyte Rich Classical Hodgkin's Disease|Lymphocyte Rich Hodgkin Lymphoma|Lymphocyte Rich Hodgkin's Disease|Lymphocyte Rich Hodgkin's Lymphoma|Lymphocyte-Rich Classical Hodgkin Lymphoma|Lymphocyte-Rich Classical Hodgkin's Lymphoma	A subtype of classical Hodgkin's lymphoma.  Most patients present with peripheral lymphadenopathy and limited stage disease (stage I or II).  The survival and progression free survival are slightly better than in other subtypes of classical Hodgkin's lymphoma. (WHO, 2001) -- 2003
C6914	Hodgkin_s_Granuloma	Hodgkin_s_Lymphoma_Antiquated	Hodgkin's Granuloma
C6915	Primary_Effusion_Lymphoma	Human_Herpes_Virus_8-Related_Malignant_Neoplasm|Mature_B-Cell_Non-Hodgkin_s_Lymphoma|Virus-Related_Lymphoma	Primary Effusion Lymphoma|Body Cavity-Based Lymphoma|PEL	An aggressive non-Hodgkin's B-cell lymphoma composed of large cells, presenting as a serous effusion without detectable tumor masses.  It is universally associated with human herpes virus 8 (HHV-8)/Kaposi sarcoma herpes virus (KSHV) [HHV-8/KSHV].  It mostly occurs in the setting of immunodeficiency; most cases have been reported in HIV positive patients.  The most common sites of involvement are the pleural, pericardial, and peritoneal cavities.  The prognosis is extremely unfavorable. -- 2004
C6916	Anaplastic_Lymphoma	Diffuse_Large_B-Cell_Lymphoma	Anaplastic Lymphoma|Anaplastic Large B-Cell Lymphoma
C6917	Atypical_Burkitt_s_Burkitt_s-Like_Lymphoma	Burkitt_s_Lymphoma	Atypical Burkitt's/Burkitt's-Like Lymphoma|Atypical Burkitt/Burkitt-like Lymphoma|Burkitt's-like Lymphoma|Burkitt-like Lymphoma
C6918	Subcutaneous_Panniculitis-Like_T-Cell_Lymphoma	Cutaneous_T-Cell_Lymphoma|Indolent_Non-Hodgkin_s_Lymphoma	Subcutaneous Panniculitis-Like T-Cell Lymphoma|SPTCL|Subcutaneous Panniculitis-Like T-Cell Lymphoma (Alpha/Beta Type)|Subcutaneous Panniculitis-Like T-Cell Lymphoma, Alpha/Beta Type	A cytotoxic primary cutaneous T-cell lymphoma.  Recent studies suggest there are at least two groups of subcutaneous panniculitis-like T-cell lymphomas, each with distinct histologic features, immunophenotypic profile, and prognosis.  One group has an alpha/beta, CD8 positive phenotype, involves only subcutaneous tissues, and usually has an indolent clinical course.  The second group has a gamma/delta phenotype, is CD8 negative, often co-expresses CD56, is not confined to the subcutaneous tissues, and usually has a poor prognosis.  In the recent WHO-EORTC classification, the term subcutaneous panniculitis-like T-cell lymphoma is reserved for cases with an alpha/beta, CD8 positive phenotype.  Cases with a gamma/delta phenotype are included in the group of cutaneous gamma/delta T-cell lymphomas.
C6919	Precursor_T_Lymphoblastic_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|Precursor_Lymphoblastic_Lymphoma|Precursor_T_Lymphoblastic_Leukemia_Lymphoma|T-Cell_Non-Hodgkin_s_Lymphoma	Precursor T-Lymphoblastic Lymphoma|Precursor T Lymphoblastic Lymphoma|Precursor T-Cell Lymphoblastic Lymphoma	The most frequent type of lymphoblastic lymphoma and comprises approximately 85-90% of cases.  It is more frequently seen in adolescent males.  (WHO, 2001) -- 2003
C6920	Hand-Schuller-Christian_Disease	Langerhans_Cell_Histiocytosis	Hand-Schuller-Christian Disease
C6921	Langerhans_Cell_Sarcoma	Histiocytic_and_Dendritic_Cell_Neoplasms	Langerhans Cell Sarcoma	A neoplastic proliferation of Langerhans cells with overtly malignant cytologic features.  It can be considered a higher grade variant of Langerhans cell histiocytosis (LCH) and it can present de novo or progress from antecedent LCH. (WHO, 2001) -- 2003
C6923	Acute_Bilineal_Leukemia	Acute_Leukemia_of_Ambiguous_Lineage	Acute Bilineal Leukemia	An acute leukemia of ambiguous lineage in which there is a dual population of blasts with each population expressing markers of a distinct lineage (myeloid and lymphoid or B-and T-lymphocyte).  (WHO, 2001) -- 2003
C6924	Acute_Myeloid_Leukemia_with_11q23_MLL_Abnormalities	Acute_Myeloid_Leukemia_with_Recurrent_Genetic_Abnormalities	Acute Myeloid Leukemia with 11q23 (MLL) Abnormalities|Acute Myeloid Leukemia with 11q23 Abnormalities|Acute Myeloid Leukemia, MLL	An acute myeloid leukemia (AML) usually associated with monocytic features.  Patients may present with disseminated intravascular coagulation.  This AML has an intermediate survival.  (WHO, 2001) -- 2003
C6925	Anal_Margin_Squamous_Cell_Carcinoma	Anal_Margin_Carcinoma|Anal_Squamous_Cell_Carcinoma	Anal Margin Squamous Cell Carcinoma|Perianal Skin Squamous Cell Carcinoma|Squamous Cell Carcinoma of Anal Margin|Squamous Cell Carcinoma of the Anal Margin
C6926	Stromal_Sarcoma	Soft_Tissue_Sarcoma|Stromal_Neoplasm	Stromal Sarcoma	A rare malignant growth of the body of the uterus. There are multiple types, of which the most clinically relevant are the carcinosarcoma, the leiomyosarcoma, the endometrial stromal sarcoma, and the mullerian adenosarcoma.
C6927	Malignant_Epithelioma	Epithelioma	Malignant Epithelioma
C6928	Epithelioma	Epithelial_Neoplasm	Epithelioma
C6929	Malignant_Thecoma	Malignant_Ovarian_Sex_Cord-Stromal_Tumor|Thecoma	Malignant Ovarian Thecoma|Malignant Ovarian Thecal Cell Neoplasm|Malignant Ovarian Thecal Cell Tumor|Malignant Thecal Cell Neoplasm of Ovary|Malignant Thecal Cell Neoplasm of the Ovary|Malignant Thecal Cell Tumor of Ovary|Malignant Thecal Cell Tumor of the Ovary|Malignant Thecoma of Ovary|Malignant Thecoma of the Ovary
C6930	Mixed_Neoplasm	Neoplasm_by_Morphology	Mixed Neoplasm|Mixed Tumor	A tumor composed of at least two distinct cellular populations. --2003
C6932	Solitary_Plasmacytoma	Plasmacytoma	Solitary Plasmacytoma	A single focus of clonal (malignant) plasma cells either in the bone or in another anatomic site without peripheral blood involvement. --2003
C6933	Middle_Ear_Polyp	Ear_Polyp	Middle Ear Polyp|Polyp of Middle Ear|Polyp of the Middle Ear
C6934	Gangliocytoma	Neuronal_and_Mixed_Neuronal-Glial_Tumor	Gangliocytoma	Gangliocytoma (WHO grade I) and Ganglioglioma (WHO grade I or II) are well differentiated, slow growing neuroepithelial neoplasms composed of neoplastic, mature ganglion cells either alone (gangliocytoma), or in combination with neoplastic glial cells (ganglioglioma). (Adapted from WHO.)
C6935	Spinal_Cord_Meningioma	Intraspinal_Meningioma|Spinal_Cord_Neoplasm	Spinal Cord Meningioma|Meningioma of Spinal Cord|Meningioma of the Spinal Cord
C6936	Aggressive_Angiomyxoma	Angiomyxoma	Deep Angiomyxoma|Aggressive Angiomyxoma
C6938	Sweat_Gland_Carcinoma	Adnexal_Carcinoma|Malignant_Sweat_Gland_Neoplasm	Sweat Gland Carcinoma|Carcinoma of Sweat Gland|Carcinoma of the Sweat Gland
C6939	Ductal_Carcinoma_in_situ_and_Infiltrating_Lobular_Carcinoma	Intraductal_and_Lobular_Carcinoma|Invasive_Breast_Carcinoma	Ductal Breast Carcinoma In Situ and Invasive Lobular Carcinoma|DCIS and ILC|DCIS and Infiltrating Lobular Carcinoma|Ductal Carcinoma in situ and Infiltrating Lobular Carcinoma|Non-Infiltrating Ductal Carcinoma and ILC|Non-Infiltrating Ductal Carcinoma and Infiltrating Lobular Carcinoma
C6940	Breast_Fibrocystic_Change_Proliferative_Type	Breast_Fibrocystic_Change	Breast Fibrocystic Change, Proliferative Type|Benign Proliferative Breast Disease|Proliferative Breast Disease|Proliferative Breast Lesion|Proliferative Fibrocystic Change|Proliferative Type Fibrocystic Change of Breast|Proliferative Type Fibrocystic Change of the Breast|benign proliferative breast disease	A group of noncancerous conditions that may increase the risk of developing breast cancer.  Examples include ductal hyperplasia, lobular hyperplasia, and papillomas.
C6941	Blunt_Duct_Adenosis_of_the_Breast	Breast_Adenosis|Breast_Fibrocystic_Change_Non-Proliferative_Type	Breast Blunt Duct Adenosis|Blunt Duct Adenosis of Breast|Blunt Duct Adenosis of the Breast
C6942	Simple_Adenosis_of_the_Breast	Retired_Concepts	Simple Adenosis of the Breast
C6943	Breast_Fibrocystic_Change_Non-Proliferative_Type	Breast_Fibrocystic_Change	Breast Fibrocystic Change, Non-Proliferative Type|Non-Proliferative Fibrocystic Change|Non-Proliferative Fibrocystic Change of Breast|Non-Proliferative Fibrocystic Change of the Breast
C6944	Atypical_Metaplasia	Metaplasia	Atypical Metaplasia
C6947	Cardiac_Fibroelastic_Hamartoma	Benign_Cardiac_Neoplasm|Fibroma	Cardiac Fibroma|Cardiac Fibroelastic Hamartoma|Cardiac Fibrous Hamartoma|Fibroelastic Hamartoma of Heart|Fibroelastic Hamartoma of the Heart|Heart Fibroelastic Hamartoma|Heart Fibroma|Heart Fibrous Hamartoma
C6948	Postoperative_Spindle_Cell_Nodule	Benign_Fibrous_Soft_Tissue_Neoplasm	Postoperative Spindle Cell Nodule|Posttraumatic Spindle Cell Nodule
C6949	Postoperative_Spindle_Cell_Nodule_of_the_Bladder	Benign_Bladder_Neoplasm|Postoperative_Spindle_Cell_Nodule	Postoperative Spindle Cell Nodule of the Bladder|Postoperative Spindle Cell Nodule of Bladder|Postoperative Spindle Cell Nodule of Urinary Bladder|Postoperative Spindle Cell Nodule of the Urinary Bladder|Posttraumatic Spindle Cell Nodule of Bladder|Posttraumatic Spindle Cell Nodule of Urinary Bladder|Posttraumatic Spindle Cell Nodule of the Bladder|Posttraumatic Spindle Cell Nodule of the Urinary Bladder
C6950	Benign_Kidney_Hemangiopericytoma	Benign_Hemangiopericytoma|Benign_Renal_Neoplasm|Kidney_Hemangiopericytoma	Benign Renal Hemangiopericytoma|Benign Hemangiopericytoma of Kidney|Benign Hemangiopericytoma of the Kidney|Benign Kidney Hemangiopericytoma
C6951	Nonanaplastic_Wilms_Tumor	Renal_Wilms_Tumor	Nonanaplastic Renal Wilms' Tumor|Nonanaplastic Renal Wilm's Tumor|Nonanaplastic Renal Wilms Tumor
C6952	Anaplastic_Wilms_Tumor	Renal_Wilms_Tumor	Anaplastic Renal Wilms' Tumor|Anaplastic Renal Wilm's Tumor|Anaplastic Renal Wilms Tumor
C6954	Adult_Brain_Stem_Astrocytoma	Adult_Brain_Stem_Glioma|Brain_Stem_Astrocytoma	Adult Brain Stem Astrocytoma|Adult Brainstem Astrocytoma
C6955	Olfactory_Neural_Neoplasm	Intracranial_Neoplasm	Olfactory Neural Neoplasm|Olfactory Neural Tumor
C6956	Retinal_Neuroblastoma	Neuroblastoma	Retinal Neuroblastoma|Neuroblastoma of Retina|Neuroblastoma of the Retina
C6957	Childhood_Cerebral_Ependymoblastoma	Ependymoblastoma|Malignant_Childhood_Central_Nervous_System_Neoplasm	Childhood Cerebral Ependymoblastoma|Pediatric Cerebral Ependymoblastoma
C6958	Astrocytic_Tumor	Central_Nervous_System_Neoplasm|Common_Neoplasm|Neuroglial_Tumor	Astrocytic Tumor|Astrocytic Neoplasm|Astrocytic glioma|Astrocytoma|Astrocytomas|Astroglioma|astrocytoma	(as-troe-sye-TOE-ma) A tumor that begins in the brain or spinal cord in small, star-shaped cells called astrocytes.
C6959	Anaplastic_Oligoastrocytoma	Malignant_Glioma|Mixed_Glioma	Anaplastic Oligoastrocytoma|WHO Grade III Mixed Glioma	Anaplastic Oligoastrocytoma is an Oligoastrocytoma with histological features of malignancy, such as increased cellularity, nuclear atypia, pleomorphism, and increased mitotic activity. (WHO)
C6960	Oligodendroglial_Tumor	Central_Nervous_System_Neoplasm|Neuroglial_Tumor	Oligodendroglial Tumor|Oligodendroglial Neoplasm|oligodendroglial tumor	A rare, slow-growing tumor that begins in the oligodendrocytes (brain cells that provide support and nourishment for nerve cells).  Also called an oligodendroglioma.
C6961	Chordoid_Glioma_of_the_Third_Ventricle	Chordoid_Glioma|Intraventricular_Brain_Neoplasm	Chordoid Glioma of the Third Ventricle|Chordoid Glioma of 3rd Ventricle|Chordoid Glioma of Third Ventricle|Chordoid Glioma of the 3rd Ventricle|Third Ventricle Chordoid Glioma	Chordoid Glioma of the 3rd Ventricle is a rare, slow growing, glial tumor located in the third ventricle of adults. It is characterized histologically by clusters and cords of epithelioid, GFAP expressing tumor cells within a stroma with varying amounts of mucin, which typically contains a lymphoplasmacytic infiltrate. (Adapted from WHO.)
C6962	Paraganglioma_of_the_Filum_Terminale	Retired_Concepts	Paraganglioma of the Filum Terminale|Paraganglioma of Filum Terminale
C6963	Neuroblastic_Tumor	Neuroectodermal_Tumor	Neuroblastic Tumor	Peripheral Neuroblastic Tumors - Neuroblastic Tumors outside the central nervous system - are clinically important neoplasms.  They display a wide range of neuronal differentiation, from highly cellular, immature round cell tumors to lesions with advanced differentiation and formation of mature ganglion cells. (Adapted from WHO.)
C6964	Neuroblastomas_of_the_Adrenal_Gland_and_Sympathetic_Nervous_System	Peripheral_Neuroblastoma	Neuroblastoma of the Adrenal Gland and Sympathetic Nervous System|Neuroblastomas of Adrenal Gland and Sympathetic Nervous System	A common pediatric extracranial tumor arising from neural crest cells.  It involves the adrenal medulla and the sympathetic nervous system.
C6965	Pineal_Parenchymal_Cell_Neoplasm	Neuroepithelial_Neoplasm|Pineal_Region_Neoplasm	Pineal Parenchymal Cell Neoplasm|Neoplasm of Pineal Gland|Neoplasm of the Pineal Gland|Pineal Gland Neoplasm|Pineal Gland Tumor|Pineal Parenchymal Cell Tumor|Pineal Parenchymal Neoplasm|Pineal Parenchymal Tumor|Pineocytic Neoplasm|Pineocytic Tumor|Tumor of Pineal Gland|Tumor of the Pineal Gland	Pineal parenchymal tumors are neoplasms of the pineocyte, a cell with photosensory and neuroendocrine functions. These tumors have a wide spectrum, with tumors composed of mature elements to ones consisting of primitive, immature cells. These tumors also have differences in biological behavior and clinical outcome.  Three types are: Pineoblastoma, Pineocytoma, Pineal Parenchymal Tumor of Intermediate Differentiation (Adapted from WHO.)
C6966	Pineocytoma	Benign_Pineal_Region_Neoplasm|Pineal_Parenchymal_Cell_Neoplasm	Pineocytoma|pineocytoma	(PIN-ee-o-sye-TOE-ma) A slow growing type of brain tumor that occurs in or around the pineal gland, a tiny organ near the center of the brain.
C6967	Pineal_Parenchymal_Tumor_of_Intermediate_Differentiation	Pineal_Parenchymal_Cell_Neoplasm	Pineal Parenchymal Tumor of Intermediate Differentiation	Pineal Parenchymal Tumors of Intermediate Differentiation are monomorphous tumors characterized by moderately high cellularity, mild nuclear atypia, occasional mitosis, and the absence of large pineocytomatous rosettes. They occur at all ages, from young children to adults, with a peak incidence in adulthood. Clinical behavior is variable. (Adapted from WHO.)
C6968	Supratentorial_Primitive_Neuroectodermal_Tumor	Central_Nervous_System_Primitive_Neuroectodermal_Tumor|Intracranial_Primitive_Neuroectodermal_Neoplasm|Malignant_Supratentorial_Neoplasm	Supratentorial Primitive Neuroectodermal Tumor|Supratentorial PNET	Supratentorial Primitive Neuroectodermal Tumor (PNET) (WHO grade IV) is an embryonal tumor located in the cerebrum or suprasellar region. It is composed of undifferentiated or poorly differentiated neuroepithelial cells which may display neuronal, astrocytic, ependymal, muscular or melanocytic differentiation. Cerebral neuroblastomas have distinct neuronal differentiation and Ganglioneuroblastomas have ganglion cells present. (Adapted from WHO.)
C6969	Plexiform_Schwannoma	Schwannoma	Plexiform Schwannoma|Plexiform Neurilemmoma|Plexiform Neurinoma	Plexiform Schwannoma (also called Plexiform Neurilemmoma and Plexiform Neurinoma) is a Schwannoma which grows in a plexiform or multinodular manner, presumably involving a nerve plexus. The majority arise in skin or subcutaneous tissue of an extremity, head and neck or trunk. The tumor is associated with Neurofibromatosis Type 1. (Adapted from WHO.)
C6970	Melanocytic_Schwannoma	Schwannoma	Melanocytic Schwannoma|Melanocytic Neurilemmoma|Melanotic Neurilemmoma|Melanotic Neurinoma|Melanotic Schwannoma|Pigmented Neurilemmoma|Pigmented Schwannoma	Melanotic Schwannoma (also called Melanotic Neurilemmoma or Melanotic Neurinoma) is a rare type of Schwannoma which is circumscribed, pigmented and composed of cells with the ultrastructure and immunophenotype of Schwann cells, but which contain melanosomes that are reactive for melanoma markers. (Adapted from WHO.)
C6971	Meningothelial_Cell_Neoplasm	Neoplasm_by_Morphology	Meningothelial Cell Neoplasm|Meningothelial Cell Tumor|Primary Meningeal Neoplasm|Primary Meningeal Tumor|Tumor of Meningothelial Cells
C6972	Mesenchymal_Non-Meningothelial_Tumor_of_the_Central_Nervous_System	Central_Nervous_System_Soft_Tissue_Neoplasm	Mesenchymal Non-Meningothelial Tumor of the Central Nervous System|Mesenchymal, Non-Meningothelial Tumor of CNS|Mesenchymal, Non-Meningothelial Tumor of Central Nervous System|Mesenchymal, Non-Meningothelial Tumor of the CNS	Mesenchymal, Non-Meningothelial Tumors are benign and malignant mesenchymal tumors originating in the CNS or the meninges and showing fibrous, fibrohistiocytic, adipose, myoid, endothelial, chondroid or osseous, but not meningothelial differentiation. Depending on their histological features and clinical behavior, their grade ranges from benign neoplasms (WHO grade I) to highly malignant sarcomas (WHO grade IV). (Adapted from WHO.)
C6973	Intracranial_Liposarcoma	Central_Nervous_System_Sarcoma|Liposarcoma|Malignant_Intracranial_Neoplasms_By_Morphology	Intracranial Liposarcoma	Intracranial liposarcoma is an extremely rare tumor that may be associated with subdural hematomas. (Adapted from WHO.)
C6974	Neoplasm_of_Uncertain_Histogenesis	Neoplasm_by_Morphology	Neoplasm of Uncertain Histogenesis|Neoplasm of Uncertain Origin|Tumor of Uncertain Histogenesis|Tumor of Uncertain Origin
C6975	Papillary_Renal_Cell_Carcinoma	Renal_Cell_Carcinoma	Papillary Renal Cell Carcinoma|Chromophil Carcinoma of Kidney|Chromophil Carcinoma of the Kidney|Chromophil Renal Cell Carcinoma|Papillary (Chromophil) Renal Cell Carcinoma	Also known as chromophil carcinoma, it represents a minority of renal cell carcinomas.  It can be hereditary or sporadic.  The sporadic papillary renal cell carcinoma is characterized by trisomy of chromosomes 7, 16, and 17, and loss of chromosome Y.  The peak incidence is in the sixth and seven decades.  It is classified as type 1 or 2, based on the cytoplasmic volume and the thickness of the lining neoplastic cells. The prognosis is more favorable than for conventional (clear cell) renal cell carcinoma. -- 2003
C6976	Breast_Papilloma	Retired_Concepts	Breast Papilloma|Papilloma of the Breast
C6977	Breast_Papillomatosis	Benign_Breast_Neoplasm|Papillomatosis	Breast Papillomatosis|Papillomatosis of Breast|Papillomatosis of the Breast
C6979	Squamous_Cell_Carcinoma_of_the_Penis_Usual_Type	Squamous_Cell_Carcinoma_of_the_Penis	Squamous Cell Carcinoma of the Penis, Usual Type|Penile Squamous Cell Carcinoma, Usual Type|Squamous Cell Carcinoma of Penis, Usual Type
C6980	Basaloid_Carcinoma_of_the_Penis	Basaloid_Carcinoma|Squamous_Cell_Carcinoma_of_the_Penis	Basaloid Carcinoma of the Penis|Basaloid Carcinoma of Penis|Basaloid Penile Squamous Cell Carcinoma|Basaloid Squamous Cell Carcinoma of Penis|Basaloid Squamous Cell Carcinoma of the Penis|Squamous Cell Carcinoma of Penis, Basaloid Type|Squamous Cell Carcinoma of the Penis, Basaloid Type
C6981	Warty_Carcinoma_of_the_Penis	Human_Papilloma_Virus-Related_Penile_Squamous_Cell_Carcinoma	Warty Carcinoma of the Penis|Condylomatous Carcinoma of Penis|Condylomatous Carcinoma of the Penis|Condylomatous Penile Squamous Cell Carcinoma|Condylomatous Squamous Cell Carcinoma of Penis|Condylomatous Squamous Cell Carcinoma of the Penis|Squamous Cell Carcinoma of Penis, Condylomatous Type|Squamous Cell Carcinoma of Penis, Warty Type|Squamous Cell Carcinoma of the Penis, Condylomatous Type|Squamous Cell Carcinoma of the Penis, Warty Type|Warty Carcinoma of Penis|Warty Penile Squamous Cell Carcinoma|Warty Squamous Cell Carcinoma of Penis|Warty Squamous Cell Carcinoma of the Penis
C6982	Verrucous_Carcinoma_of_the_Penis	Squamous_Cell_Carcinoma_of_the_Penis	Verrucous Carcinoma of the Penis|Squamous Carcinoma of Penis, Verrucous Type|Squamous Carcinoma of the Penis, Verrucous Type|Verrucous Carcinoma of Penis|Verrucous Penile Carcinoma|Verrucous Penile Squamous Carcinoma|Verrucous Squamous Carcinoma of Penis|Verrucous Squamous Carcinoma of the Penis
C6983	Papillary_Carcinoma_of_the_Penis	Squamous_Cell_Carcinoma_of_the_Penis	Papillary Carcinoma of the Penis|Papillary Carcinoma of Penis|Papillary Penile Carcinoma|Papillary Penile Squamous Carcinoma|Papillary Squamous Carcinoma of Penis|Papillary Squamous Carcinoma of the Penis|Squamous Carcinoma of Penis, Papillary Type|Squamous Carcinoma of the Penis, Papillary Type
C6984	Sarcomatoid_Carcinoma_of_the_Penis	Sarcomatoid_Squamous_Cell_Carcinoma|Squamous_Cell_Carcinoma_of_the_Penis	Sarcomatoid Carcinoma of the Penis|Sarcomatoid Penile Carcinoma|Sarcomatoid Penile Squamous Cell Carcinoma|Sarcomatous Carcinoma of the Penis|Spindle Cell Carcinoma of the Penis|Squamous Cell Carcinoma of Penis, Sarcomatoid Type|Squamous Cell Carcinoma of the Penis, Sarcomatoid Type
C6985	Invasive_Hydatidiform_Mole	Hydatidiform_Mole	Invasive Hydatidiform Mole|Chorioadenoma|Chorioadenoma Destruens|Invasive Gestational Trophoblastic Neoplasm|Invasive Mole	This term is used when a complete mole or very rarely a partial mole invades the myometrium.  Clinical presentation includes: abnormal uterine ultra sound and either persistent or rising hCG levels. - 2002
C6986	Breast_Myoepithelioma	Retired_Concepts	Breast Myoepithelioma|Myoepithelioma of Breast|Myoepithelioma of the Breast
C6987	Ductal_Breast_Carcinoma_with_Squamous_Metaplasia	Breast_Adenocarcinoma_with_Squamous_Metaplasia|Ductal_Breast_Carcinoma	Ductal Breast Carcinoma with Squamous Metaplasia|Ductal Carcinoma of Breast with Squamous Metaplasia|Ductal Carcinoma of the Breast with Squamous Metaplasia
C6988	Oligoastrocytoma	Retired_Concepts	Oligoastrocytoma|WHO Grade II Mixed Glioma
C6989	Subependymal_Astrocytoma	Astrocytic_Tumor	Subependymal Astrocytoma	Subependymoma (WHO grade I) is a benign, slow growing neoplasm which is typically attached to a ventricular wall. It is composed of glial tumor cell clusters embedded in an abundant fibrillary matrix with frequent microcystic change. Some lesions have the histological features of both subependymoma and ependymoma. It is often detected incidentally and has a very favorable prognosis. (Adapted from WHO.)
C6990	Embryonal_Neoplasm_of_the_CNS	Embryonal_Neoplasm|Malignant_Central_Nervous_System_Neoplasm	Central Nervous System Embryonal Neoplasm|CNS Embryonal Neoplasm|CNS Embryonal Tumor|Central Nervous System Embryonal Tumor|Embryonal Neoplasm of CNS|Embryonal Neoplasm of Central Nervous System|Embryonal Neoplasm of the CNS|Embryonal Neoplasm of the Central Nervous System|Embryonal Tumor of CNS|Embryonal Tumor of Central Nervous System|Embryonal Tumor of the CNS|Embryonal Tumor of the Central Nervous System	Embryonal tumors are a large and important fraction of pediatric brain tumors. The following histologically identifiable entities all develop on the background of an undifferentiated round-cell tumor but show a variety of divergent patterns of differentiation. It has been proposed that they be merged under the term primitive neuroectodermal tumors: Ependymoblastoma, Medulloblastoma and Supratentorial PNETs. Two other entities should be kept separate as they have a distinctly different histology and also appear to evolve by different genetic pathways: Medulloepithelioma and Atypical Teratoid/Rhabdoid Tumor. (Adapted from WHO.)
C6991	Simple_Endometrial_Hyperplasia_with_Atypia	Atypical_Endometrial_Hyperplasia|Simple_Endometrial_Hyperplasia	Simple Endometrial Hyperplasia with Atypia
C6992	Simple_Endometrial_Hyperplasia_without_Atypia	Endometrial_Hyperplasia_without_Atypia|Simple_Endometrial_Hyperplasia	Simple Endometrial Hyperplasia without Atypia
C6993	Complex_Endometrial_Hyperplasia_without_Atypia	Complex_Endometrial_Hyperplasia|Endometrial_Hyperplasia_without_Atypia	Complex Endometrial Hyperplasia without Atypia
C6994	Oculomotor_Nerve_Neoplasm	Cranial_Nerve_Neoplasm	Oculomotor Nerve Neoplasm|Cranial Nerve III Tumor|IIIrd Cranial Nerve Tumor|Oculomotor Nerve Tumor
C6995	Malignant_Oculomotor_Nerve_Neoplasm	Malignant_Cranial_Nerve_Neoplasm|Oculomotor_Nerve_Neoplasm	Malignant Oculomotor Nerve Neoplasm|IIIrd Cranial Nerve Neoplasm, Malignant|Oculomotor Nerve Neoplasm, Malignant
C6996	Uterine_Adenomyosis	Uterine_Corpus_Non-Neoplastic_Disorder	Uterine Adenomyosis|Adenomyosis|Adenomyosis of Uterus|Adenomyosis of the Uterus|Uterus Corpus Adenomyosis
C6997	Hibernoma_of_the_Nervous_System	Hibernoma|Mesenchymal_Non-Meningothelial_Tumor_of_the_Central_Nervous_System	Hibernoma of the Central Nervous System|Hibernoma of Central Nervous System
C6998	Leiomyoma_of_the_Central_Nervous_System	Leiomyoma|Mesenchymal_Non-Meningothelial_Tumor_of_the_Central_Nervous_System	Leiomyoma of the Central Nervous System|Central Nervous System Leiomyoma|Leiomyoma of CNS|Leiomyoma of Central Nervous System|Leiomyoma of the CNS	A benign smooth muscle tumor of the central nervous system.  Hiistologically it has a pattern of intersecting fascicles, composed of eosinophilic spindle cells with blunt-ended nuclei that often lack mitotic activity. Occasional tumors have nuclear palisading, but should not be mistaken for schwannomas. Diffuse leptomeningeal leiomyomas and the angioleiomyomatous variant have been described and several AIDS-associated cases have been reported. (Adapted from WHO.)
C6999	Leiomyosarcoma_of_the_Central_Nervous_System	Central_Nervous_System_Sarcoma|Leiomyosarcoma	Leiomyosarcoma of the Central Nervous System|CNS Leiomyosarcoma|Leiomyosarcoma of CNS|Leiomyosarcoma of Central Nervous System|Leiomyosarcoma of the CNS	Intracranial leiomyosarcomas are malignant smooth muscle tumors, generally arising in the dura, although one unique example originating in a pineal teratoma has been reported.  (Adapted from WHO.)
C7000	Rhabdomyoma_of_the_Central_Nervous_System	Mesenchymal_Non-Meningothelial_Tumor_of_the_Central_Nervous_System|Rhabdomyoma	Rhabdomyoma of the Central Nervous System|Rhabdomyoma of Central Nervous System	Rhabdomyoma is a tumor that generally consists entirely of mature striated muscle. One reported Rhabdomyoma associated with a cranial nerve had a minor adipose tissue component. CNS Rhabdomyomas must be distinguished from skeletal muscle heterotopias, most of which occur within prepontine leptomeninges. (Adapted from WHO.)
C7001	Chondroma_of_the_Central_Nervous_System	Extraskeletal_Chondroma|Mesenchymal_Non-Meningothelial_Tumor_of_the_Central_Nervous_System	Chondroma of the Central Nervous System|CNS Chondroma|Chondroma of CNS|Chondroma of Central Nervous System|Chondroma of the CNS	Chondroma, Osteoma and Osteochondroma are benign osteocartilaginous tumors which are usually dura-based. Outside the CNS, they often develop in the skull and only secondarily displace dura and brain. Histologically, they correspond to similar tumors arising in bone, but should be differentiated from asymptomatic dural calcification, ossification related to metabolic disease or trauma, and neuroectodermal tumors such as astrocytoma and gliosarcoma that occasionally show osseous or chondroid differentiation. Conversion of a CNS chondroma to a chondrosarcoma has rarely been documented. (Adapted from WHO.)
C7002	Osteosarcoma_of_the_Central_Nervous_System	Central_Nervous_System_Sarcoma|Extraskeletal_Osteosarcoma	Osteosarcoma of the Central Nervous System|Osteosarcoma of Central Nervous System	The preferred sites of Osteosarcoma, a malignant tumor of bone, are the skull or spine and, more rarely, the meninges or the brain. The diagnosis is made by seeing direct formation of bone or osteoid by the proliferating tumor cells. Osteosarcomatous elements may rarely be found in germ cell tumors and gliosarcomas.  (Adapted from WHO.)
C7003	Osteochondroma_of_the_Central_Nervous_System	Extraskeletal_Osteochondroma|Mesenchymal_Non-Meningothelial_Tumor_of_the_Central_Nervous_System	Osteochondroma of the Central Nervous System|CNS Osteochondroma|Central Nervous System Osteochondroma|Osteochondroma of CNS|Osteochondroma of Central Nervous System|Osteochondroma of the CNS	Chondroma, Osteoma and Osteochondroma are benign osteocartilaginous tumors which are usually dura-based. Outside the CNS, they often develop in the skull and only secondarily displace dura and brain. Histologically, they correspond to similar tumors arising in bone, but should be differentiated from asymptomatic dural calcification, ossification related to metabolic disease or trauma, and neuroectodermal tumors such as astrocytoma and gliosarcoma that occasionally show osseous or chondroid differentiation. (Adapted from WHO.)
C7004	Hemangioma_of_the_Central_Nervous_System	Hemangioma|Mesenchymal_Non-Meningothelial_Tumor_of_the_Central_Nervous_System	Hemangioma of the Central Nervous System|Central Nervous System Hemangioma|Hemangioma of CNS|Hemangioma of Central Nervous System|Hemangioma of the CNS	Hemangiomas, tumors composed chiefly of blood vessels, vary in size from microscopic to massive. They are classified as capillary or cavernous, depending upon their histological appearance. Most hemangiomas that affect the CNS are primary lesions of bone that impinge secondarily on the CNS. (Adapted from WHO.)
C7005	Hemangiopericytoma_of_the_Central_Nervous_System	Hemangiopericytoma|Mesenchymal_Non-Meningothelial_Tumor_of_the_Central_Nervous_System	Hemangiopericytoma of the Central Nervous System|Hemangiopericytoma of Central Nervous System	Hemangiopericytoma (HPC) (generally, WHO grade II or III) of the central nervous system is a rare, highly cellular and richly vascularized tumor, almost always attached to the dura, and indistinguishable histologically from Hemangiopericytomas occuring in somatic soft tissues. It has a tendency to recur and to metastasize outside the CNS. (Adapted from WHO.)
C7006	Kaposi_Sarcoma_of_the_Central_Nervous_System	Central_Nervous_System_Sarcoma|Kaposi_s_Sarcoma	Kaposi Sarcoma of the Central Nervous System|CNS Kaposi Sarcoma|Central Nervous System Kaposi Sarcoma|Kaposi Sarcoma of CNS|Kaposi Sarcoma of Central Nervous System|Kaposi Sarcoma of the CNS	Kaposi Sarcoma is a malignant neoplasm characterized by spindle-shaped cells lining or forming slit-like blood vessels. It is rarely found as a brain parenchymal or meningeal tumor in the setting of AIDS. (Adapted from WHO.)
C7007	Hemangioblastoma_of_the_Central_Nervous_System	Central_Nervous_System_Soft_Tissue_Neoplasm|Hemangioblastoma	Central Nervous System Capillary Hemangioblastoma|CNS Hemangioblastoma|Central Nervous System Hemangioblastoma|Hemangioblastoma of CNS|Hemangioblastoma of Central Nervous System|Hemangioblastoma of the CNS	Capillary Hemangioblastoma (WHO grade I) is a tumor of uncertain histogenesis which is composed of stromal cells and abundant capillaries. Approximately 25% of Hemangioblastomas are associated with Von Hippel-Lindau disease, a disease inherited through an autosomal dominant trait and characterized by the development of Capillary Hemangioblastomas of the central nervous system and retina, clear cell renal carcinoma, pheochromocytoma, pancreatic and inner ear tumors. (Adapted from WHO.)
C7008	Intracranial_Myeloid_Sarcoma	Central_Nervous_System_Leukemia|Myeloid_Sarcoma	Intracranial Myeloid Sarcoma|Intracranial Chloroma
C7009	Germinoma_of_the_Central_Nervous_System	Central_Nervous_System_Germ_Cell_Neoplasm|Germinoma	Central Nervous System Germinoma|Germinoma of CNS|Germinoma of Central Nervous System|Germinoma of the CNS|Germinoma of the Central Nervous System	The pure Germinoma is the most common CNS Germ Cell Tumor.  It is composed of uniform cells resembling primitive germ cells.  These cells have large, vesicular nuclei, prominent nucleoli and a clear, glycogen-rich cytoplasm.  Additional features are lymphoid or lymphoplasmacellular infiltrates and, less frequently, scattered syncytiotrophoblastic giant cells.  (Adapted from WHO.)
C7010	Embryonal_Carcinoma_of_the_CNS	Central_Nervous_System_Germ_Cell_Neoplasm|Extragonadal_Embryonal_Carcinoma	Central Nervous System Embryonal Carcinoma|Embryonal Carcinoma of CNS|Embryonal Carcinoma of the Central Nervous System	Embryonal Carcinoma is composed of large cells that proliferate in cohesive nests and sheets, form abortive papillae, or line irregular, gland-like spaces. In rare occasions, tumor cells may replicate the structure of the early embryo, forming "embryoid bodies" replete with germ discs and miniature amniotic cavities. The tumors also have enlarged nucleoli, abundant clear to somewhat violet-hued cytoplasm, a high mitotic rate and zones of coagulative necrosis.  (Adapted from WHO.)
C7011	Yolk_Sac_Tumor_of_the_CNS	Central_Nervous_System_Germ_Cell_Neoplasm|Yolk_Sac_Tumor	Central Nervous System Yolk Sac Tumor|CNS Yolk Sac Tumor|Yolk Sac Tumor of CNS|Yolk Sac Tumor of Central Nervous System|Yolk Sac Tumor of the CNS|Yolk Sac Tumor of the Central Nervous System	Yolk Sac Tumor is composed of primitive-appearing epithelial cells - putatively representing yolk sac endoderm - set in a loose, variably cellular, and often conspicuously myxoid matrix, resembling extra-embryonic mesoblast. Eosinophilic hyaline globules immunoreactive for AFP are a diagnostic feature. (WHO)
C7012	Central_Nervous_System_Choriocarcinoma	Central_Nervous_System_Germ_Cell_Neoplasm|Choriocarcinoma	Central Nervous System Choriocarcinoma|Choriocarcinoma of CNS|Choriocarcinoma of the CNS	Choriocarcinoma is characterized by extra-embryonic differentiation along trophoblastic lines. The diagnosis requires the identification of cytotrophoblastic elements, as well as syncitiotrophoblastic giant cells. (WHO)
C7013	Central_Nervous_System_Mature_Teratoma	Central_Nervous_System_Teratoma	Central Nervous System Mature Teratoma|CNS Mature Teratoma|Mature Teratoma of CNS|Mature Teratoma of Central Nervous System|Mature Teratoma of the CNS|Mature Teratoma of the Central Nervous System	Mature Teratomas are tumors composed exclusively of fully differentiated, 'adult-type' tissue elements that are sometimes arranged in a pattern resembling normal tissue relationships. Mitotic activity is low or absent. The more common ectodermal components found in Mature Teratomas include skin, brain and choroid plexus. The more common mesodermal components include cartilage, bone, fat and muscle (both smooth and striated). And the most common endodermal components are cysts lined by epithelia of respiratory or enteric type and in some cases pancreatic or hepatic tissue.  (Adapted from WHO.)
C7014	Central_Nervous_System_Immature_Teratoma	Central_Nervous_System_Teratoma	Central Nervous System Immature Teratoma|CNS Immature Teratoma|Immature Teratoma of CNS|Immature Teratoma of Central Nervous System|Immature Teratoma of the CNS|Immature Teratoma of the Central Nervous System	Immature Teratoma is a variant of Teratoma composed of incompletely differentiated components resembling fetal tissues. Even if the immature component is only a minor element of an otherwise differentiated tumor, the tumor is still classified as immature. (Adapted from WHO.)
C7015	Teratoma_of_the_CNS_with_Malignant_Transformation	Central_Nervous_System_Teratoma|Teratoma_with_Malignant_Transformation	Teratoma of the CNS with Malignant Transformation|CNS Teratoma with Malignant Transformation|Central Nervous System Teratoma with Malignant Transformation|Teratoma of CNS with Malignant Transformation|Teratoma of Central Nervous System with Malignant Transformation|Teratoma of the Central Nervous System with Malignant Transformation	The term 'Teratoma with Malignant Transformation' is a generic designation for the occasional teratomatous neoplasm that contains as an additional malignant component a cancer of conventional somatic type. This malignant component is most often a rhabdomyosarcoma or an undifferentiated sarcoma and less often a squamous cell carcinoma or enteric-type adenocarcinoma. (Adapted from WHO.)
C7016	Mixed_Germ_Cell_Neoplasms_of_the_Central_Nervous_System	Central_Nervous_System_Germ_Cell_Neoplasm|Mixed_Germ_Cell_Neoplasm	Central Nervous System Mixed Germ Cell Tumor|CNS Mixed Germ Cell Tumor|Mixed Germ Cell Neoplasm of the Central Nervous System|Mixed Germ Cell Tumor of CNS|Mixed Germ Cell Tumor of the CNS|Mixed Germ Cell Tumor of the Central Nervous System	These rare Germ Cell Tumors contain mixtures of two or more types of germ cell neoplasia. (Adapted from AFIP Fascicle #23.)
C7017	Granular_Cell_Tumor_of_the_Neurohypophysis	Granular_Cell_Tumor|Neurohypophysis_Neoplasm	Granular Cell Tumor of the Posterior Pituitary Gland|Granular Cell Tumor of Neurohypophysis|Granular Cell Tumor of the Neurohypophysis	Granular Cell Tumor of the posterior lobe of the pituitary gland (WHO grade I) is a generally benign intrasellar and/or suprasellar mass arising from the neurohypophysis or infundibulum, composed of nests of large cells with granular, eosinophilic cytoplasm due to abundant intracytoplasmic lysosomes. It generally has a slow progression and lacks invasive growth. (Adapted from WHO.)
C7018	Neurothekeoma	Peripheral_Nerve_Sheath_Neoplasm|Peripheral_Nervous_System_Neoplasm	Neurothekeoma|Nerve Sheath Myxoma
C7019	Trilateral_Retinoblastoma	Retinoblastoma	Trilateral Retinoblastoma	Trilateral retinoblastoma refers to bilateral (or less often unilateral) retinoblastoma associated with an intracranial primitive neuroectodermal tumor in the pineal or suprasellar region. This syndrome is often associated with a increased familial incidence of retinoblastoma. (From Cancer 86(1): 135-141, 1999).
C7020	Inflammatory_Pseudotumor_Intracranial	Benign_Intracranial_Neoplasm	Intracranial Inflammatory Pseudotumor|Inflammatory Pseudotumor, Intracranial
C7021	Intracranial_Plasma_Cell_Granuloma	Plasma_Cell_Granuloma	Intracranial Plasma Cell Granuloma
C7022	Gastric_Inflammatory_Myofibroblastic_Tumor	Gastric_Mesenchymal_Neoplasm|Inflammatory_Myofibroblastic_Tumor	Gastric Inflammatory Myofibroblastic Tumor|Gastric Inflammatory Myofibroblastic Neoplasm|Inflammatory Gastric Pseudotumor|Inflammatory Myofibroblastic Neoplasm of Stomach|Inflammatory Myofibroblastic Neoplasm of the Stomach|Inflammatory Myofibroblastic Tumor of Stomach|Inflammatory Myofibroblastic Tumor of the Stomach|Inflammatory Pseudotumor of Stomach|Inflammatory Pseudotumor of the Stomach
C7024	Refractory_Plasma_Cell_Myeloma	Plasma_Cell_Myeloma|Refractory_Plasma_Cell_Neoplasm	Refractory Plasma Cell Myeloma|Refractory Plasma Cell Neoplasm|Refractory Plasma Cell Tumor
C7025	Recurrent_Plasma_Cell_Myeloma	Plasma_Cell_Myeloma|Relapsed_Hematologic_Malignancy	Recurrent Plasma Cell Myeloma|Recurrent Plasma Cell Neoplasm|Recurrent Plasma Cell Tumor
C7027	Barrett_s_Adenocarcinoma	Common_Carcinoma|Esophageal_Adenocarcinoma	Barrett's Adenocarcinoma|Adenocarcinoma Arising in Barrett's Mucosa	Barrett's Adenocarcinoma is an adenocarcinoma arising from Barrett's metaplastic epithelium in the esophagus.  There is evidence supporting the idea that the Barrett's adenocarcinomas develop through a stepwise progression through intestinal metaplastic epithelium to epithelial dysplasia to malignancy.  Adenocarcinomas arising in the setting of Barrett's esophagus are typically papillary and/or tubular.  In terms of grading, they are well or moderately differentiated adenocarcinomas. -- 2002
C7029	Gastric_Heterotopia_of_the_Small_Intestine	Gastrointestinal_System_Finding	Gastric Heterotopia of the Small Intestine|Gastric Heterotopia of Small Intestine
C7030	Gastric_Heterotopia_of_the_Large_Intestine	Gastrointestinal_System_Finding	Gastric Heterotopia of the Large Intestine|Gastric Heterotopia of Large Intestine
C7031	Adenocarcinoid_Tumor_of_the_Appendix	Appendix_Mixed_Endocrine-Exocrine_Neoplasm	Appendix Mixed Carcinoid-Adenocarcinoma|Adenocarcinoid Neoplasm of Appendix|Adenocarcinoid Neoplasm of the Appendix|Adenocarcinoid Tumor of Appendix|Adenocarcinoid Tumor of the Appendix|Appendiceal Adenocarcinoid|Appendiceal Adenocarcinoid Neoplasm|Appendiceal Adenocarcinoid Tumor|Appendix Adenocarcinoid Neoplasm|Appendix Adenocarcinoid Tumor|Appendix Glandular Carcinoid Tumor
C7032	Esophageal_Basaloid_Squamous_Cell_Carcinoma	Basaloid_Carcinoma|Esophageal_Squamous_Cell_Carcinoma	Esophageal Basaloid Carcinoma|Basaloid Squamous Carcinoma of Esophagus|Basaloid Squamous Carcinoma of the Esophagus|Esophageal Basaloid Squamous Cell Carcinoma	A rare morphologic variant of esophageal squamous cell carcinoma.  Histologically, it is composed of closely packed cells with hyperchromatic nuclei and scant basophilic cytoplasm. It has a similar prognosis to the conventional squamous cell carcinoma of the esophagus.  (WHO, 2000) -- 2003
C7033	Gastric_Hyperplastic_Polyp	Gastric_Polyp|Hyperplastic_Polyp	Gastric Hyperplastic Polyp
C7034	Gastric_Juvenile_Polyp	Gastric_Polyp|Juvenile_Polyp	Gastric Juvenile Polyp
C7035	Gastric_Cronkhite_Canada_Polyposis	Gastric_Polyp	Gastric Cronkhite Canada Polyposis
C7036	Gastric_Tubular_Adenoma	Gastric_Adenoma|Tubular_Adenoma	Gastric Tubular Adenoma|Tubular Adenoma of Stomach|Tubular Adenoma of the Stomach
C7037	Gastric_Tubulovillous_Adenoma	Gastric_Adenoma|Tubulovillous_Adenoma	Gastric Tubulovillous Adenoma|Tubulovillous Adenoma of Stomach|Tubulovillous Adenoma of the Stomach
C7038	Gastric_Villous_Adenoma	Gastric_Adenoma|Villous_Adenoma	Gastric Villous Adenoma|Villous Adenoma of Stomach|Villous Adenoma of the Stomach
C7039	Gallbladder_Pancreatic_Heterotopia	Gastrointestinal_System_Finding	Gallbladder Pancreatic Heterotopia
C7040	Central_Nervous_System_Neoplasms_by_Morphology	Retired_Concepts	Central Nervous System Neoplasms by Morphology
C7041	Colon_Tubular_Adenoma	Colonic_Adenoma|Colorectal_Tubular_Adenoma	Colon Tubular Adenoma
C7042	Colon_Ganglioneuroma	Benign_Colon_Neoplasm|Ganglioneuroma	Colon Ganglioneuroma|Colonic Ganglioneuroma
C7044	Intracranial_Central_Nervous_System_Neoplasms_by_Morphology	Retired_Concepts	Intracranial Central Nervous System Neoplasms by Morphology
C7045	Malignant_Intracranial_Neoplasms_By_Morphology	Malignant_Intracranial_Neoplasm	Malignant Intracranial Neoplasms By Morphology
C7046	Urogenital_System_Paraganglioma	Extra-Adrenal_Paraganglioma|Urinary_Tract_Neoplasm	Urinary Tract Paraganglioma|Urinary System Paraganglioma	A benign or malignant extra-adrenal paraganglioma that arises from the urinary tract.  The representative example is bladder paraganglioma.
C7047	Functioning_Pituitary_Gland_Neoplasm	Anterior_Pituitary_Gland_Neoplasm	Functioning Pituitary Gland Neoplasm|Hormone Producing Pituitary Neoplasm|Pituitary Neoplasms, Hormone Producing|Pituitary Tumors, Hormone Producing	A hormone producing pituitary gland adenoma associated with a hormonal syndrome. (NCI05)
C7048	Supratentorial_Meningioma	Intracranial_Meningioma	Supratentorial Meningioma
C7049	Adult_Astrocytic_Tumor	Adult_Central_Nervous_System_Neoplasm|Astrocytic_Tumor	Adult Astrocytic Tumor|Adult Astrocytic Neoplasm|Adult Astrocytic Tumour|Adult Astrocytoma
C7050	Meningioma_by_Morphology	Retired_Concepts	Meningioma by Morphology
C7051	Meningioma_by_Site	Meningioma	Meningioma by Site
C7052	Solitary_Myofibromatosis	Myofibromatosis	Solitary Myofibromatosis|Myofibroma
C7053	Cavernous_Hemangioma_of_the_Face	Cavernous_Hemangioma	Cavernous Hemangioma of the Face|Cavernous Hemangioma of Face
C7054	Childhood_Lymphocyte_Rich_Classical_Hodgkin_s_Lymphoma	Childhood_Hodgkin_s_Lymphoma|Lymphocyte_Rich_Classical_Hodgkin_s_Lymphoma	Childhood Lymphocyte Rich Classical Hodgkin's Lymphoma|Childhood Lymphocyte Rich Classical Hodgkin's Disease|Pediatric Lymphocyte Rich Classical Hodgkin's Disease|Pediatric Lymphocyte Rich Classical Hodgkin's Lymphoma
C7055	Precursor_Lymphoblastic_Leukemia_Lymphoma	Lymphocytic_Neoplasm	Precursor Lymphoblastic Lymphoma/Leukemia|Precursor Lymphoblastic Leukemia/Lymphoma	A neoplasm of immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage.  Neoplasms involving the bone marrow and the peripheral blood are called precursor lymphoblastic leukemias or acute lymphoblastic leukemias.  Neoplasms involving primarily lymph nodes or extranodal sites are called lymphoblastic lymphomas. -- 2003
C7056	Mature_B-Cell_Non-Hodgkin_s_Lymphoma	B-Cell_Non-Hodgkin_s_Lymphoma|Mature_B-Cell_Lymphocytic_Neoplasm	Mature B-Cell Non-Hodgkin's Lymphoma|Mature B-Cell Lymphoma|Mature B-Cell Non-Hodgkin Lymphoma
C7057	Diseases_Disorders_and_Findings	root_node	Disease, Disorder or Finding	Specification of human conditions relevant to cancer.  This includes observations, test results, history, and other concepts relevant to characterization of human cancer-related conditions.  Non-neoplastic conditions of interest are also included.
C7058	Melanocytic_Neoplasm	Neoplasm_by_Morphology	Melanocytic Neoplasm
C7059	Mesenchymal_Cell_Neoplasm	Connective_and_Soft_Tissue_Neoplasm|Neoplasm_by_Morphology	Mesenchymal Cell Neoplasm|Mesenchymal Cell Tumor|Mesenchymal Neoplasm|Mesenchymal Tumor	A benign or malignant, primary or metastatic tumor arising from the mesenchyma-derived cells of the soft tissues or bone.  Representative examples of benign tumors include lipoma and hemangioma; malignant tumors include leiomyosarcoma and osteosarcoma.
C7060	Neural_Cell_Neoplasm	Retired_Concepts	Neural Cell Neoplasm|Neural Cell Tumor
C7061	Retinal_Cell_Neoplasm	Neoplasm_by_Morphology|Retinal_Neoplasm	Retinal Cell Neoplasm|Retinal Cell Tumor
C7062	Neoplasm_by_Special_Category	Neoplasm	Neoplasm by Special Category
C7063	Notochordal_Neoplasm	Embryonal_Neoplasm|Malignant_Bone_Neoplasm|Mesenchymal_Cell_Neoplasm	Notochordal Neoplasm|Notochordal Tumor
C7064	Erythroid_Neoplasm	Myeloid_Neoplasm	Erythroid Neoplasm|Erythroid Tumor
C7065	Lymphocytic_Neoplasm	Hematopoietic_Cell_Neoplasm|Lymphoproliferative_Disorder	Lymphocytic Neoplasm|Lymphocytic Tumor|Lymphocytic and Plasma Cell Neoplasm|Lymphocytic and Plasma Cell Tumor|Lymphocytic and Plasma Cell Tumour|Lymphocytic and Plasmacytic Neoplasm|Lymphoid Neoplasm|Lymphoid Tumor|Lymphoid and Plasma Cell Tumor|Lymphoid and Plasma Cell Tumour|Lymphoid and Plasmacytic Neoplasm|Lymphoid and Plasmacytic Tumor|Lymphoid and Plasmacytic Tumour	A neoplasm composed of a lymphocytic cell population which is usually malignant (clonal) by molecular genetic and/or immunophenotypic analysis.  Lymphocytic neoplasms include Hodgkin's and Non-Hodgkin's lymphomas, acute and chronic lymphocytic leukemias, and plasma cell neoplasms. - 2003
C7066	Megakaryocytic_Neoplasm	Myeloid_Neoplasm	Megakaryocytic Neoplasm|Megakaryocytic Tumor
C7068	Neoplastic_Polyp	Neoplasm_by_Morphology|Polyp|Precancerous_Condition	Neoplastic Polyp
C7069	Giant_Cell_Neoplasm	Neoplasm_by_Morphology	Giant Cell Neoplasm
C7070	Mucinous_Neoplasm	Glandular_Cell_Neoplasm	Mucinous Neoplasm|Mucinous Tumor
C7071	Myoepithelioma	Myoepithelial_Neoplasm	Myoepithelioma
C7072	Oncocytic_Neoplasm	Glandular_Cell_Neoplasm	Oncocytic Neoplasm|Oncocytic Tumor|Oncocytoma	A usually benign neoplasm composed of large cells with abundant eosinophilic granular cytoplasm.  Representative examples include oncocytic neoplasms of the thyroid gland, and kidney. (NCI05)
C7073	Paget_s_Cell_Neoplasm	Adenocarcinoma	Paget's Disease|PD|Paget Cell Neoplasm|Paget Disease|Paget's Cell Neoplasm	A malignant neoplasm composed of large cells with large nuclei, prominent nucleoli, and abundant pale cytoplasm (Paget cells).  Paget's cell neoplasms include Paget's disease of the nipple and extramammary Paget's disease which may affect the vulva, penis, anus, skin and scrotum. -- 2004
C7074	Serous_Neoplasm	Glandular_Cell_Neoplasm	Serous Neoplasm
C7075	Fibrocytic_Neoplasm	Mesenchymal_Cell_Neoplasm	Fibrocytic Neoplasm|Fibrocytic Tumor
C7076	Hemangiopericytic_Neoplasm	Perivascular_Neoplasm	Hemangiopericytic Neoplasm|Hemangiopericytic Tumor
C7077	Common_Neoplasm	Neoplasm_by_Special_Category	Common Neoplasm|Common Tumor
C7078	Neoplasm_by_Morphologic_Variation_and_Secondary_Features	Retired_Concepts	Neoplasm by Morphologic Variation and Secondary Features
C7079	Prostate_Cancer_by_Whitmore-Jewett_Stage	Prostate_Carcinoma	Prostate Cancer by Whitmore-Jewett Stage|Prostate Cancer by Jewett Stage|Prostate Cancer by Whitmore Stage
C7080	Metastatic_Neoplasm_to_the_Prostate	Malignant_Prostate_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Prostate|Metastases to Prostate|Metastases to the Prostate|Metastasis to Prostate|Metastasis to the Prostate|Metastatic Neoplasm to the Prostate|Metastatic Tumor to the Prostate	The spread of cancer to the prostate gland from an adjacent or distant anatomic site
C7081	Colorectal_Cancer_by_Astler-Coller_Stage	Neoplasm_by_Obsolete_Classification	Colorectal Cancer by Astler-Coller Stage
C7082	Colon_Cancer_by_Astler-Coller_Stage	Colorectal_Cancer_by_Astler-Coller_Stage	Colon Cancer by Astler-Coller Stage
C7083	Rectal_Cancer_by_Astler-Coller_Stage	Colorectal_Cancer_by_Astler-Coller_Stage	Rectal Cancer by Astler-Coller Stage
C7085	Small_Intestine_Leiomyosarcoma	Leiomyosarcoma|Small_Intestinal_Sarcoma	Small Intestine Leiomyosarcoma|Leiomyosarcoma of Small Bowel|Leiomyosarcoma of Small Intestine|Leiomyosarcoma of the Small Bowel|Leiomyosarcoma of the Small Intestine|Small Bowel Leiomyosarcoma
C7087	Recurrent_Melanoma	Melanoma	Recurrent Melanoma|Recurrent Malignant Melanoma
C7088	Recurrent_Non-Cutaneous_Melanoma	Non-Cutaneous_Melanoma|Recurrent_Melanoma	Recurrent Non-Cutaneous Melanoma
C7089	Regressing_Melanoma_of_the_Skin	Cutaneous_Melanoma|Regressing_Melanoma	Regressing Skin Melanoma|Regressing Malignant Melanoma of Skin|Regressing Malignant Melanoma of the Skin|Regressing Malignant Skin Melanoma|Regressing Melanoma of Skin|Regressing Melanoma of the Skin
C7090	Regressing_Non-Cutaneous_Melanoma	Non-Cutaneous_Melanoma|Regressing_Melanoma	Regressing Non-Cutaneous Melanoma
C7091	Gastrointestinal_Melanoma	Melanoma	Gastrointestinal Melanoma
C7092	Metastatic_Non-Cutaneous_Melanoma	Metastatic_Melanoma|Non-Cutaneous_Melanoma	Metastatic Non-Cutaneous Melanoma
C7093	Hepatoblastoma_with_Pure_Fetal_Epithelial_Differentiation	Hepatoblastoma	Hepatoblastoma with Pure Fetal Epithelial Differentiation
C7094	Hepatoblastoma_with_Combined_Fetal_Epithelial_Differentiation	Hepatoblastoma	Hepatoblastoma with Combined Fetal Epithelial Differentiation
C7095	Macrotrabecular_Hepatoblastoma	Hepatoblastoma	Macrotrabecular Hepatoblastoma
C7096	Small_Cell_Undifferentiated_Hepatoblastoma	Hepatoblastoma	Small Cell Undifferentiated Hepatoblastoma
C7097	Mixed_Epithelial_and_Mesenchymal_Hepatoblastoma	Hepatoblastoma	Mixed Epithelial and Mesenchymal Hepatoblastoma
C7098	Mixed_Hepatoblastoma_with_Teratoid_Features	Hepatoblastoma	Mixed Hepatoblastoma with Teratoid Features
C7099	Stage_D_Prostate_Cancer	Prostate_Cancer_by_Whitmore-Jewett_Stage	Stage D Prostate Cancer|Cancer of Prostate Stage D|Cancer of the Prostate Stage D|Prostate Cancer Stage D	Metastatic disease. -- 2004
C7100	Undifferentiated_Colon_Carcinoma	Colon_Carcinoma|Colorectal_Undifferentiated_Carcinoma	Colon Undifferentiated Carcinoma|Undifferentiated Carcinoma of Colon|Undifferentiated Carcinoma of the Colon|Undifferentiated Colonic Carcinoma
C7103	Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm	Hepato-Biliary_Neoplasm	Hepatic and Intrahepatic Bile Duct Neoplasm
C7104	Mature_Mediastinal_Teratoma	Mature_Teratoma|Mediastinal_Teratoma	Mediastinal Mature Teratoma|Mature Teratoma of Mediastinum|Mature Teratoma of the Mediastinum
C7105	Exaggerated_Placental_Site	Non-Neoplastic_Non-Molar_Trophoblastic_Disorder	Exaggerated Placental Site
C7106	Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm	Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm	Epithelial Hepatic and Intrahepatic Bile Duct Neoplasm
C7107	Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm	Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm	Non-Epithelial Hepatic and Intrahepatic Bile Duct Neoplasm|Hepatic and Intrahepatic Bile Duct Non-Epithelial Neoplasm
C7109	Distal_Biliary_Tract_Carcinoma	Extrahepatic_Bile_Duct_Carcinoma	Distal Biliary Tract Carcinoma|Carcinoma of Distal Biliary Tract|Carcinoma of the Distal Biliary Tract
C7110	Recurrent_Liver_Cancer	Liver_and_Intrahepatic_Biliary_Tract_Carcinoma|Recurrent_Gastrointestinal_System_Cancer	Recurrent Liver Cancer|Recurrent Cancer of Liver|Recurrent Cancer of the Liver|Recurrent Hepatic Cancer|Relapsed Cancer of Liver|Relapsed Cancer of the Liver|Relapsed Hepatic Cancer|Relapsed Liver Cancer	The reemergence of hepatic neoplasm malignant after a period of remission.
C7111	Benign_Ameloblastoma	Ameloblastoma|Benign_Odontogenic_Neoplasm	Benign Ameloblastoma
C7112	Squamous_Odontogenic_Tumor	Odontogenic_Neoplasm	Squamous Odontogenic Tumor|Squamous Odontogenic Neoplasm
C7113	Endometrioid_Tumor	Epithelial_Neoplasm|Female_Reproductive_System_Neoplasm	Endometrioid Tumor|Endometrioid Neoplasm|Endometrioid Neoplasm of Female Reproductive System|Endometrioid Neoplasm of the Female Reproductive System|Endometrioid Tumor of Female Reproductive System|Endometrioid Tumor of the Female Reproductive System|Female Reproductive Endometrioid Neoplasm|Female Reproductive Endometrioid Tumor
C7114	Thymoma_Type_B	Thymoma	Thymoma Type B|Dendritic Cell Thymoma|Epithelioid Thymoma|Plump Cell Thymoma
C7115	Malignant_Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm	Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Primary_Malignant_Neoplasm_of_Liver	Malignant Non-Epithelial Hepatic and Intrahepatic Bile Duct Neoplasm
C7116	Stage_I_Liver_Cancer	Liver_and_Intrahepatic_Biliary_Tract_Carcinoma	Stage I Liver Cancer|Stage I Liver Carcinoma	Stage I includes: T1, N0, M0.  T1: Solitary tumor without vascular invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C7117	Stage_II_Liver_Cancer	Liver_and_Intrahepatic_Biliary_Tract_Carcinoma	Stage II Liver Cancer|Stage II Liver Carcinoma	Stage II includes: T2, N0, M0.  T2: Solitary tumor with vascular invasion or multiple tumors none more than 5 cm.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C7118	Stage_III_Liver_Cancer	Liver_and_Intrahepatic_Biliary_Tract_Carcinoma	Stage III Liver Cancer|Stage III Liver Carcinoma	Stage III includes: IIIA: (T3, N0, M0); IIIB: (T4, N0, M0); IIIC: (Any T, Any N, M0).  IIIA: T3: Multiple tumors more than 5 cm or tumor involving a major branch of the portal or hepatic vein(s).  T4: Tumors(s) with direct invasion of adjacent organs other than the gallbladder or with perforation of visceral peritoneum.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: Distant metastasis. (AJCC 6th ed.) - 2003
C7119	Stage_IIIA_Liver_Cancer	Stage_III_Liver_Cancer	Stage IIIA Liver Cancer|Stage IIIA Liver Carcinoma
C7120	Stage_IIIB_Liver_Cancer	Stage_III_Liver_Cancer	Stage IIIB Liver Cancer|Stage IIIB Liver Carcinoma
C7121	Stage_IV_Liver_Cancer	Liver_and_Intrahepatic_Biliary_Tract_Carcinoma	Stage IV Liver Cancer|Stage IV Liver Carcinoma	Stage IV includes (Any T, Any N, M1).  M1: Distant metastasis. (AJCC 6th ed.) - 2003
C7122	Stage_IVA_Liver_Cancer	Stage_IV_Liver_Cancer	Stage IVA Liver Cancer|Stage IVA Liver Carcinoma
C7123	Stage_IVB_Liver_Cancer	Stage_IV_Liver_Cancer	Stage IVB Liver Cancer|Stage IVB Liver Carcinoma
C7124	Extrahepatic_Bile_Duct_Papillomatosis	Bile_Duct_Papillomatosis|Extrahepatic_Bile_Duct_Neoplasm	Extrahepatic Bile Duct Papillomatosis|Extrahepatic Biliary Papillomatosis
C7125	Intrahepatic_Bile_Duct_Papillomatosis	Bile_Duct_Papillomatosis|Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Hepatic_Disorder	Intrahepatic Bile Duct Papillomatosis|Intrahepatic Biliary Papillomatosis
C7126	Intrahepatic_Bile_Duct_Adenoma	Bile_Duct_Adenoma|Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Hepatic_Disorder	Intrahepatic Bile Duct Adenoma|Adenoma of Intrahepatic Bile Duct|Adenoma of the Intrahepatic Bile Duct
C7127	Intrahepatic_Bile_Duct_Cystadenoma	Bile_Duct_Cystadenoma|Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Hepatic_Disorder	Intrahepatic Bile Duct Cystadenoma|Cystadenoma of Intrahepatic Bile Duct|Cystadenoma of the Intrahepatic Bile Duct
C7128	Benign_Extrahepatic_Bile_Duct_Non-Epithelial_Neoplasm	Benign_Extrahepatic_Bile_Duct_Neoplasm	Benign Extrahepatic Bile Duct Non-Epithelial Neoplasm
C7129	Benign_Non-Epithelial_Gallbladder_Neoplasm	Benign_Gallbladder_Neoplasm	Benign Non-Epithelial Gallbladder Neoplasm
C7130	Gallbladder_Papillomatosis	Gallbladder_Neoplasm|Papillomatosis	Gallbladder Papillomatosis
C7131	Benign_Gallbladder_Granular_Cell_Tumor	Benign_Granular_Cell_Tumor|Benign_Non-Epithelial_Gallbladder_Neoplasm	Benign Gallbladder Granular Cell Tumor|Benign Gallbladder Granular Cell Neoplasm
C7132	Glandular_Cell_Neoplasm	Epithelial_Neoplasm	Glandular Cell Neoplasm|Glandular Cell Epithelial Neoplasm|Glandular Cell Epithelium Neoplasm
C7133	Tubular_Androblastoma-Sertoli_Cell_Tumor	Ovarian_Sertoli-Stromal_Cell_Tumor|Sertoli_Cell_Tumor	Ovarian Sertoli Cell Tumor
C7134	Bone_Surface_Peripheral_Osteosarcoma	Primary_Bone_Osteosarcoma	Bone Surface (Peripheral) Osteosarcoma|Peripheral Osteosarcoma|Surface Osteosarcoma
C7135	Extraosseous_Ewing_s_Sarcoma	Ewing_s_Sarcoma|Extraosseous_Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor	Extraosseous Ewing's Sarcoma|EOE|Extra-Osseous Ewing's Sarcoma|Extraosseous Ewing's Tumor|Extraskeletal Ewing's Sarcoma	This is a rare malignant neoplasm of the soft tissue.  It is typically a disease of children and young adults.  Characterized by t(11:22) (q24: q12) cytogenic abnormality expressing EWS/FLI-1 chimeric transcript.  Most commonly occurs in the paravertebral region, chest wall, pelvis and lower extremities.  Treatment includes local excision with consideration for post operative chemotherapy and/or radiotherapy. - 2003
C7136	Extracutaneous_Mastocytoma	Mastocytoma|Systemic_Mastocytosis	Extracutaneous Mastocytoma	A localized tumor consisting of mature mast cells. (WHO, 2001) -- 2003
C7137	Cutaneous_Mastocytosis	Cutaneous_Hematopoietic_and_Lymphoid_Cell_Neoplasm|Dermal_Neoplasm|Mast_Cell_Neoplasm	Cutaneous Mastocytosis|CM	A form of mastocytosis characterized by mast cell infiltration of the skin.  (WHO, 2001) -- 2003
C7138	Solitary_Mastocytoma_of_the_Skin	Benign_Mastocytoma|Pure_Cutaneous_Mastocytosis	Solitary Mastocytoma of the Skin|Cutaneous Solitary Mastocytoma|Skin Solitary Mastocytoma|Solitary Mastocytoma of Skin
C7139	PRETEXT_Stage_1_Hepatoblastoma	Hepatoblastoma	PRETEXT Stage 1 Hepatoblastoma	In internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves only 1 quadrant; 3 adjoining liver quadrants are free of tumor. (from PDQ 2004)
C7140	PRETEXT_Stage_2_Hepatoblastoma	Hepatoblastoma	PRETEXT Stage 2 Hepatoblastoma	In internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves 2 adjoining quadrants; 2 adjoining quadrants are free of tumor. (from PDQ 2004)
C7141	PRETEXT_Stage_3_Hepatoblastoma	Hepatoblastoma	PRETEXT Stage 3 Hepatoblastoma	In internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves 3 adjoining quadrants or 2 nonadjoining quadrants; 1 quadrant or 2 nonadjoining quadrants are free of tumor. (from PDQ 2004)
C7142	PRETEXT_Stage_4_Hepatoblastoma	Hepatoblastoma	PRETEXT Stage 4 Hepatoblastoma	In internationally developed presurgical anatomic staging system using imaging techniques: Tumor involves all 4 quadrants; there is no quadrant free of tumor. (from PDQ 2004)
C7143	Postsurgical_Stage_IV_Hepatoblastoma	Hepatoblastoma	Postsurgical Stage IV Hepatoblastoma	Distant metastases, regardless of the extent of liver involvement. (from PDQ 2004)
C7144	Postsurgical_Stage_III_Hepatoblastoma	Hepatoblastoma	Postsurgical Stage III Hepatoblastoma	No distant metastases, tumor unresectable or resected with gross residual tumor, or positive lymph nodes. (from PDQ 2004)
C7145	Postsurgical_Stage_II_Hepatoblastoma	Hepatoblastoma	Postsurgical Stage II Hepatoblastoma	No metastases, tumor grossly resected with microscopic residual disease (i.e., positive margins); or tumor rupture, or tumor spill at the time of surgery. (from PDQ 2004)
C7146	Postsurgical_Stage_I_Hepatoblastoma	Hepatoblastoma	Postsurgical Stage I Hepatoblastoma	No metastases, tumor completely resected. (from PDQ 2004)
C7147	Benign_Fibrous_Soft_Tissue_Neoplasm	Benign_Soft_Tissue_Neoplasm|Fibrocytic_Neoplasm	Benign Fibrocytic Neoplasm|Benign Fibrous Neoplasm of Soft Tissue|Benign Fibrous Neoplasm of the Soft Tissue|Benign Fibrous Soft Tissue Neoplasm|Benign Fibrous Soft Tissue Tumor|Benign Fibrous Tumor of Soft Tissue|Benign Fibrous Tumor of the Soft Tissue
C7148	Miscellaneous_Mesenchymal_Neoplasm	Mesenchymal_Cell_Neoplasm	Miscellaneous Mesenchymal Neoplasm
C7149	Smoldering_Myeloma	Plasma_Cell_Myeloma	Smoldering Myeloma
C7150	Indolent_Myeloma	Plasma_Cell_Myeloma	Indolent Myeloma
C7151	Monoclonal_Immunoglobulin_Deposition_Disease	Plasma_Cell_Neoplasm	Monoclonal Immunoglobulin Deposition Disease|Immunoglobulin Deposition Disease
C7152	Erythroleukemia	Acute_Erythroid_Leukemia	Erythroleukemia|M6a|erythroleukemia	Acute erythroid leukemia characterised by the presence of at least 50% erythroid precursors and at least 20% myeloblasts in the bone marrow. -- 2003
C7153	Well-differentiated_Thyroid_Carcinoma	Thyroid_Adenocarcinoma	Differentiated Thyroid Gland Carcinoma|Differentiated Thyroid Cancer|Differentiated Thyroid Carcinoma|Thyroid Gland Differentiated Carcinoma|Thyroid Gland Well Differentiated Carcinoma|Well Differentiated Thyroid Carcinoma|Well Differentiated Thyroid Gland Carcinoma|Well-differentiated Thyroid Cancer	An adenocarcinoma arising from the thyroid gland showing extensive evidence of follicular cell differentiation.  According to the nuclear features of the malignant follicular cells, it is classified either as papillary, or follicular carcinoma. (NCI05)
C7154	Bone_Leiomyosarcoma	Bone_Sarcoma|Leiomyosarcoma	Bone Leiomyosarcoma|Leiomyosarcoma of Bone
C7155	Primary_Bone_Chondrosarcoma	Bone_Sarcoma|Chondrosarcoma	Primary Bone Chondrosarcoma|Primary Chondrosarcoma of Bone|Primary Chondrosarcoma of the Bone
C7157	Neurohypophysis_Neoplasm	Pituitary_Gland_Neoplasm	Posterior Pituitary Gland Neoplasm|Neurohypophysis Neoplasm|Neurohypophysis Tumor|Posterior Pituitary Gland Tumor|Posterior Pituitary Neoplasm|Posterior Pituitary Tumor	A neoplasm arising from pituicytes in the posterior lobe of the pituitary gland. (NCI05)
C7158	Benign_Dermal_Neoplasm	Benign_Skin_Neoplasm|Dermal_Neoplasm	Benign Dermal Neoplasm
C7159	Subepidermal_Nodular_Fibrosis	Benign_Cutaneous_Fibrohistiocytic_Neoplasm	Subepidermal Nodular Fibrosis
C7160	Sclerosing_Hemangioma	Retired_Concepts	Sclerosing Hemangioma
C7161	Melanocytic_Skin_Neoplasm	Melanocytic_Neoplasm|Skin_Neoplasm	Melanocytic Skin Neoplasm|Cutaneous Melanocytic Neoplasm|Melanocytic Neoplasm of Skin
C7162	Cutaneous_Lymphoma	Cutaneous_Hematopoietic_and_Lymphoid_Cell_Neoplasm|Cutaneous_Lymphoproliferative_Disorder|Lymphoma_by_Site|Malignant_Skin_Neoplasm	Cutaneous Lymphoma|Primary Cutaneous Lymphoma|Skin Lymphoma
C7164	Classical_Hodgkin_s_Lymphoma	Hodgkin_s_Lymphoma	Classical Hodgkin's Lymphoma|Classical Hodgkin Lymphoma|cHL	In more than 95% of cases, a monoclonal B-cell lymphoproliferation characterized by a bimodal age distribution (15-30 years of life and late life), often associated with EBV infection.  In less than 5% of cases, this is a monoclonal proliferation of T-lymphocytes. Morphologically, it is characterized by the presense of Reed-Sternberg cells and mononuclear Hodgkin cells.  The Reed-Sternberg and mononuclear Hodgkin cells are CD30 positive in nearly all cases and CD15 positive in the majority of cases.  -- 2004
C7165	Grade_1_Nodular_Sclerosis_Hodgkin_s_Lymphoma	Nodular_Sclerosis_Hodgkin_s_Lymphoma	Grade 1 Nodular Sclerosis Hodgkin's Lymphoma|Grade I Nodular Sclerosis Hodgkin's Lymphoma
C7166	Grade_2_Nodular_Sclerosis_Hodgkin_s_Lymphoma	Nodular_Sclerosis_Hodgkin_s_Lymphoma	Grade 2 Nodular Sclerosis Hodgkin's Lymphoma|Grade II Nodular Sclerosis Hodgkin's Lymphoma
C7167	RAEB-1	Refractory_Anemia_with_Excess_Blasts	RAEB-1|RAEB-I	A myelodysplastic syndrome defined by 5-9% blasts in the bone marrow, and <5% blasts in the blood.  Approximately 25% of cases progress to an acute leukemia.  (WHO, 2001) -- 2003
C7168	RAEB-2	Refractory_Anemia_with_Excess_Blasts	RAEB-2|RAEB-II	A myelodysplastic syndrome defined by 10-19% blasts in the bone marrow or 5-19% blasts in the blood and <10% blasts in the bone marrow.  Approximately 33% of cases progress to acute leukemia.  The prognosis is usually poor.  (WHO, 2001) -- 2003
C7169	Pineal_Region_Dysgerminoma	Dysgerminoma|Malignant_Pineal_Region_Germ_Cell_Neoplasm	Pineal Region Dysgerminoma|Pineal Dysgerminoma
C7170	Acute_Monocytic_Leukemia	Retired_Concepts	Acute Monocytic Leukemia|Acute Monocytic Leukemia (FAB M5b)
C7171	Acute_Monoblastic_Leukemia	Acute_Monoblastic_Leukemia_and_Acute_Monocytic_Leukemia	Acute Monoblastic Leukemia|Acute Monoblastic Leukemia (FAB M5a)	An acute myeloid leukemia in which the monoblasts represent 80% or more of the total cellular population.  (WHO, 2001) -- 2003
C7172	Central_Nervous_System_Neuroepithelial_Neoplasm_of_Uncertain_Origin	Central_Nervous_System_Neoplasm|Neoplasm_of_Uncertain_Histogenesis|Neuroepithelial_Neoplasm	Central Nervous System Neuroepithelial Neoplasm of Uncertain Origin
C7173	Diffuse_Astrocytoma	Astrocytic_Tumor	Diffuse Astrocytoma|Diffuse Astrocytic Neoplasm|Diffuse Astrocytic Tumor|Grade II Astrocytic Neoplasm|Grade II Astrocytic Tumor|Grade II Astrocytoma|WHO Grade II Astrocytoma	Diffuse Astrocytoma is a low-grade (WHO grade II) astrocytic neoplasm, previously called 'astrocytoma'.  It is characterized by a high degree of cellular differentiation, slow growth, and diffuse infiltration of neighboring brain structures. These lesions typically affect young adults and have an intrinsic tendency for malignant progression to anaplastic astrocytoma and, ultimately, glioblastoma. According to the prevailing cells type, three major variants can be distinguished: Fibrillary Astrocytoma, Gemistocytic Astrocytoma, and Protoplasmic Astrocytoma. (Adapted from WHO)
C7174	Adult_Diffuse_Astrocytoma	Adult_Astrocytic_Tumor|Diffuse_Astrocytoma	Adult Diffuse Astrocytoma|WHO Grade II Astrocytoma
C7175	Acute_Myeloid_Leukemia_with_Recurrent_Genetic_Abnormalities	Acute_Myeloid_Leukemia	Acute Myeloid Leukemia with Recurrent Genetic Abnormalities	A group of acute myeloid leukemias (AMLs) characterized by recurrent genetic abnormalities, mainly balanced translocations.  This group of AMLs often has a high rate of complete remission, and favorable prognosis.  (WHO, 2001) -- 2003
C7176	Aleukemic_Lymphocytic_Leukemia	Aleukemic_Lymphoid_Leukemia|Chronic_Lymphocytic_Leukemia	Aleukemic Lymphocytic Leukemia
C7177	Aleukemic_Lymphoblastic_Leukemia	Acute_Lymphoblastic_Leukemia|Aleukemic_Lymphoid_Leukemia	Aleukemic Lymphoblastic Leukemia
C7178	Smoldering_Adult_T-Cell_Lymphoma_Leukemia	Adult_T-Cell_Lymphoma_Leukemia|Leukemic_Phase_of_Lymphoma	Smoldering Adult T-Cell Lymphoma/Leukemia	An adult T-cell lymphoma/leukemia characterized by less than 5% neoplastic lymphocytes in the peripheral blood, absence of lymphadenopathy and hypercalcemia, and occasional skin or pulmonary lesions. -- 2004
C7179	Chronic_Adult_T-Cell_Lymphoma_Leukemia	Adult_T-Cell_Lymphoma_Leukemia|Leukemic_Phase_of_Lymphoma	Chronic Adult T-Cell Lymphoma/Leukemia	An adult T-cell lymphoma/leukemia associated with skin lesions and mild lymphadenopathy.  Neoplastic lymphocytes are not numerous in the peripheral blood.  Hypercalcemia is absent. -- 2004
C7180	Spindle_Cell_Pleomorphic_Lipoma	Lipoma	Spindle Cell/Pleomorphic Lipoma	A benign lipomatous neoplasm.  The spindle cell and pleomorphic variants represent morphologically opposite ends of the same entity.
C7182	B-Cell_Proliferation_of_Uncertain_Malignant_Potential	Mature_B-Cell_Lymphocytic_Neoplasm|Neoplasm_of_Uncertain_Malignant_Potential|Premalignant_Hematologic_Condition	B-Cell Proliferation of Uncertain Malignant Potential
C7183	Polymorphic_Post-Transplant_Lymphoproliferative_Disorder	B-Cell_Proliferation_of_Uncertain_Malignant_Potential|Neoplastic_Post-Transplant_Lymphoproliferative_Disorder	Polymorphic Post-Transplant Lymphoproliferative Disorder|Polymorphic B-Cell Lymphoma|Polymorphic PTLD
C7184	Methotrexate-Associated_Lymphoproliferative_Disorder	Lymphoma	Methotrexate-Associated Lymphoproliferative Disorder|Methotrexate-Associated Lymphoproliferation	A lymphoproliferative disorder that develops in patients who are immunosuppressed with methotrexate.  This disorder is often Epstein-Barr virus positive, and morphologically it may resemble large B-cell non-Hodgkin's lymphoma, Hodgkin's lymphoma, or a polymorphous post-transplant lymphoproliferative disorder. (WHO, 2001) -- 2003
C7185	Lymphoma_by_Site	Lymphoma	Lymphoma by Site
C7186	Lymphoma_by_Working_Formulation_Antiquated	Hematopoietic_and_Lymphoid_Neoplasms_Antiquated	Lymphoma by Working Formulation (Antiquated)
C7187	Non-Burkitt_s_Lymphoma	Malignant_Lymphoma_Non-Cleaved_Cell_Type	Non-Burkitt's Lymphoma
C7188	Classical_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma	Classical Burkitt's Lymphoma
C7189	Burkitt_s_Lymphoma_with_Plasmacytoid_Differentiation	Burkitt_s_Lymphoma	Burkitt's Lymphoma with Plasmacytoid Differentiation|Burkitt Lymphoma with Plasmacytoid Differentiation
C7190	Malignant_Hypopharyngeal_Neoplasm	Hypopharyngeal_Neoplasm|Malignant_Pharyngeal_Neoplasm	Malignant Hypopharyngeal Neoplasm|Malignant Hypopharyngeal Tumor|Malignant Neoplasm of Hypopharynx|Malignant Neoplasm of the Hypopharynx|Malignant Tumor of Hypopharynx|Malignant Tumor of the Hypopharynx
C7191	Grade_3a_Follicular_Lymphoma	Grade_3_Follicular_Lymphoma	Grade 3a Follicular Lymphoma
C7192	Grade_3b_Follicular_Lymphoma	Grade_3_Follicular_Lymphoma	Grade 3b Follicular Lymphoma
C7194	Grade_2_Diffuse_Follicle_Center_Lymphoma	Diffuse_Follicle_Center_Lymphoma	Grade 2 Diffuse Follicle Centre Lymphoma
C7195	Primary_Cutaneous_CD30-Positive_T-Cell_Lymphoproliferative_Disorder	Cutaneous_Mature_T-Cell_and_NK-Cell_Neoplasm	Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder|Primary Cutaneous CD30+ T-Cell Lymphoproliferative Disorder	This entity represents a spectrum of lymphoproliferative disorders characterized by CD30 (Ki-1)-positive cutaneous T-cell infiltrates.  The two ends of the spectrum include lymphomatoid papulosis (benign end) and primary cutaneous anaplastic large cell lymphoma (malignant end).  Borderline lesions are also included in this spectrum.  (WHO, 2001) -- 2003
C7196	Borderline_Primary_Cutaneous_CD30-Positive_T-Cell_Lymphoproliferative_Disorder	Primary_Cutaneous_CD30-Positive_T-Cell_Lymphoproliferative_Disorder|T-Cell_Proliferation_of_Uncertain_Malignant_Potential	Borderline Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorder|Borderline Primary Cutaneous CD30+ T-Cell Lymphoproliferative Disorder
C7197	Type_A_Lymphomatoid_Papulosis	Lymphomatoid_Papulosis|Primary_Cutaneous_CD30-Positive_T-Cell_Lymphoproliferative_Disorder	Type A Lymphomatoid Papulosis|Type A LyP
C7198	Type_B_Lymphomatoid_Papulosis	Lymphomatoid_Papulosis	Type B Lymphomatoid Papulosis|Type B LyP
C7199	Diffuse_Large_Cell_Type_Lymphomatoid_Papulosis	Borderline_Primary_Cutaneous_CD30-Positive_T-Cell_Lymphoproliferative_Disorder|Lymphomatoid_Papulosis	Diffuse Large Cell Type Lymphomatoid Papulosis|Diffuse Large Cell Type LyP|Type C LyP|Type C Lymphomatoid Papulosis	A lymphomatoid papulosis characterized clinically by regressing skin papules, and morphologically by features resembling anaplastic large cell lymphoma. -- 2004
C7200	Anaplastic_Large_Cell_Lymphoma_Lymphomatoid_Papulosis-Like_Histology	Borderline_Primary_Cutaneous_CD30-Positive_T-Cell_Lymphoproliferative_Disorder	Anaplastic Large Cell Lymphoma, Lymphomatoid Papulosis-Like Histology
C7201	Infrequent_Neoplasm	Neoplasm_by_Special_Category	Infrequent Neoplasm|Infrequent Tumor
C7202	Malignant_Histiocytosis	Hematopoietic_and_Lymphoid_Neoplasms_Antiquated	Malignant Histiocytosis	An aggressive Non-Hodgkin's adult lymphoma, comprised of two clinical syndromes: nasal T-cell lymphoma (previously called lethal midline granuloma) and pulmonary angiocentric B-cell lymphoma (previously called lymphomatoid granulomatosis). (PDQ)
C7203	Blastic_NK-Cell_Lymphoma	Cutaneous_Hematopoietic_and_Lymphoid_Cell_Neoplasm|Malignant_Skin_Neoplasm	CD4+/CD56+ Hematodermic Neoplasm|Blastic NK-Cell Lymphoma|Early Plasmacytoid Dendritic Cell Leukemia/Lymphoma|Monomorphic NK-Cell Lymphoma|Primary Cutaneous CD4+/CD56+ Hematolymphoid Neoplasm	An aggressive immature hematologic neoplasm formerly known as blastic NK cell lymphoma, composed of cells with a lymphoblast-like morphology.  Recent evidence suggests derivation from a plasmacytoid dendritic cell precursor.  Patients present with cutaneous tumors and disseminated disease. -- 2005
C7204	T-Zone_Variant_Peripheral_T-Cell_Lymphoma	Unspecified_Peripheral_T-Cell_Lymphoma	T-Zone Variant Peripheral T-Cell Lymphoma|T-Zone Lymphoma
C7205	Lymphoepithelioid_Cell_Variant_Peripheral_T-Cell_Lymphoma	Unspecified_Peripheral_T-Cell_Lymphoma	Lymphoepithelioid Cell Variant Peripheral T-Cell Lymphoma|Lennert Lymphoma|Lennert Variant Peripheral T-Cell Lymphoma|Lennert's Lymphoma|Lennert's Variant Peripheral T-Cell Lymphoma
C7206	Common_Variant_Anaplastic_Large_Cell_Lymphoma	Anaplastic_Large_Cell_Lymphoma	Common Variant Anaplastic Large Cell Lymphoma
C7207	Lymphohistiocytic_Variant_Anaplastic_Large_Cell_Lymphoma	Anaplastic_Large_Cell_Lymphoma	Lymphohistiocytic Variant Anaplastic Large Cell Lymphoma
C7208	Small_Cell_Variant_Anaplastic_Large_Cell_Lymphoma	Anaplastic_Large_Cell_Lymphoma	Small Cell Variant Anaplastic Large Cell Lymphoma
C7209	Childhood_Precursor_B_Lymphoblastic_Lymphoma	Childhood_Lymphoblastic_Lymphoma|Precursor_B_Lymphoblastic_Lymphoma	Childhood Precursor B-Lymphoblastic Lymphoma
C7210	Childhood_Precursor_T_Lymphoblastic_Lymphoma	Childhood_Lymphoblastic_Lymphoma|Childhood_Precursor_T-Lymphoblastic_Lymphoma_Leukemia|Precursor_T_Lymphoblastic_Lymphoma	Childhood Precursor T-Lymphoblastic Lymphoma
C7211	Childhood_Primary_Cutaneous_Anaplastic_Large_Cell_Lymphoma	Childhood_Anaplastic_Large_Cell_Lymphoma|Primary_Cutaneous_Anaplastic_Large_Cell_Lymphoma	Childhood Primary Cutaneous Anaplastic Large Cell Lymphoma|Childhood Primary Cutaneous CD30+ Anaplastic Large Cell Lymphoma|Childhood Primary Cutaneous CD30-Positive Anaplastic Large Cell Lymphoma|Childhood Primary Cutaneous Ki-1 Positive Anaplastic Large Cell Lymphoma|Childhood Primary Cutaneous Ki-1+ Anaplastic Large Cell Lymphoma|Pediatric Primary Cutaneous Anaplastic Large Cell Lymphoma|Pediatric Primary Cutaneous CD30+ Anaplastic Large Cell Lymphoma|Pediatric Primary Cutaneous K-1+ Anaplastic Large Cell Lymphoma
C7212	AIDS-Related_Diffuse_Large_B-cell_Lymphoma	AIDS-Related_Non-Hodgkin_s_Lymphoma|Aggressive_Non-Hodgkin_s_Lymphoma|Diffuse_Large_B-Cell_Lymphoma	AIDS-Related Diffuse Large B-cell Lymphoma
C7213	AIDS-Related_Diffuse_Large_Cell_Lymphoma	AIDS-Related_Lymphoma_by_Working_Formulation|Diffuse_Malignant_Lymphoma|Malignant_Lymphoma_Large_Cell_Type	AIDS-Related Diffuse Large Cell Lymphoma|AIDS Associated Diffuse Large Cell Lymphoma|AIDS Related Diffuse Large Cell Lymphoma|AIDS-Associated Diffuse Large Cell Lymphoma
C7215	Non-Hodgkin_s_Lymphoma_by_Clinical_Course	Non-Hodgkin_s_Lymphoma	Non-Hodgkin's Lymphoma by Clinical Course
C7216	Non-Hodgkin_s_Lymphoma_with_Variable_Clinical_Course	Non-Hodgkin_s_Lymphoma_by_Clinical_Course	Non-Hodgkin's Lymphoma with Variable Clinical Course
C7217	Cutaneous_Follicle_Center_Lymphoma	Cutaneous_B-Cell_Lymphoma|Cutaneous_Follicular_Lymphoma|Indolent_Non-Hodgkin_s_Lymphoma	Primary Cutaneous Follicle Center Lymphoma|Cutaneous Follicle Center Lymphoma|Cutaneous Follicle Centre Lymphoma|PCFCL	A primary follicular lymphoma of the skin.  It presents with solitary or grouped plaques and tumors, and it usually involves the scalp, forehead, or trunk.  It rarely involves the legs.  This type of cutaneous lymphoma tends to remain localized to the skin, and it has a favorable prognosis.  Its morphologic pattern can be nodular, diffuse, or nodular and diffuse.  It is composed of various numbers of small and large irregular B-lymphocytes.
C7218	Cutaneous_Follicular_Lymphoma	Cutaneous_Mature_B-Cell_Neoplasm|Follicular_Lymphoma	Cutaneous Follicular Lymphoma	A follicular lymphoma involving the skin.  A cutaneous follicular lymphoma may be metastatic to the skin from the lymph nodes or other anatomic sites or primary (cutaneous follicle center lymphoma). --2003
C7219	Grade_2_Cutaneous_Follicular_Lymphoma	Cutaneous_Follicular_Lymphoma|Grade_2_Follicular_Lymphoma	Grade 2 Cutaneous Follicular Lymphoma
C7220	Grade_1_Cutaneous_Follicular_Lymphoma	Cutaneous_Follicular_Lymphoma|Grade_1_Follicular_Lymphoma	Grade 1 Cutaneous Follicular Lymphoma
C7221	Cutaneous_Hodgkin_s_Lymphoma	Cutaneous_Lymphoma|Hodgkin_s_Lymphoma	Cutaneous Hodgkin's Lymphoma|Cutaneous Hodgkin Lymphoma|Primary Cutaneous Hodgkin Disease|Primary Cutaneous Hodgkin Lymphoma|Primary Cutaneous Hodgkin's Disease|Primary Cutaneous Hodgkin's Lymphoma	Hodgkin's lymphoma primarily involving the skin.  This diagnosis can only be made when there is no evidence of Hodgkin's lymphoma in the lymph nodes or other anatomic sites.  Patients usually present with papules or nodular lesions.  Morphologically, primary cutaneous Hodgkin's lymphoma may resemble lymphomatoid papulosis or anaplastic large cell lymphoma.  Immunohistochemical tissue evaluation is essential in establishing the diagnosis. --2003
C7222	Hematopoietic_and_Lymphoid_Neoplasms_NEC	Retired_Concepts	Hematopoietic and Lymphoid Neoplasms NEC
C7223	Adult_Lymphocyte_Rich_Classical_Hodgkin_s_Lymphoma	Adult_Hodgkin_s_Lymphoma|Lymphocyte_Rich_Classical_Hodgkin_s_Lymphoma	Adult Lymphocyte Rich Classical Hodgkin's Lymphoma|Adult Lymphocyte Rich Classical Hodgkin Lymphoma|Adult Lymphocyte Rich Classical Hodgkin's Disease
C7224	Plasmablastic_Lymphoma	Diffuse_Large_B-Cell_Lymphoma	Plasmablastic Lymphoma
C7225	Diffuse_Large_B-Cell_Lymphoma_with_Expression_of_Full-Length_ALK	Diffuse_Large_B-Cell_Lymphoma	Diffuse Large B-Cell Lymphoma with Expression of Full-Length ALK|Diffuse Large B-Cell Lymphoma with Expression of Full-Length Anaplastic Lymphoma Kinase
C7226	Adult_Precursor_T_Lymphoblastic_Lymphoma	Adult_Lymphoblastic_Lymphoma|Precursor_T_Lymphoblastic_Lymphoma	Adult Precursor T-Lymphoblastic Lymphoma
C7227	Refractory_Precursor_T_Lymphoblastic_Lymphoma	Precursor_T_Lymphoblastic_Lymphoma|Refractory_Precursor_T_Lymphoblastic_Lymphoma_Leukemia|Refractory_T-Cell_Non-Hodgkin_s_Lymphoma	Refractory Precursor T-Lymphoblastic Lymphoma
C7228	Refractory_Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Mature_B-Cell_Non-Hodgkin_s_Lymphoma|Refractory_B-Cell_Non-Hodgkin_s_Lymphoma	Refractory Mature B-Cell Non-Hodgkin's Lymphoma|Refractory Mature B-Cell Lymphoma|Refractory Mature B-Cell Neoplasm|Refractory Mature B-Cell Non-Hodgkin Lymphoma
C7229	Blastoid_Variant_Mantle_Cell_Lymphoma	Mantle_Cell_Lymphoma	Blastoid Variant Mantle Cell Lymphoma
C7230	Cutaneous_Marginal_Zone_B_Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue	Cutaneous_B-Cell_Lymphoma|Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue	Primary Cutaneous Marginal Zone B Cell Lymphoma of Mucosa-Associated Lymphoid Tissue|C-MALT|Cutaneous Immunocytoma|Marginal Zone B Cell Lymphoma of Skin|Marginal Zone B Cell Lymphoma of the Skin|SALT Lymphoma|Skin-Associated Lymphoid Tissue Lymphoma
C7231	Small_Intestinal_Non-Hodgkin_s_Lymphoma	Gastrointestinal_Non-Hodgkin_s_Lymphoma|Small_Intestinal_Lymphoma	Small Intestinal Non-Hodgkin's Lymphoma|Primary Small Intestinal Non-Hodgkin's Lymphoma|Small Intestine Non-Hodgkin's Lymphoma
C7232	Neoplastic_Post-Transplant_Lymphoproliferative_Disorder	Lymphocytic_Neoplasm|Post-Transplant_Lymphoproliferative_Disorder	Neoplastic Post-Transplant Lymphoproliferative Disorder|Neoplastic PTLD|Post-Transplant Lymphocytic Neoplasm|Post-Transplant Lymphoproliferative Neoplasm|Post-Transplant Neoplastic Lymphoproliferative Disorder
C7233	Monomorphic_Post-Transplant_Lymphoproliferative_Disorder	Neoplastic_Post-Transplant_Lymphoproliferative_Disorder|Transplant-Related_Hematologic_Malignancy	Monomorphic Post-Transplant Lymphoproliferative Disorder|Monomorphic PTLD
C7234	Non-Neoplastic_Post-Transplant_Lymphoproliferative_Disorder	Post-Transplant_Lymphoproliferative_Disorder	Non-Neoplastic Post-Transplant Lymphoproliferative Disorder|Post-Transplant Lymphoproliferative Disorder Early Lesion
C7235	Plasmacytic_Hyperplasia_PTLD	Non-Neoplastic_Post-Transplant_Lymphoproliferative_Disorder	Plasmacytic Hyperplasia Post-Transplant Lymphoproliferative Disorder|Plasmacytic Hyperplasia PTLD
C7236	Infectious-Mononucleosis-Like_PTLD	Non-Neoplastic_Post-Transplant_Lymphoproliferative_Disorder	Infectious Mononucleosis-Like Post-Transplant Lymphoproliferative Disorder|Infectious Mononucleosis-like PTLD
C7237	Monomorphic_B-Cell_PTLD	Monomorphic_Post-Transplant_Lymphoproliferative_Disorder	Monomorphic B-Cell Post-Transplant Lymphoproliferative Disorder|Monomorphic B-Cell PTLD
C7238	Monomorphic_T-Cell_PTLD	Monomorphic_Post-Transplant_Lymphoproliferative_Disorder	Monomorphic T-Cell Post-Transplant Lymphoproliferative Disorder|Monomorphic T-Cell PTLD
C7239	Hodgkin_s-Like_PTLD	Epstein-Barr_Virus-Related_Clonal_Post-Transplant_Lymphoproliferative_Disorder	Hodgkin's-Like Post-Transplant Lymphoproliferative Disorder|Hodgkin's-like PTLD|Hodgkin-like PTLD
C7240	Plasma_Cell_PTLD	Monomorphic_B-Cell_PTLD|Plasma_Cell_Neoplasm	Plasma Cell Post-Transplant Lymphoproliferative Disorder|Plasma Cell PTLD
C7241	Plasmacytoma-Like_PTLD	Plasma_Cell_PTLD	Plasmacytoma-Like Post-Transplant Lymphoproliferative Disorder|Plasmacytoma-like PTLD
C7242	Plasma_Cell_Myeloma_PTLD	Plasma_Cell_Myeloma|Plasma_Cell_PTLD	Plasma Cell Myeloma Post-Transplant Lymphoproliferative Disorder|Plasma Cell Myeloma PTLD
C7243	Hodgkin_s_Lymphoma_PTLD	Epstein-Barr_Virus-Related_Clonal_Post-Transplant_Lymphoproliferative_Disorder|Epstein-Barr_Virus-Related_Hodgkin_s_Lymphoma	Hodgkin's Lymphoma Post-Transplant Lymphoproliferative Disorder|Hodgkin Lymphoma PTLD|Hodgkin's Lymphoma PTLD
C7244	Burkitt_s_Lymphoma_PTLD	Immunodeficiency-Related_Burkitt_s_Lymphoma|Monomorphic_B-Cell_PTLD	Burkitt's Lymphoma Post-Transplant Lymphoproliferative Disorder|Burkitt Lymphoma PTLD|Burkitt's Lymphoma PTLD
C7245	Burkitt_s-Like_Lymphoma_PTLD	Atypical_Burkitt_s_Burkitt_s-Like_Lymphoma|Burkitt_s_Lymphoma_PTLD	Burkitt's-Like Lymphoma Post-Transplant Lymphoproliferative Disorder|Burkitt's-like Lymphoma PTLD|Burkitt-like Lymphoma PTLD
C7246	Diffuse_Large_B-Cell_Lymphoma_PTLD	Aggressive_Non-Hodgkin_s_Lymphoma|Diffuse_Large_B-Cell_Lymphoma|Monomorphic_B-Cell_PTLD	Diffuse Large B-Cell Lymphoma Post-Transplant Lymphoproliferative Disorder|Diffuse Large B-Cell Lymphoma PTLD
C7247	Anaplastic_Lymphoma_PTLD	Anaplastic_Lymphoma|Diffuse_Large_B-Cell_Lymphoma_PTLD	Anaplastic Lymphoma Post-Transplant Lymphoproliferative Disorder|Anaplastic Diffuse Large B-Cell Lymphoma PTLD|Anaplastic Lymphoma PTLD
C7248	Centroblastic_Lymphoma_PTLD	Centroblastic_Lymphoma|Diffuse_Large_B-Cell_Lymphoma_PTLD	Centroblastic Lymphoma Post-Transplant Lymphoproliferative Disorder|Centroblastic Diffuse Large B-Cell Lymphoma PTLD|Centroblastic Lymphoma PTLD
C7249	Immunoblastic_Lymphoma_PTLD	Diffuse_Large_B-Cell_Lymphoma_PTLD|Immunoblastic_Lymphoma	Immunoblastic Lymphoma Post-Transplant Lymphoproliferative Disorder|Immunoblastic Diffuse Large B-Cell Lymphoma PTLD|Immunoblastic Lymphoma PTLD
C7251	Malignant_Testicular_Neoplasm	Malignant_Male_Reproductive_System_Neoplasm|Testicular_Neoplasm	Malignant Testicular Neoplasm|Malignant Neoplasm of Testis|Malignant Neoplasm of the Testis|Malignant Testicular Tumor|Malignant Tumor of Testis|Malignant Tumor of the Testis	A primary or metastatic malignant neoplasm involvingf the testis
C7252	Methotrexate-Associated_Peripheral_T-Cell_Lymphoma	Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma|Methotrexate-Associated_Lymphoproliferative_Disorder	Methotrexate-Associated Peripheral T-Cell Lymphoma
C7253	Methotrexate-Associated_Diffuse_Large_B-Cell_Lymphoma	Diffuse_Large_B-Cell_Lymphoma|Methotrexate-Associated_Lymphoproliferative_Disorder	Methotrexate-Associated Diffuse Large B-Cell Lymphoma
C7254	Methotrexate-Associated_Follicular_Lymphoma	Follicular_Lymphoma|Methotrexate-Associated_Lymphoproliferative_Disorder	Methotrexate-Associated Follicular Lymphoma
C7255	Methotrexate-Associated_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma|Methotrexate-Associated_Lymphoproliferative_Disorder	Methotrexate-Associated Burkitt's Lymphoma
C7256	Methotrexate-Associated_Hodgkin_s_Lymphoma	Hodgkin_s_Lymphoma|Methotrexate-Associated_Lymphoproliferative_Disorder	Methotrexate-Associated Hodgkin's Lymphoma
C7258	Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma	Hodgkin_s_Lymphoma	Nodular Lymphocyte Predominant Hodgkin's Lymphoma|NLPHL|Nodular Lymphocyte Predominant Hodgkin Lymphoma|Nodular Lymphocyte Predominant Hodgkins Disease|Nodular Lymphocyte Predominant Hodgkins Lymphoma	A monoclonal B-cell neoplasm characterized by a nodular, or a nodular and diffuse, polymorphous proliferation of scattered large neoplastic cells known as popcorn or L&H cells; the L&H cells are CD15 negative, and rarely positive for CD30 antigen.  Patients are predominantly male, frequently in the 30-50 year age group.  Most patients present with limited stage disease (localized peripheral lymphadenopathy, stage I or II); the prognosis of patients with stage I and stage II disease is very good.  Advanced stages have an unfavorable prognosis.  -- 2004
C7259	Recurrent_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma	Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma|Recurrent_Hodgkin_s_Lymphoma	Recurrent Nodular Lymphocyte Predominant Hodgkin's Lymphoma|Recurrent Nodular Lymphocyte Predominant Hodgkin's Disease|Relapsed Nodular Lymphocyte Predominant Hodgkin Lymphoma|Relapsed Nodular Lymphocyte Predominant Hodgkin's Disease|Relapsed Nodular Lymphocyte Predominant Hodgkin's Lymphoma
C7260	Refractory_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma	Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma|Refractory_Hodgkin_s_Lymphoma	Refractory Nodular Lymphocyte Predominant Hodgkin's Lymphoma|Refractory Nodular Lymphocyte Predominant Hodgkin's Disease
C7261	Stage_IV_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma	Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma|Stage_IV_Hodgkin_s_Lymphoma	Stage IV Nodular Lymphocyte Predominant Hodgkin's Lymphoma|Stage IV Nodular Lymphocyte Predominant Hodgkin's Disease	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C7262	Stage_III_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma	Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma|Stage_III_Hodgkin_s_Lymphoma	Stage III Nodular Lymphocyte Predominant Hodgkin's Lymphoma|Stage III Nodular Lymphocyte Predominant Hodgkin Lymphoma|Stage III Nodular Lymphocyte Predominant Hodgkin's Disease	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C7263	Thyroid_Immunoblastic_Lymphoma	Immunoblastic_Lymphoma|Thyroid_Diffuse_Large_B-Cell_Lymphoma	Thyroid Gland Immunoblastic Lymphoma|Immunoblastic Lymphoma of Thyroid|Immunoblastic Lymphoma of Thyroid Gland|Immunoblastic Lymphoma of the Thyroid|Immunoblastic Lymphoma of the Thyroid Gland|Primary Thyroid Gland Immunoblastic Lymphoma|Thyroid Immunoblastic Lymphoma	A diffuse large B-cell lymphoma variant, primarily involving the thyroid gland.  It is composed predominantly of immunoblasts. (NCI05)
C7264	Diffuse_Follicle_Center_Lymphoma	Follicular_Lymphoma|Indolent_Non-Hodgkin_s_Lymphoma	Diffuse Follicle Centre Lymphoma|Follicle Centre Lymphoma Diffuse
C7265	Angioimmunoblastic_Lymphadenopathy	Hematopoietic_and_Lymphoid_Neoplasms_Antiquated	Angioimmunoblastic Lymphadenopathy|AILD	An aggressive Non-Hodgkin's adult lymphoma, formerly called angioimmunoblastic lymphadenopathy with dysproteinemia (AILD). Characterized by clonal T-cell receptor gene rearrangement.  Frequent opportunistic infections due to an underlying immunodeficiency. (PDQ)
C7266	Basaloid_Lung_Carcinoma	Basaloid_Carcinoma|Large_Cell_Lung_Carcinoma	Basaloid Lung Carcinoma	A morphologic variant of large cell lung carcinoma characterized by the presence of a solid nodular or anastomotic trabecular growth pattern, peripherial palasading, and comedo type necrosis. (NCI05)
C7267	Combined_Large_Cell_Neuroendocrine_Carcinoma_of_the_Lung	Combined_Lung_Carcinoma|Large_Cell_Neuroendocrine_Lung_Carcinoma	Combined Large Cell Lung Neuroendocrine Carcinoma|Combined Large Cell Neuroendocrine Carcinoma of Lung|Combined Large Cell Neuroendocrine Carcinoma of the Lung|Pulmonary Combined Large Cell Neuroendocrine Carcinoma	A subtype of large cell neuroendocrine lung carcinoma characterized by the presence of large neuroendocrine cells in combination with adenocarcinoma, squamous cell carcinoma, giant cell carcinoma and/ or spindle cell carcinoma. (NCI05)
C7268	Mucinous_Bronchiolo-Alveolar_Lung_Carcinoma	Bronchiolo-Alveolar_Lung_Carcinoma	Mucinous Bronchioloalveolar Carcinoma|Mucinous Bronchioloalveolar Lung Carcinoma|Mucinous Bronchoalveolar Lung Carcinoma	A morphologic variant of bronchiolo-alveolar lung carcinoma characterized by tall columnar cells and mucin production. (NCI05)
C7269	Non-Mucinous_Bronchiolo-Alveolar_Lung_Carcinoma	Bronchiolo-Alveolar_Lung_Carcinoma	Non-Mucinous Bronchioloalveolar Carcinoma|Non-Mucinous Bronchioloalveolar Lung Carcinoma|Non-Mucinous Bronchoalveolar Lung Carcinoma	A morphologic variant of bronchiolo-alveolar lung carcinoma characterized by the presence of Clara cells and/or type II cells. (NCI05)
C7270	Mixed_Mucinous_and_Non-Mucinous_Bronchiolo-Alveolar_Lung_Carcinoma	Bronchiolo-Alveolar_Lung_Carcinoma	Mixed Mucinous and Non-Mucinous Bronchioloalveolar Carcinoma|Indeterminate Bronchioloalveolar Carcinoma|Mixed Mucinous and Non-Mucinous Bronchioloalveolar Lung Carcinoma|Mixed Mucinous and Non-Mucinous Bronchoalveolar Lung Carcinoma	A rare morphologic variant of bronchiolo-alveolar lung carcinoma characterized by the presence of both mucin and non-mucin producing cells. (NCI05)
C7271	Borderline_Ovarian_Serous_Cystic_Tumor	Borderline_Ovarian_Serous_Neoplasm	Borderline Ovarian Serous Papillary Cystic Tumor
C7278	Ovarian_Papillary_Cystadenoma	Ovarian_Papillary_Neoplasm|Ovarian_Serous_Cystadenoma	Ovarian Papillary Cystadenoma
C7279	Ovarian_Surface_Papilloma	Benign_Ovarian_Serous_Neoplasm|Ovarian_Papillary_Neoplasm|Papilloma	Ovarian Surface Papilloma
C7280	Ovarian_Transitional_Cell_Neoplasm	Ovarian_Epithelial_Neoplasm|Transitional_Cell_Neoplasm	Ovarian Transitional Cell Tumor|Ovarian Transitional Cell Neoplasm
C7281	Borderline_Ovarian_Mixed_Epithelial_Neoplasm	Borderline_Ovarian_Epithelial_Neoplasm|Ovarian_Mixed_Epithelial_Neoplasm	Borderline Ovarian Mixed Epithelial Tumor|Borderline Ovarian Mixed Epithelial Neoplasm|Mixed Ovarian Epithelial Neoplasm of Borderline Malignancy
C7282	Benign_Ovarian_Mixed_Epithelial_Neoplasm	Benign_Ovarian_Epithelial_Neoplasm|Ovarian_Mixed_Epithelial_Neoplasm	Benign Ovarian Mixed Epithelial Tumor|Benign Ovarian Mixed Epithelial Neoplasm
C7283	Ovarian_Cystic_Teratoma	Cystic_Teratoma|Mature_Ovarian_Teratoma	Ovarian Cystic Teratoma
C7284	Ovarian_Dermoid_Cyst_with_Secondary_Tumor	Ovarian_Monodermal_Teratoma|Teratoma_with_Malignant_Transformation	Ovarian Dermoid Cyst with Secondary Tumor
C7285	Ovarian_Solid_Teratoma	Mature_Ovarian_Teratoma	Ovarian Solid Teratoma
C7286	Ovarian_Monodermal_Teratoma	Ovarian_Teratoma	Ovarian Monodermal Teratoma|Monodermal Teratoma
C7287	Ovarian_Granulosa-Stromal_Cell_Tumor	Ovarian_Sex_Cord-Stromal_Tumor	Ovarian Granulosa-Stromal Cell Tumor
C7288	Adult_Type_Ovarian_Granulosa_Cell_Tumor	Ovarian_Granulosa_Cell_Tumor	Adult Type Ovarian Granulosa Cell Tumor
C7289	Juvenile_Type_Ovarian_Granulosa_Cell_Tumor	Juvenile_Granulosa_Cell_Tumor|Ovarian_Granulosa_Cell_Tumor	Juvenile Type Ovarian Granulosa Cell Tumor
C7290	Thecoma-Fibroma_Group_Ovarian_Tumor	Ovarian_Granulosa-Stromal_Cell_Tumor|Tumor_of_the_Thecoma_Fibroma_Group	Ovarian Tumor of the Thecoma/Fibroma Group|Thecoma/Fibroma Group Ovarian Tumor
C7291	Ovarian_Cellular_Fibroma	Cellular_Fibroma|Ovarian_Fibroma	Ovarian Cellular Fibroma
C7292	Malignant_Splenic_Soft_Tissue_Tumor	Malignant_Splenic_Neoplasm	Malignant Splenic Soft Tissue Tumor|Malignant Soft Tissue Neoplasm of Spleen|Malignant Soft Tissue Neoplasm of the Spleen|Malignant Soft Tissue Tumor of Spleen|Malignant Soft Tissue Tumor of the Spleen|Malignant Splenic Soft Tissue Neoplasm
C7294	Splenic_Non-Hodgkin_s_Lymphoma	Non-Hodgkin_s_Lymphoma|Splenic_Lymphoma	Splenic Non-Hodgkin's Lymphoma|Non-Hodgkin Lymphoma of Spleen|Non-Hodgkin Lymphoma of the Spleen|Non-Hodgkin's Lymphoma of Spleen|Non-Hodgkin's Lymphoma of the Spleen|Primary Splenic Non-Hodgkin's Lymphoma|Splenic Non-Hodgkin Lymphoma
C7295	Splenic_Hodgkin_s_Lymphoma	Hodgkin_s_Lymphoma|Splenic_Lymphoma	Splenic Hodgkin's Lymphoma|Hodgkin's Disease of Spleen|Hodgkin's Disease of the Spleen|Hodgkin's Lymphoma of Spleen|Hodgkin's Lymphoma of the Spleen|Primary Splenic Hodgkin's Lymphoma|Splenic Hodgkin Lymphoma|Splenic Hodgkin's Disease|Splenic Hodgkins Disease|Splenic Hodgkins Lymphoma
C7296	Splenic_Manifestation_of_Leukemia	Leukemia|Malignant_Splenic_Neoplasm	Splenic Manifestation of Leukemia
C7297	Splenic_Manifestation_of_Prolymphocytic_Leukemia	Prolymphocytic_Leukemia|Splenic_Manifestation_of_Leukemia	Splenic Manifestation of Prolymphocytic Leukemia
C7298	Splenic_Manifestation_of_T-Cell_Prolymphocytic_Leukemia	Splenic_Manifestation_of_Prolymphocytic_Leukemia|T-Cell_Prolymphocytic_Leukemia	Splenic Manifestation of T-Cell Prolymphocytic Leukemia
C7299	Splenic_Manifestation_of_B-Cell_Prolymphocytic_Leukemia	B-Cell_Prolymphocytic_Leukemia|Splenic_Manifestation_of_Prolymphocytic_Leukemia	Splenic Manifestation of B-Cell Prolymphocytic Leukemia
C7300	Splenic_Manifestation_of_Chronic_Lymphocytic_Leukemia	Chronic_Lymphocytic_Leukemia|Splenic_Manifestation_of_Leukemia	Splenic Manifestation of Chronic Lymphocytic Leukemia|Splenic Manifestation of CLL
C7301	Splenic_Manifestation_of_Hairy_Cell_Leukemia	Hairy_Cell_Leukemia|Splenic_Manifestation_of_Leukemia	Splenic Manifestation of Hairy Cell Leukemia
C7302	Splenic_Manifestation_of_T-Cell_Large_Granular_Lymphocyte_Leukemia	Splenic_Manifestation_of_Leukemia|T-Cell_Large_Granular_Lymphocyte_Leukemia	Splenic Manifestation of T-Cell Large Granular Lymphocyte Leukemia|Splenic Manifestation of LGL
C7303	Splenic_Manifestation_of_Chronic_Myelogenous_Leukemia	Chronic_Myelogenous_Leukemia|Splenic_Manifestation_of_Leukemia	Splenic Manifestation of Chronic Myelogenous Leukemia|Splenic Manifestation of CML
C7304	Splenic_Small_Lymphocytic_Lymphoma	Small_Lymphocytic_Lymphoma	Splenic Small Lymphocytic Lymphoma
C7305	Splenic_Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia	Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia	Splenic Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia
C7306	Splenic_Mantle_Cell_Lymphoma	Mantle_Cell_Lymphoma	Splenic Mantle Cell Lymphoma
C7307	Splenic_Follicular_Lymphoma	Follicular_Lymphoma|Splenic_Non-Hodgkin_s_Lymphoma	Splenic Follicular Lymphoma|Primary Splenic Follicular Lymphoma
C7308	Splenic_Diffuse_Large_B-Cell_Lymphoma	Diffuse_Large_B-Cell_Lymphoma|Splenic_Non-Hodgkin_s_Lymphoma	Splenic Diffuse Large B-Cell Lymphoma|Primary Splenic Diffuse Large B-Cell Lymphoma
C7309	Splenic_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma|Splenic_Non-Hodgkin_s_Lymphoma	Splenic Burkitt's Lymphoma|Primary Splenic Burkitt's Lymphoma
C7310	Splenic_Precursor_B_Lymphoblastic_Lymphoma	Precursor_B_Lymphoblastic_Lymphoma|Splenic_Precursor_Lymphoblastic_Lymphoma	Splenic Precursor B-Lymphoblastic Lymphoma
C7311	Splenic_Precursor_T_Lymphoblastic_Lymphoma	Precursor_T_Lymphoblastic_Lymphoma|Splenic_Precursor_Lymphoblastic_Lymphoma	Splenic Precursor T-Lymphoblastic Lymphoma
C7312	Splenic_Precursor_Lymphoblastic_Lymphoma	Precursor_Lymphoblastic_Lymphoma	Splenic Precursor Lymphoblastic Lymphoma
C7313	Benign_Ovarian_Serous_Neoplasm	Benign_Ovarian_Epithelial_Neoplasm|Ovarian_Serous_Neoplasm	Benign Ovarian Serous Tumor|Benign Ovarian Serous Neoplasm
C7315	Borderline_Ovarian_Serous_Papillary_Neoplasm	Borderline_Ovarian_Serous_Neoplasm|Ovarian_Papillary_Neoplasm	Borderline Ovarian Serous Surface Papillary Tumor|Borderline Ovarian Serous Surface Papillary Neoplasm
C7317	Ovarian_Mullerian_Adenosarcoma	Malignant_Ovarian_Endometrioid_Tumor|Mullerian_Adenosarcoma	Ovarian Adenosarcoma|Ovarian Mesodermal Adenosarcoma|Ovarian Mullerian Adenosarcoma
C7318	Acute_Monoblastic_Leukemia_and_Acute_Monocytic_Leukemia	Acute_Myeloid_Leukemia_not_Otherwise_Categorized	Acute Monoblastic Leukemia and Acute Monocytic Leukemia|Acute Myeloid Leukemia M5	Acute myeloid leukemia's (AMLs) in which 80% or more of the leukemic cells are of monocytic lineage.  Bleeding disorders are common presenting features.  These AMLs usually follow an aggressive clinical course.  (WHO, 2001) -- 2003
C7319	Adult_Acute_Monoblastic_Leukemia_and_Acute_Monocytic_Leukemia	Acute_Monoblastic_Leukemia_and_Acute_Monocytic_Leukemia|Adult_Acute_Myeloid_Leukemia	Adult Acute Monoblastic Leukemia and Acute Monocytic Leukemia|Adult Acute Monoblastic and Monocytic Leukemia (FAB M5)|Adult Acute Monoblastic and Monocytic Leukemia (M5)|M5 Adult Acute Monoblastic and Monocytic Leukemia
C7320	Childhood_Chronic_Myelogenous_Leukemia	Childhood_Leukemia|Chronic_Myelogenous_Leukemia	Childhood Chronic Myelogenous Leukemia|Childhood CML|Childhood Chronic Myeloid Leukemia
C7321	Ovarian_Mixed_Germ_Cell-Sex_Cord-Stromal_Tumor	Mixed_Germ_Cell-Sex_Cord-Stromal_Tumor|Ovarian_Neoplasm	Ovarian Mixed Germ Cell-Sex Cord-Stromal Tumor|Ovarian Mixed Germ Cell-Sex Cord Neoplasm|Ovarian Mixed Germ Cell-Sex Cord Tumor|Ovarian Mixed Germ Cell-Sex Cord-Stromal Neoplasm
C7322	Testicular_Mixed_Germ_Cell-Sex_Cord-Stromal_Tumor	Mixed_Germ_Cell-Sex_Cord-Stromal_Tumor|Testicular_Neoplasm	Testicular Mixed Germ Cell-Sex Cord-Stromal Tumor|Testicular Mixed Germ Cell-Sex Cord Neoplasm|Testicular Mixed Germ Cell-Sex Cord Tumor|Testicular Mixed Germ Cell-Sex Cord-Stromal Neoplasm
C7323	Stage_0_Seminoma	Seminoma	Stage 0 Seminoma
C7325	Stage_0_Testicular_Embryonal_Carcinoma	Stage_0_Testicular_Cancer|Testicular_Embryonal_Carcinoma	Stage 0 Testicular Embryonal Carcinoma|Intratubular Embryonal Carcinoma	Stage 0: pTis, N0, M0, S0.  pT0: No evidence of primary tumor (e.g., histologic scar in testis).  No regional lymph node metastasis.  M0: No distant metastasis. S0: Marker study levels within normal limits. (AJCC 6th ed.) - 2003
C7326	Testicular_Intratubular_Germ_Cell_Neoplasia_with_Extratubular_Extension	Stage_0_Testicular_Cancer	Testicular Intratubular Germ Cell Neoplasia with Extratubular Extension
C7327	Extragonadal_Seminoma	Malignant_Extragonadal_Germ_Cell_Tumor|Seminoma	Extragonadal Seminoma
C7328	Testicular_Seminoma	Common_Germ_Cell_Neoplasm|Malignant_Testicular_Germ_Cell_Tumor|Pure_Testicular_Germ_Cell_Tumor|Seminoma	Testicular Seminoma|Seminoma of Testis|Seminoma of the Testis|Testicular Seminoma Pure	This is a malignant tumor of the testis.  It is a type of germ cell tumor.  It is believed that it is derived from the sexually undifferentiated embryonic gonad.  The causes of germ cell tumors are unknown.  Treatment with radiotherapy is highly successful when the tumor is diagnosed in localized stages, which represents the majority of presentations of seminoma. -2002
C7329	Stage_0_Testicular_Seminoma	Stage_0_Seminoma|Stage_0_Testicular_Cancer|Testicular_Seminoma	Stage 0 Testicular Seminoma|Intratubular Seminoma|Stage 0 Seminoma of Testis|Stage 0 Seminoma of the Testis
C7330	Stage_I_Seminoma	Seminoma	Stage I Seminoma
C7331	Stage_II_Seminoma	Seminoma	Stage II Seminoma	Stage 2 includes anypT,N1-3,M0,SX.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension.
C7332	Stage_III_Seminoma	Seminoma	Stage III Seminoma	Stage 3 includes any T, any N, M1,SX.  M1: distant metastasis.
C7333	Intermediate_Fibrocytic_Neoplasm	Fibrocytic_Neoplasm|Intermediate_Soft_Tissue_Neoplasm	Intermediate Fibrocytic Neoplasm|Intermediate Fibrocytic Tumor
C7334	Intermediate_Vascular_Neoplasm	Intermediate_Soft_Tissue_Neoplasm|Vascular_Neoplasm	Intermediate Vascular Neoplasm|Intermediate Vascular Tumor
C7335	Reproductive_Endocrine_Neoplasm	Endocrine_Neoplasm|Gonadal_Disorder	Reproductive Endocrine Neoplasm|Reproductive System Endocrine Neoplasm
C7336	Nasal_Cavity_and_Paranasal_Sinus_Neoplasm	Head_and_Neck_Neoplasm|Nasal_Cavity_and_Paranasal_Sinus_Disorder	Nasal Cavity and Paranasal Sinus Neoplasm
C7337	Peritoneal_and_Retroperitoneal_Neoplasms	Neoplasm_by_Site|Peritoneal_and_Retroperitoneal_Disorder	Peritoneal and Retroperitoneal Neoplasms|Peritoneal and Retroperitoneal Tumors
C7338	Adult_Precursor_B_Lymphoblastic_Lymphoma	Adult_Lymphoblastic_Lymphoma|Precursor_B_Lymphoblastic_Lymphoma	Adult Precursor B-Lymphoblastic Lymphoma
C7339	Heavy_Chain_Deposition_Disease	Monoclonal_Immunoglobulin_Deposition_Disease	Heavy Chain Deposition Disease
C7340	Hematopoietic_and_Lymphoid_Neoplasms_Antiquated	Neoplasm_by_Obsolete_Classification	Hematopoietic and Lymphoid Neoplasms (Antiquated)|Blood Borne Cancer
C7341	Benign_Epithelial_Skin_Neoplasm	Benign_Skin_Neoplasm|Epithelial_Skin_Neoplasm	Benign Epithelial Skin Neoplasm|Benign Epithelial Skin Tumor|Benign Skin Epithelium Neoplasm|Benign Skin Epithelium Tumor
C7342	Epithelial_Skin_Neoplasm	Epithelial_Neoplasm|Skin_Neoplasm	Epithelial Skin Neoplasm|Epithelial Skin Tumor|Skin Epithelium Neoplasm|Skin Epithelium Tumor
C7343	Benign_Cutaneous_Fibrohistiocytic_Neoplasm	Benign_Dermal_Neoplasm|Benign_Fibrohistiocytic_Neoplasm|Cutaneous_Fibrohistiocytic_Neoplasm	Benign Cutaneous Fibrohistiocytic Neoplasm
C7344	Intermediate_Cutaneous_Fibrohistiocytic_Neoplasm	Cutaneous_Fibrohistiocytic_Neoplasm|Intermediate_Fibrohistiocytic_Neoplasm	Intermediate Cutaneous Fibrohistiocytic Neoplasm	This category includes intermediate fibrohistiocytic neoplasms that affect the dermis and the subcutaneous tissues. -- 2003
C7346	Cervical_Squamous_Intraepithelial_Neoplasia	Cervical_Intraepithelial_Neoplasia|Cervical_Squamous_Neoplasm|Squamous_Cell_Intraepithelial_Neoplasia	Cervical Squamous Intraepithelial Neoplasia|CIN|Cervical SIL|Cervical Squamous Intraepithelial Lesion|Cervix Squamous Intraepithelial Lesion|Cervix Uteri SIL|Cervix Uteri Squamous Intraepithelial Lesion|Squamous Intraepithelial Lesion of Cervix|Squamous Intraepithelial Lesion of Cervix Uteri|Squamous Intraepithelial Lesion of Uterine Cervix|Squamous Intraepithelial Lesion of the Cervix|Squamous Intraepithelial Lesion of the Cervix Uteri|Squamous Intraepithelial Lesion of the Uterine Cervix|Uterine Cervix SIL|Uterine Cervix Squamous Intraepithelial Lesion	(SER-vih-kul in-tra-eh-pih-THEEL-ee-ul NEE-o-play-zha) CIN. A general term for the growth of abnormal cells on the surface of the cervix. Numbers from 1 to 3 may be used to describe how much of the cervix contains abnormal cells.
C7347	Cervical_Squamous_Cell_Carcinoma_in_situ	High-Grade_Cervical_Squamous_Intraepithelial_Neoplasia|Stage_0_Cervical_Cancer|Stage_0_Squamous_Cell_Carcinoma	Cervical Squamous Cell Carcinoma In Situ|CIN 3|Cervical Squamous Intraepithelial Neoplasia 3|Cervix Squamous Cell Carcinoma in situ|Cervix Uteri Squamous Cell Carcinoma in situ|Severe Squamous Dysplasia of the Cervix|Squamous Cell Carcinoma in situ of Cervix|Squamous Cell Carcinoma in situ of Cervix Uteri|Squamous Cell Carcinoma in situ of Uterine Cervix|Squamous Cell Carcinoma in situ of the Cervix|Squamous Cell Carcinoma in situ of the Cervix Uteri|Squamous Cell Carcinoma in situ of the Uterine Cervix|Uterine Cervix Squamous Cell Carcinoma in situ	Staging is classification AJCC. Stage 0 includes Tis,NO,MO.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis.
C7348	High_Grade_Intraepithelial_Neoplasia	Intraepithelial_Neoplasia	High Grade Intraepithelial Neoplasia	This lesion shows moderate or marked architectural distortion with glandular crowding and prominent cellular atypia.  It includes moderate dysplasia and carcinoma in situ (severe dysplasia).  (WHO, 2000) -- 2003
C7351	Grade_II_Squamous_Intraepithelial_Neoplasia	Grade_II_Intraepithelial_Neoplasia|High-Grade_Squamous_Intraepithelial_Neoplasia	Grade II Squamous Intraepithelial Neoplasia|Grade 2 Squamous Intraepithelial Lesion|Grade 2 Squamous Intraepithelial Neoplasia|Grade II Squamous Intraepithelial Lesion
C7352	Retroperitoneal_Carcinoma	Carcinoma|Common_Carcinoma|Malignant_Retroperitoneal_Neoplasm	Retroperitoneal Carcinoma|Carcinoma of Retroperitoneum|Carcinoma of the Retroperitoneum
C7353	Retroperitoneal_Lymphoma	Lymphoma_by_Site|Malignant_Retroperitoneal_Neoplasm	Retroperitoneal Lymphoma|Primary Retroperitoneal Lymphoma
C7354	Benign_Peritoneal_Mesothelioma	Adenomatoid_Tumor|Benign_Peritoneal_Neoplasm|Peritoneal_Mesothelioma	Peritoneal Adenomatoid Tumor|Benign Peritoneal Mesothelioma
C7355	Renal_Pelvis_Transitional_Cell_Carcinoma	Renal_Pelvis_Carcinoma|Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter	Renal Pelvis Urothelial Carcinoma|Renal Pelvis Transitional Cell Carcinoma|Transitional Cell Carcinoma of Renal Pelvis|Transitional Cell Carcinoma of the Renal Pelvis|Urothelial Cell Carcinoma of Renal Pelvis|Urothelial Cell Carcinoma of the Renal Pelvis
C7356	Gallbladder_Adenosquamous_Carcinoma	Adenosquamous_Carcinoma|Gallbladder_Carcinoma	Gallbladder Adenosquamous Carcinoma|Adenosquamous Carcinoma of Gallbladder|Adenosquamous Carcinoma of the Gallbladder
C7357	Periosteal_Chondrosarcoma	Chondrosarcoma	Periosteal Chondrosarcoma
C7358	Juxtacortical_Chondrosarcoma	Chondrosarcoma	Juxtacortical Chondrosarcoma
C7359	Endometrial_Adenocarcinoma	Adenocarcinoma|Endometrial_Carcinoma	Endometrial Adenocarcinoma|Adenocarcinoma of Endometrium|Adenocarcinoma of the Endometrium	An adenocarcinoma arising from the uterine body cavity.  This is the most frequent malignant tumor affecting the uterine body, and is linked to estrogen therapy.  Most patients present with uterine bleeding and are over age 40 at the time of diagnosis.  The prognosis depends on the stage of the tumor, the depth of the uterine wall invasion, and the histologic subtype.  Endometrioid adenocarcinoma is the most frequently seen morphologic variant of endometrial adenocarcinoma. -- 2004
C7360	Grade_II_Prostatic_Intraepithelial_Neoplasia	Grade_II_Glandular_Intraepithelial_Neoplasia|High-Grade_Prostatic_Intraepithelial_Neoplasia	Grade II Prostatic Intraepithelial Neoplasia|Grade II PIN
C7361	Scrotal_Melanoma	Malignant_Scrotal_Neoplasm|Melanoma	Scrotal Melanoma|Melanoma of Scrotum|Melanoma of the Scrotum
C7362	Scirrhous_Carcinoma_of_the_Breast	Invasive_Breast_Carcinoma	Scirrhous Breast Carcinoma|Infiltrating Carcinoma of Breast with Fibrotic Stroma|Infiltrating Carcinoma of the Breast with Fibrotic Stroma|Scirrhous Carcinoma of Breast|Scirrhous Carcinoma of the Breast	An infiltrating breast carcinoma associated with stromal fibrosis. --2003
C7363	Intraductal_Papillomatosis	Papillomatosis	Intraductal Papillomatosis
C7364	Diffuse_Intraductal_Papillomatosis	Intraductal_Papillomatosis	Diffuse Intraductal Papillomatosis
C7365	Focal_Intraductal_Papillomatosis	Intraductal_Papillomatosis	Focal Intraductal Papillomatosis|Localized Intraductal Papillomatosis
C7367	Hair_Follicle_Neoplasm	Hair_Disorder|Skin_Appendage_Neoplasm	Hair Follicle Neoplasm|Hair Follicle Tumor|Hair Matrix Neoplasm|Hair Matrix Tumor|Neoplasm of Hair Follicle|Neoplasm of the Hair Follicle
C7368	Pilomatricoma	Benign_Germinative_Epithelium_Neoplasm	Pilomatrixoma|Benign Pilomatricoma|Benign Pilomatrixoma|Calcifying Epithelioma of Malherbe|Pilomatricoma
C7371	Paraurethral_Gland_Carcinoma	Malignant_Paraurethral_Gland_Neoplasm|Urethral_Carcinoma	Paraurethral Gland Carcinoma|Carcinoma of Paraurethral Gland|Carcinoma of the Paraurethral Gland	Abnormal malignant growth of cells in the paraurethral glands.
C7372	Cerebellar_Neuronal_and_Mixed_Neuronal-Glial_Tumor	Cerebellar_Neoplasm|Neuronal_and_Mixed_Neuronal-Glial_Tumor	Cerebellar Neuronal and Mixed Neuronal-Glial Tumor|Neuronal and Mixed Neuronal-Glial Tumor of Cerebellum
C7373	Nasopharyngeal_Nonkeratinizing_Carcinoma	Nasopharyngeal_Carcinoma	Nasopharyngeal Nonkeratinizing Carcinoma|Nasopharyngeal Non-Keratinizing Carcinoma	Nonkeratinizing nasopharyngeal carcinoma is defined as a carcinoma with cells at differing levels of maturation but lacking light microscopic evidence of squamous differentiation (Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999). --2002
C7374	Uterine_Gestational_Choriocarcinoma	Gestational_Choriocarcinoma|Uterine_Corpus_Choriocarcinoma	Uterine Corpus Gestational Choriocarcinoma|Gestational Uterine Corpus Choriocarcinoma
C7375	Pericardial_Fibroma	Retired_Concepts	Pericardial Fibroma
C7376	Malignant_Pleural_Mesothelioma	Malignant_Mesothelioma|Malignant_Pleural_Neoplasm|Pleural_Mesothelioma	Pleural Malignant Mesothelioma|Malignant Mesothelioma of Pleura|Malignant Mesothelioma of the Pleura|Malignant Pleural Mesothelioma
C7377	Malignant_Lung_Neoplasm	Lung_Neoplasm|Malignant_Respiratory_Tract_Neoplasm|Malignant_Thoracic_Neoplasm	Malignant Lung Neoplasm|Malignant Lung Tumor|Malignant Neoplasm of Lung|Malignant Neoplasm of the Lung|Malignant Tumor of Lung|Malignant Tumor of the Lung	A primary or metastatic malignant neoplasm involving the lung
C7378	Malignant_Prostate_Neoplasm	Malignant_Male_Reproductive_System_Neoplasm|Prostate_Neoplasm	Malignant Prostate Neoplasm|Malignant Neoplasm of Prostate|Malignant Neoplasm of the Prostate|Malignant Prostate Tumor|Malignant Tumor of Prostate|Malignant Tumor of the Prostate	A primary or metastatic malignant tumor involving the prostate gland.  The vast majority are carcinomas. -- 2003
C7379	Malignant_Anal_Neoplasm	Anal_Neoplasm|Malignant_Gastrointestinal_Neoplasm	Malignant Anal Neoplasm|Malignant Anal Tumor|Malignant Neoplasm of Anus|Malignant Neoplasm of the Anus|Malignant Tumor of Anus|Malignant Tumor of the Anus	Cancer relating to the anus.  Tumors of the anal margin (below the anal verge and involving the perianal hair-bearing skin) are classified with skin tumors.
C7380	Papillary_and_Follicular_Adenocarcinoma	Neoplasm_by_Obsolete_Classification	Thyroid Gland Papillary and Follicular Carcinoma|Papillary and Follicular Adenocarcinoma|Papillary and Follicular Carcinoma
C7381	Follicular_Variant_Papillary_Carcinoma	Papillary_Thyroid_Carcinoma	Follicular Variant Thyroid Gland Papillary Carcinoma|Follicular Variant Papillary Adenocarcinoma|Follicular Variant Papillary Carcinoma|Follicular Variant Papillary Thyroid Gland Carcinoma|Papillary Carcinoma Follicular Variant	A morphologic variant of papillary carcinoma of the thyroid gland characterized by the absence of papillary structures, and the presence of follicular structures.  The malignant follicular cells display the nuclear characteristics that characterize the papillary adenocarcinomas of the thyroid gland. (NCI05)
C7382	Testicular_Polyembryoma	Retired_Concepts	Testicular Mixed Germ Cell Tumor|Polyembryoma of Testis|Polyembryoma of the Testis|Testicular Polyembryoma
C7383	Papillary_Urothelial_Carcinoma	Bladder_Papillary_Urothelial_Neoplasm|Bladder_Urothelial_Carcinoma|Papillary_Transitional_Cell_Carcinoma	Bladder Papillary Urothelial Carcinoma|Urothelial Papillary Carcinoma of the Bladder	An invasive or non-invasive papillary transitional cell carcinoma of the urinary bladder.  It is classified as low - or high-grade. -- 2003
C7385	Trabecular_Follicular_Adenocarcinoma	Retired_Concepts	Thyroid Gland Trabecular Follicular Carcinoma|Trabecular Follicular Adenocarcinoma|Trabecular Follicular Carcinoma|Trabecular Follicular Thyroid Gland Carcinoma
C7386	Encapsulated_Thymoma	Thymoma	Encapsulated Thymoma	A thymoma that is confined within the capsule and may display benign or malignant morphologic characteristics. --2003
C7387	Blood_Vessel_Neoplasm	Vascular_Neoplasm	Blood Vessel Neoplasm|Blood Vessel Tumor
C7388	Vascular_Neoplasm	Cardiovascular_Neoplasm|Mesenchymal_Cell_Neoplasm|Vascular_Disorder	Vascular Neoplasm|Neoplasm of Vascular Tissue|Neoplasms, Vascular|Tumor of Vascular Tissue|Tumors, Vascular|Vascular Neoplasms|Vascular Tissue Neoplasm|Vascular Tissue Tumor|Vascular Tumor|Vascular Tumors	Benign and malignant neoplasms that arise from vascular tissue including arteries, veins, venous sinuses, arterioles and capillaries.  These lesions may occur in essentially any body location. (KEV 8-7-99)
C7389	Benign_Vascular_Neoplasm	Benign_Mesenchymal_Cell_Neoplasm|Vascular_Neoplasm	Benign Vascular Neoplasm|Benign Vascular Tumor|Vascular Neoplasms, Benign
C7390	Malignant_Vascular_Neoplasm	Vascular_Neoplasm	Malignant Vascular Neoplasm|Cancerous Tumor of Blood Vessel|Malignant Tumor of Blood Vessel|Malignant Vascular Tissue Neoplasm|Malignant Vascular Tissue Tumor|Malignant Vascular Tumor|Vascular Neoplasms, Malignant
C7391	Intermediate_Blood_Vessel_Neoplasm	Blood_Vessel_Neoplasm|Intermediate_Vascular_Neoplasm	Intermediate Blood Vessel Neoplasm|Intermediate Blood Vessel Tumor
C7392	Unresolved_Disease_NEC	Retired_Concepts	Unresolved Disease NEC
C7393	Skin_Epithelioid_Hemangioma	Epithelioid_Hemangioma|Hemangioma_of_the_Skin	Skin Epithelioid Hemangioma|Angiolymphoid Cutaneous Hyperplasia|Angiolymphoid Hyperplasia of Skin|Angiolymphoid Hyperplasia of the Skin|Epithelioid Hemangioma of Skin|Epithelioid Hemangioma of the Skin|Histiocytoid Hemangioma of Skin|Histiocytoid Hemangioma of the Skin
C7394	Cellular_Hemangioma_of_Infancy_Strawberry_Nevus	Retired_Concepts	Juvenile Capillary Hemangioma|Benign Hemangioendothelioma|Cellular Hemangioma of Infancy (Strawberry Nevus)|Infantile Hemangioma|Strawberry Angioma|Strawberry Birthmark|Strawberry Hemangioma|Strawberry Mark|Strawberry Nevus
C7395	Stage_I_Nasopharyngeal_Carcinoma	Nasopharyngeal_Carcinoma	Stage I Nasopharyngeal Carcinoma|Nasopharyngeal Cancer, Stage I|Stage I Carcinoma of Nasopharynx|Stage I Carcinoma of the Nasopharynx|Stage I Nasopharyngeal Cancer|Stage I Nasopharynx Carcinoma|stage I nasopharynx cancer	Cancer confined to the nasopharynx.
C7396	Stage_III_Nasopharyngeal_Carcinoma	Nasopharyngeal_Carcinoma	Stage III Nasopharyngeal Carcinoma|Nasopharyngeal Cancer, Stage III|Stage III Carcinoma of Nasopharynx|Stage III Carcinoma of the Nasopharynx|Stage III Nasopharyngeal Cancer|Stage III Nasopharynx Carcinoma|stage III nasopharynx cancer	Cancer that has spread to lymph nodes on both sides of the neck or has spread to nearby bones or sinuses.
C7397	Stage_IV_Nasopharyngeal_Carcinoma	Nasopharyngeal_Carcinoma	Stage IV Nasopharyngeal Carcinoma|Metastatic Carcinoma of Nasopharynx|Metastatic Carcinoma of the Nasopharynx|Metastatic Nasopharyngeal Cancer|Metastatic Nasopharyngeal Carcinoma|Metastatic Nasopharynx Carcinoma|Nasopharyngeal Cancer, Stage IV|Stage IV Carcinoma of Nasopharynx|Stage IV Carcinoma of the Nasopharynx|Stage IV Nasopharyngeal Cancer|Stage IV Nasopharynx Carcinoma|stage IV nasopharynx cancer	Stage IV includes: IVA: (T4, N0, M0); (T4, N1, M0); (T4, N2, M0); IVB (Any T, N3, M0); IVC (Any T, Any N, M1). T4: Tumor with intracranial extension and/or involvement of cranial nerves, infratemporal fossa, hypopharynx, orbit, or masticator space.  N3: Metastasis in a lymph node(s).  N3a: greater than 6 cm in dimension.  N3b: extension to the supraclavicular fossa.  M1: Distant metastasis. (AJCC 6th ed.) - 2003
C7398	Malignant_Oropharyngeal_Neoplasm	Malignant_Pharyngeal_Neoplasm|Oropharyngeal_Neoplasm	Malignant Oropharyngeal Neoplasm|Malignant Neoplasm of Oropharynx|Malignant Neoplasm of the Oropharynx|Malignant Oropharyngeal Tumor|Malignant Tumor of Oropharynx|Malignant Tumor of the Oropharynx	Malignant neoplasms of the oral cavity and pharynx
C7399	Villous_Adenoma	Adenomatous_Polyp	Villous Adenoma|villous adenoma	A type of polyp that grows in the colon and other places in the gastrointestinal tract and sometimes in other parts of the body. These adenomas may become malignant (cancerous).
C7400	Burkitt_s_Cell_Leukemia	Acute_Leukemia|Lymphoid_Leukemia	Burkitt's Leukemia|Burkitt's Cell Leukemia|Burkitt's leukemia|FAB L3|L3 Acute Lymphoblastic Leukemia|L3 Acute Lymphocytic Leukemia|L3 Acute Lymphogenous Leukemia|L3 Acute Lymphoid Leukemia	A rare, fast-growing cancer of the blood.  Also called B-cell acute lymphocytic leukemia or B-cell acute lymphoblastic leukemia.
C7401	Hairy_Cell_Leukemia_Variant	Hairy_Cell_Leukemia	Hairy Cell Leukemia Variant|HCL-V	A rare variant of Hairy Cell Leukemia in which the circulating lymphocytes have a round or oval nucleus and a prominent nucleolus.
C7402	Hairy_Cell_Leukemia	Chronic_Leukemia|Lymphoid_Leukemia|Mature_B-Cell_Lymphocytic_Neoplasm	Hairy Cell Leukemia|HCL|Leukemic Reticuloendotheliosis|hairy cell leukemia	A rare neoplasm of small B-lymphocytes with "hairy" projections in bone marrow, spleen and peripheral blood.  Most patients are middle-aged to elderly adults and present with splenomegaly and pancytopenia. (WHO, 2001) -- 2003
C7404	Malignant_Tonsillar_Neoplasm	Malignant_Oropharyngeal_Neoplasm|Tonsillar_Neoplasm	Malignant Tonsillar Neoplasm|Malignant Neoplasm of Tonsil|Malignant Neoplasm of the Tonsil|Malignant Tonsil Neoplasm|Malignant Tonsil Tumor|Malignant Tonsillar Tumor|Malignant Tumor of Tonsil|Malignant Tumor of the Tonsil	Malignant neoplasm of the tonsils
C7405	Chronic_Atrophic_Gastritis	Chronic_Gastritis|Gastric_Precancerous_Condition	Chronic Atrophic Gastritis|Gastric Atrophy|gastric atrophy	(GAS-trik AT-ro-fee) A condition in which the stomach muscles shrink and become weak. The digestive (peptic) glands may also shrink, resulting in a lack of digestive juices.
C7406	Oral_Lichen_Planus	Lichen_Planus	Oral Lichen Planus
C7407	Anal_Precancerous_Condition	Anal_Disorder|Gastrointestinal_Precancerous_Condition	Anal Precancerous Condition|Anal Premalignant Condition
C7408	Anal_Margin_Bowen_s_Disease	Anal_Margin_Intraepithelial_Neoplasia	Anal Margin Bowen's Disease|Anal Margin Squamous Dysplasia|Perianal Skin Bowen's Disease
C7409	Anal_Margin_Squamous_Dysplasia	Retired_Concepts	Anal Margin Squamous Dysplasia|Perianal Skin Bowen's Disease
C7410	Malignant_Vaginal_Neoplasm	Malignant_Female_Reproductive_System_Neoplasm|Vaginal_Neoplasm	Malignant Vaginal Neoplasm|Malignant Neoplasm of Vagina|Malignant Neoplasm of the Vagina|Malignant Tumor of Vagina|Malignant Tumor of the Vagina|Malignant Vagina Neoplasm|Malignant Vagina Tumor|Malignant Vaginal Tumor	A primary or metastatic malignant tumor involving the vagina.  Representative examples include carcinomas and sarcomas. -- 2003
C7411	Laryngeal_Precancerous_Condition	Head_and_Neck_Precancerous_Condition|Laryngeal_Disorder	Laryngeal Precancerous Condition|Laryngeal Premalignant Condition
C7412	Pancreatic_Precancerous_Condition	Exocrine_Pancreas_Neoplasm|Gastrointestinal_Precancerous_Condition	Pancreatic Precancerous Condition|Pancreatic Premalignant Condition
C7413	Nephrogenic_Adenoma	Non-Neoplastic_Urinary_Tract_Disorder	Nephrogenic Adenoma	So-called nephrogenic adenoma is a distinct metaplastic lesion of the urothelium characterized by aggregates of cuboidal or hobnail cells.  These cells line thin papillary fronds on the surface or form tubular structures within the lamina propria.
C7414	Urinary_Bladder_Villous_Adenoma	Bladder_Neoplasm	Bladder Villous Adenoma|Urinary Bladder Villous Adenoma|Villous Adenoma of Urinary Bladder|Villous Adenoma of the Urinary Bladder	An exophytic glandular neoplasm of the bladder, morphologically similar to its intestinal counterpart.  It often coexists with in situ or infiltrating bladder adenocarcinoma.
C7415	Urinary_Bladder_Nephrogenic_Adenoma	Nephrogenic_Adenoma|Non-Neoplastic_Bladder_Disorder	Urinary Bladder Nephrogenic Adenoma|Nephrogenic Adenoma of Urinary Bladder|Nephrogenic Adenoma of the Urinary Bladder
C7416	Urethral_Nephrogenic_Adenoma	Nephrogenic_Adenoma|Non-Neoplastic_Urethra_Disorder	Urethral Nephrogenic Adenoma|Nephrogenic Adenoma of Urethra|Nephrogenic Adenoma of the Urethra
C7417	Gallbladder_Hyperplastic_Polyp	Gallbladder_Polyp|Hyperplastic_Polyp	Gallbladder Hyperplastic Polyp|Hyperplastic Polyp of Gallbladder|Hyperplastic Polyp of the Gallbladder
C7418	Malignant_Rectal_Neoplasm	Malignant_Colorectal_Neoplasm|Rectal_Neoplasm	Malignant Rectal Neoplasm|Malignant Neoplasm of Rectum|Malignant Neoplasm of the Rectum|Malignant Rectal Tumor|Malignant Tumor of Rectum|Malignant Tumor of the Rectum	A primary or metastatic malignant neoplasm involving the rectum.
C7419	Acanthoma	Benign_Epithelial_Skin_Neoplasm	Acanthoma
C7420	Malignant_Rectosigmoid_Neoplasm	Malignant_Colorectal_Neoplasm|Rectosigmoid_Neoplasm	Malignant Rectosigmoid Neoplasm|Malignant Neoplasm of Rectosigmoid Junction|Malignant Neoplasm of the Rectosigmoid Junction|Malignant Rectosigmoid Tumor|Malignant Tumor of Rectosigmoid Junction|Malignant Tumor of the Rectosigmoid Junction	A malignant tumor involving the rectum and sigmoid colon.  The majority are carcinomas. -- 2003
C7421	Rectosigmoid_Carcinoma	Colorectal_Carcinoma|Malignant_Rectosigmoid_Neoplasm	Rectosigmoid Carcinoma|Rectosigmoid Cancer	A colorectal carcinoma involving the rectosigmoid area.  The majority are adenocarcinomas.  About 50% of colorectal carcinomas occur in the rectosigmoid area.  --2002
C7422	Precancerous_Condition_by_Site	Precancerous_Condition	Precancerous Condition by Site|Premalignant Condition by Site
C7423	Esophageal_Precancerous_Condition	Esophageal_Disorder|Gastrointestinal_Precancerous_Condition	Esophageal Precancerous Condition|Esophageal Premalignant Condition
C7424	Gastric_Precancerous_Condition	Gastrointestinal_Precancerous_Condition|Stomach_Disorder	Gastric Precancerous Condition|Gastric Premalignant Condition
C7425	Oral_Cavity_and_Lip_Precancerous_Condition	Head_and_Neck_Precancerous_Condition|Oral_Disorder	Oral Cavity and Lip Precancerous Condition|Oral Cavity and Lip Premalignant Condition
C7426	Metastatic_Neoplasm_to_the_Rectum	Malignant_Rectal_Neoplasm|Metastatic_Neoplasm_to_the_Large_Intestine	Metastatic Malignant Neoplasm to the Rectum|Metastasis to the Rectum|Metastatic Neoplasm to the Rectum|Metastatic Tumor to the Rectum
C7427	Nonencapsulated_Sclerosing_Carcinoma	Papillary_Thyroid_Carcinoma	Thyroid Gland Diffuse Sclerosing Papillary Carcinoma|Nonencapsulated Sclerosing Adenocarcinoma|Nonencapsulated Sclerosing Carcinoma|Nonencapsulated Sclerosing Neoplasm|Nonencapsulated Sclerosing Papillary Thyroid Carcinoma|Nonencapsulated Sclerosing Tumor	A morphologic variant of papillary carcinoma of the thyroid gland that more often affects young patients and commonly metastasizing to the lungs.  It is characterized by a diffuse infiltration of the thyroid gland by malignant follicular cells, squamous metaplasia, stromal fibrosis, and lymphocytic infiltration. (NCI05)
C7428	Nonencapsulated_Sclerosing_Neoplasm	Retired_Concepts	Nonencapsulated Sclerosing Neoplasm|Nonencapsulated Sclerosing Tumor
C7429	Nonencapsulated_Sclerosing_Adenocarcinoma	Retired_Concepts	Nonencapsulated Sclerosing Adenocarcinoma|Nonencapsulated Sclerosing Carcinoma|Nonencapsulated Sclerosing Neoplasm|Nonencapsulated Sclerosing Papillary Thyroid Carcinoma|Nonencapsulated Sclerosing Tumor
C7430	Malignant_Exocrine_Pancreas_Neoplasm	Exocrine_Pancreas_Neoplasm|Malignant_Pancreatic_Neoplasm	Malignant Exocrine Pancreas Neoplasm|Malignant Exocrine Pancreas Tumor|Malignant Neoplasm of Exocrine Pancreas|Malignant Neoplasm of the Exocrine Pancreas|Malignant Tumor of Exocrine Pancreas|Malignant Tumor of the Exocrine Pancreas
C7431	Malignant_Ovarian_Neoplasm	Malignant_Female_Reproductive_System_Neoplasm|Ovarian_Neoplasm	Malignant Ovarian Neoplasm|Cancer of Ovary|Cancer of the Ovary|Malignant Neoplasm of Ovary|Malignant Neoplasm of the Ovary|Malignant Ovarian Tumor|Malignant Tumor of Ovary|Malignant Tumor of the Ovary|Ovarian Cancer	A primary or metastatic malignant tumor involving the ovary.  Most primary malignant ovarian neoplasms are either carcinomas (serous, mucinous, or endometrioid adenocarcinomas) or malignant germ cell tumors.  Metastatic malignant neoplasms to the ovary include carcinomas, lymphomas, and melanomas. -- 2004
C7432	AIDS-Related_Cervical_Carcinoma	AIDS-Related_Carcinoma|AIDS-Related_Malignant_Cervical_Neoplasm|Cervical_Carcinoma	AIDS-Related Cervical Carcinoma|AIDS Related Carcinoma of Uterine Cervix|AIDS Related Carcinoma of the Uterine Cervix|AIDS Related Cervical Cancer|AIDS-Related Cancer of Uterine Cervix|AIDS-Related Cancer of the Uterine Cervix|AIDS-Related Cervical Cancer|AIDS-Related Cervix Carcinoma|AIDS-Related Uterine Cervix Cancer|AIDS-Related Uterine Cervix Carcinoma	Abnormal growth of the cells of the cervix with malignant characteristics. This concept specifically refers to this type of cancer in patients with acquired immunodeficiency syndrome.
C7433	V-Ras-Ha_Gene	AIDS-Related_Kaposi_s_Sarcoma|AIDS-Related_Malignant_Cervical_Neoplasm	AIDS-Related Cervical Kaposi's Sarcoma|AIDS-Related Kaposi's Sarcoma of Cervix|AIDS-Related Kaposi's Sarcoma of the Cervix
C7434	AIDS-Related_Non-Hodgkin_s_Lymphoma_of_the_Cervix	AIDS-Related_Malignant_Cervical_Neoplasm|AIDS-Related_Non-Hodgkin_s_Lymphoma	AIDS-Related Non-Hodgkin's Lymphoma of the Cervix|AIDS-Related Non-Hodgkin's Lymphoma of Cervix|AIDS-Related Uterine Cervical Non-Hodgkin's Lymphoma
C7435	Pulmonary_Precancerous_Condition	Lung_Disorder|Precancerous_Condition_by_Site	Pulmonary Precancerous Condition
C7436	Squamous_Lung_Dysplasia	Dysplasia	Squamous Lung Dysplasia
C7437	Diffuse_Idiopathic_Pulmonary_Neuroendocrine_Cell_Hyperplasia	Pulmonary_Precancerous_Condition	Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia|DIP-NECH|DIPNECH
C7438	Infiltrating_Papillary_Adenocarcinoma	Papillary_Adenocarcinoma	Infiltrating Papillary Adenocarcinoma
C7439	Intraductal_Papillary_Adenocarcinoma_with_Invasion	Papillary_Adenocarcinoma	Intraductal Papillary Adenocarcinoma with Invasion
C7440	Papilloma	Papillary_Epithelial_Neoplasm	Papilloma	A benign epithelial neoplasm that projects above the surrounding epithelial surface and consists of villous or arborescent outgrowths of fibrovascular stroma. --2004
C7441	Salivary_Gland_Myoepithelioma	Retired_Concepts	Salivary Gland Myoepithelioma|Myoepithelioma of Salivary Gland|Myoepithelioma of the Salivary Gland
C7442	Benign_Myoepithelioma	Myoepithelioma	Benign Myoepithelioma
C7443	Non-Infiltrating_Cystic_Hypersecretory_Duct_Breast_Carcinoma	Retired_Concepts	Non-Infiltrating Cystic Hypersecretory Duct Breast Carcinoma|Non-Infiltrating Cystic Hypersecretory Breast Carcinoma|Non-Infiltrating Cystic Hypersecretory Carcinoma of the Breast|Non-Infiltrating Cystic Hypersecretory Duct Carcinoma of the Breast|Non-Invasive Cystic Hypersecretory Breast Carcinoma|Non-Invasive Cystic Hypersecretory Carcinoma of the Breast|Non-Invasive Cystic Hypersecretory Duct Breast Carcinoma|Non-Invasive Cystic Hypersecretory Duct Carcinoma of the Breast
C7444	Infiltrating_Cystic_Hypersecretory_Duct_Breast_Carcinoma	Retired_Concepts	Infiltrating Cystic Hypersecretory Duct Breast Carcinoma|Invasive Cystic Hypersecretory Duct Breast Carcinoma
C7445	Brain_Stem_Astrocytoma	Astrocytic_Tumor|Brain_Stem_Glioma	Brain Stem Astrocytoma|Brain Stem Astrocytic Neoplasm|Brain Stem Astrocytic Tumor|Brainstem Astrocytic Tumor|Brainstem Astrocytoma	Abnormal growth of the glial cells that comprise the brainstem. This tumor is most easily detected on MRI. The form with the poorest prognosis (median survival of about 12 months) appears to be the diffusely infiltrative pontine lesion. However, it is important to note whether the patient has neurofibromatosis since the literature appears to show a more favorable prognosis for diffuse tumors in patients with neurofibromatosis type I.  The dorsally exophytic brainstem lesions has a slightly better expected survival. Brainstem glioma is most commonly found in children. There are preliminary findings in the literature that seem to indicate that adults with brainstem gliomas may have a better survival time. (Kaye AH, Laws ER Brain Tumors Churchill-Livingstone 1995)
C7446	Anaplastic_Brain_Stem_Glioma	Brain_Stem_Glioma|Malignant_Brain_Stem_Neoplasm	Anaplastic Brain Stem Glioma|Anaplastic Brainstem Glioma|Anaplastic Glioma of Brain Stem|Anaplastic Glioma of Brainstem|Anaplastic Glioma of the Brain Stem|Anaplastic Glioma of the Brainstem|Brain Stem Glioma, Grade III|Brainstem Glioma, Grade III|Grade III Brain Stem Glioma|Grade III Brainstem Glioma|Grade III Glioma of Brain Stem|Grade III Glioma of Brainstem|Grade III Glioma of the Brain Stem|Grade III Glioma of the Brainstem|Undifferentiated Brain Stem Glioma|Undifferentiated Brainstem Glioma|Undifferentiated Glioma of Brain Stem|Undifferentiated Glioma of Brainstem|Undifferentiated Glioma of the Brain Stem|Undifferentiated Glioma of the Brainstem
C7447	Granular_Cell_Odontogenic_Fibroma	Odontogenic_Fibroma	Granular Cell Odontogenic Fibroma
C7448	Hybrid_Odontogenic_Fibroma	Odontogenic_Fibroma	Hybrid Odontogenic Fibroma
C7449	Infiltrating_Angiolipoma	Angiolipoma	Infiltrating Angiolipoma
C7450	Intramuscular_Lipoma	Deep_Lipoma	Intramuscular Lipoma
C7451	Infiltrating_Lipoma	Deep_Lipoma	Infiltrating Lipoma
C7452	Odontogenic_Myxofibroma	Benign_Odontogenic_Neoplasm	Odontogenic Myxofibroma
C7453	Exocervical_Carcinoma	Cervical_Carcinoma|Malignant_Exocervical_Neoplasm	Exocervical Carcinoma|Carcinoma of Exocervix|Carcinoma of the Exocervix|Exocervix Carcinoma
C7454	Lung_Hilum_Carcinoma	Lung_Carcinoma|Malignant_Lung_Hilum_Neoplasm	Lung Hilum Carcinoma|Hilar Lung Carcinoma	A lung carcinoma arising from the hilum of the lung. (NCI05)
C7456	Metastatic_Malignant_Neoplasm_to_the_Ovary	Malignant_Ovarian_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Ovary|Metastases to Ovary|Metastasis to Ovary|Metastatic Malignant Tumor to the Ovary|Ovarian Metastasis	The spread of the cancer to the ovary.  This may be from a primary ovarian cancer involving the opposite ovary, or from a cancer at a distant site.
C7457	Capillary_Hemangioma	Hemangioma	Capillary Hemangioma|Capillary Angioma
C7458	Juvenile_Hemangioma	Retired_Concepts	Juvenile Capillary Hemangioma|Benign Hemangioendothelioma|Strawberry Nevus
C7459	Infantile_Hemangioma	Retired_Concepts	Infantile Hemangioma
C7460	Metastatic_Malignant_Neoplasm_to_the_Anus	Malignant_Anal_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Anus|Metastatic Malignant Tumor to the Anus
C7461	Growth_Hormone_Secreting_Pituitary_Adenoma	Growth_Hormone_Secreting_Pituitary_Neoplasm|Pituitary_Gland_Adenoma	Growth Hormone Producing Pituitary Gland Adenoma|GH Cell Adenoma|Growth Hormone Producing Adenoma of Pituitary|Growth Hormone Producing Adenoma of Pituitary Gland|Growth Hormone Producing Adenoma of the Pituitary|Growth Hormone Producing Adenoma of the Pituitary Gland|Growth Hormone Producing Pituitary Adenoma|Growth Hormone Secreting Adenoma of Pituitary|Growth Hormone Secreting Adenoma of Pituitary Gland|Growth Hormone Secreting Adenoma of the Pituitary|Growth Hormone Secreting Adenoma of the Pituitary Gland|Growth Hormone Secreting Pituitary Adenoma|Growth Hormone Secreting Pituitary Gland Adenoma|Somatotroph Adenoma	An adenoma of the anterior lobe of the pituitary gland that produces growth hormone.  The vast majority of cases are hormonally functioning and are associated with either gigantism or acromegaly. (NCI05)
C7462	Pituitary_Corticotropin_Secreting_Adenoma	Pituitary_Corticotropin_Secreting_Tumor|Pituitary_Gland_Adenoma	ACTH Producing Pituitary Gland Adenoma|ACTH Secreting Adenoma of Pituitary|ACTH Secreting Adenoma of the Pituitary|ACTH-Secreting Adenoma of Pituitary|ACTH-Secreting Adenoma of Pituitary Gland|ACTH-Secreting Adenoma of the Pituitary|ACTH-Secreting Adenoma of the Pituitary Gland|ACTHoma|Adrenocorticotropin Producing Adenoma of Pituitary|Adrenocorticotropin Producing Adenoma of Pituitary Gland|Adrenocorticotropin Producing Adenoma of the Pituitary|Adrenocorticotropin Producing Adenoma of the Pituitary Gland|Adrenocorticotropin Producing Pituitary Adenoma|Adrenocorticotropin Producing Pituitary Gland Adenoma|Adrenocorticotropin Secreting Adenoma of Pituitary|Adrenocorticotropin Secreting Adenoma of Pituitary Gland|Adrenocorticotropin Secreting Adenoma of the Pituitary|Adrenocorticotropin Secreting Adenoma of the Pituitary Gland|Adrenocorticotropin Secreting Pituitary Adenoma|Adrenocorticotropin Secreting Pituitary Gland Adenoma|Corticotroph Adenoma|Corticotropin Secreting Adenoma of the Pituitary|Corticotropin Secreting Pituitary Gland Adenoma|Corticotropinoma|Pituitary ACTH Secreting Adenoma|Pituitary ACTH-Secreting Adenoma|Pituitary Corticotropin Secreting Adenoma|Pituitary Gland ACTH-Secreting Adenoma	An adenoma of the pituitary gland that produces corticotropin.  The vast majority of cases are associated with Cushing disease.  Clinical manifestations include truncal obesity with thin extremities, thinning of the skin, osteoporosis, and a tendency to bruise easily.  Silent or hormonally non-functioning ACTH producing adenomas have also been described.  They produce symptoms of a mass-related lesion. (NCI05)
C7463	Acute_Myelomonocytic_Leukemia	Acute_Myeloid_Leukemia_not_Otherwise_Categorized	Acute Myelomonocytic Leukemia|AMML|Acute M4 Myeloid Leukemia|Acute Myelomonocytic Leukemia (FAB Type M4)	An acute leukemia characterized by the proliferation of both neutrophil and monocyte precursors.  Patients typically present with anemia, thrombocytopenia, fever and fatigue.  This type of leukemia frequently responds to aggressive therapy.  (WHO, 2001) -- 2003
C7464	Acute_Leukemia_of_Ambiguous_Lineage	Acute_Leukemia	Acute Leukemia of Ambiguous Lineage|Acute Leukemia of Indeterminate Lineage|Mixed-Cell Leukemia	An acute leukemia in which the blasts lack sufficient evidence to classify as myeloid or lymphoid or they have morphologic and/or immunophenotypic characteristics of both myeloid and lymphoid cells.  The prognosis is usually unfavorable.  (WHO, 2001) -- 2003
C7465	AIDS-Related_Anal_Non-Hodgkins_Lymphoma	AIDS-Related_Malignant_Anal_Neoplasm|AIDS-Related_Non-Hodgkin_s_Lymphoma|Anal_Lymphoma|Gastrointestinal_Non-Hodgkin_s_Lymphoma	AIDS-Related Anal Non-Hodgkin's Lymphoma|AIDS-Related Primary Anal Non-Hodgkin's Lymphoma
C7466	Acute_Erythroid_Leukemia_in_Remission	Acute_Myeloid_Leukemia_in_Remission	Acute Erythroid Leukemia in Remission	Acute erythroid leukemia that is responding to therapy, i.e. It is not progressing and possibly regressing
C7467	Pure_Erythroid_Leukemia	Acute_Erythroid_Leukemia	Pure Erythroid Leukemia|Acute Myeloid Leukemia M6b|Erythremic Myelosis|M6b	Acute erythroid leukemia characterised by the presence of immature erythroid cells in the bone marrow (at least 80% of the cellular component), without evidence of a significant myeloblastic cell population present. -- 2003
C7468	Struma_Ovarii	Ovarian_Monodermal_and_Highly_Specialized_Teratoma	Struma Ovarii
C7469	Anal_Canal_Squamous_Cell_Carcinoma	Anal_Canal_Carcinoma|Anal_Squamous_Cell_Carcinoma	Anal Canal Squamous Cell Carcinoma
C7470	Anal_Verrucous_Carcinoma	Anal_Squamous_Cell_Carcinoma	Anal Verrucous Carcinoma|Anal Buschke-Lowenstein Tumor|Anal Giant (Malignant) Condyloma
C7471	Anal_Canal_Adenocarcinoma	Anal_Adenocarcinoma|Anal_Canal_Carcinoma	Anal Canal Adenocarcinoma|Adenocarcinoma of Anal Canal|Adenocarcinoma of the Anal Canal
C7472	Anal_Margin_Carcinoma	Anal_Carcinoma|Skin_Carcinoma	Anal Margin Carcinoma|Carcinoma of Anal Margin|Carcinoma of the Anal Margin|Perianal Skin Carcinoma	A carcinoma arising in the anal margin or perianal skin (below the anal verge and involving the perianal hair-bearing skin).  It includes basal cell and squamous cell carcinoma.  Anal margin carcinoma is staged as a skin carcinoma, separately from anal canal carcinoma.  -- 2003
C7473	Anal_Margin_Basal_Cell_Carcinoma	Anal_Margin_Carcinoma|Basal_Cell_Carcinoma	Anal Margin Basal Cell Carcinoma|Basal Cell Carcinoma of Anal Margin|Basal Cell Carcinoma of Perianal Skin|Basal Cell Carcinoma of the Anal Margin|Basal Cell Carcinoma of the Perianal Skin|Perianal Skin Basal Cell Carcinoma
C7474	Anal_Extramucosal_Perianal_Adenocarcinoma	Anal_Adenocarcinoma	Anal Extramucosal (Perianal) Adenocarcinoma|Extramucosal (Perianal) Adenocarcinoma of Anus|Extramucosal (Perianal) Adenocarcinoma of the Anus
C7475	Anal_Adenocarcinoma_within_Anorectal_Fistula	Anal_Extramucosal_Perianal_Adenocarcinoma	Anal Adenocarcinoma within Anorectal Fistula|Adenocarcinoma of Anus within Anorectal Fistula|Adenocarcinoma of the Anus within Anorectal Fistula
C7476	Anal_Margin_Paget_s_Disease	Anal_Margin_Carcinoma|Anal_Margin_Intraepithelial_Neoplasia|Anal_Paget_s_Disease	Paget's Disease of the Anal Margin|Anal Margin Paget's Disease|Perianal Skin Paget's Disease
C7477	Anal_Canal_Paget_s_Disease	Anal_Canal_Adenocarcinoma|Anal_Canal_Intraepithelial_Neoplasia|Anal_Paget_s_Disease	Paget's Disease of the Anal Canal|Anal Canal Paget's Disease|Paget's Disease of Anal Canal
C7478	Malignant_Esophageal_Neoplasm	Esophageal_Neoplasm|Malignant_Gastrointestinal_Neoplasm	Malignant Esophageal Neoplasm|Malignant Esophageal Tumor|Malignant Esophagus Tumor|Malignant Neoplasm of Esophagus|Malignant Neoplasm of the Esophagus|Malignant Tumor of Esophagus|Malignant Tumor of the Esophagus	A primary or metastatic malignant neoplasm involving the esophagus
C7479	Metastatic_Neoplasm_to_the_Esophagus	Malignant_Esophageal_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Esophagus|Esophageal Metastasis|Metastases to Esophagus|Metastases to the Esophagus|Metastasis to Esophagus|Metastasis to the Esophagus|Metastatic Neoplasm to the Esophagus|Metastatic Tumor to the Esophagus
C7480	Malignant_Fallopian_Tube_Neoplasm	Fallopian_Tube_Neoplasm|Malignant_Female_Reproductive_System_Neoplasm	Malignant Fallopian Tube Neoplasm|Fallopian Tube Malignant Neoplasm|Fallopian Tube Malignant Tumor|Malignant Fallopian Tube Tumor|Malignant Neoplasm of Fallopian Tube|Malignant Neoplasm of the Fallopian Tube|Malignant Tumor of Fallopian Tube|Malignant Tumor of the Fallopian Tube|Neoplasm, Fallopian Tube, Malignant|Tumor, Fallopian Tube, Malignant
C7481	Malignant_Gallbladder_Neoplasm	Gallbladder_Neoplasm|Malignant_Hepato-Biliary_Neoplasm	Malignant Gallbladder Neoplasm|Malignant Gallbladder Tumor|Malignant Neoplasm of Gallbladder|Malignant Neoplasm of the Gallbladder|Malignant Tumor of Gallbladder|Malignant Tumor of the Gallbladder	Primary or metastatic malignant neoplasm of the gallbladder.
C7482	Metastatic_Neoplasm_to_the_Gallbladder	Malignant_Gallbladder_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Gallbladder|Metastatic Neoplasm to the Gallbladder|Metastatic Tumor to the Gallbladder|Secondary Malignant Neoplasm to the Gallbladder|Secondary Malignant Tumor to the Gallbladder
C7483	Malignant_Extrahepatic_Bile_Duct_Neoplasm	Extrahepatic_Bile_Duct_Neoplasm|Malignant_Hepato-Biliary_Neoplasm	Malignant Extrahepatic Bile Duct Neoplasm|Malignant Extrahepatic Bile Duct Tumor|Malignant Neoplasm of Extrahepatic Bile Duct|Malignant Neoplasm of the Extrahepatic Bile Duct|Malignant Tumor of Extrahepatic Bile Duct|Malignant Tumor of the Extrahepatic Bile Duct	A malignant tumor involving the extrahepatic bile duct. -- 2003
C7484	Malignant_Laryngeal_Neoplasm	Laryngeal_Neoplasm|Malignant_Neck_Neoplasm	Malignant Laryngeal Neoplasm|Malignant Laryngeal Tumor|Malignant Larynx Neoplasm|Malignant Larynx Tumor|Malignant Neoplasm of Larynx|Malignant Neoplasm of the Larynx|Malignant Tumor of Larynx|Malignant Tumor of the Larynx	A primary or metastatic malignant tumor involving the larynx.  The majority are carcinomas. -- 2003
C7485	Malignant_Lip_Neoplasm	Lip_Neoplasm|Malignant_Oral_Neoplasm	Malignant Lip Neoplasm|Malignant Lip Tumor|Malignant Neoplasm of Lip|Malignant Neoplasm of the Lip|Malignant Tumor of Lip|Malignant Tumor of the Lip	Abnormal growth, with malignant characteristics, of the cells that comprise the lips of the mouth.
C7486	Paranasal_Sinus_Polyp	Benign_Paranasal_Sinus_Neoplasm|Polyp	Paranasal Sinus Polyp|Accessory Sinus Polyp|Polyp of Accessory Sinus|Polyp of Paranasal Sinus|Polyp of the Accessory Sinus|Polyp of the Paranasal Sinus
C7487	Malignant_Paranasal_Sinus_Neoplasm	Paranasal_Sinus_Neoplasm	Malignant Paranasal Sinus Neoplasm|Malignant Accessory Sinus Neoplasm|Malignant Accessory Sinus Tumor|Malignant Neoplasm of Accessory Sinus|Malignant Neoplasm of Paranasal Sinus|Malignant Neoplasm of the Accessory Sinus|Malignant Neoplasm of the Paranasal Sinus|Malignant Paranasal Sinus Tumor|Malignant Tumor of Accessory Sinus|Malignant Tumor of Paranasal Sinus|Malignant Tumor of the Accessory Sinus|Malignant Tumor of the Paranasal Sinus	A primary or metastatic malignant neoplasm involving the paranasal sinuses.
C7488	Paranasal_Sinus_Neoplasm	Nasal_Cavity_and_Paranasal_Sinus_Neoplasm|Paranasal_Sinus_Disorder	Paranasal Sinus Neoplasm|Accessory Sinus Neoplasm|Accessory Sinus Tumor|Neoplasm of Accessory Sinus|Neoplasm of Paranasal Sinus|Neoplasm of the Accessory Sinus|Neoplasm of the Paranasal Sinus|Paranasal Sinus Neoplasms|Paranasal Sinus Tumor|Tumor of Accessory Sinus|Tumor of Paranasal Sinus|Tumor of the Accessory Sinus|Tumor of the Paranasal Sinus
C7489	Anal_Canal_Carcinoma	Anal_Carcinoma	Anal Canal Carcinoma|Anal Canal Cancer|Anal Canal and Perianal Gland Cancer|Anal Canal and Perianal Gland Carcinoma	A squamous cell carcinoma or less frequently an adenocarcinoma, often associated with human papilloma virus (HPV) infection.  Homosexual men are at particular risk.  The most important prognostic factors are tumor stage and nodal status.  -- 2003
C7490	Anal_Canal_Intraepithelial_Neoplasia	Anal_Intraepithelial_Neoplasia	Anal Canal Intraepithelial Neoplasia|Anal Canal Squamous Dysplasia|Squamous Dysplasia in the Anal Canal
C7491	Primary_Intraosseous_Carcinoma_Arising_de_novo	Carcinoma|Malignant_Odontogenic_Neoplasm	Primary Intraosseous Carcinoma Arising de novo
C7492	Ameloblastic_Carcinoma	Ameloblastoma|Carcinoma|Malignant_Odontogenic_Neoplasm	Ameloblastic Carcinoma	A rare, cytologically malignant ameloblastoma that may metastasize. -- 2004
C7493	De_novo_Ameloblastic_Carcinoma	Ameloblastic_Carcinoma	De novo Ameloblastic Carcinoma
C7494	Central_Ameloblastic_Carcinoma	Ameloblastic_Carcinoma	Central Ameloblastic Carcinoma
C7495	Peripheral_Ameloblastic_Carcinoma	Ameloblastic_Carcinoma	Peripheral Ameloblastic Carcinoma
C7496	Ameloblastic_Carcinoma_ex_Ameloblastoma	Ameloblastic_Carcinoma	Ameloblastic Carcinoma Ex Ameloblastoma
C7497	Ameloblastic_Carcinoma_ex_Odontogenic_Cyst	Ameloblastic_Carcinoma	Ameloblastic Carcinoma Ex Odontogenic Cyst
C7498	Keratinizing_Primary_Intraosseous_Carcinoma_Arising_de_novo	Primary_Intraosseous_Carcinoma_Arising_de_novo	Keratinizing Primary Intraosseous Carcinoma Arising de novo
C7499	Non-Keratinizing_Primary_Intraosseous_Carcinoma_Arising_de_novo	Primary_Intraosseous_Carcinoma_Arising_de_novo	Non-Keratinizing Primary Intraosseous Carcinoma Arising de novo
C7500	Primary_Intraosseous_Carcinoma_ex_Odontogenic_Cyst	Carcinoma|Malignant_Odontogenic_Neoplasm	Primary Intraosseous Carcinoma Ex Odontogenic Cyst
C7501	Odontogenic_Myxoma	Benign_Odontogenic_Neoplasm|Myxoma	Odontogenic Myxoma
C7502	Malignant_Vulvar_Neoplasm	Malignant_Female_Reproductive_System_Neoplasm|Vulvar_Neoplasm	Malignant Vulvar Neoplasm|Malignant Neoplasm of Vulva|Malignant Neoplasm of the Vulva|Malignant Tumor of Vulva|Malignant Tumor of the Vulva|Malignant Vulva Neoplasm|Malignant Vulva Tumor|Malignant Vulvar Tumor	Primary or metastatic malignant neoplasm involving the vulva. --2003
C7503	Borderline_Phyllodes_Tumor	Neoplasm_of_Uncertain_Malignant_Potential|Phyllodes_Tumor	Borderline Phyllodes Tumor|Borderline Phyllodes Neoplasm
C7504	Cystic_Nephroma	Renal_Neoplasm	Cystic Nephroma
C7505	Malignant_Cystic_Nephroma	Cystic_Nephroma|Malignant_Renal_Neoplasm	Malignant Cystic Nephroma
C7506	Refractory_Anemia_with_Excess_Blasts	Myelodysplastic_Syndrome	Refractory Anemia with Excess Blasts|RAEB-MT|Refractory Anemia with an Excess of Blasts	A myelodysplastic syndrome with 5-19% myeloblasts in the bone marrow.  It includes two categories: RAEB-1, and RAEB-2.  (WHO, 2001) -- 2003
C7507	Malignant_Urethral_Neoplasm	Malignant_Urinary_Tract_Neoplasm|Urethra_Neoplasm	Malignant Urethral Neoplasm|Malignant Neoplasm of Urethra|Malignant Neoplasm of the Urethra|Malignant Tumor of Urethra|Malignant Tumor of the Urethra|Malignant Urethra Neoplasm|Malignant Urethra Tumor|Malignant Urethral Tumor	Abnormal malignant growth of cells in the urethra (lower urinary tract).
C7508	Recurrent_Urethral_Cancer	Recurrent_Urinary_Tract_Cancer|Urethral_Carcinoma	Recurrent Urethral Cancer|Recurrent Cancer of Urethra|Recurrent Cancer of the Urethra|Recurrent Urethra Cancer|Recurrent Urethra Carcinoma|Relapsed Cancer of Urethra|Relapsed Cancer of the Urethra|Relapsed Urethra Cancer|Relapsed Urethra Carcinoma|Relapsed Urethral Cancer|Urethral Cancer, Recurrent	The reemergence of urethral cancer after a period of remission
C7509	Metastatic_Neoplasm_to_the_Thyroid_Gland	Malignant_Thyroid_Neoplasm|Metastatic_Neoplasm_to_the_Neck	Metastatic Malignant Neoplasm to the Thyroid Gland|Metastasis to the Thyroid|Metastasis to the Thyroid Gland|Metastatic Malignant Neoplasm to the Thyroid|Metastatic Malignant Tumor to the Thyroid|Metastatic Malignant Tumor to the Thyroid Gland|Metastatic Neoplasm to the Thyroid|Metastatic Neoplasm to the Thyroid Gland|Metastatic Tumor to the Thyroid|Metastatic Tumor to the Thyroid Gland|Secondary Malignant Neoplasm to the Thyroid|Secondary Malignant Neoplasm to the Thyroid Gland|Secondary Malignant Tumor to the Thyroid|Secondary Malignant Tumor to the Thyroid Gland	A malignant neoplasm either directly extending to the thyroid gland from adjacent structures (e.g. pharynx, larynx, esophagus, cervical lymph nodes), or spreading to the thyroid gland from distant anatomic sites, most frequently kidney, lung, uterus, breast, and skin.  The majority of cases are carcinomas, lymphomas, and melanomas.(NCI05)
C7510	Malignant_Thyroid_Neoplasm	Malignant_Neck_Neoplasm|Thyroid_Neoplasm	Malignant Thyroid Gland Neoplasm|Malignant Neoplasm of Thyroid|Malignant Neoplasm of Thyroid Gland|Malignant Neoplasm of the Thyroid|Malignant Neoplasm of the Thyroid Gland|Malignant Thyroid Gland Tumor|Malignant Thyroid Neoplasm|Malignant Thyroid Tumor|Malignant Tumor of Thyroid|Malignant Tumor of Thyroid Gland|Malignant Tumor of the Thyroid|Malignant Tumor of the Thyroid Gland	A primary or metastatic malignant neoplasm affecting the thyroid gland. --2005
C7511	Metastatic_Neoplasm_to_the_Breast	Malignant_Breast_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Breast|Breast Metastases|Breast Metastasis|Metastatic Cancer to the Breast|Metastatic Neoplasm to the Breast|Metastatic Tumor to the Breast	The spread of cancer to the breast. This may be from a primary breast cancer on the opposite side, or from a cancer at a distant site.
C7512	Malignant_Esophageal_Neoplasm_by_Anatomic_Region	Malignant_Esophageal_Neoplasm	Malignant Esophageal Neoplasm by Anatomic Region	Esophageal segments used primarily for clinical purposes, and distinct from the topographic segments used in pathology.
C7513	Malignant_Esophageal_Neoplasm_by_Topographic_Region	Malignant_Esophageal_Neoplasm	Malignant Esophageal Neoplasm by Topographic Region	Esophageal segments used primarily in pathology, and distinct from the anatomic segments used for clinical purposes.
C7514	Kidney_and_Ureter_Neoplasm	Urinary_Tract_Neoplasm	Kidney and Ureter Neoplasm|Kidney and Ureter Tumor|Renal and Ureteral Neoplasm|Renal and Ureteral Tumor
C7515	Renal_Pelvis_and_Ureter_Carcinoma	Kidney_and_Ureter_Neoplasm|Malignant_Urinary_Tract_Neoplasm	Renal Pelvis and Ureter Carcinoma|Renal Pelvis and Ureter Cancer
C7517	Stage_0a_Renal_Pelvis_and_Ureter_Carcinoma	Intraurothelial_Neoplasia|Papillary_Urothelial_Neoplasm|Stage_0_Renal_Pelvis_and_Ureter_Carcinoma|Stage_0_Transitional_Cell_Carcinoma|Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter	Stage 0a Renal Pelvis and Ureter Carcinoma|Stage 0a Renal Pelvis and Ureter Cancer
C7518	Stage_0is_Renal_Pelvis_and_Ureter_Carcinoma	Intraurothelial_Neoplasia|Stage_0_Renal_Pelvis_and_Ureter_Carcinoma|Stage_0_Transitional_Cell_Carcinoma|Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter	Stage 0is Renal Pelvis and Ureter Carcinoma|Stage 0is Renal Pelvis and Ureter Cancer
C7519	Stage_I_Renal_Pelvis_and_Ureter_Carcinoma	Renal_Pelvis_and_Ureter_Carcinoma	Stage I Renal Pelvis and Ureter Carcinoma|Stage I Renal Pelvis and Ureter Cancer
C7520	Stage_II_Renal_Pelvis_and_Ureter_Carcinoma	Renal_Pelvis_and_Ureter_Carcinoma	Stage II Renal Pelvis and Ureter Carcinoma|Stage II Renal Pelvis and Ureter Cancer
C7521	Stage_III_Renal_Pelvis_and_Ureter_Carcinoma	Renal_Pelvis_and_Ureter_Carcinoma	Stage III Renal Pelvis and Ureter Carcinoma|Stage III Renal Pelvis and Ureter Cancer
C7522	Stage_IV_Renal_Pelvis_and_Ureter_Carcinoma	Renal_Pelvis_and_Ureter_Carcinoma	Stage IV Renal Pelvis and Ureter Carcinoma|Stage IV Renal Pelvis and Ureter Cancer
C7523	Malignant_Small_Intestinal_Neoplasm	Malignant_Intestinal_Neoplasm|Small_Intestinal_Neoplasm	Malignant Small Intestinal Neoplasm|Malignant Neoplasm of Small Bowel|Malignant Neoplasm of Small Intestine|Malignant Neoplasm of the Small Bowel|Malignant Neoplasm of the Small Intestine|Malignant Small Bowel Neoplasm|Malignant Small Bowel Tumor|Malignant Small Intestine Neoplasm|Malignant Small Intestine Tumor|Malignant Tumor of Small Bowel|Malignant Tumor of Small Intestine|Malignant Tumor of the Small Bowel|Malignant Tumor of the Small Intestine	A primary or metastatic malignant neoplasm involving the small intestine
C7524	Metastasis_to_the_Small_Intestine	Malignant_Small_Intestinal_Neoplasm	Metastastatic Neoplasm to the Small Intestine|Metastases to Small Intestine|Metastasis to the Small Bowel|Metastasis to the Small Intestine|Secondary Malignant Neoplasm to the Small Bowel|Secondary Malignant Neoplasm to the Small Intestine|Secondary Malignant Tumor to the Small Bowel|Secondary Malignant Tumor to the Small Intestine	The spread of the cancer to the small intestine.  This may be from a primary intestinal cancer, or from a cancer at a distant site.
C7525	Malignant_Renal_Pelvis_Neoplasm	Malignant_Renal_Neoplasm|Renal_Pelvis_Neoplasm	Malignant Renal Pelvis Neoplasm|Malignant Neoplasm of Renal Pelvis|Malignant Neoplasm of the Renal Pelvis|Malignant Renal Pelvis Tumor|Malignant Tumor of Renal Pelvis|Malignant Tumor of the Renal Pelvis	Abnormal malignant growth of the cells within the renal pelvis.
C7526	Endovascular_Papillary_Angioendothelioma	Hemangioendothelioma|Intermediate_Rarely_Metastasizing_Blood_Vessel_Neoplasm	Papillary Intralymphatic Angioendothelioma|Dabska Tumor|Papillary Endovascular Angioendothelioma
C7527	Malignant_Superior_Sulcus_Neoplasm	Malignant_Lung_Neoplasm|Pulmonary_Sulcus_Neoplasm	Malignant Superior Sulcus Neoplasm|Malignant Superior Sulcus Lung Neoplasm|Malignant Superior Sulcus Lung Tumor|Malignant Superior Sulcus Neoplasm of Lung|Malignant Superior Sulcus Neoplasm of the Lung|Malignant Superior Sulcus Tumor|Malignant Superior Sulcus Tumor of Lung|Malignant Superior Sulcus Tumor of the Lung|Pancoast Tumor|Pancoast Tumour|Pancoast tumor|Pancoast's Tumor	A malignant neoplasm originating from the apical lung. Most malignant superior sulcus neoplasms are bronchogenic carcinomas. This tumor may be associated with Pancoast syndrome. Also known as Pancoast tumor. --2004
C7528	Angioimmunoblastic_T-Cell_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Angioimmunoblastic T-Cell Lymphoma|AILT|Angioimmunoblastic Lymphadenopathy Type T-Cell Lymphoma	A mature T-cell non-Hodgkin's lymphoma, characterized by systemic disease and a polymorphous infiltrate involving lymph nodes.  It occurs in the middle aged and elderly, with an equal incidence in males and females.  The clinical course is typically aggressive.  (WHO, 2001) -- 2003
C7529	Recurrent_Childhood_Visual_Pathway_Glioma	Childhood_Visual_Pathway_Glioma|Recurrent_Childhood_Brain_Neoplasm	Recurrent Childhood Visual Pathway Glioma|Recurrent Childhood Optic Tract Glioma|Recurrent Glioma of Childhood Visual Pathway|Recurrent Glioma of Pediatric Visual Pathway|Recurrent Glioma of the Childhood Visual Pathway|Recurrent Glioma of the Pediatric Visual Pathway|Recurrent Pediatric Optic Tract Glioma|Recurrent Pediatric Visual Pathway Glioma|Relapsed Childhood Visual Pathway Glioma|Relapsed Glioma of Childhood Visual Pathway|Relapsed Glioma of Pediatric Visual Pathway|Relapsed Glioma of the Childhood Visual Pathway|Relapsed Glioma of the Pediatric Visual Pathway|Relapsed Pediatric Visual Pathway Glioma
C7530	Recurrent_Childhood_Visual_Pathway_Astrocytoma	Childhood_Visual_Pathway_Astrocytoma|Recurrent_Childhood_Visual_Pathway_Glioma	Recurrent Childhood Visual Pathway Astrocytoma|Recurrent Childhood Optic Tract Astrocytoma|Recurrent Pediatric Optic Tract Astrocytoma|Recurrent Pediatric Visual Pathway Astrocytoma
C7531	Recurrent_Childhood_Optic_Nerve_Glioma	Recurrent_Childhood_Visual_Pathway_Glioma	Recurrent Childhood Optic Nerve Glioma|Recurrent Pediatric Optic Nerve Glioma
C7532	Recurrent_Childhood_Optic_Nerve_Astrocytoma	Recurrent_Childhood_Optic_Nerve_Glioma|Recurrent_Childhood_Visual_Pathway_Astrocytoma	Recurrent Childhood Optic Nerve Astrocytoma|Recurrent Pediatric Optic Nerve Astrocytoma
C7533	Visual_Pathway_Astrocytoma	Astrocytic_Tumor|Visual_Pathway_Glioma	Visual Pathway Astrocytoma|Optic Tract Astrocytoma	Abnormal growth of cells that comprise the optic tract. This condition can be seen in association with Neurofibromatosis 1. It is most commonly seen in the pediatric age group.
C7534	Childhood_Visual_Pathway_Astrocytoma	Childhood_Visual_Pathway_Glioma|Visual_Pathway_Astrocytoma	Childhood Visual Pathway Astrocytoma|Childhood Optic Tract Astrocytoma|Pediatric Optic Tract Astrocytoma|Pediatric Visual Pathway Astrocytoma
C7535	Childhood_Visual_Pathway_Glioma	Childhood_Brain_Neoplasm|Visual_Pathway_Glioma	Childhood Visual Pathway Glioma|Childhood Optic Tract Glioma|Glioma of Childhood Visual Pathway|Glioma of Pediatric Visual Pathway|Glioma of the Childhood Visual Pathway|Glioma of the Pediatric Visual Pathway|Pediatric Optic Tract Glioma|Pediatric Visual Pathway Glioma	An abnormal growth of the cells that comprise the optic tract.  It presents most commonly in the first two decades of life. It is associated with Neurofibromatosis 1 (NF1.)
C7536	Desmoplastic_Nodular_Medulloblastoma	Desmoplastic_Medulloblastoma	Desmoplastic Nodular Medulloblastoma	Desmoplastic Medulloblastoma is a variant of Medulloblastoma. Some histologic features of this lesion include nodular, reticulin-free zones ('pale islands') surrounded by densely packed, highly proliferative cells that produce a dense intercellular reticulin fiber network. (Adapted from WHO.)
C7538	Anterior_Visual_Pathway_Meningioma	Visual_Pathway_Meningioma	Anterior Visual Pathway Meningioma|Anterior Optic Tract Meningioma
C7539	Lymphoid_Leukemia	Leukemia|Lymphocytic_Neoplasm	Lymphoid Leukemia|Lymphocytic Leukemia|Lymphogenous Leukemia	A malignant lymphocytic neoplasm of B-cell or T-cell lineage involving primarily the bone marrow and the peripheral blood.  This category includes precursor or acute lymphoblastic leukemias and chronic leukemias. --2003
C7540	Small_Lymphocytic_Lymphoma	Chronic_Lymphocytic_Leukemia_Small_Lymphocytic_Lymphoma|Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Small Lymphocytic Lymphoma|B-Cell Small Lymphocytic Lymphoma|Diffuse Well Differentiated Lymphocytic Lymphoma|SLL|Small B-Cell Lymphocytic Lymphoma	A non-Hodgkin's lymphoma composed of monomorphic small, round B-lymphocytes in the lymph nodes.  When the lymphoid process involves predominantly the bone marrow and the peripheral blood it is called chronic lymphocytic leukemia. (WHO, 2001) -- 2003
C7541	Retinoblastoma	Malignant_Retinal_Neoplasm|Retinal_Cell_Neoplasm	Retinoblastoma|RB|retinoblastoma	A malignant tumor that originates in the nuclear layer of the retina. As the most common primary tumor of the eye in children, retinoblastoma is still relatively uncommon, accounting for only 1% of all malignant tumors in pediatric patients. These tumors may be multifocal, bilateral, congenital, inherited, or acquired. Seventy-five percent of retinoblastomas are unilateral; 60% occur sporadically. A predisposition to retinoblastoma has been associated with 13q14 cytogenetic abnormalities. Patients with the inherited form also appear to be at increased risk for secondary nonocular malignancies such as osteosarcoma, malignant fibrous histiocytoma, and fibrosarcoma. --2004
C7542	Askin_s_Tumor	Peripheral_Primitive_Neuroectodermal_Tumor	Askin's Tumor|PNET of Thoracopulmonary Region|Peripheral Neuroectodermal Tumor of Thoracopulmonary Region|Small Cell Tumor of Thoracopulmonary Region	A primitive neuroectodermal tumor (small round blue cell tumor) of the thorax which can involve the periosteum, thoracic wall and/or pleura though it spares the lung parenchyma.
C7543	Malignant_Ureter_Neoplasm	Malignant_Urinary_Tract_Neoplasm|Ureter_Neoplasm	Malignant Ureter Neoplasm|Malignant Neoplasm of Ureter|Malignant Neoplasm of the Ureter|Malignant Tumor of Ureter|Malignant Tumor of the Ureter|Malignant Ureter Tumor|Malignant Ureteral Neoplasm|Malignant Ureteral Tumor	A primary or metastatic malignant tumor involving the ureter.  The majority are carcinomas. -- 2003
C7544	Metastatic_Neoplasm_to_the_Ureter	Malignant_Ureter_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Ureter|Metastasis to the Ureter|Metastatic Neoplasm to the Ureter|Metastatic Tumor to the Ureter	A malignant tumor that has spread to the ureter from another anatomic site. --2003
C7545	Malignant_Pharyngeal_Neoplasm	Malignant_Neck_Neoplasm|Pharyngeal_Neoplasm	Malignant Pharyngeal Neoplasm|Malignant Pharyngeal Tumor|Malignant Pharynx Neoplasm|Malignant Pharynx Tumor|Malignant Tumor of Pharynx|Malignant Tumor of the Pharynx	Malignant neoplasm of the pharynx.
C7546	Metastatic_Neoplasm_to_the_Pharynx	Malignant_Pharyngeal_Neoplasm|Metastatic_Neoplasm_to_the_Neck	Metastatic Malignant Neoplasm to the Pharynx|Metastasis to the Pharynx|Metastatic Neoplasm to the Pharynx|Metastatic Tumor to the Pharynx
C7547	Malignant_Penile_Neoplasm	Malignant_Male_Reproductive_System_Neoplasm|Penile_Neoplasm	Malignant Penile Neoplasm|Malignant Neoplasm of Penis|Malignant Neoplasm of the Penis|Malignant Penile Tumor|Malignant Tumor of Penis|Malignant Tumor of the Penis	Primary or metastatic malignant neoplasm involving the penis. --2003
C7548	Malignant_Renal_Neoplasm	Malignant_Urinary_Tract_Neoplasm|Renal_Neoplasm	Malignant Renal Neoplasm|Malignant Kidney Neoplasm|Malignant Kidney Tumor|Malignant Neoplasm of Kidney|Malignant Neoplasm of the Kidney|Malignant Renal Tumor|Malignant Tumor of Kidney|Malignant Tumor of the Kidney	Primary or metastatic malignant neoplasm involving the kidney. --2003
C7549	Metastatic_Neoplasm_to_the_Kidney	Malignant_Renal_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Kidney|Metastases to Kidney|Metastases to the Kidney|Metastasis to Kidney|Metastasis to the Kidney|Metastatic Neoplasm to the Kidney|Metastatic Tumor to the Kidney|Renal Metastases|Renal Metastasis	The spread of the cancer to the kidney.  This may be from a primary kidney cancer involving the opposite kidney, or from a cancer at a distant site.
C7550	Ovarian_Serous_Adenocarcinoma	Malignant_Ovarian_Serous_Tumor|Ovarian_Adenocarcinoma|Serous_Adenocarcinoma	Ovarian Serous Adenocarcinoma|Ovarian Serous Carcinoma|Serous Adenocarcinoma of Ovary|Serous Adenocarcinoma of the Ovary|Serous Carcinoma of Ovary|Serous Carcinoma of the Ovary	Ovarian serous adenocarcinoma is a serous neoplasm characterized by nuclear atypia, high mitotic activity, stratification, glandular complexity, branching papillary fronds and stromal invasion. --2002
C7551	Stage_III_Prostate_Cancer	Prostate_Carcinoma	Stage III Prostate Cancer|Cancer of Prostate Stage III|Cancer of the Prostate Stage III|Prostate Cancer Stage III|Prostate Carcinoma Stage III|Stage III Cancer of Prostate|Stage III Cancer of the Prostate|Stage III Prostate Carcinoma|Stage III Prostatic Cancer|Stage III Prostatic Carcinoma|stage III prostate cancer	Cancer cells have spread outside the covering (capsule) of the prostate to tissues around the prostate but not to the lymph nodes. The glands that produce semen (the seminal vesicles) may have cancer cells in them. Similar to stage C in the Whitmore-Jewett staging system.
C7552	Stage_C_Prostate_Cancer	Prostate_Cancer_by_Whitmore-Jewett_Stage|Stage_III_Prostate_Cancer	Stage C Prostate Cancer|Stage C Prostate Carcinoma	Tumor is clinically localized to the periprostatic area, but extends through the prostatic capsule; the seminal vesicles may be involved. -- 2004
C7553	Stage_II_Prostate_Cancer	Prostate_Carcinoma	Stage II Prostate Cancer|Cancer of Prostate Stage II|Cancer of the Prostate Stage II|Prostate Cancer Stage II|Prostate Carcinoma Stage II|Stage II Cancer of Prostate|Stage II Cancer of the Prostate|Stage II Prostate Carcinoma|Stage II Prostatic Cancer|Stage II Prostatic Carcinoma|stage II prostate cancer	Cancer that may be found by a needle biopsy performed because a blood test showed elevated prostate-specific antigen (PSA); or cancer that may be felt in the prostate during a rectal examination, even though the cancer cells are found only in the prostate gland. Similar to stage B in the Whitmore-Jewett staging system.
C7554	Stage_B_Prostate_Cancer	Prostate_Cancer_by_Whitmore-Jewett_Stage|Stage_II_Prostate_Cancer	Stage B Prostate Cancer|Stage B Prostate Carcinoma|Stage B Prostatic Cancer|Stage B Prostatic Carcinoma	Tumor is clinically palpable but confined to the prostate. -- 2004
C7555	Stage_I_Prostate_Cancer	Prostate_Carcinoma	Stage I Prostate Cancer|Cancer of Prostate Stage I|Cancer of the Prostate Stage I|Prostate Cancer Stage I|Prostate Carcinoma Stage I|Stage I Cancer of Prostate|Stage I Cancer of the Prostate|Stage I Prostate Carcinoma|Stage I Prostatic Cancer|Stage I Prostatic Carcinoma|stage I prostate cancer	Cancer that is only in the prostate gland, cannot be felt during a digital rectal examination, is not visible by imaging, and causes no symptoms.  It is usually found accidentally or because a blood test showed an elevated prostate-specific antigen (PSA) level.  Cancer cells may be found in only one area of the prostate, or they may be found in many areas of the prostate.  Similar to stage A in the Whitmore-Jewett staging system.
C7556	Stage_A_Prostate_Cancer	Prostate_Cancer_by_Whitmore-Jewett_Stage	Stage A Prostate Cancer|Stage A Prostate Carcinoma	A clinically undetectable tumor confined to the prostate gland, normally an incidental finding during surgery. -- 2004
C7558	Endometrial_Carcinoma	Carcinoma|Common_Carcinoma|Malignant_Endometrial_Neoplasm	Endometrial Carcinoma|Cancer of Endometrium|Cancer of the Endometrium|Carcinoma of Endometrium|Carcinoma of the Endometrium|Endometrial Cancer|Endometrium Cancer	A malignant tumor arising from the epithelium that lines the cavity of the uterine body.  The vast majority of endometrial carcinomas are adenocarcinomas; squamous cell and adenosquamous carcinomas represent a minority of the cases.  Endometrioid adenocarcinoma is the most frequently seen variant of endometrial adenocarcinoma.  Uterine bleeding is an initial clinical sign.  The prognosis depends on the stage of the tumor, the depth of myometrial wall invasion, and the degree of differentiation. -- 2004
C7559	Atypical_Adenoma	Adenoma	Atypical Adenoma
C7560	Sweat_Gland_Adenoma	Benign_Sweat_Gland_Neoplasm|Skin_Appendage_Adenoma	Sweat Gland Adenoma|Adenoma of Sweat Gland|Adenoma of the Sweat Gland
C7561	Syringadenoma	Apocrine_Adenoma	Syringadenoma
C7563	Hidradenoma	Apocrine_Adenoma	Hidradenoma
C7565	Eccrine_Cystadenoma	Benign_Eccrine_Neoplasm|Hidrocystoma	Eccrine Hidrocystoma|Eccrine Cystadenoma
C7566	Sporadic_Breast_Carcinoma	Breast_Carcinoma	Sporadic Breast Carcinoma|Sporadic Breast Cancer
C7567	Clear_Cell_Hidradenoma	Hidradenoma	Clear Cell Hidradenoma	An uncommon benign neoplasm of the sweat glands characterized by the presence of clear cells.
C7568	Nodular_Hidradenoma	Hidradenoma	Nodular Hidradenoma
C7569	Thymoma_Type_C	Malignant_Thymus_Neoplasm|Thymus_Epithelial_Neoplasm	Thymic Carcinoma|Thymic Carcinoma (Excluding Well Differentiated Thymic Carcinoma)|Thymic Carcinoma Excluding Well Differentiated Thymic Carcinoma|Thymoma Type C	A diverse group of carcinomas of the thymus gland, previously known as thymoma type C (WHO-1999).  It includes morphologic variants derived from purely epithelial cells, as well as from cells with neuroendocrine differentiation.  -- 2005
C7570	Melanocytic_Nevus	Common_Neoplasm|Melanocytic_Skin_Neoplasm	Melanocytic Nevus|Melanotic Nevus|Mole|Mole of Skin|Nevus|mole|nevus	(NEE-vus) A benign growth on the skin, such as a mole. A mole is a cluster of melanocytes and surrounding supportive tissue that usually appears as a tan, brown, or flesh-colored spot on the skin. The plural of nevus is nevi (NEE-vye).
C7571	Benign_Melanocytic_Nevus	Melanocytic_Nevus	Benign Melanocytic Nevus|Benign Melanocytic Nevus of Skin|Benign Melanocytic Nevus of the Skin|Benign Melanocytic Skin Nevus|Benign Mole|Benign Nevus of Skin|Benign Nevus of the Skin|Benign Skin Nevus	This is a skin neoplasm composed of clusters of benign nevus cells.
C7572	Renal_Medullary_Carcinoma	Renal_Cell_Carcinoma	Renal Medullary Carcinoma|Bellini Duct Carcinoma|Bellini duct carcinoma	A recently described type of renal cell carcinoma, affecting mostly young African-Americans.  It is located in the medulla of the kidney, and follows an aggressive clinical course.  Most reported cases have shown metastatic disease at the time of diagnosis. -- 2003
C7573	Metastatic_Neoplasm_to_the_Urethra	Malignant_Urethral_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Urethra|Metastasis to the Urethra|Metastatic Neoplasm to the Urethra
C7574	Phyllodes_Tumor_of_the_Prostate	Phyllodes_Tumor|Prostate_Neoplasm	Prostate Phyllodes Tumor|Cystosarcoma Phyllodes of Prostate|Cystosarcoma Phyllodes of the Prostate|Phyllodes Neoplasm of Prostate|Phyllodes Neoplasm of the Prostate|Phyllodes Tumor of Prostate|Phyllodes Tumor of the Prostate|Prostate Cystosarcoma Phyllodes|Prostate Phyllodes Neoplasm
C7575	Phyllodes_Tumor_of_the_Breast	Breast_Fibroepithelial_Neoplasm|Phyllodes_Tumor	Breast Phyllodes Tumor|Breast Cystosarcoma Phyllodes|Breast Phyllodes Neoplasm|Cystosarcoma Phyllodes of Breast|Cystosarcoma Phyllodes of the Breast|Phyllodes Breast Neoplasm|Phyllodes Breast Tumor|Phyllodes Neoplasm of Breast|Phyllodes Neoplasm of the Breast|Phyllodes Tumor of Breast|Phyllodes Tumor of the Breast
C7576	Deep_Penetrating_Nevus	Benign_Melanocytic_Nevus	Deep Penetrating Nevus
C7577	Recurrent_Nevus	Benign_Melanocytic_Nevus	Recurrent Nevus
C7578	Nevus_of_External_Female_Genitalia	Melanocytic_Nevus	Nevus of Female Genitalia
C7580	Skin_Appendage_Adenoma	Adenoma|Benign_Skin_Appendage_Neoplasm	Skin Appendage Adenoma|Adenoma of Adnexa|Adenoma of Skin Appendage|Adnexal Adenoma
C7581	Microcystic_Adnexal_Carcinoma	Eccrine_Adenocarcinoma	Microcystic Adnexal Carcinoma
C7582	Nevus_of_Ito	Congenital_Melanocytic_Skin_Nevus	Nevus of Ito|Hypomelanosis of Ito|Ito's Nevus
C7583	Nevus_of_Ota	Congenital_Melanocytic_Skin_Nevus	Nevus of Ota|Oculocutaneous Melanocytic Nevus|Oculodermal Melanocytosis|Ota's Nevus
C7584	Dysplastic_Nevus_Syndrome	Hereditary_Neoplastic_Syndrome	Dysplastic Nevus Syndrome|Atypical Mole Syndrome|B-K Mole Syndrome|Familial Dysplastic Nevi|Schimmelpeming Feurstein Mims Syndrome|familial dysplastic nevi	(fa-MI-lee-yul dis-PLAS-tik NEE-vye) A condition that runs in certain families in which at least two members have dysplastic nevi (atypical moles) and have a tendency to develop melanoma.
C7585	Adamantinoid_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma	Skin Adamantinoid Basal Cell Carcinoma|Skin Adamantinoid Basal Cell Epithelioma
C7586	Malignant_Basal_Cell_Neoplasm	Basal_Cell_Neoplasm	Malignant Basal Cell Neoplasm
C7587	Adult_Lymphoma	Lymphoma	Adult Lymphoma
C7588	Common_Hematopoietic_Neoplasm	Common_Neoplasm	Common Hematopoietic Neoplasm|Common Hematopoietic Tumor
C7589	Common_Epithelial_Neoplasm	Retired_Concepts	Common Epithelial Neoplasm|Common Epithelial Tumor
C7590	Common_Neuroendocrine_Neoplasm	Retired_Concepts	Common Neuroendocrine Neoplasm|Common Neuroendocrine Tumor
C7591	Combined_Lung_Carcinoma	Complex_Epithelial_Neoplasm|High_Grade_Lung_Neuroendocrine_Neoplasm|Lung_Carcinoma|Neuroendocrine_Carcinoma	Combined Lung Carcinoma|Combined Carcinoma of Lung|Combined Carcinoma of the Lung	A lung carcinoma characterized by the presence of large or small neuroendocrine carcinoma cells in combination with malignant glandular or squamous epithelial cells. (NCI05)
C7592	Common_Nervous_System_Neoplasm	Retired_Concepts	Common Nervous System Neoplasm|Common Nervous System Tumor
C7593	Common_Germ_Cell_Neoplasm	Common_Neoplasm	Common Germ Cell Tumor|Common Germ Cell Neoplasm
C7594	Common_Connective_and_Soft_Tissue_Neoplasm	Common_Neoplasm	Common Connective and Soft Tissue Neoplasm|Common Connective and Soft Tissue Tumor
C7595	Common_Melanocytic_Neoplasm	Retired_Concepts	Common Melanocytic Neoplasm
C7596	Myoepithelial_Carcinoma	Carcinoma|Infrequent_Neoplasm|Myoepithelioma	Malignant Myoepithelioma|Myoepithelial Carcinoma
C7597	Stage_IV_Vaginal_Cancer	Vaginal_Carcinoma	Stage IV Vaginal Cancer|Stage IV Vaginal Carcinoma	Stage IV includes: IVA: (T4, Any N, M0) and IVB: (Any T, Any N, M1).  T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify tumor as T4.) M1: Distant metastasis.  (AJCC 6th ed.) - 2003
C7598	Bone_Liposarcoma	Bone_Sarcoma|Liposarcoma	Bone Liposarcoma|Liposarcoma of Bone|Liposarcoma of the Bone
C7600	Acute_Myeloid_Leukemia_with_Multilineage_Dysplasia	Acute_Myeloid_Leukemia	Acute Myeloid Leukemia with Multilineage Dysplasia	An acute myeloid leukemia (AML) with at least 20% blasts in the marrow or blood, and dysplasia in 2 or more myeloid cell lines.  Dysplasia must be present in at least 50% of the cells of at least 2 cell lines.  Patients with this type of AML often present with severe cytopenia.  The presence of multilineage dysplasia has an adverse effect on the probability of achieving complete remission.  (WHO, 2001) -- 2003
C7601	Thyroid_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue|Thyroid_Non-Hodgkin_s_Lymphoma	Thyroid Gland Mucosa-Associated Lymphoid Tissue Lymphoma|Thyroid MALT Lymphoma|Thyroid Mucosa-Associated Lymphoid Tissue Lymphoma	An extranodal marginal zone B-cell lymphoma arising from mucosa-associated lymphoid tissue in the thyroid gland.  The vast majority of cases are associated with chronic lymphocytic thyroiditis. (NCI05)
C7602	Halo_Nevus	Benign_Melanocytic_Nevus|Melanocytic_Skin_Neoplasm	Halo Nevus|HN	A benign melanocytic nevus with a halo appearance. --2003
C7603	Regressing_Nevus	Benign_Melanocytic_Nevus	Regressing Nevus
C7604	Nasal_Cavity_Olfactory_Neuroblastoma	Malignant_Nasal_Cavity_Neoplasm|Olfactory_Neuroblastoma	Nasal Cavity Olfactory Neuroblastoma|Olfactory Neuroblastoma of Nasal Cavity|Olfactory Neuroblastoma of the Nasal Cavity
C7605	Oral_Cavity_Benign_Granular_Cell_Tumor	Benign_Granular_Cell_Tumor|Benign_Oral_Cavity_Neoplasm|Oral_Cavity_Granular_Cell_Tumor	Oral Cavity Benign Granular Cell Tumor|Oral Cavity Benign Granular Cell Neoplasm
C7606	Oral_Cavity_Neoplasm	Oral_Cavity_Disorder|Oral_Neoplasm	Oral Cavity Neoplasm|Mouth Neoplasm|Mouth Tumor|Oral Cavity Tumor	A benign or malignant tumor involving the oral cavity and/or the lips. -- 2003
C7607	Benign_Oral_Cavity_Neoplasm	Benign_Oral_Neoplasm|Oral_Cavity_Neoplasm	Benign Oral Cavity Neoplasm|Benign Mouth Neoplasm|Benign Mouth Tumor|Benign Neoplasm of Mouth|Benign Neoplasm of Oral Cavity|Benign Neoplasm of the Mouth|Benign Neoplasm of the Oral Cavity|Benign Oral Cavity Tumor|Benign Tumor of Mouth|Benign Tumor of Oral Cavity|Benign Tumor of the Mouth|Benign Tumor of the Oral Cavity
C7608	Benign_Oral_Neoplasm	Oral_Neoplasm	Benign Oral Neoplasm|Benign Oral Tumor|Oral Neoplasm, Benign
C7609	Cerebral_Non-Hodgkin_s_Lymphoma	Cerebral_Lymphoma|Non-Hodgkin_s_Lymphoma	Cerebral Non-Hodgkin's Lymphoma|Cerebral Non-Hodgkin Lymphoma|Primary Cerebral Non-Hodgkin Lymphoma|Primary Cerebral Non-Hodgkin's Lymphoma
C7610	Primary_Cerebral_Non-Hodgkin_s_Lymphoma	Retired_Concepts	Primary Cerebral Non-Hodgkin's Lymphoma|Primary Cerebral Non-Hodgkin Lymphoma
C7611	Cerebral_Lymphoma	Central_Nervous_System_Lymphoma|Malignant_Cerebral_Neoplasm	Cerebral Lymphoma|Primary Cerebral Lymphoma|Primary Lymphoma of Cerebrum|Primary Lymphoma of the Cerebrum|Primary Lymphoma, Brain
C7612	Malignant_Thymoma	Malignant_Thymus_Neoplasm|Thymoma	Malignant Thymoma	A thymoma that has an aggressive clinical course (capsular invasion, infiltration of the surrounding tissues) and can metastasize.  Although any morphologic subtype of thymoma may eventually have a malignant clinical course, this term is most often associated with thymoma types B3 and C.  --2003
C7613	Primary_Cutaneous_Hodgkin_s_Lymphoma	Retired_Concepts	Primary Cutaneous Hodgkin's Lymphoma|Primary Cutaneous Hodgkin Disease|Primary Cutaneous Hodgkin Lymphoma|Primary Cutaneous Hodgkin's Disease	Primary cutaneous Hodgkin's lymphoma is rare.  This diagnosis can only be made when there is no evidence of Hodgkin's lymphoma in the lymph nodes or other anatomic sites.  Patients usually present with papules or nodular lesions.  Morphologically, primary cutaneous Hodgkin's lymphoma may resemble lymphomatoid papulosis or anaplastic large cell lymphoma.  Immunohistochemical tissue evaluation is essential in establishing the diagnosis. --2003
C7614	Cutaneous_Lymphoproliferative_Disorder	Lymphoproliferative_Disorder|Skin_Disorder	Cutaneous Lymphoproliferative Disorder|Lymphoproliferative Disorder of Skin|Lymphoproliferative Disorder of the Skin
C7615	Adult_Diffuse_Large_B-Cell_Lymphoma	Adult_Non-Hodgkin_s_Lymphoma|Diffuse_Large_B-Cell_Lymphoma	Adult Diffuse Large B-Cell Lymphoma
C7616	Childhood_Diffuse_Large_B_Cell_Lymphoma	Childhood_Non-Hodgkin_s_Lymphoma|Diffuse_Large_B-Cell_Lymphoma	Childhood Diffuse Large B -Cell Lymphoma|Pediatric Diffuse Large B Cell Lymphoma
C7617	Benign_Reproductive_System_Neoplasm	Reproductive_System_Neoplasm	Benign Reproductive System Neoplasm
C7618	Benign_Mesenchymal_Cell_Neoplasm	Mesenchymal_Cell_Neoplasm	Benign Mesenchymal Cell Neoplasm
C7619	Recurrent_Carcinoma	Carcinoma	Recurrent Carcinoma|Recurrent Cancer|Relapsed Cancer|Relapsed Carcinoma
C7620	Recurrent_Female_Reproductive_System_Cancer	Recurrent_Carcinoma	Recurrent Female Reproductive System Cancer|Recurrent Female Reproductive System Carcinoma
C7621	Recurrent_Male_Reproductive_System_Cancer	Recurrent_Carcinoma	Recurrent Male Reproductive System Cancer|Recurrent Male Reproductive System Carcinoma
C7622	Recurrent_Gastrointestinal_System_Cancer	Recurrent_Carcinoma	Recurrent Gastrointestinal System Cancer|Recurrent Gastrointestinal System Carcinoma
C7623	Recurrent_Urinary_Tract_Cancer	Recurrent_Carcinoma	Recurrent Urinary Tract Cancer|Recurrent Urinary Tract Carcinoma
C7624	Recurrent_Head_and_Neck_Cancer	Recurrent_Carcinoma	Recurrent Head and Neck Cancer|Recurrent Head and Neck Carcinoma
C7625	Localized_Carcinoma	Carcinoma	Localized Carcinoma|Localized Cancer
C7626	Recurrent_Pancreatic_Cancer	Pancreatic_Carcinoma|Recurrent_Gastrointestinal_System_Cancer	Recurrent Pancreatic Cancer|Pancreatic Carcinoma, Recurrent|Recurrent Cancer of Pancreas|Recurrent Cancer of the Pancreas|Recurrent Carcinoma of Pancreas|Recurrent Carcinoma of the Pancreas|Recurrent Pancreatic Carcinoma|Relapsed Cancer of Pancreas|Relapsed Cancer of the Pancreas|Relapsed Carcinoma of Pancreas|Relapsed Carcinoma of the Pancreas|Relapsed Pancreatic Cancer|Relapsed Pancreatic Carcinoma	The reemergence of pancreatic carcinoma after a period of remission.
C7627	Bilateral_Malignant_Neoplasm	Malignant_Neoplasm	Bilateral Malignant Neoplasm|Bilateral Cancer|Bilateral Malignant Tumor
C7628	Refractory_Neoplasm	Neoplasm_by_Special_Category	Refractory Neoplasm|Refractory Tumor
C7629	Common_Carcinoma	Common_Neoplasm	Common Carcinoma
C7630	Intermediate_Lipomatous_Neoplasm	Intermediate_Soft_Tissue_Neoplasm|Lipomatous_Neoplasm	Intermediate Lipomatous Neoplasm	A lipomatous neoplasm characterized by a high risk of local recurrence and no risk of metastasis. -- 2003
C7631	Malignant_Pericardial_Mesothelioma	Malignant_Mesothelioma|Malignant_Pericardial_Neoplasm|Pericardial_Mesothelioma	Pericardial Malignant Mesothelioma|Malignant Mesothelioma of Pericardium|Malignant Mesothelioma of the Pericardium	This is a rare tumor.  Approximately 100 to 150 cases have been reported in the literature.  In most cases the diagnosis is made at autopsy or postoperatively.  Clinical signs and symptoms include: pericardial effusion, congestive heart failure, a mass or tamponade.  The prognosis for pericardial mesothelioma is extremely poor due to its late presentation and difficulty in completely removing it surgically.  Surgical resection remains the treatment of choice.  Addition of chemotherapy or radiation have been disappointing. - 2002
C7632	Pericardial_Mesothelioma	Mesothelioma	Pericardial Mesothelioma
C7633	Peritoneal_Mesothelioma	Mesothelioma|Peritoneal_Neoplasm	Peritoneal Mesothelioma|Mesothelioma of Peritoneum|Mesothelioma of the Peritoneum
C7634	Solitary_Fibrous_Tumor	Benign_Fibrous_Soft_Tissue_Neoplasm	Solitary Fibrous Tumor|Localized Fibrous Mesothelioma|Localized Fibrous Tumor|SFT|Submesothelial Fibroma	A localized benign neoplasm of probable fibroblastic derivation.
C7635	Well-Differentiated_Papillary_Mesothelioma	Mesothelioma	Well Differentiated Papillary Mesothelioma|Benign/Intermediate Mesothelioma|Well-Differentiated Mesothelial Papillary Neoplasm|Well-Differentiated Mesothelial Papillary Tumor|Well-Differentiated Papillary Neoplasm of Mesothelium|Well-Differentiated Papillary Neoplasm of the Mesothelium|Well-Differentiated Papillary Tumor of Mesothelium|Well-Differentiated Papillary Tumor of the Mesothelium
C7636	Progressive_Myoclonus_Epilepsy	Epilepsy	Progressive Myoclonus Epilepsy
C7637	Malignant_Labia_Minora_Neoplasm	Malignant_Vulvar_Neoplasm	Malignant Labia Minora Neoplasm|Malignant Labia Minora Tumor|Malignant Neoplasm of Labia Minora|Malignant Neoplasm of the Labia Minora|Malignant Tumor of Labia Minora|Malignant Tumor of the Labia Minora
C7638	Malignant_Labia_Majora_Neoplasm	Malignant_Vulvar_Neoplasm	Malignant Labia Majora Neoplasm|Malignant Labia Majora Tumor|Malignant Neoplasm of Labia Majora|Malignant Neoplasm of the Labia Majora|Malignant Tumor of Labia Majora|Malignant Tumor of the Labia Majora
C7639	Regional_Malignant_Urethral_Neoplasm	Malignant_Urethral_Neoplasm	Regional Malignant Urethral Neoplasm|Local Malignant Neoplasm of Urethra|Local Malignant Neoplasm of the Urethra|Local Malignant Tumor of Urethra|Local Malignant Tumor of the Urethra|Local Malignant Urethra Neoplasm|Local Malignant Urethra Tumor|Local Malignant Urethral Neoplasm|Local Malignant Urethral Tumor|Regional Malignant Neoplasm of Urethra|Regional Malignant Neoplasm of the Urethra|Regional Malignant Tumor of Urethra|Regional Malignant Tumor of the Urethra|Regional Malignant Urethra Neoplasm|Regional Malignant Urethra Tumor|Regional Malignant Urethral Tumor	Abnormal malignant growth of cells in the urethra without spread to any other region.
C7640	Posterior_Urethral_Malignant_Neoplasm	Female_Urethral_Malignant_Neoplasm	Posterior Urethral Malignant Neoplasm|Malignant Neoplasm of Posterior Urethra|Malignant Neoplasm of the Posterior Urethra|Malignant Tumor of Posterior Urethra|Malignant Tumor of the Posterior Urethra|Posterior Urethra Malignant Neoplasm|Posterior Urethra Malignant Tumor|Posterior Urethral Malignant Tumor
C7641	Anterior_Urethral_Malignant_Neoplasm	Female_Urethral_Malignant_Neoplasm	Anterior Urethral Malignant Neoplasm|Anterior Urethra Malignant Neoplasm|Anterior Urethra Malignant Tumor|Anterior Urethral Malignant Tumor|Malignant Neoplasm of Anterior Urethra|Malignant Neoplasm of the Anterior Urethra|Malignant Tumor of Anterior Urethra|Malignant Tumor of the Anterior Urethra
C7642	Epipodophyllotoxin-Related_Myelodysplastic_Syndrome	Therapy-Related_Myelodysplastic_Syndrome	Epipodophyllotoxin-Related Myelodysplastic Syndrome|Epipodophyllotoxin Related Myelodysplastic Syndrome
C7643	Alkylating_Agent-Related_Myelodysplastic_Syndrome	Alkylating_Agent-Related_Acute_Myeloid_Leukemia_and_Myelodysplastic_Syndrome|Therapy-Related_Myelodysplastic_Syndrome	Alkylating Agent-Related Myelodysplastic Syndrome|Alkylating Agent Related Myelodysplastic Syndrome
C7644	Adamantinoma	Malignant_Bone_Neoplasm|Neoplasm_of_Uncertain_Histogenesis	Adamantinoma
C7645	Intracystic_Papillary_Carcinoma	Ductal_Carcinoma_in_situ_of_the_Breast|Intraductal_Papillary_Breast_Carcinoma	Intracystic Papillary Breast Carcinoma|Intracystic Breast Carcinoma|Intracystic Papillary Adenocarcinoma|Noninfiltrating Intracystic Breast Carcinoma	A carcinoma entirely confined to the ducts.  While intraductal (or DCIS) carcinomas can arise at other sites, these terms are universally used to refer to carcinomas of the breast.
C7646	Adrenal_Ganglioneuroblastoma	Malignant_Adrenal_Medulla_Neoplasm|Peripheral_Ganglioneuroblastoma	Adrenal Gland Ganglioneuroblastoma|Adrenal Ganglioneuroblastoma
C7648	Adult_Mesoblastic_Nephroma	Retired_Concepts	Adult Mesoblastic Nephroma
C7649	Localized_Gallbladder_Carcinoma	Gallbladder_Carcinoma|Localized_Carcinoma	Localized Gallbladder Carcinoma|Gallbladder Cancer, Localized|Localized Cancer of Gallbladder|Localized Cancer of the Gallbladder|Localized Gallbladder Cancer|localized gallbladder cancer	Cancer found only in the tissues that make up the wall of the gallbladder. Localized gallbladder cancer can be removed completely in an operation.
C7650	Metastatic_Neoplasm_to_the_Bladder	Malignant_Bladder_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Bladder|Metastases to Bladder|Metastasis to Bladder|Metastatic Neoplasm to the Bladder|Metastatic Neoplasm to the Urinary Bladder|Metastatic Tumor to the Bladder|Metastatic Tumor to the Urinary Bladder	The spread of cancer to the urinary bladder wall from an adjacent or distant anatomic site.
C7651	Metastatic_Neoplasm_to_Major_Site	Retired_Concepts	Metastatic Neoplasm to Major Site
C7653	Intermediate_Soft_Tissue_Neoplasm	Mesenchymal_Cell_Neoplasm|Neoplasm_of_Uncertain_Malignant_Potential	Intermediate Soft Tissue Neoplasm
C7654	Cellular_Precursor_of_Cancer	Precancerous_Condition	Cellular Precursor of Cancer|Precancerous Cellular Change
C7655	Hepato-Biliary_Precancerous_Condition	Gastrointestinal_Precancerous_Condition|Liver_and_Biliary_Tract_Disorder	Hepato-Biliary Precancerous Condition|Hepato-Biliary Premalignant Condition
C7656	Hepatic_Dysplastic_Nodule	Hepatic_Disorder|Hepato-Biliary_Precancerous_Condition	Hepatic Dysplastic Nodule|Dysplastic Nodule of Liver|Dysplastic Nodule of the Liver
C7657	Intestinal_Precancerous_Condition	Gastrointestinal_Precancerous_Condition|Intestinal_Disorder	Intestinal Precancerous Condition|Intestinal Premalignant Condition
C7658	Intestinal_Intraepithelial_Neoplasia	Gastrointestinal_Intraepithelial_Neoplasia|Glandular_Cell_Intraepithelial_Neoplasia|Intestinal_Neoplasm|Intestinal_Precancerous_Condition	Intestinal Intraepithelial Neoplasia|Bowel Dysplasia|Intestinal Dysplasia
C7659	Gastrointestinal_Precancerous_Condition	Gastrointestinal_Disorder|Precancerous_Condition_by_Site	Gastrointestinal Precancerous Condition|Gastrointestinal Premalignant Condition
C7660	Grade_II_Glandular_Intraepithelial_Neoplasia	Grade_II_Intraepithelial_Neoplasia|High_Grade_Glandular_Intraepithelial_Neoplasia	Grade II Glandular Intraepithelial Neoplasia|Grade 2 Glandular Intraepithelial Neoplasia|Moderate Glandular Dysplasia
C7661	Low_Grade_Glandular_Intraepithelial_Neoplasia	Glandular_Cell_Intraepithelial_Neoplasia|Low_Grade_Intraepithelial_Neoplasia	Low Grade Glandular Intraepithelial Neoplasia|Grade 1 Glandular Intraepithelial Neoplasia|Grade I Glandular Intraepithelial Neoplasia
C7662	High_Grade_Glandular_Intraepithelial_Neoplasia	Glandular_Cell_Intraepithelial_Neoplasia|High_Grade_Intraepithelial_Neoplasia	High Grade Glandular Intraepithelial Neoplasia
C7663	High_Grade_Vaginal_Intraepithelial_Neoplasia	High-Grade_Squamous_Intraepithelial_Neoplasia|Vaginal_Intraepithelial_Neoplasia	High Grade Vaginal Intraepithelial Neoplasia|High Grade VAIN
C7664	High_Grade_Vulvar_Intraepithelial_Neoplasia	High-Grade_Squamous_Intraepithelial_Neoplasia|Vulvar_Intraepithelial_Neoplasia	High Grade Vulvar Intraepithelial Neoplasia|High Grade VIN
C7665	Grade_II_Penile_Intraepithelial_Neoplasia	High_Grade_Penile_Intraepithelial_Neoplasia	Grade II Penile Intraepithelial Neoplasia|Grade 2 Penile Intraepithelial Neoplasia
C7666	Low_Grade_Penile_Intraepithelial_Neoplasia	Low_Grade_Squamous_Intraepithelial_Neoplasia|Penile_Intraepithelial_Neoplasia	Low Grade Penile Intraepithelial Neoplasia|Grade 1 Penile Intraepithelial Neoplasia|Grade I Penile Intraepithelial Neoplasia
C7667	High_Grade_Penile_Intraepithelial_Neoplasia	High-Grade_Squamous_Intraepithelial_Neoplasia|Penile_Intraepithelial_Neoplasia	High Grade Penile Intraepithelial Neoplasia
C7668	High_Grade_Conjunctival_Intraepithelial_Neoplasia	Conjunctival_Intraepithelial_Neoplasia|High-Grade_Squamous_Intraepithelial_Neoplasia	High Grade Conjunctival Intraepithelial Neoplasia
C7669	High_Grade_Corneal_Intraepithelial_Neoplasia	Corneal_Intraepithelial_Neoplasia|High-Grade_Squamous_Intraepithelial_Neoplasia	High Grade Corneal Intraepithelial Neoplasia
C7670	High_Grade_Cervical_Intraepithelial_Neoplasia	Cervical_Intraepithelial_Neoplasia|High_Grade_Intraepithelial_Neoplasia	High Grade Cervical Intraepithelial Neoplasia
C7673	Cervical_Glandular_Intraepithelial_Neoplasia	Cervical_Glandular_Neoplasm|Cervical_Intraepithelial_Neoplasia|Glandular_Cell_Intraepithelial_Neoplasia	Cervical Glandular Intraepithelial Neoplasia
C7674	Low_Grade_Cervical_Glandular_Intraepithelial_Neoplasia	Cervical_Glandular_Intraepithelial_Neoplasia|Low-Grade_Cervical_Intraepithelial_Neoplasia|Low_Grade_Glandular_Intraepithelial_Neoplasia	Low Grade Cervical Glandular Intraepithelial Neoplasia
C7675	High_Grade_Cervical_Glandular_Intraepithelial_Neoplasia	Cervical_Glandular_Intraepithelial_Neoplasia|High_Grade_Cervical_Intraepithelial_Neoplasia|High_Grade_Glandular_Intraepithelial_Neoplasia	High Grade Cervical Glandular Intraepithelial Neoplasia
C7676	Adenocarcinoma_in_Adenomatous_Polyp	Adenocarcinoma|Carcinoma_in_a_Polyp	Adenocarcinoma in Adenomatous Polyp
C7677	Adenocarcinoma_in_Tubular_Adenoma	Adenocarcinoma_in_Adenomatous_Polyp	Adenocarcinoma in Tubular Adenoma
C7678	Adenocarcinoma_in_situ_in_Adenomatous_Polyp	Adenocarcinoma_in_Adenomatous_Polyp|Adenocarcinoma_in_situ_in_a_Polyp	Adenocarcinoma In Situ in Adenomatous Polyp
C7679	Adenocarcinoma_in_situ_in_Tubular_Adenoma	Adenocarcinoma_in_Tubular_Adenoma|Adenocarcinoma_in_situ_in_Adenomatous_Polyp	Adenocarcinoma In Situ in Tubular Adenoma
C7680	Adenocarcinoma_in_situ_in_a_Polyp	Adenocarcinoma|Carcinoma_in_situ_in_a_Polyp	Adenocarcinoma In Situ in a Polyp
C7681	Carcinoma_in_situ_in_a_Polyp	Carcinoma_in_a_Polyp|Carcinoma_in_situ	Carcinoma In Situ in a Polyp
C7682	Carcinoma_in_a_Polyp	Carcinoma	Carcinoma in a Polyp
C7683	Adenocarcinoma_with_Cartilaginous_and_Osseous_Metaplasia	Adenocarcinoma_with_Metaplasia|Malignant_Mixed_Neoplasm	Adenocarcinoma with Cartilaginous and Osseous Metaplasia
C7684	Adenocarcinoma_with_Osseous_Metaplasia	Adenocarcinoma_with_Cartilaginous_and_Osseous_Metaplasia	Adenocarcinoma with Osseous Metaplasia
C7685	Adenocarcinoma_with_Cartilaginous_Metaplasia	Adenocarcinoma_with_Cartilaginous_and_Osseous_Metaplasia	Adenocarcinoma with Cartilaginous Metaplasia
C7686	Noninfiltrating_Intracystic_Breast_Carcinoma	Retired_Concepts	Noninfiltrating Intracystic Breast Carcinoma	A carcinoma entirely confined to the ducts.  While intraductal (or DCIS) carcinomas can arise at other sites, these terms are universally used to refer to carcinomas of the breast.
C7687	Intracystic_Breast_Carcinoma	Retired_Concepts	Intracystic Breast Carcinoma	A carcinoma entirely confined to the ducts.  While intraductal (or DCIS) carcinomas can arise at other sites, these terms are universally used to refer to carcinomas of the breast.
C7688	Invasive_Ductal_and_Lobular_Carcinoma	Invasive_Mixed_Breast_Carcinoma|Mixed_Lobular_and_Ductal_Breast_Carcinoma	Invasive Ductal and Lobular Carcinoma|Infiltrating Ductal and Lobular Carcinoma|Invasive Duct and Lobular Carcinoma
C7689	Infiltrating_Ductal_and_Lobular_Carcinoma_in_situ	Invasive_Ductal_and_Lobular_Carcinoma	Invasive Ductal and Lobular Carcinoma In Situ|Infiltrating Ductal and Lobular Carcinoma in situ|LCIS and Infiltrating Ductal Carcinoma|Lobular Carcinoma in situ and Infiltrating Ductal Carcinoma|Lobular Carcinoma in situ and Invasive Ductal Carcinoma
C7690	Intraductal_and_Lobular_Carcinoma	Mixed_Lobular_and_Ductal_Breast_Carcinoma	Intraductal and Lobular Carcinoma
C7691	Resectable_Hepatocellular_Carcinoma	Hepatocellular_Carcinoma	Resectable Hepatocellular Carcinoma|Hepatocellular Carcinoma, Resectable|Resectable Carcinoma of Liver Cell|Resectable Carcinoma of the Liver Cell|Resectable Hepatoma|Resectable Liver Cell Carcinoma
C7692	Resectable_Hepatic_Malignant_Neoplasm	Hepatic_Disorder|Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm	Resectable Hepatic Malignant Neoplasm|Resectable Malignant Neoplasm of Liver
C7693	Precancerous_Atypia	Atypia	Precancerous Atypia|Premalignant Atypia
C7694	Cervical_Precancerous_Atypia	Cervical_Atypia|Precancerous_Atypia	Cervical Precancerous Atypia|Cervical Premalignant Atypia
C7695	Primary_Serous_Papillary_Carcinoma_of_Peritoneum	Serous_Surface_Papillary_Carcinoma	Primary Serous Papillary Carcinoma of Peritoneum
C7696	Stage_IV_Inflammatory_Breast_Carcinoma	Inflammatory_Breast_Carcinoma|Stage_IV_Breast_Cancer	Stage IV Inflammatory Breast Carcinoma|Inflammatory Carcinoma of Breast Stage IV|Stage IV Inflammatory Breast Cancer	A rare type of breast cancer in which breast cancer cells block the lymph vessels in the skin of the breast. The breast becomes red, swollen, and warm, and the skin of the breast may appear pitted or have ridges.
C7698	Nicotine_Withdrawal	Withdrawal_Syndrome	Nicotine Withdrawal
C7699	Gastric_Adenoma	Adenomatous_Polyp|Gastric_Neoplasm|Gastric_Polyp|Gastrointestinal_Adenoma	Gastric Adenoma|Adenoma of Stomach|Adenoma of the Stomach|Adenomatous Polyp of Stomach|Adenomatous Polyp of the Stomach|Gastric Adenomatous Polyp	These are circumscribed lesions, composed of tubular and/or villous structures showing intraepithelial neoplasia.  The frequency of malignant transformation depends on the size and the histological grade.  It occurs in approximately 25% of lesions measuring <2 cm and in 40-50% of lesions >2 cm.  Gastric adenomas are classified as tubular, tubulovillous, and villous. -- 2003
C7700	Ovarian_Adenocarcinoma	Adenocarcinoma|Common_Carcinoma|Ovarian_Carcinoma	Ovarian Adenocarcinoma|Adenocarcinoma of Ovary|Adenocarcinoma of the Ovary	Ovarian adenocarcinoma is the most common type of ovarian carcinoma.  It includes the serous and mucinous adenocarcinomas, the clear cell adenocarcinoma and the endometrioid adenocarcinoma. --2002
C7701	Reactive_Lymphocyte_Count	Retired_Concepts	Reactive Lymphocyte Count|Atypical Lymphocyte Count
C7702	Adult_Hodgkin_s_Lymphoma	Adult_Lymphoma|Hodgkin_s_Lymphoma	Adult Hodgkin's Lymphoma|Adult HD|Adult Hodgkin Lymphoma|Adult Hodgkin's Disease|Adult Hodgkins Disease|Adult Hodgkins Lymphoma	Hodgkin's lymphoma occuring in adults.
C7703	Childhood_Brain_Neoplasm	Brain_Neoplasm|Childhood_Central_Nervous_System_Neoplasm	Childhood Brain Neoplasm|Brain Neoplasms, Childhood|Childhood Brain Tumor|Childhood Neoplasm of Brain|Childhood Neoplasm of the Brain|Childhood Tumor of Brain|Childhood Tumor of the Brain|Pediatric Brain Neoplasm|Pediatric Brain Tumor|Pediatric Neoplasm of Brain|Pediatric Neoplasm of the Brain|Pediatric Tumor of Brain|Pediatric Tumor of the Brain	An abnormal growth of the cells that comprise the tissues of the brain in a person less than twenty one years old. This term does not specify whether the growth is benign or malignant nor does it specify location.
C7704	Adult_Non-Hodgkin_s_Lymphoma	Adult_Lymphoma|Non-Hodgkin_s_Lymphoma	Adult Non-Hodgkin's Lymphoma|Adult NHL|Adult Non-Hodgkin Lymphoma	Non-Hodgkin's lymphoma occuring in adults.
C7705	Childhood_Rhabdomyosarcoma	Childhood_Soft_Tissue_Sarcoma|Rhabdomyosarcoma	Childhood Rhabdomyosarcoma|Pediatric Rhabdomyosarcoma	Rhabdomyosarcoma occuring in childhood.
C7706	Childhood_Non-Hodgkin_s_Lymphoma	Childhood_Lymphoma|Non-Hodgkin_s_Lymphoma	Childhood Non-Hodgkin's Lymphoma|Childhood Non-Hodgkin Lymphoma|Pediatric Non-Hodgkin Lymphoma|Pediatric Non-Hodgkin's Lymphoma	Non-Hodgkin's lymphoma occuring in childhood.
C7707	Adult_Soft_Tissue_Sarcoma	Soft_Tissue_Sarcoma	Adult Soft Tissue Sarcoma|Adult Sarcoma of Soft Tissue|Adult Sarcoma of the Soft Tissue	Soft tissue sarcoma occuring in adults.
C7708	Childhood_Liver_Cancer	Childhood_Hepatic_Neoplasm|Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Infrequent_Neoplasm|Malignant_Childhood_Neoplasm|Primary_Malignant_Neoplasm_of_Liver	Childhood Liver Cancer|Childhood Cancer of Liver|Childhood Cancer of the Liver|Pediatric Cancer of Liver|Pediatric Cancer of the Liver|Pediatric Liver Cancer	Hepatoblastoma or hepatocellular carcinoma developed in childhood.
C7709	Gastrointestinal_Carcinoid_Tumor	Carcinoid_Tumor|Common_Carcinoma|Gastrointestinal_Neuroendocrine_Neoplasm	Gastrointestinal Carcinoid Tumor|Carcinoid Neoplasm of Digestive Tract|Carcinoid Neoplasm of GI Tract|Carcinoid Neoplasm of Gastrointestinal Tract|Carcinoid Neoplasm of the Digestive Tract|Carcinoid Neoplasm of the GI Tract|Carcinoid Neoplasm of the Gastrointestinal Tract|Carcinoid Tumor of Digestive Tract|Carcinoid Tumor of GI Tract|Carcinoid Tumor of Gastrointestinal Tract|Carcinoid Tumor of the Digestive Tract|Carcinoid Tumor of the GI Tract|Carcinoid Tumor of the Gastrointestinal Tract|Common Neuroendocrine Tumor|Digestive Carcinoid Neoplasm|Digestive Carcinoid Tumor|Digestive Tract Carcinoid Neoplasm|Digestive Tract Carcinoid Tumor|GCT|GI Carcinoid Neoplasm|GI Carcinoid Tumor|Gastrointestinal Carcinoid Neoplasm|Gastrointestinal Tract Carcinoid Neoplasm|Gastrointestinal Tract Carcinoid Tumor	A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract; approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell.
C7710	Adult_Brain_Neoplasm	Adult_Intracranial_Neoplasm|Brain_Neoplasm	Adult Brain Neoplasm|Adult Brain Tumor|Brain Neoplasms, Adult|Neoplasm of Adult Brain|Neoplasm of the Adult Brain|Tumor of Adult Brain|Tumor of the Adult Brain	An abnormal growth of the cells that comprise the tissues of the brain. This term does not specify whether the growth is benign or malignant nor does it specify location. It is limited to persons aged greater than twenty one years.
C7711	Adult_Liver_Carcinoma	Hepatic_Disorder|Liver_and_Intrahepatic_Biliary_Tract_Carcinoma	Adult Liver Carcinoma|Adult Primary Cancer of Liver|Adult Primary Cancer of the Liver|Adult Primary Liver Cancer|Adult Primary Liver Carcinoma
C7712	Uveal_Melanoma	Ocular_Melanoma	Uveal Melanoma|Intraocular Melanoma|Melanoma of Uvea|Melanoma of the Uvea|intraocular melanoma	A malignant neoplasm that arises from the pigmented cells of the uveal tract of the eye.  The peak incidence of this tumor is in the 6th decade of life and they are most frequent in caucasians.  Clinically the lesions may present with visual loss or be identified during routine ocular examination.  They may be locally invasive or metastasize to distant sites.  Histologically, ocular melanomas are characterized by spindle cells featuring elongated nuclei and minimal cytoplasm or epithelioid cells which are pleomorphic, have enlarged nuclei and prominent cytoplasm. The later may be referred to as "non-spindle cell" melanomas. (From: Cancer Control; JMCC 5(4):299-309, 1998)
C7713	Squamous_Cell_Carcinoma_Metastatic_to_the_Neck_with_Occult_Primary	Metastatic_Neoplasm_to_the_Neck|Metastatic_Squamous_Cell_Carcinoma	Squamous Cell Carcinoma Metastatic to the Neck with Occult Primary|Epidermoid Cancer Metastatic to the Neck with Occult Primary|Metastatic Epidermoid Neck Cancer with Occult Primary|Metastatic Squamous Cell Neck Cancer with Occult Primary|Metastatic Squamous Neck Cancer with Occult Primary|Squamous Cell Cancer Metastatic to Neck, with Occult Primary|Squamous Cell Cancer Metastatic to the Neck with Occult Primary
C7714	Childhood_Hodgkin_s_Lymphoma	Childhood_Lymphoma|Hodgkin_s_Lymphoma	Childhood Hodgkin's Lymphoma|Childhood HD|Childhood Hodgkin Lymphoma|Childhood Hodgkin's Disease|Childhood Hodgkins Disease|Childhood Hodgkins Lymphoma|Pediatric HD|Pediatric Hodgkin's Disease|Pediatric Hodgkin's Lymphoma	Hodgkin's lymphoma occuring in childhood.
C7715	Childhood_Soft_Tissue_Sarcoma	Malignant_Childhood_Neoplasm|Soft_Tissue_Sarcoma	Childhood Soft Tissue Sarcoma|Childhood Sarcoma of Soft Tissue|Childhood Sarcoma of the Soft Tissue|Pediatric Sarcoma of Soft Tissue|Pediatric Sarcoma of the Soft Tissue|Pediatric Soft Tissue Sarcoma	Soft tissue sarcoma occuring in childhood.
C7716	Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter	Renal_Pelvis_and_Ureter_Carcinoma|Urothelial_Transitional_Cell_Carcinoma	Renal Pelvis and Ureter Urothelial Carcinoma|Renal Pelvis and Ureter TCC|Renal Pelvis and Ureter Transitional Cell Cancer|Renal Pelvis and Ureter Transitional Cell Carcinoma|TCC of Renal Pelvis and Ureter|TCC of the Renal Pelvis and Ureter|Transitional Cell Cancer of Renal Pelvis and Ureter|Transitional Cell Cancer of the Renal Pelvis and Ureter|Transitional Cell Carcinoma of Renal Pelvis and Ureter|Urothelial Carcinoma of the Renal Pelvis and Ureter
C7717	Malignant_Pericardial_Effusion	Pericardial_Effusion	Malignant Pericardial Effusion	Presence of fluid in the pericardial space as a complication of malignant disease.
C7718	Appendix_Adenocarcinoma	Adenocarcinoma|Appendix_Carcinoma	Appendix Adenocarcinoma|Adenocarcinoma of Appendix|Adenocarcinoma of the Appendix|Appendiceal Adenocarcinoma
C7719	Bartholin_s_Gland_Adenocarcinoma	Bartholin_s_Gland_Carcinoma|Vulvar_Adenocarcinoma	Bartholin's Gland Adenocarcinoma|Adenocarcinoma of Bartholin's Gland|Adenocarcinoma of the Bartholin's Gland
C7720	Gallbladder_Adenoma	Adenomatous_Polyp|Gallbladder_Neoplasm|Gallbladder_Polyp|Gastrointestinal_Adenoma	Gallbladder Adenoma|Adenoma of Gallbladder|Adenoma of the Gallbladder
C7721	Gingival_Carcinoma	Malignant_Gingival_Neoplasm|Oral_Cavity_Carcinoma	Gingival Carcinoma|Carcinoma of Gingiva|Carcinoma of Gum|Carcinoma of the Gingiva|Carcinoma of the Gum|Gum Carcinoma
C7722	Cardiac_Fibroma	Retired_Concepts	Cardiac Fibroma|Heart Fibroma
C7723	Cardiac_Sarcoma	Malignant_Cardiac_Neoplasm|Soft_Tissue_Sarcoma	Cardiac Sarcoma|Heart Sarcoma|Sarcoma of Heart|Sarcoma of the Heart
C7724	Small_Intestinal_Carcinoma	Carcinoma|Malignant_Small_Intestinal_Neoplasm	Small Intestinal Carcinoma|Cancer of Small Bowel|Cancer of the Small Bowel|Carcinoma of Small Bowel|Carcinoma of Small Intestine|Carcinoma of the Small Bowel|Carcinoma of the Small Intestine|Small Bowel Carcinoma|Small Intestine Cancer
C7725	Small_Intestinal_Leiomyoma	Benign_Small_Intestinal_Neoplasm|Leiomyoma	Small Intestinal Leiomyoma|Leiomyoma of Small Bowel|Leiomyoma of Small Intestine|Leiomyoma of the Small Bowel|Leiomyoma of the Small Intestine|Leiomyoma, Small Bowel|Leiomyoma, Small Intestine|Small Bowel Leiomyoma|Small Intestine Leiomyoma
C7726	Renal_Fibrosarcoma	Renal_Sarcoma|Soft_Tissue_Fibrosarcoma	Renal Fibrosarcoma|Fibrosarcoma of Kidney|Fibrosarcoma of the Kidney|Kidney Fibrosarcoma
C7727	Light_Chain_Deposition_Disease	Monoclonal_Immunoglobulin_Deposition_Disease	Light Chain Deposition Disease|Light Chain Disease	A condition in which plasma cells secrete immunoglobulin light chains of only one type, kappa or lambda. Light chain deposition disease is often associated with multiple myeloma or lymphoproliferative disease, but as many as 50% of patients have no evidence of neoplastic plasma cell proliferation. Light chains excreted in the urine are known as Bence Jones protein. Amyloidosis and severe renal failure occur more frequently than in multiple myeloma. Also known as Bence Jones myeloma. L-chain disease, L-chain myeloma, and LCDD. --2004
C7728	Scrotal_Paget_s_Disease	Extramammary_Paget_s_Disease|Scrotal_Carcinoma	Paget's Disease of the Scrotum|Paget's Disease of Scrotum|Scrotal Paget's Disease
C7729	Squamous_Cell_Carcinoma_of_the_Penis	Penile_Carcinoma|Squamous_Cell_Carcinoma	Squamous Cell Carcinoma of the Penis|Epidermoid Carcinoma of Penis|Epidermoid Carcinoma of the Penis|Epidermoid Cell Carcinoma of Penis|Epidermoid Cell Carcinoma of the Penis|Penile Epidermoid Carcinoma|Penile Epidermoid Cell Carcinoma|Penile Squamous Cell Carcinoma|Squamous Cell Carcinoma of Penis
C7730	Penile_Sarcoma	Malignant_Penile_Neoplasm|Soft_Tissue_Sarcoma	Penile Sarcoma|Sarcoma of Penis|Sarcoma of the Penis
C7731	Prostate_Sarcoma	Malignant_Prostate_Neoplasm|Soft_Tissue_Sarcoma	Prostate Sarcoma|Sarcoma of Prostate|Sarcoma of the Prostate
C7732	Renal_Pelvis_Squamous_Cell_Carcinoma	Renal_Pelvis_Carcinoma|Squamous_Cell_Carcinoma	Renal Pelvis Squamous Cell Carcinoma|Epidermoid Carcinoma of Kidney Pelvis|Epidermoid Carcinoma of Renal Pelvis|Epidermoid Carcinoma of the Kidney Pelvis|Epidermoid Carcinoma of the Renal Pelvis|Kidney Pelvis Epidermoid Carcinoma|Kidney Pelvis Squamous Cell Carcinoma|Renal Pelvis Epidermoid Carcinoma|Squamous Cell Carcinoma of Kidney Pelvis|Squamous Cell Carcinoma of Renal Pelvis|Squamous Cell Carcinoma of the Kidney Pelvis|Squamous Cell Carcinoma of the Renal Pelvis
C7733	Testicular_Choriocarcinoma	Choriocarcinoma|Malignant_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Testicular_Trophoblastic_Neoplasm	Testicular Choriocarcinoma|Choriocarcinoma of Testis|Choriocarcinoma of the Testis|Malignant Trophoblastic Teratoma	This entity, which represents the rarest of the testicular germ cell tumors, is histologically characterized by syncytiotrophoblasts and cytotrophoblasts.
C7734	Tongue_Lipoma	Benign_Tongue_Neoplasm|Lipoma	Tongue Lipoma|Lipoma of Tongue|Lipoma of the Tongue
C7735	Vaginal_Clear_Cell_Adenocarcinoma	Clear_Cell_Adenocarcinoma|Vaginal_Adenocarcinoma	Vaginal Clear Cell Adenocarcinoma|Clear Cell Adenocarcinoma of Vagina|Clear Cell Adenocarcinoma of the Vagina|Vagina Clear Cell Adenocarcinoma	A morphologic variant of adenocarcinoma affecting the vagina characterized by the presence of malignant glandular epithelium and clear cells containing glycogen.
C7736	Vaginal_Squamous_Cell_Carcinoma	Squamous_Cell_Carcinoma|Vaginal_Carcinoma|Vaginal_Squamous_Neoplasm	Vaginal Squamous Cell Carcinoma|Epidermoid Carcinoma of Vagina|Epidermoid Carcinoma of the Vagina|Epidermoid Cell Carcinoma of Vagina|Epidermoid Cell Carcinoma of the Vagina|Squamous Cell Carcinoma of Vagina|Squamous Cell Carcinoma of the Vagina|Vagina Epidermoid Carcinoma|Vagina Epidermoid Cell Carcinoma|Vagina Squamous Cell Carcinoma|Vaginal Epidermoid Carcinoma|Vaginal Epidermoid Cell Carcinoma
C7737	Vaginal_Sarcoma	Malignant_Vaginal_Neoplasm|Soft_Tissue_Sarcoma|Vaginal_Soft_Tissue_Neoplasm	Vaginal Sarcoma|Sarcoma of Vagina|Sarcoma of the Vagina|Vagina Sarcoma
C7739	Brain_Hemangioma	Benign_Brain_Neoplasm|Intracranial_Hemangioma	Brain Hemangioma|Brain Angioma
C7740	Peau_d_orange	Integumentary_System_Signs_and_Symptoms	Peau d'orange|peau d'orange	A dimpled condition of the skin of the breast, resembling the skin of an orange, sometimes found in inflammatory breast cancer.
C7741	Gastrointestinal_Hemangioma	Benign_Gastrointestinal_Neoplasm|Hemangioma	Gastrointestinal Hemangioma|Angioma of Digestive System|Angioma of Digestive Tract|Angioma of Gastrointestinal System|Angioma of Gastrointestinal Tract|Angioma of the Digestive System|Angioma of the Digestive Tract|Angioma of the Gastrointestinal System|Angioma of the Gastrointestinal Tract|Digestive Angioma|Digestive Hemangioma|Digestive System Angioma|Digestive System Hemangioma|Digestive Tract Angioma|Digestive Tract Hemangioma|Gastrointestinal Angioma|Gastrointestinal System Angioma|Gastrointestinal System Hemangioma|Gastrointestinal Tract Angioma|Gastrointestinal Tract Hemangioma|Hemangioma of Digestive System|Hemangioma of Digestive Tract|Hemangioma of Gastrointestinal System|Hemangioma of Gastrointestinal Tract|Hemangioma of the Digestive System|Hemangioma of the Digestive Tract|Hemangioma of the Gastrointestinal System|Hemangioma of the Gastrointestinal Tract
C7742	Squamous_Papilloma_of_the_Larynx	Benign_Laryngeal_Neoplasm|Squamous_Cell_Papilloma	Squamous Papilloma of the Larynx|Laryngeal Papilloma|Larynx Papilloma|Papilloma of Larynx|Papilloma of the Larynx|Squamous Papilloma of Larynx
C7743	Mouth_Mucous_Membrane_Leukoplakia	Mucous_Membrane_Leukoplakia|Oral_Cavity_Leukoplakia	Mouth Mucous Membrane Leukoplakia
C7744	Mucous_Membrane_Hemangioma	Hemangioma	Mucous Membrane Hemangioma
C7745	Mucous_Membrane_Leukoplakia	Leukoplakia	Mucous Membrane Leukoplakia
C7746	Scrotal_Cyst	Cyst	Scrotal Cyst|Cyst of Scrotum|Cyst of the Scrotum
C7747	Lung_Hemangioma	Retired_Concepts	Lung Hemangioma|Angioma of Lung|Angioma of the Lung|Hemangioma of Lung|Hemangioma of the Lung|Lung Angioma|Pulmonary Hemangioma
C7748	Endocardial_Myxoma	Benign_Endocardial_Neoplasm|Myxoma	Cardiac Myxoma|Endocardial Myxoma|Endocardium, Myxoma|Myxoma of Endocardium|Myxoma of the Endocardium
C7749	Cutaneous_Fibrohistiocytic_Neoplasm	Dermal_Neoplasm	Cutaneous Fibrohistiocytic Neoplasm
C7751	Angiokeratoma_Circumscriptum	Skin_Angiokeratoma	Angiokeratoma Circumscriptum
C7752	Scrotal_Angiokeratoma	Skin_Angiokeratoma	Scrotal Angiokeratoma|Angiokeratoma of Fordyce|Angiokeratoma of Scrotum|Angiokeratoma of the Scrotum|Fordyce Angiokeratoma|Fordyce-Type Angiokeratoma of Scrotum|Fordyce-Type Angiokeratoma of the Scrotum|Scrotal Fordyce-Type Angiokeratoma
C7753	Malignant_Pericarditis	Malignant_Pericardial_Neoplasm|Pericarditis	Malignant Pericarditis|Pericarditis, Malignant
C7754	Juvenile_Polyposis_Syndrome	Hereditary_Neoplastic_Syndrome|Polyposis	Juvenile Polyposis Syndrome|Juvenile Multiple Polyps Syndrome|Juvenile Polyposis
C7755	Peutz-Jeghers_Polyp_of_the_Small_Intestine	Peutz-Jeghers_Polyp|Small_Intestinal_Polyp	Peutz-Jeghers Polyp of the Small Intestine|Peutz-Jeghers Hamartoma of Small Bowel|Peutz-Jeghers Hamartoma of Small Intestine|Peutz-Jeghers Hamartoma of the Small Bowel|Peutz-Jeghers Hamartoma of the Small Intestine|Peutz-Jeghers Harmatoma of Small Intestine|Peutz-Jeghers Harmatoma of the Small Intestine|Peutz-Jeghers Polyp of Small Intestine|Peutz-Jeghers Small Bowel Hamartoma|Peutz-Jeghers Small Intestine Hamartoma
C7756	Squamous_Metaplasia_of_Rectal_Mucosa	Squamous_Metaplasia	Squamous Metaplasia of Rectal Mucosa
C7757	DNA_Repair_Disorder	Genetic_Disorder	DNA Repair Disorder|DNA Repair Deficiency
C7758	Prostatic_Squamous_Metaplasia	Squamous_Metaplasia	Prostatic Squamous Metaplasia|Squamous Metaplasia of Prostate|Squamous Metaplasia of the Prostate|Squamous Prostate Metaplasia
C7759	Apocrine_Metaplasia_of_Breast	Apocrine_Metaplasia	Apocrine Metaplasia of Breast
C7760	Extratemporal_Epilepsy	Epilepsy	Extratemporal Epilepsy
C7761	Iris_Implantation_Cyst	Iris_Cyst	Iris Implantation Cyst|Implantation Cyst of Iris|Implantation Cyst of the Iris
C7762	Ciliary_Body_Implantation_Cyst	Ciliary_Body_Cyst	Ciliary Body Implantation Cyst|Implantation Cyst of Ciliary Body|Implantation Cyst of the Ciliary Body
C7763	Hurthle_Cell_Metaplasia_of_Thyroid_Gland	Hurthle_Cell_Metaplasia	Hurthle Cell Metaplasia of Thyroid Gland
C7764	Atypical_Lymphoproliferative_Disorder	Lymphoproliferative_Disorder|Premalignant_Hematologic_Condition	Atypical Lymphoproliferative Disorder|Atypical Lymphoid Hyperplasia
C7765	Osteosclerotic_Myeloma	Plasma_Cell_Myeloma	Osteosclerotic Myeloma
C7766	Stage_III_Colon_Cancer	Colon_Carcinoma|Stage_III_Colorectal_Cancer	Stage III Colon Cancer|AJCC Stage III Colon Cancer|Colon Cancer Stage III|Colon Cancer, Stage III|Dukes C Carcinoma of Colon|Dukes C Carcinoma of the Colon|Dukes C Colon Carcinoma|Dukes C Colonic Carcinoma|Stage III Carcinoma of Colon|Stage III Carcinoma of the Colon|Stage III Colon Carcinoma|Stage III Colonic Carcinoma	Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.) - 2003
C7767	Stage_I_Breast_Cancer	Breast_Carcinoma	Stage I Breast Cancer|Breast Cancer Stage I|Breast Carcinoma Stage I|Stage I Breast Carcinoma|stage I breast cancer	Cancer no bigger than 2 centimeters (about 1 inch) that has not spread outside the breast.
C7768	Stage_II_Breast_Cancer	Breast_Carcinoma	Stage II Breast Cancer|Breast Cancer Stage II|Carcinoma of Breast Stage II|Carcinoma of the Breast Stage II|Stage II Breast Carcinoma|stage II breast cancer	Stage II breast cancer means one of the following: cancer is no larger than 2 centimeters but has spread to the lymph nodes in the armpit (the axillary lymph nodes); cancer is between 2 and 5 centimeters (1 to 2 inches) and may have spread to the lymph nodes in the armpit; cancer is larger than 5 centimeters (2 inches) but has not spread to the lymph nodes in the armpit.
C7769	Stage_III_Breast_Cancer	Breast_Carcinoma	Stage III Breast Cancer|Breast Cancer Stage III|Breast Carcinoma Stage III|Stage III Breast Carcinoma|stage III breast cancer	Stage III is divided into stages IIIA and IIIB. In stage IIIA breast cancer, the cancer (1) is smaller than 5 centimeters (2 inches) and has spread to the lymph nodes in the armpit, which have grown into each other or into other structures and are attached to them; or (2) is larger than 5 centimeters and has spread to the lymph nodes in the armpit.  In stage IIIB breast cancer, the cancer (1) has spread to tissues near the breast (skin, chest wall, including the ribs and the muscles in the chest); or (2) has spread to lymph nodes inside the chest wall along the breast bone.
C7770	Stage_IIIA_Breast_Cancer	Stage_III_Breast_Cancer	Stage IIIA Breast Cancer|Breast Cancer Stage IIIA|Breast Carcinoma Stage IIIA|Stage IIIA Breast Carcinoma|stage IIIA breast cancer	Stage IIIA breast cancer is defined by either of the following: (1) the cancer is smaller than 5 centimeters (2 inches) and has spread to the lymph nodes under the arm, which have grown into each other or into other structures and are attached to them; (2) the cancer is larger than 5 centimeters and has spread to the lymph nodes under the arm.
C7771	Recurrent_Breast_Cancer	Breast_Carcinoma|Recurrent_Carcinoma	Recurrent Breast Cancer|Breast Cancer, Recurrent|Recurrent Breast Carcinoma	The reemergence of cancer in the breast after a period of remission
C7772	Stage_I_Gastric_Cancer	Gastric_Carcinoma	Stage I Gastric Cancer|Carcinoma of Stomach Stage I|Carcinoma of the Stomach Stage I|Gastric Carcinoma Stage I|Gastric Carcinoma, Stage I|Stage I Carcinoma of Stomach|Stage I Carcinoma of the Stomach|Stage I Gastric Carcinoma|Stage I Stomach Carcinoma|Stomach Cancer Stage I|Stomach Carcinoma Stage I|stage I stomach cancer	Cancer that is in the second or third layers of the stomach wall and has not spread to lymph nodes near the cancer, or is in the second layer of the stomach wall and has spread to lymph nodes very close to the tumor.
C7773	Stage_II_Gastric_Cancer	Gastric_Carcinoma	Stage II Gastric Cancer|Carcinoma of Stomach Stage II|Carcinoma of the Stomach Stage II|Gastric Carcinoma Stage II|Gastric Carcinoma, Stage II|Stage II Carcinoma of Stomach|Stage II Carcinoma of the Stomach|Stage II Gastric Carcinoma|Stage II Stomach Cancer|Stage II Stomach Carcinoma|Stomach Cancer Stage II|Stomach Carcinoma Stage II|stage II stomach cancer	Stage II includes: (T1, N2, M0), (T2a/b, N1, M0), (T3, N0, M0).  T1: Tumor invades lamina propria or submucosa. T2: Tumor invades muscularis propria or submucosa.  T2a: Tumor invades muscularis propria.  T2b: Tumor invades subserosa.  T3: Tumor penetrates serosa (visceral peritoneum) without invasion of adjacent structures. N1: Metastasis in 1 to 6 regional lymph nodes. Metastasis in 7 to 15 regional lymph nodes.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C7774	Stage_III_Gastric_Cancer	Gastric_Carcinoma	Stage III Gastric Cancer|Carcinoma of Stomach Stage III|Carcinoma of the Stomach Stage III|Gastric Carcinoma Stage III|Gastric Carcinoma, Stage III|Stage III Carcinoma of Stomach|Stage III Carcinoma of the Stomach|Stage III Gastric Carcinoma|Stage III Stomach Cancer|Stage III Stomach Carcinoma|Stomach Cancer Stage III|Stomach Carcinoma Stage III|stage III stomach cancer	Stage III includes: IIIA (T2a/b, N2, M0); (T3, N1, M0); (T4, N0, M0).  IIIB: (T3, N2, M0).  N0: No regional lymph node metastasis. N1: Metastasis in 1 to 6 regional lymph nodes.  N2: Metastasis in 7 to 15 regional lymph nodes. T2a: Tumor invades muscularis propria.  T2b: Tumor invades subserosa. T3: Tumor penetrates serosa (visceral peritoneum) without invasion of adjacent structures. T4: Tumor invades adjacent structures.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C7775	Stage_II_Anal_Canal_Cancer	Anal_Canal_Carcinoma	Stage II Anal Canal Cancer|Anal Cancer Stage II|Stage II Anal Cancer|Stage II Anal Carcinoma|Stage II Carcinoma of Anus|Stage II Carcinoma of the Anus|stage II anal cancer	Cancer that has spread beyond the top layer of anal tissue and is larger than 2 centimeters (about 1 inch) but has not spread to nearby organs or lymph nodes.
C7776	Stage_III_Anal_Canal_Cancer	Anal_Canal_Carcinoma	Stage III Anal Canal Cancer|Anal Cancer Stage III|Stage III Anal Cancer|Stage III Anal Carcinoma|Stage III Carcinoma of Anus|Stage III Carcinoma of the Anus|stage III anal cancer	Stage III anal cancer is divided into stage IIIA and IIIB. Stage IIIA anal cancer has spread to the lymph nodes around the rectum or to nearby organs such as the vagina or bladder.  Stager IIIB cancer has spread to the lymph nodes in the middle of the abdomen or in the groin, or the cancer has spread to both nearby organs and the lymph nodes around the rectum.
C7777	Stage_II_Non-Small_Cell_Lung_Cancer	Non-Small_Cell_Lung_Carcinoma|Stage_II_Lung_Cancer	Stage II Non-Small Cell Lung Cancer|Non -Small Cell Lung Cancer Stage II|Non Small Cell Lung Cancer Stage II|Stage II Non-Oat Cell Carcinoma of Lung|Stage II Non-Oat Cell Carcinoma of the Lung|Stage II Non-Oat Cell Lung Carcinoma|Stage II Non-Small Cell Carcinoma of Lung|Stage II Non-Small Cell Carcinoma of the Lung|Stage II Non-Small Cell Lung Carcinoma|stage II non-small cell lung cancer	Cancer that has spread to nearby lymph nodes.
C7778	Stage_III_Non-Small_Cell_Lung_Cancer	Non-Small_Cell_Lung_Carcinoma|Stage_III_Lung_Cancer	Stage III Non-Small Cell Lung Cancer|Stage III NSCLC|Stage III Non-Oat Cell Carcinoma of Lung|Stage III Non-Oat Cell Carcinoma of the Lung|Stage III Non-Oat Cell Lung Carcinoma|Stage III Non-Small Cell Carcinoma of Lung|Stage III Non-Small Cell Carcinoma of the Lung|Stage III Non-Small Cell Lung Carcinoma|stage III non-small cell lung cancer	Cancer has spread to structures near the lung; to the lymph nodes in the area that separates the two lungs(mediastinum); or to the lymph nodes on the other side of the chest or in the lower neck. Stage III is further divided into stage IIIA (usually can be resected which is sometimes treated with surgery) and stage IIIB (usually cannot be resected which is rarely treated with surgery).
C7779	Superior_Sulcus_Lung_Carcinoma	Lung_Carcinoma|Malignant_Superior_Sulcus_Neoplasm	Superior Sulcus Lung Carcinoma|Superior Sulcus Carcinoma of Lung|Superior Sulcus Carcinoma of the Lung	A carcinoma originating from the apical lung. Most superior sulcus lung carcinomas are bronchogenic carcinomas. This carcinoma may be associated with Pancoast syndrome. Also known as Pancoast tumor. --2004
C7780	Localized_Osteosarcoma	Osteosarcoma	Localized Osteosarcoma|Localized Osteogenic Sarcoma|Osteosarcoma, Localized	Osteosarcoma localized or limited to a definite location.
C7781	Metastatic_Osteosarcoma	Osteosarcoma	Metastatic Osteosarcoma|Metastatic Osteogenic Sarcoma|Osteosarcoma, Metastatic	Osteosarcoma that has spread to a second site
C7782	Stage_IIIB_Breast_Cancer	Stage_III_Breast_Cancer	Stage IIIB Breast Cancer|Breast Cancer Stage IIIB|Breast Carcinoma Stage IIIB|Stage IIIB Breast Carcinoma|stage IIIB breast cancer	Stage IIIB breast cancer is defined by either of the following: (1) the cancer has spread to tissues near the breast (skin, chest wall, including the ribs and the muscles in the chest); (2) the cancer has spread to lymph nodes inside the chest wall along the breast bone.
C7783	Recurrent_Non-Small_Cell_Lung_Cancer	Non-Small_Cell_Lung_Carcinoma|Recurrent_Lung_Cancer	Recurrent Non-Small Cell Lung Cancer|Non Small Cell Lung Cancer Recurrent|Non Small Cell Lung Cancer, Recurrent|Recurrent NSCLC|Recurrent Non-Small Cell Cancer of Lung|Recurrent Non-Small Cell Cancer of the Lung	The re-emergence of non-small cell lung cancer after a period of remission. (NCI05)
C7784	Recurrent_Childhood_Acute_Lymphoblastic_Leukemia	Childhood_Acute_Lymphoblastic_Leukemia|Relapsed_Hematologic_Malignancy	Recurrent Childhood Acute Lymphoblastic Leukemia|Recurrent Childhood ALL|Recurrent Childhood Acute Lymphocytic Leukemia|Recurrent Childhood Acute Lymphogenous Leukemia|Recurrent Childhood Acute Lymphoid Leukemia|Recurrent Pediatric ALL|Recurrent Pediatric Acute Lymphoblastic Leukemia|Recurrent Pediatric Acute Lymphocytic Leukemia|Recurrent Pediatric Acute Lymphogenous Leukemia|Recurrent Pediatric Acute Lymphoid Leukemia|Relapsed Childhood ALL|Relapsed Childhood Acute Lymphoblastic Leukemia|Relapsed Childhood Acute Lymphocytic Leukemia|Relapsed Pediatric ALL|Relapsed Pediatric Acute Lymphoblastic Leukemia|Relapsed Pediatric Acute Lymphocytic Leukemia|Relapsed Pediatric Acute Lymphogenous Leukemia|Relapsed Pediatric Acute Lymphoid Leukemia
C7785	Stage_I_Pancreatic_Cancer	Pancreatic_Carcinoma	Stage I Pancreatic Cancer|Pancreatic Cancer Stage I|Stage I Carcinoma of Pancreas|Stage I Carcinoma of the Pancreas|Stage I Pancreatic Carcinoma|stage I pancreatic cancer	Cancer that is found only in the pancreas itself or has started to spread to the tissues next to the pancreas (such as the small intestine, the stomach, or the bile duct).
C7786	Stage_II_Pancreatic_Cancer	Pancreatic_Carcinoma	Stage II Pancreatic Cancer|Pancreatic Cancer Stage II|Stage II Carcinoma of Pancreas|Stage II Carcinoma of the Pancreas|Stage II Pancreatic Carcinoma|stage II pancreatic cancer	Cancer that has spread to nearby organs such as the stomach, spleen, or colon but has not entered the lymph nodes.
C7787	Stage_III_Pancreatic_Cancer	Pancreatic_Carcinoma	Stage III Pancreatic Cancer|Pancreatic Cancer Stage III|Stage III Carcinoma of Pancreas|Stage III Carcinoma of the Pancreas|Stage III Pancreatic Carcinoma|stage III pancreatic cancer	Cancer of the pancreas in which the cancer has spread to the lymph nodes near the pancreas. Cancer may have spread to nearby organs.
C7788	Stage_0_Gastric_Cancer	Gastric_Carcinoma|Grade_III_Glandular_Intraepithelial_Neoplasia|High-Grade_Gastric_Intraepithelial_Neoplasia	Stage 0 Gastric Cancer|Carcinoma in situ of Stomach|Carcinoma in situ of the Stomach|Carcinoma of Stomach Stage 0|Carcinoma of the Stomach Stage 0|Gastric Carcinoma Stage 0|Gastric Carcinoma in situ|Gastric Carcinoma, Stage 0|Stage 0 Carcinoma of Stomach|Stage 0 Carcinoma of the Stomach|Stage 0 Gastric Carcinoma|Stage 0 Stomach Cancer|Stage 0 Stomach Carcinoma|Stomach Carcinoma Stage 0|Stomach Carcinoma in situ	Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial tumor without invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C7789	Recurrent_Adult_Hodgkin_s_Lymphoma	Adult_Hodgkin_s_Lymphoma|Recurrent_Hodgkin_s_Lymphoma	Recurrent Adult Hodgkin's Lymphoma|Recurrent Adult Hodgkin Lymphoma|Recurrent Adult Hodgkin's Disease|Relapsed Adult Hodgkin's Disease|Relapsed Adult Hodgkin's Lymphoma
C7790	Stage_I_Rectal_Cancer	Rectal_Carcinoma|Stage_I_Colorectal_Cancer	Stage I Rectal Cancer|AJCC Stage I Rectal Cancer|Dukes A Carcinoma of Rectum|Dukes A Carcinoma of the Rectum|Dukes A Rectal Carcinoma|Rectal Cancer Stage I|Stage I Carcinoma of Rectum|Stage I Carcinoma of the Rectum|Stage I Rectal Carcinoma	Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. (AJCC 6th ed.) -2003
C7791	Stage_II_Rectal_Cancer	Rectal_Carcinoma|Stage_II_Colorectal_Cancer	Stage II Rectal Cancer|AJCC Stage II Rectal Cancer|Dukes B Carcinoma of Rectum|Dukes B Carcinoma of the Rectum|Dukes B Rectal Carcinoma|Rectal Cancer Stage II|Stage II Carcinoma of Rectum|Stage II Carcinoma of the Rectum|Stage II Rectal Carcinoma	Stage II includes IIA (T3, N0, M0) and IIB (T4, N0, M0). T3: Tumor invades through the muscularis propria into the subserosa, or into nonperitonealized pericolic or perirectal tissues. T4: Tumor directly invades other organs or structures, and/or perforates the visceral peritoneum. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C7792	Stage_III_Rectal_Cancer	Rectal_Carcinoma|Stage_III_Colorectal_Cancer	Stage III Rectal Cancer|AJCC Stage III Rectal Cancer|Dukes C Carcinoma of Rectum|Dukes C Carcinoma of the Rectum|Dukes C Rectal Carcinoma|Rectal Cancer Stage III|Stage III Carcinoma of Rectum|Stage III Carcinoma of the Rectum|Stage III Rectal Carcinoma	Stage III includes: IIIA (T1-T2, N0, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0).  N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. (AJCC 6th ed.) - 2003
C7793	Recurrent_Anal_Canal_Cancer	Anal_Canal_Carcinoma|Recurrent_Gastrointestinal_System_Cancer	Recurrent Anal Canal Cancer|Recurrent Anal Cancer	Anal cancer with repeated appearances in the patient after a period of remission
C7794	Stage_0_Anal_Canal_Cancer	Anal_Canal_Carcinoma|Gastrointestinal_Carcinoma_in_situ|High_Grade_Anal_Canal_Intraepithelial_Neoplasia	Stage 0 Anal Canal Cancer|Anal Canal Carcinoma in situ|Anal Cancer Stage 0|Anal Carcinoma Stage 0|Anal Carcinoma in situ|Stage 0 Anal Cancer|Stage 0 Anal Carcinoma	Stage 0 anal cancer corresponds to the following TNM grouping: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.) - 2003
C7795	Stage_I_Cutaneous_T-Cell_Lymphoma	Cutaneous_T-Cell_Lymphoma|Stage_I_Mature_T-and_NK-Cell_Lymphoma	Stage I Cutaneous T-Cell Non-Hodgkin's Lymphoma|Cutaneous T-Cell Lymphoma Stage I|Skin T-Cell Lymphoma Stage I|T-Cell Lymphoma of Skin Stage I|T-Cell Lymphoma of the Skin Stage I|stage I cutaneous T-cell lymphoma	May be either of the following: (1) stage IA cancer affecting less than 10% of the skin's surface and appearing as red, dry, scaly patches; (2) stage IB cancer affecting 10% or more of the skin's surface and appearing as red, dry, scaly patches.
C7796	Stage_I_Mycosis_Fungoides	Mycosis_Fungoides|Stage_I_Cutaneous_T-Cell_Lymphoma	Stage I Mycosis Fungoides|Mycosis Fungoides Stage I
C7797	Stage_II_Cutaneous_T-Cell_Lymphoma	Cutaneous_T-Cell_Lymphoma|Stage_II_Mature_T-and_NK-Cell_Lymphoma	Stage II Cutaneous T-Cell Non-Hodgkin's Lymphoma|Cutaneous T-Cell Lymphoma Stage II|Skin T-Cell Lymphoma Stage II|T-Cell Lymphoma of Skin Stage II|T-Cell Lymphoma of the Skin Stage II|stage II cutaneous T-cell lymphoma	Stage II cutaneous T-cell lymphoma may be either of the following: (1) stage IIA, in which the skin has red, dry, scaly patches but no tumors, and lymph nodes are enlarged but do not contain cancer cells; (2) stage IIB, in which tumors are found on the skin, and lymph nodes are enlarged but do not contain cancer cells.
C7798	Stage_II_Mycosis_Fungoides	Mycosis_Fungoides|Stage_II_Cutaneous_T-Cell_Lymphoma	Stage II Mycosis Fungoides|Mycosis Fungoides Stage II
C7799	Stage_III_Cutaneous_T-Cell_Lymphoma	Cutaneous_T-Cell_Lymphoma|Stage_III_Mature_T-and_NK-Cell_Lymphoma	Stage III Cutaneous T-Cell Non-Hodgkin's Lymphoma|Cutaneous T-Cell Lymphoma Stage III|Skin T-Cell Lymphoma Stage III|T-Cell Lymphoma of Skin Stage III|T-Cell Lymphoma of the Skin Stage III|stage III cutaneous T-cell lymphoma	Nearly all of the skin is red, dry, and scaly; lymph nodes are either normal or enlarged but do not contain cancer cells.
C7800	Stage_III_Mycosis_Fungoides	Mycosis_Fungoides|Stage_III_Cutaneous_T-Cell_Lymphoma	Stage III Mycosis Fungoides|Mycosis Fungoides Stage III
C7801	Stage_IV_Cutaneous_T-Cell_Lymphoma	Cutaneous_T-Cell_Lymphoma|Stage_IV_Mature_T-and_NK-Cell_Lymphoma	Stage IV Cutaneous T-Cell Non-Hodgkin's Lymphoma|Cutaneous T-Cell Lymphoma Stage IV|Metastatic Cutaneous T-Cell Lymphoma|Skin T-Cell Lymphoma Stage IV|T-Cell Lymphoma of Skin Stage IV|T-Cell Lymphoma of the Skin Stage IV|stage IV cutaneous T-cell lymphoma	Stage IV cutaneous T-cell lymphoma may be either of the following: in stage IVA cancer, the skin is red, dry, and scaly, and the lymph nodes contain cancer cells; in stage IVB cancer, the skin is red, dry and scaly, cancer cells may be found in lymph nodes, and cancer has spread to other organs in the body.
C7802	Stage_IV_Mycosis_Fungoides	Mycosis_Fungoides|Stage_IV_Cutaneous_T-Cell_Lymphoma	Stage IV Mycosis Fungoides|Metastatic Mycosis Fungoides|Mycosis Fungoides Stage IV
C7803	Stage_II_Cervical_Cancer	Cervical_Carcinoma	Stage II Cervical Cancer|AJCC Stage II Cervical Cancer|Cervical Cancer Stage II|Cervical Carcinoma Stage II|Cervix Cancer Stage II|FIGO Stage II Carcinoma of Cervix|FIGO Stage II Carcinoma of Cervix Uteri|FIGO Stage II Carcinoma of Uterine Cervix|FIGO Stage II Carcinoma of the Cervix|FIGO Stage II Carcinoma of the Cervix Uteri|FIGO Stage II Carcinoma of the Uterine Cervix|FIGO Stage II Cervical Carcinoma|FIGO Stage II Cervix Carcinoma|FIGO Stage II Cervix Uteri Carcinoma|FIGO Stage II Uterine Cervix Carcinoma|Uterine Cervix Cancer Stage II|stage II cancer of the cervix	Cancer that has spread to nearby areas but is still inside the pelvis. In stage IIA cancer of the cervix, cancer has spread beyond the cervix to the upper two thirds of the vagina; in stage IIB, cancer has spread to the tissue around the cervix.
C7804	Recurrent_Cervical_Carcinoma	Cervical_Carcinoma|Recurrent_Female_Reproductive_System_Cancer	Recurrent Cervical Cancer|Cervical Carcinoma Recurrent|Recurrent Carcinoma of Cervix|Recurrent Carcinoma of Cervix Uteri|Recurrent Carcinoma of Uterine Cervix|Recurrent Carcinoma of the Cervix|Recurrent Carcinoma of the Cervix Uteri|Recurrent Carcinoma of the Uterine Cervix|Recurrent Cervix Uteri Carcinoma|Recurrent Uterine Cervix Carcinoma|Relapsed Carcinoma of Cervix|Relapsed Carcinoma of Cervix Uteri|Relapsed Carcinoma of Uterine Cervix|Relapsed Carcinoma of the Cervix|Relapsed Carcinoma of the Cervix Uteri|Relapsed Carcinoma of the Uterine Cervix|Relapsed Cervical Carcinoma|Relapsed Cervix Carcinoma|Relapsed Cervix Uteri Carcinoma|Relapsed Uterine Cervix Carcinoma	The reemerging of cervical carcinoma after a period of remission.
C7805	Recurrent_Cutaneous_T-Cell_Lymphoma	Cutaneous_T-Cell_Lymphoma|Recurrent_Mature_T-and_NK-Cell_Non-Hodgkin_s_Lymphoma	Recurrent Cutaneous T-Cell Non-Hodgkin's Lymphoma|Recurrent Skin T-Cell Lymphoma|Recurrent T-Cell Lymphoma of Skin|Recurrent T-Cell Lymphoma of the Skin|Relapsed Cutaneous T-Cell Lymphoma|Relapsed Skin T-Cell Lymphoma|Relapsed T-Cell Lymphoma of Skin|Relapsed T-Cell Lymphoma of the Skin
C7806	Localized_Ewing_s_Sarcoma	Ewing_s_Sarcoma|Localized_Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor	Localized Ewing's Sarcoma|Ewing's Sarcoma, Localized|Localized Ewing's Tumor	Ewing's sarcoma which has not spread from its initial site.
C7807	Metastatic_Ewing_s_Sarcoma	Ewing_s_Sarcoma|Metastatic_Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor	Metastatic Ewing's Sarcoma|Ewing's Sarcoma, Metastatic	Ewing's sarcoma which has spread from its initial site.
C7808	Recurrent_Ewing_s_Sarcoma	Ewing_s_Sarcoma|Recurrent_Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor	Recurrent Ewing's Sarcoma|Ewing's Sarcoma, Recurrent|Relapsed Ewing's Sarcoma	Ewing's sarcoma which has recurred after treatment and/or remission. While initial complete responses are not uncommon, there is a fair chance of relapse as late as one to two decades after initial therapy.
C7809	Adult_Fibrosarcoma	Fibrosarcoma	Adult Fibrosarcoma	A malignant mesenchymal tumor composed of fibroblasts, and characterized by collagen production and a herringbone architectural pattern.  It is more commonly seen in middle-aged and older adults.  It usually affects the deep soft tissues of extremities, trunk, head and neck.  Adult fibrosarcomas may recur and metastasise to the lungs and bones. -- 2004
C7810	Adult_Leiomyosarcoma	Leiomyosarcoma	Adult Leiomyosarcoma
C7811	Adult_Liposarcoma	Liposarcoma	Adult Liposarcoma
C7812	Solitary_Osseous_Plasmacytoma	Solitary_Plasmacytoma	Solitary Osseous Plasmacytoma|Isolated Osseous Plasmacytoma|Isolated Plasmacytoma of Bone|Solitary Plasmacytoma of Bone	A localized clonal (malignant) plasma cell infiltrate in the bone without peripheral blood involvement.  The most commonly affected bones are the vertebrae, ribs, skull, pelvis and femur.  X-rays examination reveals a solitary lytic lesion. --2003
C7813	Refractory_Plasma_Cell_Neoplasm	Plasma_Cell_Neoplasm|Refractory_Hematologic_Malignancy	Refractory Plasma Cell Neoplasm
C7814	Adult_Malignant_Peripheral_Nerve_Sheath_Tumor	Malignant_Peripheral_Nerve_Sheath_Tumor	Adult Malignant Peripheral Nerve Sheath Tumor|Adult MPNST|Adult Malignant Neoplasm of Peripheral Nerve Sheath|Adult Malignant Neoplasm of the Peripheral Nerve Sheath|Adult Malignant Neurilemmoma|Adult Malignant Peripheral Nerve Sheath Neoplasm|Adult Malignant Schwannoma|Adult Malignant Tumor of Peripheral Nerve Sheath|Adult Malignant Tumor of the Peripheral Nerve Sheath
C7815	Recurrent_Childhood_Rhabdomyosarcoma	Childhood_Rhabdomyosarcoma|Recurrent_Rhabdomyosarcoma	Recurrent Childhood Rhabdomyosarcoma|Recurrent Pediatric Rhabdomyosarcoma|Relapsed Childhood Rhabdomyosarcoma|Relapsed Pediatric Rhabdomyosarcoma
C7816	Childhood_Craniopharyngioma	Childhood_Intracranial_Neoplasm|Craniopharyngioma	Childhood Craniopharyngioma|Benign Childhood Neoplasm of Rathke's Pouch|Benign Childhood Rathke's Pouch Neoplasm|Benign Childhood Rathke's Pouch Tumor|Benign Childhood Tumor of Rathke's Pouch|Benign Pediatric Neoplasm of Rathke's Pouch|Benign Pediatric Rathke's Pouch Neoplasm|Benign Pediatric Rathke's Pouch Tumor|Benign Pediatric Tumor of Rathke's Pouch|Childhood Neoplasm of Rathke's Pouch|Childhood Rathke's Pouch Neoplasm|Childhood Rathke's Pouch Tumor|Childhood Tumor of Rathke's Pouch|Pediatric Craniopharyngioma|Pediatric Neoplasm of Rathke's Pouch|Pediatric Rathke's Pouch Neoplasm|Pediatric Rathke's Pouch Tumor|Pediatric Tumor of Rathke's Pouch
C7817	Adult_Synovial_Sarcoma	Adult_Soft_Tissue_Sarcoma|Synovial_Sarcoma	Adult Synovial Sarcoma
C7818	Stage_I_Adult_Soft_Tissue_Sarcoma	Adult_Soft_Tissue_Sarcoma|Stage_I_Soft_Tissue_Sarcoma	Stage I Adult Soft Tissue Sarcoma|Stage I Adult Sarcoma of Soft Tissue|Stage I Adult Sarcoma of the Soft Tissue
C7819	Stage_II_Adult_Soft_Tissue_Sarcoma	Adult_Soft_Tissue_Sarcoma|Stage_II_Soft_Tissue_Sarcoma	Stage II Adult Soft Tissue Sarcoma|Stage II Adult Sarcoma of Soft Tissue|Stage II Adult Sarcoma of the Soft Tissue
C7820	Stage_III_Adult_Soft_Tissue_Sarcoma	Adult_Soft_Tissue_Sarcoma|Stage_III_Soft_Tissue_Sarcoma	Stage III Adult Soft Tissue Sarcoma|Stage III Adult Sarcoma of Soft Tissue|Stage III Adult Sarcoma of the Soft Tissue
C7821	Stage_IV_Adult_Soft_Tissue_Sarcoma	Adult_Soft_Tissue_Sarcoma|Stage_IV_Soft_Tissue_Sarcoma	Stage IV Adult Soft Tissue Sarcoma|Metastatic Adult Soft Tissue Sarcoma|Stage IV Adult Sarcoma of Soft Tissue|Stage IV Adult Sarcoma of the Soft Tissue
C7822	Recurrent_Adult_Soft_Tissue_Sarcoma	Adult_Soft_Tissue_Sarcoma	Recurrent Adult Soft Tissue Sarcoma|Recurrent Adult Sarcoma of Soft Tissue|Recurrent Adult Sarcoma of the Soft Tissue|Relapsed Adult Sarcoma of Soft Tissue|Relapsed Adult Sarcoma of the Soft Tissue|Relapsed Adult Soft Tissue Sarcoma
C7823	Stage_I_Renal_Cell_Cancer	Renal_Cell_Carcinoma	Stage I Renal Cell Cancer|Renal Cell Cancer Stage I|Renal Cell Carcinoma, Stage I|Stage I Renal Cell Carcinoma|stage I kidney cancer	A tumor that is 7 centimeters (2.75 inches) or smaller.
C7824	Stage_II_Renal_Cell_Cancer	Renal_Cell_Carcinoma	Stage II Renal Cell Cancer|Renal Cell Cancer Stage II|Renal Cell Carcinoma, Stage II|Stage II Renal Cell Carcinoma|stage II kidney cancer	Stage 2 includes T2, N0, M0.  T2: Tumor more than 7 cm in greatest dimension limited to the kidney.  N0: No regional lymph node metastases.  M0: No distant metastasis. (AJCC 6th Ed.) - 2003
C7825	Recurrent_Renal_Cell_Carcinoma	Recurrent_Urinary_Tract_Cancer|Renal_Cell_Carcinoma	Recurrent Renal Cell Carcinoma|Relapsed Renal Cell Carcinoma|Renal Cell Carcinoma, Recurrent	A reemergence of renal cell carcinoma after a period of remission.
C7826	Localized_Parathyroid_Carcinoma	Localized_Carcinoma|Parathyroid_Carcinoma	Localized Parathyroid Gland Carcinoma|Localized Parathyroid Cancer|Localized Parathyroid Carcinoma	A parathyroid gland carcinoma that has not spread to other anatomic sites. (NCI05)
C7827	Metastatic_Parathyroid_Neoplasm	Malignant_Parathyroid_Neoplasm	Metastatic Malignant Parathyroid Gland Neoplasm|Metastatic Neoplasm of Parathyroid|Metastatic Neoplasm of Parathyroid Gland|Metastatic Neoplasm of the Parathyroid|Metastatic Neoplasm of the Parathyroid Gland|Metastatic Parathyroid Gland Neoplasm|Metastatic Parathyroid Gland Tumor|Metastatic Parathyroid Neoplasm|Metastatic Parathyroid Tumor|Metastatic Tumor of Parathyroid|Metastatic Tumor of Parathyroid Gland|Metastatic Tumor of the Parathyroid|Metastatic Tumor of the Parathyroid Gland	A malignant neoplasm arising from the parathyroid glands that has spread to other anatomic sites. (NCI05)
C7828	Recurrent_Parathyroid_Carcinoma	Parathyroid_Carcinoma|Recurrent_Head_and_Neck_Cancer	Recurrent Parathyroid Gland Carcinoma|Recurrent Parathyroid Cancer|Recurrent Parathyroid Carcinoma	The reemergence of parathyroid gland carcinoma after a period of remission. (NCI05)
C7829	Stage_I_Ovarian_Cancer	Ovarian_Carcinoma	Stage I Ovarian Cancer|AJCC Stage I Ovarian Cancer|FIGO Stage I Cancer of Ovary|FIGO Stage I Cancer of the Ovary|FIGO Stage I Carcinoma of Ovary|FIGO Stage I Carcinoma of the Ovary|FIGO Stage I Ovarian Cancer|FIGO Stage I Ovarian Carcinoma|Ovarian Cancer Stage I|Stage I Ovarian Carcinoma|stage I ovarian cancer	Cancer that is found in one or both of the ovaries and has not spread.
C7830	Stage_II_Ovarian_Cancer	Ovarian_Carcinoma	Stage II Ovarian Cancer|AJCC Stage II Ovarian Cancer|FIGO Stage II Cancer of Ovary|FIGO Stage II Cancer of the Ovary|FIGO Stage II Carcinoma of Ovary|FIGO Stage II Carcinoma of the Ovary|FIGO Stage II Ovarian Cancer|FIGO Stage II Ovarian Carcinoma|Ovarian Cancer Stage II|Stage II Ovarian Carcinoma|stage II ovarian cancer	Cancer that is found in one or both ovaries and/or has spread to one of more of the following: uterus, fallopian tubes, other body parts within the pelvis.
C7831	Stage_III_Ovarian_Cancer	Ovarian_Carcinoma	Stage III Ovarian Cancer|AJCC Stage III Ovarian Cancer|FIGO Stage III Cancer of Ovary|FIGO Stage III Cancer of the Ovary|FIGO Stage III Carcinoma of Ovary|FIGO Stage III Carcinoma of the Ovary|FIGO Stage III Ovarian Cancer|FIGO Stage III Ovarian Carcinoma|Ovarian Cancer Stage III|Stage III Ovarian Carcinoma|stage III ovarian cancer	Cancer is found in one or both ovaries and has spread to lymph nodes or to other body parts inside the abdomen (such as the surface of the liver or intestine).
C7832	Stage_IV_Ovarian_Cancer	Ovarian_Carcinoma	Stage IV Ovarian Cancer|AJCC Stage IV Ovarian Cancer|FIGO Stage IV Cancer of Ovary|FIGO Stage IV Cancer of the Ovary|FIGO Stage IV Carcinoma of Ovary|FIGO Stage IV Carcinoma of the Ovary|FIGO Stage IV Ovarian Cancer|FIGO Stage IV Ovarian Carcinoma|Ovarian Cancer Stage IV|Stage IV Ovarian Carcinoma|stage IV ovarian cancer	Cancer is found in one or both ovaries and has spread outside the abdomen or has spread to the inside of the liver.
C7833	Recurrent_Ovarian_Cancer	Ovarian_Carcinoma|Recurrent_Female_Reproductive_System_Cancer	Recurrent Ovarian Cancer|Recurrent Carcinoma of Ovary|Recurrent Carcinoma of the Ovary|Recurrent Epithelial Cancer of Ovary|Recurrent Epithelial Cancer of the Ovary|Recurrent Ovarian Carcinoma|Recurrent Ovarian Epithelial Cancer|Relapsed Carcinoma of Ovary|Relapsed Carcinoma of the Ovary|Relapsed Epithelial Cancer of Ovary|Relapsed Epithelial Cancer of the Ovary|Relapsed Ovarian Carcinoma|Relapsed Ovarian Epithelial Cancer	The reemergence of ovarian epithelial cancer after a period of remission
C7834	Recurrent_Childhood_Brain_Neoplasm	Childhood_Brain_Neoplasm|Recurrent_Childhood_Central_Nervous_System_Neoplasm	Recurrent Childhood Brain Neoplasm|Recurrent Childhood Brain Tumor|Recurrent Neoplasm of Childhood Brain|Recurrent Neoplasm of Pediatric Brain|Recurrent Neoplasm of the Childhood Brain|Recurrent Neoplasm of the Pediatric Brain|Recurrent Pediatric Brain Neoplasm|Recurrent Pediatric Brain Tumor|Recurrent Tumor of Childhood Brain|Recurrent Tumor of Pediatric Brain|Recurrent Tumor of the Childhood Brain|Recurrent Tumor of the Pediatric Brain|Relapsed Childhood Brain Neoplasm|Relapsed Childhood Brain Tumor|Relapsed Neoplasm of Childhood Brain|Relapsed Neoplasm of Pediatric Brain|Relapsed Neoplasm of the Childhood Brain|Relapsed Neoplasm of the Pediatric Brain|Relapsed Pediatric Brain Neoplasm|Relapsed Pediatric Brain Tumor|Relapsed Tumor of Childhood Brain|Relapsed Tumor of Pediatric Brain|Relapsed Tumor of the Childhood Brain|Relapsed Tumor of the Pediatric Brain
C7835	Localized_Resectable_Neuroblastoma	Neuroblastoma	Localized Resectable Neuroblastoma
C7836	Regional_Neuroblastoma	Neuroblastoma	Regional Neuroblastoma
C7837	Recurrent_Neuroblastoma	Neuroblastoma	Recurrent Neuroblastoma|Relapsed Neuroblastoma
C7838	Stage_IV_Childhood_Hepatocellular_Carcinoma	Childhood_Hepatocellular_Carcinoma|Stage_IV_Hepatocellular_Carcinoma	Stage IV Childhood Hepatocellular Carcinoma|Stage IV Childhood Hepatoma|Stage IV Childhood Liver Cell Carcinoma|Stage IV Pediatric Hepatocellular Carcinoma|Stage IV Pediatric Hepatoma|Stage IV Pediatric Liver Cell Carcinoma
C7839	Recurrent_Childhood_Liver_Cancer	Childhood_Liver_Cancer	Recurrent Childhood Liver Cancer|Recurrent Childhood Cancer of Liver|Recurrent Childhood Cancer of the Liver|Recurrent Pediatric Cancer of Liver|Recurrent Pediatric Cancer of the Liver|Recurrent Pediatric Liver Cancer|Relapsed Childhood Cancer of Liver|Relapsed Childhood Cancer of the Liver|Relapsed Childhood Liver Cancer|Relapsed Pediatric Cancer of Liver|Relapsed Pediatric Cancer of the Liver|Relapsed Pediatric Liver Cancer
C7840	Stage_I_Wilms_Tumor	Renal_Wilms_Tumor	Stage I Renal Wilms' Tumor|Stage I Nephroblastoma|Stage I Renal Wilm's Tumor|Stage I Renal Wilms Tumor|stage I Wilms' tumor	Cancer that is found in the kidney only and can be completely removed by surgery.
C7841	Stage_II_Wilms_Tumor	Renal_Wilms_Tumor	Stage II Renal Wilms' Tumor|Stage II Nephroblastoma|Stage II Renal Wilms Tumor|stage II Wilms' tumor	Cancer has spread to tissue near the kidney, to blood vessels, or to the renal sinus (a part of the kidney through which blood and fluid enter and exit). The cancer can be completely removed by surgery.
C7842	Stage_III_Wilms_Tumor	Renal_Wilms_Tumor	Stage III Renal Wilms' Tumor|Stage III Nephroblastoma|Stage III Renal Wilms Tumor|stage III Wilms' tumor	Cancer has spread to tissues near the kidney and cannot be completely removed by surgery. The cancer may have spread to blood vessels or organs near the kidney or throughout the abdomen. The cancer may also have spread to lymph nodes near the kidney.
C7843	Stage_IV_Wilms_Tumor	Renal_Wilms_Tumor	Stage IV Renal Wilms' Tumor|Stage IV Nephroblastoma|Stage IV Renal Wilms Tumor|stage IV Wilms' tumor	Cancer has spread to organs further away from the kidney (such as the lungs, liver, bone, and brain).
C7844	Stage_V_Wilms_Tumor	Renal_Wilms_Tumor	Stage V Renal Wilms' Tumor|Stage V Nephroblastoma|Stage V Renal Wilms Tumor|stage V Wilms' tumor	Cancer cells are found in both kidneys.
C7845	Recurrent_Wilms_Tumor	Renal_Wilms_Tumor	Recurrent Renal Wilms' Tumor|Recurrent Kidney Adenosarcoma|Recurrent Nephroblastoma|Recurrent Renal Adenosarcoma|Recurrent Renal Wilms Tumor|Relapsed Kidney Adenosarcoma|Relapsed Nephroblastoma|Relapsed Renal Adenosarcoma|Relapsed Renal Wilms' Tumor
C7846	Intraocular_Retinoblastoma	Retinoblastoma	Intraocular Retinoblastoma	Retinoblastoma restricted to local involvement.
C7847	Stage_0_Chronic_Lymphocytic_Leukemia	Chronic_Lymphocytic_Leukemia	Stage 0 Chronic Lymphocytic Leukemia|CLL Stage 0|Chronic Lymphocytic Leukemia Stage 0|Stage 0 CLL|stage 0 chronic lymphocytic leukemia	Rai staging system. Stage 0 chronic lymphocytic leukemia: absolute lymphocytosis (>15,000 per cubic millimeter) without adenopathy, hepatosplenomegaly, anemia, or thrombocytopenia.
C7848	Extraocular_Retinoblastoma	Retinoblastoma	Extraocular Retinoblastoma	Retinoblastoma that has spread beyond the eye e.g. to brain, soft tissue/bone, bone marrow.
C7849	Recurrent_Retinoblastoma	Retinoblastoma	Recurrent Retinoblastoma|Relapsed Retinoblastoma
C7850	Stage_I_Multiple_Myeloma	Plasma_Cell_Myeloma	Stage I Multiple Myeloma|Multiple Myeloma Stage I|stage I multiple myeloma	Relatively few cancer cells have spread throughout the body. There may be no symptoms of disease.
C7851	Stage_II_Multiple_Myeloma	Plasma_Cell_Myeloma	Stage II Multiple Myeloma|Multiple Myeloma Stage II|stage II multiple myeloma	Cancer in which a moderate number of cancer cells have spread throughout the body.
C7852	Stage_III_Multiple_Myeloma	Plasma_Cell_Myeloma	Stage III Multiple Myeloma|Multiple Myeloma Stage III|stage III multiple myeloma	A relatively large number of cancer cells have spread throughout the body. There may be one or more of the following: 1) a decrease in the number of red blood cells, causing anemia; 2) the amount of calcium in the blood is very high, because the bones are being damaged; 3) more than three bone tumors (plasmacytomas) are found; or 4) high levels of M protein are found in the blood or urine.
C7853	Limited_Stage_Small_Cell_Lung_Carcinoma	Small_Cell_Lung_Carcinoma	Limited Stage Small Cell Lung Carcinoma|Limited Stage Small Cell Carcinoma of Lung|Limited Stage Small Cell Carcinoma of the Lung|limited-stage small cell lung cancer	Cancer found in one lung and in nearby lymph nodes.
C7854	Stage_I_Vulvar_Cancer	Vulvar_Carcinoma	Stage I Vulvar Cancer|AJCC Stage I Vulvar Cancer|FIGO Stage I Carcinoma of Vulva|FIGO Stage I Carcinoma of the Vulva|FIGO Stage I Vulva Carcinoma|FIGO Stage I Vulvar Carcinoma|Stage I Vulva Cancer|Stage I Vulval Cancer|Stage I Vulval Carcinoma|Stage I Vulvar Carcinoma|Vulvar Cancer Stage I|stage I cancer of the vulva	Cancer found in the vulva only or the space between the opening of the rectum and the vagina (perineum). The tumor is 2 centimeters (about 1 inch) or smaller.
C7855	Stage_0_Vaginal_Cancer	High_Grade_Vaginal_Intraepithelial_Neoplasia|Stage_0_Squamous_Cell_Carcinoma|Vaginal_Carcinoma	Stage 0 Vaginal Cancer|AJCC Stage 0 Vaginal Cancer|Carcinoma in situ of Vagina|Carcinoma in situ of the Vagina|FIGO Stage 0 Carcinoma of Vagina|FIGO Stage 0 Carcinoma of the Vagina|FIGO Stage 0 Vagina Carcinoma|FIGO Stage 0 Vaginal Carcinoma|Grade 3 Vaginal Intraepithelial Neoplasia|Grade III Vaginal Intraepithelial Neoplasia|Intraepithelial Neoplasia of Vagina Grade 3|Intraepithelial Neoplasia of the Vagina Grade 3|VAIN 3|VAIN Grade 3|VAIN III|Vagina Carcinoma in situ|Vaginal Cancer Stage 0|Vaginal Carcinoma in situ|Vaginal Intraepithelial Neoplasia Grade 3	Stage 0 includes: (Tis, N0, M0).  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003
C7856	Stage_I_Vaginal_Cancer	Vaginal_Carcinoma	Stage I Vaginal Cancer|AJCC Stage I Vaginal Cancer|FIGO Stage I Carcinoma of Vagina|FIGO Stage I Carcinoma of the Vagina|FIGO Stage I Vagina Carcinoma|FIGO Stage I Vaginal Carcinoma|Vaginal Cancer Stage I	Stage I includes: (T1, N0, M0).  T1: Tumor confined to vagina.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C7857	Stage_II_Vaginal_Cancer	Vaginal_Carcinoma	Stage II Vaginal Cancer|AJCC Stage II Vaginal Cancer|FIGO Stage II Carcinoma of Vagina|FIGO Stage II Carcinoma of the Vagina|FIGO Stage II Vagina Carcinoma|FIGO Stage II Vaginal Carcinoma|Vaginal Cancer Stage II	Stage 2: (T2, N0, M0). T2: Tumor invades paravaginal tissues but not to pelvic wall.  N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th ed.) - 2003
C7858	Stage_III_Vaginal_Cancer	Vaginal_Carcinoma	Stage III Vaginal Cancer|AJCC Stage III Vaginal Cancer|FIGO Stage III Carcinoma of Vagina|FIGO Stage III Carcinoma of the Vagina|FIGO Stage III Vagina Carcinoma|FIGO Stage III Vaginal Carcinoma|Vaginal Cancer Stage III	Stage 3 includes: (T1-3, N1, M0) and (T3, N0, M0). T3: Tumor extends to pelvic wall.  N0: No regional lymph node metastasis.  N1: Pelvic or inguinal lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C7859	Stage_IVA_Vaginal_Cancer	Stage_IV_Vaginal_Cancer	Stage IVA Vaginal Cancer|AJCC Stage IVA Vaginal Cancer|FIGO Stage IVA Carcinoma of Vagina|FIGO Stage IVA Carcinoma of the Vagina|FIGO Stage IVA Vagina Carcinoma|FIGO Stage IVA Vaginal Carcinoma|Vaginal Cancer Stage IVA	Stage IVa includes: T4, Any N, M0. T4: Tumor invades mucosa of the bladder or rectum and/or extends beyond the true pelvis (bullous edema is not sufficient evidence to classify a tumor as T4.). M0: No distant metastasis. (AJCC 6th ed.) - 2003
C7860	Recurrent_Vaginal_Cancer	Recurrent_Female_Reproductive_System_Cancer|Vaginal_Carcinoma	Recurrent Vaginal Cancer|Recurrent Cancer of Vagina|Recurrent Cancer of the Vagina|Recurrent Vagina Cancer|Recurrent Vaginal Carcinoma|Relapsed Cancer of Vagina|Relapsed Cancer of the Vagina|Relapsed Vagina Cancer|Relapsed Vaginal Cancer	The reemergence of vaginal cancer after a period of remission
C7861	Localized_Gastrointestinal_Carcinoid_Tumor	Gastrointestinal_Carcinoid_Tumor	Localized Gastrointestinal Carcinoid Tumor|Localized Carcinoid Neoplasm of Digestive Tract|Localized Carcinoid Neoplasm of the Digestive Tract|Localized Carcinoid Tumor of Digestive Tract|Localized Carcinoid Tumor of the Digestive Tract|Localized Digestive Carcinoid Neoplasm|Localized Digestive Carcinoid Tumor|Localized Digestive Tract Carcinoid Neoplasm|Localized Digestive Tract Carcinoid Tumor|Localized GI Carcinoid Neoplasm|Localized GI Carcinoid Tumor|Localized Gastrointestinal Carcinoid Neoplasm
C7862	Regional_Gastrointestinal_Carcinoid_Tumor	Gastrointestinal_Carcinoid_Tumor	Regional Gastrointestinal Carcinoid Tumor|Regional Carcinoid Neoplasm of Digestive Tract|Regional Carcinoid Neoplasm of the Digestive Tract|Regional Carcinoid Tumor of Digestive Tract|Regional Carcinoid Tumor of the Digestive Tract|Regional Digestive Carcinoid Neoplasm|Regional Digestive Carcinoid Tumor|Regional Digestive Tract Carcinoid Neoplasm|Regional Digestive Tract Carcinoid Tumor|Regional GI Carcinoid Neoplasm|Regional GI Carcinoid Tumor|Regional Gastrointestinal Carcinoid Neoplasm
C7864	Recurrent_Gastrointestinal_Carcinoid_Tumor	Gastrointestinal_Carcinoid_Tumor	Recurrent Gastrointestinal Carcinoid Tumor|Recurrent Carcinoid Neoplasm of Digestive Tract|Recurrent Carcinoid Neoplasm of the Digestive Tract|Recurrent Carcinoid Tumor of Digestive Tract|Recurrent Carcinoid Tumor of the Digestive Tract|Recurrent Digestive Carcinoid Neoplasm|Recurrent Digestive Carcinoid Tumor|Recurrent Digestive Tract Carcinoid Neoplasm|Recurrent Digestive Tract Carcinoid Tumor|Recurrent GI Carcinoid Neoplasm|Recurrent GI Carcinoid Tumor|Recurrent Gastrointestinal Carcinoid Neoplasm|Relapsed Carcinoid Neoplasm of Digestive Tract|Relapsed Carcinoid Neoplasm of the Digestive Tract|Relapsed Carcinoid Tumor of Digestive Tract|Relapsed Carcinoid Tumor of the Digestive Tract|Relapsed Digestive Carcinoid Neoplasm|Relapsed Digestive Carcinoid Tumor|Relapsed Digestive Tract Carcinoid Neoplasm|Relapsed Digestive Tract Carcinoid Tumor|Relapsed GI Carcinoid Neoplasm|Relapsed GI Carcinoid Tumor|Relapsed Gastrointestinal Carcinoid Neoplasm|Relapsed Gastrointestinal Carcinoid Tumor
C7865	Advanced_Malignant_Mesothelioma	Malignant_Mesothelioma	Advanced Malignant Mesothelioma
C7866	Recurrent_Malignant_Mesothelioma	Malignant_Mesothelioma	Recurrent Malignant Mesothelioma|Mesothelioma Malignant Recurrent|Relapsed Malignant Mesothelioma	The reemergence of malignant mesothelioma after a period of remission
C7867	Stage_I_Penile_Cancer	Penile_Carcinoma	Stage I Penile Cancer|Penile Cancer Stage I|Penile Carcinoma Stage I|Stage I Carcinoma of Penis|Stage I Carcinoma of the Penis|Stage I Penile Carcinoma|Stage I Penis Cancer|Stage I Penis Carcinoma	Stage I includes: (T1, N0, M0).  T1: Tumor invades subepithelial connective tissue.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C7868	Stage_II_Penile_Cancer	Penile_Carcinoma	Stage II Penile Cancer|Penile Cancer Stage II|Penile Carcinoma Stage II|Stage II Carcinoma of Penis|Stage II Carcinoma of the Penis|Stage II Penile Carcinoma|Stage II Penis Cancer|Stage II Penis Carcinoma	Stage II includes: (T1, N1, M0); (T2, N0, M0); (T2, N1, M0).  T1: Tumor invades subepithelial connective tissue.  N0: No regional lymph node metastasis.  N1: Metastasis in a single superficial, inguinal lymph node.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C7869	Stage_III_Penile_Cancer	Penile_Carcinoma	Stage III Penile Cancer|Penile Cancer Stage III|Penile Carcinoma Stage III|Stage III Carcinoma of Penis|Stage III Carcinoma of the Penis|Stage III Penile Carcinoma|Stage III Penis Cancer|Stage III Penis Carcinoma	Stage III includes: (T1, N2, M0); (T2, N2, M0); (T3, N0, M0); (T3, N1, M0); (T3, N2, M0).  T1: Tumor invades subepithelial connective tissue.  T2: Tumor invades corpus spongiosum or cavernosum.  T3: Tumor invades urethra or prostate.  N0: No regional lymph node metastasis.  N1: Metastasis in single superficial, inguinal lymph node. N2: Metastasis in multiple or bilateral superficial inguinal lymph nodes.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C7870	Recurrent_Penile_Cancer	Penile_Carcinoma|Recurrent_Male_Reproductive_System_Cancer	Recurrent Penile Cancer|Recurrent Carcinoma of Penis|Recurrent Carcinoma of the Penis|Recurrent Penile Carcinoma|Recurrent Penis Cancer|Recurrent Penis Carcinoma|Relapsed Carcinoma of Penis|Relapsed Carcinoma of the Penis|Relapsed Penile Carcinoma	A carcinoma of the penis that reappears after a period of remission.
C7871	Adult_Diffuse_Mixed_Cell_Lymphoma	Diffuse_Mixed_Cell_Lymphoma	Adult Diffuse Mixed Cell Lymphoma
C7872	Adult_Diffuse_Large_Cell_Lymphoma	Diffuse_Malignant_Lymphoma|Malignant_Lymphoma_Large_Cell_Type	Adult Diffuse Large Cell Lymphoma|Adult Diffuse Histiocytic Lymphoma|Diffuse Histiocytic Adult Lymphoma|Diffuse Large Cell Adult Lymphoma
C7873	Adult_Immunoblastic_Lymphoma	Adult_Diffuse_Large_B-Cell_Lymphoma|Immunoblastic_Lymphoma	Adult Immunoblastic Lymphoma|Adult Immunoblastic Large Cell Lymphoma
C7874	Stage_I_Chronic_Lymphocytic_Leukemia	Chronic_Lymphocytic_Leukemia	Stage I Chronic Lymphocytic Leukemia|CLL Stage I|Chronic Lymphocytic Leukemia Stage I|Stage I CLL|stage I chronic lymphocytic leukemia	Stage I chronic lymphocytic leukemia: absolute lymphocytosis with lymphadenopathy without hepatosplenomegaly, anemia, or thrombocytopenia.
C7875	Stage_II_Chronic_Lymphocytic_Leukemia	Chronic_Lymphocytic_Leukemia	Stage II Chronic Lymphocytic Leukemia|CLL Stage II|Chronic Lymphocytic Leukemia Stage II|Stage II CLL|stage II chronic lymphocytic leukemia	Stage II chronic lymphocytic leukemia: absolute lymphocytosis with either hepatomegaly or splenomegaly, with or without lymphadenopathy.
C7876	Stage_III_Chronic_Lymphocytic_Leukemia	Chronic_Lymphocytic_Leukemia	Stage III Chronic Lymphocytic Leukemia|CLL Stage III|Chronic Lymphocytic Leukemia Stage III|Stage III CLL|stage III chronic lymphocytic leukemia	Stage III chronic lymphocytic leukemia: absolute lymphocytosis and anemia (hemoglobin <11 g/dL) with or without lymphadenopathy, hepatomegaly, or splenomegaly.
C7877	Localized_Resectable_Adult_Liver_Cancer	Adult_Liver_Carcinoma	Localized Resectable Adult Liver Cancer|Localized Resectable Adult Liver Carcinoma|Localized Resectable Adult Primary Cancer of Liver|Localized Resectable Adult Primary Cancer of the Liver|Localized Resectable Adult Primary Liver Cancer
C7878	Localized_Unresectable_Adult_Liver_Cancer	Adult_Liver_Carcinoma	Localized Unresectable Adult Liver Cancer|Localized Unresectable Adult Liver Carcinoma|Localized Unresectable Adult Primary Cancer of Liver|Localized Unresectable Adult Primary Cancer of the Liver|Localized Unresectable Adult Primary Liver Cancer
C7880	Recurrent_Adult_Liver_Cancer	Adult_Liver_Carcinoma|Recurrent_Liver_Cancer	Recurrent Adult Liver Cancer|Recurrent Adult Primary Cancer of Liver|Recurrent Adult Primary Cancer of the Liver|Recurrent Adult Primary Liver Cancer|Relapsed Adult Liver Cancer|Relapsed Adult Primary Cancer of Liver|Relapsed Adult Primary Cancer of the Liver|Relapsed Adult Primary Liver Cancer
C7881	Recurrent_Osteosarcoma	Osteosarcoma	Recurrent Osteosarcoma|Osteosarcoma, Recurrent|Recurrent Osteogenic Sarcoma|Relapsed Osteogenic Sarcoma|Relapsed Osteosarcoma	Osteosarcoma reappearing after a remission
C7882	Recurrent_Adult_Acute_Myeloid_Leukemia	Adult_Acute_Myeloid_Leukemia|Relapsed_Hematologic_Malignancy	Recurrent Adult Acute Myeloid Leukemia|Recurrent Adult AML|Recurrent Adult Acute Myelogenous Leukemia|Recurrent Adult Acute Non-Lymphocytic Leukemia|Relapsed Adult AML|Relapsed Adult Acute Myelogenous Leukemia|Relapsed Adult Acute Myeloid Leukemia
C7883	Recurrent_Adult_Acute_Lymphoblastic_Leukemia	Adult_Acute_Lymphoblastic_Leukemia|Relapsed_Hematologic_Malignancy	Recurrent Adult Acute Lymphoblastic Leukemia|Recurrent Adult ALL|Recurrent Adult Acute Lymphocytic Leukemia|Recurrent Adult Acute Lymphogenous Leukemia|Recurrent Adult Acute Lymphoid Leukemia|Relapsed Adult ALL|Relapsed Adult Acute Lymphoblastic Leukemia|Relapsed Adult Acute Lymphocytic Leukemia|Relapsed Adult Acute Lymphogenous Leukemia|Relapsed Adult Acute Lymphoid Leukemia
C7884	Recurrent_Adult_Brain_Neoplasm	Adult_Brain_Neoplasm	Recurrent Adult Brain Neoplasm|Recurrent Adult Brain Tumor|Recurrent Neoplasm of Adult Brain|Recurrent Neoplasm of the Adult Brain|Recurrent Tumor of Adult Brain|Recurrent Tumor of the Adult Brain|Relapsed Adult Brain Neoplasm|Relapsed Adult Brain Tumor|Relapsed Neoplasm of Adult Brain|Relapsed Neoplasm of the Adult Brain|Relapsed Tumor of Adult Brain|Relapsed Tumor of the Adult Brain
C7885	Refractory_Chronic_Myelogenous_Leukemia	Chronic_Myelogenous_Leukemia|Refractory_Hematologic_Malignancy	Refractory Chronic Myelogenous Leukemia|Refractory CGL|Refractory CML|Refractory Chronic Granulocytic Leukemia|Refractory Chronic Myelocytic Leukemia|Refractory Chronic Myeloid Leukemia
C7886	Refractory_Chronic_Lymphocytic_Leukemia	Chronic_Lymphocytic_Leukemia|Refractory_Hematologic_Malignancy	Refractory Chronic Lymphocytic Leukemia|Chronic Lymphocytic Leukemia Refractory|Refractory CLL|Refractory Chronic Lymphogenous Leukemia|Refractory Chronic Lymphoid Leukemia	Chronic lymphocytic lymphoma that is resistant to treatment
C7887	Recurrent_Gestational_Trophoblastic_Tumor	Gestational_Trophoblastic_Tumor	Recurrent Gestational Trophoblastic Tumor|Recurrent GTT|Recurrent Gestational Trophoblastic Disease|Recurrent Gestational Trophoblastic Neoplasm|Relapsed GTT|Relapsed Gestational Trophoblastic Disease|Relapsed Gestational Trophoblastic Neoplasm|Relapsed Gestational Trophoblastic Tumor
C7888	Small_Intestinal_Adenocarcinoma	Adenocarcinoma|Small_Intestinal_Carcinoma	Small Intestinal Adenocarcinoma|Adenocarcinoma of Small Bowel|Adenocarcinoma of Small Intestine|Adenocarcinoma of the Small Bowel|Adenocarcinoma of the Small Intestine|Small Bowel Adenocarcinoma
C7889	Duodenal_Adenocarcinoma	Small_Intestinal_Adenocarcinoma	Duodenal Adenocarcinoma|Adenocarcinoma of Duodenum|Adenocarcinoma of the Duodenum
C7890	Unresectable_Gallbladder_Cancer	Gallbladder_Carcinoma	Unresectable Gallbladder Cancer|Gallbladder Cancer Unresectable|Gallbladder Carcinoma Unresectable|Unresectable Cancer of Gallbladder|Unresectable Cancer of the Gallbladder|Unresectable Gallbladder Carcinoma|unresectable gallbladder cancer	Cancer that has spread to the tissues around the gallbladder (such as the liver, stomach, pancreas, intestine, or lymph nodes in the area) and cannot be surgically removed.
C7891	Localized_Extrahepatic_Bile_Duct_Carcinoma	Extrahepatic_Bile_Duct_Carcinoma	Localized Extrahepatic Bile Duct Carcinoma|Localized Cancer of Extrahepatic Bile Duct|Localized Cancer of the Extrahepatic Bile Duct|Localized Extrahepatic Bile Duct Cancer
C7892	Unresectable_Extrahepatic_Bile_Duct_Carcinoma	Extrahepatic_Bile_Duct_Carcinoma	Unresectable Extrahepatic Bile Duct Carcinoma|Non-Resectable Extrahepatic Bile Duct Carcinoma|Unresectable Cancer of Extrahepatic Bile Duct|Unresectable Cancer of the Extrahepatic Bile Duct|Unresectable Extrahepatic Bile Duct Cancer	Bile duct cancer not amenable to surgical removal
C7893	Recurrent_Extrahepatic_Bile_Duct_Carcinoma	Extrahepatic_Bile_Duct_Carcinoma	Recurrent Extrahepatic Bile Duct Carcinoma|Recurrent Cancer of Extrahepatic Bile Duct|Recurrent Cancer of the Extrahepatic Bile Duct|Recurrent Extrahepatic Bile Duct Cancer|Relapsed Cancer of Extrahepatic Bile Duct|Relapsed Cancer of the Extrahepatic Bile Duct
C7894	Recurrent_Small_Intestinal_Cancer	Small_Intestinal_Carcinoma	Recurrent Small Intestinal Cancer|Recurrent Cancer of Small Intestine|Recurrent Cancer of the Small Intestine|Recurrent Carcinoma of Small Bowel|Recurrent Carcinoma of Small Intestine|Recurrent Carcinoma of the Small Bowel|Recurrent Carcinoma of the Small Intestine|Recurrent Small Bowel Carcinoma|Recurrent Small Intestine Carcinoma|Relapsed Cancer of Small Intestine|Relapsed Cancer of the Small Intestine|Relapsed Carcinoma of Small Bowel|Relapsed Carcinoma of Small Intestine|Relapsed Carcinoma of the Small Bowel|Relapsed Carcinoma of the Small Intestine|Relapsed Small Bowel Carcinoma|Relapsed Small Intestine Cancer|Relapsed Small Intestine Carcinoma|Small Intestine Carcinoma, Recurrent	The reemergence of small intestine carcinoma after a period of remission.
C7895	Stage_0_Bladder_Cancer	Bladder_Carcinoma	Stage 0 Bladder Cancer|Bladder Cancer Stage 0|Stage 0 Bladder Carcinoma|Stage 0 Carcinoma of Bladder|Stage 0 Carcinoma of Urinary Bladder|Stage 0 Carcinoma of the Bladder|Stage 0 Carcinoma of the Urinary Bladder|Stage 0 Urinary Bladder Carcinoma	Stage 0 includes Ta, Tis, N0, M0 Ta: Non-invasive papillary carcinoma.  Tis: Carcinoma in situ: "flat tumor".  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th Ed.) - 2003
C7896	Stage_I_Bladder_Cancer	Bladder_Carcinoma	Stage I Bladder Cancer|Bladder Cancer Stage I|Jewett-Marshall Stage A Bladder Cancer|Jewett-Marshall Stage A Bladder Carcinoma|Jewett-Marshall Stage A Urinary Bladder Cancer|Jewett-Marshall Stage A Urinary Bladder Carcinoma|Stage I Bladder Carcinoma|Stage I Carcinoma of Bladder|Stage I Carcinoma of Urinary Bladder|Stage I Carcinoma of the Bladder|Stage I Carcinoma of the Urinary Bladder|Stage I Urinary Bladder Carcinoma|stage I bladder cancer	Cancer that has spread into the inner lining of the bladder but not to the muscular wall of the bladder.
C7897	Stage_II_Bladder_Cancer	Bladder_Carcinoma	Stage II Bladder Cancer|Cancer of Bladder Stage II|Cancer of the Bladder Stage II|Jewett-Marshall Stage B Bladder Cancer|Jewett-Marshall Stage B Bladder Carcinoma|Jewett-Marshall Stage B Urinary Bladder Cancer|Jewett-Marshall Stage B Urinary Bladder Carcinoma|Stage II Bladder Carcinoma|Stage II Carcinoma of Bladder|Stage II Carcinoma of Urinary Bladder|Stage II Carcinoma of the Bladder|Stage II Carcinoma of the Urinary Bladder|Stage II Urinary Bladder Carcinoma|stage II bladder cancer	Cancer that has spread to the muscular wall of the bladder.
C7898	Stage_III_Bladder_Cancer	Bladder_Carcinoma	Stage III Bladder Cancer|Cancer of Bladder Stage III|Cancer of the Bladder Stage III|Jewett-Marshall Stage C Bladder Cancer|Jewett-Marshall Stage C Urinary Bladder Cancer|Jewett-Marshall Stage C Urinary Bladder Carcinoma|Stage III Bladder Carcinoma|Stage III Carcinoma of Bladder|Stage III Carcinoma of Urinary Bladder|Stage III Carcinoma of the Bladder|Stage III Carcinoma of the Urinary Bladder|Stage III Urinary Bladder Carcinoma|stage III bladder cancer	Cancer cells have spread throughout the muscular wall of the bladder, to the layer of tissue surrounding the bladder, and/or to the nearby reproductive organs.
C7899	Recurrent_Bladder_Cancer	Bladder_Carcinoma|Recurrent_Urinary_Tract_Cancer	Recurrent Bladder Cancer|Bladder Cancer, Recurrent|Bladder Carcinoma Recurrent|Recurrent Bladder Carcinoma|Recurrent Cancer of Bladder|Recurrent Cancer of Urinary Bladder|Recurrent Cancer of the Bladder|Recurrent Cancer of the Urinary Bladder|Recurrent Urinary Bladder Cancer|Relapsed Bladder Cancer|Relapsed Cancer of Bladder|Relapsed Cancer of Urinary Bladder|Relapsed Cancer of the Bladder|Relapsed Cancer of the Urinary Bladder|Relapsed Urinary Bladder Cancer	The reemergence of bladder cancer after a period of remission
C7900	Stage_IV_Bladder_Cancer	Bladder_Carcinoma	Stage IV Bladder Cancer|Cancer of Bladder Stage IV|Cancer of the Bladder Stage IV|Jewett-Marshall Stage D Bladder Cancer|Jewett-Marshall Stage D Bladder Carcinoma|Jewett-Marshall Stage D Urinary Bladder Cancer|Jewett-Marshall Stage D Urinary Bladder Carcinoma|Stage IV Bladder Carcinoma|Stage IV Carcinoma of Bladder|Stage IV Carcinoma of Urinary Bladder|Stage IV Carcinoma of the Bladder|Stage IV Carcinoma of the Urinary Bladder|Stage IV Urinary Bladder Carcinoma|stage IV bladder cancer	Cancer cells have spread to the wall of the abdomen or pelvis or to nearby lymph nodes, or it has spread to lymph nodes and other parts of the body far from the bladder.
C7901	Stage_I_Testicular_Cancer	Malignant_Testicular_Germ_Cell_Tumor	Stage I Testicular Cancer|Stage I Cancer of Testis|Stage I Cancer of the Testis|Stage I Testicular Germ Cell Tumor|stage I testicular cancer	Cancer that is found in the testicle only or has spread into the scrotum.
C7902	Recurrent_Prostate_Cancer	Prostate_Carcinoma|Recurrent_Male_Reproductive_System_Cancer	Recurrent Prostate Cancer|Recurrent Cancer of Prostate|Recurrent Cancer of the Prostate|Recurrent Prostate Carcinoma	Prostate cancer reemerging after a period of remission.
C7903	Recurrent_Skin_Cancer	Recurrent_Carcinoma|Skin_Carcinoma	Recurrent Skin Cancer|Recurrent Cancer of Skin|Recurrent Cancer of the Skin|Recurrent Carcinoma of Skin|Recurrent Carcinoma of the Skin|Recurrent Cutaneous Carcinoma|Recurrent Skin Carcinoma
C7904	Invasive_Malignant_Thymoma	Invasive_Thymoma|Malignant_Thymoma	Invasive Malignant Thymoma|Malignant Thymoma, Invasive|Thymoma Malignant Invasive	A malignant thymoma that extends beyond the capsule and infiltrates the surrounding tissues.  --2003
C7905	Recurrent_Malignant_Thymoma	Malignant_Thymoma	Recurrent Malignant Thymoma|Malignant Thymoma, Recurrent|Thymoma Malignant Recurrent	Reemergence of malignant thymoma after a period of remission.
C7906	Anaplastic_Giant_Cell_Thyroid_Carcinoma	Anaplastic_Thyroid_Carcinoma	Thyroid Gland Undifferentiated Carcinoma, Osteoclastic Variant|Anaplastic Giant Cell Carcinoma of Thyroid|Anaplastic Giant Cell Carcinoma of Thyroid Gland|Anaplastic Giant Cell Carcinoma of the Thyroid|Anaplastic Giant Cell Carcinoma of the Thyroid Gland|Anaplastic Giant Cell Thyroid Carcinoma|Anaplastic Giant Cell Thyroid Gland Carcinoma|Thyroid Gland Undifferentiated Giant Cell Carcinoma|Undifferentiated Giant Cell Carcinoma of Thyroid|Undifferentiated Giant Cell Carcinoma of Thyroid Gland|Undifferentiated Giant Cell Carcinoma of the Thyroid|Undifferentiated Giant Cell Carcinoma of the Thyroid Gland|Undifferentiated Giant Cell Thyroid Carcinoma|Undifferentiated Giant Cell Thyroid Gland Carcinoma	A morphologic variant of undifferentiated (anaplastic) carcinoma of the thyroid gland, characterized by the presence of large numbers of non-neoplastic, osteoclast-like giant cells. (NCI05)
C7907	Anaplastic_Small_Cell_Thyroid_Carcinoma	Neoplasm_by_Obsolete_Classification	Thyroid Gland Undifferentiated Small Cell Carcinoma|Anaplastic Small Cell Carcinoma of Thyroid|Anaplastic Small Cell Carcinoma of Thyroid Gland|Anaplastic Small Cell Carcinoma of the Thyroid|Anaplastic Small Cell Carcinoma of the Thyroid Gland|Anaplastic Small Cell Thyroid Carcinoma|Anaplastic Small Cell Thyroid Gland Carcinoma|Undifferentiated Small Cell Carcinoma of Thyroid|Undifferentiated Small Cell Carcinoma of Thyroid Gland|Undifferentiated Small Cell Carcinoma of the Thyroid|Undifferentiated Small Cell Carcinoma of the Thyroid Gland|Undifferentiated Small Cell Thyroid Carcinoma|Undifferentiated Small Cell Thyroid Gland Carcinoma
C7908	Recurrent_Thyroid_Carcinoma	Recurrent_Head_and_Neck_Cancer|Thyroid_Carcinoma	Recurrent Thyroid Gland Carcinoma|Recurrent Cancer of Thyroid|Recurrent Cancer of Thyroid Gland|Recurrent Cancer of the Thyroid|Recurrent Cancer of the Thyroid Gland|Recurrent Thyroid Cancer|Recurrent Thyroid Carcinoma|Relapsed Cancer of Thyroid|Relapsed Cancer of Thyroid Gland|Relapsed Cancer of the Thyroid|Relapsed Cancer of the Thyroid Gland|Relapsed Thyroid Cancer|Relapsed Thyroid Gland Cancer	The reemergence of a thyroid gland carcinoma after a period of remission. (NCI05)
C7909	Pituitary_Corticotropin_Secreting_Tumor	Anterior_Pituitary_Gland_Neoplasm	ACTH Producing Pituitary Gland Neoplasm|ACTH-Producing Pituitary Neoplasm|ACTH-Producing Pituitary Tumor|ACTH-Secreting Tumor of Pituitary|ACTH-Secreting Tumor of the Pituitary|Adrenocorticotropin Producing Pituitary Gland Tumor|Adrenocorticotropin Secreting Neoplasm of Pituitary|Adrenocorticotropin Secreting Neoplasm of the Pituitary|Adrenocorticotropin Secreting Pituitary Gland Tumor|Adrenocorticotropin Secreting Tumor of Pituitary|Adrenocorticotropin Secreting Tumor of the Pituitary|Corticotropin Secreting Pituitary Gland Neoplasm|Pituitary Corticotropin Secreting Neoplasm|Pituitary Corticotropin Secreting Tumor	An adenoma or carcinoma of the pituitary gland that produces corticotropin. (NCI05)
C7910	Prolactin_Producing_Pituitary_Gland_Neoplasm	Anterior_Pituitary_Gland_Neoplasm	Prolactin Producing Pituitary Gland Neoplasm|PRL Producing Pituitary Gland Neoplasm|Prolactin Producing Neoplasm of Pituitary|Prolactin Producing Neoplasm of Pituitary Gland|Prolactin Producing Neoplasm of the Pituitary|Prolactin Producing Neoplasm of the Pituitary Gland|Prolactin Producing Pituitary Gland Tumor|Prolactin Producing Pituitary Neoplasm|Prolactin Producing Pituitary Tumor|Prolactin Producing Pituitary Tumour|Prolactin Producing Tumor of Pituitary|Prolactin Producing Tumor of Pituitary Gland|Prolactin Producing Tumor of the Pituitary|Prolactin Producing Tumor of the Pituitary Gland|Prolactin Secreting Neoplasm of Pituitary|Prolactin Secreting Neoplasm of Pituitary Gland|Prolactin Secreting Neoplasm of the Pituitary|Prolactin Secreting Neoplasm of the Pituitary Gland|Prolactin Secreting Pituitary Gland Neoplasm|Prolactin Secreting Pituitary Gland Tumor|Prolactin Secreting Pituitary Neoplasm|Prolactin Secreting Pituitary Tumor|Prolactin Secreting Tumor of Pituitary|Prolactin Secreting Tumor of Pituitary Gland|Prolactin Secreting Tumor of the Pituitary|Prolactin Secreting Tumor of the Pituitary Gland	An adenoma or carcinoma of the anterior lobe of the pituitary gland that produces prolactin. (NCI05)
C7911	Growth_Hormone_Secreting_Pituitary_Neoplasm	Anterior_Pituitary_Gland_Neoplasm	Growth Hormone Producing Pituitary Gland Neoplasm|Growth Hormone Producing Neoplasm of Pituitary|Growth Hormone Producing Neoplasm of Pituitary Gland|Growth Hormone Producing Neoplasm of the Pituitary|Growth Hormone Producing Neoplasm of the Pituitary Gland|Growth Hormone Producing Pituitary Gland Tumor|Growth Hormone Producing Pituitary Neoplasm|Growth Hormone Producing Pituitary Tumor|Growth Hormone Producing Tumor|Growth Hormone Producing Tumor of Pituitary|Growth Hormone Producing Tumor of Pituitary Gland|Growth Hormone Producing Tumor of the Pituitary|Growth Hormone Producing Tumor of the Pituitary Gland|Growth Hormone Secreting Neoplasm of Pituitary|Growth Hormone Secreting Neoplasm of Pituitary Gland|Growth Hormone Secreting Neoplasm of the Pituitary|Growth Hormone Secreting Neoplasm of the Pituitary Gland|Growth Hormone Secreting Pituitary Gland Neoplasm|Growth Hormone Secreting Pituitary Gland Tumor|Growth Hormone Secreting Pituitary Neoplasm|Growth Hormone Secreting Pituitary Tumor|Growth Hormone Secreting Tumor of Pituitary|Growth Hormone Secreting Tumor of Pituitary Gland|Growth Hormone Secreting Tumor of the Pituitary|Growth Hormone Secreting Tumor of the Pituitary Gland|Pituitary Gland Somatotropinoma|Pituitary Somatotropinoma|Somatotropinoma|Somatotropinoma of Pituitary|Somatotropinoma of Pituitary Gland|Somatotropinoma of the Pituitary|Somatotropinoma of the Pituitary Gland	An adenoma or carcinoma of the anterior lobe of the pituitary gland that produces growth hormone. (NCI05)
C7912	Recurrent_Pituitary_Gland_Neoplasm	Anterior_Pituitary_Gland_Neoplasm	Recurrent Anterior Pituitary Gland Neoplasm|Recurrent Anterior Pituitary Gland Tumor|Recurrent Anterior Pituitary Neoplasm|Recurrent Anterior Pituitary Tumor|Recurrent Neoplasm of Anterior Pituitary|Recurrent Neoplasm of Anterior Pituitary Gland|Recurrent Neoplasm of the Anterior Pituitary|Recurrent Neoplasm of the Anterior Pituitary Gland|Recurrent Tumor of Anterior Pituitary|Recurrent Tumor of Anterior Pituitary Gland|Recurrent Tumor of the Anterior Pituitary|Recurrent Tumor of the Anterior Pituitary Gland|Relapsed Anterior Pituitary Gland Neoplasm|Relapsed Anterior Pituitary Gland Tumor|Relapsed Anterior Pituitary Neoplasm|Relapsed Anterior Pituitary Tumor|Relapsed Neoplasm of Anterior Pituitary|Relapsed Neoplasm of Anterior Pituitary Gland|Relapsed Neoplasm of the Anterior Pituitary|Relapsed Neoplasm of the Anterior Pituitary Gland|Relapsed Tumor of Anterior Pituitary Gland|Relapsed Tumor of the Anterior Pituitary Gland	The re-emergence of a pituitary gland adenoma or carcinoma after a period of remission. (NCI05)
C7913	Extraocular_Extension_Melanoma	Ocular_Melanoma	Extraocular Extension Melanoma|Extraocular Extension of Melanoma
C7914	Recurrent_Uveal_Melanoma	Uveal_Melanoma	Recurrent Uveal Melanoma|Recurrent Melanoma of Uvea|Recurrent Melanoma of the Uvea
C7915	Thyroid_Stimulating_Hormone_Producing_Pituitary_Gland_Neoplasm	Anterior_Pituitary_Gland_Neoplasm	TSH Producing Pituitary Gland Neoplasm|TSH Producing Neoplasm of Pituitary|TSH Producing Neoplasm of Pituitary Gland|TSH Producing Neoplasm of the Pituitary|TSH Producing Neoplasm of the Pituitary Gland|TSH Producing Pituitary Gland Tumor|TSH Producing Pituitary Neoplasm|TSH Producing Pituitary Tumor|TSH Producing Tumor of Pituitary|TSH Producing Tumor of Pituitary Gland|TSH Producing Tumor of the Pituitary|TSH Producing Tumor of the Pituitary Gland|TSH Secreting Neoplasm of Pituitary|TSH Secreting Neoplasm of Pituitary Gland|TSH Secreting Neoplasm of the Pituitary|TSH Secreting Neoplasm of the Pituitary Gland|TSH Secreting Pituitary Gland Neoplasm|TSH Secreting Pituitary Gland Tumor|TSH Secreting Pituitary Neoplasm|TSH Secreting Pituitary Tumor|TSH Secreting Tumor of Pituitary|TSH Secreting Tumor of Pituitary Gland|TSH Secreting Tumor of the Pituitary|TSH Secreting Tumor of the Pituitary Gland|Thyroid Stimulating Hormone Producing Neoplasm of Pituitary|Thyroid Stimulating Hormone Producing Neoplasm of Pituitary Gland|Thyroid Stimulating Hormone Producing Neoplasm of the Pituitary|Thyroid Stimulating Hormone Producing Neoplasm of the Pituitary Gland|Thyroid Stimulating Hormone Producing Pituitary Gland Neoplasm|Thyroid Stimulating Hormone Producing Pituitary Gland Tumor|Thyroid Stimulating Hormone Producing Pituitary Neoplasm|Thyroid Stimulating Hormone Producing Pituitary Tumor|Thyroid Stimulating Hormone Producing Tumor of Pituitary|Thyroid Stimulating Hormone Producing Tumor of Pituitary Gland|Thyroid Stimulating Hormone Producing Tumor of the Pituitary|Thyroid Stimulating Hormone Producing Tumor of the Pituitary Gland|Thyroid Stimulating Hormone Producing Tumour|Thyroid Stimulating Hormone Secreting Neoplasm of Pituitary|Thyroid Stimulating Hormone Secreting Neoplasm of Pituitary Gland|Thyroid Stimulating Hormone Secreting Neoplasm of the Pituitary|Thyroid Stimulating Hormone Secreting Neoplasm of the Pituitary Gland|Thyroid Stimulating Hormone Secreting Pituitary Gland Neoplasm|Thyroid Stimulating Hormone Secreting Pituitary Gland Tumor|Thyroid Stimulating Hormone Secreting Pituitary Neoplasm|Thyroid Stimulating Hormone Secreting Pituitary Tumor|Thyroid Stimulating Hormone Secreting Tumor of Pituitary|Thyroid Stimulating Hormone Secreting Tumor of Pituitary Gland|Thyroid Stimulating Hormone Secreting Tumor of the Pituitary|Thyroid Stimulating Hormone Secreting Tumor of the Pituitary Gland|Thyrotropin Producing Pituitary Gland Neoplasm	An adenoma or carcinoma of the anterior lobe of the pituitary gland that produces thyrotropin. (NCI05)
C7916	Stage_I_Melanoma_of_the_Skin	Cutaneous_Melanoma	Stage I Skin Melanoma|Malignant Melanoma (of Skin), Stage I|Stage I Cutaneous Melanoma|Stage I Malignant Cutaneous Melanoma|Stage I Malignant Melanoma of Skin|Stage I Malignant Melanoma of the Skin|Stage I Malignant Skin Melanoma|Stage I Melanoma of Skin|Stage I Melanoma of the Skin|stage I melanoma	Cancer found in the outer layer of the skin (epidermis), the upper part of the inner layer of skin (dermis), or both but not in nearby lymph nodes. The tumor is no thicker than 1.5 millimeters (about 1/16 of an inch).
C7917	Stage_II_Melanoma_of_the_Skin	Cutaneous_Melanoma	Stage II Skin Melanoma|Malignant Melanoma (of Skin), Stage II|Stage II Cutaneous Melanoma|Stage II Malignant Cutaneous Melanoma|Stage II Malignant Melanoma of Skin|Stage II Malignant Melanoma of the Skin|Stage II Malignant Skin Melanoma|Stage II Melanoma|Stage II Melanoma of Skin|Stage II Melanoma of the Skin|stage II melanoma	Stage II includes: IIA (T2b, N0, M0); (T3a, N0, M0); IIB (T3b, N0, M0); (T4a, N0, M0); IIC (T4b, N0, M0).  T2b: Melanoma 1.01 - 2.0mm in thickness, with ulceration.  T3a: Melanoma 2.01 - 4.0mm in thickness, no ulceration.  T3b: Melanoma 2.01 - 4.0mm in thickness, with ulceration.  T4a: Melanoma is greater than 4.0 mm in thickness, no ulceration.  T4b: Melanoma is greater than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastasis.  M0: No distant metastasis. - 2003
C7918	Stage_III_Melanoma_of_the_Skin	Cutaneous_Melanoma	Stage III Skin Melanoma|Malignant Melanoma (of Skin), Stage III|Stage III Cutaneous Melanoma|Stage III Malignant Cutaneous Melanoma|Stage III Malignant Melanoma of Skin|Stage III Malignant Melanoma of the Skin|Stage III Malignant Skin Melanoma|Stage III Melanoma of Skin|Stage III Melanoma of the Skin|stage III melanoma	Stage III includes: (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0).  N1: Metastasis in one lymph node.  N2: Metastasis in two to three regional lymph nodes or intralymphatic regional metastasis without nodal metastases.  N3: Metastasis in four or more regional nodes, or matted metastatic nodes, or in-transit metastasis or satellite(s) with metastasis in regional node(s). - 2003
C7919	No_Measurable_or_Evaluable_Disease	Clinical_Course_of_Disease	No Measurable or Evaluable Disease
C7920	Stage_II_Nasopharyngeal_Carcinoma	Nasopharyngeal_Carcinoma	Stage II Nasopharyngeal Carcinoma|Nasopharyngeal Cancer, Stage II|Stage II Carcinoma of Nasopharynx|Stage II Carcinoma of the Nasopharynx|Stage II Nasopharyngeal Cancer|Stage II Nasopharynx Carcinoma|stage II nasopharynx cancer	Stage II includes: IIA (T2a, N0, M0); IIB (T1, N1, M0), (T2, N1, M0), (T2a, N1, M0); (T2b, N0, M0); (T2b, N0, M0); (T2b, N1, M0).  T2: Tumor extends to soft tissues.  T2a: Tumor extends to the oropharynx and/or nasal cavity without parapharyngeal extension.  T2b: Any tumor with parapharyngeal extension.  N1: Unilateral metastasis in lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003
C7922	New_York_Heart_Association_Class_III_IV	Cardiovascular_System_Finding	New York Heart Association Class III/IV	The two most severe classes of cardiac dysfunction according to a classification system developed by the New York Heart Association to grade cardiovascular function and disability. These classes are defined as follows: Class III - patients with cardiac disease producing marked limitation of activity: comfortable at rest. Less than ordinary physical activity causes symptoms. Class IV - patients with cardiac disease resulting in inability to carry on any physical activity without discomfort. Symptoms may be present even at rest. --2004
C7923	Active_Peptic_Ulcer_Disease_GI_Bleeding	Peptic_Ulcer	Active Peptic Ulcer
C7924	Adult_Extraskeletal_Chondrosarcoma	Extraskeletal_Chondrosarcoma	Adult Extraskeletal Chondrosarcoma|Adult Extraosseous Chondrosarcoma
C7925	Adult_Extraskeletal_Osteosarcoma	Adult_Soft_Tissue_Sarcoma|Extraskeletal_Osteosarcoma	Adult Extraskeletal Osteosarcoma|Adult Extraosseous Osteosarcoma
C7926	Recurrent_Salivary_Gland_Carcinoma	Recurrent_Carcinoma|Recurrent_Malignant_Neoplasm_of_Salivary_Gland|Salivary_Gland_Carcinoma	Recurrent Salivary Gland Cancer|Recurrent Cancer of Salivary Gland|Recurrent Cancer of the Salivary Gland|Recurrent Carcinoma of Salivary Gland|Recurrent Carcinoma of the Salivary Gland|Recurrent Salivary Gland Carcinoma|Relapsed Cancer of Salivary Gland|Relapsed Cancer of the Salivary Gland|Relapsed Carcinoma of Salivary Gland|Relapsed Carcinoma of the Salivary Gland|Relapsed Salivary Gland Cancer|Relapsed Salivary Gland Carcinoma|Salivary Gland Cancer, Recurrent	The reemergence of salivary gland cancer after a period of remission
C7927	Liver_and_Intrahepatic_Biliary_Tract_Carcinoma	Carcinoma|Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Primary_Malignant_Neoplasm_of_Liver	Liver and Intrahepatic Biliary Tract Carcinoma|Cancer of Liver|Cancer of Liver and Intrahepatic Biliary Tract|Cancer of the Liver|Cancer of the Liver and Intrahepatic Biliary Tract|Hepatic Cancer|Liver Cancer|Liver and Intrahepatic Bile Duct Cancer|Liver and Intrahepatic Bile Duct Carcinoma|Liver and Intrahepatic Biliary Tract Cancer|Primary Liver Carcinoma|liver cancer	A carcinoma arising from the liver or intrahepatic bile duct.  The main subtypes are hepatocellular carcinoma (hepatoma) and cholangiocarcinoma. -- 2004
C7928	Childhood_Germ_Cell_Neoplasm	Childhood_Neoplasm|Germ_Cell_Neoplasm	Childhood Germ Cell Tumor|Childhood Germ Cell Neoplasm|Pediatric Germ Cell Neoplasm|Pediatric Germ Cell Tumor
C7929	Anticipatory_Nausea_and_Vomiting	Nausea_and_Vomiting	Anticipatory Nausea and Vomiting
C7930	Lymphomatoid_Granulomatosis	Angiocentric_Immunoproliferative_Lesion|B-Cell_Proliferation_of_Uncertain_Malignant_Potential	Lymphomatoid Granulomatosis|LYG|lymphomatoid granulomatosis	An angiocentric and angiodestructive lymphoproliferative disease involving extranodal sites, comprised of Epstein-Barr virus (EBV)-positive B-cells admixed with reactive T-cells.  Incidence is higher among adult males; patients with a history of immunodeficiency are at increased risk.  The most common site of involvement is the lung; other common sites include brain, kidney, liver, and skin.  Morphologically, three grades are recognized: grade I, II, and III.  Grade III lymphomatoid granulomatosis should be approached clinically as a subtype of diffuse large B-cell lymphoma. -- 2004
C7931	Grade_I_Lymphomatoid_Granulomatosis	Lymphomatoid_Granulomatosis	Grade I Lymphomatoid Granulomatosis|Angiocentric Immunoproliferative Lesion Grade I|Grade I Angiocentric Immunoproliferative Lesion|Grade I Angiocentric Immunoproliferative Lesions|Grade I LYG
C7932	Grade_II_Lymphomatoid_Granulomatosis	Lymphomatoid_Granulomatosis	Grade II Lymphomatoid Granulomatosis|Angiocentric Immunoproliferative Lesion Grade II|Grade II Angiocentric Immunoproliferative Lesion|Grade II Angiocentric Immunoproliferative Lesions|Grade II LYG
C7933	Grade_III_Lymphomatoid_Granulomatosis	Aggressive_Non-Hodgkin_s_Lymphoma|Diffuse_Large_B-Cell_Lymphoma|Epstein-Barr_Virus-Related_Non-Hodgkin_s_Lymphoma|Lymphomatoid_Granulomatosis	Grade III Lymphomatoid Granulomatosis|Angiocentric Immunoproliferative Lesion Grade III|Grade III Angiocentric Immunoproliferative Lesion|Grade III Angiocentric Immunoproliferative Lesions|Grade III LYG
C7934	Recurrent_Lymphomatoid_Granulomatosis	Lymphomatoid_Granulomatosis|Relapsed_Hematologic_Malignancy	Recurrent Lymphomatoid Granulomatosis|Recurrent Angiocentric Immunoproliferative Lesion|Recurrent LYG|Relapsed Angiocentric Immunoproliferative Lesion
C7935	Recurrent_Kaposi_Sarcoma	Kaposi_s_Sarcoma	Recurrent Kaposi Sarcoma|Recurrent Kaposi's Sarcoma|Recurrent Multiple Hemorrhagic Sarcoma
C7936	Adult_Acute_Myeloid_Leukemia_in_Remission	Acute_Myeloid_Leukemia_in_Remission|Adult_Acute_Leukemia_in_Remission	Adult Acute Myeloid Leukemia in Remission|Adult AML in Remission|Adult ANLL in Remission|Adult Acute Granulocytic Leukemia in Remission|Adult Acute Myeloblastic Leukemia in Remission|Adult Acute Myelogenous Leukemia in Remission|Adult Acute Non-Lymphoblastic Leukemia in Remission|Adult Acute Non-Lymphocytic Leukemia in Remission|Adult Acute NonLymphocytic Leukemia in Remission
C7937	Adult_Acute_Lymphoblastic_Leukemia_in_Remission	Acute_Lymphoblastic_Leukemia_in_Remission|Adult_Acute_Leukemia_in_Remission	Adult Acute Lymphoblastic Leukemia in Remission|Adult ALL in Remission|Adult Acute Lymphocytic Leukemia in Remission|Adult Acute Lymphogenous Leukemia in Remission|Adult Acute Lymphoid Leukemia in Remission
C7938	Childhood_Acute_Lymphoblastic_Leukemia_in_Remission	Acute_Lymphoblastic_Leukemia_in_Remission|Childhood_Acute_Leukemia_in_Remission	Childhood Acute Lymphoblastic Leukemia in Remission|Childhood ALL in Remission|Childhood Acute Lymphocytic Leukemia in Remission|Childhood Acute Lymphogenous Leukemia in Remission|Childhood Acute Lymphoid Leukemia in Remission|Pediatric ALL in Remission|Pediatric Acute Lymphoblastic Leukemia in Remission|Pediatric Acute Lymphocytic Leukemia in Remission|Pediatric Acute Lymphogenous Leukemia in Remission|Pediatric Acute Lymphoid Leukemia in Remission
C7939	Stage_0_Lip_and_Oral_Cavity_Cancer	Lip_and_Oral_Cavity_Carcinoma	Stage 0 Lip and Oral Cavity Cancer|Lip and Oral Cavity Cancer Stage 0|Lip and Oral Cavity Carcinoma Stage 0|Stage 0 Lip and Oral Cavity Carcinoma	Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003
C7940	Childhood_Acute_Monoblastic_Leukemia_and_Acute_Monocytic_Leukemia	Acute_Monoblastic_Leukemia_and_Acute_Monocytic_Leukemia|Childhood_Acute_Myeloid_Leukemia	Childhood Acute Monoblastic Leukemia and Acute Monocytic Leukemia|Childhood Acute Monoblastic and Monocytic Leukemia (M5)
C7941	Body_Temperature_Associated_Symptom	Symptom	Body Temperature Associated Symptom|Body Temperature Associated Condition|Body Temperature Associated Finding|Fever, Chills, and Sweats|Fever, Sweats, Hot Flashes, and Chills
C7942	Adult_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma	Adult_Hodgkin_s_Lymphoma|Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma	Adult Nodular Lymphocyte Predominant Hodgkin's Lymphoma|Adult NLPHD|Adult Nodular Lymphocyte Predominant Hodgkin's Disease
C7943	Adult_Alveolar_Soft_Part_Sarcoma	Alveolar_Soft_Part_Sarcoma	Adult Alveolar Soft Part Sarcoma|Adult Alveolar Soft-Part Sarcoma
C7944	Adult_Epithelioid_Sarcoma	Epithelioid_Sarcoma	Adult Epithelioid Sarcoma
C7946	Malignant_Adult_Hemangiopericytoma	Malignant_Hemangiopericytoma	Malignant Adult Hemangiopericytoma|Adult Malignant Hemangiopericytoma
C7947	Adult_Malignant_Mesenchymoma	Malignant_Mesenchymoma	Adult Malignant Mesenchymoma
C7948	Bronchogenic_Adenocarcinoma	Retired_Concepts	Bronchogenic Adenocarcinoma|Bronchiogenic Adenocarcinoma|Bronchogenic Adenocarcinoma of Lung|Bronchogenic Adenocarcinoma of the Lung|Bronchogenic Lung Adenocarcinoma
C7949	High-Grade_Ductal_Carcinoma_In_Situ_of_the_Breast	Comedocarcinoma|Ductal_Carcinoma_in_situ_of_the_Breast	High Grade Ductal Breast Carcinoma In Situ|Breast Comedocarcinoma|DCIS Grade 3|DIN 3|Ductal Intraepithelial Neoplasia, Grade 3|High-Grade DCIS of Breast|High-Grade DCIS of the Breast|High-Grade Ductal Carcinoma In Situ of Breast
C7950	Invasive_Lobular_Breast_Carcinoma	Invasive_Breast_Carcinoma|Lobular_Breast_Carcinoma	Invasive Lobular Breast Carcinoma|Classic Invasive Lobular Carcinoma|Infiltrating Lobular Adenocarcinoma|Infiltrating Lobular Breast Carcinoma|Infiltrating Lobular Carcinoma of Breast|Infiltrating Lobular Carcinoma of the Breast|Invasive Lobular Adenocarcinoma|Invasive Lobular Carcinoma|Invasive Lobular Carcinoma of Breast|Invasive Lobular Carcinoma of the Breast|Invasive Lobular Carcinoma, Classic Type	An infiltrating lobular adenocarcinoma.  The malignant cells lack cohesion and are arranged individually or in a linear manner (Indian files), or as narrow trabeculae within the stroma.  The malignant cells are usually smaller than those of ductal carcinoma, are less pleomorphic, and have fewer mitotic figures. --2002
C7951	Paget_s_Disease_of_the_Breast_with_Invasive_Ductal_Carcinoma	Invasive_Breast_Carcinoma|Paget_s_Disease_of_the_Breast	Paget's Disease of the Breast with Invasive Ductal Carcinoma|Paget's Disease and Infiltrating Ductal Carcinoma of Breast|Paget's Disease and Infiltrating Ductal Carcinoma of the Breast|Paget's Disease and Invasive Ductal Carcinoma of Breast|Paget's Disease and Invasive Ductal Carcinoma of the Breast|Paget's Disease of Breast with Infiltrating Ductal Carcinoma|Paget's Disease of Breast with Invasive Ductal Carcinoma|Paget's Disease of the Breast with Infiltrating Ductal Carcinoma
C7952	Childhood_Burkitt_s_Leukemia	Burkitt_s_Cell_Leukemia|Childhood_Leukemia	Childhood Burkitt's Leukemia|L3 Childhood ALL|L3 Childhood Acute Lymphoblastic Leukemia|L3 Childhood Acute Lymphocytic Leukemia|L3 Pediatric ALL|L3 Pediatric Acute Lymphoblastic Leukemia|L3 Pediatric Acute Lymphocytic Leukemia|Pediatric Burkitt's Leukemia	The only TdT negative ALL is L3 (Burkitt's).
C7953	Childhood_Precursor_T_Lymphoblastic_Leukemia	Childhood_Acute_Lymphoblastic_Leukemia|Precursor_T_Lymphoblastic_Leukemia	Childhood Precursor T-Lymphoblastic Leukemia|T-Cell Childhood ALL|T-Cell Childhood Acute Lymphoblastic Leukemia|T-Cell Childhood Acute Lymphocytic Leukemia|T-Cell Pediatric ALL|T-Cell Pediatric Acute Lymphoblastic Leukemia|T-Cell Pediatric Acute Lymphocytic Leukemia
C7954	Adult_Burkitt_s_Leukemia	Burkitt_s_Cell_Leukemia	Adult Burkitt's Leukemia|L3 Adult ALL|L3 Adult Acute Lymphoblastic Leukemia|L3 Adult Acute Lymphocytic Leukemia	The only TdT negative ALL is L3 (Burkitt's).
C7955	Childhood_Hepatocellular_Carcinoma	Childhood_Liver_Cancer|Hepatocellular_Carcinoma	Childhood Hepatocellular Carcinoma|Childhood Carcinoma of Liver Cell|Childhood Carcinoma of the Liver Cell|Childhood Hepatoma|Childhood Liver Cell Carcinoma|Pediatric Carcinoma of Liver Cell|Pediatric Carcinoma of the Liver Cell|Pediatric Hepatocellular Carcinoma|Pediatric Hepatoma|Pediatric Liver Cell Carcinoma
C7956	Adult_Hepatocellular_Carcinoma	Adult_Liver_Carcinoma|Hepatocellular_Carcinoma	Adult Hepatocellular Carcinoma|Adult Hepatoma|Adult Primary Carcinoma of Liver Cell|Adult Primary Carcinoma of the Liver Cell|Adult Primary Hepatocellular Carcinoma|Adult Primary Hepatoma|Adult Primary Liver Cell Carcinoma
C7957	Childhood_Embryonal_Rhabdomyosarcoma	Childhood_Rhabdomyosarcoma|Embryonal_Rhabdomyosarcoma	Childhood Embryonal Rhabdomyosarcoma|Embryonal Childhood Rhabdomyosarcoma|Pediatric Embryonal Rhabdomyosarcoma
C7958	Childhood_Alveolar_Rhabdomyosarcoma	Alveolar_Rhabdomyosarcoma|Childhood_Rhabdomyosarcoma	Childhood Alveolar Rhabdomyosarcoma|Alveolar Childhood Rhabdomyosarcoma|Pediatric Alveolar Rhabdomyosarcoma
C7959	Childhood_Pleomorphic_Rhabdomyosarcoma	Childhood_Rhabdomyosarcoma|Pleomorphic_Rhabdomyosarcoma	Childhood Anaplastic Rhabdomyosarcoma|Childhood Pleomorphic Rhabdomyosarcoma|Pediatric Pleomorphic Rhabdomyosarcoma|Pleomorphic Childhood Rhabdomyosarcoma
C7960	Childhood_Mixed_Rhabdomyosarcoma	Childhood_Rhabdomyosarcoma|Mixed_Type_Rhabdomyosarcoma	Childhood Mixed Rhabdomyosarcoma|Childhood Mixed Cell Type Rhabdomyosarcoma|Childhood Mixed Type Rhabdomyosarcoma|Mixed Childhood Rhabdomyosarcoma|Pediatric Mixed Cell Type Rhabdomyosarcoma|Pediatric Mixed Rhabdomyosarcoma|Pediatric Mixed Type Rhabdomyosarcoma
C7961	Adult_Acute_Myeloid_Leukemia_with_Maturation	Acute_Myeloid_Leukemia_with_Maturation|Adult_Acute_Myeloid_Leukemia	Adult Acute Myeloid Leukemia with Maturation|Adult Acute Granulocytic Leukemia with Maturation|Adult Acute M2 Leukemia|Adult Acute Myeloblastic Leukemia with Maturation|Adult Acute Myeloblastic Leukemia with Maturation (M2)|Adult Acute Myelocytic Leukemia with Maturation|Adult Acute Myelogenous Leukemia with Maturation|M2 Adult Acute Granulocytic Leukemia|M2 Adult Acute Granulocytic Leukemia with Maturation|M2 Adult Acute Myeloblastic Leukemia|M2 Adult Acute Myeloblastic Leukemia with Maturation|M2 Adult Acute Myelocytic Leukemia|M2 Adult Acute Myelocytic Leukemia with Maturation|M2 Adult Acute Myelogenous Leukemia|M2 Adult Acute Myelogenous Leukemia with Maturation|M2 Adult Acute Myeloid Leukemia|M2 Adult Acute Myeloid Leukemia with Maturation
C7962	Adult_Acute_Myelomonocytic_Leukemia	Acute_Myelomonocytic_Leukemia|Adult_Acute_Myeloid_Leukemia	Adult Acute Myelomonocytic Leukemia|Adult AMMoL|Adult Acute M4 Leukemia|Adult Acute Myelomonocytic Leukemia (M4)|M4 Adult Acute Leukemia|M4 Adult Acute Myelomonocytic Leukemia
C7963	Adult_Acute_Eosinophilic_Leukemia	Acute_Eosinophilic_Leukemia|Adult_Acute_Myeloid_Leukemia	Adult Acute Eosinophilic Leukemia
C7964	Adult_Acute_Basophilic_Leukemia	Acute_Basophilic_Leukemia|Adult_Acute_Myeloid_Leukemia	Adult Acute Basophilic Leukemia
C7965	Adult_Acute_Megakaryoblastic_Leukemia	Acute_Megakaryoblastic_Leukemia|Adult_Acute_Myeloid_Leukemia	Adult Acute Megakaryoblastic Leukemia|Adult Acute M7 Leukemia|Adult Acute Megakaryocytic Leukemia|Adult Acute Megakaryocytic Leukemia (M7)|M7 Adult Acute Leukemia|M7 Adult Acute Megakaryocytic Leukemia
C7966	Colon_Mucinous_Adenocarcinoma	Colon_Adenocarcinoma|Colorectal_Mucinous_Adenocarcinoma	Colon Mucinous Adenocarcinoma|Colloid Adenocarcinoma of Colon|Colloid Adenocarcinoma of the Colon|Colloid Colon Adenocarcinoma|Colloidal Adenocarcinoma of Colon|Colloidal Adenocarcinoma of the Colon|Colloidal Colon Adenocarcinoma|Colon Colloid Adenocarcinoma|Colon Colloidal Adenocarcinoma|Colonic Colloid Adenocarcinoma|Colonic Colloidal Adenocarcinoma|Colonic Mucinous Adenocarcinoma|Mucinous Adenocarcinoma of Colon|Mucinous Adenocarcinoma of the Colon|Mucinous Colon Adenocarcinoma
C7967	Colon_Signet_Ring_Adenocarcinoma	Colon_Adenocarcinoma|Colorectal_Signet_Ring_Cell_Carcinoma	Colon Signet Ring Cell Adenocarcinoma|Colonic Signet Ring Cell Adenocarcinoma|Signet Ring Cell Adenocarcinoma of Colon|Signet Ring Cell Adenocarcinoma of the Colon|Signet Ring Cell Colon Adenocarcinoma
C7968	Childhood_Acute_Promyelocytic_Leukemia	Acute_Promyelocytic_Leukemia|Childhood_Acute_Myeloid_Leukemia	Childhood Acute Promyelocytic Leukemia|Childhood APL|Childhood Acute M3 Leukemia|Childhood Acute Progranulocytic Leukemia|Childhood Acute Promyelocytic Leukemia (M3)|Childhood M3 APL|M3 Childhood Acute Promyelocytic Leukemia|M3 Pediatric Acute Promyelocytic Leukemia|Pediatric APL|Pediatric Acute M3 Leukemia|Pediatric Acute Progranulocytic Leukemia|Pediatric Acute Promyelocytic Leukemia|Pediatric M3 APL
C7970	Childhood_Acute_Myelomonocytic_Leukemia	Acute_Myelomonocytic_Leukemia|Childhood_Acute_Myeloid_Leukemia	Childhood Acute Myelomonocytic Leukemia|Childhood AMML|Childhood AMMoL|Childhood Acute M4 Leukemia|Childhood Acute Myelomonocytic Leukemia (M4)|M4 Childhood Acute Myelomonocytic Leukemia|M4 Pediatric Acute Myelomonocytic Leukemia|Pediatric AMML|Pediatric AMMoL|Pediatric Acute M4 Leukemia|Pediatric Acute Myelomonocytic Leukemia
C7971	Childhood_Acute_Basophilic_Leukemia	Acute_Basophilic_Leukemia|Childhood_Acute_Myeloid_Leukemia	Childhood Acute Basophilic Leukemia|Pediatric Acute Basophilic Leukemia
C7972	Childhood_Acute_Megakaryoblastic_Leukemia	Acute_Megakaryoblastic_Leukemia|Childhood_Acute_Myeloid_Leukemia	Childhood Acute Megakaryoblastic Leukemia|Childhood Acute M7 Leukemia|Childhood Acute Megakaryocytic Leukemia|Childhood Acute Megakaryocytic Leukemia (M7)|M7 Childhood Acute Megakaryocytic Leukemia|M7 Pediatric Acute Megakaryocytic Leukemia|Pediatric Acute M7 Leukemia|Pediatric Acute Megakaryoblastic Leukemia|Pediatric Acute Megakaryocytic Leukemia
C7973	Rectal_Mucinous_Adenocarcinoma	Colorectal_Mucinous_Adenocarcinoma|Rectal_Adenocarcinoma	Rectal Mucinous Adenocarcinoma|Colloid Adenocarcinoma of Rectum|Colloid Adenocarcinoma of the Rectum|Colloidal Adenocarcinoma of Rectum|Colloidal Adenocarcinoma of the Rectum|Mucinous Adenocarcinoma of Rectum|Mucinous Adenocarcinoma of the Rectum|Rectal Colloid Adenocarcinoma|Rectal Colloidal Adenocarcinoma
C7974	Undifferentiated_Rectal_Carcinoma	Colorectal_Undifferentiated_Carcinoma|Rectal_Carcinoma	Rectal Undifferentiated Carcinoma|Anaplastic Carcinoma of Rectum|Anaplastic Carcinoma of the Rectum|Rectal Anaplastic Carcinoma|Undifferentiated Carcinoma of Rectum|Undifferentiated Carcinoma of the Rectum|Undifferentiated Rectal Carcinoma
C7975	Extrahepatic_Bile_Duct_Adenocarcinoma	Bile_Duct_Adenocarcinoma|Extrahepatic_Bile_Duct_Carcinoma	Extrahepatic Bile Duct Adenocarcinoma|Adenocarcinoma of Extrahepatic Bile Duct|Adenocarcinoma of the Extrahepatic Bile Duct
C7976	Distal_1_3_of_the_Common_Bile_Duct_Adenocarcinoma	Distal_Biliary_Tract_Carcinoma|Extrahepatic_Bile_Duct_Adenocarcinoma	Distal 1/3 of the Common Bile Duct Adenocarcinoma|Adenocarcinoma of Distal 1/3 of Common Bile Duct|Adenocarcinoma of the Distal 1/3 of the Common Bile Duct|Distal 1/3 of Common Bile Duct Adenocarcinoma
C7977	Pancreatic_Acinar_Cell_Carcinoma	Acinar_Cell_Carcinoma|Pancreatic_Adenocarcinoma	Pancreatic Acinar Cell Carcinoma|Acinar Cell Adenocarcinoma of Pancreas|Acinar Cell Adenocarcinoma of the Pancreas|Acinar Cell Carcinoma of Pancreas|Acinar Cell Carcinoma of the Pancreas|Pancreas Acinar Cell Adenocarcinoma|Pancreatic Acinar Cell Adenocarcinoma
C7978	Ovarian_Serous_Cystadenocarcinoma	Ovarian_Cystadenocarcinoma|Ovarian_Serous_Adenocarcinoma|Serous_Cystadenocarcinoma	Ovarian Serous Cystadenocarcinoma
C7979	Ovarian_Endometrioid_Adenocarcinoma	Endometrioid_Carcinoma|Malignant_Ovarian_Endometrioid_Tumor|Ovarian_Adenocarcinoma	Ovarian Endometrioid Adenocarcinoma|Endometrioid Adenocarcinoma of Ovary|Endometrioid Adenocarcinoma of the Ovary|Endometrioid Cancer of Ovary|Endometrioid Cancer of the Ovary|Endometrioid Carcinoma of Ovary|Endometrioid Carcinoma of the Ovary|Ovarian Endometrioid Cancer|Ovarian Endometrioid Carcinoma	Endometrioid adenocarcinoma comprises 10% to 25% of all primary ovarian carcinomas.  Grossly, endometrioid carcinoma may present as a cystic or solid mass.  Microscopically, the tumor resembles greatly the appearance of the ordinary type of endometrial adenocarcinoma.  As a group, endometrioid carcinoma has a prognosis twice as good as that of serous or mucinous carcinoma. --2002
C7980	Ovarian_Clear_Cell_Cystadenocarcinoma	Ovarian_Cystadenocarcinoma	Ovarian Clear Cell Cystadenocarcinoma	A malignant glandular epithelial tumor characterized by the presence of clear and hobnail cells and cystic structures.
C7981	Vaginal_Adenocarcinoma	Adenocarcinoma|Vaginal_Carcinoma|Vaginal_Glandular_Neoplasm	Vaginal Adenocarcinoma|Adenocarcinoma of Vagina|Adenocarcinoma of the Vagina|Vagina Adenocarcinoma
C7982	Cervical_Small_Cell_Carcinoma	Cervical_Carcinoma|Small_Cell_Carcinoma	Cervical Small Cell Carcinoma|Cervix Small Cell Carcinoma|Cervix Uteri Small Cell Carcinoma|Small Cell Carcinoma of Cervix|Small Cell Carcinoma of Cervix Uteri|Small Cell Carcinoma of Uterine Cervix|Small Cell Carcinoma of the Cervix|Small Cell Carcinoma of the Cervix Uteri|Small Cell Carcinoma of the Uterine Cervix|Uterine Cervix Small Cell Carcinoma	Small cell carcinoma originating in the cervix
C7983	Borderline_Ovarian_Endometrioid_Tumor	Borderline_Ovarian_Epithelial_Neoplasm|Ovarian_Endometrioid_Tumor	Borderline Ovarian Endometrioid Tumor|Borderline Endometrioid Adenofibroma|Borderline Endometrioid Cystadenoma|Borderline Endometrioid Neoplasm of Ovary|Borderline Endometrioid Neoplasm of the Ovary|Borderline Endometrioid Tumor of Ovary|Borderline Endometrioid Tumor of the Ovary|Borderline Malignancy Endometrioid Adenofibroma|Borderline Malignancy Endometrioid Cystadenoma|Borderline Ovarian Endometrioid Neoplasm|Endometrioid Neoplasm of Low Malignant Potential|Endometrioid Neoplasm with Proliferating Activity, Ovarian|Endometrioid Tumor of Low Malignant Potential|Endometrioid Tumor with Proliferating Activity, Ovarian|Low Malignancy Potential Endometrioid Cystadenoma|Low Malignant Potential Endometrioid Neoplasm of Ovary|Low Malignant Potential Endometrioid Neoplasm of the Ovary|Low Malignant Potential Endometrioid Tumor of Ovary|Low Malignant Potential Endometrioid Tumor of the Ovary|Low Malignant Potential Ovarian Endometrioid Neoplasm|Low Malignant Potential Ovarian Endometrioid Tumor|Ovarian Endometrioid Borderline Neoplasm|Ovarian Endometrioid Borderline Tumor|Ovarian Endometrioid Neoplasm of Low Malignant Potential|Ovarian Endometrioid Neoplasm with Proliferating Activity|Ovarian Endometrioid Tumor of Low Malignant Potential|Ovarian Endometrioid Tumor with Proliferating Activity|Proliferating Endometrioid Neoplasm of Ovary|Proliferating Endometrioid Neoplasm of the Ovary|Proliferating Endometrioid Tumor of Ovary|Proliferating Endometrioid Tumor of the Ovary|Proliferating Ovarian Endometrioid Neoplasm|Proliferating Ovarian Endometrioid Tumor
C7985	Epithelial_Mesothelioma	Diffuse_Malignant_Mesothelioma	Epithelioid Mesothelioma|Epithelial Mesothelioma|Malignant Epithelial Mesothelioma
C7986	Spindle_Cell_Uveal_Melanoma	Spindle_Cell_Melanoma|Uveal_Melanoma	Spindle Cell Uveal Melanoma|Spindle Cell Intraocular Melanoma|Spindle Cell Melanoma of Uvea|Spindle Cell Melanoma of the Uvea|Uveal Spindle Cell Melanoma	Intraocular Melanoma is derived from melanocytes of the uveal tract.  This tumor is the most common primary intraocular tumor in the United States and Western Europe.  Similar to melanoma of the skin it is rare in Africa and Asia.  Diagnostic procedures include ophthalmoscopic exam, fluorescein angiograph and ultrasound.  Treatment includes: surgical excision of the eye, iridocyclectomy and tumor resection.  Recently treatment as also included radiotherapy or photo coagulation.  Classification of uveal melanomas recognizes four cell types within these tumors. Spindle A and B cells are included in this classification. - 2002
C7987	Spindle_Cell_Type_A_Uveal_Melanoma	Spindle_Cell_Uveal_Melanoma|Type_A_Spindle_Cell_Melanoma	Spindle Cell Type A Uveal Melanoma|Spindle Cell Type A Melanoma of Uvea|Spindle Cell Type A Melanoma of the Uvea|Uveal Spindle Cell Type A Melanoma
C7988	Spindle_Cell_Type_B_Uveal_Melanoma	Spindle_Cell_Uveal_Melanoma|Type_B_Spindle_Cell_Melanoma	Spindle Cell Type B Uveal Melanoma|Spindle Cell Type B Melanoma of Uvea|Spindle Cell Type B Melanoma of the Uvea|Uveal Spindle Cell Type B Melanoma
C7989	Intermediate_Cell_Type_Uveal_Melanoma	Uveal_Melanoma	Intermediate Cell Type Uveal Melanoma|Intermediate Cell Type Intraocular Melanoma|Intraocular Mixed Cell Type Melanoma|Mixed Cell Type Intraocular Melanoma|Mixed Cell Type Melanoma of Uvea|Mixed Cell Type Melanoma of the Uvea|Mixed Cell Type Uveal Melanoma|Uveal Mixed Cell Type Melanoma
C7990	Necrotic_Uveal_Melanoma	Uveal_Melanoma	Necrotic Uveal Melanoma
C7991	Salivary_Gland_Squamous_Cell_Carcinoma	Head_and_Neck_Squamous_Cell_Carcinoma|Salivary_Gland_Carcinoma	Salivary Gland Squamous Cell Carcinoma|Epidermoid Carcinoma of Salivary Gland|Epidermoid Carcinoma of the Salivary Gland|SCC of Salivary Gland|SCC of the Salivary Gland|Salivary Gland Epidermoid Carcinoma|Salivary Gland SCC|Squamous Cell Carcinoma of Salivary Gland|Squamous Cell Carcinoma of the Salivary Gland
C7992	Nasopharyngeal_Squamous_Cell_Carcinoma	Head_and_Neck_Squamous_Cell_Carcinoma|Nasopharyngeal_Carcinoma	Nasopharyngeal Squamous Cell Carcinoma|Epidermoid Carcinoma of Nasopharynx|Epidermoid Carcinoma of the Nasopharynx|Nasopharyngeal Epidermoid Carcinoma|Nasopharyngeal Keratinizing Squamous Cell Carcinoma|Squamous Cell Carcinoma of Nasopharynx|Squamous Cell Carcinoma of the Nasopharynx	Squamous cell carcinoma (keratinizing) of the nasopharynx is defined as a carcinoma having squamous differentiation in the form of intercellular bridges or keratinization over most of its extend (Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999). --2002
C7993	Parathyroid_Clear_Cell_Adenoma	Parathyroid_Adenoma	Parathyroid Gland Clear Cell Adenoma|Clear Cell Adenoma of Parathyroid|Clear Cell Adenoma of Parathyroid Gland|Clear Cell Adenoma of the Parathyroid|Clear Cell Adenoma of the Parathyroid Gland|Parathyroid Clear Cell Adenoma|Parathyroid Gland Transitional Clear Cell Adenoma|Parathyroid Transitional Clear Cell Adenoma|Transitional Clear Cell Adenoma of Parathyroid|Transitional Clear Cell Adenoma of Parathyroid Gland|Transitional Clear Cell Adenoma of the Parathyroid|Transitional Clear Cell Adenoma of the Parathyroid Gland	A parathyroid gland adenoma composed predominantly of neoplastic cells with clear cytoplasm. (NCI05)
C7994	Parathyroid_Mixed_Cell_Type_Adenoma	Mixed_Cell_Adenoma|Parathyroid_Adenoma	Parathyroid Gland Mixed Cell Type Adenoma|Mixed Cell Type Adenoma of Parathyroid|Mixed Cell Type Adenoma of Parathyroid Gland|Mixed Cell Type Adenoma of the Parathyroid|Mixed Cell Type Adenoma of the Parathyroid Gland|Parathyroid Mixed Cell Type Adenoma	A parathyroid gland adenoma that contains a mixture of neoplastic cells (chief cells, oncocytes, and clear cells). (NCI05)
C7995	Granular_Renal_Cell_Carcinoma	Neoplasm_by_Obsolete_Classification	Granular Renal Cell Carcinoma|Granular Cell Carcinoma of Kidney|Granular Cell Carcinoma of the Kidney|Kidney Granular Cell Carcinoma	A renal cell carcinoma with eosinophilic cytoplasm and high nuclear grade.  Granular cells can be seen in any subtype of renal cell carcinoma, including conventional clear cell carcinoma.  This term does not represent a specific subtype of renal cell carcinoma and should no longer be used. -- 2003
C7996	Malignant_Type_B1_Thymoma	Malignant_Thymoma|Thymoma_Type_B1	Malignant Type B1 Thymoma
C7997	Thymoma_Type_B3	Malignant_Thymoma|Thymoma_Type_B	Thymoma Type B3|Atypical Thymoma|Epithelial Malignant Thymoma|Epithelial Thymoma|Malignant Thymoma Type B3|Squamoid Thymoma|Well Differentiated Thymic Carcinoma|Well-Differentiated Thymic Carcinoma	Also known as well-differentiated thymic carcinoma, atypical thymoma, or epithelial thymoma, this type of thymoma displays morphologic characteristics of a well-differentiated carcinoma. --2003
C7998	Lymphoepithelioma-Like_Thymic_Carcinoma	Lymphoepithelioma-Like_Carcinoma|Thymoma_Type_C	Thymic Lymphoepithelioma-Like Carcinoma|Lymphoepithelial Cancer of Thymus|Lymphoepithelial Cancer of the Thymus|Lymphoepithelial Thymus Cancer|Lymphoepithelioma-like Carcinoma of Thymus|Lymphoepithelioma-like Carcinoma of the Thymus|Lymphoepithelioma-like Thymic Carcinoma|Lymphoepithelioma-like Thymus Carcinoma|Malignant Lymphoepithelial Thymoma	A rare, usually aggressive primary thymic carcinoma, characterized by a syncytial growth of undifferentiated carcinoma cells and the presence of a lymphoplasmacytic infiltrate.  More than 40% of cases are associated with Epstein-Barr virus infection. -- 2005
C7999	Malignant_Type_A_Thymoma	Malignant_Thymoma|Thymoma_Type_A	Malignant Type A Thymoma
C8000	Testicular_Yolk_Sac_Tumor	Malignant_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Pure_Testicular_Germ_Cell_Tumor|Yolk_Sac_Tumor	Testicular Yolk Sac Tumor|Endodermal Sinus Neoplasm of Testis|Endodermal Sinus Neoplasm of the Testis|Endodermal Sinus Tumor of Testis|Endodermal Sinus Tumor of the Testis|Testicular Endodermal Sinus Neoplasm|Testicular Endodermal Sinus Tumor|Testicular Yolk Sac Neoplasm|Yolk Sac Neoplasm of Testis|Yolk Sac Neoplasm of the Testis|Yolk Sac Tumor of Testis|Yolk Sac Tumor of the Testis
C8001	Testicular_Mixed_Embryonal_Carcinoma_and_Yolk_Sack_Tumor	Testicular_Mixed_Germ_Cell_Neoplasm	Testicular Mixed Embryonal Carcinoma and Yolk Sack Tumor|Mixed Embryonal Carcinoma and Endodermal Sinus Neoplasm of Testis|Mixed Embryonal Carcinoma and Endodermal Sinus Neoplasm of the Testis|Mixed Embryonal Carcinoma and Endodermal Sinus Tumor of Testis|Mixed Embryonal Carcinoma and Endodermal Sinus Tumor of the Testis|Mixed Embryonal Carcinoma and Yolk Sac Neoplasm of Testis|Mixed Embryonal Carcinoma and Yolk Sac Neoplasm of the Testis|Mixed Embryonal Carcinoma and Yolk Sac Tumor of Testis|Mixed Embryonal Carcinoma and Yolk Sac Tumor of the Testis|Testicular Mixed Embryonal Carcinoma and Endodermal Sinus Neoplasm|Testicular Mixed Embryonal Carcinoma and Endodermal Sinus Tumor|Testicular Mixed Embryonal Carcinoma and Yolk Sac Neoplasm|Testicular Mixed Embryonal Carcinoma and Yolk Sac Tumor
C8002	Testicular_Mixed_Yolk_Sac_Tumor_and_Teratoma	Testicular_Mixed_Germ_Cell_Neoplasm	Testicular Mixed Yolk Sac Tumor and Teratoma|Mixed Endodermal Sinus Neoplasm and Teratoma of Testis|Mixed Endodermal Sinus Neoplasm and Teratoma of the Testis|Mixed Endodermal Sinus Tumor and Teratoma of Testis|Mixed Endodermal Sinus Tumor and Teratoma of the Testis|Mixed Yolk Sac Neoplasm and Teratoma of Testis|Mixed Yolk Sac Neoplasm and Teratoma of the Testis|Mixed Yolk Sac Tumor and Teratoma of Testis|Mixed Yolk Sac Tumor and Teratoma of the Testis|Testicular Mixed Endodermal Sinus Neoplasm and Teratoma|Testicular Mixed Endodermal Sinus Tumor and Teratoma|Testicular Mixed Yolk Sac Neoplasm and Teratoma
C8003	Testicular_Mixed_Yolk_Sac_Tumor_and_Teratoma_with_Seminoma	Testicular_Mixed_Germ_Cell_Neoplasm	Testicular Mixed Yolk Sac Tumor and Teratoma with Seminoma|Mixed Endodermal Sinus Neoplasm and Teratoma with Seminoma of Testis|Mixed Endodermal Sinus Neoplasm and Teratoma with Seminoma of the Testis|Mixed Endodermal Sinus Tumor and Teratoma with Seminoma of Testis|Mixed Endodermal Sinus Tumor and Teratoma with Seminoma of the Testis|Mixed Yolk Sac Neoplasm and Teratoma with Seminoma of Testis|Mixed Yolk Sac Neoplasm and Teratoma with Seminoma of the Testis|Mixed Yolk Sac Tumor and Teratoma with Seminoma of Testis|Mixed Yolk Sac Tumor and Teratoma with Seminoma of the Testis|Testicular Mixed Endodermal Sinus Neoplasm and Teratoma with Seminoma|Testicular Mixed Endodermal Sinus Tumor and Teratoma with Seminoma|Testicular Mixed Yolk Sac Neoplasm and Teratoma with Seminoma
C8006	Pancreatic_Delta_Cell_Somatostatin_Producing_Neoplasm	Delta_Cell_Somatostatin_Producing_Neoplasm|Functioning_Pancreatic_Endocrine_Neoplasm|Pancreatic_Delta_Cell_Neoplasm	Pancreatic Somatostatin Producing Tumor|Pancreatic Delta Cell Tumor|Pancreatic Somatostatin Cell Tumor|Pancreatic Somatostatin Producing Neoplasm|Pancreatic Somatostatinoma|Somatostatinoma of Islet Cells|Somatostatinoma of the Islet Cells	A usually malignant, somatostatin secreting endocrine neoplasm, arising from the delta cells of the pancreas.  It is associated with diabetes mellitus, hypochlorhydia, gallbladder disease, diarrhea, steatorrhea, anaemia, and weight loss.
C8011	Thyroid_Stimulating_Hormone_Secreting_Pituitary_Gland_Adenoma	Pituitary_Gland_Adenoma|Thyroid_Stimulating_Hormone_Producing_Pituitary_Gland_Neoplasm	TSH Producing Pituitary Gland Adenoma|TSH Producing Adenoma of Pituitary|TSH Producing Adenoma of Pituitary Gland|TSH Producing Adenoma of the Pituitary|TSH Producing Adenoma of the Pituitary Gland|TSH Producing Pituitary Adenoma|TSH Secreting Adenoma of Pituitary|TSH Secreting Adenoma of Pituitary Gland|TSH Secreting Adenoma of the Pituitary|TSH Secreting Adenoma of the Pituitary Gland|TSH Secreting Pituitary Adenoma|TSH Secreting Pituitary Gland Adenoma|TSHoma|Thyroid Stimulating Hormone Producing Adenoma of Pituitary|Thyroid Stimulating Hormone Producing Adenoma of Pituitary Gland|Thyroid Stimulating Hormone Producing Adenoma of the Pituitary|Thyroid Stimulating Hormone Producing Adenoma of the Pituitary Gland|Thyroid Stimulating Hormone Producing Pituitary Adenoma|Thyroid Stimulating Hormone Producing Pituitary Gland Adenoma|Thyroid Stimulating Hormone Secreting Adenoma of Pituitary|Thyroid Stimulating Hormone Secreting Adenoma of Pituitary Gland|Thyroid Stimulating Hormone Secreting Adenoma of the Pituitary|Thyroid Stimulating Hormone Secreting Adenoma of the Pituitary Gland|Thyroid Stimulating Hormone Secreting Pituitary Adenoma|Thyroid Stimulating Hormone Secreting Pituitary Gland Adenoma|Thyrotroph Adenoma|Thyrotrophic Adenoma|Thyrotropin Producing Pituitary Gland Adenoma|Thyrotropinoma	A rare adenoma of the anterior lobe of the pituitary gland that produces thyrotropin.  It is usually associated with goiter and hyperthyroidism. (NCI05)
C8012	Low-Grade_Salivary_Gland_Carcinoma	Salivary_Gland_Carcinoma	Low Grade Salivary Gland Carcinoma|Low-Grade Carcinoma of Salivary Gland|Low-Grade Carcinoma of the Salivary Gland
C8013	Salivary_Gland_Acinic_Cell_Carcinoma	Acinar_Cell_Carcinoma|Salivary_Gland_Adenocarcinoma	Salivary Gland Acinic Cell Carcinoma|Acinic Cell Carcinoma of Salivary Gland|Acinic Cell Carcinoma of the Salivary Gland|Acinic Cell Neoplasm of Salivary Gland|Acinic Cell Neoplasm of the Salivary Gland|Acinic Cell Tumor of Salivary Gland|Acinic Cell Tumor of the Salivary Gland|Salivary Gland Acinic Cell Neoplasm|Salivary Gland Acinic Cell Tumor
C8014	Lip_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma|Lip_Carcinoma	Lip Basal Cell Carcinoma|Basal Cell Carcinoma of Lip|Basal Cell Carcinoma of the Lip
C8015	Low-Grade_Salivary_Gland_Mucoepidermoid_Carcinoma	Low-Grade_Salivary_Gland_Carcinoma|Salivary_Gland_Mucoepidermoid_Carcinoma	Low Grade Salivary Gland Mucoepidermoid Carcinoma|Low-Grade Mucoepidermoid Carcinoma of Salivary Gland|Low-Grade Mucoepidermoid Carcinoma of the Salivary Gland
C8016	Grade_I_Salivary_Gland_Mucoepidermoid_Carcinoma	Salivary_Gland_Mucoepidermoid_Carcinoma	Grade I Salivary Gland Mucoepidermoid Carcinoma|Grade I Mucoepidermoid Carcinoma of Salivary Gland|Grade I Mucoepidermoid Carcinoma of the Salivary Gland
C8017	Grade_II_Salivary_Gland_Mucoepidermoid_Carcinoma	Salivary_Gland_Mucoepidermoid_Carcinoma	Grade II Salivary Gland Mucoepidermoid Carcinoma|Grade II Mucoepidermoid Carcinoma of Salivary Gland|Grade II Mucoepidermoid Carcinoma of the Salivary Gland
C8018	High-Grade_Salivary_Gland_Carcinoma	Salivary_Gland_Carcinoma	High Grade Salivary Gland Carcinoma|High-Grade Carcinoma of Salivary Gland|High-Grade Carcinoma of the Salivary Gland
C8019	High-Grade_Salivary_Gland_Mucoepidermoid_Carcinoma	High-Grade_Salivary_Gland_Carcinoma|Salivary_Gland_Mucoepidermoid_Carcinoma	High Grade Salivary Gland Mucoepidermoid Carcinoma|High-Grade Mucoepidermoid Carcinoma of Salivary Gland|High-Grade Mucoepidermoid Carcinoma of the Salivary Gland
C8020	Grade_III_Salivary_Gland_Mucoepidermoid_Carcinoma	Salivary_Gland_Mucoepidermoid_Carcinoma	Grade III Salivary Gland Mucoepidermoid Carcinoma|Grade III Mucoepidermoid Carcinoma of Salivary Gland|Grade III Mucoepidermoid Carcinoma of the Salivary Gland
C8021	Salivary_Gland_Adenocarcinoma	Adenocarcinoma|Salivary_Gland_Carcinoma	Salivary Gland Adenocarcinoma|Adenocarcinoma of Salivary Gland|Adenocarcinoma of the Salivary Gland
C8022	Poorly_Differentiated_Salivary_Gland_Carcinoma	Salivary_Gland_Carcinoma	Poorly Differentiated Salivary Gland Carcinoma|Poorly Differentiated Carcinoma of the Salivary Gland|Salivary Gland Poorly Differentiated Carcinoma
C8023	Nasopharyngeal_Undifferentiated_Carcinoma	Epstein-Barr_Virus-Related_Carcinoma|Nasopharyngeal_Carcinoma|Nasopharyngeal_Type_Undifferentiated_Carcinoma	Nasopharyngeal Undifferentiated Carcinoma|Lymphoepithelioma of Nasopharynx|Lymphoepithelioma of the Nasopharynx|Nasopharyngeal Lymphoepithelioma|Nasopharyngeal Nonkeratinizing Undifferentiated Carcinoma|Undifferentiated Carcinoma of Nasopharynx|Undifferentiated Carcinoma of the Nasopharynx	Undifferentiated nasopharyngeal carcinoma (lymphoepithelioma) is defined as a carcinoma with cytologically uniform cells with ovoid vesicular nuclei, prominent nucleoli, and indistinct cell borders resulting in a syncytial pattern.  Usually, an inflammatory infiltrate rich in mature lymphocytes and occasionally eosinophiles is also present (Sternberg's Diagnostic Surgical Pathology, 3rd ed., 1999). --2002
C8024	Undifferentiated_Salivary_Gland_Carcinoma	Salivary_Gland_Carcinoma	Undifferentiated Salivary Gland Carcinoma|Anaplastic Carcinoma of Salivary Gland|Anaplastic Carcinoma of the Salivary Gland|Anaplastic Salivary Gland Carcinoma|Salivary Gland Anaplastic Carcinoma|Undifferentiated Carcinoma of Salivary Gland|Undifferentiated Carcinoma of the Salivary Gland
C8025	Malignant_Mixed_Tumor_of_the_Salivary_Gland	Malignant_Mixed_Neoplasm|Malignant_Salivary_Gland_Neoplasm|Mixed_Tumor_of_the_Salivary_Gland	Malignant Mixed Tumor of the Salivary Gland|Malignant Mixed Cell Type Neoplasm of Salivary Gland|Malignant Mixed Cell Type Neoplasm of the Salivary Gland|Malignant Mixed Neoplasm of Salivary Gland|Malignant Mixed Neoplasm of the Salivary Gland|Malignant Mixed Tumor of Salivary Gland|Malignant Salivary Gland Mixed Cell Type Neoplasm|Malignant Salivary Gland Mixed Cell Type Tumor|Malignant Salivary Gland Mixed Neoplasm|Malignant Salivary Gland Mixed Tumor|Mixed Malignant Neoplasm of Salivary Gland|Mixed Malignant Neoplasm of the Salivary Gland|Mixed Malignant Salivary Gland Neoplasm|Mixed Malignant Salivary Gland Tumor|Mixed Malignant Tumor of Salivary Gland|Mixed Malignant Tumor of the Salivary Gland
C8026	Salivary_Gland_Adenoid_Cystic_Carcinoma	Adenoid_Cystic_Carcinoma|Salivary_Gland_Carcinoma	Salivary Gland Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Salivary Gland|Adenoid Cystic Carcinoma of the Salivary Gland
C8027	Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Squamous_Differentiation	Adenocarcinoma_with_Squamous_Metaplasia|Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Metaplastic_Changes	Endometrial Endometrioid Adenocarcinoma with Squamous Differentiation|Adenocanthoma of Endometrium|Adenocanthoma of the Endometrium|Endometrial Adenoacanthoma
C8028	Endometrial_Clear_Cell_Carcinoma	Clear_Cell_Adenocarcinoma|Type_II_Endometrial_Adenocarcinoma	Endometrial Clear Cell Adenocarcinoma|Clear Cell Carcinoma of Endometrium|Clear Cell Carcinoma of the Endometrium	A high-grade endometrial adenocarcinoma characterized by the presence of large neoplastic cells that display at least focal cytoplasmic clearing.  The neoplastic cells form papillary, glandular, or sheet-like structures. -- 2004
C8029	Progressive_Hairy_Cell_Leukemia_Initial_Treatment	Hairy_Cell_Leukemia	Progressive Hairy Cell Leukemia Initial Treatment|Progressive Hairy Cell Leukemia, Initial Treatment
C8030	Refractory_Hairy_Cell_Leukemia	Hairy_Cell_Leukemia|Refractory_Hematologic_Malignancy	Refractory Hairy Cell Leukemia|Hairy Cell Leukemia, Refractory
C8031	Negative_Axillary_Lymph_Node	Negative_Lymph_Node	Negative Axillary Lymph Node|No Positive Axillary Nodes|Node-Negative|axillary nodes, no positive|negative axillary lymph nodes|node-negative	Cancer that has not spread to the lymph nodes.
C8032	One_or_More_Positive_Axillary_Nodes	Positive_Axillary_Lymph_Node	One or More Positive Axillary Nodes|1 or More Positive Axillary Nodes|Axillary Node, 1 or More Positive|Positive Axillary Node, 1 or More	Presence of one or more lymph nodes in the area of the armpit in which cancerous cells have been detected.
C8033	Stage_I_Lip_and_Oral_Cavity_Cancer	Lip_and_Oral_Cavity_Carcinoma	Stage I Lip and Oral Cavity Cancer|Lip and Oral Cavity Cancer Stage I|Lip and Oral Cavity Carcinoma Stage I|Stage I Lip and Oral Cavity Carcinoma|stage I lip and oral cavity cancer	Cancer that is no larger than 2 centimeters (about 1 inch) and has not spread to nearby lymph nodes.
C8034	Stage_II_Lip_and_Oral_Cavity_Cancer	Lip_and_Oral_Cavity_Carcinoma	Stage II Lip and Oral Cavity Cancer|Lip and Oral Cavity Cancer Stage II|Lip and Oral Cavity Carcinoma Stage II|Stage II Lip and Oral Cavity Carcinoma|stage II lip and oral cavity cancer	Cancer that is larger than 2 centimeters (about 1 inch) but smaller than 4 centimeters (about 2 inches) and has not spread to lymph nodes in the area.
C8035	Stage_III_Lip_and_Oral_Cavity_Cancer	Lip_and_Oral_Cavity_Carcinoma	Stage III Lip and Oral Cavity Cancer|Lip and Oral Cavity Cancer Stage III|Lip and Oral Cavity Carcinoma Stage III|Stage III Lip and Oral Cavity Carcinoma|stage III lip and oral cavity cancer	Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0). T3: Tumor more than 4 cm in greatest dimension. N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. M0: No distant metastasis. (AJCC 6th ed.) - 2003
C8036	Stage_IV_Lip_and_Oral_Cavity_Cancer	Lip_and_Oral_Cavity_Carcinoma	Stage IV Lip and Oral Cavity Cancer|Lip and Oral Cavity Cancer Stage IV|Lip and Oral Cavity Carcinoma Stage IV|Metastatic Lip and Oral Cavity Cancer|Stage IV Lip and Oral Cavity Carcinoma|stage IV lip and oral cavity cancer	The cancer has spread to tissues around the lip and oral cavity (the lymph nodes in the area may contain cancer); the cancer is any size and has spread to more than one lymph node on the same side of the neck as the cancer, to lymph nodes on one or both sides of the neck, or to any lymph node that is larger than 6 centimeters (larger than 2 inches); or the cancer has spread to other parts of the body.
C8037	Recurrent_Lip_and_Oral_Cavity_Cancer	Lip_and_Oral_Cavity_Carcinoma|Recurrent_Malignant_Oral_Neoplasm	Recurrent Lip and Oral Cavity Cancer|Recurrent Lip and Oral Cavity Carcinoma	The reemergence of lip and/or oral cavity cancer after a period of remission.
C8038	Stage_I_Hypopharyngeal_Carcinoma	Hypopharyngeal_Carcinoma	Stage I Hypopharyngeal Carcinoma|Stage I Carcinoma of Hypopharynx|Stage I Carcinoma of the Hypopharynx|Stage I Hypopharynx Carcinoma|stage I hypopharynx cancer	Stage I includes: T1, N0, M0.  T1: Tumor limited to one subsite of the hypopharynx and 2 cm or less in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003
C8039	Stage_II_Hypopharyngeal_Carcinoma	Hypopharyngeal_Carcinoma	Stage II Hypopharyngeal Carcinoma|Stage II Carcinoma of Hypopharynx|Stage II Carcinoma of the Hypopharynx|Stage II Hypopharynx Carcinoma|stage II hypopharynx cancer	Cancer that involves more than one area of the hypopharynx or is between 2 and 4 centimeters (between 0.75 and 1.5 inches).
C8040	Stage_III_Hypopharyngeal_Carcinoma	Hypopharyngeal_Carcinoma	Stage III Hypopharyngeal Carcinoma|Stage III Carcinoma of Hypopharynx|Stage III Carcinoma of the Hypopharynx|Stage III Hypopharynx Carcinoma|stage III hypopharynx cancer	Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0) (T3, N1, M0).  T3: Tumor more than 4 cm in greatest dimension or with fixation of hemilarynx.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension. M0: No distant metastasis. (AJCC 6th ed.)- 2003
C8041	Stage_I_Laryngeal_Cancer	Laryngeal_Carcinoma	Stage I Laryngeal Cancer|Laryngeal Cancer, Stage I|Stage I Carcinoma of Larynx|Stage I Carcinoma of the Larynx|Stage I Laryngeal Carcinoma|Stage I Larynx Carcinoma|stage I laryngeal cancer	Cancer that is only in the area where it started and has not spread to nearby lymph nodes or other parts of the body. The exact definition of stage I depends on whether the cancer started in the supraglottis (cancer in only one area of the supraglottis, and the vocal cords can move normally); the glottis (cancer in only the vocal cords, and the vocal cords can move normally); or the subglottis (cancer that has not spread outside the subglottis).
C8042	Stage_II_Laryngeal_Cancer	Laryngeal_Carcinoma	Stage II Laryngeal Cancer|Laryngeal Cancer, Stage II|Stage II Carcinoma of Larynx|Stage II Carcinoma of the Larynx|Stage II Laryngeal Carcinoma|Stage II Larynx Carcinoma|stage II laryngeal cancer	Cancer that is found in the larynx only and has not spread to lymph nodes in the area or to other parts of the body. The exact definition of stage II depends on whether the cancer started in the supraglottis (cancer is in more than one area of the supraglottis, but the vocal cords can move normally); the glottis (cancer has spread to the supraglottis, the subglottis, or both, and the vocal cords may not be able to move normally); or the subglottis (cancer has spread to the vocal cords, which may not be able to move normally).
C8043	Stage_III_Laryngeal_Cancer	Laryngeal_Carcinoma	Stage III Laryngeal Cancer|Laryngeal Cancer, Stage III|Stage III Carcinoma of Larynx|Stage III Carcinoma of the Larynx|Stage III Laryngeal Carcinoma|Stage III Larynx Carcinoma|stage III laryngeal cancer	Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N1, M0).  T3: (Supraglottis) Tumor limited to larynx with vocal cord fixation and/or invades any of the following: postcricoid area, pre-epiglottic tissues, paraglottic space, and/or minor thyroid cartilage erosion (e.g., inner cortex).  (Glottis) Tumor limited to the larynx with vocal cord fixation and/or invades paraglottic space, and or minor thyroid cartilage erosion (e.g., inner cortex).  (Subglottis)Tumor limited to larynx with vocal cord fixation.  N0: No regional lymph node metastasis.  N1: Metastasis in a single ipsilateral lymph node, more than 3cm but not more than 6cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C8045	Regional_Pheochromocytoma	Pheochromocytoma	Regional Adrenal Gland Pheochromocytoma|Regional Adrenal Gland Chromaffin Neoplasm|Regional Adrenal Gland Chromaffin Paraganglioma|Regional Adrenal Gland Chromaffin Tumor|Regional Adrenal Gland Chromaffinoma	A pheochromocytoma that invades surrounding tissues adjacent to the adrenal glands. (NCI05)
C8046	Metastatic_Pheochromocytoma	Malignant_Pheochromocytoma	Metastatic Adrenal Gland Pheochromocytoma|Metastatic Adrenal Gland Chromaffin Neoplasm|Metastatic Adrenal Gland Chromaffin Paraganglioma|Metastatic Adrenal Gland Chromaffin Tumor|Metastatic Adrenal Gland Chromaffinoma	A pheochromocytoma that has metastasized to other anatomic sites. (NCI05)
C8047	Recurrent_Pheochromocytoma	Pheochromocytoma	Recurrent Adrenal Gland Pheochromocytoma|Recurrent Adrenal Gland Chromaffin Neoplasm|Recurrent Adrenal Gland Chromaffin Paraganglioma|Recurrent Adrenal Gland Chromaffin Tumor|Recurrent Adrenal Gland Chromaffinoma|Relapsed Adrenal Gland Chromaffin Neoplasm|Relapsed Adrenal Gland Chromaffin Paraganglioma|Relapsed Adrenal Gland Chromaffin Tumor|Relapsed Adrenal Gland Chromaffinoma|Relapsed Adrenal Gland Pheochromocytoma	The reemergence of a pheochromocytoma following surgical removal. (NCI05)
C8048	Stage_I_Oropharyngeal_Carcinoma	Oropharyngeal_Carcinoma	Stage I Oropharyngeal Carcinoma|Oropharyngeal Cancer, Stage I|Stage I Carcinoma of Oropharynx|Stage I Carcinoma of the Oropharynx|Stage I Oropharyngeal Cancer|Stage I Oropharynx Carcinoma|stage I oropharynx cancer	Cancer that is no larger than 2 centimeters (about 0.75 inch) and is confined to the oropharynx.
C8049	Stage_II_Oropharyngeal_Carcinoma	Oropharyngeal_Carcinoma	Stage II Oropharyngeal Carcinoma|Oropharyngeal Cancer, Stage II|Stage II Carcinoma of Oropharynx|Stage II Carcinoma of the Oropharynx|Stage II Oropharyngeal Cancer|Stage II Oropharynx Carcinoma|stage II oropharynx cancer	Stage II includes: T2, N0, M0.  T2: Tumor more than 2 cm but not more than 4 cm in greatest dimension.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C8050	Stage_III_Oropharyngeal_Carcinoma	Oropharyngeal_Carcinoma	Stage III Oropharyngeal Carcinoma|Oropharyngeal Cancer, Stage III|Stage III Carcinoma of Oropharynx|Stage III Carcinoma of the Oropharynx|Stage III Oropharyngeal Cancer|Stage III Oropharynx Carcinoma|stage III oropharynx cancer	Stage III includes: (T3, N0, M0); (T1, N1, M0); (T2, N1, M0); (T3, N2, M0).  T3: Tumor more than 4 cm in greatest dimension.  N1: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension. N2: Metastasis in a single ipsilateral lymph node, more than 3 cm but not more than 6 cm in greatest dimension, or in multiple ipsilateral lymph nodes, none more than 6cm in greatest dimension, or in bilateral or contralateral lymph nodes, none more than 6cm in greatest dimension.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C8051	Recurrent_Oropharyngeal_Cancer	Oropharyngeal_Carcinoma|Recurrent_Pharyngeal_Cancer	Recurrent Oropharyngeal Cancer|Oropharyngeal Cancer, Recurrent|Recurrent Cancer of Oropharynx|Recurrent Cancer of the Oropharynx|Recurrent Carcinoma of Oropharynx|Recurrent Carcinoma of the Oropharynx|Recurrent Oropharynx Carcinoma|Relapsed Cancer of Oropharynx|Relapsed Cancer of the Oropharynx|Relapsed Carcinoma of Oropharynx|Relapsed Carcinoma of the Oropharynx|Relapsed Oropharyngeal Cancer|Relapsed Oropharyngeal Carcinoma|Relapsed Oropharynx Carcinoma	The reemergence of oropharyngeal cancer after a period of remission.
C8052	Oral_Complications_of_Cancer_and_Cancer_Therapy	Complication	Oral Complications of Cancer and Cancer Therapy
C8053	Malignant_Ovarian_Sex_Cord-Stromal_Tumor	Malignant_Ovarian_Neoplasm|Ovarian_Sex_Cord-Stromal_Tumor	Malignant Ovarian Sex Cord-Stromal Tumor|Malignant Ovarian Sex Cord-Stromal Neoplasm|Malignant Sex Cord-Stromal Tumor of Ovary|Malignant Sex Cord-Stromal Tumor of the Ovary	A malignant neoplasm of the ovary.  Overall, sex cord-stromal tumors comprise about 5% of all ovarian neoplasms.
C8054	Follicular_Thyroid_Carcinoma	Well-differentiated_Thyroid_Carcinoma	Thyroid Gland Follicular Carcinoma|Follicular Adenocarcinoma|Follicular Cancer of Thyroid|Follicular Cancer of Thyroid Gland|Follicular Cancer of the Thyroid|Follicular Cancer of the Thyroid Gland|Follicular Carcinoma|Follicular Carcinoma of Thyroid|Follicular Carcinoma of Thyroid Gland|Follicular Carcinoma of the Thyroid|Follicular Carcinoma of the Thyroid Gland|Follicular Thyroid Cancer|Follicular Thyroid Carcinoma|Follicular Thyroid Gland Carcinoma|Thyroid Follicular Carcinoma|Well-Differentiated Follicular Adenocarcinoma|Well-Differentiated Follicular Carcinoma|follicular thyroid cancer	(fo-LIK-yu-ler) Cancer that develops from cells in the follicular areas of the thyroid. One of the slow-growing, highly treatable types of thyroid cancer.
C8055	Stage_II_Pediatric_Hodgkin_s_Lymphoma	Childhood_Hodgkin_s_Lymphoma|Stage_II_Hodgkin_s_Lymphoma	Stage II Childhood Hodgkin's Lymphoma|Childhood Hodgkin's Disease Stage II|Childhood Hodgkin's Lymphoma Stage II|Pediatric Hodgkin's Disease Stage II|Pediatric Hodgkin's Lymphoma Stage II|Stage II Pediatric Hodgkin's Lymphoma
C8056	Stage_I_Pediatric_Hodgkin_s_Lymphoma	Childhood_Hodgkin_s_Lymphoma|Stage_I_Hodgkin_s_Lymphoma	Stage I Childhood Hodgkin's Lymphoma|Childhood Hodgkin's Disease Stage I|Childhood Hodgkin's Lymphoma Stage I|Pediatric Hodgkin's Disease Stage I|Pediatric Hodgkin's Lymphoma Stage I|Stage I Childhood Hodgkin's Disease|Stage I Pediatric Hodgkin's Disease|Stage I Pediatric Hodgkin's Lymphoma
C8057	Stage_III_Pediatric_Hodgkin_s_Lymphoma	Childhood_Hodgkin_s_Lymphoma|Stage_III_Hodgkin_s_Lymphoma	Stage III Childhood Hodgkin's Lymphoma|Childhood Hodgkin's Disease Stage III|Childhood Hodgkin's Lymphoma Stage III|Pediatric Hodgkin's Disease Stage III|Pediatric Hodgkin's Lymphoma Stage III|Stage III Pediatric Hodgkin's Lymphoma
C8058	Stage_IV_Pediatric_Hodgkin_s_Lymphoma	Childhood_Hodgkin_s_Lymphoma|Stage_IV_Hodgkin_s_Lymphoma	Stage IV Childhood Hodgkin's Lymphoma|Childhood Hodgkin's Disease Stage IV|Childhood Hodgkin's Lymphoma Stage IV|Pediatric Hodgkin's Disease Stage IV|Pediatric Hodgkin's Lymphoma Stage IV|Stage IV Pediatric Hodgkin Lymphoma|Stage IV Pediatric Hodgkin's Lymphoma
C8059	Recurrent_Childhood_Hodgkin_s_Lymphoma	Childhood_Hodgkin_s_Lymphoma|Recurrent_Hodgkin_s_Lymphoma	Recurrent Childhood Hodgkin's Lymphoma|Recurrent Childhood Hodgkin Lymphoma|Recurrent Childhood Hodgkin's Disease|Recurrent Pediatric Hodgkin's Disease|Recurrent Pediatric Hodgkin's Lymphoma|Relapsed Childhood Hodgkin's Disease|Relapsed Childhood Hodgkin's Lymphoma|Relapsed Pediatric Hodgkin's Disease|Relapsed Pediatric Hodgkin's Lymphoma
C8060	Childhood_Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma	Childhood_Hodgkin_s_Lymphoma|Nodular_Lymphocyte_Predominant_Hodgkin_s_Lymphoma	Childhood Nodular Lymphocyte Predominant Hodgkin's Lymphoma|Childhood NLPHD|Childhood Nodular Lymphocyte Predominant Hodgkin's Disease|Pediatric NLPHD|Pediatric Nodular Lymphocyte Predominant Hodgkin's Disease|Pediatric Nodular Lymphocyte Predominant Hodgkin's Lymphoma
C8061	Childhood_Lymphocyte_Depleted_Hodgkin_s_Lymphoma	Childhood_Hodgkin_s_Lymphoma|Lymphocyte_Depleted_Hodgkin_s_Lymphoma	Childhood Lymphocyte Depleted Hodgkin's Lymphoma|Childhood HDLD|Childhood LDHD|Childhood Lymphocyte Depletion Hodgkin's Disease|Childhood Lymphocyte Depletion Hodgkin's Lymphoma|Pediatric HDLD|Pediatric LDHD|Pediatric Lymphocyte Depleted Hodgkin's Lymphoma|Pediatric Lymphocyte Depletion Hodgkin's Disease|Pediatric Lymphocyte Depletion Hodgkin's Lymphoma
C8062	Childhood_Nodular_Sclerosis_Hodgkin_s_Lymphoma	Childhood_Hodgkin_s_Lymphoma|Nodular_Sclerosis_Hodgkin_s_Lymphoma	Childhood Nodular Sclerosis Hodgkin's Lymphoma|Childhood Hodgkin's Nodular Sclerosis|Childhood NSHD|Childhood Nodular Sclerosis Hodgkin Lymphoma|Childhood Nodular Sclerosis Hodgkin's Disease|Pediatric Hodgkin's Nodular Sclerosis|Pediatric NSHD|Pediatric Nodular Sclerosis Hodgkin's Disease|Pediatric Nodular Sclerosis Hodgkin's Lymphoma
C8063	Childhood_Mixed_Cellularity_Hodgkin_s_Lymphoma	Childhood_Hodgkin_s_Lymphoma|Mixed_Cellularity_Hodgkin_s_Lymphoma	Childhood Mixed Cellularity Hodgkin's Lymphoma|Childhood HDMC|Childhood MCHD|Childhood Mixed Cellularity Hodgkin Lymphoma|Childhood Mixed Cellularity Hodgkin's Disease|Pediatric HDMC|Pediatric MCHD|Pediatric Mixed Cellularity Hodgkin's Disease|Pediatric Mixed Cellularity Hodgkin's Lymphoma
C8064	Metastatic_Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter	Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter	Metastatic Urothelial Carcinoma of the Renal Pelvis and Ureter|Metastatic Transitional Cell Cancer of Renal Pelvis and Ureter|Metastatic Transitional Cell Cancer of the Renal Pelvis and Ureter|Metastatic Transitional Cell Carcinoma of Renal Pelvis and Ureter
C8065	Primary_Childhood_Soft_Tissue_Sarcoma	Childhood_Soft_Tissue_Sarcoma	Primary Childhood Soft Tissue Sarcoma|Non-Metastatic Childhood Soft Tissue Sarcoma|Non-Metastatic Pediatric Soft Tissue Sarcoma|Nonmetastatic Childhood Soft Tissue Sarcoma
C8066	Metastatic_Childhood_Soft_Tissue_Sarcoma	Childhood_Soft_Tissue_Sarcoma	Metastatic Childhood Soft Tissue Sarcoma|Metastatic Childhood Sarcoma of Soft Tissue|Metastatic Childhood Sarcoma of the Soft Tissue|Metastatic Pediatric Sarcoma of Soft Tissue|Metastatic Pediatric Sarcoma of the Soft Tissue|Metastatic Pediatric Soft Tissue Sarcoma
C8067	Recurrent_Childhood_Soft_Tissue_Sarcoma	Childhood_Soft_Tissue_Sarcoma	Recurrent Childhood Soft Tissue Sarcoma|Recurrent Childhood Sarcoma of Soft Tissue|Recurrent Childhood Sarcoma of the Soft Tissue|Recurrent Pediatric Sarcoma of Soft Tissue|Recurrent Pediatric Sarcoma of the Soft Tissue|Recurrent Pediatric Soft Tissue Sarcoma|Relapsed Childhood Sarcoma of Soft Tissue|Relapsed Childhood Sarcoma of the Soft Tissue|Relapsed Childhood Soft Tissue Sarcoma|Relapsed Pediatric Sarcoma of Soft Tissue|Relapsed Pediatric Sarcoma of the Soft Tissue|Relapsed Pediatric Soft Tissue Sarcoma
C8068	Adult_Non-Hodgkin_s_Lymphoma_Stage	Lymphoma_by_Working_Formulation_Antiquated	Adult Non-Hodgkin's Lymphoma Stage|Adult Non-Hodgkins Lymphoma Stage|Adult NonHodgkin's Lymphoma Stage|Adult NonHodgkins Lymphoma Stage|Stage Adult Non-Hodgkin's Lymphoma
C8069	Stage_I_Low-Grade_Adult_Non-Hodgkin_s_Lymphoma	Low-Grade_Adult_Non-Hodgkin_s_Lymphoma	Stage I Low Grade Adult Non-Hodgkin's Lymphoma
C8070	Stage_I_Small_Lymphocytic_Lymphoma	Small_Lymphocytic_Lymphoma|Stage_I_B-Cell_Non-Hodgkin_s_Lymphoma	Stage I Small Lymphocytic Lymphoma|B-Cell Small Lymphocytic Lymphoma Stage I|Small Lymphocytic Lymphoma Stage I|Stage I B-Cell Small Lymphocytic Lymphoma	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C8071	Stage_I_Grade_1_Follicular_Lymphoma	Grade_1_Follicular_Lymphoma|Stage_I_Follicular_Lymphoma	Stage I Grade 1 Follicular Lymphoma|Follicular Small Cleaved Cell Lymphoma Stage I|Grade I Follicular Lymphoma Stage I|Grade I Follicular Small Cleaved Cell Lymphoma Stage I|Stage I Follicular Small Cleaved Cell Lymphoma|Stage I Grade I Follicular Lymphoma|Stage I Grade I Follicular Small Cleaved Cell Lymphoma
C8072	Stage_I_Grade_2_Follicular_Lymphoma	Grade_2_Follicular_Lymphoma|Stage_I_Follicular_Lymphoma	Stage I Grade 2 Follicular Lymphoma|Follicular Mixed Cell Lymphoma Stage I|Grade II Follicular Lymphoma Stage I|Grade II Follicular Mixed Cell Lymphoma Stage I|Stage I Follicular Mixed Cell Lymphoma|Stage I Grade II Follicular Lymphoma|Stage I Grade II Follicular Mixed Cell Lymphoma
C8073	Stage_I_Grade_3_Follicular_Lymphoma	Grade_3_Follicular_Lymphoma|Stage_I_Follicular_Lymphoma	Stage I Grade 3 Follicular Lymphoma|Follicular Large Cell Lymphoma Stage I|Follicular Lymphoma Grade III Stage I|Grade III Follicular Lymphoma Stage I|Stage I Follicular Large Cell Lymphoma|Stage I Grade III Follicular Large Cell Lymphoma|Stage I Grade III Follicular Lymphoma
C8074	Stage_I_Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma	Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma	Stage I Intermediate Grade Adult Non-Hodgkin's Lymphoma
C8075	Stage_I_Adult_Diffuse_Small_Cleaved_Cell_Lymphoma	Adult_Diffuse_Small_Cleaved_Cell_Lymphoma	Stage I Adult Diffuse Small Cleaved Cell Lymphoma|Adult Diffuse Small Cleaved Cell Lymphoma Stage I
C8076	Stage_I_Adult_Diffuse_Mixed_Cell_Lymphoma	Adult_Diffuse_Mixed_Cell_Lymphoma	Stage I Adult Diffuse Mixed Cell Lymphoma|Adult Diffuse Mixed Cell Lymphoma Stage I
C8077	Stage_I_Adult_Diffuse_Large_Cell_Lymphoma	Adult_Diffuse_Large_Cell_Lymphoma	Stage I Adult Diffuse Large Cell Lymphoma|Adult Diffuse Large Cell Lymphoma Stage I
C8078	Stage_I_Adult_Immunoblastic_Lymphoma	Adult_Immunoblastic_Lymphoma|Stage_I_Diffuse_Large_B-Cell_Lymphoma	Stage I Adult Immunoblastic Lymphoma|Adult Immunoblastic Large Cell Lymphoma Stage I|Stage I Adult Immunoblastic Large Cell Lymphoma
C8079	Stage_I_Adult_Lymphoblastic_Lymphoma	Adult_Lymphoblastic_Lymphoma	Stage I Adult Lymphoblastic Lymphoma|Adult Lymphoblastic Lymphoma Stage I|Adult Stage I Lymphoblastic Lymphoma
C8080	Stage_I_Adult_Burkitt_s_Lymphoma	Adult_Burkitt_s_Lymphoma|Stage_I_Burkitt_s_Lymphoma	Stage I Adult Burkitt's Lymphoma|Adult Diffuse Small Non-Cleaved Cell Lymphoma Stage I|Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma Stage I|Stage I Adult Burkitt Lymphoma|Stage I Adult Diffuse Small Non-Cleaved Cell Lymphoma|Stage I Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma
C8081	Stage_I_High-Grade_Adult_Non-Hodgkin_s_Lymphoma	High-Grade_Adult_Non-Hodgkin_s_Lymphoma	Stage I High Grade Adult Non-Hodgkin's Lymphoma
C8082	Stage_II_Low_Grade_Adult_Non-Hodgkin_s_Lymphoma	Low-Grade_Adult_Non-Hodgkin_s_Lymphoma	Stage II Low Grade Adult Non-Hodgkin's Lymphoma
C8083	Stage_I_Ovarian_Germ_Cell_Tumor	Malignant_Ovarian_Germ_Cell_Tumor	Stage I Ovarian Germ Cell Tumor|Stage I Malignant Germ Cell Neoplasm of Ovary|Stage I Malignant Germ Cell Neoplasm of the Ovary|Stage I Malignant Germ Cell Tumor of Ovary|Stage I Malignant Germ Cell Tumor of the Ovary|Stage I Malignant Ovarian Germ Cell Neoplasm
C8084	Stage_II_Ovarian_Germ_Cell_Tumor	Malignant_Ovarian_Germ_Cell_Tumor	Stage II Ovarian Germ Cell Tumor|Stage II Malignant Germ Cell Neoplasm of Ovary|Stage II Malignant Germ Cell Neoplasm of the Ovary|Stage II Malignant Germ Cell Tumor of Ovary|Stage II Malignant Germ Cell Tumor of the Ovary|Stage II Malignant Ovarian Germ Cell Neoplasm|Stage II Malignant Ovarian Germ Cell Tumor	Stage II ovarian germ cell tumor is growth involving one or both ovaries with pelvic extension.  Stage IIA: extension and/or metastases to the uterus and/or tubes.  Stage IIB: extension to other pelvic tissues.  Stage IIC: tumor either stage IIA or stage IIB, but with tumor on the surface of one or both ovaries; or with capsule(s) ruptured; or with ascites present containing malignant cells or with positive peritoneal washings.
C8085	Stage_III_Ovarian_Germ_Cell_Tumor	Malignant_Ovarian_Germ_Cell_Tumor	Stage III Ovarian Germ Cell Tumor|Stage III Malignant Germ Cell Neoplasm of Ovary|Stage III Malignant Germ Cell Neoplasm of the Ovary|Stage III Malignant Germ Cell Tumor of Ovary|Stage III Malignant Germ Cell Tumor of the Ovary|Stage III Malignant Ovarian Germ Cell Neoplasm|Stage III Malignant Ovarian Germ Cell Tumor	Stage IIIA: tumor grossly limited to the true pelvis with negative nodes but with histologically confirmed microscopic seeding of abdominal peritoneal surfaces.  Stage IIIB: tumor of one or both ovaries with histologically confirmed implants of abdominal peritoneal surfaces, none exceeding 2 cm in diameter; negative nodes.  Stage IIIC: abdominal implants greater than 2 cm in diameter and/or positive retroperitoneal or inguinal nodes.
C8086	Stage_IV_Ovarian_Germ_Cell_Tumor	Malignant_Ovarian_Germ_Cell_Tumor	Stage IV Ovarian Germ Cell Tumor|Stage IV Malignant Germ Cell Neoplasm of Ovary|Stage IV Malignant Germ Cell Neoplasm of the Ovary|Stage IV Malignant Germ Cell Tumor of Ovary|Stage IV Malignant Germ Cell Tumor of the Ovary|Stage IV Malignant Ovarian Germ Cell Neoplasm|Stage IV Malignant Ovarian Germ Cell Tumor	Stage IV ovarian germ cell tumor is growth involving one or both ovaries with distant metastasis. If pleural effusion is present, there must be positive cytologic test results to allot a case to stage IV. Parenchymal liver metastasis equals stage IV.
C8087	Recurrent_Ovarian_Germ_Cell_Tumor	Malignant_Ovarian_Germ_Cell_Tumor	Recurrent Ovarian Germ Cell Tumor|Recurrent Germ Cell Neoplasm of Ovary|Recurrent Germ Cell Neoplasm of the Ovary|Recurrent Germ Cell Tumor of Ovary|Recurrent Germ Cell Tumor of the Ovary|Recurrent Ovarian Germ Cell Neoplasm|Relapsed Germ Cell Neoplasm of Ovary|Relapsed Germ Cell Neoplasm of the Ovary|Relapsed Germ Cell Tumor of Ovary|Relapsed Germ Cell Tumor of the Ovary|Relapsed Ovarian Germ Cell Neoplasm|Relapsed Ovarian Germ Cell Tumor
C8088	Childhood_Fibrosarcoma	Childhood_Soft_Tissue_Sarcoma|Fibrosarcoma	Childhood Fibrosarcoma|Pediatric Fibrosarcoma
C8089	Childhood_Synovial_Sarcoma	Childhood_Soft_Tissue_Sarcoma|Synovial_Sarcoma	Childhood Synovial Sarcoma|Pediatric Synovial Sarcoma
C8090	Malignant_Childhood_Hemangiopericytoma	Malignant_Childhood_Neoplasm|Malignant_Hemangiopericytoma	Malignant Childhood Hemangiopericytoma|Childhood Malignant Hemangiopericytoma|Malignant Pediatric Hemangiopericytoma
C8091	Childhood_Liposarcoma	Liposarcoma	Childhood Liposarcoma|Pediatric Liposarcoma
C8092	Childhood_Alveolar_Soft_Part_Sarcoma	Alveolar_Soft_Part_Sarcoma|Childhood_Soft_Tissue_Sarcoma	Childhood Alveolar Soft Part Sarcoma|Childhood Alveolar Soft-Part Sarcoma|Pediatric Alveolar Soft Part Sarcoma
C8093	Childhood_Leiomyosarcoma	Childhood_Soft_Tissue_Sarcoma|Leiomyosarcoma	Childhood Leiomyosarcoma|Pediatric Leiomyosarcoma
C8094	Childhood_Malignant_Peripheral_Nerve_Sheath_Tumor	Malignant_Childhood_Neoplasm|Malignant_Peripheral_Nerve_Sheath_Tumor	Childhood Malignant Peripheral Nerve Sheath Tumor|Childhood MPNST|Childhood Malignant Neoplasm of Peripheral Nerve Sheath|Childhood Malignant Neoplasm of the Peripheral Nerve Sheath|Childhood Malignant Neurilemmoma|Childhood Malignant Peripheral Nerve Sheath Neoplasm|Childhood Malignant Schwannoma|Childhood Malignant Tumor of Peripheral Nerve Sheath|Childhood Malignant Tumor of the Peripheral Nerve Sheath|Pediatric MPNST|Pediatric Malignant Neoplasm of Peripheral Nerve Sheath|Pediatric Malignant Neoplasm of the Peripheral Nerve Sheath|Pediatric Malignant Neurilemmoma|Pediatric Malignant Peripheral Nerve Sheath Neoplasm|Pediatric Malignant Peripheral Nerve Sheath Tumor|Pediatric Malignant Schwannoma|Pediatric Malignant Tumor of Peripheral Nerve Sheath|Pediatric Malignant Tumor of the Peripheral Nerve Sheath
C8095	Childhood_Epithelioid_Sarcoma	Childhood_Soft_Tissue_Sarcoma|Epithelioid_Sarcoma	Childhood Epithelioid Sarcoma|Pediatric Epithelioid Sarcoma
C8097	Childhood_Malignant_Mesenchymoma	Malignant_Mesenchymoma	Childhood Malignant Mesenchymoma
C8098	Recurrent_Adult_Non-Hodgkin_s_Lymphoma	Adult_Non-Hodgkin_s_Lymphoma|Recurrent_Non-Hodgkin_s_Lymphoma	Recurrent Adult Non-Hodgkin's Lymphoma|Adult Recurrent Non-Hodgkin's Lymphoma|Adult Relapsed Non-Hodgkin's Lymphoma|Relapsed Adult Non-Hodgkin's Lymphoma
C8099	Squamous_Cell_Carcinoma_of_Unknown_Primary	Carcinoma_of_Unknown_Primary|Metastatic_Squamous_Cell_Carcinoma	Squamous Cell Carcinoma of Unknown Primary Origin|Squamous Cell Carcinoma of Unknown Primary
C8100	Undifferentiated_Carcinoma_of_Unknown_Primary	Carcinoma_of_Unknown_Primary|Undifferentiated_Carcinoma	Undifferentiated Carcinoma of Unknown Primary
C8101	Adult_Solid_Neoplasm	Solid_Neoplasm	Adult Solid Neoplasm|Adult Solid Tumor
C8102	Stage_I_Adult_Non-Hodgkin_s_Lymphoma	Adult_Non-Hodgkin_s_Lymphoma_Stage|Stage_I_Non-Hodgkin_s_Lymphoma	Stage I Adult Non-Hodgkin's Lymphoma
C8103	Stage_II_Adult_Non-Hodgkin_s_Lymphoma	Adult_Non-Hodgkin_s_Lymphoma_Stage|Stage_II_Non-Hodgkin_s_Lymphoma	Stage II Adult Non-Hodgkin's Lymphoma|Adult Non-Hodgkin's Lymphoma Stage II|Adult Non-Hodgkins Lymphoma Stage II|Adult NonHodgkin's Lymphoma Stage II|Adult NonHodgkins Lymphoma Stage II|Stage II Adult Non-Hodgkins Lymphoma|Stage II Adult NonHodgkin's Lymphoma|Stage II Adult NonHodgkins Lymphoma
C8104	Stage_III_Adult_Non-Hodgkin_s_Lymphoma	Adult_Non-Hodgkin_s_Lymphoma_Stage|Stage_III_Non-Hodgkin_s_Lymphoma	Stage III Adult Non-Hodgkin's Lymphoma|Adult Non-Hodgkin's Lymphoma Stage III|Adult Non-Hodgkins Lymphoma Stage III|Adult NonHodgkin's Lymphoma Stage III|Adult NonHodgkins Lymphoma Stage III|Stage III Adult Non-Hodgkins Lymphoma|Stage III Adult NonHodgkin's Lymphoma|Stage III Adult NonHodgkins Lymphoma
C8105	Stage_IV_Adult_Non-Hodgkin_s_Lymphoma	Adult_Non-Hodgkin_s_Lymphoma_Stage|Stage_IV_Non-Hodgkin_s_Lymphoma	Stage IV Adult Non-Hodgkin's Lymphoma|Adult Non-Hodgkin's Lymphoma Stage IV|Adult Non-Hodgkins Lymphoma Stage IV|Adult NonHodgkin's Lymphoma Stage IV|Adult NonHodgkins Lymphoma Stage IV|Metastatic Adult Non-Hodgkin's Lymphoma|Metastatic Adult Non-Hodgkins Lymphoma|Metastatic Adult NonHodgkin's Lymphoma|Metastatic Adult NonHodgkins Lymphoma|Stage IV Adult Non-Hodgkins Lymphoma|Stage IV Adult NonHodgkin's Lymphoma|Stage IV Adult NonHodgkins Lymphoma
C8106	Ovarian_Dysgerminoma	Dysgerminoma|Ovarian_Primitive_Germ_Cell_Tumor	Ovarian Dysgerminoma|Dysgerminoma of Ovary|Dysgerminoma of the Ovary|Germ Cell Dysgerminoma of Ovary|Germ Cell Dysgerminoma of the Ovary|Ovarian Germ Cell Dysgerminoma
C8107	Ovarian_Yolk_Sac_Tumor	Ovarian_Primitive_Germ_Cell_Tumor|Yolk_Sac_Tumor	Ovarian Yolk Sac Tumor|Endodermal Sinus Neoplasm of Ovary|Endodermal Sinus Neoplasm of the Ovary|Endodermal Sinus Tumor of Ovary|Endodermal Sinus Tumor of the Ovary|Germ Cell Endodermal Sinus Neoplasm of Ovary|Germ Cell Endodermal Sinus Neoplasm of the Ovary|Germ Cell Endodermal Sinus Tumor of Ovary|Germ Cell Endodermal Sinus Tumor of the Ovary|Ovarian Endodermal Sinus Neoplasm|Ovarian Endodermal Sinus Tumor|Ovarian Germ Cell Endodermal Sinus Neoplasm|Ovarian Germ Cell Endodermal Sinus Tumor|Ovarian Yolk Sac Neoplasm|Yolk Sac Neoplasm of Ovary|Yolk Sac Neoplasm of the Ovary|Yolk Sac Tumor of Ovary|Yolk Sac Tumor of the Ovary
C8108	Ovarian_Embryonal_Carcinoma	Embryonal_Carcinoma|Ovarian_Primitive_Germ_Cell_Tumor	Ovarian Embryonal Carcinoma|Embryonal Carcinoma of Ovary|Embryonal Carcinoma of the Ovary
C8109	Ovarian_Polyembryoma	Retired_Concepts	Ovarian Polyembryoma|Germ Cell Polyembryoma of Ovary|Germ Cell Polyembryoma of the Ovary|Ovarian Germ Cell Polyembryoma|Polyembryoma of Ovary|Polyembryoma of the Ovary
C8110	Ovarian_Teratoma	Ovarian_Germ_Cell_Tumor|Teratoma	Ovarian Teratoma|Germ Cell Teratoma of Ovary|Germ Cell Teratoma of the Ovary|Ovarian Germ Cell Teratoma|Teratoma of Ovary|Teratoma of the Ovary
C8111	Immature_Ovarian_Teratoma	Immature_Teratoma|Malignant_Ovarian_Germ_Cell_Tumor|Ovarian_Biphasic_or_Triphasic_Teratoma	Immature Ovarian Teratoma|Immature Germ Cell Teratoma of Ovary|Immature Germ Cell Teratoma of the Ovary|Immature Teratoma of Ovary|Immature Teratoma of the Ovary|Malignant Germ Cell Teratoma of Ovary|Malignant Germ Cell Teratoma of the Ovary|Malignant Ovarian Germ Cell Teratoma|Malignant Ovarian Teratoma|Malignant Teratoma of Ovary|Malignant Teratoma of the Ovary|Ovarian Germ Cell Immature Teratoma|Ovarian Immature Germ Cell Teratoma|Ovarian Immature Teratoma
C8112	Mature_Ovarian_Teratoma	Mature_Teratoma|Ovarian_Biphasic_or_Triphasic_Teratoma	Mature Ovarian Teratoma|Mature Teratoma of Ovary|Mature Teratoma of the Ovary
C8113	Ovarian_Monodermal_and_Highly_Specialized_Teratoma	Ovarian_Monodermal_Teratoma	Ovarian Monodermal and Highly Specialized Teratoma|Ovarian Germ Cell Monodermal and Highly Specialized Teratoma
C8114	Ovarian_Mixed_Germ_Cell_Tumor	Mixed_Germ_Cell_Neoplasm|Ovarian_Primitive_Germ_Cell_Tumor	Ovarian Mixed Germ Cell Tumor|Mixed Germ Cell Neoplasm of Ovary|Mixed Germ Cell Neoplasm of the Ovary|Mixed Germ Cell Tumor of Ovary|Mixed Germ Cell Tumor of the Ovary|Ovarian Mixed Germ Cell Neoplasm
C8115	Stage_II_Small_Lymphocytic_Lymphoma	Small_Lymphocytic_Lymphoma|Stage_II_B-Cell_Non-Hodgkin_s_Lymphoma	Stage II Small Lymphocytic Lymphoma|B-Cell Small Lymphocytic Lymphoma Stage II|Small Lymphocytic Lymphoma Stage II|Stage II B-Cell Small Lymphocytic Lymphoma	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C8116	Stage_II_Grade_1_Follicular_Lymphoma	Grade_1_Follicular_Lymphoma|Stage_II_Follicular_Lymphoma	Stage II Grade 1 Follicular Lymphoma|Follicular Small Cleaved Cell Lymphoma Stage II|Grade I Follicular Lymphoma Stage II|Grade I Follicular Small Cleaved Cell Lymphoma Stage II|Stage II Follicular Small Cleaved Cell Lymphoma|Stage II Grade I Follicular Lymphoma|Stage II Grade I Follicular Small Cleaved Cell Lymphoma
C8117	Stage_II_Grade_2_Follicular_Lymphoma	Grade_2_Follicular_Lymphoma|Stage_II_Follicular_Lymphoma	Stage II Grade 2 Follicular Lymphoma|Follicular Mixed Cell Lymphoma Stage II|Grade II Follicular Lymphoma Stage II|Grade II Follicular Mixed Cell Lymphoma Stage II|Stage II Follicular Mixed Cell Lymphoma|Stage II Grade II Follicular Lymphoma|Stage II Grade II Follicular Mixed Cell Lymphoma
C8118	Stage_II_Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma	Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma	Stage II Intermediate Grade Adult Non-Hodgkin's Lymphoma
C8119	Stage_II_Grade_3_Follicular_Lymphoma	Grade_3_Follicular_Lymphoma|Stage_II_Follicular_Lymphoma	Stage II Grade 3 Follicular Lymphoma|Follicular Large Cell Lymphoma Stage II|Follicular Lymphoma Grade III Stage II|Grade III Follicular Lymphoma Stage II|Grade III Stage II Follicular Large Cell Lymphoma|Grade III Stage II Follicular Lymphoma|Stage II Follicular Large Cell Lymphoma|Stage II Grade III Follicular Large Cell Lymphoma
C8120	Stage_II_Adult_Diffuse_Small_Cleaved_Cell_Lymphoma	Adult_Diffuse_Small_Cleaved_Cell_Lymphoma	Stage II Adult Diffuse Small Cleaved Cell Lymphoma|Adult Diffuse Small Cleaved Cell Lymphoma Stage II
C8121	Stage_II_Adult_Diffuse_Mixed_Cell_Lymphoma	Adult_Diffuse_Mixed_Cell_Lymphoma	Stage II Adult Diffuse Mixed Cell Lymphoma|Adult Diffuse Mixed Cell Lymphoma Stage II
C8122	Stage_II_Adult_Diffuse_Large_Cell_Lymphoma	Adult_Diffuse_Large_Cell_Lymphoma	Stage II Adult Diffuse Large Cell Lymphoma|Adult Diffuse Large Cell Lymphoma Stage II
C8123	Stage_II_High-Grade_Adult_Non-Hodgkin_s_Lymphoma	High-Grade_Adult_Non-Hodgkin_s_Lymphoma	Stage II High Grade Adult Non-Hodgkin's Lymphoma
C8124	Stage_II_Adult_Immunoblastic_Lymphoma	Adult_Immunoblastic_Lymphoma|Stage_II_Diffuse_Large_B-Cell_Lymphoma	Stage II Adult Immunoblastic Lymphoma|Adult Immunoblastic Large Cell Lymphoma Stage II|Stage II Adult Immunoblastic Large Cell Lymphoma
C8125	Stage_II_Adult_Lymphoblastic_Lymphoma	Adult_Lymphoblastic_Lymphoma	Stage II Adult Lymphoblastic Lymphoma|Adult Lymphoblastic Lymphoma Stage II|Adult Stage II Lymphoblastic Lymphoma
C8126	Stage_II_Adult_Burkitt_s_Lymphoma	Adult_Burkitt_s_Lymphoma|Stage_II_Burkitt_s_Lymphoma	Stage II Adult Burkitt's Lymphoma|Adult Diffuse Small Non-Cleaved Cell Lymphoma Stage II|Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma Stage II|Stage II Adult Burkitt Lymphoma|Stage II Adult Diffuse Small Non-Cleaved Cell Lymphoma|Stage II Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma
C8127	Stage_III_Low-Grade_Adult_Non-Hodgkin_s_Lymphoma	Low-Grade_Adult_Non-Hodgkin_s_Lymphoma	Stage III Low Grade Adult Non-Hodgkin's Lymphoma
C8128	Stage_III_Small_Lymphocytic_Lymphoma	Small_Lymphocytic_Lymphoma|Stage_III_B-Cell_Non-Hodgkin_s_Lymphoma	Stage III Small Lymphocytic Lymphoma|B-Cell Small Lymphocytic Lymphoma Stage III|Small Lymphocytic Lymphoma Stage III|Stage III B-Cell Small Lymphocytic Lymphoma	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C8129	Stage_III_Grade_1_Follicular_Lymphoma	Grade_1_Follicular_Lymphoma|Stage_III_Follicular_Lymphoma	Stage III Grade 1 Follicular Lymphoma|Follicular Small Cleaved Cell Lymphoma Stage III|Grade I Follicular Lymphoma Stage III|Grade I Follicular Small Cleaved Cell Lymphoma Stage III|Stage III Follicular Small Cleaved Cell Lymphoma|Stage III Grade I Follicular Lymphoma|Stage III Grade I Follicular Small Cleaved Cell Lymphoma
C8130	Stage_III_Grade_2_Follicular_Lymphoma	Grade_2_Follicular_Lymphoma|Stage_III_Follicular_Lymphoma	Stage III Grade 2 Follicular Lymphoma|Follicular Mixed Cell Lymphoma Stage III|Grade II Follicular Lymphoma Stage III|Grade II Follicular Mixed Cell Lymphoma Stage III|Stage III Follicular Mixed Cell Lymphoma|Stage III Grade II Follicular Lymphoma|Stage III Grade II Follicular Mixed Cell Lymphoma
C8131	Stage_III_Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma	Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma	Stage III Intermediate Grade Adult Non-Hodgkin's Lymphoma
C8132	Stage_III_Grade_3_Follicular_Lymphoma	Grade_3_Follicular_Lymphoma|Stage_III_Follicular_Lymphoma	Stage III Grade 3 Follicular Lymphoma|Follicular Large Cell Lymphoma Stage III|Follicular Lymphoma Grade III Stage III|Grade III Follicular Large Cell Lymphoma Stage III|Grade III Follicular Lymphoma Stage III|Stage III Follicular Large Cell Lymphoma|Stage III Grade III Follicular Large Cell Lymphoma
C8133	Stage_III_Adult_Diffuse_Small_Cleaved_Cell_Lymphoma	Adult_Diffuse_Small_Cleaved_Cell_Lymphoma	Stage III Adult Diffuse Small Cleaved Cell Lymphoma|Adult Diffuse Small Cleaved Cell Lymphoma Stage III
C8134	Stage_III_Adult_Diffuse_Mixed_Cell_Lymphoma	Adult_Diffuse_Mixed_Cell_Lymphoma	Stage III Adult Diffuse Mixed Cell Lymphoma|Adult Diffuse Mixed Cell Lymphoma Stage III
C8135	Stage_III_Adult_Diffuse_Large_Cell_Lymphoma	Adult_Diffuse_Large_Cell_Lymphoma	Stage III Adult Diffuse Large Cell Lymphoma|Adult Diffuse Large Cell Lymphoma Stage III
C8136	Stage_III_High-Grade_Adult_Non-Hodgkin_s_Lymphoma	High-Grade_Adult_Non-Hodgkin_s_Lymphoma	Stage III High Grade Adult Non-Hodgkin's Lymphoma
C8137	Stage_III_Adult_Immunoblastic_Lymphoma	Adult_Immunoblastic_Lymphoma|Stage_III_Diffuse_Large_B-Cell_Lymphoma	Stage III Adult Immunoblastic Lymphoma|Adult Immunoblastic Large Cell Lymphoma Stage III|Stage III Adult Immunoblastic Large Cell Lymphoma
C8138	Stage_III_Adult_Lymphoblastic_Lymphoma	Adult_Lymphoblastic_Lymphoma	Stage III Adult Lymphoblastic Lymphoma|Adult Lymphoblastic Lymphoma Stage III|Adult Stage III Lymphoblastic Lymphoma
C8139	Stage_III_Adult_Burkitt_s_Lymphoma	Adult_Burkitt_s_Lymphoma|Stage_III_Burkitt_s_Lymphoma	Stage III Adult Burkitt's Lymphoma|Adult Diffuse Small Non-Cleaved Cell Lymphoma Stage III|Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma Stage III|Stage III Adult Burkitt Lymphoma|Stage III Adult Diffuse Small Non-Cleaved Cell Lymphoma|Stage III Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma
C8140	Stage_IV_Low-Grade_Adult_Non-Hodgkin_s_Lymphoma	Low-Grade_Adult_Non-Hodgkin_s_Lymphoma	Stage IV Low Grade Adult Non-Hodgkin's Lymphoma
C8141	Stage_IV_Small_Lymphocytic_Lymphoma	Small_Lymphocytic_Lymphoma|Stage_IV_B-Cell_Non-Hodgkin_s_Lymphoma	Stage IV Small Lymphocytic Lymphoma|B-Cell Small Lymphocytic Lymphoma Stage IV|Metastatic Small Lymphocytic Lymphoma|Small Lymphocytic Lymphoma Stage IV|Stage IV B-Cell Small Lymphocytic Lymphoma	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8142	Stage_IV_Grade_1_Follicular_Lymphoma	Grade_1_Follicular_Lymphoma|Stage_IV_Follicular_Lymphoma	Stage IV Grade 1 Follicular Lymphoma|Follicular Small Cleaved Cell Lymphoma Stage IV|Grade I Follicular Lymphoma Stage IV|Grade I Follicular Small Cleaved Cell Lymphoma Stage IV|Grade I Stage IV Follicular Lymphoma|Grade I Stage IV Follicular Small Cleaved Cell Lymphoma|Metastatic Follicular Small Cleaved Cell Lymphoma|Metastatic Grade I Follicular Lymphoma|Metastatic Grade I Follicular Small Cleaved Cell Lymphoma|Stage IV Follicular Small Cleaved Cell Lymphoma
C8143	Stage_IV_Grade_2_Follicular_Lymphoma	Grade_2_Follicular_Lymphoma|Stage_IV_Follicular_Lymphoma	Stage IV Grade 2 Follicular Lymphoma|Follicular Mixed Cell Lymphoma Stage IV|Grade II Follicular Lymphoma Stage IV|Grade II Follicular Mixed Cell Lymphoma Stage IV|Metastatic Follicular Mixed Cell Lymphoma|Metastatic Grade II Follicular Lymphoma|Metastatic Grade II Follicular Mixed Cell Lymphoma|Stage IV Follicular Mixed Cell Lymphoma|Stage IV Grade II Follicular Lymphoma|Stage IV Grade II Follicular Mixed Cell Lymphoma
C8144	Stage_IV_Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma	Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma	Stage IV Intermediate Grade Adult Non-Hodgkin's Lymphoma
C8145	Stage_IV_Grade_3_Follicular_Lymphoma	Grade_3_Follicular_Lymphoma|Stage_IV_Follicular_Lymphoma	Stage IV Grade 3 Follicular Lymphoma|Follicular Large Cell Lymphoma Stage IV|Grade III Follicular Lymphoma Stage IV|Grade III Metastatic Follicular Large Cell Lymphoma|Grade III Stage IV Follicular Large Cell Lymphoma|Metastatic Follicular Large Cell Lymphoma|Metastatic Grade III Follicular Large Cell Lymphoma|Metastatic Grade III Follicular Lymphoma|Stage IV Follicular Large Cell Lymphoma|Stage IV Grade III Follicular Large Cell Lymphoma|Stage IV Grade III Follicular Lymphoma
C8146	Stage_IV_Adult_Diffuse_Small_Cleaved_Cell_Lymphoma	Adult_Diffuse_Small_Cleaved_Cell_Lymphoma	Stage IV Adult Diffuse Small Cleaved Cell Lymphoma|Adult Diffuse Small Cleaved Cell Lymphoma Stage IV|Metastatic Adult Diffuse Small Cleaved Cell Lymphoma
C8147	Stage_IV_Adult_Diffuse_Mixed_Cell_Lymphoma	Adult_Diffuse_Mixed_Cell_Lymphoma	Stage IV Adult Diffuse Mixed Cell Lymphoma|Adult Diffuse Mixed Cell Lymphoma Stage IV|Metastatic Adult Diffuse Mixed Cell Lymphoma
C8148	Stage_IV_Adult_Diffuse_Large_Cell_Lymphoma	Adult_Diffuse_Large_Cell_Lymphoma	Stage IV Adult Diffuse Large Cell Lymphoma|Adult Diffuse Large Cell Lymphoma Stage IV|Metastatic Adult Diffuse Large Cell Lymphoma
C8149	Stage_IV_High-Grade_Adult_Non-Hodgkin_s_Lymphoma	High-Grade_Adult_Non-Hodgkin_s_Lymphoma	Stage IV High Grade Adult Non-Hodgkin's Lymphoma
C8150	Stage_IV_Adult_Immunoblastic_Lymphoma	Adult_Immunoblastic_Lymphoma|Stage_IV_Diffuse_Large_B-Cell_Lymphoma	Stage IV Adult Immunoblastic Lymphoma|Adult Immunoblastic Large Cell Lymphoma Stage IV|Metastatic Adult Immunoblastic Large Cell Lymphoma|Stage IV Adult Immunoblastic Large Cell Lymphoma
C8151	Stage_IV_Adult_Lymphoblastic_Lymphoma	Adult_Lymphoblastic_Lymphoma	Stage IV Adult Lymphoblastic Lymphoma|Adult Lymphoblastic Lymphoma Stage IV|Adult Stage IV Lymphoblastic Lymphoma|Metastatic Adult Lymphoblastic Lymphoma
C8152	Stage_IV_Adult_Burkitt_s_Lymphoma	Adult_Burkitt_s_Lymphoma|Stage_IV_Burkitt_s_Lymphoma	Stage IV Adult Burkitt's Lymphoma|Adult Diffuse Small Non-Cleaved Cell Lymphoma Stage IV|Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma Stage IV|Metastatic Adult Diffuse Small Non-Cleaved Cell Lymphoma|Metastatic Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma|Stage IV Adult Burkitt Lymphoma|Stage IV Adult Diffuse Small Non-Cleaved Cell Lymphoma|Stage IV Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma
C8153	Recurrent_Low-Grade_Adult_Non-Hodgkin_s_Lymphoma	Low-Grade_Adult_Non-Hodgkin_s_Lymphoma	Recurrent Low Grade Adult Non-Hodgkin's Lymphoma
C8154	Recurrent_Small_Lymphocytic_Lymphoma	Recurrent_B-Cell_Non-Hodgkin_s_Lymphoma|Small_Lymphocytic_Lymphoma	Recurrent Small Lymphocytic Lymphoma|Recurrent B-Cell Small Lymphocytic Lymphoma|Relapsed B-Cell Small Lymphocytic Lymphoma|Relapsed Small Lymphocytic Lymphoma	The reemergence of B-cell small lymphocytic lymphoma after a period of remission
C8155	Recurrent_Grade_1_Follicular_Lymphoma	Grade_1_Follicular_Lymphoma|Recurrent_Follicular_Lymphoma	Recurrent Grade 1 Follicular Lymphoma|Recurrent Follicular Small Cleaved Cell Lymphoma|Recurrent Grade I Follicular Lymphoma|Recurrent Grade I Follicular Small Cleaved Cell Lymphoma|Relapsed Follicular Small Cleaved Cell Lymphoma|Relapsed Grade I Follicular Lymphoma|Relapsed Grade I Follicular Small Cleaved Cell Lymphoma
C8156	Recurrent_Grade_2_Follicular_Lymphoma	Grade_2_Follicular_Lymphoma|Recurrent_Follicular_Lymphoma	Recurrent Grade 2 Follicular Lymphoma|Recurrent Follicular Mixed Cell Lymphoma|Recurrent Grade II Follicular Lymphoma|Recurrent Grade II Follicular Mixed Cell Lymphoma|Relapsed Follicular Mixed Cell Lymphoma|Relapsed Grade II Follicular Lymphoma|Relapsed Grade II Follicular Mixed Cell Lymphoma
C8157	Recurrent_Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma	Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma	Recurrent Intermediate Grade Adult Non-Hodgkin's Lymphoma
C8158	Recurrent_Grade_3_Follicular_Lymphoma	Grade_3_Follicular_Lymphoma|Recurrent_Follicular_Lymphoma	Recurrent Grade 3 Follicular Lymphoma|Recurrent Follicular Large Cell Lymphoma|Recurrent Grade III Follicular Large Cell Lymphoma|Recurrent Grade III Follicular Lymphoma|Relapsed Follicular Large Cell Lymphoma|Relapsed Grade III Follicular Large Cell Lymphoma|Relapsed Grade III Follicular Lymphoma
C8159	Recurrent_Adult_Burkitt_s_Lymphoma	Adult_Burkitt_s_Lymphoma|Recurrent_Adult_Non-Hodgkin_s_Lymphoma|Recurrent_Burkitt_s_Lymphoma	Recurrent Adult Burkitt's Lymphoma|Recurrent Adult Burkitt Lymphoma|Recurrent Adult Diffuse Small Non-Cleaved Cell Lymphoma|Recurrent Adult Small Non-Cleaved Cell/Burkitt's Lymphoma|Relapsed Adult Small Non-Cleaved Cell/Burkitt's Lymphoma
C8160	Recurrent_Adult_Diffuse_Mixed_Cell_Lymphoma	Adult_Diffuse_Mixed_Cell_Lymphoma	Recurrent Adult Diffuse Mixed Cell Lymphoma|Relapsed Adult Diffuse Mixed Cell Lymphoma
C8161	Recurrent_Adult_Diffuse_Large_Cell_Lymphoma	Adult_Diffuse_Large_Cell_Lymphoma	Recurrent Adult Diffuse Large Cell Lymphoma|Relapsed Adult Diffuse Large Cell Lymphoma
C8162	Recurrent_High-Grade_Adult_Non-Hodgkin_s_Lymphoma	High-Grade_Adult_Non-Hodgkin_s_Lymphoma	Recurrent High Grade Adult Non-Hodgkin's Lymphoma
C8163	Recurrent_Adult_Immunoblastic_Lymphoma	Adult_Immunoblastic_Lymphoma|Recurrent_Adult_Non-Hodgkin_s_Lymphoma|Recurrent_Diffuse_Large_B-Cell_Lymphoma	Recurrent Adult Immunoblastic Lymphoma|Recurrent Adult Immunoblastic Large Cell Lymphoma|Relapsed Adult Immunoblastic Large Cell Lymphoma|Relapsed Adult Immunoblastic Lymphoma
C8164	Recurrent_Adult_Lymphoblastic_Lymphoma	Adult_Lymphoblastic_Lymphoma|Recurrent_Adult_Non-Hodgkin_s_Lymphoma	Recurrent Adult Lymphoblastic Lymphoma|Adult Recurrent Lymphoblastic Lymphoma
C8166	Adult_Non-Hodgkin_s_Lymphoma_Grade	Lymphoma_by_Working_Formulation_Antiquated	Adult Non-Hodgkin's Lymphoma Grade|Adult Non-Hodgkins Lymphoma Grade|Adult NonHodgkin's Lymphoma Grade|Adult NonHodgkins Lymphoma Grade|Grade Adult Non-Hodgkins Lymphoma|Grade Adult NonHodgkin's Lymphoma|Grade Adult NonHodgkins Lymphoma
C8167	Localized_Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter	Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter	Localized Urothelial Carcinoma of the Renal Pelvis and Ureter|Localized Transitional Cell Cancer of Renal Pelvis and Ureter|Localized Transitional Cell Cancer of the Renal Pelvis and Ureter|Localized Transitional Cell Carcinoma of Renal Pelvis and Ureter
C8168	Regional_Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter	Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter	Regional Urothelial Carcinoma of the Renal Pelvis and Ureter|Regional Transitional Cell Cancer of Renal Pelvis and Ureter|Regional Transitional Cell Cancer of the Renal Pelvis and Ureter|Regional Transitional Cell Carcinoma of Renal Pelvis and Ureter
C8169	Anterior_Tongue_Squamous_Cell_Carcinoma	Anterior_Tongue_Carcinoma|Tongue_Squamous_Cell_Carcinoma	Anterior Tongue Squamous Cell Carcinoma|Anterior Tongue SCC|Squamous Cell Carcinoma of Anterior Tongue|Squamous Cell Carcinoma of the Anterior Tongue
C8170	Hard_Palate_Squamous_Cell_Carcinoma	Hard_Palate_Carcinoma|Palate_Squamous_Cell_Carcinoma	Hard Palate Squamous Cell Carcinoma|Hard Palate SCC|SCC of Hard Palate|SCC of the Hard Palate|Squamous Cell Carcinoma of Hard Palate|Squamous Cell Carcinoma of the Hard Palate
C8171	Lower_Gingival_Squamous_Cell_Carcinoma	Lower_Gingival_Carcinoma|Oral_Cavity_Squamous_Cell_Carcinoma	Lower Gingival Squamous Cell Carcinoma|Lower Gingival SCC|Lower Gum SCC|Lower Gum Squamous Cell Carcinoma|SCC of Lower Gingiva|SCC of Lower Gum|SCC of the Lower Gingiva|SCC of the Lower Gum|Squamous Cell Carcinoma of Lower Gingiva|Squamous Cell Carcinoma of Lower Gum|Squamous Cell Carcinoma of the Lower Gingiva|Squamous Cell Carcinoma of the Lower Gum
C8172	Retromolar_Trigone_Squamous_Cell_Carcinoma	Gingival_Carcinoma|Oral_Cavity_Squamous_Cell_Carcinoma	Retromolar Trigone Squamous Cell Carcinoma|Squamous Cell Carcinoma of Retromolar Trigone|Squamous Cell Carcinoma of the Retromolar Trigone
C8173	Upper_Gingival_Squamous_Cell_Carcinoma	Oral_Cavity_Squamous_Cell_Carcinoma|Upper_Gingival_Carcinoma	Upper Gingival Squamous Cell Carcinoma|SCC of Upper Gingiva|SCC of Upper Gum|SCC of the Upper Gingiva|SCC of the Upper Gum|Squamous Cell Carcinoma of Upper Gingiva|Squamous Cell Carcinoma of Upper Gum|Squamous Cell Carcinoma of the Upper Gingiva|Squamous Cell Carcinoma of the Upper Gum|Upper Gingival SCC|Upper Gum SCC|Upper Gum Squamous Cell Carcinoma
C8174	Oral_Cavity_Verrucous_Carcinoma	Oral_Cavity_Squamous_Cell_Carcinoma|Verrucous_Carcinoma	Oral Cavity Verrucous Carcinoma|Mouth Verrucous Carcinoma|Verrucous Carcinoma of Mouth|Verrucous Carcinoma of Oral Cavity|Verrucous Carcinoma of the Mouth|Verrucous Carcinoma of the Oral Cavity
C8175	Buccal_Mucosa_Verrucous_Carcinoma	Buccal_Mucosa_Squamous_Cell_Carcinoma|Oral_Cavity_Verrucous_Carcinoma	Buccal Mucosa Verrucous Carcinoma|Verrucous Carcinoma of Buccal Mucosa|Verrucous Carcinoma of the Buccal Mucosa
C8176	Lower_Gingival_Verrucous_Carcinoma	Lower_Gingival_Squamous_Cell_Carcinoma|Oral_Cavity_Verrucous_Carcinoma	Lower Gingival Verrucous Carcinoma|Lower Gum Verrucous Carcinoma|Verrucous Carcinoma of Lower Gingiva|Verrucous Carcinoma of Lower Gum|Verrucous Carcinoma of the Lower Gingiva|Verrucous Carcinoma of the Lower Gum
C8177	Oral_Cavity_Mucoepidermoid_Carcinoma	Mucoepidermoid_Carcinoma|Oral_Cavity_Carcinoma	Oral Cavity Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Oral Cavity|Mucoepidermoid Carcinoma of the Oral Cavity
C8178	Floor_of_Mouth_Mucoepidermoid_Carcinoma	Floor_of_the_Mouth_Carcinoma|Oral_Cavity_Mucoepidermoid_Carcinoma	Floor of Mouth Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Floor of Mouth|Mucoepidermoid Carcinoma of the Floor of Mouth
C8179	Oral_Cavity_Adenoid_Cystic_Carcinoma	Adenoid_Cystic_Carcinoma|Oral_Cavity_Carcinoma	Oral Cavity Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Mouth|Adenoid Cystic Carcinoma of Oral Cavity|Adenoid Cystic Carcinoma of the Mouth|Adenoid Cystic Carcinoma of the Oral Cavity|Mouth Adenoid Cystic Carcinoma
C8180	Floor_of_Mouth_Adenoid_Cystic_Carcinoma	Floor_of_the_Mouth_Carcinoma|Oral_Cavity_Adenoid_Cystic_Carcinoma	Floor of Mouth Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Floor of Mouth|Adenoid Cystic Carcinoma of the Floor of Mouth
C8181	Oropharyngeal_Squamous_Cell_Carcinoma	Head_and_Neck_Squamous_Cell_Carcinoma|Oropharyngeal_Carcinoma	Oropharyngeal Squamous Cell Carcinoma|Epidermoid Carcinoma of Oropharynx|Epidermoid Carcinoma of the Oropharynx|Oropharyngeal Epidermoid Carcinoma|Squamous Cell Carcinoma of Oropharynx|Squamous Cell Carcinoma of the Oropharynx
C8182	Posterior_Tongue_Squamous_Cell_Carcinoma	Posterior_Tongue_Carcinoma|Tongue_Squamous_Cell_Carcinoma	Posterior Tongue Squamous Cell Carcinoma|Posterior Tongue SCC|SCC of Posterior Tongue|SCC of the Posterior Tongue|Squamous Cell Carcinoma of Posterior Tongue|Squamous Cell Carcinoma of the Posterior Tongue
C8183	Tonsillar_Squamous_Cell_Carcinoma	Oropharyngeal_Squamous_Cell_Carcinoma|Tonsillar_Carcinoma	Tonsillar Squamous Cell Carcinoma|SCC of Tonsil|SCC of the Tonsil|Squamous Cell Carcinoma of Tonsil|Squamous Cell Carcinoma of the Tonsil|Tonsil SCC|Tonsil Squamous Cell Carcinoma|Tonsillar SCC
C8184	Tonsillar_Undifferentiated_Carcinoma	Nasopharyngeal_Type_Undifferentiated_Carcinoma|Tonsillar_Carcinoma	Tonsillar Undifferentiated Carcinoma|Tonsillar Lymphoepithelioma
C8185	Postcricoid_Squamous_Cell_Carcinoma	Hypopharyngeal_Squamous_Cell_Carcinoma|Postcricoid_Carcinoma	Postcricoid Squamous Cell Carcinoma|Epidermoid Carcinoma of Postcricoid Area|Epidermoid Carcinoma of the Postcricoid Area|Postcricoid Epidermoid Carcinoma|Squamous Cell Carcinoma of Postcricoid Area|Squamous Cell Carcinoma of the Postcricoid Area
C8186	Glottis_Squamous_Cell_Carcinoma	Glottis_Carcinoma|Laryngeal_Squamous_Cell_Carcinoma	Glottis Squamous Cell Carcinoma|Epidermoid Carcinoma of Glottis|Epidermoid Carcinoma of the Glottis|Glottic Epidermoid Carcinoma|Glottic Squamous Cell Carcinoma|Glottis Epidermoid Carcinoma|Squamous Cell Carcinoma of Glottis|Squamous Cell Carcinoma of the Glottis
C8187	Subglottic_Squamous_Cell_Carcinoma	Laryngeal_Squamous_Cell_Carcinoma|Subglottic_Carcinoma	Subglottic Squamous Cell Carcinoma|Epidermoid Carcinoma of Subglottis|Epidermoid Carcinoma of the Subglottis|Squamous Cell Carcinoma of Subglottis|Squamous Cell Carcinoma of the Subglottis|Subglottic Epidermoid Carcinoma|Subglottis Epidermoid Carcinoma|Subglottis Squamous Cell Carcinoma
C8188	Laryngeal_Verrucous_Carcinoma	Laryngeal_Squamous_Cell_Carcinoma|Verrucous_Carcinoma	Laryngeal Verrucous Carcinoma|Larynx Verrucous Carcinoma|Verrucous Carcinoma of Larynx|Verrucous Carcinoma of the Larynx
C8189	Glottis_Verrucous_Carcinoma	Glottis_Squamous_Cell_Carcinoma|Laryngeal_Verrucous_Carcinoma	Glottis Verrucous Carcinoma|Glottic Verrucous Carcinoma|Verrucous Carcinoma of Glottis|Verrucous Carcinoma of the Glottis
C8190	Subglottic_Verrucous_Carcinoma	Laryngeal_Verrucous_Carcinoma|Subglottic_Squamous_Cell_Carcinoma	Subglottic Verrucous Carcinoma|Subglottis Verrucous Carcinoma|Verrucous Carcinoma of Subglottis|Verrucous Carcinoma of the Subglottis
C8191	Supraglottic_Verrucous_Carcinoma	Laryngeal_Verrucous_Carcinoma|Supraglottic_Squamous_Cell_Carcinoma	Supraglottic Verrucous Carcinoma|Supraglottis Verrucous Carcinoma|Verrucous Carcinoma of Supraglottis|Verrucous Carcinoma of the Supraglottis
C8192	Nasal_Cavity_Squamous_Cell_Carcinoma	Head_and_Neck_Squamous_Cell_Carcinoma|Nasal_Cavity_Carcinoma	Nasal Cavity Squamous Cell Carcinoma|Squamous Cell Carcinoma of Nasal Cavity|Squamous Cell Carcinoma of the Nasal Cavity
C8193	Paranasal_Sinus_Squamous_Cell_Carcinoma	Head_and_Neck_Squamous_Cell_Carcinoma|Paranasal_Sinus_Carcinoma	Paranasal Sinus Squamous Cell Carcinoma|Epidermoid Carcinoma of Paranasal Sinus|Epidermoid Carcinoma of the Paranasal Sinus|Paranasal Sinus Epidermoid Carcinoma|Squamous Cell Carcinoma of Paranasal Sinus|Squamous Cell Carcinoma of the Paranasal Sinus
C8194	Nasal_Cavity_Inverted_Papilloma	Benign_Nasal_Cavity_Neoplasm|Inverted_Papilloma	Nasal Cavity Inverted Papilloma|Inverting Papilloma of Nasal Cavity|Inverting Papilloma of the Nasal Cavity
C8195	Paranasal_Sinus_Inverted_Papilloma	Benign_Paranasal_Sinus_Neoplasm|Inverted_Papilloma	Paranasal Sinus Inverted Papilloma|Accessory Sinus Inverted Papilloma|Accessory Sinus Inverting Papilloma|Inverted Papilloma of Accessory Sinus|Inverted Papilloma of Paranasal Sinus|Inverted Papilloma of the Accessory Sinus|Inverted Papilloma of the Paranasal Sinus|Inverting Papilloma of Accessory Sinus|Inverting Papilloma of Paranasal Sinus|Inverting Papilloma of the Accessory Sinus|Inverting Papilloma of the Paranasal Sinus|Paranasal Sinus Inverting Papilloma
C8196	Nasal_Cavity_Lethal_Midline_Granuloma	Granuloma_by_Site	Nasal Cavity Lethal Midline Granuloma|Midfacial Necrotising Lesion|Midline Lethal Granuloma of Nasal Cavity|Midline Lethal Granuloma of the Nasal Cavity
C8197	Stage_I_Lip_Basal_Cell_Carcinoma	Lip_Basal_Cell_Carcinoma	Stage I Lip Basal Cell Carcinoma|Stage I Basal Cell Carcinoma of Lip|Stage I Basal Cell Carcinoma of the Lip
C8198	Stage_I_Oral_Cavity_Verrucous_Carcinoma	Oral_Cavity_Verrucous_Carcinoma|Stage_I_Oral_Cavity_Squamous_Cell_Carcinoma	Stage I Oral Cavity Verrucous Carcinoma|Stage I Mouth Verrucous Carcinoma|Stage I Verrucous Carcinoma of Mouth|Stage I Verrucous Carcinoma of Oral Cavity|Stage I Verrucous Carcinoma of the Mouth|Stage I Verrucous Carcinoma of the Oral Cavity
C8199	Stage_I_Oral_Cavity_Mucoepidermoid_Carcinoma	Oral_Cavity_Mucoepidermoid_Carcinoma|Stage_I_Oral_Cavity_Carcinoma	Stage I Oral Cavity Mucoepidermoid Carcinoma|Stage I Mouth Mucoepidermoid Carcinoma|Stage I Mucoepidermoid Carcinoma of Mouth|Stage I Mucoepidermoid Carcinoma of Oral Cavity|Stage I Mucoepidermoid Carcinoma of the Mouth|Stage I Mucoepidermoid Carcinoma of the Oral Cavity
C8200	Stage_I_Oral_Cavity_Adenoid_Cystic_Carcinoma	Oral_Cavity_Adenoid_Cystic_Carcinoma|Stage_I_Oral_Cavity_Carcinoma	Stage I Oral Cavity Adenoid Cystic Carcinoma|Stage I Adenoid Cystic Carcinoma of Mouth|Stage I Adenoid Cystic Carcinoma of Oral Cavity|Stage I Adenoid Cystic Carcinoma of the Mouth|Stage I Adenoid Cystic Carcinoma of the Oral Cavity|Stage I Mouth Adenoid Cystic Carcinoma
C8201	Stage_II_Lip_Basal_Cell_Carcinoma	Lip_Basal_Cell_Carcinoma	Stage II Lip Basal Cell Carcinoma|Stage II Basal Cell Carcinoma of Lip|Stage II Basal Cell Carcinoma of the Lip
C8202	Stage_II_Oral_Cavity_Verrucous_Carcinoma	Oral_Cavity_Verrucous_Carcinoma|Stage_II_Oral_Cavity_Squamous_Cell_Carcinoma	Stage II Oral Cavity Verrucous Carcinoma|Stage II Mouth Verrucous Carcinoma|Stage II Verrucous Carcinoma of Mouth|Stage II Verrucous Carcinoma of Oral Cavity|Stage II Verrucous Carcinoma of the Mouth|Stage II Verrucous Carcinoma of the Oral Cavity
C8203	Stage_II_Oral_Cavity_Mucoepidermoid_Carcinoma	Oral_Cavity_Mucoepidermoid_Carcinoma|Stage_II_Oral_Cavity_Carcinoma	Stage II Oral Cavity Mucoepidermoid Carcinoma|Stage II Mouth Mucoepidermoid Carcinoma|Stage II Mucoepidermoid Carcinoma of Mouth|Stage II Mucoepidermoid Carcinoma of Oral Cavity|Stage II Mucoepidermoid Carcinoma of the Mouth|Stage II Mucoepidermoid Carcinoma of the Oral Cavity
C8204	Stage_II_Oral_Cavity_Adenoid_Cystic_Carcinoma	Oral_Cavity_Adenoid_Cystic_Carcinoma|Stage_II_Oral_Cavity_Carcinoma	Stage II Oral Cavity Adenoid Cystic Carcinoma|Stage II Adenoid Cystic Carcinoma of Mouth|Stage II Adenoid Cystic Carcinoma of Oral Cavity|Stage II Adenoid Cystic Carcinoma of the Mouth|Stage II Adenoid Cystic Carcinoma of the Oral Cavity|Stage II Mouth Adenoid Cystic Carcinoma
C8205	Stage_III_Lip_Basal_Cell_Carcinoma	Lip_Basal_Cell_Carcinoma	Stage III Lip Basal Cell Carcinoma|Stage III Basal Cell Carcinoma of Lip|Stage III Basal Cell Carcinoma of the Lip
C8206	Stage_III_Oral_Cavity_Verrucous_Carcinoma	Oral_Cavity_Verrucous_Carcinoma|Stage_III_Oral_Cavity_Squamous_Cell_Carcinoma	Stage III Oral Cavity Verrucous Carcinoma|Stage III Mouth Verrucous Carcinoma|Stage III Verrucous Carcinoma of Mouth|Stage III Verrucous Carcinoma of Oral Cavity|Stage III Verrucous Carcinoma of the Mouth|Stage III Verrucous Carcinoma of the Oral Cavity
C8207	Stage_III_Oral_Cavity_Mucoepidermoid_Carcinoma	Oral_Cavity_Mucoepidermoid_Carcinoma|Stage_III_Oral_Cavity_Carcinoma	Stage III Oral Cavity Mucoepidermoid Carcinoma|Stage III Mouth Mucoepidermoid Carcinoma|Stage III Mucoepidermoid Carcinoma of Mouth|Stage III Mucoepidermoid Carcinoma of Oral Cavity|Stage III Mucoepidermoid Carcinoma of the Mouth|Stage III Mucoepidermoid Carcinoma of the Oral Cavity
C8208	Stage_III_Oral_Cavity_Adenoid_Cystic_Carcinoma	Oral_Cavity_Adenoid_Cystic_Carcinoma|Stage_III_Oral_Cavity_Carcinoma	Stage III Oral Cavity Adenoid Cystic Carcinoma|Stage III Adenoid Cystic Carcinoma of Mouth|Stage III Adenoid Cystic Carcinoma of Oral Cavity|Stage III Adenoid Cystic Carcinoma of the Mouth|Stage III Adenoid Cystic Carcinoma of the Oral Cavity|Stage III Mouth Adenoid Cystic Carcinoma
C8209	Stage_IV_Lip_Basal_Cell_Carcinoma	Lip_Basal_Cell_Carcinoma	Stage IV Lip Basal Cell Carcinoma|Metastatic Basal Cell Carcinoma of Lip|Metastatic Basal Cell Carcinoma of the Lip|Metastatic Lip Basal Cell Carcinoma|Stage IV Basal Cell Carcinoma of Lip|Stage IV Basal Cell Carcinoma of the Lip
C8210	Stage_IV_Oral_Cavity_Verrucous_Carcinoma	Oral_Cavity_Verrucous_Carcinoma|Stage_IV_Oral_Cavity_Squamous_Cell_Carcinoma	Stage IV Oral Cavity Verrucous Carcinoma|Metastatic Mouth Verrucous Carcinoma|Metastatic Oral Cavity Verrucous Carcinoma|Metastatic Verrucous Carcinoma of Mouth|Metastatic Verrucous Carcinoma of Oral Cavity|Metastatic Verrucous Carcinoma of the Mouth|Metastatic Verrucous Carcinoma of the Oral Cavity|Stage IV Mouth Verrucous Carcinoma|Stage IV Verrucous Carcinoma of Mouth|Stage IV Verrucous Carcinoma of Oral Cavity|Stage IV Verrucous Carcinoma of the Mouth|Stage IV Verrucous Carcinoma of the Oral Cavity
C8211	Stage_IV_Oral_Cavity_Mucoepidermoid_Carcinoma	Oral_Cavity_Mucoepidermoid_Carcinoma|Stage_IV_Oral_Cavity_Carcinoma	Stage IV Oral Cavity Mucoepidermoid Carcinoma|Metastatic Mouth Mucoepidermoid Carcinoma|Metastatic Mucoepidermoid Carcinoma of Mouth|Metastatic Mucoepidermoid Carcinoma of Oral Cavity|Metastatic Mucoepidermoid Carcinoma of the Mouth|Metastatic Mucoepidermoid Carcinoma of the Oral Cavity|Metastatic Oral Cavity Mucoepidermoid Carcinoma|Stage IV Mouth Mucoepidermoid Carcinoma|Stage IV Mucoepidermoid Carcinoma of Mouth|Stage IV Mucoepidermoid Carcinoma of Oral Cavity|Stage IV Mucoepidermoid Carcinoma of the Mouth|Stage IV Mucoepidermoid Carcinoma of the Oral Cavity
C8212	Stage_IV_Oral_Cavity_Adenoid_Cystic_Carcinoma	Oral_Cavity_Adenoid_Cystic_Carcinoma|Stage_IV_Oral_Cavity_Carcinoma	Stage IV Oral Cavity Adenoid Cystic Carcinoma|Metastatic Adenoid Cystic Carcinoma of Mouth|Metastatic Adenoid Cystic Carcinoma of Oral Cavity|Metastatic Adenoid Cystic Carcinoma of the Mouth|Metastatic Adenoid Cystic Carcinoma of the Oral Cavity|Metastatic Mouth Adenoid Cystic Carcinoma|Metastatic Oral Cavity Adenoid Cystic Carcinoma|Stage IV Adenoid Cystic Carcinoma of Mouth|Stage IV Adenoid Cystic Carcinoma of Oral Cavity|Stage IV Adenoid Cystic Carcinoma of the Mouth|Stage IV Adenoid Cystic Carcinoma of the Oral Cavity|Stage IV Mouth Adenoid Cystic Carcinoma
C8213	Recurrent_Lip_Basal_Cell_Carcinoma	Lip_Basal_Cell_Carcinoma	Recurrent Lip Basal Cell Carcinoma|Recurrent Basal Cell Carcinoma of Lip|Recurrent Basal Cell Carcinoma of the Lip|Relapsed Basal Cell Carcinoma of Lip|Relapsed Basal Cell Carcinoma of the Lip|Relapsed Lip Basal Cell Carcinoma
C8214	Recurrent_Oral_Cavity_Verrucous_Carcinoma	Oral_Cavity_Verrucous_Carcinoma|Recurrent_Oral_Cavity_Squamous_Cell_Carcinoma	Recurrent Oral Cavity Verrucous Carcinoma|Recurrent Mouth Verrucous Carcinoma|Recurrent Verrucous Carcinoma of Mouth|Recurrent Verrucous Carcinoma of Oral Cavity|Recurrent Verrucous Carcinoma of the Mouth|Recurrent Verrucous Carcinoma of the Oral Cavity|Relapsed Mouth Verrucous Carcinoma|Relapsed Oral Cavity Verrucous Carcinoma|Relapsed Verrucous Carcinoma of Mouth|Relapsed Verrucous Carcinoma of Oral Cavity|Relapsed Verrucous Carcinoma of the Mouth|Relapsed Verrucous Carcinoma of the Oral Cavity
C8215	Recurrent_Oral_Cavity_Mucoepidermoid_Carcinoma	Oral_Cavity_Mucoepidermoid_Carcinoma|Recurrent_Oral_Cavity_Carcinoma	Recurrent Oral Cavity Mucoepidermoid Carcinoma|Recurrent Mouth Mucoepidermoid Carcinoma|Recurrent Mucoepidermoid Carcinoma of Mouth|Recurrent Mucoepidermoid Carcinoma of Oral Cavity|Recurrent Mucoepidermoid Carcinoma of the Mouth|Recurrent Mucoepidermoid Carcinoma of the Oral Cavity|Relapsed Mouth Mucoepidermoid Carcinoma|Relapsed Mucoepidermoid Carcinoma of Mouth|Relapsed Mucoepidermoid Carcinoma of Oral Cavity|Relapsed Mucoepidermoid Carcinoma of the Mouth|Relapsed Mucoepidermoid Carcinoma of the Oral Cavity|Relapsed Oral Cavity Mucoepidermoid Carcinoma
C8216	Recurrent_Oral_Cavity_Adenoid_Cystic_Carcinoma	Oral_Cavity_Adenoid_Cystic_Carcinoma|Recurrent_Oral_Cavity_Carcinoma	Recurrent Oral Cavity Adenoid Cystic Carcinoma|Recurrent Adenoid Cystic Carcinoma of Mouth|Recurrent Adenoid Cystic Carcinoma of Oral Cavity|Recurrent Adenoid Cystic Carcinoma of the Mouth|Recurrent Adenoid Cystic Carcinoma of the Oral Cavity|Recurrent Mouth Adenoid Cystic Carcinoma|Relapsed Adenoid Cystic Carcinoma of Mouth|Relapsed Adenoid Cystic Carcinoma of Oral Cavity|Relapsed Adenoid Cystic Carcinoma of the Mouth|Relapsed Adenoid Cystic Carcinoma of the Oral Cavity|Relapsed Mouth Adenoid Cystic Carcinoma|Relapsed Oral Cavity Adenoid Cystic Carcinoma
C8217	Stage_I_Oropharyngeal_Squamous_Cell_Carcinoma	Oropharyngeal_Squamous_Cell_Carcinoma|Stage_I_Oropharyngeal_Carcinoma	Stage I Oropharyngeal Squamous Cell Carcinoma|Stage I Epidermoid Carcinoma of Oropharynx|Stage I Epidermoid Carcinoma of the Oropharynx|Stage I Oropharyngeal Epidermoid Carcinoma|Stage I Oropharyngeal SCC|Stage I SCC of Oropharynx|Stage I SCC of the Oropharynx|Stage I Squamous Cell Carcinoma of Oropharynx|Stage I Squamous Cell Carcinoma of the Oropharynx
C8218	Stage_II_Oropharyngeal_Squamous_Cell_Carcinoma	Oropharyngeal_Squamous_Cell_Carcinoma|Stage_II_Oropharyngeal_Carcinoma	Stage II Oropharyngeal Squamous Cell Carcinoma|Stage II Epidermoid Carcinoma of Oropharynx|Stage II Epidermoid Carcinoma of the Oropharynx|Stage II Oropharyngeal Epidermoid Carcinoma|Stage II Oropharyngeal SCC|Stage II SCC of Oropharynx|Stage II SCC of the Oropharynx|Stage II Squamous Cell Carcinoma of Oropharynx|Stage II Squamous Cell Carcinoma of the Oropharynx
C8219	Stage_III_Oropharyngeal_Squamous_Cell_Carcinoma	Oropharyngeal_Squamous_Cell_Carcinoma|Stage_III_Oropharyngeal_Carcinoma	Stage III Oropharyngeal Squamous Cell Carcinoma|Stage III Epidermoid Carcinoma of Oropharynx|Stage III Epidermoid Carcinoma of the Oropharynx|Stage III Oropharyngeal Epidermoid Carcinoma|Stage III Oropharyngeal SCC|Stage III SCC of Oropharynx|Stage III SCC of the Oropharynx|Stage III Squamous Cell Carcinoma of Oropharynx|Stage III Squamous Cell Carcinoma of the Oropharynx
C8220	Stage_IV_Oropharyngeal_Squamous_Cell_Carcinoma	Oropharyngeal_Squamous_Cell_Carcinoma|Stage_IV_Oropharyngeal_Carcinoma	Stage IV Oropharyngeal Squamous Cell Carcinoma|Stage IV Epidermoid Carcinoma of Oropharynx|Stage IV Epidermoid Carcinoma of the Oropharynx|Stage IV Oropharyngeal Epidermoid Carcinoma|Stage IV Oropharyngeal SCC|Stage IV Oropharynx Epidermoid Carcinoma|Stage IV Oropharynx Squamous Cell Carcinoma|Stage IV SCC of Oropharynx|Stage IV SCC of the Oropharynx|Stage IV Squamous Cell Carcinoma of Oropharynx|Stage IV Squamous Cell Carcinoma of the Oropharynx
C8221	Recurrent_Oropharyngeal_Squamous_Cell_Carcinoma	Oropharyngeal_Squamous_Cell_Carcinoma|Recurrent_Oropharyngeal_Cancer	Recurrent Oropharyngeal Squamous Cell Carcinoma|Recurrent Epidermoid Carcinoma of Oropharynx|Recurrent Epidermoid Carcinoma of the Oropharynx|Recurrent Oropharyngeal Epidermoid Carcinoma|Recurrent Oropharyngeal SCC|Recurrent SCC of Oropharynx|Recurrent SCC of the Oropharynx|Recurrent Squamous Cell Carcinoma of Oropharynx|Recurrent Squamous Cell Carcinoma of the Oropharynx|Relapsed Epidermoid Carcinoma of Oropharynx|Relapsed Epidermoid Carcinoma of the Oropharynx|Relapsed Oropharyngeal Epidermoid Carcinoma|Relapsed Oropharyngeal SCC|Relapsed Oropharyngeal Squamous Cell Carcinoma|Relapsed SCC of Oropharynx|Relapsed SCC of the Oropharynx|Relapsed Squamous Cell Carcinoma of Oropharynx|Relapsed Squamous Cell Carcinoma of the Oropharynx
C8222	Stage_I_Nasopharyngeal_Squamous_Cell_Carcinoma	Nasopharyngeal_Squamous_Cell_Carcinoma|Stage_I_Nasopharyngeal_Carcinoma	Stage I Nasopharyngeal Squamous Cell Carcinoma|Stage I Epidermoid Carcinoma of Nasopharynx|Stage I Epidermoid Carcinoma of the Nasopharynx|Stage I Nasopharyngeal Epidermoid Carcinoma|Stage I Nasopharyngeal Keratinizing Squamous Cell Carcinoma|Stage I Squamous Cell Carcinoma of Nasopharynx|Stage I Squamous Cell Carcinoma of the Nasopharynx
C8223	Stage_I_Nasopharyngeal_Undifferentiated_Carcinoma	Nasopharyngeal_Undifferentiated_Carcinoma	Stage I Nasopharyngeal Undifferentiated Carcinoma|Nasopharyngeal Undifferentiated Carcinoma Stage I|Stage I Lymphoepithelioma of Nasopharynx|Stage I Lymphoepithelioma of the Nasopharynx|Stage I Nasopharyngeal Lymphoepithelioma
C8224	Stage_II_Nasopharyngeal_Squamous_Cell_Carcinoma	Nasopharyngeal_Squamous_Cell_Carcinoma|Stage_II_Nasopharyngeal_Carcinoma	Stage II Nasopharyngeal Squamous Cell Carcinoma|Stage II Epidermoid Carcinoma of Nasopharynx|Stage II Epidermoid Carcinoma of the Nasopharynx|Stage II Nasopharyngeal Epidermoid Carcinoma|Stage II Nasopharyngeal Keratinizing Squamous Cell Carcinoma|Stage II Squamous Cell Carcinoma of Nasopharynx|Stage II Squamous Cell Carcinoma of the Nasopharynx
C8225	Stage_II_Nasopharyngeal_Undifferentiated_Carcinoma	Nasopharyngeal_Undifferentiated_Carcinoma	Stage II Nasopharyngeal Undifferentiated Carcinoma|Nasopharyngeal Undifferentiated Carcinoma Stage II|Stage II Lymphoepithelioma of Nasopharynx|Stage II Lymphoepithelioma of the Nasopharynx|Stage II Nasopharyngeal Lymphoepithelioma
C8226	Stage_III_Nasopharyngeal_Squamous_Cell_Carcinoma	Nasopharyngeal_Squamous_Cell_Carcinoma|Stage_III_Nasopharyngeal_Carcinoma	Stage III Nasopharyngeal Squamous Cell Carcinoma|Stage III Epidermoid Carcinoma of Nasopharynx|Stage III Epidermoid Carcinoma of the Nasopharynx|Stage III Nasopharyngeal Epidermoid Carcinoma|Stage III Nasopharyngeal Keratinizing Squamous Cell Carcinoma|Stage III Squamous Cell Carcinoma of Nasopharynx|Stage III Squamous Cell Carcinoma of the Nasopharynx
C8227	Stage_III_Nasopharyngeal_Undifferentiated_Carcinoma	Nasopharyngeal_Undifferentiated_Carcinoma	Stage III Nasopharyngeal Undifferentiated Carcinoma|Nasopharyngeal Undifferentiated Carcinoma Stage III|Stage III Lymphoepithelioma of Nasopharynx|Stage III Lymphoepithelioma of the Nasopharynx|Stage III Nasopharyngeal Lymphoepithelioma
C8228	Stage_IV_Nasopharyngeal_Squamous_Cell_Carcinoma	Nasopharyngeal_Squamous_Cell_Carcinoma|Stage_IV_Nasopharyngeal_Carcinoma	Stage IV Nasopharyngeal Squamous Cell Carcinoma|Metastatic Epidermoid Carcinoma of Nasopharynx|Metastatic Epidermoid Carcinoma of the Nasopharynx|Metastatic Nasopharyngeal Epidermoid Carcinoma|Metastatic Nasopharyngeal Squamous Cell Carcinoma|Metastatic Squamous Cell Carcinoma of Nasopharynx|Metastatic Squamous Cell Carcinoma of the Nasopharynx|Stage IV Epidermoid Carcinoma of Nasopharynx|Stage IV Epidermoid Carcinoma of the Nasopharynx|Stage IV Nasopharyngeal Epidermoid Carcinoma|Stage IV Nasopharyngeal Keratinizing Squamous Cell Carcinoma|Stage IV Squamous Cell Carcinoma of Nasopharynx|Stage IV Squamous Cell Carcinoma of the Nasopharynx
C8229	Stage_IV_Nasopharyngeal_Undifferentiated_Carcinoma	Nasopharyngeal_Undifferentiated_Carcinoma	Stage IV Nasopharyngeal Undifferentiated Carcinoma|Metastatic Lymphoepithelioma of Nasopharynx|Metastatic Lymphoepithelioma of the Nasopharynx|Metastatic Nasopharyngeal Lymphoepithelioma|Nasopharyngeal Undifferentiated Carcinoma Stage IV|Stage IV Lymphoepithelioma of Nasopharynx|Stage IV Lymphoepithelioma of the Nasopharynx|Stage IV Nasopharyngeal Lymphoepithelioma
C8230	Recurrent_Nasopharyngeal_Squamous_Cell_Carcinoma	Nasopharyngeal_Squamous_Cell_Carcinoma|Recurrent_Nasopharyngeal_Carcinoma	Recurrent Nasopharyngeal Squamous Cell Carcinoma|Recurrent Epidermoid Carcinoma of Nasopharynx|Recurrent Epidermoid Carcinoma of the Nasopharynx|Recurrent Nasopharyngeal Epidermoid Carcinoma|Recurrent Nasopharyngeal Keratinizing Squamous Cell Carcinoma|Recurrent Squamous Cell Carcinoma of Nasopharynx|Recurrent Squamous Cell Carcinoma of the Nasopharynx|Relapsed Epidermoid Carcinoma of Nasopharynx|Relapsed Epidermoid Carcinoma of the Nasopharynx|Relapsed Nasopharyngeal Epidermoid Carcinoma|Relapsed Nasopharyngeal Squamous Cell Carcinoma|Relapsed Squamous Cell Carcinoma of Nasopharynx|Relapsed Squamous Cell Carcinoma of the Nasopharynx
C8231	Recurrent_Nasopharyngeal_Undifferentiated_Carcinoma	Nasopharyngeal_Undifferentiated_Carcinoma	Recurrent Nasopharyngeal Undifferentiated Carcinoma|Recurrent Lymphoepithelioma of Nasopharynx|Recurrent Lymphoepithelioma of the Nasopharynx|Recurrent Nasopharyngeal Lymphoepithelioma|Recurrent Undifferentiated Carcinoma of Nasopharynx|Recurrent Undifferentiated Carcinoma of the Nasopharynx|Relapsed Lymphoepithelioma of Nasopharynx|Relapsed Lymphoepithelioma of the Nasopharynx|Relapsed Nasopharyngeal Lymphoepithelioma|Relapsed Nasopharyngeal Undifferentiated Carcinoma|Relapsed Undifferentiated Carcinoma of Nasopharynx|Relapsed Undifferentiated Carcinoma of the Nasopharynx
C8232	Stage_I_Hypopharyngeal_Squamous_Cell_Carcinoma	Hypopharyngeal_Squamous_Cell_Carcinoma|Stage_I_Hypopharyngeal_Carcinoma	Stage I Hypopharyngeal Squamous Cell Carcinoma|Stage I Epidermoid Carcinoma of Hypopharynx|Stage I Epidermoid Carcinoma of the Hypopharynx|Stage I Hypopharyngeal Epidermoid Carcinoma|Stage I Squamous Cell Carcinoma of Hypopharynx|Stage I Squamous Cell Carcinoma of the Hypopharynx
C8233	Stage_II_Hypopharyngeal_Squamous_Cell_Carcinoma	Hypopharyngeal_Squamous_Cell_Carcinoma|Stage_II_Hypopharyngeal_Carcinoma	Stage II Hypopharyngeal Squamous Cell Carcinoma|Stage II Epidermoid Carcinoma of Hypopharynx|Stage II Epidermoid Carcinoma of the Hypopharynx|Stage II Hypopharyngeal Epidermoid Carcinoma|Stage II Squamous Cell Carcinoma of Hypopharynx|Stage II Squamous Cell Carcinoma of the Hypopharynx
C8234	Stage_III_Hypopharyngeal_Squamous_Cell_Carcinoma	Hypopharyngeal_Squamous_Cell_Carcinoma|Stage_III_Hypopharyngeal_Carcinoma	Stage III Hypopharyngeal Squamous Cell Carcinoma|Stage III Epidermoid Carcinoma of Hypopharynx|Stage III Epidermoid Carcinoma of the Hypopharynx|Stage III Hypopharyngeal Epidermoid Carcinoma|Stage III Squamous Cell Carcinoma of Hypopharynx|Stage III Squamous Cell Carcinoma of the Hypopharynx
C8235	Stage_IV_Hypopharyngeal_Squamous_Cell_Carcinoma	Hypopharyngeal_Squamous_Cell_Carcinoma|Stage_IV_Hypopharyngeal_Carcinoma	Stage IV Hypopharyngeal Squamous Cell Carcinoma|Metastatic Epidermoid Carcinoma of Hypopharynx|Metastatic Epidermoid Carcinoma of the Hypopharynx|Metastatic Hypopharyngeal Epidermoid Carcinoma|Metastatic Hypopharyngeal Squamous Cell Carcinoma|Metastatic Squamous Cell Carcinoma of Hypopharynx|Metastatic Squamous Cell Carcinoma of the Hypopharynx|Stage IV Epidermoid Carcinoma of Hypopharynx|Stage IV Epidermoid Carcinoma of the Hypopharynx|Stage IV Hypopharyngeal Epidermoid Carcinoma|Stage IV Squamous Cell Carcinoma of Hypopharynx|Stage IV Squamous Cell Carcinoma of the Hypopharynx
C8236	Recurrent_Hypopharyngeal_Squamous_Cell_Carcinoma	Hypopharyngeal_Squamous_Cell_Carcinoma|Recurrent_Hypopharyngeal_Carcinoma|Recurrent_Malignant_Hypopharyngeal_Neoplasm	Recurrent Hypopharyngeal Squamous Cell Carcinoma|Recurrent Epidermoid Carcinoma of Hypopharynx|Recurrent Epidermoid Carcinoma of the Hypopharynx|Recurrent Hypopharyngeal Epidermoid Carcinoma|Recurrent Squamous Cell Carcinoma of Hypopharynx|Recurrent Squamous Cell Carcinoma of the Hypopharynx|Relapsed Epidermoid Carcinoma of Hypopharynx|Relapsed Epidermoid Carcinoma of the Hypopharynx|Relapsed Hypopharyngeal Epidermoid Carcinoma|Relapsed Hypopharyngeal Squamous Cell Carcinoma|Relapsed Squamous Cell Carcinoma of Hypopharynx|Relapsed Squamous Cell Carcinoma of the Hypopharynx
C8237	Stage_I_Laryngeal_Squamous_Cell_Carcinoma	Laryngeal_Squamous_Cell_Carcinoma|Stage_I_Laryngeal_Cancer	Stage I Laryngeal Squamous Cell Carcinoma|Stage I Epidermoid Carcinoma of Larynx|Stage I Epidermoid Carcinoma of the Larynx|Stage I Laryngeal Epidermoid Carcinoma|Stage I Larynx Epidermoid Carcinoma|Stage I Larynx Squamous Cell Carcinoma|Stage I Squamous Cell Carcinoma of Larynx|Stage I Squamous Cell Carcinoma of the Larynx
C8238	Stage_I_Laryngeal_Verrucous_Carcinoma	Laryngeal_Verrucous_Carcinoma|Stage_I_Laryngeal_Squamous_Cell_Carcinoma	Stage I Laryngeal Verrucous Carcinoma|Stage I Larynx Verrucous Carcinoma|Stage I Verrucous Carcinoma of Larynx|Stage I Verrucous Carcinoma of the Larynx
C8239	Stage_II_Laryngeal_Squamous_Cell_Carcinoma	Laryngeal_Squamous_Cell_Carcinoma|Stage_II_Laryngeal_Cancer	Stage II Laryngeal Squamous Cell Carcinoma|Stage II Epidermoid Carcinoma of Larynx|Stage II Epidermoid Carcinoma of the Larynx|Stage II Laryngeal Epidermoid Carcinoma|Stage II Larynx Epidermoid Carcinoma|Stage II Larynx Squamous Cell Carcinoma|Stage II Squamous Cell Carcinoma of Larynx|Stage II Squamous Cell Carcinoma of the Larynx
C8240	Stage_II_Laryngeal_Verrucous_Carcinoma	Laryngeal_Verrucous_Carcinoma|Stage_II_Laryngeal_Squamous_Cell_Carcinoma	Stage II Laryngeal Verrucous Carcinoma|Stage II Larynx Verrucous Carcinoma|Stage II Verrucous Carcinoma of Larynx|Stage II Verrucous Carcinoma of the Larynx
C8241	Stage_III_Laryngeal_Squamous_Cell_Carcinoma	Laryngeal_Squamous_Cell_Carcinoma|Stage_III_Laryngeal_Cancer	Stage III Laryngeal Squamous Cell Carcinoma|Stage III Epidermoid Carcinoma of Larynx|Stage III Epidermoid Carcinoma of the Larynx|Stage III Laryngeal Epidermoid Carcinoma|Stage III Larynx Epidermoid Carcinoma|Stage III Larynx Squamous Cell Carcinoma|Stage III Squamous Cell Carcinoma of Larynx|Stage III Squamous Cell Carcinoma of the Larynx
C8242	Stage_III_Laryngeal_Verrucous_Carcinoma	Laryngeal_Verrucous_Carcinoma|Stage_III_Laryngeal_Squamous_Cell_Carcinoma	Stage III Laryngeal Verrucous Carcinoma|Stage III Larynx Verrucous Carcinoma|Stage III Verrucous Carcinoma of Larynx|Stage III Verrucous Carcinoma of the Larynx
C8243	Stage_IV_Laryngeal_Squamous_Cell_Carcinoma	Laryngeal_Squamous_Cell_Carcinoma|Stage_IV_Laryngeal_Cancer	Stage IV Laryngeal Squamous Cell Carcinoma|Metastatic Epidermoid Carcinoma of Larynx|Metastatic Epidermoid Carcinoma of the Larynx|Metastatic Laryngeal Epidermoid Carcinoma|Metastatic Laryngeal Squamous Cell Carcinoma|Metastatic Larynx Epidermoid Carcinoma|Metastatic Larynx Squamous Cell Carcinoma|Metastatic Squamous Cell Carcinoma of Larynx|Metastatic Squamous Cell Carcinoma of the Larynx|Stage IV Epidermoid Carcinoma of Larynx|Stage IV Epidermoid Carcinoma of the Larynx|Stage IV Laryngeal Epidermoid Carcinoma|Stage IV Larynx Epidermoid Carcinoma|Stage IV Larynx Squamous Cell Carcinoma|Stage IV Squamous Cell Carcinoma of Larynx|Stage IV Squamous Cell Carcinoma of the Larynx
C8244	Stage_IV_Laryngeal_Verrucous_Carcinoma	Laryngeal_Verrucous_Carcinoma|Stage_IV_Laryngeal_Squamous_Cell_Carcinoma	Stage IV Laryngeal Verrucous Carcinoma|Metastatic Laryngeal Verrucous Carcinoma|Metastatic Larynx Verrucous Carcinoma|Metastatic Verrucous Carcinoma of Larynx|Metastatic Verrucous Carcinoma of the Larynx|Stage IV Larynx Verrucous Carcinoma|Stage IV Verrucous Carcinoma of Larynx|Stage IV Verrucous Carcinoma of the Larynx
C8245	Recurrent_Laryngeal_Squamous_Cell_Carcinoma	Laryngeal_Squamous_Cell_Carcinoma|Recurrent_Laryngeal_Carcinoma	Recurrent Laryngeal Squamous Cell Carcinoma|Recurrent Epidermoid Carcinoma of Larynx|Recurrent Epidermoid Carcinoma of the Larynx|Recurrent Laryngeal Epidermoid Carcinoma|Recurrent Larynx Epidermoid Carcinoma|Recurrent Larynx Squamous Cell Carcinoma|Recurrent Squamous Cell Carcinoma of Larynx|Recurrent Squamous Cell Carcinoma of the Larynx|Relapsed Epidermoid Carcinoma of Larynx|Relapsed Epidermoid Carcinoma of the Larynx|Relapsed Laryngeal Epidermoid Carcinoma|Relapsed Laryngeal Squamous Cell Carcinoma|Relapsed Larynx Epidermoid Carcinoma|Relapsed Larynx Squamous Cell Carcinoma|Relapsed Squamous Cell Carcinoma of Larynx|Relapsed Squamous Cell Carcinoma of the Larynx
C8246	Recurrent_Laryngeal_Verrucous_Carcinoma	Laryngeal_Verrucous_Carcinoma|Recurrent_Laryngeal_Squamous_Cell_Carcinoma	Recurrent Laryngeal Verrucous Carcinoma|Recurrent Larynx Verrucous Carcinoma|Recurrent Verrucous Carcinoma of Larynx|Recurrent Verrucous Carcinoma of the Larynx|Relapsed Laryngeal Verrucous Carcinoma|Relapsed Larynx Verrucous Carcinoma|Relapsed Verrucous Carcinoma of Larynx|Relapsed Verrucous Carcinoma of the Larynx
C8247	Stage_I_Adult_T-Cell_Lymphoma_Leukemia	Adult_T-Cell_Lymphoma_Leukemia|Stage_I_Aggressive_Adult_Non-Hodgkin_s_Lymphoma|Stage_I_Mature_T-and_NK-Cell_Lymphoma	Stage I Adult T-Cell Lymphoma/Leukemia|Adult T-Cell Lymphoma/Leukemia Stage I|HTLV-1 Associated Adult T-Cell Lymphoma/Leukemia Stage I|Stage I HTLV-1 Associated Adult T-Cell Lymphoma/Leukemia	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C8248	Stage_II_Adult_T-Cell_Lymphoma_Leukemia	Adult_T-Cell_Lymphoma_Leukemia|Stage_II_Mature_T-and_NK-Cell_Lymphoma	Stage II Adult T-Cell Lymphoma/Leukemia|Adult T-Cell Lymphoma/Leukemia Stage II|HTLV-1 Associated Adult T-Cell Lymphoma/Leukemia Stage II|Stage II HTLV-1 Associated Adult T-Cell Lymphoma/Leukemia	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C8249	Stage_III_Adult_T-Cell_Lymphoma_Leukemia	Adult_T-Cell_Lymphoma_Leukemia|Stage_III_Aggressive_Adult_Non-Hodgkin_s_Lymphoma|Stage_III_Mature_T-and_NK-Cell_Lymphoma	Stage III Adult T-Cell Lymphoma/Leukemia|Adult T-Cell Lymphoma/Leukemia Stage III|HTLV-1 Associated Adult T-Cell Lymphoma/Leukemia Stage III|Stage III HTLV-1 Associated Adult T-Cell Lymphoma/Leukemia	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C8250	Stage_IV_Adult_T-Cell_Lymphoma_Leukemia	Adult_T-Cell_Lymphoma_Leukemia|Stage_IV_Aggressive_Adult_Non-Hodgkin_s_Lymphoma|Stage_IV_Mature_T-and_NK-Cell_Lymphoma	Stage IV Adult T-Cell Lymphoma/Leukemia|Adult T-Cell Lymphoma/Leukemia Stage IV|HTLV-1 Associated Adult T-Cell Lymphoma/Leukemia Stage IV|HTLV-I Associated Adult T-cell Leukemia/Lymphoma, Metastatic|Metastatic HTLV-1 Associated Adult T-Cell Lymphoma/Leukemia|Stage IV HTLV-1 Associated Adult T-Cell Lymphoma/Leukemia	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8251	Recurrent_Adult_T-Cell_Lymphoma_Leukemia	Adult_T-Cell_Lymphoma_Leukemia|Recurrent_Mature_T-and_NK-Cell_Non-Hodgkin_s_Lymphoma	Recurrent Adult T-Cell Lymphoma/Leukemia|Adult T-Cell Lymphoma/Leukemia Recurrent|HTLV-1 Associated Adult T-Cell Lymphoma/Leukemia Recurrent|HTLV-1 Associated Adult T-Cell Lymphoma/Leukemia Relapsed|Recurrent HTLV-1 Associated Adult T-Cell Lymphoma/Leukemia|Relapsed HTLV-1 Associated Adult T-Cell Lymphoma/Leukemia	The reemergence of adult T-cell lymphoma/leukemia after a period of remission
C8252	Therapy-Related_Acute_Myeloid_Leukemia	Secondary_Acute_Myeloid_Leukemia|Therapy-Related_Acute_Myeloid_Leukemia_and_Myelodysplastic_Syndrome	Therapy-Related Acute Myeloid Leukemia|Treatment Related AML|Treatment Related Acute Myelocytic Leukemia|Treatment Related Acute Myelogenous Leukemia|Treatment Related Acute Myeloid Leukemia|Treatment-Related AML|Treatment-Related Acute Myelocytic Leukemia|Treatment-Related Acute Myelogenous Leukemia|Treatment-related Acute Myeloid Leukemia	An acute myeloid leukemia arising as a result of the mutagenic effect of alkylating agents and/or ionizing radiation.  (WHO, 2001) -- 2003
C8253	de_novo_Myelodysplastic_Syndrome	Myelodysplastic_Syndrome	de novo Myelodysplastic Syndrome|Untreated Myelodysplastic Syndrome
C8254	Recurrent_Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter	Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter	Recurrent Urothelial Carcinoma of the Renal Pelvis and Ureter|Recurrent Transitional Cell Cancer of Renal Pelvis and Ureter|Recurrent Transitional Cell Cancer of the Renal Pelvis and Ureter|Recurrent Transitional Cell Carcinoma of Renal Pelvis and Ureter|Relapsed Transitional Cell Cancer of Renal Pelvis and Ureter|Relapsed Transitional Cell Cancer of the Renal Pelvis and Ureter|Relapsed Transitional Cell Carcinoma of Renal Pelvis and Ureter|Relapsed Transitional Cell Carcinoma of the Renal Pelvis and Ureter	Reemergence of transitional cell cancer of the renal pelvis and ureter after a period of remission.
C8255	Anal_Cloacogenic_Carcinoma	Anal_Squamous_Cell_Carcinoma	Anal Cloacogenic Carcinoma|Cloacogenic Anal Carcinoma|Cloacogenic Carcinoma|Cloacogenic Carcinoma of Anus|Cloacogenic Carcinoma of the Anus
C8256	Anal_Basaloid_Carcinoma	Anal_Squamous_Cell_Carcinoma	Anal Basaloid Carcinoma|Basaloid Carcinoma of Anus|Basaloid Carcinoma of the Anus
C8257	Adult_Anaplastic_Astrocytoma	Adult_Astrocytic_Tumor|Anaplastic_Astrocytoma	Adult Anaplastic Astrocytoma|Adult Grade III Astrocytoma|Adult Undifferentiated Astrocytoma|Anaplastic Astrocytoma of Adult|Anaplastic Astrocytoma of the Adult|Grade III Adult Astrocytic Neoplasm|Grade III Adult Astrocytic Tumor|Grade III Adult Astrocytoma|Undifferentiated Astrocytoma of Adult|Undifferentiated Astrocytoma of the Adult
C8258	Stage_I_Uterine_Sarcoma	Uterine_Corpus_Sarcoma	Stage I Uterine Sarcoma
C8259	Stage_II_Uterine_Sarcoma	Uterine_Corpus_Sarcoma	Stage II Uterine Sarcoma
C8260	Stage_III_Uterine_Sarcoma	Uterine_Corpus_Sarcoma	Stage III Uterine Sarcoma
C8261	Recurrent_Uterine_Sarcoma	Uterine_Corpus_Sarcoma	Recurrent Uterine Sarcoma|Recurrent Sarcoma of Uterus|Recurrent Sarcoma of the Uterus|Relapsed Sarcoma of Uterus|Relapsed Sarcoma of the Uterus|Relapsed Uterine Sarcoma
C8263	Adult_Acute_Differentiated_Monocytic_Leukemia	Adult_Acute_Monoblastic_Leukemia_and_Acute_Monocytic_Leukemia|Monocytic_Leukemia	Adult Acute Monocytic Leukemia|Adult Acute Differentiated Monocytic Leukemia (M5b)|M5b Adult Acute Differentiated Monocytic Leukemia|M5b Adult Acute Leukemia
C8264	Childhood_Meningioma	Childhood_Central_Nervous_System_Neoplasm|Meningioma	Childhood Meningioma|Pediatric Meningioma
C8265	Adult_Primary_Cholangiocarcinoma	Cholangiocarcinoma	Adult Primary Cholangiocarcinoma|Adult Primary Cholangiocellular Carcinoma
C8267	Ovarian_Sarcoma	Malignant_Ovarian_Neoplasm|Ovarian_Soft_Tissue_Neoplasm|Soft_Tissue_Sarcoma	Ovarian Sarcoma|Sarcoma of Ovary|Sarcoma of the Ovary
C8269	Adult_Anaplastic_Ependymoma	Anaplastic_Ependymoma	Adult Anaplastic Ependymoma|Adult Malignant Ependymoma|Malignant Adult Ependymoma
C8270	Adult_Anaplastic_Oligodendroglioma	Anaplastic_Oligodendroglioma	Adult Anaplastic Oligodendroglioma|Adult Undifferentiated Oligodendroglioma
C8271	Mixed_Astrocytoma-Ependymoma	Mixed_Glioma	Mixed Astrocytoma-Ependymoma	A tumor of mixed cell type with astrocytic components as well as ependymomas components.
C8272	Mixed_Astrocytoma-Ependymoma-Oligodendroglioma	Mixed_Glioma	Mixed Astrocytoma-Ependymoma-Oligodendroglioma
C8273	Adult_Pineal_Parenchymal_Cell_Neoplasm	Adult_Brain_Neoplasm|Pineal_Parenchymal_Cell_Neoplasm	Adult Pineal Parenchymal Cell Neoplasm|Adult Pineal Gland Neoplasm|Adult Pineal Gland Tumor|Adult Pineal Parenchymal Cell Tumor|Adult Pineal Parenchymal Neoplasm|Adult Pineal Parenchymal Tumor|Parenchymal Neoplasm of Adult Pineal Gland|Parenchymal Neoplasm of the Adult Pineal Gland|Parenchymal Tumor of Adult Pineal Gland|Parenchymal Tumor of the Adult Pineal Gland
C8274	Pineal_Gland_Astrocytoma	Astrocytic_Tumor|Pineal_Region_Neoplasm	Pineal Gland Astrocytoma|Astrocytic Neoplasm of Pineal Gland|Astrocytic Neoplasm of the Pineal Gland|Astrocytic Tumor of Pineal Gland|Astrocytic Tumor of the Pineal Gland|Astrocytoma of Pineal Gland|Astrocytoma of the Pineal Gland|Pineal Astrocytic Neoplasm|Pineal Astrocytic Tumor|Pineal Astrocytoma|Pineal Gland Astrocytic Neoplasm|Pineal Gland Astrocytic Tumor
C8275	Adult_Anaplastic_Malignant_Meningioma	Adult_Meningioma|Anaplastic_Malignant_Meningioma	Adult Anaplastic (Malignant) Meningioma|Adult Anaplastic Meningioma|Adult Malignant Meningioma
C8276	Skin_Integrity_Changes_Secondary_to_Cutaneous_Metastases	Integumentary_System_Finding	Skin Integrity Changes Secondary to Cutaneous Metastases
C8277	Localized_Unresectable_Neuroblastoma	Neuroblastoma	Localized Unresectable Neuroblastoma
C8278	Cancer-Related_Condition	Diseases_and_Disorders	Cancer-Related Condition|Cancer-Related Problem or Condition|Oncologic Complications|cancer related problem/condition|problem/condition, cancer related|problem/condition, cancer-related
C8279	Long-Term_Effects_Secondary_to_Cancer_Therapy_in_Children	Side_Effect	Long-Term Effects Secondary to Cancer Therapy in Children|cancer therapy in children, long term effects secondary to|cancer therapy in children, long-term effects secondary to|effects secondary to cancer therapy in children, long term|effects secondary to cancer therapy in children, long-term
C8280	Perioperative_Postoperative_Complications	Side_Effect	Perioperative/Postoperative Complications|complications, perioperative/postoperative|complications, postoperative/perioperative
C8281	Poor_Vascular_Access	Non-Neoplastic_Vascular_Disorder	Poor Vascular Access
C8282	Sexual_Dysfunction_and_Infertility	Genitourinary_Signs_and_Symptoms|Reproductive_System_Finding	Sexual Dysfunction and Infertility|dysfunction and infertility, sexual
C8283	Skin_Reactions_Secondary_to_Radiation_Therapy	Side_Effect	Skin Reactions Secondary to Radiation Therapy
C8284	AIDS-Related_Primary_Central_Nervous_System_Lymphoma	AIDS-Related_Lymphoma|Central_Nervous_System_Lymphoma	AIDS-Related Primary Central Nervous System Lymphoma|AIDS Related Lymphoma of Primary Central Nervous System|AIDS Related Lymphoma of the Primary Central Nervous System|AIDS Related Primary CNS Lymphoma|AIDS Related Primary Central Nervous System Lymphoma|AIDS-Related Lymphoma of Primary Central Nervous System|AIDS-Related Lymphoma of the Primary Central Nervous System|AIDS-Related Primary CNS Lymphoma
C8285	AIDS_Related_Immunoblastic_Lymphoma	AIDS-Related_Diffuse_Large_B-cell_Lymphoma|Immunoblastic_Lymphoma	AIDS Related Immunoblastic Lymphoma|AIDS Associated Immunoblastic Lymphoma|AIDS Related Immunoblastic Large Cell Lymphoma|AIDS-Associated Immunoblastic Large Cell Lymphoma
C8286	ENV_Gene	AIDS-Related_Non-Hodgkin_s_Lymphoma|Immunodeficiency-Related_Burkitt_s_Lymphoma	AIDS-Related Burkitt's Lymphoma|AIDS Related Burkitt's Lymphoma|AIDS Related Small Noncleaved Cell Lymphoma|AIDS-Associated Burkitt's Lymphoma|AIDS-Associated Small Noncleaved Cell Lymphoma|AIDS-Related Small Non-Cleaved Cell Lymphoma
C8287	Bilateral_Breast_Carcinoma	Bilateral_Carcinoma|Breast_Carcinoma	Bilateral Breast Carcinoma|Bilateral Breast Cancer
C8288	Known_Bone_Marrow_Involvement	Hematopoietic_System_Finding	Bone Marrow Involvement
C8289	Adult_Infiltrating_Astrocytoma	Adult_Astrocytic_Tumor	Adult Infiltrating Astrocytoma|Adult Infiltrating Astrocytic Neoplasm|Adult Infiltrating Astrocytic Tumor
C8290	Adult_Ependymoblastoma	Adult_Central_Nervous_System_Neoplasm|Ependymoblastoma	Adult Ependymoblastoma
C8291	Adult_Pineocytoma	Adult_Pineal_Parenchymal_Cell_Neoplasm|Pineocytoma	Adult Pineocytoma
C8292	Adult_Pineoblastoma	Adult_Pineal_Parenchymal_Cell_Neoplasm|Malignant_Adult_Brain_Neoplasm|Pineoblastoma	Adult Pineoblastoma
C8293	Adult_Papillary_Meningioma	Adult_Meningioma|Papillary_Meningioma	Adult Papillary Meningioma
C8294	Pancreatic_Adenocarcinoma	Adenocarcinoma|Pancreatic_Carcinoma	Pancreatic Adenocarcinoma|Adenocarcinoma of Pancreas|Adenocarcinoma of the Pancreas|Pancreas Adenocarcinoma	An adenocarcinoma which arises from the exocrine pancreas.  Ductal adenocarcinoma and its variants are the most common types of pancreatic adenocarcinoma. --2002
C8295	Respiratory_Papilloma	Benign_Lung_Neoplasm|Papilloma	Lung Papilloma|Papilloma of Respiratory Tract|Papilloma of the Respiratory Tract|Respiratory Tract Papilloma	A overgrowth of epithelial tissue in the respiratory tree.
C8296	AIDS-Related_Diffuse_Mixed_Cell_Lymphoma	AIDS-Related_Lymphoma_by_Working_Formulation|Diffuse_Malignant_Lymphoma|Diffuse_Mixed_Cell_Lymphoma	AIDS-Related Diffuse Mixed Cell Lymphoma|AIDS Associated Diffuse Mixed Cell Lymphoma|AIDS Related Diffuse Mixed Cell Lymphoma|AIDS-Associated Diffuse Mixed Cell Lymphoma
C8297	AIDS-Related_Diffuse_Small_Cleaved_Cell_Lymphoma	AIDS-Related_Lymphoma_by_Working_Formulation|Diffuse_Malignant_Lymphoma|Malignant_Non-Hodgkin_s_Lymphoma_Cleaved_Cell	AIDS-Related Diffuse Small Cleaved Cell Lymphoma|AIDS Associated Diffuse Small Cleaved Cell Lymphoma|AIDS Related Diffuse Small Cleaved Cell Lymphoma|AIDS-Associated Diffuse Small Cleaved Cell Lymphoma
C8298	AIDS-Related_Lymphoblastic_Lymphoma	AIDS-Related_Non-Hodgkin_s_Lymphoma|Precursor_Lymphoblastic_Lymphoma	AIDS-Related Lymphoblastic Lymphoma|AIDS Associated Lymphoblastic lymphoma|AIDS Related Lymphoblastic lymphoma|AIDS-Associated Lymphoblastic lymphoma
C8299	Primary_Systemic_Amyloidosis	Primary_Amyloidosis	Primary Systemic Amyloidosis
C8300	Desmoplastic_Small_Round_Cell_Tumor	Malignant_Miscellaneous_Mesenchymal_Neoplasm	Desmoplastic Small Round Cell Tumor|Desmoplastic Small Round-Cell Neoplasm|Desmoplastic Small Round-Cell Tumor|desmoplastic small round cell tumor	(dez-mo-PLAS-tik...) A rare, aggressive cancer that usually affects young males and usually is located in the abdomen.
C8301	Veno-Occlusive_Disease	Cancer-Related_Condition|Vascular_Disorder	Veno-Occlusive Disease|VOD|Vaso-Occlusive Disease	Disorder in which veins are partially or completely obstructed or the blood flow through the veins is suboptimal.--2004
C8302	Graft-Versus-Tumor_Induction	Pathologic_Process	Graft-Versus-Tumor Induction|graft versus host disease induction|graft versus tumor induction|graft-versus-tumor	An immune response that involves a reaction by immune cells that are present in transplanted tissue, such as bone marrow or peripheral blood, to a recipient's tumor cells. The introduction or transplantation of immune-sensitive moieties to a host are being evaluated in several clinical trials as a primary therapy for patients with malignancies.
C8303	Adult_Acute_Myeloid_Leukemia_Minimally_Differentiated	Acute_Myeloid_Leukemia_Minimally_Differentiated|Adult_Acute_Myeloid_Leukemia	Adult Acute Myeloid Leukemia Minimally Differentiated|Adult Acute Granulocytic Leukemia with Minimal Differentiation|Adult Acute M0 Leukemia|Adult Acute Minimally Differentiated Myeloid Leukemia (M0)|Adult Acute Myeloblastic Leukemia with Minimal Differentiation|Adult Acute Myelocytic Leukemia with Minimal Differentiation|Adult Acute Myelogenous Leukemia with Minimal Differentiation|M0 Adult AML|M0 Adult ANLL|M0 Adult Acute Granulocytic Leukemia with Minimal Differentiation|M0 Adult Acute Leukemia|M0 Adult Acute Myeloblastic Leukemia|M0 Adult Acute Myeloblastic Leukemia with Minimal Differentiation|M0 Adult Acute Myelocytic Leukemia|M0 Adult Acute Myelocytic Leukemia with Minimal Differentiation|M0 Adult Acute Myelogenous Leukemia|M0 Adult Acute Myelogenous Leukemia with Minimal Differentiation|M0 Adult Acute Myeloid Leukemia with Minimal Differentiation
C8304	Childhood_Acute_Myeloid_Leukemia_Minimally_Differentiated	Acute_Myeloid_Leukemia_Minimally_Differentiated|Childhood_Acute_Myeloid_Leukemia	Childhood Acute Myeloid Leukemia Minimally Differentiated|Childhood Acute M0 Leukemia|Childhood Acute Minimally Differentiated Myeloid Leukemia|Childhood Acute Minimally Differentiated Myeloid Leukemia (M0)|M0 Childhood Acute Minimally Differentiated Myeloid Leukemia|M0 Pediatric Acute Minimally Differentiated Myeloid Leukemia|Pediatric Acute M0 Leukemia|Pediatric Acute Minimally Differentiated Myeloid Leukemia
C8305	Stage_I_Childhood_Large_Cell_Lymphoma	Childhood_Large_Cell_Lymphoma	Stage I Childhood Large Cell Lymphoma|Childhood Large Cell Lymphoma Stage I|Pediatric Large Cell Lymphoma Stage I|Stage I Pediatric Large Cell Lymphoma
C8306	Stage_II_Childhood_Large_Cell_Lymphoma	Childhood_Large_Cell_Lymphoma	Stage II Childhood Large Cell Lymphoma|Childhood Large Cell Lymphoma Stage II|Pediatric Large Cell Lymphoma Stage II|Stage II Pediatric Large Cell Lymphoma
C8307	Stage_III_Childhood_Large_Cell_Lymphoma	Childhood_Large_Cell_Lymphoma	Stage III Childhood Large Cell Lymphoma|Childhood Large Cell Lymphoma Stage III|Pediatric Large Cell Lymphoma Stage III|Stage III Pediatric Large Cell Lymphoma
C8308	Stage_IV_Childhood_Large_Cell_Lymphoma	Childhood_Large_Cell_Lymphoma	Stage IV Childhood Large Cell Lymphoma|Childhood Large Cell Lymphoma Stage IV|Metastatic Childhood Large Cell Lymphoma|Metastatic Pediatric Large Cell Lymphoma|Pediatric Large Cell Lymphoma Stage IV|Stage IV Pediatric Large Cell Lymphoma
C8309	Recurrent_Childhood_Large_Cell_Lymphoma	Childhood_Large_Cell_Lymphoma	Recurrent Childhood Large Cell Lymphoma|Recurrent Pediatric Large Cell Lymphoma|Relapsed Childhood Large Cell Lymphoma|Relapsed Pediatric Large Cell Lymphoma
C8310	Childhood_Large_Cell_Lymphoma	Malignant_Lymphoma_Large_Cell_Type	Childhood Large Cell Lymphoma|Pediatric Large Cell Lymphoma
C8311	Fibrous_Polyp	Polyp	Fibrous Polyp
C8312	Leptomeningeal_Sarcoma	Malignant_Leptomeningeal_Neoplasm|Meningeal_Sarcoma	Leptomeningeal Sarcoma|Sarcoma of Leptomeninges|Sarcoma of the Leptomeninges
C8318	Stage_I_Lymphoma	Lymphoma_by_Stage	Stage I Lymphoma|Lymphoma Stage I
C8319	Stage_II_Lymphoma	Lymphoma_by_Stage	Stage II Lymphoma|Lymphoma Stage II
C8320	Stage_III_Lymphoma	Lymphoma_by_Stage	Stage III Lymphoma|Lymphoma Stage III
C8321	Stage_IV_Lymphoma	Lymphoma_by_Stage	Stage IV Lymphoma|Lymphoma Stage IV
C8322	Intracranial_Colloid_Cyst	Central_Nervous_System_Cyst	Intracranial Colloid Cyst	Colloid cysts i.e. cysts filled with gelatinous material, in the central nervous system often are found in the third ventricle. Due to their location, chronic or intermittent hydrocephalus can result. Case reports of sudden death due to acute obstructive hydrocephalus are in the literature. Colloid cysts are benign lesions that should be considered for neurosurgical resection.
C8323	Amyloid_Neoplasm	Benign_Miscellaneous_Mesenchymal_Neoplasm	Amyloid Neoplasm|Amyloid Tumor
C8324	Triploidy	Polyploidy	Triploidy
C8325	Dicentric_Chromosome	Chromosomal_Aberration	Dicentric Chromosome|dic
C8326	Cytologic_Atypia	Atypia	Cytologic Atypia|Atypical Cell Present
C8327	Mild_Cytologic_Atypia	Cytologic_Atypia	Mild Cytologic Atypia
C8328	Moderate_Cytologic_Atypia	Cytologic_Atypia	Moderate Cytologic Atypia
C8329	Severe_Cytologic_Atypia	Cytologic_Atypia|Precancerous_Atypia	Severe Cytologic Atypia
C8330	Squamous_Cell_Atypia	Cytologic_Atypia	Squamous Cell Atypia
C8331	Mild_Squamous_Cell_Atypia	Squamous_Cell_Atypia	Mild Squamous Cell Atypia
C8332	Moderate_Squamous_Cell_Atypia	Squamous_Cell_Atypia	Moderate Squamous Cell Atypia
C8333	Severe_Squamous_Cell_Atypia	Severe_Cytologic_Atypia|Squamous_Cell_Atypia	Severe Squamous Cell Atypia
C8334	Squamous_Cell_Intraepithelial_Neoplasia	Intraepithelial_Neoplasia|Squamous_Cell_Neoplasm	Squamous Cell Intraepithelial Neoplasia|SIL|SIN|Squamous Intraepithelial Lesion|squamous intraepithelial lesion	(SKWAY-mus in-tra-eh-pih-THEEL-ee-ul LEE-zhun) SIL. A general term for the abnormal growth of squamous cells on the surface of the cervix. The changes in the cells are described as low grade or high grade, depending on how much of the cervix is affected and how abnormal the cells appear.
C8335	Low_Grade_Squamous_Intraepithelial_Neoplasia	Low_Grade_Intraepithelial_Neoplasia|Squamous_Cell_Intraepithelial_Neoplasia	Low Grade Squamous Intraepithelial Neoplasia|Grade 1 Squamous Intraepithelial Neoplasia|Grade I Squamous Intraepithelial Neoplasia|LSIL|Low-Grade Squamous Intraepithelial Lesion
C8336	High-Grade_Squamous_Intraepithelial_Neoplasia	High_Grade_Intraepithelial_Neoplasia|Squamous_Cell_Intraepithelial_Neoplasia	High Grade Squamous Intraepithelial Neoplasia|HSIL|High-Grade Squamous Intraepithelial Lesion|high-grade squamous intraepithelial lesion	HSIL. A precancerous condition in which the cells of the uterine cervix are moderately or severely abnormal.
C8337	Columnar_Cell_Atypia	Glandular_Cell_Atypia	Columnar Cell Atypia
C8338	Mild_Columnar_Cell_Atypia	Columnar_Cell_Atypia|Mild_Glandular_Cell_Atypia	Mild Columnar Cell Atypia
C8339	Moderate_Columnar_Cell_Atypia	Columnar_Cell_Atypia|Moderate_Glandular_Cell_Atypia	Moderate Columnar Cell Atypia
C8340	Severe_Columnar_Cell_Atypia	Columnar_Cell_Atypia|Severe_Glandular_Cell_Atypia	Severe Columnar Cell Atypia
C8341	Glandular_Cell_Atypia	Cytologic_Atypia	Glandular Cell Atypia
C8342	Mild_Glandular_Cell_Atypia	Glandular_Cell_Atypia	Mild Glandular Cell Atypia
C8343	Moderate_Glandular_Cell_Atypia	Glandular_Cell_Atypia	Moderate Glandular Cell Atypia
C8344	Severe_Glandular_Cell_Atypia	Glandular_Cell_Atypia|Severe_Cytologic_Atypia	Severe Glandular Cell Atypia
C8345	Transitional_Cell_Atypia	Cytologic_Atypia	Transitional Cell Atypia
C8346	Mild_Transitional_Cell_Atypia	Transitional_Cell_Atypia	Mild Transitional Cell Atypia
C8347	Moderate_Transitional_Cell_Atypia	Transitional_Cell_Atypia	Moderate Transitional Cell Atypia
C8348	Severe_Transitional_Cell_Atypia	Severe_Cytologic_Atypia|Transitional_Cell_Atypia	Severe Transitional Cell Atypia
C8349	Post-Radiation_Cytologic_Changes_with_Dysplasia	Cytologic_Atypia	Post-Radiation Cytologic Changes with Dysplasia
C8350	Atypia_Suspicious_for_Malignancy	Cytologic_Atypia|Precancerous_Atypia	Atypia Suspicious for Malignancy
C8351	Koilocytotic_Atypia	Cytologic_Atypia	Koilocytotic Atypia|Koilocytosis	An abnormality often noted in pap smears.  Koilocytotic atypia affects the squamous epithelium of the transformation zone. The cells involved show cytoplasmic vacuolization that might be related to their ability to store glycogen. The most characteristic feature of this condition is the peripheral cytoplasmic condensation associated with an increase of tonofilaments. (from Acta Cytol 1981;25:377-82 )
C8352	Mild_Koilocytotic_Atypia	Koilocytotic_Atypia	Mild Koilocytotic Atypia
C8353	Moderate_Koilocytotic_Atypia	Koilocytotic_Atypia	Moderate Koilocytotic Atypia
C8354	Severe_Koilocytotic_Atypia	Koilocytotic_Atypia|Severe_Cytologic_Atypia	Severe Koilocytotic Atypia
C8355	Atypical_Hyperplasia	Cellular_Precursor_of_Cancer|Hyperplasia	Atypical Hyperplasia|atypical hyperplasia	(hy-per-PLAY-zha) A benign (noncancerous) condition in which cells have abnormal features and are increased in number.
C8356	Atypical_Glandular_Hyperplasia	Atypical_Hyperplasia	Atypical Glandular Hyperplasia
C8357	Atypical_Squamous_Metaplasia	Atypical_Metaplasia|Squamous_Metaplasia	Atypical Squamous Metaplasia|Squamous Metaplasia with Atypia
C8358	Glandular_Metaplasia	Metaplasia	Glandular Metaplasia
C8359	Apocrine_Metaplasia	Glandular_Metaplasia	Apocrine Metaplasia
C8360	Intestinal_Metaplasia	Metaplasia	Intestinal Metaplasia
C8361	Gastric_Metaplasia	Metaplasia	Gastric Metaplasia
C8362	Mild_Dysplasia	Dysplasia	Mild Dysplasia
C8363	Moderate_Dysplasia	Dysplasia	Moderate Dysplasia
C8364	Severe_Dysplasia	Dysplasia	Severe Dysplasia
C8365	Fibrocystic_Disease_Proliferative_Type_with_Atypia	Breast_Fibrocystic_Change_Proliferative_Type	Fibrocystic Disease, Proliferative Type with Atypia
C8366	Intraepithelial_Neoplasia	Epithelial_Neoplasm	Intraepithelial Neoplasia|Epithelial Dysplasia|Intraepithelial Neoplasm
C8367	Low_Grade_Intraepithelial_Neoplasia	Intraepithelial_Neoplasia	Low Grade Intraepithelial Neoplasia|Grade 1 Intraepithelial Neoplasia|Grade I Intraepithelial Neoplasia|Mild Epithelial Dysplasia
C8368	Grade_II_Intraepithelial_Neoplasia	High_Grade_Intraepithelial_Neoplasia	Grade II Intraepithelial Neoplasia|Grade 2 Intraepithelial Neoplasia|Moderate Epithelial Dysplasia
C8369	Grade_III_Intraepithelial_Neoplasia	High_Grade_Intraepithelial_Neoplasia	Grade III Intraepithelial Neoplasia|Grade 3 Intraepithelial Neoplasia|Severe Epithelial Dysplasia
C8370	Fibrous_Hamartoma	Retired_Concepts	Fibrous Hamartoma
C8371	Collagen_Nevus	Hamartoma|Non-Neoplastic_Nevus	Connective Tissue Nevus|Collagen Hamartoma|Collagen Nevus|Collagenoma
C8372	Hamartomatous_Polyp	Hamartoma|Polyp	Hamartomatous Polyp
C8373	Lymphangiomatosis	Benign_Lymphatic_Vessel_Neoplasm	Lymphangiomatosis
C8374	Bowenoid_Papulosis	Pre-Malignant_Skin_Epithelial_Lesions	Bowenoid Papulosis
C8376	Adenocarcinoma_in_situ_in_Villous_Adenoma	Adenocarcinoma_in_Villous_Adenoma|Adenocarcinoma_in_situ_in_Adenomatous_Polyp	Adenocarcinoma In Situ in Villous Adenoma
C8377	Papillary_Serous_Cystadenocarcinoma	Papillary_Cystadenocarcinoma|Serous_Cystadenocarcinoma	Papillary Serous Cystadenocarcinoma|Papillary Serous Adenocarcinoma|Papillary Serous Carcinoma|papillary serous carcinoma	An aggressive cancer that usually affects the uterus/endometrium, peritoneum, or ovary.
C8380	Giant_Cell_Fibrous_Histiocytoma	Malignant_Fibrous_Histiocytoma|Malignant_Giant_Cell_Neoplasm|Sarcoma_Differentiation_Score_3	Giant Cell Fibrous Histiocytoma|Malignant Giant Cell Neoplasm of Soft Parts|Malignant Giant Cell Tumor of Soft Parts	A morphologic variant of malignant fibrous histiocytoma, characterized by osteoclast-like giant cells and cellular pleomorphism. -- 2003
C8381	Gigantiform_Cementoma	Cementoma	Gigantiform Cementoma|Florid Osseous Dysplasia
C8382	Anaplastic_Choroid_Plexus_Papilloma	Choroid_Plexus_Neoplasm	Atypical Choroid Plexus Papilloma	The distinction between choroid plexus papilloma and choroid plexus carcinoma is not always clear-cut, as some tumors show only one or few histological features of malignancy, e.g. increased mitotic activity.  These tumors have been termed "atypical choroid plexus papilloma", but clear diagnostic criteria have not been established (WHO, 2000).  2004
C8383	Renal_Adenoma	Adenoma|Renal_Neoplasm	Renal Adenoma
C8384	Endometrial_Stromal_Neoplasm	Stromal_Neoplasm	Endometrial Stromal Neoplasm|Endometrial Stromal Tumor
C8385	Malignant_Myoepithelioma	Retired_Concepts	Malignant Myoepithelioma
C8387	Childhood_Cerebral_Diffuse_Astrocytoma	Childhood_Cerebral_Astrocytoma|Diffuse_Astrocytoma	Childhood Cerebral Diffuse Astrocytoma
C8388	Functioning_Pituitary_Gland_Adenoma	Functioning_Pituitary_Gland_Neoplasm|Pituitary_Gland_Adenoma	Functioning Pituitary Gland Adenoma|Functioning Adenoma of Pituitary|Functioning Adenoma of Pituitary Gland|Functioning Adenoma of the Pituitary|Functioning Adenoma of the Pituitary Gland|Functioning Pituitary Adenoma|Functioning Pituitary Gland Adenoma (Benign)|Secretory Adenoma of Pituitary|Secretory Adenoma of Pituitary Gland|Secretory Adenoma of the Pituitary|Secretory Adenoma of the Pituitary Gland|Secretory Pituitary Adenoma|Secretory Pituitary Gland Adenoma	A hormone producing pituitary gland adenoma, associated with a hormonal syndrome. (NCI05)
C8389	Recurrent_Childhood_Cerebellar_Astrocytoma	Childhood_Cerebellar_Astrocytoma|Recurrent_Childhood_Brain_Neoplasm	Recurrent Childhood Cerebellar Astrocytoma|Recurrent Childhood Astrocytic Neoplasm of Cerebellum|Recurrent Childhood Astrocytic Neoplasm of the Cerebellum|Recurrent Childhood Astrocytic Tumor of Cerebellum|Recurrent Childhood Astrocytic Tumor of the Cerebellum|Recurrent Childhood Astrocytoma of Cerebellum|Recurrent Childhood Astrocytoma of the Cerebellum|Recurrent Pediatric Astrocytic Tumor of Cerebellum|Recurrent Pediatric Astrocytic Tumor of the Cerebellum|Recurrent Pediatric Astrocytoma of Cerebellum|Recurrent Pediatric Astrocytoma of the Cerebellum|Recurrent Pediatric Cerebellar Astrocytic Neoplasm|Recurrent Pediatric Cerebellar Astrocytoma|Relapsed Childhood Astrocytic Tumor of Cerebellum|Relapsed Childhood Astrocytic Tumor of the Cerebellum|Relapsed Childhood Astrocytoma of Cerebellum|Relapsed Childhood Astrocytoma of the Cerebellum|Relapsed Childhood Cerebellar Astrocytic Neoplasm|Relapsed Childhood Cerebellar Astrocytic Tumor|Relapsed Childhood Cerebellar Astrocytoma|Relapsed Pediatric Astrocytic Tumor of Cerebellum|Relapsed Pediatric Astrocytic Tumor of the Cerebellum|Relapsed Pediatric Astrocytoma of Cerebellum|Relapsed Pediatric Astrocytoma of the Cerebellum|Relapsed Pediatric Cerebellar Astrocytic Tumor|Relapsed Pediatric Cerebellar Astrocytoma	Regrowth of benign and malignant childhood cerebellar astrocytomas that have previously been subjected to surgical resection and less frequently other forms of therapy such as radiation or chemotherapy.  Recurrence of benign tumors (e.g., (pilocytic astrocytoma) may respond to a second surgical procedure.  (KEV 8-7-99)
C8390	Anal_Leukoplakia	Leukoplakia	Anal Leukoplakia|Leukoplakia of Anus|Leukoplakia of the Anus
C8391	Squamous_Metaplasia_of_Bladder	Squamous_Metaplasia	Squamous Metaplasia of Bladder
C8392	Upper_Gingival_Carcinoma	Gingival_Carcinoma	Upper Gingival Carcinoma|Carcinoma of Upper Gingiva|Carcinoma of Upper Gum|Carcinoma of the Upper Gingiva|Carcinoma of the Upper Gum|Upper Gum Carcinoma
C8393	Lower_Gingival_Carcinoma	Gingival_Carcinoma	Lower Gingival Carcinoma|Carcinoma of Lower Gingiva|Carcinoma of Lower Gum|Carcinoma of the Lower Gingiva|Carcinoma of the Lower Gum|Lower Gum Carcinoma
C8394	Hard_Palate_Carcinoma	Malignant_Hard_Palate_Neoplasm|Palate_Carcinoma	Hard Palate Carcinoma|Carcinoma of Hard Palate|Carcinoma of the Hard Palate
C8395	Soft_Palate_Carcinoma	Malignant_Soft_Palate_Neoplasm|Oropharyngeal_Carcinoma|Palate_Carcinoma	Soft Palate Carcinoma|Carcinoma of Soft Palate|Carcinoma of the Soft Palate
C8396	Submandibular_Gland_Carcinoma	Major_Salivary_Gland_Carcinoma|Malignant_Submandibular_Gland_Neoplasm	Submandibular Gland Carcinoma|Carcinoma of Submandibular Gland|Carcinoma of the Submandibular Gland
C8397	Sublingual_Gland_Carcinoma	Major_Salivary_Gland_Carcinoma|Malignant_Sublingual_Gland_Neoplasm	Sublingual Gland Carcinoma|Carcinoma of Sublingual Gland|Carcinoma of the Sublingual Gland
C8398	Gastric_Fundus_Carcinoma	Gastric_Carcinoma	Gastric Fundus Carcinoma|Cancer of Fundus of Stomach|Cancer of Gastric Fundus|Cancer of the Fundus of the Stomach|Cancer of the Gastric Fundus|Carcinoma of Fundus of Stomach|Carcinoma of Gastric Fundus|Carcinoma of the Fundus of the Stomach|Carcinoma of the Gastric Fundus|Gastric Fundus Cancer
C8399	Gastric_Body_Carcinoma	Gastric_Carcinoma	Gastric Body Carcinoma|Cancer of Body of Stomach|Cancer of Gastric Body|Cancer of the Body of the Stomach|Cancer of the Gastric Body|Carcinoma of Body of Stomach|Carcinoma of Gastric Body|Carcinoma of the Body of the Stomach|Carcinoma of the Gastric Body|Gastric Body Cancer
C8400	Carcinoma_in_situ_of_the_Antrum	Gastric_Carcinoma	Carcinoma In Situ of the Antrum|Carcinoma in situ of Antrum|Gastric Antrum Carcinoma in situ|Stage 0 Carcinoma of Gastric Antrum|Stage 0 Carcinoma of the Gastric Antrum
C8401	Jejunal_Neoplasm	Small_Intestinal_Neoplasm	Jejunal Neoplasm|Jejunal Tumor|Neoplasm of Jejunum|Neoplasm of the Jejunum|Tumor of Jejunum|Tumor of the Jejunum
C8402	Fibrohistiocytic_Neoplasm	Mesenchymal_Cell_Neoplasm	Fibrohistiocytic Neoplasm|Fibrohistiocytic Tumor
C8403	Malignant_Ovarian_Granulosa_Cell_Tumor	Malignant_Granulosa_Cell_Tumor|Malignant_Ovarian_Sex_Cord-Stromal_Tumor|Ovarian_Granulosa_Cell_Tumor	Malignant Ovarian Granulosa Cell Tumor|Malignant Granulosa Cell Neoplasm of Ovary|Malignant Granulosa Cell Neoplasm of the Ovary|Malignant Granulosa Cell Tumor of Ovary|Malignant Granulosa Cell Tumor of the Ovary|Malignant Ovarian Granulosa Cell Neoplasm
C8404	Renal_Pelvis_Neoplasm	Renal_Neoplasm	Renal Pelvis Neoplasm|Kidney Pelvis Neoplasm|Kidney Pelvis Tumor|Neoplasm of Kidney Pelvis|Neoplasm of Renal Pelvis|Neoplasm of the Kidney Pelvis|Neoplasm of the Renal Pelvis|Renal Pelvis Tumor|Tumor of Kidney Pelvis|Tumor of Renal Pelvis|Tumor of the Kidney Pelvis|Tumor of the Renal Pelvis
C8405	Benign_Choroid_Plexus_Neoplasm	Benign_Brain_Neoplasm|Choroid_Plexus_Neoplasm	Benign Choroid Plexus Neoplasm|Benign Choroid Plexus Neoplasms|Benign Choroid Plexus Tumor|Benign Choroid Plexus Tumors|Benign Neoplasm of Choroid Plexus|Benign Neoplasm of the Choroid Plexus|Benign Tumor of Choroid Plexus|Benign Tumor of the Choroid Plexus
C8407	Posterior_Tongue_Carcinoma	Malignant_Posterior_Tongue_Neoplasm|Oropharyngeal_Carcinoma|Tongue_Carcinoma	Posterior Tongue Carcinoma|Base of Tongue Carcinoma|Base of the Tongue Carcinoma|Carcinoma of Base of Tongue|Carcinoma of Posterior Tongue|Carcinoma of the Base of the Tongue|Carcinoma of the Posterior Tongue
C8408	Malignant_Sternal_Neoplasm	Malignant_Thoracic_Neoplasm|Sternal_Neoplasm	Malignant Sternal Neoplasm|Malignant Neoplasm of Sternum|Malignant Neoplasm of the Sternum|Malignant Sternal Tumor|Malignant Tumor of Sternum|Malignant Tumor of the Sternum
C8409	Malignant_Sebaceous_Neoplasm	Malignant_Skin_Appendage_Neoplasm|Sebaceous_Neoplasm	Malignant Sebaceous Neoplasm|Malignant Neoplasm of Sebaceous Gland|Malignant Neoplasm of the Sebaceous Gland|Malignant Sebaceous Gland Neoplasm|Malignant Sebaceous Gland Tumor|Malignant Sebaceous Tumor|Malignant Tumor of Sebaceous Gland|Malignant Tumor of the Sebaceous Gland
C8410	Breast_Melanoma	Malignant_Breast_Neoplasm|Melanoma	Breast Melanoma|Malignant Breast Melanoma|Malignant Melanoma of Breast|Malignant Melanoma of the Breast
C8411	Metastatic_Neoplasm_to_the_Colon	Malignant_Colon_Neoplasm|Metastatic_Neoplasm_to_the_Large_Intestine	Metastatic Malignant Neoplasm to the Colon|Metastatic Neoplasm to the Colon|Metastatic Tumor to the Colon
C8412	Stage_IV_Rectal_Cancer	Rectal_Carcinoma|Stage_IV_Colorectal_Cancer	Stage IV Rectal Cancer|AJCC Stage IV Rectal Cancer|Astler-Coller D Rectal Carcinoma|Dukes D Carcinoma of Rectum|Dukes D Carcinoma of the Rectum|Dukes D Rectal Carcinoma|Metastatic Rectal Cancer|Metastatic Rectal Carcinoma|Rectal Cancer Stage IV|Stage IV Carcinoma of Rectum|Stage IV Carcinoma of the Rectum|Stage IV Rectal Carcinoma	Stage IV includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 6th ed.) - 2003
C8414	Benign_Supraglottis_Neoplasm	Benign_Laryngeal_Neoplasm|Supraglottis_Neoplasm	Benign Supraglottis Neoplasm|Benign Neoplasm of Supraglottis|Benign Neoplasm of the Supraglottis|Benign Supraglottic Neoplasm|Benign Supraglottic Tumor|Benign Supraglottis Tumor|Benign Tumor of Supraglottis|Benign Tumor of the Supraglottis
C8415	Benign_Pancreatic_Duct_Neoplasm	Retired_Concepts	Benign Pancreatic Duct Neoplasm|Benign Neoplasm of Pancreatic Duct|Benign Neoplasm of the Pancreatic Duct|Benign Pancreatic Duct Tumor|Benign Tumor of Pancreatic Duct|Benign Tumor of the Pancreatic Duct
C8416	Benign_Sternal_Neoplasm	Benign_Thoracic_Neoplasm|Sternal_Neoplasm	Benign Sternal Neoplasm|Benign Neoplasm of Sternum|Benign Neoplasm of the Sternum|Benign Sternal Tumor|Benign Tumor of Sternum|Benign Tumor of the Sternum
C8417	Benign_Ear_Neoplasm	Ear_Neoplasm	Benign Ear Neoplasm|Aural Neoplasms, Benign|Benign Ear Tumor|Benign Neoplasm of Ear|Benign Neoplasm of the Ear|Benign Tumor of Ear|Benign Tumor of the Ear
C8418	Benign_Bartholin_s_Gland_Neoplasm	Bartholin_s_Gland_Neoplasm|Benign_Vulvar_Neoplasm	Benign Bartholin's Gland Neoplasm|Benign Bartholin's Gland Tumor|Benign Neoplasm of Bartholin's Gland|Benign Neoplasm of the Bartholin's Gland|Benign Tumor of Bartholin's Gland|Benign Tumor of the Bartholin's Gland
C8419	Dysplastic_Cerebellar_Gangliocytoma	Cerebellar_Neuronal_and_Mixed_Neuronal-Glial_Tumor	Dysplastic Cerebellar Gangliocytoma|Dysplastic Gangliocytoma of Cerebellum|Dysplastic Gangliocytoma of the Cerebellum|Lhermitte-Duclos Disease	Dysplastic Gangliocytoma of the Cerebellum (WHO grade I), also called Lhermitte-Duclos disease, is a benign cerebellar mass, which occurs in young adults and is composed of dysplastic ganglion cells.  It is the major CNS manifestation of Cowden Disease, an autosomal dominant condition that causes a variety of hamartomas and neoplasms.(Adapted from WHO.)
C8420	Diffuse_Malignant_Mesothelioma	Malignant_Mesothelioma	Diffuse Malignant Mesothelioma|Malignant Diffuse Mesothelioma
C8421	Uterine_Cervix_Condyloma_Acuminatum	Cervical_Squamous_Neoplasm|Condyloma_Acuminatum	Cervical Condyloma Acuminatum|Cervical Condyloma|Cervix Condylomata|Cervix Condylomata Acuminata|Cervix Uteri Condyloma|Condyloma of Cervix|Condyloma of Cervix Uteri|Condyloma of Uterine Cervix|Condyloma of the Cervix|Condyloma of the Cervix Uteri|Condyloma of the Uterine Cervix|Condylomata Acuminata of Cervix|Condylomata Acuminata of Cervix Uteri|Condylomata Acuminata of Uterine Cervix|Condylomata Acuminata of the Cervix|Condylomata Acuminata of the Cervix Uteri|Condylomata Acuminata of the Uterine Cervix|Uterine Cervix Condyloma|Uterine Cervix Condyloma Acuminatum
C8422	Cementifying_Fibroma	Benign_Odontogenic_Neoplasm|Fibroma	Cementifying Fibroma
C8423	Stage_0_Melanoma_of_the_Skin	Cutaneous_Melanoma|Melanoma_in_situ	Stage 0 Skin Melanoma|Cutaneous Melanoma in situ|Malignant Cutaneous Melanoma in situ|Malignant Skin Melanoma in situ|Melanoma in situ of Skin|Melanoma in situ of the Skin|Skin Melanoma in situ|Stage 0 Cutaneous Melanoma|Stage 0 Malignant Cutaneous Melanoma|Stage 0 Malignant Melanoma|Stage 0 Malignant Skin Melanoma|Stage 0 Melanoma|Stage 0 Melanoma of Skin|Stage 0 Melanoma of the Skin	Stage 0 includes: Tis, N0, M0.  Tis: Melanoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. - 2003
C8425	Leukoplakia_of_Buccal_Mucosa	Mouth_Mucous_Membrane_Leukoplakia	Leukoplakia of Buccal Mucosa
C8426	Diffuse_Neurofibroma	Neurofibroma	Diffuse Neurofibroma
C8427	Vagus_Nerve_Paraganglioma	Parasympathetic_Paraganglioma|Vagus_Nerve_Neoplasm	Vagus Nerve Paraganglioma|Paraganglioma of Vagal Body|Paraganglioma of Vagus Nerve|Paraganglioma of the Vagal Body|Paraganglioma of the Vagus Nerve|Vagal Body Paraganglioma|Vagal Paraganglioma	A benign or malignant extra-adrenal parasympathetic paraganglioma arising from paraganglia in the vagus nerve.  Patients may present with a slow growing, painless mass in the neck, hoarseness, vocal cord paralysis, and dysphagia.
C8428	Tympanic_Paraganglioma	Middle_Ear_Paraganglioma	Tympanic Paraganglioma	A benign or malignant middle ear paraganglioma arising from paraganglia around the tympanum.  Signs and symptoms include a mass behind the tympanum, tinnitus, and conductive hearing loss.
C8429	Papillary_Epithelial_Neoplasm	Epithelial_Neoplasm|Papillary_Neoplasm	Papillary Epithelial Neoplasm
C8430	Ovarian_Papillary_Neoplasm	Ovarian_Epithelial_Neoplasm|Papillary_Epithelial_Neoplasm	Ovarian Papillary Tumor|Ovarian Papillary Neoplasm|Papillary Neoplasm of Ovary|Papillary Neoplasm of the Ovary|Papillary Tumor of Ovary|Papillary Tumor of the Ovary
C8431	Ovarian_Serous_Neoplasm	Ovarian_Epithelial_Neoplasm|Serous_Neoplasm	Ovarian Serous Tumor|Ovarian Serous Neoplasm|Serous Neoplasm of Ovary|Serous Neoplasm of the Ovary|Serous Tumor of Ovary|Serous Tumor of the Ovary
C8432	Borderline_Ovarian_Serous_Surface_Papilloma	Retired_Concepts	Borderline Ovarian Serous Surface Papilloma|Ovarian Surface Papilloma of Borderline Malignancy
C8433	Microcalcification	Calcification	Microcalcification|Breast Microcalcification|MICCA|Microcalcifications|microcalcifications	(MY-krow-kal-si-fi-KAY-shunz) Tiny deposits of calcium in the breast that cannot be felt but can be detected on a mammogram. A cluster of these very small specks of calcium may indicate that cancer is present.
C8434	Atypical_Squamous_Cell_of_Undetermined_Significance	Atypical_Cells_of_Uncertain_Significance|Atypical_Squamous_Cell	Atypical Squamous Cell of Undetermined Significance|ASCUS|Atypical Squamous Cell of Uncertain Significance
C8435	Atypical_Glandular_Cells_of_Uncertain_Significance	Atypical_Cells_of_Uncertain_Significance|Atypical_Glandular_Cell	Atypical Glandular Cell of Undetermined Significance|AGUS|Atypical Glandular Cell of Uncertain Significance|Atypical Glandular Cells of Uncertain Significance|Atypical Glandular Cells of Undetermined Significance
C8436	Atypical_Ductal_Breast_Hyperplasia	Atypical_Hyperplasia_of_the_Breast|Ductal_Breast_Hyperplasia|Mammary_Intraepithelial_Neoplasia_Ductal_Type	Atypical Ductal Breast Hyperplasia|ADH|Atypical Breast Ductal Hyperplasia|Atypical Ductal Hyperplasia of Breast|Atypical Ductal Hyperplasia of the Breast|DIN 1B|Ductal Intraepithelial Neoplasia, Grade 1B
C8438	Atypical_Gastric_Metaplasia	Atypical_Metaplasia|Gastric_Metaplasia	Atypical Gastric Metaplasia
C8439	Ectopic_Renin_Secretion	Ectopic_Hormone_Secretion_Syndromes_Associated_with_Neoplasia	Ectopic Renin Secretion	Abnormal secretion of renin in conjunction with neoplastic growth occurring anywhere in the body.
C8440	Ectopic_Growth_Hormone_Secretion	Ectopic_Hormone_Secretion_Syndromes_Associated_with_Neoplasia	Ectopic Growth Hormone Secretion	Abnormal secretion of growth hormone in conjunction with neoplastic growth occurring anywhere in the body.
C8441	Ectopic_Prolactin_Secretion	Ectopic_Hormone_Secretion_Syndromes_Associated_with_Neoplasia	Ectopic Prolactin Secretion	Abnormal secretion of prolactin in conjunction with neoplastic growth occurring anywhere in the body.
C8442	Ectopic_Aldosterone_Secretion	Ectopic_Hormone_Secretion_Syndromes_Associated_with_Neoplasia	Ectopic Aldosterone Secretion	Abnormal secretion of aldosterone in conjunction with neoplastic growth occurring anywhere in the body.
C8443	Ectopic_Calcitonin_Secretion	Ectopic_Hormone_Secretion_Syndromes_Associated_with_Neoplasia	Ectopic Calcitonin Secretion|Ectopic Calcitonin Production	Abnormal secretion of calcitonin in conjunction with neoplastic growth occurring anywhere in the body.
C8444	Ectopic_Chorionic_Gonadotropin_Secretion	Ectopic_Hormone_Secretion_Syndromes_Associated_with_Neoplasia	Ectopic Chorionic Gonadotropin Secretion	Abnormal secretion of chorionic gonadotropin in conjunction with neoplastic growth occurring anywhere in the body.
C8445	Atypical_Cells_of_Uncertain_Significance	Abnormal_Cell	Atypical Cell of Undetermined Significance|Atypical Cell of Uncertain Significance
C8446	Atypical_Endocervical_Glandular_Cells_of_Uncertain_Significance	Atypical_Glandular_Cells_of_Uncertain_Significance	Atypical Endocervical Glandular Cell of Undetermined Significance|Atypical Endocervical Glandular Cell of Uncertain Significance|Atypical Endocervical Glandular Cells of Uncertain Significance|Atypical Endocervical Glandular Cells of Undetermined Significance
C8447	Atypical_Endometrial_Glandular_Cells_of_Uncertain_Significance	Atypical_Glandular_Cells_of_Uncertain_Significance	Atypical Endometrial Glandular Cell of Undetermined Significance|Atypical Endometrial Glandular Cell of Uncertain Significance
C8448	Mesenchymal_Cell_Atypia	Cytologic_Atypia	Mesenchymal Cell Atypia
C8450	Smooth_Muscle_Cell_Atypia	Cytologic_Atypia	Smooth Muscle Cell Atypia
C8452	Striated_Muscle_Cell_Atypia	Cytologic_Atypia	Striated Muscle Cell Atypia
C8454	Fibroblastic_Cell_Atypia	Cytologic_Atypia	Fibroblastic Cell Atypia
C8456	Atypical_Apocrine_Metaplasia	Apocrine_Metaplasia|Atypical_Metaplasia	Atypical Apocrine Metaplasia
C8457	Focal_Dysplasia	Dysplasia	Focal Dysplasia
C8458	Diffuse_Dysplasia	Dysplasia	Diffuse Dysplasia
C8459	Hepatosplenic_T-Cell_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|Hepatic_Non-Hodgkin_s_Lymphoma|Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma|Splenic_Non-Hodgkin_s_Lymphoma	Hepatosplenic T-Cell Lymphoma|Hepatosplenic Gamma/Delta T-Cell Lymphoma	An aggressive, extranodal, and systemic mature T-cell non-Hodgkin's lymphoma, derived from cytotoxic T-cells, usually of gamma/delta T-cell receptor type.  Patients usually manifest marked thrombocytopenia, often associated with anemia and leukocytosis. (WHO, 2001) -- 2003
C8460	Acute_Myeloid_Leukemia_Minimally_Differentiated	Acute_Myeloid_Leukemia_not_Otherwise_Categorized	Acute Myeloid Leukemia, Minimally Differentiated|AML with Minimal Differentiation|Acute Myeloblastic Leukemia with Minimal Differentiation|Acute Myeloblastic Leukemia, Minimally Differentiated|Acute Myelocytic Leukemia with Minimal Differentiation|Acute Myelogenous Leukemia with Minimal Differentiation|Acute Myeloid Leukemia with Minimal Differentiation|Acute Myeloid Leukemia with Minimal Differentiation (MO)|M0 Acute Granulocytic Leukemia|M0 Acute Granulocytic Leukemia with Minimal Differentiation|M0 Acute Myeloblastic Leukemia|M0 Acute Myelocytic Leukemia|M0 Acute Myelogenous Leukemia|M0 Acute Myelogenous Leukemia with Minimal Differentiation|M0 Myeloid Leukemia|M0 Myeloid Leukemia with Minimal Differentiation	An acute myeloid leukemia (AML) in which the blasts do not show evidence of myeloid differentiation by morphology and conventional cytochemistry.  The myeloid origin of the blasts is demonstrated by immunohistochemistry and/or electron microscopic studies.  The patients present with anemia, neutropenia, and thrombocytopenia.  The prognosis is usually poor.  (WHO, 2001) -- 2003
C8461	Tibial_Adamantinoma	Adamantinoma_of_Long_Bones	Tibial Adamantinoma
C8463	Palate_Carcinoma	Malignant_Palate_Neoplasm|Oral_Cavity_Carcinoma	Palate Carcinoma|Carcinoma of Palate|Carcinoma of the Palate
C8464	Stage_I_Indolent_Adult_Non-Hodgkin_s_Lymphoma	Indolent_Adult_Non-Hodgkin_s_Lymphoma	Stage I Indolent Adult Non-Hodgkin's Lymphoma|Indolent Adult Non-Hodgkin's Lymphoma Stage I|Indolent Stage I Adult Non-Hodgkin's Lymphoma
C8465	Stage_I_Mantle_Cell_Lymphoma	Mantle_Cell_Lymphoma|Stage_I_B-Cell_Non-Hodgkin_s_Lymphoma	Stage I Mantle Cell Lymphoma|Mantle Cell Lymphoma Stage I	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).-2003
C8466	Stage_II_Contiguous_Adult_Non-Hodgkin_s_Lymphoma	Stage_II_Adult_Non-Hodgkin_s_Lymphoma	Stage II Contiguous Adult Non-Hodgkin's Lymphoma|Adult Contiguous Non-Hodgkin's Lymphoma Stage II|Adult Contiguous Non-Hodgkins Lymphoma Stage II|Adult Contiguous NonHodgkin's Lymphoma Stage II|Adult Contiguous NonHodgkins Lymphoma Stage II|Adult Contiguous Stage II Non-Hodgkin's Lymphoma|Contiguous Adult Non-Hodgkin's Lymphoma Stage II|Contiguous Stage II Adult Non-Hodgkin's Lymphoma|Stage II Adult Contiguous Non-Hodgkin's Lymphoma|Stage II Adult Contiguous Non-Hodgkins Lymphoma|Stage II Adult Contiguous NonHodgkin's Lymphoma|Stage II Adult Contiguous NonHodgkins Lymphoma
C8467	Stage_II_Contiguous_Adult_Indolent_Non-Hodgkin_s_Lymphoma	Indolent_Adult_Non-Hodgkin_s_Lymphoma|Stage_II_Contiguous_Adult_Non-Hodgkin_s_Lymphoma	Stage II Contiguous Adult Indolent Non-Hodgkin's Lymphoma|Adult Indolent Contiguous Non-Hodgkin's Lymphoma Stage II|Indolent Adult Contiguous Non-Hodgkin's Lymphoma Stage II|Indolent Adult Contiguous Non-Hodgkins Lymphoma Stage II|Indolent Adult Contiguous NonHodgkin's Lymphoma Stage II|Indolent Adult Contiguous NonHodgkins Lymphoma Stage II|Indolent Adult Contiguous Stage II Non-Hodgkin's Lymphoma|Indolent Contiguous Stage II Adult Non-Hodgkin's Lymphoma|Stage II Indolent Adult Contiguous Non-Hodgkin's Lymphoma|Stage II Indolent Adult Contiguous Non-Hodgkins Lymphoma|Stage II Indolent Adult Contiguous NonHodgkin's Lymphoma|Stage II Indolent Adult Contiguous NonHodgkins Lymphoma
C8468	Stage_II_Grade_1_Contiguous_Follicular_Lymphoma	Stage_II_Grade_1_Follicular_Lymphoma	Stage II Grade 1 Contiguous Follicular Lymphoma|Contiguous Follicular Small Cleaved Cell Lymphoma Stage II|Contiguous Grade I Follicular Lymphoma Stage II|Contiguous Grade I Follicular Small Cleaved Cell Lymphoma Stage II|Contiguous Stage II Follicular Small Cleaved Cell Lymphoma|Contiguous Stage II Grade I Follicular Lymphoma|Contiguous Stage II Grade I Follicular Small Cleaved Cell Lymphoma|Stage II Contiguous Follicular Small Cleaved Cell Lymphoma
C8469	Stage_II_Grade_2_Contiguous_Follicular_Lymphoma	Stage_II_Grade_2_Follicular_Lymphoma	Stage II Grade 2 Contiguous Follicular Lymphoma|Contiguous Follicular Mixed Cell Lymphoma Stage II|Contiguous Grade II Follicular Lymphoma Stage II|Contiguous Grade II Follicular Mixed Cell Lymphoma Stage II|Contiguous Stage II Follicular Mixed Cell Lymphoma|Contiguous Stage II Grade II Follicular Lymphoma|Contiguous Stage II Grade II Follicular Mixed Cell Lymphoma|Stage II Contiguous Follicular Mixed Cell Lymphoma
C8470	Stage_II_Grade_3_Contiguous_Follicular_Lymphoma	Stage_II_Grade_3_Follicular_Lymphoma	Stage II Grade 3 Contiguous Follicular Lymphoma|Contiguous Follicular Large Cell Lymphoma Stage II|Contiguous Grade III Follicular Large Cell Lymphoma Stage II|Contiguous Grade III Follicular Lymphoma Stage II|Contiguous Stage II Follicular Large Cell Lymphoma|Contiguous Stage II Grade III Follicular Large Cell Lymphoma|Contiguous Stage II Grade III Follicular Lymphoma|Stage II Contiguous Follicular Large Cell Lymphoma
C8471	Stage_II_Contiguous_Adult_Diffuse_Small_Cleaved_Cell_Lymphoma	Stage_II_Adult_Diffuse_Small_Cleaved_Cell_Lymphoma	Stage II Contiguous Adult Diffuse Small Cleaved Cell Lymphoma|Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma
C8472	Stage_II_Contiguous_Adult_Aggressive_Non-Hodgkin_s_Lymphoma	Aggressive_Adult_Non-Hodgkin_s_Lymphoma|Stage_II_Contiguous_Adult_Non-Hodgkin_s_Lymphoma	Stage II Contiguous Adult Aggressive Non-Hodgkin's Lymphoma|Adult Aggressive Contiguous Non-Hodgkin's Lymphoma Stage II|Adult Aggressive Contiguous Stage II Non-Hodgkin's Lymphoma|Aggressive Adult Contiguous Non-Hodgkins Lymphoma Stage II|Aggressive Adult Contiguous NonHodgkin's Lymphoma Stage II|Aggressive Adult Contiguous NonHodgkins Lymphoma Stage II|Aggressive Contiguous Adult Non-Hodgkin's Lymphoma Stage II|Aggressive Contiguous Stage II Adult Non-Hodgkin's Lymphoma|Stage II Aggressive Adult Contiguous Non-Hodgkin's Lymphoma|Stage II Aggressive Adult Contiguous Non-Hodgkins Lymphoma|Stage II Aggressive Adult Contiguous NonHodgkin's Lymphoma|Stage II Aggressive Adult Contiguous NonHodgkins Lymphoma
C8473	Stage_II_Contiguous_Mantle_Cell_Lymphoma	Stage_II_Mantle_Cell_Lymphoma	Stage II Contiguous Mantle Cell Lymphoma|Contiguous Mantle Cell Lymphoma Stage II|Contiguous Stage II Mantle Cell Lymphoma
C8474	Stage_II_Contiguous_Adult_Diffuse_Mixed_Cell_Lymphoma	Stage_II_Adult_Diffuse_Mixed_Cell_Lymphoma	Stage II Contiguous Adult Diffuse Mixed Cell Lymphoma|Contiguous Adult Diffuse Mixed Cell Lymphoma Stage II|Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma
C8475	Stage_II_Contiguous_Adult_Diffuse_Large_Cell_Lymphoma	Stage_II_Adult_Diffuse_Large_Cell_Lymphoma	Stage II Contiguous Adult Diffuse Large Cell Lymphoma|Contiguous Adult Diffuse Large Cell Lymphoma Stage II|Contiguous Stage II Adult Diffuse Large Cell Lymphoma
C8476	Stage_II_Contiguous_Adult_Lymphoblastic_Lymphoma	Stage_II_Adult_Lymphoblastic_Lymphoma|Stage_II_Contiguous_Adult_Non-Hodgkin_s_Lymphoma	Stage II Contiguous Adult Lymphoblastic Lymphoma|Adult Contiguous Lymphoblastic Lymphoma Stage II|Contiguous Adult Lymphoblastic Lymphoma Stage II|Contiguous Adult Stage II Lymphoblastic Lymphoma
C8477	Stage_II_Non-Contiguous_Adult_Non-Hodgkin_s_Lymphoma	Stage_II_Adult_Non-Hodgkin_s_Lymphoma	Stage II Non-Contiguous Adult Non-Hodgkin's Lymphoma|Adult Non-Contiguous Non-Hodgkin's Lymphoma Stage II|Adult Non-Contiguous Non-Hodgkins Lymphoma Stage II|Adult Non-Contiguous NonHodgkin's Lymphoma Stage II|Adult Non-Contiguous NonHodgkins Lymphoma Stage II|Adult Non-Contiguous Stage II Non-Hodgkin's Lymphoma|Adult NonContiguous Non-Hodgkin's Lymphoma Stage II|Adult NonContiguous Non-Hodgkins Lymphoma Stage II|Adult NonContiguous NonHodgkins Lymphoma Stage II|Non-Contiguous Adult Non-Hodgkin's Lymphoma Stage II|Non-Contiguous Stage II Adult Non-Hodgkin's Lymphoma|Stage II Adult Non-Contiguous Non-Hodgkin's Lymphoma|Stage II Adult Non-Contiguous Non-Hodgkins Lymphoma|Stage II Adult Non-Contiguous NonHodgkins Lymphoma|Stage II Adult NonContiguous Non-Hodgkin's Lymphoma|Stage II Adult NonContiguous Non-Hodgkins Lymphoma|Stage II Adult NonContiguous NonHodgkin's Lymphoma
C8478	Stage_II_Non-Contiguous_Adult_Indolent_Non-Hodgkin_s_Lymphoma	Indolent_Adult_Non-Hodgkin_s_Lymphoma|Stage_II_Non-Contiguous_Adult_Non-Hodgkin_s_Lymphoma	Stage II Non-Contiguous Adult Indolent Non-Hodgkin's Lymphoma|Adult Indolent Non-Contiguous Non-Hodgkin's Lymphoma Stage II|Adult Indolent Non-Contiguous Non-Hodgkins Lymphoma Stage II|Adult Indolent Non-Contiguous NonHodgkin's Lymphoma Stage II|Adult Indolent Non-Contiguous NonHodgkins Lymphoma Stage II|Adult Indolent Non-Contiguous Stage II Non-Hodgkin's Lymphoma|Adult Indolent NonContiguous Non-Hodgkin's Lymphoma Stage II|Adult Indolent NonContiguous NonHodgkin's Lymphoma Stage II|Adult Indolent NonContiguous NonHodgkins Lymphoma Stage II|Indolent Non-Contiguous Adult Non-Hodgkin's Lymphoma Stage II|Indolent Non-Contiguous Stage II Adult Non-Hodgkin's Lymphoma|Stage II Adult Indolent Non-Contiguous Non-Hodgkin's Lymphoma|Stage II Adult Indolent Non-Contiguous Non-Hodgkins Lymphoma|Stage II Adult Indolent Non-Contiguous NonHodgkin's Lymphoma|Stage II Adult Indolent Non-Contiguous NonHodgkins Lymphoma|Stage II Adult Indolent NonContiguous Non-Hodgkin's Lymphoma|Stage II Adult Indolent NonContiguous Non-Hodgkins Lymphoma|Stage II Adult Indolent NonContiguous NonHodgkin's Lymphoma|Stage II Adult Indolent NonContiguous NonHodgkins Lymphoma
C8479	Stage_II_Non-Contiguous_Aggressive_Adult_Non-Hodgkin_s_Lymphoma	Aggressive_Adult_Non-Hodgkin_s_Lymphoma|Stage_II_Non-Contiguous_Adult_Non-Hodgkin_s_Lymphoma	Stage II Non-Contiguous Aggressive Adult Non-Hodgkin's Lymphoma|Aggressive Non-Contiguous Adult Non-Hodgkin's Lymphoma Stage II|Aggressive Non-Contiguous Adult Non-Hodgkins Lymphoma Stage II|Aggressive Non-Contiguous Adult NonHodgkin's Lymphoma Stage II|Aggressive Non-Contiguous Adult NonHodgkins Lymphoma Stage II|Aggressive Non-Contiguous Stage II Adult Non-Hodgkin's Lymphoma|Aggressive NonContiguous Adult Non-Hodgkin's Lymphoma Stage II|Aggressive NonContiguous Adult Non-Hodgkins Lymphoma Stage II|Stage II Aggressive Non-Contiguous Adult Non-Hodgkin's Lymphoma|Stage II Aggressive Non-Contiguous Adult NonHodgkin's Lymphoma|Stage II Aggressive Non-Contiguous Adult NonHodgkins Lymphoma|Stage II Aggressive NonContiguous Adult Non-Hodgkin's Lymphoma|Stage II Aggressive NonContiguous Adult Non-Hodgkins Lymphoma|Stage II Aggressive NonContiguous Adult NonHodgkin's Lymphoma|Stage II Aggressive NonContiguous Adult NonHodgkins Lymphoma
C8480	Stage_II_Non-Contiguous_Adult_Diffuse_Large_Cell_Lymphoma	Stage_II_Adult_Diffuse_Large_Cell_Lymphoma	Stage II Non-Contiguous Adult Diffuse Large Cell Lymphoma|Non-Contiguous Adult Diffuse Large Cell Lymphoma Stage II|Non-Contiguous Stage II Adult Diffuse Large Cell Lymphoma|NonContiguous Adult Diffuse Large Cell Lymphoma Stage II|Stage II NonContiguous Adult Diffuse Large Cell Lymphoma
C8481	Stage_II_Non-Contiguous_Adult_Lymphoblastic_Lymphoma	Stage_II_Adult_Lymphoblastic_Lymphoma|Stage_II_Non-Contiguous_Adult_Non-Hodgkin_s_Lymphoma	Stage II Non-Contiguous Adult Lymphoblastic Lymphoma|Adult Non-Contiguous Lymphoblastic Lymphoma Stage II|Adult Non-Contiguous Stage II Lymphoblastic Lymphoma|Non-Contiguous Adult Lymphoblastic Lymphoma Stage II|Non-Contiguous Stage II Adult Lymphoblastic Lymphoma|NonContiguous Adult Lymphoblastic Lymphoma Stage II|Stage II Adult Non-Contiguous Lymphoblastic Lymphoma
C8482	Stage_III_Indolent_Adult_Non-Hodgkin_s_Lymphoma	Indolent_Adult_Non-Hodgkin_s_Lymphoma	Stage III Indolent Adult Non-Hodgkin's Lymphoma|Indolent Adult Non-Hodgkin's Lymphoma Stage III|Indolent Stage III Adult Non-Hodgkin's Lymphoma
C8483	Stage_III_Mantle_Cell_Lymphoma	Mantle_Cell_Lymphoma|Stage_III_B-Cell_Non-Hodgkin_s_Lymphoma	Stage III Mantle Cell Lymphoma|Mantle Cell Lymphoma Stage III	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C8484	Stage_III_Aggressive_Adult_Non-Hodgkin_s_Lymphoma	Aggressive_Adult_Non-Hodgkin_s_Lymphoma	Stage III Aggressive Adult Non-Hodgkin's Lymphoma|Aggressive Adult Non-Hodgkin's Lymphoma Stage III|Aggressive Stage III Adult Non-Hodgkin's Lymphoma
C8485	Stage_IV_Indolent_Adult_Non-Hodgkin_s_Lymphoma	Indolent_Adult_Non-Hodgkin_s_Lymphoma	Stage IV Indolent Adult Non-Hodgkin's Lymphoma|Indolent Adult Non-Hodgkin's Lymphoma Stage IV|Indolent Stage IV Adult Non-Hodgkin's Lymphoma
C8486	Stage_IV_Mantle_Cell_Lymphoma	Mantle_Cell_Lymphoma|Stage_IV_B-Cell_Non-Hodgkin_s_Lymphoma	Stage IV Mantle Cell Lymphoma|Mantle Cell Lymphoma Stage IV|Metastatic Mantle Cell Lymphoma	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8487	Stage_IV_Aggressive_Adult_Non-Hodgkin_s_Lymphoma	Aggressive_Adult_Non-Hodgkin_s_Lymphoma	Stage IV Aggressive Adult Non-Hodgkin's Lymphoma|Aggressive Adult Non-Hodgkin's Lymphoma Stage IV|Aggressive Stage IV Adult Non-Hodgkin's Lymphoma|Metastatic Aggressive Adult Non-Hodgkin's Lymphoma
C8488	Recurrent_Indolent_Adult_Non-Hodgkin_s_Lymphoma	Indolent_Adult_Non-Hodgkin_s_Lymphoma|Recurrent_Adult_Non-Hodgkin_s_Lymphoma	Recurrent Indolent Adult Non-Hodgkin's Lymphoma|Recurrent Adult Indolent Non-Hodgkin's Lymphoma
C8489	Recurrent_Mantle_Cell_Lymphoma	Mantle_Cell_Lymphoma|Recurrent_B-Cell_Non-Hodgkin_s_Lymphoma	Recurrent Mantle Cell Lymphoma
C8490	Recurrent_Aggressive_Adult_Non-Hodgkin_s_Lymphoma	Aggressive_Adult_Non-Hodgkin_s_Lymphoma|Recurrent_Adult_Non-Hodgkin_s_Lymphoma	Recurrent Aggressive Adult Non-Hodgkin's Lymphoma|Aggressive Recurrent Adult Non-Hodgkin's Lymphoma|Recurrent Adult Aggressive Non-Hodgkin's Lymphoma
C8491	Indolent_Adult_Non-Hodgkin_s_Lymphoma	Adult_Non-Hodgkin_s_Lymphoma|Indolent_Non-Hodgkin_s_Lymphoma	Indolent Adult Non-Hodgkin's Lymphoma|Adult Indolent Non-Hodgkin's Lymphoma
C8492	Aggressive_Adult_Non-Hodgkin_s_Lymphoma	Adult_Non-Hodgkin_s_Lymphoma|Aggressive_Non-Hodgkin_s_Lymphoma	Aggressive Adult Non-Hodgkin's Lymphoma|Adult Aggressive Non-Hodgkin's Lymphoma
C8493	Hereditary_Breast_and_Ovarian_Cancer_Syndrome	Hereditary_Neoplastic_Syndrome	Hereditary Breast and Ovarian Cancer Syndrome|Familial Breast/Ovarian Cancer (BRCA1, BRCA2)|Familiar Breast and Ovarian Cancer Syndrome|Hereditary Breast and Ovarian Cancer|Hereditary Breast/Ovarian Cancer (BRCA1, BRCA2)
C8494	Hereditary_Non-Polyposis_Colon_Cancer	Colon_Carcinoma|DNA_Repair_Disorder|Familial_Cancer	Hereditary Non-Polyposis Colon Cancer|Familial Non-Polyposis Colon Cancer (hMSH2, hMLH1, hPMS1, hPMS2)|HNPCC|Hereditary Colorectal Endometrial Cancer Syndrome|Hereditary Defective Mismatch Repair Syndrome|Hereditary Non-Polyposis Colon Cancer (hMSH2, hMLH1, hPMS1, hPMS2)|Hereditary Nonpolyposis Colon Cancer|Lynch Syndrome|Lynch syndrome|hereditary nonpolyposis colon cancer	An inherited disorder in which affected individuals have a higher-than-normal chance of developing colon cancer and certain other types of cancer, usually before the age of 60.
C8495	Hereditary_Retinoblastoma_RB1	Familial_Cancer|Retinoblastoma	Hereditary Retinoblastoma|Familial Retinoblastoma
C8496	Hereditary_Wilms_Tumor	Familial_Cancer|Renal_Wilms_Tumor	Hereditary Wilms' Tumor|Familial Wilms' Tumor|Familiar Wilms Tumor|Hereditary Kidney Adenosarcoma (WT1)|Hereditary Nephroblastoma (WT1)|Hereditary Renal Adenosarcoma (WT1)|Hereditary Wilms Tumor|Hereditary Wilms' Tumor (WT1)	1.  Familial embryonal neoplasm derived from nephrogenic blastemal cells.  Several lines of differentiation, including blastemal, stromal and epithelial, are usually expressed.  Comprises approximately 1% of Wilms' tumors.  (AFIP fascicle version 2.0 mo011000)
C8497	Neurofibromatosis_1_and_2_NF1_and_NF2	Neurofibromatosis	Neurofibromatosis 1 and 2 (NF1 and NF2)
C8498	Hereditary_Melanoma_1_and_2_CDKN2_CDK4	Familial_Cancer	Hereditary Melanoma|Familial Melanoma
C8499	Loss_Grief_and_Bereavement	Mental_and_Behavioral_Signs_and_Symptoms	Loss, Grief, and Bereavement
C8500	Bilateral_Carcinoma	Carcinoma	Bilateral Carcinoma|Bilateral Cancer|bilateral cancer	Cancer that occurs in both paired organs, such as both breasts or both ovaries.
C8501	Brain_Stem_Glioma	Brain_Stem_Neoplasm|Neuroglial_Tumor	Brain Stem Glioma|Brain Stem Neuroglial Neoplasm|Brain Stem Neuroglial Tumor|Brainstem Glioma|Brainstem Neuroglial Neoplasm|Brainstem Neuroglial Tumor|Glioma of Brain Stem|Glioma of Brainstem|Glioma of the Brain Stem|Glioma of the Brainstem|brain stem glioma	(glee-O-ma) A tumor located in the part of the brain that connects to the spinal cord (the brain stem). It may grow rapidly or slowly, depending on the grade of the tumor.
C8502	chronic_lymphoblastic_lymphoma	Leukemia_Antiquated	Chronic Lymphoblastic Lymphoma|chronic lymphoblastic lymphoma	A slowly progressing disease in which too many immature white blood cells (called lymphoblasts) are found in the body.
C8503	Evaluable_Disease	Clinical_Course_of_Disease	Evaluable Disease|EVAL|Evaluable|evaluable disease	Disease that cannot be measured directly by the size of the tumor but can be evaluated by other methods specific to a particular clinical trial.
C8504	Indolent_Non-Hodgkin_s_Lymphoma	Non-Hodgkin_s_Lymphoma_by_Clinical_Course	Indolent Non-Hodgkin's Lymphoma|indolent lymphoma	Lymphomas that tend to grow and spread slowly, including chronic lymphocytic lymphoma and follicular small cleaved cell lymphoma. Also called low-grade lymphomas.
C8505	Invasive_Malignant_Neoplasm	Malignant_Neoplasm	Invasive Malignant Neoplasm|Infiltrating Malignant Neoplasm|infiltrating cancer|invasive cancer	Cancer that has spread beyond the layer of tissue in which it developed and is growing into surrounding, healthy tissues.
C8506	Malignant_Leptomeningeal_Neoplasm	Leptomeningeal_Neoplasm|Malignant_Neoplasms_of_the_Meninges	Malignant Leptomeningeal Neoplasm|Malignant Leptomeningeal Tumor|Malignant Neoplasm of Leptomeninges|Malignant Neoplasm of the Leptomeninges|Malignant Tumor of Leptomeninges|Malignant Tumor of the Leptomeninges|leptomeningeal cancer	A primary or metastatic malignant tumor involving the leptomeninges.
C8507	Measurable_Disease	Clinical_Course_of_Disease	Measurable Disease|measurable disease	A tumor that can be accurately measured in size. This information can be used to judge response to treatment.
C8508	Positive_Axillary_Lymph_Node	Positive_Lymph_Node	Positive Axillary Lymph Node|positive axillary lymph nodes	Lymph nodes in the area of the armpit (axilla) to which cancer has spread. This spread is determined by surgically removing some of the lymph nodes and examining them under a microscope to see whether cancer cells are present.
C8509	Primary_Neoplasm	Neoplasm_by_Special_Category	Primary Neoplasm|Primary Tumor|primary tumor	The original tumor.
C8510	Progressive_Neoplastic_Disease	Progressive_Disease	Progressive Neoplastic Disease	Cancer that is increasing in scope or severity.
C8511	Refractory_Carcinoma	Carcinoma	Refractory Carcinoma|Refractory Cancer|refractory cancer	Cancer that has not responded to treatment.
C8512	Cancer_with_Regional_Lymph_Node_Involvement	Locally_Metastatic_Neoplasm	Cancer with Regional Lymph Node Involvement
C8513	Stage_I_Colorectal_Cancer	Colorectal_Carcinoma	Stage I Colorectal Cancer|Colorectal Cancer, Stage I|Dukes A Colorectal Carcinoma|Stage I Colorectal Carcinoma|stage I colorectal cancer	Stage I includes: T1, T2 and NO, MO.  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis (AJCC 6th ed.)-2003
C8514	Stage_II_Colorectal_Cancer	Colorectal_Carcinoma	Stage II Colorectal Cancer|Colorectal Cancer, Stage II|Colorectal Carcinoma Stage II|Dukes B Colorectal Carcinoma|Stage II Colorectal Carcinoma|stage II colorectal cancer	Cancer that has spread beyond the colon/rectum but not to the lymph nodes. Also called Dukes B colorectal cancer.
C8515	Stage_III_Colorectal_Cancer	Colorectal_Carcinoma	Stage III Colorectal Cancer|Colorectal Cancer, Stage III|Dukes C Colorectal Carcinoma|Stage III Colorectal Carcinoma|stage III colorectal cancer	Stage Group III is subdivided into IIIA (T1-2, N1, M0), IIIB (T3-4, N1, M0) or IIIC (any T, N2 M0).  T1: Tumor invades the submucosa.  T2: Tumor invades muscularis propria.  T3: Tumor invades through the muscularis propria into the subserosa or into non-peritonealized pericolic or perirectal tissues.  T4: Tumor directly invades other organs or structures, and/or perforates visceral peritoneum.  N1: Metastasis in 1 to 3 regional lymph nodes N2: Metastasis in 4 or more regional lymph nodes.  M0: No distant metastasis.  (AJCC 6th ed.) - 2003
C8516	Stage_IV_Colorectal_Cancer	Colorectal_Carcinoma	Stage IV Colorectal Cancer|Astler-Coller D Colorectal Cancer|Colorectal Cancer, Stage IV|Colorectal Carcinoma Stage IV|Dukes D Colorectal Carcinoma|Stage IV Colorectal Carcinoma|stage IV colorectal cancer	Cancer cells have spread to organs and lymph nodes in other parts of the body.
C8517	Stage_I_Hodgkin_s_Lymphoma	Hodgkin_s_Lymphoma|Stage_I_Lymphoma	Stage I Hodgkin's Lymphoma|Hodgkin's Disease Stage I|Hodgkin's Lymphoma Stage I|Stage I Hodgkin Lymphoma|Stage I Hodgkin's Disease|Stage I Hodgkins Disease|Stage I Hodgkins Lymphoma|stage I Hodgkin's disease	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C8518	Stage_II_Hodgkin_s_Lymphoma	Hodgkin_s_Lymphoma|Stage_II_Lymphoma	Stage II Hodgkin's Lymphoma|Hodgkin's Disease Stage II|Hodgkin's Lymphoma Stage II|Stage II Hodgkin Lymphoma|Stage II Hodgkin's Disease|Stage II Hodgkins Disease|Stage II Hodgkins Lymphoma|stage II Hodgkin's disease	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C8519	Stage_IV_Hodgkin_s_Lymphoma	Hodgkin_s_Lymphoma|Stage_IV_Lymphoma	Stage IV Hodgkin's Lymphoma|Hodgkin's Disease Stage IV|Hodgkin's Lymphoma Stage IV|Metastatic Hodgkin's Lymphoma|Stage IV Hodgkin's Disease|Stage IV Hodgkins Disease|Stage IV Hodgkins Lymphoma|stage IV Hodgkin's disease	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8520	Stage_I_Non-Hodgkin_s_Lymphoma	Non-Hodgkin_s_Lymphoma|Stage_I_Lymphoma	Stage I Non-Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma Stage I|Non-Hodgkins Lymphoma Stage I|NonHodgkin's Lymphoma Stage I|Stage I Non-Hodgkins Lymphoma|Stage I NonHodgkin's Lymphoma|Stage I NonHodgkins Lymphoma|stage I non-Hodgkin's lymphoma	Cancer found in only one lymph node area or one area or organ outside the lymph nodes.
C8521	Stage_II_Non-Hodgkin_s_Lymphoma	Non-Hodgkin_s_Lymphoma|Stage_II_Lymphoma	Stage II Non-Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma Stage II|NonHodgkin's Lymphoma Stage II|NonHodgkins Lymphoma Stage II|Stage II Non-Hodgkins Lymphoma|Stage II NonHodgkins Lymphoma|stage II non-Hodgkin's lymphoma	Cancer that is found in two or more lymph node areas on the same side of the diaphragm (the muscle under the lungs that helps breathing). Cancer is found in only one area or organ outside the lymph nodes and in the lymph nodes around it. Other lymph node areas on the same side of the diaphragm may also have cancer.
C8522	Stage_III_Non-Hodgkin_s_Lymphoma	Non-Hodgkin_s_Lymphoma|Stage_III_Lymphoma	Stage III Non-Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma Stage III|Non-Hodgkins Lymphoma Stage III|NonHodgkin's Lymphoma Stage III|NonHodgkins Lymphoma Stage III|Stage III Non-Hodgkins Lymphoma|Stage III NonHodgkin's Lymphoma|Stage III NonHodgkins Lymphoma|stage III non-Hodgkin's lymphoma	Cancer is found in lymph node areas on both sides of the diaphragm. The cancer may also have spread to an area or organ near the lymph node areas, to the spleen, or both.
C8523	Stage_IV_Non-Hodgkin_s_Lymphoma	Stage_IV_Lymphoma	Stage IV Non-Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma Stage IV|Non-Hodgkins Lymphoma Stage IV|NonHodgkin's Lymphoma Stage IV|NonHodgkins Lymphoma Stage IV|Stage IV Non-Hodgkins Lymphoma|Stage IV NonHodgkin's Lymphoma|Stage IV NonHodgkins Lymphoma|stage IV non-Hodgkin's lymphoma	Cancer has spread to more than one organ or organs outside the lymph system. Cancer cells may be found in the lymph nodes near these organs. Cancer has spread to only one organ outside the lymph system, but lymph nodes far away from that organ are involved.
C8524	Locally_Advanced_Malignant_Neoplasm	Advanced_Malignant_Neoplasm	Locally Advanced Malignant Neoplasm|LOC|Locally|Locally Advanced Cancer|locally advanced cancer	Cancer that has spread only to nearby tissues or lymph nodes.
C8525	Benign_Sebaceous_Neoplasm	Benign_Skin_Appendage_Neoplasm|Sebaceous_Neoplasm	Benign Sebaceous Neoplasm|Benign Neoplasm of Sebaceous Gland|Benign Neoplasm of the Sebaceous Gland|Benign Sebaceous Gland Neoplasm|Benign Sebaceous Gland Tumor|Benign Sebaceous Skin Neoplasm|Benign Sebaceous Skin Tumor|Benign Sebaceous Tumor|Benign Tumor of Sebaceous Gland|Benign Tumor of the Sebaceous Gland
C8527	Metastasis_to_the_Sternum	Malignant_Sternal_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Sternum|Metastasis to the Sternum|Metastatic Malignant Tumor to the Sternum|Metastatic Neoplasm to the Sternum|Metastatic Tumor to the Sternum
C8528	Metastatic_Neoplasm_to_the_Neck	Malignant_Neck_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Neck|Metastases to Neck|Metastasis to the Neck|Metastatic Neoplasm to the Neck|Metastatic Tumor to the Neck	The spread of cancer to the neck.  This may be from a primary cancer of the neck, or from a cancer at a distant site.
C8529	Benign_Chest_Wall_Neoplasm	Benign_Thoracic_Neoplasm|Chest_Wall_Neoplasm	Benign Chest Wall Neoplasm|Benign Chest Wall Tumor|Benign Neoplasm of Chest Wall|Benign Neoplasm of the Chest Wall|Benign Tumor of Chest Wall|Benign Tumor of the Chest Wall
C8530	Metastasis_to_the_Chest_Wall	Malignant_Chest_Wall_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Chest Wall|Metastasis to the Chest Wall|Metastatic Neoplasm to the Chest Wall|Metastatic Tumor to the Chest Wall|Secondary Malignant Neoplasm to the Chest Wall|Secondary Malignant Tumor to the Chest Wall
C8531	Benign_Respiratory_Tract_Neoplasm	Respiratory_Tract_Neoplasm	Benign Respiratory Tract Neoplasm|Benign Neoplasm of Respiratory Tract|Benign Neoplasm of the Respiratory Tract|Benign Respiratory Tract Tumor|Benign Tumor of Respiratory Tract|Benign Tumor of the Respiratory Tract
C8532	Benign_Paranasal_Sinus_Neoplasm	Paranasal_Sinus_Neoplasm	Benign Paranasal Sinus Neoplasm|Benign Accessory Sinus Neoplasm|Benign Accessory Sinus Tumor|Benign Nasal Sinus Neoplasm|Benign Nasal Sinus Tumor|Benign Neoplasm of Accessory Sinus|Benign Neoplasm of Nasal Sinus|Benign Neoplasm of Paranasal Sinus|Benign Neoplasm of the Accessory Sinus|Benign Neoplasm of the Nasal Sinus|Benign Neoplasm of the Paranasal Sinus|Benign Paranasal Sinus Tumor|Benign Tumor of Accessory Sinus|Benign Tumor of Nasal Sinus|Benign Tumor of Paranasal Sinus|Benign Tumor of the Accessory Sinus|Benign Tumor of the Nasal Sinus|Benign Tumor of the Paranasal Sinus
C8533	Stage_IV_Hypopharyngeal_Carcinoma	Hypopharyngeal_Carcinoma	Stage IV Hypopharyngeal Carcinoma|Stage IV Carcinoma of Hypopharynx|Stage IV Carcinoma of the Hypopharynx|Stage IV Hypopharynx Carcinoma|stage IV hypopharynx cancer	The tumor has spread to nearby tissues and lymph nodes of the neck and may have spread to other parts of the body.
C8535	Benign_Epicardial_Neoplasm	Benign_Cardiac_Neoplasm|Epicardial_Neoplasm	Benign Epicardial Neoplasm|Benign Epicardial Tumor|Benign Neoplasm of Epicardium|Benign Neoplasm of the Epicardium|Benign Tumor of Epicardium|Benign Tumor of the Epicardium
C8536	Benign_Pericardial_Neoplasm	Benign_Cardiac_Neoplasm|Pericardial_Neoplasm	Benign Pericardial Neoplasm|Benign Neoplasm of Pericardium|Benign Neoplasm of the Pericardium|Benign Pericardial Tumor|Benign Tumor of Pericardium|Benign Tumor of the Pericardium
C8537	Benign_Blood_Vessel_Neoplasm	Benign_Vascular_Neoplasm|Blood_Vessel_Neoplasm	Benign Blood Vessel Neoplasm|Benign Blood Vessel Tumor
C8538	Malignant_Blood_Vessel_Neoplasm	Blood_Vessel_Neoplasm|Malignant_Vascular_Neoplasm	Malignant Blood Vessel Neoplasm|Malignant Blood Vessel Tumor
C8539	Benign_Great_Vessel_Neoplasm	Great_Vessel_Neoplasm	Benign Great Vessel Neoplasm|Benign Great Vessel Tumor|Benign Neoplasm of Great Vessel|Benign Neoplasm of the Great Vessel|Benign Tumor of Great Vessel|Benign Tumor of the Great Vessel
C8540	Subcutaneous_Tissue_Hemangioma	Hemangioma	Subcutaneous Tissue Hemangioma|Angioma of Subcutaneous Tissue|Angioma of the Subcutaneous Tissue|Hemangioma of Subcutaneous Tissue|Hemangioma of the Subcutaneous Tissue|Subcutaneous Angioma|Subcutaneous Hemangioma|Subcutaneous Tissue Angioma
C8541	Splenic_Hemangioma	Benign_Splenic_Neoplasm|Intra-Abdominal_Hemangioma	Splenic Hemangioma|Angioma of Spleen|Angioma of the Spleen|Hemangioma of Spleen|Hemangioma of the Spleen|Spleen Angioma|Spleen Hemangioma|Splenic Angioma
C8542	Metastatic_Neoplasm_to_the_Lip	Malignant_Lip_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Lip|Metastasis to the Lip|Metastatic Neoplasm to the Lip|Metastatic Tumor to the Lip
C8543	Metastatic_Neoplasm_to_the_Pancreas	Malignant_Pancreatic_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Pancreas|Metastatic Cancer to the Pancreas|Metastatic Neoplasm to the Pancreas|Metastatic Tumor to the Pancreas|Secondary Cancer to the Pancreas|Secondary Malignant Neoplasm to the Pancreas|Secondary Malignant Tumor to the Pancreas
C8544	Metastatic_Neoplasm_to_the_Epididymis	Malignant_Epididymal_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Epididymis|Metastatic Neoplasm to the Epididymis|Metastatic Tumor to the Epididymis
C8545	Benign_Placental_Neoplasm	Placental_Neoplasm	Benign Placental Neoplasm|Benign Neoplasm of Placenta|Benign Neoplasm of the Placenta|Benign Placenta Neoplasm|Benign Placenta Tumor|Benign Placental Tumor|Benign Tumor of Placenta|Benign Tumor of the Placenta|Placental Neoplasms, Benign
C8546	Metastatic_Neoplasm_to_the_Placenta	Malignant_Placental_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Placenta|Metastasis to Placenta|Metastasis to the Placenta|Metastatic Neoplasm to the Placenta|Metastatic Tumor to the Placenta
C8547	Metastasis_to_the_Nervous_System	Malignant_Nervous_System_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Nervous System|Metastases to Nervous System|Metastasis to the Nervous System|Metastatic Neoplasm to the Nervous System|Metastatic Tumor to the Nervous System|Secondary Malignant Neoplasm to the Nervous System|Secondary Malignant Tumor to the Nervous System	The spread of the cancer to the nervous system.  This may be from a primary nervous system cancer, or from a cancer at a distant site.
C8548	Benign_Cerebral_Neoplasm	Benign_Supratentorial_Neoplasm|Cerebral_Neoplasm	Benign Cerebral Neoplasm|Benign Cerebral Hemispheric Neoplasm|Benign Cerebral Hemispheric Tumor|Benign Cerebral Tumor|Benign Neoplasm of Cerebral Hemispheres|Benign Neoplasm of Cerebrum|Benign Neoplasm of the Cerebral Hemispheres|Benign Neoplasm of the Cerebrum|Benign Tumor of Cerebral Hemispheres|Benign Tumor of Cerebrum|Benign Tumor of the Cerebral Hemispheres|Benign Tumor of the Cerebrum
C8549	Benign_Brain_Stem_Neoplasm	Benign_Infratentorial_Neoplasm|Brain_Stem_Neoplasm	Benign Brain Stem Neoplasm|Benign Brain Stem Neoplasms|Benign Brain Stem Tumor|Benign Brainstem Neoplasm|Benign Brainstem Neoplasms|Benign Brainstem Tumor|Benign Brainstem Tumors|Benign Neoplasm of Brain Stem|Benign Neoplasm of Brainstem|Benign Neoplasm of the Brain Stem|Benign Neoplasm of the Brainstem|Benign Neoplasms of Brainstem|Benign Neoplasms of the Brainstem|Benign Tumor of Brain Stem|Benign Tumor of Brainstem|Benign Tumor of the Brain Stem|Benign Tumor of the Brainstem|Benign Tumors of Brainstem|Benign Tumors of the Brainstem
C8550	Metastatic_Neoplasm_to_the_Brain_Stem	Malignant_Brain_Stem_Neoplasm|Metastatic_Neoplasm_to_the_Brain	Metastatic Malignant Neoplasm to the Brain Stem|Metastatic Neoplasm to the Brain Stem|Metastatic Neoplasm to the Brainstem|Metastatic Tumor to the Brain Stem|Metastatic Tumor to the Brainstem
C8553	Metastasis_to_the_Ciliary_Body	Malignant_Ciliary_Body_Neoplasm|Metastatic_Neoplasm_to_the_Eye	Metastatic Malignant Neoplasm to the Ciliary Body|Metastasis to the Ciliary Body|Metastatic Neoplasm to the Ciliary Body|Metastatic Tumor to the Ciliary Body
C8554	Metastatic_Neoplasm_to_the_Choroid	Malignant_Choroid_Neoplasm|Metastatic_Neoplasm_to_the_Eye	Metastatic Malignant Neoplasm to the Choroid|Metastatic Neoplasm to the Choroid|Metastatic Tumor to the Choroid
C8555	Metastatic_Neoplasm_to_the_Retina	Malignant_Retinal_Neoplasm|Metastatic_Neoplasm_to_the_Eye	Metastatic Malignant Neoplasm to the Retina|Metastasis to the Retina|Metastatic Neoplasm to the Retina|Metastatic Tumor to the Retina
C8556	Metastatic_Neoplasm_to_the_Orbit	Malignant_Orbit_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Orbit|Metastasis to the Orbit|Metastatic Neoplasm to the Orbit|Metastatic Tumor to the Orbit
C8557	Metastatic_Neoplasm_to_the_Parathyroid	Malignant_Parathyroid_Neoplasm|Metastatic_Neoplasm_to_the_Neck	Metastatic Malignant Neoplasm to the Parathyroid Gland|Metastasis to the Parathyroid Gland|Metastatic Neoplasm to the Parathyroid|Metastatic Neoplasm to the Parathyroid Gland|Metastatic Tumor to the Parathyroid|Metastatic Tumor to the Parathyroid Gland	A malignant neoplasm either directly extending to the parathyroid glands from adjacent anatomic structures, or spreading to the parathyroid glands from distant anatomic sites, most frequently breast, lung, kidney, soft tissues, and skin. (NCI05)
C8559	Malignant_Paraganglionic_Neoplasm	Malignant_Endocrine_Neoplasm|Paraganglionic_Neoplasm	Malignant Paraganglioma|Malignant Neoplasm of Paraganglion|Malignant Neoplasm of the Paraganglion|Malignant Paraganglion Neoplasm|Malignant Paraganglion Tumor|Malignant Paraganglionic Neoplasm|Malignant Paraganglionic Tumor|Malignant Tumor of Paraganglion|Malignant Tumor of the Paraganglion|Paraganglion Neoplasm, Malignant	A paraganglioma that metastasizes to regional or distant anatomic sites.  Extraadrenal paragangliomas have a higher tendency to metastasize, as compared to pheochromocytomas.  Common sites of metastasis include the lymph nodes, lungs, bones, and liver.
C8560	Erythroleukemia_in_Remission	Acute_Erythroid_Leukemia_in_Remission	Erythroleukemia in Remission	Erythroleukemia that is responding to therapy, i.e. It is not progressing and possibly regressing
C8561	Malignant_Male_Reproductive_System_Neoplasm	Male_Reproductive_System_Neoplasm|Malignant_Reproductive_System_Neoplasm	Malignant Male Reproductive System Neoplasm|Malignant Male Reproductive System Tumor|Malignant Neoplasm of Male Reproductive System|Malignant Neoplasm of the Male Reproductive System|Malignant Tumor of Male Reproductive System|Malignant Tumor of the Male Reproductive System	A primary or metastatic malignant tumor involving the male reproductive system. -- 2003
C8562	Ocular_Melanoma	Eye_Neoplasm|Melanoma	Ocular Melanoma|Eye Melanoma|Melanoma of Eye|Melanoma of the Eye|ocular melanoma	A rare cancer of melanocytes (cells that produce thepigment melanin) found in the eye.  Also called intraocular melanoma.
C8563	Malignant_Bone_Fibrous_Histiocytoma	Bone_Sarcoma|Malignant_Fibrous_Histiocytoma	Malignant Bone Fibrous Histiocytoma|Malignant Fibrous Histiocytoma of Bone|Malignant Fibrous Histiocytoma of the Bone
C8564	Stage_II_Adult_Contiguous_Immunoblastic_Lymphoma	Stage_II_Adult_Immunoblastic_Lymphoma|Stage_II_Contiguous_Adult_Non-Hodgkin_s_Lymphoma	Stage II Adult Contiguous Immunoblastic Lymphoma|Contiguous Adult Immunoblastic Large Cell Lymphoma Stage II|Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma|Stage II Contiguous Adult Immunoblastic Large Cell Lymphoma
C8565	Stage_II_Adult_Non-Contiguous_Immunoblastic_Lymphoma	Stage_II_Adult_Immunoblastic_Lymphoma|Stage_II_Non-Contiguous_Adult_Non-Hodgkin_s_Lymphoma	Stage II Adult Non-Contiguous Immunoblastic Lymphoma|Non-Contiguous Adult Immunoblastic Large Cell Lymphoma Stage II|Non-Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma|NonContiguous Adult Immunoblastic Large Cell Lymphoma Stage II|Stage II Non-Contiguous Adult Immunoblastic Large Cell Lymphoma|Stage II NonContiguous Adult Immunoblastic Large Cell Lymphoma
C8566	Metastatic_Neoplasm_of_Unknown_Primary_Origin	Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm of Unknown Primary Origin|Cancer of Unknown Primary Site|Metastatic Malignant Neoplasm of Unknown Primary|Metastatic Neoplasm of Unknown Primary Origin|cancer of unknown primary origin	A case in which cancer cells are found in the body, but the place where the cells first started growing (the origin or primary site) cannot be determined.
C8567	Visual_Pathway_Glioma	Neuroglial_Tumor|Visual_Pathway_Neoplasm	Visual Pathway Glioma|Glioma of Optic Tract|Glioma of Visual Pathway|Glioma of the Optic Tract|Glioma of the Visual Pathway|Optic Tract Glioma|visual pathway glioma	A rare, slow-growing tumor of the eye.
C8568	Adult_Choroid_Plexus_Neoplasm	Adult_Brain_Neoplasm|Choroid_Plexus_Neoplasm	Adult Choroid Plexus Neoplasm|Adult Choroid Plexus Tumor|Neoplasm of Adult Choroid Plexus|Neoplasm of the Adult Choroid Plexus|Tumor of Adult Choroid Plexus|Tumor of the Adult Choroid Plexus
C8569	Stage_IA_Adult_Soft_Tissue_Sarcoma	Stage_IA_Soft_Tissue_Sarcoma|Stage_I_Adult_Soft_Tissue_Sarcoma	Stage IA Adult Soft Tissue Sarcoma|Stage IA Adult Sarcoma of Soft Tissue|Stage IA Adult Sarcoma of the Soft Tissue
C8570	Stage_IB_Adult_Soft_Tissue_Sarcoma	Stage_IB_Soft_Tissue_Sarcoma|Stage_I_Adult_Soft_Tissue_Sarcoma	Stage IB Adult Soft Tissue Sarcoma|Stage IB Adult Sarcoma of Soft Tissue|Stage IB Adult Sarcoma of the Soft Tissue
C8571	Stage_IIA_Adult_Soft_Tissue_Sarcoma	Stage_IIA_Soft_Tissue_Sarcoma|Stage_II_Adult_Soft_Tissue_Sarcoma	Stage IIA Adult Soft Tissue Sarcoma|Stage IIA Adult Sarcoma of Soft Tissue|Stage IIA Adult Sarcoma of the Soft Tissue
C8572	Stage_IIB_Adult_Soft_Tissue_Sarcoma	Stage_IIB_Soft_Tissue_Sarcoma|Stage_II_Adult_Soft_Tissue_Sarcoma	Stage IIB Adult Soft Tissue Sarcoma|Stage IIB Adult Sarcoma of Soft Tissue|Stage IIB Adult Sarcoma of the Soft Tissue
C8573	Stage_IIC_Adult_Soft_Tissue_Sarcoma	Stage_IIC_Soft_Tissue_Sarcoma|Stage_II_Adult_Soft_Tissue_Sarcoma	Stage IIC Adult Soft Tissue Sarcoma|Stage IIC Adult Sarcoma of Soft Tissue|Stage IIC Adult Sarcoma of the Soft Tissue
C8574	Refractory_Cytopenia_with_Multilineage_Dysplasia	Myelodysplastic_Syndrome	Refractory Cytopenia with Multilineage Dysplasia|RCMD	A myelodysplastic syndrome characterized by bi-cytopenia or pancytopenia and dysplastic changes in 10% or more of the cells in two or more of the myeloid cell lines.  A minority of cases progress to acute myeloid leukemia.  (WHO, 2001) -- 2003
C8575	Stage_IVB_Pancreatic_Cancer	Stage_IV_Pancreatic_Cancer	Stage IVB Pancreatic Cancer|Metastatic Carcinoma of Pancreas|Metastatic Carcinoma of the Pancreas|Metastatic Pancreas Carcinoma|Metastatic Pancreatic Carcinoma|Pancreatic Cancer Stage IVB|Pancreatic Carcinoma, Metastatic|Stage IVB Carcinoma of Pancreas|Stage IVB Carcinoma of the Pancreas|Stage IVB Pancreatic Carcinoma|stage IVB pancreatic cancer	Cancer of the pancreas in which the cancer has spread to distant organs (such as the liver or lungs).
C8576	Localized_Malignant_Neoplasm	Malignant_Neoplasm	Localized Malignant Neoplasm|Local Cancer|Localized Cancer|Localized Malignancy|local cancer	A malignant neoplasm which is confined to a specific anatomic site and has not been spread. -- 2003
C8577	Infiltrating_Cervical_Carcinoma	Cervical_Carcinoma	Infiltrating Cervical Carcinoma|Cervical Dsyplasia|SY|NCI|invasive cervical cancer	Cancer that has spread from the surface of the cervix to tissue deeper in the cervix or to other parts of the body.
C8578	Childhood_Ependymoma	Childhood_Central_Nervous_System_Neoplasm|Ependymoma	Childhood Ependymoma|Pediatric Ependymoma
C8579	Recurrent_Childhood_Ependymoma	Childhood_Ependymoma|Recurrent_Childhood_Central_Nervous_System_Neoplasm	Recurrent Childhood Ependymoma|Recurrent Pediatric Ependymoma|Relapsed Childhood Ependymoma|Relapsed Pediatric Ependymoma
C8580	Stage_IB_Soft_Tissue_Sarcoma	Stage_I_Soft_Tissue_Sarcoma	Stage IB Soft Tissue Sarcoma|Stage IB Sarcoma of Soft Tissue|Stage IB Sarcoma of the Soft Tissue|stage IB soft tissue sarcoma	Cancer in which the cells look somewhat different from normal cells. The cancer is larger than 5 centimeters (about 2 inches) and has not spread to lymph nodes or other parts of the body.
C8581	Stage_IIA_Soft_Tissue_Sarcoma	Stage_II_Soft_Tissue_Sarcoma	Stage IIA Soft Tissue Sarcoma|Stage IIA Sarcoma of Soft Tissue|Stage IIA Sarcoma of the Soft Tissue|stage IIA soft tissue sarcoma	The cancer cells look somewhat different from normal cells. The cancer is larger than 5 centimeters (about 2 inches) and has not spread to lymph nodes or other parts of the body.
C8582	Stage_IIB_Soft_Tissue_Sarcoma	Stage_II_Soft_Tissue_Sarcoma	Stage IIB Soft Tissue Sarcoma|Stage IIB Sarcoma of Soft Tissue|Stage IIB Sarcoma of the Soft Tissue|stage IIB soft tissue sarcoma	The cancer cells look very different from normal cells. The cancer is smaller than 5 centimeters (about 2 inches) and has not spread to lymph nodes or other parts of the body.
C8583	Stage_IA_Soft_Tissue_Sarcoma	Stage_I_Soft_Tissue_Sarcoma	Stage IA Soft Tissue Sarcoma|Stage IA Sarcoma of Soft Tissue|Stage IA Sarcoma of the Soft Tissue|stage IA soft tissue sarcoma	Cancer in which the cells look very much like normal cells. The cancer is smaller than 5 centimeters (about 2 inches) and has not spread to lymph nodes or other parts of the body.
C8584	Stage_IIC_Soft_Tissue_Sarcoma	Stage_II_Soft_Tissue_Sarcoma	Stage IIC Soft Tissue Sarcoma|Stage IIC Sarcoma of Soft Tissue|Stage IIC Sarcoma of the Soft Tissue|stage IIC soft tissue sarcoma	The cancer cells look very different from normal cells. The cancer is larger than 5 centimeters (about 2 inches) and has not spread to lymph nodes or other parts of the body.
C8585	Stage_III_Soft_Tissue_Sarcoma	Soft_Tissue_Sarcoma	Stage III Soft Tissue Sarcoma|Stage III Sarcoma of Soft Tissue|Stage III Sarcoma of the Soft Tissue|stage III soft tissue sarcoma	The cancer cells look very different from normal cells. The cancer is larger than 5 centimeters (about 2 inches) but has not spread to lymph nodes or other parts of the body.
C8586	Stage_IV_Soft_Tissue_Sarcoma	Soft_Tissue_Sarcoma	Stage IV Soft Tissue Sarcoma|Stage IV Sarcoma of Soft Tissue|Stage IV Sarcoma of the Soft Tissue|stage IV soft tissue sarcoma	The cancer has spread to lymph nodes in the area or other parts of the body (such as the lungs, head, or neck).
C8587	Precancerous_Polyp	Neoplastic_Polyp	Precancerous Polyp|precancerous polyps	Growths that protrude from a mucous membrane. Precancerous polyps may (or are likely to) become cancer.
C8588	Childhood_Ovarian_Germ_Cell_Tumor	Childhood_Germ_Cell_Neoplasm|Ovarian_Germ_Cell_Tumor	Childhood Ovarian Germ Cell Tumor|Childhood Ovarian Germ Cell Neoplasm|Pediatric Ovarian Germ Cell Neoplasm|Pediatric Ovarian Germ Cell Tumor
C8589	Acute_Myelomonocytic_Leukemia_in_Remission	Acute_Myeloid_Leukemia_in_Remission	Acute Myelomonocytic Leukemia in Remission
C8590	Lymphocyte_Predominant_Type_Hodgkin_s_Disease	Hodgkin_s_Lymphoma_Antiquated	Lymphocyte Predominant Type Hodgkin's Disease
C8591	Testicular_Germ_Cell_Neoplasm	Germ_Cell_Neoplasm|Reproductive_Endocrine_Neoplasm|Testicular_Neoplasm	Testicular Germ Cell Tumor|Germ Cell Neoplasm of Testis|Germ Cell Neoplasm of the Testis|Germ Cell Tumor of Testis|Germ Cell Tumor of the Testis|Testicular Germ Cell Neoplasm|Testicular Germ Cell Neoplasms
C8592	Benign_Chondrogenic_Neoplasm	Benign_Mesenchymal_Cell_Neoplasm|Chondrogenic_Neoplasm	Benign Chondrogenic Neoplasm|Benign Cartilaginous Neoplasm|Benign Cartilaginous Tumor|Benign Chondrogenic Tumor|Benign Neoplasm of Cartilage|Benign Neoplasm of the Cartilage|Benign Tumor of Cartilage|Benign Tumor of the Cartilage
C8594	Leukemic_Phase_of_Lymphoma	Lymphoid_Leukemia|Non-Hodgkin_s_Lymphoma	Leukemic Phase of Lymphoma|Leukemic Lymphoma|Leukemic Phase of Non-Hodgkin's Lymphoma	A usually terminal event in the clinical course of lymphomas.  The term indicates the presence of atypical, clonal (malignant) lymphocytes (lymphoma cells) in the peripheral blood. --2003
C8595	Postcricoid_Carcinoma	Hypopharyngeal_Carcinoma|Malignant_Postcricoid_Neoplasm	Postcricoid Carcinoma|Cancer of Postcricoid Area|Cancer of the Postcricoid Area|Postcricoid Cancer
C8596	Vulvar_Angiokeratoma	Angiokeratoma	Vulvar Angiokeratoma
C8597	Retro-Orbit_Neoplasm	Skull_Neoplasm	Retro-Orbit Neoplasm|Neoplasm of Retro-Orbit|Neoplasm of the Retro-Orbit|Retro-Orbit Tumor|Retro-Orbital Neoplasm|Retro-Orbital Tumor|Tumor of Retro-Orbit|Tumor of the Retro-Orbit	Abnormal growth of the cells behind the orbit
C8598	Aggravated_Epilepsy	Epilepsy	Aggravated Epilepsy
C8600	Stage_II_Extragonadal_Primary_Mixed_Germ_Cell_Tumor	Extragonadal_Germ_Cell_Neoplasm	Stage II Extragonadal Primary Mixed Germ Cell Tumor|Stage II Extragonadal Primary Germ Cell Tumor Mixed
C8601	Retinal_Melanoma	Ocular_Melanoma	Retinal Melanoma|Malignant Melanoma of Retina|Malignant Melanoma of the Retina|Malignant Retinal Melanoma|Melanoma of Retina|Melanoma of the Retina	A melanoma affecting the retinal portion of the eye. --2003
C8602	Pleomorphic_Adenoma	Adenoma|Mixed_Neoplasm	Pleomorphic Adenoma
C8603	Renal_Pelvis_Papillary_Neoplasm	Papillary_Urothelial_Neoplasm|Renal_Pelvis_Neoplasm	Renal Pelvis Papillary Urothelial Neoplasm|Papillary Neoplasm of Renal Pelvis|Papillary Neoplasm of the Renal Pelvis|Papillary Tumor of Renal Pelvis|Papillary Tumor of the Renal Pelvis|Renal Pelvis Papillary Tumor	A papillary tumor originating in the renal pelvis.
C8604	Recurrent_Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia	Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia|Recurrent_B-Cell_Non-Hodgkin_s_Lymphoma	Recurrent Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia|Recurrent Lymphoplasmacytoid Lymphoma/Immunocytoma|Recurrent Waldenstrom's Macroglobulinemia|Relapsed Lymphoplasmacytoid Lymphoma/Immunocytoma|Relapsed Waldenstrom's Macroglobulinemia|Waldenstrom's Macroglobulinemia Recurrent	The reemergence of Waldenstrom's macroglobulinaemia after a period of remission.
C8605	Anaplastic_Malignant_Intraspinal_Meningioma	Anaplastic_Malignant_Meningioma|Intraspinal_Meningioma	Anaplastic (Malignant) Intraspinal Meningioma|Anaplastic Intraspinal Meningioma|Malignant Intraspinal Meningioma|Malignant Meningioma of Spinal Canal and Spinal Cord|Malignant Meningioma of the Spinal Canal and Spinal Cord|Malignant Spinal Canal and Spinal Cord Meningioma	Abnormal malignant growth of the tissues that comprise the spinal meninges: pia, arachnoid, dura.
C8606	Stage_II_Testicular_Choriocarcinoma	Stage_II_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Testicular_Choriocarcinoma	Stage II Testicular Choriocarcinoma|Testicular Choriocarcinoma Stage II
C8607	Recurrent_Inflammatory_Breast_Carcinoma	Inflammatory_Breast_Carcinoma	Recurrent Inflammatory Breast Carcinoma|Recurrent Inflammatory Carcinoma of Breast|Recurrent Inflammatory Carcinoma of the Breast	The reemergence of inflammatory carcinoma of the breast after a period of remission
C8608	Congenital_Epilepsy	Epilepsy	Congenital Epilepsy
C8609	Malignant_Hepato-Biliary_Neoplasm	Hepato-Biliary_Neoplasm	Malignant Hepato-Biliary Neoplasm
C8610	Metastatic_Neoplasm_to_the_Adrenal_Gland	Malignant_Adrenal_Gland_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Adrenal Gland|Metastases to Adrenals|Metastasis to Adrenals|Metastatic Neoplasm to the Adrenal Gland|Metastatic Neoplasm to the Adrenals|Metastatic Tumor to the Adrenal Gland|Metastatic Tumor to the Adrenals	A malignant tumor that has spread to the adrenal gland from an adjacent or distant anatomic site.  The majority of cases are metastatic carcinomas, and less frequently lymphomas.  (NCI05)
C8612	Benign_Peritoneal_Neoplasm	Peritoneal_Neoplasm	Benign Peritoneal Neoplasm
C8613	Myeloid_Sarcoma_in_Remission	Acute_Myeloid_Leukemia_in_Remission	Myeloid Sarcoma in Remission|Chloroma (in Remission)|Chloroma in Remission	A myeloid sarcoma that is responding to therapy, i.e. is not progressing and possibly regressing.  --2003
C8614	Hepato-Biliary_Neoplasm	Gastrointestinal_Neoplasm|Liver_and_Biliary_Tract_Disorder	Hepato-Biliary Neoplasm|Hepatic and Biliary Neoplasms|Hepatic and Biliary Tumors|Hepatic, Biliary, and Gallbladder Neoplasms|Hepato-Biliary Tract Neoplasm|Hepato-Biliary Tract Tumor|Hepato-Biliary Tumor|Hepatobiliary Neoplasm|Hepatobiliary Tumor|Hepatobiliary Tumors|Neoplasm of Hepato-Biliary Tract|Neoplasm of the Hepato-Biliary Tract|Tumor of Hepato-Biliary Tract|Tumor of the Hepato-Biliary Tract
C8615	Metastatic_Neoplasm_to_the_Abdominal_Cavity	Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Abdominal Cavity|Metastases to the Abdominal Cavity|Metastasis to the Abdominal Cavity|Metastatic Neoplasm to the Abdominal Cavity|Metastatic Tumor to the Abdominal Cavity	The spread of cancer from a primary site to an unspecified organ in the abdominal cavity.
C8616	Chronic_Myelomonocytic_Leukemia_in_Remission	Chronic_Leukemia_in_Remission|Myeloid_Leukemia_in_Remission	Chronic Myelomonocytic Leukemia in Remission|CMML in Remission|Chronic Myelomonocytic Leukaemia (in Remission)	Chronic myelomonocytic leukemia not growing; responding to treatment
C8617	Pure_Erythroid_Leukemia_in_Remission	Acute_Erythroid_Leukemia_in_Remission	Pure Erythroid Leukemia in Remission	Pure erythroid leukemia that is responding to therapy, i.e. It is not progressing and possibly regressing
C8619	Intracranial_Tumor_Hemorrhage	Hemorrhage	Intracranial Tumor Hemorrhage
C8625	Recurrent_Colorectal_Cancer	Colorectal_Carcinoma|Recurrent_Gastrointestinal_System_Cancer	Recurrent Colorectal Cancer|Colorectal Cancer, Recurrent|Colorectal Carcinoma Recurrent|Recurrent Colorectal Carcinoma	The reemergence of colorectal cancer after a period of remission
C8626	Stage_IV_Gastric_Cancer_with_Metastasis	Stage_IV_Gastric_Cancer	Stage IV Gastric Cancer with Metastasis|Stage IV Gastric Carcinoma with Metastasis	T4,N2,MO (from PDQ)
C8627	Recurrent_Esophageal_Adenocarcinoma	Esophageal_Adenocarcinoma|Recurrent_Esophageal_Cancer	Recurrent Esophageal Adenocarcinoma|Esophageal Adenocarcinoma, Recurrent|Oesophageal Adenocarcinoma Recurrent|Recurrent Adenocarcinoma of Esophagus|Recurrent Adenocarcinoma of the Esophagus|Recurrent Esophagus Adenocarcinoma|Relapsed Adenocarcinoma of Esophagus|Relapsed Adenocarcinoma of the Esophagus|Relapsed Esophageal Adenocarcinoma|Relapsed Esophagus Adenocarcinoma	Esophageal adenocarcinoma that reappears after treatment.
C8628	Stage_II_Esophageal_Adenocarcinoma	Esophageal_Adenocarcinoma|Stage_II_Esophageal_Cancer	Stage II Esophageal Adenocarcinoma|Esophageal Adenocarcinoma, Stage II|Oesophageal Adenocarcinoma Stage II|Stage II Adenocarcinoma of Esophagus|Stage II Adenocarcinoma of the Esophagus|Stage II Esophagus Adenocarcinoma	Stage 2 includes T2 or T3, N0, M0 and T1 or T2, N1, M0.  T2: Tumor invades muscularis propria.  T3: Tumor invades adventitia.  N0: No regional lymph node metastasis; N1: Regional lymph node metastasis; M0 No distant metastasis.(AJCC 6th Ed.) - 2003
C8629	Stage_0_Esophageal_Adenocarcinoma	Adenocarcinoma_in_situ|Esophageal_Adenocarcinoma|Esophageal_High-Grade_Glandular_Intraepithelial_Neoplasia|Grade_III_Glandular_Intraepithelial_Neoplasia|Stage_0_Esophageal_Cancer	Stage 0 Esophageal Adenocarcinoma|Adenocarcinoma in situ of Esophagus|Adenocarcinoma in situ of the Esophagus|Esophageal Adenocarcinoma in situ|Esophageal Adenocarcinoma, Stage 0|Esophagus Adenocarcinoma in situ|Oesophageal Adenocarcinoma Stage 0|Stage 0 Adenocarcinoma of Esophagus|Stage 0 Adenocarcinoma of the Esophagus|Stage 0 Esophagus Adenocarcinoma	Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.)-2003
C8630	Stage_I_Esophageal_Adenocarcinoma	Esophageal_Adenocarcinoma|Stage_I_Esophageal_Cancer	Stage I Esophageal Adenocarcinoma|Esophageal Adenocarcinoma, Stage I|Oesophageal Adenocarcinoma Stage I|Stage I Adenocarcinoma of Esophagus|Stage I Adenocarcinoma of the Esophagus|Stage I Esophagus Adenocarcinoma	Stage 1 includes T1, N0, M0.  T1: Tumor invades lamina propria or submucosa; N0: No regional lymph node metastasis; M0: No distance metastasis. (AJCC 6th Edition)-2003
C8631	Stage_III_Esophageal_Adenocarcinoma	Esophageal_Adenocarcinoma|Stage_III_Esophageal_Cancer	Stage III Esophageal Adenocarcinoma|Esophageal Adenocarcinoma, Stage III|Oesophageal Adenocarcinoma Stage III|Stage III Adenocarcinoma of Esophagus|Stage III Adenocarcinoma of the Esophagus|Stage III Esophagus Adenocarcinoma	Stage 3 includes T3,N1,M0/T4,anyN,M0. T4: Tumor invades adjacent structures (from PDQ).
C8632	Stage_IV_Esophageal_Adenocarcinoma	Esophageal_Adenocarcinoma|Stage_IV_Esophageal_Cancer	Stage IV Esophageal Adenocarcinoma|Esophageal Adenocarcinoma, Stage IV|Metastatic Adenocarcinoma of Esophagus|Metastatic Adenocarcinoma of the Esophagus|Metastatic Esophageal Adenocarcinoma|Metastatic Esophagus Adenocarcinoma|Oesophageal Adenocarcinoma Stage IV|Stage IV Adenocarcinoma of Esophagus|Stage IV Adenocarcinoma of the Esophagus|Stage IV Esophagus Adenocarcinoma	Stage 4 includes anyT, anyN, M1or M1a or M1b.  M1: Distant metastasis. Tumors of the lower thoracic esophagus.  M1a: Metastasis in celiac lymph nodes. M1b: Other distant metastasis. Tumors of the mid-thoracic esophagus.  M1a :Not applicable.  M1b: Nonregional lymph nodes and/or other distant metastasis.  Tumors of the upper thoracic esophagus.  M1a: Metastasis in cervical nodes.  M1b: Other distant metastasis (from PDQ)
C8633	Recurrent_Esophageal_Squamous_Cell_Carcinoma	Esophageal_Squamous_Cell_Carcinoma|Recurrent_Esophageal_Cancer	Recurrent Esophageal Squamous Cell Carcinoma|Recurrent Squamous Cell Carcinoma of Esophagus|Recurrent Squamous Cell Carcinoma of the Esophagus	An esophageal squamous cell carcinoma which has reappeared after a period of remission or after presumed treatment.
C8634	Recurrent_Rectosigmoid_Carcinoma	Rectosigmoid_Carcinoma|Recurrent_Colorectal_Cancer	Recurrent Rectosigmoid Cancer|Rectosigmoid Cancer, Recurrent|Recurrent Rectosigmoid Carcinoma|Relapsed Rectosigmoid Cancer	The reemergence of rectosigmoid cancer after a period of remission.
C8635	Stage_III_Rectosigmoid_Cancer	Rectosigmoid_Carcinoma|Stage_III_Colorectal_Cancer	Stage III Rectosigmoid Cancer|Stage III Rectosigmoid Carcinoma	Stage 3 includes anyT,N1,N2,M0, N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes (PDQ).
C8636	Stage_IV_Rectosigmoid_Cancer	Rectosigmoid_Carcinoma|Stage_IV_Colorectal_Cancer	Stage IV Rectosigmoid Cancer|Stage IV Rectosigmoid Carcinoma	Stage 4 includes anyT, anyN, M1.  M1:Distant metastasis
C8637	Metastatic_Small_Intestinal_Carcinoma	Small_Intestinal_Carcinoma	Metastatic Small Intestinal Carcinoma|Metastatic Carcinoma from the Small Bowel|Metastatic Carcinoma from the Small Intestine|Metastatic Small Bowel Carcinoma|Metastatic Small Intestine Cancer	Carcinoma capable of spreading which has originated in the small intestine.
C8638	Unresectable_Small_Intestinal_Cancer	Small_Intestinal_Carcinoma	Unresectable Small Intestinal Cancer|Non-Resectable Carcinoma of Small Bowel|Non-Resectable Carcinoma of Small Intestine|Non-Resectable Carcinoma of the Small Bowel|Non-Resectable Carcinoma of the Small Intestine|Non-Resectable Small Bowel Carcinoma|Non-Resectable Small Intestine Carcinoma|Small Intestine Carcinoma, Non-Resectable|Unresectable Small Intestine Carcinoma	Carcinoma of the small intestine not amendable to resection.
C8639	Resectable_Small_Intestinal_Cancer	Small_Intestinal_Carcinoma	Resectable Small Intestinal Cancer|Resectable Carcinoma of Small Bowel|Resectable Carcinoma of Small Intestine|Resectable Carcinoma of the Small Bowel|Resectable Carcinoma of the Small Intestine|Resectable Small Bowel Carcinoma|Resectable Small Intestine Carcinoma|Small Intestine Carcinoma, Resectable	Carcinoma of the small intestine amendable to resection.
C8640	Resectable_Extrahepatic_Bile_Duct_Carcinoma	Extrahepatic_Bile_Duct_Carcinoma	Resectable Extrahepatic Bile Duct Carcinoma|Bile Duct Cancer, Resectable|Resectable Bile Duct Cancer|Resectable Cancer of Bile Duct|Resectable Cancer of the Bile Duct	Bile duct cancer amenable to surgical removal.
C8641	Unresectable_Hepatoblastoma	Hepatoblastoma	Unresectable Hepatoblastoma|Hepatoblastoma, Nonresectable|Non-Resectable Hepatoblastoma	Hepatoblastoma not amenable to surgical removal.
C8642	Resectable_Hepatoblastoma	Hepatoblastoma	Resectable Hepatoblastoma|Hepatoblastoma, Resectable	Hepatoblastoma amenable to surgical removal.
C8643	Recurrent_Hepatoblastoma	Hepatoblastoma|Recurrent_Childhood_Liver_Cancer	Recurrent Hepatoblastoma|Hepatoblastoma, Recurrent|Relapsed Hepatoblastoma	The reemergence of hepatoblastoma after a period of remission.
C8644	Precursor_B_Lymphoblastic_Leukemia	Acute_Lymphoblastic_Leukemia|Common_Hematopoietic_Neoplasm|Precursor_B_Lymphoblastic_Leukemia_Lymphoma	Precursor B-Lymphoblastic Leukemia|Acute B Cell Lymphocytic Leukemia|Acute B-Cell Lymphocytic Leukemia|B Cell Acute Lymphocytic Leukemia|B Cell Precursor Type Acute Leukemia|B-Cell Acute Lymphoblastic Leukemia|B-Cell Acute Lymphocytic Leukemia|B-Cell Lymphoblastic Leukemia|B-Cell Precursor Type Acute Leukemia|B-Cell Type Acute Leukemia	The most frequent type of acute lymphoblastic leukemia.  Approximately 75% of cases occur in children under six years of age.  This is a good prognosis leukemia.  In the pediatric age group the complete remission rate is approximately 95% and the disease free survival rate is 70%.  Approximately 80% of children appear to be cured.  In the adult age group the complete remission rate is 60-85%.  (WHO, 2001) -- 2003
C8645	Recurrent_Chronic_Lymphocytic_Leukemia	Chronic_Lymphocytic_Leukemia|Relapsed_Hematologic_Malignancy	Recurrent Chronic Lymphocytic Leukemia|Chronic Lymphocytic Leukemia Recurrent|Recurrent Chronic Lymphogenous Leukemia|Recurrent Chronic Lymphoid Leukemia|Relapsed Chronic Lymphocytic Leukemia|Relapsed Chronic Lymphogenous Leukemia|Relapsed Chronic Lymphoid Leukemia	The reemergence of chronic lymphocytic leukemia after a period of remission.
C8646	Stage_IV_Chronic_Lymphocytic_Leukemia	Chronic_Lymphocytic_Leukemia	Stage IV Chronic Lymphocytic Leukemia|CLL Stage IV|Chronic Lymphocytic Leukemia Stage IV|Metastatic CLL|Metastatic Chronic Lymphocytic Leukemia|Stage IV CLL|stage IV chronic lymphocytic leukemia	Stage IV chronic lymphocytic leukemia: absolute lymphocytosis and thrombocytopenia (<100,000 per cubic millimeter) with or without lymphadenopathy, hepatomegaly, splenomegaly, or anemia.
C8647	Aggressive_NK-Cell_Leukemia	Chronic_Leukemia|Lymphoid_Leukemia|Mature_T-Cell_and_NK-Cell_Neoplasm	Aggressive NK-Cell Leukemia|Large Granular Lymphocyte Leukemia, NK-Cell Type|NK Cell Leukemia|NK-Cell Leukemia|Natural Killer Cell Leukemia	A rare, highly aggressive, Epstein-Barr virus-associated leukemia/lymphoma, also known as aggressive NK-cell leukemia/lymphoma, it may represent the leukemic counterpart of nasal type extranodal NK/T-cell lymphomas.  It affects primarily teenagers and young adults.  It is characterized by the systemic proliferation of NK cells in the peripheral blood, bone marrow, liver, and spleen.--2004
C8648	Myelodysplastic_Syndrome_Unclassifiable	Myelodysplastic_Syndrome	Myelodysplastic Syndrome, Unclassifiable|MDS, U|MDS-U|Unclassifiable MDS|Unclassifiable Myelodysplastic Syndrome	A myelodysplastic syndrome characterized by neutropenia or thrombocytopenia and dysplasia restricted to neutrophil or megakaryocytic cell lines.  The blasts in the bone marrow and blood are not increased.  (WHO, 2001) -- 2003
C8649	Recurrent_Lymphocyte_Depleted_Hodgkin_s_Lymphoma	Lymphocyte_Depleted_Hodgkin_s_Lymphoma|Recurrent_Hodgkin_s_Lymphoma	Recurrent Lymphocyte Depleted Hodgkin's Lymphoma|Recurrent Hodgkin's Disease Lymphocyte Depletion Type|Recurrent Hodgkin's Lymphoma Lymphocyte Depleted|Recurrent Hodgkin's Lymphoma Lymphocyte Depletion Type|Relapsed Hodgkin's Disease Lymphocyte Depletion Type|Relapsed Hodgkin's Lymphoma Lymphocyte Depletion Type
C8650	Refractory_Lymphocyte_Depleted_Hodgkin_s_Lymphoma	Lymphocyte_Depleted_Hodgkin_s_Lymphoma|Refractory_Hodgkin_s_Lymphoma	Refractory Lymphocyte Depleted Hodgkin's Lymphoma|Refractory Hodgkin's Disease Lymphocyte Depleted|Refractory Hodgkin's Lymphoma Lymphocyte Depleted|Refractory Hodgkin's Lymphoma Lymphocyte Depletion Type|Refractory Lymphocyte Depleted Hodgkin's Disease	Hodgkin's disease lymphocyte depletion resistant to treatment.
C8651	Stage_IV_Lymphocyte_Depleted_Hodgkin_s_Lymphoma	Lymphocyte_Depleted_Hodgkin_s_Lymphoma|Stage_IV_Hodgkin_s_Lymphoma	Stage IV Lymphocyte Depleted Hodgkin's Lymphoma|Stage IV Hodgkin's Disease Lymphocyte Depleted|Stage IV Hodgkin's Disease Lymphocyte Depletion Type|Stage IV Hodgkin's Lymphoma Lymphocyte Depletion Type	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8652	Refractory_Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia	Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia|Refractory_Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Refractory Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia|Refractory Lymphoplasmacytoid Lymphoma/Immunocytoma|Refractory Waldenstrom's Macroglobulinemia|Waldenstrom's Macroglobulinemia Refractory	Waldenstrom's macroglobulinaemia resistant to treatment.
C8653	Stage_I_Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia	Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia|Stage_I_B-Cell_Non-Hodgkin_s_Lymphoma	Stage I Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia|Lymphoplasmacytoid Lymphoma/Immunocytoma Stage I|Stage I Lymphoplasmacytoid Lymphoma/Immunocytoma|Stage I Waldenstrom's Macroglobulinemia|Waldenstrom's Macroglobulinemia Stage I	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C8654	Stage_II_Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia	Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia|Stage_II_B-Cell_Non-Hodgkin_s_Lymphoma	Stage II Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia|Lymphoplasmacytoid Lymphoma/Immunocytoma Stage II|Stage II Lymphoplasmacytoid Lymphoma/Immunocytoma|Stage II Waldenstrom's Macroglobulinemia|Waldenstrom's Macroglobulinemia Stage II	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C8655	Stage_III_Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia	Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia|Stage_III_B-Cell_Non-Hodgkin_s_Lymphoma	Stage III Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia|Lymphoplasmacytoid Lymphoma/Immunocytoma Stage III|Stage III Lymphoplasmacytoid Lymphoma/Immunocytoma|Stage III Waldenstrom's Macroglobulinemia|Waldenstrom's Macroglobulinemia Stage III	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C8656	Stage_IV_Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia	Lymphoplasmacytic_Lymphoma_Waldenstrom_s_Macroglobulinemia|Stage_IV_B-Cell_Non-Hodgkin_s_Lymphoma	Stage IV Lymphoplasmacytic Lymphoma/Waldenstrom's Macroglobulinemia|Lymphoplasmacytoid Lymphoma/Immunocytoma Stage IV|Stage IV Lymphoplasmacytoid Lymphoma/Immunocytoma|Stage IV Waldenstrom's Macroglobulinemia|Waldenstrom's Macroglobulinemia Stage IV	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8657	Refractory_Adult_T-Cell_Lymphoma_Leukemia	Adult_T-Cell_Lymphoma_Leukemia|Refractory_Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Refractory Adult T-Cell Lymphoma/Leukemia|Adult T-Cell Lymphoma/Leukemia Refractory	Adult T-cell lymphoma/leukemia that is resistant to treatment
C8658	Refractory_Anaplastic_Large_Cell_Lymphoma	Anaplastic_Large_Cell_Lymphoma|Refractory_Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Refractory Anaplastic Large Cell Lymphoma|Anaplastic Large Cell Lymphoma T- and Null-cell Types Refractory	Anaplastic large cell lymphoma t-and null cell types resistant to treatment
C8659	Stage_I_Anaplastic_Large_Cell_Lymphoma	Anaplastic_Large_Cell_Lymphoma|Stage_I_Mature_T-and_NK-Cell_Lymphoma	Stage I Anaplastic Large Cell Lymphoma|Anaplastic Large Cell Lymphoma Stage I|Anaplastic Large Cell Lymphoma T- and Null-Cell Types Stage I	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C8660	Stage_II_Anaplastic_Large_Cell_Lymphoma	Anaplastic_Large_Cell_Lymphoma|Stage_II_Mature_T-and_NK-Cell_Lymphoma	Stage II Anaplastic Large Cell Lymphoma|Anaplastic Large Cell Lymphoma Stage II|Anaplastic Large Cell Lymphoma T- and Null-Cell Types Stage II	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C8661	Stage_III_Anaplastic_Large_Cell_Lymphoma	Anaplastic_Large_Cell_Lymphoma|Stage_III_Mature_T-and_NK-Cell_Lymphoma	Stage III Anaplastic Large Cell Lymphoma|Anaplastic Large Cell Lymphoma Stage III|Anaplastic Large Cell Lymphoma T- and Null-Cell Types Stage III	Ann Arbor Classification. Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C8662	Stage_IV_Anaplastic_Large_Cell_Lymphoma	Anaplastic_Large_Cell_Lymphoma|Stage_IV_Mature_T-and_NK-Cell_Lymphoma	Stage IV Anaplastic Large Cell Lymphoma|Anaplastic Large Cell Lymphoma Stage IV|Anaplastic Large Cell Lymphoma T- and Null-Cell Types Stage IV	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8663	Recurrent_T-Cell_Non-Hodgkin_s_Lymphoma	Recurrent_Non-Hodgkin_s_Lymphoma|T-Cell_Non-Hodgkin_s_Lymphoma	Recurrent T-Cell Non-Hodgkin's Lymphoma|Recurrent T-Cell Lymphoma|Recurrent T-Cell and NK-Cell Non-Hodgkin's Lymphoma|Relapsed T-Cell Lymphoma|T-Cell Lymphoma Recurrent|T-Cell Lymphoma Relapsed	The reemergence of T-cell lymphoma after a period of remission.
C8664	Refractory_T-Cell_Non-Hodgkin_s_Lymphoma	Refractory_Non-Hodgkin_s_Lymphoma|T-Cell_Non-Hodgkin_s_Lymphoma	Refractory T-Cell Non-Hodgkin's Lymphoma|Refractory T-Cell Lymphoma|Refractory T-Cell and NK-Cell Non-Hodgkin's Lymphoma|T-Cell Lymphoma Refractory	T-cell non-Hodgkin's lymphoma resistant to treatment.
C8665	Stage_I_T-Cell_Non-Hodgkin_s_Lymphoma	Stage_I_Non-Hodgkin_s_Lymphoma|T-Cell_Non-Hodgkin_s_Lymphoma	Stage I T-Cell Non-Hodgkin's Lymphoma|Stage I T Cell Lymphoma|Stage I T-Cell Lymphoma|T Cell Lymphoma Stage I|T-Cell Lymphoma Stage I	Stage I NHL means involvement of a single lymph node region (I) or localized involvement of a single extralymphatic organ or site (IE). (PDQ)
C8666	Stage_II_T-Cell_Non-Hodgkin_s_Lymphoma	Stage_II_Non-Hodgkin_s_Lymphoma|T-Cell_Non-Hodgkin_s_Lymphoma	Stage II T-Cell Non-Hodgkin's Lymphoma|Stage II T Cell Lymphoma|Stage II T-Cell Lymphoma|T Cell Lymphoma Stage II|T-Cell Lymphoma Stage II	Stage II NHL means involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (PDQ)
C8667	Stage_III_T-Cell_Non-Hodgkin_s_Lymphoma	Stage_III_Non-Hodgkin_s_Lymphoma|T-Cell_Non-Hodgkin_s_Lymphoma	Stage III T-Cell Non-Hodgkin's Lymphoma|Stage III T Cell Lymphoma|Stage III T-Cell Lymphoma|T Cell Lymphoma Stage III|T-Cell Lymphoma Stage III	Stage III NHL means involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (PDQ)
C8668	Stage_IV_T-Cell_Non-Hodgkin_s_Lymphoma	Stage_IV_Non-Hodgkin_s_Lymphoma|T-Cell_Non-Hodgkin_s_Lymphoma	Stage IV T-Cell Non-Hodgkin's Lymphoma|Metastatic T Cell Lymphoma|Metastatic T-Cell Lymphoma|Stage IV T Cell Lymphoma|Stage IV T-Cell Lymphoma|T Cell Lymphoma Stage IV|T-Cell Lymphoma Stage IV	Stage IV NHL means disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)
C8669	Refractory_Nasal_Type_Extranodal_NK_T-Cell_Lymphoma	Nasal_Type_Extranodal_NK_T-Cell_Lymphoma|Refractory_Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Refractory Nasal Type Extranodal NK/T-Cell Lymphoma|Angiocentric Lymphoma Refractory|Refractory Angiocentric Lymphoma|Refractory Nasal/Nasal Type T/NK-Cell Lymphoma
C8670	Stage_I_Nasal_Type_NK_T-Cell_Lymphoma	Nasal_Type_Extranodal_NK_T-Cell_Lymphoma|Stage_I_Mature_T-and_NK-Cell_Lymphoma	Stage I Nasal Type NK/T-Cell Lymphoma|Angiocentric Lymphoma Stage I|Stage I Angiocentric Lymphoma	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C8671	Refractory_Angioimmunoblastic_T-cell_Lymphoma	Angioimmunoblastic_T-Cell_Lymphoma|Refractory_Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Refractory Angioimmunoblastic T-cell Lymphoma|Angioimmunoblastic T-Cell Lymphoma Refractory	Angioimmunoblastic T-cell lymphoma resistant to treatment
C8672	Stage_I_Angioimmunoblastic_T-cell_Lymphoma	Angioimmunoblastic_T-Cell_Lymphoma|Stage_I_Mature_T-and_NK-Cell_Lymphoma	Stage I Angioimmunoblastic T-cell Lymphoma|Angioimmunoblastic T-Cell Lymphoma Stage I	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C8673	Stage_II_Nasal_Type_NK_T-Cell_Lymphoma	Nasal_Type_Extranodal_NK_T-Cell_Lymphoma|Stage_II_Mature_T-and_NK-Cell_Lymphoma	Stage II Nasal Type NK/T-Cell Lymphoma|Angiocentric Lymphoma Stage II|Stage II Angiocentric Lymphoma	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C8674	Stage_III_Nasal_Type_NK_T-Cell_Lymphoma	Nasal_Type_Extranodal_NK_T-Cell_Lymphoma|Stage_III_Mature_T-and_NK-Cell_Lymphoma	Stage III Nasal Type NK/T-Cell Lymphoma|Angiocentric Lymphoma Stage III|Stage III Angiocentric Lymphoma	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C8675	Stage_IV_Nasal_Type_NK_T-Cell_Lymphoma	Nasal_Type_Extranodal_NK_T-Cell_Lymphoma|Stage_IV_Mature_T-and_NK-Cell_Lymphoma	Stage IV Nasal Type NK/T-Cell Lymphoma|Angiocentric Lymphoma Stage IV|Stage IV Angiocentric Lymphoma	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s).  Any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8676	Recurrent_Angioimmunoblastic_T-cell_Lymphoma	Angioimmunoblastic_T-Cell_Lymphoma|Recurrent_Mature_T-and_NK-Cell_Non-Hodgkin_s_Lymphoma	Recurrent Angioimmunoblastic T-cell Lymphoma|Relapsed Angioimmunoblastic T-cell Lymphoma	The reemergence of angioimmunoblastic T-cell lymphoma after a period of remission
C8677	Stage_II_Angioimmunoblastic_T-cell_Lymphoma	Angioimmunoblastic_T-Cell_Lymphoma|Stage_II_Mature_T-and_NK-Cell_Lymphoma	Stage II Angioimmunoblastic T-cell Lymphoma|Angioimmunoblastic T-Cell Lymphoma Stage II	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C8678	Stage_III_Angioimmunoblastic_T-cell_Lymphoma	Angioimmunoblastic_T-Cell_Lymphoma|Stage_III_Mature_T-and_NK-Cell_Lymphoma	Stage III Angioimmunoblastic T-cell Lymphoma|Angioimmunoblastic T-Cell Lymphoma Stage III	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C8679	Stage_IV_Angioimmunoblastic_T-cell_Lymphoma	Angioimmunoblastic_T-Cell_Lymphoma|Stage_IV_Mature_T-and_NK-Cell_Lymphoma	Stage IV Angioimmunoblastic T-cell Lymphoma|Angioimmunoblastic T-Cell Lymphoma Stage IV	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8680	Recurrent_Enteropathy-type_T-Cell_Lymphoma	Enteropathy-Type_T-Cell_Lymphoma|Recurrent_Mature_T-and_NK-Cell_Non-Hodgkin_s_Lymphoma	Recurrent Enteropathy-type T-Cell Lymphoma|Recurrent Intestinal T-Cell Lymphoma|Relapsed Intestinal T-Cell Lymphoma
C8681	Refractory_Enteropathy-type_T-Cell_Lymphoma	Enteropathy-Type_T-Cell_Lymphoma|Refractory_Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Refractory Enteropathy-type T-Cell Lymphoma|Intestinal T-Cell Lymphoma Refractory|Refractory Intestinal T-Cell Lymphoma	Intestinal T-cell lymphoma that is resistant to treatment.
C8682	Stage_I_Enteropathy-type_T-Cell_Lymphoma	Enteropathy-Type_T-Cell_Lymphoma|Stage_I_Mature_T-and_NK-Cell_Lymphoma	Stage I Enteropathy-type T-Cell Lymphoma|Intestinal T-Cell Lymphoma Stage I|Stage I Intestinal T-Cell Lymphoma	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).-2003
C8683	Stage_II_Enteropathy-type_T-Cell_Lymphoma	Enteropathy-Type_T-Cell_Lymphoma|Stage_II_Mature_T-and_NK-Cell_Lymphoma	Stage II Enteropathy-type T-Cell Lymphoma|Intestinal T-Cell Lymphoma Stage II|Stage II Intestinal T-Cell Lymphoma	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C8684	Stage_III_Enteropathy-type_T-Cell_Lymphoma	Enteropathy-Type_T-Cell_Lymphoma|Stage_III_Mature_T-and_NK-Cell_Lymphoma	Stage III Enteropathy-type T-Cell Lymphoma|Intestinal T-Cell Lymphoma Stage III|Stage III Intestinal T-Cell Lymphoma	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C8685	Stage_IV_Enteropathy-type_T-Cell_Lymphoma	Enteropathy-Type_T-Cell_Lymphoma|Stage_IV_Mature_T-and_NK-Cell_Lymphoma	Stage IV Enteropathy-type T-Cell Lymphoma|Intestinal T-Cell Lymphoma Stage IV|Stage IV Intestinal T-Cell Lymphoma	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8686	Recurrent_Mycosis_Fungoides	Mycosis_Fungoides|Recurrent_Cutaneous_T-Cell_Lymphoma	Recurrent Mycosis Fungoides|Mycosis Fungoides Recurrent|Mycosis Fungoides Relapsed|Relapsed Mycosis Fungoides
C8687	Refractory_Mycosis_Fungoides	Mycosis_Fungoides|Refractory_Cutaneous_T-Cell_Lymphoma	Refractory Mycosis Fungoides|Mycosis Fungoides Refractory	Mycosis fungoides resistant to treatment
C8688	Recurrent_Mature_T-and_NK-Cell_Non-Hodgkin_s_Lymphoma	Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma|Recurrent_T-Cell_Non-Hodgkin_s_Lymphoma	Recurrent Mature T- and NK-Cell Non-Hodgkin's Lymphoma|Recurrent Mature T- and NK-Cell Lymphoma|Recurrent Peripheral T-cell Lymphoma|Relapsed Peripheral T-cell Lymphoma
C8689	Refractory_Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma|Refractory_T-Cell_Non-Hodgkin_s_Lymphoma	Refractory Mature T-Cell and NK-Cell Non-Hodgkin's Lymphoma|Peripheral T-Cell Lymphoma Refractory|Refractory Mature T- and NK-Cell Lymphoma|Refractory Peripheral T-cell Lymphoma	Peripheral T-cell lymphoma unspecified resistant to treatment
C8690	Stage_I_Mature_T-and_NK-Cell_Lymphoma	Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma|Stage_I_T-Cell_Non-Hodgkin_s_Lymphoma	Stage I Mature T- and NK-Cell Lymphoma|Peripheral T-cell Lymphoma Stage I|Stage I Peripheral T-cell Lymphoma
C8691	Stage_II_Mature_T-and_NK-Cell_Lymphoma	Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma|Stage_II_T-Cell_Non-Hodgkin_s_Lymphoma	Stage II Mature T- and NK-Cell Lymphoma|Peripheral T-Cell Lymphoma Stage II|Stage II Peripheral T-cell Lymphoma
C8692	Stage_III_Mature_T-and_NK-Cell_Lymphoma	Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma|Stage_III_T-Cell_Non-Hodgkin_s_Lymphoma	Stage III Mature T- and NK-Cell Lymphoma|Peripheral T-Cell Lymphoma Stage III|Stage III Peripheral T-cell Lymphoma
C8693	Stage_IV_Mature_T-and_NK-Cell_Lymphoma	Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma|Stage_IV_T-Cell_Non-Hodgkin_s_Lymphoma	Stage IV Mature T- and NK-Cell Lymphoma|Peripheral T-Cell Lymphoma Stage IV|Stage IV Peripheral T-cell Lymphoma
C8694	Precursor_T_Lymphoblastic_Leukemia_Lymphoma	Precursor_Lymphoblastic_Leukemia_Lymphoma|T-Cell_and_NK-Cell_Neoplasm	Precursor T-Lymphoblastic Lymphoma/Leukemia|Precursor T Lymphoblastic Leukemia/Lymphoma|Precursor T Lymphoblastic Lymphoma/Leukemia	A neoplasm of lymphoblasts committed to the T-cell lineage, typically composed of small to medium-sized blast cells.  When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is precursor T lymphoblastic leukemia (T-cell acute lymphoblastic leukemia).  When it involves nodal or extranodal sites it is T- lymphoblastic lymphoma. (WHO, 2001) -- 2003
C8695	Recurrent_Precursor_T_Lymphoblastic_Lymphoma_Leukemia	Precursor_T_Lymphoblastic_Leukemia_Lymphoma|Relapsed_Hematologic_Malignancy	Recurrent Precursor T-Lymphoblastic Lymphoma/Leukemia|Relapsed Precursor T Lymphoblastic Lymphoma/Leukemia
C8696	Refractory_Precursor_T_Lymphoblastic_Lymphoma_Leukemia	Precursor_T_Lymphoblastic_Leukemia_Lymphoma|Refractory_Hematologic_Malignancy	Refractory Precursor T-Lymphoblastic Lymphoma/Leukemia|Precursor T Lymphoblastic Lymphoma/Leukemia Refractory	Precursor T-lymphoblastic lymphoma/leukemia resistant to treatment
C8697	Stage_I_Precursor_T-Lymphoblastic_Lymphoma_Leukemia	Precursor_T_Lymphoblastic_Leukemia_Lymphoma	Stage I Precursor T-Lymphoblastic Lymphoma/Leukemia|Precursor T-Lymphoblastic Lymphoma/Leukemia Stage I	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (Rare in Hodgkin lymphoma). - 2003
C8698	Stage_II_Precursor_T-Lymphoblastic_Lymphoma_Leukemia	Precursor_T_Lymphoblastic_Leukemia_Lymphoma	Stage II Precursor T-Lymphoblastic Lymphoma/Leukemia|Precursor T-Lymphoblastic Lymphoma/Leukemia Stage II	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in a with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C8699	Stage_III_Precursor_T-Lymphoblastic_Lymphoma_Leukemia	Precursor_T_Lymphoblastic_Leukemia_Lymphoma	Stage III Precursor T-Lymphoblastic Lymphoma/Leukemia|Precursor T-Lymphoblastic Lymphoma/Leukemia Stage III	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C8700	Stage_IV_Precursor_T-Lymphoblastic_Lymphoma_Leukemia	Precursor_T_Lymphoblastic_Leukemia_Lymphoma	Stage IV Precursor T-Lymphoblastic Lymphoma/Leukemia|Precursor T-Lymphoblastic Lymphoma/Leukemia Stage IV	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow, or nodular involvement of the lungs(s). - 2003
C8701	Refractory_Non-Hodgkin_s_Lymphoma	Non-Hodgkin_s_Lymphoma|Refractory_Hematologic_Malignancy	Refractory Non-Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma Refractory|NonHodgkin's Lymphoma Refractory|Refractory Non-Hodgkin Lymphoma	A non-Hodgkin's lymphoma which does not respond to treatment
C8702	Transformed_Recurrent_Non-Hodgkin_s_Lymphoma	Recurrent_Non-Hodgkin_s_Lymphoma	Transformed Recurrent Non-Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma Transformed Recurrent|NonHodgkin's Lymphoma Transformed Recurrent	The reemergence of non-Hodgkin's lymphoma transformed after a period of remission
C8703	Advanced_Malignant_Pericardial_Mesothelioma	Advanced_Malignant_Mesothelioma|Malignant_Pericardial_Mesothelioma	Advanced Pericardial Malignant Mesothelioma|Pericardial Mesothelioma Malignant Advanced	A malignant mesothelioma extensively involving the pericardium. -- 2003
C8704	Advanced_Malignant_Peritoneal_Mesothelioma	Advanced_Malignant_Mesothelioma|Malignant_Peritoneal_Mesothelioma	Advanced Peritoneal Malignant Mesothelioma|Advanced Malignant Mesothelioma of Peritoneum|Advanced Malignant Mesothelioma of the Peritoneum|Malignant Peritoneal Mesothelioma, Advanced
C8705	Recurrent_Malignant_Peritoneal_Mesothelioma	Malignant_Peritoneal_Mesothelioma|Recurrent_Malignant_Mesothelioma	Recurrent Peritoneal Malignant Mesothelioma|Malignant Peritoneal Mesothelioma Recurrent|Recurrent Malignant Mesothelioma of Peritoneum|Recurrent Malignant Mesothelioma of the Peritoneum|Relapsed Malignant Mesothelioma of Peritoneum|Relapsed Malignant Mesothelioma of the Peritoneum|Relapsed Malignant Peritoneal Mesothelioma	The reemergence of malignant peritoneal mesothelioma after a period of remission
C8706	Advanced_Malignant_Pleural_Mesothelioma	Advanced_Malignant_Mesothelioma|Malignant_Pleural_Mesothelioma	Advanced Pleural Malignant Mesothelioma|Advanced Malignant Mesothelioma of Pleura|Advanced Malignant Mesothelioma of the Pleura|Malignant Pleural Mesothelioma, Advanced
C8707	Recurrent_Malignant_Pleural_Mesothelioma	Malignant_Pleural_Mesothelioma|Recurrent_Malignant_Mesothelioma	Recurrent Pleural Malignant Mesothelioma|Malignant Pleural Mesothelioma Recurrent|Relapsed Malignant Mesothelioma of Pleura|Relapsed Malignant Mesothelioma of the Pleura|Relapsed Malignant Pleural Mesothelioma	The reemergence of pleural malignant mesothelioma after a period of remission.
C8708	Metastatic_Angiosarcoma	Angiosarcoma	Metastatic Angiosarcoma|Metastatic Hemangiosarcoma
C8709	Metastatic_Malignant_Hemangiopericytoma	Malignant_Hemangiopericytoma	Metastatic Malignant Hemangiopericytoma
C8710	Primary_Malignant_Hemangiopericytoma	Malignant_Hemangiopericytoma	Primary Malignant Hemangiopericytoma|Malignant Hemangiopericytoma Nonmetastatic|Non-Metastatic Malignant Hemangiopericytoma	A rare malignant sarcoma that is believed to have its origin in smooth muscle derived pericytes without evidence of metastases
C8711	Non-Cutaneous_Melanoma	Melanoma	Non-Cutaneous Melanoma|Extracutaneous Melanoma	Melanoma is a malignant tumor of melanocytes, cells that are derived from the neural crest. Although most melanomas arise in the skin, they also may arise from mucosal surfaces or at other sites to which neural crest cells migrate. (PDQ)
C8712	Pineal_Germinoma	Brain_Germinoma|Germinoma_of_the_Central_Nervous_System|Pineal_Region_Germ_Cell_Tumor	Pineal Germinoma|Pineal Region Germinoma
C8713	Bilateral_Retinoblastoma	Retinoblastoma	Bilateral Retinoblastoma	Retinoblastoma involving both eyes. This occurs in the majority of patients with the inherited variant. A minority of patient with bilateral retinoblastoma were found to have involvement of the pineal gland as well.
C8714	Unilateral_Retinoblastoma	Retinoblastoma	Unilateral Retinoblastoma	A retinoblastoma that only involves a single eye.
C8715	Rhabdoid_Tumour_of_the_Kidney	Childhood_Renal_Neoplasm|Malignant_Renal_Neoplasm|Rhabdoid_Tumor	Rhabdoid Tumour of the Kidney|Kidney Rhabdoid Tumor|MRTK|Malignant Rhabdoid Tumor of Kidney|Malignant Rhabdoid Tumor of the Kidney|Renal Rhabdoid Neoplasm|Renal Rhabdoid Tumor|Rhabdoid Neoplasm of Kidney|Rhabdoid Neoplasm of the Kidney|Rhabdoid Tumour of Kidney	A primary renal tumor notable for clusters of acidophilic tumor cells separated by vascular septa. It can be seen concurrent with traditional Wilms tumor.  This tumor is known to metastasize to lung and brain. It is associated, in the literature, with a slight male predominance. (Pizzo and Poplack, Principles and practice of pediatric oncology, 3rd edition.)
C8716	Regional_Malignant_Ureter_Neoplasm	Malignant_Ureter_Neoplasm	Regional Malignant Ureter Neoplasm|Local Malignant Ureter Neoplasm|Local Malignant Ureter Tumor|Local Malignant Ureteral Neoplasm|Local Malignant Ureteral Tumor|Regional Malignant Ureter Tumor|Regional Malignant Ureteral Neoplasm|Regional Malignant Ureteral Tumor	Abnormal malignant growth of cells in the ureter without spread to any other region.
C8717	Mucin-Rich_Uterine_Corpus_Endometrioid_Adenocarcinoma	Uterine_Corpus_Endometrioid_Adenocarcinoma	Mucin-Rich Endometrial Endometrioid Adenocarcinoma
C8719	Endometrial_Squamous_Cell_Carcinoma	Endometrial_Carcinoma|Squamous_Cell_Carcinoma	Endometrial Squamous Cell Carcinoma|Squamous Cell Carcinoma of Endometrium|Squamous Cell Carcinoma of the Endometrium	Malignant neoplasms made of of squamous epithelial cells in the endometrium.
C8720	Stage_I_Fallopian_Tube_Cancer	Fallopian_Tube_Carcinoma	Stage I Fallopian Tube Cancer|AJCC Stage I Fallopian Tube Cancer|FIGO Stage I Carcinoma of Fallopian Tube|FIGO Stage I Carcinoma of the Fallopian Tube|FIGO Stage I Fallopian Tube Carcinoma|Fallopian Tube Cancer Stage I	Stage I includes: (T1, N0, M0); IA (T1a, N0, M0); IB (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor limited to the fallopian tube(s).  T1a: Tumor limited to one tube, without penetrating the serosal surface; no ascites.  T1b: Tumor limited to both tubes, without penetrating the serosal surface; no ascites.  T1c: Tumor limited to one or both tubes with extension onto or through the tubal serosa, or with malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C8721	Stage_II_Fallopian_Tube_Cancer	Fallopian_Tube_Carcinoma	Stage II Fallopian Tube Cancer|AJCC Stage II Fallopian Tube Cancer|FIGO Stage II Carcinoma of Fallopian Tube|FIGO Stage II Carcinoma of the Fallopian Tube|FIGO Stage II Fallopian Tube Carcinoma|Fallopian Tube Cancer Stage II	Stage II includes: (T2, N0, M0); IIA: (T2a, N0, M0); IIB (T2b, N0, M0); IIC (T2c, N0, M0).  T2: Tumor involves one or both fallopian tubes with pelvic extension.  T2a: Extension and/or metastasis to the uterus and/or ovaries.  T2b: Extension to other pelvic structures.  T2c: Pelvic extension with malignant cells or ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C8722	Stage_III_Fallopian_Tube_Cancer	Fallopian_Tube_Carcinoma	Stage III Fallopian Tube Cancer|AJCC Stage III Fallopian Tube Cancer|FIGO Stage III Carcinoma of Fallopian Tube|FIGO Stage III Carcinoma of the Fallopian Tube|FIGO Stage III Fallopian Tube Carcinoma|Fallopian Tube Cancer Stage III	Stage III includes: (T3, N0, M0); IIIA (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c, N0, M0).  T3: Tumor involves one or both fallopian tubes, with peritoneal implants outside the pelvis.  T3a: Microscopic peritoneal metastasis outside the pelvis.  T3b: Macroscopic peritoneal metastasis outside the pelvis 2cm or less in greatest dimension.  T3c: Peritoneal metastasis more than 2cm in diameter. (AJCC 6th ed.) - 2003
C8723	Stage_I_Ovarian_Dysgerminoma	Ovarian_Dysgerminoma|Stage_I_Ovarian_Germ_Cell_Tumor	Stage I Ovarian Dysgerminoma	Stage I includes: (T1, N0, M0). Also, IA: (T1a, N0, M0); IB: (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor limited to ovaries (one or both).  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1b: Tumor limited to one or both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.)-2003
C8724	Stage_II_Ovarian_Dysgerminoma	Ovarian_Dysgerminoma|Stage_II_Ovarian_Germ_Cell_Tumor	Stage II Ovarian Dysgerminoma	Stage II includes: (T2, N0, M0).  Also, IIA: (T2a, N0, M0); IIB: (T2b, N0, M0); IIC: (T2c, N0, M0). T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  T2a: Extension and/or implants on uterus and/or tube(s).  No malignant cells in ascites or peritoneal washings.  T2b: Extension to and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  T2c: Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washings.  N0: No regional metastasis.  (AJCC 6th Ed.) - 2003
C8725	Stage_II_Ovarian_Embryonal_Carcinoma	Ovarian_Embryonal_Carcinoma	Stage II Ovarian Embryonal Carcinoma|Ovarian Embryonal Carcinoma, Stage II	Stage II includes: (T2, N0, M0).  Also, IIA: (T2a, N0, M0); IIB: (T2b, N0, M0); IIC: (T2c, N0, M0).  T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  T2a: Extension and/or implants on uterus and/or tube(s).  No malignant cells in ascites or peritoneal washings.  T2b: Extension to and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  T2c: Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washings.  N0: No regional metastasis. (AJCC 6th Ed.) - 2003
C8726	Stage_III_Ovarian_Dysgerminoma	Ovarian_Dysgerminoma|Stage_III_Ovarian_Germ_Cell_Tumor	Stage III Ovarian Dysgerminoma	Stage III includes: (T3, N0, M0).  Also, IIIA: (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c N0, M0) and (Any T, N1, M0).  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor).  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension.  T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th Ed.) - 2003
C8727	Stage_IV_Ovarian_Dysgerminoma	Ovarian_Dysgerminoma|Stage_IV_Ovarian_Germ_Cell_Tumor	Stage IV Ovarian Dysgerminoma	Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes peritoneal metastasis. (AJCC 6th Ed.) - 2003
C8728	Stage_III_Ovarian_Embryonal_Carcinoma	Ovarian_Embryonal_Carcinoma	Stage III Ovarian Embryonal Carcinoma|Ovarian Embryonal Carcinoma, Stage III	Stage III includes: (T3, N0, M0).  Also, IIIA: (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c N0, M0) and (Any T, N1, M0).  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor).  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension.  T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis. N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.) - 2003
C8729	Stage_IV_Ovarian_Embryonal_Carcinoma	Ovarian_Embryonal_Carcinoma	Stage IV Ovarian Embryonal Carcinoma|Ovarian Embryonal Carcinoma Stage IV	Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes peritoneal metastasis. (AJCC 6th Ed.) - 2003
C8730	Stage_I_Ovarian_Choriocarcinoma	Ovarian_Choriocarcinoma|Stage_I_Ovarian_Germ_Cell_Tumor	Stage I Ovarian Choriocarcinoma|Stage I Ovarian Germ Cell Choriocarcinoma	Stage I includes: (T1, N0, M0). Also, IA: (T1a, N0, M0); IB: (T1b, N0, M0); IC (T1c, N0, M0). T1: Tumor limited to ovaries (one or both).  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1b: Tumor limited to one or both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.)-2003
C8731	Stage_II_Ovarian_Choriocarcinoma	Ovarian_Choriocarcinoma|Stage_II_Ovarian_Germ_Cell_Tumor	Stage II Ovarian Choriocarcinoma|Ovarian Germ Cell Choriocarcinoma Stage II|Ovarian Germ Cell Choriocarcinoma, Stage II|Stage II Ovarian Germ Cell Choriocarcinoma	Stage II includes: (T2, N0, M0).  Also, IIA: (T2a, N0, M0); IIB: (T2b, N0, M0); IIC: (T2c, N0, M0).  T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  T2a: Extension and/or implants on uterus and/or tube(s).  No malignant cells in ascites or peritoneal washings.  T2b: Extension to and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  T2c: Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washings.  N0: No regional metastasis. (AJCC 6th Ed.) - 2003
C8732	Stage_III_Ovarian_Choriocarcinoma	Ovarian_Choriocarcinoma|Stage_III_Ovarian_Germ_Cell_Tumor	Stage III Ovarian Choriocarcinoma|Ovarian Germ Cell Choriocarcinoma Stage III|Ovarian Germ Cell Choriocarcinoma, Stage III|Stage III Ovarian Germ Cell Choriocarcinoma	Stage III includes: (T3, N0, M0).  Also, IIIA: (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c N0, M0) and (Any T, N1, M0).  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor).  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension.  T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th Ed.) - 2003
C8733	Stage_IV_Ovarian_Choriocarcinoma	Ovarian_Choriocarcinoma|Stage_IV_Ovarian_Germ_Cell_Tumor	Stage IV Ovarian Choriocarcinoma|Ovarian Germ Cell Choriocarcinoma Stage IV|Ovarian Germ Cell Choriocarcinoma, Stage IV|Stage IV Ovarian Germ Cell Choriocarcinoma	Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes peritoneal metastasis. (AJCC 6th Ed.) - 2003
C8734	Stage_I_Ovarian_Embryonal_Carcinoma	Ovarian_Embryonal_Carcinoma	Stage I Ovarian Embryonal Carcinoma|Ovarian Embryonal Carcinoma, Stage I	Stage I includes: (T1, N0, M0). Also, IA: (T1a, N0, M0); IB: (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor limited to ovaries (one or both).  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1b: Tumor limited to one or both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.) - 2003
C8735	Stage_I_Ovarian_Yolk_Sac_Tumor	Ovarian_Yolk_Sac_Tumor	Stage I Ovarian Yolk Sac Tumor|Ovarian Yolk Sac Tumor Stage I|Yolk Sac Tumor of Ovary Stage I|Yolk Sac Tumor of the Ovary Stage I	Stage I includes: (T1, N0, M0). Also, IA: (T1a, N0, M0); IB: (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor limited to ovaries (one or both).  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1b: Tumor limited to one or both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.) - 2003
C8736	Stage_II_Ovarian_Yolk_Sac_Tumor	Ovarian_Yolk_Sac_Tumor	Stage II Ovarian Yolk Sac Tumor|Ovarian Yolk Sac Tumor Stage II|Yolk Sac Tumor of Ovary Stage II|Yolk Sac Tumor of the Ovary Stage II	Stage II includes: (T2, N0, M0).  Also, IIA: (T2a, N0, M0); IIB: (T2b, N0, M0); IIC: (T2c, N0, M0).  T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  T2a: Extension and/or implants on uterus and/or tube(s).  No malignant cells in ascites or peritoneal washings.  T2b: Extension to and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  T2c: Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washings.  N0: No regional metastasis. (AJCC 6th Ed.) - 2003
C8737	Stage_III_Ovarian_Yolk_Sac_Tumor	Ovarian_Yolk_Sac_Tumor	Stage III Ovarian Yolk Sac Tumor|Ovarian Yolk Sac Tumor Stage III|Yolk Sac Tumor of Ovary Stage III|Yolk Sac Tumor of the Ovary Stage III	Stage III includes: (T3, N0, M0).  Also, IIIA: (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c N0, M0) and (Any T, N1, M0).  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor).  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension.  T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th Ed.) - 2003
C8738	Stage_IV_Ovarian_Yolk_Sac_Tumor	Ovarian_Yolk_Sac_Tumor	Stage IV Ovarian Yolk Sac Tumor|Ovarian Yolk Sac Tumor Stage IV|Yolk Sac Tumor of Ovary Stage IV|Yolk Sac Tumor of the Ovary Stage IV	Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes peritoneal metastasis. (AJCC 6th Ed.) - 2003
C8739	Stage_I_Ovarian_Polyembryoma	Polyembryoma_of_the_Ovary|Stage_I_Ovarian_Germ_Cell_Tumor	Stage I Ovarian Polyembryoma|Ovarian Polyembryoma Stage I	Stage I includes: (T1, N0, M0). Also, IA: (T1a, N0, M0); IB: (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor limited to ovaries (one or both).  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1b: Tumor limited to one or both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.) - 2003
C8740	Stage_II_Ovarian_Polyembryoma	Polyembryoma_of_the_Ovary|Stage_II_Ovarian_Germ_Cell_Tumor	Stage II Ovarian Polyembryoma|Ovarian Polyembryoma Stage II	Stage II includes: (T2, N0, M0).  Also, IIA: (T2a, N0, M0); IIB: (T2b, N0, M0); IIC: (T2c, N0, M0).  T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  T2a: Extension and/or implants on uterus and/or tube(s).  No malignant cells in ascites or peritoneal washings.  T2b: Extension to and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  T2c: Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washings.  N0: No regional metastasis.  (AJCC 6th Ed.) - 2003
C8741	Stage_III_Ovarian_Polyembryoma	Polyembryoma_of_the_Ovary|Stage_III_Ovarian_Germ_Cell_Tumor	Stage III Ovarian Polyembryoma|Ovarian Polyembryoma Stage III	Stage III includes: (T3, N0, M0).  Also, IIIA: (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c N0, M0) and (Any T, N1, M0).  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor).  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension.  T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th Ed.) - 2003
C8742	Stage_IV_Ovarian_Polyembryoma	Polyembryoma_of_the_Ovary|Stage_IV_Ovarian_Germ_Cell_Tumor	Stage IV Ovarian Polyembryoma|Ovarian Polyembryoma Stage IV	Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes peritoneal metastasis. (AJCC 6th Ed.) - 2003
C8743	Stage_I_Ovarian_Teratoma	Ovarian_Teratoma|Stage_I_Ovarian_Germ_Cell_Tumor	Stage I Ovarian Teratoma|Stage I Ovarian Germ Cell Teratoma	Stage I includes: (T1, N0, M0). Also, IA: (T1a, N0, M0); IB: (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor limited to ovaries (one or both).  T1a: Tumor limited to one ovary; capsule intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1b: Tumor limited to one or both ovaries; capsules intact, no tumor on ovarian surface.  No malignant cells in ascites or peritoneal washings.  T1c: Tumor limited to one or both ovaries with any of the following: capsule ruptured, tumor on ovarian surface, malignant cells in ascites or peritoneal washings.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th Ed.) - 2003
C8744	Stage_II_Ovarian_Teratoma	Ovarian_Teratoma|Stage_II_Ovarian_Germ_Cell_Tumor	Stage II Ovarian Teratoma|Ovarian Germ Cell Teratoma Stage II|Ovarian Germ Cell Teratoma, Stage II|Stage II Ovarian Germ Cell Teratoma	Stage II includes: (T2, N0, M0).  Also, IIA: (T2a, N0, M0); IIB: (T2b, N0, M0); IIC: (T2c, N0, M0).  T2: Tumor involves one or both ovaries with pelvic extension and/or implants.  T2a: Extension and/or implants on uterus and/or tube(s).  No malignant cells in ascites or peritoneal washings.  T2b: Extension to and/or implants on other pelvic tissues.  No malignant cells in ascites or peritoneal washings.  T2c: Pelvic extension and/or implants (T2a or T2b) with malignant cells in ascites or peritoneal washings.  N0: No regional metastasis.  (AJCC 6th Ed.) - 2003
C8745	Stage_III_Ovarian_Teratoma	Ovarian_Teratoma|Stage_III_Ovarian_Germ_Cell_Tumor	Stage III Ovarian Teratoma|Ovarian Germ Cell Teratoma Stage III|Ovarian Germ Cell Teratoma, Stage III|Stage III Ovarian Germ Cell Teratoma	Stage III includes: (T3, N0, M0).  Also, IIIA: (T3a, N0, M0); IIIB (T3b, N0, M0); IIIC (T3c N0, M0) and (Any T, N1, M0).  T3: Tumor involves one or both ovaries with microscopically confirmed peritoneal metastasis outside the pelvis.  T3a: Microscopic peritoneal metastasis beyond pelvis (no macroscopic tumor).  T3b: Macroscopic peritoneal metastasis beyond pelvis 2 cm or less in greatest dimension.  T3c: Peritoneal metastasis beyond pelvis more than 2cm in greatest dimension and/or regional lymph node metastasis.  N0: No regional lymph node metastasis.  N1: Regional lymph node metastasis.  M0: No distant metastasis.  (AJCC 6th Ed.) - 2003
C8746	Stage_IV_Ovarian_Teratoma	Ovarian_Teratoma|Stage_IV_Ovarian_Germ_Cell_Tumor	Stage IV Ovarian Teratoma|Ovarian Germ Cell Teratoma Stage IV|Ovarian Germ Cell Teratoma, Stage IV|Stage IV Ovarian Germ Cell Teratoma	Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes peritoneal metastasis. (AJCC 6th Ed.) - 2003
C8747	Recurrent_Adenosquamous_Cell_Lung_Carcinoma	Adenosquamous_Lung_Carcinoma|Recurrent_Non-Small_Cell_Lung_Cancer	Recurrent Adenosquamous Lung Carcinoma|Adenosquamous Cell Lung Carcinoma Recurrent|Recurrent Adenosquamous Cell Carcinoma of Lung|Recurrent Adenosquamous Cell Carcinoma of the Lung|Recurrent Adenosquamous Cell Lung Carcinoma	The re-emergence of adenosquamous lung carcinoma after a period of remission. (NCI05)
C8748	Stage_0_Adenosquamous_Lung_Carcinoma	Adenosquamous_Lung_Carcinoma|Stage_0_Non-Small_Cell_Lung_Cancer	Stage 0 Adenosquamous Lung Carcinoma|Adenosquamous Cell Carcinoma in situ of Lung|Adenosquamous Cell Carcinoma in situ of the Lung|Lung Adenosquamous Cell Carcinoma in situ|Stage 0 Adenosquamous Cell Carcinoma of Lung|Stage 0 Adenosquamous Cell Carcinoma of the Lung|Stage 0 Adenosquamous Cell Lung Carcinoma	A non-small cell lung cancer (NSCLC), histologically classified as adenosquamous carcinoma.  Carcinoma in situ with no regional lymph node metastasis and no distant metastasis (Tis, N0, M0). (AJCC 6th Ed.) - 2003
C8749	Stage_I_Adenosquamous_Lung_Carcinoma	Adenosquamous_Lung_Carcinoma	Stage I Adenosquamous Lung Carcinoma|Stage I Adenosquamous Cell Carcinoma of Lung|Stage I Adenosquamous Cell Carcinoma of the Lung|Stage I Adenosquamous Cell Lung Carcinoma	A non-small cell lung cancer (NSCLC), histologically classified as adenosquamous carcinoma.  No regional lymph node or distant metastases.  Tumor size and aggressiveness vary.  Subclassified as Stage IA (T1, N0, M0) or Stage IB (T2, N0, M0).  T1: Tumor is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura, and without bronchoscopic evidence of invasion more proximal than the lobar bronchus, with neither regional lymph node nor distant metastases.  T2: Tumor has any of the following features of size or extent: more than 3 cm in greatest dimension; involves the main bronchus, 2 cm or more distal to the carina; invades the visceral pleura; associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung.  (AJCC 6th Ed.) - 2003
C8750	Stage_II_Adenosquamous_Lung_Carcinoma	Adenosquamous_Lung_Carcinoma	Stage II Adenosquamous Lung Carcinoma|Stage II Adenosquamous Cell Carcinoma of Lung|Stage II Adenosquamous Cell Carcinoma of the Lung|Stage II Adenosquamous Cell Lung Carcinoma
C8751	Stage_III_Adenosquamous_Lung_Carcinoma	Adenosquamous_Lung_Carcinoma	Stage III Adenosquamous Lung Carcinoma|Stage III Adenosquamous Cell Carcinoma of Lung|Stage III Adenosquamous Cell Carcinoma of the Lung|Stage III Adenosquamous Cell Lung Carcinoma
C8752	Stage_IV_Adenosquamous_Lung_Carcinoma	Adenosquamous_Lung_Carcinoma	Stage IV Adenosquamous Lung Carcinoma|Metastatic Adenosquamous Cell Carcinoma of Lung|Metastatic Adenosquamous Cell Carcinoma of the Lung|Metastatic Adenosquamous Cell Lung Carcinoma|Stage IV Adenosquamous Cell Carcinoma of Lung|Stage IV Adenosquamous Cell Carcinoma of the Lung|Stage IV Adenosquamous Cell Lung Carcinoma	A non-small cell lung cancer (NSCLC), histologically classified as adenosquamous carcinoma.  Distant metastasis is present.  Tumor can be of any size and aggressiveness, with any degree of regional lymph node metastasis (Any T, Any N, M1).  (AJCC 6th Ed.) - 2003
C8753	Recurrent_Large_Cell_Lung_Carcinoma	Recurrent_Non-Small_Cell_Lung_Cancer	Recurrent Large Cell Lung Carcinoma|Recurrent Large Cell Carcinoma of Lung|Recurrent Large Cell Carcinoma of the Lung|Relapsed Large Cell Carcinoma of Lung|Relapsed Large Cell Carcinoma of the Lung|Relapsed Large Cell Lung Carcinoma	The re-emergence of large cell lung carcinoma after a period of remission. (NCI05)
C8755	Stage_I_Large_Cell_Lung_Carcinoma	Large_Cell_Lung_Carcinoma|Stage_I_Non-Small_Cell_Lung_Cancer	Stage I Large Cell Lung Carcinoma|Stage I Large Cell Carcinoma of Lung|Stage I Large Cell Carcinoma of the Lung	A non-small cell lung cancer (NSCLC), histologically classified as large cell carcinoma.  No regional lymph node or distant metastases.  Tumor size and aggressiveness vary.  Subclassified as Stage IA (T1,N0,M0) or Stage IB (T2,N0,M0).  T1: tumor is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura, and without bronchoscopic evidence of invasion more proximal than the lobar bronchus, with neither regional lymph node nor distant metastases.  T2: tumor has any of the following features of size or extent: more than 3 cm in greatest dimension; involves the main bronchus, 2 cm or more distal to the carina; invades the visceral pleura; associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung.
C8756	Stage_IV_Large_Cell_Lung_Carcinoma	Large_Cell_Lung_Carcinoma|Stage_IV_Non-Small_Cell_Lung_Cancer	Stage IV Large Cell Lung Carcinoma|Stage IV Large Cell Carcinoma of Lung|Stage IV Large Cell Carcinoma of the Lung	A non-small cell lung cancer (NSCLC), histologically classified as large cell cell carcinoma.  Distant metastasis is present.  Tumor can be of any size and aggressiveness, with any degree of regional lymph node metastasis (Any T, Any N, M1).
C8757	Recurrent_Lung_Adenocarcinoma	Lung_Adenocarcinoma|Recurrent_Non-Small_Cell_Lung_Cancer	Recurrent Lung Adenocarcinoma|Lung Adenocarcinoma, Recurrent|Recurrent Adenocarcinoma of Lung|Recurrent Adenocarcinoma of the Lung	The re-emergence of lung adenocarcinoma after a period of remission. (NCI05)
C8758	Stage_0_Lung_Adenocarcinoma	Adenocarcinoma_in_situ|Lung_Adenocarcinoma|Stage_0_Non-Small_Cell_Lung_Cancer	Stage 0 Lung Adenocarcinoma|Adenocarcinoma in situ of Lung|Adenocarcinoma in situ of the Lung|Lung Adenocarcinoma in situ|Lung Adenocarcinoma, Stage 0|Stage 0 Adenocarcinoma of Lung|Stage 0 Adenocarcinoma of the Lung	A non-small cell lung cancer (NSCLC), histologically classified as adenocarcinoma.  Carcinoma in situ with no regional lymph node metastasis and no distant metastasis (Tis, N0, M0) (AJCC 6th Ed.) - 2003
C8759	Stage_I_Lung_Adenocarcinoma	Lung_Adenocarcinoma|Stage_I_Non-Small_Cell_Lung_Cancer	Stage I Lung Adenocarcinoma|Lung Adenocarcinoma, Stage I|Stage I Adenocarcinoma of Lung|Stage I Adenocarcinoma of the Lung	A non-small cell lung cancer (NSCLC), histologically classified as adenocarcinoma.  No regional lymph node or distant metastases.  Tumor size and aggressiveness vary.  Subclassified as Stage IA (T1, N0, M0) or Stage IB (T2, N0, M0).  T1: tumor is 3 cm or less in greatest dimension, surrounded by lung or visceral pleura, without bronchoscopic evidence of invasion more proximal than the lobar bronchus, with neither regional lymph node nor distant metastases.  T2: tumor has any of the following features of size or extent: more than 3 cm in greatest dimension; involves the main bronchus, 2 cm or more distal to the carina; invades the visceral pleura; associated with atelectasis or obstructive pneumonitis that extends to the hilar region but does not involve the entire lung.  (AJCC 6th Ed.) - 2003
C8760	Stage_II_Lung_Adenocarcinoma	Lung_Adenocarcinoma|Stage_II_Non-Small_Cell_Lung_Cancer	Stage II Lung Adenocarcinoma|Lung Adenocarcinoma Stage II|Lung Adenocarcinoma, Stage II|Stage II Adenocarcinoma of Lung|Stage II Adenocarcinoma of the Lung
C8761	Stage_III_Lung_Adenocarcinoma	Lung_Adenocarcinoma|Stage_III_Non-Small_Cell_Lung_Cancer	Stage III Lung Adenocarcinoma|Lung Adenocarcinoma Stage III|Lung Adenocarcinoma, Stage III|Stage III Adenocarcinoma of Lung|Stage III Adenocarcinoma of the Lung
C8762	Stage_IV_Lung_Adenocarcinoma	Lung_Adenocarcinoma|Stage_IV_Non-Small_Cell_Lung_Cancer	Stage IV Lung Adenocarcinoma|Lung Adenocarcinoma, Stage IV|Metastatic Adenocarcinoma of Lung|Metastatic Adenocarcinoma of the Lung|Metastatic Lung Adenocarcinoma|Stage IV Adenocarcinoma of Lung|Stage IV Adenocarcinoma of the Lung	A non-small cell lung cancer (NSCLC), histologically classified as adenocarcinoma.  Distant metastasis is present.  Tumor can be of any size and aggressiveness, with any degree of regional lymph node metastasis (Any T, Any N, M1).  (AJCC 6th Ed.) - 2003
C8763	Stage_0_Squamous_Cell_Lung_Carcinoma	Squamous_Cell_Lung_Carcinoma|Stage_0_Squamous_Cell_Carcinoma	Stage 0 Squamous Cell Lung Carcinoma|Epidermoid Cell Carcinoma in situ of Lung|Epidermoid Cell Carcinoma in situ of the Lung|Lung Epidermoid Cell Carcinoma in situ|Lung Squamous Cell Carcinoma in situ|Squamous Cell Carcinoma in situ of Lung|Squamous Cell Carcinoma in situ of the Lung|Stage 0 Epidermoid Cell Carcinoma of Lung|Stage 0 Epidermoid Cell Carcinoma of the Lung|Stage 0 Epidermoid Cell Lung Carcinoma|Stage 0 Squamous Cell Carcinoma of Lung|Stage 0 Squamous Cell Carcinoma of the Lung	Stage 0 includes: Tis, N0, M0. Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C8764	Stage_I_Squamous_Cell_Lung_Carcinoma	Squamous_Cell_Lung_Carcinoma	Stage I Squamous Cell Lung Carcinoma|Stage I Epidermoid Cell Carcinoma of Lung|Stage I Epidermoid Cell Carcinoma of the Lung|Stage I Epidermoid Cell Lung Carcinoma|Stage I Squamous Cell Carcinoma of Lung|Stage I Squamous Cell Carcinoma of the Lung	Stage I includes: IA (T1, N0, M0); IB (T2, N0, M0).  T1: Tumor 3cm or less in greatest dimension, surrounded by lung or visceral pleura, without bronchoscopic evidence of invasion more proximal than the lobar bronchus, (i.e. not in the main bronchus).  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C8765	Stage_II_Squamous_Cell_Lung_Carcinoma	Squamous_Cell_Lung_Carcinoma	Stage II Squamous Cell Lung Carcinoma|Lung Squamous Cell Carcinoma Stage II|Stage II Epidermoid Cell Carcinoma of Lung|Stage II Epidermoid Cell Carcinoma of the Lung|Stage II Epidermoid Cell Lung Carcinoma|Stage II Squamous Cell Carcinoma of Lung|Stage II Squamous Cell Carcinoma of the Lung
C8766	Stage_III_Squamous_Cell_Lung_Carcinoma	Squamous_Cell_Lung_Carcinoma	Stage III Squamous Cell Lung Carcinoma|Lung Squamous Cell Carcinoma Stage III|Stage III Epidermoid Cell Carcinoma of Lung|Stage III Epidermoid Cell Carcinoma of the Lung|Stage III Epidermoid Cell Lung Carcinoma|Stage III Squamous Cell Carcinoma of Lung|Stage III Squamous Cell Carcinoma of the Lung
C8767	Stage_IV_Squamous_Cell_Lung_Carcinoma	Squamous_Cell_Lung_Carcinoma	Stage IV Squamous Cell Lung Carcinoma|Metastatic Epidermoid Cell Carcinoma of Lung|Metastatic Epidermoid Cell Carcinoma of the Lung|Metastatic Epidermoid Cell Lung Carcinoma|Metastatic Squamous Cell Carcinoma of Lung|Metastatic Squamous Cell Carcinoma of the Lung|Metastatic Squamous Cell Lung Carcinoma|Stage IV Epidermoid Cell Carcinoma of Lung|Stage IV Epidermoid Cell Carcinoma of the Lung|Stage IV Epidermoid Cell Lung Carcinoma|Stage IV Squamous Cell Carcinoma of Lung|Stage IV Squamous Cell Carcinoma of the Lung	Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis is present.  (AJCC 6th ed.) - 2003
C8768	Stage_I_Pharyngeal_Cancer	Pharyngeal_Carcinoma	Stage I Pharyngeal Cancer|Pharyngeal Cancer Stage I	Stage 1 includes T1, N0, M0. T1: Tumor confined to the nasopharynx.
C8769	Stage_II_Pharyngeal_Cancer	Pharyngeal_Carcinoma	Stage II Pharyngeal Cancer|Pharyngeal Cancer Stage II|Stage II Carcinoma of Pharynx|Stage II Carcinoma of the Pharynx|Stage II Pharyngeal Carcinoma|Stage II Pharynx Carcinoma	Stage 2 includes T2a,T2b,N0,M0/T1,T2,T2a,T2b,N1,M0.  T2: Tumor extends to soft tissues of oropharynx and/or nasal fossa.  T2a: without parapharyngeal extension.  T2b: with parapharyngeal extension.  N1: Unilateral metastasis in lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa.
C8770	Stage_III_Pharyngeal_Cancer	Pharyngeal_Carcinoma	Stage III Pharyngeal Cancer|Pharyngeal Cancer Stage III|Stage III Carcinoma of Pharynx|Stage III Carcinoma of the Pharynx|Stage III Pharyngeal Carcinoma|Stage III Pharynx Carcinoma	Stage 3 includes T1,T2a,T2b,N2,M0/T3,N0,N1,N2,M0. T3: Tumor invades bony structures and/or paranasal sinuses.  N2: Bilateral metastasis in lymph node(s), 6 cm or less in greatest dimension, above the supraclavicular fossa.
C8771	Stage_IV_Pharyngeal_Cancer	Pharyngeal_Carcinoma	Stage IV Pharyngeal Cancer|Metastatic Carcinoma of Pharynx|Metastatic Carcinoma of the Pharynx|Metastatic Pharyngeal Carcinoma|Metastatic Pharynx Carcinoma|Pharyngeal Cancer Stage IV|Stage IV Carcinoma of Pharynx|Stage IV Carcinoma of the Pharynx|Stage IV Pharyngeal Carcinoma|Stage IV Pharynx Carcinoma	Stage 4 includes T4,N0,N1,N2,M0/anyT,N3,M0/anyT,anyN,M1. T4: Tumor with intracranial extension and/or involvement of cranial nerves, infratemporal fossa, hypopharynx, or orbit.  N3: Metastasis in a lymph node(s).  M1: Distant metastasis.
C8772	Stage_I_Lung_Cancer	Lung_Carcinoma	Stage I Lung Cancer|Stage I Carcinoma of Lung|Stage I Carcinoma of the Lung|Stage I Lung Carcinoma	Stage I includes: IA: (TI, N0, M0) and IB: (T2, N0, M0).  TI: Tumor 3 cm or less in greatest dimension surrounded by lung or visceral pleura, without bronchoscopic evidence of invasion more proximal than the lobar bronchus.  T2: Tumor with any of the following features of size or extent: More than 3cm in greatest dimension.  Involves main bronchus, 2cm or more distal to the carina.  Invades the visceral pleura.  N0: No regional lymph metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C8773	Stage_III_Lung_Cancer	Lung_Carcinoma	Stage III Lung Cancer|Stage III Carcinoma of Lung|Stage III Carcinoma of the Lung|Stage III Lung Carcinoma
C8774	Stage_IV_Lung_Cancer	Lung_Carcinoma	Stage IV Lung Cancer|Metastatic Carcinoma of Lung|Metastatic Carcinoma of the Lung|Metastatic Lung Carcinoma|Stage IV Carcinoma of Lung|Stage IV Carcinoma of the Lung|Stage IV Lung Carcinoma|Unspecified Stage IV Carcinoma of Lung|Unspecified Stage IV Carcinoma of the Lung	Stage IV includes: Any T, Any N, M1.  M1: Distant metastasis present. (AJCC 6th ed.) - 2003
C8776	Peripheral_Neuroectodermal_Tumor_of_Bone	Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor_of_Bone|Peripheral_Primitive_Neuroectodermal_Tumor	Peripheral Primitive Neuroectodermal Tumor of Bone|Bone Peripheral Neuroepithelioma|Osseous Peripheral Neuroepithelioma|Peripheral Neuroectodermal Tumor of Bone|Peripheral Neuroectodermal Tumor of the Bone|Peripheral Neuroepithelioma of Bone|Peripheral Neuroepithelioma of the Bone
C8778	Localized_Chondrosarcoma	Chondrosarcoma	Localized Chondrosarcoma|Chondrosarcoma, Localized	A non-disseminated skeletal or extraskeletal chondrosarcoma. --2004
C8779	Metastatic_Chondrosarcoma	Chondrosarcoma	Metastatic Chondrosarcoma|Chondrosarcoma, Metastatic	Chondrosarcoma that spreads to a secondary site
C8780	Recurrent_Chondrosarcoma	Chondrosarcoma	Recurrent Chondrosarcoma|Chondrosarcoma, Recurrent|Relapsed Chondrosarcoma	The reemergence of chondrosarcoma that was in remission
C8781	Stage_I_Acral_Lentiginous_Melanoma	Acral_Lentiginous_Malignant_Melanoma	Stage I Acral Lentiginous Melanoma	Stage I includes: IA (T1a, N0, M0); IB (T1b, N0, M0); (T2a, N0, M0).  T1a: Melanoma is less than or equal to 1.0mm in thickness with or without ulceration.  T1b: Melanoma is less than or equal to 1.0mm in thickness and level IV or V with ulceration.  T2a: Melanoma 1.01-2.0 - mm in thickness, no ulceration.  N0: No regional lymph node metastasis.  M0: No distant metastasis. - 2003
C8782	Stage_II_Acral_Lentiginous_Melanoma	Acral_Lentiginous_Malignant_Melanoma	Stage II Acral Lentiginous Melanoma	Stage II includes: IIA (T2b, N0, M0); (T3a, N0, M0); IIB (T3b, N0, M0); (T4a, N0, M0); IIC (T4b, N0, M0).  T2b: Melanoma 1.01 - 2.0mm in thickness, with ulceration. T3a: Melanoma 2.01 - 4.0mm in thickness, no ulceration.  T3b: Melanoma 2.01 - 4.0mm in thickness, with ulceration.  T4a: Melanoma is greater than 4.0 mm in thickness, no ulceration.  T4b: Melanoma is greater than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastasis.  M0: No distant metastasis. - 2003
C8783	Stage_III_Acral_Lentiginous_Melanoma	Acral_Lentiginous_Malignant_Melanoma	Stage III Acral Lentiginous Melanoma	Stage III includes: (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0).  N1: Metastasis in one lymph node.  N2: Metastasis in two to three regional lymph nodes or intralymphatic regional metastasis without nodal metastases.  N3: Metastasis in four or more regional nodes, or matted metastatic nodes, or in-transit metastasis or satellite(s) with metastasis in regional node(s). - 2003
C8784	Stage_IV_Acral_Lentiginous_Melanoma	Acral_Lentiginous_Malignant_Melanoma	Stage IV Acral Lentiginous Melanoma	Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. - 2003
C8785	Recurrent_Lentigo_Maligna_Melanoma	Lentigo_Maligna_Melanoma|Recurrent_Melanoma_of_the_Skin	Recurrent Lentigo Maligna Melanoma|Lentigo Maligna Recurrent	The reemergence of lentigo maligna after a period of remission
C8786	Stage_I_Lentigo_Maligna_Melanoma	Lentigo_Maligna_Melanoma	Stage I Lentigo Maligna Melanoma|Stage I Lentigo Maligna
C8787	Stage_II_Lentigo_Maligna_Melanoma	Lentigo_Maligna_Melanoma	Stage II Lentigo Maligna Melanoma|Stage II Lentigo Maligna
C8788	Stage_III_Lentigo_Maligna_Melanoma	Lentigo_Maligna_Melanoma	Stage III Lentigo Maligna Melanoma|Stage III Lentigo Maligna
C8789	Stage_IV_Lentigo_Maligna_Melanoma	Lentigo_Maligna_Melanoma	Stage IV Lentigo Maligna Melanoma|Stage IV Lentigo Maligna
C8790	Stage_I_Superficial_Spreading_Melanoma	Superficial_Spreading_Melanoma_of_the_Skin	Stage I Superficial Spreading Melanoma	Stage I includes: IA (T1a, N0, M0); IB (T1b, N0, M0); (T2a, N0, M0). T1a: Melanoma is less than or equal to 1.0mm in thickness with or without ulceration. T1b: Melanoma is less than or equal to 1.0mm in thickness and level IV or V with ulceration. T2a: Melanoma 1.01-2.0 - mm in thickness, no ulceration. N0: No regional lymph node metastasis. M0: No distant metastasis. - 2003
C8791	Stage_II_Superficial_Spreading_Melanoma	Superficial_Spreading_Melanoma_of_the_Skin	Stage II Superficial Spreading Melanoma	Stage II includes: IIA (T2b, N0, M0); (T3a, N0, M0); IIB (T3b, N0, M0); (T4a, N0, M0); IIC (T4b, N0, M0).  T2b: Melanoma 1.01 - 2.0mm in thickness, with ulceration.  T3a: Melanoma 2.01 - 4.0mm in thickness, no ulceration.  T3b: Melanoma 2.01 - 4.0mm in thickness, with ulceration.  T4a: Melanoma is greater than 4.0 mm in thickness, no ulceration.  T4b: Melanoma is greater than 4.0 mm in thickness, with ulceration.  N0: No regional lymph node metastasis.  M0: No distant metastasis. - 2003
C8792	Stage_III_Superficial_Spreading_Melanoma	Superficial_Spreading_Melanoma_of_the_Skin	Stage III Superficial Spreading Melanoma	Stage III includes: (Any T, N1, M0); (Any T, N2, M0); (Any T, N3, M0).  N1: Metastasis in one lymph node.  N2: Metastasis in two to three regional lymph nodes or intralymphatic regional metastasis without nodal metastases. N3: Metastasis in four or more regional nodes, or matted metastatic nodes, or in-transit metastasis or satellite(s) with metastasis in regional node(s). - 2003
C8793	Stage_IV_Superficial_Spreading_Melanoma	Superficial_Spreading_Melanoma_of_the_Skin	Stage IV Superficial Spreading Melanoma	Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. - 2003
C8795	Recurrent_Malignant_Fibrous_Histiocytoma	Malignant_Fibrous_Histiocytoma	Recurrent Malignant Fibrous Histiocytoma|Malignant Fibrous Histiocytoma Recurrent|Relapsed Malignant Fibrous Histiocytoma	Reemergence of malignant fibrous histiocytoma after a period of remission
C8796	Metastatic_Alveolar_Soft_Part_Sarcoma	Alveolar_Soft_Part_Sarcoma	Metastatic Alveolar Soft Part Sarcoma|Alveolar Soft Part Sarcoma Metastatic	Alveolar soft part sarcoma spreading to another site
C8797	Primary_Alveolar_Soft_Part_Sarcoma	Alveolar_Soft_Part_Sarcoma	Primary Alveolar Soft Part Sarcoma|Alveolar Soft Part Sarcoma Nonmetastatic|Non-Metastatic Alveolar Soft Part Sarcoma	Alveolar soft part sarcoma not spreading from its primary site
C8798	Recurrent_Alveolar_Soft_Part_Sarcoma	Alveolar_Soft_Part_Sarcoma	Recurrent Alveolar Soft Part Sarcoma|Alveolar Soft Part Sarcoma Recurrent|Relapsed Alveolar Soft Part Sarcoma	The reemergence of alveolar soft part sarcoma after a period of remission
C8799	Metastatic_Epithelioid_Sarcoma	Epithelioid_Sarcoma	Metastatic Epithelioid Sarcoma|Epithelioid Sarcoma, Metastatic|Metastatic Epithelioid Cell Sarcoma
C8800	Primary_Epithelioid_Sarcoma	Epithelioid_Sarcoma	Primary Epithelioid Sarcoma|Epithelioid Sarcoma, Nonmetastatic|Non-Metastatic Epithelioid Cell Sarcoma|Non-Metastatic Epithelioid Sarcoma
C8801	Metastatic_Extraosseous_Ewing_s_Sarcoma	Extraosseous_Ewing_s_Sarcoma|Metastatic_Ewing_s_Sarcoma	Metastatic Extraosseous Ewing's Sarcoma|Extra-Osseous Ewing's Sarcoma, Metastatic|Metastatic Extra-Osseous Ewing's Sarcoma|Metastatic Extraskeletal Ewing's Sarcoma
C8802	Non-Metastatic_Extraosseous_Ewing_s_Sarcoma	Extraosseous_Ewing_s_Sarcoma	Non-Metastatic Extraosseous Ewing's Sarcoma|Extra-Osseous Ewing's Sarcoma, Nonmetastatic|Non-Metastatic Extra-Osseous Ewing's Sarcoma|Non-Metastatic Extraskeletal Ewing's Sarcoma
C8803	Recurrent_Extraosseous_Ewing_s_Sarcoma	Extraosseous_Ewing_s_Sarcoma|Recurrent_Ewing_s_Sarcoma	Recurrent Extraosseous Ewing's Sarcoma|Extra-Osseous Ewing's Sarcoma, Recurrent|Recurrent Extra-Osseous Ewing's Sarcoma|Recurrent Extraskeletal Ewing's Sarcoma|Relapsed Extra-Osseous Ewing's Sarcoma	Reemergence of extra-osseous ewing's sarcoma after a period of remission
C8804	Metastatic_Extraskeletal_Chondrosarcoma	Extraskeletal_Chondrosarcoma|Metastatic_Chondrosarcoma	Metastatic Extraskeletal Chondrosarcoma|Extraskeletal Chondrosarcoma, Metastatic|Metastatic Extraosseous Chondrosarcoma
C8806	Extraskeletal_Chondrosarcoma	Chondrosarcoma|Malignant_Extraskeletal_Cartilaginous_and_Osseous_Neoplasm	Extraskeletal Chondrosarcoma|Extraosseous Chondrosarcoma
C8807	Recurrent_Extraskeletal_Chondrosarcoma	Extraskeletal_Chondrosarcoma|Recurrent_Chondrosarcoma	Recurrent Extraskeletal Chondrosarcoma|Extraskeletal Chondrosarcoma, Recurrent|Recurrent Extraosseous Chondrosarcoma|Relapsed Extraskeletal Chondrosarcoma	Reemergence of extraskeletal chondrosarcoma after a period of remission
C8808	Metastatic_Extraskeletal_Osteosarcoma	Extraskeletal_Osteosarcoma	Metastatic Extraskeletal Osteosarcoma|Extraskeletal Osteosarcoma, Metastatic|Metastatic Extraosseous Osteosarcoma|Metastatic Extraskeletal Osteogenic Sarcoma
C8809	Non-Metastatic_Extraskeletal_Osteosarcoma	Extraskeletal_Osteosarcoma|Non-Metastatic_Neoplasm	Non-Metastatic Extraskeletal Osteosarcoma|Extraskeletal Osteosarcoma, Nonmetastatic|Non-Metastatic Extraosseous Osteosarcoma|Non-Metastatic Extraskeletal Osteogenic Sarcoma
C8810	Extraskeletal_Osteosarcoma	Malignant_Extraskeletal_Cartilaginous_and_Osseous_Neoplasm|Osteosarcoma|Sarcoma_Differentiation_Score_3|Sarcoma_NCI_Grade_3	Extraskeletal Osteosarcoma|Extraosseous Osteosarcoma|Extraskeletal Osteogenic Sarcoma
C8811	Recurrent_Extraskeletal_Osteosarcoma	Extraskeletal_Osteosarcoma	Recurrent Extraskeletal Osteosarcoma|Extraskeletal Osteosarcoma, Recurrent|Recurrent Extraosseous Osteosarcoma|Recurrent Extraskeletal Osteogenic Sarcoma|Relapsed Extraskeletal Osteogenic Sarcoma|Relapsed Extraskeletal Osteosarcoma	Reemergence of extraskeletal osteosarcoma after a period of remission
C8812	Metastatic_Fibrosarcoma	Soft_Tissue_Fibrosarcoma	Metastatic Fibrosarcoma	A fibrosarcoma which has spread from its original location.
C8813	Metastatic_Leiomyosarcoma	Leiomyosarcoma	Metastatic Leiomyosarcoma|Leiomyosarcoma Metastatic	A leiomyosarcoma which has spread from its initial site.
C8814	Primary_Leiomyosarcoma	Leiomyosarcoma	Primary Leiomyosarcoma|Leiomyosarcoma Nonmetastatic|Non-Metastatic Leiomyosarcoma	A leiomyosarcoma which has not spread from its initial site.
C8815	Recurrent_Leiomyosarcoma	Leiomyosarcoma	Recurrent Leiomyosarcoma|Leiomyosarcoma Recurrent|Relapsed Leiomyosarcoma	The reemergence of leiomyosarcoma after a period of remission
C8816	Metastatic_Liposarcoma	Liposarcoma	Metastatic Liposarcoma|Liposarcoma Metastatic	Liposarcoma that has metastasized to a secondary site
C8817	Primary_Liposarcoma	Liposarcoma	Primary Liposarcoma|Liposarcoma Nonmetastatic|Non-Metastatic Liposarcoma	Liposarcoma that does not metastasize to secondary sites
C8818	Recurrent_Liposarcoma	Liposarcoma	Recurrent Liposarcoma|Liposarcoma Recurrent|Relapsed Liposarcoma	The reemergence of liposarcoma after a period of remission
C8822	Metastatic_Malignant_Peripheral_Nerve_Sheath_Tumor	Malignant_Peripheral_Nerve_Sheath_Tumor	Metastatic Malignant Peripheral Nerve Sheath Tumor|Metastatic MPNST	The presence of malignant Schwann cell growth (benign variant is known as neurofibroma) at a site removed from the primary site of tumor growth.
C8823	Recurrent_Malignant_Peripheral_Nerve_Sheath_Tumor	Malignant_Peripheral_Nerve_Sheath_Tumor	Recurrent Malignant Peripheral Nerve Sheath Tumor|Recurrent MPNST|Recurrent Malignant Peripheral Nerve Sheath Neoplasm|Relapsed MPNST|Relapsed Malignant Peripheral Nerve Sheath Neoplasm|Relapsed Malignant Peripheral Nerve Sheath Tumor	A malignant tumor of neural sheath origin-lesions reappearing after an intermission or remission.
C8824	Recurrent_Rhabdomyosarcoma	Rhabdomyosarcoma	Recurrent Rhabdomyosarcoma|Relapsed Rhabdomyosarcoma|Rhabdomyosarcoma Recurrent	The reemergence of rhabdomyosarcoma after a period of remission. - 2003
C8825	Metastatic_Synovial_Sarcoma	Synovial_Sarcoma	Metastatic Synovial Sarcoma|Synovial Sarcoma Metastatic	A synovial sarcoma that has metastasized to other anatomic sites. --2003
C8826	Primary_Synovial_Sarcoma	Synovial_Sarcoma	Primary Synovial Sarcoma|Non-Metastatic Synovial Sarcoma|Synovial Sarcoma Nonmetastatic	Synovial sarcoma affecting an anatomic site as a primary tumor.--2004
C8827	Recurrent_Synovial_Sarcoma	Synovial_Sarcoma	Recurrent Synovial Sarcoma|Relapsed Synovial Sarcoma|Synovial Sarcoma Recurrent	The reemergence of synovial sarcoma after a period of remission
C8828	Recurrent_Hodgkin_s_Disease_Lymphocyte_Predominance_Type	Lymphocyte_Predominant_Type_Hodgkin_s_Disease	Recurrent Hodgkin's Disease Lymphocyte Predominance Type
C8829	Refractory_Hodgkin_s_Disease_Lymphocyte_Predominance_Type	Lymphocyte_Predominant_Type_Hodgkin_s_Disease	Refractory Hodgkin's Disease Lymphocyte Predominance Type
C8830	Stage_III_Hodgkin_s_Disease_Lymphocyte_Predominance_Type	Lymphocyte_Predominant_Type_Hodgkin_s_Disease	Stage III Hodgkin's Disease Lymphocyte Predominance Type	Stage III adult Hodgkin's disease means the involvement of lymph node regions on both sides of the diaphragm (III), which may also be accompanied by localized involvement of an associated extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or by involvement of both (IIIE + S). Stage III disease may be subdivided by anatomic distribution of abdominal involvement or by extent of splenic involvement. Stage III(1) indicates involvement that is limited to the upper abdomen above the renal vein. Stage III(2) indicates involvement of pelvic and/or para-aortic nodes. Five or more visible splenic nodules on a cut section constitutes extensive splenic involvement. Zero to four nodules is classified as minimal splenic disease. (from PDQ)
C8831	Stage_IV_Hodgkin_s_Disease_Lymphocyte_Predominance_Type	Lymphocyte_Predominant_Type_Hodgkin_s_Disease	Stage IV Hodgkin's Disease Lymphocyte Predominance Type	Stage IV adult Hodgkin's disease means there is disseminated (multifocal) involvement of one or more extralymphatic organs, with or without associated lymph node involvement, or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (from PDQ)
C8832	Recurrent_Mixed_Cellularity_Hodgkin_s_Lymphoma	Mixed_Cellularity_Hodgkin_s_Lymphoma|Recurrent_Hodgkin_s_Lymphoma	Recurrent Mixed Cellularity Hodgkin's Lymphoma|Recurrent Mixed Cellularity Hodgkin Lymphoma|Recurrent Mixed Cellularity Hodgkin's Disease|Relapsed Mixed Cellularity Hodgkin's Disease|Relapsed Mixed Cellularity Hodgkin's Lymphoma
C8833	Refractory_Mixed_Cellularity_Hodgkin_s_Lymphoma	Mixed_Cellularity_Hodgkin_s_Lymphoma|Refractory_Hodgkin_s_Lymphoma	Refractory Mixed Cellularity Hodgkin's Lymphoma
C8834	Stage_I_Mixed_Cellularity_Hodgkin_s_Lymphoma	Mixed_Cellularity_Hodgkin_s_Lymphoma|Stage_I_Hodgkin_s_Lymphoma	Stage I Mixed Cellularity Hodgkin's Lymphoma|Mixed Cellularity Hodgkin's Disease Stage I|Mixed Cellularity Hodgkin's Lymphoma Stage I|Stage I Mixed Cellularity Hodgkin Lymphoma|Stage I Mixed Cellularity Hodgkin's Disease	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C8835	Stage_IV_Mixed_Cellularity_Hodgkin_s_Lymphoma	Mixed_Cellularity_Hodgkin_s_Lymphoma|Stage_IV_Hodgkin_s_Lymphoma	Stage IV Mixed Cellularity Hodgkin's Lymphoma|Mixed Cellularity Hodgkin's Disease Stage IV|Mixed Cellularity Hodgkin's Lymphoma Stage IV|Stage IV Mixed Cellularity Hodgkin Lymphoma|Stage IV Mixed Cellularity Hodgkin's Disease	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8836	Refractory_Hodgkin_s_Lymphoma	Hodgkin_s_Lymphoma|Refractory_Hematologic_Malignancy	Refractory Hodgkin's Lymphoma|Refractory Hodgkin Lymphoma|Refractory Hodgkin's Disease|Refractory Hodgkins Disease|Refractory Hodgkins Lymphoma	Hodgkin's disease resistant to treatment
C8837	Recurrent_Nodular_Sclerosis_Hodgkin_s_Lymphoma	Nodular_Sclerosis_Hodgkin_s_Lymphoma|Recurrent_Hodgkin_s_Lymphoma	Recurrent Nodular Sclerosis Hodgkin's Lymphoma|Recurrent Hodgkin's Nodular Sclerosis|Recurrent Nodular Sclerosis Hodgkin Lymphoma|Recurrent Nodular Sclerosis Hodgkin's Disease|Relapsed Nodular Sclerosis Hodgkin's Disease|Relapsed Nodular Sclerosis Hodgkin's Lymphoma
C8838	Refractory_Nodular_Sclerosis_Hodgkin_s_Lymphoma	Nodular_Sclerosis_Hodgkin_s_Lymphoma|Refractory_Hodgkin_s_Lymphoma	Refractory Nodular Sclerosis Hodgkin's Lymphoma|Refractory Nodular Sclerosis Hodgkin Lymphoma|Refractory Nodular Sclerosis Hodgkin's Disease
C8839	Stage_I_Nodular_Sclerosis_Hodgkin_s_Lymphoma	Nodular_Sclerosis_Hodgkin_s_Lymphoma|Stage_I_Hodgkin_s_Lymphoma	Stage I Nodular Sclerosis Hodgkin's Lymphoma|Nodular Sclerosis Hodgkin's Disease Stage I|Nodular Sclerosis Hodgkin's Lymphoma Stage I|Stage I Nodular Sclerosis Hodgkin Lymphoma|Stage I Nodular Sclerosis Hodgkin's Disease	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C8840	Stage_IV_Nodular_Sclerosis_Hodgkin_s_Lymphoma	Nodular_Sclerosis_Hodgkin_s_Lymphoma|Stage_IV_Hodgkin_s_Lymphoma	Stage IV Nodular Sclerosis Hodgkin's Lymphoma|Nodular Sclerosis Hodgkin's Disease Stage IV|Nodular Sclerosis Hodgkin's Lymphoma Stage IV|Stage IV Nodular Sclerosis Hodgkin Lymphoma|Stage IV Nodular Sclerosis Hodgkin's Disease	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8841	Recurrent_B-Cell_Non-Hodgkin_s_Lymphoma	B-Cell_Non-Hodgkin_s_Lymphoma|Recurrent_Non-Hodgkin_s_Lymphoma	Recurrent B-Cell Non-Hodgkin's Lymphoma|B-Cell Lymphoma Recurrent|Recurrent B-Cell Lymphoma|Recurrent B-Cell Non-Hodgkin Lymphoma	The reemergence of B-cell lymphoma after a period of remission
C8842	Refractory_B-Cell_Non-Hodgkin_s_Lymphoma	B-Cell_Non-Hodgkin_s_Lymphoma|Refractory_Non-Hodgkin_s_Lymphoma	Refractory B-Cell Non-Hodgkin's Lymphoma|B-Cell Lymphoma Refractory|Refractory B-Cell Lymphoma|Refractory B-Cell Non-Hodgkin Lymphoma	B-cell non-Hodgkin's lymphoma that is resistant to treatment
C8843	Stage_II_B-Cell_Non-Hodgkin_s_Lymphoma	B-Cell_Non-Hodgkin_s_Lymphoma|Stage_II_Non-Hodgkin_s_Lymphoma	Stage II B-Cell Non-Hodgkin's Lymphoma|B Cell Lymphoma Stage II|B-Cell Lymphoma Stage II|Stage II B Cell Lymphoma|Stage II B-Cell Lymphoma	Stage II NHL means involvement of two or more lymph node regions on the same side of the diaphragm (II) or localized involvement of a single associated extralymphatic organ or site and its regional lymph nodes with or without other lymph node regions on the same side of the diaphragm (IIE). Note: The number of lymph node regions involved may be indicated by a subscript (e.g., II3). (PDQ)
C8844	Stage_III_B-Cell_Non-Hodgkin_s_Lymphoma	B-Cell_Non-Hodgkin_s_Lymphoma|Stage_III_Non-Hodgkin_s_Lymphoma	Stage III B-Cell Non-Hodgkin's Lymphoma|B Cell Lymphoma Stage III|B-Cell Lymphoma Stage III|Stage III B Cell Lymphoma|Stage III B-Cell Lymphoma	Stage III NHL means involvement of lymph node regions on both sides of the diaphragm (III) that may also be accompanied by localized involvement of an extralymphatic organ or site (IIIE), by involvement of the spleen (IIIS), or both (IIIS+E). (PDQ)
C8845	Stage_IV_B-Cell_Non-Hodgkin_s_Lymphoma	B-Cell_Non-Hodgkin_s_Lymphoma|Stage_IV_Non-Hodgkin_s_Lymphoma	Stage IV B-Cell Non-Hodgkin's Lymphoma|B Cell Lymphoma Stage IV|B-Cell Lymphoma Stage IV|Stage IV B Cell Lymphoma|Stage IV B-Cell Lymphoma	Stage IV NHL means disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement. (PDQ)
C8846	Refractory_Small_Lymphocytic_Lymphoma	Refractory_Mature_B-Cell_Non-Hodgkin_s_Lymphoma|Small_Lymphocytic_Lymphoma	Refractory Small Lymphocytic Lymphoma|B-Cell Small Lymphocytic Lymphoma Refractory|Refractory B-Cell Small Lymphocytic Lymphoma	B-cell small lymphocytic lymphoma that is resistant to treatment
C8847	Refractory_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma|Refractory_Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Refractory Burkitt's Lymphoma|Burkitt's Lymphoma Refractory	Burkitt's lymphoma that is resistant to treatment.
C8848	Stage_I_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma|Stage_I_B-Cell_Non-Hodgkin_s_Lymphoma	Stage I Burkitt's Lymphoma|Burkitt's Lymphoma Stage I	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C8849	Stage_II_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma|Stage_II_B-Cell_Non-Hodgkin_s_Lymphoma	Stage II Burkitt's Lymphoma|Burkitt's Lymphoma Stage II	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C8850	Stage_III_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma|Stage_III_B-Cell_Non-Hodgkin_s_Lymphoma	Stage III Burkitt's Lymphoma|Burkitt's Lymphoma Stage III	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C8851	Diffuse_Large_B-Cell_Lymphoma	Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Diffuse Large B-Cell Lymphoma|DLBCL	This non-Hodgkin's lymphoma is characterized by a diffuse proliferation of predominantly large neoplastic B lymphocytes.  It is the most frequently seen type of non-Hodgkin's lymphoma, representing 30%-40% of the cases.  Morphologic variants include centroblastic lymphoma, immunoblastic lymphoma, T-cell/histiocyte rich lymphoma, anaplastic lymphoma, plasmablastic lymphoma, and diffuse large B-cell lymphoma with expression of full-length ALK. (WHO, 2001) -- 2003
C8852	Recurrent_Diffuse_Large_B-Cell_Lymphoma	Diffuse_Large_B-Cell_Lymphoma|Recurrent_B-Cell_Non-Hodgkin_s_Lymphoma	Recurrent Diffuse Large B-Cell Lymphoma|Relapsed Diffuse Large B-Cell Lymphoma	The reemergence of diffuse large B-cell lymphoma after a period of remission.
C8853	Refractory_Diffuse_Large_B-Cell_Lymphoma	Diffuse_Large_B-Cell_Lymphoma|Refractory_Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Refractory Diffuse Large B-Cell Lymphoma|Diffuse Large B-Cell Lymphoma Refractory	Diffuse large B-cell lymphoma that is resistant to treatment.
C8854	Stage_I_Diffuse_Large_B-Cell_Lymphoma	Diffuse_Large_B-Cell_Lymphoma|Stage_I_B-Cell_Non-Hodgkin_s_Lymphoma	Stage I Diffuse Large B-Cell Lymphoma|Diffuse Large B-Cell Lymphoma Stage I	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C8855	Stage_II_Diffuse_Large_B-Cell_Lymphoma	Diffuse_Large_B-Cell_Lymphoma|Stage_II_B-Cell_Non-Hodgkin_s_Lymphoma	Stage II Diffuse Large B-Cell Lymphoma|Diffuse Large B-Cell Lymphoma Stage II	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C8856	Stage_III_Diffuse_Large_B-Cell_Lymphoma	Diffuse_Large_B-Cell_Lymphoma|Stage_III_B-Cell_Non-Hodgkin_s_Lymphoma	Stage III Diffuse Large B-Cell Lymphoma|Diffuse Large B-Cell Lymphoma Stage III	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C8857	Stage_IV_Diffuse_Large_B-Cell_Lymphoma	Diffuse_Large_B-Cell_Lymphoma|Stage_IV_B-Cell_Non-Hodgkin_s_Lymphoma	Stage IV Diffuse Large B-Cell Lymphoma|Diffuse Large B-Cell Lymphoma Stage IV	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8858	Refractory_Follicular_Lymphoma	Follicular_Lymphoma|Refractory_Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Refractory Follicular Lymphoma	Follicle centre lymphoma, follicular grade I, II, III that is resistant to treatment.
C8859	Stage_I_Follicular_Lymphoma	Follicular_Lymphoma|Stage_I_B-Cell_Non-Hodgkin_s_Lymphoma	Stage I Follicular Lymphoma	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C8860	Stage_II_Follicular_Lymphoma	Follicular_Lymphoma|Stage_II_B-Cell_Non-Hodgkin_s_Lymphoma	Stage II Follicular Lymphoma	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C8861	Stage_III_Follicular_Lymphoma	Follicular_Lymphoma|Stage_III_B-Cell_Non-Hodgkin_s_Lymphoma	Stage III Follicular Lymphoma	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C8862	Refractory_Mantle_Cell_Lymphoma	Mantle_Cell_Lymphoma|Refractory_Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Refractory Mantle Cell Lymphoma|Mantle Cell Lymphoma Refractory	Mantle cell lymphoma resistant to treatment
C8863	Nodal_Marginal_Zone_B-Cell_Lymphoma	Marginal_Zone_B-Cell_Lymphoma	Nodal Marginal Zone B-Cell Lymphoma|Monocytoid B-Cell Lymphoma	A primary nodal B-cell non-Hodgkin's lymphoma which morphologically resembles lymph nodes involved by marginal zone lymphomas of extranodal or splenic types, but without evidence of extranodal or splenic disease.  This is a rare entity, and most patients present with localized or generalized lymphadenopathy.  The clinical course is indolent.  (WHO, 2001) -- 2003
C8864	Stage_I_Nodal_Marginal_Zone_B-Cell_Lymphoma	Nodal_Marginal_Zone_B-Cell_Lymphoma|Stage_I_B-Cell_Non-Hodgkin_s_Lymphoma	Stage I Nodal Marginal Zone B-Cell Lymphoma|Nodal Marginal Zone B-Cell Lymphoma Stage I	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).-2003
C8865	Stage_II_Nodal_Marginal_Zone_B-Cell_Lymphoma	Nodal_Marginal_Zone_B-Cell_Lymphoma|Stage_II_B-Cell_Non-Hodgkin_s_Lymphoma	Stage II Nodal Marginal Zone B-Cell Lymphoma|Nodal Marginal Zone B-Cell Lymphoma Stage II	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C8866	Stage_III_Nodal_Marginal_Zone_B-Cell_Lymphoma	Nodal_Marginal_Zone_B-Cell_Lymphoma|Stage_III_B-Cell_Non-Hodgkin_s_Lymphoma	Stage III Nodal Marginal Zone B-Cell Lymphoma|Nodal Marginal Zone B-Cell Lymphoma Stage III	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C8867	Stage_IV_Nodal_Marginal_Zone_B-Cell_Lymphoma	Nodal_Marginal_Zone_B-Cell_Lymphoma|Stage_IV_B-Cell_Non-Hodgkin_s_Lymphoma	Stage IV Nodal Marginal Zone B-Cell Lymphoma|Nodal Marginal Zone B-Cell Lymphoma Stage IV	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8868	Precursor_B_Lymphoblastic_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|B-Cell_Non-Hodgkin_s_Lymphoma|Precursor_B_Lymphoblastic_Leukemia_Lymphoma|Precursor_Lymphoblastic_Lymphoma	Precursor B-Lymphoblastic Lymphoma	An uncommon type of lymphoma and constitutes approximately 10% of cases of lymphoblastic lymphoma.  Approximately 75% of cases reported in a literature review were less than 18 years of age.  (WHO, 2001) -- 2003
C8869	Recurrent_Precursor_B-Lymphoblastic_Lymphoma	Precursor_B_Lymphoblastic_Lymphoma|Recurrent_B-Cell_Non-Hodgkin_s_Lymphoma	Recurrent Precursor B-Lymphoblastic Lymphoma|Relapsed Precursor B-Lymphoblastic Lymphoma
C8870	Refractory_Precursor_B-Lymphoblastic_Lymphoma	Precursor_B_Lymphoblastic_Lymphoma|Refractory_B-Cell_Non-Hodgkin_s_Lymphoma	Refractory Precursor B-Lymphoblastic Lymphoma|Precursor B-Lymphoblastic Lymphoma Refractory	Precursor B-lymphoblastic lymphoma resistant to treatment
C8871	Stage_I_Precursor_B-Lymphoblastic_Lymphoma	Precursor_B_Lymphoblastic_Lymphoma|Stage_I_B-Cell_Non-Hodgkin_s_Lymphoma	Stage I Precursor B-Lymphoblastic Lymphoma|Precursor B-Lymphoblastic Lymphoma Stage I	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C8872	Stage_III_Precursor_B-Lymphoblastic_Lymphoma	Precursor_B_Lymphoblastic_Lymphoma|Stage_III_B-Cell_Non-Hodgkin_s_Lymphoma	Stage III Precursor B-Lymphoblastic Lymphoma|Precursor B-Lymphoblastic Lymphoma Stage III	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C8873	Stage_IV_Precursor_B-Lymphoblastic_Lymphoma	Precursor_B_Lymphoblastic_Lymphoma|Stage_IV_B-Cell_Non-Hodgkin_s_Lymphoma	Stage IV Precursor B-Lymphoblastic Lymphoma|Precursor B-Lymphoblastic Lymphoma Stage IV	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8874	Recurrent_Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma	Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma|Recurrent_Diffuse_Large_B-Cell_Lymphoma	Recurrent Mediastinal (Thymic) Large B-Cell Cell Lymphoma|Recurrent Primary Mediastinal Large B-Cell Lymphoma|Relapsed Primary Mediastinal Large B-Cell Lymphoma
C8875	Refractory_Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma	Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma|Refractory_Mature_B-Cell_Non-Hodgkin_s_Lymphoma	Refractory Mediastinal (Thymic) Large B-Cell Cell Lymphoma|Primary Mediastinal Large B-Cell Lymphoma Refractory|Refractory Primary Mediastinal Large B-Cell Lymphoma	Primary mediastinal large B-cell lymphoma resistant to treatment.
C8876	Stage_I_Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma	Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma|Stage_I_Diffuse_Large_B-Cell_Lymphoma	Stage I Mediastinal (Thymic) Large B-Cell Cell Lymphoma|Primary Mediastinal Large B-Cell Lymphoma Stage I|Stage I Primary Mediastinal Large B-Cell Lymphoma	Ann Arbor Classification: Stage I: Involvement of a single lymph node region (I); or localized involvement of a single extralymphatic organ or site in the absence of any lymph node involvement (IE) (rare in Hodgkin lymphoma).- 2003
C8877	Stage_II_Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma	Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma|Stage_II_Diffuse_Large_B-Cell_Lymphoma	Stage II Mediastinal (Thymic) Large B-Cell Cell Lymphoma|Primary Mediastinal Large B-Cell Lymphoma Stage II|Stage II Primary Mediastinal Large B-Cell Lymphoma	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C8878	Stage_III_Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma	Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma|Stage_III_Diffuse_Large_B-Cell_Lymphoma	Stage III Mediastinal (Thymic) Large B-Cell Cell Lymphoma|Primary Mediastinal Large B-Cell Lymphoma Stage III|Stage III Primary Mediastinal Large B-Cell Lymphoma	Ann Arbor Classification: Stage III: Involvement of lymph node regions on both sides of the diaphragm (III), which also may be accompanied by extralymphatic extension in association with adjacent lymph node involvement (IIIE) or by involvement of the spleen (IIIS) or both (IIIE,S). - 2003
C8879	Stage_IV_Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma	Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma|Stage_IV_Diffuse_Large_B-Cell_Lymphoma	Stage IV Mediastinal (Thymic) Large B-Cell Cell Lymphoma|Primary Mediastinal Large B-Cell Lymphoma Stage IV|Stage IV Primary Mediastinal Large B-Cell Lymphoma	Ann Arbor Classification: Stage IV: Diffuse or disseminated involvement of one or more extralymphatic organs, with or without associated lymph node involvement; or isolated extralymphatic organ involvement in the absence of adjacent regional lymph node involvement, but in conjunction with disease in distant site(s); or any involvement of the liver or bone marrow or nodular involvement of the lung(s). - 2003
C8880	Extragonadal_Embryonal_Carcinoma	Embryonal_Carcinoma|Malignant_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor	Extragonadal Embryonal Carcinoma|Extragonadal Primary Embryonal Carcinoma|Primary Extragonadal Embryonal Carcinoma
C8881	Malignant_Extragonadal_Germ_Cell_Tumor	Extragonadal_Germ_Cell_Neoplasm|Malignant_Germ_Cell_Neoplasm	Malignant Extragonadal Germ Cell Tumor|Malignant Neoplasm of Extragonadal Germ Cell|Malignant Neoplasm of the Extragonadal Germ Cell|Malignant Tumor of Extragonadal Germ Cell|Malignant Tumor of the Extragonadal Germ Cell
C8882	Stage_I_Extragonadal_Primary_Mixed_Germ_Cell_Tumor	Extragonadal_Germ_Cell_Neoplasm	Stage I Extragonadal Primary Mixed Germ Cell Tumor|Stage I Extragonadal Primary Germ Cell Tumor Mixed
C8883	Stage_III_Extragonadal_Primary_Mixed_Germ_Cell_Tumor	Extragonadal_Germ_Cell_Neoplasm	Stage III Extragonadal Primary Mixed Germ Cell Tumor|Stage III Extragonadal Primary Germ Cell Tumor Mixed
C8884	Immature_Extragonadal_Teratoma	Immature_Teratoma|Malignant_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor	Immature Extragonadal Teratoma|Extragonadal Primary Malignant Teratoma|Malignant Extragonadal Teratoma|Primary Malignant Extragonadal Teratoma
C8885	Malignant_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor	Malignant_Extragonadal_Germ_Cell_Tumor	Malignant Extragonadal Non-Seminomatous Germ Cell Tumor|Cancer of Extragonadal Non-Seminomatous Germ Cell|Cancer of the Extragonadal Non-Seminomatous Germ Cell|Extragonadal Non-Seminomatous Germ Cell Cancer|Extragonadal Primary Nonseminoma|Malignant Extragonadal Non-Seminomatous Germ Cell Neoplasm|Malignant Extragonadal Nonseminoma|Malignant Neoplasm of Extragonadal Non-Seminomatous Germ Cell|Malignant Neoplasm of the Extragonadal Non-Seminomatous Germ Cell|Malignant Tumor of Extragonadal Non-Seminomatous Germ Cell|Malignant Tumor of the Extragonadal Non-Seminomatous Germ Cell|Primary Malignant Extragonadal Nonseminoma
C8886	Stage_I_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor	Malignant_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor	Stage I Extragonadal Non-Seminomatous Germ Cell Tumor
C8887	Stage_II_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor	Malignant_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor	Stage II Extragonadal Non-Seminomatous Germ Cell Tumor
C8888	Stage_III_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor	Malignant_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor	Stage III Extragonadal Non-Seminomatous Germ Cell Tumor
C8889	Stage_IV_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor	Malignant_Extragonadal_Non-Seminomatous_Germ_Cell_Tumor	Stage IV Extragonadal Non-Seminomatous Germ Cell Tumor
C8890	Stage_II_Extragonadal_Primary_Seminoma	Extragonadal_Primary_Seminoma|Stage_II_Seminoma	Stage II Extragonadal Primary Seminoma
C8891	Stage_III_Extragonadal_Primary_Seminoma	Extragonadal_Primary_Seminoma|Stage_III_Seminoma	Stage III Extragonadal Primary Seminoma
C8892	Stage_IV_Extragonadal_Primary_Seminoma	Extragonadal_Primary_Seminoma	Stage IV Extragonadal Primary Seminoma
C8893	Placental_Choriocarcinoma	Gestational_Choriocarcinoma|Malignant_Endocrine_Neoplasm|Malignant_Placental_Neoplasm|Reproductive_Endocrine_Neoplasm	Placental Choriocarcinoma|Choriocarcinoma of Placenta|Choriocarcinoma of the Placenta|Placenta Choriocarcinoma
C8894	Stage_0_Bladder_Adenocarcinoma	Bladder_Adenocarcinoma|Stage_0_Bladder_Cancer	Stage 0 Bladder Adenocarcinoma	Stage 0 includes Ta,Tis,N0,M0.  Ta: Noninvasive papillary carcinoma.  Tis: Carcinoma in situ: "flat tumor".  N0: No regional lymph node metastasis.  M0: No distant metastasis (PDQ)
C8895	Stage_I_Bladder_Adenocarcinoma	Bladder_Adenocarcinoma|Stage_I_Bladder_Cancer	Stage I Bladder Adenocarcinoma|Bladder Adenocarcinoma Stage I	TNM stage: T1, N0, M0 (T1 is tumor that invades subepithelial connective tissue, N 0 means no lymph node metastases, M 0 means no distant metastases) from PDQ
C8896	Stage_II_Bladder_Adenocarcinoma	Bladder_Adenocarcinoma|Stage_II_Bladder_Cancer	Stage II Bladder Adenocarcinoma	TNM stage: T2 a or b, N0, M0 (T2a is tumor that invades superficial muscle, T2b invades deep muscle, N 0 means no lymph node metastases, M 0 means no distant metastases) from PDQ
C8897	Stage_III_Bladder_Adenocarcinoma	Bladder_Adenocarcinoma|Stage_III_Bladder_Cancer	Stage III Bladder Adenocarcinoma	TNM stage: T3 a or b, T4a,, N0, M0 (T3 is tumor that invades paravesical tissue,T3a is microscopic invasion, T3b is macroscopic invasion, T4a is invasion of the prostate uterus or vagina, N 0 means no lymph node metastases, M 0 means no distant metastases) from PDQ
C8898	Stage_IV_Bladder_Adenocarcinoma	Bladder_Adenocarcinoma|Stage_IV_Bladder_Cancer	Stage IV Bladder Adenocarcinoma	Stage 4 includes T4b,N0,M0/anyT,N1-3,M0/anyT,anyN,M1.  T4b: Tumor invades the pelvic wall, abdominal wall.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension.  M1: Distant metastasis (PDQ)
C8899	Stage_I_Bladder_Cancer_with_Carcinoma_in_situ	Stage_I_Bladder_Cancer	Stage I Bladder Cancer with Carcinoma In Situ|Stage I Bladder Cancer with Cancer in situ|Stage I Bladder Carcinoma with Carcinoma in situ
C8900	Stage_III_Testicular_Choriocarcinoma	Stage_III_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Testicular_Choriocarcinoma	Stage III Testicular Choriocarcinoma	Stage 3 includes anypT,anyN,M1,SX.  N1:Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension.  M1: Distant metastasis (PDQ)
C8901	Stage_I_Bladder_Cancer_without_Carcinoma_in_situ	Stage_I_Bladder_Cancer	Stage I Bladder Cancer without Carcinoma In Situ|Stage I Bladder Cancer without Cancer in situ|Stage I Bladder Carcinoma without Carcinoma in situ	Stage I includes T1, NO, MO. T1: Tumor invades subepithelial connective tissue.
C8902	Recurrent_Bladder_Squamous_Cell_Carcinoma	Bladder_Squamous_Cell_Carcinoma|Recurrent_Bladder_Cancer	Recurrent Bladder Squamous Cell Carcinoma|Recurrent Bladder Epidermoid Carcinoma|Recurrent Epidermoid Carcinoma of Bladder|Recurrent Epidermoid Carcinoma of Urinary Bladder|Recurrent Epidermoid Carcinoma of the Bladder|Recurrent Epidermoid Carcinoma of the Urinary Bladder|Recurrent Squamous Cell Carcinoma of Bladder|Recurrent Squamous Cell Carcinoma of Urinary Bladder|Recurrent Squamous Cell Carcinoma of the Bladder|Recurrent Squamous Cell Carcinoma of the Urinary Bladder|Recurrent Urinary Bladder Epidermoid Carcinoma|Recurrent Urinary Bladder Squamous Cell Carcinoma|Relapsed Bladder Epidermoid Carcinoma|Relapsed Bladder Squamous Cell Carcinoma|Relapsed Epidermoid Carcinoma of Bladder|Relapsed Epidermoid Carcinoma of Urinary Bladder|Relapsed Epidermoid Carcinoma of the Bladder|Relapsed Epidermoid Carcinoma of the Urinary Bladder|Relapsed Squamous Cell Carcinoma of Bladder|Relapsed Squamous Cell Carcinoma of Urinary Bladder|Relapsed Squamous Cell Carcinoma of the Bladder|Relapsed Squamous Cell Carcinoma of the Urinary Bladder|Relapsed Urinary Bladder Epidermoid Carcinoma|Relapsed Urinary Bladder Squamous Cell Carcinoma|Squamous Cell Carcinoma of Bladder, Recurrent|Squamous Cell Carcinoma of the Bladder, Recurrent	The reemergence of bladder squamous cell carcinoma after a period of remission
C8903	Stage_0_Bladder_Squamous_Cell_Carcinoma	Bladder_Squamous_Cell_Carcinoma|Stage_0_Bladder_Cancer	Stage 0 Bladder Squamous Cell Carcinoma|Stage 0 Squamous Cell Carcinoma of Bladder|Stage 0 Squamous Cell Carcinoma of the Bladder	Staging is by TNM classification. Stage O would include Ta NO MO.  Ta: Noninvasive papillary carcinoma.  N0: No regional lymph node metastasis.  M0: No distant metastasis
C8904	Stage_I_Squamous_Cell_Carcinoma_of_the_Bladder	Bladder_Squamous_Cell_Carcinoma|Stage_I_Bladder_Cancer	Stage I Squamous Cell Carcinoma of the Bladder|Bladder Squamous Cell Carcinoma Stage I|Stage I Squamous Cell Carcinoma of Bladder	TNM staging: T1 N0 M0- T1 means tumor invades subepithelial connective tissue, N0 means no regional lymph node mets, M0 means no distant mets.
C8905	Stage_III_Bladder_Squamous_Cell_Carcinoma	Bladder_Squamous_Cell_Carcinoma|Stage_III_Bladder_Cancer	Stage III Bladder Squamous Cell Carcinoma	TNM staging: T3a/b or T4 and N0 M0-T3a means tumor invades perivesicular tissue microscopically,,T3b means tumor invades macroscopically, T4 indicates invasion of prostate, uterus or vagina, N0 means no regional lymph node metastases, M0 means no distant metastases.
C8906	Stage_IV_Bladder_Squamous_Cell_Carcinoma	Bladder_Squamous_Cell_Carcinoma|Stage_IV_Bladder_Cancer	Stage IV Bladder Squamous Cell Carcinoma	Stage IV would include T4b NO MO/any T N1 MO/ any T N2 MO/ any T N3 MO/ any T any N M1. T4b: Tumor invades the pelvic wall, abdominal wall.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension. N3: Metastasis in a lymph node more than 5 cm in greatest dimension.  M1: Distant metastasis
C8907	Stage_I_Testicular_Choriocarcinoma	Stage_I_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Testicular_Choriocarcinoma	Stage I Testicular Choriocarcinoma	Stage 1 includes pT1-T4,N0,M0,SX.  pT1: Tumor limited to testis and epididymis without lymphatic/vascular invasion.  pT2: Tumor limited to testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis.  pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion.  pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  SX: Marker studies not available or not performed.
C8908	Stage_I_Testicular_Embryonal_Carcinoma	Stage_I_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Testicular_Embryonal_Carcinoma	Stage I Testicular Embryonal Carcinoma	Stage I includes: pT1-4, N0, M0,SX.  pT1: Tumor limited to testis and epididymis without lymphatic/vascular invasion.  pT2: Tumor limited to testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis.  pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion.  pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  SX: Marker studies not available or not performed.  - 2003
C8909	Stage_II_Testicular_Embryonal_Carcinoma	Stage_II_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Testicular_Embryonal_Carcinoma	Stage II Testicular Embryonal Carcinoma	Stage II includes: Any pT, N1-3, M0, SX. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension. N3: Metastasis in a lymph node more than 5 cm in greatest dimension. M0: No distant metastasis. (AJCC 6th ed.) - 2003
C8910	Stage_III_Testicular_Embryonal_Carcinoma	Stage_III_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Testicular_Embryonal_Carcinoma	Stage III Testicular Embryonal Carcinoma	Stage III includes: Any pT, Any N, M1, SX.  M1:distant metastasis. (AJCC 6th ed.) - 2003
C8911	Stage_II_Testicular_Mixed_Germ_Cell_Tumor	Stage_II_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Testicular_Mixed_Germ_Cell_Neoplasm	Stage II Testicular Mixed Germ Cell Tumor	Stage 2 includes anypT,N1-3,M0,SX.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension.
C8912	Stage_I_Testicular_Mixed_Germ_Cell_Tumor	Stage_I_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Testicular_Mixed_Germ_Cell_Neoplasm	Stage I Testicular Mixed Germ Cell Tumor	Stage 1 includes pT1-T4,N0,M0,SX.  pT1: Tumor limited to testis and epididymis without lymphatic/vascular invasion.  pT2: Tumor limited to testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis.  pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion.  pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  SX: Marker studies not available or not performed.
C8913	Stage_III_Testicular_Mixed_Germ_Cell_Tumor	Stage_III_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Testicular_Mixed_Germ_Cell_Neoplasm	Stage III Testicular Mixed Germ Cell Tumor	Stage 3 includes anypT,anyN,M1,SX.  M1:Distant metastasis.
C8914	Stage_I_Immature_Testicular_Teratoma	Immature_Testicular_Teratoma|Stage_I_Testicular_Non-Seminomatous_Germ_Cell_Tumor	Stage I Immature Testicular Teratoma	Stage 1 includes pT1-T4,N0,M0,SX.  pT1: Tumor limited to testis and epididymis without lymphatic/vascular invasion.  pT2: Tumor limited to testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis.  pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion.  pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  SX: Marker studies not available or not performed.
C8915	Stage_II_Immature_Testicular_Teratoma	Immature_Testicular_Teratoma|Stage_II_Testicular_Non-Seminomatous_Germ_Cell_Tumor	Stage II Immature Testicular Teratoma	Stage 2 includes any T, N1-3,M0,SX.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension.
C8916	Stage_III_Immature_Testicular_Teratoma	Immature_Testicular_Teratoma|Stage_III_Testicular_Non-Seminomatous_Germ_Cell_Tumor	Stage III Immature Testicular Teratoma	Stage 3 includes anypT,anyN,M1,SX.  M1: Distant metastasis.
C8917	Stage_I_Testicular_Seminoma	Stage_I_Seminoma|Stage_I_Testicular_Cancer|Testicular_Seminoma	Stage I Testicular Seminoma|Stage I Seminoma of Testis|Stage I Seminoma of the Testis	Stage 1 includes pT1-4, N0,M0,SX.  pT1: Tumor limited to testis and epididymis without lymphatic/vascular invasion.  pT2: Tumor limited to testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis.  pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion.  pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  SX: Marker studies not available or not performed.
C8918	Stage_II_Testicular_Seminoma	Stage_II_Seminoma|Stage_II_Testicular_Cancer|Testicular_Seminoma	Stage II Testicular Seminoma|Stage II Seminoma of Testis|Stage II Seminoma of the Testis	Stage 2 includes anypT,N1-3,M0,SX. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension.
C8919	Stage_III_Testicular_Seminoma	Stage_III_Seminoma|Stage_III_Testicular_Cancer|Testicular_Seminoma	Stage III Testicular Seminoma	Stage 3 includes anypT, anyN, M1,SX.  M1:distant metastasis.
C8920	Stage_I_Testicular_Yolk_Sac_Tumor	Stage_I_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Testicular_Yolk_Sac_Tumor	Stage I Testicular Yolk Sac Tumor	Stage 1 includes pT1-4, N0,M0,SX.  pT1: Tumor limited to testis and epididymis without lymphatic/vascular invasion.  pT2: Tumor limited to testis and epididymis with vascular/lymphatic invasion, or tumor extending through the tunica albuginea with involvement of the tunica vaginalis.  pT3: Tumor invades the spermatic cord with or without vascular/lymphatic invasion.  pT4: Tumor invades the scrotum with or without vascular/lymphatic invasion.  N0: No regional lymph node metastasis.  M0: No distant metastasis.  SX: Marker studies not available or not performed.
C8921	Stage_II_Testicular_Yolk_Sac_Tumor	Stage_II_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Testicular_Yolk_Sac_Tumor	Stage II Testicular Yolk Sac Tumor	Stage 2 includes anyT, N1-3, M0,SX.  N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension.  N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension.  N3: Metastasis in a lymph node more than 5 cm in greatest dimension.
C8922	Stage_III_Testicular_Yolk_Sac_Tumor	Stage_III_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Testicular_Yolk_Sac_Tumor	Stage III Testicular Yolk Sac Tumor	Stage 3 includes anypT,anyN,M1,SX. M1:distant metastasis.
C8923	Acute_Erythroid_Leukemia	Acute_Myeloid_Leukemia_not_Otherwise_Categorized|Erythroid_Neoplasm	Acute Erythroid Leukemia|Acute Erythroblastic Leukemia|Di Guglielmo Disease|Di Guglielmo's Disease|DiGuglielmo Syndrome|DiGuglielmo's Disease|Erythroblastic Leukemia|FAB M6|M6 Acute Myeloid Leukemia	(eh-RITH-ro-loo-KEE-mee-a) Cancer of the blood-forming tissues in which large numbers of immature, abnormal red blood cells are found in the blood and bone marrow.
C8924	Erythema_Multiforme_Minor	Erythema_Multiforme	Erythema Multiforme Minor	Self-limiting form of Erythema Multiforme.
C8925	Metastatic_Melanoma	Melanoma	Metastatic Melanoma	A melanoma that has spread from its primary site to another anatomic site.  Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain. -- 2004
C8926	Recurrent_Centroblastic_Lymphoma	Centroblastic_Lymphoma|Recurrent_Diffuse_Large_B-Cell_Lymphoma	Recurrent Centroblastic Lymphoma
C8927	Refractory_Centroblastic_Lymphoma	Centroblastic_Lymphoma|Refractory_Diffuse_Large_B-Cell_Lymphoma	Refractory Centroblastic Lymphoma
C8928	Stage_I_Centroblastic_Lymphoma	Centroblastic_Lymphoma|Stage_I_Diffuse_Large_B-Cell_Lymphoma	Stage I Centroblastic Lymphoma
C8929	Stage_II_Centroblastic_Lymphoma	Centroblastic_Lymphoma|Stage_II_Diffuse_Large_B-Cell_Lymphoma	Stage II Centroblastic Lymphoma
C8930	Stage_III_Centroblastic_Lymphoma	Centroblastic_Lymphoma|Stage_III_Diffuse_Large_B-Cell_Lymphoma	Stage III Centroblastic Lymphoma
C8931	Stage_IV_Centroblastic_Lymphoma	Centroblastic_Lymphoma|Stage_IV_Diffuse_Large_B-Cell_Lymphoma	Stage IV Centroblastic Lymphoma
C8932	Stage_0_Colorectal_Cancer	Colorectal_Carcinoma|Gastrointestinal_Carcinoma_in_situ	Stage 0 Colorectal Cancer|Colorectal Cancer, Stage 0|Colorectal Carcinoma Stage 0|Colorectal Carcinoma in situ|Stage 0 Colorectal Carcinoma	Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ: intraepithelial or invasion of the lamina propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003
C8933	Metastatic_Pancreatic_Adenocarcinoma	Metastatic_Adenocarcinoma|Pancreatic_Adenocarcinoma	Metastatic Pancreatic Adenocarcinoma
C8934	Metastatic_Small_Intestinal_Adenocarcinoma	Metastatic_Adenocarcinoma|Metastatic_Small_Intestinal_Carcinoma|Small_Intestinal_Adenocarcinoma	Metastatic Small Intestinal Adenocarcinoma
C8935	Papillary_Bile_Duct_Adenocarcinoma	Extrahepatic_Bile_Duct_Adenocarcinoma|Papillary_Adenocarcinoma	Bile Duct Papillary Adenocarcinoma|Papillary Extrahepatic Bile Duct Adenocarcinoma
C8936	Precursor_B_Lymphoblastic_Leukemia_Lymphoma	B-Cell_Lymphocytic_Neoplasm|Precursor_Lymphoblastic_Leukemia_Lymphoma	Precursor B-Lymphoblastic Lymphoma/Leukemia|Precursor B Lymphoblastic Leukemia/Lymphoma	A neoplasm of lymphoblasts committed to the B-cell lineage, typically composed of small to medium-sized blast cells.  When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called precursor B lymphoblastic leukemia (B-cell acute lymphoblastic leukemia).  When it involves nodal or extranodal sites, it is called B lymphoblastic lymphoma. (WHO, 2001) -- 2003
C8937	Stage_II_Precursor_B-Lymphoblastic_Lymphoma	Precursor_B_Lymphoblastic_Lymphoma|Stage_II_B-Cell_Non-Hodgkin_s_Lymphoma	Stage II Precursor B-Lymphoblastic Lymphoma|Precursor B-Lymphoblastic Lymphoma Stage II	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C8938	Refractory_Cutaneous_T-Cell_Lymphoma	Cutaneous_T-Cell_Lymphoma|Refractory_Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Refractory Cutaneous T-Cell Non-Hodgkin's Lymphoma
C8939	Stage_II_Bladder_Transitional_Cell_Carcinoma	Invasive_Urothelial_Transitional_Cell_Carcinoma|Stage_II_Bladder_Cancer	Stage II Bladder Urothelial Carcinoma|Stage II Transitional Cell Carcinoma of Bladder|Stage II Transitional Cell Carcinoma of Urinary Bladder|Stage II Transitional Cell Carcinoma of the Bladder|Stage II Transitional Cell Carcinoma of the Urinary Bladder|Stage II Urinary Bladder Transitional Cell Carcinoma
C8940	Stage_III_Bladder_Transitional_Cell_Carcinoma	Invasive_Urothelial_Transitional_Cell_Carcinoma|Stage_III_Bladder_Cancer	Stage III Bladder Urothelial Carcinoma|Stage III Transitional Cell Carcinoma of Bladder|Stage III Transitional Cell Carcinoma of Urinary Bladder|Stage III Transitional Cell Carcinoma of the Bladder|Stage III Transitional Cell Carcinoma of the Urinary Bladder|Stage III Urinary Bladder Transitional Cell Carcinoma
C8941	Stage_IV_Bladder_Transitional_Cell_Carcinoma	Invasive_Urothelial_Transitional_Cell_Carcinoma|Stage_IV_Bladder_Cancer	Stage IV Bladder Urothelial Carcinoma|Stage IV Transitional Cell Carcinoma of Bladder|Stage IV Transitional Cell Carcinoma of Urinary Bladder|Stage IV Transitional Cell Carcinoma of the Bladder|Stage IV Transitional Cell Carcinoma of the Urinary Bladder|Stage IV Urinary Bladder Transitional Cell Carcinoma
C8942	Metastatic_Endometrial_Adenocarcinoma	Endometrial_Adenocarcinoma|Metastatic_Adenocarcinoma	Metastatic Endometrial Adenocarcinoma
C8943	Metastatic_Endometrioid_Adenocarcinoma	Endometrioid_Carcinoma|Metastatic_Adenocarcinoma	Metastatic Endometrioid Adenocarcinoma|Metastatic Endometrioid Carcinoma
C8944	Vaginal_Metastatic_Adenocarcinoma	Metastatic_Adenocarcinoma|Vaginal_Adenocarcinoma	Vaginal Metastatic Adenocarcinoma
C8945	Metastatic_Prostatic_Adenocarcinoma	Metastatic_Adenocarcinoma|Metastatic_Prostate_Cancer|Prostate_Adenocarcinoma	Metastatic Prostatic Adenocarcinoma
C8946	Metastatic_Prostate_Cancer	Stage_D_Prostate_Cancer|Stage_IV_Prostate_Cancer	Metastatic Prostate Cancer|Metastatic Prostate Carcinoma|Prostate Cancer Metastatic|Prostate Carcinoma Metastatic	Prostate tumor cells spreading and reestablishing themselves in another organ.
C8947	Stage_I_Prostate_Adenocarcinoma	Stage_A_Prostate_Cancer|Stage_I_Prostate_Cancer	Stage I Prostate Adenocarcinoma
C8948	Stage_II_Prostate_Adenocarcinoma	Stage_II_Prostate_Cancer	Stage II Prostate Adenocarcinoma
C8949	Stage_III_Prostate_Adenocarcinoma	Stage_III_Prostate_Cancer	Stage III Prostate Adenocarcinoma
C8950	Stage_IV_Prostate_Adenocarcinoma	Stage_D_Prostate_Cancer|Stage_IV_Prostate_Cancer	Stage IV Prostate Adenocarcinoma
C8951	Stage_IIIA_Adenosquamous_Lung_Carcinoma	Stage_IIIA_Non-Small_Cell_Lung_Cancer|Stage_III_Adenosquamous_Lung_Carcinoma	Stage IIIA Adenosquamous Lung Carcinoma|Stage IIIA Adenosquamous Cell Carcinoma of Lung|Stage IIIA Adenosquamous Cell Carcinoma of the Lung|Stage IIIA Adenosquamous Cell Lung Carcinoma
C8952	Stage_IIIB_Adenosquamous_Lung_Carcinoma	Stage_IIIB_Non-Small_Cell_Lung_Cancer|Stage_III_Adenosquamous_Lung_Carcinoma	Stage IIIB Adenosquamous Lung Carcinoma|Stage IIIB Adenosquamous Cell Carcinoma of Lung|Stage IIIB Adenosquamous Cell Carcinoma of the Lung|Stage IIIB Adenosquamous Cell Lung Carcinoma
C8953	Recurrent_Lung_Cancer	Lung_Carcinoma|Recurrent_Carcinoma	Recurrent Lung Cancer|Recurrent Lung Carcinoma|Recurrent Unspecified Carcinoma of Lung|Recurrent Unspecified Carcinoma of the Lung|Recurrent Unspecified Lung Carcinoma|Relapsed Unspecified Carcinoma of Lung|Relapsed Unspecified Carcinoma of the Lung|Relapsed Unspecified Lung Carcinoma	The re-emergence of lung cancer after a period of remission. (NCI05)
C8954	Stage_II_Lung_Cancer	Lung_Carcinoma	Stage II Lung Cancer|Stage II Carcinoma of Lung|Stage II Carcinoma of the Lung|Stage II Lung Carcinoma
C8955	Rete_Testis_Adenocarcinoma	Adenocarcinoma|Malignant_Male_Reproductive_System_Neoplasm|Rete_Testis_Neoplasm	Rete Testis Adenocarcinoma|Adenocarcinoma of Rete Testis|Adenocarcinoma of the Rete Testis
C8956	Stage_IV_Gastric_Cancer_without_Metastasis	Stage_IV_Gastric_Cancer	Stage IV Gastric Cancer without Metastasis|Carcinoma of Stomach Stage IV without Metastasis|Carcinoma of the Stomach Stage IV without Metastasis|Gastric Carcinoma Stage IV without Metastasis|Gastric Carcinoma, Stage IV Without Metastases|Stomach Carcinoma Stage IV without Metastasis	T4,N2,MO (from PDQ)
C8957	Cutaneous_Precancerous_Condition	Precancerous_Condition_by_Site|Skin_Disorder	Cutaneous Precancerous Condition|Cutaneous Premalignant Condition|Precancerous Dermatosis|Precancerous Skin Lesion|precancerous dermatosis	A skin disease marked by scaly or thickened patches on the skin, and often caused by prolonged exposure to arsenic.  The patches often occur on sunexposed areas of the skin and in older white men.  These patches may become malignant (cancerous).
C8959	Stage_IV_Penile_Cancer	Penile_Carcinoma	Stage IV Penile Cancer|Penile Cancer Stage IV|Stage IV Carcinoma of Penis|Stage IV Carcinoma of the Penis|Stage IV Penile Carcinoma|Stage IV Penis Cancer|Stage IV Penis Carcinoma	Stage IV includes: (T4, Any N, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades other adjacent structures.  N3: Metastasis in deep inguinal or pelvic lymph node(s) unilateral or bilateral.  M1: Distant metastasis.  (AJCC 6th ed.) - 2003
C8960	Familial_Renal_Oncocytoma	Renal_Oncocytoma	Hereditary Renal Oncocytoma|Familial Renal Oncocytoma
C8961	Fundic_Gland_Polyp	Benign_Gastric_Neoplasm|Gastric_Polyp	Fundic Gland Polyp	The most common gastric polyp in the Western hemisphere.  The lesion consists of a localized hyperplasia of the deep epithelial compartment of the oxyntic mucosa, with variable degrees of cystic dilatation.  Malignant transformation is the exception.  (WHO, 2000) -- 2003
C8962	Gastrointestinal_Intraepithelial_Neoplasia	Gastrointestinal_Neoplasm|Gastrointestinal_Precancerous_Condition|Intraepithelial_Neoplasia	Gastrointestinal Intraepithelial Neoplasia|Gastrointestinal Dysplasia
C8963	Stage_IV_Fallopian_Tube_Cancer	Fallopian_Tube_Carcinoma	Stage IV Fallopian Tube Cancer|AJCC Stage IV Fallopian Tube Cancer|FIGO Stage IV Carcinoma of Fallopian Tube|FIGO Stage IV Carcinoma of the Fallopian Tube|FIGO Stage IV Fallopian Tube Carcinoma|Fallopian Tube Cancer Stage IV|Metastatic Fallopian Tube Cancer|Metastatic Fallopian Tube Carcinoma	Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis (excludes metastasis within the peritoneal cavity. (AJCC 6th ed.) - 2003
C8964	Synovial_Neoplasm	Soft_Tissue_Neoplasm	Synovial Neoplasm|Neoplasm of Synovium|Neoplasm of the Synovium|Synovial Tumor|Tumor of Synovium|Tumor of the Synovium
C8965	Lymphangioma	Benign_Lymphatic_Vessel_Neoplasm	Lymphangioma
C8966	Paraneoplastic_Opsoclonus_Ataxia	Paraneoplastic_Syndrome	Paraneoplastic Opsoclonus Ataxia|POA|Paraneoplastic Opsoclonus-Ataxia	Ataxia associated with chaotic multidirectional conjugate eye movements secondary to metastatic tumors to cerebellum.  The most common malignant tumor associated with this paraneoplastic syndrome is lung carcinoma. (NCI)
C8967	Brain_Iron_Accumulation_Type_I_Syndrome	Neurodegenerative_Disorder	Brain Iron Accumulation Type I Syndrome|Hallervorden-Spatz Syndrome|NBIA 1	A rare neuroaxonal dystrophy, histologically characterized by axonal spheroids, iron deposition, lewy body (LB)-like intraneuronal inclusions and neurofibrillary tangles.
C8968	Grade_2_Follicular_Lymphoma	Follicular_Lymphoma|Indolent_Non-Hodgkin_s_Lymphoma	Grade 2 Follicular Lymphoma|Follicular Mixed Cell Lymphoma|Follicular Mixed Lymphocytic-Histiocytic Lymphoma|Grade II Follicular Lymphoma|Grade II Follicular Mixed Cell Lymphoma|Nodular Mixed Lymphoma
C8969	Parosteal_Osteosarcoma	Bone_Surface_Peripheral_Osteosarcoma	Parosteal Osteosarcoma|Juxtacortical Osteogenic Sarcoma|Juxtacortical Osteosarcoma|Parosteal Osteogenic Sarcoma
C8970	Periosteal_Osteosarcoma	Bone_Surface_Peripheral_Osteosarcoma	Periosteal Osteosarcoma|Periosteal Osteogenic Sarcoma
C8971	Embryonal_Rhabdomyosarcoma	Rhabdomyosarcoma|Sarcoma_Differentiation_Score_3	Embryonal Rhabdomyosarcoma|embryonal rhabdomyosarcoma	(EM-bree-on-al RAB-do-MY-oh-sar-KO-ma) A soft-tissue tumor that affects children. It begins in muscle cells, and usually occurs in the head, neck, arms, legs, or genitourinary tract.
C8972	Undifferentiated_Uterine_Sarcoma	Uterine_Corpus_Endometrial_Stromal_Sarcoma	Undifferentiated Endometrial Sarcoma|High Grade Endometrial Stromal Sarcoma|Undifferentiated Endometrial Stromal Sarcoma|Undifferentiated Uterine Sarcoma	An endometrial stromal sarcoma.  This is a high grade sarcoma --2003
C8973	Endometrial_Stromal_Sarcoma	Endometrial_Stromal_Neoplasm|Stromal_Sarcoma	Endometrial Stromal Sarcoma|ESS	A uterine stromal sarcoma originating from the endometrium.  It is further subdivided into low grade endometrial stromal sarcoma and undifferentiated uterine sarcoma. --2003
C8975	Malignant_Mixed_Mesodermal_Mullerian_Tumor	Carcinosarcoma|Mixed_Mesodermal_Mullerian_Tumor	Malignant Mixed Mesodermal (Mullerian) Tumor|MMMT|Malignant Mixed Mesodermal Tumor|Malignant Mixed Mullerian Tumor	An aggressive malignant tumor of the female reproductive system, affecting predominantly elderly menopausal women.  The endometrium and ovary are the most common sites of tumor origin.  Morphologically, it is a high grade tumor, composed of carcinomatous and sarcomatous elements.
C8978	Mucinous_Adenofibroma	Adenofibroma	Mucinous Adenofibroma
C8979	Mucinous_Cystadenofibroma	Cystadenofibroma|Mucinous_Adenofibroma	Mucinous Cystadenofibroma
C8984	Adenofibroma	Mixed_Mesodermal_Mullerian_Tumor	Adenofibroma
C8985	Cystadenofibroma	Adenofibroma	Cystadenofibroma
C8986	Papillary_Adenofibroma	Adenofibroma	Papillary Adenofibroma
C8987	Clear_Cell_Adenofibroma	Adenofibroma	Clear Cell Adenofibroma	A benign neoplasm composed of glandular and fibrous tissues and the presence of clear cells.
C8988	Clear_Cell_Cystadenofibroma	Clear_Cell_Adenofibroma|Cystadenofibroma	Clear Cell Cystadenofibroma	A benign neoplasm characterized by the presence of cystic glandular and fibrous tissues and clear cells.
C8989	Oral_Neoplasm	Head_and_Neck_Neoplasm|Oral_Disorder	Oral Neoplasm|Lip and Oral Cavity Neoplasm|Lip and Oral Cavity Tumor|Lip and Oral Cavity Tumour|Oral Tumor	A benign or malignant tumor involving the oral cavity and/or the lips. -- 2003
C8990	Oral_Cavity_Carcinoma	Lip_and_Oral_Cavity_Carcinoma|Malignant_Oral_Cavity_Neoplasm	Oral Cavity Carcinoma|Carcinoma of Mouth|Carcinoma of Oral Cavity|Carcinoma of the Oral Cavity|Mouth Carcinoma
C8991	Malignant_Mastocytosis	Systemic_Mastocytosis	Malignant Mastocytosis	Malignant neoplasm originating from mast cells. - 2003
C8993	Ureter_Carcinoma	Carcinoma|Malignant_Ureter_Neoplasm	Ureter Carcinoma|Carcinoma of Ureter|Carcinoma of the Ureter|Ureteral Carcinoma	A carcinoma of the ureter.  The majority of ureter carcinomas are transitional cell and less frequently squamous cell carcinomas or adenocarcinomas.  --2003
C8994	Malignant_Lymphoma_Centroblastic_Follicular	Lymphoma_Leukemia_by_Kiel_Classification_Antiquated	Malignant Lymphoma Centroblastic, Follicular
C8995	Malignant_Lymphoma_Follicular_Large_Noncleaved_Cell_Type	Malignant_Lymphoma_Non-Cleaved_Cell_Type	Malignant Lymphoma Follicular, Large Noncleaved Cell Type
C8996	Malignant_Lymphoma_Follicular_Large_Cleaved_Cell_Type	Malignant_Lymphoma_Large_Cell_Cleaved	Malignant Lymphoma Follicular, Large Cleaved Cell Type
C8997	Blastoma	Embryonal_Neoplasm|Malignant_Mixed_Neoplasm	Blastoma|Embryoma	A malignant neoplasm composed of undifferentiated cells. --2003
C8998	Medullary_Carcinoma	Carcinoma	Medullary Carcinoma
C8999	Squamous_Cell_Epithelioma	Epithelioma	Squamous Cell Epithelioma	A malignant neoplasm made up of squamous epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases.
C9003	Adrenal_Cortex_Adenoma	Adenoma|Benign_Adrenal_Cortex_Neoplasm|Benign_Endocrine_Neoplasm	Adrenal Cortex Adenoma|Adenoma of Adrenal Cortex|Adenoma of Adrenal Gland|Adenoma of the Adrenal Cortex|Adenoma of the Adrenal Gland|Adrenal Adenoma|Adrenal Cortical Adenoma|Adrenal Gland Adenoma|Adrenocortical Adenoma|Benign Adenoma of Adrenal Gland|Benign Adenoma of the Adrenal Gland|Benign Adrenal Adenoma|Benign Adrenal Gland Adenoma	A benign neoplasm that can arise from any of the adrenal cortical layers.  It can be associated with the overproduction of glucocorticoids (Cushing's syndrome), androgenic or estrogenic steroids (adrenogenital syndrome), or mineralocorticoids (Conn's syndrome). (Diagnostic Surgical Pathology, 3rd ed.)
C9004	Benign_Adrenal_Cortex_Neoplasm	Adrenal_Cortex_Neoplasm|Benign_Adrenal_Gland_Neoplasm	Benign Adrenal Cortex Neoplasm|Benign Adrenal Cortex Tumor	A non-metastasizing neoplasm arising from the adrenal cortex. (NCI05)
C9005	Malignant_Pancreatic_Neoplasm	Malignant_Gastrointestinal_Neoplasm|Pancreatic_Neoplasm	Malignant Pancreatic Neoplasm|Malignant Neoplasm of Pancreas|Malignant Neoplasm of the Pancreas	A primary or metastatic malignant tumor involving the pancreas.  Representative examples include carcinoma and lymphoma. -- 2003
C9006	Seborrheic_Keratosis	Benign_Epithelial_Skin_Neoplasm	Seborrheic Keratosis|Basal Cell Papilloma|Keratosis Seborrheica
C9007	Inverted_Follicular_Keratosis	Seborrheic_Keratosis	Inverted Follicular Keratosis
C9008	Subareolar_Duct_Papillomatosis	Papillomatosis	Subareolar Duct Papillomatosis|Papillomatosis, Subareolar Duct
C9009	Squamous_Papillomatosis	Papillomatosis	Squamous Papillomatosis
C9010	Mixed_Teratoma_and_Seminoma	Mixed_Germ_Cell_Neoplasm	Mixed Teratoma and Seminoma
C9011	Dermoid_Cyst	Cystic_Teratoma	Dermoid Cyst|Dermoid|Mature Cystic Teratoma
C9012	Adult_Cystic_Teratoma	Adult_Teratoma|Cystic_Teratoma	Adult Cystic Teratoma
C9013	Adult_Teratoma	Teratoma	Adult Teratoma
C9014	Cystic_Teratoma	Teratoma	Cystic Teratoma
C9015	Mature_Teratoma	Teratoma	Mature Teratoma
C9016	AIDS-Related_Plasmablastic_Lymphoma_of_the_Oral_Cavity	AIDS-Related_Plasmablastic_Lymphoma_of_Mucosa_Site	AIDS-Related Plasmablastic Lymphoma of the Oral Mucosa|AIDS-Related Plasmablastic Lymphoma of Oral Mucosa
C9017	AIDS-Related_Primary_Effusion_Lymphoma	AIDS-Related_Diffuse_Large_B-cell_Lymphoma|Primary_Effusion_Lymphoma	AIDS-Related Primary Effusion Lymphoma
C9018	Acute_Myeloid_Leukemia_with_inv_16_p13_q22	Acute_Myeloid_Leukemia_with_Abnormal_Marrow_Eosinophils	Acute Myeloid Leukemia with inv(16)(p13;q22)|Acute Myeloid Leukemia with inv(16)(p13;q22)(CBFb/MYH11)|Acute Myeloid Leukemia, inv(16)(p13;q22)
C9019	Acute_Myeloid_Leukemia_with_t_16_16_p13_q22	Acute_Myeloid_Leukemia_with_Abnormal_Marrow_Eosinophils	Acute Myeloid Leukemia with t(16;16)(p13;q22)|Acute Myeloid Leukemia, t(16;16)(p13;q22)
C9020	Acute_Myelomonocytic_Leukemia_with_Abnormal_Eosinophils	Acute_Myelomonocytic_Leukemia	Acute Myelomonocytic Leukemia with Abnormal Eosinophils|AMML Eo|FAB M4Eo
C9022	Childhood_Astrocytic_Tumor	Astrocytic_Tumor|Childhood_Central_Nervous_System_Neoplasm	Childhood Astrocytic Tumor|Astrocytic Tumors, Childhood|Astrocytoma, Childhood|Childhood Astrocytic Neoplasm|Childhood Astrocytic Tumour|Childhood Astrocytoma|Juvenile Astrocytoma|Pediatric Astrocytic Neoplasm|Pediatric Astrocytic Tumor|Pediatric Astrocytoma	An astrocytoma appearing before the age of twenty one without designation of benign or malignant nor designated location.
C9023	Sarcoma_by_FNCLCC_Grade	Sarcoma_of_the_Soft_Tissue_and_Bone	Sarcoma by FNCLCC Grade|FNCLCC Tumor Grade in Sarcoma|Sarcoma by FNCLCC Tumor Differentiation Score|Tumor Differentiation Score in Sarcoma
C9024	Sarcoma_Differentiation_Score_1	Sarcoma_by_FNCLCC_Grade	Sarcoma Differentiation Score 1|FNCLCC Sarcoma Grade 1|Sarcoma FNCLCC Grade 1
C9025	Well_Differentiated_Fibrosarcoma	Fibrosarcoma|Sarcoma_Differentiation_Score_1|Sarcoma_NCI_Grade_1	Well Differentiated Fibrosarcoma
C9026	Low-Grade_Malignant_Peripheral_Nerve_Sheath_Tumor	Malignant_Peripheral_Nerve_Sheath_Tumor	Low Grade Malignant Peripheral Nerve Sheath Tumor|Well Differentiated Malignant Peripheral Nerve Sheath Tumor
C9027	Well_Differentiated_Chondrosarcoma	Chondrosarcoma_NCI_Grade_1|Sarcoma_Differentiation_Score_1	Well Differentiated Chondrosarcoma
C9028	Sarcoma_Differentiation_Score_2	Sarcoma_by_FNCLCC_Grade	Sarcoma Differentiation Score 2|FNCLCC Sarcoma Grade 2|Sarcoma FNCLCC Grade 2
C9029	Sarcoma_Differentiation_Score_3	Sarcoma_by_FNCLCC_Grade	Sarcoma Differentiation Score 3|FNCLCC Sarcoma Grade 3|Sarcoma FNCLCC Grade 3
C9030	High-Grade_Malignant_Peripheral_Nerve_Sheath_Tumor	Malignant_Peripheral_Nerve_Sheath_Tumor	High Grade Malignant Peripheral Nerve Sheath Tumor|Poorly Differentiated Malignant Peripheral Nerve Sheath Tumor
C9031	Poorly_Differentiated_Angiosarcoma	Angiosarcoma|Sarcoma_Differentiation_Score_3	Poorly Differentiated Angiosarcoma
C9032	Stage_I_Adult_Hodgkin_s_Lymphoma	Adult_Hodgkin_s_Lymphoma|Stage_I_Hodgkin_s_Lymphoma	Stage I Adult Hodgkin's Lymphoma|Adult Hodgkin's Disease Stage I|Adult Hodgkin's Lymphoma Stage I|Stage I Adult Hodgkin Lymphoma|Stage I Adult Hodgkin's Disease
C9033	Stage_II_Adult_Hodgkin_s_Lymphoma	Adult_Hodgkin_s_Lymphoma|Stage_II_Hodgkin_s_Lymphoma	Stage II Adult Hodgkin's Lymphoma|Adult Hodgkin's Disease Stage II|Adult Hodgkin's Lymphoma Stage II|Stage II Adult Hodgkin Lymphoma|Stage II Adult Hodgkin's Disease
C9034	Stage_III_Adult_Hodgkin_s_Lymphoma	Adult_Hodgkin_s_Lymphoma|Stage_III_Hodgkin_s_Lymphoma	Stage III Adult Hodgkin's Lymphoma|Adult Hodgkin's Disease Stage III|Adult Hodgkin's Lymphoma Stage III|Stage III Adult Hodgkin Lymphoma|Stage III Adult Hodgkin's Disease
C9035	Stage_IV_Adult_Hodgkin_s_Lymphoma	Adult_Hodgkin_s_Lymphoma|Stage_IV_Hodgkin_s_Lymphoma	Stage IV Adult Hodgkin's Lymphoma|Adult Hodgkin's Disease Stage IV|Adult Hodgkin's Lymphoma Stage IV|Metastatic Adult Hodgkin's Lymphoma|Stage IV Adult Hodgkin Lymphoma|Stage IV Adult Hodgkin's Disease
C9036	Stage_IV_Gastric_Cancer	Gastric_Carcinoma	Stage IV Gastric Cancer|Carcinoma of Stomach Stage IV|Carcinoma of the Stomach Stage IV|Gastric Carcinoma Stage IV|Gastric Carcinoma, Stage IV|Stage IV Carcinoma of Stomach|Stage IV Carcinoma of the Stomach|Stage IV Gastric Carcinoma|Stage IV Stomach Carcinoma|Stomach Cancer Stage IV|Stomach Carcinoma Stage IV|stage IV stomach cancer	Cancer has spread to nearby tissues and to lymph nodes further away from the tumor or has spread to other parts of the body.
C9037	Stage_I_Anal_Canal_Cancer	Anal_Canal_Carcinoma	Stage I Anal Canal Cancer|Anal Cancer Stage I|Stage I Anal Cancer|Stage I Anal Carcinoma|Stage I Carcinoma of Anus|Stage I Carcinoma of the Anus|stage I anal cancer	Cancer that has spread beyond the top layer of anal tissue and is smaller than 2 centimeters (smaller than 1 inch).
C9038	Occult_Non-Small_Cell_Lung_Carcinoma	Non-Small_Cell_Lung_Carcinoma|Occult_Lung_Carcinoma	Occult Non-Small Cell Lung Carcinoma|Occult Non-Small Cell Carcinoma of Lung|Occult Non-Small Cell Carcinoma of the Lung	A non-small cell lung carcinoma detectable by sputum cytology only.  The primary tumor is undetectable radiographically or during bronchoscopy; therefore, it can not be assessed. (NCI05)
C9039	Cervical_Carcinoma	Carcinoma|Malignant_Cervical_Neoplasm	Cervical Carcinoma|Cancer of Cervix|Cancer of Uterine Cervix|Cancer of the Cervix|Cancer of the Uterine Cervix|Carcinoma of Cervix|Carcinoma of Cervix Uteri|Carcinoma of Uterine Cervix|Carcinoma of the Cervix|Carcinoma of the Cervix Uteri|Carcinoma of the Uterine Cervix|Cervical Cancer|Cervix Cancer|Cervix Carcinoma|Cervix Uteri Carcinoma|Uterine Cervix Cancer|Uterine Cervix Carcinoma	Cervical carcinoma may arise from either the exocervical squamous epithelium or the endocervical glandular epithelium.  The major histologic types of cervical carcinoma are: squamous carcinoma, adenocarcinoma, adenosquamous carcinoma, adenoid cystic carcinoma and undifferentiated carcinoma. --2002
C9040	Adult_Angiosarcoma	Angiosarcoma	Adult Angiosarcoma|Adult Hemangiosarcoma
C9041	Childhood_Infratentorial_Ependymoma	Childhood_Ependymoma|Childhood_Infratentorial_Neoplasm|Ependymal_Tumor_of_Brain	Childhood Infratentorial Ependymoma|Pediatric Infratentorial Ependymoma
C9042	Childhood_Brain_Stem_Glioma	Brain_Stem_Glioma|Childhood_Brain_Stem_Neoplasm	Childhood Brain Stem Glioma|Childhood Brainstem Glioma|Childhood Glioma of Brain Stem|Childhood Glioma of Brainstem|Childhood Glioma of the Brain Stem|Childhood Glioma of the Brainstem|Pediatric Brain Stem Glioma|Pediatric Brainstem Glioma|Pediatric Glioma of Brain Stem|Pediatric Glioma of Brainstem|Pediatric Glioma of the Brain Stem|Pediatric Glioma of the Brainstem	An abnormal growth of the cells that comprise the tissues of the brainstem. While the tumor may be histologically benign, it can produce great morbidity due to its location.  It presents most commonly in the first two decades of life.
C9043	Childhood_Supratentorial_Ependymoma	Childhood_Ependymoma|Childhood_Supratentorial_Neoplasm|Ependymal_Tumor_of_Brain	Childhood Supratentorial Ependymoma|Pediatric Supratentorial Ependymoma
C9044	Metastatic_Parathyroid_Carcinoma	Metastatic_Parathyroid_Neoplasm|Parathyroid_Carcinoma	Metastatic Parathyroid Gland Carcinoma|Metastatic Parathyroid Cancer|Metastatic Parathyroid Carcinoma	A parathyroid gland carcinoma that has spread to other anatomic sites.
C9045	Recurrent_Childhood_Central_Nervous_System_Neoplasm	Childhood_Central_Nervous_System_Neoplasm	Recurrent Childhood Central Nervous System Neoplasm|Recurrent Childhood Central Nervous System Tumor
C9046	Recurrent_Childhood_Hepatocellular_Carcinoma	Childhood_Hepatocellular_Carcinoma|Recurrent_Childhood_Liver_Cancer	Recurrent Childhood Hepatocellular Carcinoma|Recurrent Childhood Hepatoma|Recurrent Pediatric Hepatocellular Carcinoma|Recurrent Pediatric Hepatoma
C9047	Childhood_Intraocular_Retinoblastoma	Intraocular_Retinoblastoma	Childhood Intraocular Retinoblastoma|Pediatric Intraocular Retinoblastoma
C9048	Childhood_Extraocular_Retinoblastoma	Extraocular_Retinoblastoma	Childhood Extraocular Retinoblastoma|Pediatric Extraocular Retinoblastoma
C9049	Extensive_Stage_Small_Cell_Lung_Carcinoma	Small_Cell_Lung_Carcinoma	Extensive Stage Small Cell Lung Carcinoma|Extensive Stage Oat Cell Carcinoma of Lung|Extensive Stage Oat Cell Carcinoma of the Lung|Extensive Stage Oat Cell Lung Carcinoma|Extensive Stage SCLC|Extensive Stage Small Cell Carcinoma of Lung|Extensive Stage Small Cell Carcinoma of the Lung|Small Cell Lung Cancer, Extensive Stage|extensive-stage small cell lung cancer	Cancer that has spread outside the lung to other tissues in the chest or to other parts of the body.
C9050	Recurrent_Small_Cell_Lung_Carcinoma	Recurrent_Lung_Cancer|Small_Cell_Lung_Carcinoma	Recurrent Small Cell Lung Carcinoma|Recurrent Small Cell Carcinoma of Lung|Recurrent Small Cell Carcinoma of the Lung|Recurrent Small Cell Lung Cancer|Relapsed Small Cell Carcinoma of Lung|Relapsed Small Cell Carcinoma of the Lung|Relapsed Small Cell Lung Cancer|Relapsed Small Cell Lung Carcinoma	The reemergence of small cell carcinoma of the lung after a period of remission. --2003
C9051	Stage_II_Vulvar_Cancer	Vulvar_Carcinoma	Stage II Vulvar Cancer|AJCC Stage II Vulva Cancer|FIGO Stage II Carcinoma of Vulva|FIGO Stage II Carcinoma of the Vulva|FIGO Stage II Vulva Carcinoma|FIGO Stage II Vulvar Carcinoma|Stage II Vulva Cancer|Vulva Cancer Stage II|Vulval Cancer Stage II|stage II cancer of the vulva	Cancer that is found in the vulva, the space between the opening of the rectum and the vagina (perineum), or both.  The tumor is larger than 2 centimeters (larger than 1 inch).
C9052	Stage_III_Vulvar_Cancer	Vulvar_Carcinoma	Stage III Vulvar Cancer|AJCC Stage III Vulva Cancer|FIGO Stage III Carcinoma of Vulva|FIGO Stage III Carcinoma of the Vulva|FIGO Stage III Vulva Carcinoma|FIGO Stage III Vulvar Carcinoma|Stage III Vulva Cancer|Vulva Cancer Stage III|Vulval Cancer Stage III|stage III cancer of the vulva	Cancer is found in the vulva, perineum, or both. The cancer has also spread to nearby tissues such as the lower part of the urethra (the tube through which urine passes), the vagina, and the anus (the opening of the rectum); to nearby lymph nodes; or both.
C9053	Stage_IV_Vulvar_Cancer	Vulvar_Carcinoma	Stage IV Vulvar Cancer|AJCC Stage IV Vulva Cancer|FIGO Stage IV Carcinoma of Vulva|FIGO Stage IV Carcinoma of the Vulva|FIGO Stage IV Vulva Carcinoma|FIGO Stage IV Vulvar Carcinoma|Stage IV Vulva Cancer|Vulva Cancer Stage IV|Vulval Cancer Stage IV|stage IV cancer of the vulva	Cancer has spread beyond the urethra, vagina, and anus into the lining of the bladder (the sac that holds urine) and the bowel (intestine); or it may have spread to the lymph nodes in the pelvis or to other parts of the body.
C9054	Recurrent_Vulvar_Cancer	Recurrent_Female_Reproductive_System_Cancer|Vulvar_Carcinoma	Recurrent Vulvar Cancer|Recurrent Cancer of Vulva|Recurrent Cancer of the Vulva|Recurrent Vulva Cancer|Recurrent Vulvar Carcinoma|Relapsed Cancer of Vulva|Relapsed Cancer of the Vulva|Relapsed Vulva Cancer|Relapsed Vulvar Cancer	Cancer that recurs after a period of remission following treatment for vulval cancer.  It may come back in the vulva or another place.
C9055	Bartholin_s_Gland_Carcinoma	Bartholin_s_Gland_Neoplasm|Vulvar_Carcinoma	Bartholin's Gland Carcinoma|Bartholin's Gland Cancer|Carcinoma of Bartholin's Gland|Carcinoma of the Bartholin's Gland
C9056	Stage_I_Childhood_Lymphoblastic_Lymphoma	Childhood_Lymphoblastic_Lymphoma	Stage I Childhood Lymphoblastic Lymphoma|Childhood Lymphoblastic Lymphoma Stage I|Pediatric Lymphoblastic Lymphoma Stage I|Stage I Pediatric Lymphoblastic Lymphoma
C9057	Stage_II_Childhood_Lymphoblastic_Lymphoma	Childhood_Lymphoblastic_Lymphoma	Stage II Childhood Lymphoblastic Lymphoma|Childhood Lymphoblastic Lymphoma Stage II|Pediatric Lymphoblastic Lymphoma Stage II|Stage II Pediatric Lymphoblastic Lymphoma
C9058	Stage_III_Childhood_Lymphoblastic_Lymphoma	Childhood_Lymphoblastic_Lymphoma	Stage III Childhood Lymphoblastic Lymphoma|Childhood Lymphoblastic Lymphoma Stage III|Pediatric Lymphoblastic Lymphoma Stage III|Stage III Pediatric Lymphoblastic Lymphoma
C9059	Stage_IV_Childhood_Lymphoblastic_Lymphoma	Childhood_Lymphoblastic_Lymphoma	Stage IV Childhood Lymphoblastic Lymphoma|Childhood Lymphoblastic Lymphoma Stage IV|Childhood Stage IV Lymphoblastic Lymphoma|Metastatic Childhood Lymphoblastic Lymphoma|Metastatic Pediatric Lymphoblastic Lymphoma|Pediatric Lymphoblastic Lymphoma Stage IV|Pediatric Stage IV Lymphoblastic Lymphoma|Stage IV Pediatric Lymphoblastic Lymphoma
C9060	Recurrent_Childhood_Lymphoblastic_Lymphoma	Childhood_Lymphoblastic_Lymphoma|Recurrent_Non-Hodgkin_s_Lymphoma	Recurrent Childhood Lymphoblastic Lymphoma|Recurrent Pediatric Lymphoblastic Lymphoma|Relapsed Childhood Lymphoblastic Lymphoma|Relapsed Pediatric Lymphoblastic Lymphoma
C9061	Penile_Carcinoma	Carcinoma|Malignant_Penile_Neoplasm	Penile Carcinoma|Cancer of Penis|Cancer of the Penis|Carcinoma of Penis|Carcinoma of the Penis|Penile Cancer	Tumors of the penis make up approximately 1% to 1.5% of cancers in the male population in the United States and Europe.  Risk factors include: phimosis (narrowing of the foreskin or prepuce) and Human Papilloma Viruses.  The majority of penile cancers are squamous cell carcinomas.  The most frequent clinical presentation is an irregular mass in the glans of the penis. Treatment includes: surgical management, radiation therapy (external beam and brachytherapy). - 2002
C9062	Adult_Burkitt_s_Lymphoma	Adult_Non-Hodgkin_s_Lymphoma|Burkitt_s_Lymphoma	Adult Burkitt's Lymphoma|Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma|Adult Small Non-Cleaved Cell Lymphoma
C9063	Malignant_Testicular_Germ_Cell_Tumor	Malignant_Germ_Cell_Neoplasm|Malignant_Testicular_Neoplasm|Testicular_Germ_Cell_Neoplasm	Malignant Testicular Germ Cell Tumor|Malignant Germ Cell Neoplasm of Testis|Malignant Germ Cell Neoplasm of the Testis|Malignant Germ Cell Tumor of Testis|Malignant Germ Cell Tumor of the Testis|Malignant Testicular Germ Cell Neoplasm|Testicular Cancer|Testicular Carcinoma|Testicular Germ Cell Cancer	A malignant tumor predominantly affecting young men and often associated with cryptorchidism.  Seminoma is the most frequently seen malignant testicular germ cell tumor, followed by embryonal carcinoma and yolk sac tumor. -- 2004
C9064	Localized_Resectable_Adult_Primary_Hepatoma	Adult_Hepatocellular_Carcinoma|Localized_Resectable_Adult_Liver_Cancer|Resectable_Hepatocellular_Carcinoma	Localized Resectable Adult Hepatocellular Carcinoma
C9065	Localized_Unresectable_Adult_Primary_Hepatoma	Adult_Hepatocellular_Carcinoma|Localized_Unresectable_Adult_Liver_Cancer|Non-Resectable_Hepatocellular_Carcinoma	Localized Unresectable Adult Hepatocellular Carcinoma
C9067	Recurrent_Adult_Primary_Hepatoma	Recurrent_Adult_Liver_Cancer|Recurrent_Hepatocellular_Carcinoma	Recurrent Adult Hepatocellular Carcinoma
C9068	Recurrent_Childhood_Acute_Myeloid_Leukemia	Childhood_Acute_Myeloid_Leukemia|Relapsed_Hematologic_Malignancy	Recurrent Childhood Acute Myeloid Leukemia|Recurrent Childhood AML|Recurrent Childhood Acute Myeloblastic Leukemia|Recurrent Childhood Acute Myelocytic Leukemia|Recurrent Childhood Acute Myelogenous Leukemia|Recurrent Childhood Acute Non-Lymphocytic Leukemia|Recurrent Pediatric AML|Recurrent Pediatric Acute Myeloblastic Leukemia|Recurrent Pediatric Acute Myelocytic Leukemia|Recurrent Pediatric Acute Myelogenous Leukemia|Recurrent Pediatric Acute Myeloid Leukemia|Relapsed Childhood AML|Relapsed Childhood Acute Myeloblastic Leukemia|Relapsed Childhood Acute Myelocytic Leukemia|Relapsed Childhood Acute Myelogenous Leukemia|Relapsed Childhood Acute Myeloid Leukemia|Relapsed Pediatric AML|Relapsed Pediatric Acute Myeloblastic Leukemia|Relapsed Pediatric Acute Myelocytic Leukemia|Relapsed Pediatric Acute Myelogenous Leukemia|Relapsed Pediatric Acute Myeloid Leukemia
C9069	Pancreatic_G-Cell_Gastrin_Producing_Neoplasm	Functioning_Pancreatic_Endocrine_Neoplasm|G-Cell_Gastrin_Producing_Neoplasm	Pancreatic Gastrin Producing Tumor|Islet Cell Gastrinoma|Pancreatic G-Cell Tumor|Pancreatic Gastrin Producing Neoplasm|Pancreatic Gastrinoma	A usually malignant pancreatic endocrine neoplasm, characterised by inappropriate secretion of gastrin.  It is associated with Zollinger Ellison syndrome.  The latter is characterised by the presence of peptic ulcer, gastroesophageal reflux disease, abdominal pain, diarrhea, and malabsorption. -- 2005
C9070	Relapsed_Chronic_Myelogenous_Leukemia	Chronic_Myelogenous_Leukemia|Relapsed_Hematologic_Malignancy	Recurrent Chronic Myelogenous Leukemia|Relapsed CGL|Relapsed CML|Relapsed Chronic Myelogenous Leukemia
C9071	Stage_0_Endometrial_Cancer	Endometrial_Carcinoma	Stage 0 Endometrial Cancer|Endometrial Carcinoma in situ	Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)- 2003
C9072	Recurrent_Endometrial_Carcinoma	Endometrial_Carcinoma|Recurrent_Female_Reproductive_System_Cancer	Recurrent Endometrial Cancer|Recurrent Cancer of Endometrium|Recurrent Cancer of the Endometrium|Recurrent Carcinoma of Endometrium|Recurrent Carcinoma of the Endometrium|Recurrent Endometrial Carcinoma|Relapsed Cancer of Endometrium|Relapsed Cancer of the Endometrium|Relapsed Carcinoma of Endometrium|Relapsed Carcinoma of the Endometrium|Relapsed Endometrial Cancer|Relapsed Endometrial Carcinoma	Reemerging endometrial cancer after a period of remission.
C9073	Stage_II_Testicular_Cancer	Malignant_Testicular_Germ_Cell_Tumor	Stage II Testicular Cancer|Stage II Cancer of Testis|Stage II Cancer of the Testis|Stage II Testicular Germ Cell Tumor|stage II testicular cancer	Cancer has spread to the lymph nodes in the abdomen.
C9074	Stage_III_Testicular_Cancer	Malignant_Testicular_Germ_Cell_Tumor	Stage III Testicular Cancer|Stage III Cancer of Testis|Stage III Cancer of the Testis|Stage III Testicular Carcinoma|Stage III Testicular Germ Cell Tumor|stage III testicular cancer	Cancer has spread beyond the lymph nodes in the abdomen. There may be cancer in parts of the body far away from the testicles.
C9075	Stage_IV_Prostate_Cancer	Prostate_Carcinoma	Stage IV Prostate Cancer|Cancer of Prostate Stage IV|Cancer of the Prostate Stage IV|Prostate Cancer Stage IV|Prostate Carcinoma Stage IV|Stage IV Cancer of Prostate|Stage IV Cancer of the Prostate|Stage IV Prostate Carcinoma|Stage IV Prostatic Cancer|Stage IV Prostatic Carcinoma|stage IV prostate cancer	Cancer cells have spread to lymph nodes (near or far from the prostate) or to organs and tissues far away from the prostate such as the bone, liver, or lungs. Similar to stage D in the Whitmore-Jewett staging system.
C9076	Childhood_Diffuse_Large_Cell_Lymphoma	Childhood_Large_Cell_Lymphoma	Childhood Diffuse Large Cell Lymphoma|Pediatric Diffuse Large Cell Lymphoma
C9077	Refractory_Testicular_Cancer	Malignant_Testicular_Germ_Cell_Tumor	Refractory Testicular Cancer|Refractory Cancer of Testis|Refractory Cancer of the Testis|Refractory Carcinoma of Testis|Refractory Carcinoma of the Testis|Refractory Testicular Carcinoma
C9079	Childhood_Immunoblastic_Lymphoma	Childhood_Diffuse_Large_B_Cell_Lymphoma|Immunoblastic_Lymphoma	Childhood Immunoblastic Lymphoma|Childhood Immunoblastic Large Cell Lymphoma|Pediatric Immunoblastic Large Cell Lymphoma|Pediatric Immunoblastic Lymphoma
C9080	Noninvasive_Malignant_Thymoma	Malignant_Thymoma	Noninvasive Malignant Thymoma|Malignant Thymoma, Noninvasive|Thymoma Malignant Noninvasive	A morphologically malignant thymoma that is entirely confined within the capsule.  --2003
C9081	Stage_I_Thyroid_Papillary_Carcinoma	Papillary_Thyroid_Carcinoma	Stage I Thyroid Gland Papillary Carcinoma|Stage I Papillary Carcinoma of Thyroid|Stage I Papillary Carcinoma of Thyroid Gland|Stage I Papillary Carcinoma of the Thyroid|Stage I Papillary Carcinoma of the Thyroid Gland|Stage I Papillary Thyroid Cancer|Stage I Papillary Thyroid Gland Carcinoma|Stage I Thyroid Papillary Carcinoma
C9082	Stage_II_Thyroid_Papillary_Carcinoma	Papillary_Thyroid_Carcinoma	Stage II Thyroid Gland Papillary Carcinoma|Stage II Papillary Carcinoma of Thyroid|Stage II Papillary Carcinoma of Thyroid Gland|Stage II Papillary Carcinoma of the Thyroid|Stage II Papillary Carcinoma of the Thyroid Gland|Stage II Papillary Thyroid Cancer|Stage II Papillary Thyroid Gland Carcinoma|Stage II Thyroid Papillary Carcinoma
C9083	Stage_IV_Thyroid_Papillary_Carcinoma	Papillary_Thyroid_Carcinoma	Stage IV Thyroid Gland Papillary Carcinoma|Metastatic Papillary Carcinoma of Thyroid|Metastatic Papillary Carcinoma of Thyroid Gland|Metastatic Papillary Carcinoma of the Thyroid|Metastatic Papillary Carcinoma of the Thyroid Gland|Metastatic Thyroid Gland Papillary Carcinoma|Metastatic Thyroid Papillary Carcinoma|Stage IV Papillary Carcinoma of Thyroid|Stage IV Papillary Carcinoma of Thyroid Gland|Stage IV Papillary Carcinoma of the Thyroid|Stage IV Papillary Carcinoma of the Thyroid Gland|Stage IV Papillary Thyroid Cancer|Stage IV Papillary Thyroid Gland Carcinoma|Stage IV Thyroid Papillary Carcinoma
C9084	Stage_I_Thyroid_Follicular_Carcinoma	Follicular_Thyroid_Carcinoma	Stage I Thyroid Gland Follicular Carcinoma|Stage I Follicular Carcinoma of Thyroid|Stage I Follicular Carcinoma of Thyroid Gland|Stage I Follicular Carcinoma of the Thyroid|Stage I Follicular Carcinoma of the Thyroid Gland|Stage I Follicular Thyroid Gland Carcinoma|Stage I Thyroid Follicular Cancer|Stage I Thyroid Follicular Carcinoma
C9085	Stage_II_Thyroid_Follicular_Carcinoma	Follicular_Thyroid_Carcinoma	Stage II Thyroid Gland Follicular Carcinoma|Stage II Follicular Carcinoma of Thyroid|Stage II Follicular Carcinoma of Thyroid Gland|Stage II Follicular Carcinoma of the Thyroid|Stage II Follicular Carcinoma of the Thyroid Gland|Stage II Follicular Thyroid Gland Carcinoma|Stage II Thyroid Follicular Cancer|Stage II Thyroid Follicular Carcinoma
C9086	Stage_IV_Thyroid_Follicular_Carcinoma	Follicular_Thyroid_Carcinoma	Stage IV Thyroid Gland Follicular Carcinoma|Metastatic Follicular Carcinoma of Thyroid|Metastatic Follicular Carcinoma of Thyroid Gland|Metastatic Follicular Carcinoma of the Thyroid|Metastatic Follicular Carcinoma of the Thyroid Gland|Metastatic Thyroid Follicular Carcinoma|Metastatic Thyroid Gland Follicular Carcinoma|Stage IV Follicular Carcinoma of Thyroid|Stage IV Follicular Carcinoma of Thyroid Gland|Stage IV Follicular Carcinoma of the Thyroid|Stage IV Follicular Carcinoma of the Thyroid Gland|Stage IV Follicular Thyroid Gland Carcinoma|Stage IV Thyroid Follicular Cancer|Stage IV Thyroid Follicular Carcinoma
C9087	Kaposi_s_Sarcoma	Human_Herpes_Virus_8-Related_Malignant_Neoplasm|Malignant_Blood_Vessel_Neoplasm|Soft_Tissue_Sarcoma|Virus-Related_Sarcoma	Kaposi's Sarcoma|KS|Kaposi - Kaposi's Sarcoma|Kaposi Sarcoma|Kaposi's sarcoma|Multiple Hemorrhagic Sarcoma	(KAP-o-seez sar-KO-ma) A type of cancer characterized by the abnormal growth of blood vessels that develop into skin lesions or occur internally.
C9088	Iris_Melanoma	Malignant_Iris_Neoplasm|Uveal_Melanoma	Iris Melanoma|Iris Malignant Melanoma|Malignant Melanoma of Iris|Malignant Melanoma of the Iris|Melanoma of Iris|Melanoma of the Iris
C9089	Small_Size_Posterior_Uveal_Melanoma	Uveal_Melanoma	Small Size Posterior Uveal Melanoma
C9090	Medium_Large_Size_Posterior_Uveal_Melanoma	Uveal_Melanoma	Medium/Large Size Posterior Uveal Melanoma
C9091	Adult_Brain_Stem_Glioma	Adult_Brain_Stem_Neoplasm|Brain_Stem_Glioma	Adult Brain Stem Glioma|Adult Brainstem Glioma|Adult Brainstem Neuroglial Neoplasm|Adult Brainstem Neuroglial Tumor|Glioma of Adult Brain Stem|Glioma of the Adult Brain Stem
C9092	Adult_Ependymoma	Adult_Central_Nervous_System_Neoplasm|Ependymoma	Adult Ependymoma|Adult Well-Differentiated Ependymoma|Well-Differentiated Adult Ependymoma
C9093	Adult_Meningioma	Adult_Central_Nervous_System_Neoplasm|Meningioma	Adult Meningioma
C9094	Adult_Glioblastoma	Adult_Astrocytic_Tumor|Glioblastoma	Adult Glioblastoma|Adult Glioblastoma Multiforme|Grade IV Adult Astrocytic Neoplasm|Grade IV Adult Astrocytic Tumor|Grade IV Adult Astrocytoma
C9095	Childhood_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma|Childhood_Non-Hodgkin_s_Lymphoma	Childhood Burkitt's Lymphoma|Childhood Small Non-Cleaved Cell Lymphoma|Pediatric Burkitt's Lymphoma|Pediatric Small Non-Cleaved Cell Lymphoma
C9096	Stage_IV_Melanoma_of_the_Skin	Cutaneous_Melanoma	Stage IV Skin Melanoma|Malignant Melanoma (of Skin), Stage IV|Metastatic Cutaneous Melanoma|Stage IV Cutaneous Malignant Melanoma|Stage IV Cutaneous Melanoma|Stage IV Malignant Melanoma of Skin|Stage IV Malignant Melanoma of the Skin|Stage IV Malignant Skin Melanoma|Stage IV Melanoma of Skin|Stage IV Melanoma of the Skin|stage IV melanoma	Stage IV includes: (Any T, Any N, M1).  M1: Distant metastasis. - 2003
C9097	Recurrent_Melanoma_of_the_Skin	Cutaneous_Melanoma|Recurrent_Melanoma	Recurrent Melanoma of the Skin|Recurrent Cutaneous Melanoma|Recurrent Malignant Melanoma of Skin|Recurrent Malignant Melanoma of the Skin|Recurrent Malignant Skin Melanoma|Recurrent Melanoma of Skin
C9098	Low-Grade_Adult_Non-Hodgkin_s_Lymphoma	Adult_Non-Hodgkin_s_Lymphoma_Grade|Low-Grade_Lymphoma	Low Grade Adult Non-Hodgkin's Lymphoma
C9099	Stage_0_Nasopharyngeal_Carcinoma	Nasopharyngeal_Carcinoma	Stage 0 Nasopharyngeal Carcinoma|Carcinoma in situ of Nasopharynx|Carcinoma in situ of the Nasopharynx|Nasopharyngeal Carcinoma in situ|Stage 0 Carcinoma of Nasopharynx|Stage 0 Carcinoma of the Nasopharynx|Stage 0 Nasopharyngeal Cancer|Stage 0 Nasopharynx Carcinoma	Stage 0 includes: (Tis, N0,M0).  Tis: Carcinoma in situ. N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003
C9100	Stage_0_Laryngeal_Cancer	Carcinoma_in_situ|Laryngeal_Carcinoma	Stage 0 Laryngeal Cancer|Carcinoma in situ of Larynx|Carcinoma in situ of the Larynx|Laryngeal Cancer Stage 0|Laryngeal Carcinoma Stage 0|Laryngeal Carcinoma in situ|Larynx Carcinoma in situ|Stage 0 Carcinoma of Larynx|Stage 0 Carcinoma of the Larynx|Stage 0 Laryngeal Carcinoma|Stage 0 Larynx Carcinoma	Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003
C9101	Stage_0_Hypopharyngeal_Cancer	Hypopharyngeal_Carcinoma	Stage 0 Hypopharyngeal Cancer|Carcinoma in situ of Hypopharynx|Carcinoma in situ of the Hypopharynx|Hypopharyngeal Carcinoma in situ|Hypopharynx Carcinoma in situ|Stage 0 Carcinoma of Hypopharynx|Stage 0 Carcinoma of the Hypopharynx|Stage 0 Hypopharyngeal Carcinoma|Stage 0 Hypopharynx Carcinoma	Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003
C9102	Stage_IIIA_Non-Small_Cell_Lung_Cancer	Stage_IIIA_Lung_Carcinoma|Stage_III_Non-Small_Cell_Lung_Cancer	Stage IIIA Non-Small Cell Lung Cancer|Non Small Cell Lung Cancer Stage IIIA|Non Small Cell Lung Cancer, Stage IIIA|Stage IIIA NSCLC|Stage IIIA Non-Oat Cell Carcinoma of Lung|Stage IIIA Non-Oat Cell Carcinoma of the Lung|Stage IIIA Non-Oat Cell Lung Carcinoma|Stage IIIA Non-Small Cell Carcinoma of Lung|Stage IIIA Non-Small Cell Carcinoma of the Lung|Stage IIIA Non-Small Cell Lung Carcinoma	Stage 3a includes T1 or T2,N2,MO/T3,N1 or N2,MO. N2: Metastasis to ipsilateral mediastinal and/or subcarinal lymph node(s).
C9103	Stage_IIIB_Non-Small_Cell_Lung_Cancer	Stage_IIIB_Lung_Carcinoma|Stage_III_Non-Small_Cell_Lung_Cancer	Stage IIIB Non-Small Cell Lung Cancer|Non Small Cell Lung Cancer Stage IIIB|Non Small Cell Lung Cancer, Stage IIIB|Stage IIIB NSCLC|Stage IIIB Non-Oat Cell Carcinoma of Lung|Stage IIIB Non-Oat Cell Carcinoma of the Lung|Stage IIIB Non-Oat Cell Lung Carcinoma|Stage IIIB Non-Small Cell Carcinoma of Lung|Stage IIIB Non-Small Cell Carcinoma of the Lung|Stage IIIB Non-Small Cell Lung Carcinoma	Stage 3b includes anyT,N3,MO/T4,anyN,MO. T4: A tumor of any size that invades any of the following: mediastinum, heart, great vessels, trachea, esophagus, vertebral body, carina; or separate tumor nodules in the same lobe; or tumor with a malignant pleural effusion. N3: Metastasis to contralateral mediastinal, contralateral hilar, ipsilateral or contralateral scalene, or supraclavicular lymph node(s).
C9104	Stage_0_Non-Small_Cell_Lung_Cancer	Non-Small_Cell_Lung_Carcinoma|Stage_0_Lung_Cancer	Stage 0 Non-Small Cell Lung Cancer|Lung Non-Small Cell Carcinoma in situ|Non-Small Cell Carcinoma in situ of Lung|Non-Small Cell Carcinoma in situ of the Lung|Stage 0 NSCLC|Stage 0 Non-Small Cell Carcinoma of Lung|Stage 0 Non-Small Cell Carcinoma of the Lung|Stage 0 Non-Small Cell Lung Carcinoma	Stage 0 includes Tis,NO,MO.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis.
C9105	Oropharyngeal_Carcinoma	Malignant_Oropharyngeal_Neoplasm|Pharyngeal_Carcinoma	Oropharyngeal Carcinoma|Cancer of Oropharynx|Cancer of the Oropharynx|Carcinoma of Oropharynx|Carcinoma of the Oropharynx|Oropharyngeal Cancer|Oropharynx Carcinoma	Carcinoma, predominantly squamous cell, arising from epithelial cells of the oropharynx. -- 2004
C9106	Urethral_Carcinoma	Carcinoma|Infrequent_Neoplasm|Malignant_Urethral_Neoplasm	Urethral Carcinoma|Carcinoma of Urethra|Carcinoma of the Urethra|Urethra Carcinoma|Urethral Cancer	Abnormal malignant growth of cells in the urethra (lower urinary tract).
C9107	Childhood_Solid_Neoplasm	Childhood_Neoplasm|Solid_Neoplasm	Childhood Solid Neoplasm|Childhood Solid Tumor|Pediatric Solid Tumor
C9108	Intermediate-Grade_Adult_Non-Hodgkin_s_Lymphoma	Adult_Non-Hodgkin_s_Lymphoma_Grade|Intermediate-Grade_Lymphoma	Intermediate Grade Adult Non-Hodgkin's Lymphoma
C9109	High-Grade_Adult_Non-Hodgkin_s_Lymphoma	Adult_Non-Hodgkin_s_Lymphoma_Grade|High-Grade_Lymphoma	High Grade Adult Non-Hodgkin's Lymphoma
C9110	Blast_Phase_Chronic_Myelogenous_Leukemia	Chronic_Myelogenous_Leukemia	Blast Phase Chronic Myelogenous Leukemia|Blast Phase CML|Blast Phase Chronic Granulocytic Leukemia|Blast Phase Chronic Myelocytic Leukemia|Blast Phase Chronic Myeloid Leukemia|Blastic Phase CML|Blastic Phase Chronic Granulocytic Leukemia|Blastic Phase Chronic Myelocytic Leukemia|Blastic Phase Chronic Myelogenous Leukemia|Blastic Phase Chronic Myeloid Leukemia|blast crisis|blast phase	Refers to advanced chronic myelogenous leukemia. In this phase, the number of immature, abnormal white blood cells in the bone marrow and blood is extremely high. Also called blast crisis.
C9111	Meningeal_Chronic_Myelogenous_Leukemia	Central_Nervous_System_Leukemia|Chronic_Myelogenous_Leukemia|Malignant_Neoplasms_of_the_Meninges	Meningeal Chronic Myelogenous Leukemia
C9112	Classic_Kaposi_s_Sarcoma	Kaposi_s_Sarcoma	Classic Kaposi's Sarcoma|Kaposi Sarcoma Classical Type|Kaposi Sarcoma, Classic|Kaposi's Sarcoma, Classical Type	This is a vascular sarcoma that commonly occurs in the lower extremities.  It occurs predominantly in elderly male patients of southern European ancestry.  This disease is usually slow growing, although it can spread to the lungs and the gastrointestinal tract.  If found necessary cutaneous lesions can be treated with radiation. - 2003
C9113	Kaposi_s_Sarcoma_Related_to_Immunosuppressive_Treatment	Kaposi_s_Sarcoma	Kaposi's Sarcoma Related to Immunosuppressive Treatment|Immunosuppressive Treatment Related Kaposi Sarcoma|Immunosuppressive Treatment Related Kaposi's Sarcoma
C9114	Adult_Acute_Leukemia_in_Remission	Acute_Leukemia_in_Remission	Adult Acute Leukemia in Remission
C9115	Childhood_Acute_Myeloid_Leukemia_in_Remission	Acute_Myeloid_Leukemia_in_Remission|Childhood_Acute_Leukemia_in_Remission|Childhood_Myeloid_Leukemia_in_Remission	Childhood Acute Myeloid Leukemia in Remission|Childhood AML in Remission|Childhood Acute Granulocytic Leukemia in Remission|Childhood Acute Myeloblastic Leukemia in Remission|Childhood Acute Myelocytic Leukemia in Remission|Childhood Acute Myelogenous Leukemia in Remission|Pediatric AML in Remission|Pediatric Acute Granulocytic Leukemia in Remission|Pediatric Acute Myeloblastic Leukemia in Remission|Pediatric Acute Myelocytic Leukemia in Remission|Pediatric Acute Myelogenous Leukemia in Remission|Pediatric Acute Myeloid Leukemia in Remission
C9116	Childhood_Acute_Leukemia_in_Remission	Acute_Leukemia_in_Remission	Childhood Acute Leukemia in Remission
C9117	Recurrent_Metastatic_Squamous_Cell_Carcinoma_to_the_Neck_with_Occult_Primary	Squamous_Cell_Carcinoma_Metastatic_to_the_Neck_with_Occult_Primary	Recurrent Metastatic Squamous Cell Carcinoma to the Neck with Occult Primary|Recurrent Metastatic Epidermoid Carcinoma to the Neck with Occult Primary|Recurrent Metastatic Squamous Cell Cancer to the Neck with Occult Primary|Relapsed Metastatic Epidermoid Carcinoma to the Neck with Occult Primary|Relapsed Metastatic Squamous Cell Carcinoma to the Neck with Occult Primary|Relapsed Metastatic Squamous Cell Neck Cancer with Occult Primary
C9118	Sarcoma_of_the_Soft_Tissue_and_Bone	Mesenchymal_Cell_Neoplasm	Sarcoma of the Soft Tissue and Bone|Sarcoma|Sarcoma of Soft Tissue and Bone|sarcoma	A cancer of the bone, cartilage, fat, muscle, blood vessels, or other connective or supportive tissue.
C9119	Medullary_Breast_Carcinoma	Breast_Adenocarcinoma|Invasive_Breast_Carcinoma|Medullary_Carcinoma	Medullary Breast Carcinoma|Infiltrating Medullary Carcinoma of Breast|Infiltrating Medullary Carcinoma of the Breast|Invasive Medullary Breast Carcinoma|Invasive Medullary Carcinoma of Breast|Invasive Medullary Carcinoma of the Breast|Medullary Breast Carcinoma with Lymphoid Stroma|Medullary Carcinoma of Breast|Medullary Carcinoma of the Breast|medullary breast carcinoma	(MED-yoo-LAIR-ee) A rare type of breast cancer that often can be treated successfully. It is marked by lymphocytes (a type of white blood cell) in and around the tumor that can be seen when viewed under a microscope.
C9120	Pancreatic_Ductal_Adenocarcinoma	Pancreatic_Adenocarcinoma	Pancreatic Ductal Adenocarcinoma|Ductal Adenocarcinoma of Pancreas|Ductal Adenocarcinoma of the Pancreas|Pancreas Ductal Adenocarcinoma	A carcinoma occurring almost exclusively in adults that probably arises from the pancreatic duct epithelium.  Most pancreatic carcinomas are ductal adenocarcinomas of which about two-thirds involve the head, with the remainder in the body and tail of the pancreas.  The patients are usually over 50 years of age.  Pain, jaundice, and loss of weight are the most common manifestations.  Ductal adenocarcinomas usually grow rapidly and are discovered after they have already spread beyond the pancreas.  Grossly, ductal adenocarcinomas are firm and poorly defined masses.  Microscopically, most ductal adenocarcinomas are characterized by well-developed glandular structures embedded in a desmoplastic stroma.  Ductal adenocarcinomas are fatal in the vast majority of cases (WHO 2000). --2002
C9121	Stage_III_Thyroid_Follicular_Carcinoma	Follicular_Thyroid_Carcinoma	Stage III Thyroid Gland Follicular Carcinoma|Stage III Follicular Carcinoma of Thyroid|Stage III Follicular Carcinoma of Thyroid Gland|Stage III Follicular Carcinoma of the Thyroid|Stage III Follicular Carcinoma of the Thyroid Gland|Stage III Follicular Thyroid Gland Carcinoma|Stage III Thyroid Follicular Carcinoma
C9122	Stage_III_Thyroid_Papillary_Carcinoma	Papillary_Thyroid_Carcinoma	Stage III Thyroid Gland Papillary Carcinoma|Stage III Papillary Carcinoma of Thyroid|Stage III Papillary Carcinoma of Thyroid Gland|Stage III Papillary Carcinoma of the Thyroid|Stage III Papillary Carcinoma of the Thyroid Gland|Stage III Papillary Thyroid Gland Carcinoma|Stage III Thyroid Papillary Carcinoma
C9123	Ovarian_Mixed_Epithelial_Carcinoma	Malignant_Ovarian_Mixed_Epithelial_Tumor|Ovarian_Carcinoma	Ovarian Mixed Epithelial Carcinoma|Mixed Epithelial Carcinoma of Ovary|Mixed Epithelial Carcinoma of the Ovary
C9124	Childhood_Lymphoblastic_Lymphoma	Childhood_Non-Hodgkin_s_Lymphoma|Precursor_Lymphoblastic_Lymphoma	Childhood Lymphoblastic Lymphoma|Pediatric Lymphoblastic Lymphoma
C9125	Adult_Lymphocyte_Depleted_Hodgkin_s_Lymphoma	Adult_Hodgkin_s_Lymphoma|Lymphocyte_Depleted_Hodgkin_s_Lymphoma	Adult Lymphocyte Depleted Hodgkin's Lymphoma|Adult HDLD|Adult LDHD|Adult Lymphocyte Depletion Hodgkin's Disease
C9126	Adult_Nodular_Sclerosis_Hodgkin_s_Lymphoma	Adult_Hodgkin_s_Lymphoma|Nodular_Sclerosis_Hodgkin_s_Lymphoma	Adult Nodular Sclerosis Hodgkin's Lymphoma|Adult Hodgkin's Nodular Sclerosis|Adult NSHD|Adult Nodular Sclerosis Hodgkin Lymphoma|Adult Nodular Sclerosis Hodgkin's Disease
C9127	Adult_Mixed_Cellularity_Hodgkin_s_Lymphoma	Adult_Hodgkin_s_Lymphoma|Mixed_Cellularity_Hodgkin_s_Lymphoma	Adult Mixed Cellularity Hodgkin's Lymphoma|Adult HDMC|Adult MCHD|Adult Mixed Cellularity Hodgkin Lymphoma|Adult Mixed Cellularity Hodgkin's Disease
C9128	Philadelphia_Chromosome_Positive_Chronic_Myelogenous_Leukemia	Chronic_Myelogenous_Leukemia|Philadelphia-Positive_Myelogenous_Leukemia	Philadelphia Chromosome Positive Chronic Myelogenous Leukemia|Chronic Myeloid Leukemia t(9;22) (q34;q11), BCR/ABL Positive|Ph' Chromosome Positive Chronic Myelocytic Leukemia|Ph' Chromosome Positive Chronic Myelogenous Leukemia|Ph' Chromosome Positive Chronic Myeloid Leukemia|Ph' Positive Chronic Granulocytic Leukemia|Ph1 Chromosome Positive Chronic Myelocytic Leukemia|Ph1 Chromosome Positive Chronic Myelogenous Leukemia|Ph1 Chromosome Positive Chronic Myeloid Leukemia|Ph1 Positive Chronic Granulocytic Leukemia|Philadelphia Chromosome Positive CML|Philadelphia Chromosome Positive Chronic Granulocytic Leukemia|Philadelphia Chromosome Positive Chronic Myelocytic Leukemia|Philadelphia Chromosome Positive Chronic Myeloid Leukemia	A chronic myelogenous leukemia characterised by the t(9;22)(q34;q11) chromosomal translocation, resulting in the presence of the Philadelphia chromosome. -- 2003
C9129	Philadelphia_Chromosome_Negative_Chronic_Myelogenous_Leukemia	Chronic_Myelogenous_Leukemia|Philadelphia-Negative_Myelogenous_Leukemia	Philadelphia Chromosome Negative Chronic Myelogenous Leukemia|Ph Negative CML|Ph Negative Chronic Myelogenous Leukemia|Ph' Chromosome Negative Chronic Granulocytic Leukemia|Ph' Chromosome Negative Chronic Myelocytic Leukemia|Ph' Chromosome Negative Chronic Myeloid Leukemia|Ph' Negative Chronic Granulocytic Leukemia|Ph- CML|Ph- Chronic Myelogenous Leukemia|Ph1 Chromosome Negative Chronic Myelocytic Leukemia|Ph1 Chromosome Negative Chronic Myelogenous Leukemia|Philadelphia Chromosome Negative CML|Philadelphia Chromosome Negative Chronic Granulocytic Leukemia|Philadelphia Chromosome Negative Chronic Myelocytic Leukemia|Philadelphia Chromosome Negative Chronic Myeloid Leukemia	A chronic myelogenous leukemia which does not express the Philadelphia chromosome abnormality. --2003
C9130	Adult_Rhabdomyosarcoma	Rhabdomyosarcoma	Adult Rhabdomyosarcoma
C9131	Mucinous_Breast_Carcinoma	Breast_Adenocarcinoma|Invasive_Breast_Carcinoma|Mucinous_Adenocarcinoma	Breast Mucinous Carcinoma|Colloid Breast Carcinoma|Colloid Carcinoma of Breast|Colloid Carcinoma of the Breast|Infiltrating Colloid Breast Carcinoma|Infiltrating Mucinous Breast Carcinoma|Invasive Colloid Breast Carcinoma|Invasive Mucinous Breast Carcinoma|Mucinous Carcinoma of Breast|Mucinous Carcinoma of the Breast
C9132	Invasive_Ductal_Breast_Carcinoma_with_Predominant_Intraductal_Component	Invasive_Ductal_Carcinoma_not_Otherwise_Specified	Invasive Ductal Breast Carcinoma with Predominant Intraductal Component|Infiltrating Ductal Breast Carcinoma with Predominant Intraductal Component
C9133	Adenosquamous_Lung_Carcinoma	Adenosquamous_Carcinoma|Non-Small_Cell_Lung_Carcinoma	Adenosquamous Lung Carcinoma|Adenosquamous Cell Lung Carcinoma	An aggressive carcinoma with a poor prognosis characterized by a presence of both malignant squamous cells and glandular cells. (NCI05)
C9134	Papillary_Breast_Carcinoma	Breast_Adenocarcinoma|Papillary_Adenocarcinoma|Papillary_Breast_Neoplasm	Papillary Breast Carcinoma|Papillary Carcinoma of Breast|Papillary Carcinoma of the Breast	A malignant breast neoplasm characterized by the formation of irregular, finger-like projections of fibrous stroma covered with neoplastic epithelial cells.
C9135	Tubular_Breast_Carcinoma	Breast_Adenocarcinoma|Invasive_Breast_Carcinoma|Tubular_Adenocarcinoma	Tubular Breast Carcinoma|Infiltrating Tubular Breast Carcinoma|Infiltrating Tubular Carcinoma of Breast|Infiltrating Tubular Carcinoma of the Breast|Invasive Tubular Breast Carcinoma|Invasive Tubular Carcinoma of Breast|Invasive Tubular Carcinoma of the Breast|Tubular Carcinoma of Breast|Tubular Carcinoma of the Breast
C9136	Invasive_Lobular_Breast_Carcinoma_with_Predominant_In_Situ_Component	Invasive_Lobular_Breast_Carcinoma	Invasive Lobular Breast Carcinoma with Predominant In Situ Component|Infiltrating Lobular Breast Carcinoma with Predominant In Situ Component
C9137	Combined_Type_Small_Cell_Lung_Carcinoma	Combined_Lung_Carcinoma|Small_Cell_Lung_Carcinoma	Combined Small Cell Lung Carcinoma|Combined Small Cell Carcinoma of Lung|Combined Small Cell Carcinoma of the Lung|Combined Small Cell and Large Cell Lung Carcinoma|Combined Small and Large Cell Lung Cancer|Combined Small and Large Cell Lung Carcinoma|Combined Type Small Cell Carcinoma of Lung|Combined Type Small Cell Carcinoma of the Lung|Combined Type Small Cell Lung Carcinoma|Mixed Small Cell and Large Cell Carcinoma of Lung|Mixed Small Cell and Large Cell Carcinoma of the Lung|Mixed Small Cell and Large Cell Lung Carcinoma|Small Cell and Large Cell Carcinoma of Lung|Small Cell and Large Cell Carcinoma of the Lung|Small Cell and Large Cell Lung Carcinoma	A morphologic variant of small cell lung carcinoma in combination with a non-small cell carcinoma. (NCI05)
C9140	Childhood_Precursor_B_Lymphoblastic_Leukemia	Childhood_Acute_Lymphoblastic_Leukemia|Precursor_B_Lymphoblastic_Leukemia	Childhood Precursor B-Lymphoblastic Leukemia|B Cell Childhood ALL|B Cell Childhood Acute Lymphoblastic Leukemia|B Cell Childhood Acute Lymphocytic Leukemia|B Cell Pediatric ALL|B Cell Pediatric Acute Lymphoblastic Leukemia|B Cell Pediatric Acute Lymphocytic Leukemia|B-Cell Childhood ALL|B-Cell Childhood Acute Lymphoblastic Leukemia|B-Cell Childhood Acute Lymphocytic Leukemia|B-Cell Childhood Acute Lymphogenous Leukemia|B-Cell Childhood Acute Lymphoid Leukemia|B-Cell Pediatric ALL|B-Cell Pediatric Acute Lymphoblastic Leukemia|B-Cell Pediatric Acute Lymphocytic Leukemia|B-Cell Pediatric Acute Lymphogenous Leukemia|B-Cell Pediatric Acute Lymphoid Leukemia
C9141	Non-T_Non-B_cALLa_Positive_Childhood_Acute_Lymphoblastic_Leukemia	cALLa_Positive_Lymphoblastic_Leukemia	Non-T Non-B cALLa Positive Childhood Acute Lymphoblastic Leukemia
C9142	Adult_Precursor_T_Lymphoblastic_Leukemia	Adult_Acute_Lymphoblastic_Leukemia|Precursor_T_Lymphoblastic_Leukemia	Adult Precursor T-Lymphoblastic Leukemia|T Cell Adult ALL|T-Cell Adult ALL|T-Cell Adult Acute Lymphocytic Leukemia
C9143	Adult_Precursor_B_Lymphoblastic_Leukemia	Adult_Acute_Lymphoblastic_Leukemia|Precursor_B_Lymphoblastic_Leukemia	Adult Precursor B-Lymphoblastic Leukemia|Adult B Cell ALL|Adult B Cell Acute Lymphoblastic Leukemia|Adult B Cell Acute Lymphocytic Leukemia|Adult B-Cell ALL|Adult B-Cell Acute Lymphoblastic Leukemia|Adult B-Cell Acute Lymphocytic Leukemia|B Cell Adult ALL|B Cell Adult Acute Lymphoblastic Leukemia|B Cell Adult Acute Lymphocytic Leukemia|B-Cell Adult ALL|B-Cell Adult Acute Lymphoblastic Leukemia|B-Cell Adult Acute Lymphocytic Leukemia
C9144	Non-T_Non-B_cALLa_Positive_Adult_Acute_Lymphoblastic_Leukemia	cALLa_Positive_Lymphoblastic_Leukemia	Non-T Non-B cALLa Positive Adult Acute Lymphoblastic Leukemia
C9145	Osteosarcoma	Infrequent_Neoplasm|Osteogenic_Neoplasm|Sarcoma_of_the_Soft_Tissue_and_Bone	Osteosarcoma|Osteogenic Sarcoma|osteogenic sarcoma|osteosarcoma	(AHS-tee-o-sar-KO-ma) A cancer of the bone that usually affects the large bones of the arm or leg. It occurs most commonly in young people and affects more males than females.
C9146	Epithelial_Predominant_Wilms_Tumor	Renal_Wilms_Tumor	Epithelial Predominant Renal Wilms' Tumor|Epithelial Predominant Kidney Adenosarcoma|Epithelial Predominant Nephroblastoma|Epithelial Predominant Renal Adenosarcoma|Epithelial Predominant Renal Wilm's Tumor|Epithelial Predominant Renal Wilms Tumor
C9147	Blastema_Predominant_Wilms_Tumor	Renal_Wilms_Tumor	Blastema Predominant Renal Wilms' Tumor|Blastema Predominant Kidney Adenosarcoma|Blastema Predominant Nephroblastoma|Blastema Predominant Renal Adenosarcoma|Blastema Predominant Renal Wilm's Tumor|Blastema Predominant Renal Wilms Tumor
C9148	Stromal_Predominant_Wilms_Tumor	Renal_Wilms_Tumor	Stromal Predominant Renal Wilms' Tumor|Stromal Predominant Kidney Adenosarcoma|Stromal Predominant Nephroblastoma|Stromal Predominant Renal Adenosarcoma|Stromal Predominant Renal Wilm's Tumor|Stromal Predominant Renal Wilms Tumor
C9149	Mixed_Cell_Type_Wilms_Tumor	Renal_Wilms_Tumor	Mixed Cell Type Renal Wilms' Tumor|Mixed Cell Type Kidney Adenosarcoma|Mixed Cell Type Nephroblastoma|Mixed Cell Type Renal Adenosarcoma|Mixed Cell Type Renal Wilm's Tumor|Mixed Cell Type Renal Wilms Tumor
C9150	Botryoid-Type_Embryonal_Rhabdomyosarcoma	Embryonal_Rhabdomyosarcoma	Botryoid-Type Embryonal Rhabdomyosarcoma|Botryoid Sarcoma|Sarcoma Botryoides
C9151	Lentigo_Maligna_Melanoma	Cutaneous_Melanoma	Lentigo Maligna Melanoma|Malignant Lentigo Melanoma	A type of melanoma that usually occurs in elderly people with the median age of 70. These lesions are typically flat with irregular borders and shades of color which run form tan to dark brown. -2002
C9152	Superficial_Spreading_Melanoma_of_the_Skin	Cutaneous_Melanoma	Superficial Spreading Melanoma|Cutaneous Superficial Spreading Melanoma|SSM|Superficial Spreading Malignant Melanoma of Skin|Superficial Spreading Malignant Melanoma of the Skin|Superficial Spreading Malignant Skin Melanoma|Superficial Spreading Melanoma of Skin|Superficial Spreading Melanoma of the Skin	A type of melanoma that typically occurs in light-skinned individuals ranging in age from young adults to the elderly.  Risk factors include extensive sun exposure during childhood, a family history of melanoma, and the presence of dysplastic nevi. -- 2003
C9153	Adult_Acute_Erythroid_Leukemia	Acute_Erythroid_Leukemia	Adult Acute Erythroid Leukemia|Adult Acute M6 Leukemia
C9154	Adult_Acute_Myeloid_Leukemia	Acute_Myeloid_Leukemia	Adult Acute Myeloid Leukemia|Adult AGL|Adult AML|Adult ANLL|Adult Acute Granulocytic Leukemia|Adult Acute Myeloblastic Leukemia|Adult Acute Myelocytic Leukemia|Adult Acute Myelogenous Leukemia|Adult Acute Non-Lymphoblastic Leukemia|Adult Acute Non-Lymphocytic Leukemia|Adult Acute NonLymphoblastic Leukemia|Adult Acute NonLymphocytic Leukemia
C9155	Adult_Acute_Promyelocytic_Leukemia	Acute_Promyelocytic_Leukemia|Adult_Acute_Myeloid_Leukemia	Adult Acute Promyelocytic Leukemia|Adult APL|Adult Acute M3 Leukemia|Adult Acute Promyelocytic Leukemia (M3)|M3 Adult Acute Leukemia|M3 Adult Acute Promyelocytic Leukemia
C9156	Adult_Acute_Poorly_Differentiated_Monoblastic_Leukemia	Acute_Monoblastic_Leukemia|Adult_Acute_Monoblastic_Leukemia_and_Acute_Monocytic_Leukemia	Adult Acute Monoblastic Leukemia|Adult Acute M5a Leukemia|M5a Adult Acute Leukemia|M5a Adult Acute Poorly Differentiated Monoblastic Leukemia
C9157	Gastric_Intestinal_Type_Adenocarcinoma	Intestinal_Type_Adenocarcinoma|Sporadic_Gastric_Carcinoma	Gastric Intestinal Type Adenocarcinoma|Intestinal Adenocarcinoma of Stomach|Intestinal Adenocarcinoma of the Stomach|Intestinal Gastric Adenocarcinoma|Intestinal Stomach Adenocarcinoma	Intestinal adenocarcinomas of the stomach closely resemble colonic adenocarcinomas.  Grossly, they tend to be nodular, polypoid or ulcerated.  Microscopically, they have a glandular pattern. --2002
C9158	Childhood_Acute_Myeloid_Leukemia_without_Maturation	Acute_Myeloid_Leukemia_without_Maturation|Childhood_Acute_Myeloid_Leukemia	Childhood Acute Myeloid Leukemia without Maturation|Childhood AML without Maturation|Childhood Acute M1 Leukemia|Childhood Acute Myeloblastic Leukemia Without Maturation (M1)|Childhood Acute Myeloblastic Leukemia without Maturation|Childhood Acute Myelocytic Leukemia without Maturation|Childhood Acute Myelogenous Leukemia without Maturation|M1 Childhood Acute Myeloblastic Leukemia without Maturation|M1 Childhood Acute Myelocytic Leukemia without Maturation|M1 Childhood Acute Myelogenous Leukemia without Maturation|M1 Childhood Acute Myeloid Leukemia without Maturation|M1 Pediatric Acute Myeloblastic Leukemia without Maturation|M1 Pediatric Acute Myelocytic Leukemia without Maturation|M1 Pediatric Acute Myelogenous Leukemia|M1 Pediatric Acute Myelogenous Leukemia without Maturation|M1 Pediatric Acute Myeloid Leukemia without Maturation|Pediatric AML without Maturation|Pediatric Acute M1 Leukemia|Pediatric Acute Myeloblastic Leukemia without Maturation|Pediatric Acute Myelocytic Leukemia without Maturation|Pediatric Acute Myelogenous Leukemia without Maturation|Pediatric Acute Myeloid Leukemia without Maturation
C9159	Diffuse_Gastric_Adenocarcinoma	Diffuse_Type_Adenocarcinoma|Signet_Ring_Cell_Gastric_Adenocarcinoma	Diffuse Gastric Adenocarcinoma|Adenocarcinoma of Linitis Plastica Type|Adenocarcinoma of the Linitis Plastica Type|Diffuse Adenocarcinoma of Stomach|Diffuse Adenocarcinoma of the Stomach|Diffuse Stomach Adenocarcinoma	Diffuse adenocarcinomas of the stomach have a plaque-like surface component.  Microscopically, there is a diffuse infiltrate, composed of individual cells or groups of cells in a fibrous or mucoid stroma.  Many cells contain mucin droplets, producing a signet-ring configuration. --2002
C9160	Childhood_Acute_Myeloid_Leukemia	Acute_Myeloid_Leukemia|Childhood_Leukemia	Childhood Acute Myeloid Leukemia|Childhood AML|Childhood Acute Granulocytic Leukemia|Childhood Acute Myeloblastic Leukemia|Childhood Acute Myelocytic Leukemia|Childhood Acute Myelogenous Leukemia|Pediatric AML|Pediatric Acute Myeloblastic Leukemia|Pediatric Acute Myelocytic Leukemia|Pediatric Acute Myelogenous Leukemia|Pediatric Acute Myeloid Leukemia	Acute myeloid leukemia occuring in childhood.
C9161	Anal_Squamous_Cell_Carcinoma	Anal_Carcinoma|Squamous_Cell_Carcinoma	Anal Squamous Cell Carcinoma|Epidermoid Anal Carcinoma|Epidermoid Carcinoma of Anus|Epidermoid Carcinoma of the Anus|Squamous Cell Anal Carcinoma|Squamous Cell Carcinoma of Anus|Squamous Cell Carcinoma of the Anus	A squamous cell carcinoma (SCC) arising in the anal canal or the anal margin (perianal skin).  The distinction between anal canal and anal margin SCC may be difficult, as tumors often involve both areas at the time of diagnosis.  The prognosis is generally better for anal margin SCC than for anal canal SCC.  -- 2003
C9162	Childhood_Acute_Monoblastic_Leukemia_without_Differentiation	Acute_Monoblastic_Leukemia|Childhood_Acute_Monoblastic_Leukemia_and_Acute_Monocytic_Leukemia	Childhood Acute Monoblastic Leukemia|Childhood Acute M5a Leukemia|Childhood Acute Monoblastic Leukemia without Differentiation|M5a Childhood Acute Monoblastic Leukemia without Differentiation|M5a Pediatric Acute Monoblastic Leukemia without Differentiation|Pediatric Acute M5a Leukemia|Pediatric Acute Monoblastic Leukemia without Differentiation
C9163	Childhood_Acute_Differentiated_Monocytic_Leukemia	Childhood_Acute_Monoblastic_Leukemia_and_Acute_Monocytic_Leukemia|Monocytic_Leukemia	Childhood Acute Monocytic Leukemia|Childhood Acute Differentiated Monocytic Leukemia (M5b)|Childhood Acute M5b Leukemia|Childhood Acute Monocytic Leukemia with Differentiation|M5b Childhood Acute Differentiated Monocytic Leukemia|M5b Pediatric Acute Differentiated Monocytic Leukemia|Pediatric Acute Differentiated Monocytic Leukemia|Pediatric Acute M5b Leukemia|Pediatric Acute Monocytic Leukemia with Differentiation
C9164	Childhood_Acute_Erythroid_Leukemia	Acute_Erythroid_Leukemia	Childhood Acute Erythroid Leukemia|Childhood M6 Leukemia|Pediatric Acute Erythroid Leukemia|Pediatric M6 Leukemia
C9165	Childhood_Acute_Eosinophilic_Leukemia	Acute_Eosinophilic_Leukemia|Childhood_Acute_Myeloid_Leukemia	Childhood Acute Eosinophilic Leukemia|Pediatric Acute Eosinophilic Leukemia
C9166	Gallbladder_Adenocarcinoma	Adenocarcinoma|Gallbladder_Carcinoma	Gallbladder Adenocarcinoma|Adenocarcinoma of Gallbladder|Adenocarcinoma of the Gallbladder
C9167	Undifferentiated_Gallbladder_Carcinoma	Gallbladder_Carcinoma|Undifferentiated_Carcinoma	Undifferentiated Gallbladder Carcinoma|Anaplastic Carcinoma of Gallbladder|Anaplastic Carcinoma of the Gallbladder|Anaplastic Gallbladder Carcinoma|Undifferentiated Carcinoma of Gallbladder|Undifferentiated Carcinoma of the Gallbladder
C9168	Rectal_Signet_Ring_Cell_Adenocarcinoma	Colorectal_Signet_Ring_Cell_Carcinoma|Rectal_Adenocarcinoma	Rectal Signet Ring Cell Adenocarcinoma|Signet Ring Adenocarcinoma of Rectum|Signet Ring Adenocarcinoma of the Rectum|Signet Ring Cell Adenocarcinoma of Rectum|Signet Ring Cell Adenocarcinoma of the Rectum
C9169	Gallbladder_Adenocarcinoma_with_Squamous_Metaplasia	Adenocarcinoma_with_Squamous_Metaplasia|Gallbladder_Adenocarcinoma	Gallbladder Adenocarcinoma with Squamous Metaplasia|Adenocarcinoma of Gallbladder with Squamous Metaplasia|Adenocarcinoma of the Gallbladder with Squamous Metaplasia
C9170	Gallbladder_Squamous_Cell_Carcinoma	Gallbladder_Carcinoma|Squamous_Cell_Carcinoma	Gallbladder Squamous Cell Carcinoma|Epidermoid Carcinoma of Gallbladder|Epidermoid Carcinoma of the Gallbladder|Epidermoid Gallbladder Carcinoma|Squamous Cell Carcinoma of Gallbladder|Squamous Cell Carcinoma of the Gallbladder|Squamous Cell Gallbladder Carcinoma
C9172	Mixed_Embryonal_Carcinoma_and_Yolk_Sac_Neoplasm_with_Seminoma_of_the_Testis	Testicular_Mixed_Germ_Cell_Neoplasm	Testicular Mixed Embryonal Carcinoma and Yolk Sac Tumor with Seminoma|Mixed Embryonal Carcinoma and Endodermal Sinus Neoplasm with Seminoma of Testis|Mixed Embryonal Carcinoma and Endodermal Sinus Neoplasm with Seminoma of the Testis|Mixed Embryonal Carcinoma and Endodermal Sinus Tumor with Seminoma of Testis|Mixed Embryonal Carcinoma and Endodermal Sinus Tumor with Seminoma of the Testis|Mixed Embryonal Carcinoma and Yolk Sac Neoplasm with Seminoma of Testis|Mixed Embryonal Carcinoma and Yolk Sac Neoplasm with Seminoma of the Testis|Mixed Embryonal Carcinoma and Yolk Sac Tumor with Seminoma of Testis|Mixed Embryonal Carcinoma and Yolk Sac Tumor with Seminoma of the Testis|Testicular Mixed Embryonal Carcinoma and Endodermal Sinus Tumor with Seminoma|Testicular Mixed Embryonal Carcinoma and Yolk Sac Neoplasm with Seminoma
C9173	Testicular_Mixed_Choriocarcinoma_and_Seminoma	Testicular_Mixed_Germ_Cell_Neoplasm	Testicular Mixed Choriocarcinoma and Seminoma|Mixed Choriocarcinoma and Seminoma of Testis|Mixed Choriocarcinoma and Seminoma of the Testis
C9174	Childhood_Angiosarcoma	Angiosarcoma	Childhood Angiosarcoma|Childhood Hemangiosarcoma|Pediatric Angiosarcoma|Pediatric Hemangiosarcoma
C9175	Bowel_Obstruction	Intestinal_Disorder	Bowel Obstruction
C9176	Non-Metastatic_Gestational_Trophoblastic_Tumor	Gestational_Trophoblastic_Tumor|Non-Metastatic_Neoplasm	Non-Metastatic Gestational Trophoblastic Tumor|Non-Metastatic GTT|Non-Metastatic Gestational Trophoblastic Neoplasm|Nonmetastatic Gestational Trophoblastic Tumor
C9177	Good_Prognosis_Metastatic_Gestational_Trophoblastic_Tumor	Gestational_Trophoblastic_Tumor	Good Prognosis Metastatic Gestational Trophoblastic Tumor
C9178	Poor_Prognosis_Metastatic_Gestational_Trophoblastic_Tumor	Gestational_Trophoblastic_Tumor	Poor Prognosis Metastatic Gestational Trophoblastic Tumor
C9179	Stage_IV_Uterine_Sarcoma	Uterine_Corpus_Sarcoma	Stage IV Uterine Sarcoma
C9180	Uterine_Corpus_Malignant_Mixed_Mesodermal_Mullerian_Tumor	Malignant_Uterine_Corpus_Mixed_Neoplasm|Uterine_Carcinosarcoma	Uterine Corpus Carcinosarcoma|Carcinosarcoma of Corpus Uteri|Carcinosarcoma of Uterine Body|Carcinosarcoma of Uterine Corpus|Carcinosarcoma of Uterus|Carcinosarcoma of the Corpus Uteri|Carcinosarcoma of the Uterine Body|Carcinosarcoma of the Uterine Corpus|Carcinosarcoma of the Uterus|Corpus Uteri Malignant Mixed Mesodermal Tumor|Malignant Mixed Mesodermal Neoplasm of Uterine Body|Malignant Mixed Mesodermal Neoplasm of Uterine Corpus|Malignant Mixed Mesodermal Neoplasm of Uterus|Malignant Mixed Mesodermal Neoplasm of the Uterine Body|Malignant Mixed Mesodermal Neoplasm of the Uterine Corpus|Malignant Mixed Mesodermal Neoplasm of the Uterus|Malignant Mixed Mesodermal Tumor of Uterine Body|Malignant Mixed Mesodermal Tumor of Uterine Corpus|Malignant Mixed Mesodermal Tumor of Uterus|Malignant Mixed Mesodermal Tumor of the Uterine Body|Malignant Mixed Mesodermal Tumor of the Uterine Corpus|Malignant Mixed Mesodermal Tumor of the Uterus|Mixed Mullerian Sarcoma of Uterus|Mixed Mullerian Sarcoma of the Uterus|Uterine Body Carcinosarcoma|Uterine Body Malignant Mixed Mesodermal Neoplasm|Uterine Body Malignant Mixed Mesodermal Tumor|Uterine Carcinosarcoma|Uterine Corpus Malignant Mixed Mesodermal (Mullerian) Tumor|Uterine Corpus Malignant Mixed Mesodermal Neoplasm|Uterine Corpus Malignant Mixed Mesodermal Tumor|Uterine Corpus Malignant Mixed Mullerian Neoplasm|Uterine Corpus Malignant Mixed Mullerian Tumor|Uterine Malignant Mixed Mesodermal Neoplasm|Uterine Malignant Mixed Mesodermal Tumor|Uterine Mixed Mullerian Sarcoma	A rare malignancy of mixed histological type involving endometrial adenocarcinoma and sarcomatous cells. Uterine carcinosarcoma is associated with prior radiation therapy as a risk factor. While hysterosalpingo-oophorectomy is usually performed in an attempt to contain the disease, further clinical trials will need to be done to optimize the chemotherapy and/or radiation therapy regimen for these patients.
C9181	Recurrent_Carcinoma_of_Unknown_Primary	Carcinoma_of_Unknown_Primary|Recurrent_Carcinoma	Recurrent Carcinoma of Unknown Primary
C9182	Deep_Fibromatosis_Desmoid_Tumor	Common_Connective_and_Soft_Tissue_Neoplasm|Fibromatosis	Deep Fibromatosis/Desmoid Tumor|Deep Fibromatosis|Desmoid Fibromatosis|Desmoid Tumor|Desmoid-Type Fibromatosis|desmoid tumor	A tumor of the tissue that surrounds muscles, usually in the abdomen. A desmoid tumor rarely metastasizes (spreads to other parts of the body).  Also called aggressive fibromatosis, especially when the tumor is outside the abdomen.
C9183	Malignant_Adult_Intracranial_Hemangiopericytoma	Adult_Intracranial_Neoplasm|Adult_Soft_Tissue_Sarcoma|Malignant_Adult_Hemangiopericytoma|Malignant_Central_Nervous_System_Soft_Tissue_Neoplasm	Malignant Adult Intracranial Hemangiopericytoma|Adult Intracranial Malignant Hemangiopericytoma|Adult Malignant Intracranial Hemangiopericytoma
C9184	Intraocular_Lymphoma	Eye_Lymphoma	Intraocular Lymphoma|Primary Intraocular Lymphoma
C9185	Stage_I_Childhood_Burkitt_s_Lymphoma	Childhood_Burkitt_s_Lymphoma|Stage_I_Burkitt_s_Lymphoma	Stage I Childhood Burkitt's Lymphoma|Childhood Small Non-Cleaved Cell Lymphoma Stage I|Pediatric Small Non-Cleaved Cell Lymphoma Stage I|Stage I Childhood Small Non-Cleaved Cell Lymphoma|Stage I Pediatric Small Non-Cleaved Cell Lymphoma
C9186	Stage_II_Childhood_Burkitt_s_Lymphoma	Childhood_Burkitt_s_Lymphoma|Stage_II_Burkitt_s_Lymphoma	Stage II Childhood Burkitt's Lymphoma|Childhood Small Non-Cleaved Cell Lymphoma Stage II|Pediatric Small Non-Cleaved Cell Lymphoma Stage II|Stage II Childhood Burkitt Lymphoma|Stage II Childhood Small Non-Cleaved Cell Lymphoma|Stage II Pediatric Small Non-Cleaved Cell Lymphoma
C9187	Stage_III_Childhood_Burkitt_s_Lymphoma	Childhood_Burkitt_s_Lymphoma|Stage_III_Burkitt_s_Lymphoma	Stage III Childhood Burkitt's Lymphoma|Childhood Small Non-Cleaved Cell Lymphoma Stage III|Pediatric Small Non-Cleaved Cell Lymphoma Stage III|Stage III Childhood Burkitt Lymphoma|Stage III Childhood Small Non-Cleaved Cell Lymphoma|Stage III Pediatric Small Non-Cleaved Cell Lymphoma
C9188	Stage_IV_Childhood_Burkitt_s_Lymphoma	Childhood_Burkitt_s_Lymphoma|Stage_IV_Burkitt_s_Lymphoma	Stage IV Childhood Burkitt's Lymphoma|Childhood Small Non-Cleaved Cell Lymphoma Stage IV|Metastatic Childhood Small Non-Cleaved Cell Lymphoma|Metastatic Pediatric Small Non-Cleaved Cell Lymphoma|Pediatric Small Non-Cleaved Cell Lymphoma Stage IV|Stage IV Childhood Burkitt Lymphoma|Stage IV Childhood Small Non-Cleaved Cell Lymphoma|Stage IV Pediatric Small Non-Cleaved Cell Lymphoma
C9189	Recurrent_Childhood_Burkitt_s_Lymphoma	Childhood_Burkitt_s_Lymphoma|Recurrent_Burkitt_s_Lymphoma	Recurrent Childhood Burkitt's Lymphoma|Recurrent Childhood Burkitt Lymphoma|Recurrent Childhood Small Non-Cleaved Cell Lymphoma|Recurrent Pediatric Small Non-Cleaved Cell Lymphoma|Relapsed Childhood Small Non-Cleaved Cell Lymphoma|Relapsed Pediatric Small Non-Cleaved Cell Lymphoma
C9190	Recurrent_Childhood_Brain_Stem_Glioma	Childhood_Brain_Stem_Glioma|Recurrent_Childhood_Brain_Neoplasm	Recurrent Childhood Brain Stem Glioma|Recurrent Childhood Brainstem Glioma|Recurrent Childhood Glioma of Brain Stem|Recurrent Childhood Glioma of Brainstem|Recurrent Childhood Glioma of the Brain Stem|Recurrent Childhood Glioma of the Brainstem|Recurrent Pediatric Brain Stem Glioma|Recurrent Pediatric Brainstem Glioma|Recurrent Pediatric Glioma of Brain Stem|Recurrent Pediatric Glioma of Brainstem|Recurrent Pediatric Glioma of the Brain Stem|Recurrent Pediatric Glioma of the Brainstem|Relapsed Childhood Brain Stem Glioma|Relapsed Childhood Brainstem Glioma|Relapsed Childhood Glioma of Brain Stem|Relapsed Childhood Glioma of Brainstem|Relapsed Childhood Glioma of the Brain Stem|Relapsed Childhood Glioma of the Brainstem|Relapsed Pediatric Brain Stem Glioma|Relapsed Pediatric Brainstem Glioma|Relapsed Pediatric Glioma of Brain Stem|Relapsed Pediatric Glioma of Brainstem|Relapsed Pediatric Glioma of the Brain Stem|Relapsed Pediatric Glioma of the Brainstem
C9191	Recurrent_Childhood_Cerebral_Astrocytoma	Childhood_Cerebral_Astrocytoma|Recurrent_Childhood_Brain_Neoplasm	Recurrent Childhood Cerebral Astrocytoma
C9192	Ovarian_Malignant_Mixed_Mesodermal_Mullerian_Tumor	Malignant_Mixed_Mesodermal_Mullerian_Tumor|Malignant_Ovarian_Endometrioid_Tumor	Ovarian Carcinosarcoma|Carcinosarcoma of Ovary|Carcinosarcoma of the Ovary|Malignant Mixed Mesodermal Mullerian Neoplasm of Ovary|Malignant Mixed Mesodermal Mullerian Neoplasm of the Ovary|Malignant Mixed Mesodermal Mullerian Tumor of Ovary|Malignant Mixed Mesodermal Mullerian Tumor of the Ovary|Ovarian MMMT|Ovarian Malignant Mesodermal (Mullerian) Mixed Tumor|Ovarian Malignant Mixed Mesodermal (Mullerian) Tumor|Ovarian Malignant Mixed Mesodermal Mullerian Neoplasm|Ovarian Malignant Mixed Mesodermal Mullerian Tumor|Ovarian Malignant Mixed Mullerian Neoplasm|Ovarian Malignant Mixed Mullerian Tumor
C9193	Stage_II_Contiguous_Adult_Burkitt_s_Lymphoma	Stage_II_Adult_Burkitt_s_Lymphoma|Stage_II_Contiguous_Adult_Non-Hodgkin_s_Lymphoma	Stage II Contiguous Adult Burkitt's Lymphoma|Contiguous Adult Diffuse Small Non-Cleaved Cell Lymphoma Stage II|Contiguous Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma Stage II|Contiguous Stage II Adult Diffuse Small Non-Cleaved Cell Lymphoma|Stage II Contiguous Adult Burkitt Lymphoma|Stage II Contiguous Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma
C9194	Stage_II_Grade_1_Non-Contiguous_Follicular_Lymphoma	Stage_II_Grade_1_Follicular_Lymphoma	Stage II Grade 1 Non-Contiguous Follicular Lymphoma|Non-Contiguous Follicular Small Cleaved Cell Lymphoma Stage II|Non-Contiguous Grade I Follicular Lymphoma Stage II|Non-Contiguous Grade I Follicular Small Cleaved Cell Lymphoma Stage II|Non-Contiguous Stage II Follicular Small Cleaved Cell Lymphoma|Non-Contiguous Stage II Grade I Follicular Lymphoma|Non-Contiguous Stage II Grade I Follicular Small Cleaved Cell Lymphoma|Stage II Non-Contiguous Follicular Small Cleaved Cell Lymphoma
C9195	Stage_II_Grade_2_Non-Contiguous_Follicular_Lymphoma	Stage_II_Grade_2_Follicular_Lymphoma	Stage II Grade 2 Non-Contiguous Follicular Lymphoma|Non-Contiguous Follicular Mixed Cell Lymphoma Stage II|Non-Contiguous Grade II Follicular Lymphoma Stage II|Non-Contiguous Grade II Follicular Mixed Cell Lymphoma Stage II|Non-Contiguous Stage II Follicular Mixed Cell Lymphoma|Non-Contiguous Stage II Grade II Follicular Lymphoma|Non-Contiguous Stage II Grade II Follicular Mixed Cell Lymphoma|Stage II Non-Contiguous Follicular Mixed Cell Lymphoma
C9196	Stage_II_Grade_3_Non-Contiguous_Follicular_Lymphoma	Stage_II_Grade_3_Follicular_Lymphoma	Stage II Grade 3 Non-Contiguous Follicular Lymphoma|Non-Contiguous Follicular Large Cell Lymphoma Stage II|Non-Contiguous Grade III Follicular Large Cell Lymphoma Stage II|Non-Contiguous Grade III Follicular Lymphoma Stage II|Non-Contiguous Stage II Follicular Large Cell Lymphoma|Non-Contiguous Stage II Grade III Follicular Large Cell Lymphoma|Non-Contiguous Stage II Grade III Follicular Lymphoma|Stage II Non-Contiguous Follicular Large Cell Lymphoma
C9197	Stage_II_Non-Contiguous_Adult_Diffuse_Small_Cleaved_Cell_Lymphoma	Stage_II_Adult_Diffuse_Small_Cleaved_Cell_Lymphoma	Stage II Non-Contiguous Adult Diffuse Small Cleaved Cell Lymphoma|Non-Contiguous Adult Diffuse Small Cleaved Cell Lymphoma Stage II|Non-Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma
C9198	Stage_II_Non-Contiguous_Mantle_Cell_Lymphoma	Stage_II_Mantle_Cell_Lymphoma	Stage II Non-Contiguous Mantle Cell Lymphoma|Non-Contiguous Mantle Cell Lymphoma Stage II|Non-Contiguous Stage II Mantle Cell Lymphoma
C9199	Stage_II_Non-Contiguous_Adult_Diffuse_Mixed_Cell_Lymphoma	Stage_II_Adult_Diffuse_Mixed_Cell_Lymphoma	Stage II Non-Contiguous Adult Diffuse Mixed Cell Lymphoma|Non-Contiguous Adult Diffuse Mixed Cell Lymphoma Stage II|Non-Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma
C9200	Stage_II_Non-Contiguous_Adult_Burkitt_s_Lymphoma	Stage_II_Adult_Burkitt_s_Lymphoma|Stage_II_Non-Contiguous_Adult_Non-Hodgkin_s_Lymphoma	Stage II Non-Contiguous Adult Burkitt's Lymphoma|Non-Contiguous Adult Diffuse Small Non-Cleaved Cell Lymphoma Stage II|Non-Contiguous Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma Stage II|Stage II Non-Contiguous Adult Burkitt Lymphoma|Stage II Non-Contiguous Adult Diffuse Small Non-Cleaved Cell Lymphoma|Stage II Non-Contiguous Adult Diffuse Small Non-Cleaved Cell/Burkitt's Lymphoma
C9201	Angioimmunoblastic_Lymphadenopathy_with_Dysproteinemia	Angioimmunoblastic_Lymphadenopathy	Angioimmunoblastic Lymphadenopathy with Dysproteinemia
C9202	Stage_II_Mantle_Cell_Lymphoma	Mantle_Cell_Lymphoma|Stage_II_B-Cell_Non-Hodgkin_s_Lymphoma	Stage II Mantle Cell Lymphoma|Mantle Cell Lymphoma Stage II	Ann Arbor Classification: Stage II: Involvement of two or more lymph node regions on the same side of the diaphragm (II); or localized involvement of a single extralymphatic organ or site in association with regional lymph node involvement with or without involvement of other lymph node regions on the same side of the diaphragm (IIE). - 2003
C9203	Breakthrough_Pain	Pain	Breakthrough Pain|breakthrough pain	Intense increases in pain that occur with rapid onset even when pain-control medication is being used.  Breakthrough pain can occur spontaneously or in relation to a specific activity.
C9204	Stage_I_Cervical_Cancer	Cervical_Carcinoma	Stage I Cervical Cancer|AJCC Stage I Cervical Cancer|Cervical Cancer Stage I|Cervical Carcinoma Stage I|FIGO Stage I Carcinoma of Cervix|FIGO Stage I Carcinoma of Cervix Uteri|FIGO Stage I Carcinoma of Uterine Cervix|FIGO Stage I Carcinoma of the Cervix|FIGO Stage I Carcinoma of the Cervix Uteri|FIGO Stage I Carcinoma of the Uterine Cervix|FIGO Stage I Cervical Carcinoma|FIGO Stage I Cervix Carcinoma|FIGO Stage I Cervix Uteri Carcinoma|FIGO Stage I Uterine Cervix Carcinoma|Uterine Cervix Cancer Stage I|stage I cancer of the cervix	Cancer that involves the cervix but has not spread to nearby tissues. In stage IA cancer of the cervix, a very small amount of cancer that is only visible under a microscope is found deeper in the tissues of the cervix. In stage IB cancer, a larger amount of cancer is found in the tissues of the cervix.
C9205	Stage_III_Cervical_Cancer	Cervical_Carcinoma	Stage III Cervical Cancer|AJCC Stage III Cervical Cancer|Cervical Cancer Stage III|Cervical Carcinoma Stage III|FIGO Stage III Carcinoma of Cervix|FIGO Stage III Carcinoma of Cervix Uteri|FIGO Stage III Carcinoma of Uterine Cervix|FIGO Stage III Carcinoma of the Cervix|FIGO Stage III Carcinoma of the Cervix Uteri|FIGO Stage III Carcinoma of the Uterine Cervix|FIGO Stage III Cervical Carcinoma|FIGO Stage III Cervix Carcinoma|FIGO Stage III Cervix Uteri Carcinoma|FIGO Stage III Uterine Cervix Carcinoma|stage III cancer of the cervix	Cancer has spread throughout the pelvic area, and cancer cells may have spread to the lower part of the vagina. The cells also may have spread to block the tubes that connect the kidneys to the bladder (the ureters).
C9206	Stage_IV_Cervical_Cancer	Cervical_Carcinoma	Stage IV Cervical Cancer|AJCC Stage IV Cervical Cancer|Cervical Cancer Stage IV|Cervical Carcinoma Stage IV|FIGO Stage IV Carcinoma of Cervix|FIGO Stage IV Carcinoma of Cervix Uteri|FIGO Stage IV Carcinoma of Uterine Cervix|FIGO Stage IV Carcinoma of the Cervix|FIGO Stage IV Carcinoma of the Cervix Uteri|FIGO Stage IV Carcinoma of the Uterine Cervix|FIGO Stage IV Cervical Carcinoma|FIGO Stage IV Cervix Carcinoma|FIGO Stage IV Cervix Uteri Carcinoma|FIGO Stage IV Uterine Cervix Carcinoma|stage IV cancer of the cervix	Cancer has spread to other parts of the body. In stage IVA cancer of the cervix, cancer has spread to the bladder or rectum (organs close to the cervix); in stage IVB cancer of the cervix, cancer has spread to distant organs such as the lungs.
C9207	Stage_I_Endometrial_Cancer	Endometrial_Carcinoma	Stage I Endometrial Cancer|Stage I Cancer of Uterus|Stage I Cancer of the Uterus|Stage I Endometrial Carcinoma|stage I cancer of the uterus|stage I endometrial cancer	Stage I includes: I (T1, N0, M0); IA: (T1a, N0, M0); IB (T1b, N0, M0); IC (T1c, N0, M0).  T1: Tumor confined to corpus uteri. T1a: Tumor limited to the endometrium.  T1b: Tumor invades less than one-half of the myometrium.  T1c: Tumor invades one-half or more of the myometrium.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C9208	Stage_II_Endometrial_Cancer	Endometrial_Carcinoma	Stage II Endometrial Cancer|Stage II Cancer of Uterus|Stage II Cancer of the Uterus|Stage II Endometrial Carcinoma|stage II cancer of the uterus|stage II endometrial cancer	Cancer that has spread to the cervix.
C9209	Stage_III_Endometrial_Cancer	Endometrial_Carcinoma	Stage III Endometrial Cancer|Stage III Cancer of Uterus|Stage III Cancer of the Uterus|Stage III Endometrial Carcinoma|stage III cancer of the uterus|stage III endometrial cancer	Cancer cells have spread outside the uterus to the vagina and/or lymph nodes in the pelvis but have not spread outside the pelvis.
C9210	Stage_I_Esophageal_Cancer	Esophageal_Carcinoma	Stage I Esophageal Cancer|Esophageal Cancer Stage I|Stage I Carcinoma of Esophagus|Stage I Carcinoma of the Esophagus|Stage I Esophageal Carcinoma|Stage I Esophagus Carcinoma|stage I cancer of the esophagus	Cancer that is found in the lining of the esophagus but has not spread to nearby tissues, lymph nodes, or other organs.
C9211	Stage_II_Esophageal_Cancer	Esophageal_Carcinoma	Stage II Esophageal Cancer|Esophageal Cancer Stage II|Stage II Carcinoma of Esophagus|Stage II Carcinoma of the Esophagus|Stage II Esophageal Carcinoma|Stage II Esophagus Carcinoma|stage II cancer of the esophagus	Cancer that may be found in all layers of esophageal tissue and may have spread to regional lymph nodes, but has not spread to other tissues.
C9212	Stage_III_Esophageal_Cancer	Esophageal_Carcinoma	Stage III Esophageal Cancer|Esophageal Cancer Stage III|Stage III Carcinoma of Esophagus|Stage III Carcinoma of the Esophagus|Stage III Esophageal Carcinoma|Stage III Esophagus Carcinoma|stage III cancer of the esophagus	Cancer has spread to tissues or lymph nodes near the esophagus but has not spread to other parts of the body.
C9213	Stage_IV_Esophageal_Cancer	Esophageal_Carcinoma	Stage IV Esophageal Cancer|Metastatic Carcinoma of Esophagus|Metastatic Carcinoma of the Esophagus|Metastatic Esophageal Carcinoma|Stage IV Carcinoma of Esophagus|Stage IV Carcinoma of the Esophagus|Stage IV Esophageal Carcinoma|Stage IV Esophagus Carcinoma|stage IV cancer of the esophagus	Cancer has spread to lymph nodes and other parts of the body far from the esophagus.
C9214	Stage_I_Adrenal_Cortex_Carcinoma	Adrenal_Cortex_Carcinoma	Stage I Adrenal Cortex Carcinoma|Stage I Adrenocortical Carcinoma|Stage I Carcinoma of Adrenal Cortex|Stage I Carcinoma of the Adrenal Cortex|stage I adrenocortical cancer	Cancer that is smaller than 5 centimeters (smaller than 2 inches) and has not spread into tissues around the adrenal gland.
C9215	Stage_II_Adrenal_Cortex_Carcinoma	Adrenal_Cortex_Carcinoma	Stage II Adrenal Cortex Carcinoma|Stage II Adrenocortical Carcinoma|Stage II Carcinoma of Adrenal Cortex|Stage II Carcinoma of the Adrenal Cortex|stage II adrenocortical cancer	Cancer that is larger than 5 centimeters (about 2 inches) and has not spread into tissues around the adrenal gland.
C9216	Stage_III_Adrenal_Cortex_Carcinoma	Adrenal_Cortex_Carcinoma	Stage III Adrenal Cortex Carcinoma|Stage III Adrenocortical Carcinoma|Stage III Carcinoma of Adrenal Cortex|Stage III Carcinoma of the Adrenal Cortex|stage III adrenocortical cancer	The cancer has spread into tissues around the adrenal gland or has spread to the lymph nodes around the adrenal gland.
C9217	Stage_IV_Adrenal_Cortex_Carcinoma	Adrenal_Cortex_Carcinoma	Stage IV Adrenal Cortex Carcinoma|Metastatic Adrenal Cortex Carcinoma|Metastatic Adrenocortical Carcinoma|Metastatic Carcinoma of Adrenal Cortex|Metastatic Carcinoma of the Adrenal Cortex|Stage IV Adrenocortical Carcinoma|Stage IV Carcinoma of Adrenal Cortex|Stage IV Carcinoma of the Adrenal Cortex|stage IV adrenocortical cancer	The cancer has spread to tissues or organs in the area and to lymph nodes around the adrenal cortex, or the cancer has spread to other parts of the body.
C9218	Stage_IV_Oropharyngeal_Carcinoma	Oropharyngeal_Carcinoma	Stage IV Oropharyngeal Carcinoma|Oropharyngeal Cancer Stage IV|Stage IV Carcinoma of Oropharynx|Stage IV Carcinoma of the Oropharynx|Stage IV Oropharyngeal Cancer|Stage IV Oropharynx Carcinoma|stage IV oropharynx cancer	Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (T4a, N2, M0); IVB (T4b, Any N, M0); IVC (Any T, Any N, M1). T4a: Tumor invades the larynx, deep/extrinsic muscle of tongue, medial pterygoid, hard palate, or mandible. T4b: Tumor invades lateral pterygoid muscle, pterygoid plates lateral nasopharynx, or skull base or encases carotid artery. M1: Distant Metastasis. (AJCC 6th ed.) - 2003
C9219	Cancer_Patient_and_Depression_and_Suicide	Funding_Category	Cancer Patient Depression and Suicide
C9220	Stage_III_Renal_Cell_Cancer	Renal_Cell_Carcinoma	Stage III Renal Cell Cancer|Renal Cell Cancer Stage III|Renal Cell Carcinoma, Stage III|Stage III Renal Cell Carcinoma|stage III kidney cancer	Kidney cancer that has spread to the major veins of the kidney and may have spread to a single lymph node.
C9221	Recurrent_Childhood_Malignant_Germ_Cell_Neoplasm	Malignant_Childhood_Germ_Cell_Tumor	Recurrent Childhood Malignant Germ Cell Neoplasm|Recurrent Childhood Malignant Germ Cell Tumor
C9222	Hereditary_Renal_Papillary_Carcinoma	Hereditary_Renal_Cell_Carcinoma|Papillary_Renal_Cell_Carcinoma	Hereditary Papillary Renal Carcinoma|Familial Renal Papillary Carcinoma|Hereditary Kidney Papillary Carcinoma|Hereditary Papillary Carcinoma of Kidney|Hereditary Papillary Carcinoma of the Kidney
C9224	Esophagitis	Esophageal_Disorder|Non-Neoplastic_Gastrointestinal_Disorder	Esophagitis|esophagitis	Inflammation of the esophagus (the tube that carries food from the mouth to the stomach).
C9225	Oral_Complications_of_Chemotherapy_and_Head_and_Neck_Radiation	Oral_Complications_of_Cancer_and_Cancer_Therapy	Oral Complications of Chemotherapy and Head and Neck Radiation
C9226	Non-Hematologic_Malignancy	Malignant_Neoplasm	Non-Hematologic Malignancy|Non-Hematologic Cancer|nonhematologic cancer	Cancer that does not begin in the blood or bone marrow.
C9227	Hypogonadotropism	Non-Neoplastic_Endocrine_Disorder|Non-Neoplastic_Gonadal_Disorder	Hypogonadotropism
C9228	Terminal_Disease	Clinical_Course_of_Disease	Terminal Disease|Terminal Illness|terminal disease	An illness that has a prognosis of death.
C9229	Systemic_Disease	Clinical_Course_of_Disease	Systemic Disease|systemic disease	Disease that affects the whole body.
C9230	Myelosuppression	Abnormal_Bone_Marrow_Test_Result	Myelosuppression|myelosuppression	A condition in which bone marrow activity is decreased, resulting in fewer red blood cells, white blood cells, and platelets.  Myelosuppression is a side effect of some cancer treatments.
C9231	Neuroendocrine_Carcinoma_of_the_Skin	Infrequent_Neoplasm|Neuroendocrine_Carcinoma|Skin_Carcinoma	Neuroendocrine Carcinoma of the Skin|Cutaneous Apudoma|Cutaneous Neuroendocrine Carcinoma|Merkel Cell Carcinoma|Merkel cell cancer|Neuroendocrine Carcinoma of Skin|Neuroendocrine Skin Carcinoma|Trabecular Skin Carcinoma	A rare type of cancer that develops on or just beneath the skin.
C9232	Weight_Change	Symptom	Weight Change
C9233	Juvenile_Myelomonocytic_Leukemia	Myelodysplastic_Myeloproliferative_Disease	Juvenile Myelomonocytic Leukemia|JCML|JMML|Juvenile Chronic Myelogenous Leukemia|Juvenile Chronic Myeloid Leukemia|juvenile myelomonocytic leukemia	A myelodysplastic/myeloproliferative disease of childhood that is characterized by proliferation principally of the granulocytic and monocytic lineages.  Myelomonocytic proliferation is seen in the bone marrow and the blood.  The leukemic cells may infiltrate any tissue, however liver, spleen, lymph nodes, skin, and respiratory tract are the most common sites of involvement.  The prognosis is usually poor.  (WHO, 2001) -- 2003
C9234	Childhood_Spinal_Cord_Neoplasm	Childhood_Neoplasm|Spinal_Cord_Neoplasm	Childhood Spinal Cord Neoplasm|Childhood Spinal Cord Tumor
C9235	Systemic_Mastocytosis	Mast_Cell_Neoplasm	Systemic Mastocytosis|Systemic Tissue Mast Cell Disease	A variant of mastocytosis characterized by multifocal, dense infiltrates of mast cells (15 or more mast cells in aggregates) detected in the bone marrow and/or other extracutaneous sites. (WHO, 2001) -- 2003
C9236	Paroxysmal_Hypertension	Hypertension	Paroxysmal Hypertension
C9237	Recurrent_Gastric_Cancer	Gastric_Carcinoma|Recurrent_Gastrointestinal_System_Cancer	Recurrent Gastric Cancer|Gastric Carcinoma, Recurrent|Recurrent Cancer of Stomach|Recurrent Cancer of the Stomach|Recurrent Carcinoma of Stomach|Recurrent Carcinoma of the Stomach|Recurrent Gastric Carcinoma|Recurrent Stomach Cancer|Recurrent Stomach Carcinoma	The reemergence of gastric cancer after a period of remission.
C9238	Recurrent_Rectal_Cancer	Rectal_Carcinoma|Recurrent_Colorectal_Cancer	Recurrent Rectal Cancer|Rectal Cancer, Recurrent|Recurrent Cancer of Rectum|Recurrent Cancer of the Rectum|Recurrent Rectal Carcinoma	The reemergence of rectal cancer after a period of remission
C9239	Localized_Malignant_Mesothelioma	Malignant_Mesothelioma	Localized Malignant Mesothelioma
C9240	Recurrent_Nasopharyngeal_Carcinoma	Nasopharyngeal_Carcinoma|Recurrent_Pharyngeal_Cancer	Recurrent Nasopharyngeal Cancer|Nasopharyngeal Cancer, Recurrent|Recurrent Cancer of Nasopharynx|Recurrent Cancer of the Nasopharynx|Recurrent Carcinoma of Nasopharynx|Recurrent Carcinoma of the Nasopharynx|Recurrent Nasopharyngeal Carcinoma|Recurrent Nasopharynx Carcinoma|Relapsed Cancer of Nasopharynx|Relapsed Cancer of the Nasopharynx|Relapsed Carcinoma of Nasopharynx|Relapsed Carcinoma of the Nasopharynx|Relapsed Nasopharyngeal Cancer|Relapsed Nasopharyngeal Carcinoma|Relapsed Nasopharynx Carcinoma	The reemergence of nasopharyngeal cancer after a period of remission.
C9241	Recurrent_Hypopharyngeal_Carcinoma	Hypopharyngeal_Carcinoma|Recurrent_Pharyngeal_Cancer	Recurrent Hypopharyngeal Cancer|Recurrent Cancer of Hypopharynx|Recurrent Cancer of the Hypopharynx|Recurrent Carcinoma of Hypopharynx|Recurrent Carcinoma of the Hypopharynx|Recurrent Hypopharyngeal Carcinoma|Recurrent Hypopharynx Carcinoma|Relapsed Cancer of Hypopharynx|Relapsed Cancer of the Hypopharynx|Relapsed Carcinoma of Hypopharynx|Relapsed Carcinoma of the Hypopharynx|Relapsed Hypopharyngeal Cancer|Relapsed Hypopharyngeal Carcinoma|Relapsed Hypopharynx Carcinoma	The reemergence of hypopharyngeal cancer after a period of remission.
C9242	Malignant_Colon_Neoplasm	Colon_Neoplasm|Malignant_Colorectal_Neoplasm	Malignant Colon Neoplasm|Colon Neoplasm, Malignant|Colon Tumor, Malignant|Malignant Colon Tumor|Malignant Colonic Neoplasm|Malignant Colonic Tumor|Malignant Neoplasm of Colon|Malignant Neoplasm of the Colon|Malignant Tumor of Colon|Malignant Tumor of the Colon	A primary or metastatic malignant neoplasm involving the colon.
C9243	Hypertension_Associated_Disorders_of_Pregnancy	Pregnancy_Disorder	Hypertension-Associated Pregnancy Disorder|Hypertension Associated Disorders of Pregnancy
C9244	Aggressive_Non-Hodgkin_s_Lymphoma	Non-Hodgkin_s_Lymphoma_by_Clinical_Course	Aggressive Non-Hodgkin's Lymphoma|Aggressive Lymphoma|aggressive lymphoma	A quickly growing cancer that arises in the cells of the lymphatic system.
C9245	Invasive_Breast_Carcinoma	Breast_Carcinoma	Invasive Breast Carcinoma|Infiltrating Breast Carcinoma|Infiltrating Carcinoma of Breast|Infiltrating Carcinoma of the Breast|Invasive Breast Cancer|Invasive Carcinoma of Breast|Invasive Carcinoma of the Breast	A carcinoma that infiltrates the breast parenchyma.  The vast majority are adenocarcinomas arising from the terminal ductal lobular unit (TDLU).  Often, the invasive adenocarcinoma co-exists with ductal or lobular carcinoma in situ.  It is the most common carcinoma affecting women. --2003
C9246	Stage_IIIB_Inflammatory_Breast_Carcinoma	Inflammatory_Breast_Carcinoma|Stage_IIIB_Breast_Cancer	Stage IIIB Inflammatory Breast Carcinoma|Inflammatory Carcinoma of Breast Stage III|Stage III Inflammatory Breast Cancer|Stage III Inflammatory Breast Carcinoma|Stage IIIB Inflammatory Breast Cancer	Inflammatory breast carcinoma is classified as AJCC Stage IIIB (T4d) unless other criteria indicate more advanced staging.
C9247	Bladder_Granuloma	Granuloma_by_Site	Bladder Granuloma|Urinary Bladder Granuloma
C9248	Silicon_Granuloma	Foreign_Body_Granuloma	Silicon Granuloma
C9249	Recurrent_AIDS-Related_Anal_Canal_Cancer	AIDS-Related_Anal_Carcinoma|Recurrent_Anal_Canal_Cancer	Recurrent AIDS-Related Anal Canal Cancer|Recurrent AIDS-Related Anal Cancer|Recurrent AIDS-Related Anal Carcinoma
C9250	Recurrent_Anaplastic_Large_Cell_Lymphoma	Anaplastic_Large_Cell_Lymphoma|Recurrent_Mature_T-and_NK-Cell_Non-Hodgkin_s_Lymphoma	Recurrent Anaplastic Large Cell Lymphoma|Relapsed Anaplastic Large Cell Lymphoma	The reemergence of anaplastic large cell lymphoma T-and null cell types after a period of remission
C9251	Recurrent_Non-Hodgkin_s_Lymphoma	Non-Hodgkin_s_Lymphoma|Relapsed_Hematologic_Malignancy	Recurrent Non-Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma Relapsed|Recurrent Non-Hodgkin Lymphoma|Relapsed Non-Hodgkin's Lymphoma
C9252	Stage_I_Aggressive_Adult_Non-Hodgkin_s_Lymphoma	Aggressive_Adult_Non-Hodgkin_s_Lymphoma	Stage I Aggressive Adult Non-Hodgkin's Lymphoma|Aggressive Adult Non-Hodgkin's Lymphoma Stage I|Aggressive Adult Non-Hodgkins Lymphoma Stage I|Aggressive Adult NonHodgkin's Lymphoma Stage I|Aggressive Adult NonHodgkins Lymphoma Stage I|Aggressive Stage I Adult Non-Hodgkin's Lymphoma|Stage I Aggressive Adult Non-Hodgkins Lymphoma|Stage I Aggressive Adult NonHodgkin's Lymphoma|Stage I Aggressive Adult NonHodgkins Lymphoma
C9253	Recurrent_Malignant_Pericardial_Mesothelioma	Malignant_Pericardial_Mesothelioma|Recurrent_Malignant_Mesothelioma	Recurrent Pericardial Malignant Mesothelioma
C9254	Recurrent_Malignant_Hemangiopericytoma	Malignant_Hemangiopericytoma	Recurrent Malignant Hemangiopericytoma|Malignant Hemangiopericytoma Recurrent|Relapsed Malignant Hemangiopericytoma	A rare malignant sarcoma, believed to have its origin in smooth muscle derived pericytes, that has recurred after treatment
C9255	Recurrent_Ureter_Cancer	Recurrent_Urinary_Tract_Cancer|Ureter_Carcinoma	Recurrent Ureter Cancer|Recurrent Ureter Carcinoma|Relapsed Cancer of Ureter|Relapsed Cancer of the Ureter|Relapsed Ureter Cancer|Relapsed Ureteral Cancer|Ureteric Cancer, Recurrent	The reemergence of ureter cancer after a period of remission
C9257	Stage_III_Large_Cell_Lung_Carcinoma	Large_Cell_Lung_Carcinoma|Stage_III_Non-Small_Cell_Lung_Cancer	Stage III Large Cell Lung Carcinoma|Stage III Large Cell Carcinoma of Lung|Stage III Large Cell Carcinoma of the Lung
C9259	Aggravated_Granuloma_Annulare	Granuloma_Annulare	Aggravated Granuloma Annulare
C9260	Actinomycotic_Granuloma	Infectious_Granuloma	Actinomycotic Granuloma
C9262	Recurrent_Malignant_Oral_Neoplasm	Malignant_Oral_Neoplasm	Recurrent Malignant Oral Neoplasm
C9263	Recurrent_Malignant_Duodenal_Neoplasm	Malignant_Duodenal_Neoplasm	Recurrent Malignant Duodenal Neoplasm
C9264	Recurrent_Hepatocellular_Carcinoma	Hepatocellular_Carcinoma|Recurrent_Liver_Cancer	Recurrent Hepatocellular Carcinoma|Hepatocellular Carcinoma, Recurrent|Recurrent Carcinoma of Liver Cell|Recurrent Carcinoma of the Liver Cell|Recurrent Hepatoma|Recurrent Liver Cell Carcinoma|Relapsed Carcinoma of Liver Cell|Relapsed Carcinoma of the Liver Cell|Relapsed Hepatocellular Carcinoma|Relapsed Hepatoma|Relapsed Liver Cell Carcinoma	The reemergence of hepatic neoplasm malignant after a period of remission
C9265	Mycosis_Fungoides_and_Sezary_Syndrome	Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma	Mycosis Fungoides and Sezary Syndrome	Mature T and NK neoplasms predominantly affecting the skin and the peripheral blood.  Peripheral blood involvement by abnormal T-cells (cerebriform cells) is a late manifestation of mycosis fungoides, whereas it is the presenting finding in Sezary syndrome. --2003
C9266	Recurrent_Malignant_Bladder_Neoplasm	Malignant_Bladder_Neoplasm	Recurrent Malignant Bladder Neoplasm
C9267	Stage_0a_Bladder_Cancer	Non-Invasive_Bladder_Papillary_Urothelial_Neoplasm|Papillary_Urothelial_Carcinoma|Stage_0_Bladder_Transitional_Cell_Carcinoma	Stage 0a Bladder Cancer|Non-Invasive Papillary Carcinoma of Bladder|Non-Invasive Papillary Carcinoma of Urinary Bladder|Non-Invasive Papillary Carcinoma of the Bladder|Non-Invasive Papillary Carcinoma of the Urinary Bladder|Non-Invasive Papillary Urothelial Carcinoma|Stage 0a Bladder Carcinoma|Stage 0a Carcinoma of Bladder|Stage 0a Carcinoma of Urinary Bladder|Stage 0a Carcinoma of the Bladder|Stage 0a Carcinoma of the Urinary Bladder|Stage 0a Urinary Bladder Carcinoma	A low- or high-grade bladder papillary carcinoma which is confined to the bladder transitional cell epithelium and does not invade into the lamina propria. -- 2003
C9268	Recurrent_Malignant_Nasopharyngeal_Neoplasm	Malignant_Nasopharyngeal_Neoplasm	Recurrent Malignant Nasopharyngeal Neoplasm
C9269	Recurrent_Malignant_Endocervical_Neoplasm	Malignant_Endocervical_Neoplasm	Recurrent Malignant Endocervical Neoplasm
C9270	Advanced_Malignant_Neoplasm	Metastatic_Malignant_Neoplasm	Advanced Malignant Neoplasm|Advanced Cancer
C9271	Postoperative_Hypertension	Hypertension	Postoperative Hypertension
C9272	Salivary_Gland_Carcinoma	Carcinoma|Malignant_Salivary_Gland_Neoplasm	Salivary Gland Carcinoma|Carcinoma of Salivary Gland|Carcinoma of the Salivary Gland	Malignant neoplasm of the salivary glands
C9274	Cardiac_Granuloma	Granuloma_by_Site	Cardiac Granuloma
C9275	Primary_Angiosarcoma	Angiosarcoma	Primary Angiosarcoma|Angiosarcoma Nonmetastatic|Non-Metastatic Angiosarcoma|Non-Metastatic Hemangiosarcoma|Primary Hemangiosarcoma	A rare malignant neoplasm characterized by rapidly proliferating, extensively infiltrating, anaplastic cells derived from blood vessels and lining irregular blood-filled or lumpy spaces. (Stedman, 25th ed) This concept specifically states that there is no evidence of metastases.
C9276	Metastatic_Carcinoma_to_Adrenal_Medulla	Malignant_Adrenal_Medulla_Neoplasm|Metastatic_Carcinoma|Metastatic_Neoplasm_to_the_Adrenal_Gland	Metastatic Carcinoma to the Adrenal Medulla|Adrenal Medulla Carcinoma|Metastatic Carcinoma to Adrenal Medulla	A carcinoma that has spread to the adrenal medulla from an adjacent or distant anatomic site.  (NCI05)
C9277	Testicular_Leukemia	Leukemia|Malignant_Testicular_Neoplasm	Testicular Leukemia	A myeloid or more commonly lymphoid leukemia (acute or chronic) affecting the testis.  Microscopically, there is interstitial infiltration of the testis by leukemic cells.  Acute lymphoblastic leukemia with testicular involvement is not uncommon in boys.  Sometimes (up to 10% of the cases), testicular involvement may be the initial manifestation of relapsed acute lymphoblastic leukemia.  --03
C9278	AIDS-Related_Anal_Carcinoma	AIDS-Related_Carcinoma|AIDS-Related_Malignant_Anal_Neoplasm|Anal_Carcinoma	AIDS-Related Anal Carcinoma|AIDS-Related Anal Cancer
C9279	AIDS-Related_Hodgkin_s_Lymphoma	AIDS-Related_Lymphoma|Hodgkin_s_Lymphoma	AIDS-Related Hodgkin's Lymphoma|AIDS-Associated Hodgkin's Disease|AIDS-Associated Hodgkin's Lymphoma|AIDS-Related Hodgkin Lymphoma|AIDS-Related Hodgkin's Disease|HIV-Associated Hodgkin's Disease|HIV-Associated Hodgkin's Lymphoma|HIV-Related Hodgkin's Disease|HIV-Related Hodgkin's Lymphoma	Hodgkin's lymphoma secondary to AIDS.  An increased incidence of Hodgkin's lymphomas has been observed in HIV positive patients.  Most cases are morphologically classified as lymphocyte depleted or mixed cellularity Hodgkin's lymphomas. -- 2004
C9280	Mediastinal_Thymic_Large_B-Cell_Cell_Lymphoma	Diffuse_Large_B-Cell_Lymphoma|Non-Hodgkin_s_Lymphoma_with_Variable_Clinical_Course|Thymic_Lymphoma	Mediastinal (Thymic) Large B-Cell Lymphoma|B-Cell Diffuse Large Cell Lymphoma of Mediastinum|B-Cell Diffuse Large Cell Lymphoma of the Mediastinum|Mediastinal B-Cell Diffuse Large Cell Lymphoma|Primary Mediastinal Large B-Cell Lymphoma	A large B-cell non-Hodgkin's lymphoma arising in the mediastinum.  Morphologically it is characterized by a massive diffuse lymphocytic proliferation associated with compartmentalizing fibrosis.  Response to intensive chemotherapy, with or without radiotherapy, is usually good. (WHO, 2001) --2003
C9281	Follicular_Dendritic_Cell_Sarcoma	Histiocytic_and_Dendritic_Cell_Neoplasms	Follicular Dendritic Cell Sarcoma/Tumor	A neoplastic proliferation of spindled to ovoid cells which show morphologic and phenotypic features of follicular dendritic cells.  It behaves like a low grade tissue sarcoma. (WHO, 2001) -- 2003
C9282	Interdigitating_Dendritic_Cell_Sarcoma	Histiocytic_and_Dendritic_Cell_Neoplasms	Interdigitating Dendritic Cell Sarcoma/Tumor|Interdigitating Cell Sarcoma/Tumor	A neoplastic proliferation of spindle to ovoid cells which show phenotypic features similar to those of interdigitating dendritic cells.  The clinical course is variable ranging from benign localized disease to widespread lethal disease. (WHO, 2001) -- 2003
C9283	Lymphocyte_Depleted_Hodgkin_s_Lymphoma	Classical_Hodgkin_s_Lymphoma	Lymphocyte Depleted Hodgkin's Lymphoma|Hodgkin Lymphoma Lymphocyte Depleted|Hodgkin's Disease Lymphocyte Depletion|Hodgkin's Lymphoma Lymphocyte Depleted|LDHL|Lymphocyte Depleted Hodgkin's Disease|Lymphocyte-Depleted Classical Hodgkin Lymphoma|Lymphocyte-Depleted Classical Hodgkin's Lymphoma|Lymphocyte-Depleted Hodgkin Lymphoma|Lymphocyte-Depleted Hodgkin's Disease|Lymphocyte-Depleted Hodgkin's Lymphoma	A diffuse form of classical Hodgkin's lymphoma which is rich in Hodgkin's and Reed-Sternberg cells and/or depleted in non-neoplastic lymphocytes.  Historically, the clinical course of this type of Hodgkin's lymphoma was aggressive.  With current therapy, the course is comparable to patients with other subtypes of classical Hodgkin's lymphoma.  Most patients present with advanced stage disease (Stage III or IV) and B-symptoms. (WHO, 2001) -- 2004
C9284	Systemic_Mastocytosis_with_Associated_Clonal_Hematological_non-Mast-Cell_Lineage_Disease	Malignant_Mastocytosis|Primary_Systemic_Mastocytosis	Systemic Mastocytosis with Associated Clonal Hematological non-Mast-Cell Lineage Disease|SM-AHNMD
C9285	Aggressive_Systemic_Mastocytosis	Malignant_Mastocytosis|Primary_Systemic_Mastocytosis	Aggressive Systemic Mastocytosis|ASM
C9286	Indolent_Systemic_Mastocytosis	Primary_Systemic_Mastocytosis	Indolent Systemic Mastocytosis|ISM
C9287	Acute_Myeloid_Leukemia_with_Abnormal_Marrow_Eosinophils	Acute_Myeloid_Leukemia_with_Recurrent_Genetic_Abnormalities	Acute Myeloid Leukemia with Abnormal Marrow Eosinophils|Acute Myeloid Leukemia, CBF-beta/MYH11	An acute myeloid leukemia (AML) with inv(16)(p13q22) or t(16;16)(p13;q22);(CBF-beat/MYH11).  This AML shows monocytic and granulocytic differentiation and the presence of a characteristically abnormal eosinophil component in the bone marrow.  This type of AML has a favorable prognosis.  (WHO, 2001) -- 2003
C9288	Acute_Myeloid_Leukemia_with_t_8_21_q22_q22_AML1_CBFa_ETO	Acute_Myeloid_Leukemia_with_Recurrent_Genetic_Abnormalities	Acute Myeloid Leukemia with t(8;21)(q22;q22)(AML1(CBFa)/ETO)|Acute Myeloid Leukemia with t(8;21)(q22;q22)	An acute myeloid leukemia (AML) showing maturation in the neutrophil lineage.  The bone marrow and the peripheral blood show large myeloblasts with abundant basophilic cytoplasm, often containing azurophilic granules.  This type of AML is associated with good response to chemotherapy and high complete remission rate.  (WHO, 2001) -- 2003
C9289	De_novo_Acute_Myeloid_Leukemia_with_Multilineage_Dysplasia	Acute_Myeloid_Leukemia_with_Multilineage_Dysplasia	De novo Acute Myeloid Leukemia with Multilineage Dysplasia
C9290	Myeloid_Neoplasm	Hematopoietic_Cell_Neoplasm|Malignant_Bone_Marrow_Neoplasm	Myeloid Neoplasm|MPD|Myeloid Malignancy|Myeloid Tumor|Myeloproliferative Disorders|Myeloproliferative Neoplasms|Myeloproliferative Tumors|myeloproliferative disorders	A clonal (malignant) proliferation of myeloid (erythroid, granulocytic, or megakaryocytic) cells originating from a primitive stem cell. -- 2003
C9291	Anal_Carcinoma	Carcinoma|Malignant_Anal_Neoplasm	Anal Carcinoma|Anal Cancer|Cancer of Anus|Cancer of the Anus|Carcinoma of Anus|Carcinoma of the Anus	A carcinoma that arises from the anus.  Anal carcinomas include the anal canal and anal margin (perianal skin) carcinomas.  The anal margin carcinoma is staged separately as a skin carcinoma.  Anal cancer stage terms are usually used as synonyms for anal canal cancer stage terms.  -- 2003
C9292	Solid_Neoplasm	Neoplasm_by_Special_Category	Solid Neoplasm|Solid Tumor|solid tumor	Cancer of body tissues other than blood, bone marrow, or the lymphatic system.
C9293	Central_Nervous_System_Neoplasm	Central_Nervous_System_Disorder|Nervous_System_Neoplasm	Central Nervous System Neoplasm|CNS Neoplasm|CNS Neoplasms|CNS Tumor|CNS tumors|Central Nervous System Neoplasms|Central Nervous System Tumor|Central Nervous System Tumors|Neoplasm of CNS|Neoplasm of Central Nervous System|Neoplasm of the CNS|Neoplasm of the Central Nervous System|Tumor of CNS|Tumor of Central Nervous System|Tumor of the CNS|Tumor of the Central Nervous System	Abnormal growth of cells that comprise the tissues of the central nervous system (brain and spinal cord), without designation of benign or malignant nature.
C9294	Histiocytic_and_Dendritic_Cell_Neoplasms	Hematopoietic_Cell_Neoplasm|Infrequent_Neoplasm	Histiocytic and Dendritic Cell Neoplasms|Histiocytic and Dendritic Cell Tumors	These are rare tumors that affect the hematopoietic and lymphoid tissues.  The cells of origin are the histiocytes and accessory cells. (WHO, 2001) -- 2003
C9295	Mast_Cell_Neoplasm	Hematopoietic_Cell_Neoplasm|Infrequent_Neoplasm	Mast Cell Neoplasm|Mast Cell Proliferative Disease|Mast Cell Tumor|Mastocytosis|Neoplasm of Mast Cells|Neoplasm of the Mast Cells|Tumor of Mast Cells|Tumor of the Mast Cells	A heterogeneous group of disorders characterized by the abnormal growth and accumulation of mast cells in one or more organ systems.  Recent data suggest that most variants of mastocytosis are clonal disorders. (WHO, 2001) -- 2003
C9296	Adenocarcinoma_of_the_Gastroesophageal_Junction	Adenocarcinoma|Malignant_Gastrointestinal_Neoplasm	Adenocarcinoma of the Gastroesophageal Junction|Adenocarcinoma of Cardioesophageal junction|Adenocarcinoma of Gastroesophageal Junction|Adenocarcinoma of the Cardioesophageal junction|Gastroesophageal Junction Adenocarcinoma	Adenocarcinomas that straddle the gastroesophageal junction.  This definition includes adenocarcinomas formerly called carcinomas of the gastric cardia.  These carcinomas are more frequently seen in middle-aged and older white males and are associated with gastro-esophageal reflux.  Adenocarcinomas in the gastroesophageal junction can be graded as well, moderately or poorly differentiated (adapted from WHO, 2000). --2002
C9297	Malignant_Urinary_Tract_Neoplasm	Urinary_Tract_Neoplasm	Malignant Urinary Tract Neoplasm	A primary or metastatic malignant tumor involving the urinary tract.  Common tumor types include carcinomas, lymphomas, and sarcomas. -- 2003
C9298	Stem_Cell_Leukemia	Acute_Leukemia	Stem Cell Leukemia|Leukemia Stem Cell	A leukemia originating from a precursor bone marrow cell which is in an earlier developmental stage compared to lymphoblasts and myeloblasts. -- 2003
C9299	Acute_Undifferentiated_Leukemia	Acute_Leukemia_of_Ambiguous_Lineage	Acute Undifferentiated Leukemia|Undifferentiated Acute Leukemia	An acute leukemia of ambiguous lineage in which the blasts lack sufficient evidence to classify as myeloid or lymphoid.  (WHO, 2001) -- 2003
C9300	Acute_Leukemia	Leukemia	Acute Leukemia|acute leukemia	A clonal (malignant) hematopoietic disorder affecting the bone marrow and the peripheral blood.  The malignant cells show minimal differentiation and are called blasts, either myeloid blasts (myeloblasts) or lymphoid blasts (lymphoblasts).  According to the type of blasts present, acute leukemias are classified as acute myeloid leukemia (AML) and precursor lymphoblastic or acute lymphoblastic leukemia (ALL). -- 2004
C9301	Central_Nervous_System_Lymphoma	Central_Nervous_System_Hematopoietic_Neoplasm|Lymphoma_by_Site|Malignant_Central_Nervous_System_Neoplasm	Central Nervous System Lymphoma|CNS Lymphoma|Malignant Lymphomas of CNS|Malignant Lymphomas of the CNS|Primary CNS Lymphoma|Primary Central Nervous System Lymphoma|primary central nervous system lymphoma	A non-Hodgkin's or Hodgkin's lymphoma arising in the brain and/or the spinal cord. --2003
C9302	Primary_Central_Nervous_System_Lymphoma	Retired_Concepts	Primary Central Nervous System Lymphoma|Primary CNS Lymphoma|primary central nervous system lymphoma	Cancer that arises in the lymphoid tissue found in the central nervous system (CNS). The CNS includes the brain and spinal cord.
C9303	Mastocytoma	Mast_Cell_Neoplasm	Mastocytoma|mastocytoma	A nodule of mast cells.  Mastocytomas can involve the skin, subcutaneous tissue, and sometimes muscle. Also called a mast cell tumor.
C9304	Mastocytosis	Retired_Concepts	Mastocytosis
C9305	Malignant_Neoplasm	Neoplasm_by_Special_Category	Malignant Neoplasm|CA|Cancer|Malignancy|Malignant Tumor|cancer|malignancy	A term for diseases in which abnormal cells divide without control. Cancer cells can invade nearby tissues and can spread through the bloodstream and lymphatic system to other parts of the body.
C9306	Soft_Tissue_Sarcoma	Malignant_Soft_Tissue_Neoplasm|Sarcoma_of_the_Soft_Tissue_and_Bone	Soft Tissue Sarcoma|Connective Tissue Sarcoma|Sarcoma of Soft Tissue|Sarcoma of the Soft Tissue|soft tissue sarcoma	(TISH-oo sar-KO-ma) A sarcoma that begins in the muscle, fat, fibrous tissue, blood vessels, or other supporting tissue of the body.
C9307	Lymphadenopathy_with_Polyclonal_Hypergammaglobulinemia	Lymphadenopathy	Lymphadenopathy with Polyclonal Hypergammaglobulinemia
C9308	Lymphoproliferative_Disorder	Hematologic_Disorder	Lymphoproliferative Disorder|lymphoproliferative disorders	A disorder characterized by proliferation of lymphocytes at various stages of differentiation. Lymphoproliferative disorders can be neoplastic (clonal, as in lymphomas and leukemias) or reactive (polyclonal, as in infectious mononucleosis). --2004
C9309	Seminoma	Malignant_Germ_Cell_Neoplasm	Seminoma|Seminoma, Pure|seminoma	(sem-in-O-ma) A type of cancer of the testicles. Seminomas may spread to the lung, bone, liver, or brain.
C9310	Extragonadal_Primary_Seminoma	Extragonadal_Seminoma	Extragonadal Primary Seminoma|Primary Extragonadal Seminoma
C9311	Malignant_Cervical_Neoplasm	Cervical_Neoplasm|Malignant_Uterine_Neoplasm	Malignant Cervical Neoplasm|Malignant Cervical Tumor|Malignant Cervix Neoplasm|Malignant Cervix Tumor|Malignant Cervix Uteri Neoplasm|Malignant Cervix Uteri Tumor|Malignant Neoplasm of Cervix|Malignant Neoplasm of Cervix Uteri|Malignant Neoplasm of Uterine Cervix|Malignant Neoplasm of the Cervix|Malignant Neoplasm of the Cervix Uteri|Malignant Neoplasm of the Uterine Cervix|Malignant Tumor of Cervix|Malignant Tumor of Cervix Uteri|Malignant Tumor of Uterine Cervix|Malignant Tumor of the Cervix|Malignant Tumor of the Cervix Uteri|Malignant Tumor of the Uterine Cervix|Malignant Uterine Cervix Neoplasm|Malignant Uterine Cervix Tumor	Primary or metastatic malignant neoplasm involving the cervix. --2003
C9312	Bone_Sarcoma	Malignant_Bone_Neoplasm|Sarcoma_of_the_Soft_Tissue_and_Bone	Bone Sarcoma|Osseous Sarcoma|Sarcoma of Bone|Sarcoma of the Bone|Skeletal Sarcoma	A malignant mesenchymal tumor of the bone.  Bone sarcomas can either arise from the bones (primary bone sarcomas) or spread to the bones from other anatomic sites. --2003
C9313	Testicular_Non-Seminomatous_Germ_Cell_Tumor	Testicular_Germ_Cell_Neoplasm	Testicular Non-Seminomatous Germ Cell Tumor|Testicular Germ Cell Tumor Non-Seminomatous
C9314	Malignant_Oral_Cavity_Neoplasm	Malignant_Oral_Neoplasm|Oral_Cavity_Neoplasm	Malignant Oral Cavity Neoplasm|Malignant Mouth Neoplasm|Malignant Mouth Tumor|Malignant Neoplasm of Mouth|Malignant Neoplasm of the Mouth|Malignant Oral Cavity Tumor|Malignant Tumor of Mouth|Malignant Tumor of the Mouth	A primary or metastatic malignant tumor involving the oral cavity.  The majority are squamous cell carcinomas. -- 2003
C9315	Lip_and_Oral_Cavity_Carcinoma	Carcinoma|Malignant_Oral_Neoplasm	Lip and Oral Cavity Carcinoma|Lip and Oral Cavity Cancer	A carcinoma arising in the lip or oral cavity.  Most oral cavity carcinomas are squamous cell carcinomas of the tongue, buccal mucosa, or gums.  Less frequent morphologic variants include mucoepidermoid carcinoma and adenocarcinoma.  Lip carcinomas are usually basal cell or squamous cell carcinomas. -- 2004
C9316	Malignant_Oral_Neoplasm	Oral_Neoplasm	Malignant Oral Neoplasm	A malignant tumor involving the lip and/or oral cavity.  The majority are carcinomas. -- 2003
C9317	Malignant_Gingival_Neoplasm	Gingival_Neoplasm|Malignant_Oral_Cavity_Neoplasm	Malignant Gingival Neoplasm|Malignant Gingival Tumor|Malignant Gum Neoplasm|Malignant Gum Tumor|Malignant Neoplasm of Gingiva|Malignant Neoplasm of Gum|Malignant Neoplasm of the Gingiva|Malignant Neoplasm of the Gum|Malignant Tumor of Gingiva|Malignant Tumor of Gum|Malignant Tumor of the Gingiva|Malignant Tumor of the Gum
C9318	Malignant_Floor_of_the_Mouth_Neoplasm	Floor_of_the_Mouth_Neoplasm|Malignant_Oral_Cavity_Neoplasm	Malignant Floor of the Mouth Neoplasm|Malignant Floor of Mouth Neoplasm|Malignant Floor of Mouth Tumor|Malignant Floor of the Mouth Tumor|Malignant Neoplasm of Floor of Mouth|Malignant Neoplasm of the Floor of the Mouth|Malignant Tumor of Floor of Mouth|Malignant Tumor of the Floor of the Mouth
C9319	Floor_of_the_Mouth_Carcinoma	Malignant_Floor_of_the_Mouth_Neoplasm|Oral_Cavity_Carcinoma	Floor of the Mouth Carcinoma|Carcinoma of Floor of Mouth|Carcinoma of the Floor of the Mouth|Floor of Mouth Carcinoma|Mouth Floor Cancer
C9320	Malignant_Buccal_Mucosa_Neoplasm	Buccal_Mucosa_Neoplasm|Malignant_Oral_Cavity_Neoplasm	Malignant Buccal Mucosa Neoplasm|Malignant Buccal Mucosa Tumor|Malignant Neoplasm of Buccal Mucosa|Malignant Neoplasm of the Buccal Mucosa|Malignant Tumor of Buccal Mucosa|Malignant Tumor of the Buccal Mucosa
C9321	Malignant_Nasopharyngeal_Neoplasm	Malignant_Pharyngeal_Neoplasm|Nasopharyngeal_Neoplasm	Malignant Nasopharyngeal Neoplasm|Malignant Nasopharyngeal Tumor|Malignant Neoplasm of Nasopharynx|Malignant Neoplasm of the Nasopharynx|Malignant Tumor of Nasopharynx|Malignant Tumor of the Nasopharynx
C9322	Malignant_Parathyroid_Neoplasm	Malignant_Neck_Neoplasm|Parathyroid_Neoplasm	Malignant Parathyroid Gland Neoplasm|Malignant Neoplasm of Parathyroid|Malignant Neoplasm of Parathyroid Gland|Malignant Neoplasm of the Parathyroid|Malignant Neoplasm of the Parathyroid Gland|Malignant Parathyroid Gland Tumor|Malignant Parathyroid Neoplasm|Malignant Parathyroid Tumor|Malignant Tumor of Parathyroid|Malignant Tumor of Parathyroid Gland|Malignant Tumor of the Parathyroid|Malignant Tumor of the Parathyroid Gland	A primary or metastatic malignant neoplasm affecting the parathyroid glands. (NCI05)
C9323	Malignant_Postcricoid_Neoplasm	Malignant_Hypopharyngeal_Neoplasm	Malignant Postcricoid Neoplasm|Malignant Neoplasm of Postcricoid Area|Malignant Neoplasm of the Postcricoid Area|Malignant Postcricoid Tumor|Malignant Tumor of Postcricoid Area|Malignant Tumor of the Postcricoid Area
C9324	Adrenal_Gland_Carcinoma	Retired_Concepts	Adrenal Gland Carcinoma|Adrenal Carcinoma|Carcinoma of Adrenal Gland|Carcinoma of the Adrenal Gland	A carcinoma arising from the adrenal cortical cells.  Adrenal cortex carcinomas (ACCs) are rare, comprising between only 0.05% and 0.2% of all cancers. Functional ACCs are more common in women while nonfunctioning ACCs are more common in men. Hypercortisolism is the most common hormonal abnormality observed in this cancer; patients may also present with virilism or Cushing's syndrome. --2004
C9325	Adrenal_Cortex_Carcinoma	Adenocarcinoma|Infrequent_Neoplasm|Malignant_Adrenal_Cortex_Neoplasm|Malignant_Endocrine_Neoplasm	Adrenal Cortex Carcinoma|Adrenal Cortex Adenocarcinoma|Adrenal Cortex Cancer|Adrenal Cortical Adenocarcinoma|Adrenal Cortical Carcinoma|Adrenocortical Carcinoma|Carcinoma of Adrenal Cortex|Carcinoma of the Adrenal Cortex	A rare, usually large (greater than 5cm), malignant epithelial tumor arising from the adrenal cortical cells.  Symptoms are usually related to the excessive production of hormones, and include Cushing's syndrome and virilism in women.  Common sites of metastasis include liver, lung, bone, and retroperitoneal lymph nodes.  Advanced radiologic procedures have enabled the detection of small tumors, resulting in the improvement of the 5-year survival.  (NCI05)
C9326	Adrenal_Cortex_Adenocarcinoma	Retired_Concepts	Adrenal Cortex Adenocarcinoma|Adrenal Cortical Adenocarcinoma	A carcinoma arising from the adrenal cortical cells.  Adrenal cortex carcinomas (ACCs) are rare, comprising between only 0.05% and 0.2% of all cancers. Functional ACCs are more common in women while nonfunctioning ACCs are more common in men. Hypercortisolism is the most common hormonal abnormality observed in this cancer; patients may also present with virilism or Cushing's syndrome. --2004
C9327	Malignant_Adrenal_Cortex_Neoplasm	Adrenal_Cortex_Neoplasm|Malignant_Adrenal_Gland_Neoplasm	Malignant Adrenal Cortex Neoplasm|Malignant Adrenal Cortex Tumor|Malignant Adrenocortical Neoplasm|Malignant Adrenocortical Tumor|Malignant Neoplasm of Adrenal Cortex|Malignant Neoplasm of the Adrenal Cortex|Malignant Tumor of Adrenal Cortex|Malignant Tumor of the Adrenal Cortex	A primary (adrenal cortex carcinoma) or a metastatic malignant neoplasm affecting the adrenal cortex. (NCI05)
C9328	Malignant_Duodenal_Neoplasm	Duodenal_Neoplasm|Malignant_Small_Intestinal_Neoplasm	Malignant Duodenal Neoplasm|Malignant Duodenal Tumor|Malignant Neoplasm of Duodenum|Malignant Neoplasm of the Duodenum|Malignant Tumor of Duodenum|Malignant Tumor of the Duodenum
C9329	Malignant_Cecum_Neoplasm	Cecum_Neoplasm|Malignant_Colon_Neoplasm	Malignant Cecum Neoplasm|Malignant Cecum Tumor|Malignant Neoplasm of Cecum|Malignant Neoplasm of the Cecum|Malignant Tumor of Cecum|Malignant Tumor of the Cecum
C9330	Appendix_Carcinoma	Carcinoma|Malignant_Appendix_Neoplasm	Appendix Carcinoma|Cancer of Appendix|Cancer of the Appendix|Carcinoma of Appendix|Carcinoma of the Appendix
C9331	Malignant_Gastric_Neoplasm	Gastric_Neoplasm|Malignant_Gastrointestinal_Neoplasm	Malignant Gastric Neoplasm|Malignant Gastric Tumor|Malignant Neoplasm of Stomach|Malignant Neoplasm of the Stomach|Malignant Tumor of Stomach|Malignant Tumor of the Stomach	Primary or metastatic malignant neoplasm of the stomach
C9332	Maxillary_Sinus_Carcinoma	Malignant_Maxillary_Sinus_Neoplasm	Maxillary Sinus Carcinoma|Maxillary Sinus Cancer
C9333	Malignant_Appendix_Neoplasm	Appendix_Neoplasm|Malignant_Gastrointestinal_Neoplasm	Malignant Appendix Neoplasm|Malignant Appendix Tumor|Malignant Neoplasm of Appendix|Malignant Neoplasm of Appendix Vermiformis|Malignant Neoplasm of the Appendix|Malignant Tumor of Appendix|Malignant Tumor of the Appendix
C9334	Malignant_Bladder_Neoplasm	Bladder_Neoplasm|Malignant_Urinary_Tract_Neoplasm	Malignant Bladder Neoplasm|Malignant Bladder Tumor|Malignant Neoplasm of Bladder|Malignant Neoplasm of Urinary Bladder|Malignant Neoplasm of the Bladder|Malignant Neoplasm of the Urinary Bladder|Malignant Neoplasm, Bladder|Malignant Neoplasm, Urinary Bladder|Malignant Tumor of Bladder|Malignant Tumor of Urinary Bladder|Malignant Tumor of the Bladder|Malignant Tumor of the Urinary Bladder|Malignant Tumor, Urinary Bladder|Malignant Urinary Bladder Neoplasm|Malignant Urinary Bladder Tumor|Urinary Bladder Malignant Neoplasm|Urinary Bladder Malignant Tumor	A primary or metastatic malignant neoplasm involving the bladder. - 2003
C9335	Malignant_Breast_Neoplasm	Breast_Neoplasm	Malignant Breast Neoplasm|Malignant Breast Tumor|Malignant Neoplasm of Breast|Malignant Neoplasm of the Breast|Malignant Tumor of Breast|Malignant Tumor of the Breast	A primary or metastatic malignant neoplasm involving the breast.  The vast majority of cases are carcinomas arising from the breast parenchyma or the nipple.  Malignant breast neoplasms occur more frequently in females than in males. -- 2003
C9336	Nasal_Cavity_Carcinoma	Carcinoma|Malignant_Nasal_Cavity_Neoplasm	Nasal Cavity Carcinoma|Cancer of Nasal Cavity|Cancer of the Nasal Cavity|Carcinoma of Nasal Cavity|Carcinoma of the Nasal Cavity|Nasal Cavity Cancer	Malignant neoplasm of the nasal cavity
C9337	Malignant_Ear_Neoplasm	Ear_Neoplasm	Malignant Ear Neoplasm|Malignant Ear Tumor|Malignant Neoplasm of Ear|Malignant Neoplasm of the Ear|Malignant Tumor of Ear|Malignant Tumor of the Ear
C9338	Malignant_Adrenal_Gland_Neoplasm	Adrenal_Gland_Neoplasm|Malignant_Retroperitoneal_Neoplasm	Malignant Adrenal Gland Neoplasm|Malignant Adrenal Gland Tumor|Malignant Adrenal Neoplasm|Malignant Adrenal Tumor|Malignant Neoplasm of Adrenal Gland|Malignant Neoplasm of the Adrenal Gland|Malignant Tumor of Adrenal Gland|Malignant Tumor of the Adrenal Gland	A primary or metastatic malignant neoplasm affecting the adrenal gland. (NCI05)
C9339	Refractory_Peripheral_T-Cell_Lymphoma_Unspecified	Refractory_Mature_T-Cell_and_NK-Cell_Non-Hodgkin_s_Lymphoma|Unspecified_Peripheral_T-Cell_Lymphoma	Refractory Unspecified Peripheral T-Cell Lymphoma	Peripheral T-cell lymphoma unspecified resistant to treatment
C9341	Peripheral_Primitive_Neuroectodermal_Tumor	Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor	Peripheral Primitive Neuroectodermal Tumor|Peripheral Neuroectodermal Neoplasm|Peripheral Neuroectodermal Tumor|Peripheral Neuroepithelioma|Peripheral PNET|Peripheral Primitive Neuroectodermal Neoplasm|Peripheral Primitive Neuroectodermal Tumors|pPNET
C9342	Spindle_Cell_Intraocular_Melanoma	Retired_Concepts	Spindle Cell Intraocular Melanoma	Intraocular Melanoma is derived from melanocytes of the uveal tract.  This tumor is the most common primary intraocular tumor in the United States and Western Europe.  Simular to melanoma of the skin it is rare in Africa and Asia.  Diagnostic procedures include ophthalmoscopic exam, flurescein angiograph and ultrasound.  Treatment includes: surgical excision of the eye, iridocyclectomy and tumor resection.  Recently treatment as also included radiotherapy or photo coagulation.  Classification of uveal melanomas recognizes four cell types within these tumors. Spindle A and B cells are included in this classification. - 2002
C9343	Bone_Neoplasm	Connective_Tissue_Disorder|Connective_and_Soft_Tissue_Neoplasm	Bone Neoplasm|Bone Neoplasms|Bone Tumor|Bone Tumors|Neoplasm of Bone|Neoplasm of the Bone|Osseous Neoplasm|Osseous Tumor|Tumor of Bone|Tumor of the Bone	A benign or malignant (primary or metastatic) tumor involving the bone.  Common malignant tumor types involving the bones are metastatic carcinomas and sarcomas. -- 2003
C9344	Pineoblastoma	Embryonal_Neoplasm_of_the_CNS|Malignant_Pineal_Region_Neoplasm|Pineal_Parenchymal_Cell_Neoplasm	Pineoblastoma|PNET of Pineal Gland|PNET of the Pineal Gland|Pineal Gland PNET|Pineal Gland Primitive Neuroectodermal Neoplasm|Pineal Gland Primitive Neuroectodermal Tumor|Pineal PNET|Pineal Primitive Neuroectodermal Neoplasm|Pineal Primitive Neuroectodermal Tumor|Primitive Neuroectodermal Neoplasm of Pineal Gland|Primitive Neuroectodermal Neoplasm of the Pineal Gland|Primitive Neuroectodermal Tumor of Pineal Gland|Primitive Neuroectodermal Tumor of the Pineal Gland|pineoblastoma	(PIN-ee-o-blas-TOE-ma) A fast growing type of brain tumor that occurs in or around the pineal gland, a tiny organ near the center of the brain.
C9345	Malignant_Tongue_Neoplasm	Tongue_Neoplasm	Malignant Tongue Neoplasm|Malignant Neoplasm of Tongue|Malignant Neoplasm of the Tongue|Malignant Tongue Tumor|Malignant Tumor of Tongue|Malignant Tumor of the Tongue|Tongue Neoplasm Malignant Stage Unspecified|Tongue Neoplasm, Malignant	Abnormal growth, with malignant characteristics, of the cells that comprise the tongue.
C9346	Malignant_Tracheal_Neoplasm	Malignant_Respiratory_Tract_Neoplasm|Tracheal_Neoplasm	Malignant Tracheal Neoplasm|Malignant Neoplasm of Trachea|Malignant Neoplasm of the Trachea|Malignant Trachea Neoplasm|Malignant Trachea Tumor|Malignant Tracheal Tumor|Malignant Tumor of Trachea|Malignant Tumor of the Trachea	A primary or metastatic malignant neoplasm involving the trachea
C9347	Tracheal_Carcinoma	Carcinoma|Infrequent_Neoplasm|Malignant_Tracheal_Neoplasm	Tracheal Carcinoma|Cancer of Trachea|Cancer of the Trachea|Carcinoma of Trachea|Carcinoma of the Trachea|Trachea Cancer|Trachea Carcinoma	Malignant neoplasms of the trachea
C9348	Mast_Cell_Sarcoma	Malignant_Mastocytosis	Mast Cell Sarcoma|MCS	A rare entity characterized by localized but destructive growth of a tumor consisting of highly atypical, immature mast cells.(WHO, 2001) -- 2003
C9349	Plasmacytoma	Plasma_Cell_Neoplasm	Plasmacytoma|plasmacytoma	(PLAS-ma-sye-TOE-ma) Cancer of the plasma cells (white blood cells that produce antibodies) that may turn into multiple myeloma.
C9350	Malignant_Peritoneal_Mesothelioma	Malignant_Mesothelioma|Malignant_Peritoneal_Neoplasm|Peritoneal_Mesothelioma	Peritoneal Malignant Mesothelioma|Malignant Mesothelioma of Peritoneum|Malignant Mesothelioma of the Peritoneum|Malignant Peritoneal Mesothelioma
C9351	Pleural_Mesothelioma	Mesothelioma|Pleural_Neoplasm	Pleural Mesothelioma|Mesothelioma of Pleura|Mesothelioma of the Pleura
C9352	Recurrent_Duodenal_Cancer	Duodenal_Carcinoma|Recurrent_Malignant_Duodenal_Neoplasm	Recurrent Duodenal Cancer
C9353	Recurrent_Malignant_Hypopharyngeal_Neoplasm	Malignant_Hypopharyngeal_Neoplasm	Recurrent Malignant Hypopharyngeal Neoplasm	The reemergence of hypopharyngeal cancer after a period of remission.
C9354	Recurrent_Malignant_Gastric_Neoplasm	Malignant_Gastric_Neoplasm	Recurrent Malignant Gastric Neoplasm
C9355	Stage_IVB_Vaginal_Cancer	Stage_IV_Vaginal_Cancer	Stage IVB Vaginal Cancer|AJCC Stage IVB Vaginal Cancer|FIGO Stage IVB Carcinoma of Vagina|FIGO Stage IVB Carcinoma of the Vagina|FIGO Stage IVB Vagina Carcinoma|FIGO Stage IVB Vaginal Carcinoma|Metastatic Vaginal Cancer|Metastatic Vaginal Carcinoma|Vaginal Cancer Stage IVB	Stage IVB includes: Any T, Any N, M1. M1: Distant metastasis. (AJCC 6th ed.) - 2003
C9356	Regional_Ureter_Cancer	Regional_Malignant_Ureter_Neoplasm|Ureter_Carcinoma	Regional Ureter Cancer|Regional Ureter Carcinoma|Regional Ureteric Cancer|Regional Ureteric Carcinoma	Carcinoma of the ureter without spread to any other region.
C9357	Hodgkin_s_Lymphoma	Common_Hematopoietic_Neoplasm|Lymphoma	Hodgkin's Lymphoma|HL|Hodgkin Lymphoma|Hodgkin's Disease|Hodgkin's disease|Hodgkins Disease|Hodgkins Lymphoma	A lymphoma, previously known as Hodgkin's disease, characterized by the presence of Reed-Sternberg cells.  There are two distinct subtypes: nodular lymphocyte predominant Hodgkin's lymphoma and classical Hodgkin's lymphoma.  Hodgkin's lymphoma has a bimodal age distribution, and involves primarily lymph nodes.  Current therapy for Hodgkin's lymphoma has resulted in an excellent outcome and cure for the majority of patients. -- 2003
C9358	Stage_I_Colon_Cancer	Colon_Carcinoma|Stage_I_Colorectal_Cancer	Stage I Colon Cancer|AJCC Stage I Colon Cancer|Colon Cancer Stage I|Colon Cancer, Stage I|Dukes A Carcinoma of Colon|Dukes A Carcinoma of the Colon|Dukes A Colon Carcinoma|Dukes A Colonic Carcinoma|Stage I Carcinoma of Colon|Stage I Carcinoma of the Colon|Stage I Colon Carcinoma|Stage I Colonic Carcinoma	Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003
C9359	Pigmented_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma	Skin Pigmented Basal Cell Carcinoma	Typically this basal cell carcinoma has a nodular growth pattern and contains large amounts of melanin.  The melanin is produced by symbiotic nontumoral proliferating melanocytes. - 2002.
C9360	Precursor_Lymphoblastic_Lymphoma	Non-Hodgkin_s_Lymphoma|Precursor_Lymphoblastic_Leukemia_Lymphoma	Precursor Lymphoblastic Lymphoma|Lymphoblastic Lymphoma|Precursor Cell Lymphoblastic Lymphoma
C9361	Adult_Lymphoblastic_Lymphoma	Adult_Non-Hodgkin_s_Lymphoma|Precursor_Lymphoblastic_Lymphoma	Adult Lymphoblastic Lymphoma
C9362	Clitoral_Carcinoma	Malignant_Clitoral_Neoplasm|Vulvar_Carcinoma	Clitoral Carcinoma|Carcinoma of Clitoris|Carcinoma of the Clitoris|Clitoral Cancer|Clitoris Carcinoma
C9363	Labia_Majora_Carcinoma	Malignant_Labia_Majora_Neoplasm|Vulvar_Carcinoma	Labia Majora Carcinoma|Carcinoma of Labia Majora|Carcinoma of the Labia Majora|Labia Majora Cancer
C9364	Labia_Minora_Carcinoma	Malignant_Labia_Minora_Neoplasm|Vulvar_Carcinoma	Labia Minora Carcinoma|Carcinoma of Labia Minora|Carcinoma of the Labia Minora|Labia Minora Cancer
C9365	Stage_IIA_Bladder_Cancer	Stage_II_Bladder_Cancer	Stage IIA Bladder Cancer|Jewett-Marshall Stage B1 Bladder Cancer|Jewett-Marshall Stage B1 Urinary Bladder Cancer|Jewett-Marshall Stage B1 Urinary Bladder Carcinoma|Stage IIA Urinary Bladder Cancer|Stage IIA Urinary Bladder Carcinoma
C9366	Stage_IIB_Bladder_Cancer	Stage_II_Bladder_Cancer	Stage IIB Bladder Cancer|Jewett-Marshall Stage B2 Bladder Cancer|Jewett-Marshall Stage B2 Bladder Carcinoma|Jewett-Marshall Stage B2 Urinary Bladder Carcinoma|Stage IIB Urinary Bladder Cancer|Stage IIB Urinary Bladder Carcinoma
C9367	Stage_IVA_Bladder_Cancer	Stage_IV_Bladder_Cancer	Stage IVA Bladder Cancer|Jewett-Marshall Stage D1 Bladder Cancer|Jewett-Marshall Stage D1 Urinary Bladder Cancer|Jewett-Marshall Stage D1 Urinary Bladder Carcinoma|Stage IVA Urinary Bladder Cancer|Stage IVA Urinary Bladder Carcinoma	Stage IV includes T4b, NO,MO/any T NI, MO/ any T N2 MO,/ any T N3 MO/ any T any N M1 : T4b: Tumor invades the pelvic wall, abdominal wall. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension. N3: Metastasis in a lymph node more than 5 cm in greatest dimension. M1: Distant metastasis.
C9368	Stage_IVB_Bladder_Cancer	Stage_IV_Bladder_Cancer	Stage IVB Bladder Cancer|Jewett-Marshall Stage D2 Bladder Cancer|Jewett-Marshall Stage D2 Urinary Bladder Cancer|Jewett-Marshall Stage D2 Urinary Bladder Carcinoma|Stage IVB Urinary Bladder Cancer|Stage IVB Urinary Bladder Carcinoma	Stage IV includes T4b, NO,MO/any T NI, MO/ any T N2 MO,/ any T N3 MO/ any T any N M1 : T4b: Tumor invades the pelvic wall, abdominal wall. N1: Metastasis in a single lymph node, 2 cm or less in greatest dimension. N2: Metastasis in a single lymph node, more than 2 cm but not more than 5 cm in greatest dimension; or multiple lymph nodes, none more than 5 cm in greatest dimension. N3: Metastasis in a lymph node more than 5 cm in greatest dimension. M1: Distant metastasis.
C9369	Recurrent_Testicular_Cancer	Malignant_Testicular_Germ_Cell_Tumor	Recurrent Testicular Cancer|Recurrent Cancer of Testis|Recurrent Cancer of the Testis|Recurrent Carcinoma of Testis|Recurrent Carcinoma of the Testis|Recurrent Testicular Carcinoma|Relapsed Cancer of Testis|Relapsed Cancer of the Testis|Relapsed Carcinoma of Testis|Relapsed Carcinoma of the Testis|Relapsed Testicular Cancer|Relapsed Testicular Carcinoma
C9370	Adult_Brain_Stem_Gliosarcoma	Adult_Brain_Stem_Glioma|Gliosarcoma	Adult Brain Stem Gliosarcoma|Adult Brainstem Gliosarcoma
C9371	Adult_Brain_Stem_Mixed_Glioma	Adult_Brain_Stem_Glioma|Mixed_Glioma	Adult Brain Stem Mixed Glioma|Adult Brainstem Mixed Glioma
C9372	Adult_Brain_Ependymoma	Adult_Ependymoma|Ependymal_Tumor_of_Brain	Adult Brain Ependymoma
C9373	Adult_Brain_Medulloblastoma	Adult_Medulloblastoma	Adult Brain Medulloblastoma
C9374	Adult_Brain_Meningioma	Adult_Meningioma|Intracranial_Meningioma	Adult Brain Meningioma
C9375	Adult_Brain_Glioblastoma	Adult_Glioblastoma|Brain_Glioblastoma	Adult Brain Glioblastoma|Adult Brain Glioblastoma Multiforme|Grade IV Adult Brain Astrocytoma
C9376	Adult_Brain_Oligodendroglioma	Adult_Oligodendroglioma|Brain_Oligodendroglioma	Adult Brain Oligodendroglioma
C9377	Brain_Oligodendroglioma	Oligodendroglioma	Brain Oligodendroglioma|Oligodendroglioma of Brain|Oligodendroglioma of the Brain
C9378	Childhood_Myeloid_Leukemia_in_Remission	Myeloid_Leukemia_in_Remission	Childhood Myeloid Leukemia in Remission|Childhood Nonlymphocytic Leukemia in Remission
C9379	Adenocarcinoma_and_Small_Cell_Lung_Carcinoma	Combined_Type_Small_Cell_Lung_Carcinoma	Combined Small Cell Lung Carcinoma and Lung Adenocarcinoma|Adenocarcinoma and Small Cell Carcinoma of Lung|Adenocarcinoma and Small Cell Carcinoma of the Lung|Adenocarcinoma and Small Cell Lung Carcinoma	A lung carcinoma characterized by a combination of small cell carcinoma and adenocarcinoma. (NCI05)
C9380	Adult_Acute_Myeloid_Leukemia_without_Maturation	Acute_Myeloid_Leukemia_without_Maturation|Adult_Acute_Myeloid_Leukemia	Adult Acute Myeloid Leukemia without Maturation|Adult Acute Granulocytic Leukemia without Maturation|Adult Acute Myeloblastic Leukemia|Adult Acute Myeloblastic Leukemia without Maturation|Adult Acute Myeloblastic Leukemia without Maturation (M1)|Adult Acute Myelogenous Leukemia without Maturation|M1 Adult Acute Granulocytic Leukemia|M1 Adult Acute Granulocytic Leukemia without Maturation|M1 Adult Acute Myeloblastic Leukemia|M1 Adult Acute Myelocytic Leukemia|M1 Adult Acute Myelogenous Leukemia|M1 Adult Acute Myelogenous Leukemia without Maturation|M1 Adult Acute Myeloid Leukemia|M1 Adult Acute Myeloid Leukemia without Maturation
C9381	Childhood_Acute_Myeloid_Leukemia_with_Maturation	Acute_Myeloid_Leukemia_with_Maturation|Childhood_Acute_Myeloid_Leukemia	Childhood Acute Myeloid Leukemia with Maturation|Childhood Acute Granulocytic Leukemia with Maturation|Childhood Acute M2 Leukemia|Childhood Acute Myeloblastic Leukemia with Maturation|Childhood Acute Myeloblastic Leukemia with Maturation (M2)|Childhood Acute Myelocytic Leukemia with Maturation|Childhood Acute Myelogenous Leukemia with Maturation|M2 Childhood AGL|M2 Childhood Acute Myeloblastic Leukemia with Maturation|M2 Childhood Acute Myelocytic Leukemia with Maturation|M2 Childhood Acute Myelogenous Leukemia|M2 Childhood Acute Myelogenous Leukemia with Maturation|M2 Childhood Acute Myeloid Leukemia with Maturation|M2 Pediatric AGL|M2 Pediatric Acute Granulocytic Leukemia with Maturation|M2 Pediatric Acute Myeloblastic Leukemia with Maturation|M2 Pediatric Acute Myelocytic Leukemia with Maturation|M2 Pediatric Acute Myelogenous Leukemia|M2 Pediatric Acute Myelogenous Leukemia with Maturation|M2 Pediatric Acute Myeloid Leukemia with Maturation|Pediatric AGL with Maturation|Pediatric Acute Granulocytic Leukemia with Maturation|Pediatric Acute M2 Leukemia|Pediatric Acute Myeloblastic Leukemia with Maturation|Pediatric Acute Myelocytic Leukemia with Maturation|Pediatric Acute Myelogenous Leukemia with Maturation|Pediatric Acute Myeloid Leukemia with Maturation
C9382	Rectal_Carcinoma	Colorectal_Carcinoma|Malignant_Rectal_Neoplasm	Rectal Carcinoma|Cancer of Rectum|Cancer of the Rectum|Carcinoma of Rectum|Carcinoma of the Rectum|Rectal Cancer	A malignant tumor arising from the epithelium of the rectal mucosa.  Most rectal carcinomas are adenocarcinomas; squamous cell carcinomas of the rectum are also seen.  Prognosis depends on tumor stage (depth of wall invasion, lymph node involvement, presence of distal metastases). -- 2004
C9383	Rectal_Adenocarcinoma	Colorectal_Adenocarcinoma|Rectal_Carcinoma	Rectal Adenocarcinoma|Adenocarcinoma of Rectum|Adenocarcinoma of the Rectum
C9384	Renal_Carcinoma	Carcinoma|Malignant_Renal_Neoplasm	Renal Carcinoma|Kidney Cancer|Kidney Carcinoma|Renal Cancer	A carcinoma arising from the epithelium of the renal parenchyma (renal cell carcinoma) or the renal pelvis (renal pelvis carcinoma).  The vast majority of renal cell carcinomas are adenocarcinomas.  The vast majority of renal pelvis carcinomas are transitional cell carcinomas.  Renal carcinomas usually affect middle aged and elderly adults.  Hematuria, abdominal pain, and a palpable mass are common symptoms. -- 2004
C9385	Renal_Cell_Carcinoma	Adenocarcinoma|Renal_Carcinoma	Renal Cell Carcinoma|Adenocarcinoma of Kidney|Adenocarcinoma of the Kidney|Kidney Adenocarcinoma|RCC|Renal Cell Adenocarcinoma|Renal Cell Cancer|Renal Cell Carcinoma, Stage Unspecified|renal cell cancer	Cancer that develops in the lining of the renal tubules, which filter the blood and produce urine.
C9387	Sarcoma_by_NCI_Grade	Sarcoma_of_the_Soft_Tissue_and_Bone	Sarcoma by NCI Grade|NCI Tumor Grade in Sarcoma
C9388	Sarcoma_NCI_Grade_1	Sarcoma_by_NCI_Grade	Sarcoma NCI Grade 1|Sarcoma NCI Grade I
C9389	Well_Differentiated_Leiomyosarcoma	Leiomyosarcoma|Sarcoma_Differentiation_Score_1|Sarcoma_NCI_Grade_1	Well Differentiated Leiomyosarcoma
C9390	Leiomyosarcoma_NCI_Grade_3	Leiomyosarcoma|Sarcoma_NCI_Grade_3	Leiomyosarcoma NCI Grade 3|Leiomyosarcoma NCI Grade III
C9391	Leiomyosarcoma_NCI_Grade_2	Leiomyosarcoma|Sarcoma_NCI_Grade_2	Leiomyosarcoma NCI Grade 2|Leiomyosarcoma NCI Grade II
C9392	Well_Differentiated_Malignant_Hemangiopericytoma	Malignant_Hemangiopericytoma	Well Differentiated Malignant Hemangiopericytoma
C9393	Malignant_Hemangiopericytoma_NCI_Grade_2	Malignant_Hemangiopericytoma|Sarcoma_NCI_Grade_2	Malignant Hemangiopericytoma NCI Grade 2|Malignant Hemangiopericytoma NCI Grade II
C9394	Malignant_Hemangiopericytoma_NCI_Grade_3	Malignant_Hemangiopericytoma|Sarcoma_NCI_Grade_3	Malignant Hemangiopericytoma NCI Grade 3|Malignant Hemangiopericytoma NCI Grade III
C9395	Chondrosarcoma_NCI_Grade_3	Chondrosarcoma|Sarcoma_NCI_Grade_3	Chondrosarcoma NCI Grade 3|Chondrosarcoma NCI Grade III
C9396	Chondrosarcoma_NCI_Grade_2	Chondrosarcoma|Sarcoma_NCI_Grade_2	Chondrosarcoma NCI Grade 2|Chondrosarcoma NCI Grade II
C9397	Chondrosarcoma_NCI_Grade_1	Chondrosarcoma|Sarcoma_NCI_Grade_1	Chondrosarcoma NCI Grade 1|Chondrosarcoma NCI Grade I
C9398	Myxoid_Chondrosarcoma_NCI_Grade_1	Chondrosarcoma_NCI_Grade_1|Myxoid_Chondrosarcoma	Myxoid Chondrosarcoma NCI Grade 1|Myxoid Chondrosarcoma NCI Grade I
C9399	Myxoid_Chondrosarcoma_NCI_Grade_2	Chondrosarcoma_NCI_Grade_2|Myxoid_Chondrosarcoma	Myxoid Chondrosarcoma NCI Grade 2|Myxoid Chondrosarcoma NCI Grade II
C9400	Sarcoma_NCI_Grade_2	Sarcoma_by_NCI_Grade	Sarcoma NCI Grade 2|Sarcoma NCI Grade II
C9401	Round_Cell_Liposarcoma_NCI_Grade_2	Round_Cell_Liposarcoma|Sarcoma_NCI_Grade_2	Round Cell Liposarcoma NCI Grade 2|Round Cell Liposarcoma NCI Grade II
C9402	Round_Cell_Liposarcoma_NCI_Grade_3	Round_Cell_Liposarcoma|Sarcoma_NCI_Grade_3	Round Cell Liposarcoma NCI Grade 3|Round Cell Liposarcoma NCI Grade III
C9403	Fibrosarcoma_NCI_Grade_2	Fibrosarcoma|Sarcoma_NCI_Grade_2	Fibrosarcoma NCI Grade 2|Fibrosarcoma NCI Grade II
C9404	Poorly_Differentiated_Fibrosarcoma	Fibrosarcoma|Sarcoma_Differentiation_Score_3|Sarcoma_NCI_Grade_3	Poorly Differentiated Fibrosarcoma
C9405	Storiform-Pleomorphic_Malignant_Fibrous_Histiocytoma_NCI_Grade_2	Sarcoma_NCI_Grade_2|Storiform-Pleomorphic_Malignant_Fibrous_Histiocytoma	Storiform-Pleomorphic Malignant Fibrous Histiocytoma NCI Grade 2|Storiform-Pleomorphic Malignant Fibrous Histiocytoma NCI Grade II
C9406	Storiform-Pleomorphic_Malignant_Fibrous_Histiocytoma_NCI_Grade_3	Sarcoma_NCI_Grade_3|Storiform-Pleomorphic_Malignant_Fibrous_Histiocytoma	Storiform-Pleomorphic Malignant Fibrous Histiocytoma NCI Grade 3|Storiform-Pleomorphic Malignant Fibrous Histiocytoma NCI Grade III
C9407	Inflammatory_Malignant_Fibrous_Histiocytoma_NCI_Grade_2	Inflammatory_Malignant_Fibrous_Histiocytoma|Sarcoma_NCI_Grade_2	Inflammatory Malignant Fibrous Histiocytoma NCI Grade 2|Inflammatory Malignant Fibrous Histiocytoma NCI Grade II
C9408	Inflammatory_Malignant_Fibrous_Histiocytoma_NCI_Grade_3	Inflammatory_Malignant_Fibrous_Histiocytoma|Sarcoma_NCI_Grade_3	Inflammatory Malignant Fibrous Histiocytoma NCI Grade 3|Inflammatory Malignant Fibrous Histiocytoma NCI Grade III
C9409	Epithelioid_Sarcoma_NCI_Grade_2	Epithelioid_Sarcoma|Sarcoma_NCI_Grade_2	Epithelioid Sarcoma NCI Grade 2|Epithelioid Sarcoma NCI Grade II
C9410	Epithelioid_Sarcoma_NCI_Grade_3	Epithelioid_Sarcoma|Sarcoma_NCI_Grade_3	Epithelioid Sarcoma NCI Grade 3|Epithelioid Sarcoma NCI Grade III
C9411	Angiosarcoma_NCI_Grade_2	Angiosarcoma|Sarcoma_NCI_Grade_2	Angiosarcoma NCI Grade 2|Angiosarcoma NCI Grade II
C9412	Angiosarcoma_NCI_Grade_3	Angiosarcoma|Sarcoma_NCI_Grade_3	Angiosarcoma NCI Grade 3|Angiosarcoma NCI Grade III
C9413	Kaposi_s_Sarcoma_NCI_Grade_2	Kaposi_s_Sarcoma|Sarcoma_NCI_Grade_2	Kaposi's Sarcoma NCI Grade 2|Kaposi's Sarcoma NCI Grade II
C9414	Kaposi_s_Sarcoma_NCI_Grade_3	Kaposi_s_Sarcoma|Sarcoma_NCI_Grade_3	Kaposi's Sarcoma NCI Grade 3|Kaposi's Sarcoma NCI Grade III
C9415	Sarcoma_NCI_Grade_3	Sarcoma_by_NCI_Grade	Sarcoma NCI Grade 3|Sarcoma NCI Grade III
C9416	Sarcoma_by_AJCC_Grade	Sarcoma_of_the_Soft_Tissue_and_Bone	Sarcoma by AJCC Grade|AJCC Tumor Grade in Sarcoma
C9417	Low-Grade_Sarcoma	Sarcoma_by_AJCC_Grade	Low Grade Sarcoma|Low-Grade Sarcoma|Well or Moderately Differentiated Sarcoma
C9418	High-Grade_Sarcoma	Sarcoma_by_AJCC_Grade	High Grade Sarcoma|High-Grade Sarcoma|Poorly Differentiated or Undifferentiated Sarcoma
C9419	AJCC_Grade_1_Sarcoma	Low-Grade_Sarcoma	AJCC Grade 1 Sarcoma|AJCC G1 Sarcoma|AJCC Grade I Sarcoma|Well Differentiated Sarcoma
C9420	AJCC_Grade_2_Sarcoma	Low-Grade_Sarcoma	AJCC Grade 2 Sarcoma|AJCC G2 Sarcoma|AJCC Grade II Sarcoma|Moderately Differentiated Sarcoma
C9421	AJCC_Grade_3_Sarcoma	High-Grade_Sarcoma	AJCC Grade 3 Sarcoma|AJCC G3 Sarcoma|AJCC Grade III Sarcoma
C9422	AJCC_Grade_4_Sarcoma	High-Grade_Sarcoma	AJCC Grade 4 Sarcoma|AJCC G4 Sarcoma|AJCC Grade IV Sarcoma
C9423	Mixed_Small_Cell_and_Squamous_Cell_Lung_Carcinoma	Combined_Type_Small_Cell_Lung_Carcinoma	Combined Small Cell and Squamous Cell Lung Carcinoma|Mixed Small Cell and Squamous Cell Carcinoma of Lung|Mixed Small Cell and Squamous Cell Carcinoma of the Lung|Small Cell and Squamous Cell Carcinoma of Lung|Small Cell and Squamous Cell Carcinoma of the Lung|Small Cell and Squamous Cell Lung Carcinoma	A lung carcinoma characterized by a combination of small cell carcinoma and squamous cell carcinoma. (NCI05)
C9424	Combined_Small_and_Large_Cell_Lung_Carcinoma	Retired_Concepts	Combined Small and Large Cell Lung Carcinoma|Combined Small Cell and Large Cell Lung Carcinoma|Combined Small and Large Cell Lung Cancer|Mixed Small Cell and Large Cell Carcinoma of Lung|Mixed Small Cell and Large Cell Carcinoma of the Lung|Mixed Small Cell and Large Cell Lung Carcinoma|Small Cell and Large Cell Carcinoma of Lung|Small Cell and Large Cell Carcinoma of the Lung|Small Cell and Large Cell Lung Carcinoma
C9425	Conventional_Malignant_Hemangiopericytoma	Malignant_Hemangiopericytoma|Sarcoma_Differentiation_Score_3	Conventional Malignant Hemangiopericytoma
C9426	Conventional_Angiosarcoma	Angiosarcoma|Sarcoma_Differentiation_Score_2	Conventional Angiosarcoma
C9428	Conventional_Leiomyosarcoma	Leiomyosarcoma|Sarcoma_Differentiation_Score_2	Conventional Leiomyosarcoma
C9429	Conventional_Fibrosarcoma	Fibrosarcoma|Sarcoma_Differentiation_Score_2	Conventional Fibrosarcoma
C9430	Pigmented_Dermatofibrosarcoma_Protuberans_Bednar_Tumor	Dermatofibrosarcoma_Protuberans	Pigmented Dermatofibrosarcoma Protuberans (Bednar Tumor)|Bednar Tumor|Pigmented Dermatofibrosarcoma Protuberans
C9431	Childhood_Hematopoietic_Neoplasm	Childhood_Neoplasm	Childhood Hematopoietic Neoplasm
C9432	Malignant_Pleural_Effusion	Pleural_Effusion	Malignant Pleural Effusion	A collection of fluid in the pleural cavity as a result of malignant disease. Malignant pleural effusion fluid often contains free-floating malignant cells. --2004
C9433	Talc_Granuloma	Foreign_Body_Granuloma	Talc Granuloma
C9434	Infectious_Granuloma	Granuloma	Infectious Granuloma
C9435	Granuloma_by_Site	Granuloma	Granuloma by Site
C9436	Radiation_Fibrosis	Pulmonary_Fibrosis	Radiation Fibrosis|radiation fibrosis	(ray-dee-AY-shun fye-BRO-sis) The formation of scar tissue as a result of radiation therapy.
C9438	Chronic_Renal_Failure	Renal_Failure	Chronic Renal Failure|Chronic Renal Disease	An irreversible and usually progressive reduction in renal function in which both kidneys have been damaged by a variety of diseases to the extent that they are unable to adequately remove the metabolic products from the blood and regulate the body's electrolyte composition and acid-base balance. (from MSH98)
C9439	End_Stage_Renal_Disease	Chronic_Renal_Failure	End Stage Renal Disease|ESRD	An irreversible and usually progressive reduction in renal function in which both kidneys have been damaged by a variety of diseases to the extent that they are unable to adequately remove the metabolic products from the blood and regulate the body's electrolyte composition and acid-base balance. (from MSH98)
C9440	Abnormality	Other_Finding	Abnormality|ABN|Anomaly	A condition that differs from the usual physical or mental state.
C9441	AML_MDS	Retired_Concepts	AML/MDS
C9442	Deposit	Morphologic_Finding	Deposit|DEPS|Deposits	Accumulation of extraneous inorganic matter in tissues or cavities.
C9443	Prior_Primary	Other_Finding	Prior Primary|PRIOR-PRM|Prior Primary Treatment	The term refers to the treatment that was performed in the effort to cure the neoplastic disease before (prior) the current or being currently planned treatment regimen or given clinical event. Primary treatment is usually surgery, chemotherapy, or radiation therapy, or combination of some or all modalities listed above.
C9445	Rupture	Injury	Rupture|RUPT	Forcible tearing or disruption of tissue.
C9446	Grade_I_Colorectal_Adenocarcinoma	Colorectal_Adenocarcinoma	Grade I Colorectal Adenocarcinoma|Low Grade Colorectal Adenocarcinoma|Well Differentiated Colorectal Adenocarcinoma
C9447	Grade_II_Colorectal_Adenocarcinoma	Colorectal_Adenocarcinoma	Grade II Colorectal Adenocarcinoma|Average Grade Colorectal Adenocarcinoma|Moderately Differentiated Colorectal Adenocarcinoma
C9448	Grade_III_Colorectal_Adenocarcinoma	Colorectal_Adenocarcinoma	Grade III Colorectal Adenocarcinoma|Poorly Differentiated Colorectal Adenocarcinoma
C9449	Grade_III_Rectal_Adenocarcinoma	Grade_III_Colorectal_Adenocarcinoma|Rectal_Adenocarcinoma	Grade III Rectal Adenocarcinoma|Poorly Differentiated Rectal Adenocarcinoma
C9450	Grade_II_Rectal_Adenocarcinoma	Grade_II_Colorectal_Adenocarcinoma|Rectal_Adenocarcinoma	Grade II Rectal Adenocarcinoma|Moderately Differentiated Rectal Adenocarcinoma
C9451	Grade_I_Rectal_Adenocarcinoma	Grade_I_Colorectal_Adenocarcinoma|Rectal_Adenocarcinoma	Grade I Rectal Adenocarcinoma|Well Differentiated Rectal Adenocarcinoma
C9452	Grade_I_Colon_Adenocarcinoma	Colon_Adenocarcinoma|Grade_I_Colorectal_Adenocarcinoma	Grade I Colon Adenocarcinoma|Well Differentiated Colon Adenocarcinoma
C9453	Grade_II_Colon_Adenocarcinoma	Colon_Adenocarcinoma|Grade_II_Colorectal_Adenocarcinoma	Grade II Colon Adenocarcinoma|Moderately Differentiated Colon Adenocarcinoma
C9454	Grade_III_Colon_Adenocarcinoma	Colon_Adenocarcinoma|Grade_III_Colorectal_Adenocarcinoma	Grade III Colon Adenocarcinoma|Poorly Differentiated Colon Adenocarcinoma
C9456	Intermediate-Grade_Ductal_Carcinoma_In_Situ_of_the_Breast	Ductal_Carcinoma_in_situ_of_the_Breast	Intermediate Grade Ductal Breast Carcinoma In Situ|DCIS Grade 2|DIN 2|Ductal Intraepithelial Neoplasia, Grade 2|Intermediate-Grade DCIS|Intermediate-Grade Ductal Carcinoma In Situ of Breast
C9457	Low-Grade_Ductal_Carcinoma_In_Situ_of_the_Breast	Ductal_Carcinoma_in_situ_of_the_Breast	Low Grade Ductal Breast Carcinoma In Situ|DCIS Grade 1|DIN 1C|Ductal Intraepithelial Neoplasia, Grade 1C|Low-Grade DCIS|Low-Grade Ductal Carcinoma In Situ of Breast
C9458	Proliferating_Brenner_Tumor	Borderline_Brenner_Tumor	Proliferating Ovarian Brenner Tumor|Proliferating Brenner Neoplasm of Ovary|Proliferating Brenner Neoplasm of the Ovary|Proliferating Brenner Tumor of Ovary|Proliferating Brenner Tumor of the Ovary|Proliferating Ovarian Brenner Neoplasm	Proliferating Brenner tumor is a Brenner tumor characterised by papillary fronds and nuclear cytologic atypia (pattern resembling that of a low-grade [grades I or II] transitional cell carcinoma of the urinary bladder). --2002
C9459	Borderline_Brenner_Tumor	Borderline_Ovarian_Transitional_Cell_Tumor|Brenner_Tumor_of_the_Ovary	Borderline Ovarian Brenner Tumor|Borderline Brenner Neoplasm of Ovary|Borderline Brenner Neoplasm of the Ovary|Borderline Brenner Tumor of Ovary|Borderline Brenner Tumor of the Ovary|Borderline Ovarian Brenner Neoplasm|Low Malignancy Potential Brenner Neoplasm of Ovary|Low Malignancy Potential Brenner Neoplasm of the Ovary|Low Malignancy Potential Brenner Tumor of Ovary|Low Malignancy Potential Brenner Tumor of the Ovary|Low Malignancy Potential Ovarian Brenner Neoplasm|Low Malignancy Potential Ovarian Brenner Tumor	Borderline Brenner tumor is a Brenner tumor characterised by papillary fronds and nuclear cytologic atypia (pattern resembling that of a grade III transitional cell carcinoma of the urinary bladder ) but stromal invasion cannot be demonstrated. --2002
C9460	Cockayne_Syndrome	Genetic_Disorder|Syndrome	Cockayne Syndrome|Cockayne syndrome	A genetic condition characterized by short stature, premature aging, sensitivity to light, and possibly deafness and mental retardation.
C9461	Bladder_Small_Cell_Neuroendocrine_Carcinoma	Bladder_Carcinoma|Small_Cell_Carcinoma	Bladder Small Cell/Neuroendocrine Carcinoma|Small Cell/Neuroendocrine Carcinoma of Urinary Bladder|Small Cell/Neuroendocrine Carcinoma of the Urinary Bladder	Highly aggressive carcinomas histologically resembling lung small cell lung carcinomas.  In most cases are associated with carcinoma in situ. --2002
C9462	Laryngeal_Adenoid_Cystic_Carcinoma	Adenoid_Cystic_Carcinoma|Laryngeal_Carcinoma	Laryngeal Adenoid Cystic Carcinoma|Adenoid Cystic Carcinoma of Larynx|Adenoid Cystic Carcinoma of the Larynx
C9463	Laryngeal_Mucoepidermoid_Carcinoma	Laryngeal_Carcinoma|Mucoepidermoid_Carcinoma	Laryngeal Mucoepidermoid Carcinoma|Mucoepidermoid Carcinoma of Larynx|Mucoepidermoid Carcinoma of the Larynx
C9464	Grade_1_Diffuse_Follicle_Center_Lymphoma	Diffuse_Follicle_Center_Lymphoma	Grade 1 Diffuse Follicle Centre Lymphoma
C9465	Hypopharyngeal_Carcinoma	Malignant_Hypopharyngeal_Neoplasm|Pharyngeal_Carcinoma	Hypopharyngeal Carcinoma|Cancer of Hypopharynx|Cancer of the Hypopharynx|Carcinoma of Hypopharynx|Carcinoma of the Hypopharynx|Hypopharyngeal Cancer	Carcinoma, predominantly squamous cell, arising from epithelial cells of the hypopharynx. -- 2004
C9466	Pharyngeal_Carcinoma	Malignant_Pharyngeal_Neoplasm|Throat_Cancer	Pharyngeal Carcinoma|Cancer of Pharynx|Cancer of the Pharynx|Carcinoma of Pharynx|Carcinoma of the Pharynx|Pharyngeal Cancer|Pharynx Carcinoma	Carcinoma, predominantly squamous cell, arising from epithelial cells of the pharynx. -- 2004
C9467	Chronic_Cancer_Pain	Chronic_Pain	Chronic Cancer Pain
C9468	C3_Deficiency	Complement_Deficiency	C3 Deficiency
C9469	C5_Deficiency	Complement_Deficiency	C5 Deficiency
C9470	Systemic_Anaplastic_Large_Cell_Lymphoma	Anaplastic_Large_Cell_Lymphoma	Systemic Anaplastic Large Cell Lymphoma
C9471	Childhood_Systemic_Anaplastic_Large_Cell_Lymphoma	Childhood_Anaplastic_Large_Cell_Lymphoma|Systemic_Anaplastic_Large_Cell_Lymphoma	Childhood Systemic Anaplastic Large Cell Lymphoma|Childhood Systemic CD30+ Anaplastic Large Cell Lymphoma|Childhood Systemic K-1+ Anaplastic Large Cell Lymphoma|Pediatric Systemic Anaplastic Large Cell Lymphoma|Pediatric Systemic CD30+ Anaplastic Large Cell Lymphoma|Pediatric Systemic K-1+ Anaplastic Large Cell Lymphoma
C9472	Atypical_Gastric_Lymphoid_Hyperplasia	Atypical_Lymphoproliferative_Disorder|Gastric_Precancerous_Condition	Atypical Gastric Lymphoid Hyperplasia|Atypical Gastric Lymphoid Hyperplasia of Stomach|Atypical Gastric Lymphoid Hyperplasia of the Stomach
C9473	Lactating_Adenoma	Breast_Adenoma	Lactating Adenoma|Pregnancy Adenoma
C9474	Mullerian_Adenosarcoma	Malignant_Mixed_Neoplasm|Mixed_Mesodermal_Mullerian_Tumor	Adenosarcoma|Mullerian Adenosarcoma
C9475	Cerebellar_Astrocytoma	Astrocytic_Tumor	Cerebellar Astrocytoma|Astrocytic Neoplasm of Cerebellum|Astrocytic Neoplasm of the Cerebellum|Astrocytic Tumor of Cerebellum|Astrocytic Tumor of the Cerebellum|Astrocytoma of Cerebellum|Astrocytoma of the Cerebellum|Astrocytoma, Cerebellar|Cerebellar Astrocytic Neoplasm|Cerebellar Astrocytic Tumor	Benign and malignant neoplasms of the cerebellum that arise from astrocytes.  During childhood the majority are benign pilocytic astrocytomas.  In adults both benign and relatively higher grade forms may occur. The most common presenting symptoms are headache, nausea, vomiting, ataxia of gait or limb, paresis, diplopia, and dizziness. Objective signs include weakness, long tract signs, dysmetria, gait ataxia, papilledema, and nystagmus.  Surgical resection is often curative. (KEV 8-7-99)
C9476	Desmoplastic_Infantile_Astrocytoma	Benign_Childhood_Cerebral_Neoplasm|Neuronal_and_Mixed_Neuronal-Glial_Tumor	Desmoplastic Infantile Astrocytoma|DIA|Desmoplastic Astrocytoma of Infancy	A WHO grade I large cystic tumor that occurs almost exclusively in infants, with a prominent desmoplastic stroma having a neuroepithelial population mainly of neoplastic astrocytes. They involve the superficial cerebral cortex and leptomeninges, and often attach to the dura. Although clinically they present as large tumors, they generally have a good prognosis following surgical resection. (Adapted from WHO 2000.) - 2004
C9477	Anaplastic_Astrocytoma	Anaplastic_Malignant_Neoplasm|Astrocytic_Tumor|Malignant_Glioma	Anaplastic Astrocytoma|Anaplastic Astrocytic Neoplasm|Anaplastic Astrocytic Tumor|Grade III Astrocytic Neoplasm|Grade III Astrocytic Tumor|Grade III Astrocytoma|Malignant Astrocytoma	Anaplastic astrocytoma, which corresponds to WHO grade III, is a diffusely infiltrating astrocytoma with focal or dispersed anaplasia, and a marked proliferative potential. Anaplastic astrocytomas arise from low-grade astrocytomas, but are also diagnosed at first biopsy, without indication of a less malignant precursor lesion. They have an intrinsic tendency for malignant progression to glioblastoma. (WHO)
C9478	Atypia	Morphologic_Finding	Atypia
C9479	Familial_Cancer	Malignant_Neoplasm	Hereditary Malignant Neoplasm|Familial Cancer|Familiar Malignant Neoplasm|Hereditary Cancer|familial cancer	Cancer aggregating among blood relatives.  Does not necessarily imply a genetic inheritance.
C9480	Invasive_Carcinoma	Carcinoma	Invasive Carcinoma
C9481	Primary_Carcinoma	Carcinoma	Primary Carcinoma
C9482	Extraskeletal_Chondroma	Benign_Extraskeletal_Cartilaginous_and_Osseous_Neoplasm|Enchondroma	Extraskeletal Chondroma
C9483	Pineal_Gland_Cyst	Central_Nervous_System_Cyst	Pineal Gland Cyst|Cyst of Pineal Gland|Cyst of the Pineal Gland|Pineal Cyst	A fluid filled sac within the pineal gland. It is usually an incidental finding of no real clinical significance.
C9484	Chromosomal_Deletion	Structural_Chromosomal_Abnormality	Chromosomal Deletion|Partial Monosomy|del	Loss of a portion of a chromosome arm.
C9486	Anosognostic_Epilepsy	Epilepsy	Anosognostic Epilepsy
C9487	Intractable_Epilepsy	Epilepsy	Intractable Epilepsy
C9489	Genitourinary_Fistula	Fistula	Genitourinary Fistula|Urogenital Fistula
C9490	Sarcoidal_Granuloma	Granuloma	Sarcoidal Granuloma
C9491	Schistosome_Granuloma	Infectious_Granuloma	Schistosome Granuloma
C9492	Ductal_Breast_Hyperplasia	Breast_Hyperplasia|Intraductal_Hyperplasia	Ductal Breast Hyperplasia|Breast Epithelial Hyperplasia|Ductal Hyperplasia of Breast|Ductal Hyperplasia of the Breast|Epithelial Hyperplasia of Breast|Epithelial Hyperplasia of the Breast
C9493	Hypochondria	Psychiatric_Disorder	Hypochondriasis|Hypochondria
C9494	Latent_Infection	Infectious_Disorder	Latent Infection	A period in which the infection is present in the host without producing overt symptoms.  (from Online Medical Dictionary)
C9495	Radial_Scar	Breast_Fibrocystic_Change_Proliferative_Type|Non-Neoplastic_Breast_Disorder	Radial Scar|Complex Sclerosing Lesion|Radial Scar/Complex Sclerosing Lesion|Radial Sclerosing Lesion
C9496	T-Cell_Histiocyte_Rich_Lymphoma	Diffuse_Large_B-Cell_Lymphoma	T-Cell/Histiocyte Rich Lymphoma|T-Cell Rich/Histiocyte-Rich Large B-Cell Lymphoma
C9497	Melanotic_Medulloblastoma	Medulloblastoma	Melanotic Medulloblastoma	Melanotic Medulloblastoma (WHO grade IV) is a rare tumor of childhood with a predominant element of small round cells closely resembling classic medulloblastoma and a minor component of melanin-forming neuroepithelial cells. (Adapted from WHO.)
C9498	Melanocytoma	Melanocytic_Neoplasm	Melanocytoma
C9499	Melanomatosis	Melanocytic_Neoplasm	Melanomatosis
C9501	Micrometastasis	Retired_Concepts	Micrometastasis	Small numbers of cancer cells that have spread from the primary tumor to other parts of the body and are too few to be picked up in a screening or diagnostic test.
C9502	Myolipoma	Benign_Lipomatous_Neoplasm	Myolipoma
C9503	Juvenile_Breast_Papillomatosis	Breast_Papillomatosis	Juvenile Breast Papillomatosis|Juvenile Papillomatosis of Breast|Juvenile Papillomatosis of the Breast
C9504	Stage_IVS_Neuroblastoma	Stage_IV_Neuroblastoma	Stage IVS Neuroblastoma|Neuroblastoma Stage IVS|Pepper's Syndrome
C9505	Dysembryoplastic_Neuroepithelial_Tumor	Childhood_Central_Nervous_System_Neoplasm|Neuronal_and_Mixed_Neuronal-Glial_Tumor	Dysembryoplastic Neuroepithelial Tumor|DNET|DNT|Dysembryoplastic Neuroepithelial Neoplasm	Dysembryoplastic Neuroepithelial Tumor (WHO grade I) is a benign glial-neuronal neoplasm. It is usually supratentorial, located, generally, in the cortex and occurs in children and young adults with a long-standing history of partial seizures. A histologic hallmark of this tumor is the 'specific glioneuronal element', characterized by columns, made up of bundles of axons, oriented perpendicularly to the cortical surface. (Adapted from WHO.)
C9506	Tegafur_Uracil	Thymidylate_Synthase_Inhibitor	UFT|Tegafur-Uracil|Uftoral|Uracil and Ftorafur|Uracil and Tegafur|Uracil and Tetrahydrofuranyl-5-Fluorouracil|Uracil/Tegafur (UFT)	A formulated therapeutic oral agent consisting of a combination of a 5-fluorouracil (5-FU) congener and uracil (1:4). Because of its higher concentration in the combination, uracil saturates the uracil-reducing enzymatic activity of dihydropyrimidine dehydrogenase, thereby inhibiting first-pass dihydropyrimidine dehydrogenase-mediated hepatic metabolism of the uracil analogue 5-FU and permitting oral administration of 5-FU. 5-FU inhibits the enzyme thymidylate synthase, resulting in decreased thymidine synthesis and so reduced DNA synthesis and tumor cell cytotoxicity. (NCI04)
C9507	Cytarabine_Doxorubicin	Chemotherapy_Regimen	Cytarabine/Doxorubicin|ARA-C/DOX
C9508	Bleomycin_Dacarbazine_Doxorubicin_Vincristine	Chemotherapy_Regimen	Bleomycin/Dacarbazine/Doxorubicin/Vincristine|BLEO/DOX/DTIC/VCR
C9509	Bleomycin_Dacarbazine_Doxorubicin_Vinblastine	Chemotherapy_Regimen	Bleomycin/Dacarbazine/Doxorubicin/Vinblastine|ABDV|ABVD|BLEO/DOX/DTIC/VBL
C9510	Cyclophosphamide_Doxorubicin	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin|ACe|CA|CTX/DOX|Doxorubicin/Cyclophosphamide
C9511	Cyclophosphamide_Dactinomycin_Fluorouracil	Chemotherapy_Regimen	Cyclophosphamide/Dactinomycin/Fluorouracil|ACFUCY|CTX/DACT/5-FU
C9512	Melphalan_Thiotepa	Chemotherapy_Regimen	Melphalan/Thiotepa|L-PAM/TSPA|MELT
C9513	Dacarbazine_Doxorubicin	Chemotherapy_Regimen	Dacarbazine/Doxorubicin|DOX/DTIC|Doxorubicin/Dacarbazine
C9514	Cytarabine_Doxorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Cytarabine/Doxorubicin/Prednisone/Vincristine|ARA-C/DOX/PRED/VCR|HOAP|POCA
C9515	Doxorubicin_Fluorouracil_Methotrexate	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Methotrexate|DOX/5-FU/MTX|FAMTX
C9516	Amsacrine_Cytarabine_Prednisone_Vincristine	Chemotherapy_Regimen	Amsacrine/Cytarabine/Prednisone/Vincristine|AMSA-OAP|AMSA/ARA-C/PRED/VCR
C9517	Cyclophosphamide_Doxorubicin_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Methotrexate/Vincristine|AMCO|CODOX-M|CTX/DOX/MTX/VCR|LOMAC|MACO
C9518	Cisplatin_Doxorubicin_Vindesine	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Vindesine|CDDP/DAVA/DOX|VAP
C9519	Amsacrine_Cytarabine_Thioguanine	Chemotherapy_Regimen	Amsacrine/Cytarabine/Thioguanine|AAT|AMSA/ARA-C/TG
C9520	Doxorubicin_Mitomycin_Vinblastine	Chemotherapy_Regimen	Doxorubicin/Mitomycin/Vinblastine|DOX/MITO/VBL|MVA
C9521	Bleomycin_Dacarbazine_Doxorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Bleomycin/Dacarbazine/Doxorubicin/Prednisone/Vincristine|BAVIP|BLEO/DOX/DTIC/PRED/VCR
C9522	Bleomycin_Doxorubicin_Lomustine_Mechlorethamine_Vincristine	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Lomustine/Mechlorethamine/Vincristine|BACON|BLEO/CCNU/DOX/NM/VCR
C9523	Bleomycin_Cyclophosphamide_Dactinomycin	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Dactinomycin|BCD|BLEO/CTX/DACT
C9524	Carmustine_Cyclophosphamide_Prednisone	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Prednisone|BCNU/CTX/PRED|BCP
C9525	Carmustine_Cyclophosphamide_Prednisone_Vincristine	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Prednisone/Vincristine|BCNU/CTX/PRED/VCR|BCVP
C9526	Bleomycin_Cisplatin_Etoposide	Chemotherapy_Regimen	Bleomycin/Cisplatin/Etoposide|BLEO/CDDP/VP-16|PEB|PVP-16B
C9527	Cyclophosphamide_Cytarabine_Doxorubicin_Methotrexate_Prednisone_Thioguanine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Doxorubicin/Methotrexate/Prednisone/Thioguanine/Vincristine|ARA-C/CTX/DOX/MTX/PRED/TG/VCR
C9528	Bleomycin_Cisplatin_Ifosfamide	Chemotherapy_Regimen	Bleomycin/Cisplatin/Ifosfamide|BLEO/CDDP/IFF
C9529	Bleomycin_Cisplatin_Mitomycin_Vincristine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Mitomycin/Vincristine|BLEO/CDDP/MITO/VCR|BOMP|POMB
C9530	Carmustine_Cyclophosphamide_Prednisone_Procarbazine_Vinblastine	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Prednisone/Procarbazine/Vinblastine|BCNU/CTX/PCB/PRED/VBL|BCVPP|BVCPP
C9531	Lomustine_Methotrexate_Procarbazine	Chemotherapy_Regimen	Lomustine/Methotrexate/Procarbazine|CCNU/MTX/PCB|CMP
C9532	Carboplatin_Cyclophosphamide	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide|CBDCA/CTX|CBDCA/Cyclophosphamide
C9533	Cyclophosphamide_Doxorubicin_Fluorouracil	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil|CAF|CAFFI|CDF|CTX/DOX/5-FU|FAC
C9534	Cyclophosphamide_Doxorubicin_Fluorouracil_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Prednisone/Vincristine|CAFVP|CTX/DOX/5-FU/PRED/VCR
C9535	Cyclophosphamide_Doxorubicin_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Methotrexate|CAM|CTX/DOX/MTX
C9536	Cyclophosphamide_Doxorubicin_Etoposide_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Methotrexate/Vincristine|CTX/DOX/MTX/VCR/VP-16|VMV-VAC
C9537	Cyclophosphamide_Doxorubicin_Fluorouracil_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Methotrexate|CTX/DOX/5-FU/MTX|FAC-M
C9538	Cyclophosphamide_Doxorubicin_Methotrexate_Procarbazine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Methotrexate/Procarbazine|CAMP|CAMP Protocol|CTX/DOX/MTX/PCB	A combination antineoplastic therapy.
C9539	Cisplatin_Cyclophosphamide_Doxorubicin_Fluorouracil	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Fluorouracil|CDDP/CTX/DOX/5-FU|FACP
C9540	Cyclophosphamide_Doxorubicin_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Vincristine|ACO|CDV|CHO|CTX/DOX/VCR|CVA|OCA|VA-C|VAC|VADRC
C9541	Carmustine_Cyclophosphamide_Etoposide	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Etoposide|BCNU/CTX/VP-16|CBV
C9542	Cyclophosphamide_Lomustine_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Lomustine/Methotrexate/Vincristine|CCNU/CTX/MTX/VCR|CyMOC
C9543	Cyclophosphamide_Lomustine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Lomustine/Vincristine|CCNU/CTX/VCR|CCV
C9544	Cyclophosphamide_Doxorubicin_Lomustine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Lomustine/Vincristine|CCNU/CTX/DOX/VCR|CVAC
C9545	Cisplatin_Cyclophosphamide_Epirubicin	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Epirubicin|CDDP/CTX/EPI
C9546	Cyclophosphamide_Epirubicin_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Epirubicin/Vincristine|CTX/EPI/VCR
C9547	Cyclophosphamide_Fluorouracil	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil|CTX/5-FU
C9548	Cyclophosphamide_Fluorouracil_Prednisone	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Prednisone|CFP|CTX/5-FU/PRED
C9549	Cyclophosphamide_Doxorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Prednisone/Vincristine|ACOP|CAVP|CHOP|COPA|CTX/DOX/PRED/VCR|VACP|VCAP	A first-generation combination chemotherapy comprised of the drugs cyclophosphamide (C), hydroxydaunomycin (H), vincristine (O), and prednisone or its active metabolite prednisolone (P). (NCI04)
C9550	Bleomycin_Cyclophosphamide_Doxorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Doxorubicin/Prednisone/Vincristine|BACOP|BLEO/CTX/DOX/PRED/VCR|CA-BOP|CAVPB
C9551	Cyclophosphamide_Doxorubicin_Prednisone_Teniposide	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Prednisone/Teniposide|CHVP|CTX/DOX/PRED/VM-26
C9552	Cisplatin_Fluorouracil_Methotrexate	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Methotrexate|CDDP/5-FU/MTX
C9553	Bleomycin_Cyclophosphamide_Fluorouracil_Methotrexate	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Fluorouracil/Methotrexate|BLEO/CTX/5-FU/MTX|CMF-BLEO
C9554	Cyclophosphamide_Doxorubicin_Fluorouracil_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Methotrexate/Vincristine|CTX/DOX/5-FU/MTX/VCR|VAFMC
C9555	Cyclophosphamide_Fluorouracil_Methotrexate_Prednisone	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Methotrexate/Prednisone|CMFP|CTX/5-FU/MTX/PRED
C9556	Cyclophosphamide_Fluorouracil_Methotrexate_Prednisone_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Methotrexate/Prednisone/Tamoxifen|CMFPT|CTX/5-FU/MTX/PRED/TMX
C9557	Cyclophosphamide_Fluorouracil_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Methotrexate/Prednisone/Vincristine|CFPMV|CMFVP|CTX/5-FU/MTX/PRED/VCR|VPCMF
C9558	Cyclophosphamide_Cytarabine_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Prednisone/Vincristine|ARA-C/CTX/PRED/VCR|VPCA
C9559	Bleomycin_Cisplatin_Vincristine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Vincristine|BLEO/CDDP/VCR|COB
C9560	Cyclophosphamide_Fluorouracil_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Vincristine|CTX/5-FU/VCR|VCF
C9561	Cyclophosphamide_Fluorouracil_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Methotrexate/Vincristine|COMF|CTX/5-FU/MTX/VCR
C9562	Cyclophosphamide_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Methotrexate/Prednisone/Vincristine|CTX/MTX/PRED/VCR|M-COP
C9563	Bleomycin_Cyclophosphamide_Prednisone_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Prednisone/Vincristine|BLEO/CTX/PRED/VCR|COP-BLEO|COPB
C9564	Bleomycin_Cyclophosphamide_Doxorubicin_Prednisone_Procarbazine_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Doxorubicin/Prednisone/Procarbazine/Vincristine|BLEO/CTX/DOX/PCB/PRED/VCR|CAP-BOP
C9565	Cisplatin_Cyclophosphamide_Doxorubicin_Lomustine_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Lomustine/Vincristine|CCNU/CDDP/CTX/DOX/VCR|PACCO
C9566	Asparaginase_Cyclophosphamide_Cytarabine_Doxorubicin_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Doxorubicin/Methotrexate/Prednisone/Vincristine|ARA-C/ASP/CTX/DOX/MTX/PRED/VCR|CHOP-AMA
C9567	Cyclophosphamide_Prednisone_Procarbazine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Prednisone/Procarbazine/Vincristine|COPP|CTX/PCB/PRED/VCR
C9568	Cytarabine_Hydrocortisone	Chemotherapy_Regimen	Cytarabine/Hydrocortisone|ARA-C/HC
C9569	Cisplatin_Cyclophosphamide	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide|CD|CDDP/CTX|PC
C9570	Altretamine_Cisplatin_Cyclophosphamide_Doxorubicin	Chemotherapy_Regimen	Altretamine/Cisplatin/Cyclophosphamide/Doxorubicin|CDDP/CTX/DOX/HMM|CHAP-5|HCAP|HEXA-CAP
C9571	Bleomycin_Cisplatin_Vindesine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Vindesine|BLEO/CDDP/DAVA|DVB
C9572	Cyclophosphamide_Dacarbazine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dacarbazine/Vincristine|CDV|CTX/DTIC/VCR
C9573	Cyclophosphamide_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Prednisone/Vincristine|CTX/PRED/VCR|CVP|VCP
C9574	Cyclophosphamide_Prednisone_Procarbazine_Vinblastine	Chemotherapy_Regimen	Cyclophosphamide/Prednisone/Procarbazine/Vinblastine|CTX/PCB/PRED/VBL|CVPP
C9575	Lomustine_Prednisone_Procarbazine_Vinblastine	Chemotherapy_Regimen	Lomustine/Prednisone/Procarbazine/Vinblastine|CCNU/PCB/PRED/VBL|CVPP
C9576	Cyclophosphamide_Dacarbazine_Doxorubicin_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dacarbazine/Doxorubicin/Vincristine|CTX/DOX/DTIC/VCR|CY-VA-DIC|VAdrC-D
C9577	Cytarabine_Daunorubicin_Thioguanine	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Thioguanine|ARA-C/DNR/TG|TAD
C9578	Cytarabine_Daunorubicin_Prednisone_Thioguanine_Vincristine	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Prednisone/Thioguanine/Vincristine|ARA-C/DNR/PRED/TG/VCR|DATVP
C9579	Cytarabine_Daunorubicin_Etoposide	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Etoposide|ADE|ARA-C/DNR/VP-16
C9580	Doxorubicin_Fluoxymesterone_Mitolactol_Vincristine	Chemotherapy_Regimen	Doxorubicin/Fluoxymesterone/Mitolactol/Vincristine|DAVCH|DBD/DOX/FXM/VCR
C9581	Cytarabine_Daunorubicin_Mercaptopurine_Prednisolone	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Mercaptopurine/Prednisolone|ARA-C/DNR/MP/PRDL|DCMP
C9582	Bleomycin_Cisplatin	Chemotherapy_Regimen	Bleomycin/Cisplatin|BLEO/CDDP|BP
C9583	Cisplatin_Cytarabine_Dexamethasone	Chemotherapy_Regimen	Cisplatin/Cytarabine/Dexamethasone|ARA-C/CDDP/DM|DHAP
C9584	Doxorubicin_Procarbazine_Prednisone_Vincristine	Chemotherapy_Regimen	Doxorubicin/Procarbazine/Prednisone/Vincristine|DOX/PCB/PRED/VCR
C9585	Cisplatin_Doxorubicin_Etoposide	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Etoposide|CDDP/DOX/VP-16|PAV
C9586	Carmustine_Doxorubicin_Prednisone_Vindesine	Chemotherapy_Regimen	Carmustine/Doxorubicin/Prednisone/Vindesine|BCNU/DAVA/DOX/PRED|EBAP
C9587	Bleomycin_Epirubicin_Prednisone_Vinblastine	Chemotherapy_Regimen	Bleomycin/Epirubicin/Prednisone/Vinblastine|BLEO/EPI/PRED/VBL
C9588	Cyclophosphamide_Doxorubicin_Etoposide_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Vincristine|CAPO|CAVE|CTX/DOX/VCR/VP-16|EVAC|VCAV|VOCA
C9589	Cisplatin_Cytarabine_Dexamethasone_Etoposide	Chemotherapy_Regimen	Cisplatin/Cytarabine/Dexamethasone/Etoposide|ARA-C/CDDP/DM/VP-16|E-DHAP
C9590	Carmustine_Doxorubicin_Fluorouracil	Chemotherapy_Regimen	Carmustine/Doxorubicin/Fluorouracil|BCNU/DOX/5-FU|FAB
C9591	Cisplatin_Cyclophosphamide_Doxorubicin_Tegafur	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Tegafur|CDDP/CTX/DOX/FT
C9592	Doxorubicin_Fluorouracil_Mitomycin	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Mitomycin|DMF|DOX/5-FU/MITO|MIFA
C9593	Cisplatin_Doxorubicin_Fluorouracil_Mitomycin	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Fluorouracil/Mitomycin|CDDP/DOX/5-FU/MITO|FAMP
C9594	Cisplatin_Doxorubicin_Fluorouracil	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Fluorouracil|CDDP/DOX/5-FU|FAP
C9595	Cyclophosphamide_Epirubicin_Fluorouracil	Chemotherapy_Regimen	Cyclophosphamide/Epirubicin/Fluorouracil|CEF|CTX/EPI/5-FU|FEC|FEC 100
C9596	Fluorouracil_Mitomycin_Vincristine	Chemotherapy_Regimen	Fluorouracil/Mitomycin/Vincristine|5-FU/MITO/VCR|FOM
C9597	Altretamine_Cisplatin_Doxorubicin	Chemotherapy_Regimen	Altretamine/Cisplatin/Doxorubicin|CDDP/DOX/HMM|HAD
C9598	Altretamine_Cyclophosphamide_Fluorouracil_Methotrexate	Chemotherapy_Regimen	Altretamine/Cyclophosphamide/Fluorouracil/Methotrexate|CTX/5-FU/HMM/MTX|HEXA-CAF
C9599	Bleomycin_Cytarabine_Doxorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Bleomycin/Cytarabine/Doxorubicin/Prednisone/Vincristine|ARA-C/BLEO/DOX/PRED/VCR|HOAP-BLEO
C9600	Cisplatin_Doxorubicin_Ifosfamide	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Ifosfamide|CDDP/DOX/IFF|PIA
C9601	Etoposide_Ifosfamide_Methotrexate	Chemotherapy_Regimen	Etoposide/Ifosfamide/Methotrexate|IFF/MTX/VP-16|IMVP-16
C9602	Chlorambucil_Fluorouracil_Methotrexate	Chemotherapy_Regimen	Chlorambucil/Fluorouracil/Methotrexate|CLB/5-FU/MTX|LMF
C9603	Carmustine_Cyclophosphamide_Melphalan_Prednisone_Vincristine	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Melphalan/Prednisone/Vincristine|BCNU/CTX/L-PAM/PRED/VCR|VBMCP
C9604	Cisplatin_Doxorubicin_Methotrexate_Vinblastine	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Methotrexate/Vinblastine|CDDP/DOX/MTX/VBL|MVAC
C9605	Cisplatin_Epirubicin_Methotrexate_Vinblastine	Chemotherapy_Regimen	Cisplatin/Epirubicin/Methotrexate/Vinblastine|CDDP/EPI/MTX/VBL
C9606	Cyclophosphamide_Dactinomycin_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Dactinomycin/Methotrexate|CTX/DACT/MTX|MAC
C9607	Cyclophosphamide_Doxorubicin_Lomustine_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Lomustine/Methotrexate|CCNU/CTX/DOX/MTX|MACC
C9608	Cisplatin_Doxorubicin_Mitomycin	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Mitomycin|CDDP/DOX/MITO
C9609	Bleomycin_Cisplatin_Methotrexate	Chemotherapy_Regimen	Bleomycin/Cisplatin/Methotrexate|BLEO/CDDP/MTX|PBM
C9610	Cyclophosphamide_Lomustine_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Lomustine/Methotrexate|CCNU/CTX/MTX|CMC|CMCC
C9611	Altretamine_Cisplatin_Etoposide_Mitomycin	Chemotherapy_Regimen	Altretamine/Cisplatin/Etoposide/Mitomycin|CDDP/HMM/MITO/VP-16|MEPH
C9612	Cyclophosphamide_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Methotrexate/Vincristine|COM|CTX/MTX/VCR
C9613	Cyclophosphamide_Doxorubicin_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Methotrexate/Prednisone/Vincristine|CTX/DOX/MTX/PRED/VCR
C9614	Fluorouracil_Leucovorin-Calcium_Methotrexate	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Methotrexate|CF/5-FU/MTX|MLF
C9615	Etoposide_Ifosfamide_Methotrexate_Mitoguazone	Chemotherapy_Regimen	Etoposide/Ifosfamide/Methotrexate/Mitoguazone|IFF/MGBG/MTX/VP-16|MIME
C9616	Fluorouracil_Semustine_Vincristine	Chemotherapy_Regimen	Fluorouracil/Semustine/Vincristine|5-FU/MeCCNU/VCR|MOF
C9617	Fluorouracil_Semustine_Streptozocin_Vincristine	Chemotherapy_Regimen	Fluorouracil/Semustine/Streptozocin/Vincristine|5-FU/MeCCNU/SZC/VCR|MOF-STREP
C9618	Mechlorethamine_Procarbazine_Vincristine	Chemotherapy_Regimen	Mechlorethamine/Procarbazine/Vincristine|MOP|NM/PCB/VCR
C9619	Mechlorethamine_Prednisone_Procarbazine_Vincristine	Chemotherapy_Regimen	Mechlorethamine/Prednisone/Procarbazine/Vincristine|MOPP|NM/PCB/PRED/VCR
C9620	Bleomycin_Doxorubicin_Mechlorethamine_Prednisone_Procarbazine_Vinblastine_Vincristine	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Mechlorethamine/Prednisone/Procarbazine/Vinblastine/Vincristine|BLEO/DOX/NM/PCB/PRED/VBL/VCR|MOPP/ABV-Hybrid
C9621	Cyclophosphamide_Cytarabine_Doxorubicin_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Doxorubicin/Methotrexate/Vincristine|ARA-C/CTX/DOX/MTX/VCR|COMA-A
C9622	Mechlorethamine_Prednisone_Procarbazine_Vinblastine_Vincristine	Chemotherapy_Regimen	Mechlorethamine/Prednisone/Procarbazine/Vinblastine/Vincristine|MVVPP|NM/PCB/PRED/VBL/VCR
C9623	Cytarabine_Mitoxantrone	Chemotherapy_Regimen	Cytarabine/Mitoxantrone|ARA-C/DHAD|S-HAM
C9624	Cytarabine_Prednisone_Vincristine	Chemotherapy_Regimen	Cytarabine/Prednisone/Vincristine|ARA-C/PRED/VCR|OAP
C9625	Cyclophosphamide_Doxorubicin_Prednisone_Procarbazine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Prednisone/Procarbazine/Vincristine|ACOPP|CTX/DOX/PCB/PRED/VCR
C9626	Bleomycin_Cisplatin_Cyclophosphamide_Doxorubicin	Chemotherapy_Regimen	Bleomycin/Cisplatin/Cyclophosphamide/Doxorubicin|BCAP|BLEO/CDDP/CTX/DOX
C9627	Lomustine_Procarbazine_Vincristine	Chemotherapy_Regimen	Lomustine/Procarbazine/Vincristine|CCNU/PCB/VCR|PCV
C9628	Cisplatin_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Leucovorin Calcium|CDDP/CF/5-FU
C9629	Cyclophosphamide_Lomustine_Procarbazine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Lomustine/Procarbazine/Vincristine|CCNU/CTX/PCB/VCR|POCC
C9630	Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Mercaptopurine/Methotrexate/Prednisone/Vincristine|MMVP|MP/MTX/PRED/VCR|POMP-24
C9631	Ifosfamide_Methotrexate_Procarbazine	Chemotherapy_Regimen	Ifosfamide/Methotrexate/Procarbazine|IFF/MTX/PCB|PRIME
C9632	Bleomycin_Cyclophosphamide_Cytarabine_Doxorubicin_Etoposide_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Cytarabine/Doxorubicin/Etoposide/Methotrexate/Prednisone/Vincristine|ARA-C/BLEO/CTX/DOX/MTX/PRED/VCR/VP-16|PROMACE-CytaBOM|ProMACE/Cytabom
C9633	Bleomycin_Cisplatin_Vinblastine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Vinblastine|BLEO/CDDP/VBL|CVB|VBD|VBP
C9634	Asparaginase_Daunorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Daunorubicin/Prednisone/Vincristine|ASP/DNR/PRED/VCR|DVLP|VPLD
C9635	Bleomycin_Cisplatin_Etoposide_Vinblastine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Etoposide/Vinblastine|BLEO/CDDP/VBL/VP-16|PVBV
C9636	Cytarabine_Daunorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Prednisone/Vincristine|ARA-C/DNR/PRED/VCR|DOAP
C9637	Bleomycin_Doxorubicin_Lomustine_Streptozocin	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Lomustine/Streptozocin|BLEO/CCNU/DOX/SZC|CABS|SCAB
C9638	Doxorubicin_Fluoxymesterone_Thiotepa_Vinblastine	Chemotherapy_Regimen	Doxorubicin/Fluoxymesterone/Thiotepa/Vinblastine|DOX/FXM/TSPA/VBL|TsAVbH|VATH
C9639	Bleomycin_Cisplatin_Dactinomycin_Vinblastine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Dactinomycin/Vinblastine|BLEO/CDDP/DACT/VBL|VAB-II
C9640	Bleomycin_Dactinomycin_Vinblastine	Chemotherapy_Regimen	Bleomycin/Dactinomycin/Vinblastine|BLEO/DACT/VBL|VAB
C9641	Bleomycin_Chlorambucil_Cisplatin_Cyclophosphamide_Dactinomycin_Vinblastine	Chemotherapy_Regimen	Bleomycin/Chlorambucil/Cisplatin/Cyclophosphamide/Dactinomycin/Vinblastine|BLEO/CDDP/CLB/CTX/DACT/VBL|VAB-III
C9642	Cyclophosphamide_Dactinomycin_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dactinomycin/Vincristine|CTX/DACT/VCR|VAC|VAC (CTX/DACT/VCR)
C9643	Cyclophosphamide_Dactinomycin_Doxorubicin_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dactinomycin/Doxorubicin/Vincristine|CTX/DACT/DOX/VCR|CY-VA-DACT|VACA
C9644	Doxorubicin_Etoposide	Chemotherapy_Regimen	Doxorubicin/Etoposide|AVP-16|DOX/VP-16
C9645	Dexamethasone_Doxorubicin_Vincristine	Chemotherapy_Regimen	Dexamethasone/Doxorubicin/Vincristine|DM/DOX/VCR|VAD
C9646	Doxorubicin_Procarbazine_Vincristine	Chemotherapy_Regimen	Doxorubicin/Procarbazine/Vincristine|AVP|DOX/PCB/VCR
C9647	Doxorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Doxorubicin/Prednisone/Vincristine|APO|DOX/PRED/VCR|VAP
C9648	Cyclophosphamide_Doxorubicin_Prednisolone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Prednisolone/Vincristine|CTX/DOX/PRDL/VCR
C9649	Cyclophosphamide_Cytarabine_Doxorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Doxorubicin/Prednisone/Vincristine|ARA-C/CTX/DOX/PRED/VCR|POACH
C9650	Doxorubicin_Etoposide_Vincristine	Chemotherapy_Regimen	Doxorubicin/Etoposide/Vincristine|DOX/VCR/VP-16|VAV
C9651	Bleomycin_Doxorubicin_Vinblastine	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Vinblastine|ABV|BLEO/DOX/VBL
C9652	Carmustine_Dexamethasone_Doxorubicin_Melphalan_Vincristine	Chemotherapy_Regimen	Carmustine/Dexamethasone/Doxorubicin/Melphalan/Vincristine|BCNU/DM/DOX/L-PAM/VCR|VBAMDex
C9653	Carmustine_Doxorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Carmustine/Doxorubicin/Prednisone/Vincristine|BCNU/DOX/PRED/VCR
C9654	Bleomycin_Methotrexate_Vincristine	Chemotherapy_Regimen	Bleomycin/Methotrexate/Vincristine|ABO|BLEO/MTX/VCR|VBM-L
C9655	Cyclophosphamide_Prednisolone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Prednisolone/Vincristine|CTX/PRDL/VCR|PentaCOP
C9656	Daunorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Daunorubicin/Prednisone/Vincristine|DNR/PRED/VCR|DVP
C9657	Cisplatin_Interleukin-2	Chemotherapy_Regimen	Cisplatin/Interleukin-2|CDDP/IL-2
C9658	Cyclophosphamide_Doxorubicin_Methotrexate_Prednisolone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Methotrexate/Prednisolone/Vincristine|CTX/DOX/MTX/PRDL/VCR
C9659	Cisplatin_Etoposide_Ifosfamide	Chemotherapy_Regimen	Cisplatin/Etoposide/Ifosfamide|CDDP/IFF/VP-16|VIP
C9660	Bleomycin_Cisplatin_Methotrexate_Vincristine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Methotrexate/Vincristine|BLEO/CDDP/MTX/VCR|CABO
C9661	Cyclophosphamide_Melphalan_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Melphalan/Prednisone/Vincristine|CTX/L-PAM/PRED/VCR|VCMP
C9662	Fluorouracil_Methotrexate_Vincristine	Chemotherapy_Regimen	Fluorouracil/Methotrexate/Vincristine|5-FU/MTX/VCR|VMF
C9663	Etoposide_Methotrexate_Vincristine	Chemotherapy_Regimen	Etoposide/Methotrexate/Vincristine|MTX/VCR/VP-16|VMV
C9664	Prednisolone_Vincristine	Chemotherapy_Regimen	Prednisolone/Vincristine|PRDL/VCR|VP
C9665	Cisplatin_Etoposide	Chemotherapy_Regimen	Cisplatin/Etoposide|CDDP/VP-16|PE|PVp|VP-Plat|VPP
C9666	Bleomycin_Dacarbazine_Doxorubicin_Lomustine_Prednisone	Chemotherapy_Regimen	Bleomycin/Dacarbazine/Doxorubicin/Lomustine/Prednisone|AB-DIC|BLEO/CCNU/DOX/DTIC/PRED
C9667	Cyclophosphamide_Dexamethasone_Doxorubicin_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Doxorubicin/Vincristine|CHOD|CTX/DM/DOX/VCR
C9668	Fluorouracil_Mitomycin_Streptozocin	Chemotherapy_Regimen	Fluorouracil/Mitomycin/Streptozocin|5-FU/MITO/SZC|SMF
C9669	Cyclophosphamide_Cytarabine_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Methotrexate/Vincristine|ARA-C/CTX/MTX/VCR|COMLA
C9670	Dactinomycin_Ifosfamide_Vincristine	Chemotherapy_Regimen	Dactinomycin/Ifosfamide/Vincristine|DACT/IFF/VCR
C9671	Bleomycin_Carboplatin_Etoposide	Chemotherapy_Regimen	Bleomycin/Carboplatin/Etoposide|BLEO/CBDCA/VP-16
C9672	Epirubicin_Fluorouracil_Mitomycin	Chemotherapy_Regimen	Epirubicin/Fluorouracil/Mitomycin|EPI/5-FU/MITO
C9673	Bleomycin_Cyclophosphamide_Dexamethasone_Methotrexate_Mitoxantrone_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Dexamethasone/Methotrexate/Mitoxantrone/Vincristine|BLEO/CTX/DHAD/DM/MTX/VCR|M-BNCOD
C9674	Bleomycin_Cyclophosphamide_Dexamethasone_Doxorubicin_Methotrexate_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Dexamethasone/Doxorubicin/Methotrexate/Vincristine|BLEO/CTX/DM/DOX/MTX/VCR|M-BACOD
C9675	Amsacrine_Azacytidine_Etoposide	Chemotherapy_Regimen	Amsacrine/Azacytidine/Etoposide|AMSA/AZA/VP-16|AVA|MAZE
C9676	Chlorambucil_Dactinomycin_Methotrexate	Chemotherapy_Regimen	Chlorambucil/Dactinomycin/Methotrexate|CLB/DACT/MTX|MDC
C9677	Cyclophosphamide_Cytarabine_Thioguanine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Thioguanine|ARA-C/CTX/TG
C9678	Fluorouracil_Methotrexate_Mitoxantrone	Chemotherapy_Regimen	Fluorouracil/Methotrexate/Mitoxantrone|DHAD/5-FU/MTX|MMF|NMF
C9679	Cyclophosphamide_Doxorubicin_Etoposide_Mechlorethamine_Methotrexate_Prednisone_Procarbazine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Mechlorethamine/Methotrexate/Prednisone/Procarbazine/Vincristine|CTX/DOX/MTX/NM/PCB/PRED/VCR/VP-16|ProMACE-MOPP|ProMACE/MOPP
C9680	Cisplatin_Etoposide_Methotrexate	Chemotherapy_Regimen	Cisplatin/Etoposide/Methotrexate|CDDP/MTX/VP-16|MEP
C9681	Asparaginase_Doxorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Doxorubicin/Prednisone/Vincristine|ASP/DOX/PRED/VCR|VAAP
C9682	Cyclophosphamide_Doxorubicin_Fluorouracil_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Vincristine|COAd/CO-5|CTX/DOX/5-FU/VCR|FACV
C9683	Carmustine_Cyclophosphamide_Cytarabine_Etoposide	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Cytarabine/Etoposide|ARA-C/BCNU/CTX/VP-16|BEAC
C9684	Cyclophosphamide_Doxorubicin_Etoposide	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide|ACE-II|AVE|CAE|CAVP|CAVP-16|CDE|CED|CTX/DOX/VP-16
C9685	Carboplatin_Cyclophosphamide_Thiotepa	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Thiotepa|CBDCA/CTX/TSPA|CBDCA/Cyclophosphamide/Thiotepa|CTCb|Cyclophosphamide/Thiotepa/Carboplatin|STAMP V
C9686	Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Etoposide/Vincristine|CDDP/CTX/DOX/VCR/VP-16
C9687	Carmustine_Cisplatin_Dacarbazine_Tamoxifen	Chemotherapy_Regimen	Carmustine/Cisplatin/Dacarbazine/Tamoxifen|BCNU/CDDP/DTIC/TMX|Dartmouth Regimen
C9688	Cisplatin_Etoposide_Fluorouracil	Chemotherapy_Regimen	Cisplatin/Etoposide/Fluorouracil|CDDP/5-FU/VP-16
C9689	Cisplatin_Etoposide_Vindesine	Chemotherapy_Regimen	Cisplatin/Etoposide/Vindesine|CDDP/DAVA/VP-16|PEV|VEP
C9690	Cyclophosphamide_Fluorouracil_Mitoxantrone	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Mitoxantrone|CNF|CTX/DHAD/5-FU
C9691	Asparaginase_Cyclophosphamide_Doxorubicin_Prednisolone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Doxorubicin/Prednisolone/Vincristine|ASP/CTX/DOX/PRDL/VCR
C9692	Cisplatin_Cyclophosphamide_Dacarbazine_Doxorubicin_Mechlorethamine_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Dacarbazine/Doxorubicin/Mechlorethamine/Vincristine|CDDP/CTX/DOX/DTIC/NM/VCR|MADDOC
C9693	Cisplatin_Etoposide_Vinblastine	Chemotherapy_Regimen	Cisplatin/Etoposide/Vinblastine|CDDP/VBL/VP-16|VPV
C9694	Bleomycin_Cisplatin_Methotrexate_Vinblastine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Methotrexate/Vinblastine|BLEO/CDDP/MTX/VBL
C9695	Doxorubicin_Fluoxymesterone_mitolactol_Tamoxifen_Vincristine	Chemotherapy_Regimen	Doxorubicin/Fluoxymesterone/Mitolactol/Tamoxifen/Vincristine|DAVTH|DBD/DOX/FXM/TMX/VCR
C9696	Carmustine_Cyclophosphamide_Doxorubicin_Melphalan	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Doxorubicin/Melphalan|BCNU/CTX/DOX/L-PAM
C9697	Cyclophosphamide_Dacarbazine_Doxorubicin	Chemotherapy_Regimen	Cyclophosphamide/Dacarbazine/Doxorubicin|CAD|CIA|CTX/DOX/DTIC
C9698	Bleomycin_Cyclophosphamide_Dexamethasone_Doxorubicin_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Dexamethasone/Doxorubicin/Vincristine|BACOD|BLEO/CTX/DM/DOX/VCR
C9699	Doxorubicin_Fluorouracil_Mitomycin_Streptozocin	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Mitomycin/Streptozocin|DOX/5-FU/MITO/SZC|FAM-S
C9700	Cyclophosphamide_Etoposide_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Methotrexate/Vincristine|CTX/MTX/VCR/VP-16|ECMV
C9701	Melphalan_Procarbazine_Vinblastine	Chemotherapy_Regimen	Melphalan/Procarbazine/Vinblastine|L-PAM/PCB/VBL|PAVe
C9702	Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Prednisone/Vincristine|CHOPE|EPOCH|VAC0P
C9703	Fluorouracil_Methotrexate_Thiotepa	Chemotherapy_Regimen	Fluorouracil/Methotrexate/Thiotepa|5-FU/MTX/TSPA
C9704	Cisplatin_Cyclophosphamide_Vindesine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Vindesine|CDDP/CTX/DAVA|PCE
C9705	Cisplatin_Doxorubicin_Ifosfamide_Methotrexate	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Ifosfamide/Methotrexate|CDDP/DOX/IFF/MTX
C9706	Fluorouracil_Leucovorin-Calcium_Mitoxantrone	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Mitoxantrone|CF/DHAD/5-FU
C9707	Cyclophosphamide_Etoposide_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Vincristine|CTX/VCR/VP-16
C9708	Mitoxantrone_Prednisone_Procarbazine_Vincristine	Chemotherapy_Regimen	Mitoxantrone/Prednisone/Procarbazine/Vincristine|DHAD/PCB/PRED/VCR
C9709	Bleomycin_Cyclophosphamide_Doxorubicin_Prednisone_Teniposide_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Doxorubicin/Prednisone/Teniposide/Vincristine|BLEO/CTX/DOX/PRED/VCR/VM-26|CHVMP/VCR-BLEO
C9710	Doxorubicin_Etoposide_Vinblastine	Chemotherapy_Regimen	Doxorubicin/Etoposide/Vinblastine|DOX/VBL/VP-16|EVA
C9711	Cyclophosphamide_Etoposide_Lomustine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Lomustine/Vincristine|CCNU/CTX/VCR/VP-16|CCVV
C9712	Bleomycin_Cyclophosphamide_Semustine_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Semustine/Vincristine|BLEO/CTX/MeCCNU/VCR|COMB
C9713	Cyclophosphamide_Etoposide	Chemotherapy_Regimen	Cyclophosphamide/Etoposide|CTX/VP-16|CV
C9714	Cisplatin_Cyclophosphamide_Etoposide_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Etoposide/Vincristine|CDDP/CTX/VCR/VP-16|COPE|EPOC
C9715	Cisplatin_Cyclophosphamide_Mitoxantrone	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Mitoxantrone|CDDP/CTX/DHAD
C9716	Melphalan_Prednisone	Chemotherapy_Regimen	Melphalan/Prednisone|L-PAM/PRED|MP
C9717	Cisplatin_Methotrexate_Vinblastine	Chemotherapy_Regimen	Cisplatin/Methotrexate/Vinblastine|CDDP/MTX/VBL|CMV|MEC Protocol 1
C9718	Cisplatin_Dacarbazine_Vinblastine	Chemotherapy_Regimen	Cisplatin/Dacarbazine/Vinblastine|CDDP/DTIC/VBL|VDP
C9719	Cisplatin_Doxorubicin_Vincristine	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Vincristine|APO|CDDP/DOX/VCR
C9720	Cisplatin_Cytarabine_Etoposide_Methylprednisolone	Chemotherapy_Regimen	Cisplatin/Cytarabine/Etoposide/Methylprednisolone|ARA-C/CDDP/MePRDL/VP-16|E-SHAP|ESHAP
C9721	Cyclophosphamide_Doxorubicin_Etoposide_Methotrexate_Prednisolone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Methotrexate/Prednisolone/Vincristine|CTX/DOX/MTX/PRDL/VCR/VP-16
C9722	Amsacrine_Cytarabine_Etoposide	Chemotherapy_Regimen	Amsacrine/Cytarabine/Etoposide|AMSA/ARA-C/VP-16
C9723	Cytarabine_Etoposide_Mitoxantrone	Chemotherapy_Regimen	Cytarabine/Etoposide/Mitoxantrone|ARA-C/DHAD/VP-16|MCE
C9724	Doxorubicin_Etoposide_Procarbazine_Vincristine	Chemotherapy_Regimen	Doxorubicin/Etoposide/Procarbazine/Vincristine|APVV|DOX/PCB/VCR/VP-16
C9725	Altretamine_Mitomycin_Vinblastine	Chemotherapy_Regimen	Altretamine/Mitomycin/Vinblastine|HMM/MITO/VBL|HMVlb
C9726	Doxorubicin_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Leucovorin Calcium|CF/DOX/5-FU
C9727	Cisplatin_Ifosfamide_Vincristine	Chemotherapy_Regimen	Cisplatin/Ifosfamide/Vincristine|CDDP/IFF/VCR|HOP
C9728	Carboplatin_Doxorubicin_Etoposide	Chemotherapy_Regimen	Carboplatin/Doxorubicin/Etoposide|CBDCA/DOX/VP-16
C9729	Cyclophosphamide_Bleomycin_Epirubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Bleomycin/Epirubicin/Prednisone/Vincristine|BLEO/CTX/EPI/PRED/VCR
C9730	Cisplatin_Cytarabine_Doxorubicin_Methylprednisolone	Chemotherapy_Regimen	Cisplatin/Cytarabine/Doxorubicin/Methylprednisolone|A-SHAP|ARA-C/CDDP/DOX/MePRDL|ASHAP
C9731	Bleomycin_Doxorubicin_Etoposide_Mechlorethamine_Prednisone_Vinblastine_Vincristine	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Etoposide/Mechlorethamine/Prednisone/Vinblastine/Vincristine|BLEO/DOX/NM/PRED/VBL/VCR/VP-16
C9732	Carmustine_Cyclophosphamide_Etoposide_Hydroxyurea	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Etoposide/Hydroxyurea|BCNU/CTX/HU/VP-16
C9733	Cisplatin_Doxorubicin_Methotrexate	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Methotrexate|AMDDP|CDDP/DOX/MTX
C9734	Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Etoposide|CDDP/CTX/DOX/VP-16|CECA|PACE
C9735	Ifosfamide_Cyclophosphamide_Etoposide	Chemotherapy_Regimen	Ifosfamide/Cyclophosphamide/Etoposide|CTX/IFF/VP-16
C9736	Estradiol_Norethindrone	Chemotherapy_Regimen	Estradiol/Norethindrone|ESDL/NORETHIN
C9737	Asparaginase_Cyclophosphamide_Daunorubicin_Dexamethasone_Methotrexate_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Daunorubicin/Dexamethasone/Methotrexate/Vincristine|ASP/CTX/DM/DNR/MTX/VCR
C9738	Doxorubicin_Vincristine_VX-710	Chemotherapy_Regimen	Doxorubicin/Vincristine/VX-710|DOX/VCR/VX-710
C9739	Carboplatin_Cyclophosphamide_Vincristine	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Vincristine|CBDCA/CTX/VCR
C9740	Docetaxol_Vinblastine	Chemotherapy_Regimen	Docetaxol/Vinblastine
C9741	Docetaxol_Etoposide	Chemotherapy_Regimen	Docetaxol/Etoposide
C9742	Docetaxol_cyclophosphamide	Retired_Concepts	Docetaxol/cyclophosphamide
C9743	Cyclophosphamide_Doxorubicin_Uracil_Tegafur_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Uracil/Tegafur/Tamoxifen
C9744	Doxifluridine_L-Leucovorin	Chemotherapy_Regimen	Doxifluridine/L-Leucovorin
C9745	Carboplatin_Etoposide_Cyclophosphamide_Thiotepa	Chemotherapy_Regimen	Carboplatin/Etoposide/Cyclophosphamide/Thiotepa|CECaT
C9746	Docetaxel_Vincristine	Chemotherapy_Regimen	Docetaxel/Vincristine
C9747	Docetaxel_Vinblastine	Chemotherapy_Regimen	Docetaxel/Vinblastine
C9748	Cyclophosphamide_Doxorubicin_Fluorouracil_Tegafur_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Tegafur/Tamoxifen
C9749	Paclitaxel_Cisplatin_Topotecan_G-CSF	Chemotherapy_Regimen	Paclitaxel/Cisplatin/Topotecan/G-CSF
C9750	Lovastatin_Sulindac	Chemotherapy_Regimen	Lovastatin/Sulindac
C9751	Maxamine_Interleukin-2	Chemotherapy_Regimen	Maxamine/Interleukin-2
C9752	Maxamine_Interferon-Alpha	Chemotherapy_Regimen	Maxamine/Interferon Alpha
C9753	Fluorouracil_Mitomycin-C_Cisplatin	Chemotherapy_Regimen	Fluorouracil/Mitomycin C/Cisplatin
C9754	Etoposide_Fluorouracil_Folinic-Acid	Chemotherapy_Regimen	Etoposide/Fluorouracil/Folinic Acid
C9755	Epirubicin_Folinic-Acid_Fluorouracil_Etoposide	Chemotherapy_Regimen	Epirubicin/Folinic Acid/Fluorouracil/Etoposide
C9756	Paclitaxel_Beta-Lapachone	Chemotherapy_Regimen	Paclitaxel/Beta-Lapachone
C9757	Thymalfasin_Dacarbazine	Chemotherapy_Regimen	Thymalfasin/Dacarbazine
C9758	Vitamin-E_Fluorouracil	Chemotherapy_Regimen	Vitamin E/Fluorouracil
C9759	Herceptin_Paclitaxel	Chemotherapy_Regimen	Herceptin/Paclitaxel
C9760	Rituximab_Cyclophosphamide_Doxorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Rituximab/Cyclophosphamide/Doxorubicin/Prednisone/Vincristine
C9761	Fluorouracil_Leucovorin_Rhumab-Vegf	Chemotherapy_Regimen	Fluorouracil/Leucovorin/Rhumab-Vegf
C9762	L-744-832_Paclitaxel	Chemotherapy_Regimen	L-744,832/Paclitaxel
C9763	p53-Adenovirus_SCH-66336	Chemotherapy_Regimen	p53 Adenovirus/SCH 66336|p53 Adenovirus/Lonafarnib
C9764	_16-88_88BV59	Chemotherapy_Regimen	16.88/88BV59|HumaRAD
C9765	Cytarabine_Etoposide_Idarubicin	Chemotherapy_Regimen	Cytarabine/Etoposide/Idarubicin|ARA-C/IDA/VP-16
C9766	Cyclophosphamide_Thiotepa	Chemotherapy_Regimen	Cyclophosphamide/Thiotepa|CHUT|CTX/TSPA
C9767	Cyclophosphamide_Doxorubicin_Fluorouracil_Fluoxymesterone_Interferon-alfa_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Fluoxymesterone/Interferon Alfa/Tamoxifen|CTX/DOX/5-FU/FXM/IFN-A/TMX
C9768	Cisplatin_Mitomycin	Chemotherapy_Regimen	Cisplatin/Mitomycin|CDDP/MITO
C9769	Amsacrine_Cytarabine	Chemotherapy_Regimen	Amsacrine/Cytarabine|AMSA/ARA-C
C9770	Azacytidine_Etoposide	Chemotherapy_Regimen	Azacytidine/Etoposide|AZA/VP-16
C9771	Cyclophosphamide_Doxorubicin_Etoposide_Methotrexate_Prednisone	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Methotrexate/Prednisone|CTX/DOX/MTX/PRED/VP-16|ProMACE|ProMACE/Cyclophosphamide
C9772	Bleomycin_Lomustine_Methotrexate	Chemotherapy_Regimen	Bleomycin/Lomustine/Methotrexate|BLEO/CCNU/MTX
C9773	Bleomycin_Lomustine_Methotrexate_Vinblastine	Chemotherapy_Regimen	Bleomycin/Lomustine/Methotrexate/Vinblastine|BLEO/CCNU/MTX/VBL
C9774	Busulfan_Cyclophosphamide	Chemotherapy_Regimen	Busulfan/Cyclophosphamide|BU/CTX
C9775	Amsacrine_Cyclophosphamide_Etoposide	Chemotherapy_Regimen	Amsacrine/Cyclophosphamide/Etoposide|AMSA/CTX/VP-16
C9776	Cisplatin_Cytarabine	Chemotherapy_Regimen	Cisplatin/Cytarabine|ARA-C/CDDP
C9777	Cyclophosphamide_Doxorubicin_Prednisone	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Prednisone|CTX/DOX/PRED
C9778	Etoposide_Vincristine	Chemotherapy_Regimen	Etoposide/Vincristine|VCR/VP-16
C9779	Interferon-Gamma_Interleukin-2	Chemotherapy_Regimen	Interferon Gamma/Interleukin-2|IFN-G/IL-2
C9780	Asparaginase_Mercaptopurine_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Mercaptopurine/Prednisone/Vincristine|ASP/MP/PRED/VCR
C9781	Cytarabine_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Cytarabine/Mercaptopurine/Methotrexate/Prednisone/Vincristine|ARA-C/MP/MTX/PRED/VCR
C9782	Bleomycin_Carboplatin	Chemotherapy_Regimen	Bleomycin/Carboplatin|BLEO/CBDCA
C9783	Carmustine_Cisplatin_Cyclophosphamide	Chemotherapy_Regimen	Carmustine/Cisplatin/Cyclophosphamide|BCNU/CDDP/CTX|STAMP I
C9784	Fluorouracil_Idoxuridine	Chemotherapy_Regimen	Fluorouracil/Idoxuridine|5-FU/IUDR
C9785	Asparaginase_Etoposide_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Etoposide/Prednisone/Vincristine|ASP/PRED/VCR/VP-16
C9786	Fluorouracil_Methylmercaptopurine-Riboside_PALA	Chemotherapy_Regimen	Fluorouracil/Methylmercaptopurine Riboside/PALA|5-FU/MMPR/PALA
C9787	Doxorubicin_Interleukin-2	Chemotherapy_Regimen	Doxorubicin/Interleukin-2|DOX/IL-2
C9788	Mechlorethamine_Prednisone_Procarbazine_Vinblastine	Chemotherapy_Regimen	Mechlorethamine/Prednisone/Procarbazine/Vinblastine|MVPP|NM/PCB/PRED/VBL
C9789	Cyclophosphamide_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Mercaptopurine/Methotrexate/Prednisone/Vincristine|COMMP|CTX/MP/MTX/PRED/VCR
C9790	Busulfan_Cyclophosphamide_Etoposide	Chemotherapy_Regimen	Busulfan/Cyclophosphamide/Etoposide|BU/CTX/VP-16
C9791	Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium|5FU/Leucovorin|CF/5-FU
C9792	Carboplatin_Cisplatin	Chemotherapy_Regimen	Carboplatin/Cisplatin|CBDCA/CDDP
C9793	Carmustine_Cisplatin_Etoposide	Chemotherapy_Regimen	Carmustine/Cisplatin/Etoposide|BCNU/CDDP/VP-16
C9794	Cisplatin_Mitolactol	Chemotherapy_Regimen	Cisplatin/Mitolactol|CDDP/DBD
C9795	Asparaginase_Cytarabine	Chemotherapy_Regimen	Asparaginase/Cytarabine|ARA-C/ASP
C9796	Cytarabine_Methotrexate_Methylprednisolone	Chemotherapy_Regimen	Cytarabine/Methotrexate/Methylprednisolone|ARA-C/MePRDL/MTX
C9797	Asparaginase_Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Methotrexate_Thioguanine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Methotrexate/Thioguanine/Vincristine|ARA-C/ASP/CTX/DM/DOX/MTX/TG/VCR
C9798	Cyclophosphamide_Etoposide_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Methotrexate|CMV|CTX/MTX/VP-16
C9799	Cyproterone_Goserelin	Chemotherapy_Regimen	Cyproterone/Goserelin|CPTR/ZDX
C9800	Cyclophosphamide_Cytarabine_Doxorubicin_Hydroxyurea_Lomustine_Methotrexate_Thioguanine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Doxorubicin/Hydroxyurea/Lomustine/Methotrexate/Thioguanine/Vincristine|ARA-C/CCNU/CTX/DOX/HU/MTX/TG/VCR
C9801	Cisplatin_Dacarbazine	Chemotherapy_Regimen	Cisplatin/Dacarbazine|CDDP/DTIC
C9802	Interferon-Beta_Interleukin-2	Chemotherapy_Regimen	Interferon Beta/Interleukin-2|IFN-B/IL-2
C9803	Interferon-Beta_Interferon-Gamma	Chemotherapy_Regimen	Interferon Beta/Interferon Gamma|IFN-B/IFN-G
C9804	Goserelin_Nilutamide	Chemotherapy_Regimen	Goserelin/Nilutamide|ANAN/ZDX
C9805	Flutamide_Goserelin	Chemotherapy_Regimen	Flutamide/Goserelin|FLUT/ZDX
C9806	Dacarbazine_Etoposide_Hydroxyurea	Chemotherapy_Regimen	Dacarbazine/Etoposide/Hydroxyurea|DTIC/HU/VP-16|HED
C9807	Carboplatin_Fluorouracil	Chemotherapy_Regimen	Carboplatin/Fluorouracil|CBDCA/5-FU
C9808	Carboplatin_Etoposide_Thiotepa	Chemotherapy_Regimen	Carboplatin/Etoposide/Thiotepa|CBDCA/TSPA/VP-16
C9809	Asparaginase_Cyclophosphamide_Cytarabine_Methotrexate_Prednisone_Thioguanine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Methotrexate/Prednisone/Thioguanine/Vincristine|ARA-C/ASP/CTX/MTX/PRED/TG/VCR
C9810	Carmustine_Cyclophosphamide_Dactinomycin_Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Dactinomycin/Doxorubicin/Mercaptopurine/Methotrexate/Prednisone/Vincristine|BCNU/CTX/DACT/DOX/MP/MTX/PRED/VCR
C9811	Cisplatin_Thiotepa	Chemotherapy_Regimen	Cisplatin/Thiotepa|CDDP/TSPA
C9812	Carboplatin_Cisplatin_Cyclophosphamide	Chemotherapy_Regimen	Carboplatin/Cisplatin/Cyclophosphamide|CBDCA/CDDP/CTX|CPC
C9813	Fluorouracil_Leucovorin-Calcium_Levamisole	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Levamisole|5FU/Leucovorin/Levamisole|CF/5-FU/LEV
C9814	Asparaginase_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Mercaptopurine/Methotrexate/Prednisone/Vincristine|ASP/MP/MTX/PRED/VCR
C9815	Asparaginase_Doxorubicin_Mercaptopurine_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Doxorubicin/Mercaptopurine/Prednisone/Vincristine|ASP/DOX/MP/PRED/VCR
C9816	Fluorouracil_Methotrexate_Mitomycin	Chemotherapy_Regimen	Fluorouracil/Methotrexate/Mitomycin|5-FU/MITO/MTX
C9817	Mercaptopurine_Methotrexate_Prednisone_Vindesine	Chemotherapy_Regimen	Mercaptopurine/Methotrexate/Prednisone/Vindesine|DAVA/MP/MTX/PRED
C9818	Doxorubicin_Ifosfamide	Chemotherapy_Regimen	Doxorubicin/Ifosfamide|DOX/IFF
C9819	Cyclophosphamide_Doxorubicin_Interferon-alfa_Interleukin-2_Lymphokine-Activated-Killer-Cells	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Interferon alfa/Interleukin-2/Lymphokine-Activated Killer Cells|CTX/DOX/IFN-A/IL-2/LAK
C9820	Cisplatin_Teniposide	Chemotherapy_Regimen	Cisplatin/Teniposide|CDDP/VM-26
C9821	Cisplatin_Cytarabine_Etoposide_Vinblastine	Chemotherapy_Regimen	Cisplatin/Cytarabine/Etoposide/Vinblastine|ARA-C/CDDP/VBL/VP-16|EVAP
C9822	Ifosfamide_Lomustine_Vinblastine	Chemotherapy_Regimen	Ifosfamide/Lomustine/Vinblastine|CCNU/IFF/VBL|VIC
C9823	Bleomycin_Lomustine	Chemotherapy_Regimen	Bleomycin/Lomustine|BLEO/CCNU
C9824	Doxorubicin_Floxuridine	Chemotherapy_Regimen	Doxorubicin/Floxuridine|DOX/FUDR
C9825	Asparaginase_Daunorubicin_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Daunorubicin/Methotrexate/Prednisone/Vincristine|ASP/DNR/MTX/PRED/VCR
C9826	Cyclophosphamide_Cytarabine_Mercaptopurine_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Mercaptopurine/Methotrexate|ARA-C/CTX/MP/MTX
C9827	Asparaginase_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Methotrexate/Prednisone/Vincristine|ASP/MTX/PRED/VCR
C9828	Dexamethasone_Methotrexate_Thioguanine	Chemotherapy_Regimen	Dexamethasone/Methotrexate/Thioguanine|DM/MTX/TG
C9829	Asparaginase_Cyclophosphamide_Cytarabine_Doxorubicin_Methotrexate_Thioguanine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Doxorubicin/Methotrexate/Thioguanine/Vincristine|ARA-C/ASP/CTX/DOX/MTX/TG/VCR
C9830	Fluorouracil_Streptozocin	Chemotherapy_Regimen	Fluorouracil/Streptozocin|5-FU/SZC
C9831	Doxorubicin_Mitolactol	Chemotherapy_Regimen	Doxorubicin/Mitolactol|DBD/DOX
C9832	Amsacrine_Etoposide	Chemotherapy_Regimen	Amsacrine/Etoposide|AMSA/VP-16
C9833	Cyclophosphamide_Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Mercaptopurine/Methotrexate/Prednisone/Vincristine|CTX/DOX/MP/MTX/PRED/VCR
C9834	Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Doxorubicin/Mercaptopurine/Methotrexate/Prednisone/Vincristine|DOX/MP/MTX/PRED/VCR
C9835	Buserelin_Tamoxifen	Chemotherapy_Regimen	Buserelin/Tamoxifen|BSRL/TMX
C9836	Asparaginase_Cyclophosphamide_Doxorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Doxorubicin/Prednisone/Vincristine|ASP/CTX/DOX/PRED/VCR
C9837	Cytarabine_Idarubicin	Chemotherapy_Regimen	Cytarabine/Idarubicin|ARA-C/IDA
C9838	Mercaptopurine_Methotrexate_Pentostatin	Chemotherapy_Regimen	Mercaptopurine/Methotrexate/Pentostatin|DCF/MP/MTX
C9839	Cyclophosphamide_Fluorouracil_Menogaril	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Menogaril|CTX/5-FU/MEN
C9840	Aminoglutethimide_Megestrol	Chemotherapy_Regimen	Aminoglutethimide/Megestrol|AGT/MEG
C9841	Cisplatin_Trimetrexate-Glucuronate	Chemotherapy_Regimen	Cisplatin/Trimetrexate Glucuronate|CDDP/TMTX
C9842	Etoposide_Trimetrexate-Glucuronate	Chemotherapy_Regimen	Etoposide/Trimetrexate Glucuronate|TMTX/VP-16
C9843	Carmustine_Cisplatin	Chemotherapy_Regimen	Carmustine/Cisplatin|BCNU/CDDP
C9844	Prednisone_Vincristine	Chemotherapy_Regimen	Prednisone/Vincristine|PRED/VCR
C9845	Asparaginase_Cytarabine_Daunorubicin_Methotrexate_Prednisone_Teniposide_Vincristine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Daunorubicin/Methotrexate/Prednisone/Teniposide/Vincristine|ARA-C/ASP/DNR/MTX/PRED/VCR/VM-26
C9846	Etoposide_Ifosfamide_Vincristine	Chemotherapy_Regimen	Etoposide/Ifosfamide/Vincristine|IFF/VCR/VP-16
C9847	Cytarabine_Sargramostim	Chemotherapy_Regimen	Cytarabine/Sargramostim|ARA-C/GM-CSF
C9848	Amsacrine_Cytarabine_Daunorubicin	Chemotherapy_Regimen	Amsacrine/Cytarabine/Daunorubicin|AMSA/ARA-C/DNR
C9849	Cyclophosphamide_Cytarabine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Vincristine|ARA-C/CTX/VCR|cytarabine/cyclophosphamide/vincristine
C9850	Buserelin_Cyproterone	Chemotherapy_Regimen	Buserelin/Cyproterone|BSRL/CPTR
C9851	Dexamethasone_Methotrexate_Zidovudine	Chemotherapy_Regimen	Dexamethasone/Methotrexate/Zidovudine|DM/MTX/ZDV
C9852	Doxorubicin_Ifosfamide_Sargramostim	Chemotherapy_Regimen	Doxorubicin/Ifosfamide/Sargramostim|DOX/GM-CSF/IFF
C9853	Cisplatin_Etoposide_Interleukin-2_Lymphokine-Activated-Killer-Cells	Chemotherapy_Regimen	Cisplatin/Etoposide/Interleukin-2/Lymphokine-Activated Killer Cells|CDDP/IL-2/LAK/VP-16
C9854	Doxorubicin_Prednisone	Chemotherapy_Regimen	Doxorubicin/Prednisone|DOX/PRED
C9855	Doxorubicin_Etoposide_Quinidine	Chemotherapy_Regimen	Doxorubicin/Etoposide/Quinidine|DOX/QND/VP-16
C9856	Fluorouracil_Methotrexate_Tamoxifen	Chemotherapy_Regimen	Fluorouracil/Methotrexate/Tamoxifen|5-FU/MTX/TMX
C9857	Etoposide_Methotrexate_Mitomycin	Chemotherapy_Regimen	Etoposide/Methotrexate/Mitomycin|MITO/MTX/VP-16
C9858	Cyclophosphamide_Etanidazole	Chemotherapy_Regimen	Cyclophosphamide/Etanidazole|CTX/SR-2508
C9859	Fludarabine_Pentostatin	Chemotherapy_Regimen	Fludarabine/Pentostatin|DCF/FAMP
C9860	Diaziquone_Mitoxantrone	Chemotherapy_Regimen	Diaziquone/Mitoxantrone|AZQ/DHAD
C9861	Pegaspargase_Prednisone_Vincristine	Chemotherapy_Regimen	Pegaspargase/Prednisone/Vincristine|PEG-ASP/PRED/VCR
C9862	Diaziquone_Etoposide	Chemotherapy_Regimen	Diaziquone/Etoposide|AZQ/VP-16
C9863	Etoposide_Mitoxantrone	Chemotherapy_Regimen	Etoposide/Mitoxantrone|DHAD/VP-16
C9864	Cisplatin_Cyclophosphamide_Melphalan	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Melphalan|CDDP/CTX/L-PAM
C9865	Cyclophosphamide_Doxorubicin_Methylprednisolone_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Methylprednisolone/Prednisone/Vincristine|CTX/DOX/MePRDL/PRED/VCR
C9866	Asparaginase_Cytarabine_Doxorubicin_Teniposide	Chemotherapy_Regimen	Asparaginase/Cytarabine/Doxorubicin/Teniposide|ARA-C/ASP/DOX/VM-26
C9867	Cyclophosphamide_Cytarabine_Teniposide	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Teniposide|ARA-C/CTX/VM-26
C9868	Asparaginase_Dexamethasone_Doxorubicin_Vincristine	Chemotherapy_Regimen	Asparaginase/Dexamethasone/Doxorubicin/Vincristine|ASP/DM/DOX/VCR
C9869	Asparaginase_Cyclophosphamide_Daunorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Daunorubicin/Prednisone/Vincristine|ASP/CTX/DNR/PRED/VCR
C9870	Asparaginase_Cytarabine_Carmustine_Thioguanine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Carmustine/Thioguanine|ARA-C/ASP/BCNU/TG
C9871	Carmustine_Cyclophosphamide_Cytarabine_Daunorubicin_Hydroxyurea_Methotrexate_Thioguanine_Vincristine	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Cytarabine/Daunorubicin/Hydroxyurea/Methotrexate/Thioguanine/Vincristine|ARA-C/BCNU/CTX/DNR/HU/MTX/TG/VCR
C9872	Asparaginase_Cytarabine_Methotrexate_Prednisone_Thioguanine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Methotrexate/Prednisone/Thioguanine/Vincristine|ARA-C/ASP/MTX/PRED/TG/VCR
C9873	Cyclophosphamide_Cytarabine_Mercaptopurine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Mercaptopurine|ARA-C/CTX/MP
C9874	Cyclophosphamide_Fluorouracil_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Methotrexate|CMF|CTX/5-FU/MTX
C9875	Cisplatin_Cytarabine_Etoposide	Chemotherapy_Regimen	Cisplatin/Cytarabine/Etoposide|ACE|APE|ARA-C/CDDP/VP-16
C9876	Cytarabine_Mercaptopurine_Methotrexate	Chemotherapy_Regimen	Cytarabine/Mercaptopurine/Methotrexate|ARA-C/MP/MTX
C9877	Indomethacin_Interleukin-1-Alpha	Chemotherapy_Regimen	Indomethacin/Interleukin-1-Alpha|IL-1A/indomethacin
C9878	Carboplatin_Cyclophosphamide_Etoposide	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Etoposide|CBDCA/CTX/VP-16
C9879	Cyclophosphamide_Interleukin-2_Tumor-Necrosis-Factor	Chemotherapy_Regimen	Cyclophosphamide/Interleukin-2/Tumor Necrosis Factor|CTX/IL-2/TNF
C9880	Mitoxantrone_Sargramostim	Chemotherapy_Regimen	Mitoxantrone/Sargramostim|DHAD/GM-CSF
C9881	Dexrazoxane_Doxorubicin_Sargramostim	Chemotherapy_Regimen	Dexrazoxane/Doxorubicin/Sargramostim|ADR-529/DOX/GM-CSF
C9882	Cyclophosphamide_Diaziquone	Chemotherapy_Regimen	Cyclophosphamide/Diaziquone|AZQ/CTX
C9883	Cytarabine_Daunorubicin_Etoposide_Sargramostim	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Etoposide/Sargramostim|ARA-C/DNR/GM-CSF/VP-16
C9884	Chlorambucil_Pentostatin_Prednisone	Chemotherapy_Regimen	Chlorambucil/Pentostatin/Prednisone|CLB/DCF/PRED
C9885	Cisplatin_Mitotane	Chemotherapy_Regimen	Cisplatin/Mitotane|CDDP/DDD
C9886	Bleomycin_Cyclophosphamide_Doxorubicin_Methotrexate_Methylprednisolone_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Doxorubicin/Methotrexate/Methylprednisolone/Vincristine|BLEO/CTX/DOX/MePRDL/MTX/VCR
C9887	Etoposide_Mitoxantrone_Prednimustine	Chemotherapy_Regimen	Etoposide/Mitoxantrone/Prednimustine|DHAD/PM/VP-16
C9888	Cisplatin_Melphalan	Chemotherapy_Regimen	Cisplatin/Melphalan|CDDP/L-PAM|Melphalan/Cisplatin
C9889	Cytarabine_Doxorubicin_Thioguanine	Chemotherapy_Regimen	Cytarabine/Doxorubicin/Thioguanine|ARA-C/DOX/TG
C9890	Etoposide_Ifosfamide_Sargramostim	Chemotherapy_Regimen	Etoposide/Ifosfamide/Sargramostim|GM-CSF/IFF/VP-16
C9891	Etoposide_Filgrastim_Ifosfamide	Chemotherapy_Regimen	Etoposide/Filgrastim/Ifosfamide|G-CSF/IFF/VP-16
C9892	Etoposide_Ifosfamide_Interleukin-3	Chemotherapy_Regimen	Etoposide/Ifosfamide/Interleukin-3|IFF/IL-3/VP-16
C9893	Cyclophosphamide_Doxorubicin_Methotrexate_Sargramostim_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Methotrexate/Sargramostim/Vincristine|CTX/DOX/GM-CSF/MTX/VCR
C9894	Cytarabine_Etoposide_Ifosfamide	Chemotherapy_Regimen	Cytarabine/Etoposide/Ifosfamide|ARA-C/IFF/VP-16
C9895	Cytarabine_Etoposide_Ifosfamide_Sargramostim	Chemotherapy_Regimen	Cytarabine/Etoposide/Ifosfamide/Sargramostim|ARA-C/GM-CSF/IFF/VP-16
C9896	Bleomycin_Doxorubicin_Vincristine_Zidovudine	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Vincristine/Zidovudine|BLEO/DOX/VCR/ZDV
C9897	Cisplatin_Cyclophosphamide_Diethyldithiocarbamate	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Diethyldithiocarbamate|CDDP/CTX/DTC
C9898	Cisplatin_Fluorouracil_Vincristine	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Vincristine|CDDP/5-FU/VCR
C9899	Carmustine_Cisplatin_Dacarbazine_Interleukin-2_Tamoxifen	Chemotherapy_Regimen	Carmustine/Cisplatin/Dacarbazine/Interleukin-2/Tamoxifen|BCNU/CDDP/DTIC/IL-2/TMX
C9900	Cisplatin_Cyclophosphamide_Dacarbazine_Doxorubicin_Etoposide_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Dacarbazine/Doxorubicin/Etoposide/Vincristine|CDDP/CTX/DOX/DTIC/VCR/VP-16
C9901	Medroxyprogesterone_Tamoxifen	Chemotherapy_Regimen	Medroxyprogesterone/Tamoxifen|MPA/TMX
C9902	Cisplatin_Doxorubicin_Octreotide	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Octreotide|CDDP/DOX/SSTN
C9903	Floxuridine_Streptozocin	Chemotherapy_Regimen	Floxuridine/Streptozocin|FUDR/SZC
C9904	Floxuridine_Octreotide_Streptozocin	Chemotherapy_Regimen	Floxuridine/Octreotide/Streptozocin|FUDR/SSTN/SZC
C9905	Asparaginase_Cytarabine_Dexamethasone_Doxorubicin_Thioguanine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Dexamethasone/Doxorubicin/Thioguanine/Vincristine|ARA-C/ASP/DM/DOX/TG/VCR
C9906	Etoposide_Melphalan	Chemotherapy_Regimen	Etoposide/Melphalan|L-PAM/VP-16
C9907	Bleomycin_Cyclophosphamide_Doxorubicin_Mitomycin	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Doxorubicin/Mitomycin|ABCM|BLEO/CTX/DOX/MITO
C9908	Altretamine_Cyclophosphamide_Doxorubicin_Vincristine	Chemotherapy_Regimen	Altretamine/Cyclophosphamide/Doxorubicin/Vincristine|CTX/DOX/HMM/VCR|HEXA-VAC
C9909	Altretamine_Fluorouracil_Mitomycin	Chemotherapy_Regimen	Altretamine/Fluorouracil/Mitomycin|5-FU/HMM/MITO|HEXMF
C9910	Doxorubicin_Ifosfamide_Prednisone_Vincristine	Chemotherapy_Regimen	Doxorubicin/Ifosfamide/Prednisone/Vincristine|DOX/IFF/PRED/VCR|IHOP
C9911	Etoposide_Lomustine_Methotrexate_Prednisone	Chemotherapy_Regimen	Etoposide/Lomustine/Methotrexate/Prednisone|CCNU/MTX/PRED/VP-16|LEMP
C9912	Doxorubicin_Mitomycin	Chemotherapy_Regimen	Doxorubicin/Mitomycin|DOX/MITO|MA
C9913	Altretamine_Carmustine_Mitomycin	Chemotherapy_Regimen	Altretamine/Carmustine/Mitomycin|BCNU/HMM/MITO|MiCH
C9914	Cyclophosphamide_Doxorubicin_Mitomycin	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Mitomycin|CTX/DOX/MITO|MAC
C9915	Asparaginase_Dexamethasone_Methotrexate_Vincristine	Chemotherapy_Regimen	Asparaginase/Dexamethasone/Methotrexate/Vincristine|ASP/DM/MTX/VCR|MOAD
C9916	Cisplatin_Novobiocin	Chemotherapy_Regimen	Cisplatin/Novobiocin|CDDP/NBC
C9917	Cisplatin_Cytarabine_Dexamethasone_Doxorubicin	Chemotherapy_Regimen	Cisplatin/Cytarabine/Dexamethasone/Doxorubicin|ARA-C/CDDP/DM/DOX
C9918	Doxorubicin_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Doxorubicin/Methotrexate/Prednisone/Vincristine|DOX/MTX/PRED/VCR|M-HOP
C9919	Fluorouracil_Hydroxyurea_Leucovorin-Calcium	Chemotherapy_Regimen	Fluorouracil/Hydroxyurea/Leucovorin Calcium|CF/5-FU/HU
C9920	Interleukin-2_Interleukin-4	Chemotherapy_Regimen	Interleukin-2/Interleukin-4|IL-2/IL-4
C9921	Carmustine_Thymidine	Chemotherapy_Regimen	Carmustine/Thymidine|BCNU/TDR
C9922	Asparaginase_Cyclophosphamide_Cytarabine_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Prednisone/Vincristine|ARA-C/ASP/CTX/PRED/VCR
C9923	Asparaginase_Cyclophosphamide_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Prednisone/Vincristine|ASP/CTX/PRED/VCR
C9924	Carboplatin_Sargramostim	Chemotherapy_Regimen	Carboplatin/Sargramostim|CBDCA/GM-CSF
C9925	Cyclophosphamide_Doxorubicin_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Tamoxifen|ACT|CTX/DOX/TMX
C9926	Doxorubicin_Ifosfamide_Methotrexate	Chemotherapy_Regimen	Doxorubicin/Ifosfamide/Methotrexate|DOX/IFF/MTX
C9927	Doxorubicin_Ifosfamide_Vincristine	Chemotherapy_Regimen	Doxorubicin/Ifosfamide/Vincristine|DOX/IFF/VCR
C9928	Dexamethasone_Methotrexate_Procarbazine_Teniposide	Chemotherapy_Regimen	Dexamethasone/Methotrexate/Procarbazine/Teniposide|DM/MTX/PCB/VM-26|MVPD-26
C9929	Cisplatin_Doxorubicin	Chemotherapy_Regimen	Cisplatin/Doxorubicin|AP|CDDP/DOX
C9930	Methotrexate_Piritrexim	Chemotherapy_Regimen	Methotrexate/Piritrexim|MTX/piritrexim
C9931	Asparaginase_Ifosfamide_Methotrexate	Chemotherapy_Regimen	Asparaginase/Ifosfamide/Methotrexate|AIM|ASP/IFF/MTX
C9932	Bleomycin_Cytarabine_Prednisone_Vincristine	Chemotherapy_Regimen	Bleomycin/Cytarabine/Prednisone/Vincristine|ARA-C/BLEO/PRED/VCR|OAP-BLEO
C9933	Chlorambucil_Dacarbazine_Dactinomycin_Doxorubicin_Methotrexate_Vincristine	Chemotherapy_Regimen	Chlorambucil/Dacarbazine/Dactinomycin/Doxorubicin/Methotrexate/Vincristine|ALOMAD|CLB/DACT/DOX/DTIC/MTX/VCR
C9934	Cytarabine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Cytarabine/Methotrexate/Prednisone/Vincristine|AMVP|ARA-C/MTX/PRED/VCR
C9935	Cisplatin_Dianhydrogalactitol_Doxorubicin_Vincristine	Chemotherapy_Regimen	Cisplatin/Dianhydrogalactitol/Doxorubicin/Vincristine|CDDP/DAG/DOX/VCR|ODAP
C9936	Prednisone_Procarbazine_Vincristine	Chemotherapy_Regimen	Prednisone/Procarbazine/Vincristine|OPP|PCB/PRED/VCR
C9937	Cyclophosphamide_Doxorubicin_Prednisone_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Prednisone/Tamoxifen|CTX/DOX/PRED/TMX|PACT
C9938	Bleomycin_Doxorubicin_Lomustine_Vincristine	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Lomustine/Vincristine|BACO|BLEO/CCNU/DOX/VCR
C9939	Fluorouracil_Interleukin-2_Leucovorin-Calcium	Chemotherapy_Regimen	Fluorouracil/Interleukin-2/Leucovorin Calcium|CF/5-FU/IL-2
C9940	Cisplatin_Cyclophosphamide_Etoposide_Sargramostim	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Etoposide/Sargramostim|CDDP/CTX/GM-CSF/VP-16
C9941	Carboplatin_Ifosfamide_Vincristine	Chemotherapy_Regimen	Carboplatin/Ifosfamide/Vincristine|CBDCA/IFF/VCR
C9942	Bleomycin_Doxorubicin_Prednisone	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Prednisone|BAP|BLEO/DOX/PRED
C9943	Fluorouracil_Melphalan_Tamoxifen	Chemotherapy_Regimen	Fluorouracil/Melphalan/Tamoxifen|5-FU/L-PAM/TMX|PFT
C9944	Bleomycin_Doxorubicin_Mechlorethamine_Methotrexate_Vincristine	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Mechlorethamine/Methotrexate/Vincristine|BAMON|BLEO/DOX/MTX/NM/VCR
C9945	Dipyridamole_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Dipyridamole/Fluorouracil/Leucovorin Calcium|CF/DP/5-FU
C9946	Bleomycin_Doxorubicin_Streptozocin_Vincristine	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Streptozocin/Vincristine|BAVS|BLEO/DOX/SZC/VCR
C9947	Bleomycin_Cyclophosphamide_Etoposide_Prednisone_Procarbazine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Etoposide/Prednisone/Procarbazine|B-CEPP|BLEO/CTX/PCB/PRED/VP-16
C9948	Asparaginase_Cyclophosphamide_Cytarabine_Mercaptopurine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Mercaptopurine/Vincristine|ARA-C/ASP/CTX/MP/VCR
C9949	Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Thioguanine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Thioguanine/Vincristine|ARA-C/CTX/DM/DOX/TG/VCR
C9950	Dapsone_Trimetrexate-Glucuronate	Chemotherapy_Regimen	Dapsone/Trimetrexate Glucuronate|dapsone/TMTX
C9951	Carmustine_Dacarbazine_Hydroxyurea	Chemotherapy_Regimen	Carmustine/Dacarbazine/Hydroxyurea|BCNU/DTIC/HU|BHD
C9952	Carmustine_Dacarbazine_Hydroxyurea_Vincristine	Chemotherapy_Regimen	Carmustine/Dacarbazine/Hydroxyurea/Vincristine|BCNU/DTIC/HU/VCR|BHD-V
C9953	Cyclophosphamide_Doxorubicin_Fluorouracil_Fluoxymesterone_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Fluoxymesterone/Tamoxifen|CAFTH|CTX/DOX/5-FU/FXM/TMX
C9954	Pentamidine_Trimetrexate-Glucuronate	Chemotherapy_Regimen	Pentamidine/Trimetrexate Glucuronate|PAD/TMTX
C9955	Interferon-Beta_Zidovudine	Chemotherapy_Regimen	Interferon Beta/Zidovudine|IFN-B/ZDV
C9956	Carmustine_Procarbazine_Vincristine	Chemotherapy_Regimen	Carmustine/Procarbazine/Vincristine|BCNU/PCB/VCR|BVP
C9957	Cisplatin_Etoposide_Melphalan	Chemotherapy_Regimen	Cisplatin/Etoposide/Melphalan|CDDP/L-PAM/VP-16
C9958	Bleomycin_Methotrexate_Vinblastine	Chemotherapy_Regimen	Bleomycin/Methotrexate/Vinblastine|BLEO/MTX/VBL|BVM
C9959	Bleomycin_Mechlorethamine_Prednisone_Procarbazine_Vincristine	Chemotherapy_Regimen	Bleomycin/Mechlorethamine/Prednisone/Procarbazine/Vincristine|BLEO-MOPP|BLEO/NM/PCB/PRED/VCR
C9960	Cisplatin_Cytarabine_Dacarbazine_Hydroxyurea_Lomustine_Methylprednisolone_Procarbazine_Vincristine	Chemotherapy_Regimen	Cisplatin/Cytarabine/Dacarbazine/Hydroxyurea/Lomustine/Methylprednisolone/Procarbazine/Vincristine|ARA-C/CCNU/CDDP/DTIC/HU/MePRDL/PCB/VCR
C9961	Bleomycin_Cyclophosphamide_Lomustine_Prednisone_Procarbazine_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Lomustine/Prednisone/Procarbazine/Vincristine|BLEO-CCVPP|BLEO/CCNU/CTX/PCB/PRED/VCR
C9962	Lomustine_Prednisolone_Vincristine	Chemotherapy_Regimen	Lomustine/Prednisolone/Vincristine|CCNU/PRDL/VCR
C9963	Carmustine_Methotrexate_Procarbazine	Chemotherapy_Regimen	Carmustine/Methotrexate/Procarbazine|BCNU/MTX/PCB|BMP
C9964	Doxorubicin_Semustine_Streptozocin	Chemotherapy_Regimen	Doxorubicin/Semustine/Streptozocin|DOX/MeCCNU/SZC|SAM
C9965	Cisplatin_Cyclophosphamide_Doxorubicin_Triazinate	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Triazinate|CDDP/CTX/DOX/TZT|T-CAP
C9966	Doxorubicin_Fluoxymesterone_Tamoxifen_Thiotepa_Vinblastine	Chemotherapy_Regimen	Doxorubicin/Fluoxymesterone/Tamoxifen/Thiotepa/Vinblastine|DOX/FXM/TMX/TSPA/VBL|TAVTH
C9967	Cyclophosphamide_Sargramostim	Chemotherapy_Regimen	Cyclophosphamide/Sargramostim|CTX/GM-CSF
C9968	Interleukin-2_Thiotepa	Chemotherapy_Regimen	Interleukin-2/Thiotepa|IL-2/TSPA
C9969	Fluorouracil_Methotrexate_Prednisone_Thiotepa_Vinblastine	Chemotherapy_Regimen	Fluorouracil/Methotrexate/Prednisone/Thiotepa/Vinblastine|5-FU/MTX/PRED/TSPA/VBL|VTMFP
C9970	Doxorubicin_Mercaptopurine_Prednisone_Vincristine	Chemotherapy_Regimen	Doxorubicin/Mercaptopurine/Prednisone/Vincristine|BOMB|DOX/MP/PRED/VCR
C9971	Dacarbazine_Piritrexim	Chemotherapy_Regimen	Dacarbazine/Piritrexim|DTIC/piritrexim
C9972	Doxorubicin_Fluorouracil_Methotrexate_Prednisone_Thiotepa_Vinblastine	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Methotrexate/Prednisone/Thiotepa/Vinblastine|DOX/5-FU/MTX/PRED/TSPA/VBL|VTMAFP
C9973	Amiodarone_Doxorubicin_Etoposide	Chemotherapy_Regimen	Amiodarone/Doxorubicin/Etoposide|amiodarone/DOX/VP-16
C9974	Amiodarone_Doxorubicin	Chemotherapy_Regimen	Amiodarone/Doxorubicin|amiodarone/DOX
C9975	Cytarabine_Methotrexate_Vincristine	Chemotherapy_Regimen	Cytarabine/Methotrexate/Vincristine|ARA-C/MTX/VCR|CAMELEON
C9976	Mitomycin_Vinblastine	Chemotherapy_Regimen	Mitomycin/Vinblastine|MITO/VBL
C9977	Chlorambucil_Fludarabine	Chemotherapy_Regimen	Chlorambucil/Fludarabine|CLB/FAMP
C9978	Cyclophosphamide_Doxorubicin_Lomustine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Lomustine|CAC|CCNU/CTX/DOX
C9979	Cisplatin_Dacarbazine_Interleukin-2	Chemotherapy_Regimen	Cisplatin/Dacarbazine/Interleukin-2|CDDP/DTIC/IL-2
C9980	Fluorouracil_Leucovorin-Calcium_Semustine	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Semustine|CF/5-FU/MeCCNU
C9981	Fluorouracil_Levamisole	Chemotherapy_Regimen	Fluorouracil/Levamisole|5-FU/LEV|5FU/Levamisole
C9982	Cyclophosphamide_Doxorubicin_Fluorouracil_Methotrexate_Sargramostim_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Methotrexate/Sargramostim/Vincristine|CTX/DOX/5-FU/GM-CSF/MTX/VCR
C9983	Carboplatin_Cyclophosphamide_Sargramostim	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Sargramostim|CBDCA/CTX/GM-CSF
C9984	Lomustine_Prednisone_Vincristine	Chemotherapy_Regimen	Lomustine/Prednisone/Vincristine|CCNU-OP|CCNU/PRED/VCR
C9985	Carboplatin_Etoposide_Sargramostim	Chemotherapy_Regimen	Carboplatin/Etoposide/Sargramostim|CBDCA/GM-CSF/VP-16
C9986	Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide_Sargramostim	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Etoposide/Sargramostim|CDDP/CTX/DOX/GM-CSF/VP-16
C9987	Cyclophosphamide_Doxorubicin_Etoposide_Sargramostim	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Sargramostim|CTX/DOX/GM-CSF/VP-16
C9988	Dacarbazine_Doxorubicin_Ifosfamide_Sargramostim	Chemotherapy_Regimen	Dacarbazine/Doxorubicin/Ifosfamide/Sargramostim|DOX/DTIC/GM-CSF/IFF
C9989	Prednisone_Sargramostim_Vincristine	Chemotherapy_Regimen	Prednisone/Sargramostim/Vincristine|GM-CSF/PRED/VCR
C9990	Cisplatin_Cyclophosphamide_Etoposide_Interleukin-2	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Etoposide/Interleukin-2|CDDP/CTX/IL-2/VP-16
C9991	Melphalan_Sargramostim	Chemotherapy_Regimen	Melphalan/Sargramostim|GM-CSF/L-PAM
C9992	Doxorubicin_Ifosfamide_Lomustine	Chemotherapy_Regimen	Doxorubicin/Ifosfamide/Lomustine|CCNU/DOX/IFF
C9993	Fludarabine_Hydroxyurea	Chemotherapy_Regimen	Fludarabine/Hydroxyurea|FAMP/HU
C9994	Azacytidine_Cyclophosphamide_Cytarabine_Thioguanine_Vincristine	Chemotherapy_Regimen	Azacytidine/Cyclophosphamide/Cytarabine/Thioguanine/Vincristine|ARA-C/AZA/CTX/TG/VCR
C9995	Cyclophosphamide_Etoposide_Teniposide	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Teniposide|CTX/VM-26/VP-16
C9996	Daunorubicin_Etoposide_Prednisone_Teniposide_Thioguanine_Vincristine	Chemotherapy_Regimen	Daunorubicin/Etoposide/Prednisone/Teniposide/Thioguanine/Vincristine|DNR/PRED/TG/VCR/VM-26/VP-16
C9997	Cyclophosphamide_Daunorubicin_Etoposide_Prednisone_Teniposide_Thioguanine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Daunorubicin/Etoposide/Prednisone/Teniposide/Thioguanine/Vincristine|CTX/DNR/PRED/TG/VCR/VM-26/VP-16
C9998	Cyclophosphamide_Semustine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Semustine/Vincristine|COM|CTX/MeCCNU/VCR
C9999	Cyclophosphamide_Fluorouracil_Fluoxymesterone_Methotrexate_Prednisone_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Fluoxymesterone/Methotrexate/Prednisone/Tamoxifen|CMF(P)TH|CTX/5-FU/FXM/MTX/PRED/TMX
C10000	Cyclophosphamide_Fluoxymesterone_Mitolactol_Prednisone_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Fluoxymesterone/Mitolactol/Prednisone/Tamoxifen|CD(P)TH|CTX/DBD/FXM/PRED/TMX
C10001	Cyclophosphamide_Doxorubicin_Melphalan_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Melphalan/Vincristine|CONPADRI-I|CTX/DOX/L-PAM/VCR
C10002	Cyclophosphamide_Doxorubicin_Fluorouracil_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Methotrexate/Prednisone/Vincristine|CMFP-VA|CTX/DOX/5-FU/MTX/PRED/VCR
C10003	Methotrexate_Teniposide	Chemotherapy_Regimen	Methotrexate/Teniposide|MTX/VM-26
C10004	Cyclophosphamide_Fluorouracil_Methotrexate_Prednisone_Tamoxifen_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Methotrexate/Prednisone/Tamoxifen/Vincristine|CMFVP(T)|CTX/5-FU/MTX/PRED/TMX/VCR
C10005	Altretamine_Cyclophosphamide_Doxorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Altretamine/Cyclophosphamide/Doxorubicin/Prednisone/Vincristine|CHHOP|CTX/DOX/HMM/PRED/VCR
C10006	Altretamine_Cisplatin_Cyclophosphamide_Misonidazole	Chemotherapy_Regimen	Altretamine/Cisplatin/Cyclophosphamide/Misonidazole|CDDP/CTX/HMM/MNI|CHIPS
C10007	Bleomycin_Cytarabine_Methotrexate_Vincristine	Chemotherapy_Regimen	Bleomycin/Cytarabine/Methotrexate/Vincristine|ARA-C/BLEO/MTX/VCR|CytaBOM
C10008	Asparaginase_Methotrexate_Vincristine	Chemotherapy_Regimen	Asparaginase/Methotrexate/Vincristine|ASP/MTX/VCR
C10009	Prednisolone_Tamoxifen	Chemotherapy_Regimen	Prednisolone/Tamoxifen|PRDL/TMX
C10010	Asparaginase_Cyclophosphamide_Methotrexate_Prednisone_Vincristine_Zorubicin	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Methotrexate/Prednisone/Vincristine/Zorubicin|ASP/CTX/MTX/PRED/RBZ/VCR|CROPAM
C10011	Cyclophosphamide_Melphalan_Methylprednisolone	Chemotherapy_Regimen	Cyclophosphamide/Melphalan/Methylprednisolone|CTX/L-PAM/MePRDL
C10012	Cyclophosphamide_Prednisone_Vincristine_Zorubicin	Chemotherapy_Regimen	Cyclophosphamide/Prednisone/Vincristine/Zorubicin|CROP|CTX/PRED/VCR/RBZ
C10013	Doxorubicin_Fluoxymesterone_Mitolactol_Tamoxifen	Chemotherapy_Regimen	Doxorubicin/Fluoxymesterone/Mitolactol/Tamoxifen|DATH|DBD/DOX/FXM/TMX
C10014	Fluoxymesterone_Mitolactol_Mitoxantrone_Tamoxifen	Chemotherapy_Regimen	Fluoxymesterone/Mitolactol/Mitoxantrone/Tamoxifen|D(DHAD)TH|DBD/DHAD/FXM/TMX
C10015	Cisplatin_Dianhydrogalactitol_Doxorubicin	Chemotherapy_Regimen	Cisplatin/Dianhydrogalactitol/Doxorubicin|CDDP/DAG/DOX|DAP-II
C10016	Ancitabine-Hydrochloride_Daunorubicin_Mercaptopurine_Prednisolone	Chemotherapy_Regimen	Ancitabine Hydrochloride/Daunorubicin/Mercaptopurine/Prednisolone|CYC/DNR/MP/PRDL|DCCMP
C10017	Doxorubicin_Fluoxymesterone_Methotrexate_Mitolactol_Tamoxifen_Vincristine	Chemotherapy_Regimen	Doxorubicin/Fluoxymesterone/Methotrexate/Mitolactol/Tamoxifen/Vincristine|DAVTHML|DBD/DOX/FXM/MTX/TMX/VCR
C10018	Dianhydrogalactitol_Etoposide	Chemotherapy_Regimen	Dianhydrogalactitol/Etoposide|DAG/VP-16|DV
C10019	Azacytidine_Cytarabine_Daunorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Azacytidine/Cytarabine/Daunorubicin/Prednisone/Vincristine|ARA-C/AZA/DNR/PRED/VCR|DZAPO
C10020	Fluorouracil_Methotrexate_Mitolactol_Prednisone	Chemotherapy_Regimen	Fluorouracil/Methotrexate/Mitolactol/Prednisone|DBD/5-FU/MTX/PRED|DMFP
C10021	BCG_Cyclophosphamide_Doxorubicin_Tegafur	Chemotherapy_Regimen	BCG/Cyclophosphamide/Doxorubicin/Tegafur|BCG/CTX/DOX/FT|FAC-BCG
C10022	Fluorouracil_Razoxane_Semustine	Chemotherapy_Regimen	Fluorouracil/Razoxane/Semustine|5-FU/ICRF-159/MeCCNU|FIME
C10023	Doxorubicin_Mitomycin_Tegafur	Chemotherapy_Regimen	Doxorubicin/Mitomycin/Tegafur|DOX/FT/MITO|FURAM
C10024	Asparaginase_Methotrexate	Chemotherapy_Regimen	Asparaginase/Methotrexate|ASP/MTX
C10025	Asparaginase_Cytarabine_Doxorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Doxorubicin/Prednisone/Vincristine|ARA-C/ASP/DOX/PRED/VCR|LAPOCA
C10026	Chlorambucil_Prednisone_Vinblastine_Vincristine	Chemotherapy_Regimen	Chlorambucil/Prednisone/Vinblastine/Vincristine|CLB/PRED/VBL/VCR|LVVP
C10027	Fluorouracil_Mitomycin	Chemotherapy_Regimen	Fluorouracil/Mitomycin|5-FU/MITO|MF
C10028	Carmustine_Cyclophosphamide_Melphalan_Prednisone	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Melphalan/Prednisone|BCNU/CTX/L-PAM/PRED|MCBP
C10029	Doxorubicin_Lomustine_Mechlorethamine	Chemotherapy_Regimen	Doxorubicin/Lomustine/Mechlorethamine|CCNU/DOX/NM
C10030	Doxorubicin_Semustine	Chemotherapy_Regimen	Doxorubicin/Semustine|DOX/MeCCNU|MAD
C10031	Dactinomycin_Doxorubicin_Methotrexate_Vincristine	Chemotherapy_Regimen	Dactinomycin/Doxorubicin/Methotrexate/Vincristine|DACT/DOX/MTX/VCR|OMAD
C10032	Cyclophosphamide_Prednisolone_Teniposide	Chemotherapy_Regimen	Cyclophosphamide/Prednisolone/Teniposide|CTX/PRDL/VM-26
C10033	Fluorouracil_Melphalan	Chemotherapy_Regimen	Fluorouracil/Melphalan|5-FU/L-PAM|PF
C10034	Doxorubicin_Fluorouracil_Melphalan	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Melphalan|DOX/5-FU/L-PAM|PAF
C10035	Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Mercaptopurine/Methotrexate/Vincristine|MP/MTX/VCR|PIP
C10036	Cytarabine_Prednisone_Vincristine_Zorubicin	Chemotherapy_Regimen	Cytarabine/Prednisone/Vincristine/Zorubicin|ARA-C/PRED/VCR/RBZ|ROAP
C10037	Dacarbazine_Zorubicin	Chemotherapy_Regimen	Dacarbazine/Zorubicin|DTIC/RBZ|RUBIDIC
C10038	Methotrexate_Prednisone_Thioguanine_Vincristine	Chemotherapy_Regimen	Methotrexate/Prednisone/Thioguanine/Vincristine|MTX/PRED/TG/VCR|T-MOP
C10039	Amifostine_Cisplatin_Monoclonal-Antibody-R24	Chemotherapy_Regimen	Amifostine/Cisplatin/Monoclonal Antibody R24|CDDP/MOAB R24/WR-2721
C10040	Fluorouracil_Leucovorin-Calcium_Sargramostim	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Sargramostim|CF/5-FU/GM-CSF
C10041	Bleomycin_Cisplatin_Cyclophosphamide_Doxorubicin_Fluorouracil_Vincristine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Cyclophosphamide/Doxorubicin/Fluorouracil/Vincristine|BLEO/CDDP/CTX/DOX/5-FU/VCR|COAd/COB-5P
C10042	Bleomycin_Cyclophosphamide_Cytarabine_Doxorubicin_Etoposide_Methotrexate_Prednisone_Sargramostim_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Cytarabine/Doxorubicin/Etoposide/Methotrexate/Prednisone/Sargramostim/Vincristine|ARA-C/BLEO/CTX/DOX/GM-CSF/MTX/PRED/VCR/VP-16|ProMACE/CytaBOM/GM-CSF
C10043	Cisplatin_Cyclophosphamide_Fluorouracil_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Fluorouracil/Vincristine|CDDP/CTX/5-FU/VCR|CO-5P
C10044	Altretamine_Cyclophosphamide_Methotrexate	Chemotherapy_Regimen	Altretamine/Cyclophosphamide/Methotrexate|CMH|CTX/HMM/MTX
C10045	Cisplatin_Mitoguazone_Vinblastine	Chemotherapy_Regimen	Cisplatin/Mitoguazone/Vinblastine|CDDP/MGBG/VBL|CVeM
C10046	Ampligen_Interleukin-2	Chemotherapy_Regimen	Ampligen/Interleukin-2|ampligen/IL-2
C10047	Cisplatin_Cytarabine_Etoposide_Sargramostim	Chemotherapy_Regimen	Cisplatin/Cytarabine/Etoposide/Sargramostim|ARA-C/CDDP/GM-CSF/VP-16
C10048	Cyclophosphamide_Dexrazoxane_Doxorubicin_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dexrazoxane/Doxorubicin/Vincristine|ADR-529/CTX/DOX/VCR
C10049	Carmustine_Cyclophosphamide_Thiotepa_Vincristine	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Thiotepa/Vincristine|BCNU/CTX/TSPA/VCR|BTOC
C10050	Asparaginase_Idarubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Idarubicin/Prednisone/Vincristine|ASP/IDA/PRED/VCR
C10051	Carmustine_Triazinate	Chemotherapy_Regimen	Carmustine/Triazinate|BCNU/TZT|BT
C10052	Asparaginase_Cytarabine_Idarubicin	Chemotherapy_Regimen	Asparaginase/Cytarabine/Idarubicin|ARA-C/ASP/IDA
C10053	Cyclophosphamide_Doxorubicin_Fluorouracil_Prednisone	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Prednisone|CAFP|CTX/DOX/5-FU/PRED
C10054	Asparaginase_Cytarabine_Daunorubicin	Chemotherapy_Regimen	Asparaginase/Cytarabine/Daunorubicin|ARA-C/ASP/DNR
C10055	Cyclophosphamide_Doxorubicin_Folic-Acid_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Folic Acid/Methotrexate|CAMF|CTX/DOX/FA/MTX
C10056	Cyclophosphamide_Cytarabine_Daunorubicin_Dexamethasone_Thioguanine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Daunorubicin/Dexamethasone/Thioguanine/Vincristine|ARA-C/CTX/DM/DNR/TG/VCR
C10057	Fenretinide_Tamoxifen	Chemotherapy_Regimen	Fenretinide/Tamoxifen|Fenretinide + Tamoxifen|HPR/TMX
C10058	Altretamine_Cisplatin_Cyclophosphamide_Fluorouracil	Chemotherapy_Regimen	Altretamine/Cisplatin/Cyclophosphamide/Fluorouracil|CDDP/CTX/5-FU/HMM|CHEX-UP
C10059	Dactinomycin_Tumor-Necrosis-Factor	Chemotherapy_Regimen	Dactinomycin/Tumor Necrosis Factor|DACT/TNF
C10060	Cisplatin_Doxorubicin_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Fluorouracil/Leucovorin Calcium|CDDP/CF/DOX/5-FU
C10061	Altretamine_Lomustine_Methotrexate	Chemotherapy_Regimen	Altretamine/Lomustine/Methotrexate|CCNU/HMM/MTX|CHEXM
C10062	Cyclophosphamide_Doxorubicin_Melphalan_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Melphalan/Methotrexate/Vincristine|COMPADRI-V|CTX/DOX/L-PAM/MTX/VCR
C10063	Cyclophosphamide_Doxorubicin_Ethinyl-Estradiol_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Ethinyl Estradiol/Fluorouracil/Leucovorin Calcium|CALF-E|CF/CTX/DOX/ethinyl estradiol/5-FU
C10064	Cyclophosphamide_Fluorouracil_Leucovorin-Calcium_Mitoxantrone	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Leucovorin Calcium/Mitoxantrone|CF/CTX/DHAD/5-FU
C10065	Floxuridine_Leucovorin-Calcium	Chemotherapy_Regimen	Floxuridine/Leucovorin Calcium|CF/FUDR
C10066	Fluorouracil_Interferon-Beta	Chemotherapy_Regimen	Fluorouracil/Interferon Beta|5-FU/IFN-B
C10067	Cyclophosphamide_Doxorubicin_Fluorouracil_Streptozocin	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Streptozocin|CTX/DOX/5-FU/SZC|FAC-S
C10068	Octreotide_Tamoxifen	Chemotherapy_Regimen	Octreotide/Tamoxifen|SSTN/TMX
C10069	Melphalan_Methylprednisolone_Vincristine	Chemotherapy_Regimen	Melphalan/Methylprednisolone/Vincristine|L-PAM/MePRDL/VCR
C10070	Cyclophosphamide_Doxorubicin_Etoposide_Fluorouracil	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Fluorouracil|CTX/DOX/5-FU/VP-16|FACVP
C10071	Cyclophosphamide_Mercaptopurine_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Mercaptopurine/Prednisone/Vincristine|CTX/MP/PRED/VCR|VEMP
C10072	Cyclophosphamide_Dexrazoxane_Doxorubicin_Fluorouracil	Chemotherapy_Regimen	Cyclophosphamide/Dexrazoxane/Doxorubicin/Fluorouracil|ADR-529/CTX/DOX/5-FU
C10073	Doxorubicin_Fluorouracil_Mitomycin_Triazinate	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Mitomycin/Triazinate|DOX/5-FU/MITO/TZT|FAM-T
C10074	Asparaginase_Cytarabine_Sargramostim	Chemotherapy_Regimen	Asparaginase/Cytarabine/Sargramostim|ARA-C/ASP/GM-CSF
C10075	Etoposide_Methotrexate	Chemotherapy_Regimen	Etoposide/Methotrexate|MTX/VP-16|VMC
C10076	Doxorubicin_Fluorouracil_Triazinate	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Triazinate|DOX/5-FU/TZT|FAT
C10077	Interferon-Gamma_Levamisole	Chemotherapy_Regimen	Interferon Gamma/Levamisole|IFN-G/LEV
C10078	Cyclophosphamide_Doxorubicin_Fluorouracil_Sargramostim	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Sargramostim|CTX/DOX/5-FU/GM-CSF
C10079	Bleomycin_Procarbazine_Vinblastine	Chemotherapy_Regimen	Bleomycin/Procarbazine/Vinblastine|BLEO/PCB/VBL|VPB
C10080	Cytarabine_Doxorubicin_Mercaptopurine_Prednisone_Vincristine	Chemotherapy_Regimen	Cytarabine/Doxorubicin/Mercaptopurine/Prednisone/Vincristine|ARA-C/DOX/MP/PRED/VCR
C10081	Altretamine_Etoposide_Procarbazine	Chemotherapy_Regimen	Altretamine/Etoposide/Procarbazine|HMM/PCB/VP-16|VPH
C10082	Bleomycin_Cisplatin_Doxorubicin	Chemotherapy_Regimen	Bleomycin/Cisplatin/Doxorubicin|ABCX|BLEO/CDDP/DOX
C10083	Cisplatin_Doxorubicin_Fluorouracil_Vinblastine	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Fluorouracil/Vinblastine|CDDP/DOX/5-FU/VBL|FUVAC
C10084	Cytarabine_Doxorubicin_Mercaptopurine	Chemotherapy_Regimen	Cytarabine/Doxorubicin/Mercaptopurine|ARA-C/DOX/MP
C10085	Altretamine_Cyclophosphamide_Doxorubicin	Chemotherapy_Regimen	Altretamine/Cyclophosphamide/Doxorubicin|CTX/DOX/HMM|HAC
C10086	Cytarabine_Prednisone_Thioguanine_Vincristine	Chemotherapy_Regimen	Cytarabine/Prednisone/Thioguanine/Vincristine|ARA-C/PRED/TG/VCR|ATOP
C10087	Dacarbazine_Dactinomycin_Vincristine	Chemotherapy_Regimen	Dacarbazine/Dactinomycin/Vincristine|AVD|DACT/DTIC/VCR
C10088	Cytarabine_Zorubicin	Chemotherapy_Regimen	Cytarabine/Zorubicin|ARA-C/RBZ
C10089	Cisplatin_Cyclophosphamide_Cytarabine_Hydroxyurea_Lomustine_Methylprednisolone_Procarbazine_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Cytarabine/Hydroxyurea/Lomustine/Methylprednisolone/Procarbazine/Vincristine|ARA-C/CCNU/CDDP/CTX/HU/MePRDL/PCB/VCR
C10090	Doxorubicin_Methotrexate_Vinblastine	Chemotherapy_Regimen	Doxorubicin/Methotrexate/Vinblastine|AVM|DOX/MTX/VBL
C10091	Altretamine_Doxorubicin_Melphalan	Chemotherapy_Regimen	Altretamine/Doxorubicin/Melphalan|DOX/HMM/L-PAM|HAM
C10092	Altretamine_Doxorubicin_Methotrexate	Chemotherapy_Regimen	Altretamine/Doxorubicin/Methotrexate|DOX/HMM/MTX|HAM-II
C10093	Bleomycin_Cisplatin_Dacarbazine_Vinblastine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Dacarbazine/Vinblastine|BLEO/CDDP/DTIC/VBL|BVDD
C10094	Bleomycin_Prednisone_Vincristine	Chemotherapy_Regimen	Bleomycin/Prednisone/Vincristine|BLEO/PRED/VCR|BOP
C10095	Altretamine_Cisplatin	Chemotherapy_Regimen	Altretamine/Cisplatin|CDDP/HMM
C10096	Altretamine_Doxorubicin_Fluorouracil_Mitomycin	Chemotherapy_Regimen	Altretamine/Doxorubicin/Fluorouracil/Mitomycin|DOX/5-FU/HMM/MITO|HEXA-FAM
C10097	Carmustine_Cisplatin_Cyclophosphamide_Cytarabine_Hydroxyurea_Methylprednisolone_Procarbazine_Vincristine	Chemotherapy_Regimen	Carmustine/Cisplatin/Cyclophosphamide/Cytarabine/Hydroxyurea/Methylprednisolone/Procarbazine/Vincristine|ARA-C/BCNU/CDDP/CTX/HU/MePRDL/PCB/VCR
C10098	Amsacrine_Decitabine	Chemotherapy_Regimen	Amsacrine/Decitabine|AMSA/5-AZA-dCyd|AMSA/DAC
C10099	Decitabine_IDarubicin	Chemotherapy_Regimen	Decitabine/Idarubicin|5-AZA-dCyd/IDA|DAC/IDA
C10100	Cyclophosphamide_Fluorouracil_Methotrexate_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Methotrexate/Tamoxifen|CMFT|CTX/5-FU/MTX/TMX
C10101	Lomustine_Methotrexate_Vincristine	Chemotherapy_Regimen	Lomustine/Methotrexate/Vincristine|CCNU/MTX/VCR|CcOM
C10102	Asparaginase_Cyclophosphamide_Daunorubicin_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Daunorubicin/Methotrexate/Prednisone/Vincristine|ADCOMP|ASP/CTX/DNR/MTX/PRED/VCR
C10103	Bleomycin_Cisplatin_Mitoguazone_Vindesine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Mitoguazone/Vindesine|BLEO/CDDP/DAVA/MGBG|DVMB
C10104	Cisplatin_Cyclophosphamide_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Vincristine|CDDP/CTX/VCR
C10105	Cisplatin_Dacarbazine_Etoposide	Chemotherapy_Regimen	Cisplatin/Dacarbazine/Etoposide|CDDP/DTIC/VP-16|DVD
C10106	Cytarabine_Etoposide_Prednisone_Teniposide	Chemotherapy_Regimen	Cytarabine/Etoposide/Prednisone/Teniposide|ARA-C/PRED/VM-26/VP-16
C10107	Asparaginase_Cyclophosphamide_Doxorubicin_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Doxorubicin/Methotrexate/Prednisone/Vincristine|ASP/CTX/DOX/MTX/PRED/VCR|MACHO
C10108	Methotrexate_Prednisone_Procarbazine_Vincristine	Chemotherapy_Regimen	Methotrexate/Prednisone/Procarbazine/Vincristine|MTX/PCB/PRED/VCR
C10109	Doxorubicin_Prednisone_Teniposide	Chemotherapy_Regimen	Doxorubicin/Prednisone/Teniposide|DOX/PRED/VM-26|PATen
C10110	Cytarabine_Daunorubicin_Prednisone_Thioguanine	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Prednisone/Thioguanine|ARA-C/DNR/PRED/TG
C10111	Melphalan_Prednisone_Vincristine	Chemotherapy_Regimen	Melphalan/Prednisone/Vincristine|L-PAM/PRED/VCR
C10112	Biostim_Melphalan_Prednisone_Vincristine	Chemotherapy_Regimen	Biostim/Melphalan/Prednisone/Vincristine|biostim/L-PAM/PRED/VCR
C10113	Conjugated-Estrogens_Cyclophosphamide_Doxorubicin_Fluorouracil_Methotrexate_Tamoxifen	Chemotherapy_Regimen	Conjugated Estrogens/Cyclophosphamide/Doxorubicin/Fluorouracil/Methotrexate/Tamoxifen|CAMFTP|CTX/DOX/EST/5-FU/MTX/TMX
C10114	Biostim_Doxorubicin_Etoposide_Prednisone	Chemotherapy_Regimen	Biostim/Doxorubicin/Etoposide/Prednisone|biostim/DOX/PRED/VP-16
C10115	Doxorubicin_Fluorouracil_Methotrexate_Mitomycin	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Methotrexate/Mitomycin|DOX/5-FU/MITO/MTX|M-FAM
C10116	Daunorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Daunorubicin/Mercaptopurine/Methotrexate/Prednisone/Vincristine|DNR/MP/MTX/PRED/VCR|MTX-DOMP
C10117	Mitolactol_Mitoxantrone_Vincristine	Chemotherapy_Regimen	Mitolactol/Mitoxantrone/Vincristine|D(DHAD)V|DBD/DHAD/VCR
C10118	Doxorubicin_Thiotepa_Vinblastine	Chemotherapy_Regimen	Doxorubicin/Thiotepa/Vinblastine|DOX/TSPA/VBL|TAV
C10119	Cytarabine_Melphalan	Chemotherapy_Regimen	Cytarabine/Melphalan|AMA|ARA-C/L-PAM
C10120	Buthionine-Sulfoximine_Melphalan	Chemotherapy_Regimen	Buthionine Sulfoximine/Melphalan|BSO/L-PAM
C10121	Cyclophosphamide_Cytarabine_Etoposide_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Etoposide/Methotrexate/Prednisone/Vincristine|ARA-C/CTX/MTX/PRED/VCR/VP-16|MOPLACE
C10122	Lomustine_Mitolactol_Procarbazine_Thioguanine_Vincristine	Chemotherapy_Regimen	Lomustine/Mitolactol/Procarbazine/Thioguanine/Vincristine|CCNU/DBD/PCB/TG/VCR|TPDCV
C10123	Cisplatin_Cyclophosphamide_Doxorubicin_Misonidazole	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Misonidazole|CDDP/CTX/DOX/MNI|M-CAP
C10124	Bleomycin_Cyclophosphamide_Cytarabine_Doxorubicin_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Cytarabine/Doxorubicin/Methotrexate/Prednisone/Vincristine|ARA-C/BLEO/CTX/DOX/MTX/PRED/VCR|COMLA-Plus
C10125	Cytarabine_Dexamethasone_Methotrexate	Chemotherapy_Regimen	Cytarabine/Dexamethasone/Methotrexate|ARA-C/DM/MTX
C10126	Fluorouracil_Prednisone_Vincristine	Chemotherapy_Regimen	Fluorouracil/Prednisone/Vincristine|5-FU/PRED/VCR|VPF
C10127	Cisplatin_Fluorouracil_Mitomycin_Vincristine	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Mitomycin/Vincristine|CDDP/5-FU/MITO/VCR|MVPF
C10128	Doxorubicin_Fluorouracil_Melphalan_Tamoxifen	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Melphalan/Tamoxifen|DOX/5-FU/L-PAM/TMX|PAFT
C10129	Fluorouracil_Methotrexate_Vinblastine	Chemotherapy_Regimen	Fluorouracil/Methotrexate/Vinblastine|5-FU/MTX/VBL|MFV
C10130	Cisplatin_Hydrazine-Sulfate_Vinblastine	Chemotherapy_Regimen	Cisplatin/Hydrazine Sulfate/Vinblastine|CDDP/HDZ/VBL
C10131	Cyclophosphamide_Dexamethasone_Doxorubicin_Verapamil_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Doxorubicin/Verapamil/Vincristine|CTX/DM/DOX/VCR/VPAM|CVAD
C10132	Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide_Fluorouracil_Methotrexate_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Etoposide/Fluorouracil/Methotrexate/Vincristine|CDDP/CTX/DOX/5-FU/MTX/VCR/VP-16
C10133	Busulfan_Melphalan	Chemotherapy_Regimen	Busulfan/Melphalan|BU/L-PAM
C10134	Mechlorethamine_Methotrexate_Prednisone_Procarbazine_Vincristine	Chemotherapy_Regimen	Mechlorethamine/Methotrexate/Prednisone/Procarbazine/Vincristine|MTX/NM/PCB/PRED/VCR|echlorethamine/methotrexate/prednisone/procarbazine/vincristine
C10135	Cytarabine_Filgrastim	Chemotherapy_Regimen	Cytarabine/Filgrastim|ARA-C/G-CSF
C10136	Cisplatin_Etoposide_Mitoxantrone_Tamoxifen	Chemotherapy_Regimen	Cisplatin/Etoposide/Mitoxantrone/Tamoxifen|CDDP/DHAD/TMX/VP-16|TEMP
C10137	Etanidazole_Melphalan_Prednisone	Chemotherapy_Regimen	Etanidazole/Melphalan/Prednisone|L-PAM/PRED/SR-2508
C10138	Bleomycin_Cyclophosphamide_Doxorubicin_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Doxorubicin/Methotrexate/Prednisone/Vincristine|BLEO/CTX/DOX/MTX/PRED/VCR|MACOP-B
C10139	Cisplatin_Doxorubicin_Melphalan_Teniposide	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Melphalan/Teniposide|CDDP/DOX/L-PAM/VM-26|VAMP
C10140	Cytarabine_Daunorubicin_Etoposide_Thioguanine	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Etoposide/Thioguanine|ARA-C/DNR/TG/VP-16|V-TAD
C10141	Cisplatin_Etoposide_Interleukin-2	Chemotherapy_Regimen	Cisplatin/Etoposide/Interleukin-2|CDDP/IL-2/VP-16
C10142	Asparaginase_Cyclophosphamide_Cytarabine_Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Mercaptopurine/Methotrexate/Vincristine|ARA-C/ASP/CTX/MP/MTX/VCR
C10143	Doxorubicin_Etoposide_Prednisone	Chemotherapy_Regimen	Doxorubicin/Etoposide/Prednisone|DOX/PRED/VP-16
C10144	Trifluoperazine_Vinblastine	Chemotherapy_Regimen	Trifluoperazine/Vinblastine|TFPZ/VBL
C10145	BCG_Cyclophosphamide_Interleukin-2	Chemotherapy_Regimen	BCG/Cyclophosphamide/Interleukin-2|BCG/CTX/IL-2
C10146	Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide_Methotrexate_Vincristine_Vindesine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Etoposide/Methotrexate/Vincristine/Vindesine|CDDP/CTX/DAVA/DOX/MTX/VCR/VP-16
C10147	Dipyridamole_Vinblastine	Chemotherapy_Regimen	Dipyridamole/Vinblastine|DP/VBL
C10148	Bleomycin_Cyclophosphamide_Dexamethasone_Doxorubicin_Procarbazine_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Dexamethasone/Doxorubicin/Procarbazine/Vincristine|BLEO/CTX/DM/DOX/PCB/VCR|COD-BLAM IV
C10149	Bleomycin_Cisplatin_Mitomycin_Vindesine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Mitomycin/Vindesine|BEMP|BLEO/CDDP/DAVA/MITO
C10150	Chlorambucil_Etoposide_Lomustine	Chemotherapy_Regimen	Chlorambucil/Etoposide/Lomustine|CCNU/CLB/VP-16|CEC
C10151	Doxorubicin_Melphalan_Teniposide	Chemotherapy_Regimen	Doxorubicin/Melphalan/Teniposide|DOX/L-PAM/VM-26|MAV
C10152	Etoposide_Ifosfamide_Vindesine	Chemotherapy_Regimen	Etoposide/Ifosfamide/Vindesine|DAVA/IFF/VP-16|VPIV
C10153	Cyclophosphamide_Doxorubicin_Methotrexate_Vinblastine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Methotrexate/Vinblastine|CTX/DOX/MTX/VBL|M-CAVE
C10154	Hydrocortisone_Suramin	Chemotherapy_Regimen	Hydrocortisone/Suramin|HC/SUR|Suramin/HC
C10155	Cyclophosphamide_Dactinomycin_Doxorubicin_Hydroxyurea_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dactinomycin/Doxorubicin/Hydroxyurea/Methotrexate/Vincristine|CHAMOCA|CTX/DACT/DOX/HU/MTX/VCR
C10156	Cyclophosphamide_Cytarabine_Doxorubicin_Etoposide_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Doxorubicin/Etoposide/Methotrexate/Prednisone/Vincristine|AMOPLACE|ARA-C/CTX/DOX/MTX/PRED/VCR/VP-16
C10157	Altretamine_Carboplatin_Cyclophosphamide_Doxorubicin	Chemotherapy_Regimen	Altretamine/Carboplatin/Cyclophosphamide/Doxorubicin|CBDCA/CTX/DOX/HMM|CHAC-1
C10158	Cisplatin_Fluorouracil_Vinblastine	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Vinblastine|CDDP/5-FU/VBL|FVP
C10159	Cyclophosphamide_Dacarbazine_Dactinomycin_Doxorubicin_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dacarbazine/Dactinomycin/Doxorubicin/Vincristine|CTX/DACT/DOX/DTIC/VCR|VACAD
C10160	Doxorubicin_Fluorouracil_Vinblastine	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Vinblastine|DOX/5-FU/VBL|FUVA
C10161	Cyclophosphamide_Cytarabine_Prednisolone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Prednisolone/Vincristine|ARA-C/CTX/PRDL/VCR|COAP
C10162	Cisplatin_Dexamethasone_Etoposide	Chemotherapy_Regimen	Cisplatin/Dexamethasone/Etoposide|CDDP/DM/VP-16|CED
C10163	Cyclophosphamide_Prednisone	Chemotherapy_Regimen	Cyclophosphamide/Prednisone|CP|CTX/PRED
C10164	Bleomycin_Cisplatin_Doxorubicin_Etoposide	Chemotherapy_Regimen	Bleomycin/Cisplatin/Doxorubicin/Etoposide|BLEO/CDDP/DOX/VP-16|EBAP
C10165	Doxorubicin_Floxuridine_Mitomycin	Chemotherapy_Regimen	Doxorubicin/Floxuridine/Mitomycin|DOX/FUDR/MITO|FAM
C10166	Medroxyprogesterone_Mitomycin_Vinblastine	Chemotherapy_Regimen	Medroxyprogesterone/Mitomycin/Vinblastine|MITO/MPA/VBL|MVP
C10167	Procarbazine_Semustine_Vincristine	Chemotherapy_Regimen	Procarbazine/Semustine/Vincristine|MeCCNU/PCB/VCR
C10168	Doxorubicin_Mitomycin_Vindesine	Chemotherapy_Regimen	Doxorubicin/Mitomycin/Vindesine|DAVA/DOX/MITO|VAM
C10169	Cisplatin_Cyclophosphamide_Doxorubicin_Vindesine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Vindesine|CDDP/CTX/DAVA/DOX|PACE
C10170	Mercaptopurine_Methotrexate_Prednisolone_Vincristine	Chemotherapy_Regimen	Mercaptopurine/Methotrexate/Prednisolone/Vincristine|MP/MTX/PRDL/VCR|POMP
C10171	Bleomycin_Cyclophosphamide_Methotrexate_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Methotrexate/Vincristine|BLEO/CTX/MTX/VCR|COMB
C10172	Cisplatin_Fluorouracil	Chemotherapy_Regimen	Cisplatin/Fluorouracil|CDDP/5-FU|P-FU
C10173	Bleomycin_Cyclophosphamide_Cytarabine_Prednisone_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Cytarabine/Prednisone/Vincristine|ARA-C/BLEO/CTX/PRED/VCR|COAP-BLEO
C10174	Amsacrine_Cyclophosphamide_Hydroxyurea	Chemotherapy_Regimen	Amsacrine/Cyclophosphamide/Hydroxyurea|AMSA/CTX/HU|CMH
C10175	Carmustine_Cyclophosphamide_Dexamethasone	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Dexamethasone|BCNU/CTX/DM|CCD
C10176	Bleomycin_Fluorouracil_Methotrexate_Vincristine	Chemotherapy_Regimen	Bleomycin/Fluorouracil/Methotrexate/Vincristine|BLEO/5-FU/MTX/VCR|VBMF
C10177	Doxorubicin_Methotrexate_Vincristine	Chemotherapy_Regimen	Doxorubicin/Methotrexate/Vincristine|DOX/MTX/VCR|VAM
C10178	Cyclophosphamide_Doxorubicin_Vinblastine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Vinblastine|CTX/DOX/VBL|VAC
C10179	Cyclophosphamide_Dactinomycin_Vinblastine	Chemotherapy_Regimen	Cyclophosphamide/Dactinomycin/Vinblastine|CTX/DACT/VBL
C10180	Carmustine_Mercaptopurine	Chemotherapy_Regimen	Carmustine/Mercaptopurine|BCNU/MP
C10181	Doxorubicin_Etoposide_Mitomycin	Chemotherapy_Regimen	Doxorubicin/Etoposide/Mitomycin|DOX/MITO/VP-16|VAM
C10182	Etoposide_Ifosfamide	Chemotherapy_Regimen	Etoposide/Ifosfamide|EIM|IFF/VP-16
C10183	Chlorambucil_Prednisone_Procarbazine_Vinblastine	Chemotherapy_Regimen	Chlorambucil/Prednisone/Procarbazine/Vinblastine|CLB/PCB/PRED/VBL|ChlVPP
C10184	Cyclophosphamide_Lomustine_Prednisone_Procarbazine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Lomustine/Prednisone/Procarbazine/Vincristine|CCNU/CTX/PCB/PRED/VCR|COPP-CCNU
C10185	Mercaptopurine_Methotrexate_Methylprednisolone_Vincristine	Chemotherapy_Regimen	Mercaptopurine/Methotrexate/Methylprednisolone/Vincristine|MePRDL/MP/MTX/VCR|POMP
C10186	Aminoglutethimide_Danazol_Hydrocortisone_Tamoxifen	Chemotherapy_Regimen	Aminoglutethimide/Danazol/Hydrocortisone/Tamoxifen|AGT/DAN/HC/TMX|TAD
C10187	Aminoglutethimide_Danazol_Medroxyprogesterone_Tamoxifen	Chemotherapy_Regimen	Aminoglutethimide/Danazol/Medroxyprogesterone/Tamoxifen|AGT/DAN/MPA/TMX|POND
C10188	Bleomycin_Doxorubicin_Vincristine	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Vincristine|ABV|BLEO/DOX/VCR
C10189	Methotrexate_Vinblastine	Chemotherapy_Regimen	Methotrexate/Vinblastine|MTX/VBL|MV
C10190	Cyclophosphamide_Lomustine_Melphalan_Prednisolone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Lomustine/Melphalan/Prednisolone/Vincristine|CCNU/CTX/L-PAM/PRDL/VCR|CCVMP
C10191	Carboplatin_Vincristine	Chemotherapy_Regimen	Carboplatin/Vincristine|CBDCA/VCR
C10192	Carboplatin_Ifosfamide	Chemotherapy_Regimen	Carboplatin/Ifosfamide|CBDCA/IFF|IMP
C10193	Cyclophosphamide_Etoposide_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Methotrexate/Prednisone/Vincristine|CTX/MTX/PRED/VCR/VP-16|MOPLEC
C10194	Bleomycin_Mitomycin_Vindesine	Chemotherapy_Regimen	Bleomycin/Mitomycin/Vindesine|BEM|BLEO/DAVA/MITO
C10195	Dacarbazine_Doxorubicin_Ifosfamide	Chemotherapy_Regimen	Dacarbazine/Doxorubicin/Ifosfamide|DOX/DTIC/IFF
C10196	Cyclophosphamide_Doxorubicin_Etoposide_Interleukin-2	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Interleukin-2|CTX/DOX/IL-2/VP-16|LACE
C10197	Floxuridine_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Floxuridine/Fluorouracil/Leucovorin Calcium|CF/5-FU/FUDR
C10198	Epirubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Epirubicin/Prednisone/Vincristine|EOP|EPI/PRED/VCR
C10199	Carmustine_Cyclophosphamide_Doxorubicin_Melphalan_Prednisone_Vincristine	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Doxorubicin/Melphalan/Prednisone/Vincristine|BCNU/CTX/DOX/L-PAM/PRED/VCR|VBAPP/VMCPP|VMCPP alternating with VBAPP|VMCPP/VBAPP
C10200	Bleomycin_Idoxuridine	Chemotherapy_Regimen	Bleomycin/Idoxuridine|BLEO/IUDR
C10201	Cytarabine_Hydrocortisone_Methotrexate	Chemotherapy_Regimen	Cytarabine/Hydrocortisone/Methotrexate|ARA-C/HC/MTX|MHA
C10202	Etoposide_Tumor-Necrosis-Factor	Chemotherapy_Regimen	Etoposide/Tumor Necrosis Factor|TNF/VP-16
C10203	Doxorubicin_Fluorouracil_Leucovorin-Calcium_Mitomycin	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Leucovorin Calcium/Mitomycin|CF/DOX/5-FU/MITO|FAM-CF
C10204	Asparaginase_Doxorubicin_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Doxorubicin/Methotrexate/Prednisone/Vincristine|ASP/DOX/MTX/PRED/VCR
C10205	Doxorubicin_Fluorouracil_Methotrexate_Sargramostim	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Methotrexate/Sargramostim|DOX/5-FU/GM-CSF/MTX
C10206	Carboplatin_Cyclophosphamide_Sargramostim_Thiotepa	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Sargramostim/Thiotepa|CBDCA/CTX/GM-CSF/TSPA
C10207	Asparaginase_Cytarabine_Methotrexate_Vincristine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Methotrexate/Vincristine|ARA-C/ASP/MTX/VCR
C10208	Thiotepa_Vinblastine	Chemotherapy_Regimen	Thiotepa/Vinblastine|TSPA/VBL
C10209	Amifostine_Cisplatin_Interleukin-2	Chemotherapy_Regimen	Amifostine/Cisplatin/Interleukin-2|CDDP/IL-2/WR-2721
C10210	Amifostine_Thiotepa	Chemotherapy_Regimen	Amifostine/Thiotepa|TSPA/WR-2721
C10211	Cyclophosphamide_Mitoxantrone_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Mitoxantrone/Prednisone/Vincristine|CNOP|CTX/DHAD/PRED/VCR
C10212	Cyclophosphamide_Doxorubicin_Fluorouracil_Fluoxymesterone_Thiotepa_Vinblastine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Fluoxymesterone/Thiotepa/Vinblastine|CAF/TsAVbH|CTX/DOX/5-FU/FXM/TSPA/VBL
C10213	Asparaginase_Cyclophosphamide_Cytarabine_Methotrexate_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Methotrexate/Vincristine|ARA-C/ASP/CTX/MTX/VCR
C10214	Cyclophosphamide_Fluorouracil_Fluoxymesterone_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Fluoxymesterone/Methotrexate|CMFH|CTX/5-FU/FXM/MTX
C10215	Cyclophosphamide_Doxorubicin_Prednisone_Teniposide_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Prednisone/Teniposide/Vincristine|CAVPE|CTX/DOX/PRED/VCR/VM-26
C10216	Doxorubicin_Etoposide_Prednisone_Vincristine	Chemotherapy_Regimen	Doxorubicin/Etoposide/Prednisone/Vincristine|AOPE|DOX/PRED/VCR/VP-16
C10217	Bleomycin_Carmustine_Etoposide_Methotrexate_Prednisone	Chemotherapy_Regimen	Bleomycin/Carmustine/Etoposide/Methotrexate/Prednisone|BCNU/BLEO/MTX/PRED/VP-16
C10218	Carmustine_Cyclophosphamide_Thiotepa	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Thiotepa|BCNU/CTX/TSPA
C10219	Bleomycin_Vincristine	Chemotherapy_Regimen	Bleomycin/Vincristine|BLEO/VCR|BO
C10220	Bleomycin_Vinblastine	Chemotherapy_Regimen	Bleomycin/Vinblastine|BLEO/VBL
C10221	Dactinomycin_Etoposide_Ifosfamide_Vincristine	Chemotherapy_Regimen	Dactinomycin/Etoposide/Ifosfamide/Vincristine|DACT/IFF/VCR/VP-16
C10222	Cyclophosphamide_Fluorouracil_Fluoxymesterone_Methotrexate_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Fluoxymesterone/Methotrexate/Tamoxifen|CTX/5-FU/FXM/MTX/TMX
C10223	Cyclophosphamide_Doxorubicin_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Leucovorin Calcium|CF/CTX/DOX/5-FU|FLAC
C10224	Cisplatin_Melphalan_Teniposide	Chemotherapy_Regimen	Cisplatin/Melphalan/Teniposide|CDDP/L-PAM/VM-26
C10225	Asparaginase_Doxorubicin_Vincristine	Chemotherapy_Regimen	Asparaginase/Doxorubicin/Vincristine|ASP/DOX/VCR
C10226	Caffeine_Cisplatin_Cytarabine	Chemotherapy_Regimen	Caffeine/Cisplatin/Cytarabine|ARA-C/CAF/CDDP
C10227	Cyclophosphamide_Doxorubicin_Fluorouracil_Leucovorin-Calcium_Sargramostim	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Leucovorin Calcium/Sargramostim|CF/CTX/DOX/5-FU/GM-CSF
C10228	Cisplatin_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Paclitaxel|CDDP/TAX
C10229	Cyclophosphamide_Fluorouracil_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Tamoxifen|CTX/5-FU/TMX
C10230	Cytarabine_Etoposide_Methylprednisolone	Chemotherapy_Regimen	Cytarabine/Etoposide/Methylprednisolone|ARA-C/MePRDL/VP-16
C10231	Etoposide_Mitoguazone_Mitoxantrone_Vinblastine	Chemotherapy_Regimen	Etoposide/Mitoguazone/Mitoxantrone/Vinblastine|DHAD/MGBG/VBL/VP-16
C10232	Fluorouracil_Interleukin-1-Beta	Chemotherapy_Regimen	Fluorouracil/Interleukin-1-Beta|5-FU/IL-1B
C10233	Amifostine_Carboplatin	Chemotherapy_Regimen	Amifostine/Carboplatin|CBDCA/WR-2721
C10234	Bleomycin_Cisplatin_Cyclophosphamide_Dactinomycin_Vinblastine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Cyclophosphamide/Dactinomycin/Vinblastine|BLEO/CDDP/CTX/DACT/VBL|VAB-V
C10235	Cisplatin_Fluorouracil_Interleukin-2	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Interleukin-2|CDDP/5-FU/IL-2
C10236	Cisplatin_Mitoxantrone	Chemotherapy_Regimen	Cisplatin/Mitoxantrone|CDDP/DHAD
C10237	Cyclophosphamide_Interleukin-2	Chemotherapy_Regimen	Cyclophosphamide/Interleukin-2|CTX/IL-2
C10238	Cytarabine_Daunorubicin_Dexamethasone_Etoposide_Thioguanine	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Dexamethasone/Etoposide/Thioguanine|ARA-C/DM/DNR/TG/VP-16
C10239	Cytarabine_Etoposide	Chemotherapy_Regimen	Cytarabine/Etoposide|ARA-C/VP-16
C10240	Cytarabine_Mitoxantrone_Thioguanine	Chemotherapy_Regimen	Cytarabine/Mitoxantrone/Thioguanine|ARA-C/DHAD/TG
C10241	Cytarabine_Mitoxantrone_Thioguanine_Vincristine	Chemotherapy_Regimen	Cytarabine/Mitoxantrone/Thioguanine/Vincristine|ARA-C/DHAD/TG/VCR
C10242	Etoposide_Mitomycin	Chemotherapy_Regimen	Etoposide/Mitomycin|MITO/VP-16
C10243	Fluorouracil_PALA	Chemotherapy_Regimen	Fluorouracil/PALA|5-FU/PALA
C10244	Ifosfamide_Mitoxantrone	Chemotherapy_Regimen	Ifosfamide/Mitoxantrone|DHAD/IFF
C10245	Interferon-Gamma_Tumor-Necrosis-Factor	Chemotherapy_Regimen	Interferon Gamma/Tumor Necrosis Factor|IFN-G/TNF
C10246	Interleukin-2_Lymphokine-Activated-Killer-Cells	Chemotherapy_Regimen	Interleukin-2/Lymphokine-Activated Killer Cells|IL-2/LAK|IL2/LAK
C10247	Asparaginase_Cytarabine_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Prednisone/Vincristine|AOPA|ARA-C/ASP/PRED/VCR
C10248	Asparaginase_Cyclophosphamide_Cytarabine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine|ARA-C/ASP/CTX
C10249	Fluorouracil_Methotrexate_PALA	Chemotherapy_Regimen	Fluorouracil/Methotrexate/PALA|5-FU/MTX/PALA
C10250	Carboplatin_Vinblastine	Chemotherapy_Regimen	Carboplatin/Vinblastine|CBDCA/VBL
C10251	Cisplatin_Mitomycin_Triazinate	Chemotherapy_Regimen	Cisplatin/Mitomycin/Triazinate|CDDP/MITO/TZT
C10252	Cyclophosphamide_Cytarabine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine|ARA-C/CTX
C10253	Cytarabine_Teniposide	Chemotherapy_Regimen	Cytarabine/Teniposide|ARA-C/VM-26
C10254	Etoposide_Mitoxantrone_Thiotepa	Chemotherapy_Regimen	Etoposide/Mitoxantrone/Thiotepa|DHAD/TSPA/VP-16
C10255	Fluorouracil_Semustine	Chemotherapy_Regimen	Fluorouracil/Semustine|5-FU/MeCCNU
C10256	Mercaptopurine_Methotrexate	Chemotherapy_Regimen	Mercaptopurine/Methotrexate|MP/MTX
C10257	Mercaptopurine_Prednisone_Vincristine	Chemotherapy_Regimen	Mercaptopurine/Prednisone/Vincristine|MP/PRED/VCR
C10258	Fludarabine_Prednisone	Chemotherapy_Regimen	Fludarabine/Prednisone|FAMP/PRED
C10259	Cyclophosphamide_Diethylstilbestrol_Fluorouracil_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Diethylstilbestrol/Fluorouracil/Methotrexate|CTX/DES/5-FU/MTX
C10260	Cisplatin_Etoposide_Mitoguazone	Chemotherapy_Regimen	Cisplatin/Etoposide/Mitoguazone|CDDP/MGBG/VP-16|CVM|CVpMG
C10261	Cisplatin_Mitomycin_Vinblastine	Chemotherapy_Regimen	Cisplatin/Mitomycin/Vinblastine|CDDP/MITO/VBL|CVeMi|MiPV|PVeMi
C10262	Cisplatin_Mitomycin_Vindesine	Chemotherapy_Regimen	Cisplatin/Mitomycin/Vindesine|CDDP/DAVA/MITO|MVP|MiPE|MiViP
C10263	Cisplatin_Vinblastine	Chemotherapy_Regimen	Cisplatin/Vinblastine|CDDP/VBL|PVe|V-DDP|VP
C10264	Cisplatin_Vindesine	Chemotherapy_Regimen	Cisplatin/Vindesine|CDDP/DAVA|Vind-Plat
C10265	Cisplatin_Cyclophosphamide_Doxorubicin	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin|CAP-I|CAP-II|CDDP/CTX/DOX|CISCA-II|PAC
C10266	Cyclophosphamide_Doxorubicin_Lomustine_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Lomustine/Prednisone/Vincristine|CCNU/CTX/DOX/PRED/VCR|COPAC
C10267	Bleomycin_Dacarbazine_Doxorubicin_Mechlorethamine_Prednisone_Procarbazine_Vinblastine_Vincristine	Chemotherapy_Regimen	Bleomycin/Dacarbazine/Doxorubicin/Mechlorethamine/Prednisone/Procarbazine/Vinblastine/Vincristine|ABVD/MOPP|BLEO/DOX/DTIC/NM/PCB/PRED/VBL/VCR|MA/MA|MOPP alternating with ABVD|MOPP/ABVD
C10268	Cisplatin_Cyclophosphamide_Etoposide	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Etoposide|CDDP/CTX/VP-16|CVP|PCE|PVC|VCP-1
C10269	Cisplatin_Cyclophosphamide_Etoposide_Lomustine_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Etoposide/Lomustine/Vincristine|CCNU/CDDP/CTX/VCR/VP-16|CCVVP
C10270	Cyclophosphamide_Cytarabine_Prednisone_Thioguanine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Prednisone/Thioguanine/Vincristine|ARA-C/CTX/PRED/TG/VCR|T-COAP
C10271	Cytarabine_Daunorubicin	Chemotherapy_Regimen	Cytarabine/Daunorubicin|ARA-C/DNR|CAD|DA
C10272	Cytarabine_Doxorubicin_Etoposide_Thioguanine	Chemotherapy_Regimen	Cytarabine/Doxorubicin/Etoposide/Thioguanine|ARA-C/DOX/TG/VP-16|VATA-II
C10273	Cytarabine_Etoposide_Methotrexate	Chemotherapy_Regimen	Cytarabine/Etoposide/Methotrexate|ARA-C/MTX/VP-16|EMCC (EMC2)|MACE
C10274	Doxorubicin_Fluorouracil	Chemotherapy_Regimen	Doxorubicin/Fluorouracil|AFA|DOX/5-FU
C10275	Cyclophosphamide_Doxorubicin_Etoposide_Lomustine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Lomustine/Vincristine|CCNU/CTX/DOX/VCR/VP-16
C10276	Cytarabine_Methotrexate	Chemotherapy_Regimen	Cytarabine/Methotrexate|ARA-C/MTX|CCM
C10277	Cytarabine_Thioguanine	Chemotherapy_Regimen	Cytarabine/Thioguanine|ARA-C/TG|TA
C10278	Doxorubicin_Etoposide_Methotrexate	Chemotherapy_Regimen	Doxorubicin/Etoposide/Methotrexate|AMV|DOX/MTX/VP-16
C10279	Doxorubicin_Fluorouracil_Mitomycin_Vincristine	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Mitomycin/Vincristine|DOX/5-FU/MITO/VCR|VFAM
C10280	Doxorubicin_Fluorouracil_Semustine	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Semustine|DOX/5-FU/MeCCNU|MEFA
C10281	Doxorubicin_Vincristine	Chemotherapy_Regimen	Doxorubicin/Vincristine|AO|DOX/VCR
C10282	Altretamine_Etoposide_Methotrexate	Chemotherapy_Regimen	Altretamine/Etoposide/Methotrexate|HMM/MTX/VP-16|MVH|VHM
C10283	Fluorouracil_Methotrexate	Chemotherapy_Regimen	Fluorouracil/Methotrexate|5-FU/MTX|MF|MeF
C10284	Altretamine_Cisplatin_Cyclophosphamide	Chemotherapy_Regimen	Altretamine/Cisplatin/Cyclophosphamide|CDDP/CTX/HMM|CHD
C10285	Cisplatin_Methotrexate	Chemotherapy_Regimen	Cisplatin/Methotrexate|CDDP/MTX
C10286	Cisplatin_Ifosfamide	Chemotherapy_Regimen	Cisplatin/Ifosfamide|CDDP/IFF
C10287	Altretamine_Doxorubicin_Fluoxymesterone_Methotrexate_Mitolactol_Prednisone_Tamoxifen_Vincristine	Chemotherapy_Regimen	Altretamine/Doxorubicin/Fluoxymesterone/Methotrexate/Mitolactol/Prednisone/Tamoxifen/Vincristine|DBD/DOX/FXM/HMM/MTX/PRED/TMX/VCR
C10288	Altretamine_Cyclophosphamide_Doxorubicin_Fluorouracil_Fluoxymesterone_Methotrexate_Prednisone_Tamoxifen_Vinblastine	Chemotherapy_Regimen	Altretamine/Cyclophosphamide/Doxorubicin/Fluorouracil/Fluoxymesterone/Methotrexate/Prednisone/Tamoxifen/Vinblastine|CTX/DOX/5-FU/FXM/HMM/MTX/PRED/TMX/VBL
C10289	Carboplatin_Etoposide	Chemotherapy_Regimen	Carboplatin/Etoposide|CBDCA/VP-16
C10290	Carboplatin_Fluorouracil_Methotrexate	Chemotherapy_Regimen	Carboplatin/Fluorouracil/Methotrexate|CBDCA/5-FU/MTX
C10291	Asparaginase_Cytarabine_Daunorubicin_Prednisone_Teniposide_Vincristine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Daunorubicin/Prednisone/Teniposide/Vincristine|ARA-C/ASP/DNR/PRED/VCR/VM-26
C10292	Cisplatin_Ifosfamide_Vinblastine	Chemotherapy_Regimen	Cisplatin/Ifosfamide/Vinblastine|CDDP/IFF/VBL
C10293	Etoposide_Thiotepa	Chemotherapy_Regimen	Etoposide/Thiotepa|TSPA/VP-16
C10294	Amphotericin-B_Flucytosine	Chemotherapy_Regimen	Amphotericin B/Flucytosine|Amphotericin B/5-FC
C10295	Doxorubicin_Ethiodized-Oil	Chemotherapy_Regimen	Doxorubicin/Ethiodized Oil|DOX/Ethiodized Oil
C10296	Cisplatin_Doxorubicin_Etoposide_Fluorouracil_Mitomycin	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Etoposide/Fluorouracil/Mitomycin|CDDP/DOX/5-FU/MITO/VP-16
C10297	Mechlorethamine_Prednisone_Procarbazine_Sargramostim_Vincristine	Chemotherapy_Regimen	Mechlorethamine/Prednisone/Procarbazine/Sargramostim/Vincristine|GM-CSF/NM/PCB/PRED/VCR
C10298	Asparaginase_Daunorubicin_Prednisolone_Vincristine	Chemotherapy_Regimen	Asparaginase/Daunorubicin/Prednisolone/Vincristine|ASP/DNR/PRDL/VCR
C10299	Asparaginase_Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Vincristine|ARA-C/ASP/CTX/DM/DOX/VCR
C10300	Asparaginase_Cyclophosphamide_Cytarabine_Mercaptopurine_Methotrexate	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Mercaptopurine/Methotrexate|ARA-C/ASP/CTX/MP/MTX
C10301	Asparaginase_Cytarabine_Mercaptopurine_Methotrexate_Prednisolone_Teniposide_Vincristine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Mercaptopurine/Methotrexate/Prednisolone/Teniposide/Vincristine|ARA-C/ASP/MP/MTX/PRDL/VCR/VM-26
C10302	Daunorubicin_Dexamethasone_Ifosfamide_Methotrexate_Thioguanine_Vindesine	Chemotherapy_Regimen	Daunorubicin/Dexamethasone/Ifosfamide/Methotrexate/Thioguanine/Vindesine|DAVA/DM/DNR/IFF/MTX/TG
C10303	Carmustine_Cisplatin_Dacarbazine	Chemotherapy_Regimen	Carmustine/Cisplatin/Dacarbazine|BCNU/CDDP/DTIC
C10304	Cisplatin_Tamoxifen	Chemotherapy_Regimen	Cisplatin/Tamoxifen|CDDP/TMX
C10305	Eflornithine_Mitoguazone	Chemotherapy_Regimen	Eflornithine/Mitoguazone|DFMO/MGBG
C10306	Asparaginase_Cytarabine_Mercaptopurine_Methotrexate_Prednisone_Teniposide	Chemotherapy_Regimen	Asparaginase/Cytarabine/Mercaptopurine/Methotrexate/Prednisone/Teniposide|ARA-C/ASP/MP/MTX/PRED/VM-26
C10307	Amiodarone_Vinblastine	Chemotherapy_Regimen	Amiodarone/Vinblastine|Amiodarone/VBL
C10308	Doxorubicin_Quinidine	Chemotherapy_Regimen	Doxorubicin/Quinidine|DOX/QND
C10309	Quinidine_Vinblastine	Chemotherapy_Regimen	Quinidine/Vinblastine|QND/VBL
C10310	BCG_Fluorouracil	Chemotherapy_Regimen	BCG/Fluorouracil|BCG/5-FU
C10311	Bropirimine_Tamoxifen	Chemotherapy_Regimen	Bropirimine/Tamoxifen|ABPP/TAX
C10312	Acyclovir_Zidovudine	Chemotherapy_Regimen	Acyclovir/Zidovudine|ACV/ZDV
C10313	Cyclophosphamide_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Vincristine|CTX/VCR
C10314	Dactinomycin_Vincristine	Chemotherapy_Regimen	Dactinomycin/Vincristine|DACT/VCR
C10315	Dactinomycin_Doxorubicin_Vincristine	Chemotherapy_Regimen	Dactinomycin/Doxorubicin/Vincristine|DACT/DOX/VCR
C10316	Amifostine_Cisplatin	Chemotherapy_Regimen	Amifostine/Cisplatin|CDDP/WR-2721
C10317	Lomustine_Mitoxantrone_Vinblastine	Chemotherapy_Regimen	Lomustine/Mitoxantrone/Vinblastine|CCNU/DHAD/VBL
C10318	Dexamethasone_Metoclopramide_Midazolam	Chemotherapy_Regimen	Dexamethasone/Metoclopramide/Midazolam|DM/MCP/Midazolam
C10319	Cisplatin_Cyclophosphamide_10-EdAM	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/10-EdAM|CDDP/CTX/EDAM|Cisplatin/Cyclophosphamide/Edatrexate
C10320	Bleomycin_Cyclophosphamide_Dexamethasone_Doxorubicin_Methotrexate_Sargramostim_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Dexamethasone/Doxorubicin/Methotrexate/Sargramostim/Vincristine|BLEO/CTX/DM/DOX/GM-CSF/MTX/VCR
C10321	Cyclophosphamide_Doxorubicin_Sargramostim	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Sargramostim|CTX/DOX/GM-CSF
C10322	Carmustine_Cyclophosphamide_Etoposide_Filgrastim	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Etoposide/Filgrastim|BCNU/CTX/G-CSF/VP-16
C10323	Cyclophosphamide_Doxorubicin_Etoposide_Filgrastim	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Filgrastim|CTX/DOX/G-CSF/VP-16
C10324	Methotrexate_Vincristine	Chemotherapy_Regimen	Methotrexate/Vincristine|MTX/VCR
C10325	Cisplatin_Vincristine	Chemotherapy_Regimen	Cisplatin/Vincristine|CDDP/VCR
C10326	Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide_Methotrexate_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Etoposide/Methotrexate/Vincristine|CDDP/CTX/DOX/MTX/VCR/VP-16
C10327	Carmustine_Cyclophosphamide_Melphalan_Misonidazole_Prednisone	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Melphalan/Misonidazole/Prednisone|BCNU/CTX/L-PAM/MNI/PRED
C10328	Cytarabine_Hydroxyurea	Chemotherapy_Regimen	Cytarabine/Hydroxyurea|ARA-C/HU
C10329	Fluorouracil_Hydroxyurea	Chemotherapy_Regimen	Fluorouracil/Hydroxyurea|5-FU/HU
C10330	Melphalan_Misonidazole	Chemotherapy_Regimen	Melphalan/Misonidazole|L-PAM/MNI
C10331	Cyclophosphamide_Interleukin-2_Tumor-Infiltrating-Lymphocytes	Chemotherapy_Regimen	Cyclophosphamide/Interleukin-2/Tumor Infiltrating Lymphocytes|CTX/IL-2/TIL
C10332	Doxorubicin_Fluorouracil_Thiotepa	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Thiotepa|DOX/5-FU/TSPA
C10333	Cyclophosphamide_Doxorubicin_Fluorouracil_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Tamoxifen|CTX/DOX/5-FU/TMX
C10334	Mitoxantrone_Thiotepa	Chemotherapy_Regimen	Mitoxantrone/Thiotepa|DHAD/TSPA
C10335	Cyclophosphamide_Daunorubicin_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Daunorubicin/Methotrexate/Prednisone/Vincristine|CTX/DNR/MTX/PRED/VCR
C10336	Cyclophosphamide_Thioguanine	Chemotherapy_Regimen	Cyclophosphamide/Thioguanine|CTX/TG
C10337	Daunorubicin_Hydroxyurea	Chemotherapy_Regimen	Daunorubicin/Hydroxyurea|DNR/HU
C10338	Carmustine_Methotrexate	Chemotherapy_Regimen	Carmustine/Methotrexate|BCNU/MTX
C10339	Cytarabine_Vincristine	Chemotherapy_Regimen	Cytarabine/Vincristine|ARA-C/VCR
C10340	Etoposide_Ifosfamide_Mitoxantrone	Chemotherapy_Regimen	Etoposide/Ifosfamide/Mitoxantrone|DHAD/IFF/VP-16
C10341	Thiotepa_Vincristine	Chemotherapy_Regimen	Thiotepa/Vincristine|TSPA/VCR
C10342	Cisplatin_Cyclophosphamide_Etoposide_Thiotepa_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Etoposide/Thiotepa/Vincristine|CDDP/CTX/TSPA/VCR/VP-16
C10343	Fluorouracil_Leucovorin-Calcium_PALA	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/PALA|CF/5-FU/PALA
C10344	Lomustine_Mitolactol_Procarbazine_Thioguanine	Chemotherapy_Regimen	Lomustine/Mitolactol/Procarbazine/Thioguanine|CCNU/DBD/PCB/TG
C10345	Carboplatin_Etoposide_Ifosfamide	Chemotherapy_Regimen	Carboplatin/Etoposide/Ifosfamide|CBDCA/IFF/VP-16|ICE
C10346	Dexamethasone_Doxorubicin_Verapamil_Vincristine	Chemotherapy_Regimen	Dexamethasone/Doxorubicin/Verapamil/Vincristine|DM/DOX/VCR/VPAM
C10347	Doxorubicin_Fluorouracil_Tamoxifen_Thiotepa	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Tamoxifen/Thiotepa|DOX/5-FU/TMX/TSPA
C10348	Fluorouracil_Methotrexate_Tamoxifen_Thiotepa	Chemotherapy_Regimen	Fluorouracil/Methotrexate/Tamoxifen/Thiotepa|5-FU/MTX/TMX/TSPA
C10349	Cisplatin_Etoposide_Sargramostim	Chemotherapy_Regimen	Cisplatin/Etoposide/Sargramostim|CDDP/GM-CSF/VP-16
C10350	Cisplatin_Doxorubicin_Etoposide_Ifosfamide	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Etoposide/Ifosfamide|CDDP/DOX/IFF/VP-16
C10351	Cyclophosphamide_Interleukin-2_Lymphokine-Activated-Killer-Cells	Chemotherapy_Regimen	Cyclophosphamide/Interleukin-2/Lymphokine-Activated Killer Cells|CTX/IL-2/LAK
C10352	Edatrexate_Mitomycin_Vinblastine	Chemotherapy_Regimen	Edatrexate/Mitomycin/Vinblastine|EDAM/MITO/VBL
C10353	Cyclophosphamide_Doxorubicin_Fluorouracil_Goserelin_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Goserelin/Tamoxifen|CTX/DOX/5-FU/TMX/ZDX
C10354	Cyclophosphamide_Doxorubicin_Fluorouracil_Goserelin	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Goserelin|CTX/DOX/5-FU/ZDX
C10355	Carmustine_Tiazofurin	Chemotherapy_Regimen	Carmustine/Tiazofurin|BCNU/TCAR
C10356	Cisplatin_Fluorouracil_Leucovorin-Calcium_Mitomycin	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Leucovorin Calcium/Mitomycin|CDDP/CF/5-FU/MITO
C10357	Asparaginase_Cyclophosphamide_Cytarabine_Thioguanine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Thioguanine/Vincristine|ARA-C/ASP/CTX/TG/VCR
C10358	Interferon-Gamma_Sargramostim	Chemotherapy_Regimen	Interferon Gamma/Sargramostim|GM-CSF/IFN-G
C10359	Cytarabine_Daunorubicin_Etoposide_Prednisolone_Thioguanine_Vincristine	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Etoposide/Prednisolone/Thioguanine/Vincristine|ARA-C/DNR/PRDL/TG/VCR/VP-16
C10360	Cyclophosphamide_Doxorubicin_Etoposide_Filgrastim_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Filgrastim/Prednisone/Vincristine|CTX/DOX/G-CSF/PRED/VCR/VP-16
C10361	Carboplatin_Cisplatin_Etoposide	Chemotherapy_Regimen	Carboplatin/Cisplatin/Etoposide|CBDCA/CDDP/VP-16
C10362	Asparaginase_Cyclophosphamide_Cytarabine_Idarubicin_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Idarubicin/Methotrexate/Prednisone/Vincristine|ARA-C/ASP/CTX/IDA/MTX/PRED/VCR
C10363	Dactinomycin_Idarubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Dactinomycin/Idarubicin/Mercaptopurine/Methotrexate/Prednisone/Vincristine|DACT/IDA/MP/MTX/PRED/VCR
C10364	Carmustine_Cyclophosphamide_Dactinomycin_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Dactinomycin/Mercaptopurine/Methotrexate/Prednisone/Vincristine|BCNU/CTX/DACT/MP/MTX/PRED/VCR
C10365	Carboplatin_Cyclophosphamide_Mitoxantrone	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Mitoxantrone|CBDCA/CTX/DHAD
C10366	Fluorouracil_Leucovorin-Calcium_Thiotepa	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Thiotepa|CF/5-FU/TSPA
C10367	Interleukin-2_Lymphokine-Activated-Killer-Cells_Monoclonal-Antibody-R24	Chemotherapy_Regimen	Interleukin-2/Lymphokine-Activated Killer Cells/Monoclonal Antibody R24|IL-2/LAK/MOAB R24
C10368	Cyclophosphamide_Etoposide_Thiotepa	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Thiotepa|CTX/TSPA/VP-16
C10369	Dacarbazine_Interleukin-2	Chemotherapy_Regimen	Dacarbazine/Interleukin-2|DTIC/IL-2
C10370	Cisplatin_Dacarbazine_Tamoxifen	Chemotherapy_Regimen	Cisplatin/Dacarbazine/Tamoxifen|CDDP/DTIC/TMX
C10371	Busulfan_Mitoxantrone	Chemotherapy_Regimen	Busulfan/Mitoxantrone|BU/DHAD
C10372	Cyclophosphamide_Interleukin-2_Monoclonal-Antibody-R24	Chemotherapy_Regimen	Cyclophosphamide/Interleukin-2/Monoclonal Antibody R24|CTX/IL-2/MOAB R24
C10373	Chlorambucil_Etoposide_Prednisone_Vincristine	Chemotherapy_Regimen	Chlorambucil/Etoposide/Prednisone/Vincristine|CLB/PRED/VCR/VP-16
C10374	Cytarabine_Etoposide_Prednisone	Chemotherapy_Regimen	Cytarabine/Etoposide/Prednisone|ARA-C/PRED/VP-16
C10375	Busulfan_Cytarabine_Etoposide	Chemotherapy_Regimen	Busulfan/Cytarabine/Etoposide|ARA-C/BU/VP-16
C10376	Doxorubicin_Prochlorperazine	Chemotherapy_Regimen	Doxorubicin/Prochlorperazine|DOX/PCPZ
C10377	Cytarabine_Fludarabine	Chemotherapy_Regimen	Cytarabine/Fludarabine|ARA-C/FAMP
C10378	Doxorubicin_Sargramostim	Chemotherapy_Regimen	Doxorubicin/Sargramostim|DOX/GM-CSF
C10379	Carboplatin_Cisplatin_Ifosfamide	Chemotherapy_Regimen	Carboplatin/Cisplatin/Ifosfamide|CBDCA/CDDP/IFF
C10380	Carboplatin_Doxorubicin_Etoposide_Vincristine	Chemotherapy_Regimen	Carboplatin/Doxorubicin/Etoposide/Vincristine|CBDCA/DOX/VCR/VP-16
C10381	Mechlorethamine_Vincristine	Chemotherapy_Regimen	Mechlorethamine/Vincristine|NM/VCR
C10382	Carboplatin_Etoposide_Mechlorethamine_Vincristine	Chemotherapy_Regimen	Carboplatin/Etoposide/Mechlorethamine/Vincristine|CBDCA/NM/VCR/VP-16
C10383	Cisplatin_Ifosfamide_Sargramostim_Vinblastine	Chemotherapy_Regimen	Cisplatin/Ifosfamide/Sargramostim/Vinblastine|CDDP/GM-CSF/IFF/VBL
C10384	Cisplatin_Etoposide_Ifosfamide_Sargramostim	Chemotherapy_Regimen	Cisplatin/Etoposide/Ifosfamide/Sargramostim|CDDP/GM-CSF/IFF/VP-16
C10385	Cytarabine_Daunorubicin_Sargramostim	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Sargramostim|ARA-C/DNR/GM-CSF
C10386	Ethacrynic-Acid_Melphalan	Chemotherapy_Regimen	Ethacrynic Acid/Melphalan|EA/L-PAM
C10387	Cyclophosphamide_Diethylstilbestrol_Fluorouracil	Chemotherapy_Regimen	Cyclophosphamide/Diethylstilbestrol/Fluorouracil|CTX/DES/5-FU
C10388	BCG_Mitomycin	Chemotherapy_Regimen	BCG/Mitomycin|BCG/MITO
C10389	Carboplatin_Etoposide_Interleukin-1-Beta	Chemotherapy_Regimen	Carboplatin/Etoposide/Interleukin-1-Beta|CBDCA/IL-1B/VP-16
C10390	Dipyridamole_Fluorouracil_Leucovorin-Calcium_Zidovudine	Chemotherapy_Regimen	Dipyridamole/Fluorouracil/Leucovorin Calcium/Zidovudine|CF/DP/5-FU/ZDV
C10391	Cyclophosphamide_Doxorubicin_Etoposide_Methotrexate_Sargramostim_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Methotrexate/Sargramostim/Vincristine|CTX/DOX/GM-CSF/MTX/VCR/VP-16
C10392	Cyclophosphamide_Doxorubicin_Etoposide_Methotrexate_Pentamidine_Sargramostim_Vincristine_Zidovudine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Methotrexate/Pentamidine/Sargramostim/Vincristine/Zidovudine|CTX/DOX/GM-CSF/MTX/PAD/VCR/VP-16/ZDV
C10393	Eflornithine_Lomustine_Procarbazine_Vincristine	Chemotherapy_Regimen	Eflornithine/Lomustine/Procarbazine/Vincristine|CCNU/DFMO/PCB/VCR
C10394	Carboplatin_Doxorubicin	Chemotherapy_Regimen	Carboplatin/Doxorubicin|CBDCA/DOX
C10395	Carboplatin_Doxorubicin_Sargramostim	Chemotherapy_Regimen	Carboplatin/Doxorubicin/Sargramostim|CBDCA/DOX/GM-CSF
C10396	Cisplatin_Lomustine_Vincristine	Chemotherapy_Regimen	Cisplatin/Lomustine/Vincristine|CCNU/CDDP/VCR
C10397	Daunorubicin_Dexamethasone_Vincristine	Chemotherapy_Regimen	Daunorubicin/Dexamethasone/Vincristine|DM/DNR/VCR
C10398	Cyclophosphamide_Etoposide_Mercaptopurine_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Mercaptopurine/Methotrexate|CTX/MP/MTX/VP-16
C10399	Asparaginase_Dexamethasone_Vincristine	Chemotherapy_Regimen	Asparaginase/Dexamethasone/Vincristine|ASP/DM/VCR
C10400	Cyclophosphamide_Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Mercaptopurine/Methotrexate/Vincristine|CTX/MP/MTX/VCR
C10401	Flutamide_Leuprolide	Chemotherapy_Regimen	Flutamide/Leuprolide|FLUT/LEUP
C10402	Cisplatin_Etoposide_Hydrazine-Sulfate	Chemotherapy_Regimen	Cisplatin/Etoposide/Hydrazine Sulfate|CDDP/HDZ/VP-16
C10403	Fluorouracil_L-Leucovorin	Chemotherapy_Regimen	Fluorouracil/L-Leucovorin|5-FU/L-CF
C10404	Carboplatin_Cytarabine_Etoposide_Methylprednisolone	Chemotherapy_Regimen	Carboplatin/Cytarabine/Etoposide/Methylprednisolone|ARA-C/CBDCA/MePRDL/VP-16
C10405	Carboplatin_Mitoxantrone	Chemotherapy_Regimen	Carboplatin/Mitoxantrone|CBDCA/DHAD
C10406	Carboplatin_Etoposide_Melphalan	Chemotherapy_Regimen	Carboplatin/Etoposide/Melphalan|CBDCA/L-PAM/VP-16
C10407	Carmustine_Vincristine	Chemotherapy_Regimen	Carmustine/Vincristine|BCNU/VCR
C10408	Carmustine_Nimodipine_Vincristine	Chemotherapy_Regimen	Carmustine/Nimodipine/Vincristine|BCNU/NIMO/VCR
C10409	Floxuridine_Fluorouracil	Chemotherapy_Regimen	Floxuridine/Fluorouracil|5-FU/FUDR
C10410	Cisplatin_Cyclophosphamide_Interleukin-2	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Interleukin-2|CDDP/CTX/IL-2
C10411	Cisplatin_Cytarabine_Fluorouracil	Chemotherapy_Regimen	Cisplatin/Cytarabine/Fluorouracil|ARA-C/CDDP/5-FU
C10412	Cisplatin_Cytarabine_Fluorouracil_Sargramostim	Chemotherapy_Regimen	Cisplatin/Cytarabine/Fluorouracil/Sargramostim|ARA-C/CDDP/5-FU/GM-CSF
C10413	Asparaginase_Cyclophosphamide_Cytarabine_Methotrexate	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Methotrexate|ARA-C/ASP/CTX/MTX
C10414	Dactinomycin_Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Dactinomycin/Doxorubicin/Mercaptopurine/Methotrexate/Prednisone/Vincristine|DACT/DOX/MP/MTX/PRED/VCR
C10415	Nimodipine_Vincristine	Chemotherapy_Regimen	Nimodipine/Vincristine|NIMO/VCR
C10416	Cytarabine_Methylprednisolone_Mitoxantrone_Vincristine	Chemotherapy_Regimen	Cytarabine/Methylprednisolone/Mitoxantrone/Vincristine|ARA-C/DHAD/MePRDL/VCR
C10417	Carboplatin_Cytarabine_Etoposide	Chemotherapy_Regimen	Carboplatin/Cytarabine/Etoposide|ARA-C/CBDCA/VP-16
C10418	Fluorouracil_Hydroxyurea_Idoxuridine	Chemotherapy_Regimen	Fluorouracil/Hydroxyurea/Idoxuridine|5-FU/HU/IUDR
C10419	Carboplatin_Cisplatin_Doxorubicin_Methotrexate_Vinblastine	Chemotherapy_Regimen	Carboplatin/Cisplatin/Doxorubicin/Methotrexate/Vinblastine|CBDCA/CDDP/DOX/MTX/VBL
C10420	Cisplatin_Cyclosporine	Chemotherapy_Regimen	Cisplatin/Cyclosporine|CDDP/CYSP
C10421	Acivicin_Aminosyn	Chemotherapy_Regimen	Acivicin/Aminosyn|Aminosyn/AT-125
C10422	Carboplatin_Doxorubicin_Methotrexate_Vinblastine	Chemotherapy_Regimen	Carboplatin/Doxorubicin/Methotrexate/Vinblastine|CBDCA/DOX/MTX/VBL
C10423	Carmustine_Etoposide_Thiotepa	Chemotherapy_Regimen	Carmustine/Etoposide/Thiotepa|BCNU/TSPA/VP-16
C10424	Etoposide_Idarubicin_Methotrexate	Chemotherapy_Regimen	Etoposide/Idarubicin/Methotrexate|IDA/MTX/VP-16
C10425	Cisplatin_Etoposide_Thiotepa	Chemotherapy_Regimen	Cisplatin/Etoposide/Thiotepa|CDDP/TSPA/VP-16
C10426	Cisplatin_Doxorubicin_Etoposide_Sargramostim	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Etoposide/Sargramostim|CDDP/DOX/GM-CSF/VP-16
C10427	Cisplatin_Etoposide_Megestrol	Chemotherapy_Regimen	Cisplatin/Etoposide/Megestrol|CDDP/MEG/VP-16
C10428	BCG_Interleukin-2	Chemotherapy_Regimen	BCG/Interleukin-2|BCG/IL-2
C10429	Cisplatin_Cyclophosphamide_Doxorubicin_Prednisone	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Prednisone|CDDP/CTX/DOX/PRED
C10430	Cisplatin_Dihydro-5-Azacytidine	Chemotherapy_Regimen	Cisplatin/Dihydro-5-Azacytidine|CDDP/DHAC
C10431	Interleukin-2_Monoclonal-Antibody-14G2A	Chemotherapy_Regimen	Interleukin-2/Monoclonal Antibody 14G2A|IL-2/MOAB 14G2A
C10432	Carboplatin_Cyclophosphamide_Etanidazole	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Etanidazole|CBDCA/CTX/SR-2508
C10433	Cyclosporine_Interferon-Gamma	Chemotherapy_Regimen	Cyclosporine/Interferon Gamma|CYSP/IFN-G
C10434	Floxuridine_Fluorouracil_Leucovorin-Calcium_Levamisole	Chemotherapy_Regimen	Floxuridine/Fluorouracil/Leucovorin Calcium/Levamisole|CF/5-FU/FUDR/LEV
C10435	Cimetidine_Cyclophosphamide_Indomethacin_Interleukin-2	Chemotherapy_Regimen	Cimetidine/Cyclophosphamide/Indomethacin/Interleukin-2|cimetidine/CTX/IL-2/Indomethacin
C10436	Amifostine_Carboplatin_Cisplatin	Chemotherapy_Regimen	Amifostine/Carboplatin/Cisplatin|CBDCA/CDDP/WR-2721
C10437	Dipyridamole_Fluorouracil_PALA	Chemotherapy_Regimen	Dipyridamole/Fluorouracil/PALA|DP/5-FU/PALA
C10438	Daunorubicin_Tamoxifen	Chemotherapy_Regimen	Daunorubicin/Tamoxifen|DNR/TMX
C10439	Cisplatin_Cytarabine_Dexamethasone_Etoposide_Sargramostim	Chemotherapy_Regimen	Cisplatin/Cytarabine/Dexamethasone/Etoposide/Sargramostim|ARA-C/CDDP/DM/GM-CSF/VP-16
C10440	Dexamethasone_Doxorubicin_Quinine_Verapamil_Vincristine	Chemotherapy_Regimen	Dexamethasone/Doxorubicin/Quinine/Verapamil/Vincristine|DM/DOX/QUIN/VCR/VPAM
C10441	Carboplatin_Etoposide_Monoclonal-Antibody-3F8	Chemotherapy_Regimen	Carboplatin/Etoposide/Monoclonal Antibody 3F8|CBDCA/MOAB 3F8/VP-16
C10442	Cyclophosphamide_Doxorubicin_Etoposide_Prednisolone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Prednisolone/Vincristine|CTX/DOX/PRDL/VCR/VP-16
C10443	Cyclophosphamide_Dexverapamil_Doxorubicin_Etoposide_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dexverapamil/Doxorubicin/Etoposide/Prednisone/Vincristine|CTX/DOX/PRED/R-VPAM/VCR/VP-16
C10444	Cyclophosphamide_Dexverapamil_Doxorubicin_Etoposide_Prednisolone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dexverapamil/Doxorubicin/Etoposide/Prednisolone/Vincristine|CTX/DOX/PRDL/R-VPAM/VCR/VP-16
C10445	Fluorouracil_Idoxuridine_Leucovorin-Calcium	Chemotherapy_Regimen	Fluorouracil/Idoxuridine/Leucovorin Calcium|CF/5-FU/IUDR
C10446	Filgrastim_Paclitaxel	Chemotherapy_Regimen	Filgrastim/Paclitaxel|G-CSF/TAX
C10447	Amifostine_Mitomycin	Chemotherapy_Regimen	Amifostine/Mitomycin|MITO/WR-2721
C10448	Cytarabine_Interleukin-3	Chemotherapy_Regimen	Cytarabine/Interleukin-3|ARA-C/IL-3
C10449	Carboplatin_Cisplatin_Etoposide_Sargramostim	Chemotherapy_Regimen	Carboplatin/Cisplatin/Etoposide/Sargramostim|CBDCA/CDDP/GM-CSF/VP-16
C10450	Chlorambucil_Epirubicin	Chemotherapy_Regimen	Chlorambucil/Epirubicin|CLB/EPI
C10451	Altretamine_Carboplatin_Cyclophosphamide	Chemotherapy_Regimen	Altretamine/Carboplatin/Cyclophosphamide|CBDCA/CTX/HMM
C10452	Cyclophosphamide_Doxorubicin_Fluorouracil_Methotrexate_Prednisone	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Methotrexate/Prednisone|CTX/DOX/5-FU/MTX/PRED
C10453	Cisplatin_Cyclophosphamide_Fluorouracil_Methotrexate_Prednisone	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Fluorouracil/Methotrexate/Prednisone|CDDP/CTX/5-FU/MTX/PRED
C10454	Cyclophosphamide_Melphalan	Chemotherapy_Regimen	Cyclophosphamide/Melphalan|CTX/L-PAM
C10455	Bleomycin_Cisplatin_Etoposide_Ifosfamide	Chemotherapy_Regimen	Bleomycin/Cisplatin/Etoposide/Ifosfamide|BLEO/CDDP/IFF/VP-16
C10456	Cisplatin_Doxorubicin_Filgrastim_Methotrexate_Vinblastine	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Filgrastim/Methotrexate/Vinblastine|CDDP/DOX/G-CSF/MTX/VBL
C10457	Cisplatin_Filgrastim_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Filgrastim/Paclitaxel|CDDP/G-CSF/TAX
C10458	Flutamide_Leuprolide_Suramin	Chemotherapy_Regimen	Flutamide/Leuprolide/Suramin|FLUT/LEUP/SUR
C10459	Fluorouracil_Leucovorin-Calcium_Mitoxantrone_Vincristine	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Mitoxantrone/Vincristine|CF/DHAD/5-FU/VCR
C10460	Cytarabine_Daunorubicin_Pegaspargase_Prednisone_Vincristine	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Pegaspargase/Prednisone/Vincristine|ARA-C/DNR/PEG-ASP/PRED/VCR
C10461	Fluorouracil_Interleukin-2_Leucovorin-Calcium_Lymphokine-Activated-Killer-Cells	Chemotherapy_Regimen	Fluorouracil/Interleukin-2/Leucovorin Calcium/Lymphokine-Activated Killer Cells|CF/5-FU/IL-2/LAK
C10462	Carboplatin_Interleukin-1-Alpha	Chemotherapy_Regimen	Carboplatin/Interleukin-1-Alpha|CBDCA/IL-1A
C10463	Carboplatin_Etoposide_Ifosfamide_Sargramostim	Chemotherapy_Regimen	Carboplatin/Etoposide/Ifosfamide/Sargramostim|CBDCA/GM-CSF/IFF/VP-16
C10464	Cisplatin_Cyclophosphamide_Leuprolide	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Leuprolide|CDDP/CTX/LEUP
C10465	Interferon-Gamma_Interleukin-2_Tumor-Infiltrating-Lymphocytes	Chemotherapy_Regimen	Interferon Gamma/Interleukin-2/Tumor Infiltrating Lymphocytes|IFN-G/IL-2/TIL
C10466	Asparaginase_Cytarabine_Methotrexate_Prednisone_Thioguanine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Methotrexate/Prednisone/Thioguanine|ARA-C/ASP/MTX/PRED/TG
C10467	Asparaginase_Cytarabine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Methotrexate/Prednisone/Vincristine|ARA-C/ASP/MTX/PRED/VCR
C10468	Asparaginase_Prednisone	Chemotherapy_Regimen	Asparaginase/Prednisone|ASP/PRED
C10469	Cyclophosphamide_Cytarabine_Daunorubicin_Methotrexate_Prednisone_Thioguanine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Daunorubicin/Methotrexate/Prednisone/Thioguanine/Vincristine|ARA-C/CTX/DNR/MTX/PRED/TG/VCR
C10470	Asparaginase_Cyclophosphamide_Cytarabine_Daunorubicin_Methotrexate_Prednisone_Thioguanine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Daunorubicin/Methotrexate/Prednisone/Thioguanine/Vincristine|ARA-C/ASP/CTX/DNR/MTX/PRED/TG/VCR
C10471	Doxorubicin_Estradiol_Goserelin_Thiotepa_Vinblastine	Chemotherapy_Regimen	Doxorubicin/Estradiol/Goserelin/Thiotepa/Vinblastine|DOX/ESDL/TSPA/VBL/ZDX
C10472	Fluoxymesterone_Tamoxifen	Chemotherapy_Regimen	Fluoxymesterone/Tamoxifen|FXM/TMX
C10473	Carboplatin_Fluorouracil_Procarbazine	Chemotherapy_Regimen	Carboplatin/Fluorouracil/Procarbazine|CBDCA/5-FU/PCB
C10474	Fluorouracil_Leucovorin-Calcium_Zidovudine	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Zidovudine|CF/5-FU/ZDV
C10475	Filgrastim_Piroxantrone	Chemotherapy_Regimen	Filgrastim/Piroxantrone|G-CSF/PXT
C10476	Doxorubicin_Paclitaxel	Chemotherapy_Regimen	Doxorubicin/Paclitaxel|DOX/TAX|Paclitaxel/Doxorubicin
C10477	Doxorubicin_Filgrastim_Paclitaxel	Chemotherapy_Regimen	Doxorubicin/Filgrastim/Paclitaxel|DOX/G-CSF/TAX
C10478	Cyclophosphamide_Daunorubicin_Dexamethasone_Etoposide_Methotrexate_Thiotepa_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Daunorubicin/Dexamethasone/Etoposide/Methotrexate/Thiotepa/Vincristine|CTX/DM/DNR/MTX/TSPA/VCR/VP-16
C10479	Asparaginase_Cytarabine_Etoposide_Methotrexate_Methylprednisolone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Etoposide/Methotrexate/Methylprednisolone/Vincristine|ARA-C/ASP/MePRDL/MTX/VCR/VP-16
C10480	Asparaginase_Cytarabine_Etoposide	Chemotherapy_Regimen	Asparaginase/Cytarabine/Etoposide|ARA-C/ASP/VP-16
C10481	Interleukin-2_PEG-Interleukin-2	Chemotherapy_Regimen	Interleukin-2/PEG-Interleukin-2|IL-2/PEG-IL-2
C10482	Cisplatin_Dacarbazine_Interleukin-2_Tamoxifen	Chemotherapy_Regimen	Cisplatin/Dacarbazine/Interleukin-2/Tamoxifen|CDDP/DTIC/IL-2/TMX
C10483	Idoxuridine_Leucovorin-Calcium	Chemotherapy_Regimen	Idoxuridine/Leucovorin Calcium|CF/IUDR
C10484	Cyclophosphamide_Dexamethasone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Vincristine|CTX/DM/VCR
C10485	Cyclophosphamide_Dexamethasone_Filgrastim_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Filgrastim/Vincristine|CTX/DM/G-CSF/VCR
C10486	Carmustine_Cisplatin_Cyclophosphamide_Filgrastim	Chemotherapy_Regimen	Carmustine/Cisplatin/Cyclophosphamide/Filgrastim|BCNU/CDDP/CTX/G-CSF
C10487	Cyclophosphamide_Doxorubicin_Filgrastim_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Filgrastim/Prednisone/Vincristine|CTX/DOX/G-CSF/PRED/VCR
C10488	Diaziquone_Sargramostim	Chemotherapy_Regimen	Diaziquone/Sargramostim|AZQ/GM-CSF
C10489	Cyclophosphamide_Fludarabine	Chemotherapy_Regimen	Cyclophosphamide/Fludarabine|CTX/FAMP
C10490	Filgrastim_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Filgrastim/Fluorouracil/Leucovorin Calcium|CF/5-FU/G-CSF
C10491	Asparaginase_Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Thioguanine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Thioguanine/Vincristine|ARA-C/ASP/CTX/DM/DOX/TG/VCR
C10492	Carboplatin_Interleukin-3	Chemotherapy_Regimen	Carboplatin/Interleukin-3|CBDCA/IL-3
C10493	Methotrexate_Thioguanine	Chemotherapy_Regimen	Methotrexate/Thioguanine|MTX/TG
C10494	Carboplatin_Fluorouracil_Hydroxyurea_Leucovorin-Calcium	Chemotherapy_Regimen	Carboplatin/Fluorouracil/Hydroxyurea/Leucovorin Calcium|CBDCA/CF/5-FU/HU
C10495	Cisplatin_Fluorouracil_Hydroxyurea_Leucovorin-Calcium	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Hydroxyurea/Leucovorin Calcium|CDDP/CF/5-FU/HU
C10496	Carboplatin_Doxorubicin_Ifosfamide	Chemotherapy_Regimen	Carboplatin/Doxorubicin/Ifosfamide|CBDCA/DOX/IFF
C10497	Cyclophosphamide_Doxorubicin_Filgrastim	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Filgrastim|CTX/DOX/G-CSF
C10498	Doxorubicin_Vinblastine	Chemotherapy_Regimen	Doxorubicin/Vinblastine|DOX/VBL
C10499	Dimethylbusulfan_Etoposide	Chemotherapy_Regimen	Dimethylbusulfan/Etoposide|DMB/VP-16
C10500	Dacarbazine_Tamoxifen	Chemotherapy_Regimen	Dacarbazine/Tamoxifen|DTIC/TMX
C10501	Amifostine_Cisplatin_Etoposide	Chemotherapy_Regimen	Amifostine/Cisplatin/Etoposide|CDDP/VP-16/WR-2721
C10502	Cyclophosphamide_Etoposide_Sargramostim	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Sargramostim|CTX/GM-CSF/VP-16
C10503	Piroxantrone_Sargramostim	Chemotherapy_Regimen	Piroxantrone/Sargramostim|GM-CSF/PXT
C10504	Carboplatin_Epoetin-Alfa_Etoposide	Chemotherapy_Regimen	Carboplatin/Epoetin Alfa/Etoposide|CBDCA/EPO/VP-16
C10505	Carboplatin_Cytarabine_Dexamethasone	Chemotherapy_Regimen	Carboplatin/Cytarabine/Dexamethasone|ARA-C/CBDCA/DM
C10506	Carboplatin_Cytarabine_Dexamethasone_Sargramostim	Chemotherapy_Regimen	Carboplatin/Cytarabine/Dexamethasone/Sargramostim|ARA-C/CBDCA/DM/GM-CSF
C10507	Carboplatin_Dacarbazine	Chemotherapy_Regimen	Carboplatin/Dacarbazine|CBDCA/DTIC
C10508	Carboplatin_Dacarbazine_Tamoxifen	Chemotherapy_Regimen	Carboplatin/Dacarbazine/Tamoxifen|CBDCA/DTIC/TMX
C10509	Cyclophosphamide_Dexamethasone_Doxorubicin_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Doxorubicin/Methotrexate/Vincristine|CTX/DM/DOX/MTX/VCR
C10510	Cyclophosphamide_Filgrastim	Chemotherapy_Regimen	Cyclophosphamide/Filgrastim|CTX/G-CSF
C10511	Filgrastim_Interleukin-1-Beta	Chemotherapy_Regimen	Filgrastim/Interleukin-1-Beta|G-CSF/IL-1B
C10512	Cisplatin_Fluorouracil_Hydroxyurea	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Hydroxyurea|CDDP/5-FU/HU
C10513	Cisplatin_Filgrastim_Fluorouracil_Hydroxyurea	Chemotherapy_Regimen	Cisplatin/Filgrastim/Fluorouracil/Hydroxyurea|CDDP/5-FU/G-CSF/HU
C10514	Etoposide_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Etoposide/Fluorouracil/Leucovorin Calcium|CF/5-FU/VP-16
C10515	Brequinar_Fluorouracil	Chemotherapy_Regimen	Brequinar/Fluorouracil|BREQ/5-FU
C10516	Cyclophosphamide_Interleukin-3_Sargramostim	Chemotherapy_Regimen	Cyclophosphamide/Interleukin-3/Sargramostim|CTX/GM-CSF/IL-3
C10517	Cyclophosphamide_Detox_Interleukin-2	Chemotherapy_Regimen	Cyclophosphamide/Detox/Interleukin-2|CTX/DETOX/IL-2
C10518	Bleomycin_Cisplatin_Etoposide_Filgrastim	Chemotherapy_Regimen	Bleomycin/Cisplatin/Etoposide/Filgrastim|BLEO/CDDP/G-CSF/VP-16
C10519	Bleomycin_Cisplatin_Filgrastim_Vincristine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Filgrastim/Vincristine|BLEO/CDDP/G-CSF/VCR
C10520	Bleomycin_Cisplatin_Etoposide_Filgrastim_Ifosfamide	Chemotherapy_Regimen	Bleomycin/Cisplatin/Etoposide/Filgrastim/Ifosfamide|BLEO/CDDP/G-CSF/IFF/VP-16
C10521	Chlorambucil_Ethacrynic-Acid	Chemotherapy_Regimen	Chlorambucil/Ethacrynic Acid|CLB/EA
C10522	Cyclosporine_Dexamethasone_Doxorubicin_Vincristine	Chemotherapy_Regimen	Cyclosporine/Dexamethasone/Doxorubicin/Vincristine|CYSP/DM/DOX/VCR
C10523	Interferon-Gamma_Macrophage-Colony-Stimulating-Factor	Chemotherapy_Regimen	Interferon Gamma/Macrophage Colony-Stimulating Factor|IFN-G/M-CSF
C10524	Cyclophosphamide_Doxorubicin_Fluorouracil_Interleukin-3_Leucovorin-Calcium	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Interleukin-3/Leucovorin Calcium|CF/CTX/DOX/5-FU/IL-3
C10525	Cyclophosphamide_Doxorubicin_Fluorouracil_Interleukin-3_Leucovorin-Calcium_Sargramostim	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Interleukin-3/Leucovorin Calcium/Sargramostim|CF/CTX/DOX/5-FU/GM-CSF/IL-3|Cyclophosphamide/Doxorubicin/Fluorouracil/Interleukin-3/Leucovorincalcium/Sargramostim
C10526	Doxorubicin_Suramin	Chemotherapy_Regimen	Doxorubicin/Suramin|DOX/SUR
C10527	Pentoxifylline_Suramin_Thiotepa	Chemotherapy_Regimen	Pentoxifylline/Suramin/Thiotepa|PTX/SUR/TSPA
C10528	Cisplatin_Filgrastim_Methotrexate_Vinblastine	Chemotherapy_Regimen	Cisplatin/Filgrastim/Methotrexate/Vinblastine|CDDP/G-CSF/MTX/VBL
C10529	Doxorubicin_Filgrastim_Thiotepa	Chemotherapy_Regimen	Doxorubicin/Filgrastim/Thiotepa|DOX/G-CSF/TSPA
C10530	Doxorubicin_Thiotepa	Chemotherapy_Regimen	Doxorubicin/Thiotepa|DOX/TSPA
C10531	Cisplatin_Fluorouracil_Mitomycin_Vindesine	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Mitomycin/Vindesine|CDDP/DAVA/5-FU/MITO
C10532	Cisplatin_Doxorubicin_Methotrexate_Sargramostim_Vinblastine	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Methotrexate/Sargramostim/Vinblastine|CDDP/DOX/GM-CSF/MTX/VBL
C10533	Melphalan_Vincristine	Chemotherapy_Regimen	Melphalan/Vincristine|L-PAM/VCR
C10534	Carboplatin_Cisplatin_Cyclophosphamide_Filgrastim	Chemotherapy_Regimen	Carboplatin/Cisplatin/Cyclophosphamide/Filgrastim|CBDCA/CDDP/CTX/G-CSF
C10535	Filgrastim_Topotecan	Chemotherapy_Regimen	Filgrastim/Topotecan|G-CSF/TOPO
C10536	Cyclophosphamide_Dexamethasone_Doxorubicin_Quinine_Verapamil_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Doxorubicin/Quinine/Verapamil/Vincristine|CTX/DM/DOX/QUIN/VCR/VPAM
C10537	Carboplatin_Ifosfamide_Sargramostim	Chemotherapy_Regimen	Carboplatin/Ifosfamide/Sargramostim|CBDCA/GM-CSF/IFF
C10538	Epoetin-Alfa_Filgrastim	Chemotherapy_Regimen	Epoetin Alfa/Filgrastim|EPO/G-CSF
C10539	Interleukin-2_Levamisole	Chemotherapy_Regimen	Interleukin-2/Levamisole|IL-2/LEV
C10540	Carboplatin_Etoposide_Ifosfamide_Interleukin-1-Alpha	Chemotherapy_Regimen	Carboplatin/Etoposide/Ifosfamide/Interleukin-1-Alpha|CBDCA/IFF/IL-1A/VP-16
C10541	Cisplatin_Cyclophosphamide_Etoposide_Interleukin-2_Sargramostim	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Etoposide/Interleukin-2/Sargramostim|CDDP/CTX/GM-CSF/IL-2/VP-16
C10542	Etoposide_Metronidazole	Chemotherapy_Regimen	Etoposide/Metronidazole|METRO/VP-16
C10543	Etoposide_Ketoconazole_Metronidazole	Chemotherapy_Regimen	Etoposide/Ketoconazole/Metronidazole|KCZ/METRO/VP-16
C10544	Dipyridamole_Etoposide_Ketoconazole_Metronidazole	Chemotherapy_Regimen	Dipyridamole/Etoposide/Ketoconazole/Metronidazole|DP/KCZ/METRO/VP-16
C10545	Dipyridamole_Etoposide_Ketoconazole_Metronidazole_Tamoxifen	Chemotherapy_Regimen	Dipyridamole/Etoposide/Ketoconazole/Metronidazole/Tamoxifen|DP/KCZ/METRO/TMX/VP-16
C10546	Dipyridamole_Etoposide_Ketoconazole_Metronidazole_Quinidine_Tamoxifen	Chemotherapy_Regimen	Dipyridamole/Etoposide/Ketoconazole/Metronidazole/Quinidine/Tamoxifen|DP/KCZ/METRO/QND/TMX/VP-16
C10547	Cyclosporine_Dipyridamole_Etoposide_Ketoconazole_Metronidazole_Quinidine_Tamoxifen	Chemotherapy_Regimen	Cyclosporine/Dipyridamole/Etoposide/Ketoconazole/Metronidazole/Quinidine/Tamoxifen|CYSP/DP/KCZ/METRO/QND/TMX/VP-16
C10548	Doxorubicin_Verapamil	Chemotherapy_Regimen	Doxorubicin/Verapamil|DOX/VPAM
C10549	Cisplatin_Etoposide_Filgrastim_Melphalan	Chemotherapy_Regimen	Cisplatin/Etoposide/Filgrastim/Melphalan|CDDP/G-CSF/L-PAM/VP-16
C10550	Asparaginase_Cyclophosphamide_Daunorubicin_Filgrastim_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Daunorubicin/Filgrastim/Prednisone/Vincristine|ASP/CTX/DNR/G-CSF/PRED/VCR
C10551	Asparaginase_Cyclophosphamide_Cytarabine_Filgrastim_Mercaptopurine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Filgrastim/Mercaptopurine/Vincristine|ARA-C/ASP/CTX/G-CSF/MP/VCR
C10552	Altretamine_Cisplatin_Etoposide	Chemotherapy_Regimen	Altretamine/Cisplatin/Etoposide|CDDP/HMM/VP-16
C10553	Amifostine_Melphalan	Chemotherapy_Regimen	Amifostine/Melphalan|L-PAM/WR-2721
C10554	Cytarabine_Pegaspargase	Chemotherapy_Regimen	Cytarabine/Pegaspargase|ARA-C/PEG-ASP
C10555	Idarubicin_Tretinoin	Chemotherapy_Regimen	Idarubicin/Tretinoin|ATRA/IDA
C10556	Idarubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Idarubicin/Mercaptopurine/Methotrexate/Prednisone/Vincristine|IDA/MP/MTX/PRED/VCR
C10557	Cyclophosphamide_Doxorubicin_Etoposide_Medroxyprogesterone_Quinine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Medroxyprogesterone/Quinine|CTX/DOX/MPA/QUIN/VP-16
C10558	Pentostatin_Sargramostim	Chemotherapy_Regimen	Pentostatin/Sargramostim|DCF/GM-CSF
C10559	Carboplatin_Diethyldithiocarbamate	Chemotherapy_Regimen	Carboplatin/Diethyldithiocarbamate|CBDCA/DTC
C10560	Levamisole_Tamoxifen	Chemotherapy_Regimen	Levamisole/Tamoxifen|LEV/TMX
C10561	Fluorouracil_Idoxuridine_Leucovorin-Calcium_PALA	Chemotherapy_Regimen	Fluorouracil/Idoxuridine/Leucovorin Calcium/PALA|CF/5-FU/IUDR/PALA
C10562	Fluorouracil_Leucovorin-Calcium_PALA_Zidovudine	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/PALA/Zidovudine|CF/5-FU/PALA/ZDV
C10563	Somatuline_Suramin	Chemotherapy_Regimen	Somatuline/Suramin|Somatuline/SUR|Suramin/Somatuline
C10564	Flutamide_Leuprolide_Somatuline_Suramin	Chemotherapy_Regimen	Flutamide/Leuprolide/Somatuline/Suramin|FLUT/LEUP/somatuline/SUR
C10565	Interleukin-2_Interleukin-6	Chemotherapy_Regimen	Interleukin-2/Interleukin-6|IL-2/IL-6
C10566	Fluorouracil_Leucovorin-Calcium_Trimetrexate-Glucuronate	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Trimetrexate Glucuronate|CF/5-FU/TMTX
C10567	Asparaginase_Cytarabine_Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Mercaptopurine/Methotrexate/Vincristine|ARA-C/ASP/MP/MTX/VCR
C10568	Asparaginase_Mercaptopurine_Methotrexate_Pegaspargase_Vincristine	Chemotherapy_Regimen	Asparaginase/Mercaptopurine/Methotrexate/Pegaspargase/Vincristine|ARA-C/MP/MTX/PEG-ASP/VCR
C10569	Dexamethasone_Doxorubicin_Methotrexate_Pegaspargase_Vincristine	Chemotherapy_Regimen	Dexamethasone/Doxorubicin/Methotrexate/Pegaspargase/Vincristine|DM/DOX/MTX/PEG-ASP/VCR
C10570	Asparaginase_Dexamethasone_Doxorubicin_Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Asparaginase/Dexamethasone/Doxorubicin/Mercaptopurine/Methotrexate/Vincristine|ASP/DM/DOX/MP/MTX/VCR
C10571	Asparaginase_Dexamethasone_Doxorubicin_Methotrexate_Vincristine	Chemotherapy_Regimen	Asparaginase/Dexamethasone/Doxorubicin/Methotrexate/Vincristine|ASP/DM/DOX/MTX/VCR
C10572	Asparaginase_Dexamethasone_Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Asparaginase/Dexamethasone/Mercaptopurine/Methotrexate/Vincristine|ASP/DM/MP/MTX/VCR
C10573	Dexamethasone_Doxorubicin_Mercaptopurine_Methotrexate_Pegaspargase_Vincristine	Chemotherapy_Regimen	Dexamethasone/Doxorubicin/Mercaptopurine/Methotrexate/Pegaspargase/Vincristine|DM/DOX/MP/MTX/PEG-ASP/VCR
C10574	Dexamethasone_Mercaptopurine_Methotrexate_Pegaspargase_Vincristine	Chemotherapy_Regimen	Dexamethasone/Mercaptopurine/Methotrexate/Pegaspargase/Vincristine|DM/MP/MTX/PEG-ASP/VCR
C10575	Dexamethasone_Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Dexamethasone/Mercaptopurine/Methotrexate/Vincristine|DM/MP/MTX/VCR
C10576	Asparaginase_Cyclophosphamide_Cytarabine_Filgrastim	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Filgrastim|ARA-C/ASP/CTX/G-CSF
C10577	Asparaginase_Cyclophosphamide_Filgrastim	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Filgrastim|ARA-C/CTX/G-CSF
C10578	Asparaginase_Filgrastim_Teniposide	Chemotherapy_Regimen	Asparaginase/Filgrastim/Teniposide|ARA-C/G-CSF/VM-26
C10579	Doxorubicin_Filgrastim_Mercaptopurine_Prednisone_Vincristine	Chemotherapy_Regimen	Doxorubicin/Filgrastim/Mercaptopurine/Prednisone/Vincristine|DOX/G-CSF/MP/PRED/VCR
C10580	Doxorubicin_Filgrastim_Prednisone_Vincristine	Chemotherapy_Regimen	Doxorubicin/Filgrastim/Prednisone/Vincristine|DOX/G-CSF/PRED/VCR
C10581	Cyclophosphamide_Dactinomycin_Doxorubicin_Filgrastim_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dactinomycin/Doxorubicin/Filgrastim/Vincristine|CTX/DACT/DOX/G-CSF/VCR
C10582	Etoposide_Filgrastim_Melphalan	Chemotherapy_Regimen	Etoposide/Filgrastim/Melphalan|G-CSF/L-PAM/VP-16
C10583	Cisplatin_Doxorubicin_Etoposide_Filgrastim_Ifosfamide	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Etoposide/Filgrastim/Ifosfamide|CDDP/DOX/G-CSF/IFF/VP-16
C10584	Bleomycin_Doxorubicin_Etoposide_Mechlorethamine_Vinblastine_Vincristine	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Etoposide/Mechlorethamine/Vinblastine/Vincristine|BLEO/DOX/NM/VBL/VCR/VP-16
C10585	Interleukin-1-Alpha_Interleukin-2	Chemotherapy_Regimen	Interleukin-1-Alpha/Interleukin-2|IL-1A/IL-2
C10586	Trifluoperazine_Verapamil	Chemotherapy_Regimen	Trifluoperazine/Verapamil|TFPZ/VPAM
C10587	Doxorubicin_Filgrastim	Chemotherapy_Regimen	Doxorubicin/Filgrastim|DOX/G-CSF
C10588	Doxorubicin_Trifluoperazine_Vinblastine_Verapamil	Chemotherapy_Regimen	Doxorubicin/Trifluoperazine/Vinblastine/Verapamil|DOX/Trifluoperazine/VBL/VPAM
C10589	Carboplatin_Edatrexate	Chemotherapy_Regimen	Carboplatin/Edatrexate|CBDCA/EDAM|Carboplatin/10-EdAM
C10590	BCG_Isoniazid	Chemotherapy_Regimen	BCG/Isoniazid|BCG/INH
C10591	Cisplatin_Edatrexate	Chemotherapy_Regimen	Cisplatin/Edatrexate|CDDP/EDAM|Cisplatin/10-EdAM
C10592	Hexamethylene-Bisacetamide_Tretinoin	Chemotherapy_Regimen	Hexamethylene Bisacetamide/Tretinoin|ATRA/HMBA
C10593	Bromocriptine_Flutamide	Chemotherapy_Regimen	Bromocriptine/Flutamide|BRCR/FLUT
C10594	Bromocriptine_Flutamide_Leuprolide	Chemotherapy_Regimen	Bromocriptine/Flutamide/Leuprolide|BRCR/FLUT/LEUP
C10595	Flutamide_Ketoconazole_Leuprolide	Chemotherapy_Regimen	Flutamide/Ketoconazole/Leuprolide|FLUT/KCZ/LEUP
C10596	Flutamide_Ketoconazole	Chemotherapy_Regimen	Flutamide/Ketoconazole|FLUT/KCZ
C10597	Trifluoperazine_Verapamil_Vinblastine	Chemotherapy_Regimen	Trifluoperazine/Verapamil/Vinblastine|TFPZ/VBL/VPAM
C10598	Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide_Fluorouracil_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Etoposide/Fluorouracil/Vincristine|CDDP/CTX/DOX/5-FU/VCR/VP-16
C10599	Busulfan_Etoposide	Chemotherapy_Regimen	Busulfan/Etoposide|BU/VP-16
C10600	Cytarabine_Etoposide_Methotrexate_Prednisone	Chemotherapy_Regimen	Cytarabine/Etoposide/Methotrexate/Prednisone|ARA-C/MTX/PRED/VP-16
C10601	Cisplatin_Ifosfamide_Mitomycin	Chemotherapy_Regimen	Cisplatin/Ifosfamide/Mitomycin|CDDP/IFF/MITO
C10602	Carboplatin_Etoposide_Interleukin-3	Chemotherapy_Regimen	Carboplatin/Etoposide/Interleukin-3|CBDCA/IL-3/VP-16
C10603	Interleukin-1-Beta_Interleukin-2	Chemotherapy_Regimen	Interleukin-1-Beta/Interleukin-2|IL-1B/IL-2
C10604	Cisplatin_Cyclophosphamide_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Paclitaxel|CDDP/CTX/TAX|Cisplatin/Paclitaxel/Cyclophosphamide
C10605	Indomethacin_Interleukin-1-Alpha_Etoposide	Chemotherapy_Regimen	Indomethacin/Interleukin-1-Alpha/Etoposide|IL-1A/Indomethacin/VP-16
C10606	Amphotericin-B_Colistin-Sulfate_Tobramycin	Chemotherapy_Regimen	Amphotericin B/Colistin Sulfate/Tobramycin|amphotericin B/colistin sulfate/TBM
C10607	Cytarabine_Idarubicin_Interleukin-3	Chemotherapy_Regimen	Cytarabine/Idarubicin/Interleukin-3|ARA-C/IDA/IL-3
C10608	Carboplatin_Cytarabine_Idarubicin	Chemotherapy_Regimen	Carboplatin/Cytarabine/Idarubicin|ARA-C/CBDCA/IDA
C10609	Fluorouracil_Leucovorin-Calcium_Methylmercaptopurine-Riboside_PALA	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Methylmercaptopurine Riboside/PALA|CF/5-FU/MMPR/PALA
C10610	Cisplatin_Muramyl-TriPeptide-Phosphatidylethanolamine-Liposome	Chemotherapy_Regimen	Cisplatin/Muramyl Tripeptide Phosphatidylethanolamine Liposome|CDDP/MTP-PE Liposome
C10611	Ifosfamide_Muramyl-TriPeptide-Phosphatidylethanolamine-Liposome	Chemotherapy_Regimen	Ifosfamide/Muramyl Tripeptide Phosphatidylethanolamine Liposome|IFF/MTP-PE Liposome
C10612	Asparaginase_Daunorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Daunorubicin/Mercaptopurine/Methotrexate/Prednisone/Vincristine|ASP/DNR/MP/MTX/PRED/VCR
C10613	Cyclophosphamide_Cytarabine_Mercaptopurine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Mercaptopurine/Vincristine|ARA-C/CTX/MP/VCR
C10614	Cyclophosphamide_Cytarabine_Doxorubicin_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Doxorubicin/Vincristine|ARA-C/CTX/DOX/VCR
C10615	Etoposide_Ifosfamide_Methotrexate_Vincristine	Chemotherapy_Regimen	Etoposide/Ifosfamide/Methotrexate/Vincristine|IFF/MTX/VCR/VP-16
C10616	Cyclophosphamide_Daunorubicin_Dexamethasone_Methotrexate_Pegaspargase_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Daunorubicin/Dexamethasone/Methotrexate/Pegaspargase/Vincristine|CTX/DM/DNR/MTX/PEG-ASP/VCR
C10617	Dexamethasone_Mercaptopurine_Vincristine	Chemotherapy_Regimen	Dexamethasone/Mercaptopurine/Vincristine|DM/MP/VCR
C10618	Cyclophosphamide_Cytarabine_Pegaspargase	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Pegaspargase|ARA-C/CTX/PEG-ASP
C10619	Cisplatin_Doxorubicin_Edatrexate_Vinblastine	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Edatrexate/Vinblastine|CDDP/DOX/EDAM/VBL
C10620	Cytarabine_Etoposide_Ifosfamide_Mercaptopurine_Methotrexate	Chemotherapy_Regimen	Cytarabine/Etoposide/Ifosfamide/Mercaptopurine/Methotrexate|ARA-C/IFF/MP/MTX/VP-16
C10621	Carboplatin_Cyclophosphamide_Etoposide_Vincristine	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Etoposide/Vincristine|CBDCA/CTX/VCR/VP-16
C10622	Carboplatin_Carmustine_Tamoxifen	Chemotherapy_Regimen	Carboplatin/Carmustine/Tamoxifen|BCNU/CBDCA/TMX
C10623	Cyclophosphamide_Interleukin-1-Alpha	Chemotherapy_Regimen	Cyclophosphamide/Interleukin-1-Alpha|CTX/IL-1A
C10624	Carboplatin_Milodistim	Chemotherapy_Regimen	Carboplatin/Milodistim|CBDCA/PIXY321
C10625	Busulfan_Cyclophosphamide_Cytarabine	Chemotherapy_Regimen	Busulfan/Cyclophosphamide/Cytarabine|ARA-C/BU/CTX
C10626	Cyclosporine_Tamoxifen_Vinblastine	Chemotherapy_Regimen	Cyclosporine/Tamoxifen/Vinblastine|CYSP/TMX/VBL
C10627	Interleukin-2_Interleukin-4_Tumor-Infiltrating-Lymphocytes	Chemotherapy_Regimen	Interleukin-2/Interleukin-4/Tumor Infiltrating Lymphocytes|IL-2/IL-4/TIL
C10628	Cytarabine_Tretinoin	Chemotherapy_Regimen	Cytarabine/Tretinoin|ARA-C/ATRA
C10629	Edatrexate_Ifosfamide	Chemotherapy_Regimen	Edatrexate/Ifosfamide|EDAM/IFF
C10630	Cisplatin_Etoposide_Tretinoin	Chemotherapy_Regimen	Cisplatin/Etoposide/Tretinoin|ATRA/CDDP/VP-16
C10631	Asparaginase_Cisplatin_Cytarabine_Dexamethasone_Etoposide	Chemotherapy_Regimen	Asparaginase/Cisplatin/Cytarabine/Dexamethasone/Etoposide|ARA-C/ASP/CDDP/DM/VP-16
C10632	Cytarabine_Filgrastim_Tretinoin	Chemotherapy_Regimen	Cytarabine/Filgrastim/Tretinoin|ARA-C/ATRA/G-CSF
C10633	Carboplatin_Cyclophosphamide_Etoposide_Melphalan	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Etoposide/Melphalan|CBDCA/CTX/L-PAM/VP-16
C10634	Cyclophosphamide_Doxorubicin_Interleukin-3_Prednisone_Vincristine_Zidovudine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Interleukin-3/Prednisone/Vincristine/Zidovudine|CTX/DOX/IL-3/PRED/VCR/ZDV
C10635	Dexrazoxane_Doxorubicin	Chemotherapy_Regimen	Dexrazoxane/Doxorubicin|ADR-529/DOX
C10636	Doxorubicin_Vinorelbine	Chemotherapy_Regimen	Doxorubicin/Vinorelbine|DOX/VNB
C10637	Fluorouracil_Vinorelbine	Chemotherapy_Regimen	Fluorouracil/Vinorelbine|5-FU/VNB
C10638	Carboplatin_Etoposide_Ifosfamide_Etanidazole	Chemotherapy_Regimen	Carboplatin/Etoposide/Ifosfamide/Etanidazole|CBDCA/IFF/SR-2508/VP-16
C10639	Bleomycin_Doxorubicin_Etoposide_Vincristine	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Etoposide/Vincristine|BLEO/DOX/VCR/VP-16
C10640	Etoposide_Procarbazine_Vincristine	Chemotherapy_Regimen	Etoposide/Procarbazine/Vincristine|PCB/VCR/VP-16
C10641	Doxorubicin_Streptozocin	Chemotherapy_Regimen	Doxorubicin/Streptozocin|DOX/SZC
C10642	Leucovorin-Calcium_Mercaptopurine_Methotrexate	Chemotherapy_Regimen	Leucovorin Calcium/Mercaptopurine/Methotrexate|CF/MP/MTX
C10643	Asparaginase_Mercaptopurine_Methotrexate	Chemotherapy_Regimen	Asparaginase/Mercaptopurine/Methotrexate|ASP/MP/MTX
C10644	Fluorouracil_Leucovorin-Calcium_Mitomycin	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Mitomycin|CF/5-FU/MITO
C10645	Carboplatin_Thymidine	Chemotherapy_Regimen	Carboplatin/Thymidine|CBDCA/TDR
C10646	Etoposide_Topotecan	Chemotherapy_Regimen	Etoposide/Topotecan|TOPO/VP-16
C10647	Dexamethasone_Floxuridine_Leucovorin-Calcium	Chemotherapy_Regimen	Dexamethasone/Floxuridine/Leucovorin Calcium|CF/DM/FUDR
C10648	Amifostine_Cyclophosphamide	Chemotherapy_Regimen	Amifostine/Cyclophosphamide|CTX/WR-2721
C10649	Cyclosporine_Etoposide_Mitoxantrone	Chemotherapy_Regimen	Cyclosporine/Etoposide/Mitoxantrone|CYSP/DHAD/VP-16
C10650	Cyclophosphamide_Didanosine_Doxorubicin_Etoposide_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Didanosine/Doxorubicin/Etoposide/Vincristine|CTX/ddI/DOX/VCR/VP-16
C10651	Cyclosporine_Cytarabine_Daunorubicin	Chemotherapy_Regimen	Cyclosporine/Cytarabine/Daunorubicin|ARA-C/CYSP/DNR
C10652	Cisplatin_Cytarabine_Hydroxyurea	Chemotherapy_Regimen	Cisplatin/Cytarabine/Hydroxyurea|ARA-C/CDDP/HU
C10653	Cisplatin_Topotecan	Chemotherapy_Regimen	Cisplatin/Topotecan|CDDP/TOPO
C10654	Cyclophosphamide_Doxorubicin_Etoposide_Vincristine_Zidovudine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Vincristine/Zidovudine|CTX/DOX/VCR/VP-16/ZDV
C10655	Cyclophosphamide_Paclitaxel	Chemotherapy_Regimen	Cyclophosphamide/Paclitaxel|CTX/TAX|Paclitaxel/Cyclophosphamide
C10656	Estramustine_Vinblastine	Chemotherapy_Regimen	Estramustine/Vinblastine|EM/VBL
C10657	Cytarabine_Dexamethasone_Etoposide_Ifosfamide_Methotrexate_Vincristine	Chemotherapy_Regimen	Cytarabine/Dexamethasone/Etoposide/Ifosfamide/Methotrexate/Vincristine|ARA-C/DM/IFF/MTX/VCR/VP-16
C10658	Bleomycin_Didanosine_Doxorubicin_Vincristine	Chemotherapy_Regimen	Bleomycin/Didanosine/Doxorubicin/Vincristine|BLEO/ddI/DOX/VCR
C10659	Cyclosporine_Dactinomycin_Vincristine	Chemotherapy_Regimen	Cyclosporine/Dactinomycin/Vincristine|CYSP/DACT/VCR
C10660	Busulfan_Cyclophosphamide_Diaziquone	Chemotherapy_Regimen	Busulfan/Cyclophosphamide/Diaziquone|AZQ/BU/CTX
C10661	Carboplatin_Cyclophosphamide_Interleukin-1-Beta	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Interleukin-1-Beta|CBDCA/CTX/IL-1B
C10662	Carboplatin_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Paclitaxel|CBDCA/Paclitaxel|CBDCA/TAX
C10663	Doxorubicin_Fluorouracil_Vinorelbine	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Vinorelbine|DOX/5-FU/VNB
C10664	Etoposide_Paclitaxel	Chemotherapy_Regimen	Etoposide/Paclitaxel|TAX/VP-16
C10665	Doxorubicin_Fluorouracil_Leucovorin-Calcium_Vinorelbine	Chemotherapy_Regimen	Doxorubicin/Fluorouracil/Leucovorin Calcium/Vinorelbine|CF/DOX/5-FU/VNB
C10666	Interferon-Gamma_Melphalan_Tumor-Necrosis-Factor	Chemotherapy_Regimen	Interferon Gamma/Melphalan/Tumor Necrosis Factor|IFN-G/L-PAM/TNF
C10667	Altretamine_Paclitaxel	Chemotherapy_Regimen	Altretamine/Paclitaxel|HMM/TAX
C10668	Carboplatin_Cisplatin_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Cisplatin/Paclitaxel|CBDCA/CDDP/TAX
C10669	Paclitaxel_Topotecan	Chemotherapy_Regimen	Paclitaxel/Topotecan|TAX/TOPO
C10670	Eflornithine_Piroxicam	Chemotherapy_Regimen	Eflornithine/Piroxicam|DFMO/PXM
C10671	Chlorambucil_Cladribine	Chemotherapy_Regimen	Chlorambucil/Cladribine|2-CdA/CLB
C10672	Hydrocortisone_Mitoxantrone	Chemotherapy_Regimen	Hydrocortisone/Mitoxantrone|DHAD/HC
C10673	Cytarabine_Daunorubicin_Etoposide_Interleukin-3	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Etoposide/Interleukin-3|ARA-C/DNR/IL-3/VP-16
C10674	Cytarabine_Dexverapamil_Etoposide_Idarubicin	Chemotherapy_Regimen	Cytarabine/Dexverapamil/Etoposide/Idarubicin|ARA-C/IDA/R-VPAM/VP-16
C10675	Doxorubicin_Melphalan_Methylprednisolone	Chemotherapy_Regimen	Doxorubicin/Melphalan/Methylprednisolone|DOX/L-PAM/MePRDL
C10676	Melphalan_Methylprednisolone	Chemotherapy_Regimen	Melphalan/Methylprednisolone|L-PAM/MePRDL
C10677	Cytarabine_Mercaptopurine	Chemotherapy_Regimen	Cytarabine/Mercaptopurine|ARA-C/MP
C10678	Cyclosporine_Vinblastine	Chemotherapy_Regimen	Cyclosporine/Vinblastine|CYSP/VBL
C10679	Tamoxifen_Vinblastine	Chemotherapy_Regimen	Tamoxifen/Vinblastine|TMX/VBL
C10680	Asparaginase_Cyclophosphamide_Cytarabine_Daunorubicin_Doxorubicin_Mercaptopurine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Daunorubicin/Doxorubicin/Mercaptopurine/Vincristine|ARA-C/ASP/CTX/DNR/DOX/MP/VCR
C10681	Asparaginase_Cyclophosphamide_Cytarabine_Daunorubicin_Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Daunorubicin/Mercaptopurine/Methotrexate/Vincristine|ARA-C/ASP/CTX/DNR/MP/MTX/VCR
C10682	Asparaginase_Daunorubicin_Dexamethasone_Ifosfamide_Mercaptopurine_Methotrexate_Vindesine	Chemotherapy_Regimen	Asparaginase/Daunorubicin/Dexamethasone/Ifosfamide/Mercaptopurine/Methotrexate/Vindesine|ASP/DAVA/DM/DNR/IFF/MP/MTX
C10683	Asparaginase_Cytarabine_Dexamethasone_Etoposide	Chemotherapy_Regimen	Asparaginase/Cytarabine/Dexamethasone/Etoposide|ARA-C/ASP/DM/VP-16
C10684	Dactinomycin_Doxorubicin_Etoposide_Ifosfamide_Vincristine	Chemotherapy_Regimen	Dactinomycin/Doxorubicin/Etoposide/Ifosfamide/Vincristine|DACT/DOX/IFF/VCR/VP-16
C10685	Cytarabine_Idarubicin_Teniposide	Chemotherapy_Regimen	Cytarabine/Idarubicin/Teniposide|ARA-C/IDA/VM-26
C10686	Cyclosporine_Paclitaxel	Chemotherapy_Regimen	Cyclosporine/Paclitaxel|CYSP/TAX
C10687	Dexverapamil_Paclitaxel	Chemotherapy_Regimen	Dexverapamil/Paclitaxel|R-VPAM/TAX
C10688	Ifosfamide_Paclitaxel	Chemotherapy_Regimen	Ifosfamide/Paclitaxel|IFF/TAX
C10689	Etoposide_Tretinoin	Chemotherapy_Regimen	Etoposide/Tretinoin|ATRA/VP-16
C10690	Aminoglutethimide_Suramin	Chemotherapy_Regimen	Aminoglutethimide/Suramin|AGT/SUR
C10691	PSC-833_Vinblastine	Chemotherapy_Regimen	PSC 833/Vinblastine|PSC 833/VBL|PSC/Vinblastine
C10692	Cytarabine_Fludarabine_Idarubicin	Chemotherapy_Regimen	Cytarabine/Fludarabine/Idarubicin|ARA-C/FAMP/IDA
C10693	Cisplatin_Fluorouracil_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Paclitaxel|CDDP/5-FU/TAX
C10694	Cisplatin_Estramustine_Etoposide	Chemotherapy_Regimen	Cisplatin/Estramustine/Etoposide|CDDP/EM/VP-16
C10695	Cisplatin_Decitabine	Chemotherapy_Regimen	Cisplatin/Decitabine|CDDP/DAC
C10696	Cisplatin_Doxorubicin_Etoposide_Vincristine	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Etoposide/Vincristine|CDDP/DOX/VCR/VP-16
C10697	Carboplatin_Estramustine_Etoposide	Chemotherapy_Regimen	Carboplatin/Estramustine/Etoposide|CBDCA/EM/VP-16
C10698	Cyclophosphamide_Epirubicin	Chemotherapy_Regimen	Cyclophosphamide/Epirubicin|CTX/EPI
C10699	Epoetin-Alfa_Interleukin-3	Chemotherapy_Regimen	Epoetin Alfa/Interleukin-3|EPO/IL-3
C10700	Interleukin-2_Macrophage-Colony-Stimulating-Factor	Chemotherapy_Regimen	Interleukin-2/Macrophage Colony-Stimulating Factor|IL-2/M-CSF
C10701	Bicalutamide_Leuprolide	Chemotherapy_Regimen	Bicalutamide/Leuprolide|CDX/LEUP
C10702	Bicalutamide_Goserelin	Chemotherapy_Regimen	Bicalutamide/Goserelin|CDX/ZDX
C10703	Fluorouracil_Triacetyluridine	Chemotherapy_Regimen	Fluorouracil/Triacetyluridine|5-FU/TAU
C10704	Cisplatin_Floxuridine_Leucovorin-Calcium	Chemotherapy_Regimen	Cisplatin/Floxuridine/Leucovorin Calcium|CDDP/CF/FUDR
C10705	Carmustine_Cisplatin_Thiotepa	Chemotherapy_Regimen	Carmustine/Cisplatin/Thiotepa|BCNU/CDDP/TSPA
C10706	Carboplatin_Cisplatin_Cyclophosphamide_Etoposide	Chemotherapy_Regimen	Carboplatin/Cisplatin/Cyclophosphamide/Etoposide|CBDCA/CDDP/CTX/VP-16
C10707	Leuprolide_Suramin	Chemotherapy_Regimen	Leuprolide/Suramin|LEUP/SUR
C10708	Aminoglutethimide_Leuprolide	Chemotherapy_Regimen	Aminoglutethimide/Leuprolide|AGT/LEUP
C10709	Ketoconazole_Paclitaxel	Chemotherapy_Regimen	Ketoconazole/Paclitaxel|KCZ/TAX
C10710	Carboplatin_Interleukin-1-Alpha_Methylene-Blue	Chemotherapy_Regimen	Carboplatin/Interleukin-1-Alpha/Methylene Blue|CBDCA/IL-1A/MB
C10711	Asparaginase_Cytarabine_Dexamethasone_Doxorubicin_Mercaptopurine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Dexamethasone/Doxorubicin/Mercaptopurine/Vincristine|ARA-C/ASP/DM/DOX/MP/VCR
C10712	Asparaginase_Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Mercaptopurine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Mercaptopurine/Vincristine|ARA-C/ASP/CTX/DM/DOX/MP/VCR
C10713	Asparaginase_Cyclophosphamide_Cytarabine_Dexamethasone_Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Dexamethasone/Mercaptopurine/Methotrexate/Vincristine|ARA-C/ASP/CTX/DM/MP/MTX/VCR
C10714	Cyclosporine_Interleukin-2_Methylprednisolone	Chemotherapy_Regimen	Cyclosporine/Interleukin-2/Methylprednisolone|CYSP/IL-2/MePRDL
C10715	Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Vincristine_Zidovudine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Prednisone/Vincristine/Zidovudine|CTX/DOX/PRED/VCR/VP-16/ZDV
C10716	Interleukin-2_Monoclonal-Antibody-14G2A_Sargramostim	Chemotherapy_Regimen	Interleukin-2/Monoclonal Antibody 14G2A/Sargramostim|GM-CSF/IL-2/MOAB 14G2A
C10717	Cisplatin_Cytarabine_Etoposide_Prednisone	Chemotherapy_Regimen	Cisplatin/Cytarabine/Etoposide/Prednisone|ARA-C/CDDP/PRED/VP-16
C10718	Dexamethasone_Methotrexate_Thiotepa_Vincristine	Chemotherapy_Regimen	Dexamethasone/Methotrexate/Thiotepa/Vincristine|DM/MTX/TSPA/VCR
C10719	Carboplatin_Etoposide_Ifosfamide_Vincristine	Chemotherapy_Regimen	Carboplatin/Etoposide/Ifosfamide/Vincristine|CBDCA/IFF/VCR/VP-16
C10720	Busulfan_Cyclophosphamide_Cytarabine_Sargramostim	Chemotherapy_Regimen	Busulfan/Cyclophosphamide/Cytarabine/Sargramostim|ARA-C/BU/CTX/GM-CSF
C10721	Filgrastim_Fludarabine	Chemotherapy_Regimen	Filgrastim/Fludarabine|FAMP/G-CSF
C10722	Thioguanine_Tiazofurin	Chemotherapy_Regimen	Thioguanine/Tiazofurin|TCAR/TG
C10723	Filgrastim_Merbarone	Chemotherapy_Regimen	Filgrastim/Merbarone|G-CSF/MERB
C10724	Edatrexate_Paclitaxel	Chemotherapy_Regimen	Edatrexate/Paclitaxel|EDAM/TAX
C10725	Fluorouracil_Gallium-Nitrate	Chemotherapy_Regimen	Fluorouracil/Gallium Nitrate|5-FU/GAN
C10726	Paclitaxel_Quinine	Chemotherapy_Regimen	Paclitaxel/Quinine|QUIN/TAX
C10727	Floxuridine_Leucovorin-Calcium_PALA	Chemotherapy_Regimen	Floxuridine/Leucovorin Calcium/PALA|CF/FUDR/PALA
C10728	Cytarabine_Dexamethasone_Etoposide_Vincristine	Chemotherapy_Regimen	Cytarabine/Dexamethasone/Etoposide/Vincristine|ARA-C/DM/VCR/VP-16
C10729	Cyclophosphamide_Cytarabine_Daunorubicin_Thioguanine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Daunorubicin/Thioguanine|ARA-C/CTX/DNR/TG
C10730	Dexamethasone_Floxuridine_Mitomycin	Chemotherapy_Regimen	Dexamethasone/Floxuridine/Mitomycin|DM/FUDR/MITO
C10731	Cisplatin_Edatrexate_Ifosfamide	Chemotherapy_Regimen	Cisplatin/Edatrexate/Ifosfamide|CDDP/EDAM/IFF
C10732	Busulfan_Cyclophosphamide_Mitoxantrone	Chemotherapy_Regimen	Busulfan/Cyclophosphamide/Mitoxantrone|BU/CTX/DHAD
C10733	Floxuridine_Mitomycin	Chemotherapy_Regimen	Floxuridine/Mitomycin|FUDR/MITO
C10734	Doxorubicin_Topotecan	Chemotherapy_Regimen	Doxorubicin/Topotecan|DOX/TOPO
C10735	Methotrexate_Zidovudine	Chemotherapy_Regimen	Methotrexate/Zidovudine|MTX/ZDV
C10736	Daunorubicin_Methylprednisolone_Vincristine	Chemotherapy_Regimen	Daunorubicin/Methylprednisolone/Vincristine|DNR/MePRDL/VCR
C10737	Cytarabine_Methotrexate_Teniposide_Thioguanine	Chemotherapy_Regimen	Cytarabine/Methotrexate/Teniposide/Thioguanine|ARA-C/MTX/TG/VM-26
C10738	Asparaginase_Cyclophosphamide_Mercaptopurine_Methotrexate	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Mercaptopurine/Methotrexate|ASP/CTX/MP/MTX
C10739	Cytarabine_Mercaptopurine_Methotrexate_Teniposide_Thioguanine	Chemotherapy_Regimen	Cytarabine/Mercaptopurine/Methotrexate/Teniposide/Thioguanine|ARA-C/MP/MTX/TG/VM-26
C10740	Etoposide_Mitoxantrone_Prednisone_Vincristine	Chemotherapy_Regimen	Etoposide/Mitoxantrone/Prednisone/Vincristine|DHAD/PRED/VCR/VP-16
C10741	Carboplatin_Thiotepa	Chemotherapy_Regimen	Carboplatin/Thiotepa|CBDCA/TSPA
C10742	Cisplatin_Etoposide_Vincristine	Chemotherapy_Regimen	Cisplatin/Etoposide/Vincristine|CDDP/VCR/VP-16
C10743	Doxorubicin_Edatrexate	Chemotherapy_Regimen	Doxorubicin/Edatrexate|DOX/EDAM
C10744	Filgrastim_Tretinoin	Chemotherapy_Regimen	Filgrastim/Tretinoin|ATRA/G-CSF
C10745	Cyclophosphamide_Procarbazine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Procarbazine/Vincristine|CTX/PCB/VCR
C10746	Dexamethasone_Doxorubicin_Prednisone_Quinine_Vincristine	Chemotherapy_Regimen	Dexamethasone/Doxorubicin/Prednisone/Quinine/Vincristine|DM/DOX/PRED/QUIN/VCR
C10747	Dexamethasone_Doxorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Dexamethasone/Doxorubicin/Prednisone/Vincristine|DM/DOX/PRED/VCR
C10748	Estramustine_Etoposide	Chemotherapy_Regimen	Estramustine/Etoposide|EM/VP-16
C10749	Interferon-Beta_Isotretinoin	Chemotherapy_Regimen	Interferon Beta/Isotretinoin|13-CRA/IFN-B
C10750	Beta-Carotene_Vitamin-A	Chemotherapy_Regimen	Beta Carotene/Vitamin A|beta carotene/VIT-A
C10751	Dipyridamole_Fluorouracil_Leucovorin-Calcium_Mitomycin	Chemotherapy_Regimen	Dipyridamole/Fluorouracil/Leucovorin Calcium/Mitomycin|CF/DP/5-FU/MITO
C10752	Methotrexate_Paclitaxel	Chemotherapy_Regimen	Methotrexate/Paclitaxel|MTX/TAX
C10753	Filgrastim_Methotrexate_Paclitaxel	Chemotherapy_Regimen	Filgrastim/Methotrexate/Paclitaxel|G-CSF/MTX/TAX
C10754	Cyclophosphamide_Doxorubicin_Paclitaxel	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Paclitaxel|CTX/DOX/TAX
C10755	Cisplatin_Etoposide_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Cisplatin/Etoposide/Fluorouracil/Leucovorin Calcium|CDDP/CF/5-FU/VP-16
C10756	Etoposide_Ifosfamide_Melphalan	Chemotherapy_Regimen	Etoposide/Ifosfamide/Melphalan|IFF/L-PAM/VP-16
C10757	Cisplatin_Interleukin-1-Alpha	Chemotherapy_Regimen	Cisplatin/Interleukin-1-Alpha|CDDP/IL-1A
C10758	Carboplatin_Etoposide_Interleukin-6_Sargramostim	Chemotherapy_Regimen	Carboplatin/Etoposide/Interleukin-6/Sargramostim|CBDCA/GM-CSF/IL-6/VP-16
C10759	Ciprofloxacin_Cisplatin_Cyclophosphamide_Etoposide_Pentoxifylline	Chemotherapy_Regimen	Ciprofloxacin/Cisplatin/Cyclophosphamide/Etoposide/Pentoxifylline|CDDP/CPFX/CTX/PTX/VP-16
C10760	Carmustine_Cyclophosphamide_Etoposide_Melphalan	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Etoposide/Melphalan|BCNU/CTX/L-PAM/VP-16
C10761	Doxorubicin_Hydroxyurea	Chemotherapy_Regimen	Doxorubicin/Hydroxyurea|DOX/HU
C10762	Lomustine_Methotrexate	Chemotherapy_Regimen	Lomustine/Methotrexate|CCNU/MTX
C10763	Estramustine_Paclitaxel	Chemotherapy_Regimen	Estramustine/Paclitaxel|EM/TAX
C10764	Edatrexate_Filgrastim_Paclitaxel	Chemotherapy_Regimen	Edatrexate/Filgrastim/Paclitaxel|EDAM/G-CSF/TAX
C10765	Carboplatin_Etoposide_Ifosfamide_Milodistim	Chemotherapy_Regimen	Carboplatin/Etoposide/Ifosfamide/Milodistim|CBDCA/IFF/PIXY321/VP-16
C10766	Fluorouracil_Leucovorin-Calcium_Methotrexate_PALA_Triacetyluridine	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Methotrexate/PALA/Triacetyluridine|CF/5-FU/MTX/PALA/TAU
C10767	Fluorouracil_Leucovorin-Calcium_Paclitaxel	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Paclitaxel|CF/5-FU/TAX
C10768	Filgrastim_Fluorouracil_Leucovorin-Calcium_Paclitaxel	Chemotherapy_Regimen	Filgrastim/Fluorouracil/Leucovorin Calcium/Paclitaxel|CF/5-FU/G-CSF/TAX
C10769	Edatrexate_Leucovorin-Calcium	Chemotherapy_Regimen	Edatrexate/Leucovorin Calcium|CF/EDAM
C10770	Cyclosporine_Cytarabine_Etoposide_Mitoxantrone	Chemotherapy_Regimen	Cyclosporine/Cytarabine/Etoposide/Mitoxantrone|ARA-C/CYSP/DHAD/VP-16
C10771	Cyclophosphamide_Doxorubicin_Methotrexate_Methylprednisolone_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Methotrexate/Methylprednisolone/Prednisone/Vincristine|CTX/DOX/MePRDL/MTX/PRED/VCR
C10772	Cisplatin_Etoposide_Tamoxifen	Chemotherapy_Regimen	Cisplatin/Etoposide/Tamoxifen|CDDP/TMX/VP-16
C10773	BCG_Bropirimine	Chemotherapy_Regimen	BCG/Bropirimine|ABPP/BCG
C10774	Cyclophosphamide_Doxorubicin_Fluorouracil_Leucovorin-Calcium_Milodistim	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Leucovorin Calcium/Milodistim|CF/CTX/DOX/5-FU/PIXY321
C10775	Carboplatin_Fluorouracil_Vincristine	Chemotherapy_Regimen	Carboplatin/Fluorouracil/Vincristine|CBDCA/5-FU/VCR
C10776	Filgrastim_Pyrazoloacridine	Chemotherapy_Regimen	Filgrastim/Pyrazoloacridine|G-CSF/PZA
C10777	Filgrastim_Paclitaxel_Topotecan	Chemotherapy_Regimen	Filgrastim/Paclitaxel/Topotecan|G-CSF/TAX/TOPO
C10778	Cisplatin_Cyclosporine_Doxorubicin	Chemotherapy_Regimen	Cisplatin/Cyclosporine/Doxorubicin|CDDP/CYSP/DOX
C10779	Cisplatin_Pentoxifylline	Chemotherapy_Regimen	Cisplatin/Pentoxifylline|CDDP/PTX
C10780	Methotrexate_Pegaspargase	Chemotherapy_Regimen	Methotrexate/Pegaspargase|MTX/PEG-ASP
C10781	Cisplatin_Etoposide_Filgrastim_Ifosfamide_Interleukin-3	Chemotherapy_Regimen	Cisplatin/Etoposide/Filgrastim/Ifosfamide/Interleukin-3|CDDP/G-CSF/IFF/IL-3/VP-16
C10782	Cisplatin_Filgrastim_Ifosfamide_Interleukin-3_Vinblastine	Chemotherapy_Regimen	Cisplatin/Filgrastim/Ifosfamide/Interleukin-3/Vinblastine|CDDP/G-CSF/IFF/IL-3/VBL
C10783	Bleomycin_Cyclophosphamide_Doxorubicin_Prednisolone_Vindesine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Doxorubicin/Prednisolone/Vindesine|BLEO/CTX/DAVA/DOX/PRDL
C10784	Fazarabine_Filgrastim	Chemotherapy_Regimen	Fazarabine/Filgrastim|ARA-AC/G-CSF
C10785	Cyclophosphamide_Topotecan	Chemotherapy_Regimen	Cyclophosphamide/Topotecan|CTX/TOPO
C10786	Cisplatin_Cyclophosphamide_Thiotepa	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Thiotepa|CDDP/CTX/TSPA
C10787	Gallium-Nitrate_Ifosfamide_Vinblastine	Chemotherapy_Regimen	Gallium Nitrate/Ifosfamide/Vinblastine|GAN/IFF/VBL
C10788	Busulfan_Thiotepa	Chemotherapy_Regimen	Busulfan/Thiotepa|BU/TSPA
C10789	Mitoxantrone_Paclitaxel_Thiotepa	Chemotherapy_Regimen	Mitoxantrone/Paclitaxel/Thiotepa|DHAD/TAX/TSPA
C10790	Busulfan_Ciprofloxacin_Cyclophosphamide_Pentoxifylline	Chemotherapy_Regimen	Busulfan/Ciprofloxacin/Cyclophosphamide/Pentoxifylline|BU/CPFX/CTX/PTX
C10791	Busulfan_Melphalan_Thiotepa	Chemotherapy_Regimen	Busulfan/Melphalan/Thiotepa|BU/L-PAM/TSPA|BuMelT|BuMelt
C10792	Busulfan_ciprofloxacin_Melphalan_Pentoxifylline_Thiotepa	Chemotherapy_Regimen	Busulfan/Ciprofloxacin/Melphalan/Pentoxifylline/Thiotepa|BU/CPFX/L-PAM/PTX/TSPA
C10793	Carboxypeptidase-G2_Leucovorin-Calcium_Methotrexate	Chemotherapy_Regimen	Carboxypeptidase-G2/Leucovorin Calcium/Methotrexate|CF/CPG2/MTX
C10794	Asparaginase_Daunorubicin_Prednisolone_Vindesine	Chemotherapy_Regimen	Asparaginase/Daunorubicin/Prednisolone/Vindesine|ASP/DAVA/DNR/PRDL
C10795	Cytarabine_Etoposide_Ifosfamide_Methotrexate_Prednisolone	Chemotherapy_Regimen	Cytarabine/Etoposide/Ifosfamide/Methotrexate/Prednisolone|ARA-C/IFF/MTX/PRDL/VP-16
C10796	Doxorubicin_Prednisolone_Vincristine	Chemotherapy_Regimen	Doxorubicin/Prednisolone/Vincristine|DOX/PRDL/VCR
C10797	Cyclophosphamide_Prednisolone	Chemotherapy_Regimen	Cyclophosphamide/Prednisolone|CTX/PRDL
C10798	Cytarabine_Dexamethasone_Ifosfamide_Methotrexate_Teniposide_Vincristine	Chemotherapy_Regimen	Cytarabine/Dexamethasone/Ifosfamide/Methotrexate/Teniposide/Vincristine|ARA-C/DM/IFF/MTX/VCR/VM-26
C10799	Cytarabine_Dexamethasone_Etoposide_Vindesine	Chemotherapy_Regimen	Cytarabine/Dexamethasone/Etoposide/Vindesine|ARA-C/DAVA/DM/VP-16
C10800	Doxorubicin_Etoposide_Mitotane_Vincristine	Chemotherapy_Regimen	Doxorubicin/Etoposide/Mitotane/Vincristine|DDD/DOX/VCR/VP-16|MAVE
C10801	Cyclophosphamide_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Methotrexate|CTX/MTX
C10802	Carmustine_Dacarbazine_Thymidine	Chemotherapy_Regimen	Carmustine/Dacarbazine/Thymidine|BCNU/DTIC/TDR
C10803	Cytarabine_Ifosfamide	Chemotherapy_Regimen	Cytarabine/Ifosfamide|ARA-C/IFF
C10804	Cyclophosphamide_Indomethacin_Interleukin-2_Tumor-Infiltrating-Lymphocytes	Chemotherapy_Regimen	Cyclophosphamide/Indomethacin/Interleukin-2/Tumor Infiltrating Lymphocytes|CTX/IL-2/Indomethacin/TIL
C10805	Indomethacin_Interleukin-2_Lymphokine-Activated-Killer-Cells	Chemotherapy_Regimen	Indomethacin/Interleukin-2/Lymphokine-Activated Killer Cells|IL-2/Indomethacin/LAK
C10806	Hydroxyurea_Tretinoin	Chemotherapy_Regimen	Hydroxyurea/Tretinoin|ATRA/HU
C10807	Cisplatin_Vinorelbine	Chemotherapy_Regimen	Cisplatin/Vinorelbine|CDDP/VNB
C10808	Asparaginase_Vincristine	Chemotherapy_Regimen	Asparaginase/Vincristine|ASP/VCR
C10809	Dipyridamole_Methotrexate	Chemotherapy_Regimen	Dipyridamole/Methotrexate|DP/MTX
C10810	Cyclophosphamide_Epirubicin_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Epirubicin/Tamoxifen|CTX/EPI/TMX
C10811	Cyclophosphamide_Doxorubicin_Toremifene	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Toremifene|CTX/DOX/TOR
C10812	Cyclophosphamide_Epirubicin_Toremifene	Chemotherapy_Regimen	Cyclophosphamide/Epirubicin/Toremifene|CTX/EPI/TOR
C10813	Cytarabine_Dexamethasone_Etoposide_Ifosfamide_Methotrexate	Chemotherapy_Regimen	Cytarabine/Dexamethasone/Etoposide/Ifosfamide/Methotrexate|ARA-C/DM/IFF/MTX/VP-16
C10814	Cyclophosphamide_Dexamethasone_Doxorubicin_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Doxorubicin/Methotrexate|CTX/DM/DOX/MTX
C10815	Cyclophosphamide_Dexamethasone	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone|CTX/DM
C10816	Bryostatin-1_Tretinoin	Chemotherapy_Regimen	Bryostatin 1/Tretinoin|ATRA/BRYO
C10817	Floxuridine_Hydroxyurea_Leucovorin-Calcium	Chemotherapy_Regimen	Floxuridine/Hydroxyurea/Leucovorin Calcium|CF/FUDR/HU
C10818	Carboplatin_Cytarabine_Hydroxyurea	Chemotherapy_Regimen	Carboplatin/Cytarabine/Hydroxyurea|ARA-C/CBDCA/HU
C10819	Cyclophosphamide_Perflubron	Chemotherapy_Regimen	Cyclophosphamide/Perflubron|CTX/PFOB
C10820	Carboplatin_Topotecan	Chemotherapy_Regimen	Carboplatin/Topotecan|CBDCA/TOPO
C10821	Cytarabine_Topotecan	Chemotherapy_Regimen	Cytarabine/Topotecan|ARA-C/TOPO
C10822	Cyclophosphamide_Doxorubicin_Filgrastim_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Filgrastim/Fluorouracil/Leucovorin Calcium|CF/CTX/DOX/5-FU/G-CSF
C10823	Cisplatin_Etoposide_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Etoposide/Paclitaxel|CDDP/TAX/VP-16
C10824	Cisplatin_Etoposide_Filgrastim_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Etoposide/Filgrastim/Paclitaxel|CDDP/G-CSF/TAX/VP-16
C10825	Filgrastim_Penclomedine	Chemotherapy_Regimen	Filgrastim/Penclomedine|G-CSF/PEN
C10826	Doxorubicin_Methotrexate	Chemotherapy_Regimen	Doxorubicin/Methotrexate|DOX/MTX
C10827	Cisplatin_Doxorubicin_Methotrexate_Muramyl-TriPeptide-Phosphatidylethanolamine	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Methotrexate/Muramyl Tripeptide Phosphatidylethanolamine|CDDP/DOX/MTP-PE Liposome/MTX
C10828	Cisplatin_Ifosfamide_Muramyl-TriPeptide-Phosphatidylethanolamine	Chemotherapy_Regimen	Cisplatin/Ifosfamide/Muramyl Tripeptide Phosphatidylethanolamine|CDDP/IFF/MTP-PE Liposome
C10829	Carboplatin_Interleukin-6_Sargramostim	Chemotherapy_Regimen	Carboplatin/Interleukin-6/Sargramostim|CBDCA/GM-CSF/IL-6
C10830	Carboplatin_Filgrastim_Topotecan	Chemotherapy_Regimen	Carboplatin/Filgrastim/Topotecan|CBDCA/G-CSF/TOPO
C10831	Bleomycin_Cisplatin_Etoposide_Ifosfamide_Vinblastine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Etoposide/Ifosfamide/Vinblastine|BLEO/CDDP/IFF/VBL/VP-16
C10832	Cisplatin_Doxorubicin_Floxuridine_Leucovorin-Calcium	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Floxuridine/Leucovorin Calcium|CDDP/CF/DOX/FUDR
C10833	Cisplatin_Dexamethasone_Doxorubicin_Floxuridine_Leucovorin-Calcium	Chemotherapy_Regimen	Cisplatin/Dexamethasone/Doxorubicin/Floxuridine/Leucovorin Calcium|CDDP/CF/DM/DOX/FUDR
C10834	Cyclosporine_Dexamethasone_Vinblastine	Chemotherapy_Regimen	Cyclosporine/Dexamethasone/Vinblastine|CYSP/DM/VBL
C10835	Carboplatin_Cisplatin_Cyclophosphamide_Etoposide_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Cisplatin/Cyclophosphamide/Etoposide/Paclitaxel|CBDCA/CDDP/CTX/TAX/VP-16
C10836	Fluorouracil_Irinotecan_Leucovorin-Calcium	Chemotherapy_Regimen	Fluorouracil/Irinotecan/Leucovorin Calcium|5FU/Leucovorin/Irinotecan|CF/CPT-11/5-FU|IFL|Saltz Regimen
C10837	Gallium-Nitrate_Hydroxyurea	Chemotherapy_Regimen	Gallium Nitrate/Hydroxyurea|GAN/HU
C10838	Cyclophosphamide_Milodistim	Chemotherapy_Regimen	Cyclophosphamide/Milodistim|CTX/PIXY321
C10839	Carboplatin_Cyclophosphamide_Milodistim_Thiotepa	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Milodistim/Thiotepa|CBDCA/CTX/PIXY321/TSPA
C10840	Cytarabine_Doxorubicin_Prednisone_Thioguanine_Vincristine	Chemotherapy_Regimen	Cytarabine/Doxorubicin/Prednisone/Thioguanine/Vincristine|ARA-C/DOX/PRED/TG/VCR
C10841	Interleukin-1-Alpha_Methotrexate	Chemotherapy_Regimen	Interleukin-1-Alpha/Methotrexate|IL-1A/MTX
C10842	Lomustine_Vincristine	Chemotherapy_Regimen	Lomustine/Vincristine|CCNU/VCR
C10843	Interferon-Gamma_Interleukin-2_Melphalan_Tumor-Necrosis-Factor	Chemotherapy_Regimen	Interferon Gamma/Interleukin-2/Melphalan/Tumor Necrosis Factor|IFN-G/IL-2/L-PAM/TNF
C10844	Cyclophosphamide_Filgrastim_Topotecan	Chemotherapy_Regimen	Cyclophosphamide/Filgrastim/Topotecan|CTX/G-CSF/TOPO
C10845	Methotrexate_Procarbazine_Vincristine	Chemotherapy_Regimen	Methotrexate/Procarbazine/Vincristine|MTX/PCB/VCR
C10846	Cyclophosphamide_Idarubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Idarubicin/Prednisone/Vincristine|CTX/IDA/PRED/VCR
C10847	Carboplatin_Filgrastim_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Filgrastim/Paclitaxel|CBDCA/G-CSF/TAX
C10848	Asparaginase_Cytarabine_Filgrastim	Chemotherapy_Regimen	Asparaginase/Cytarabine/Filgrastim|ARA-C/ASP/G-CSF
C10849	Cisplatin_Etoposide_Filgrastim	Chemotherapy_Regimen	Cisplatin/Etoposide/Filgrastim|CDDP/G-CSF/VP-16
C10850	Ciprofloxacin_Cisplatin_Etoposide	Chemotherapy_Regimen	Ciprofloxacin/Cisplatin/Etoposide|CDDP/CPFX/VP-16
C10851	Ciprofloxacin_Cisplatin_Etoposide_filgrastim	Chemotherapy_Regimen	Ciprofloxacin/Cisplatin/Etoposide/Filgrastim|CDDP/CPFX/G-CSF/VP-16
C10852	Dacarbazine_Interleukin-1-Alpha	Chemotherapy_Regimen	Dacarbazine/Interleukin-1-Alpha|DTIC/IL-1A
C10853	Cyclophosphamide_Etoposide_Filgrastim	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Filgrastim|CTX/G-CSF/VP-16
C10854	Cytarabine_Milodistim_Mitoxantrone	Chemotherapy_Regimen	Cytarabine/Milodistim/Mitoxantrone|ARA-C/DHAD/PIXY321
C10855	Paclitaxel_PSC-833	Chemotherapy_Regimen	Paclitaxel/PSC 833|PSC 833/TAX|PSC/Paclitaxel
C10856	Cyclosporine_Methotrexate	Chemotherapy_Regimen	Cyclosporine/Methotrexate|CYSP/MTX
C10857	Dexamethasone_Vincristine	Chemotherapy_Regimen	Dexamethasone/Vincristine|DM/VCR
C10858	Etoposide_Interleukin-1-Alpha	Chemotherapy_Regimen	Etoposide/Interleukin-1-Alpha|IL-1A/VP-16
C10859	Carboplatin_Etoposide_Tamoxifen	Chemotherapy_Regimen	Carboplatin/Etoposide/Tamoxifen|CBDCA/TMX/VP-16
C10860	Cisplatin_Ifosfamide_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Ifosfamide/Paclitaxel|CDDP/IFF/TAX
C10861	Cyclophosphamide_Doxorubicin_Etoposide_Prednisone	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Prednisone|CTX/DOX/PRED/VP-16|PACE
C10862	Cytarabine_Homoharringtonine	Chemotherapy_Regimen	Cytarabine/Homoharringtonine|ARA-C/HH
C10863	Cytarabine_Mitoxantrone_Sargramostim	Chemotherapy_Regimen	Cytarabine/Mitoxantrone/Sargramostim|ARA-C/DHAD/GM-CSF
C10864	Cytarabine_Idarubicin_Sargramostim	Chemotherapy_Regimen	Cytarabine/Idarubicin/Sargramostim|ARA-C/GM-CSF/IDA
C10865	Aminocamptothecin_Filgrastim	Chemotherapy_Regimen	Aminocamptothecin/Filgrastim|9-AC/G-CSF
C10866	Bleomycin_Doxorubicin_Etoposide_Prednisolone_Vincristine	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Etoposide/Prednisolone/Vincristine|BLEO/DOX/PRDL/VCR/VP-16
C10867	Chlorambucil_Prednisolone_Procarbazine_Vinblastine	Chemotherapy_Regimen	Chlorambucil/Prednisolone/Procarbazine/Vinblastine|CLB/PCB/PRDL/VBL
C10868	Cisplatin_Cyclophosphamide_Etoposide_Filgrastim	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Etoposide/Filgrastim|CDDP/CTX/G-CSF/VP-16
C10869	Cisplatin_Cytarabine_Idarubicin_Methylprednisolone	Chemotherapy_Regimen	Cisplatin/Cytarabine/Idarubicin/Methylprednisolone|ARA-C/CDDP/IDA/MePRDL
C10870	Bleomycin_Idarubicin_Methylprednisolone_Vincristine	Chemotherapy_Regimen	Bleomycin/Idarubicin/Methylprednisolone/Vincristine|BLEO/CTX/IDA/MePRDL/VCR
C10871	Filgrastim_Interleukin-6	Chemotherapy_Regimen	Filgrastim/Interleukin-6|G-CSF/IL-6
C10872	Carboplatin_Etoposide_Filgrastim_Ifosfamide_Interleukin-6	Chemotherapy_Regimen	Carboplatin/Etoposide/Filgrastim/Ifosfamide/Interleukin-6|CBDCA/G-CSF/IFF/IL-6/VP-16
C10873	Cyclophosphamide_Topotecan_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Topotecan/Vincristine|CTX/TOPO/VCR
C10874	Dacarbazine_Doxorubicin_Filgrastim_Ifosfamide	Chemotherapy_Regimen	Dacarbazine/Doxorubicin/Filgrastim/Ifosfamide|DOX/DTIC/G-CSF/IFF
C10875	Carboplatin_Pentoxifylline	Chemotherapy_Regimen	Carboplatin/Pentoxifylline|CBDCA/PTX
C10876	Bleomycin_Cisplatin_Etoposide_Mitomycin	Chemotherapy_Regimen	Bleomycin/Cisplatin/Etoposide/Mitomycin|BLEO/CDDP/MITO/VP-16
C10877	Mitoxantrone_Paclitaxel	Chemotherapy_Regimen	Mitoxantrone/Paclitaxel|DHAD/TAX
C10878	Cisplatin_Tumor-Necrosis-Factor	Chemotherapy_Regimen	Cisplatin/Tumor Necrosis Factor|CDDP/TNF
C10879	Busulfan_Cyclophosphamide_Thiotepa	Chemotherapy_Regimen	Busulfan/Cyclophosphamide/Thiotepa|BU/CTX/TSPA
C10880	Cytarabine_Filgrastim_Idarubicin_Interleukin-6	Chemotherapy_Regimen	Cytarabine/Filgrastim/Idarubicin/Interleukin-6|ARA-C/G-CSF/IDA/IL-6
C10881	Cytarabine_Etoposide_Filgrastim_Interleukin-6_Mitoxantrone	Chemotherapy_Regimen	Cytarabine/Etoposide/Filgrastim/Interleukin-6/Mitoxantrone|ARA-C/DHAD/G-CSF/IL-6/VP-16
C10882	Cyclophosphamide_Filgrastim_Interleukin-6	Chemotherapy_Regimen	Cyclophosphamide/Filgrastim/Interleukin-6|CTX/G-CSF/IL-6
C10883	Carboplatin_Etoposide_Filgrastim_Ifosfamide_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Etoposide/Filgrastim/Ifosfamide/Paclitaxel|CBDCA/G-CSF/IFF/TAX/VP-16
C10884	Carboplatin_Etoposide_Ifosfamide_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Etoposide/Ifosfamide/Paclitaxel|CBDCA/IFF/TAX/VP-16
C10885	Melphalan_Paclitaxel	Chemotherapy_Regimen	Melphalan/Paclitaxel|L-PAM/TAX
C10886	Cyclophosphamide_Mitoxantrone_Prednisolone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Mitoxantrone/Prednisolone/Vincristine|CTX/DHAD/PRDL/VCR
C10887	Carboplatin_Cyclosporine_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Cyclosporine/Paclitaxel|CBDCA/CYSP/TAX
C10888	Cisplatin_Filgrastim_Topotecan	Chemotherapy_Regimen	Cisplatin/Filgrastim/Topotecan|CDDP/G-CSF/TOPO
C10889	Bleomycin_Cisplatin_Epoetin-Alfa_Etoposide_Filgrastim_Ifosfamide_Vinblastine	Chemotherapy_Regimen	Bleomycin/Cisplatin/Epoetin Alfa/Etoposide/Filgrastim/Ifosfamide/Vinblastine|BLEO/CDDP/EPO/G-CSF/IFF/VBL/VP-16
C10890	Cisplatin_Epoetin-Alfa_Etoposide_Filgrastim_Ifosfamide	Chemotherapy_Regimen	Cisplatin/Epoetin Alfa/Etoposide/Filgrastim/Ifosfamide|CDDP/EPO/G-CSF/IFF/VP-16
C10891	Carboplatin_Filgrastim_Interleukin-6_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Filgrastim/Interleukin-6/Paclitaxel|CBDCA/G-CSF/IL-6/TAX
C10892	Benznidazole_Lomustine	Chemotherapy_Regimen	Benznidazole/Lomustine|benznidazole/CCNU
C10893	Flutamide_Goserelin_Suramin	Chemotherapy_Regimen	Flutamide/Goserelin/Suramin|FLUT/SUR/ZDX
C10894	Carboplatin_Etoposide_Vincristine	Chemotherapy_Regimen	Carboplatin/Etoposide/Vincristine|CBDCA/VCR/VP-16
C10895	Doxorubicin_Filgrastim_Ifosfamide	Chemotherapy_Regimen	Doxorubicin/Filgrastim/Ifosfamide|DOX/G-CSF/IFF
C10896	Goserelin_Tamoxifen	Chemotherapy_Regimen	Goserelin/Tamoxifen|TMX/ZDX
C10897	Leuprolide_Tamoxifen	Chemotherapy_Regimen	Leuprolide/Tamoxifen|LEUP/TMX
C10898	Cyclophosphamide_Fluorouracil_Leuprolide_Methotrexate_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Leuprolide/Methotrexate/Tamoxifen|CTX/5-FU/LEUP/MTX/TMX
C10899	Cyclophosphamide_Fluorouracil_Goserelin_Methotrexate_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Goserelin/Methotrexate/Tamoxifen|CTX/5-FU/MTX/TMX/ZDX
C10900	Cyclophosphamide_Doxorubicin_Leuprolide_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Leuprolide/Tamoxifen|CTX/DOX/LEUP/TMX
C10901	Cyclophosphamide_Doxorubicin_Goserelin_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Goserelin/Tamoxifen|CTX/DOX/TMX/ZDX
C10902	Asparaginase_Cytarabine_Etoposide_Methotrexate_Prednisone_Thioguanine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Etoposide/Methotrexate/Prednisone/Thioguanine/Vincristine|ARA-C/ASP/MTX/PRED/TG/VCR/VP-16
C10903	Altretamine_Etoposide	Chemotherapy_Regimen	Altretamine/Etoposide|HMM/VP-16
C10904	Dexamethasone_Dexniguldipine_Doxorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Dexamethasone/Dexniguldipine/Doxorubicin/Prednisone/Vincristine|DM/DNIG/DOX/PRED/VCR
C10905	Dexamethasone_Dexniguldipine_Doxorubicin_Vincristine	Chemotherapy_Regimen	Dexamethasone/Dexniguldipine/Doxorubicin/Vincristine|DM/DNIG/DOX/VCR
C10906	Filgrastim_Stem-Cell-Factor	Retired_Concepts	Filgrastim/Stem Cell Factor|G-CSF/SCF
C10907	Gallium-Nitrate_Paclitaxel	Chemotherapy_Regimen	Gallium Nitrate/Paclitaxel|GAN/TAX
C10908	Filgrastim_Gallium-Nitrate_Paclitaxel	Chemotherapy_Regimen	Filgrastim/Gallium Nitrate/Paclitaxel|GAN/G-CSF/TAX
C10909	Paclitaxel_Thiotepa	Chemotherapy_Regimen	Paclitaxel/Thiotepa|TAX/TSPA
C10910	Carmustine_O6-Benzylguanine	Chemotherapy_Regimen	Carmustine/O6-Benzylguanine|BCNU/BG
C10911	Cyclophosphamide_Didanosine_Doxorubicin_Etoposide	Chemotherapy_Regimen	Cyclophosphamide/Didanosine/Doxorubicin/Etoposide|CTX/ddI/DOX/VP-16
C10912	Antineoplaston-A10_Antineoplaston-AS2-1	Chemotherapy_Regimen	Antineoplaston A10/Antineoplaston AS2-1|A10/AS2-1
C10913	Cisplatin_Cytarabine_Dexamethasone_Idarubicin	Chemotherapy_Regimen	Cisplatin/Cytarabine/Dexamethasone/Idarubicin|ARA-C/CDDP/DM/IDA
C10914	Cisplatin_Cytarabine_Dexamethasone_Idarubicin_Methotrexate	Chemotherapy_Regimen	Cisplatin/Cytarabine/Dexamethasone/Idarubicin/Methotrexate|ARA-C/CDDP/DM/IDA/MTX
C10915	Etoposide_Fluorouracil	Chemotherapy_Regimen	Etoposide/Fluorouracil|5-FU/VP-16
C10916	Carboplatin_Milodistim_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Milodistim/Paclitaxel|CBDCA/PIXY321/TAX
C10917	Cisplatin_Dacarbazine_Interleukin-2_Vinblastine	Chemotherapy_Regimen	Cisplatin/Dacarbazine/Interleukin-2/Vinblastine|CDDP/DTIC/IL-2/VBL
C10918	Cytarabine_Filgrastim_Idarubicin	Chemotherapy_Regimen	Cytarabine/Filgrastim/Idarubicin|ARA-C/G-CSF/IDA
C10919	Cytarabine_Etoposide_Filgrastim_Mitoxantrone	Chemotherapy_Regimen	Cytarabine/Etoposide/Filgrastim/Mitoxantrone|ARA-C/DHAD/G-CSF/VP-16
C10920	Dexamethasone_Methotrexate_Procarbazine_Vincristine	Chemotherapy_Regimen	Dexamethasone/Methotrexate/Procarbazine/Vincristine|DM/MTX/PCB/VCR
C10921	Carboplatin_Cyclophosphamide_Filgrastim	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Filgrastim|CBDCA/CTX/G-CSF
C10922	Cisplatin_Pyrazoloacridine	Chemotherapy_Regimen	Cisplatin/Pyrazoloacridine|CDDP/PZA
C10923	Cisplatin_Filgrastim_Pyrazoloacridine	Chemotherapy_Regimen	Cisplatin/Filgrastim/Pyrazoloacridine|CDDP/G-CSF/PZA
C10924	Carboxyamidotriazole_Paclitaxel	Chemotherapy_Regimen	Carboxyamidotriazole/Paclitaxel|CAI/Paclitaxel|CAI/TAX
C10925	Cyclophosphamide_Doxorubicin_Methylprednisolone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Methylprednisolone/Vincristine|CTX/DOX/MePRDL/VCR
C10926	BMS-182751_Etoposide	Chemotherapy_Regimen	BMS-182751/Etoposide|BMS-182751/VP-16
C10927	Cyclophosphamide_Dexamethasone_Doxorubicin_Etoposide	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Doxorubicin/Etoposide|CTX/DM/DOX/VP-16
C10928	Isotretinoin_Vitamine-E	Chemotherapy_Regimen	Isotretinoin/Vitamin E|13-CRA/VIT-E
C10929	Dexverapamil_Vinblastine	Chemotherapy_Regimen	Dexverapamil/Vinblastine|R-VPAM/VBL
C10930	Cisplatin_Docetaxel_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Cisplatin/Docetaxel/Fluorouracil/Leucovorin Calcium|CDDP/CF/5-FU/TXT
C10931	Cisplatin_Doxorubicin_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Paclitaxel|CDDP/DOX/TAX
C10932	Cisplatin_Doxorubicin_Filgrastim_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Filgrastim/Paclitaxel|CDDP/DOX/G-CSF/TAX
C10933	Etoposide_Mitoxantrone_Sargramostim	Chemotherapy_Regimen	Etoposide/Mitoxantrone/Sargramostim|DHAD/GM-CSF/VP-16
C10934	Etoposide_Novobiocin	Chemotherapy_Regimen	Etoposide/Novobiocin|NBC/VP-16
C10935	Cisplatin_Tirapazamine	Chemotherapy_Regimen	Cisplatin/Tirapazamine|CDDP/SR-4233
C10936	Bleomycin_Cyclophosphamide_Doxorubicin_Prednisone_Procarbazine_Vinblastine_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Doxorubicin/Prednisone/Procarbazine/Vinblastine/Vincristine|BLEO/CTX/DOX/PCB/PRED/VBL/VCR
C10937	Cisplatin_Epirubicin_Fluorouracil	Chemotherapy_Regimen	Cisplatin/Epirubicin/Fluorouracil|CDDP/EPI/5-FU
C10938	Prednisone_Thioguanine_Vincristine	Chemotherapy_Regimen	Prednisone/Thioguanine/Vincristine|PRED/TG/VCR
C10939	Carboplatin_Etoposide_Mitoxantrone_Thiotepa	Chemotherapy_Regimen	Carboplatin/Etoposide/Mitoxantrone/Thiotepa|CBDCA/DHAD/TSPA/VP-16
C10940	CI-980_Filgrastim	Chemotherapy_Regimen	CI-980/Filgrastim|CI-980/G-CSF
C10941	Dexamethasone_Etoposide_Ifosfamide_Methotrexate_Pegaspargase_Vincristine	Chemotherapy_Regimen	Dexamethasone/Etoposide/Ifosfamide/Methotrexate/Pegaspargase/Vincristine|DM/IFF/MTX/PEG-ASP/VCR/VP-16
C10942	Cytarabine_Dexamethasone_Etoposide_Idarubicin_Ifosfamide_Methotrexate_Pegaspargase_Thioguanine_Vincristine	Chemotherapy_Regimen	Cytarabine/Dexamethasone/Etoposide/Idarubicin/Ifosfamide/Methotrexate/Pegaspargase/Thioguanine/Vincristine|ARA-C/DM/IDA/IFF/MTX/PEG-ASP/TG/VCR/VP-16
C10943	Cytarabine_Dexamethasone_Etoposide_Methotrexate_Pegaspargase_Thioguanine_Vincristine	Chemotherapy_Regimen	Cytarabine/Dexamethasone/Etoposide/Methotrexate/Pegaspargase/Thioguanine/Vincristine|ARA-C/DM/MTX/PEG-ASP/TG/VCR/VP-16
C10944	Dexamethasone_Idarubicin_Ifosfamide_Methotrexate_Thioguanine_Vincristine	Chemotherapy_Regimen	Dexamethasone/Idarubicin/Ifosfamide/Methotrexate/Thioguanine/Vincristine|DM/IDA/IFF/MTX/TG/VCR
C10945	Methotrexate_Thioguanine_Vincristine	Chemotherapy_Regimen	Methotrexate/Thioguanine/Vincristine|MTX/TG/VCR
C10946	Carmustine_Mitolactol	Chemotherapy_Regimen	Carmustine/Mitolactol|BCNU/DBD
C10947	Interleukin-2_Monoclonal-Antibody-Ch14-18_Monoclonal-Antibody-R24	Chemotherapy_Regimen	Interleukin-2/Monoclonal Antibody Ch14.18/Monoclonal Antibody R24|IL-2/MOAB Ch14.18/MOAB R24
C10948	Carboplatin_Cyclophosphamide_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Paclitaxel|CBDCA/CTX/TAX
C10949	Carboplatin_Cyclophosphamide_Filgrastim_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Filgrastim/Paclitaxel|CBDCA/CTX/G-CSF/TAX
C10950	Cisplatin_Epoetin-Alfa_Iron	Chemotherapy_Regimen	Cisplatin/Epoetin Alfa/Iron|CDDP/EPO/iron
C10951	Detox_Keyhole-Limpet-Hemocyanin_Sialyl-Tn-Antigen	Chemotherapy_Regimen	Detox/Keyhole Limpet Hemocyanin/Sialyl Tn Antigen|DETOX/KLH/STn antigen
C10952	CT-1501R_Interleukin-2	Chemotherapy_Regimen	CT-1501R/Interleukin-2|CT-1501R/IL-2
C10953	ImmTher_Indomethacin	Chemotherapy_Regimen	ImmTher/Indomethacin
C10954	Cisplatin_Safingol	Chemotherapy_Regimen	Cisplatin/Safingol|CDDP/safingol
C10955	Doxorubicin_Ketoconazole	Chemotherapy_Regimen	Doxorubicin/Ketoconazole|DOX/KCZ
C10956	Cytarabine_Dexamethasone_Etoposide_Idarubicin_Thioguanine	Chemotherapy_Regimen	Cytarabine/Dexamethasone/Etoposide/Idarubicin/Thioguanine|ARA-C/DM/IDA/TG/VP-16|IDA DCTER
C10957	Cisplatin_Cyclophosphamide_Filgrastim_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Filgrastim/Paclitaxel|CDDP/CTX/G-CSF/TAX|Cisplatin/Pacli/Cyclo/GCSF
C10958	Hydroxyurea_Pentoxifylline	Chemotherapy_Regimen	Hydroxyurea/Pentoxifylline|HU/PTX
C10959	Flutamide_Isotretinoin_Leuprolide	Chemotherapy_Regimen	Flutamide/Isotretinoin/Leuprolide|13-CRA/FLUT/LEUP
C10960	Interleukin-2_MART-1-Antigen	Chemotherapy_Regimen	Interleukin-2/MART-1 Antigen|IL-2/MART-1
C10961	Cisplatin_Irinotecan	Chemotherapy_Regimen	Cisplatin/Irinotecan|CDDP/CPT-11
C10962	Cisplatin_Doxorubicin_Tamoxifen	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Tamoxifen|CDDP/DOX/TMX
C10963	Etoposide_Mitoxantrone_PSC-833	Chemotherapy_Regimen	Etoposide/Mitoxantrone/PSC 833|DHAD/PSC 833/VP-16
C10964	Estramustine_Vinorelbine	Chemotherapy_Regimen	Estramustine/Vinorelbine|EM/VNB
C10965	Folic-Acid_Lometrexol	Chemotherapy_Regimen	Folic Acid/Lometrexol|FA/LMTX
C10966	Cisplatin_Docetaxel	Chemotherapy_Regimen	Cisplatin/Docetaxel|CDDP/TXT
C10967	Bleomycin_Cisplatin_Cyclophosphamide_Etoposide	Chemotherapy_Regimen	Bleomycin/Cisplatin/Cyclophosphamide/Etoposide|BLEO/CDDP/CTX/VP-16
C10968	Carmustine_Temozolomide	Chemotherapy_Regimen	Carmustine/Temozolomide|BCNU/TMZ
C10969	Fluorouracil_Levamisole_L-Leucovorin	Chemotherapy_Regimen	Fluorouracil/Levamisole/L-Leucovorin|5-FU/L-CF/LEV
C10970	Carbogen_Niacinamide	Chemotherapy_Regimen	Carbogen/Niacinamide|NICOGEN/UN1014
C10971	Leucovorin-Calcium_Tegafur_Uracil	Chemotherapy_Regimen	Leucovorin Calcium/Tegafur/Uracil|CF/UFT
C10972	Fludarabine_Mitoxantrone	Chemotherapy_Regimen	Fludarabine/Mitoxantrone|DHAD/FAMP
C10973	Ifosfamide_Vinorelbine	Chemotherapy_Regimen	Ifosfamide/Vinorelbine|IFF/VNB
C10974	Fluorouracil_L-Leucovorin_Methotrexate	Chemotherapy_Regimen	Fluorouracil/L-Leucovorin/Methotrexate|5-FU/L-CF/MTX
C10975	Cytarabine_Daunorubicin_Etoposide_Filgrastim	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Etoposide/Filgrastim|ARA-C/DNR/G-CSF/VP-16
C10976	Busulfan_Cytarabine_Melphalan	Chemotherapy_Regimen	Busulfan/Cytarabine/Melphalan|ARA-C/BU/L-PAM
C10977	Dexverapamil_Doxorubicin	Chemotherapy_Regimen	Dexverapamil/Doxorubicin|DOX/R-VPAM
C10978	Daunorubicin_Pegaspargase_Prednisone_Vincristine	Chemotherapy_Regimen	Daunorubicin/Pegaspargase/Prednisone/Vincristine|DNR/PEG-ASP/PRED/VCR
C10979	Daunorubicin_Milodistim_Pegaspargase_Prednisone_Vincristine	Chemotherapy_Regimen	Daunorubicin/Milodistim/Pegaspargase/Prednisone/Vincristine|DNR/PEG-ASP/PIXY321/PRED/VCR
C10980	Interleukin-2_NG-Monomethyl-L-Arginine	Chemotherapy_Regimen	Interleukin-2/NG-Monomethyl-L-Arginine|IL-2/NMA
C10981	Leucovorin-Calcium_Trimetrexate-Glucuronate	Chemotherapy_Regimen	Leucovorin Calcium/Trimetrexate Glucuronate|CF/TMTX
C10982	Cyclophosphamide_Fluorouracil_Pirarubicin	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Pirarubicin|CTX/5-FU/THP-DOX
C10983	Dacarbazine_Pirarubicin	Chemotherapy_Regimen	Dacarbazine/Pirarubicin|DTIC/THP-DOX
C10984	Zalcitabine_Zidovudine	Chemotherapy_Regimen	Zalcitabine/Zidovudine|ddC/ZDV
C10985	Cyclophosphamide_Interferon-Alfa_Interleukin-2	Chemotherapy_Regimen	Cyclophosphamide/Interferon Alfa/Interleukin-2|CTX/IFN-A/IL-2
C10986	Interferon-Alfa_Vinblastine	Chemotherapy_Regimen	Interferon Alfa/Vinblastine|IFN-A/VBL
C10987	Fluorouracil_Interferon-Alfa	Chemotherapy_Regimen	Fluorouracil/Interferon Alfa|5-FU/IFN-A|5FU/Interferon|IFN/5FU
C10988	Interferon-Alfa_Sargramostim_Zidovudine	Chemotherapy_Regimen	Interferon Alfa/Sargramostim/Zidovudine|GM-CSF/IFN-A/ZDV
C10989	Doxorubicin_eflornithine_Interferon-Alfa	Chemotherapy_Regimen	Doxorubicin/eflornithine/Interferon Alfa|DFMO/DOX/IFN-A
C10990	Interferon-Alfa_Prednisone	Chemotherapy_Regimen	Interferon Alfa/Prednisone|IFN-A/PRED
C10991	Interferon-Alfa_Tamoxifen	Chemotherapy_Regimen	Interferon Alfa/Tamoxifen|IFN-A/TMX
C10992	Fluorouracil_Interferon-Alfa_Mitomycin	Chemotherapy_Regimen	Fluorouracil/Interferon Alfa/Mitomycin|5-FU/IFN-A/MITO
C10993	Eflornithine_Interferon-Alfa	Chemotherapy_Regimen	Eflornithine/Interferon Alfa|DFMO/IFN-A
C10994	Interferon-Alfa_Interleukin-2_Tumor-Infiltrating-Lymphocytes	Chemotherapy_Regimen	Interferon Alfa/interleukin-2/Tumor Infiltrating Lymphocytes|IFN-A/IL-2/TIL
C10995	Dexamethasone_Doxorubicin_Interferon-Alfa_Vincristine	Chemotherapy_Regimen	Dexamethasone/Doxorubicin/Interferon Alfa/Vincristine|DM/DOX/IFN-A/VCR
C10996	Cisplatin_Interferon-Alfa_Interleukin-2	Chemotherapy_Regimen	Cisplatin/Interferon Alfa/interleukin-2|CDDP/IFN-A/IL-2
C10997	Cyclophosphamide_Doxorubicin_Interferon-Alfa_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Interferon Alfa/Prednisone/Vincristine|CTX/DOX/IFN-A/PRED/VCR|I-COPA
C10998	Fluorouracil_Interferon-Alfa_PALA	Chemotherapy_Regimen	Fluorouracil/Interferon Alfa/PALA|5-FU/IFN-A/PALA
C10999	Mitoxantrone_Interferon-Alfa	Chemotherapy_Regimen	Mitoxantrone/Interferon Alfa|DHAD/IFN-A
C11000	Interferon-Alfa_Zidovudine	Chemotherapy_Regimen	Interferon Alfa/Zidovudine|IFN-A/ZDV
C11001	Lomustine_Interferon-Alfa	Chemotherapy_Regimen	Lomustine/Interferon Alfa|CCNU/IFN-A
C11002	Cyclophosphamide_Interferon-Alfa_Interleukin-2_Tumor-Infiltrating-Lymphocytes	Chemotherapy_Regimen	Cyclophosphamide/Interferon Alfa/interleukin-2/Tumor Infiltrating Lymphocytes|CTX/IFN-A/IL-2/TIL
C11003	Interferon-Alfa_Piroxicam	Chemotherapy_Regimen	Interferon Alfa/Piroxicam|IFN-A/PXM
C11004	Cyclophosphamide_Interferon-Alfa_Prednisone	Chemotherapy_Regimen	Cyclophosphamide/Interferon Alfa/Prednisone|CTX/IFN-A/PRED
C11005	Cisplatin_Interferon-Alfa	Chemotherapy_Regimen	Cisplatin/Interferon Alfa|CDDP/IFN-A|Cisplatin/Interferon
C11006	Interferon-Alfa_Interferon-Gamma	Chemotherapy_Regimen	Interferon Alfa/Interferon Gamma|IFN-A/IFN-G
C11007	Doxorubicin_Interferon-Alfa	Chemotherapy_Regimen	Doxorubicin/Interferon Alfa|DOX/IFN-A
C11008	Interferon-Alfa_Interleukin-2	Chemotherapy_Regimen	Interferon Alfa/Interleukin-2|IFN-A/IL-2
C11009	Interferon-Alfa_Isotretinoin	Chemotherapy_Regimen	Interferon Alfa/Isotretinoin|13-CRA/IFN-A
C11010	Carmustine_Interferon-Alfa	Chemotherapy_Regimen	Carmustine/Interferon Alfa|BCNU/IFN-A
C11011	Cyclophosphamide_Interferon-Alfa	Chemotherapy_Regimen	Cyclophosphamide/Interferon Alfa|CTX/IFN-A
C11012	Interferon-Alfa_Mercaptopurine_Methotrexate	Chemotherapy_Regimen	Interferon Alfa/Mercaptopurine/Methotrexate|IFN-A/MP/MTX
C11013	Interferon-Alfa_Interleukin-2_Lymphokine-Activated-Killer-Cells	Chemotherapy_Regimen	Interferon Alfa/Interleukin-2/Lymphokine-Activated Killer Cells|IFN-A/IL-2/LAK|IL2/LAK/IFN
C11014	Fluorouracil_Interferon-Alfa_Leucovorin-Calcium	Chemotherapy_Regimen	Fluorouracil/Interferon Alfa/Leucovorin Calcium|CF/5-FU/IFN-A|IFN/5FU/Leucovorin
C11015	Carmustine_Cyclophosphamide_Interferon-Alfa_Melphalan_Prednisone_Vincristine	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Interferon Alfa/Melphalan/Prednisone/Vincristine|BCNU/CTX/IFN-A/L-PAM/PRED/VCR
C11016	Cisplatin_Interferon-Alfa_Tamoxifen	Chemotherapy_Regimen	Cisplatin/Interferon Alfa/Tamoxifen|CDDP/IFN-A/TMX
C11017	Interferon-Alfa_Melphalan_Prednisone	Chemotherapy_Regimen	Interferon Alfa/Melphalan/Prednisone|IFN-A/L-PAM/PRED
C11018	Interferon-Alfa_Poly-ICLC	Chemotherapy_Regimen	Interferon Alfa/Poly ICLC|IFN-A/Poly ICLC
C11019	Cisplatin_Cyclophosphamide_Interferon-Alfa	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Interferon Alfa|CDDP/CTX/IFN-A
C11020	Cisplatin_Etoposide_Interferon-Alfa	Chemotherapy_Regimen	Cisplatin/Etoposide/Interferon Alfa|CDDP/IFN-A/VP-16
C11021	Carboplatin_Interferon-Alfa	Chemotherapy_Regimen	Carboplatin/Interferon Alfa|CBDCA/IFN-A
C11022	Cyclophosphamide_Interferon-Alfa_Melphalan_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Interferon Alfa/Melphalan/Prednisone/Vincristine|CTX/IFN-A/L-PAM/PRED/VCR
C11023	Carmustine_Cisplatin_Dacarbazine_Interferon-Alfa_Tamoxifen	Chemotherapy_Regimen	Carmustine/Cisplatin/Dacarbazine/Interferon Alfa/Tamoxifen|BCNU/CDDP/DTIC/IFN-A/TMX
C11024	Floxuridine_Fluorouracil_Interferon-Alfa_Leucovorin-Calcium	Chemotherapy_Regimen	Floxuridine/Fluorouracil/Interferon Alfa/Leucovorin Calcium|CF/5-FU/FUDR/IFN-A
C11025	Floxuridine_Interferon-Alfa_Mitomycin	Chemotherapy_Regimen	Floxuridine/Interferon Alfa/Mitomycin|FUDR/IFN-A/MITO
C11026	Cisplatin_Fluorouracil_Interferon-Alfa_Leucovorin-Calcium	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Interferon Alfa/Leucovorin Calcium|CDDP/CF/5-FU/IFN-A
C11027	Fluorouracil_Interferon-Alfa_Interleukin-2	Chemotherapy_Regimen	Fluorouracil/Interferon Alfa/Interleukin-2|5-FU/IFN-A/IL-2|IFN/5FU/IL2
C11028	Cytarabine_Interferon-Alfa	Chemotherapy_Regimen	Cytarabine/Interferon Alfa|ARA-C/IFN-A
C11029	Fludarabine_Interferon-Alfa	Chemotherapy_Regimen	Fludarabine/Interferon Alfa|FAMP/IFN-A
C11030	Fluorouracil_Interferon-Alfa_Leucovorin-Calcium_Methotrexate	Chemotherapy_Regimen	Fluorouracil/Interferon Alfa/Leucovorin Calcium/Methotrexate|CF/5-FU/IFN-A/MTX
C11031	Cisplatin_Interferon-Alfa_Interleukin-2_Vinblastine	Chemotherapy_Regimen	Cisplatin/Interferon Alfa/interleukin-2/Vinblastine|CDDP/IFN-A/IL-2/VBL
C11032	Cisplatin_Fluorouracil_Interferon-Alfa	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Interferon Alfa|CDDP/5-FU/IFN-A
C11033	Dacarbazine_Interferon-Alfa	Chemotherapy_Regimen	Dacarbazine/Interferon Alfa|DTIC/IFN-A
C11034	Dacarbazine_Interferon-Alfa_Tamoxifen	Chemotherapy_Regimen	Dacarbazine/Interferon Alfa/Tamoxifen|DTIC/IFN-A/TMX
C11035	Carboplatin_Cisplatin_Interferon-Alfa_Tamoxifen	Chemotherapy_Regimen	Carboplatin/Cisplatin/Interferon Alfa/Tamoxifen|CBDCA/CDDP/IFN-A/TMX
C11036	Interferon-Alfa_Interleukin-2_Monoclonal-Antibody-R24	Chemotherapy_Regimen	Interferon Alfa/Interleukin-2/Monoclonal Antibody R24|IFN-A/IL-2/MOAB R24
C11037	Filgrastim_Fluorouracil_Interferon-Alfa	Chemotherapy_Regimen	Filgrastim/Fluorouracil/Interferon Alfa|5-FU/G-CSF/IFN-A
C11038	Cyclophosphamide_Doxorubicin_Fluorouracil_Interferon-Alfa	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Fluorouracil/Interferon Alfa|CTX/DOX/5-FU/IFN-A
C11039	Interferon-Alfa_Interleukin-2_Tumor-Necrosis-Factor	Chemotherapy_Regimen	Interferon Alfa/Interleukin-2/Tumor Necrosis Factor|IFN-A/IL-2/TNF
C11040	Chlorambucil_Interferon-Alfa	Chemotherapy_Regimen	Chlorambucil/Interferon Alfa|CLB/IFN-A
C11041	Cisplatin_Cyclophosphamide_Doxorubicin_Etoposide_filgrastim	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Etoposide/Filgrastim|CDDP/CTX/DOX/G-CSF/VP-16
C11042	Hydroxyurea_Interferon-Alfa	Chemotherapy_Regimen	Hydroxyurea/Interferon Alfa|HU/IFN-A
C11043	Carboplatin_Etoposide_Interferon-Alfa_Mitoxantrone	Chemotherapy_Regimen	Carboplatin/Etoposide/Interferon Alfa/Mitoxantrone|CBDCA/DHAD/IFN-A/VP-16
C11044	Interferon-Alfa_Megestrol_Tamoxifen	Chemotherapy_Regimen	Interferon Alfa/Megestrol/Tamoxifen|IFN-A/MEG/TMX
C11045	Fluorouracil_Interferon-Alfa_Leucovorin-Calcium_Mitomycin	Chemotherapy_Regimen	Fluorouracil/Interferon Alfa/Leucovorin Calcium/Mitomycin|CF/5-FU/IFN-A/MITO
C11046	Floxuridine_Interferon-Alfa	Chemotherapy_Regimen	Floxuridine/Interferon Alfa|FUDR/IFN-A
C11047	Cisplatin_Etoposide_Fluorouracil_Interferon-Alfa	Chemotherapy_Regimen	Cisplatin/Etoposide/Fluorouracil/Interferon Alfa|CDDP/5-FU/IFN-A/VP-16
C11048	Allopurinol_Fluorouracil_Interferon-Alfa	Chemotherapy_Regimen	Allopurinol/Fluorouracil/Interferon Alfa|ALLO/5-FU/IFN-A
C11049	Interferon-Alfa_Tretinoin	Chemotherapy_Regimen	Interferon Alfa/Tretinoin|ATRA/IFN-A
C11050	Fluorouracil_Interferon-Alfa_Interferon-Gamma_Leucovorin-Calcium	Chemotherapy_Regimen	Fluorouracil/Interferon Alfa/Interferon Gamma/Leucovorin Calcium|CF/5-FU/IFN-A/IFN-G
C11051	Bleomycin_Doxorubicin_Vincristine_Zalcitabine	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Vincristine/zalcitabine|BLEO/ddC/DOX/VCR
C11052	Bleomycin_Cisplatin_Ifosfamide_Interferon-Alfa	Chemotherapy_Regimen	Bleomycin/Cisplatin/Ifosfamide/Interferon Alfa|BLEO/CDDP/IFF/IFN-A
C11053	Interferon-Alfa_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Interferon Alfa/Mercaptopurine/Methotrexate/Prednisone/Vincristine|IFN-A/MP/MTX/PRED/VCR
C11054	Busulfan_Interferon-Alfa	Chemotherapy_Regimen	Busulfan/Interferon Alfa|BU/IFN-A
C11055	Filgrastim_Interferon-Alfa	Chemotherapy_Regimen	Filgrastim/Interferon Alfa|G-CSF/IFN-A
C11056	Hydralazine_Interferon-Alfa	Chemotherapy_Regimen	Hydralazine/Interferon Alfa|hydralazine/IFN-A
C11057	Carmustine_Fluorouracil_Interferon-Alfa	Chemotherapy_Regimen	Carmustine/Fluorouracil/Interferon Alfa|BCNU/5-FU/IFN-A
C11058	Carmustine_Doxorubicin_Interferon-Alfa_Prednisone_Vincristine	Chemotherapy_Regimen	Carmustine/Doxorubicin/Interferon Alfa/Prednisone/Vincristine|BCNU/DOX/IFN-A/PRED/VCR
C11059	Busulfan_Cyclophosphamide_Interferon-Alfa_Zidovudine	Chemotherapy_Regimen	Busulfan/Cyclophosphamide/Interferon Alfa/Zidovudine|BU/CTX/IFN-A/ZDV
C11060	Fluorouracil_Hydroxyurea_Interferon-Alfa	Chemotherapy_Regimen	Fluorouracil/Hydroxyurea/Interferon Alfa|5-FU/HU/IFN-A
C11061	Doxorubicin_Interferon-Alfa_Tretinoin	Chemotherapy_Regimen	Doxorubicin/Interferon Alfa/Tretinoin|ATRA/DOX/IFN-A
C11062	Cisplatin_Dacarbazine_Interferon-Alfa_Tamoxifen	Chemotherapy_Regimen	Cisplatin/Dacarbazine/Interferon Alfa/Tamoxifen|CDDP/DTIC/IFN-A/TMX
C11063	Ifosfamide_Interferon-Alfa_Pentostatin	Chemotherapy_Regimen	Ifosfamide/Interferon Alfa/Pentostatin|DCF/IFF/IFN-A
C11064	Fluorouracil_Interferon-Alfa_Leucovorin-Calcium_Sargramostim	Chemotherapy_Regimen	Fluorouracil/Interferon Alfa/Leucovorin Calcium/Sargramostim|CF/5-FU/IFN-A/GM-CSF
C11065	Carmustine_Cyclophosphamide_Etoposide_Interferon-Alfa	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Etoposide/Interferon Alfa|BCNU/CTX/IFN-A/VP-16
C11066	Bleomycin_Cyclophosphamide_Cytarabine_Doxorubicin_Etoposide_filgrastim_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Cytarabine/Doxorubicin/Etoposide/Filgrastim/Methotrexate/Prednisone/Vincristine|ARA-C/BLEO/CTX/DOX/G-CSF/MTX/PRED/VCR/VP-16
C11067	Dexamethasone_Interferon-Alfa	Chemotherapy_Regimen	Dexamethasone/Interferon Alfa|DM/IFN-A
C11068	Cisplatin_Dacarbazine_Interferon-Alfa_Interleukin-2_Vinblastine	Chemotherapy_Regimen	Cisplatin/Dacarbazine/Interferon Alfa/interleukin-2/Vinblastine|CDDP/DTIC/IFN-A/IL-2/VBL
C11069	Homoharringtonine_Interferon-Alfa	Chemotherapy_Regimen	Homoharringtonine/Interferon Alfa|HH/IFN-A
C11070	Filgrastim_Fluorouracil_Hydroxyurea_Interferon-Alfa	Chemotherapy_Regimen	Filgrastim/Fluorouracil/Hydroxyurea/Interferon Alfa|5-FU/G-CSF/HU/IFN-A
C11071	Cisplatin_Dacarbazine_Interferon-Alfa_Interleukin-2_Tamoxifen_Tumor-Infiltrating-Lymphocytes	Chemotherapy_Regimen	Cisplatin/Dacarbazine/Interferon Alfa/Interleukin-2/Tamoxifen/Tumor Infiltrating Lymphocytes|CDDP/DTIC/IFN-A/IL-2/TIL/TMX
C11072	Epoetin-Alfa_Interleukin-6_Sargramostim	Chemotherapy_Regimen	Epoetin Alfa/Interleukin-6/Sargramostim|EPO/GM-CSF/IL-6
C11073	Interferon-Alfa_Interleukin-2_Tamoxifen	Chemotherapy_Regimen	Interferon Alfa/Interleukin-2/Tamoxifen|IFN-A/IL-2/TMX
C11074	Fluorouracil_Interferon-Alfa_Leucovorin-Calcium_Raltitrexed	Chemotherapy_Regimen	Fluorouracil/Interferon Alfa/Leucovorin Calcium/Raltitrexed|CF/5-FU/ICI D1694/IFN-A
C11075	Carmustine_Cisplatin_Dacarbazine_Interferon-Alfa_Interleukin-2_Tamoxifen	Chemotherapy_Regimen	Carmustine/Cisplatin/Dacarbazine/Interferon Alfa/interleukin-2/Tamoxifen|BCNU/CDDP/DTIC/IFN-A/IL-2/TMX
C11076	Etoposide_Fluorouracil_Interferon-Alfa_Leucovorin-Calcium	Chemotherapy_Regimen	Etoposide/Fluorouracil/Interferon Alfa/Leucovorin Calcium|CF/5-FU/IFN-A/VP-16
C11077	Interferon-Alfa_Interleukin-2_Isotretinoin	Chemotherapy_Regimen	Interferon Alfa/Interleukin-2/Isotretinoin|13-CRA/IFN-A/IL-2
C11078	Fluorouracil_Interferon-Alfa_Interleukin-2_Isotretinoin	Chemotherapy_Regimen	Fluorouracil/Interferon Alfa/Interleukin-2/Isotretinoin|13-CRA/5-FU/IFN-A/IL-2
C11079	Cyclophosphamide_Interleukin-2_Monoclonal-Antibody-OKT3_Tumor-Necrosis-Factor	Chemotherapy_Regimen	Cyclophosphamide/Interleukin-2/Monoclonal Antibody OKT3/Tumor Necrosis Factor|CTX/IL-2/MOAB OKT3/TNF
C11080	Cyclophosphamide_Interleukin-2_Monoclonal-Antibody-OKT3	Chemotherapy_Regimen	Cyclophosphamide/Interleukin-2/Monoclonal Antibody OKT3|CTX/IL-2/MOAB OKT3
C11081	Bleomycin_Dacarbazine_Lomustine_Vincristine	Chemotherapy_Regimen	Bleomycin/Dacarbazine/Lomustine/Vincristine|BLEO/CCNU/DTIC/VCR
C11082	Bleomycin_Dacarbazine_Interferon-Alfa_Lomustine_Vincristine	Chemotherapy_Regimen	Bleomycin/Dacarbazine/Interferon Alfa/Lomustine/Vincristine|BLEO/CCNU/DTIC/IFN-A/VCR
C11083	Interleukin-2_Zinc-Oxide	Chemotherapy_Regimen	Interleukin-2/Zinc Oxide|IL-2/ZnO
C11084	Cisplatin_Dacarbazine_Interferon-Alfa_Interleukin-2	Chemotherapy_Regimen	Cisplatin/Dacarbazine/Interferon Alfa/interleukin-2|CDDP/DTIC/IFN-A/IL-2
C11085	Cisplatin_Dacarbazine_Interferon-Alfa	Chemotherapy_Regimen	Cisplatin/Dacarbazine/Interferon Alfa|CDDP/DTIC/IFN-A
C11086	Cyclophosphamide_Cytarabine_Thioguanine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Thioguanine/Vincristine|ARA-C/CTX/TG/VCR
C11087	Cyclophosphamide_Daunorubicin_Pegaspargase_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Daunorubicin/Pegaspargase/Prednisone/Vincristine|CTX/DNR/PEG-ASP/PRED/VCR
C11088	Cyclophosphamide_Cytarabine_Mercaptopurine_Pegaspargase_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Mercaptopurine/Pegaspargase/Vincristine|ARA-C/CTX/MP/PEG-ASP/VCR
C11089	Etoposide_Mitoxantrone_Tretinoin-Liposome	Chemotherapy_Regimen	Etoposide/Mitoxantrone/Tretinoin Liposome|DHAD/L-ATRA/VP-16
C11090	Cytarabine_Tretinoin-Liposome	Chemotherapy_Regimen	Cytarabine/Tretinoin Liposome|ARA-C/L-ATRA
C11091	Ketoconazole_Tretinoin	Chemotherapy_Regimen	Ketoconazole/Tretinoin|ATRA/KCZ
C11092	Disulfiram_Tretinoin	Chemotherapy_Regimen	Disulfiram/Tretinoin|ATRA/DS
C11093	Carmustine_Cytarabine_Methotrexate_Vincristine	Chemotherapy_Regimen	Carmustine/Cytarabine/Methotrexate/Vincristine|ARA-C/BCNU/MTX/VCR
C11094	Human-Chorionic-Gonadotropin_Staphage-Lysate	Chemotherapy_Regimen	Human Chorionic Gonadotropin/Staphage Lysate|HCG/SPL
C11095	Cisplatin_Fluorouracil_L-Leucovorin	Chemotherapy_Regimen	Cisplatin/Fluorouracil/L-Leucovorin|CDDP/5-FU/L-CF
C11096	Dexamethasone_Melphalan	Chemotherapy_Regimen	Dexamethasone/Melphalan|DM/L-PAM
C11097	Cyclophosphamide_Filgrastim_Paclitaxel	Chemotherapy_Regimen	Cyclophosphamide/Filgrastim/Paclitaxel|CTX/G-CSF/TAX
C11098	Cyclophosphamide_Paclitaxel_Sargramostim	Chemotherapy_Regimen	Cyclophosphamide/Paclitaxel/Sargramostim|CTX/GM-CSF/TAX
C11099	Busulfan_Dexamethasone_Thiotepa	Chemotherapy_Regimen	Busulfan/Dexamethasone/Thiotepa|BU/DM/TSPA
C11100	Cyclosporine_Methylprednisolone	Chemotherapy_Regimen	Cyclosporine/Methylprednisolone|CYSP/MePRDL
C11101	Dexamethasone_Doxorubicin_Pegaspargase_Vincristine	Chemotherapy_Regimen	Dexamethasone/Doxorubicin/Pegaspargase/Vincristine|DM/DOX/PEG-ASP/VCR
C11102	Dexamethasone_Pegaspargase_Vincristine	Chemotherapy_Regimen	Dexamethasone/Pegaspargase/Vincristine|DM/PEG-ASP/VCR
C11103	Carmustine_Cytarabine_Etoposide_Melphalan	Chemotherapy_Regimen	Carmustine/Cytarabine/Etoposide/Melphalan|ARA-C/BCNU/L-PAM/VP-16|BEAM
C11104	Idarubicin_Tretinoin-Liposome	Chemotherapy_Regimen	Idarubicin/Tretinoin Liposome|IDA/L-ATRA
C11105	Docetaxel_Vinorelbine	Chemotherapy_Regimen	Docetaxel/Vinorelbine|TXT/VNB
C11106	Docetaxel_Filgrastim_Vinorelbine	Chemotherapy_Regimen	Docetaxel/Filgrastim/Vinorelbine|G-CSF/TXT/VNB
C11107	Floxuridine_Gemcitabine_Leucovorin-Calcium	Chemotherapy_Regimen	Floxuridine/Gemcitabine/Leucovorin Calcium|CF/dFdC/FUDR
C11108	Filgrastim_Losoxantrone_Paclitaxel	Chemotherapy_Regimen	Filgrastim/Losoxantrone/Paclitaxel|DuP-941/G-CSF/TAX
C11109	Cyclophosphamide_Daunorubicin_Dexamethasone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Daunorubicin/Dexamethasone/Vincristine|CTX/DM/DNR/VCR
C11110	Cytarabine_Idarubicin_Thioguanine	Chemotherapy_Regimen	Cytarabine/Idarubicin/Thioguanine|ARA-C/IDA/TG
C11111	Interferon-Alfa_Interleukin-2_Paclitaxel	Chemotherapy_Regimen	Interferon Alfa/Interleukin-2/Paclitaxel|IFN-A/IL-2/TAX
C11112	Mercaptopurine_Methotrexate_Tretinoin	Chemotherapy_Regimen	Mercaptopurine/Methotrexate/Tretinoin|ATRA/MP/MTX
C11113	Carboplatin_Cisplatin_Interferon-Alfa_Interleukin-2_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Cisplatin/Interferon Alfa/interleukin-2/Paclitaxel|CBDCA/CDDP/IFN-A/IL-2/TAX
C11114	Interleukin-2_Melatonin	Chemotherapy_Regimen	Interleukin-2/Melatonin|IL-2/MLT
C11115	Paclitaxel_Vinorelbine	Chemotherapy_Regimen	Paclitaxel/Vinorelbine|TAX/VNB
C11116	Asparaginase_Cyclophosphamide_Cytarabine_Etoposide_Mercaptopurine_Methotrexate	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Etoposide/Mercaptopurine/Methotrexate|ARA-C/ASP/CTX/MP/MTX/VP-16
C11117	Cisplatin_gemcitabine	Chemotherapy_Regimen	Cisplatin/Gemcitabine|CDDP/dFdC
C11118	Carboplatin_RMP-7	Chemotherapy_Regimen	Carboplatin/RMP-7|CBDCA/RMP-7
C11119	Epirubicin_Vinorelbine	Chemotherapy_Regimen	Epirubicin/Vinorelbine|EPI/VNB
C11120	Allovectin-7_Interleukin-2	Chemotherapy_Regimen	Allovectin-7/Interleukin-2|allovectin-7/IL-2
C11121	Cyclophosphamide_Losoxantrone	Chemotherapy_Regimen	Cyclophosphamide/Losoxantrone|CTX/DuP-941
C11122	Doxorubicin_Losoxantrone	Chemotherapy_Regimen	Doxorubicin/Losoxantrone|DOX/DuP-941
C11123	Cyclophosphamide_Daunorubicin	Chemotherapy_Regimen	Cyclophosphamide/Daunorubicin|CTX/DNR|Cyclophosphamide/Daunomycin
C11124	Asparaginase_Cytarabine_Methotrexate	Chemotherapy_Regimen	Asparaginase/Cytarabine/Methotrexate|ARA-C/ASP/MTX
C11125	Daunorubicin_Dexamethasone	Chemotherapy_Regimen	Daunorubicin/Dexamethasone|DM/DNR
C11126	Fluorouracil_Octreotide-Pamoate	Chemotherapy_Regimen	Fluorouracil/Octreotide Pamoate|5-FU/SMS 201-995 pa
C11127	_9-cis-Retinoic-Acid_Tamoxifen	Chemotherapy_Regimen	9-cis-Retinoic Acid/Tamoxifen|9-CRA/TMX
C11128	Dexrazoxane_Doxorubicin_Paclitaxel	Chemotherapy_Regimen	Dexrazoxane/Doxorubicin/Paclitaxel|ADR-529/DOX/TAX
C11129	Dexrazoxane_Doxorubicin_Filgrastim_Paclitaxel	Chemotherapy_Regimen	Dexrazoxane/Doxorubicin/Filgrastim/Paclitaxel|ADR-529/DOX/G-CSF/TAX
C11130	Amsacrine_Carmustine_Cytarabine_Etoposide	Chemotherapy_Regimen	Amsacrine/Carmustine/Cytarabine/Etoposide|AMSA/ARA-C/BCNU/VP-16
C11131	Cyclophosphamide_Etoposide_Mitoxantrone	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Mitoxantrone|CTX/DHAD/VP-16
C11132	Fluorouracil_Leucovorin-Calcium_Topotecan	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Topotecan|CF/5-FU/TOPO
C11133	Carmustine_Etoposide	Chemotherapy_Regimen	Carmustine/Etoposide|BCNU/VP-16
C11134	Letrozole_Tamoxifen	Chemotherapy_Regimen	Letrozole/Tamoxifen|letrozole/TMX
C11135	Cyclosporine_Prednisone	Chemotherapy_Regimen	Cyclosporine/Prednisone|CYSP/PRED
C11136	Doxorubicin_Estramustine	Chemotherapy_Regimen	Doxorubicin/Estramustine|DOX/EM
C11137	Etoposide_Ifosfamide_Mesna_Mitoxantrone	Chemotherapy_Regimen	Etoposide/Ifosfamide/Mesna/Mitoxantrone|DHAD/IFF/mesna/VP-16|MINE
C11138	Interferon-Gamma_Monoclonal-Antibody-CC49	Chemotherapy_Regimen	Interferon Gamma/Monoclonal Antibody CC49|IFN-G/MOAB CC49
C11139	Cyclosporine_Cytarabine_Daunorubicin_Etoposide	Chemotherapy_Regimen	Cyclosporine/Cytarabine/Daunorubicin/Etoposide|ARA-C/CYSP/DNR/VP-16
C11140	Cyclosporine_Cytarabine_Etoposide_Idarubicin	Chemotherapy_Regimen	Cyclosporine/Cytarabine/Etoposide/Idarubicin|ARA-C/CYSP/IDA/VP-16
C11141	Asparaginase_Dexrazoxane_Doxorubicin_Mercaptopurine_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Dexrazoxane/Doxorubicin/Mercaptopurine/Prednisone/Vincristine|ADR-529/ASP/DOX/MP/PRED/VCR
C11142	Asparaginase_Dexrazoxane_Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/dexrazoxane/Doxorubicin/Mercaptopurine/Methotrexate/Prednisone/Vincristine|ADR-529/ASP/DOX/MP/MTX/PRED/VCR
C11143	Asparaginase_Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Doxorubicin/Mercaptopurine/Methotrexate/Prednisone/Vincristine|ASP/DOX/MP/MTX/PRED/VCR
C11144	Dexrazoxane_Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Dexrazoxane/Doxorubicin/Mercaptopurine/Methotrexate/Prednisone/Vincristine|ADR-529/DOX/MP/MTX/PRED/VCR
C11145	Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Pegaspargase_Thioguanine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Pegaspargase/Thioguanine/Vincristine|ARA-C/CTX/DM/DOX/PEG-ASP/TG/VCR
C11146	Methotrexate_Pegaspargase_Vincristine	Chemotherapy_Regimen	Methotrexate/Pegaspargase/Vincristine|MTX/PEG-ASP/VCR|capi33i I
C11147	Mercaptopurine_Vincristine	Chemotherapy_Regimen	Mercaptopurine/Vincristine|MP/VCR
C11148	Estramustine_Strontium-Chloride-Sr-89_Vinblastine	Chemotherapy_Regimen	Estramustine/Strontium Chloride Sr 89/Vinblastine|EM/Strontium Chloride Sr 89/VBL
C11149	AG337_Cisplatin	Chemotherapy_Regimen	AG337/Cisplatin|AG337/CDDP
C11150	Cyclophosphamide_Cytarabine_Daunorubicin_Dexamethasone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Daunorubicin/Dexamethasone/Vincristine|ARA-C/CTX/DM/DNR/VCR
C11151	Cyclophosphamide_Cytarabine_Methylprednisolone	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Methylprednisolone|ARA-C/CTX/MePRDL
C11152	Hydrocortisone_Methotrexate	Chemotherapy_Regimen	Hydrocortisone/Methotrexate|HC/MTX
C11153	Asparaginase_Dexamethasone_Epirubicin_Vincristine	Chemotherapy_Regimen	Asparaginase/Dexamethasone/Epirubicin/Vincristine|ASP/DM/EPI/VCR
C11154	Cytarabine_Etoposide_Vincristine	Chemotherapy_Regimen	Cytarabine/Etoposide/Vincristine|ARA-C/VCR/VP-16
C11155	Cytarabine_Etoposide_Thioguanine_Vincristine	Chemotherapy_Regimen	Cytarabine/Etoposide/Thioguanine/Vincristine|ARA-C/CTX/TG/VP-16
C11156	Asparaginase_Cyclophosphamide_Cytarabine_Dexamethasone_Epirubicin_Etoposide_Thioguanine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Dexamethasone/Epirubicin/Etoposide/Thioguanine/Vincristine|ARA-C/ASP/CTX/DM/EPI/TG/VCR/VP-16
C11157	Cyclophosphamide_Cytarabine_Etoposide_Mercaptopurine_Methotrexate_Prednisolone_Thioguanine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Etoposide/Mercaptopurine/Methotrexate/Prednisolone/Thioguanine/Vincristine|ARA-C/CTX/MP/MTX/PRDL/TG/VCR/VP-16
C11158	Carboplatin_Filgrastim	Chemotherapy_Regimen	Carboplatin/Filgrastim|CBDCA/G-CSF
C11159	Cimetidine_Tumor-Infiltrating-Lymphocytes	Chemotherapy_Regimen	Cimetidine/Tumor Infiltrating Lymphocytes|cimetidine/TIL
C11160	Asparaginase_Cyclophosphamide_Daunorubicin_Dexamethasone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Daunorubicin/Dexamethasone/Vincristine|ASP/CTX/DM/DNR/VCR
C11161	GM2-KLH-Vaccine_Interferon-Alfa	Chemotherapy_Regimen	GM2-KLH Vaccine/Interferon Alfa|GM2-KLH/IFN-A
C11162	Cisplatin_Fluorouracil_Tirapazamine	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Tirapazamine|CDDP/5-FU/SR-4233
C11163	Cytarabine_Etoposide_Methotrexate_Pegaspargase_Prednisone_Thioguanine_Vincristine	Chemotherapy_Regimen	Cytarabine/Etoposide/Methotrexate/Pegaspargase/Prednisone/Thioguanine/Vincristine|ARA-C/MTX/PEG-ASP/PRED/TG/VCR/VP-16
C11164	Asparaginase_Prednisolone_Vincristine	Chemotherapy_Regimen	Asparaginase/Prednisolone/Vincristine|ASP/PRDL/VCR
C11165	Mercaptopurine_Prednisolone_Vincristine	Chemotherapy_Regimen	Mercaptopurine/Prednisolone/Vincristine|MP/PRDL/VCR
C11166	Fludarabine_Octreotide	Chemotherapy_Regimen	Fludarabine/Octreotide|FAMP/SSTN
C11167	Cytarabine_Hydroxyurea_Interferon-Alfa	Chemotherapy_Regimen	Cytarabine/Hydroxyurea/Interferon Alfa|ARA-C/HU/IFN-A
C11168	BCG_Dacarbazine	Chemotherapy_Regimen	BCG/Dacarbazine|BCG/DTIC
C11169	Amifostine_Paclitaxel	Chemotherapy_Regimen	Amifostine/Paclitaxel|TAX/WR-2721
C11170	Cisplatin_Isotretinoin	Chemotherapy_Regimen	Cisplatin/Isotretinoin|CDDP/13-CRA
C11171	Cyclophosphamide_Cyclosporine_Cytarabine_Daunorubicin	Chemotherapy_Regimen	Cyclophosphamide/Cyclosporine/Cytarabine/Daunorubicin|ARA-C/CTX/CYSP/DNR
C11172	Cyclophosphamide_Etoposide_Mitoxantrone_Pegaspargase_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Mitoxantrone/Pegaspargase/Prednisone/Vincristine|CTX/DHAD/PEG-ASP/PRED/VCR/VP-16
C11173	Suramin_Topotecan	Chemotherapy_Regimen	Suramin/Topotecan|SUR/TOPO
C11174	Doxorubicin_VX-710	Chemotherapy_Regimen	Doxorubicin/VX-710|DOX/VX-710
C11175	Cyclosporine_Interferon-Gamma_Interleukin-2	Chemotherapy_Regimen	Cyclosporine/Interferon Gamma/Interleukin-2|CYSP/IFN-G/IL-2
C11176	Carmustine_Interferon-Alfa_Tamoxifen	Chemotherapy_Regimen	Carmustine/Interferon Alfa/Tamoxifen|BCNU/IFN-A/TMX
C11177	Bleomycin_Carboplatin_Cisplatin_Vincristine	Chemotherapy_Regimen	Bleomycin/Carboplatin/Cisplatin/Vincristine|BLEO/CBDCA/CDDP/VCR
C11178	Cyclophosphamide_Dexamethasone_Etoposide_Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Etoposide/Mercaptopurine/Methotrexate/Vincristine|CTX/DM/MP/MTX/VCR/VP-16
C11179	Dacarbazine_Doxorubicin_Ifosfamide_Mesna	Chemotherapy_Regimen	Dacarbazine/Doxorubicin/Ifosfamide/Mesna|DOX/DTIC/IFF/mesna|MAID
C11180	Cyclosporine_Methylprednisolone_Prednisone	Chemotherapy_Regimen	Cyclosporine/Methylprednisolone/Prednisone|CYSP/MePRDL/PRED
C11181	Cyclophosphamide_Cytarabine_Daunorubicin	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Daunorubicin|ARA-C/CTX/DNR
C11182	Cisplatin_Interleukin-2_Paclitaxel_Tumor-Infiltrating-Lymphocytes	Chemotherapy_Regimen	Cisplatin/interleukin-2/Paclitaxel/Tumor Infiltrating Lymphocytes|CDDP/IL-2/TAX/TIL
C11183	Carboplatin_Paclitaxel_Topotecan	Chemotherapy_Regimen	Carboplatin/Paclitaxel/Topotecan|CBDCA/TAX/TOPO
C11184	Carboplatin_Filgrastim_Paclitaxel_Topotecan	Chemotherapy_Regimen	Carboplatin/filgrastim/Paclitaxel/Topotecan|CBDCA/G-CSF/TAX/TOPO
C11185	P-30-protein_Tamoxifen	Chemotherapy_Regimen	P-30 Protein/Tamoxifen|Onconase/TAM|Onconase/TMX|Onconase/Tamoxifen|P-30 Protein/TAM|P-30 Protein/TMX|Ranpirnase/Tamoxifen
C11186	Cladribine_Etoposide	Chemotherapy_Regimen	Cladribine/Etoposide|2-CdA/VP-16
C11187	Prednisone_Tacrolimus	Chemotherapy_Regimen	Prednisone/Tacrolimus|FK506/PRED
C11188	Fluorouracil_Phenylbutyrate	Chemotherapy_Regimen	Fluorouracil/Phenylbutyrate|5-FU/PBA
C11189	Etoposide_Methylprednisolone	Chemotherapy_Regimen	Etoposide/Methylprednisolone|MePRDL/VP-16
C11190	Melphalan_Mitoxantrone	Chemotherapy_Regimen	Melphalan/Mitoxantrone|DHAD/L-PAM
C11191	Carboplatin_Etoposide_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Etoposide/Paclitaxel|CBDCA/TAX/VP-16
C11192	Carboplatin_Cyclosporine_Doxorubicin	Chemotherapy_Regimen	Carboplatin/Cyclosporine/Doxorubicin|CBDCA/CYSP/DOX
C11193	Cytarabine_Deoxycytidine	Chemotherapy_Regimen	Cytarabine/Deoxycytidine|ARA-C/dC
C11194	Octreotide-Pamoate_Tamoxifen	Chemotherapy_Regimen	Octreotide Pamoate/Tamoxifen|SMS 201-995 pa/TMX
C11195	Carboplatin_9-cis-Retinoic-Acid	Chemotherapy_Regimen	Carboplatin/9-cis-Retinoic Acid|CBDCA/9-CRA
C11196	Bleomycin_Dexrazoxane_Doxorubicin_Etoposide_Vincristine	Chemotherapy_Regimen	Bleomycin/Dexrazoxane/Doxorubicin/Etoposide/Vincristine|ADR-529/BLEO/DOX/VCR/VP-16
C11197	Fluorouracil_Leucovorin-Calcium_Oxaliplatin	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Oxaliplatin|CF/5-FU/L-OHP|FOLFOX
C11198	Fluorouracil_Gemcitabine	Chemotherapy_Regimen	Fluorouracil/Gemcitabine|dFdC/5-FU
C11199	Carboplatin_Cyclosporine_Dipyridamole_Etoposide_Prochlorperazine	Chemotherapy_Regimen	Carboplatin/Cyclosporine/Dipyridamole/Etoposide/Prochlorperazine|CBDCA/CYSP/DP/PCPZ/VP-16
C11200	Carboplatin_Cyclosporine_Interferon-Alfa	Chemotherapy_Regimen	Carboplatin/Cyclosporine/Interferon Alfa|CBDCA/CYSP/IFN-A
C11201	Cisplatin_Toremifene	Chemotherapy_Regimen	Cisplatin/Toremifene|CDDP/TOR
C11202	Dexamethasone_Etoposide_Ifosfamide_Pegaspargase_Vincristine	Chemotherapy_Regimen	Dexamethasone/Etoposide/Ifosfamide/Pegaspargase/Vincristine|DM/IFF/PEG-ASP/VCR/VP-16
C11203	Dexamethasone_Methotrexate_Pegaspargase_Vincristine	Chemotherapy_Regimen	Dexamethasone/Methotrexate/Pegaspargase/Vincristine|DM/MTX/PEG-ASP/VCR
C11204	Cyclophosphamide_Dexamethasone_Idarubicin_Pegaspargase_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Idarubicin/Pegaspargase/Vincristine|CTX/DM/IDA/PEG-ASP/VCR
C11205	Cytarabine_Pegaspargase_Thioguanine_Vincristine	Chemotherapy_Regimen	Cytarabine/Pegaspargase/Thioguanine/Vincristine|ARA-C/PEG-ASP/TG/VCR
C11206	Pegaspargase_Vincristine	Chemotherapy_Regimen	Pegaspargase/Vincristine|PEG-ASP/VCR
C11207	Carboplatin_Ifosfamide_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Ifosfamide/Paclitaxel|CBDCA/IFF/TAX
C11208	Carboplatin_Cyclophosphamide_Cyclosporine_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Cyclosporine/Paclitaxel|CBDCA/CTX/CYSP/TAX
C11209	Cisplatin_Cyclophosphamide_Cyclosporine_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Cyclosporine/Paclitaxel|CDDP/CTX/CYSP/TAX
C11210	Docetaxel_Epirubicin	Chemotherapy_Regimen	Docetaxel/Epirubicin|EPI/TXT
C11211	Docetaxel_Epirubicin_Filgrastim	Chemotherapy_Regimen	Docetaxel/Epirubicin/Filgrastim|EPI/G-CSF/TXT
C11212	Dronabinol_Megestrol	Chemotherapy_Regimen	Dronabinol/Megestrol|MEG/THC
C11213	Cisplatin_Doxorubicin_Edatrexate_Filgrastim_Vinblastine	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Edatrexate/Filgrastim/Vinblastine|CDDP/DOX/EDAM/G-CSF/VBL
C11214	Doxorubicin_PSC-833	Chemotherapy_Regimen	Doxorubicin/PSC 833|DOX/PSC 833
C11215	Cyclophosphamide_Melphalan_Mitoxantrone	Chemotherapy_Regimen	Cyclophosphamide/Melphalan/Mitoxantrone|CTX/DHAD/L-PAM
C11216	Aminoglutethimide_Bicalutamide_Hydrocortisone	Chemotherapy_Regimen	Aminoglutethimide/Bicalutamide/Hydrocortisone|AGT/CDX/HC
C11217	Aminoglutethimide_Hydrocortisone	Chemotherapy_Regimen	Aminoglutethimide/Hydrocortisone|AGT/HC
C11218	Docetaxel_Doxorubicin	Chemotherapy_Regimen	Docetaxel/Doxorubicin|DOX/TXT
C11219	Cisplatin_Doxorubicin_Ifosfamide_Mitomycin	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Ifosfamide/Mitomycin|CDDP/DOX/IFF/MITO
C11220	Cisplatin_Doxorubicin_Ifosfamide_Mitomycin_sargramostim	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Ifosfamide/Mitomycin/Sargramostim|CDDP/DOX/GM-CSF/IFF/MITO
C11221	Doxorubicin_DPPE	Chemotherapy_Regimen	Doxorubicin/DPPE|DOX/DPPE
C11222	Dacarbazine_Doxorubicin_Ifosfamide_Vincristine	Chemotherapy_Regimen	Dacarbazine/Doxorubicin/Ifosfamide/Vincristine|DOX/DTIC/IFF/VCR
C11223	Dexamethasone_Doxorubicin_PSC-833_Vincristine	Chemotherapy_Regimen	Dexamethasone/Doxorubicin/PSC 833/Vincristine|DM/DOX/PSC 833/VCR
C11224	Cyclosporine_Methotrexate_Sirolimus	Chemotherapy_Regimen	Cyclosporine/Methotrexate/Sirolimus|CYSP/MTX/sirolimus
C11225	Interferon-Gamma_Interleukin-1-Beta_Interleukin-2_Sargramostim_Tumor-Necrosis-Factor	Chemotherapy_Regimen	Interferon Gamma/Interleukin-1-Beta/Interleukin-2/Sargramostim/Tumor Necrosis Factor|GM-CSF/IFN-G/IL-1B/IL-2/TNF
C11226	Cyclophosphamide_Indomethacin_Zinc-Sulfate	Chemotherapy_Regimen	Cyclophosphamide/Indomethacin/Zinc Sulfate|CTX/indomethacin/zinc sulfate
C11227	Cisplatin_Hydroxyurea_Vinblastine	Chemotherapy_Regimen	Cisplatin/Hydroxyurea/Vinblastine|CDDP/HU/VBL
C11228	Cisplatin_Etoposide_Hydroxyurea	Chemotherapy_Regimen	Cisplatin/Etoposide/Hydroxyurea|CDDP/HU/VP-16
C11229	Cisplatin_Hydroxyurea_vinorelbine	Chemotherapy_Regimen	Cisplatin/Hydroxyurea/Vinorelbine|CDDP/HU/VNB
C11230	Cisplatin_Hydroxyurea_Vindesine	Chemotherapy_Regimen	Cisplatin/Hydroxyurea/Vindesine|CDDP/DAVA/HU
C11231	Cisplatin_Hydroxyurea	Chemotherapy_Regimen	Cisplatin/Hydroxyurea|CDDP/HU
C11232	Carboplatin_Epirubicin_Vincristine	Chemotherapy_Regimen	Carboplatin/Epirubicin/Vincristine|CBDCA/EPI/VCR
C11233	gp100-Antigen_MART-1-Antigen	Chemotherapy_Regimen	gp100 Antigen/MART-1 Antigen|gp100/MART-1
C11234	Bryostatin-1_Vincristine	Chemotherapy_Regimen	Bryostatin 1/Vincristine|BRYO/VCR
C11235	Doxorubicin_Progesterone	Chemotherapy_Regimen	Doxorubicin/Progesterone|DOX/progesterone
C11236	Cyclophosphamide_Doxorubicin_Filgrastim_Paclitaxel	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Filgrastim/Paclitaxel|CTX/DOX/G-CSF/TAX
C11237	Irinotecan_Raltitrexed	Chemotherapy_Regimen	Irinotecan/Raltitrexed|CPT-11/ICI D1694
C11238	Cisplatin_filgrastim_Paclitaxel_topotecan	Chemotherapy_Regimen	Cisplatin/Filgrastim/Paclitaxel/Topotecan|CDDP/G-CSF/TAX/TOPO
C11239	Cisplatin_Paclitaxel_Topotecan	Chemotherapy_Regimen	Cisplatin/Paclitaxel/Topotecan|CDDP/TAX/TOPO
C11240	Chlorodihydroxypyridine_Potassium-Oxonate_Tegafur	Chemotherapy_Regimen	Chlorodihydroxypyridine/Potassium Oxonate/Tegafur|CDHP/FT/Oxo
C11241	Bleomycin_Cyclophosphamide_Idarubicin_Methylprednisolone_Methotrexate_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Idarubicin/Methylprednisolone/Methotrexate/Vincristine|BLEO/CTX/IDA/MEPRDL/MTX/VCR
C11242	Methotrexate_Tacrolimus	Chemotherapy_Regimen	Methotrexate/Tacrolimus|FK506/MTX
C11243	Indinavir_Lamivudine_Stavudine	Chemotherapy_Regimen	Indinavir/Lamivudine/Stavudine|3TC/d4T/IDV
C11244	Cyclophosphamide_Doxorubicin_Prednisone_Sargramostim_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Prednisone/Sargramostim/Vincristine|CTX/DOX/GM-CSF/PRED/VCR
C11245	Carboplatin_Cyclophosphamide_Etoposide_filgrastim_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Etoposide/Filgrastim/Paclitaxel|CBDCA/CTX/G-CSF/TAX/VP-16
C11246	Cyclophosphamide_Epirubicin_Filgrastim_Fluorouracil	Chemotherapy_Regimen	Cyclophosphamide/Epirubicin/Filgrastim/Fluorouracil|CTX/EPI/5-FU/G-CSF
C11247	Irinotecan_Paclitaxel	Chemotherapy_Regimen	Irinotecan/Paclitaxel|CPT-11/TAX
C11248	Cisplatin_Mitomycin_Vincristine	Chemotherapy_Regimen	Cisplatin/Mitomycin/Vincristine|CDDP/MITO/VCR
C11249	Lomustine_Procarbazine_Thioguanine_Vincristine	Chemotherapy_Regimen	Lomustine/Procarbazine/Thioguanine/Vincristine|CCNU/PCB/TG/VCR
C11250	Cyclophosphamide_Doxorubicin_Prednisone_Rituximab_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Prednisone/Rituximab/Vincristine|CTX/DOX/MOAB IDEC-C2B8/PRED/VCR|Rituxan/CHOP|rituximab/cyclophosphamide/doxorubicin/prednisone/vincristine
C11251	Carmustine_Cyclophosphamide_Etoposide_Mesna	Chemotherapy_Regimen	Carmustine/Cyclophosphamide/Etoposide/Mesna|BCNU/CTX/Mesna/VP-16
C11252	Ethynyluracil_Fluorouracil	Chemotherapy_Regimen	Ethynyluracil/Fluorouracil|776C85/5-FU
C11253	Ethynyluracil_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Ethynyluracil/Fluorouracil/Leucovorin Calcium|776C85/CF/5-FU
C11254	Epirubicin_Paclitaxel	Chemotherapy_Regimen	Epirubicin/Paclitaxel|EPI/TAX
C11255	Dexamethasone_Fludarabine_Mitoxantrone	Chemotherapy_Regimen	Dexamethasone/Fludarabine/Mitoxantrone|DHAD/DM/FAMP
C11256	Paclitaxel_VX-710	Chemotherapy_Regimen	Paclitaxel/VX-710|TAX/VX-710
C11257	Docetaxel_Estramustine_Hydrocortisone	Chemotherapy_Regimen	Docetaxel/Estramustine/Hydrocortisone|EM/HC/TXT
C11258	Busulfan_Cyclophosphamide_Decitabine	Chemotherapy_Regimen	Busulfan/Cyclophosphamide/Decitabine|BU/CTX/DAC
C11259	Cladribine_Cytarabine	Chemotherapy_Regimen	Cladribine/Cytarabine|ARA-C/2-CdA
C11260	Cisplatin_Ifosfamide_Mesna_Mitomycin	Chemotherapy_Regimen	Cisplatin/Ifosfamide/Mesna/Mitomycin|CDDP/IFF/mesna/MITO|MIMIC
C11261	Anti-Thymocyte-Globulin_Melphalan	Chemotherapy_Regimen	Anti-thymocyte Globulin/Melphalan|ATG/L-PAM
C11262	Carmustine_Cisplatin_filgrastim_Thiotepa	Chemotherapy_Regimen	Carmustine/Cisplatin/Filgrastim/Thiotepa|BCNU/CTX/G-CSF/TSPA
C11263	Cyclophosphamide_Dexamethasone_Etoposide	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Etoposide|CTX/DM/VP-16
C11264	Fluorouracil_Marimastat	Chemotherapy_Regimen	Fluorouracil/Marimastat|BB-2516/5-FU
C11265	Cytarabine_Lomustine_Methotrexate_Methylprednisolone_Procarbazine	Chemotherapy_Regimen	Cytarabine/Lomustine/Methotrexate/Methylprednisolone/Procarbazine|ARA-C/CCNU/MePRDL/MTX/PCB
C11266	Etoposide_Ifosfamide_Mesna	Chemotherapy_Regimen	Etoposide/Ifosfamide/Mesna|IFF/Mesna/VP-16|Ifosfa/Mesna/Etop
C11267	Ifosfamide_Mesna_Mitoxantrone	Chemotherapy_Regimen	Ifosfamide/Mesna/Mitoxantrone|DHAD/IFF/mesna
C11268	Cyclophosphamide_Doxorubicin_Octreotide-Pamoate_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Octreotide Pamoate/Tamoxifen|CTX/DOX/SMS 201-995 pa/TMX
C11269	Cyclophosphamide_Filgrastim_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Filgrastim/Vincristine|CTX/G-CSF/VCR
C11270	Carboplatin_Ifosfamide_Mesna	Chemotherapy_Regimen	Carboplatin/Ifosfamide/Mesna|CBDCA/IFF/mesna|carboplatin/ifosfamide/mercaptoethane sulfonate
C11271	Carboplatin_Filgrastim_Ifosfamide_Mesna	Chemotherapy_Regimen	Carboplatin/filgrastim/Ifosfamide/Mesna|CBDCA/G-CSF/IFF/mesna|carboplatin/filgrastim/ifosfamide/mercaptoethane sulfonate
C11272	Cisplatin_Paclitaxel_Tirapazamine	Chemotherapy_Regimen	Cisplatin/Paclitaxel/Tirapazamine|CDDP/SR-4233/TAX
C11273	Carmustine_Topotecan	Chemotherapy_Regimen	Carmustine/Topotecan|BCNU/TOPO
C11274	Carmustine_Irinotecan	Chemotherapy_Regimen	Carmustine/Irinotecan|BCNU/CPT-11
C11275	Bleomycin_Cyclophosphamide_Doxorubicin_Etoposide_Prednisolone_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Doxorubicin/Etoposide/Prednisolone/Vincristine|BLEO/CTX/DOX/PRDL/VCR/VP-16
C11276	Interferon-Alfa_Ritonavir_Stavudine	Chemotherapy_Regimen	Interferon Alfa/Ritonavir/Stavudine|d4T/IFN-A/RIT
C11277	Cordycepin_Pentostatin	Chemotherapy_Regimen	Cordycepin/Pentostatin|COR/DCF
C11278	Flavopiridol_Paclitaxel	Chemotherapy_Regimen	Flavopiridol/Paclitaxel|FLAVO/TAX
C11279	Bleomycin_Doxorubicin_Vindesine	Chemotherapy_Regimen	Bleomycin/Doxorubicin/Vindesine|BLEO/DAVA/DOX
C11280	Fluorouracil-Uracil	Retired_Concepts	Fluorouracil-Uracil
C11281	Fluorouracil_Hydroxyurea_Paclitaxel	Chemotherapy_Regimen	Fluorouracil/Hydroxyurea/Paclitaxel|5-FU/HU/TAX
C11282	Epoetin-Alfa_Fluorouracil_Hydroxyurea_Paclitaxel	Chemotherapy_Regimen	Epoetin Alfa/Fluorouracil/Hydroxyurea/Paclitaxel|EPO/5-FU/HU/TAX
C11283	Cisplatin_Docetaxel_Gemcitabine	Chemotherapy_Regimen	Cisplatin/Docetaxel/Gemcitabine|CDDP/dFdC/TXT
C11284	Cytarabine_Etoposide_Mitoxantrone_PSC-833	Chemotherapy_Regimen	Cytarabine/Etoposide/Mitoxantrone/PSC 833|ARA-C/DHAD/PSC 833/VP-16
C11285	Carboplatin_Estramustine_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Estramustine/Paclitaxel|CBDCA/EM/TAX
C11286	Amifostine_Cisplatin_Paclitaxel	Chemotherapy_Regimen	Amifostine/Cisplatin/Paclitaxel|CDDP/TAX/WR-2721
C11287	Amifostine_Carboplatin_Paclitaxel	Chemotherapy_Regimen	Amifostine/Carboplatin/Paclitaxel|CBDCA/TAX/WR-2721
C11288	Amifostine_Topotecan	Chemotherapy_Regimen	Amifostine/Topotecan|TOPO/WR-2721
C11289	Marimastat_Tamoxifen	Chemotherapy_Regimen	Marimastat/Tamoxifen|BB-2516/TMX
C11290	Amifostine_Cisplatin_Fluorouracil	Chemotherapy_Regimen	Amifostine/Cisplatin/Fluorouracil|CDDP/5-FU/WR-2721
C11291	Doxorubicin-HCl-Liposome_VX-853	Chemotherapy_Regimen	Doxorubicin HCl Liposome/VX-853|LipoDox/VX-853
C11292	Cyclophosphamide_Doxorubicin_Marimastat	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Marimastat|BB-2516/CTX/DOX
C11293	Floxuridine_Leucovorin-Calcium_Melphalan	Chemotherapy_Regimen	Floxuridine/Leucovorin Calcium/Melphalan|CF/FUDR/L-PAM
C11294	Etoposide_Ifosfamide_Mesna_Topotecan	Chemotherapy_Regimen	Etoposide/Ifosfamide/Mesna/Topotecan|VP-16/IFF/Mesna/TOPO
C11295	Etoposide-Phosphate_Topotecan	Chemotherapy_Regimen	Etoposide Phosphate/Topotecan|ETOP/TOPO
C11296	Doxorubicin_Etoposide_Ifosfamide	Chemotherapy_Regimen	Doxorubicin/Etoposide/Ifosfamide|DOX/IFF/VP-16
C11297	Doxorubicin_Raltitrexed	Chemotherapy_Regimen	Doxorubicin/Raltitrexed|DOX/ICI D1694
C11298	Anti-Thymocyte-Globulin_Cyclophosphamide	Chemotherapy_Regimen	Anti-thymocyte Globulin/Cyclophosphamide|ATG/CTX
C11299	Estramustine_Etoposide_Paclitaxel	Chemotherapy_Regimen	Estramustine/Etoposide/Paclitaxel|EM/TAX/VP-16
C11300	Doxorubicin_Estramustine_Ketoconazole_Vinblastine	Chemotherapy_Regimen	Doxorubicin/Estramustine/Ketoconazole/Vinblastine|DOX/EM/KCZ/VBL
C11301	Amifostine_Ciprofloxacin_Pentoxifylline	Chemotherapy_Regimen	Amifostine/Ciprofloxacin/Pentoxifylline|CPFX/PTX/WR-2721
C11302	Amifostine_Ciprofloxacin_Dexamethasone_Pentoxifylline	Chemotherapy_Regimen	Amifostine/Ciprofloxacin/Dexamethasone/Pentoxifylline|CPFX/DM/PTX/WR-2721
C11303	Docetaxel_Estramustine	Chemotherapy_Regimen	Docetaxel/Estramustine|EM/TXT
C11304	Oltipraz_Vitamin-A	Chemotherapy_Regimen	Oltipraz/Vitamin A|OPZ/VIT-A
C11305	Fenretinide_Vitamin-A	Chemotherapy_Regimen	Fenretinide/Vitamin A|HPR/VIT-A
C11306	Calcium-Carbonate_Cholecalciferol	Chemotherapy_Regimen	Calcium Carbonate/Cholecalciferol|CACO3/VIT-D|Calcium Carbonate + Cholecalciferol
C11307	Bryostatin-1_Cytarabine	Chemotherapy_Regimen	Bryostatin 1/Cytarabine|ARA-C/BRYO
C11308	Amifostine_Cyclophosphamide_Mitoxantrone_Thiotepa	Chemotherapy_Regimen	Amifostine/Cyclophosphamide/Mitoxantrone/Thiotepa|CTX/DHAD/TSPA/WR-2721
C11309	Fluorouracil_Raltitrexed	Chemotherapy_Regimen	Fluorouracil/Raltitrexed|5-FU/ICI D1694
C11310	Bryostatin-1_Cisplatin	Chemotherapy_Regimen	Bryostatin 1/Cisplatin|BRYO/CDDP
C11311	Carboplatin_Cyclophosphamide_Doxorubicin	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Doxorubicin|CBDCA/CTX/DOX
C11312	Doxorubicin_Gemcitabine	Chemotherapy_Regimen	Doxorubicin/Gemcitabine|dFdC/DOX
C11313	Fluorouracil_Gemcitabine_Leucovorin-Calcium	Chemotherapy_Regimen	Fluorouracil/Gemcitabine/Leucovorin Calcium|5FU/Leucovorin/Gemcitabine|CF/dFdC/5-FU
C11314	Cyclophosphamide_Etoposide_Lomustine_Procarbazine	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Lomustine/Procarbazine|CCNU/CTX/PCB/VP-16
C11315	Bacitracin_Clotrimazole_Gentamicin	Chemotherapy_Regimen	Bacitracin/Clotrimazole/Gentamicin|BAC/CLOT/GM
C11316	AUT-OV-ALVAC-hB7-1_Interferon-Gamma	Chemotherapy_Regimen	AUT-OV-ALVAC-hB7.1/Interferon Gamma|ALVAC hB7.1/IFN-G|ALVAC-hB7.1/Interferon Gamma
C11317	Gemcitabine_Irinotecan	Chemotherapy_Regimen	Gemcitabine/Irinotecan|CPT-11/dFdC
C11318	Amifostine_Carboplatin_Cyclophosphamide	Chemotherapy_Regimen	Amifostine/Carboplatin/Cyclophosphamide|CBDCA/CTX/WR-2721
C11319	Cyclosporine_Mycophenolate-Mofetil	Chemotherapy_Regimen	Cyclosporine/Mycophenolate Mofetil|CYSP/MMF
C11320	gp100-Antigen_Incomplete-Freunds-Adjuvant_MART-1Antigen_sargramostim_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant/MART-1 Antigen/Sargramostim/Tyrosinase Peptide|GM-CSF/GP100/IFA/MART-1/TYRP
C11321	Bismuth-Subcitrate_Metronidazole_Omeprazole_Tetracycline	Chemotherapy_Regimen	Bismuth Subcitrate/Metronidazole/Omeprazole/Tetracycline|BISSUBCIT/METRO/OMEP/TETRA
C11322	Amoxicillin_Clarithromycin_Omeprazole	Chemotherapy_Regimen	Amoxicillin/Clarithromycin/Omeprazole|AMOX/CLARITH/OMEP
C11323	Incomplete-Freunds-Adjuvant_Interleukin-2_Tyrosinase-Peptide	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/Interleukin-2/Tyrosinase Peptide|IFA/IL-2/TYRP
C11324	gp100-Antigen_Incomplete-Freunds-Adjuvant_Sargramostim	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant/Sargramostim|GM-CSF/gp100/IFA
C11325	Incomplete-Freunds-Adjuvant_Sargramostim_Tyrosinase-Peptide	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/Sargramostim/Tyrosinase Peptide|GM-CSF/IFA/TYRP
C11326	Incomplete-Freunds-Adjuvant_Interleukin-12_Tyrosinase-Peptide	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/Interleukin-12/Tyrosinase Peptide|IFA/IL-12/TYRP
C11327	Incomplete-Freunds-Adjuvant_Interleukin-2_Tyrosinase-Related-Protein-1	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/Interleukin-2/Tyrosinase Related Protein-1|IFA/IL-2/TRP-1
C11328	Incomplete-Freunds-Adjuvant_Sargramostim_Tyrosinase-Related-Protein-1	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/Sargramostim/Tyrosinase Related Protein-1|GM-CSF/IFA/TRP-1
C11329	Carboplatin_Cisplatin_Floxuridine	Chemotherapy_Regimen	Carboplatin/Cisplatin/Floxuridine|CBDCA/CDDP/FUDR
C11330	Carboplatin_Floxuridine	Chemotherapy_Regimen	Carboplatin/Floxuridine|CBDCA/FUDR
C11331	Cisplatin_Floxuridine	Chemotherapy_Regimen	Cisplatin/Floxuridine|CDDP/FUDR
C11332	Amifostine_Cisplatin_Gemcitabine	Chemotherapy_Regimen	Amifostine/Cisplatin/Gemcitabine|CDDP/dFdC/WR-2721
C11333	Bryostatin-1_Cladribine	Chemotherapy_Regimen	Bryostatin 1/Cladribine|BRYO/2-CdA
C11334	Cladribine_Idarubicin	Chemotherapy_Regimen	Cladribine/Idarubicin|2-CdA/IDA
C11335	Buserelin_Flutamide	Chemotherapy_Regimen	Buserelin/Flutamide|BSRL/FLUT
C11336	Buserelin_Nilutamide	Chemotherapy_Regimen	Buserelin/Nilutamide|ANAN/BSRL
C11337	Bicalutamide_Buserelin	Chemotherapy_Regimen	Bicalutamide/Buserelin|BSRL/CDX
C11338	Leuprolide_Nilutamide	Chemotherapy_Regimen	Leuprolide/Nilutamide|ANAN/LEUP
C11339	Histamine-Dihydrochloride_Interleukin-2	Chemotherapy_Regimen	Histamine Dihydrochloride/Interleukin-2|HIST/IL-2
C11340	Carboplatin_Etoposide_Fluorouracil	Chemotherapy_Regimen	Carboplatin/Etoposide/Fluorouracil|CBDCA/5-FU/VP-16
C11341	Amifostine_Fludarabine	Chemotherapy_Regimen	Amifostine/Fludarabine|FAMP/WR-2721
C11342	Flt3-Ligand_gp100-Antigen	Chemotherapy_Regimen	Flt3 Ligand/gp100 Antigen|Flt3L/gp100
C11343	Bleomycin_Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Doxorubicin/Etoposide/Prednisone/Vincristine|BLEO/CTX/DOX/PRED/VCR/VP-16
C11344	Bleomycin_Cyclophosphamide_dexrazoxane_Doxorubicin_Etoposide_Prednisone_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Dexrazoxane/Doxorubicin/Etoposide/Prednisone/Vincristine|ADR-529/BLEO/CTX/DOX/PRED/VCR/VP-16
C11345	Doxorubicin-HCl-Liposome_PSC-833	Chemotherapy_Regimen	Doxorubicin HCl Liposome/PSC 833|Lipodox/PSC 833
C11346	Amifostine_Busulfan_Melphalan_Thiotepa	Chemotherapy_Regimen	Amifostine/Busulfan/Melphalan/Thiotepa|BU/L-PAM/TSPA/WR-2721
C11347	Ifosfamide_Topotecan	Chemotherapy_Regimen	Ifosfamide/Topotecan|IFF/TOPO
C11348	Cytarabine_Daunorubicin_Etoposide_PSC-833	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Etoposide/PSC 833|ARA-C/DNR/PSC 833/VP-16
C11349	Mitoxantrone_Vinorelbine	Chemotherapy_Regimen	Mitoxantrone/Vinorelbine|DHAD/VNB
C11350	Docetaxel_Fluorouracil	Chemotherapy_Regimen	Docetaxel/Fluorouracil|5-FU/TXT
C11351	Carboplatin_Thiotepa_Topotecan	Chemotherapy_Regimen	Carboplatin/Thiotepa/Topotecan|CBDCA/TOPO/TSPA
C11352	Amifostine_Cisplatin_Cytarabine_Dexamethasone	Chemotherapy_Regimen	Amifostine/Cisplatin/Cytarabine/Dexamethasone|ARA-C/CDDP/DM/WR-2721
C11353	Interleukin-2_Sargramostim_Vinblastine	Chemotherapy_Regimen	Interleukin-2/Sargramostim/Vinblastine|GM-CSF/IL-2/VBL
C11354	Peptide-946-Melanoma-Vaccine_QS21	Chemotherapy_Regimen	Peptide 946 Melanoma Vaccine/QS21|p946/QS21
C11355	Peptide-946-Melanoma-Vaccine_QS21_Tetanus-Peptide-Melanoma-Vaccine	Chemotherapy_Regimen	Peptide 946 Melanoma Vaccine/QS21/Tetanus Peptide Melanoma Vaccine
C11356	Interleukin-2_Monoclonal-Antibody-3622W94_Sargramostim	Chemotherapy_Regimen	Interleukin-2/Monoclonal Antibody 3622W94/Sargramostim|GM-CSF/IL-2/MOAB 3622W94
C11357	Interleukin-2_Monoclonal-Antibody-3622W94	Chemotherapy_Regimen	Interleukin-2/Monoclonal Antibody 3622W94|IL-2/MOAB 3622W94
C11358	ALVAC-CEA-Vaccine_Sargramostim	Chemotherapy_Regimen	ALVAC-CEA Vaccine/Sargramostim|ALVAC-CEA/GM-CSF
C11359	Amifostine_Irinotecan	Chemotherapy_Regimen	Amifostine/Irinotecan|CPT-11/WR-2721
C11360	Dexamethasone_Metoclopramide	Chemotherapy_Regimen	Dexamethasone/Metoclopramide|DM/MCP
C11361	Dexamethasone_Granisetron	Chemotherapy_Regimen	Dexamethasone/Granisetron|DM/GRAN
C11362	Bryostatin-1_Paclitaxel	Chemotherapy_Regimen	Bryostatin 1/Paclitaxel
C11363	Interferon-Alfa_Isotretinoin_Vitamin-E	Chemotherapy_Regimen	Interferon Alfa/Isotretinoin/Vitamin E|13-CRA/IFN-A/VIT-E
C11364	Cytarabine_Homoharringtonine_Interferon-Alfa	Chemotherapy_Regimen	Cytarabine/Homoharringtonine/Interferon Alfa|ARA-C/HH/IFN-A
C11365	Leucovorin-Calcium_Methotrexate_Vincristine	Chemotherapy_Regimen	Leucovorin Calcium/Methotrexate/Vincristine|CF/MTX/VCR
C11366	Clodronate_Mitoxantrone_Prednisone	Chemotherapy_Regimen	Clodronate/Mitoxantrone/Prednisone|CLOD/DHAD/PRED
C11367	Mitoxantrone_Prednisone	Chemotherapy_Regimen	Mitoxantrone/Prednisone|DHAD/PRED
C11368	Cladribine_Cyclophosphamide_Prednisone	Chemotherapy_Regimen	Cladribine/Cyclophosphamide/Prednisone|2-CdA/CTX/PRED
C11369	Cytarabine_Cyclophosphamide_Dexamethasone_Doxorubicin_Methotrexate_Vincristine	Chemotherapy_Regimen	Cytarabine/Cyclophosphamide/Dexamethasone/Doxorubicin/Methotrexate/Vincristine|ARA-C/CTX/DM/DOX/MTX/VCR|Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Methotrexate/Vincristine
C11370	Interferon-Alfa_Ritonavir	Chemotherapy_Regimen	Interferon Alfa/Ritonavir|IFN-A/RIT
C11371	Fludarabine_Rituximab	Chemotherapy_Regimen	Fludarabine/Rituximab|FAMP/MOAB IDEC-C2B8|rituximab/fludarabine
C11372	Cyclophosphamide_Mercaptopurine_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Mercaptopurine/Methotrexate|CTX/MP/MTX
C11373	Carboxyamidotriazole_Ketoconazole	Chemotherapy_Regimen	Carboxyamidotriazole/Ketoconazole|CAI/KCZ
C11374	Mycophenolate-Mofetil_Tacrolimus	Chemotherapy_Regimen	Mycophenolate Mofetil/Tacrolimus|FK506/MMF
C11375	Omeprazole_Porfimer-Sodium	Chemotherapy_Regimen	Omeprazole/Porfimer Sodium|DHE/OMEP
C11376	Cisplatin_docetaxel_Fluorouracil	Chemotherapy_Regimen	Cisplatin/Docetaxel/Fluorouracil|CDDP/5-FU/TXT
C11377	Amifostine_Cisplatin_Cyclophosphamide_Etoposide	Chemotherapy_Regimen	Amifostine/Cisplatin/Cyclophosphamide/Etoposide|CDDP/CTX/VP-16/WR-2721
C11378	Cyproterone_Luteinizing-Hormone-Releasing-Factor	Chemotherapy_Regimen	Cyproterone/Luteinizing Hormone-Releasing Factor|CPTR/LHRH
C11379	Octreotide_Prednisone	Chemotherapy_Regimen	Octreotide/Prednisone|PRED/SSTN
C11380	Carboplatin_Estramustine_Filgrastim_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Estramustine/Filgrastim/Paclitaxel|CBDCA/EM/G-CSF/TAX
C11381	BCG_Monoclonal-Antibody-BEC2	Chemotherapy_Regimen	BCG/Monoclonal Antibody BEC2|BCG/MOAB BEC2
C11382	Cyclophosphamide_Tirapazamine	Chemotherapy_Regimen	Cyclophosphamide/Tirapazamine|CTX/SR-4233
C11383	Amifostine_Cytarabine_Idarubicin	Chemotherapy_Regimen	Amifostine/Cytarabine/Idarubicin|ARA-C/IDA/WR-2721
C11384	Fluorouracil_Trimetrexate-Glucuronate	Chemotherapy_Regimen	Fluorouracil/Trimetrexate Glucuronate|5-FU/TMTX
C11385	Cisplatin_Fluorouracil_ONYX-015	Chemotherapy_Regimen	Cisplatin/Fluorouracil/ONYX-015|CDDP/5-FU/ONYX-015
C11386	Mitoxantrone_Thiotepa_Topotecan	Chemotherapy_Regimen	Mitoxantrone/Thiotepa/Topotecan|DHAD/TOPO/TSPA
C11387	Amifostine_Carboplatin_Filgrastim_Paclitaxel	Chemotherapy_Regimen	Amifostine/Carboplatin/Filgrastim/Paclitaxel|CBDCA/G-CSF/TAX/WR-2721
C11388	Cytarabine_Daunorubicin_Interleukin-11_Sargramostim	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Interleukin-11/Sargramostim|ARA-C/DNR/GM-CSF/IL-11
C11389	Interleukin-11_Sargramostim	Chemotherapy_Regimen	Interleukin-11/Sargramostim|GM-CSF/IL-11
C11390	gp100-Antigen_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Tyrosinase Peptide|gp100/TYRP
C11391	Bryostatin-1_Interleukin-2_Lonomycin	Chemotherapy_Regimen	Bryostatin 1/Interleukin-2/Ionomycin|BRYO/IL-2/IONO
C11392	Finasteride_Flutamide	Chemotherapy_Regimen	Finasteride/Flutamide|FLUT/MK-906
C11393	Cyclophosphamide_DPPE	Chemotherapy_Regimen	Cyclophosphamide/DPPE|CTX/DPPE
C11394	Busulfan_Cyclophosphamide_Anti-Thymocyte-Globulin	Chemotherapy_Regimen	Busulfan/Cyclophosphamide/Anti-Thymocyte Globulin|ATG/BU/CTX
C11395	Cyclophosphamide_Methylprednisolone	Chemotherapy_Regimen	Cyclophosphamide/Methylprednisolone|CTX/MePRDL
C11396	Busulfan_Cyclophosphamide_Methylprednisolone	Chemotherapy_Regimen	Busulfan/Cyclophosphamide/Methylprednisolone|BU/CTX/MePRDL
C11397	AG3340_Carboplatin_Paclitaxel	Chemotherapy_Regimen	AG3340/Carboplatin/Paclitaxel|AG3340/CBDCA/TAX
C11398	Docetaxel_Doxorubicin-HCl-Liposome	Chemotherapy_Regimen	Docetaxel/Doxorubicin HCl Liposome|LipoDox/TXT
C11399	Carboplatin_Lomustine_Procarbazine_Vincristine	Chemotherapy_Regimen	Carboplatin/Lomustine/Procarbazine/Vincristine|CBDCA/CCNU/PCB/VCR
C11400	Cisplatin_Cyclophosphamide_Etoposide_Leucovorin-calcium_Methotrexate_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Etoposide/Leucovorin calcium/Methotrexate/Vincristine|CDDP/CF/CTX/MTX/VCR/VP-16
C11401	Doxorubicin-HCl-Liposome_Paclitaxel	Chemotherapy_Regimen	Doxorubicin HCl Liposome/Paclitaxel|LipoDox/TAX
C11402	Carboplatin_Thalidomide	Chemotherapy_Regimen	Carboplatin/Thalidomide|CBDCA/THAL
C11403	Filgrastim_Pegylated-Recombinant-Human-Megakaryocyte-Growth-and-Development-Factor	Chemotherapy_Regimen	Filgrastim/Pegylated Recombinant Human Megakaryocyte Growth and Development Factor|Filgrastim/Pegylated Recombinant Human Megakaryocyte Growth and developmentfactor|G-CSF/PEG-MGDF
C11404	gp100-Antigen_Incomplete-Freunds-Adjuvant_Interleukin-12_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant/Interleukin-12/Tyrosinase Peptide|gp100/IFA/IL-12/TYRP
C11405	gp100-Antigen_Incomplete-Freunds-Adjuvant_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant/Tyrosinase Peptide|gp100/IFA/TYRP
C11406	Acetaminophen_Acetylcysteine_Carmustine	Chemotherapy_Regimen	Acetaminophen/Acetylcysteine/Carmustine|ACMP/BCNU/NAC
C11407	Acetaminophen_Acetylcysteine	Chemotherapy_Regimen	Acetaminophen/Acetylcysteine|ACMP/NAC
C11408	Filgrastim_Promegapoietin	Chemotherapy_Regimen	Filgrastim/Promegapoietin|G-CSF/PMP
C11409	Doxorubicin-HCl-Liposome_Topotecan	Chemotherapy_Regimen	Doxorubicin HCl Liposome/Topotecan|LipoDox/TOPO
C11410	Ciprofloxacin_Dexamethasone_Pentoxifylline	Chemotherapy_Regimen	Ciprofloxacin/Dexamethasone/Pentoxifylline|CPFX/DM/PTX
C11411	Cisplatin_LY231514	Chemotherapy_Regimen	Cisplatin/LY231514|CDDP/LY231514
C11412	Etoposide_Gemcitabine	Chemotherapy_Regimen	Etoposide/Gemcitabine|dFdC/VP-16
C11413	Carboplatin_Doxorubicin-HCl-Liposome_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Doxorubicin HCl Liposome/Paclitaxel|CBDCA/LipoDox/TAX
C11414	Carboplatin_Gemcitabine_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Gemcitabine/Paclitaxel|CBDCA/dFdC/TAX
C11415	gp100-Antigen_Sargramostim_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Sargramostim/Tyrosinase Peptide|gp100/GM-CSF/TYRP
C11416	Fluorouracil_Paclitaxel	Chemotherapy_Regimen	Fluorouracil/Paclitaxel|5-FU/TAX
C11417	Bryostatin-1_Fludarabine	Chemotherapy_Regimen	Bryostatin 1/Fludarabine|BRYO/FAMP
C11418	BMS-182751_Prednisone	Chemotherapy_Regimen	BMS-182751/Prednisone|BMS-182751/PRED
C11419	Doxorubicin-HCl-Liposome_Etoposide	Chemotherapy_Regimen	Doxorubicin HCl Liposome/Etoposide|LipoDox/VP-16
C11420	Anti-Thymocyte-Globulin_Busulfan_Melphalan	Chemotherapy_Regimen	Anti-Thymocyte Globulin/Busulfan/Melphalan|ATG/BU/L-PAM
C11421	Busulfan_Melphalan_Methylprednisolone	Chemotherapy_Regimen	Busulfan/Melphalan/Methylprednisolone|BU/L-PAM/MePRDL
C11422	Interleukin-2_Rituximab	Chemotherapy_Regimen	Interleukin-2/Rituximab|IL-2/MOAB IDEC-C2B8
C11423	Amifostine_Cytarabine_Mitoxantrone	Chemotherapy_Regimen	Amifostine/Cytarabine/Mitoxantrone|ARA-C/DHAD/WR-2721
C11424	Gemcitabine_Topotecan	Chemotherapy_Regimen	Gemcitabine/Topotecan|dFdC/TOPO
C11425	Cyclophosphamide_Docetaxel_Doxorubicin	Chemotherapy_Regimen	Cyclophosphamide/Docetaxel/Doxorubicin|CTX/DOX/TXT
C11426	Cyclophosphamide_Doxorubicin-HCl-Liposome_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin HCl Liposome/Prednisone/Vincristine|CTX/LipoDox/PRED/VCR
C11427	Cyclophosphamide_Daunorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Daunorubicin/Prednisone/Vincristine|CTX/DNR/PRED/VCR
C11428	Incomplete-Freunds-Adjuvant_Peptide-946-Melanoma-Vaccine	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/Peptide 946 Melanoma Vaccine|IFA/p946
C11429	Carmustine_Melphalan	Chemotherapy_Regimen	Carmustine/Melphalan|BCNU/L-PAM
C11430	Gemcitabine_Paclitaxel	Chemotherapy_Regimen	Gemcitabine/Paclitaxel|dFdC/TAX
C11431	Chlorambucil_Doxorubicin_Etoposide_Prednisolone_Procarbazine_Vinblastine_Vincristine	Chemotherapy_Regimen	Chlorambucil/Doxorubicin/Etoposide/Prednisolone/Procarbazine/Vinblastine/Vincristine|CLB/DOX/PCB/PRDL/VBL/VCR/VP-16
C11432	Gemcitabine_Vinorelbine	Chemotherapy_Regimen	Gemcitabine/Vinorelbine|dFdC/VNB
C11433	Cytarabine_Daunorubicin_Etoposide_Methotrexate_Prednisolone_Thioguanine_Vincristine	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Etoposide/Methotrexate/Prednisolone/Thioguanine/Vincristine|ARA-C/DNR/MTX/PRDL/TG/VCR/VP-16
C11434	Cyclophosphamide_Cytarabine_Methotrexate_Thioguanine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Methotrexate/Thioguanine|ARA-C/CTX/MTX/TG
C11435	BAY-12-9566_Doxorubicin	Chemotherapy_Regimen	BAY 12-9566/Doxorubicin|BAY 12-9566/DOX
C11436	BAY-12-9566_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	BAY 12-9566/Fluorouracil/Leucovorin Calcium
C11437	Asparaginase_Methotrexate_Prednisolone_Vincristine	Chemotherapy_Regimen	Asparaginase/Methotrexate/Prednisolone/Vincristine|ASP/MTX/PRDL/VCR
C11438	Interferon-Alfa_Interleukin-12	Chemotherapy_Regimen	Interferon Alfa/Interleukin-12|IFN-A/IL-12
C11439	Carcinoembryonic-Antigen-Peptide-1_Hepatitis-B-Antigen-Peptide	Chemotherapy_Regimen	Carcinoembryonic Antigen Peptide 1/Hepatitis B Antigen Peptide|CAP-1/HBsAg
C11440	Carmustine_Gemcitabine_Melphalan	Chemotherapy_Regimen	Carmustine/Gemcitabine/Melphalan|BCNU/dFdC/L-PAM
C11441	Cisplatin_Cyclophosphamide_Dexamethasone_Etoposide_Gemcitabine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Dexamethasone/Etoposide/Gemcitabine|CDDP/CTX/dFdC/DM/VP-16
C11442	Irinotecan_Oxaliplatin	Chemotherapy_Regimen	Irinotecan/Oxaliplatin|CPT-11/L-OHP
C11443	Cisplatin_Floxuridine_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Floxuridine/Paclitaxel|CDDP/FUDR/TAX
C11444	Cisplatin_Cyclophosphamide_Dexamethasone_Etoposide	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Dexamethasone/Etoposide|CDDP/CTX/DM/VP-16
C11445	Interferon-Alfa_Interleukin-2_Sargramostim	Chemotherapy_Regimen	Interferon Alfa/Interleukin-2/Sargramostim|GM-CSF/IFN-A/IL-2
C11446	Amifostine_Epoetin-Alfa	Chemotherapy_Regimen	Amifostine/Epoetin Alfa|EPO/WR-2721
C11447	Incomplete-Freunds-Adjuvant_Von-Hippel-Lindau-Peptide-Vaccine	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/Von Hippel-Lindau Peptide Vaccine|IFA/VHL peptide
C11448	Incomplete-Freunds-Adjuvant_Sargramostim_Von-Hippel-Lindau-Peptide-Vaccine	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/Sargramostim/Von Hippel-Lindau Peptide Vaccine|GM-CSF/IFA/VHL peptide
C11449	Carmustine_Fluorouracil_Streptozocin_Vincristine	Chemotherapy_Regimen	Carmustine/Fluorouracil/Streptozocin/Vincristine|BCNU/5-FU/SZC/VCR
C11450	Adenovirus-5-CD40-L-Vector_Interleukin-2	Chemotherapy_Regimen	Adenovirus 5-CD40-L Vector/Interleukin-2|AD-CD40-L/IL-2
C11451	Cyclophosphamide_Prednisone_Sargramostim_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Prednisone/Sargramostim/Vincristine|CTX/GM-CSF/PRED/VCR
C11452	Isotretinoin_Procarbazine	Chemotherapy_Regimen	Isotretinoin/Procarbazine|13-CRA/PCB
C11453	Anti-Thymocyte-Globulin_Cyclophosphamide_Fludarabine	Chemotherapy_Regimen	Anti-Thymocyte Globulin/Cyclophosphamide/Fludarabine|ATG/CTX/FAMP
C11454	Dexamethasone_Methotrexate_Thioguanine_Vincristine	Chemotherapy_Regimen	Dexamethasone/Methotrexate/Thioguanine/Vincristine|DM/MTX/TG/VCR
C11455	Methotrexate_Prednisolone_Thioguanine_Vincristine	Chemotherapy_Regimen	Methotrexate/Prednisolone/Thioguanine/Vincristine|MTX/PRDL/TG/VCR
C11456	Flt3-Ligand_gp100-Antigen_MART-1-Antigen_Tyrosinase	Chemotherapy_Regimen	Flt3 Ligand/gp100 Antigen/MART-1 Antigen/Tyrosinase|Flt3L/gp100/MART-1/TYR
C11457	Flt3-Ligand_gp100-Antigen_Incomplete-Freunds-Adjuvant_MART-1Antigen_Tyrosinase	Retired_Concepts	Flt3 Ligand/gp100 Antigen/Incomplete Freund's Adjuvant/MART-1 Antigen/Tyrosinase|Flt3L/gp100/IFA/MART-1/TYR
C11458	Carboplatin_Docetaxel	Chemotherapy_Regimen	Carboplatin/Docetaxel|CBDCA/TXT
C11459	Cisplatin_Dexamethasone_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Dexamethasone/Paclitaxel|CDDP/DM/TAX
C11460	Cisplatin_Cyclophosphamide_Epirubicin_Etoposide	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Epirubicin/Etoposide|CDDP/CTX/EPI/VP-16
C11461	Interferon-Alfa_Sargramostim	Chemotherapy_Regimen	Interferon Alfa/Sargramostim|GM-CSF/IFN-A
C11462	Cisplatin_Dimesna_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Dimesna/Paclitaxel|CDDP/DIM/TAX
C11463	Etoposide_Idarubicin	Chemotherapy_Regimen	Etoposide/Idarubicin|IDA/VP-16
C11464	Cytarabine_Idarubicin_Recombinant-Human-Thrombopoietin	Chemotherapy_Regimen	Cytarabine/Idarubicin/Recombinant Human Thrombopoietin|ARA-C/IDA/rhTPO
C11465	Cyclophosphamide_Cytarabine_Hydrocortisone_Leucovorin-Calcium	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Hydrocortisone/Leucovorin Calcium|ARA-C/CF/CTX/HC
C11466	Fenretinide_Tretinoin	Chemotherapy_Regimen	Fenretinide/Tretinoin|ATRA/HPR
C11467	Melphalan_Prednisolone	Chemotherapy_Regimen	Melphalan/Prednisolone|L-PAM/PRDL
C11468	Dexamethasone_Idarubicin_Lomustine	Chemotherapy_Regimen	Dexamethasone/Idarubicin/Lomustine|CCNU/DM/IDA
C11469	Carboplatin_Gemcitabine	Chemotherapy_Regimen	Carboplatin/Gemcitabine|CBDCA/dFdC
C11470	Filgrastim_Sargramostim	Chemotherapy_Regimen	Filgrastim/Sargramostim|G-CSF/GM-CSF
C11471	gp209-2M-Antigen_Incomplete-Freunds-Adjuvant_Interleukin-2	Chemotherapy_Regimen	gp209-2M Antigen/Incomplete Freund's Adjuvant/Interleukin-2|gp209-2M/IFA/IL-2
C11472	Cyclophosphamide_Rituximab	Chemotherapy_Regimen	Cyclophosphamide/Rituximab|CTX/MOAB IDEC-C2B8
C11473	Docetaxel_Estramustine_Mitoxantrone_Prednisone	Chemotherapy_Regimen	Docetaxel/Estramustine/Mitoxantrone/Prednisone|EM/DHAD/PRED/TXT
C11474	Cyclosporine_Etoposide_Vincristine	Chemotherapy_Regimen	Cyclosporine/Etoposide/Vincristine|CYSP/VCR/VP-16
C11475	Bleomycin_Cisplatin_Etoposide_Paclitaxel	Chemotherapy_Regimen	Bleomycin/Cisplatin/Etoposide/Paclitaxel|BLEO/CDDP/TAX/VP-16
C11476	Cytarabine_Fludarabine_Topotecan	Chemotherapy_Regimen	Cytarabine/Fludarabine/Topotecan|ARA-C/FAMP/TOPO
C11477	Chlorambucil_Dexamethasone_Idarubicin	Chemotherapy_Regimen	Chlorambucil/Dexamethasone/Idarubicin|CLB/DM/IDA
C11478	Chlorambucil_Dexamethasone	Chemotherapy_Regimen	Chlorambucil/Dexamethasone|CLB/DM
C11479	Cytarabine_Etoposide_Melphalan	Chemotherapy_Regimen	Cytarabine/Etoposide/Melphalan|ARA-C/L-PAM/VP-16
C11480	Cytarabine_Daunorubicin_Filgrastim	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Filgrastim|ARA-C/DNR/G-CSF
C11481	Antineoplaston-A10_Methotrexate	Chemotherapy_Regimen	Antineoplaston A10/Methotrexate|A10/MTX
C11482	Cyclophosphamide_THERATOPE-STn-KLH-Vaccine	Chemotherapy_Regimen	Cyclophosphamide/Theratope STn-KLH Vaccine|CTX/THERATOPE
C11483	Fluorouracil_Gemcitabine_Interferon-Alfa_Interleukin-2	Chemotherapy_Regimen	Fluorouracil/Gemcitabine/Interferon Alfa/Interleukin-2|DFdC/5-FU/IFN-A/IL-2
C11484	Interferon-Alfa_Tretinoin-Liposome	Chemotherapy_Regimen	Interferon Alfa/Tretinoin Liposome|IFN-A/L-ATRA
C11485	Doxorubicin_Methylprednisolone	Chemotherapy_Regimen	Doxorubicin/Methylprednisolone|DOX/MePRDL
C11486	Clarithromycin_Omeprazole_Tinidazole	Chemotherapy_Regimen	Clarithromycin/Omeprazole/Tinidazole|CLARITH/OMEP/TDZ
C11487	Cyclophosphamide_Pentostatin	Chemotherapy_Regimen	Cyclophosphamide/Pentostatin|CTX/DCF
C11488	Phenylbutyrate_Tretinoin	Chemotherapy_Regimen	Phenylbutyrate/Tretinoin|ATRA/PBA
C11489	Asparaginase_Dexamethasone_Mercaptopurine_Vincristine	Chemotherapy_Regimen	Asparaginase/Dexamethasone/Mercaptopurine/Vincristine|ASP/DM/MP/VCR
C11490	Asparaginase_Daunorubicin_Dexamethasone_Vincristine	Chemotherapy_Regimen	Asparaginase/Daunorubicin/Dexamethasone/Vincristine|ASP/DM/DNR/VCR
C11491	Dexamethasone_Leucovorin-Calcium_Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Dexamethasone/Leucovorin Calcium/Mercaptopurine/Methotrexate/Vincristine|CF/DM/MP/MTX/VCR
C11492	Asparaginase_Cyclophosphamide_Cytarabine_Daunorubicin_Dexamethasone_Mercaptopurine_Methotrexate_Thioguanine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Daunorubicin/Dexamethasone/Mercaptopurine/Methotrexate/Thioguanine/Vincristine|ARA-C/ASP/CTX/DM/DNR/MP/MTX/TG/VCR
C11493	Dexamethasone_Rituximab	Chemotherapy_Regimen	Dexamethasone/Rituximab|DM/MOAB IDEC-C2B8
C11494	Interferon-Alfa_Interleukin-2-Liposome_Polyvalent-Melanoma-Vaccine	Chemotherapy_Regimen	Interferon Alfa/Interleukin-2 Liposome/Polyvalent Melanoma Vaccine|IFN-A/IL-2 LIPO/POLYMELVAC
C11495	Asparaginase_Dexamethasone_Etoposide_Mitoxantrone	Chemotherapy_Regimen	Asparaginase/Dexamethasone/Etoposide/Mitoxantrone|ASP/DHAD/DM/VP-16
C11496	Asparaginase_Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Asparaginase/Mercaptopurine/Methotrexate/Vincristine|ASP/MP/MTX/VCR
C11497	Cytarabine_Mercaptopurine_Methotrexate_Prednisone	Chemotherapy_Regimen	Cytarabine/Mercaptopurine/Methotrexate/Prednisone|ARA-C/MP/MTX/PRED
C11498	Methotrexate_Methylprednisolone	Chemotherapy_Regimen	Methotrexate/Methylprednisolone|MTX/MePRDL
C11499	Carboplatin_Melphalan	Chemotherapy_Regimen	Carboplatin/Melphalan|CBDCA/L-PAM
C11500	Cisplatin_Flavopiridol	Chemotherapy_Regimen	Cisplatin/Flavopiridol|CDDP/FLAVO
C11501	Amifostine_Etoposide	Chemotherapy_Regimen	Amifostine/Etoposide|VP-16/WR-2721
C11502	Gemcitabine_R115777	Chemotherapy_Regimen	Gemcitabine/R115777|dFdC/R115777
C11503	Amifostine_Carboplatin_Etoposide_Ifosfamide	Chemotherapy_Regimen	Amifostine/Carboplatin/Etoposide/Ifosfamide|CBDCA/IFF/VP-16/WR-2721
C11504	Cyclophosphamide_Cytarabine_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Methotrexate|ARA-C/CTX/MTX
C11505	Dextromethorphan_Morphine	Chemotherapy_Regimen	Dextromethorphan/Morphine|DEX/MORPH
C11506	Cytarabine_Hydrocortisone_Leucovorin-Calcium_Methotrexate	Chemotherapy_Regimen	Cytarabine/Hydrocortisone/Leucovorin Calcium/Methotrexate|ARA-C/CF/HC/MTX
C11507	Irinotecan_Mitomycin	Chemotherapy_Regimen	Irinotecan/Mitomycin|CPT-11/MITO
C11508	Capecitabine_Docetaxel	Chemotherapy_Regimen	Capecitabine/Docetaxel|CAPE/TXT
C11509	Cisplatin_Irinotecan_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Irinotecan/Paclitaxel|CDDP/CPT-11/TAX
C11510	Cyclophosphamide_Thalidomide	Chemotherapy_Regimen	Cyclophosphamide/Thalidomide|CTX/THAL
C11511	Dexamethasone_Floxuridine_Irinotecan	Chemotherapy_Regimen	Dexamethasone/Floxuridine/Irinotecan|CPT-11/DM/FUDR
C11512	Flutamide_Triptorelin	Chemotherapy_Regimen	Flutamide/Triptorelin|FLUT/TRIP
C11513	Carboplatin_Temozolomide	Chemotherapy_Regimen	Carboplatin/Temozolomide|CBDCA/TMZ
C11514	Cisplatin_OXi-104	Chemotherapy_Regimen	Cisplatin/OXi-104|CDDP/OXi-104
C11515	Docetaxel_Gemcitabine	Chemotherapy_Regimen	Docetaxel/Gemcitabine|TXT/dFdC
C11516	Interleukin-2_Ras-Peptide-Cancer-Vaccine	Chemotherapy_Regimen	Interleukin-2/Ras Peptide Cancer Vaccine|IL-2/ras pep vac
C11517	Penicillamine_Pyridoxine	Chemotherapy_Regimen	Penicillamine/Pyridoxine|penicillamine/VIT-B6
C11518	Interferon-Alfa_Toremifene	Chemotherapy_Regimen	Interferon Alfa/Toremifene|IFN-A/TOR
C11519	Asparaginase_Dexamethasone_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Dexamethasone/Prednisone/Vincristine|ASP/DM/PRED/VCR
C11520	Carboplatin_Paclitaxel_PSC-833	Chemotherapy_Regimen	Carboplatin/Paclitaxel/PSC 833|CBDCA/PSC 833/TAX
C11521	Amifostine_Carmustine_Cyclophosphamide_Cytarabine_Etoposide	Chemotherapy_Regimen	Amifostine/Carmustine/Cyclophosphamide/Cytarabine/Etoposide|ARA-C/BCNU/CTX/VP-16/WR-2721
C11522	Amifostine_Carboplatin_Cyclophosphamide_Thiotepa	Chemotherapy_Regimen	Amifostine/Carboplatin/Cyclophosphamide/Thiotepa|CBDCA/CTX/TSPA/WR-2721
C11523	Fluorouracil_Oxaliplatin	Chemotherapy_Regimen	Fluorouracil/Oxaliplatin|5-FU/L-OHP
C11524	gp100-Antigen_MAGE-3-1_MART-1-Antigen_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/MAGE-3.1/MART-1 Antigen/Tyrosinase Peptide|gp100/MAGE-3.1/MART-1/TYRP
C11525	Flu-Matrix_gp100-Antigen_MAGE-3-1_MART-1-Antigen_Tyrosinase-Peptide	Chemotherapy_Regimen	Flu Matrix/gp100 Antigen/MAGE-3.1/MART-1 Antigen/Tyrosinase Peptide|Flu/Gp100/MAGE-3.1/MART-1/TYRP
C11526	Docetaxel_Doxorubicin_Tamoxifen	Chemotherapy_Regimen	Docetaxel/Doxorubicin/Tamoxifen|DOX/TMX/TXT
C11527	Cyclophosphamide_Docetaxel_Doxorubicin_Tamoxifen	Chemotherapy_Regimen	Cyclophosphamide/Docetaxel/Doxorubicin/Tamoxifen|CTX/DOX/TMX/TXT
C11528	Methotrexate_Prednisolone	Chemotherapy_Regimen	Methotrexate/Prednisolone|MTX/PRDL
C11529	Dexamethasone_Methotrexate	Chemotherapy_Regimen	Dexamethasone/Methotrexate|DM/MTX
C11530	Asparaginase_Daunorubicin_Dexamethasone_Methotrexate_Vincristine	Chemotherapy_Regimen	Asparaginase/Daunorubicin/Dexamethasone/Methotrexate/Vincristine|ASP/DM/DNR/MTX/VCR
C11531	Asparaginase_Cyclophosphamide_Daunorubicin_Methotrexate_Prednisolone_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Daunorubicin/Methotrexate/Prednisolone/Vincristine|ASP/CTX/DNR/MTX/PRDL/VCR
C11532	Asparaginase_Cytarabine_Mercaptopurine_Methotrexate	Chemotherapy_Regimen	Asparaginase/Cytarabine/Mercaptopurine/Methotrexate|ARA-C/ASP/MP/MTX
C11533	Asparaginase_Cyclophosphamide_Cytarabine_Mercaptopurine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Mercaptopurine|ARA-C/ASP/CTX/MP
C11534	Cytarabine_Methotrexate_Thioguanine	Chemotherapy_Regimen	Cytarabine/Methotrexate/Thioguanine|ARA-C/MTX/TG
C11535	Asparaginase_Leucovorin-Calcium_Mercaptopurine_Methotrexate	Chemotherapy_Regimen	Asparaginase/Leucovorin Calcium/Mercaptopurine/Methotrexate|ASP/CF/MP/MTX
C11536	Asparaginase_Cyclophosphamide_Daunorubicin_Dexamethasone_leucovorin-calcium_Methotrexate_Thioguanine_Vindesine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Daunorubicin/Dexamethasone/Leucovorin Calcium/Methotrexate/Thioguanine/Vindesine|ASP/CF/CTX/DAVA/DM/DNR/MTX/TG
C11537	Asparaginase_Cytarabine_Dexamethasone_leucovorin-calcium_Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Dexamethasone/Leucovorin Calcium/Mercaptopurine/Methotrexate/Vincristine|ARA-C/ASP/CF/DM/MP/MTX/VCR
C11538	Asparaginase_Cytarabine_Dexamethasone_Etoposide_Mitoxantrone	Chemotherapy_Regimen	Asparaginase/Cytarabine/Dexamethasone/Etoposide/Mitoxantrone|ARA-C/ASP/DHAD/DM/VP-16
C11539	Asparaginase_Cyclophosphamide_Cytarabine_Daunorubicin_Dexamethasone_Mercaptopurine_Methotrexate_Thioguanine_Vincristine_Vindesine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Daunorubicin/Dexamethasone/Mercaptopurine/Methotrexate/Thioguanine/Vincristine/Vindesine|ARA-C/ASP/CTX/DAVA/DM/DNR/MP/MTX/TG/VCR
C11540	Asparaginase_Daunorubicin_Methotrexate_Prednisolone_Vincristine	Chemotherapy_Regimen	Asparaginase/Daunorubicin/Methotrexate/Prednisolone/Vincristine|ASP/DNR/MTX/PRDL/VCR
C11541	Alendronate-Sodium_Ketoconazole	Chemotherapy_Regimen	Alendronate Sodium/Ketoconazole|KCZ/MK-217
C11542	Amifostine_Bleomycin_Cisplatin_Etoposide	Chemotherapy_Regimen	Amifostine/Bleomycin/Cisplatin/Etoposide|BLEO/CDDP/VP-16/WR-2721
C11543	Piperacillin_Tazobactam_Vancomycin	Chemotherapy_Regimen	Piperacillin/Tazobactam/Vancomycin|PIPER/TAZO/VANCO
C11544	Fowlpox-Virus-Vaccine_Interleukin-2	Chemotherapy_Regimen	Fowlpox Virus Vaccine/Interleukin-2|FOWLVAC/IL-2
C11545	Isotretinoin_Temozolomide	Chemotherapy_Regimen	Isotretinoin/Temozolomide|13-CRA/TMZ
C11546	Cyclosporine_Interferon-Alfa_Sargramostim	Chemotherapy_Regimen	Cyclosporine/Interferon Alfa/Sargramostim|CYSP/GM-CSF/IFN-A
C11547	Carboplatin_Paclitaxel_SCH-58500	Chemotherapy_Regimen	Carboplatin/Paclitaxel/SCH-58500|CBDCA/SCH-58500/TAX
C11548	Amifostine_Cytarabine_Topotecan	Chemotherapy_Regimen	Amifostine/Cytarabine/Topotecan|ARA-C/TOPO/WR-2721
C11549	Aminopterin_Leucovorin-Calcium	Chemotherapy_Regimen	Aminopterin/Leucovorin Calcium|APGA/CF
C11550	Carboplatin_Thiotepa_Vincristine	Chemotherapy_Regimen	Carboplatin/Thiotepa/Vincristine|CBDCA/TSPA/VCR
C11551	gp100-Antigen_Incomplete-Freunds-Adjuvant_MART-1-Antigen	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant/MART-1 Antigen|gp100/IFA/MART-1
C11552	gp100-Antigen_Incomplete-Freunds-Adjuvant_Interleukin-2_MART-1-Antigen	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant/Interleukin-2/MART-1 Antigen|gp100/IFA/IL-2/MART-1
C11553	Gentamicin_Piperacillin_Vancomycin	Chemotherapy_Regimen	Gentamicin/Piperacillin/Vancomycin
C11554	Asparaginase_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Prednisone/Vincristine|ASP/PRED/VCR|PVA|VLP|VPL
C11555	Cisplatin_Epirubicin	Chemotherapy_Regimen	Cisplatin/Epirubicin|CDDP-e TI|CDDP/EPI|Cisplatin-e therapeutic implant
C11556	Amikacin_Ceftazidime	Chemotherapy_Regimen	Amikacin/Ceftazidime
C11557	Amikacin_Ceftriaxone	Chemotherapy_Regimen	Amikacin/Ceftriaxone
C11558	Azacytidine_Carboplatin	Chemotherapy_Regimen	Azacytidine/Carboplatin|AZA/CBDCA
C11559	Cyclophosphamide_Detox-B-Adjuvant_Interleukin-2	Chemotherapy_Regimen	Cyclophosphamide/Detox-B Adjuvant/Interleukin-2
C11560	Deoxyspergualin_Monoclonal-Antibody-L6	Chemotherapy_Regimen	Deoxyspergualin/Monoclonal Antibody L6|DSG/MOAB L6
C11561	Fluorouracil_Interferon-Alfa_Leucovorin-Calcium_Mitoxantrone_Vinblastine	Chemotherapy_Regimen	Fluorouracil/Interferon Alfa/Leucovorin Calcium/Mitoxantrone/Vinblastine|CF/DHAD/5-FU/IFN-A/VBL
C11562	Doxorubicin_Pegaspargase_Prednisone_Vincristine	Chemotherapy_Regimen	Doxorubicin/Pegaspargase/Prednisone/Vincristine|DOX/PEG-ASP/PRED/VCR
C11563	Doxorubicin_Ifosfamide_Methotrexate_Muramyl-TriPeptide-Phosphatidylethanolamine	Chemotherapy_Regimen	Doxorubicin/Ifosfamide/Methotrexate/Muramyl Tripeptide Phosphatidylethanolamine|DOX/IFF/MTP-PE Liposome/MTX
C11564	Detox-B-Adjuvant_Keyhole-Limpet-Hemocyanin_Sialyl-Tn-Antigen	Chemotherapy_Regimen	Detox-B Adjuvant/Keyhole Limpet Hemocyanin/Sialyl Tn Antigen
C11565	Keyhole-Limpet-Hemocyanin_QS21_Sialyl-Tn-Antigen	Chemotherapy_Regimen	Keyhole Limpet Hemocyanin/QS21/Sialyl Tn Antigen|KLH/QS21/STn Antigen
C11566	Cyclophosphamide_Doxorubicin_Monoclonal-Antibody-HER2	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Monoclonal Antibody HER2|CTX/DOX/MOAB HER2
C11567	MAGE-3_PADRE-965-10	Retired_Concepts	MAGE-3/PADRE 965.10
C11568	Fluorouracil_Levamisole_Monoclonal-Antibody-17-1A	Chemotherapy_Regimen	Fluorouracil/Levamisole/Monoclonal Antibody 17-1A|5-FU/LEV/MOAB 17-1A
C11569	Monoclonal-Antibody-C225_Paclitaxel	Chemotherapy_Regimen	Monoclonal Antibody C225/Paclitaxel|MOAB C225/TAX
C11570	Doxorubicin_Monoclonal-Antibody-C225	Retired_Concepts	Doxorubicin/Monoclonal Antibody C225|DOX/MOAB C225
C11571	GM2-KLH-Vaccine_QS21	Chemotherapy_Regimen	GM2-KLH Vaccine/QS21|GM2-KLH/QS-21|GM2-KLH/QS21|GMK	A cancer vaccine based on the immunogenic ganglioside GM2, The GM2-KLH Vaccine/QS21 vaccine consists of GM2 conjugated with KLH keyhole limpet hemocyanin (KLH), a potent immunostimulant, and is admixed with the adjuvant QS21, a saponin fraction extracted from the bark of the South American tree Quillaja saponaria Molina. GM2 is a cell surface carbohydrate antigen expressed by most melanoma cells and various other tumor cell types. (NCI04)
C11572	Interferon-Alfa_Bexarotene	Chemotherapy_Regimen	Interferon Alfa/Bexarotene|Bexarotene/Interferon Alfa|IFN-A/LGD 1069|interferon alfa/LGD 1069
C11573	Cyclophosphamide_Epirubicin_Monoclonal-Antibody-HER2	Chemotherapy_Regimen	Cyclophosphamide/Epirubicin/Monoclonal Antibody HER2|CTX/EPI/MOAB HER2
C11574	Monoclonal-Antibody-HER2_Paclitaxel	Chemotherapy_Regimen	Monoclonal Antibody HER2/Paclitaxel|MOAB HER2/TAX
C11575	Fluorouracil_Leucovorin-Calcium_Monoclonal-Antibody-17-1A	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Monoclonal Antibody 17-1A|CF/5-FU/MOAB 17-1A
C11576	UFT_Leucovorin	Chemotherapy_Regimen	UFT/Leucovorin|Orzel|UFT/LV|tegafur/uracil/leucovorin	Orzel, also called UFT, is an oral formulation of uracil (U) and Tegafur (FT), a prodrug that breaks down to 5-FU and releases it slowly.
C11577	Epirubicin_Fluorouracil	Chemotherapy_Regimen	Epirubicin/Fluorouracil
C11578	gp100-Antigen_Incomplete-Freunds-Adjuvant_MART-1-Antigen_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant/MART-1 Antigen/Tyrosinase Peptide
C11579	gp100-Antigen_Incomplete-Freunds-Adjuvant_Interleukin-2_MART-1Antigen_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant/Interleukin-2/MART-1 Antigen/Tyrosinase Peptide|gp100/IFA/IL-2/MART-1/TYRP
C11580	gp100-Antigen_Incomplete-Freunds-Adjuvant_Interleukin-12_MART-1Antigen_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant/Interleukin-12/MART-1 Antigen/Tyrosinase Peptide|gp100/IFA/IL-12/MART-1/TYRP
C11581	Incomplete-Freunds-Adjuvant_Interleukin-12_Tyrosinase-Related-Protein-1	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/Interleukin-12/Tyrosinase Related Protein-1|Incomplete Freund's Adjuvant/Interleukin-12/Tyrosinase-Related Protein-1|Incomplete Freunds Adjuvant/Interleukin-12/Tyrosinase-Related Protein-1
C11582	Cisplatin_Monoclonal-Antibody-C225	Chemotherapy_Regimen	Cisplatin/Monoclonal Antibody C225|CDDP/MOAB C225
C11583	Incomplete-Freunds-Adjuvant_Peptide-946-Tetanus-Peptide-Conjugate-Melanoma-Vaccine	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/Peptide 946-Tetanus Peptide Conjugate Melanoma Vaccine|IFA/p946/Tet p
C11584	AG3340_Mitoxantrone_Prednisone	Chemotherapy_Regimen	AG3340/Mitoxantrone/Prednisone|AG3340/DHAD/PRED
C11585	QS21_Tn_c_KLH-Conjugate-Vaccine	Chemotherapy_Regimen	QS21/Tn(c)-KLH Conjugate Vaccine|QS21/Tn(c)-KLH
C11586	Cyclophosphamide_Etoposide_iodine-I-131-Monoclonal-Antibody-Anti-B1	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/iodine I 131 Monoclonal Antibody Anti-B1|CTX/I131-MOAB-B1/VP-16
C11587	gp100-Antigen_QS21_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/QS21/Tyrosinase Peptide|gp100/QS21/TYRP
C11588	Carboplatin_Docetaxel_Ifosfamide	Chemotherapy_Regimen	Carboplatin/Docetaxel/Ifosfamide|CBDCA/DTIC/IFF
C11589	Incomplete-Freunds-Adjuvant_Interleukin-2_Von-Hippel-Lindau-Peptide-Vaccine	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/Interleukin-2/Von Hippel-Lindau Peptide Vaccine|Incomplete Freund's IFA/IL-2/VHL peptide
C11590	ALVAC-hB7-1_Canarypox-hIL-12-Melanoma-Vaccine	Chemotherapy_Regimen	ALVAC-hB7.1/Canarypox-hIL-12 Melanoma Vaccine
C11591	Allovectin-7_Dacarbazine	Chemotherapy_Regimen	Allovectin-7/Dacarbazine
C11592	Carboplatin_Monoclonal-Antibody-HER2_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Monoclonal Antibody HER2/Paclitaxel|CBDCA/MOAB HER2/TAX
C11593	Irinotecan_LY231514	Chemotherapy_Regimen	Irinotecan/LY231514|CPT-11/LY231514
C11594	Interleukin-2_Monoclonal-Antibody-Anti-Tac	Chemotherapy_Regimen	Interleukin-2/Monoclonal Antibody Anti-Tac|IL-2/MOAB anti-Tac
C11595	IDEC-In2B8_Rituximab	Chemotherapy_Regimen	IDEC-In2B8/Rituximab
C11596	gp100-Antigen_MAGE-3_MART-1-Antigen_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/MAGE-3/MART-1 Antigen/Tyrosinase Peptide
C11597	Flu-Matrix_gp100-Antigen_MAGE-3_MART-1-Antigen_Tyrosinase-Peptide	Chemotherapy_Regimen	Flu Matrix/gp100 Antigen/MAGE-3/MART-1 Antigen/Tyrosinase Peptide
C11598	Gemcitabine_Monoclonal-Antibody-HER2	Chemotherapy_Regimen	Gemcitabine/Monoclonal Antibody HER2|dFdC/MOAB HER2
C11599	KSA-Glycoprotein_QS21	Chemotherapy_Regimen	KSA Glycoprotein/QS21
C11600	KSA-KLH-Conjugate-Vaccine_QS21	Chemotherapy_Regimen	KSA-KLH Conjugate Vaccine/QS21|KSA-KLH/QS21
C11601	QS21_TF_c_KLH-Conjugate-Vaccine	Chemotherapy_Regimen	QS21/TF(c)-KLH Conjugate Vaccine|QS21/TF(c)-KLH
C11602	Capecitabine_Irinotecan	Chemotherapy_Regimen	Capecitabine/Irinotecan
C11603	Iodine-I-125_Polifeprosan-20-With-Carmustine-Implant	Chemotherapy_Regimen	Iodine I 125/Polifeprosan 20 With Carmustine Implant
C11604	Amifostine_Cisplatin_Fluorouracil_Paclitaxel	Chemotherapy_Regimen	Amifostine/Cisplatin/Fluorouracil/Paclitaxel
C11605	Cisplatin_Flavopiridol_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Flavopiridol/Paclitaxel
C11606	Capecitabine_Vinorelbine	Chemotherapy_Regimen	Capecitabine/Vinorelbine
C11607	Fludarabine_Melphalan	Chemotherapy_Regimen	Fludarabine/Melphalan
C11608	Cyclophosphamide_Epirubicin_Fluorouracil_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Epirubicin/Fluorouracil/Methotrexate
C11609	Docetaxel_Irinotecan	Chemotherapy_Regimen	Docetaxel/Irinotecan
C11610	Fowlpox-Virus-Vaccine_Interleukin-2_Vaccinia-Tyrosinase-Vaccine	Chemotherapy_Regimen	Fowlpox Virus Vaccine/Interleukin-2/Vaccinia-Tyrosinase Vaccine
C11611	Interleukin-2_Vaccinia-Tyrosinase-Vaccine	Chemotherapy_Regimen	Interleukin-2/Vaccinia-Tyrosinase Vaccine
C11612	Amifostine_Cyclophosphamide_Doxorubicin_Paclitaxel	Chemotherapy_Regimen	Amifostine/Cyclophosphamide/Doxorubicin/Paclitaxel
C11613	Docetaxel_GEM-231	Chemotherapy_Regimen	Docetaxel/GEM 231
C11614	GEM-231_Paclitaxel	Chemotherapy_Regimen	GEM 231/Paclitaxel
C11615	Fluorouracil_Leucovorin-Calcium_SCH-66336	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/SCH 66336
C11616	Cytarabine_Daunorubicin_Tretinoin	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Tretinoin
C11617	Daunorubicin_Tretinoin	Chemotherapy_Regimen	Daunorubicin/Tretinoin
C11618	Fluorouracil-Uracil_Gemcitabine_Leucovorin-Calcium	Chemotherapy_Regimen	Fluorouracil-Uracil/Gemcitabine/Leucovorin Calcium
C11619	CRL-1005_gp100-Antigen_Incomplete-Freunds-Adjuvant_Tyrosinase-Peptide	Chemotherapy_Regimen	CRL 1005/gp100 Antigen/Incomplete Freund's Adjuvant/Tyrosinase Peptide
C11620	gp100-Antigen_Incomplete-Freunds-Adjuvant_Sargramostim_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant/Sargramostim/Tyrosinase Peptide
C11621	Methotrexate_Prednisone	Chemotherapy_Regimen	Methotrexate/Prednisone
C11622	Lomustine_Procarbazine	Chemotherapy_Regimen	Lomustine/Procarbazine
C11623	Leflunomide_Mitoxantrone	Chemotherapy_Regimen	Leflunomide/Mitoxantrone
C11624	Fluorouracil_Leucovorin-Calcium_SU5416	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/SU5416
C11625	Cyclosporine_Irinotecan	Chemotherapy_Regimen	Cyclosporine/Irinotecan
C11626	Detoxpc_Lung-Tumor-Associated-Antigen	Chemotherapy_Regimen	Detoxpc/Lung Tumor Associated Antigen
C11627	Anti-Thymocyte-Globulin_Methylprednisolone	Chemotherapy_Regimen	Anti-thymocyte globulin/Methylprednisolone
C11628	Anti-Thymocyte-Globulin_Cyclophosphamide_Methylprednisolone	Chemotherapy_Regimen	Anti-thymocyte globulin/Cyclophosphamide/Methylprednisolone
C11629	Anti-Thymocyte-Globulin_Melphalan_Methylprednisolone	Chemotherapy_Regimen	Anti-thymocyte globulin/melphalan/methylprednisolone
C11630	Irinotecan_Vincristine	Chemotherapy_Regimen	Irinotecan/Vincristine
C11631	Rituximab_Vinorelbine	Chemotherapy_Regimen	Rituximab/Vinorelbine
C11632	Cisplatin_Dexrazoxane_Doxorubicin	Chemotherapy_Regimen	Cisplatin/Dexrazoxane/Doxorubicin
C11633	Dexrazoxane_Doxorubicin_Ifosfamide	Chemotherapy_Regimen	Dexrazoxane/Doxorubicin/Ifosfamide
C11634	Doxorubicin_P-30-Protein	Chemotherapy_Regimen	Doxorubicin/P-30 Protein
C11635	Capecitabine_Oxaliplatin	Chemotherapy_Regimen	Capecitabine/Oxaliplatin
C11636	Fluorouracil_Vincristine	Chemotherapy_Regimen	Fluorouracil/Vincristine
C11637	Carboplatin_Paclitaxel_Thalidomide	Chemotherapy_Regimen	Carboplatin/Paclitaxel/Thalidomide
C11638	Bleomycin_Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Procarbazine_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Doxorubicin/Etoposide/Prednisone/Procarbazine/Vincristine|BEACOPP
C11639	Autologous-Tumor-Cell-Vaccine_Sargramostim	Chemotherapy_Regimen	Autologous Tumor Cell Vaccine/Sargramostim
C11640	Cisplatin_Fluorouracil_Gemcitabine	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Gemcitabine
C11641	Tamoxifen_Trastuzumab	Chemotherapy_Regimen	Tamoxifen/Trastuzumab
C11642	Fludarabine_UCN-01	Chemotherapy_Regimen	Fludarabine/UCN-01
C11643	Irinotecan_Trastuzumab	Chemotherapy_Regimen	Irinotecan/Trastuzumab
C11644	MAGE-3_SB-AS-2	Chemotherapy_Regimen	MAGE-3/SB AS-2
C11645	Bryostatin-1_Interleukin-2	Chemotherapy_Regimen	Bryostatin 1/Interleukin-2
C11646	Cyclophosphamide_Doxorubicin_Etoposide_Fludarabine_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Fludarabine/Prednisone/Vincristine
C11647	Anti-Thymocyte-Globulin_Thiotepa	Chemotherapy_Regimen	Anti-thymocyte globulin/thiotepa
C11648	Leflunomide_Mitoxantrone_Prednisone	Chemotherapy_Regimen	Leflunomide/Mitoxantrone/Prednisone
C11649	L-778-123_Paclitaxel	Chemotherapy_Regimen	L-778,123/Paclitaxel
C11650	Fluorouracil_UCN-01	Chemotherapy_Regimen	Fluorouracil/UCN-01
C11651	gp100-Antigen_Montanide-ISA-51_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Montanide ISA-51/Tyrosinase Peptide
C11652	gp100-Antigen_MART-1-Antigen_Montanide-ISA-51	Chemotherapy_Regimen	gp100 Antigen/MART-1 Antigen/Montanide ISA-51
C11653	gp100-Antigen_Interleukin-2_MART-1-Antigen_Montanide-ISA-51	Chemotherapy_Regimen	gp100 Antigen/Interleukin-2/MART-1 Antigen/Montanide ISA-51
C11654	MART-1-Antigen_Montanide-ISA-51	Chemotherapy_Regimen	MART-1 antigen/Montanide ISA-51
C11655	Montanide-ISA-51_Peptide-946-Melanoma-Vaccine	Chemotherapy_Regimen	Montanide ISA-51/Peptide 946 melanoma vaccine
C11656	Montanide-ISA-51_Peptide-946-Tetanus-Peptide-Conjugate-Melanoma-Vaccine	Chemotherapy_Regimen	Montanide ISA-51/Peptide 946-tetanus peptide conjugate melanoma vaccine
C11657	Docetaxel_Mitoxantrone	Chemotherapy_Regimen	Docetaxel/Mitoxantrone
C11658	Montanide-ISA-51_Peptide-946-Melanoma-Vaccine_Tetanus-Peptide-Melanoma-Vaccine	Chemotherapy_Regimen	Montanide ISA-51/Peptide 946 melanoma vaccine/Tetanus peptide melanoma vaccine
C11659	gp100-Antigen_HPV-16-E7_12-20_Peptide-Vaccine_Montanide-ISA-51	Chemotherapy_Regimen	gp100 Antigen/HPV-16 E7(12-20) Peptide Vaccine/Montanide ISA-51
C11660	Dexamethasone_Floxuridine_Leucovorin-Calcium_SCH-58500	Chemotherapy_Regimen	Dexamethasone/Floxuridine/Leucovorin Calcium/SCH-58500
C11661	gp100-Antigen_Interleukin-12_Montanide-ISA-51_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Interleukin-12/Montanide ISA-51/Tyrosinase Peptide
C11662	gp100-Antigen_Montanide-ISA-51_Sargramostim_Tetanus-Peptide-Melanoma-Vaccine_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Montanide ISA-51/Sargramostim/Tetanus Peptide Melanoma Vaccine/Tyrosinase Peptide
C11663	Montanide-ISA-51_von-Hippel-Lindau-Peptide-Vaccine	Chemotherapy_Regimen	Montanide ISA-51/von Hippel-Lindau peptide vaccine
C11664	Interleukin-2_Montanide-ISA-51_Von-Hippel-Lindau-Peptide-Vaccine	Chemotherapy_Regimen	Interleukin-2/Montanide ISA-51/Von Hippel-Lindau Peptide Vaccine
C11665	Montanide-ISA-51_Sargramostim_von-Hippel-Lindau-Peptide-Vaccine	Chemotherapy_Regimen	Montanide ISA-51/Sargramostim/von Hippel-Lindau peptide vaccine
C11666	gp100-Antigen_Interleukin-2_Montanide-ISA-51	Chemotherapy_Regimen	gp100 Antigen/Interleukin-2/Montanide ISA-51
C11667	Cyclosporine_Irinotecan_Phenobarbital	Chemotherapy_Regimen	Cyclosporine/Irinotecan/Phenobarbital
C11668	gp100-Antigen_Montanide-ISA-51	Chemotherapy_Regimen	gp100 Antigen/Montanide ISA-51
C11669	Montanide-ISA-51_Tyrosinase-Peptide	Chemotherapy_Regimen	Montanide ISA-51/Tyrosinase peptide
C11670	Interleukin-2_Montanide-ISA-51_Tyrosinase-Peptide	Chemotherapy_Regimen	Interleukin-2/Montanide ISA-51/Tyrosinase Peptide
C11671	Interleukin-12_Montanide-ISA-51_Tyrosinase-Peptide	Chemotherapy_Regimen	Interleukin-12/Montanide ISA-51/Tyrosinase Peptide
C11672	Montanide-ISA-51_Sargramostim_Tyrosinase-Peptide	Chemotherapy_Regimen	Montanide ISA-51/Sargramostim/Tyrosinase peptide
C11673	gp100-Antigen_Interleukin-12_Montanide-ISA-51	Chemotherapy_Regimen	gp100 Antigen/Interleukin-12/Montanide ISA-51
C11674	gp100-Antigen_Montanide-ISA-51_Sargramostim	Chemotherapy_Regimen	gp100 Antigen/Montanide ISA-51/Sargramostim
C11675	Montanide-ISA-51_Tyrosinase-Related-Protein-1	Chemotherapy_Regimen	Montanide ISA-51/Tyrosinase-Related Protein-1
C11676	Interleukin-2_Montanide-ISA-51_Tyrosinase-Related-Protein-1	Chemotherapy_Regimen	Interleukin-2/Montanide ISA-51/Tyrosinase-Related Protein-1
C11677	Interleukin-12_Montanide-ISA-51_Tyrosinase-Related-Protein-1	Chemotherapy_Regimen	Interleukin-12/Montanide ISA-51/Tyrosinase Related Protein-1
C11678	Montanide-ISA-51_Sargramostim_Tyrosinase-Related-Protein-1	Chemotherapy_Regimen	Montanide ISA-51/Sargramostim/Tyrosinase-Related Protein-1
C11679	gp100-Antigen_MART-1-Antigen_Montanide-ISA-51_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/MART-1 Antigen/Montanide ISA-51/Tyrosinase Peptide
C11680	gp100-Antigen_Interleukin-2_MART-1-Antigen_Montanide-ISA-51_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Interleukin-2/MART-1 Antigen/Montanide ISA-51/Tyrosinase Peptide
C11681	gp100-Antigen_MART-1-Antigen_Montanide-ISA-51_Sargramostim_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/MART-1 Antigen/Montanide ISA-51/Sargramostim/Tyrosinase Peptide
C11682	Flt3-Ligand_gp100-Antigen_MART-1-Antigen_Montanide-ISA-51_Tyrosinase-Peptide	Chemotherapy_Regimen	Flt3 Ligand/gp100 Antigen/MART-1 Antigen/Montanide ISA-51/Tyrosinase Peptide
C11683	CRL-1005_gp100-Antigen_Montanide-ISA-51_Tyrosinase-Peptide	Chemotherapy_Regimen	CRL 1005/gp100 Antigen/Montanide ISA-51/Tyrosinase Peptide
C11684	gp100-Antigen_Montanide-ISA-51_Sargramostim_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Montanide ISA-51/Sargramostim/Tyrosinase Peptide
C11685	Interleukin-12_MART-1-Antigen_Montanide-ISA-51	Chemotherapy_Regimen	Interleukin-12/MART-1 Antigen/Montanide ISA-51
C11686	HER-2-neu-Peptide-Vaccine_Montanide-ISA-51	Chemotherapy_Regimen	HER-2-neu peptide vaccine/Montanide ISA-51
C11687	Bcr-Abl-Peptide-Vaccine_QS21	Chemotherapy_Regimen	Bcr-Abl Peptide Vaccine/QS21
C11688	E7_86-93_LipoPeptide_HPV-16-E7_12-20_Peptide-Vaccine_Montanide-ISA-51	Chemotherapy_Regimen	E7(86-93) Lipopeptide/HPV-16 E7(12-20) Peptide Vaccine/Montanide ISA-51
C11689	Mutant-P53-Peptide-Pulsed-Dendritic-Cell-Vaccine_Sargramostim	Chemotherapy_Regimen	Mutant p53 peptide pulsed dendritic cell vaccine/Sargramostim
C11690	Montanide-ISA-51_p53-Peptide-Vaccine_Sargramostim	Chemotherapy_Regimen	Montanide ISA-51/p53 peptide vaccine/Sargramostim
C11691	gp100-Antigen_MART-1-Antigen_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/MART-1 Antigen/Tyrosinase Peptide
C11692	Carboplatin_Vinorelbine	Chemotherapy_Regimen	Carboplatin/Vinorelbine
C11693	Fluorouracil_Gemcitabine_Paclitaxel	Chemotherapy_Regimen	Fluorouracil/Gemcitabine/Paclitaxel
C11694	Adenovirus_CD40-ligand	Retired_Concepts	Adenovirus/CD40-ligand
C11695	gp100-Antigen_Tetanus-Peptide-Melanoma-Vaccine_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Tetanus Peptide Melanoma Vaccine/Tyrosinase Peptide
C11696	Carboplatin_Docetaxel_Gemcitabine	Chemotherapy_Regimen	Carboplatin/Docetaxel/Gemcitabine
C11697	Estramustine_Paclitaxel_Vinorelbine	Chemotherapy_Regimen	Estramustine/Paclitaxel/Vinorelbine
C11698	Oxaliplatin_Paclitaxel	Chemotherapy_Regimen	Oxaliplatin/Paclitaxel
C11699	Bicalutamide_Goserelin_Mitoxantrone_Prednisone	Chemotherapy_Regimen	Bicalutamide/Goserelin/Mitoxantrone/Prednisone
C11700	Autologous-Tumor-Cell-Vaccine_Keyhole-Limpet-Hemocyanin_Sargramostim	Chemotherapy_Regimen	Autologous Tumor Cell Vaccine/Keyhole Limpet Hemocyanin/Sargramostim
C11701	Interleukin-2_Vaccine-Sensitized-Draining-Lymph-Node-Cells	Chemotherapy_Regimen	Interleukin-2/Vaccine-Sensitized Draining Lymph Node Cells
C11702	HER-2-Neu-Peptide-Vaccine_Sargramostim	Chemotherapy_Regimen	HER-2-Neu Peptide Vaccine/Sargramostim
C11703	Rituximab_Y-90-ibritumomab-tiuxetan	Chemotherapy_Regimen	Rituximab/Yttrium Y 90 ibritumomab tiuxetan
C11704	LY335979_Vinorelbine	Chemotherapy_Regimen	LY335979/Vinorelbine
C11705	gp100-Antigen_Interleukin-2_Montanide-ISA-51_Tumor-Infiltrating-Lymphocytes	Chemotherapy_Regimen	gp100 Antigen/Interleukin-2/Montanide ISA-51/Tumor Infiltrating Lymphocytes
C11706	BCG_Polyvalent-Melanoma-Vaccine	Chemotherapy_Regimen	BCG/Polyvalent Melanoma Vaccine
C11707	Cisplatin_Cytarabine_Etoposide_Ifosfamide_Yttrium-Y-90-Humanized-Epratuzumab	Chemotherapy_Regimen	Cisplatin/Cytarabine/Etoposide/Ifosfamide/Yttrium Y 90 Humanized Epratuzumab
C11708	Filgrastim_Interleukin-11	Chemotherapy_Regimen	Filgrastim/Interleukin-11
C11709	Keyhole-limpet-hemocyanin_MUC-1-Antigen_QS21	Chemotherapy_Regimen	Keyhole Limpet Hemocyanin/MUC-1 Antigen/QS21
C11710	BCG_Interferon-alfa	Chemotherapy_Regimen	BCG/Interferon alfa
C11711	Bryostatin-1_Gemcitabine	Chemotherapy_Regimen	Bryostatin 1/Gemcitabine
C11712	Carboplatin_Ifosfamide_Thiotepa	Chemotherapy_Regimen	Carboplatin/Ifosfamide/Thiotepa
C11713	Doxorubicin-Hcl-Liposome_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Doxorubicin Hcl Liposome/Methotrexate/Prednisone/Vincristine
C11714	Cyclophosphamide_Cytarabine_Fludarabine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Fludarabine
C11715	Asparaginase_Dexamethasone	Chemotherapy_Regimen	Asparaginase/Dexamethasone
C11716	Dexamethasone_Methotrexate_Vincristine	Chemotherapy_Regimen	Dexamethasone/Methotrexate/Vincristine
C11717	Daunorubicin_Vincristine	Chemotherapy_Regimen	Daunorubicin/Vincristine
C11718	Prinomastat_Temozolomide	Chemotherapy_Regimen	Prinomastat/Temozolomide
C11719	Cisplatin_Gemcitabine_Prinomastat	Chemotherapy_Regimen	Cisplatin/Gemcitabine/Prinomastat
C11720	Gemcitabine_Oxaliplatin	Chemotherapy_Regimen	Gemcitabine/Oxaliplatin
C11721	Cisplatin_Rebeccamycin-Analogue	Chemotherapy_Regimen	Cisplatin/Rebeccamycin Analogue
C11722	Alum-Adjuvant_Monoclonal-Antibody-4B5-Anti-Idiotype-Vaccine	Chemotherapy_Regimen	Alum adjuvant/Monoclonal antibody 4B5 anti-idiotype vaccine
C11723	Monoclonal-antibody-4B5-anti-idiotype-Vaccine_Sargramostim	Chemotherapy_Regimen	Monoclonal antibody 4B5 anti-idiotype vaccine/Sargramostim
C11724	Anti-Thymocyte-Globulin_Cyclosporine	Chemotherapy_Regimen	Anti-thymocyte globulin/Cyclosporine
C11725	Fluorouracil_Leucovorin-Calcium_Triacetyluridine	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Triacetyluridine
C11726	Cytarabine_Leucovorin-Calcium	Chemotherapy_Regimen	Cytarabine/Leucovorin Calcium
C11727	Cytarabine_Daunorubicin_PSC-833	Chemotherapy_Regimen	Cytarabine/Daunorubicin/PSC 833
C11728	Tamoxifen_Tretinoin	Chemotherapy_Regimen	Tamoxifen/Tretinoin
C11729	Asparaginase_cyclophosphamide_cytarabine_daunorubicin_dexamethasone_methotrexate_thioguanine_vincristine	Chemotherapy_Regimen	Asparaginase/cyclophosphamide/cytarabine/daunorubicin/dexamethasone/methotrexate/thioguanine/vincristine
C11730	Asparaginase_cyclophosphamide_cytarabine_daunorubicin_methotrexate_prednisone_vincristine	Chemotherapy_Regimen	Asparaginase/cyclophosphamide/cytarabine/daunorubicin/methotrexate/prednisone/vincristine
C11731	Cyclophosphamide_Cytarabine_Mercaptopurine_Methotrexate_Prednisone	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Mercaptopurine/Methotrexate/Prednisone
C11732	Asparaginase_cytarabine_daunorubicin_methotrexate_prednisone_vincristine	Chemotherapy_Regimen	Asparaginase/cytarabine/daunorubicin/methotrexate/prednisone/vincristine
C11733	Docetaxel_Oxaliplatin	Chemotherapy_Regimen	Docetaxel/Oxaliplatin
C11734	Amifostine_Cisplatin_Docetaxel	Chemotherapy_Regimen	Amifostine/Cisplatin/Docetaxel
C11735	Keyhole-limpet-hemocyanin_polysialic-Acid	Chemotherapy_Regimen	Keyhole Limpet Hemocyanin/Polysialic Acid
C11736	Keyhole-limpet-hemocyanin_polysialic-Acid_QS21	Chemotherapy_Regimen	Keyhole Limpet Hemocyanin/Polysialic Acid/QS21
C11737	Exemestane_Raloxifene	Chemotherapy_Regimen	Exemestane/Raloxifene
C11738	Cytarabine_UCN-01	Chemotherapy_Regimen	Cytarabine/UCN-01
C11739	Interleukin-12_Rituximab	Chemotherapy_Regimen	Interleukin-12/Rituximab
C11740	Fluorouracil_Gemcitabine_Oxaliplatin	Chemotherapy_Regimen	Fluorouracil/Gemcitabine/Oxaliplatin
C11741	Dactinomycin_Melphalan	Chemotherapy_Regimen	Dactinomycin/Melphalan
C11742	Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Rituximab_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Prednisone/Rituximab/Vincristine
C11743	Irinotecan_Oblimersen	Chemotherapy_Regimen	Irinotecan/Oblimersen
C11744	Doxorubicin-HCl-Liposome_Trastuzumab	Chemotherapy_Regimen	Doxorubicin HCl Liposome/Trastuzumab
C11745	Amifostine_Cisplatin_Irinotecan	Chemotherapy_Regimen	Amifostine/Cisplatin/Irinotecan
C11746	Docetaxel_Thalidomide	Chemotherapy_Regimen	Docetaxel/Thalidomide
C11747	Cisplatin_Raltitrexed	Chemotherapy_Regimen	Cisplatin/Raltitrexed
C11748	Carboplatin_Epirubicin_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Epirubicin/Paclitaxel
C11749	Cytarabine_Fludarabine_Oblimersen	Chemotherapy_Regimen	Cytarabine/Fludarabine/Oblimersen
C11750	Docetaxel_MS-209	Chemotherapy_Regimen	Docetaxel/MS-209
C11751	MUC-2-KLH-Vaccine_QS21	Chemotherapy_Regimen	MUC-2-KLH Vaccine/QS21
C11752	O6-Benzylguanine_Polifeprosan-20-With-Carmustine-Implant	Chemotherapy_Regimen	O6-Benzylguanine/Polifeprosan 20 With Carmustine Implant
C11753	Ifosfamide_Paclitaxel_Teniposide	Chemotherapy_Regimen	Ifosfamide/Paclitaxel/Teniposide
C11754	Docetaxel_Doxorubicin-Hcl-Liposome_Trastuzumab	Chemotherapy_Regimen	Docetaxel/Doxorubicin Hcl Liposome/Trastuzumab
C11755	Vinorelbine_XR9576	Chemotherapy_Regimen	Vinorelbine/XR9576
C11756	Montanide-ISA-51_PR1-Leukemia-Peptide-Vaccine_Sargramostim	Chemotherapy_Regimen	Montanide ISA-51/PR1 leukemia peptide vaccine/Sargramostim
C11757	Biomed-101_Interleukin-2	Chemotherapy_Regimen	Biomed 101/Interleukin-2
C11758	Anti-Thymocyte-Globulin_Methylprednisolone_Tacrolimus	Chemotherapy_Regimen	Anti-thymocyte globulin/methylprednisolone/tacrolimus
C11759	CI-994_Gemcitabine	Chemotherapy_Regimen	CI-994/Gemcitabine
C11760	Eniluracil_Fluorouracil_Oxaliplatin	Chemotherapy_Regimen	Eniluracil/Fluorouracil/Oxaliplatin
C11761	Cisplatin_Tirapazamine_Vinorelbine	Chemotherapy_Regimen	Cisplatin/Tirapazamine/Vinorelbine
C11762	Cetuximab_Irinotecan	Chemotherapy_Regimen	Cetuximab/Irinotecan
C11763	Cisplatin_Cyclophosphamide_Etoposide_Mafosfamide_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Etoposide/Mafosfamide/Vincristine
C11764	Fluorouracil_irinotecan_leucovorin-calcium_oxaliplatin	Chemotherapy_Regimen	Fluorouracil/irinotecan/leucovorin calcium/oxaliplatin
C11765	Carboplatin_Paclitaxel_Tirapazamine	Chemotherapy_Regimen	Carboplatin/Paclitaxel/Tirapazamine
C11766	Docetaxel_Methotrexate	Chemotherapy_Regimen	Docetaxel/Methotrexate
C11767	Oblimersen_Paclitaxel	Chemotherapy_Regimen	Oblimersen/Paclitaxel
C11768	Cetuximab_Gemcitabine	Chemotherapy_Regimen	Cetuximab/Gemcitabine
C11769	Carboplatin_Etoposide_Topotecan	Chemotherapy_Regimen	Carboplatin/Etoposide/Topotecan
C11770	Carboplatin_Etoposide_Ifosfamide_Rituximab	Chemotherapy_Regimen	Carboplatin/Etoposide/Ifosfamide/Rituximab
C11771	Asparaginase_cyclophosphamide_cytarabine_daunorubicin_thioguanine	Chemotherapy_Regimen	Asparaginase/cyclophosphamide/cytarabine/daunorubicin/thioguanine
C11772	Asparaginase_cyclophosphamide_cytarabine_daunorubicin_dexamethasone_leucovorin-calcium_mercaptopurine_methotrexate_thioguanine_vincristine	Chemotherapy_Regimen	Asparaginase/cyclophosphamide/cytarabine/daunorubicin/dexamethasone/leucovorin calcium/mercaptopurine/methotrexate/thioguanine/vincristine
C11773	Interleukin-2_Interleukin-12	Chemotherapy_Regimen	Interleukin-2/interleukin-12
C11774	Carboplatin_Docetaxel_Estramustine	Chemotherapy_Regimen	Carboplatin/Docetaxel/Estramustine
C11775	Capecitabine_Paclitaxel	Chemotherapy_Regimen	Capecitabine/Paclitaxel
C11776	Cisplatin_Cytarabine_Dexamethasone_Rituximab	Chemotherapy_Regimen	Cisplatin/Cytarabine/Dexamethasone/Rituximab
C11777	Amifostine_Azacitidine	Chemotherapy_Regimen	Amifostine/Azacitidine
C11778	Paclitaxel_SU5416	Chemotherapy_Regimen	Paclitaxel/SU5416
C11779	Carboplatin_Fludarabine	Chemotherapy_Regimen	Carboplatin/Fludarabine
C11780	AFP-Gene-Hepatocellular-Carcinoma-Vaccine_Montanide-ISA-51	Chemotherapy_Regimen	AFP Gene Hepatocellular Carcinoma Vaccine/Montanide ISA-51
C11781	RAS-Peptide-Cancer-Vaccine_Sargramostim	Chemotherapy_Regimen	RAS Peptide Cancer Vaccine/Sargramostim
C11782	Azacitidine_Phenylbutyrate	Chemotherapy_Regimen	Azacitidine/Phenylbutyrate
C11783	gp209-2M-Antigen_Heat-Shock-Protein-70_OVA-Bip-Peptide_Tyrosinase-Peptide	Chemotherapy_Regimen	gp209-2M Antigen/Heat Shock Protein 70/OVA Bip Peptide/Tyrosinase Peptide
C11784	Carboplatin_Paclitaxel_ZD-1839	Chemotherapy_Regimen	Carboplatin/Paclitaxel/ZD 1839
C11785	Filgrastim_Flt3-Ligand_Milodistim_Sargramostim	Chemotherapy_Regimen	Filgrastim/Flt3 Ligand/Milodistim/Sargramostim
C11786	BiSpecific-Antibody-MDX447_Lymphokine-Activated-Killer-Cells	Chemotherapy_Regimen	Bispecific Antibody MDX447/Lymphokine-Activated Killer Cells
C11787	Doxorubicin_SU5416	Chemotherapy_Regimen	Doxorubicin/SU5416
C11788	Carmustine_RSR13	Chemotherapy_Regimen	Carmustine/RSR13
C11789	Estramustine_Mitoxantrone_Vinorelbine	Chemotherapy_Regimen	Estramustine/Mitoxantrone/Vinorelbine
C11790	Interferon-Alfa_Isotretinoin_Paclitaxel	Chemotherapy_Regimen	Interferon Alfa/Isotretinoin/Paclitaxel
C11791	Cisplatin_Fluorouracil_Irinotecan	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Irinotecan
C11792	Etoposide-Phosphate_Melphalan_Topotecan	Chemotherapy_Regimen	Etoposide Phosphate/Melphalan/Topotecan
C11793	Cytarabine_Daunorubicin_Etoposide_Topotecan	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Etoposide/Topotecan
C11794	Cisplatin_Mitomycin_Tretinoin_Vinorelbine	Chemotherapy_Regimen	Cisplatin/Mitomycin/Tretinoin/Vinorelbine
C11795	Cisplatin_Tretinoin_Vinorelbine	Chemotherapy_Regimen	Cisplatin/Tretinoin/Vinorelbine
C11796	Cisplatin_Fenretinide_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Fenretinide/Paclitaxel
C11797	Cisplatin_Cyclophosphamide_Dexamethasone_Etoposide_Thalidomide	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Dexamethasone/Etoposide/Thalidomide	A chemotherapy combination used in the treatment of cancers such as multiple myeloma and consisting of dexamethasone (antiinflammatory), cisplatin, Dexamethasone, cyclophosphamide, etoposide (cytostatic) and thalidomide (antiangiogenic). (NCI04)
C11798	Carboplatin_Paclitaxel_Shark-Cartilage	Chemotherapy_Regimen	Carboplatin/Paclitaxel/Shark Cartilage
C11799	Cisplatin_Shark-Cartilage_Vinorelbine	Chemotherapy_Regimen	Cisplatin/Shark Cartilage/Vinorelbine
C11800	Docetaxel_Trastuzumab	Chemotherapy_Regimen	Docetaxel/Trastuzumab
C11801	Cytarabine_Daunorubicin_Etoposide_Tretinoin	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Etoposide/Tretinoin
C11802	Cytarabine_Filgrastim_Fludarabine	Chemotherapy_Regimen	Cytarabine/Filgrastim/Fludarabine
C11803	Cytarabine_Fludarabine_Tretinoin	Chemotherapy_Regimen	Cytarabine/Fludarabine/Tretinoin
C11804	Carboplatin_Gemcitabine_Paclitaxel_Trastuzumab	Chemotherapy_Regimen	Carboplatin/Gemcitabine/Paclitaxel/Trastuzumab
C11805	Temozolomide_Thalidomide	Chemotherapy_Regimen	Temozolomide/Thalidomide
C11806	Filgrastim-Fetal-Liver-Tyrosine-Kinase-3-Fusion-Protein_gp100-Antigen_MART-1-Antigen_Montanide-ISA-51_Tyrosinase-Peptide	Chemotherapy_Regimen	Filgrastim-Fetal Liver Tyrosine Kinase-3 Fusion Protein/gp100 Antigen/MART-1 Antigen/Montanide ISA-51/Tyrosinase Peptide
C11807	Bleomycin_Cyclophosphamide_Etoposide_Mitoxantrone_Prednisolone_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Etoposide/Mitoxantrone/Prednisolone/Vincristine
C11808	Eflornithine_Sulindac	Chemotherapy_Regimen	Eflornithine/Sulindac
C11809	Celecoxib_Selenium	Chemotherapy_Regimen	Celecoxib/Selenium
C11810	O6-benzylguanine_Temozolomide	Chemotherapy_Regimen	O6-benzylguanine/Temozolomide
C11811	Irinotecan_SU5416	Chemotherapy_Regimen	Irinotecan/SU5416
C11812	Cyclosporine_Filgrastim_Methylprednisolone_Monoclonal-Antibody-Okt3	Chemotherapy_Regimen	Cyclosporine/Filgrastim/Methylprednisolone/Monoclonal Antibody Okt3
C11813	Floxuridine_Leucovorin-Calcium_Oxaliplatin	Chemotherapy_Regimen	Floxuridine/Leucovorin Calcium/Oxaliplatin
C11814	R115777_Trastuzumab	Chemotherapy_Regimen	R115777/Trastuzumab
C11815	Interleukin-2_Staphylococcal-Enterotoxin-B	Chemotherapy_Regimen	Interleukin-2/Staphylococcal Enterotoxin B
C11816	Cisplatin_Lurtotecan-Liposome	Chemotherapy_Regimen	Cisplatin/Lurtotecan Liposome
C11817	Cyclophosphamide_Dexamethasone_Mitoxantrone	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Mitoxantrone
C11818	Cisplatin_Gemcitabine_ZD-1839	Chemotherapy_Regimen	Cisplatin/Gemcitabine/ZD 1839
C11819	Cyclophosphamide_Cytarabine_Dexamethasone_Mitoxantrone	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Dexamethasone/Mitoxantrone
C11820	Irinotecan_Temozolomide	Chemotherapy_Regimen	Irinotecan/Temozolomide
C11821	Anti-Human-Chorionic-Gonadotropin-Vaccine_Gemcitabine	Chemotherapy_Regimen	Anti-human chorionic gonadotropin vaccine/Gemcitabine
C11822	Carboplatin_Pyrazoloacridine	Chemotherapy_Regimen	Carboplatin/Pyrazoloacridine
C11823	Leucovorin-Calcium_Methotrexate	Chemotherapy_Regimen	Leucovorin Calcium/Methotrexate
C11824	Cisplatin_Irinotecan_SU5416	Chemotherapy_Regimen	Cisplatin/Irinotecan/SU5416
C11825	Interleukin-2_Stem-Cell-Factor	Chemotherapy_Regimen	Interleukin-2/Stem Cell Factor
C11826	Fluorouracil_Leucovorin-Calcium_Oxaliplatin_Trastuzumab	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Oxaliplatin/Trastuzumab
C11827	Dexamethasone_SU5416	Chemotherapy_Regimen	Dexamethasone/SU5416
C11828	Gemcitabine_Pemetrexed-Disodium	Chemotherapy_Regimen	Gemcitabine/Pemetrexed Disodium
C11829	Arsenic-Trioxide_Ascorbic-Acid	Chemotherapy_Regimen	Arsenic trioxide/Ascorbic acid
C11830	Doxorubicin_Methotrexate_Pegaspargase_Vincristine	Chemotherapy_Regimen	Doxorubicin/Methotrexate/Pegaspargase/Vincristine
C11831	Cyclophosphamide_Methotrexate_Pegaspargase_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Methotrexate/Pegaspargase/Vincristine
C11832	Daunorubicin_dexamethasone_methotrexate_vincristine	Chemotherapy_Regimen	Daunorubicin/dexamethasone/methotrexate/vincristine
C11833	Gemcitabine_SU5416	Chemotherapy_Regimen	Gemcitabine/SU5416
C11834	Cytarabine_Dexamethasone_Leucovorin-Calcium_Methotrexate	Chemotherapy_Regimen	Cytarabine/Dexamethasone/Leucovorin Calcium/Methotrexate
C11835	Dexamethasone_Etoposide_Ifosfamide	Chemotherapy_Regimen	Dexamethasone/Etoposide/Ifosfamide
C11836	Daunorubicin-Liposomal_SU5416	Chemotherapy_Regimen	Daunorubicin Liposomal/SU5416
C11837	Interferon-Alfa_Thalidomide	Chemotherapy_Regimen	Interferon Alfa/Thalidomide
C11838	R115777_Topotecan	Chemotherapy_Regimen	R115777/Topotecan
C11839	Doxorubicin-Hcl-Liposome_Gemcitabine_Vinorelbine	Chemotherapy_Regimen	Doxorubicin Hcl Liposome/Gemcitabine/Vinorelbine
C11840	Lomustine_Temozolomide	Chemotherapy_Regimen	Lomustine/Temozolomide
C11841	Fluorouracil_IM-862	Chemotherapy_Regimen	Fluorouracil/IM-862
C11842	IM-862_Irinotecan	Chemotherapy_Regimen	IM-862/Irinotecan
C11843	Etoposide_Nitrocamptothecin	Chemotherapy_Regimen	Etoposide/Nitrocamptothecin
C11844	Cytarabine_Etoposide_Mitoxantrone_Monoclonal-Antibody-Hug1-M195	Chemotherapy_Regimen	Cytarabine/Etoposide/Mitoxantrone/Monoclonal Antibody Hug1-M195
C11845	MUC-1-KLH-Vaccine_QS21	Chemotherapy_Regimen	MUC-1 KLH Vaccine/QS21
C11846	Filgrastim_Mycophenolate-Mofetil_Tacrolimus	Chemotherapy_Regimen	Filgrastim/Mycophenolate Mofetil/Tacrolimus
C11847	BMS-214662_Paclitaxel	Chemotherapy_Regimen	BMS-214662/Paclitaxel
C11848	Cytarabine_Gemtuzumab-Ozogamicin	Chemotherapy_Regimen	Cytarabine/Gemtuzumab Ozogamicin
C11849	Cytarabine_Daunorubicin-Liposomal	Chemotherapy_Regimen	Cytarabine/Daunorubicin Liposomal
C11850	Cyclophosphamide_Cytarabine_Topotecan	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Topotecan
C11851	Doxorubicin-Hcl-Liposome_Gemcitabine	Chemotherapy_Regimen	Doxorubicin Hcl Liposome/Gemcitabine
C11852	gp209-2M-Antigen_Interleukin-2_Montanide-ISA-51	Chemotherapy_Regimen	gp209-2M Antigen/Interleukin-2/Montanide ISA-51
C11853	Cisplatin_Gemcitabine_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Gemcitabine/Paclitaxel
C11854	BMS-188797_Carboplatin	Chemotherapy_Regimen	BMS-188797/Carboplatin
C11855	Autologous-Dendritic-Cells_Candida-Albicans-Skin-Test-Reagent_CD40-Ligand_gp100-Antigen_Interferon-Gamma_Interleukin-4_MART-1-Antigen_Sargramostim_Tyrosinase-Peptide	Chemotherapy_Regimen	Autologous Dendritic Cells/Candida Albicans Skin Test Reagent/CD40-Ligand/gp100 Antigen/Interferon Gamma/Interleukin-4/MART-1 Antigen/Sargramostim/Tyrosinase Peptide
C11856	Capecitabine_Paclitaxel_Trastuzumab	Chemotherapy_Regimen	Capecitabine/Paclitaxel/Trastuzumab
C11857	rV-B7-1-Vaccine_Vaccinia-Prostate-Specific-Antigen-Vaccine	Chemotherapy_Regimen	rV-B7.1 Vaccine/Vaccinia-Prostate-Specific-Antigen Vaccine
C11858	Dexamethasone_Idarubicin	Chemotherapy_Regimen	Dexamethasone/Idarubicin
C11859	Carboplatin_Temozolomide_Vincristine	Chemotherapy_Regimen	Carboplatin/Temozolomide/Vincristine
C11860	Arginine-Butyrate_Ganciclovir	Chemotherapy_Regimen	Arginine butyrate/Ganciclovir
C11861	Chlorambucil_Dexamethasone_Mitoxantrone	Chemotherapy_Regimen	Chlorambucil/Dexamethasone/Mitoxantrone
C11862	Irinotecan_Octreotide	Chemotherapy_Regimen	Irinotecan/Octreotide
C11863	DX-8951f_Gemcitabine	Chemotherapy_Regimen	DX-8951f/Gemcitabine
C11864	Docetaxel_Cyclophosphamide	Chemotherapy_Regimen	Docetaxel/Cyclophosphamide|Cyclophosphamide/Docetaxel
C11865	Interleukin-2_Trastuzumab	Chemotherapy_Regimen	Interleukin-2/Trastuzumab
C11866	MAGE-12-Peptide-Vaccine_Montanide-ISA-51	Chemotherapy_Regimen	MAGE-12 peptide vaccine/Montanide ISA-51
C11867	Interleukin-2_MAGE-12-Peptide-Vaccine_Montanide-ISA-51	Chemotherapy_Regimen	Interleukin-2/MAGE-12 Peptide Vaccine/Montanide ISA-51
C11868	Dexamethasone_Phenylbutyrate_Sargramostim	Chemotherapy_Regimen	Dexamethasone/Phenylbutyrate/Sargramostim
C11869	Interferon-Alfa_Lu-177-Monoclonal-Antibody-CC49_Paclitaxel	Chemotherapy_Regimen	Interferon Alfa/Lutetium Lu 177 Monoclonal Antibody CC49/Paclitaxel
C11870	Interferon-Alfa_Lu-177-Monoclonal-Antibody-CC49_Topotecan	Chemotherapy_Regimen	Interferon Alfa/Lutetium Lu 177 Monoclonal Antibody CC49/Topotecan
C11871	Interferon-Alfa_Paclitaxel_Yttrium-Y-90-Monoclonal-Antibody-CC49	Chemotherapy_Regimen	Interferon Alfa/Paclitaxel/Yttrium Y 90 Monoclonal Antibody CC49
C11872	BMS-275291_Carboplatin_Paclitaxel	Chemotherapy_Regimen	BMS-275291/Carboplatin/Paclitaxel
C11873	Arsenic-Trioxide_Tretinoin	Chemotherapy_Regimen	Arsenic trioxide/Tretinoin
C11874	Cisplatin_Cyclophosphamide_Etoposide_Methotrexate_Vincristine	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Etoposide/Methotrexate/Vincristine
C11875	Carboplatin_Doxorubicin-HCl-Liposome	Chemotherapy_Regimen	Carboplatin/Doxorubicin HCl Liposome
C11876	Ganciclovir_Interleukin-2_Zidovudine	Chemotherapy_Regimen	Ganciclovir/Interleukin-2/Zidovudine
C11877	Denileukin-Diftitox_Dexamethasone	Chemotherapy_Regimen	Denileukin Diftitox/Dexamethasone
C11878	QS21_RAS-Peptide-Cancer-Vaccine	Chemotherapy_Regimen	QS21/RAS peptide cancer vaccine
C11879	Interferon-Alfa_SU5416	Chemotherapy_Regimen	Interferon Alfa/SU5416
C11880	Celecoxib_Trastuzumab	Chemotherapy_Regimen	Celecoxib/Trastuzumab
C11881	Carboplatin_SU5416	Chemotherapy_Regimen	Carboplatin/SU5416
C11882	Donepezil_Vitamin-E	Chemotherapy_Regimen	Donepezil/Vitamin E
C11883	Oxaliplatin_Topotecan	Chemotherapy_Regimen	Oxaliplatin/Topotecan
C11884	Gemcitabine_SCH-66336	Chemotherapy_Regimen	Gemcitabine/SCH 66336
C11885	gp100-Antigen_Interferon-Alfa_MART-1-Antigen_Montanide-ISA-51_Sargramostim_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Interferon Alfa/MART-1 Antigen/Montanide ISA-51/Sargramostim/Tyrosinase Peptide
C11886	gp100-Antigen_Interferon-Alfa_MART-1-Antigen_Montanide-ISA-51_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Interferon Alfa/MART-1 Antigen/Montanide ISA-51/Tyrosinase Peptide
C11887	Hydrocortisone_Ketoconazole	Chemotherapy_Regimen	Hydrocortisone/Ketoconazole
C11888	Etoposide_Ifosfamide_Topotecan	Chemotherapy_Regimen	Etoposide/Ifosfamide/Topotecan
C11889	Fluorouracil_Irinotecan	Chemotherapy_Regimen	Fluorouracil/Irinotecan
C11890	Docetaxel_Oblimersen	Chemotherapy_Regimen	Docetaxel/Oblimersen
C11891	Cisplatin_Etoposide_Tirapazamine	Chemotherapy_Regimen	Cisplatin/Etoposide/Tirapazamine
C11892	Paclitaxel_Prinomastat	Chemotherapy_Regimen	Paclitaxel/Prinomastat
C11893	Carboplatin_Fluorouracil_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Fluorouracil/Paclitaxel
C11894	Gemcitabine_ISIS-2503	Chemotherapy_Regimen	Gemcitabine/ISIS 2503
C11895	Doxorubicin_Hydrocortisone_Methotrexate	Chemotherapy_Regimen	Doxorubicin/Hydrocortisone/Methotrexate
C11896	Cytarabine_Dexamethasone_Etoposide_Ifosfamide_Methotrexate_Vinblastine	Chemotherapy_Regimen	Cytarabine/Dexamethasone/Etoposide/Ifosfamide/Methotrexate/Vinblastine
C11897	Cyclophosphamide_Dexamethasone_Doxorubicin_Methotrexate_Vinblastine	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Doxorubicin/Methotrexate/Vinblastine
C11898	Autologous-Lymphocytes_Interleukin-2	Chemotherapy_Regimen	Autologous Lymphocytes/Interleukin-2
C11899	Capecitabine_Irinotecan_Oxaliplatin	Chemotherapy_Regimen	Capecitabine/Irinotecan/Oxaliplatin
C11900	Monoclonal-antibody-11D10-anti-idiotype-Vaccine_Monoclonal-antibody-3H1-anti-idiotype-Vaccine	Chemotherapy_Regimen	Monoclonal antibody 11D10 anti-idiotype vaccine/Monoclonal antibody 3H1 anti-idiotype vaccine
C11901	Bevacizumab_Thalidomide	Chemotherapy_Regimen	Bevacizumab/Thalidomide
C11902	Ascorbic-Acid_Selenium	Chemotherapy_Regimen	Ascorbic acid/Selenium
C11903	Ascorbic-Acid_Selenium_Vitamin-E	Chemotherapy_Regimen	Ascorbic acid/Selenium/Vitamin E
C11904	Flavopiridol_irinotecan	Chemotherapy_Regimen	Flavopiridol/irinotecan
C11905	Indium-In-111-Monoclonal-Antibody-Bre-3_Yttrium-Y-90-Monoclonal-Antibody-Bre-3	Chemotherapy_Regimen	Indium In 111 Monoclonal Antibody Bre-3/Yttrium Y 90 Monoclonal Antibody Bre-3
C11906	Amifostine_Carboplatin_Epirubicin_Paclitaxel	Chemotherapy_Regimen	Amifostine/Carboplatin/Epirubicin/Paclitaxel
C11907	Prednisone_Thalidomide	Chemotherapy_Regimen	Prednisone/Thalidomide
C11908	Cyclophosphamide_Doxorubicin_Iodine-I-131-Tositumomab_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Iodine I 131 Tositumomab/Prednisone/Vincristine
C11909	Bevacizumab_Fluorouracil_Irinotecan_Leucovorin-Calcium	Chemotherapy_Regimen	Bevacizumab/Fluorouracil/Irinotecan/Leucovorin Calcium
C11910	Fluorouracil_Leucovorin-Calcium_PS-341	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/PS-341
C11911	Carboplatin_Paclitaxel_Suramin	Chemotherapy_Regimen	Carboplatin/Paclitaxel/Suramin
C11912	Capecitabine_Cyclophosphamide_Epirubicin	Chemotherapy_Regimen	Capecitabine/Cyclophosphamide/Epirubicin
C11913	Doxorubicin_Octreotide	Chemotherapy_Regimen	Doxorubicin/Octreotide
C11914	Detox-B-Adjuvant_Verteporfin	Chemotherapy_Regimen	Detox-B Adjuvant/Verteporfin
C11915	MUC-1-Antigen_SB-AS-2	Chemotherapy_Regimen	MUC-1 Antigen/SB AS-2
C11916	Cyclosporine_Yttrium-Y-90-Monoclonal-Antibody-M170	Chemotherapy_Regimen	Cyclosporine/Yttrium Y 90 Monoclonal Antibody M170
C11917	Cyclosporine_Paclitaxel_Yttrium-Y-90-Monoclonal-Antibody-M170	Chemotherapy_Regimen	Cyclosporine/Paclitaxel/Yttrium Y 90 Monoclonal Antibody M170
C11918	Cyclosporine_Paclitaxel_Yttrium-Y-90-Monoclonal-Antibody-Lym-1	Chemotherapy_Regimen	Cyclosporine/Paclitaxel/Yttrium Y 90 Monoclonal Antibody Lym-1
C11919	Cyclosporine_Yttrium-Y-90-Monoclonal-Antibody-Lym-1	Chemotherapy_Regimen	Cyclosporine/Yttrium Y 90 Monoclonal Antibody Lym-1
C11920	Flavopiridol_Gemcitabine	Chemotherapy_Regimen	Flavopiridol/Gemcitabine
C11921	Dexamethasone_Floxuridine	Chemotherapy_Regimen	Dexamethasone/Floxuridine
C11922	Dexamethasone_Doxorubicin_Thalidomide	Chemotherapy_Regimen	Dexamethasone/Doxorubicin/Thalidomide
C11923	Filgrastim_Melphalan	Chemotherapy_Regimen	Filgrastim/Melphalan
C11924	Calcitriol_Carboplatin	Chemotherapy_Regimen	Calcitriol/Carboplatin
C11925	Cyclophosphamide_Doxorubicin_Etoposide_Rituximab_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Rituximab/Vincristine
C11926	Cyclosporine_Methylprednisolone_Mycophenolate-Mofetil	Chemotherapy_Regimen	Cyclosporine/Methylprednisolone/Mycophenolate Mofetil
C11927	Anti-Thymocyte-Globulin_Fludarabine_Melphalan	Chemotherapy_Regimen	Anti-thymocyte globulin/fludarabine/melphalan
C11928	Selenium_Vitamin-E	Chemotherapy_Regimen	Selenium/vitamin E
C11929	Imatinib-Mesylate_Interferon-Alfa	Chemotherapy_Regimen	Imatinib Mesylate/Interferon Alfa
C11930	Atamestane_Toremifene	Chemotherapy_Regimen	Atamestane/Toremifene
C11931	Exemestane_Goserelin	Chemotherapy_Regimen	Exemestane/Goserelin
C11932	Daunorubicin_Imatinib-Mesylate_Prednisone_Vincristine	Chemotherapy_Regimen	Daunorubicin/Imatinib Mesylate/Prednisone/Vincristine
C11933	DC-Chol-Liposomes_EGFR-Antisense-DNA	Chemotherapy_Regimen	DC-Chol Liposomes/EGFR Antisense DNA
C11934	Carboplatin_Irinotecan	Chemotherapy_Regimen	Carboplatin/Irinotecan
C11935	Calcitriol_Paclitaxel	Chemotherapy_Regimen	Calcitriol/Paclitaxel
C11936	Etoposide_Fluorouracil-Uracil_Leucovorin-Calcium	Chemotherapy_Regimen	Etoposide/Fluorouracil-Uracil/Leucovorin Calcium
C11937	Epirubicin_Tamoxifen	Chemotherapy_Regimen	Epirubicin/Tamoxifen
C11938	Docetaxel_Tamoxifen	Chemotherapy_Regimen	Docetaxel/Tamoxifen
C11939	Calcitriol_Dexamethasone	Chemotherapy_Regimen	Calcitriol/Dexamethasone
C11940	Fludarabine_Thalidomide	Chemotherapy_Regimen	Fludarabine/Thalidomide
C11941	Carboplatin_Etoposide-Phosphate_Ifosfamide	Chemotherapy_Regimen	Carboplatin/Etoposide Phosphate/Ifosfamide
C11942	Bevacizumab_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Bevacizumab/Fluorouracil/Leucovorin Calcium
C11943	Bevacizumab_Irinotecan	Chemotherapy_Regimen	Bevacizumab/Irinotecan
C11944	Autologous-Dendritic-Cells_Autologous-Tumor-Cell-Vaccine_Sargramostim	Chemotherapy_Regimen	Autologous Dendritic Cells/Autologous Tumor Cell Vaccine/Sargramostim
C11945	Bevacizumab_Capecitabine	Chemotherapy_Regimen	Bevacizumab/Capecitabine
C11946	Doxorubicin-Hcl-Liposome_Interleukin-12	Chemotherapy_Regimen	Doxorubicin Hcl Liposome/Interleukin-12
C11947	Cisplatin_UCN-01	Chemotherapy_Regimen	Cisplatin/UCN-01
C11948	Autologous-Tumor-Cell-Vaccine_Interleukin-2	Chemotherapy_Regimen	Autologous Tumor Cell Vaccine/Interleukin-2
C11949	Bryostatin-1_Sargramostim	Chemotherapy_Regimen	Bryostatin 1/Sargramostim
C11950	IDEC-In2B8_Rituximab_Yttrium-Y-90-Ibritumomab-Tiuxetan	Chemotherapy_Regimen	IDEC-In2B8/Rituximab/Yttrium Y 90 Ibritumomab Tiuxetan
C11951	Melphalan_Prednisone_Wobe-Mugos-E	Chemotherapy_Regimen	Melphalan/Prednisone/Wobe-Mugos E
C11952	Thalidomide_Topotecan	Chemotherapy_Regimen	Thalidomide/Topotecan
C11953	PEG-Interferon-Alfa-2b_Temozolomide	Chemotherapy_Regimen	PEG-Interferon Alfa-2b/Temozolomide|PEG-IFNA2b/TMZ
C11954	Sulindac_Thalidomide	Chemotherapy_Regimen	Sulindac/Thalidomide
C11955	Cisplatin_Dexamethasone_Gemcitabine	Chemotherapy_Regimen	Cisplatin/Dexamethasone/Gemcitabine
C11956	Carboplatin_Methotrexate_Vinblastine	Chemotherapy_Regimen	Carboplatin/Methotrexate/Vinblastine
C11957	Docetaxel_Filgrastim_XR9576	Chemotherapy_Regimen	Docetaxel/Filgrastim/XR9576
C11958	Doxorubicin_Filgrastim_XR9576	Chemotherapy_Regimen	Doxorubicin/Filgrastim/XR9576
C11959	Trastuzumab_Vinorelbine	Chemotherapy_Regimen	Trastuzumab/Vinorelbine
C11960	Topotecan_ZD9331	Chemotherapy_Regimen	Topotecan/ZD9331
C11961	Palivizumab_Ribavirin	Chemotherapy_Regimen	Palivizumab/Ribavirin
C11962	Docetaxel_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Docetaxel/Fluorouracil/Leucovorin Calcium
C11963	Detox-B-Adjuvant_RAS-Peptide-Cancer-Vaccine	Chemotherapy_Regimen	Detox-B Adjuvant/RAS Peptide Cancer Vaccine
C11964	Docetaxel_Filgrastim_Gemcitabine	Chemotherapy_Regimen	Docetaxel/Filgrastim/Gemcitabine
C11965	Bismuth-Bi213-Monoclonal-Antibody-M195_Cytarabine_Filgrastim	Chemotherapy_Regimen	Bismuth Bi213 Monoclonal Antibody M195/Cytarabine/Filgrastim
C11966	Autologous-Tumor-Cell-Vaccine_BCG	Chemotherapy_Regimen	Autologous Tumor Cell Vaccine/BCG
C11967	Dacarbazine_Oblimersen	Chemotherapy_Regimen	Dacarbazine/Oblimersen
C11968	_3-AP_Cisplatin_Paclitaxel	Chemotherapy_Regimen	3-AP/Cisplatin/Paclitaxel
C11969	GPI-0100_MUC-2-Globo-H-KLH-Conjugate-Vaccine	Chemotherapy_Regimen	GPI-0100/MUC-2-Globo H-KLH Conjugate Vaccine
C11970	Interleukin-12_PSA-Prostate-Cancer-Vaccine	Chemotherapy_Regimen	Interleukin-12/PSA Prostate Cancer Vaccine
C11971	Leucovorin-calcium_mercaptopurine_methotrexate_prednisolone_vincristine	Chemotherapy_Regimen	Leucovorin calcium/mercaptopurine/methotrexate/prednisolone/vincristine
C11972	Cytarabine_Daunorubicin_Dexamethasone_Prednisolone_Thioguanine_Vincristine	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Dexamethasone/Prednisolone/Thioguanine/Vincristine
C11973	Methotrexate_Prednisolone_Prednisone	Chemotherapy_Regimen	Methotrexate/Prednisolone/Prednisone
C11974	Asparaginase_cytarabine_daunorubicin_dexamethasone_methotrexate_prednisolone_vincristine	Chemotherapy_Regimen	Asparaginase/cytarabine/daunorubicin/dexamethasone/methotrexate/prednisolone/vincristine
C11975	Leucovorin-calcium_mercaptopurine_methotrexate_prednisolone	Chemotherapy_Regimen	Leucovorin calcium/mercaptopurine/methotrexate/prednisolone
C11976	Asparaginase_cytarabine_daunorubicin_dexamethasone_methotrexate_prednisolone_vindesine	Chemotherapy_Regimen	Asparaginase/cytarabine/daunorubicin/dexamethasone/methotrexate/prednisolone/vindesine
C11977	Cytarabine_Etoposide_Ifosfamide_Leucovorin-Calcium_Methotrexate_Prednisolone	Chemotherapy_Regimen	Cytarabine/Etoposide/Ifosfamide/Leucovorin Calcium/Methotrexate/Prednisolone
C11978	Cyclophosphamide_Dexrazoxane_Doxorubicin	Chemotherapy_Regimen	Cyclophosphamide/Dexrazoxane/Doxorubicin
C11979	_506U78_Mercaptopurine_Methotrexate	Chemotherapy_Regimen	506U78/Mercaptopurine/Methotrexate
C11980	CD40-Ligand_flt3-Ligand	Chemotherapy_Regimen	CD40-Ligand/flt3 Ligand
C11981	Interferon-Alfa_Lymphokine-Activated-Killer-Cells	Chemotherapy_Regimen	Interferon Alfa/Lymphokine-Activated Killer Cells
C11982	Doxorubicin-Hcl-Liposome_ZD0473	Chemotherapy_Regimen	Doxorubicin Hcl Liposome/ZD0473
C11983	Docetaxel_Flavopiridol	Chemotherapy_Regimen	Docetaxel/Flavopiridol|Docetaxel/flavopiridol
C11984	Bevacizumab_Docetaxel_Estramustine	Chemotherapy_Regimen	Bevacizumab/Docetaxel/Estramustine
C11985	Cisplatin_Gemcitabine_Trastuzumab	Chemotherapy_Regimen	Cisplatin/Gemcitabine/Trastuzumab
C11986	Dexamethasone_Ondansetron	Chemotherapy_Regimen	Dexamethasone/Ondansetron
C11987	Asparaginase_cytarabine_dexamethasone_vincristine	Chemotherapy_Regimen	Asparaginase/cytarabine/dexamethasone/vincristine
C11988	Asparaginase_cytarabine_prednisolone_vincristine	Chemotherapy_Regimen	Asparaginase/cytarabine/prednisolone/vincristine
C11989	Asparaginase_Doxorubicin_Methotrexate_Prednisolone_Vincristine	Chemotherapy_Regimen	Asparaginase/Doxorubicin/Methotrexate/Prednisolone/Vincristine
C11990	Asparaginase_cytarabine_daunorubicin_methotrexate_prednisolone_vincristine	Chemotherapy_Regimen	Asparaginase/cytarabine/daunorubicin/methotrexate/prednisolone/vincristine
C11991	Cyclophosphamide_Cytarabine_Mercaptopurine_Methotrexate_Prednisolone	Chemotherapy_Regimen	Cyclophosphamide/cytarabine/mercaptopurine/methotrexate/prednisolone
C11992	Cyclophosphamide_Cytarabine_Dexamethasone_Mercaptopurine_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Dexamethasone/Mercaptopurine/Methotrexate
C11993	Dexamethasone_Pegaspargase	Chemotherapy_Regimen	Dexamethasone/Pegaspargase
C11994	Keyhole-limpet-hemocyanin_Sargramostim	Chemotherapy_Regimen	Keyhole Limpet Hemocyanin/Sargramostim
C11995	Carboplatin_ISIS-3521_Paclitaxel	Chemotherapy_Regimen	Carboplatin/ISIS 3521/Paclitaxel
C11996	Carboplatin_IM-862_Paclitaxel	Chemotherapy_Regimen	Carboplatin/IM-862/Paclitaxel
C11997	Arsenic-Trioxide_Dexamethasone	Chemotherapy_Regimen	Arsenic trioxide/Dexamethasone
C11998	Epirubicin_Gemcitabine	Chemotherapy_Regimen	Epirubicin/Gemcitabine
C11999	Bevacizumab_Vinorelbine	Chemotherapy_Regimen	Bevacizumab/Vinorelbine
C12000	Carboplatin_Etoposide_Oblimersen	Chemotherapy_Regimen	Carboplatin/Etoposide/Oblimersen
C12001	Carmustine_Cytarabine_Dexamethasone_Etoposide_Melphalan	Chemotherapy_Regimen	Carmustine/Cytarabine/Dexamethasone/Etoposide/Melphalan
C12002	Carboplatin_Etoposide-Phosphate_Melphalan	Chemotherapy_Regimen	Carboplatin/Etoposide Phosphate/Melphalan
C12003	SU5416_Thalidomide	Chemotherapy_Regimen	SU5416/Thalidomide
C12004	Cisplatin_Epoetin-Alfa	Chemotherapy_Regimen	Cisplatin/Epoetin Alfa
C12005	Doxorubicin_Etoposide_Ifosfamide_Vincristine	Chemotherapy_Regimen	Doxorubicin/Etoposide/Ifosfamide/Vincristine
C12006	Cetuximab_Fluorouracil_Irinotecan_Leucovorin-Calcium	Chemotherapy_Regimen	Cetuximab/Fluorouracil/Irinotecan/Leucovorin Calcium
C12007	Monoclonal-antibody-Ch14-18_Sargramostim	Chemotherapy_Regimen	Monoclonal antibody Ch14.18/Sargramostim
C12008	Interleukin-2_Monoclonal-Antibody-Ch14-18	Chemotherapy_Regimen	Interleukin-2/Monoclonal Antibody Ch14.18
C12009	Carboplatin_Epirubicin	Chemotherapy_Regimen	Carboplatin/Epirubicin
C12010	Bevacizumab_Carboplatin_Paclitaxel	Chemotherapy_Regimen	Bevacizumab/Carboplatin/Paclitaxel
C12011	Dexamethasone_Isotretinoin	Chemotherapy_Regimen	Dexamethasone/Isotretinoin
C12012	Docetaxel_Exisulind	Chemotherapy_Regimen	Docetaxel/Exisulind
C12013	Epirubicin_Irinotecan	Chemotherapy_Regimen	Epirubicin/Irinotecan
C12014	Carboplatin_Squalamine-Lactate	Chemotherapy_Regimen	Carboplatin/Squalamine Lactate
C12015	Flutamide_Toremifene	Chemotherapy_Regimen	Flutamide/Toremifene
C12016	Cisplatin_Fluorouracil_G17DT	Chemotherapy_Regimen	Cisplatin/Fluorouracil/G17DT
C12017	Eflornithine_Triamcinolone	Chemotherapy_Regimen	Eflornithine/Triamcinolone
C12018	Autologous-Lymphocytes_Interleukin-2_Sargramostim	Chemotherapy_Regimen	Autologous Lymphocytes/Interleukin-2/Sargramostim
C12019	Fluorouracil_Irinotecan_Leucovorin-Calcium_SU5416	Chemotherapy_Regimen	Fluorouracil/Irinotecan/Leucovorin Calcium/SU5416
C12020	Cyclophosphamide_Doxorubicin_Leucovorin-Calcium_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Leucovorin Calcium/Methotrexate/Prednisone/Vincristine
C12021	Cyclophosphamide_Doxorubicin_Leucovorin-Calcium_Methotrexate_Prednisone_Rituximab_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Leucovorin Calcium/Methotrexate/Prednisone/Rituximab/Vincristine
C12022	Interleukin-2_Montanide-ISA-51_Telomerase_540-548-Peptide-Vaccine	Chemotherapy_Regimen	Interleukin-2/Montanide ISA-51/Telomerase: 540-548 Peptide Vaccine
C12023	Carboplatin_Docetaxel_Trastuzumab	Chemotherapy_Regimen	Carboplatin/Docetaxel/Trastuzumab
C12024	Cisplatin_Docetaxel_Trastuzumab	Chemotherapy_Regimen	Cisplatin/Docetaxel/Trastuzumab
C12025	Bevacizumab_Docetaxel_Doxorubicin	Chemotherapy_Regimen	Bevacizumab/Docetaxel/Doxorubicin
C12026	Carboplatin_Cisplatin-epinephrine_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Cisplatin-epinephrine/Paclitaxel
C12027	Anastrozole_Trastuzumab	Chemotherapy_Regimen	Anastrozole/Trastuzumab
C12028	Pentoxifylline_Vitamin-E	Chemotherapy_Regimen	Pentoxifylline/vitamin E
C12029	Cyclophosphamide_Cytarabine_Mercaptopurine_Methotrexate_Pegaspargase_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Mercaptopurine/Methotrexate/Pegaspargase/Vincristine
C12030	Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Methotrexate_Pegaspargase_Thioguanine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Methotrexate/Pegaspargase/Thioguanine/Vincristine
C12031	EGFR-Antisense-DNA_Sargramostim	Chemotherapy_Regimen	EGFR Antisense DNA/Sargramostim
C12032	EGFR-Antisense-DNA_Keyhole-Limpet-Hemocyanin	Chemotherapy_Regimen	EGFR Antisense DNA/Keyhole Limpet Hemocyanin
C12033	Calcium-Citrate_Cholecalciferol	Chemotherapy_Regimen	Calcium Citrate/Cholecalciferol
C12034	Calcium-Gluconate_Cholecalciferol	Chemotherapy_Regimen	Calcium Gluconate/Cholecalciferol
C12035	Calcium-Gluconate_Cholecalciferol_Zoledronate	Chemotherapy_Regimen	Calcium Gluconate/Cholecalciferol/Zoledronate
C12036	Calcium-Citrate_Cholecalciferol_Zoledronate	Chemotherapy_Regimen	Calcium Citrate/Cholecalciferol/Zoledronate
C12037	Calcium-Carbonate_Cholecalciferol_Zoledronate	Chemotherapy_Regimen	Calcium Carbonate/Cholecalciferol/Zoledronate
C12038	Etoposide_Ifosfamide_Imatinib-Mesylate_Methotrexate	Chemotherapy_Regimen	Etoposide/Ifosfamide/Imatinib Mesylate/Methotrexate
C12039	Cyclophosphamide_Daunorubicin_Dexamethasone_Imatinib-Mesylate_Methotrexate_Pegaspargase_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Daunorubicin/Dexamethasone/Imatinib Mesylate/Methotrexate/Pegaspargase/Vincristine
C12040	Asparaginase_Cytarabine_Imatinib-mesylate	Chemotherapy_Regimen	Asparaginase/Cytarabine/Imatinib mesylate
C12041	Cyclophosphamide_Dexamethasone_Etoposide_Imatinib-Mesylate_Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Etoposide/Imatinib Mesylate/Mercaptopurine/Methotrexate/Vincristine
C12042	Dexamethasone_Imatinib-Mesylate_Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Dexamethasone/Imatinib Mesylate/Mercaptopurine/Methotrexate/Vincristine
C12043	BMS-214662_Trastuzumab	Chemotherapy_Regimen	BMS-214662/Trastuzumab
C12044	Amifostine_Carboplatin_Fluorouracil_Paclitaxel	Chemotherapy_Regimen	Amifostine/Carboplatin/Fluorouracil/Paclitaxel
C12045	Montanide-ISA-51_Tyrosinase-related-protein-2	Chemotherapy_Regimen	Montanide ISA-51/Tyrosinase-related protein-2
C12046	Interleukin-2_Montanide-ISA-51_Tyrosinase-Related-Protein-2	Chemotherapy_Regimen	Interleukin-2/Montanide ISA-51/Tyrosinase-Related Protein-2
C12047	Carboplatin_Flavopiridol	Chemotherapy_Regimen	Carboplatin/Flavopiridol
C12048	Cyclophosphamide_Fludarabine_Oblimersen	Chemotherapy_Regimen	Cyclophosphamide/Fludarabine/Oblimersen
C12049	Triapine_Cisplatin	Chemotherapy_Regimen	Triapine/Cisplatin|3-AP/cisplatin|3AP/CDDP
C12050	Celecoxib_Cisplatin_Fluorouracil	Chemotherapy_Regimen	Celecoxib/Cisplatin/Fluorouracil
C12051	Bevacizumab_Fluorouracil_Hydroxyurea	Chemotherapy_Regimen	Bevacizumab/Fluorouracil/Hydroxyurea
C12052	Doxorubicin_PS-341	Chemotherapy_Regimen	Doxorubicin/PS-341
C12053	Probenecid_10-Propargyl-10-Deazaaminopterin	Chemotherapy_Regimen	Probenecid/10-Propargyl-10-Deazaaminopterin
C12054	Bevacizumab_Cytarabine_Idarubicin	Chemotherapy_Regimen	Bevacizumab/Cytarabine/Idarubicin
C12055	Cytarabine_Fludarabine_Isotretinoin	Chemotherapy_Regimen	Cytarabine/Fludarabine/Isotretinoin
C12056	Folic-Acid_Lometrexol_Paclitaxel	Chemotherapy_Regimen	Folic Acid/Lometrexol/Paclitaxel
C12057	Trastuzumab_ZD-1839	Chemotherapy_Regimen	Trastuzumab/ZD 1839
C12058	Doxorubicin_Strontium-Chloride-Sr-89	Chemotherapy_Regimen	Doxorubicin/Strontium Chloride Sr 89
C12059	Dacarbazine_Doxorubicin_Ifosfamide_SU5416	Chemotherapy_Regimen	Dacarbazine/Doxorubicin/Ifosfamide/SU5416
C12060	Cisplatin_Doxorubicin_Methotrexate_Trastuzumab	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Methotrexate/Trastuzumab
C12061	Cisplatin_Doxorubicin_Etoposide_Ifosfamide_Methotrexate_Trastuzumab	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Etoposide/Ifosfamide/Methotrexate/Trastuzumab
C12062	Cisplatin_Etoposide_Ifosfamide_Prednisolone	Chemotherapy_Regimen	Cisplatin/Etoposide/Ifosfamide/Prednisolone
C12063	Carboplatin_Irinotecan_Thalidomide	Chemotherapy_Regimen	Carboplatin/Irinotecan/Thalidomide
C12064	Fluorouracil_Leucovorin-Calcium_Oxaliplatin_ZD-1839	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Oxaliplatin/ZD 1839
C12065	BMS-247550_Estramustine	Chemotherapy_Regimen	BMS-247550/Estramustine
C12066	Anti-Cytotoxic-T-lymphocyte-Associated-Antigen-4-Monoclonal-Antibody_gp100-Antigen_MART-1-Antigen_Montanide-ISA-51_Tyrosinase-Peptide	Chemotherapy_Regimen	Anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody/gp100 antigen/MART-1 antigen/Montanide ISA-51/tyrosinase peptide
C12067	Docetaxel_Ifosfamide	Chemotherapy_Regimen	Docetaxel/Ifosfamide
C12068	Carboplatin_Temozolomide_Thiotepa	Chemotherapy_Regimen	Carboplatin/Temozolomide/Thiotepa
C12069	Apolizumab_Rituximab	Chemotherapy_Regimen	Apolizumab/Rituximab
C12070	Bevacizumab_Fluorouracil_Leucovorin-Calcium_Oxaliplatin	Chemotherapy_Regimen	Bevacizumab/Fluorouracil/Leucovorin Calcium/Oxaliplatin
C12071	Cyclophosphamide_Doxorubicin_Tirapazamine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Tirapazamine
C12072	BCG_Monoclonal-Antibody-105AD7-Anti-Idiotype-Vaccine	Chemotherapy_Regimen	BCG/Monoclonal Antibody 105AD7 Anti-idiotype Vaccine
C12073	Alum-Adjuvant_Monoclonal-Antibody-105AD7-Anti-Idiotype-Vaccine	Chemotherapy_Regimen	Alum Adjuvant/Monoclonal Antibody 105AD7 Anti-Idiotype Vaccine
C12074	Pentostatin_Rituximab	Chemotherapy_Regimen	Pentostatin/Rituximab
C12075	Bevacizumab_Interferon-Alfa	Chemotherapy_Regimen	Bevacizumab/Interferon Alfa
C12076	Bleomycin_Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Vinblastine_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Doxorubicin/Etoposide/Prednisone/Vinblastine/Vincristine
C12077	Oxaliplatin_ZD-1839	Chemotherapy_Regimen	Oxaliplatin/ZD 1839
C12078	Temozolomide_Vinorelbine	Chemotherapy_Regimen	Temozolomide/Vinorelbine
C12079	Erlotinib_Gemcitabine	Chemotherapy_Regimen	Erlotinib/Gemcitabine
C12080	Conjugated-Estrogens_Medroxyprogesterone	Chemotherapy_Regimen	Conjugated Estrogens/Medroxyprogesterone
C12081	Isotretinoin_Monoclonal-antibody-Ch14-18_Sargramostim	Chemotherapy_Regimen	Isotretinoin/Monoclonal antibody Ch14.18/Sargramostim
C12082	Interleukin-2_Isotretinoin_Monoclonal-Antibody-Ch14-18	Chemotherapy_Regimen	Interleukin-2/Isotretinoin/Monoclonal Antibody Ch14.18
C12083	Fluorouracil_Irinotecan_Leucovorin-Calcium_ZD-1839	Chemotherapy_Regimen	Fluorouracil/Irinotecan/Leucovorin Calcium/ZD 1839
C12084	cBR96-Doxorubicin-Immunoconjugate_Docetaxel	Chemotherapy_Regimen	cBR96-Doxorubicin Immunoconjugate/Docetaxel
C12085	Cytarabine_dexamethasone_methotrexate_pegaspargase_vincristine	Chemotherapy_Regimen	Cytarabine/dexamethasone/methotrexate/pegaspargase/vincristine
C12086	Cytarabine_Etoposide_Ifosfamide_Methotrexate_Vincristine	Chemotherapy_Regimen	Cytarabine/Etoposide/Ifosfamide/Methotrexate/Vincristine
C12087	Bevacizumab_Cisplatin_Gemcitabine	Chemotherapy_Regimen	Bevacizumab/Cisplatin/Gemcitabine
C12088	Docetaxel_Estramustine_Thalidomide	Chemotherapy_Regimen	Docetaxel/Estramustine/Thalidomide
C12089	Alemtuzumab_Fludarabine_Melphalan	Chemotherapy_Regimen	Alemtuzumab/Fludarabine/Melphalan
C12090	Autologous-Dentritic-Cells_Fowlpox-CEA-TRICOM-Vaccine	Retired_Concepts	Autologous Dendritic Cells/Fowlpox-CEA-TRICOM Vaccine
C12091	Carboplatin_Etoposide_PS-341	Chemotherapy_Regimen	Carboplatin/Etoposide/PS-341
C12092	Pegylated-Interferon-Alfa_Temozolomide	Chemotherapy_Regimen	Pegylated Interferon Alfa/Temozolomide
C12093	Bevacizumab_Docetaxel	Chemotherapy_Regimen	Bevacizumab/Docetaxel
C12094	NY-ESO-1-Peptide-Vaccine_Sargramostim	Chemotherapy_Regimen	NY-ESO-1 peptide vaccine/Sargramostim
C12095	Anti-CD3-x-Anti-HER-2-neu-BiSpecific-Monoclonal-Antibody_Autologous-Lymphocytes_Interleukin-2_Sargramostim	Chemotherapy_Regimen	Anti-CD3 x Anti-HER-2-Neu Bispecific Monoclonal Antibody/Autologous Lymphocytes/Interleukin-2/Sargramostim
C12096	Busulfan_Fludarabine	Chemotherapy_Regimen	Busulfan/Fludarabine
C12097	Temozolomide_ZD-1839	Chemotherapy_Regimen	Temozolomide/ZD 1839
C12098	Carboplatin_Cetuximab_Gemcitabine	Chemotherapy_Regimen	Carboplatin/Cetuximab/Gemcitabine
C12099	APC8015_Bevacizumab	Chemotherapy_Regimen	APC8015/Bevacizumab
C12100	ALVAC-CEA-B7-1-Vaccine_Fluorouracil_Irinotecan_Leucovorin-calcium	Chemotherapy_Regimen	ALVAC-CEA-B7.1 vaccine/Fluorouracil/Irinotecan/Leucovorin calcium
C12101	ALVAC-CEA-B7-1-Vaccine_Fluorouracil_Irinotecan_Leucovorin-calcium_Tetanus-toxoid	Chemotherapy_Regimen	ALVAC-CEA-B7.1 vaccine/Fluorouracil/Irinotecan/Leucovorin calcium/Tetanus toxoid
C12102	Anti-Thymocyte-Globulin_Cyclophosphamide_Cytarabine	Chemotherapy_Regimen	Anti-thymocyte globulin/Cyclophosphamide/Cytarabine
C12103	Carboplatin_Erlotinib_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Erlotinib/Paclitaxel
C12104	BMS-247550_Carboplatin	Chemotherapy_Regimen	BMS-247550/Carboplatin
C12105	Bevacizumab_Paclitaxel	Chemotherapy_Regimen	Bevacizumab/Paclitaxel
C12106	Interleukin-12_Paclitaxel_Trastuzumab	Chemotherapy_Regimen	Interleukin-12/Paclitaxel/Trastuzumab
C12107	Cytarabine_Imatinib-Mesylate	Chemotherapy_Regimen	Cytarabine/Imatinib Mesylate
C12108	Cyclophosphamide_Doxorubicin_Filgrastim_Prednisone_Rituximab_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Filgrastim/Prednisone/Rituximab/Vincristine
C12109	Bevacizumab_Gemcitabine	Chemotherapy_Regimen	Bevacizumab/Gemcitabine
C12110	Cytarabine_Gemtuzumab-Ozogamicin_Mitoxantrone	Chemotherapy_Regimen	Cytarabine/Gemtuzumab Ozogamicin/Mitoxantrone
C12111	Asparaginase_Cytarabine_Gemtuzumab-ozogamicin	Chemotherapy_Regimen	Asparaginase/Cytarabine/Gemtuzumab ozogamicin
C12112	Carboplatin_Epoetin-alfa_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Epoetin alfa/Paclitaxel
C12113	Carboplatin_PS-341	Chemotherapy_Regimen	Carboplatin/PS-341
C12114	Docetaxel_R101933	Chemotherapy_Regimen	Docetaxel/R101933
C12115	Paclitaxel_R101933	Chemotherapy_Regimen	Paclitaxel/R101933
C12116	Chinese-Herbs_Cyclophosphamide_Doxorubicin	Chemotherapy_Regimen	Chinese Herbs/Cyclophosphamide/Doxorubicin
C12117	Carboplatin_Paclitaxel_PS-341	Chemotherapy_Regimen	Carboplatin/Paclitaxel/PS-341
C12118	Dexamethasone_Doxorubicin	Chemotherapy_Regimen	Dexamethasone/Doxorubicin
C12119	Cyclophosphamide_Dexamethasone_Doxorubicin	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Doxorubicin
C12120	Bexarotene_Cisplatin_Vinorelbine	Chemotherapy_Regimen	Bexarotene/Cisplatin/Vinorelbine
C12121	Doxorubicin-Hcl-Liposome_Ifosfamide	Chemotherapy_Regimen	Doxorubicin Hcl Liposome/Ifosfamide
C12122	Anti-Thymocyte-Globulin_Cyclophosphamide_Fludarabine_methylprednisolone	Chemotherapy_Regimen	Anti-thymocyte globulin/Cyclophosphamide/Fludarabine/methylprednisolone
C12123	Capecitabine_Gemcitabine	Chemotherapy_Regimen	Capecitabine/Gemcitabine
C12124	Autologous-Lymphocytes_Fluorouracil_Pegylated-Interferon-Alfa_Sargramostim	Chemotherapy_Regimen	Autologous Lymphocytes/Fluorouracil/Pegylated Interferon Alfa/Sargramostim
C12125	Celecoxib_Docetaxel	Chemotherapy_Regimen	Celecoxib/Docetaxel
C12126	Isotretinoin_Monoclonal-antibody-Ch14-18	Chemotherapy_Regimen	Isotretinoin/Monoclonal antibody Ch14.18
C12127	Carboplatin_Erlotinib	Chemotherapy_Regimen	Carboplatin/Erlotinib
C12128	Cisplatin_Erlotinib	Chemotherapy_Regimen	Cisplatin/Erlotinib
C12129	Paclitaxel_PS-341	Chemotherapy_Regimen	Paclitaxel/PS-341
C12130	Montanide-ISA-51_PSA-Prostate-Cancer-Vaccine	Chemotherapy_Regimen	Montanide ISA-51/PSA prostate cancer vaccine
C12131	_506U78_Asparaginase_Daunorubicin_Methotrexate_Prednisone_Vincristine	Chemotherapy_Regimen	506U78/Asparaginase/Daunorubicin/Methotrexate/Prednisone/Vincristine
C12132	Irinotecan_UCN-01	Chemotherapy_Regimen	Irinotecan/UCN-01
C12133	Anti-Cytotoxic-T-lymphocyte-Associated-Antigen-4-Monoclonal-Antibody_gp100-Antigen_Montanide-ISA-51	Chemotherapy_Regimen	Anti-cytotoxic T-lymphocyte-associated antigen-4 monoclonal antibody/gp100 antigen/Montanide ISA-51
C12134	Alum-Adjuvant_gp100-Antigen_Interleukin-12_MART-1-Antigen_Montanide-ISA-51_Tyrosinase-Peptide	Chemotherapy_Regimen	Alum adjuvant/gp100 antigen/Interleukin-12/MART-1 antigen/Montanide ISA-51/tyrosinase peptide
C12135	gp100-Antigen_Interleukin-12_MART-1-Antigen_Montanide-ISA-51_Sargramostim_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Interleukin-12/MART-1 Antigen/Montanide ISA-51/Sargramostim/Tyrosinase Peptide
C12136	Bicalutamide_Exemestane	Chemotherapy_Regimen	Bicalutamide/Exemestane
C12137	Goserelin_Raloxifene	Chemotherapy_Regimen	Goserelin/Raloxifene
C12138	Dalteparin_Gemcitabine	Chemotherapy_Regimen	Dalteparin/Gemcitabine
C12139	Megestrol_Omega-3-Fatty-Acids	Chemotherapy_Regimen	Megestrol/Omega-3 Fatty acids
C12140	Cyclosporine_Hydroxychloroquine_Prednisone	Chemotherapy_Regimen	Cyclosporine/Hydroxychloroquine/Prednisone
C12141	Hydroxychloroquine_Prednisone_Tacrolimus	Chemotherapy_Regimen	Hydroxychloroquine/Prednisone/Tacrolimus
C12142	Bleomycin_Prednisolone_Rituximab_Vincristine	Chemotherapy_Regimen	Bleomycin/Prednisolone/Rituximab/Vincristine
C12143	Autologous-Lymphocytes_gp100-Antigen_Interleukin-2_Montanide-ISA-51	Chemotherapy_Regimen	Autologous Lymphocytes/gp100 Antigen/Interleukin-2/Montanide ISA-51
C12144	Detoxpc_Interleukin-2_RAS-Peptide-Cancer-Vaccine_Sargramostim	Chemotherapy_Regimen	Detoxpc/Interleukin-2/RAS Peptide Cancer Vaccine/Sargramostim
C12145	Asparaginase_Leucovorin-Calcium_Methotrexate	Chemotherapy_Regimen	Asparaginase/Leucovorin Calcium/Methotrexate
C12146	Cytarabine_Etoposide_Rituximab	Chemotherapy_Regimen	Cytarabine/Etoposide/Rituximab
C12147	Epoetin-Alfa_Filgrastim_Flt3-Ligand_Interleukin-3_Sargramostim	Chemotherapy_Regimen	Epoetin Alfa/Filgrastim/Flt3 Ligand/Interleukin-3/Sargramostim
C12148	Bleomycin_Cyclophosphamide_Idarubicin_Leucovorin-calcium_methotrexate_methylprednisolone_vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Idarubicin/Leucovorin calcium/methotrexate/methylprednisolone/vincristine
C12149	Allogeneic-Lymphocytes_Interleukin-2	Chemotherapy_Regimen	Allogeneic lymphocytes/Interleukin-2
C12150	Fowlpox-Virus-Vaccine_gp100-Antigen_Interleukin-2	Chemotherapy_Regimen	Fowlpox Virus Vaccine/gp100 Antigen/Interleukin-2
C12151	Alemtuzumab_Cyclophosphamide_Fludarabine	Chemotherapy_Regimen	Alemtuzumab/Cyclophosphamide/Fludarabine
C12152	Capecitabine_Carboplatin_Epirubicin	Chemotherapy_Regimen	Capecitabine/Carboplatin/Epirubicin
C12153	Gemtuzumab-Ozogamicin_Oblimersen	Chemotherapy_Regimen	Gemtuzumab Ozogamicin/Oblimersen
C12154	Dexamethasone_Oblimersen	Chemotherapy_Regimen	Dexamethasone/Oblimersen
C12155	Cisplatin_ZD-1839	Chemotherapy_Regimen	Cisplatin/ZD 1839
C12156	Aspirin_Folic-Acid	Chemotherapy_Regimen	Aspirin/Folic acid|Aspirin + Folic Acid
C12157	Erlotinib_Trastuzumab	Chemotherapy_Regimen	Erlotinib/Trastuzumab
C12158	Celecoxib_Eflornithine	Chemotherapy_Regimen	Celecoxib/Eflornithine
C12159	Dexamethasone_Thalidomide	Chemotherapy_Regimen	Dexamethasone/Thalidomide
C12160	Bupropion_Nicotine	Chemotherapy_Regimen	Bupropion/Nicotine
C12161	Etoposide_Filgrastim_Paclitaxel_Topotecan	Chemotherapy_Regimen	Etoposide/Filgrastim/Paclitaxel/Topotecan
C12162	Ethinyl-Estradiol_Norgestrel	Chemotherapy_Regimen	Ethinyl Estradiol/Norgestrel
C12163	Cytarabine_Filgrastim_Mitoxantrone	Chemotherapy_Regimen	Cytarabine/Filgrastim/Mitoxantrone
C12164	Corticotropin_Cyclophosphamide	Chemotherapy_Regimen	Corticotropin/Cyclophosphamide
C12165	Cisplatin_Dacarbazine_Doxorubicin_Mitomycin_Sargramostim	Chemotherapy_Regimen	Cisplatin/Dacarbazine/Doxorubicin/Mitomycin/Sargramostim
C12166	Interferon-Alfa_Temozolomide	Chemotherapy_Regimen	Interferon Alfa/Temozolomide
C12167	IDEC-Y2B8-Monoclonal-Antibody_Rituximab	Chemotherapy_Regimen	IDEC-Y2B8 Monoclonal Antibody/Rituximab
C12168	Aspirin_Clopidogrel-Bisulfate	Chemotherapy_Regimen	Aspirin/Clopidogrel Bisulfate
C12169	Cytarabine_Dexamethasone_Ifosfamide_Leucovorin-Calcium_Methotrexate_Teniposide_Vincristine	Chemotherapy_Regimen	Cytarabine/Dexamethasone/Ifosfamide/Leucovorin Calcium/Methotrexate/Teniposide/Vincristine
C12170	Cyclophosphamide_Dexamethasone_Doxorubicin_Leucovorin-Calcium_Methotrexate_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Doxorubicin/Leucovorin Calcium/Methotrexate/Vincristine
C12171	Bexarotene_Carboplatin_Paclitaxel	Chemotherapy_Regimen	Bexarotene/Carboplatin/Paclitaxel
C12172	Doxorubicin_Motexafin-Gadolinium	Chemotherapy_Regimen	Doxorubicin/Motexafin Gadolinium
C12173	Carboplatin_UCN-01	Chemotherapy_Regimen	Carboplatin/UCN-01
C12174	Isotretinoin_Sargramostim	Chemotherapy_Regimen	Isotretinoin/Sargramostim
C12175	Cyclophosphamide_Fluorouracil_Methotrexate_Trastuzumab	Chemotherapy_Regimen	Cyclophosphamide/Fluorouracil/Methotrexate/Trastuzumab
C12176	Cisplatin_Fluoxetine_Gemcitabine	Chemotherapy_Regimen	Cisplatin/Fluoxetine/Gemcitabine
C12177	Beta-Glucan_Monoclonal-Antibody-3F8	Chemotherapy_Regimen	Beta-Glucan/Monoclonal Antibody 3F8
C12178	MUC-2-Globo-H-KLH-Conjugate-Vaccine_QS21	Chemotherapy_Regimen	MUC-2-Globo H-KLH Conjugate Vaccine/QS21
C12179	gp100-Antigen_Melan-A_Na17-A2-Antigen_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Melan-A/Na17.A2 Antigen/Tyrosinase Peptide
C12180	MAGE-10-A2_Melan-A_NY-ESO-1-Peptide-Vaccine_Tyrosinase-Peptide	Chemotherapy_Regimen	MAGE-10.A2/Melan-A/NY-ESO-1 peptide vaccine/Tyrosinase peptide
C12181	MAGE-10-A2_Melan-A_NY-ESO-1-Peptide-Vaccine_Sargramostim_tyrosinase-Peptide	Chemotherapy_Regimen	MAGE-10.A2/Melan-A/NY-ESO-1 peptide vaccine/Sargramostim/tyrosinase peptide
C12182	Cyclophosphamide_Pentostatin_Rituximab	Chemotherapy_Regimen	Cyclophosphamide/Pentostatin/Rituximab
C12183	CpG-7909_Trastuzumab	Chemotherapy_Regimen	CpG 7909/Trastuzumab
C12184	Cytarabine_Daunorubicin_Oblimersen	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Oblimersen
C12185	BMS-275291_Zoledronate	Chemotherapy_Regimen	BMS-275291/Zoledronate
C12186	Irinotecan_Thalidomide	Chemotherapy_Regimen	Irinotecan/Thalidomide
C12187	Capecitabine_Celecoxib_ZD-1839	Chemotherapy_Regimen	Capecitabine/Celecoxib/ZD 1839
C12188	Docetaxel_Sulindac	Chemotherapy_Regimen	Docetaxel/Sulindac
C12189	Docetaxel_Ketoconazole	Chemotherapy_Regimen	Docetaxel/Ketoconazole
C12190	Cytarabine_Dexamethasone_Etoposide_Filgrastim_Ifosfamide_Leucovorin-Calcium_Methotrexate_Rituximab_Vincristine	Chemotherapy_Regimen	Cytarabine/Dexamethasone/Etoposide/Filgrastim/Ifosfamide/Leucovorin Calcium/Methotrexate/Rituximab/Vincristine
C12191	Cyclophosphamide_Cytarabine_Dexamethasone_Doxorubicin_Filgrastim_Leucovorin-Calcium_Methotrexate_Rituximab_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Dexamethasone/Doxorubicin/Filgrastim/Leucovorin Calcium/Methotrexate/Rituximab/Vincristine
C12192	Cyclophosphamide_Dexrazoxane_Doxorubicin_Oblimersen	Chemotherapy_Regimen	Cyclophosphamide/Dexrazoxane/Doxorubicin/Oblimersen
C12193	Flavopiridol_Trastuzumab	Chemotherapy_Regimen	Flavopiridol/Trastuzumab
C12194	Gemcitabine_UCN-01	Chemotherapy_Regimen	Gemcitabine/UCN-01
C12195	Cyclophosphamide_Epirubicin_Gemcitabine_Paclitaxel	Chemotherapy_Regimen	Cyclophosphamide/Epirubicin/Gemcitabine/Paclitaxel
C12196	Cyclophosphamide_Epirubicin_Paclitaxel	Chemotherapy_Regimen	Cyclophosphamide/Epirubicin/Paclitaxel
C12197	Fowlpox-CEA-TRICOM-Vaccine_Sargramostim	Chemotherapy_Regimen	Fowlpox-CEA-TRICOM Vaccine/Sargramostim
C12198	Fowlpox-CEA-TRICOM-Vaccine_Fowlpox-Sargramostim	Chemotherapy_Regimen	Fowlpox-CEA-TRICOM Vaccine/Fowlpox-Sargramostim
C12199	Ad5CMV-p53-Gene_Cisplatin_Fluorouracil	Chemotherapy_Regimen	Ad5CMV-p53 gene/Cisplatin/Fluorouracil
C12200	Ad5CMV-p53-Gene_Docetaxel	Chemotherapy_Regimen	Ad5CMV-p53 gene/Docetaxel
C12201	Fowlpox-CEA-TRICOM-Vaccine_Vaccinia-CEA-TRICOM-Vaccine	Chemotherapy_Regimen	Fowlpox-CEA-TRICOM Vaccine/Vaccinia-CEA-TRICOM Vaccine
C12202	Fowlpox-CEA-TRICOM-Vaccine_Sargramostim_Vaccinia-CEA-TRICOM-Vaccine	Chemotherapy_Regimen	Fowlpox-CEA-TRICOM Vaccine/Sargramostim/Vaccinia-CEA-TRICOM Vaccine
C12203	Cyclophosphamide_Dexamethasone_Doxorubicin_Rituximab_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dexamethasone/Doxorubicin/Rituximab/Vincristine
C12204	Cytarabine_Leucovorin-Calcium_Methotrexate_Rituximab	Chemotherapy_Regimen	Cytarabine/Leucovorin Calcium/Methotrexate/Rituximab
C12205	Carboplatin_Exisulind_Gemcitabine	Chemotherapy_Regimen	Carboplatin/Exisulind/Gemcitabine
C12206	Docetaxel_Filgrastim_Trastuzumab_Vinorelbine	Chemotherapy_Regimen	Docetaxel/Filgrastim/Trastuzumab/Vinorelbine
C12207	Carboplatin_Etoposide_Exisulind	Chemotherapy_Regimen	Carboplatin/Etoposide/Exisulind
C12208	Decitabine_FR901228	Chemotherapy_Regimen	Decitabine/FR901228
C12209	Docetaxel_Infliximab	Chemotherapy_Regimen	Docetaxel/Infliximab
C12210	Asparaginase_Cytarabine_Dexamethasone_Doxorubicin_methotrexate_thioguanine_vincristine	Chemotherapy_Regimen	Asparaginase/Cytarabine/Dexamethasone/Doxorubicin/methotrexate/thioguanine/vincristine
C12211	CpG-7909_Rituximab	Chemotherapy_Regimen	CpG 7909/Rituximab
C12212	Lycopene_MultiVitamins	Chemotherapy_Regimen	Lycopene/Multivitamins
C12213	Interferon-Alfa_Lamivudine_Zidovudine	Chemotherapy_Regimen	Interferon Alfa/Lamivudine/Zidovudine
C12214	Docetaxel_Hypericum-perforatum	Chemotherapy_Regimen	Docetaxel/Hypericum perforatum
C12215	Cisplatin_Cyclophosphamide_Doxorubicin_Teniposide	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Doxorubicin/Teniposide|AVEC|CDDP/CTX/DOX/VM-26|VACP
C12216	Fluorouracil-Uracil_Leucovorin-Calcium	Retired_Concepts	Fluorouracil-Uracil/Leucovorin Calcium
C12217	GW776_5-Fluorouracil-Combination-Tablet	Chemotherapy_Regimen	GW776/5-Fluorouracil Combination Tablet|GW776/5-FU Combination Tablet	A tablet formulation containing 5-ethynyluracil (GW776), an ethynyl derivative of uracil and the antineoplastic agent 5-Fluorouracil (5-FU) in a 10:1 ratio.  The GW776 portion of the tablet inhibits dihydropyrimidine dehydrogenase (DPD), the rate-limiting enzyme in 5-FU catabolism, thereby blocking degradation of 5-FU in the gastrointestinal tract and increasing the bioavailability of 5-FU. (NCI04)
C12218	Chemotherapy_Regimen	root_node	Chemotherapy Regimen|Chemotherapy Protocol|Combination Chemotherapy Regimen	Drug therapy using two or more drugs given together or separately for a combined effect.
C12219	Anatomic_Structure_System_or_Substance	root_node	Anatomic Structure, System, or Substance|Anatomic Structures and Systems	Naturally occurring human biological structures, fluids, and substances.  Includes embryological, gross and micro anatomic structures.  Excludes proteins and protein complexes smaller than that that can be visualized by light microscopy.
C12220	Lip	Head_and_Neck_Part	Lip	Either of the two fleshy, full-blooded margins of the mouth. (MeSH)
C12221	External_Upper_Lip	External_Lip	External Upper Lip
C12222	External_Lower_Lip	External_Lip	External Lower Lip
C12223	External_Lip	Head_and_Neck_Part	External Lip|External Lip, NOS
C12224	Mucosa_of_the_Upper_Lip	Mucosa_of_the_Lip	Mucosa of the Upper Lip|Mucosa of Upper Lip	The lining of the superior fleshy fold bordering the mouth. It is comprised of the epithelium, basement membrane, lamina propria mucosae, and lamina muscularis mucosae.
C12225	Mucosa_of_the_Lower_Lip	Mucosa_of_the_Lip	Mucosa of the Lower Lip|Mucosa of Lower Lip	The lining of the inferior fleshy fold bordering the mouth. It is comprised of the epithelium, basement membrane, lamina propria mucosae, and lamina muscularis mucosae.
C12226	Mucosa_of_the_Lip	Mucosa	Mucosa of the Lip|Mucosa of Lip|Mucosa of Lip, NOS	The lining of the fleshy folds surrounding the mouth. It is comprised of the epithelium, basement membrane, lamina propria mucosae, and lamina muscularis mucosae.
C12227	Commissure_of_the_Lip	Head_and_Neck_Part	Commissure of the Lip|Commissure of Lip
C12228	Base_of_the_Tongue	Organ_of_Special_Sense_Part	Base of the Tongue|Base of Tongue
C12229	Palate	Head_and_Neck_Part	Palate|palate	(PAL-et) The roof of the mouth. The front portion is bony (hard palate), and the back portion is muscular (soft palate).
C12230	Hard_Palate	Head_and_Neck_Part	Hard Palate	The anteriorly located rigid section of the palate. (MeSH)
C12231	Soft_Palate	Head_and_Neck_Part	Soft Palate	A movable fold suspended from the posterior border of the hard palate. (MeSH)
C12232	Uvula	Head_and_Neck_Part	Uvula
C12233	Submandibular_Gland	Major_Salivary_Gland	Submandibular Gland|Submaxillary Gland	One of two salivary glands in the neck, located in the space bound by the two bellies of the digastric muscle and the angle of the mandible. It discharges through the submandibular duct. (MeSH)
C12234	Sublingual_Salivary_Gland	Major_Salivary_Gland	Sublingual Salivary Gland|Sublingual Gland
C12235	Tonsillar_Fossa	Fossa|Tonsil_Part	Tonsillar Fossa
C12236	Tonsillar_Pillar	Tonsil_Part	Tonsillar Pillar
C12237	Vallecula	Brain_Part	Vallecula
C12238	Anterior_Surface_of_the_Epiglottis	Anatomic_Surface	Anterior Surface of the Epiglottis|Anterior Surface of Epiglottis
C12239	Lateral_Wall_of_the_Oropharynx	Head_and_Neck_Part	Lateral Wall of the Oropharynx|Lateral Wall of Oropharynx
C12240	Posterior_Wall_of_the_Oropharynx	Head_and_Neck_Part	Posterior Wall of the Oropharynx|Posterior Wall of Oropharynx
C12241	Branchial_Cleft	Retired_Concepts	Branchial Cleft
C12242	Superior_Wall_of_the_Nasopharynx	Head_and_Neck_Part	Superior Wall of the Nasopharynx|Superior Wall of Nasopharynx
C12243	Posterior_Wall_of_the_Nasopharynx	Head_and_Neck_Part	Posterior Wall of the Nasopharynx|Posterior Wall of Nasopharynx
C12244	Lateral_Wall_of_the_Nasopharynx	Head_and_Neck_Part	Lateral Wall of the Nasopharynx|Lateral Wall of Nasopharynx
C12245	Anterior_Wall_of_the_Nasopharynx	Head_and_Neck_Part	Anterior Wall of the Nasopharynx|Anterior Wall of Nasopharynx
C12246	Hypopharynx	Head_and_Neck_Part	Hypopharynx|hypopharynx	The bottom part of the throat. Cancer of the hypopharynx is also called hypopharyngeal cancer.
C12247	Postcricoid_Region	Retired_Concepts	Postcricoid Region
C12248	Hypopharyngeal_Aspect_of_Aryepiglottic_Fold	Retired_Concepts	Hypopharyngeal Aspect of the Aryepiglottic Fold|Hypopharyngeal Aspect of Aryepiglottic Fold
C12249	Posterior_Wall_of_the_Hypopharynx	Head_and_Neck_Part	Posterior Wall of the Hypopharynx|Posterior Wall of Hypopharynx
C12250	Cervical_Esophagus	Body_Region	Cervical Esophagus
C12251	Thoracic_Esophagus	Body_Region	Thoracic Esophagus
C12252	Abdominal_Esophagus	Body_Region	Abdominal Esophagus
C12253	Upper_Third_of_the_Esophagus	Body_Region	Upper Third of the Esophagus|Upper Third of Esophagus
C12254	Middle_Third_of_the_Esophagus	Body_Region	Middle Third of the Esophagus|Middle Third of Esophagus
C12255	Lower_Third_of_the_Esophagus	Body_Region	Lower Third of the Esophagus|Lower Third of Esophagus
C12256	Cardia	Gastrointestinal_System_Part	Gastric Cardia|Cardia|Cardia, NOS Gastric Cardia
C12257	Fundus_of_the_Stomach	Gastrointestinal_System_Part	Fundus of the Stomach|Fundus of Stomach	The superior portion of the body of the stomach above the level of the cardiac notch. (MeSH)
C12258	Body_of_Stomach	Gastrointestinal_System_Part	Body of Stomach
C12259	Antrum_Pylori	Gastrointestinal_System_Part	Antrum Pylori|Gastric Antrum
C12260	Pylorus	Gastrointestinal_System_Part	Pylorus
C12261	Lesser_Curvature	Gastrointestinal_System_Part	Lesser Curvature of the Stomach|Lesser Curvature of Stomach, NOS	not classifiable to C16.1 to C16.4
C12262	Greater_Curvature	Gastrointestinal_System_Part	Greater Curvature of the Stomach|Greater Curvature|Greater Curvature of Stomach, NOS	not classifiable to C16.0 to C16.4
C12263	Duodenum	Gastrointestinal_System_Part	Duodenum|duodenum	(doo-ah-DEE-num) The first part of the small intestine.
C12264	Meckel_Diverticulum	Diverticulum	Meckel Diverticulum|Meckel's Diverticulum
C12265	Ascending_Colon	Gastrointestinal_System_Part	Ascending Colon|Ascending colon
C12266	Hepatic_Flexure	Gastrointestinal_System_Part	Hepatic Flexure|Hepatic Flexure of Colon|Hepatic Flexure of the Colon
C12267	Splenic_Flexure	Gastrointestinal_System_Part	Splenic Flexure|Splenic Flexure of Colon
C12268	Descending_Colon	Gastrointestinal_System_Part	Descending Colon|Descending colon
C12269	Head_of_the_Pancreas	Gastrointestinal_System_Part	Head of the Pancreas|Head of Pancreas
C12270	Body_of_the_Pancreas	Gastrointestinal_System_Part	Body of the Pancreas|Body of Pancreas
C12271	Tail_of_the_Pancreas	Gastrointestinal_System_Part	Tail of the Pancreas|Tail of Pancreas
C12272	Pancreatic_Duct	Duct	Pancreatic Duct|Canal of Wirsung|pancreatic ducts	A system of ducts in the pancreas. Pancreatic juices containing enzymes are released into these ducts and flow into the small intestine.
C12273	Other_Specified_Parts_of_Pancreas	Other_Anatomic_Concept	Other Specified Parts of Pancreas
C12274	Middle_Ear	Ear_Part	Middle Ear
C12275	Maxillary_Sinus	Paranasal_Sinus	Maxillary Sinus|Antrum Highmori|Antrum of Highmore|Antrum of Highmori|Antrum, Maxillary|Apertura Sinus Maxillaris|Sinus, Maxillary
C12276	Ethmoid_Sinus	Paranasal_Sinus	Ethmoid Sinus|Sinus, Ethmoid
C12277	Frontal_Sinus	Paranasal_Sinus	Frontal Sinus|Sinus, Frontal	The paired, mucosal lined air spaces located above the orbit and communicating with the nasal passages.
C12278	Sphenoid_Sinus	Paranasal_Sinus	Sphenoid Sinus|Sinus, Sphenoid
C12279	Supraglottis	Head_and_Neck_Part	Supraglottis|supraglottis	(SOO-pra-GLOT-is) The upper part of the larynx (voice box), including the epiglottis; the area above the vocal cords.
C12280	Subglottis	Head_and_Neck_Part	Subglottis|subglottis	(SUB-glot-is) The lowest part of the larynx; the area from just below the vocal cords down to the top of the trachea.
C12281	Laryngeal_Cartilage	Cartilage	Laryngeal Cartilage	The nine cartilages of the larynx, including the cricoid, thyroid and epiglottic, and two each of arytenoid, corniculate and cuneiform. (MeSH)
C12283	Lung_and_Bronchus	Retired_Concepts	Lung and Bronchus
C12284	Main_Bronchus	Bronchus	Main Bronchus
C12285	Lung_Upper_Lobe	Lung_Lobe	Upper Lobe of the Lung|Lung Upper Lobe|Upper Lobe, Lung
C12286	Middle_Lobe_of_the_Right_Lung	Lung_Lobe	Middle Lobe of the Right Lung|RML|Right Middle Lobe, Lung
C12287	Lung_Lower_Lobe	Lung_Lobe	Lower Lobe of the Lung|Lower Lobe, Lung|Lung Lower Lobe
C12289	Bone_of_Skull_and_Face_and_Associated_Joints	Retired_Concepts	Bone of Skull and Face and Associated Joints|Bones of Skull and Face and Associated Joints	excludes mandible C41.1
C12290	Mandible	Irregular_Bone	Mandible|Inferior Maxillary Bone
C12291	Skin_of_the_Lip	Skin	Skin of the Lip|Skin of Lip|Skin of Lip, NOS
C12292	External_Ear	Ear_Part	External Ear|Auricle|Ear, External|Pinna
C12293	Skin_of_Other_and_Unspecified_Parts_of_Face	Other_Anatomic_Concept	Skin of Other and Unspecified Parts of Face
C12294	Skin_of_the_Scalp_and_Neck	Skin	Skin of the Scalp and Neck|Skin of Scalp and Neck
C12295	Skin_of_the_Trunk	Skin	Skin of the Trunk|Skin of Trunk
C12296	Skin_of_the_Upper_Limb_and_Shoulder	Skin	Skin of the Upper Limb and Shoulder|Skin of Upper Limb and Shoulder
C12297	Skin_of_the_Lower_Limb_and_Hip	Skin	Skin of the Lower Limb and Hip|Skin of Lower Limb and Hip
C12298	Retroperitoneum	Body_Region	Retroperitoneum|Retroperitoneal Cavity|Retroperitoneal Space	The back of the abdomen where the kidneys lie and the great blood vessels run.
C12299	Nipple	Breast-Related_Entity	Nipple	The pigmented projection on the surface of the breast. Ducts that conduct milk from the mammary glands to the surface of the breast exit through the nipple. (from MedTerms Medical Dictionary; medterms.com)
C12300	Central_Portion_of_the_Breast	Breast-Related_Entity	Central Portion of the Breast|Central Portion of Breast
C12301	Upper-inner_Quadrant_of_the_Breast	Breast-Related_Entity	Upper-Inner Quadrant of the Breast|Upper-inner Quadrant of Breast
C12302	Lower-inner_Quadrant_of_the_Breast	Breast-Related_Entity	Lower-Inner Quadrant of the Breast|Lower-inner Quadrant of Breast
C12303	Upper-outer_Quadrant_of_the_Breast	Breast-Related_Entity	Upper-Outer Quadrant of the Breast|Upper-outer Quadrant of Breast
C12304	Lower-outer_Quadrant_of_the_Breast	Breast-Related_Entity	Lower-Outer Quadrant of the Breast|Lower-outer Quadrant of Breast
C12305	Axillary_Tail_of_the_Breast	Breast-Related_Entity	Axillary Tail of the Breast|Axillary Tail of Breast
C12306	Labium_Majus	Female_Reproductive_System_Part	Labium Majus
C12307	Labium_Minus	Female_Reproductive_System_Part	Labium Minus
C12308	Clitoris	Female_Reproductive_System_Part	Clitoris
C12309	Endocervix	Female_Reproductive_System_Part	Endocervix
C12310	Ectocervix	Female_Reproductive_System_Part	Ectocervix|Exocervix
C12311	Cervix	Female_Reproductive_System_Part	Cervix Uteri|Cervix|Genital System, Female, Cervix|Uterine Cervix|Uterus, cervix|cervix	(SER-viks) The lower, narrow end of the uterus that forms a canal between the uterus and vagina.
C12312	Isthmus_Uteri	Female_Reproductive_System_Part	Isthmus Uteri
C12313	Endometrium	Mucosa	Endometrium|endometrium	(en-do-MEE-tree-um) The layer of tissue that lines the uterus.
C12314	Myometrium	Smooth_Muscle_Tissue	Myometrium|myometrium	(mye-o-MEE-tree-um) The muscular outer layer of the uterus.
C12315	Fundus_Uteri	Female_Reproductive_System_Part	Fundus Uteri
C12316	Corpus_Uteri	Female_Reproductive_System_Part	Corpus Uteri|Corpus|Uterine Body|Uterus, corpus|corpus	The Corpus uteri, or body of uterus, is the part of the uterus above the isthmus, comprising about two thirds of the non-pregnant organ.
C12317	Other_and_Unspecified_Female_Genital_Organ	Retired_Concepts	Other and Unspecified Female Genital Organ|Other and Unspecified Female Genital Organs
C12318	Broad_Ligament	Ligament	Broad Ligament|Lateral Ligament	A broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis. (MeSH)
C12319	Round_Ligament	Ligament	Round Ligament	A fibromuscular band that attaches to the uterus and then passes along the broad ligament, out through the inguinal ring, and into the labium majus. (MeSH)
C12320	Parametrium	Tissue	Parametrium	The connective tissue of the pelvic floor extending from the fibrous subserous coat of the supracervical portion of the uterus laterally between the layers of the broad ligament. (On-line Medical Dictionary)
C12321	Appendage_of_the_Uterus	Female_Reproductive_System_Part	Appendage of the Uterus|Uterine Adnexa	The fallopian tubes, ovaries, and supporting ligaments of the uterus. (MeSH)
C12322	Other_Specified_Parts_of_Female_Genital_Organ	Retired_Concepts	Other Specified Parts of Female Genital Organ|Other Specified Parts of Female Genital Organs
C12323	Prepuce	Reproductive_System_Part	Prepuce|Preputium Penis	A covering fold of skin, often used alone to designate the preputium penis. (On-line Medical Dictionary)
C12324	Glans_Penis	Male_Reproductive_System_Part	Glans Penis
C12325	Body_of_the_Penis	Male_Reproductive_System_Part	Body of the Penis|Body of Penis
C12326	Undescended_Testis	Testicular_Non-Neoplastic_Disorder	Undescended Testis|Cryptorchidism|cryptorchidism|undescended testicles	A condition in which one or both testicles fail to move from the abdomen, where they develop before birth, into the scrotum. Undescended testicles may increase the risk for development of testicular cancer.
C12327	Descended_Testis	Retired_Concepts	Descended Testis
C12328	Epididymis	Organ	Epididymis
C12329	Spermatic_Cord	Organ	Spermatic Cord
C12330	Other_Specified_Parts_of_Male_Genital_Organs	Retired_Concepts	Other Specified Parts of Male Genital Organs
C12331	Bladder_Trigone	Urinary_System_Part	Bladder Trigone|Trigone of Bladder|Urinary Bladder Trigone
C12332	Dome_of_the_Bladder	Urinary_System_Part	Dome of the Bladder|Dome of Bladder|Superior Surface of Bladder|Superior Surface of the Bladder
C12333	Lateral_Wall_of_the_Bladder	Urinary_System_Part	Lateral Wall of the Bladder|Lateral Wall of Bladder
C12334	Anterior_Wall_of_the_Bladder	Urinary_System_Part	Anterior Wall of the Bladder|Anterior Wall of Bladder
C12335	Posterior_Wall_of_the_Bladder	Urinary_System_Part	Posterior Wall of the Bladder|Posterior Wall of Bladder
C12336	Bladder_Neck	Urinary_System_Part	Bladder Neck|Neck of Bladder
C12337	Ureteric_Orifice	Urinary_System_Part	Ureteric Orifice|Orifice of the Ureter
C12338	Urachus	Other_Embryologic_Structure	Urachus|urachus	(YOU-rah-kus) A fibrous cord that connects the urinary bladder to the umbilicus (navel).  The urachus is formed as the allantoic stalk during fetal development and lasts through life.  Also called the median umbilical ligament.
C12339	Paraurethral_Gland	Exocrine_Gland	Paraurethral Gland
C12340	Eye_and_Adnexa	Retired_Concepts	Eye and Adnexa
C12341	Conjunctiva	Eye_Appendage|Mucosa	Conjunctiva|conjunctiva	A membrane that lines the inner surface of the eyelid and also covers the front part of the eye.  Conjunctivitis is inflammation of the conjunctiva.
C12342	Cornea	Eye_Part	Cornea|cornea	The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous epithelium, Bowman's membrane, stroma, Descemet's membrane, and mesenchymal endothelium. It serves as the first refracting medium of the eye. It is structurally continuous with the sclera, is avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the trigeminal nerve via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses.
C12343	Retina	Eye_Part|Tissue	Retina	The light-sensitive membrane covering the back wall of the eyeball; it is continuous with the optic nerve.
C12344	Choroid	Membrane	Choroid
C12345	Ciliary_Body	Eye_Part	Ciliary Body
C12346	Lacrimal_Gland	Exocrine_Gland	Lacrimal Gland
C12347	Orbit	Cavity|Musculoskeletal_System_Part	Orbit|Eye Socket|Ocular Orbit|Orbital Cavity	The bony cavity of the skull which contains the eye, anterior portion of the optic nerve, ocular muscles and ocular adnexa.  Seven bones contribute to the structure of the orbit: the frontal, maxillary, zygomatic, sphenoid, lacrimal, ethmoid, and palatine bones.
C12348	Meninges	Membrane_of_the_Brain_or_Spinal_Cord	Meninges|meninges	(meh-NIN-jeez) The three membranes that cover and protect the brain and spinal cord.
C12349	Cerebral_Meninges	Meninges	Cerebral Meninges	The membranes that envelop and protect the brain.
C12350	Spinal_Meninges	Meninges	Spinal Meninges	Connective tissue membranes that surround and support the spinal cord and cauda equina. They are continuous with cranial meninges, which surround and support the brain.
C12351	Cerebral_Hemisphere	Brain_Part	Cerebral Hemisphere|Brain Hemisphere|Cerebral Hemispheres|cerebral hemisphere|cerebrum	(seh-REE-bral HEM-iss-feer) One half of the cerebrum, the part of the brain that controls muscle functions and also controls speech, thought, emotions, reading, writing, and learning. The right hemisphere controls the muscles on the left side of the body, and the left hemisphere controls the muscles on the right side of the body.
C12352	Frontal_Lobe	Brain_Part	Frontal Lobe|Frontal Cortex
C12353	Temporal_Lobe	Brain_Part	Temporal Lobe|Temporal Cortex
C12354	Parietal_Lobe_of_the_Brain	Brain_Part	Parietal Lobe|Parietal Lobe of the Brain
C12355	Occipital_Lobe	Brain_Part	Occipital Lobe|Occipital Cortex	The posterior part of the cerebral hemisphere. (MeSH)
C12356	Ventricle_Brain	Brain_Part	Brain Ventricle|Ventricle|Ventricle of Brain|Ventricle, Brain|Ventricles|Ventricles, Brain	The ventricles of the brain are four connected cavities (hollow spaces) centrally located within the brain that connect posteriorly with the central canal of the spinal cord.  All of these spaces are developmentally derived from the central canal of the embryonic neural tube.
C12357	Craniopharyngeal_Duct	Other_Anatomic_Concept	Craniopharyngeal Duct
C12358	Head_and_Neck_Lymph_Node	Lymph_Node_by_Anatomic_Site	Head and Neck Lymph Node|Lymph Node of Head, Face and Neck|Lymph Nodes of Head, Face and Neck
C12359	Intrathoracic_Lymph_Node	Lymph_Node_by_Anatomic_Site	Intrathoracic Lymph Node|Intrathoracic Lymph Nodes	Any lymph node within the thoracic cavity.
C12360	Intra-abdominal_Lymph_Node	Lymph_Node_by_Anatomic_Site	Intra-Abdominal Lymph Node|Intra-abdominal Lymph Node|Intra-abdominal Lymph Nodes	Any lymph node within the abdomen.
C12361	Lymph_Node_of_Axilla_or_Arm	Retired_Concepts	Lymph Node of Axilla or Arm|Lymph Nodes of Axilla or Arm
C12362	Lymph_Node_of_Inguinal_Region_or_Leg	Lymph_Node_by_Anatomic_Site	Lymph Node of Inguinal Region or Leg|Lymph Nodes of Inguinal Region or Leg
C12363	Pelvic_Lymph_Node	Lymph_Node_by_Anatomic_Site	Pelvic Lymph Node|Pelvic Lymph Nodes	Any lymph node within the pelvic region.
C12365	Amnion	Extraembryonic_Structure	Amnion	The extraembryonic membrane which contains the embryo and amniotic fluid. (MeSH)
C12366	Bone	Musculoskeletal_System_Part	Bone|Bones	A rigid connective tissue that makes up the skeleton of vertebrates.
C12367	Mammary_Gland	Breast-Related_Entity|Exocrine_Gland	Mammary Gland	In humans, the glands of the breast, consisting of fibrous tissue connecting the lobes and fatty tissue in between the lobes.
C12368	Areola	Breast-Related_Entity	Areola|areola	(a-REE-o-la) The area of dark-colored skin on the breast that surrounds the nipple.
C12369	Breast_Fat_Pad	Breast-Related_Entity	Breast Fat Pad|Mammary Gland Fat Pad|Mammary Gland Fat-pad
C12370	Mammary_Gland_Tissue	Tissue	Mammary Gland Tissue|Breast Tissue|Mammary Gland Parenchyma	Tissue of the gland of the skin of female mammals that secretes milk. In the human female, it is composed of numerous lobules having alveolar ducts and alveoli, which are the secretory portion of the gland.
C12371	Myocardium	Striated_Muscle_Tissue	Myocardium|Cardiac Muscle|Heart Muscle|Myocardial Tissue	The main substance of the muscular wall of the heart enclosed between the epicardium and endocardium and composed of striated, involuntary cardiac muscle. (MeSH)
C12372	Artery	Blood_Vessel	Artery	is a blood vessel of macroscopic dimensions, the lumen of which is continuous with the ventricles of the heart, directly or indirectly through branches of the aorta and pulmonary trunk. Example(s): bronchial artery, renal artery, anterior interventricular branch of left coronary artery, truncus anterior of right pulmonary artery.
C12373	Cartilage	Musculoskeletal_System_Part	Cartilage|cartilage	(KAR-tih-lij) A tough, flexible tissue that lines joints and gives structure to the nose, ears, larynx, and other parts of the body.
C12374	Connective_Tissue	Connective_and_Soft_Tissue	Connective Tissue|connective tissue	Supporting tissue that surrounds other tissues and organs. Specialized connective tissue includes bone, cartilage, blood, and fat.
C12375	Anal_Canal	Gastrointestinal_System_Part	Anal Canal	excludes skin of anus and perianal skin C44.5
C12376	Bile_Duct	Duct	Bile Duct|bile duct	A tube through which bile passes in and out of the liver.
C12377	Gallbladder	Organ	Gallbladder|Gall Bladder|Gallbladder / Biliar|Gallbladder/Biliary system|Gastrointestinal Tract, Gall Bladder|gallbladder	(GAWL-blad-er) The pear-shaped organ found below the liver. Bile is concentrated and stored in the gallbladder.
C12378	Gastrointestinal_System	Organ_System	Gastrointestinal System|Body System, Gastrointestinal|Digestive System|Digestive System (All Sites)|Gastrointestinal Body System|Gastrointestinal Organ System|Organ System, Gastrointestinal	The system that includes the esophagus, stomach, small and large intestine, anus, liver, biliary tract, and pancreas.
C12379	Large_Intestine	Gastrointestinal_System_Part	Large Intestine|Large Bowel|large intestine	The long, tube-like organ that is connected to the small intestine and rectum. The large intestine removes water and some nutrients and electrolytes from digested food. The remaining material, solid waste called stool, moves through the large intestine to the rectum and leaves the body through the anus. Also called the colon.
C12380	Vermiform_Appendix	Gastrointestinal_System_Part	Appendix|Vermiform Appendix|appendix	A small, fingerlike pouch that sticks out from the cecum (the first part of the large intestine near the end of the small intestine).
C12381	Cecum	Gastrointestinal_System_Part	Cecum
C12382	Colon	Gastrointestinal_System_Part	Colon|Large Intestine|colon	(KO-lun) The long, tube-like organ that is connected to the small intestine and rectum. The colon removes water and some nutrients and electrolytes from digested food. The remaining material, solid waste called stool, moves through the colon to the rectum and leaves the body through the anus. Also called the large intestine.
C12383	Right_Colon	Gastrointestinal_System_Part	Right Colon
C12384	Sigmoid_Colon	Gastrointestinal_System_Part	Sigmoid Colon
C12385	Transverse_Colon	Gastrointestinal_System_Part	Transverse Colon
C12386	Small_Intestine	Gastrointestinal_System_Part	Small Intestine|Gastrointestinal Tract, Small Intestine|SB|Small Bowel|small intestine	The part of the digestive tract that is located between the stomach and the large intestine.
C12387	Ileum	Gastrointestinal_System_Part	Ileum|ileum	excludes ileocecal valve C18.0
C12388	Jejunum	Gastrointestinal_System_Part	Jejunum
C12389	Esophagus	Organ	Esophagus|ESOPH|Gastrointestinal Tract, Esophagus|esophagus	(eh-SOF-a-gus) The muscular tube through which food passes from the throat to the stomach.
C12390	Rectum	Gastrointestinal_System_Part	Rectum|RCTM|rectum	The last 6 inches of the large intestine.
C12391	Stomach	Organ	Stomach|Gastrointestinal Tract, Stomach|stomach	An organ that is part of the digestive system. It helps in the digestion of food by mixing it with digestive juices and churning it into a thin liquid.
C12392	Liver	Organ	Liver|Body System, Hepatic|Gastrointestinal Tract, Liver|Hepatic Body System|Hepatic Organ System|L|Organ System, Hepatic|liver	A large organ located in the upper abdomen. The liver cleanses the blood and aids in digestion by secreting bile.
C12393	Pancreas	Organ	Pancreas|Gastrointestinal Tract, Pancreas|pancreas	A glandular organ located in the abdomen. It makes pancreatic juices, which contain enzymes that aid in digestion, and it produces several hormones, including insulin. The pancreas is surrounded by the stomach, intestines, and other organs.
C12394	Ear	Organ_of_the_Special_Sense	Ear	The organ of hearing: composed of the external ear, which includes the auricle and the external acoustic, or auditory, meatus; the middle ear, or the tympanic cavity with its ossicles; and the internal ear or inner ear, or labyrinth, which includes the semicircular canals, vestibule, and cochlea. (from MSH98)
C12395	Cochlea	Ear_Part	Cochlea|Cochlear Organ	The part of the internal ear that is concerned with hearing. It forms the anterior part of the labyrinth, is conical, and is placed almost horizontally anterior to the vestibule.
C12396	Adrenal_Cortex	Adrenal_Gland_Tissue|Glandular_Epithelial_Tissue	Adrenal Cortex|Cortex of adrenal gland	The outer layer of the adrenal gland. It secretes mineralocorticoids, androgens, and glucocorticoids. (MeSH)
C12397	Adrenal_Medulla	Adrenal_Gland_Tissue|Neuroendocrine_Tissue	Adrenal Medulla|Medulla of adrenal gland	The inner part of the adrenal gland; it synthesizes, stores and releases catecholamines. (MeSH)
C12398	Pineal_Gland	Endocrine_Gland	Pineal Gland|Pineal Body|pineal body|pineal gland|pineal organ	(PIN-ee-al) A tiny organ in the cerebrum that produces melatonin.
C12399	Pituitary_Gland	Endocrine_Gland	Pituitary Gland|Hypophysis|Hypophysis Cerebri|Nervous System, Pituitary|Pituitary|pituitary gland	(pih-TOO-ih-tair-ee) The main endocrine gland. It produces hormones that control other glands and many body functions, especially growth.
C12400	Thyroid_Gland	Endocrine_Gland	Thyroid Gland|Head and Neck, Thyroid|Thyroid|Thyroid gland|thyroid|thyroid gland	(THIGH-royd) A gland located beneath the voice box (larynx) that produces thyroid hormone. The thyroid helps regulate growth and metabolism.
C12401	Eye	Organ_of_the_Special_Sense	Eye|Eyeball|Eyes	The organ of sight or vision. (On-line Medical Dictionary)
C12402	Female_Reproductive_System	Reproductive_System	Female Reproductive System|Body System, Gynecologic|Body System, Reproductive, Female|Female Reproductive Body System|Female Reproductive Organ System|Genital System, Female|Gynecologic Body System|Gynecologic Organ System|Organ System, Female Reproductive|Organ System, Gynecologic|Reproductive System, Female
C12403	Fallopian_Tube	Appendage_of_the_Uterus|Organ	Fallopian Tube|Fallopian Tubes|fallopian tubes	(fa-LO-pee-in) Part of the female reproductive tract. The long slender tubes through which eggs pass from the ovaries to the uterus.
C12404	Ovary	Appendage_of_the_Uterus|Organ	Ovary|Genital System, Female, Ovary|Ovaries|ovaries	(O-va-reez) The pair of female reproductive glands in which the ova, or eggs, are formed. The ovaries are located in the pelvis, one on each side of the uterus.
C12405	Uterus	Organ	Uterus|Genital System, Female, Uterus|uterus|womb	(YOO-ter-us) The small, hollow, pear-shaped organ in a woman's pelvis. This is the organ in which a fetus develops.
C12406	Pregnant_Uterus	Uterus	Pregnant Uterus
C12407	Vagina	Organ	Vagina|Genital System, Female, Vagina|VAG|vagina	(vah-JYE-na) The muscular canal extending from the uterus to the exterior of the body. Also called the birth canal.
C12408	Vulva	Organ	Vulva|External Genitalia|vulva	The external female genital organs, including the clitoris, vaginal lips, and the opening to the vagina.
C12409	Penis	Organ	Penis|Genital System, Male, Penis|penis	An external male reproductive organ. It contains a tube called the urethra, which carries semen and urine to the outside of the body.
C12410	Prostate_Gland	Exocrine_Gland	Prostate Gland|Genital System, Male, Prostate|Human Prostate|Human Prostate Gland|PRS|Prostate|Prostatic Gland|prostate	(PROS-tate) A gland in the male reproductive system just below the bladder.  The prostate surrounds part of the urethra, the canal that empties the bladder, and produces a fluid that forms part of semen.
C12411	Prostate_MF	Other_Anatomic_Concept	Prostate MF
C12412	Testis	Organ	Testis|Genital System, Male, Testis|Testes|Testicle|Testicles|testicles	(TES-tih-kuls) The two egg-shaped glands found inside the scrotum. They produce sperm and male hormones.  Also called testes.
C12413	Urinary_System	Organ_System	Urinary System|Body System, Renal/Urologic|Organ System, Renal/Urologic|Renal/Urologic Body System|Renal/Urologic Organ System|Urinary Tract|Urinary tract|Urinary tract (all sites)|Urologic/Renal Body System|urinary|urinary tract	(YOO-rin-air-ee) The organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra.
C12414	Bladder	Organ	Bladder|BLAD|Urinary Bladder|Urinary System, Bladder|bladder	A distensible musculomembranous organ serving as a receptacle for fluid, as the gallbladder.
C12415	Kidney	Organ	Kidney|Kidneys|Urinary System, Kidney|kidneys	(KID-neez) A pair of organs in the abdomen that remove waste from the blood (as urine), produce erythropoietin (a substance that stimulates red blood cell production), and play a role in blood pressure regulation.
C12416	Ureter	Organ	Ureter|ureter	(yoo-REE-ter) The tube that carries urine from the kidney to the bladder.
C12417	Urethra	Organ	Urethra|urethra	(yoo-REE-thra) The tube through which urine leaves the body. It empties urine from the bladder.
C12418	Head_and_Neck	Body_Region	Head and Neck|H and N|H and N - Head And Neck	For oncology, area of the body generally construed to comprise base of skull and facial bones, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature and lymph nodes draining these areas.
C12419	Head	Body_Region	Head	The anterior or superior part of an animal, containing the brain, or chief ganglia of the nervous system, the mouth, and in the higher animals, the chief sensory organs. (On-line Medical Dictionary)
C12420	Larynx	Head_and_Neck_Part	Larynx|Head and Neck, Larynx|LNX|larynx	(LAIR-inks) The area of the throat containing the vocal cords and used for breathing, swallowing, and talking. Also called the voice box.
C12421	Oral_Cavity	Cavity	Oral Cavity|Buccal Cavity|Head and Neck, Buccal Cavity|Mouth	The cavity lying at the upper end of the alimentary canal, bounded on the outside by the lips and inside by the oropharynx and containing in humans the tongue, gums, and teeth.
C12422	Tongue	Organ_of_the_Special_Sense	Tongue
C12423	Nasopharynx	Head_and_Neck_Part	Nasopharynx|nasopharynx	(NAY-zo-fair-inks) The upper part of the throat behind the nose. An opening on each side of the nasopharynx leads into the ear.
C12424	Nasal_Cavity	Cavity	Nasal Cavity|nasal cavity	The proximal portion of the respiratory passages on either side of the nasal septum, lined with ciliated mucosa, extending from the nares to the pharynx. (MeSH)
C12425	Pharynx	Head_and_Neck_Part	Pharynx|Head and Neck, Pharynx|pharynx	(FAIR-inks) The hollow tube about 5 inches long that starts behind the nose and ends at the top of the trachea (windpipe) and esophagus (the tube that goes to the stomach).
C12426	Salivary_Gland	Exocrine_Gland	Salivary Gland|Head and Neck, Salivary Glands|OTHER AND UNSPECIFIED MAJOR SALIVARY GLANDS|Salivary Glands|salivary glands	(SAL-ih-vair-ee) Glands in the mouth that produce saliva.
C12427	Parotid_Gland	Major_Salivary_Gland|Serous_Salivary_Gland	Parotid Gland|Parotid
C12428	Trachea	Organ	Trachea|Trachea Proper|trachea|windpipe	(TRAY-kee-uh) The airway that leads from the larynx to the lungs.
C12429	Limb	Body_Region	Limb|Extremities|Extremity	A body region referring to an upper or lower extremity.
C12430	Lymphoreticular_Tissue	Retired_Concepts	Lymphoreticular Tissue|lymphoreticular
C12431	Bone_Marrow	Organ	Bone Marrow|BM|Reticuloendothelial System, Bone Marrow|bone marrow	The soft, sponge-like tissue in the center of bones that produces white blood cells, red blood cells, and platelets.
C12432	Spleen	Organ	Spleen|Reticuloendothelial System, Spleen|spleen	An organ that is part of the hematopoietic and immune systems.  It is composed of the white pulp and the red pulp and is surrounded by a capsule.  It is located in the left hypochondriac region.  Its functions include lymphocyte production, blood cell storage, and blood cell destruction.
C12433	Thymus_Gland	Organ	Thymus Gland|Reticuloendothelial System, Thymus|Thymus|Thymus Proper|thymus	An organ that is part of the lymphatic system, in which T lymphocytes grow and multiply. The thymus is in the chest behind the breastbone.
C12434	Blood	Body_Fluid_or_Substance	Blood|Peripheral Blood|Reticuloendothelial System, Blood|peripheral blood	Blood circulating throughout the body.
C12435	Muscle_Tissue	Soft_Tissue	Muscle Tissue|Muscle	Tissue responsible for the body movements and the shape and size changes of interna organs.  Muscle tissue is composed of specialized contractile cells.  There are two types of muscle tissue recognized:striated and smooth muscle.  The striated muscle tissue is further subdivided into skeletal, visceral striated, and cardiac muscle.
C12436	Striated_Muscle_Tissue	Muscle_Tissue	Striated Muscle Tissue|Striated Muscle	Striated muscles are appendicular and axial muscles typically connected at either or both ends to the bony skeleton of the body.  Striated muscle fibers contain a highly organized, contractile cytoskeletal apparatus with a striated microscopic appearance; muscle contraction is typically under voluntary control.
C12437	Smooth_Muscle_Tissue	Muscle_Tissue	Smooth Muscle Tissue|Smooth Muscle
C12438	Central_Nervous_System	Nervous_System_Part	Central Nervous System|CNS|Nervous System, CNS|central nervous system	The brain and spinal cord.
C12439	Brain	Central_Nervous_System_Part|Organ	Brain|Brain, Nervous System|Nervous System, Brain	That part of the central nervous system that includes all the higher nervous centers; enclosed within the skull; continuous with the spinal cord.
C12440	Amygdala	Brain_Part	Amygdala	An almond-shaped group of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe. The amygdala is part of the limbic system. (MeSH)
C12441	Brain_Stem	Brain_Part	Brain Stem|brain stem	The part of the brain that is connected to the spinal cord.
C12442	Medulla_Oblongata	Brain_Part	Medulla Oblongata|Myelencephalon	The lower portion of the brainstem located between the pons and brainstem.  This structure contains several descending and ascending tracts, lower cranial nerve nuclei, a significant proportion of the reticular system of the brainstem and other structures.
C12443	Cortex	Brain_Part	Cerebral Cortex|Cortex
C12444	Hippocampus	Brain_Part	Hippocampus	a layer of gray matter lying along the floor of the lateral ventricle of the brain, comprised of cholinergic and possibly glutamatergic fibers, believed to be the critical brain structure underlying learning and memory.
C12445	Cerebellum	Brain_Part	Cerebellum|cerebellum	(sair-uh-BELL-um) The portion of the brain in the back of the head between the cerebrum and the brain stem. The cerebellum controls balance for walking and standing, and other complex motor functions.
C12446	Corpus_Callosum	White_Matter	Corpus Callosum	the main neocortical commissure of the cerebral hemispheres; it is subdivided into a genu, a rostrum, a body, and a splenium.
C12447	Basal_Ganglia	Brain_Part	Basal Ganglia	Large subcortical nuclear masses derived from the telencephalon and located in the basal regions of the cerebral hemispheres. (MeSH)
C12448	Corpus_Striatum	Brain_Part	Corpus Striatum|Striate Body|Striatum	Striped gray and white matter consisting of the neostriatum and paleostriatum (globus pallidus). It is located in front of and lateral to the thalamus in each cerebral hemisphere. The gray substance is made up of the caudate nucleus and the lentiform nucleus. The white matter is the internal capsule. (MeSH)
C12449	Globus_Pallidus	Brain_Part	Globus Pallidus	The representation of the phylogenetically oldest part of the corpus striatum called the paleostriatum. It forms the smaller, more medial part of the lentiform nucleus. (MeSH)
C12450	Striatum	Retired_Concepts	Striatum
C12451	Caudate_Nucleus	Brain_Part	Caudate Nucleus|Nucleus Caudatus	An elongated gray mass of the neostriatum located adjacent to the lateral ventricle of the brain. (MeSH)
C12452	Putamen	Brain_Part	Putamen	The largest and most lateral of the basal ganglia lying between the lateral medullary lamina of the globus pallidus and the external capsule. It is part of the neostriatum and forms part of the lentiform nucleus along with the globus pallidus. (MeSH)
C12453	Substantia_Nigra	Gray_Matter	Substantia Nigra	A large cell mass extending forward, over the dorsal surface of the crus cerebri, from the rostral border of the pons into the subthalamic region. It is composed of a dorsal stratum of closely spaced pigmented cells, the pars compacta, and a larger ventral region of widely scattered cells, the pars reticulata. The pars compacta includes numerous cells that project forward to the striatum (caudate nucleus and putamen) and contain dopamine, which acts as the primary neurotransmitter at the synaptic endings. Other, apparently non-dopaminergic cells project to portions of the ventral nucleus of thalamus, the superior colliculus and reticular formation. The nigrostriatal projection is reciprocated by a striatonigral fiber system with multiple neurotransmitters, chief among which is gamma-aminobutyric acid (GABA). The substantia nigra is involved in the metabolic disturbances associated with Parkinson's disease and Huntington's disease.
C12454	Subthalamic_Nucleus	Brain_Part	Subthalamic Nucleus	Lens-shaped structure on the inner aspect of the internal capsule. The subthalamic nucleus and pathways traversing this region are concerned with the integration of somatic motor function. (MeSH)
C12455	Prosencephalon	Brain_Part	Prosencephalon	The part of the brain developed from the most rostral of the three primary vesicles of the embryonic neural tube and consisting of the diencephalon and telencephalon. (MeSH)
C12456	Diencephalon	Brain_Part	Diencephalon
C12457	Epithalamus	Brain_Part	Epithalamus	The dorsal posterior subdivision of the diencephalon. The epithalamus is generally considered to include the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle. (MeSH)
C12458	Hypothalamus	Brain_Part	Hypothalamus|hypothalamus	(hye-po-THAL-uh-mus) The area of the brain that controls body temperature, hunger, and thirst.
C12459	Thalamus	Brain_Part	Thalamus|thalamus	(THAL-a-muss) An area of the brain that helps process information from the senses and transmit it to other parts of the brain.
C12460	Tectum_Mesencephali	Brain_Part	Tectum Mesencephali
C12461	Corpora_Quadrigemina	Brain_Part	Corpora Quadrigemina
C12462	Dorsal_Root_Ganglion	Ganglion	Dorsal Root Ganglion	Sensory ganglia located on the dorsal spinal roots within the vertebral column. (MeSH)
C12463	Notochord	Other_Embryologic_Structure	Notochord	The rod-shaped body, composed of cells derived from the mesoblast and defining the primitive axis of the embryo. In higher vertebrates it is replaced by the vertebral column. (MeSH)
C12464	Spinal_Cord	Central_Nervous_System_Part|Organ	Spinal Cord|Medulla Spinalis	The elongated, approximately cylindrical part of the central nervous system of vertebrates that lies in the vertebral canal and from which the spinal nerves emerge. (On-line Medical Dictionary)
C12465	Peripheral_Nervous_System	Nervous_System_Part	Peripheral Nervous System	The peripheral nervous system or PNS, is part of the nervous system, and consists of the nerves and neurons that reside or extend outside the central nervous system. (from Wikipedia)
C12466	Nerve	Nervous_System_Part	Nerve|NRV|Nervous	Part of the peripheral nervous system composed of bundles of nerve fibers running to various organs and tissues of the body using chemical and electrical signals to transmit sensory and motor information from one body part to another.
C12467	Sympathetic_Ganglion	Autonomic_Ganglion	Sympathetic Ganglion	Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia. (MeSH)
C12468	Lung	Organ	Lung|Lungs|Respiratory System, Lung	One of a pair of viscera occupying the pulmonary cavities of the thorax, the organs of respiration in which aeration of the blood takes place. As a rule, the right lung is slightly larger than the left and is divided into three lobes (an upper, a middle, and a lower or basal), while the left has two lobes (an upper and a lower or basal). Each lung is irregularly conical in shape, presenting a blunt upper extremity (the apex), a concave base following the curve of the diaphragm, an outer convex surface (costal surface), an inner or mediastinal surface (mediastinal surface), a thin and sharp anterior border, and a thick and rounded posterior border.
C12469	Pleural_Tissue	Membrane	Pleura|PLRA|Pleural Tissue|pleura	(PLOOR-a) A thin layer of tissue covering the lungs and the wall of the chest cavity to protect and cushion the lungs. A small amount of fluid that acts as a lubricant allows the lungs to move smoothly in the chest cavity during breathing.
C12470	Skin	Organ	Skin|Integument	An organ that constitutes the external surface of the body.  It consists of the epidermis, dermis, and skin appendages.
C12471	Soft_Tissue	Connective_and_Soft_Tissue	Soft Tissue|soft tissue	Refers to muscle, fat, fibrous tissue, blood vessels, or other supporting tissue of the body.
C12472	Adipose_Tissue	Soft_Tissue	Adipose Tissue|Body Fat|adipose	Connective tissue composed of fat cells lodged in the meshes of areolar tissue. (MeSH)
C12473	Synovial_Membrane	Connective_and_Soft_Tissue|Membrane	Synovial Membrane|Synovium	The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes synovial fluid. (MeSH)
C12474	B-Lymphocyte	Lymphocyte	B-Lymphocyte|B Cell|B Cells|B Lymphocytes|B cells|B lymphocytes|B-Cell|B-Cells|B-Lymphocytes|Bursa-Dependent Lymphocytes|Bursa-Equivalent Lymphocyte	Immunologically important lymphocyte that is not thymus-dependent, is either short-lived and naive or long-lived and of memory phenotype, and resembles the bursa-derived lymphocyte of birds in that it is responsible for the production of immunoglobulins.
C12475	Basal_Cell	Cell_of_the_Epidermis|Epithelial_Cell	Basal Cell|BC|Basal Cells|basal cells	(BAY-sal) Small, round cells found in the lower part (or base) of the epidermis, the outer layer of the skin.
C12476	T-Lymphocyte	T-Lymphocyte_and_Natural_Killer_Cell	T-Lymphocyte|T Cell|T Cells|T cell|T-Cell|T-Cells|T-Lymphocytes|Thymus-Dependent Lymphocytes|thymus derived lymphocyte	A thymocyte-derived lymphocyte of immunological importance that is long-lived (months to years) and is responsible for cell-mediated immunity. T lymphocyte cells form rosettes with sheep erythrocytes and, in the presence of transforming agents (mitogens), differentiate and divide. These cells have the characteristic T3 surface marker and may be further divided into subsets according to function, such as helper, cytotoxic, etc.
C12477	Astrocyte	Glial_Cell	Astrocyte|Astrocytes|Astrocytus|Astroglia|astrocyte	(AS-troe-site) A type of cell in the brain and spinal cord. An astrocyte is a small, star-shaped glial cell (a cell that surrounds and supports nerve cells).
C12478	Clear_Cell	Glandular_Cell	Clear Cell|Clear Cells	A cell with empty-appearing cytoplasm when viewed with a light microscope.
C12479	Ductal_Epithelial_Cell	Glandular_Cell	Ductal Epithelial Cell|Ductal Cell|Ductal Cells	A stratified columnar epithelial cell that surrounds a lumen in a gland such as the breast, pancreas or prostate. These cells are uniform in appearance and have uniformly sized and shaped nuclei.
C12480	Terminal_Ductal_Lobular_Unit	Mammary_Gland_Tissue	Terminal Ductal Lobular Unit|TDLU|Terminal Ductal Lobular Units
C12481	Endothelium	Soft_Tissue	Endothelium	The layer of cells that lines the cavities of the heart and of the blood vessels (Endothelium, Vascular) and lymph vessels (Endothelium, Lymphatic), and the serous cavities of the body, originating from the mesoderm.
C12482	Fibroblast	Connective_and_Soft_Tissue_Cell	Fibroblast|Fibroblasts|fibroblast	A connective tissue cell that makes and secretes collagen proteins.
C12483	Granular_Cell	Retired_Concepts	Granular Cell
C12484	Large_Cell	Retired_Concepts	Large Cell
C12485	Neuroendocrine_Cell	Endocrine_Cell_and_Neuroendocrine_Cell	Neuroendocrine Cell|Neuroendocrine Cells	An endocrine cell that produces and releases hormones and regulatory proteins such as neurotransmitters and neuropeptide hormones. This type of cell enables autocrine communication with paracrine and endocrine cells throughout the body.
C12486	Plasma_Cell	Mature_B-Lymphocyte	Plasma Cell|Blood Plasma Cell|Plasma Cells|Plasmacytes|Plasmocyte|plasma cells	A type of white blood cell that produces antibodies.
C12487	Signet_Ring_Cell	Abnormal_Cell	Signet Ring Cell
C12488	Small_Cell	Retired_Concepts	Small Cell|Small Cells
C12489	Spindle_Cell	Retired_Concepts	Spindle Cell
C12490	Stroma	Retired_Concepts	Stroma	The supporting connective tissue of an organ.
C12491	Intrathoracal	Anatomy_Modifier	Intrathoracal
C12492	Intra-abdominal	Anatomy_Modifier	Intra-abdominal	Within the abdomen.
C12493	Base_of_the_Skull	Musculoskeletal_System_Part	Base of the Skull|Base of Skull
C12494	Clivus	Musculoskeletal_System_Part	Clivus	The sloping surface from the dorsum sellae to the foramen magnum composed of part of the body of the sphenoid and part of the basal part of the occipital bone. (On-line Medical Dictionary)
C12495	Foramen_Magnum	Musculoskeletal_System_Part	Foramen Magnum
C12496	Jugular_Foramen	Musculoskeletal_System_Part	Jugular Foramen|Posterior Lacerate Foramen
C12497	Sella_Turcica	Musculoskeletal_System_Part	Sella Turcica|sella turcica	A bony prominence situated on the upper surface of the body of the sphenoid bone housing the pituitary gland.
C12498	External_Acoustic_Meatus	Ear_Part	External Acoustic Meatus|Auditory Canal, External|External Auditory Canal	That part of the ear canal external to the ear drum
C12499	Internal_Ear	Ear_Part	Internal Ear|Inner Ear|Labyrinth	The portion of the ear located within the temporal bone that is involved in both hearing and balance and includes the semicircular canals, vestibule, and cochlea. (from American Heritage Dictionary online)
C12500	Eustachian_Tube	Ear_Part	Eustachian Tube|Auditory Tube|Pharyngotympanic Tube|Tuba Auditoria	A tubular structure that runs from the middle ear to the nasopharynx and is approximately 3-4 cm length. Its lumen is roughly triangular and has average diameter of 2-3 mm. The lumen is lined by ciliated pseudostratified, columnar epithelium, which sweeps material from the middle ear to the nasopharynx.  functionally collapsed at rest, with slight negative pressure present in the middle ear. It is closed at rest and opens during swallowing, sneezing, and yawning.  It serves to ventilate pressure differences between the middle ear and nasopharynx. This tube also allows middle ear secretions to drain into the nasopharynx.
C12501	Internal_Auditory_Canal	Retired_Concepts	Internal Auditory Canal|Internal Auditory Meatus
C12502	Tympanic_Membrane	Mucosa	Tympanic Membrane|Ear Drum|Eardrum|Membrana Tympanica|Membrane, Tympanic|TM|TM - Tympanic Membrane	A thin membrane that separates the external auditory canal from the middle ear.  The movement of the tympanic membrane in response to air pressure changes in the external ear facilitates the transmission of sound energy by causing vibration of the ossicular chain.
C12503	Mastoid_Process	Musculoskeletal_System_Part	Mastoid Process|Mastoid|Process Mastoideus	A honeycombed section of bone located near the base of the skull, protruding behind the outer ear.  It is connected to the middle ear.
C12504	Buccal_Cavity	Retired_Concepts	Buccal Cavity|Head and Neck, Buccal Cavity|Oral Cavity	The region consisting of the vestibulum oris, the narrow cleft between the lips and cheeks, and the teeth and gums, and the cavitas oris propria.
C12505	Buccal_Mucosa	Mucosa	Buccal Mucosa|buccal mucosa	(BUK-ul myoo-KO-sa) The inner lining of the cheeks and lips.
C12506	Tooth	Head_and_Neck_Part	Tooth|Teeth	is an organ, the organ parts of which primarily consist of dentine and dental enamel; together with other teeth it constitutes a subdivision of the facial skeleton. Example(s): incisor, molar.
C12507	Mantle_Field	Other_Anatomic_Concept	Mantle Field|mantle field	(MAN-tul) The area of the neck, chest, and lymph nodes in the armpit that are exposed to radiation.
C12508	Cell	Microanatomy	Cell|Cell Type|Cell Types|Cells|Normal Cell|cell	The individual unit that makes up all of the tissues of the body. All living things are made up of one or more cells.
C12509	Infratentorial_Brain	Brain_Part	Infratentorial Brain|Infratentorial Anatomy|Infratentorial Nervous System
C12510	Mesencephalon	Brain_Part	Mesencephalon|Mid-brain|Midbrain	The uppermost portion of the brainstem located between the pons and the diencephalon.  The midbrain contains the cerebral peduncles, oculomotor, trochlear and red nuclei, substantia nigra and various other nuclei and tracts.
C12511	Pons_Varolii	Brain_Part	Pons Varolii|Pons|Pons Cerebelli|pons	Part of the central nervous system, located at the base of the brain, between the medulla oblongata and the midbrain. It is part of the brainstem.
C12512	Supratentorial_Brain	Brain_Part	Supratentorial Brain|Supratentorial Anatomy|Supratentorial Nervous System	(seh-REE-brum) The largest part of the brain. It is divided into two hemispheres, or halves, called the cerebral hemispheres. Areas within the cerebrum control muscle functions and also control speech, thought, emotions, reading, writing, and learning.
C12513	Sagittal_Sinus	Venous_Sinus	Sagittal Sinus
C12514	Inferior_Sagittal_Sinus	Sagittal_Sinus	Inferior Sagittal Sinus|Lesser Sagittal Sinus|Sagittal Sinus, Inferior|Sagittal Sinus, Lesser	An intracranial venous sinus that lies in a midline location along the lower free border of the falx cerebri of the brain. The sinus receives blood from the great cerebral vein and joins the superior sagittal sinus posteriorly.
C12515	Superior_Sagittal_Sinus	Sagittal_Sinus	Superior Sagittal Sinus|Greater Sagittal Sinus|Sagittal Sinus, Greater|Sagittal Sinus, Superior	An intracranial venous sinus that lies in a superior and midline location above the interhemispheric fissure along the superior border of the falx cerebri of the brain. The sinus receives blood from the cerebral veins and drains posteriorly into the lateral sinuses of the brain, which in turn drain into the internal jugular veins.
C12516	Intracranial_Nervous_System	Retired_Concepts	Intracranial Nervous System|Intracranial Anatomy|Intracranial Compartment Components	The brain, intracranial portions of the cranial nerves, intracranial blood vessels, intracranial meninges and other surrounding and supporting structures contained with the skull cavity.
C12517	Intraspinal_Nervous_System	Retired_Concepts	Intraspinal Nervous System
C12518	Blastomere	Embryonic_Cell|Totipotent_Stem_Cell	Blastomere|Blastocytes|Blastomeres|Embryo stage 2	The undifferentiated cells formed by cleavage of the fertilized ovum. This includes cells in the cleavage, morula, and blastula stages of the embryo. (MeSH)
C12519	Peripheral_Blood_Cell	Hematopoietic_Cell	Peripheral Blood Cell|Blood Cell|Blood Cells	A general term describing the three cellular components of blood (white blood cells, red blood cells, and platelets), all which are made in the bone marrow. (Lymphoma Information Network Glossary)
C12520	Platelet	Peripheral_Blood_Cell	Platelet|Bizzozero's corpuscle/cell|Blood Platelet|Blood Platelets|Deetjeen's body|Hayem's elementary corpuscle|Marrow platelet|PLT|PLT - Platelet|Platelets|Reticuloendothelial System, Platelets|Thrombocyte|Thrombocyte/Platelet|Thrombocytes|platelets|thrombocytes	Blood cells that help prevent bleeding by causing blood clots to form.
C12521	Erythrocyte	Peripheral_Blood_Cell	Erythrocyte|Blood erythrocyte|Blood normocyte|Erythrocytes|Erythrocytic|RBC|RBC - Red blood cell|Red Blood Cells|Red Cell|Red blood corpuscule|Red cell of marrow|Red cells|Reticuloendothelial System, Erythrocytes|blood corpuscles|erythrocytes|red blood cell	(eh-RITH-ro-sites) Cells that carry oxygen to all parts of the body.
C12522	Abnormal_Red_Blood_Cell	Abnormal_Hematopoietic_Cell	Abnormal Red Blood Cell
C12523	Acanthocyte	Abnormal_Red_Blood_Cell	Acanthocyte|Acanthocytes|Crenated cell|Spur Cell	Erythrocytes with protoplasmic projections giving the cell a thorny appearance. (MeSH)
C12524	Megaloblast	Dysplastic_Erythroid_Precursor	Megaloblast
C12525	Spherocyte	Abnormal_Red_Blood_Cell	Spherocyte|Spherocytes	Small, abnormal spherical red blood cells with more than the normal amount of hemoglobin. (MeSH)
C12526	Erythroid_Progenitor_Cell	Myeloid_Progenitor_Cell	Erythroid Stem Cell|BFU-E|BFU-E - Burst-form unit eryth|BFU-E - Burst-forming unit erythroid|Burst-Forming Units, Erythroid|CFU-E|Colony-Forming Units, Erythroid|Erythroid Precursor Cells|Erythroid Progenitor Cell|Erythroid Progenitor Cells|Erythropoietic Stem Cells|Progenitor Cells, Erythropoietic|Stem Cells, Erythroid	Committed, erythroid stem cells derived from myeloid stem cells. The progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E). BFU-E differentiate into CFU-E on stimulation by erythropoietin, and then further differentiate into erythroblasts when stimulated by other factors. (MeSH)
C12527	Erythroblast	Myeloid_Cell	Erythroblast|ERYTB|Erythroblasts|Erythrocytes, Nucleated|NUCLEATED RBCS|Normoblasts|Nucleated red blood cell|Nucleated red cell	Immature, nucleated erythrocytes occupying the stage of erythropoiesis that follows formation of erythroid progenitor cells and precedes formation of reticulocytes. Popularly called normoblasts. (MeSH)
C12528	Polychromatophilic_Erythrocyte	Erythrocyte	Reticulocyte|Blood reticulocyte|Diffusely basophilic erythrocyte|Marrow reticulocyte|Polychromatophilic Erythrocyte|Polychromatophilic erythrocyte|Reticulocytes	Immature erythrocytes that have just undergone extrusion of their cell nucleus. They still contain some organelles that gradually decrease in number as the cells mature.
C12529	Leukocyte	Peripheral_Blood_Cell	Leukocyte|Blood leukocyte|Leukocytes|Marrow leukocyte|Reticuloendothelial System, Leukocytes|WBC|WBC - White blood cell|White Blood Cell|White Blood Cells|White Cell|leukocytes|white blood cell|white blood corpuscle	(LOO-ko-sites) White blood cell. Refers to a blood cell that does not contain hemoglobin. White blood cells include lymphocytes, neutrophils, eosinophils, macrophages, and mast cells. These cells are made by bone marrow and help the body fight infection and other diseases.
C12530	Granulocyte	Myeloid_Cell	Granulocyte|Blood granulocytic cell|GRA|Granular Leukocytes|Granulocytes|Granulocytic cell|granular leukocyte	A leucocyte with conspicuous cytoplasmic granules. In humans the granulocytes are also classified as polymorphonuclear leucocytes and are subdivided according to the staining properties of the granules into eosinophils, basophils and neutrophils. (from On-line Medical Dictionary)
C12531	Basophil	Leukocyte	Basophil|BAS|Basophilic Granulocyte|Basophilic Leukocyte|Basophils|Blood Basophil|Marrow Basophil|basophil	A type of granular leukocyte with granules that are easily stained by basic stains.
C12532	Eosinophil	Leukocyte	Eosinophil|Acidophilic Leukocyte|Blood Eosinophil|Blood eosinophil|EOS|Eosinocyte|Eosinophilic Granulocyte|Eosinophilic Leukocyte|Eosinophils|Marrow Eosinophil|eosinophil	A type of white blood cell.
C12533	Neutrophil	Leukocyte	Neutrophil|Blood Neutrophil|Blood PMN|Blood Segmented Neutrophil|Heterophil Granulocyte|Marrow Neutrophil|Neutrophilic Granulocyte|Neutrophilic Leukocyte|Neutrophils|Polymorph|Polymorphonuclear Cell|Polymorphonuclear Leukocytes|Polymorphonuclear Neutrophils|Polymorphonuclear neutrophils|neutrophil	(NOO-tro-fil) A type of white blood cell.
C12534	Non-Granular_Leukocyte	Other_Anatomic_Concept	Non-Granular Leukocyte|Agranulocyte|Leukocyte, Mononuclear|Leukocytes, Mononuclear|Non-Granular Leukocytes|agranulocyte	(A-gran-yoo-lo-SITE) A type of white blood cell; monocytes and lymphocytes are agranulocytes.
C12535	Lymphocyte	Hematopoietic_Cell	Lymphocyte|LYMPH|Lymphocytes|lymph cell|lymphocyte	(LIM-fo-site) A type of white blood cell. Lymphocytes have a number of roles in the immune system, including the production of antibodies and other substances that fight infection and diseases.
C12536	Natural_Killer_Cell	Peripheral_T-Lymphocyte_and_Natural_Killer_Cell	Natural Killer Cell|Cytotoxic cell|K Cells|K lymphocyte|Killer Cell|Killer Cells|Killer Cells, Natural|NK|NK Cell|NK Cells|NK cells|NK-Cell|killer cells|natural killer cells	Natural killer cells are cells that resemble large granular lymphocytes.  They do not express markers of either T or B cell lineage. They are positive for CD16, CD56, and CD 94.  These cells do possess Fc receptors for IgG and can kill target cells using antibody-dependent cell-mediated cytotoxicity. They can also use perforin to kill cells in the absence of antibody and killing may occur without previous sensitization.
C12537	CD4_Plus_T-Lymphocyte	Mature_T-Lymphocyte	CD4-Positive T-Lymphocyte|CD4 lymphocytes|CD4+ T Lymphocyte|CD4+ T Lymphocytes|CD4+ T-Lymphocyte|CD4-Positive Lymphocytes|CD4-Positive T-Lymphocytes|CELLS.CD4|T4 Cells|T4 Lymphocytes|helper T cell	A type of white blood cell that helps stimulate immune system reactions.  Helper T cells help activate cytotoxic T cells and macrophages by secreting cytokines. They also stimulate B cells to make antibodies.
C12538	Helper-Inducer_T-Lymphocyte	CD4_Plus_T-Lymphocyte	Helper-Inducer T-Lymphocyte|Helper Cells|Helper T-Cells|Inducer Cells|T-Cells, Helper-Inducer|T-Lymphocyte, Helper-Inducer|T-Lymphocytes, Helper|T-Lymphocytes, Helper-Inducer|T-Lymphocytes, Inducer	A subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. (MeSH)
C12539	Type_1_Helper_Cell	Helper-Inducer_T-Lymphocyte	Type 1 Helper Cell|Th-1 Cell|Th1 Cell|Th1 Cells	Type 1 Helper Cells are a subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, these cells are associated with delayed-type hypersensitivity reactions.
C12540	Type_2_Helper_Cell	Helper-Inducer_T-Lymphocyte	Type 2 Helper Cell|TH2 Cells|Th-2 Cell|Th2 Cell|Th2 Cells	Type 2 Helper Cells are a subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.
C12541	Suppressor-Inducer_T-Lymphocyte	CD4_Plus_T-Lymphocyte	Suppressor-Inducer T-Lymphocyte|T-Cells, Suppressor-Inducer|T-Lymphocyte, Suppressor-Inducer|T-Lymphocytes, Suppressor-Inducer	Subpopulation of CD4+ lymphocytes which induce CD8+ suppressor T-cells to suppress antibody production by B-cells. They also stimulate other cellular immune responses. (MeSH)
C12542	CD8_Plus_T-Lymphocyte	Mature_T-Lymphocyte	CD8-Positive T-Lymphocyte|CD8 Cell|CD8 Lymphocytes|CD8+ T Lymphocyte|CD8+ T Lymphocytes|CD8+ T-Lymphocyte|CD8-Positive Lymphocytes|CD8-Positive T-Lymphocytes|CELLS.CD8|T8 Cells|T8 Lymphocytes	A subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes and suppressor T-lymphocytes. (MeSH)
C12543	Cytotoxic_T-Lymphocyte	CD8_Plus_T-Lymphocyte	Cytotoxic T-Lymphocyte|CTL|Cell-Mediated Lympholytic Cells|Cytolytic T-Cell|Cytotoxic T Cell|Cytotoxic T Cells|Cytotoxic T-Lymphocytes|T-Lymphocyte, Cytotoxic|T-Lymphocytes, Cytotoxic|cytotoxic T cells	A type of white blood cell that can directly destroy specific cells. T cells can be separated from other blood cells, grown in the laboratory, and then given to a patient to destroy tumor cells. Certain cytokines can also be given to a patient to help form cytotoxic T cells in the patient's body.
C12544	Suppressor-Effector_T-Lymphocyte	CD8_Plus_T-Lymphocyte	Suppressor-Effector T-Lymphocyte|Suppressor Cells|Suppressor T Lymphocyte|T Suppressor Cell|T-Cells, Suppressor-Effector|T-Lymphocyte, Suppressor-Effector|T-Lymphocytes, Suppressor-Effector	Subpopulation of CD8+ T-lymphocytes which suppress antibody production or inhibit cellular immune responses. Suppressor-effector cells execute the message received from suppressor-inducer cells. (MeSH)
C12545	Lymphocyte_Null	Retired_Concepts	Lymphocyte, Null|Lymphocytes, Null|Non-B non-T lymphocyte|Non-T non-B cell|Null Cells	A class of lymphocytes characterized by the lack of surface markers specific for either T or B lymphocytes. (MeSH)
C12546	Tumor_Infiltrating_Lymphocyte	Lymphocyte	Tumor Infiltrating Lymphocyte|Lymphocyte, Tumor-Infiltrating|Lymphocytes, Tumor-Infiltrating|TIL|Tumor Infiltrating Lymphocytes|tumor infiltrating lymphocytes	White blood cells that have left the bloodstream and migrated into a tumor.
C12547	Monocyte	Leukocyte	Monocyte|Blood monocyte|M|Marrow monocyte|Monocytes|monocyte	A type of white blood cell.
C12548	Monocyte_Activated_Killer	Biological_Agent	Monocyte, Activated Killer|Monocytes, Activated Killer	Monocytes made cytotoxic by ex vivo incubation with cytokines, especially interferon-gamma. AKM cells are used for adoptive immunotherapy in cancer patients. (MeSH)
C12549	Myeloid_Cell	Hematopoietic_Cell	Myeloid Cell|Myeloid Cells	Cells which include the monocytes and the granulocytes. (MeSH)
C12550	Bone_Marrow_Blood-Forming_Cell	Bone_Marrow_Stem_Cell	Bone Marrow Blood-Forming Cell|Bone Marrow Blood-Forming Cells|Bone Marrow Cells	Cells contained in the bone marrow including fat cells, stromal cells, mega karyocytes, and the immediate precursors of most blood cells. (MeSH)
C12551	Hematopoietic_Stem_Cell	Hematopoietic_Cell|Stem_Cell	Hematopoietic Stem Cell|Blood Precursor Cell|Ferrata cell|Hematohistioblast|Hematopoietic Progenitor Cells|Hematopoietic Stem Cells|Hemocytoblast|Hemohistioblast|Progenitor Cells, Hematopoietic|Stem Cells	Primitive blood cells derived from embryonic mesenchyme capable of differentiating into any of the blood cell line progenitor cells (erythroblasts, young granulocytic series cells, megakaryocytes, etc.)
C12552	Myeloid_Progenitor_Cell	Bone_Marrow_Stem_Cell	Bone Marrow Myeloid Stem Cell|Myeloid Progenitor Cell|Myeloid Progenitor Cells|Stem Cells, Myeloid	One of the two stem cells derived from hematopoietic stem cells. (MeSH)
C12553	Megakaryocyte	Myeloid_Cell	Megakaryocyte|Blood megakaryocyte|Megakaryocytes|Megalokaryocyte	Very large bone marrow cells which release mature blood platelets.
C12554	Chromaffin_Cell	Neural_Crest-Derived_Cell	Chromaffin Cell|Chromaffin Cells	Cells that store epinephrine secretory vesicles. Characteristically, they are located in the adrenal medulla and paraganglia of the sympathetic nervous system. (MeSH)
C12555	Connective_and_Soft_Tissue_Cell	Cell	Connective and Soft Tissue Cell|Connective Tissue Cell|Connective Tissue Cells	A group of cells that includes fibroblasts, cartilage cells, adipocytes, smooth muscle cells, and bone cells. (MeSH)
C12556	Adipocyte	Lipocyte	Adipocyte|Adipocytes|Adipose Cell|Fat Cell|Fat Cells|Lipocytes|Mature Lipocyte|Mature fat cell	Fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue. (MeSH)
C12557	Chondrocyte	Cartilage_Cell	Chondrocyte|Chondrocytes|chondrocytes	Cartilage cells.  They make the structural components of cartilage.
C12558	Macrophage	Phagocytic_Cell	Macrophage|Histiocyte|Macrophages|Monocytes / Macrophages / APC|macrophage	A type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells.
C12559	Epithelioid_Cell	Phagocytic_Cell	Epithelioid Cell|Epithelioid Cells	Characteristic cells of granulomatous hypersensitivity. They appear as large, flattened cells with increased endoplasmic reticulum. They are believed to be activated macrophages that have differentiated as a result of prolonged antigenic stimulation. Further differentiation or fusion of epithelioid cells is thought to produce multinucleated giant cells. (MeSH)
C12560	Foam_Cell	Macrophage	Foam Cell|Foam Cells	Lipid-laden macrophages originating from monocytes or from smooth muscle cells. (MeSH)
C12561	Foreign_Body_Giant_Cell	Giant_Cell	Foreign Body Giant Cell|Giant Cell, Foreign Body
C12562	Langhans_Cell	Giant_Cell	Langhans Cell|Langhans' - Type Giant Cell
C12563	Histiocyte	Connective_and_Soft_Tissue_Cell|Histiocytic_and_Dendritic_Cell|Macrophage	Histiocyte|Histiocytes	A macrophage present in connective tissue.
C12564	Kupffer_Cell	Macrophage	Kupffer Cell|Kupffer Cells|Kupffer's Cell|Stellate Sinusoidal Macrophage	Large star-shaped or pyramidal cells with a large oval nucleus and a small prominent nucleolus. These intensely phagocytic cells line the walls of the sinusoids of the liver and form a part of the reticuloendothelial system.
C12565	Alveolar_Macrophage	Macrophage	Alveolar Macrophage|Macrophages, Alveolar|Pulmonary Macrophages	Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.
C12566	Peritoneal_Macrophage	Macrophage	Peritoneal Macrophage|Macrophages, Peritoneal	Mononuclear phagocytes derived from bone marrow precursors but resident in the peritoneum. (MeSH)
C12567	Odontoblast	Tooth_Cell	Odontoblast|Odontoblasts	A cell derived from a preodontoblast that secretes predentin. Each odontoblast has a cytoplasmic extension, an odontoblastic process that traverses the thickness of the dentin and helps to maintain the dentin.
C12568	Osteoblast	Bone_Cell	Osteoblast|Osteoblasts	Cells which secrete an extracellular matrix into which hydroxyapaetite crystals are deposited to form bone.
C12569	Osteocyte	Bone_Cell	Osteocyte|Osteocytes	Mature osteoblasts that have become embedded in the bone matrix. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi. (MeSH)
C12570	Osteoclast	Bone_Cell	Osteoclast|Osteoclasts	A large multinuclear cell associated with the absorption and removal of bone. (MeSH)
C12571	Stromal_Cell	Connective_and_Soft_Tissue_Cell	Stromal Cell|Stromal Cells	Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
C12572	Theca_Cell	Connective_and_Soft_Tissue_Cell|Endocrine-Stromal_Cell	Theca Cell|Ovarian Interstitial Cells|Theca Cells	The connective tissue cells of the ovarian follicle. (MeSH)
C12573	Endocrine_Cell_of_the_Gastrointestinal_System	Neuroendocrine_Cell	Endocrine Cell of the Gastrointestinal System|Endocrine Cell of Gut|Endocrine Cells of Gut|Endocrine Cells, Gastrointestinal	Cells found throughout the lining of the gastrointestinal tract that contain regulatory peptide hormones and/or biogenic amines. There are at least 15 different types of endocrine cells of the gut. Some take up amine precursors and have been called APUD cells. However, most endocrine cells of the gut apparently have endodermal rather than neuroectodermal origin, so the relationship with APUD cells is not clear. (MeSH)
C12574	Delta_Cell	Endocrine_Cell_of_the_Gastrointestinal_System	Delta Cell|D Cell|D Cells|Somatostatin Cell|Somatostatin Cells|Somatostatin Secreting Cell	Cells found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. (MeSH)
C12575	Enterochromaffin_Cell	Endocrine_Cell_of_the_Gastrointestinal_System	Enterochromaffin Cell|EC Cell|Enterochromaffin|Enterochromaffin Cells	A group of basal granular cells of the gut whose granules stain readily with silver and chromium salts. The cells secrete serotonin, substance P, and enkephalins. (MeSH)
C12576	Enterochromaffin-Like_Cell	Endocrine_Cell_of_the_Gastrointestinal_System	Enterochromaffin-Like Cell|ECL Cell|ECL Cells|Enterochromaffin-like Cell|Enterochromaffin-like Cells	Irregular-shaped argyrophilic cells which produce histamine, chromogranin A/pancreastatin, and an as yet unidentified peptide hormone. They are the predominant endocrine cell type of the oxyntic (acid-producing) mucosa of the stomach. ECL cells respond to gastrin by releasing their secretory products and this source of histamine acts as the positive paracrine stimulator of the release of hydrochloric acid from the parietal cell. (MeSH)
C12577	G-Cell	Endocrine_Cell_of_the_Gastrointestinal_System	G-Cell|G Cell|G Cells|Gastrin Cell|Gastrin Cells|Gastrin Secreting Cell	Endocrine cells found in the pyloric gland mucosa (antral mucosa) of the stomach and responsible for the secretion of gastrin. (MeSH)
C12578	Epithelial_Cell	Cell	Epithelial Cell|Epithelial Cells	Cells that cover the surface of the body and line its cavities.
C12579	Ameloblast	Tooth_Cell	Ameloblast|Ameloblasts	Cylindrical epithelial cells in the innermost layer of the enamel organ. Their functions include contribution to the development of the dentinoenamel junction by the deposition of a layer of the matrix, thus producing the foundation for the prisms (the structural units of the dental enamel), and production of the matrix for the enamel prisms and interprismatic substance.  (MeSH)
C12580	Chief_Cell	Specialized_Epithelial_Cell	Chief Cell|Chief Cells	Epithelial cells that line the basal half of the gastric glands. They synthesize and secrete pepsinogen, a precursor of the enzyme pepsin. (MeSH)
C12581	Chromatophore	Experimental_Organism_Anatomical_Concepts	Chromatophore|Chromatophores	The large pigment cells of fish, amphibia, reptiles and many invertebrates which actively disperse and aggregate their pigment granules. These cells include melanophores, erythrophores, xanthophores, leucophores and iridiophores. (MeSH)
C12582	Melanophore	Chromatophore	Melanophore|Melanophores	Chromatophores which contain melanin. (MeSH)
C12583	Dendritic_Cell	Antigen_Presenting_Cell|Histiocytic_and_Dendritic_Cell	Dendritic Cell|Dendritic Cells|Veiled Cells|dendritic cell	A special type of antigen-presenting cell (APC) that activates T lymphocytes.
C12584	Langerhans_Cell	Cell_of_the_Epidermis|Dendritic_Cell	Langerhans Cell|Langerhans Cells|Non-Neoplastic Langerhans Cell	Dendritic clear cells in the epidermis, containing distinctive granules that appear rod- or racket-shaped in section, but lacking tonofilaments, melanosomes, and desmosomes; they carry surface receptors for immunoglobulin (Fc) and complement (C3), and are believed to be antigen fixing and processing cells of monocytic origin; active participants in cutaneous delayed hypersensitivity.
C12585	Enterocyte	Glandular_Cell	Enterocyte|Enterocytes	Terminally differentiated cells comprising the majority of the external surface of the intestinal epithelium. Unlike goblet cells, they do not produce or secrete mucins, nor do they secrete cryptdins as do the paneth cells. (MeSH)
C12586	Goblet_Cell	Glandular_Cell|Secretory_Cell	Goblet Cell|Goblet Cells	Cells of the epithelial lining that produce and secrete mucins. (MeSH)
C12587	Granulosa_Cell	Endocrine-Stromal_Cell	Granulosa Cell|Granulosa Cells	Cells of the membrana granulosa lining the vesicular ovarian follicle which become luteal cells after ovulation. (MeSH)
C12588	Hepatocyte	Glandular_Cell	Hepatocyte|Hepatic Cells|Hepatic Parenchymal Cell|Hepatocytes|Liver Cells|hepatocyte	(HEP-a-toe-site) A liver cell.
C12589	Keratinocyte	Skin_Squamous_Cell	Keratinocyte|Keratinocytes	Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
C12590	Supporting_Cell_of_Organ_of_Corti	Cell	Supporting Cell of Organ of Corti|Labyrinth Supporting Cell|Labyrinth Supporting Cells	Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen. (MeSH)
C12591	Melanocyte	Cell_of_the_Epidermis	Melanocyte|Melanocytes|melanocytes	(mel-AN-o-sites) Cells in the skin and eyes that produce and contain the pigment called melanin.
C12592	Merkel_Cell	Cell_of_the_Epidermis|Neuroendocrine_Cell	Merkel Cell|Merkel Cells|Merkel's Receptor	Modified epidermal cells located in the stratum basale. They are found mostly in areas where sensory perception is acute, such as the fingertips. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber. (MeSH)
C12593	Paneth_Cell	Glandular_Cell	Paneth Cell|Paneth Cells	Epithelial cells found in the basal part of the intestinal glands (crypts of Lieberkuhn). Paneth cells synthesize and secrete lysozyme and cryptdins. (MeSH)
C12594	Parietal_Cell	Gastric_Glandular_Cell	Parietal Cell|Oxyntic Cells|Parietal Cells|Parietal Cells, Gastric	Cells of the gastric glands which secrete hydrochloric acid and intrinsic factor. (MeSH)
C12595	Sertoli_Cell	Endocrine-Stromal_Cell	Sertoli Cell|Sertoli Cells|Sustentacular Cell of Testis	Elongated cells in the seminiferous tubules to which spermatids are attached during spermiogenesis; they secrete androgen-binding protein and establish the blood-testis barrier by forming tight junctions with adjacent Sertoli's cells.
C12596	Eukaryotic_Cell	Cell	Eukaryotic Cell|Eukaryotic Cells	Cells of the higher organisms, containing a true nucleus bounded by a nuclear membrane. (MeSH)
C12597	Germ_Cell	Cell	Germ Cell|Gametes|Germ Cells|Germ-Line Cells|Initial Cell|Reproductive Cells|Sex Cell|Sexual Cell|germ cell|reproductive cells	A reproductive cell of the body. Germ cells are egg cells in females and sperm cells in males.
C12598	Egg	Germ_Cell	Oocyte|Egg|Egg, Unfertilized|Oocytes|Ovocytes|Ovum|egg/ovum	The female gamete, germ cells in stages between the prophase of the first maturation division and the completion of the second maturation division.
C12599	Oocyte	Retired_Concepts	Oocyte|Oocytes|Ovocytes|Ovum
C12600	Primary_Oocyte	Egg	Primary Oocyte|Oogonia|Oogonium|Primary oocyte|Primordial ovum	The primitive differentiated female gamete which gives rise to an oocyte. (MeSH)
C12601	Zygote	Embryonic_Cell	Zygote|Egg, Fertilized|Fertilized Egg|Fertilized Ovums|Ovum, Fertilized	The cell formed by the union of two gametes, especially a fertilized ovum before cleavage. (Online Medical Dictionary)
C12602	Spermatozoon	Spermatogenic_Cell	Spermatozoon|Sperm|Spermatozoa|sperm|zoosperm	The male reproductive cell that is formed in the testicle. A sperm consists of a head, a body, and a tail that provides propulsion.
C12603	Head_of_the_Spermatozoon	Male_Reproductive_System_Part	Head of the Spermatozoon|Sperm Head	The anterior, usually ovoid, nucleus-containing part of spermatozoa. (MeSH)
C12604	Spermatid	Spermatogenic_Cell	Spermatid|Spermatids|Spermatoblasts|spermid|spermoblast	Male germ cells derived from spermatocytes and developing into spermatozoa. (MeSH)
C12605	Spermatocyte	Spermatogenic_Cell	Spermatocyte|Spermatocytes|Spermiocytes	Male germ cells derived from spermatogonia and developing into spermatids. (MeSH)
C12606	Spermatogonium	Spermatogenic_Cell	Spermatogonium|Spermatogonia|Spermatogonias|Spermatophores|spermatogone|spermatospore|spermigonium|spermospore	The primitive differentiated male gamete which gives rise to a spermatocyte. (MeSH)
C12607	Giant_Cell	Abnormal_Cell	Giant Cell|Syncytium|syncytium	A large cell-like structure formed by the joining together of two or more cells.  The plural is syncytia.
C12608	Islet_of_Langerhans	Epithelial_Tissue	Islet of Langerhans|B9 ENDOCRINE PANCREAS|Islands of Langerhans|Islet Cells|Islets of Langerhans|Langerhans Islets|Nesidioblasts|Pancreas, Endocrine|Pancreatic Islets|Pars endocrina pancreatis|islets of Langerhans	(EYE-lets of LANG-er-hanz) Cells in the pancreas that produce hormones (including insulin).
C12609	Leydig_Cell	Endocrine-Stromal_Cell	Leydig Cell|Interstitial Cell|Interstitial Cell of Leydig|Interstitial Cell of Testis|Interstitial Cell of the Testis|Interstitial cell of Leydig|Leydig Cells	Cells in the interstitial tissue of the testis that are believed to furnish the internal secretion of that gland. (MeSH)
C12610	Lutein_Cell	Endocrine-Stromal_Cell	Lutein Cell|Luteal Cell|Lutein Cells	The cells of the corpus luteum which are derived from the granulosa cells and the theca cells of the Graafian follicle. (MeSH)
C12611	Antibody_Producing_Cell	Mature_B-Lymphocyte	Antibody Producing Cell|Antibody-Producing Cell|Antibody-Producing Cells|Immunoglobulin-Producing Cells	Cells of the lymphoid series that can react with antigen to produce specific cell products called antibodies. (MeSH)
C12612	Muscle_Cell	Connective_and_Soft_Tissue_Cell	Muscle Cell|Muscle Cells|Myocyte	A connective tissue cell with the ability to convert chemical energy into mechanical energy via a contractile apparatus. As part of the contractile apparatus, the proteins actin and myosin form parallel myofilaments. The interaction of actin and myosin mediates muscle cell contraction in response to stimulation of the excitable cell membrane.
C12613	Muscle_Fibers_Fast-Twitch	Other_Anatomic_Concept	Muscle Fibers, Fast-Twitch|Muscle Fibers, Type II|Skeletal muscle fiber, type II	Skeletal muscle fibers having high myofibrillar ATPase activity, high glycolytic enzyme activities, and an intermediate glycogen content which produce a fast twitch. There are two types. Fast fatigable fibers, also called white fibers, have a low myoglobin content, and a small mitochondrial content, and fatigue rapidly due to their limited glycogen content and low capacity for oxidative metabolism. Fast fatigue-resistant fibers, also called red fibers, have a large mitochondrial content and a high myoglobin content, related to their resistance to fatigue. (MeSH)
C12614	Muscle_Fibers_Slow-Twitch	Other_Anatomic_Concept	Muscle Fibers, Slow-Twitch|Muscle Fibers, Intermediate|Muscle Fibers, Type I|Skeletal muscle fiber, type I	Skeletal muscle fibers having low myofibrillar ATPase activity, low glycogen content, and high myoglobin content, high mitochondrial oxidative enzyme activities, and an intermediate mitochondrial content which produce a slow twitch and are fatigue-resistant. (MeSH)
C12615	Glial_Cell	Neuroepithelial_Cell|Supporting_Cell_of_the_Nervous_System	Glial Cell|Glia|Glial Cells|Kolliker's reticulum|Neuroglia|Neuroglial Cells|Non-neuronal cell|glial cell|nerve cement	(GLEE-al) A type of cell that surrounds nerve cells and holds them in place.  Glial cells also insulate nerve cells from each other.
C12616	Microglia	Phagocytic_Cell	Microglia|Gitter cell|Hortega cell|Microgliocyte|mesoglia|microglial cell|perivascular glial cell	A type of glial cell. Microglia are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling. (MeSH)
C12617	Neuropil	Gray_Matter	Neuropil	A dense intricate feltwork of interwoven fine glial processes, fibrils, synaptic terminals, axons, and dendrites interspersed among the nerve cells in the gray matter of the central nervous system. (MeSH)
C12618	Oligodendroglia_Cell	Glial_Cell	Oligodendrocyte|Oligodendrocytes|Oligodendrocytus|Oligodendroglia|Oligodendroglia Cell	A class of neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal satellite cells according to their location. The most important recognized function of these cells is the formation of the insulating myelin sheaths of axons in the central nervous system. (MeSH)
C12619	Perineuronal_Satellite_Cell	Satellite_Cell	Perineuronal Satellite Cell	A flattened non-neuronal cell surrounding a ganglion cell.
C12620	Schwann_Cell	Connective_and_Soft_Tissue_Cell|Perineural_Cell	Schwann Cell|Neurilemma Cell|Neurilemmal Cell|Schwann Cells|Schwann cell	A type of glial cell of the peripheral nervous system that helps separate and insulate nerve cells.
C12621	Antigen_Presenting_Cell	Cell	Antigen Presenting Cell|APC|Accessory Cell|Antigen Presenting Cells|Antigen-Presenting Cell|Antigen-Presenting Cells|Immunologic Accessory Cells|antigen-presenting cell	APC. A cell that shows antigen on its surface to other cells of the immune system. This is an important part of an immune response.
C12622	Follicular_Dendritic_Cell	Dendritic_Cell	Follicular Dendritic Cell|Dendritic Cells, Follicular|Follicular Dendritic Cells	Antigen Presenting Cells (APCs) located in the follicles of secondary lymphoid organs.  These dendritic cells are unique because of their location, primarily in lymphoid follicles, and because of their function in retaining antigen molecules for extended periods of time and serving as APCs for B cells.
C12623	Neuron	Neuron_and_Supporting_Cell_of_the_Nervous_System	Neuron|Nerve Cell|Nerve Cells|Nerve Unit|Neural Cell|Neurocyte|Neurons|nerve cell|neuron	A type of cell that receives and sends messages from the body to the brain and back to the body. The messages are sent by a weak electrical current.
C12624	Preganglionic_Autonomic_Fiber	Axon	Preganglionic Autonomic Fiber|Autonomic Fibers, Preganglionic|preganglionic fiber	Nerve fibers which project from the central nervous system to autonomic ganglia. In the sympathetic division most preganglionic fibers originate with neurons in the intermediolateral column of the spinal cord, exit via ventral roots from upper thoracic through lower lumbar segments, and project to the paravertebral ganglia; there they either terminate in synapses or continue through the splanchnic nerves to the prevertebral ganglia. In the parasympathetic division the fibers originate in neurons of the brain stem and sacral spinal cord. In both divisions the principal transmitter is acetylcholine but peptide cotransmitters may also be released. (MeSH)
C12625	Interneuron	Multipolar_Neuron	Interneuron|Connector Neuron|Intercalary Neuron|Intercalated Neuron|Intercalated Neurons|Interneurons|Internuncial Cell|Internuncial Neuron	A general term for any neurons which are not motor or sensory. Interneuron may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions. (from MeSH)
C12626	Amacrine_Cell	Interneuron	Amacrine Cell|Amacrine Cells|Amacrine Cells of Retina	A retinal neuron that lacks large axons, having only processes that resemble dendrites.
C12627	Myelinated_Nerve_Fiber	Axon	Myelinated Nerve Fiber|Nerve Fibers, Myelinated	Axons of neurons encased in a lipoproteinaceous material called myelin. (MeSH)
C12628	Sensory_Neuron	Neuron	Sensory Neuron|Afferent Neuron|Neurons, Afferent|Neurons, Sensory|Sensory Cell Afferent Neuron	Neurons which convey sensory information centrally from the periphery. (MeSH)
C12629	Hair_Cell	Mechanoreceptor_Cell|Sensory_Neuron	Hair Cell|Corti Cell|Ear Hair Cell|Hair Cells	Mechanoreceptors located in the organ of Corti that are sensitive to auditory stimuli and in the vestibular apparatus that are sensitive to movement of the head. In each case the accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system. (MeSH)
C12630	Type_I_Hair_Cell	Hair_Cell	Type I Hair Cell|Hair Cells, Inner|Inner Hair Cell	Bulbous cells that are medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated. (MeSH)
C12631	Type_II_Hair_Cell	Hair_Cell	Type II Hair Cell|Hair Cells, Outer|Outer Hair Cell	Mechanoreceptors in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea. (MeSH)
C12632	Vestibular_Hair_Cell	Hair_Cell	Vestibular Hair Cell|Equilibrium Hair Cell|Hair Cells, Vestibular	Mechanoreceptors located in the acoustic maculae and the semicircular canals that mediate the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the vestibulocochlear nerve to the brain stem. (MeSH)
C12633	Olfactory_Receptor_Neuron	Sensory_Neuron	Olfactory Receptor Neuron|Olfactory Receptor Neurons	Neurons in the olfactory epithelium with receptors that bind, and thus detect, odorants. Unlike other neurons, they can be generated from precursor cells in adults. (MeSH)
C12634	Photoreceptor_Cell	Sensory_Neuron	Photoreceptor Cell|Photoreceptor|Photoreceptors|Photosensitive Cell|Visual Receptor	Cells specialized to detect and transduce light. (MeSH)
C12635	Photoreceptors_Invertebrate	Other_Anatomic_Concept	Photoreceptors, Invertebrate	Cells in invertebrates which are specialized to detect and transduce light and darkness and relay that information centrally in the nervous system. (MeSH)
C12636	Photoreceptors_Vertebrate	Retired_Concepts	Photoreceptors, Vertebrate|Rods and Cones	Cells specialized to detect and transduce light. Rods and cones are the photoreceptors in the vertebrate retina. (MeSH)
C12637	Cone	Photoreceptor_Cell	Cone|Cone Cell|Cones|Cones (Eye)|Cones (Retina)|Photoreceptors, Cone|Retinal Cone	One of the two photoreceptor cell types in the vertebrate retina. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision. (MeSH)
C12638	Rod	Photoreceptor_Cell	Rod|Rod Cell|Rod Photoreceptors|Rods|Rods (Eye)|Rods (Retina)	One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision. (MeSH)
C12639	Rod_Outer_Segment	Other_Anatomic_Concept	Rod Outer Segment|ROS (rod outer segment)|Rod Outer Segment of the Retina|Rod Outer Segments	A portion of the retinal rod cell largely consisting of a stack of discs (membrane infoldings that are incompletely separated in cones) that are continually replenished near the inner segment and that are shed from the distal end and phagocytosed by the pigmented epithelium.
C12640	Posterior_Horn_Cell	Sensory_Neuron	Posterior Horn Cell|Dorsal Horn Cells|Neurons, Dorsal Horn|Neurons, Posterior Horn|Posterior Horn Cells	Neurons in the posterior (dorsal) horn of the spinal cord whose cell bodies and processes are confined entirely to the central nervous system. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to anterior horn cells or to the white matter ascending and descending longitudinal fibers.
C12641	Substantia_Gelatinosa	Spinal_Cord_Part	Substantia Gelatinosa|Substantia Gelatinosa of Rolando	Gelatinous-appearing material in the dorsal horn of the spinal cord, consisting chiefly of Golgi type II neurons and some larger nerve cells. (MeSH)
C12642	Retinal_Ganglion_Cell	Ganglion_Cell	Retinal Ganglion Cell|Ganglion Cells (Retina)|Retinal Ganglion|Retinal Ganglion Cells	Cells of the innermost nuclear layer of the retina, the ganglion cell layer, which project axons through the optic nerve to the brain. (MeSH)
C12643	Efferent_Neuron	Neuron	Efferent Neuron|Efferent Nerve|Neurons, Efferent	Neurons which send impulses peripherally to activate muscles or secretory cells. (MeSH)
C12644	Motor_Neuron	Multipolar_Neuron|Sensory-Somatic_Nervous_System	Motor Neuron|Efferent Neuron|Motoneuron|Motor Cell|Motor Neurons	Neurons which activate muscle cells. (MeSH)
C12645	Anterior_Horn_Cell	Motor_Neuron	Anterior Horn Cell|Anterior Horn Cells|Neurons, Anterior Horn|Ventral Horn Cells|Ventral Horn Neurons	Motor neurons in the anterior (ventral) horn of the spinal cord which project to skeletal muscles. (MeSH)
C12646	Gamma_Motor_Neuron	Motor_Neuron	Gamma Motor Neuron|Motor Neurons, Gamma|Motor Neurons, Gamma-Efferent|Neurons, Fusimotor	Motor neurons which activate the contractile regions of intrafusal muscle fibers, thus adjusting the sensitivity of the muscle spindles to stretch. (MeSH)
C12647	Nitrergic_Neuron	Neuron	Nitrergic Neuron|Nitrergic Neurons|Nitroxidergic Neurons	A nerve cell that uses nitric oxide as its neurotransmitter.
C12648	Postganglionic_Autonomic_Fiber	Axon	Postganglionic Autonomic Fiber|Autonomic Fibers, Postganglionic|postganglionic fiber	Nerve fibers which project from cell bodies of autonomic ganglia to synapses on target organs. (MeSH)
C12649	Postganglionic_Parasympathetic_Fiber	Postganglionic_Autonomic_Fiber	Postganglionic Parasympathetic Fiber|Parasympathetic Fibers, Postganglionic	Nerve fibers which project from parasympathetic ganglia to synapses on target organs. Parasympathetic postganglionic fibers use acetylcholine as transmitter. They may also release peptide cotransmitters. (MeSH)
C12650	Postganglionic_Sympathetic_Fiber	Postganglionic_Autonomic_Fiber	Postganglionic Sympathetic Fiber|Sympathetic Fibers, Postganglionic	Nerve fibers which project from sympathetic ganglia to synapses on target organs. Sympathetic postganglionic fibers use norepinephrine as transmitter, except for those innervating eccrine sweat glands (and possibly some blood vessels) which use acetylcholine. They may also release peptide cotransmitters. (MeSH)
C12651	Purkinje_s_Cell	Neuron	Purkinje's Cell|Cerebellar Purkinje Cell|Purkinje Cell|Purkinje Cells|Purkinje's Corpuscle|Purkinje's Corpuscles	The output neurons of the cerebellar cortex. (MeSH)
C12652	Pyramidal_Cell	Neuron	Pyramidal Cell|Pyramidal Cells	Projection neurons in the cerebral cortex and the hippocampus. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region. (MeSH)
C12654	Oxyphil_Cell	Glandular_Cell	Oxyphil Cell|Askenazy Cells|Oncocyte|Oncocytes|Oxyphil Cells|Oxyphilic Cell	A glandular cell with acidophilic cytoplasm that contains tightly packed mitochondria. Oxyphil cells are found in the thyroid gland (Hurthle cells) and parathyroid gland.
C12655	APUD_Cell	Neural_Crest-Derived_Cell	APUD Cell|APUD Cells	Cells derived from primitive cell types in the neural crest. During ontogeny they migrate to the foregut and specific locations of the neuroendocrine system. Properly located these cells form part of the normal hormone producing tissues of the neuroendocrine system. If misdirected these cells may become hyperplastic, adenomatous, or malignant. (MeSH)
C12656	Pericyte	Connective_and_Soft_Tissue_Cell	Pericyte|Adventitial Cell|Pericapillary Cell|Pericytes|Perivascular Cell|Rouget Cells	Slender, contractile, mesenchymal-like cells found in close association with capillary walls. They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells. (MeSH)
C12657	Phagocytic_Cell	Antigen_Processing_Cell	Phagocytic Cell|Phagocyte|Phagocytes|Phagocytic cell|amebocyte|phagocyte	An immune system cell that can surround and kill microorganisms and remove dead cells. Phagocytes include macrophages.
C12658	Prokaryotic_Cell	Retired_Concepts	Prokaryotic Cell|Prokaryotic Cells
C12659	Protoplast	Specimen	Protoplast|Protoplasts	A bacterial cell deprived of its cell wall, for example by growth in an isotonic medium in the presence of antibiotics that block synthesis of the wall peptidoglycan. Alternatively, a plant cell similarly deprived by enzymic treatment. (On-line Medical Dictionary)
C12660	Reed-Sternberg_Cell	Neoplastic_Large_Lymphocyte	Reed-Sternberg Cell|R-S Cell|Reed-Sternberg cell	A type of cell that appears in people with Hodgkin's disease. The number of these cells increases as the disease advances.
C12661	Spheroplast	Specimen	Spheroplast|Spheroplasts	Cells, usually bacteria or yeast, which have partially lost their cell wall, lost their characteristic shape and become round. (MeSH)
C12662	Stem_Cell	Cell	Stem Cell|Mother Cells|Progenitor Cells|Stem Cells|stem cells	Cells from which other types of cells can develop.
C12663	Tumor_Stem_Cell	Retired_Concepts	Tumor Stem Cell|Colony-Forming Units, Neoplastic|Stem Cells, Neoplastic|Tumor Stem Cells	Colony-forming cells which give rise to neoplasms. (MeSH)
C12664	Abdominal_Cavity	Cavity	Abdominal Cavity|Abdomen|abdomen	(AB-do-men) The area of the body that contains the pancreas, stomach, intestine, liver, gallbladder, and other organs.
C12665	Abducens_Nerve	Cranial_Nerve	Abducens Nerve|Cranial Nerve VI|Nervus Abducens|Sixth Cranial Nerve
C12666	Adrenal_Gland	Endocrine_Gland	Adrenal Gland|ADRGND|Adrenal Glands|Adrenal glands|Adrenals	Suprarenal gland. A flattened, roughly triangular body resting upon the upper end of each kidney; it is one of the ductless glands furnishing internal secretions (epinephrine and norepinephrine from the medulla and steroid hormones from the cortex). SYN glandula suprarenalis, adrenal body, adrenal capsule, adrenal gland, atrabiliary capsule, epinephros, glandula atrabiliaris, paranephros, suprarenal body, suprarenal capsule.
C12667	Anterior_Chamber_of_the_Eye	Chamber_of_the_Eye	Anterior Chamber of the Eye|Anterior Chamber|Anterior Chamber (Eye)|Anterior Chamber of Eye|Chamber, Anterior	The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)
C12668	Anterior_Eye_Segment	Eye_Segment	Anterior Eye Segment	The part of the eye anterior to the lens, including but not limited to the anterior chamber, cornea and related structures.
C12669	Aorta	Blood_Vessel	Aorta|aorta	(a-OR-tuh) The largest artery in the body. It carries oxygen-rich blood away from the heart to vessels that reach the rest of the body.
C12670	Aortic_Valve	Cardiac_Valve	Aortic Valve
C12671	Upper_Extremity	Limb	Upper Extremity|Forelimb|Upper Limb
C12672	Arteriole	Blood_Vessel	Arteriole
C12673	Autonomic_Nervous_System	Peripheral_Nervous_System_Part	Autonomic Nervous System	The part of the nervous system of vertebrates that controls involuntary actions of the smooth muscles and heart and glands.
C12674	Axilla	Body_Region	Axilla|AX|Armpit|Underarm	The hollow under the arm where it is joined to the shoulder.
C12675	Bartholin_s_Gland	Exocrine_Gland	Bartholin's Gland
C12676	Basilar_Artery	Posterior_Circulation_Intracranial_Artery	Basilar Artery|BA
C12677	Intrahepatic_Bile_Duct	Bile_Duct	Intrahepatic Bile Duct|intrahepatic bile ducts	The bile ducts that pass through and drain bile from the liver.
C12678	Biliary_Tract	Organ	Biliary Tract|Bile Tract|Tract, Biliary
C12679	Blood_Vessel	Cardiovascular_System_Part	Blood Vessel|Blood vessel|VESS|Vessel|blood vessel	A tube through which the blood circulates in the body.  Blood vessels include a network of arteries, arterioles, capillaries, venules, and veins.
C12680	Body_Region	Anatomic_Structure_System_or_Substance	Body Region|Anatomic Region	Named areas of the body.
C12681	Brachial_Artery	Artery	Brachial Artery
C12682	Brachial_Plexus	Nerve_Plexus|Spinal_Nerve	Brachial Plexus|brachial plexus	(BRAY-kee-ul PLEKS-us) A network of nerves that sends signals from the spine to the arm and hand.
C12683	Bronchus	Respiratory_System_Part	Bronchus|Bronchi|bronchi|bronchus	(BRONK-eye) The large air passages that lead from the trachea (windpipe) to the lungs.
C12684	Bronchiole	Respiratory_System_Part	Bronchiole|Bronchioles|Bronchiolus|bronchioles	(BRON-kee-olz) The tiny branches of air tubes in the lungs.
C12685	Capillary	Cardiovascular_System_Part	Capillary
C12686	Cardiovascular_System	Organ_System	Cardiovascular System|Body System, Cardiovascular|Cardiovascular Body System|Cardiovascular Organ System|Cardiovascular system (all sites)|Organ System, Cardiovascular|Vascular, Heart|cardiovascular|circulatory system	Relating to the heart and the blood vessels or the circulation.
C12687	Carotid_Artery	Artery	Carotid Artery
C12688	Carpal_Bone	Bone_of_the_Upper_Extremity	Carpal Bone
C12689	Cauda_Equina	Spinal_Nerve_Root	Cauda Equina
C12690	Cavernous_Sinus	Venous_Sinus	Cavernous Sinus
C12691	Cerebral_Artery	Intracranial_Artery	Cerebral Artery|Cerebral Arteries
C12692	Cerebrospinal_Fluid	Body_Fluid_or_Substance	Cerebrospinal Fluid|CSF|cerebrospinal fluid	(seh-REE-broe-SPY-nal) The fluid flowing around the brain and spinal cord. Cerebrospinal fluid is produced in the ventricles in the brain.
C12693	Cervical_Vertebra	Vertebra	Cervical Vertebra|Cervical Vertebrae
C12694	Choroid_Plexus	Brain_Part	Choroid Plexus
C12695	Clavicle	Bone_of_the_Upper_Extremity|Long_Bone	Clavicle|Collar Bone|clavicle	Collar bone.
C12696	Coccyx	Body_Region|Irregular_Bone	Coccyx
C12697	Cochlear_Nerve	Cranial_Nerve	Cochlear Nerve|Cochlear Root of Acoustic Nerve|Cochlear Root of Eighth Cranial Nerve
C12698	Common_Bile_Duct	Extrahepatic_Bile_Duct	Common Bile Duct|Ductus Communis Choledochus|common bile duct	Bile ducts are passageways that carry bile. Two major bile ducts come together into a "trunk"-the common bile duct which empties into the upper part of the small intestine (the part next to the stomach).
C12699	Corneal_Stroma	Eye_Part	Corneal Stroma	The lamellated connective tissue constituting the thickest layer of the cornea between the Bowman and Descemet membranes. (MeSH)
C12700	Cranial_Nerve	Nerve	Cranial Nerve	Any of the 12 paired nerves that originate in the brain stem.
C12701	Dermis	Skin_Tissue	Dermis|Corium|Cutis|dermis	(DER-mis) The lower or inner layer of the two main layers of tissue that make up the skin.
C12702	Diaphragm	Muscle|Organ	Diaphragm|DIAPH|diaphragm	(DYE-a-fram) The thin muscle below the lungs and heart that separates the chest from the abdomen.
C12703	Ectoderm	Embryonic_Tissue	Ectoderm
C12704	Endocrine_Gland	Gland	Endocrine Gland|Endocrine Organs	Ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions.
C12705	Endocrine_System	Organ_System	Endocrine System|Body System, Endocrine/Metabolic|Endocrine system (all sites)|Endocrine/Metabolic Body System|Endocrine/Metabolic Organ System|Hormonal System|Metabolic/Endocrine Body System|Organ System, Endocrine/Metabolic	Collective designation for those tissues capable of secreting hormones.
C12706	Endoderm	Embryonic_Tissue	Endoderm
C12707	Corneal_Endothelium	Endothelium	Corneal Endothelium
C12708	Epidermis	Skin_Tissue	Epidermis|epidermis	(ep-i-DER-mis) The upper or outer layer of the two main layers of tissue that make up the skin.
C12709	Epiglottis	Head_and_Neck_Part	Epiglottis|epiglottis	(ep-ih-GLAH-tis) The flap that covers the trachea during swallowing so that food does not enter the lungs.
C12710	Epithelium	Epithelial_Tissue	Epithelium|epithelium	(EP-ih-THEE-lee-um) A thin layer of tissue that covers organs, glands, and other structures within the body.
C12711	Ethmoid_Bone	Irregular_Bone	Ethmoid Bone
C12712	Exocrine_Gland	Gland	Exocrine Gland	A gland from which secretions reach a free surface of the body by ducts.
C12713	Eyelid	Eye_Appendage	Eyelid|Palpebra
C12714	Facial_Nerve	Cranial_Nerve	Facial Nerve|Seventh Cranial Nerve	The 7th cranial nerve. The facial nerve has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root. Together they provide efferent innervation to the muscles of facial expression and to the lacrimal and salivary glands, and convey afferent information for taste from the anterior two-thirds of the tongue and for touch from the external ear. (MeSH)
C12715	Femoral_Artery	Artery	Femoral Artery
C12716	Femoral_Vein	Deep_Vein	Femoral Vein
C12717	Femur	Bone_of_the_Lower_Extremity|Long_Bone	Femur
C12718	Fibula	Bone_of_the_Lower_Extremity|Long_Bone	Fibula
C12719	Ganglion	Peripheral_Nervous_System_Part	Ganglion|Ganglia|Neural Ganglion	is a macroscopic organ component of one or more nerves, which primarily consists of cell bodies of neurons located outside the central nervous system; together with nerve fibers, it constitutes a nerve or a nerve plexus. Example(s): spinal ganglion, trigeminal ganglion, superior cervical ganglion, celiac ganglion, inferior hypogastric (pelvic) ganglion.
C12720	Autonomic_Ganglion	Ganglion	Autonomic Ganglion|Autonomic Ganglia
C12721	Geniculate_Ganglion	Sensory_Ganglion	Geniculate Ganglion|Facial Nerve Ganglion|Genicular Ganglia|Genicular Ganglion
C12722	Male_Reproductive_System	Reproductive_System	Male Reproductive System|Body System, Reproductive, Male|Genital System, Male|Male Reproductive Body System|Male Reproductive Organ System|Organ System, Male Reproductive|Penis and Other Genital|Reproductive System, Male|male genital	The sex organs of the male.
C12723	Glossopharyngeal_Nerve	Cranial_Nerve	Glossopharyngeal Nerve|Cranial Nerve IX|Nervus Glossopharyngeus|Ninth Cranial Nerve
C12724	Glottis	Head_and_Neck_Part	Glottis|glottis	(GLAH-tis) The middle part of the larynx; the area where the vocal cords are located.
C12725	Gonad	Other_Anatomic_Concept	Gonad|Gonads|gonads	The gamete-producing tissues, ovary or testis. (MeSH)
C12726	Inguinal_Region	Body_Region	Inguinal Region|Groin|groin	The area where the thigh meets the abdomen.
C12727	Heart	Organ	Heart|HRT	A hollow muscular organ which receives the blood from the veins and propels it into the arteries. It is divided by a musculomembranous septum into two halves -- right or venous and left or arterial -- each of which consists of a receiving chamber (atrium) and an ejecting chamber (ventricle).
C12728	Cardiac_Atrium	Heart_Part	Cardiac Atrium|Atria of Heart|Atria, Cardiac|Atrium|Atrium of Heart|Auricle of Heart|Cardiac Atria|Heart Atria|Heart Atrium	The paired upper chambers of the heart.  The left atrium receives oxygenated blood from the pulmonary vein and pumps blood into the left ventricle.  The right atrium receives venous deoxygenated blood from the entire body via the superior and inferior vena cavae and pumps blood into the right ventricle.
C12729	Cardiac_Valve	Heart_Part	Cardiac Valve|Cardiac Valves|Valve
C12730	Cardiac_Ventricle	Heart_Part	Cardiac Ventricle|Cardiac Ventricles|Heart Ventricle|Ventricle|Ventricles, Heart	The lower right and left chambers of the heart. The right pumps venous blood into the lungs and the left pumps oxygenated blood into the systemic arterial circulation. (MeSH)
C12731	Humerus	Bone_of_the_Upper_Extremity|Long_Bone	Humerus
C12732	Hypoglossal_Nerve	Cranial_Nerve	Hypoglossal Nerve|Twelfth Cranial Nerve
C12733	Iliac_Artery	Artery	Iliac Artery
C12734	Iliac_Vein	Deep_Vein	Iliac Vein
C12735	Immune_System	Organ_System	Immune System|allergic/immunologic body system|allergic/immunologic organ system|body system, allergic/immunologic|immune system|immunologic/allergic organ system|organ system, allergic/immunologic	(im-YOON) The complex group of organs and cells that defends the body against infection or disease.
C12736	Intestine	Organ	Intestine|Bowel|Intestines|bowel|intestine	(in-TES-tin) The long, tube-shaped organ in the abdomen that completes the process of digestion. There is both a large intestine and a small intestine.
C12737	Iris	Eye_Part	Iris
C12738	Jugular_Vein	Vein_of_the_Head_or_Neck	Jugular Vein
C12739	Renal_Cortex	Renal_Tissue	Renal Cortex|Cortical Portion of Kidney|Cortical Portion of the Kidney
C12740	Renal_Medulla	Renal_Tissue	Renal Medulla|Medullary Portion of Kidney|Medullary Portion of the Kidney
C12741	Natural_Killer_Cell_Retired	Retired_Concepts	Natural Killer Cell|Killer Cells|Killer Cells, Natural|NK|NK Cell|NK Cells|NK cells|NK-Cell|killer cells|natural killer cells	NK cells. A type of white blood cell that contains granules with enzymes that can kill tumor cells or microbial cells. Also called large granular lymphocytes.
C12742	Lower_Extremity	Limb	Lower Extremity|Hindlimb|Lower Limb
C12743	Crystalline_Lens	Eye_Part	Lens|Crystalline Lens|Lens of Eye|Ocular Lens	A biconvex transparent structure of the eye through which light is focused on the retina.  The lens sits behind the iris and is supported by the zonule, which connects it to the ciliary body.  The lens is an avascular structure.
C12744	Lumbar_Vertebra	Vertebra	Lumbar Vertebra|Lumbar Vertebrae
C12745	Lymph_Node	Organ	Lymph Node|LN|Lymph Gland|Lymph Nodes|Lymph node|Lymph node proper|Reticuloendothelial System, Lymph Node|lymph gland|lymph node	(limf node) A rounded mass of lymphatic tissue that is surrounded by a capsule of connective tissue. Lymph nodes filter lymph (lymphatic fluid), and they store lymphocytes (white blood cells). They are located along lymphatic vessels.
C12746	Lymphatic_System	Hematopoietic_and_Lymphatic_System_Part	Lymphatic System|LYMPTS|Lymphatic system|Lymphatic system (all sites)|Lymphatics|Reticuloendothelial System, Lymphatic System|lymphatic system	(lim-FAT-ik SIS-tem) The tissues and organs that produce, store, and carry white blood cells that fight infections and other diseases. This system includes the bone marrow, spleen, thymus, lymph nodes, and lymphatic vessels (a network of thin tubes that carry lymph and white blood cells).  Lymphatic vessels branch, like blood vessels, into all the tissues of the body.
C12747	Mast_Cell	Hematopoietic_Cell	Mast Cell|Basophilic Histiocyte|Basophils, Tissue|Marrow Mast Cell|Mast Cells|Mastocyte|mast cell	A type of white blood cell.
C12748	Mediastinum	Body_Region	Mediastinum|mediastinum	(mee-dee-a-STYE-num) The area between the lungs. The organs in this area include the heart and its large blood vessels, the trachea, the esophagus, the bronchi, and lymph nodes.
C12749	Membrane	Tissue	Membrane|MEMB|membrane	A thin sheet or layer of pliable tissue, serving as a covering or envelope of a part, as the lining of a cavity, as a partition or septum, or to connect two structures.
C12750	Mesoderm	Embryonic_Tissue	Mesoderm
C12751	Metacarpal_Bone	Bone_of_the_Upper_Extremity|Long_Bone	Metacarpal Bone|Metacarpal|Metacarpal Bones|Os Metacarpale
C12752	Metatarsal_Bone	Bone_of_the_Lower_Extremity|Long_Bone	Metatarsal Bone|Metatarsal Bones
C12753	Mitral_Valve	Cardiac_Valve	Mitral Valve
C12754	Musculoskeletal_System	Organ_System	Musculoskeletal System	all of the muscles, the bones, and the cartilages of the body.
C12755	Nervous_System	Organ_System	Nervous System|Body System, Neurologic|NRVS-SYS|Neurologic Body System|Neurologic Organ System|Organ System, Neurologic	The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses.
C12756	Nose	Organ_of_the_Special_Sense	Nose	A structure of special sense serving as an organ of the sense of smell and as an entrance to the respiratory tract.
C12757	Occipital_Bone	Flat_Bone	Occipital Bone
C12758	Oculomotor_Nerve	Cranial_Nerve	Oculomotor Nerve|Cranial Nerve III|Third Cranial Nerve
C12759	Olfactory_Nerve	Cranial_Nerve	Olfactory Nerve|Cranial Nerve I|First Cranial Nerve
C12760	Optic_Disc	Eye_Part	Optic Disc|Optic Disk|Optic Nerve Head|Optic Papilla	intraocular portion of the optic nerve formed by fibers converging from retina and appearing as a pink to white disk.
C12761	Optic_Nerve	Cranial_Nerve	Optic Nerve|Second Cranial Nerve|optic nerve	The nerve that carries messages from the retina to the brain.
C12762	Oropharynx	Head_and_Neck_Part	Oropharynx|ORPHX|oropharynx	(or-o-FAIR-inks) The middle part of the throat that includes the soft palate, the base of the tongue, and the tonsils.
C12763	Paranasal_Sinus	Sinus	Paranasal Sinus|Accessory Sinuses|Accessory sinus|Nasal And Sinuses|Nasal Sinus|Nasal Sinuses|Nasal and Sinuses|Nasal cavity/Paranasal|Nasal cavity/Paranasal sinuses|Paranasal Sinuses|Sinuses, Nasal|Sinuses, Paranasal
C12764	Parasympathetic_Nervous_System	Autonomic_Nervous_System_Part	Parasympathetic Nervous System
C12765	Parathyroid_Gland	Endocrine_Gland	Parathyroid Gland|Head and Neck, Parathyroid|Parathyroid|parathyroid glands	One of two small paired endocrine glands, superior and inferior, usually found embedded in the connective tissue capsule on the posterior surface of the thyroid gland; these glands secrete parathyroid hormone that regulates the metabolism of calcium and phosphorus. The parenchyma is composed of chief and oxyphilic cells arranged in anastomosing cords.
C12766	Parietal_Bone	Flat_Bone	Parietal Bone
C12767	Pelvis	Cavity	Pelvis|Pelvic Cavity|pelvis	The lower part of the abdomen, located between the hip bones.
C12768	Peripheral_Nerve	Nerve|Peripheral_Nervous_System_Part	Peripheral Nerve|Peripheral Nerves	The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. (MeSH)
C12769	Peritoneal_Cavity	Cavity	Peritoneal Cavity|peritoneal cavity	The lower part of the abdomen that contains the intestines (the last part of the digestive tract), the stomach, and the liver. It is bound by thin membranes.
C12770	Peritoneum	Membrane	Peritoneum|PERNUM|peritoneum	(PAIR-ih-toe-NEE-um) The tissue that lines the abdominal wall and covers most of the organs in the abdomen.
C12771	Peyer_s_Patch	Gut_Associated_Lymphoid_Tissue	Peyer's Patch|Peyer's Patches	Lymphoid tissue on the mucosa of the small intestine. (MeSH)
C12772	Anterior_Lobe_of_the_Pituitary_Gland	Endocrine_System_Part	Anterior Lobe of the Pituitary Gland|Adenohypophysis|Anterior Lobe of Pituitary|Anterior Lobe of Pituitary Gland|Anterior Pituitary Gland|Gland, Anterior Pituitary|Glands, Anterior Pituitary|Pars Anterior Pituitary Gland|Pituitary Anterior Lobe|Pituitary Gland, Anterior	The glandular or anterior lobe of the pituitary gland which secretes several hormones.
C12773	Posterior_Lobe_of_the_Pituitary_Gland	Endocrine_System_Part	Posterior Lobe of the Pituitary Gland|Neurohypophysis|Posterior Lobe of Pituitary|Posterior Lobe of Pituitary Gland|Posterior Pituitary Gland	The neural or post-neural lobe of the pituitary gland which stores and releases vasopressin, oxytocin, and neurophysins.
C12774	Pulmonary_Artery	Artery	Pulmonary Artery	large artery originating from the superior surface of right ventricle and carrying deoxygenated blood from heart to lung.
C12775	Pulmonary_Valve	Cardiac_Valve	Pulmonary Valve|Pulmonic Valve
C12776	Pulmonary_Vein	Vein	Pulmonary Vein	large vein carrying oxygenated blood from lungs to left atrium.
C12777	Radius_Bone	Bone_of_the_Upper_Extremity|Long_Bone	Radius Bone|Radial Bone|Radius
C12778	Renal_Artery	Abdominal_Aorta_Branch	Renal Artery
C12779	Respiratory_System	Organ_System	Respiratory System|Body System, Pulmonary|Organ System, Pulmonary|Pulmonary Body System|Pulmonary Organ System|Respiratory system (all sites)|respiratory system|respiratory tract	(RES-pih-ra-tor-ee) The organs that are involved in breathing. These include the nose, throat, larynx, trachea, bronchi, and lungs.Also known as the respiratory tract.
C12780	Reticuloendothelial_System	Other_Anatomic_Concept	Reticuloendothelial System|RE System	A widely distributed collection of both free and fixed macrophages derived from bone marrow precursor cells by way of monocytes; their substantial phagocytic activity is mediated by immunoglobulin and the serum complement system. In both connective and lymphoid tissue, they may occur as free and fixed macrophages; in the sinusoids of the liver, as Kupffer cells; in the lung, as alveolar macrophages; and in the nervous system, as microglia.
C12781	Retroperitoneal_Space	Retired_Concepts	Retroperitoneal Space|Retroperitoneal Cavity
C12782	Rib	Flat_Bone	Rib
C12783	Scapula	Bone_of_the_Upper_Extremity|Flat_Bone	Scapula|Shoulder Blade
C12784	Sclera	Eye_Part	Sclera|White of Eye	The white, opaque, fibrous, outer tunic of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea. It is essentially avascular but contains apertures for vessels, lymphatics, and nerves. It receives the tendons of insertion of the extraocular muscles and at the corneoscleral junction contains the canal of Schlemm. (From Cline et al., Dictionary of Visual Science, 4th ed)
C12785	Scrotum	Skin	Scrotum|scrotum	(SKRO-tum) In males, the external sac that contains the testicles.
C12786	Lunate_Bone	Carpal_Bone	Lunate Bone|Lunate|Semilunar Bone
C12787	Seminal_Vesicle	Organ	Seminal Vesicle|Seminal Sacs|Seminal Vesicles|seminal vesicles	(SEM-in-al VES-ih-kulz) Glands that help produce semen.
C12788	Skeletal_System	Musculoskeletal_System_Part	Skeletal System|Skeleton|skeletal|skeleton	Having to do with the skeleton (boney part of the body).
C12789	Skull	Bone	Skull|Cranium
C12790	Sphenoid_Bone	Irregular_Bone	Sphenoid Bone
C12791	Spinal_Nerve_Root	Central_Nervous_System_Part	Spinal Nerve Root|Spinal Nerve Roots|Spinal Roots
C12792	Spinal_Nerve	Nerve	Spinal Nerve|Spinal Nerves
C12793	Sternum	Flat_Bone	Sternum
C12794	Subclavian_Vein	Deep_Vein	Subclavian Vein
C12795	Sympathetic_Nervous_System	Autonomic_Nervous_System_Part	Sympathetic Nervous System|SNS
C12796	Tarsal_Bone	Bone_of_the_Lower_Extremity	Tarsal Bone|Tarsal Bones
C12797	Temporal_Bone	Irregular_Bone	Temporal Bone
C12798	Thoracic_Vertebra	Vertebra	Thoracic Vertebra|Thoracic Vertebrae
C12799	Thorax	Body_Region	Thorax
C12800	Tibia	Bone_of_the_Lower_Extremity|Long_Bone	Tibia
C12801	Tissue	Microanatomy	Tissue|Normal Tissue|TISS|Tissue Types|Tissues|tissue	(TISH-oo) A group or layer of cells that are alike and that work together to perform a specific function.
C12802	Tonsil	Organ	Tonsil|Tonsils|tonsils	Small masses of lymphoid tissue on either side of the throat.
C12803	Trabecular_Meshwork	Other_Anatomic_Concept	Trabecular Meshwork	A porelike structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates to the canal of Schlemm. (MeSH)
C12804	Transplanted_Bone_Marrow	Retired_Concepts	Transplanted Bone Marrow
C12805	Tricuspid_Valve	Cardiac_Valve	Tricuspid Valve
C12806	Trigeminal_Nerve	Cranial_Nerve	Trigeminal Nerve|Cranial Nerve V|Fifth Cranial Nerve|Nervus Trigeminus
C12807	Trigeminal_Nucleus	Other_Anatomic_Concept	Trigeminal Nucleus|Nucleus of Fifth Nerve|Nucleus of the Fifth Nerve|Trigeminal Nuclei
C12808	Trochlear_Nerve	Cranial_Nerve	Trochlear Nerve|Cranial Nerve IV|Fourth Cranial Nerve
C12809	Ulna	Bone_of_the_Upper_Extremity|Long_Bone	Ulna	One of the bones that comprise the forearm. The largest aspect articulates with the humerus at the elbow joint and the smallest portion of the ulna articulates with the carpal bones in the wrist. (On-line Medical Dictionary)
C12810	Genitourinary_System	Other_Anatomic_Concept	Genitourinary System|Urogenital System|genitourinary|genitourinary system	(GEN-ih-toe-YOO-rin-air-ee) The parts of the body that play a role in reproduction, getting rid of waste products in the form of urine, or both.
C12811	Uvea	Eye_Part	Uvea|Iris, Ciliary Body and Choroid|Tunica Vasculosa of Eyeball|Uveal Tract
C12812	Vagus_Nerve	Cranial_Nerve	Vagus Nerve|Cranial Nerve X|Pneumogastric Nerve|Tenth Cranial Nerve
C12813	Vas_Deferens	Organ	Vas Deferens|vas deferens	A coiled tube that carries the sperm out of the testes.
C12814	Vein	Blood_Vessel	Vein	is a blood vessel of macroscopic dimensions, the lumen of which is continuous with the atria of the heart, directly or indirectly through tributaries of the venae cavae, pulmonary veins and the hepatic and portal veins. Example(s): coronary sinus, posterior intercostal vein, renal vein, basal vein of right lung, inferior mesenteric vein.
C12815	Inferior_Vena_Cava	Deep_Vein	Inferior Vena Cava|inferior vena cava	A large vein that empties into the heart. It carries blood from the legs and feet and from organs in the abdomen and pelvis.
C12816	Superior_Vena_Cava	Deep_Vein	Superior Vena Cava|superior vena cava	The large vein that carries blood from the head, neck, arms, and chest to the heart.
C12817	Vena_Cava	Vein	Vena Cava
C12818	Venule	Blood_Vessel	Venule
C12819	Vertebral_Artery	Posterior_Circulation_Intracranial_Artery	Vertebral Artery|VA
C12820	Vestibular_Nerve	Cranial_Nerve	Vestibular Nerve|Vestibular Nerve (VIII)|Vestibular Root of Eighth Cranial Nerve
C12821	Vestibular_Nucleus	Brain_Part	Vestibular Nucleus|Vestibular Nuclei
C12822	Vocal_Cord	Head_and_Neck_Part	Vocal Cord|Vocal Cords	Two small bands of muscle within the larynx. They close to prevent food from getting into the lungs, and they vibrate to produce the voice.
C12823	Corneoscleral_Limbus	Eye_Part	Corneoscleral Limbus|Corneal Limbus
C12824	Tibial_Artery	Artery	Tibial Artery|Tibial Arteries
C12825	Anterior_Tibial_Artery	Artery	Anterior Tibial Artery
C12826	Posterior_Tibial_Artery	Artery	Posterior Tibial Artery
C12827	Third_Ventricle_of_Brain	Ventricle_Brain	Third Ventricle|Third Cerebral Ventricle|Third Ventricle of Brain|Ventricle, Third	A centrally placed component of the ventricular system of the brain located in the diencephalon. Cerebrospinal fluid from the lateral ventricles flows into the third ventricle via the foramina of Monroe and exits the third ventricle via the aqueduct of Sylvius. The thalamus and hypothalamus border the lateral walls of the third ventricle.
C12828	Fourth_Ventricle_of_the_Brain	Ventricle_Brain	Fourth Ventricle|Fourth Ventricle of Brain|Fourth Ventricle of the Brain
C12829	Anterior_Cerebral_Artery	Internal_Carotid_Artery_Branch	Anterior Cerebral Artery|ACA|Anterior Cerebral Arteries
C12830	Middle_Cerebral_Artery	Internal_Carotid_Artery_Branch	Middle Cerebral Artery|MCA|Middle Cerebral Arteries
C12831	Posterior_Cerebral_Artery	Basilar_Artery_Branch	Posterior Cerebral Artery|PCA|Posterior Cerebral Arteries	The posterior cerebral artery is formed by the bifurcation of the basilar artery; it divides into three branches.
C12832	Conus_Medullaris	Spinal_Cord_Part	Conus Medullaris
C12833	Anterior_Spinal_Artery	Spinal_Artery	Anterior Spinal Artery
C12834	Lateral_Ventricle	Ventricle_Brain	Lateral Ventricle|Lateral Ventricle of Brain|Lateral Ventricles|Ventricle, Lateral|Ventricles, Lateral	The rostral extensions of the ventricular system of the brain consisting of two cavities, one on each side of the brain within the central regions of each cerebral hemisphere.  Cerebrospinal fluid flows from the lateral ventricles into the centrally third ventricle via the foramen of Monroe.
C12835	Nucleus_Ambiguus	Brain_Part	Nucleus Ambiguus
C12836	Abducens_Nucleus	Brain_Part	Abducens Nucleus|Sixth Cranial Nerve Nucleus
C12837	Cochlear_Nuclei	Other_Anatomic_Concept	Cochlear Nuclei
C12838	Radial_Artery	Artery	Radial Artery
C12839	Ulnar_Artery	Artery	Ulnar Artery
C12840	Pleural_Cavity	Cavity	Pleural Cavity|pleural cavity	A space enclosed by the pleura (thin tissue covering the lungs and lining the interior wall of the chest cavity). The pleural cavity is bound by thin membranes.
C12841	Reproductive_System	Organ_System	Reproductive System|reproductive system	In women, this system includes the ovaries, the fallopian tubes, the uterus (womb), the cervix, and the vagina (birth canal). The reproductive system in men includes the prostate, the testes, and the penis.
C12842	Skin_Graft	Graft	Skin Graft|skin graft	Grafts used in the treatment of skin loss, usually caused by burn injuries.
C12843	Coronary_Artery	Ascending_Aorta_Branch	Coronary Artery
C12844	Cervical	Anatomy_Modifier	Cervical|cervical	Relating to a neck, or cervix, in any sense.
C12845	Lumbar_Plexus	Nerve_Plexus	Lumbar Plexus
C12846	Sacral_Plexus	Nerve_Plexus	Sacral Plexus
C12847	Reactive_Lymphocyte	Abnormal_Lymphocyte	Reactive Lymphocyte
C12848	Squamous_Epithelium	Epithelium	Squamous Epithelium	A simple or stratified flat epithelium.
C12849	Squamous_Cell	Epithelial_Cell	Squamous Cell|Squamous Cells|squamous cells	(SKWAY-mus) Flat cells that look like fish scales under a microscope. These cells cover internal and external surfaces of the body.
C12850	Stratum_Spinosum	Skin_Part	Stratum Spinosum|Spiny Layer	The part of the epidermis layer of the skin containing Langerhans cells, which are dendritic, MHC class II-expressing antigen presenting cells.
C12851	Female_Breast	Breast	Female Breast|Breast, Female	The organ of milk secretion; one of two hemispheric projections of variable size situated in the subcutaneous layer over the pectoralis major muscle on either side of the chest of the mature female; it is rudimentary in the male.
C12852	Vertebral_Body	Musculoskeletal_System_Part	Vertebral Body|Body of Vertebra|Body of the Vertebra
C12853	Sacral_Vertebra	Vertebra	Sacral Vertebra|Sacral Vertebrae
C12854	Scaphoid_Bone	Carpal_Bone	Scaphoid Bone|Navicular Bone of Hand|Os Scaphoideum|Scaphoid
C12855	Pisiform_Bone	Carpal_Bone	Pisiform Bone|Pisiform|Pisiform Bone of Hand
C12856	Capitate_Bone	Carpal_Bone	Capitate Bone|Capitate
C12857	Trapezial_Bone	Carpal_Bone	Trapezial Bone|Greater Multiangular Bone|Trapezium	A bone of the carpus at the base of the first metacarpal, or thumb. (On-line Medical Dictionary)
C12858	Triangular_Bone	Carpal_Bone	Triangular Bone
C12859	Trapezoid_Bone	Carpal_Bone	Trapezoid Bone|Lesser Multiangular Bone|Trapezoid	A bone in the distal row of the carpus; it articulates with the second metacarpal, trapezium, capitate, and scaphoid. (On-line Medical Dictionary)
C12860	Hamate_Bone	Carpal_Bone	Hamate Bone|Hamate|Unciform Bone|Uncinate Bone
C12861	Phalanx_of_the_Hand	Bone_of_the_Upper_Extremity	Phalanx of the Hand|Bone of Finger|Phalanges of Hand|Phalanx of Finger|Phalanx of Hand
C12862	Proximal_Phalanx_of_the_Hand	Phalanx_of_the_Hand	Proximal Phalanx of the Hand|Proximal Phalanx of Finger|Proximal Phalanx of Hand
C12863	Middle_Phalanx_of_the_Hand	Phalanx_of_the_Hand	Middle Phalanx of the Hand|Middle Phalanx of Finger|Middle Phalanx of Hand
C12864	Distal_Phalanx_of_the_Hand	Phalanx_of_the_Hand	Distal Phalanx of the Hand|Distal Phalanx of Finger|Distal Phalanx of Hand
C12865	Endothelial_Cell	Connective_and_Soft_Tissue_Cell	Endothelial Cell|Endothelial Cells|endothelial cell	The main type of cell forming the lining of blood and lymph vessels and the inner layer of the endocardium. SYN endotheliocyte.
C12866	Transitional_Cell	Epithelial_Cell	Transitional Cell|Transitional Cells|transitional cells	Cells that vary in shape depending on whether the tissue is being stretched.  The cells may be stretched without breaking apart.  They line hollow organs such as the bladder.
C12867	Alveolar_Epithelium	Epithelium	Alveolar Epithelium|Lung Alveolar Epithelia	Epithelia of lung alveoli. The layer of cells covering the lining of the tiny air sacs at the end of the bronchioles.
C12868	Right_Atrium	Cardiac_Atrium	Right Atrium
C12869	Left_Atrium	Cardiac_Atrium	Left Atrium|Left Atrium of Heart
C12870	Right_Ventricle	Cardiac_Ventricle	Right Ventricle
C12871	Left_Ventricle	Cardiac_Ventricle	Left Ventricle
C12872	Left_Coronary_Artery	Coronary_Artery	Left Coronary Artery
C12873	Diagonal_Branch_of_Descending_Branch_of_Left_Coronary_Artery	Retired_Concepts	Diagonal Branch of Descending Branch of Left Coronary Artery
C12874	Circumflex_Branch_of_the_Left_Coronary_Artery	Left_Coronary_Artery_Branch	Circumflex Branch of the Left Coronary Artery|Circumflex Branch of Left Coronary Artery
C12875	Right_Coronary_Artery	Coronary_Artery	Right Coronary Artery|RIght Coronary Artery
C12876	Posterior_Spinal_Artery	Spinal_Artery|Vertebral_Artery_Branch	Posterior Spinal Artery
C12877	Venous_Sinus	Other_Anatomic_Concept	Venous Sinus
C12878	Cardiac_Vein	Deep_Vein	Cardiac Vein
C12879	Great_Cardiac_Vein	Cardiac_Vein	Great Cardiac Vein
C12880	Middle_Cardiac_Vein	Cardiac_Vein	Middle Cardiac Vein
C12881	Small_Cardiac_Vein	Cardiac_Vein	Small Cardiac Vein
C12882	Coronary_Vein	Cardiac_Vein	Coronary Vein
C12883	Brachial_Vein	Deep_Vein	Brachial Vein
C12884	Urothelium	Transitional_Epithelium	Urothelium|urothelium	The lining of the ureters, bladder, and urethra.
C12885	Renal_Capsule	Kidney_Part|Organ_Capsule	Renal Capsule|renal capsule	The fibrous connective tissue that surrounds each kidney.
C12886	Renal_Pyramid	Renal_Tissue	Renal Pyramid	A cone-shaped structure of the kidney. It is located in the medullary portion of the kidney (pyramid of Malpighi) or the cortical portion of the kidney (pyramid of Ferrein).
C12887	Renal_Pelvis	Kidney_Part	Renal Pelvis|renal pelvis	The area at the center of the kidney. Urine collects here and is funneled into the ureter, the tube that connects the kidney to the bladder.
C12888	Visual_System	Special_Sense_Organ_System	Visual System|Visual Pathway
C12889	Auditory_System	Special_Sense_Organ_System	Auditory System	The organs involved with detecting and processing auditory information, including the pinna, external auditory canal, ear drum, middle ear, and inner ear (including the cochlear organ).
C12890	Falx_Cerebri	Central_Nervous_System_Part	Falx Cerebri|Cerebral Falx|Falx of Cerebrum
C12891	Central_Canal	Spinal_Cord_Part	Central Canal of Spinal Cord|Central Canal
C12892	Cervical_Spinal_Cord	Spinal_Cord_Part	Cervical Spinal Cord|Cervical Portion of Spinal Cord
C12893	Cervical_Spinal_Nerve_Root	Spinal_Nerve_Root	Cervical Spinal Nerve Root|Cervical Spinal Nerve Roots
C12894	Thoracic_Spinal_Cord	Spinal_Cord_Part	Thoracic Spinal Cord|Thoracic Portion of Spinal Cord
C12895	Lumbar_Spinal_Cord	Spinal_Cord_Part	Lumbar Spinal Cord|Lumbar Portion of Spinal Cord
C12896	Sacral_Spinal_Cord	Spinal_Cord_Part	Sacral Spinal Cord
C12897	Oculomotor_Nucleus	Brain_Part	Oculomotor Nucleus
C12898	Facial_Nerve_Nucleus	Brain_Part	Facial Nerve Nucleus|Facial Nucleus
C12899	Hypoglossal_Nucleus	Brain_Part	Nucleus of the Hypoglossal Nerve|Hypoglossal Nucleus
C12900	Posterior_Chamber_of_the_Eye	Chamber_of_the_Eye	Posterior Chamber of the Eye|Posterior Chamber (Eye)|Posterior Chamber of Eye
C12901	Palpebral_Conjunctiva	Conjunctiva	Palpebral Conjunctiva	The part of the conjunctiva, a thin transparent mucous membrane, that covers the posterior surface of the eyelids.
C12902	Bulbar_Conjunctiva	Conjunctiva	Bulbar Conjunctiva|Ocular Conjunctiva	The part of the conjunctiva, a thin transparent mucous membrane, that is loosely attached the orbital septum and covers the anterior surface of the sclera.
C12903	Supraclavicular_Lymph_Node	Lymph_Node_by_Anatomic_Site	Supraclavicular Lymph Node|Supraclavicular Lymph Nodes|supraclavicular lymph nodes	Lymph nodes located above the clavicle (collarbone).
C12904	Axillary_Lymph_Node	Lymph_Node_by_Anatomic_Site	Axillary Lymph Node|AXN|Axillary Lymph Nodes|Axillary Node|axillary lymph nodes	A lymph node located in the armpit.  It drains the lymphatic vessels that originate from the breast tissue.
C12905	Thoracic_Cavity	Cavity	Thoracic Cavity	The cavity in the vertebrate body enclosed by the ribs between the diaphragm and the neck and containing the lungs and heart.
C12906	Posterior_Eye_Segment	Eye_Segment	Posterior Eye Segment
C12907	Integumentary_System	Organ_System	Integumentary System|Body System, Dermatologic|Dermatologic Body System|Dermatologic Organ System|Organ System, Dermatologic
C12908	Other_Unique_Body_System	Other_Anatomic_Concept	Other/Unique Body System|Other/unique Body System|body system, other/unique|organ system, other/unique|other/unique organ system|unique/other body system
C12909	Hematopoietic_System	Hematopoietic_and_Lymphatic_System_Part	Hematopoietic System|Body System, Hematologic|Hematologic Body System|Hematologic Organ System|Hematopoietic Body System|Hematopoietic system|Organ System, Hematologic
C12910	Mucosa-Associated_Lymphoid_Tissue	Lymphoid_Tissue	Mucosa-Associated Lymphoid Tissue|Lymphoid Tissue, Mucosa-associated|MALT	Lymphoid tissue located beneath the mucosal epithelia of those mucosal surfaces that have contact with the external environment, such as the respiratory, digestive, and urinary systems. MALT consists of a collection of predominantly small lymphocytes, fewer larger, transformed lymphocytes, and plasma cells. It protects the body from pathogens that enter via the mucosa. MALT gives rise to a distinctive type of B-cell lymphoma that usually follows an indolent clinical course.
C12911	Spinal_Accessory_Nerve	Other_Anatomic_Concept	Spinal Accessory Nerve
C12912	Caco-2_Cell	Adenocarcinoma_Cell	Caco-2 Cell
C12913	Abnormal_Cell	root_node	Abnormal Cell
C12914	Atypical_Lymphoblast	Leukemic_Lymphocyte|Neoplastic_Blast	Neoplastic Lymphoblast|Atypical Lymphoblast
C12915	Small_Cleaved_Cell	Activated_B-Lymphocyte	Small Cleaved Follicle Center Cell|Small Cleaved Cell	A lymphoid cell of follicular center cell origin that has an irregularly shaped nucleus with clumped chromatin, absent nucleoli, and one or more clefts in the nuclear membrane.
C12916	Micromegakaryocyte	Dysplastic_Megakaryocyte	Micromegakaryocyte|Atypically Small Megakaryocyte
C12917	Malignant_Cell	Neoplastic_Cell	Malignant Cell|Cancer Cell	Cells of, or derived from, a malignant tumor.
C12918	Blast_Cell	Hematopoietic_Cell	Blast Cell|Blast Cells|Blasts|blasts	Blast cells are in an immature (undifferentiated) stage in cellular development, occurring before the appearance of the definitive characteristics exhibited by fully differentiated cells.
C12919	Organ_System	Anatomic_Structure_System_or_Substance	Organ System|Body Systems	An anatomical structure that consists of organs and organ subclasses responsible for certain body functions.  Representative examples are the gastrointestinal system, urinary system, and hematopoietic system.
C12920	EBV-Specific_Cytotoxic_T-Lymphocyte	Cytotoxic_T-Lymphocyte	EBV-Specific Cytotoxic T-Lymphocyte|EBV-specific CTL|EBV-specific Cytotoxic T-lymphocyte|EBV-specific Cytotoxic T-lymphocytes|Epstein-Barr virus-specific cytotoxic T-lymphocytes	A white blood cell that is derived from a lymphocyte stem cell matured in the thymus and characterized by a CD8 marker on the surface and an antigen-specific Epstein Barr virus T cell receptor.
C12921	Large_Granular_Lymphocyte	Lymphocyte	Large Granular Lymphocyte|LGL|Large Granular Lymphocytes|large granular lymphocytes	A type of white blood cell that contains granules with enzymes that can kill tumor cells or microbial cells. Also called natural killer cells.
C12922	Neoplastic_Cell	Abnormal_Cell	Neoplastic Cell|Tumor Cell	Cells of, or derived from, a tumor.
C12923	Supratentorial	Anatomy_Modifier	Supratentorial|supratentorial	Located in the upper part of the brain.
C12924	Lumbar_Spinal_Nerve_Root	Spinal_Nerve_Root	Lumbar Spinal Nerve Root|Lumbar Spinal Nerve Roots
C12925	Sacral_Spinal_Nerve_Root	Spinal_Nerve_Root	Sacral Spinal Nerve Root|Sacral Spinal Nerve Roots
C12926	Thoracic_Spinal_Nerve_Root	Spinal_Nerve_Root	Thoracic Spinal Nerve Root|Thoracic Spinal Nerve Roots
C12927	Renal_Calyx	Kidney_Part	Renal Calyx|Renal Calix|Renal Calyces
C12928	Corneal_Epithelium	Stratified_Epithelium	Corneal Epithelium	Stratified squamous epithelium that covers the outer surface of the cornea. (MeSH)
C12929	Nerve_Plexus	Nerve|Peripheral_Nervous_System_Part	Nerve Plexus|Nerve Plexi	is a subdivision of the peripheral nervous system (organ system subdivision), which consists of subdivisions of two or more nerves, which are interconnected with one another to form an network through which nerve fibers of the constituent nerves of the plexus become regrouped; together with other nerve plexuses and nerves, it constitutes the peripheral nervous system. Example(s): brachial plexus, cardiac plexus, inferior hypogastric plexus.
C12930	Intrapulmonary_Bronchus	Bronchus	Intrapulmonary Bronchus
C12931	Meningeal	Anatomy_Modifier	Meningeal|meningeal	Refers to the meninges, the tissue covering the brain and spinal cord.
C12932	Xenograft	Graft	Xenograft|xenograft	A graft transferred from an animal of one species to one of another species.
C12933	Vertebra	Bone	Vertebra|Vertebrae
C12934	Dorsal_Motor_Nucleus	Brain_Part	Dorsal Motor Nucleus|DMN|Dorsal Motor Nucleus of the Vagus
C12935	Embryonic_Stem_Cell	Embryonic_Cell|Pluripotent_Stem_Cell	Embryonic Stem Cell|Embryonic Stem Cells	Embryonic stem (ES) cells are cells derived from the inner cell mass of the early embryo that can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent.
C12936	Gut_Associated_Lymphoid_Tissue	Mucosa-Associated_Lymphoid_Tissue	Gut-Associated Lymphoid Tissue|GALT|GUT-Associated Lymphoid Tissue|Gut Associated Lymphoid Tissue	Non-encapsulated accumulations of lymphoid tissue in the alimentary tract that form a secretory immune system containing cells committed to IgA or IgE synthesis; It includes Peyer's patches and the lymphoid tissue which is present throughout the gastrointestinal mucosa. (partially adapted from CSP98)
C12937	Mammary_Epithelium	Epithelium|Mammary_Gland_Tissue	Mammary Epithelium	The epithelium that lines the lactiferous ducts and the secretory alveoli. The mammary epithelium in the lactiferous duct is a two layered epithelium. The basal cells are cuboidal and the superficial cells are columnar. Branches of the lactiferous duct are lined with a simple cuboidal epithelium. The secretory alveoli are lined by a cuboidal or columnar epithelium. During the first half of pregnancy, the epithelium undergoes considerable growth leading to the formation of new terminal branches of ducts and of alveoli. The mammary glands continue to grow during the second half of pregnancy due to increases in the height of epithelial cells and an expansion of the lumen of the alveoli.
C12938	Peripheral_Blood_Lymphocyte	Leukocyte|Mature_Lymphocyte	Peripheral Blood Lymphocyte|PBL
C12939	Autologous_Lymphocyte	Lymphocyte	Autologous Lymphocyte|Autologous Lymphocytes|autologous lymphocytes	A person's white blood cells. Lymphocytes have a number of roles in the immune system, including the production of antibodies and other substances that fight infection and disease.
C12940	Autologous_Tumor_Cell	Neoplastic_Cell	Autologous Tumor Cell|Autologous Tumor Cells
C12941	Coactivated_T-Cell	Biological_Agent	Coactivated T Cell|Coactivated T Cells|coactivated T cells	T cells that have been coated with monoclonal antibodies to enhance their ability to kill tumor cells.
C12942	Intracarotid	Anatomy_Modifier	Intracarotid
C12943	Intrathecal_Space	Other_Anatomic_Concept	Intrathecal Space|Intrathecal|intrathecal	(in-tra-THEE-kal) Describes the fluid-filled space between the thin layers of tissue that cover the brain and spinal cord.  Drugs can be injected into the fluid or a sample of the fluid can be removed for testing.
C12944	Medial_Supraclavicular_Lymph_Node	Supraclavicular_Lymph_Node	Medial Supraclavicular Lymph Node|Medial Supraclavicular Lymph Nodes|medial supraclavicular lymph nodes	Lymph nodes located above the collar bone and between the center of the body and a line drawn through the nipple to the shoulder.
C12945	Neuroendocrine_System	Other_Anatomic_Concept	Neuroendocrine System|Neuroendocrine|Neurosecretory System|neuroendocrine	(NOO-ro-EN-do-krin) Having to do with the interactions between the nervous system and the endocrine system.  Neuroendocrine describes certain cells that release hormones into the blood in response to stimulation of the nervous system.
C12946	Peripheral_Blood_Stem_Cell	Hematopoietic_Stem_Cell|Peripheral_Blood_Cell	Peripheral Blood Stem Cell|PBSC|Peripheral Blood Stem Cells|Peripheral Stem Cells|peripheral stem cells	An immature (progenitor) cell circulating in the peripheral blood.  It has the capacity for replication and differentiation to mature blood cells.
C12947	Sentinel_Lymph_Node	Lymph_Node	Sentinel Lymph Node|SN|Sentinel Node|sentinel lymph node	The first lymph node that is affected by cancer spread from the primary site.  Sentinel lymph node biopsy is part of the staging work-up to determine early metastasis to regional lymph nodes in patients with breast carcinoma or melanoma.
C12948	Duct	Organ	Duct|duct	(dukt) A tube through which body fluids pass.
C12949	Somatic_Cell	Eukaryotic_Cell	Somatic Cell|Somatic Cells|somatic cells	All the body cells except the reproductive (germ) cells.
C12950	Embryonic_Tissue	Embryonic_Structure	Embryonic Tissue
C12951	Splenocyte	Other_Anatomic_Concept	Splenocyte|Splenocytes	A vague term that usually refers to the phagocytic cells (macrophages) of the spleen. (from On-line Medical Dictionary)
C12952	Upper_Aerodigestive_Passage	Retired_Concepts	Upper Aerodigestive Passage|Upper Aerodigestive
C12953	Nervous_System_Fluids_and_Secretions	Other_Anatomic_Concept	Nervous System Fluids and Secretions|Nervous System Fluids, Secretion|Nervous System, Fluids, Secretions|Nervous System-Fluids, Secretions	Fluids and secretions related to the nervous system. The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses.
C12954	Peripheral_Blood_Mononuclear_Cell	Leukocyte	Peripheral Blood Mononuclear Cell|PBMC
C12955	Nervous_System_Ear	Other_Anatomic_Concept	Nervous System, Ear
C12956	Neuro-Ocular_System	Other_Anatomic_Concept	Neuro-Ocular System|Nervous System, Eye	The components of the eye that are also part of the nervous system, including the retina and optic nerve.
C12957	Exocrine_System	Organ_System	Exocrine System	All endocrine glands, considered as a coherent system.
C12958	Mammalian_Cell	Cell	Mammalian Cell	A cell originating from or isolated from an animal of class Mammalia.
C12959	Human_Breast_Cancer_Cell	Malignant_Epithelial_Cell	Breast Cancer Cell|Human Breast Cancer Cell|Human Breast Cancer Cells	Cells found in human breast cancers or extracted from cancers as established cell lines
C12960	Liver_Stem_Cell	Stem_Cell	Liver Stem Cell|Liver Stem Cells	An undifferentiated cell found in the liver.
C12961	Trachea_and_Bronchus	Other_Anatomic_Concept	Trachea and Bronchus|Respiratory System, Trachea, Bronchus|Trachea, Bronchus	Trachea -The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi. Bronchi-The larger air passages of the lungs arising from the terminal bifurcation of the trachea.
C12962	Clonogen	Retired_Concepts	Clonogen	A tumor progenitor cell.
C12963	Gut_Epithelium	Epithelium	Gut Epithelium	The epithelium that lines the intestinal tract.
C12964	Connective_and_Soft_Tissue	Tissue	Connective and Soft Tissue|Connective And Soft Tissue
C12965	Genital_System_Female_Other	Retired_Concepts	Genital System Female Other|Other Genital Female
C12966	Genital_System_Male_Other	Retired_Concepts	Genital System Male Other
C12967	Ascending_Spinal_Cord_Tract	Spinal_Cord_Tract	Ascending Spinal Cord Tract|Ascending Spinal Cord Tracts|Ascending Spinal Tracts|Ascending Tracts of Spinal Cord
C12968	Tumor-Associated_Vasculature	Other_Anatomic_Concept	Tumor-Associated Vasculature|Neovasculature	New blood vessels formed by solid tumors.
C12969	Descending_Spinal_Cord_Tract	Spinal_Cord_Tract	Descending Spinal Cord Tract|Descending Spinal Cord Tracts|Descending Spinal Tracts
C12970	Pontine_Base	Brain_Part	Pontine Base|Base of Pons|Basis Pontis
C12971	Breast	Organ	Breast|BRST|Breasts	One of two hemispheric projections of variable size situated in the subcutaneous layer over the pectoralis major muscle on either side of the chest.
C12972	Peripheral_Nerve_Sheath	Nerve_Sheaths	Peripheral Nerve Sheath	The protective covering surrounding the axon of neurons in the peripheral nervous system.
C12973	Cervicomedullary_Junction	Spinal_Cord_Part	Cervicomedullary Junction|Cervico-medullary Junction
C12974	Supratentorial_Nervous_System	Retired_Concepts	Supratentorial Nervous System|Supratentorial Anatomy
C12975	Infratentorial_Nervous_System	Retired_Concepts	Infratentorial Nervous System|Infratentorial Anatomy
C12976	Premalignant_Cell	Neoplastic_Cell	Premalignant Cell|Precancerous Cells	A term used to describe a condition that may (or is likely to) become cancer. Also called precancerous.
C12977	Pluripotent_Stem_Cell	Stem_Cell	Pluripotent Stem Cell|pluripotent stem cells	A cell that can differentiate to cells derived from any of the three germ layers. --2005
C12978	Totipotent_Stem_Cell	Stem_Cell	Totipotent Stem Cell	Totipotent stem cells, such as the product of fertilization of an ovum and its progeny, are stem cells that have total potency to form an entire mature organism, e.g., a human being, although only if placed in a woman's uterus.
C12979	Atypical_Mononuclear_Cell	Abnormal_Cell	Atypical Mononuclear Cell
C12980	Intracranial_Artery	Artery	Intracranial Artery|Intracranial Arteries	Arteries which have their origins within the intracranial cavity.
C12981	Graft	Other_Anatomic_Concept	Graft|TSPL|Transplant|graft	Healthy skin, bone, or other tissue taken from one part of the body and used to replace diseased or injured tissue removed from another part of the body.
C12982	Bone_of_the_Lower_Extremity	Bone_of_the_Extremity	Bone of the Lower Extremity|Bone of Lower Extremity|Bones of Lower Extremity
C12983	Bone_of_the_Upper_Extremity	Bone_of_the_Extremity	Bone of the Upper Extremity|Bone of Upper Extremity|Bones of Upper Extremity
C12984	Interval_Lymph_Node	Lymph_Node	Interval Lymph Node	One of the nodes that lie along the course of a lymphatic vessel between a primary melanoma site and a recognized node field. (from Medscape)
C12985	Neural_Stem_Cell	Stem_Cell	Neural Stem Cell|Neural Stem Cells	A stem cell derived from embryonic sources or found in adult neural tissue. It has the capacity to generate all the multiple cell types found in the brain and spinal cord.
C12986	Alveolus	Respiratory_System_Part	Alveolus|Alveoli|Bronchial Alveolus|alveoli	(al-VEE-o-lye) Tiny air sacs at the end of the bronchioles in the lungs.
C12987	Caruncle	Retired_Concepts	Caruncle	A small epidermoid structure of the conjunctiva of the eye that lies near the inner canthus.  It serves as a transition zone between cutaneous and mucous membrane components.
C12988	Cybrid	Retired_Concepts	Cybrid	A hybrid cell with cytoplasm (or cytoplasmic components) of one cell inserted into another cell.
C12989	Episclera	Membrane	Episclera|Episcleral Layer	A thin fibrous membrane that covers the outer surface of the anteriors sclera and contains blood vessels which supply the sclera.
C12990	Lobule	Other_Anatomic_Concept	Lobule|LBUL|lobule	(LOB-yule) A small lobe or subdivision of a lobe.
C12991	Neuroblast	Neuroectodermal_Cell	Neuroblast	An embryonic nerve cell capable of differentiating into a neuron.
C12992	Splenic_Red_Pulp	Splenic_Pulp	Splenic Red Pulp|Red Pulp	Splenic pulp seen grossly as a reddish brown substance, due to its abundance of red blood cells, consisting of splenic sinuses and the tissue intervening between them (splenic cords).
C12993	Splenic_White_Pulp	Lymphoid_Tissue|Splenic_Pulp	Splenic White Pulp|White Pulp	The part of the spleen that consists of nodules and other lymphatic concentrations.
C12994	Thymocyte	T-Lymphocyte	Thymocyte|Thymocytes	A cell that develops in the thymus, seemingly from a stem cell of bone marrow and of fetal liver, and is the precursor of the thymus-derived lymphocyte (T lymphocyte) that effects cell-mediated (delayed type) sensitivity.
C12995	Spinal_Cord_Tract	Spinal_Cord_Part	Spinal Cord Tract|Ascending and Descending Tracts of Spinal Cord|Spinal Cord Tracts|Tracts of Spinal Cord
C12996	Vestibulocochlear_Nerve	Cranial_Nerve	Vestibulocochlear Nerve|Cranial Nerve Eight|Cranial Nerve VIII|Eighth Cranial Nerve|VIIIth Cranial Nerve	The eighth cranial nerve composed of the acoustic nerve and the vestibular nerve.  The nerve travels from the inner ear, enters the cranial cavity through the internal auditory foramen and joins the brainstem.  The auditory nerve conveys impulses from the cochlea of the inner ear to the auditory nuclei of the brainstem.  The vestibular nerve carries information from the labyrinths of the inner ear to the vestibular nuclei of the brainstem.
C12997	Body_Space	Retired_Concepts	Body Space	is a three-dimensional anatomical spatial entity, which is generated by morphogenetic or other physiologic processes that generate anatomical structures; it is enclosed by anatomical structures and contains one or more anatomical structures or body substances. Example(s): celom, thoracic cavity, lesser sac of peritoneum, cavity of right atrium, lumen of blood vessel, mediastinum, anterior compartment of forearm, intervertebral foramen.
C12998	Vertebral_Column	Musculoskeletal_System_Part	Vertebral Column|Spinal Column|Spine	excludes sacrum and coccyx C41.4
C12999	Major_Salivary_Gland	Salivary_Gland	Major Salivary Gland
C13000	Rhabdomyocyte	Muscle_Cell	Rhabdomyocyte|Muscle Fibers|Skeletal Muscle Cell	Large single cells, either cylindrical or prismatic in shape, that form the basic unit of muscle tissue. They consist of a soft contractile substance enclosed in a tubular sheath. (MeSH)
C13001	Smooth_Muscle_Tissue_Cell	Muscle_Cell	Smooth Muscle Cell|Leiomyocyte|Smooth Muscle Tissue Cell	An elongated spindle-shaped contractile cell, peculiar to an involuntary muscle, containing a single nucleus and longitudinally arranged myofibrils.
C13002	Cardiocyte	Striated_Muscle_Tissue_Cell	Cardiomyocyte|Cardiocyte|Heart Muscle Cell	A muscle cell in heart tissue (myocardium).
C13003	Ependymocyte	Glial_Cell	Ependymal Cell|Ependymal Cells|Ependymocyte	A cell that lines cavities in the central nervous system.  It is considered to be a type of glial cell.
C13004	Endocardium	Heart_Part	Endocardium	The innermost layer of the heart, comprised of endothelial cells. (MeSH)
C13005	Pericardium	Membrane	Pericardium	The fibroserous sac surrounding the heart and the roots of the great vessels. (MeSH)
C13006	Specialized_Epithelial_Cell	Epithelial_Cell	Specialized Epithelial Cell|Epithelial Cells, Specialized|Specialized Epithelial Cells	A cell that covers the surface of the body and lines its cavities that has a specific function to perform.
C13007	Gross_Anatomy_Concepts	Retired_Concepts	Gross Anatomy Concepts
C13008	Lymphokine-Activated_Killer_Cell	Biological_Agent	Lymphokine-Activated Killer Cells|Cell, LAK|Cells, LAK|Killer Cells, Lymphokine-Activated|LAK|LAK Cell|LAK Cells|LAK cells|Lymphokine Activated Killer Cell|Therapeutic Lymphokine-Activated Killer Cells|lymphokine-activated killer cells	Killer cell lymphocytes activated in the presence of interleukin-2 (IL-2).  Lymphokine-activated killer cells (LAKs) are cytotoxic effector cells with an exceptionally wide target cell spectrum including normal and malignant cells of different origins.  LAK cells exhibit a profound heterogeneity with regard to phenotype surface marker expression; it remains to be determined if they represent a unique cell lineage.
C13009	Histology_Concepts	Retired_Concepts	Histology Concepts|Histopathology Concepts
C13010	Brunner_s_Gland	Exocrine_Gland	Brunner's Gland|Brunner's Glands	Small, flat, granular glands embedded in the submucous areolar tissue of the duodenum. (MeSH)
C13011	Ampulla_of_Vater	Gastrointestinal_System_Part	Ampulla of Vater|Vater's Ampulla	A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct. (MeSH)
C13012	Lymphoid_Blood-Forming_Cell	Bone_Marrow_Stem_Cell	Lymphoid Blood-Forming Cell|Lymphoid Blood-Forming Cells	A lymphoid blood-forming cell is a hematopoietic stem cell that is a precursor for a T lymphocyte or B lymphocyte.
C13013	Lymphoblast	Blast_Cell|Immature_Lymphocyte	Lymphoblast	An immature lymphocyte that has enlarged in response to antigenic stimulation.
C13014	Monoblast	Blast_Cell|Myeloid_Cell	Monoblast	A cell derived from a myeloid progenitor cell. It differentiates into a promonocyte. It is about 12 to 20 micrometer in diameter, has a round to oval nucleus with fine, lightly dispersed chromatin and one to four nucleoli. The cytoplasm is agranular, stains moderately to lightly basophilic, and often has an intensely stained periphery and a prominent perinuclear zone. Monoblasts are found in bone marrow and never appear in the normal peripheral blood.
C13015	Myeloblast	Blast_Cell|Myeloid_Cell	Myeloblast	An immature cell that represents the first stage in the granulocytic series of hematopoiesis. It is found in bone marrow and differentiates into a promyelocyte. Its nucleus is composed of very fine, evenly distributed chromatin with 2-5 nucleoli. The cytoplasm is basophilic and non-granular.
C13016	Female_Genital_Organ	Retired_Concepts	Female Genital Organ|Female Genital Organs|Female genital organs (all sites)|female genital	The primary female sex organs or genitals.
C13017	Male_Genital_Organ	Other_Anatomic_Concept	Male Genital Organ|Male Genital Organs	The primary male sex organs or genitals.
C13018	Organ	Anatomic_Structure_System_or_Substance	Organ|organ	A part of the body that performs a specific function.  For example, the heart is an organ.
C13019	Eye_Part	Organ_of_Special_Sense_Part	Eye Part
C13020	Breast-Related_Entity	Body_Part	Breast Part|Breast-Related Entity
C13021	Mouth_Part	Retired_Concepts	Mouth Part
C13022	Skin_Part	Integumentary_System_Part	Skin Part
C13023	Heart_Part	Cardiovascular_System_Part	Heart Part
C13024	Pancreas_Part	Other_Anatomic_Concept	Pancreas Part
C13025	Stomach_Part	Other_Anatomic_Concept	Stomach Part
C13026	Intestine_Part	Retired_Concepts	Intestine Part
C13027	Esophagus_Part	Retired_Concepts	Esophagus Part
C13028	Biliary_Tract_Part	Retired_Concepts	Biliary Tract Part
C13029	Endocrine_System_Part	Body_Part	Endocrine System Part
C13030	Gonad_Part	Retired_Concepts	Gonad Part
C13031	Brain_Part	Central_Nervous_System_Part	Brain Part
C13032	Exocrine_System_Part	Retired_Concepts	Exocrine System Part
C13033	Immune_System_Part	Body_Part	Immune System Part
C13034	Lymphatic_System_Part	Retired_Concepts	Lymphatic System Part
C13035	Urinary_System_Part	Body_Part	Urinary System Part
C13036	Stomatognathic_System_Part	Retired_Concepts	Stomatognathic System Part
C13037	Respiratory_System_Part	Body_Part	Respiratory System Part
C13038	Male_Reproductive_System_Part	Reproductive_System_Part	Male Reproductive System Part
C13039	Female_Reproductive_System_Part	Reproductive_System_Part	Female Reproductive System Part
C13040	Nervous_System_Part	Body_Part	Nervous System Part
C13041	Body	Other_Anatomic_Concept	Body|BDY	The entire physical structure of an organism.  It is composed of anatomic systems, regions, cavities, and spaces.
C13042	Organ_System_Part	Retired_Concepts	Organ/System Part
C13043	Ear_Part	Organ_of_Special_Sense_Part	Ear Part
C13044	Joint	Musculoskeletal_System_Part	Joint|Articulation|Joints	The point of connection between two bones or elements of a skeleton, especially if the articulation allows motion.
C13045	Tendon	Aponeurosis	Tendon|Tendons
C13046	Ligament	Musculoskeletal_System_Part	Ligament|Ligaments	Shiny, flexible bands of fibrous tissue connecting together articular extremities of bones. They are pliant, tough, and inextensile. (MeSH)
C13047	Seminiferous_Tubule	Testicular_Tissue	Seminiferous Tubule|Seminiferous Tubules
C13048	Nephron	Renal_Tissue	Nephron|Uriniferous Tube	The functional units of the kidney, consisting of the glomerulus and the attached tubule. (MeSH)
C13049	Lymphoid_Tissue	Hematopoietic_and_Lymphoid_Tissue	Lymphoid Tissue	Tissue characterized by the presence of large numbers of lymphocytes in different stages of transformation. Connective tissue cells including fibroblasts and macrophages may be present. Lymphoid tissue is framed by a network of reticular fibers and may be diffuse, or densely aggregated.
C13050	Skeletal_Muscle_Tissue	Striated_Muscle_Tissue	Skeletal Muscle Tissue|Skeletal Muscle	Striated muscles that are under voluntary control of the organism.  They are connected at either or both ends to a bone and are utilized for locomotion and other movements.
C13051	Hematopoietic_Tissue	Hematopoietic_and_Lymphoid_Tissue	Hematopoietic Tissue|hematopoietic tissue	Tissue in which new blood cells are formed.
C13052	Nervous_Tissue	Nerve_Tissue_and_Nerve_Sheaths	Nerve Tissue|Nervous Tissue	The tissue that generates and conducts electrical signals in the body.  It contains the neurons.
C13053	Vascular_Endothelium	Endothelium	Vascular Endothelium	Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components from interstitium to lumen. (MeSH)
C13054	Embryonic_Cell	Cell|Embryonic_Structure	Embryonic Cell|Blastomere|Embryonic Cells	A cell formed in the first stages of embryonic development, after the splitting of the fertilized ovum, but before the formation of the blastula or blastocyst.
C13055	Secretory_Cell	Cell	Secretory Cell	One of several types of cells that generate and secrete a substance to be used by the organism.
C13056	Muscle	Musculoskeletal_System_Part	Muscle|MM	Muscle; one of the contractile organs of the body.
C13057	Reticular_Cell	Connective_and_Soft_Tissue_Cell	Reticular Cell|Reticular Cells	A cell with processes making contact with those of other similar cells to form a cellular network sheathing a network of reticular fibers, which constitutes the stroma of all lymphoid organs except the thymus
C13058	Special_Sense_Organ_System	Other_Anatomic_Concept	Special Sense Organ System
C13059	Synovial_Cell	Connective_and_Soft_Tissue_Cell	Synovial Cell|Synovial Cells	A fibroblast that lies between the cartilaginous fibers in the synovial membrane of joints.
C13060	Sensory_Ganglion	Ganglion	Sensory Ganglion|Sensory Ganglia	Clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons. Sensory ganglia may also have intrinsic interneurons and non-neuronal supporting cells. (MeSH)
C13061	Chromaffin_System	Retired_Concepts	Chromaffin System	The cells of the body which stain with chromium salts. They occur along the sympathetic nerves, in the adrenal gland, and in various other organs.
C13062	Back	Body_Region	Back
C13063	Neck	Body_Region	Neck	The region that connects the head to the rest of the body.
C13064	Digestive_System	Retired_Concepts	Digestive System|Digestive System (All Sites)	encompasses the mouth, esophagus, stomach, intestines, biliary tract, pancreas, liver, and associated hormones and secretions.
C13065	Sphincter_of_Oddi	Gastrointestinal_Sphincter	Sphincter of Oddi|Glisson's Sphincter|Oddi's Sphincter	The muscle fibres around the opening of the common bile duct (ductus choledochus) into the duodenum at the papilla of Vater.
C13066	Ileocecal_Valve	Gastrointestinal_System_Part	Ileocecal Valve
C13067	Solitary_Nucleus	Brain_Part	Solitary Nucleus|Nucleus Tractus Solitarius|Nucleus of the Solitary Tract|Nucleus of the Tractus Solitarius	Gray matter located in the dorsomedial part of the medulla oblongata associated with the solitary tract. The solitary nucleus receives inputs from most organ systems including the terminations of the facial, glossopharyngeal, and vagus nerves. It is a major coordinator of autonomic nervous system regulation of cardiovascular, respiratory, gustatory, gastrointestinal, and chemoreceptive aspects of homeostasis. The solitary nucleus is also notable for the large number of neurotransmitters which are found therein. (MeSH)
C13068	Foot_Bone	Bone_of_the_Lower_Extremity	Foot Bone|Foot Bones	The tarsus, metatarsus, and phalanges. (MeSH)
C13069	Stomatognathic_System	Other_Anatomic_Concept	Stomatognathic System	The mouth, teeth, jaws, pharynx, and related structures as they relate to mastication, deglutition, and speech. (MeSH)
C13070	Cheek	Head_and_Neck_Part	Cheek
C13071	Face	Musculoskeletal_System_Part	Face	The anterior portion of the head that includes the skin, muscles, and structures of the forehead, eyes, nose, mouth, cheeks, and jaw. (MeSH)
C13072	Dentition	Head_and_Neck_Part	Dentition	The teeth collectively in the dental arch. Dentition ordinarily refers to the natural teeth in position in their alveoli. (MeSH)
C13073	Facial_Muscle	Head_and_Neck_Muscle	Facial Muscle|Facial Muscles	Muscles of facial expression or mimetic muscles that include the numerous muscles supplied by the facial nerve that are attached to and move the skin of the face. (MeSH)
C13074	Masseter_Muscle	Muscle_of_the_Mastication	Masseter Muscle|Masticatory Muscle|Masticatory Muscles	Muscles arising in the zygomatic arch that close the jaw. (MeSH)
C13075	Pharyngeal_Muscle	Head_and_Neck_Muscle	Pharyngeal Muscle|Pharyngeal Muscles	The muscles of the pharynx, the inferior, middle and superior constrictors, salpingopharyngeus, and stylopharyngeus. (MeSH)
C13076	Bone_Tissue	Connective_Tissue	Bone Tissue
C13077	Acinar_Cell	Glandular_Cell	Acinar Cell|Aciner Cells	any of the cells lining an acinus; acinus is a general term used to designate a small saclike dilatation, particularly one found in various glands.
C13078	Ependyma	Ependyma_and_Remnants_of_the_Central_Canal_of_the_Spinal_Cord	Ependyma|Ependymal Tissue	A thin membrane that lines the ventricles of the brain and the central canal of the spinal cord.
C13079	Neural_Pathway	Peripheral_Nervous_System_Part	Neural Pathway|Neural Pathways	Neural tracts connecting one part of the nervous system with another. (MeSH)
C13080	Afferent_Pathway	Neural_Pathway	Afferent Pathway|Afferent Pathways	Nerve structures through which impulses are conducted from a peripheral part toward a nerve center. (MeSH)
C13081	Efferent_Pathway	Neural_Pathway	Efferent Pathway|Efferent Pathways	Nerve structures through which impulses are conducted from a nerve center toward a peripheral site. (MeSH)
C13082	Internal_Capsule	Brain_Part|Organ_Capsule	Internal Capsule	White matter pathway, flanked by nuclear masses, consisting of both afferent and efferent fibers projecting between the cerebral cortex and the brainstem. It consists of three distinct parts: the anterior limb, posterior limb, and genu. (MeSH)
C13083	Medial_Forebrain_Bundle	Neural_Pathway	Medial Forebrain Bundle	A complex group of fibers arising from the basal olfactory regions, the periamygdaloid region, and the septal nuclei, and passing to the lateral hypothalamus. (MeSH)
C13084	Perforant_Pathway	Neural_Pathway	Perforant Pathway|Perforating Fasciculus	A pathway of fibers originating in the lateral part of the entorhinal area, perforating the subiculum of the hippocampus, and running into the stratum moleculare of the hippocampus, where these fibers synapse with others that go to the dentate gyrus. It is also called the perforating fasciculus. (MeSH)
C13085	Alveolar_Wall	Respiratory_System_Part	Alveolar Wall
C13086	Capsule_of_the_Prostate	Male_Reproductive_System_Part|Organ_Capsule	Prostate Capsule|Capsule of Human Prostate|Capsule of the Prostate
C13087	Apex_of_the_Prostate	Male_Reproductive_System_Part	Apex of the Prostate|Apex of Human Prostate
C13088	Base_of_the_Prostate	Male_Reproductive_System_Part	Base of the Prostate|Base of Human Prostate
C13089	Anterior_Surface_of_the_Prostate	Surface_of_the_Prostate	Anterior Surface of the Prostate|Anterior Surface of Human Prostate
C13090	Inferolateral_Surface_of_the_Prostate	Surface_of_the_Prostate	Inferolateral Surface of the Prostate|Inferolateral Surface of Human Prostate
C13091	Surface_of_the_Prostate	Anatomic_Surface|Male_Reproductive_System_Part	Surface of the Prostate|Surface of Human Prostate
C13092	Lateral_Lobe_of_the_Prostate	Male_Reproductive_System_Part	Lateral Lobe of the Prostate|Lateral Lobes of Human Prostate
C13093	Posterior_Lobe_of_the_Prostate	Male_Reproductive_System_Part	Posterior Lobe of the Prostate|Posterior Lobe of Human Prostate
C13094	Middle_Lobe_of_the_Prostate	Male_Reproductive_System_Part	Middle Lobe of the Prostate|Median Lobe of Human Prostate
C13095	Posterior_Surface_of_the_Prostate	Surface_of_the_Prostate	Posterior Surface of the Prostate|Posterior Surface of Human Prostate
C13096	Prostatic_Glandular_Tissue	Other_Anatomic_Concept	Prostatic Glandular Tissue|Human Prostatic Glandular Tissue
C13097	Mucosal_Tissue_of_Human_Prostate	Prostatic_Glandular_Tissue	Mucosal Tissue of Human Prostate
C13098	Orifice_of_Human_Prostatic_Duct	Other_Anatomic_Concept	Orifice of Human Prostatic Duct
C13099	Submucosal_Tissue_of_Human_Prostate	Prostatic_Glandular_Tissue	Submucosal Tissue of Human Prostate
C13100	Prostatic_Muscular_Tissue	Smooth_Muscle_Tissue	Prostatic Muscular Tissue|Human Prostatic Muscular Tissue	The supporting structure for the prostate. A dense layer of smooth muscle tissue lies directly underneath the fibrous capsule and another dense layer of circular fibers surrounds the urethra (striated and smooth). In between these two layers is a mesh of smooth muscle tissue in which the prostatic glands are embedded.
C13101	Prostatic_Portion_of_the_Male_Urethra	Urinary_System_Part	Prostatic Urethra|Prostatic Portion of the Male Urethra
C13102	Prostatic_Duct	Duct	Prostatic Duct|Human Prostatic Duct
C13103	Prostatic_Epithelium	Epithelium	Prostatic Epithelium|Epithelium of Human Prostate Gland	Tissue composed of one or more layers of epithelial cells and a basement membrane. It lines the secretory alveoli and secretory ducts of the prostate. The secretory epithelium consists mostly of pseudostratified columnar cells and basal cells with areas of cuboidal and squamous epithelial cells. The walls of the prostatic urethra and the distal regions of the longer ducts are lined with transitional epithelium.
C13104	Prostatic_Stroma	Prostatic_Tissue	Prostatic Stroma|Stroma of Human Prostate Gland|Stroma of the Prostate Gland	The non-glandular tissue of the prostate gland, consisting of two major cell types, smooth muscle cells and fibroblasts. Stromal cells are key regulators of growth and differentiation in the prostate.
C13106	Human_Veru_Montanum	Other_Anatomic_Concept	Human Veru Montanum
C13107	Wall_of_Human_Prostatic_Duct	Male_Reproductive_System_Part	Wall of Prostatic Duct|Wall of Human Prostatic Duct
C13108	Fascia	Musculoskeletal_System_Part	Fascia
C13112	Macrocyte	Abnormal_Red_Blood_Cell	Macrocytic Red Blood Cell|Macrocyte|Macrocytes	An abnormally large red blood cell occurring mainly in anemias (as pernicious anemia), also called megalocyte.  Lack of vitamin B12 and folic acid could also cause macrocytes. (NCI)
C13113	Immature_Granulocyte	Granulocyte	Immature Granulocyte	A not-yet-mature white blood cell with staining granules in its cytoplasm. The staining granules may be neutrophilic, acidophilic, or basophilic in character. There are indications that an immature granulocyte count is a better measure of infection and sepsis than a total white blood cell count and comparable to absolute neutrophil count.
C13114	Promyelocyte	Granulocyte	Promyelocyte	A cell of the bone marrow that is derived from myeloblasts and will give rise to myelocytes, precursors of myeloid cells and neutrophil granulocytes.
C13115	Myelocyte	Granulocyte	Myelocyte	A cell derived from a promyelocyte. It differentiates into a metamyelocyte. It has a diameter of 10-18 micrometer, and an oval or round nucleus with finely granulated chromatin.
C13116	Metamyelocyte	Granulocyte	Metamyelocyte	A cell derived from a promyelocyte and differentiates into a neutrophil. It is nonproliferative and is usually found in bone marrow. Its nucleus is indented and the chromatin clumped and dense.
C13117	Band_Cell	Granulocyte	Band Cell	A late precursor of a granulocyte in which the nucleus is in the form of a curved or coiled band, not having acquired the typical multilobar shape of the mature polymorphonuclear neutrophil.
C13118	Immature_Lymphocyte	Lymphocyte	Immature Lymphocyte	A cell that develops from hematopoietic stem cells. An immature lymphocyte represents of one of five stages of lymphocyte maturation. It is estimated 90% of immature lymphocytes die in the thymus and bone marrow.
C13119	Prolymphocyte	Lymphocyte	Prolymphocyte|PROLYP	A medium-sized round lymphocyte of B or T-cell lineage with prominent nucleoli.  It is an intermediate cell between the lymphoblast and the small, mature lymphocyte.
C13120	Immature_Monocyte	Monocyte	Immature Monocyte	A cell derived from a myeloid stem cell. It is the representation of one stage of monocyte development.
C13121	Promonocyte	Immature_Monocyte	Promonocyte
C13122	Megakaryoblast	Blast_Cell|Myeloid_Cell	Megakaryoblast|Megacaryoblast	The precursor of a megakaryocyte.
C13123	Memory_B_Cell	Mature_B-Lymphocyte	Memory B-Lymphocyte|Memory B Cell
C13124	Epithelial_Reticular_Cell	Epithelial_Cell	Epithelial Reticular Cell|Epithelial Reticular Cells	A branched epithelial cell that supports epithelial structures.
C13126	Immature_Platelet	Platelet	Immature Platelet	A young platelet that contains residual mRNA and rRNA when released from the bone marrow into the peripheral circulation as a result of thrombopoiesis. Immature platelets normally make up a small percentage of the total circulating platelets (1.1-6.1%, with a mean of 3.4%.). An increased proportion of immature platelets in blood indicates increased thrombopoiesis. The relationship between the percent of immature platelets and the platelet count can be used to determine the rate of platelet turnover.
C13127	_7p15-p14	Chromosome_Band	7p15-p14	A chromosome band present on 7p
C13128	_7q35	Chromosome_Band	7q35	A chromosome band present on 7q
C13129	Proerythroblast	Myeloid_Cell	Proerythroblast	The earliest of four stages in development of the normoblast.
C13130	Basophilic_Erythroblast	Erythroblast	Basophilic Erythroblast	A nucleated red blood cell that stains readily with basic dye.
C13131	Polychromatophilic_Erythroblast	Erythroblast	Polychromatophilic Erythroblast
C13132	Orthochromatophilic_Erythroblast	Erythroblast	Orthochromatophilic Erythroblast	A cell derived from a polychromatophilic erythroblast in bone marrow. It has a dense nucleus and its cytoplasm is approaching the color of a mature erythrocyte. It differentiates into a reticulocyte when it extrudes its nucleus.
C13134	_2q37	Chromosome_Band	2q37	A chromosome band present on 2q
C13135	Xp11_23	Chromosome_Band	Xp11.23	A chromosome band present on Xp
C13136	_19q13_2-q13_3	Chromosome_Band	19q13.2-q13.3	A chromosome band present on 19q
C13137	_13q33	Chromosome_Band	13q33	A chromosome band present on 13q
C13138	_16p13_3-p13_11	Chromosome_Band	16p13.3-p13.11	A chromosome band present on 16p
C13139	_3q22-q24	Chromosome_Band	3q22-q24	A chromosome band present on 3q
C13140	_7q11-q22	Chromosome_Band	7q11-q22	A chromosome band present on 7q
C13141	Ependymal_Cell	Retired_Concepts	Ependymal Cell|Ependymal Cells
C13142	Mucus-Secreting_Cell	Glandular_Cell|Secretory_Cell	Mucus-Secreting Cell	It is the epithelium cell that produces mucin gel adherent to the mucosal surface. Mucus-secreting cells are widely distributed through the body. (NCI)
C13143	Clara_Cell	Glandular_Cell	Clara Cell|Nonciliated Bronchiolar Epithelial Cell	A rounded, club-shaped, nonciliated cell found in between ciliated cells in the epithelium of respiratory and terminal bronchioles. It has a secretory function.
C13144	Squamous_Alveolar_Lining_Cell	Alveolar_Cell|Squamous_Cell	Squamous Alveolar Lining Cell|Squamous Alveolar Lining Cells	A flat, scale-like epithelial cell that forms the inner lining of the alveoli.
C13145	Epithelial_Receptor_Cell	Epithelial_Cell	Epithelial Receptor Cell	A cell on the surface of the body or lining a body cavity that responds to physical and chemical stimuli by sending information to the central nervous system.
C13146	Type_I_Cell	Epithelial_Cell	Intercalated Cell|Dark Cell|Intercalated Cells	The intercalated cell is an epithelial cell of the renal collecting tubule that is specialized for H+ and HCO3 transport. These cells exist in two types, [alpha] and [beta]. The [alpha] cell secretes H+ into the lumen by an apical H+ ATPase and a basolateral Cl:HCO3. The [beta] cell secretes HCO3- into the lumen by an apical Cl:HCO3 and a basolateral H+ ATPase.
C13147	Taste_Bud_Cell	Epithelial_Receptor_Cell	Taste Bud Cell|Taste Bud Cells|Taste-Bud	One of three types of cells in a taste bud - sensory, supporting or basal. The sensory cell has receptors on its apical surface. The receptors are transmembrane proteins which bind to the molecules and ions that give rise to the 5 taste sensations. Although a single taste cell may have representatives of several types of receptor, one type may be more active than the others, but no single taste cell contains receptors for both bitter and sweet tastants. Each taste receptor cell is connected to a sensory neuron leading back to the brain. The supporting cell has microvilli and appears to secrete substances into lumen of taste bud.
C13148	Light_Cell	Epithelial_Cell	Light Cell	A cell located in the collecting tube of the nephron..
C13149	Type_III_Epithelial_Receptor_Cell	Taste_Bud_Cell	Type III Epithelial Receptor Cell|Type III Cell	A light cell found in taste buds, characterized by afferent synaptic specializations to intragemminal nerve endings including increased density of the plasma membrane along the nerve and aggregations of synaptic vesicles, and by the presence of cored vesicles of 80-150 nm in diameter. The core is dense and the cell is immunoreactive for 5-hydroxytryptamine, neural cell adhesion molecule, and PGP 9.5.
C13150	Olfactory_Epithelial_Cell	Epithelial_Cell	Olfactory Epithelial Cell|Olfactory Epithelial Cells	A cell found in the pseudostratified epithelium lining the olfactory region of the nasal cavity. The olfactory epithelium has three major cell types - olfactory receptor cells, basal cell and sustentacular cells.
C13151	Olfactory_Cell	Bipolar_Neuron|Neuroectodermal_Cell	Olfactory Receptor Cell|Olfactory Receptor Cells	A specialized, fusiform nerve cell with a large nucleus, embedded among the epithelial cells in the mucous membrane of the nose; it carries impulses from the olfactory receptors to the glomeruli in the olfactory bulb.
C13152	Supporting_Cell	Olfactory_Epithelial_Cell	Olfactory Supporting Cell	A cell that serves to provide support and protection to the olfactory epithelium.
C13153	Olfactory_Basal_Cell	Olfactory_Epithelial_Cell	Olfactory Basal Cell|Olfactory Basal Cells	A cell found in the pseudostratified epithelium lining the olfactory region of the nasal cavity. It gives rise to olfactory receptor cells and sustentacular cells.
C13154	Bipolar_Neuron	Neuron	Bipolar Neuron|Bipolar Neurons	A nerve cell with two processes.
C13155	Ganglion_Cell	Neuron	Ganglion Cell|Ganglion Cells	A type of interneuron that conveys information to the brain.
C13156	Receptor_Cell	Cell	Receptor Cell
C13157	Cuboidal_Cell	Glandular_Cell	Cuboidal Cell|Cuboidal Cells	A cube-shaped epithelial cell. Because a cuboidal cell has a relatively large cytoplasmic volume, it can undertake more complex functions such as absorption and secretion. Most glandular secretory cells are cuboidal epithelial cells and the ducts of most exocrine glands and kidney tubules are lined by cuboidal cells.
C13158	Columnar_Cell	Glandular_Cell	Columnar Cell|Columnar Cells	An epithelial cell that is taller than it is wide. The nucleus is oval, usually situated at the base of the cell. These cells line large glands and ducts.
C13159	Mesangial_Cell	Phagocytic_Cell	Mesangial Cell	Cell found within the glomerular lobules of mammalian kidney. Mesangial cells serve as structural supports, may regulate blood flow, are phagocytic and may act as accessory cells, presenting antigen in immune responses.
C13160	Intercalated_Cell	Retired_Concepts	Intercalated Cell|Intercalated Cells	The intercalated cell is an epithelial cell of the renal collecting tubule that is specialized for H+ and HCO3 transport. These cells exist in two types, [alpha] and [beta]. The [alpha] cell secretes H+ into the lumen by an apical H+ ATPase and a basolateral Cl:HCO3. The [beta] cell secretes HCO3- into the lumen by an apical Cl:HCO3 and a basolateral H+ ATPase.
C13161	Juxtaglomerular_Cell	Cell	Juxtaglomerular Cell	Any of a group of cells that are situated in the wall of each afferent arteriole of a kidney glomerulus near its point of entry adjacent to a macula densa and that produce and secrete renin.(Online Medical Dictionary)
C13164	Epicardium	Heart_Part	Epicardium
C13165	Organ_Layer	Retired_Concepts	Organ Layer
C13166	Mucosa	Membrane	Mucosa|Mucous Membrane|mucosa|mucous membrane	The moist tissue that lines some organs and body cavities (such as the nose, mouth, lungs) and makes mucus (a thick, slippery fluid).
C13167	Submucosa	Tissue	Submucosa	A layer of areolar tissue beneath the mucous membrane
C13168	Muscularis_Externa	Retired_Concepts	Muscularis Externa
C13169	Serosa	Membrane	Serosa|Serous Membrane	A membrane lining the external walls of the body cavities and reflected over the surfaces of protruding organs. It consists of mesothelium lying on a connective tissue layer, and secretes a watery exudate.
C13170	Hassall_s_Corpuscle	Thymic_Tissue	Hassall's Corpuscle|Hassall's Body|Hassall's Concentric Corpuscle|Thymic Corpuscle|Virchow-Hassall Body	A small spherical body composed of keratinized squamous epithelial cells arranged in a concentric pattern in the medullary portion of the thymus.
C13171	Meissner_Corpuscle	Skin_Part	Meissner Corpuscle|Corpusculum Tactus|Meissner's Corpuscle|Oval Corpuscle|Tactile Corpuscle|Touch Corpuscle	One of numerous oval bodies found in the papillae of the skin, especially those of the fingers and toes; they consist of a connective tissue capsule in which the axon fibrils terminate around and between a pile of wedge-shaped epithelioid cells. SYN corpusculum tactus, oval corpuscle, touch corpuscle. (On-line Medical Dictionary)
C13172	Vater-Pacini_Corpuscle	Skin_Part	Vater-Pacini Corpuscle|Corpuscula Lamellosa|Lamellated Corpuscle|Pacinian Corpuscle|Vater's Corpuscle	A specialized bulblike nerve ending located in the subcutaneous tissue of the skin; occurs abundantly in the skin of palms and soles and joints and genitals.
C13173	Merkel_s_Corpuscle	Skin_Part	Merkel's Corpuscle|Meniscus Tactus|Merkel's Tactile Cell|Tactile Disk|Tactile Meniscus	A specialized tactile sensory nerve ending in the epidermis, characterized by a terminal cuplike expansion of an intraepidermal axon in contact with the base of a single modified keratinocyte. SYN meniscus tactus, Merkel's corpuscle, Merkel's tactile cell, Merkel's tactile disk, tactile disk. (On-line Medical Dictionary)
C13174	Free_Nerve_Ending	Peripheral_Nervous_System_Part	Free Nerve Ending|Free Nerve Endings	Free nerve endings are widely distributed throughout the body, and are found as branches of unmyelinated, or lightly myelinated fibres grouped in bundles beneath the epithelium. As they penetrate the epithelium, they lose their myelin, and branch among the epithelial cells. Branches of one nerve may cover a wide area and overlap the territories of other nerves. The free nerve endings detect pain, touch, pressure and temperature, and are associated with C fibres.
C13175	Ruffinis_Corpuscle	Skin_Part	Ruffini's Corpuscle|Ruffini's Ending
C13176	Nociceptor	Somatosensory_Receptor	Nociceptor|Nociceptors|Pain Receptor	A free nerve ending that is a receptor for painful stimuli. (Kanner)
C13177	Pigment_Epithelium	Epithelium	Pigment Epithelium|Pigmented Epithelium	Tissue consisting of one or more layers of epithelial cells and a basement membrane. The cells contain granules of pigment or melanin, as in the retinal or iris pigment layer.
C13178	Simple_Squamous_Epithelium	Simple_Epithelium|Squamous_Epithelium	Simple Squamous Epithelium	Epithelium composed of a single layer of flat cells wider than they are tall. This epithelium is found in anatomic sites where exchange of nutrients, wastes and gases occur.
C13179	Basilar_Membrane	Membrane	Basilar Membrane	A sheet of amorphous extracellular material upon which the basal surfaces of epithelial cells rest. It is made up of two layers, the basal lamina and the reticular lamina. It is also associated with muscle cells, Schwann cells, fat cells, and capillaries; and is interposed between the cellular elements and the underlying connective tissue.
C13180	Stratified_Squamous_Epithelium	Squamous_Epithelium|Stratified_Epithelium	Stratified Squamous Epithelium	Epithelium consisting of multiple layers of cells that are flattened and more cuboidal toward the base. Its function is protection. Outer layers may be dead and hardened (keratinized) such as with skin or on top of wet, mucous surfaces such as the cornea
C13181	Pseudostratified_Columnar_Ciliated_Epithelium	Columnar_Epithelium|Pseudostratified_Epithelium	Pseudostratified Columnar Ciliated Epithelium	Epithelium composed of a single layer of cells, appearing as layered because the column-shaped cells vary in height so the nuclei are at different levels. The basal portions of all the cells are in contact with the basement membrane. It lines the respiratory system and the male reproductive tract. The cilia in the respiratory tract are motile, while the stereocilia in the male reproductive tract are immobile.
C13182	Columnar_Epithelium	Glandular_Epithelium	Columnar Epithelium
C13183	Endosteum	Bone_Tissue	Endosteum
C13184	Periosteum	Bone_Tissue	Periosteum	The outer membrane that surrounds a bone. It contains connective tissue, capillaries, nerves, and a number of types of cell, including osteoclasts. The periosteum plays an important role in bone repair and growth.
C13185	Taste_Bud_Basal_Cell	Taste_Bud_Cell	Taste Bud Basal Cell	A small, round cell found in the lower part of the epidermis of the taste bud. It differentiates into a new receptor cell and renewed about every 10 days.
C13186	A-DNA	DNA_Structure	A-DNA|A-Form DNA	A-DNA is a shorter and wider helix than B-DNA. Most RNA and RNA-DNA duplex are in this form. While deep, narrow major groove is not easily accessible to proteins but wide, shallow minor groove is accessible to proteins but with lower information content than major groove. A-DNA is the favored conformation at low water concentrations. Base pairs are tilted to helix axis and displaced from axis and sugar pucker is C3'-endo (in RNA 2'-OH inhibits C2'-endo conformation). When examined from the top of the helix, there is a large hole in the middle, the sugar phosphate backbone is at the edge of the helix, and the bases are displaced towards the edge.
C13187	Protein_Sequence	Protein_Structure	Protein Sequence|Primary Protein Structure|amino acid sequence	The arrangement of amino acids in a protein.  Proteins can be made from 20 different kinds of amino acids, and the structure and function of each type of protein are determined by the kinds of amino acids used to make it and how they are arranged.
C13188	Amniotic_Fluid	Embryonic_Fluid	Amniotic Fluid|Aqua Amnii|Liquor Amnii|Waters (Amniotic Fluid)	The fluid within the amniotic cavity which surrounds and protects the developing embryo.  It is initially produced by the amnion and then later by the lungs and kidneys.  The amount at term normally varies from 500 to 2000 ml.
C13189	Epitopes	Protein_Domain	Epitopes|Antigenic Determinant|Antigenic Determinants|Binding Determinants|epitope	(EP-i-tope) A part of a molecule that an antibody will recognize and bind to.
C13190	Aqueous_Humor	Body_Fluid_or_Substance	Aqueous Humor
C13191	Basement_Membrane	Epithelium_Part|Membrane	Basement Membrane	Ubiquitous supportive tissue adjacent to epithelium and around smooth and striated muscle cells. This tissue contains intrinsic macromolecular components such as collagen, laminin, and sulfated proteoglycans. As seen by light microscopy one of its subdivisions is the basal (basement) lamina.
C13192	Bile	Intestinal_Secretion	Bile|Bile Juice|bile	A fluid made by the liver and stored in the gallbladder. Bile is excreted into the small intestine, where it helps digest fat.
C13193	Antibody_Binding_Site	Immunoglobulin_Domain	Antibody Binding Site
C13194	Blood-Brain_Barrier	Central_Nervous_System_Part	Blood-Brain Barrier|BBB|Blood Brain Barrier|blood-brain barrier	A network of blood vessels with closely spaced cells that makes it difficult for potentially toxic substances (such as anticancer drugs) to penetrate the blood vessel walls and enter the brain.
C13195	Bronchoalveolar_Lavage_Fluid	Specimen	Bronchoalveolar Lavage Fluid
C13196	Nucleolus	Cell_Part	Nucleolus	Within most types of eukaryotic CELL NUCLEUS, a distinct region, not delimited by a membrane, in which some species of rRNA (RNA, RIBOSOMAL) are synthesized and assembled into ribonucleoprotein subunits of ribosomes. In the nucleolus rRNA is transcribed from a nucleolar organizer, i.e., a group of tandemly repeated chromosomal genes which encode rRNA and which are transcribed by RNA polymerase I.
C13197	Nucleus	Cell_Structure	Nucleus|Cell Nucleus	A body within the cell, surrounded by a membrane, within which lie the chromosomes, one or more nucleoli, combined with proteins, and exhibits mitosis.  A cell may contain more than one nucleus.
C13198	Centromere	Cell_Part	Centromere	The nonstaining primary constriction of a chromosome which is the point of attachment of the spindle fiber; provides the mechanism of chromosome movement during cell division; the centromere divides the chromosome into two arms, and its position is constant for a specific chromosome: near one end (acrocentric), near the center (metacentric), or between (submetacentric).
C13199	Chloroplast	Experimental_Organism_Anatomical_Concepts	Chloroplast	Photosynthetic organelle containing chlorophyll, the photosynthetic pigment, in cells of leaves and young stems of higher plants. Lens-shaped and rather variable in size but approximately 5 m long. Surrounded by a double membrane and contains circular DNA (though not enough to code for all proteins in the chloroplast). Like the mitochondrion, it is semi-autonomous. It resembles a cyanobacterium from which, on the endosymbiont hypothesis, it might be derived. Chlorophyll is associated with the membrane of vesicles (thylakoids) that are stacked to form grana.
C13200	Chromatid	Cell_Part	Chromatid	One of the two side by side replicas produced by chromosome replication in mitosis or meiosis. Subunit of a chromosome after replication and prior to anaphase of meiosis II or mitosis. At anaphase of meiosis II or mitosis when the centromeres divide and the sister chromatids separate each chromatid becomes a chromosome. (Biology-Text.com)
C13201	Chromatin	Cell_Part	Chromatin	The genetic material of the nucleus, consisting of deoxyribonucleoprotein, which occurs in two forms during the phase between mitotic divisions: 1) as heterochromatin, seen as condensed, readily stainable clumps; 2) as euchromatin, dispersed lightly staining or nonstaining material. During mitotic division the chromatin condenses into chromosomes.
C13202	Chromosome	DNA_Structure	Chromosome|CS|chromosome	(KRO-mo-some) Part of a cell that contains genetic information. Except for sperm and eggs, all human cells contain 46 chromosomes.
C13203	Human_Chromosome	Chromosome	Human Chromosome
C13204	Chromosome_1	Human_Chromosome	Chromosome 1	One of the three pairs in the first group (or group A) of human chromosomes according to the current classification for humans.
C13205	Chromosome_10	Human_Chromosome	Chromosome 10	One of the seven pairs in the third group (or group C) of human chromosomes according to the current classification for humans.
C13206	Chromosome_11	Human_Chromosome	Chromosome 11
C13207	Chromosome_12	Human_Chromosome	Chromosome 12
C13208	Chromosome_13	Human_Chromosome	Chromosome 13
C13209	Chromosome_14	Human_Chromosome	Chromosome 14	One of three pairs in the fourth group (or group D) of human chromosomes according to the current classification for humans.
C13210	Chromosome_15	Human_Chromosome	Chromosome 15
C13211	Chromosome_16	Human_Chromosome	Chromosome 16	One of the three pairs in the fifth group (or group E) of human chromosomes according to the current classification for humans.
C13212	Chromosome_17	Human_Chromosome	Chromosome 17	One of the three pairs in the fifth group (or group E) of human chromosomes according to the current classification for humans.
C13213	Chromosome_18	Human_Chromosome	Chromosome 18
C13214	Chromosome_19	Human_Chromosome	Chromosome 19	One of the two pairs in the sixth group (or group F) of human chromosomes according to the current classification for humans.
C13215	Chromosome_2	Human_Chromosome	Chromosome 2	One of the three pairs in the first group (or group A) of human chromosomes according to the current classification for humans.
C13216	Chromosome_20	Human_Chromosome	Chromosome 20	One of the two pairs in the sixth group (or group F) of human chromosomes according to the current classification for humans.
C13217	Chromosome_21	Human_Chromosome	Chromosome 21	One of the two pairs in the seventh group (or group G) of human chromosomes according to the current classification for humans.
C13218	Chromosome_22	Human_Chromosome	Chromosome 22
C13219	Chromosome_3	Human_Chromosome	Chromosome 3	One of the three pairs in the first group (or group A) of human chromosomes according to the current classification for humans.
C13220	Chromosome_4	Human_Chromosome	Chromosome 4	One of the two pairs in the second group (or group B) of human chromosomes according to the current classification for humans.
C13221	Chromosome_5	Human_Chromosome	Chromosome 5	One of the two pairs in the second group (or group B) of human chromosomes according to the current classification for humans.
C13222	Chromosome_6	Human_Chromosome	Chromosome 6	One of the seven pairs in the third group (or group C) of human chromosomes according to the current classification for humans.
C13223	Chromosome_7	Human_Chromosome	Chromosome 7	One of the seven pairs in the third group (or group C) of human chromosomes according to the current classification for humans.
C13224	Chromosome_8	Human_Chromosome	Chromosome 8	One of the seven pairs in the third group (or group C) of human chromosomes according to the current classification for humans.
C13225	Chromosome_9	Human_Chromosome	Chromosome 9	One of the seven pairs in the third group (or group C) of human chromosomes according to the current classification for humans.
C13226	Cytoplasm	Cell_Structure	Cytoplasm|cytoplasm	That portion of the cell contained within the plasma membrane but excluding the nucleus.
C13227	Cytoskeleton	Nonmembranous_Cytoplasmic_Organelle	Cytoskeleton|Cellular Matrix|Cytoskeletal System	The protein scaffolding (the network of filaments microfilaments, microtubules, intermediate filaments, and their associated proteins) give shape, structure, and organization to the cytoplasm and a cell its shape.
C13228	Satellite_DNA	Repetitive_Sequence	Satellite DNA	DNA that contains many tandem highly repetitive sequences, that have a base composition (and thus density) sufficiently different from that of normal DNA that it sediments as a distinct band in cesium chloride density gradients.  Satellite DNA is located at very specific spots in the genome (on chromosomes 1, 9, 16 and the Y chromosome, the tiny short arms of chromosomes 13-15 and 21 and 22, and near the centromeres of chromosomes). (On-line Medical Dictionary)
C13229	Embryonic_Structure	Embryologic_Structure_or_System	Embryonic Structure|Embryologic Structure
C13230	Endoplasmic_Reticulum	Membranous_Cytoplasmic_Organelle	Endoplasmic Reticulum|ER	The endoplasmic reticulum is a network of tubular membranes within the cytoplasm of the cell, occurring either with a smooth surface (smooth endoplasmic reticulum) or studded with ribosomes (rough endoplasmic reticulum), involved in the transport of materials. (Infoplease Dictionary)
C13231	Exon	Gene_Structure	Exon	The sequences of a gene that are present in the final, mature, spliced messenger RNA molecule from that gene.
C13232	Extracellular_Matrix	Connective_Tissue|Extracellular_Structure	Extracellular Matrix|Cell-Extracellular Matrix	The extracellular matrix is a network of fibers that hold cells together. It is found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere. It is broken down during normal physiological and disease processes such as bone remodeling, embryogenesis, cancer, and arthritis.
C13233	Exudate	Other_Anatomic_Concept	Exudate	Material, such as purulent and nonpurulent fluid, cells, or cellular debris, which has escaped from blood vessels and has been deposited in tissues or on tissue surfaces, usually as a result of inflammation.  An exudate, in contrast to a transudate, is characterized by a relatively high protein content.
C13234	Feces	Body_Fluid_or_Substance	Feces|Gastrointestinal Tract, Feces|Stool|stool	The material discharged from the bowel during defecation.  It consists of undigested food, intestinal mucus, epithelial cells, and bacteria.
C13235	Fetus	Embryologic_Structure_or_System	Fetus|fetus	(FEET-us) The developing offspring from 7 to 8 weeks after conception until birth.
C13236	Body_Fluid_or_Substance	Anatomic_Structure_System_or_Substance	Body Fluid or Substance|Body Fluids and Substances|Body Fluids or Substances|Fluids|fluids	Liquid and semi liquid substances produced by living organisms to fulfill specific functions or excreted as waste; does not include hormones or enzymes.
C13238	Golgi_Apparatus	Membranous_Cytoplasmic_Organelle	Golgi Apparatus|Golgi|Golgi Complex	A stack of flattened vesicles located between the nucleus and the secretory pole or surface of a cell. Functions in posttranslational processing and sorting of proteins, receiving them from the rough endoplasmic reticulum and directing them to secretory vesicles, lysosomes, or the cell membrane. The movement of proteins takes place by transfer vesicles that bud off from the rough endoplasmic reticulum or golgi apparatus and fuse with the golgi, lysosomes or cell membrane.
C13239	Haptens	Epitopes	Haptens	Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot
C13241	Heterochromatin	Chromatin	Heterochromatin	regions of the genome that are permanently in a highly condensed condition and are not genetically expressed.
C13242	Immunoglobulin_Constant_Region	Immunoglobulin_Domain	Immunoglobulin Constant Region
C13243	Immunoglobulin_Joining_Region	Immunoglobulin_Domain	Immunoglobulin Joining Region
C13244	Immunoglobulin_Switch_Region	Gene_Structure	Immunoglobulin Switch Region	A site on a segment of a B-cell immunoglobulin heavy-chain gene where recombination (or rearrangement) can occur. It is involved in isotype or allotype switching and maturation of the immune response. Ig switch regions are found on genes encoding all five immunoglobulin heavy chains.
C13245	Immunoglobulin_Variable_Region	Immunoglobulin_Domain	Immunoglobulin Variable Region
C13246	Fab_Fragment	Immunoglobulin_Domain	Fab Fragment|Antigen Binding Fragment|Fab|Immunoglobulin, F(ab) Fragment	Part of an immunoglobulin antibody that binds a specific antigen and consists of both a light chain and part of a heavy chain.  By comparison, natural antibodies consist of two heavy and two light chains.  An FAB (fragment antibody) offers the advantages of smaller size and lower cross-reactivity compared to the complete antibody. (NCI04)
C13247	Immunoglobulin_Fc	Immunoglobulin_Domain	Immunoglobulin Fc|Fc Fragment
C13248	Intermediate_Filament	Filament	Intermediate Filament	A class of tough protein filaments (including keratin filaments, neurofilaments, desmin, and vimentin) that measure 8-10 nm in thickness and comprise part of the cytoskeleton of the cytoplasm of most eukaryotic cells; so named because they are intermediate in thickness between actin filaments and microtubules.
C13249	Intron	Gene_Structure	Intron|Intervening Sequence	Non-coding, intervening sequences of DNA that are transcribed, but are removed from within the primary gene transcript and rapidly degraded during maturation of messenger RNA. Most genes in the nuclei of eukaryotes contain introns, as do mitochondrial and chloroplast genes.
C13250	Glomerulus	Kidney_Part	Glomerulus|Malpighian Tuft|Renal Glomerulus
C13251	Long_Terminal_Repeat	Repetitive_Sequence	Long Terminal Repeat|LTR	Identical DNA sequences found at either end of retrovirus proviral DNA, formed by reverse transcription of viral RNA.
C13252	Lymph	Body_Fluid_or_Substance	Lymph|Reticuloendothelial System, Lymph|lymph|lymphatic fluid	(limf) The almost colorless fluid that travels through the lymphatic system and carries cells that help fight infection and disease.
C13253	Lysosome	Membranous_Cytoplasmic_Organelle	Lysosome|lysosome	A class of morphologically heterogeneous cytoplasmic membrane-bound vesicle in animal and plant tissues characterized by their content of a wide variety of glycoprotein hydrolytic enzymes active at an acid pH and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture serves to digest exogenous material, such as bacteria, as well as effete organelles of the cells and is supposed to be under metabolic (hormonal) control.
C13254	Peroxisome	Membranous_Cytoplasmic_Organelle	Peroxisome|Microbody	Subcellular respiratory organelles containing catalase and hydrogen peroxide-producing flavin oxidases among its enzymatic constituents, which carry out an essentially oxidative type of metabolism
C13255	Actin_Filament	Filament	Actin Filament|Microfilament	The finest filamentous element of the cytoskeleton, having a diameter of about 5 nm and consisting primarily of actin.
C13256	Microtubule	Cell_Part	Microtubule|Micro Tubule|Micro-tubule	A cylindrical cytoplasmic element, 20 to 27 nm in diameter and of variable length, that occurs widely in the cytoskeleton of plant and animal cells; microtubules increase in number during mitosis and meiosis, where they may be related to movement of the chromosomes or chromatids on the nuclear spindle during nuclear division.
C13257	Breast_Milk	Breast_Fluid_or_Secretion	Breast Milk|Mammary Gland Milk|Milk	Milk produced by female humans for the purpose of feeding their young.
C13258	Mitochondrion	Membranous_Cytoplasmic_Organelle	Mitochondrion|Mitochondria|mitochondria	Parts of a cell where aerobic production (also called cell respiration) takes place.
C13259	Mucus	Exocrine_Gland_Fluid_or_Secretion	Mucus|mucus	A thick, slippery fluid produced by the membranes that line certain organs of the body, including the nose, mouth, throat, and vagina.
C13260	Mullerian_Duct	Duct	Mullerian Duct|Paramesonephric Duct
C13261	Myelin_Sheath	Nerve_Sheaths	Myelin Sheath|Myelin	fatty, axon-enwrapping sheath that serves to speed up neural conduction, formed by concentric layers of Schwann's cell (peripheral) or oligodendrocyte (CNS) membranes; loss or damage leads to severe loss of neural function, as in multiple sclerosis.
C13262	Heart_Muscle	Retired_Concepts	Heart Muscle|Cardiac Muscle
C13263	Neurofilament	Intermediate_Filament	Neurofilament	intermediate filaments of neurons which add rigidity, tensile strength, and possibly intracellular transport guidance to axons and dendrites.
C13264	Nuclear_Matrix	Nuclear_Structure	Nuclear Matrix	A fibrogranular network of residual structural elements within which are immersed both chromatin and ribonucleoproteins. It appears to extend throughout the nuclear interior from the nucleolus to the nuclear pore complexes along the nuclear periphery.
C13265	Nuclear_Membrane	Cellular_Membrane	Nuclear Membrane|Nuclear Envelope	The nuclear envelope is the double-layer membrane structure enclosing the nucleus in eukaryotic cells. It separates the DNA of the cell from the cytosol. For exchange of material, for example, proteins and mRNA, it is punctured with numerous nuclear pores. (from Wikipedia and NCI)
C13266	Nuclear_Pore	Cell_Part	Nuclear Pore	An octagonal opening, about 70 nm across, where the inner and outer membranes of the nuclear envelope are continuous.
C13267	Nucleolar_Organizer_Region	Chromosome_Structure	Nucleolar Organizer Region	Nucleolar organizer regions (NORs), which are loops of DNA containing ribosomal RNA genes, have been shown to correlate with cell proliferation and malignant transformation.
C13268	Nucleosome	Cell_Part	Nucleosome	The repeating structural units of chromatin, each consisting of approximately 200 base pairs of DNA wound around a protein core. This core is composed of the histones H2A, H2B, H3, and H4.
C13269	Cytoplasmic_Organelle	Cell_Part	Cytoplasmic Organelle|Organelle	Cell part which consists of macromolecules aggregated into discrete structures in the protoplasm. (Digital Anatomist Foundational Model)
C13270	Pancreatic_Secretion	Gastrointestinal_Fluid_or_Secretion	Pancreatic Secretion|Pancreatic Juices|pancreatic juices	Fluids made by the pancreas. Pancreatic juices contain proteins called enzymes that aid in digestion.
C13271	t_9_22_q34_q11	Chromosomal_Translocation	t(9;22)(q34;q11)	An abnormality of chromosome 22 in which part of chromosome 9 is transferred to it.  Bone marrow cells that contain the Philadelphia chromosome are often found in chronic myelogenous leukemia.
C13272	Placenta	Extraembryonic_Structure	Placenta|placenta	The organ that nourishes the developing fetus in the uterus.
C13273	Lung_Surfactant	Respiratory_System_Fluid_or_Secretion	Lung Surfactant|Surfactant|Surfactant, Lung	Pulmonary surfactant lines the lung epithelium and lowers surface tension to prevent collapse at end-expiration. Deficiency of pulmonary surfactant results in respiratory distress syndrome (RDS) in premature infants. Lung surfactant is synthesized in alveolar type II cells, stored in lamellar bodies and secreted via exocytosis.
C13274	Ribosome	Nonmembranous_Cytoplasmic_Organelle	Ribosome	A granule of ribonucleoprotein, 120 to 150 A in diameter, is the site of protein synthesis from aminoacyl-tRNAs as directed by mRNAs.
C13275	Saliva	Exocrine_Gland_Fluid_or_Secretion	Saliva|Head and Neck, Saliva|saliva	(suh-LIE-vuh) The watery fluid made by mucous glands in the mouth. It moistens food to aid in digestion.
C13276	Sebum	Skin_Fluid_or_Secretion	Sebum|sebum	(SEE-bum) An oily substance produced by certain glands in the skin.
C13277	Semen	Male_Genital_System_Fluid_or_Secretion	Semen|semen	Fluid from the prostate and other sex glands that helps transport sperm out of the man's body during orgasm.  Seminal fluid contains sugar as an energy source for sperm.
C13278	Sputum	Body_Fluid_or_Substance	Sputum|sputum	Material containing mucus, cellular debris, microorganisms and sometimes blood or pus.  It is ejected through the mouth from the lungs, bronchi, and trachea.
C13280	Sweat	Skin_Fluid_or_Secretion	Sweat	The liquid secreted by the sweat glands, having a salty taste and a pH that varies from 4.5 to 7.5. Sweat produced by the eccrine sweat glands is clear with a faint characteristic odor, and contains water, sodium chloride, and traces of albumin, urea, and other compounds. Its composition varies with many factors, e.g., fluid intake, external temperature and humidity, and some hormonal activity. Sweat produced by the larger, deeper, apocrine sweat glands of the axillae contains, in addition, organic material which on bacterial decomposition produces an offensive odor.
C13281	Synapse	Cell_Junction	Synapse	A connection between excitable cells, by which an excitation is conveyed from one to the other. (On-line Medical Dictionary)
C13282	Subcellular_Structure	Cell_Structure	Subcellular Structure|Intracellular Structure	Used with tissues and cells (including neoplasms) and microorganisms for microanatomic structures, generally below the size visible by light microscopy.
C13283	Urine	Body_Fluid_or_Substance	Urine|Urinary System, Urine|urine	(YOO-rin) Fluid containing water and waste products. Urine is made by the kidneys, stored in the bladder, and leaves the body through the urethra.
C13284	Vacuole	Membranous_Cytoplasmic_Organelle	Vacuole	membrane-enclosed spherules that serve as subcellular packaging for nutrients, waste, or secretory compounds, or as vehicles to and from the cell membrane; do not use for artificial lipid vesicles (see MEMBRANE MODEL).
C13285	Chromosome_X	Human_Chromosome	Chromosome X
C13286	Chromosome_Y	Human_Chromosome	Chromosome Y	The male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in man and in some other male-heterogametic species in which the homologue of the X chromosome has been retained.
C13287	Z-DNA	DNA_Structure	Z-DNA|zDNA	"zigzag" left-handed conformer of DNA; naturally occurring Z DNA is sensitive to a different set of enzymes and binding proteins than "normal" B DNA, and is thought to play an important role in genetic regulation.
C13288	RGD_Motif	Protein_Binding_Domain	RGD Motif|Arginine-Glycine-Aspartic Acid Cell Adhesion Domain|RGD|RGD Cell Adhesion Domain|RGD Domain|RGD Peptide|RGD Tripeptide Sequence	A consensus tripeptide that is recognized by and for binding to proteins of the integrin family, including many cell adhesion molecules. The one-letter codes for arginine - glycine - aspartic acid.
C13289	Euchromatin	Chromatin	Euchromatin	Euchromatin. The parts of chromosomes that, during interphase, are uncoiled dispersed threads and not stained by ordinary dyes; metabolically active, in contrast to the inert heterochromatin.
C13290	Kringle_Domain	Protein_Binding_Domain	Kringle Domain|Kringle	Kringles are autonomous structural domains, found throughout the blood clotting and fibrinolytic proteins. Kringle domains are believed to play a role in binding mediators (e.g., membranes, other proteins or phospholipids), and in the regulation of proteolytic activity. Kringle domains are characterised by a triple loop, 3-disulphide bridge structure, whose conformation is defined by a number of hydrogen bonds and small pieces of anti-parallel beta-sheet. They are found in a varying number of copies, in some serine proteases and plasma proteins. (pfam.wustl.edu/cgi-bin/getdesc?name=kringle)
C13291	Leucine_Zipper	Protein_Binding_Domain	Leucine Zipper	Domains in DNA-binding proteins that contain amino acid sequences that show periodic arrays of leucine residues. These residues exist in an alpha-helical conformation, with the leucine side chains extending from one alpha helix interdigitating with those displayed from a similar alpha helix of a second polypeptide, facilitating dimerization.
C13292	Open_Reading_Frame	DNA_Sequence	Open Reading Frame|ORF	A reading frame in a sequence of nucleotides in DNA that contains no termination codons and so can potentially translate as a polypeptide chain. (On-line Medical Dictionary)
C13293	TATA_Box	DNA_Sequence	TATA Box	A consensus sequence found in the promoter region of most genes transcribed by eukaryotic RNA polymerase II. It is found about 25 nucleotides before the site of initiation of transcription and has the consensus sequence: 5' TATAAAA 3'. This sequence seems to be important in determining accurately the position at which transcription is initiated. (On-line Medical Dictionary)
C13294	C2H2_Zinc_Finger	Zinc_Finger_Domain	C2H2 Zinc Finger	One of three structural motifs observed in DNA binding domains of zinc proteins. Domains in DNA- and RNA-binding proteins that contain amino acids which are folded into a single structural unit around a zinc atom that links two cysteines and two histidines. Each finger is postulated to recognize a specific sequence of about five nucleotide pairs. Originally identified in the TFIIIA transcription factor, it is also known as the C2H2 zinc finger.
C13295	Telomere	Chromosome_Structure	Telomere|Telomeres	The terminal end of a chromosome arm which has a specialized structure and which is involved in chromosomal replication and stability. Its length is believed to be a few hundred base pairs. Telomeres undergo dramatic changes during the progression of cancer.
C13296	Enhancer	Regulatory_Element	Enhancer	A 50-150bp DNA sequence that increases the rate of transcription of coding sequences. It may be located at various distances and in either orientation upstream from, downstream from or within a structural gene.  When bound by a specific transcription factor it increases the levels of expression of the gene, but is not sufficient alone to cause expression. Distinguished from a promoter, that is alone sufficient to cause expression of the gene when bound.
C13297	Promoter	Regulatory_Element	Promoter	A DNA sequence at which RNA polymerase binds and initiates transcription.
C13298	Repetitive_Sequence	DNA_Sequence	Repetitive Sequence|Repetitive Element	Nucleotide sequences present in multiple copies in the genome. There are several types of repeated sequences. Interspersed (or dispersed) DNA repeats (Interspersed Repetitive Sequences) are copies of transposable elements interspersed throughout the genome.  Flanking (or terminal) repeats (Terminal Repeat Sequences) are sequences that are repeated on both ends of a sequence, for example, the long terminal repeats (LTRs) on retroviruses. Direct terminal repeats are in the same direction and inverted terminal repeats are opposite to each other in direction. Tandem repeats (Tandem Repeat Sequences) are repeated copies which lie adjacent to each other. These can also be direct or inverted. The ribosomal RNA and transfer RNA genes belong to the class of middle repetitive DNA.
C13299	DNA_Sequence	Nucleotide_Sequence	DNA Sequence|Sequence|Sequences	The sequence of nucleotide residues along a DNA chain.
C13300	Umbilical_Cord_Blood	Embryonic_Fluid	Umbilical Cord Blood|umbilical cord blood	Blood from the placenta (afterbirth) that contains high concentrations of stem cells needed to produce new blood cells.
C13301	Mesenchyme	Embryonic_Connective_Tissue	Mesenchyme	Embryonic tissue of mesodermal origin.  Develops into connective tissue, blood vessels, and lymphatic tissue.
C13302	Secondary_Protein_Structure	Protein_Structure	Secondary Protein Structure
C13303	Protein_Structure	Macromolecular_Structure	Protein Structure	The amino acids and their 3-D arrangement in constituting a protein.
C13304	Pulmonary	Anatomy_Modifier	Pulmonary|PULM|pulmonary	Relating to the lungs.
C13305	Laryngeal	Anatomy_Modifier	Laryngeal|laryngeal	(lair-IN-jee-al) Having to do with the larynx.
C13306	Cardiac	Anatomy_Modifier	Cardiac|cardiac	Having to do with the heart.
C13307	Gastric	Anatomy_Modifier	Gastric|gastric	(GAS-trik) Having to do with the stomach.
C13308	Hepatic	Anatomy_Modifier	Hepatic|HEP|hepatic	Pertaining to, affecting, or associated with the liver.
C13309	Vaginal	Anatomy_Modifier	Vaginal|VAG|vaginal	Having to do with the vagina (the birth canal).
C13310	Systemic	General_Modifier	Systemic|SYS|systemic	(sis-TEM-ik) Affecting the entire body.
C13311	Vascular	General_Modifier	Vascular|VASC	Relating to or containing blood vessels.
C13312	Gap_Junction	Epithelial_Cell_Junction	Gap Junction|Communicating Junction|Low-resistance Junction|Nexus|Nexus Junction	Connections between cells which allow passage of small molecules and electric current. Gap junctions were first described anatomically as regions of close apposition between cells with a narrow (1-2 nm) gap between cell membranes. The variety in the properties of gap junctions is reflected in the number of connexins, the family of proteins which form the junctions.
C13313	Helix-Loop-Helix_Domain	DNA_Binding_Domain	Helix-Loop-Helix Domain|HLH Motif	In transcription regulators of cell cycle control, cell determination, and cell differentiation, the conserved HLH (Helix-Loop-Helix) Domain of 40-50 amino acids forms amphipathic helixes between a variable loop. HLHs typically mediate homo- or heterodimerization through interactions with self or other motifs to activate or inactivate trans-activating function. The N-helix often contains DNA-interacting basic residues; the C-helix typically contains characteristically spaced hydrophobic residues. An adjacent basic region of 15 amino acids in most HLH proteins binds to DNA. Basic (b)HLH proteins bind variants of the 'CANNTG' E-box. Proteins lacking the basic domain act as inhibitors, failing to bind DNA. bHLH proteins exhibit specific dimerization partner combinations. In calcium-binding proteins, certain invariant hydrophilic loop residues in the HLH motif bind calcium. (NCI)
C13314	Proteasome	Subcellular_Structure	Proteasome|Proteosome	Proteolytic complexes, proteolytic core of the proteasome system, that degrade cytosolic and nuclear proteins are implicated in ATP dependent ubiquitin protein complex degradation and in antigen processing in antigen presenting cells. The 20S proteasome (700 kD), essential in ATP ubiquitin degradation pathway, has 13-15 subunits each of which has three or four different peptidase activities. The 20S proteasome interacts with additional subunits, PA700 and PA28, to form an ATP-dependent multicatalytic proteinase complex (MPC) involved in the degradation of ubiquitinated cellular proteins and certain non-ubiquitinated proteins. 26S proteasomes may be formed in an ATP dependent fashion from a 20S proteasome and additional components, CF1 (660 kD), CF2 (250 kD) and CF3 (600 kD).
C13315	Epithelial	Anatomy_Modifier	Epithelial|epithelial	(ep-ih-THEE-lee-ul) Refers to the cells that line the internal and external surfaces of the body.
C13316	Cutaneous	Anatomy_Modifier	Cutaneous|cutaneous	(kyoo-TAY-nee-us) Having to do with the skin.
C13317	Hair_Follicle	Hair_Part	Hair Follicle|Follicles|Hair Follicles|follicle|hair follicles	(FOL-i-kul) A sac or pouch-like cavity.
C13318	Transitional_Epithelium	Stratified_Epithelium	Transitional Epithelium	Stratified epithelium that changes shape from cuboidal to squamous when stretched without losing strength or consistency. This type of epithelium is found in the urinary tract.
C13319	Gland	Organ	Gland|gland	An organ that makes one or more substances, such as hormones, digestive juices, sweat, tears, saliva, or milk. Endocrine glands release the substances directly into the bloodstream. Exocrine glands release the substances into a duct or opening to the inside or outside of the body.
C13320	Nose_Nasal_Passages	Retired_Concepts	Nose, Nasal Passages|Respiratory System, Nose, Nasal Passages
C13321	Gastrointestinal_Fluid_or_Secretion	Body_Fluid_or_Substance	Gastrointestinal Fluid or Secretion|Gastrointestinal Fluids and Secretions	Fluids and secretions within the passage leading from the mouth to the anus through the pharynx, esophagus, stomach, and intestine which cause digestion.
C13322	Endometrial	Anatomy_Modifier	Endometrial|endometrial	Having to do with the endometrium (the layer of tissue that lines the uterus).
C13323	Vitreous_Humor	Body_Fluid_or_Substance	Vitreous Humor	A clear, avascular, gelatinous body that occupies the posterior chamber of the eye.  It is bounded by the retina except anteriorly where it lies adjacent to the lens and iris.
C13324	Hematopoietic	Anatomy_Modifier	Hematopoietic|HEMP	Pertaining to or related to the formation of blood cells.
C13325	Serum	Body_Fluid_or_Substance	Serum|serum	The clear liquid part of the blood that remains after blood cells and clotting proteins have been removed.
C13326	Metaphase_Plate	Nuclear_Structure	Metaphase Plate	The plane of the spindle approximately equidistant from the two poles along which the chromosomes are lined up during mitosis or meiosis.
C13327	Hemidesmosome	Anchoring_Junction	Hemidesmosome	Half desmosomes that occur on the basal surface of the stratum basalis of stratified squamous epithelium.
C13328	Caveola	Cell_Part	Caveola|Caveolae	A small pocket, vesicle, cave, or recess communicating with the outside of a cell and extending inward, indenting the cytoplasm and the cell membrane. Such caveolae may be pinched off to form free vesicles within the cytoplasm. They are considered to be sites of uptake of materials into the cell, expulsion of materials from the cell, or sites of addition or removal of cell (unit) membrane to or from the cell surface. (On-line Medical Dictionary)
C13329	Rough_Endoplasmic_Reticulum	Endoplasmic_Reticulum	Rough Endoplasmic Reticulum|Ergastoplasm|Granular Endoplasmic Reticulum|Rough ER|Rough-Surfaced Endoplasmic Reticulum|rER	Membrane organelle of eukaryotes that forms sheets and tubules. Contains the receptor for the signal receptor particle and binds ribosomes engaged in translating mRNA for secreted proteins and the majority of transmembrane proteins. Also a site of membrane lipid synthesis. The membrane is very similar to the nuclear outer membrane. The lumen contains a number of proteins that possess the C terminal signal KDEL. (On-line Medical Dictionary)
C13330	Outer_Mitochondrial_Membrane	Mitochondrial_Membrane	Outer Mitochondrial Membrane|Mitochondrial Outer Membrane	The mitochondrial outer membrane contains the multi-subunit machinery responsible for the specific recognition and translocation of precursor proteins.
C13331	Inner_Mitochondrial_Membrane	Mitochondrial_Membrane	Inner Mitochondrial Membrane|Mitochondrial Inner Membrane	The inner mitochondrial membrane encloses a fluid-filled matrix and is elaborately folded with shelf-like cristae projecting into the matrix. The components of electron transport chain are integral part of the inner membrane.
C13332	Bilateral	Anatomy_Modifier	Bilateral|bilateral	Affecting both the right and left sides of the body.
C13333	Tight_Junction	Epithelial_Cell_Junction	Tight Junction|Occluding Junction|Zonula Occludens	Found near the apical surface of cells in simple epithelia. Forms a sealing "gasket" around the cell by the fusion of adjacent cell membranes which encircle the apical cell surface like a belt or fence. Prevents fluid moving through the intercellular gap and the lateral diffusion of intrinsic membrane proteins between apical and basolateral domains of the plasma membrane as well as occludes the movement of solute molecules between cells. Various proteins components of this junction have been identified, but how they are linked to form the ultrastructure of the junction is not known.
C13334	Minisatellite_Repeats	Repetitive_Sequence	Minisatellite Repeat|Minisatellite|Minisatellite Repeats|Minisatellites|VNTR|Variable Number of Tandem Repeats	Tandem arrays of moderately repetitive (5-50 repeats) short (10-60 bases) DNA sequences found dispersed throughout the genome and clustered near telomeres.  Their degree of repetition is two to several hundred at each locus.  Loci number in the thousands but each locus shows a distinctive repeat unit.  Minisatellite repeats are often called variable number of tandem repeats.
C13335	Origin_of_Replication	Chromosome_Structure	Origin of Replication|ARS|Autonomously Replicating Sequence|ORI|Replication Origin	A DNA sequence necessary and sufficient for initiation of DNA replication.
C13336	PA700_Regulatory_Module	Subcellular_Structure	PA700 Regulatory Module|PA700 Protein|PA700 Protein Complex	Ubiquitinated proteins are degraded by a 26S ATP-dependent protease complex, composed of a 20S catalytic proteasome and two 19S PA700 regulatory modules.  The multi-subunit PA700 complex binds two sites of the 20S proteasome and is composed of at least six related ATPases and approximately fifteen non-ATPase polypeptides.  Each of the ATPases, PSMC1-6, contains an AAA (ATPases associated with diverse cellular activities) domain.  A protein complex containing p42 and p50 enhances PA700 activation of the proteasome.
C13337	Germinal_Center	Lymph_Node_Part	Germinal Center
C13338	Microsatellite_Repeats	Repetitive_Sequence	Microsatellite Repeat|Microsatellite|Microsatellite Repeats|Microsatellites	A variety of simple di- , tri- , tetra-, and pentanucleotide tandem repeats that are dispersed in the euchromatic arms of most chromosomes. The dinucleotide repeat of (GT/CA)n is the most common of these dispersed repeats.
C13339	SH2_Domain	Protein_Binding_Domain	SH2 Domain	A region of protein sequence similarity among members of the SRC family of cytoplasmic tyrosine kinases, and other proteins. The SH2 domain usually mediates binding to phosphotyrosine and neighboring residues of target proteins.
C13340	SH3_Domain	Protein_Binding_Domain	SH3 Domain|SRC Homology Region 3 Domain	A region of protein sequence similarity among members of the SRC family of cytoplasmic tyrosine kinases, and other proteins. The SH3 domain is a protein-binding domain that interacts with cytoskeletal proteins.
C13341	Helix-Turn-Helix_Motif	DNA_Binding_Domain	Helix-Turn-Helix Motif|HTH DNA Binding Domain|Helix-Turn-Helix	The first DNA-binding protein motif to be recognized. Originally identified in bacterial proteins and found in many DNA-binding proteins from both eukaryotes and prokaryotes. They are constructed from two alpha helices connected by a short extended chain of amino acids, which constitute the "turn." The two helices are held at a fixed angle, primarily through interactions between the two helices.
C13342	Immunoglobulin_Hypervariable_Region	Immunoglobulin_Domain	Immunoglobulin Hypervariable Region|CDR|Complimentarity Determining Region|Hypervariable Loop	Within the variable domain of an antibody molecule are three regions called hypervariable regions, areas of high sequence diversity.  These regions form the surfaces that are responsible for antigen binding interactions.  Also known as complementarity determining region or hypervariable loop.
C13343	Immunoglobulin_Hinge_Region	Immunoglobulin_Domain	Immunoglobulin Hinge Region	A region of relative flexibility between the variable and constant regions of an antibody molecule.
C13344	Topical	Anatomy_Modifier	Topical|topical	On the surface of the body.
C13345	Stoma	Surgically_Created_Structure	Stoma|stoma	(STO-ma) A surgically created opening from an area inside the body to the outside.
C13346	Intravenous	Anatomy_Modifier	Intravenous|IV|intravenous	(in-tra-VEE-nus) IV. Within a blood vessel.
C13347	Aspirate	Other_Anatomic_Concept	Aspirate|ASPR|aspirate	(AS-pi-rit) Fluid withdrawn from a lump, often a cyst, or a nipple.
C13348	Genital	Anatomy_Modifier	Genital	The group of organs and glands involved with having a child. In women, these are the uterus (womb), the fallopian tubes, the ovaries, and the vagina (birth canal). The reproductive system in men includes the testes, the prostate, and the penis.
C13349	Myeloid	Anatomy_Modifier	Myeloid|myeloid	(MYE-eh-loyd) Pertaining to, derived from, or manifesting certain features of the bone marrow. In some cases also pertains to certain types of non-lymphocyte white blood cells found in the bone marrow, including granulocyte, monocyte, and platelet lineages. Also called myelogenous.
C13350	Lymphocytic	Anatomy_Modifier	Lymphocytic|LYMCT|lymphocytic	(lim-fo-SIT-ik) Referring to lymphocytes, a type of white blood cell.
C13351	Axillary	Anatomy_Modifier	Axillary|AX|axillary	(AK-sil-air-ee) Pertaining to the armpit area, including the lymph nodes that are located there.
C13352	Intraperitoneal	Anatomy_Modifier	Intraperitoneal|IP|IPA|intraperitoneal	(IN-tra-per-ih-toe-NEE-al) IP.  Within the peritoneal cavity (the area that contains the abdominal organs).
C13353	Subcutaneous	Anatomy_Modifier	Subcutaneous|SQ|subcutaneous	Beneath the skin.
C13354	Brain_Ventricle	Retired_Concepts	Brain Ventricle|Ventricles|Ventricles, Brain
C13355	Chromosome_Arm	Chromosome_Structure	Chromosome Arm	Under the microscope chromosomes appear as thin, thread-like structures. They all have a short arm and long arm separated by a primary constriction called the centromere. The short arm is designated as p and the long arm as q.(NCI)
C13356	Plasma	Body_Fluid_or_Substance	Plasma|plasma	(PLAS-ma) The clear, yellowish, fluid part of the blood that carries the blood cells. The proteins that form blood clots are in plasma.
C13359	Gastrointestinal	Anatomy_Modifier	Gastrointestinal|GI|gastrointestinal	(GAS-tro-in-TES-tih-nul) GI.  Refers to the stomach and intestines.
C13360	Thoracic	Anatomy_Modifier	Thoracic|thoracic	(thor-ASS-ik) Having to do with the chest.
C13361	Nuclear	Anatomy_Modifier	Nuclear|NUC	Pertaining to the nucleus.
C13362	Cardiopulmonary	Anatomy_Modifier	Cardiopulmonary|cardiopulmonary	Having to do with the heart and lungs.
C13363	Colorectal	Anatomy_Modifier	Colorectal|Colon or Rectum|colorectal	(ko-lo-REK-tul) Having to do with the colon or the rectum.
C13364	Autocrine_Systems	Other_Anatomic_Concept	Autocrine Systems|Autocrine	Organ systems involved in self-stimulation through cellular production of a factor and a specific receptor for it.
C13365	Spindle_Pole_Body	Subcellular_Structure	Spindle Pole Body	The spindle pole body (SPB) is the microtubule organizing center (MTOC) in the yeast Saccharomyces that plays a pivotal role in such diverse processes as mitosis, budding, and mating. (from Cell. 1997;89:1077-86)
C13366	Coated_Pit	Cell_Part	Coated Pit	Specialized depressions on the cell surface involved in receptor-mediated endocytosis; the visible proteinaceous layer on the cytosolic side of the depression provides the coated appearance.
C13367	Homeo_Domain	Helix-Turn-Helix_Motif	Homeo Domain|Homeodomain	The DNA-binding homeo domain was originally identified in transcription factor proteins encoded by homeobox genes (homeotic genes).  The homeo domain is structurally similar to the helix-turn-helix DNA-binding domain of CRO and Lambda repressor.
C13368	Keratin_Filament	Intermediate_Filament	Keratin Filament	A class of intermediate filaments that form a network within epithelial cells and anchor to desmosomes, thus imparting tensile strength to the tissue
C13369	Alpha_Helix	Secondary_Protein_Structure	Alpha Helix	A right-handed spiral conformation; the a-helix has a pitch of 5.4 A and has 3.6 amino acid residues per turn; every main chain C=O and N-H group is hydrogen-bonded to a peptide bond 4 residues away; the peptide planes are roughly parallel with the helix axis and the dipoles within the helix are aligned, i.e. all C=O groups point in the same direction and all N-H groups point the other way; side chains point outward from helix axis and are generally oriented towards its amino-terminal end.  (from expasy.org)
C13370	Cis-Acting_Sequence	DNA_Sequence	Cis-Acting Sequence|Cis-Acting Locus	Cis-acting locus is a section of DNA that affects the activity of DNA sequences on that same molecule of DNA.
C13371	_5_Untranslated_Region	Gene_Structure	5' Untranslated Region	Sequences on the 5' end of messenger RNAs that are not translated into protein.  5'UTR extends from the transcription start site to just before the ATG translation initiation codon.  This region contains the ribosome binding site and other transcription and translation regulating sequences.
C13372	Response_Elements	Regulatory_Element	Response Elements	Nucleotide sequences, usually upstream, which are recognized by specific regulatory transcription factors, thereby causing gene response to various regulatory agents. These elements may be found in both promotor and enhancer regions.
C13373	_3_Untranslated_Region	Gene_Structure	3' Untranslated Region	Sequences on the 3' end of messenger RNAs that are not translated into protein. The 3'UTR is involved in many post-transcriptional regulatory pathways, including regulating translation efficiency, mRNA stability, and polyadenylation signals.
C13374	Intracisternal_A-Particle	Repetitive_Sequence	Intracisternal A-Particle|IAP	Retroviral-like intracisternal A particles.  High copy number family of repeated elements in the mouse with a typical proviral organization.  Expressed very early in mouse development (2-8 cell stage) and in transformed cells.  Mutant alleles of various genes contain newly-integrated IAP genes.
C13375	Chromosome_Fragile_Site	Chromosome_Structure	Chromosome Fragile Site|Fragile Site	Heritable sensitive regions of chromosomes which show up in vitro as non-staining bands. They are associated with chromosome breakage and other aberrations. No abnormal phenotype has been definitely identified with autosomal fragile sites, but some rare autosomal recessive disorders may be due to homozygosity for fragile sites. A fragile site on the X chromosome is associated with Fragile X Syndrome. Fragile sites are designated by the letters "fra" followed by the designation for the specific chromosome and locus.
C13376	Cell_Surface_Structure	Retired_Concepts	Cell Surface Structure
C13377	Chromosome_Structure	Nuclear_Structure	Chromosome Structure|Chromosomal Organization|Chromosomal Structure|Chromosome Organization	The 3-D organization of histones and other proteins on chromosomal DNA in the nucleus and allow for its form and function during cellular growth and division.
C13378	Fundus	Other_Anatomic_Concept	Fundus|fundus	The larger part of a hollow organ that is farthest away from the organ's opening. The bladder, gallbladder, stomach, uterus, eye, and cavity of the middle ear all have a fundus.
C13379	Protein_Domain	Protein_Structure	Protein Domain|Protein Feature|Protein Motif|Protein Region	A protein domain is a structurally or functionally defined protein region.
C13380	_5q	Chromosome_Arm	5q|Chromosome 5 Distal Arm|Chromosome 5 Long Arm|Chromosome 5q	Distal (long) arm of chromosome 5
C13381	_8p	Chromosome_Arm	8p|Chromosome 8 Proximal Arm|Chromosome 8 Short Arm|Chromosome 8p	Proximal (short) arm of chromosome 8
C13382	_17p	Chromosome_Arm	17p|Chromosome 17 Proximal Arm|Chromosome 17 Short Arm|Chromosome 17p	Proximal (short) arm of chromosome 17
C13383	_18q	Chromosome_Arm	18q|Chromosome 18 Distal Arm|Chromosome 18 Long Arm|Chromosome 18q	Distal (long) arm of chromosome 18
C13384	_7q	Chromosome_Arm	7q|Chromosome 7 Distal Arm|Chromosome 7 Long Arm|Chromosome 7q	Distal (long) arm of chromosome 7
C13385	_5q31	Chromosome_Band	5q31|Chromosome 5q31	A chromosome band present on 5q
C13386	_7q31	Chromosome_Band	7q31|Chromosome 7q31	A chromosome band present on 7q
C13387	_17p12	Chromosome_Band	17p12|Chromosome 17p12	A chromosome band present on 17p
C13388	_8p22	Chromosome_Band	8p22|Chromosome 8p22	A chromosome band present on 8p
C13389	_11q	Chromosome_Arm	11q|Chromosome 11 Distal Arm|Chromosome 11 Long Arm|Chromosome 11q	Distal (long) arm of chromosome 11
C13390	_11q23	Chromosome_Band	11q23|Chromosome 11q23	A chromosome band present on 11q
C13391	BAT_Locus	Microsatellite_Repeats	BAT Locus|BAT Loci	Microsatellite repeats that have been used as markers of microsatellite instability.  BAT26, a poly(A) tract in MSH2 intron 5, is one example of a BAT locus.  Presence of alterations in the BAT26 locus, detected in stool samples, may be an easy and non-invasive detection method for colorectal cancer.
C13392	_3p	Chromosome_Arm	3p|Chromosome 3 Proximal Arm|Chromosome 3 Short Arm|Chromosome 3p	Proximal (short) arm of chromosome 3
C13393	Lobe	Other_Anatomic_Concept	Lobe|lobe	A portion of an organ, such as the liver, lung, breast, or brain.
C13394	Myelogenous	Anatomy_Modifier	Myelogenous|myelogenous	(mye-eh-LAH-jen-us) Produced by, or originating in, the bone marrow.
C13395	t_8_21_q22_q22	Chromosomal_Translocation	t(8;21)(q22;q22)|Eight-Twenty-One
C13396	Allogeneic_Lymphocyte	Lymphocyte	Allogeneic Lymphocyte|Lymphocytes, Allogeneic	A cell that is antigenically distinct from other lymphocytes.
C13397	B-DNA	DNA_Structure	B-DNA|B-Form DNA|Right-Handed DNA	A duplex of DNA is formed by two complementary chains that are arranged in an anti-parallel manner. B-DNA is about 20 Angstrom in diameter and a right-handed double helix with a wide major groove easily accessible to proteins and narrow minor groove. B-DNA is the most common DNA conformation in vivo and the favored conformation at high water concentrations. Base pairs are nearly perpendicular to the helix axis and sugar pucker is C2'-endo.
C13398	Embryonic_Fluid	Extraembryonic_Structure	Embryonic Fluid|Embryonic Fluids|Embryonic Tissue, Fluids, Secretions	Fluids surrounding or related to an embryo.
C13399	All_Sites	Anatomic_Sites	All Sites	Anything relevant to all anatomic sites - non-specific.
C13400	Anatomic_Sites_Other	Anatomic_Sites	Anatomic Sites, Other
C13401	Breast_Fluid_or_Secretion	Exocrine_Gland_Fluid_or_Secretion	Breast Fluid or Secretion|Breast Fluids and Secretions|Mammary Gland Fluids and Secretions	Any of the secretions of the breast.
C13402	Chromatin_Structure	Macromolecular_Structure	Chromatin Structure	The more readily stainable portion of the cell nucleus, forming a network of nuclear fibrils within the achromatin of a cell. It is a deoxyribonucleic acid attached to a protein (primarily histone) structure base and is the carrier of genes in inheritance. It occurs in two states, euchromatin and heterochromatin, with different staining properties, and during cell division, it coils and folds to form the chromosomes.
C13403	Contractile_System	Subcellular_Structure	Contractile System	Contractile system directs cell movement and is responsible for maintaining or changing cell shape. The system consists of many specialized cytoplasmic proteins, including actin, myosin, tubulin, kinesin, other cytoskeletal and contractile system proteins. (NCI)
C13404	DNA_Structure	Macromolecular_Structure	DNA Structure	It refers to the secondary or tertiary structure of DNA. (NCI)
C13405	Drug_Binding_Site	Ligand_Binding_Domain	Drug Binding Site	The reactive parts of a macromolecule that directly participate in its specific combination with a drug.
C13406	MYC_Box	Protein_Domain	MYC Box	MYC boxes I and II, found in the N termini of all members of the MYC protein family, function to direct the degradation of the c-MYC protein. Both MYC boxes I and II contain sufficient information to independently direct the degradation of otherwise stably expressed proteins to which they are fused. At least part of the MYC box-directed degradation occurs via the proteasome.
C13407	Peptide_Conformation	Miscellaneous_Molecular_Biology_Terms	Peptide Conformation	The 3-D structure of peptides.
C13408	Putative_DNA_Chromatin_Binding_Motif_1	DNA_Binding_Domain	Putative DNA/Chromatin Binding Motif 1|PUT 1	Putative DNA/Chromatin Binding Motif 1 is a protein containing three cysteine-rich zinc-binding PHD/LAP domains, a DNA-binding domain found in the Drosophila dead ringer gene product, five putative nuclear localization signals, and other conserved regions of unknown function.  The protein may be expressed as a 170-kD protein in the nucleus and shares 56% overall amino acid sequence identity with RBBP2, which plays an important role in RB tumor suppressor regulation.  (from OMIM 605393 and NCI)
C13409	Skin_Fluid_or_Secretion	Body_Fluid_or_Substance	Skin Fluid or Secretion|Skin Fluid and Secretion|Skin Fluids and Secretions|Skin-Fluids, Secretions	Secretions of the skin.
C13410	Transmembrane_Domain	Protein_Domain	Transmembrane Domain|TM Domain|Transmembrane Region	The portion of an integral membrane protein crossing through the plasma lemma (cell membrane) or that of an internal vesicle. This region is highly hydrophobic, approximately 20 amino acids long, and bordered by charged amino acids.
C13411	Unspecified_Anatomic_Sites	Anatomic_Sites	Unspecified Anatomic Sites|Unspecified Site	Research that isn't focused on a specific site.
C13412	V3_Loop	Protein_Structure	V3 Loop|V3 Loop of HIV-1	Third hypervariable region (V3) of the gp120 HIV envelope protein.
C13413	Whole_Organism	Anatomy_Modifier	Whole Organism	Considering the organism as a whole
C13415	intravesical	Anatomy_Modifier	Intravesical|INVSC|intravesical	(in-tra-VES-ih-kal) Within the bladder.
C13416	Adrenal_Fluid_or_Secretion	Other_Anatomic_Concept	Adrenal Fluid or Secretion|Adrenal Fluids and Secretions|Adrenal-Fluids, Secretions	Epinephrine and norepinephrine from the medulla and steroid hormones from the cortex.
C13417	Connective_Tissue_Fluid_or_Secretion	Retired_Concepts	Connective Tissue Fluid or Secretion|Connective Tissue Fluids and Secretions|Connective Tissue, Fluids, Secretions	Fluids surrounding connective tissue.
C13418	Head_and_Neck_Fluids_and_Secretions	Other_Anatomic_Concept	Head and Neck Fluids and Secretions|Head and Neck, Fluids, Secretions|Head and Neck-Fluids, Secretions	Secretions and fluids from the area of the body generally construed to comprise base of skull and facial bones, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature and lymph nodes draining these areas.
C13419	Multiple_Cancer_Sites	Multiple_Anatomic_Sites	Multiple Cancer Sites	More than one cancer site.
C13420	Multiple_Anatomic_Sites	Anatomic_Sites	Multiple Anatomic Sites|Multiple Sites, Person	Present at many sites of the body.
C13421	Histone_Fold	Helix-Loop-Helix_Domain|Protein_Binding_Domain	Histone Fold	A protein structural element originally identified in the core histones.  It is of the helix-loop-helix type and is involved in protein-protein interactions via a "handshake" motif with a histone fold partner.  Also involved in protein-DNA interactions.
C13422	HMG_Domain	DNA_Binding_Domain	HMG Domain|HMG Box|High Mobility Group Domain	Each HMG subfamily is a distinct set of proteins with identifiable structural characteristics and a specific type of targets to induce characteristic changes in the structure of its binding site.
C13423	POU_Domain	Helix-Turn-Helix_Motif	POU Domain	The POU domain is a bipartite DNA binding domain recognized originally as a shared structural motif in the Pit-1, Oct-1/Oct-2, and Unc-86 transcription factors (POU).  It is comprised by a C-terminal homeo domain, and an N-terminal POU-specific domain, separated by a non-conserved linker.  The POU-specific domain, like the homeo domain, is folded in a helix-turn-helix motif.
C13424	Winged_Helix	Helix-Turn-Helix_Motif	Winged Helix	The winged helix is a common, 100 amino acid DNA-binding domain which is a variant of the helix-turn-helix motif found in the "forkhead" transcription factor gene family.
C13425	DNA_Binding_Domain	Ligand_Binding_Domain	DNA Binding Domain|Protein Motifs, DNA-Binding	A region of a protein that interacts with DNA. Among the various recognized structural motifs present in DNA binding domains are the helix-loop-helix and the zinc-finger.
C13426	Protein_Binding_Domain	Ligand_Binding_Domain	Protein Binding Domain|Protein Binding Motif|Protein-Protein Interaction Domain	Protein Binding Domains are structural motifs responsible for the peptide/protein binding activity of proteins.
C13427	Zinc-Binding_DNA-Binding_Motif	DNA_Binding_Domain|Metal_Binding_Site	Zinc-Binding, DNA-Binding Motif	Zinc-binding, DNA-binding motifs in proteins contain amino acids that are folded into a single DNA-binding structural unit around a zinc atom.
C13428	Hormone_Receptor_DNA-Binding_Domain	Zinc_Finger_Domain	Hormone Receptor DNA-Binding Domain|C4 Zinc Finger|Zinc Twist Motif	One of three structural motifs observed in DNA binding domains of zinc proteins.  Originally identified in the glucocorticoid receptor, it's also known as the C4 zinc finger, or the zinc twist.  Each of two zinc atoms is bound to four cysteine residues; the zinc twist is represented by a helical DNA recognition site located between the two zinc atoms.
C13429	Zinc_Cluster	Zinc_Finger_Domain	Zinc Cluster|C6 Zinc Cluster	The zinc cluster is one of three structural motifs observed in the DNA-binding domains of zinc proteins.  In the "zinc cluster" two zinc atoms are liganded by six cysteine residues.  Originally identified in the GAL4 transactivator, it is also known as the C6 zinc cluster, binuclear cluster, and the Zn(II)2Cys6 motif.
C13430	Mitotic_Chromosome	Chromosome	Mitotic Chromosome	Condensed chromosomes observed during the M phase of the cell cycle.  Individual chromosomes can be discerned and differentiated morphologically.
C13431	Interphase_Chromosome	Chromosome	Interphase Chromosome	Interphase chromosomes are decondensed chromosomes that reside in the interphase nucleus in the form of chromatin. Two types of chromatin, euchromatin and heterochromatin, can be discerned microscopically.
C13432	Chromosome_Band	Chromosome_Structure	Chromosome Band|Chromosomal Bands	Chromosomal bands observed after staining with specific dyes.  The band pattern is the result of differential interactions between the dye and nonadjacent chromosomal regions.
C13433	Chromatin_Fiber	Higher_Order_Chromatin_Structure	Chromatin Fiber|30 nm Chromatin Fiber|30 nm Fiber	A level of DNA packaging in chromatin above that of the nucleosome, the fundamental subunit of chromatin structure.  The chromatin fiber has a thickness of about 30 nanometers and results from the folding of a linear array of nucleosomes (thickness about 10 nm) into a more compact fiber.
C13434	Higher_Order_Chromatin_Structure	Chromatin_Structure	Higher Order Chromatin Structure|Higher Order Chromatin Folding|Higher Order Structure	Refers to various levels of DNA packaging in the chromosomes above that of the nucleosome.  Includes the chromatin fiber and higher levels of folding such as loops.
C13435	Chromatin_Loop	Higher_Order_Chromatin_Structure	Chromatin Loop|Chromatin Loop Domains|DNA Loop	A higher order chromatin structure above the level of the chromatin fiber.  The organization of chromatin into loops permits the partitioning of chromatin into topologically independent domains, and is thought to facilitate its compartmentation into functionally independent regions.
C13436	Chromosome_Territory	Cell_Part	Chromosome Territory|Chromosomal Territory	The physical volume occupied by a specific chromosome in the interphase nucleus.  The territories from distinct chromosomes do not appear to overlap, preventing an intermingling of the decondensed chromatin.  Relative to a nuclear landmark (e.g. nucleolus), chromosome territories appear to differ from cell to cell.
C13437	Matrix_Attachment_Region	Chromosome_Structure	Matrix Attachment Region|MAR	Regions of chromosomal DNA attached to a structural component of the interphase nucleus termed the nuclear matrix, permitting the partitioning of DNA in the chromosomes into looped chromatin domains.
C13438	Death_Domain	Protein_Binding_Domain	Death Domain	The death domain is a protein region, approximately 80 amino acids long, that is required for transmission of the cytotoxic signal of apoptosis and is present in the TNF receptor, FAS, and several downstream signaling molecules.  Transmission of the apoptotic signal requires the functional interaction of proteins via the death domain.
C13439	TRAF_Domain	Protein_Binding_Domain	TRAF Domain|TNF Receptor-Associated Factor Motif|TRAF Motif	The TRAF domain is the portion of TRAF family adaptor proteins which bind to TNF receptor cytoplasmic domain. It is the C-terminal homology region of 230 amino acids of signal-transducing proteins associated with members of the TNFR superfamily. This domain is involved in a variety of specific protein-protein interactions.
C13440	Breast_and_Ovary	Retired_Concepts	Breast and Ovary
C13441	Short_Tandem_Repeat	Repetitive_Sequence	Short Tandem Repeat|STR|Simple Sequence Repeat	Short tandem repeats are multiple, end-to-end copies of a short DNA sequence usually comprised of di-, tri-, or tetranucleotide repeat units.
C13442	Anatomy_Modifier	Qualifier	Anatomy Qualifier|Anatomy Qualifiers
C13443	Immunoglobulin_Diversity_Region	Immunoglobulin_Domain	Immunoglobulin Diversity Region	Immunoglobulin genes are formed by somatic recombination of multiple gene elements. Light chains use variable (V) and joining (J) elements, whereas heavy chains incorporate an additional diversity (D) element between the V and J elements.
C13444	Bone_and_Cartilage_Funding	Funding_Category	Bone and Cartilage Funding|Bone and Cartilage	Research dollars spent on bone or cartilage research.
C13445	Gene_Structure	Chromosome_Structure	Gene Feature|Gene Organization|Gene Structure|Gene Structure/Organization|Seq Feature|Sequence Feature	Refers to the arrangement of structural elements that comprise a gene or transcription unit, among which are the transcription initiation site, the protein coding sequences, intervening sequences, and the transcription termination or polyadenylation sites.  Also includes the regulatory elements (enhancers, silencers, and the promoter) that lie outside the boundaries of the transcribed unit.
C13446	Nuclear_Structure	Subcellular_Structure	Nuclear Structure	Any structures that are enclosed within nucleus are considered nuclear structure, including any macromolecular structures. (NCI)
C13447	Nonexchangeable_Site	Protein_Structure	Nonexchangeable Site	A binding site where a ligand is permanently bound.
C13448	Microtubule_Bundle	Subcellular_Structure	Microtubule Bundle	It is the aggregated products of microtubules during mitosis where chromosomes line up prior to the segregation process. Many antineoplastic agents cause cytotoxicity by inducing microtubular bundle formation irreversibly. (NCI)
C13449	RNA_Conformation	Miscellaneous_Molecular_Biology_Terms	RNA Conformation	Related to the secondary level of structural organization of RNA.  RNA can be found in various conformations, including double- as well as single-stranded, and in loops.
C13450	bHLH_Domain	Helix-Loop-Helix_Domain	bHLH Domain	The bHLH domain is a bipartite DNA-binding domain containing a basic region upstream of an amphipathic helix-loop-helix region. The basic region interacts with DNA and the HLH motif mediates protein dimerization.
C13451	Pre-Condensed_Chromosomes	Chromosome	Pre-Condensed Chromosomes|Genetics, Pre-Condensed Chromosomes	It refers to the chromosome status during the prophase of mitotic division. (NCI)
C13452	Other_Body_Fluids_and_Secretions	Other_Anatomic_Concept	Other Body Fluids and Secretions|Other Body Fluids, Secretions	Liquid substances produced by living organisms to fulfill specific functions or excreted as waste. Secretions do not include hormones or enzymes.
C13453	Metal_Binding_Site	Ligand_Binding_Domain	Metal Binding Site	The specific parts of a protein molecule that directly participate in its interactions with a metal ion.
C13454	Linear_Sequence_Epitopes	Epitopes	Linear Sequence Epitopes	An epitope composed of adjacent amino acids
C13455	Sister_Chromatid	Chromatid	Sister Chromatid	Sister chromatids are the two newly synthesized daughter chromatids derived from the same chromosome parent.  During chromosomal pairing in meiosis, recombination can occur between sister or non-sister chromatids.
C13456	Bone_Marrow_Stem_Cell	Hematopoietic_Stem_Cell	Bone Marrow Stem Cell|Bone Marrow Stem Cells	Primitive blood cells residing in the bone marrow, derived from embryonic mesenchyme, and capable of differentiating into any of the blood cell line progenitor cells (erythroblasts, young granulocytic series cells, megakaryocytes, etc.)
C13457	Cytoplasmic_Tail	Protein_Domain	Cytoplasmic Tail|Cytoplasmic Domain	The part of a transmembrane protein which projects into the cytoplasm.
C13458	Extracellular_Domain	Protein_Domain	Extracellular Domain|External Domain	The part of a transmembrane protein which projects into the environment surrounding a cell.
C13459	Protease_Domain	Substrate_Domain	Protease Domain|Proteolytic Domain	The portion of a proteolytic protein which causes hydrolysis and cleavage of other protein polypeptides.
C13460	Proximal_Enhancer_Elements	Enhancer	Proximal Enhancer Element|Proximal Enhancer Elements	Enhancer sequences found nearby to the gene it regulates.
C13461	Distal_Enhancer_Elements	Enhancer	Distal Enhancer Elements	Enhancer sequences found at a distance from the gene it regulates.
C13462	Upstream_Enhancer	Enhancer	Upstream Enhancer	An enhancer which is located 5' of the gene it regulates.
C13463	Downstream_Enhancer	Enhancer	Downstream Enhancer	An enhancer which is located 3' of the gene it regulates.
C13464	Vaginal_and_Other_Genital	Anatomy_Modifier	Vaginal and Other Genital
C13465	Bronchial_Secretion	Respiratory_System_Fluid_or_Secretion	Bronchial Secretion
C13466	_20q13	Chromosome_Band	20q13	A chromosome band present on 20q
C13467	_9q34_1	Chromosome_Band	9q34.1	A chromosome band present on 9q
C13468	_1q24-q25	Chromosome_Band	1q24-q25	A chromosome band present on 1q
C13469	_14q32_3	Chromosome_Band	14q32.3	A chromosome band present on 14q
C13470	Xp11_2-p11_4	Chromosome_Band	Xp11.2-p11.4	A chromosome band present on Xp
C13471	_3p21_3	Chromosome_Band	3p21.3	A chromosome band present on 3p
C13472	_2pter-p12	Chromosome_Band	2pter-p12	A chromosome band present on 2p
C13473	_1p21-p13	Chromosome_Band	1p21-p13	A chromosome band present on 1p
C13474	_19q13_1	Chromosome_Band	19q13.1	A chromosome band present on 19q
C13475	_18q21_3	Chromosome_Band	18q21.3	A chromosome band present on 18q
C13476	_19q13_1-q13_2	Chromosome_Band	19q13.1-q13.2	A chromosome band present on 19q
C13477	_22q11	Chromosome_Band	22q11	A chromosome band present on 22q
C13478	_1p32	Chromosome_Band	1p32	A chromosome band present on 1p
C13479	_10p13	Chromosome_Band	10p13	A chromosome band present on 10p
C13480	_7q34	Chromosome_Band	7q34	A chromosome band present on 7q
C13481	_17q21	Chromosome_Band	17q21	A chromosome band present on 17q
C13482	_13q12_3	Chromosome_Band	13q12.3	A chromosome band present on 13q
C13483	_11q23_3	Chromosome_Band	11q23.3	A chromosome band present on 11q
C13484	_11q13	Chromosome_Band	11q13	A chromosome band present on 11q
C13485	_16q22_1	Chromosome_Band	16q22.1	A chromosome band present on 16q
C13486	_12q14	Chromosome_Band	12q14	A chromosome band present on 12q
C13487	_6p21_2	Chromosome_Band	6p21.2	A chromosome band present on 6p
C13488	_11p15_5	Chromosome_Band	11p15.5	A chromosome band present on 11p
C13489	_9p21	Chromosome_Band	9p21	A chromosome band present on 9p
C13490	_14q24_3-q31	Chromosome_Band	14q24.3-q31	A chromosome band present on 14q
C13491	_10p11_2	Chromosome_Band	10p11.2	A chromosome band present on 10p
C13492	_17p13_3	Chromosome_Band	17p13.3	A chromosome band present on 17p
C13493	_5q33-q35	Chromosome_Band	5q33-q35	A chromosome band present on 5q
C13494	_10q11-q12	Chromosome_Band	10q11-q12	A chromosome band present on 10q
C13495	_20q11_2	Chromosome_Band	20q11.2	A chromosome band present on 20q
C13496	_7p12	Chromosome_Band	7p12	A chromosome band present on 7p
C13497	_8q22-q23	Chromosome_Band	8q22-q23	A chromosome band present on 8q
C13498	Xp11_2	Chromosome_Band	Xp11.2	A chromosome band present on Xp
C13499	_12q23	Chromosome_Band	12q23	A chromosome band present on 12q
C13500	_12p12	Chromosome_Band	12p12	A chromosome band present on 12p
C13501	_7q32-q36	Chromosome_Band	7q32-q36	A chromosome band present on 7q
C13502	_3p11_2	Chromosome_Band	3p11.2	A chromosome band present on 3p
C13503	_19p13_1	Chromosome_Band	19p13.1	A chromosome band present on 19p
C13504	_17q21_1	Chromosome_Band	17q21.1	A chromosome band present on 17q
C13505	_12q13	Chromosome_Band	12q13	A chromosome band present on 12q
C13506	_2q33_3-q34	Chromosome_Band	2q33.3-q34	A chromosome band present on 2q
C13507	_21q22_3	Chromosome_Band	21q22.3	A chromosome band present on 21q
C13508	_1q21-q23	Chromosome_Band	1q21-q23	A chromosome band present on 1q
C13509	_12p13	Chromosome_Band	12p13	A chromosome band present on 12p
C13510	_3q24-q28	Chromosome_Band	3q24-q28	A chromosome band present on 3q
C13511	_22q12	Chromosome_Band	22q12	A chromosome band present on 22q
C13512	_4q34-q35	Chromosome_Band	4q34-q35	A chromosome band present on 4q
C13513	_15q26_1	Chromosome_Band	15q26.1	A chromosome band present on 15q
C13514	_11q13_3	Chromosome_Band	11q13.3	A chromosome band present on 11q
C13515	_1p36_2-p36_1	Chromosome_Band	1p36.2-p36.1	A chromosome band present on 1p
C13516	_14q13	Chromosome_Band	14q13	A chromosome band present on 14q
C13517	_11q24_1-q24_3	Chromosome_Band	11q24.1-q24.3	A chromosome band present on 11q
C13518	_13q12	Chromosome_Band	13q12	A chromosome band present on 13q
C13519	_14q24_3	Chromosome_Band	14q24.3	A chromosome band present on 14q
C13520	_2p23-p22	Chromosome_Band	2p23-p22	A chromosome band present on 2p
C13521	_6q21	Chromosome_Band	6q21	A chromosome band present on 6q
C13522	_12q13_2-q13_3	Chromosome_Band	12q13.2-q13.3	A chromosome band present on 12q
C13523	_2q14	Chromosome_Band	2q14	A chromosome band present on 2q
C13524	_7p13	Chromosome_Band	7p13	A chromosome band present on 7p
C13525	_4q21	Chromosome_Band	4q21	A chromosome band present on 4q
C13526	_1p	Chromosome_Arm	1p|Chromosome 1 Proximal Arm|Chromosome 1 Short Arm|Chromosome 1p	Proximal (short) arm of chromosome 1
C13527	_1p36_3	Chromosome_Band	1p36.3	A chromosome band present on 1p
C13528	_1q	Chromosome_Arm	1q|Chromosome 1 Distal Arm|Chromosome 1 Long Arm|Chromosome 1q	Distal (long) arm of chromosome 1
C13529	_11p	Chromosome_Arm	11p|Chromosome 11 Proximal Arm|Chromosome 11 Short Arm	Proximal (short) arm of chromosome 11
C13530	_10p	Chromosome_Arm	10p|Chromosome 10 Proximal Arm|Chromosome 10 Short Arm	Proximal (short) arm of chromosome 10
C13531	_10q	Chromosome_Arm	10q|Chromosome 10 Distal Arm|Chromosome 10 Long Arm	Distal (long) arm of chromosome 10
C13532	_12p	Chromosome_Arm	12p|Chromosome 12 Proximal Arm|Chromosome 12 Short Arm	Proximal (short) arm of chromosome 12
C13533	_12q	Chromosome_Arm	12q|Chromosome 12 Distal Arm|Chromosome 12 Long Arm	Distal (long) arm of chromosome 12
C13534	_13q	Chromosome_Arm	13q|Chromosome 13 Distal Arm|Chromosome 13 Long Arm	Distal (long) arm of chromosome 13
C13535	_13p	Chromosome_Arm	13p|Chromosome 13 Proximal Arm|Chromosome 13 Short Arm	Proximal (short) arm of chromosome 13
C13536	_20q11-q12	Chromosome_Band	20q11-q12	A chromosome band present on 20q
C13537	_14p	Chromosome_Arm	14p|Chromosome 14 Proximal Arm|Chromosome 14 Short Arm|Chromosome 14p	Proximal (short) arm of chromosome 14
C13538	_14q	Chromosome_Arm	14q|Chromosome 14 Distal Arm|Chromosome 14 Long Arm|Chromosome 14q	Distal (long) arm of chromosome 14
C13539	_15q	Chromosome_Arm	15q|Chromosome 15 Distal Arm|Chromosome 15 Long Arm	Distal (long) arm of chromosome 15
C13540	_15p	Chromosome_Arm	15p|Chromosome 15 Proximal Arm|Chromosome 15 Short Arm	Proximal (short) arm of chromosome 15
C13541	_16p	Chromosome_Arm	16p|Chromosome 16 Proximal Arm|Chromosome 16 Short Arm	Proximal (short) arm of chromosome 16
C13542	_16q	Chromosome_Arm	16q|Chromosome 16 Distal Arm|Chromosome 16 Long Arm	Distal (long) arm of chromosome 16
C13543	_17q	Chromosome_Arm	17q|Chromosome 17 Distal Arm|Chromosome 17 Long Arm	Distal (long) arm of chromosome 17
C13544	_18p	Chromosome_Arm	18p|Chromosome 18 Proximal Arm|Chromosome 18 Short Arm	Proximal (short) arm of chromosome 18
C13545	_19p	Chromosome_Arm	19p|Chromosome 19 Proximal Arm|Chromosome 19 Short Arm	Proximal (short) arm of chromosome 19
C13546	_19q	Chromosome_Arm	19q|Chromosome 19 Distal Arm|Chromosome 19 Long Arm	Distal (long) arm of chromosome 19
C13547	_2p	Chromosome_Arm	2p|Chromosome 2 Proximal Arm|Chromosome 2 Short Arm	Proximal (short) arm of chromosome 2
C13548	_2q	Chromosome_Arm	2q|Chromosome 2 Distal Arm|Chromosome 2 Long Arm	Distal (long) arm of chromosome 2
C13549	_20q	Chromosome_Arm	20q|Chromosome 20 Distal Arm|Chromosome 20 Long Arm	Distal (long) arm of chromosome 20
C13550	_20p	Chromosome_Arm	20p|Chromosome 20 Proximal Arm|Chromosome 20 Short Arm	Proximal (short) arm of chromosome 20
C13551	_21p	Chromosome_Arm	21p|Chromosome 21 Proximal Arm|Chromosome 21 Short Arm	Proximal (short) arm of chromosome 21
C13552	_21q	Chromosome_Arm	21q|Chromosome 21 Distal Arm|Chromosome 21 Long Arm	Distal (long) arm of chromosome 21
C13553	_22q	Chromosome_Arm	22q|Chromosome 22 Distal Arm|Chromosome 22 Long Arm	Distal (long) arm of chromosome 22
C13554	_22p	Chromosome_Arm	22p|Chromosome 22 Proximal Arm|Chromosome 22 Short Arm	Proximal (short) arm of chromosome 22
C13555	_3q	Chromosome_Arm	3q|Chromosome 3 Distal Arm|Chromosome 3 Long Arm	Distal (long) arm of chromosome 3
C13556	_4q	Chromosome_Arm	4q|Chromosome 4 Distal Arm|Chromosome 4 Long Arm	Distal (long) arm of chromosome 4
C13557	_4p	Chromosome_Arm	4p|Chromosome 4 Proximal Arm|Chromosome 4 Short Arm	Proximal (short) arm of chromosome 4
C13558	_5p	Chromosome_Arm	5p|Chromosome 5 Proximal Arm|Chromosome 5 Short Arm	Proximal (short) arm of chromosome 5
C13559	_6p	Chromosome_Arm	6p|Chromosome 6 Proximal Arm|Chromosome 6 Short Arm	Proximal (short) arm of chromosome 6
C13560	_6q	Chromosome_Arm	6q|Chromosome 6 Distal Arm|Chromosome 6 Long Arm	Distal (long) arm of chromosome 6
C13561	_7p	Chromosome_Arm	7p|Chromosome 7 Proximal Arm|Chromosome 7 Short Arm	Proximal (short) arm of chromosome 7
C13562	_8q	Chromosome_Arm	8q|Chromosome 8 Distal Arm|Chromosome 8 Long Arm	Distal (long) arm of chromosome 8
C13563	_9p	Chromosome_Arm	9p|Chromosome 9 Proximal Arm|Chromosome 9 Short Arm	Proximal (short) arm of chromosome 9
C13564	_9q	Chromosome_Arm	9q|Chromosome 9 Distal Arm|Chromosome 9 Long Arm	Distal (long) arm of chromosome 9
C13565	Xp	Chromosome_Arm	Xp|Chromosome X Proximal Arm|Chromosome X Short Arm	Proximal (short) arm of chromosome X
C13566	Xq	Chromosome_Arm	Xq|Chromosome X Distal Arm|Chromosome X Long Arm	Distal (long) arm of chromosome X
C13567	_6p25-p23	Chromosome_Band	6p25-p23	A chromosome band present on 6p
C13568	_1p32-p31	Chromosome_Band	1p32-p31	A chromosome band present on 1p
C13569	_19p13_2	Chromosome_Band	19p13.2	A chromosome band present on 19p
C13570	_11p11_2	Chromosome_Band	11p11.2	A chromosome band present on 11p
C13571	_4q11-q12	Chromosome_Band	4q11-q12	A chromosome band present on 4q
C13572	_12p12_1	Chromosome_Band	12p12.1	A chromosome band present on 12p
C13573	_1p35-p34_3	Chromosome_Band	1p35-p34.3	A chromosome band present on 1p
C13574	_8q13	Chromosome_Band	8q13	A chromosome band present on 8q
C13575	_1p32-p31_or_1p31-q12	Retired_Concepts	1p32-p31 or 1p31-q12
C13576	_18q21_1	Chromosome_Band	18q21.1	A chromosome band present on 18q
C13577	_16q22-q23	Chromosome_Band	16q22-q23	A chromosome band present on 16q
C13578	_17q25	Chromosome_Band	17q25	A chromosome band present on 17q
C13579	_6q24-q27	Chromosome_Band	6q24-q27	A chromosome band present on 6q
C13580	_14q23	Chromosome_Band	14q23	A chromosome band present on 14q
C13581	_5q21-q22	Chromosome_Band	5q21-q22	A chromosome band present on 5q
C13582	Xq26_3-q27_1	Chromosome_Band	Xq26.3-q27.1	A chromosome band present on Xq
C13583	_12q13-q14	Chromosome_Band	12q13-q14	A chromosome band present on 12q
C13584	_19p13_1-p13_2	Chromosome_Band	19p13.1-p13.2	A chromosome band present on 19p
C13585	_8q11	Chromosome_Band	8q11	A chromosome band present on 8q
C13586	_1p34	Chromosome_Band	1p34	A chromosome band present on 1p
C13587	_2p16	Chromosome_Band	2p16	A chromosome band present on 2p
C13588	_6q22-q23	Chromosome_Band	6q22-q23	A chromosome band present on 6q
C13589	_8q22	Chromosome_Band	8q22	A chromosome band present on 8q
C13590	_20q13_1	Chromosome_Band	20q13.1	A chromosome band present on 20q
C13591	_8q24	Chromosome_Band	8q24	A chromosome band present on 8q
C13592	_1p34_3	Chromosome_Band	1p34.3	A chromosome band present on 1p
C13593	_2p24_1	Chromosome_Band	2p24.1	A chromosome band present on 2p
C13594	_1p36_3-p36_2	Chromosome_Band	1p36.3-p36.2	A chromosome band present on 1p
C13595	_22q12_2	Chromosome_Band	22q12.2	A chromosome band present on 22q
C13596	_10q24	Chromosome_Band	10q24	A chromosome band present on 10q
C13597	_3p23-p21	Chromosome_Band	3p23-p21	A chromosome band present on 3p
C13598	_8q24_1	Chromosome_Band	8q24.1	A chromosome band present on 8q
C13599	_1p13	Chromosome_Band	1p13	A chromosome band present on 1p
C13600	_1q23-q31	Chromosome_Band	1q23-q31	A chromosome band present on 1q
C13601	_15q25-q26	Chromosome_Band	15q25-q26	A chromosome band present on 15q
C13602	_22q12_3-q13_1	Chromosome_Band	22q12.3-q13.1	A chromosome band present on 22q
C13603	_6p21	Chromosome_Band	6p21	A chromosome band present on 6p
C13604	_9q31	Chromosome_Band	9q31	A chromosome band present on 9q
C13605	_3p25	Chromosome_Band	3p25	A chromosome band present on 3p
C13606	_7p22-p15	Chromosome_Band	7p22-p15	A chromosome band present on 7p
C13607	_2cen-q13	Chromosome_Band	2cen-q13	A chromosome band present on 22q
C13608	_13q14_2	Chromosome_Band	13q14.2	A chromosome band present on 13q
C13609	_2p13-p12	Chromosome_Band	2p13-p12	A chromosome band present on 2p
C13610	_10q11_2	Chromosome_Band	10q11.2	A chromosome band present on 10q
C13611	_6q21-q22	Chromosome_Band	6q21-q22	A chromosome band present on 6q
C13612	_1q22-q24	Chromosome_Band	1q22-q24	A chromosome band present on 1q
C13613	_22q11_2	Chromosome_Band	22q11.2	A chromosome band present on 22q
C13614	_11p12-p11_22	Chromosome_Band	11p12-p11.22	A chromosome band present on 11p
C13615	_20q11_2_or_20q11_2-q13	Retired_Concepts	20q11.2 or 20q11.2-q13
C13616	_11p15	Chromosome_Band	11p15	A chromosome band present on 11p
C13617	_6p21_1-p21_3	Chromosome_Band	6p21.1-p21.3	A chromosome band present on 6p
C13618	_19q13	Chromosome_Band	19q13	A chromosome band present on 19q
C13619	_17q11_2	Chromosome_Band	17q11.2	A chromosome band present on 17q
C13620	_3p22	Chromosome_Band	3p22	A chromosome band present on 3p
C13621	_3q27	Chromosome_Band	3q27	A chromosome band present on 3q
C13622	_17q11_2-q12	Chromosome_Band	17q11.2-q12	A chromosome band present on 17q
C13623	_3p24_1-p22	Chromosome_Band	3p24.1-p22	A chromosome band present on 3p
C13624	_21q22_1	Chromosome_Band	21q22.1	A chromosome band present on 21q
C13625	_7q33-q35	Chromosome_Band	7q33-q35	A chromosome band present on 7q
C13626	_3q21-q25	Chromosome_Band	3q21-q25	A chromosome band present on 3q
C13627	_6p21_3	Chromosome_Band	6p21.3	A chromosome band present on 6p
C13628	_17p13_1	Chromosome_Band	17p13.1	A chromosome band present on 17p
C13629	_1q42_1	Chromosome_Band	1q42.1	A chromosome band present on 1q
C13630	_1p36	Chromosome_Band	1p36	A chromosome band present on 1p
C13631	_3p21-p14	Chromosome_Band	3p21-p14	A chromosome band present on 3p
C13632	_11p13	Chromosome_Band	11p13	A chromosome band present on 11p
C13633	_18p11_31-p11_21	Chromosome_Band	18p11.31-p11.21	A chromosome band present on 18p
C13634	Retinoic_Acid_Response_Element	Response_Elements	Retinoic Acid Response Element|RARE	A cis-acting transcription regulatory element.  It is bound by the retinoic acid receptors.
C13635	bHLH-Zip_Domain	Helix-Loop-Helix_Domain	bHLH-Zip Domain	Tripartite DNA binding domain containing a basic region, a helix-loop-helix, and a leucine zipper.
C13636	HD-ZIP_Domain	Homeo_Domain	HD-ZIP Domain	Bipartite DNA binding domain containing a homeo domain and a leucine zipper.
C13637	HT-Zip_Domain	Helix-Turn-Helix_Motif	HT-Zip Domain	Bipartite DNA binding domain containing a helix-turn and a leucine zipper.
C13638	_15q21-q22	Chromosome_Band	15q21-q22	A chromosome band present on 15q
C13639	Poly-A_Addition_Site	Gene_Structure	Poly-A Addition Site	The site within the 3' untranslated region of a gene where polyadenylation of the transcribed RNA takes place.  Usually consists of the sequence AATAAA.
C13640	_5q21	Chromosome_Band	5q21	A chromosome band present on 5q
C13641	_10q24_3-10qter	Chromosome_Band	10q24.3-10qter	A chromosome band present on 10q
C13642	_15q23-15q24	Chromosome_Band	15q23-15q24	A chromosome band present on 15q
C13643	_16q22_2	Chromosome_Band	16q22.2	A chromosome band present on 16q
C13644	_2p23	Chromosome_Band	2p23	A chromosome band present on 2p
C13645	_9q34	Chromosome_Band	9q34	A chromosome band present on 9q
C13646	_16p13_3	Chromosome_Band	16p13.3	A chromosome band present on 16p
C13647	_2p22-p21	Chromosome_Band	2p22-p21	A chromosome band present on 2p
C13648	_2q32	Chromosome_Band	2q32	A chromosome band present on 2q
C13649	_7p22	Chromosome_Band	7p22	A chromosome band present on 7p
C13650	_10q23_31	Chromosome_Band	10q23.31	A chromosome band present on 10q
C13651	_19p13	Chromosome_Band	19p13	A chromosome band present on 19p
C13652	_1p13_3	Chromosome_Band	1p13.3	A chromosome band present on 1p
C13653	_6q14_3-16_1	Chromosome_Band	6q14.3-16.1	A chromosome band present on 6q
C13654	_12q12-12q14	Chromosome_Band	12q12-12q14	A chromosome band present on 12q
C13655	_19q13_2	Chromosome_Band	19q13.2	A chromosome band present on 19q
C13656	_14q12	Chromosome_Band	14q12	A chromosome band present on 14q
C13657	Nucleosomal_Repeat_Length	Chromatin_Structure	Nucleosomal Repeat Length	Nucleosomal repeat length is approximately 200 base pairs of DNA within which 146 base pairs are highly protected. (NCI)
C13658	_3p14_2	Chromosome_Band	3p14.2	A chromosome band present on 3p
C13659	_16p13_1	Chromosome_Band	16p13.1	A chromosome band present on 16p
C13660	Translocation_Breakpoint	DNA_Sequence	Translocation Breakpoint	The point on a chromosome where the normal DNA sequence is juxtaposed with DNA from another chromosome.  Usually expressed as a band number designation (eg. t(9;22) (q34;q11) Philadelphia Chromosome)
C13661	Cyclic_AMP_Response_Element	Response_Elements	Cyclic AMP Response Element|CRE|cAMP Response Element	A promoter sequence which interacts with CRE binding proteins to modulate gene expression in response to the level of cAMP in the cell.
C13662	Androgen_Response_Element	Response_Elements	Androgen Response Element|ARE	Androgen response element is the target binding element for activated androgen receptor homodimer.  The consensus sequence for this high-affinity androgen receptor-binding is the palindromic sequence GGT/AACAnnnTGTTCT, though could deviate considerably in natural promoter sequences.  The most well-characterized in this regard is the promoter of the PSA (prostate-specific antigen) gene.(NCI)
C13663	SANT_Domain	DNA_Binding_Domain	SANT Domain|MYB-Like DNA-Binding Domain|SWI3/ADA2/N-CoR/TFIIIB Domain	The SANT domain is found in several transcriptional regulatory proteins identified through consistent homology to the c-MYB repeat DNA binding domain, suggesting that SANT domains also bind DNA. Folded into three alpha helices as doublets or singlets in many proteins, the SANT domain family specifically recognizes the sequence YAAC(G/T)G. The SANT domain is a repeated motif in N-CoR, the nuclear receptor co-repressor. Single copies of SANT occur in yeast nuclear chromatin remodeling proteins SWI3 (SWI/SNF transcription subunit), ADA2 (ADA adaptor/HAT complex), and a TFIIIB transcription subunit. SANT domains may mediate functional interactions with histone N-terminal tails. (NCI)
C13664	_10q11	Chromosome_Band	10q11	A chromosome band present on 10q
C13665	_17q23-q24	Chromosome_Band	17q23-q24	A chromosome band present on 17q
C13666	_3q25_1-q26_1	Chromosome_Band	3q25.1-q26.1	A chromosome band present on 3q
C13667	_4q31_1-q31_2	Chromosome_Band	4q31.1-q31.2	A chromosome band present on 4q
C13668	_7q35-q36	Chromosome_Band	7q35-q36	A chromosome band present on 7q
C13669	_9p22_3	Chromosome_Band	9p22.3	A chromosome band present on 9p
C13670	Xq26_1	Chromosome_Band	Xq26.1	A chromosome band present on Xq
C13671	Ligand_Binding_Domain	Protein_Domain	Ligand Binding Domain|Binding Site|Binding Site Domain	A Binding Site Domain is a region of protein that physically interacts stereospecifically, and usually at high affinity, with a specific ligand, substrate, or a specific domain of some complex target biomolecule, such as a protein, lipid, carbohydrate, or nucleic acid. Typically, but not necessarily, the interaction results in protein conformational alteration and functional modification.
C13672	LIM_Domain	Metal_Binding_Site|Protein_Binding_Domain	LIM Domain|CRR Domain|Cysteine Rich Region	The LIM domain is a zinc binding, cysteine rich motif consisting of two tandemly repeated zinc fingers. Unlike GATA type zinc fingers, LIM domains do not bind DNA but instead mediate protein-protein interactions. Functionally, LIM domain containing proteins have been implicated in cell lineage specification, cytoskeletal organization, and organ development.
C13673	_19p13_3	Chromosome_Band	19p13.3	A chromosome band present on 19p
C13674	_12q14_3-q15	Chromosome_Band	12q14.3-q15	A chromosome band present on 12q
C13675	_9q22_3	Chromosome_Band	9q22.3	A chromosome band present on 9q
C13676	_8q24_12-q24_13	Chromosome_Band	8q24.12-q24.13	A chromosome band present on 8q
C13677	_6p24	Chromosome_Band	6p24	A chromosome band present on 6p
C13678	_7p12_3-p12_1	Chromosome_Band	7p12.3-p12.1	A chromosome band present on 7p
C13679	_4q25-q27	Chromosome_Band	4q25-q27	A chromosome band present on 4q
C13680	_15q15-q21_1	Chromosome_Band	15q15-q21.1	A chromosome band present on 15q
C13681	_8p11_2-p11_1	Chromosome_Band	8p11.2-p11.1	A chromosome band present on 8p
C13682	_10q26	Chromosome_Band	10q26	A chromosome band present on 10q
C13683	_19p13_1-p12	Chromosome_Band	19p13.1-p12	A chromosome band present on 19p
C13684	_16q22	Chromosome_Band	16q22	A chromosome band present on 16q
C13685	_4q12-q13	Chromosome_Band	4q12-q13	A chromosome band present on 4q
C13686	_3q26_3-q27	Chromosome_Band	3q26.3-q27	A chromosome band present on 3q
C13687	_12q12-q13	Chromosome_Band	12q12-q13	A chromosome band present on 12q
C13688	_22q11_21	Chromosome_Band	22q11.21	A chromosome band present on 22q
C13689	_8q13-qter	Chromosome_Band	8q13-qter	A chromosome band present on 8q
C13690	_6q22	Chromosome_Band	6q22	A chromosome band present on 6q
C13691	_13q12-q13	Chromosome_Band	13q12-q13	A chromosome band present on 13q
C13692	_8q24_11-q24_13	Chromosome_Band	8q24.11-q24.13	A chromosome band present on 8q
C13693	_11p12-p11	Chromosome_Band	11p12-p11	A chromosome band present on 11p
C13694	_1p36_13-p36_11	Chromosome_Band	1p36.13-p36.11	A chromosome band present on 1p
C13695	_17q21_3	Chromosome_Band	17q21.3	A chromosome band present on 17q
C13696	_13q14_1-q14_2	Chromosome_Band	13q14.1-q14.2	A chromosome band present on 13q
C13697	_18p11_3	Chromosome_Band	18p11.3	A chromosome band present on 18p
C13698	_20q12-q13	Chromosome_Band	20q12-q13	A chromosome band present on 20q
C13699	_10q21	Chromosome_Band	10q21	A chromosome band present on 10q
C13700	_7q21_1	Chromosome_Band	7q21.1	A chromosome band present on 7q
C13701	_19q13_3-q13_4	Chromosome_Band	19q13.3-q13.4	A chromosome band present on 19q
C13702	_8p23_1-p21_3	Chromosome_Band	8p23.1-p21.3	A chromosome band present on 8p
C13703	_5q33_2-q33_3	Chromosome_Band	5q33.2-q33.3	A chromosome band present on 5q
C13704	_1q21-q22	Chromosome_Band	1q21-q22	A chromosome band present on 1q
C13705	_3p24_3	Chromosome_Band	3p24.3	A chromosome band present on 3p
C13706	_12p12_3	Chromosome_Band	12p12.3	A chromosome band present on 12p
C13707	_3q26	Chromosome_Band	3q26	A chromosome band present on 3q
C13708	_3p21	Chromosome_Band	3p21	A chromosome band present on 3p
C13709	_4q25	Chromosome_Band	4q25	A chromosome band present on 4q
C13710	_3p26-p25	Chromosome_Band	3p26-p25	A chromosome band present on 3p
C13711	_15q22-q24	Chromosome_Band	15q22-q24	A chromosome band present on 15q
C13712	_2q31-q33	Chromosome_Band	2q31-q33	A chromosome band present on 2q
C13713	Male_Genital_System_Fluid_or_Secretion	Body_Fluid_or_Substance	Male Genital System Fluid or Secretion|Genital System, Male, Fluids, Secretions|Male Genital System Fluids and Secretions|Sperm, Fluids, Secretions	Sperm and the fluid it is suspended in.
C13714	_5q35_1	Chromosome_Band	5q35.1	A chromosome band present on 5q
C13716	Internal_Ribosome_Entry_Site	Regulatory_Element	Internal Ribosome Entry Site|IRES|Ribosome Entry Site	Internal ribosome entry site (IRES) is a translational cis-acting element that directs ribosomes to the start codon by a cap-independent mechanism.  IRESs are usually about 450 nucleotides in length and were first identified in picornavirus RNAs.  IRESs can fold into a stable secondary hairpin structure to be incompatible with efficient translation by ribosomal scanning. (NCI)
C13717	Anatomic_Sites	Other_Anatomic_Concept	Anatomic Site|Anatomic Sites	Named locations of, or within, the body.
C13718	Hypoxia-Responsive_Elements	Response_Elements	Hypoxia-Responsive Elements	DNA sequences in a gene's promoter region that mediate expression during hypoxia.  Since unlike normal tissues, solid tumors frequently have regions of hypoxia, suicide genes controlled by hypoxia-responsive elements may provide a means for cancer-specific gene therapy.
C13719	ETS_Domain	DNA_Binding_Domain	ETS Domain	Usually C-terminal, the conserved ETS (Erythroblast Transformation Specific) Domain of 85-90 amino acids, rich in positively-charged and aromatic residues, binds to purine-rich DNA with a GGAA/T core. Identified in many transcription factors, many ETS-proteins modulate gene expression through protein-protein interactions with other transcriptional factors and co-factors. Most ETS-proteins are nuclear targets of RAS-MAPK signaling; some affect cell proliferation or apoptosis-related genes. Several are expressed in specific cell lineages to regulate development and differentiation. Deregulated ETS-gene expression or chimeric ETS-proteins are associated with leukemias, some tumors, invasion and metastasis. (NCI)
C13720	RNA_Recognition_Motif	Ligand_Binding_Domain	RNA Recognition Motif|Putative RNA-Binding Region|RBD|RNA Binding Domain|RNP Domain|RNP Motif|RNP-1 Signature|RRM	RNA Binding Domains, such as the RRM, RGG box, and KH domain, mediate the interaction of RNAs with RNA-binding proteins. RRMs of about 90 amino acids consist of a four-stranded beta sheet adjacent to two alpha helixes. Within RRMs, conserved RNP-1 and RNP-2 motifs on the central beta sheets lie side by side; their side chains contact RNA. Found in hnRNP proteins, the RGG box is an RNA-binding motif containing five Arg-Gly-Gly repeats with intervening aromatic residues. The KH domain is found in several RNA-binding proteins in multiple repeats interspersed with RGG boxes. (NCI)
C13721	bZIP_Domain	DNA_Binding_Domain	bZIP Domain|Basic Leucine Zipper	Bipartite DNA binding domain containing a basic region directly interacting with DNA, and a leucine zipper mediating dimerization through contacts with a protein partner.
C13722	Respiratory_System_Fluid_or_Secretion	Body_Fluid_or_Substance	Respiratory System Fluid or Secretion|Respiratory System Fluid and Secretion|Respiratory System Fluids and Secretions|Respiratory System-Fluids, Secretions	Fluids and secretions relating to the respiratory system.
C13723	Repair_Complex	Protein_or_Riboprotein_Complex	Repair Complex	Initial or intermediate protein-DNA complexes present during the process of DNA repair.
C13724	Central_DNA_Flap_Sequence	DNA_Sequence	Central DNA Flap Sequence	In Lentivirus, a central strand displacement event consecutive to central initiation and termination of plus strand synthesis creates a plus strand overlap: the central DNA flap.  This feature promotes efficient nuclear import and viral replication in non-dividing cells. (from Cell 2000;101:173-85)
C13725	G-Quartets	DNA_Structure	G-Quartets|G-Quadruplex|G-Quadruplexes|G-Quadruplexes DNA|G-Quartet Structures|G-Tetrads|G4-DNA	G-quadruplexes are multi-stranded structures held together by square planes of four guanines ('G-quartets') interacting by forming Hoogsteen hydrogen bonds. G-quartet structures has been developed as novel anti-HIV agents. Several critical structure-activity relationships between HIV-1 integrase and G-quartet oligonucleotides have been demonstrated.
C13726	_1p32-q12	Chromosome_Band	1p32-q12	A chromosome band present on 1p
C13727	t_12_21_p13_q22	Chromosomal_Translocation	t(12;21)(p13;q22)	t(12;21) is a chromosomal translocation, involved in TEL-AML1 oncogene formation, that produces a chimeric gene encoding a protein consisting of the N-terminal HLH domain of the TEL ETS-like transcription factor fused with a nearly complete AML1 protein. t(12;21) is the most frequent translocation causing ALL, accounting for 20% of ALL cases.
C13728	_15q23-q25	Chromosome_Band	15q23-q25	A chromosome band present on 15q
C13729	_21q22_2	Chromosome_Band	21q22.2	A chromosome band present on 21q
C13730	_4q13-q21	Chromosome_Band	4q13-q21	A chromosome band present on 4q
C13731	Intraventricular	Anatomy_Modifier	Intraventricular
C13732	Bromodomain	Protein_Binding_Domain	Bromodomain	A motif common in chromatin remodeling factors. It constitutes an acetyl-lysine binding domain. Bromodomain-containing proteins may recruit remodeling complexes to acetylated chromatin regions.
C13733	_5p15_33	Chromosome_Band	5p15.33	A chromosome band present on 5p
C13734	Regulatory_Element	Gene_Structure	Regulatory Element|Regulatory Region	Any DNA sequence involved in the regulation of genetic processes such as transcription and replication.
C13735	Plasma_Membrane	Cellular_Membrane|Membranous_Cytoplasmic_Organelle	Plasma Membrane|Cell Membrane	The semipermeable membrane that encloses the cytoplasm of a cell. Also called cytomembrane, plasmalemma, plasma membrane.(The American Heritage Dictionary)
C13736	Zonula_Adherens	Anchoring_Junction	Zonula Adherens|AJ|Adherens Junction|Intermediate Junction	The best understood cell-cell junction required for adhesion between cells in the epithelium. It seals adjacent epithelial cells together, preventing the passage of most dissolved molecules from one side of the epithelial sheet to the other. Adherens junctions are located most apically in insect cells and just basal to the tight junction in vertebrate cells. It is formed by the fusion of adjacent cell membranes which encircle the apical cell surface like a belt or fence based on homophilic association between molecules of the transmembrane protein E-cadherin, which is linked on its cytoplasmic side to the actin cytoskeleton via b-catenin (Drosophila Armadillo) and a-catenin. The adherens junctions and associated cytoskeleton form a continuous band (zonula adherens) around the apical circumference of each cell, thus uniting the cells of the epithelium into a coherent sheet.
C13737	_20S_Proteasome	Subcellular_Structure	20S Proteasome|20S Catalytic Proteasome|20S Core Proteasome|20S Proteosome	The 20S proteasome, as proteolytic core of the proteasome system, is essential in ATP dependent ubiquitin protein complex degradation and in antigen processing in antigen presenting cell. It has 13-15 subunits each of which has three or four different peptidase activities. 26S proteasomes may be formed in an ATP dependent fashion from a 20S proteasome and additional components, CF1 (660 kD), CF2 (250 kD) and CF3 (600 kD). The 20S proteasome interacts with additional subunits, PA700 and PA28, to form an ATP-dependent multicatalytic proteinase complex (MPC) involved in the ATP ubiquitin degradation pathway.
C13738	Conformation	Miscellaneous_Molecular_Biology_Terms	Conformation	The three-dimensional arrangement of side groups on a molecule which can freely rotate into different positions without breaking any bonds. (On-line Medical Dictionary)
C13739	Blastocyst	Embryo	Blastocyst|Blastosphere|Blastula	An embryo made up of two groups of cells. One group will develop into the fetus and the other will become the placenta.
C13740	Inner_Cell_Mass	Other_Embryologic_Structure	Inner Cell Mass|Embryoblast
C13741	AT_Hook_Motif	HMG_Domain	AT Hook Motif|ATH	Highly conserved peptide motifs of the HMG-I(Y) proteins that preferentially bind, in vivo and in vitro, to the narrow minor groove of stretches of AT-rich DNA. The AT Hook Motif tethers and unbends the minor groove of the DNA with very little specificity for the DNA sequence. The AT hook motif has a narrow DNA recognize surface which is devoid of hydrophobic amino acids and does not significantly distort the B-form DNA structure.
C13742	Minor_Groove	DNA_Structure	Minor Groove	The smaller of the two types of spiral grooves found on a right-handed DNA double helix; located between the sugar phosphate backbones of two DNA strands.
C13743	Major_Groove	DNA_Structure	Major Groove	One of the two types of grooves found in a right-handed double helix, running between the sugar phosphate backbones of each strand.
C13744	HMG-Box	HMG_Domain	HMG-Box|HMG-1 Domain	The HMG-Box Domain binds to and bends the minor groove of the DNA. This domain can recognize and bind to altered DNA conformations, such as stem-loops, four-way junctions, and specifically kinked or underwound DNA. (Mol Cell Biol 1999 Aug;19(8):5237-46)
C13745	Nucleosome_Binding_Domain	HMG_Domain	Nucleosome Binding Domain|NBD	The Nucleosomal Binding Domain anchors HMG-14 and HMG-17, two canonical HMG proteins, to nucleosomes. HMG-14 and HMG-17 are the only nuclear proteins known to specifically recognize the genetic structure of the 146-bp nucleosome, i.e., the building block of the chromatin fiber. Although the target of HMG-14/-17 is the nucleosome, the main function of these proteins is to change the architecture of the higher-order chromatin structure. These changes are mediated through the C-terminal region of the proteins. The nucleosomal binding domain anchors these HMG proteins to the nucleosome cores to facilitate HMG-14/-17-dependent changes in chromatin structure.
C13746	Ring_Finger_Domain	Metal_Binding_Site|Protein_Binding_Domain	Ring Finger Domain|Ring Finger|Ring Finger Motif|Ring-Type Zinc Finger Domain	RING finger domains are defined by the consensus sequence CX2CX(9-39)CX(1-3)HX(2-3)C/HX2CX(4-48)CX2C with the Cys and His representing zinc binding residues. RING fingers are further divided into RING-HC and RING-H2, depending on whether a Cys or His occupies the fifth coordination site. While RING fingers are structurally diverse, all contain two interleaved Zn2+ binding sites. Binding of the Cbl RING domain to the E2 protein, UbcH7, occurs between a groove within the RING domain and two loops in the E2 fold of UbcH7. Van der Waals interactions involving hydrophobic residues in both the E2 and RING domains support the Cbl-UbcH7 binding, though this is not universal as the RING-E2 pair of Rad18p and Rad6p/Ubc2p interact by hydrogen bonding of polar residues.
C13747	_14q11	Chromosome_Band	14q11	A chromosome band present on 14q
C13748	_3p21_3-p21_2	Chromosome_Band	3p21.3-p21.2	A chromosome band present on 3p
C13749	Xq28	Chromosome_Band	Xq28	A chromosome band present on Xq
C13750	_5q11-q12	Chromosome_Band	5q11-q12	A chromosome band present on 5q
C13751	_13q22-q34	Chromosome_Band	13q22-q34	A chromosome band present on 13q
C13752	_5q13-q14	Chromosome_Band	5q13-q14	A chromosome band present on 5q
C13753	_7q36_1	Chromosome_Band	7q36.1	A chromosome band present on 7q
C13754	_11q22-q23	Chromosome_Band	11q22-q23	A chromosome band present on 11q
C13755	Xq25	Chromosome_Band	Xq25	A chromosome band present on Xq
C13756	_20q13_3	Chromosome_Band	20q13.3	A chromosome band present on 20q
C13757	_22q11-q13	Chromosome_Band	22q11-q13	A chromosome band present on 22q
C13758	_3p26_2	Chromosome_Band	3p26.2	A chromosome band present on 3p
C13759	_1q42-q43	Chromosome_Band	1q42-q43	A chromosome band present on 1q
C13760	_5q12_2-q13_3	Chromosome_Band	5q12.2-q13.3	A chromosome band present on 5q
C13761	_3q22_1	Chromosome_Band	3q22.1	A chromosome band present on 3q
C13762	_19p13_3-p13_2	Chromosome_Band	19p13.3-p13.2|19p13.3-2	A chromosome band present on 19p
C13763	_2q35	Chromosome_Band	2q35	A chromosome band present on 2q
C13764	_3q21	Chromosome_Band	3q21	A chromosome band present on 3q
C13765	_8q11_2	Chromosome_Band	8q11.2	A chromosome band present on 8q
C13766	_22q13_1	Chromosome_Band	22q13.1	A chromosome band present on 22q
C13767	_2q21	Chromosome_Band	2q21	A chromosome band present on 2q
C13768	_6p12	Chromosome_Band	6p12	A chromosome band present on 6p
C13769	_7q21_3-q22_1	Chromosome_Band	7q21.3-q22.1	A chromosome band present on 7q
C13770	_2q33	Chromosome_Band	2q33	A chromosome band present on 2q
C13771	_7q21_3	Chromosome_Band	7q21.3	A chromosome band present on 7q
C13772	_2q22-q23	Chromosome_Band	2q22-q23	A chromosome band present on 2q
C13773	_7q22_1	Chromosome_Band	7q22.1	A chromosome band present on 7q
C13774	_8p12-p11_2	Chromosome_Band	8p12-p11.2	A chromosome band present on 8p
C13775	_5q23-q31	Chromosome_Band	5q23-q31	A chromosome band present on 5q
C13776	_1q41	Chromosome_Band	1q41	A chromosome band present on 1q
C13777	_6p21_1	Chromosome_Band	6p21.1	A chromosome band present on 6p
C13778	_7p12-p11_2	Chromosome_Band	7p12-p11.2	A chromosome band present on 7p
C13779	Xq13_1	Chromosome_Band	Xq13.1	A chromosome band present on Xq
C13780	_6q27	Chromosome_Band	6q27	A chromosome band present on 6q
C13781	_3q21-q28	Chromosome_Band	3q21-q28	A chromosome band present on 3q
C13782	_14q11_2	Chromosome_Band	14q11.2	A chromosome band present on 14q
C13783	_3q13_31	Chromosome_Band	3q13.31	A chromosome band present on 3q
C13784	_8q24_12	Chromosome_Band	8q24.12	A chromosome band present on 8q
C13785	_1p22	Chromosome_Band	1p22	A chromosome band present on 1p
C13786	_16q24_3	Chromosome_Band	16q24.3	A chromosome band present on 16q
C13787	_8q12-q13	Chromosome_Band	8q12-q13	A chromosome band present on 8q
C13788	Xq11-q13	Chromosome_Band	Xq11-q13	A chromosome band present on Xq
C13789	_10p15_1	Chromosome_Band	10p15.1	A chromosome band present on 10p
C13790	_20q13_33	Chromosome_Band	20q13.33	A chromosome band present on 20q
C13791	_10q24-q25_2	Chromosome_Band	10q24-q25.2	A chromosome band present on 10q
C13792	Xq22_1	Chromosome_Band	Xq22.1	A chromosome band present on Xq
C13793	_5q11_2-q13_1	Chromosome_Band	5q11.2-q13.1	A chromosome band present on 5q
C13794	_11p15_3	Chromosome_Band	11p15.3	A chromosome band present on 11p
C13795	_6p21_31	Chromosome_Band	6p21.31	A chromosome band present on 6p
C13796	_1p35_2	Chromosome_Band	1p35.2	A chromosome band present on 1p
C13797	_1p13_1	Chromosome_Band	1p13.1	A chromosome band present on 1p
C13798	_6q22_1-q22_3	Chromosome_Band	6q22.1-q22.3	A chromosome band present on 6q
C13799	_11q22_3	Chromosome_Band	11q22.3	A chromosome band present on 11q
C13800	_12q15	Chromosome_Band	12q15	A chromosome band present on 12q
C13801	_1p22_1	Chromosome_Band	1p22.1	A chromosome band present on 1p
C13802	Beta_Sheet	Secondary_Protein_Structure	Beta Sheet|Beta Pleated Sheet	In a b-sheet two or more polypeptide chains run alongside each other and are linked in a regular manner by hydrogen bonds between the main chain C=O and N-H groups. The R-groups (side chains) of neighbouring residues in a b-strand point in opposite directions; beta sheets can be parallel, anti-parallel or mixed. (from expasy.org)
C13803	Long_Interspersed_Element	Chromosome_Structure	Long Interspersed Element|LINE|LINES	LINEs.  Highly repeated sequences, 6000-8000 base pairs in length that contain RNA polymerase II promoters.  They also have a region with sequence similarity to the reverse transcriptase of retroviruses, but they do not contain LTRs (long terminal repeats).
C13804	Short_Interspersed_Element	Repetitive_Sequence	Short Interspersed Element|SINE|SINES	SINEs.  Short, 100-300 bases long, highly repeated sequences which contain RNA polymerase III promoters. The primate Alu and the rodent B1 SINEs are derived from 7SL RNA, the RNA component of the signal recognition particle. Most other SINEs are derived from tRNAs including the MIRs (mammalian-wide interspersed repeats).
C13805	Erythroid	Anatomy_Modifier	Erythroid	1) Reddish in color. 2) relating to erythrocytes or their precursors.
C13806	Immunoglobulin_Domain	Protein_Domain	Immunoglobulin Domain|Immunoglobulin-Like Domain	The major histocompatibility complex (MHC) molecules are made of 2 chains, alpha and beta. In class I, the alpha chain is composed of 3 extracellular domains, a transmembrane region and a cytoplasmic tail while the beta chain is of a single extracellular domain. In class II, both the alpha and the beta chains are composed of 2 extracellular domains, a transmembrane region and a cytoplasmic tail. The immunoglobulin (Ig) constant chain domains and a single extracellular domain in each type of MHC chains are homologous and approximately one hundred amino acids long, and include a conserved intra-domain disulfide bond. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions, e.g., antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions. (InterPro IPR007110)
C13807	Intraepithelial	Anatomy_Modifier	Intraepithelial|intraepithelial	(in-tra-eh-pih-THEEL-ee-ul) Within the layer of cells that form the surface or lining of an organ.
C13808	Intrahepatic	Anatomy_Modifier	Intrahepatic|intrahepatic	(in-tra-hep-AT-ik) Within the liver.
C13809	Nuclear_Lamina	Cell_Part	Nuclear Lamina	The nuclear lamina is a proteinaceous filamentous meshwork of lamin proteins interacting with integral proteins of the inner nuclear membrane, including emerin, and is thought to play a role in nuclear stability, chromatin structure, and gene expression. Lamins are highly conserved in evolution and members of the intermediate filament protein family. Mammalian lamins are classified into two major types, A and B, with two subspecies of each: lamins A and C for the A type and B1 and B2 for the B type. Lamins A and C arise from one gene by alternative splicing. Pre-lamin A contains a carboxyl CAAX box that can be modified by farnesylation. During mitosis, the lamina meshwork is reversibly disassembled in parallel with phosphorylation of the lamins.
C13810	Lymphoid	Anatomy_Modifier	Lymphoid|LYMOID|lymphoid	(LIM-foyd) Referring to lymphocytes, a type of white blood cell. Also refers to tissue in which lymphocytes develop.
C13811	Nucleosome_Core_Particle	Nuclear_Structure	Nucleosome Core Particle|Core Particle|Nucleosome Core	Nucleosome core particle consists of the 146 base pair highly protected DNA segment and its bound histone octamer (two of each histones H2A, histone2B,, H3 and H4). Nucleosome core particle, linker DNA and histone H1 comprise one structural unit of chromatin, nucleosome. (NCI)
C13812	Scaffold-Associated_Region	Chromosome_Structure	Scaffold-Associated Region	Regions of chromosomal DNA attached to structural components of metaphase (condensed) chromosomes, permitting the partitioning of DNA in the chromosomes into looped domains.  Appear to be related to similar regions denoted matrix-attachment regions that partition the chromosomal DNA in interphase chromosomes.
C13813	_3q21-q24	Chromosome_Band	3q21-q24	A chromosome band present on 3q
C13814	_1p22-p21	Chromosome_Band	1p22-p21	A chromosome band present on 1p
C13815	_8p21-p12	Chromosome_Band	8p21-p12	A chromosome band present on 8p
C13816	_13q14	Chromosome_Band	13q14	A chromosome band present on 13q
C13817	_11p15_1-p14	Chromosome_Band	11p15.1-p14	A chromosome band present on 11p
C13818	_14q24_1	Chromosome_Band	14q24.1	A chromosome band present on 14q
C13819	Somatosensory_Receptor	Sensory-Somatic_Nervous_System	Somatosensory Receptor	Nerve endings encased in connective tissue capsules with myelinated or unmyelinated axons.
C13820	_2q33_1	Chromosome_Band	2q33.1	A chromosome band present on 2q
C13821	Mechanoreceptor	Somatosensory_Receptor	Mechanoreceptor|Mechanoreceptors
C13822	Thermoreceptor	Somatosensory_Receptor	Thermoreceptor|Thermoreceptors
C13823	Proprioceptor	Somatosensory_Receptor	Proprioceptor|Proprioceptive Sensory Neuron
C13824	Muscle_Spindle	Musculoskeletal_System_Part	Muscle Spindle|Muscle Spindles	The Muscle Spindle is composed of intrafusal fibers that are located within and run parallel to the extrafusal fibers of skeletal muscle. When the extrafusal fibers are stretched, the intrafusal fibers of the spindle stretch as well. When stretching occurs, the sensory neuron from the muscle spindle signals the motor neurons located within the ventral horn of the spinal cord. This signal causes the motor neurons to fire, resulting in contraction of the muscle. This reflex arc provides negative feedback. The muscular contraction induced by the stretching works against or negates further muscle stretch. This mechanism helps to maintain proper muscle tension or tone. Although the muscle spindle helps to maintain proper muscle tension, unlike the Golgi tendon organ, it is not an indicator of muscle tension, but rather of muscle length.
C13825	_16p12	Chromosome_Band	16p12	A chromosome band present on 16p
C13826	Golgi_Tendon_Organ	Peripheral_Nervous_System_Part	Golgi Tendon Organ|Golgi's Tendon Organ|Golgi's Tendon Spindle|Neurotendinous Organ|Neurotendinous Spindle	The Golgi Tendon Organ is located within the tendons found on each end of a muscle. It responds to increased muscle tension or contraction as exerted on the tendon, by inhibiting further muscle contraction, which protects against muscle damage. The proprioceptive sensory neuron of a Golgi tendon organ, projects to the motor neurons located within the ventral horn of the spinal cord, where the inhibition occurs. Unlike the muscle spindle, Golgi tendon organs do not indicate muscle length, but rather muscle tension.
C13827	_2p23_3	Chromosome_Band	2p23.3	A chromosome band present on 2p
C13828	_9q34_3	Chromosome_Band	9q34.3	A chromosome band present on 9q
C13829	_5q13	Chromosome_Band	5q13	A chromosome band present on 5q
C13830	_8p11_23	Chromosome_Band	8p11.23	A chromosome band present on 8p
C13831	_5p13_3	Chromosome_Band	5p13.3	A chromosome band present on 5p
C13832	_9p22_2	Chromosome_Band	9p22.2	A chromosome band present on 9p
C13833	_17q12	Chromosome_Band	17q12	A chromosome band present on 17q
C13834	_17q12-q21_1	Chromosome_Band	17q12-q21.1	A chromosome band present on 17q
C13835	_6q22_33-q24_1	Chromosome_Band	6q22.33-q24.1	A chromosome band present on 6q
C13836	_11q14	Chromosome_Band	11q14	A chromosome band present on 11q
C13837	_19p13_12	Chromosome_Band	19p13.12	A chromosome band present on 19p
C13838	_5q33_2	Chromosome_Band	5q33.2	A chromosome band present on 5q
C13839	_11q24	Chromosome_Band	11q24	A chromosome band present on 11q
C13840	_8p22-p11	Chromosome_Band	8p22-p11	A chromosome band present on 8p
C13841	_8q13_1	Chromosome_Band	8q13.1	A chromosome band present on 8q
C13842	_4q12	Chromosome_Band	4q12	A chromosome band present on 4q
C13843	_20q12	Chromosome_Band	20q12	A chromosome band present on 20q
C13844	_20q12-q13_12	Chromosome_Band	20q12-q13.12	A chromosome band present on 20q
C13845	_20q11_1	Chromosome_Band	20q11.1	A chromosome band present on 20q
C13846	_21q11_2	Chromosome_Band	21q11.2	A chromosome band present on 21q
C13847	_1p36_1	Chromosome_Band	1p36.1	A chromosome band present on 1p
C13848	_12q13_1	Chromosome_Band	12q13.1	A chromosome band present on 12q
C13849	_7p14-p13	Chromosome_Band	7p14-p13	A chromosome band present on 7p
C13850	_2q34-q35	Chromosome_Band	2q34-q35	A chromosome band present on 2q
C13851	_6p25	Chromosome_Band	6p25	A chromosome band present on 6p
C13852	_16q24_2-q24_3	Chromosome_Band	16q24.2-q24.3	A chromosome band present on 16q
C13853	_1p33-p31	Chromosome_Band	1p33-p31	A chromosome band present on 1p
C13854	_5q35_1-qter	Chromosome_Band	5q35.1-qter	A chromosome band present on 5q
C13855	_11p15_2-p14_3	Chromosome_Band	11p15.2-p14.3	A chromosome band present on 11p
C13856	_1p31	Chromosome_Band	1p31	A chromosome band present on 1p
C13857	_17q24	Chromosome_Band	17q24	A chromosome band present on 17q
C13858	_16q23_1	Chromosome_Band	16q23.1	A chromosome band present on 16q
C13859	_20q13_2	Chromosome_Band	20q13.2	A chromosome band present on 20q
C13860	_1p21-p13_3	Chromosome_Band	1p21-p13.3	A chromosome band present on 1p
C13861	_7q11_1	Chromosome_Band	7q11.1	A chromosome band present on 7q
C13862	_17q23	Chromosome_Band	17q23	A chromosome band present on 17q
C13863	_20q13_13	Chromosome_Band	20q13.13	A chromosome band present on 20q
C13864	_2p16_3	Chromosome_Band	2p16.3	A chromosome band present on 2p
C13865	_10q22-q23	Chromosome_Band	10q22-q23	A chromosome band present on 10q
C13866	_14q31_1	Chromosome_Band	14q31.1	A chromosome band present on 14q
C13867	_15q21_2	Chromosome_Band	15q21.2	A chromosome band present on 15q
C13868	_13q21	Chromosome_Band	13q21	A chromosome band present on 13q
C13869	_10q11-p12	Chromosome_Band	10q11-p12	A chromosome band present on 10q
C13870	_11q13_1-q13_2	Chromosome_Band	11q13.1-q13.2	A chromosome band present on 11q
C13871	_8p22-p21_3	Chromosome_Band	8p22-p21.3	A chromosome band present on 8p
C13872	_13q13_3	Chromosome_Band	13q13.3	A chromosome band present on 13q
C13873	_5q13_1	Chromosome_Band	5q13.1	A chromosome band present on 5q
C13874	_5q12-q13	Chromosome_Band	5q12-q13	A chromosome band present on 5q
C13875	Xp11_21-p11_22	Chromosome_Band	Xp11.21-p11.22	A chromosome band present on Xp
C13876	_11q13_1	Chromosome_Band	11q13.1	A chromosome band present on 11q
C13877	_17p13_2	Chromosome_Band	17p13.2	A chromosome band present on 17p
C13878	_22q13_2-q13_31	Chromosome_Band	22q13.2-q13.31	A chromosome band present on 22q
C13879	_1p31-p22	Chromosome_Band	1p31-p22	A chromosome band present on 1p
C13880	_2p21	Chromosome_Band	2p21	A chromosome band present on 2p
C13881	_1q32	Chromosome_Band	1q32	A chromosome band present on 1q
C13882	_17q11-q21_3	Chromosome_Band	17q11-q21.3	A chromosome band present on 17q
C13883	_15q22_2	Chromosome_Band	15q22.2	A chromosome band present on 15q
C13884	_20pter-q12	Chromosome_Band	20pter-q12	A chromosome band present on 20p
C13885	_1q42_1-q43	Chromosome_Band	1q42.1-q43	A chromosome band present on 1q
C13886	_22q11_23	Chromosome_Band	22q11.23	A chromosome band present on 22q
C13887	_1p35	Chromosome_Band	1p35	A chromosome band present on 1p
C13888	_4q22	Chromosome_Band	4q22	A chromosome band present on 4q
C13889	_16q12	Chromosome_Band	16q12	A chromosome band present on 16q
C13890	_17q22-q23	Chromosome_Band	17q22-q23	A chromosome band present on 17q
C13891	_1q21	Chromosome_Band	1q21	A chromosome band present on 1q
C13892	_10q23_2-q23_3	Chromosome_Band	10q23.2-q23.3	A chromosome band present on 10q
C13893	_8p11	Chromosome_Band	8p11	A chromosome band present on 8p
C13894	_11p15_2-p15_1	Chromosome_Band	11p15.2-p15.1	A chromosome band present on 11p
C13895	_7p21_3	Chromosome_Band	7p21.3	A chromosome band present on 7p
C13896	_12p13_32	Chromosome_Band	12p13.32	A chromosome band present on 12p
C13897	_16p13_12	Chromosome_Band	16p13.12	A chromosome band present on 16p
C13898	_20q12-q13_2	Chromosome_Band	20q12-q13.2	A chromosome band present on 20q
C13899	_1q32_2	Chromosome_Band	1q32.2	A chromosome band present on 1q
C13900	_19p13_2-p12	Chromosome_Band	19p13.2-p12	A chromosome band present on 19p
C13901	_17q11_2-q21_1	Chromosome_Band	17q11.2-q21.1	A chromosome band present on 17q
C13902	_17q23_1	Chromosome_Band	17q23.1	A chromosome band present on 17q
C13903	_8q24_1-q24_3	Chromosome_Band	8q24.1-q24.3	A chromosome band present on 8q
C13904	_14q24	Chromosome_Band	14q24	A chromosome band present on 14q
C13905	_14q11_2-q12	Chromosome_Band	14q11.2-q12	A chromosome band present on 14q
C13906	BIR_Domain	Protein_Binding_Domain	BIR Domain|BIR Motif|Baculovirus Inhibitor of Apoptosis Protein Repeat|IAP Repeat|Inhibitor of Apoptosis Domain	Containing perfectly conserved histidine and cysteines residues. the BIR domain is about 70 residues long arranged in tandem repeats separated by a linker of variable length. Found in IAP (Inhibitor of Apoptosis Protein) Family proteins, it seems to confer cell death-preventing activity. Except NAIP, family members typically contain two or three BIR repeats and a C-terminal RING finger. A second group of BIR-domain-containing proteins (BIRPs) include mammalian Bruce and Survivin proteins, as well as BIR-containing proteins in yeasts and C. elegans. Survivin-like BIRPs regulate cytokinesis and mitotic spindle formation. (NCI)
C13907	UBC_Domain	Protein_Binding_Domain	UBC Domain|Ubiquitin-Conjugating Domain	The 16-kD UBC domain contains a conserved UBC motif and a conserved cysteine that accepts activated ubiquitin from E1 enzyme to form a thiol ester. Basic residues at the UBC domain N-terminus may be involved in E1 binding. UBC/E2 enzymes catalyze ubiquitination of target proteins with or without E3 'N-end' recognizing proteins. E2s can be classified on the basis of UBC structure. Poor at transferring ubiquitin to proteins on their own, Class I proteins comprise simply the UBC domain and probably require an E3 to ubiquitinate short-lived abnormal proteins prior to degradation. Class II enzymes contain different acidic C-terminal extensions of the UBC domain that appear to involve cellular localization or to mediate interaction with protein substrates for ubiquitination that results in protein modification but not degradation. Class III E2s have N-terminal extensions, but their function is unknown. (NCI)
C13908	_22q13_3	Chromosome_Band	22q13.3	A chromosome band present on 22q
C13909	_2q12_3	Chromosome_Band	2q12.3	A chromosome band present on 2q
C13910	_12q24_21	Chromosome_Band	12q24.21	A chromosome band present on 12q
C13911	Bcl-2_Homology_Domain	Protein_Binding_Domain	Bcl-2 Homology Domain	Proteins that are related to bcl-2 are characterized by the presence of one or more highly conserved stretches of homology with bcl-2, designated BH1, BH2, BH3, BH4. These domains control the ability of these proteins to homo- and heterodimerize with other proteins. Competitive dimerization between family members is thought to regulate their function as regulators of apoptosis.
C13912	BH1_Domain	Bcl-2_Homology_Domain	BH1 Domain|BCL-2 Homology 1 Domain	Found in proteins that regulate apoptosis, conserved a-helix BCL-2 Homology (BH1-4) Domains are critical to protein apoptotic function and the protein ability to interact/dimerize with other family members or regulatory proteins. BH1 contains predominantly hydrophobic residues. BCL-2 family proteins dimerize among pro- and anti-apoptotic class family members. BCL-2 homodimerization appears to involve head-to-tail interaction of N-terminal BH4 resides with more distal BH1, BH2, and BH3 regions. BCL-2/BAX heterodimerization appears to involve tail-to-tail interaction of the BCL-2 BH1, BH2, and BH3 regions and the BAX BH3 domain region. BCL-2 may suppress cell death partly by binding to BAX via the BH3 domain preventing BAX homodimer formation. (NCI)
C13913	BH2_Domain	Bcl-2_Homology_Domain	BH2 Domain|BCL-2 Homology 2 Domain	Found in proteins that regulate apoptosis, conserved a-helix BCL-2 Homology (BH1-4) Domains are critical to protein apoptotic function and the protein ability to interact/dimerize with other family members or regulatory proteins. BCL-2 family proteins dimerize among pro- and anti-apoptotic class family members. BCL-2 homodimerization appears to involve head-to-tail interaction of N-terminal BH4 resides with more distal BH1, BH2, and BH3 regions. BCL-2/BAX heterodimerization appears to involve tail-to-tail interaction of the BCL-2 BH1, BH2, and BH3 regions and the BAX BH3 domain region. BCL-2 may suppress cell death partly by binding to BAX via the BH3 domain preventing BAX homodimer formation. (NCI)
C13914	BH3_Domain	Bcl-2_Homology_Domain	BH3 Domain	The alpha-helical BH3 domain (9 amino acids) represents a minimal death domain and is essential for the activity of pro-apoptotic members of the bcl-2 family. Some of these proteins only contain a BH3 domain.
C13915	BH4_Domain	Bcl-2_Homology_Domain	BH4 Domain	BH4 is present only in the amino-terminal regions of pro-survival family bcl-2 members and is essential for the anti-apoptotic function, although deletion of BH4 does not necessarily impair the ability of BH4-containing proteins to bind to a variety of other bcl-2-related proteins.
C13916	_11q22	Chromosome_Band	11q22	A chromosome band present on 11q
C13917	_2p11	Chromosome_Band	2p11	A chromosome band present on 2p
C13918	_4q28-q31	Chromosome_Band	4q28-q31	A chromosome band present on 4q
C13919	_8q21_13	Chromosome_Band	8q21.13	A chromosome band present on 8q
C13920	_2q21-q22	Chromosome_Band	2q21-q22	A chromosome band present on 2q
C13922	WAP_Domain	Disulfide_Linkage|Protein_Binding_Domain	WAP Domain|WAP Motif|Whey Acidic Protein Domain	The WAP (Whey Acidic Protein) Domain contains eight characteristically-spaced cysteine residues involved in disulphide bond formation and occurs in so-called 'four-disulphide core' proteins. The spatial pattern of these conserved domain cysteines suggests that the otherwise variable domain sequences may adopt a similar fold. The overall degree of domain sequence similarity is low; a few Pro and Gly residues are reasonably well conserved, as are polar/acidic residues between Cys3 and Cys4. WAP sequences are found in Whey Acidic Protein; Elafin (a human skin elastase-specific inhibitor); rat WDNM1 Protein (involved in metastatic potential); Kallmann Syndrome Protein; and guinea pig Caltrin-Like Protein II (inhibits calcium transport into spermatozoa). (NCI)
C13923	_3p22-p21_3	Chromosome_Band	3p22-p21.3	A chromosome band present on 3p
C13924	_3q13_1-q13_2	Chromosome_Band	3q13.1-q13.2	A chromosome band present on 3q
C13925	_11pter-p13	Chromosome_Band	11pter-p13	A chromosome band present on 11p
C13926	_11q23_1	Chromosome_Band	11q23.1	A chromosome band present on 11q
C13927	_17q23-q25	Chromosome_Band	17q23-q25	A chromosome band present on 17q
C13928	Non-Neural_Epithelial_Tissues	Retired_Concepts	Non-Neural Epithelial Tissues
C13929	Cadherin_Domain	Protein_Binding_Domain	Cadherin Domain	Evolutionary related to desmosomal desmogleins, cadherins contain a signal sequence, a propeptide of around 130 residues, an extracellular domain of around 600 residues, a single transmembrane domain, and a well-conserved C-terminal cytoplasmic domain of about 150 residues. The extracellular domain typically consists of four Cadherin Domain repeats of about 110 residues; an adjacent fifth domain contains four conserved cysteines. The domain includes conserved Asp and Arg residues that may be involved in calcium binding. Tissue-specific cadherin glycoproteins are responsible for homophilic calcium-dependent cell-cell adhesion likely involved in cell type sorting during morphogenesis, histogenesis, and regeneration. They may also regulate tight and gap junctions. (NCI)
C13930	_16p11_2	Chromosome_Band	16p11.2	A chromosome band present on 16p
C13931	_9q33	Chromosome_Band	9q33	A chromosome band present on 9q
C13932	_12q22	Chromosome_Band	12q22	A chromosome band present on 12q
C13933	_9q32	Chromosome_Band	9q32	A chromosome band present on 9q
C13934	Xq26	Chromosome_Band	Xq26	A chromosome band present on Xq
C13935	_1q23	Chromosome_Band	1q23	A chromosome band present on 1q
C13936	_1q25	Chromosome_Band	1q25	A chromosome band present on 1q
C13937	EGF-Like_Domain	Protein_Domain	EGF-Like Domain	A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF) has been shown to be present, in a conserved form, in a large number of other, mostly animal proteins. The list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied. The functional significance of EGF domains in what appear to be unrelated proteins is not yet clear. However, a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in disulfide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet. Subdomains between the conserved cysteines vary in length. (InterPro IPR006209)
C13938	Disintegrin_Domain	Ligand_Binding_Domain	Disintegrin Domain	It is an integrin binding domain originally identified in ADAM family proteins. (NCI)
C13939	_17q11-q12	Chromosome_Band	17q11-q12	A chromosome band present on 17q
C13940	_9p11_2	Chromosome_Band	9p11.2	A chromosome band present on 9p
C13941	_14q32	Chromosome_Band	14q32	A chromosome band present on 14q
C13942	_17p13-p12	Chromosome_Band	17p13-p12	A chromosome band present on 17p
C13943	_7q31_1	Chromosome_Band	7q31.1	A chromosome band present on 7q
C13944	_8q21	Chromosome_Band	8q21	A chromosome band present on 8q
C13945	FHA_Domain	Protein_Domain	FHA Domain|Forkhead-Associated Domain	The FHA (Forkhead-Associated) domain is a phosphopeptide recognition domain found in many regulatory proteins. It displays specificity for phosphothreonine-containing epitopes but will also recognize phosphotyrosine with relatively high affinity. It spans approximately 80-100 amino acid residues folded into an 11-stranded sandwich, which sometimes contain small helical insertions between the loops connecting the strands. To date, genes encoding FHA-containing proteins have been identified in eubacterial and eukaryotic but not aracheal genomes. The domain is present in a diverse range of proteins, such as kinases, phosphatases, kinesins, transcription factors, RNA-binding proteins and metabolic enzymes which partake in many different cellular processes. DNA repair, signal transduction, vesicular transport and protein degradation are just a few examples. (From Pfam PF00498)
C13946	Breast_Cancer_Carboxy-Terminal_Domain	Retired_Concepts	Breast Cancer Carboxy-Terminal Domain
C13947	_1p36_11	Chromosome_Band	1p36.11	A chromosome band present on 1p
C13948	_12p11_1	Chromosome_Band	12p11.1	A chromosome band present on 12p
C13949	_4q32_2	Chromosome_Band	4q32.2	A chromosome band present on 4q
C13950	Nucleoplasm	Cell_Part	Nucleoplasm	The nuclear contents other than the nucleolus. (from On-line Medical Dictionary)
C13951	Nuclear_Pore_Complex	Cell_Part	Nuclear Pore Complex|NPC	Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC). NPC is comprised of approximately 50 unique proteins collectively known as nucleoporins. NPC functions in the nuclear transport of protein and RNA. (NCI)
C13952	_5q35	Chromosome_Band	5q35	A chromosome band present on 5q
C13953	_20pter-p12	Chromosome_Band	20pter-p12	A chromosome band present on 20p
C13954	_2q35-q36	Chromosome_Band	2q35-q36	A chromosome band present on 2q
C13955	Desmosome	Anchoring_Junction	Desmosome|Desmosomes|Macula Adherens|Spot Desmosome	Desmosomes are intercellular anchoring junctions that anchor intermediate filaments at membrane-associated plaques in adjoining cells.  Desmosomes assemble in response to cell-cell contact and raised levels of extracellular calcium. Sensitivity to calcium levels is lost as desmosomes mature.(NCI)
C13956	EF-Hand_Domain	Calcium-Binding_Domain	EF-Hand Domain|EF-Hand Calcium-Binding Motif	Forming a single Ca2+-binding site in many calcium-binding proteins, the basic EF-Hand Domain consists of a conserved 12-residue loop region between two perpendicular 10-12 residue alpha helices (helix-loop-helix). Ca2+ interacts with loop residues in a pentagonal bipyramidal configuration; each loop residue is important for Ca2+ coordination. Loop residues 1, 3, 5, 7, 9, and 12 (invariant Glu or Asp) are directly necessary for Ca2+ binding. Amino-acid variations at positions 1, 3, 5, 7, and 9 alter ion affinity. Single or multiple domains cause structural/functional variations. EF-hand Proteins are grouped into either regulatory/signaling or structural/buffering/transport categories. Ca2+ binding to regulatory proteins induces conformational/functional change; Ca2+ binding to structural proteins seems to provide a Ca2+ buffer. (NCI)
C13957	_1q43-q44	Chromosome_Band	1q43-q44	A chromosome band present on 1q
C13958	_3q26_3	Chromosome_Band	3q26.3	A chromosome band present on 3q
C13959	_4q13_3-q21_1	Chromosome_Band	4q13.3-q21.1	A chromosome band present on 4q
C13960	SAM_Domain	Protein_Binding_Domain	SAM Domain|Sterile Alpha Motif|Sterile Alpha Motif Domain	The approximately 70 amino acid SAM (Sterile Alpha Motif) domain has been identified in over 400 different proteins with diverse cellular function, from yeast to man. SAM domains have been implicated in mediating protein-protein interaction via the formation of homo and hetero-typic oligomers. The residues at the interface of the EphA4 and EphB2 SAM domain homodimers have been mapped, but the factors that determine specificity remain to be determined. (Pawson Lab, SLRI, Mount Sinai Hospital, 2003)
C13961	_15q22_1-q22_33	Chromosome_Band	15q22.1-q22.33	A chromosome band present on 15q
C13962	_6p24_3	Chromosome_Band	6p24.3	A chromosome band present on 6p
C13963	_16p12-p11_2	Chromosome_Band	16p12-p11.2	A chromosome band present on 16p
C13964	_10q21_1	Chromosome_Band	10q21.1	A chromosome band present on 10q
C13965	Trefoil_Motif	Protein_Domain	Trefoil Motif|P Domain|P-Type Domain|TFF Domain	Domain found in various secretory polypeptides that has highly conserved cysteine residues that are disulfide bonded in such a way as to generate a trefoil structure (bonded 1-5, 2-4, 3-6). There are also highly conserved A, G and W residues. (The Dictionary of Cell and Molecular Biology - Online)
C13966	_18p11_32	Chromosome_Band	18p11.32	A chromosome band present on 18p
C13967	Coiled-Coil_Domain	Protein_Domain	Coiled-Coil Domain|4-3 Hydrophobic Repeat|Left-Handed Twist	The coiled-coil domain stabilizes alpha helices in proteins, through a very efficient burial of hydrophobic side chains so that polar water molecules do not access them. As a result, the helices are quite stable. In fact, many structural proteins (keratins, tropomyosin, laminin) that have to bear considerable stress have a coiled-coil domain. Two basic essential features are common: (1) the overall secondary structure is alpha helical, (2) the hydrophobic residues are arranged on one side of the helices. The typical positioning of the hydrophobic residues in the coiled-coil domain can be often recognized from primary structure of the protein. The helices can be parallel or antiparallel. The former is common when the helices belong to different polypeptides and the latter prevails in coiled coils made up from a single polypeptide chain. The number of helices in the coil varies usually between 2 and 4. (From http://www.cryst.bbk.ac.uk)
C13968	_8p23_1	Chromosome_Band	8p23.1	A chromosome band present on 8p
C13969	_9p23	Chromosome_Band	9p23	A chromosome band present on 9p
C13970	_26S_ATP-Dependent_Proteasome	Proteasome	26S ATP-Dependent Proteasome|26S ATP-Dependent Protease|26S Proteasome Complex|26S Proteosome	Proteasomes are large multicatalytic proteolytic complexes found in all eukaryotic cells, and simpler forms have been found in archaebacteria and certain eubacteria.  In eukaryotes, the 20S proteasome also exists as the central core of the 26S (2000 kDa) proteasome complex, which catalyzes the degradation of ubiquitin-conjugated proteins and contains an additional 19S complex, composed of regulatory proteins and six ATPases.
C13971	_8q21-q24	Chromosome_Band	8q21-q24	A chromosome band present on 8q
C13972	_2p14-p13	Chromosome_Band	2p14-p13	A chromosome band present on 2p
C13973	_1q32-q41	Chromosome_Band	1q32-q41	A chromosome band present on 1q
C13974	TRIM_Motif	Metal_Binding_Site	TRIM Motif|RBCC/TRIM Motif|Tripartite Motif	The TRIM motif includes three cysteine-rich zinc-binding domains, a RING finger, a B-box, and a coiled-coil region. The order of the sub-domains is conserved, with the RING finger, B-box and coiled -coil domains arranged from the N to C-terminus. However, the number of B-boxes can vary. (NCI)
C13975	RSXpSXP_Motif	Protein_Binding_Domain	RSXpSXP Motif	The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. RSXpSXP Motif is one of two different binding motifs that are present in nearly all known 14-3-3 binding proteins. The14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. (from OMIM)
C13976	RXY_FXpSXP_Motif	Protein_Binding_Domain	RXY/FXpSXP Motif	The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. RXY/FXpSXP Motif is one of two different binding motifs that are present in nearly all known 14-3-3 binding proteins. The14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. (from OMIM)
C13977	Phosphoserine_Motif	Protein_Domain	Phosphoserine Motif
C13978	_14q21-q22	Chromosome_Band	14q21-q22	A chromosome band present on 14q
C13979	_1q22-q25	Chromosome_Band	1q22-q25	A chromosome band present on 1q
C13980	_1q23-q25	Chromosome_Band	1q23-q25	A chromosome band present on 1q
C13981	_17q11	Chromosome_Band	17q11	A chromosome band present on 17q
C13982	_12q11-q14	Chromosome_Band	12q11-q14	A chromosome band present on 12q
C13983	Cell_Junction	Cell_Part	Cell Junction	Cell junction is the specialized focal contact between cell-cell or cell-matrix in all tissues.  Cell junctions have various functions either communication, anchoring or organization.  There are specific protein associated with subtype of cell junctions and most of the junctions are too small to be resolved by light microscope.
C13984	Anchoring_Junction	Epithelial_Cell_Junction	Anchoring Junction|Adhering Junction|Adhesive Junction	Anchoring junctions typically are observed as "spot welds" between cells in many types of epithelia. Detail structures can be seen only with EM. (NCI)
C13985	Fascia_Adherens	Anchoring_Junction	Fascia Adherens	Fascia adherens, similar to a zonula adherens, is a half Z line found in the cardiac muscle as one of the three intercalated disks.  They anchor actin filaments from terminal sarcomeres and transmit contractile force between myocytes. (NCI)
C13986	_10q24-q26	Chromosome_Band	10q24-q26	A chromosome band present on 10q
C13987	_2p13-q13	Chromosome_Band	2p13-q13	A chromosome band present on 2p
C13988	_5q31_1	Chromosome_Band	5q31.1	A chromosome band present on 5q
C13989	_13q14_3	Chromosome_Band	13q14.3	A chromosome band present on 13q
C13990	_10q22_1-q23	Chromosome_Band	10q22.1-q23	A chromosome band present on 10q
C13991	_5q32-q34	Chromosome_Band	5q32-q34	A chromosome band present on 5q
C13992	_2q33-q36	Chromosome_Band	2q33-q36	A chromosome band present on 2q
C13993	_1p35-p31_3	Chromosome_Band	1p35-p31.3	A chromosome band present on 1p
C13994	_12q22-q23	Chromosome_Band	12q22-q23	A chromosome band present on 12q
C13995	_9q22_32	Chromosome_Band	9q22.32	A chromosome band present on 9q
C13996	_7q22	Chromosome_Band	7q22	A chromosome band present on 7q
C13997	_7q21-q22	Chromosome_Band	7q21-q22	A chromosome band present on 7q
C13998	_6q24-q25	Chromosome_Band	6q24-q25	A chromosome band present on 6q
C13999	_15q24-q25	Chromosome_Band	15q24-q25	A chromosome band present on 15q
C14000	_15q21_1-q21_2	Chromosome_Band	15q21.1-q21.2	A chromosome band present on 15q
C14001	_1p35_1-p36_23	Chromosome_Band	1p35.1-p36.23	A chromosome band present on 1p
C14002	_8q22_3-q23	Chromosome_Band	8q22.3-q23	A chromosome band present on 8q
C14003	_4q26-q32	Chromosome_Band	4q26-q32	A chromosome band present on 4q
C14004	_3p21_1	Chromosome_Band	3p21.1	A chromosome band present on 3p
C14005	_2p12	Chromosome_Band	2p12	A chromosome band present on 2p
C14006	_4p13	Chromosome_Band	4p13	A chromosome band present on 4p
C14007	_2p13_1	Chromosome_Band	2p13.1	A chromosome band present on 2p
C14008	_20p12	Chromosome_Band	20p12	A chromosome band present on 20p
C14009	_4p14-q21	Chromosome_Band	4p14-q21	A chromosome band present on 4p
C14010	_6p11_1	Chromosome_Band	6p11.1	A chromosome band present on 6p
C14011	_6p24-p23	Chromosome_Band	6p24-p23	A chromosome band present on 6p
C14012	_1p35-p32	Chromosome_Band	1p35-p32	A chromosome band present on 1p
C14013	_12pter-p12	Chromosome_Band	12pter-p12	A chromosome band present on 12p
C14014	_3q13_3-q21	Chromosome_Band	3q13.3-q21	A chromosome band present on 3q
C14015	_10q22_3	Chromosome_Band	10q22.3	A chromosome band present on 10q
C14016	_2q33-q34	Chromosome_Band	2q33-q34	A chromosome band present on 2q
C14017	Xp22_2	Chromosome_Band	Xp22.2	A chromosome band present on Xp
C14018	_8p21	Chromosome_Band	8p21	A chromosome band present on 8p
C14019	_21q21_2	Chromosome_Band	21q21.2	A chromosome band present on 21q
C14020	_3p14_3-p14_2	Chromosome_Band	3p14.3-p14.2	A chromosome band present on 3p
C14021	_4q13_1	Chromosome_Band	4q13.1	A chromosome band present on 4q
C14022	_22q12_1	Chromosome_Band	22q12.1	A chromosome band present on 22q
C14023	Xq22-q23	Chromosome_Band	Xq22-q23	A chromosome band present on Xq
C14024	_1q22	Chromosome_Band	1q22	A chromosome band present on 1q
C14025	_13p12	Chromosome_Band	13p12	A chromosome band present on 13p
C14026	_8q24_3	Chromosome_Band	8q24.3	A chromosome band present on 8q
C14027	_4p16	Chromosome_Band	4p16	A chromosome band present on 4p
C14028	_19q12	Chromosome_Band	19q12	A chromosome band present on 19q
C14029	_15q15_2	Chromosome_Band	15q15.2	A chromosome band present on 15q
C14030	_20q13_2-q13_3	Chromosome_Band	20q13.2-q13.3	A chromosome band present on 20q
C14031	_4q34_1-q34_3	Chromosome_Band	4q34.1-q34.3	A chromosome band present on 4q
C14032	_6q26-q27	Chromosome_Band	6q26-q27	A chromosome band present on 6q
C14033	_4p16_3	Chromosome_Band	4p16.3	A chromosome band present on 4p
C14034	_20q12-q13_1	Chromosome_Band	20q12-q13.1	A chromosome band present on 20q
C14035	Xp11_22	Chromosome_Band	Xp11.22	A chromosome band present on Xp
C14036	_11q13_5	Chromosome_Band	11q13.5	A chromosome band present on 11q
C14037	_1q42	Chromosome_Band	1q42	A chromosome band present on 1q
C14038	_19p13_11	Chromosome_Band	19p13.11	A chromosome band present on 19p
C14039	_3p21_3-p21_1	Chromosome_Band	3p21.3-p21.1	A chromosome band present on 3p
C14040	_2p22_3-p21	Chromosome_Band	2p22.3-p21	A chromosome band present on 2p
C14041	_19q13_3	Chromosome_Band	19q13.3	A chromosome band present on 19q
C14042	BRCT_Domain	Protein_Binding_Domain	BRCT Domain|Breast Cancer Carboxy-Terminal Domain	BRCT domain was first identified in C-terminal domain of breast cancer associated protein and was found in many proteins that regulate the cellular response to DNA repair, where these domains act as multi-purpose protein-protein interaction modules. Crystallography study reveals that two ~95 amino acid BRCT repeats within the domain adopt similar structures that pack together in a head-to-tail arrangement. (NCI)
C14043	Walker-A_Motif	Protein_Domain	Walker-A Motif	The ATP binding cassette (ABC) is the largest protein family known and many of its members are membrane proteins (ABC transporters) active in the transport of a wide variety of substances across membranes. ABC proteins are identified by the presence of one or two cytosolically oriented ATP-binding cassettes or nucleotide-binding domains (NBD) of about 200 amino acid residues. Each NBD contains three typical motifs: the Walker A motif, GX4GK(ST), the Walker B motif and the ABC signature or C motif. Walker A and B motifs are found in other nucleotide-binding proteins, including P-, F- and V-ATPases, G proteins, adenylate kinase, myosin, phosphofructokinase and ATP/ADP exchangers. Although the overall similarity between ABC proteins can be very low, their NBDs share an average of 30-40 % similarity. (From http://www.arabidopsisabc.net/intro.asp)
C14044	PWWP_Domain	Protein_Binding_Domain	PWWP Domain	Around 70 amino acids and weakly conserved, the PWWP Domain is named after a conserved Pro-Trp-Trp-Pro motif often found as multiple copies in proteins that contain chromatin-association domains or in cell growth and differentiation transcription factors, such as WHSC1 (C-terminus) and ASH1/Trithorax Group proteins. Although its function is unknown, the amino acid composition suggests that it may be involved in protein-protein interactions. The domain N-terminal half resembles a barrel-like five-stranded structure; the C-terminal half contains a five-helix bundle. The halves form a module that exhibits positive electrostatic potential. Alone, the domain binds DNA in vitro, probably through its basic surface. (NCI)
C14045	_3q13	Chromosome_Band	3q13	A chromosome band present on 3q
C14046	_5p15_1-p14	Chromosome_Band	5p15.1-p14	A chromosome band present on 5p
C14047	Immunoreceptor_Tyrosine-Based_Motif	Protein_Domain	Immunoreceptor Tyrosine-Based Motif
C14048	ITAM	Immunoreceptor_Tyrosine-Based_Motif	ITAM|ARAM|Ag Recognition Activation Motif|Immunoreceptor Tyr-Based Activation Motif|Immunoreceptor Tyrosine-Based Activation Motif	ITAM (Immunoreceptor Tyrosine-based Activation Motif) or ARAM (Ag Recognition Activation Motif) (Y-X-X-L-(X)6-8-Y-X-X-L), a protein domain involved in STP, binds to SH2 domain, e.g. in CD247/x chain, FceRI g chain, or DAP12. Phosphorylated immunoreceptor signaling motifs (ITAMs) exhibit unique abilities to bind and activate Lyn and Syk tyrosine kinases. Motif may be dually phosphorylated on tyrosine that links antigen receptors to downstream signaling machinery. (From Pfam PF0218 and http://digilander.libero.it/danielefocosi/proteindomains.html)
C14049	ITIM	Immunoreceptor_Tyrosine-Based_Motif	ITIM|Immunoreceptor Tyrosine-Based Inhibitory Motif	ITIM (immunoreceptor Tyr-based inhibition motif) (I/V-X-Y-X-X-L), a protein domain involved in STP, binds to SH2 domain in SHP1 and SHP2, e.g., in KIR family. (http://digilander.libero.it/danielefocosi/proteindomains.html)
C14050	Post-Translational_Modification_Site	Protein_Structure	Post-Translational Modification Site	A post-translational modification site refers to amino acid residues within a peptide that act as acceptors for any modifications that do not happen concurrent with translation.
C14051	N-Glycosylation_Site	Post-Translational_Modification_Site	N-Glycosylation Site	A glycosylation site is an amino acid residue within a peptide that accepts oligosaccharide via amide linkage, specifically through amide nitrogen of asparagine via N-acetylglucosamine, as one of the post-translational modifications.
C14052	Myristic_Acylation_Site	Post-Translational_Modification_Site	Myristic Acylation Site|Myristoylation Site	It refers to amino acid residue within a peptide that accepts covalent linkage of fatty acid, myristoyl group (C13H27-) as one of the co-translational modifications. N-myristoylation, catalyzed by N-myristoyltransferase, is the amide modification of proteins by the addition of a myristoyl group to an N-terminal glycine residue. (NCI)
C14053	Palmitic_Acylation_Site	Post-Translational_Modification_Site	Palmitic Acylation Site|Palmitoylation Site	It refers to amino acid residue within a peptide that accepts fatty acid, palmitoyl group (C15H31-)as one of the reversible post-translational modifications. Protein palmitoylation is a thioester bond between palmitoyl-CoA and cysteine thiol. (NCI)
C14054	Phosphorylation_Site	Post-Translational_Modification_Site	Phosphorylation Site	Generally refers to amino acids residues that were covalently modified by phosphate group (PO4-). (NCI)
C14055	YDYVHL_Motif	SH2-Binding_Motif|Tyrosine_Phosphorylation_Site	YDYVHL Motif	YDYVHL (tyrosine-aspartic acid-tyrosine-valine-histidine-leucine) is a preferred substrate sequence by focal adhesion kinase.  The phosphorylated YDYVHL containing protein recruits src family kinases, which can then phosphorylate other tyrosine residues within the peptide. (NCI)
C14056	Tyrosine_Phosphorylation_Site	Phosphorylation_Site	Tyrosine Phosphorylation Site	It refers to amino acid tyrosine residue that was covalently modified by phosphate group (PO4-). (NCI)
C14057	Serine_Phosphorylation_Site	Phosphorylation_Site	Serine Phosphorylation Site	It refers to amino acid serine residue that was covalently modified by phosphate group (PO4-). (NCI)
C14058	Threonine_Phosphorylation_Site	Phosphorylation_Site	Threonine Phosphorylation Site	It refers to amino acid threonine residue that was covalently modified by phosphate group (PO4-). (NCI)
C14059	YXXP_Motif	SH2-Binding_Motif|Tyrosine_Phosphorylation_Site	YXXP Motif	Typically found in SH2-Binding Motifs of signaling proteins, the YXXP Motif interacts with SH2 domains of partner proteins upon Y phosphorylation. SH2 domains of ~100 amino acids bind to specific phosphotyrosine (pY)-containing motifs with dissociation constants of ~50-500 nM. A conserved pocket of SH2 domains recognizes the pY; a more variable pocket binds residues C-terminal to pY that confer specificity. SH2 domains balance high affinity for pY and recognition of adjacent residues to allow specific discrimination. The SH2 domain, an anti-parallel b-sheet between a-helices, provides a positively charged b-sheet pocket for binding of pY moieties, and an extended b-sheet surface for binding residues C-terminal to pY. B-sheet surface differences have significant effects on ligand-specificity. (NCI)
C14060	PKC_Phosphorylation_Site	Phosphorylation_Site	PKC Phosphorylation Site	It refers to amino acid residues that can be the target for protein kinase C phosphorylation. (NCI)
C14061	Amphipathic_Alpha_Helix	Alpha_Helix	Amphipathic Alpha Helix	The amphipathic helix motif is characterized by a repeating pattern of polar (P) and non-polar (N) side-chains that can be summarized as PxNPPNx. These clusters varied in length from 6 to 15 residues. The conserved non-polar positions are marked by a distinct absence of Asp, Asn and Ser, while other polar side chains are sometimes allowed. (from http://isites.bio.rpi.edu/bystrc/Isites/amph_alpha.html)
C14062	Disulfide_Linkage	Post-Translational_Modification_Site	Disulfide Linkage|Disulfide Bond	A disulfide linkage is a covalent bond between 2 sulfide atoms from the thiol group of 2 cysteine residues (S-S). They occur both interstrand and intrastrand.
C14063	Globular_Region	Protein_Domain	Globular Region	A protein region consisting of a hydrophilic surface and a hydrophobic core.
C14064	Tertiary_Protein_Structure	Protein_Structure	Tertiary Protein Structure	Tertiary structure describes the folding of the polypeptide chain to assemble the different secondary structure elements in a particular arrangement.
C14065	Protein_Region	Retired_Concepts	Protein Region	An informal header for somewhat informal parts of a protein molecule.
C14066	_7q21_2-q22_1	Chromosome_Band	7q21.2-q22.1	A chromosome band present on 7q
C14067	_14q31	Chromosome_Band	14q31	A chromosome band present on 14q
C14068	Acidic_Region	Protein_Domain	Acidic Region	Any portion of a protein molecule with a net negative charge.
C14069	Cysteine-Rich_Domain	Protein_Domain	Cysteine-Rich Domain	The Cysteine-Rich Domain is usually found in two copies per protein. It contains up to four conserved cysteines. The family includes a subunit from heterodisulfide reductase and a subunit from glycolate oxidase and glycerol-3-phosphate dehydrogenase. (Pfam PF02754)
C14070	Cellular_Membrane	Cell_Structure	Cellular Membrane|Cell Membrane	Any of the lipid bilayer membranes within a cell.
C14071	NAD-Binding_Domain	Ligand_Binding_Domain	NAD-Binding Domain|NAD-Binding Fold	The Gly-rich NAD-Binding Domain (often N-terminal) is often found in metabolic enzymes involved in glycolysis, glyconeogenesis, and the citric acid cycle, such as GAPDH (glyceraldehyde-3-phosphate oxidation and phosphorylation), lactate dehydrogenases (lactate to pyruvate conversion), and malate dehydrogenases (malate to oxaloacetate interconversion). (NCI)
C14072	GXGXXXG_Motif	NAD-Binding_Domain	GXGXXXG Motif	The GXGXXXG Motif is often found it the NAD-binding domain (often N-terminal) in metabolic enzymes involved in glycolysis, glyconeogenesis, and the citric acid cycle, such as GAPDH (glyceraldehyde-3-phosphate oxidation and phosphorylation), lactate dehydrogenases (lactate to pyruvate conversion), and malate dehydrogenases (malate to oxaloacetate interconversion). (NCI)
C14073	Substrate_Domain	Ligand_Binding_Domain	Substrate Domain	A Substrate Domain is a protein region that physically interacts stereospecifically, and usually at high affinity, with a specific target substrate. In enzymes, the substrate domain is often, though not necessarily, coincident with the catalytic domain. Typically, substrate interaction results in some protein conformational alteration and functional modification. (NCI)
C14074	ATPase_Domain	Substrate_Domain	ATPase Domain	A protein domain that binds ATP and catalyzes its convertion to ADP and inorganic phosphate.
C14075	Tyrosine_Kinase_Domain	Substrate_Domain	Tyrosine Kinase Domain	A protein domain that binds a protein and catalyzes the covalent addition of a phosphate group specifically to a tyrosine residue.
C14076	DH_Domain	Protein_Domain	DH Domain|Dbl Homology Domain|RhoGEF Domain	The Dbl homology (DH) or RhoGEF domain consists of a 150 amino acid region that induces Rho family GTPases to displace GDP. This effectively activates the Rho GTPase by allowing binding to GTP, which is in excess over GDP in the cell. The DH domain is invariably proceeded by a pleckstrin homology (PH) domain. While not absolutely required for catalysis of nucleotide exchange, the PH domain appears to greatly increase catalytic efficiency in many cases. Rho proteins control actin dynamics, gene expression, membrane trafficking, growth factor signaling, and cellular transformation. Proteins encoding DH domains (RhoGEFs) also play a role in these events as they function as the primary activators of Rho GTPases. In fact, many RhoGEFs were identified based on their transforming activity, which was abrogated upon disruption of their DH domain. (Pawson Lab, SLRI, Mount Sinai Hospital, 2003)
C14077	PH_Domain	Protein_Domain	PH Domain|Pleckstrin Homology Domain|Pleckstrin-Homology Domain	PH domains are protein modules of approximately 120 amino acids found in a wide variety of signalling proteins in organisms ranging for yeast to humans. Some PH domains bind with high affinity (low mM or nM Kd) to specific phosphoinositides such as phosphatidyl-inositol (PI) -4,5-bisphosphate, PI-3,4-P2 or PI-3,4,5-P3. Binding to phosphoinositides may allow PH proteins to respond to lipid messengers for example by relocation to membranes. The C-termini of some PH domains have also been reported to bind the beta/lambda subunits of heterotrimeric G proteins.(www.mshri.on.ca/pawson)
C14078	RHO_Effector_Domain	Protein_Binding_Domain	RHO Effector Domain|HR1 Domain|Hr1 Repeat|REM Repeat	The REM repeat, which is also called rho effector or HR1 domain, was first described as a three times repeated homology region of the N-terminal non-catalytic part of protein kinase PRK1(PKN). The first two of these repeats were later shown to bind the small G protein rho known to activate PKN in its GTP-bound form. Similar rho-binding domains also occur in a number of other protein kinases and in the rho-binding proteins rhophilin and rhotekin. Recently, the structure of the N-terminal REM repeat complexed with RhoA has been determined by X-ray crystallography. It forms an antiparallel coiled-coil fold termed an ACC finger. (pfam.wustl.edu/cgi-bin/getdesc?name=HR1)
C14079	Transcriptional_Activation_Domain	Protein_Domain	Transcriptional Activation Domain	A DNA-binding domain binds to a specific DNA sequence and a transcriptional activation domain interacts with the basal transcriptional machinery. An association of a transcriptional activation domain with a DNA-binding domain promotes the assembly of RNA polymerase II complexes at the TATA box and increase transcription. (NCI)
C14080	DAG_PE-Binding_Domain	Ligand_Binding_Domain	DAG/PE-Binding Domain|C1 Domain|DAG Binding Domain|Diacylglycerol Binding Domain|Phorbol Ester Binding Domain|Protein Kinase C Conserved Region 1 Domain	The cysteine-rich N-terminal DAG/PE (Diacylglycerol/Phorbol Ester)-Binding (C1) Domain of PKC isoforms interacts with phorbol ester or with the phospholipid-derived second messenger diacylglycerol. C1 contains one or two copies of a Cys-rich domain about 50 amino-acid residues long; the domain binds two zinc ions, probably involving the conserved cysteines and histidines. Bound to DAG, C1 domains are involved in recruitment of proteins to the membrane via basic residues that interact with lipid head groups. Part of the domain contains two beta sheets that form a cavity and a short C-terminal alpha helix; another contains two zinc-binding sites that maintain the domain fold. Binding of diacylglycerol, or phorbol ester, to the domain results in modification of protein function. (NCI)
C14081	Estrogen_Binding_Domain	Ligand_Binding_Domain	Estrogen Binding Domain	The Estrogen Binding Domain is an all-helical ligand-binding domain within its nuclear hormone receptor. Steroid hormones, such as estrogen, and their receptors regulate eukaryotic gene expression, affecting target cell proliferation and differentiation. Hormone-receptor complexes recognize discrete DNA sequences upstream of transcription start sites. (NCI)
C14082	GTP_Binding_Domain	Ligand_Binding_Domain	GTP Binding Domain	Associated with binding and hydrolysis of GTP, the highly conserved GTP-Binding Domain is typically found in signaling RAS-related proteins of the small GTPase superfamily. (NCI)
C14083	Basolateral_Sorting_Signal	Protein_Sequence	Basolateral Sorting Signal|BASS	The polymeric immunoglobulin receptor is a model system to study protein traffic in epithelial cells. This receptor travels first to the basolateral surface where it can bind polymeric IgA or IgM. The receptor is then endocytosed and delivered to endosomes. The receptor is sorted into transcytotic vesicles which are exocytosed at the apical surface. The 103 amino acid cytoplasmic domain of the receptor contains several sorting signals. The 17 residues closest to the membrane are an autonomous signal for basolateral sorting. For endocytosis there are two signals, both of which contain tyrosines. Finally, transcytosis is signaled by serine phosphorylation. (From PubMed PMID1813030 and NCI)
C14084	KDEL_Motif	Protein_Sequence	KDEL Motif
C14085	DIX_Domain	Protein_Sequence	DIX Domain
C14086	Mitochondrial_Import_Sequence	Protein_Sequence	Mitochondrial Import Sequence
C14087	Membrane_Localization_Motif	Protein_Sequence	Membrane Localization Motif
C14088	Monobasic_Proteolytic_Cleavage_Site	Protein_Sequence	Monobasic Proteolytic Cleavage Site
C14089	Nuclear_Localization_Signal	Protein_Sequence	Nuclear Localization Signal
C14090	Signal_Peptide	Protein_Sequence	Signal Peptide|Leader Sequence|Signal Sequence	The N-terminal sequence of a secreted protein that interacts with a signal recognition particle and is required for transport through the cell membrane.
C14091	RNA_Binding_Domain	Retired_Concepts	RNA Binding Domain|RBD	RNA Binding Domains, such as the RRM, RGG box, and KH domain, mediate the interaction of RNAs with RNA-binding proteins. RRMs of about 90 amino acids consist of a four-stranded beta sheet adjacent to two alpha helixes. Within RRMs, conserved RNP-1 and RNP-2 motifs on the central beta sheets lie side by side; their side chains contact RNA. Found in hnRNP proteins, the RGG box is an RNA-binding motif containing five Arg-Gly-Gly repeats with intervening aromatic residues. The KH domain is found in several RNA-binding proteins in multiple repeats interspersed with RGG boxes. (NCI)
C14092	KH_Domain	RNA_Recognition_Motif	KH Domain|K Homology Domain	First identified in human hnRNPK protein, the conserved KH Domain of around 45-70 amino acids is present in a variety of nucleic acid-binding proteins. The domain may bind RNA in vivo. KH motifs are found in one or multiple copies, interspersed with RGG repeats, that may function cooperatively or, in single motif proteins, independently. KH domains can be separated into two groups: type-1 (beta-alpha-alpha-beta-beta-alpha) and type-2 (alpha-beta-beta-alpha-alpha-beta). The VIGXXGXXI sequence is preserved in the RNA binding motif between helix 1 and 2 (type-1) and helix 2 and 3 (type-2). The beta sheets are supported by alpha helixes. (NCI)
C14093	SET_Domain	Protein_Domain	SET Domain	SET domains appear to be protein-protein interaction domains. SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). The SET domain genes are widely represented in the eukaryotic genomes. Proteins bearing the widely distributed SET domain (ca. 130 amino acid) contribute to epigenetic mechanisms of gene regulation by methylation of lysine residues in histones and other proteins. The SET domain appears generally as one part of a larger multidomain protein. It appears that the varied domains that occur together with the SET domain are involved in recognizing protein substrates and ''reading'' histone tails in order to dictate which (if any) of their multiple lysine residues should get methylated. (From Pfam PF00856)
C14094	ARID_Domain	DNA_Binding_Domain	ARID Domain|AT-Rich Interaction Domain|AT-Rich Interactive Domain|BRIGHT Domain	The approximately 100-amino acid ARID (AT-Rich Interaction Domain) DNA-binding domain occurs in some transcriptional regulators (and perhaps modifiers of chromatin structure) involved in embryonic development, cell lineage, and cell cycle control. The domain shows more diversity in structure and function than the highly conserved sequence suggests: at least six alpha helices separated by beta-strands, loops, or turns. Although Bright, dead ringer, and MRF-2 preferentially bind to AT-rich sites, DNA binding of ARID-proteins is not necessarily sequence specific; ARID protein p270 of the SWI-SNF complex exhibits non-specific DNA binding activity. ARID family proteins may be involved in a wide range of DNA interactions. Inappropriate expression of ARID proteins is increasingly implicated in tumorigenesis. (NCI)
C14095	BTB_POZ_Domain	Protein_Binding_Domain	BTB/POZ Domain|BTB Domain|POZ Domain	The BTB/POZ domain is an approximately 120 amino acid long, hydrophobic region found in two distinct classes of transcriptional regulators that contain either a C-terminal basic leucine zipper motif (POK proteins) or a Zn-finger region (Bach proteins).  This domain has been shown to form homo-dimers in a number of BTB/POZ domain containing proteins. (NCI)
C14096	Zinc_Finger_Domain	Zinc-Binding_DNA-Binding_Motif	Zinc Finger Domain|Zinc Finger	The Zinc Finger Domain is found in many proteins that bind nucleic acids, typically DNA binding transcription factors. There are several classes of Zn finger proteins. Some bind Zn with only Cys residues (e.g., nuclear receptor superfamily) while others coordinate Zn with Cys and His residues. In the 25-amino acid C2H2 type motif, Zn2+ is held between a pair of anti-parallel beta strands and a single alpha helix by a pair of invariant Cys and His residues. The Cys/His type proteins generally contain repeated units and bind DNA as a monomer, while Cys/Cys proteins contain two units that bind inverted DNA repeats as homo- or heterodimers. In some Cys/Cys types the Zn ion folds the involved region into a globular structure that binds DNA.
C14097	C3H1_Zinc_Finger	Zinc_Finger_Domain	C3H1 Zinc Finger|Zinc Finger C-X8-C-X5-C-X3-H Type	Zinc finger domains are thought to be involved in DNA-binding. Different types exist depending on the cysteine residue positions. C-X8-C-X5-C-X3-H type zinc finger proteins often function in cell cycle or growth regulation, e.g. human TIS11B (butyrate response factor 1) and mouse TTP nuclear protein. The splicing factor U2AF 35-kD subunit, which mediates protein-protein and protein-RNA interactions required for 3-prime splice site selection, also contains this domain. Different CCCH zinc finger proteins interact with the 3-prime UTR of various mRNA. This type of zinc finger is often present in two copies. (NCI)
C14098	PHD_Finger	Metal_Binding_Site	PHD Finger|C4HC3 Zinc Finger|PHD Finger Motif|PHD-Finger|Plant Homeodomain (PHD) Type Zinc Finger	A C4HC3 zinc-finger-like motif, the PHD finger is found in nuclear proteins thought involved in chromatin-mediated transcriptional regulation. Single or multiple fingers are found. A specific function is not yet known, but it could be involved in protein-protein interactions important for assembly/activity of multi-component transcriptional regulatory complexes. In CBP it is an integral part of the acetyltransferase enzymatic core domain and contributes to CBP transcriptional activity. PHD fingers fold into an interleaved Zn-finger chelating two Zn ions in an atypical cross-braced conformation also shared by the FYVE and RING fingers; the zinc sites are located at opposite ends of a beta-sheet. Surrounding loops vary significantly in length and sequence between these three domains. (NCI)
C14099	HLH_Motif	Retired_Concepts	HLH Motif	In transcription regulators of cell cycle control, cell determination, and cell differentiation, the conserved HLH (Helix-Loop-Helix) Domain of 40-50 amino acids forms amphipathic helixes between a variable loop. HLHs typically mediate homo- or heterodimerization through interactions with self or other motifs to activate or inactivate trans-activating function. The N-helix often contains DNA-interacting basic residues; the C-helix typically contains characteristically spaced hydrophobic residues. An adjacent basic region of 15 amino acids in most HLH proteins binds to DNA. Basic (b)HLH proteins bind variants of the 'CANNTG' E-box. Proteins lacking the basic domain act as inhibitors, failing to bind DNA. bHLH proteins exhibit specific dimerization partner combinations. In calcium-binding proteins, certain invariant hydrophilic loop residues in the HLH motif bind calcium. (NCI)
C14100	Ankyrin_Repeat	Protein_Binding_Domain	Ankyrin Repeat|ANK Domain|ANK Repeat|Ankyrin Repeat Domain	Ankyrin Repeats are tandem modules of about 33 amino acids. The conserved domain structure has been described as side-by-side anti-parallel alpha helices connected by intervening beta hairpin motifs or as beta, alpha, alpha, beta secondary structures or as an L-shaped beta-hairpin and two alpha-helices. The repeats associate to form a higher order structure. Despite sequence variation, the domain core maintains a stable surface of contact residues to mediate protein-protein interactions. Target protein binding involves contacts by the beta hairpin tips and the helical bundle surface facing the Ankyrin groove. ANK repeats have been identified in over 1700 functionally diverse proteins, primarily from eukaryotes; no common theme among the protein targets has been identified. The Ankyrin cytoskeletal protein is composed almost entirely of these repeats. (NCI)
C14101	Armadillo_Repeat	Protein_Binding_Domain	Armadillo Repeat|ARM Domain|Armadillo/Beta-Catenin-Like Repeat|Beta-Catenin Binding Repeat|Beta-Catenin-Binding Domain|Beta-Catenin-Like Repeat	Identified in over 240 functionally diverse proteins from yeast to man, ARM Repeats are approximately 40-amino acids long and composed of two longer anti-parallel helices (H2 and H3) that follow a perpendicular short helix (H1). Tandem repeats form a right-handed superhelix (3 helixes per unit); tight repeat packing creates a cylindrical hydrophobic core throughout the structure. Lined by highly conserved residues, the positively charged groove of the superhelix appears to mediate interaction with acidic surfaces of target proteins. Despite amino acid variability, ARM repeat structures are highly conserved. Though involved in protein-protein interactions, no common features among target proteins have been identified. ARM repeats have a common phylogenetic origin with the HEAT repeat; both contain seven highly conserved hydrophobic residues. (NCI)
C14102	Beta-Catenin-Binding_Domain	Retired_Concepts	Beta-Catenin-Binding Domain
C14103	F_Box_Domain	Protein_Binding_Domain	F Box Domain|F Box	The F-box consists of three helices. The H1 helix packs orthogonally with the H2-H3 antiparallel pair. The F-box domain is a 42-48 amino acid conserved domain found at the N-terminus of F-box proteins. F-box proteins act as adaptor components of the modular E3 ubiquitin ligase SCF complex that functions in phosphorylation mediated ubiquitination. The F-box domain mediates interaction with Skp1, which links F-box proteins to a core ubiquitin-ligase complex composed of Rbx1, cdc53/Cul1 and the E2 conjugating enzyme cdc34. The C-terminal region of F-box proteins are also composed of various modular domain that interact with target substrates, often in a phosphorylation dependant manner.(www.mshri.on.ca/pawson)
C14104	GSK-Binding_Domain	Protein_Binding_Domain	GSK-Binding Domain	The GSK-Binding Domain of AXIN2 mediates interaction with GSK3-Beta. Involved in regulation of the WNT signaling pathway, AXIN2 organizes an APC/Beta-Catenin/GSK3-Beta/ AXIN2 complex that leads to Beta-Catenin degradation. (NCI)
C14105	PKC_Binding_Site	Protein_Binding_Domain	PKC Binding Site
C14106	Proline-Rich_Domain	Protein_Binding_Domain	Proline-Rich Domain|Proline-Rich Region	Proline-Rich Domains may be involved in heterotypic protein-protein interactions in signal transduction or other pathways. Found in signaling and structural proteins, WW domains are composed of approximately 40 amino acids folded as a stable, triple stranded beta-sheet that recognize proline-rich sequences. Some WW domains show a remarkable similarity to SH3 domains, which also appear to recognize some proline-rich sequences. Ena/VASP (Drosophila Enabled/Vasodilator-Stimulated Phosphoprotein) Family members regulate actin filament assembly, often through association with binding partners that display a proline-rich FPPPP motif. Ena/VASP proteins interact with these partners via the highly conserved Ena/VASP homology 1 (EVH1) domain. (NCI)
C14107	RGS_Domain	Protein_Binding_Domain	RGS Domain|RGS-Signaling Domain|Regulators of G Protein Signaling Domain	Typically 120 amino acids long, the RGS (Regulator of G protein Signaling) Domain is found in over 20 human proteins, bind activated G-alpha subunits, and are responsible for GAP function. Through other domains (e.g., DEP, PDZ, or PH) RGS proteins link to other signaling molecules. RGS domains contain conserved contiguous, or dispersed, GH subdomains (GH1, 2, and 3). All RGS domains share a tertiary structure of nine alpha helixes that form a right-handed anti-parallel bundle of helixes 4-7 and a terminal bundle of helixes 1-3 and 8-9. The 3-4, 5-6, and 7-8 helix loops form an interaction surface between RGS4 and Ga(i). RGS domains allosterically stabilize the G-alpha GTP binding pocket, accelerating GTPase activity. Thus, RGS Family members rapidly inactivate G protein signal transmission from seven transmembrane receptors in GPCR signaling pathways. (NCI)
C14108	SH2-Binding_Motif	Protein_Binding_Domain	SH2-Binding Motif	Typically found in signaling proteins, the SH2-Binding Motif mediates regulated high-affinity physical interaction (binding) with the target SH2 (SRC Homology 2) domain. SH2 domains of ~100 amino acids bind to specific phosphotyrosine (pY)-containing motifs with dissociation constants of ~50-500 nM. A conserved pocket of SH2 domains recognizes the pY, and a more variable pocket binds residues C-terminal to pY that confer specificity. SH2 domains balance high affinity for pY and recognition of adjacent residues to allow specific discrimination. The SH2 domain, an anti-parallel b-sheet between a-helices, provides a positively charged b-sheet pocket for binding of pY moieties, and an extended b-sheet surface for binding residues C-terminal to pY. B-sheet surface differences have significant effects on ligand-specificity. (NCI)
C14109	SH3-Binding_Motif	Protein_Binding_Domain	SH3-Binding Motif	Typically found in proteins involved in signaling pathways, the SH3-Binding Motif is a peptide sequence that mediates regulated high-affinity physical interaction (binding) with the SH3 (SRC Homology 3) domain in target protein partners. The SH3-binding motif often share proline-rich stretches containing a common PXXP motif. (NCI)
C14110	PXXP_Motif	SH3-Binding_Motif	PXXP Motif	The SH3 domain, often seen in signaling pathway proteins, frequently binds to a conserved PXXP Motif usually found in proline-rich regions of target proteins. The SH3 domain contains a site located between the RT and n-SRC loops that binds the PXXP motif, which then adopts a poly-proline type II (PPII) conformation. PXXP motifs are often clustered and have residues that contribute to binding specificity. Class I motifs have an amino to carboxy terminal binding orientation and include sites specific for the SRC oncoprotein. More promiscuous in their binding, Class II motifs have a carboxy to amino terminal binding orientation, PXXP can be in either of two positions, and they have basic residues at the C-terminus. (NCI)
C14111	WD_Repeat	Protein_Binding_Domain	WD Repeat|G-Beta Repeat|Trp-Asp Repeat|Tryptophan-Aspartate Repeat|WD Domain|WD40 Domain	WD40 Repeats are found in signal transduction, mRNA processing, cytoskeletal assembly, and cell cycle proteins; none are catalytic. G-beta is the prototypic WD40 protein. WD-40 proteins contain 5-8 repeats of about 40 residues, with a central Trp-Asp (WD) motif. The repeats may span the entire protein or make up either terminal or the central section. WD40 domains serve as a platform to which proteins stably or reversibly bind; some may recognize phosphoSer and -Thr peptides. The repeat forms a closed ring propeller with seven blades each composed of a four-stranded anti-parallel b-sheet. Each repeat forms the first three strands of one blade and the last strand in the next blade. The last C-terminal repeat completes the blade of the first repeat. Residues on the propeller top surface likely coordinate interactions with other proteins or ligands.
C14112	_9q32-q34	Chromosome_Band	9q32-q34	A chromosome band present on 9q
C14113	_14q24-q31	Chromosome_Band	14q24-q31	A chromosome band present on 14q
C14114	Calcium-Binding_Domain	Metal_Binding_Site	Calcium-Binding Domain	Many calcium-binding proteins belong to the same evolutionary family and share a type of calcium-binding domain known as the EF-hand. This type of domain consists of a twelve residue loop flanked on both side by a twelve residue alpha-helical domain. In an EF-hand loop the calcium ion is coordinated in a pentagonal bipyramidal configuration. The six residues involved in the binding are in positions 1, 3, 5, 7, 9 and 12; these residues are denoted by X, Y, Z, -Y, -X and -Z. The invariant Glu or Asp at position 12 provides two oxygens for liganding Ca (bidentate ligand). (From InterPro IPR002048)
C14115	_3q22_2	Chromosome_Band	3q22.2	A chromosome band present on 3q
C14116	_12p13_2	Chromosome_Band	12p13.2	A chromosome band present on 12p
C14117	EXO_I_Motif	Protein_Domain	EXO I Motif
C14118	EXO_II_Motif	Protein_Domain	EXO II Motif
C14119	EXO_III_Motif	Protein_Domain	EXO III Motif
C14120	_10q24_1	Chromosome_Band	10q24.1	A chromosome band present on 10q
C14121	_8p22-p21	Chromosome_Band	8p22-p21	A chromosome band present on 8p
C14122	_10p15-p14	Chromosome_Band	10p15-p14	A chromosome band present on 10p
C14123	_5q33_2-qter	Chromosome_Band	5q33.2-qter	A chromosome band present on 5q
C14124	_17q21-q23	Chromosome_Band	17q21-q23	A chromosome band present on 17q
C14125	_4q31_23	Chromosome_Band	4q31.23	A chromosome band present on 4q
C14126	_5q32	Chromosome_Band	5q32	A chromosome band present on 5q
C14127	_4q11-q13	Chromosome_Band	4q11-q13	A chromosome band present on 4q
C14128	Yolk_Sac	Extraembryonic_Structure	Yolk Sac
C14129	_5q23	Chromosome_Band	5q23	A chromosome band present on 5q
C14130	_3q13_12	Chromosome_Band	3q13.12	A chromosome band present on 3q
C14131	UBA_Domain	Protein_Domain	UBA Domain|Ubiquitin-Associated Domain	The UBA-domain is a sequence motif found in multiple enzyme classes having connections to ubiquitin and the ubiquitination pathway, including human ubiquitin isopeptidase T and several other ubiquitin C-terminal hydrolases catalyzing regulatory protein-deubiquitination. Mammalian proto-oncogene c-cbl is a protein interacting with multiple signal transduction factors. Cbl has recently been shown to undergo regulatory ubiquination upon macrophage stimulation. (From http://www.isrec.isb-sib.ch/domains/uba/index.html)
C14132	_6p22_3	Chromosome_Band	6p22.3	A chromosome band present on 6p
C14133	_11p15_4	Chromosome_Band	11p15.4	A chromosome band present on 11p
C14134	Macromolecular_Structure	Microanatomy	Macromolecular Structure|Molecular Structure	The location of the atoms, groups or ions relative to one another in a molecule, as well as the number and location of chemical bonds.
C14135	Cell_Structure	Cell_Part	Cell Structure	The components of the cell and how they are arranged.
C14136	Extracellular_Structure	Tissue_Part	Extracellular Structure	Any structures that are not enclosed intracellularly are considered extracellular structure, including structures on the cell surface. (NCI)
C14138	Aggressive	Disease_Clinical_Modifier	Aggressive|aggressive	A quickly growing cancer.
C14139	Immunocompromised	Patient_Characteristics_Modifier	Immunocompromised|immunocompromised|immunocompromised host|immunocompromised patient|immunosuppressed host|immunosuppressed patient	Having a weakened immune system caused by certain diseases or treatments.
C14140	Acute	Disease_Clinical_Modifier	Acute|acute	Having a severe and rapid onset of symptoms with short duration.
C14141	Chronic	Disease_Clinical_Modifier	Chronic|CHR|chronic	A disease or condition that persists or progresses over a long period of time.
C14142	Encapsulated	Disease_Gross_Finding_Modifier	Encapsulated|encapsulated	(en-KAP-soo-lay-ted) Confined to a specific, localized area and surrounded by a thin layer of tissue.
C14143	Malignant	Disease_Morphology_Modifier	Malignant|MAL|malignant	(ma-LIG-nant) Cancerous; a growth with a tendency to invade and destroy nearby tissue and spread to other parts of the body.
C14144	Anaplastic	Disease_Morphology_Modifier	Anaplastic|anaplastic|undifferentiated	(an-ah-PLAS-tik) A term used to describe cancer cells that divide rapidly and have little or no resemblance to normal cells.
C14145	Indolent	Disease_Clinical_Modifier	Indolent|indolent	(IN-doe-lint) A type of cancer that grows slowly.
C14146	Localized	Disease_Clinical_Modifier	Localized|Localised|localized	Restricted to the site of origin, without evidence of spread.
C14147	Nonmelanomatous	Disease_Morphology_Modifier	Nonmelanomatous|nonmelanomatous	Having to do with skin cancer that develops in basal cells or squamous cells but not in melanocytes (pigment-producing cells of the skin).
C14148	Nonmetastatic	Disease_Gross_Finding_Modifier	Nonmetastatic|nonmetastatic	Cancer that has not spread from the primary (original) site to other sites in the body.
C14149	Osteolytic	Disease_Morphology_Modifier	Osteolytic|osteolytic	Causing the breakdown of bone.
C14150	Tumor-Derived	Disease_Laboratory_Finding_Modifier	Tumor-Derived|tumor-derived	Taken from an individual's own tumor tissue; may be used in the development of a vaccine that enhances the body's ability to build an immune response to the tumor.
C14151	Unresectable	Disease_Treatment_Modifier	Unresectable|unresectable	Unable to be removed with surgery.
C14152	Hematogenous	Disease_Clinical_Modifier	Hematogenous|hematogenous	Originating in the blood or spread through the bloodstream.
C14154	Child	Retired_Concepts	Pediatric|Childhood
C14155	Alveolar	Anatomy_Modifier	Alveolar	Of or relating to the alveoli.
C14156	Apoptotic	General_Modifier	Apoptotic	Pertaining to apoptosis.
C14157	Borderline	Disease_Morphology_Modifier	Borderline	straddling the dividing line between two categories.
C14158	High_Grade	Disease_Grade_Modifier	High Grade	denoting fast growth.
C14159	Invasive	Disease_Morphology_Modifier	Invasive|INV	Marked by a tendency to spread, especially into healthy surrounding tissue.
C14160	In_Situ	Disease_Morphology_Modifier	In Situ	in the natural or normal place, confined to the site of origin without invasion of neighboring tissues. (On-line Medical Dictionary)
C14161	Low_Grade	Disease_Grade_Modifier	Low Grade	denoting slow growth; indolent.
C14162	Moderately_Differentiated	Disease_Grade_Modifier	Moderately Differentiated|Moderately Well Differentiated
C14163	Mucinous	Disease_Morphology_Modifier	Mucinous|mucinous	(MYOO-sin-us) Containing or resembling mucin, the main compound in mucus.
C14164	Myoepithelial	General_Modifier	Myoepithelial
C14165	Normal	General_Modifier	Normal|NL	Being approximately average or within certain limits; conforming with or constituting a norm or standard or level or type or social norm.
C14166	Papillary	Disease_Morphology_Modifier	Papillary|PAPIL	of or relating to or resembling papilla.
C14167	Poorly_Differentiated	Disease_Grade_Modifier	Poorly Differentiated
C14168	Serous	Disease_Morphology_Modifier	Serous|serous	(SEER-us) Having to do with serum, the clear liquid part of blood.
C14169	Tubular	Disease_Morphology_Modifier	Tubular	shaped like a tube; of or pertaining to a tubule. (On-line Medical Dictionary)
C14170	Villous	Disease_Morphology_Modifier	Villous	abounding in, or covered with, fine hairs.
C14171	Well_Differentiated	Disease_Grade_Modifier	Well Differentiated
C14172	Benign	Disease_Morphology_Modifier	Benign|benign	(beh-NINE) A noncancerous growth that does not invade nearby tissue or spread to other parts of the body.
C14173	Recurrent	Disease_Clinical_Modifier	Recurrent|RECUR	occurring again.
C14174	Metastatic	Disease_Gross_Finding_Modifier	Metastatic|METC|metastatic	(MET-uh-STAT-ik) Having to do with metastasis, which is the spread of cancer from one part of the body to another.
C14175	Diffuse	Disease_Morphology_Modifier	Diffuse|diffuse	Widely spread; not localized or confined.
C14176	Undifferentiated	Disease_Grade_Modifier	Undifferentiated|undifferentiated	A term used to describe cells or tissues that do not have specialized ("mature") structures or functions. Undifferentiated cancer cells often grow and spread quickly.
C14179	Adenovirus	Double_Stranded_DNA_Virus	Adenovirus|adenovirus	A group of DNA containing viruses which cause respiratory disease, including one form of the common cold.
C14180	Amphibian	Vertebrate	Amphibian|Amphibians	cold blooded chordates; larva are usually aquatic, breathing by gills; adults are terrestrial or aquatic, breathing by lungs and through moist glandular skin.
C14181	Animal_Virus	Other_Virus_Grouping	Animal Virus|Viruses, Animal	An animal pathogen that is a virus.
C14182	Animal	Organisms	Animal|Animals	A living, sentient organism that has membranous cell walls, requires oxygen and organic foods, and is capable of voluntary movement, as distinguished from a plant or mineral.
C14183	Laboratory_Animal	Animal|Laboratory_Organism	Laboratory Animal
C14184	Transgenic_Animal	Laboratory_Animal	Transgenic Animal|Animals, Transgenic|Transgenic|Transgenics	Experimental organism whose genome has been altered by the transfer of a gene or genes from another species or breed.
C14185	Armadillo	Mammal	Armadillo|Mammals, Armadillos	Any of several small, burrowing, chiefly nocturnal mammals with body covered with strong horny plates.
C14186	Alpharetrovirus	Retroviridae	Alpharetrovirus|Avian Retrovirus|Retroviruses, Type C, Avian|Type C Avian Retrovirus	An rna-type retrovirus with a c-type morphology. The viruses have a widespread distribution and include both exogenous (vertical and horizontal transmission) and endogenous viruses of chickens and some other birds. Avian Leukosis virus is the type species. Distantly related endogenous sequences are found in birds and mammals. Virus infections are associated with malignancies and some other diseases such as wasting, and osteopetrosis. Many oncogene-containing members of the genus have been isolated. (from http://www.virustaxonomyonline.com/)
C14187	Bacteria	Prokaryote	Bacteria|Bacterium|bacteria	A large group of single-cell microorganisms.  Some cause infections and disease in animals and humans.  The singular of bacteria is bacterium.
C14188	Bacteriophage	Virus	Bacteriophage|Viruses, Bacterial	A virus that infects and lyses certain bacteria.
C14189	Bird	Vertebrate	Bird|Avian|Birds	warmblooded oviparous tetrapods with feathers, one occipital condyle, forelimb modified into wings, heart with 2 ventricles.
C14190	Bovine_Papillomavirus	Papillomavirus	Bovine Papillomavirus|BPV	causes papillomas on the head and neck and in the mouth and esophagus; injection into hamsters and mice produces fibrosarcomas.
C14191	Cat	Felidae	Cat|Feline Species|Felis catus|Mammals, Cats	The domestic cat, Felis catus.
C14192	Cow	Bovidae	Cow|Bos bovis|Bos primigenius taurus|Bos taurus|Bovine|Bovine Species|Cattle	Domesticated ungulates that are raised for beef, dairy products, and leather, and used for labor.
C14193	Chicken	Bird	Chicken|Gallus gallus	The common domestic fowl, Gallus gallus.
C14194	Chimera	Other_Organism_Groupings	Chimera	An organism with tissues derived from two or more genotypes.  A chimera may develop naturally by somatic cell mutation or be created artificially.
C14195	Cryptococcus_neoformans	Fungi	Cryptococcus neoformans|Crypto	A species of the fungus cryptococcus, the causative agent of cryptococcosis.
C14196	Cytomegalovirus	Herpesvirus	Cytomegalovirus|CMV|HHV-5|HHV5|Human Herpesvirus 5|cytomegalovirus	A virus that may be carried in an inactive state for life by healthy individuals.  It is a cause of severe pneumonia in people with a suppressed immune system, such as those undergoing bone marrow transplantation or those with leukemia or lymphoma.
C14197	Flies	Insect	Flies	A two-winged insect in the order Diptera. Typical used to refer to Drosophila melanogaster, the fruit fly; the subject of classical genetic studies, because of its rapid generation time and easily observed characteristics.
C14198	Disease_Vector	Infectious_Agent|Invertebrate	Disease Vector|Disease Vectors|Vector (Infectious Agent)	An invertebrate animal (e.g., tick, mite, mosquito, bloodsucking fly) capable of transmitting an infectious agent among vertebrates.
C14199	DNA_Tumor_Virus	Tumor_Virus	DNA Tumor Virus	A virus which uses DNA to code its genome and causes tumors in animals.
C14200	DNA_Virus	Virus	DNA Virus|Virus, DNA|Virus-DNA|Viruses, DNA	A DNA virus is a virus that has DNA as its genetic material and does not use an RNA intermediate during replication.
C14201	Dog	Canidae	Dog|Canine Species|Canis familiaris|Mammals, Dogs	The domestic dog Canis familiaris.
C14202	Drosophila	Flies	Drosophila	A genus of small, American flies, Diptera. The best known species is D. Melanogaster, often called the fruit fly, but more correctly termed the vinegar fly. First investigated by T.H.Morgan and his group, it has been extensively used in genetic studies. More recently it has been used for studies of embryonic development. (On-line Medical Dictionary)
C14203	Enterovirus	Picornavirus	Enterovirus	A (+) strand single strand RNA virus of the picornavirus family.  Poliovirus is an enterovirus.
C14204	Epstein-Barr_Virus	Herpesvirus	Epstein-Barr Virus|EBV|Epstein Barr Virus|Epstein-Barr virus|Virus-Epstein-Barr	A common virus that remains dormant in most people. It has been associated with certain cancers, including Burkitt's lymphoma, immunoblastic lymphoma, and nasopharyngeal carcinoma.
C14205	Equine_Infectious_Anemia_Virus	Lentivirus	Equine Infectious Anemia Virus|EIAV	Equine Infectious Anemia Virus, a lentivirus related to HIV (DCB-BC)
C14206	Escherichia_coli	Bacteria	Escherichia coli|E. coli
C14207	Fish	Vertebrate	Fish|Fish (NOS)	A vertebrate animal usually having fins and a covering of scales or plates. It breathes by means of gills, and lives almost entirely in the water. (from Webster, 1913)
C14208	Flavivirus	ssRNA_Virus_plus_Strand	Flavivirus	A family of enveloped viruses with a genome consisting of a single molecule of linear positive-sense single-stranded RNA. They infect molluscs, mammals, and birds and are transmitted by arthropod vectors.  The family includes the hepatitis C and hepatitis G viruses.
C14209	Fungi	Organisms	Fungi|Fungus|fungus	A kingdom of eukaryotic, heterotrophic organisms that live as saprobes or parasites, including mushrooms, yeasts, smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi refer to those that grow as multicellular colonies (mushrooms and molds).
C14210	Goat	Bovidae	Goat|Capra hircus|Caprine Species|Mammals, Goats	Any of various hollow-horned, bearded ruminant mammals of the genus Capra, originally of mountainous areas of the Old World, especially any of the domesticated forms of C. hircus, raised for wool, milk, and meat. (from American Heritage Dictionary on line)
C14211	Guinea_Pig	Rodent	Guinea Pig|Cavia porcellus|Mammals, Guinea Pigs	The domesticated guinea pig, Cavia porcellus, used for pets and biomedical research.
C14212	Hamster	Muridae	Hamster|Mammals, Hamsters	Any member of four genera of the rodent family Muridae; short-tailed Old World burrowing rodents with large cheek pouches.
C14213	Hantavirus	ssRNA_Virus_Strand	Hantavirus
C14214	Hepadnavirus	Double_Stranded_DNA_Virus	Hepadnavirus	The Hepadnavirus Family derives its name from its hepatotropic nature and double-stranded DNA genome. The hepadnaviral genome is unique in that the plus strand is incomplete, leaving 15-50% of the molecule single-stranded and the minus strand while being complete, possesses a discontinuity at a unique site. The hepatitis B virus (HBV) is the only causative agent for a human disease within the family. (http://www.stanford.edu/group/virus/hepadna/2000/hepadnavirus.html)
C14215	Hepatitis_B_Virus	Hepadnavirus|Hepatitis_Virus	Hepatitis B Virus|HBV|Virus-Hepatitis B|hepatitis B virus	A virus that causes hepatitis (inflammation of the liver). It is carried and passed to others through blood or sexual contact. Also, infants born to infected mothers may become infected with the virus.
C14216	Hepatitis_Virus	Other_Virus_Grouping	Hepatitis Virus
C14217	Herpesvirus	Double_Stranded_DNA_Virus	Herpesvirus|Herpes Virus|Virus-Herpes|herpes virus	(HER-peez VYE-rus) A member of the herpes family of viruses.
C14218	Human_Herpesvirus_6	Herpesvirus	Human Herpesvirus 6|HHV-6|HHV6|Virus-HHV6	A human herpesvirus that has been found in certain lymphoproliferative disorders, replicates in a number of different types of leukocytes, and is associated with the childhood disease roseola (exanthema subitum). (On-line Medical Dictionary)
C14219	Human_Immunodeficiency_Virus	Lentivirus	Human Immunodeficiency Virus|HIV|Virus-HIV|human immunodeficiency virus	The cause of acquired immunodeficiency syndrome (AIDS).
C14220	Human_Immunodeficiency_Virus_1	Human_Immunodeficiency_Virus	Human Immunodeficiency Virus 1|HIV-1|Human Immunodeficiency Virus, Type 1
C14221	Human_Immunodeficiency_Virus_2	Human_Immunodeficiency_Virus	Human Immunodeficiency Virus 2|HIV-2|Human Immunodeficiency Virus, Type 2	An HIV species related to HIV-1 but carrying different antigenic components and with differing nucleic acid composition. It shares serologic reactivity and sequence homology with the simian Lentivirus SIV and infects only T4-lymphocytes expressing the CD4 phenotypic marker.
C14222	Horse	Equidae	Horse|Equine|Equine Species|Equus caballus	The domestic horse, Equus caballus.
C14223	HTLV-1	Deltaretrovirus	HTLV-1|HTLV-I|Human T-Lymphotropic Virus 1|Human T-Lymphotropic Virus, Type I|Virus-HTLV-I|human T-cell leukemia virus type 1	A human immunodeficiency virus; a species of lentivirus causing leukemia and sometimes a mild immunodeficiency.
C14224	HTLV-2	Deltaretrovirus	HTLV-2|HTLV-II|Human T-Lymphotropic Virus 2|Human T-Lymphotropic Virus, Type II|Virus-HTLV-II	A human retrovirus associated with T-cell hairy cell leukemia.
C14225	Human	Primate	Human|Homo sapiens|Human, General	Belonging to man or mankind; pertaining to man or to the race of man; use of man as experimental subject or unit of analysis in research
C14226	Human_Papillomavirus	Papillomavirus	Human Papillomavirus|HPV|Human Papilloma Virus|Human Papillomaviruses|human papillomavirus	(pap-ih-LO-ma-VYE-rus) A virus that causes abnormal tissue growth (warts) and is often associated with some types of cancer.
C14227	Insect	Invertebrate	Insect|Invertebrates, Insects	have 3 pairs of legs, 3 body regions, 1 pair of antennae, and often 1-2 pairs of wings; 26 Orders, 703,500 known species.
C14228	Invertebrate	Animal	Invertebrate|Invertebrata|Invertebrates|Invertebrates, General
C14229	JC_Virus	Polyomavirus	JC Virus	One of two polyomaviruses found in humans. JC virus can infect the respiratory system, kidneys, or brain, sometimes causing the fatal progressive multifocal leukoencephalopathy in the latter case. It is very widespread with approximately 80 percent of the adult population in the United States having antibodies to and JC. (from WordIQ.com)
C14230	Lymphocytic_Choriomeningitis_Virus	Arenavirus	Lymphocytic Choriomeningitis Virus|LCMV	etiologic agent of lymphocytic choriomeningitis; occurs naturally in mice, dogs and monkeys.
C14231	Macaque	Monkey	Macaque|Macaca|Macacus|Macaques	Any of several species of short-tailed monkeys of the genus Macacus.
C14232	Cynomolgus_Monkey	Macaque	Cynomolgus Monkey|Crab Eating Macaque|Macaca cynomolgus|Macaca fascicularis	A macaque, Macaca fascicularis (M. cynomolgus), found mostly in southeastern Asia, Borneo, and the Philippines.
C14233	Rhesus_Monkey	Macaque	Rhesus Monkey|Macaca mulatta|Rhesus|Rhesus Macaque	A pale brown Asian macaque (Macaca mulatta) often used in medical research.
C14234	Mammal	Vertebrate	Mammal|Mammals, General	Any warm-blooded vertebrate having the skin more or less covered with hair; young are born alive except for the small subclass of monotremes and nourished with milk.
C14235	Mouse_Mammary_Tumor_Virus	Betaretrovirus	Mouse Mammary Tumor Virus|MMTV	Type B retrovirus.  Etiologic agent of mouse mammary tumors.  Transmitted horizontally through the lactating mammary gland and vertically through the germline.  Mechanism of tumorigenesis involves the activation of cellular int genes by promoter/enhancer insertion.
C14236	Mason-Pfizer_Monkey_Virus	Betaretrovirus	Mason-Pfizer Monkey Virus|MPMV	Mason-Pfizer Monkey Virus; causes AIDS-like disease (NCI)
C14237	Measles_Virus	Morbillivirus	Measles Virus	A morbillivirus that causes the childhood disease measles and is responsible for subacute sclerosing panencephalitis.
C14238	Mouse	Muridae	Mouse|Mammals, Mice|Mice|Murine|Mus	Any of numerous species of small rodents belonging to the genus Mus and various related genera of the family Muridae.
C14239	Nude_Mouse	Immunodeficient_Mouse	Nude Mouse|Athymic Mouse|Athymic Nude Mouse|Nude|athymic, nude mouse	A hairless mutant mouse with thymic hypoplasia, lacking T-cells.  They are unable to reject transplants.
C14240	Transgenic_Mouse	Transgenic_Animal	Transgenic Mouse|Transgenic Mice	A mouse whose genome has been altered by the inclusion of foreign genetic material. The technique involves microinjection of foreign DNA fragments into the nucleus of an fertilized egg. The inserted gene becomes integrated into every cell and tissue of the mouse.
C14241	Moloney_Leukemia_Virus	Mouse_Leukemia_Virus	Moloney Leukemia Virus|M-MuLV|MLV|MoMuLV|Moloney Murine Leukemia Virus|Moloney Virus
C14242	Moloney_Sarcoma_Virus	Mouse_Leukemia_Virus	Moloney Sarcoma Virus|MMSV|MoMSV|MoMuSV|Moloney Murine Sarcoma Virus
C14243	Monkey	Primate	Monkey|Monkeys	Any haplorhine primate not belonging to the family Tarsiidae, Hylobatidae, Pongidae, or Hominidae; this does not correspond to any taxon. This group is divided into Old World monkeys (Cercopithecidae) and New World monkeys (Callitrichidae and Cebidae).  Many types are used as an experimental model for human disease and drug testing.
C14244	Mouse_Leukemia_Virus	Gammaretrovirus	Mouse Leukemia Virus|MuLV|Murine Leukemia Virus	Type C retroviruses that cause leukemia in mice.  Includes the Abelson, AKR, Friend, Moloney, Gross, and other leukemia viruses.
C14245	Mumps_Virus	Rubulavirus	Mumps Virus	A type of paramyxovirus. It spreads from person to person through coughs, sneezes and saliva, as well as through contact with contaminated items and surfaces. Once the mumps virus enters the body, it passes into the bloodstream and can spread to many different glands and to the brain.
C14246	Muridae	Rodent	Muridae	Taxonomic family which includes mice and rats.
C14247	Avian_Myeloblastosis_Virus	Alpharetrovirus	Avian Myeloblastosis Virus
C14248	Nematodes	Invertebrate	Nematodes	Nematodes are soil-inhabiting roundworms of the Phylum Nematoda.
C14249	Tumor_Virus	Other_Virus_Grouping	Tumor Virus|Oncogenic Virus|Tumor Viruses	A virus capable of transforming a cell to a malignant phenotype. (BioTech Life Science Dictionary)
C14250	Organisms	root_node	Organism|Organisms|Taxon|organism	A living thing, such as an animal, a plant, a bacterium, or a fungus.
C14251	Papillomavirus	Papovavirus	Papillomavirus|Papilloma Virus|Virus-Papilloma	A genus of viruses (family Papovaviridae) containing DNA, having virions about 55 nm in diameter, and including the papilloma and warts viruses of man and other animals, some of which are associated with inductions of carcinoma.
C14252	Baboon	Monkey	Baboon|Baboons|Papio	Large terrestrial monkey found in Africa and Arabia; the largest non-Hominid member of the primate order. They have long dog-like muzzles, close-set eyes, heavy powerful jaws, thick fur except on their muzzle, short tail and often brightly coloured ischial callosities.
C14253	Papovavirus	Double_Stranded_DNA_Virus	Papovavirus|Virus-Papova	Any of a group of animal viruses associated with or causing papillomas or polyomas.
C14254	Human_Parainfluenza_Virus_1	Paramyxovirus	Human Parainfluenza Virus 1|HA2|Hemadsorption Type 2 Virus
C14255	Paramyxoviridae	ssRNA_Virus_Strand	Paramyxoviridae	A family of negative-strand single-strand RNA viruses which includes Mumps and Measles viruses.
C14256	Picornavirus	ssRNA_Virus_plus_Strand	Picornavirus	(+)-sense ssRNA viruses; have no envelope or core, nor any surface projections; replication is in the cytoplasm and is via two distinct partially double-stranded replicative intermediates; most of host range is species specific.
C14257	Plant_Virus	Other_Virus_Grouping	Plant Virus|Viruses, Plant	viruses that replicate in and may produce diseases of higher plants; see RTs for specific organisms.
C14258	Plant	Organisms	Plant|Plants|Plants, General	Any living organism that typically synthesizes its food from inorganic substances, possesses cellulose cell walls, responds slowly and often permanently to a stimulus, lacks specialized sense organs and nervous system, and has no powers of locomotion. (EPA Terminology Reference System)
C14259	Poliovirus	Enterovirus	Poliovirus|Polio Virus	A member of the enterovirus genus of RNA viruses
C14260	Polyomavirus	Papovavirus	Polyomavirus|Polyoma	normally present in hosts as latent infections, potentially oncogenic; host DNA may become enclosed in virus capsids creating a 'pseudovirus'; isolated from man, mouse, rabbit, hamster and several species of monkey.
C14261	Poxvirus	Double_Stranded_DNA_Virus	Poxvirus	Any virus of the family Poxviridae that can cause pox diseases in vertebrates.
C14262	Primate	Mammal	Primate|Mammals, Primates|Primates	The taxonomic order that includes man, monkeys, and lemurs.
C14263	Prokaryote	Organisms	Prokaryote|Prokaryotae|Prokaryotes|Prokaryotic Cells	Unicellular organisms lacking a nuclear membrane to compartmentalize the genetic material.
C14264	Rabbit	Leporidae	Rabbit|Mammals, Rabbits	Any of the smaller species of the genus Lepus, especially the common European species (Lepus cuniculus), and the common American rabbit (L. sylvalica). A common research animal. (from DCB-CI)
C14265	Frog	Amphibian	Frog|Frogs	An amphibian in the order Anura, which includes the toads. The commonest frog genera are Rana (grass frogs) and Hyla (tree frogs).
C14266	Rat	Muridae	Rat|Mammals, Rats|Rattus norvegicus	THe common rat, Rattus norvegicus, often used as an experimental organism.
C14267	Respiratory_Syncytial_Virus	Pneumovirinae	Respiratory Syncytial Virus|RSV|respiratory syncytial virus	A virus that causes respiratory infections with cold-like symptoms.
C14268	Retroviridae	Virus	Retroviridae|Retrovirus|Retroviruses|Virus-Retrovirus	This family of viruses resembles the orthomyxoviruses in size and shape, but arestructurally more complex; they possess RNA-dependent DNA polymerases (reverse transcriptases). Virions are about 100 nm in diameter, enveloped, and contain two identical molecules of positive sense, single-stranded RNA of high molecular weight.  This RNA serves as a template for the synthesis of a complementary DNA, which may be integrated into the host DNA.
C14269	RNA_Virus	Virus	RNA Virus|Virus-RNA|Viruses, RNA	A virus whose genome consists of RNA.
C14270	Rodent	Mammal	Rodent|Mammals, Rodents|Rodentia|Rodents	Taxonomic order that includes mice, rats, guinea pigs, squirrels, beavers, and many others.
C14271	Saccharomyces_cerevisiae	Yeast	Saccharomyces cerevisiae|S. cerevisiae	A species of unicellular fungus used as a research subject and in baking and beer brewing.
C14272	Serratia_marcescens	Bacteria	Serratia marcescens
C14273	Sheep	Bovidae	Sheep|Ovis aries	Any one of several species of ruminants of the genus Ovis, native of the higher mountains of both hemispheres, but most numerous in Asia; the domestic sheep, Ovis aries.
C14274	Simian_Immunodeficiency_Virus	Lentivirus	Simian Immunodeficiency Virus|SIV	An HIV-like virus that infects monkeys, chimpanzees, and other non-human primates. (AIDS Info HIV Glossary)
C14275	Specific_Pathogen_Free_Organism	Laboratory_Organism	Specific Pathogen Free Organism	Animals or humans raised in the absence of a particular disease-causing virus or other microorganism. Less frequently plants are cultivated pathogen-free.
C14276	Spleen_Focus-Forming_Virus	Mouse_Leukemia_Virus	Spleen Focus-Forming Virus|Friend Spleen Focus-Forming Virus	Defective virus found in certain strains of Friend virus, detected by its ability to form foci in spleens of mice and believed to be responsible in those strains for the production of a leukemia associated with polycythaemia rather than anemia. (DictionaryBarn.com)
C14277	Simian_T-Lymphotropic_Virus_Type_I	Deltaretrovirus	Simian T-Lymphotropic Virus Type I|STLV
C14278	Streptomyces	Bacteria	Streptomyces
C14279	SV40	Polyomavirus	SV40|Simian Vacuolating Virus 40|Simian Virus 40|Virus-SV40	A small (40 to 45 nm) DNA virus of the genus Polyomavirus, family Papovaviridae; the cause of seemingly inapparent infections in monkeys, especially rhesus, and a common contaminant of monkey cell cultures; the virus may cause inapparent infection in humans and may be excreted in stools of children for several weeks; it can produce fibrosarcoma in suckling hamsters, and transformation may occur in human diploid cells; it may also form "hybrid" virus in cells also infected with certain adenoviruses. (On-line Medical Dictionary)
C14280	Pig	Suidae	Pig|Mammals, Pigs|Porcine Species|Sus scrofa domestica	The domestic pig Sus scrofa domestica
C14281	Vaccinia_Virus	Poxvirus	Vaccinia Virus|Vaccinia	DNA viruses used in several biotechnology applications, including expression vector systems. (from On-line Medical Dictionary)
C14282	Vertebrate	Animal	Vertebrate|Vertebrate Animals|Vertebrates	Animals having a bony or cartilaginous skeleton with a segmented spinal column and a large brain enclosed in a skull or cranium.
C14283	Virus	Organisms	Virus|Viruses|Viruses, General|virus	(VYE-rus) A microorganism that can infect cells and cause disease.
C14284	Woman	Human	Woman|Human, Female	A woman is an adult, female human.
C14285	Xenopus	Frog	Xenopus	Any of various aquatic, tongueless, clawed frogs of the genus Xenopus, native to southern Africa, especially X. laevis, widely used in the study of vertebrate development. (Bartleby.com)
C14286	Yeast	Fungi	Yeast	Various single-celled members of the fungal families, ascomycetes, basidiomycetes and imperfect fungi that tend to be unicellular for the greater part of their life cycle. (from On-line Medical Dictionary)
C14287	Zebrafish	Fish	Zebrafish|Brachydanio rerio|Danio rerio|Zebra danio	Brachydanio rerio, species of small freshwater aquarium fish with a transparent embryo making it possible to follow progeny of single cells until quite late stages of development. This, together with the availability of mutant lines make it an important preparation for the study of vertebrate cell lineage and developmental biology. (On-line Medical Dictionary)
C14288	Feline_Immunodeficiency_Virus	Lentivirus	Feline Immunodeficiency Virus|FIV	A lentivirus causing acquired immunodeficiency in cats. The FIV virus is transmitted in the saliva or blood, commonly through the bite wound from an infected cat. Strictly a feline disease, FIV cannot be transmitted to humans.
C14289	Helicobacter_pylori	Helicobacter	Helicobacter pylori|H. pylori	Bacteria that cause stomach inflammation (gastritis) and ulcers in the stomach. This bacteria is the most common cause of ulcers worldwide. It is often referred to as H. pylori. H. pylori infection is usually acquired from contaminated food and water and through person to person spread. The infection is common in crowded living conditions with poor sanitation. In countries with poor sanitation, 90% of the adult population can be infected. In the U.S., 30% of the adult population is infected. One out of six patients with H. pylori infection develops ulcers of the duodenum or the stomach. This bacteria is also believed to be associated with stomach cancer and a rare type of lymph gland tumor called gastric MALT lymphoma. Infected persons usually carry the infection indefinitely, unless treated with medications to eradicate the bacteria. (MedicineNet.com)
C14290	Lentivirus	Retroviridae	Lentivirus|Virus-Lenti	A genus of the family Retroviridae consisting of non-oncogenic retroviruses that produce multi-organ diseases characterized by long incubation periods and persistent infection. Lentiviruses are unique in that they contain open reading frames (ORFs) between the pol and env genes and in the 3' env region. Five serogroups are recognized, reflecting the mammalian hosts with which they are associated. HIV-1 is the type species.
C14291	Betaretrovirus	Retroviridae	Betaretrovirus|Retroviruses, Type B, Mammalian|Type B Mammalian Retrovirus|Type B Virus|Type D Retrovirus
C14292	Type_D_Retrovirus	Retired_Concepts	Type D Retrovirus	contains several isolates of exogenous, horizontally transmitted and endogenous viruses of new and old world primates; associated with immunodeficiency diseases.
C14293	Spumavirus	Retroviridae	Spumavirus
C14294	SCID_Mouse	Immunodeficient_Mouse	SCID Mouse|SCID|severe combined immune deficiency	Severe combined immunodeficient (SCID) mice like their human counterparts with immunodeficiency diseases are helpless not only to fight infection but also to reject transplanted tissue. These animals lack both T and B-cells and are used extensively in researches of immune disease or tissue transplantation.
C14295	Hepatitis_E_Virus	Calicivirus|Hepatitis_Virus	Hepatitis E Virus|HEV
C14296	Helicobacter	Bacteria	Helicobacter	Helicobacter. A genus of gram-negative helical, curved, or straight microaerophilic bacteria with rounded ends and multiple sheathed flagella (unipolar or bipolar and lateral) with terminal bulbs. Form nonpigmented, translucent colonies, 1-2 mm in diameter. Catalase and oxidase positive. Found in gastric mucosa of primates, including human beings and ferrets. Some species are associated with gastric and peptic ulcers and gastric cancer. The type species is Helicobacter pylori.
C14297	Chimpanzee	Primate	Chimpanzee|Chimp|Common Chimpanzee|Pan Species|Pan troglodytes	Pan troglodytes, an anthropoid ape that inhabits the tropical rain forests of Africa and is used for experimental purposes because of its susceptibility to some human diseases and in behavioral studies because of its high level of intelligence.
C14298	HTLV_Virus	Retired_Concepts	HTLV Virus|Virus-HTLV-Unspecified	Generic category for HTLV-I and HTLV-II.
C14299	Parvovirus	Single_Stranded_DNA_Virus	Parvovirus	A family of very small DNA viruses containing a single linear molecule of single-stranded DNA and consisting of two subfamilies: PARVOVIRINAE and DENSOVIRINAE. They infect both vertebrates and invertebrates.
C14300	Rous_Sarcoma_Virus	Alpharetrovirus	Rous Sarcoma Virus|RSV	produces fibrosarcomas in fowl, especially chickens; some strains may produce tumors in other animals.
C14301	Bacteriophage_P1	Bacteriophage	Bacteriophage P1	temperate tailed phagae; does not integrate into host chromosome; prophage resembles plasmid and replicates autonomously at low numbers.
C14302	Bacteriophage_T4	Bacteriophage	Bacteriophage T4	tailed phage, isolated from E. coli.
C14303	Caenorhabditis_elegans	Nematodes	Caenorhabditis elegans|C. elegans	A roundworm of the phylum Nematoda often utilized as a biological model system for research.
C14304	Calicivirus	ssRNA_Virus_plus_Strand	Calicivirus
C14305	Gammaretrovirus	Retroviridae	Gammaretrovirus|Retroviruses, Type C, Mammalian|Type C Mammalian Retrovirus
C14306	Arenavirus	ssRNA_Virus_Strand	Arenavirus
C14307	Paramyxovirinae	Paramyxoviridae	Paramyxovirinae	The subfamily of Paramyxoviridae which includes Mumps and Measles viruses.
C14308	Pneumovirinae	Paramyxoviridae	Pneumovirinae	A subfamily of Paramyxoviridae which includes human respiratory syncytial virus.
C14309	Morbillivirus	Paramyxovirinae	Morbillivirus	A genus of Paramyxovirinae which includes Measles Virus
C14310	Paramyxovirus	Paramyxovirinae	Paramyxovirus|paramyxovirus	A type of virus that has hemagglutinin-neuraminidase proteins in the outer coat and RNA as the genetic material.  Measles (rubeola) virus, mumps virus, and Newcastle disease virus are paramyxoviruses.
C14311	Herpes_Simplex_Virus	Herpesvirus	Herpes Simplex Virus|HSV	HSV is a nuclear replicating, icosahedral, enveloped DNA virus. The HSV envelope contains at least 8 glycoproteins. The matrix or tegument which contacts both the envelope and the capsid contains at least 15-20 proteins. There are two types of HSV - Type 1 and Type 2.  The Type 1 virus causes cold sores.  Most people get Type 1 infections during infancy or childhood. The Type 2 virus causes genital sores. Most people get Type 2 infections following sexual contact with an infected person.
C14312	Hepatitis_C_Virus	Flavivirus|Hepatitis_Virus	Hepatitis C Virus|HCV|Hepatitus C|Virus-Hepatitis C	an RNA virus which has been shown to be the major etiologic agent of non-A non-B hepatitis and causes substantial morbidity and mortality worldwide; also associated with cirrhosis and hepatocellular carcinoma.
C14313	Equidae	Mammal	Equidae	Taxonomic family which includes horses, zebras, and asses.
C14314	SENCAR_Mouse	Laboratory_Animal	SENCAR Mouse	Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also hypersusceptible to UV radiation tumorigenesis with single high-dose, but not chronic low-dose, exposures. SENCAR (SENsitive to CARcinogenesis) mice are used in research as an animal model for tumor production. (MeSH)
C14315	Canarypox_Virus	Poxvirus	Canarypox Virus	A poxvirus of the genus Avipoxvirus.  Has been adapted as a cloning vector (canarypox vector) for use as a mammalian expression vector.
C14316	Infectious_Agent	Other_Organism_Groupings	Infectious Agent|Infectious Agents	Any organism, such as a pathogenic virus, parasite, or or bacterium, that is capable of invading body tissues, multiplying, and causing disease. (EPA Terminology Reference System)
C14317	Human_Virus	Other_Virus_Grouping	Human Virus|Viruses, Human	Viruses which routinely infect humans
C14318	Ovine_Jaagziekte_Virus	Herpesvirus	Ovine Jaagziekte Virus|Sheep Pulmonary Adenomatosis Virus	A herpesvirus of sheep associated with pulmonary adenomatosis
C14319	Human_Papillomavirus-6	Human_Papillomavirus	Human Papillomavirus-6|HPV-6|Human Papillomavirus Type 6	Genital warts caused by HPV 6 and 11 are the most common STD in the United States. Over a million cases are seen per year.
C14320	Poikilotherms	Animal	Poikilotherms	Animals which have a body temperature which is largely controlled by external factors of the environment.
C14321	Felidae	Mammal	Felidae|Felids	Taxonomic family which includes domestic and wild cats such as lions and tigers.
C14322	Suidae	Mammal	Suidae	Taxonomic family which includes the domestic pig
C14323	Bovidae	Mammal	Bovidae	Taxonomic family which includes domestic cattle, goats, and sheep.
C14324	Virus-like_Particle	Virus	Virus-like Particle|VLP
C14325	Hepatitis_A_Virus	Hepatitis_Virus|Picornavirus	Hepatitis A Virus|HHVA|Human Hepatitis A Virus	A single stranded RNA virus.  A member of the picornaviridae family, subfamily hepatovirus.  The causative agent of Hepatitis A.
C14326	Rubulavirus	Paramyxovirinae	Rubulavirus	A genus of Paramyxovirinae which includes Mumps Virus
C14327	Human_Herpesvirus_8	Herpesvirus	Human Herpesvirus 8|HHV-8|HHV8|KSHV|Kaposi Sarcoma-Associated Herpes Virus|Virus-HHV8	A gammaherpesvirus that contributes to the development of Kaposi sarcoma.
C14328	Hepatitis_G_Virus	Flavivirus|Hepatitis_Virus	Hepatitis G Virus|GB virus C|GBV-C|HGV|Hepatitis GB virus C	B strain causes hepatitis in tamarins and possibly humans; putative etiological agent of GB hepatitis.
C14329	Microorganism	Other_Organism_Groupings	Microorganism|Microorganisms|Microorganisms, General|microorganism	An organism that can be seen only through a microscope. Microorganisms include bacteria, protozoa, algae, and fungi. Although viruses are not considered living organisms, they are sometimes classified as microorganisms.
C14330	Helicobacter_felis	Helicobacter	Helicobacter felis|H. felis
C14331	Canidae	Mammal	Canidae	Taxonomic family which includes the domestic dog, wolves and foxes.
C14332	Avian_Leukemia_Sarcoma_Virus	Alpharetrovirus	Avian Leukemia Sarcoma Virus|ALSV-A	A type C avian retrovirus
C14333	Marine_Organism	Other_Organism_Groupings	Marine Organism	Any organism that lives in the sea
C14334	Endogenous_Retrovirus	Other_Virus_Grouping	Endogenous Retrovirus|ERV	Genetic elements propagated primarily through the germline, with a proviral structure, i.e. the chromosomally-integrated form of retroviruses and regulated by cellular processes.  Could be involved in development and serve as progenitors to pathogenic retroviruses.  Classified as ecotropic or xenotropic.  Ecotropic viruses can be transmitted to cells of the same species and can produce malignancies. Xenotropic viruses cannot infect cells from their host species but are infectious in heterologous species.  Cycles of transcription and reverse transcription make the elements mobile and mutagenic.
C14336	Vascular_Plant	Plant	Vascular Plant|Higher Plant|Plants, Vascular	The flowering herbs, shrubs, trees and ferns.  These plants have vascular tissue, consisting of xylem, which carries water and nutrients from the roots up the stem to the leaves, and the phloem, which carries sugar produced in the leaves to other parts of the plant.
C14337	Bovine_Papillomavirus-1	Bovine_Papillomavirus	Bovine Papillomavirus-1|BPV-1	A type of Bovine Papilloma Virus
C14338	Human_Papillomavirus-16	Human_Papillomavirus	Human Papillomavirus-16|HPV-16	A strain of the human papillomavirus virus, (HPV16), has been directly linked to cervical cancer and is significantly associated with invasiveness. The papillomavirus virus constitutes a protein coat (capsid) surrounding a circular, double-stranded DNA organised into coding and non-coding regions, and induces skin and mucosal epithelial lesions. Progression from low- to high-grade neoplasia is often associated with the integration of the HPV16 virus genome into the host chromosome. The event occurs with disruption or deletion of the E2 ORF followed by inactivation of the E2 regulatory protein.
C14339	Knock-Out_Mouse	Transgenic_Mouse	Knock-Out Mouse|Knockout Mouse|Mouse, Knockout|Null Mouse	Informal term for the generation of a mutant mouse in which the function of a particular gene has been completely eliminated, also called a null mouse.
C14340	Non-Vascular_Plant	Plant	Non-Vascular Plant|Bryophyte|Plants, Non-Vascular	A plant that does not have vascular tubes/tissues to transport food and water.  It belongs to the division Bryophyta, which includes liverwort, and moss.
C14341	Primate_Retrovirus	Other_Virus_Grouping	Primate Retrovirus	An RNA containing virus infecting primates (SIV, STLV, SFV).
C14342	PVC-211_MuLV	Mouse_Leukemia_Virus	PVC-211 MuLV	A murine leukemia virus (MuLV) variant cloned from rats infected with the Friend leukemia virus.  Neuropathogenic, causes hind limb paralysis in rats and mice, unlike the parent Friend virus which causes erythroleukemia.
C14343	Non-Human_Immunodeficiency_Virus	Retired_Concepts	Non-Human Immunodeficiency Virus|Retroviruses, Non-Human Immunodeficiency Virus
C14344	Sloan_Kettering_Virus	Alpharetrovirus	Sloan Kettering Virus|SKVS	The Sloan-Kettering viruses (SKVs) are a group of transforming retroviruses that were isolated from chicken embryo cells which had been infected with the avian leukosis virus transformation-defective Bratislava 77 (tdB77). (from Li et al.  J Virol 1986;57:1065-72)
C14345	TGF-Beta-Null_Mice	Knock-Out_Mouse	TGF-Beta-Null Mice
C14346	ssRNA_Virus_Strand	RNA_Virus	ssRNA Virus, (-) Strand|(-) Strand ssRNA Virus	A single stranded RNA virus where the RNA strand is the complement of a mRNA.
C14347	Deltaretrovirus	Retroviridae	Deltaretrovirus|BLV-HTLV Retrovirus	A genus in the family retroviridae consisting of exogenous horizontally transmitted viruses found in mammals; associated with B or T cell leukemia/lymphoma with a long latency. Bovine Leukemia Virus is the type species. (from CRISP)
C14348	Double_Stranded_DNA_Virus	DNA_Virus	Double Stranded DNA Virus|dsDNA Virus
C14349	Other_Virus_Grouping	Virus	Other Virus Grouping
C14350	Single_Stranded_DNA_Virus	DNA_Virus	Single Stranded DNA Virus|ssDNA Virus
C14351	ssRNA_Virus_plus_Strand	RNA_Virus	ssRNA Virus, (+) Strand	A single stranded RNA virus where the RNA strand has the same polarity as a mRNA.
C14352	Consomic_Strain	Laboratory_Animal	Consomic Strain|Chromosome Substitution Strain|Consomic Strain/Chromosome Substitution Strain	Strains derived by repeated backcrossing while maintaining one whole chromosome genetically different from the background strain. (JAX IMSR glossary)
C14353	Recombinants	Laboratory_Organism	Recombinants	An individual cell or organisms which carries recombinant DNA
C14354	Laboratory_Organism	Other_Organism_Groupings	Laboratory Organism|Experimental Organism
C14355	Agents_of_Opportunistic_Infection	Infectious_Agent	Agents of Opportunistic Infection	Infectious agents, which while normally present but remaining benign under the control of the immune system, become virulent and pathogenic in immune-compromised hosts (i.e when they get the opportunity to become infectious).
C14356	Infectious_Agent_Bacteria	Infectious_Agent	Infectious Agent, Bacteria
C14357	Infectious_Agent_Virus	Infectious_Agent	Infectious Agent, Virus
C14358	Leporidae	Mammal	Leporidae	Taxonomic family which includes rabbits and hares
C14359	Invertebrates_Land	Invertebrate	Invertebrates, Land	Terrestrial animals without back bones
C14360	Invertebrates_Marine	Invertebrate|Marine_Organism	Invertebrates, Marine	Animals without a backbone that live in the ocean
C14361	Foamy_Retrovirus	Spumavirus	Foamy Retrovirus	A species of spumavirus.
C14362	Friend_Murine_Leukemia_Virus	Mouse_Leukemia_Virus	Friend Murine Leukemia Virus|CFV|Friend Leukemia Virus|Friend Leukemia Virus, Conventional	A murine leukemia virus producing leukemia of the reticulum-cell type with massive infiltration of liver, spleen, and bone marrow. It infects DBA/2 and Swiss mice.
C14363	NSF_N_Mice	Laboratory_Animal	NSF/N Mice
C14364	Herpes_Genital_Virus	Viral_Infection	Genital Herpes	Herpes simplex infection on the genitals, most commonly caused by the herpes simplex-1 virus.
C14365	Congenic_Strain	Laboratory_Animal	Congenic Strain	Congenic strains are produced by transferring a mutation from one genetic background to a specific inbred strain through repeated backcrossing. The congenic strain and the inbred partner are expected to be identical at all loci except for the transferred locus and a linked segment of chromosome. The size of the segment and the possibility of transferred alleles on other chromosomes depend on the number of backcross generations. A strain is considered fully congenic after ten generations of backcrossing (N10). (from JAX Strain Information)
C14366	Man	Human	Man|Human, Male	A man is an adult, male human.
C14367	Latent_Virus	Other_Virus_Grouping	Latent Virus	Virus integrated within host genome but inactive: may be reactivated by stress such as ultraviolet irradiation.
C14368	Lytic_Virus	Other_Virus_Grouping	Lytic Virus	A virus which, as part of its life cycle, causes its host cells plasma membrane to rupture (to lyse).
C14369	Lower_Organism	Other_Organism_Groupings	Lower Organism|Lower Organisms	A subjective term that might be applied to any non-human organism.
C14370	Sexually_Transmitted_Agents	Infectious_Agent	Sexually Transmitted Agents
C14371	Oncornavirus	Tumor_Virus	Oncornavirus|RNA Tumor Virus	An informal grouping of rna-containing viruses that are capable of inducing tumors.
C14372	Inbred_Recombinant_Congenic_Mouse_Strains	Congenic_Strain|Recombinant_Inbred_Strain	Inbred Recombinant Congenic Mouse Strains
C14373	Consomic_Mouse_Strain	Consomic_Strain	Consomic Mouse Strain	Strains of mice derived by repeated backcrossing while maintaining one whole chromosome genetically different from the background strain. (JAX IMSR glossary)
C14374	Recombinant_Inbred_Strain	Laboratory_Animal	Recombinant Inbred Strain	Recombinant inbred (RI) strains are derived by systematic inbreeding from the cross of two pre-existing progenitor strains. (from JAX Strain Information)
C14375	Escape_Mutant	Human_Immunodeficiency_Virus	Escape Mutant	HIV mutants which have overcome drug inhibition.
C14376	Other_Organism_Groupings	Organisms	Other Organism Groupings
C14377	Human_Papillomavirus-18	Human_Papillomavirus	Human Papillomavirus-18|HPV-18	A strain of the human papillomavirus virus, (HPV18), has been directly linked to cervical cancer and plays a role in the pathogenesis of the disease. The papillomavirus virus constitutes a protein coat (capsid) surrounding a circular, double-stranded DNA organised into coding and non-coding regions, and induces skin and mucosal epithelial lesions. The virus integrates its DNA at specific chromosomal locations, such as 8q24 and 12q15, which harbours both HPV18 and HPV16. The use of molecular markers such as HPV18 DNA type may allow the identification of patients with early stage cervical cancer at high risk for disease recurrence.
C14378	Corynebacterium_parvum	Bacteria	Corynebacterium parvum|C. parvum|CP|CPAR|CParv|Propionibacterium acnes
C14379	Mistletoe	Vascular_Plant	Mistletoe	Mistletoe is the common name for various evergreen parasitic plants of the families Loranthaceae and Santalaceae (or Viscaceae), especially "European mistletoe" Viscum album and "American mistletoe" Phoradendron flavescens, with waxy white berries and smooth-edged oval leaves in pairs along the woody stem.  The extract is being studied for its potential use in cancer treatment.
C14380	WN_Rat_Strain	Common_Rattus_Norvegicus_Strains	WN, Rat Strain|WN	Anterior pituitary tumors nearly 100% in females over 18 months of age, pheochromocytomas or preneoplastic nodules in adrenal medulla about 40% in males, granulocytic leukemia 14% in animals over 18 months of age. Rarely show hyperplastic cortical nodules or adrenal cortical adenomas. High incidence of severe chronic nephritis. (Snell 1967). High 10-week body weight in males (19/23), and high relative heart weight in 10-week old males (19/23) (Tanase et al 1982).
C14381	SD_Rij_Rat_Strain	Common_Rattus_Norvegicus_Strains	SD/Rij, Rat Strain	Less sensitive to the induction of mammary tumors by DMBA than two samples of outbred Sprague-Dawley rats; mean life-span 743-22 days.
C14382	OM_Rat_Strain	Common_Rattus_Norvegicus_Strains	OM, Rat Strain	Spontaneous thyroid carcinoma 33% (Lindsey et al 1968). Adrenal cortical tumors 94% and pituitary tumors 8-18% at 18 months (Hansen et al 1973). In animals over 18 months Snell found adenomas or carcinomas of adrenal cortex 73% in males and 95% in females, pituitary tumors 25%, granulosa cell tumors of the ovary 33% in females. High blood pressure (3/23), reaching 154+/-1.0 (SEM) mmHg at 10 weeks of age (Tanase et al 1982). Mammary tumors 26-30%. High incidence of retinal degeneration in animals over 10 months (von Sallman and Grimes 1972, 1974). High systolic blood pressure (2/17) (Hansen et al 1973).
C14383	LOU_C_Rat_Strain	Common_Rattus_Norvegicus_Strains	LOU/C, Rat Strain	Develop spontaneous plasmacytomas after about 8 months of age, with an incidence of about 30% in males and 16% in females. These develop rapidly, and may be detected by palpation. They usually develop in the ileocoecal lymph nodes, and about 60% of them synthesis monoclonal immunoglobulins (Bence-Jones proteins) of IgG1 (35%), IgE (36%) or IgA classes.
C14384	HMT_Rat_Strain	Common_Rattus_Norvegicus_Strains	HMT, Rat Strain	About 50% incidence of squamous-cell carcinoma of the mouth late in life. Mean life-span 27-30 months with or without mouth tumors (Hulse 1979, Buckley et al 1980).
C14385	DA_Rat_Strain	Common_Rattus_Norvegicus_Strains	DA, Rat Strain	DA: Urinary bladder tumors 54% in males and 14% in females, with a peak incidence at 25-30 months of age (Deerberg et al 1985). High incidence of hormone-dependent endometrial adenocarcinoma. A transplantable cell line (RUCA-I) derived from such a tumor in DA rats can produce these tumors in ectopic sites. The rate of proliferation is reduced by tamoxifen, and this cell line appears to be a suitable model for the study of molecular aspects of estrogen and tamoxifen-dependent gene expression.
C14386	BDVI_Rat_Strain	Common_Rattus_Norvegicus_Strains	BDVI, Rat Strain	About 4% of spontaneous peripheral nerve tumors, with cystic schwannomas being the most frequent type. 24 spontaneous and 28 ethylnitrosourea-induced tumors has been described by Turusov and Cabral, (1994).
C14387	BDIX_Rat_Strain	Common_Rattus_Norvegicus_Strains	BDIX, Rat Strain	Strain widely used in carcinogenesis and teratogenesis studies. Highly susceptible to the transplacental induction of malignant tumors of the central nervous system by ethyl nitrosourea (Druckrey et al 1970). A transplantable monocytic-myeloid leukemia L5222 induced by ethyl nitrosourea has been used as a model for chemotherapy (Ivankovic and Zeller 1974). Transplantable colon tumor PROb grows progressively and metastasizes, whereas REGb grows slowly and is then rejected (Blottiere et al 1992a,b).
C14388	BDII_Rat_Strain	Common_Rattus_Norvegicus_Strains	BDII, Rat Strain	Frequent microphthalmia. Genetic markers described for sublines of this strain in the USA differ from those in Europe, suggesting that the US sublines were contaminated at some time in the past with LEW (Czerwinski and Crowell 1986). Mean life-span of BDII/Han 33.6 +/-4.7 months in males and 22.5+/-4.4 months in females, with 91% of females developing endometrial carcinomas, but with a more varied range of tumors in males. These include 26% adrenal pheochromocytomas, 23% histiocytic sarcomas, 18% pituitary tumors and 14% hemangiomas. About 12% of aged male BDII/Han develop diverticula of the stomach (Kaspareit-Rittinghausen and Deerberg 1987). High incidence of hormone-dependent endometrial adenocarcinoma.
C14389	A990_Rat_Strain	Common_Rattus_Norvegicus_Strains	A990, Rat Strain	Resistant to Cysticercus. Susceptible to estrogen-induced mammary and adrenal tumors. Good reproduction. High open-field defecation (2/12, males, 3/12 females) and low ambulation (11/12), Harrington (1972). Low wheel activity (12/12) (Harrington 1971b). Aggressive towards handlers (Harrington 1981).
C14390	WF_Rat_Strain	Common_Rattus_Norvegicus_Strains	WF, Rat Strain	In females tumors include 27% pituitary, 21% mammary, 3% adrenal, 9% leukemia (generalized), 7% lymphoma (malignant), 3% lipomas and 4% unclassified (Kim et al 1960). Mean life span 21 months in females and 23 months in males. Leukemia 15-22% characterised by an unusual type of mononuclear cell containing reddish granules. Incidence of spontaneous pituitary tumors 38% in rats older than 10 months of age, increasing to a maximum of 69% at 28-32 months of age. Higher incidence in females (71%) than in males (35%)
C14391	W_Nhg_Rat_Strain	Common_Rattus_Norvegicus_Strains	W/Nhg, Rat Strain	High incidence (97% in females, 36% in males) of spontaneous thymomas starting from about one year of age. They sometimes caused dyspnea, and were occasionally the cause of death, but were not associated with any myopathies or autoimmune disease (Murray et al 1985).
C14392	ACI_Rat_Strain	Common_Rattus_Norvegicus_Strains	ACI, Rat Strain	Median survival 113 weeks in males, 108 weeks in females. Spontaneous tumors 46% testes, 16% adrenal, 5% pituitary, 6% skin and ear duct and fewer of other types in males; 21% pituitary, 13% uterus, 11% mammary gland, 6% adrenal and fewer of other types in females.  Will grow transplantable Morris hepatomas 3924A which can be used as a model for the treatment of liver cancer (Yang et al 1995).
C14393	A28807_Rat_Strain	Common_Rattus_Norvegicus_Strains	A28807, Rat Strain	Very docile. Susceptible to the induction of autoimmune thyroiditis. Low and intermediate antibody responses to 1 and 10 g BSA, respectively. Low antibody response to streptococcal group A carbohydrate; not linked to the MHC. High relative heart weight in 10-week old males (20/23).
C14394	BB_Rat_Strain	Common_Rattus_Norvegicus_Strains	BB, Rat Strain	BB: The development of lymphocytic thyroiditis is not affected by iodine treatment according to Allen (1992), though Ebner et al (1992) found the opposite. Epitope specificities of collagen-induced arthritis studied by Cremer et al (1992). A lymphopenic, nondiabetic substrain BB-DR has very low T-cell numbers, depressed B-lymphocyte numbers and a complete absence of peripheral CD8+ T cells characteristics of the susceptible BB strain(Joseph et al 1993). Transfusing of BB-DR thymocytes into nude rats transfers the autoimmune insulin-dependent diabetes mellitus (Whalen et al 1995).
C14395	BN_Rat_Strain	Common_Rattus_Norvegicus_Strains	BN, Rat Strain	BN: Tumors of epithelium 28% in males, 2% in females. Ureter tumors 20% in females, 6% in males. Most common neoplastic lesions in males were urinary bladder carcinoma 35%, pancreas islet adenoma 15%, pituitary adenoma 14%, lymphoreticular sarcoma 14%, adrenal cortex adenoma 12%, medullary thyroid carcinoma 9%, adrenal pheochromocytoma 8%. Four other types of tumors were observed. In females: pituitary adenoma 26%, ureter carcinoma 22%, adrenal cortical adenoma 19%, cervix sarcoma 15%, mammary gland fibroadenoma 11%, islet adenoma 11%. Twelve other tumor types were observed (Burek and Hollander 1975a).
C14396	BUF_Rat_Strain	Common_Rattus_Norvegicus_Strains	BUF, Rat Strain	BUF: Low incidence of dental caries. Spontaneous tumors of anterior pituitary 30%, and of adrenal cortex 25% in older animals. Survival 58% at 2 years of age with thyroid carcinoma in 25% (Lindsey et al 1968). Low incidence of renal neoplasms (Snell 1967). High incidence of tumors of the anterior pituitary, adrenal medulla and adrenal cortex in animals over 18 months old (Snell1965).
C14397	COP_Rat_Strain	Common_Rattus_Norvegicus_Strains	COP, Rat Strain	Spontaneous tumors of the thymus (Dunning and Curtis 1946, Dunning et al 1947)
C14398	CRDH_Rat_Strain	Common_Rattus_Norvegicus_Strains	CRDH, Rat Strain	Non-insulin-dependent overt diabetes: blood glucose 384+/- 134 mg/dl (plasma insulin at 60 min following intragastric glucose load 83.3 +/-10.2mU/mL) and hypertension blood pressure 176 +/-8mmHg. There was severe diffuse diabetic glomerulosclerosis and severe hypertensive changes in arteries and arterioles characterised by fibrinoid necrosis and/or onion skin lesions as well as smooth muscle hyperplasia. Myocardial changes were prominent, with foci of ischemic necrosis and hyperplastic vascular changes.
C14399	DONRYU_Rat_Strain	Common_Rattus_Norvegicus_Strains	DONRYU, Rat Strain	DONRYU: Spontaneous tumors 74% in males at 120-weeks, mostly pituitary adenomas, pheochromocytomas and insulinomas. In females incidence 89%, mostly uterine adenocarcinomas, mammary fibroadenomas and pituitary adenomas.
C14400	E3_Rat_Strain	Common_Rattus_Norvegicus_Strains	E3, Rat Strain	Has platelet storage disease associated with the red-eyed yellow locus, as described by Raymond and Dodds (1975) for the FH strain.
C14401	F344_Rat_Strain	Common_Rattus_Norvegicus_Strains	F344, Rat Strain	Most animals older than 2 years exhibit small local areas of nephritis; less than 25% show severe nephritis (Snell 1967). Tumors: Mammary tumors 41% in females and 23% in males, pituitary adenomas 36% in females and 24% in males, testicular interstitial cell tumors 85% in males. Other tumor types less common (Sass et al 1975). Thyroid carcinoma 22% (Lindsey et al 1968). Interstitial cell testicular tumors 65%, mononuclear cell leukemia 24%, subcutaneous fibroadenoma 9% in females. Both sexes have a 5% incidence of nodular hyperplasia of the liver.
C14402	FH_Rat_Strain	Common_Rattus_Norvegicus_Strains	FH, Rat Strain	It has been suggested that FH rats represent a genetic model of depression They have altered serotonergic function (Aulka et al, 1994a), they exhibit differential responses to serotonin agonists and antagonists compared with other strains (Meehan and Schechter, 1994), and long-term treatment with imipramine, clomipramine and clorgyline produced significant decreases in plasma corticosterone levels, supporting this suggestion (Aulka et al, 1993).
C14403	FHH_Rat_Strain	Common_Rattus_Norvegicus_Strains	FHH, Rat Strain|Fawn Hooded Hypertension	Origin: An outbred stock of fawn hooded rats introduced into Europe by Tschopp in the early 1970s. Maintained as an outbred stock until the mid-1980s, then brother x sister mating initiated by A.P. Provoost to produce two strains designated FHH (also known as FHR) and FHL, which differ in hypertension and proteinuria.  FHH develops focal and segmental glomerular sclerosis, systemic hypertension and proteinuria at a young age, but these effects are more marked in FHH than FHL (Simons et al, 1993). The renal disease and hypertension are under independent genetic control, and both appear to be independent of the red-eyed dilution gene which causes platelet storage disease (Brown et al,1996)
C14404	GH_Rat_Strain	Common_Rattus_Norvegicus_Strains	GH, Rat Strain	GH: Develops hypertension, cardiac hypertrophy and vascular disease (Phelan 1968, Simpson and Phelan 1984, Simpson et al, 1994). Genetic hypertension in GH (but not SHR) may be associated with a defect in renal prostaglandin catabolism (Armstronag et al 1976).
C14405	IR_Rat_Strain	Common_Rattus_Norvegicus_Strains	IR, Rat Strain	Vigorous and healthy, but high incidence of physical abnormalities. Skulls of young fragile through weaning. High death rate from hemorrhage due to blood platelet disease (Harrington 1981). Long latency to emerge into familiar environment (12/12 males, 10/12 females) (Harrington 1971a). High open field exploration in females (3/12) (Harrington 1972). Low wheel activity (11/12 males10/12 females) (Harrington 1971b).
C14406	LEC_Rat_Strain	Common_Rattus_Norvegicus_Strains	LEC, Rat Strain	Carries a mutation causing fulminated hepatitis and jaundice at about four months of age. Clinical symptoms include severe jaundice, bleeding, oliguria, loss of body weight and elevation of serum levels of bilirubin and hepatic enzymes. About half the animals die within a week of onset, and in survivors hepatocellular carcinoma spontaneously appears after 1-1.5 years (Kasai et al 1990,Sasaki 1985, Wirth et al 1990).
C14407	LEW_Rat_Strain	Common_Rattus_Norvegicus_Strains	LEW, Rat Strain	Of the large spectrum of 52 histologically different types of tumors, the highest incidence was observed for adenomas of the pituitary and adenomas/adenocarcinomas of the adrenal cortex in both sexes, mammary gland tumors and endometrial carcinomas (45%) in females, and C-cell adenomas/adenocarcinomas of the thyroid gland and tumors of the hemopoietic system (28%) in males (Baum et al, 1995).
C14408	LH_Rat_Strain	Common_Rattus_Norvegicus_Strains	LH, Rat Strain	LH: The strain exhibits mild hypertension (approx 165mmHg in males and 140mmHg in females at 14 weeks of age in 1984) with increased body weight and plasma lipids. There is reduced life-span (compared with LN and LL) with histopathological lesions characteristic of hypertensive disease in rats.
C14409	M520_Rat_Strain	Common_Rattus_Norvegicus_Strains	M520, Rat Strain	Low frequency of pancreatic exocrine tumours. By 12-15 months of age develop small local areas of nephritis that progress by 22-24 months to moderate to severe nephritis in 75% of animals (Snell 1967). About 33% of females over 18 months develop tumours of the uterus of endometrial origin. Adrenocortical adenomas (about 20% in males and 40% in females over 18 months of age), and phaeochromocytomas or preneoplastic nodules in adrenal medulla (about 67% of males over 21 months of age) (Snell 1965). Low blood pressure (21/23), reaching 121_1.2 (SEM) mmHg at 10 weeks of age. Resistant to development of methylcholanthrene -induced thyroiditis (Glover et al 1969).
C14410	NBL_Rat_Strain	Common_Rattus_Norvegicus_Strains	NBL, Rat Strain	Good reproductive performance. Hyperplasia and dysplasia of the dorsolateral prostate caused by implantation of testosterone and estradiol-17-filled silastic capsules. Prolonged implantation leads to prostatic carcinoma (Leav et al 1988, 1989).
C14411	NZR_Rat_Strain	Common_Rattus_Norvegicus_Strains	NZR, Rat Strain	Tumors (atriocaval epithelial mesotheliomas) of right atrium or inferior vena cava occur in approximately 12-20% of animals of both sexes over 1 year. These tumors are slow growing, but apparently malignant, and closely resemble similar tumors found in humans (Goodall et al 1975). In a later study, most common neoplasms of animal over one year of age: atrioclaval mesotheliomas 12%, lung adenomas 10% (males), pituitary adenomas 23%, mammary tumors 7%, liver tumors 3%, cervical tumors 3% (in females) (Goodall and Doesburg 1981).
C14412	SHR_Rat_Strain	Common_Rattus_Norvegicus_Strains	SHR, Rat Strain	SHR: rats develop hypertension spontaneously without exception at the age of 7-15 weeks. There is a systolic blood pressure plateau of about 200 mmHg. The genetic basis is polygenic, with at least three major genes involved (Tanase and Suzuki 1971, Yen et al 1974). There is a high incidence of cardiovascular disease (Okamoto et al 1973), but a low incidence of stroke which can be increased to about 30% with chronic stress (Yamori 1984).
C14413	OXYS_Rat_Strain	Common_Rattus_Norvegicus_Strains	OXYS, Rat Strain	Inherited overproduction of free radicals, high levels of lipid peroxidation, protein oxidation, DNA rearrangements, morbid conditions mimicking human degenerative diseases: cataract, emphysema, cardiomyopathy, carcinogenesis; short life-span and low fecundity. Intensive transport of monosaccharides into the cells (Salganik et al 1994).
C14414	WAG_Rat_Strain	Common_Rattus_Norvegicus_Strains	WAG, Rat Strain	Tumors: medullary thyroid carcinoma 27%, chromophobe adenoma of the pituitary 68%, adrenal cortical adenoma 29%, pheochromocytoma 2%, islet cell adenoma 1%. Mean life-span more than 31 months in females and 22 months in males (Boorman et al 1972). Mean life-span 31 months in females with pituitary tumors found in 69% of females. Other common tumors include medullary thyroid carcinoma 40%, adrenal cortical adenoma 29%, fibroadenoma of breast 21% with 19 other types of tumor found in 290 animals (Boorman and Hollander 1973).
C14415	OM_N_substrain	OM_Rat_Strain	OM/N, substrain
C14416	Abelson_Murine_Leukemia_Virus	Mouse_Leukemia_Virus	Abelson Murine Leukemia Virus|A-MuLV
C14417	Rat_Strains	Organism_Strains	Rat Strains|Common Rat Strains
C14418	Wild_Type_Mouse	Mouse_Strains	Wild Type Mouse
C14419	Organism_Strains	Organisms	Organism Strain|Organism Strains|Strain	A population or type of organisms that is geneticaly different from others of the same species and possessing a set of defined characteristics.
C14420	Mouse_Strains	Organism_Strains	Mouse Strains
C14421	Inbred_Mouse	Mouse_Strains	Inbred Mouse
C14422	FVB	Retired_Concepts	FVB
C14423	_129Sv_ImJ	Retired_Concepts	129Sv/ImJ
C14424	C57BL_6	Inbred_Mouse	C57BL/6 Mouse|B6|C57BL/6
C14425	Swiss_Mice_sdc	Retired_Concepts	Swiss Mice (sdc)|Swiss
C14426	CJ_Lynch_Rockefeller_Inst_1926	Retired_Concepts	CJ Lynch 1926 Rockefeller Inst|CJ Lynch Rockefeller Inst 1926
C14427	SWR_J_Mouse	Inbred_Mouse	SWR/J Mouse|SWR/J
C14428	LT_Webster_1932_sdc	Retired_Concepts	LT Webster 1932 (sdc)
C14429	CJ_Lynch_1926_plus_LT_Webster_1932_Mouse	Retired_Concepts	CJ Lynch 1926+LT Webster 1932 Mouse|CJ Lynch 1926+LT Webster 1932|Lynch+Webster
C14430	Da_HuSn_Mouse	Retired_Concepts	Da/HuSn Mouse|Da/HuSn
C14431	Castle_Strains	Retired_Concepts	Castle Strains
C14432	Swiss_Strains	Retired_Concepts	Swiss Strains
C14433	China_and_Japan_Colony_Strains	Retired_Concepts	China and Japan Colony Strains
C14434	C57-related_Strains	Retired_Concepts	C57-related Strains
C14435	Multiple_Inbred_Strains	Retired_Concepts	Multiple Inbred Strains
C14436	Wild_Mice_Strains	Retired_Concepts	Wild Mice Strains
C14437	Swiss_Albinos_City_of_Hope_Med_Ctr_CA	Retired_Concepts	Swiss Albinos, City of Hope Med Ctr, CA
C14438	Unknown_Dealer	Retired_Concepts	Unknown Dealer
C14439	Non_Inbred_Swiss_Albino	Retired_Concepts	Non Inbred Swiss Albino
C14440	Commercial_Swiss_Albino	Retired_Concepts	Commercial Swiss Albino
C14441	SHN_Mouse	Retired_Concepts	SHN Mouse|SHN
C14442	SLN_Mouse	Retired_Concepts	SLN Mouse|SLN
C14443	SWM_Ms_Mouse	Retired_Concepts	SWM/Ms Mouse|SWM/Ms
C14444	SWJ_Mouse	Retired_Concepts	SWJ Mouse|SWJ
C14445	Pasteur_Inst	Retired_Concepts	Pasteur Inst
C14446	TB_Orl_Mouse	Retired_Concepts	TB/Orl Mouse|TB/Orl
C14447	CJ_Lynch_1926_Rockefeller_Inst	Retired_Concepts	CJ Lynch 1926 Rockefeller Inst
C14448	SJL_J_Mouse	Inbred_Mouse	SJL/J Mouse|SJL/J
C14449	DA_Hu_Mouse	Retired_Concepts	DA/Hu Mouse|DA/Hu
C14450	LT_Webster_1932	Retired_Concepts	LT Webster 1932	An inbred mouse strain developed by JT Webster in 1932.
C14451	TS_Hauschka_Fox_Chase_Ha_ICR	Retired_Concepts	TS Hauschka, Fox Chase Ha:ICR|Icr:Ha(ICR)	This random bred stock was developed at the Institute for Cancer Research (Fox Chase Cancer Center) by Dr. T.S. Hauschka beginning in 1948. Dr. Hauschka developed the high production and high growth rate characteristics of the Icr:Ha(ICR) stock by rigid selection over a period of several years. When he left the Institute for Cancer Research in 1954, Dr. Hauschka took part of his HA(ICR) colony with him to Roswell Park Memorial Institute in Buffalo, N.Y. The remainder of the colony was left at Fox Chase where a modified version of Robertson's mating system has been used to minimize the rate of inbreeding. In agreement with Dr. Hauschka, Fox Chase designates its random bred stock "Icr:Ha(ICR)" to differentiate it from Dr. Hauschka's stock since the two colonies probably began to drift apart genetically very shortly after August, 1959. (from taconic.com)
C14452	Q_S_Mouse	Retired_Concepts	Q(S) Mouse|Q(S)
C14453	IQl_Mouse	Retired_Concepts	IQl Mouse|IQl
C14454	ICW_Mouse	Retired_Concepts	ICW Mouse|ICW
C14455	ICGN_Mouse	Retired_Concepts	ICGN Mouse|ICGN
C14456	ICR	Retired_Concepts	ICR
C14457	ICR_Bc_Mouse	Retired_Concepts	ICR/Bc Mouse|ICR/Bc
C14458	NSY_Mouse	Retired_Concepts	NSY Mouse|NSY
C14459	CTS	Retired_Concepts	CTS
C14460	NON_Mouse	Inbred_Mouse	NON Mouse|NON
C14461	NOD	Retired_Concepts	NOD
C14462	NOR2_Lt_Mouse	Retired_Concepts	NOR2/Lt Mouse|NOR2/Lt
C14463	NOR1_Lt_Mouse	Retired_Concepts	NOR1/Lt Mouse|NOR1/Lt
C14464	IMVS_Mouse	Retired_Concepts	IMVS Mouse|IMVS
C14465	CD-1_ICR_plus_H2440	Retired_Concepts	CD-1 (ICR)|CD-1
C14466	ARC_Mouse	Retired_Concepts	ARC Mouse|ARC
C14467	MS_Ae_Mouse	Retired_Concepts	MS/Ae Mouse|MS/Ae
C14468	SEN_Mouse	Retired_Concepts	SEN Mouse|SEN
C14469	Swiss-Webster	Retired_Concepts	Swiss-Webster
C14470	NMRI	Retired_Concepts	NMRI
C14471	N_NIH_early_40s	Retired_Concepts	N:NIH (early 40s)
C14472	HSFR_N_Mouse	Retired_Concepts	HSFR/N Mouse|HSFR/N
C14473	HSFS_N	Retired_Concepts	HSFS/N
C14474	FVB_N	Inbred_Mouse	FVB/N Mouse|FVB/N
C14475	NU_J_Mouse	Retired_Concepts	NU/J Mouse|NU/J
C14476	NIH_Mouse	Inbred_Mouse	NIH Mouse|NIH
C14477	NGP_Mouse	Retired_Concepts	NGP Mouse|NGP
C14478	NFS_Mouse	Retired_Concepts	NFS Mouse|NFS
C14479	NFR_Mouse	Retired_Concepts	NFR Mouse|NFR
C14480	YPC_Mouse	Retired_Concepts	YPC Mouse|YPC
C14481	IAH_Mouse	Retired_Concepts	IAH Mouse|IAH
C14482	CB_Casas_Puerto_Rico_Unpedigreed_Swiss_1948	Retired_Concepts	CB Casas, Puerto Rico, Unpedigreed Swiss, 1948
C14483	TM_Mouse	Retired_Concepts	TM Mouse|TM
C14484	Swiss	Retired_Concepts	Swiss
C14485	STU_Mouse	Retired_Concepts	STU Mouse|STU
C14486	Kuhrning_Outbred_Swiss_Mice_Haffkin_Med_Sci_Inst	Retired_Concepts	Kuhrning Outbred 'Swiss' Mice, Haffkin Med Sci Inst
C14487	LIBP_I-4_Mouse	Retired_Concepts	LIBP/I-4 Mouse|LIBP/I-4
C14488	ICR_Mice	Retired_Concepts	ICR Mice
C14489	PIC_Mouse	Retired_Concepts	PIC Mouse|PIC
C14490	Non_Inbred_Germ-free_Swiss_Mice_Lobun_Ins_Notre_Dame_1963	Retired_Concepts	Non Inbred, Germ-free Swiss Mice Lobun Ins Notre Dame, 1963
C14491	ND2_RiJ_Mouse	Retired_Concepts	ND2/RiJ Mouse|ND2/RiJ
C14492	Swiss_Albino_Sandoz_Basel_Bxs_1964	Retired_Concepts	Swiss Albino, Sandoz, Basel, Bxs, 1964
C14493	SIM_Mouse	Retired_Concepts	SIM Mouse|SIM
C14494	Dealer_Swiss_Albino_H_Frings_Penn_State_1953	Retired_Concepts	Dealer Swiss Albino, H Frings, Penn State, 1953
C14495	RB_Mouse	Retired_Concepts	RB Mouse|RB
C14496	Swiss_City_of_Hope_Med_Ctr_Duarte_CA	Retired_Concepts	Swiss, City of Hope Med Ctr, Duarte, CA
C14497	HLS_Mouse	Retired_Concepts	HLS Mouse|HLS
C14498	U_California	Retired_Concepts	U. California
C14499	Jcl_ICR-Cts_Nihon_CLEA_1966	Retired_Concepts	Jcl:ICR-Cts, Nihon CLEA, 1966
C14500	CTA_Mouse	Retired_Concepts	CTA Mouse|CTA
C14501	Swiss-Webster_X_C3H_HeAnl-Cas1_SM_Singh_1983	Retired_Concepts	Swiss-Webster X C3H/HeAnl-Cas1 SM Singh 1983
C14502	SXC_Mouse	Retired_Concepts	SXC Mouse|SXC
C14503	Outbred_Swiss_X_A2	Retired_Concepts	Outbred Swiss X A2
C14504	SL_Qdj_Mouse	Retired_Concepts	SL/Qdj Mouse|SL/Qdj
C14505	AKR_J_Mouse	Inbred_Mouse	AKR/J Mouse|AKR/J
C14506	LT_Webster_Rockefeller_Inst_1933	Retired_Concepts	LT Webster, Rockefeller Inst, 1933
C14507	CPB-S_Mouse	Retired_Concepts	CPB-S Mouse|CPB-S
C14508	China_Strain	Retired_Concepts	China Strain
C14509	A_y_Stock	Retired_Concepts	A^y Stock
C14510	YBR_Mouse	Inbred_Mouse	YBR Mouse|YBR
C14511	A_Lathrop_Grandby_1903-1915	Retired_Concepts	A Lathrop, Grandby, 1903-1915
C14512	MA_MyJ_Mouse	Inbred_Mouse	MA/MyJ Mouse|MA/MyJ
C14513	EC_MacDowell_1921_CSH	Retired_Concepts	EC MacDowell, 1921, CSH
C14514	LT_Mouse	Retired_Concepts	LT Mouse|LT
C14515	C58_J_Mouse	Inbred_Mouse	C58/J Mouse|C58/J
C14516	CC_Little_1921	Retired_Concepts	CC Little, 1921
C14517	Brown_Subline	Retired_Concepts	Brown Subline
C14518	BBT_Mouse	Retired_Concepts	BBT Mouse|BBT
C14519	C57L_J_Mouse	Inbred_Mouse	C57L/J Mouse|C57L/J
C14520	C57BR_Jax_Substrains	Retired_Concepts	C57BR Jax Substrains
C14521	MY_Mouse	Retired_Concepts	MY Mouse|MY
C14522	C57_Mouse	Retired_Concepts	C57 Mouse|C57
C14523	Black_Subline_Prior_to_1937	Retired_Concepts	Black Subline Prior to 1937
C14524	FSB_Mouse	Retired_Concepts	FSB Mouse|FSB
C14525	C57BL_10_Jax_Snell_Substrains	Retired_Concepts	C57BL/10 Jax, Snell Substrains|B10
C14526	NBL_Mouse	Retired_Concepts	NBL Mouse|NBL
C14527	C5yBL_10Gn	Retired_Concepts	C5yBL/10Gn
C14528	TF_Mouse	Retired_Concepts	TF Mouse|TF
C14529	SH1_Mouse	Retired_Concepts	SH1 Mouse|SH1
C14530	TP_Mouse	Retired_Concepts	TP Mouse|TP
C14531	AE_Mouse	Retired_Concepts	AE Mouse|AE
C14532	AEJ_Mouse	Retired_Concepts	AEJ Mouse|AEJ
C14533	V_Mouse	Retired_Concepts	V Mouse|V
C14534	EBT_Mouse	Retired_Concepts	EBT Mouse|EBT
C14535	LS_Le_Mouse	Retired_Concepts	LS/Le Mouse|LS/Le
C14536	C57BL_6_Jax_Kaliss_Substrains	Retired_Concepts	C57BL/6 Jax, Kaliss Substrains
C14537	C57_lcr_Mouse	Retired_Concepts	C57/lcr Mouse|C57/lcr
C14538	BT_Os_Mouse	Retired_Concepts	BT/Os Mouse|BT/Os
C14539	H1_Mouse	Retired_Concepts	H1 Mouse|H1
C14540	H2_Mouse	Retired_Concepts	H2 Mouse|H2
C14541	BXSB_Mp_Mouse	Retired_Concepts	BXSB/Mp Mouse|BXSB/Mp
C14542	IDH2_Ei_Mouse	Retired_Concepts	IDH2/Ei Mouse|IDH2/Ei
C14543	AX_Mouse	Retired_Concepts	AX Mouse|AX
C14544	MYD_Mouse	Retired_Concepts	MYD Mouse|MYD
C14545	C57BLKS_Mouse	Inbred_Mouse	C57BLKS Mouse|C57BLKS
C14546	ES_Russell_Jax_1948	Retired_Concepts	ES Russell, Jax, 1948
C14547	WB_Mouse	Retired_Concepts	WB Mouse|WB
C14548	WC_Mouse	Retired_Concepts	WC Mouse|WC
C14549	WH_Mouse	Retired_Concepts	WH Mouse|WH
C14550	WK_Mouse	Retired_Concepts	WK Mouse|WK
C14551	C57BL_6Ha_Mouse	Retired_Concepts	C57BL/6Ha Mouse|C57BL/6Ha
C14552	PH_Re_Mouse	Retired_Concepts	PH/Re Mouse|PH/Re
C14553	RSV_Le_Mouse	Retired_Concepts	RSV/Le Mouse|RSV/Le
C14554	TSJ_Le_Mouse	Retired_Concepts	TSJ/Le Mouse|TSJ/Le
C14555	SHR_Mouse	Retired_Concepts	SHR Mouse|SHR
C14556	SHM_2Gn_Mouse	Retired_Concepts	SHM/2Gn Mouse|SHM/2Gn
C14557	YS_Mouse	Retired_Concepts	YS Mouse|YS
C14558	LC_Strong_1925-1927_12_Pr_Mice_Carrying_Various_Coat-colour_Alleles	Retired_Concepts	LC Strong 1925-1927, 12 Pr Mice Carrying Various Coat-colour Alleles
C14559	I_5t_Mouse	Retired_Concepts	I/5t Mouse|I/5t
C14560	F	Retired_Concepts	F
C14561	FB_Mouse	Retired_Concepts	FB Mouse|FB
C14562	N	Retired_Concepts	N
C14563	NH	Retired_Concepts	NH
C14564	JK	Retired_Concepts	JK
C14565	Tyr_C-ch_Chinchilla_X_Coat_Color_Stocks_English_Fanciers	Retired_Concepts	Tyr C-ch Chinchilla X Coat Color Stocks, English Fanciers
C14566	LP_Mouse	Retired_Concepts	LP Mouse|LP
C14567	_101_Mouse	Inbred_Mouse	101 Mouse|101	Inbr: 66. Genet: A^w. Origin: Dunn, 1936. (Jackson Labs/Festing)
C14568	_102_Mouse	Retired_Concepts	102 Mouse|102	Inbr (El) 93. Agouti: +. Origin: From 101/Rl to El, then presumed genetic contamination. Differs from 101 at the a, Car2, Gpi1^s, Hba and lop2 loci. Maint. by H, El. (Jackson Labs/Festing)
C14569	TJL_Remake_P_p_Tyr_c-ch_Tyr_c_1948	Retired_Concepts	TJL Remake P/p Tyr^c-ch/Tyr^c, 1948
C14570	_1969_Mouse	Retired_Concepts	1969 Mouse|1969
C14571	_129PJ-Lama2_dy_Mouse	Retired_Concepts	129PJ-Lama2^dy Mouse|129PJ-Lama2^dy
C14572	_129P1	Retired_Concepts	129P1
C14573	_129P2_Mouse	Retired_Concepts	129P2 Mouse|129P2
C14574	PRO_Mouse	Retired_Concepts	PRO Mouse|PRO
C14575	_129_Rr	Retired_Concepts	129/Rr
C14576	_129P3_Mouse	Retired_Concepts	129P3 Mouse|129P3
C14577	_129_Sv	Retired_Concepts	129/Sv
C14578	UW_Mouse	Retired_Concepts	UW Mouse|UW	Inbr (Pas) N9 (1994). Under white, uw. Origin: Wild allele of under white found segregating in a Corsican mouse, backcrossed 9 times to 129/Sv. (Jackson Labs/Festing)
C14579	_129X1_SvJ_Mouse	Inbred_Mouse	129X1/SvJ Mouse|129/SvJ|129X1|129X1/SvJ
C14580	_129S1	Retired_Concepts	129S1
C14581	_129S2_Mouse	Retired_Concepts	129S2 Mouse|129S2
C14582	_129S4_Mouse	Retired_Concepts	129S4 Mouse|129S4
C14583	_129S3_Mouse	Retired_Concepts	129S3 Mouse|129S3
C14584	MJ_Evans_1969_129_SvEv	Retired_Concepts	MJ Evans, 1969, 129/SvEv
C14585	_129S5	Retired_Concepts	129S5
C14586	_129S6_Mouse	Retired_Concepts	129S6 Mouse|129S6
C14587	_129_SvEv-Gpi1_c	Retired_Concepts	129/SvEv-Gpi1^c
C14588	_129S7_Mouse	Retired_Concepts	129S7 Mouse|129S7
C14589	_129S8_Mouse	Retired_Concepts	129S8 Mouse|129S8
C14590	_1973_129_Sv-plus_PTyrc-ch_Ter_plus	Retired_Concepts	1973 129/Sv-+PTyrc-ch Ter/+
C14591	_129T1_Mouse	Retired_Concepts	129T1 Mouse|129T1
C14592	_129T2_Mouse	Retired_Concepts	129T2 Mouse|129T2
C14593	Strong_s_Pink-eyed_Stock	Retired_Concepts	Strong's Pink-eyed Stock
C14594	I_LnJ_Mouse	Inbred_Mouse	I/LnJ Mouse|I/LnJ
C14595	BDP_J	Inbred_Mouse	BDP/J Mouse|BDP/J
C14596	SEA_Mouse	Retired_Concepts	SEA Mouse|SEA
C14597	GD_Snell_Jax_1940s	Retired_Concepts	GD Snell, Jax, 1940s
C14598	P_J_Mouse	Inbred_Mouse	P/J Mouse|P/J
C14599	VM	Retired_Concepts	VM
C14600	MB_Mouse	Retired_Concepts	MB Mouse|MB
C14601	IM_Mouse	Retired_Concepts	IM Mouse|IM
C14602	CC_Little_Dbr_1909	Retired_Concepts	CC Little Dbr, 1909
C14603	CC_Little_s_Dba_1929-30	Retired_Concepts	CC Little's Dba, 1929-30
C14604	DBA_2	Inbred_Mouse	DBA/2 Mouse|DBA/2
C14605	MK_ReJ_Mouse	Retired_Concepts	MK/ReJ Mouse|MK/ReJ
C14606	DBA_1	Inbred_Mouse	DBA/1 Mouse|DBA/1
C14607	ATEB_Le_Mouse	Retired_Concepts	ATEB/Le Mouse|ATEB/Le	An inbred mouse strain that arose in a non-inbred hairless stock maintained by Hummel in 1960; maintained by Le.
C14608	JW_MacArthur_7-way_Cross_1939	Retired_Concepts	JW MacArthur 7-way Cross 1939
C14609	Large_Line	Retired_Concepts	Large Line
C14610	JU_Mouse	Retired_Concepts	JU Mouse|JU
C14611	Small_Line	Retired_Concepts	Small Line
C14612	SM_J_Mouse	Inbred_Mouse	SM/J Mouse|SM/J
C14613	SM_JH_Mouse	Retired_Concepts	SM/JH Mouse|SM/JH
C14614	Strong	Retired_Concepts	Strong
C14615	Stock_C	Retired_Concepts	Stock C
C14616	C121_Mouse	Retired_Concepts	C121 Mouse|C121
C14617	C_5t_Mouse	Retired_Concepts	C/5t Mouse|C/5t
C14618	Stock_CH	Retired_Concepts	Stock CH
C14619	CHI_Mouse	Retired_Concepts	CHI Mouse|CHI
C14620	CKB_Mouse	Retired_Concepts	CKB Mouse|CKB
C14621	C3H	Retired_Concepts	C3H
C14622	C3HA_Mouse	Retired_Concepts	C3HA Mouse|C3HA
C14623	BLRB_Mouse	Retired_Concepts	BLRB Mouse|BLRB
C14624	CBRB_Mouse	Retired_Concepts	CBRB Mouse|CBRB
C14625	Stock_CB	Retired_Concepts	Stock CB
C14626	CBA	Retired_Concepts	CBA
C14627	BRS	Retired_Concepts	BRS
C14628	BRSUNT_Mouse	Retired_Concepts	BRSUNT Mouse|BRSUNT
C14629	CBA_Jax_Andervont_Substrains	Retired_Concepts	CBA Jax, Andervont Substrains
C14630	ME_Wallace_Cam_1979	Retired_Concepts	ME Wallace, Cam, 1979
C14631	PUH_Mouse	Retired_Concepts	PUH Mouse|PUH
C14632	PUC_Mouse	Retired_Concepts	PUC Mouse|PUC
C14633	CBA_Ca-se_Ld_limb_Deformity_Mutn_MC_Green_Jax_1959	Retired_Concepts	CBA/Ca-se Ld (limb Deformity) Mutn, MC Green, Jax, 1959
C14634	LDJ_Le_Mouse	Retired_Concepts	LDJ/Le Mouse|LDJ/Le
C14635	Chester_Beatty_Inst_1962	Retired_Concepts	Chester Beatty Inst, 1962
C14636	CWD_Le_Mouse	Retired_Concepts	CWD/Le Mouse|CWD/Le
C14637	IC_Le_Mouse	Retired_Concepts	IC/Le Mouse|IC/Le
C14638	CBA_CaLac	Retired_Concepts	CBA/CaLac
C14639	AU_SsJ_Mouse	Inbred_Mouse	AU/SsJ Mouse|AU/SsJ
C14640	Haldane_Gruneberg_1932	Retired_Concepts	Haldane, Gruneberg, 1932
C14641	CBA_Bonser_Carter_Substrains_Mouse	Retired_Concepts	CBA Bonser, Carter Substrains Mouse|CBA Bonser, Carter Substrains
C14642	AG_Cam_Mouse	Retired_Concepts	AG/Cam Mouse|AG/Cam
C14643	Stock_A	Retired_Concepts	Stock A
C14644	JJ_Bittner_1927	Retired_Concepts	JJ Bittner 1927
C14645	STAR_Mouse	Retired_Concepts	STAR Mouse|STAR
C14646	AL_Mouse	Retired_Concepts	AL Mouse|AL
C14647	A2G_Mouse	Inbred_Mouse	A2G Mouse|A2G
C14648	A_Br_Mouse	Retired_Concepts	A/Br Mouse|A/Br
C14649	A_Fa_Mouse	Retired_Concepts	A/Fa Mouse|A/Fa
C14650	A_J	Inbred_Mouse	A/J Mouse|A/J
C14651	CL_Fr_Mouse	Retired_Concepts	CL/Fr Mouse|CL/Fr
C14652	A_He_Mouse	Inbred_Mouse	A/He Mouse|A/He
C14653	A	Retired_Concepts	A
C14654	LPT_Le_Mouse	Retired_Concepts	LPT/Le Mouse|LPT/Le
C14655	CC_Little	Retired_Concepts	CC Little
C14656	BL_Mouse	Retired_Concepts	BL Mouse|BL
C14657	BALB_cJ	Inbred_Mouse	BALB/cJ Mouse|BALB/cJ
C14658	SEC_1ReJ_Mouse	Retired_Concepts	SEC/1ReJ Mouse|SEC/1ReJ
C14659	RHJ_LeJ_Mouse	Retired_Concepts	RHJ/LeJ Mouse|RHJ/LeJ
C14660	DC_Le_Mouse	Retired_Concepts	DC/Le Mouse|DC/Le
C14661	ABJ_Le_Mouse	Retired_Concepts	ABJ/Le Mouse|ABJ/Le
C14662	CC57_Substrains_Mouse	Retired_Concepts	CC57 Substrains Mouse|CC57 Substrains
C14663	L1_Mouse	Retired_Concepts	L1 Mouse|L1
C14664	DH_Mouse	Retired_Concepts	DH Mouse|DH
C14665	C_B17_Mouse	Retired_Concepts	C.B17 Mouse|C.B17
C14666	J_Furth_1928-36_Rockefeller_Inst	Retired_Concepts	J Furth 1928-36, Rockefeller Inst
C14667	AKR_FuA	Retired_Concepts	AKR/FuA
C14668	ACR_A_Mouse	Retired_Concepts	ACR/A Mouse|ACR/A
C14669	AKR_J	Retired_Concepts	AKR/J (?)
C14670	T_Takeda_Kyoto_1970	Retired_Concepts	T Takeda, Kyoto 1970
C14671	SAMR4_Mouse	Retired_Concepts	SAMR4 Mouse|SAMR4
C14672	SAMR1_Mouse	Retired_Concepts	SAMR1 Mouse|SAMR1
C14673	SAMP1_Mouse	Retired_Concepts	SAMP1 Mouse|SAMP1
C14674	SAMP2_Mouse	Retired_Concepts	SAMP2 Mouse|SAMP2
C14675	SAMP3_Mouse	Retired_Concepts	SAMP3 Mouse|SAMP3
C14676	SAMP6_Mouse	Retired_Concepts	SAMP6 Mouse|SAMP6
C14677	SAMP7_Mouse	Retired_Concepts	SAMP7 Mouse|SAMP7
C14678	SAMP8_Mouse	Retired_Concepts	SAMP8 Mouse|SAMP8
C14679	SAMP9_Mouse	Retired_Concepts	SAMP9 Mouse|SAMP9
C14680	SAMP10_Mouse	Retired_Concepts	SAMP10 Mouse|SAMP10
C14681	SAMP11_Mouse	Retired_Concepts	SAMP11 Mouse|SAMP11
C14682	RFM_Mouse	Retired_Concepts	RFM Mouse|RFM
C14683	RF_J	Inbred_Mouse	RF/J Mouse|RF/J
C14684	NZB_BINJ_X_RF_J_R_and_C_Wimer_1981	Retired_Concepts	NZB/BINJ X RF/J R and C Wimer, 1981
C14685	SZA_Mouse	Retired_Concepts	SZA Mouse|SZA
C14686	SZB_Mouse	Retired_Concepts	SZB Mouse|SZB
C14687	SZC_Mouse	Retired_Concepts	SZC Mouse|SZC
C14688	Rockefeller_Inst_Heterogeneous_Stock_R_Strain	Retired_Concepts	Rockefeller Inst, Heterogeneous Stock, R Strain
C14689	SC_Mouse	Retired_Concepts	SC Mouse|SC
C14690	BSVS	Retired_Concepts	BSVS
C14691	BSC_Mouse	Retired_Concepts	BSC Mouse|BSC
C14692	BSCR	Retired_Concepts	BSCR
C14693	BRVS	Retired_Concepts	BRVS
C14694	BRVR_Mouse	Retired_Concepts	BRVR Mouse|BRVR
C14695	European_and_US_Stocks	Retired_Concepts	European and US Stocks
C14696	NZW	Retired_Concepts	NZW
C14697	NZM_Mouse	Retired_Concepts	NZM Mouse|NZM
C14698	NZY	Retired_Concepts	NZY
C14699	NZC	Retired_Concepts	NZC
C14700	NZX_Mouse	Retired_Concepts	NZX Mouse|NZX
C14701	NZO	Retired_Concepts	NZO
C14702	NZBR_Mouse	Retired_Concepts	NZBR Mouse|NZBR
C14703	OUBCr_Mouse	Retired_Concepts	OUBCr Mouse|OUBCr
C14704	NZB	Retired_Concepts	NZB
C14705	A_Kirschbaum_Baylor_1942-52	Retired_Concepts	A Kirschbaum, Baylor, 1942-52
C14706	L2_Mouse	Retired_Concepts	L2 Mouse|L2
C14707	Multiple_Crosses_C57L_DBA_2_C57BL-go_129_J	Retired_Concepts	Multiple Crosses: C57L, DBA/2, C57BL-go, 129/J
C14708	YT_Y_Mouse	Retired_Concepts	YT/Y Mouse|YT/Y
C14709	C57BL_6J_C57BR_cdJ_A_J_BALB_cJ_LG_Ckc_SM_Ckc	Retired_Concepts	C57BL/6J, C57BR/cdJ, A/J, BALB/cJ, LG/Ckc, SM/Ckc
C14710	LLC_Ckc_Mouse	Retired_Concepts	LLC/Ckc Mouse|LLC/Ckc
C14711	HLC_Ckc_Mouse	Retired_Concepts	HLC/Ckc Mouse|HLC/Ckc
C14712	Heterogeneous_Stock_from_A_Sn_BALB_c_CBA_Ca_C57BL_6J_DBA_2_GLF_I_St_101_H	Retired_Concepts	Heterogeneous Stock from A/Sn, BALB/c, CBA/Ca, C57BL/6J, DBA/2, GLF, I/St, 101/H
C14713	TPS_Y_Mouse	Retired_Concepts	TPS/Y Mouse|TPS/Y
C14714	Heterogeneous_Background	Retired_Concepts	Heterogeneous Background
C14715	MWT_Le_Mouse	Retired_Concepts	MWT/Le Mouse|MWT/Le
C14716	Crossbred_between_Japanese_and_US_Stocks	Retired_Concepts	Crossbred between Japanese and US Stocks
C14717	IXBL_Mouse	Retired_Concepts	IXBL Mouse|IXBL
C14718	Ra_ragged_Os_oligosyndactylism_and_Pt_pintail_Stock_MC_Green_Jax_1960	Retired_Concepts	Ra (ragged), Os (oligosyndactylism) and Pt (pintail) Stock, MC Green, Jax, 1960
C14719	ROP_Le_Mouse	Retired_Concepts	ROP/Le Mouse|ROP/Le
C14720	M_Davisson_1984	Retired_Concepts	M Davisson, 1984
C14721	RBJ_Mouse	Retired_Concepts	RBJ Mouse|RBJ
C14722	Other_Inbred_Strains	Retired_Concepts	Other Inbred Strains
C14723	Strain_Developed_from_Intercrosses_of_8_Inbred_Strains_A_AK_BALB_c_C3H_C57BL_DBA_2_IS_Bi_and_RIII	Retired_Concepts	Strain Developed from Intercrosses of 8 Inbred Strains A, AK, BALB/c, C3H, C57BL, DBA/2, IS/Bi, and RIII
C14724	LS_lbg_Mouse	Retired_Concepts	LS/lbg Mouse|LS/lbg
C14725	H2_Recombinant_from_c57BL_X_A_F1	Retired_Concepts	H2 Recombinant from (c57BL X A)F1
C14726	HTI_Mouse	Retired_Concepts	HTI Mouse|HTI
C14727	H2_Recombinant_from_Heterogeneous_Stock	Retired_Concepts	H2 Recombinant from Heterogeneous Stock
C14728	HTH_Mouse	Retired_Concepts	HTH Mouse|HTH
C14729	H2_Recombinant_from_c57BL_X_BALB_c_F1	Retired_Concepts	H2 Recombinant from (c57BL X BALB/c)F1
C14730	HTG_GoSfSn_Mouse	Retired_Concepts	HTG/GoSfSn Mouse|HTG/GoSfSn
C14731	_8_Way_Cross_1966_G_Schlager_Kansas_U	Retired_Concepts	8 Way Cross, 1966, G Schlager, Kansas U
C14732	BPH_2Slg_Mouse	Retired_Concepts	BPH/2Slg Mouse|BPH/2Slg
C14733	BPL_1_Mouse	Retired_Concepts	BPL/1 Mouse|BPL/1
C14734	BPN_3_Mouse	Retired_Concepts	BPN/3 Mouse|BPN/3
C14735	JC_DeFries_Colorado_U_Heterogeneous_Stock	Retired_Concepts	JC DeFries, Colorado U, Heterogeneous Stock
C14736	LS_Mouse	Retired_Concepts	LS Mouse|LS
C14737	ISS_Mouse	Retired_Concepts	ISS Mouse|ISS
C14738	Female_Heterogeneous_Stock_Hy2_hydrocephalus-3_Mutn_H_Gruneberg_UCL_1941	Retired_Concepts	Female Heterogeneous Stock Hy2 (hydrocephalus-3) Mutn, H Gruneberg, UCL, 1941
C14739	HYlII_Le	Retired_Concepts	HYlII/Le
C14740	GT_Le_Mouse	Retired_Concepts	GT/Le Mouse|GT/Le
C14741	Hpt_hair_Patches_Mutn	Retired_Concepts	Hpt (hair Patches) Mutn
C14742	HPT_Le_Mouse	Retired_Concepts	HPT/Le Mouse|HPT/Le
C14743	NBC_and_SII_Hybrids_K_Kondo_Nagoya_U_1956	Retired_Concepts	NBC and SII Hybrids, K Kondo, Nagoya U, 1956
C14744	CS_Nga	Retired_Concepts	CS/Nga
C14745	IITES_Mouse	Retired_Concepts	IITES Mouse|IITES
C14746	Nishiki-nezumi_Japanese_Fancy_Mice_K_Kondo_Nagoya_1944-49	Retired_Concepts	Nishiki-nezumi Japanese Fancy Mice K Kondo, Nagoya, 1944-49
C14747	NBC	Retired_Concepts	NBC
C14748	Hybrids_Between_KSB_and_NBR_K_Kondo_Nagoya_U_1954	Retired_Concepts	Hybrids Between KSB and NBR, K Kondo, Nagoya U, 1954|Hybrids Betwee KSB and NBR, K Kondo, Nagoya U, 1954
C14749	SII	Retired_Concepts	SII
C14750	ITES	Retired_Concepts	ITES
C14751	Ed_Murphy_Jax_1960_3_C57BL_6J_and_12_1_C3H_HeDi_and_75_0_LG_J_and_12_6_AKR_J	Retired_Concepts	Ed Murphy, Jax 1960 (.3% C57BL/6J and 12.1% C3H/HeDi and 75.0% LG/J and 12.6% AKR/J)
C14752	MRLS_MpJ_Mouse	Retired_Concepts	MRLS/MpJ Mouse|MRLS/MpJ
C14753	BALB_cGa_129_CBA_and_ICR_TM_Gunn_DM_Juriloff_UBC_1991	Retired_Concepts	BALB/cGa, 129, CBA and ICR, TM Gunn, DM Juriloff, UBC, 1991
C14754	SELH_Mouse	Retired_Concepts	SELH Mouse|SELH
C14755	MT_Davisson_Jax_Female_NMRI_X_Wild_Make	Retired_Concepts	MT Davisson, Jax Female NMRI X Wild Make
C14756	RBG_Dn_Mouse	Retired_Concepts	RBG/Dn Mouse|RBG/Dn
C14757	Unknown_Origin	Retired_Concepts	Unknown Origin
C14758	Kitasato	Retired_Concepts	Kitasato
C14759	DHS_Mouse	Retired_Concepts	DHS Mouse|DHS
C14760	Japan_Old_N_Stock	Retired_Concepts	Japan Old N Stock
C14761	DSD_Mouse	Retired_Concepts	DSD Mouse|DSD
C14762	Nobunaga_Chugal_1960	Retired_Concepts	Nobunaga/Chugal, 1960
C14763	IVCE_Mouse	Retired_Concepts	IVCE Mouse|IVCE
C14764	IVCS_Mouse	Retired_Concepts	IVCS Mouse|IVCS
C14765	DDI_Mouse	Retired_Concepts	DDI Mouse|DDI
C14766	DDK_Mouse	Inbred_Mouse	DDK Mouse|DDK
C14767	DD	Retired_Concepts	DD
C14768	DTB_Mouse	Retired_Concepts	DTB Mouse|DTB
C14769	Inbred_Dd_Mice	Retired_Concepts	Inbred Dd Mice
C14770	D103_MS_Mouse	Retired_Concepts	D103/MS Mouse|D103/MS
C14771	DM_Mouse	Retired_Concepts	DM Mouse|DM
C14772	DDD	Retired_Concepts	DDD
C14773	BALB_c-Hfh11nu_X_DD_1	CBy_Cg-Foxn1-nu	BALB/c-Hfh11nu X DD/1
C14774	KSN_Mouse	BALB_c-Hfh11nu_X_DD_1	KSN Mouse|KSN
C14775	N8	Retired_Concepts	N8
C14776	DRC_Mouse	Retired_Concepts	DRC Mouse|DRC
C14777	DDY_Mouse	Inbred_Mouse	DDY Mouse|DDY
C14778	DKI	Retired_Concepts	DKI
C14779	DKI-R_Mouse	Retired_Concepts	DKI-R Mouse|DKI-R
C14780	KF_Mouse	Retired_Concepts	KF Mouse|KF
C14781	FRG_Mouse	Retired_Concepts	FRG Mouse|FRG
C14782	Japanese_Fancy_Mice	Retired_Concepts	Japanese Fancy Mice
C14783	NC_Mouse	Retired_Concepts	NC Mouse|NC
C14784	Various_Hybrids_1944-49	Retired_Concepts	Various Hybrids, 1944-49
C14785	NBR_Mouse	Retired_Concepts	NBR Mouse|NBR
C14786	Tianjin_China	Retired_Concepts	Tianjin, China
C14787	_615_Mouse	Retired_Concepts	615 Mouse|615
C14788	Kimaizumi_NIH_Tokyo_1954	Retired_Concepts	Kimaizumi, NIH, Tokyo, 1954
C14789	Epilepsy_Mut_Non_Inbred_Albino	Retired_Concepts	Epilepsy Mut, Non Inbred Albino
C14790	EL_Mouse	Retired_Concepts	EL Mouse|EL
C14791	Kunming_Stock_Peking_Bioproducts_1972	Retired_Concepts	Kunming Stock, Peking Bioproducts, 1972
C14792	AMMS_1_Mouse	Retired_Concepts	AMMS/1 Mouse|AMMS/1
C14793	Peking_Bioproducts_Inst_1962_Outbred_Kunming	Retired_Concepts	Peking Bioproducts, Inst, 1962, Outbred Kunming
C14794	TA2_Mouse	Retired_Concepts	TA2 Mouse|TA2
C14795	Tianjin_China_1956_Outbred	Retired_Concepts	Tianjin, China, 1956, Outbred
C14796	TA1_Mouse	Retired_Concepts	TA1 Mouse|TA1
C14797	US_Army_Gen_Med_Lab	Retired_Concepts	US Army Gen Med Lab
C14798	S_Nishida_Tohoku_U	Retired_Concepts	S Nishida, Tohoku U
C14799	SS_Mouse	Retired_Concepts	SS Mouse|SS
C14800	Japanese_Fancy_Mice_2	Retired_Concepts	Japanese Fancy Mice (2)
C14801	Bxs_1958	Retired_Concepts	Bxs 1958
C14802	FM_Mouse	Retired_Concepts	FM Mouse|FM
C14803	US_Army_Gen_Med_Lab_2	Retired_Concepts	US Army Gen Med Lab (2)
C14804	K_Konda_Nagoya_U_1944	Retired_Concepts	K Konda, Nagoya U, 1944
C14805	KSB_Mouse	Retired_Concepts	KSB Mouse|KSB
C14806	KK_Mouse	Retired_Concepts	KK Mouse|KK
C14807	KR_Mouse	Retired_Concepts	KR Mouse|KR
C14808	S_Nishida_Tohoku_U_1951	Retired_Concepts	S Nishida, Tohoku U, 1951
C14809	AA_Mouse	Retired_Concepts	AA Mouse|AA
C14810	Japanese_Fancy_Mice_Sendai	Retired_Concepts	Japanese Fancy Mice, Sendai
C14811	T_Ino_1963	Retired_Concepts	T Ino, 1963
C14812	RR_Mouse	Retired_Concepts	RR Mouse|RR
C14813	Four_Pairs_KM_Outbred	Retired_Concepts	Four Pairs KM Outbred
C14814	NJS_Mouse	Retired_Concepts	NJS Mouse|NJS
C14815	Developed_from_Crosses_of_CBA_A_HeNga_Dd_and_NC_Nga	Retired_Concepts	Developed from Crosses of CBA, A/HeNga, Dd, and NC/Nga
C14816	KYF_Ms_Mouse	Retired_Concepts	KYF/Ms Mouse|KYF/Ms
C14817	KYF_Hok_Mouse	Retired_Concepts	KYF/Hok Mouse|KYF/Hok
C14818	Female_Kunming_Albino_X_Male_615	Retired_Concepts	Female Kunming Albino X Male 615
C14819	T739_Mouse	Retired_Concepts	T739 Mouse|T739
C14820	Outbred_Jcl_dd	Retired_Concepts	Outbred Jcl:dd
C14821	DDN_Mouse	Retired_Concepts	DDN Mouse|DDN
C14822	DDP_Mouse	Retired_Concepts	DDP Mouse|DDP
C14823	European_Origin	Retired_Concepts	European Origin
C14824	Wild_Mice_Trapped_in_Toulouse_France_1976_J-L_Guenet_M_M_Domesticus	Retired_Concepts	Wild Mice Trapped in Toulouse, France 1976, J-L Guenet, M M Domesticus
C14825	WLA_Pas_Mouse	Retired_Concepts	WLA/Pas Mouse|WLA/Pas
C14826	Wild_Mice_Trapped_Sanga_Fe_Nr_Granada_Spain_L_Thaler_1978_M_Spretus	Retired_Concepts	Wild Mice Trapped Sanga Fe, Nr Granada, Spain, L Thaler 1978, M Spretus
C14827	SEG_Pas_Mouse	Retired_Concepts	SEG/Pas Mouse|SEG/Pas
C14828	Wild_Mice_Trapped_Illmitz_Austria_F_Bonhomme_U_Montpellier_1981_M_M_Musculus	Retired_Concepts	Wild Mice Trapped Illmitz, Austria F Bonhomme, U Montpellier, 1981, M M Musculus
C14829	MAI_Pas_Mouse	Retired_Concepts	MAI/Pas Mouse|MAI/Pas
C14830	Wild_Mice_Trapped_Val_Bregaglia_Grisons_SE_Switzerland_M_M_Domesticus	Retired_Concepts	Wild Mice Trapped Val Bregaglia, Grisons, SE Switzerland, M M Domesticus
C14831	RBB_Dn_Mouse	Retired_Concepts	RBB/Dn Mouse|RBB/Dn
C14832	Wild_Mice_Trapped_Aluba_Valley_Grisons_SE_Switzerland_M_M_Domesticus	Retired_Concepts	Wild Mice Trapped Aluba Valley, Grisons, SE Switzerland, M M Domesticus
C14833	RBA_Dn_Mouse	Retired_Concepts	RBA/Dn Mouse|RBA/Dn
C14834	Trapped_by_D_Katarnovsli_in_Serbia_1979_for_RD_Sage_UC_Berkeley_M_Hortulanus	Retired_Concepts	Trapped by D Katarnovsli in Serbia 1979 for RD Sage, UC Berkeley, M Hortulanus
C14835	PANCEVO_Ei_Mouse	Retired_Concepts	PANCEVO/Ei Mouse|PANCEVO/Ei
C14836	_3_Mice_Trapped_Stockholm_Island_off_Pembrokeshire_RJ_Berry_1962_M_M_Domesticus	Retired_Concepts	3 Mice Trapped Stockholm, Island off Pembrokeshire, RJ Berry, 1962, M M Domesticus
C14837	SK_CamEi_Mouse	Retired_Concepts	SK/CamEi Mouse|SK/CamEi
C14838	Wild_Mice_Trapped_in_Lhotka_Nr_Prague_J_Forejt_1974_M_M_Musculus	Retired_Concepts	Wild Mice Trapped in Lhotka Nr Prague, J Forejt, 1974, M M Musculus
C14839	PWD_Ph_Mouse	Retired_Concepts	PWD/Ph Mouse|PWD/Ph
C14840	PWB_Mouse	Retired_Concepts	PWB Mouse|PWB
C14841	Wild_Mice_Trapped_in_Photka_Nr_Prague_J_Forejt_1974_M_M_Musculus	Retired_Concepts	Wild Mice Trapped in Photka Nr Prague, J Forejt, 1974, M M Musculus
C14842	V_Chapman_Roswell_Park	Retired_Concepts	V Chapman, Roswell Park
C14843	PWK_Ph_Mouse	Retired_Concepts	PWK/Ph Mouse|PWK/Ph
C14844	Switzerland_X_Han_NMRI_M_M_Poschiavinus	Retired_Concepts	Switzerland X Han: NMRI, M M Poschiavinus
C14845	RBF_Dn_Mouse	Retired_Concepts	RBF/Dn Mouse|RBF/Dn
C14846	RBD_Dn_Mouse	Retired_Concepts	RBD/Dn Mouse|RBD/Dn
C14847	Trapped_Saldeckovce_Czech_for_RD_Sage_UC_Berkeley_1978_M_M_Musculus	Retired_Concepts	Trapped Saldeckovce, Czech, for RD Sage UC Berkeley, 1978, M M Musculus
C14848	CZECHII_Ei_Mouse	Retired_Concepts	CZECHII/Ei Mouse|CZECHII/Ei
C14849	Wild_Mice_Trapped_in_Puerto_Real_Spain_RD_Sage_UC_Berkeley_1978_M_Spretus	Retired_Concepts	Wild Mice Trapped in Puerto Real, Spain, RD Sage, UC Berkeley, 1978, M Spretus
C14850	SPRET_Ei_Mouse	Retired_Concepts	SPRET/Ei Mouse|SPRET/Ei
C14851	Wild_Mice_Trapped_General_Toshevo_Bulgaria_1980_F_Bonhomme_Montpellier_U_M_M_Musculus	Retired_Concepts	Wild Mice Trapped General Toshevo, Bulgaria, 1980 F Bonhomme, Montpellier U, M M Musculus
C14852	MBT_Pas_Mouse	Retired_Concepts	MBT/Pas Mouse|MBT/Pas
C14853	Wild_Mice_Trapped_at_Montpellier_U_F_Bonhomme_1970s_M_M_Domesticus	Retired_Concepts	Wild Mice Trapped at Montpellier U, F Bonhomme, 1970s, M M Domesticus
C14854	BFM_2_Mouse	Retired_Concepts	BFM/2 Mouse|BFM/2
C14855	Trapped_Santa_Fe_nr_Granada_Spain_by_Louis_Thaler_1978_M_Spretus	Retired_Concepts	Trapped Santa Fe (nr Granada), Spain by Louis Thaler, 1978, M Spretus
C14856	SPE_Mouse	Retired_Concepts	SPE Mouse|SPE
C14857	Trapped_in_Zalende_Switzerland_RD_Sage_UC_Berkeley_M_M_Domesticus	Retired_Concepts	Trapped in Zalende, Switzerland, RD Sage, UC Berkeley, M M Domesticus
C14858	ALENDE_Ei_Mouse	Retired_Concepts	ALENDE/Ei Mouse|ALENDE/Ei
C14859	Wild_Mice_Trapped_in_Israeli_Port_D_Michie_M_M_Praetextus	Retired_Concepts	Wild Mice Trapped in Israeli Port, D Michie, M M Praetextus
C14860	IS_cam_Mouse	Retired_Concepts	IS/cam Mouse|IS/cam
C14861	African_Origin	Retired_Concepts	African Origin
C14862	Wild_Mice_Monastir_Tunisia_G_Lefranc_1980_M_M_Domesticus	Retired_Concepts	Wild Mice, Monastir, Tunisia, G Lefranc, 1980, M M Domesticus
C14863	WMP_Pas_Mouse	Retired_Concepts	WMP/Pas Mouse|WMP/Pas
C14864	Asian_Origin	Retired_Concepts	Asian Origin
C14865	Wild_Mice_Trapped_in_Thailand_JT_Marshall_M_M_Castaneus	Retired_Concepts	Wild Mice Trapped in Thailand, JT Marshall, M M Castaneus
C14866	CASA_Rk_Mouse	Retired_Concepts	CASA/Rk Mouse|CASA/Rk
C14867	CAST_Ei_Mouse	Inbred_Mouse	CAST/Ei Mouse|CAST/Ei
C14868	Albino_Mice_Tokyo_U_M_M_Musculus	Retired_Concepts	Albino Mice, Tokyo U, M M Musculus
C14869	MT_Hokldr	Retired_Concepts	MT/Hokldr
C14870	MTH_Mouse	Retired_Concepts	MTH Mouse|MTH
C14871	Japanese_Tree_Mice_M_Potter_NIH_1969_M_M_Molossinus	Retired_Concepts	Japanese Tree Mice, M Potter, NIH 1969, M M Molossinus
C14872	MOLF_Ei_Mouse	Retired_Concepts	MOLF/Ei Mouse|MOLF/Ei
C14873	MOLC_Rk	Retired_Concepts	MOLC/Rk
C14874	MOLG_Dn_Mouse	Retired_Concepts	MOLG/Dn Mouse|MOLG/Dn
C14875	MOLD_RK	Retired_Concepts	MOLD/RK
C14876	MOLE_Mouse	Retired_Concepts	MOLE Mouse|MOLE
C14877	Wild_Mice_Trapped_Mishima_City_Shizuoka_Prefecture_Japan_M_M_Molossinus	Retired_Concepts	Wild Mice Trapped Mishima City, Shizuoka Prefecture, Japan, M M Molossinus
C14878	MSM_Mouse	Retired_Concepts	MSM Mouse|MSM
C14879	Wild_Mice_Trapped_in_Anjo-City_Japan_M_M_Molossinus	Retired_Concepts	Wild Mice Trapped in Anjo-City, Japan, M M Molossinus
C14880	MOA_Mouse	Retired_Concepts	MOA Mouse|MOA
C14881	Wild_Mice_Trapped_Mizuho_District_Nagoya_City_Japan_M_M_Molossinus	Retired_Concepts	Wild Mice Trapped Mizuho District, Nagoya City, Japan, M M Molossinus
C14882	MOM_Mouse	Retired_Concepts	MOM Mouse|MOM
C14883	Wild_Mice_Trapped_Nishiocity_Japan_1980_M_M_Molossinus	Retired_Concepts	Wild Mice Trapped Nishiocity, Japan, 1980, M M Molossinus
C14884	MOL-NIS_Mouse	Retired_Concepts	MOL-NIS Mouse|MOL-NIS
C14885	Japanese_Fancy_Mice_M_M_Molossinus	Retired_Concepts	Japanese Fancy Mice, M M Molossinus
C14886	JF1_Mouse	Retired_Concepts	JF1 Mouse|JF1
C14887	American_Origin	Retired_Concepts	American Origin
C14888	Wild_Mice_Trapped_Centerville_MD_M_M_Domesticus	Retired_Concepts	Wild Mice Trapped Centerville, MD, M M Domesticus
C14889	CLA2_Cn_Mouse	Retired_Concepts	CLA2/Cn Mouse|CLA2/Cn
C14890	CLA_Mouse	Retired_Concepts	CLA Mouse|CLA
C14891	WSA_Mouse	Retired_Concepts	WSA Mouse|WSA
C14892	WSB_Mouse	Retired_Concepts	WSB Mouse|WSB
C14893	Wild_Pair_Trapped_in_Philadelphia_Factory_H_Winston_U_Penn_1970s_M_M_Musculus	Retired_Concepts	Wild Pair Trapped in Philadelphia Factory, H Winston, U. Penn, 1970s, M M Musculus
C14894	PAA_Mouse	Retired_Concepts	PAA Mouse|PAA
C14895	PAB_Mouse	Retired_Concepts	PAB Mouse|PAB
C14896	PAC_Mouse	Retired_Concepts	PAC Mouse|PAC
C14897	PAD_Mouse	Retired_Concepts	PAD Mouse|PAD
C14898	Wild_Mice_Trapped_Pigeon_Ontario_ML_Petras_M_M_Molossinus	Retired_Concepts	Wild Mice Trapped Pigeon, Ontario, ML Petras, M M Molossinus
C14899	DOPG_Mouse	Retired_Concepts	DOPG Mouse|DOPG
C14900	Wild_Mice_Trapped_in_Rimac_Valley_Peru_J_Coppock_M_M_Domesticus	Retired_Concepts	Wild Mice Trapped in Rimac Valley Peru, J Coppock, M M Domesticus
C14901	PERC_Ei_Mouse	Retired_Concepts	PERC/Ei Mouse|PERC/Ei
C14902	Wild_Mice_Trapped_in_Ohio_J_Bruell_Case_Western_U_Early_1960s_M_M_Domesticus	Retired_Concepts	Wild Mice Trapped in Ohio, J Bruell, Case Western U, Early 1960s, M M Domesticus
C14903	MOR2_Mouse	Retired_Concepts	MOR2 Mouse|MOR2
C14904	MOR_Mouse	Retired_Concepts	MOR Mouse|MOR
C14905	Wild_Mice_Trapped_in_Rimac_Valley_Peru_J_Coppock_M_M_Domesticus_2_plus_H2732	Retired_Concepts	Wild Mice Trapped in Rimac Valley Peru, J Coppock, M M Domesticus (2)
C14906	PERU-COPPOCK_W4_Mouse	Retired_Concepts	PERU-COPPOCK W4 Mouse|PERU-COPPOCK W4
C14907	_7_Breeders_Trapped_by_Olga_Attack_Peru_1961_M_M_Domesticus	Retired_Concepts	7 Breeders Trapped by Olga Attack Peru, 1961, M M Domesticus
C14908	PERA_Mouse	Retired_Concepts	PERA Mouse|PERA
C14909	Wild_Mice_Trapped_in_Coal_Mine_by_RL_Rudd_UC_Davis_1951_M_M_Domesticus	Retired_Concepts	Wild Mice Trapped in Coal Mine by RL Rudd, UC Davis, 1951, M M Domesticus
C14910	SF_Mouse	Retired_Concepts	SF Mouse|SF
C14911	C57BL_Gr-Myo5ad_d-l_dilute_Lethal_Mutn_GM_Truslove_UCL_1950	Retired_Concepts	C57BL/Gr-Myo5ad^d-l (dilute Lethal) Mutn GM Truslove, UCL, 1950
C14912	DLS_Le_Mouse	Retired_Concepts	DLS/Le Mouse|DLS/Le
C14913	ML_Lamoreuz_Harwell_TOE_By_RW_JUN_Stock	Retired_Concepts	ML Lamoreuz, Harwell TOE, By, RW, JUN Stock
C14914	DK_Lm_Mouse	Retired_Concepts	DK/Lm Mouse|DK/Lm
C14915	Balanced_Se_plus_plus_short_Ear_Dl_dilute_Lethal_GM_Truslove	Retired_Concepts	Balanced Se+/+ (short Ear) Dl (dilute Lethal), GM Truslove
C14916	DL_Mouse	Retired_Concepts	DL Mouse|DL
C14917	Varicoloured_Outbreds_Carring_Dw_dwarf_California	Retired_Concepts	Varicoloured Outbreds Carring Dw (dwarf), California
C14918	OUCW_Mouse	Retired_Concepts	OUCW Mouse|OUCW
C14919	OUBW_Mouse	Retired_Concepts	OUBW Mouse|OUBW
C14920	OUGW_Mouse	Retired_Concepts	OUGW Mouse|OUGW
C14921	Anna_Dex_Gliwice_1950	Retired_Concepts	Anna Dex, Gliwice, 1950
C14922	BN_a_Mouse	Retired_Concepts	BN/a Mouse|BN/a
C14923	BN_b_Mouse	Retired_Concepts	BN/b Mouse|BN/b
C14924	P_Schafer_Tubingen_1958	Retired_Concepts	P Schafer, Tubingen, 1958
C14925	TSI_Mouse	Retired_Concepts	TSI Mouse|TSI
C14926	RC_Roberts_Edinburgh_1968	Retired_Concepts	RC Roberts, Edinburgh, 1968
C14927	RNC_Mouse	Retired_Concepts	RNC Mouse|RNC
C14928	Wroclaw_U_Poland	Retired_Concepts	Wroclaw U, Poland
C14929	RW_Mouse	Retired_Concepts	RW Mouse|RW
C14930	Waltzing_Mice	Retired_Concepts	Waltzing Mice
C14931	TRE_Ko_Mouse	Retired_Concepts	TRE/Ko Mouse|TRE/Ko
C14932	KSB_NBR_Hybrids_1964	Retired_Concepts	KSB, NBR Hybrids, 1964
C14933	SIIT_Mouse	Retired_Concepts	SIIT Mouse|SIIT
C14934	Non_Inbred_Yellow_Stock	Retired_Concepts	Non Inbred Yellow Stock
C14935	BLN_Mouse	Retired_Concepts	BLN Mouse|BLN
C14936	Unknown_Origin_2	Retired_Concepts	Unknown Origin (2)
C14937	WHT_Mouse	Retired_Concepts	WHT Mouse|WHT
C14938	Outbred_NMRI_from_Bomholtgaard_Denmark	Retired_Concepts	Outbred NMRI from Bomholtgaard, Denmark
C14939	BOMG_Mouse	Retired_Concepts	BOMG Mouse|BOMG
C14940	Div_Lab_and_Res_State_Dept_Health_Albany_1930	Retired_Concepts	Div Lab and Res State Dept Health Albany, 1930
C14941	DMC_Mouse	Retired_Concepts	DMC Mouse|DMC
C14942	G_Bonser_Leeds_1932-36	Retired_Concepts	G Bonser, Leeds, 1932-36
C14943	IF_Mouse	Retired_Concepts	IF Mouse|IF
C14944	DS_Falconer_Edinburgh_Non-obese_Inbred_Stock	Retired_Concepts	DS Falconer, Edinburgh, Non-obese Inbred Stock
C14945	CN_Mouse	Retired_Concepts	CN Mouse|CN
C14946	Random_Inbred_Stock_JC_DeFries_Inst_Behav_Genet_Colorado	Retired_Concepts	Random Inbred Stock JC DeFries, Inst Behav Genet, Colorado
C14947	C1_Mouse	Retired_Concepts	C1 Mouse|C1
C14948	C2_Mouse	Retired_Concepts	C2 Mouse|C2
C14949	LC_Dunn_and_S_Gluecksohn-Waelsh_A_Einstein_Carries_Sd_Danforth_s_Short_Tail	Retired_Concepts	LC Dunn and S Gluecksohn-Waelsh, A Einstein, Carries Sd (Danforth's Short Tail)
C14950	SD_Mouse	Retired_Concepts	SD Mouse|SD
C14951	Hygiene_Inst_Zurich	Retired_Concepts	Hygiene Inst, Zurich
C14952	LIS_Mouse	Retired_Concepts	LIS Mouse|LIS
C14953	PE_RI	Retired_Concepts	PE/RI
C14954	_201_RI_Mouse	Retired_Concepts	201/RI Mouse|201/RI
C14955	A_y_a	Retired_Concepts	A^y/a
C14956	Outbred_Albino_Mice_C_Menendez_Cuba_1970	Retired_Concepts	Outbred Albino Mice, C Menendez, Cuba, 1970
C14957	IOR_Hab_Mouse	Retired_Concepts	IOR/Hab Mouse|IOR/Hab
C14958	PD_Forbes_Outbred_Pigmented_Mice	Retired_Concepts	PD Forbes Outbred Pigmented Mice
C14959	HRA_Skh	Retired_Concepts	HRA/Skh
C14960	HRA_Mouse	Retired_Concepts	HRA Mouse|HRA
C14961	SP_Homan_Florida_Mouse_Fancier	Retired_Concepts	SP Homan, Florida Mouse Fancier
C14962	KI_Mouse	Retired_Concepts	KI Mouse|KI
C14963	P_Loustalot_Ciba_Basel_1954	Retired_Concepts	P Loustalot, Ciba, Basel, 1954
C14964	LTS_Mouse	Retired_Concepts	LTS Mouse|LTS
C14965	Hy3_Mutn_in_Guy_s_Hosp_Stock_London	Retired_Concepts	Hy3 Mutn in Guy's Hosp. Stock London
C14966	SUMS_Mouse	Retired_Concepts	SUMS Mouse|SUMS
C14967	Oak_Ridge_1957_Tabby_circling_Stock	Retired_Concepts	Oak Ridge, 1957, Tabby/circling Stock
C14968	LST_Mouse	Retired_Concepts	LST Mouse|LST
C14969	Yellow_Lethal_Mice_Misima_1961	Retired_Concepts	Yellow Lethal Mice Misima, 1961
C14970	AY_Mouse	Retired_Concepts	AY Mouse|AY
C14971	LC_Strong	Retired_Concepts	LC Strong
C14972	STR_Mouse	Retired_Concepts	STR Mouse|STR
C14973	STR_1_Mouse	Retired_Concepts	STR/1 Mouse|STR/1
C14974	Albino_Stock_Pet_Shop_Birmingham_AL_1958	Retired_Concepts	Albino Stock, Pet Shop, Birmingham, AL 1958
C14975	PBA_Mouse	Retired_Concepts	PBA Mouse|PBA
C14976	PBB_Ld_Mouse	Retired_Concepts	PBB/Ld Mouse|PBB/Ld
C14977	VY_Wf-a_m_a_Male_Oakridge_1965_F5	Retired_Concepts	VY/Wf-a^m/a Male, Oakridge, 1965, F5
C14978	AM_Mouse	Retired_Concepts	AM Mouse|AM
C14979	VY_Wf-A_vy_aF12_GL_Wolff_Natl_Ctr_Toxicol_Res	Retired_Concepts	VY/Wf-A^vy/aF12, GL Wolff, Natl Ctr Toxicol Res
C14980	Ab_Griffen_Jax	Retired_Concepts	Ab Griffen, Jax
C14981	ABP_Le_Mouse	Retired_Concepts	ABP/Le Mouse|ABP/Le
C14982	Stock_Royal_Coll_Surgeons	Retired_Concepts	Stock Royal Coll Surgeons
C14983	ABH_Mouse	Inbred_Mouse	ABH Mouse|ABH
C14984	ABL_Mouse	Retired_Concepts	ABL Mouse|ABL
C14985	JW_Wilson_Brown_U_1950s	Retired_Concepts	JW Wilson, Brown U, 1950s
C14986	BUA_Mouse	Retired_Concepts	BUA Mouse|BUA
C14987	BUB_BnJ_Mouse	Inbred_Mouse	BUB/BnJ Mouse|BUB/BnJ
C14988	Pi_Stock_Mutn_Wl_wabbler_Lethal_1948	Retired_Concepts	Pi Stock Mutn Wl (wabbler Lethal), 1948
C14989	WLHR_Le_Mouse	Retired_Concepts	WLHR/Le Mouse|WLHR/Le
C14990	Polydactyl_Stock_PF_Forsthoefel_Detroit_U_1973	Retired_Concepts	Polydactyl Stock, PF Forsthoefel Detroit U, 1973
C14991	PF_Mouse	Retired_Concepts	PF Mouse|PF
C14992	JW_MacArthur_Stock_L_Butler_1949	Retired_Concepts	JW MacArthur Stock, L Butler, 1949
C14993	PHH_Mouse	Retired_Concepts	PHH Mouse|PHH
C14994	PHL_Mouse	Retired_Concepts	PHL Mouse|PHL
C14995	Random_Bred_ARC_Stock_Pre-1960	Retired_Concepts	Random Bred ARC Stock, Pre-1960
C14996	VL_Mouse	Retired_Concepts	VL Mouse|VL
C14997	JW_MacArthur_Toronto_Outbred_T_Stock	Retired_Concepts	JW MacArthur, Toronto Outbred T Stock
C14998	TH_Mouse	Retired_Concepts	TH Mouse|TH
C14999	TL_Mouse	Retired_Concepts	TL Mouse|TL
C15000	Carworth_Farms	Retired_Concepts	Carworth Farms
C15001	ICFW_Mouse	Retired_Concepts	ICFW Mouse|ICFW
C15002	CFW_Mouse	Retired_Concepts	CFW Mouse|CFW
C15003	CF1_Mouse	Retired_Concepts	CF1 Mouse|CF1
C15004	CF0_Mouse	Retired_Concepts	CF0 Mouse|CF0
C15005	Unknown_Origin_Rockland_USA	Retired_Concepts	Unknown Origin, Rockland USA
C15006	RAP_Ko_Mouse	Retired_Concepts	RAP/Ko Mouse|RAP/Ko
C15007	AL_Hagedoorn_Neth	Retired_Concepts	AL Hagedoorn, Neth
C15008	QC_Mouse	Retired_Concepts	QC Mouse|QC
C15009	Outbred_Mice_Carworth_Farms	Retired_Concepts	Outbred Mice, Carworth Farms
C15010	CFCW_Mouse	Retired_Concepts	CFCW Mouse|CFCW
C15011	Outbred_Charles_River_USA	Retired_Concepts	Outbred, Charles River USA
C15012	MIW_Mouse	Retired_Concepts	MIW Mouse|MIW
C15013	B6CBA-ch_congenital_Hydrocephalus_H_Gruneburg	Retired_Concepts	B6CBA-ch (congenital Hydrocephalus), H Gruneburg
C15014	CHMU_Le_Mouse	Retired_Concepts	CHMU/Le Mouse|CHMU/Le
C15015	G_Rudali_Fond_Curie_1956	Retired_Concepts	G Rudali, Fond Curie, 1956
C15016	NLC_Mouse	Retired_Concepts	NLC Mouse|NLC
C15017	Seven-locus_Stock_M_Lyon_Harwell_1969	Retired_Concepts	Seven-locus Stock, M Lyon, Harwell, 1969
C15018	PT_Mouse	Retired_Concepts	PT Mouse|PT
C15019	Dobrovlskaia-Zavadskaia_Paris_1928	Retired_Concepts	Dobrovlskaia-Zavadskaia Paris, 1928
C15020	XVII_Mouse	Retired_Concepts	XVII Mouse|XVII
C15021	XLII_Mouse	Retired_Concepts	XLII Mouse|XLII
C15022	Unknown_Origin_3	Retired_Concepts	Unknown Origin (3)
C15023	X_Mouse	Retired_Concepts	X Mouse|X
C15024	Outbred_TO-Crm_cream_Mutn_Harwell_1987	Retired_Concepts	Outbred TO-Crm (cream) Mutn, Harwell, 1987
C15025	CRM_Mouse	Retired_Concepts	CRM Mouse|CRM
C15026	Danish_White_Mice_MRS_Street_1932	Retired_Concepts	Danish White Mice MRS Street, 1932
C15027	ST_Simonex_Heston_Jax_Substrains_Mouse	Retired_Concepts	ST Simonex, Heston, Jax Substrains Mouse|ST Simonex, Heston, Jax Substrains
C15028	K_Mouse	Retired_Concepts	K Mouse|K
C15029	LC_Strong_2	Retired_Concepts	LC Strong (2)
C15030	English_Fancier_before_1929	Retired_Concepts	English Fancier before 1929
C15031	DW_J_Mouse	Inbred_Mouse	DW/J Mouse|DW/J
C15032	HG_Goodale	Retired_Concepts	HG Goodale
C15033	G_Mouse	Retired_Concepts	G Mouse|G
C15034	Random_Bred_Fawn-coloured_Mice_1953	Retired_Concepts	Random Bred Fawn-coloured Mice, 1953
C15035	OUF_Mouse	Retired_Concepts	OUF Mouse|OUF
C15036	Varicoloured_Random_Bred_Mice_UK_1939	Retired_Concepts	Varicoloured Random Bred Mice, UK, 1939
C15037	OUYW_Mouse	Retired_Concepts	OUYW Mouse|OUYW
C15038	Mutn_to_Sa_satin_and_Bg_beige_Oak_Ridge	Retired_Concepts	Mutn to Sa (satin) and Bg (beige), Oak Ridge
C15039	Sb_Le_Mouse	Retired_Concepts	Sb/Le Mouse|Sb/Le
C15040	Dealer_to_RG_Schott_1927	Retired_Concepts	Dealer to RG Schott, 1927
C15041	S_Mouse	Retired_Concepts	S Mouse|S
C15042	Albino_Mice	Retired_Concepts	Albino Mice
C15043	LG_J_Mouse	Inbred_Mouse	LG/J Mouse|LG/J
C15044	Female_Tfm_plus_X_Ta_Y_Male_1971	Retired_Concepts	Female Tfm/+ X Ta/Y Male 1971
C15045	TFM_Mouse	Retired_Concepts	TFM Mouse|TFM
C15046	Outbred_T_Tf_plus_Tf_Stock	Retired_Concepts	Outbred T, Tf/+, Tf Stock
C15047	TFH_Mouse	Retired_Concepts	TFH Mouse|TFH
C15048	Dealer_1922	Retired_Concepts	Dealer 1922
C15049	PL_J_Mouse	Inbred_Mouse	PL/J Mouse|PL/J
C15050	Imported_to_Australia_1928	Retired_Concepts	Imported to Australia 1928
C15051	STUD_Mouse	Retired_Concepts	STUD Mouse|STUD
C15052	B6D2F1J-mk_microcytic_Anemia_Mutn_MM_Dickie_Jax	Retired_Concepts	B6D2F1J-mk (microcytic Anemia) Mutn MM Dickie, Jax
C15053	MH_Mouse	Retired_Concepts	MH Mouse|MH
C15054	Unknown_Origin_4	Retired_Concepts	Unknown Origin (4)
C15055	STOLI_Mouse	Retired_Concepts	STOLI Mouse|STOLI
C15056	Non_Inbred_Obese_Stock_DS_Falconer_Edinburgh_1958	Retired_Concepts	Non Inbred Obese Stock DS Falconer, Edinburgh 1958
C15057	BA_Mouse	Retired_Concepts	BA Mouse|BA
C15058	H_Krzanowska_Krakow_1952	Retired_Concepts	H Krzanowska, Krakow, 1952
C15059	KP_Mouse	Retired_Concepts	KP Mouse|KP
C15060	KE_Mouse	Retired_Concepts	KE Mouse|KE
C15061	Outbred_Defence_Res_BD_Suffield_Alberta	Retired_Concepts	Outbred Defence Res BD Suffield, Alberta
C15062	SWV_Mouse	Inbred_Mouse	SWV Mouse|SWV
C15063	Albino_Mice_Hyg_INst_Zurich_1955	Retired_Concepts	Albino Mice, Hyg INst Zurich, 1955
C15064	STS_Mouse	Retired_Concepts	STS Mouse|STS
C15065	Unknown_Origin_HG_Wolfe_Kansas_U_1970s	Retired_Concepts	Unknown Origin, HG Wolfe, Kansas U, 1970s
C15066	QF-5604_Mouse	Retired_Concepts	QF-5604 Mouse|QF-5604
C15067	QF-5612_Mouse	Retired_Concepts	QF-5612 Mouse|QF-5612
C15068	Outbred_Mice_NMRI_Bethesda	Retired_Concepts	Outbred Mice NMRI Bethesda
C15069	MIG_Mouse	Retired_Concepts	MIG Mouse|MIG
C15070	Jax_Grey_Lethal_Mutn	Retired_Concepts	Jax Grey Lethal Mutn
C15071	GLF_Y_Mouse	Retired_Concepts	GLF/Y Mouse|GLF/Y
C15072	Outbred_Mice_Grumbach_Zurich	Retired_Concepts	Outbred Mice Grumbach, Zurich
C15073	MAS_Mouse	Retired_Concepts	MAS Mouse|MAS
C15074	GRS_Mouse	Retired_Concepts	GRS Mouse|GRS
C15075	B_Cattanach_Harwell_C3H_HeH_X_101H_F1-hpg_hypogonadal_Mutn	Retired_Concepts	B Cattanach, Harwell (C3H/HeH X 101H) F1-hpg (hypogonadal) Mutn
C15076	HPG_Mouse	Retired_Concepts	HPG Mouse|HPG
C15077	FAE_Crew_1925	Retired_Concepts	FAE Crew, 1925
C15078	HR_De_Mouse	Retired_Concepts	HR/De Mouse|HR/De
C15079	HRS_Mouse	Retired_Concepts	HRS Mouse|HRS
C15080	HR_Ri_Mouse	Retired_Concepts	HR/Ri Mouse|HR/Ri
C15081	Inbred_Strains_Freiburg_U_1938	Retired_Concepts	Inbred Strains, Freiburg U, 1938
C15082	HLG_Mouse	Retired_Concepts	HLG Mouse|HLG
C15083	H_Gruneberg_Stock_Tyr_c-e_Gl_grey_Lethal_Mutn_U_Coll_London_1935	Retired_Concepts	H Gruneberg Stock Tyr^c-e Gl (grey Lethal) Mutn, U Coll London, 1935
C15084	GL_Le_Mouse	Retired_Concepts	GL/Le Mouse|GL/Le
C15085	A_J-Mip_Cat_Fr_Mutn_McGill_U_1966	Retired_Concepts	A/J-Mip^Cat_Fr Mutn, McGill U, 1966
C15086	CA_Mouse	Retired_Concepts	CA Mouse|CA
C15087	Commercial_Dealer_Oslo	Retired_Concepts	Commercial Dealer Oslo
C15088	WLL_Mouse	Retired_Concepts	WLL Mouse|WLL
C15089	WLO_Mouse	Retired_Concepts	WLO Mouse|WLO
C15090	DS_Falconer_Edinburgh	Retired_Concepts	DS Falconer, Edinburgh
C15091	NAKED_Mouse	Retired_Concepts	NAKED Mouse|NAKED
C15092	Breeder_Albany_NY_1930	Retired_Concepts	Breeder, Albany, NY 1930
C15093	NYLR_Mouse	Retired_Concepts	NYLR Mouse|NYLR
C15094	Carworth_Farms_CF-1	Retired_Concepts	Carworth Farms CF-1
C15095	NRH_Mouse	Retired_Concepts	NRH Mouse|NRH
C15096	DS_Falconer_Edinburgh_2	Retired_Concepts	DS Falconer, Edinburgh (2)
C15097	J_Mouse	Retired_Concepts	J Mouse|J
C15098	JBT_Jd_Mouse	Retired_Concepts	JBT/Jd Mouse|JBT/Jd
C15099	VM_X_Linkage_Marker_Stock_Moredun_Res_Inst_Edinburgh	Retired_Concepts	VM X Linkage Marker Stock, Moredun Res Inst, Edinburgh
C15100	LM_Mouse	Retired_Concepts	LM Mouse|LM
C15101	MM_Mouse	Retired_Concepts	MM Mouse|MM
C15102	Albino_Mice_NZ_Pet_Shop_1948	Retired_Concepts	Albino Mice, NZ Pet Shop, 1948
C15103	P_Mouse	Retired_Concepts	P Mouse|P
C15104	Unknown_Origin_5	Retired_Concepts	Unknown Origin (5)
C15105	RIIl_J	Retired_Concepts	RIIl/J
C15106	RIIlS_J_Mouse	Retired_Concepts	RIIlS/J Mouse|RIIlS/J
C15107	Wild_Mutant_Trapped_in_Illinois_by_Knight_1920	Retired_Concepts	Wild Mutant Trapped in Illinois by Knight, 1920
C15108	DE_J_Mouse	Retired_Concepts	DE/J Mouse|DE/J
C15109	CE_J_Mouse	Inbred_Mouse	CE/J Mouse|CE/J
C15110	Unspecified_Stock_A_Bluhm	Retired_Concepts	Unspecified Stock, A Bluhm
C15111	AB_Mouse	Retired_Concepts	AB Mouse|AB
C15112	Stock_RA_Fisher_Cambridge	Retired_Concepts	Stock RA Fisher, Cambridge
C15113	JE_Le_Mouse	Retired_Concepts	JE/Le Mouse|JE/Le
C15114	Non_Inbred_Obese_Stock_Atp7a_Mo-to_tortoise_Mutn	Retired_Concepts	Non Inbred Obese Stock Atp7a^Mo-to (tortoise) Mutn
C15115	TR	Retired_Concepts	TR
C15116	TT6_Mouse	Retired_Concepts	TT6 Mouse|TT6
C15117	Texas_A_and_M_Outbred_SENCAR_Stock_1970s	Retired_Concepts	Texas A and M Outbred SENCAR Stock 1970s
C15118	SSIN_Mouse	Retired_Concepts	SSIN Mouse|SSIN
C15119	Iffa_Credo_France	Retired_Concepts	Iffa Credo, France
C15120	UMDH_plus_Mouse	Retired_Concepts	UMDH/+ Mouse|UMDH/+
C15121	UMS_Mouse	Retired_Concepts	UMS Mouse|UMS
C15122	Central_Proefdierenbedrijf_TNO_Holland_1950	Retired_Concepts	Central Proefdierenbedrijf TNO Holland, 1950
C15123	CPB-X_Mouse	Retired_Concepts	CPB-X Mouse|CPB-X
C15124	CPB-Q_Mouse	Retired_Concepts	CPB-Q Mouse|CPB-Q
C15125	CPB-N_Mouse	Retired_Concepts	CPB-N Mouse|CPB-N
C15126	CPB-F_Mouse	Retired_Concepts	CPB-F Mouse|CPB-F
C15127	CPB-MO_Mouse	Retired_Concepts	CPB-MO Mouse|CPB-MO
C15128	CPB-M_Mouse	Retired_Concepts	CPB-M Mouse|CPB-M
C15129	CPB-T	Retired_Concepts	CPB-T
C15130	CPB-TK_Mouse	Retired_Concepts	CPB-TK Mouse|CPB-TK
C15131	CPB-K	Retired_Concepts	CPB-K
C15132	CPB-WG_Mouse	Retired_Concepts	CPB-WG Mouse|CPB-WG
C15133	CPB-H_Mouse	Retired_Concepts	CPB-H Mouse|CPB-H
C15134	Utrecht	Retired_Concepts	Utrecht
C15135	NCU_CpbU_Mouse	Retired_Concepts	NCU/CpbU Mouse|NCU/CpbU
C15136	HC_Mouse	Retired_Concepts	HC Mouse|HC
C15137	MOC_Mouse	Retired_Concepts	MOC Mouse|MOC
C15138	FTC_Mouse	Retired_Concepts	FTC Mouse|FTC
C15139	PC_CpbU_Mouse	Retired_Concepts	PC/CpbU Mouse|PC/CpbU
C15140	RC_Mouse	Retired_Concepts	RC Mouse|RC
C15141	VC_Mouse	Retired_Concepts	VC Mouse|VC
C15142	H_Gruneberg_UCL	Retired_Concepts	H Gruneberg, UCL
C15143	CPB-WV_Mouse	Retired_Concepts	CPB-WV Mouse|CPB-WV
C15144	N_Kobozieff_Alfort_France_1949	Retired_Concepts	N Kobozieff, Alfort, France, 1949
C15145	MO_Mouse	Retired_Concepts	MO Mouse|MO
C15146	RB_8_17_1Lem_Arose_in_White_Mice_at_Inst_Med_Leningrad_Rappolovo_Nursery	Retired_Concepts	RB (8.17)1Lem Arose in White Mice at Inst Med Leningrad, Rappolovo Nursery
C15147	RBC_Dn_Mouse	Retired_Concepts	RBC/Dn Mouse|RBC/Dn
C15148	Common_Inbred_Mouse_Strains	Retired_Concepts	Common Inbred Mouse Strains
C15149	Unsorted_Inbred_Strains	Retired_Concepts	Unsorted Inbred Strains
C15150	Common_Mouse_Strains	Retired_Concepts	Common Mouse Strains
C15151	_129_Mouse	Inbred_Mouse	129 Mouse|129	Inbr and colour depends on substrain (see below). Origin: Dunn 1928 from crosses of coat colour stocks from English fanciers and a chinchilla stock from Castle. This strain has a common origin with strain 101. Most substrains carry the white-bellied agouti gene AW though only a subset have the agouti pattern as many carry albino or chinchilla and/or the pink-eyed dilution gene, p, which is derived from Asian mice of the Mus musculus type (see also strains SJL, P/J and FS/Ei). (Jackson Labs/Festing)
C15152	CD-1_Nude_Mouse	Nude_Mouse	CD-1 Nude Mouse|CD-1 Nude|Cr1:CD-1 -nuBR
C15153	BALB_c_Nude_Mouse	Nude_Mouse	BALB/c Nude Mouse|BALB/c Nude|BALB/cAnNCr1-nuBR
C15154	NIH-III_Mouse	Immunodeficient_Mouse	NIH-III Mouse|N:NIH-bg-nu-xidBR|NIH-III
C15155	NU_NU_Mouse	Nude_Mouse	NU/NU Mouse|Crl:NU/NU-nuBR|NU/NU
C15156	Immunodeficient_Mouse	Mouse_Strains	Immunodeficient Mouse
C15157	Rag1_Mouse	Immunodeficient_Mouse	Rag1 Mouse|Rag1
C15158	Fox_Chase_SCID_Mouse	SCID_Mouse	Fox Chase SCID Mouse|C.B-17/IcrCrl-scid-BR|Fox Chase SCID
C15159	SCID_Beige_Mouse	SCID_Mouse	SCID Beige Mouse|C.B-17/IcrCrl-scid-bgBR|CB-17/IcrCrl-scid-bgBR|SCID Beige
C15160	B6_Cg-Foxn1-nu_Mouse	Nude_Mouse	B6.Cg-Foxn1-nu Mouse|B6.Cg-Foxn1-nu|C57BL/6J-Hfh1l-nu
C15161	CBy_Cg-Foxn1-nu	Nude_Mouse	CBy.Cg-Foxn1-nu|BALB/cByJ-Hfh1l-nu
C15162	CByB6F1_J-Foxn1-nu_Mouse	Nude_Mouse	CByB6F1/J-Foxn1-nu Mouse|CByB6F1/J-Foxn1-nu|CByB6F1/J-Hfh1l-nu
C15163	NU_J_Foxn1-nu_Mouse	Nude_Mouse	NU/J Foxn1-nu Mouse|NU/J Foxn1-nu|NU/J Hfh1l-nu
C15164	CBySmn_CB17-Prkdc-scid_J_Mouse	SCID_Mouse	CBySmn.CB17-Prkdc-scid/J Mouse|BALB/cBySmn-Prkdc-scid/J|CBySmn.CB17-Prkdc-scid/J
C15165	C3Smn_CB17-Prkdc-scid_J_Mouse	SCID_Mouse	C3Smn.CB17-Prkdc-scid/J Mouse|C3Smn.C-Prkdc-scid/J|C3Smn.CB17-Prkdc-scid/J
C15166	B6_CB17-Prkdc-scid_SzJ_Mouse	SCID_Mouse	B6.CB17-Prkdc-scid/SzJ Mouse|B6.CB17-Prkdc-scid/SzJ|C57BL/6J-Prkdc-scid/SzJ
C15167	NOD_CB17-Prkdc-scid_J_Mouse	SCID_Mouse	NOD.CB17-Prkdc-scid/J Mouse|NOD.CB17-Prkdc-scid/J|NOD/LtSz-Prkdc-scid/J
C15168	NOD_129S7_B6_Rag1-tm1Mom_Mouse	Rag1_Mouse	NOD.129S7(B6)-Rag1-tm1Mom Mouse|NOD.129S7(B6)-Rag1-tm1Mom|NOD/LtSz-Rag1-tm1Mom
C15169	C_129S7-Rag1-tm1Mom_Mouse	Rag1_Mouse	C.129S7-Rag1-tm1Mom Mouse|BALB/c-Rag1-tm1Mom|C.129S7-Rag1-tm1Mom
C15170	B6_129-Rag1-tm1Mom_Mouse	Rag1_Mouse	B6;129-Rag1-tm1Mom Mouse|B6,129-Rag1-tm1Mom|B6;129-Rag1-tm1Mom
C15171	B6_129S7-Rag1-tm1Mom_Mouse	Rag1_Mouse	B6.129S7-Rag1-tm1Mom Mouse|B6.129S7-Rag1-tm1Mom|C57BL/6J-Rag1-tm1Mom
C15172	Common_Rattus_Norvegicus_Strains	Rat_Strains	Common Rattus Norvegicus Strains
C15173	CD80_Antigen	Cell_Adhesion_Molecule	CD80 Antigen|B-lymphocyte Activation Antigen B7-1|B7|B7-1|B71 Antigen|BB1|CD28 Antigen Ligand 1|CD28LG|CD28LG1|CD80|LAB7	A member of the immunoglobulin gene super family.  Co-regulator of T cell activation with CD86.  Plays a critical role in autoimmune, humoral, and transplant responses.  Expressed on activated T and B cells and on macrophages.  (from PROW)
C15174	CD2_Antigen	Cell_Adhesion_Molecule	CD2 Antigen|CD2|CD2R|E-Rosette Receptor|Lymphocyte-Function Antigen-2, LFA-2|Sheep Red Blood Cell Receptor	An antigen that functions as a co-receptor or accessory molecule in the T-cell receptor complex, which is involved in helper and cytotoxic T-lymphocyte adhesion and activation. The molecule is expressed on the cell surface of the majority of peripheral T-lymphocytes, NK cells, and thymocytes.
C15175	HIV_Positive	Abnormal_Blood_and_Hematology_Test_Result	HIV Positivity|HIV Positive
C15176	Acupuncture	Treatment	Acupuncture|acupuncture	Technique for treating certain painful conditions and for producing regional anesthesia by passing long thin needles through the skin to specific points.  The free ends of the needles are twirled or in some cases used to conduct a weak electric current. Anesthesia sufficient to permit abdominal, thoracic, and head and neck surgery has been produced by the use of acupuncture alone. The patient is fully conscious during the surgery. Acupuncture has been known in the Far East for centuries but received little attention in Western cultures until the early 1970s. (Taber's)
C15177	Adrenalectomy	Abdominal_Surgical_Procedures	Adrenalectomy|Adrenal Gland Excision|Excision of Adrenal Gland
C15178	Complementary_and_Alternative_Medicine	Clinical_or_Research_Activity	Complementary and Alternative Medicine|Alternative Therapy|CAM|alternative medicine|complementary and alternative medicine|complementary medicine	A classification system with 7 major categories and 18 sub-categories for operationalizing research agendas.  Major categories include: Mind-body medicine (with OBSSR); Alternative medical systems; Lifestyle & disease prevention (with ODP); Biological based therapies (with ODS); Manipulative and body based systems; Biofields; and Bioelectro-magnetics.
C15179	Amputation	Surgical_Procedure	Amputation|amputation	(am-pyoo-TAY-shun) Surgery to remove part or all of a limb or appendage.
C15180	Pain_Therapy	Palliative_Care	Pain Therapy|Analgesia|Pain Control|Pain Management|Pain, Pain Management	(i) the systematic study of clinical and basic science and its application for the reduction of pain and suffering; (ii) the blending of tools, techniques and principles taken from the discrete healing art disciplines and reformulated as a holistic application for the reduction of pain and suffering; and (iii) a newly emerging discipline emphasizing an interdisciplinary approach with a goal of reduction of pain and suffering. (AAPM)
C15181	Anesthesia_Procedure	Procedure	Anesthesia Procedure|Anesthesia|anesthesia	(an-es-THEE-zha) Drugs or substances that cause loss of feeling or awareness. Local anesthetics cause loss of feeling in a part of the body. General anesthetics put the person to sleep.
C15182	Animal_Testing_Alternatives	Research	Animal Testing Alternatives|Animal Alternatives	Methods which refine, reduce, or replace the use of animals in research. (from CSP2000)
C15183	Antimetabolite_Chemotherapy	Cancer_Treatment	Antimetabolite Chemotherapy|Chemotherapy, Antimetabolites|Chemotherapy, Cancer, Antimetabolites	Treatment of cancer that utilizes antimetabolite chemicals.
C15184	Behavioral_Intervention	Treatment	Behavioral Intervention|Behavior Conditioning Therapy|Behavior Modification|Behavior Therapy|Behavior or Life Style Modifications|Behavioral Interventions|Behavioral Modification|Behavioral Therapy|Behavioral Treatment|Behavioral Treatments	The use of operant conditioning, including rewards and punishments, in helping a person create an atmosphere where he or she does not contribute to painful stimuli.
C15185	Behavioral_Research	Population_Study	Behavioral Research	Studies of motivating factors influencing health practices as well as efforts to modify these practices.
C15186	Biofeedback	Mind-Body_Intervention	Biofeedback|biofeedback	A method of learning to voluntarily control certain body functions such as heartbeat, blood pressure, and muscle tension with the help of a special machine.  This method can help control pain.
C15187	Biological_Therapy	Treatment	Biological Therapy|Biological Response Modifier Therapy|Biological Response Modifiers Therapy|Biologics Therapies|Biotherapy|biological therapy|biotherapy	(by-o-LAHJ-i-kul...)Treatment to stimulate or restore the ability of the immune system to fight infections and other diseases. Also used to lessen side effects that may be caused by some cancer treatments.
C15188	Biomedical_Research	Research	Biomedical Research
C15189	Biopsy	Surgical_Procedure	Biopsy|BX|biopsy	(BY-op-see) The removal of cells or tissues for examination under a microscope. When only a sample of tissue is removed, the procedure is called an incisional biopsy or core biopsy. When an entire lump or suspicious area is removed, the procedure is called an excisional biopsy. When a sample of tissue or fluid is removed with a needle, the procedure is called a needle biopsy or fine-needle aspiration.
C15190	Needle_Biopsy	Biopsy	Needle Biopsy|Aspiration Biopsy|Puncture Biopsy|needle biopsy	The removal of tissue or fluid with a needle for examination under a microscope.
C15191	Pheresis	Procedure	Pheresis|Apheresis|Blood Component Removal|Hemapheresis|apheresis|pheresis	(fer-E-sis) A procedure in which blood is collected, part of the blood such as platelets or white blood cells is taken out, and the rest of the blood is returned to the donor.
C15192	Blood_Transfusion	Transfusion	Blood Transfusion|Blood Component Transfusion|blood transfusion	The administration of blood or blood products into a blood vessel.
C15193	Bone_Marrow_Biopsy	Biopsy	Bone Marrow Biopsy|Biopsy, Bone Marrow|biopsy of bone marrow|bone marrow biopsy	(BY-op-see) The removal of a sample of tissue from the bone marrow with a needle for examination under a microscope.
C15194	Bone_Marrow_Transplantation	Cancer_Treatment|Transplantation	Bone Marrow Transplantation|BMT|Bone Marrow Grafting|Bone Marrow Transplant|Marrow Transplantation|bone marrow transplantation	(trans-plan-TAY-shun) A procedure to replace bone marrow destroyed by treatment with high doses of anticancer drugs or radiation.
C15195	Radiation_Brachytherapy	Local_Therapy|Radiation_Therapy	Radiation Brachytherapy|BRT|Brachytherapy|Implant Radiation|Internal Radiation|implant radiation	(ray-dee-AY-shun) A procedure in which radioactive material sealed in needles, seeds, wires, or catheters is placed directly into or near a tumor. Also called brachytherapy, internal radiation, or interstitial radiation.
C15196	Carcinogenicity_Test	Carcinogen_Screening	Carcinogenicity Test
C15197	Case-Control_Study	Case_Study	Case-Control Study
C15198	Surgical_Castration	Urogenital_Surgical_Procedure	Surgical Castration|Castration|castration|surgical castration	Removal or destruction of the testicles or ovaries using radiation, surgery, or drugs. Medical castration refers to the use of drugs to suppress the function of the ovaries or testicles.
C15199	Cauterization	Surgical_Procedure	Cauterization|cauterization|cautery	(KAW-ter-ih-ZAY-shun) The destruction of tissue with a hot instrument, an electrical current, or a caustic substance.
C15200	cecostomy	Colon_and_Rectal_Surgery|Ostomy	cecostomy
C15201	Cell-free_System	in_vitro_Assay	Cell-free System	experimental condition created by disrupting cells with homogenization, sonication, detergents, or other treatment, leaving intracellular components exposed to controlled manipulation of the medium.
C15202	Child_Development	Child_Health	Child Development|Infant and Child Development	The process by which a child acquires social, emotional, intellectual, motor, speech, and language skills.
C15203	Child_Health	Maternal_and_Child_Health	Child Health	THe medical speciality addressed in pediatrics.
C15204	Chiropractic_Medicine	Manipulative_and_Body-Based_Methods	Chiropractic Medicine	A system of treatment based on the manipulation of the spinal vertebrae, the misalignment of which is believed to be responsible for pain and illness.
C15205	Nutrition_Cholesterol	Nutrition_Dietary_Components	Nutrition, Cholesterol|Lipid Nutrition, Cholesterol	Role of cholesterol in cancer causation or prevention and in general health.
C15206	Clinical_Study	Research	Clinical Study|Clinical Research|Clinical Studies|Study|clinical study	A type of research study that tests how well new medical treatments or other interventions work in people.  Such studies test new methods of screening, prevention, diagnosis, or treatment of a disease.  The study may be carried out in a clinic or other medical facility.  Also called a clinical trial.
C15207	Clinical_Trial	Clinical_Study	Clinical Trial|Clinical Trials|Clinical Trials, Unspecified|Trial|clinical trial	A clinical trial is a controlled study performed in human subjects and intended to discover, and/or evaluated, and/or verify safety, effectiveness, clinical and pharmacological effects, and adverse reactions of new drugs, devices, treatments, preventive measures, or other medical interventions in treating, preventing, or diagnosing a specific disease or condition.
C15208	Cohort_Study	Longitudinal_Study	Cohort Study
C15209	Colectomy	Colon_and_Rectal_Surgery	Colectomy|colectomy	(ko-LEK-toe-mee) An operation to remove the colon. An open colectomy is the removal of the colon through a surgical incision made in the wall of the abdomen. Laparoscopic-assisted colectomy uses a thin, lighted tube attached to a video camera. It allows the surgeon to remove the colon without a large incision.
C15210	Colon_and_Rectal_Surgery	Abdominal_Surgical_Procedures|Digestive_System_Surgery	Colon and Rectal Surgery|colon and rectum surgery|colorectal surgery
C15211	Colostomy	Colon_and_Rectal_Surgery|Ostomy	Colostomy|colostomy	(ko-LAHS-toe-mee) An opening into the colon from the outside of the body. A colostomy provides a new path for waste material to leave the body after part of the colon has been removed.
C15212	Multimodal_Therapy	Treatment	Multimodal Therapy|Combined Treatment Modalities|Multimodality Treatment|combination therapy|combined modality therapy|combined modality treatment|combined treatment|multimodal treatment|multimodality treatment	Therapy that combines more than one method of treatment.
C15213	Community_Health_Services	Clinical_Services	Community Health Services	Diagnostic, therapeutic and preventive health services provided for individuals in the community.
C15214	Craniotomy	Head_and_Neck_Surgery	Craniotomy|craniotomy|incision of the skull	(kray-nee-AH-toe-mee) An operation in which an opening is made in the skull.
C15215	Cryosurgery	Surgical_Procedure	Cryosurgery|Cryoablation|cryosurgery	(KRYE-o-SIR-jer-ee) Treatment performed with an instrument that freezes and destroys abnormal tissues.
C15216	Curettage_Procedure	Surgical_Procedure	Curettage Procedure|Curettage|curettage	(kyoo-reh-TAHZH) Removal of tissue with a curette, a spoon-shaped instrument with a sharp edge.
C15217	Cystectomy	Urologic_Surgical_Procedure	Cystectomy|CYSTEC|cystectomy	(sis-TEK-toe-mee) Surgery to remove all or part of the bladder.
C15218	Cystostomy	Urostomy	Cystostomy|Vesicostomy
C15219	Health_Care_Delivery	Healthcare_Activity	Health Care Delivery|Care Delivery|Health Sciences, Allied and Health Services Delivery|Healthcare Delivery	The provision of medical care.
C15220	Diagnosis	Clinical_or_Research_Activity	Diagnosis|DX|diagnosis	The investigation, analysis and recognition of the presence and nature of disease, condition, or injury from expressed signs and symptoms; also, the scientific determination of any kind; the concise results of such an investigation.
C15221	Dialysis	Blood_Treatment	Dialysis|Dialysis Procedure|Dialysis Therapy|dialysis	(dye-AL-ih-sis) The process of cleansing the blood when the kidneys are not able to filter the blood.
C15222	Diet	Diet_and_Nutrition	Diet|diet	The customary allowance of food and drink taken by a person or an animal from day to day, particularly one especially planned to meet specific requirements of the individual, including or excluding certain items of food; a prescribed course of eating and drinking in which the amount and kind of food, as well as the times at which it is to be taken, are regulated for therapeutic purposes or selected with reference to a particular state of health.
C15223	Nutrition_Carbohydrates	Nutrition_Dietary_Components	Nutrition, Carbohydrates|Carbohydrate Nutrition	Role of carbohydrates in cancer causation or prevention and in general health.
C15224	Nutrition_Fats	Nutrition_Dietary_Components	Nutrition, Fats|Dietary Fat|Lipid Nutrition, Fats	Role of dietary fats in cancer causation or prevention and in general health.
C15225	Nutrition_Fiber	Nutrition_Dietary_Components	Nutrition, Fiber	Role of dietary fiber in cancer causation or prevention and in general health.
C15226	Dilation_and_Curettage	Curettage_Procedure	Dilation and Curettage|D and C|D&C|Dilation and Curettage of the Uterus|Uterine Endometrectomy|dilation and curettage	(dye-LAY-shun and kyoo-reh-TAHZH) D&C. A minor operation in which the cervix is expanded enough (dilation) to permit the cervical canal and uterine lining to be scraped with a spoon-shaped instrument called a curette (curettage).
C15227	Dissection	Surgical_Procedure	Dissection|DISSEC	The process of cutting apart or separating tissue as, for example, in the study of anatomy or in the course of a surgical procedure. (MedicineNet.com)
C15228	Double_Blind_Study	Study_Design	Double Blind Study|Double-Blinded|double-blinded	A clinical trial in which neither the medical staff nor the person knows which of several possible therapies the person is receiving.
C15229	Drug_Screening_Assay_Antitumor	Drug_Development	Antitumor Drug Screening Assay|Drug Screening Assays, Antitumor
C15230	Embolization_Therapy	Local_Therapy	Embolization Therapy|embolization|therapy, embolization	(EM-bo-lih-ZAY-shun) The blocking of an artery by a clot or foreign material. Embolization can be done as treatment to block the flow of blood to a tumor.
C15231	Estrogen_Replacement_Therapy	Estrogen_Therapy|Postmenopausal_Hormone_Replacement_Therapy	Estrogen Replacement Therapy|ERT|Estrogen Replacement|estrogen replacement therapy	Hormones (estrogen, progesterone, or both) given to postmenopausal women or to women who have had their ovaries surgically removed. Hormones are given to replace the estrogen no longer produced by the ovaries.
C15232	Excision	Surgical_Procedure	Excision|Abscission|Extirpation|RES|Removal|Resection|Surgical Removal|excision|resection	(ree-SEK-shun) Removal of tissue or part or all of an organ by surgery.
C15233	Nutrition_Fats_Unsaturated	Nutrition_Fats	Nutrition, Fats, Unsaturated|Lipid Nutrition, Unsaturated	Role of unsaturated fats in cancer causation or prevention and in general health.
C15234	Follow-up_Study	Clinical_Study	Follow-up Study	Study in which persons exposed to risk or given a designated preventive or therapeutic regimen are observed over a period or at intervals to determine the outcome of the exposure or regimen. (On-line Medical Dictionary)
C15235	Nutrition_Food_Additives	Nutrition_Dietary_Components	Nutrition, Food Additives	Role of food additives in cancer causation or prevention and in general health.
C15236	Gastrectomy	Abdominal_Surgical_Procedures|Digestive_System_Surgery	Gastrectomy|gastrectomy	(gas-TREK-toe-mee) An operation to remove all or part of the stomach.
C15237	Gene_Bank	Library	Gene Bank	A stored copy of genetic information of a species in a preferred environment for conservation purposes. (biology-online.org)
C15238	Gene_Therapy	Biological_Therapy	Gene Therapy|DNA Therapy|GENE-TX|Gene Transfer Procedure|Intervention, Genetic|Molecular Biology, Gene Therapy|gene therapy	Application of genetic material (usually DNA) into cells in order to permanently correct an inherited disease or an acquired disease such as cancer.  The genetic material as 'naked' DNA can be delivered into the cells alone or can be delivered into cells by different types of vectors such as viruses which may contain DNA or RNA.  Gene therapy techniques attempt to replace a faulty/missing gene associated with a particular disease, mediate localized delivery of a protein producing specified therapeutic effects, or introduce new cellular functions.  Gene therapies are designed to deliver genetic material into somatic cells and not germ cells, so that only cells of patients and not those of their offspring contain and express the genetic material delivered. (NCI04)
C15239	Patient_Care	Healthcare_Activity	Patient Care|Patient Care Delivery	The concept concerned with all aspects of providing and distributing health services to a patient population.
C15240	Genetic_Counseling	Community_Health_Services	Genetic Counseling|genetic counseling	A communication process between a specially trained health professional and a person concerned about the genetic risk of disease.  The person's family and personal medical history may be discussed, and counseling may lead to genetic testing.
C15241	Genomic_Library	Library	Genomic Library	A collection of DNA molecules, derived from restriction fragments that have been cloned in vectors, that includes all or part of the genetic material of an organism. (On-line Medical Dictionary)
C15242	Health_Maintenance_Organization	Health_Care_Organization	Health Maintenance Organization|HMO	A managed care organization that provides health services to enrolled individuals.
C15243	Health_Promotion_Salutogenesis	Lifestyle_and_Disease_Prevention	Health Promotion (Salutogenesis)|Health Promotion|Salutogenesis	NIH: Subcategory of Lifestyle and Disease Prevention in CAM.  This sub-category deals with pre-clinical (laboratory and epidemiological) research on healing, the healing process, health promoting (salutogenic) factors and their interactions.  Observational studies on the interactive effects of diet, social support, stress management, and exercise in the promotion of health and prevention of morbidity and mortality are included here.
C15244	Access_to_Care	Health_Care_Delivery	Access to Care|Health Care Access	The degree to which individuals are inhibited or facilitated in their ability to gain entry to and to receive care and services from the health care system. Factors influencing this ability include geographic, architectural, transportational, and financial considerations, among others.
C15245	Health_Services_Research	Outcomes_and_Health_Services_Research	Health Services Research	The integration of epidemiologic, sociological, economic, and other analytic sciences in the study of health services. Health services research is usually concerned with relationships between need, demand, supply, use, and outcome of health services. The aim of the research is evaluation, particularly in terms of structure, process, output, and outcome. (From Last, Dictionary of Epidemiology, 2d ed)
C15246	Heart_Transplantation	Organ_Transplantation	Heart Transplantation|cardiac transplantation|heart grafting
C15247	Heart_and_Lung_transplantation	Organ_Transplantation	Heart and Lung Transplantation|Heart Lung Grafting|Heart Lung Transplantation|Heart-Lung Grafting|Heart-Lung Transplantation
C15248	Hemodialysis	Dialysis	Hemodialysis|HD|artificial kidney dialysis|extracorporeal dialysis|kidney dialysis|renal dialysis
C15249	Hepatectomy	Abdominal_Surgical_Procedures|Digestive_System_Surgery	Hepatectomy|hepatectomy	Surgery to remove all or part of the liver.
C15250	Phytotherapy_or_Herbalism	Biologically_Based_Therapy	Phytotherapy or Herbalism	NIH: Subcategory of Biological Based Therapies in CAM. This sub-category addresses plant-derived preparations used for therapeutic and preventive purposes.  Included are: Individual herbs - Ginkgo biloba, Hypericum, Garlic, Ginseng, Echinacea, Saw palmetto, Urtica diocia (nettle), Kava kava, Hawthorne, Witch Hazel, Bilberry, Ginger, Aloe vera, Capsicum, Feverfew, Green tea, Tee Tree oil, Licorice root, Yohimbe, Valerian, Bee Pollen, Cat's Claw, Evening Primrose, Dong Quai, Fenugreek, Marshmallow, Psyllium, Tumeric. Combinations include: Padma 28, Hoxey, Essiac, Saw palmetto, Pygeum africanum.
C15251	Postmenopausal_Hormone_Replacement_Therapy	Hormone_Replacement_Therapy	Postmenopausal Hormone Replacement Therapy
C15252	Hospice_Care	Palliative_Care	Hospice Care|End of Life Care|Hospice|hospice	(HOS-pis) A program that provides special care for people who are near the end of life and for their families, either at home, in freestanding facilities, or within hospitals.
C15253	Hospital_Administration	Healthcare_Activity	Hospital Administration|Hospital Administration / HMO|Hospital Management	Management of the internal organization of the hospital.
C15254	Human_Genome_Project	Basic_Science	Human Genome Project
C15255	Hypophysectomy	Head_and_Neck_Surgery	Hypophysectomy|Excision of the Hypophysis|Excision of the Pituitary Gland|Excision of the Pituitary Gland+B3297|Hypophysis Cerebri Excision|Hypophysis Excision|Pituitary Gland Excision|Pituitectomy	Surgical excision of the Hypophysis cerebri.  Often used in the treatment of metastatic bone pain, estrogen positive breast cancer, and prostate cancer pain. (Taber's)
C15256	Hysterectomy	Gynecological_Surgical_Procedure	Hysterectomy|hysterectomy	(hiss-ter-EK-toe-mee) An operation in which the uterus is removed.
C15257	Ileostomy	Colon_and_Rectal_Surgery|Ostomy	Ileostomy|ileostomy	(il-ee-AHS-toe-mee) An opening into the ileum, part of the small intestine, from the outside of the body. An ileostomy provides a new path for waste material to leave the body after part of the intestine has been removed.
C15258	Immunization	Primary_Prevention	Immunization|immunization	A technique used to cause an immune response that results in resistance to a specific disease, especially an infectious disease.
C15259	Passive_Immunization	Immunization	Passive Immunization|Adoptive Transfer	use of antibodies or primed lymphocytes from an immune donor to produce immunity against an antigenic substance or organism in a nonimmune host.
C15260	Immunodiagnosis	Diagnosis	Immunodiagnosis|Immunodiagnostics
C15261	Immunosuppressive_Therapy	Immunotherapy	Immunosuppressive Therapy|Anti-Rejection Therapy|Immunosuppression|immunosuppression|immunosuppressive therapy	Suppression of the body's immune system and its ability to fight infections or disease. Immunosuppression may be deliberately induced with drugs, as in preparation for bone marrow or other organ transplantation to prevent rejection of the donor tissue. It may also result from certain diseases such as AIDS or lymphoma or from anticancer drugs.
C15262	Immunotherapy	Biological_Therapy	Immunotherapy|ITX|Immunologically Directed Therapy|immunotherapy	(IM-yoo-no-THER-a-pee) Treatment to stimulate or restore the ability of the immune system to fight infections and other diseases. Also used to lessen side effects that may be caused by some cancer treatments.
C15263	in_vitro	Drug_Development_Experimental	in vitro	In the laboratory (outside the body). The opposite of in vivo (in the body).
C15264	Infant_Nutrition	Nutritional_Study	Infant Nutrition|Lactation / Infant Nutrition	Nutritional studies with a focus on the specific nutritional needs of children under the age of 2.
C15265	Kidney_Transplantation	Organ_Transplantation	Kidney Transplantation|kidney grafting|renal transplantation
C15266	Laparotomy	Abdominal_Surgical_Procedures	Laparotomy|laparotomy	(lap-a-RAH-toe-mee) A surgical incision made in the wall of the abdomen.
C15267	Laryngectomy	Head_and_Neck_Surgery	Laryngectomy|laryngectomy	(LAIR-in-JEK-tuh-mee) An operation to remove all or part of the larynx (voice box).
C15268	Laser_Surgery	Surgical_Procedure	Laser Surgery|Clinical, Surgery, Laser|conventional laser therapy	A type of operation using the cutting powers of laser beams from various sources. The use of a laser either to vaporize surface lesions or to make bloodless cuts in tissue. (from On-line Medical Dictionary)
C15269	Leukapheresis	Pheresis	Leukapheresis|Leukocytopheresis|Therapeutic Leukopheresis|leukapheresis	Removal of the blood to collect specific blood cells; the remaining blood is returned to the body.
C15270	Ligation	Surgical_Procedure	Ligation|Closure by Ligation|ligation	(lye-GAY-shun) The process of tying off blood vessels so that blood cannot flow to a part of the body or to a tumor.
C15271	Liver_Transplantation	Organ_Transplantation	Liver Transplantation|hepatic transplantation|liver grafting
C15272	Lobectomy	Excision	Lobectomy|lobectomy	(lo-BEK-toe-mee) The removal of a lobe.
C15273	Longitudinal_Study	Study_Design	Longitudinal Study|prospective	In medicine, a study or clinical trial in which participants are identified and then followed forward in time.
C15274	Lung_Transplantation	Organ_Transplantation	Lung Transplantation|lung grafting
C15275	Lymphadenectomy	Surgical_Procedure	Lymphadenectomy|excision of the lymph node|lymph node excision|lymphadenectomy	A surgical procedure in which the lymph nodes are removed and examined to see whether they contain cancer. For a regional lymph node dissection, some of the lymph nodes in the tumor area are removed; for a radical lymph node dissection, most or all of the lymph nodes in the tumor area are removed. Also called lymph node dissection.
C15276	Massage	Massage_and_Body_Techniques	Massage	A therapeutic method of manipulation, methodical pressure, friction, and kneading of the body. (from Taber's)
C15277	Mastectomy	Amputation|Breast_Cancer_Treatment	Mastectomy|Mammectomy|mastectomy	(mas-TEK-toe-mee) Surgery to remove the breast (or as much of the breast tissue as possible).
C15278	Modified_Radical_Mastectomy	Mastectomy	Modified Radical Mastectomy|Modified Mastectomy|modified radical mastectomy	(mas-TEK-toe-mee) Surgery for breast cancer in which the breast, some of the lymph nodes under the arm, the lining over the chest muscles, and sometimes part of the chest wall muscles are removed.
C15279	Radical_Mastectomy	Mastectomy	Radical Mastectomy|radical mastectomy	(RAD-ih-kal mas-TEK-toe-mee) Surgery for breast cancer in which the breast, chest muscles, and all of the lymph nodes under the arm are removed.  For many years, this was the operation most used, but it is used now only when the tumor has spread to the chest muscles.  Also called the Halsted radical mastectomy.
C15280	Breast_Conservation_Treatment	Breast_Cancer_Treatment	Breast Conservation Treatment|BCT|Breast-Conserving Surgery|breast-conserving surgery	An operation to remove the breast cancer but not the breast itself. Types of breast-conserving surgery include lumpectomy (removal of the lump), quadrantectomy (removal of one quarter of the breast), and segmental mastectomy (removal of the cancer as well as some of the breast tissue around the tumor and the lining over the chest muscles below the tumor).
C15281	Total_Mastectomy	Mastectomy	Total Mastectomy|Simple Mastectomy|simple mastectomy|total mastectomy	(mas-TEK-toe-mee) Removal of the breast.
C15282	Oriental_Medicine	Acupuncture_and_Oriental_Medicine	Oriental Medicine	Subcategory of Alternative Medical Systems in CAM. This systems of practice includes acupuncture, acupressure, herbal applications, massage, diet, and exercises. These practices, especially in the form of Traditional Chinese Medicine have a prominent position in the U.S. Included are: Acupuncture, Herbal formulas, Diet, QiGong, Tai chi, Massage, manipulation, Acupotomy - Fibrosis, Fibromylogic electroacupuncture used in China at Great Wall Hospital.
C15283	Naturopathy	Treatment	Naturopathy	A system of therapy based on preventative care, and on the use of heat, water, light, air, and massage as primary therapies for disease. Some naturopaths use no medications, either pharmaceutical or herbal. Some recommend herbal remedies only. A few who are licensed to prescribe may recommend pharmaceuticals in those cases where they feel their use is warranted. (MedicineNet.com)
C15284	Nephrectomy	Urologic_Surgical_Procedure	Nephrectomy|nephrectomy	(nef-REK-toe-mee) Surgery to remove a kidney. Radical nephrectomy removes the kidney, the adrenal gland, nearby lymph nodes, and other surrounding tissue. Simple nephrectomy removes only the kidney. Partial nephrectomy removes the tumor but not the entire kidney.
C15285	Nursing_Research	Clinical_Study	Nursing Research	Clinical research carried out by nurses.
C15286	Nutritional_Assessment	Healthcare_Activity	Nutritional Assessment|Dietary Assessment
C15287	Nutritional_Requirements	Diet_and_Nutrition	Nutritional Requirements	The protein, carbohydrates, fats and cofactors required to maintain a healthy body
C15288	Orchiectomy	Surgical_Castration	Orchiectomy|Male Gonadectomy|ORCHX|orchiectomy	(or-kee-EK-toe-mee) Surgery to remove one or both testicles.
C15289	Organ_Transplantation	Transplantation	Organ Transplantation|Clinical, Transplantation, Organ|Organ Transplants|organ grafting	Organ transplantation is the transfer of an organ (or part of one) from one body to another, for the purpose of replacing the recipient's damaged or failing organ with a working one from the donor. Donors can be living, or cadaveric (dead). (from Wikipedia)
C15290	Ostomy	Surgical_Procedure	Ostomy|ostomy|surgical construction of a stoma	(AHS-toe-mee) An operation to create an opening (a stoma) from an area inside the body to the outside.  Colostomy and urostomy are types of ostomies.
C15291	Oophorectomy	Gynecological_Surgical_Procedure|Ovarian_Ablation|Surgical_Castration	Oophorectomy|Female Castration|Ovariectomy|oophorectomy	(o-o-for-EK-toe-mee) Surgery to remove one or both ovaries.
C15292	Palliative_Care	Supportive_Care	Palliative Therapy|Comfort Care|Palliative Care|Palliative Treatment|Symptom Management|Symptoms Management|comfort care|palliative care|palliative therapy|symptom management	Care that prevents or relieves the symptoms of disease or the side effects of treatment. Palliative care does not alter the course of a disease but can improve the quality of life. It attempts to meet the physical, emotional, spiritual, and practical needs of patients by helping to relieve pain, depression, or other problems.
C15293	Pancreas_Transplantation	Organ_Transplantation	Pancreas Transplantation|pancreas grafting
C15294	Pancreatectomy	Abdominal_Surgical_Procedures|Digestive_System_Surgery	Pancreatectomy|Excision of the Pancreas|Pancreas Excision|pancreatectomy	(pan-kree-a-TEK-toe-mee) Surgery to remove all or part of the pancreas. In a total pancreatectomy, part of the stomach, part of the small intestine, the common bile duct, gallbladder, spleen, and nearby lymph nodes also are removed.
C15295	Perfusion	Regional_Chemotherapy	Perfusion|perfusion	Bathing an organ or tissue with a fluid. In regional perfusion, a specific area of the body (usually an arm or a leg) receives high doses of anticancer drugs through a blood vessel. Such a procedure is performed to treat cancer that has not spread.
C15296	Isolated_Perfusion	Perfusion	Isolated Perfusion|perfusion, isolated
C15297	Peritoneal_Dialysis	Dialysis	Peritoneal Dialysis
C15298	Intraperitoneal_Infusion	Retired_Concepts	Intraperitoneal Infusion|intraperitoneal infusion	A method of delivering fluids and drugs directly into the abdominal cavity through a thin tube.
C15299	Pharmacokinetics	Drug_Development	Pharmacokinetics|pharmacokinetics	The activity of drugs in the body over a period of time, including the processes by which drugs are absorbed, distributed in the body, localized in the tissues, and excreted.
C15300	Photodynamic_Therapy	Chemotherapy	Photodynamic Therapy|PDT|photodynamic therapy|therapy, photodynamic	(foe-toe-dye-NAM-ik) Treatment with drugs that become active when exposed to light.  These drugs kill cancer cells.
C15301	Phototherapy	Cancer_Treatment	Phototherapy	The treatment of a disorder by exposure to light, including ultraviolet and infrared radiation. (Bartleby.com)
C15302	Physical_Therapy	Treatment	Physical Therapy|PT|Physiatric Procedure|Physical Medicine Procedure|Physical Therapeutics|Physical Therapy Procedure|Physiotherapy|Physiotherapy Procedure|physical therapy	The use of exercises and physical activities to help condition muscles and restore strength and movement.  For example, physical therapy can be used to restore arm and shoulder movement and build back strength after breast cancer surgery.
C15303	Pilot_Study	Research	Pilot Study|pilot study	The initial study examining a new method or treatment.
C15304	Plasmapheresis	Pheresis	Plasmapheresis|Plasma Exchange|Therapeutic Plasma Exchange|Therapeutic Plasmapheresis|plasmapheresis	(plas-ma-fer-EE-sis) The process of separating certain cells from the plasma in the blood by a machine; only the cells are returned to the person. Plasmapheresis can be used to remove excess antibodies from the blood.
C15305	Pneumonectomy	Thoracic_Surgical_Procedures	Pneumonectomy|pneumonectomy	(noo-mo-NEK-toe-mee) An operation to remove an entire lung.
C15306	Primary_Prevention	Prevention	Primary Prevention|Prevention, Primary	Prevention of disease or mental disorders in susceptible individuals or populations through promotion of health, including mental health, and specific protection, as in immunization, as distinguished from the prevention of complications or after-effects of existing disease.
C15307	Prostatectomy	Urologic_Surgical_Procedure	Prostatectomy|PRSTMY|prostatectomy	(pros-ta-TEK-toe-mee) An operation to remove part or all of the prostate. Radical (or total) prostatectomy is the removal of the entire prostate and some of the tissue around it.
C15308	Psychotherapy	Treatment	Psychotherapy	A method of treating disease, esp. psychic disorders, by mental rather than pharmacological means (e.g., suggestion, re-education, hypnotism, and psychoanalysis). (Taber's)
C15309	Public_Health_Administration	Healthcare_Activity	Public Health Administration	Management of public health organizations or agencies.
C15310	Paracentesis	Aspiration	Paracentesis|paracentesis	Insertion of a thin needle or tube into the abdomen to remove fluid from the peritoneal cavity.
C15311	Quality_Control	Quality_Assurance	Quality Control
C15312	Radiation_Dosimetry	Healthcare_Activity	Radiation Dosimetry	The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by scintillation counting.
C15313	Radiation_Therapy	Cancer_Treatment	Radiation Therapy|Cancer Radiotherapy|Irradiation|RT|Radiotherapeutics|Radiotherapy|Therapy, Radiation|irradiation|radiation therapy|radiotherapy	(RAY-dee-AY-shun) The use of high-energy radiation from x-rays, gamma rays, neutrons, and other sources to kill cancer cells and shrink tumors. Radiation may come from a machine outside the body (external-beam radiation therapy) or from materials called radioisotopes. Radioisotopes produce radiation and can be placed in or near the tumor or in the area near cancer cells. This type of radiation treatment is called internal radiation therapy, implant radiation, interstitial radiation, or brachytherapy. Systemic radiation therapy uses a radioactive substance, such as a radiolabeled monoclonal antibody, that circulates throughout the body.
C15314	Diagnostic_Reagents_and_Test_Kits	Diagnostic_Methods_and_Reagents	Diagnostic Reagents and Test Kits	3C; Product Evaluation, Research, and Monitoring; Diagnostic Reagents and Test Kits (FMB)
C15315	Rehabilitation	Supportive_Care	Rehabilitation|Physical Health Services / Rehabilitation|Rehabilitation, Medical|rehabilitation therapy	Restoration of the ability to function in a normal or near normal manner following disease, illness, or injury.
C15316	Relaxation_Therapy	Mind-Body_Intervention	Relaxation Therapy	A therapeutic regimen in which the patient is guided by the therapist into alternate relaxation and flexing of muscles throughout the body as a method of pain control.  It is related to guided imagery and distraction and attention therapies.
C15317	Second-Look_Surgery	Surgical_Procedure	Second-Look Surgery|Reoperation|Repeat Surgery|SL|Second Look|second-look surgery|surgical revision	Surgery performed after cancer treatment to assess the results of prior treatment and to plan possible future treatment. (http://info.cancer.ca/e/glossary/S/Second-Look_Surgery.htm)
C15318	Reproducibility	Clinical_Testing	Reproducibility
C15319	Research	Clinical_or_Research_Activity	Research|RSCH|Study	Systematic investigation into a subject in order to discover facts, establish or revise a theory, or develop a plan of action based on the facts discovered.
C15320	Study_Design	Research_Activity	Study Design|Experiment Design|Experimental Design|Research Design|Study Type	A plan detailing how a study will be performed in order to represent the phenomenon under examination, to answer the research questions that have been asked, and defining the methods of data analysis. Study design is driven by research hypothesis being posed, study subject/population/sample available, logistics/resources: technology, support, networking, collaborative support, etc.
C15321	Research_Resources	NCI_Administrative_Concepts	Research Resources|Resources	The funding, research facilities, and materials available for research
C15322	Respiratory_Therapy	Rehabilitation	Respiratory Therapy|respiratory therapy	(RES-pih-ra-tor-ee) Exercises and treatments that help improve or restore lung function.
C15323	Salpingo-Oophorectomy	Gynecological_Surgical_Procedure|Ovarian_Ablation	Salpingo-Oophorectomy|salpingo-oophorectomy	(sal-PIN-go o-o-for-EK-toe-mee) Surgical removal of the fallopian tubes and ovaries.
C15324	Self_Care	Healthcare	Self Care	consumer (patients or their families or friends) performance of medical activities traditionally performed by professional health care providers; for daily self maintenance (dressing, hygiene, eating, etc.), use FUNCTIONAL ABILITY.
C15325	Skin_Transplantation	Organ_Transplantation	Skin Transplantation|dermatoplasty|skin grafting
C15326	Sperm_Banking	Supportive_Care	Sperm Banking|sperm banking	Freezing sperm for use in the future. This procedure can allow men to father children after loss of fertility.
C15327	Lumbar_Puncture	Aspiration	Lumbar Puncture|LP|Spinal Tap|lumbar puncture|spinal tap	A procedure in which a needle is put into the lower part of the spinal column to collect cerebrospinal fluid or to give anticancer drugs intrathecally.
C15328	Splenectomy	Abdominal_Surgical_Procedures	Splenectomy|SPLNOTM|splenectomy	(splen-EK-toe-mee) An operation to remove the spleen.
C15329	Surgical_Procedure	Procedure	Surgical Procedure|SX|Surgery|Surgical Interventions|Surgical Procedures|surgery	(SERJ-uh-ree) A procedure to remove or repair a part of the body or to find out whether disease is present.  An operation.
C15330	Digestive_System_Surgery	Surgical_Procedure	Digestive System Surgery|Surgery, Digestive System|Surgery, Gastrointestinal|digestive system operative procedure|digestive system surgical procedure|gastrointestinal surgical procedure|gastrointestinal system operative procedure|operative procedure on the digestive system|operative procedure on the gastrointestinal system	Surgery performed on any part of the digestive system.
C15331	Ophthalmologic_Surgical_Procedure	Surgical_Procedure	Ophthalmologic Surgical Procedure|Surgery, Ophthalmological|eye surgery|ophthalmological surgical procedure	Surgery involving the eyes
C15332	Gynecological_Surgical_Procedure	Urogenital_Surgical_Procedure	Gynecological Surgical Procedure|gynecologic surgery|gynecologic surgical procedures|gynecological surgery
C15333	Urogenital_Surgical_Procedure	Abdominal_Surgical_Procedures	Urogenital Surgical Procedure|Surgery, Genitourinary|Urogenital Surgery	Any surgery to the urinary system or its parts.
C15334	Urologic_Surgical_Procedure	Abdominal_Surgical_Procedures	Urologic Surgical Procedure|Urinary Tract Surgery|Urologic Surgery|Urological Surgical Procedure
C15335	Technology_Assessment	Research_Activity	Technology Assessment	Technology assessment (TA) arose in the mid-1960s from an appreciation of the critical role of technology in modern society and its potential for unintended, and sometimes harmful, consequences. TA was conceived as a way to identify the desirable first-order, intended effects of technologies as well as the higher-order, unintended social, economic and environmental effects.  TA methodology draws upon a variety of analytical, evaluative and planning techniques. Among these are systems analysis, cost-benefit analysis, consensus methods (e.g., Delphi method), engineering feasibility studies, clinical trials, market research, technological forecasting, and others. TA practitioners and policy makers recognized that TA is evolving, flexible, and should be tailored to the task (Brooks and Bowers 1970 and U.S. Congress, Office of Technology Assessment 1977).
C15336	Testing	Research_Activity	Testing	A procedure for critical evaluation.
C15337	Thoracotomy	Thoracic_Surgical_Procedures	Thoracotomy|TROTMY|incision of chest wall|incision of thorax|thoracotomy	(thor-a-KAH-toe-mee) An operation to open the chest.
C15338	Thrombolytic_Therapy	Infusion	Thrombolytic Therapy|fibrinolytic therapy
C15339	Tissue_Collection	Repository_of_Specimens_and_Reagents	Tissue Collection|Tissue Bank|Tissue/Specimen Collection	A repository of the tissue specimen, cells or cell lines, for experimental purpose. It can be from different diseases or different parts of the body.
C15340	Total_Pancreatectomy	Pancreatectomy	Total Pancreatectomy|Total Excision of the Pancreas|total pancreatectomy	Surgery to remove the entire pancreas. Part of the stomach, part of the small intestine, the common bile duct, gallbladder, spleen, and nearby lymph nodes also are removed.
C15341	Tracheostomy	Head_and_Neck_Surgery|Ostomy	Tracheostomy|Tracheostomy Procedure|tracheostomy	(TRAY-kee-AHS-toe-mee) Surgery to create an opening (stoma) into the windpipe. The opening itself may also be called a tracheostomy.
C15342	Transplantation	Surgical_Procedure	Transplantation|Grafting Procedure|Surgery, Transplantation|Transplantation Surgery|transplantation	The grafting of tissues from one individual to another or place to place within a single individual.
C15343	Transurethral_Prostatic_Resection	Prostatectomy|Transurethral_Resection	Transurethral Prostatic Resection|TURP|Transurethral Prostatectomy|prostate transurethral resection|transurethral resection of the prostate	(TRANZ-yoo-REE-thral ree-SEK-shun) Surgical procedure to remove tissue from the prostate using an instrument inserted through the urethra.
C15344	UV_Light_Therapy	Phototherapy	UV Light Therapy|Light Therapy, UV|Therapy, UV Light|Ultraviolet Radiation Therapy|ultraviolet radiation therapy	A form of radiation used in the treatment of cancer.
C15345	Ureterostomy	Urostomy	Ureterostomy
C15346	Vaccination	Active_Immunization	Vaccination|VAC|vaccination	Administration of vaccines to stimulate the host's immune response. This includes any preparation intended for active immunological prophylaxis or treatment.
C15347	Vaccine_Therapy	Immunotherapy	Vaccine Therapy|VAC-TX	Active immunization where vaccine is administered for therapeutic or preventive purposes. This can include administration of immunopotentiating agents such as BCG vaccine and Corynebacterium parvum as well as biological response modifiers such as interferons, interleukins, and colony-stimulating factors in order to directly stimulate the immune system.
C15348	Vasectomy	Urogenital_Surgical_Procedure	Vasectomy|vasectomy	(vas-EK-toe-mee) An operation to cut or tie off the two tubes that carry sperm out of the testicles.
C15349	Nutrition_Water	Nutrition_Dietary_Components	Nutrition, Water	Role of water in cancer causation or prevention and in general health.
C15350	Total-Body_Irradiation	Bone_Marrow_Ablation|Extensive_Radiation|Prior_Extensive_Radiation	Total-Body Irradiation|Total Body Irradiation|Whole-Body Irradiation|total-body irradiation	Radiation therapy to the entire body. Usually followed by bone marrow or peripheral stem cell transplantation.
C15351	Adoptive_Immunotherapy	Biological_Immunotherapy|Passive_Immunization	Adoptive Immunotherapy|Adoptive Cell Immunotherapy|adoptive cellular immunotherapy	A technique for enhancing cell-mediated immunity by either artificially increasing the number of specific immunocompetent cells through inoculation of ex-vivo expanded primarily activated cytotoxic lymphocytes, or genetically engineered lymphocytes with enhanced cytotoxic ability, or by altering tumor cells to make them more immunogenic. The concept does not refer to anticancer vaccines and immune modulation through the therapeutic use of cytokines, cell receptors, or other substances
C15352	Pancreatic_Islet_Transplantation	Organ_Transplantation	Pancreatic Islet Transplantation|islets of Langerhans transplantation
C15353	Self-Examination	Self_Care	Self-Examination|Self-Surveillance	inspection of one's own body, usually for signs of disease.
C15354	Breast_Reconstruction	Surgical_Procedure	Breast Reconstruction|Mammaplasty|breast reconstruction	Surgery to rebuild a breast's shape after a mastectomy.
C15355	Radioimmunotherapy	Cancer_Immunotherapy|Radiation_Therapy	Radioimmunotherapy|Immunoradiotherapy|Immunotherapy, Cancer, Radioisotope|radioimmunotherapy	Treatment with a radioactive substance that is linked to an antibody so that it will attach to a tumor when injected into the body.
C15356	Whipple_procedure	Abdominal_Surgical_Procedures|Digestive_System_Surgery	Whipple procedure	A type of surgery used to treat pancreatic cancer. The head of the pancreas, the duodenum, a portion of the stomach, and other nearby tissues are removed.
C15357	Esophagectomy	Head_and_Neck_Surgery	Esophagectomy|esophagectomy|excision of the esophagus	(eh-sof-a-JEK-toe-mee) An operation to remove a portion of the esophagus.
C15358	Stereotaxic_Radiosurgery	Radiation_Surgery	Stereotaxic Radiosurgery|Stereotactic Radiosurgery|stereotactic radiosurgery|stereotaxic radiosurgery	(STAIR-ee-o-TAK-tik...) A radiation therapy technique involving a rigid head frame that is attached to the skull; high-dose radiation is administered through openings in the head frame to the tumor while decreasing the amount of radiation given to normal brain tissue. This procedure does not involve surgery.
C15359	Salvage_Therapy	Cancer_Treatment	Salvage Therapy|SALVAGE-TX|salvage therapy	Treatment that is given after the cancer has not responded to other treatments.
C15360	Adjuvant_Chemotherapy	Adjuvant_Therapy	Adjuvant Chemotherapy
C15361	Fine-Needle_Aspiration	Needle_Biopsy	Fine-Needle Aspiration|Aspirate, Fine Needle|FNA|Fine Needle Aspiration|fine-needle aspiration	The removal of tissue or fluid with a needle for examination under a microscope. Also called needle biopsy.
C15362	Case_Study	Study_Design	Case Study|Case Report|case report	A detailed report of the diagnosis, treatment, and follow-up of an individual patient. Case reports also contain some demographic information about the patient (for example, age, gender, ethnic origin).
C15363	Healthcare	Clinical_Services	Healthcare	heading term for medical terms other than physician specialties; for organizations and facilities, see BIOMEDICAL RESOURCE.
C15364	Managed_Care	Healthcare	Managed Care	An arrangement whereby a third-party payer (e.g., insurance company, federal government, or corporation) mediates between physicians and patients, negotiating fees for service and overseeing the types of treatment given.  Managed care has virtually replaced unmanaged indemnity plans, where payment is automatic and oversight procedures are minimal.  Whereas 96% of American workers had unmanaged indemnity in 1984, only 28% did in 1988.  Typically, in managed care, the third-party payer requires second opinions and pre-certification review for patients requiring hospital admission.  They obtain wholesale prices from doctors, and carry out cost-containment measures, including auditing hospitals and reviewing claims.  Managed care has figured heavily in the national debate over health care.
C15365	Outcomes_Research	Outcomes_and_Health_Services_Research	Outcomes Research	research aimed at assessing the quality and effectiveness of health care as measured by the attainment of a specified end result or outcome; for complete retrieval include RTs.
C15366	Platelet_Transfusion	Transfusion	Platelet Transfusion|Blood Platelet Transfusion|Plts
C15367	Risk_Assessment	Healthcare_Activity	Risk Assessment	The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences.
C15368	Treatment	Intervention	Treatment|TX|Therapeutic Interventions|Therapeutic Procedure|Therapies|Therapy|therapy	An action or administration of therapeutic agents to produce an effect that is intended to alter the course of a pathologic process.
C15369	Allogeneic_Bone_Marrow_Transplantation	Bone_Marrow_Transplantation	Allogeneic Bone Marrow Transplantation|Allo BMT|Allogeneic BMT|allogeneic bone marrow transplantation	(AL-o-jen-AY-ik) A procedure in which a person receives stem cells, the cells from which all blood cells develop, from a compatible, though not genetically identical, donor.
C15370	Steroid_Therapy	Biological_Therapy	Steroid Therapy|steroid therapy	Treatment with corticosteroid drugs to reduce swelling, pain, and other symptoms of inflammation.
C15371	Cerebral_Edema_Management	Supportive_Care	Cerebral Edema Management|management of cerebral edema
C15372	Smoking_Cessation_Intervention	Behavioral_Intervention	Smoking Cessation Intervention|Smoking and Tobacco Use Cessation Interventions
C15373	Therapeutic_Touch	Biofield_Therapy	Therapeutic Touch|Healing Touch	An alternative medical practice.  a consciously-directed process of energy exchange during which the practitioner uses the hands as a focus to stimulate and enhance the patient's own natural healing ability. (from Skeptic's Dictionary)
C15374	Douche	Procedure	Douche|douche	(DOOSH) A procedure in which water or a medicated solution is used to clean the vagina and cervix.
C15375	Imagery	Mind-Body_Intervention	Imagery|Guided Imagery|imagery	A technique in which the person focuses on positive images in his or her mind.
C15376	Transcendental_Meditation	Mind-Body_Intervention	Transcendental Meditation|TM|transcendental meditation	TM.  A mental technique used to promote relaxation, reduce stress, and improve quality of life.
C15377	Immunologic_Desensitization	Immunotherapy	Immunologic Desensitization|Desensitization|Desensitization, Immunologic|Hyposensitization Therapy	Treatment or therapy to reduce or eliminate a patient's allergic response to an allergen (NCI/OSP)
C15378	Boron_Neutron_Capture_Therapy	Local_Therapy|Radiation_Therapy	Boron Neutron Capture Therapy|boron neutron capture therapy	A type of radiation therapy. The person is given an intravenous infusion containing the element boron, which concentrates in the tumor cells. The person then receives radiation therapy with atomic particles called neutrons from a small research nuclear reactor. The radiation is absorbed by the boron, killing the tumor cells without harming normal cells.
C15379	Teleradiology	Telemedicine	Teleradiology	The electronic transmission of radiological images from one location to another for the purposes of interpretation and/or consultation. Users in different locations may simultaneously view images with greater access to secondary consultations and improved continuing education. (From American College of Radiology, ACR Standard for Teleradiology, 1994, p3)
C15380	Telemedicine	Health_Care_Delivery	Telemedicine	The use of telecommunications technology to provide, enhance, or expedite health care services, as by accessing off-site databases, linking clinics or physicians' offices to central hospitals, or transmitting x-rays or other diagnostic images for examination at another site. (Bartleby.com)
C15381	Quality_Assurance	Healthcare_Activity	Quality Assurance|QA	All actions taken to ensure that standards and procedures are adhered to and that delivered products or services meet performance requirements.
C15382	Gamma_Knife	Radiation_Surgery	Gamma Knife|Gamma Knife Radiosurgery|gamma knife	Radiation therapy in which high-energy rays are aimed at a tumor from many angles in a single treatment session.
C15383	Special_Diet_Therapy	Biologically_Based_Therapy	Special Diet Therapy	NIH: Subcategory of Biological Based Therapies in CAM. This sub-category deals with dietary approaches and special diets applied as alternative therapies for chronic disease in general or risk factors.  Examples include, Gerson, Wigmore, Atkins, Pritikin, McDougall, Paleolithic, Natural Hygiene, fasting, and folk and cultural foods, such as soy-based feeding, etc.  Included are: Pritikin, Ornish, McDougall, Gerson, Kelly-Gonzales, Wigmore, Livingston-Wheeler, Atkins, Diamond, Vegetarian, Fasting, High Fiber, Macrobiotic, Mediterranean, Paleolithic, Asian, Natural Hygiene.
C15384	Surgical_Incision	Conventional_Surgery	Surgical Incision|Incision|Otomy|incision	(in-SIH-zhun) A cut made in the body to perform surgery.
C15385	Excisional_Biopsy	Biopsy|Excision	Excisional Biopsy|excisional biopsy	(ek-SI-zhun-al BY-op-see) A surgical procedure in which an entire lump or suspicious area is removed for diagnosis. The tissue is then examined under a microscope.
C15386	Incisional_Biopsy	Biopsy	Incisional Biopsy|Open Biopsy|incisional biopsy	(in-SI-zhun-al BY-op-see) A surgical procedure in which a portion of a lump or suspicious area is removed for diagnosis. The tissue is then examined under a microscope.
C15387	Shave_Biopsy	Biopsy	Shave Biopsy|shave biopsy	(BY-ahp-see) A procedure in which the parts of a mole that are above and just below the surface of the skin are removed with a small blade. There is no need for stitches with this procedure.
C15388	Infusion	Treatment	Infusion|INF|infusion	A method of putting fluids, including drugs, into the bloodstream. Also called intravenous infusion.
C15389	Endoscopic_Biopsy	Biopsy	Endoscopic Biopsy
C15390	Fulguration	Surgical_Procedure	Fulguration|fulguration	(ful-gyoor-AY-shun) Destroying tissue using an electric current.
C15391	Electrodesiccation	Fulguration|Local_Therapy	Electrodesiccation|electrodesiccation	(e-LEK-tro-des-ih-KAY-shun) The drying of tissue by a high-frequency electric current applied with a needle-shaped electrode.
C15392	Thoracentesis	Paracentesis|Thoracic_Surgical_Procedures	Thoracentesis|Chest Aspiration|Pleural Cavity Tap|Pleural Tap|Pleurocentesis|Puncture of Pleural Cavity for Aspiration|Thoracic Paracentesis|thoracentesis	(thor-a-sen-TEE-sis) Removal of fluid from the pleural cavity through a needle inserted between the ribs.
C15393	Limb_Perfusion	Isolated_Perfusion	Limb Perfusion|ILP|Isolated Limb Perfusion|isolated limb perfusion|limb perfusion	(per-FYOO-zhun) A technique that may be used to deliver anticancer drugs directly to an arm or leg. The flow of blood to and from the limb is temporarily stopped with a tourniquet, and anticancer drugs are put directly into the blood of the limb. This allows the person to receive a high dose of drugs in the area where the cancer occurred.  Also called isolated limb perfusion.
C15394	Partial_Hepatectomy	Excision|Hepatectomy	Partial Hepatectomy|partial excision of liver|subtotal hepatectomy	Partial removal of the liver
C15395	Autologous_Bone_Marrow_Transplantation	Bone_Marrow_Transplantation	Autologous Bone Marrow Transplantation|ABMT|Autologous Bone Marrow Transplant|Autologous Marrow Transplantation|autologous bone marrow transplantation	(aw-TAHL-o-gus) A procedure in which bone marrow is removed from a person, stored, and then given back to the person after intensive treatment.
C15396	Radical_Cystectomy	Cystectomy	Radical Cystectomy|radical cystectomy	(RAD-ih-kal sis-TEK-toe-mee) Surgery to remove the bladder as well as nearby tissues and organs.
C15397	Bladder_Irrigation	Treatment	Bladder Irrigation|irrigation of urinary bladder|simple bladder irrigation	Instillation of a solution into the bladder to provide cleansing or medication. (NIC96)
C15398	Urethrostomy	Urostomy	Urethrostomy
C15399	Radical_Prostatectomy	Prostatectomy	Radical Prostatectomy|Prostatovesiculectomy|radical prostatectomy	(RAD-ih-kal pros-ta-TEK-toe-mee) Surgery to remove the entire prostate. The two types of radical prostatectomy are retropubic prostatectomy and perineal prostatectomy.
C15400	Perineal_Prostatectomy	Prostatectomy	Perineal Prostatectomy|perineal prostatectomy	(peh-rih-NEE-al pros-ta-TEK-toe-mee) Surgery to remove the prostate through an incision made between the scrotum and the anus.
C15401	Retropubic_Prostatectomy	Prostatectomy	Retropubic Prostatectomy|retropubic prostatectomy	(re-tro-PYOO-bik pros-ta-TEK-toe-mee) Surgery to remove the prostate through an incision made in the abdominal wall.
C15402	Conization	Biopsy	Conization|Cone Biopsy of Cervix|Conization of Cervix|Conization of Uterine Cervix|cone biopsy|conization	(ko-nih-ZAY-shun) Surgery to remove a cone-shaped piece of tissue from the cervix and cervical canal. Conization may be used to diagnose or treat a cervical condition.
C15403	Endocervical_Curettage	Curettage_Procedure	Endocervical Curettage|endocervical curettage	(en-do-SER-vih-kul kyoo-reh-TAHZH) The scraping of the mucous membrane of the cervical canal using a spoon-shaped instrument called a curette.
C15404	Mediastinotomy	Surgical_Incision|Thoracotomy	Mediastinotomy|incision of the mediastinum
C15405	Prevention	Intervention	Prevention|Prevention Measures|Prophylaxis|prophylaxis	An attempt to prevent disease.
C15406	Cancer_Screening	Screening	Cancer Screening|Cancer Screening for Patients|Screening of Cancer|cancer detection, early|early cancer detection	The use of any device, marker, or other means for the purpose of detecting the presence of a tumor, usually before there are any symptoms.
C15407	Family_Study	Population_Study	Family Study
C15408	Transfusion	Blood_Treatment|Infusion	Transfusion|TRNSF|transfusion	(trans-FYOO-zhun) The infusion of components of blood or whole blood into the bloodstream. The blood may be donated from another person, or it may have been taken from the person earlier and stored until needed.
C15409	Packed_Red_Blood_Cell_Transfusion	Transfusion	Packed Red Blood Cell Transfusion|PRBC|PRBC Transfusion|Packed Red Blood Cells Transfusion
C15410	Biological_Response_Modifier_Therapy	Retired_Concepts	Biological Response Modifier Therapy|Biological Response Modifiers Therapy	(by-o-LAHJ-i-kul...) BRM. Treatment to stimulate or restore the ability of the immune system to fight infections and other diseases. Also used to lessen side effects that may be caused by some cancer treatments. Also known as biological therapy, immunotherapy, or biotherapy.
C15411	Cytokine_Therapy	Immunotherapy	Cytokine Therapy
C15412	Lymphokine-Activated_Killer_Cell_Therapy	Adoptive_Immunotherapy	Lymphokine-Activated Killer Cell Therapy|LAK cell therapy
C15413	Fertility_Study	Population_Research	Fertility Study
C15414	ADCC_Assay	Cellular_Assay	ADCC Assay	An assay based on Antibody-Dependent Cellular Cytotoxicity which involves the killing of a target cell by a killer cell by means of an antibody directed to the target by the antigen-binding arms and anchored to the killer cell via an Fc receptor.
C15415	Hyperthermia_Treatment	Biological_Therapy	Hyperthermia Treatment|Clinical Hyperthermia|Diathermy|Hyperthermia|diathermy|hyperthermia	(hye-per-THER-mee-a) A type of treatment in which body tissue is exposed to high temperatures to damage and kill cancer cells or to make cancer cells more sensitive to the effects of radiation and certain anticancer drugs.
C15416	Active_Immunization	Immunization	Active Immunization	immunity that results from the response of the immune system to an injection of antigen into an animal.
C15417	Randomized_Clinical_Trial	Clinical_Trial	Randomized Clinical Trial|Randomized Clinical Trials|randomized clinical trial	A study in which the participants are assigned by chance to separate groups that compare different treatments; neither the researchers nor the participants can choose which group.  Using chance to assign people to groups means that the groups will be similar and that the treatments they receive can be compared objectively.  At the time of the trial, it is not known which treatment is best. It is the patient's choice to be in a randomized trial.
C15418	Sargramostim_Thiotepa	Chemotherapy_Regimen	Sargramostim/Thiotepa|GM-CSF/TSPA
C15419	Screening	Intervention	Disease Screening|Disease Screening Procedure	Checking for disease when there may be no symptoms the individual being screened is aware of.
C15420	Hypnotherapy	Mind-Body_Intervention	Hypnotherapy	Therapeutic use of hypnotism.  It has been used to treat phobias and anxiety, to manage pain, and to extinguish habits and addictions. (Taber's)
C15421	Postmenopausal	Menopausal_Status	Postmenopausal|postmenopausal	Refers to the time after menopause. Menopause is the time in a woman's life when menstrual periods stop permanently; also called "change of life."
C15422	Human_Migration	Population_Study	Human Migration|Human Migration / Distribution	Movement of residence from one place to another. Includes nomadism; labor or seasonal migration; patterns of rural, urban, or suburban migration; or voluntary or forced relocation. (PSY94)
C15423	Psychosocial_Rehabilitation	Psychosocial_Assessment_and_Care|Rehabilitation	Psychosocial Rehabilitation	Programs, techniques, or processes of treatment by which individuals acquire psychological and social skills and attitudes which facilitate community interaction.  (from PSY94)
C15424	Record_Linkage_Study	Population_Study	Record Linkage Study|Data Linkage	A study in which data from different sources are "linked".  Usually used to compile epidemiological data.  The logic of record linkage is that two or more items of information about a person recorded at different times, and perhaps in different places, may be of greater value when considered together than when either is considered alone.
C15425	Supplementation	Nutritional_Support	Supplementation|supplementation	Adding nutrients to the diet.
C15426	Database	Information_Resources	Database|DB|Data Bank|Database, Electronic	A database is an information set with a regular structure.  Although it can be applied to any set of information the term was invented to refer to computerised data, and is used almost exclusively in computing. (from Wikipedia)
C15427	Lymph_Node_Dissection	Dissection	Lymph Node Dissection|lymph node dissection	(limf node dis-EK-shun) A surgical procedure in which lymph nodes are removed and examined to see whether they contain cancer. Also called lymphadenectomy.
C15428	Interdisciplinary_Research	Research	Interdisciplinary Research|Interdisciplinary Studies|Multidisciplinary|Multidisciplinary Collaboration|Multidisciplinary Research	Studies that bring together multiple scientific disciplines to address specific issues.
C15429	Research_Activity	Clinical_or_Research_Activity	Research Activity
C15430	Peripheral_Blood_Stem_Cell_Transplantation	Stem_Cell_Transplantation	Peripheral Blood Stem Cell Transplantation|PBPC transplantation|Peripheral Blood Progenitor Cell Transplantation|Peripheral Stem Cell Support|Peripheral Stem Cell Transplantation|peripheral stem cell support|peripheral stem cell transplantation	(per-IF-er-al) A method of replacing blood-forming cells destroyed by cancer treatment. Immature blood cells (stem cells) in the circulating blood that are similar to those in the bone marrow are given after treatment to help the bone marrow recover and continue producing healthy blood cells. Transplantation may be autologous (an individual's own blood cells saved earlier), allogeneic (blood cells donated by someone else), or syngeneic (blood cells donated by an identical twin).
C15431	Stem_Cell_Transplantation	Transplantation	Stem Cell Transplantation|Hematopoietic Stem Cell Transplantation|stem cell transplantation	A method of replacing immature blood-forming cells that were destroyed by cancer treatment. The stem cells are given to the person after treatment to help the bone marrow recover and continue producing healthy blood cells.
C15432	Surveillance_Epidemiology_and_End_Results_Program	Cancer_Surveillance_Project	Surveillance, Epidemiology, and End Results Program|SEER|SEER-Surveillance, Epidemiology, and End Results|Surveillance, Epidemiology, and End Results Program (SEER)
C15433	Nutritional_Support	Supportive_Care	Nutritional Support|nutrition therapy|nutritional care|nutritional therapy
C15434	Technology_Transfer	Technology_Development	Technology Transfer	The process of converting scientific findings from research laboratories into useful products by the commercial sector. (On-line Medical Dictionary)
C15435	Transfer_Factor_Therapy	Passive_Immunization	Transfer Factor Therapy|therapy, transfer factor
C15436	Mind-Body_Intervention	Treatment	Mind-Body Intervention|Mind-Body Medicine|Mind-Body Medicine (with OBSSR)	NIH: Major category of larger classification Complementary and Alternative Medicine.  This category deals with behavioral, psychological, social and spiritual approaches to medicine not commonly used or accepted.  See also -- Mind-Body Systems; Mind-Body Methods; Religion and Spirituality; Social and contextual areas.
C15437	Nutrition_Food_and_Water_Contaminants	Nutrition_Dietary_Components	Nutrition, Food and Water Contaminants	Role of food and water contaminants in cancer causation or prevention and in general health.
C15438	Cancer_Immunotherapy	Chemotherapy|Immunotherapy	Cancer Immunotherapy|Immuno-Chemotherapy|Immunotherapy, Cancer, General|immunotherapy for cancer	Use of techniques, biologically active substances, and procedures to enhance or restore the ability of the host immune system to fight cancer. Also used to lessen adverse effects that may be caused by some cancer treatments.
C15439	PDQ_Information_System	Information_Resources	PDQ Information System|PDQ	Physician Data Query.  PDQ is an online database developed and maintained by the National Cancer Institute.  Designed to make the most current, credible, and accurate cancer information available to health professionals and the public, PDQ contains peer-reviewed summaries on cancer treatment, screening, prevention, genetics, and supportive care; a registry of cancer clinical trials from around the world; and directories of physicians, professionals who provide genetics services, and organizations that provide cancer care. Most of this information is available on the Cancer.gov Web site.  More specific information about PDQ can be found at http://cancer.gov/cancer_information/pdq/.
C15440	High-LET_Neutron_Therapy	Radiotherapy_High_Linear_Energy_Transfer	High-LET Neutron Therapy|neutron therapy|therapy, high-LET neutron|therapy, neutron
C15441	Interleukin-2_Poly-ICLC	Chemotherapy_Regimen	Interleukin-2/Poly ICLC|IL-2/Poly ICLC
C15442	Interleukin-2_Zidovudine	Chemotherapy_Regimen	Interleukin-2/Zidovudine|IL-2/ZDV
C15443	Low-LET_Cobalt-60_Gamma_Ray_Therapy	Radiotherapy_Low_Linear_Energy_Transfer	Low-LET Cobalt-60 Gamma Ray Therapy|therapy, low-LET cobalt-60 gamma ray
C15444	Low-LET_Photon_Therapy	Radiotherapy_Low_Linear_Energy_Transfer	Low-LET Photon Therapy|therapy, low-LET photon
C15445	Hormone_Therapy	Biological_Therapy	Hormone Therapy|Endocrine Therapy|HORMONAL-TX|Hormonal Therapy|endocrine therapy|hormonal therapy|hormone therapy	Treatment that adds, blocks, or removes hormones.  For certain conditions (such as diabetes or menopause), hormones are given to adjust low hormone levels.  To slow or stop the growth of certain cancers (such as prostate and breast cancer), hormones may be given to block the body's natural hormones.  Sometimes surgery is needed to remove the source of hormones.
C15446	Adjuvant_Study	Clinical_Trial	Adjuvant Study|Adjuvant Protocol|Adjuvant Trial|Adjuvant Trials
C15447	Dietary_Intervention	Intervention	Dietary Intervention|Nutrition Interventions|Nutritional Interventions|intervention, dietary
C15448	Graft_Versus_Host_Disease_Prophylaxis_Therapy	Immunotherapy	Graft Versus Host Disease Prophylaxis/Therapy|GVHD prophylaxis/therapy
C15449	Somatostatin_Analog_Therapy	Hormone_Therapy	Somatostatin Analog Therapy|Somatostatin Analogue Therapy
C15450	Prior_Chemotherapy_for_Advanced_Disease	Prior_Chemotherapy	Prior Chemotherapy for Advanced Disease
C15451	Prior_Anthracycline_Therapy	Prior_Therapy	Prior Anthracycline Therapy|Prior Anthracycline|Prior Anthracycline Usage
C15452	Prior_Biologic_Therapy	Prior_Therapy	Prior Biologic Therapy
C15453	Prior_Interferon_Therapy	Prior_Biologic_Therapy	Prior Interferon Therapy
C15454	Head_and_Neck_Surgery	Surgical_Procedure	Head and Neck Surgery
C15455	Evaluation_of_Cancer_Risk_Factors	Evaluation_of_Risk_Factors	Evaluation of Cancer Risk Factors|cancer risk factors evaluation
C15456	Low-LET_Implant_Therapy	Radiotherapy_Low_Linear_Energy_Transfer	Low-LET Implant Therapy|therapy, low-LET implant
C15457	Low-LET_Electron_Therapy	Radiotherapy_Low_Linear_Energy_Transfer	Low-LET Electron Therapy|therapy, low-LET electron
C15458	High-LET_Heavy_Ion_Therapy	Radiotherapy_High_Linear_Energy_Transfer	High-LET Heavy Ion Therapy|Heavy Ion Radiation|Therapy, High-LET Heavy Ion
C15459	High-LET_Pion_Therapy	Radiotherapy_High_Linear_Energy_Transfer	High-LET Pion Therapy|therapy, high-LET pion
C15460	Mixed_High-Low_LET_Therapy	Local_Therapy|Radiation_Therapy	Mixed High-Low LET Therapy|therapy, mixed high-low LET
C15461	Non-Specific_Immune-Modulator_Therapy	Immunotherapy	Non-Specific Immune-Modulator Therapy
C15462	in_vitro-Treated_Bone_Marrow_Transplantation	Bone_Marrow_Transplantation	in vitro-Treated Bone Marrow Transplantation|antibody treated bone marrow transplant|antibody treated bone marrow transplantation|in vitro-treated bone marrow transplant|monoclonal antibody treated bone marrow transplant|monoclonal antibody treated bone marrow transplantation
C15463	Chemosensitization	Immune_Response	Chemosensitization|Chemosensitization/Potentiation|Potentiation	The synergistic action of two drugs, being greater than the sum of the effects of each used alone.(Online Medical Dictionary)
C15464	Radiosensitization	Chemotherapy	Radiosensitization|radiosensitization	The use of a drug that makes tumor cells more sensitive to radiation therapy.
C15465	Syngeneic_Bone_Marrow_Transplantation	Bone_Marrow_Transplantation	Syngeneic Bone Marrow Transplantation	Bone marrow transplantation in which the donor and recipient are genetically identical.
C15466	Laser_Therapy	Phototherapy	Laser Therapy|Therapy, Laser|laser therapy	The use of an intensely powerful beam of light to kill cancer cells.
C15467	Ablative_Endocrine_Surgery	Surgical_Procedure	Ablative Endocrine Surgery
C15468	Depigmentation_Therapy	Supportive_Care	Depigmentation Therapy
C15469	Interferon_Therapy	Immunotherapy	Interferon Therapy
C15470	Isotope_Therapy	Radiation_Therapy	Isotope Therapy|Radioactive Isotope Therapy|therapy, isotope, radioactive
C15471	Replacement_Therapy	Biological_Therapy	Replacement Therapy	Administration of a body substance to compensate for the loss, as from disease or surgery, of a gland or tissue that would normally produce the substance.
C15472	Adrenal_Blockade	Hormone_Therapy	Adrenal Blockade	Treatment to block production of adrenal hormones.
C15473	Nausea_and_Vomiting_Therapy	Palliative_Other_Than_Pain_and_Hospice	Nausea and Vomiting Therapy|antiemetic support|management of nausea and vomiting|nausea and vomiting management|vomiting and nausea management
C15474	Hematologic_Toxicity_Attenuation	Toxicity_Attenuation	Hematologic Toxicity Attenuation|neutropenia attenuation
C15475	Radioprotection	Treatment	Radioprotection
C15476	Complications_of_Therapy_Assessment	Supportive_Care	Complications of Therapy Assessment|assessment of complications of therapy
C15477	Prior_Radiation_Therapy	Prior_Therapy	Prior Radiation Therapy|Prior RT|Prior Radiotherapy
C15478	Group_C_Treatment_IND_Protocol	Protocol_Generic_Term	Group C/Treatment IND Protocol|Treatment IND Protocol, Group C	A means for providing compassionate use of investigational agents between the time that an agent has been shown to have anti-tumor activity and the time that drug becomes available on the market.  Investigational agents that have been given Group C/Treatment IND designation by the FDA have reproducible efficacy in one or more specific tumor types. Such an agent is likely to alter the pattern of treatment of the disease and can be safely administered by properly trained physicians without specialized supportive care facilities. If a drug meets these criteria CTEP may initiate a formal application to the FDA to authorize Group C distribution for a specific indication. Such approval is not equivalent to formal FDA approval of effectiveness for this indication. Any registered investigator may receive a Group C agent. (from http://ctep.info.nih.gov/requisition/compassion.html)
C15479	Immune-Globulin_Zidovudine	Chemotherapy_Regimen	Immune Globulin/Zidovudine|immune globulin/ZDV
C15480	Sargramostim_Zidovudine	Chemotherapy_Regimen	Sargramostim/Zidovudine|GM-CSF/ZDV
C15481	Antiandrogen_Therapy	Hormone_Therapy	Antiandrogen Therapy|Anti-androgen Therapy|Anti-androgen Treatment|Antiandrogen Treatment|Hormone Deprivation Therapy|Hormone-Deprivation Therapy|antiandrogen therapy	A therapy regimen that utilizes pharmaceuticals to reduce serum levels of hormone. The administration of antiandrogens is a common regimen utilized to treat prostate cancer. Antiandrogens block the function of male hormones or androgens by competing for androgen receptors. These compounds do not lower testosterone; and as a result, are frequently are used in combination with luteinizing hormone-releasing hormone agonists.
C15482	Androgen_Therapy	Hormone_Therapy	Androgen Therapy
C15483	Estrogen_Therapy	Hormone_Therapy	Estrogen Therapy
C15484	Progestin_Therapy	Hormone_Therapy	Progestin Therapy
C15485	Neurotoxicity_Attenuation	Toxicity_Attenuation	Neurotoxicity Attenuation
C15486	Prostaglandin_Inhibition	Biological_Therapy	Prostaglandin Inhibition
C15487	Hypercalcemia_Therapy	Supportive_Care	Hypercalcemia Therapy|bone resorption/hypercalcemia control|hypercalcemia control/bone resorption
C15488	Drug_Modulation	Drug_Development	Drug Modulation|modulation, drug
C15489	Releasing_Factor_Agonist_Therapy	Hormone_Therapy	Releasing Factor Agonist Therapy
C15490	Monoclonal_Antibody_Therapy	Antibody_Therapy	Monoclonal Antibody Therapy
C15491	Premenopausal	Menopausal_Status	Premenopausal|premenopausal	Refers to the time before menopause. Menopause is the time of life when a women's menstrual periods stop permanently; also called "change of life."
C15492	Estrogen_Receptor_Positive	Estrogen_Receptor_Status	Estrogen Receptor Positive|Positive Estrogen Receptor|estrogen receptor positive	ER+. Breast cancer cells that have a protein (receptor molecule) to which estrogen will attach. Breast cancer cells that are ER+ need the hormone estrogen to grow and will usually respond to hormone (antiestrogen) therapy that blocks these receptor sites.
C15493	Estrogen_Receptor_Negative	Estrogen_Receptor_Status	Estrogen Receptor Negative|Negative Estrogen Receptor|estrogen receptor negative	ER-. Breast cancer cells that do not have a protein (receptor molecule) to which estrogen will attach. Breast cancer cells that are ER- do not need the hormone estrogen to grow and usually do not respond to hormone (antiestrogen) therapy that blocks these receptor sites.
C15494	Fatigue_Assessment_and_Management	Supportive_Care	Fatigue Assessment and Management
C15495	Estrogen_Receptor_Status_Unknown	Estrogen_Receptor_Status	Estrogen Receptor Status Unknown|Unknown Status, Estrogen Receptor
C15496	Progesterone_Receptor_Positive	Progesterone_Receptor_Status	Progesterone Receptor Positive|PR+|positive progesterone receptor|progesterone receptor positive	(PR+) PR+. Breast cancer cells that have a protein (receptor molecule) to which progesterone will attach. Breast cancer cells that are PR+ need the hormone progesterone to grow and will usually respond to hormonal therapy.
C15497	Progesterone_Receptor_Negative	Progesterone_Receptor_Status	Progesterone Receptor Negative|PR-|negative progesterone receptor|progesterone receptor negative	(PR-) PR-.  Breast cancer cells that do not have a protein (receptor molecule) to which progesterone will attach. Breast cancer cells that are PR- do not need the hormone progesterone to grow and usually do not respond to hormonal therapy.
C15498	Progesterone_Receptor_Status_Unknown	Progesterone_Receptor_Status	Progesterone Receptor Status Unknown|unknown status, progesterone receptor
C15499	Prior_Oophorectomy	Prior_Therapy	Prior Oophorectomy
C15500	Prior_Estrogen_Therapy	Prior_Hormone_Therapy	Prior Estrogen Therapy
C15501	Prior_Antiestrogen_Therapy	Prior_Hormone_Therapy	Prior Antiestrogen Therapy
C15502	Prior_Progestin_Therapy	Prior_Hormone_Therapy	Prior Progestin Therapy
C15503	Prior_LHRH_Agonist_Therapy	Releasing_Factor_Agonist_Therapy	Prior LHRH Agonist Therapy
C15504	Prior_Androgen_Therapy	Prior_Hormone_Therapy	Prior Androgen Therapy
C15505	Peripheral_Blood_Lymphocyte_Therapy	Adoptive_Immunotherapy	Peripheral Blood Lymphocyte Therapy|peripheral blood lymphocyte therapy	A treatment for Epstein-Barr virus infection or overgrowth of white blood cells (lymphocytes) after an organ or bone marrow transplant.  Specific lymphocytes from a sibling donor are infused into the patient to try and reverse these conditions.
C15506	Anticachectic_Therapy	Palliative_Other_Than_Pain_and_Hospice	Anticachectic Therapy	Treatment to manage or alleviate the fatigue and weight loss often associated with cancer.
C15507	Tumor_Necrosis_Factor_Therapy	Biological_Cancer_Immunotherapy	Tumor Necrosis Factor Therapy
C15508	Antibody_Conjugate_Therapy	Antibody_Therapy	Antibody Conjugate Therapy
C15509	Amino_Acid_Injection	Nutritional_Support	Amino Acid Injection	A type of nutritional support.  It is particularly useful when oral nutrition is unfeasible, impractical or inadequate.
C15510	Growth_Factor_Antagonist_Therapy	Biological_Therapy	Growth Factor Antagonist Therapy
C15511	Infection_Prophylaxis_and_Management	Treatment_of_Infectious_Diseases	Infection Prophylaxis and Management|management, infection prophylaxis
C15512	Prior_Endocrine_Therapy_for_Advanced_Disease	Prior_Hormone_Therapy	Prior Endocrine Therapy for Advanced Disease
C15513	Drug_Extravasation_Therapy	Supportive_Care	Drug Extravasation Therapy|drug extravasation management
C15514	Psychosocial_Assessment_and_Care	Supportive_Care	Psychosocial Assessment and Care|psychosocial assessment|psychosocial care|psychosocial care/assessment|psychosocial studies|psychosocial support
C15515	Colony-Stimulating_Factor_Therapy	Immunotherapy	Colony-Stimulating Factor Therapy
C15516	Fertility_Assessment_and_Management	Supportive_Care	Fertility Assessment and Management|fertility management/assessment
C15517	Catheter_Management	Supportive_Care	Catheter Management|management of catheter
C15518	Clinical_Trials_Information_for_Patients	PDQ_Information_System	Clinical Trials Information for Patients
C15519	Clinical_Trials_Information_for_Physicians	PDQ_Information_System	Clinical Trials Information for Physicians
C15520	Flavone-Acetic-Acid_Interleukin-2	Chemotherapy_Regimen	Flavone Acetic Acid/Interleukin-2|FAA/IL-2
C15521	Antiprogestational_Therapy	Hormone_Therapy	Antiprogestational Therapy
C15522	Interleukin-2_Tumor-Necrosis-Factor	Chemotherapy_Regimen	Interleukin-2/Tumor Necrosis Factor|IL-2/TNF
C15523	Interleukin-2_Tumor-Infiltrating-Lymphocytes	Chemotherapy_Regimen	Interleukin-2/Tumor Infiltrating Lymphocytes|IL-2/TIL
C15524	Tumor_Infiltrating_Lymphocyte_Therapy	Adoptive_Immunotherapy	Tumor Infiltrating Lymphocyte Therapy
C15525	Aromatase_Inhibition	Antiestrogen_Therapy	Aromatase Inhibition|aromatase inhibition	(a-ROW-ma-tays in-hib-ISH-un) Prevention of the formation of estradiol, a female hormone, by interfering with an aromatase enzyme.  Aromatase inhibition is a type of hormone therapy used in postmenopausal women who have hormone-dependent breast cancer.
C15526	_5a-Reductase_Inhibition	Antiandrogen_Therapy	5a-Reductase Inhibition
C15527	Interleukin-2_Sargramostim	Chemotherapy_Regimen	Interleukin-2/Sargramostim|GM-CSF/IL-2
C15528	Interleukin-2_Monoclonal-Antibody-Lym-1	Chemotherapy_Regimen	Interleukin-2/Monoclonal Antibody Lym-1|IL-2/MOAB Lym-1
C15529	Bone_Metastases_Prevention	Cancer_Prevention	Bone Metastases Prevention|prevention of bone metastases|prevention, bone metastases
C15530	Interleukin-2_Monoclonal-Antibody-R24	Chemotherapy_Regimen	Interleukin-2/Monoclonal Antibody R24|IL-2/MOAB R24
C15531	Monoclonal-Antibody-R24_Sargramostim	Chemotherapy_Regimen	Monoclonal Antibody R24/Sargramostim|GM-CSF/MOAB R24
C15532	in_vitro-Treated_Peripheral_Blood_Stem_Cell_Transplantation	Peripheral_Blood_Stem_Cell_Transplantation	in vitro-Treated Peripheral Blood Stem Cell Transplantation|in vitro-treated PBPC transplantation|in vitro-treated peripheral blood progenitor cell transplantation
C15533	Chemoprotection	Cancer_Treatment	Chemoprotection	The use of drugs to protect normal tissue from damage by cancer therapy agents.
C15534	Cardiotoxicity_Attenuation	Toxicity_Attenuation	Cardiotoxicity Attenuation
C15535	Urothelial_Toxicity_Attenuation	Toxicity_Attenuation	Urothelial Toxicity Attenuation
C15536	Bone_Marrow_Suppression	Myelosuppressive_Therapy	Bone Marrow Suppression
C15537	Macrophage_Colony-Stimulating_Factor_Monoclonal_Antibody_R24	Cancer_Immunotherapy	Macrophage Colony-Stimulating Factor/Monoclonal Antibody R24|M-CSF/MOAB R24
C15538	Protocol_Treatment_Arm	Treatment_Regimen	Protocol Treatment Arm|Arm|arm, protocol treatment|treatment arm, protocol	A specific treatment protocol used in a clinical trial.
C15539	Treatment_Referral_Center_Protocol	Treatment_Regimen	Treatment Referral Center Protocol
C15540	Antiprolactin_Therapy	Hormone_Therapy	Antiprolactin Therapy
C15541	Sleep_Disorders_Therapy	Supportive_Care	Sleep Disorders Therapy
C15542	Antibody_Therapy	Immunotherapy	Antibody Therapy|antibody therapy	Treatment with an antibody, a substance that can directly kill specific tumor cells or stimulate the immune system to kill tumor cells.
C15543	Interleukin_Therapy	Immunotherapy	Interleukin Therapy
C15544	Anti-Cytokine_Therapy	Immunotherapy	Anti-Cytokine Therapy
C15545	Leukocyte_Therapy	Adoptive_Immunotherapy	Leukocyte Therapy
C15546	Breast_Cancer_Screening	Cancer_Screening	Breast Cancer Screening|Screening for Breast Cancer	Early detection of breast cancer involving asymptomatic women. Generally done in the population with higher risk, due to environmental or genetic factors.
C15547	Screening_for_Skin_Cancer	Cancer_Screening	Screening for Skin Cancer|early detection of skin cancer|skin cancer early detection|skin cancer screening
C15548	Screening_for_Oral_Cancer	Cancer_Screening	Screening for Oral Cancer|early detection for oral cancer|oral cancer early detection|oral cancer screening
C15549	Screening_for_Colorectal_Cancer	Cancer_Screening	Screening for Colorectal Cancer|colorectal cancer early detection|colorectal cancer screening|early detection of colorectal cancer
C15550	Screening_for_Prostate_Cancer	Cancer_Screening	Screening for Prostate Cancer|early detection of prostate cancer|prostate cancer early detection|prostate cancer screening
C15551	Cervical_Cancer_Screening	Cancer_Screening	Cervical Cancer Screening|Cervical Cancer Early Detection|Early Detection of Cervical Cancer|Screening for Cervical Cancer
C15552	Screening_for_Testicular_Cancer	Cancer_Screening	Screening for Testicular Cancer|early detection of testicular cancer|testicular cancer early detection|testicular cancer screening
C15553	Breast_Cancer_Prevention	Cancer_Prevention	Breast Cancer Prevention|prevention of breast cancer	Anything, such as drug administration or lifestyle changes, designed to inhibit the onset of breast cancer.
C15554	Prevention_of_Colorectal_Cancer	Cancer_Prevention	Prevention of Colorectal Cancer|Colorectal Cancer Prevention
C15555	Prevention_of_Head_and_Neck_Cancer	Cancer_Prevention	Prevention of Head and Neck Cancer|head and neck cancer prevention
C15556	Prevention_of_Skin_Cancer	Cancer_Prevention	Prevention of Skin Cancer|skin cancer prevention
C15557	Prevention_of_Cervical_Cancer	Cancer_Prevention	Prevention of Cervical Cancer|cervical cancer prevention
C15558	Prevention_of_Lung_Cancer	Cancer_Prevention	Prevention of Lung Cancer|lung cancer prevention
C15559	Prevention_of_Esophageal_Cancer	Cancer_Prevention	Prevention of Esophageal Cancer|esophageal cancer prevention
C15560	Interleukin-3_Thiotepa	Chemotherapy_Regimen	Interleukin-3/Thiotepa|IL-3/TSPA
C15561	Cancer_Prevention_Intervention	Cancer_Prevention	Cancer Prevention Intervention
C15562	Interleukin-3_Melphalan	Chemotherapy_Regimen	Interleukin-3/Melphalan|IL-3/L-PAM
C15563	Interleukin-3_Zidovudine	Chemotherapy_Regimen	Interleukin-3/Zidovudine|IL-3/ZDV
C15564	Prior_Adjuvant_Chemotherapy	Prior_Biologic_Therapy	Prior Adjuvant Chemotherapy
C15565	Prior_Adjuvant_Endocrine_Hormonal_Therapy	Prior_Hormone_Therapy	Prior Adjuvant Endocrine/Hormonal Therapy
C15566	Neoadjuvant_Study	Adjuvant_Study	Neoadjuvant Study|study, neoadjuvant
C15567	Screening_for_Gastric_Cancer	Cancer_Screening	Screening for Gastric Cancer|early detection of gastric cancer|early detection of stomach cancer|gastric cancer early detection|gastric cancer screening|screening for stomach cancer|stomach cancer early detection|stomach cancer screening
C15568	Antiangiogenesis_Therapy	Chemotherapy	Antiangiogenesis Therapy|Angiogenesis Inhibition|Anti-Angiogenesis|Antiangiogenesis|antiangiogenesis	Antiangiogenesis therapy is the use of drugs or other substances to stop cancerous tumors from developing new blood vessels. Without a blood supply, tumors can't grow much larger than the eye of a needle
C15569	Bone_Marrow_Ablation	Bone_Marrow_Suppression	Bone Marrow Ablation|bone marrow ablation	The destruction of bone marrow using radiation or drugs.
C15570	Pressor_Support	Supportive_Care	Pressor Support
C15571	Differentiation_Therapy	Cancer_Treatment	Differentiation Therapy|therapy, differentiation	Drug therapy aimed at forcing cancer cells to resume the process of maturation and therefore to induce tumor to a more differentiated, less aggressive state. Differentiation therapy restrains cancer cells growth and facilitates the application of more conventional therapies.
C15572	Prevention_of_Prostate_Cancer	Cancer_Prevention	Prevention of Prostate Cancer|prostate cancer prevention
C15573	Tumor-Draining_Lymph_Node_Lymphocyte_Therapy	Adoptive_Immunotherapy	Tumor-Draining Lymph Node Lymphocyte Therapy
C15574	Interleukin-3_Interleukin-6	Chemotherapy_Regimen	interleukin-3/interleukin-6|IL-3/IL-6
C15575	Screening_for_Lung_Cancer	Cancer_Screening	Screening for Lung Cancer|early detection of lung cancer|lung cancer early detection|lung cancer screening
C15576	Screening_for_Ovarian_Cancer	Cancer_Screening	Screening for Ovarian Cancer|early detection of ovarian cancer|ovarian cancer early detection|ovarian cancer screening
C15577	Anti-Tumor_Necrosis_Factor_Therapy	Biological_Cancer_Immunotherapy	Anti-Tumor Necrosis Factor Therapy|anti-TNF therapy|anti-TNF-alpha therapy
C15578	in_vitro_Sensitivity-Directed_Chemotherapy	Chemotherapy	in vitro Sensitivity-Directed Chemotherapy	Uses the results of a chemosensitivity testing assay to tailor the treatment to the individual.
C15579	Interleukin-2_Tumor-Necrosis-Factor-Receptor-IgG-Chimera	Chemotherapy_Regimen	Interleukin-2/Tumor Necrosis Factor Receptor IgG Chimera|IL-2/TNFR:Fc
C15580	Intra-Operative_Blood_Salvage	Blood_Transfusion	Intra-Operative Blood Salvage|intraoperative blood salvage
C15581	Intraperitoneal_Therapy	Regional_Chemotherapy	Intraperitoneal Therapy|Intraperitoneal Chemotherapy
C15582	Prevention_of_Aerodigestive_Tract_Cancer	Cancer_Prevention	Prevention of Aerodigestive Tract Cancer|aerodigestive tract cancer prevention
C15583	Sargramostim_Tumor-Necrosis-Factor	Chemotherapy_Regimen	Sargramostim/Tumor Necrosis Factor|GM-CSF/TNF
C15584	Quality-of-Life_Assessment	Healthcare_Activity	Quality-of-Life Assessment|quality of life assessment
C15585	Targeted_Fusion_Protein_Therapy	Biological_Therapy	Targeted Fusion Protein Therapy	Drug therapy in which the drug is a fusion protein generated by molecular biology procedures.  The fusion protein combines a cell targeting moiety, such as an antibody fragment, with an effector moiety, like a bacterial toxin.
C15586	BiSpecific-Antibody-520C9XH22_Interferon-Gamma	Chemotherapy_Regimen	Bispecific Antibody 520C9XH22/Interferon Gamma|BsAb 520C9xH22/IFN-G
C15587	Bone_Marrow_Ablation_with_Stem_Cell_Support	Bone_Marrow_Ablation	Bone Marrow Ablation with Stem Cell Support
C15588	Interleukin-6_Sargramostim	Chemotherapy_Regimen	interleukin-6/sargramostim|GM-CSF/IL-6
C15589	Melphalan_Tumor-Necrosis-Factor	Chemotherapy_Regimen	Melphalan/Tumor Necrosis Factor|L-PAM/TNF
C15590	Monoclonal-Antibody-3F8_Sargramostim	Chemotherapy_Regimen	Monoclonal Antibody 3F8/Sargramostim|GM-CSF/MOAB 3F8
C15591	Prevention_of_Ovarian_Cancer	Cancer_Prevention	Prevention of Ovarian Cancer|ovarian cancer prevention
C15592	Incomplete-Freunds-Adjuvant_MART-1	Retired_Concepts	Incomplete Freund's Adjuvant/MART-1|IFA/MART-1
C15593	gp100-Antigen_Interleukin-2	Chemotherapy_Regimen	gp100 Antigen/Interleukin-2|gp100/IL-2
C15594	Interleukin-2_Monoclonal-Antibody-HuG1-M195	Chemotherapy_Regimen	Interleukin-2/Monoclonal Antibody HuG1-M195|IL-2/MOAB HuM195
C15595	Transitional_Care_Planning	Supportive_Care	Transitional Care Planning
C15596	Interleukin-2_Vinblastine	Chemotherapy_Regimen	Interleukin-2/Vinblastine|IL-2/VBL
C15597	Incomplete-Freunds-Adjuvant_Interleukin-12_MART-1-Antigen	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/Interleukin-12/MART-1 Antigen|IFA/IL-12/MART-1
C15598	BiSpecific-Antibody-520C9XH22_Filgrastim	Chemotherapy_Regimen	Bispecific Antibody 520C9XH22/Filgrastim|BsAb 520C9xH22/G-CSF
C15599	Hormone_Replacement_Therapy	Hormone_Therapy|Replacement_Therapy	Hormone Replacement Therapy|HRT|Hormone Replacement Rx|hormone replacement therapy	Hormones (estrogen, progesterone, or both) given to postmenopausal women or women who have had their ovaries surgically removed, to replace the estrogen no longer produced by the ovaries.
C15600	Phase_I_Trial	Clinical_Trial	Phase I Trial|Clinical Trials, Phase I|Early-Stage Clinical Trials|Phase 1 Study|Phase I Clinical Trials|Phase I Protocol|Phase I Study|phase I trial	The first step in testing a new treatment in humans. These studies test the best way to give a new treatment (for example, by mouth, intravenous infusion, or injection) and the best dose. The dose is usually increased a little at a time in order to find the highest dose that does not cause harmful side effects. Because little is known about the possible risks and benefits of the treatments being tested, phase I trials usually include only a small number of patients who have not been helped by other treatments.
C15601	Phase_II_Trial	Clinical_Trial	Phase II Trial|Clinical Trials, Phase II|Phase 2 Study|Phase II Clinical Trial|Phase II Protocol|Phase II Study|phase II trial	A study to test whether a new treatment has an anticancer effect (for example, whether it shrinks a tumor or improves blood test results) and whether it works against a certain type of cancer.
C15602	Phase_III_Trial	Clinical_Trial	Phase III Trial|Clinical Trials, Phase III|Phase 3 Study|Phase III Clinical Trial|Phase III Protocol|Phase III Study|Phase III Trials|phase III trial	A study to compare the results of people taking a new treatment with the results of people taking the standard treatment (for example, which group has better survival rates or fewer side effects). In most cases, studies move into phase III only after a treatment seems to work in phases I and II. Phase III trials may include hundreds of people.
C15603	Phase_IV_Trial	Clinical_Trial	Phase IV Trial|Clinical Trials, Phase IV|Phase 4 Study|Phase IV Clinical Trials|Phase IV Study|phase IV trial	After a treatment has been approved and is being marketed, it is studied in a phase IV trial to evaluate side effects that were not apparent in the phase III trial. Thousands of people are involved in a phase IV trial.
C15604	Chemoprevention	Cancer_Prevention	Chemoprevention|cancer chemoprevention|chemoprevention|chemoprevention of cancer	(KEE-mo-pre-VEN-shun) The use of drugs, vitamins, or other agents to try to reduce the risk of, or delay the development or recurrence of, cancer.
C15605	Nutrition_Trace_Elements	Nutrition_Dietary_Components	Nutrition, Trace Elements|Micronutrients|Trace Element Nutrition|Trace Nutrients	Role of trace elements in cancer causation or prevention and in general health.
C15606	Acupressure	Massage_and_Body_Techniques	Acupressure|Ischemic Compression|acupressure	The application of non-invasive finger pressure along energy points throughout the body in order to relieve pain and induce a feeling of well-being.
C15607	Clinical_Diagnosis	Diagnosis	Clinical Diagnosis	A diagnosis made from a study of the signs and symptoms of a disease. (On-line Medical Dictionary)
C15608	Staging	Healthcare_Activity	Staging|staging	(STAY-jing) Performing exams and tests to learn the extent of the cancer within the body, especially whether the disease has spread from the original site to other parts of the body. It is important to know the stage of the disease in order to plan the best treatment.
C15609	Anastomosis	Surgical_Procedure	Anastomosis|anastomosis	(an-AS-ta-MO-sis) A procedure to connect healthy sections of tubular structures in the body after the diseased portion has been surgically removed.
C15610	Aspirin_Interferon-Alfa	Chemotherapy_Regimen	Aspirin/Interferon Alfa|ASA/IFN-A
C15611	Interferon-Alfa_Monoclonal-Antibody-CC49	Chemotherapy_Regimen	Interferon Alfa/Monoclonal Antibody CC49|IFN-A/MOAB CC49
C15612	Interleukin-2_Monoclonal-Antibody-OKT3	Chemotherapy_Regimen	interleukin-2/Monoclonal Antibody OKT3|IL-2/MOAB OKT3
C15613	Interleukin-2_Monoclonal-Antibody-OKT3_Tumor-Necrosis-Factor	Chemotherapy_Regimen	interleukin-2/Monoclonal Antibody OKT3/Tumor Necrosis Factor|IL-2/MOAB OKT3/TNF
C15614	Interleukin-2_Monoclonal-Antibody-OKT3_Pentoxifylline	Chemotherapy_Regimen	interleukin-2/Monoclonal Antibody OKT3/pentoxifylline|IL-2/MOAB OKT3/PTX
C15615	gp100-Antigen_Incomplete-Freunds-Adjuvant	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant|gp100 Antigen with Incomplete Freund's Adjuvant|gp100/IFA
C15617	Monoclonal-Antibody-17-1A_sargramostim	Chemotherapy_Regimen	Monoclonal Antibody 17-1A/sargramostim|GM-CSF/MOAB 17-1A
C15618	Cancer_and_Suicide	Social_Aspects_of_Cancer	Cancer and Suicide|suicide and cancer
C15619	Edetate-Calcium-Disodium_Interferon-Alfa_Monoclonal-Antibody-CC49	Chemotherapy_Regimen	Edetate Calcium Disodium/Interferon Alfa/Monoclonal Antibody CC49|EDTA/IFN-A/MOAB CC49
C15620	Antibiotic_Therapy	Treatment_of_Infectious_Diseases	Antibiotic Therapy|treatment of bacterial infectious disease	Treat bacterial infections with antibiotics
C15621	H2_Receptor_Antagonist_Therapy	Palliative_Other_Than_Pain_and_Hospice	H2 Receptor Antagonist Therapy
C15622	Radioimmunoguided_Surgery	Imaging_Guided_Therapy	Radioimmunoguided Surgery|Radioguided Surgery|radioimmunoguided surgery	A procedure that uses radiolabeled substances to detect tumors for surgical removal.
C15623	Intraoperative_Radiation_Therapy	Local_Therapy|Radiation_Therapy	Intraoperative Radiation Therapy|IORT|Intraoperative Radiotherapy|intraoperative radiation therapy|radiotherapy, intraoperative	IORT. Radiation treatment aimed directly at a tumor during surgery.
C15624	_9-cis-Retinoic-Acid_Interferon-Alfa	Chemotherapy_Regimen	9-cis-Retinoic Acid/Interferon Alfa|9-CRA/IFN-A	A combination drug therapy.
C15625	QS21_Tyrosinase-Peptide	Chemotherapy_Regimen	QS21/Tyrosinase Peptide
C15626	Neuroendocrine_Therapy	Hormone_Therapy	Neuroendocrine Therapy
C15627	Interferon-Alfa_Monoclonal-Antibody-CC49_Paclitaxel	Chemotherapy_Regimen	Interferon Alfa/Monoclonal Antibody CC49/Paclitaxel|IFN-A/MOAB CC49/TAX
C15628	Interferon-Alfa_Monoclonal-Antibody-CC49_Pentetic-Acid	Chemotherapy_Regimen	Interferon Alfa/Monoclonal Antibody CC49/Pentetic Acid|DTPA/IFN-A/MOAB CC49
C15629	Keyhole-Limpet-Hemocyanin_MUC-1-Antigen	Chemotherapy_Regimen	Keyhole Limpet Hemocyanin/MUC-1 Antigen|KLH/MUC-1|KLH/MUC-1 Antigen|KLH/Mucin Peptide|Keyhole Limpet Hemocyanin/Mucin Peptide
C15630	Vegan_Diet	Diet	Vegan Diet	Men who eat a vegan diet have lower levels of IGF-I, a protein associated with prostate cancer.  These findings suggest that a diet without meat or dairy products could reduce the risk of prostate cancer. (from Medscape)
C15631	Aspiration	Surgical_Procedure	Aspiration|aspiration	(as-per-AY-shun) Removal of fluid from a lump, often a cyst, with a needle and a syringe.
C15632	Chemotherapy	Cancer_Treatment	Chemotherapy|CT|Chemo|Chemotherapy, Cancer, General|chemotherapy	(kee-mo-THER-a-pee) Treatment with anticancer drugs.
C15633	Cancer_Pain_Management	Cancer_Intervention	Cancer Pain Management|management of cancer pain
C15634	_70-kD-Heat-Shock-Protein_MUC-1-Antigen	Chemotherapy_Regimen	70-kD Heat-Shock Protein/MUC-1 Antigen|70-kD Heat-Shock Protein/Mucin/Peptide|HSP70/MUC-1|HSP70/MUC-1 Antigen|HSP70/Mucin/Peptide	A fusion protein of the MUC-1 colorectal cancer surface marker with HSP70 as a carrier.  In trials as a cancer vaccine.
C15635	gp100-Antigen_Incomplete-Freunds-Adjuvant_Interleukin-2	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant/interleukin-2|gp100/IFA/IL-2
C15636	gp100-Antigen_Incomplete-Freunds-Adjuvant_Interleukin-12	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant/Interleukin-12|gp100/IFA/IL-12
C15637	gp100-Antigen_Interleukin-2_MART-1-Antigen	Chemotherapy_Regimen	gp100 Antigen/interleukin-2/MART-1 Antigen|gp100/IL-2/MART-1
C15638	Genetic_Testing_for_Cancer_Risk	Genetic_Testing	Genetic Testing for Cancer Risk	Analyzing DNA to look for a genetic alteration that may indicate an increased risk for developing a cancer.
C15639	Level_of_Evidence	Clinical_Testing	Level of Evidence
C15640	Umbilical_Cord_Blood_Transplantation	Stem_Cell_Transplantation	Umbilical Cord Blood Transplantation|Cord Blood Transplantation|UCB transplantation|umbilical cord blood transplantation	The injection of umbilical cord blood to restore an individual's own blood production system suppressed by anticancer drugs, radiation therapy, or both. It is being studied in the treatment of cancer and severe blood disorders such as aplastic anemia. Cord blood contains high concentrations of stem cells needed to produce new blood cells.
C15641	Screening_for_Neuroblastoma	Cancer_Screening	Screening for Neuroblastoma|early detection of neuroblastoma|neuroblastoma early detection|neuroblastoma screening
C15642	Epidural_Block	Anesthesia_Procedure	Epidural Block|epidural block	An injection of an anesthetic drug into the space between the wall of the spinal canal and the covering of the spinal cord.
C15643	Neck_Dissection	Head_and_Neck_Surgery|Lymph_Node_Dissection	Neck Dissection|neck dissection	(dye-SEK-shun) Surgery to remove lymph nodes and other tissues in the neck.
C15644	Bone_Marrow_Aspiration	Aspiration	Bone Marrow Aspiration|BMCELLTY|Bone Marrow Cellularity|bone marrow aspiration	(as-per-AY-shun) The removal of a small sample of bone marrow (usually from the hip) through a needle for examination under a microscope.
C15645	Other_Therapy	Treatment	Other Therapy
C15646	Nutrition_Calories	Nutrition_Dietary_Components	Nutrition, Calories|calorie	A measurement of the energy content of food.  The body needs calories as "fuel" to perform all of its functions, such as breathing, circulating the blood, and physical activity.  When a person is sick, their body may need extra calories to fight fever or other problems.
C15647	Anterior_Mediastinotomy	Mediastinotomy	Anterior Mediastinotomy|Chamberlain procedure|anterior mediastinotomy	(MEE-dee-a-stin-AH-toe-mee) A procedure in which a tube is inserted into the chest to view the tissues and organs in the area between the lungs and between the breastbone and heart. The tube is inserted through an incision next to the breastbone. This procedure is usually used to get a tissue sample from the lymph nodes on the left side of the chest.
C15648	Continuous_Infusion	Infusion_Technique	Continuous Infusion|continuous infusion	The administration of a fluid into a blood vessel, usually over a prolonged period of time.
C15649	Diet_Research	Nutritional_Study	Diet Research
C15650	Electron_Beam_Therapy	Radiation_Ionizing_Radiotherapy	Electron Beam Therapy	Radiation therapy using electron beam
C15651	High-Dose_Rate_Brachytherapy	Radiation_Brachytherapy	High-Dose Rate Brachytherapy
C15652	Image_Guided_Biopsy	Biopsy	Image Guided Biopsy|Biopsy, Image Guided|Image-Guided Biopsy|Imaging Guided Biopsy
C15653	Drug_Formulation	Drug_Development	Drug Formulation Process|Drug Formulation|Formulation	The act or process of developing or preparing a mixture of ingredients to create a desired end drug product, such as a specific flavor, aroma, or polymer; or the desired final drug product itself; also, a listing of the ingredients and composition of the dosage form.
C15654	Fractionation	Radiation_Therapy	Fractionation|FRACN|Fractionation Radiotherapy|fractionation	Dividing the total dose of radiation therapy into several smaller, equal doses delivered over a period of several days.
C15655	Thoracic_Surgical_Procedures	Surgical_Procedure	Thoracic Surgical Procedures|chest surgery|thoracic surgery
C15656	Neurosurgical_Procedure	Surgical_Procedure	Neurosurgical Procedure|Neurological Surgery|Neurosurgery|Neurosurgical Procedures|Surgery, Neurological	see NTs for specifics.
C15657	Blood_Treatment	Treatment	Blood Treatment	General term for hemodialysis, plasmapheresis, and related procedures involving autologous removal, alteration, and replacement of patients' blood or blood components.  Also includes blood transfusions. (from CSP98)
C15658	Cancer_and_Nutrition	Cancer_Research_Project	Cancer and Nutrition	Research on a variety of aspects of diet, nutrition and cancer (e.g. the role of diet in preventing and treating cancer), or the effect of cancer on one's nutritional status; for the effect of diet as a factor or cause of cancer, use NUTRITION RELATED NEOPLASM/CANCER.
C15659	Aging_and_Nutrition	Nutritional_Study	Aging and Nutrition	The study of how nutritional needs change with aging.
C15660	Vaccine_Development	Vaccine_Research	Vaccine Development	Suspensions of killed or attenuated microorganisms (bacteria, viruses, or rickettsiae), or of antigenic proteins derived from them, administered for the prevention, amelioration, or treatment of infectious diseases or cancer. Any aspect of vaccine research, development, testing, etc., for diseases other than AIDS. A vaccine must involve the administration of an antigen to induce an active and specific immune response. Induction of passive immunity does not constitute a vaccine although the term is sometimes misused for this process.
C15661	ATCC	Other_Resources	ATCC|American Type Culture Collection	American Type Culture Collection.  ATCC is a global nonprofit bioscience organization (located at 10801 University Boulevard, Manassas, VA 20110-2209 703-365-2700) that provides biological products, technical services, and educational programs to private industry, government, and academic organizations around the world.  Biological products for academic and industrial labs, as well as educational and technical services.  For the collection, preservation and distribution of cultures of living microorganisms, viruses, DNA probes, plants, and human and animal
C15662	Neuroprotection	Chemoprotection	Neuroprotection	The use of drugs to protect nerve cells from damage by cancer therapy agents.
C15663	Nicotine_Gum	Pharmacologic_Substance	Nicotine Gum|Nicorette
C15664	Technology_Development	Research_Activity	Technology Development
C15665	Neoadjuvant_Therapy	Cancer_Treatment	Neoadjuvant Therapy|Induction Therapy|NEOADJ|Neoadjuvant|induction therapy|neoadjuvant therapy	Treatment designed to be used as a first step toward shrinking the cancer and in evaluating response to drugs and other agents. Induction therapy is followed by additional therapy to eliminate whatever cancer remains.
C15666	Radiofrequency_Interstitial_Ablation	Local_Therapy	Radiofrequency Interstitial Ablation|Radiofrequency Ablation|radiofrequency ablation	A therapeutic procedure to eradicate or reduce small tumors using radiowaves to generate heat. The procedure is performed by the insertion of a thin needle through the skin and into a tumor, which is guided by computed tomography (CT) or ultrasound. Electrical energy delivered through this needle (electrode) heats and destroys the tumor. This therapeutic option is widely utilized by patients that have inoperable cancers, or are unsuitable chemotherapy candidates.
C15667	Sentinel_Lymph_Node_Biopsy	Biopsy	Sentinel Lymph Node Biopsy|Sentinel Node Biopsy|sentinel lymph node biopsy	Removal and examination of the sentinel node(s) (the first lymph node(s) to which cancer cells are likely to spread from a primary tumor). To identify the sentinel lymph node(s), the surgeon injects a radioactive substance, blue dye, or both near the tumor.  The surgeon then uses a scanner to find the sentinel lymph node(s) containing the radioactive substance or looks for the lymph node(s) stained with dye. The surgeon then removes the sentinel node(s) to check for the presence of cancer cells.
C15668	Prevention_of_Liver_Cancer	Cancer_Prevention	Prevention of Liver Cancer|liver cancer prevention
C15669	Cancer_Prevention	Prevention	Cancer Prevention	All methods of preventing cancer including limit of exposure to carcinogens and infectious agents, diet, education, etc
C15670	Thermal_Ablation_Therapy	Surgical_Procedure	Thermal Ablation Therapy|thermal ablation	A procedure using heat to remove tissue or a part of the body, or destroy its function.  For example, to remove the lining of the uterus, a catheter is inserted through the cervix into the uterus, a balloon at the end of the catheter is inflated, and fluid inside the balloon is heated to destroy the lining of the uterus.
C15671	Screening_for_Endometrial_Cancer	Cancer_Screening	Screening for Endometrial Cancer|early detection of endometrial cancer|endometrial cancer early detection|endometrial cancer screening
C15672	Hot_Flashes_Attenuation	Menopausal_Symptoms_Attenuation	Hot Flashes Attenuation
C15673	Keratinocyte_Growth_Factor_Therapy	Biological_Therapy	Keratinocyte Growth Factor Therapy
C15674	Prevention_of_Endometrial_Cancer	Cancer_Prevention	Prevention of Endometrial Cancer|endometrial cancer prevention
C15675	Adjuvant_Therapy	Cancer_Treatment	Adjuvant Therapy|adjuvant therapy	(AD-joo-vant) Treatment given after the primary treatment to increase the chances of a cure. Adjuvant therapy may include chemotherapy, radiation therapy, hormone therapy, or biological therapy.
C15676	Androgen_Suppression	Hormone_Therapy	Androgen Suppression|androgen suppression	Treatment to suppress or block the production of male hormones. Androgen suppression is achieved by surgical removal of the testicles, by taking female sex hormones, or by taking other drugs, antiandrogens. Also called androgen ablation.
C15677	Axillary_Lymph_Node_Dissection	Lymph_Node_Dissection	Axillary Lymph Node Dissection|Axillary Dissection|axillary dissection|axillary lymph node dissection	(AK-sil-air-ee) Surgery to remove lymph nodes found in the armpit region.
C15678	Bolus_Infusion	Infusion_Technique	Bolus Infusion|Bolus|bolus|bolus infusion	A single dose of drug usually injected into a blood vessel over a short period of time.
C15679	Consolidation_Therapy	Chemotherapy	Consolidation Therapy|consolidation therapy	Chemotherapy treatments given after induction chemotherapy to further reduce the number of cancer cells.
C15680	Core_Biopsy	Needle_Biopsy	Core Biopsy|Biopsy, Core Needle|core biopsy	The removal of a tissue sample with a needle for examination under a microscope.
C15681	Cytotoxic_Chemotherapy	Chemotherapy	Cytotoxic Chemotherapy|Cytotoxic|Cytotoxic Therapy|cytotoxic chemotherapy	Anticancer drugs that kill cells, especially cancer cells.
C15682	Dose-Rate	Treatment_Regimen	Dose-Rate|dose-rate	The strength of a treatment given over a period of time.
C15683	Epidural	Intrathecal_Chemotherapy	Epidural Chemotherapy|epidural	Having to do with the space between the wall of the spinal canal and the covering of the spinal cord. An epidural injection is given into this space.
C15684	Hyperthermic_Perfusion	Perfusion	Hyperthermic Perfusion|hyperthermic perfusion	A procedure in which a warmed solution containing anticancer drugs is used to bathe, or is passed through the blood vessels of, the tissue or organ containing the tumor.
C15685	Incubated	in_vitro	Incubated|incubated	Grown in the laboratory under controlled conditions. (For instance, white blood cells can be grown in special conditions so that they attack specific cancer cells when returned to the body.)
C15686	Isolated_Hepatic_Perfusion	Isolated_Perfusion	Isolated Hepatic Perfusion|isolated hepatic perfusion	A procedure in which a catheter is placed into the artery that provides blood to the liver; another catheter is placed into the vein that takes blood away from the liver. This temporarily separates the liver's blood supply from blood circulating throughout the rest of the body and allows high doses of anticancer drugs to be directed to the liver only.
C15687	Local_Therapy	Cancer_Treatment	Local Therapy|Localized Therapy|local therapy	Treatment that affects cells in the tumor and the area close to it.
C15688	Maintenance_Therapy	Chemotherapy	Maintenance Therapy|maintenance therapy	Treatment that is given to help a primary (original) treatment keep working. Maintenance therapy is often given to help keep cancer in remission.
C15689	Drug_Resistance_Inhibition	Treatment	Drug Resistance Inhibition|Multidrug Resistance Inhibition|multi-drug resistance inhibition|multidrug resistance inhibition	Treatment used to make cancer cells less resistant to anticancer drugs.
C15690	Myelosuppressive_Therapy	Treatment	Myelosuppressive Therapy|myelosuppressive therapy	Treatment that inhibits blood cell production.
C15691	Ovarian_Ablation	Antiestrogen_Therapy	Ovarian Ablation|ovarian ablation|ovarian suppression	Surgery, radiation therapy, or a drug treatment to stop the functioning of the ovaries.
C15692	Perimenopausal	Menopausal_Status	Perimenopausal|perimenopausal	The time of a woman's life when menstrual periods become irregular. Refers to the time near menopause.
C15693	Phase_I_II_Trial	Clinical_Trial	Phase I/II Trial|Phase I/II trial|Trial Phase 1/2	A trial to study the safety, dosage levels, and response to a new treatment.
C15694	Phase_II_III_Trial	Clinical_Trial	Phase II/III Trial|Trial Phase 2/3|phase II/III trial	A trial to study response to a new treatment and the effectiveness of the treatment compared with the standard treatment regimen.
C15695	Quadrantectomy	Breast_Conservation_Treatment	Quadrantectomy|quadrantectomy	Surgical removal of the region of the breast (approximately one quarter) containing cancer.
C15696	Radiation_Surgery	Local_Therapy|Radiation_Therapy	Radiation Surgery|Radiosurgery|Stereotactic External Beam Irradiation|radiation surgery|radiosurgery	A radiation therapy technique that delivers radiation directly to the tumor while sparing the healthy tissue.
C15697	Treatment_Regimen	Treatment	Treatment Regimen|RGM|Regimen|Treatment Protocol|Treatment Schedule|regimen	A treatment plan that specifies the dosage, the schedule, and the duration of treatment.
C15698	Systemic_Therapy	Cancer_Treatment	Systemic Therapy|SYS-TX|systemic therapy	(sis-TEM-ik THER-a-pee) Treatment using substances that travel through the bloodstream, reaching and affecting cells all over the body.
C15699	T-Cell_Depletion	Immunosuppressive_Therapy	T-Cell Depletion|T-cell depletion	Treatment to destroy T cells, which play an important role in the immune response. Elimination of T cells from a bone marrow graft from a donor may reduce the chance of an immune reaction against the recipient's tissues.
C15700	Total_Estrogen_Blockade	Antiestrogen_Therapy	Total Estrogen Blockade|total estrogen blockade	Therapy used to eliminate estrogen in the body. This may be done with surgery, radiation therapy, chemotherapy, or a combination of these procedures.
C15701	Total_Hysterectomy	Hysterectomy	Total Hysterectomy|complete hysterectomy|total hysterectomy	A surgical procedure to remove the uterine body and cervix. -- 2004
C15702	Video-Assisted_Surgery	Imaging_Guided_Therapy	Video-Assisted Surgery|video-assisted resection|video-assisted surgery	Surgery that is aided by the use of a video camera that projects and enlarges the image on a television screen.
C15703	Colposcopic_Biopsy	Endoscopic_Biopsy	Colposcopic Biopsy
C15704	Antifungal_Therapy	Treatment_of_Infectious_Diseases	Antifungal Therapy|treatment of fungal infectious disease
C15705	Transurethral_Resection	Excision	Transurethral Resection|TUR|transurethral resection	(TRANZ-yoo-REE-thral ree-SEK-shun) Surgery performed with a special instrument inserted through the urethra.
C15706	Bryostatin_1_Interleukin-2_Ionomycin	Retired_Concepts	Bryostatin 1/Interleukin-2/Ionomycin|BRYO/IL-2/IONO|bryostatin 1/interleukin-2/ionomycin
C15707	Electroporation_Therapy	Local_Therapy	Electroporation Therapy|EPT|electroporation therapy	EPT. Treatment that generates electrical pulses through an electrode placed in a tumor to enhance the ability of anticancer drugs to enter tumor cells.
C15708	Prevention_of_Oral_Cancer	Cancer_Prevention	Prevention of Oral Cancer|oral cancer prevention
C15709	Genetic_Testing	Screening	Genetic Testing|genetic testing	Analyzing DNA to look for a genetic alteration that may indicate an increased risk for developing a specific disease or disorder.
C15710	Nicotine_Replacement	Biological_Therapy	Nicotine Replacement|NRT|Nicotine Replacement Therapy	Therapy to help control nicotine withdrawal symptoms during tobacco cessation
C15711	Prevention_Research	Research	Prevention Research	Studies identifying, testing, and implementing interventions among groups of individuals that are designed to prevent the initiation of a substance, such as tobacco or alcohol.
C15712	Secondary_Prevention	Prevention	Secondary Prevention|Prevention, Secondary	Procedures or treatment processes designed to prevent complications (e.g., modifying a drug or surgical procedure to prevent complications).
C15713	Religion_and_Spirituality	Mind-Body_Intervention	Religion and Spirituality	NIH: Used as subcategory of Mind-Body Medicine in CAM.  This area deals with the non-behavioral aspects of spirituality and religion that examine their relationship to biological function or clinical conditions.  It included activities such as prayer, soul retrieval, spiritual healing, Included are: Prayer, Confession, Nonlocality, Nontemporality, Consciousness studies, Spirituality constructs (Love, hope, faith, joy, etc.), Soul retrieval (see Indigenous practices), Spiritual healing, "Special" healers (see "Biofield").
C15714	Basic_Science	Research	Basic Science|Basic Research	Research aimed at deriving general knowledge, without a direct application toward solving a specific problem.
C15715	Applied_Research	Research	Applied Research|Applied Science	Research directed toward solving a specific problem (as opposed to Basic Research).
C15716	Population_Study	Research	Population Study	Multidisciplinary study done at the population level or among the population groups, generally to find the cause, incidence or spread of the disease or to see the response to the treatment, nutrition or environment.
C15717	Cytogenetic_Map	Physical_Map_of_the_Human_Genome	Cytogenetic Map	The visual appearance of a chromosome when stained and examined under a microscope. Particularly important are visually distinct regions, called light and dark bands, which give each of the chromosomes a unique appearance. This feature allows a person's chromosomes to be studied in a clinical test known as a karyotype, which allows scientists to look for chromosomal alterations. (NHGRI Glossary of Genetic Terms)
C15718	Homeopathic_Remedy	Treatment_Regimen	Homeopathic Remedy|Homeopathy|homeopathic remedies	Small doses of medicines, herbs, or both that are believed to stimulate the immune system.
C15719	Surveillance	Observational_Study	Surveillance|Epidemiology / Surveillance	The systematic collection, analysis, and interpretation of health data on an ongoing basis.
C15720	Pharmacodynamics	Pharmacology	Pharmacodynamics	The study of the biochemical and physiological effects of drugs and the mechanisms of their actions, including the correlation of actions and effects of drugs with their chemical structure, also, such effects on the actions of a particular drug or drugs.
C15721	Epidemiology_Research	Research	Epidemiology Research|Epidemiologic Research|Epidemiological Studies	The study of factors determining and influencing the frequency and distribution of disease, injury, and other health related events and their causes in a defined human population. (CSP2000)
C15722	Patient_Observation	Treatment	Patient Observation|Observation|Watchful Waiting|observation|watchful waiting	The most conservative option for patient under the control of medical professional. The concept refers to the situation when patient's condition is closely monitored under assigned "precaution" level, but treatment is withheld until signs or symptoms of the disease appear or change.
C15723	Bypass	Surgical_Procedure	Bypass|bypass	A surgical procedure in which the doctor creates a new pathway for the flow of body fluids.
C15724	Inguinal_Orchiectomy	Orchiectomy	Inguinal Orchiectomy|inguinal orchiectomy	(IN-gwin-al or-kee-EK-toe-mee) An operation in which the testicle is removed through an incision in the groin.
C15725	Laparoscopic_Surgery	Surgical_Procedure	Laparoscopic Surgery|laparoscopy-assisted surgery
C15726	Thoracoscopic_Surgery	Thoracic_Surgical_Procedures	Thoracoscopic Surgery
C15727	cDNA_Library	Library	cDNA Library|Library	A collection of DNA molecules that have been cloned in vectors.  In the case of a cDNA library the DNA inserts are copies of RNAs that have been reverse-transcribed into DNA prior to cloning.
C15728	Reiki	Complementary_and_Alternative_Medicine	Reiki	An alternative medical practice.  The practitioners of reiki believe that health and disease are a matter of the life force being disrupted.  Reiki healers claim to channel reiki into "diseased" individuals for "rebalancing." (from Skeptic's Dictionary)
C15729	Sequential_Treatment	Treatment	Sequential Treatment|sequential treatment	One treatment after the other.
C15730	Peritoneal_Perfusion	Intraperitoneal_Therapy|Perfusion	Peritoneal Perfusion|peritoneal perfusion	A method of delivering fluids and drugs directly to tumors in the peritoneal cavity.
C15731	Intrahepatic_Infusion	Intrahepatic_Route_of_Drug_Administration	Intrahepatic Infusion|IHI|intrahepatic infusion	Administration of a fluid form of the drug via a blood vessel into the liver over the sustained period of time.
C15732	Continuous_Hyperthermic_Peritoneal_Perfusion	Hyperthermic_Perfusion|Peritoneal_Perfusion	Continuous Hyperthermic Peritoneal Perfusion|CHPP|continuous hyperthermic peritoneal perfusion	CHPP. A procedure that bathes the abdominal cavity in fluid that contains anticancer drugs. This fluid is warmer than body temperature. This procedure appears to kill cancer cells without harming normal cells.
C15733	Diagnostic_Trial	Clinical_Trials_Diagnosis	Diagnostic Trial|diagnostic trial	A research study that evaluates methods of detecting disease.
C15734	Prevention_of_Gastric_Cancer	Cancer_Prevention	Prevention of Gastric Cancer
C15735	Prevention_of_Bladder_Cancer	Cancer_Prevention	Prevention of Bladder Cancer
C15736	Intracarotid_Infusion	Infusion_Technique	Intracarotid Infusion|intracarotid infusion	The introduction of fluids and drugs directly into the carotid artery, the main artery in the neck that carries blood from the heart to the brain.
C15737	Intraventricular_Infusion	Infusion_Technique	Intraventricular Infusion|intraventricular infusion	The delivery of a drug into a space within an organ.
C15738	Dyspnea_Management	Palliative_Other_Than_Pain_and_Hospice	Dyspnea Management|management of dyspnea	Treatment to manage or alleviate difficult or painful breathing or shortness of breath.
C15739	Immunotoxin_Therapy	Antibody_Conjugate_Therapy	Immunotoxin Therapy
C15740	Menopausal_Symptoms_Attenuation	Supportive_Care	Menopausal Symptoms Attenuation	Therapy to reduce the effects of menopausal symptoms.  May also be necessary in order to counteract the effect of various chemotherapy treatments.
C15741	Screening_for_Hepatocellular_Cancer	Cancer_Screening	Screening for Hepatocellular Cancer|hepatocellular cancer, screening for|liver cancer, screening for|screening for liver cancer
C15742	Postremission_Therapy	Chemotherapy	Postremission Therapy|Post Remission Therapy|postremission therapy	Anticancer drugs given to kill cancer cells that survive after remission induction therapy.
C15743	Medical_Castration	Hormone_Therapy	Medical Castration|medical castration	Refers to the use of drugs to suppress the function of the ovaries or testicles.
C15744	in_vivo	Drug_Development_Experimental	in vivo	In the body. The opposite of in vitro (outside the body or in the laboratory).
C15745	Hyperfractionation	Fractionation	Hyperfractionation|Hyperfractionated Radiation|hyperfractionation	A way of giving radiation therapy in smaller-than-usual doses two or three times a day instead of once a day.
C15746	Remission_Induction_Therapy	Chemotherapy	Remission Induction Therapy|remission induction therapy	The initial chemotherapy a person receives to bring about a remission.
C15747	Supportive_Care	Treatment	Supportive Care|Supportive Therapy|Symptom Management|Therapy, Supportive|supportive care	Supportive care is that which helps the patient and their family to cope with cancer and treatment of it from pre-diagnosis, through the process of diagnosis and treatment, to cure, continuing illness or death and into bereavement. It helps the patient to maximize the benefits of treatment and to live as well as possible with the effects of the disease. Supportive therapy may provide a patient with friendship, encouragement, practical advice such as access to community resources or how to develop a more active social life, vocational counseling, suggestions for minimizing friction with family members, and, above all, hope that the life of the patient may be improved. In all situations, supportive therapy involves the teaching of such life skills as managing medication, learning to socialize, handling finances, and getting a job.
C15748	Total_Nodal_Irradiation	Extensive_Radiation|Prior_Extensive_Radiation	Total Nodal Irradiation|total nodal irradiation	Radiation therapy to the mantle field, the spleen, the lymph nodes in the upper abdomen, and the lymph nodes in the pelvic area.
C15749	Tumor_Debulking	Local_Therapy|Surgical_Procedure	Tumor Debulking|Debulking|tumor debulking	Surgically removing as much of the tumor as possible.
C15750	Intrathecal_Chemotherapy	Compartmental_Treatment|Regional_Chemotherapy	Intrathecal Chemotherapy|intrathecal chemotherapy	(in-tra-THEE-kal KEE-mo-THER-a-pee) Anticancer drugs that are injected into the fluid-filled space between the thin layers of tissue that cover the brain and spinal cord.
C15751	External_Beam_Radiation	Radiation_Therapy	External Beam Radiation Therapy|Definitive Radiation Therapy|EBRT|External Beam RT|External Radiation|external radiation|external-beam radiation	(ray-dee-AY-shun) Radiation therapy that uses a machine to aim high-energy rays at the cancer.
C15752	Chemoembolization	Chemotherapy|Embolization_Therapy	Chemoembolization|Chemotherapy Embolization|TACE|chemoembolization	A procedure in which the blood supply to the tumor is blocked surgically or mechanically and anticancer drugs are administered directly into the tumor. This permits a higher concentration of drug to be in contact with the tumor for a longer period of time.
C15753	Cancer_Registry	Population_Database	Cancer Registry	Cancer registries gather a wide variety of specific information on cancer patients that can be analyzed to identify health disparity trends in cancer incidence, mortality and patient survival.
C15754	Geographic_Information_System	Database	Geographic Information System|GIS	A GIS is an organized collection of computer hardware, software, geographic data and personnel designed to efficiently capture, store, update, manipulate, analyze and display all forms of geographically referenced information.  NCI's plan is to use geographic information systems for the assessment of environmental risk factors, identification of places and/or subpopulations where cancer surveillance and control programs are needed.  (from http://www.pitt.edu/~super1/lecture/lec1451/005.htm and http://newscenter.cancer.gov/pressreleases/gisqa.html)
C15755	Lumpectomy	Breast_Conservation_Treatment	Lumpectomy|Partial Mastectomy|lumpectomy|partial mastectomy	(lump-EK-toe-mee) Surgery to remove the tumor and a small amount of normal tissue around it.
C15756	Single_Agent_Systemic_Chemotherapy	Chemotherapy|Prior_Chemotherapy	Single Agent Systemic Chemotherapy|Chemotherapy Single Agent Systemic	Systemic chemotherapy with a single agent regimen.  A regimen is described as a distinctive collection of agent(s) and/or modalities to be utilized together during a cycle or course of therapy.  All routes of administration are acceptable as long as the agent is intended for systemic therapy.
C15757	Antiestrogen_Therapy	Hormone_Therapy	Antiestrogen Therapy
C15758	Central_Line_Management	Catheter_Management	Central Line Management|management of central line
C15759	Urostomy	Ostomy|Urologic_Surgical_Procedure	Urostomy|urostomy	(yoo-RAHS-toe-mee) An operation to create an opening from inside the body to the outside, making a new way to pass urine.
C15760	Drug_Development	Research	Drug Development	Design, identification, synthesis, extraction, purification, modification, or characterization of potential anticancer agents; studies of their metabolism, distribution, excretion, physiological effects, molecular interactions, structural analysis, toxicity, mechanism of action, antitumor effects in vivo (nonhuman species) or in vitro (human or nonhuman), and phase I and phase II clinical trials.
C15761	Acustimulation	Acupuncture	Acustimulation|acustimulation	Mild electrical stimulation of acupuncture points to control symptoms such as nausea and vomiting.
C15762	Laparoscopic_Colectomy	Colectomy|Laparoscopic_Surgery	Laparoscopic Colectomy|Laparoscopic-Assisted Colectomy|Laparoscopy-Assisted Colectomy|laparoscopic-assisted colectomy	Surgery done with the aid of a laparoscope (a thin, lighted tube) to remove part or all of the colon through small incisions made in the wall of the abdomen.
C15763	Advanced_Manufacturing_Technology	Technology_Development	Advanced Manufacturing Technology	The focus is on the manufacturing process, not on the product. Includes research and development efforts leading to new or improved manufacturing processes, equipment, or techniques; also related activities to manage and deploy manufacturing technologies.
C15764	AIDS_Clinical_Trial-AIDS-Related_Malignancie	Clinical_Trial	AIDS, Clinical Trials-AIDS-Related Malignancy	Clinical Trials with a minimum of 20% (or $100,000) relevance to the development of vaccines and therapeutics directed against AIDS-related malignancies. To include: Kaposi's sarcoma, Non-Hodgkins lymphoma, Other lymphomas, Lymphosarcomas
C15765	AIDS_Clinical_Trials-Minority	Clinical_Trial	AIDS, Clinical Trials-Minority	Clinical trials with a minimum of 20% (or $100,000) relevance to individuals of non-Caucasian descent, and individuals of Hispanic descent.
C15766	AIDS_Clinical_Trial-Opportunistic_Infection	Clinical_Trial	AIDS, Clinical Trials-Opportunistic Infection	Clinical Trials with a minimum of 20% (or $100,000)relevance to the development of vaccines and therapeutics directed against opportunistic infections associated with HIV infection. To include: Pneumocystosis, toxoplasmosis, cryptosporidiosis, candidiasis, cryptococcosis, mycobacteriosis, cytomegalovirus, papillomavirus, herpes simplex, JC virus, coccidioides, hairy leukoplakia, and HIV-related periodontal disease.
C15767	AIDS_Clinical_Trials-Pediatric	Clinical_Trial	AIDS, Clinical Trials-Pediatric	Clinical Trials with a minimum of 20% (or $100,000) relevance to children 0-18 years of age. To include: Pregnant females, Neonates, Infants
C15768	AIDS_Clinical_Trials-Women	Clinical_Trial	AIDS, Clinical Trials-Women	Clinical Trials with a minimum of 20% (or $100,000) relevance to females 12 years of age or older. To include: Pregnant women, Women at risk of AIDS, Female prostitutes, Perinatal transmission of HIV.
C15769	Basic_Behavioral_and_Social_Science_Research	Behavioral_Research	Basic Behavioral and Social Science Research	Support basic social sciences and behavioral research to strengthen the understanding of (a) determinants and processes that influence HIV-related risk behaviors and (b) the consequences of HIV disease.
C15770	Behavior_Research_Direct	Behavioral_Research	Behavior Research, Direct	Research on people's behavior in the context of cancer; how people's behavior affects their chance of developing cancer
C15771	Behavior_Research_Indirect	Behavioral_Research	Behavior Research, Indirect	Research on any factor or condition, exposure to which is theoretically susceptible to behavioral modification, but in which no actual behavioral work is being done (e.g., experimental studies on tobacco, dietary components, many other environmental carcinogens).
C15772	Biological_Response_Modifiers_Program	Cancer_Research_Project	Biological Response Modifiers Program|BRMP	A program set up to establish cooperative agreements for Clinical Trials of Cancer Therapy with Biological Response Modifiers (CATBRMs), for the development of novel approaches to such therapy.  Funding to foster innovative clinical trials of BRMs by peer-reviewed groups of highly experienced clinical and preclinical investigators who have the unique technical capabilities to study new agents in early clinical trials and to address hypothesis-driven issues of mechanisms of action.  (from Clinical Trials Of Cancer Therapy With Biological Response Modifiers, RFA: CA-92-28)
C15773	Blood_Banking_Leukocyte	Repository_Operations	Leukocyte Banking|Blood Banking, Leukocyte	The typing, separation, and storage of leukocytes for transfusion to recipients.
C15774	Breast_Cancer_Treatment	Cancer_Treatment	Breast Cancer Treatment|Breast Cancer, Treatment	Medical or surgical interventions to eradicate breast tumors and/or their metastases.
C15775	Breast_Cancer_Detection	Basic_Cancer_Research	Breast Cancer Detection Research|Breast Cancer Detection	Research project involving detection of breast tumors (screening, diagnosis clinical trials), development or refinement of diagnostic techniques or devices, education or promotion of breast cancer detection.
C15776	Cancer_Detection	Detection	Cancer Detection	The act of discovery of a malignant neoplasm, and after treatment, the discovery of minimal residual disease.
C15777	Cancer_Prevention_Primary	Cancer_Prevention|Primary_Prevention	Cancer Prevention, Primary	NIH Emphasis Area -- The term "prevention" refers to prophylactic and preventative efforts to achieve a significant reduction in cancer incidence, cancer mortality, and cancer morbidity. "Primary prevention" involves efforts to directly prevent and/or inhibit malignant transformation; to identify, characterize, and manipulate factors that might be effective in achieving that inhibition; and attempts to promote preventative measures, such as appropriate training of scientists and clinicians. Prevention and intervention efforts are biologic activities aimed at the cell - at the genetic and cellular changes that result in the transformation process and that define cancer development
C15778	Cancer_Prevention_Secondary	Cancer_Prevention|Secondary_Prevention	Cancer Prevention, Secondary
C15779	Carcinogen_Screening	Biomedical_Research	Carcinogen Screening|Carcinogenesis, Screening	In vitro or in vivo testing to give a quantitative measure of tumor-inducing potency of the substance.
C15780	Carcinogenesis_Inhibition	Cancer_Prevention	Carcinogenesis Inhibition|Carcinogenesis, Inhibition	Suppression or prevention of the carcinogenic process/development of cancer.
C15781	Carcinogenesis_Reversion	Cancer_Treatment	Carcinogenesis Reversion|Carcinogenesis, Reversion
C15782	Chemoprevention_Clinical	Chemoprevention	Clinical Chemoprevention|Chemoprevention, Clinical	Chemoprevention use in a clinical setting.
C15783	Clinical_Data	Data	Clinical Data	Data obtained through patient examination or treatment.
C15784	Clinical_Nutrition	Nutritional_Study	Clinical Nutrition	An area of medicine that seeks to identify and treat medical disorders in humans that result from improper or inadequate diet, or from diseases that make the body unable to handle the nutrients delivered to it in the normal diet. The usual treatment is dietary, but can be the delivery of nutrients by other means. (from University of Pittsburgh Medical Center glossary)
C15785	Clinical_Services	Healthcare_Activity	Clinical Services|Services
C15786	Clinical_Treatment	Treatment	Clinical Treatment	Actual observation and treatment of disease in patients (including experimental treatment) as distinct from theoretical or experimental work.
C15787	Clinical_Trial_Design	Healthcare_Activity	Clinical Trials Design	The detailed planning of studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects.
C15788	Clinical_Trials_Diagnosis	Clinical_Trial	Clinical Trials, Diagnosis	Clinical evaluation of the utility of diagnostic procedures.
C15789	Clinical_Trials_Monitoring	Healthcare_Activity	Clinical Trials, Monitoring	For clinical decision-making, the purposeful and ongoing acquisition, interpretation, and synthesis of patient data obtained from clinical trials.
C15790	Cancer_Prevention_Trial	Clinical_Trial	Cancer Prevention Trial|Clinical Trials, Prevention	Clinical trials that study ways of reducing the risk of getting cancer.
C15791	Clinical_Testing	Testing	Clinical Testing|Clinical Evaluation	Small-scale testing (usually on SBIRs) of new technology in a small group of patients or normal volunteers. Does not meet the rigorous criteria of a clinical trial.
C15792	Transplantation_and_Immune_System	Transplantation	Transplantation and Immune System|Clinical, Transplantation, Immune System	The interaction of a recipient's (patient's) immune system with an organ or tissue graft, or with the reactivity of donor-derived passenger leukocytes in the graft with the host's (patient's) body. (NCI/OSP)
C15793	Conduct_Clinical_Trials	Healthcare_Activity	Conduct Clinical Trials	Conduct clinical trials and develop new trial methodologies for the treatment of HIV infection. Trials should be designed in order to rapidly develop new therapeutic strategies, optimize clinical efficacy and proper use of available modalities, define factors that affect the success of therapeutic strategies (including the role of resistance), and advance our understanding of disease pathogenesis and progression.
C15794	Cancer_Therapy_Evaluation_Program	Professional_Organization_or_Group	Cancer Therapy Evaluation Program|CTEP	The program within the Division of Cancer Treatment and Diagnosis (DCTD) of the NCI which plans, assesses, and coordinates all aspects of clinical trials including extramural clinical research programs, internal resources, treatment methods and effectiveness, and compilation and exchange of data as it pertains to the development and evaluation of anticancer agents.
C15795	Detection_of_Minimal_Residual_Disease	Detection	Detection of Minimal Residual Disease	The discovery of a tumor or cancer after primary, potentially curative therapy.
C15796	Developmental_Diagnostic	General_Modifier	Developmental Diagnostic	Refers to diagnostic methods for evaluating developmental problems.
C15797	Diagnostic_Methods_and_Reagents	Diagnostics_Research	Diagnostic Methods and Reagents	1A4; Basic Science Research (includes vaccine and chemotherapy development), Biomedical Research
C15798	Diagnostics_Research	Applied_Research|Clinical_Study	Diagnostics Research
C15799	Diagnostics_Cancer	Diagnostic_Reagents_and_Test_Kits	Diagnostics, Cancer	Reagents and techniques used for the diagnosis of cancer.
C15800	Drug_Development_Clinical	Drug_Development	Drug Development, Clinical|Drug Testing/Development, Clinical
C15801	Drug_Development_Preclinical	Drug_Development	Drug Development, Preclinical|Drug Testing/Development, Preclinical
C15802	Drug_Discovery	Research	Drug Discovery
C15803	Drug_Discovery_Groups	Cancer_Research_Project	Drug Discovery Groups	Self-identified projects in the Biochemistry and Pharmacology Cancer Activity.
C15804	EPS_Library	Information_Resources	EPS Library|EPS Library (DCPC Plus DCEG)	Library located at Executive Plaza South.
C15805	Experimental_Nutrition	Nutritional_Study	Experimental Nutrition
C15806	Health_and_Behavior_in_Children	Child_Health|Health_and_Behavior	Health and Behavior in Children
C15807	High_Dose_Chemotherapy	Chemotherapy	High Dose Chemotherapy
C15808	Intercept_Vertical_Transmission-Perinatal_Transmission_of_HIV	Preventive_Intervention	Intercept Vertical Transmission-Perinatal Transmission of HIV	Develop, evaluate, and implement strategies for interrupting vertical transmission of HIV from mother to child and extend our understanding of perinatal transmission and the pathogenesis of early infection (treatment of children will be addressed in other objectives). (Note: The OAR Coordinating Committee on Therapeutics feels scientific objectives 3E through 3G are of equal weight in terms of scientific priorities.)
C15809	Laboratory_Animal_Production_and_Facilities	Core_Facility	Laboratory Animal Production and Facilities|Research Animal Facility	The production of laboratory animals for research
C15810	Laboratory_Correlate_Data	Clinical_Data	Laboratory/Correlate Data
C15811	Low_Dose_Radiation	Radiation_Therapy	Low Dose Radiation
C15812	Maternal_and_Child_Health	Population_Research	Maternal and Child Health	Studies focusing on the involvement of maternal factors (and efforts to modify these factors) that may affect the health of the child or fetus: smoking or exposure to drugs or toxic chemicals during pregnancy, maternal/fetal immunologic interactions.
C15813	Media_Intervention	Intervention	Media Intervention	An act or ministration that produces an effect to alter the course of a pathologic process through the use of a variety of media, i.e., CD-ROM, Web application, video, telephone.
C15814	Multicenter_Hemophilia_Cohort_Study	Cancer_Research_Project	Multicenter Hemophilia Cohort Study|MHCS
C15815	Monitoring_for_Recurrence	Surveillance	Monitoring for Recurrence
C15816	Natural_History_of_Progression_of_HIV-related_Diseases	Natural_History	Natural History of Progression of HIV-related Diseases	Elucidate the progression of HIV infection, from its earliest stages through long-term sequelae.
C15817	Neuroscience_and_Neuropsychiatric_Research	Basic_Science	Neuroscience and Neuropsychiatric Research	1B; Basic Science Research (includes vaccine and chemotherapy development), Neuroscience And Neuropsychiatric Research
C15818	National_Surgical_Adjuvant_Breast_and_Bowel_Project	Clinical_Trials_Cooperative_Group	National Surgical Adjuvant Breast and Bowel Project|NSABP	A clinical trials cooperative group supported by the NCI. The group headquarters in Pittsburgh, Pennsylvania and has research sites at nearly 200 major medical centers, university hospitals, large oncology practice groups, and health maintenance organizations in the United States, Canada, Puerto Rico, and Australia. In addition to funding from the NCI, which the NSABP has received since it began, the NSABP also receives support from other sources for ancillary studies, training, and educational programs.
C15819	Nucleic_Acid_Resources	Research_Resources	Nucleic Acid Resources
C15820	Nutritional_Study	Clinical_Study	Nutritional Study|Nutrition|Nutrition Research	Research that focuses on food, the nutrients and other substances contained therein, their action, interaction, and balance in relation to health and disease.
C15821	Nutrition_Research_Applied_Clinical_Trials	Applied_Research	Nutrition Research, Applied Clinical Trials
C15822	Nutrition_Research_Applied_Non-Clinical_Trials	Applied_Research	Nutrition Research, Applied Non-Clinical Trials
C15823	Nutrition_Research_Basic_Non-Clinical_Trials	Basic_Science	Nutrition Research, Basic Non-Clinical Trials
C15824	Nutrition_Dietary_Components	Nutritional_Study	Nutrition, Dietary Components	Role of dietary components in cancer causation or prevention and in general health.
C15825	Nutrition_Fats_Saturated	Nutrition_Fats	Nutrition, Fats, Saturated|Lipid Nutrition, Saturated	Role of saturated fats in cancer causation or prevention and in general health.
C15826	Nutritional_Anthropometry	Nutritional_Study	Nutritional Anthropometry	The study of nutritional effects upon size, weight, and proportions of the human or other primate body.
C15827	Nutritional_Biochemistry	Nutritional_Study	Nutritional Biochemistry	The study of the biochemistry of foods and vitamins as they affect the body
C15828	Other_Resources	Research_Resources	Other Resources	Resources (facilities, collections, software, information sources, etc.) available to researchers that are not listed in other concepts of Research Resources tree of NCI Metathesaurus.
C15829	Outcomes_and_Health_Services_Research	Clinical_Study	Outcomes and Health Services Research
C15830	Palliative_Other_Than_Pain_and_Hospice	Palliative_Care	Palliative Other Than Pain and Hospice	Supportive care that is not hospice or pain relief
C15831	Pathobiology_of_Wasting_and_Growth_Retardation	Translational_Research	Pathobiology of Wasting and Growth Retardation	Elucidate the pathogenic mechanisms of HIV-related opportunistic infections. Enhance a bidirectional flow between basic and clinical observations and intervention programs on HIV-related complications and foster interdisciplinary collaborations.
C15832	Patient_Oriented_Research	Research	Patient Oriented Research	Studies of living individuals or groups of subjects (such as families, communities, or populations defined geographically or demographically), or material of human origin (such as tissues, specimens, and cognitive phenomena, etc.), for understanding of their physiologic and pathophysiologic characteristics, mechanisms of human diseases and development of approaches to diseases treatment and prevention. Includes the laboratory-based development of new forms of technology, studies of health-related professions, institutions, and systems, excludes disease-oriented studies of material, obtained from patients who were unknown to investigators.
C15833	Pediatric_Clinic_and_Service	Clinical_Services	Pediatric Clinics and Services
C15834	Pharmaceutical_Resources	Research_Resources	Pharmaceutical Resources	A collection of pharmaceutical substances available for research use
C15835	Phase_I_and_II_Vaccine_Trials	Vaccine_Clinical_Trial	Phase I and II Vaccine Trials	Select candidate vaccines or concepts suitable for Phase I and Phase II trials and conduct these trials.
C15836	Prostate_Lung_Colorectal_and_Ovarian_Cancer_Screening_Trial	Cancer_Research_Project	Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial|PLCO	The Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, or PLCO Trial, is a large-scale study to determine if certain tests will reduce the number of deaths from these cancers.  Sponsored by the National Cancer Institute (NCI), the study will involve 148,000 men and women ages 55 through 74 at medical facilities in 9 geographic areas across the United States.  (Cancer Facts Screening: Questions and Answers About the PLCO Cancer Screening Trial)
C15837	Population_Intervention	Intervention	Population Intervention
C15838	Prevent_Transmission_of_HIV_Safety_Blood_Supply	Preventive_Intervention	Prevent Transmission of HIV/Safety Blood Supply	Develop and assess multiple and concurrent ethical intervention strategies to reduce or prevent HIV transmission in both domestic and international settings.
C15839	Prevention_and_Treatment_Evaluation	Therapy_Evaluation	Prevention and Treatment Evaluation
C15840	Prevention_and_Treatment_of_Opportunistic_Infection	Prevention	Prevention and Treatment of Opportunistic Infection	Improve understanding of the biology of opportunistic pathogens, identify potential molecular targets for effective therapies, and discover and delineate the structure and function of potential agents for prevention and treatment of HIV-associated OIs and other infections that are modified by HIV infection.
C15841	Prevention_of_High-Risk_Behaviors	Behavioral_Intervention|Prevention	Prevention of High-Risk Behavior	1C2; Basic Sciences Research (includes vaccine and chemotherapy development); Behavioral Research; Prevention of high-risk behaviors (behavioral and pharmacologic interventions)
C15842	Prevention_Early_Detection_of_Premalignant_Lesions	Early_Detection	Prevention, Early Detection of Premalignant Lesions
C15843	Preventive_Intervention	Intervention	Preventive Intervention	Therapeutic, nutritional, environmental, social and or behavioral interventions at the societal, community, organizational or individual levels to reduce, modify or stop the course of a disease.
C15844	Protein_Amino_Acid_Nutrition_Animal	Nutrition_Protein_Amino_Acids	Protein/Amino Acid Nutrition, Animal	Study of dietary animal protein/amino acids in relation to cancer.
C15845	Protein_Amino_Acid_Nutrition_Non-Animal	Nutrition_Protein_Amino_Acids	Protein/Amino Acid Nutrition, Non-Animal	Study of dietary non-animal protein/amino acids in relation to cancer.
C15846	Radiation_Ionizing_Radiotherapy	Local_Therapy|Radiation_Therapy	Radiation Ionizing Radiotherapy|RADIATION|RT	The use of ionizing radiation to kill cancer cells
C15847	Radiation_Non-Ionizing_Radiotherapy	Local_Therapy|Radiation_Therapy	Radiation Non-Ionizing, Radiotherapy
C15848	Radiology_Treatment_Planning	Healthcare_Activity	Radiology, Treatment Planning
C15849	Radiotherapy_High_Linear_Energy_Transfer	Local_Therapy|Radiation_Therapy	High-LET Radiotherapy|Radiotherapy, High Linear Energy Transfer|Radiotherapy-High LET	Radiotherapy using radioactive particles that deposit a high amount of energy by radiation per unit length of travel.
C15850	Radiotherapy_Low_Linear_Energy_Transfer	Local_Therapy|Radiation_Therapy	Low-LET Radiotherapy|Radiotherapy, Low LET|Radiotherapy, Low Linear Energy Transfer	Radiotherapy using radioactive particles that deposit a low amount of energy by radiation per unit length of travel.
C15851	Redirected_Cytolysis	Immunotherapy	Redirected Cytolysis|Redirected Cytotoxicity	The killing of target cells by changing the natural specificity of cytotoxic T cells by the use of an antibody or other molecule capable of binding to both the T cell and to the target cell.  Often involves hybrid (bispecific) antibodies having distinct specificities for the T cell and for the target cell. (NCI/OSP)
C15852	Repository_Operations_Other	Repository_Operations	Repository Operations, Other
C15853	Repository_Operations_Sera	Repository_Operations	Repository Operations, Sera|Culturing, in vitro Repository Operations, Serum
C15854	Social_Health_Services	Clinical_Services	Social Health Services
C15855	State_Cancer_Legislative_Database	Database	State Cancer Legislative Database	The SCLD maintains information about state legislation and regulation addressing cancer-related topics, including tobacco, breast cancer, genetics, cervical cancer, prostate cancer, testicular cancer, colon cancer, ovarian cancer, access to state-of-the-art cancer treatment, cancer registries, and selected issues related to diet and nutrition, employment discrimination, environmental exposure, and occupational exposure.  The purpose of the SCLD is threefold; it provides necessary information: 1) for evaluating the effect of state legislation on public health and on the application of cancer control science, 2) for facilitating the application of cancer control science, and 3) for monitoring legislative trends that may reflect changing public attitudes and practices. (State Cancer Legislative Database Program)
C15856	Clinical_Trials_Therapy	Clinical_Trial	Clinical Trials, Therapy|Therapeutic Trials	A clinical trial that studies interventions to rate the relative effectiveness of methods designed to find better ways to prevent, detect, diagnose, or treat cancer.
C15857	Therapy_Evaluation	Clinical_Testing	Therapy Evaluation	Determining the efficacy of a particular therapy or treatment
C15858	Tissue_Resources	Research_Resources	Tissue Resources
C15859	Trace_Element_Nutrition_Fluorides	Nutrition_Trace_Elements	Trace Element Nutrition, Fluorides	Studies of the role of the trace element fluoride, obtained through diet, on general health
C15860	Trace_Element_Nutrition_Mercury	Nutrition_Trace_Elements	Trace Element Nutrition, Mercury	Studies of the role of the trace element mercury, obtained through diet, on general health
C15861	Trace_Element_Nutrition_Other	Nutrition_Trace_Elements	Trace Element Nutrition, Other
C15862	Translational_Research	Research	Translational Research|Translational Research Enterprise|Translational Science	Translational research requires interdependence between basic and clinical investigators in both the planning and implementation of research and emphasizes clinical application of basic research findings with patients and populations. Translational research also applies clinical findings to advance basic research that ultimately may lead to hypothesis-driven clinical trials or prevention and control interventions (from Specialized Programs Of Research Excellence In Prostrate Cancer NIH Guide, Volume 23, Number 33, September 16, 1994, RFA: CA-94-031)
C15863	Tumor_Bank	Tissue_Collection	Cancer Biobank|Cancer Biorepository|Tumor Bank	A repository of biospecimens - including tissue samples, fluids such as blood, serum and urine, and molecular derivatives such as DNA, RNA and proteins pertaining to cancer research. The repository has stringent guidelines regarding the standardized collection, handling, storage and documentation of biological specimens. These guidelines enable an extensive system for specimen storage that allows for the accurate establishment of disease incidences over long periods of time.
C15864	Vaccine_Clinical_Trial	Clinical_Trial	Vaccine Clinical Trial
C15865	Vaccine_Design_and_Animal_Testing	Vaccine_Development	Vaccine Design and Animal Testing	Apply findings from basic, epidemiologic, and clinical research to the design and evaluation of vaccine strategies in laboratory studies and animal models, and foster collaboration with industry in the research and development of candidate vaccines.
C15866	Vaccine_Development_AIDS	Vaccine_Development	Vaccine Development, AIDS	Vaccines or candidate vaccines containing inactivated HIV or some of its component antigens and designed to prevent AIDS. Some vaccines containing antigens are recombinantly produced.
C15867	Vaccine_Development_Other_Non-AIDS	Vaccine_Development	Vaccine Development, Other Non-AIDS
C15868	Vaccine_Related_Development_AIDS	Vaccine_Development	Vaccine Related Development, AIDS
C15869	Vaccine_Related_Development_Cancer	Vaccine_Development	Vaccine Related Development, Cancer
C15870	Vaccine_Related_Development_Non-Cancer_Non-AIDS	Vaccine_Development	Vaccine Related Development, Non-Cancer; Non-AIDS
C15871	Vaccine_Related_Non-Development_AIDS	Vaccine_Development	Vaccine Related Non-Development, AIDS
C15872	Vaccine_Related_Non-Development_Non-AIDS	Vaccine_Development	Vaccine Related Non-Development, Non-AIDS
C15873	Vaccine_Trial-Phase_III_Large_Scale	Vaccine_Clinical_Trial	Phase III Large Scale Vaccine Trial|Vaccine Trial-Phase III Large Scale	Select suitable vaccine candidates and support efficacy trials when appropriate criteria are met.
C15874	Validation_of_Clinical_Utility_of_Markers	Validation	Validation of Clinical Utility of Markers
C15875	Validation_of_Technology	Validation	Validation of Technology
C15876	Virus_Cancer_Research	Cancer_Research_Project	Virus Cancer Research	Experimental or epidemiological studies of viruses as carcinogens or co-carcinogens.
C15877	Worksite_Health_Services	Community_Health_Services	Worksite Health Services	Clinical services at the physical site of employment.
C15878	Population_Research	Population_Study	Population Research	Research on fertility, contraceptives, transplacental carcinogenesis or other in utero or pre-conception disease induction.
C15879	Infrastructure_Activities	NIH_Emphasis_Area	Infrastructure Activities	NIH Emphasis Area: Infrastructure activities are new or expanded programs in the following: Research Training; Shared Instrumentation and Services; Technology Development; Information Technology and Clinical Research. Again, only new or expanded program initiatives should be reported-e.g., an increase in training related only to the increase in stipends should not be reported as an Infrastructure Initiative.
C15880	Biology_of_the_Brain_Disorders	NIH_Emphasis_Area|Neuroscience_and_Neuropsychiatric_Research	Biology of the Brain Disorders	NIH Emphasis Area -- New emphasis on the biology of brain disorders reflects the extraordinary rate at which the neurosciences, with strong support from the fields of molecular genetics, imaging, and cell biology, is growing.  Efforts in neural development; neurodegeneration, especially in Alzheimer's disease, Parkinson's disease, mental illness and traumatic injury to the brain and spinal cord are few examples of the promise of this field.
C15881	New_Approach_to_Pathogenesis	NIH_Emphasis_Area	New Approaches to Pathogenesis	NIH Emphasis Area -- Innovative approaches to pathogenesis, resulting from more precise understanding of genes, proteins, and cells, are transforming traditional descriptions of disease processes.  For example, research in this arena will uncover new mechanisms of carcinogenesis and cardiovascular disease and will lead to better understanding of osteoarthritis, birth defects and growth disorders.  These new insights into pathogenesis are, in turn, stimulating new preventive strategies against disease such as the development of new vaccines against a variety of pathogens.
C15882	New_Prevention_Strategy_Against_Disease	NIH_Emphasis_Area	New Prevention Strategies Against Disease	NIH Emphasis Area: Research in new procedures and approaches to prevent disease.
C15883	New_Avenue_for_the_Development_of_Therapeutics	NIH_Emphasis_Area	New Avenues for the Development of Therapeutics	NIH Emphasis Area -- The result of efforts in chemistry, structural biology, genetics, and cellular and molecular biology are providing new means to design therapies for a variety of diseases.  Efforts to discover and develop drugs to combat cancer and drug and alcohol addiction and methods of bioengineering to repair tissues are ripe for discovery.
C15884	Computers_and_Advanced_Instrumentation	NIH_Emphasis_Area	Computers and Advanced Instrumentation	NIH Emphasis Area -- Recent advances in basic biology, genetics, diagnosis, and health care have all been closely linked to the development of new research instruments and computer hardware and software.  Improvements in the detection of early cancers and technologies to better visualize the living body in health and disease states will provide a wealth of knowledge that can lead to new and improved diagnostics, treatments and prevention strategies.
C15885	Mind-Body_System	Complementary_and_Alternative_Medicine	Mind-Body System	NIH: This area (subcategory of CAM) involves whole systems of mind-body practice that are used largely as primary interventions for disease.  They are rarely delivered alone but usually are in combination with lifestyle interventions or part of a traditional medical systems.  To be placed in this class the project should include the evaluation of a combination of at least three of the "mind-body methods" listed below (I b) and be used as a major adjunct to "standard care" or as an alternative to standard care without such components.
C15886	Mind-Body_Method	Mind-Body_System	Mind-Body Method|Mind/Body Research	This sub-category of CAM contains numerous specific modalities used in mind-body approaches to health.  Examples are meditation, hypnosis, biofeedback, support groups, etc.  These are often considered conventional practice and become CAM related when applied to conditions for which they are not usually used, such as hypnosis for genetic problems, support groups for cancer survival, meditation to slow aging.  Included are: Psychotherapy, Meditation, Imagery, Hypnosis, Biofeedback, Support groups, Art therapy, Music therapy, Dance therapy, Journalizing, Humor, Body Psychotherapy, Yoga, Qi Gong, and Tai Chi.
C15887	Social_and_Contextual_Areas_of_Mind_Body_Medicine	Mind-Body_Intervention	Social and Contextual Areas of Mind Body Medicine	NIH: Subcategory of Mind-Body Medicine in CAM classification.  This area deals with social, cultural, symbolic and contextual interventions not covered in other areas.  For example, the study cross-cultural explanatory models, placebo or "meaning response" research, and caring-based approaches to health care fall into this category.  Included are: Placebo, Explanatory models, Caring-based approaches, Community- based approaches, Intuitive diagnosis.
C15888	Alternative_Medical_System	Complementary_and_Alternative_Medicine	Alternative Medical System	NIH: Major category of Complementary and Alternative Medicine classification.  This category involves complete systems of theory and practice that are alternatives to the Western biomedical approach.  Includes: Acupuncture and oriental medicine; Traditional Indigenous Systems; Unconventional Western systems; and Naturopathy.
C15889	Traditional_Indigenous_Systems	Alternative_Medical_System	Traditional Indigenous System	Subcategory of Alternative Medical Systems in CAM. This sub-category refers to major indigenous systems of medicine other than acupuncture and traditional oriental medicine. It includes systems such as Ayurvedic medicine, Native American Medicine, Unani-Tibbi, Kampo, Traditional African systems and community based traditional medical systems. This sub-category may become subdivided further as these systems become better studied and more familiar in the U.S. Included are: Native American Medicine, Ayurvedic Medicine, Unani-Tibbi, SADHU, Kampo Medicine, Traditional African Medicine, Traditional Aboriginal Medicine, Curandersimo, Central and South American practices, Psychic surgery.
C15890	Unconventional_Western_System	Alternative_Medical_System	Unconventional Western System	NIH: Subcategory of alternative medical systems in CAM.  This sub-category deals with alternative medical systems developed in the West that are not dealt with elsewhere.  This includes systems such as homeopathy, Anthroposophically- extended Medicine, Environmental Medicine, Functional Medicine, Radionics, Cayce-based therapies, etc.  Included are: Homeopathy, Environmental Medicine, Functional Medicine, Anthroposophically-extended medicine, Radionics, Radiesthesia, Psionic medicine, Cayce-based systems.
C15891	Social_Aspects_of_Cancer	Clinical_Study	Social Aspects of Cancer|Psychosocial Influences|Psychosocial Issues	Influence of social factors, such as community, policy, and legislation on cancer control and outcomes
C15892	Evaluation_of_Risk_Factors	Healthcare_Activity	Evaluation of Risk Factors
C15893	Cell_Bank	Repository_of_Specimens_and_Reagents	Cell Bank	Repository of cell samples
C15894	Technique_Development	Research_Activity	Technique Development	Develop and evaluate new laboratory assays, behavioral methods, and statistical techniques for epidemiologic studies. (FMB)
C15895	Use_of_New_Techniques	Technique_Development	Use of New Techniques
C15896	Core_Facility	Clinical_or_Research_Facility	Core Facility	Shared facilities which provide services of a particular area of expertise
C15897	Cancer_Causation_Research	Research	Cancer Causation Research|Causation Research	Cancer causation research studies the events involved in the initiation and promotion of cancer. It encompasses chemical and physical carcinogenesis, biological carcinogenesis, epidemiology, chemoprevention, and nutrition research. Studies focus on external agents such as chemicals, radiation, fibers and other particles, viruses, parasitic infections, and host factors such as hormone levels, nutritional and immunologic status, and the genetic endowment of the individual, all of which contribute to the initiation and promotion of cancer.
C15898	Lifestyle_and_Disease_Prevention	Complementary_and_Alternative_Medicine	Lifestyle and Disease Prevention|Lifestyle and Disease Prevention (with ODP)	NIH: Major category of Complementary and Alternative Medicine. This category deals with theories and practices designed to prevent the development of illness, identify and treat risk factors, or support of healing and recovery processes.  It is concerned with integrated approaches for the prevention and management of chronic disease-in-general (DIG) or the common determinants of chronic disease.
C15899	Clinical_Preventive_Practices	Lifestyle_and_Disease_Prevention	Clinical Preventive Practices	NIH: Subcategory of Lifestyle and Disease Prevention in CAM. This sub-category deals with unconventional approaches whose purpose is to screen for and prevent health-related imbalances, dysfunction's and disease.  Examples include, unconventional screening and diagnostic practices, such as electro-dermal diagnostics, medical intuition, chiriography, functional cellular enzyme measures, and preventive practices such as panchakarma.
C15900	Lifestyle_Therapy	Treatment	Lifestyle Therapy	NIH: Subcategory of Lifestyle and Disease Prevention in CAM.  This sub-category deals with complete systems of lifestyle management that include: behavioral, dietary, exercise, stress management, addiction control These approaches must be used as major adjuncts to "standard care" or be applied as alternative treatments to conventional medicine practices.  To be classified in this section the project must include at least four of the five above "core" components of lifestyle management.  Examples are the Ornish or Pritikin programs.  These therapies are usually in combination with behavioral medicine systems.
C15901	Biologically_Based_Therapy	Treatment	Biologically Based Therapy|Biological Based Therapies (with ODS)	NIH: Major category of Complementary and Alternative Medicine. This category deals with natural and biologically- based interventions and practices.
C15902	Molecular_Bank	Repository_of_Specimens_and_Reagents	Molecular Bank
C15903	No_Prior_Therapy	Prior_Therapy	No Prior Therapy	No prior cancer treatment.
C15904	Prior_Extensive_Radiation	Prior_Radiation_Therapy	Prior Extensive Radiation	Having received extensive radiation before the present time.
C15905	Prior_Limited_Radiation	Prior_Radiation_Therapy	Prior Limited Radiation	Cancer therapy using ionizing radiation to a limited (< 50%) portion of the body.
C15906	Pharmacological_Biological_and_Instrumental_Interventions	Biologically_Based_Therapy	Pharmacological, Biological and Instrumental Interventions	NIH: (Subcategory of Biological Based Therapies in CAM.) This sub-category deals with products and procedures applied in an unconventional manner that are not covered in other categories. Examples include EDTA, ozone, hydrogen peroxide, Coley's toxins, apitherapy, prolotherapy, 714X, antineoplastons, and cartilage products, etc.  Included are: Coley's toxins, Mistletoe, Antineoplastons, Cartilage, EDTA, Ozone, H2O2, Hyperbaric oxygen, IAT, 714X, MHT-68, Gallo immunotherapy, Induced Remission Therapy, Cone Therapy, Revici system, Enzyme therapies, Cell therapy, Enderlin products, Cell Therapy, Bee pollen.  Procedures/devices include Apitherapy, Neural Therapy (Prolotherapy), Electrodiagnostics, Iridology, Special Functional Tests, Chirography, MORA Device.
C15907	Manipulative_and_Body-Based_Methods	Complementary_and_Alternative_Medicine	Manipulative and Body-Based Methods|Manipulative and Body-Based Systems	A category of Complementary and Alternative Medicine: procedures which rely upon movement and manipulation of the body, eg. Chiropractic. (from NCI)
C15908	Massage_and_Body_Techniques	Treatment	Massage and Body Techniques	Massage & Body Techniques This sub-category (of Manipulative & Body-Based Systems in CAM) deals with massage and other body work methods such as the Alexander technique, Rolfing and Bioenergetics, Manipulative Osteopathy etc., Osteopathic Manipulative Therapy (OMT), Cranial-sacral OMT, Swedish massage, Chinese TUINA massage & acupressure, Reflexology, Rolfing, Polarity, Body psychotherapy (see Behav. Med.), Trager body work, Alexander technique, Feldenkreis technique, Applied kinesiology, NCSA-chiropractic. (NCI)
C15909	Unconventional_Physical_Therapies	Treatment	Unconventional Physical Therapies	NIH: Unconventional Physical Therapies. This sub-category (of Manipulative & Body-Based Therapies in CAM) considers unconventional physical therapies or combinations of conventional and unconventional therapies such as hydrotherapy, diathermy, light and color therapies, colonics, alternate nostril breathing techniques, etc.
C15910	Biofield_Therapy	Energy_Therapy	Biofield Therapy|Biofields	A category of Complementary and Alternative Medicine.  This category involves systems that use "subtle energy" fields in and around the body for medical purposes. Examples include Therapeutic Touch, Reiki, Hunna, laying-on-of-hands, external Qi-Gong, etc. Included are: Therapeutic Touch, Healing Science, Healing touch, Natural healing, SHEN, Mariuel, Reiki, Huna, External QiGong, Biorelax.
C15911	Bioelectromagnetics	Manipulative_and_Body-Based_Methods	Bioelectromagnetics|Bioelectro-Magnetics	NIH: BIOELECTRO-MAGNETICS - This category (of Manipulative & Body-Based Systems in CAM) deals with unconventional uses of electromagnetic fields, both exogenous and endogenous such as extremely low magnetic fields, the measurement of cellular bioluminescence, the application of AC or DC fields for bone repair or anti-neoplastic activity, etc.
C15912	Regional_Chemotherapy	Chemotherapy|Local_Therapy	Regional Chemotherapy|regional chemotherapy	(kee-mo-THER-a-pee) Treatment with anticancer drugs directed to a specific area of the body.
C15913	Prophylactic_Cranial_Irradiation	Central_Nervous_System_Prophylaxis|Local_Therapy|Radiation_Therapy	Prophylactic Cranial Irradiation|prophylactic cranial irradiation	(pro-fih-LAK-tik KRAY-nee-ul ir-ray-dee-AY-shun) Radiation therapy to the head to reduce the risk that cancer will spread to the brain.
C15914	Topical_Chemotherapy	Regional_Chemotherapy	Topical Chemotherapy|topical chemotherapy	(kee-mo-THER-a-pee) Treatment with anticancer drugs in a lotion or cream applied to the skin.
C15915	Tracheoesophageal_Puncture	Digestive_System_Surgery	Tracheoesophageal Puncture|tracheoesophageal puncture	(TRAY-kee-o-eh-SOF-uh-JEE-al PUNK-chur) A small opening made by a surgeon between the esophagus and the trachea. A valve keeps food out of the trachea but lets air into the esophagus for esophageal speech.
C15916	Central_Nervous_System_Prophylaxis	Cancer_Treatment	Central Nervous System Prophylaxis|CNS Prophylaxis|CNS prophylaxis	(pro-fih-LAK-sis) Chemotherapy or radiation therapy given to the central nervous system (CNS) as a preventive treatment. It is given to kill cancer cells that may be in the brain and spinal cord, even though no cancer has been detected there.
C15917	Arterial_Embolization	Embolism	Arterial Embolization|arterial embolization	(ar-TEE-ree-al EM-bo-lih-ZAY-shun) The blocking of an artery by a clot of foreign material. This can be done as treatment to block the flow of blood to a tumor.
C15918	Chemical_Immunotherapy	Immunotherapy	Chemical Immunotherapy|Immunotherapy, Chemical	The use of chemicals to enhance the immune system in treatment of cancer
C15919	Nutrition_Plant_Components	Nutrition_Dietary_Components	Nutrition, Plant Components	Role of plant-derived nutrients in cancer causation or prevention and in general health.
C15920	Nutrition_Protein_Amino_Acids	Nutrition_Dietary_Components	Nutrition, Protein/Amino Acids|Protein/Amino Acid Nutrition	Role of proteins and amino acids in cancer causation or prevention and in general health.
C15921	Vaccine_Related_Non-Development_Total	Vaccine_Development	Vaccine Related Non-Development, Total
C15922	Smoking_and_Health_Research	Research	Smoking and Health Research|Smoking and Health	Research focusing on all activities associated with tobacco smoking; concerns factors that influence individuals to start or stop smoking, how these factors differ by age, sex, ethnic group, educational or socioeconomic level, etc.
C15923	Cancer_Genome_Anatomy_Project	Cancer_Research_Project	Cancer Genome Anatomy Project|CGAP	The Cancer Genome Anatomy Project (CGAP) is an interdisciplinary program to establish the information and technological tools needed to decipher the molecular anatomy of a cancer cell.  The Cancer Genome Anatomy Project (CGAP) will unite the newest technologies, along with those both cost-effective and capable of high-throughput, to identify all the genes responsible for the establishment and growth of cancer.  CGAP has two overall goals: 1. Enhance discovery of the acquired and inherited molecular changes in cancer. 2. Evaluate the clinical potential of these discoveries. This requires the creation and dissemination of technologies that can read and interpret the molecular features of cancer. (http://www.ncbi.nlm.nih.gov/ncicgap)
C15924	Definitive_Radiation_Therapy	Retired_Concepts	Definitive Radiation Therapy
C15925	Nutrition_Alcohol	Nutrition_Dietary_Components	Nutrition, Alcohol	Role of alcoholic beverages in cancer causation or prevention and in general health.
C15926	Nutrition_Minerals	Nutrition_Dietary_Components	Nutrition, Minerals	Role of minerals in cancer causation or prevention and in general health.
C15927	Nutrition_Vitamin_B	Nutrition_Vitamins	Nutrition, Vitamin B	Role of Vitamin B, its precursons, and its analogs in cancer causation or prevention and in general health.
C15928	Nutrition_Vitamin_C	Nutrition_Vitamins	Nutrition, Vitamin C	Role of Vitamin C, its precursons, and its analogs in cancer causation or prevention and in general health.
C15929	Nutrition_Vitamin_E	Nutrition_Vitamins	Nutrition, Vitamin E	Role of Vitamin E (alpha-tocopherol), its precursons, and its analogs in cancer causation or prevention and in general health.
C15931	Clinical_Management	Healthcare_Activity	Clinical Management
C15932	Effectiveness_of_Interventions	Clinical_Testing	Effectiveness of Interventions
C15933	Health_Research_Service	Clinical_Services	Health Research Services
C15934	Risk_Factor_Services	Clinical_Services	Risk Factor Services
C15935	Surveillance_Modeling	Modeling	Surveillance Modeling
C15936	Validity_of_Self_Report	Validation	Validity of Self Report
C15937	Community_Practice	Community_Health_Services	Community Practice	Practice within a given segment of a society or a population.
C15938	Cooperative_Family_Registry	Cancer_Registry	Cooperative Family Registry|Family-Based Registry	A comprehensive, collaborative infrastructure, linked to an informatics structure, to help speed the genetic and epidemiologic study of heritable cancers. Twelve participating institutions are located in the United States, Canada, and Australia.
C15939	Cancer_Chromosome_Aberration_Project	Cancer_Genome_Anatomy_Project	Cancer Chromosome Aberration Project|CCAP|Cancer Chromosome Aberration Project (CCAP)	NCI Initiative to integrate the cytogenetic and physical maps of the human genome, generate a repository of BAC clones arrayed across the genetic and physical map, and to develop a publicly available database displaying this clone repository and providing a platform for correlation with other databases of chromosomal aberrations, as well as clinical and histopathological information.
C15940	Genetic_Annotation_Index	Other_Resources	Genetic Annotation Index	A listing of genetic variations in genes important to cancer
C15941	Interdisciplinary_Studies_in_the_Genetic_Epidemiology_of_Cancer	Cancer_Research_Project	Interdisciplinary Studies in the Genetic Epidemiology of Cancer	Collaborative and interdisciplinary genetic epidemiology investigations designed to identify and evaluate the interactions of genetic and epidemiologic risk factors leading to cancer susceptibility in individuals, families and populations, and factors influencing the rate of increase with age in cancer susceptibility. Emphasis on multi-site, cooperative research by multi- disciplinary teams of investigators wishing to collaborate within the common theme of the genetic epidemiology of cancer.  Particular emphasis is placed on encouraging interdisciplinary, population-based research focusing on the etiologic mechanisms underlying the interaction of genetic and epidemiologic risk factors for cancer susceptibility. The effect on cancer susceptibility of age-related changes over the lifespan, and the genetic factors leading to older age at onset of cancer are also of interest.
C15942	Basic_Behavioral_Studies_in_Cancer-Related_Behaviors	Basic_Behavioral_and_Social_Science_Research	Basic Behavioral Studies in Cancer-Related Behaviors
C15943	Directory_of_Cancer_Genetics_Providers	Other_Resources	Directory of Cancer Genetics Providers
C15944	Mouse_Cancer_Genome_Anatomy_Project	Cancer_Genome_Anatomy_Project	Mouse Cancer Genome Anatomy Project|Mouse CGAP	Similar to the human CGAP. The overall goals of the m-CGAP are: a comparative assessment of mouse cancer stages with those of cognate human cancers, both to validate the mouse models and to promote crossfeeding in the identification of genes that characterize those cancers; the discovery of new genes and gene pathways involved in the stages of carcinogenesis.
C15945	Small_Animal_Imaging_Resource_Programs	Diagnostic_Imaging_Program	Small Animal Imaging Resource Programs|SAIRP|Small Animal Imaging Resource Programs (SAIRPs)	A program to improve access to researchers testing new approaches to diagnosis, treatment and prevention in animal models of cancer.  Focus will be on functional, quantitative imaging.  (Bypass Budget)
C15946	Development_and_Application_of_Imaging_in_Therapeutic_Studies	Technology_Development	Development and Application of Imaging in Therapeutic Studies	This initiative will encourage applications that apply imaging technologies in the assessment of investigational cancer therapeutic agents. The proposed research projects will focus on the development and application of non-invasive tools for the functional or quantitative assessment of biochemical, genetic, or pharmacologic activity of specific therapeutic agents, or the defined biochemical pathway(s) in which they act. (from an RFA description)
C15947	Cooperative_Trial_in_Diagnostic_Imaging	Diagnostic_Imaging_Program	Cooperative Trial in Diagnostic Imaging	A single national Network of investigators that will perform multi-institutional clinical trials in diagnostic imaging related to cancer. The Network will have the capability to conduct a broad spectrum of clinical trials in imaging. This Network will generate new trials in areas of high scientific opportunity.  The Network will consist of a Headquarters office that coordinates operations, a Biostatistics and Data Management Center (BDMC), and a number of participating institutions in which the studies are performed.  Participating institutions will be selected by the Network's scientific leadership for their ability to contribute to the particular trials in the Network's research repertoire.
C15948	Development_and_Testing_of_Digital_Mammography_Displays_and_Workstations	Technology_Development	Development and Testing of Digital Mammography Displays and Workstations	This initiative is intended to advance the state-of-the-art in digital mammography displays and workstation design to facilitate clinical acceptance and implementation of digital mammography for improved breast cancer diagnosis. This PA will solicit research and development in three critical areas in digital mammography: 1) Softcopy Display Hardware; 2) Workstation Software and Design; and 3) Image Perception.
C15949	Human_Tumor_Gene_Index	Database	Human Tumor Gene Index|CGAP/TGI|Tumor Gene Index	Catalog of genes expressed in cells at various stages of tumor development.  hGTI is part of CGAP. (Bypass Budget)
C15950	Advanced_Technology_Center	Core_Facility	Advanced Technology Center	The concept of the Center was to have a facility whereby individuals (geneticists, cell biologists, and laboratory-based clinicians) could assemble in an arena to review technologies that are mature enough to span both science and clinics. One section of the ATC is the genome's National Institutes Sequencing Center (NISC) where the NCI sequencing and genotyping group will be located, and another part is the array facility.
C15951	Human_Specimen_Resources	Other_Resources	Human Specimen Resources
C15952	Cancer_Control_Research_Program	Cancer_Research_Project	Cancer Control Research Program
C15953	Cooperative_Family_Registries_for_Breast_and_Colorectal_Cancer_Studies	Cooperative_Family_Registry	Cooperative Family Registries for Breast and Colorectal Cancer Studies|CFRBCS	Cooperative family registries specific for breast and colorectal cancer studies.
C15954	Genetic_Annotation_Initiative	Cancer_Genome_Anatomy_Project	Genetic Annotation Initiative|CGAP Genetic Annotation Initiative|CGAP-GAI|GAI|Genetic Annotation Initiative (GAI)	NCI initiate to explore, develop and then apply technology for identification and characterization of genes important in cancer.  Based on gene discovery program in CGAP, the GAI is currently exploring the application of multiple technological approaches to searching the 3'UTR of genes for sequence variation.  Once identified and confirmed, these variants will be put into public databases maintained by NCIBI's dbSNP and CGAP web resources.  See also Cancer Genome Anatomy Project.
C15955	Heart_Research	Research	Heart Research
C15956	Nucleotide_Analog_Therapeutic	Chemotherapy	Chemotherapy, Nucleotide Analogs	Use of nucleotide analogs in cancer treatment.
C15957	Breast_Cancer_Basic_Research	Basic_Cancer_Research	Breast Cancer, Basic Research|Breast Cancer-Basic	Research on the molecular, genetic, biochemical, cellular, structural, immunological, pharmacological mechanisms and factors as they relate to the causation, progression, diagnosis, and treatment of breast cancer.
C15958	in_vitro_Assay	Animal_Testing_Alternatives	in vitro Assay	Assay conducted in an artificial environment, such as in a test tube, under a defined and controlled set of solvent and solute conditions.
C15959	Cellular_Assay	in_vitro_Assay	Cellular Assay	In vitro experiments conducted with intact, living cells.
C15960	Blood_Screening	Screening	Blood Screening	Examination of the blood from a group of usually asymptomatic individuals to detect those with a high probability of having a given disease, typically by means of inexpensive diagnostic tests.
C15961	Rehabilitation_Research	Clinical_Study	Rehabilitation Research	The study in the field of restoring the ability to live and work as normally as possible after a disabling injury or illness including physical, speech, and occupational therapy. (OMS94)
C15962	TIL_Research	Applied_Research	TIL Research	Research on tumor-infiltrating lymphocytes and their use as a cancer treatment.
C15963	Cancer_Control_Research	Research	Cancer Control Research
C15964	Neurosciences_Research	Neuroscience_and_Neuropsychiatric_Research	Neurosciences Research	Investigations in the disciplines concerned with the nervous system.
C15965	Nutrition_Other	Retired_Concepts	Nutrition, Other	Used for projects involving any aspect of diet or dietary components or contaminants; or food production, packaging, storage, or preparation in relation to health effects, whether positive or negative. Dietary components include drinking water, alcoholic beverages, and vitamin and trace element supplements. Nutrition studies will usually be in the carcinogenesis, prevention, or epidemiology programs but occasionally are associated with treatment or rehabilitation. The latter two areas may be concerned with taste, anorexia, cachexia, and difficulties in chewing or swallowing.
C15966	Nutrition_Vitamins_Other	Nutrition_Vitamins	Nutrition, Vitamins, Other	Role of vitamins other than A,B,C, or E, their precursons, and their analogs in cancer causation or prevention and in general health.
C15967	ADME_Study	Pharmacokinetics	ADME Study|Absorption, Distribution, Metabolism, and Excretion Study	A group of parameters commonly investigated during preclinical drug development.
C15968	Linscott_s_Directory	Other_Resources	Linscott's Directory	Linscott's Directory of Immunological and Biological Reagents.  No other source in the world tells you where to buy more than 54,000 different products used in Biomedical Research.: View Contents Linscott's Directory of Immunological and Biological Reagents New Macintosh Edition available September 19, at http://ourworld.compuserve.com/homepages/LINSCOTTSDIRECTORY/
C15969	NIH_Emphasis_Area	Research	NIH Emphasis Area	Research emphasis areas are medical and scientific research topics that warrant expanded support based on scientific need and opportunity, public health importance, and/or legislative mandate.  These emphasis areas are developed jointly with the scientific, medical, and public health communities.
C15970	Genetics_and_Medicine	NIH_Emphasis_Area	Genetics and Medicine	An NIH Emphasis area
C15971	Cancer_Control	Cancer_Intervention	Cancer Control|Cancer Control Science	Integrated program having an objective of reducing risk, incidence, and mortality from cancer and to enhancing the quality of life for cancer survivors. Realized through an orderly sequence of measures from genetic, epidemiologic, behavioral, social, applied, and surveillance cancer research to the development and implementation of effective interventions, and monitor and analysis of cancer trends in all segments of the population.
C15972	Biological_Immunotherapy	Immunotherapy	Biological Immunotherapy|Immunotherapy-Biological	The use of biological agents to enhance the host immune system in cancer therapy.
C15973	Immunotoxin_Cancer_Immunotherapy	Cancer_Immunotherapy|Immunotoxin_Therapy	Immunotoxin Cancer Immunotherapy|Immunotherapy, Cancer, Immunotoxin|Immunotoxin Immunotherapy For Cancer	Semisynthetic conjugates of various toxic molecules, including radioactive isotopes and bacterial or plant toxins, with specific immune substances such as immunoglobulins, monoclonal antibodies, and antigens. The antitumor or antiviral immune substance carries the toxin to the tumor or infected cell where the toxin exerts its poisonous effect.
C15974	Biological_Cancer_Immunotherapy	Biological_Immunotherapy|Cancer_Immunotherapy	Biological Cancer Immunotherapy|Biological Immunotherapy for Cancer|Immunotherapy, Cancer, Biological	Biological cancer immunology is the use of biological agents to enhance the host immune system in treatment of cancer.
C15975	Chemical_Cancer_Immunotherapy	Cancer_Immunotherapy|Chemical_Immunotherapy	Chemical Cancer Immunotherapy|Immunotherapy, Cancer, Chemical|chemical immunotherapy for cancer	Chemical Cancer Immunotherapy is the use of chemical substances to alter the interaction between the host's immune defenses and cancer cells to boost, direct, or restore the body's ability to fight cancer.
C15976	Mouse_Tumor_Gene_Index	Mouse_Cancer_Genome_Anatomy_Project	Mouse Tumor Gene Index	A component of CGAP.
C15977	Repository_Operations	Clinical_or_Research_Activity	Repository Operations
C15978	Repository_Operations_Tissues	Repository_Operations	Repository Operations, Tissues|Culturing, in vitro Vertebrate Repository Operations, Tissue
C15979	Focused_Ultrasound_Therapy	Thermal_Ablation_Therapy	Focused Ultrasound Therapy|Focused Ultrasound|High Power Focused Ultrasound|Therapy (Focused US)|Therapy, Focused Ultrasound	Minimally invasive procedure for ablating tumors.  The primary mechanism of tissue damage is thermal.
C15980	Radiometry_Microwave	Radiation_Dosimetry	Radiometry (Microwave)	The measurement of radiation by photography, as in x-ray film and film badge, by Geiger-Mueller tube, and by scintillation counting.
C15981	Supportive_Cancer_Chemotherapy	Chemotherapy	Supportive Cancer Chemotherapy|Chemotherapy, Cancer, Supportive	Treatment designed to improve the health of a chemotherapy patient but that does not directly affect the tumor.
C15982	Drug_Development_Experimental	Drug_Development	Drug Development, Experimental|Drug Testing/Development, Experimental
C15983	Combined_Pharmacological_Behavioral_Treatment	Multimodal_Therapy	Combined Pharmacological and Behavioral Treatment|Combined Pharmacological/Behavioral Treatment|Combined Pharmacological/Behavioral Treatments	Pharmacological and behavioral interventions, such as the combined use of nicotine replacement and biofeedback, for the treatment of physiological addictions, such as nicotine. (NCI/TRIP)
C15984	Combined_Prevention_Cessation_Research	Prevention_Research	Combined Prevention/Cessation Research	Studies identifying, testing, and implementing interventions among groups of individuals that are designed to both prevent and stop current use of specific substances, such as tobacco or alcohol. (NCI/TRIP)
C15985	Nicotine_Dependence_Addiction_on_Treatment	Clinical_Study	Nicotine Dependence/Addiction on Treatment	Research Studies that assess the behavioral and/or pharmacological treatment of individuals for nicotine dependence/addiction.  The specific focus of treatment interventions is the individual in clinical and physician-based settings. (NCI/TRIP)
C15986	Pharmacological_Treatment	Treatment	Pharmacotherapy|Pharmacological Treatment|Pharmacological Treatments	Treatment of disease through the use of drugs.
C15987	Tobacco_Use_and_Related_Risk_Factors_Surveillance	Cancer_Surveillance_Project	Tobacco Use and Related Risk Factors, Surveillance	Research studies that assess trends in tobacco-related risk factors, behaviors and health services to determine changes over time and the influence of these trends on cancer incidence, morbidity, mortality and survival.  (NCI/TRIP)
C15988	Tobacco_Use_Basic_Biological_Research	Basic_Science	Tobacco Use Basic Biological Research	Laboratory-based research studies that assess the effects of tobacco and tobacco products on cell biology and cellular mechanisms of action, including the role of tobacco and tobacco byproducts in the initiation and promotion of cancer and the biological.  (NCI/TRIP)
C15989	Tobacco_Use_Chemoprevention	Chemoprevention	Tobacco Use, Chemoprevention	Studies that assess the administration of specific and/or dietary modifications to reverse or suppress the carcinogenic effects of tobacco and prevent the development of invasive cancer.  (NCI/TRIP)
C15990	Tobacco_Use_Community_and_State_Intervention_Research	Smoking_and_Health_Research	Tobacco Use, Community and State Intervention Research	Research studies that test group and population-based interventions and the dissemination of group and population-based interventions to prevent and reduce tobacco use. (NCI/TRIP)
C15991	Tobacco_Use_Cessation_Research	Smoking_and_Health_Research	Tobacco Use, Cessation Research	Studies to test and implement interventions among groups of individuals that are designed to stop current use of tobacco.  (NCI/TRIP)
C15992	Tobacco_Use_Combined_Prevention_Cessation_Research	Combined_Prevention_Cessation_Research	Tobacco Use, Combined Prevention/Cessation Research	Studies to test and implement interventions among groups of individuals that are designed to both prevent the initiation of tobacco use and stop current tobacco use.  (NCI/TRIP)
C15993	Tobacco_Use_Policy_Research	Policy_Research	Tobacco Use Policy Research	Research studies that assess the effect of policies, including worksite, community, state and Federal policies, on tobacco initiation and use. (NCI/TRIP)
C15994	Basic_Biobehavioral_Research	Behavioral_Research	Basic Biobehavioral Research	Assesses basic principles of behavior, including basic laboratory research as well as research directed at individuals. (DCCPS)
C15995	Behavioral_Biological_Association	Behavioral_Research	Behavioral and Biological Associations|Behavioral/ Biological Associations	Studies assessing the basic relationships between biological and behavioral factors and/or their potential relationship on prevention and/ or cessation interventions.
C15996	Behavioral_Mechanisms	Behavioral_Research	Behavioral Mechanisms|Mechanisms of Behavior and Behavior Change	Studies that develop and test specific interventions aimed at changing negative health behaviors.
C15997	Cessation_Research	Smoking_and_Health_Research	Cessation Research
C15998	Minimal_Contact_Treatment	Treatment	Minimal Contact Treatment	Minimal interventions directed at individuals that do not involve a health care provider, such as self-help and telephone counseling.
C15999	Policy_Research	Research	Policy Research	Research studies assessing the effect of policies, including worksite, community, state and Federal policies as related to a variety of health issues.
C16000	Health_Services_Delivery_Other	Health_Care_Delivery|Patient_Care	Health Services Delivery, Other
C16001	Hospice_Planning_Development	Pediatric_Clinic_and_Service	Hospice Planning/Development
C16002	Treatment_of_Infectious_Diseases	Treatment	Treatment of Infectious Diseases|Infectious Diseases / Treatment, General|infectious diseases treatment	Treat infections with antibacterial, antifungal, antiparasite or antiviral drugs
C16003	Infectious_Diseases_Research	Clinical_Study	Infectious Diseases Research|Infectious Diseases / Laboratory	The study of infectious diseases in the laboratory
C16004	Plasma_Enhancement	Transfusion	Plasma Enhancement
C16005	New_Agent	Funding_Category	New Agents	Research into new physical or chemical means to treat disease.
C16006	Vaccine_Design	Vaccine_Development	Vaccine Design	Determining the antigens (whole virus, parts or crossreacting) to be incorporated in a vaccine
C16007	Cancer_Information_Service	Information_Resources	Cancer Information Service|CIS	A nationwide cancer information and education network sponsored by the NCI.  Provides information on prevention, treatment, and ongoing clinical trials to cancer patients and their families, people at risk for cancer, and health professionals.
C16008	Cooperative_Group_Program	Cancer_Research_Project	Cooperative Group Program	NCI-sponsored program that promotes and supports clinical trials in cancer treatment, (largely combined modality approaches); cancer prevention, and early detection within setting of a Cooperative Group.
C16009	Developmental_Therapeutics_Program	Cancer_Research_Project	Developmental Therapeutics Program|DTP|Developmental Therapeutics|Developmental Therapy	As the drug discovery and development arm of the National Cancer Institute, the Developmental Therapeutics Program (DTP) plans, conducts, and facilitates development of therapeutic agents for cancer and AIDS.  They are a resource for research materials, including Web-accessible data and tools, vialed and plated compounds, tumor cells, animals, and Investigational New Drug (IND)-directed studies.  (DTP web site)
C16010	Scientist_Exchange_Program	Research_Activity	Scientist Exchange Program	Office of International Activities sponsors two international scientist exchange programs: Short-Term Scientist Exchange Program and Oncology Research Faculty Development Program
C16011	Diet_and_Nutrition	Nutritional_Study	Diet and Nutrition
C16012	Nutrition_Artificial_Sweeteners	Nutrition_Dietary_Components	Nutrition, Artificial Sweeteners	Study of artificial sweeteners as potential carcinogens and in relation to general health.
C16013	Nutrition_Antioxidants	Nutrition_Dietary_Components	Nutrition, Antioxidants	Role of antioxidants in cancer causation or prevention and in general health.
C16014	Nutrition_Caffeine	Nutrition_Dietary_Components	Nutrition, Caffeine	Role of caffeine in cancer causation or prevention and in general health.
C16015	Nutrition_Vitamin_A	Nutrition_Vitamins	Nutrition, Vitamin A	Role of Vitamin A, its precursons, and its analogs in cancer causation or prevention and in general health.
C16016	Nutrition_Vitamins	Clinical_Study	Nutrition, Vitamins
C16017	Trace_Element_Nutrition_Selenium	Nutrition_Trace_Elements	Trace Element Nutrition, Selenium|Nutrition, Selenium	Role of selenium in cancer causation or prevention and in general health.
C16018	Diet_and_Nutrition_DCP	Cancer_Research_Project	Diet and Nutrition	Role of dietary patterns, foods, and nutrients or other dietary components in cancer incidence and prevention.
C16019	Diet_and_Nutrition_DCCPS	Cancer_Research_Project	Diet and Nutrition (DCCPS)
C16020	Breast_Cancer_Prevention_Education_and_Diagnosis_Program_Initiative	Breast_Cancer_Prevention	Breast Cancer Prevention, Education, and Diagnosis Program Initiative
C16021	Nutrition_Monitoring	Nutritional_Study	Nutrition Monitoring	Any method for determining as accurately as possible total food amount and composition ingested by subjects in dietary studies or amount of specific dietary components.
C16022	Antibody-Directed_Enzyme_Prodrug_Therapy	Biological_Immunotherapy	Antibody-Directed Enzyme Prodrug Therapy|ADEPT	A.D.E.P.T.  A systemic therapy which ensures that a specific prodrug is not converted into the active moiety anywhere but at the sites where the enzyme-linked, tumor-specific antibodies have localized.
C16023	Transgenic_Mouse_Facility	Laboratory_Animal_Production_and_Facilities	Transgenic Mouse Facility	A shared facility for creation and propagation of transgenic mice.
C16024	Animal_Barrier_Facility	Laboratory_Animal_Production_and_Facilities	Animal Barrier Facility	A shared facility which maintains a breeding stock of animals in a disease-free state.
C16025	DNA_Sequencing_Facility	Nucleic_Acid_Core_Facility	DNA Sequencing Facility|Sequencing Core	A shared facility which provides services for DNA sequencing
C16026	Blood_Brain_Barrier_Disruption_Chemotherapy	Chemotherapy	Blood Brain Barrier Disruption Chemotherapy|BBBD Chemotherapy	Treatment modality used to increase the delivery of chemotherapeutic agents and monoclonal antibodies to the central nervous system tissue through temporal disruption of blood brain barrier, the specialized system of microvascular endothelial cells that via both physical (tight junctions) and metabolic (enzymes) mechanisms limits transport of various chemical compounds, radioactive ions, and disease-causing organisms to brain parenchyma thereby maintaining the proper conditions for normal brain function.
C16027	Nucleic_Acid_Core_Facility	Core_Facility	Nucleic Acid Core Facility	A shared facility which usually provides services for DNA and RNA isolation and DNA cloning and sequencing.
C16028	Oligonucleotide_Synthesis_Facility	Nucleic_Acid_Core_Facility	Oligonucleotide Synthesis Facility	A shared facility which provides services for oligonucleotide synthesis.
C16029	Modest-Temperature_Hyperthermia	Hyperthermia_Treatment	Modest-Temperature Hyperthermia|MTH|Mild-Temperature Hyperthermia	Heating of tumors to the 40.5-42.5C range. Increases the oxygenation of tumors thereby enhancing the effect of radiation therapy.
C16030	Carbogen_Breathing	Biological_Therapy	Carbogen Breathing	Increases the oxygenation of tumors thereby enhancing the effect of radiation therapy.
C16031	Perioperative_Adjuvant_Therapy	Adjuvant_Therapy	Perioperative Adjuvant Therapy	Treatment given at the time of an operation to augment the effects of the operation.
C16032	Longterm_Follow-up	Healthcare	Longterm Follow-up
C16033	Follow-up	Healthcare	Follow-up|Active Follow-up|FU|Follow-Up|follow-up	Monitoring a person's health over time after treatment.  This includes keeping track of the health of people who participate in a clinical study or clinical trial for a period of time, both during the study and after the study ends.
C16034	Progenitor_Cell_Engraftment	Engraftment	Progenitor Cell Engraftment	Establishment of a self replicating population of stem cells with subsequent repopulation of differentiated cell types.
C16035	Three-Dimensional_Conformal_Radiation_Therapy	Radiation_Surgery	3-Dimensional Conformal Radiation Therapy|3D-CRT|Conformal Therapy|Radiation Conformal Therapy	A process by which a dose of radiation is automatically shaped to closely conform to the entire volume of the tumor, so that surrounding normal tissue is spared and treatment toxicity is decreased. (from Varian Oncology web site)
C16036	Histopathology_Facility	Core_Facility	Histopathology Facility	A core facility for preparation and analysis of histopathology samples.
C16037	Organic_Synthesis_Facility	Core_Facility	Organic Synthesis Facility	A core facility for the preparation and synthesis of organic molecules.
C16038	Investigation_of_Mechanisms_of_Drug_Resistance	Basic_Science	Investigation of Mechanisms of Drug Resistance	Basic research to understand the mechanisms that cells use to avoid being killed by cytotoxic drugs.
C16039	Autologous_Stem_Cell_Transplantation	Stem_Cell_Transplantation	Autologous Stem Cell Transplantation	The transference of stem cells within the same individual.
C16040	Immunooncology	Diagnostics_Research	Immunooncology	The study of cell surface markers on tumor cells which can be recognized by antibodies, and the development of diagnostic reagents or therapeutic strategies which rely upon immune recognition.
C16041	Ancillary_Study	Clinical_Study	Ancillary Study	Studies which are secondary to another study.
C16042	Limb_Salvage_Procedure	Surgical_Procedure	Limb Salvage Procedure|Limb Salvage Procedures	Methods to avoid amputation of an arm or leg
C16043	Electron_Microscopy_Facility	Core_Facility	Electron Microscopy Facility	A shared facility which provides services for electron microscopy.
C16044	Biostatistics_Core	Core_Facility	Biostatistics Core	A shared facility providing biostatistical services.
C16045	Food_Patterns	Nutritional_Study	Food Patterns	Investigations into the link between food choices and disease.  Similar to dietary history.
C16046	Diagnostic_Imaging_Program	Cancer_Research_Project	Diagnostic Imaging Program|Biomedical Imaging Program|DIP	(1) Plans and coordinates the development; (2) coordinates the clinical testing of new approaches in academia, industry, or in other parts of the federal government; (3) coordinates the development targeted to specific biochemical or physiological processes in cancer cells for better biologic insight into the physiology of human tumors; (4) encourages industrial commitment to the development and ultimate clinical testing relevant to cancer; (5) coordinates activities with other programs of the Institute, other federal agencies, and outside organizations; (6) coordinates the activities of the branches within the Program for productive interactions and effective technology transfer; and (7) assesses the activities of the Program and advises the Division Director regarding scientific opportunities for the development of new approaches to the diagnosis and treatment of cancer. (From http://www.nci.nih.gov/oma/HNCB8.htm)
C16047	Community_Oncology_and_Rehabilitation	Community_Health_Services	Community Oncology and Rehabilitation	Introduction, application, and evaluation of effective and practical cancer prevention, control, and rehabilitation intervention programs in community settings.
C16048	Information_Resources	Information_and_Media	Information Resources	Sources of information such as libraries, databases, and websites.
C16049	Radiotherapy_Research	Applied_Research	Radiotherapy Research|Radiation	[Therapeutic implications] Research in radiotherapy using ionizing and non-ionizing radiation and those areas in radiobiology and radiation physics that relate to radiation therapy, including laboratory investigations at the molecular, cellular, tissue, and whole animal levels. (DEA-CAACT)
C16050	Surveillance_Program	Applied_Research	Surveillance Program
C16051	Toxicity_Attenuation	Supportive_Care	Toxicity Attenuation
C16052	Breast_Cancer_Rehabilitation	Rehabilitation	Breast Cancer Rehabilitation	Any intervention to help breast cancer patients overcome the physical or psychological effects of their disease or its treatment.
C16053	Cancer_Surveillance_Research	Cancer_Research_Project|Epidemiology_Research	Cancer Surveillance Research
C16054	Drug_Synthesis_and_Chemistry	Drug_Development	Drug Synthesis and Chemistry|Drug Synthesis
C16055	CEPH_Genethon_Map	Physical_Map_of_the_Human_Genome	CEPH/Genethon Map	Physical map of the human genome
C16056	Physical_Map_of_the_Human_Genome	Information_Resources	Physical Map of the Human Genome|Physical Maps
C16057	Clone-Based_Physical_Map	Physical_Map_of_the_Human_Genome	Clone-Based Physical Map
C16058	Recombinant_Interval_Database	Database	Recombinant Interval Database
C16059	Sequence-Ready_Maps	Physical_Map_of_the_Human_Genome	Sequence-Ready Maps
C16060	Single_Nucleotide_Polymorphism_Map	Physical_Map_of_the_Human_Genome	Single Nucleotide Polymorphism Map|SNP Map	A diagram of a gene or genome showing the location of known single nucleotide polymorphisms.
C16061	Whitehead_Map_of_the_Human_Genome	Physical_Map_of_the_Human_Genome	Whitehead Map of the Human Genome
C16062	Electronic_Tracking_Database	Database	Electronic Tracking Database
C16063	Modeling	Research	Modeling
C16064	Cancer_Burden	Population_Study	Cancer Burden|National Cancer Burden	A measure of the incidence of cancer within the population and an estimate of the financial, emotional, or social impact it creates. The burden of disease is not borne equally by all population groups in the United State.
C16065	Cancer_Surveillance_Research_Program	Cancer_Research_Project	Cancer Surveillance Research Program|CSRP|Surveillance Research Program	The Surveillance Research Program (SRP) directs a program of cancer surveillance involving the collection and analysis of pertinent data in order to answer key questions about cancer incidence, morbidity, mortality, and cancer-related health status in diverse regions and in general and specific populations of the U.S. defined by sociodemographic measures.
C16066	Mortality_Map	Cancer_Surveillance_Project	Mortality Map	A visual representation of the national cancer burden.  These maps display cancer mortality data by county and state economic regions across the country.  They are color coded to distinguish between regions with high, intermediate, and low rates of cancer mortality.
C16067	Black_White_Cancer_Survival_Study	Cancer_Surveillance_Project	Black/White Cancer Survival Study|BWCSS|Black/White Cancer Study	A study designed to investigate the significance of social, behavioral, lifestyle, biological, treatment, and health care factors to the observed differences in cancer survival among African-Americans and white Americans. Data have been collected on more than 3,400 patients with cancers of the breast, colon, uterus, and bladder. This group will be followed until 1996 to characterize survival differences. (from NCI CancerNet)
C16068	Cancer_Surveillance_Project	Cancer_Research_Project	Cancer Surveillance Project	Surveillance projects which focus on issues of cancer
C16069	Breast_Cancer_Prevention_Trial	Cancer_Prevention_Trial	Breast Cancer Prevention Trial|BCPT	Part of the National Surgical Adjuvant Breast and Bowel Project, the Breast Cancer Prevention Trial (BCPT) was a clinical trial designed to see whether taking the drug tamoxifen would prevent breast cancer in women who are at an increased risk of developing the disease. The BCPT also looked at whether taking tamoxifen would decrease the number of heart attacks and reduce the number of bone fractures in these women. The study began recruiting participants in April 1992 and closed enrollment in September 1997.
C16070	Prostate_Cancer_Prevention_Trial	Cancer_Prevention_Trial	Prostate Cancer Prevention Trial|PCPT	A phase III, randomized, placebo-controlled cancer prevention trial of >18,000 men coordinated by the Southwest Oncology Group.  The trial will determine the effect of a daily dose of finasteride taken for seven years on the biopsy-proven prevalence of prostate cancer.  It is scheduled to be completed in 2004.
C16071	Pharmacobehavioral_Research	Behavioral_Research	Pharmacobehavioral Research	Evaluates new pharmacologic agents and methods of behavior modification.
C16072	ASCUS_LSIL_Triage_Study	Retired_Concepts	ASCUS/LSIL Triage Study|ALTS	A study designed to determine the best way to manage cases in which Pap smears return the mild cervical abnormalities of atypical squamous cells of undetermined significance (ASCUS) or low-grade squamous intraepithelial lesions (LSIL)
C16073	Marker_Network_for_Bladder_Cancer	Cancer_Research_Project	Marker Network for Bladder Cancer	The goal of the network is to evaluate biochemical, immunologic, genetic, and other quantifiable markers for diagnosis and prognosis of urinary bladder cancer.
C16074	Minority-Based_Community_Clinical_Oncology_Program	Community_Clinical_Oncology_Program	Minority-Based Community Clinical Oncology Program	A system designed to ensure adequate representation of minority groups in clinical trials.
C16075	Patient-Focused_Outcomes	Patient_Oriented_Research	Patient-Focused Outcomes|Patient-Centered Outcomes	Traditional methods for evaluating treatment outcome focus on disease state.  Patient-Focused Outcomes places a greater emphasis on quality of life issues.
C16076	Childhood_Cancer_Survivor_Study	Patient_Oriented_Research	Childhood Cancer Survivor Study|CCSS	An NCI-funded multi-institution project designed to better understand late effects of cancer upon cancer survivors
C16077	Clinical_Trials_Database	Database	Clinical Trials Database	Mandated by the FDA Modernization Act of 1997.  An NIH-wide database of information about federally and privately funded clinical trials regarding serious or life-threatening diseases or conditions.
C16078	Pediatric_Surgical_Procedures	Surgical_Procedure	Pediatric Surgical Procedures|Pediatric Surgery
C16079	Conventional_Surgery	Surgical_Procedure	Conventional Surgery	Surgery using a scalpel.  As opposed to laser surgery, cryosurgery, etc
C16080	Surgical_Management	Supportive_Care	Surgical Management	Postoperative care of surgery patients.
C16081	Laboratory_Sensitivity	Clinical_Testing	Laboratory Sensitivity
C16082	Marker_Discovery	Diagnostics_Research	Marker Discovery	Strategies and technologies for molecular phenotyping and biological marker discovery to improve understanding of disease and aid the pharmaceutical industry's ability to develop new therapeutic products efficiently and cost effectively. (from http://www.surromed.com/CorporateOverview.html)
C16083	Prevention_Protocols	Protocol	Prevention Protocol	The protocol associated with a clinical trial that is focused on cancer prevention.
C16084	Observational_Study	Research	Observational Study
C16085	Basic_Cancer_Research	Basic_Science	Basic Cancer Research
C16086	Cancer_Intervention	Intervention	Cancer Intervention
C16087	Animal_Testing	Testing	Animal Testing	The use of animals for testing the safety and efficacy of drugs or treatments.  It may be done as a precursor to human testing or as an alternative to human testing.
C16088	Extraordinary_Opportunities_for_Investment	Cancer_Research_Project	Extraordinary Opportunities for Investment|Extraordinary Opportunities in Cancer Research	Research areas of exceptional promise in the cancer field.  To qualify as extraordinary opportunities these research initiatives must: Respond to important recent developments in knowledge and technology; Offer approaches to cancer research beyond the size, scope, and funding of our current research activities; Be implemented with specific, defined investments; Be described in terms of achievable milestones, with clear consequences for not investing; and Promise advances for making progress against all cancers. (from 2001 Bypass Budget)
C16089	Extraordinary_Opportunity_Cancer_Genetics	Extraordinary_Opportunities_for_Investment	Extraordinary Opportunity: Cancer Genetics
C16090	Molecular_Classification_of_Tumors-Director_s_Challenge	Extraordinary_Opportunities_for_Investment	Molecular Classification of Tumors|Director's Challenge|Director's Challenge: Towards a Molecular Classification of Tumors|Extraordinary Opportunities: the Director's Challenge: Toward a Molecular Classification of Tumors|Extraordinary Opportunity: Defining the Signatures of Cancer Cells: Detection and Diagnosis|Molecular Fingerprinting Initiative|Molecular Profiling Initiative	Challenge to research community to revolutionize the classification of human tumors, away from classification based on morphology, toward a more clinically predictive and useful classification system based on molecular characterization of tumors.  (Bypass Budget)
C16091	Extraordinary_Opportunity_Imaging_Technologies	Extraordinary_Opportunities_for_Investment	Extraordinary Opportunity: Imaging Technologies	Goal: to develop a comprehensive imaging research program to fit the development of imaging technology with medical needs to create a system to evaluate new imaging technologies rapidly and effectively. (NCI Web)
C16092	Extraordinary_Opportunity_Preclinical_Models_of_Cancer	Extraordinary_Opportunities_for_Investment	Extraordinary Opportunity: Preclinical Models of Cancer	Goal: refine current models, create models that more closely parallel human cancers, devise efficient procedures that will make models available to all researchers who need them. (NCI Web)
C16093	Exogenous_Hormone_Therapy	Hormone_Therapy	Exogenous Hormone Therapy|Exogenous Hormone Use
C16094	Cardiac_Function_Study	Heart_Research	Cardiac Function Study
C16095	Clinical_Trials_Cancer_Control	Clinical_Trial	Clinical Trials: Cancer Control
C16096	Clinical_Trials_Cancer_Treatment	Clinical_Trial	Clinical Trials: Cancer Treatment
C16097	Community_Clinical_Oncology_Program	Cancer_Research_Project	Community Clinical Oncology Program|CCOP|Community Oncology|Oncology Programs	The Community Clinical Oncology Program (CCOP) was established by the National Cancer Institute (NCI) in 1983. Through this program, community physicians work with scientists conducting NCI-supported clinical trials.
C16098	Helium-Ion_Radiation	Radiation_Ionizing_Radiotherapy	Helium-Ion Radiation
C16099	Cooperative_Breast_Cancer_Tissue_Resource	Tissue_Collection	Cooperative Breast Cancer Tissue Resource|CBCTR	Provides researchers with access to approximately 8,000 cases of formalin-fixed, paraffin-embedded primary breast cancer specimens, with associated clinical data.  The collection is particularly well-suited for validation studies of diagnostic and prognostic markers.
C16100	Correlative_Study	Translational_Research	Correlative Study|CORR|Correlative	Studies designed to translate basic science findings into clinically useful tools.  Includes marker research.
C16101	HIV_Drug_Resistance_Program	Research	HIV Drug Resistance Program|HDRP|HIV DRP	This HIV initiative will create a center for retrovirology research, with emphasis on basic and translational research related to viral evolution and resistance biology. Scientific issues to be addressed in solving the problem of HIV drug resistance will require the coordinated efforts of experts in structural biology and biochemistry, molecular and clinical or in vivo virology, epidemiology, and chemistry. The new program also will include animal model studies of population dynamics and population genetics of HIV, mathematical modeling of virus populations and evolution, and, ultimately, translation of the findings into drug development.
C16102	Investigator-Initiated_Research	Research	Investigator-Initiated Research	Research conceived and conducted by scientists in laboratories and clinics across the country and at NCI.(2002 budget)
C16103	Intramural_Research	Research	Intramural Research	Research that takes place on the NCI campus.
C16104	Multi-Institutional_Clinical_Trial	Clinical_Trial	Multi-Institutional Clinical Trial
C16105	Nurses_Health_Study	Epidemiology_Research	Nurses' Health Study	The Nurses' Health Study was begun in 1976 with the establishment of a cohort of 120,700 women aged 30-55 and was principally designed to assess risk factors for breast cancer. Cohort members initially resided in 11 geographically dispersed states representing the Northeast (Massachusetts, Connecticut, New York, New Jersey, Pennsylvania, Maryland), Northcentral (Ohio, Michigan), the West (California) and the South (Texas, Florida); although the majority of participants still reside in the original 11 states, members of the cohort currently live in all 50 states. These women report on exposures and disease outcomes every two years and follow-up in the cohort has been maintained at a level of better than 90% through 1990.
C16106	Nutrition_Fats_Monosaturated	Nutrition_Fats	Nutrition, Fats, Monosaturated	Study of monosaturated fats in relation to cancer.
C16107	Non-Invasive_Cancer_Detection	Cancer_Detection	Non-Invasive Cancer Detection|Non-Invasive Detection	Methods of detection which do not require penetration of the body or body openings.
C16108	Population-Based_Registry	Cancer_Registry	Population-Based Registry
C16109	Preclinical_Testing	Testing	Preclinical Testing
C16110	Study_of_Tamoxifen_and_Raloxifene	Cancer_Prevention_Trial	Study of Tamoxifen and Raloxifene|STAR	Part of the National Surgical Adjuvant Breast and Bowel Project.  A study to compare the efficacy of Tamoxifen to Raloxifene in prevention of primary breast cancer among women at high risk for the disease.
C16111	Nutrition_Fats_Polyunsaturated	Nutrition_Fats	Nutrition, Fats, Polyunsaturated	Study of polyunsaturated fats in relation to cancer.
C16112	Clinical_Trial_Eligibility_Criteria	Clinical_Trial_Design	Clinical Trial Eligibility Criteria|Eligibility Criteria for Clinical Trials|Inclusion Criteria|Trial Eligibility Criteria	Elements of a personal medical history which are necessary to allow an individual to participate in a specific clinical trial.
C16113	Psychological_Impact_of_Cancer	Psychological_Impact	Psychological Impact of Cancer
C16114	Smoking_Prevention	Prevention	Smoking Prevention
C16115	Suicide_Gene_Therapy	Gene_Therapy	Suicide Gene Therapy
C16116	C51_Cytotoxicity_Assay	Cellular_Assay	C51 Cytotoxicity Assay
C16117	Craniospinal_Axis_Irradiation_in_Children	Extensive_Radiation|Prior_Extensive_Radiation	Craniospinal Axis Irradiation in Children
C16118	Anti-HIV_Therapy	Antiviral_Therapy	Anti-HIV Therapy|AIDS anti-HIV therapy|therapy, AIDS anti-HIV|therapy, anti-HIV	Treatment of viral infections with antiviral medication
C16119	Antiviral_Therapy	Treatment_of_Infectious_Diseases	Antiviral Therapy|Infectious Diseases / Treatment, Viral|Treatment of Infectious Diseases, Viral|treatment of viral infectious disease	All research into methods for treating viral infections.
C16120	Abdominal_Surgical_Procedures	Surgical_Procedure	Abdominal Surgical Procedures
C16121	Neoplastic_Disease_and_Pregnancy	Maternal_and_Child_Health	Neoplastic Disease and Pregnancy
C16122	Biomaterials_Research	Research	Biomaterials Research	Research on the application of biomaterials and on the development of novel materials.
C16123	Clinical_Trials_Other	Clinical_Trial	Clinical Trial, Other|Clinical Trials, Other|Other Clinical Trial	A clinical trial that is not therapeutic, preventive or diagnostic.
C16124	Prior_Therapy	Clinical_Trial_Eligibility_Criteria	Prior Therapy
C16125	High_Dose_Interferon_Alpha_2a	High_Dose_Chemotherapy|Interferon_Therapy	High Dose Interferon Alpha 2a	A treatment approved by FDA for treatment following surgery for melanoma patients who are at high risk of disease recurrence. (Bypass Budget)
C16126	Population_Database	Database	Population Database	Example: SEER and other cancer registries
C16127	Long_Island_Breast_Cancer_Study	Epidemiology_Research	Long Island Breast Cancer Study|LIBCSP|Long Island Breast Cancer Study Project	A study designed to conduct epidemiologic research on the role of environmental factors in the etiology of breast cancer in women who live in Nassau and Suffolk counties, New York. The US Congress has mandated the use of a case-control study and the Geographic Information System (GIS) database to study a list of environmental factors, including water quality, air pollution, electromagnetic fields, pesticides and other toxic chemicals, and hazardous and municipal waste. (from NIEHS Long Island Breast Cancer Study Project)
C16128	Molecular_Target	Drug_Discovery	Molecular Target	Every point of difference between premalignant or malignant cells and their normal counterparts is a potential target of opportunity for drug discovery - a molecular target of prevention or treatment. (Bypass Budget, 2002)
C16129	Small_Molecule_Chemical_Library	Diversity_Library	Small Molecule Chemical Library	Collection of small compounds (predominantly druglike organic substances synthesized using methods of combinatorial chemistry) used for screening for antineoplastic properties.
C16130	Diversity_Library	Repository_of_Specimens_and_Reagents	Diversity Library	Collections of different molecules, often produced through combinatorial synthetic methods, used as a starting pool to screen against a desired pharmacological target.
C16131	CDC_Behavioral_Risk_Factor_Surveillance_Survey	Cancer_Surveillance_Project	CDC Behavioral Risk Factor Surveillance Survey
C16132	Extraordinary_Opportunity_Genes_and_the_Environment	Extraordinary_Opportunities_for_Investment	Extraordinary Opportunity: Genes and the Environment	From NCI Priorities Web page: Opportunities now exist to determine how variations in our genes combine with environmental factors to cause cancer.
C16133	Extraordinary_Opportunity_Cancer_Communications	Extraordinary_Opportunities_for_Investment	Extraordinary Opportunity: Cancer Communications
C16134	Biobehavioral_Determinants_of_Tobacco_Use_and_Addiction	Smoking_and_Health_Research	Biobehavioral Determinants of Tobacco Use and Addiction	Studies of the links between biology and behavior aimed at identifying preexisting vulnerabilities to tobacco use.  By determining how these vulnerabilities interact with sociocultural and psychological influences on tobacco use, and by improving our ability to assess risks quantitatively, we can develop more effective prevention and cessation interventions and tailor these interventions to the people most likely to benefit from them. (Bypass Budget)
C16135	Intensity-Modulated_Radiotherapy	Three-Dimensional_Conformal_Radiation_Therapy	Intensity-Modulated Radiotherapy|IMRT|Intensity Modulated RT|Intensity Modulated Radiation Therapy	An advanced form of 3-Dimensional Conformal Radiation Therapy
C16136	Natural_History_and_Cofactors	Natural_History	Natural History and Cofactors	2B2; Risk Assessment and Prevention; Population-Based research: Natural History, Transmission, Risk Factors; Transmission; Natural History and Cofactors
C16137	Special_Populations_Research	Population_Study	Special Populations Research	Multidisciplinary research aimed at addressing and modifying the excessive cancer incidence and/or mortality rates, the lower cancer survival rates, or the inadequate cancer prevention and control services for special populations.  The term "special populations" refers to those population segments that may experience, or are known to experience, high cancer rates and/or are underserved in terms of cancer prevention and control programs.  Special populations include Alaskan natives, American Indians, Hispanics, Asian- Americans, Blacks, blue-collar groups, the elderly, lower-income groups, native Hawaiians, and American Samoans. (DEA-CAACT)
C16138	Extraordinary_Opportunity_Molecular_Targets_of_Prevention_and_Treatment	Extraordinary_Opportunities_for_Investment	Extraordinary Opportunity: Molecular Targets of Prevention and Treatment	From NCI Priority Web page: Identifying molecular differences between normal cells and cancer cells will enable us to develop a whole new generation of treatments and preventives that affect only cancer cells.
C16139	Extraordinary_Opportunity_Research_on_Tobacco_and_Tobacco_Related_Cancers	Extraordinary_Opportunities_for_Investment	Extraordinary Opportunity: Research on Tobacco and Tobacco Related Cancers	Goal : to expand our understanding of tobacco addiction and the biological mechanisms underlying tobacco-induced cancers, develop ways to keep people of all ages from using tobacco, create interventions to prevent tobacco-related cancers in smokers and former smokers, and develop treatments for tobacco addiction and the cancers it causes. (from NCI Initiatives Web page)
C16140	Intervention_Trial	Clinical_Trial	Intervention Trial
C16141	Pain_Research	Clinical_Study	Pain Research	Research as to the cause of pain and the treatment thereof
C16142	Acupuncture_and_Oriental_Medicine	Alternative_Medical_System	Acupuncture and Oriental Medicine	Subcategory of Alternative Medical Systems in CAM. These systems of practice include areas acupuncture, acupressure, herbal applications, massage, diet, and exercises. These practices, especially in the form of Traditional Chinese Medicine have a prominent position in the U.S. Included are: Acupuncture, Herbal formulas, Diet, QiGong, Tai chi, Massage, manipulation, Acupotomy - Fibrosis, Fibromylogic electroacupuncturers used in China at Grant Wall Hospital. (NIH)
C16143	Repository_of_Specimens_and_Reagents	Research_Resources	Repository|Bank|Repository of Specimens and Reagents	A facility where things can be deposited for storage or safekeeping.
C16144	Combination_Drug_Therapy	Treatment	Combination Drug Therapy|Drug Therapy, Combination	Drug therapy with two or more drugs given separately or together for a combined effect.
C16145	Donor_Lymphocyte_Infusion	Adoptive_Immunotherapy|Infusion	Donor Lymphocyte Infusion
C16146	Public_Health_Applications_Research	Cancer_Research_Project	Public Health Applications Research|Public Health Applications	Involvement of the public health community (i.e., state and local health departments) in the development of initiatives and programs for cancer risk reduction, and cancer prevention and control.  Primary interest is in 1) research on interventions in cancer control in public health settings and 2) the dissemination and application of research findings among public health agencies and professionals.
C16147	Natural_History	Applied_Research	Natural History	Elucidation and description of disease progress.
C16148	Exclusion_Criteria	Clinical_Trial_Design	Exclusion Criteria	Elements of a personal medical history which would prevent an individual from participating in a specific clinical trial.
C16149	Progesterone_Receptor_Status	Clinical_Trial_Eligibility_Criteria	Progesterone Receptor Status|PgR Status	Indicates the progesterone receptor level measured in a primary tumor or in metastases. (>=10 is positive if measured in fmols/mg cytosol protein; Otherwise use institutional standards)
C16150	Estrogen_Receptor_Status	Clinical_Trial_Eligibility_Criteria	Estrogen Receptor Status|ER Status	The estrogen receptor level measured in a primary tumor or in metastases.  There are essentially two distinct forms of breast cancer, one that tends to have an early onset and is characterized by an ER- status, and one that tends to have a late onset and is characterized by an ER+ status.  However, these two variants tend to overlap with respect to age, so it is possible for a young woman to have a "late-onset" form of breast cancer and for an older woman to have an "early-onset" variant of the disease.
C16151	Menopausal_Status	Clinical_Trial_Eligibility_Criteria	Menopausal Status
C16152	Her2_Neu_Status	Clinical_Trial_Eligibility_Criteria	Her2/Neu Status|Her2/Neu Value	Her2/Neu status defined at original diagnosis.  (NCI CDE Dictionary)
C16153	Stratification_Factors	Clinical_Trial_Design	Stratification Factors	Selected pre-treatment factors by which patients are segregated to assure equal balance of these factors before randomization to the intervention arms of a clinical protocol.
C16154	Treatment_Step	Clinical_Trial_Design	Treatment Step|Step	A specific stage of progression through a sequential treatment protocol.
C16155	Prior_Adjuvant_HDC_ASCT	Prior_Chemotherapy	Prior Adjuvant HDC/ASCT|HDC/ASCT|Prior Adjuvant High-Dose Chemotherapy with Stem Cell Support
C16156	Prior_Adjuvant_Hormonal_Therapy	Prior_Hormone_Therapy	Prior Adjuvant Hormonal Therapy
C16157	Prior_Adjuvant_Immunotherapy	Prior_Immunotherapy	Prior Adjuvant Immunotherapy
C16158	Prior_Adjuvant_Other_Therapy	Prior_Therapy	Prior Adjuvant Other Therapy
C16159	Number_of_Prior_Chemotherapies	Prior_Chemotherapy	Number of Prior Chemotherapies|Multiple Agents Therapy	Number of prior chemotherapy regimens: If a patient has received a chemotherapy regimen, provide the number of different single or multi agent chemotherapy regimens the patient has received.  A regimen is described as a distinctive collection of agent(s) and/or modalities to be utilized together during a cycle or course of therapy.  A chemotherapy regimen may have been discontinued for any reason (e.g. completion of therapy, toxicity, disease progression).  If the planned treatment is ABVD/MOPP code as one chemotherapy regimen.
C16160	Genetic_Population_Study	Population_Study	Genetic Population Study
C16161	Four_A_s_Treatment_Protocol	Smoking_Cessation_Intervention|Treatment_Regimen	4A's Treatment Protocol|4A's Treatment Strategy|4As Treatment Protocol|4As Treatment Strategy	A smoking cessation strategy recommended by the National Cancer Institute.  The first 'A' is to ask patients about their smoking status at every visit and record this information. The second 'A' is to advise smokers to quit. The third 'A' is to assist patients' cessation attempts where possible by helping them to set a quit date, providing self-help materials, prescribing pharmacological treatment, and recommending counseling. The final 'A' is to arrange follow-up contact. (from Medscape)
C16162	Nicotine_Nasal_Spray	Nicotine_Replacement	Nicotine Nasal Spray	A method for nicotine replacement.
C16163	Polyp_Prevention_Trial	Cancer_Prevention_Trial	Polyp Prevention Trial	Investigated low fat, high fiber diets in preventing recurrence of colorectal polyps
C16164	Low_Fat_High_Fiber_Diet	Diet	Low Fat, High Fiber Diet
C16165	Highly_Active_Antiretroviral_Therapy	Antiviral_Therapy	Highly Active Antiretroviral Therapy|HAART	Drug therapy which targets retrovirus function by multiple mechanisms.
C16166	Prostate_Cancer_Outcomes_Study	Cancer_Research_Project|Patient_Oriented_Research	Prostate Cancer Outcomes Study|PCOS	A study initiated in 1994 by researchers at the National Cancer Institute (NCI) to look at the impact that treatments for primary prostate cancer have on the quality of life of patients.  PCOS is the first systematic evaluation of health-related quality-of-life issues for prostate cancer patients conducted on a multiregional scale. (from NCI Press Release: http://rex.nci.nih.gov/massmedia/press releases/prost_outcome.html)
C16167	gp100_Human_Melanoma_Peptide_Vaccine_with_Incomplete_Freunds_Adjuvant	Melanoma_Vaccine	gp100 Human Melanoma Peptide Vaccine with Incomplete Freund's Adjuvant|gp100 human melanoma peptide vaccine/incomplete Freund's adjuvant|gp100 human melanoma-associated antigen with incomplete Freund's adjuvant|gp100 human melanoma-associated antigen/incomplete Freund's adjuvant	A vaccine consisting of synthetic glycoprotein 100 (gp100) melanoma antigen and incomplete Freund's adjuvant (IFA), an emulsifying agent and immune system stimulant, with antineoplastic activity.  Vaccination with gp100 human melanoma peptide vaccine with IFA stimulates the host immune system to direct cytotoxic T lymphocytes (CTL) against gp100 positive melanoma cells, resulting in decreased tumor growth. (NCI04)
C16168	Prior_Immunotherapy	Prior_Therapy	Prior Immunotherapy	Originally, therapeutic administration of serum or gamma globulin containing preformed antibodies produced by another individual; currently, immunotherapy includes nonspecific systemic stimulation, adjuvants, active specific immunotherapy, and adoptive immunotherapy.  New forms of immunotherapy include the use of monoclonal antibodies.  This approach has been widely adopted by cancer specialists, often in cases which fail to respond to other treatment.  Immunotherapy aims to boost immune system function, as with the administration of interferons and interleukin-2, or to attack cancerous cells directly, as with the injection of monoclonal antibodies.  Various immunotherapeutic techniques have also been employed among AIDS patients.  In addition, a number of alternative medical practices are claimed to enhance immune function, and various over-the-counter substances (e.g., goldenseal, lysine have gained popularity for this supposed property.
C16169	Prior_Surgery	Prior_Therapy	Prior Surgery
C16170	Prior_Gene_Therapy	Prior_Therapy	Prior Gene Therapy
C16171	Prior_Chemotherapy	Prior_Therapy	Prior Chemotherapy|Prior Chemotherapy Regimens	Previous chemotherapy administered as treatment for this cancer.
C16172	Other_Prior_Therapy	Prior_Therapy	Other Prior Therapy
C16173	National_Breast_and_Cervical_Cancer_Early_Detection_Program	Cancer_Research_Project	National Breast and Cervical Cancer Early Detection Program|NBCCEDP|Women's Health Check Program	A program of the CDC.  Established by an act of Congress in 1990 it provides for screening exams to underserved women.
C16174	Compartmental_Treatment	Local_Therapy	Compartmental Treatment
C16175	Prior_Hormone_Therapy	Prior_Therapy	Prior Hormone Therapy|prior hormonal therapy
C16176	Tobacco_Surveillance	Surveillance	Tobacco Surveillance	Surveillance to improve the capacity to identify and understand emerging disparities in tobacco use, particularly among at risk youth. (from The NCI Strategic Plan to Reduce Health Disparities)
C16177	NCI_Strategic_Plan_to_Reduce_Health_Disparities	Cancer_Research_Project	NCI Strategic Plan to Reduce Health Disparities	The overall goal is to understand the causes of health disparities in cancer and to develop effective interventions to eliminate these disparities. (from The NCI Strategic Plan to Reduce Health Disparities)
C16178	Center_for_Population_Health	Cancer_Research_Project	Centers for Population Health	Centers for Population Health will be created to: 1) expand understanding of the social (e.g., income disparities, racial discrimination) and other causes of cancer-related health disparities, 2) develop new hypotheses for cancer control at social, institutional, and policy levels, and 3) develop, apply, evaluate, and disseminate interventions to improve population health. (from The NCI Strategic Plan to Reduce Health Disparities)
C16179	Selenium_and_Vitamin_E_Efficacy_Trial	Prostate_Cancer_Prevention_Trial	Selenium and Vitamin E Efficacy Trial|SELECT|Selenium and Vitamin E Cancer Prevention Trial	The Selenium and Vitamin E Efficacy Trial (SELECT) will provide more definitive evidence of the efficacy of these drugs in preventing prostate cancer. (from The NCI Strategic Plan to Reduce Health Disparities)
C16180	Total_Mesorectal_Excision	Colon_and_Rectal_Surgery|Excision	Total Mesorectal Excision|TME	Surgery for rectal cancer involving precise removal of an intact mesorectal envelope with tumor-free margins.  Associated with local recurrence rates below 5% in clinical trials.  (from Medscape)
C16181	Cancer_Biomarkers_Research_Group	Cancer_Research_Project	Cancer Biomarkers Research Group	The mission of the CBRG is to engage basic and clinical scientists as well as epidemiologists and statisticians in a search for and validation of promising early cancer biomarkers. To do so, the CBRG supports and facilitates a broad spectrum of national and international research activities in molecular biology and genetics, particularly for the discovery of biomarkers for risk prediction and early detection of cancer. The CBRG also supports the development of databases and informatics systems to optimize tracking and assessment of biomarker utility and expression patterns. (from http://dcp.nci.nih.gov/cbrg/index.html)
C16182	Cooperative_Family_Registry_for_Epidemiologic_Studies_of_Colon_Cancer	Cooperative_Family_Registry	Cooperative Family Registry for Epidemiologic Studies of Colon Cancer	Cooperative family registries specific for colon cancer studies.
C16183	Telehealth	Telemedicine	Telehealth	Describes health care provided to remote patients using a combination of satellite dishes, computers, and video-conferencing equipment. (Wordspy.com)
C16184	Gel_Dosimetry	Radiation_Dosimetry	Gel Dosimetry	Gel dosimetry involves filling a model of a body part, such as the head, neck or breast, with a gel mixture. The gel-filled model (phantom) then undergoes MRI, CT, ultrasound, or radiation therapy, to gauge how effective the same procedure might be for the patient. Radiation alters the chemical structure of the gel, and the changes appear when scientists view a cross-section of the phantom on the computer screen.  (from Medscape)
C16185	Imaging_Guided_Therapy	Treatment	Imaging Guided Therapy|Image Guided Therapy	The use of imaging techniques to provide the basis for therapy. eg. commonly used for surgery, such tools enable surgeons to visualize internal structures through an automated overlay of 3D reconstructions of internal anatomy on top of live video views of a patient.  Also used for guidance of biopsy needles. (NCI/OSP)
C16186	Orthopedic_Surgical_Procedure	Surgical_Procedure	Orthopedic Surgical Procedure|Orthopedic Surgical Procedures	A surgical procedure to treat and correct deformities, diseases, and injuries to the skeletal system, its articulations, and associated structures.
C16187	Whole-Brain_Radiotherapy	Extensive_Radiation|Prior_Extensive_Radiation	Whole-Brain Radiotherapy	Radiation treatment modality used as major component in treatment of primary and metastatic brain tumors. This is a standard treatment for multiple brain metastases.
C16188	Transurethral_Electrovaporization_of_the_Prostate	Transurethral_Prostatic_Resection	Transurethral Electrovaporization of the Prostate|TUVP	Application of electrical energy to electrosurgically vaporize or remove the obstructive enlarged prostatic tissue.  In electrosurgical vaporization, the electrode rapidly heats the tissue cells so that they turn into steam, leaving a space where the prostate tissue was previously present. (from Columbia University Department of Urology)
C16189	Atlas_of_Cancer_Mortality_in_the_United_States	Database	Atlas of Cancer Mortality in the United States|Cancer Maps	The NCI's Atlas of Cancer Mortality in the United States, 1950-94, shows the geographic patterns of cancer death rates in over 3,000 counties across the country over more than four decades. It contains the 254 color-coded maps (for about 40 cancers), that will make it easy for researchers and state health departments to identify places where high or low rates occur, and to uncover patterns of cancer that would escape notice if larger areas, such as states, were mapped. The atlas will not tell researchers why death rates are higher in certain localities than in others, but it will provide important clues for further in-depth studies into the causes and control of cancer. (from NCI press release http://rex.nci.nih.gov/massmedia/press releases/atlas.html)
C16190	Cancer_Care_Outcomes_Research_and_Surveillance_Consortium	Cancer_Surveillance_Project	Cancer Care Outcomes Research and Surveillance Consortium|CanCORS	A funding project supporting research towards measuring the quality of cancer care in the United States.  It is to be a five-year project (starting which will support prospective cohort studies on 10,000 patients with newly diagnosed lung or colorectal cancers. The project is designed to increase the knowledge of the relationship between cancer care practices in the general population and patient outcomes including survival and quality of life. (http://healthservices.cancer.gov/cancors.html)
C16191	Tissue_Array_Research_Program	Cancer_Research_Project	Tissue Array Research Program|TARP	The new Tissue Array Research Program (TARP) is a collaborative effort between the National Human Genome Research Institute and NCI to continued advances in detection, diagnosis, and development of targeted cancer therapies.  Among its aims are: 1) Advance tissue microarray technology research and development, 2) Produce tissue microarrays for use by the research community, 3) Serve as an arraying facility for groups with unique tissue materials, such as clinical trial groups or consortiums of rare diseases, 4) Disseminate tissue microarray technology by providing training, workshops, establishing protocols and standards.
C16192	Sputum_Cytology	Cytology_Specimen_Collection_Procedure	Sputum Cytology|Sputum Cytology Screening	An investigational technique for lung cancer detection.  Looks for abnormal cell cytology in sputum.
C16193	Genoplasty	Gene_Therapy	Genoplasty	An alternative to traditional gene therapy, genoplasty is a repair technology that uses short DNA fragments to induce a cell to repair its genome.
C16194	Preoperative_Endocrine_Therapy	Hormone_Therapy	Preoperative Endocrine Therapy	Short term endocrine therapy, prior to surgery, to "down-stage" primary breast cancer in order to increase the rate of breast-conserving surgery.  (from JMCC 7:557-562, 2000 via Medscape)
C16195	AIDS_and_Cancer_Specimen_Bank	Tissue_Collection	AIDS and Cancer Specimen Bank|ACSB	The ACSB provides qualified researchers with tissue, cell, blood and fluid specimens, as well as clinical data from patients with HIV-related malignancies.  The ACSB contains formalin-fixed paraffin embedded tissues, fresh frozen tissues, malignant cell suspensions, fine needle aspirates, and cell lines from patients with HIV-related malignancies. The bank also contains serum, plasma, urine, bone marrow, cervical and anal specimens, saliva, semen and multi-site autopsy tissues from patients with HIV-related malignancies including those who have participated in clinical trials. The bank has an associated database that contains prognostic, staging, outcome and treatment data on patients from whom tissues were obtained. (CancerNet)
C16196	Clinical_Trials_Cooperative_Groups_Human_Tissue_Resources	Tissue_Collection	Clinical Trials Cooperative Groups Human Tissue Resources|CTCG Human Tissue Resources	A collection of banked tumor specimens from large numbers of uniformly treated cancer patients with a variety of malignancies.
C16197	Intervention	Clinical_or_Research_Activity	Intervention|INTVN|Intervention Strategies|Interventions	Activity or measure that produces an effect or that is intended to alter the course of a disease in patient or population. This is a general term encompassing medical, social, behavioral, environmental and other acts that can have preventive and/or therapeutic impact.
C16198	Protein_Structure_Initiative	Research	Protein Structure Initiative|PSI	A NIGMS initiative to define the basic protein shapes and to catalog all proteins in terms of these shapes.  This project will require the determination of a large number (perhaps 10,000) of protein structures in a high throughput mode.  (from RFA: GM-99-009)
C16199	Cancer_Research_Project	Research	Cancer Research Project|Cancer Research Programs
C16200	Stem_Cell_Research	Research	Stem Cell Research
C16201	Hematopoietic_Stem_Cell_Research	Stem_Cell_Research	Hematopoietic Stem Cell Research
C16202	Non-Hematopoietic_Stem_Cell_Research	Stem_Cell_Research	Non-Hematopoietic Stem Cell Research
C16203	Clinical_or_Research_Activity	root_node	Clinical or Research Activity
C16204	MAGE-3-1_PADRE-965-10	Chemotherapy_Regimen	MAGE-3/PADRE 965.10|MAGE-3.1/PADRE 965.10
C16205	Healthcare_Activity	Clinical_or_Research_Activity	Healthcare Activity|Health Care Activity	The actions of prevention, treatment, and management of illness and the preservation of mental and physical well-being through the services offered by the medical and allied health professions.
C16206	Energy_Therapy	Treatment	Energy Therapy
C16207	Bioelectromagnetic-Based_Therapy	Energy_Therapy	Bioelectromagnetic-Based Therapy
C16208	EST_Library	Expression_Library	EST Library
C16209	Early_Detection	Detection	Early Detection	Use of a device, marker, or other means for the purpose of detecting the presence of a tumor early in its development.
C16210	Detection	Intervention	Detection
C16211	Tobacco_Use_Prevention_Research	Smoking_and_Health_Research	Tobacco Use Prevention Research	Studies to develop and test interventions that are designed to prevent the initiation of tobacco use among individuals. (NCI/TRIP)
C16212	Cancer_Treatment	Treatment	Cancer Treatment|Cancer Therapy|Malignant Neoplasm Therapy|Malignant Neoplasm Treatment	Any intervention for management of a malignant neoplasm.
C16213	Cancer_Diagnosis	Diagnosis	Cancer Diagnosis	General term for detecting and classifying cancer in patients. (from CSP94)
C16214	Mutagenicity_Test	Carcinogen_Screening	Mutagenicity Test
C16215	Soft_Agar_Assay	Carcinogenicity_Test	Soft Agar Assay	Soft agar colony formation assay is performed to assay for anchorage independent growth.
C16216	Matrigel_Invasion_Assay	Carcinogenicity_Test	Matrigel Invasion Assay	Matirgel is considered as basement membrane and generated from EHS sarcoma. Matrigel contains not only basement membrane components (collagens, laminin, and proteoglycans) but also matrix degrading enzymes/their inhibitors and growth factors. Invasion of tumor cells into Matrigel has been used to characterize involvement of ECM receptors and matrix degrading enzymes which play roles in tumor progression. Matrix metalloproteinases (MMPs) are a family of enzymes known to degrade components of the extracellular matrix (ECM) and their activity and secretion have been implicated in tumor invasion. (from iProtocol, http://iprotocol.mit.edu/protocol/284.htm)
C16217	Tumor_Formation_in_Athymic_Mice	Carcinogenicity_Test	Tumor Formation in Athymic Mice
C16218	Nerve-Sparing_Prostatectomy	Prostatectomy	Nerve-Sparing Prostatectomy|Nerve-Sparing Surgery	A type of surgical prostatectomy which attempts to spare the nerves that control erection.
C16219	Seed_Implantation	Radiation_Brachytherapy	Seed Implantation
C16220	ORESTES_Library	EST_Library	ORESTES Library	Expressed Sequence Tags positioned in open reading frames.
C16221	Protein_Replacement_Therapy	Replacement_Therapy	Protein Replacement Therapy|Enzyme Replacement Therapy	Administration of a protein to compensate for the loss, as from disease or surgery, of a gland or tissue that would normally produce the protein.
C16222	Psychological_Impact	Social_Aspects_of_Cancer	Psychological Impact
C16223	Library	Repository_of_Specimens_and_Reagents	Library|DNA Library	A collection of DNA molecules that have been cloned in vectors.
C16224	SAGE_Library	Expression_Library	SAGE Library	Serial analysis of gene expression (SAGE) is novel method of assessing the variation in the type or amount of genes expressed in different tissues, at different times in development or in normal versus malignant cells.
C16225	Nutrition_Vitamin_D	Nutrition_Vitamins	Nutrition, Vitamin D
C16226	Health_and_Behavior	Behavioral_Research	Health and Behavior	Research into the combination of knowledge, practices, and attitudes that motivate the actions we take regarding health.
C16227	MOP_Photochemotherapy	PUVA_Photochemotherapy	MOP Photochemotherapy
C16228	UVA_Light_Therapy	UV_Light_Therapy	UVA Light Therapy	Light therapy using ultraviolet radiation between 320 to 400 nm.
C16229	Case_Series	Study_Design	Case Series|case series	A group or series of case reports involving patients who were given similar treatment.  Reports of case series usually contain detailed information about the individual patients.  This includes demographic information (for example, age, gender, ethnic origin) and information on diagnosis, treatment, response to treatment, and follow-up after treatment.
C16230	Extensive_Radiation	Radiation_Therapy	Extensive Radiation	Cancer therapy using ionizing radiation to a significant (>50%) portion of the body, e.g. craniospinal, total body irradiation, or pelvic radiation.
C16231	Myeloablative_Chemotherapy	Bone_Marrow_Ablation	Myeloablative Chemotherapy
C16232	Expression_Library	cDNA_Library	Expression Library
C16233	Nutrition_Macronutrients	Nutrition_Dietary_Components	Nutrition, Macronutrients|Macronutrients
C16234	Clinical_Sensitivity	Clinical_Testing	Clinical Sensitivity
C16235	Ames_Assay	Mutagenicity_Test	Ames Assay	The Ames test is a method in genetics to test the strength of a mutagen, that is, if an agent (for example, a chemical), causes mutations in living organisms. The test is named after its inventor, Bruce Ames.  The test works by taking bacteria that already have a single mutation, for example, a strain that cannot produce histidine, an amino acid that is essential for the bacterium to live. These bacteria are then exposed to the agent to be tested, and brought into an environment that is ideal for them to live and procreate, except it does not contain histidine. The more mutations the agent caused in the bacteria, the more likely it is for some of them to reverse the original mutation, that is, that the mutation occurs exactly in the right place to allow the bacteria to produce histidine again by themselves. The number of surviving bacteria colonies thus corresponds with the strength of the mutagen. (from Wikipedia)
C16236	Antisense_Oligonucleotide_Therapy	Gene_Therapy	Antisense Oligonucleotide Therapy
C16237	Validation	Clinical_Testing	Validation	Validation; the act of validating; finding or testing the truth of something.
C16238	Predictive_Value	Value	Predictive Value	An expression of the likelihood that a given test result correlates with the presence or absence of disease. (from On-line Medical Dictionary)
C16239	Oncogene_ErbB2	ERBB2_Gene	Oncogene ErbB2|HER -2|HER-2/NEU|Oncogene, C-Erb -2|Oncogene, C-ErbB-2|Oncogene, ERBB2|Oncogene, NEU	Human Oncogene ErbB2 is a mutated variant of ERBB2 Gene, which encodes ERRB2 Receptor Protein Tyrosine Kinase, a 185-kDa type I membrane glycoprotein similar to EGFR that controls cell growth. Ligand binding increases ERBB2 tyrosine phosphorylation. A heterodimer with ERBB3 and ERBB4, p185ERBB2 is an essential component of the heregulin/neuregulin receptor. ERBB2 forms an IL6-dependent complex with IL6R gp130, resulting in ERBB2 tyrosine phosphorylation and MAPK activation. Oncogene ERBB2 disrupts normal cell function.
C16240	Oncogene_CSF1R	CSF1R_Gene	Oncogene CSF1R|Oncogene FMS	Human colony stimulating factor 1 receptor (CSF1R) gene, located at 5q33.2-q33.3, encodes macrophage colony stimulating factor I receptor protein. Mutations in this gene have been detected in both chronic myelomonocytic leukemia and type M4 acute myeloblastic leukemia. One out of fifty hematologically normal individuals exhibit a CSFR1 variant allele (Y969C) that may cause a predisposition to myeloid malignancy.
C16242	Exonuclease	Esterase	Exonuclease	An Exonuclease is a hydrolase (nuclease) that specifically catalyzes the hydrolysis of terminal phosphodiester bonds of deoxyribonucleotide or ribonucleotide chains, releasing mononucleotides.
C16243	Five_Prime-Three_Prime_Exonuclease	Exonuclease	5'-3' Exonuclease	Five Prime-Three Prime Exonucleases specifically catalyze the hydrolysis of terminal phosphodiester bonds of nucleic acids. Human XRN1 and XRN2 are similar to mouse Dhm1 and yeast dhp1, involved in homologous recombination, meiosis, telomere maintenance, RNA synthesis and RNA trafficking. XRN1 localizes to cytoplasmic complexes of mRNA-degrading enzymes and prefers RNA over DNA substrates. XRN2 promotes transcription termination by 5-prime to 3-prime exonuclease activity and autocatalytic cotranscriptional cleavage that may induce dissociation of RNA polymerase II from the DNA template, but function has not yet been fully determined.
C16253	CRYPTIC_Gene	Growth_Factor_Gene	CFC1 Gene|CFC1|CRYPTIC|Criptic Protein Gene|Cripto|Cryptic Protein Gene|HTX2	Cripto is a novel, transforming gene of the epidermal growth factor family.  Cripto is an essential co-factor for Nodal family proteins, which are essential signaling molecules for mesoderm development.  Transcripts are detected only in undifferentiated cells and disappear after cell differentiation induced by retinoic acid treatment.  In mice, Cripto is required for germ-layer formation and the correct positioning of the anterior-posterior axis.  Prior to gastrulation, Cripto expression is initially symmetric and uniform in the epiblast, and then becomes asymmetric in a proximal-distal gradient.
C16254	Hydroxysteroid-17-Beta_Dehydrogenase-2	Oxidoreductase	Hydroxysteroid 17-Beta Dehydrogenase 2|17-Beta Hydroxysteroid Dehydrogenase|17-Beta-HSD|EC 1.1.1.62|Estradiol 17 Beta-Dehydrogenase|HSD17B2	Expressed in many peripheral tissues (high in placenta) by human HSD17B2 Gene (SDR Family), 387-aa 43-kDa Hydroxysteroid 17-Beta Dehydrogenase 2 is a potential type II membrane protein enzyme with an N-terminal type II signal-anchor motif and a C-terminal ER retention motif, likely associated with ER membranes, that uses NADH in the oxidative inactivation metabolism of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 also has 3-beta-HSD activity and 20-alpha-HSD activity toward 20-alpha-dihydroprogesterone. (NCI)
C16255	Acetylation	Biochemical_Reaction	Acetylation	Acetylation involves the covalent linkage of an acetyl group into an organic molecule.
C16256	Acoustic	General_Modifier	Acoustic|acoustic	(ah-KOOS-tik) Having to do with sound or hearing.
C16257	Actin-Binding_Protein	Ligand_Binding_Protein	Actin-Binding Protein|ABP|Actin Binding Proteins	A diverse group of proteins that bind to actin. These proteins direct a complex network of protein filaments that provide stability to the cellular infrastructure by supporting the dynamic motility of microfilaments, thereby enabling intracellular translocation and organelle transport.
C16258	Actin	Microfilament_Protein	Actin	A globular subunit of microfilaments, highly conserved Actin is one of the most abundant proteins in eukaryotic cells. Monomeric actin, a slow ATPase composed of a 375 amino acid polypeptide chain, interacts with one molecule of ATP or ADP and contains high affinity and low affinity binding sites for divalent cations. Actin can quickly assemble into long microfilament polymers. In conjunction with myosin, actin is responsible for the contraction and relaxation of muscle.
C16259	Acyltransferase	Transferase	Acyltransferase|Acetyltransferase|EC 2.3	Class of enzymes that catalyze the transfer of acyl groups, most commonly a carboxylic acyl group forming either esters or amides.
C16260	Adenine_Phosphoribosyltransferase	Glycosyltransferase	Adenine Phosphoribosyltransferase|APRT|EC 2.4.2.7	Human adenine phosphoribosyltransferase protein (179 aa, 19 kDa) is encoded by the human adenine phosphoribosyltransferase (APRT) gene. The cytoplasmic protein is primarily involved in an AMP purine salvage reaction that recycles adenine into nucleic acids by the formation of AMP from adenine and 5-phosphoribosyl-1-pyrophosphate.
C16261	Adenosine_Deaminase	Hydrolase	Adenosine Deaminase|ADA|Adenine Deaminase|Adenosine Aminohydrolase|EC 3.5.4.4	Adenosine deaminase catalyzes the hydrolysis of adenosine to inosine. ADA deficiency causes one form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins. (LocusLink)
C16262	Purinergic-P1_Receptor	Purinergic_Receptor	Purinergic P1 Receptor	Cell surface receptors that bind to adenosine. These receptors have an enhanced affinity for adenosine and preferentially bind to this nucleoside compared to other purine moieties present within the body. Two types of receptors, termed A1 and A2, have been identified and they are both widely expressed in the body.
C16263	ATPase	Hydrolase	ATPase|Adenosine Triphosphatase|Adenosinetriphosphatase	ATPases are a group of enzymes that catalyze ATP hydrolysis coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA. Many structural (e.g. myosin) and transport (e.g. ion pump) proteins include an ATPase domain.
C16264	Adenylate_Cyclase	Lyase	Adenylate Cyclase|ADCY9|ATP Pyrophosphate-Lyase|Adenyl Cyclase 9|Adenylyl Cyclase 9|Adenylylcyclase 9|EC 4.6.1.1	Adenylyl cyclases are membrane-associated enzymes of the lyase class that are expressed in most human tissues. These enzymes catalyze the formation of cyclic AMP and pyrophosphate from ATP and are regulated by a family of G protein-coupled receptors, protein kinases, and calcium. Adenylyl cyclase is encoded by the ADCY9 gene and widely distributed. It is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. It may play a fundamental role in situations where fine interplay between intracellular Ca(2+) and cAMP determines the cellular function. It also may be a physiologically relevant docking site for calcineurin.
C16265	Teenagers	Person	Teenager|Teenagers	An individual between the ages of 13 and 19.
C16266	Adolescents	Retired_Concepts	Adolescents	Adolescents; persons of age 13-17 (from PSY94)
C16267	Afghanistan	Country	Afghanistan|004|AF|AFG	A country in Southern Asia, north and west of Pakistan, east of Iran. (CIA World Factbook 2002)
C16268	Elderly	Patient_Characteristics_Modifier	Elderly|Aged 65 and Over|Elderly (Over 65)	An age group comprised by people 65 years of age and older.
C16269	Aging	Aging-Related_Process	Aging	The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.  Any aspect of aging: molecular, physiological, epidemiological, programs targeted to older populations.
C16270	Agriculture	Technology	Agriculture
C16271	Albania	Country	Albania|008|AL|ALB	A country in Southeastern Europe, bordering the Adriatic Sea and Ionian Sea, between Greece and Serbia and Montenegro. (CIA World Factbook 2002)
C16272	Alcohol_Dehydrogenase	Oxidoreductase	Alcohol Dehydrogenase	Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products.
C16273	Alcohol_Consumption	Personal_Behavior	Alcohol Consumption	consumption of liquids containing ethanol; includes the behavior of drinking the alcohol.
C16274	Algeria	Country	Algeria|012|AG|DZ|DZA	A country in Northern Africa, bordering the Mediterranean Sea, between Morocco and Tunisia. (CIA World Factbook 2002)
C16275	Algorithms	Mathematics	Algorithm|Algorithms	A defined procedure for solving a problem.  Applied to a problem-solving procedure implemented in software to be executed by a computer.
C16276	Alkaline_Phosphatase	Phosphatase	Alkaline Phosphatase|AP	An enzyme that catalyses the cleavage of inorganic phosphate non-specifically from a wide variety of phosphate esters and having a high (greater than 8) pH optimum. (from On-line Medical Dictionary)
C16277	Allele	Miscellaneous_Molecular_Biology_Terms	Allele|Alleles	Alleles are mutually exclusive alternative forms of the same gene occupying the same locus on homologous chromosomes, differing in DNA sequence and governing the same biochemical and developmental process.
C16278	Alpha-Fetoprotein	Ligand_Binding_Protein	Alpha-Fetoprotein|AFP|Alpha-1-Fetoprotein|Alpha-Fetoglobulin|alpha-fetoprotein	Alpha-fetoprotein is a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. (from LocusLink)
C16279	Alpha_Radiation	Charged_Particles_Radiation	Alpha Radiation|Alpha Particle Radiation|Alpha-Radiation	An emission of positively charged particles composed of two protons and two neutrons, i.e., helium nuclei, emitted during disintegration of very heavy isotopes; a beam of alpha particles or an alpha ray has very strong ionizing power, but weak penetrability.
C16280	Alternate_Splicing	RNA_Splicing	Alternate Splicing|Alternative Splicing	Alternate Splicing is a process in which multiple protein isoforms or products are generated from a single gene as a result of splicing together different nonconsecutive exons during the processing of initially identical nascent transcripts of a gene into mature mRNA transcripts. An exon may be connected to any one of several alternative exons to form the mRNA and generate related proteins, often in a tissue or developmental stage specific manner.
C16281	Ambulatory_Care_Facility	Healthcare_Facility	Ambulatory Care Facility|Ambulatory Care Facilities|Clinic
C16282	American_Cancer_Society	Professional_Organization_or_Group	American Cancer Society|ACS	A nationwide, community-based voluntary health organization, the largest private source of cancer research funds in the U.S. Headquartered in Atlanta, Georgia, the ACS has state divisions and more than 3,400 local offices. ACS provides information on cancer incidence, mortality, causes, manifestations, treatment, and prevention, as well as on cancer research and clinical trials, and promotes beneficial policies, laws, and regulations for patients and families affected by cancer.
C16283	Native_American	Retired_Concepts	Native American|First Nations|Native Americans	A Native American (NA) is a person having origins in one of the indigenous peoples of North America, who lived on the continent prior to the European colonization. The term comprises individuals belonging to a large number of tribes, states, and ethnic groups, many of them still enduring as political communities.
C16284	Amylase	Hydrolase	Amylase|amylase	(AM-il-aze) An enzyme that helps the body digest starches.
C16285	Amyloid_Beta-A4_Protein_Precursor	Receptor	Amyloid Beta A4 Protein Precursor|AAA|ABPP|APP|APPI|Alzheimer Disease 1 Protein|Alzheimer's Disease Amyloid Protein|Amyloid|Amyloid Beta (A4) Precursor Protein|Amyloid Beta-Peptide|Amyloid of Aging and Alzheimer Disease Protein|CVAP|Cerebralvascular Amyloid Peptide|PN II|PN-II|PN2|PreA4|Protease Nexin II|Protease Nexin-II, Alzheimer Disease	Encoded by human APP Gene (APP Family), Amyloid Beta A4 Protein Precursor is an N-/O-glycosylated sulfated metal ion-binding type I cell surface protein containing a BPTI protease inhibitor domain. Widely expressed APP is processed by secretases into soluble peptides, membrane-anchored fragments, plaque amyloid components, and cytotoxic fragments. Phosphorylation by Casein Kinases, CDC5, CDC2, and MAPK10 can affect processing, interaction with Fe65, and SHC binding. A kinesin I membrane receptor for cell mobility, adhesion, and axonogenesis/synaptogenesis, APP variants inhibit Notch signaling, regulate copper homeostasis, bind lipoproteins, activate transcription, and enhance apoptosis via G(O) and JIP pathways. NPXY is required for binding protein PID domains, endocytosis, and BaSS sorting. APP defects cause Alzheimer's disease and cerebroarterial amyloidosis.
C16286	Anaphase	M-Phase_Substage	Anaphase|Mitotic Anaphase	The third phase of mitosis, in which the chromatids separate and migrate to opposite poles of the spindle.
C16287	Anatomical_Sciences	Biological_Sciences	Anatomical Sciences|Anatomy
C16288	Comparative_Anatomy	Anatomical_Sciences	Comparative Anatomy|Anatomy, Comparative
C16289	Andorra	Country	Andorra|020|AD|AN|AND	A country in Southwestern Europe, between France and Spain. (CIA World Factbook 2002)
C16290	Angiogram	Medical_Image	Angiogram|angiogram	(AN-jee-o-gram) An x-ray of blood vessels; the person receives an injection of dye to outline the vessels on the x-ray.
C16291	Digital_Subtraction_Angiography	Angiography	Digital Subtraction Angiography|Angiography, Digital Subtraction|Medical Imaging, Digital Subtraction Angiography
C16292	Angola	Country	Angola|024|AGO|AO	A country in Southern Africa, bordering the South Atlantic Ocean, between Namibia and Democratic Republic of the Congo. (CIA World Factbook 2002)
C16293	Animal_Husbandry	Agriculture	Animal Husbandry
C16294	Anthropology	Social_Sciences	Anthropology	The branch of science concerned with origin and development of humans in all their physical, social, and cultural relationships.
C16295	Antibody	Immunoprotein	Antibody|AB|Ab|Antibodies|antibody	(AN-tih-BOD-ee) A type of protein made by certain white blood cells in response to a foreign substance (antigen). Each antibody can bind to only a specific antigen. The purpose of this binding is to help destroy the antigen. Antibodies can work in several ways, depending on the nature of the antigen. Some antibodies destroy antigens directly. Others make it easier for white blood cells to destroy the antigen.
C16296	Anti-Idiotype_Antibody	Antibody	Anti-Idiotype Antibody|Anti-Anti-Idiotype|Antibody, Anti-Idiotypic	An antibody directed against the individual antigenic determinants (idiotopes) on the variable region of an immunoglobulin molecule.  In principle an anti-idiotype antibody should inhibit a specific immune response and they are important to the regulation of the immune system.
C16297	Avidity	Physical_Phenomena_or_Properties	Avidity	Strength of binding, usually of a small molecule with multiple binding sites by a larger, particularly the binding of a complex antigen by an antibody. (On-line Medical Dictionary)
C16298	Antibody-Dependent_Cellular_Cytotoxicity	Cell-Mediated_Cytolysis	Antibody-Dependent Cellular Cytotoxicity|ADCC	Antibody-dependent target cell killing by a killer cell.  An antibody is directed to the target by antigen-binding arms and anchors to the killer cell by an Fc receptor.  Antibody-mediated target cell destruction by non-sensitized effector cells.  The identity of the target cell varies, but it must possess surface IgG whose Fc portion is intact.  The effector "killer" cell possesses Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.
C16299	Anticoagulation	Coagulation_Process	Anticoagulation	Anticoagulation - the process of hindering the clotting of blood, particularly, by the administration of an anticoagulant drug to stunt coagulation.(NCI)
C16300	CD4_Antigen	Cell_Adhesion_Molecule	CD4 Antigen|CD4|CD4 Antigen (P55)|CD4 Protein|OKT4 Antigen|T-Cell Antigen T4/Leu3|T-Cell Surface Antigen T4/Leu-3	CD4 Antigen, encoded by the CD4 gene, is a T-cell surface glycoprotein. CD4 has a role in cell-cell interactions and may act in signal transduction. CD4 is a accessory protein for MHC class-II antigen/T-cell receptor interaction and functions to initiate or augment the early phase of T-cell activation. CD4 enhances T-cell sensitivity to antigen and binds to LCK, which phosphorylates CD3-zeta. CD4 Antigen also serves as an HIV receptor, binding directly to the envelope protein gp120 on HIV. (From LocusLink, OMIM and NCI)
C16301	Differentiation_Antigen	Biomarker	Differentiation Antigen	antigens normally only seen at particular phases of differentiation of a cell type.
C16302	T-Antigen	Viral_Protein	T-Antigen|T-Antigens	Proteins encoded by the genomes of specific DNA tumor viruses that are associated with the neoplastic transformation of infected cells. T-antigens stimulate the production of antibodies and are immunogenic.
C16303	Antigua_and_Barbuda	Country	Antigua and Barbuda|028|AC|AG|ATG	Islands between the Caribbean Sea and the North Atlantic Ocean, east-southeast of Puerto Rico. (CIA World Factbook 2002)
C16304	Architecture	Technology	Architecture|Engineering / Architecture	The art or science of building; especially, the art of building houses, churches, bridges, and other structures, for the purposes of civil life
C16305	Argentina	Country	Argentina|032|AR|ARG	A country in Southern South America, bordering the South Atlantic Ocean, between Chile and Uruguay. (CIA World Factbook 2002)
C16306	Armenia	Country	Armenia|051|AM|ARM	A country in Southwestern Asia, east of Turkey. (CIA World Factbook 2002)
C16307	Aromatase	Protein_or_Riboprotein_Complex	Aromatase|EC 1.14.14.1	A p450-like enzyme, Aromatase catalyzes, with an NADPH-linked reductase, the oxidative aromatization of androgens to estrogens. Expressed in gonads, palcenta and brain, Aromatase and NADPH-cytochrome P450 reductase (reductase) are both highly conserved, essential components of the enzyme complex and essential for reproductive development and fertility.
C16308	Arteriography	Angiography	Arteriography|arteriography	(ar-TEE-ree-AH-gra-fee) A procedure to x-ray arteries. The arteries can be seen because of an injection of a dye that outlines the vessels on an x-ray.
C16309	Artificial_Intelligence	Computer_Sciences	Artificial Intelligence	Artificial intelligence is the branch of computer science that deals with writing computer programs that can solve problems creatively.
C16310	Asian_American	Race	Asian American|Asian Americans	Asian American - a person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent, and who was either born in the United States or who was naturalized as a citizen of the United States. The concept refers also to individuals who classify themselves as described below.
C16311	Australia	Country	Australia|036|AS|AU|AUS	The continent between the Indian Ocean and the South Pacific Ocean. (from CIA World Factbook 2002)
C16312	Austria	Country	Austria|040|AT|AU|AUT	A country in Central Europe, north of Italy and Slovenia. (CIA World Factbook 2002)
C16313	Autoimmune_Process	Pathologic_Process	Autoimmune Process|Autoimmune	Developmentally complex, not necessarily pathological, and possibly pervasive, an Autoimmune Process is a specific humoral or cell-mediated immune response against autologous (self) antigens.  An autoimmune process may produce or be caused by autoimmune disease.
C16314	Autoradiography	Imaging_Technique	Autoradiography	A technique that uses X- ray film to locate radioactively labeled molecules or fragments of molecules by recording on a photographic plate the radiation emitted by radioactive material within the object.
C16315	Award	Conceptual_Entities	Award|Awards	Award; a prize given for achievement in a specific area.
C16316	Azerbaijan	Country	Azerbaijan|031|AJ|AZ|AZE	A country in Southwestern Asia, bordering the Caspian Sea, between Iran and Russia. (CIA World Factbook 2002)
C16317	B16_Malignant_Melanoma	Experimental_Malignant_Melanoma	B16 Malignant Melanoma|B16 Melanoma
C16318	Low-Level_Radiation	Electromagnetic_Radiation	Low-Level Radiation|Background Radiation
C16319	Bacterial_Protein	Non-Human_Protein	Bacterial Protein	Proteins that originated from bacteria sources.
C16320	Bacteriology	Microbiology	Bacteriology	The branch of science that studies bacteria, especially in relation to medicine and agriculture.(NCI)
C16321	Bahamas	Country	Bahamas|044|BF|BHS|BS	A chain of islands in the North Atlantic Ocean, southeast of Florida. (CIA World Factbook 2002)
C16322	Bahrain	Country	Bahrain|048|BA|BH|BHR	An archipelago in the Persian Gulf, east of Saudi Arabia. (CIA World Factbook 2002)
C16323	Bangladesh	Country	Bangladesh|050|BD|BG|BGD	A country in Southern Asia, bordering the Bay of Bengal, between Burma and India. (CIA World Factbook 2002)
C16324	Barbados	Country	Barbados|052|BB|BRB	An island between the Caribbean Sea and the North Atlantic Ocean, northeast of Venezuela. (CIA World Factbook 2002)
C16325	BCR-ABL_Oncoprotein	Oncoprotein	BCR-ABL Oncoprotein|BCR ABL Fusion Protein|BCR-ABL Protein Tyrosine Kinase|BCR/ABL	An onco-protein generated from the fusion of Bcr and Abl genes by translocation process between chromosome 9 and 22 (Philadelphia chromosome), in CML (P210) and some ALL (P190).
C16326	Behavior	Social_Concepts	Behavior|Conduct	The actions or reactions of an object or organism, usually in relation to the environment or surrounding world of stimuli.
C16327	Behavioral_Medicine	Medicine|Population_Sciences	Behavioral Medicine	The study, prevention, and treatment of medical and psychosomatic disorders and of undesirable behaviors, such as overeating and substance abuse, by the application of behavior therapy techniques, such as biofeedback, relaxation training, and hypnosis.
C16328	Behavioral_Sciences	Occupation_or_Discipline	Behavioral Sciences	Disciplines concerned with the study of human and animal behavior, such as psychology, sociology, and anthropology.
C16329	Belgium	Country	Belgium|056|BE|BEL	A country in Western Europe, bordering the North Sea, between France and the Netherlands. (CIA World Factbook 2002)
C16330	Belief_System	Social_Concepts	Belief System
C16331	Belize	Country	Belize|084|BH|BLZ|BZ	A country in Central America, bordering the Caribbean Sea, between Guatemala and Mexico. (CIA World Factbook 2002)
C16333	Benin_Republic	Country	Benin Republic|204|BEN|BJ|BN|Benin	A country in Western Africa, bordering the North Atlantic Ocean, between Nigeria and Togo. (CIA World Factbook 2002)
C16334	Bermuda	Country	Bermuda|060|BD|BM|BMU|Bermuda Islands|Bermudas	A group of islands in the North Atlantic Ocean, east of South Carolina. (from CIA World Factbook)
C16335	Beta_Globulin	Serum_Globulin	Beta Globulin	A type of globulin in plasma that in electrically charged solutions exhibits colloidal mobility between that of the alpha and gamma globulins.
C16336	Bhutan	Country	Bhutan|064|BT|BTN	A country in Southern Asia, between China and India. (CIA World Factbook 2002)
C16337	Biochemistry	Biological_Sciences	Biochemistry|Chemistry, Biological	The study of the chemical substances and vital processes occurring in living organisms.
C16338	Biomaterials	Drugs_and_Chemicals	Biomaterial|Biomaterials	A biocompatible material that is used to construct artificial organs, rehabilitation devices, or prostheses and replace natural body tissues. (Dictionary.com)
C16339	Bioelectric_Energy_Sources	Medical_Device	Bioelectric Energy Sources	Implantable devices which convert biological energy (chemical energy of the metabolism of continuously regenerating body fluids or mechanical energy of periodic movements) to electrical energy. The sources include biogalvanic cells, biofuel cells, and ionic concentration cells.
C16340	Biomedical_Ethics	Ethics	Biomedical Ethics|Bioethics	The branch of ethics that studies moral values in the biomedical sciences.
C16341	Bioassay	Biological_Testing	Bioassay|Assay|assay	(AS-say) A laboratory test to find and measure the amount of a specific substance.
C16342	Biomarker	Diagnostic_or_Prognostic_Factor	Biomarker|Biological Marker|Biological Markers|Biomarkers|MARK|Marker|Molecular Marker|Signature Molecule|biomarkers|marker	Objectively measurable phenotypic parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype, presence of biological substances) that characterize an organism's state of health or disease, likelihood of developing a disease, or response to a particular therapeutic intervention.
C16343	Psychobiology	Biological_Sciences	Psychobiology|Biological Psychiatry	The study of the interrelationships of the biology and psychology in cognitive functioning, including intellectual, memory, and related neurocognitive processes. (On-line Medical Dictionary)
C16344	Biological_Sciences	Occupation_or_Discipline	Biological Sciences
C16345	Biology	Biological_Sciences	Biology	science concerned with the phenomena of life and living organisms.
C16346	Biomechanics	Biophysics	Biomechanics	The study of the mechanics of a living body, especially of the forces exerted by muscles and gravity on the skeletal structure.
C16347	Biostatistics	Statistics	Biostatistics|Biometrics|Biometry|Biometry and Biostatistics|Biometry and Statistics	Measurement of life; calculation of the probable duration of human life. (On-Line Medical Dictionary)
C16348	Biological_Rhythm	Organismal_Process	Biological Rhythm|Biological Rhythm and Oscillation	A biologically inherent cyclic variation or recurrence of an event or state, such as the sleep cycle, circadian rhythms, or periodic diseases. (NCI)
C16349	Biophysics	Biological_Sciences	Biophysics	Biophysics; physics as applied to biological problems; an interdisciplinary science that applies theories and methods of the physical sciences to questions of biology. (from Wikipedia)
C16350	Biosensors	Biotechnology	Biosensors	The coupling of a biological material (for example, enzyme, receptor, antibody, whole cell, organelle) with a microelectronic system or device to enable rapid, accurate, low level detection of various substances in body fluids, water, and air. (On-line Medical Dictionary)
C16351	Biotechnology	Technology	Biotechnology	The field devoted to applying the techniques of biochemistry, cellular biology, biophysics, and molecular biology to addressing issues related to human beings and the environment.
C16352	African_American	Race	African American|Afro American|Black|Black Populations|Black or African American	African American; term used in the United States to categorize a population group comprised of persons having origins in any of the black racial groups of Africa, most of whose ancestors were brought from Africa to the Americas as slaves between the sixteenth and nineteenth centuries. Includes population subgroups, e.g. Kenyan, Nigerian, or Haitian. The concept refers also to individuals who classify themselves as described.
C16353	Blood_Circulation	Circulatory_Process	Blood Circulation|Blood Flow|Bloodstream|Circulation	The movement of blood to and from the heart and to the rest of the body's organs, tissues, and cells through the network of arteries, veins, and capillaries. (NCI)
C16354	Coagulation_Factor	Ligand_Binding_Protein	Coagulation Factor|Blood Coagulation Factor|Clotting Factor	Factors in the blood that are essential for blood coagulation. The absence or mutation of these factors can lead to hemophilia and blood clotting disorders.
C16355	Northern_Blotting	Nucleic_Acid_Hybridization|RNA_Analysis	Northern Blot|Blotting, Northern	A common molecular biology technique for detection of RNA molecules.  RNA extracted from a sample was denatured and separated by slab gel electrophoresis, then blotted on to a nitrocellulose or nylon sheet and hybridized with labeled DNA or RNA that is complementary to the desired RNA, whose presence is subsequently indicated by autoradiography or other visualization techniques.
C16356	Blotting_Southern	DNA_Analysis|Nucleic_Acid_Hybridization	Blotting, Southern|Southern Blot	A technique for detection of specific DNA fragments. Restriction fragments are separated by polyacrylamide-gel electrophoresis, blotted on to a plastic sheet (e.g. of nitrocellulose) and detected by hybridization with a radiolabelled probe followed by autoradiography. (from DM Glick: Glossary of Biochemistry and Molecular Biology (1996).)
C16357	Blotting_Western	Immunologic_Techniques|Protein_Analysis	Blotting, Western|Western Blotting	Identification of proteins or peptides that have been separated by gel electrophoresis and transferred (blotted) to strips of nitrocellulose paper. The blots are then detected by enzymatically labelled or radiolabeled antibody probes.
C16358	Body_Mass_Index	Personal_Attribute	Body Mass Index|BMI	Body Mass Index (BMI) is a general indicator of the body fat an individual is carrying based upon the ratio of weight to height.
C16359	Bolivia	Country	Bolivia|068|BL|BO|BOL	A country in Central South America, southwest of Brazil. (CIA World Factbook 2002)
C16360	Book	Document_Type	Book	A volume made up of pages fastened along one edge and enclosed between protective covers. (from American Heritage Dictionary)
C16361	Bosnia-Herzegovina	Country	Bosnia-Herzegovina|070|BA|BIH|BK|Bosnia and Herzegovina	A country in Southeastern Europe, bordering the Adriatic Sea and Croatia. (CIA World Factbook 2002)
C16362	Botany	Biology	Botany	Botany; the branch of biology that studies plants.
C16363	Botswana	Country	Botswana|072|BC|BW|BWA	A country in Southern Africa, north of South Africa. (CIA World Factbook 2002)
C16364	Brazil	Country	Brazil|076|BR|BRA	A country in Eastern South America, bordering the Atlantic Ocean. (CIA World Factbook 2002)
C16365	British_Indian_Ocean_Territory	Country	British Indian Ocean Territory|086|IO|IOT	An archipelago in the Indian Ocean, about one-half the way from Africa to Indonesia. (CIA World Factbook 2002)
C16366	Bronchoscopy	Endoscopy	Bronchoscopy|bronchoscopy	(bron-KOS-ko-pee) A procedure in which a thin, lighted tube is inserted through the nose or mouth. This allows examination of the inside of the trachea and bronchi (air passages that lead to the lung), as well as the lung. Bronchoscopy may be used to detect cancer or to perform some treatment procedures.
C16367	Brunei	Country	Brunei|096|BN|BRN|BX	A country in Southeastern Asia, bordering the South China Sea and Malaysia. (CIA World Factbook 2002)
C16368	Bulgaria	Country	Bulgaria|100|BG|BGR|BU	A country in Southeastern Europe, bordering the Black Sea, between Romania and Turkey. (CIA World Factbook 2002)
C16369	Burkina_Faso	Country	Burkina Faso|854|BF|BFA|UV	A country in Western Africa, north of Ghana. (CIA World Factbook 2002)
C16370	Myanmar	Country	Myanmar|104|BM|Burma|MM|MMR|Union of Myanmar	A country in Southeastern Asia, bordering the Andaman Sea and the Bay of Bengal, between Bangladesh and Thailand. (CIA World Factbook 2002)
C16371	Burundi	Country	Burundi|108|BDI|BI|BY	A country in Central Africa, east of Democratic Republic of the Congo. (CIA World Factbook 2002)
C16372	Belarus	Country	Belarus|112|BLR|BO|BY|Byelarus	A country in Eastern Europe, east of Poland. (CIA World Factbook 2002)
C16373	Cadherin	Cell_Adhesion_Molecule	Cadherin	The cadherins are transmembrane glycoproteins involved in calcium dependent specific cell-cell adhesion through homophilic binding. They are crucial for morphogenesis and synapse formation, but also are involved in tumor invasion. The classical cadherins have five homologous extracellular domains and a cytosolic domain which binds through catenin to the cytoskeleton. The extracellular domains are immunoglobulin-like beta-sandwiches comprising usually 7 strands in the two sheets.
C16374	Calcium_Channel	Ion_Channel	Calcium Channel
C16375	Calmodulin	Calcium_Binding_Protein	Calmodulin|CALM|CALM1|CALM2|CAM|CAM1|Calmodulin 1|Calmodulin 1 (Phosphorylase Kinase, Delta)	Calmodulin 1, encoded by the CALM1 gene, is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin 1 binds calcium and regulates proteins and enzymes in a calcium-dependent manner. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Ubiquitination strongly decreases its activity. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters. (From LocusLink, Swiss_Prot)
C16376	Mitogen-Activated_Protein_Kinase	Serine-Threonine_Protein_Kinase	Mitogen-Activated Protein Kinase|EC 2.7.2-|ERK|Extracellular Signal-Regulated Kinases|MAPK|Map Kinase	Mitogen-activated protein kinases (MAPKs) are serine-threonine protein kinases activated in response to a variety of extracellular stimuli and encoded by a multigene family. The MAPKs are part of complex protein kinase cascades. One of the several classes of MAPKs includes (among other ERKs) the extracellular signal-regulated kinases ERK1 (p44MAPK) and ERK2 (p42MAPK), activated by the RAF/MEK/ERK signaling pathway. ERK1/2 are widely involved in eukaryotic signal transduction. Upon activation, ERKs translocate to the nucleus and phosphorylate nuclear targets. Phosphorylated ERKs form essential dimers with phosphorylated and unphosphorylated ERK partners. Dimerization is part of the mechanism of MAP kinase family action. Mitogen-activated protein kinases (MAPKs) promote entry in the cell cycle.  (from OMIM 601795, 176948, Swiss-Prot P27361, P28482 and NCI)
C16377	Calpain	Cysteine_Proteinase	Calpain|Papain-Like Cysteine Protease	A class of calcium-dependent thiol-proteases that proteolytically cleave a wide variety of cytoskeletal, membrane-associated, and regulatory proteins. There are two main isoforms of the protein, which differ in their calcium requirement for activation. These enzymes have been linked to both acute and chronic neurodegenerative processes, such as: ischemia, trauma, and Alzheimer's disease.
C16378	Cambodia	Country	Cambodia|116|CB|KH|KHM|Kampuchea	A country in Southeastern Asia, bordering the Gulf of Thailand, between Thailand, Vietnam, and Laos. (CIA World Factbook 2002)
C16379	Cameroon	Country	Cameroon|120|CM|CMR	A country in Western Africa, bordering the Bight of Biafra, between Equatorial Guinea and Nigeria. (CIA World Factbook 2002)
C16380	Canada	Country	Canada|124|CA|CAN	A country in Northern North America, bordering the North Atlantic Ocean on the east, North Pacific Ocean on the west, and the Arctic Ocean on the north, north of the conterminous US. (CIA World Factbook 2002)
C16381	Canton_and_Enderbury_Islands	Retired_Concepts	Canton and Enderbury Islands
C16382	Cape_Verde	Country	Cape Verde|132|CPV|CV	A group of islands in the North Atlantic Ocean, west of Senegal. (CIA World Factbook 2002)
C16383	Capsid_Protein	Viral_Protein	Capsid Protein|Capsid	The outer protective shell of a virus. The structure of the shell is icosahedral with either helical or complex symmetry. Capsid proteins surround and protect the viral nucleic acid core.
C16384	CD66E_Antigen	Protein_with_Unknown_or_Unclassified_Function	Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5|CD66e Antigen|CEA|CEACAM5|Carcinoembryonic Antigen|Carcinoembryonic Antigen CGM2|Meconium Antigen 100	An antigen that is secreted onto the luminal surface of gastrointestinal epithelia and is found in pancreaticobiliary secretions. The antigen has been implicated as a facilitator of hepatic metastasis and is a cancer specific antigen of colon carcinoma. It is present in adenocarcinomas of endodermal origin and is localized in human embryonic gastrointestinal tissue.
C16385	Cardiovascular_Physiology	Physiology	Cardiovascular Physiology	Study of the functions and activities of the cardiovascular system as a whole or of any of its parts.
C16386	Transport_Protein	Ligand_Binding_Protein	Transport Protein|Carrier Protein|Transporter Protein	Proteins that carry specific substances in the blood or across cell membranes.
C16387	Catechol-O-Methyltransferase	Methyltransferase	Catechol O-Methyltransferase|COMT|EC 2.1.1.6	the catechol-O-methyltransferase (COMT) pathway is essential for preventing the generation of estrogen derived reactive oxygen species. (from Thorax 2000;55:574-578)
C16388	Cathepsin-D	Cathepsin	Cathepsin D|CTSD|Cathepsin D (Lysosomal Aspartyl Protease)|EC 3.4.23.5	Cathepsin D, encoded by the CTSD Gene, is a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It has a specificity similar to but narrower than that of pepsin A, decomposing cytoplasmic proteins, cell organelles, collagen, elastase and proteoglycans. Cathepsin D takes part in angiogenesis and activates osteoclasts, and plays a major role in the destruction of bone tissue by cholesteatoma. Transcription of the CTSD gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast and ovarian cancer, and possibly Alzheimer disease. (From LocusLink, PMID 12185597 and NCI)
C16389	Cathepsin	Protease	Cathepsin|Cathepsins	Lysosomal proteinases or endopeptidases that function optimally at an acidic pH to catalyze the hydrolysis of peptidic bonds. Elevated cathepsin enzyme activity in either serum or extracellular matrix is often indicative of pathological conditions such as Alzheimer's disease, several types of cancer, arthritis, and osteoporosis.
C16390	Etiology	Medicine	Etiology|etiology	Etiology is the study of causation. In medicine it specifically refers to the causation of diseases or pathologies. (from Wikipedia)
C16391	Cayman_Islands	Country	Cayman Islands|136|CJ|CYM|KY	An island group in the Caribbean Sea, nearly one-half of the way from Cuba to Honduras. (CIA World Factbook 2002)
C16392	Cell_Adhesion	Cell_Adhesion_Process	Cell Adhesion|Cellular Adhesion|cellular adhesion	Cell Adhesion involves close adherence (bonding) of a cell to another cell surface or to insoluble material due to physiochemical attraction between molecules on the surfaces of the adjoining bodies in contact.
C16393	Cell_Adhesion_Molecule	Ligand_Binding_Protein	Cell Adhesion Molecule|Adhesion Molecule|CAM|CAMs	A diverse family of cell surface and extracellular glycoproteins involved in cell-cell and cell-extracellular matrix adhesion, recognition, and activation. There are four main classes of cell adhesion molecules: integrins, selectins, cafherins, and immunoglobulin-like adhesion molecules.
C16394	Cell_Aging	Cellular_Process	Cell Aging|Aging, Cellular|Cell Senescence|Cellular Aging|Cellular Senescence	Progression of the cell from its inception to the end of its lifespan. (Gene Ontology)
C16395	Intercellular_Communication	Intercellular_Communication_Process	Intercellular Communication|Cell to Cell Communication and Signaling|Cell-Cell Signaling	An information exchange between living cells through direct cell contacts or by extracellular chemical signals. Cell signaling allows cell populations to maintain homeostatic balance and enable healthy cells and tissue to respond to external stimuli. This balance is frequently disrupted in cancerous or tumorigenic cells.
C16396	Cell_Culture	Tissue_Culture	Cell Culture|cultured cells	Animal or human cells that are grown in the laboratory.
C16397	Cell_Cycle	Cell_Division_Process	Cell Cycle|Cell Growth/Cell Cycle|Mitotic Cell Cycle	The complex series of phenomena, occurring between the end of one cell division and the end of the next, by which cellular material is divided between daughter cells.  The cell cycle is an ordered set of events, culminating in cell growth and division into two daughter cells.  The stages of cell cycle includes G1-S-G2-M.  The G1 stage stands for "GAP 1".  The S stage stands for "Synthesis".  This is the stage when DNA replication occurs.  The G2 stage stands for "GAP 2".  The M stage stands for "mitosis", and is when nuclear (chromosomes separate) and cytoplasmic (cytokinesis) division occur.
C16398	Cell_Death	Cell_Death_Process	Cell Death	The termination of the cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
C16399	Cell_Differentiation	Cell_Differentiation_Process	Cell Differentiation|Differentiation|cell differentiation	Progressive restriction of the developmental potential and increasing specialization of function which takes place during the development of the embryo and leads to the formation of specialized cells, tissues, and organs.
C16400	Cell_Division	Cell_Division_Process	Cell Division	Cell Division involves the production of separate daughter cells from a precursor cell by division of the nucleus (mitosis) in eukaryotes and division of the cytoplasm (cytokinesis).
C16401	Cell_Fusion	Cytological_Techniques	Cell Fusion|Cell Biology, Cell Fusion	A technique to form a single hybrid cell, by fusion of two or more dissimilar cells, either spontaneously or by induced fusion. The cells fuse and coalesce, but their nuclei may remain separated.  The cell fusion technique can be used as a method of assigning genes to specific chromosomes.
C16402	Cell_Growth	Cell_Growth_Process	Cell Growth|Cellular Expansion|Cellular Growth	The complex series of phenomena occurring after cell division and before cell death.
C16403	Cell_Line	Specimen	Cell Line|cultured cell line	A permanently established cell culture that will proliferate indefinitely given appropriate fresh medium and space. (On-line Medical Dictionary)
C16404	Cell_Motility	Cell_Movement	Cell Motility|Motility|Motility, Cellular|cell motility	Cell Motility consists of active translocation of a whole cell, or cell body, from one site to another; distinct from cell motion that involves movement of cell processes (e.g., axons, microvilli, etc.). (NCI)
C16405	Cell_Physiology	Cell_Biology	Cell Physiology|Cellular Function|Cellular Physiology	Characteristics and physiological processes of cells from cell division to cell death. (On-line Medical Dictionary)
C16406	Cell_Sorting	Cytological_Techniques	Cell Sorting|Cell Separation Technology	Techniques and methods for separating cells (usually viable) based on a variety of criteria for separation, such as size or density, non-specific surface properties, or specific surface properties.  Examples include cell affinity chromatography and centrifugation using density gradients.
C16407	Cell_Survival	Cell_Viability_Process	Cell Survival	A process that encompasses the viability of a cell and its ability to subsist and maintain the integrity of cellular processes. Survival mechanisms ensure that the cell will be able to adapt and carry on cellular activities such as replication, repair, and metabolism.
C16408	Centers_for_Disease_Control_and_Prevention	Other_Agency_or_Organization	Centers for Disease Control and Prevention|CDC	The CDC serves as the national focus for developing and applying disease prevention and control, environmental health and health promotion and health education activities designed to improve the health of the people of the United States. The CDC is responsible for controlling the induction and spread of infectious diseases, and provides consultation and assistance to other nations and international agencies to assist in improving their disease prevention and control, environmental health, and health promotion activities. (from Department of Health and Human Services Omnibus Solicitation of the Public Health Service for SBIR)
C16409	Central_African_Republic	Country	Central African Republic|140|CAF|CF|CT	A country in Central Africa, north of Democratic Republic of the Congo. (CIA World Factbook 2002)
C16410	Centrifugation	Biomolecule_Separations_Technology	Centrifugation|Fractionation, Centrifugation	Process of using a rotating machine to generate centrifugal force to separate substances of different densities, remove moisture, or simulate gravitational effects. It employs a large motor-driven apparatus with a long arm, at the end of which human and animal subjects, biological specimens, or equipment can be revolved and rotated at various speeds to study gravitational effects. (From Websters, 10th ed; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
C16411	Density_Gradient_Centrifugation	Centrifugation	Density Gradient Centrifugation|Fractionation, Density Gradient	A method of separating macromolecules by either their differential rate of sedimentation in a centrifugal gradient or their differential buoyancy in a density gradient. (from biology-text.com)
C16412	Chad	Country	Chad|148|CD|TCD|TD	A country in Central Africa, south of Libya. (CIA World Factbook 2002)
C16413	Chemical_Engineering	Engineering	Chemical Engineering	Chemical Engineering; engineering dealing with the industrial application of chemistry. (WWWebster Dictionary)
C16414	Chemistry	Physical_Sciences	Chemistry|CHEM	The science of the composition, structure, properties, and reactions of matter, especially of atomic and molecular systems.
C16415	Analytical_Chemistry	Chemistry	Analytical Chemistry|Chemistry, Analytical	The branch of chemistry that deals with the quantitative and qualitative identification of substances. (On-line Medical Dictionary)
C16416	Bioinorganic_Chemistry	Biochemistry|Inorganic_Chemistry	Bioinorganic Chemistry
C16417	Clinical_Chemistry	Analytical_Chemistry|Clinical_Sciences	Clinical Chemistry	The department responsible for performing chemical and enzymatic analyses of body fluids and tissues. (from Handbook of Medical Informatics)
C16418	Inorganic_Chemistry	Chemistry	Inorganic Chemistry
C16419	Organic_Chemistry	Chemistry	Organic Chemistry	A branch of chemistry that deals specifically with the structures, synthesis and reactions of carbon-containing compounds.
C16420	Medicinal_Chemistry	Pharmacology	Medicinal Chemistry|Pharmaceutical Chemistry	Medicinal chemistry is a chemistry-based discipline, also involving aspects of biological, medical and pharmaceutical sciences. It is concerned with the invention, discovery, design, identification and preparation of biologically active compounds, the study of their metabolism, the interpretation of their mode of action at the molecular level and the construction of structure-activity relationships. (Glossary of Terms Used in Medicinal Chemistry)
C16421	Physical_Chemistry	Chemistry	Physical Chemistry|Chemistry, Physical	The branch of chemistry dealing with the physical properties of chemical substances. Chemical thermodynamics, chemical kinetics, quantum chemistry, statistical mechanics, and spectroscopy are some areas of chemistry comprising the bulk of physical chemistry. (from Wikipedia)
C16422	Chemotaxis	Cell_Migration	Chemotaxis	The characteristic movement or orientation of an organism or cell along a chemical concentration gradient either toward or away from the chemical stimulus.
C16423	Children	Age_Group	Child|Children|Children (0-21)	A person who is not yet an adult.  The specific cut-off age will vary by purpose.
C16424	Child_Abuse_and_Neglect	Other_Finding	Child Abuse and Neglect	The psychological, emotional, and sexual abuse of a child, typically by a parent, stepparent, or parent surrogate.
C16425	Child_Psychiatry	Psychiatry	Child Psychiatry	A subdiscipline of psychology centered on the special mental health needs of non-adults.
C16426	Developmental_Psychology_Child	Developmental_Psychology_General	Developmental Psychology, Child
C16427	Chile	Country	Chile|152|CHL|CI|CL	A country in Southern South America, bordering the South Atlantic Ocean and South Pacific Ocean, between Argentina and Peru. (CIA World Factbook 2002)
C16428	China	Country	China|156|CH|CHN|CN	A country in Eastern Asia, bordering the East China Sea, Korea Bay, Yellow Sea, and South China Sea, between North Korea and Vietnam. (CIA World Factbook 2002)
C16429	Chloramphenicol-O-Acetyltransferase	Bacterial_Protein	Chloramphenicol O-acetyltransferase|CAT|CAT I|CAT II|CAT III|Chloramphenicol Acetyl Transferase|Chloramphenicol Transacetylase|EC 2.3.1.28	Bacterial chloramphenicol-O-acetyltransferase protein (219 aa, 26 kD) is encoded by the bacterial chloramphenicol-O-acetyltransferase (cat) gene. This enzyme detoxifies the antibiotic chloramphenicol via acetylation to yield chloramphenicol 3-acetate. The presence of this enzyme confers chloramphenicol resistance to bacteria, which is used as a marker for selection in molecular techniques that utilize genetic transfection.
C16430	Endoscopic_Retrograde_Cholangiopancreatography	Endoscopy	Endoscopic Retrograde Cholangiopancreatography|ERCP|endoscopic retrograde cholangiopancreatography	(en-dah-SKAH-pik RET-ro-grade ko-LAN-jee-o-PAN-kree-a-TOG-ra-fee) ERCP. A procedure to x-ray the pancreatic duct, hepatic duct, common bile duct, duodenal papilla, and gallbladder. In this procedure, a thin, lighted tube (endoscope) is passed through the mouth and down into the first part of the small intestine (duodenum). A smaller tube (catheter) is then inserted through the endoscope into the bile and pancreatic ducts. A dye is injected through the catheter into the ducts, and an x-ray is taken.
C16431	Chromatography	Biomolecule_Separations_Technology	Chromatography|Chromatography / Separation Science	A technique for the separation of complex mixtures that relys on the differential affinities of substances for a gas or liquid mobile medium and for a stationary adsorbing medium through which they pass.
C16432	Affinity_Chromatography	Column_Chromatography	Affinity Chromatography	A chromatographic separation technique based on the ability of proteins to bind specific ligands reversibly.
C16433	Gel_Filtration_Chromatography	Column_Chromatography	Gel Filtration Chromatography	Gel permeation or sieve chromatography.  Chromatography performed on porous gels that separate solutes on the basis of size: smaller solutes are included within the particles of the gel matrix more frequently than larger solutes.
C16434	High_Performance-Liquid_Chromatography	Liquid_Chromatography	High Performance-Liquid Chromatography|HPLC	Frequently referred to simply as HPLC, this form of column chromatography is used frequently in biochemistry. The analyte is forced through a column by liquid at high pressure, which decreases the time the separated components remain on the stationary phase. Less time on the column then translates to narrower peaks in the resulting chromatogram and thence to better selectivity and sensitivity. (from Wikipedia)
C16435	Liquid_Chromatography	Column_Chromatography	Liquid Chromatography|LC	A type of chromatography in which separation of a mixture is achieved by passing a sample in a stream of liquid solvent through some form of material that will provide resistance by virtue of chemical interactions between the components of the sample and the material.
C16436	Chromogranin	Serum_Protein	Chromogranin|CHG	Chromogranins are acidic secretory glycoproteins with a widespread but specific distribution in neuroendocrine tissues. The chromogranin family is heterogenous, consisting of propeptides such as chromogranin-A, chromogranin-B and secretogranin II, which can either elicit an effect themselves, or serve as precursors to a large number of peptides, which are biologically more active.
C16437	Chromosome_Banding	Cytogenetic_Analysis	Chromosome Banding	The treatment of chromosomes to reveal characteristic patterns of horizontal bands.  The banding patterns lend each chromosome a distinctive appearance so the 22 pairs of human nonsex chromosomes and the X and Y chromosomes can be identified and distinguished without ambiguity. Banding also permits the recognition of chromosome deletions (lost segments), chromosome duplications (surplus segments) and other types of structural rearrangements of chromosomes. (MedicineNet.com)
C16438	Gene_Mapping	Genetic_Techniques	Gene Mapping|Gene Localization|Gene Mapping, Total Human and Non-Human|Genetic Mapping|Genetics, Gene Mapping	Determination of the relative positions of genes on a DNA molecule (chromosome or plasmid) and of the distance, in linkage units or physical units, between them. (On-line Medical Dictionary)
C16439	Clinical_Informatics	Informatics	Clinical Informatics
C16440	Clinical_Medicine	Clinical_Sciences|Medicine	Clinical Medicine|Medical Sciences, Clinical	The practice of medicine based on direct observation of patients.
C16441	Cell_Clone	Clone	Cell Clone
C16442	Cloning	Molecular_Biology_Techniques	Cloning	Any of the techniques that produce identical individuals.
C16443	Gene_Cloning	Cloning	Gene Cloning|Molecular Biology, Gene Cloning	The insertion of a DNA sequence into a vector that can then be propagated in a host organism, generating a large number of copies of the sequence. (On-line Medical Dictionary)
C16444	Cloudman_S91_Malignant_Melanoma	Experimental_Malignant_Melanoma	Cloudman S91 Malignant Melanoma|Cloudman S91 Melanoma	A transplantable melanoma that arose spontaneously in a mouse of DBA strain, and which grows and metastasizes in mice of related strains. (dictionarybarn.com)
C16445	Cocos_Keeling_Islands	Country	Cocos (Keeling) Islands|166|CC|CCK|CK	A group of islands in the Indian Ocean, south of Indonesia, about halfway from Australia to Sri Lanka. (CIA World Factbook 2002)
C16446	Cognition	Mental_Process	Cognition	1. Generic term embracing the mental activities associated with thinking, learning, and memory. 2. Any process whereby one acquires knowledge.
C16447	Collagen	Extracellular_Matrix_Protein	Collagen|collagen	A fibrous protein found in cartilage and other connective tissue.
C16448	Collagen-IV	Collagen	Collagen IV|Collagen Type IV	The major structural component of basement membranes, Collagen-IV consists of six subunits encoded by genes COL4A1, COL4A2, COL4A3, COL4A4, COL4A5 and COL4A6.
C16449	Colombia	Country	Colombia|170|CO|COL	A country in Northern South America, bordering the Caribbean Sea, between Panama and Venezuela, and bordering the North Pacific Ocean, between Ecuador and Panama. (CIA World Factbook 2002)
C16450	Colonoscopy	Endoscopy	Colonoscopy|colonoscopy	(ko-lun-AHS-ko-pee) An examination of the inside of the colon using a thin, lighted tube (called a colonoscope) inserted into the rectum. If abnormal areas are seen, tissue can be removed and examined under a microscope to determine whether disease is present.
C16451	Colposcopy	Endoscopy	Colposcopy|colposcopy	(kul-PAHS-ko-pee) Examination of the vagina and cervix using a lighted magnifying instrument called a colposcope.
C16452	Communication	Behavior	Communication	the exchange of information between objects, people, or groups.
C16453	Community	Conceptual_Entities	Community	Community is a set of people with some shared element. The substance of shared element varies widely, from geography to a situation to interest to lives and values. The term is widely used to evoke sense of collectivity. (from Wikipedia)
C16454	Community_Health_Center	Healthcare_Facility	Community Health Center|Community Health Centers	Community Health Centers (CHCs) are private, non-profit organizations that directly or indirectly (through contracts and cooperative agreements) provide primary health services and related services to residents of a defined geographic area that is medically undeserved. Community health centers have a three-fold mission. First, CHCs aim to improve access to care for low income, underserved, vulnerable populations. They are required to be located in medically-underserved rural and urban areas, and within those communities, they serve those with limited access to more mainstream health care. Second, CHCs provide a fully comprehensive range of primary care services, including "enabling" or support services. Third, they involve the community in both the management and governance of the center. (Johns Hopkins School of Hygiene and Public Health, http://www.jhsph.edu/hao/pcpc/whatchc.htm)
C16455	Community_Health_Education	Patient_or_Public_Education	Community Health Education|Community Education	Draws on social relationships and organizations to reach large populations through media and interpersonal strategies that deliver messages and mechanisms to reduce chronic diseases.
C16456	Community_Health_Nursing	Public_Health_Nursing	Community Health Nursing
C16457	Comorbidity	Vital_Statistics	Comorbidity|comorbidity	The coexistence of two or more disease processes. (MedicineNet.com)
C16458	Comoros	Country	Comoros|174|CN|COM|KM	A group of islands in the Mozambique Channel, about two-thirds of the way between northern Madagascar and northern Mozambique. (CIA World Factbook 2002)
C16459	Complement	Immunoprotein	Complement	The complement system is a complex system of serum proteins that interact in a cascade.  Many of the early components are serine proteases that activate each other sequentially. This complement system consists of three separate activation triggers: (1) Ab binding to a cell surface, (2) formation of immune complexes, and (3) a carbohydrate component of a microbe's cell membrane.  Along with this triggers, there are also two sets of mechanisms.  Both of these mechanisms, classical pathway and alternative or properdin pathway, make MAC (Membrane Attack Complex), which can lyse and destroy the cell.
C16460	Computer_Graphics	Computer_Sciences	Computer Graphics	Computer graphics (CG) is the field of visual computing, where one utilizes computers both to generate visual images synthetically and to integrate or alter visual and spatial information sampled from the real world. (from Wikipedia)
C16461	Computer_Modeling	Computational_Technique	Computer Modeling|Mathematical Models and Simulations|Simulation|simulation	Computer modeling or computer simulation is a technique which attempts to provide an abstract model of a particular system. It utilizes a mathematical model, which attempts to predict the behavior of the system from a set of parameters and initial conditions.
C16462	Computer_System	Diagnostic_Therapeutic_and_Research_Equipment	Computer System	A computer system is a set of hardware and software which processes data in a meaningful way. (from Wikipedia)
C16463	Computer_Systems_Development	Computer_Sciences	Computer Systems Development|Systems Development
C16464	Computers	Diagnostic_Therapeutic_and_Research_Equipment	Computers	heading term for all computer related (hardware and software) terms.
C16465	Conception	Developmental_Process	Conception	Fertilization of an ovum by a spermatozoon; the act of becoming pregnant.
C16466	Confidentiality	Conceptual_Entities	Confidentiality
C16467	Congo	Country	Congo|178|CF|CG|COG|Republic of the Congo	A country in Western Africa, bordering the South Atlantic Ocean, between Angola and Gabon. (CIA World Factbook 2002)
C16468	Consent_Form	Form	Consent Form|ICF|Informed Consent Form	A document explaining all relevant study information to assist the study volunteer in understanding the expectations and requirements of participation in a clinical trial. This document is presented to and signed by the study subject. (from centerwatch.com glossary)
C16469	Cook_Islands	Country	Cook Islands|184|CK|COK|CW	A group of islands in the South Pacific Ocean, about one-half of the way from Hawaii to New Zealand. (CIA World Factbook 2002)
C16470	Costa_Rica	Country	Costa Rica|188|CR|CRI|CS	A country in Central America, bordering both the Caribbean Sea and the North Pacific Ocean, between Nicaragua and Panama. (CIA World Factbook 2002)
C16471	Costs	Medical_Economics	Costs
C16472	Cost_Benefit_Analysis	Medical_Economics	Cost/Benefit Analysis|Economics, Cost/Benefit	An analysis of the cost effectiveness of different alternatives in order to see whether the benefits outweigh the costs
C16473	Creatine_Kinase	Protein_Kinase	Creatine Kinase|CKB|Creatine Kinase-B|Creatine Kinase-B Chain|Creatine Phosphokinase|EC 2.7.3.2	Encoded by human CKB Gene (ATP:Guanido Phosphotransferase Family), 381-aa 43-kDa cytoplasmic homodimer or heterodimer Creatine Kinase is a transferase involved in energy homeostasis that primarily catalyzes reversible formation of ATP and creatine from phosphocreatine. Important in muscle contraction, the reaction stores ATP energy as phosphocreatine. Three cytoplasmic isoenzymes have been identified in human tissues: MM from skeletal muscle, MB from myocardial tissue and BB from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins. (NCI)
C16474	Croatia	Country	Croatia|191|HR|HRV	A country in Southeastern Europe, bordering the Adriatic Sea, between Bosnia and Herzegovina and Slovenia. (CIA World Factbook 2002)
C16475	Cryopreservation	Preservation_Technique	Cryopreservation	Preservation of cells, tissues, organs, or embryos by storage at low temperatures.
C16476	Crystallography	Physical_Chemical_Techniques	Crystallography	The branch of science that studies the formation and structure of crystals.
C16477	Cuba	Country	Cuba|192|CIB|CU	An island between the Caribbean Sea and the North Atlantic Ocean, 150 km south of Key West, Florida. (CIA World Factbook 2002)
C16478	Culture	Social_Concepts	Culture|Cultural	Culture is a pattern of learned beliefs, values, and behavior that are shared within a group. It includes language, styles of communication, practices, customs, and views on roles and relationships.
C16479	Protein_Kinase-A	Protein_or_Riboprotein_Complex	Protein Kinase A|PKA|cAMP-Dependent Protein Kinase	Most cellular effects of cAMP are mediated through PKA by serine or threonine phosphorylation of target proteins. Human Protein Kinase A (cAMP Ser/Thr Protein Kinase Family) is an inactive tetrameric cytoplasmic holoenzyme composed of homo- or heterodimeric regulatory subunits associated with two catalytic subunits. cAMP causes dissociation of inactive holoenzyme into a cAMP-bound dimer of regulatory subunits and two free monomeric catalytic subunits that phosphorylate many cytoplasmic and nuclear substrates. In human, regulatory PRKAR1A, PRKAR1B, PRKAR2A, and PRKAR2B subunits and catalytic PRKACA, PRKACB, and PRKACG subunits have been identified. (NCI)
C16480	Cyprus	Country	Cyprus|196|CY|CYP	An island in the Mediterranean Sea, south of Turkey. (CIA World Factbook 2002)
C16481	Cysteine_Proteinase	Protease	Cysteine Proteinase|Thiol Protease
C16482	Cystoscopy	Endoscopy	Cystoscopy|CYSTO|cystoscopy	(sist-OSS-ko-pee) Examination of the bladder and urethra using a thin, lighted instrument (called a cystoscope) inserted into the urethra. Tissue samples can be removed and examined under a microscope to determine whether disease is present.
C16483	Cytochemistry	Histology	Cytochemistry|Histology, Cytochemistry	Branch of histochemistry associated with the localization of cellular components by specific staining methods, as for example the localization of acid phosphatases by the Gomori method.
C16484	Cytochrome-P450	Cytochrome	Cytochrome P450|P450
C16485	Cytochrome-P450-2E1	Cytochrome-P450	Cytochrome P450 2E1|CYP2E1|CYPIIE1|Cytochrome P450, Family 2, Subfamily E, Polypeptide 1|Cytochrome P450, Subfamily IIE|Cytochrome P450, Subfamily IIE (Ethanol-Inducible)|Cytochrome P450, subfamily IIE (Ethanol-Inducible), Polypeptide 1|EC 1.14.14.1|Ethanol-Inducible P450|Flavoprotein-Linked Monooxygenase|Microsomal Monooxygenase|P450-2E1|P450-J|Xenobiotic Monooxygenase
C16486	Cytochrome	Oxidoreductase	Cytochrome|CYP|Cytochromes
C16487	Cytogenetics	Genetics	Cytogenetics|CYTOGEN	Cytogenetics is the study of chromosomes and the related disease states caused by numerical and structural chromosome abnormalities.
C16488	Cytokeratin-19	Cytokeratin	Cytokeratin 19|CK-19|CK19|Cytokeratin-19	A protein often found as a cell surface marker on tumor cells.
C16489	Cytokinesis	Cell_Division_Process	Cytokinesis	Process in which the cytoplasm of a cell is divided after nuclear division (mitosis) is complete.  (On-line Medical Dictionary)
C16490	Cytological_Techniques	Research_Techniques	Cytological Techniques	Techniques for manipulation of cells and analysis of cell properties and subcellular features.
C16491	Cytology	Histology	Cytology|Histology, Cytology	The light microscopic study of normal and abnormal cells in fine needle aspirates (FNAs), body cavity fluids, and smears. -- 2004
C16492	Cytoskeletal_Protein	Structural_Protein	Cytoskeletal Protein	Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.
C16493	Data_Sources	Source	Data Source|Data Sources	The person or authoritative body who provided the information.
C16495	Demographics	Properties_or_Attributes	Demographics|Demographic Factor|Demographic Factors|Demography|Population Studies / Demography	The statistical characterization of human populations or segments of human populations (e.g., characterization by age, sex, race, or income).
C16496	Denmark	Country	Denmark|208|DA|DK|DNK	A country in Northern Europe, bordering the Baltic Sea and the North Sea, on a peninsula north of Germany (Jutland); also includes two major islands (Sjaelland and Fyn). (CIA World Factbook 2002)
C16497	Dentistry	Health_Sciences	Dentistry
C16498	Deoxycytidine_Kinase	Kinase	Deoxycytidine Kinase|2'-Deoxycytidine Kinase|ARA-C Kinase|DCK|EC 2.7.1.74	Deoxycytidine Kinase, encoded by the DCK gene, is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. (from LocusLink)
C16499	Deoxyribonuclease	Esterase	Deoxyribonuclease	Enzymes that catalyze the hydrolytic cleavage of phosphodiester bond linkages in the DNA backbone. Deoxyribonucleases belong to a larger family of nucleases, which cleave DNA bases at various positions in the DNA backbone.
C16500	Dermatology	Medical_Specialty	Dermatology
C16501	Developmental_Biology	Biology	Developmental Biology	The study of how a multicellular organism develops from its early immature forms (e.g., zygote, larva, embryo) into an adult. (from On-line Medical Dictionary)
C16502	Diagnostic_Imaging	Medical_Imaging	Diagnostic Imaging	Any method that uses a visual display of structural or functional patterns of organs or tissues for diagnostic evaluation..
C16503	Digestion	Gastrointestinal_Process	Digestion	The process or act of converting food into chemical substances that can be absorbed and assimilated.
C16504	Animal_Model	in_vivo_Model	Animal Model|Animal Models and Related Studies|Disease Models, Animal|animal model	An animal with a disease either the same as or like a disease in humans. Animal models are used to study the development and progression of diseases and to test new treatments before they are given to humans. Animals with transplanted human cancers or other tissues are called xenograft models.
C16505	Susceptibility	Health_Status	Susceptibility|Predisposition	The constitutional or inborn state disposing to a disease, group of diseases, or metabolic or structural anomaly.
C16506	Djibouti	Country	Djibouti|262|DJ|DJI	A country in Eastern Africa, bordering the Gulf of Aden and the Red Sea, between Eritrea and Somalia. (CIA World Factbook 2002)
C16507	DNA_Damage	Pathologic_Mutagenesis	DNA Damage	Drug-, radiation-induced, or spontaneous injuries to DNA that introduce deviations from its normal double-helical conformation. These changes include structural distortions that interfere with replication and transcription, as well as point mutations that disrupt base pairs and exert damaging effects on future generations through changes in DNA sequence. If the damage is minor, it can often be repaired (DNA repair); extensive damage can induce apoptosis.
C16508	DNA_Modification_Methylase	Methyltransferase	DNA Modification Methylases|DNA Methyltransferases|DNA-Methyltransferases|Dnmt|EC 2.1.1.113|Site-Specific DNA-methyltransferase	An enzyme that binds to specific DNA sequences and protects the nucleotides therein. The nucleotide sequence contains a cognate recognition sequence that is protected from digestion by exonucleases. The enzyme protects the sequence by methylation on an adenine or cytosine residue. If the DNA is left unprotected, it will be proteolytically cleaved by host endonucleases.
C16509	Terminal_Deoxyribonucleotidyl_Transferase	DNA_Polymerase	Terminal Deoxyribonucleotidyl Transferase|DNA Nucleotidylexotransferase|DNTT|Deoxynucleotidyl Terminal Transferase|EC 2.7.7.31|TdT|Terminal Deoxynucleotidyltransferase	Terminal deoxynucleotidyltransferase is a unique DNA polymerase that without template direction catalyzes the addition of deoxyribonucleotides onto the 3-prime-hydroxyl end of DNA primers. TDT catalyzes the insertion of nucleotides (N regions) at the V(H)-D and D-J(H) junctions of immunoglobulin genes. The enzyme is present in immature thymocytes, some bone marrow cells, transformed pre-B and pre-T cell lines, and leukemia cells.
C16510	DNA_Polymerase_Alpha	Bacterial_Protein	DNA Polymerase Alpha|Alpha DNA polymerase	An enzyme that plays major roles in DNA metabolism. The protein, which exhibits bidirectional nuclease activity is required for both DNA synthesis and repair. DNA polymerase alpha is most active in dividing cells, and is primarily involved with lagging strand synthesis.
C16511	DNA_Polymerase_Delta	DNA-Directed_DNA_Polymerase	DNA Polymerase Delta|Delta DNA Polymerase	An enzyme that has dual functionality in DNA synthesis. The protein has the ability to facilitate DNA synthesis by polymerase action and an exonucleolytic activity that degrades single stranded DNA in the 3' to 5' direction. This protein is essential for leading strand synthesis.
C16512	DNA-Directed_DNA_Polymerase	DNA_Polymerase	DNA-directed DNA Polymerase|DNA-Dependent DNA Polymerase|EC 2.7.7.7	Catalyses DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time. Cannot initiate a chain de novo. Requires a primer, which may be DNA or RNA. (IUBMB Enzyme Nomenclature)
C16513	DNA_Repair	DNA_Maintenance	DNA Repair|DNA Damage Repair|Unscheduled DNA Synthesis	Enzymatic restoration of DNA structure after chemical, radiation, or spontaneous damage.
C16514	DNA_Replication	Replication-Associated_Process	DNA Replication|Replication	The process by which the two strands of a DNA double helix separate, allowing each strand to act as a template for the synthesis of a complementary strand by specific base pairing. Includes autonomous but not virus replication.
C16515	Restriction_Endonuclease	Deoxyribonuclease	Restriction Endonuclease	Enzymes that exhibit endonuclease activity at a specific short nucleotide sequence to cleave strands of DNA. These enzymes are commonly used as tools in recombinant DNA technology.
C16516	Topoisomerase-I	Topoisomerase	Topoisomerase I|DNA Topoisomerase I|TOP1|Topo I|Topoisomerase (DNA) I|Topoisomerase, DNA, I|Type I DNA Topoisomerase	Encoded by human TOP1 Gene (TOPI Family), 765-aa 90.7-kD monomeric DNA Topoisomerase I catalyzes transient ATP-independent breaking/rejoining of DNA and controls DNA topology during transcription. DNA topoisomerases I and II relax negative and positive supercoils; TOP1 breaks single DNA strands, TOP2 breaks duplex DNA. Specifically inhibited by the antitumor plant alkaloid CPT, when TOP1 breaks the DNA backbone bond it forms a protein-DNA link (a tyrosyl oxygen joins to a DNA strand end phosphorus). (from LocusLink, Swiss-Prot, OMIM, and NCI)
C16517	DNA_Helicase	Helicase	DNA Helicase|Helicase	A class of enzymes that utilizes the energy of ATP hydrolysis to unwind (unzipped) dsDNA. The enzyme participate in various of biological process including DNA replication, transcription and recombination.
C16518	DNA_Binding_Protein	Ligand_Binding_Protein	DNA Binding Protein	Proteins that non-covalently interact with deoxyribonucleic acid as a result of intermolecular physical forces and spatial complementarity. Many genetic regulatory DNA binding proteins bind to double- or single-stranded DNA in a sequence-specific manner and share common structural motifs such as the zinc-finger, helix-turn-helix, and leucine zipper.
C16519	Dominica	Country	Dominica|212|DM|DMA|DO	An island between the Caribbean Sea and the North Atlantic Ocean, about one-half of the way from Puerto Rico to Trinidad and Tobago. (CIA World Factbook 2002)
C16520	Dominican_Republic	Country	Dominican Republic|214|DO|DOM|DR	A country comprising the eastern two-thirds of the island of Hispaniola, between the Caribbean Sea and the North Atlantic Ocean, east of Haiti. (CIA World Factbook 2002)
C16521	Transcriptional_Repression	Transcriptional_Regulation	Transcriptional Repression|Gene Down-Regulation|Gene Repression|Transcription Repression	Decreased expression of some gene product.
C16522	Drug_Abuse	Substance_Abuse	Drug Abuse|Recreational Drug Use	The use of a drug for a reason other than which it was intended or in a manner or in quantities other than directed.
C16523	Drug_Resistance	Resistance	Drug Resistance	Diminished or failed response of an organism, disease, or tissue to the intended effectiveness of a chemical or drug. Mechanisms, functions, activities, or processes exhibited by pathogens to withstand previously toxic drugs.
C16525	Echocardiography	Procedure	Echocardiography|echocardiography	A procedure that uses ultrasonic waves directed over the chest wall to obtain a graphic record of the heart's position, motion of the walls, or internal parts such as the valves.
C16526	Ecology	Biology	Ecology	The branch of biology concerned with the relations between organisms and their environment.
C16527	Medical_Economics	Social_Sciences	Medical Economics	Economic aspects of the field of medicine, the medical profession, and health care. It includes the economic and financial impact of disease in general on the patient, the physician, society, or government. (On-line Medical Dictionary)
C16528	Ecuador	Country	Ecuador|218|EC|ECI	A country in Western South America, bordering the Pacific Ocean at the Equator, between Colombia and Peru. (CIA World Factbook 2002)
C16529	Education	Training_and_Education	Education	The activities of educating or instructing or teaching; activities that impart knowledge or skill.
C16530	Egypt	Country	Egypt|818|EG|EGY	A country in Northern Africa, bordering the Mediterranean Sea, between Libya and the Gaza Strip. (CIA World Factbook 2002)
C16531	Ejaculation	Reproductive_System_Process	Ejaculation|EJC|ejaculation	Ejaculation is the release of semen through the penis during orgasm. (NCI)
C16532	El_Salvador	Country	El Salvador|222|ES|SLV|SV	A country in Central America, bordering the North Pacific Ocean, between Guatemala and Honduras. (CIA World Factbook 2002)
C16533	Electromagnetic_Fields	Electromagnetic_Radiation	Electromagnetic Field|EMF|Radiation, Electromagnetic Field	Field of force associated with a moving electric charge and consisting of electric and magnetic fields that are generated at right angles to each other.
C16534	Electron_Spin_Resonance_Spectroscopy	Spectroscopy	Electron Spin Resonance Spectroscopy|ESR|ESR Spectroscopy|Electron Paramagnetic Resonance|Electron Spin Resonance|Spectroscopy, ESR|Spectroscopy, Electron Spin Resonance	A spectrometric method, based on measurement of electron spins and magnetic moments, for detecting and estimating free radicals in reactions and in biological systems.
C16535	Beta_Radiation	Charged_Particles_Radiation	Beta Radiation|Beta-Radiation|Radiation, Charged Particles-Electrons	Radiation of beta particles during radioactive decay.
C16536	Electrophoresis	Biomolecule_Separations_Technology	Electrophoresis|Fractionation, Electrophoretic	The motion of charged particles in a colloid under the influence of an electric field; particles with a positive charge go to the cathode and negative to the anode.
C16537	Agarose_Gel_Electrophoresis	Gel_Electrophoresis	Agarose Gel Electrophoresis|Fractionation, Agarose Gel	A type of gel electrophoresis used in molecular biology to separate DNA strands by size using electrophoretic filtration with agarose as the support medium. Also used to separate proteins, lipoproteins, nucleic acids, and other substances.
C16538	_2-D_Gel_Electrophoresis	Gel_Electrophoresis	2-D Gel Electrophoresis|2 Dimensional Gel Electrophoresis|Two Dimensional Gel Electrophoresis	A technique in which proteins are first separated across a gel, usually polyacrylamide, according to their isoelectric point, and then separated in a perpendicular direction on the basis of their molecular weight.
C16539	Polyacrylamide_Gel_Electrophoresis	Gel_Electrophoresis	Polyacrylamide Gel Electrophoresis|Fractionation, Polyacrylamide Gel|PAGE|electrophoresis, polyacrylamide gel	Analytical and separative technique in which molecules, particularly proteins or nucleic acids, are separated by their different electrophoretic mobilities in a hydrated gel. The gel suppresses convective mixing of the fluid phase through which the electrophoresis takes place and contributes molecular sieving. For proteins, commonly carried out in the presence of the anionic detergent sodium dodecylsulphate (SDS). SDS denatures proteins so that noncovalently associating sub unit polypeptides migrate independently and by binding to the proteins confers a net negative charge roughly proportional to the chain weight.
C16540	Electrophysiology	Neurophysiology	Electrophysiology|Neurophysiology / Electrophysiology	That branch of physiology that is concerned with the electric phenomena associated with living bodies and involved in their functional activity. (On-line Medical Dictionary)
C16541	Embryo_Transfer	Reproductive_Techniques	Embryo Transfer	Refers to a step in the process of in vitro fertilization (IVF) whereby one or several embryos are removed from an embryo culture and placed into the uterus of the female with the intent to establish a pregnancy. (NCI2005)
C16542	Embryology	Developmental_Biology	Embryology	The branch of biology that studies the formation and early development of living organisms.
C16543	Endocrinology	Internal_Medicine	Endocrinology|Endocrinology and Metabolism|Metabolism and Endocrinology	The science and medical specialty concerned with the metabolism, physiology, or hormonal secretions and their physiologic and pathologic relations.
C16544	Endocytosis	Transmembrane_Transport	Endocytosis	Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. Endosomes play a central role in endocytosis.
C16545	Endoscope	Imaging_Device	Endoscope|endoscope	(EN-dah-skope) A thin, lighted tube used to look at tissues inside the body.
C16546	Endoscopy	Procedure	Endoscopy|endoscopy	(en-DAHS-ko-pee) The use of a thin, lighted tube (called an endoscope) to examine the inside of the body.
C16547	Energy_Metabolism	Intermediary_Metabolism	Energy Metabolism	Any subcellular or molecular event, process, or condition concerned with storing and generating metabolic energy. (NCI)
C16548	Engineering	Technology	Engineering
C16549	Engineering_Psychology	Psychology	Engineering Psychology	Branch of applied psychology that emphasizes the study of machine design, the relationship between humans and machines, and the effects of machines on human behavior. Use a more specific term if possible. (PSY94)
C16550	Entomology	Invertebrate_Biology	Entomology	Entomology; the branch of zoology that studies insects.
C16551	Environment	Conceptual_Entities	Environment	The totality of surrounding conditions.
C16552	Environmental_Exposure	Environmental_and_Occupational_Exposure	Environmental Exposure	Exposure to potentially harmful chemical, physical or biological agents via the environment.
C16553	ELISA	Enzyme_Immunoassay	ELISA|Enzyme-linked Immunosorbent Assay	A highly sensitive technique for detecting and measuring antigens or antibodies in a solution; the solution is run over a surface to which immobilized antibodies specific to the substance have been attached, and if the substance is present, it will bind to the antibody layer, and its presence is verified and visualized with an application of antibodies that have been tagged in some way. (BioTech Life Science Dictionary)
C16554	Enzyme	Protein_Organized_by_Function	Enzyme|Enzymes|enzyme	A protein that speeds up chemical reactions in the body.
C16555	Epidemiological_Methods	Research_Techniques	Epidemiological Methods|Epidemiological Techniques|Epidemiology, Methods	Epidemiological methods involve sophisticated statistics and higher mathematics.  These methods allow epidemiologists to address issues like non-experimental studies of mechanistic questions in disease etiology, including studies of the impact of the social position of individuals in different social contexts.
C16556	Epidemiology	Medicine|Population_Sciences	Epidemiology|epidemiology	The study of the causes, incidence and distribution of disease in the population and its application for prevention or control.
C16557	Equatorial_Guinea	Country	Equatorial Guinea|226|EK|GNQ|GQ	A country in Western Africa, bordering the Bight of Biafra, between Cameroon and Gabon; composed of a mainland portion and five inhabited islands. (CIA World Factbook 2002)
C16558	Eritrea	Country	Eritrea|232|ER|ERI	A country in Eastern Africa, bordering the Red Sea, between Djibouti and Sudan. (CIA World Factbook 2002)
C16559	Erythropoiesis	Myelopoiesis	Erythropoiesis	The production of erythrocytes. In the human, in early embryonic life they are produced in the yolk sac; in the middle trimester, by the liver; in the third trimester and after birth, by the bone marrow exclusively. The maintenance in a normal individual of a remarkably constant erythrocyte count and erythrocyte mass in the peripheral blood implies the existence of an erythropoietic stimulus that under physiological conditions so regulates the rate of production of new erythrocytes as to balance the rate of normal destruction. (Guyton, Textbook of Medical Physiology, 8th ed, p356 & Miale, Laboratory Medicine Hematology, 6th ed, p17) Erythropoiesis is the formation and development of mature red blood cells (erythrocytes).
C16560	Esophagoscopy	Endoscopy	Esophagoscopy|esophagoscopy	(eh-sof-a-GAHS-ko-pee) Examination of the esophagus using a thin, lighted tube.
C16561	Esterase	Hydrolase	Esterase|Ester Hydrolase	Encoded by Esterase Genes, Esterases catalyze hydrolysis of ester bonds to produce alcohol and acid reaction products. (NCI)
C16562	Estonia	Country	Estonia|233|EE|EN|EST	A country in Eastern Europe, bordering the Baltic Sea and Gulf of Finland, between Latvia and Russia. (CIA World Factbook 2002)
C16563	Ethiopia	Country	Ethiopia|231|ET|ETH	A country in Eastern Africa, west of Somalia. (CIA World Factbook 2002)
C16564	Ethnic_Group	Population_Group	Ethnic Group|ETHN|Ethnic Origin|Ethnic Origins|Ethnicity	A social group characterized by a distinctive social and cultural tradition maintained from generation to generation, a common history and origin and a sense of identification with the group; members of the group have distinctive features in their way of life, shared experiences and often a common genetic heritage; these features may be reflected in their experience of health and disease.
C16565	Evolution	Population_Process	Evolution	The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
C16566	Excision_Repair	DNA_Repair	Excision Repair	Excision Repair mechanisms remove and replace damaged nucleotides from DNA molecules with new nucleotide subunits, e.g., Base Excision Repair, Nucleotide Excision Repair, or SOS Function.
C16567	Exercise	Physical_Activity	Exercise	Activity that requires physical or mental exertion, especially when performed to develop or maintain fitness.
C16568	Exocytosis	Cellular_Secretion	Exocytosis	Cellular release of secretory products within membrane-limited vesicles or granules.
C16569	DNA_Exonuclease	Deoxyribonuclease	DNA Exonuclease|exodeoxyribonuclease	Enzymes that sequentially catalyze the hydrolysis of single nucleotides from the end of a DNA chain. These enzymes play an important role during DNA repair.
C16570	Coagulation_Factor-VII	Coagulation_Factor	Coagulation Factor VII|EC 3.4.21.21|Eptacog Alfa|F7|Factor VII|Serum Prothrombin Conversion Accelerator	A clotting factor found in the serum.  It combines with tissue factor (factor III) to activate factor X in the clotting pathway.
C16571	Coagulation_Factor-VIII	Coagulation_Factor	Coagulation Factor VIII|Antihaemophilic Factor|Coagulation Factor VIIIc|F8|Factor VIII|Factor VIII F8B|Procoagulant Component	Human coagulation factor-VIII (2351 aa, 267 kDa precursor) is encoded by human factor eight (F8) gene. The protein is an extracellular anti-hemophilic factor that is part of the von Willebrand factor complex. The protein plays a role in the blood coagulation pathway.
C16572	von_Willebrand_Factor	Coagulation_Factor	von Willebrand Factor|Factor VIII Related Antigen|vWF|vWFAg|von Willebrand Factor Antigen	Human von Willebrand factor, a 270 kD multimeric plasma glycoprotein, has functional binding domains to platelet glycoprotein Ib, glycoprotein Iib/IIIa, collagen and heparin. It mediates platelet adhesion to injured vessel walls and serves as a carrier and stabiliser for coagulation factor VIII.  It is expressed in endothelial cells, platelets, megakaryocytes and a number of tumors. (NCI)
C16573	Faroe_Islands	Country	Faroe Islands|234|FO|FRO|Faeroe Islands	An island group between the Norwegian Sea and the North Atlantic Ocean, about one-half of the way from Iceland to Norway. (CIA World Factbook 2002)
C16574	Fatty_Acid_Synthase	Acyltransferase	Fatty Acid Synthase|EC 2.3.1.85|FAS|FASN	Fatty acid synthase (FAS) is a key metabolic enzyme catalyzing the synthesis of long-chain saturated fatty acids. It plays a central role in the production of surfactant in fetal lungs, in the supply of fatty components of milk, and in the conversion and storage of energy in liver and adipose tissue. Remarkably high levels of FAS expression are found in the majority of human epithelial cancers.  Experimental manipulation suggests a link between FAS overexpression and dysregulation of membrane composition and functioning in tumor cells. (from Biochem Biophys Res Commun 2003;302:898-903)
C16575	Ingestive_Behavior	Behavior	Ingestive Behavior	Eating habits and their role in human disease
C16576	Female	General_Modifier	Female|F	A person who belongs to the sex that normally produces ova. The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both.
C16577	Ferritin	Trace_Metal_Storage_Protein	Ferritin	An iron protein complex, containing up to 23% iron, formed by the union of ferric iron with apoferritin; it is found in the intestinal mucosa, spleen, bone marrow, reticulocytes, and liver, and regulates iron storage and transport from the intestinal lumen to plasma.
C16578	Fertility	Personal_Attribute	Fertility|fertility	(fer-TIL-i-tee) The ability to produce children.
C16579	Fertilization	Conception	Fertilization|Fertility/Fertilization	The process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronuclei.
C16580	in_vitro_Fertilization	Reproductive_Techniques	in vitro Fertilization|Artificial Fertilization|IVF	It is a process whereby ova are fertilized by sperms from designated partner in Petri dish, and the zygote thus produced was then introduced into the uterus and allowed to develop to term.  A treatment for couples who have infertility conditions
C16581	Fibronectin	Extracellular_Matrix_Protein	Fibronectin|CIG|Cold-Insoluble Globulin|FN|FN1|FNZ|Fibronectin 1|LETS|LETS Protein|Large External Transformation-Sensitive Protein	Encoded as alternative isoforms by human FN1 Gene, 2386-aa 262.6-kD Fibronectin precursor is a sulfated disulfide bound glycoprotein with multiple type I, II, and III fibronectin domains. MSF FN70 is an isoform. Plasma (hepatocytes) and cellular (fibroblasts and epithelia) FN differ in activity. Cell surface cellular FN (di/multimeric) is deposited in the ECM. FN is involved in embryogenesis, cell adhesion, migration, and motility, opsonization, wound healing, coagulation, host defense, cell shape, and metastasis. It stimulates endocytosis and may promote clearance of C1q-coated immune complexes. FN binds cell surface integrin, C1q, collagen, fibrin, hyaluronic acid, heparin, FBLN1, and actin. Most cells depend on FN to bind collagen. Talin-1 may link FN/Integrin with the actin cytoskeleton. FN may promote contact inhibition. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C16582	Fiji	Country	Fiji|242|FJ|FJI	An island group in the South Pacific Ocean, about two-thirds of the way from Hawaii to New Zealand. (CIA World Factbook 2002)
C16583	Filtration	Biomolecule_Separations_Technology	Filtration|Fractionation, Filtration	The process of passing a liquid or gas through a filter.
C16584	Finland	Country	Finland|246|FI|FIN	A country in Northern Europe, bordering the Baltic Sea, Gulf of Bothnia, and Gulf of Finland, between Sweden and Russia. (CIA World Factbook 2002)
C16585	Flow_Cytometry	Cell_Sorting	Flow Cytometry|FCM	Flow cytometry is a technique for counting, examining and sorting microscopic particles suspended in a stream of fluid. (from Wikipedia)
C16586	Fluorescence	Physical_Phenomena_or_Properties	Fluorescence	Fluorescence is a luminescence (i.e., optical phenomenon) in cold bodies, in which a molecule absorbs a high-energy photon, and re-emits it as a lower-energy (longer-wavelength) photon. The energy difference between the absorbed and emitted photons ends up as molecular vibrations (heat).
C16587	Fluorophotometry	Research_Techniques|Test_Generic	Fluorophotometry	Measurement of light given off by fluorescein in order to assess the integrity of various ocular barriers. The method is used to investigate the blood-aqueous barrier, blood-retinal barrier, aqueous flow measurements, corneal endothelial permeability, and tear flow dynamics (From MSH2001).
C16588	Fluoroscopy	Diagnostic_Radiology	Fluoroscopy|fluoroscopy	(floor-AHS-ko-pee) An x-ray procedure that makes it possible to see internal organs in motion.
C16589	Food_Microbiology	Microbiology	Food Microbiology	The field of study concerned with the study of food-borne microorganisms.
C16590	Food_Industry	Technology	Food Industry	The industry concerned with processing, preparing, preserving, distributing, and serving of foods and beverages.
C16591	Forensic_Medicine	Medical_Specialty	Forensic Medicine|Forensics	Forensic medicine.  medicine in its relations to law. (from On-line Medical Dictionary)
C16592	France	Country	France|250|FR|FRA	A country in Western Europe, bordering the Bay of Biscay and English Channel, between Belgium and Spain, southeast of the UK; bordering the Mediterranean Sea, between Italy and Spain. (CIA World Factbook 2002)
C16593	French_Guiana	Country	French Guiana|254|FG|GF|GUF	A country in Northern South America, bordering the North Atlantic Ocean, between Brazil and Suriname. (CIA World Factbook 2002)
C16594	French_Polynesia	Country	French Polynesia|258|FP|PF|PYF	An archipelago in the South Pacific Ocean, about one-half of the way from South America to Australia. (CIA World Factbook 2002)
C16595	Fucosyltransferase	Glycosyltransferase	Fucosyltransferase|Alpha-Fucosyltransferases	Belongs to the family of EC 2.4.1 glycosyltransferases. The enzyme catalyzes the transfer o f fucose molecule from dinucleotide compound to another carbohydrate compound.
C16596	Gabon	Country	Gabon|266|GA|GAB|GB	A country in Western Africa, bordering the Atlantic Ocean at the Equator, between Republic of the Congo and Equatorial Guinea. (CIA World Factbook 2002)
C16597	Galactosyltransferase	Glycosyltransferase	Galactosyltransferase	Enzymes that catalyze the transfer of a galactosyl group from a donor to an acceptor compound. The acceptor molecule is frequently a carbohydrate moiety.
C16598	Gambia	Country	Gambia|270|GA|GM|GMB	A country in Western Africa, bordering the North Atlantic Ocean and Senegal. (CIA World Factbook 2002)
C16599	Gametogenesis	Cell_Differentiation	Gametogenesis	Gametogenesis is the phase of sexual reproduction in which certain cells of a female or male individual (parent) are transformed into specialized reproductive cells (gametes) that will initiate development of a progeny individual (offspring) upon fertilization.
C16600	Gamma_Camera	Imaging_Device	Gamma Camera	An instrument used in medicine to produce images of internal organs after the injection of a radioactive drug into the body, where the drug releases gamma rays. It is used especially in medical diagnostic scanning. (Encarta Dictionary and Merriam-Webster Online Dictionary)
C16601	Gamma_Globulin	Serum_Globulin	Gamma Globulin	A type of globulin in plasma that in electrically charged solutions exhibits slowest colloidal mobility after that of the alpha and beta globulins. All immunoglobulins belong to this group of serum protein.
C16602	Gamma-Glutamylcysteine_Synthetase	Protein_or_Riboprotein_Complex	Gamma-Glutamylcysteine Synthetase|EC 6.3.2.2|Gamma-Glutamylcysteinyl Synthetase|Glutamate-Cysteine Ligase	Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. The gene encoding the catalytic subunit encodes a protein of 367 amino acids with a calculated molecular weight of 72.773 kDa and maps to chromosome 6. The regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Deficiency of gamma-glutamylcysteine synthetase in human is associated with enzymopathic hemolytic anemia. (LocusLink)
C16603	Gastroenterology	Internal_Medicine	Gastroenterology
C16604	Gastroscopy	Endoscopy	Gastroscopy|gastroscopy	(gas-TRAHS-ko-pee) An examination of the inside of the stomach using a thin, lighted tube (called a gastroscope) passed through the mouth and esophagus.
C16605	Gene_Amplification	DNA_Sequence_Rearrangement	Gene Amplification	This technique refers to selectively replicate DNA sequence of interest to multiple extra copies that meet the need of research or health care activity. Polymerase chain reaction (PCR), can be considered a type of man-made gene amplification process.
C16606	Gene_Deletion	Gene_Mutation	Gene Deletion|gene deletion	A partial or total loss of a gene through loss of a segment(s) of DNA or RNA.  This loss catalyzes the rearrangement of genetic material, bringing sequences that are normally separated into close proximity.
C16607	Gene_Duplication	Gene_Amplification	Gene Duplication	A chromosomal structural change resulting in the doubling of a section of the genome of prokaryotes and eukaryotes. The size of the duplicated segment may vary considerably. Duplications may be interchromosomal, with the duplicate segment incorporated into another chromosome, or intrachromosomal, with the duplicate region present in the same chromosome. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed) The production of a tandem repeat of a DNA sequence by unequal crossing over or by an accident of replication.  Inclusion of two copies of the same genetic material in a genome; an important step in diversification of genomes, as in the evolution of the (non-allelic) hemoglobin chains from a common ancestor.
C16608	Gene_Expression	Gene_Expression_Process	Gene Expression|EXP|Expression	Typically involves transcription of genetically encoded information into an intermediary message (messenger RNA) and subsequent translation into a functional protein.
C16609	Regulation_of_Gene_Expression	Retired_Concepts	Regulation of Gene Expression|Gene Expression Regulation|Gene Regulation
C16610	ENV_Protein	Viral_Protein	ENV Protein|Envelope Protein	Proteins that comprise the membrane or envelope that encapsulates a virus. These proteins often require proteolytic cleavage for functional activity.
C16611	Gene_Rearrangement	DNA_Sequence_Rearrangement	Gene Rearrangement	Covalent DNA changes in cells during normal differentiation resulting in new sequences, expression, or gene products; this is a mechanism of binding site diversification for antibodies, certain receptors, and possibly other proteins.  The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.  This includes the ordered rearrangement of variable gene regions; especially, the rearrangement of antibody genes during the differentiation of B-lymphocytes and the rearrangement of T-cell antigen receptor genes.
C16612	Gene	root_node	Gene|Genes|gene	A functional unit of heredity which occupies a specific position (locus) on a particular chromosome, is capable of reproducing itself exactly at each cell division, and directs the formation of a protein or other product. The gene as a functional unit consists of a discrete segment of a giant DNA molecule containing the purine (adenine and guanine) and pyrimidine (cytosine and thymine) bases in the ordered and correct sequence that encodes a specific functional product (i.e., a protein or RNA molecule).
C16613	ENV	Viral_Envelope_Gene	ENV|ENV Gene	DNA sequences that form the coding region for the viral envelope (env) proteins in retroviruses.
C16614	GAG_Gene	Viral_Gene	GAG Gene|GAG
C16615	Homeobox_Gene	Transcription_Factor_Gene	Homeobox Gene|Homeobox Family Gene|Homeodoamin Gene	Highly conserved DNA sequences which have been identified in specific gene transcripts ranging from those of Drosophila melanogaster to mouse and human. Homeobox genes function, in part, to generate DNA-binding proteins with an evolutionary conserved approximately 60-residue sequence (HOMEODOMAIN PROTEINS).
C16616	MHC_Class-II_Gene	Major_Histocompatibility_Complex_Gene	MHC Class II Gene|Class II MHC|MHC Class II	Genetic loci in the vertebrate major histocompatibility complex that encode polymorphic products which control the immune response to specific antigens. The genes are found in the HLA-D region in humans and in the I region in mice. Present peptides to CD4+ T cells.
C16617	MHC_Class-I_Gene	Major_Histocompatibility_Complex_Gene	MHC Class I Gene|Class I MHC|MHC Class I	Genetic loci in the vertebrate major histocompatibility complex which encode polymorphic characteristics not related to immune responsiveness or complement activity, e.g., B loci (chicken), DLA (dog), GPLA (guinea pig), H-2 (mouse), RT-1 (rat), HLA-A, -B, and -C class I genes of man. Present peptides to CD8+ T cells.
C16618	POL_Gene	Viral_Gene	POL Gene|POL
C16619	TAT_Gene	Viral_Gene	TAT Gene|TAT	DNA sequences that form the coding region for the protein responsible for trans-activation of transcription (tat) in human immunodeficiency virus (HIV).
C16620	Viral_Gene	Non-Human_Gene	Viral Gene	Genes of viral origin.
C16621	Genetic_Engineering	Biotechnology	Genetic Engineering|Biotechnology, Genetic Engineering|Gene Splicing|Genetically Engineered|Molecular Biology, Genetic Engineering|Recombinant DNA Technology	The technology of preparing recombinant DNA in vitro by cutting up DNA molecules and splicing together fragments from more than one organism. (Wikipedia)
C16622	Genetic_Marker	Biomarker	Genetic Marker|genetic markers	Alterations in DNA that may indicate an increased risk of developing a specific disease or disorder.
C16623	Genetic_Techniques	Research_Techniques	Genetic Techniques	Chromosomal, biochemical, intracellular, and other methods used in the study of genetics, including RNA and DNA chemistry.(NCI2005)
C16624	Genetics	Biology	Genetics	The branch of biology that deals with heredity, especially the mechanisms of hereditary transmission and the variation of inherited characteristics among similar or related organisms
C16625	Behavioral_Genetics	Genetics	Behavioral Genetics|Genetic Determinants of Behavior	The study of the genetic factors of behavioral phenotypes such as eating or mating activity, substance abuse, social attitudes, violence, and mental abilities. (from online American Heritage Dictionary of the English Language)
C16626	Biochemical_Genetics	Genetics	Biochemical Genetics
C16627	Medical_Genetics	Human_Genetics	Medical Genetics|Genetics, Medical
C16628	Population_Genetics	Genetics	Population Genetics|Genetics, Population
C16629	Genome	Cancer_Science	Genome|Genomic|genome	The complete genetic material of an organism.
C16630	Human_Genome	Genome	Human Genome	The total gene complement, about 3 billion base pairs of DNA, contained in the human chromosomes.
C16631	Genotype	Miscellaneous_Molecular_Biology_Terms	Genotype	The genetic constitution of an organism or cell, as distinct from its expressed features or phenotype.
C16632	Geographic_Area	Conceptual_Entities	Geographic Area|Geographic Location|Geographic Region	Any entity that occupies a location.  It is usually used to refer to all of the continents and every country and area situated within but also includes generic locations of health care delivery. They are significant in epidemiologic studies and historical articles and for locating administrative units in education and the delivery of health care.
C16633	Geography	Physical_Sciences	Geography	The science that deals with the world and its inhabitants; a description of the earth, or a portion of the earth, including its structure, features, products, political divisions, and the people by whom it is inhabited. (from On-line Medical Dictionary)
C16634	Georgia	Country	Georgia|268|GE|GEO|GG|Georgia (Republic)	A country in Southwestern Asia, bordering the Black Sea, between Turkey and Russia. (CIA World Factbook 2002)
C16635	Geriatrics	Medical_Specialty	Geriatrics|Gerontology|Gerontology / Geriatrics	The branch of medical science that deals with diseases and problems specific to elderly people.
C16636	Germany	Country	Germany|276|DE|DEU|GM	A country in Central Europe, bordering the Baltic Sea and the North Sea, between the Netherlands and Poland, south of Denmark. (CIA World Factbook 2002)
C16637	Gold_Coast	Retired_Concepts	Gold Coast
C16638	Gibraltar	Country	Gibraltar|292|GI|GIB	A dependency in Southwestern Europe, bordering the Strait of Gibraltar, on the southern coast of Spain. (CIA World Factbook 2002)
C16639	Kiribati	Country	Kiribati|296|KI|KIR|KR	A group of 33 coral atolls in the Pacific Ocean, straddling the equator; the capital Tarawa is about one-half of the way from Hawaii to Australia. (CIA World Factbook 2002)
C16640	Glucose-6-Phosphate_Dehydrogenase	Oxidoreductase	Glucose-6-Phosphate Dehydrogenase|EC 1.1.1.49|G6PD	Encoded as 2 alternative isoforms by human housekeeping G6PD Gene (G6PD Family), 514-/560-aa 59-kDa homodimeric or homotetrameric cytosolic Glucose-6-Phosphate Dehydrogenase mainly produces NADPH, an electron donor to oxidizing agents and in biosynthetic reactions. G6PD deficiency may cause jaundice, hemolysis, or non-spherocytic hemolytic anemia. (NCI)
C16641	Glutathione_S-Transferase	Alkyltransferase_and_Aryltransferase	Glutathione S-Transferase|EC 2.5.1.18|GST|Glutathione S-Alkyltransferase|Glutathione S-Aralkyltransferase|Glutathione S-Aryltransferase|S-(Hydroxyalkyl)Glutathione Lyase	A class of enzymes that catalyze the reaction of glutathione with an acceptor molecule (an arene oxide) to form an S-substituted glutathione; a key step in detoxification of many substances; start of the mercapturic acid pathway.
C16642	Glycoprotein	Protein_Organized_by_Structure	Glycoprotein|glycoprotein	A conjugated protein having a carbohydrate component.
C16643	Protein_Glycosylation	Post-Translational_Modification	Protein Glycosylation|Glycosylation	The covalent chemical or post-translational biochemical addition of carbohydrate or glycosyl groups to peptides or proteins by glycosyl transferases.
C16644	Grants	Funding_Mechanisms	Grants
C16645	Greece	Country	Greece|300|GR|GRC	A country in Southern Europe, bordering the Aegean Sea, Ionian Sea, and the Mediterranean Sea, between Albania and Turkey. (CIA World Factbook 2002)
C16646	Greenland	Country	Greenland|304|GL|GRL	An island between the Arctic Ocean and the North Atlantic Ocean, northeast of Canada. (CIA World Factbook 2002)
C16647	Grenada	Country	Grenada|308|GD|GJ|GRD	An island between the Caribbean Sea and Atlantic Ocean, north of Trinidad and Tobago. (CIA World Factbook 2002)
C16648	Tissue_Growth	Multicellular_Process	Tissue Growth|Growth	The process of growing; progressive development. (NCI)
C16649	Embryogenesis	Developmental_Process	Embryogenesis	Embryogenesis is the developmental process by which an embryo is formed and developed.  The process begins following fertilization and involves cellular differentiation, leading to the completion of the embryonic stage.
C16650	GTPase	Hydrolase	GTPase|Guanosinetriphosphatase	Proteins that hydrolyze guanine triphosphate to yield guanine diphosphate. This is a class of proteins that belongs to a family of high energy phosphate hydrolases. Members of this family play major roles in biological signal transduction pathways.
C16651	Guadeloupe	Country	Guadeloupe|312|GLP|GP	Islands in the eastern Caribbean Sea, southeast of Puerto Rico. (CIA World Factbook 2002)
C16652	Guam	Country	Guam|316|GQ|GU|GUM	Island in the North Pacific Ocean, about three-quarters of the way from Hawaii to the Philippines. (CIA World Factbook 2002)
C16653	Guanylate_Cyclase	Lyase	Guanylate Cyclase	Guanylate cyclase (GC) is an enzyme that converts GTP to the second messenger cyclic GMP (cGMP). There are two forms: plasma membrane GCs that are receptors for hormones, and intracellular soluble GCs that are activated by the gaseous second messenger nitric oxide (NO). EC 4.6.1.2
C16654	Guatemala	Country	Guatemala|320|GT|GTM	A country in Central America, bordering the Caribbean Sea, between Honduras and Belize and bordering the North Pacific Ocean, between El Salvador and Mexico. (CIA World Factbook 2002)
C16655	Guinea	Country	Guinea|324|GIN|GN|GV	A country in Western Africa, bordering the North Atlantic Ocean, between Guinea-Bissau and Sierra Leone. (CIA World Factbook 2002)
C16656	Guinea-Bissau	Country	Guinea-Bissau|624|GNB|GW|PU	A country in Western Africa, bordering the North Atlantic Ocean, between Guinea and Senegal. (CIA World Factbook 2002)
C16657	Guyana	Country	Guyana|328|GUY|GY	A country in Northern South America, bordering the North Atlantic Ocean, between Suriname and Venezuela. (CIA World Factbook 2002)
C16658	Gynecology	Internal_Medicine	Gynecology|GYN	Gynecology; the branch of medicine that deals with the diseases and hygiene of women.
C16659	Oncogene_H-Ras	HRAS_Gene	Oncogene H-Ras|HRAS|HRAS1|Harvey Rat Sarcoma Viral Oncogene Homolog|v-Ha-RAS Harvey Rat Sarcoma Viral Oncogene Homolog	The oncogene (v-ras-Ha or v-Ha-ras) of Harvey murine sarcoma virus (Ha-MuSV) encodes a transforming protein.
C16660	Haiti	Country	Haiti|332|HA|HT|HTI	A country comprising the western one-third of the island of Hispaniola, between the Caribbean Sea and the North Atlantic Ocean, west of the Dominican Republic. (CIA World Factbook 2002)
C16661	Disabled_Population	Population_Group	Disabled Population|Disabled	Groups with similar restrictions or lack or ability to perform physical or mental activities in a manner or within the range considered normal for a human being.
C16662	Harding-Passey_Malignant_Melanoma	Experimental_Malignant_Melanoma	Harding-Passey Malignant Melanoma|Harding-Passey Melanoma	A melanin-forming tumor that arose spontaneously in a non-inbred mouse, and that is transplantable to mice of many strains but does not ordinarily metastasize. (dictionarybarn.com)
C16663	Health_Behavior	Personal_Behavior	Health Behavior|Health and Behavior	human attitudes and behaviors related to health; e.g., diet, exercise, care-seeking, substance avoidance, therapy compliance, etc.
C16664	Health_Education	Patient_or_Public_Education	Health Education
C16665	Medicare	Insurance	Medicare	A program under the U.S. Social Security Administration that reimburses hospitals and physicians for medical care provided to qualifying people over 65 years old.
C16666	Health_Care_Provider	Provider	Health Care Provider	A person who is trained and licensed to give health care. Also, a place licensed to give health care. Doctors, nurses, hospitals, skilled nursing facilities, some assisted living facilities, and certain kinds of home health agencies are examples of health care providers. (Medicare Glossary)
C16667	Health_Physics	Environmental_Health_Sciences	Health Physics
C16668	Health_Policy	Policy	Health Policy	information leading to decisions on the formation of policies pertaining to the health care system.
C16669	Health_Status	Personal_Attribute	Health Status	The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures. (On-line Medical Dictionary)
C16670	Hearing	Sensory_Process	Hearing	The auditory faculty, the perception of sound by the ear.
C16671	Heat_Shock_27kD_Protein-1	Heat_Shock_Protein	Heat Shock 27 kD Protein 1|28 kDa Heat Shock Protein|Estrogen-regulated 24 kDa Protein|HSPB1|Heat Shock Protein 27|Stress-responsive Protein 27	Heat-shock proteins belong to a large group stress proteins, induced in response to environmental challenges and developmental transitions.  Involved in stress resistance and actin organization, synthesis of HSP27 is correlated with the acquisition of thermotolerance.  HSP27 belongs to the HSP20 family and shows sequence similarity to alpha-crystallins.  Cytoplasmic HSP27 associates with alpha- and beta-tubulin, and with interphase and mitotic microtubules.  HSP27 translocates to the nucleus during heat shock and is phosphorylated on exposure to PKC activators and heat shock.  (from OMIM 602195, Swiss-Prot P04792, and NCI)
C16672	Heat_Shock_Protein	Stress-Induced_Protein	Heat Shock Protein|HSP|Heat Shock Proteins	A family of highly-conserved proteins that are synthesized in response to hyperthermia (heat shock), hypoxia, or other stresses that appear to increase cellular thermal tolerance and enable cells to recover from stress. Some heat shock proteins may protect other proteins from denaturation, degradation or perform functions essential to cell survival under these conditions.
C16673	Hematology	Internal_Medicine	Hematology|HMT	The branch of medicine that deals with the blood and blood-forming organs and the diseases thereof.
C16674	Hematopoiesis	Histogenesis	Hematopoiesis|Hematopoietic Cellular Control Mechanisms|hematopoiesis	Haematopoiesis is a process of blood formation and more specifically formation of blood cells that are all derived from haematopoietic stem cells. (from Wikipedia)
C16675	Heme_Protein	Metalloprotein	Heme Protein	Proteins that contain a metal-containing cofactor that consists of an iron atom contained in the center of a large heterocyclic organic ring called a porphyrin. One of the main functions of heme proteins is the retention of molecular oxygen to deliver it for enzymatic reactions. As a result, many heme-containing enzymes are located in the mitochondrion.
C16676	Hemoglobin	Heme_Protein	Hemoglobin|HGB|hemoglobin	The red respiratory protein of erythrocytes, consisting of approximately 3.8% heme and 96.2% globin (64.5 KD), which as oxyhemoglobin (HbO2) transports oxygen from the lungs to the tissues where the oxygen is readily released and HbO2 becomes Hb.
C16677	Canonical_HMG_Protein	DNA_Binding_Protein	Canonical HMG Protein|Archetypal HMG Protein|HMG Motif Protein|HMG Nuclear Protein|HMG Protein|High Mobility Group Protein	The High Mobility Group (HMG) proteins were originally isolated from mammalian cells, named according to their electrophoretic mobility in polyacrylamide gels, and were arbitrarily classed as a specific type of non-histone proteins based on the observation that they are ubiquitous to mammalian cells, that they share certain physical properties, and that they are associated with isolated chromatin. Those mammalian proteins considered to be Canonical HMG proteins are now subdivided into 3 superfamilies: the HMGB (formerly HMG-1/-2) family, the HMGN (formerly HMG-14/-17) family, and the HMGA (formerly HMG-I/Y/C) family.  Each HMG family has a characteristic functional sequence motif. (www.informatics.jax.org/mgihome/nomen/genefamilies/hmgfamily.shtml)
C16678	Histocompatibility_Antigen_Class_I	Retired_Concepts	Histocompatibility Antigen, Class I|Complex Class 1
C16679	Histocompatibility_Antigen_Class_II	Retired_Concepts	Histocompatibility Antigen, Class II|Major Histocompatibility Complex Class II
C16680	Histological_Techniques	Techniques	Histological Technique|Histological Techniques	Technique used for the study of the microanatomy of tissues and their cellular structure; usually involves microscopic examination of tissue slices.(NCI2005)
C16681	Histology	Biological_Sciences	Histology|Microanatomy|histology	The study of the structure of the cells and their arrangement to constitute tissues and, finally, the association among these to form organs.  In pathology, the microscopic process of identifying normal and abnormal morphologic characteristics in tissues, by employing various cytochemical and immunocytochemical stains.
C16682	Histone_Deacetylase	Deacetylase	Histone Deacetylase|HDAC	Histone acetylation and deacetylation alternately exposes and occludes DNA to transcription factors. Histone deacetylation is catalyzed by the histone deacetylases.  There are at least 2 classes of HDACs, class I consisting of proteins homologous to yeast Rpd3 (e.g., HDAC1, HDAC2, and HDAC3) and class II consisting of proteins homologous to yeast Hda1 (e.g., HDAC4 and HDAC6). (from OMIM)
C16683	Histone-H1	Histone	Histone H1	Linker Histone H1 interacts with DNA between nucleosome units in mediating chromatin compaction into higher order structures. Histones are basic nuclear proteins responsible for the nucleosome structure of eukaryotic chromatin. Repeating nucleosome units contain two molecules each of core Histones H2A, H2B, H3, and H4 that form an octamer complex around which approximately 146 base pairs of DNA is wrapped. (NCI)
C16684	Histone-H2A	Histone	Histone H2A	Slightly lysine rich histone.  One of four histones assembled into a nucleosomal core octamer.  Various posttranslationally modified forms and variants exist.  Combines with histone H2B in a heterodimer; two H2A/H2B dimers are incorporated in the nucleosomal octamer.
C16685	Histone-H3	Histone	Histone H3	Arginine rich histone.  One of four histones assembled into a nucleosomal core octamer.  Various posttranslationally modified forms and variants exist.  Combines with histone H4 in a heterotetramer of composition (H3)2(H4)2; one tetramer is incorporated in the nucleosomal octamer.
C16686	Histone-H4	Histone	Histone H4	Arginine rich histone.  One of four histones assembled into a nucleosomal core octamer.  Various posttranslationally modified forms and variants exist.  Combines with histone H3 in a heterotetramer of composition (H3)2(H4)2; one tetramer is incorporated in the nucleosomal octamer.
C16687	Histone	Structural_Protein	Histone	Major protein component of chromatin.  Highly conserved basic proteins, originally classified into classes based on the relative amounts of arginine and lysine in each protein.  The various classes are now termed H1, H2A, H2B, H3, and H4.  In chromatin, they are found in an octamer, containing two each of H2A, H2B, H3, and H4, complexed with DNA in nucleosomes.  The histones in the octamer complex are also known as the core histones.  The H1 class of histones, termed the linker histones, is loosely associated with the nucleosome.
C16688	HIV_Antibody	Antibody	HIV Antibody|HIV antibody	A substance produced by certain white blood cells in reaction to contact with HIV, the human immunodeficiency virus.
C16689	HIV_Envelope_Protein-gp120	ENV_Protein	HIV Envelope Protein gp120|gp120 ENV Glycoprotein	A protein produced by the human immunodeficiency virus that functions as a viral anti-receptor attachment protein. The protein is localized to the viral envelope and mediates fusion between viral and cellular membranes.
C16690	HIV_Envelope_Protein-gp41	ENV_Protein	HIV Envelope Protein gp41	A protein produced by the human immunodeficiency virus that functions as a viral attachment protein on the viral envelope. This transmembrane protein is a glycoprotein that non-covalently anchors gp120 to the virus particle.
C16691	HLA-A2_Antigen	MHC_Class-I_Protein	HLA-A2 Antigen|HLA Class I Histocompatibility Antigen, A-2 Alpha Chain|HLA-A|HLA-A Class I Antigen 2|HLA-A Histocompatibility Type Antigen 2|HLA-A2|Major Histocompatibility Complex, Class I, A2 Antigen	Encoded by human HLA-A (A2 allele) Gene (HLA Family), HLA-A2 Antigen is a 365-aa 41-kD class I alpha heavy chain glycoprotein heterodimerized with 11.6-kD beta-2 microglobulin. HLA-A protein organization includes a signal peptide, extracellular alpha1, 2, and 3 domains (90-aa each), a transmembrane region, and a cytoplasmic tail. Polymorphic alpha1 and 2 domains determine peptide binding specificity. Ig-like alpha3 mediates CD8 binding on cytotoxic T-lymphocytes. In the immune response, HLA antigens mediate antigen presentation to TCR. HLA-A2 subtypes are associated with decreased risk of HIV-1 infection and increased frequency of early-onset Alzheimer disease.  (from LocusLink, Swiss-Prot, OMIM, and NCI)
C16692	HLA-DR_Antigen	MHC_Class-II_Protein	HLA-DR Antigen|HLA-DR	Encoded by multiple HLA-DRA and HLA-DRB genes in a complex variable 5 cM region of MHC between HLA-B and -D, HLA-DR Antigens are Class II histocompatibility transmembrane glycoprotein heterodimers of alpha (heavy, 35-kD) and beta (light, 27-kD) chains. Located predominantly on B cells and macrophages, HLA-DR antigens function in antigen presentation to regulatory T cells in the immune response and in self/nonself discrimination. Invariant alpha and polymorphic beta chains have glycosylated N-termini, hydrophobic membrane regions, and hydrophilic C-termini. The heterodimer consists of 4 extracellular domains; invariant alpha-1, polymorphic N-terminal beta-1, and conserved Ig-like alpha-2 and beta-2. Alpha-1 and alpha-2 contain disulfide loops. Beta-1 contains 2 small variable regions. Alpha sequences have relatively simple structure; beta chains carry the major polymorphic determinants. (NCI)
C16693	HMGN2_Protein	HMGN_Family_Protein	HMGN2 Protein|Chromosomal Protein, Nonhistone, HMG17|HMG-17|HMG17|HMGN2|High Mobility Group Nucleosomal Binding Protein 2|High Mobility Group Protein 17|High Mobility Group Protein N2|High-Mobility Group (Nonhistone Chromosomal) Protein 17|High-Mobility Group Nucleosomal Binding Domain|High-Mobility Group Nucleosomal Binding Domain 2|High-Mobility Group Nucleosome Binding Domain 2|MGC5629|Nonhistone Chromosomal Protein HMG-17|Nonhistone Chromosomal Protein HMG1|Nonhistone Chromosomal Protein HMG17	HMGN2 enhances the transcriptional potential of chromatin when incorporated into nucleosomes during, but not after, chromatin assembly on replicating DNA. Two molecules of HMGN2 can bind to nucleosome cores, independently of the underlying DNA sequence, in a cooperative fashion to limit nucleosome mobility and stabilize the structure of the nucleosome core without stabilizing the higher order chromatin structure. By modifying the structure of nucleosomes, the proteins affect the local structure of the chromatin fiber leading to an increase in the rate of transcriptional elongation but not initiation. (Semin Cell Biol 1995 Aug;6(4):247-55)
C16694	Honduras	Country	Honduras|340|HN|HND|HO	A country in Central America, bordering the Caribbean Sea, between Guatemala and Nicaragua and bordering the North Pacific Ocean, between El Salvador and Nicaragua. (CIA World Factbook 2002)
C16695	Hong_Kong	Country	Hong Kong|344|HK|HKG	A special administrative region of China, bordering the South China Sea and China. (CIA World Factbook 2002)
C16696	Hospital	Healthcare_Facility	Hospital|HOSP	An institution that provides medical, surgical, or psychiatric care and treatment for the sick or the injured.
C16697	Host-Parasite_Relationship	Pathologic_Process	Host-Parasite Relationship	The interactions between two organisms, one of which lives at the expense of the other. (NCI)
C16698	Human_Genetics	Genetics	Human Genetics
C16699	Hungary	Country	Hungary|348|HU|HUN	A country in Central Europe, northwest of Romania. (CIA World Factbook 2002)
C16700	Hybridoma	Specimen	Hybridoma	A tumor of hybrid cells used in the in vitro production of specific monoclonal antibodies; produced by fusion of an established tissue culture line of lymphocyte tumor cells (e.g., mouse plasmacytoma cells) and specific antibody-producing cells (e.g., splenocytes from specifically immunized mice); fusions are accomplished by use of polyethylene glycol or other methods.
C16701	Hydrolase	Enzyme	Hydrolase|Hydrolases	Enzymes (EC class 3) cleaving substrates with addition of H2O at the point of cleavage; e.g., esterases, phosphatases, nucleases, peptidases. SYN hydrolyzing enzymes.
C16702	Hydrolysis	Biochemical_Reaction	Hydrolysis|hydrolysis	A chemical reaction in which a water molecule is added to a compound. This addition often involves the splitting or cleavage of the molecule. The hydroxyl group is incorporated into one fragment of the compound and the hydrogen atom in the other.
C16703	Hypoxanthine_Phosphoribosyltransferase	Glycosyltransferase	Hypoxanthine Phosphoribosyltransferase|EC 2.4.2.8|HPRT	Cytoplasmic Hypoxanthine Phosphoribosyltransferases (Purine/Pyrimidine Phosphoribosyltransferase Family) catalyze the conversion of 5-phosphoribosyl-1-pyrophosphate and hypoxanthine, guanine, or 6-mercaptopurine to the corresponding 5'-mononucleotides and pyrophosphate.  The enzyme is important in purine biosynthesis as well as central nervous system functions. (NCI)
C16704	Iceland	Country	Iceland|352|IC|IS|ISL	A country in Northern Europe, island between the Greenland Sea and the North Atlantic Ocean, northwest of the UK.  (CIA World Factbook 2002)
C16710	Immunity	Immune_Function	Immunity	Adequacy of natural and acquired appropriately targeted resistance to internal and external antigens.
C16711	Cell-Mediated_Immunity	Immunity	Cell-Mediated Immunity|Cell Mediated Immunity|Cell Mediated Immunology|Cellular Immunity	Those manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.
C16712	Humoral_Immunity	Immunity	Humoral Immunity	Immune processes mediated by antibodies
C16713	Immunochemistry	Chemistry	Immunochemistry|IC	The field of chemistry concerned with chemical processes in immunology (such as chemical studies of antigens and antibodies).
C16714	Immunoenzyme_Techniques	Immunologic_Techniques	Immunoenzyme Techniques	Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens (From MESH 2001).
C16715	Immunogenetics	Genetics	Immunogenetics	A sub-field of genetics that uses both genetic and immunological analyses to study the genetics behind antibody formation and the immune response. (Biotech Life Science Dictionary)
C16716	Idiotype	Miscellaneous_Molecular_Biology_Terms	Idiotype
C16717	Immunoglobulin_Heavy_Chain	Protein_Complex_Subunit	Immunoglobulin Heavy Chain	A protein complex that consists of two heavy chains (gamma, alpha, delta, epsilon or mu). The larger of the two immunoglobulin chain types determines the immunoglobulin class (G, A, D, E or M, respectively). The heavy chain molecules exhibit the same structure and composition, which consists of constant, variable, and hypervariable regions.
C16718	Immunoglobulin_Light_Chain_Kappa	Immunoglobulin_Light_Chain	Immunoglobulin Light Chain, Kappa	Immunoglobulin Light Chain Kappa is one of two Ig light chain types. Each Ig molecule is typically composed of two heavy chains and two light chains. Ig kappa light chains contain a variable and a constant region. Kappa light chains are encoded by multiple V, J, and C gene segments, which are separated in the genomes of cells undifferentiated with regard to antibody gene expression. Diversity in the kappa light chain V region arises during differentiation of an activated (kappa-type) antibody-producing B-cell from variable recombination of kappa V genes with kappa J genes and somatic point mutation, which plays a major role in antibody diversity. (from OMIM and NCI)
C16719	Immunoglobulin_Light_Chain_Lambda	Immunoglobulin_Light_Chain	Immunoglobulin Light Chain, Lambda	Each antibody molecule is composed of two identical heavy chains and two identical light chains. Immunoglobulin Light Chain Lambda is one of two Ig light chain types. Lambda light chains are encoded by multiple V, J, and C gene segments, which are separated in the genome. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink, OMIM, and NCI)
C16720	Immunoglobulin_Light_Chain	Protein_Complex_Subunit	Immunoglobulin Light Chain	A protein complex that consists of two light chains (kappa and lambda). The light chain molecules are of the same structure and composition, consisting of constant, variable, and hypervariable regions.
C16722	Immunohistochemistry	Histological_Techniques|Immunologic_Techniques	Immunohistochemistry|Cell/Tissue, Immunohistochemistry|IHC	An assay that shows specific antigens by the use of markers that are either fluorescent dyes or enzymes. In these techniques an antibody is used to link a cellular antigen specifically to a stain that can be more readily seen with a microscope. Detection of antigens in tissues is known as immunohistochemistry, while detection in cultured cells is generally termed immunocytochemistry.
C16723	Immunologic_Techniques	Research_Techniques	Immunologic Techniques|Immunological Techniques	Laboratory techniques involving interaction of antigens with specific antibodies.(NCI2005)
C16724	Immunoprecipitation	Immunologic_Techniques	Immunoprecipitation|IP	Antigen aggregation with antibody, in the right ratios, to cause precipitation.
C16725	Immunoprotein	Protein_Organized_by_Function	Immunoprotein	A complex consisting of an immune component and a protein. This complex molecule modulates a variety of activities that are regulated by the immune system.
C16726	Incidence	Vital_Statistics	Incidence|incidence	The number of new cases of a disease diagnosed each year.
C16727	India	Country	India|356|IN|IND	A country in Southern Asia, bordering the Arabian Sea and the Bay of Bengal, between Burma and Pakistan.  (CIA World Factbook 2002)
C16728	Indonesia	Country	Indonesia|360|ID|IDN	A country in Southeastern Asia, comprising the archipelago between the Indian Ocean and the Pacific Ocean.  (CIA World Factbook 2002)
C16729	Infant_Mortality	Mortality	Infant Mortality|Infant Mortality Total	Any disease or condition resulting in postnatal death before age 1 yr. (NCI)
C16730	Developmental_Psychology_Infant	Developmental_Psychology_General	Developmental Psychology, Infant
C16731	Newborn	Age_Group	Newborn|Neonate	An infant during the first month after birth.
C16732	Information_Dissemination	Information_Resources_Management	Information Dissemination	For information to be useful, not only does it need to be made available at the right time to those who need it such as policy makers, program planners, and health professionals, and patients but it has to be in the right form.  Information Dissemination includes both research into means of information distribution and the actual distribution of information.
C16733	Information_Sciences	Technology	Information Sciences|Information Technology	The sciences concerned with gathering and manipulating and storing and retrieving and classifying recorded information.
C16734	Information_Storage_and_Retrieval	Information_Resources_Management	Information Storage and Retrieval|Information Processing/Storage/Retrieval	A branch of computer or library science relating to the storage, locating, searching, and selecting, upon demand, relevant data on a given subject.
C16735	Informed_Consent	Personal_Behavior	Informed Consent|informed consent	A process in which a person learns key facts about a clinical trial, including potential risks and benefits, before deciding whether or not to participate in a study.  Informed consent continues throughout the trial.
C16736	Infrared_Radiation	Nonionizing_Radiation	Infrared Radiation|Radiation, Infrared	Electromagnetic radiation with wavelengths between 750 nanometers and 1 millimeter, between those of visible light and microwaves. This portion of the electromagnetic spectrum can usually be sensed as heat.
C16737	Implantable_Pump	Drug_Delivery_System	Implantable Pump|implantable pump	A small device installed under the skin to administer a steady dose of drugs.
C16738	Inhaler	Drug_Packaging_Device	Inhaler|INHALER|INHL	A device by means of which a medicinal product can be administered by inspiration through the nose or the mouth.
C16739	Artificial_Insemination	Reproductive_Techniques	Artificial Insemination	Introduction of semen into the uterus or oviduct by other than natural means.  One of various assisted reproductive Technologies used to treat infertility.  Performed by intrauterine insemination with semen presented in one of various forms: whole ejaculate, split ejaculate using the first portion containing the greatest sperm density and motility, or washed semen samples. (Merck Manual 16 Ed)
C16740	Institute_of_Medicine	Professional_Organization_or_Group	Institute of Medicine|NAS/IOM	As part of the National Academy of Science, identifies, for study and analysis, important issues and problems that relate to health and medicine. The Institute initiates and conducts studies of national policy and planning for health care and health-related education and research; it also responds to requests from the federal government and other agencies for studies and advice.
C16741	Institutional_Review_Board	Professional_Organization_or_Group	Institutional Review Board|IRB	A group of scientists, doctors, clergy, and consumers at each health care facility that participates in a clinical trial.  IRBs are designed to protect study participants.  They review and must approve the action plan for every clinical trial.  They check to see that the trial is well designed, does not involve undue risks, and includes safeguards for patients.
C16742	Instrumentation	Diagnostic_Therapeutic_and_Research_Equipment	Instrumentation|Instrument	Any object, or item of electrical or electronic equipment, which is designed to carry out a specific function or set of functions.
C16743	Insulin-Like_Growth_Factor-1	Insulin-Like_Growth_Factor	Insulin-Like Growth Factor 1|IGF-I|IGF1|Insulin-Like Growth Factor-I|Somatomedin C	Elevated serum levels of insulin-like growth factor-1 (IGF-1) may identify premenopausal women who are likely to develop breast cancer before age 50. (from Int J Cancer 2000;88:828-832 via Medscape)
C16744	Insulin-Like_Growth_Factor-2	Insulin-Like_Growth_Factor	Insulin-Like Growth Factor 2|IGF-II|IGF2|Somatomedin A	Insulin-like growth factors I and II, also known as somatomedin C and somatomedin A, respectively, are single chain polypeptides which share an amino acid sequence homology of about 47% with insulin and about 31% with relaxin and with them comprise the insulin family of polypeptide growth factors. Their functions include mediation of growth hormone action, stimulation of growth of cultured cells, stimulation of the action of insulin, and involvement in development and growth. They appear to be autocrine regulators of cell proliferation.
C16745	Insurance	Medical_Economics	Insurance	A mechanism for guarding against financial aspects of risk by making payments in the form of premiums to an insurance company, which pays an agreed-upon sum to the insured in the event of loss.
C16746	Insurance_Health_Reimbursement	Insurance_and_Payment_Issues	Insurance, Health, Reimbursement|Third Party Payment
C16747	Transmembrane_Protein	Membrane_Protein	Transmembrane Protein|Integral Membrane Protein|Intrinsic Membrane Protein	A protein that is an integral membrane protein with a transmembrane region.
C16748	Integrin	RGD_Receptor	Integrin|Extracellular Matrix, Integrins	Integrins are transmembrane glycoprotein receptors that mediate cell-matrix or cell-cell adhesion, and transduce signals that regulate gene expression and cell growth.  They are heterodimeric molecules consisting of noncovalently linked alpha and beta subunits. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Both alpha and beta subunits display a cytoplasmic domain that interacts with the cytoskeleton (and possibly signaling molecules), a transmembrane region, and a large extracellular domain that interacts with the extracellular matrix. (from OMIM 147557)
C16749	Internal_Medicine	Medical_Specialty	Internal Medicine|Medicine, Internal
C16750	Interphase	Cell_Cycle_Stage	Interphase	The interval between two successive cell divisions during which the chromosomes are not individually distinguishable. Interphase is considered the resting stage of the cell.
C16751	Interview	Survey	Interview	A conversation with an individual regarding his or her background and other personal and professional details, opinions on specific subjects posed by the interviewer, etc.
C16752	Thyroid_Peroxidase	Oxidoreductase	Thyroid Peroxidase|EC 1.11.1.8|Iodide Peroxidase|Iodinase|Iodoperoxidase (Heme Type)|Iodotyrosine Deiodase|Iodotyrosine Deiodinase|Monoiodotyrosine Deiodinase|Thyroperoxidase|Tyrosine Iodinase	Human thyroid peroxidase protein (933 aa, ~103 kDa isoform) is encoded by the human thyroid peroxidase (TPO) gene. This protein is the primary enzyme involved in thyroid hormone synthesis.
C16753	Gated_Ion_Channel	Ion_Channel	Gated Ion Channel
C16754	Ion_Channel	Other_Anatomic_Concept	Ion Channel	A transmembrane pore that presents a hydrophilic channel for ions to cross a lipid bilayer down their electrochemical gradients.  Some degree of ion specificity is usually observed and typically a million ions per second may flow. Channels may be permanently open, like the potassium leak channel or they may be voltage gated, like the sodium channel or ligand gated like the acetylcholine receptor. (On-line Medical Dictionary)
C16755	Iran	Country	Iran|364|IR|IRN	A country in the Middle East, bordering the Gulf of Oman, the Persian Gulf, and the Caspian Sea, between Iraq and Pakistan.  (CIA World Factbook 2002)
C16756	Iraq	Country	Iraq|368|IQ|IRQ|IZ	A country in the Middle East, bordering the Persian Gulf, between Iran and Kuwait. (CIA World Factbook 2002)
C16757	Ireland	Country	Ireland|372|EI|IE|IRL	A country in Western Europe, occupying five-sixths of the island of Ireland in the North Atlantic Ocean, west of Great Britain. (CIA World Factbook 2002)
C16758	Isoelectric_Focusing	Gel_Electrophoresis	Isoelectric Focusing|Fractionation, Isoelectric Focusing	A type of gel electrophoresis in which charged molecules travel through a pH gradient.  The molecules will come to stop at the point where the net charge on the molecule is equal to that of the surrounding gel.
C16759	Isomerase	Enzyme	Isomerase	An enzyme that transfers functional groups to catalyze the geometric or structural rearrangement of atoms within a given molecule to form an isomer of the original molecule.
C16760	Israel	Country	Israel|376|IL|IS|ISR	A country in the Middle East, bordering the Mediterranean Sea, between Egypt and Lebanon. (CIA World Factbook 2002)
C16761	Italy	Country	Italy|380|IT|ITA	A country in Southern Europe, occupying a peninsula extending into the central Mediterranean Sea, northeast of Tunisia. (CIA World Factbook 2002)
C16762	Cote_dIvoire	Country	Cote d'Ivoire|384|CI|CIV|IV|Ivory Coast	A country in Western Africa, bordering the North Atlantic Ocean, between Ghana and Liberia. (CIA World Factbook 2002)
C16763	Jamaica	Country	Jamaica|388|JAM|JM	An island in the Caribbean Sea, south of Cuba. (CIA World Factbook 2002)
C16764	Japan	Country	Japan|392|JA|JP|JPN	A country in Eastern Asia, occupying an island chain between the North Pacific Ocean and the Sea of Japan, east of the Korean Peninsula. (CIA World Factbook 2002)
C16765	Jordan	Country	Jordan|400|JO|JOR	A country in the Middle East, northwest of Saudi Arabia. (CIA World Factbook 2002)
C16766	Oncogene_K-Ras	KRAS2_Gene	Oncogene K-Ras|KRAS|KRAS2|Ki-RAS|Oncogene, K-Ras|Oncogene, K-Ras-2|RASK2|v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog	Human Oncogene K-Ras is a mutated variant of KRAS2 Gene, which encodes two alternative isoforms of monomeric p21 K-RAS protein, a monomeric GTPase involved in transmembrane signal transduction that alternates between inactive GDP-bound and active GTP-bound forms. K-Ras is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein. Mitogen-stimulated RAS stabilizes MYC protein and enhances MYC accumulation by the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC. Implicated in a variety of human tumors, mutations of specific amino acids activate RAS to transform cells. KRAS is involved in malignancy much more often than is HRAS. Oncogene K-Ras disrupts normal cell function.
C16767	Kallikrein	Serine_Protease	Kallikrein|KLK|AB|NCI	Serine proteases that are found in many different tissues and fluids in the body. The kallikrein protease family is comprised of potent vasodilators and hypotensives agents, thus they play important roles in inflammation and blood pressure. These enzymes normally reside in the body as inactive prekallikreins, which are activated by Hageman factor.
C16768	Karyotyping	Cytogenetic_Analysis	Karyotyping|Genetics, Karyotyping	The preparation, analysis, and interpretation of a karyotype, the representation of the chromosome set of a cell.
C16769	Kenya	Country	Kenya|404|KE|KEN	A country in Eastern Africa, bordering the Indian Ocean, between Somalia and Tanzania. (CIA World Factbook 2002)
C16770	Kinetics	Physics	Kinetics	Kinetics is the branch of mechanics concerned with the forces that cause motions of bodies and govern the rates at which molecules and compounds react.
C16771	Kyrgyzstan	Country	Kyrgyzstan|417|KG|KGZ	A country in Central Asia, west of China. (CIA World Factbook 2002)
C16772	Knowledge_Attitudes_Behaviors	Epidemiological_Factors	Knowledge, Attitudes, Behaviors	The consideration of knowledge, attitude, or behavior as variables in disease processes such as incident, transmission, and control.
C16773	North_Korea	Country	North Korea|408|KN|KP|PRK	A country in Eastern Asia, occupying the northern half of the Korean Peninsula, bordering the Korea Bay and the Sea of Japan, between China and South Korea. (CIA World Factbook 2002)
C16774	South_Korea	Country	South Korea|410|KOR|KR|KS|Republic of Korea	A country in Eastern Asia, occupying the southern half of the Korean Peninsula, bordering the Sea of Japan and the Yellow Sea. (CIA World Factbook 2002)
C16775	Kuwait	Country	Kuwait|414|KU|KW|KWT	A country in the Middle East, bordering the Persian Gulf, between Iraq and Saudi Arabia. (CIA World Factbook 2002)
C16776	Laboratory_Animal_Science	Technology	Laboratory Animal Science
C16777	LacZ_Gene	Reporter_Gene	LacZ Gene|LacZ	The lacZ gene is a popular reporter gene in transfection experiments because its product, b-galactosidase, is very stable, resistant to proteolytic degradation, and easily assayed.
C16778	Laminin	Cell_Adhesion_Molecule	Laminin	A family of basement membrane extracellular basement proteins. Each molecule is composed of 3 nonidentical chains which are arranged in a cross-shaped structure. There are at least 5 alpha, 4 beta, and 3 gamma laminin genes.
C16779	Language	Social_Concepts	Language|LNG|Language Name	A systematic means of communicating by the use of sounds or conventional symbols.
C16780	Lao_Peoples_Democratic_Republic	Country	Lao People's Democratic Republic|418|LA|LAO|Laos	A country in Southeastern Asia, northeast of Thailand, west of Vietnam. (CIA World Factbook 2002)
C16781	Laryngoscopy	Endoscopy	Laryngoscopy|laryngoscopy	(LAIR-in-GOSS-kuh-pee) Examination of the larynx (voice box) with a mirror (indirect laryngoscopy) or with a laryngoscope (direct laryngoscopy).
C16782	Laser	Medical_Device	Laser|Electromagnetic, Laser|Radiation, Laser|laser	(LAY-zer) A device that concentrates light into an intense, narrow beam used to cut or destroy tissue. It is used in microsurgery, photodynamic therapy, and for a variety of diagnostic purposes.
C16783	Latvia	Country	Latvia|428|LG|LV|LVA	A country in Eastern Europe, bordering the Baltic Sea, between Estonia and Lithuania. (CIA World Factbook 2002)
C16784	Lebanon	Country	Lebanon|422|LB|LBN|LE	A country in the Middle East, bordering the Mediterranean Sea, between Israel and Syria. (CIA World Factbook 2002)
C16785	Lectin	Ligand_Binding_Protein	Lectin|lectin	Complex molecules that contain both protein and sugar. Lectins specifically bind to the branching sugar molecules of glycoproteins and glycolipids on cell surfaces to cause biochemical changes. They are often classified according to either the saccharide or sugar specificity.
C16786	Law	Sociology	Law|Legislation
C16787	Lesotho	Country	Lesotho|426|LS|LSO|LT	A country in Southern Africa, an enclave of South Africa. (CIA World Factbook 2002)
C16788	LD-50	Attributes_of_Chemicals	LD-50|Lethal Dose - 50%	lethal dose (LD) - 50%. the median lethal dose.  the dose of a chemical or biologic preparation (e.g., a bacterial exotoxin or a suspension of bacteria) that is likely to cause death in 50% of the animals being tested; it varies in relation to the type of animal and the route of administration; (the absolute lethal dose is LD100, and minimal lethal dose is LD05).
C16789	Integrin_Alpha-X	Cell_Adhesion_Molecule	Integrin Alpha X|Alphax Integrin Chain|Antigen Cd11c (P150), Alpha Polypeptide|Axb2|CD11c|Cr4|ITGAX|Leukocyte Surface Antigen P150, 95|Myeloid Membrane Antigen, Alpha Subunit	Leukocyte Surface Antigen p150,95 has a unique alpha chain (CD11c) and shares a beta subunit (CD18) with two other members of the leukocyte adhesion molecule family.  The alpha subunit has an extracellular domain containing ten potential glycosylation sites, a transmembrane domain, and a short cytoplasmic tail.  It shows homology to alpha subunits of Platelet Glycoprotein IIb/IIIa, Vitronectin Receptor, and Fibronectin Receptor.  Receptors involved in cell-cell and cell-matrix interactions belong to a superfamily of integrin genes.  (from OMIM 151510 and NCI)
C16790	Mixed_Lymphocyte_Reaction_Test	Immunologic_Techniques	Mixed Lymphocyte Reaction Test|Mixed Lymphocyte Culture|Mixed T Cells, B Cells	Measure of histocompatibility at the HL-A locus. Peripheral blood lymphocytes from two individuals are mixed together in tissue culture for several days. Lymphocytes from incompatible individuals will stimulate each other to proliferate significantly (usually measured by tritiated thymidine uptake) whereas those from compatible individuals will not. In the one-way MLC test, the lymphocytes from one of the individuals are inactivated (usually by treatment with mitomycin C or radiation) thereby allowing only the untreated remaining population of cells to proliferate in response to foreign histocompatibility antigens.
C16791	Liberia	Country	Liberia|430|LBR|LI|LR	A country in Western Africa, bordering the North Atlantic Ocean, between Cote d'Ivoire and Sierra Leone. (CIA World Factbook 2002)
C16792	Library_Science	Information_Sciences	Library Science	The principles, practice, or study of library administration.
C16793	Libyan_Arab_Jamahiriya	Country	Libyan Arab Jamahiriya|434|LBY|LY|Libya	A country in Northern Africa, bordering the Mediterranean Sea, between Egypt and Tunisia. (CIA World Factbook 2002)
C16794	Liechtenstein	Country	Liechtenstein|438|LI|LIE|LS	A country in Central Europe, between Austria and Switzerland. (CIA World Factbook 2002)
C16795	Lifestyle	Behavior	Lifestyle	Lifestyle; a manner of living that reflects the person's values and attitudes.
C16796	Ligase	Enzyme	Ligase	Major class of enzymes that catalyze the linking together of two molecules (EC class 6) for example DNA ligases that link two fragments of DNA by forming a phosphodiester bond. (On-line Medical Dictionary)
C16797	Genetic_Linkage_Analysis	Molecular_Biology_Techniques	Genetic Linkage Analysis|Genetic Linkage|Linkage Analysis	The process of measuring the extent of crossovers between chromosomes as a gauge of the distance between genes.
C16798	Linkage_Disequilibrium	Miscellaneous_Molecular_Biology_Terms	Linkage Disequilibrium	The occurrence of some genes together, more often than would be expected based upon their physical separation, presumably because the combination confers some selective advantage.
C16799	Lithuania	Country	Lithuania|440|LH|LT|LTU	A country in Eastern Europe, bordering the Baltic Sea, between Latvia and Russia. (CIA World Factbook 2002)
C16800	LOD_Score	Genetic_Linkage_Analysis	LOD Score	The total relative probability, expressed on a logarithmic scale, that a linkage relationship exists among selected loci. LOD is an acronym for "logarithmic odds." (From MSH 2001)
C16801	Long-Term_Care_for_Elderly	Patterns_of_Care	Long-Term Care for Elderly	Long-term care encompasses a broad range of help with daily activities that chronically disabled individuals need for a prolonged period of time.
C16802	Luciferase	Oxidoreductase	Luciferase|Immunologic, Luciferase	An enzyme first isolated from firefly tails that catalyzes the production of light in the reaction between luciferin and ATP. (from On-line Medical Dictionary)
C16803	Luxembourg	Country	Luxembourg|442|LU|LUX	A country in Western Europe, between France, Belgium, and Germany. (CIA World Factbook 2002)
C16804	Lyase	Enzyme	Lyase	Trivial name applied, together with dehydratase, to certain hydro-lyases (EC class 4.2.1) catalyzing hydration-dehydration (On-line Medical Dictionary)
C16805	Lymphangiogram	Medical_Image	Lymphangiogram
C16806	Lymphography	Diagnostic_Radiology	Lymphography|Lymphangiography|lymphography	An x-ray study of lymph nodes and lymphatic vessels made visible by the injection of a special dye.
C16807	Macau	Country	Macao|446|MAC|MC|MO|Macau	A country in Eastern Asia, bordering the South China Sea and China. (CIA World Factbook 2002)
C16808	Madagascar	Country	Madagascar|450|MA|MDG|MG	A country in Southern Africa, occupying an island in the Indian Ocean, east of Mozambique. (CIA World Factbook 2002)
C16809	Magnetic_Resonance_Imaging	Imaging_Technique	Magnetic Resonance Imaging|MRI|Magnetic Resonance Imaging Scan|Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance|Nuclear Magnetic Resonance Imaging|magnetic resonance imaging|nuclear magnetic resonance imaging	(mag-NET-ik REZ-o-nans IM-a-jing) MRI. A procedure in which a magnet linked to a computer is used to create detailed pictures of areas inside the body.  Also called nuclear magnetic resonance imaging.
C16810	Magnetic_Resonance_Spectroscopy	Spectroscopy	Magnetic Resonance Spectroscopy|MRSI|Spectroscopy, MR|Spectroscopy, NMR|Spectroscopy, Nuclear Magnetic Resonance	Detection and measurement of the resonant spectra of molecular species in a tissue or sample.
C16811	Magnetoencephalography	Imaging_Technique	Magnetoencephalography|MEG	Magnetoencephalography (MEG) is the measurement of the magnetic fields produced by electrical activity in the brain, usually conducted externally, using extremely sensitive devices. The measurement of electric fields in the brain provides information about the localization of brain activity which is complementary to that provided by electroencephalography. (NCI2005)
C16812	Major_Histocompatibility_Complex_Gene	Gene	Major Histocompatibility Complex Gene	A group of linked loci, collectively termed H-2 complex in the mouse and HLA complex in humans, that codes for cell-surface histocompatibility antigens and is the principal determinant of tissue type and transplant compatibility.
C16813	Malawi	Country	Malawi|454|MI|MW|MWI	A country in Southern Africa, east of Zambia. (CIA World Factbook 2002)
C16814	Malaysia	Country	Malaysia|458|MY|MYS	A country in Southeastern Asia, occupying a peninsula and the northern one-third of the island of Borneo, bordering Indonesia and the South China Sea, south of Vietnam. (CIA World Factbook 2002)
C16815	Maldives	Country	Maldives|462|MDV|MV	A country in Southern Asia, occupying a group of atolls in the Indian Ocean, south-southwest of India. (CIA World Factbook 2002)
C16816	Mali	Country	Mali|466|ML|MLI	A country in Western Africa, southwest of Algeria. (CIA World Factbook 2002)
C16817	Malta	Country	Malta|470|MLT|MT	A country in Southern Europe, occupying islands in the Mediterranean Sea, south of Sicily (Italy). (CIA World Factbook 2002)
C16818	Mammography	Procedure	Mammography|mammography	(mam-OG-ra-fee) The use of x-rays to create a picture of the breast.
C16819	Manganese_Superoxide_Dismutase	Superoxide_Dismutase	Manganese Superoxide Dismutase|IPO-B|MNSOD|Manangese Superoxide Dismutase|Mitochondrial Superoxide Dismutase|Mitochondrial Superoxide Dismutase 2|Mn Superoxide Dismutase|Superoxide Dismutase 2	Encoded by human SOD2 Gene (Fe/Mn SOD Family), 222-aa 25-kDa (precursor) Manganese Superoxide Dismutase is a homotetrameric free radical scavenging indophenoloxidase in the mitochondrial matrix that is required for normal cell function. A first line of defense against toxic superoxide radical byproducts of the energy generating oxidative phosphorylation pathway, MnSOD maintains the integrity of mitochondrial respiratory chain enzymes susceptible to inactivation by superoxide. Reactive oxygen species and oxidative stress are implicated in a range of degenerative processes including ALS, ischemic heart disease, Alzheimer disease, Parkinson disease, and aging. Mitochondria are the chief source of reactive oxygen species in the cell. (NCI)
C16820	Manometry	Physical_Chemical_Techniques	Manometry|Biochemistry, Manometry	Measurement of the pressure or tension of liquids or gases.
C16821	Marine_Biology	Biology	Marine Biology|Marine/Aquatic Biology	The study of organisms that live in the sea or in other bodies of water.
C16822	Marshall_Islands	Country	Marshall Islands|584|MH|MHL|RM	A group of atolls and reefs in the North Pacific Ocean, about one-half of the way from Hawaii to Australia. (CIA World Factbook 2002)
C16823	Martinique	Country	Martinique|474|MB|MQ|MTQ	An island in the Caribbean Sea, north of Trinidad and Tobago. (CIA World Factbook 2002)
C16824	Maternal_Physiology	Physiology	Maternal Physiology	Study of the physiologic, biochemical, and anatomic changes that occur during pregnancy.
C16825	Mathematics	Physical_Sciences	Mathematics
C16826	Mauritania	Country	Mauritania|478|MR|MRT	A country in Northern Africa, bordering the North Atlantic Ocean, between Senegal and Western Sahara. (CIA World Factbook 2002)
C16827	Mauritius	Country	Mauritius|480|MP|MU|MUS	A country in Southern Africa, occupying an island in the Indian Ocean, east of Madagascar. (CIA World Factbook 2002)
C16828	Mayotte	Country	Mayotte|175|MF|MYT|YT	A country in Southern Africa, occupying an island in the Mozambique Channel, about one-half of the way from northern Madagascar to northern Mozambique. (CIA World Factbook 2002)
C16829	Mediastinoscopy	Endoscopy	Mediastinoscopy|MSC|endoscopic exploration of mediastinum|mediastinoscopy	(MEE-dee-a-stin-AHS-ko-pee) A procedure in which a tube is inserted into the chest to view the organs in the area between the lungs and nearby lymph nodes. The tube is inserted through an incision above the breastbone. This procedure is usually performed to get a tissue sample from the lymph nodes on the right side of the chest.
C16830	Medical_Device	Diagnostic_Therapeutic_and_Research_Equipment	Medical Device|Medical Devices	Medical device - any machinery designed to aid diagnostic and medical therapies. Medical device has to be designed with rigorous safety standards. There are several basic types of medical devices: life support equipment used to maintain a patient's body functions; therapeutic equipment; monitors and detectors to measure the indexes of a patient's state; imagine machines and laboratory equipment used with diagnostic and status monitoring purposes. In insurance parlance, the term is usually synonymous with assistive device, although it may include medical supplies.
C16831	Medical_Imaging	Imaging_Technique	Medical Imaging|imaging	In medicine, any technology which helps in visualization of any biological process, cell, tissue or organ for the screening, diagnosis, surgical procedure or therapy.
C16832	Medical_Oncology	Oncology	Medical Oncology|Oncology, Medical	The study and treatment of cancers with chemicals, biological products or immunotherapy.
C16833	Medicine	Medical_Science	Medicine	The branches of medical science that deal with nonsurgical techniques.
C16834	Meiosis	Nuclear_Division	Meiosis	A special form of cell division in which each daughter cell receives half the amount of DNA as the parent cell. Meiosis occurs during formation of egg and sperm cells in mammals.
C16835	Experimental_Malignant_Melanoma	Mouse_Neoplasms	Experimental Malignant Melanoma|Experimental Melanoma
C16836	Membrane_Metalloendopeptidase	Metalloproteinase	Membrane Metalloendopeptidase|CD10|Common ALL Antigen|Common Acute Lymphoblastic Leukemia Antigen|Enkephalinase|MME|NEP|Neprilysin|Neutral Endopeptidase|cALLa	A cell-surface enzyme found on prostate epithelial cells.  It can inhibit cell migration of prostate cancer cells, probably by disrupting focal adhesion kinase phosphorylation. (from J Clin Invest 2000;106:1399-1407 via Medscape)
C16837	Membrane_Protein	Protein_Organized_by_Location	Membrane Protein	Proteins that are physically associated with the membrane. This class of proteins resides in cellular or intracellular membranes. The physical association of each protein is divided into two classes: integral and peripheral.
C16838	Menstrual_Cycle	Reproductive_System_Process	Menstrual Cycle|MENCYC|menstrual cycle	(MEN-stroo-al) The monthly cycle of hormonal changes from the beginning of one menstrual period to the beginning of the next.
C16839	Psychological_Health	Health_Status	Psychological Health	for thorough searching see RTs.
C16840	Mental_Process	Neurologic_Process	Mental Process	Conceptual functions or thinking in all its forms. (NCI)
C16841	Detoxification	Detoxification_Process	Detoxification|Metabolism of Toxic Agents	Reduction of pharmacologic activity or toxicity of a drug or other foreign substance by a living system, usually by enzymatic action. It includes those metabolic transformations that make the substance more soluble for faster renal excretion.
C16842	Metabolism_Organismal	Retired_Concepts	Metabolism, Organismal|Intermediary Metabolism|Metabolism
C16843	Metalloproteinase	Protease	Metalloproteinase|METALLOPROTEASE	Encoded by Metalloproteinase Genes, Metalloproteinases (endopeptidases) use a metal ion, normally zinc, in the catalytic process and preferentially cleave the Gln-Gly peptide bond. Metalloproteinases inactivated by metal chelators. (NCI)
C16844	Metalloprotein	Protein_Organized_by_Structure	Metalloprotein	Proteins that include a metal ion as part of their structure or they contain a metal cofactor. The metal ion can be an isolated ion or coordinated with a nonprotein organic compound, such as the porphyrin moiety found in hemoproteins. Additionally, the metal can be co-coordinated with both a side chain of the protein and an inorganic nonmetallic ion.
C16845	Metallothionein	Trace_Metal_Storage_Protein	Metallothionein	Enzymes that use cysteine residues to transport metals such as copper and zinc throughout the body. The native polypeptide is found in abundant levels in the kidney cortex and liver.
C16846	Metaphase	M-Phase_Substage	Metaphase|Mitotic Metaphase	Arrangement of chromosomes in the equatorial plane of the central spindle to form the monaster.  Chromosomes separate into exactly similar halves. (NCI)
C16847	Techniques	root_node	Techniques|METH|Method|Methods|Methods and Techniques|Methods, Other|Technical|Technique	A practiced and regimented skill or series of actions.
C16848	Methylation	Biochemical_Reaction	Methylation	The covalent chemical or biochemical addition of a methyl group(s) to a compound. (NCI)
C16849	Methyltransferase	Transferase	Methyltransferase|EC 2.1.1	A class of enzymes that transfers a functional methyl group from one chemical compound to another.
C16850	Mexico	Country	Mexico|484|MEX|MX	A country in Central America, bordering the Caribbean Sea and the Gulf of Mexico, between Belize and the US and bordering the North Pacific Ocean, between Guatemala and the US. (CIA World Factbook 2002)
C16851	Microbiology	Biology	Microbiology	The science that deals with the study of microorganisms, including algae, archaea, bacteria, fungi, protozoa, and viruses.
C16852	Microfilament_Protein	Cytoskeletal_Protein	Microfilament Protein	Structurally complex proteins that are comprised of microfilaments, which are necessary components of the cellular cytoskeleton for motility and shape. Microfilaments physically associate with microtubules to play a structural role in cytoskeleton integrity.
C16853	Microscopy	Imaging_Technique	Microscopy	The application of microscope magnification to the study of materials that cannot be properly seen by the unaided eye.
C16854	Electron_Microscopy	Microscopy	Electron Microscopy	Any form of microscopy in which the interactions of electrons with the specimens are used to provide information about the final structure of that specimen. (from On-line Medical Dictionary)
C16855	Scanning_Electron_Microscopy	Electron_Microscopy	Scanning Electron Microscopy|Microscopy, Electron, Scanning	Technique of electron microscopy in which the specimen is coated with heavy metal and then scanned by an electron beam. The resolution is not as great as with transmission electron microscopy, but preparation is easier (often by fixation followed by critical point drying), the depth of focus is relatively enormous, the surface of a specimen can be seen (though not the interior unless the specimen is cracked open) and the image is aesthetically pleasing. (from On-line Medical Dictionary)
C16856	Fluorescence_Microscopy	Light_Microscopy	Fluorescence Microscopy|Fluorescence Light Microscopy|Microscopy, Light, Fluorescence	Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light (From MSH 2001).
C16857	Phase-Contrast_Microscopy	Light_Microscopy	Phase-Contrast Microscopy|Microscopy, Phase-Contrast	A simple non-quantitative form of interference microscopy of great utility in visualising live cells. Small differences in optical path length due to differences in refractive index and thickness of structures are visualised as differences in light intensity. (On-line Medical Dictionary)
C16858	Polarization_Microscopy	Light_Microscopy	Polarization Microscopy|Microscopy, Polarized Light	Any form of microscopy capable of detecting birefringent objects. Usually performed with a polarizing element below the stage to produce plane polarized light and an analyzer that is set to give total extinction of the background and thus to detect any birefringence.
C16859	Ultraviolet_Microscopy	Light_Microscopy	Ultraviolet Microscopy|Microscopy, Ultraviolet	The study and photographing of microscope specimens in ultraviolet light. It is particularly useful when all parts of the specimen viewed are equally transparent in the visible region. (The Photonics Dictionary)
C16860	Microsomal_Epoxide_Hydrolase	Hydrolase	Microsomal Epoxide Hydrolase|EC 3.3.2.3|EPHX1|Epoxide Hydratase|Epoxide Hydrolase 1|Epoxide Hydroxylase 1, Microsomal|Epoxide Hydroxylase 1, Microsomal (Xenobiotic)|mEH	Expression of microsomal epoxide hydrolase (mEH), a carcinogen-activating enzyme, in primary breast tumors may predict poor response to tamoxifen treatment. (from J Clin Oncol 2001;19:3-9 via Medscape)
C16861	Microtubule_Associated_Protein	Cytoskeletal_Protein	Microtubule Associated Protein|MAPs|Microtubule-Associated Proteins	Proteins associated with the microtubule assembly infrastructure.  These proteins include specialized motor proteins (dynein and kinesin) and smaller tubulin-crosslinking proteins (tau proteins). The proteins are required for both microtubule assembly and stabilization.
C16862	Microwave_Radiation	Nonionizing_Radiation	Microwave Radiation|Electromagnetic, Microwave|Radiation, Microwave	Electromagnetic radiation between the ultrahigh frequency radio and infrared (in the 10e-3 (micro) to about 0.5 X 10e-1 meter) region of the spectrum.
C16863	Minority_Group	Population_Group	Minority Group|Ethnic and Racial Minorities|Minorities|Minority	A minority is a group that is outnumbered by persons who do not belong to it, often people with different nationality, religion, culture or lifestyle from that of the mainstream in the society; racial or ethnic groups officially recognized by the U.S. government as minority populations.
C16864	Mitosis	Nuclear_Division	Mitosis|mitosis	The division of the eukaryotic cell nucleus to produce two daughter nuclei that, usually, contain the identical chromosome complement to their mother. (GO)
C16865	Mixed_Function_Oxidase	Oxidoreductase	Mixed Function Oxidase|Mixed Function Oxygenase	These enzymes use molecular oxygen catalyze the donation of one oxygen atom to a substrate specific site, while the other atom is donated to the generation of water. The enzyme uses molecular oxygen as the oxygen source instead of water, and is critical for several endocrine function operations.
C16866	Model_System	Cancer_Science	Model System|Biological Models|Model|Modeling System|Models	A representation of something, often idealized or modified to make it conceptually easier to understand.
C16867	Molecular_Model	Model_System	Molecular Model	Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
C16868	Neurological_Model	Model_System	Neurological Model	Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
C16869	Statistical_Modeling	Computer_Modeling	Statistical Modeling	Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
C16870	Mathematical_Model	Model_System	Mathematical Model|Math Models	Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena.
C16871	Moldova	Country	Moldova|498|MD|MDA|Republic of Moldova	A country in Eastern Europe, northeast of Romania. (CIA World Factbook 2002)
C16872	Molecular_Biology	Biology	Molecular Biology|DNA Molecular Biology	Molecular biology is the study of biology at a molecular level. It chiefly concerns itself with understanding the interactions between the various systems of a cell, including the interrelationship of DNA, RNA and protein synthesis and learning how these interactions are regulated. The field overlaps with other areas of biology, particularly genetics and biochemistry. (from Wikipedia)
C16873	Molecular_Neurobiology	Neurosciences	Molecular Neurobiology
C16874	Monaco	Country	Monaco|492|MC|MCO|MN	A country in Western Europe, bordering the Mediterranean Sea on the southern coast of France, near the border with Italy. (CIA World Factbook 2002)
C16875	Mongolia	Country	Mongolia|496|MG|MN|MNG	A country in Northern Asia, between China and Russia. (CIA World Factbook 2002)
C16876	Montserrat	Country	Montserrat|500|MH|MS|MSR	A country in the Caribbean, occupying an island in the Caribbean Sea, southeast of Puerto Rico. (CIA World Factbook 2002)
C16877	Morbidity	Vital_Statistics	Morbidity|morbidity	A disease or the incidence of disease within a population. Morbidity also refers to adverse effects caused by a treatment.
C16878	Morocco	Country	Morocco|504|MA|MAR|MO	A country in Northern Africa, bordering the North Atlantic Ocean and the Mediterranean Sea, between Algeria and Western Sahara. (CIA World Factbook 2002)
C16879	Morphogenesis	Developmental_Process	Morphogenesis	The process of shape formation: the processes that are responsible for producing the complex shapes of adults from the simple ball of cells that derives from division of the fertilized egg. (On-line Medical Dictionary)
C16880	Mortality	Vital_Statistics	Mortality	the ratio of deaths in an area to the population of that area; expressed per 1000 per year.
C16881	MOS_Gene	Serine-Threonine_Protein_Kinase_Gene	MOS Gene|MOS|MSV|v-MOS Moloney Murine Sarcoma Viral Oncogene Homolog Gene	The mos proto-oncogene-encoded serine/threonine protein kinase plays a key cell cycle-regulatory role during meiosis. The Mos protein is required for the activation and stabilisation of M phase-promoting factor MPF. As a component of a large multiprotein complex known as the cytostatic factor (CSF), Mos is involved in causing metaphase II arrest of eggs in vertebrates. Upon expression in somatic cells, Mos causes cell cycle perturbations resulting in cytotoxicity and neoplastic transformation. All the known biological activities of Mos are mediated through activation of the mitogen activated protein (MAP) kinase pathway. (from Prog Cell Cycle Res. 1997;3:251-9)
C16882	Mozambique	Country	Mozambique|508|MOZ|MZ	A country in Southern Africa, bordering the Mozambique Channel, between South Africa and Tanzania. (CIA World Factbook 2002)
C16883	Mucin	Glycoprotein	Mucin|Mucus Glycoprotein	An albuminoid substance which is contained in mucus, and gives to the latter secretion its peculiar ropy character. It is found in all the secretions from mucous glands, and also between the fibres of connective tissue, as in tendons. (On-line Medical Dictionary)
C16884	Muscle_Protein	Protein_Organized_by_Location	Muscle Protein	A special subset of proteins whose roles are directly related to the function of muscle cells. This group is comprised of both short and long filament polypeptides that are primarily involved in movement and muscle contraction and extension. Muscle proteins are also responsible for the conversion of chemical energy into mechanical energy.
C16885	Mutation	DNA_Sequence_Alteration	Mutation|Genetic Alteration|Genetic Change|mutation	Any change in the DNA of a cell.  Mutations may be caused by mistakes during cell division, or they may be caused by exposure to DNA-damaging agents in the environment.  Mutations can be harmful, beneficial, or have no effect.  If they occur in cells that make eggs or sperm, they can be inherited; if mutations occur in other types of cells, they are not inherited.  Certain mutations may lead to cancer or other diseases.
C16886	Oncogene_MYB	MYB_Gene	Oncogene MYB|Avian Myeloblastosis Viral (v-MYB) Oncogene Homolog|MYB|Oncogene AMV|v-MYB Avian Myeloblastosis Viral Oncogene Homolog	Human Oncogene MYB is a mutated variant of MYB Gene, which encodes 6 alternative isoforms of 640 aa 72-kDa nuclear c-MYB protein, a DNA-binding transcriptional activator critical for hematopoietic progenitor cell proliferation and differentiation. MYB contains 3 N-terminal MYB-like DNA-binding domains that specifically recognize YAAC[GT]G, a central transcriptional activation domain and a C-terminal transcriptional repression domain. MYB may interact with HIPK2 and NLK; phosphorylation by NLK on multiple sites may induce proteasomal degradation. Ubiquitination may be mediated by SIAH1. Oncogene MYB disrupts normal cell function.
C16887	MYC_Gene	MYC_Family_Gene	MYC Gene|C-MYC|v-MYC Myelocytomatosis Viral Oncogene Homolog (Avian) Gene|v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog	Human MYC Gene at 8q24.12-q24.13 encodes c-MYC Protein, a leucine zipper DNA-binding transcription factor involved in cellular responses to growth factors that recognizes CAC(GA)TG sequence. AP2 suppresses MYC expression while beta-catenin bound to TCF4, activates MYC transcription through TCF4 promoter sites. The RAS/RAF/MAPK pathway promotes MYC accumulation by stabilizing MYC protein. Absent mitogenic signals, MYC has a short half-life due to 26S proteasomal degradation. DNA binding requires dimerization with a bHLH protein, such as MAX. MYC activates growth-promoting genes, such as ODC1 and CDC25A, and represses growth arrest gene GAS1 via the MYC BOX2. TERT is activated by MYC-induced expression. MYC also activates E2F genes and S phase requires MYC-induced E2F2 or E2F3. MYC interacts with TGF-beta growth inhibitory signal transducers SMAD2 and SMAD3 to block transcription. (from SWISS-PROT, OMIM, and NCI)
C16888	Myelogram	Medical_Image	Myelogram|myelogram	(MY-eh-lo-gram) An x-ray of the spinal cord after an injection of dye into the space between the lining of the spinal cord and brain.
C16889	Oncogene_N-RAS	NRAS_Gene	Oncogene N-RAS|NRAS|NRAS1|Neuroblastoma RAS Viral Oncogene Homolog	Human Oncogene N-RAS is a mutated variant of NRAS Gene (RAS Family), which encodes p21 N-Ras Protein, a monomeric GTPase involved in transmembrane signal transduction that alternates between inactive GDP-bound and active GTP-bound forms. RAS is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein. Mitogen-stimulated RAS stabilizes MYC protein and enhances MYC accumulation by the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC. Implicated in a variety of human tumors, specific amino acid mutations activate c-RAS and transform cells. Oncogene NRAS disrupts normal cell function.
C16890	Cytochrome-P450_Reductase	Oxidoreductase	Cytochrome P450 Reductase|EC 1.6.2.4|NADPH-Cytochrome P450 Reductase|NADPH-Specific Cytochrome C Reductase|POR	A flavoprotein that catalyzes the reduction of heme-thiolate-dependent monooxygenases and is part of the microsomal hydroxylating system. Its physiological acceptor is probably cytochrome P-450. EC 1.6.2.4.
C16891	Namibia	Country	Namibia|516|NA|NAM|WA	A country in Southern Africa, bordering the South Atlantic Ocean, between Angola and South Africa. (CIA World Factbook 2002)
C16892	National_Academy_of_Science	Other_Agency_or_Organization	National Academy of Science
C16893	National_Center_for_Health_Statistics	Other_Agency_or_Organization	National Center for Health Statistics|NCHS	A part of the Centers for Disease Control and Prevention, the NCHS is the primary Federal organization responsible for the collection, analyses, and dissemination of health statistics.
C16894	National_Institute_of_Mental_Health	Component_of_the_National_Institutes_of_Health	National Institute of Mental Health|NIMH
C16895	National_Institutes_of_Health	Component_of_NCI_Governance	National Institutes of Health|NIH	NIH.  The National Institutes of Health, the focal point of biomedical research in the United States, conducts research in its own laboratories; supports the research of non-Federal scientists in universities, medical schools, hospitals, and research institutions throughout the country and abroad; helps in the training of research investigators; and fosters communication of medical information.  Access the NIH Web site at http://www.nih.gov.
C16896	Nauru	Country	Nauru|520|NR|NRU	A country in Oceania, occupying an island in the South Pacific Ocean, south of the Marshall Islands. (CIA World Factbook 2002)
C16897	Necrosis	Cell_Death	Necrosis|NECR|necrosis	(ne-KRO-sis) Refers to the death of living tissues.
C16898	NEF_Protein	Viral_Protein	NEF Protein	An integral component of HIV-1 particles. Nef facilitates a step in the viral life cycle occurring between penetration and reverse transcription (Aiken. Virology 1998; 248:139-147)
C16899	Stage	Tumor_Pathology	Stage|ST|T-Stage|Tumor Stage|stage	The extent of a cancer within the body, especially whether the disease has spread from the original site to other parts of the body.
C16900	Neovascularization	Pathologic_Process	Neovascularization|Neovascularization, Pathologic|Vascularization	Growth of new blood vessels feeding a tissue, as with a tumor.
C16901	Nepal	Country	Nepal|524|NP|NPL	A country in Southern Asia, between China and India. (CIA World Factbook 2002)
C16902	Nephrology	Internal_Medicine	Nephrology
C16903	Netherlands	Country	Netherlands|528|NL|NLD	A country in Western Europe, bordering the North Sea, between Belgium and Germany. (CIA World Factbook 2002)
C16904	Netherlands_Antilles	Country	Netherlands Antilles|530|AN|ANT|NT	A country in the Caribbean, comprising two island groups in the Caribbean Sea - one includes Curacao and Bonaire north of Venezuela; the other is east of the Virgin Islands. (CIA World Factbook 2002)
C16905	Neuroanatomy	Anatomical_Sciences|Neurosciences	Neuroanatomy
C16906	Neurochemistry	Neurosciences	Neurochemistry
C16907	Neuroendocrinology	Endocrinology|Neurosciences	Neuroendocrinology
C16908	Neurology	Medical_Specialty	Neurology	the branch of medical science that deals with the study of structure, function, and diseases of the nervous system; for thorough searching also see NEUROSCIENCE, MENTAL DISORDER, NERVOUS SYSTEM DISORDER, NERVOUS SYSTEM DISORDER DIAGNOSIS, MENTAL DISORDER DIAGNOSIS, NERVOUS SYSTEM DISORDER CHEMOTHERAPY, COMMUNICATION DISORDER, NEUROMUSCULAR DISORDER.
C16909	Neuropharmacology	Neuropharmacology_and_Toxicology	Neuropharmacology
C16910	Neurophysiology	Neurosciences|Physiology	Neurophysiology
C16911	Neuropsychology	Neurosciences	Neuropsychology	study of the relationships between behavior, experience, and neurophysiological processes.
C16912	Neurosciences	Biological_Sciences	Neurosciences
C16913	New_Caledonia	Country	New Caledonia|540|NC|NCL	A country in the Pacific, comprised of islands in the South Pacific Ocean, east of Australia. (CIA World Factbook 2002)
C16914	New_Zealand	Country	New Zealand|554|NZ|NZL	A country in the Pacific, comprised of islands in the South Pacific Ocean, southeast of Australia. (CIA World Factbook 2002)
C16915	Nicaragua	Country	Nicaragua|558|NI|NIC|NU	A country in Central America, bordering both the Caribbean Sea and the North Pacific Ocean, between Costa Rica and Honduras. (CIA World Factbook 2002)
C16916	Niger	Country	Niger|562|NE|NER|NG	A country in Western Africa, southeast of Algeria. (CIA World Factbook 2002)
C16917	Nigeria	Country	Nigeria|566|NG|NGA|NI	A country in Western Africa, bordering the Gulf of Guinea, between Benin and Cameroon. (CIA World Factbook 2002)
C16918	Niue	Country	Niue|570|NE|NIU|NU	A country in the Pacific, occupying an island in the South Pacific Ocean, east of Tonga. (CIA World Factbook 2002)
C16919	Norfolk_Island	Country	Norfolk Island|574|NF|NFK	A country in the Pacific, occupying an island in the South Pacific Ocean, east of Australia. (CIA World Factbook 2002)
C16920	Norway	Country	Norway|578|NO|NOR	A country in Northern Europe, bordering the North Sea and the North Atlantic Ocean, west of Sweden. (CIA World Factbook 2002)
C16921	Nuclear_Magnetic_Resonance	Physical_Phenomena_or_Properties	Nuclear Magnetic Resonance|Magnetic Resonance|NMR	Nuclear magnetic resonance (NMR) is a physical phenomenon involving the interaction of atomic nuclei placed in an external magnetic field with an applied electromagnetic field oscillating at a particular frequency. Magnetic conditions within the material are measured by monitoring the radiation absorbed and emitted by the atomic nuclei. It is the underlying principle of Magnetic Resonance Imaging (MRI). (from Wikipedia)
C16922	Nuclear_Medicine	Radiology	Nuclear Medicine|Radiology / Radiation Biology / Nuclear Medicine|Radiology-Nuclear Medicine	Nuclear Medicine is the branch of medicine that uses radioactive materials either to image a patient's body or to destroy diseased cells.
C16923	Nuclear_Protein	Protein_Organized_by_Location	Nuclear Protein	Proteins that are localized to the nucleus of the cell. These proteins are involved in a variety of cellular regulation functions including transport, gene expression, and cell signaling.
C16924	Nucleic_Acid_Hybridization	Molecular_Biology_Techniques	Nucleic Acid Hybridization|Hybridization|Molecular Biology, Molecular Hybridization	Technique in which single stranded nucleic acids are allowed to interact so that complexes, or hybrids, are formed by molecules with sufficiently similar, complementary sequences. By this means the degree of sequence identity can be assessed and specific sequences detected. (From Biology-online)
C16925	Nucleotidyltransferase	Phosphotransferase	Nucleotidyltransferase|EC 2.7.7	nucleotidyltransferases. Enzymes (EC class 2.7.7) transferring nucleotide residues (nucleotidyls) from nucleoside di- or triphosphates into dimer or polymer forms. Some nucleotidyltransferases bear specific names (e.g., adenylyltransferases), or trivial names indicating the linkage hydrolyzed in the synthesis (pyrophosphorylases, phosphorylases), or names of the material synthesized (RNA or DNA polymerase).
C16926	Nursing	Health_Sciences	Nursing|Discipline of Nursing|Nursing Field|Nursing Profession	Nursing encompasses autonomous and collaborative care of individuals of all ages, families, groups and communities, sick or well and in all settings. Nursing includes the promotion of health, prevention of illness, and the care of ill, disabled and dying people. Advocacy, promotion of a safe environment, research, participation in shaping health policy and in patient and health systems management, and education are also key nursing roles. (ICN 2002)
C16927	Nutritional_Science	Health_Sciences	Nutritional Science|Nutrition	The science of food, the nutrients and other substances contained therein, their action, interaction, and balance in relation to health and disease.
C16928	Obstetrics	Medical_Specialty|Surgical_Specialty	Obstetrics	Obstetrics is the surgical specialty dealing with the care of a woman and her offspring during pregnancy, childbirth and the puerperium (the period shortly after birth). (Wikipedia)
C16929	Occupational_Exposure	Environmental_and_Occupational_Exposure	Occupational Exposure	The exposure to potentially harmful agents that occurs as a result of one's occupation.
C16930	Occupational_Health_Nursing	Public_Health_Nursing	Occupational Health Nursing
C16931	Occupational_Medicine	Medical_Specialty	Occupational Medicine|Occupational or Industrial Medicine	This branch of medicine is concerned with the prevention, diagnosis, and treatment of injuries and illnesses that occur at the workplace or as a result of toxic exposures, stress, or accidents at the workplace. Occupational medicine encompasses issues such as industrial hygiene, safety, pollution control, ergonomics, industrial and agricultural toxicology, disability evaluation, physical rehabilitation, industrial psychology and emergency medicine. (BioTech Life Science Dictionary)
C16932	Odds_Ratio	Risk_Estimate	Odds Ratio
C16933	Oman	Country	Oman|512|MU|OM|OMN	A country in the Middle East, bordering the Arabian Sea, Gulf of Oman, and Persian Gulf, between Yemen and UAE. (CIA World Factbook 2002)
C16934	Oncoprotein	Protein_Organized_by_Function	Oncoprotein	A general term referring to the gene product of an oncogene. (http://www.copewithcytokines.de/cope.cgi?7308)
C16935	Viral_Oncogene_Protein	Oncoprotein|Viral_Protein	Viral Oncogene Protein	Proteins expressed by virally mutated genes that once played a normal role in the cell as a proto-oncogene. There are several different types of viral oncogene proteins, and the expression of these proteins contributes to a transformed phenotype in cells.
C16936	Oncogene	Cancer_Gene	Oncogene|Cancer-Promoting Gene|oncogene	A gene that normally directs cell growth. If altered, an oncogene can promote or allow the uncontrolled growth of cancer. Alterations can be inherited or caused by an environmental exposure to carcinogens.
C16937	Oncology_Nursing	Nursing	Oncology Nursing|Oncologic Nursing|Oncological Nursing
C16938	Oogenesis	Gametogenesis	Oogenesis	The development of ovum, which are the female germ cells. Oogenesis occurs by meiosis and is essential for the production of mature eggs.
C16939	Ophthalmology	Medical_Specialty|Surgical_Specialty	Ophthalmology
C16940	Optics	Physics	Optics	Optics is the branch of physics that describes the behavior and properties of light and the interaction of light with matter. (from Wikipedia)
C16941	Organ_Culture	Tissue_Culture	Organ Culture|Culturing, in vitro Organ|Culturing, in vitro Vertebrate, Organ	The maintenance or growth of tissues, organ primordia, or the parts or whole of an organ in vitro in such a way as to allow differentiation or preservation of the architecture or function.
C16942	Orthopedics	Surgical_Specialty	Orthopedics|Orthopedic Surgery|Orthopedic Surgical Profession	Orthopedics is the branch of surgery broadly concerned with the skeletal system (bones and joints). (from On-line Medical Dictionary)
C16943	Otolaryngology	Medical_Specialty|Surgical_Specialty	Otolaryngology|Oto/Rhino/Laryngology|Otorhinolaryngology	Ear, nose, and throat medicine.
C16944	Oxidation	Biochemical_Reaction	Oxidation|oxidation	Process in which molecules are split to give products that have unpaired electrons.
C16945	Oxidation-Reduction	Biochemical_Reaction	Oxidation/Reduction|Oxidoreduction|Redox	All electron-transfer reactions are considered oxidation/reduction reactions. The substance gaining electrons ("oxidizing agent" or "oxidant") is oxidizing the substance that is losing electrons ("reducing agent" or "reductant"). In the process, the "oxidizing agent" is itself reduced by the "reducing agent." (from Electrochemistry Dictionary; http://electrochem.cwru.edu/ed/dict.htm)
C16946	Oxidoreductase	Enzyme	Oxidoreductase	The class of all enzymes catalyzing oxidoreduction reactions (EC class 1). The substrate that is oxidized is regarded as a hydrogen donor. The systematic name is based on donor: acceptor oxidoreductase. The recommended name will be dehydrogenase, wherever this is possible; as an alternative, reductase can be used. Oxidase is only used in cases where O2 is the acceptor. (Enzyme Nomenclature, 1992, p9)
C16947	Plasminogen_Activator_Inhibitor-1	Plasminogen_Activator_Inhibitor	Plasminogen Activator Inhibitor-1|Endothelial Plasminogen Activator Inhibitor|Nexin|PAI|PAI-1|PAI1|PLANH1|Plasminogen Activator Inhibitor Type 1|SERPINE1|Serine or Cysteine Proteinase Inhibitor Clade E Member 1	Likely expressed primarily in vascular endothelia by single copy human SERPINE1 Gene (Serpin Family), 402-aa 45-kDa (nonglycosylated, predicted) secreted plasma Plasminogen Activator Inhibitor 1 is an acid-stable glycoprotein in plasma, platelets, and endothelia with structural similarity to angiotensinogen, alpha-1-antitrypsin, and antithrombin III. PAI-1 acts as bait for tissue plasminogen activator, urokinase, and protein C; rapid interaction with TPA may regulate fibrinolysis. SERPINE1 defects cause of PAI-1 deficiency. (NCI)
C16948	Plasminogen_Activator_Inhibitor-2	Plasminogen_Activator_Inhibitor	Plasminogen Activator Inhibitor-2|Arginine-Serpin|Monocyte Arg-Serpin|PAI|PAI-2|PLANH2|Placental Plasminogen Activator Inhibitor|Plasminogen Activator Inhibitor Type II|SERPINB2|Serine or Cysteine Proteinase Inhibitor Clade B Member 2|Urokinase Inhibitor	Expressed in keratinocytes, monocytes, macrophages, placenta, and trophoblast by human SERPINB2 Gene (Serpin Family), 415-aa 47-kDa (predicted, unglycosylated) cytoplasmic Plasminogen Activator Inhibitor 2 is a specific inhibitor of urokinase-type plasminogen activator thought to regulate plasminogen activation in the extravascular compartment and to have a possible role in placental maintenance or embryo development. The primary intracellular distribution of SERPINB2 may also indicate a regulatory role in a protease-dependent cellular process such as apoptosis. (NCI)
C16949	Pakistan	Country	Pakistan|586|PAK|PK	A country in Southern Asia, bordering the Arabian Sea, between India on the east and Iran and Afghanistan on the west and China in the north. (CIA World Factbook 2002)
C16950	Palpation	Physical_Examination	Palpation|PALP|palpation	Examination by pressing on the surface of the body to feel the organs or tissues underneath.
C16951	Panama	Country	Panama|591|PA|PAN|PM	A country in Central America, bordering both the Caribbean Sea and the North Pacific Ocean, between Colombia and Costa Rica. (CIA World Factbook 2002)
C16952	Papua_New_Guinea	Country	Papua New Guinea|598|PG|PNG|PP	A country in Southeastern Asia, comprising a group of islands and including the eastern half of the island of New Guinea, between the Coral Sea and the South Pacific Ocean, east of Indonesia. (CIA World Factbook 2002)
C16953	Paraguay	Country	Paraguay|600|PA|PRY|PY	A country in Central South America, northeast of Argentina. (CIA World Factbook 2002)
C16954	Parasitology	Internal_Medicine	Parasitology|Microbiology, Virology, Parasitology	A branch of biology which deals with parasitic organisms with a strong emphasis on their role in disease.
C16955	Parity	Personal_Attribute	Parity	The number of live-born children a woman has delivered.
C16956	Pathologic_Process	Biological_Process	Pathologic Process	A biologic function or a process having an abnormal or deleterious effect at the subcellular, cellular, multicellular, or organismal level. (NCI)
C16957	Oral_Pathology	Dentistry|Pathology	Oral Pathology
C16958	Surgical_Pathology	Pathology	Surgical Pathology	A field of anatomical pathology in which tissue or cells removed from a living organism are macroscopically and microscopically reviewed for the purpose of disease diagnosis.
C16959	Patient_Education	Patient_or_Public_Education	Patient Education
C16960	Patient	Population_Group	Patient|PT|Patients	A person who receives medical attention, care, or treatment, or who is registered with medical professional or institution with the purpose to receive medical care when necessary.
C16961	Pattern_Recognition	Computational_Technique	Pattern Recognition|Pattern Recognition/Display/Analysis	A branch of artificial intelligence concerned with the identification of visual or audio patterns by computers.For the computer to recognize the patterns, the patterns must be converted into digital signals and compared with patterns already stored in memory.Some uses of this technology are in character recognition, voice recognition, handwriting recognition, and robotics. (High-Tech Dictionary)
C16962	Pediatrics	Medical_Specialty	Pediatrics	The branch of medicine concerned with the treatment of infants and children.
C16963	Peer_Review	Grant_Review_Process	Peer Review	Peer review is a scholarly process that subjects an author's work or ideas to the scrutiny of one or more others who are experts in the field. These referees each return an evaluation of the work, including suggestions for improvement. Evaluations usually include an explicit recommendation of what to do with the manuscript or proposal. A chief rationale for peer review is that rarely is just one person, or one closely working group, able to spot every mistake or weakness in a complicated piece of work. This is not necessarily because these deficiencies represent needles in a haystack, but because in a new and creative and perhaps eclectic intellectual product, any one of these opportunities for improvement may stand out only to someone with a particular expertise and/or history of experience. Therefore showing a work to various others increases the probability that the weakness will be identified and fixed. (from Wikipedia)
C16964	Beta-Lactamase	Bacterial_Protein	Beta-Lactamase|Cephalosporinase|Penicillinase	An enzyme that brings about the hydrolysis of a beta-lactam (as penicillin to penicilloic acid); found in most staphylococcus strains that are naturally resistant to penicillin.
C16965	Protease	Hydrolase	Protease|Peptidase|Proteases|Proteinase|Proteolytic Enzyme	Enzymes acting on peptide bonds. EC 3.4.-
C16966	Peptide_Synthesis	Molecular_Biology_Techniques	Peptide Synthesis	The sequential formation of peptide bonds between amino acids
C16967	Perception	Mental_Process	Perception	the process of producing an internal, conscious image through stimulating a sensory system; it involves the recognition that stimulation has occurred, and the ability to discriminate various aspects of the stimulus.
C16968	Peristalsis	Gastrointestinal_Process	Peristalsis|peristalsis	(pair-ih-STAL-sis) The rippling motion of muscles in the intestine or other tubular organs characterized by the alternate contraction and relaxation of the muscles that propel the contents onward.
C16969	Laparoscopy	Endoscopy	Laparoscopy|Diagnostic Laparoscopy|laparoscopy	(lap-a-RAHS-ko-pee) The insertion of a thin, lighted tube (called a laparoscope) through the abdominal wall to inspect the inside of the abdomen and remove tissue samples.
C16970	Permease	Transport_Protein	Permease	An extensive group of membrane proteins that function as channels to transport specific molecules in or out of the cell. The enzymatic activity results in the increased permeability of cellular membranes.
C16971	Permissiveness_Behavior	Personal_Behavior	Permissiveness, Behavior
C16972	Peru	Country	Peru|604|PE|PER	A country in Western South America, bordering the South Pacific Ocean, between Chile and Ecuador. (CIA World Factbook 2002)
C16973	Pharmacogenetics	Genetics	Pharmacogenetics	Pharmacogenetics is broadly defined as the effect of inheritance on individual variations in response to drugs and xenobiotics. These variations may involve individual differences in therapeutic efficacy or adverse drug reactions. (from Medscape)
C16974	Pharmacology	Biological_Sciences	Pharmacology	Pharmacology is the study of drugs in all their aspects. It is concerned with the art and science of the preparation, compounding, and dispensing of drugs. (Pharmacology Glossary; http://www.bumc.bu.edu)
C16975	Clinical_Pharmacology	Pharmacology	Clinical Pharmacology
C16976	Pharmaceutics	Pharmacology	Pharmaceutics|Pharmacy
C16977	Phenotype	Miscellaneous_Molecular_Biology_Terms	Phenotype	The assemblage of traits or outward appearance of an individual. It is the product of interactions between genes and between genes and the environment.
C16978	Philippines	Country	Philippines|608|PH|PHL|RP	A country in Southeastern Asia, comprised of an archipelago between the Philippine Sea and the South China Sea, east of Vietnam. (CIA World Factbook 2002)
C16979	Phospholipase-A2	Phospholipase	Phospholipase A2|EC 3.1.1.4|PLA2	Various types of calcium-dependent or -independent Phospholipases A2 hydrolyze phospholipids. Group I, II, and III phospholipases are secreted, while group IV phospholipases are cytosolic. The best characterized phospholipases are group II. (NCI)
C16980	Phospholipase	Esterase	Phospholipase|Lecithinase|SY|NCI|	Enzymes that catalyze the cleavage of a phospholipid molecule by the addition of water, thereby causing hydrolysis. The classification is based on the specificity of the bond cleaved. Hydrolytic activity initiates signaling cascades in the cell.
C16981	Phosphatase	Hydrolase	Phosphatase
C16982	Phosphoprotein	Protein_Organized_by_Structure	Phosphoprotein	Proteins that contain phosphate groups esterified to serine, threonine or tyrosine. The phosphate group usually regulates protein function. (On-line Medical Dictionary)
C16983	Phosphorylation	Biochemical_Reaction	Phosphorylation	The creation of a phosphate derivative of an organic molecule. This is usually achieved by transferring a phosphate group from ATP via the action of a kinase.
C16984	Phosphotransferase	Transferase	Phosphotransferase|EC 2.7|Phosphotransferases	A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7.
C16985	Photochemistry	Physical_Chemistry	Photochemistry
C16986	Photosynthesis	Biosynthesis	Photosynthesis	The process through which light energy, water, and carbon dioxide are converted to carbohydrate and oxygen in the presence of chlorophyll. Occurs in plants, algae, cyanobacteria and lichens. (BioTech Life Science Dictionary)
C16987	Physical_Sciences	Occupation_or_Discipline	Physical Sciences	tree section heading for chemistry, physics, and related terms.
C16988	Physician_Office	Healthcare_Facility	Physician Office|Physician Offices
C16989	Physics	Physical_Sciences	Physics
C16990	Physiology	Biological_Sciences	Physiology	Physiology is the study of the mechanical, physical, and biochemical functions of living organisms. (from Wikipedia)
C16991	Comparative_Physiology	Comparative_Biology	Comparative Physiology
C16992	Physiologic_Process	Retired_Concepts	Physiologic Process
C16993	Pitcairn_Island	Country	Pitcairn Island|612|PC|PCN|PN|Pitcairn	A country in the Pacific, comprised of islands in the South Pacific Ocean, about midway between Peru and New Zealand. (CIA World Fact book 2002)
C16994	Plasminogen	Extracellular_Protein	Plasminogen|EC 3.4.21.7|PLG|PLMN	Plasminogen is a precursor of the potent serine protease plasmin and occurs at high concentrations in body fluids. Activation of plasminogen to the enzymatically active form plasmin is a proteolytic event and tightly controlled. A key feature in the formation and stability of plasmin activity is the attachment of plasminogen (and also of the formed plasmin) onto lysine-containing residues on target protein, such as fibrin. Plasmin cleaves fibrin clots and e.g. non-collagenous proteins of basement membranes and extracellular matrices, such as laminin and fibronectin. Plasmin also activates latent pro-collagenases and is thought to be crucial for the penetration of metastatic tumor cells into basement membranes.
C16995	Tissue_Plasminogen_Activator	Plasminogen_Activator	Tissue Plasminogen Activator|Activase|Alteplase|PLAT|Reteplase|T-Plasminogen Activator|TPA|Tissue-Type Plasminogen Activator|t-PA	A secreted serine protease which converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. Tissue-type plasminogen activator is synthesized as a single chain which is cleaved by plasmin to a two chain disulfide linked protein. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding; decreased activity leads to hypofibrinolysis which can result in thrombosis or embolism. (from LocusLink)
C16996	Plasminogen_Activator	Protease	Plasminogen Activator
C16997	Plasminogen_Activator_Inhibitor	Serpin	Plasminogen Activator Inhibitor	synthesized and secreted locally from vascular endothelial cells; primary physiologic inhibitor of tissue plasminogen activator; also inhibits urokinase; implicated in thrombotic and hemorrhagic disorders.
C16998	Platelet_Activating_Factor	Lipid	Platelet Activating Factor|1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine|PAF
C16999	Platelet_Aggregation	Multicellular_Process	Platelet Aggregation	The accumulation and adherence of platelets to form a clot or thrombus. When injury or bleeding occurs, platelets clump together at the site of injury; they expand and adhere to the injured area, thereby acting as a plug to reduce the bleeding. Platelet dysfunction can result in blood clotting and bleeding disorders.
C17000	Pleomorphism	Miscellaneous_Molecular_Biology_Terms	Pleomorphism	Having different forms at different stages of the life cycle.
C17001	Ploidy	Properties_or_Attributes	Ploidy|DI|DNA Content|DNA Index|DNA Ploidy|ploidy	(PLOY-dee) The number of sets of chromosomes in a cell or an organism.  For example, haploid means one set and diploid means two sets.
C17002	Poland	Country	Poland|616|PL|POL	A country in Central Europe, east of Germany. (CIA World Factbook 2002)
C17003	Polymerase_Chain_Reaction	Molecular_Biology_Techniques	Polymerase Chain Reaction|PCR|polymerase chain reaction	A laboratory method used to make many copies of a specific DNA sequence.
C17004	Genetic_Polymorphism	Genetic_Variation	Genetic Polymorphism|Polymorphism|polymorphism	A common variation or mutation in DNA.
C17005	Population_Group	Social_Concepts	Population Group|GP|Group|Population	A group of individuals united by a common factor (e.g., geographic location, ethnicity, disease, age, gender)
C17006	Portugal	Country	Portugal|620|PO|PRT|PT	A country in Southwestern Europe, bordering the North Atlantic Ocean, west of Spain. (CIA World Factbook 2002)
C17007	Positron_Emission_Tomography	Computed_Tomography	Positron Emission Tomography|Medical Imaging, Positron Emission Tomography|PET|PET Scan|PET scan|PETSCAN|Positron Emission Tomography Scan|Positron-Emission Tomography|positron emission tomography scan|proton magnetic resonance spectroscopic imaging	A computerized image of the metabolic activity of body tissues used to determine the presence of disease.
C17008	Potassium_Channel	Ion_Channel	Potassium Channel	Ion channel selective for potassium ions. There are several types, each with different functions. (On-line Medical Dictionary)
C17009	Poverty	Socioeconomic_Factors	Poverty	Poverty is a subjective and comparative term describing a lack of sufficient wealth (usually understood as capital, money, material goods, or resources especially natural resources) to live what is understood in a society as a "normal" life: for instance, to be capable of raising a healthy family, and especially educating children and participating in society. A person living in this condition of poverty is said to be poor. The meaning of "sufficient" varies widely across the different political and economic areas of the world. (from Wikipedia)
C17010	Prevalence	Vital_Statistics	Prevalence	the ratio (for a given time period) of the number of occurrences of a disease or event to the number of units at risk in the population.
C17011	Preventive_Medicine	Medical_Specialty	Preventive Medicine
C17012	Proctoscopy	Sigmoidoscopy	Proctoscopy|proctoscopy	(prok-TOS -ko-pee) An examination of the rectum using a thin, lighted tube called a proctoscope.
C17013	Prognosis	Conceptual_Entities	Prognosis|Prediction of Outcome = Prognosis|prognosis	(prog-NO-sis) The likely outcome or course of a disease; the chance of recovery or recurrence.
C17014	Prophase	M-Phase_Substage	Prophase|Mitotic Prophase	Formation of paired chromosomes; disappearance of nuclear membrane; appearance of the achromatic spindle; formation of polar bodies.  (NCI)
C17015	Cyclooxygenase	Oxygenase	Cyclooxygenase
C17016	Prosthodontics	Dentistry	Prosthodontics	The branch of dentistry dealing with the replacement of teeth and related mouth or jaw structures by artificial devices.
C17017	Protein_Kinase-C	Serine-Threonine_Protein_Kinase	Protein Kinase C|PKC
C17018	Protein_Kinase	Kinase	Protein Kinase|EC 2.7.1.37	group of enzymes under review by NC-IUBMB include EC 2.7.1.38, EC 2.7.1.70, EC 2.7.1.99, EC 2.7.1.109, EC 2.7.1.110, EC 2.7.1.111, EC 2.7.1.115, EC 2.7. 1.116, EC 2.7.1.124, EC 2.7.1.135, and EC 2.7.1.141.
C17019	Post-Translational_Modification	Biochemical_Reaction	Post-Translational Modification|Post Translational Modification|Protein Modification|Protein/Amino Acid Biochemistry, Post-Translational Modification	The enzymatic processing of a polypeptide chain after translation from messenger RNA and after peptide bond formation has occurred. Examples include glycosylation, acylation, limited proteolysis, phosphorylation, isoprenylation. (On-line Medical Dictionary)
C17020	Protein_Tyrosine_Kinase	Protein_Kinase	Protein Tyrosine Kinase|EC 2.7.1.112|PTK|Protein-Tyrosine Kinase|Tyrosine Kinase|Tyrosine Protein Kinase|Tyrosine-Specific Protein Kinase	Kinases that phosphorylate protein tyrosine residues. These kinases play major roles in mitogenic signalling, and can be divided into two subfamilies: receptor tyrosine kinases, that have an extracellular ligand-binding domain, a single transmembrane domain, and an intracellular tyrosine kinase domain; and nonreceptor tyrosine kinases, which are soluble, cytoplasmic kinases. (Dictionary of Cell and Molecular Biology Online)
C17021	Protein	Gene_Product	Protein|PR|Proteins	Proteins are a group of complex organic macromolecules composed of one or more chains (linear polymers) of alpha-L-amino acids linked by peptide bonds and ranging in size from a few thousand to over 1 million Daltons. Proteins are fundamental genetically encoded components of living cells with specific structures and functions dictated by amino acid sequence.
C17022	Proteoglycan	Glycoprotein	Proteoglycan|proteoglycan	A molecule that contains both protein and glycosaminoglycans, which are a type of polysaccharide.  Proteoglycans are found in cartilage and other connective tissues.
C17023	Proto-Oncogene	Gene	Proto-Oncogene|Cellular Oncogene|Cellular Oncogenes|c-ONC	Oncogenes are altered forms of normal cellular genes called proto-oncogene. Many proto-oncogenes are homologous to viral oncogenes and involved in the control of cell proliferation or differentiation. Mutations, amplifications or rearrangements of proto-oncogenes lead to upregulated or deregulated cell growth and allow them to function as oncogenes.
C17024	Proton	Subatomic_Particle	Proton|proton	A small, positively charged particle of matter found in the atoms of all elements.  Streams of protons generated by special equipment can be used for radiation treatment.
C17025	Psychiatric_Nursing	Nursing	Psychiatric Nursing|Psychiatric/Mental Health Nursing
C17026	Psychiatry	Medical_Specialty	Psychiatry	for thorough searching see RTs.
C17027	Psychology	Behavioral_Sciences	Psychology	study of mental and behavioral phenomena in individuals and groups; human and nonhuman species are included.
C17028	Clinical_Psychology	Psychology	Clinical Psychology
C17029	Comparative_Psychology	Psychology	Comparative Psychology
C17030	Educational_Psychology	Psychology	Educational Psychology
C17031	Experimental_Psychiatry	Psychiatry	Experimental Psychiatry	A subdiscipline of psychiatry that is concerned with the study of conditioning, learning, perception, motivation, emotion, language, and thinking; also used in relation to subject-matter areas in which experimental methods are emphasized.
C17032	Psychology_Industrial	Psychology	Industrial Psychology|Industrial/Organizational Psychology|Psychology, Industrial	The branch of applied psychology that is concerned with efficient management of an industrial labor force and especially with problems encountered by workers in a mechanized environment. (Bartleby.com)
C17033	Social_Psychology	Psychology	Social Psychology	The branch of psychology that studies persons and their relationships with others and with groups and with society as a whole.
C17034	Psychometrics	Psychology	Psychometrics	Psychometrics is the science of measuring "psychological" aspects of a person such as knowledge, skills, abilities, or personality. Measurement of these unobservable phenomena is difficult and much of the research and accumulated art of this discipline is designed to reliably define and then quantify. (from Wikipedia)
C17035	Psychopathology	Pathology	Psychopathology	the study of disorders of the psyche.
C17036	Psychopharmacology	Pharmacology	Psychopharmacology|Pharmacology-Psychopharmacology|Psychopharmacology / Toxicology	The science concerned with drug action and its effect on cognition and behavior
C17037	Psychophysiology	Physiology	Psychophysiology	branch of psychology which experimentally investigates the physiological basis of behavior, including anatomical structures, psychological processes, and mental functions.
C17038	Psychosomatic_Medicine	Psychiatry	Psychosomatic Medicine
C17039	Public_Health	Medical_Specialty	Public Health	The science and practice of protecting and improving the health of a community, as by preventive medicine, health education, control of communicable diseases, application of sanitary measures, and monitoring of environmental hazards. (Disability History Museum glossary; http://www.disabilitymuseum.org/glossary.php)
C17040	Public_Health_Nursing	Nursing	Public Health Nursing|Public Health/Community Health/Occupational Health Nursing
C17041	Public_Policy	Policy	Public Policy	The basic policy or set of policies forming the foundation of public laws, especially such policy not yet formally enunciated. (dictionary.com)
C17042	Public_Relations	Sociology	Public Relations	Public relations (PR) is internal and external communication (use of symbols and symbolic acts) to inform or influence specific publics using writing, marketing, advertising, publicity, promotions, and special events. (Wikipedia)
C17043	Puerto_Rico	Country	Puerto Rico|630|PR|PRI|RQ	An island between the Caribbean Sea and the North Atlantic Ocean, east of the Dominican Republic. (CIA World Factbook 2002)
C17044	Pulse_Radiolysis	Physical_Chemical_Techniques	Pulse Radiolysis|Photometry / Spectrum Analysis, Pulse Radiolysis	Pulse Radiolysis is a technique of exposing a sample of material to a beam of highly accelerated electrons to initiate fast reaction events occurring between 10-11 and 102 s after energy absorption. The technique is used to study fast reactions of biologically important molecules, e.g. the kinetics and thermodynamics of redox processes and electron-transfer reactions, enzymatic processes and structural effects which are revealed by physical or kinetic properties. (NCI2005)
C17045	Qatar	Country	Qatar|634|QA|QAT	A country in the Middle East, occupying a peninsula bordering the Persian Gulf and Saudi Arabia. (CIA World Factbook 2002)
C17046	Quality_of_Care	Public_Health_Administration	Quality of Care|QOC	The degree or grade of excellence with respect to medical services received by patients, administered by providers or programs, in terms of technical competence, need, appropriateness, acceptability, humanity and structure. (Glossary of Health Care Terms; http://www.deha.org/Glossary/GlossaryHome.htm)
C17047	Quality_of_Life	Personal_Attribute	Quality of Life|QOL|Quality-of-Life|quality of life	The overall enjoyment of life. Many clinical trials measure aspects of an individual's sense of well-being and ability to perform various activities to assess the effects of cancer and its treatment on the quality of life.
C17048	Questionnaire	Survey	Questionnaire|Questionnaires	Questionnaire; a form containing a set of questions; submitted to people to gain statistical information.
C17049	Race	Population_Group	Race|Racial Group	An arbitrary classification of taxonomic group that is a division of a species; usually arise as a consequence of geographical isolation within a species and characterised by shared heredity, physical attributes and behavior, and in case of humans, by common history, nationality, or geographic distribution.
C17050	Electromagnetic_Radiation	Physical_Phenomena_or_Properties	Electromagnetic Radiation|Radiation|Radiation, Electromagnetic|Radiation-Total|radiation|radiation (unspecified type)	Energy released in the form of particles or electromagnetic waves. Common sources of radiation include radon gas, cosmic rays from outer space, and medical x-rays.
C17051	Radiation_Sensitivity	Properties_or_Attributes	Radiation Sensitivity	The ability of some cells or tissues to withstand ionizing radiation without serious injury. Tolerance depends on the species, cell type, and physical and chemical variables, including RADIATION-PROTECTIVE AGENTS and RADIATION-SENSITIZING AGENTS.
C17052	Ionizing_Radiation	Electromagnetic_Radiation	Ionizing Radiation|Radiation, Ionizing|Radiation-Ionizing Total	High-energy radiation capable of producing ionization in substances through which it passes.
C17053	Nonionizing_Radiation	Electromagnetic_Radiation	Nonionizing Radiation|Radiation Non-Ionizing, Other|Radiation, Non-Ionizing|Radiation, Nonionizing|Radiation-Non-Ionizing Total	Electromagnetic radiation which does not produce ions in matter through which it passes. Its wavelengths are generally greater than those of far ultraviolet radiation and range through the longest radio waves.
C17054	Radioactivity	Electromagnetic_Radiation	Radioactivity	The quality of emitting or the emission of corpuscular or electromagnetic radiations consequent to nuclear disintegration, a natural property of all chemical elements of atomic number above 83 and possible of induction in all other known elements.
C17055	Radiation_Biology	Biology	Radiation Biology|Radiobiology	The study of the mechanisms and biological effects of ionizing radiation, including repair processes.
C17056	Radiochemistry	Health_Physics	Radiochemistry|Radiation Chemistry	Radiochemistry the science concerned with the effects of ionizing or nuclear radiation on chemical reactions or materials. (from On-line Medical Dictionary)
C17057	Radioimmunoassay	Immunologic_Techniques	Radioimmunoassay|Immunologic, Radioimmunoassay	Radioimmunoassay (RIA) is an immunological technique, which quantitatively determines antigen and antibody concentrations, using a radioactively labeled substance (radioligand), either directly or indirectly.(NCI2005)
C17058	Radiologic_Health	Environmental_Health_Sciences	Radiologic Health|Radiological Health
C17059	Radiology	Medical_Specialty	Radiology|RAD|Radiology, General|radiology	The branch of medical science dealing with the medical use of X-rays or other penetrating radiation.
C17060	HRAS_Gene	RAS_Family_Gene	HRAS Gene|H-ras|HRAS1|RAS Gene|RASH1	This gene encodes Harvey ras that binds GTP and transmits signals from growth factor receptors.(from LocusLink)
C17061	RAS_Family_Oncogene	G-Protein_Oncogene	RAS Family Oncogene|Oncogene RAS|RAS|RAS Oncogene|Retrovirus Associated Sequence Oncogene	Family of retrovirus-associated DNA sequences (ras) originally isolated from Harvey (H-ras, Ha-ras, rasH) and Kirsten (K-ras, Ki-ras, rasK) murine sarcoma viruses. Ras genes are widely conserved among animal species and sequences corresponding to both H-ras and K-ras genes have been detected in human, avian, murine, and non-vertebrate genomes. The closely related N-ras gene has been detected in human neuroblastoma and sarcoma cell lines. All genes of the family have a similar exon-intron structure and each encodes a p21 protein. Critically involved in cell activation and replication in many cell types, and disruption of its regulation can lead to uncontrolled growth.
C17062	Beta_Adrenergic_Receptor	G_Protein-Coupled_Receptor	Beta Adrenergic Receptor	Expressed by Beta Adrenergic Receptor Genes in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Beta Adrenergic Receptors are one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Beta-adrenergic receptors respond to blocking agents such as propranolol and to activating agents such as isoproterenol. Beta-1 type receptors mediate lipolysis and increase cardiac rate and force of contraction; beta-2 type receptor activation promotes bronchial and vascular smooth muscle relaxation. When coupled to adenylate cyclase through Gs protein, Beta Adrenergic Receptor stimulation results in increased intracellular cyclic AMP. (NCI)
C17063	Androgen_Receptor	Steroid_Hormone_Receptor	Androgen Receptor|AR|DHTR|Dihydrotestosterone Receptor|NR3C4	Encoded by human AR Gene (NR3 Family), the Androgen Receptor transcription factor regulates gene expression, cell proliferation, and differentiation. AR has 3 domains: N-terminal modulating (exon 1), DNA-binding (two C4 Zinc fingers, exons 2-3), and C-terminal hormone-binding (5 remaining exons). Polymorphic N-terminal poly-Gln tracts bind RAN, enhancing transactivation; decreased with increased poly-Gln length. An 87-kD (AR-A) isoform lacks a normal N-terminus, seen in the 110 kD (AR-B) form; A and B may differ in function. Ligand bound receptor translocates to the nucleus, homodimerizes, binds DNA, and stimulates transcription. Polyglutamine expansion causes Kennedy's disease. Other mutations are associated with androgen insensibility syndrome. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C17064	MAS1_Protein	G_Protein-Coupled_Receptor	MAS1 Protein|Angiotensin Receptor|MAS1|MAS1 Gene Product	A product of the MAS1 Gene, an oncogene isolated from DNA of a human epidermoid carcinoma cell line.  Based on its deduced amino acid sequence, the MAS1 gene product contains 7 potential transmembrane domains. The MAS1 protein is, therefore, probably an integral membrane protein.  The structure of the MAS oncogene indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, which is described as a '7-transmembrane segment' following the prediction that these hydrophobic segments form membrane-spanning alpha-helices.  It is predicted that it would encode a peptide receptor with mitogenic activity which would act through the inositol lipid signaling pathways. Expression in Xenopus oocytes and a transfected mammalian cell line demonstrated that the MAS gene product is a functional angiotensin receptor. (from OMIM)
C17065	T-Cell_Receptor	Protein_or_Riboprotein_Complex	T-Cell Receptor|MHC Receptor|Major Histocompatibility Complex Receptor|TCR	Heterodimeric antigen receptors present on the surface of T-cells.  Two T-cell antigen receptors have been identified, consisting of heterodimeric 40-55 kD Ig-like alpha/beta or gamma/delta integral membrane glycoproteins.  Genes for TCR alpha, beta, gamma, and delta subunits are assembled during T-cell development by somatic rearrangement of germline gene segments, resembling B-cell Ig genes in their mechanisms of diversity generation and activation of expression.  Alpha/beta heterodimers are found on helper and cytotoxic T-cells and are specific for antigenic peptides presented by MHC gene products.  T-cells expressing gamma/delta heterodimers directly recognize proteins and non-proteinacious phospho-ligands.  T-cell receptors are non-covalently associated with CD3, forming the TCR-CD3 complex.  TCRs activate MAPKs and JNK1 through the CD3 antigens, the adaptor protein LAT, and tyrosine kinases LCK and ZAP70.  (from OMIM and NCI)
C17066	Dopamine_Receptor	G_Protein-Coupled_Receptor	Dopamine Receptor	family of G protein-coupled receptors of two general classes: D1 (- A, -B) stimulation increases intracellular cAMP, whereas D2, D3, or D4 stimulation decreases cAMP, increases K+ flux, or decreases Ca++ flux.
C17067	Cell_Surface_Receptor	Receptor	Cell Surface Receptor|Receptor, Cell Surface
C17068	Epidermal_Growth_Factor_Receptor	ErbB_Receptor_Family_Protein	Epidermal Growth Factor Receptor|EGF Receptor|EGFR|ERBB Protein|Epidermal Growth Factor Receptor Protein-Tyrosine Kinase|ErbB1|HER1|Urogastrone Receptor|c-erbB-1|epidermal growth factor receptor|erbB-1|proto-oncogene protein c-erbB-1	Epidermal growth factor receptor. The protein found on the surface of some cells and to which epidermal growth factor binds, causing the cells to divide. It is found at abnormally high levels on the surface of many types of cancer cells, so these cells may divide excessively in the presence of epidermal growth factor.
C17069	Estrogen_Receptor	Steroid_Hormone_Receptor	Estrogen Receptor|ER|ER+|ER-|Estradiol Receptor|estrogen receptor	ER. Protein found on some cancer cells to which estrogen will attach.
C17070	Fc_Receptor	Cell_Surface_Receptor	Fc Receptor|FcR	Receptors found on the cell surface of some B-lymphocytes, T-lymphocytes, and macrophages, which recognize the Fc (constant region fragment) portion of immunoglobulin molecules.
C17071	Glucocorticoid_Receptor	Steroid_Hormone_Receptor	Glucocorticoid Receptor|Glucocorticoid Receptor, Lymphocyte|NR3C1|Nuclear Receptor Subfamily 3, Group C, Member 1	Widely expressed by human NR3C1 Gene (NR3 Family) as 6 isoforms, phosphorylated cytoplasmic (inactive)/hyperphosphorylated nuclear (active) Glucocorticoid Receptor contains a (N) modulating domain, a DNA-binding domain, and a (C) steroid-binding domain. Alpha-A (777-aa, 86-kDa precursor) predominates. Complexed with HSP90, HSP70, and FKBP5 or PPP5C, activate GR is transported (by dynein/FKBP4) to the nucleus and binds to target GREs as a homodimeric or heterodimeric (NR3C2/RXR) transcription factor and modulates other transcription factors to regulate blood glucose concentration, protein/fat metabolism, inflammatory responses, cell proliferation, and differentiation. GR appears to interact with NRIP1, POU2F1, POU2F2, STAT5A, STAT5B, SMARCA4, CREBBP/EP300, TADA2L, p160, NCOA2, and NCOA6. Sumoylation and BAG1 interaction inhibits transactivation. GR defects cause glucocorticoid resistance. (NCI)
C17072	Insulin_Receptor	Protein_Hormone_Receptor	Insulin Receptor|INSR	Human insulin receptor protein (1382 aa, 156 kD, values for precursor protein) is encoded by the human insulin receptor (INSR) gene. There are two isoforms of the INSR protein, which is a transmembrane protein located on the cell surface that functions as a receptor for insulin and exhibits tyrosine-protein kinase activity. Binding of insulin causes tyrosine autophosphorylation of INSR protein, which activates the receptor and results in metabolic changes that increase the uptake of glucose into liver, muscle and adipose tissues. Dysfunctional insulin receptors are associated with insulin resistance, a condition that can result in diabetes mellitus and, in extreme cases, Donohue syndrome or Rabson-Mendenhall syndrome.
C17073	Interleukin-2_Receptor_Alpha	Cytokine_Receptor	Interleukin 2 Receptor Alpha|CD25|IL-2 Receptor|IL-2R|IL2R|IL2RA|Interleukin 2 Receptor|Interleukin 2 Receptor, Alpha|Low Affinity Interleukin 2 Receptor	The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolysis. (LocusLink)
C17074	Low_Density_Lipoprotein_Receptor	Cell_Surface_Receptor	Low Density Lipoprotein Receptor|LDL Receptor|LDLR|Low-Density Lipoprotein Receptor	The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. (LocusLink)
C17075	Progesterone_Receptor	Steroid_Hormone_Receptor	Progesterone Receptor|PGR|PgR|Pr	Progesterone receptor negative.  Breast cancer cells that do not have a protein (receptor molecule) to which progesterone will attach. Breast cancer cells that are PR- do not need the hormone progesterone to grow and usually do not respond to hormonal therapy.
C17076	Prolactin_Receptor	Protein_Hormone_Receptor	Prolactin Receptor	The Prolactin Receptor binds prolactin, initiating the cellular response to the hormone.  The receptor is found in breast, placenta, liver, testes, kidneys, ovaries, and other organs.  The prolactin receptor is homologous to members of the cytokine receptor superfamily, such as GHR, IL2R, IL3R, IL4R, IL6R, IL7R, EPOR, and GMCSFR.  PRLR isoforms differ in the length of their cytoplasmic domains.  The short form acts as a dominant-negative inhibitor, forming inactive heterodimers that inhibit Janus kinase 2 activation.  (from OMIM 176761 and NCI)
C17077	Purinergic_Receptor	G_Protein-Coupled_Receptor	Purinergic Receptor	Cell surface proteins that bind purines with high affinity and trigger intracellular changes which influence the behavior of cells. The best characterized classes of purinergic receptors in mammals are the P1 receptors, which prefer adenosine, and the P2 receptors, which prefer ATP or ADP.
C17078	Thyroid_Hormone_Receptor	Nuclear_Hormone_Receptor_Superfamily	Thyroid Hormone Receptor
C17079	Transferrin_Receptor	Cell_Surface_Receptor	Transferrin Receptor	Homodimeric human Transferrin Receptors (M28B Peptidase Family) are type II membrane proteins involved in the cellular import of transferrin-bound iron and appear necessary for iron metabolism, cell function, and erythrocyte differentiation. (NCI)
C17080	Viral_Receptor	Cell_Surface_Receptor	Viral Receptor	Cell surface molecules that are capable of interacting with virus particles, thereby mediating their entry into the cell or otherwise eliciting a cellular response.
C17081	Recombinant_Protein	Protein_Organized_by_Origin	Recombinant Protein	Proteins produced by genes or recombinant DNA that has been artificially engineered and inserted into a heterologous host. Recombinant proteins are used extensively by investigators of disease pathways to  identify protein targets for potential drug therapies.
C17082	Recombination	DNA_Sequence_Rearrangement	Recombination|DNA Recombination	A natural process of exchange of DNA between chromosomes during mitosis; not recombinant DNA, which applies to artificial DNA constructs. The production of new arrangements of genes by various mechanisms such as assortment and segregation, crossing over, gene conversion, transformation, conjugation, transduction, F-duction, or mixed infection of viruses.
C17083	Regeneration	Host_Defense_Mechanism	Regeneration|Plasticity/Regeneration/Transplantation	Reproduction or reconstitution of a lost or injured part. (NCI)
C17084	REL_Gene	Transcription_Factor_Gene	REL Gene|Avian Reticuloendotheliosis Viral Oncogene Homolog|REL|Sloan-Kettering Viral Oncogene Homolog|v-REL Avian Reticuloendotheliosis Viral Oncogene Homolog	Human REL Gene (REL/Dorsal Family) at 2p13-p12 encodes REL Protein, which may play a role in differentiation and lymphopoiesis. (NCI)
C17085	Religion	Belief_System	Religion|RELGN	A personal or institutionalized system grounded in belief and reverence for a supernatural power or powers regarded as creator and governor of the universe. (from dictionary.com)
C17086	Repression	Mental_Process	Repression	A psychological mechanism utilized by humans to shield themselves from painful memories or traumatic events. This protection entails the exclusion of memories or thoughts from consciousness.
C17087	Reproduction	Reproductive_Process	Reproduction	The generation of offspring by living organisms.
C17088	Request_for_Proposals	Funding_Opportunities	Request for Proposals|RFP	In a Request for Proposals (RFPs) the Government states work to be undertaken or a problem to be solved.  Respondents compete for a common requirement open to all eligible offerors/bidders. Proposals are evaluated using technical and business evaluation criteria and generally involve negotiations. Bids are awarded to the bidder who is responsible and offers the lowest overall price. (from Acquisition Program)
C17089	Research_Personnel	Population_Group	Research Personnel|investigator	A researcher in a clinical trial or clinical study.
C17090	Research_Support	Funding	Research Support	This includes all types of grants, cooperative agreements, and research contracts that support research directly and for which individuals and/or projects have been peer-reviewed.
C17091	Respiration	Respiratory_Process	Respiration	Distinct from cell or tissue respiration, Respiration is the act of breathing with the lungs and consists of inspiration, or taking ambient air into the lungs, and expiration, or expelling modified air that contains more carbon dioxide than the air taken in. (NCI)
C17092	Respiratory_Physiology	Physiology	Respiratory Physiology	Study of the functions and activities of the respiratory tract as a whole or of any of its parts.
C17093	Restriction_Fragment_Length_Polymorphism	Genetic_Marker	Restriction Fragment Length Polymorphism|Molecular Biology, Restriction Fragment Length Polymorphisms|Polymorphism, Restriction Fragment Length|RFLP	Restriction fragment length polymorphism (RFLP). Variation occurring within a species in the length of DNA fragments generated by a specific endonuclease. Such variations are generated by mutations that create or abolish recognition sites for these enzymes.
C17094	Restriction_Enzyme_Mapping	Restriction_Enzyme_Analysis	Restriction Enzyme Mapping|Restriction Enzyme Analysis	Use of restriction endonucleases to generate a physical map of genomes, genes, or other segments of DNA.
C17095	Reunion	Country	Reunion|638|RE|REU	An Southern Africa, occupying an island in the Indian Ocean, east of Madagascar. (CIA World Factbook 2002)
C17096	Reverse_Transcriptase	DNA_Polymerase	Reverse Transcriptase|EC 2.7.7.49|RNA-Dependent DNA Polymerase	RNA-dependent DNA polymerase.  Enzyme involved in the replication of retroviruses, synthesizing a DNA viral intermediate that is then integrated into the host genome as a provirus.
C17097	Reverse_Transcription	Replication-Associated_Process	Reverse Transcription	The action of copying RNA into DNA by reverse transcriptase.
C17099	Rheumatology	Internal_Medicine	Rheumatology
C17100	Ribonuclease	Esterase	Ribonuclease|Ribonuclease Family Protein	Enzymes that catalyze the hydrolysis of RNA
C17101	Ribonucleotide_Reductase	Protein_or_Riboprotein_Complex	Ribonucleotide Reductase|EC 1.17.4.-	Ribonucleotide Reductase is a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. It consists of two subunits, M1 Chain and M2 Chain. Complex allosteric control, mediated by deoxynucleoside triphosphates, and by ATP bound to the M1 subunit prevents DNA replication and cell proliferation. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. (NCI)
C17102	Risk	Conceptual_Entities	Risk	Risk is the potential future harm that may arise from some present action. It is often combined or confused with the probability of an event which is seen as undesirable. (from WIkipedia)
C17103	Risk_Factor	Diagnostic_or_Prognostic_Factor	Risk Factor|risk factor	Any aspect of an individual's life, behavior, an environmental exposure or an inborn or inherited characteristic, which increases the likelihood of a disease, condition or injury.
C17104	DNA-Directed_RNA_Polymerase	RNA_Polymerase	DNA-directed RNA Polymerase|DNA-Dependent RNA Polymerase|EC 2.7.7.6	Enzymes that catalyze the template-directed stepwise addition of ribonucleotides to the 3' end of a growing RNA chain using a single-stranded DNA template. The reaction is important in the flow of information from DNA to proteins. Three different forms of the polymerase have been identified and characterized.
C17105	RNA-Directed_RNA_Polymerase	RNA_Polymerase	RNA-Directed RNA Polymerase|EC 2.7.7.48|RNA-Dependent RNA Polymerase	An enzyme that catalyzes the template-directed addition of ribonucleotides to the 3' end of a growing RNA chain. The enzyme utilizes single-stranded RNA as a template.
C17106	RNA_Splicing	RNA_Processing	RNA Splicing|Splicing	Removal of introns from mRNA precursors and the reattachment or annealing of exons.
C17107	tRNA_Methyltransferase	Methyltransferase	tRNA Methyltransferase|EC 2.1.1.31-36
C17108	Romania	Country	Romania|642|RO|ROU	A country in Southeastern Europe, bordering the Black Sea, between Bulgaria and Ukraine. (CIA World Factbook 2002)
C17109	Rural_Health	Patterns_of_Care	Rural Health
C17110	Rural_Population	Underserved_Population	Rural Population|Rural Populations	Populations living away from the congestion of city or suburb.
C17111	Russia	Country	Russia|643|RS|RU|RUS|Russian Federation	A country in Northern Asia (that part west of the Urals is sometimes included with Europe), bordering the Arctic Ocean, between Europe and the North Pacific Ocean. (CIA World Factbook 2002)
C17112	Rwanda	Country	Rwanda|646|RW|RWA	A country in Central Africa, east of Democratic Republic of the Congo. (CIA World Factbook 2002)
C17113	Saint_Lucia	Country	Saint Lucia|662|LC|LCA|ST	A country in the Caribbean, occupying an island between the Caribbean Sea and North Atlantic Ocean, north of Trinidad and Tobago. (CIA World Factbook 2002)
C17114	Saint_Vincent_and_the_Grenadines	Country	Saint Vincent and the Grenadines|670|VC|VCT	A country in the Caribbean, comprised of islands in the Caribbean Sea, north of Trinidad and Tobago. (CIA World Factbook 2002)
C17115	San_Marino	Country	San Marino|674|SM|SMR	A country in Southern Europe, an enclave in central Italy. (CIA World Factbook 2002)
C17116	Sao_Tome_and_Principe	Country	Sao Tome and Principe|678|ST|STP|TP	A country in Western Africa, comprised of islands in the Gulf of Guinea, straddling the Equator, west of Gabon. (CIA World Factbook 2002)
C17117	Saudi_Arabia	Country	Saudi Arabia|682|SA|SAU	A country in the Middle East, bordering the Persian Gulf and the Red Sea, north of Yemen. (CIA World Factbook 2002)
C17118	School	Sites_of_Care_Delivery	School|Schools	An educational institution.
C17119	Cellular_Secretion	Transmembrane_Transport	Cellular Secretion|Secretion|Secretion, Cellular	Production by a cell or aggregation of cells (a gland) of a physiologically active substance and its movement out of the cell or organ in which it is formed.  Discharge across the cell membrane, into the intracellular space or ducts, of endogenous substances resulting from the activity of intact cells of glands, tissues, or organs.
C17120	Support_Group	Social_Group	Support Group|Self-Help Group|support group	A group of people with similar disease who meet to discuss how better to cope with their disease and treatment.
C17121	Senegal	Country	Senegal|686|SEN|SG|SN	A country in Western Africa, bordering the North Atlantic Ocean, between Guinea-Bissau and Mauritania. (CIA World Factbook 2002)
C17122	Serine_Proteinase_Inhibitor	Enzyme_Inhibitor_Protein	Serine Proteinase Inhibitor	Compounds that inhibit serine endopeptidases. Serine proteinase inhibitors can be either exogenous or endogenous. Endogenous moieties occur naturally; however, exogenous inhibitors can be introduced to provide therapeutic benefit, such as antiretroviral or antiviral pharmaceuticals.
C17123	Serine_Protease	Protease	Serine Protease	Proteases that have a serine residue in the active center of the enzyme. These enzymes catalyze the hydrolysis of covalent peptidic bonds by serine nucleophilic attack. Serine proteases participate in a wide range of functions in the body, including blood clotting, inflammation, and digestion.
C17124	Serpin	Serine_Proteinase_Inhibitor	Serpin	Irreversible serine proteinase inhibitors that exert their action on peptidases. Serpins can be localized inside, or outside of the cell, and are found in all groups of organisms with the exception of fungi. In human plasma, serpins represent approximately 2% of the total protein present.
C17125	Serum_Globulin	Serum_Protein	Serum Globulin|Globulin
C17126	Serum_Protein	Protein_Organized_by_Location	Serum Protein|Plasma Protein	Dissolved proteins of blood plasma.  These mainly consist of albumins and globulins and include antibodies and blood-clotting proteins.
C17127	Sex_Behavior	Personal_Behavior	Sex Behavior|Sexual Behavior	Sexual behavior is a form of physical intimacy that can be directed to reproduction (one possible goal of sexual intercourse) and/or to enjoying the body of someone else; activities associated with sexual intercourse. (from Wikipedia)
C17128	Sex_Hormone-Binding_Globulin	Ligand_Binding_Protein	Sex Hormone-Binding Globulin|ABP|Androgen-Binding Protein|SHBG|Sex Steroid-Binding Protein|Testis-Specific Androgen-Binding Protein|Testosterone Estradiol Binding Globulin	Expressed as 2 alternative isoforms in Sertoli cells and liver by human SHBG Gene, 402-aa 44-kDa (precursor) homodimeric Sex Hormone-Binding Globulin is a secreted beta-globulin plasma glycoprotein containing 2 laminin G-like domains that specifically bind 5-alpha-dihydrotestosterone, testosterone, or 17-beta-estradiol. An androgen transport protein, SHBG regulates the plasma metabolic clearance rate of steroid hormones by controlling plasma concentration and may be involved in receptor-mediated processes as well. (NCI)
C17129	Seychelles	Country	Seychelles|690|SC|SE|SYC	A country in Eastern Africa, comprised of a group of islands in the Indian Ocean, northeast of Madagascar. (CIA World Factbook 2002)
C17130	Sierra_Leone	Country	Sierra Leone|694|SL|SLE	A country in Western Africa, bordering the North Atlantic Ocean, between Guinea and Liberia. (CIA World Factbook 2002)
C17131	Sigmoidoscopy	Endoscopy	Sigmoidoscopy|Proctosigmoidoscopy|proctosigmoidoscopy|sigmoidoscopy	(PROK-toe-sig-moid-OSS-ko-pee) An examination of the rectum and the lower part of the colon using a thin, lighted tube called a sigmoidoscope.
C17132	Signaling_Pathways	Biochemical_Pathway	Signaling Pathway|Signal Transduction Pathway	An elaboration of the known or inferred interactions involved in a signal transduction pathway.
C17133	Signal_Transduction	Cell_Signaling_Process	Signal Transduction|Cell Communication and Signaling|Cell Signaling|Intracellular Communication and Signaling|Signaling	Any process by which a cell converts one kind of signal or stimulus into another. Processes referred to as signal transduction often involve a sequence of biochemical reactions inside the cell, which are carried out by enzymes and linked through second messengers. (from Wikipedia)
C17134	Singapore	Country	Singapore|702|SG|SGP|SN	A country in Southeastern Asia, comprised of islands between Malaysia and Indonesia. (CIA World Factbook 2002)
C17135	Oncogene_SIS	PDGFB_Gene	Oncogene SIS|Oncogene V-SIS|Oncogene, V-SIS|Simian Sarcoma Virus Oncogene	Human Oncogene SIS is a mutated variant of PDGFB Gene (PDGF/VEGF Family), which encodes 2 alternative isoforms of 241-aa 27-kDa (precursor) Platelet-Derived Growth Factor-Beta Chain, a potent mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released by platelets upon wounding to stimulate adjacent cell growth; PDGF activates a RAS/PIK3/AKT1/IKK/NFKB1 pathway. PDGFB can exist as a disulfide-linked homodimer or heterodimer with Platelet-Derived Growth Factor Alpha. AA, BB, and AB, dimers bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation. PDGFB mutations are associated with meningioma. Reciprocal t(17;22)(q22;q13) translocations with COL1A1 result in unregulated growth factor expression and are associated with DFSP. Oncogene SIS disrupts normal cell function.
C17136	Sister_Chromatid_Exchange	Homologous_Recombination	Sister Chromatid Exchange	An exchange of homologous segments of genetic material between the sister chromatids of a chromosome, either between the sister chromatids of a meiotic tetrad or between the sister chromatids of a duplicated somatic chromosome. Its frequency is increased as a result of inordinate chromosomal fragility due to genetic or environmental factors such as ultraviolet or ionizing radiation and other mutagenic agents, and is particularly high in Bloom Syndrome.
C17137	Skin_Test	Procedure	Skin Test|Skin Test Vaccine|skin test	A preparation of an antigenic component of an infectious agent that is administered to a patient in order to determine whether previous exposure to the agent has occurred, and/or to assess the integrity of the patient's cellular immune system.  Depending on the clinical situation, the appearance of a delayed (cellular) hypersensitivity response, which manifests as an area of induration and erythema at the injection site, i.e. a positive test result, may indicate previous exposure to a particular infectious agent. (NCI04)
C17138	Slovenia	Country	Slovenia|705|SI|SVN	A country in Central Europe, bordering the Adriatic Sea, between Austria and Croatia. (CIA World Factbook 2002)
C17139	Olfaction	Sensory_Process	Olfaction|Smell	Smell; the faculty of smell, the sensation that results when olfactory receptors in the nose are stimulated by particular chemicals in gaseous form.
C17140	Passive_Smoke_Exposure	Environmental_Exposure	Passive Smoke Exposure|Passive Smoking|Smoking, Passive|Smoking, Tobacco and Cancer-Passive Smoking	Exposure to tobacco smoke products among individuals who do not smoke. This can result from sharing space with a smoker or from placental transfer from mother to fetus.
C17141	Social_Sciences	Occupation_or_Discipline	Social Sciences	The social sciences comprise the scientific study of the human aspects of the world. They are also known as social studies. Psychology studies the human mind, sociology examines human society, political science studies the governing of groups and economics concerns itself with the allocation of wealth in society. (Wikipedia)
C17142	Social_Work	Sociology	Social Work|Social Service	Social work; any of various services designed to aid the poor and aged and to increase the welfare of children. (WordNet)
C17143	Sociology	Social_Sciences	Sociology
C17144	Medical_Sociology	Sociology	Medical Sociology	Medical sociology is the study of individual and group behaviors with respect to health and illness.  Medical sociology is concerned with individual and group responses aimed at assessing well-being, maintaining health, acting upon real or perceived illness, interacting with health care systems, and maximizing health in the face of physiologic or functional derangement. It also analyzes the impact of the psychological conditions resulting from our environment on our health. (from Wikipedia)
C17145	Sodium_Channel	Ion_Channel	Sodium Channel
C17146	Computer_Program	Diagnostic_Therapeutic_and_Research_Equipment	Computer Program|Software	A set of coded instructions, which a computer follows in processing data, performing an operation, or solving a logical problem, upon execution of the program.
C17147	Computer_Software_Engineering	Computer_Sciences	Computer Software Engineering|Computer Software Development
C17148	Solomon_Islands	Country	Solomon Islands|090|BP|SB|SLB	A group of islands in the South Pacific Ocean, east of Papua New Guinea. (CIA World Factbook 2002)
C17149	Somalia	Country	Somalia|706|SO|SOM	A country in Eastern Africa, bordering the Gulf of Aden and the Indian Ocean, east of Ethiopia. (CIA World Factbook 2002)
C17150	SOS_Function	Excision_Repair	SOS Function	A series of erroneous bacterial processes that are utilized to maintain the integrity of DNA during cellular metabolism. These functions are involved in maintenance activities such as DNA repair, but they are also involved in apoptosis and mitotic inhibition.
C17151	South_Africa	Country	South Africa|710|SF|ZA|ZAF	A country in Southern Africa, at the southern tip of the continent of Africa. (CIA World Factbook 2002)
C17152	Spain	Country	Spain|724|ES|ESP|SP	A country in Southwestern Europe, bordering the Bay of Biscay, Mediterranean Sea, North Atlantic Ocean, and Pyrenees Mountains, southwest of France. (CIA World Factbook 2002)
C17153	Medical_Specialty	Medicine	Medical Specialty|SPEC|Specialty	The branches of medical science that deal with nonsurgical techniques.
C17154	Surgical_Specialty	Surgery	Surgical Specialty|Surgical Profession|Surgical Specialties	Various branches of surgical practice limited to specialized areas.
C17155	Spectroscopy	Physical_Chemical_Techniques	Spectroscopy	The technique of measuring the emission and absorption of different wavelengths (spectra) of visible and non-visible light. This can be done via a spectroscope, which consists of a slit, prism, collimator lens, object lens, and a grating.(NCI2005)
C17156	Mass_Spectrometry	Spectroscopy	Mass Spectrometry|Mass Spec|Mass Spectroscopy|Mass Spectrum|Photometry/Spectrum Analysis, Mass	An analytical technique wherein ions are separate according to their ratio of charge to mass. From the mass spectrum produced, the atomic weight of the particle can be deduced. (North American Lake Management Society Lake Word Glossary)
C17157	Spectroscopy_Raman	Spectroscopy	Spectroscopy, Raman|Spectroscopy, IR/UV/Raman	Emission of electromagnetic energy with a shorter frequency (longer wavelength) than that of the incident monochromatic light.  Arises from the low probability absorption of quanta with a higher energy than that required for a transition: the difference in energy is emitted as a lower frequency (energy) photon.  Allows analysis of vibrational and rotational energy levels using visible incident light.
C17158	Speculum	Medical_Device	Speculum|speculum	(SPEK-yoo-lum) An instrument used to widen an opening of the body to make it easier to look inside.
C17159	Alaryngeal_Speech	Personal_Behavior	Alaryngeal Speech|Alaryngeal Voice Production
C17160	Esophageal_Speech	Alaryngeal_Speech	Esophageal Speech|Speech, Esophageal|esophageal speech	(eh-SOF-a-JEE-al) Speech produced by trapping air in the esophagus and forcing it out again.  It is used after removal of a person's larynx (voice box).
C17161	Spermatogenesis	Gametogenesis	Spermatogenesis	The maturation and propagation of spermatozoa. The process consists of three phases, mitosis, meiosis, and spermiogenesis. This results in a specialized cell that is capable of traversing the male and female reproductive tracts, and has the capability of fertilizing an egg.
C17162	SRC_Family_Gene	Non-Receptor_Tyrosine_Kinase_Gene	SRC Family Gene|SRC Gene
C17163	Sri_Lanka	Country	Sri Lanka|144|CE|LK|LKA	A country in Southern Asia, occupying an island in the Indian Ocean, south of India. (CIA World Factbook 2002)
C17164	Saint_Helena	Country	Saint Helena|654|SH|SHN	Islands in the South Atlantic Ocean, about midway between South America and Africa. (CIA World Factbook 2002)
C17165	Saint_Pierre_and_Miquelon	Country	Saint Pierre and Miquelon|666|PM|SB|SPM	A country in Northern North America, comprised of islands in the North Atlantic Ocean, south of Newfoundland (Canada). (CIA World Factbook 2002)
C17166	Staphylococcus_aureus_Protein-A	Bacterial_Protein	Staphylococcus aureus Protein A|S. aureus protein A|Staph. Protein A	A protein that resides in the microbial wall of staphylococcus aureus and interferes with opsonization by binding to the Fc portion of immunoglobulin. The protein has a deleterious effect on the epithelial cells that line the respiratory tract, and plays a role in the induction of pneumonia. Protein A also initiates polymorphonuclear cell migration into airway passages via TNFR1 activation.
C17167	Statistics	Mathematics	Statistics	A branch of applied mathematics concerned with the collection and interpretation of quantitative data and the use of probability theory to estimate population parameters.
C17168	Stent	Prosthesis	Stent|stent	A device placed in a body structure (such as a blood vessel or the gastrointestinal tract) to provide support and keep the structure open.
C17169	Cell_Fraction	Specimen	Cell Fraction	Components of a cell produced by various separation techniques which, though they disrupt the delicate anatomy of a cell, preserve the structure and physiology of its functioning constituents for biochemical and ultrastructural analysis.
C17170	Sudan	Country	Sudan|736|SD|SDN|SU	A country in Northern Africa, bordering the Red Sea, between Egypt and Eritrea. (CIA World Factbook 2002)
C17171	Sulfotransferase	Transferase	Sulfotransferase|EC 2.8.2	Enzymes that catalyze the transfer of a sulfate group from 3'-phosphoadenylyl sulfate (active sulfate) to the hydroxyl group of an acceptor, which produces the sulfated derivative and 3'-phosphoadenosine 5'-phosphate. The enzymes are also involved in both the posttranslational sulfation of proteins and sulfate conjugation of exogenous chemicals and bile acids.
C17172	Superoxide_Dismutase	Oxidoreductase	Superoxide Dismutase|E.C. 1.15.1.1	Proteins that protect cells against elevated levels of superoxide a reactive oxygen species. These antioxidant enzymes catalyze the formation of molecular oxygen and hydrogen peroxide from the superoxide anion. They are also potential therapeutic agents in diseases related to oxidative stress and in the regulation of the ageing process.
C17173	Surgery	Medical_Science	Surgery	The branch of medical science that treats disease or injury by operative procedures.
C17174	Oral_Surgery	Surgical_Specialty	Oral Surgery|Surgery, Oral
C17175	Suriname	Country	Suriname|740|NS|SR|SUR	A country in Northern South America, bordering the North Atlantic Ocean, between French Guiana and Guyana. (CIA World Factbook 2002)
C17176	Survey	Document_Type	Survey|Survey Instrument	A document used in a method of data collection that involves interviewing (or giving questionnaires to) a representative and often large group of people.
C17177	Survival	Conceptual_Entities	Survival|SRVL|Survivorship|Survivorship Issues	Continuance of life or existence especially under adverse conditions; includes methods and philosophy of survival.
C17178	Svalbard_and_Jan_Mayen	Country	Svalbard and Jan Mayen|744|SJ|SJM	Islands between the Arctic Ocean, Barents Sea, Greenland Sea, and Norwegian Sea, northeast of Iceland and north of Norway.  (from CIA World Factbook 2002)
C17179	Swaziland	Country	Swaziland|748|SWZ|SZ|WZ	A country in Southern Africa, between Mozambique and South Africa. (CIA World Factbook 2002)
C17180	Sweden	Country	Sweden|752|SE|SW|SWE	A country in Northern Europe, bordering the Baltic Sea, Gulf of Bothnia, Kattegat, and Skagerrak, between Finland and Norway. (CIA World Factbook 2002)
C17181	Switzerland	Country	Switzerland|756|CH|CHE|SZ	A country in Central Europe, east of France, north of Italy. (CIA World Factbook 2002)
C17182	Syria	Country	Syria|760|SY|SYR|Syrian Arab Republic	A country in the Middle East, bordering the Mediterranean Sea, between Lebanon and Turkey. (CIA World Factbook)
C17183	Tajikistan	Country	Tajikistan|762|TI|TJ|TJK	A country in Central Asia, west of China. (CIA World Factbook 2002)
C17184	Taiwan	Country	Taiwan|158|TW|TWN	A group of islands bordering the East China Sea, Philippine Sea, South China Sea, and Taiwan Strait, north of the Philippines, off the southeastern coast of China. (CIA World Factbook 2002)
C17185	Tanzania	Country	Tanzania|834|TZ|TZA|United Republic of Tanzania	A country in Eastern Africa, bordering the Indian Ocean, between Kenya and Mozambique. (CIA World Factbook 2002)
C17186	TAT_Protein	Viral_Protein	TAT Protein|TAT|Trans-Activation of Transcription Protein|Trans-Activator of Transcription of HIV|Transactivating Regulatory Protein	A nucleolar, HIV-encoded transcriptional regulator that binds to the RNA Trans-Activating Responsive (TAR) sequence. TAT activates transcription initiation and/or elongation from the LTR promoter. TAT may bind Cyclin T1. (from SWISS-PROT P24738 and NCI)
C17187	Technology	Occupation_or_Discipline	Technology	Technology is the discipline dealing with the art or science of applying scientific knowledge to practical problems.
C17188	Telecommunications	Media	Telecommunications	Communications over distance by telephone, TV, radio, computer modem, or similar means.
C17189	Telophase	M-Phase_Substage	Telophase|Mitotic Telophase	The daughter chromosomes resolve themselves into a reticulum and the daughter nuclei are formed; the cytoplasm then divides, forming two complete daughter cells. (NCI)
C17190	Steroid_5-Alpha-Reductase-2	Oxidoreductase	Steroid 5 Alpha-Reductase 2|3-Oxo-5-Alpha-Steroid 4-Dehydrogenase 2|5 Alpha-Reductase|SR Type 2|SRD5A2	catalyzes the reduction of testosterone to 5 alphadihydrotestosterone.
C17191	Dihydrofolate_Reductase	Oxidoreductase	Dihydrofolate Reductase|DHFR|EC 1.5.1.3	Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids.  It is a drug target.  Variation in gene expression or sequence may alter the efficacy of chemotherapy. (from LocusLink and NCI)
C17192	Thailand	Country	Thailand|764|TH|THA	A country in Southeastern Asia, bordering the Andaman Sea and the Gulf of Thailand, southeast of Burma. (CIA World Factbook 2002)
C17193	Thermodynamics	Physical_Chemistry|Physics	Thermodynamics	branch of chemistry concerned with heat and other energetic characteristics of chemical reactions and states.
C17194	Thermography	Imaging_Technique	Thermography	A diagnostic technique using a thermograph to record the heat produced by different parts of the bod.  It can be used to study blood flow and to detect tumors.
C17195	Thoracic_Surgery	Surgical_Specialty	Thoracic Surgery|Surgery, Thoracic	A branch of medicine dealing with the use of surgery to treat diseases of the chest and lungs. (On-line Medical Dictionary)
C17196	Thoracoscopy	Endoscopy	Thoracoscopy|TRSCPY|thoracoscopy	The use of a thin, lighted tube (called an endoscope) to examine the inside of the chest.
C17197	Coagulation_Factor-III	Coagulation_Factor	Coagulation Factor III|CD142 Antigen|F3|Factor III|Tissue Factor|Tissue Thromboplastin	Human coagulation factor-III protein (295 aa, 33 kDa precursor) is encoded by the human coagulation factor III (thromboplastin, tissue factor) (F3) gene. The factor is a glycoprotein/phospholipid, which functions as a potent high-affinity transmembrane receptor/cofactor for coagulation factor VII. The protein also plays an important role in blood coagulation.
C17198	Thymidine_Kinase	Kinase	Thymidine Kinase|EC 2.7.1.21	Human Thymidine Kinases (Thymidine Kinase Family) catalyze thymidine phosphorylation via ATP to deoxythymidine monophosphate. (NCI)
C17199	Thymidylate_Synthase	Methyltransferase	Thymidylate Synthase|EC 2.1.1.45|TMP synthetase|TYMS|Thymidylate Synthetase|dTMP Synthase	Human thymidylate synthetase protein (312 aa, 36 kDa) is encoded by the human (TYMS) gene. The protein is a conserved transferase enzyme that catalyzes methylene tetrahydrofolate (MTHF)/dUMP conversion to dihydrofolate/dTMP in thymidine triphosphate/deoxyribonucleotide biosynthesis. Thymidylate synthetase competes with the methylene tetrahydrofolate receptor for MTHF and maintains the dTMP pool for DNA replication and repair.
C17200	East_Timor	Country	Timor-Leste|626|East Timor|TL|TLS|TT	A country in Southeastern Asia, northwest of Australia in the Lesser Sunda Islands at the eastern end of the Indonesian archipelago. East Timor includes the eastern half of the island of Timor, the Oecussi (Ambeno) region on the northwest portion of the island of Timor, and the islands of Pulau Atauro and Pulau Jaco. (CIA World Factbook 2002)
C17201	Tissue_Culture	Research_Techniques	Tissue Culture	Originally the maintenance and growth of pieces of explanted tissue (plant or animal) in culture away from the source organism. Now usually refers to the (much more frequently used) technique of cell culture, using cells dispersed from tissues or distant descendants of such cells. (On-line Medical Dictionary)
C17202	Togo	Country	Togo|768|TG|TGO|TO	A country in Western Africa, bordering the Bight of Benin, between Benin and Ghana. (CIA World Factbook 2002)
C17203	Single_Photon_Emission_Computed_Tomography	Computed_Tomography	Single Photon Emission Computed Tomography|Medical Imaging, Single Photon Emission Computed Tomography|SPECT|SPECT imaging|Tomography, Emission-Computed, Single-Photon|tomography, emission computed, single photon
C17204	Computed_Tomography	Tomography	Computed Tomography|CAT|CAT Scan|CAT scan|CATSCAN|CT|CT scan|Computerized Axial Tomography|Computerized Axial Tomography (Computerized Tomography)|computed tomography|computerized axial tomography|computerized tomography|tomography	A method of examining body organs by scanning them with X rays and using a computer to construct a series of cross-sectional scans along a single axis.
C17205	Tonga	Country	Tonga|776|TN|TO|TON	An archipelago in the South Pacific Ocean, about two-thirds of the way from Hawaii to New Zealand. (CIA World Factbook 2002)
C17206	Toxicology	Pharmacology	Toxicology	Toxicology is the branch of pharmacology that deals with the nature and effects and treatments of poisons.
C17207	Transcription_Factor	Transcription_Regulatory_Protein	Transcription Factor	Transcription factors are a diverse group of proteins that bind to DNA at specific promoter or enhancer regions. They also bind to DNA-associated proteins to initiate, stimulate, inhibit or terminate transcription. The proteins are often physically associated in a preinitiation complex and contain structural motifs.
C17208	Transcription	Transcription_Process	Transcription|Gene Transcription|Genetic Transcription|RNA Expression	A genetic process in which single-stranded RNA with base sequence complementary to a region of plus strand DNA is synthesized by DNA-dependent RNA polymerases. Following the binding of RNA polymerase on the DNA promoter regions, the RNA product is synthesized in a 5' to 3' direction, elongating the DNA strand as the polymerase proceeds down the unwinding and rewinding of the DNA helix.
C17209	Transfection	Molecular_Biology_Techniques	Transfection	The process of introduction of DNA into a recipient eukaryote cell and its subsequent integration into the recipient cell's chromosomal DNA, so that the cells or progeny may express the integrated donor gene.(NCI2005)
C17210	Transferase	Enzyme	Transferase|EC 2	Transferases are enzymes transferring a group, for example, the methyl group or a glycosyl group, from one compound (generally regarded as donor) to another compound (generally regarded as acceptor). The classification is based on the scheme "donor: acceptor group transferase". (EC 2 class)
C17211	Transferrin	Beta_Globulin	Transferrin|Granulocyte/Pollen-Binding Protein|Siderophilin|TF
C17212	Transformation	Tumor_Initiation	Transformation|Cell Transformation|Cellular Transformation|transformation	The change that a normal cell undergoes as it becomes malignant.
C17213	Translation	Protein_Expression	Translation|Genetic Translation	The process that occurs at the ribosome whereby the information in mRNA is used to specify the sequence of amino acids in a polypeptide chain.
C17214	Transmission	Pathogenesis	Transmission	The transmission of infectious disease or pathogens. When transmission is within the same species, the mode can be horizontal (disease transmission, horizontal) or vertical (disease transmission, vertical). (NCI)
C17215	Transplantation_Immunology	Immunology	Transplantation Immunology	Studies that pertain to the immunological barriers to transplanting organs and tissues between individuals of different species (xenotransplantation) and between individuals of the same species (allotransplantation).
C17216	Trends	Conceptual_Entities	Trends	Used specifically for analysis of past, present, or future patterns in technology, economics, and social or developmental processes.
C17217	Trinidad_and_Tobago	Country	Trinidad and Tobago|780|TD|TT|TTO	Islands between the Caribbean Sea and the North Atlantic Ocean, northeast of Venezuela. (CIA World Factbook 2002)
C17218	Tryptophanase	Oxygenase	Tryptophanase|L-tryptophanase|TDO2|TPH2|TRPO|Tryptamin 2,3-Dioxygenase|Tryptophan 2,3-Dioxygenase|Tryptophan Oxygenase|Tryptophan Pyrrolase	Encoded by human TDO2 Gene, 406-aa 48-kDa Tryptophanase is a homotetramer that may bind protoheme IV involved in tryptophan catabolism with broad specificity towards tryptamine and derivatives including tryptophan, 5-hydroxytryptophan, and serotonin. (NCI)
C17219	Tubulin	Cytoskeletal_Protein	Tubulin	Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. (from LocusLink)
C17220	Tumor_Marker	Disease_Marker	Tumor Marker|TM-MKR|Tumor Markers|tumor marker	A substance sometimes found in an increased amount in the blood, other body fluids, or tissues and which may mean that a certain type of cancer is in the body. Examples of tumor markers include CA 125 (ovarian cancer), CA 15-3 (breast cancer), CEA (ovarian, lung, breast, pancreas, and gastrointestinal tract cancers), and PSA (prostate cancer). Also called biomarker.
C17221	Tunisia	Country	Tunisia|788|TN|TS|TUN	A country in Northern Africa, bordering the Mediterranean Sea, between Algeria and Libya. (CIA World Factbook 2002)
C17222	Turkey	Country	Turkey|792|TR|TU|TUR	A country in southeastern Europe and southwestern Asia (that portion of Turkey west of the Bosporus is geographically part of Europe), bordering the Black Sea, between Bulgaria and Georgia, and bordering the Aegean Sea and the Mediterranean Sea, between Greece and Syria. (CIA World Factbook 2002)
C17223	Turkmenistan	Country	Turkmenistan|795|TKM|TM|TX	A country in Central Asia, bordering the Caspian Sea, between Iran and Kazakhstan. (CIA World Factbook 2002)
C17224	Turks_and_Caicos_Islands	Country	Turks and Caicos Islands|796|TC|TCA|TK	Two island groups in the North Atlantic Ocean, southeast of The Bahamas. (CIA World Factbook 2002)
C17225	Tuvalu	Country	Tuvalu|798|TUV|TV	An island group consisting of nine coral atolls in the South Pacific Ocean, about one-half of the way from Hawaii to Australia. (CIA World Factbook 2002)
C17226	Tyrosinase	Oxidoreductase	Tyrosinase|EC 1.14.18.1|LB24-AB|Monophenol Monooxygenase|SK29-AB|TYR|Tumor Rejection Antigen AB	A group of copper proteins that also catalyze the reaction of EC 1.10.3.1 catechol oxidase, if only 1,2-benzenediols are available as substrate. (from IUBMB)
C17227	Ubiquitin	Regulatory_Protein	Ubiquitin	Conserved nuclear and cytoplasmic Ubiquitins are synthesized as either a polyubiquitin precursor with head to tail repeats or as a single ubiquitin fused to an unrelated tail protein and are typically involved in selective ATP-dependent nonlysosomal degradation of cellular proteins, histone modification, maintenance of chromatin structure, regulation of gene expression, stress response, and ribosome biogenesis. Ubiquitins often appear to be covalently bound to proteins as a marker for degradation. Ubiquitin-dependent proteolysis by the 26S proteasome plays a pivotal role in cell cycle progression. (NCI)
C17228	Uganda	Country	Uganda|800|UG|UGA	A country in Eastern Africa, west of Kenya. (CIA World Factbook 2002)
C17229	Ukraine	Country	Ukraine|804|UA|UKR|UP	A country in Eastern Europe, bordering the Black Sea, between Poland and Russia. (CIA World Factbook 2002)
C17230	Ultrasound_Imaging	Procedure	Ultrasound Imaging|Medical Imaging, Ultrasound|ULTRASND|US|Ultrasonography|Ultrasound|Ultrasound Test|Ultrasound, Medical|ultrasonography|ultrasound test	(UL-tra-son-OG-ra-fee) A procedure in which sound waves (called ultrasound) are bounced off tissues and the echoes produce a picture (sonogram).
C17231	Ultraviolet_Radiation	Solar_Radiation	Ultraviolet Radiation|Radiation, UV|Sun/Ultra-Violet Rays|UV|UV Radiation|UV radiation|ultraviolet radiation	(ul-tra- VYE-o-let ray-dee-AY-shun) UV radiation. Invisible rays that are part of the energy that comes from the sun.  UV radiation also comes from sun lamps and tanning beds. UV radiation can damage the skin and cause melanoma and other types of skin cancer. UV radiation that reaches the Earth's surface is made up of two types of rays, called UVA and UVB rays. UVB rays are more likely than UVA rays to cause sunburn, but UVA rays pass deeper into the skin. Scientists have long thought that UVB radiation can cause melanoma and other types of skin cancer. They now think that UVA radiation also may add to skin damage that can lead to skin cancer and cause premature aging. For this reason, skin specialists recommend that people use sunscreens that reflect, absorb, or scatter both kinds of UV radiation.
C17232	United_Arab_Emirates	Country	United Arab Emirates|784|AE|ARE|TC	A country in the Middle East, bordering the Gulf of Oman and the Persian Gulf, between Oman and Saudi Arabia. (CIA World Factbook 2002)
C17233	United_Kingdom	Country	United Kingdom|826|GB|GBR|UK	A country in Western Europe, comprising islands, including the northern one-sixth of the island of Ireland, between the North Atlantic Ocean and the North Sea, northwest of France. The US State Department considers Guernsey, Isle of Man, and Jersey as separate entities, each with its own code. (from CIA World Factbook 2002)
C17234	United_States	Country	United States|840|US|USA|United States of America	A country in North America, bordering both the North Atlantic Ocean and the North Pacific Ocean, between Canada and Mexico. (CIA World Factbook 2002)
C17235	Department_of_Health_and_Human_Services	Component_of_NCI_Governance	Department of Health and Human Services|HHS
C17236	Environmental_Protection_Agency	Other_Agency_or_Organization	Environmental Protection Agency|EPA	The EPA is the US Government's watchdog agency responsible for controlling the pollution of air and water, pesticides, radiation hazards and noise pollution. The agency is also involved in research to examine the effects of pollution. (EPA Terminology Reference System)
C17237	Food_and_Drug_Administration	Other_Agency_or_Organization	Food and Drug Administration|FDA	Food and Drug Administration (FDA), is one of the agencies of the U.S. Department of Health and Human Services. It assures the safety of foods and cosmetics, and the safety and efficacy of pharmaceuticals, biological products, radiation emitting products, medical devices, and also, animal feed and drugs.
C17238	Public_Health_Service	Other_Agency_or_Organization	Public Health Service
C17239	Veterans_Administration	Other_Agency_or_Organization	Veterans Administration	A division of the Executive Branch of the United States government concerned with overall planning, promoting, and administering programs pertaining to veterans. The Department of Veterans Affairs (VA) was established March 15, 1989 as a Cabinet-level position.
C17240	Urban_Population	Population_Group	Urban Population	The inhabitants of a city or town, including metropolitan areas and suburban areas. (On-line Medical Dictionary)
C17241	Urinalysis	Test|Test_Generic	Urinalysis|urinalysis	A test that determines the content of the urine.
C17242	Urokinase	Plasminogen_Activator	Urokinase|PLAU|Plasminogen Activator, Urinary|Plasminogen Activator, Urokinase|U-Plasminogen Activator|Urinary Plasminogen Activator|Urokinase Plasminogen Activator|Urokinase-Type Plasminogen Activator|u-PA|uPA	A drug that dissolves blood clots or prevents them from forming.
C17243	Urology	Medical_Specialty|Surgical_Specialty	Urology|UROL	The medical specialty concerned with the study, diagnosis, and treatment of diseases of the genitourinary tract.
C17244	Uruguay	Country	Uruguay|858|URY|UY	A country in Southern South America, bordering the South Atlantic Ocean, between Argentina and Brazil. (CIA World Factbook 2002)
C17245	E-Cadherin	Cadherin	E-Cadherin|CAM 120/80|CDH1|Cadherin-1|Epithelial Calcium-Dependent Adhesion Protein|Epithelial-Cadherin|Uvomorulin	Encoded by human CDH1 Gene (CDH Family), 882-amino acid 97 kD (precursor) invasion suppressor type I membrane protein E-Cadherin is the main homodimeric Ca(2+)-dependent cell-cell adhesion glycoprotein in non-neural epithelia. Structurally similar to immunoglobulins, E-cadherin contains five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail required for internalization. E-Cadherin acts as ligand for integrin Alpha-E/Beta-7. CDH1 defects cause Familial Gastric Cancer. CDH1 mutations are correlated with breast, colorectal, thyroid, and ovarian cancer. E-cadherin down regulation often correlates with invasive potential and poor prognosis of human carcinomas; it is likely a main event in cancer proliferation, invasion, and metastasis, due to dysfunction of cell-cell adhesion. (from LocusLink, SWISS-PROT, OMIM, and NCI)
C17246	Uzbekistan	Country	Uzbekistan|860|UZ|UZB	A country in Central Asia, north of Afghanistan. (CIA World Factbook 2002)
C17247	Vanuatu	Country	Vanuatu|548|NH|VU|VUT	A group of islands in the South Pacific Ocean, about three-quarters of the way from Hawaii to Australia. (CIA World Factbook 2002)
C17248	Genetic_Variation	Miscellaneous_Molecular_Biology_Terms	Genetic Variation|Genetic Diversity|Sequence Variant|Sequence Variation	Genetic Variation consists of deviation(s) in the nucleotide sequence of the genetic material of an individual from that typical of the group to which the individual belongs, or deviation(s) in the nucleotide sequence of the genetic material of offspring from that of its parents.
C17249	Vatican_City	Country	Holy See|336|VA|VAT|VT|Vatican City	An enclave of Rome (Italy). (CIA World Factbook 2002)
C17250	Venezuela	Country	Venezuela|862|VE|VEN	A country in Northern South America, bordering the Caribbean Sea and the North Atlantic Ocean, between Colombia and Guyana. (CIA World Factbook 2002)
C17251	Veterinary_Medicine	Medicine	Veterinary Medicine	The practice of medicine as applied to non-human animals.
C17252	Vietnam	Country	Vietnam|704|VM|VN|VNM	A country in Southeastern Asia, bordering the Gulf of Thailand, Gulf of Tonkin, and South China Sea, alongside China, Laos, and Cambodia. (CIA World Factbook 2002)
C17253	Viral_Genome	Genome	Viral Genome
C17254	Viral_Protein	Non-Human_Protein	Viral Protein|Virus Protein	Proteins found in any species of virus.
C17255	United_States_Virgin_Islands	Country	United States Virgin Islands|850|VI|VIR|VQ|Virgin Islands	Islands between the Caribbean Sea and the North Atlantic Ocean, east of Puerto Rico. (CIA World Factbook 2002)
C17256	Virology	Microbiology	Virology
C17257	Visual_Perception	Perception	Visual Perception	The selecting and organizing of visual stimuli based on the individual's past experience.
C17258	Vital_Statistics	Demographics	Vital Statistics
C17259	Wallis_and_Futuna_Islands	Country	Wallis and Futuna Islands|876|WF|WLF	Islands in the South Pacific Ocean, about two-thirds of the way from Hawaii to New Zealand. (CIA World Factbook 2002)
C17260	Wound_Repair	Regeneration	Wound Repair|Wound Healing	Restoration of diseased or damaged tissues naturally by healing processes or artificially, as by surgical means.
C17261	Diagnostic_Radiology	Procedure	Diagnostic Radiology|Conventional X-Ray|Medical Imaging, X-Ray|X-Ray|X-Ray Imaging|XR	Examination of any part of the body for diagnostic purposes by means of various medical imaging modalities such as ionizing radiation, radionuclides, nuclear magnetic resonance, and ultrasound. Some of the methods produce an image of the anatomy; others (most of the nuclear medicine techniques) produce an image of functionality. The concept encompasses among other methods: conventional X-ray, computer tomography, single photon emission computed tomography, positron emission tomography.
C17262	X-Ray	Ionizing_Radiation	X-Ray|Gamma-Radiation|Radiation, X-Rays|X-radiation|x-ray	A type of high-energy radiation.  In low doses, x-rays are used to diagnose diseases by making pictures of the inside of the body.  In high doses, x-rays are used to treat cancer.
C17263	Xeroradiography	Diagnostic_Radiology	Xeroradiography|xeroradiography	(ZEE-ro-ray-dee-AH-gra-fee) A type of x-ray in which a picture of the body is recorded on paper rather than on film.
C17264	Yemen	Country	Yemen|887|YE|YEM|YM	A country in the Middle East, bordering the Arabian Sea, Gulf of Aden, and Red Sea, between Oman and Saudi Arabia. (CIA World Factbook 2002)
C17265	Serbia_and_Montenegro	Country	Serbia and Montenegro|891|CS|Federation Republic of Yugoslavia|SCG|YI|Yugoslavia	A republic in Southeastern Europe, bordering the Adriatic Sea, between Albania and Bosnia and Herzegovina. Formerly known as Yugoslavia.  (CIA World Factbook 2002)
C17266	Democratic_Republic_of_the_Congo	Country	Democratic Republic of the Congo|180|CD|CG|COD|Zaire	A country in Central Africa, northeast of Angola. (CIA World Factbook 2002)
C17267	Zambia	Country	Zambia|894|ZA|ZM|ZMB	A country in Southern Africa, east of Angola. (CIA World Factbook 2002)
C17268	Zimbabwe	Country	Zimbabwe|716|ZI|ZW|ZWE	A country in Southern Africa, between South Africa and Zambia. (CIA World Factbook 2002)
C17269	Zoology	Biology	Zoology	The branch of biology dealing with the study of animals.
C17270	Phosphatidylinositol-3_Kinase	Kinase	Phosphatidylinositol 3 Kinase|1-Phosphatidylinositol 3-Kinase|EC 2.7.1.153|PI 3 Kinase|PI3 Kinase|PI3-Kinase|Type I Phosphatidylinositol Kinase|Type III Phosphoinositide 3-Kinase	An enzyme that catalyzes the conversion of phosphatidylinositol to phosphatidylinositol 3-phosphate. This is the first committed step in the biosynthesis of phosphatidylinositol 3,4-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. This pathway is thought to play a critical role in DNA repair, V(D)J recombination and cell cycle checkpoints. (from LocusLink)
C17271	Amino_Acid_Transporter	Transport_Protein	Amino Acid Transporter|Amino Acid Channel	Amino Acid Transporter proteins carry organic compounds containing an amino (-NH2) and a carboxyl (-COOH) group through solubility barriers, such as aqueous body fluids, lipid membranes or across epithelial layers. After binding substrate, transmembrane transporters often undergo an energy-dependent conformational change that moves the substrate across the membrane with (symport) or against (antiport) concentration gradients.
C17272	Thrombin-Antithrombin_Complex	Protein_or_Riboprotein_Complex	Thrombin-Antithrombin Complex	A protease involved in clotting
C17273	Aryl_Hydrocarbon_Receptor	Transcription_Factor	Aryl Hydrocarbon Receptor|AH Receptor|AHR|Dioxin Receptor, Nuclear Translocator|Nuclear Translocator	The aryl hydrocarbon receptor (AhR) is a ligand-activated helix/loop/helix transcription factor found in a variety of vertebrate species. Many foreign planar aromatic compounds, such as polycyclic aromatic compounds and halogenated aromatic compounds such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) are ligands of AhR. Unlike the steroid/thyroid hormone receptors, there is no known physiological ligand for the AhR.
C17274	Bone_Morphogenetic_Protein	Transforming_Growth_Factor-Beta	Bone Morphogenetic Protein	Encoded by Bone Morphogenetic Protein Genes (TGF Beta Superfamily), 9 structurally related Bone Morphogenetic Proteins are non-collagenous bone-growth regulatory factors synthesized as large precursor molecules that are cleaved by proteolytic enzymes and form an active homodimer or heterodimer of two related bone morphogenetic proteins that stimulate osteogenesis. (NCI)
C17275	Calcineurin	Protein_or_Riboprotein_Complex	Calcineurin	Ubiquitous heterodimeric human Calcineurin is Ca(2+)/calmodulin-regulated protein phosphatase involved in many biologic activities as a modifier of phosphorylation status. Composed of widely expressed or tissue-restricted 55-60-kDa calmodulin-binding catalytic subunit (PPP Phosphatase/PP-2B Family) and conserved 19-kD Ca(2+)-sensitive regulatory subunit, Calcineurin appears to regulate glycolytic metabolism, nuclear translocation of NFATC1 transcription factor, sperm motility, and dopaminergic signal transduction and NMDA receptor-dependent synaptic plasticity. (NCI)
C17276	Cathepsin-H	Cathepsin	Cathepsin H|Aleurain|CPSB|CTSH|CTSH Protein|Cathepsin B3|Cathepsin BA|EC 3.4.22.16|MGC1519|N-Benzoylarginine-Beta-Naphthylamide Hydrolase	This protein is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. (from LocusLink)
C17277	Cathepsin-L	Cathepsin	Cathepsin L|CATL|CTSL|CTSL Protein|EC 3.4.22.15|MEP|Major Excreted Protein	Cathepsin L, encoded by the CTSL Gene, is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. It is important for the overall degradation of proteins in lysosomes. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. Cathepsin L has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. Cathepsin L is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene. (From LocusLink and NCI)
C17278	Azurocidin	Immunoprotein	Azurocidin|AZAMP|AZU|AZU1|AZU1 Protein|Azurocidin 1|Azurocidin 1 (Cationic Antimicrobial Protein 37)|CAP37|Cationic Antimicrobial Protein 37|Cationic Antimicrobial Protein, 37kd|Cationic Antimicrobial Protein-37|HBP|Heparin Binding Protein|Heparin-Binding Protein|Humazur|NAZC|Neutrophil Azurocidin	A constitutively expressed protein in human neutrophils; a 29-kDa glycoprotein with broad spectrum antimicrobial activity and chemotactic activity toward monocytes
C17279	CD22_Antigen	Cell_Adhesion_Molecule	CD22 Antigen|B-Cell Antigen CD22|B-Lymphocyte Cell Adhesion Molecule|CD22|Lyb8|Sialic Acid-Binding Immunoglobulin-Like Lectin 2	B cell specific adhesion molecule; active in adhesion to monocytes and T cells.
C17280	CD34_Antigen	Cell_Adhesion_Molecule	CD34 Antigen|CD34|CD34 antigen|Hematopoietic Progenitor Cell Antigen CD34|gp105-120	A protein found on the surface of some bone marrow and blood cells.
C17281	CD40L_Receptor	TNF_Receptor_Family_Protein	Tumor Necrosis Factor Receptor Superfamily Member 5|B Cell-Associated Molecule CD40|CD40|CD40 Antigen|CD40 Type II Isoform|CD40L Receptor|Nerve Growth Factor Receptor-Related B-Lymphocyte Activation Molecule|TNFRSF5	50 kD glycoprotein expressed on all B cells; plays an important role in B cell development and activation.
C17282	Protein_Tyrosine_Phosphatase_Receptor_Type-C	Protein_Tyrosine_Phosphatase	Protein Tyrosine Phosphatase, Receptor Type, C|CD45|CD45 Antigen|Leukocyte Common Antigen|PTPRC|T200 Glycoprotein	This protein is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. It is specifically expressed in hematopoietic cells. It has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. It also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. (RefSeq)
C17283	Vitronectin	Cell_Adhesion_Molecule	Vitronectin|Complement S-Protein|Epibolin|Serum Spreading Factor|Somatomedin B|VTN	This protein is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. (LocusLink)
C17284	Chromogranin-A	Chromogranin	Chromogranin A|CHGA|CgA|Parathyroid Secretory Protein 1|Pituitary Secretory Protein I	A neuroendocrine product of certain prostate cells.  Adds to the predictive value of prostate specific antigen in the evaluation of men with prostate disease. (from Medscape)
C17285	CRE_Recombinase	Bacterial_Protein	CRE Recombinase	CRE Recombinase catalyses site-specific recombination between two 34 base pair loxp sites and maintains the phage genome as a monomeric unit-copy plasmid in the lysogenic state.  CRE is a homotetramer when bound to DNA and belongs to the phage integrase family.  (from SWISS-PROT P06956 and NCI)
C17286	cAMP_Responsive_Element_Binding_Protein	Transcription_Factor	cAMP Responsive Element Binding Protein|CRE Binding Protein|CREB|CREB Protein|Cyclic AMP Responsive Element Binding Protein	Ubiquitously or widely expressed human cAMP Responsive Element Binding Proteins (bZIP/CREB Family) are conserved nuclear bZIP domain dimeric transcription factors that bind to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induce gene transcription in response to cAMP signaling pathways. CREB proteins bind to DNA as a homodimer or a heterodimer with JUN/c-Jun or ATF2/CREBP1. Increased cAMP levels following stimulation activate cAMP-dependent protein kinase A, which phosphorylates CREB proteins that stimulate transcription of cAMP-responsive genes.  Calcium-regulated CREB transcription factors integrate calcium and cAMP signals.  cAMP pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals. (NCI)
C17287	Cytochrome-P450-2D6	Cytochrome-P450	Cytochrome P450 2D6|CYP2D6|CYPIID6|Cytochrome P450 Subfamily IID Polypeptide 6|Cytochrome P450, Subfamily IID|Cytochrome P450, Subfamily IID-Like 1|Debrisoquine 4-Hydroxylase|EC 1.14.14.1|Flavoprotein-Linked Monooxygenase|Microsomal Monooxygenase|P450-2D6|P450-DB1|P450DB1|Xenobiotic Monooxygenase	This protein is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 20% of commonly prescribed drugs. Its substrates include debrisoquine, an adrenergic-blocking drug; sparteine and propafenone, both anti-arrhythmic drugs; and amitriptyline, an anti-depressant. The gene is highly polymorphic in the population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. (from LocusLink)
C17288	dGTPase	Esterase	dGTPase	Deoxyguanosine triphosphate (dGTP) triphosphohydrolase (EC 3.1.5.1).  Highly specific for dGTP, producing deoxyguanosine and inorganic tripolyphosphate. (Seto et al, JBC 1988)
C17289	Dihydroorotate_Dehydrogenase	Oxidoreductase	Dihydroorotate Dehydrogenase|(S)-dihydroorotate:oxygen oxidoreductase|DHODH|DHOdehase|Dihydroorotate Oxidase|Dihydroorotic Acid Dehydrogenase|EC 1.3.3.1	A drug target in the pyrimidine biosynthetic pathway.  Variation in gene expression or sequence may alter the efficacy of chemotherapy.
C17290	Dihydropyrimidine_Dehydrogenase	Oxidoreductase	Dihydropyrimidine Dehydrogenase|DPD|DPYD|EC 1.3.1.2	An enzyme involved in pyrimidine catabolism. Increased DPD levels can influence tumor response to 5-fluorouracil-based chemotherapy through increased inactivation of the agent in tumor cells. Increases of the DPD mRNA level in cancerous tissue seem to reflect tumor progression. High DPD mRNA levels in liver metastasis and advanced colorectal cancer may have clinical importance for 5-fluorouracil-based chemosensitivity. (from Ann Surg Oncol 2002;9:599-603)
C17291	DNA_Primase	Protein_or_Riboprotein_Complex	DNA Primase|Primase	Heterodimeric human DNA Primase consists of a 49-kDa (small) and a 58-kDa (large) subunit. Eukaryotic DNA replication involves a replication apparatus containing the key enzymatic components DNA Primase and DNA Polymerase Alpha. DNA Primase is a polymerase that synthesizes small RNA primers for Okazaki fragments made during discontinuous DNA replication. (NCI)
C17292	Dopamine_Receptor-D2	Dopamine_Receptor	Dopamine Receptor D2|DRD2|DRD2 Receptor|Dopamine D2 Receptor	Neurotransmission mediated by the Dopamine D2 Receptor (DRD2) plays a key role in the control of movement, in reward and reinforcement mechanisms in psychiatric disorders, and in the neuromodulation of appetitive behaviors.  Acting through D2 dopamine receptors, dopamine specifically inhibits the vascular permeabilizing and angiogenic activities of VEGF by inducing endocytosis of VEGF receptor 2, preventing VEGF binding, receptor phosphorylation, and signaling.(from OMIM 126450 and NCI)
C17293	Vascular_Endothelial_Growth_Factor_Receptor	Growth_Factor_Receptor	Vascular Endothelial Growth Factor Receptor|Receptor, Vascular Endothelial Growth Factor|VEGFR	There are three signaling VEGF receptors. The VEGF family members PIGF and VEGF-B with exclusive binding capacities to the VEGFR-1 can influence monocyte activation and differentiation. The VEGFR-2 and VEGFR-3 binding VEGF homologues, VEGF-C and VEGF-D, are mitogens for both vascular and lymphatic endothelial cells. The orf virus encoded VEGF-E homologue binds and activates only the VEGFR-2 and thus may be the prototype of a vascular endothelial cell-specific growth factor.  Further specific activities of VEGF and its homologues result from receptor-specific signaling and differential expression of ligands or receptors. A naturally occurring soluble form of the VEGFR-1 suggests a regulatory role for this receptor.(Semin Thromb Hemost 2000;26(5):561-9)
C17294	Transcription_Factor-AP2_Alpha	AP-2_Family_Transcription_Factor	Transcription Factor AP-2 Alpha|AP-2|AP-2 Alpha|AP-2 Alpha Protein|AP2|AP2 Protein|AP2 Transcription Factor|AP2TF Protein|Activating Enhancer-Binding Protein 2-Alpha|Activator Protein 2|TFAP2 Protein|TFAP2A|TFAP2A Protein	A 52-kDa, positive DNA-binding transcription factor that interacts with viral and cellular enhancers. AP-2 appears to regulate ectodermal development.
C17295	Erythropoietin_Receptor	Colony_Stimulating_Factor_Receptor	Erythropoietin Receptor|EPO-R|EPOR	Human erythropoietin receptor protein (508 aa, 55 kDa precursor) is encoded by the human erythropoietin receptor (EPOR) gene. Erythropoietin receptor is a cell surface receptor that binds erythropoietin with high affinity and activates the JAK2 tyrosine kinase pathway.
C17296	Cytochrome-P450-1A1	Cytochrome-P450	Cytochrome P450 1A1|Aryl Hydrocarbon Hydroxylase|CYP1A1|CYP1A1 Product|Cytochrome P1-450, Dioxin-Inducible|Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1|EC 1.14.14.1|Flavoprotein-Linked Monooxygenase|Microsomal Monooxygenase|P450 Form 6|P450-1A1|P450-C|P450-P1	A cytochrome P-450 enzyme capable of activating procarcinogenic polycyclic hydrocarbons and halogenated aromatic hydrocarbons into mutagenic compounds. Ethoxyresorufin acts as a substrate for CYP1A1 and measurement of ethoxyresorufin O-deethylase provides a more direct method of detection for this enzyme. EC 1.-.
C17297	Fibroblast_Growth_Factor_Receptor_Family	Growth_Factor_Receptor	Fibroblast Growth Factor Receptor Family|FGF Receptor|FGF-R|FGFR	Family of receptor tyrosine kinases for fibroblast growth factor. Amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. (On-line Medical Dictionary and RefSeq)
C17298	GTPase-Activating_Protein	Signaling_Protein	GTPase-Activating Protein|GAP	An extensive family of proteins that stimulates the GTPase activity of GTP-binding ras proteins.
C17299	Haptoglobin-Related_Protein	Protein_with_Unknown_or_Unclassified_Function	Haptoglobin-Related Protein|HPR	Haptoglobin-related protein (trypanosome lytic factor) confers human resistance to Trypanosome brucei.  HPR or HPR-like epitopes are expressed in human breast carcinoma.  Expression of HPR epitopes was associated with earlier recurrence, and multivariate analysis showed that HPR-epitope expression was an independent prognostic factor.
C17300	Heparan_Sulfate_Proteoglycan	Extracellular_Matrix_Protein	Heparan Sulfate Proteoglycan|HSPG	Heparan Sulfate Proteoglycan is an extracellular matrix and vascular basal lamina component. Heparan Sulfate is also an essential co-factor in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions.  Degradation by heparanase is a key step in extravasation by tumor cells and migrating leukocytes, as well as in angiogenesis, wound healing, and smooth muscle proliferation. Degradation by heparanase is a key step in extravasation by tumor cells and migrating leukocytes, as well as in angiogenesis, wound healing, and smooth muscle proliferation. In basement membranes, heparan sulfate may stabilize other molecules and influence glomerular permeability and cell adhesion. (From OMIM 142461 and NCI)
C17301	Heparinase	Bacterial_Protein	Heparinase	Eliminative cleavage of polysaccharides containing 1,4-linked D-glucuronate or L-iduronate residues and 1,4-a-linked 2-sulfoamino-2-deoxy-6-sulfo-D-glucose residues to give oligosaccharides with terminal 4-deoxy-a-D-gluc-4-enuronosyl groups at their non-reducing ends. (IUBMB Enzyme Nomenclature)
C17302	Histone_Acetylase	Acyltransferase	Histone Acetylase|EC 2.3.1.48|HAT|Histone Acetyltransferase	Class of enzymes that catalyze the acetylation of specific lysine residues of histones, proteins that organize eukaryotic DNA into chromatin.  Among the proteins that exhibit histone acetyltransferase activity are various transcription factor coactivators.  E.C. 2.3.1.48.
C17303	Integrase	Viral_Protein	Integrase	Integrase is an enzyme that catalyzes the integration of viral DNA into the host genome. This protein is encoded by the retroviral and bacteriophage pol gene. It acts to covalently link viral DNA to host DNA.
C17304	Intercellular_Adhesion_Molecule-1	Cell_Adhesion_Molecule	Intercellular Adhesion Molecule 1|CD54|ICAM-1|ICAM1|Intercellular Adhesion Molecule-1	LFA-1 is a receptor for ICAM1, a surface molecule constitutively expressed on some tissues and induced on others in inflammation.  The interaction of LFA-1 with ICAM provides essential accessory adhesion signals in many immune interactions, including those between T- and B-lymphocytes and cytotoxic T-cells and their targets.
C17305	Ku_Protein	Helicase	Ku Protein|ATP-dependent DNA helicase II	Encoded by Ku Subunit Genes, tightly-associated 70-kDa Ku70 Protein and 80-kDa Ku80 Protein are subunits of heterodimeric DNA-binding Ku Protein, a DNA damage repair complex that, with the 470-kDa catalytic DNA-PKcs subunit forms DNA-dependent protein kinase, binds and repairs double-stranded DNA breaks, facilitates repair by nonhomologous end-joining, and is involved in V(D)J recombination. Ku also binds to DNA ends with a telomere binding protein and mediates telomere capping to prevent fusion of chromosome ends and genetic instability. KU70 and KU80 form a dyad-symmetrical ring molecule that encircles duplex DNA. Ku is identical to DNA helicase II, an ATP-dependent DNA unwinding enzyme. (NCI)
C17306	Laminin_Receptor-1	Cell_Surface_Receptor|Ribosomal_Protein	Laminin Receptor-1|34/67 kD Laminin Receptor|37LRP|40S Ribosomal Protein SA|67LR|67kD Laminin Receptor|67kD, Ribosomal Protein SA|Colon Carcinoma Laminin-Binding Protein|LAMR1|LAMR1 Protein|Laminin Receptor|Laminin Receptor 1|Laminin Receptor 1 (67kD, Ribosomal Protein SA)|Laminin Receptor 1 (Ribosomal Protein SA, 67kD)|Laminin Receptor, 67-kD|Laminin Receptor-1 (67kD)|Laminin Receptor-1, 40S Ribosomal Protein SA|Multidrug Resistance-Associated Protein MGR1-AG|NEM/1CHD4|Ribosomal Protein SA|p40|p40 Ribosome-Associated Protein	Encoded by human LAMR1 Gene (Non-Integrin Family, S2P Family), this 295-amino acid 37-kD protein contains a negative C-terminal segment, amphipathic alpha-helices, and N-glycosylation sites. Identical to 40S Ribosomal Protein SA, the heterodimeric 67-kD Laminin Receptor-1 is a conserved multifunctional protein involved in translation and cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis. Expression in cancer cells correlates with invasive/metastatic phenotype.  (from LocusLink, Swiss-Prot, OMIM, and NCI)
C17307	Lamin	Intermediate_Filament_Protein	Lamin|Type V IF Protein	The Type V intermediate filaments have a nuclear signal sequence and form a filamentous support inside the inner nuclear membrane. Their assembly and disassembly into the lamina is controlled through the cell cycle by phosphorylation and interactions with additional proteins and nuclear structures. Lamins are vital to the re-formation of the nuclear envelope after cell division and vital to the re-formation of the nuclear envelope after cell division.
C17308	CD18_Antigen	Retired_Concepts	CD18 Antigen|Beta 2 Integrin Chain|CD11a Beta Subunit|CD11b Beta Subunit|CD11c Beta Subunit|ITGB2|Integrin Beta-2|Lymphocyte Function-Associated Cell Surface Adhesion Glycoprotein
C17309	p56-LCK	SRC_Family_Tyrosine_Kinase	p56-LCK|EC 2.7.1.112|LCK|LSK|Lymphocyte-Specific Protein Tyrosine Kinase|Lymphocyte-Specific Protein-Tyrosine Kinase|Lymphocyte-Specific p56LCK Tyrosine Protein Kinase|P56-LCK|Proto-Oncogene Tyrosine-Protein Kinase LCK|T Cell-Specific Protein-Tyrosine Kinase|T-Cell Specific Protein Tyrosine Kinase	A protein tyrosine kinase activated within seconds after crosslinking the mIg complex on B cells or the TCR on T cells.
C17310	Melatonin_Receptor	G_Protein-Coupled_Receptor	Melatonin Receptor	Members of the G protein-coupled superfamily of receptors.  Two pharmacologically distinct high affinity melatonin receptors have been identified, Mel1 and Mel2, and Mel1 class receptors Mel1A, Mel1B, and Mel1C have been cloned.  Transduce signals via at least two pathways, one inhibiting adenylyl cyclase and the other regulating phospholipide metabolism and calcium concentration.
C17311	Methylenetetrahydrofolate_Reductase	Oxidoreductase	Methylenetetrahydrofolate Reductase|5-methyltetrahydrofolate:NADP oxidoreductase|EC 1.5.1.20|MTHFR|Methylenetetrahydrofolate Reductase (NADPH)	A flavoprotein (FAD).  [EC 1.5.1.20 created 1978 as EC 1.1.1.171, transferred 1984 to EC 1.5.1.20] (from IUBMB).
C17312	Mineralocorticoid_Receptor	Steroid_Hormone_Receptor	Mineralocorticoid Receptor|Aldosterone Receptor|MCR|MLR|MR|NR3C2|Nuclear Receptor Subfamily 3 Group C Member 2|Receptors, Mineralocorticoid	Highly expressed as 4 alternative isoforms in kidney and sweat glands by human NR3C2 Gene (NR3 Family), ubiquitous phosphorylated Mineralocorticoid Receptor contains an N-terminal modulating domain, a DNA-binding domain, and a C-terminal steroid (mineralocorticoid/glucocorticoid)-binding domain. Absent ligand, NR3C2 resides in a heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4 or with HSD11B2 in the ER membrane. Ligand-activated NR3C2 translocates to the nucleus, binds to DNA mineralocorticoid response elements as a homodimer or heterodimer with NR3C1, and transactivates target gene expression, which increases ion and water transport; raises extracellular fluid volume and blood pressure; and lowers potassium levels. NR3C2 appears to bind NCOA1, NCOA2, TIF1, and NRIP1. NR3C2 defects cause PHA1 and early onset hypertension. (NCI)
C17313	Melanoma_Adhesion_Molecule	Protein_with_Unknown_or_Unclassified_Function	Melanoma Adhesion Molecule|A32|CD146 Antigen|MCAM|MUC18 Glycoprotein|Mel-CAM|Melanoma Cell Adhesive Molecule|S-Endo	Active in neural crest cells during development and expressed primarily in neuroectodermal lineages and vascular smooth muscle in adult tissues by human MCAM Gene (Ig Superfamily), 646-aa 72-kDa (precursor) Melanoma Adhesion Molecule is a cell surface type I membrane glycoprotein containing 3 Ig-like C2-type domains and 2 Ig-like V-type domains and a possible adhesion molecule homologue of cell adhesion molecule NCAM. (NCI)
C17314	Nucleoside_Diphosphate_Kinase-A	Kinase	Nucleoside Diphosphate Kinase A|EC 2.7.4.6|Metastasis Inhibition Factor NM23|NDKA|NDP Kinase A|NM23 Gene Product|p19-NM23	Nucleoside Diphosphate Kinase A (NM23) activity is correlated with inhibition of metastasis; low NM23 levels are associated with high metastatic potential.  NM23 has sequence homology with the developmentally related Drosophila awd protein.  NM23 may be a transcription factor for the MYC oncogene.  PuF (NM23) binds to a nuclease-hypersensitive element of the MYC P1 promoter and is necessary for efficient P1 and P2 transcription initiation.  A murine homologue of NM23 is a differentiation inhibiting factor in myeloid cells.  (from OMIM 156490 and NCI)
C17315	O-6-Methylguanine-DNA_Methyltransferase	Methyltransferase	O-6-Methylguanine-DNA Methyltransferase|AGT|Alkylguanine DNA Alkyltransferase|DNA-6-O-Methylguanine[protein]-L-Cysteine S-Methyltransferase|EC 2.1.1.63|MGMT|Methylated-DNA Protein-Cysteine Methyltransferase|Methylguanine-DNA Methyltransferase|O6-Alkylguanine DNA Alkyltransferase	Encoded by human MGMT Gene (MGMT Family), 207-aa 22-kDa O-6-Methylguanine-DNA Methyltransferase is a unique and ubiquitous DNA repair enzyme that acts on alkylated guanine and other methylated DNA moieties. O(6)-alkylguanine is the major mutagenic and carcinogenic adduct lesion in DNA, induced by simple alkylating mutagens because of its preference for pairing with thymine during DNA replication. Unlike true enzymes, MGMT accepts the O-6 alkyl group from the lesion to a cysteine acceptor residue in the enzyme repairing the alkylated DNA in a stoichiometric second-order suicide reaction; the enzyme is irreversibly inactivated. (NCI)
C17316	DBL_Oncoprotein	MCF2_p66_Protein	DBL Oncoprotein|p66	Human DBL Oncoprotein is product of a mutated variant (Oncogene DBL) of widely expressed MCF2 Gene, which encodes 4 alternative variants of 66-kDa MCF2 (DBL) p66 Protein, a cytoplasmic and membrane phosphoserine guanine nucleotide exchange factor that modulates the activity of small RHO GTPases by promoting conversion from GDP- to GTP-bound form. p66 contains a CRAL-TRIO domain, a DH domain, a PH domain and a spectrin repeat; the DH domain catalyzes GDP-GTP exchange. Activated DBL oncogene is generated by 5-prime recombination with 3 (pter-p21) and by 3-prime recombination with 16 (p13-q22). The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42. DBL Oncoprotein disrupts normal cell function.
C17317	Papillomavirus_Type_16_Protein-E2	Papillomavirus_Protein-E2	Oncogene Protein E2, Human Papilloma Virus Type 16
C17318	Papillomavirus_Type_1_Protein-E4	Papillomavirus_Protein-E4	Oncogene Protein E4, Human Papilloma Virus Type 1
C17319	ERBB2_Receptor_Protein-Tyrosine_Kinase	ERBB2_Protein	ERBB2 Receptor Protein-Tyrosine Kinase|ERBB2|HER-2|HER2|NEU|c-erbB-2	The ERBB2 gene encodes a putative tyrosine kinase growth factor receptor EGFR2, p185 HER2/NEU antigen, similar to the EGF receptor.  The ERBB2, ERBB3, and ERBB4 genes encode heregulin/neuregulin receptors, members of the EGFR-related type I receptor tyrosine kinase subfamily.  The encoded proteins form homo- and heterodimers, which complicates assignment of function: ERBB2 homodimers do not bind heregulin, but ERBB2/ERBB3 heterodimers do.  Herstatin is a secreted alternative ERBB2 product, of the extracellular domain, that binds to p185ERBB2, disrupts ERBB2 dimers, reduces p185 phosphorylation, and inhibits growth.  Human ERBB2 gene is located at 17p12-21.  Overexpression of HER-2 correlates with poor prognosis in breast carcinoma.
C17320	Myb_Oncogene_Protein	c-Myb_Protein	Myb Oncogene Protein	Human MYB Oncogene Protein is a product of a mutated variant (Oncogene MYB) of MYB Gene, which encodes 6 alternative isoforms of 640 aa 72-kDa nuclear c-MYB protein, a DNA-binding transcriptional activator critical for hematopoietic progenitor cell proliferation and differentiation. MYB contains 3 N-terminal MYB-like DNA-binding domains that specifically recognize YAAC[GT]G, a central transcriptional activation domain and a C-terminal transcriptional repression domain. MYB may interact with HIPK2 and NLK; phosphorylation by NLK on multiple sites may induce proteasomal degradation. Ubiquitination may be mediated by SIAH1. MYB Oncogene Protein disrupts normal cell function.
C17321	Urokinase_Receptor	Cell_Surface_Receptor	Urokinase Receptor|CD87|Plasminogen Activator, Urokinase Receptor|Urokinase Plasminogen Activator Receptor|Urokinase-type Plasminogen Activator Receptor|uPAR	High affinity cellular receptor for urokinase plasminogen activator (uPA).  Plays a role in plasminogen activation by facilitating the conversion of uPA to an enzymatically active form anchored to the cell membrane, where plasminogen activation occurs.  Affects tissue remodeling (surface proteolysis, cell adhesion, cell migration), and cancer invasion.
C17322	Platelet-Derived_Growth_Factor_Receptor	Growth_Factor_Receptor	Platelet-Derived Growth Factor Receptor|PDGF Receptor|PDGFR	A cell surface protein that has tyrosine-kinase activity. This receptor specifically binds to platelet derived growth factor, and its analogs and antagonists. Ligand binding causes homodimerization or heterodimerization, resulting in receptor activation.
C17323	Proliferating_Cell_Nuclear_Antigen	Cell_Cycle_Protein	Proliferating Cell Nuclear Antigen|Cyclin|DNA Polymerase Delta Auxiliary Protein|PCNA	This protein is found in the nucleus and is a cofactor of DNA polymerase delta. It acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. (from LocusLink)
C17324	Plasminogen_Activator_Inhibitor-3	Plasminogen_Activator_Inhibitor	Plasminogen Activator Inhibitor-3|Acrosomal Serine Protease Inhibitor|Alpha-1 Antiproteinase|Antitrypsin|PAI-3|PCI|PLANH3|PROCI|Plasma Serine Protease Inhibitor|Plasminogen Activator Inhibitor III|Protein C Inhibitor|SERPINA5|Serine or Cysteine Proteinase Inhibitor Clade A Member 5	A member of the serpin family of proteins that is found in plasma and urine. It is dependent on heparin and able to inhibit activated protein C, thrombin, kallikrein, and other serine proteinases. (MSH99)
C17325	Serine-Threonine_Protein_Kinase	Protein_Kinase	Serine/Threonine Protein Kinase|EC 2.7.1.37|Serine-Threonine Protein Kinase	A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
C17326	p53-LYN_Protein	SRC_Family_Tyrosine_Kinase	p56LYN|LYN|p53 LYN|p53-LYN|p56 LYN|p56-LYN	aka p53/56LYN.  A protein tyrosine kinase activated within seconds after crosslinking the mIg complex on B cells.
C17327	MOS-pp39_Serine-Threonine_Kinase	Serine-Threonine_Protein_Kinase	MOS pp39 Serine/Threonine Kinase|C-MOS|MOS|MOS Protein	Cellular proteins encoded by the c-mos genes (GENES, MOS). They function in the cell cycle to maintain MATURATION PROMOTING FACTOR in the active state and have protein-serine/threonine kinase activity. Oncogenic transformation can take place when c-mos proteins are expressed at the wrong time.
C17328	Stem_Cell_Factor_Receptor	Receptor_Tyrosine_Kinase	Stem Cell Factor Receptor|C-KIT|CD117|EC 2.7.1.112|KIT|Mast Cell Growth Factor Receptor|SCF Receptor|c-kit receptor	A protein on the surface of some cells that binds to stem cell factor (a substance that causes certain types of cells to grow).  Altered forms of this receptor may be associated with some types of cancer.
C17329	c-Myb_Protein	Transcription_Factor	c-Myb Protein|MYB|c-Myb	Encoded by human MYB Gene as 6 alternative isoforms, 640 aa 72-kDa nuclear c-MYB protein is a DNA-binding transcriptional activator critical for hematopoietic progenitor cell proliferation and differentiation. MYB contains 3 N-terminal MYB-like DNA-binding domains that specifically recognize YAAC[GT]G, a central transcriptional activation domain and a C-terminal transcriptional repression domain. MYB may interact with HIPK2 and NLK; phosphorylation by NLK on multiple sites may induce proteasomal degradation. Ubiquitination may be mediated by SIAH1.
C17330	PS2_Protein	Regulatory_Protein	PS2 Protein|Breast Cancer Estrogen-Inducible Protein|Gastrointestinal Trefoil Protein PS2|PS2|TFF1|Trefoil Factor 1|Trefoil Protein 1	Expressed in breast, pancreas, stomach, and gastrointestinal epithelium, estrogen-responsive human TFF1 Gene (Trefoil Family) encodes cysteine-rich secretory 84-aa 9-kD (precursor) PS2 Protein, a likely tumor suppressor containing one P-type trefoil domain and a 40-aa domain with three conserved disulfides. TFF1 appears to play a complex repressor role in cell progression towards S phase (G1/S transition) and in apoptosis; TFF1 may promote cell differentiation and tissue repair. TFF1 may protect the gastrointestinal mucosa from insults, stabilize the mucus layer, and affect epithelial healing; strong expression is found in GI tract regenerative tissues. The exact function of TFF1/PS2 has not yet been determined. (NCI)
C17331	RHOB_Protein	RAS_Superfamily_Protein	RHOB Protein|ARHB|H6|Transforming Protein RHOB	RHO B protein is a GTP-binding protein involved in a signal transduction pathway that controls assembly of focal adhesions and actin stress fibers.  Rho regulates remodeling of the actin cytoskeleton during cell morphogenesis and motility.  Active Rho signals to its downstream effector ROCK1, which phosphorylates and activates LIM kinase.  LIM kinase, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.  (from OMIM 165370 and NCI)
C17332	Insulin-Like_Growth_Factor-Binding_Protein	Ligand_Binding_Protein	Insulin-Like Growth Factor-Binding Protein|IGFBP	A family of soluble proteins that bind insulin-like growth factors and modulate their biological actions at the cellular level.  Serum IGFBP levels have been found to be negatively correlated to the risk of cancer.
C17333	Somatostatin_Receptor	Protein_Hormone_Receptor	Somatostatin Receptor	Cell surface proteins that bind somatostatin and trigger intracellular changes which influence the behavior of cells. Somatostatin receptor scintigraphy has been one of the most important diagnostic tools for staging of Neuroendocrine gastrointestinal tumors and also indicating sensitivity to treatment with somatostatin analogues.  This marker can be used for diagnosis and follow-up of the patients. (from Ann Oncol 1999;10 Suppl 2:S3-8)
C17334	Streptavidin	Ligand_Binding_Protein	Streptavidin|streptavidin	A small bacterial protein that binds with high affinity to the vitamin biotin. This streptavidin-biotin combination can be used to link molecules such as radioisotopes and monoclonal antibodies together. These bound products have the property of being attracted to, and attaching to, cancer cells, rather than normal cells. The radiolabeled products are more easily removed from the body, thus decreasing their toxicity.
C17335	Syndecans	Transmembrane_Protein	Syndecans	The syndecans are a family of cell-surface heparan sulphate proteoglycans that regulate cell behavior by binding extracellular matrix molecules such as growth factors. The syndecan family has four members, of which syndecan-1 is the most studied and best characterized.  In squamous cell carcinoma of the head and neck low syndecan-1 expression has been associated with unfavorable overall survival and can be used as a prognostic factor.
C17336	CD28_Antigen	Cell_Adhesion_Molecule	CD28 Antigen|CD28|T-Cell Antigen CD28|T90/44|Tp44	CD28 encodes a highly glycosylated membrane protein with homology to the Ig superfamily.  It also shares significant sequence identity with CTLA-4.  Both bind the same ligands, however CTLA-4 binds to B7 with a greater affinity.  B7 antigen-presenting cells regulate T-cell activation by delivering antigen-independent stimulatory signals through CD28 and inhibitory signals through CTLA-4.  CD28 is found on the membrane of resting T-cells.  Posttranslational processing appears to result in variant isotypes of CD28 with potentially different physiologic roles on the cell surface.  CD28 undergoes tyrosine phosphorylation after interacting with its ligand, B7.  Phosphorylation in the cytoplasmic domain of CD28 allows the recruitment of signaling proteins such as PI3K, GRB2, and GADS via their SH2 domains.  (from OMIM 186760 and NCI)
C17337	Taq_Polymerase	Bacterial_Protein	Taq Polymerase	A heat stable DNA-directed DNA polymerase. The enzyme is widely utilized in laboratory polymerase chain reaction applications.
C17338	Tenascin-C	Cell_Adhesion_Molecule|Extracellular_Matrix_Protein	Tenascin C|Cytotacin|Hexabrachion|TNC|Tenacin	Tenascin (hexabrachion, cytotactin) is an extracellular matrix protein that promotes cell attachment with spatially and temporally restricted tissue distribution in many developing organs.  It is a hexameric, multidomain protein with disulfide-linked subunits.  A C-terminal domain is similar to fibrinogen.  Tenascin also contains type III units, similar to those in fibronectin, and EGF-like repeats.  In the CNS, tenascin C is expressed primarily by astrocytes.  Tenascin expression is induced by serum as well as TGF-beta.  (from OMIM 187380 and NCI)
C17339	Thrombospondin	Angiogenesis_Inhibitory_Protein	Thrombospondin|TSP	A glycoprotein that is incorporated into cells, including blood platelets (thrombocytes) from which they are named. Five distinct forms have been identified, and they play roles in a variety of processes such as: blood coagulation, cell adhesion, platelet aggregation, cell proliferation, angiogenesis, tumor metastasis, and tissue repair.
C17340	Topoisomerase-III	Topoisomerase	Topoisomerase III|DNA Topoisomerase III|Topo III	Topoisomerase III belongs to type IA topoisomerases subfamily (includes archaebacterial reverse gyrase, bacterial topo I and topo III, which all form covalent 5'phosphotyrosine linkage with cleaved DNA).  Topo III does not play a major role in regulating DNA supercoiling, however, genetic experiments implicate that it plays a role in suppressing mitotic recombination and in resolving recombined homologous chromosomes during meiosis I. Topo III also has been demonstrated to interact with RecQ family of DNA helicases, which includes the Bloom's syndrome, Werner's syndrome, and Rothmund-Thomson syndrome gene products.
C17341	Transforming_Growth_Factor_Beta_Receptor_II	Receptor_Serine-Threonine_Kinase	Transforming Growth Factor Beta Receptor II|TGF B Receptor|TGF-Beta Type II Receptor|TGFBR2|Transforming Growth Factor Beta Receptor	The cell surface binding proteins for tumor-derived growth factor- beta. There are three receptors, Type I and Type II together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta. Type III is a transmembrane proteoglycan with a large extracellular domain and a cytoplasmic domain that lacks an obvious signaling motif.
C17342	Nerve_Growth_Factor_Receptor	Growth_Factor_Receptor	Nerve Growth Factor Receptor|NGFR	Nerve growth factor receptor (NGFR) is also referred to as p75(NTR) due to its molecular mass and its ability to bind at low affinity not only NGF, but also other neurotrophins, including brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NTF3), and neurotrophin-4/5 (NTF5). NGFR was the first member of the large superfamily of tumor necrosis factor receptors. The identification of this superfamily helped elucidate some of the biologic functions of NGFR, including its ultimate involvement in the nuclear factor kappa-B (NFKB) and apoptosis pathways. As a monomer, NGFR binds NGF with low affinity. Higher affinity binding is achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1), TRKB (NTRK2), and TRKC (NTRK3). (OMIM)
C17343	Troponin-I	Microfilament_Protein	Troponin I	Troponin I, troponin T, and troponin C are the three closely associated subunits of the troponin complex of thin filaments in muscle.  The complex serves as a calcium-sensitive switch that regulates muscle contraction.  In the absence of calcium, Troponin I binds actin, inhibits actomyosin ATPase activity, and inhibits F-actin-myosin interactions.  The troponin I gene family comprises three isoforms: skeletal TNI-fast, skeletal TNI-slow, and TNI-cardiac.  (from OMIM 191044, 191043, 191042 and NCI)
C17344	Tumor_Necrosis_Factor_Receptor	Retired_Concepts	Tumor Necrosis Factor Receptor|TNF Receptor|TNFR
C17345	Vasopressin_Receptor	G_Protein-Coupled_Receptor	Vasopressin Receptor	Neurohypophyseal vasopressin is a cyclic nonapeptide involved in diverse actions, including the control of body fluid osmolality, blood volume, blood pressure, vascular tone, hepatic glycogenolysis, vascular smooth muscle and mesangial cell contraction, nephric antidiuresis, and platelet aggregation.  Vasopressin binds to three GPCR subtypes: V1A, V1B, and V2.  The V1A receptor is located in liver, vascular smooth muscle, brain, mesangial cells, and platelets.  It mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor, and glycogenolysis.  V1A and V1B activate PLC via Gq/11, which increases intracellular calcium.  Arginine VP modulates ACTH, beta-endorphin, and prolactin release, mediated by V1B.  V2 is expressed exclusively in the kidney and mediates the antidiuretic effect of arginine VP by activating adenylyl cyclase via interaction with Gs.  (from OMIM 600821, 600264, and NCI)
C17346	ABL1_Gene	Non-Receptor_Tyrosine_Kinase_Gene	ABL1 Gene|ABL1|Abelson Murine Leukemia Viral Oncogene Homolog 1|JTK7|c-Abl|v-Abl Abelson Murine Leukemia Viral Oncogene Homolog 1 Gene	The ABL1 gene (ABL family) at 9q34.1 encodes a ubiquitous 145 kD nuclear/cytoplasmic non-receptor protein tyrosine kinase implicated in cell differentiation, division, adhesion, and stress response. ABL1 plays a role in myeloid hematopoiesis. Alternatively spliced exon 1a specifies nuclear ABL1 that enhances target gene transcription. ABL nuclear activity is regulated by CDC2 phosphorylation and by RB1. RB inhibits the ABL kinase. ABL transactivates the p73 gene and phosphorylates the p73 substrate. Alternatively spliced exon 1b encodes myristylated, plasma membrane-associated ABL1. PEST phosphatases negatively regulate ABL and PSTPIP1 is an ABL substrate. The ABL SH3 domain negatively regulates its kinase activity. The N-terminus mediates autoregulation and its loss is oncogenic. Fused BCR-ABL oncogenes are responsible for CML, AML, and ALL. (NCI)
C17347	CD-ROM	Storage_Medium	CD-ROM|CD-ROM (Compact Disc-Read Only Memory)|Compact Disc-Read Only Memory	An optical disk storage system for computers on which data can be read or from which data can be retrieved but not entered or modified.
C17348	Pap_Smear	Cytology_Specimen_Collection_Procedure	Pap Smear|PAP|Pap Test|Pap smear|Pap test|Papanicolaou Test|Vaginal Smears	A sample of secretions and superficial cells of the uterine cervix and uterus; examined with a microscope to detect any abnormal cells.
C17349	Cyclin	Cell_Cycle_Protein	Cyclin|Cyclins	A non-enzymatic regulatory protein that is critical during the cell cycle. The cyclin family members complex with other proteins to modulate the protein kinase activity of the cell.
C17350	DNA_Fingerprinting	DNA_Analysis	DNA Fingerprinting	A procedure in which multilocus band patterns of a DNA sample are generated by digestion of the DNA with restriction enzymes followed by electrophoresis and visualization by hybridization with probes specific for repetitive sequences. In forensic medicine, the probes used are "core" sequences specific for simple tandem-repetitive sequences (MINISATELLITE REPEATS or VNTRs). The multilocus band patterns, known as DNA fingerprints, are evaluated for similarities with DNA from an individual (From MSH 2001).
C17351	Extracellular_Matrix_Protein	Structural_Protein	Extracellular Matrix Protein	Encoded by Extracellular Matrix Protein Genes, Extracellular Matrix Proteins are mostly fibrous proteins (e.g., Collagen, Elastin, Fibronectins, and Laminin) typically located in the Extracellular Matrix and commonly involved in cell attachment, cell movement, cell growth, morphogenesis, organogenesis, and tissue repair, architecture, and organization. (NCI)
C17352	Facility_Construction	Funding_Category	Facility Construction|Construction	4D; Clinical Health Services Research And Delivery; Research
C17353	Fluorescence_Activated_Cell_Sorting	Flow_Cytometry	Fluorescence Activated Cell Sorting|FACS|Fractionation, Fluorescence Activated Cell Sorting	Selection and deposition of individual cells of a particular phenotype from a mixed population into a separate tube or tissue culture plate by the use of a fluorescence-activated cell sorter (FACS) and fluorescently-labeled antibodies specific for surface molecules on the cells to be sorted.
C17354	Frameshift_Mutation	Gene_Mutation	Frameshift Mutation|Mutation, Frameshift|Reading Frame Shift Mutation	A type of mutation in which one or more paired nucleotides are inserted or deleted in the coding region of a gene, which causes the triplet codons to be read in the wrong frame; the resulting polypeptide has a garbled amino acid sequence from the mutated codon on. (BioTech Life Science Dictionary)
C17355	G1-Phase	Cell_Cycle_Stage	G1 Phase|G1|Gap 1 Phase	Phase of the cell cycle preceding DNA synthesis (Gap 1 phase). The subphases of G1 include competence, entry (G1a), progression (G1b), and assembly (G1c), based on the effects of limiting growth factors, nutrients, or inhibitors.
C17356	G2-Phase	Cell_Cycle_Stage	G2 Phase|G2|Gap 2 Phase	Phase of the cell cycle following DNA synthesis and preceding mitosis (Gap 2 phase). The chromosomes are tetraploid in this phase.
C17357	Gender	Personal_Attribute	Gender	The assemblage of properties that distinguish people on the basis of their societal roles.
C17358	DCC_Gene	Gene_with_Unknown_or_Unclassified_Function	DCC Gene|CRC18|Colorectal Cancer-Related Chromosome Sequence 18|DCC|Deleted in Colorectal Carcinoma|Deleted in Colorectal Carcinoma Gene	Isolated as a gene in a region frequently deleted in colorectal carcinomas, the DCC gene encodes a protein with sequence similarity to cell adhesion molecules such as N-CAM and may participate with other proteins in cell-cell and cell-matrix interactions. It is a transmembrane protein of the immunoglobulin superfamily, is expressed on spinal commissural axons and possesses netrin-1-binding activity. Knockout studies in mice failed to support a tumor-suppressor function for DCC in the mouse, but were consistent with the hypothesis that DCC is a component of the receptor for netrin-1, a neuronal chemoattractant. (from OMIM)
C17359	TP53_Gene	Ligand_Binding_Protein_Gene	TP53 Gene|P53|TP53|TRP53|Tumor Protein P53 (Li-Fraumeni Syndrome) Gene|Tumor Protein p53 Gene|p53|p53 gene	A tumor suppressor gene that normally inhibits the growth of tumors. This gene is altered in many types of cancer.
C17360	RB1_Gene	Regulatory_Gene	RB1 Gene|RB|RB1|Retinoblastoma 1 (Including Osteosarcoma) Gene	Cloned gene for Hereditary Retinoblastoma. The results of many experiments indicate that the normal function of the RB gene product is a negative regulator of cellular proliferation which is achieved by sequestering a variety of nuclear proteins involved in cellular growth. Other experiments indicate that the RB protein acts as a transcriptional repressor by targeting the E2F transcription factors, whose functions are required for entry into S phase.(from OMIM)
C17361	REX_Gene	Viral_Gene	REX Gene	The genes coding for the Regulator X (rex) protein of HTLV-I and II.  The Rex phosphoprotein binds to a cis-acting Rex response element in the RNA transcript.  It is required for the nuclear export of unspliced viral RNA, and therefore essential for packaging of the RNA in virions.
C17362	Tumor_Suppressor_Gene	Cancer_Gene	Tumor Suppressor Gene|Anti-Oncogene|Antioncogene|Tumor Suppressor|Tumor Suppressors|tumor suppressor gene	(TOO-mer) Genes in the body that can suppress or block the development of cancer.
C17363	TAX_Gene	Viral_Gene	TAX Gene	The genes coding for the Trans-Activator X (tax) protein of HTLV-I and II.  Tax activates transcription via interactions with the ATF/CREB transactivator(s) and the CBP/p300 coactivators which assemble as a multiprotein complex on the 21-bp repeat elements in the proviral LTR.  Tax also modulates expression of cellular genes via the ATF/CREB and NF-kappaB pathways.
C17364	Wilms_Tumor_Gene	Retired_Concepts	Wilms' Tumor Gene
C17365	HTLV-I_REX_Gene	REX_Gene	HTLV-I REX Gene	Rex gene of the HTLV-I virus.
C17366	HTLV-I_TAX_Gene	TAX_Gene	HTLV-I TAX Gene	Tax gene of the HTLV-I virus.
C17367	HTLV-II_REX_Gene	REX_Gene	HTLV-II REX Gene	Rex gene of the HTLV-II virus.
C17368	HTLV-II_TAX_Gene	TAX_Gene	HTLV-II TAX Gene	Tax gene of the HTLV-II virus.
C17369	Imaging_Technique	Techniques	Imaging Technique|Imaging Procedures|imaging procedures	Any method that involves obtaining an image, as opposed to a biochemical test or direct observation (e.g., biopsy, endoscopy).
C17370	Fluorescent_Antibody_Technique	Immunologic_Techniques	Fluorescent Antibody Technique|Immunofluorescence|Immunologic, Immunofluorescence	An immunological technique in which the antibodies are coupled with molecules which fluoresce under ultra violet (UV) light. This makes them particularly suitable for detection of specific antigens in tissues or on cells. (NCI2005)
C17371	L-Myc_Protein	MYC_Family_Protein	L-Myc Protein|L-Myc-1 Proto-Oncogene Protein|LMYC|Lung-Carcinoma MYC|MYCL Protein|MYCL1	L-MYC Protein belongs to the bZIP family of transcription factors and demonstrates multiple discrete regions of extensive homology to MYC and N-MYC.  L-MYC binds DNA as a heterodimer with MAX; efficient DNA binding requires dimerization with another bHLH protein.  The gene sequence is amplified 10- to 20-fold in the DNA of small-cell lung cancer (SCCL).  Several L-MYC mRNAs are produced in SCCL cells from a single gene by alternative splicing and use of alternative polyadenylation signals.  (from OMIM 164850, Swiss-Prot P12524, and NCI)
C17372	Integrin_Alpha-L	Cell_Adhesion_Molecule	Integrin Alpha-L|Alpha L Integrin Chain|CD11A|ICAM Ligand|ITGAL|Lymphocyte Function-Associated Antigen-1|Lymphocyte Function-Associated Antigen-1, Alpha Subunit	Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAL encodes the integrin alpha L chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. (from LocusLink)
C17373	Integrin_Alpha-M	Cell_Adhesion_Molecule	Integrin Alpha-M|CD11b|Complement Receptor Type 3, Alpha Subunit|ITGAM|MAC1 Alpha|MO1 Alpha	An adhesion-promoting leukocyte surface integrin heterodimer contains an alpha subunit of CD11b antigen and a beta subunit of CD18 antigen.  The heterodimer functions as a receptor for complement 3, and in cell-cell and cell-substrate adhesive interactions.  Major surface antigens on leukocytes include CR3A, LFA-1, and p150,95, which share a common beta chain linked to one of three alpha distinctive chains.  They promote adhesion of granulocytes to each other and to endothelial cells.  The CR3A alpha subunit (CD11b) is homologous to the alpha subunit of IIb/IIIa, a platelet glycoprotein that also serves adhesive functions.  CD11b also exhibits significant homology with portions of the alpha subunits of fibronectin, vitronectin, platelet IIb/IIIa receptors, and p150,95.  The protein consists of an N-terminal extracytoplasmic domain, a transmembrane segment, and a short C-terminal cytoplasmic domain.  (from OMIM and NCI)
C17374	Scanning_Tunneling_Microscopy	Atomic_Resolution_Microscopy	Scanning Tunneling Microscopy|Microscopy, Electron Scanning Tunnel|STM	A microscope that makes use of the phenomenon of electron tunneling to map the positions of individual atoms in a surface or to move atoms around on a surface. (Merriam-Webster Online Dictionary)
C17375	Murine_AIDS	Animal_Model	Murine AIDS|M-AIDS	mouse model of AIDS.
C17376	Mutagenesis	Molecular_Biology_Techniques	Mutagenesis|Genetics-Mutagenesis|Molecular Biology, Mutagenesis	Production of genetic alterations by any technique, including chemicals, radiation, recombination, or other molecular biology methods.
C17377	Insertional_Mutagenesis	Mutagenesis	Insertional Mutagenesis	Mutagenesis of DNA by the insertion of one or more bases.
C17378	Site-Directed_Mutagenesis	Mutagenesis	Site-Directed Mutagenesis|Targeted DNA Modification|Targeted Modification	Any of several methods used to create alterations in a gene at a specific location.
C17379	N-Myc_Protein	MYC_Family_Protein	N-Myc Protein|MYCN Protein|NMYC|NMYC Gene Product|Neuroblastoma MYC	The MYCN oncogene is amplified in approximately 25% of neuroblastoma tumors and is the most significant negative prognostic factor. In neuroblastoma, the MYCN oncogene directly activates genes required for DNA replication, and this may contribute to neoplastic transformation of these MYCN-amplified tumors. Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma. (from PMID 11861392 and NCI)
C17380	NF-kB	Protein_or_Riboprotein_Complex	NF-kB|NFKB|Nuclear Transcription Factor NF-kB	NF-kB is a heterodimer complex of two DNA-binding subunits from two families of ubiquitous, inducible, nuclear transcription activators involved in cytokine-induced activation of gene expression.  NFKB1 or NFKB2 is bound to REL, RELA, or RELB to form the NF-kB complex. NF-kB is inhibited by IkB proteins (NFKBIA or NFKBIB), which inactivate NF-kB by trapping it in the cytoplasm.  Phosphorylation of IkB by kinases (IKBKA or IKBKB) marks them for ubiquitination, allowing NF-kB translocation to the nucleus and DNA binding at kappa-B transcription enhancer motifs.  In B-lymphocytes, NF-kB binds to the immunoglobulin kappa light chain enhancer and in T-lymphocytes it binds to enhancers in virally infected cells, including HIV.  (from OMIM 164011, 164012, 164910, 164014, 604758, and NCI)
C17381	Occupational_Health	Public_Health	Occupational Health
C17382	p21_H-Ras_Protein	p21_RAS_Protein	p21 H-Ras Protein|H-Ras Protein|HRAS|Ha-ras Protein|p21 ha-ras	p21 H-RAS protein is encoded by the H-RAS gene.  RAS proteins are involved in transmembrane signal transduction as monomeric GTP-binding proteins, with intrinsic GTPase activity, that alternate between an inactive GDP-bound form and an active GTP-bound form.  RAS proteins are activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein.  Mitogen-stimulated RAS enhances MYC accumulation by stabilizing MYC protein.  This stabilization is dependent on the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC.  Mutations of specific amino acids activate c-RAS to transform cells and are implicated in a variety of human tumors.  Allelic deletions of HRAS are correlated with progression and metastasis of carcinomas and sarcomas.  (from OMIM 190020, SWISS-PROT P01112, and NCI)
C17383	p21_K-Ras_Protein	p21_RAS_Protein	p21 K-Ras Protein|K-Ras 2A|K-Ras p21 Protein|K-Ras-2 Protein|K-Ras-2 p21|KRAS2|Ki-Ras|c-K-Ras|c-K-Ras Protein	p21 K-RAS protein is encoded by the K-RAS gene.  Two KRAS isoforms are produced by alternative splicing.  RAS proteins are involved in transmembrane signal transduction as monomeric GTP-binding proteins, with intrinsic GTPase activity, that alternate between an inactive GDP-bound form and an active GTP-bound form.  RAS proteins are activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein.  Mitogen-stimulated RAS enhances MYC accumulation by stabilizing MYC protein.  This stabilization is dependent on the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC.  Mutations of specific amino acids activate c-RAS to transform cells and are implicated in a variety of human tumors.  KRAS is involved in malignancy much more often than is HRAS.  (from OMIM 190070, SWISS-PROT P01116, P01118, and NCI)
C17384	p21_N-Ras_Protein	p21_RAS_Protein	p21 N-Ras Protein|N-Ras Protein|NRAS|Transforming Protein p21 N-Ras	p21 N-RAS protein is encoded by the N-RAS gene.  RAS proteins are involved in transmembrane signal transduction as monomeric GTP-binding proteins, with intrinsic GTPase activity, that alternate between an inactive GDP-bound form and an active GTP-bound form.  RAS proteins are activated by a guanine nucleotide-exchange factor and inactivated by a GTPase-activating protein.  Mitogen-stimulated RAS enhances MYC accumulation by stabilizing MYC protein.  This stabilization is dependent on the RAS/RAF/MAPK pathway, which appears to inhibit the proteasome-dependent degradation of MYC.  Mutations of specific amino acids activate c-RAS to transform cells and are implicated in a variety of human tumors.  (from OMIM 164790, SWISS-PROT P01111, and NCI)
C17385	Privacy	Conceptual_Entities	Privacy	Privacy; the quality of being secluded from the presence or view of others; the condition of being concealed or hidden; the ability of a person to control the availability of information about and exposure of him- or herself. (from Wordnet and Wikipedia)
C17386	Cyclin-Dependent_Kinase-1	Cyclin-Dependent_Kinase	Cyclin-Dependent Kinase 1|CDC2|CDK1|Cell Cycle Controller cdc2|Cell Division Control Protein 2 Homolog|Cell Division Cycle 2|Cell Division Cycle 2 Protein|p34 Protein Kinase|p34(CDC2)|p34CDC2	A serine/threonine protein kinase subunit of the M-phase promoting factor complex, required for entry into S-phase and mitosis. A member of the CDC2/CDKX subfamily, p34(cdc2) forms a complex with a Cyclin, and phosphorylates RNA Polymerase II.  CDC2 gene expression is transcriptionally regulated and phosphorylation regulates cdc2 activity. (from SWISS-PROT P06493, OMIM 116940, and NCI)
C17387	Tumor_Protein-p53	Cell_Cycle_Protein	Tumor Protein p53|Cellular Tumor Antigen P53|P53|P53 Protein|Phosphoprotein P53|TP53|Tumor Suppressor p53|p53 Tumor Suppressor	A homo-tetrameric, DNA-binding, trans-activator of genes involved in cell division. p53 induces growth arrest or apoptosis and is mutated or inactivated in about 60% of cancers. JNK-p53 and mdm2-p53 complexes regulate ubiquitination and degradation of p53. (from SWISS-PROT P04637, OMIM 191170, and NCI)
C17388	p21_RAS_Protein	RAS_Superfamily_Protein	p21 RAS Protein|p21 RAS Family Protein	Cellular protein encoded by the RAS genes. The protein has intrinsic GTPase activity and is involved in transmembrane signal transduction as a guanine nucleotide binding protein. Elevated levels of p21 c-ras have been associated with neoplasia.
C17389	p60-SRC	SRC_Family_Tyrosine_Kinase	p60-SRC|SRC|p60src	The protein product of the SRC Gene; a cytoplasmic protein with tyrosine specific protein kinase activity, that associates with the cytoplasmic face of the plasma membrane. (from Online Medical Dictionary)
C17390	ABL1_Tyrosine_Kinase	Protein_Tyrosine_Kinase	ABL1 Tyrosine Kinase|ABL Tyrosine Kinase|ABL1|P150|Proto-Oncogene Tyrosine -Protein Kinase ABL|c-ABL Protein	ABL1 tyrosine kinase has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes present in many cases of chronic myelogenous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1 tyrosine kinase. (from LocusLink)
C17391	c-MYC_Protein	MYC_Family_Protein	c-MYC Protein|MYC|MYC Transcription Factor	Product of the c-myc proto-oncogene.  A nuclear protein which is involved in nucleic acid metabolism and in mediating the cellular response to growth factors.
C17392	Colony_Stimulating_Factor-1_Receptor	Colony_Stimulating_Factor_Receptor	Colony Stimulating Factor 1 Receptor|C-FMS|CD115|CSF-1-R|CSF1R|CSF1R Gene Product|Macrophage Colony Stimulating Factor I Receptor|c-FMS Protein	Colony stimulating factor-1 receptor protein (972 aa, ~108 kDa) is encoded by the c-fms proto-oncogene (CSF1R Gene). The protein is a transmember receptor for colony-stimulating factor and has tyrosine kinase activity.
C17393	Colony_Stimulating_Factor_Receptor	Cytokine_Receptor	Colony Stimulating Factor Receptor|CSF Receptor|CSFR|Colony Stimulating Factor Receptor Family
C17394	RB_Protein	Regulatory_Protein	RB Protein|P105-RB|PP110|RB1|Retinoblastoma Associated Protein|Retinoblastoma Protein	RB protein regulates cell proliferation by inhibiting cell cycle progression in G1.  This function involves a complex interaction with other proteins, such as E2F, MYC, TGFB, p16(INK4A), CDK4/CDK6, transcription factor DRTF1, and MDM2.
C17395	S-Phase	Cell_Cycle_Stage	S Phase|Synthesis Period|Synthesis Phase	Phase of the cell cycle following G1 and preceding G2 when the entire DNA content of the nucleus is replicated (Synthesis phase). It is achieved by bidirectional replication at multiple sites along each chromosome.
C17396	Sequence_Tagged_Site	Genetic_Marker	Sequence Tagged Site|STS	Short (200 to 500 base pairs) DNA sequence that is operationally unique and has a single occurrence in the human genome and whose location and base sequence are known and therefore they can be used as landmarks in genome mapping.
C17397	Oncogene_ABL1	ABL1_Gene	Oncogene ABL1|ABL|Abelson Murine Leukemia Viral Oncogene Homolog|Oncogene, ABL|Oncogene, ABL1	Human v-abl Abelson murine leukemia viral oncogene homolog 1 (ABL1) gene, located at 9q34.1, encodes proto-oncogene tyrosine-protein kinase ABL1 protein. Alternative splicing of this gene produces two protein isoforms. A t(9;22) translocation, resulting in the fusion of the BCR and ABL1 genes, has been detected in many cases of chronic myelogeneous leukemia.. This BCR-ABL fusion gene is also present in acute myeloid leukemia and acute lymphoblastic leukemia.
C17398	Oncogene_SRC	SRC_Gene	Oncogene SRC	Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20.
C17399	Women_s_Health	Public_Health	Women's Health	Many diseases and disorders affect men and women differently.  Some predominantly effect one or the other while others take different clinical courses, with differing prognoses and outcomes.  Women's health takes a specific focus on the health and wellbeing of women.
C17400	Speech_Pathology	Allied_Health_Sciences	Speech Pathology
C17401	B-MYB_Protein	Transcription_Factor	B-MYB Protein|BMYB|BMYB Gene Product|MYB-Related Protein B|MYBL2	A MYB family transcription factor, B-MYB Protein is essential during cell cycle progression; MYBL2 activates CDC2 and cyclin D1 gene expression in proliferating fibroblasts.  MYBL2 expression is regulated at the G1/S transition, and its transcription relies on E2F activity in a cell cycle-dependent manner.  MYBL2 transcripts are detectable in a variety of dividing cell types.  (from OMIM 601415 and NCI)
C17402	CD31_Antigen	Cell_Adhesion_Molecule	CD31 Antigen|EndoCAM|GPIIA'|PECAM-1|PECAM1|Platelet Endothelial Cell Adhesion Molecule	A cell adhesion molecule present on virtually all monocytes, platelets, and granulocytes, CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.  An integral membrane glycoprotein that contains six extracellular Ig-like domains, one transmembrane domain, and a cytoplasmic domain, CD31 is most similar to the CAM subgroup of the Ig superfamily.  PECAM1 is implicated in several functions, including transendothelial migration of leukocytes, angiogenesis, and integrin activation.  Ig superfamily members mediate cell adhesion, or antigen recognition, T-cell receptors, and MHC molecules.  A subgroup contains one or more cytoplasmic ITIM motifs.  PECAM1 has six ITIMs and may serve as a negative regulator of platelet-collagen interactions that may limit growth of platelet thrombi on collagen surfaces.  (from OMIM 173445 and NCI)
C17403	Lymphocyte_Function-Associated_Antigen-3	Cell_Adhesion_Molecule|Cell_Surface_Receptor	Lymphocyte Function-Associated Antigen-3|CD2 Ligand|CD58|CD58 Antigen|LFA-3|MSK2	Lymphocyte Function-Associated Antigen-3 (LFA-3), encoded by the CD58 gene, is a member of the Ig gene superfamily and a ligand for CD2 via heterophilic adhesion between the N-terminal domains. LFA-3 glycoproteins have a wide distribution on hematopoietic and non-hematopoietic cells and are strongly expressed on macrophages. Interaction between CD2 and its counter-receptor, LFA-3, on opposing cells optimizes immune recognition, facilitating contacts between helper T-lymphocytes and antigen-presenting cells as well as between cytolytic effectors and target cells. (from OMIM 153420 and NCI)
C17404	CD72_Antigen	Cell_Adhesion_Molecule	CD72 Antigen|CD100 Receptor|CD72|LYB2|Mouse Homolog LYB2	Expression of CD72 is restricted to B-lineage cells and is turned off in differentiated antibody-secreting plasma cells.  CD72 may participate in signals for B-cell proliferation and differentiation.  In the immune system, CD72 appears to be a receptor for leukocyte activation antigen, CD100.  CD72 may also be the ligand for CD5, a receptor that regulates T-cell proliferation.  (from OMIM 107272, SWISS-PROT P21854, and NCI)
C17405	Topoisomerase-IV	Bacterial_Protein	Topoisomerase IV|DNA Topoisomerase IV|Topo IV	Topoisomerase IV belongs to type II topoisomerase family (includes bacterial DNA gyrase, and eukaryotic topo II).  The type II enzymes are multisubunit proteins, and require ATP for overall catalytic activity. Topoisomerase IV (is a potent decatenase) is required to untangle daughter chromosomes following replication.
C17406	Endoglin	Growth_Factor_Receptor	Endoglin|CD105|CD105 Antigen|END|ENG|Endoglin (Osler-Rendu-Weber Syndrome 1)|HHT1|ORW|ORW1|Transforming Growth Factor P Receptor III	Endoglin is a Transforming Growth Factor Receptor present on tumor vasculature.  It is a marker of angiogenesis and a target for cancer therapy.
C17407	Ecotropic_Virus_Integration-1_Site_Protein	Transcription_Factor	Ecotropic Virus Integration 1 Site Protein|EVI 1 Protein|EVI1	The nuclear Ecotropic Virus Integration Site 1 Protein may interact with CTBP1 and is involved in chronic myelogenous leukemia by a chromosomal translocation t(3;21)(q26;q22) that involves EVI1 and AML1.  (from Swiss-Prot Q03112 and NCI)
C17408	MAP-Kinase-3	Mitogen-Activated_Protein_Kinase	MAP Kinase 3|Extracellular Signal-Regulated Kinase 1|MAPK3|Mitogen-Activated Protein Kinase 3|p44 (MAPK)|p44ERK1|p44MAPK	Mitogen-activated protein kinases (MAPKs) are serine-threonine protein kinases activated in response to a variety of extracellular stimuli and encoded by a multigene family. The MAPKs are part of complex protein kinase cascades. One class of MAPKs includes (among other ERKs) the extracellular signal-regulated kinases ERK1 (p44MAPK) and ERK2 (p42MAPK), activated by the RAF/MEK/ERK signaling pathway. ERK1/2 are widely involved in eukaryotic signal transduction. Upon activation, ERKs translocate to the nucleus and phosphorylate nuclear targets. Phosphorylated ERKs form essential dimers with phosphorylated and unphosphorylated ERK partners. Dimerization is part of the mechanism of MAP kinase family action. Mitogen-activated protein kinases (MAPKs) promote entry in the cell cycle.  (from OMIM 601795, Swiss-Prot P27361, and NCI)
C17409	FK506_Binding_Protein	Ligand_Binding_Protein	FK506 Binding Protein|FKBP|KBP	A class of immunosuppressant binding proteins (immunophilins) specific for FK506 (tacrolimus) and rapamycin.
C17410	GLI3_Protein	GLI_Family_Protein	GLI3 Protein|GLI-Kruppel Family Member 3 Protein|GLI3|Glioma-Associated Oncogene Homolog 3 Protein|Zinc Finger Protein GLI3	GLI3 Protein is a putative zinc finger DNA-binding transcription factor of the GLI-Kruppel family.  GLI3 is homologous to Drosophila Cubitus interruptus (Ci), which regulates patched, gooseberry, and decapentaplegic genes.  In response to hedgehog signaling, the full-length cytoplasmic transcriptional activator form of Ci can be cleaved to a nuclear transcription repressor form.  Based on GLI3 mutations and phenotypes, GLI3 shows transcriptional activation or repression, and subcellular localization, similar to Ci.  Cytoplasmic GLI3 activates PTCH gene expression.  PKA-dependent processing of vertebrate GLI3 in the developing limb generates the repressor form, which appears to be antagonized by sonic hedgehog signaling.  Mutations of GLI3 may be responsible for Greig Cephalopolysyndactyly Syndrome, Pallister-Hall Syndrome, and Postaxial Polydactyly, suggesting specific roles during development.  (from OMIM 165240 and NCI)
C17411	Fibroblast_Growth_Factor_Receptor-2	Fibroblast_Growth_Factor_Receptor_Family	Fibroblast Growth Factor Receptor 2|FGFR-2|FGFR2|KGF Receptor|KGFR|Keratinocyte Growth Factor Receptor	KGF is a potent mitogenic paracrine mediator of epithelial cell proliferation. The keratinocyte growth factor receptor is a FGFR RTK family member with three extracellular Ig-like domains, a single membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. Two alternatively spliced FGFR2 gene products, KGFR and BEK, vary in sequence within the third extracellular Ig loop, which influence ligand-binding characteristics. Control of these alternative splice sites is thought to involve transacting factors. These receptors also have different patterns of expression. KGFR appears to have a role in skin development; BEK is preferentially expressed in osteogenesis. Dimerization of the FGFR2 ectodomain is induced by binding to FGF1 and a heparin decasaccharide, essential in FGF signaling. (from OMIM 176943 and NCI)
C17412	Neurofibromin	Signaling_Protein	Neurofibromin|NF1	The 250 kD neurofibromin product, encoded by the tumor suppressor NF1 gene, is thought to restrict cell proliferation by functioning as a RAS-specific GTPase-activating protein.  NF1 contains a GAP-related domain that down regulates p21(RAS) by stimulating its GTPase activity.  NF1 protein is found in all tissues in a large complex and may be associated with the intermediate filament cytoskeleton.  NF1 gene expression is most abundant in the adult nervous system; neurofibromin may act as a negative regulator of neurotrophin-mediated signaling.  NF1 mutations are associated with neurofibromatosis type I.  (from OMIM 162200 and NCI)
C17413	Sperm_Adhesion_Molecule-1	Cell_Adhesion_Molecule	Sperm Adhesion Molecule 1|Hyaluronidase PH-20|SPAM1|Sperm Surface Protein PH-20	Hyaluronidase degrades hyaluronic acid, a major structural proteoglycan found in extracellular matrices and basement membranes. Six members of the hyaluronidase family are clustered into two tightly linked groups on chromosome 3p21.3 and 7q31.3. This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. (from LocusLink)
C17414	CRK_Protein	Transcription_Factor	CRK Protein|Adapter Molecule CRK|CRK|P38|Proto-Oncogene c-CRK	Containing SH2 and SH3 homology domains that interact with ABL, the tumor suppressor CRK protein appears to be a protein involved in signal transduction.  (from OMIM 164762 and NCI)
C17415	RHOA_Protein	RAS_Superfamily_Protein	Ras Homolog Gene Family, Member A|ARH12|ARHA|Aplysia Ras-Related Homolog 12|H12|RHO12|RHOA|RHOA Protein|RHOH12|Transforming Protein RHOA	RHO A GTP-binding protein is involved in regulating signal transduction pathways that control assembly of focal adhesions and actin stress fibers.  Rho regulates remodeling of the actin cytoskeleton during cell morphogenesis and motility.  Active Rho signals to its downstream effector ROCK1, which phosphorylates and activates LIM kinase.  LIM kinase, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.  (from OMIM 165390 and NCI)
C17416	RHOC_Protein	RAS_Superfamily_Protein	RHOC Protein|ARH9|ARHC|Aplysia RAS-Related Homolog 9|H9|RAS Homolog Gene Family, Member C|RHOH9|Transforming Protein RHOC	RHO C protein is a product of the ARHC gene that regulates remodeling of the actin cytoskeleton during cell morphogenesis and motility.  Rho C enhances metastasis when over expressed, whereas a dominant-negative Rho inhibits metastasis.  Analysis of the phenotype of cells expressing dominant-negative Rho C indicates that Rho C is important in tumor cell invasion.  (from OMIM 165380 and NCI)
C17417	RNA_Helicase	Helicase	RNA Helicase
C17418	SCL_Transcription_Factor	Transcription_Factor	SCL Transcription Factor|SCL|Stem Cell Leukemia Hematopoietic Transcription Factor|Stem Cell Protein|T-Cell Acute Lymphocytic Leukemia 1 Protein|TAL1|TAL1 Gene Product	A probable positive hematopoietic transcriptional regulator, TAL1 belongs to the bHLH family and binds DNA as a hetero-dimer with E12 and E47, which recognize the enhancer E-box DNA motif (5'-CANNTG-3'). TAL1 also binds Rhombotin-2 and DRG1. Some T-ALL leukemias involve TAL1 and TCRA gene translocations, t(1;14)(p32;q11). (from SWISS-PROT P17542, OMIM 187040, and NCI)
C17419	SPT6_Protein	Protein_Complex_Subunit	SPT6 Protein|Chromatin Structural Protein|Chromatin Structure Regulator Homolog|EMB-5|SUPT6H|SUPT6H Gene Product|Suppressor of TY 6 Homolog	A nuclear protein that may regulate transcription through control of chromatin structure. SPT6 contains a highly acidic region, a degenerate SH2 domain, and a leucine zipper. (from OMIM 601333 and NCI)
C17420	PEA3	Mouse_Protein	PEA3|PEA3 Transcription Factor|Polyomavirus Enhancer A Binding Protein 3|Polyomavirus Enhancer Activator 3	PEA3 is a member of the ETS-related transcription factor family and contains a DNA-binding ETS domain and an N-terminal acidic domain. PEA3 appears to bind to the core consensus sequence GGAA recognized by other ETS proteins. PEA3 is widely expressed (though not in normal lymphocytes) and is especially high in brain and placenta.  (from OMIM 601600 and NCI)
C17421	CHO_Cells	Hamster_Cell_Line	CHO Cells|CHO|Chinese Hamster Ovary Cell	The parental CHO cell line initiated from a biopsy of an ovary of an adult Chinese hamster.
C17422	NIH_3T3	Mouse_Cell_Line	NIH/3T3|NIH 3T3 Cells	a ubiquitous tissue culture model for nontransformed animal cells; derived from nonneoplastic immortalized fibroblasts.
C17423	Drug_Delivery_System	Medical_Device	Drug Delivery System|Drug Delivery|Drug Delivery Systems
C17424	NF1_Gene	Signaling_Pathway_Gene	NF1 Gene|NF1|Neurofibromin 1 (Neurofibromatosis, Von Recklinghausen Disease, Watson Disease) Gene|VRNF|WSS	NF1 encodes the protein neurofibromin, which appears to be a negative regulator of the ras signal transduction pathway. In addition to type 1 neurofibromatosis, mutations in NF1 can also lead to juvenile myelomonocytic leukemia. (from LocusLink)
C17425	NF2_Gene	Signaling_Pathway_Gene	NF2 Gene|ACN|BANF|NF2|Neurofibromin 2 (Bilateral Acoustic Neuroma) Gene|SCH	Expressed in kidney, lung, breast, ovary, and fetal brain, human NF2 Gene (ERM family) at 22q12.2 encodes two isoforms of Merlin, similar to ERM proteins that may link cytoskeleton and cell membrane.  LIF and NFH map to the NF2 region.  Merlin may maintain cytoskeletal organization or act as a membrane stabilizing protein.  It contains a band 4.1-like domain and binds to EBP-50, an ERM-interacting phosphoprotein.  Merlin interacts with HRS, an HGF-regulated tyrosine kinase substrate.  The conserved FERM domain and C-terminus may contain key functional domains.  NF2 defects result in neurofibromatosis 2.  Mutant proteins alter cell adhesion, a possible step in NF2 pathogenesis.  (from SWISS-PROT, OMIM, and NCI)
C17426	Pulsed-Field_Gel_Electrophoresis	Gel_Electrophoresis	Pulsed-Field Gel Electrophoresis|Electrophoresis, Gel, Pulsed-Field|Fractionation, Pulse Field	Pulsed-field gel electrophoresis (PFGE) is a method used to separate high molecular weight linear DNA fragments that are greater than 50 kilobases (kb) in size. Fragments are separated by pulsing an electrical field across an agarose gel rather than applying the constant field used in conventional electrophoresis. (NCI2005)
C17427	Smoking_Cessation	Behavior	Smoking Cessation	Discontinuation of the habit of smoking.
C17428	Glucose_Phosphate_Isomerase	Isomerase	Glucose Phosphate Isomerase|AMF|Autocrine Motility Factor|D-Glucose-6-Phosphate Ketol-Isomerase|EC 5.3.1.9|GPI|Glucosephosphate Isomerase|Hexose Monophosphate Isomerase|Hexosephosphate Isomerase|Neuroleukin|Oxoisomerase|Phosphoglucose Isomerase|Phosphohexomutase|Phosphohexose Isomerase|Phosphosaccharomutase|SA-36|Sperm Antigen-36	Encoded by human GPI Gene (GPI Family), Glucose-6-Phosphate Isomerase, Neuroleukin, and Autocrine Motility Factor function in different capacities. In glycolysis and gluconeogenesis, homodimeric cytoplasmic GPI catalyzes reversible G6P and F6P isomerization. Produced by lectin-stimulated T-cells, secreted non-mitogenic NLK lymphokine acts early in antibody-secreting cell formation to induce Ig secretion. Also a neurotrophic factor for spinal and sensory neurons, NLK exhibits GPI activity. AMF is a 558-amino acid 55-kD autocrine motility polypeptide. The gene product is partly homologous to a conserved region of HTLV-III-LAV external envelope protein. Gene defects cause nonspherocytic hemolytic anemia and hydrops fetalis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C17429	Neural_Network	Artificial_Intelligence	Neural Network|Neural Networks (Computer)	A neural network is a computer algorithm to solve non-linear optimisation problems. The algorithm was derived in analogy to the way the densely interconnected, parallel structure of the brain processes information.
C17430	Vinculin	Actin-Binding_Protein	Vinculin|VCL	Encoded by a single human tumor suppressor VCL Gene, Vinculin contains 1,066 amino acids with strong similarity to other vinculins and alpha-catenins. Alternative splice product metavinculin contains additional 68-79 variable and highly conserved amino acids near the C-terminus. Involved in cell adhesion, vinculin is associated with the cytoplasmic face of adherens-type junctions and involved in anchoring F-actin to the plasma membrane. Vinculin is phosphorylated on serines, threonines and tyrosines and is acylated by myristic acid and/or palmitic acid. Vinculin exhibits self-association properties and appears to be the major talin-binding protein in platelets; 150 kD metavinculin also interacts strongly with talin.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C17431	HIV-p24_Antigen	GAG_Protein	HIV p24 Antigen	HIV-p24 antigen, an important core protein of the human immunodeficiency virus, is encoded by the gag gene. This protein can be detected in serum either in its free form or bound by anti-p24 antibody. Individuals who are HIV-seropositive elicit a significant immune response to p24. Thus, detection of p24 antibodies by ELISA or Western analysis is a screening method utilized to determine the presence of HIV.
C17432	T-Cell_Receptor_Gamma-Delta	T-Cell_Receptor	T-Cell Receptor, Gamma-Delta|TCR Gamma-Delta
C17433	T-Cell_Receptor_Alpha-Beta	T-Cell_Receptor	T-Cell Receptor, Alpha-Beta|TCR Alpha-Beta
C17434	Glycosyltransferase	Transferase	Glycosyltransferase|EC 2.4	An enzyme that catalyzes the transfer of glycosyl groups to an acceptor. The acceptor molecules are frequently carbohydrate molecules, or inorganic phosphates. A special subsect of glycosyltransferases can also catalyze hydrolysis. Subclasses include Hexosyltransferases, Pentosyltransferases and Sialyltransferases. 2005
C17435	PC-12	Rat_Cell_Line	PC-12|PC12 Cells|Pheochromocytoma 12 Cell Line	PC-12 adheres poorly to plastic, and tends to grow in small clusters. Attachment is improved by using collagen coated flasks.
C17436	Immunoscintigraphy	Radionuclide_Scanning	Immunoscintigraphy|Radioimmunodetection|immunoscintigraphy	An imaging procedure in which antibodies labeled with radioactive substances are given to the person. A picture is taken of sites in the body where the antibody localizes.
C17437	JUN_Protein	JUN_Family_Protein	JUN Protein|JUN|JUN Protein Transcription Factor|c-JUN Protein|v-jun Avian Sarcoma Virus 17 Oncogene Homolog	JUN protein is encoded by the serum-induced human c-JUN Gene (JUN Family) at 1p32-p31, dimeric DNA-binding JUN Protein (331-aa, 35.7-kDa) is involved in growth-related transcriptional control. JUN appears to comprise three distinct functions: leucine zipper dimerization (with c-FOS) to form enhancer-binding protein AP1, TGA(C/G)TCA DNA-binding on the carboxyl end, and transcriptional activation (enhanced by phosphorylation). JUN may also interact with SMAD3/SMAD4 heterodimers. Oncogenic transformation can involve constitutive expression of c- JUN.
C17438	FOS_Protein	FOS_Family_Protein	FOS Protein|FBJ Murine Osteosarcoma Viral Oncogene Homolog|FOS|c-fos Protein	FOS is involved in growth-related transcriptional control, is a key regulator of osteoclast-macrophage lineage determination, and is a major component of the heterodimeric DNA-binding AP-1 transcription factor complex, which includes JUN family members.  Both proteins contain a bZIP region. AP-1 binds to TREs (TPA-responsive elements) in the promoters of target genes.  (from OMIM 164810 and NCI)
C17439	FOS_Oncoprotein	Oncoprotein	FOS Oncoprotein|Cellular Oncogene c-FOS|G0S7 Protein	c-FOS protein is a transcription factor critical in regulating the development of the skeleton.  c-FOS protein is a major component of the DNA-binding AP-1 transcription complex, which also includes members of the JUN family.  Each protein contains a bZIP domain and a leucine zipper domain.  FOS oncoproteins derive from mutated FOS genes.  These proteins have been found in the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses, which induce osteogenic sarcomas in mice.  The FBJ-MSV v-fos gene encodes a 55 kD protein and the FBR-MSV v-fos gene encodes a 75 kD fusion protein.  (from OMIM 164810 and NCI)
C17440	Oncogene_FOS	FOS_Gene	Oncogene FOS|FBJ Murine Osteosarcoma Oncogene|FOS	Retrovirus-associated DNA sequences (fos) originally isolated from the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses. The proto-oncogene c-fos encodes a nuclear protein that dimerizes with Jun via a zipper motif to form the transcription factor AP1 and is involved in growth-related transcriptional control. The insertion of c-fos into FBJ-MSV or FBR-MSV induces osteogenic sarcomas in mice. The human c-fos gene is located at 14q21-3 on the long arm of chromosome 14.
C17441	CD8_Antigen_Beta_Polypeptide-1	Cell_Adhesion_Molecule	CD8 Antigen, Beta Polypeptide 1|CD8|CD8B|CD8B1|LYT3|T-Cell Glycoprotein CD8b	suppressor T-lymphocyte marker that functions as a receptor for MHC class I antigen.
C17442	Anisotropy	Physical_Phenomena_or_Properties	Anisotropy	Anisotropy is the property of being anisotropic; having a different value when measured in different directions.
C17443	Adverse_Drug_Experience_Reporting_System	Computer_System	Adverse Drug Experience Reporting System|AdEERS|Adverse Event Expedited Reporting System	The Adverse Event Expedited Reporting System (AdEERS) is a Web application developed for the electronic submission of Expedited Reports to the NCI for serious and/or unexpected Adverse Events, deaths, and other events defined in the NCI Guidelines: Adverse Event Reporting Requirements for NCI Investigational Agents
C17444	Protein_Tyrosine_Phosphatase	Phosphoprotein_Phosphatase	Protein Tyrosine Phosphatase|Cytosolic Protein Tyrosine Phosphastase	Encoded by Protein Tyrosine Phosphatase Genes, Protein Tyrosine Phosphatases are a group of enzymes that specifically remove tyrosine-bound phosphate groups from many phosphoproteins, including many enzymes phosphorylated by a tyrosine kinase. Together with protein tyrosine kinases, Tyrosine Phosphatases regulate tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis. (NCI)
C17445	Caregiver	Person	Caregiver	Caregiver; the primary person in charge of care of a patient, usually a family member or a designated health care professional.
C17446	Catheter	Medical_Device	Catheter|catheter	(KATH-i-ter) A flexible tube used to deliver fluids into or withdraw fluids from the body.
C17448	Serine_Protease_Inhibitor_Kazal_Type-1	Serine_Proteinase_Inhibitor	Serine Protease Inhibitor, Kazal Type 1|PSTI|PSTI Protein|Pancreatic Secretory Trypsin Inhibitor|SPINK1|Tumor Asssociated Trypsin Inhibitor	SPINK1 is secreted from pancreatic acinar cells into pancreatic juice and is thought to prevent trypsin-catalyzed premature activation of pancreatic zymogens.  It is also found in serum and various normal tissues; SPINK1 is produced by gastrointestinal tract mucosa where it may protect mucosal cells from proteolytic breakdown.  (from OMIM 167790 and NCI)
C17449	Antibiotic_Resistance	Drug_Resistance	Antibiotic Resistance	The mechanisms, functions, activities, or processes exhibited by microorganisms, especially bacteria, to resist or to become tolerant to antibiotics.
C17450	AP-1	Protein_or_Riboprotein_Complex	AP-1|AP1|Activator Protein 1|Enhancer-Binding Protein AP1|Transcription Factor AP-1	A dimeric complex of related bZIP JUN, FOS, MAF and ATF transcription factors that must dimerize in order to bind to AP1 recognition sites (TPA-Responsive Element, TRE) or cAMP response elements in DNA, AP-1 controls basal and inducible transcription of several genes.
C17451	FOS_Family_Gene	Transcription_Factor_Gene	FOS Family Gene|FOS Gene	FOS Family Genes encode nuclear leucine zipper FOS Family Proteins (FOS, FOSB, FOSL1, and FOSL2) that can dimerize with JUN Family proteins and bind DNA as the AP-1 transcription factor complex to regulate transcription in cell proliferation, differentiation, and transformation. (NCI)
C17452	JUN_Family_Gene	Transcription_Factor_Gene	JUN Family Gene|JUN Genes|JUN Proto-oncogene Family	JUN Family Genes encode nuclear leucine zipper JUN Family Proteins (JUN, JUNB, and JUND) that can homodimerize, or heterodimerize with nuclear leucine zipper FOS Family Proteins, to form the specific promoter/enhancer DNA binding AP-1 transcription factor complex that regulates target gene transcription in cell proliferation, differentiation, and transformation. (NCI)
C17453	Conference	Event	Conference	Conference; a prearranged meeting for consultation or exchange of information or discussion, especially one with a formal agenda.
C17454	Diagnostic_Test	Test|Test_Generic	Diagnostic Test|Diagnostic Lab Test	Approved methods, procedures, or tests to diagnose the disease, disordered function, or disability.
C17455	Enzyme_Immunoassay	Immunoenzyme_Techniques	Enzyme Immunoassay|Immunologic, Enzyme Linked Immunoassay	Any of several immunoassay methods that use an enzyme covalently linked to an antigen or antibody as a label; the most common types are enzyme-linked immunosorbent assay (ELISA) and enzyme-multiplied immunoassay technique (EMIT).
C17456	Experimental_Model	Model_System	Experimental Model|Experimental Models, Other
C17457	Molecular_Genetics	Genetics	Molecular Genetics	The study of the flow and regulation of genetic information between DNA, RNA, and protein molecules. (On-line Medical Dictionary)
C17458	G_Protein	Signaling_Protein	G Protein|GTP-Binding Protein|Guanine Nucleotide Binding Protein	G Proteins are a family of small membrane-bound regulatory proteins that act as GTP/GDP-binding molecular switches controlling a wide range of biological processes including: transmembrane receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP.
C17459	Hispanic	Ethnic_Group	Hispanic|Hispanic Populations|Hispanic or Latino|Hispanics or Latinos|Latino Population|Spanish Origin	Populations of Spanish, Portuguese, or Latin American descent residing in countries other than the country of their origin. (PSY94)
C17460	Histone-H2B	Histone	Histone H2B	Histone H2B is a core subunit of the eukaryotic nucleosome complex. Histones are basic nuclear proteins responsible for the nucleosome structure of chromatin. Repeating nucleosome units contain two molecules each of Histones H2A, H2B, H3, and H4 that form an octamer complex around which approximately 146 base pairs of DNA is wrapped. Linker Histone H1 interacts with DNA between nucleosome units in mediating chromatin compaction into higher order structures. (NCI)
C17461	Initiation_Factor	Translation_Process_Protein	Initiation Factor|Translation Initiation Factor|Translational Initiation Factor	One of several soluble proteins involved in the initiation of protein or RNA synthesis. (On-line Medical Dictionary
C17462	JUNB_Protein	JUN_Family_Protein	JUNB Protein|G0S3|JUNB|JUNB Protein Transcription Factor|Transcription Factor JUN-B	A nuclear transcription factor of the bZIP family, JUNB regulates gene activity following primary growth factor response. JUNB binds the 5'-TGA(C/G)TCA-3' DNA sequence as an homo-dimer, or as a hetero-dimer with another member of the JUN/FOS family. JUNB appears to be a key transcriptional regulator of myelopoiesis and a potential tumor suppressor gene. (from SWISS-PROT P17275, OMIM 165161, and NCI)
C17463	JUND_Protein	JUN_Family_Protein	JUND Protein|JUND|JUND Protein Transcription Factor|Transcription Factor JUN-D	JUND belongs to the bZIP family and probably binds to AP-1 sites as a dimmer to stimulate activity of the associated promoter. Having an apparent anti-apoptotic role, JUND protects cells from senescence, or apoptotic responses to stress stimuli, by acting as a modulator of the RAS signaling pathways to p53. (from SWISS-PROT P17535, OMIM 165162, and NCI)
C17464	Oncogene_MYC	MYC_Gene	Oncogene MYC|Avian Myelocytomatosis Viral Oncogene Homolog|MYC	A viral and cellular gene. A proto-oncogene, identified in several avian tumors, encoding a nuclear protein with a leucine zipper motif.
C17465	Personal_Communication	Communication	Personal Communication|Interpersonal Communication	The exchange of information between people.  Often used as a citation when information is passed from one researcher to another, but is not published.
C17466	Rous_Sarcoma	Experimental_Organism_Diagnoses	Rous Sarcoma	A fibrosarcoma, originally observed in a Plymouth Rock hen, now thought to be an expression of infection by certain viruses of the avian leukosis-sarcoma complex in the family
C17467	Senescence	Aging-Related_Process	Senescence	The state of being old.
C17468	Socioeconomic_Factors	Demographics	Socioeconomic Factors|Socioeconomic Status	An overall rank based on characteristics such as education and occupation, used to describe people's positions in stratification systems.
C17469	Taxonomy	Biology	Taxonomy|Taxonomy, General	The theories and techniques of naming, describing, and classifying organisms, and the study of the relationships of taxa. (from On-line Medical Dictionary)
C17470	Telomerase	Reverse_Transcriptase	Telomerase	Telomerase activity was recently shown to be an independent prognostic factor in neuroblastoma.  Telomerase activity and gene expression of telomerase subunits in neuroblastoma tissues are associated with significantly reduced event-free and overall survival. (from J Clin Oncol 2000;18:2582-2592 (via Medscape)
C17471	Youth	Conceptual_Entities	Youth|Youth 10-21	The time of life between childhood and maturity.  This period overlaps with adolescence.
C17472	Acylaminoacyl-Peptidase	Protease	Acylaminoacyl-Peptidase|ACPH|APEH|APH Protein|Acylamino-Acid-Releasing Enzyme|Acylpeptide Hydrolase|EC 3.4.19.1|N-formylmethionine aminopeptidase	Active at neutral pH. Several variants of this enzyme exist; the human erythrocyte enzyme is relatively specific for removal of N-acetylalanine from peptides. Displays dipeptidyl-peptidase activity on glycyl-peptides, perhaps as a result of mis-recognition of the glycyl residue as an uncharged N-acyl group. Inhibited by diisopropyl fluorophosphate. In peptidase family S9 (prolyl oligopeptidase family). [EC 3.4.19.1 created 1978 as EC 3.4.14.3, transferred 1981 to EC 3.4.19.1] (from IUBMB)
C17473	E1A_Protein	Adenovirus_Protein	E1A Protein|Adenovirus E1A Protein	Proteins transcribed from the E1A region of adenovirus which are involved in positive regulation of transcription of the early genes. (MSH2001)
C17474	E1B_Protein	Adenovirus_Protein	E1B Protein|Adenovirus E1B Protein	Human E1B protein (175 aa, 20 kDa) protein is encoded by the human adenovirus 2 (HadV-2) gene. This protein is transcribed by the E1B region of the HadV-2 gene, which is involved in the regulation of E1B protein levels. This protein is an inhibitor of apoptosis induced by TNF or FAS pathways, as well as p53-mediated apoptosis. Without E1B function, virus production is compromised due to the premature death of the host cell.
C17475	AXL_Protein	Receptor_Tyrosine_Kinase	AXL Protein|AXL|Tyrosine-Protein Kinase Receptor UFO	AXL protein is a transmembrane receptor tyrosine kinase with novel structure, is evolutionarily conserved among vertebrate species, and is widely expressed in monocytes and macrophages but not in B- or T-lymphocytes.  The transforming capacity of AXL results from over expression, rather than from structural mutation.  Although normal AXL function is unknown, the transforming activity of AXL demonstrates that the receptor can drive cell proliferation. Growth arrest-specific gene-6 is an AXL stimulatory factor.  (from OMIM 109135 and NCI)
C17476	B-RAF_Protein_Kinase	Serine-Threonine_Protein_Kinase	B-RAF Protein Kinase|B-RAF Serine/Threonine Protein Kinase|BRAF|BRAF Protein|BRAF1 Protein|KRAB Protein|RAFB1 Protein	The 94 kD B-RAF serine/threonine protein kinase is a signaling factor critical for formation of the vascular system.  Fusion of TIF1A to B-RAF results in production of a TIF1-alpha-B-RAF oncoprotein.  The BRAF gene encodes the human homologue of the avian c-Rmil proto-oncogene.  (from OMIM 164757 and NCI)
C17477	BCR_Protein	GTPase-Activating_Protein	BCR Protein|ALL|BCR|BCR1|Breakpoint Cluster Region Protein|CML|D22S11|D22S662|PHL	The 160 kD BCR phosphoprotein exhibits a unique serine/threonine kinase activity, at least two SH2 binding sites, and a C-terminal GTPase activating domain for p21(rac).  The Philadelphia translocation produces a BCR-ABL1 chimeric product required for induction and maintenance of leukemia.  (from OMIM 151410 and NCI)
C17478	Beta_Catenin	Signaling_Protein	Beta Catenin|Beta-Catenin|CTNNB1|CUL-2|Cadherin-Associated Protein, Beta|Cadherin-Associated Protein, Beta 1 (88kD)|Catenin, Beta-1|Cullin 2 Protein|Cullin Homolog 2|PRO2286	Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete. (from OMIM)
C17479	Human_Chorionic_Gonadotropin_Beta_Subunit	Protein_Complex_Subunit	Human Chorionic Gonadotropin Beta Subunit|CG-Beta|CGB3|Choriogonadotropin Beta Chain|Chorionic Gonadotrophin Beta Subunit|Chorionic Gonadotropin Beta 3 Subunit|Chorionic Gonadotropin Beta Chain|Chorionic Gonadotropin Beta Polypeptide|hCG-Beta|hCGBeta	Contiguous with the LH beta subunit gene on chromosome 19q13.3, six homologous genes arranged in tandem and inverted pairs encode the beta subunit of Chorionic Gonadotropin (Glycoprotein Hormone Beta Family).Glycoprotein hormones are heterodimers of a common alpha subunit and a unique beta subunit that confers biological specificity. Produced by placental trophoblasts, Chorionic Gonadotropin stimulates ovarian steroid synthesis essential for maintenance of pregnancy. (NCI)
C17480	BMI1_Protein	Transcription_Factor	BMI1 Protein|BMI1|DNA Binding Protein BMI-1|Leukemia Viral BMI-1 Oncogene Homolog|Polycomb Complex Protein BMI-1	Involved in transcriptional repression, BMI1 heritably modifies chromatin, changing its expressibility. BMI1 may repress HOX genes as part of the Polycomb Complex to regulate segmental identity. BMI1 contains a ring-type, putative zinc finger and Polycomb-Group homology domain. BMI1 may complex with RING1. (from SWISS-PROT P35226, OMIM 164831, and NCI)
C17481	ETS1_Protein	ETS_Family_Protein	ETS1 Protein|ETS1|c-Ets-1	A member of the ETS family of transcription factors, ETS1 Protein is a set of 42-52 kD nuclear phosphoproteins that activate transcription by interaction with purine-rich sequences in gene promoter/enhancer regions.  (from OMIM 164720 and NCI)
C17482	ETS2_Protein	ETS_Family_Protein	ETS2 Protein|ETS2|c-Ets-2	A member of the ETS family of transcription factors, ETS2 Protein activity is potentiated by signaling through the RAS-RAF-MEK kinase cascade and inhibited by direct interaction with the HLH ID1 protein.  (from OMIM 164740 and NCI)
C17483	p55-FGR	SRC_Family_Tyrosine_Kinase	p55-FGR|FGR|c-FGR Protein	p55-FGR tyrosine kinase contains an SH2 domain, an SH3 domain and belongs to the SRC subfamily.  (from OMIM 164940, Swiss-Prot P09769, and NCI)
C17484	RAF-1_Protein	Mitogen-Activated_Protein_Kinase	RAF-1 Protein|RAF1|RAF1 Kinase	A serine/threonine kinase involved in cellular signal transduction. Raf is a component of a signal transduction pathway leading to increased gene expression through the c-Jun DNA binding site.
C17485	Vitamin-D3_Receptor	Steroid_Hormone_Receptor	Vitamin D3 Receptor|1,25-Dihydroxyvitamin D3 Receptor|Cholecalciferol Receptor|Receptors, Calcitriol|VDR	Vitamin D3 Receptors are cytoplasmic polypeptides that specifically bind 1,25(OH)2D3, migrate to the nucleus, and regulate transcription of specific target genes to produce a variety of biologic effects.  The VDR protein belongs to the steroid superfamily of trans-acting transcriptional regulatory factors and is most closely related to the thyroid hormone receptors.  VDR residues immediately N-terminal of the first DNA-binding zinc finger are vital for contact with TFIIB.  (from OMIM 601769 and NCI)
C17486	CCAAT_Enhancer_Binding_Protein	Enhancer_Binding_Protein	CCAAT Enhancer Binding Protein|C/EBP	A protein which binds to enhancers having a conserved CCAAT sequence.
C17487	Fc-Gamma_Receptor-III	Fc_Receptor	Fc-Gamma Receptor III|CD16	Fc-Gamma Receptor III is expressed on natural killer cells, granulocytes, and monocytes.  It is included in the zeta natural killer cell receptor complex.  Fc receptor III is encoded by two separate genes: one for the neutrophil receptor (CD16) and another for the receptor on natural killer cells and macrophages.  Some gamma-delta T-cells express CD16.  Mitogenic stimulation of circulating gamma-delta T-cells results in decreased expression of CD16.  (from OMIM 146740 and NCI)
C17488	CD14_Antigen	Cell_Adhesion_Molecule	CD14 Antigen|CD14|Lipopolysaccharide Receptor|Myeloid Cell-Specific Leucine-Rich Glycoprotein	CD antigen expressed on surface of monocytes, macrophages, eosinophils, neutrophils; lipopolysaccharide receptor; signals production of tumor necrosis factor.
C17489	Cytotoxic_T-Lymphocyte-Associated_Protein-4	Cell_Surface_Receptor	Cytotoxic T-Lymphocyte-Associated Protein 4|CD152|CD152 Antigen|CTLA-4|CTLA4|CTLA4 Protein|CTLA4-TM|Cytotoxic T-Lymphocyte Protein 4|Cytotoxic T-Lymphocyte-Associated Antigen 4|Cytotoxic T-Lymphocyte-Associated Serine Esterase-4	CTLA-4 is an inhibitory T-cell surface receptor for B7 ligands on antigen presenting cells. It contains an extracellular V-like domain, a transmembrane region, and a putative cytoplasmic domain. It shares significant homology with CD28. Both bind the same ligands, however CTLA-4 binds to B7 with a greater affinity. B7 antigen-presenting cells regulate T-cell activation by delivering antigen-independent stimulatory signals through CD28 and inhibitory signals through CTLA-4. While CD28 is on the membrane of resting T-cells, CTLA-4 is detectable only on cells activated after antigen presentation. A CTLA-4 splice variant with a deleted transmembrane segment is preferentially expressed in non-activated T-cells. Activation of lymphocytes results in the disappearance of sCTLA-4 followed by its gradual reappearance, whereas CTLA-4 increases after activation. CTLA-4 may play an inhibitory role in regulating lymphocyte expansion. (from OMIM 123890 and NCI)
C17490	Cyclin_E	Retired_Concepts	Cyclin E
C17491	E-Selectin	Selectin	E-Selectin|CD62E|Cell Adhesion Molecule E-Selectin|ELAM|ELAM1|ESEL|Endothelial Adhesion Molecule 1|Endothelial Leukocyte Adhesion Molecule 1|LECAM2|Leukocyte Endothelial Cell Adhesion Molecule 2|SELE	Cell adhesion molecule and CD antigen that mediates neutrophil, monocyte, and memory T-cell adhesion to cytokine-activated endothelial cells. E-selectin recognizes sialylated carbohydrate groups related to the Lewis X or Lewis A family.
C17492	FAT_Protein	Cell_Adhesion_Molecule	FAT Protein|Cadherin Family Member 7|Cadherin ME5|Cadherin-Related Tumor Suppressor|FAT	The gene encoding this protein is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. This protein is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. (from LocusLink)
C17493	GATA-1	GATA-Binding_Protein	GATA-1|ERYF1|Erythroid Transcription Factor|Erythrold Transcription Factor 1|GATA Binding Protein 1|GATA1|GF1|Globin Transcription Factor 1|NFE1|Transcription Factor GATA1	A zinc-finger transcription factor that binds to GATA elements in regulatory regions of globin and other erythroid-specific genes.  Also known as GF-1, NF-E1 and Eryf 1.  Its expression is restricted to a subset of hematopoietic cells.
C17494	Guanine_Nucleotide_Exchange_Factor	Signaling_Protein	Guanine Nucleotide Exchange Factor|GDP Exchange Factors|GDP-GTP Exchange Factors|GEF|Guanine Nucleotide-Exchange Factor|Guanine Nucleotide-Releasing Factor|Guanyl-Nucleotide Exchange Factor|Guanyl-Nucleotide Releasing Factor	GEFs.  Proteins that catalyze the release and exchange of GDP for GTP from GTP-binding regulatory proteins, which are active in the GTP-bound form.  The prototypical GEF is the eukaryotic initiation factor 2b, eIF-2B.  Among other GTP-binding proteins regulated in this manner is p21 ras.
C17495	Ephrin_Receptor-EphA3	Ephrin_Receptor	Ephrin Receptor EphA3|EPA3|EPH-Like Tyrosine Kinase 1|EPHA3|Ephrin Type-A Receptor 3|HEK|Human Embryo Kinase 1|Tyrosine Protein Kinase Receptor ETK1	The HEK receptor tyrosine kinase shows a high degree of homology with EPH and ELK RTKs.  The largest subfamily of RTKs, EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. EPH-family receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. EPH receptors are divided into two groups based on their extracellular domain sequences and affinities for ephrin-A (EPHA) and ephrin-B ligands (EPHB). HEK expression appears restricted to lymphoid tumor cell lines, suggesting that HEK may contribute to lymphoid malignancies and normal lymphoid function and differentiation. (from OMIM 179611 and NCI)
C17496	Hh-1_Antigen	Mouse_Protein	Hh-1 Antigen|Hematopoietic Histocompatibility-1|Hemopoietic Histocompatibility-1	the products of "hybrid histocompatibility" (Hh) loci, responsible for the phenomenon known as hybrid resistance. (from Fundamental Immunology, 3rd ed., William Paul, ed., Raven Press, NY 1993, pg 1104-1105)
C17497	HOX11_Protein	Homeobox_Protein	HOX11 Protein|HOX11|Homeo Box 11|Homeobox Protein HOX11|T-Cell Leukemia 3 Protein|T-Cell Leukemia Homeobox Protein 1|TCL3 Protein|TLX1	a DNA-binding nuclear transcription factor.  HOX11 is an orphan homeobox gene since it is located at a site outside the 4 mammalian HOX clusters. Whereas the orthodox HOX genes encode a combinatorial system of positional specification along the anterior-posterior axis of the embryo, the function of orphan homeobox genes is less well understood.  Essential for the survival of splenic precursors during organogenesis. (from OMIM)
C17498	Papillomavirus_Type_8_Protein-E7	Papillomavirus_Transforming_Protein-E7	Oncogene Protein E7 Human Papillomavirus Type 8
C17499	Papillomavirus_Type_18_Protein-E2	Papillomavirus_Protein-E2	Oncogene Protein, E2 Human Papillomavirus Type 18
C17500	Papillomavirus_Type_16_Protein-E5	Viral_Oncogene_Protein	Human Papillomavirus Type 16 E5 Protein	The E5 protein of the Human Papillomavirus encodes a short hydrophobic peptide, which appears to alter the turnover rate of the EGF receptor in keratinocytes, thereby enhancing their growth. (Virology 280:169-75, 2001)
C17502	Papillomavirus_Type_16_Protein-E4	Papillomavirus_Protein-E4	Human Papillomavirus Type 16, E4 Protein
C17503	Intercellular_Adhesion_Molecule-2	Cell_Adhesion_Molecule	Intercellular Adhesion Molecule 2|CD102|CD102 Antigen|ICAM-2|ICAM2	CD102.  Intracellular Adhesion Molecule-2.
C17504	Intercellular_Adhesion_Molecule-3	Cell_Adhesion_Molecule	Intercellular Adhesion Molecule 3|CD50|CD50 Antigen|ICAM-3|ICAM3	ICAM3 is a ligand for LFA-1, a major receptor of T-cells, B-cells, and granulocytes that mediates the leukocyte adhesion reactions underlying many immune functions.  The interaction of LFA-1 with ICAM provides essential accessory adhesion signals in many immune interactions, including those between T- and B-lymphocytes and cytotoxic T-cells and their targets.  ICAM3 is potentially the most important ligand for LFA-1 in the initiation of the immune response.  ICAM3 is closely related to ICAM1, consists of five Ig domains, and binds LFA-1 through its two N-terminal domains.  (from OMIM 146631 and NCI)
C17505	Insulin-Like_Growth_Factor-Binding_Protein-1	Insulin-Like_Growth_Factor-Binding_Protein	Insulin-Like Growth Factor-Binding Protein 1|AFBP|Alpha-Pregnancy-Associated Endometrial Globulin|Amniotic Fluid Binding Protein|Binding Protein-25|Binding Protein-26|Binding Protein-28|Growth Hormone Independent-Binding Protein|IBP-1|IGF Binding Protein 1|IGFBP-1|IGFBP1|Insulin-Like Growth Factor Binding Protein 1|PP12|Placental Protein 12	Encoded by human IGFBP1 Gene and expressed in liver, endometrium, and decidua, low molecular weight secreted 259-aa 29-kD Insulin-Like Growth Factor-Binding Protein 1 precursor contains an IGFBP domain and a thyroglobulin type-I domain. IGFBP1 binds equally to plasma IGF I and IGF II with high affinity. The protein has 15 N- and C-terminal cysteines and a C-terminal RGD sequence that may promote potentiation of IGF I biologic actions. IGFBP1 is probably phosphorylated by casein kinase II, which alters IGF affinity. IGF-binding proteins prolong the half-life of IGFs and alter IGF interactions with cell surface receptors. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C17506	Insulin-Like_Growth_Factor-Binding_Protein-2	Insulin-Like_Growth_Factor-Binding_Protein	Insulin-Like Growth Factor-Binding Protein 2|IBP-2|IBP2|IGF Binding Protein 2|IGF-BP53|IGFBP-2|IGFBP2|Insulin-Like Growth Factor Binding Protein 2|Insulin-Like Growth Factor Binding Protein 2 (36kD)|Insulin-Like Growth Factor Binding Protein 2, 36kDa	Encoded by human IGFBP2 Gene, cysteine-rich high molecular weight secreted 328-aa 35-kD Insulin-Like Growth Factor-Binding Protein 2 precursor contains an IGFBP domain and a thyroglobulin type-I domain. IGF-binding proteins prolong plasma IGF half-life and alter IGF interaction with cell surface receptors. The predominant form in plasma (150-kD) contains IGF-BP53 with apparent molecular mass of 53-kD. IGFBP2 binds IGF-II with high affinity more than IGF-I. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C17507	Insulin-Like_Growth_Factor-Binding_Protein-4	Insulin-Like_Growth_Factor-Binding_Protein	Insulin-Like Growth Factor-Binding Protein 4|IGF Binding Protein 4|IGFBP-4|IGFBP4|Insulin-Like Growth Factor Binding Protein 4	IGFBP4 belongs to the IGFBP family. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. Secreted IGFBPs prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs. They alter the interaction of IGFs with cell surface receptors. IGFBP4 contains a thyroglobulin type-I domain and binds IGF-II more than IGF-I. IGFBP4 inhibits IGF-induced bone cell proliferation. (from OMIM 146733, SWISS-PROT P22692, and NCI)
C17508	Insulin-Like_Growth_Factor-Binding_Protein-5	Insulin-Like_Growth_Factor-Binding_Protein	Insulin-Like Growth Factor-Binding Protein 5|IGF Binding Protein 5|IGFBP-5|IGFBP5|Insulin-Like Growth Factor Binding Protein 5	IGFBP5 contains a thyroglobulin type-I domain and belongs to the IGFBP family.  IGFBPs display strong sequence homologies.  IGFBPs contain three distinct domains. N-terminal domain 1 and C-terminal domain 3 contain invariant cysteine residues and are thought to be the IGF binding domains.  Domain 2 generally lacks sequence identity among the IGFBPs.  Domain 3 is homologous to the thyroglobulin type I repeat.  IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs.  IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis; the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism.  Secreted IGF-binding proteins prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs; they alter the interaction of IGFs with cell surface receptors.  (from OMIM 146734, SWISS-PROT P22692, and NCI)
C17509	Insulin-Like_Growth_Factor-Binding_Protein-3	Insulin-Like_Growth_Factor-Binding_Protein	Insulin-Like Growth Factor-Binding Protein 3|IGF Binding Protein 3|IGFBP-3|IGFBP3|Insulin-Like Growth Factor Binding Protein 3	IGFBP3 belongs to the IGFBP family. IGFBP3 functions as the major carrying protein for IGF1 and IGF2 in the circulation, modulates IGF activity, and inhibits cell growth. IGFBP3 binds IGF-II more than IGF-I. Endothelial IGFBP3 forms a ternary complex with IGF-I or IGF-II and an 85 kD glycoprotein (ALS). IGFBP3 levels increase in the presence of IGF-I, insulin and other growth-stimulating factors such as growth hormone, epidermal growth factor, and phorbol esters. IGFBP3 may control angiogenesis and cell responses in the corpus luteum by autocrine/paracrine mechanisms. IGFBP3 also possesses growth-inhibitory and -potentiating effects that are independent of IGF and are mediated through specific receptors. As a specific IGFBP3-binding protein, transferrin blocks IGFBP3-induced cell proliferation and IGFBP3-induced apoptosis. (from OMIM 146732, SWISS-PROT P17936, and NCI)
C17510	WNT2_Protein	WNT_Family_Protein	WNT2 Protein|INT-1 Related Protein|IRP|IRP Protein|WNT2|WNT2 Gene Product	The WNT2 protein is a secreted growth factor member of the INT1 gene family and is associated with breast cancer.  WNT2 is expressed in a variety of fetal and adult human tissues.  (from OMIM 147870 and NCI)
C17511	L-Plastin	Actin-Binding_Protein	L-Plastin|LC64P|LCP1|Lymphocyte Cytosol Polypeptide 64-KD|Lymphocyte Cytosolic Protein 1|Plastin 2	L-Plastin is an actin-binding lymphocyte cytosolic protein identical to p65, an IL2-stimulated phosphoprotein in T-cells.  It contains two EF-hand calcium-binding domains, a calmodulin-binding site, and two tandem actin-binding domains.  (from OMIM 153430 and NCI)
C17512	Selectin-L	Selectin	Selectin L|L-Selectin|Lymph Node Homing Receptor|Lymphocyte Adhesion Molecule 1|SELL	L-Selectin is a cell surface glycoprotein adhesion molecule that serves as a homing receptor for lymphocytes to lymph node high endothelial venules.  The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to C3/C4 binding protein consensus repeat units.  L-Selectin may also play a role in neutrophil adhesion to endothelium at sites of inflammation.  A tissue-specific mucin-like endothelial glycoprotein appears to function as ligand for L-selectin, in the role of scaffold that presents carbohydrates to the L-selectin lectin domain.  PLAUR is directly associated with the carbohydrate-binding domain of L-selectin in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins.  (from OMIM 153240 and NCI)
C17513	MAGE-3-1_Antigen	Protein_with_Unknown_or_Unclassified_Function	MAGE-3.1 Antigen|MAGE-3|MAGE-3 Antigen|MAGEA3	Expressed only in normal testis and placenta by human MAGEA3 Gene, MAGE-3.1 Antigen has an unknown function. (NCI)
C17514	MCC_Protein	Protein_with_Unknown_or_Unclassified_Function	MCC Protein|CRCM Protein|Colorectal Mutant Cancer Protein|MCC	MCC is a candidate for the putative colorectal tumor suppressor gene. (from LocusLink)
C17515	MDM2_Protein	Ligand_Binding_Protein	MDM2 Protein|Double Minute 2 Protein|HDM2|MDM 2 Protein|MDM2|Ubiquitin-Protein Ligase E3 MDM2|p53 Binding Protein|p53-Binding Protein MDM2	Inhibits p53 trans-activation, cell cycle arrest, and apoptosis. MDM2 binds p53 in the cell cycle at S/G2M phase and targets p53 for proteasome-mediated proteolysis. MDM2 also inhibits Rb protein and binds p14(ARF), ribosomal protein L5, and specifically to RNA. MDM2 gene expression is induced by DNA damage and regulated by the Ras-MAP kinase pathway. Some soft tissue sarcomas carry amplified MDM2 and overexpress MDM2 protein. (from SWISS-PROT Q00987, OMIM 164785, and NCI)
C17516	APEH_Gene	Hydrolase_Gene	APEH Gene|ACPH|APEH|APH|D3S48E|MGC2178|N-Acylaminoacyl-Peptide Hydrolase Gene|OPH	Human APEH Gene (S9 Peptidase Family) encodes Acylaminoacyl-Peptidase, active at neutral pH. Several variants of this enzyme exist; the human erythrocyte enzyme is relatively specific for removal of N-acetylalanine from peptides. APEH displays dipeptidyl-peptidase activity on glycyl-peptides, perhaps as a result of mis-recognition of the glycyl residue as an uncharged N-acyl group. APEH is inhibited by diisopropyl fluorophosphate. (NCI)
C17517	Nuclear_Matrix_Protein	Structural_Protein	Nuclear Matrix Protein	Proteins that give shape to the nucleus and provide support for the chromosomes.
C17518	Papillomavirus_Type_6_Protein-E4	Papillomavirus_Protein-E4	Oncogene Protein E4, Papillomavirus Type 6
C17519	Papillomavirus_Type_11_Protein-E4	Papillomavirus_Protein-E4	Oncogene Protein E4, Papillomavirus Type 11
C17520	Papillomavirus_Type_18_Protein-E6	Papillomavirus_Transforming_Protein-E6	Oncogene Protein E6, Human Papilloma Virus Type 18
C17521	OTF-1	Homeobox_Protein	OTF-1|Lymphoid-Specific OTF 1|NF-A1|NF-III|Nuclear Factor III|OCT-1|Octamer Transcription Factor-1|Octamer-Binding Transcription Factor 1|POU Domain, Class 2, Transcription Factor 1|POU2F1	Encoded by human POU2F1 Gene (POU2 Family), ubiquitous transcription factor OTF-1 contains one homeobox domain, binds to the octamer ATTTGCAT motif, and activates genes for some snRNA, histone H2B, and immunoglobulins. POU domain proteins contain a bipartite DNA-binding domain divided by a flexible linker that enables diverse monomeric configurations on DNA; additional versatility is conferred by dimerization. OTF-1 POU dimers on palindromic OCT factor recognition elements, or PORE, (ATTTGAAATGCAAAT) can recruit transcriptional coactivator OBF1. OTF-1 interacts with transcription activators NR3C1, AR, and PGR. (from LocusLink, Swiss-Prot, and NCI)
C17522	P-Selectin	Selectin	P-Selectin|CD62|GMP-140|GMP140|SELP	P-Selectin is a cell surface adhesion molecule that mediates the interaction of activated endothelial cells or platelets with neutrophils and monocytes.  The protein is detected in megakaryocytes and platelets, as well as in vascular endothelial cells, but not in other cell types.  In endothelia, the protein is localized to the membranes of Weibel-Palade bodies, intracellular storage granules for von Willebrand factor.  CD24 is a ligand for P-selectin.  Sorting nexin-17 interacts with the cytosolic domain of P-selectin and may function in the intracellular trafficking of P-selectin.  (from OMIM 173610 and NCI)
C17523	Papillomavirus_Enhancer-Associated_Factor	Viral_Protein	Papillomavirus Enhancer-Associated Factor
C17524	Junction_Plakoglobin	Cell_Adhesion_Molecule	Junction Plakoglobin|Desmoplakin III|Gamma Catenin|Gamma-Catenin|JUP|Plakoglobin	Plakoglobin (gamma-Catenin) is a major soluble and membrane-associated cytoplasmic protein common to desmosomes and intermediate junctions.  It associates with the cytoplasmic region of Desmoglein I and mediates the connection of cadherins to actin filaments and to other transmembrane and peripheral cytoplasmic proteins in epithelial adherens junctions.  The cadherin-catenin complex interacts with EGFR; beta-Catenin and Plakoglobin are tyrosine phosphorylated by activated EGFR.  APC binds to and regulates beta- and gamma-Catenin.  Homologues of Drosophila armadillo, beta-Catenin and gamma-Catenin have analogous structures and functions in cell adhesion and the WNT signaling pathway.  Several mutations of gamma-Catenin have transforming activity dependent on TCF/LEF and c-MYC function.  Beta- and gamma-Catenin may have distinct roles in WNT signaling via differential effects on downstream target genes.  (from OMIM 173325 and NCI)
C17525	Prostate-Specific_Antigen	Kallikrein	Prostate-Specific Antigen|Antigen, Prostate-Specific|EC 3.4.21.34|Fletcher Factor|Gamma-Seminoprotein|KLK3|Kallikrein 3|Kininogenin|P-30 Antigen|PSA|Plasma Kallikrein Precursor|Plasma Prekallikrein|Prostate Specific Antigen|Prostate Specific Antigen Preproprotein|Semenogelase|Seminin|prostate-specific antigen	Alternate isoforms of the single-chain 261-aa 30-kD Kallikrein 3 (Prostate Specific Antigen) glycoprotein precursor are encoded by human KLK3 Gene (Kallikrein Family). Frameshifted isoform 2 has a shorter distinct C-terminus. A Kallikrein-like serine protease in seminal plasma, PSA may function in liquefaction of seminal coagulum by (preferential Tyr-X) cleavage of seminal vesicle protein. Kallikrein proteases have diverse functions. Mounting evidence implicates kallikreins in carcinogenesis; some have potential as cancer biomarkers. The serum level of PSA is useful in diagnosis and monitoring of prostatic carcinoma, benign prostate hyperplasia, or infection or inflammation of the prostate. (NCI)
C17526	Farnesyl_Protein_Transferase	Protein_or_Riboprotein_Complex	Farnesyl Protein Transferase|Farnesyl Transferase|Farnesyltransferase|Protein Farnesyltransferase	A heterodimeric enzyme (alpha and beta subunits) that catalyzes the addition of farnesyl groups, as farnesyl diphosphate, to the C termini of proteins.
C17527	Papillomavirus_Type_16_Protein-L1	Capsid_Protein	Protein L1, Type 16 Human Papillomavirus	A papillomavirus capsid protein
C17528	CSK_Protein_Kinase	Protein_Tyrosine_Kinase	CSK Protein Kinase|CSK|CYL Protein Tyrosine Kinase|EC 2.7.1.112|Protein-Tyrosine Kinase CYL|Tyrosine-Protein Kinase CSK|c-src Kinase|c-src Tyrosine Kinase	CSK is a novel cytoplasmic tyrosine kinase that down regulates the tyrosine kinase activity of c-src oncoprotein through phosphorylation of the c-src carboxy terminus.  Since cell transformation by SRC oncoproteins is caused by mechanisms that interfere with this phosphorylation, CSK might function as an antioncogene.  The CSK gene is ubiquitously expressed.  The SH3 domain of CSK associates with a proline-rich region of PEP, a protein-tyrosine phosphatase expressed in hemopoietic cells.  This association is highly specific; PEP may be an effector and/or regulator of CSK in T-cells and other hemopoietic cells.  (from OMIM 124095 and NCI)
C17529	Qa-1_Antigen	Mouse_Protein	Qa-1 Antigen|H-2Q1|Qa-1|Qa1|Qed-1	A sub-type of MHC Class I
C17530	Insulin-Like_Growth_Factor_Receptor	Growth_Factor_Receptor	Insulin-Like Growth Factor Receptor|IGF Receptor	The protein on surface of target cells specific for binding IGF.  There are two types of IGF receptor, one of which closely resembles the insulin receptor.
C17531	Insulin-Like_Growth_Factor-1_Receptor	Insulin-Like_Growth_Factor_Receptor	Insulin-Like Growth Factor 1 Receptor|IGF-I Receptor|IGF1R|Insulin-Like-Growth Factor I Receptor|Receptors, Insulin-Like-Growth Factor I	Human insulin-like growth factor-1 receptor protein (1367 aa, 155 kDa precursor) is encoded by the human insulin-like growth factor-1 (IGFR1) gene. This membrane-bound protein, a disulfide-linked alpha2/beta2 tetramer, binds both insulin growth factors I and II.  Ligand binding activates protein kinase activity, controls cell cycle progression and enhances cell survival.
C17532	Retinoic_Acid_Receptor	Retinoid_Receptor	Retinoic Acid Receptor|RAR	Retinoid receptors (RARA, RARB, RARG) require co-regulators to increase selective binding to DNA response elements in target genes and enhance transcriptional activity.
C17533	Retinoic_Acid_Receptor_Alpha	Retinoic_Acid_Receptor	Retinoic Acid Receptor Alpha|RARA|RARalpha	A protein that binds retinoic acid with high affinity, RAR alpha is homologous to the steroid receptor superfamily and a retinoic acid-inducible transacting enhancer factor. There are at least two retinoic acid receptors, RAR alpha and RAR beta. Binding of ligand to receptors attracts co-activator proteins containing a NR box. NCOR1 and SMRT contain CoRNR box sequences, similar to the NR box, in receptor interaction domains and mediate inhibition of gene transcription by RARs. Sequences flanking the CoRNR box determine receptor specificity.  Differential recognition of receptors by co-activators and co-repressors is due to subtle differences between CoRNR and NR boxes. The association of SMRT with receptors is destabilized by ligand, triggering the activation process. The repressor function of SMRT may promote interaction with transcription factor TFIIB. (from OMIM 180240 and NCI)
C17534	Retinoid-X_Receptor	Retinoid_Receptor	Retinoid X Receptor|RXR|Retinoic Acid Receptor RXR	Human nuclear Retinoid X Receptors RXRA, RXRB, and RXRG (NR2/RXR Family) are transcriptional regulators composed of N-terminal modulating domain, DNA-binding domain (AGGTCA response elements), and C-terminal 9-cis RA-binding domain. RXR homodimers and RXR/RAR heterodimers mediate distinct retinoic acid response pathways.  RXRs also interact with TH- and vitamin D receptors, and with NCOA3, NCOA6, PML, and PPARG coactivators; and mediate RA biological effects by binding to specific target gene promoters and inducing target gene transcription. RXRs/LXRs and RXRs/FXR may mediate cholesterol homeostasis, by governing cholesterol transport from peripheral cells, inhibiting cholesterol absorption in the small intestine, and repressing bile acid synthesis through upregulation of ABC1 and repression of CYP7A1 expression. (NCI)
C17535	RGD_Receptor	Cell_Adhesion_Molecule	RGD Receptor	Class of divalent cation-dependent receptors that recognizes sequence Arg-Gly-Asp in adhesive protein; examples are fibronectin & vitronectin receptors.
C17536	Sodium-Iodide_Symporter	Transport_Protein	Sodium-Iodide Symporter|NIS|SLC5A5	An integral membrane transport protein.  Expression of the sodium/iodide symporter (NIS) is high in lactating mammary tissue and in over 80% of breast cancers, but is not found in normal breast tissue. This suggests that radioactive iodine could be useful in diagnosing or treating breast cancers.
C17537	SPT5_Protein	Protein_Complex_Subunit|Transcription_Repressor_Corepressor	SPT5 Protein|Chromatin Structure Regulator Homolog|SUPT5H|SUPT5H Gene Product|Suppressor of TY 5 Homolog|Transcription Initiation Protein SPT5	Believed to be part of a transcriptional-repression protein complex involved in modulating chromatin structure. The SPT5 amino terminus is highly acidic, while the C-terminus contains seven Mitogen-Activated Protein (MAP) Kinase consensus sequences. (OMIM 602102 and NCI)
C17538	T4_Endonuclease-V	Viral_Protein	T4 Endonuclease V|Dimericine|Endonuclease V|T4 Endonuclease 5|T4N5	A DNA repair enzyme from bacteriophage T4.  It catalyzes the first reaction step of the excision repair pathway to remove pyrimidine-dimers produced within duplex DNA by UV irradiation.  It has been incorporated into a topical lotion for treatment of xeroderma pigentosum.
C17539	OTF-2	Homeobox_Protein	OTF-2|Lymphoid-Restricted Immunoglobulin Octamer Binding Protein NF-A2|Lymphoid-Specific OTF2|OCT-2|Octamer Transcription Factor-2|Octamer-Binding Transcription Factor 2|POU Domain, Class 2, Transcription Factor 2|POU Homeodomain Transcription Factor 2|POU2F2	Encoded by human POU2F2 Gene (POU2 Family), alternative isoforms 1 (478-aa, 51-kD), 2 (466-aa), 3 (462-aa), and 4 (399-aa) of transcription factor OTF-2 contain a DNA binding homeobox domain, bind to octamer motif ATTTGCAT, and regulate Ig gene expression and transcription in several other tissues. OTF-2 also interacts with transcription activators NR3C1, AR, and PGR. Neuronal NOS gene is a target of OTF-2. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C17540	TFIID	Basal_Transcription_Factor	TFIID|TF2D|Transcription Factor IID	TFIID is a DNA-binding protein complex required for RNA polymerase II-mediated transcription of many, if not all, protein-encoding genes in eukaryotic cells. TFIID plays a key role in initiation, since it binds to the TATA element to form a complex that nucleates the assembly of the other components into a preinitiation complex. TFIID interacts with TFIIA, which may stabilize its binding. A reinitiation intermediate including TFIID can act as a scaffold for formation of a functional reinitiation complex. TFIID also links the control of transcription to the cell cycle. The DNA-binding subunit of TFIID is the TATA box-binding protein (TBP) that interacts primarily within the minor groove of the DNA helix. The largest subunit of TFIID is TAF1, which can autophosphorylate and transphosphorylate the large subunit of the basal factor TFIIF. (From OMIM and NCI)
C17541	TFIIIB	Basal_Transcription_Factor	TFIIIB|B-TFIID|Transcription Factor IIIB	The RNA polymerase III initiation factor TFIIIB is assembled onto DNA through interactions involving the Tfc4 subunit of the assembly factor TFIIIC and two subunits of TFIIIB, Brf1 and Bdp1.
C17542	TIMP-2	Tissue_Inhibitor_of_Metalloproteinases	TIMP-2|CSC-21K|Metalloproteinase Inhibitor 2|Tissue Inhibitor-of Metalloproteinase-2	Encoded by constitutive human TIMP2 Gene (TIMP Family), 207-aa 28-kD secreted TIMP-2 protein contains 12 cysteines and 3 conserved tryptophans. Activity dependent on disulfide bonds, TIMP-2 complexes with and inactivates matrix metalloproteinases involved in extracellular matrix degradation and connective tissue remodeling. TIMP family members may possess selective affinities for matrix metalloproteinases and TIMP-2 may play a different role from TIMP-1 or TIMP-3. TIMP-2 inhibits type IV collagenase in a stoichiometric fashion and acts on MMP-1, -2, -3, -7, -8, -9, -10, -13, -14, -15, -16 and -19. The N-terminus is responsible for MMP inhibition; the C-terminus mediates specific molecular functions. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C17543	TIMP-1	Tissue_Inhibitor_of_Metalloproteinases	TIMP-1|Collagenase Inhibitor|EPA|Erythroid Potentiating Activity|Erythroid Potentiating Activity, Collagenase Inhibitor|Fibroblast Collagenase Inhibitor|Metalloproteinase Inhibitor 1|Tissue Inhibitor of Metalloproteinase 1|Tissue Inhibitor of Metalloproteinases	Encoded by human TIMP1 Gene (TIMP Family) TIMP-1 expression in platelets and macrophages is highly inducible by cytokines and hormones. A 207-aa 28-kD secreted glycoprotein growth factor that mediates erythropoiesis, TIMP-1 tightly complexes with and inhibits collagenase as well as connective tissue metalloendoproteases, involved in extracellular matrix degradation and connective tissue remodeling. Activity dependent on disulfide bonds, TIMP1 acts on MMP-1, -2, -3, -7, -8, -9, -10, -11, -12, -13 and -16. TIMP family members may possess selective affinities for matrix metalloproteinases. The N-terminus is responsible for MMP inhibition; the C-terminus mediates specific molecular functions. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C17544	Tissue_Inhibitor_of_Metalloproteinases	Enzyme_Inhibitor_Protein	Tissue Inhibitor of Metalloproteinases|TIMP	21-27 kDa proteins found in the extracellular matrix; regulate the activity of collagenase and therefore are important in tumorigenesis, angiogenesis, chondrosteosis, and other tissue forming processes.
C17545	AP-2_Family_Transcription_Factor	Transcription_Factor	AP-2 Family Transcription Factor|AP-2 Family Protein	Activator Protein 2.  Originally identified as a cellular transcription factor that binds the enhancer region of SV40.  It is encoded by a family of related genes, AP-2 alpha, AP-2 beta, and AP-2 gamma.  AP-2 is developmentally regulated and inducible by RET.
C17546	E2F_Transcription_Factor-1	Transcription_Factor	E2F Transcription Factor 1|E2F-1|E2F1|PBR3|PRB-Binding Protein E2F-1|RBAP-1|RBBP-3|Retinoblastoma Associated Protein 1|Retinoblastoma Binding Protein 3|Retinoblastoma-Associated Protein 1|Transcription Factor E2F	Transcription factor E2F1 binds to DNA as homo or heterodimers with DP1 or DP2. It activates p53 and p73 gene expression. MYC-induced apoptosis involves E2F1. E2F1 can induce apoptosis in a p53-independent manner by accumulation of p73 or by a death receptor-dependent mechanism via down regulating TRAF2 and inhibiting activation of NFKB anti-apoptotic signals. E2F1 induces p53-dependent apoptosis by inducing ARF, which neutralizes MDM2 and stabilizes p53. E2F is a critical determinant of G1/S transition, activating transcription of genes necessary for DNA replication. RB interacts with E2F factors to arrest cells in G1 by active transcriptional repression. RB/E2F repression mediates G1 arrest triggered by TGFB, by p16(INK4A), and by contact inhibition. Accumulation of G1 cyclins E and D1 is regulated by E2F1. TCR-AICD, in a p53-independent late G1 phase cell-cycle checkpoint, is dependent on E2F1 and TP73. (from OMIM and NCI)
C17547	Thrombospondin-1	Thrombospondin	Thrombospondin 1|THBS1|TSP|TSP-1|TSP1|Thrombospondin-1	Human thrombospondin-1 protein (1170 aa, 129 kDa precursor) is encoded by the human thrombospondin-1 (THBS1) gene. This protein, a disulfide-linked homotrimer, is an adhesive extracellular matrix glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. Thrombospondin-1 protein is also involved in cell migration and proliferation during embryogenesis and wound repair. It may be a regulator of tumor growth and metastasis.
C17548	Proteinase-3	Serine_Protease	Proteinase 3|ACPA|AGP7|Azurophil Granule Protein 7|C-ANCA|C-ANCA Antigen|Leukocyte Proteinase 3|MBT|Myeloblastin|NP-4|Neutrophil Proteinase 4|Neutrophil Serine Proteinase|PR-3|PR3|PRTN3|Serine Proteinase, Neutrophil|Wegener Autoantigen|Wegener Granulomatosis Autoantigen|p29	An elastase homolog involved in immune reactions of neutrophils and monocytes.  Stored in a specialized lysosome, the azurophil granule, it degrades elastin and other connective tissue proteins and contributes to antimicrobial defenses.  Identical to myeloblastin, it is a target of autoantibodies associated with Wegener's granulomatosis, and is known as Wegener's autoantigen.
C17549	WT1_Protein	DNA_Binding_Protein	WT1 Protein|WT1|WT1 Gene Product|WT33	A potential regulator of transcription, WT1 belongs to the EGR family of C2H2 zinc-finger proteins and binds to the DNA sequence 5'-CGCCCCCGC-3'. Inactivation of WT1 is one cause of Wilm's Tumor, an embryonal malignancy of the kidney. Defects in WT1 are also associated with Denys-Drash Syndrome (DDS) and Diffuse Mesangial Sclerosis (DMS). (from SWISS-PROT P19544, OMIM 194070, and NCI)
C17550	Hepatitis-B_X-Protein	Viral_Protein	Hepatitis B X-Protein|Hepatitis B Virus-X	Hepatitis B virus X protein; a hepatitis B viral product relevant to hepatocarcinogenesis.
C17551	Advocacy	Sociology	Advocacy	The process of defending or pleading the cause of another individual or group (from PSY94)
C17552	Ethnography	Anthropology	Ethnography	Descriptive study of cultures and societies. Used for the scientific discipline or the descriptive analyses themselves. Consider also ETHNOLOGY. (PSY94)
C17553	Clinical_Ethics	Ethics	Clinical Ethics|Ethics in Clinical Practice	The branch of ethics that studies moral values in the clinical sciences.
C17554	Transcriptional_Activation	Transcriptional_Regulation	Transcriptional Activation|Gene Activation|Transcription Activation|Up-Regulation	The process by which an unexpressed gene is activated to serve as a transcription template for synthesis of RNA.
C17555	Oncogene_JUN	JUN_Gene	Oncogene JUN|JUN|v-JUN Avian Sarcoma Virus 17 Oncogene Homolog	An oncogene from an avian sarcoma virus. The protein it encodes dimerizes with fos to form the transcription factor AP1.
C17556	Worksite	Sites_of_Care_Delivery	Worksite|Work Sites	location or environment where an individual is employed; e.g. office, laboratory, building, warehouse, etc.
C17557	Apoptosis	Cell_Death	Apoptosis|PCD|Programmed Cell Death	(ap-o-TOE-sis) A normal series of events in a cell that leads to its death.
C17558	Echo-Planar_Imaging	Magnetic_Resonance_Imaging|Magnetic_Resonance_Spectroscopic_Imaging	Echo-Planar Imaging|Medical Imaging, Planar	A type of Magnetic Resonance Imaging that uses only one nuclear spin excitation per image and therefore can obtain images in a fraction of a second rather than the minutes required in traditional MRI techniques. It is used in a variety of medical and scientific applications.(From MSH 2001).
C17559	Collagenase	Protease	Collagenase|Collagenases|collagenase	Collagenases are enzymes that degrade collagen fibers. These enzymes play an important role in connective tissue metabolism and are produced by specific cells involved in both repair and remodeling processes.
C17560	Isoprenylation	Post-Translational_Modification	Isoprenylation	The covalent addition of prenyl and multiprenyl residues to a macromolecule.
C17561	Fusion_Protein	Protein_Organized_by_Origin	Fusion Protein|Chimera Protein|Chimeric Protein|fusion protein	A protein created by joining two genes together. Fusion proteins may occur naturally or can be created in the laboratory for research.
C17562	in_situ_Hybridization	Nucleic_Acid_Hybridization	in situ Hybridization|Genetics, in situ Hybridization	Use of a DNA or RNA probe to detect the presence of complementary sequences in chromosomes, cells, or tissues
C17563	Fluorescence_in_situ_Hybridization	in_situ_Hybridization	Fluorescence in situ Hybridization|FISH	A physical mapping approach that uses fluorescent tags to detect hybridization of probes within metaphase chromosomes or less condensed somatic interphase chromatin. This technique can be used for identification of chromosomal abnormalities and for gene mapping. (from Online Medical Dictionary and NHGRI Glossary)
C17564	Guidelines	Document_Type	Guidelines
C17565	Sequence_Analysis	Techniques	Sequence Analysis|SEQ-AN	The determination of the sequence of component residues in a macromolecule, e.g. amino acids in a protein or nucleotide bases in DNA/RNA or the computational analysis performed to determine the similarities between nonidentical proteins or molecules of DNA or RNA.
C17566	MCC_Gene	Gene_with_Unknown_or_Unclassified_Function	MCC Gene|MCC|Mutated in Colorectal Cancers Gene	Expressed in a variety of tissues, human MCC Gene at 5q21 encodes MCC Protein, a putative tumor suppressor protein with a short region of similarity to a G protein-coupled M3 muscarinic acetylcholine receptor. (from SWISS-PROT, OMIM, and NCI)
C17567	APC_Gene	Signaling_Pathway_Gene	APC Gene|APC|Adenomatosis Polyposis Coli Gene|DP2|DP2.5|DP3|FAP|FPC|GS	The APC gene at 5q21-q22 consists of fifteen exons and is expressed in a variety of tissues from two promoters. Tissue-specific splicing generates transcripts with at least five 5-prime noncoding forms and a brain-specific transcript contains an extra exon. APC protein forms homooligomers and is located in the membrane/cytoskeleton or in the nucleus. APC/ASEF complexes regulates the actin cytoskeleton. Cytoplasmic APC is often found in mesenchymal and epithelial subapical regions and may regulate cell adhesion or contact inhibition by maintaining beta-catenin steady state levels. APC/beta-catenin binds to DLG, which may regulate cell cycle progression and neuronal function. Accumulation of beta-catenin increases transcription of TCF4 target genes, such as MYC. Mutation of APC is associated with familial adenomatous polyposis, Gardner's syndrome, HDD/FIF, Turcot syndrome, and sporadic colorectal cancer. (from SWISS-PROT, OMIM, and NCI)
C17568	Protein_Folding	Biophysical_Process	Protein Folding	The change in structure whereby a polypeptide assumes its functional shape or conformation. This is a process that occurs during either protein biosynthesis or protein reconstitution. Polypeptide chains assume their correct three-dimensional conformation through discrete intermediate (primary, secondary, and tertiary) structures prior to the development final quaternary structure.
C17569	Aryldialkylphosphatase	Hydrolase	Aryldialkylphosphatase|Aryltriphosphatase|Aryltriphosphate dialkylphosphohydrolase|Esterase B1|Esterase E4|OPA anhydrase|OPH|Paraoxon esterase|Pirimiphos-methyloxon esterase	Acts on organophosphorus compounds (such as paraoxon) including esters of phosphonic and phosphinic acids.  Inhibited by chelating agents; requires divalent cations for activity.  Previously regarded as identical with EC 3.1.1.2 Arylesterase [EC 3.1.8.1 created 1989] (from IUBMB Enzyme Nomenclature).
C17570	Nucleophosmin	Nuclear_Matrix_Protein	Nucleophosmin|B23 Nuclear Matrix Protein|NPM1|Nucleolar Phosphoprotein B23|Numatrin	A human nuclear matrix protein with demonstrated immunohistochemical staining differences between benign and malignant prostate tissue.
C17571	Matrix_Metalloproteinase-3	Matrix_Metalloproteinase	Matrix Metalloproteinase 3|MMP3|Progelatinase|Proteoglycanase|Stromelysin 1|Transin-1	This protein is an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. (from LocusLink)
C17572	Focal_Adhesion_Kinase-1	FAK_Family_Tyrosine_Kinase	Focal Adhesion Kinase 1|FAK|FAK1|Focal Adhesion Kinase|PTK2|PTK2 Protein Tyrosine Kinase 2|p125FAK	Focal adhesion kinase (PTK2) lacks significant homology with other kinases and concentrates in focal adhesions between cells growing in extracellular matrix constituents. PTK2 contains phosphotyrosine in growing cells, or after treatment with cholecystokinin, bombesin, vasopressin, or endothelin, but little in detached cells. Activation of PTK2 may be important in signal transduction pathways triggered by neural peptides or by cell interactions with the extracellular matrix. PTK2 is a major substrate for pp60v-src. A CRK-associated tyrosine kinase substrate, p130-CAS, is a PTK2-interacting protein. This interaction requires the proline-rich region of PTK2 and the SH3 domain of p130-CAS. The interaction may also be a key element in integrin-mediated signal transduction and may represent a direct molecular link between the SRC and CRK oncoproteins. FAK may be an endogenous substrate for insulin receptor associated tyrosine kinase. (from OMIM and NCI)
C17573	Cytochrome-P450-3A4	Cytochrome-P450	Cytochrome P450 3A4|CYP3A4|Cytochrome P450 Nifedipine Oxidase|Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 3|Cytochrome P450, Subfamily IIIA (Niphedipine Oxidase), Polypeptide 4|Cytochrome P450, Subfamily IIIA, Polypeptide 4|Cytochrome P450PCN1|EC 1.14.14.1|Glucocorticoid-Inducible P450|Nifedipine Oxidase|P450, FAMILY III|P450-3A4|P450-III, Steroid Inducible|P450-III, Steroid-Inducible|Quinine 3-Monooxygenase|Steroid-Inducible P450- III	Induced primarily in liver by glucocorticoids, drugs, pesticides, and carcinogens and encoded by human CYP3A4 Gene (Cytochrome P450 IIIA Subfamily), Cytochrome P450 3A4 is a 502-amino acid 57.3-kD membrane-bound ER heme-thiolate monooxygenase. CYP3A4 is involved in an NADPH-dependent electron transport pathway and phase I oxidative metabolism of carcinogens, steroids, fatty acids, and xenobiotics, as well as bioactivation of aflatoxin B(1) to a genotoxic derivative. Activity seems a key predictor of drug responsiveness and toxicity. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C17574	p59-FYN	SRC_Family_Tyrosine_Kinase	p59-FYN|FYN|FYN Protein	p59-FYN contains an SH2 and an SH3 domain, is a SRC/YES-related tyrosine kinase expressed in various cell types, and is implicated in the control of cell growth.  FYN is quickly activated after mIg cross-linking on B-cells or TCR cross-linking on T-cells.  FYN associates, through its SH3 domain, with PI3-kinase p85 subunit and interacts with FYN-binding protein FYB.  Upon induction of the murine 1C11 clone by PrPc-dependent signal transduction, epithelial cells develop a neural-like morphology and differentiate into either serotonergic or noradrenergic cells, depending on stimulus.  Phosphorylation of FYN is linked to ligation of PrPc, the cellular, nonpathogenic isoform of prion protein, a ubiquitous glycoprotein expressed strongly in neurons.  The coupling of PrPc to FYN is dependent upon caveolin-1. (from OMIM 137025, Swiss-Prot P06241, and NCI)
C17575	Matrix_Metalloproteinase-9	Matrix_Metalloproteinase	Matrix Metalloproteinase-9|Gelatinase B|MMP-9 Protein|MMP9|Macrophage Gelatinase|Type V Collagenase	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This enzyme degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. (from LocusLink)
C17576	Papillomavirus_Type_6_Protein-E7	Papillomavirus_Transforming_Protein-E7	Oncogene Protein, E7 Human Papillomavirus Type 6
C17577	Autocrine_Mobility_Factor_Receptor	Cytokine_Receptor	Autocrine Mobility Factor Receptor|AMF Receptor|AMF-R|AMFR|AMFR Protein|GP78|RNF45	Secreted by tumor cells, autocrine motility factor stimulates tumor motility.  Its glycoprotein receptor, Autocrine Mobility Factor Receptor, has some homology to p53.  In normal fibroblasts, receptor expression appears to be regulated by cell-cell contact.  The level of expression is associated with the pathologic stage and grade of tumor penetration.  Positive AMFR expression on tumor cells correlates with poor prognosis in bladder cancer.  (from OMIM 603243 and NCI)
C17578	TATA_Box_Binding_Protein	Basal_Transcription_Factor|Sequence-Specific_DNA_Binding_Protein	TATA Box Binding Protein|GTF2D|GTF2D1|SCA17|TATA Box-Binding Protein|TATA Sequence-Binding Protein|TATA-Binding Protein|TATA-Box Factor|TBP	The TATA Binding Protein (TBP) is a DNA-binding component of the TFIID basal transcription factor of the class II genes (transcribed by RNA polymerase II), the TFIIIB class III transcription factor, and the TIF-1B (SL1) class I factor.  Its name is derived from the A-T rich DNA motif that it binds to in the class II genes, most commonly TATAAAA.
C17579	RAC-Alpha_Serine-Threonine_Kinase	Protein_Kinase_B	RAC-Alpha Serine/Threonine Kinase|AKT1|C-AKT|PKB|PKB Protein|PRKBA|Protein Kinase B Alpha|RAC|RAC-Alpha Protein Kinase|RAC-PK-Alpha	RAC-Alpha Serine/Threonine Kinase (AKT1) encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. The activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. AKT1 also promotes cell survival and regulates nitric oxide from endothelium, target of the PDGF-activated phosphatidylinositol 3-kinase. (From LocusLink and NCI)
C17580	Protein_Kinase-B_Beta	Protein_Kinase_B	Protein Kinase B Beta|AKT2|AKT2 Kinase|RAC-Beta Protein Kinase|RAC-Beta Serine/Threonine Kinase|RAC-PK-Beta	The AKT2 oncogene encodes RAC-beta protein kinase, belonging to a serine/threonine kinase subfamily containing SH2-like domains.  The AKT2 isoform of PI-dependent protein kinase Akt is enriched in insulin-responsive tissues and may function in the metabolic actions of that hormone.  Glucose homeostasis depends on insulin responsiveness in target tissues.  Insulin induces phosphorylation of scaffolding proteins and activation of PI3-kinase, which activate Akt.  A deficiency of Akt2 impairs the ability of insulin to lower blood glucose and may function in the maintenance of normal glucose homeostasis.  (from OMIM 164731 and NCI)
C17581	Tumor-Associated_Antigen-L6	Transmembrane_Protein	Transmembrane 4 Superfamily Member 1|L6|L6 Antigen|L6 Cell Surface Antigen|TM4SF1|TM4SF1t|Tumor-Associated Antigen L6	The protein is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. (from LocusLink)
C17582	bZIP_Protein	DNA_Binding_Protein	bZIP Protein	Bipartite DNA binding protein containing a basic region that directly interacts with DNA, and a leucine zipper that mediates dimerization through contacts with a protein partner.
C17583	I-Kappa-B_Protein	Signaling_Protein	I Kappa B|IKB|NF-Kappa B Inhibitor|NFKB Inhibitor|NFKBI	Interacting with p65 (RELA), widely expressed 36-38kDa unphosphorylated cytoplasmic ANK-repeat human I Kappa B Proteins A/B/E (NFKBI Family) inhibit NF-Kappa-B, trapping it in the cytoplasm. By complexing with NFKB, IKBs regulate NFKB transcription in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. Cytokine-activated serine phosphorylation of IKBs by IKBKA/IKBKB disables the NFKB inhibition by dissociation; promotes polyubiquitinated proteasome-dependent IKB degradation; and allows NFKB nuclear translocation, binding at kappa-B DNA motifs, and target gene transcription. (NCI)
C17584	Forkhead_Box_Protein-G1B_Protein	Transcription_Factor	Forkhead Box Protein G1B|BF1 Protein|Brain Factor 1|FKHL1|FKHL1 Protein|Forkhead (Drosophila)-like 1 Protein|Forkhead Protein G1B|HFK1|Transcription Factor BF1	Forkhead Box Protein G1B acts as transcriptional repressor and belongs to the large FKH/HNF3 family of transcription factors, that includes the Drosophila homeotic FKH and mammalian HNF3 and BF1 proteins.  Family members share a unique DNA-binding FKH box.  FOXG1B expression is restricted to telencephalic neurons, with strong expression in the dentate gyrus and hippocampus.  (from OMIM 164874 and NCI)
C17585	Erythrocyte-Brain_Glucose_Transporter_Type-1	Transport_Protein	Glucose Transporter Type 1, Erythrocyte/Brain|GLUT1 Protein|HepG2 Glucose Transporter|SLC2A1|Solute Carrier Family 2, Facilitated Glucose Transporter, Member 1	GLUT1 is an integral membrane glycoprotein involved in transporting glucose into most cells.  It is consistently overexpressed in endometrial adenocarcinomas and atypical hyperplasia, but not in typical hyperplasia.  Immunostaining for GLUT1 may distinguish benign endometrial hyperplasia from potentially malignant hyperplasia.  GLUT1 immunoreactivity in endometrial hyperplasia appears to be a useful indicator of high risk for development of endometrial carcinoma. (from Medscape)
C17586	Cyclin-Dependent_Kinase_Inhibitor-1C	Cyclin-Dependent_Kinase_Inhibitor	Cyclin-Dependent Kinase Inhibitor 1C|Beckwith-Wiedemann Syndrome Protein|CDKN1C|CDKN1C Protein|Cyclin-Dependent Kinase Inhibitor p57|KIP2 Protein|p57-KIP2 Protein	A negative regulator of cell proliferation, KIP2 is a tight-binding inhibitor of the G1 Cyclin E-CDK2, Cyclin D2-CDK4, and Cyclin A-CDK2 complexes, and also inhibits mitotic Cyclin B-CDC2. The N-terminal CDK inhibitory domain is similar to p21(CIP1). (from SWISS-PROT P49918, OMIM 600856, and NCI)
C17587	Insulin-Like_Growth_Factor-Binding_Protein-6	Insulin-Like_Growth_Factor-Binding_Protein	Insulin-Like Growth Factor-Binding Protein 6|IGF Binding Protein 6|IGFBP-6|IGFBP6|Insulin-Like Growth Factor Binding Protein 6	IGFBP6 contains a thyroglobulin type-I domain, belongs to the IGFBP family, and may function as an autocrine growth inhibitor. IGFBPs display strong sequence homologies. IGFBPs contain three distinct domains. N-terminal domain 1 and C-terminal domain 3 contain invariant cysteine residues and are the IGF binding domains. Domain 2 generally lacks sequence identity among the IGFBPs. Domain 3 is homologous to the thyroglobulin type I repeat.  IGF-I and IGF-II circulate in plasma tightly bound to IGFBPs. IGFs, IGFRs, and IGFBPs regulate cell proliferation and apoptosis and the primary effect of IGFBPs appears to be modulation of IGF activity and control of IGF-mediated cell growth and metabolism. Secreted IGF-binding proteins prolong the half-life of IGFs (somatomedins) and either inhibit or stimulate the growth promoting effects of IGFs by altering the interaction of IGFs with cell surface receptors. (from OMIM 146735, SWISS-PROT P24592 and NCI)
C17588	SPT3_Protein	Protein_Complex_Subunit|Transcription_Repressor_Corepressor	SPT3 Protein|SUPT3H|SUPT3H Gene Product|Suppressor of TY 3 Homolog	A subunit of the P/CAF transcription complex, SPT3 is similar to yeast SPT3. (from OMIM 602947 and NCI)
C17589	Mitogen-Activated_Protein_Kinase-1	Mitogen-Activated_Protein_Kinase	Mitogen-Activated Protein Kinase 1|Extracellular Signal-Regulated Kinase 2|MAP Kinase 1|MAPK1|PRKM1|p42MAPK	Encoded by Human MAPK1 Gene (MAPK Family) as alternative p40 and p41 isoforms, Mitogen-Activated Protein Kinase 1 is a proline-directed Ser/Thr kinase activated in response to extracellular stimuli and widely involved in signal transduction as an integration point for multiple biochemical signals and as part of complex protein kinase cascades involved in a cell proliferation, differentiation, transcription regulation, and development. Autophosphorylated and phosphorylated/activated by upstream kinases on threonine and tyrosine residues, MAPK1 forms dimers with phosphorylated and unphosphorylated ERK partners, translocates to the nucleus and phosphorylates target transcription factors. MAPK1 phosphorylates MAP2, MBP, and ELK-1. (NCI)
C17590	Fibroblast_Growth_Factor_Receptor-1	Fibroblast_Growth_Factor_Receptor_Family	Fibroblast Growth Factor Receptor 1|FGFR1	Acidic fibroblast growth factor stimulates tyrosine kinase activity of FGFR1, the receptor for acidic FGF.  The receptor is a transmembrane protein that contains three extracellular Ig-like domains, an unusual acidic region, and an intracellular tyrosine kinase domain.  (from OMIM 136350 and NCI)
C17591	GRB2_Protein	Retired_Concepts	GRB2 Protein|GRB2	An adaptor protein which bridges cell surface tyrosine kinase receptors with downstream signal transmitters such as ras p21. (from IRB Summaries)
C17592	Matrix_Metalloproteinase-2	Matrix_Metalloproteinase	Matrix Metalloproteinase 2|72kD type IV Collagenase|Gelatinase A|Gelatinase Neutrophil|MMP2|PEX	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This enzyme degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. (from LocusLink)
C17593	Zuotin	Yeast_Protein	Zuotin	Identified in yeast, Zuotin, containing one J domain, is a Z-DNA-binding protein and ribosomal chaperone that may be involved in chromosome organization.  (from OMIM 605502, SWISS-PROT P32527, and NCI)
C17594	Matrix_Metalloproteinase-11	Matrix_Metalloproteinase	Matrix Metalloproteinase 11|MMP11|ST-3 Protein|ST3 Matrix Metalloproteinase|Stromelysin 3	A protease believed to play a role in tumor invasion and metastasis.  May contribute to tissue-remodeling processes associated with carcinoma progression.
C17595	HRX_Protein	DNA_Binding_Protein	HRX Protein|ALL-1 Protein|MLL|MLL Protein	The MLL (HRX) nuclear protein contains N-terminal 'AT-hook' motifs and extensive homology to the Drosophila trithorax protein, particularly in the cysteine-rich zinc finger-like domains.  HRX may bind AT-rich DNA and is likely to be a transcriptional regulator.  (from OMIM 159555 and NCI)
C17596	Zeta-Chain_Associated_Protein_Kinase	syk_Family_Tyrosine_Kinase	Zeta-Chain Associated Protein Kinase|E.C. 2.7.1.112|Protein Tyrosine Kinase Zap70|Syk-Related Tyrosine Kinase|ZAP-70|Zeta-Chain (TCR) Associated Protein Kinase|Zeta-Chain Associated Protein Kinase, 70kd	A protein tyrosine kinase in the syk family of kinases, with signaling functions in the T-cell receptor (TCR) signal transduction pathway.  Associates with the zeta and CD3 chains of the receptor.
C17597	Adhesion	Physical_Phenomena_or_Properties	Adhesion	The property of remaining in close proximity, as that resulting from the physical attraction of molecules to a substance or the molecular attraction existing between the surfaces of contacting bodies. (On-line Medical Dictionary)
C17598	Prosthesis	Medical_Device	Prosthesis|Prostheses|prosthesis	(pros-THEE-sis) An artificial replacement of a part of the body.
C17599	Immunologist	Miscellaneous_Occupations	Immunologist	A specialist in the science of immunology.
C17600	Adult	Age_Group	Adult|Adult Human (21+)|Human, Adult	A human who has reached reproductive age.
C17601	Bacterial_Genetics	Microbial_Genetics	Bacterial Genetics	Subdiscipline of genetics with a focus on bacteria.
C17602	Critical_Care_Nursing	Clinical_Nursing	Critical Care Nursing	Critical care nursing is that specialty within nursing that deals specifically with human responses to life-threatening problems. A critical care nurse is a licensed professional nurse who is responsible for ensuring that all critically ill patients and their families receive optimal care. (AACN)
C17603	Environmental_Toxicology	Toxicology	Environmental Toxicology
C17604	Food_Preparation	Food_Science_and_Technology	Food Preparation	The process of taking raw food and producing a finished meal.  Investigations into the link between food preparation methods and human disease
C17605	Food_Science_and_Technology	Technology	Food Science and Technology	The application of knowledge to the food industry.
C17606	Image_Processing	Imaging_Technology	Image Processing|Image Analysis	The use of data processing systems to analyze, enhance, interpret or display digital images.
C17607	Nucleocapsid_Protein	Capsid_Protein	Nucleocapsid Protein	The gene product limited to virus, and was found in either the nucleocapsid structure or the viral core.
C17608	Plant_Genetics	Genetics	Plant Genetics	this term is to be used for the macro-algae, Embryophytes (mosses), and Tracheophytes (angiosperms, gymnosperms, etc.)
C17609	Tumor_Progression	Cancer_Progression	Tumor Progression	The molecular steps that continually advance a cancer or cancer cell into a more malignant and aggressive phenotype. The process of tumor progression is thought to be driven by clonal evolution. The initiating event is a mutation that gives a cell the ability to divide when it shouldn't.  As a result a small group of related cells, called a clone because they are identical to each other, grows. Clonal evolution occurs like a tree with mutations causing many clones to branch off continuously.
C17610	Blood_Sample	Specimen	Blood Sample
C17611	Bronchoscope	Endoscope	Bronchoscope|bronchoscope	(BRON-ko-skope) A thin, lighted tube used to examine the inside of the trachea and bronchi, the air passages that lead to the lungs.
C17612	Central_Venous_Access_Catheter	Catheter	Central Venous Access Catheter|central venous access catheter	A tube surgically placed into a blood vessel for the purpose of giving intravenous fluid and drugs. It also can be used to obtain blood samples. This device avoids the need for separate needle insertions for each infusion or blood test. Examples of these devices include Hickman catheters, which require clamps to make sure the valve is closed, and Groshong catheters, which have a valve that opens as fluid is withdrawn or infused and remains closed when not in use.
C17613	Colonoscope	Endoscope	Colonoscope|colonoscope	(ko-LAHN-o-skope) A thin, lighted tube used to examine the inside of the colon.
C17614	Colposcope	Endoscope	Colposcope|colposcope	A lighted magnifying instrument used for examination of the vagina and cervix.
C17615	Curette	Medical_Device	Curette|curette	(kyoo-RET) A spoon-shaped instrument with a sharp edge.
C17616	Cystoscope	Endoscope	Cystoscope|cystoscope	(SIS-toe-skope) A thin, lighted instrument used to look inside the bladder and remove tissue samples or small tumors.
C17617	Dilator	Medical_Device	Dilator|dilator	(DYE-lay-tor) A device used to stretch or enlarge an opening.
C17618	Laryngoscope	Endoscope	Laryngoscope|laryngoscope	(la-RING-guh-skope) A thin, lighted tube used to examine the larynx (voice box).
C17619	Fluoroscope	Imaging_Device	Fluoroscope|fluoroscope	(FLOOR-o-skope) An x-ray machine that makes it possible to see internal organs in motion.
C17620	Gastroscope	Endoscope	Gastroscope|gastroscope	(GAS-tro-skope) A thin, lighted tube used to view the inside of the stomach.
C17621	Humidifier	Medical_Device	Humidifier|humidifier	(hyoo-MID-ih-fye-er) A machine that puts moisture in the air.
C17622	Ophthalmoscope	Optical_Instrument	Ophthalmoscope|ophthalmoscope	(off-THAL-mo-skope) A lighted instrument used to examine the inside of the eye, including the retina and the optic nerve.
C17623	Patient_Monitoring_System	Medical_Device	Patient Monitoring System
C17624	Picture_Archiving_and_Communication_System	Information_Sciences	Picture Archiving and Communication System|Medical Imaging, Picture Archiving and Communication Systems
C17625	Pump	Medical_Device	Pump|pump	A device that is used to deliver a precise amount of drug at a specific rate.
C17626	Sigmoidoscope	Endoscope	Sigmoidoscope|sigmoidoscope	(sig-MOY-da-skope) A thin, lighted tube used to view the inside of the colon.
C17627	Swab	Medical_Device	Swab	A tuft of material on the end of a stick for applying solutions and suspensions
C17628	Tracheostomy_Button	Medical_Device	Tracheostomy Button|tracheostomy button	(TRAY-kee-AHS-toe-mee) A 0.5-inch- to 1.5-inch-long plastic tube placed in a surgically created opening (tracheostomy) in the windpipe to keep it open.
C17629	Tracheostomy_Tube	Medical_Device	Tracheostomy Tube|trach tube|tracheostomy tube	(TRAY-kee-AHS-tuh-mee toob) A 2-inch- to 3-inch-long curved metal or plastic tube placed in a surgically created opening (tracheostomy) in the windpipe to keep it open.
C17630	Subcutaneous_Port	Catheter	Subcutaneous Port|subcutaneous port	A tube surgically placed into a blood vessel and attached to a disk placed under the skin. It is used for the administration of intravenous fluids and drugs; it can also be used to obtain blood samples.
C17631	Digital_Rectal_Examination	Physical_Examination	Digital Rectal Examination|DRE|digital rectal examination	DRE. An examination in which a doctor inserts a lubricated, gloved finger into the rectum to feel for abnormalities.
C17632	DNA_Analysis	Molecular_Biology_Techniques	DNA Analysis	Any DNA based laboratory tests.
C17633	Restriction_Fragment_Length_Polymorphism_Analysis	Polymorphism_Analysis|Restriction_Enzyme_Analysis	Restriction Fragment Length Polymorphism Analysis	Use of restriction fragment polymorphism for detection of point mutations or other chromosomal changes.
C17634	PSA_Assay	Test|Test_Generic	PSA Assay|Prostate Specific Antigen Assay	Serum measurement of prostate specific antigen.
C17635	Tumor_Necrosis_Factor_Assay	Bioassay_in_vitro	Tumor Necrosis Factor Assay|TNF Assay	An immunoassay to detect Tumor Necrosis Factor (TNF), which is a potent lymphoid factor, and exerts cytotoxic effects on a wide range of tumor cells and other target cells. Utilizes monoclonal antibody to TNF immobilized on microtitre plate.(NCI2005)
C17636	Antigen_Proliferation_Assay	Immunologic_Techniques	Antigen Proliferation Assay	An in vitro test of T-cell function
C17637	Capillary_Electrophoresis	Gel_Electrophoresis	Capillary Electrophoresis|Fractionation, Capillary Electrophoresis	An electrophoresis technique, in which a sample is introduced into a capillary tube and the components are separated by the application of high voltage. Due to the large surface to volume ratio, cooling is more efficient, allowing use of higher voltages.  As a result, separation occurs more quickly and sensitivity is increased. The technique allows for separation of proteins, nucleic acids, and carbohydrates.
C17638	Immunoblot_Analysis	Immunologic_Techniques	Immunoblot Analysis	A technique for analyzing or identifying proteins immobilized on a filter by complementary reaction with specific antibodies. (NCI2005)
C17639	Upper_GI_Series	Radiography	Upper Gastrointestinal Series|Barium-Swallow X-ray|UPGISER|Upper GI|Upper Gastrointestinal Tract Radiography|upper GI series	A series of x-rays of the upper digestive (gastrointestinal, or GI) system that are taken after a person drinks a barium solution, which outlines the digestive organs on the x-rays.
C17640	Esophagram	Medical_Image	Esophagram|Contrast Esophagram|Esophagogram|esophagram	(eh-SOF-a-gram) A series of x-rays of the esophagus. The x-ray pictures are taken after the person drinks a solution that contains barium. The barium coats and outlines the esophagus on the x-ray. Also called a barium swallow.
C17641	Percutaneous_Transhepatic_Cholangiography	Diagnostic_Radiology	Percutaneous Transhepatic Cholangiography|PTC|percutaneous transhepatic cholangiography	(per-kyoo-TAY-nee-us trans-heh-PAT-ik ko-LAN-jee-AH-gra-fee) PTC.  A procedure to x-ray the hepatic and common bile ducts. A contrasting agent is injected into the liver or bile duct, and the ducts are then x-rayed to find the point of obstruction.
C17642	Nephrotomogram	Medical_Image	Nephrotomogram|nephrotomogram	(nef-ro-TOE-mo-gram) A series of x-rays of the kidneys. The x-rays are taken from different angles and show the kidneys clearly, without the shadows of the organs around them.
C17643	Intravenous_Pyelogram	Medical_Image	Intravenous Pyelogram|intravenous pyelogram	(in-tra-VEE-nus PYE-el-o-gram) IVP. A series of x-rays of the kidneys, ureters, and bladder. The x-rays are taken after a dye is injected into a blood vessel. The dye is concentrated in the urine, which outlines the kidneys, ureters, and bladder on the x-rays.
C17644	Transvaginal_Ultrasound	Ultrasound_Imaging	Transvaginal Ultrasound|TVS|transvaginal ultrasound	A procedure used to examine the vagina, uterus, fallopian tubes, and bladder. An instrument is inserted into the vagina, and sound waves bounce off organs inside the pelvic area. These sound waves create echoes, which a computer uses to create a picture called a sonogram.
C17645	Radionuclide_Scanning	Imaging_Technique	Radionuclide Scanning|radionuclide scanning	A radionuclide scan is an imaging technique that uses a small dose of a radioactive chemical (isotope) called a tracer that can detect sites of cancer growth, trauma, infection or degenerative disorders. The tracer, which is either injected into a vein or swallowed, travels through the bloodstream to the target organ, and emits gamma rays, which are detected by a gamma camera and analyzed by a computer to form an image of the target organ. (NCI2005)
C17646	Bone_Scan	Scanning_Procedure_or_Technique	Bone Scan|Scan, Bone|bone scan	A technique to create images of bones on a computer screen or on film. A small amount of radioactive material is injected into a blood vessel and travels through the bloodstream; it collects in the bones and is detected by a scanner.
C17647	Liver_Scan	Scan	Liver Scan|liver scan	An image of the liver created on a computer screen or on film. A radioactive substance is injected into a blood vessel and travels through the bloodstream. It collects in the liver, especially in abnormal areas, and can be detected by the scanner.
C17648	Multiple	General_Modifier	Multiple|MULT	Having, relating to, or consisting of more than one individual, element, part, or other component; manifold. (dictionary.com)
C17649	Other	General_Modifier	Other|Other or Miscellaneous	Different than the one(s) previously specified or mentioned.
C17650	Physiologic	General_Modifier	Physiologic|physiologic	Having to do with the functions of the body. When used in the phrase "physiologic age," it refers to an age assigned by general health, as opposed to calendar age.
C17651	Waist-Hip_Ratio	Personal_Attribute	Waist-Hip Ratio	ratio of the abdominal circumference at the navel to maximum hip and buttocks circumference; looks at the proportion of fat stored on your body around your waist and hip; carrying extra weight around the stomach is riskier for your health than carrying extra weight around the hips or thighs.
C17652	Gerontology	Medicine	Gerontology
C17653	British_Virgin_Islands	Country	British Virgin Islands|092|VG|VGB|VI	Islands between the Caribbean Sea and the North Atlantic Ocean, east of Puerto Rico. (CIA World Factbook 2002)
C17654	The_Former_Yugoslav_Republic_of_Macedonia	Country	Republic of Macedonia|807|MK|MKD|Macedonia|Macedonia (Republic)|Macedonia, Former Yugoslav Republic of|The Former Yugoslav Republic of Macedonia	A country in Southeastern Europe, north of Greece. (CIA World Factbook 2002)
C17655	Reproductive_History	Personal_Medical_History	Reproductive History|Reproductive Factors|Reproductive Issues	An account of all reproductive events and problems a person has experienced. An important aggregate factor in epidemiological studies of women's health.  The concept usually includes the number and timing of pregnancies and their outcomes, the incidence of breast feeding, and may include age of menarche and menopause, regularity of menstruation, fertility, gynecological or obstetric problems, or contraceptive usage. (from On-line Medical Dictionary)
C17656	Clonal_Regression	Immune_Function	Clonal Regression
C17657	Molecular_Epidemiology	Epidemiology	Molecular Epidemiology|Epidemiology Molecular|Epidemiology, Molecular	The application of molecular biology techniques in answering epidemiological questions.
C17658	Long_Term_Survivor	Survivor	Long Term Survivor|Long-Term Survivors	Patients who have survived several years
C17659	Survivor	Population_Group	Survivor	Survivor; one who lives through affliction.
C17660	Receptor_Tyrosine_Kinase	Cell_Surface_Receptor	Receptor Tyrosine Kinase|RTK|Receptor Protein-Tyrosine Kinase|Receptor-Tyrosine Kinase|Transmembrane Receptor Protein Tyrosine Kinase|Tyrosine Kinase Growth Factor Receptor	A catalytic PROTEIN-TYROSINE KINASE domain found on the cytoplasmic beta-portion of receptors. Many growth and differentiation factor receptors contain this domain. It is critical for the signal transduction pathways required for mitogenesis, transformation, and cell differentiation. (Neuron 1992;9:383) EC 2.7.1.-.
C17661	Reporter_Gene	Gene	Reporter Gene|Genes, Reporter	A gene which produces an easily assayed phenotype.  Often used for expression studies of heterologous promoters.
C17662	Antigen_Processing	Biochemical_Process	Antigen Processing	The process by which foreign molecules are taken up by antigen presenting cells, proteolytically cleaved, and displayed on the cell surface in complex with MHC molecules.
C17663	Antigen_Presentation	Biochemical_Process	Antigen Presentation	The event of providing fragments of foreign proteins, including viruses and bacteria, to the helper T cells. The presentation occurs through the display of the fragments of foreign proteins on the surface of the antigen-presenting cells (APC). (HIV Glossary; http://aidsinfo.nih.gov)
C17664	Growth_Factor_Receptor	Cell_Surface_Receptor	Growth Factor Receptor|Growth Factor, Receptor|Proto-Oncogene, Growth Factor Receptor	A class of cell surface proteins that bind to extracellular polypeptide molecules triggering intracellular signaling pathways that activate various cellular responses such as cell proliferation and/or differentiation. (NCI)
C17665	Neural_Peptide_Receptor	Cell_Surface_Receptor	Neural Peptide Receptor	A neural peptide receptor is a protein on the cell surface that specifically binds a neural ligand. This receptor binds ligands such as hormones, antigens, drugs, or neurotransmitters. Binding activity mediates signal transduction that affects the nervous system and influences cell behavior.
C17666	Germline_Mutation	Mutation	Germline Mutation|Hereditary Mutation|germline mutation|hereditary mutation	A gene change in the body's reproductive cells (egg or sperm) that becomes incorporated into the DNA of every cell in the body of offspring; germline mutations are passed on from parents to offspring.
C17667	Cytokine_Receptor	Cell_Surface_Receptor	Cytokine Receptor
C17668	Czech_Republic	Country	Czech Republic|203|CZ|CZE|EZ	A country in Central Europe, southeast of Germany. (CIA World Factbook 2002)
C17669	Slovakia	Country	Slovakia|703|LO|SK|SVK	A country in Central Europe, south of Poland. (CIA World Factbook 2002)
C17670	Cytoplasmic_Receptor	Receptor	Cytoplasmic Receptor|Receptor, Cytoplasmic	Cytoplasmic Receptors are selective binding proteins that mediate the physiologic effects of specific bound regulatory molecules, such as hormones that cause a conformational and functional change in the receptor molecule. Interaction of the ligand-bound receptor with target molecules is altered, which leads to changes in cellular physiology through modification of the activity of one or more signal transduction pathways. Steroid receptors are cytoplasmic carriers that translocate to the nucleus upon ligand binding and regulate the expression of specific target genes.
C17671	Nuclear_Receptor	Receptor	Nuclear Receptor|Receptor, Nuclear	Proteins that regulate transcription via interaction with chromatin and basal transcription machinery at the promoter regions of genes. Nuclear receptors are ligand-dependent transcription factors including steroids, retinoids, vitamin D, unliganded thyroid hormone, and orphan receptors (unknown ligands). Coregulators (coactivators or corepressors) are important in mediating these interactions and thereby modulate positive or negative receptor activity.
C17672	X-Ray_Crystallography	Crystallography	X-Ray Crystallography|Crystallography, X-Ray Diffraction|Crystallography, X-Ray/Neutron|Single Crystal Diffraction	X-ray crystallography is a technique in crystallography in which the pattern produced by the diffraction of x-rays through the closely spaced lattice of atoms in a crystal is recorded and then analyzed to reveal the nature of that lattice. (from Wikipedia)
C17673	Cytochrome-P450-1A2	Cytochrome-P450	Cytochrome P450, Family 1, Subfamily A, Polypeptide 2|Aryl Hydrocarbon Hydroxylase|CYP1A2|Cytochrome P-450, Aromatic Compound-Inducible|Cytochrome P450 1A2|Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 2|Dioxin-Inducible P3-450|EC 1.14.14.1|Flavoprotein-Linked Monooxygenase|Microsomal Monooxygenase|P(3)450|P450 4|P450 Form 4|P450 orm 4|P450-P3|Xenobiotic Monooxygenase	A polycyclic aromatic hydrocarbon-inducible cytochrome which is of significant clinical interest due to the large number of drug interactions associated with induction and inhibition of theophylline. Caffeine is considered to be a model substrate for this enzyme. It also metabolizes theophylline and antipyrene. Environmental factors including cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole produce increases in CYP1A2 activity. (Ann Pharmacother 1995;29:619-24) EC 1.-.
C17674	Human_Papillomavirus_Type_18_Protein_E7	Papillomavirus_Transforming_Protein-E7	Human Papillomavirus Type 18 E7 Protein
C17675	Proliferation-Related-Ki-67_Antigen	Cell_Cycle_Protein	Proliferation-Related Ki-67 Antigen|Antigen Identified by Monoclonal Antibody Ki-67|Antigen KI-67|KIA|Ki-67 Antigen|MIB-1|MKI67|MKI67 Protein	Antigen Identified by Monoclonal Antibody Ki-67, encoded by the MKI67 gene, is a nuclear antigen expressed in proliferating cells but not in quiescent cells, and required for maintaining cell proliferation. Expression of this antigen occurs preferentially during late G1, S, G2, and M phases of the cell cycle, while in cells in G0 phase the antigen cannot be detected. Consequently, the monoclonal antibody Ki-67 is used in tumor pathology to detect proliferating cells in neoplastic diseases. This antigen is located in the nucleus, predominantly localized in the G1 phase in the perinucleolar region. In the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes. This antigen contains 1 FHA domain. Two alternative splicing forms exist, Long and Short. (from Swiss-Prot)
C17677	TAF-II-250_Protein	Basal_Transcription_Factor	TAF(II)250|CCG1 Protein|CCGS|Cell Cycle Gene 1 Protein|P250|RNA Polymerase IIA 250kD|TAF1|TAF1 RNA Polymerase II TATA Box Binding Protein|TAF1 RNA Polymerase II TATA Box Binding Protein-Associated Factor 250-kD|TAF2A|TAFII250|TATA Box Binding Protein|TATA Box-Binding Protein-Associated Factor 2A|TBP-Associated Factor|TBP-Associated Factor 1|TBP-Associated Factor 250 kDa|TBP-Associated Factor RNA Polymerase II 250-kD|TBP-Associated Factor, Class II, 250 kDa|TF2D|TFIID|Transcription Factor IID|Transcription Factor TFIID p250 Polypeptide|Transcription Initiation Factor TFIID 250 kDa Subunit	A component of the TFIID protein complex. DNA-binding TAFII250 contains one HMG box and two bromodomains that bind multiply acetylated Histone H4. TAFII250, contains serine/threonine kinase domains that autophosphorylate, and transphosphorylate the large subunit of TFIIF. TAFII250 is essential for progression of the G1 cell cycle phase and may link control of transcription to the cell cycle. (from SWISS-PROT P21675, OMIM 313650, and NCI)
C17678	I-Kappa-B-Alpha_Protein	I-Kappa-B_Protein	I Kappa B-Alpha Protein|I Kappa B A|I Kappa B Alpha|I-Kappa-B-Alpha|IKB-Alpha|IKBA|IKappaB|IKappaB-Alpha|IKappaB/MAD-3|Inhibitor of Kappa Light Chain Gene Enhancer in B Cells, Alpha|MAD-3|MAD3|Major Histocompatibility Complex Enhancer-Binding Protein MAD3|NF-Kappa B Inhibitor Alpha|NFKBI|NFKBIA|Nuclear Factor Kappa-B Inhibitor|Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor|Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor, Alpha|Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor Alpha	Encoded by glucocorticoid-inducible human NFKBIA Gene (NFKBI Family), 317-aa 36-kDa cytoplasmic I-Kappa-B-Alpha contains 5 ANK repeats that interact with p65 RELA C-terminal REL homology regions. By complexing with and trapping NFKB in the cytoplasm, unphosphorylated NFKBIA inhibits NFKB target gene transcription in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. NFKBIA tyrosine phosphorylation leads to dissociation from NFKB, disabling inhibition of NFKB DNA-binding. Stimulus-dependent IKBKA/IKBKB serine phosphorylation of NFKBIA results in polyubiquitination and for rapid degradation via the ubiquitin system. (NCI)
C17679	Upstream_Stimulatory_Factor	Protein_or_Riboprotein_Complex	Upstream Stimulatory Factor|USF|Upstream Transcription Factor	The ubiquitous bZIP transcription factor Upstream Stimulatory Factor binds to many viral and cellular promoters.  USF consists of two related polypeptides USF1 and USF2.  USF function may support the host immune response by promoting MHC class I and class II antigen expression.  (from OMIM 191523, 600390 and NCI)
C17680	Cyclin-Dependent_Kinase-4	Cyclin-Dependent_Kinase	Cyclin-Dependent Kinase 4|CDK4|CDK4 Protein|Cell Division Protein Kinase 4|Cyclin Dependent Kinase 4	A serine/threonine protein kinase involved in cell cycle control, Cdk4 may complex with D-type G1 Cyclins and belongs to the CDC2/CDKX subfamily.  CDK4/CDK6 phosphorylates Rb in early G1, displacing histone deacetylase and blocking transcriptional repression.  CDK4 is inhibited by p16 (Cyclin-Dependent Kinase Inhibitor-2). (NCI)
C17681	TIMP-3	Angiogenesis_Inhibitory_Protein|Tissue_Inhibitor_of_Metalloproteinases	TIMP-3|K222 Expressed in Degenerative Retinas|MIG-5 Protein|Metalloproteinase Inhibitor 3|Tissue Inhibitor of Metalloproteinase-3	Encoded by widely expressed, mitogenically induced, and cell cycle regulated human TIMP3 Gene (TIMP Family), 27-kD glycosylated TIMP-3 is an angiogenesis inhibitor containing 12 conserved cysteines, localized in the ECM, and similar to TIMP-1 and TIMP-2. TIMP-3 complexes with and inactivates matrix metalloproteinases, involved in extracellular matrix degradation. TIMP family members may possess selective affinities for matrix metalloproteinases. Likely part of acute response tissue-specific remodeling, TIMP-3 acts on MMP-1, -2, -3, -7, -9, -13, -14 and -15. The N-terminus inhibits MMPs; the C-terminus mediates specific molecular functions. TIMP3 inhibits VEGF-mediated angiogenesis; it blocks VEGF binding to VEGFR2. Gene mutations cause Sorsby fundus dystrophy. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C17682	Multiple_Drug_Resistance-Associated_Protein	ABC_Transporter	ATP-Binding Cassette, Sub-Family C, Member 1|ABCC1|MRP1 Protein|Multiple Drug Resistance-Associated Protein	The MRP1 Protein constitutes a multidrug resistance-associated plasma membrane drug-efflux pump, detectable in lung, testis, and peripheral blood mononuclear cells.  This transporter protein is similar to ABC superfamily of transport systems and is over expressed in a multidrug-resistant SCLC cell line.  (from OMIM 158343 and NCI)
C17683	Core-Binding_Factor	Protein_or_Riboprotein_Complex	Core-Binding Factor|CBF	CBF is an alpha/beta heterodimeric transcription factor involved in the transcriptional regulation of several genes important in hematopoiesis.  The CBFalpha subunit binds directly to the enhancer core DNA sequence on target genes, whereas the beta subunit does not bind the DNA directly but increases the affinity and stabilizes the binding of the alpha subunit to the DNA.
C17684	Activating_Transcription_Factor-2	Transcription_Factor	Activating Transcription Factor 2|ATF2|CRE-BP1|CRE-Binding Protein 1|CREB2|Cyclic AMP Response Element Binding Protein A|HB16|TREB7	ATF proteins have been reported to be able to bind with FOS proteins to form the AP-1 transcription factor (from Nature Cell Biol. 4: E131-E136, 2002 via OMIM)
C17685	ERBB4_Receptor_Protein_Tyrosine_Kinase	ErbB_Receptor_Family_Protein	ERBB4 Receptor Protein Tyrosine Kinase|c-erbB-4|erbB4	ErbB4 heterodimerizes with other type I receptor tyrosine kinases. In the peripheral nervous system, ErbB4 helps regulate glial proliferation and acts as a signaling molecule at the neuromuscular junction. In the mature CNS, ErbB4 is expressed in cerebellar granule cells and in a subset of cells that also express the neurotransmitter: aminobutyric acid. ErbB4 is critical in cardiac development.  It is overexpressed frequently in several common solid tumors, including in breast cancer.
C17686	NF-Kappa-B-p65_Protein	Protein_Complex_Subunit|Transcription_Factor	NF-Kappa B p65|NF-kB p65 Subunit|NF-kappaB|NF-kappaB(p65)|NFKB3|Nuclear Factor Kappa-B Subunit 3|Nuclear Factor NF-Kappa-B p65 Subunit|Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells 3|RELA|Transcription Factor NFKB3|Transcription Factor p65|V-REL Avian Reticuloendotheliosis Viral Oncogene Homolog A	Bound to NFKB1 or NFKB2 to form NFKB and trapped in the cytoplasm by IkB proteins (primarily through p65), p65 belongs to the Rel/Dorsal family. IKB kinases phosphorylate IkB and activate NFKB via destructive ubiquitination. Translocated, activate NFKB transcription factor binds the enhancer Kappa-B 5'-GGRNNYYCC-3' DNA motif, in immune response and acute phase reaction genes. (from SWISS-PROT Q04206, OMIM 164014, and NCI)
C17687	Adenomatous_Polyposis_Coli_Protein	Signaling_Protein	Adenomatous Polyposis Coli Protein|APC|APC Protein	APC protein is expressed in many tissues. The cytoplasmic APC complex may regulate cell adhesion or transmission of contact inhibition signals into cells. APC is associated with beta-Catenin, which binds and activates E-Cadherin that controls formation and maintenance of epithelial adherens junctions. The APC/ASEF/beta-Catenin complex regulates the actin cytoskeleton and cell morphology/migration. Inactivating mutations of APC cause accumulation of beta-Catenin, which binds TCF4 and increases transcription of target genes (e.g., c-MYC) and binds GSK3-beta in the WNT signaling pathway. APC is a nucleocytoplasmic shuttle protein. During mitosis, APC localizes to microtubule ends within kinetochores forming a complex with BUB1 and BUB3 checkpoint proteins. APC mutant cells form mitotic spindles with microtubules that ineffectively connect with kinetochores, leading to chromosomal instability and defective chromosome segregation. (from OMIM and NCI)
C17688	MCL-1_Protein	Apoptosis_Inhibitor	MCL-1 Protein|MCL1|Myeloid Cell Leukemia Sequence 1	Is a 37 kDa protein that expressed in many types of long-lived cells. Mcl-1 protein is found in mitochondrial and other membranes also. Mcl-1 appears to function as a repressor of apoptotic cell death. It interacts with Bax, a protein promoting cell death. Overproduction of Mcl-1 can delay cell death by apoptosis associated with growth factor withdrawal, overexpression of the myc oncogene, or treatment with cytotoxic agents.
C17689	Cortactin	Actin-Binding_Protein	Cortactin|Amplaxin|CTTN|EMS1|EMS1 Protein|Mammary Tumor and Squamous Cell Carcinoma-Associated Protein|SRC Substrate Cortactin|SRC8|p80/85 SRC Substrate	Encoded by human EMS1 Gene, 550-amino acid Cortactin is an actin-binding protein involved in restructuring of the cortical actin cytoskeleton. Similar to murine Cttn, cytoplasmic Cortactin is located in cell-substratum contact areas and contains one SH3 domain that may bind to the cytoskeleton. Cortactin may organize epithelial cell structure; it regulates interactions between adherens junction components and interacts with the cytoskeleton. It may interact with SHANK2 and SHANK3 via its SH2 domain. A substrate for pp60v-SRC, Cortactin tyrosine phosphorylation may regulate cell growth. EGF enhances p85 phosphorylation and causes p80 to p85 conversion. Posttranslational modification of Cortactin coincides with redistribution to cell-matrix contact sites. Cortactin is degraded during apoptosis in a caspase-dependent manner.  (from Swiss-Prot, OMIM, and NCI)
C17690	Hypoxia-Inducible_Factor-1	Protein_or_Riboprotein_Complex	Hypoxia-Inducible Factor-1|HIF-1	Hypoxia-inducible factor-1 (HIF1) is a transcription factor found in mammalian cells cultured under reduced oxygen tension that plays an essential role in cellular and systemic homeostatic responses to hypoxia. HIF1 is a heterodimer composed of a 120-kD HIF1-alpha subunit complexed with a 91- to 94-kD HIF1-beta subunit.
C17691	c-Ros_Tyrosine_Kinase	Receptor_Tyrosine_Kinase	c-Ros Tyrosine Kinase|ROS1|ROS1 Protein|gp280	A type I membrane protein, c-ROS tyrosine kinase is probably a cell growth- or differentiation factor receptor that belongs to the insulin receptor family, sevenless subfamily.  (from Swiss-Prot P08922 and NCI)
C17692	Reticulon-1	Protein_with_Unknown_or_Unclassified_Function	Reticulon 1|NSP|NSP-A|NSP-B|NSP-C|Neuroendocrine-Specific Protein|RTN1	Expressed in neural and neuroendocrine tissues by human RTN1 Gene (Reticulon Family), 3 isoforms (A, B, C) of Reticulon 1, with unique N termini, are localized to ER membranes and contain a reticulon domain and 2 large C-terminal hydrophobic domains. RTN1 may be involved in neuroendocrine secretion or membrane trafficking. RTN1-A is a 776-aa 135-kD Ser/Pro-rich protein that contains multiple potential phosphorylation sites; RTN1-B is 356-aa and RTN1-C is 208-aa. RTN1-A and RTN1-B are phosphorylated and expression of RTN1-C is strongly correlated with neuronal differentiation. (NCI)
C17693	NK-Tumor_Recognition_Protein	Cell_Surface_Receptor	NK-Tumor Recognition Protein|NKTR|NKTR Protein|Natural Killer Triggering Receptor	The cell surface NKTR Protein is involved in the recognition of tumor cells by large granular lymphocytes, a subpopulation of white blood cells that kill tumor cells by an MHC-independent mechanism.  The protein contains a unique amino acid structure and an external cyclophilin-related domain.  (from OMIM 161565 and NCI)
C17694	Cytochrome-P450-2C18	Cytochrome-P450	Cytochrome P450, Family 2, Subfamily C, Polypeptide 18|CYP2C18|CYPIIC18|Cytochrome P450 2C18|Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 17|Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 18|Cytochrome P450, Subfamily IIC, Polypeptide 18|EC 1.14.14.1|Flavoprotein-Linked Monooxygenase|Microsomal Monooxygenase|P450-2C18|P450-6B/29C	Cytochrome P450, Family 2, Subfamily C, Polypeptide 18, encoded by the CYP2C18 gene, is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. (from LocusLink)
C17695	Thrombopoietin_Receptor	Cytokine_Receptor	Thrombopoietin Receptor|CD110|CD110 Antigen|MPL|TPOR|c-MPL Protein	MPL encodes the Thrombopoietin Receptor, a member of the cytokine receptor superfamily.  The mechanism by which TPO activates the TPOR appears similar to that of other hematopoietic cytokines that bind and induce receptor homodimerization.  TPO regulates the production of multipotent hematopoietic progenitor cells and platelets.  Lymphoid progenitors express IL7R and not MPL, whereas myeloid progenitors express MPL and not IL7R.  The receptor for thrombopoietin may also represent a regulatory molecule specific for TPOR-dependent immune responses.  TPOR contains two fibronectin type III-like domains and is a type I membrane protein.  Two isoforms, MPL-K and MPL-P, are produced by alternative splicing and are co-expressed.  (from OMIM 159530, SWISS-PROT P40238, and NCI)
C17696	RAB8_Protein	RAS_Superfamily_Protein	RAB8 Protein|MEL|MEL Gene Product|RAS-Related Protein RAB-8	RAB8 protein (MEL) contains the four GTP/GDP-binding sites present in all RAS proteins.  The putative effector-binding site of MEL is similar to that of RAB/YPT proteins.  However, MEL contains a C-terminal CAAX motif characteristic of many RAS superfamily members but which is not found in YPT1 and the majority of RAB proteins.  Members of the RAS superfamily are small GTP/GDP-binding proteins.  RAB/YPT family proteins may play a role in transport of proteins from the endoplasmic reticulum to the Golgi and the plasma membrane.  (from OMIM 165040 and NCI)
C17697	B_Lymphoid_Tyrosine_Kinase	SRC_Family_Tyrosine_Kinase	B Lymphoid Tyrosine Kinase|B Lymphocyte Kinase|BLK Nonreceptor Tyrosine Kinase|Tyrosine-Protein Kinase BLK|p55-BLK|p55-BLK Kinase	A protein tyrosine kinase activated within seconds after crosslinking the mIg complex on B cells.
C17698	BCL-XL_Protein	Apoptosis_Inhibitor	BCL-XL Protein|BCL-X|BCL-X Long Protein|BCL-X Protein|BCL2-Like 1, Long Isoform|BCL2-Related Protein 1, Long Isoform|BCL2L1|Bcl2-Related Protein, Long Isoform	Like bcl-2 bcl-xL acts as a repressor of apoptosis.  bcl-xL mediates the closure of the mitochondrial porin channel VDAC and thus regulates the release of cytochrome c during apoptosis.
C17699	BCL2-Associated_X_Protein	Apoptosis_Promoter	BCL2-Associated X Protein|BAX|BAX Isoform Alpha|BAX Protein	The BAX gene produces at least four proteins by alternate splicing: membrane-bound alpha and cytoplasmic beta, gamma, and delta; all bind and antagonize BCL2, which represses programmed cell death.  Pro-apoptotic BAX acts as a partner of BCL2, shows extensive homology with BCL2, and forms homodimers and heterodimers with BCL2.  Pro-apoptotic BAX and BAK proteins accelerate opening of the mitochondrial porin channel, VDAC.  BAX appears to interact, and cooperate, with the constitutive pro-apoptotic ANT mitochondrial protein within the pore complex to increase mitochondrial permeability, allowing cytochrome C passage and triggering cell death. Expression of BAX is a significant prognostic factor in patients with gastric lymphoma.  Its prognostic value increases significantly when studied in BCL2-negative patients.  (from OMIM 600040 and NCI)
C17700	CRKL_Protein	Protein_Tyrosine_Kinase	CRKL Protein|CRK-Like Protein|CRKL	Proto-oncogene coding for the macrophage colony-stimulating factor 1 receptor, a receptor tyrosine kinase.  Homolog of the v-fms McDonough feline sarcoma oncogene.
C17701	GLI_Family_Protein	Transcription_Factor	GLI Family Protein|GLI Protein|Glioma Associated Oncogene Homolog Protein	A group of DNA-binding proteins that contain zinc finger repeats and involves pattern formation process.
C17702	Biosynthesis	Metabolic_Process	Biosynthesis|Anabolism	Formation of a chemical compound by enzymes, either in the organism (in vivo) or by fragments or extracts of cells (in vitro).
C17703	Teratology	Embryology	Teratology
C17704	Tokelau	Country	Tokelau|772|TK|TKL|TL|Union Islands	A group of three atolls in the South Pacific Ocean, about one-half of the way from Hawaii to New Zealand. (CIA World Factbook 2002)
C17705	Training	Training_and_Education	Training|Training Programs	To teach with hands-on experience
C17706	Anergy	Immune_Function	Anergy	Diminished immune responsiveness to specific antigens; induced or programmed clonal lymphocyte anergy is believed to be the second major mechanism (after clonal deletion) of the development of self tolerance by the immune system.
C17707	Thrombopoiesis	Myelopoiesis	Thrombopoiesis|Thrombocytopoiesis	The formation of thrombocytes or blood from megakaryocytes. In the bloodstream, platelets bind to fibrinogen at the site of a wound to initiate the blood clotting process.
C17708	Physical_Activity	Health_Behavior	Physical Activity	Any form of exercise or movement. Physical activity may include planned activity such as walking, running, basketball, or other sports. Physical activity may also include other daily activities such as household chores, yard work, walking the dog, etc. (from NIDDK Glossary; http://www.niddk.nih.gov/health/nutrit/pubs/glossary/glossaryintro.htm)
C17709	Cell-Mediated_Cytolysis	Immune_Response	Cell-Mediated Cytolysis|Cell-Mediated Cytotoxicity|Cell-Mediated Lympholysis|Cellular Cytotoxicity|Cytotoxicity, Immunologic|Lymphocyte Cytotoxicity|Lymphocytotoxicity	The phenomenon of antibody-mediated target cell destruction by non-sensitized effector cells. The identity of the target cell varies, but it must possess surface IgG whose Fc portion is intact. The effector cell is a "killer" cell possessing Fc receptors. It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage, or polynuclear leukocyte, depending on the identity of the target cell. The reaction is complement-independent.
C17710	Subcellular_Process	Biological_Process	Subcellular Process|Cell Process	An intracellular or extracellular function, activity, or process principally involving intracellular or extracellular components. (NCI)
C17711	Prokaryotic_Cell_Component	Specimen	Prokaryotic Cell Component
C17712	Immunologic_Tolerance	Pathologic_Process	Immunologic Tolerance|Tolerance|immune system tolerance	The failure of an organism to mount an immune response to an antigen. There are two primary types of immunological tolerance. The first type is an innate tolerance that prevents the body from attacking native proteins and tissue. The second type of tolerance is induced by exposure to foreign entities that entails the manipulation of the immune response to enable transplanted organ acceptance or to prevent allergic reactions.
C17713	Personality_Trait	Personal_Attribute	Personality Trait|Personality Traits	The characteristics in behavior that a certain person has.
C17715	Substance_Abuse_Other	Substance_Abuse	Substance Abuse, Other
C17716	Discipline	Business_Rules	Discipline	Activities designed to promote appropriate behavior, conduct, or action including time out, limits, and controls.
C17717	Support_System	Social_Concepts	Support System|Social Support System	The circle of friends, family, and associates that provide love, care, and need gratification including church, school, and workplace. (OMS94)
C17718	Uninsured_Medical_Expense	Insurance_and_Payment_Issues	Uninsured Medical Expense|Out-of-Pocket Expense	Uninsured Medical Expense; payment for the uninsured portion of regular medical expenses, such as co-payments, deductibles, and uncovered expenses. Uninsured medical expense encompasses a range of items that includes co-payments, medicine costs, uncovered procedures and conditions, as well as cash payments in lieu of health insurance.
C17719	Individual	Retired_Concepts	Individual|IND|INDS|Individuals	A single human being.
C17720	Gynecologist	Medical_Occupation	Gynecologist|gynecologist	(guy-neh-KAH-lo-jist) A doctor who specializes in treating diseases of the female reproductive organs.
C17721	Neurologist	Medical_Occupation	Neurologist|neurologist	(noo-ROL-o-jist) A doctor who specializes in the diagnosis and treatment of disorders of the nervous system.
C17722	Neurosurgeon	Surgeon	Neurosurgeon|neurosurgeon|surgeon, neuro-	(NOO-ro-SER-jun) A doctor who specializes in surgery on the brain, spine, and other parts of the nervous system.
C17723	Pathologist	Medical_Occupation	Pathologist|pathologist	(pa-THOL-o-jist) A doctor who identifies diseases by studying cells and tissues under a microscope.
C17724	Rural	Community	Rural	Of or pertaining to the country as opposed to the city. (American Heritage Dictionary)
C17725	Sun_Exposure	Environmental_and_Occupational_Exposure	Sun Exposure	The exposure to incident light from the sun.
C17726	Family_Medical_History	Personal_Medical_History	Family Medical History|Epidemiology, Family Medical History|FH|Family History|Family History of	A record of a patient's background regarding health and disease events of blood relatives.  A patients family medical history may be important in diagnosing existing conditions. (NCI)
C17727	Pacific_Island_American	Retired_Concepts	Pacific Island American|Pacific Island Americans|Pacific-Islander	Pacific Island American - a person having origins in any of the original peoples of Hawaii, Guam, Samoa, or other Pacific Islands and who was either born in the United States or who was naturalized as a citizen of the United States. The concept refers also to individuals who classify themselves as described below.
C17728	Ligand_Binding_Protein	Protein_Organized_by_Function	Ligand Binding Protein|Binding Protein	General term for proteins that have binding as a major function.
C17729	Organogenesis	Developmental_Process	Organogenesis	Formation of organs during development.
C17730	Fetal_Tissue	Tissue_Sample	Fetal Tissue	Any tissue from a fetus.
C17731	Immunocytochemistry	Cytochemistry	Immunocytochemistry	A laboratory tissue staining procedure involving monoclonal or polyclonal antibodies that react with specific tissue antigens.  Initially used as a research tool, immunocytochemistry has become routine in diagnostic work-up of diseases in pathology. -- 2004
C17732	Visible_Light	Nonionizing_Radiation	Visible Light|Radiation, Visible Light	Electromagnetic radiation in the portion of the spectrum from about 380 nm (violet) to 800 nm (red).
C17733	Palau	Country	Palau|585|PLW|PS|PW	A country in the Pacific, comprising a group of islands in the North Pacific Ocean, southeast of the Philippines. (CIA World Factbook 2002)
C17734	At-Risk_Population	Population_Group	At-Risk Population	Population groups with an increased likelihood of a disease or other health issue, eg smoking, drug use, teen pregnancy.
C17735	Policy	Sociology	Policy|Public Policy	A plan or course of action designed to influence and determine decisions and actions as related to health or disease in organizations. (WEBS84)
C17736	Thyroid_Hormone_Receptor_Beta	Thyroid_Hormone_Receptor	Thyroid Hormone Receptor Beta|ERBA Beta Protein|ERBA2 Protein|THRB|THRB Protein	Thyroid Hormone Receptor Beta comprises at least two dimeric thyroid hormone receptor transcription factors expressed in liver and some other tissues.  The receptor encoded by gene ERBA2 (THR1, THRB) on chromosome 3 is one form of the thyroid hormone receptor beta. Separated from ERBA2 by 50-120 kb, the ERBA1 locus encodes a second beta form of the receptor.  (from OMIM 190160 and NCI)
C17737	Sperm_Preservation	Preservation_Technique	Sperm Preservation	Methods for short or long term preservation of sperm cells, such as cryopreservation in liquid nitrogen. (NCI/OSP)
C17738	Fluorescence_Spectroscopy	Spectroscopy	Fluorescence Spectroscopy|Spectroscopy, Fluorescence	Fluorescent spectroscopy or fluorometry is a type of electromagnetic spectroscopy used for analyzing fluorescent spectra. It involves using a beam of light, usually ultraviolet light, that excites the electrons in molecules of certain compounds and causes them to emit light of a lower energy, typically, but not necessarily, visible light. (From Wikipedia)
C17739	American_Samoa	Country	American Samoa|016|AQ|AS|ASM	A group of islands in the South Pacific Ocean, about half way between Hawaii and New Zealand. (CIA World Factbook 2002)
C17740	Samoa	Country	Samoa|882|WS|WSM	A group of islands in the South Pacific Ocean, about one-half of the way from Hawaii to New Zealand. (CIA World Factbook 2002)
C17741	Oxidative_Stress	Cellular_Stress	Oxidative Stress|oxidative stress	A condition in which antioxidant levels are lower than normal. Antioxidant levels are usually measured in blood plasma.
C17742	Gene_Targeting	Molecular_Biology_Techniques	Gene Targeting	A technique that involves integration of an exogenous DNA sequence encoding a specific gene into the genome of an organism by homologous recombination.
C17743	Genomic_Imprinting	Epigenetic_Process	Genomic Imprinting	Parent specific expression or repression of genes or chromosomes in offspring. (On-line Medical Dictionary)
C17744	Homeodomain_Protein	Retired_Concepts	Homeodomain Protein
C17745	Multidrug_Resistance	Drug_Resistance	Multidrug Resistance|Multiple Drug Resistance|multidrug resistance	Adaptation of tumor cells to anticancer drugs in ways that make the drugs less effective.
C17746	P-Glycoprotein-1	ABC_Transporter	ATP-Binding Cassette, Sub-Family B, Member 1|ABCB1|MDR1 Protein|Multidrug Resistance 1|P-Glycoprotein 1|P-Glycoprotein Transporter	Human p-glycoprotein-1 (1280 aa, 141 kDa) is encoded by the human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) gene. The protein is an ATP-dependent, transmembrane transport/efflux pump glycoprotein that is expressed in liver, kidney, small intestine and brain.
C17747	Disease_Progression	Pathologic_Process	Disease Progression|Progression|disease progression|progression	Cancer that continues to grow or spread.
C17748	Reproductive_Medicine	Medicine	Reproductive Medicine
C17749	Photobiology	Radiation_Biology	Photobiology|Radiation Biology, Photobiology	The branch of biology dealing with the effect of light on organisms.
C17750	ABC_Transporter	Permease	ABC Transporter|ABC Transport Protein|ABC Transporter Protein|ATP Binding Cassette Transporter	ABC transporters consist of two integral membrane proteins (permeases) each having six transmembrane segments, two peripheral membrane proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. The ATP-binding protein component is the most conserved, the membrane protein component is somewhat less conserved, and the substrate-binding protein component is most divergent.
C17751	Disease-Free_Survival	Survival	Disease-Free Survival|disease-free survival	Length of time after treatment during which no cancer is found. Can be reported for an individual patient or for a study population.
C17752	Fee_for_Service	Medical_Economics	Fee for Service	In health care, a payment mechanism in which a provider is paid for each individual service rendered to a patient. (MedicineNet.com)
C17753	Confocal_Microscopy	Light_Microscopy	Confocal Microscopy	A system of (usually) epifluorescence light microscopy in which a fine laser beam of light is scanned over the object through the objective lens. The technique is particularly good at rejecting light from outside the plane of focus and so produces higher effective resolution than is normally achieved. (On-line Medical Dictionary)
C17754	Atomic_Force_Microscopy	Atomic_Resolution_Microscopy	Atomic Force Microscopy|AFM|Atomic Force Microscope	An atomic force microscope measures the attractive or repulsive force between a sample surface and a sharp tip. The tip is attached to a cantilever, and the displacement of the cantilever is measured as the tip is scanned across the sample, leading to surface visualization.  AFMs can give images with a resolution of 10 pm, and can scan samples in air and under liquids.(MATTER Glossary; http://www.matter.org.uk/glossary/)
C17755	Toxicity_Test	Biological_Testing	Toxicity Test|Toxicity Testing	Controlled laboratory tests to determine the toxicity of a chemical to an organism in terms of specific chemical concentrations. (On-line Medical Dictionary)
C17756	ERBB2_Gene	Receptor_Tyrosine_Kinase_Gene	ERBB2 Gene|ERBB2|HER|HER2|HER2/neu|Human EGF Receptor 2 Gene|NEU Gene|NGL|TKR1|V-ERB-B2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/glioblastoma Derived Oncogene Homolog (Avian) Gene|c-ERBB-2	Human v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian) (ERBB2) gene, located at 17q21.1, encodes receptor tyrosine-protein kinase erbB-2 protein. Amplification of the ERBB2 gene is involved in the progression of several forms of breast cancer. Elevated levels of erbB-2 protein have also been detected in ovarian tumors.
C17757	EGFR_Gene	Receptor_Tyrosine_Kinase_Gene	EGFR Gene|EGFR|EGFR, Gene|ERBB|ERBB1|ERBB1 Gene|Epidermal Growth Factor Receptor (Erythroblastic Leukemia Viral (V-ERB-B) Oncogene Homolog, Avian) Gene	The EGFR gene at chromosome 7p12.3-p12.1 encodes the EGF receptor, a cell surface transmembrane protein tyrosine kinase involved in regulation of cell growth and differentiation. The gene is not expressed in mitotically quiescent cells, except in the stomach where it controls the synthesis and release of digestive enzymes and gastric acid. EGFR tyrosine kinase activity is required for internalization or degradation of EGF-EGFR receptor complexes. EGFR signaling involves small RHO GTPases and EGFR trafficking involves small RAB GTPases.
C17758	Oncogene_ERB-A	THRB_Gene	Oncogene ERB A|Avian Erythroblastosis Virus Oncogene A|ERBA-ALPHA|Erythroblast Transforming Gene A|Thyroid Hormone Receptor Alpha-1, Oncogene	Two ERBA proto-oncogenes located on separate chromosomes, encode ERBA alpha and ERBA beta, which are thyroid hormone receptors in the nucleus and bind DNA to activate transcription. Multiple thyroid hormone receptor (THR) genes may be encoded in the human genome and perhaps as many as five loci with varying expression in different tissues and stages of development. The ERBA1 gene at 17q11.2 encodes ERBA alpha-1, ERBA alpha-2, and ERBA alpha-3, each produced by alternative splicing. All ERBA1 transcripts are coordinately expressed. The ERBA2 gene at 3p24.3 encodes ERBA beta-1 and a neighboring gene encodes ERBA beta-2. The TH receptor expressed in the mammalian CNS and most other tissues (except liver) is encoded by ERBA1. The receptor present in liver (the major TH-responsive organ) and some other tissues is encoded by ERBA2. Point mutations in the ERBA2 gene are associated with generalized resistance to thyroid hormone.
C17759	Radiology_Therapeutic	Radiology	Therapeutic Radiology|Radiology, Therapeutic	A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease.
C17760	Radiation_Oncology	Oncology	Radiation Oncology|oncology, radiation
C17761	Cell_Cycle_Protein	Regulatory_Protein	Cell Cycle Protein	Proteins involved in the process of cell division. Numerous proteins of different functionality and type are involved in this process.
C17762	Single-Stranded_Conformational_Polymorphism	Genetic_Polymorphism	Single-Stranded Conformational Polymorphism|Polymorphism, Single-Stranded Conformational|SSCP	A Single-Stranded Conformational Polymorphism consists of nucleotide sequence variation in the same region of DNA between individuals within a species, or between alleles in an individual, that cause partially denatured DNA fragments to take on different conformations as a result of their nucleotide sequences differences. These conformation differences can be detected through various gel-separation techniques.
C17763	Oncogene_ERB-B	EGFR_Gene	Oncogene ERB B|Avian Erythroblastosis Virus Oncogene B|ERB-B|Erythroblast Transforming Gene B|Oncogene, EGFR	ERBB DNA sequences are related to certain avian erythroblastosis virus sequences. The cellular genes encode members of the epidermal growth factor receptor (EGFR) family (ERBB1, 2, 3, and 4). The 110-kb EGFR gene locus encodes the EGF receptor, a cell surface transmembrane protein tyrosine kinase involved in regulation of cell growth and differentiation. ERBB2, ERBB3, and ERBB4 genes encode heregulin/neuregulin receptor tyrosine kinase homo- and heterodimers important in the control of cell proliferation and in the pathogenesis of human cancers. ERBB proteins are over expressed in a significant portion of adenocarcinomas at various sites, especially in the breast; gene amplification appears to be the predominant cause of over expression. Oncogene ERBB2 encodes tumor antigen p185. The human ERBB1 gene is located at 7p12.3-p12.1, ERBB2 is located at 17p12-21, ERBB3 is located at 12q13, ERBB4 is located at 2q33.3-q34.
C17764	Chaperone	Protein_Organized_by_Function	Chaperone|Molecular Chaperone	Cytoplasmic proteins of both prokaryotes and eukaryotes that bind to nascent or unfolded polypeptides and ensure correct folding or transport. Chaperone proteins do not covalently bind to their targets and do not form part of the finished product. Heat-shock proteins are an important sub set of chaperones. Three major families are recognised, the chaperonins (groEL and hsp60), the hsp70 family and the hsp90 family. Outside these major families are other proteins with similar functions including nucleoplasmin, secB and T-cell receptor associated protein. (On-line Medical Dictionary)
C17765	Heat_Shock_Protein-70	Chaperone	Heat Shock Protein 70|70-kD Heat Shock Protein|70-kD Heat-Shock Protein|HSP 70|HSP-70|HSP70	Heat Shock Protein 70 is a class of conserved molecular chaperone proteins in both prokaryotes and eukaryotic cells that may interact with polypeptides during the assembly processes to prevent the formation of nonfunctional structures.  There are at least three HSP70 loci in the human genome, which map to chromosomes 6, 14, 21, and at least one other chromosome.  Heat-shock proteins are expressed in response to a variety of stresses.  The human HSP70 multi-gene family encodes highly conserved 70 kD proteins with structural and functional properties in common, but which vary in their response to metabolic stress.  Some mRNAs are rapidly degraded through an AU-rich 3-prime untranslated region bound by AUF1, which complexes with HSC70, HSP70, EIF4G, and poly(A)-binding protein.  The mRNA decay is associated with displacement of EIF4G from AUF1, ubiquitination of AUF1, and degradation.  HSP70 blocks decay of AU-rich mRNAs and AUF1 protein.
C17766	Heat_Shock_Protein-90	Chaperone	Heat Shock Protein 90|HSP-90|HSP90	The Heat Shock Protein 90 members HSP89-alpha and HSP89-beta are a class of cytoplasmic molecular chaperone homodimers that act in the signal transduction mechanism of steroid receptors and may have ATPase activity.  CDC37 and HSP90 associate preferentially with CDK4 not bound to type D cyclins.  HSPA8, HSP90A, CXCR4, and GDF5 on monocytes form an activation cluster after LPS ligation and are involved in LPS signal transduction.  (from OMIM 140571, Swiss-Prot P07900, P08238, and NCI)
C17767	Cyclin-Dependent_Kinase	Cell_Cycle_Protein	Cyclin-Dependent Kinase|Cyclin Dependent Kinase	Cyclin-dependent kinases are eukaryotic, phosphoregulated protein kinases that associate with cyclins to control cell cycle progression.
C17768	Cellular_Morphology	Morphology	Cellular Morphology|Cell Morphology|Morphology, Cellular	Cellular morphology is the form and structure of cells, and its relation to cell function, or the scientific study thereof.
C17769	Funding	NCI_Administrative_Concepts	Funding	A sum of money or other resources set aside for a specific purpose. (American Heritage Dictionary)
C17770	Development	Reproductive_Process	Development	Development is the act, or process, of natural progression in physical and psychological maturation from a previous, lower, or embryonic stage to a later, more complex, or adult stage.
C17771	Chemical_Properties	Attributes_of_Chemicals	Chemical Properties	general term for compositional, structural, and reactivity- affecting qualities of chemical compounds.
C17772	CD44_Antigen	Cell_Adhesion_Molecule	CD44 Antigen|CD44|CD44 Adhesion Receptor|HUTCH-1|Hermes Antigen|gp85	CD44, encoded by the CD44 gene and expressed as isoforms generated from alternative splicing and posttranslational modifications, is an acidic sulfated integral membrane glycoprotein that mediates cell-matrix adhesion, lymphocyte activation, lymph node homing, and immune cell cytokine release. Certain isoforms that regulate lymphocyte and macrophage activation and migration may enhance growth and metastatic spread of tumor cells, and may be useful in detection and diagnosis of cancer. Expressed on various cells, CD44 is the main receptor for hyaluronate. Hyaluronate enhances homotypic cellular aggregation while another ligand, osteopontin, induces cellular chemotaxis. CD44 functions in a growth factor presentation mechanism necessary for limb development. Streptococcus binding to CD44 on keratinocytes induces host cytoskeletal rearrangements and disruption of intercellular junctions, promoting tissue penetration by bacteria. (from OMIM and NCI)
C17773	Arylamine_N-Acetyltransferase-2	Acyltransferase	Arylamine N-Acetyltransferase 2|Arylamine Acetylase|EC 2.3.1.5|N-Acetyltransferase|NAT2|Serotonin N-acetyltransferase	Arylamine N-acetyltransferase, the encoded product of the NAT2 gene, is the polymorphic enzyme responsible for the "acetylator phenotype"; rapid or slow acetylation of therapeutic and carcinogenic agents is due to variation at the NAT2 locus.  The slow phenotype results from decreased or absent arylamine N-acetyltransferase in the liver.  A relationship appears to exist between acetylator phenotype and DNA damage by chemicals that undergo N-acetylation.  Acetylation polymorphism may be a factor in susceptibility to toxicity and perhaps carcinogenicity of target chemicals.  (from OMIM 243400 and NCI)
C17774	TACSTD2_Gene	Receptor_Gene	TACSTD2 Gene|EpCAM|GA733-1|M1S1|TACSTD2|TROP2|Tumor-Associated Calcium Signal Transducer 2 Gene	The Tumor-Associated Calcium Signal Transducer 2 (TACSTD2) Gene, a member of the GA733 gene family, encodes a type I membrane protein (with extracytoplasmic domain, transmembrane region, and cytoplasmic domain) that may function as a growth factor receptor. The TACSTD2 gene contains one thyroglobulin type-I domain and a single exon that encodes a predicted 35.7-kD protein with four potential N-linked glycosylation sites and a conserved potential cytoplasmic phosphorylation site. TACSTD2 is expressed in the cornea as well as in kidney, lung, placenta, pancreas, prostate, gastrointestinal tumors, and pancreatic carcinoma cell lines.  Deletion or truncation of the gene product appears to be associated with Gelatinous Drop-Like Corneal Dystrophy, an autosomal recessive disorder characterized by grayish corneal amyloid deposits that cause severe visual impairment. The human gene is located at chromosome 1p32-p31.
C17775	Telomeric-Repeat_Binding_Factor	DNA_Binding_Protein	Telomeric-Repeat Binding Factor|TRF Protein	Human telomeric-repeat binding factor proteins (TRF) 1 and 2 are involved in the control of telomere dynamics in vivo.  Reduced expression of TRF1 and TRF2 mRNAs was observed in human malignant hematopoietic and acute leukemia cell lines.  However, expression of TRF1 and TRF2 mRNAs increased during differentiation of malignant hematopoietic cell line when induced artificially.  Furthermore, studies from gastrointestinal carcinogenesis suggested that down-regulation of the TRF1 expression in tumor cells may be involved in cell immortalization. Together with hTERT, TRF1 and TRF2 are important regulators of telomerase activity and represent potential targets for cancer therapy.
C17776	FAS_Antigen	TNF_Receptor_Family_Protein	Tumor Necrosis Factor Receptor Superfamily, Member 6|APO-1 Cell Surface Antigen|Apoptosis Antigen 1|CD95 Antigen|Fas Antigen|TNFRSF6	FAS differentiation antigen is expressed in the thymus, liver, ovary, and heart, and on a variety of cell lines including myeloid and lymphoblastoid cell lines. Its primary role is to regulate T-cell development in the thymus and to regulate peripheral immune responses, by triggering apoptosis.  FAS is a member of the TNFR/NGFR superfamily.  Activation of FAS by FAS ligand results in the formation of a death-inducing signaling complex with the signal adaptor protein FADD and with procaspase 8.  This association generates CASP8, activating a cascade of caspases.  (from OMIM 134637 and NCI)
C17777	BCL6_Protein	Retired_Concepts	BCL6 Protein|B-Cell Lymphoma 6 Protein|LAZ3|Lymphoma-Associated Zinc Finger Gene on Chromosome 3|ZNF51|Zinc Finger Protein 51	BCL6 protein is may be a transcription factor and contains six zinc finger motifs and shares an N-terminal POZ domain homologous to other transcription factors. BCL6 protein is predominantly expressed in the B-cell lineage and found in mature B cells. BCL6 is expressed in germinal centers, including all centroblasts and centrocytes. BCL6 is present in DNA-binding complexes and can repress transcription and its activity is dependent upon DNA-binding and on the N-terminal region containing the POZ motif. Target genes have roles in B-cell activation (CD69, CD44, EBI2, ID2, LEU13, and STAT1), B-cell differentiation (BLIMP1, CD10, AMYB, BCL7A, CD19, and CD20), inflammation (MIP1A, IP10, and CXCR4), and cell cycle control (p27(KIP1) and cyclin D2). Expression of BCL6 in some B-cells early in the antigen response may skew them toward a germinal center fate, away from a plasma cell fate. (from OMIM 109565 and NCI)
C17778	Proteasome-26S_Subunit_Non-ATPase-10	Protein_Complex_Subunit	Proteasome 26S Subunit Non-ATPase 10|26S Proteasome Regulatory Subunit p28|Gankyrin|Hepatocellular Carcinoma-Associated Protein p28-II|PSMD10	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. This protein is a non-ATPase subunit of the 19S regulator. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. (from LocusLink)
C17779	FADD	Retired_Concepts	FADD|FAS-Associated Protein with A Death Domain|MORT-1
C17780	MAP-Kinase-8	Mitogen-Activated_Protein_Kinase	MAP Kinase 8|JN Kinase|JNK1 Protein|MAPK8|SAPK/JNK|SAPK1|SAPK1/JNK|Stress-Activated Protein Kinase 1|c-JUN N-Terminal Kinase	Encoded by Human MAPK8 Gene (MAPK Family) as alternative isoforms (alpha-1, -2, beta-1, -2), MAP Kinase 8 is a stress/cytokine-induced Ser/Thr kinase that acts as an integration point for multiple biochemical signals involved in target transcription factor regulation, such as c-Jun and ATF2. Beta-1 binds c-Jun; alpha-1, -2, and beta-2 bind c-Jun or ATF2. Inhibited by dual specificity phosphatases, and phosphothreonine/tyrosine activated by a Ras-dependent dual specificity MAP2K4/MAP2K7 cascade, MAPK8 mediates immediate-early gene expression. MAPK8 binds scaffolding proteins MAPK8IP1/2/3. MAPK8/UV-induced apoptosis appears related to cytochrome c-mediated cell death. MAPK8 activation by TNF-alpha induces apoptosis. MAPK8 appears to be required for T-helper cell differentiation into Th1 cells. (NCI)
C17781	RRAD_Protein	RAS_Superfamily_Protein	RRAD Protein|RAD|RAD Protein|Ras-Related Associated with Diabetes Protein	RRAD protein is a novel 29 kD member of the RAD/GEM family in the RAS-guanosine triphosphatase superfamily.  It is expressed in skeletal and cardiac muscle, lung, and lesser amounts in placenta and kidney.  RRAD is selectively over expressed in type II diabetic muscle as compared to muscle of non-diabetic or type I diabetic individuals.  (from OMIM 179503, SWISS-PROT P55042, and NCI)
C17782	CDKN1A_Gene	Cyclin-Dependent_Kinase_Inhibitor_Gene	CDKN1A Gene|CAP20|CDKN1|CDKN1A|CIP1|Cyclin-Dependent Kinase Inhibitor 1A Gene|P21|SDI1|WAF1	The CDKN1A gene encodes a cyclin-dependent kinase inhibitor 1A product, which inhibits cyclin kinase activity and may be the p53 effector of cell cycle control.  This gene is transcriptionally regulated by p53 and IFN beta.  The human gene is located at 6p21.2.
C17783	Cyclin-Dependent_Kinase_Inhibitor-1A	Cyclin-Dependent_Kinase_Inhibitor	Cyclin-Dependent Kinase Inhibitor 1A|CDK-Interacting Protein 1|CDKN1A|CDKN1A Protein|CIP-1 Protein|MDA 6|WAF-1 Protein|p21	May mediate p53 inhibition of cell proliferation in response to DNA damage. CIP1 appears to be a tight-binding inhibitor of CDKs. CDKN1A expression is tightly regulated by p53 and IFN-Beta. The CIP1 N-terminus is similar to KIP1. CIP1 is truncated by CASP3 in apoptosis. (from SWISS-PROT P38936, OMIM 116899, and NCI)
C17784	Cyclin-Dependent_Kinase-4_Inhibitor-B	Cyclin-Dependent_Kinase_Inhibitor	Cyclin-Dependent Kinase 4 Inhibitor B|CDK4B Inhibitor|CDKN2B|CDKN2B Protein|CDN5|Cyclin-Dependent Kinase Inhibitor 2B|MTS2 Protein|Multiple Tumor Suppressor 2|P14-INK4B|P15-INK4B|TP15	Induced by TGF-beta, cyclin-dependent kinase 4 inhibitor B interacts with CDK4 and CDK6, and may mediate TGF-Beta induced cell cycle arrest.  CDK4IB contains two ankyrin repeats and belongs to the CDKN2/p16(INK4) family.  (from SWISS-PROT P42772, OMIM 600431, and NCI)
C17785	Cyclin-Dependent_Kinase-5	Cyclin-Dependent_Kinase	Cyclin-Dependent Kinase 5|CDK5|Cell Division Kinase 5|Cell Division Protein Kinase 5|Cyclin-Dependent Kinase-5|Serine/Threonine-Protein Kinase PSSALRE|TPKII Catalytic Subunit|Tau Protein Kinase II Catalytic Subunit	A hetero-dimeric (catalytic/regulatory subunits) serine/threonine protein kinase involved in cell cycle control. Predominantly neuronal, Cdk5 belongs to the CDC2/CDKX subfamily, interacts with D1- and D3-type G1 Cyclins, and phosphorylates histone H1, Tau, Map2, NF-H, and NF-M. (from SWISS-PROT Q00535, OMIM 123831, and NCI)
C17786	Cyclin-Dependent_Kinase_Inhibitor-2A	Cyclin-Dependent_Kinase_Inhibitor	Cyclin-Dependent Kinase Inhibitor 2A|CDK4 Inhibitor|CDK4I|CDKN2A|CDKN2A Protein|Cell Cycle Negative Regulator Beta|Cyclin-Dependent Kinase Inhibitor p12|Cyclin-Dependent Kinase Inhibitor p16|MTS1|MTS1 Protein|Multiple Tumor Suppressor 1|P16(INK4A)|p14(ARF)|p16(INK4)|p16-INK4|p16-INK4a|p19(ARF)	Product of the CDKN2A gene.  Also called p16(INK4).  A tumor suppressor and a negative regulator of progression through G1.  p16(INK4) interacts with CDK4/CDK6, inhibiting their interaction with Cyclin D and the phosphorylation of RB.
C17788	M_Protein	Pathologic_Ab-Ig_Protein	M Protein|M Proteins|M proteins|Monoclonal immunoglobulin	A protein complex comprised of two heavy chains and two light chains. Monoclonal immunoglobulin (M protein) is found in abundance in patients who have multiple myeloma. The protein is not produced in response to an antigen, but it is expressed in malignant plasma cells and excreted into the blood and urine.
C17789	SDF1-PBSF_Receptor-CXCR4	Chemokine_Receptor	SDF1/PBSF Receptor CXCR4|C-X-C Chemokine Receptor Type 4|CD184 Antigen|CXCR4|CXCR4 Receptor|Chemokine (C-X-C Motif) Receptor 4|Chemokine, CXC Motif, Receptor 4|Fusin|LPS-Associated Protein 3|Leukocyte-Derived Seven Transmembrane Domain Receptor|Lipopolysaccharide-Associated Protein 3|Neuropeptide Y Receptor Y3|SDF-1 Receptor|Seven-Transmembrane-Segment Receptor, Spleen|Stromal Cell-Derived Factor 1 Receptor	CXCR4 shares features common to G protein coupled receptors.  CXCR4 is a receptor for the CXC chemokine PBSF/SDF1 and functions as a co-receptor for HIV-1.  CXCR4 is broadly expressed in the immune and the central nervous systems and can mediate migration of resting leukocytes and hematopoietic progenitors in response to SDF1.  PBSF/SDF1 and CXCR4 define a signaling system for organ vascularization.  (from OMIM 162643 and NCI)
C17790	Maspin	Cell_Adhesion_Molecule	Maspin|PI5|Protease Inhibitor 5|SERPINB5	Maspin is a member of the Serpin protein family. Unlike other members of the family, Maspin exhibits no protease inhibitory activity (see J Biol Chem. 2002 Dec 6;277(49):46845-8. Epub 2002 Oct 15), but it plays a role in cell-matrix adhesion, tumor invasion, and metastasis.  High maspin expression appears to oppose lymph node metastasis.  Higher expression is associated with better survival rates and may be a favorable prognostic marker. (from SWISS-PROT, OMIM, and NCI)
C17791	DAN_Protein	Transcription_Factor	DAN Protein|NBL1|Neuroblastoma Suppressor of Tumorigenicity 1|Zinc Finger Protein DAN	DAN protein (Differential screening-selected gene Aberrant in Neuroblastoma) is a putative transcription factor that may prevent cells from entering final G1/S stage.  (from OMIM 600613 and NCI)
C17792	Collagen_XVIII_Alpha-1	Collagen	Collagen XVIII (Alpha 1)|COL18A1|COL18A1 Protein|Collagen Alpha1 (XVIII)|Collagen, Type XVIII, Alpha 1	Collagen XVIII (Alpha 1), encoded by the human COL18A1 gene, is the alpha chain of type XVIII collagen. Mutations in this gene are a cause of Knobloch syndrome. The main features of this syndrome involve retinal abnormalities and this protein may play an important role in retinal structure and in neural tube closure. There is an association between a polymorphism in position 1437 and prostate cancer. Three transcripts have been identified for this gene as a result of alternate promoter utilization and alternative splicing. A long variant predominates in liver, while a short variant is present in conventional basement membranes. This protein is present in multiple organs with highest levels in liver, lung and kidney. The proteolytically produced C-terminal fragment of Collagen XVIII (Alpha 1) is endostatin, a potent antiangiogenic protein. (From LocusLink, Swiss-Prot, and NCI)
C17793	Growth_Arrest_and_DNA-Damage-Inducible_Alpha_Protein	Signaling_Protein	Growth Arrest and DNA-Damage-Inducible, Alpha|GADD45 Gene Product|GADD45A|GADD45A Protein|Growth Arrest and DNA Damage-Inducible Gene 45 Protein	Growth Arrest and DNA-Damage-Inducible, Alpha, encoded by the GADD45A gene, is widely expressed in normal tissues and its expression is increased by DNA damage. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. The GADD45A protein responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. This nuclear protein interacts with the proliferating cell nuclear antigen (PCNA), a component of DNA replication/repair complexes, and the cyclin dependent kinase inhibitor p21Cip1.
C17794	MLH1_Protein	Retired_Concepts	MLH1 Protein|MLH1 Gene Product|MUTL Protein Homolog 1|Mismatch DNA Repair Protein MLH1|hMLH1 Protein	MLH1 protein is a DNA-binding, DNA-mismatch repair protein, of the MutL/HexB family, that dimerizes with PMS2 or MLH3.  MLH1 is part of the multi-subunit BASC repair complex containing ATM, BLM, MSH2, MSH6, BRCA1, the RAD50/MRE11/NBS1 complex, and the RFC1/RFC2/RFC4 complex.  MLH1 is homologous to MutL, which hydrolyzes ATP.  (from OMIM 120436 and NCI)
C17795	ISWI	Drosophila_Protein	ISWI|Imitation Switch	The Drosophila gene Imitation SWI (Iswi) encodes a DNA helicase involved in chromatin modeling. It contains a SNF2 related domain, a MYB DNA binding domain, a DEAD/DEAH box helicase, and a helicase C-terminal domain. Iswi is a component of NURF, a nucleosome remodeling complex that facilitates the perturbation of chromatin structure in an ATP-dependent manner. The hydrolysis of ATP during the remodeling of chromatin is mediated by Iswi. It is also a component of the ATP-utilizing chromatin assembly and remodeling factor ACF and of the chromatin accessibility complex CHRAC. This subunit serves as the energy-transducing component of chromatin-remodeling machines. NURF is composed of a 215 kD protein, Iswi, nurf-55, and nurf-38. Iswi belongs to the SNF2/RAD54 helicase family, SNF2L subfamily. (from FlyBase 0011604 and NCI)
C17796	Folate_Hydrolase-1	Hydrolase	Folate Hydrolase 1|GCP2|Glutamate Carboxypeptidase II|PSMA|Prostate-Specific Membrane Antigen	A transmembrane glycoprotein present in tumor-associated vasculature but not associated with normal or benign tissue.  PSMA can serve as a tumor marker as well as a target for therapy.
C17797	Merlin	Signaling_Protein	Merlin|NF2|Neurofibromin 2|Schwannomerlin|Schwannomin	Merlin protein (schwannomin, NF2 gene product) exhibits similarity to erythrocyte protein 4.1 and members of the ERM family (moesin, ezrin, and radixin), proteins thought to link cytoskeletal components with cell membrane proteins.  Mutant merlin proteins alter cell adhesion, causing cells to detach from the substratum, a possible step in the pathogenesis of NF2.  Merlin binds to the ERM-interacting phosphoprotein EBP-50.  Merlin may maintain normal cytoskeletal organization.  Schwannomin interacts with the HGF-regulated tyrosine kinase substrate HRS.  Schwannomin and HRS co-localize at endosomes suggesting that schwannomin is involved in HRS-mediated cell signaling.  (from OMIM 101000 and NCI)
C17798	TEL_Protein	ETS_Family_Protein	TEL Protein|ETS Translocation Variant 6|ETS Variant Gene 6 Protein|ETV6|ETV6 Gene Product|TEL	TEL protein is a member of the ETS family of transcription factors.  It has an HLH motif and an ETS DNA-binding domain.  Translocations of the gene produce chimeric proteins in many leukemias of myeloid or lymphoid origins.  Leukemogenic translocations often fuse the TEL HLH domain with the tyrosine kinase domain of other genes, such as PDGFRB, NTRK3, and ABL2 or with other transcription factors, such as AML1 and ARNT.  (from OMIM 600618 and NCI)
C17799	Fibroblast_Activation_Protein_Alpha	Serine_Protease	Fibroblast Activation Protein, Alpha|170-kD Melanoma Membrane-Bound Gelatinase|FAP|FAP-Alpha|Fibroblast Activation Protein, Alpha Subunit|Integral Membrane Serine Protease|Seprase	An inducible cell surface glycoprotein.  It is expressed on fibroblasts in many common epithelial cancers.  It is a gelatinase belonging to the serine protease family.  It is the target of BIBH 1 monoclonal antibody.
C17800	Tumor_Necrosis_Factor_Alpha_Receptor	TNF_Receptor_Family_Protein	Tumor Necrosis Factor Receptor Superfamily, Member 1A|TNFRSF1A|Tumor Necrosis Factor Binding Protein 1|Tumor Necrosis Factor Receptor Type 1|Tumor Necrosis Factor-Alpha Receptor	TNFR1 is a 55 kD high-affinity cell surface receptor for tumor necrosis factor.  Activated receptor interacts with death domains of TRADD to activate apoptosis and NFKB cascades.  TRADD-interacting FADD proteolytically activates caspase-8.  TNFR1 may activate PIP5K2B and may induce MAP kinase activation via MADD.  (from OMIM 191190 and NCI)
C17801	Topoisomerase-II_Alpha	Topoisomerase-II	Topoisomerase II Alpha|DNA Topoisomerase II|DNA Topoisomerase II, 170 kD|DNA Topoisomerase II, Alpha Isozyme|DNA Topoisomerase II-Alpha|TOP2A|Topo II Alpha|Topoisomerase (DNA) II Alpha (170kD)|Topoisomerase (DNA) II Alpha 170kDa|Topoisomerase, DNA, II, Alpha	Encoded by human TOP2A Gene (TOPII Family), alternative homodimeric nuclear DNA Topoisomerase II, Alpha isoforms 1 (1531-aa, 174.4-kD), 2 (1557-aa), 3 (1567-aa), and 4 (1612-aa) control DNA topology. TOP2A catalyzes transient ATP-dependent double-strand breakage/relaxation and rejoining of negative/positive supercoiled DNA during transcription, replication, chromosome condensation, and chromatid separation. TOPII reactions likely involve crossing-over. TOP2A is associated with Pol II holoenzyme. Inhibited by intercalating amsacrine, TOP2A is a target for several anticancer agents. Mutations are linked with drug resistance and perhaps ataxia-telangiectasia. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C17802	Topoisomerase-II_Beta	Topoisomerase-II	Topoisomerase II Beta|DNA Topoisomerase II, 180 kD|DNA Topoisomerase II, Beta Isozyme|TOP2B|Topo II Beta|Topoisomerase (DNA) II Beta (180kD)|Topoisomerase (DNA) II Beta 180kDa|Topoisomerase, DNA, II, Beta	Both topo II alpha and beta isoforms exhibit ATP-dependent strand passage activity, but they differ in several key aspects.  The beta isoform relaxes DNA in a more progressive manner than the alpha isoform and also exhibits a higher optimal KCl requirement.  The beta isoform has a molecular weight of 180 KD, and is immunologically distinct as well as exhibits different SV8 proteolytic cleavage pattern from alpha isoform.
C17803	CREB_Binding_Protein	Histone_Acetylase|Transcription_Coactivator	CREB Binding Protein|CBP|CREB-Binding Protein|CREBBP|Phospho-CREB Binding Protein	CREB-binding protein, a 265 kD member of a family of transcription factor co-activators now referred to as p300/CBP.  Originally identified as a nuclear protein bound by the Protein Kinase A-phosphorylated form of CREB (cAMP responsive element binding protein).
C17804	E1A_Binding_Protein-p300	Histone_Acetylase	E1A Binding Protein p300|E1A-Associated Protein p300|E1A-Associated p300 Protein|E1A-Binding Protein, 300kD|EC 2.3.1.48|EP300|p300|p300 E1A-Associated Coactivator	Important in cell proliferation and differentiation, E1A-Associated p300 Protein is a histone acetyltransferase and transcriptional co-activator/integrator that regulates transcription via chromatin remodeling. p300 contains a bromodomain, a KIX domain, and three Cys/His-rich regions. A compact IBID domain in p300 participates in ligand binding and contributes to signal integration by p300. LIF and BMP2 cytokines signal through STATs and SMADs, respectively, and act in synergy on progenitor cells to induce astrocytes. p300 interacts with STAT3 in a cytokine-independent fashion, and with SMAD1 in a cytokine-dependent manner. The formation of a p300-bridged complex between STAT3 and SMAD1 mediates cooperative LIF/BMP2 signaling and astrocyte induction. p300 also facilitates DNA repair by PCNA via chromatin remodeling at DNA lesions. p300 forms an S phase-independent complex with PCNA that stimulates DNA synthesis. (from OMIM 602700 and NCI)
C17805	Protein_Kinase-C-alpha	Protein_Kinase-C	Protein Kinase C-Alpha|PKCA|PRKCA|Protein Kinase Calpha	Encoded by human PRKCA Gene (PKC Family), 672-aa 77-kDa Protein Kinase C-alpha is a calcium-activated (likely by the C2 domain), DAG-activated, phospholipid-dependent serine/threonine kinase containing 2 zinc-dependent phorbol-ester/DAG binding domains and a C2 domain that phosphorylates a range of cellular proteins. DAG markedly increases PKC sensitivity to calcium and phospholipids. PKC activation appears to be central in the induction of cellular responses to many ligand-receptor systems and to external stimuli. After GPCR stimulation, and triggered by PKC-dependent serine phosphorylation, RKIP dissociates from RAF1 to associate with and block GRK2 activity. By activating PKC, the receptor signal may be enhanced by removing a RAF1 inhibitor and blocking receptor internalization. A receptor for phorbol ester tumor promoters, PKC may interact with PRKCABP. (NCI)
C17806	ETV3_Protein	ETS_Family_Protein	ETV3 Protein|ETS Related Protein PE-1|ETS Translocation Variant 3|ETV3|PE-1 Gene Product	ETV3 Protein, a member of the ETS proto-oncogene family of transcription factors, contains the conserved ETS domain that mediates sequence-specific DNA binding.  (from OMIM 164873 and NCI)
C17807	Prostasin	Serine_Protease	Prostasin|PRSS8|Proprostasin|Prostasin Preproprotein|Protease, Serine, 8|Serine Protease-8	Expressed in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus, and kidney epithelia, human PRSS8 Gene (Peptidase S1 Family) encodes secreted or membrane anchored 343-aa 36-kD (precursor) Serine Protease-8, similar to acrosin, plasma kallikrein, hepsin, and xCAP1 (Xenopus). The proprotein is cleaved (aa 12-13) to produce disulfide-linked light and heavy chains. The C terminal hydrophobic region is cleaved (aa 290-291) during secretion. Likely involved in semen coagulation and liquefaction, PRSS8 is active with trypsin-like specificity on Lys or Arg carboxyl peptide linkages. Prostasin may regulate ENaC. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C17808	MAP2K1_Protein	Threonine-Tyrosine_Protein_Kinase	MAP2K1 Protein|Dual Specificity Mitogen-Activated Protein Kinase Kinase 1|ERK Activator Kinase 1|MAP Kinase Kinase 1|MAP2K1|MAPK/ERK Kinase 1|MEK-1|Mitogen-Activated Protein Kinase Kinase-1	A component of the RAS intracellular signaling pathway, MAP2K1 is a critical activating protein kinase of MAP kinase.  p53 activates NFKB through a RAF/MAP2K1/p90(RSK) pathway.  (from Yu et al. Curr Biol 1998. 8:56, OMIM 176872, and NCI)
C17809	Kangai-1_Protein	Cell_Adhesion_Molecule	Kangai 1 Protein|Antigen CD82|C33 Antigen|CD82 Antigen|IA4|Inducible Membrane Protein R2|KAI1|KAI1 Protein|Leukocyte Surface Antigen R2|Metastasis Suppressor Kangai 1|Prostate Cancer Antimetastasis Gene Kai1|R2 Leukocyte Antigen|R2 Leukocyte Surface Antigen|Suppressor of Tumorigenicity 6|Suppressor of Tumorigenicity-6	Kangai 1 Protein, a metastasis suppressor protein encoded by the 80 kb human KAI1 gene (TM4SF family), is expressed in many tissues and has four putative transmembrane domains and a large extracellular domain having three potential N-glycosylation sites. KAI1 appears to be up regulated in activated T-cells. p53 activates the gene by interacting with sequences in a 5-prime upstream region. Loss of p53 appears to cause down-regulation of KAI1. Similar to leukocyte cell surface glycoproteins involved in cell adhesion and signal transduction, KAI1 is a likely homologue of mouse leukocyte surface antigen R2. Associated with CD4 or CD8, KAI1 delivers co-stimulatory signals for the TCR/CD3 pathway. KAI1 expression at the transcription or posttranscription level is often down regulated during tumor progression. (from SWISS-PROT, OMIM, and NCI)
C17810	A-MYB_Protein	Transcription_Factor	A-MYB Protein|AMYB|AMYB Protein|MYB-Related Protein A|MYBL1|MYBL1 Protein|V-MYB Avian Myeloblastosis Viral Oncogene Homolog-Like 1	A DNA-binding, transcriptional activator with a possible role in proliferation and/or differentiation of neurogenic, spermatogenic and B-lymphoid cells. A-Myb specifically recognizes the DNA sequence 5'-YAAC(G/T)G-3' and belongs to the Myb family. (from SWISS-PROT P10243, OMIM 159405, and NCI)
C17811	D10S170_Protein	Cytoskeletal_Protein	D10S170 Protein|CCDC6|D10S170|H4 Protein	The H4 gene is found fused to the RET Gene in papillary thyroid carcinoma and to platelet-derived growth factor receptor betaR in atypical chronic myeloid leukemia. The H4 gene shows no significant homology to known genes, and the function of H4 protein is unknown.  An N-terminal leucine zipper mediates dimerization of H4 protein and this dimerization is essential to transforming activity. (from OMIM 601985 and NCI)
C17812	TNF_Receptor-Associated_Factor-2	Adaptor_Signaling_Protein	TNF Receptor-Associated Factor 2|TRAF2	TRAF2 is a homo- or (with TRAF1) heterodimer adaptor protein for TNFR1, TNFR2, and CD40 that mediates activation of NFKB.  TRAF2 contains a TRAF motif known to bind kinases involved in TRAF-mediated signaling, a Zn RING finger, and cysteine/histidine-rich motifs.  E2F1 can down regulate TRAF2 and inhibit anti-apoptotic NFKB signals.  (from OMIM 601895 and NCI)
C17813	Orphan_Nuclear_Receptor-EAR2	Nuclear_Hormone_Receptor_Superfamily	Nuclear Receptor Subfamily 2, Group F, Member 6|EAR2 Protein|ERBAL2 Protein|NR2F6|Orphan Nuclear Receptor EAR-2|v-ERBA Related Protein EAR-2	EAR2 protein is an ERBA-related protein similar in primary structure to the receptors for steroid hormones and thyroid hormone.  EAR2 is highly expressed in the fetal liver.  (from OMIM 132880 and NCI)
C17814	Elongin_Binding_Protein	Transcription_Factor	Elongin Binding Protein|G7 Protein|VHL|VHL Protein|von Hippel Lindau Tumor Supressor Protein	A product of the von Hippel Lindau tumor suppressor gene, Elongin Binding Protein (VHL) is a general transcription elongation factor that increases the rate at which RNA polymerase II transcribes DNA by suppressing polymerase pausing.  VHL is part of a complex (VCB) that includes elongin B, elongin C, and cullin-2, proteins associated with transcriptional elongation and ubiquitination.  VHL directly interacts with, and inhibits, SP1.  VHL inhibits expression of hypoxia-inducing VEGF and GLUT1 genes.  (from OMIM 193300 and NCI)
C17815	BRCA1_Protein	Regulatory_Protein	BRCA1 Protein|BRCA1|Breast Cancer 1, Early Onset Protein|Breast Cancer Type 1 Susceptibility Protein|Breast-Ovarian Cancer Protein	BRCA1, which functions as a tumor suppressor in human breast cancer cells, is a nuclear phosphoprotein which associates with RNA polymerase II holoenzyme. Mutations in BRCA1 are predicted to be responsible for approximately 45% of inherited breast cancer and more than 80% of inherited breast and ovarian cancer. BRCA1 may function as a transcriptional regulator, due to an amino terminal DNA-binding ring finger motif, nuclear localization signals, and an acidic carboxy terminal domain. BRCA1 is also a granin-like protein that functions as a secreted growth inhibitory protein. BRCA1 may normally serve as a negative regulator of mammary epithelial cell growth. This function is compromised in breast cancer either by direct mutation or by alterations in gene expression. BRCA1 participates in transcription-coupled repair of oxidative DNA damage. (LocusLink)
C17816	Dermatologist	Medical_Occupation	Dermatologist|dermatologist	(der-ma-TAH-lo-jist) A doctor who specializes in the diagnosis and treatment of skin problems.
C17817	Endocrinologist	Medical_Occupation	Endocrinologist|endocrinologist	(en-do-krih-NAH-lo-jist) A doctor who specializes in diagnosing and treating hormone disorders.
C17818	Gastroenterologist	Medical_Occupation	Gastroenterologist|gastroenterologist	(GAS-tro-en-ter-AHL-o-jist) A doctor who specializes in diagnosing and treating disorders of the digestive system.
C17819	Experimental_Hematology	Hematology	Experimental Hematology
C17820	Cell_Tissue_Histochemistry	Histological_Techniques	Cell/Tissue, Histochemistry	The study of cells and tissues using chemical staining techniques.
C17821	Oncologist	Medical_Occupation	Oncologist|oncologist	(on-KOL-o-jist) A doctor who specializes in treating cancer.  Some oncologists specialize in a particular type of cancer treatment.  For example, a radiation oncologist specializes in treating cancer with radiation.
C17822	Ophthalmologist	Medical_Occupation	Ophthalmologist
C17823	Otolaryngologist	Medical_Occupation	Otolaryngologist|ENT|otolaryngologist	(OAT-oh-LAR-in-GOL-uh-jist) A doctor who specializes in treating diseases of the ear, nose, and throat.
C17824	Radiologist	Medical_Occupation	Radiologist|RDST|radiologist	(RAY-dee-OL-o-jist) A doctor who specializes in creating and interpreting pictures of areas inside the body. The pictures are produced with x-rays, sound waves, or other types of energy.
C17825	Oral_Surgeon	Surgeon	Oral Surgeon|oral surgeon	A dentist with special training in surgery of the mouth and jaw.
C17826	Urologist	Medical_Occupation	Urologist|urologist	(yoo-RAHL-o-jist) A doctor who specializes in diseases of the urinary organs in females and the urinary and sex organs in males.
C17827	Information_Resources_Management	Information_Sciences	Information Resources Management	Cataloging, grouping, and flagging data for ready retrieval
C17828	Biological_Process	root_node	Biological Process|Biological Function	An activity that occurs between organisms or that occurs within an organism and involves the function, or modification of function by external factors, of biologic molecules, biologic complexes, subcellular components, cells, tissues, organs, or organ systems.
C17829	Gynecologic_Oncology	Oncology	Gynecologic Oncology|oncology, gynecologic	The medical specialty that focuses on tumors of the reproductive tract of women.
C17830	Gynecologic_Oncologist	Oncologist	Gynecologic Oncologist|gynecologic oncologist	(guy-neh-ko-LAH-jik on-KOL-o-jist) A doctor who specializes in treating cancers of the female reproductive organs.
C17831	Hematologist	Medical_Occupation	Hematologist|hematologist	(hee-ma-TOL-o-jist) A doctor who specializes in treating diseases of the blood.
C17832	Internist	Medical_Occupation	Internist	A specialist in internal medicine
C17833	Radiation_Oncologist	Oncologist	Radiation Oncologist|oncologist, radiation|radiation oncologist	(ray-dee-AY-shun on-KOL-o-jist) A doctor who specializes in using radiation to treat cancer.
C17834	Radiation_Therapist	Medical_Occupation	Radiation Therapist|Radiotherapist|radiation therapist|therapist, radiation	A health professional who gives radiation treatment.
C17835	Eye_Surgeon	Surgeon	Eye Surgeon|surgeon, eye
C17836	Thoracic_Surgeon	Surgeon	Thoracic Surgeon|Chest Surgeon|surgeon, chest|surgeon, thoracic
C17837	Oncology	Internal_Medicine	Oncology|Cancer, Oncology|oncology	The study of cancer.
C17838	Medical_Oncologist	Oncologist	Medical Oncologist|medical oncologist|oncologist, medical	(on-KOL-o-jist) A doctor who specializes in diagnosing and treating cancer using chemotherapy, hormonal therapy, and biological therapy. A medical oncologist often is the main caretaker of someone who has cancer and coordinates treatment provided by other specialists.
C17839	Surgical_Oncology	Oncology	Surgical Oncology|oncologic surgery|oncology, surgical	Intervention studies in which surgery is the dominant feature to prevent, diagnose, stage, or treat cancer (except neurosurgery and eye surgery).  Includes special devices for dividing or destroying tissues, development and improvement of instruments for detection and diagnosis of tumors where surgery/biopsy is the dominant feature, cytoreductive procedures, intraoperative radiotherapy, surgical treatment of cancer and its complications, surgical supportive care, and plastic reconstructive and rehabilitation surgery.
C17840	Surgical_Oncologist	Oncologist	Surgical Oncologist|Oncologist, Surgical|surgical oncologist	A doctor who performs biopsies and other surgical procedures in cancer patients.
C17841	Oncologic_Surgeon	Surgeon	Oncologic Surgeon|surgeon, oncologic
C17842	Urologic_Surgeon	Surgeon	Urologic Surgeon|surgeon, urologic
C17843	Epidemiologist	Miscellaneous_Occupations	Epidemiologist
C17844	Pediatric_Hematology_Oncology	Pediatrics	Pediatric Hematology/Oncology|hematology/oncology, pediatric|oncology/hematology, pediatric|pediatric hematology oncology|pediatric oncology/hematology
C17845	Hematologist_Oncologist_Pediatric	Pediatric_Hematology_Oncology	Hematologist/Oncologist, Pediatric|oncologist/hematologist, pediatric|pediatric hematologist/oncologist
C17846	Performance_Status_2	Zubrod_Performance_Status	Performance Status 2|Karnofsky 60-70|Zubrod Performance Status 2	Ambulatory and capable of all self-care but unable to carry out any work activities. Up and about more than 50% of waking hours (Eastern Cooperative Oncology Group)
C17847	Performance_Status_3	Zubrod_Performance_Status	Performance Status 3|Karnofsky 40-50|Zubrod Performance Status 3	Capable of only limited self-care, confined to bed or chair more than 50% of waking hours. (Eastern Cooperative Oncology Group)
C17848	Performance_Status_4	Zubrod_Performance_Status	Performance Status 4|Karnofsky 20-30|Zubrod Performance Status 4	Completely disabled. Cannot carry on any self-care. Totally confined to bed or chair (Eastern Cooperative Oncology Group)
C17849	History_of_Myocardial_Infarction_Within_6_Months	Personal_Attribute	History of Myocardial Infarction Within 6 Months
C17850	Head_and_Neck_Surgeon	Surgeon	Head and Neck Surgeon
C17851	Pediatric_Surgery	Surgical_Specialty	Pediatric Surgery
C17852	Pediatric_Oncology	Oncology	Pediatric Oncology|Oncology, Pediatric	The medical specialty that focuses on tumors in children.
C17853	Pediatric_Oncologist	Oncologist	Pediatric Oncologist	Oncologists who specialize in treating children
C17854	Neurologic_Oncology	Oncology	Neurologic Oncology|oncology, neurologic
C17855	Pediatric_Neurology	Pediatrics	Pediatric Neurology|neurology, pediatric
C17856	Dermatologic_Oncology	Oncology	Dermatologic Oncology|oncology, dermatologic
C17857	Plastic_Surgeon	Surgeon	Plastic Surgeon|plastic surgeon	A surgeon who specializes in reducing scarring or disfigurement that may occur as a result of accidents, birth defects, or treatment for diseases.
C17858	Pediatric_Neurology_Oncology	Pediatrics	Pediatric Neurology/Oncology|neurology/oncology, pediatric|oncology/neurology, pediatric|pediatric neurology oncology|pediatric oncology/neurology
C17859	Pediatric_Neurologist_Oncologist	Pediatric_Oncologist	Pediatric Neurologist/Oncologist|Neurologist/Oncologist, Pediatric|Oncologist/Neurologist, Pediatric
C17860	Colon_and_Rectal_Surgeon	Surgeon	Colon and Rectal Surgeon
C17861	Pediatric_Radiology	Radiology	Pediatric Radiology|radiology, pediatric
C17862	Pediatric_Radiologist	Radiologist	Pediatric Radiologist|radiologist, pediatric
C17863	Endocrinology_and_Metabolism	Retired_Concepts	Endocrinology and Metabolism|Metabolism and Endocrinology
C17864	Hematology_Board_Certification	Board_Certification	Hematology Board Certification|Board Certification, Hematology
C17865	Medical_Oncology_Board_Certification	Board_Certification	Medical Oncology Board Certification|board certification, medical oncology
C17866	Gynecologic_Oncology_Board_Certification	Medical_Oncology_Board_Certification	Gynecologic Oncology Board Certification|board certification, gynecologic oncology
C17867	Therapeutic_Radiology_Board_Certification	Board_Certification	Therapeutic Radiology Board Certification|board certification, therapeutic radiology
C17868	Pediatric_Hematology-Oncology_Board_Certification	Board_Certification	Pediatric Hematology-Oncology Board Certification|board certification, pediatric hematology-oncology
C17869	Assessment_of_Gonadal_Function	Test|Test_Generic	Assessment of Gonadal Function	Tests to assess the function of testes and ovaries, frequently a part of fertility assessment.
C17870	Metabolic_Abnormality_Assessment	Healthcare_Activity	Metabolic Abnormality Assessment|Abnormal Assessment of Metabolism|Metabolic Assessment, Abnormality|Metabolic Studies|Metabolism Studies
C17873	Psychosocial_Effects_Treatment	Effect	Psychosocial Effect|Effects, Psychosocial|Psychosocial Effects|Psychosocial Effects/Treatment|Treatment/Psychosocial Effects	Having to do with the physical, psychological, cognitive, and social consequences of disease, including stigmatization of persons affected.
C17874	Educational_Intervention	Patient_or_Public_Education	Educational Intervention|Education for Intervention|intervention, educational
C17876	Methotrexate-E_Therapeutic_Implant	Methotrexate	Methotrexate-E Therapeutic Implant|MTX-e TI|MTX/epi gel|Methotrexate-epinephrine therapeutic implant|Methotrexate/epi
C17877	Fluorouracil-E_Therapeutic_Implant	Fluorouracil	Fluorouracil-E Therapeutic Implant|5-FU-e TI|5-FU/epi gel|5-Fluorouracil/epi|Fluorouracil-epinephrine therapeutic implant|Fluorouracil/epi
C17878	Melan-A	Retired_Concepts	Melan-A|Antigen LB39-AA|Antigen SK29-AA|MART-1|MART-1 Antigen|MART-1 Tumor Antigen|MART1|MLANA|MLANA Protein|Melan A|Melan-A Protein|Melanoma Antigen Recognized by T Cells 1|Melanoma Antigen Recognized by T-Cells 1	MART-1 (Melanoma Antigen Recognized by T cells, also called Melan-A) is a self antigen expressed on melanocytes and the retina.  It is an 18kDa melanocyte differentiation antigen.  It is also expressed on the surface of most melanomas.
C17879	Cisplatin-E_Therapeutic_Implant	Cisplatin	Cisplatin-E Therapeutic Implant|CDDP-e therapeutic implant|CDDP/epi|CDDP/epi gel|CEG|Cisplatin-Epinephrine|Cisplatin/Epinephrine Gel|Intradose|Intradose MPI-5010|MP 5010 TI|MP 5010 Therapeutic Implant|MPI 5010
C17881	Federated_States_of_Micronesia	Country	Federated States of Micronesia|583|FM|FSM	An island group in the North Pacific Ocean, about three-quarters of the way from Hawaii to Indonesia. (CIA World Factbook 2002)
C17882	Northern_Mariana_Islands	Country	Northern Mariana Islands|580|CQ|MNP|MP	A country in the Pacific, comprising islands in the North Pacific Ocean, about three-quarters of the way from Hawaii to the Philippines. (CIA World Factbook 2002)
C17883	Palliative_Surgery	Surgery	Palliative Surgery	Surgery that does not alter the course of a disease, but improves the quality of life.
C17884	Aruba	Country	Aruba|533|AA|ABW|AW	Island in the Caribbean Sea, north of Venezuela. (CIA World Factbook 2002)
C17885	Saint_Kitts_and_Nevis	Country	Saint Kitts and Nevis|659|KN|KNA|SC	Islands in the Caribbean Sea, about one-third of the way from Puerto Rico to Trinidad and Tobago. (CIA World Factbook 2002)
C17886	Meta-Analysis	Statistical_Methods	Meta-Analysis	Meta-analysis is a set of statistical procedures designed to accumulate experimental and correlational results across independent studies that address a related set of research questions.
C17887	Cultural_Diversity	Social_Concepts	Cultural Diversity	The inevitable variety in customs, attitudes, practices, and behaviors that exists among groups of individuals from different ethnic, racial, or national backgrounds who come into contact.
C17888	Heat-Shock_Response	Cellular_Stress_Response	Heat-Shock Response|Heat Shock	A constellation of responses that occur when an organism is exposed to excessive heat and other environmental stresses. Responses include synthesis of some proteins, repression of other proteins, and expression of new proteins. (From Segen, Dictionary of Modern Medicine, 1992)
C17889	Mucosal_Immunity	Immunity	Mucosal Immunity	Immunoglobuling A secretion by mucosal epithelia in the gastrointestinal, respiratory, and genitourinary tracts. Mucosal immunity promotes resistance toward bacteria, viruses, and parasites in these ports of entry into the body.
C17890	DNA_Footprinting	Molecular_Biology_Techniques	DNA Footprinting	A procedure in which multilocus band patterns of a DNA sample are generated by digestion of the DNA with restriction enzymes followed by electrophoresis and visualization by hybridization with probes specific for repetitive sequences. In forensic medicine, the probes used are "core" sequences specific for simple tandem-repetitive sequences (MINISATELLITE REPEATS or VNTRs). The multilocus band patterns, known as DNA fingerprints, are evaluated for similarities with DNA from an individual (From MSH 2001).
C17891	CD56_Antigen	Retired_Concepts	CD56 Antigen|CD56|NCAM|NKH-1|Neural Cell Adhesion Molecule	Neural Cell Adhesion Molecule is a membrane-bound glycoprotein member of the Ig superfamily that binds to a variety of other cell adhesion proteins involved in diverse contact-mediated interactions.  NCAM appears on early embryonic cells and is important in the formation of cell collectives at sites of morphogenesis.  Later it is found on differentiated neurons, astrocytes, oligodendrocytes, and myotubes and mediates neuronal adhesion, guidance, and differentiation.  NCAM plays a role in cell-cell and cell-matrix adhesion through homophilic and heterophilic binding.  The invertebrate cell adhesion molecules fasciclin II (grasshoppers and Drosophila) and apCAM (Aplysia) are related to NCAM and can mediate homophilic cell aggregation.  Four main isoforms exist, including CD56, but many variants result from alternative splicing and post-translational modifications.  (from OMIM 116930 and NCI)
C17892	Imaging_Phantoms	Imaging_Device	Imaging Phantoms|Phantoms	Imaging Phantoms are used for the assessment of image quality.  Within these functional categories phantoms can be further defined.  (1) Body Phantoms: have the shape and composition of the human body or part of it.  They are also referred to as anthropomorphic phantoms.  (2) Phantoms that are used for standardization and inter-comparison of various radiation conditions are often referred to as Standards.  (3) Reference Phantoms include phantoms used to derive radiation dose calculations, mineral density equivalences or other similar type measurements.  They can further be defined by their intended modality such as Ultrasound, Mammography, Computed Tomography (CT), etc.
C17893	SRC_Family_Tyrosine_Kinase	Protein_Tyrosine_Kinase	SRC Family Tyrosine Kinase	Family of non-receptor protein-tyrosine kinases homologous to src. They are closely related intracellular enzymes that participate in signal transduction pathways in a variety of hemopoietic cells and especially their surface receptors. EC 2.7.1.-.
C17894	Cell_Respiration	Energy_Metabolism	Cell Respiration|aerobic metabolism|aerobic respiration|cell respiration|oxidative metabolism	A chemical process in which oxygen is used to make energy from carbohydrates (sugars).
C17895	Cell_Lineage	Cell_Differentiation	Cell Lineage	Cells that are ancestral predecessors of progenitor cells. This process envelopes the entire developmental history of the cells as traced from the first mitotic division of the original cell or cells.
C17896	HT-29	Tumor_Cell_Line	HT-29|HT29 Cells
C17897	Selectin	Cell_Adhesion_Molecule	Selectin	A family of cell adhesion molecules containing a lectin-like domain, an EGF-like domain, and domains homologous to complement-binding proteins.  Selectins mediate leukocyte binding to the vascular endothelium.
C17898	Blocking_Antibody	Antibody	Blocking Antibody	An antibody that prevents some reaction from taking place, for example one antibody competing with another for a cell surface receptor. (from On-line Medical Dictionary)
C17899	p59-HCK	SRC_Family_Tyrosine_Kinase	p59-HCK|HCK|Hemopoietic Cell Kinase p59	Encoded by the HCK proto-oncogene, HCK appears to be a SRC-family tyrosine kinase, expressed primarily in hematopoietic cells, especially of myeloid lineage and particularly in mature granulocytes and monocytes.  HCK deletions may contribute to some acute myeloid leukemias and myeloproliferative disorders.  (from OMIM 142370 and NCI)
C17900	CCAAT_Enhancer_Binding_Protein_Epsilon	CCAAT_Enhancer_Binding_Protein	CCAAT/Enhancer Binding Protein Epsilon|C/EBP Epsilon|CEBPE	C/EBP epsilon is a CCAAT enhancer-binding protein and bZIP transcription factor uniquely expressed in, and essential for differentiation of, granulocytic progenitor cells.  C/EBP epsilon forms homo- or heterodimers with other family members and expression is enhanced by retinoids.  Four isoforms are expressed from different promoters and an alternate start codon.  (from OMIM 600749 and NCI)
C17901	Cyclin-Dependent_Kinase_Inhibitor-1B	Cyclin-Dependent_Kinase_Inhibitor	Cyclin-Dependent Kinase Inhibitor 1B|CDKN1B|Cyclin-Dependent Kinase Inhibitor p27|p27-Kip1|p27Kip1	Involved in G1 arrest, nuclear CDKN1B inhibits bound cyclin/CDK complexes and negatively regulates cell cycle progression. CDKN1B, a CASP-3 apoptotic target, is phosphorylated by CCNE1/CDK2, ubiquitinated by SKP2, and degraded.  CDKN1B expression is regulated by PI3K/PKB and RAS/RAL regulated AFX-like forkhead proteins.  Immunohistochemical detection of p27Kip1 may help to identify patients with gastric carcinomas, without lymph node involvement, who are at high risk of death.  Low CDKN1B expression is strongly associated with a with poor prognosis.  (from Int J Oncol 2001. 18:151, Cancer 2000. 89:2247, SWISS-PROT P46527, OMIM 600778, and NCI)
C17902	Furin_Preproprotein	Protease	Furin Preproprotein|FURIN|PACE Protein|Paired Basic Amino Acid Cleaving Enzyme	Paired basic amino acid cleaving enzyme is an ubiquitous proprotein endoprotease that functions within secretory pathways and is localized in the trans Golgi network.  PACE cleaves protein substrates at RX(K/R)R consensus motifs and plays a significant role in tumor progression.  (from OMIM 136950 and NCI)
C17903	NF-AT	Protein_or_Riboprotein_Complex	NF-AT|NFAT-1|Nuclear Factor of Activated T-cells	NFAT is a multi-subunit transcription complex that includes homo- or hetero-dimers of FOS and JUN proteins.  NFATC, the Dorsal/Rel family cytosolic component of NFAT, is translocated to the nucleus following TCR-induced PKC stimulation and calmodulin-dependent calcineurin-mediated dephosphorylation.  Phosphoprotein NFATP, the 'preexisting component' of NFAT present in the unstimulated T-cell cytosol, locates in the nucleus as part of NFAT after activation.
C17904	Ewing_Sarcoma_Breakpoint_Region-1_Protein	RNA_Binding_Protein	Ewing Sarcoma Breakpoint Region 1 Protein|EWS Protein|EWSR1|EWSR1 Protein|RNA Binding Protein EWS	Ubiquitous nuclear and cytoplasmic RNA Binding Protein EWS belongs to the TET family of RNP proteins, contains an RNA recognition motif and a RANBP2-type zinc finger, and may function as a repressor.  EWS contains a transcription activation domain, but the RNA-binding domain can repress trans-activation by the activation domain.  The RNA-binding activity is localized to a C-terminal RGG box.  EWS binds RNA, calmodulin, and the RNA polymerase II 33 kD polypeptide (RPB3), but not RPB5 or RPB7.  EWS interacts with FAK2 and relocates from cytoplasm to ribosomes upon FAK2 activation.  Two isoforms of the EWS protein are produced by differential splicing.  (from SWISS-PROT Q01844 and NCI)
C17905	ELK3_Protein	ETS_Family_Protein	ELK3 Protein|ELK3|ELK3, ETS-Domain Protein|ETS-Domain Protein|ETS-Domain Protein ELK-3|ETS-Related Protein|ETS-Related Protein ERP|ETS-Related Protein NET|SAP-2|SAP2 Protein|SRF Accessory Protein 2	ELK3 Protein, an ELK subfamily member of ETS-related DNA-binding transcription factors, is highly expressed at early stages of B-lymphocyte development, declining upon cell maturation.  ELK3 may play a role in B-cell development and Ig gene regulation.  (from OMIM 600247 and NCI)
C17906	BHLH_Protein	DNA_Binding_Protein	BHLH Protein|Basic HLH Protein|Basic Helix-Loop-Helix Protein|bHLH Protein	Term used to denote the class of sequence-specific DNA-binding proteins that contain the bHLH domain.
C17907	TRADD_Protein	Adaptor_Signaling_Protein	TRADD Protein|TNF Receptor-Associated Protein with a Death Domain|TNFR1-Associated Death Domain Protein|TNFRSF1A-Associated via Death Domain|TRADD	TRADD is an adaptor protein involved in the recruitment of FADD or TRAF signaling proteins into TNF-stimulated cell death or NFKB induction.  TRADD contains a death domain, similar to that of TNFR1, capable of mediating TRADD oligomerization, interaction with the TNFR1 death domain, stimulation of apoptosis, and NFKB activation.  TNF-induced apoptosis involves TRADD-mediated ICE cysteine protease activation.  NFKB activation by TRADD involves a different pathway.  (from J Leukoc Biol 1998. 63:678, OMIM 603500, and NCI)
C17908	DCC_Protein	Protein_with_Unknown_or_Unclassified_Function	DCC Protein|CRC18|DCC|Deleted in Colorectal Carcinoma Protein	Isolated as a gene in a region frequently deleted in colorectal carcinomas, the DCC gene encodes DCC Protein, which has sequence similarity to cell adhesion molecules such as N-CAM and may participate with other proteins in cell-cell and cell-matrix interactions. It is a transmembrane protein of the immunoglobulin superfamily, is expressed on spinal commissural axons and possesses netrin-1-binding activity. Knockout studies in mice failed to support a tumor-suppressor function for DCC in the mouse, but were consistent with the hypothesis that DCC is a component of the receptor for netrin-1, a neuronal chemoattractant. (from OMIM)
C17909	Tissue_Polypeptide_Specific_Antigen	Protein_or_Riboprotein_Complex	Tissue Polypeptide Specific Antigen|K8/K18|Keratin 8/Keratin 18|TPS	An antigenic dimeric combination of intermediate filament Keratin 8 and Keratin 18 peptides, K8/K18, which is detectable in serum and is being investigated as a cancer marker.
C17910	Angiostatin	Angiogenesis_Inhibitory_Protein	Angiostatin|Kringles 1-4 of Plasminogen|PLG	Encoded by human PLG Gene (Plasminogen Family) and expressed in the kidney, angiostatin is an angiogenesis inhibitor present in plasma and other extracellular fluids that blocks neovascularization and mediates suppression of metastases. Containing at least three kringles, angiostatin is a 38-kD internal (serine protease) proteolytic fragment of plasminogen.
C17911	Polo-Like_Kinase	Serine-Threonine_Protein_Kinase	Polo-Like Kinase|PLK	Polo-like kinase is a serine/threonine protein kinase involved in mitosis and required for spermatogenesis.  By phosphorylation of the cyclin B1 nuclear export signal, PLK1 may target mitosis-promoting factor to the nucleus during prophase, which is essential for induction and coordination of M-phase.  Localized to centrosomes, centromeres/kinetochores, and the spindle midzone, PLK may regulate organization and function of the mitotic apparatus.  (from OMIM 602098 and NCI)
C17912	Tumor_Protein_p53-Binding_Protein-2	Ligand_Binding_Protein	Tumor Protein p53 Binding Protein 2|BCL-2 Binding Protein|TP53BP2|p53-Binding Protein 2	Found only in the cytosol, TP53BP2 impedes cell cycle progression beyond G2/M.  It enhances p53 trans-activation function and induces p21 (CDKN1A) expression.  TP53BP2 contains ankyrin repeats and an SH3 domain, required for interaction with p53 and BCL2; TP53BP2 cannot bind both proteins simultaneously.  (from OMIM 602143 and NCI)
C17913	Tuberin	Signaling_Protein	Tuberin|TSC2|Tuberous Sclerosis 2 Protein	Tuberin has sequence similarity to the GTPase-activating protein GAP3 and may regulate cell growth.  It specifically stimulates the GTPase activity of RAS-related RAP1A protein, but not of RAP2, H, RAC, or RHO.  Tuberin exhibits GAP activity (mediated by rabaptin-5) towards RAB5, a critical docking and fusion component of the endocytic pathway.  (from OMIM 191092 and NCI)
C17914	RecQL_Helicase	RecQ_Helicase_Family_Protein	RecQL Helicase|RECQL	RecQL protein is a 13,3 kD peptide (1208 aa), belongs to the RecQ subfamily of helicases and contains from aa 476 to 824 an helicase domain with a potential ATP binding site from aa 502 to 509, and the DEAH box from aa 605 to 608.  The expression of RecQ4 gene is partially upregulated in the G1/S phase of cell cycle. It suppresses promiscuous genetic recombination and ensures accurate chromosome segregation.
C17915	hSNF5-INI1_Protein	Protein_Complex_Subunit	hSNF5/INI1Protein|BAF47|INI1|Ini1/hSNF5|Integrase Interactor 1|Integrase Interactor 1 Protein|Malignant Rhabdoid Tumor Suppressor|SMARCB1|SNF5|SNF5 Homolog|SWI/SNF Related Matrix Associated Actin Dependent Regulator of Chromatin Subfamily B Member 1|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily B, Member 1|Snf5p|Sucrose Nonfermenting 5|hSNF5	Product of the SMARCB1 gene, hSNF5/INI1 protein is a member of the multi-protein SWI/SNF chromatin-remodeling complex that opens chromatin to facilitate target access by the transcription machinery.  Two isoforms of hSNF5/INI1 are produced by alternative splicing.  (from OMIM 601607 and NCI)
C17916	BRCA2_Protein	Regulatory_Protein	BRCA2 Protein|BRCA2|Breast Cancer 2, Early Onset Protein|Breast Cancer Type 2 Susceptibility Protein|FANCB|FANCD1	BRCA2 putatively functions as a tumor suppressor gene, however, its exact function has not been well characterized. The similarity of, and functional analysis of, BRCA2 and BRCA1 proteins, suggests that these proteins function in the same genetic pathway. BRCA1 and BRCA2 have transcriptional activation potential and the two proteins are associated with the activation of double-strand break repair and/or homologous recombination. The two proteins have been shown to coexist and colocalize in a biochemical complex. (from LocusLink)
C17917	Eukaryotic_Translation_Initiation_Factor_3_Subunit-6	Protein_Complex_Subunit	Eukaryotic Translation Initiation Factor 3, Subunit 6|EIF-3 P48|EIF3-p48|EIF3S6|Eukaryotic Translation Initiation Factor 3 Subunit 6|Eukaryotic Translation Initiation Factor 3, 48-kD|Eukaryotic Translation Initiation Factor 3, Subunit 6 (48kd)|Mammary Tumor-Associated Protein INT-6|Viral Integration Site Protein INT-6|eIF3e	Eukaryotic initiation factor-3 (eIF3) is the largest of the eIFs and consists of at least ten non-identical subunits in mammals.  eIF3S6 (p48) appears to interact with eIF3-p170.  eIF3S6 binds to the 40S ribosome and promotes the binding of methionyl-tRNAi and mRNA.  Cytoplasmic eIF3 is ubiquitously expressed.  (from Swiss-Prot Q64252 and NCI)
C17918	Zinc_Finger_Protein-145	Transcription_Repressor_Corepressor	Zinc Finger Protein 145|PLZF|Promyelocytic Leukemia Zinc Finger Protein	Expressed in early myeloid cells, peripheral mononuclear cells, and in ovary, kidney, and lung by retinoic acid induced human ZNF145 Gene (Krueppel Family), alternative isoforms PLZFA (550-aa) and PLZFB (673-aa, 74-kDa) of nuclear Zinc Finger Protein 145 are probable transcription factors containing a BTB/POZ domain. Conserved N-terminal protein interaction BTB/POZ domains of some C2H2 transcription factors interact with components of histone deacetylase complex and repress transcription. ZNF145 may play a role in myeloid maturation and development, or maintenance of differentiated tissues. A growth-inhibitory and pro-apoptotic factor in limb bud formation, ZNF145 is an axial and appendicular skeletal anterior/posterior patterning mediator that regulates HOX gene expression. APL associated translocation t(11;17)(q32;q21) involves ZNF145 and RARA. (NCI)
C17919	WNT7A_Protein	WNT_Family_Protein	WNT7A Protein|WNT7A	Human WNT7A protein is an homologue of the Drosophila wingless segment polarity gene product.  WNT7A is a cysteine-rich extracellular matrix intercellular signaling glycoprotein implicated in the regulation of cell fate and patterning during embryogenesis.  Gene expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.  WNT7A guides development of the female reproductive tract and controls limb development at the dorsoventral axis.  (from OMIM 601570 and NCI)
C17920	CD166_Antigen	Cell_Adhesion_Molecule	CD166 Antigen|ALCAM|Activated Leukocyte Cell Adhesion Molecule|BEN|CD6 Ligand|Neurolin	ALCAM is a cell adhesion molecule expressed on mitogen-activated leukocytes and monocytes, fibroblasts, neurons, and tumor-derived cell lines but not on unactivated leukocytes.  ALCAM is a ligand for CD6, a receptor expressed on T-cells involved in cell adhesion interactions between thymocytes and thymic epithelial cells.  ALCAM/CD6 interactions may play a role in the binding of T- and B-cells to activated leukocytes.  ALCAM has five Ig domains and its amino acid sequence has significant homology to chicken neural adhesion molecule BEN/SC-1/DM-GRASP.  (from OMIM 601662 and NCI)
C17921	VAV2_Protein	Guanine_Nucleotide_Exchange_Factor	VAV2 Protein|VAV2|VAV2 Gene Product	A member of the VAV oncogene family, VAV2 is a probable exchange factor for a RAS-like GTP-binding protein and responds to a cell surface receptor tyrosine kinase.  Integrin-induced phosphorylation of VAV2 requires SYK.  VAV2 contains a calponin-homology domain, a DBL-homology domain, a PH domain, a DAG binding domain, an SH2 domain, and SH3 domains.  (from OMIM 600428 and NCI)
C17922	Somatostatin_Receptor-2	Somatostatin_Receptor	Somatostatin Receptor 2|SSTR2	Somatostatin binds to a group of structurally related tissue-specific high-affinity integral membrane GPCRs (family 1), coupled via G proteins to inhibition of adenylyl cyclase.  Somatostatin Receptor 2 is expressed highest in the cerebrum and kidney and inhibits DNA synthesis and cell proliferation.  SSTR2 appears to antagonize SSTR5, and vice versa, suggesting a tissue-specific function and interaction between these receptors.  SSTR2 stimulates phosphotyrosine phosphatase and PLC via G proteins.  It also appears to suppress voltage dependent calcium-channels.  Two isoforms are produced by alternative splicing.  (from OMIM 182452, SWISS-PROT P30874, and NCI)
C17923	Receptor-Interacting_Serine-Threonine_Kinase-1	Serine-Threonine_Protein_Kinase	Receptor-Interacting Serine/Threonine Kinase 1|RIP|RIP Protein Kinase|RIPK1|Receptor-Interacting Protein	A 74 kDa serine/threonine kinase originally identified by its ability to associate with Fas/APO-1 and induce cell death.  RIP interacts with the cytoplasmic domain of FAS, and with TNFR1 through the adaptor proteins TRADD and TRAFs 1, 2, and 3.
C17924	Ataxia_Telangiectasia_Mutated_Protein	Serine-Threonine_Protein_Kinase	Ataxia Telangiectasia Mutated Protein|AT Mutated|ATM|ATM Protein|ATM Serine/Threonine Protein Kinase|Ataxia Telangiectasia Mutated|Ataxia Telangiectasia Protein	Ataxia Telangiectasia Mutated Protein, encoded by the ATM gene, belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates and functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, which results in a defect in cell cycle regulation and DNA repair. Mutations are also associated with sensitivity to DNA damaging agents such as ionizing radiation. At least 3 alternatively spliced transcript variants encoding distinct isoforms, have been identified. (from LocusLink)
C17926	Interferon_Regulatory_Factor-4	Transcription_Factor	Interferon Regulatory Factor 4|IRF4|IRF4 Protein|ISRE DNA Binding Protein|Interferon Stimulated Response Element DNA Binding Protein|LSIRF Protein|Lymphocyte-Specific IRF	Interferon regulatory factor 4 is a transcriptional activator that binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter and to the immunoglobulin lambda light chain enhancer, together with PU.1.  IRF4 probably plays a role in the ISRE-targeted signal transduction mechanisms of lymphoid cells.  Two isoforms are produced by alternative splicing.  (from OMIM 601900 and NCI)
C17927	Somatostatin_Receptor-5	Somatostatin_Receptor	Somatostatin Receptor 5|SSTR5	Somatostatin binds to a group of structurally related tissue-specific high-affinity integral membrane GPCRs (family 1), coupled via G proteins to inhibition of adenylyl cyclase.  The Somatostatin Receptor 5 and D2R GPCRs interact to create a novel receptor with enhanced activity; either ligand promotes heterodimerization.  SSTR5 increases DNA synthesis, whereas SSTR2 inhibits DNA synthesis and cell proliferation.  SSTR2 appears to antagonize SSTR5, and vice versa, suggesting a tissue-specific function and interaction between these receptors.  SSTR5 is expressed in adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus.  (from OMIM 182455, SWISS-PROT P35346, and NCI)
C17928	Centromere_Protein-F	Cell_Cycle_Protein|Nuclear_Matrix_Protein	Centromere Protein F|AH Antigen|CENP-F Kinetochore Protein|CENPF|Cell-Cycle-Dependent 350K Nuclear Protein|Mitosin	Mitosin is a nuclear matrix homo- or heterodimeric protein that is associated with kinetochores from the onset of M phase to metaphase, with accumulation mitosin peaking in G2/M phase.  It is rapidly degraded after mitosis.  Mitosin may be involved in chromosome segregation and kinetochore function.  It interacts with RB, CENP-E, and BUBR1.  (from SWISS-PROT P49454, OMIM 600236, and NCI)
C17929	RIP140_Protein	Transcription_Coactivator	RIP140 Protein|NRIP1|NRIP1 Protein|Nuclear Receptor Interacting Protein 1|RIP140|Receptor Interacting Protein 140|Receptor Interacting Protein, 140 kDa	NRIP1 associates directly with a transcriptional activation domain of ESR in the presence of estrogen and modulates transcriptional activation by the receptor. (from OMIM 602490, Swiss-Prot P48552, and NCI)
C17930	Immune_Response	Immune_Function	Immune Response|immune response	1. any response of the immune system to an antigen including antibody production and/or cell-mediated immunity; 2. the response of the immune system to an antigen (immunogen) that leads to the condition of induced sensitivity; the immune response to the initial antigenic exposure (primary immune response) is detectable, as a rule, only after a lag period of from several days to two weeks; the immune response to a subsequent stimulus (secondary immune response) by the same antigen is more rapid than in the case of the primary immune response.
C17931	Antibody-Mediated_Lympholysis	Antibody-Dependent_Cellular_Cytotoxicity	Antibody-Mediated Lympholysis	The cytotoxicity of cells depending on antibody recognition.  The killing of a target cell by a killer cell by means of an antibody directed to the target by the antigen-binding arms and anchored to the killer cell via an Fc receptor.
C17932	Angiogenesis	Histogenesis	Angiogenesis|angiogenesis	(an-gee-o-GEN-eh-sis) Blood vessel formation. Tumor angiogenesis is the growth of blood vessels from surrounding tissue to a solid tumor. This is caused by the release of chemicals by the tumor.
C17933	Carbohydrate_Metabolism	Intermediary_Metabolism	Carbohydrate Metabolism|Metabolism, Carbohydrates/Storage/Polysaccharides	Oxidation, breakdown, and synthesis of carbohydrates in the tissues.
C17934	Tobacco_Smoking	Smoking_Behavior	Tobacco Smoking|SMK|Smoking	The act of puffing and/or inhaling smoke from a lit cigarette, cigar, or pipe.
C17935	Therapeutic_Agents	Research_Funding_Categories	Therapeutic Agents	1D1; Basic Sciences Research (includes vaccine and chemotherapy development); Therapeutic Agents (antiviral, antimicrobial, immunomodulating and antineoplastic agents); Development. Physical or chemical agents that may improve the health of a patient by impeding cancer or other diseases
C17936	Quinone_Oxidoreductase	Oxidoreductase	Quinone Oxidoreductase|DT-diaphorase|Diaphorase (NADH/NADPH)|Diaphorase-4|Menadione Reductase|NAD(P)H Dehydrogenase (Quinone) 1|NAD(P)H:Quinone Oxidoreductase|NADPH:Quinone Reductase|NQO1|Phylloquinone Reductase|Zeta-Crystallin	A flavoprotein acting on NADPH and using quinone as acceptor. Inhibited by dicoumarol. [EC 1.6.99.2 created 1961 as EC 1.6.5.2, transferred 1965 to EC 1.6.99.2]. (from IUBMB)
C17937	Immune_Function	Host_Defense_Mechanism	Immune Function|Cellular Immune Function|Immune Function, Cellular	Any multicellular process of immune cells effecting or involved with the immune response or immune maintenance. (NCI)
C17938	Genetic	General_Modifier	Genetic|genetic	Having to do with information that is passed from parents to offspring through genes in sperm and egg cells.
C17939	Genetic_Susceptibility	Susceptibility	Genetic Susceptibility|Inherited Predisposition|Inherited Susceptibility|genetic susceptibility	An inherited increase in the risk of developing a disease.
C17940	Microbial_Genetics	Genetics	Microbial Genetics
C17941	Exposure	Properties_or_Attributes	Exposure|EXPO	The act of subjecting someone or something to an influencing experience.
C17942	Gleason_Score	Retired_Concepts	Gleason Score
C17943	Morphology	Anatomical_Sciences	Morphology|MORPH|morphology	The science of the form and structure of organisms (plants, animals, and other forms of life), or of their parts, and the study or science of the same.  In pathology, the specific appearance of cells and tissues (normal and abnormal) under the light or electron microscope.
C17944	Contracting	Business_Rules	Contracting|Contracting Opportunities	The process by which non-govt. companies obtain and do work for the Federal government
C17945	Atypical_Regeneration	Regeneration	Atypical Regeneration	Atypical Regeneration consists of reactive cellular proliferation, abnormal reproduction, or renewal of cells and tissues that have been damaged or destroyed due injury, morbidity, or ordinary life processes and is characterized by nuclear/cytoplasmic atypia. The concept encompasses size, shape, and organization of cell architecture specific for dysplasia, cancer in situ, inflammatory atypia, and preneoplastic states associated with regenerative changes in tissue.
C17946	Community_Physician	Physician	Community Physician	A medical practitioner whose primary concern is the health status of the population within a defined geographic area, who is usually responsible for assessment and evaluation of the community's health needs and for the organisation of health services to meet those needs. He will generally not render primary health care, except for specific disease entities such as selected communicable diseases. His role varies from country to country, but he is usually employed by a government agency.
C17947	Prosthodontist	Medical_Occupation	Prosthodontist|prosthodontist	(pros-tho-DON-tist) A dentist with special training in making replacements for missing teeth or other structures of the oral cavity to restore an individual's appearance, comfort, or health.
C17948	Therapeutic_Implant	Drug_Delivery_System	Therapeutic Implant|Drug Implant	A device placed in tissue to deliver therapeutic agents at a controlled, constant release rate.
C17949	Cigarette_Smoker	At-Risk_Population	Cigarette Smoker	An individual who currently, or recently, smokes cigarettes regularly.
C17950	Ashkenazi_Jew	Ethnic_Group	Ashkenazi Jew	Ashkenazi Jews, also called Ashkenazim, are Jews who are descendants of Jews from Germany, Poland, Austria and Eastern Europe.
C17951	MAGEA3_Gene	Gene_with_Unknown_or_Unclassified_Function	MAGEA3 Gene|HIP8|HYPD|MAGE-3|MAGE-3 Gene|MAGE3|MAGEA3|Melanoma Antigen Family A3 Gene|Melanoma Antigen, Family A, 3 Gene|Melanoma Antigen, Family A, 3, Gene	A gene found in some types of tumors.
C17952	Interventional_Radiology	Radiology	Interventional Radiology
C17953	Education_Level	Demographics	Education Level|EDUC|Education	A demographic parameter indicating the number of years of schooling or the highest level of achievement at school.
C17954	Falkland_Islands	Country	Falkland Islands|238|FK|FLK|Islas Malvinas	Islands in the South Atlantic Ocean, east of southern Argentina. (CIA World Factbook 2002)
C17955	Nicotine_Patch	Skin_Patch	Nicotine Patch|Nicotine Skin Patch	A transepidermal patch designed to deliver nicotine, the addictive substance contained in cigarettes, directly through the skin and into the blood stream. Used for cessation of smoking.
C17956	Aromatase_Cytochrome-P450	Cytochrome-P450	Aromatase Cytochrome P450|Aromatase|CYP19|CYP19A1|CYPXIX|Cytochrome P450 19A1|Cytochrome P450, Family 19, Subfamily A, Polypeptide 1|Cytochrome P450, Subfamily XIX|Cytochrome P450, Subfamily XIX (Aromatization of Androgens)|EC 1.14.14.1|Estrogen Synthetase|Flavoprotein-Linked Monooxygenase|Microsomal Monooxygenase|p450arom	Aromatase is a unique member of the cytochrome P450 enzyme superfamily that catalyzes formation of aromatic C18 estrogens from C19 androgens by desaturating ring A of the steroid.  One of two components of the aromatase enzyme complex, aromatase is present in many tissues including skin, muscle, fat, and nerve, where it may contribute to sex-specific differences in cellular metabolism.  The other component of aromatase is NADPH-cytochrome P450 reductase, which transfers reducing equivalents to P450(arom).  Class I cytokines such as IL6 and IL11, as well as TNF-alpha, are important regulatory factors of the CYP19 (aromatase) gene.  (from OMIM 107910 and NCI)
C17957	Foreign_Component	Business_Rules	Foreign Component|Foreign|Foreign Subpart|Foreign or Foreign Component|International Activity|International Affairs|International Aspects	An indication that all or part of the research on a grant to a US institution is either conducted in a foreign country, uses foreign subjects or their tissues or medical data, or involves collaboration with foreign researchers.
C17958	Functional_Magnetic_Resonance_Imaging	Functional_Imaging|Magnetic_Resonance_Imaging|Magnetic_Resonance_Spectroscopic_Imaging	Functional Magnetic Resonance Imaging|Functional MRI|fMRI|functional magnetic resonance imaging	A noninvasive tool used to observe functioning in the brain or other organs by detecting changes in chemical composition, blood flow, or both.
C17959	Rehabilitation_Nursing	Nursing	Rehabilitation Nursing|Restorative Nursing	Rehabilitation nursing is a specialty devoted to assisting individuals of all ages and cultural backgrounds to accomplish the tasks of daily living to their greatest potential and return to their premorbid lifestyle. (ARN)
C17960	Hypermedia	Media	Hypermedia	A computer environment in which multiple linkages enable users to move directly from one segment of audio, video, graphic, or text to another in a database.
C17961	DNA_Methylation	Methylation	DNA Methylation	The process by which methyl groups are added to nucleotides in genomic DNA.
C17962	Multimedia	Media	Multimedia	A computer-controlled presentation of some combination of audio, video, animation, graphics, still photo, and/or text where users can control the presentation and often interact with it.
C17963	BCL2_Gene	Apoptosis_Inhibitor_Gene|BCL-2_Gene_Family	BCL2 Gene|B-Cell CLL/Lymphoma 2 Gene|B-cell CLL-Lymphoma 2|BCL-2 Gene|BCL2|ced9 homolog	The BCL-2 gene encodes two isoforms from alternative splicing of the mitochondrial membrane protein BCL-2, which exhibits anti-apoptotic activity promoted by growth factor-stimulated phosphorylation by PKC. Cleavage of BCL-2 by caspases during apoptosis yields a pro-apoptotic product that stimulates further caspase activity, due to release of mitochondrial cytochrome C into the cytosol. Gene transcription is up regulated by IL2. BCL-2 consists of two exons separated by an intron. The first exon is transcribed into a 3.5 kb mRNA, spliced to produce a 5.5kb mRNA. These mRNAs encode alpha and beta isoforms, identical except for the carboxyl terminus. Overexpression of BCL-2 from a t(14;18) translocation with the Ig gene region promotes B-cell lymphomas, due to interference with apoptosis. The human gene is located at 18q21.3.
C17964	Bioinformatics	Informatics	Bioinformatics|Computational Biology	Bioinformatics derives knowledge from computer analysis of biological data. These can consist of the information stored in the genetic code, but also experimental results from various sources, patient statistics, and scientific literature. Research in bioinformatics includes method development for storage, retrieval, and analysis of the data. Bioinformatics is a rapidly developing branch of biology and is highly interdisciplinary, using techniques and concepts from informatics, statistics, mathematics, chemistry, biochemistry, physics, and linguistics. It has many practical applications in different areas of biology and medicine. (M. Nilges and Jens P. Linge, Unite de Bio-informatique Structurale, Institut Pasteur, Paris)
C17965	BRCA1_Gene	Regulatory_Gene	BRCA1 Gene|BRCA1|Breast Cancer 1 Gene|Breast Cancer 1, Early Onset Gene|Breast Cancer Type 1 Susceptibility Gene|Hereditary Breast Cancer 1|PSCP|RNF53	A gene on chromosome 17 that normally helps to suppress cell growth. A person who inherits an altered version of the BRCA1 gene has a higher risk of getting breast, ovarian, or prostate cancer.
C17966	ABCB1_Gene	Transport_Protein_Gene	ABCB1 Gene|ABC20|ABCB1|ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1 Gene|GP170|MDR-1|MDR1|MDR1 Gene|Multidrug Resistance 1 Gene|P-GP|P-Glycoprotein 1 Gene|PGY1	Human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) gene, located at 7q21.1, encodes multidrug resistance protein 1. Amplification of the ABCB1 gene is a major determinant in the development of multi-drug resistance which decreases the effectiveness of many chemotherapeutic agents used in cancer treatment.
C17967	Multidrug_Resistance_Gene	Susceptibility-Resistance_Gene	Multidrug Resistance Gene|MDR|MDR Gene	Mammalian P-glycoproteins are encoded by the MDR gene family and belong to the ATP-binding cassette vectorial transport protein class; the CFTR chloride channel is also a family member.  The human multidrug resistance 1 (MDR1) gene responds to environmental stress, including various anticancer agents.  It is a major determinant in the development of resistance to a large number of cancer chemotherapeutic agents.  MDR1 and MDR2 P-glycoproteins are large apical cell membrane proteins overproduced in multidrug-resistant (MDR) cancer cells resistant to diverse hydrophobic drugs.  P-glycoproteins act as pumps able to extrude drugs from cells at the cost of ATP hydrolysis.  MDR is primarily due to increased drug extrusion from the resistant cell.  Defense against xenobiotics may be a natural function of these P-glycoproteins.
C17968	COS-1	Monkey_Cell_Line	COS-1|COS Cells	The line was derived from the CV-1 cell line (ATCC CCL-70) by transformation with an origin defective mutant of SV40 which codes for wild type T antigen. The cells contain a single integrated copy of the complete early region of the SV40 genome.
C17969	Ku80_Protein	DNA_Repair_Protein|Ku_Protein	Ku80 Protein|ATP-Dependent DNA Helicase II, 86 kD Subunit|Ku Antigen, 80-KD Subunit|X-Ray Repair, Complementing Defective, In Chinese Hamster, 5|XRCC5	KU80 protein is the 80 kD subunit of the KU autoantigen, a heterodimeric DNA repair complex that binds DNA double-strand breaks, is the DNA-binding component of the DNA-dependent protein kinase, and facilitates repair by nonhomologous end-joining.  KU70 and KU80 form a dyad-symmetrical molecule with a preformed ring that encircles duplex DNA.  KU protein is also involved in V(D)J recombination.  KU is identical to DNA helicase II, an ATP-dependent DNA unwinding enzyme.  (from OMIM 194364 and NCI)
C17970	AP-2_Beta_Protein	AP-2_Family_Transcription_Factor	AP-2 Beta|AP-2 Transcription Factor Beta|AP2-Beta|Activating Enhancer-Binding Protein 2 Beta|TFAP2B|TFAP2B Protein|Transcription Factor AP-2 Beta|Transcription Factor AP2-Beta	A transcription factor that belongs to the AP-2 family and binds viral and cellular enhancers containing the consensus 5'-GCCNNNGGC-3' DNA motif. AP-2 Beta appears to regulate expression of genes required for ectodermal development and retinoic acid-induced differentiation of neuroectodermal cells. (from SWISS-PROT Q92481, OMIM 601601, and NCI)
C17971	Caveolin-1	Signaling_Protein	Caveolin 1|CAV|CAV1|Caveolae Protein, 22kD|Caveolin 1, Caveolae Protein, 22kD|Caveolin-1|VIP21	Caveolin 1 (CAV1), encoded by the CAV1 gene, is a scaffolding protein and the main component of the caveolae plasma membranes found in most cell types. CAV1 and CAV2 form Caveolin, a stable hetero-oligomeric complex important in the formation and maintenance of caveolae. In the absence of caveolin no morphologically identifiable caveolae exist, with one exception where in neuronal cells CAV 1 and CAV 2 are expressed but there are no morphologically recognizable caveolae. Caveolin 1 links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. Caveolin expression is correlated both to oncogenic transformation and its reversal. CAV1 is a tumor suppressor candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. Alternative splicing results in 2 isoform proteins (alpha, beta). (NCI)
C17972	ERCC6_Protein	Retired_Concepts	ERCC6 Protein|CSB Protein|Cockayne Syndrome B Repair Protein|ERCC6|Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6
C17973	LMO2_Gene	Transcription_Factor_Gene	LMO2 Gene|LIM Domain Only 2 (Rhombotin-Like 1) Gene|LMO2|RBTN2|RBTNL1|RHOM2|Rhombotin 2 Gene|Rhombotin-Like 1 Gene|T-Cell Translocation Gene 2|TTG2	Human LMO2 Gene (LMO family) at 11p13 encodes Rhombotin 2, which functions in hematopoiesis.  Part of a multi-protein transcription regulatory complex that includes GATA-1, rhombotin 2 binds to TAL1 protein and interacts with RB binding protein-2, enhancing transcription.  Chromosomal translocations of LMO2 are associated with T-cell leukemias. (from SWISS-PROT, OMIM, and NCI)
C17974	Rhombotin-2	Transcription_Factor	Rhombotin 2|Cysteine-Rich Protein TTG-2|LIM Domain Only 2|LIM-Only Protein 2|LMO2|LMO2 Protein|Lim Domain Only 2 Protein|Rhombotin 2 Protein|Rhombotin-Like 1|Rhombotin-Like 1 Protein|T-Cell Translocation Gene 2 Protein|T-Cell Translocation Protein 2|TTG-2 Protein	Rhombotin 2, an LMO (LIM-only) family member that functions in hematopoiesis, is encoded by the LMO2 gene. With two LIM domains and a cysteine-rich motif, rhombotin 2 is part of a multi-protein transcription regulatory complex that includes GATA-1. LMO2 protein binds to the bHLH TAL1 protein and interacts with retinoblastoma binding protein-2, enhancing transcription. Chromosomal translocations involving LMO2 are associated with T-cell leukemias.  (from OMIM 180385 and NCI)
C17975	Vascular_Endothelial_Growth_Factor_Receptor-1	Vascular_Endothelial_Growth_Factor_Receptor	Vascular Endothelial Growth Factor Receptor 1|FLT1|Flt-1|Receptor Tyrosine Kinase,Class V|Tyrosine Protein Kinase FRT|Tyrosine Protein Kinase Receptor FLT|VEGFR|VEGFR-1|VEGFR1|Vascular Endothelial Growth Factor Receptor	Gene product of the FLT1 proto-oncogene.  A receptor tyrosine kinase, thought to regulate endothelial cell-cell or cell-matrix interactions during vascular development.
C17976	Rho_Guanine_Nucleotide_Exchange_Factor-5	Guanine_Nucleotide_Exchange_Factor	Rho Guanine Nucleotide Exchange Factor 5|ARHGEF5|GEF5|TIM|TIM1|Transforming Immortalized Mammary Protein|p60	This is a 60 kD protein containing a Dbl-homology domain, which is shared by several signal transducing molecules implicated as regulators of small GTP-binding proteins. TIM is thought to be involved in control of cytoskeletal organization through regulation of small GTP-binding proteins.  (from OMIM 600888 and NCI)
C17977	Nuclear_Receptor_Coactivator-1	Transcription_Coactivator	Nuclear Receptor Coactivator 1|F-SRC-1|NCOA1|NCoA-1|SRC1	Nuclear Receptor Coactivator 1 is a co-activator for the full transcriptional activity of ligand-activated PGR, ESR, GRL, THR, and RXRA through their DNA response elements. SRC1 can also enhance the transcriptional activity of SP1, but not E2F, E47, or CREB. SRC1 has a glutamine-rich and a serine/threonine-rich region. SRC1 can also bind to TBP and to TFIIB, in addition to nuclear hormone receptors in a ligand-dependent manner; SRC1 may bridge nuclear hormone receptors with general transcription factors. Studies suggest a dual role for SRC1 in chromatin remodeling and in recruitment/stabilization of general transcription factors.  (from OMIM 602691 and NCI)
C17978	PTK2B_Protein_Tyrosine_Kinase-2_Beta	FAK_Family_Tyrosine_Kinase	PTK2B Protein Tyrosine Kinase 2 Beta|CAK Beta|Cell Adhesion Kinase Beta|PTK2B|PYK2 Kinase|Proline-rich Tyrosine Kinase 2|RAFT Kinase|Related Adhesion Focal Tyrosine Kinase	Kinase involved with apoptosis regulation in multiple myeloma.  Regulated by IL-6 and SHP-2 phosphatase
C17979	Epithelial_Membrane_Protein-1	Transmembrane_Protein	Epithelial Membrane Protein 1|B4B Protein|CL-20|CL-20 Protein|EMP-1|EMP1|EMP1 Protein|Epithelial Membrane Protein-1|TMP|Tumor-Associated Membrane Protein	epithelial membrane protein-1.  Thought to be involved in cell-cell interactions and the control of cell proliferation. Found to be highly expressed in brain tumor cells but not in normal brain.
C17980	Bloom_Syndrome_Protein	RecQ_Helicase_Family_Protein	Bloom Syndrome Protein|BLM|BLM Protein|DNA Helicase, RECQ-Like, Type 2	BLM protein is a glycopeptide of 417 amino acids within which ATP binding domain is in amino acid 689-696, DEAH box in 795-798, and 2 putative nuclear localization signals in the C-term in 1334-1349.  It is expressed at high level in S phase, and persists in G2/M and sharply declines in G1.  It function as a 3'-5'DNA helicase, and probably plays a role in DNA replication and repair.  It participates in a supercomplex of BRCA1 -associated proteins named BASC (BRCA1-Associated genome Surveillance Complex).
C17981	Cyclin-B1	Cyclin	Cyclin B1|CCNB|CCNB1|CGB1|Cyclin B|G2/Mitotic-Specific Cyclin B1	Cyclin B1 is essential for control of the G2/M transition and the gene is expressed predominantly in the G2/M phase of cell division.  Complexed with p34(cdc2), cyclin B1 forms mitosis-promoting factor (MPF), a serine/threonine kinase holoenzyme complex.  Cyclin B1 imparts substrate specificity to MPF. Phosphorylation of cyclin B1 regulates nuclear translocation of MPF during prophase, essential for the induction and coordination of M-phase events.  During cell cycle progression, a change in PLK1 kinase activity appears to phosphorylate cyclin B1 and stimulate nuclear entry of cyclin B1. (from SWISS-PROT P14635, OMIM 123836, and NCI)
C17982	Mothers_Against_Decapentaplegic_Homolog-4_Protein	Signaling_Protein	Mothers Against Decapentaplegic Homolog 4|DPC4 Protein|MAD4|MADH4|MAX-Interacting Transcriptional Repressor|SMA- and MAD-Related Protein 4|SMAD4 Protein	The SMAD4 tumor suppressor protein specifically recognizes an eight base pair palindromic DNA sequence and is critical for transmitting TGFB, and related cytokine signals, to the cell nucleus to mediate transcriptional activation of target genes.  The MADH4 gene is a cloned gene for Juvenile Polyposis, associated with colon cancer.  (from OMIM 600993 and NCI)
C17983	G-s_Alpha	Heterotrimeric_G_Protein_Subunit	G(s) Alpha	G(s) alpha is a subunit of the heterotrimeric G(s) protein.  G(s) alpha couples hormone-receptor binding to adenylyl cylase activity and cAMP signaling.
C17984	Prostaglandin-Endoperoxide_Synthase-2	Cyclooxygenase	Prostaglandin-Endoperoxide Synthase 2|COX-2|COX2|Cyclo-Oxygenase-2|Cyclooxygenase|Cyclooxygenase 2|Cyclooxygenase-2|PGH Synthase 2|PGHS-2|PGHS2|PHS II|PTGS|PTGS2|Prostaglandin G/H Synthase 2|Prostaglandin G/H Synthase and Cyclooxygenase|Prostaglandin H2 Synthase 2|Prostaglandin-Endoperoxide Synthase	A rate-limiting enzyme in the conversion of arachidonic acid to prostaglandins, COX-2 is expressed in cells involved in inflammatory processes and has been implicated in tumor promotion as well as a negative prognosis.  COX-2 is expressed in 50% of pancreatic tumors.  Anti-inflammatory glucocorticoids are potent inhibitors of cyclooxygenase.  Inhibition or lack of COX-2 reduces tumor growth and blocks angiogenesis.  Aspirin and etodolac, both COX-2 inhibitors, inhibit growth of pancreatic cancer cell lines.  (from Cancer 2001. 91:333, Medscape, OMIM 600262, and NCI)
C17985	CKR5	Retired_Concepts	CKR5	CKR5 is a G protein coupled receptor for beta-chemokines.  It also functions as a co-factor for macrophage-tropic HIV-1 infection.
C17986	Metalloprotease-RGD-Disintegrin_Protein	ADAM_Family_Protein	Metalloprotease-RGD-Disintegrin Protein|A Disintegrin and Metalloproteinase Domain 15|ADAM15|EC 3.4.24.-|MDC15|Metalloproteinase-Like Disintegrin-Like and Cysteine-Rich Protein 15|Metargidin	MDC-15; ADAM-15; metargidin.  Member of a sequence-related family of cysteine-rich membrane proteins containing metalloproteinase-like and disintegrin-like domains; contains an RGD sequence in its disintegrin domain.
C17987	Somatostatin_Receptor-4	Somatostatin_Receptor	Somatostatin Receptor 4|SSTR4	Somatostatin binds to a group of structurally related tissue-specific high-affinity integral membrane GPCRs (family 1), coupled via G proteins to inhibition of adenylyl cyclase.  Somatostatin Receptor 4 is specifically expressed in human fetal and adult brain, lung, and stomach, and less in kidney, pituitary, and adrenals.  SSTR4 also activates arachidonate release and the MAP kinase cascade.  (from OMIM 182454, SWISS-PROT P31391, and NCI)
C17988	Cyclin-D1	Cyclin	Cyclin D1|BCL1|CCND1|Cyclin D|D11S287E|G1/S-Specific Cyclin D1|PRAD1|U21B31	Essential for control of the G1/S transition, cyclin D1 interacts with CDK4 and CDK6 to form a serine/threonine kinase holoenzyme and imparts substrate specificity to the complex.  RB regulates cyclin D1 gene expression.  Cyclin D1 expression may identify Barrett's esophagus patients at high risk for esophageal carcinoma; risk of progression to adenocarcinoma exhibits an odds ratio of 6.85.  The BCL1 and PRAD1 oncogenes involve cyclin D1 gene translocations.  (from J Natl Cancer Inst 2000. 92:1282 & 1316, SWISS-PROT P24385, OMIM 168461, and NCI)
C17989	Adenovirus_Death_Protein	Adenovirus_Protein	Adenovirus Death Protein	An adenovirus nuclear membrane glycoprotein synthesized from the E3 transcription unit in large amounts late in infection.  It is required for efficient lysis of infected cells.  It is being investigated for use in targeting tumors for death by a suicide mechanism.
C17990	p300_CBP-Associated_Factor	Histone_Acetylase	p300/CBP-Associated Factor|CREBBP-Associated Factor|EC 2.3.1.-|Histone Acetylase PCAF|P/CAF|PCAF	CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation. p300/CBP-Associated Factor, encoded by the PCAF gene, displays in vivo binding activity with CBP and p300. This protein has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that it plays a direct role in transcriptional regulation. It also associates with NF-kappa-B p65. Protein kinase A regulates the transcriptional activity of NF-kappa-B by modulating its interaction with CPB/p300. (from LocusLink)
C17991	Spermidine-Spermine_N1-Acetyltransferase	Acyltransferase	Spermidine/Spermine N1-Acetyltransferase|Diamine N-Acetyltransferase|EC 2.3.1.57|Putrescine Acetyltransferase|SAT|SPD/SPM acetyltransferase|SSAT|Spermidine N1-Acetyltransferase	Encoded by human SAT Gene, 171-aa 20-kDa cytoplasmic Spermidine/Spermine N1-Acetyltransferase is a highly regulated homotetrameric rate-limiting enzyme in the catabolic polyamine metabolism pathway that regulates intracellular polyamine concentration and polyamine transport out of cells. SAT acts on putrescine, spermidine, spermine, N(1)-, and N(8)-acetylspermidine and catalyzes N(1)-acetylation of spermidine and spermine. (NCI)
C17992	Cell_Biology	Biology	Cell Biology|Cellular Biology	The study of the internal workings of cells at the microscopic and molecular level. (On-Line Medical Dictionary)
C17993	Nutritional_Status	Personal_Attribute	Nutritional Status
C17994	Dietary_History	Personal_Medical_History	Dietary History	A history of daily food intake
C17995	Light_Microscopy	Microscopy	Light Microscopy	Light Microscopy is a technique for producing visible images of structures or details which are too small to be otherwise seen by the human eye. It involves passing light transmitted through or reflected from the subject through a series of lenses to be detected directly by the eye, imaged on a photographic plate, or captured digitally. (NCI2005)
C17996	Cell-Mediated_Immunity_Multitest	Immunologic_Techniques	Cell-Mediated Immunity Multitest	Multitest CMI is a diagnostic technique for detection of anergy (nonresponsiveness to antigens) by means of delayed hypersensitivity skin testing. This test uses seven antigens: tuberculin, tetanus, diphtheria, Streptococcus, Candida, Trichophyton, and Proteus to test for cutaneous delayed-type hypersensitivity responses in humans. The test is administered by pressing the antigen heads of the Multitest applicator firmly onto the volar surface of the lower arm. A positive reaction to an antigen is manifest as an inflammatory response at the site of administration.
C17997	Immune	Personal_Attribute	Immune	Protected against infectious disease by either specific or non-specific mechanisms. (On-line Medical Dictionary)
C17998	Unknown	Business_Rules	Unknown	Unknown, not observed, not recorded, or refused.
C17999	Scan	Medical_Image	Scan|Scans|scans	Pictures of structures inside the body. Scans often used in diagnosing, staging, and monitoring disease include liver scans, bone scans, and computed tomography (CT) or computerized axial tomography (CAT) scans and magnetic resonance imaging (MRI) scans. In liver scanning and bone scanning, radioactive substances that are injected into the bloodstream collect in these organs. A scanner that detects the radiation is used to create pictures. In CT scanning, an x-ray machine linked to a computer is used to produce detailed pictures of organs inside the body. MRI scans use a large magnet connected to a computer to create pictures of areas inside the body.
C18000	Histopathologic_Grade	Cancer_Histology	Histopathologic Grade|GD|Grade|Grading|Histologic Grade|grade|grading	A system for classifying cancer cells in terms of how abnormal they appear when examined under a microscope. The objective of a grading system is to provide information about the probable growth rate of the tumor and its tendency to spread. The systems used to grade tumors vary with each type of cancer. Grading plays a role in treatment decisions.
C18001	Digital_X-Ray	Imaging_Technique	Digital X-Ray	Acquisition or display of radiographic images using digital techniques; includes digital video fluoroscopy, scan-projection radiography (SPR), digital subtraction and angiography (DSA), digital intravenous angiography (DIVA), and computed tomography. (CRC Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)
C18002	Home	Sites_of_Care_Delivery	Home	Home; a person's permanent place of residence.
C18003	Vital	General_Modifier	Vital|VTL|vital	Necessary to maintain life. Breathing is a vital function.
C18004	Staging_System	Classification	Staging System
C18005	_3-Dimensional	Properties_or_Attributes	3-Dimensional|3-D|3-dimensional|3D	3-D. A graphic display of depth, width, and height.
C18006	ST7_Gene	Gene_with_Unknown_or_Unclassified_Function	ST7 Gene|ETS7q|FAM4A1|HELG|RAY1|SEN4|ST7|ST7OT3|Suppression of Tumorigenicity 7|Suppression of Tumorigenicity 7 Gene|TSG7	Studies show that the ST7 gene is widely expressed and often disrupted by mutation or deletion in tumors arising from epithelial cells, such as breast, prostate, colon and ovary.  The gene is predicted to encode a highly conserved protein, with orthologous sequences in mouse, cow, pufferfish, and C. elegans.  Such conservation suggests a critical role for ST7, as is the case for most tumor suppressor genes.  (from OMIM 600833 and NCI)
C18007	Antarctica	Country	Antarctica|010|AQ|ATA|AY	The continent lying mostly south of the Antarctic Circle. (CIA World Factbook 2002)
C18008	TNM_Ovary_Neoplasm_Staging	Staging_System	TNM Ovary Neoplasm Staging|TNM Neoplasm Staging of the Ovary|TNM Ovary Tumor Staging|TNM Tumor Staging of the Ovary
C18009	Tumor_Tissue	Tissue_Sample	Tumor Tissue
C18010	Roller_Bottle	Cell_Culture_System	Roller Bottle	Bottles utilized as vessels for intermediate scale preparations of attachment-dependent cultured cells.  Denoted 'roller bottles' because they are slowly rotated, or rolled, to permit homogeneous cell growth on all the available inner surface of the bottle.
C18011	Immunology	Biological_Sciences	Immunology|Immunology (Including BRMP)|Immunology (NCI Program)|immunology	Immunology is the study of the immune system and its reaction to pathogens, as well as its malfunctions (autoimmune diseases, allergies, rejection of organ transplants). (from Wikipedia)
C18012	Carcinogen_Effect_in_Offspring	Pathologic_Process	Carcinogen Effect in Offspring	Alteration of any condition or process in an offspring that results form the effect of a carcinogen in a parent.
C18013	Megakaryopoiesis	Myelopoiesis	Megakaryopoiesis|Megakaryocytopoiesis	Megakaryopoiesis is the production of megakaryocytes in bone marrow that produce platelets.
C18014	Fecal_Occult_Blood_Test	Test|Test_Generic	Fecal Occult Blood Test|FOBT|Guaiac Smear Test|Hemoccult|Stool guaiac test|fecal occult blood test	(FEE-kul o-KULT) A test to check for blood in stool. (Fecal refers to stool; occult means hidden.)
C18015	Prostatic_Acid_Phosphatase	Phosphatase	Prostatic Acid Phosphatase|ACPP|PAP|prostatic acid phosphatase	(FOS-fa-tays) PAP. An enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer.
C18016	Loss_of_Heterozygosity	DNA_Sequence_Alteration	Loss of Heterozygosity|LOH	A genetic abnormality that is characterized by the partial loss of specific gene function via the deletion or mutation of one allele of a heterozygous gene locus. When this occurs at a tumor suppressor gene locus in a phenotype that already contains an abnormal allele, loss of heterozygosity can contribute to neoplastic transformation.
C18017	T-Cell_Receptor_Gene	Immunoprotein_Gene	T-Cell Receptor Gene	The T-cell antigen receptors consist of a heterodimer of integral membrane glycoproteins. Two distinct receptors exist, alpha/beta and gamma/delta. Alpha/beta receptors are found on helper and cytotoxic T-cells and are specific for antigenic peptides presented in association with MHC gene products. Gamma/delta receptors, found in association with CD3, directly recognize proteins and non-proteinacious phospho-ligands. Alpha/beta and gamma/delta are non-covalently associated with CD3-gamma, -delta, -epsilon, and -zeta proteins, forming the TCR-CD3 complex, which activate MAPKs and JNK1 through the CD3 antigens, the adaptor protein LAT, and tyrosine kinases LCK and ZAP70. The genes for T-cell receptor subunits are encoded by distinct gene elements that are assembled by somatic rearrangement during T-cell development. Translocations and inversions of these loci are observed in human T-cell leukemias and lymphomas.
C18018	Chemokine_Receptor	Cytokine_Receptor	Chemokine Receptor	Encoded by Chemokine Receptor Genes (GPCR Family), cell surface Chemokine Receptors are seven-transmembrane G protein-coupled receptor glycoproteins that bind to chemokines and mediate the migration of pro-inflammatory cells. Like chemokines, the chemokine receptors can be divided, according to variations in a shared cysteine motif, into at least three structural branches: CR, CCR, and CXCR. (NCI)
C18019	Leukopoiesis	Hematopoiesis	Leukopoiesis|White Blood Cells/Stem Cells/Leukopoiesis	The process of generating white blood cells or leukocytes. These cells are derived from the hematopoietic stem cells of the bone marrow and can be generated by one of two separate pathways. One pathway involves myeloid stem cells while the other involves lymphoid stem cells.
C18020	Diagnostic_Procedure	Techniques	Diagnostic Procedure|Diagnostic Method|Diagnostic Technique|diagnostic procedure	A method used to identify a disease.
C18021	CCND1_Gene	Cyclin_Gene	CCND1 Gene|BCL1|CCND1|Cyclin D1 Gene|D11S287E|PRAD1|U21B31	The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis. (LocusLink)
C18022	CDKN2A_Gene	Cyclin-Dependent_Kinase_Inhibitor_Gene	CDKN2A Gene|ARF|CDK4I|CDKN2|CDKN2 Gene|CDKN2A|CMM2|Cyclin-Dependent Kinase Inhibitor 2A Gene|INK4|INK4A|MLM|MTS1|TP16|TSG9A|p14ARF|p16INK4a	This gene at 9p21 encodes p16 (a cyclin dependent kinase inhibitor) and p14 (an upstream regulator of p53) via alternative promoters and splicing. The unitary inheritance of p16 and p14 may promote cooperation in cell cycle control through their relations to the RB and p53 growth control pathways. p16 gene regulation by ETS is potentiated by RAS-RAF-MEK kinase signaling and inhibited by the HLH protein ID1. Bound to CDK4, p16 inhibits CDK4 interaction with cyclin D and passage through late G1. It inhibits RB phosphorylation by CDK4 and CDK6. Bound to MDM2, p14 promotes MDM2 degradation and blocks MDM2-induced p53 degradation, leading to p53 stabilization and accumulation. CDKN2A disruptions such as chromosomal inversions, translocations, and deletions are associated with malignancies and in a variety of malignant cell lines from glioma, nonsmall cell lung cancer, leukemia, melanoma and tumors of the breast, bone, skin, bladder, kidney, and ovary.
C18023	DNA_Polymerase_Beta	DNA-Directed_DNA_Polymerase	DNA Polymerase Beta|Beta DNA polymerase	Human DNA polymerase beta protein (334 aa 38 kDa) is encoded by the human DNA polymerase beta (POLB) gene. This monomer protein is a DNA repair enzyme that catalyzes "gap-filling" DNA synthesis in a stepwise, distributive manner during base excision repair. This enzyme is required for DNA maintenance, replication, recombination, and drug resistance.
C18024	Cytochrome-P450-2A5	Mouse_Protein	Cytochrome P450 2A5	Mouse cytochrome P450 2a5 protein (494 aa, 57 kD) is encoded by the mouse Cyp2a5 gene. This enzyme is an unspecific, membrane-bound, monooxygenase located in the endoplasmic reticulum. It catalyzes the metabolism of a variety of substrates including fatty acids, steroids and xenobiotics.
C18025	Ap3A-Hydrolase	Hydrolase	Ap3A Hydrolase|AP3Aase|Diadenosine 5',5'''-P1,P3-triphosphate Hydrolase|Dinucleosidetriphosphatase|FHIT|FHIT Protein|bis(5'-adenosyl)-triphosphatase	FHIT protein is a 147-amino acid AP3A hydrolase.  The FHIT preferred substrate, AP3A (diadenosine 5-prime,5-triple prime-P(1),P(3)-triphosphate), and AP4A have been proposed to have various intracellular functions, including regulation of DNA replication and signaling stress responses. (from OMIM)
C18026	FPS-FES-Related_Tyrosine_Kinase	Protein_Tyrosine_Kinase	FPS/FES-Related Tyrosine Kinase|C-FER|FER Protein|P94-FER|Phosphoprotein NCP94|TYK3 Protein|Tyrosine-Protein Kinase FER	FER (FPS/FES related) protein is a tyrosine kinase expressed in lymphoid cells; phosphoprotein NCP94.  Inhibition of CDH2 (the cytoplasmic domain) or of beta-1 integrin function results in release of FER from the cadherin complex and accumulation in the integrin complex, suggesting that FER may shuttle between cadherin and integrin complexes, perhaps mediating cross-talk between CDH2 and ITGB1.  (from OMIM 176942 and NCI)
C18027	Core-Binding_Factor_Beta_Subunit	Transcription_Coactivator	Core-Binding Factor, Beta Subunit|CBF-Beta|CBFB|Core-Binding Factor Beta|Core-Binding Factor Beta Subunit|PEA2-Beta|PEBP2-Beta|PEBP2B|Polyomavirus Enhancer Binding Protein 2 Beta Subunit|SL3-3 Enhancer Factor 1 Beta Subunit|SL3/AKV Core-Binding Factor Beta Subunit	Part of the heterodimeric transcription factor Core-Binding Factor.  CBF beta does not bind to DNA directly, but increases the affinity and stabilizes the binding of the CBF alpha (transcription factor AML1) for the CBF enhancer/promoter DNA site in TCR genes.  CBF appears to regulate hematopoietic differentiation.  Disruption of CBFB is associated with some leukemias.  (from SWISS-PROT Q13951, OMIM 121360, and NCI)
C18028	Telomeric_Repeat_Binding_Factor-1	Telomeric-Repeat_Binding_Factor	Telomeric Repeat Binding Factor 1|TERF1|Telomeric Repeat Binding Factor (NIMA-Interacting) 1|Telomeric-Repeat Binding Factor 1	This protein is a telomere specific binding protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. (from LocusLink)
C18029	Vascular_Endothelial_Growth_Factor_Receptor_3	Retired_Concepts	Vascular Endothelial Growth Factor Receptor 3
C18030	Non-Receptor_Type_11_Protein_Tyrosine_Phosphatase	Protein_Tyrosine_Phosphatase	Protein Tyrosine Phosphatase, Non-Receptor Type 11|PTPN11|Protein Tyrosine Phosphatase 2C|SHP2 Phosphatase	Phosphatase involved in apoptosis regulation in multiple myeloma.  Normally activated by IL-6, it regulates the activity of RAFT Kinase
C18031	Caspase-3	Caspase	Caspase-3|Apopain|CASP-3|CASP3|CPP-32|CPP32|CPP32B|Caspase 3, Apoptosis-Related Cysteine Protease|Cysteine Protease CPP32|EC 3.4.22.-|PARP Cleavage Protease|SCA-1|SREBP Cleavage Activity 1|Yama	Caspase-3, encoded by the CASP3 gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Caspase-3 is a central player in mediating apoptosis and is the most widely studied caspase. This protein cleaves and activates caspases 6, 7 and 9, and itself can be processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of the CASP3 gene results in two transcript variants which encode the same protein. (From LocusLink and NCI)
C18032	hHLTF_Protein	SWI2-SNF2_Family_Protein	hHLTF Protein|HIP116|Human Helicase-Like Transcription Factor|SMARCA3|SNF2L3|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 3|Zbu1 Gene Product	This protein is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. This protein contains a RING finger DNA binding motif. Two transcript variants encoding the same protein have been found for this gene. However, use of an alternative translation start site produces an isoform which is truncated at the N-terminus as compared to the full-length protein. (LocusLink)
C18033	HKR3_Protein	GLI_Family_Protein	HKR3 Protein|GLI-Kruppel Family Member HKR3 Protein|HKR3	A member of the GLI family of Kruppel-related DNA-binding proteins, the 77 kD HKR3 Protein contains eleven C2H2 zinc fingers, an N-terminus tramtrack-associated box, and an acidic activation domain.  (from OMIM 165270 and NCI)
C18034	Mothers_Against_Decapentaplegic_Homolog-3_Protein	Signaling_Protein	Mothers Against Decapentaplegic Homolog 3|MAD Homolog 3|MADH3|Mothers Against Decapentaplegic Homolog 3 Protein|Mothers Against Decapentaplegic, Drosophila, Homolog of, 3|SMA- and MAD-Related Protein 3|SMAD3 Protein	Regulated by TGF-beta receptors, Mothers Against Decapentaplegic Homolog 3 is an effector of the TGF-beta response.  MADH3 is associated with and phosphorylated by the ligand-bound receptor complex.  MADH3 and MADH4 synergize to induce strong TGF-beta-like responses.  SMAD3 and SMAD4 proteins specifically recognize an eight base pair palindromic DNA sequence that confers TGF-beta responsiveness to a minimal promoter. (from OMIM 603109 and NCI)
C18035	Somatostatin_Receptor-1	Somatostatin_Receptor	Somatostatin Receptor 1|SSTR1	Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. Thish protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach. (LocusLink)
C18036	PU-1_Transcription_Factor	ETS_Family_Protein	PU.1 Transcription Factor|SPI1|SPI1 Gene Product|SPI1 Protein	Normally expressed in all hematopoietic lineages, except T-cells, the ETS-domain PU.1 Transcription Factor is essential for development of myeloid (osteoclast progenitors) and B-lymphoid cells.  Graded PU.1 expression appears to specify distinct cell fates in the hematopoietic system; a low concentration induces the B-cell fate, while a high concentration promotes macrophage differentiation.  PU.1 is thought to regulate transcription of FMS and CD18/11B, proteins central to the osteoclast phenotype, and is required for p47-phox promoter activity in myeloid cells.  PU.1 expression is increased with the induction of osteoclastogenesis by 1, 25-dihydroxyvitamin D3.  (from OMIM 165170 and NCI)
C18037	Exostosin-2	Glycosyltransferase	Exostosin-2|EXT2|Exostoses (multiple) 2	EXT2 is a presumed tumor suppressor.  EXT1 and EXT2 proteins are type II transmembrane glycoproteins that appear to form a heterooligomeric complex having glycosyl transferase activity involved in heparan sulfate polymerization.  EXT2 interacts with a UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase.  EXT1 and EXT2 proteins may play a role in modulation/diffusion of hedgehog signaling.  EXT2 is involved in hereditary multiple exostoses.  (from OMIM 133701 and NCI)
C18038	Thrombospondin-2	Thrombospondin	Thrombospondin 2|THBS2|TSP-2|TSP2|Thrombospondin II|Thrombospondin-2	Thrombospondin 2 is a secretory product of platelet alpha-granules and a product of many other cells.  It is a multifunctional protein that contains binding sites for thrombin, fibrinogen, heparin, fibronectin, plasminogen, plasminogen activator, collagen, laminin, etc.  It functions in many cell adhesion and migration events, including platelet aggregation and granule cell migration during histogenesis of the cerebellar cortex.  Two cysteine residues are involved in interchain disulfide linkage and trimer assembly.  Cells express both homotrimeric and heterotrimeric forms of the protein (with THBS1).  (from OMIM 188061 and NCI)
C18039	Cytokeratin-19_Fragment-21-1_Peptide	Protein_Fragment	CYFRA 21-1|Cytokeratin-19 Fragments 21-1	A fragment of cytokeratin 19.  A tumor marker.  Reported to be a sensitive serum marker of recurrent breast cancer.  May also be a good prognostic marker, with patients with high serum levels of the marker having shorter disease-free survival. (from Cancer 2000;89:1285-1290 via Medscape)
C18040	TEL-AML1_Fusion_Protein	Oncoprotein	TEL-AML1 Fusion Protein|TEL-AML1	Fusion protein containing the helix-loop-helix domain of TEL, a member of the ETS-like family of transcription factors, and the DNA-binding and transactivation domains of the transcription factor AML1.  Encoded by the TEL-AML1 gene, which arises from a chromosomal translocation.
C18041	Thymosin_Beta-15	Actin-Binding_Protein	Thymosin Beta-15|TMSB15	Thymosin Beta-15 (Thymosin-Beta Family) may be an actin-binding protein and positive cell motility factor that opposes the activity of motility suppressor KAI1. Involved in metastasis and prostate cancer, TMSB15 may be a new target for therapy. (from OMIM and NCI)
C18042	Angiopoietin-1	Angiogenesis_Promoter	Angiopoietin-1|ANG1|ANGPT1|Angiopoietin 1	Encoded by human ANGPT1 Gene, Angiopoietin-1 is a 498-amino acid 57.5 kD (precursor) secreted glycoprotein ligand for the endothelial TIE2 receptor tyrosine kinase and contains a predicted coiled-coil domain and a fibrinogen-like C-terminus.  Its expression in endothelial and early hematopoietic cells suggests an action in vascular development.  Antagonized by Angiopoietin-2, ANGPT1 structure differs from other angiogenic factors or ligands for receptor tyrosine kinases and its actions are distinct from VEGF, necessary for early stages of vascular development.  ANGPT1 acts in vascular remodeling, maturation, and stability.  ANGPT1 and TIE1 are critical for right side, but not left side, venous system development.  (OMIM, Swiss-Prot, and NCI)
C18043	Somatostatin_Receptor-3	Somatostatin_Receptor	Somatostatin Receptor 3|SSTR3	Somatostatin binds to a group of structurally related tissue-specific high-affinity integral membrane GPCRs (family 1), coupled via G proteins to inhibition of adenylyl cyclase.  Somatostatin Receptor 3 is readily detected in brain, pituitary, and pancreatic islets.  (from OMIM 182453, SWISS-PROT P32745, and NCI)
C18044	CDC6_Cell_Division_Cycle-6_Homolog_Protein	Licensing_Factor	CDC6 Cell Division Cycle 6 Homolog|CDC18 (Cell Division Cycle 18, S. pombe, Homolog)-Like|CDC18L|CDC6|CDC6 Cell Division Cycle 6 Homolog (S. Cerevisiae)|CDC6 Homolog|CDC6-Related Protein|Cell Cycle Controller CDC6|Cell Division Cycle 18, S. pombe, Homolog-Like|HsCDC18|HsCDC6|hCdc6	CDC6 Cell Division Cycle 6 Homolog, encoded by the CDC6 gene, is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cycle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cycle is regulated through its phosphorylation by Cdks. Transcription of this protein is regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. (From LocusLink and NCI)
C18045	Caspase-1	Caspase	Caspase-1|CASP-1|CASP1|Caspase 1, Apoptosis-Related Cysteine Protease|Caspase 1, Apoptosis-Related Cysteine Protease (Interleukin 1, Beta, Convertase)|EC 3.4.22.36|ICE|IL-1 Beta Converting Enzyme|IL-1BC|IL-1b Converting Enzyme|IL1B-Convertase|IL1BC|IL1BCE|Interleukin 1-B Converting Enzyme|Interleukin 1-Beta Convertase|Interleukin-1 Beta Converting Enzyme|P45	Caspase-1, encoded by the CASP1 gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of the similar gene in mouse suggested its role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. (From LocusLink)
C18046	Endostatin	Angiogenesis_Inhibitory_Protein	Endostatin|COL18A1	Endostatin is a 20 kD C-terminal fragment of collagen XVIII that inhibits endothelial proliferation and angiogenesis.  Cell surface proteoglycans glypican-1 and glypican-4 are endostatin receptors.  Heparan sulfate glycosaminoglycans of glypican are critical for endostatin binding.  Endostatin also promotes renal tubular cell branching morphogenesis.  (from OMIM 120328 and NCI)
C18047	MAFG_Protein	MAF_Family_Protein	MAFG Protein|MAFG|Small MAF Protein G	Globin gene expression is regulated through NFE2 elements upstream of alpha- and beta-gene clusters.  NFE2 DNA-binding involves a heterodimer containing a ubiquitous small MAF protein (MAFF, MAFG, or MAFK) and tissue-specific p45 NFE2.  Both subunits are members of the AP-1-like superfamily of bZIP proteins.  MAFG also forms heterodimers with NRF1 and NFE2-related factor 2, which stimulate transcription from NFE2 sites.  (from OMIM 602020 and NCI)
C18048	GLI2_Protein	GLI_Family_Protein	GLI2 Protein|GLI-KRUPPEL Family Member 2 Protein|GLI2|Glioma-Associated Oncogene Homolog 2 Protein|TAX Helper Protein	A Kruppel family protein, GLI2 Protein contains five DNA-binding zinc finger repeats and is implicated in transduction of the SHH signal.  GLI2 is a putative oncogene in the development of human BCC.  The expression of GLI2 in skin results in activation of multiple SHH target genes.  (from OMIM 165230 and NCI)
C18049	Glutathione_S-Transferase-Pi	Glutathione_S-Transferase	Glutathione S-Transferase Pi|Fatty Acid Ethyl Ester Synthase III, Myocardial|GST-Pi|GST3|GSTP1|Glutathione S-Transferase 3	GST-pi is the anionic isozyme of glutathione S-transferase.  GST enzymes play an important role in detoxification by conjugating hydrophobic and electrophilic compounds with reduced glutathione.  GST-pi appears to be present in all tissues, with the exception of red blood cells, and is over expressed in multidrug-resistant cells.  GST-pi may be fatty acid ethyl ester synthase III, a heart enzyme that nonoxidatively metabolizes ethanol.  (from OMIM 134660 and NCI)
C18050	Exostosin-1	Glycosyltransferase	Exostosin-1|EXT1|Exostoses (multiple) 1	Multiple exostoses type 1 gene product, one of three EXT genetic loci involved in hereditary multiple exostoses.  EXT1 protein is a transmembrane glycoprotein glycosyltransferase involved in the biosynthesis of heparan sulfate, and a putative tumor suppressor.
C18051	Menin	Transcription_Repressor_Corepressor	Menin|MEN1	Menin is a product of the MEN1 tumor suppressor gene.  It regulates transcription through direct inhibition of the JUND transcription factor.  Menin interacts with SMAD3 and appears to be required for SMAD3/4-DNA binding at transcriptional regulatory sites.  (from OMIM 131100 and NCI)
C18052	ESX_Protein	Retired_Concepts	ESX Protein	ESX, a novel member of the ETS transcription factor family, is a tumor marker exclusively expressed in epithelial cells.  ESX contains two putative DNA-binding domains: an ETS domain and an A/T hook domain.  (from OMIM 602191 and NCI)
C18053	LY-49	Cell_Surface_Receptor	LY-49|KLRA1|Killer Cell Lectin-Like Receptor Subfamily A|Killer Cell Lectin-Like Receptor Subfamily A Member 1|Killer Cell Lectin-Like Receptor Subfamily A, Member 1|Killer Cell Lectin-Like Receptor, Subfamily A, Member 1|LY49	A surface receptor on NK cells involved in binding to MHC Class I molecules presented on somatic cells as part of a recognition mechanism.
C18054	Notch4_Protein	Cell_Surface_Receptor	Notch4 Protein|Human Homolog 4 of Drosophila Notch4 Protein|NOTCH4|Notch4 / Int3 Gene Product	NOTCH4 Protein is a Drosophila Notch receptor homologue with 29 extracellular EGF-like repeats, three Notch/lin-12 repeats, a transmembrane region, six intracellular cdc10/ankyrin repeats, a polyglutamine domain, and a C-terminal PEST region.  A component of an evolutionarily conserved intercellular signaling mechanism, NOTCH4 is expressed in a variety of tissues and appears to regulate cell fate decisions during embryonic vascular morphogenesis and remodeling.  NOTCH4 and NOTCH1 appear to have partially overlapping roles during embryogenesis in mice.  MMTV INT3 interruption of NOTCH4 produces a gain-of-function truncated product, containing only the transmembrane and intracellular domains, that has profound consequences for mammary gland development and tumorigenesis.  (from OMIM 164951 and NCI)
C18055	Checkpoint_Suppressor-1_Protein	Transcription_Factor	Checkpoint Suppressor 1|CHES1|Forkhead Box Protein N3	Involved in DNA damage-inducible cell cycle arrest, CHES1, a forkhead transcription factor family member, activates a MEC1-independent checkpoint pathway.  (from OMIM 602628 and NCI)
C18056	Angiopoietin-2	Signaling_Protein	Angiopoietin-2|ANGPT2|Ang-2|Ang2|Angiopoietin 2	Encoded by Human ANGPT2 Gene, Angiopoietin 2 is a 496-amino acid 57 kD (precursor) homodimeric secreted protein that contains a fibrinogen-like C-terminus.  ANG2 is nearly 60% identical to ANG1.  A 61 kD homodimeric alternative ANG2(443) product lacks 53 amino acids found in ANG2 encoded by exon B and part of the N-terminal coiled-coil domain.  Like ANG2 and ANG1, secreted ANG2(443) binds endothelial TIE2 receptor tyrosine kinase, but not TIE1.  ANG2(443) partially inhibits ANG2 and ANG1 binding to TIE2.  As an ANG1 and TIE2 antagonist, ANG2 may counteract blood vessel maturation or stability by loosening cell-matrix contacts and inducing endothelial apoptosis.  With VEGF, ANG2 may facilitate endothelial cell migration and proliferation.  In adults, ANGPT2 is only expressed at the sites of vascular remodeling.  (OMIM, Swiss-Prot, and NCI)
C18057	Environmental_Carcinogenesis	Carcinogenesis_Mechanism	Environmental Carcinogenesis|Carcinogenesis, Environmental	Studies to identify or characterize the mechanism of action of non-infectious exogenous agents, conditions, or procedures that initiate, promote, or otherwise contribute to the development of cancer. Although infectious agents are excluded from this definition, extrinsic factors that increase exposure to these agents (e.g., occupation, sexual activity, needle sharing, transfusion) are considered environmental.
C18058	Partial_Remission	Remission	Partial Remission|partial remission	A decrease in the size of a tumor, or in the extent of cancer in the body, in response to treatment. Also called partial response.
C18059	Tobacco_Use	Personal_Behavior	Tobacco Use|Tobacco Consumption	Use of tobacco in any form i.e. smoking, chewing or sniffing.
C18060	Somatic_Mutation	Mutation	Somatic Mutation|somatic mutations	A permanent, transmissible change in the DNA within any somatic cell. If the mutation is inherited by the progeny of the altered cell, it may contribute to aging, cancer or other diseases.
C18061	Blast_Cell_Proliferation	Cell_Proliferation	Blast Cell Proliferation	Multiplication or reproduction by cell division of immature precursor cells that have not achieved a fully differentiated state. (NCI)
C18062	Human_Anti-Mouse_Antibody	Antibody	Human Anti-Mouse Antibody|HAMA	Human antibodies which recognize mouse antibodies.  These often develop in response to treatment with antibodies and limit the effectiveness of the treatment.
C18063	Gray	Radiation_Dose_Unit	Gray|Gy	Gray is the SI derived unit of absorbed radiation dose. One gray is equal to an absorbed dose of one joule per kilogram of matter; one gray equals 100 rads. The unit is named for the British physician L. Harold Gray, an authority on the use of radiation in the treatment of cancer.
C18064	Rad	Radiation_Dose_Unit	Rad	The special unit for radiation absorbed dose, which is the amount of energy from any type of ionizing radiation (e.g., alpha, beta, gamma, neutrons, etc.) deposited in any medium (e.g., water, tissue, air). A dose of one rad means the absorption of 100 ergs (a small but measurable amount of energy) per gram of absorbing tissue (100 rad = 1 gray). (NRC)
C18065	Oncology_Nurse	Registered_Nurse	Oncology Nurse	A nurse who specializes in treating and caring for people who have cancer.
C18066	Supermarkets	Sites_of_Care_Delivery	Supermarket|Supermarkets	A large self-serving retail or wholesale market that sells food and household goods. (WEBS84)
C18067	Inner_City	Geographic_Area	Inner City|Inner Cities	The older and more populated and (usually) poorer central section of a city.
C18068	Radiation_Dose_Unit	Unit_of_Radiation	Radiation Dose Unit	A unit of measurement of the dose of radiation received or absorbed, recorded in Grays (Gy) or Rads
C18069	Church	Sites_of_Care_Delivery	Church	A building for public worship or religious services. (WEBS84)
C18070	Neutron_Radiation	Ionizing_Radiation	Neutron Radiation|Neutron-Radiation|Radiation, Neutron	Radiation of neutrons during radioactive decay.
C18071	Surgeon	Medical_Occupation	Surgeon|surgeon	A doctor who removes or repairs a part of the body by operating on the patient.
C18072	Enzyme_Inhibitor_Protein	Regulatory_Protein	Enzyme Inhibitor Protein	Encoded by Enzyme Inhibitor Genes, Enzyme Inhibitor Proteins block or suppress the catalytic activity of enzymes. (NCI)
C18073	Structural_Protein	Protein_Organized_by_Function	Structural Protein	Proteins whose major function is to give shape and support to tissues, cells, and subcellular structures.
C18074	Training_and_Education	NCI_Administrative_Concepts	Training and Education	To teach theory and hands on experience
C18075	Tissue_Engineering	Bioengineering	Tissue Engineering	application of bioengineering and biomimetic principles for the restoration, repair, replacement, and assembly of functional tissues and organs; application of engineering and life sciences in development of artificial tissues or organs using living cells and different types of biomaterial matrices such as hydrogel, 3 dimensional mesh scaffolds or biodegradable polymers; engineered tissues can restore, maintain, or improve tissue function.
C18076	Bioengineering	Biotechnology|Engineering	Bioengineering|Biomedical Engineering	Bioengineering integrates physical, chemical, or mathematical sciences and engineering principles for treatment and for the study of biology, medicine, behavior, or health.
C18077	Cancer_Risk	Risk	Cancer Risk	The probability that exposure to some agent or substance will adversely transform cells to replicate and form a malignant tumor. (EPA Terminology Reference System)
C18078	Carcinogenesis	Tumorigenesis	Carcinogenesis|Cancer Induction|carcinogenesis	A pathological process in which normal cells are transformed into malignant cancer cells within a primary tumor. Metastasis occurs in advanced stage cancers, whereby cancer cells are released into the bloodstream and attach to sites distinct from the primary tumor, resulting in the formation of secondary tumors.
C18079	Cardiovascular_Pharmacology	Pharmacology	Cardiovascular Pharmacology	Cardiovascular Pharmacology; the study of the effects of drugs upon the heart or circulatory system
C18080	Cell_Growth_Regulation	Cell_Growth_Process	Cell Growth Regulation|Cellular Regulation	Cell growth regulation controls the rate, or the mechanism, of complex coordinated cellular phenomena that promote cell metabolism, cell growth, and cell division.
C18081	Cell_Proliferation	Multicellular_Process	Cell Proliferation|Cellular Proliferation|cell proliferation	An increase in the number of cells as a result of cell growth and cell division.
C18082	Cellular_Oncology	Oncology	Cellular Oncology	The study of the cellular changes associated with the development of neoplastic conditions.
C18083	Chemical_Carcinogenesis	Carcinogenesis_Mechanism	Chemical Carcinogenesis|Carcinogenesis, Chemical	The study of the processes by which normal cells are transformed into cancer cells by chemicals.
C18084	Comparative_Genomic_Analysis	Cytogenetic_Analysis	Comparative Genomic Analysis|CGH|Comparative Genome Hybridization|Comparative Genomic Hybridization	Comparative genomic hybridization (CGH) is a technique that allows the detection of losses and gains in DNA copy number across the entire genome without prior knowledge of specific chromosomal abnormalities.  Comparative genomic hybridization utilizes the hybridization of differentially labeled tumor and reference DNA to generate a map of DNA copy number changes in tumor genomes. Comparative genomic hybridization is an ideal tool for analyzing chromosomal imbalances in archived tumor material and for examining possible correlations between these findings and tumor phenotypes. (from Ried et al. J Mol Med 1997 75:801-14)
C18086	Data_Management	Information_Resources_Management	Data Management
C18087	Developmental_Genetics	Developmental_Biology|Genetics	Developmental Genetics	branch of genetics primarily concerned with how genes control or regulate differentiation and growth.
C18088	Developmental_Neurobiology	Neurosciences	Developmental Neurobiology	study of the development of the brain and nervous system; does not include the psychological or behavioral aspects or nervous system repair; applies to any age group when the nervous system is undergoing development.
C18089	Environmental_Engineering	Engineering	Environmental Engineering
C18090	FOS_Family_Protein	DNA_Binding_Protein	FOS Family Protein|FOS Protein	Nuclear, DNA binding protein; regulates transcription; product of the c-fos proto-oncogene.
C18091	Gel_Electrophoresis	Electrophoresis	Gel Electrophoresis	Gel electrophoresis is a method of separating large molecules (such as DNA fragments or proteins) from a mixture of similar molecules by electrophoretic filtration through a gelatinous matrix.  Subject to an electric field, each molecule in the sample mixture migrates through the matrix at a different rate, depending mainly on electrical charge and size, resulting in spatial separation within the matrix of each molecular species in the sample mixture.  Agarose and acrylamide in a cylindrical tube or slab gel are commonly used media for electrophoresis of proteins and nucleic acids.
C18092	Gene-Environment_Interaction	Gene_Regulation	Gene-Environment Interaction|Gene Environment Interaction	General term referring to the interaction of genetic factors and environmental influences.
C18093	Gene_Mutation	Mutation	Gene Mutation|DNA Alteration|DNA Sequence Alteration|Gene Alteration|Sequence Alteration	A gene mutation is an alteration in the nucleotide sequence of a gene, involving a single or multiple nucleotide substitution, deletion, insertion, or rearrangement that is perpetuated in subsequent divisions of the cell in which it occurs.
C18094	Immunopathology	Pathology	Immunopathology
C18095	Immunoregulation	Immune_Function	Immunoregulation|Immunomodulation	Physiologic control of immune function.  Includes all levels of regulation from gene expression mechanisms, through cell-cell interactions, to organism-wide responses.
C18096	MCF7	Tumor_Cell_Line	MCF7|MCF-7 Cell|MCF7 Cell	cell line derived from a pleural effusion of a human breast adenocarcinoma; has retained several characteristics of differentiated mammary epithelium.
C18097	Molecular_Dynamics	Computer_Modeling	Molecular Dynamics|Molecular Dynamics (MD) Simulation	The science of simulating the motions of a system of particles. (Karplus and Petsko)
C18098	Molecular_Pathology	Pathology	Molecular Pathology	Description of disease and disease processes based upon the underlying protein and genetic defects rather than by a description of morphology.
C18099	Molecular_Psychobiology	Psychobiology	Molecular Psychobiology	biochemical correlates of learning, memory, and other psychological processes.
C18100	Myogenesis	Histogenesis	Myogenesis	Embryonic formation of muscle cells or fibers.
C18101	Special_Population	Population_Group	Special Population|Special Populations	The term special populations refers to those population segments that may experience, or are known to experience, high cancer rates and/or are underserved in terms of cancer prevention and control programs.  Special populations include geographically isolated and other medically underserved populations, blue-collar groups, the elderly, lower-income groups, Alaskan natives, American Indians, Hispanics, Asian- Americans, Blacks, native Hawaiians, and American Samoans.
C18102	Physical_Phenomena_or_Properties	Properties_or_Attributes	Physical Phenomenon or Property|Physical Phenomenon|Physical Process|Physical Property
C18103	Protein_Synthesis	Polymerization	Protein Synthesis	Protein Synthesis is a chemical process by which polypeptide chains are synthesized.
C18104	Protein_Degradation	Post-Translational_Regulation	Protein Degradation|Protein Degradation, Regulatory	Specific degradation of a protein - involving conjugation, transport, oxidation, and proteolysis - involved in signal transduction or cell communication events; not to be confuse with proteolysis, which applies only to peptide bond hydrolysis. (NCI)
C18105	Proteolysis	Hydrolysis	Proteolysis|Protein Cleavage	Proteolysis typically involves hydrolysis of specific peptide bond(s) with formation of smaller polypeptides in a target protein during maturation or modification of functional activity. The process may be catalyzed by proteolytic enzymes, by acids, or by bases.
C18106	Receptor	Ligand_Binding_Protein	Receptor|Receptor Protein|receptor	A molecule inside or on the surface of a cell that binds to a specific substance and causes a specific physiologic effect in the cell.
C18107	Receptor_Mediated_Endocytosis	Endocytosis	Receptor Mediated Endocytosis	A process by which cells internalize molecules or viruses. Receptors on the plasma membrane of the target cell bind to specific cell surface receptorson the endocytic cells, inducing formation of coated pits and endocytic invagination of the plasma membrane.
C18108	Steroid_Hormone_Receptor	Nuclear_Hormone_Receptor_Superfamily	Steroid Hormone Receptor|Steroid Hormones, Receptor|Steroid Hormones, Receptors	Steroid hormone receptors are proteins found in either the cytoplasm or nucleus of eukaryotic cells which bind to and regulate the transcription of DNA under the regulation of steroid hormones. These proteins are the first receptors assigned to the steroid/thyroid/retinoid nuclear receptor superfamily, a group of transcription factors whose activity is regulated by small lipid-soluble molecules.
C18109	Steroid_Metabolism	Metabolic_Process	Steroid Metabolism	Steroid Metabolism consists of diverse biochemical reactions that convert steroid compounds, lipids containing a hydrogenated cyclopentanoperhydrophenanthrene ring system, to metabolic derivatives for assorted uses, such as steroid hormone production and biosynthesis of cell membrane constituents.
C18110	Stoichiometry	Miscellaneous_Chemistry_Terms	Stoichiometry	The relation between the quantities of substances that take part in a reaction or form a compound (typically a ratio of whole integers).
C18111	Structural_Biology	Biology	Structural Biology	The discipline concerned with the three-dimensional configuration of biological molecules and the influence of structure on function.
C18112	Protein_Trafficking	Retired_Concepts	Protein Trafficking|Protein Localization	Mechanisms whereby proteins are sorted or directed to their proper location in the cell.
C18113	Cryo-Electron_Microscopy	Electron_Microscopy	Cryo-Electron Microscopy	Electron microscopy involving an aqueous suspension of a sample which is applied in an extremely thin film to a grid, frozen in liquid nitrogen and maintained in this state by means of a special mount. The imaging of frozen-hydrated molecules and organelles permits the best possible resolution closest to the living state, free of chemical fixatives or stains.
C18114	Representational_Difference_Analysis	DNA_Analysis	Representational Difference Analysis|RDA	PCR-based method for isolating unique sequences; also, used for comparing differences between two complex genomes.
C18115	B-Cell_CLL_Lymphoma-2	Apoptosis_Inhibitor	B-Cell CLL/lymphoma 2|BCL-2 Protein|BCL2	A mitochondrial membrane protein, BCL-2 protein is responsible for blocking apoptosis in normal cells.  Growth factor-stimulated phosphorylation by PKC promotes anti-apoptotic activity of BCL-2 during G2/M.  BCL-2 regulates cell death by controlling mitochondrial membrane permeability.  Cleavage by caspases during apoptosis yields a pro-apoptotic BCL-2 product that causes release of cytochrome C into the cytosol, promoting further caspase activity.  Over expression from translocation t(14;18) of BCL-2 with the immunoglobulin gene region is involved in B-cell lymphomas.  (from OMIM 151430 and NCI)
C18116	Enhancer_Binding_Protein	Sequence-Specific_DNA_Binding_Protein	Enhancer Binding Protein	A protein which binds to an enhancer.  Typically, it binds to a cis enhancer element and modifies the transcriptional activity of the associated gene.
C18117	Surface_Plasmon_Resonance	Physical_Phenomena_or_Properties	Surface Plasmon Resonance	Alteration in light reflectance as a result of binding of molecules to a surface from which total internal reflection is occurring. (on-line medical dictionary)
C18118	Research_Facilities	Funding_Category	Research Facilities	The buildings and equipment used for research.
C18119	Biophysical_Chemistry	Biophysics	Biophysical Chemistry	The science concerned with phenomena that involve biology, physics, and chemistry principles.
C18120	BRCA2_Gene	Regulatory_Gene	BRCA2 Gene|BRCA2|Breast Cancer 2 Gene|Breast Cancer 2, Early Onset Gene|Breast Cancer Type 2 Susceptibility Gene|FANCB|FANCD1|Hereditary Breast Cancer 2	A gene on chromosome 13 that normally helps to suppress cell growth.  A person who inherits an altered version of the BRCA2 gene has a higher risk of getting breast, ovarian, or prostate cancer.
C18121	Tumorigenesis	Oncogenesis	Tumorigenesis|Oncogenesis	The origin or production, or development of cancer, including carcinomas and other malignant neoplasms.
C18122	Chemical_Kinetics	Physical_Chemistry	Chemical Kinetics	The study of rates and mechanisms of chemical reactions and of the factors on which they depend.
C18123	Cryobiology	Biology	Cryobiology	The branch of biology that studies the effects of low temperatures on living tissues or organs or organisms.
C18124	Microdissection	Microtechniques	Microdissection	A laboratory method in which the tissue from a histology slide is dissected under a microscope to procure specific cells or cell populations. (NCI2005)
C18125	DNA_Synthesis	Polymerization	DNA Synthesis	DNA Synthesis is the polymeric linkage of deoxyribose moieties (with adenine, guanine, cytosine, or thymine side chains) by phosphate groups attached to their 5-prime and 3-prime sugar hydroxyls.
C18126	Lipophilicity	Chemical_Properties	Lipophilicity	Lipophilicity represents the affinity of a molecule or a moiety for a lipophilic environment. It is commonly measured by its distribution behavior in a biphasic system, either liquid-liquid or solid-liquid, or thin-layer chromatography system. (from Pure Appl. Chem., 70, 1129-1143 (1998))
C18127	RNA_Transport	Nucleocytoplasmic_Transport	RNA Transport	RNA transport is the translocation of RNA molecules from one cellular location to another, such as transport from the nucleus to the cytoplasm.
C18128	Leukemogenesis	Oncogenesis	Leukemogenesis|Leukemogenesis/Lymphomagenesis	The causation (or induction), development, and progression of a leukaemic disease. (On-line Medical Dictionary)
C18129	Tumor_Initiation	Pathogenesis	Tumor Initiation	The first stage of tumor induction by a carcinogen; subtle alteration of cells by exposure to a carcinogenic agent so that they are likely to form a tumor upon subsequent exposure to a promoting agent. (NCI)
C18130	Neural_Prosthesis	Prosthesis	Neural Prosthesis	Medical devices which interact with or replace parts of the nervous system, eg cochlear implant.
C18131	Neuroimmunology	Immunology	Neuroimmunology	A subdiscipline of immunology with a focus on the nervous system and its interactions with the immune system.
C18132	Parallel_Computing	High_Performance_Computing	Parallel Computing	Model for high performance computing in which a problem is solved by multiple processors working cooperatively and simultaneously.
C18133	Missense_Mutation	Gene_Mutation	Missense Mutation|Mutation, Missense	A mutation in which a base change results in substitution of one amino acid for another.  This change may result in alteration of the protein's activity or stability.
C18134	Transition_Mutation	Base_Pair_Miscoding	Transition Mutation|Mutation, Transition	A point mutation involving substitution of one base-pair for another, i.e., replacement of one purine for another purine or of one pyrimidine for another pyrimidine without change in the purine-pyrimidine orientation.
C18135	Transversion_Mutation	Base_Pair_Miscoding	Transversion Mutation|Mutation, Transversion	A point mutation involving base substitution in which the orientation of purine and pyrimidine is reversed, in contradistinction to transition mutation.
C18136	RT-PCR	Polymerase_Chain_Reaction	RT-PCR|Reverse Transcriptase-Polymerase Chain Reaction	RT-PCR is short for reverse transcriptase-polymerase chain reaction. It is a technique in which an RNA strand is first transcribed into a DNA complement and then subjected to PCR amplification. Transcribing an RNA strand into a DNA complement is termed reverse transcription and is done by the enzyme reverse transcriptase. (from Wikipedia)
C18137	Protein_Renaturation	Protein_Folding	Protein Renaturation	The process of restoring the activity and quaternary structure of a native polypeptide through folding and conformational intermediates.
C18138	Radiolabeled	Miscellaneous_Chemistry_Terms	Radiolabeled|radiolabeled	Any compound that has been joined with a radioactive substance.
C18139	ERG_Gene	ETS_Family_Gene	ERG Gene|ERG|Early Response Gene|v-ETS Erythroblastosis Virus E26 Oncogene Like (Avian) Gene	Human ERG Gene (ETS Family) at 21q22.3 encodes a FLI1-related transcription factor.  ERG1 and ERG2 proteins derive from alternative splicing, polyadenylation, and translation initiation.  ERG2 is a sequence-specific purine-rich DNA-binding phosphoprotein expressed at higher levels in early myeloid cells than in mature lymphoid cells.  It regulates genes required for maintenance or differentiation of early hematopoietic cells.  Many Ewing sarcoma cases display t(21;22) chromosomal translocation involving ERG and EWSR1, resulting in a hybrid protein containing the DNA binding domain of ERG.  (from SWISS-PROT, OMIM, and NCI)
C18140	Yeast_One_Two-Hybrid_System	Expression_Technologies_for_DNA_and_RNA	Yeast One/Two-Hybrid System|Two Hybrid|Yeast One Hybrid System|Yeast Two Hybrid System	Molecular biology technique used to identify interacting proteins in a yeast model.  A protein of interest (the bait) is fused to the DNA-binding domain of a yeast transcription factor (usually GAL4).  (Usually) a cDNA library is fused to the GAL4 activation domain.  The library is then introduced into yeast cells carrying the bait construct.  Functional interaction of the bait with fusion proteins from the library bring together the binding and activation domains of the transcription factor, allowing activation of a reporter gene. (syn: yeast two-hybrid system) (NCI/OSP)
C18141	Computer_Sciences	Technology	Computer Sciences	The study of the structure and dynamics of computational systems using mathematical, logical, and empirical tools.
C18142	Tandem_Mass_Spectrometry	Mass_Spectrometry	Tandem Mass Spectrometry	Mass spectrometers coupled in series.  The targeted compound is selectively ionized, and its characteristic ions are separated from others in the mixture in the first mass spectrometer. The selected primary ions are then decomposed by collision, and from the resulting products the final mass analyzer selects secondary ions characteristic of the targeted compound. Tandem mass spectrometry can achieve specificities and sensitivities equivalent of those of methods such as radioimmunoassay and gas chromatography/mass spectrometry, while performing analyses in much shorter times. (McLafferty, 1981.  Science 214:280-7)
C18143	Gene_Knockout	Molecular_Biology_Techniques	Gene Knockout	Refers to the targeted disruption of a gene within its normal biological context.  Utilized to examine the involvement of a gene in a complex biological process.
C18144	Homologous_Recombination	Recombination	Homologous Recombination	Exchange of like DNA sequences on homologous chromosomes by recombination.
C18145	Informatics	Information_Sciences	Informatics	An occupational discipline which unites information science with computer science.  It is concerned with the development of techniques for the collection and manipulation of data, and the use of such data.
C18146	Intracellular_Transport	Transport_Process	Intracellular Transport	Any subcellular or molecular event, process, or condition involved in translocation of a biological macromolecule from one site or compartment to another, entirely within a cell. (NCI)
C18147	Intracellular_Protein_Transport	Retired_Concepts	Intracellular Protein Transport|Protein Trafficking|Protein Transport	The process whereby cellular proteins are positioned and sequestered in the correct cellular compartment for proper function.  The process of moving proteins from one cellular compartment to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.
C18148	Molecular_Modeling	Computer_Modeling	Molecular Modeling|Nucleic Acid Biochemistry, Molecular Modeling|Protein/Amino Acid Biochemistry, Molecular Modeling	Molecular modeling is the computer simulation of chemical structures or processes; allows for the exploration, visualization, and manipulation of molecular structures and properties.
C18149	High_Performance_Computing	Computer_Sciences	High Performance Computing|High Performance Computing-FCCSET	Refers to a class of evolving technologies that provide leading-edge computational capabilities.  Includes scalable high performance computers, high end graphic systems, and high speed networks.  Used for molecular modeling, genome analysis, and image processing, among others. (from http://www.mhpcc.edu/)
C18150	Sodium_Dodecylsulfate-Polyacrylamide_Gel_Electrophoresis	Polyacrylamide_Gel_Electrophoresis	Sodium Dodecylsulfate-Polyacrylamide Gel Electrophoresis|SDS-PAGE	Sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis is a technique for estimating molecular weights of polypeptides, and uses SDS, a detergent that dissociates and unfolds oligomeric proteins into its subunits. The SDS binds to the polypeptides to form complexes with fairly constant charge to mass ratios. The electrophoretic migration rate through a gel is therefore determined only by the size of the complexes.(NCI2005)
C18151	Diaphanography	Imaging_Technique	Diaphanography	Passage of light through body tissues or cavities for examination of internal structures.
C18152	Threonine-Tyrosine_Protein_Kinase	Protein_Kinase	Threonine/Tyrosine Protein Kinase|MAP/ERK Kinase	Class of enzymes that phosphorylate protein substrates at tyrosine or threonine residues.
C18153	Caspase	Cysteine_Proteinase	Caspase|Caspases|Cell-Death Protease|ICE-like protease|ICE-like proteases	Caspases are a family of intracellular cysteine proteinases involved in inflammation and apoptosis.  These enzymes appear to be involved in the initial signaling events, as well as the downstream proteolytic cleavages, that result in apoptotic cell death.  They are specific for aspartic acid at the P1 position and are divided into two classes based on the lengths of their N-terminal pro-domains.  Caspases-1, -2, -4, -5, -8, and -10 have long pro-domains; caspases-3, -6, -7, and -9 have short pro-domains.  (from Science 1998. 281:1312 and Br Med Bull 1997. 53:478)
C18154	Chromosome_Painting	Fluorescence_in_situ_Hybridization	Chromosome Painting	Refers to the hybridization of fluorescently labeled, chromosome-specific, composite probe pools to cytological preparations. It allows the visualization of individual chromosomes in metaphase or interphase cells and the identification of both numerical and structural chromosomal aberrations with high sensitivity and specificity.  Chromosome painting can be applied to cross-species comparisons as well as to the study of chromosomal rearrangements. The simultaneous hybridization of multiple chromosome painting probes, each tagged with a specific fluorochrome or fluorochrome combination, has resulted in the differential color display of chromosomes, i.e. spectral or color karyotyping. (From Ried  et al 1998 Hum Mol Genet 7:1619)
C18155	Expressed_Sequence_Tag	Sequence_Tagged_Site	Expressed Sequence Tag|EST	Expressed Sequence Tags (ESTs) are essentially Sequence Tagged Sites (EST) that are represented in mRNA.  They are derived as 300-500 bp single-pass mRNA sequence reads from many of the genes expressed in a given tissue and/or at a given developmental stage. They represent a snapshot of gene expression in a given place or time.
C18156	Graft-vs-Leukemia_Effect	Immune_Response	Graft-vs-Leukemia Effect|GVL	an advantageous side-effect of a graft-vs-host reaction in which a leukemia patient is first irradiated to kill residual leukemic cells and is then given a bone marrow graft to replenish the immune system.  If cytotoxic T cells are not depleted from the bone marrow graft, these alloreactive T cells can attack the host's cells (graft-vs-host reaction) but can also attack the host's residual leukemic cells, thereby assisting in preventing recurrence of disease.
C18157	Distance_Learning	Education	Distance Learning	Refers to the process by which students and teachers at different sites carry out learning and instruction via cable connection, conventional phone lines, or computer networks.
C18158	DNA_Microarray_Chip	Microarray	DNA Microarray Chip|Chip|DNA Chip|DNA Microarray	A DNA chip is an orderly array of DNA samples affixed to a support.  Using robots thousands of samples can be arrayed on a single chip.  The chip is used in various types of hybridization experiments.
C18159	Journalism	Social_Sciences	Journalism	Journalism is the practice of collecting and publishing information regarding current events. (from Wikipedia)
C18160	Manuscripts	Document_Type	Manuscript|Manuscripts	Unpublished or draft copies of scientific articles and book chapters.
C18162	eIF2B	Protein_or_Riboprotein_Complex	eIF2B|eIF-2B	EIF2B is a heteropentameric complex (alpha, beta, gamma, delta, and epsilon subunits) essential for protein synthesis that catalyzes GDP/GTP exchange of its Eukaryotic Initiation Factor 2 substrate (restores GTP bound EIF2). For EIF2 to perform additional rounds of initiation, it must be recycled by GDP/GTP exchange. Thus, EIF2B sustains translation. EIF2B-epsilon contains a putative nucleotide-binding domain that may be involved in nucleotide exchange.  EIF2B defects cause VWM. (NCI)
C18163	Glandular_Kallikrein-2_Precursor	Human_Glandular_Kallikrein	Glandular Kallikrein 2 Precursor|EC 3.4.21.35|Glandular Kallikrein 2|KLK2|Kallikrein 2|Kallikrein 2, Prostatic|Kallikrein, Glandular|Kallikrein, Prostatic|Prostatic Kallikrein 2|Tissue Kallikrein|hGK-1|hK2	Glandular Kallikrein 2 isoforms 1 (261-aa, 28.7-kD prepropeptide), 2 (PGK-10A, 222-aa), 3 (164-aa) are encoded by human KLK2 Gene (Kallikrein Family). The mature serine protease is 237 amino acids. Glandular kallikreins comprise specific proteases involved in processing active peptides. KLK2 exhibits 66% and 73% homology with KLK1 and APS. Glandular kallikreins release vasoactive peptides from kininogen; the kininogenase activity of different kallikreins is highly variable. Kallikrein 2 cleaves kininogen Met-X, Arg-X, or Leu-X bonds to release lys-bradykinin (kallidin) involved in vasodilation and smooth muscle contraction. The physiologic role of specific kallikreins is often unrelated to the kininogenase activity. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C18164	Matrix_Metalloproteinase	Metalloproteinase	Matrix Metalloproteinase|matrix metalloproteinase	Matrix metalloproteinases are Zn(2+)-binding endopeptidases that degrade components of the extracellular matrix. These enzymes are implicated in tissue remodeling processes, wound healing, angiogenesis, and tumor invasion. Matrix metalloproteinases have been associated with the development of advanced-stage cancer via their role in tumor progression, invasion, and metastasis.
C18165	Neuregulin-1_Protein	Neuregulin	Neuregulin 1|Acetylcholine Receptor Inducing Activity|Breast Cancer Cell Differentiation Factor P45|Glial Growth Factor|Heregulin|NRG1|NRG1 Gene Product|Neu Differentiation Factor|Neuregulin-1|Sensory And Motor Neuron-Derived Factor	Neuregulin-1 was first cloned as "heregulin" and "neu differentiation factor" and was initially thought to be a ligand for ErbB2, which is overexpressed in about 25% of women with breast cancer. Neuregulin-1 has also been studied as the "glial growth factor," which acts as a Schwann cell mitogen, and as "ARIA" (acetylcholine receptor inducing activity), a regulator of the expression of acetylcholine receptors.
C18166	RGS_Family_Protein	Signaling_Protein	RGS Family Protein|RGS Protein	RGS family proteins activate GTPase and regulate G protein signaling by stimulating the inactivation of heterotrimeric G proteins. RGS family proteins are responsible for the rapid turnoff of G protein-coupled receptor signaling pathways. There are indications that a subset of RGS proteins regulate specific G protein-coupled receptor pathways.
C18167	B-Cell_CLL_Lymphoma-3	Transcription_Factor	B-Cell CLL/Lymphoma 3|B-Cell Lymphoma 3-Encoded Protein|BCL-3 Protein|BCL3|BCL4|D19S38	A possible transcriptional activating factor, BCL3 is activated by phosphorylation and functions as an IKB specific for the p50 subunit of NFKB, inhibiting its translocation to the nucleus.  BCL3 confers a survival advantage to T-cells, possibly by promoting the expression of genes repressed by NFKB members.  Translocation t(14;19)(q32;q13.1), involving BCL3 and immunoglobulin gene regions, is associated with B-CLL.  (from OMIM 109560 and NCI)
C18168	ID2_Protein	Cell_Cycle_Protein	ID2 Protein|DNA-Binding Protein Inhibitor ID-2|ID2|Inhibitor of DNA Binding 2|Inhibitor of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein|Inhibitor of Differentiation 2	A member of the "ID" subfamily, ID2 promotes cell cycle progression by inhibiting RB, p107, and p130.  By increasing ID2 expression, MYC overrides RB suppression of ID2 action.  Since ID2 lacks a DNA-binding domain it must work through dimerization with other HLH transcription factors.  (from SWISS-PROT Q02363, OMIM 600386, and NCI)
C18169	Spleen_Tyrosine_Kinase	syk_Family_Tyrosine_Kinase	Spleen Tyrosine Kinase|2.7.1.112|PTK72|PTK72 Protein|SYK|Tyrosine-Protein Kinase SYK	Related to B cell activation, PTK72 is a tyrosine kinase that becomes tyrosine phosphorylated and activated soon after anti-Ig stimulation of B cells.  It is found associated with the mIg receptor complex.  Unlike the membrane-bound Src-family tyrosine kinases, PTK72 is primarily present as a soluble cytosolic protein.  It is probably the product of the syk gene and is highly related to the ZAP-70 protein associated with T cell activation.
C18170	MAF_Protein	MAF_Family_Protein	MAF Protein|MAF	MAF Protein contains a leucine zipper motif similar to that in many bZIP DNA binding proteins, including FOS, JUN, and MYC oncogenes.  Members of the MAF family appear to play important roles in the regulation of differentiation.  (from OMIM 177075 and NCI)
C18171	GLI_Protein	GLI_Family_Protein	GLI Protein|GLI|GLI1|GLI1 Protein|Glioma Associated Oncogene Homolog 1 Protein	The GLI1 Protein, a Kruppel family protein, is homologous to Drosophila Cubitus interruptus and contains five DNA-binding zinc finger repeats, implicated in transduction of the SHH signal; an endodermal signal that controls hindgut patterning and lung growth.  The GLI1 gene is found amplified in a malignant glioma.  (from OMIM 165220 and NCI)
C18172	Nuclear_Receptor_Coactivator-3	Transcription_Coactivator	Nuclear Receptor Coactivator 3|ACTR|AIB1|Amplified in Breast Cancer|Amplified in Breast Cancer 1 Protein|NCOA3|P/CIP|RAC3|Receptor-Associated Coactivator 3|TRAM-1|Thyroid Hormone Receptor Activator Molecule	NCOA3 is a nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in hormone-dependent fashion. NCOA3 recruits 2 other nuclear factors, CBP and PCAF, and thus plays a central role in creating a multisubunit coactivator complex. (LocusLink)
C18173	TERT_Gene	Telomere_Maintenance_Gene	TERT Gene|EST2|TCS1|TERT|TRT|Telomerase Reverse Transcriptase Catalytic Subunit Gene|Telomerase Reverse Transcriptase Gene|hEST2|hTERT|hTERT Gene|hTRT	This gene at 5p15.33 consists of 16 exons and 15 introns, and encodes TERT that mediates reverse transcriptase-like catalysis and is limiting for telomerase function in telomere maintenance. TERT also delays cell cycle exit in cardiac muscle, induces hypertrophy in postmitotic cells, and promotes cardiac myocyte survival. The TERT promoter is GC-rich, lacks TATA and CAAT boxes, but contains binding sites for MYC oncoprotein and other transcription factors that may be involved in its regulation. The TERT promoter is inactive in normal and in transformed pre-immortal cells but is activated with cell immortalization. This gene is expressed at high levels in primary tumors, cancer cell lines, and telomerase-positive tissues, but is undetectable in telomerase-negative cell lines and differentiated telomerase-negative tissues. Telomerase activity is an independent prognostic factor in neuroblastoma.
C18174	TRAIL_Receptor-1	TNF_Receptor_Family_Protein	Tumor Necrosis Factor Receptor Superfamily, Member 10A|Cytotoxic TRAIL Receptor|Death Receptor 4|TNF-Related Apoptosis Inducing Ligand Receptor 1|TNFRSF10A|TRAIL Receptor 1	A member of the TNF family.  TRAIL Receptor 1 (DR4) contains two cysteine-rich pseudorepeats resembling regions in TNFR1, DR3, and FAS, a transmembrane domain, and an intracellular death domain.  Unlike FAS, TNFR1, and DR3, DR4 does not use FADD to transmit the death signal, suggesting the use of a distinct signaling machinery.  (from OMIM 603611 and NCI)
C18175	Neuregulin-2_Protein	Neuregulin	Neuregulin 2|DON-1|DON1|Divergent of Neuregulin 1|NRG-2|NRG2|NTAK|Neural- and Thymus-Derived Activator for ErbB Kinases|Neuregulin-2	Encoded by human NRG2 Gene (NRG Family), variant type I membrane or soluble growth factor Neuregulin 2 proteins (422-858-aa, 91.7-kD precursor) contain an N-terminal domain, an Ig-C2 loop, an EGF-like domain, a transmembrane sequence, and a large cytoplasmic tail with potential N-linked and O-linked glycosylation sites. The membrane-bound form seems to be inactive and the cytoplasmic domain may regulate trafficking and proteolytic processing (by dimerization). Like Neuregulin 1, Neuregulin 2 binds to transmembrane ERBB3 and ERBB4 tyrosine kinase receptors, recruits ERBB1 and ERBB2 coreceptors, and induces receptor activation. ERBB receptor binding may involve entirely the EGF-like domain. Found primarily in the nervous system, Neuregulin 2 induces growth and differentiation of epithelial, neuronal, glial, and other cell types. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C18176	Hamartin	Ligand_Binding_Protein	Hamartin|TSC1	A product of the tumor suppressor gene TSC1.  Hamartin and tuberin (TSC2) associate physically and may function together in the insulin-signaling pathway.  Hamartin may stabilize ubiquitinated tuberin, which contributes to inhibition of cell growth.  Loss of hamartin leads to loss of cell adhesion and initiates the development of TSC hamartomas.  (from OMIM 605284 and NCI)
C18177	Axin-1_Protein	Signaling_Protein	Axin 1|AXIN1|Axin|Axis Inhibitor 1	Product of the Axin1 Gene.  Triggers degradation of beta-catenin and helps establish dorsal-ventral patterning during embryogenesis.
C18178	TRAIL_Receptor-2	TNF_Receptor_Family_Protein	Tumor Necrosis Factor Receptor Superfamily, Member 10B|Apoptosis Inducing Protein TRICK2A/2B|Cytotoxic TRAIL Receptor-2|DR5|Death Receptor 5|Fas-Like Protein Precursor|P53-Regulated DNA Damage-Inducible Cell Death Receptor (Killer)|TNFRSF10B|TRAIL Receptor 2|TRAIL-R2|TRAILR2|Tumor Necrosis Factor Receptor-Like Protein ZTNFR9	Receptor for Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)
C18179	Survivin	IAP_Family_Protein	Survivin|API4|Apoptosis Inhibitor 4|Apoptosis Inhibitor Survivin|BIRC5|Baculoviral IAP Repeat-Containing 5 (Survivin)|Baculoviral IAP Repeat-Containing Protein 5|EPR-1|IAP4	Survivin is an apoptosis inhibitor that is expressed during the G2/M phase of the cell cycle. It is abundantly expressed in various human cancers but undetectable in normal differentiated tissues. Survivin associates with the microtubules of the mitotic spindle and any disruption results in the loss of apoptosis activity. It is physically associated with cyclin-dependent kinase p34(cdc2) on the mitotic apparatus, and is phosphorylated on Thr(34) by p34(cdc2)-cyclin B1 in vitro and in vivo. Therefore, survivin phosphorylation on Thr(34) may be required to preserve cell viability at cell division. Manipulation of this pathway may facilitate the elimination of cancer cells at mitosis. (from LocusLink)
C18180	Neuregulin-3_Protein	Neuregulin	Neuregulin 3|NRG3|Neuregulin-3	Encoded by human NRG3 Gene (NRG Family), conserved 720-aa Neuregulin 3 is a brain and testis soluble growth and differentiation factor, and a type I membrane protein containing 2 hydrophobic segments similar to the transmembrane domain and internal signal sequence in NRG1. NRG3 also contains an N-Ala/Gly-rich segment, an EGF motif, and a mucin-like Ser/Thr-rich region with sites for O-linked glycosylation. Membrane-bound NRG3 may be inactive. Preceded by extensive glycosylation, external proteolytic cleavage close to the plasma membrane may involve dimerization of the intracellular domain. A ligand for ERBB4 receptor tyrosine kinase (likely via the EGF-like domain), NRG3 does not bind to ERBB2, ERBB3, or EGF receptor. The ERBB4 binding sites of NRG1 and NRG3 may overlap. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C18181	PTEN_Tyrosine_Phosphatase	Signaling_Protein	PTEN Tyrosine Phosphatase|Mutated in Multiple Advanced Cancers 1|PTEN	PTEN contains a tyrosine phosphatase domain and a region of homology to auxilin and tensin (which interacts with actin).  PTEN inhibits insulin-induced IRS1 phosphorylation and IRS1/GRB2/SOS complex formation and influences the PI3 kinase/AKT pathway in FAS-induced apoptosis.  PTEN blocks cell cycle progression in G1 through negative regulation of PI3 kinase/AKT signaling to cyclin-dependent kinase inhibitor p27(KIP1), increasing p27, decreasing cyclin D1, and inhibiting AKT phosphorylation.  PTEN may regulate cell interactions with the extracellular matrix and effect cell migration, integrin-mediated cell spreading, and formation of focal adhesions.  PTEN reduces tyrosine phosphorylation of FAK.  The PTEN gene is transactivated by p53.  (from OMIM 601728 and NCI)
C18182	Caspase-8	Caspase	Caspase-8|CASP8|CASP8 Protein|Caspase 8|Caspase-8/Flice|FADD-Like ICE|FADD-homologous ICE/CED3-Like Protease|FLICE|MACH|MCH5	A member of the ICE cysteine-protease family.  A downstream factor in apoptosis induced by TNFR and FAS
C18183	Serine-Threonine_Protein_Kinase-11	Serine-Threonine_Protein_Kinase	Serine/Threonine Protein Kinase 11|LKB1|STK11|STK11/LKB1 Protein	LKB1, a serine/threonine kinase, is thought to act in the VEGF signaling pathway.  LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways.  LKB1 protein translocates to mitochondria during apoptosis.  (from OMIM 602216 and NCI)
C18184	Histone_Acetyltransferase-1	Histone_Acetylase	Histone Acetyltransferase 1|HAT1|HAT1 Acetyltransferase	Histone acetylation, particularly of histone H4, has been proposed to play an important role in replication-dependent nucleosome assembly. The HAT1 protein contains D, A, and B motifs, which are present in many N-acetyltransferases, including those that acetylate substrates other than histones. The HAT1 holoenzyme consists of 2 subunits: the catalytic 46-kD HAT1 and the accessory p46 (RBBP7). The p46 subunit stimulated the activity of HAT1 and bound to core histones. The HAT1 holoenzyme acetylated newly synthesized but not nucleosomal histone H4 at lys5 and lys12, and, to a lesser extent, histone H2A at lys5. HAT1 and p46 polypeptides are located in the nucleus of S-phase cells. (from LocusLink)
C18185	TAF-172	SWI2-SNF2_Family_Protein	TAF-172|BTAF1|MOT1 Homolog|TAF(II)170|TAFII170|TATA Box-Binding Protein-Associated Factor RNA Polymerase II 170-kDa|TBP-Associated Factor-172	Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP; MIM 600075) and TBP-associated factors, or TAFs (e.g., TAF2B; MIM 604912), in 2 distinct complexes, TFIID and B-TFIID. The TFIID complex is composed of TBP and more than 8 TAFs. However, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170, also called TAF172, and has DNA-dependent ATPase activity.(LocusLink, as supplied by OMIM)
C18186	Hepatocyte_Growth_Factor_Receptor	Receptor_Tyrosine_Kinase	Hepatocyte Growth Factor Receptor|C-MET|HGF-SF Receptor|HGFR|MET Gene Product	The MET proto-oncogene encodes hepatocyte growth factor receptor, a cell surface receptor-like tyrosine kinase comprised of disulfide-linked 50 kD (alpha) and 145 kD (beta) subunits.  In the fully processed c-MET product, the alpha subunit is extracellular, and the beta subunit has extracellular, transmembrane, and tyrosine kinase domains, as well as sites of tyrosine phosphorylation.  The beta subunit of the c-MET proto-oncogene product is the cell surface receptor for hepatocyte growth factor.  c-MET is related to the insulin receptor and ABL oncogene.  (from OMIM 164860 and NCI)
C18187	DDX6_Protein	RNA_Helicase	DDX6 Protein|DDX6|DEAD Box Protein 6|DEAD/H Box Protein 6|Probable ATP-DEPENDENT RNA HELICASE P54|Proliferation Associated Nuclear Antigen P68	A putative RNA helicase
C18188	Stereochemistry	Chemistry	Stereochemistry	Stereochemistry is the study of how the properties of a compound are affected by the spatial positions of groups within its molecules. Stereochemistry is also concerned with determining the structure of stereoisomers. (General Chemistry Glossary; http://antoine.frostburg.edu/chem/senese/101/glossary.shtml)
C18189	Pathology	Medical_Specialty	Pathology|PATH	The medical science, and specialty practice, concerned with all aspects of disease, but with special reference to the essential nature, causes, and development of abnormal conditions, as well as the structural and functional changes that result from the disease processes. Informally used to mean the result of such an examination.
C18190	Histopathology	Histology|Pathology	Histopathology	The microscopic study of characteristic tissue abnormalities by employing various cytochemical and immunocytochemical stains.
C18191	Computer_Analysis	Computer_Sciences	Computer Analysis	Data processing largely performed by automatic means.
C18192	Plastic_Surgery	Surgical_Specialty	Plastic Surgery	The branch of surgery concerned with restoration, reconstruction, or improvement of defective, damaged, or missing structures.
C18193	Immunological_Diagnostic_Methods	Immunologic_Techniques	Immunological Diagnostic Methods|diagnostic methods, immunological	Methods used to identify disease using laboratory techniques involving interaction of antigens with specific antibodies.(NCI2005)
C18194	Molecular_Diagnostic_Methods	Diagnostic_Procedure	Molecular Diagnostic Methods	Methods for diagnosis or monitoring of disease predisposition by translation and validation of molecular discoveries in medicine into the clinical diagnostic setting. (NCI2005)
C18195	Medical_Genetics_Board_Certification	Board_Certification	Medical Genetics Board Certification
C18196	Genetic_Counseling_Board_Certification	Board_Certification	Genetic Counseling Board Certification
C18197	Clinical_Genetics_Board_Certification	Board_Certification	Clinical Genetics Board Certification
C18198	Clinical_Biochemical_Genetics_Board_Certification	Clinical_Genetics_Board_Certification|Medical_Genetics_Board_Certification	Clinical Biochemical Genetics Board Certification
C18199	Clinical_Molecular_Genetics_Board_Certification	Clinical_Genetics_Board_Certification|Medical_Genetics_Board_Certification	Clinical Molecular Genetics Board Certification
C18200	Clinical_Cytogenetics_Board_Certification	Clinical_Genetics_Board_Certification	Clinical Cytogenetics Board Certification
C18201	Antiangiogenesis	Retired_Concepts	Antiangiogenesis
C18202	Biopsy_Specimen	Specimen	Biopsy Specimen|Biopsy Sample|biopsy specimen	A specimen obtained by biopsy, which is a process of removing tissue from living patients for diagnostic examination.
C18203	Brief_Pain_Inventory	Pain_Assessment_Tool	Brief Pain Inventory	A brief, simple, and easy to use tool for the assessment of pain in both clinical and research settings. The BPI uses simple numeric rating scales from 0 to10 that are easy to understand and easy to translate into other languages. On the BPI, mild pain is defined as a worst pain score of 1 - 4, moderate pain is defined as a worst pain score of 5 - 6, and severe pain is defined as a worst pain score of 7-10.
C18204	Compression_Bandage	Medical_Device	Compression Bandage|compression bandage	A bandage designed to provide pressure to a particular area.
C18205	Clinical_Trials_Cooperative_Group	Professional_Organization_or_Group	Clinical Trials Cooperative Group|Clinical Cooperative Groups|Clinical Trial Groups|Clinical Trials Cooperative Groups|Cooperative Group|Cooperative Groups|cooperative group	A group of physicians, hospitals, or both formed to treat a large number of persons in the same way so that a new treatment can be evaluated quickly. Clinical trials of new cancer treatments often require many more people than a single physician or hospital can care for.
C18206	Distant_Metastasis	Metastasis	Distant Metastasis|Distant Cancer|distant cancer	A biological process that involves the transfer and growth of cancer cells from the site of the primary tumor. Relocation of malignant cells during metastasis can be restricted to movement within a specific tissue/organ or may entail migration to a distal locus within the body. This phenotype is a characteristic of all malignant tumors.
C18208	Liposome	Drug_Delivery_System	Liposome|Liposomal	A drug preparation that contains the active drug in very tiny fat particles. This fat-encapsulated drug is absorbed better, and its distribution to the tumor site is improved.
C18209	Lymph_Node_Drainage	Organismal_Process	Lymph Node Drainage|lymph node drainage	The flow of fluids and lymphocytes in the lymphatic vessels, which are concentrated from tissue fluids, into a particular lymph node. Once the fluid has transited the lymph node, it is returned to the blood via the lymphatic system.
C18210	Lymph_Node_Mapping	Test|Test_Generic	Lymph Node Mapping|lymph node mapping	Lymph Node mapping, also known as sentinel lymph node (SLN) mapping is a procedure in which a radioactive tracer and a blue dye is injected around the tumor site. These two substances travel from the tumor and drain into the sentinel, or main, lymph node. Together they provide a marker for the location and presence of a sentinel lymph node, allowing discovery of minute metastases areas. (NCI2005)
C18211	Protein_Overexpression	Protein_Expression	Protein Overexpression|Overexpression|overexpress	An excess of a particular protein on the surface of a cell.
C18212	Partial_Response	Clinical_Course_of_Disease	Partial Response|PR|partial response	A decrease in the size of a tumor, or in the extent of cancer in the body, in response to treatment.
C18213	Stable_Disease	Clinical_Course_of_Disease	Stable Disease|SD|stable disease	Cancer that is neither decreasing nor increasing in extent or severity.
C18214	Whitmore-Jewett_Staging_System	Staging_System	Whitmore-Jewett Staging System|ABCD rating|Jewett staging system|Whitmore-Jewett staging system	A staging system for prostate cancer that uses ABCD.  A and B refer to cancer that is confined to the prostate. C refers to cancer that has grown out of the prostate but has not spread to lymph nodes or other places in the body. D refers to cancer that has spread to lymph nodes or to other places in the body.
C18215	Chemosensitivity_Assay	Test|Test_Generic	Chemosensitivity Assay|Chemosensitivity Testing|chemosensitivity assay	A laboratory test to analyze the responsiveness of a tumor to a specific drug.
C18216	Transmission_Electron_Microscopy	Electron_Microscopy	Transmission Electron Microscopy|Microscopy, Electron, Transmission|TEM	Electron microscopy in which the electron beam passes through the sample.
C18217	Potential_Energy	Chemical_Properties|Physical_Phenomena_or_Properties	Potential Energy	Stored energy.  In biological systems energy is stored in the structure of molecules and is released through metabolism.
C18218	Free_Energy	Chemical_Properties|Physical_Phenomena_or_Properties	Free Energy	"A thermodynamic term used to describe the energy that may be extracted from a system at constant temperature and pressure. In biological systems the most important relationship is: _G = RTln(Keq), where Keq is an equilibrium constant.  "
C18219	Molecular_Interaction	Biophysical_Process	Molecular Interaction|Binding	A Molecular Interaction involves temporary non-covalent binding of two or more molecules as a result of intermolecular physical forces and often involves spatial complementarity between the interacting objects.
C18220	Human_Biology	Vertebrate_Biology	Human Biology
C18221	Ethanol_Metabolism	Detoxification	Ethanol Metabolism	Ethanol Metabolism consists of various biochemical detoxification reactions that convert ethanol to metabolic derivatives for elimination from the body.
C18222	Pharmacology_and_Toxicology	Pharmacology	Pharmacology and Toxicology	The science concerned with drugs together with the science concerned with the detection, chemical composition, and pharmacologic action of toxic substances or poisons and the treatment and prevention of toxic manifestations.
C18223	Therapeutic_Index	Attributes_of_Chemicals	Therapeutic Index	The difference between the concentration at which clinical benefit (cancer cell killing) is seen and that at which toxicity to normal tissues occurs.  The larger the therapeutic index the safer a drug is.
C18224	Endocrine_Physiology	Physiology	Endocrine Physiology	Study of the functions and activities of the endocrine system as a whole or of any of its parts.
C18225	Phenocopy	Miscellaneous_Molecular_Biology_Terms	Phenocopy	An environmentally produced phenotype simulating the effect of a particular genotype.
C18226	Disease_Outcome	Outcome	Disease Outcome
C18227	Media_Campaign	Education_and_Outreach	Media Campaign	Public communication via television, radio, newspapers, pamphlets, telephone, and other media to influence health or social behaviors.
C18228	Treatment_Factors	Diagnostic_or_Prognostic_Factor	Treatment Factor
C18229	Health_Information_System	Computer_System	Health Information System
C18230	Social_Group	Population_Group	Social Group	Social Group; people sharing some social relationship.
C18231	Communication_Methods	Information_and_Communication_Theory	Communication Methods
C18232	Glossary	Document_Type	Glossary|Glossaries	Glossary; an alphabetical list of technical terms in some specialized field of knowledge; usually published as an appendix to a text on that field.
C18233	Program_Announcements	Funding_Opportunities	Program Announcement|NIH Program Announcements|PA|Program Announcements|Program Announcements, NIH	A formal statement that describes and gives notice to the grantee community of the existence of an NIH-wide or individual Institute/Center extramural research activity/interest or announces the initiation of a new or modified activity/interest or mechanism of support and invites applications for grant or cooperative agreement support. (from The NCI Grants Process: Glossary)
C18234	Geographic_Distribution	Properties_or_Attributes	Geographic Distribution
C18235	Time_Series_Analysis	Statistical_Methods	Time Series Analysis	There are two main goals of time series analysis: (a) identifying the nature of the phenomenon represented by the sequence of observations, and (b) forecasting (predicting future values of the time series variable). (from http://www.statsoftinc.com/textbook/sttimser.html)
C18236	Ethnic_Origin	Retired_Concepts	Ethnic Origin|Ethnic Group|Ethnic Origins	The concept of ethnic origin is an attempt to classify people, not according to their current ethnicity, but according to where their ancestors came from.  Ethnic origin has become a popular classification in statistics, where the concept of race has been largely discarded. (from Wikipedia)
C18237	Alaska_Native	American_Indian_or_Alaska_Native	Alaska Native|Alaska Indian|Alaska Indians|Alaska Natives	Alaska Native - a person having origins in any indigenous people of Alaska and their descendants and who maintains tribal affiliation, or community or cultural attachment. The concept refers to population subgroups such as Eskimos, Aleuts, Inupiat, Yupik, Alutiiq, Egegik,and Pribilovian, Alaskan Athabascan, Tlingit, and Haida. The concept refers also to individuals who classify themselves as described below.
C18238	Economically_Deprived	Underserved_Population	Economically Deprived Population|Economically Deprived
C18239	G_Protein-Coupled_Receptor	Cell_Surface_Receptor	G Protein-Coupled Receptor|G Protein-Complex Receptor|G Protein-Complex Receptors|G-Protein Coupled Receptor|GPCR	Cell surface receptors that are coupled to G-proteins (GTP-binding protein).  G-protein coupled receptors are thought to have seven membrane spanning domains and have been divided into 2 subclasses: those in which the binding site is in the extracellular domain for example receptors for glycoprotein hormones, such as thyroid stimulating hormone (TSH) and follicle-stimulating hormone (FSH) and those in which the ligand binding site is likely to be in the plane of the 7 transmembrane domains for example rhodopsin and receptors for small neurotransmitters and hormones for example muscarinic acetylcholine receptor. (On-line Medical Dictionary)
C18240	Academia	Business_Rules	Academia	College, University or institute with scholastic life or environment.
C18241	General_Population	Population_Group	General Population|General Public
C18242	Column_Chromatography	Chromatography	Column Chromatography	A process used for separating mixtures by virtue of differences in absorbency.  It involves stationary and mobile phases.  The stationary phase was packed in a column with materials that can be of any partitioning capability, adsorption, ion exchange, or affinity.  The mobile phase (either liquid or gas) is the mixture that required to be separated.
C18243	Regression	Clinical_Course_of_Disease	Regression|regression	A decrease in the size of a tumor or in the extent of cancer in the body.
C18244	Environmental_Risk_Factor	Risk_Factor	Environmental Risk Factor	Health hazards at home, in the work place, or in nature (e.g., infectious agents, irritants, respiratory fibrotic agents, asphyxiants, allergens, metabolic poisons, physical agents, mutagens, teratogens, and carcinogens). (Winett et al: Health Psychology and Public Health)
C18245	Organization_Charts	Document_Type	Organization Charts|Organizational Structure	The hierarchy of groups and sub-groups within an organization.
C18246	Remission	Clinical_Course_of_Disease	Remission|RMSN|remission	A decrease in or disappearance of signs and symptoms of cancer.  In partial remission, some, but not all, signs and symptoms of cancer have disappeared.  In complete remission, all signs and symptoms of cancer have disappeared, although there still may be cancer in the body.
C18247	Cancer_Genetics	Cancer_Biology	Cancer Genetics|Genetics of Cancer	Cancer Genetics; the science of heredity and the biological process of transmission of characteristics from progenitor to offspring, especially concerning a heritable predisposition to cancer susceptibility.
C18248	Oncogene_MET	C-MET_Gene	Oncogene MET|Activated Hepatocyte Growth Factor Receptor Gene|Hepatocyte Growth Factor Receptor Gene|MET|Oncogene HGFR	The MET oncogene is derived from a chromosomal rearrangement involving the MET and TPR (translocated promoter region) loci and is a cloned gene for Hereditary Papillary Renal Carcinoma.  The MET proto-oncogene encodes hepatocyte growth factor receptor, a disulfide-linked two subunit receptor protein tyrosine kinase.  The human gene is located at 7q31.
C18249	CDH1_Gene	Cell_Adhesion_Molecule_Gene	CDH1 Gene|Arc-1|CDH1|CDHE|Cadherin 1, Type 1, E-Cadherin (Epithelial) Gene|ECAD|LCAM|UVO	A cloned gene for Familial Gastric Cancer, human CDH1 Gene (CDH Family) at 16q22.1 encodes E-Cadherin, the main epithelia (non-neural) homodimeric Ca2+-dependent homophilic cell-cell adhesion glycoprotein. Similar to other cadherins, CDH1 has sixteen exons spanning 100 kb. An invasion suppressor type I membrane protein ligand for integrin Alpha-E/Beta-7, E-cadherin is comprised of five extracellular Ig-like cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail. The ectodomain mediates bacterial adhesion to mammalian cells; the cytoplasmic domain is required for internalization. As a major event in cancer proliferation, invasion, and metastasis due to dysfunction of cell-cell adhesion, E-cadherin down regulation correlates with invasive potential and poor carcinoma prognosis. (from LocusLink 999, SWISS-PROT P12830, OMIM 192090, and NCI)
C18250	CDK4_Gene	Cyclin-Dependent_Kinase_Gene	CDK4 Gene|CDK4|CMM3|Cyclin-Dependent Kinase 4 Gene|MGC14458|PSK-J3	Human CDK4 Gene (CDC2/CDKX Family) at 12q14, a cloned gene for Hereditary Melanoma, encodes Cyclin Dependent Kinase 4, a serine/threonine protein kinase involved in control of cell proliferation during G1.  CDK4 forms complexes with D-type cyclins and blocks RB repression of transcription in early G1.  CDC37 and HSP90 enhance CDK4 stability.  Cyclin-dependent kinase inhibitor-2 (p16) inhibits CDK4. (NCI)
C18251	EXT1_Gene	Glycosyltransferase_Gene	EXT1 Gene|EXT|EXT1|Exostoses (Multiple) 1 Gene	A cloned gene for Hereditary Multiple Exostoses, the widely expressed 350 kb human EXT1 Gene (EXT Family) at 8q24.11-q24.13 is composed of eleven exons that encode the tumor suppressor exostosin-1 protein.  A type II transmembrane glycoprotein, EXT1 with exostosin-2 appears to form a Golgi-localized glycosyltransferase complex involved in cell surface heparan sulfate glycosaminoglycan synthesis.  EXT1 and EXT2 show striking similarity and may modulate the hedgehog signaling pathway.  The development of exostoses is mainly due to loss of EXT gene function.  (from SWISS-PROT, OMIM, and NCI)
C18252	EXT2_Gene	Glycosyltransferase_Gene	EXT2 Gene|EXT2	The 108 kb human EXT2 Gene (EXT Family) at 11p12-p11 encodes tumor suppressor exostosin-2 protein.  EXT2 maps to a 3 cM region containing polymorphic D11S903 and flanked by D11S1355 and D11S1361/D11S554.  A type II transmembrane glycoprotein, EXT2 with exostosin-1 appears to form a Golgi-localized glycosyltransferase complex involved in cell surface heparan sulfate glycosaminoglycan synthesis.  EXT2 interacts with an UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase.  EXT1 and EXT2 show striking similarity and may modulate the hedgehog signaling pathway.  The development of exostoses is due mainly to loss of function of EXT genes.  (from SWISS-PROT, OMIM, and NCI)
C18253	STK11_Gene	Serine-Threonine_Protein_Kinase_Gene	STK11 Gene|LKB1|LKB1/STK11 Gene|PJS|STK11|Serine/Threonine Kinase 11 (Peutz-Jeghers Syndrome) Gene	A cloned gene for Peutz-Jeghers Syndrome and 190 kb proximal to D19S886, human LKB1/STK11 Gene (SER/THR family) at 19p13.3 is associated with gastrointestinal tumors, as well as breast and other cancers.  Composed of nine exons transcribed telomere-to-centromere, STK11 extends over 23 kb.  Intron 2 splice junctions deviate from the GT/AG rule.  The mouse gene consists of ten exons over 15 kb.  LKB1, a serine/threonine kinase thought to act in the VEGF signaling pathway, associates with p53 and regulates p53-dependent apoptosis pathways.  (from SWISS-PROT, OMIM, and NCI)
C18254	MEN1_Gene	Transcription_Factor_Gene	MEN1 Gene|MEA I|MEAI|MEN1|Multiple Endocrine Neoplasia 1 Gene|SCG2	Within an 8 cM region between D11S480 and D11S546, human MEN1 Gene at 11q13 is a cloned tumor suppressor gene for Multiple Endocrine Neoplasia, a predisposition for endocrine and carcinoid tumors.  The gene contains ten exons and expresses a ubiquitous 2.8 kb transcript that encodes MEN1 protein, which interacts with and inhibits JUND transcription factor.  Also interacting with SMAD3, menin appears to be required for DNA binding of SMAD3/4 at transcription regulatory sites.  (from SWISS-PROT, OMIM, and NCI)
C18255	PTCH_Gene	Receptor_Gene	PTCH Gene|BCNS|HPE7|NBCCS|PTC|PTC1|PTCH|Patched Homolog (Drosophila) Gene	The PTCH gene is a cloned gene for Basal Cell Nevus Syndrome, associated with skin cancer and childhood brain cancer.  The PTCH gene encodes the sonic hedgehog receptor, a protein with twelve transmembrane domains that represses transcription of genes encoding TGF beta and Wnt family signaling proteins.  PTCH is involved in embryonic development and adult cell growth control.  Sonic hedgehog binding to PTCH appears to activate the 7-transmembrane protein Smoothened by release from PTCH inhibition.  Basal cell carcinoma is associated with mutations that activate Smoothened or inactivate patched, causing excess activity of the hedgehog response pathway.  The human gene is located at 9q31.
C18256	PTEN_Gene	Signaling_Pathway_Gene	PTEN Gene|BZS|MHAM|MMAC1|PTEN|PTEN1|Phosphatase and Tensin Homolog|Phosphatase and Tensin Homolog (Mutated in Multiple Advanced Cancers 1) Gene|TEP1	The PTEN gene is a cloned gene for Cowden's Disease, associated with breast cancer and thyroid cancer.  PTEN contains a tyrosine phosphatase domain and a region of homology to auxilin and tensin (which interacts with actin).  PTEN inhibits insulin-induced IRS1 phosphorylation and IRS1/GRB2/SOS complex formation and influences the PI3 kinase/AKT pathway in FAS-induced apoptosis.  PTEN blocks cell cycle progression in G1 through negative regulation of PI3 kinase/AKT signaling to cyclin-dependent kinase inhibitor p27(KIP1), increasing p27, decreasing cyclin D1, and inhibiting AKT phosphorylation.  PTEN may regulate cell interactions with the extracellular matrix and effect cell migration, integrin-mediated cell spreading, and formation of focal adhesions.  PTEN reduces tyrosine phosphorylation of FAK.  The PTEN gene is transactivated by p53.  The human gene is located at 10q23.3.
C18257	RET_Gene	Receptor_Tyrosine_Kinase_Gene	RET Gene|CDHF12|Gene Rearranged During Transfection|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET|RET Proto-Oncogene (Multiple Endocrine Neoplasia and Medullary Thyroid Carcinoma 1, Hirschsprung Disease) Gene|RET51	Human RET Gene encodes Tyrosine-Protein Kinase Receptor RET, a type I membrane protein receptor for Glial Cell Line-Derived Neurotrophic Factor with an extracellular cadherin-like domain and important in neural crest development. Disruptions of RET are associated with Hirschsprung's disease and Multiple Endocrine Neoplasia, pheochromocytoma, hyperparathyroidism and medullary thyroid cancer.
C18258	MADH4_Gene	Signaling_Pathway_Gene	MADH4 Gene|DPC4|MAD Homolog 4 Gene|MADH4|Mothers Against Decapentaplegic Homolog 4|SMAD, Mothers Against DPP Homolog 4 (Drosophila) Gene|SMAD4|SMAD4/DPC4 Gene	Between D18S1118 and D18S487, human MADH4 Gene (Dwarfin/SMAD family) at 18q21.1 contains eleven exons and is a cloned gene for Juvenile Polyposis and associated with colon cancer.  Critical for transmitting TGFB and related cytokine signals to the nucleus for target gene activation, the encoded SMAD4 tumor suppressor protein recognizes an eight base pair palindromic DNA regulatory sequence.  (from SWISS-PROT, OMIM, and NCI)
C18259	TSC1_Gene	Ligand_Binding_Protein_Gene	TSC1 Gene|KIAA0243|LAM|TSC|TSC1|Tuberous Sclerosis 1 Gene	The TSC1 gene is a cloned gene for Tuberous Sclerosis 1 that encodes the protein hamartin, associated with renal cancer and brain tumor.  Hamartin and tuberin (TSC2), a putative GAP for RAP1 and RAB5, associate physically and may function together in the insulin signaling pathway.  Hamartin may stabilize ubiquitinated tuberin, which contributes to inhibition of cell growth.  Activated ezrin, radixin, and moesin (ERM proteins) promote linkage between integral membrane proteins and cytoskeleton proteins, such as F-actin.  Activation of ERM proteins requires a RHO cascade. Ezrin, radixin, moesin, and F-actin interact with hamartin.  Loss of hamartin leads to loss of cell adhesion and initiates the development of TSC hamartomas.  The human gene is located at 9q34.
C18260	TSC2_Gene	Signaling_Pathway_Gene	TSC2 Gene|TSC2|Tuberous Sclerosis 2 Gene	The TSC2 gene is a cloned gene for Tuberous Sclerosis 2, associated with renal cancer and brain tumor, that appears to function as a tumor suppressor gene.  The product, tuberin, has a region of homology to the GTPase-activating protein GAP3 and stimulates RAP1A GTPase, but not RAP2, HRAS, RAC, or RHO activity.  Tuberin also exhibits GAP activity towards RAB5, a critical component of docking/fusion in the endocytic pathway.  Adaptor rabaptin-5 mediates tuberin association with RAB5.  Data suggest TSC1 and TSC2 may function together in the insulin signaling pathway.  Inactivating mutations of TSC2 cause enhanced growth and increased cell size with no change in ploidy.  The human gene is located at 16p13.3.
C18261	VHL_Gene	Transcription_Factor_Gene	VHL Gene|VHL|Von Hippel Lindau Tumor Supressor Gene	The VHL gene at 3p25 encodes a tumor suppressor nuclear protein that functions via multi-protein complexes associated with transcriptional elongation and ubiquitination. VHL competes with elongin A for binding elongin B and C, and thereby inhibits transcription elongation. The hypoxia-inducible factor-1 (HIF1) alpha subunit binds to VHL and is targeted for destruction by an E3 ubiquitin ligase. HIF1 alpha is stabilized during hypoxia and VHL is present in the hypoxic HIF1 DNA-binding complex. VHL inhibits expression of hypoxia-inducing VEGF and GLUT1 genes. A VHL-responsive element binds transcription factor SP1. VHL binds and inhibits SP1. Accumulation of cyclin-dependent kinase inhibitor p27, due to enhanced protein stability, is VHL dependent and VHL may be involved in regulation of cell cycle exit. The VHL gene is associated with von Hippel-Lindau Syndrome that causes renal cancer, pheochromocytoma, and brain tumors.
C18262	WT1_Gene	Transcription_Factor_Gene	WT1 Gene|GUD|WAGR|WIT-2|WT1|WT33|Wilms Tumor 1 Gene	The WT1 gene encodes a zinc finger DNA-binding protein that acts as a transcriptional activator or repressor depending on the cellular or chromosomal context. WT1 is required for normal formation of the genitourinary system and mesothelial tissues. (OMIM)
C18263	WT2_Gene	Gene_with_Unknown_or_Unclassified_Function	WT2 Gene|MTACR1|WIT-2|WIT2|WT2|Wilms Tumor 2 Gene	The WT2 gene is a second Wilms tumor suppressor gene locus, at 11p13-p15.  Efforts to clone the WT2 gene(s) have not yet been successful.
C18264	Pathogenesis	Pathologic_Process	Pathogenesis	The pathologic, physiologic, or biochemical mechanism resulting in the development of a disease or morbid process. Cf. etiology. (NCI)
C18265	Relapse	Conceptual_Entities	Relapse|REL|relapse	Recurrence of symptoms or signs of a disease after a period of improvement.
C18266	Catabolism	Catabolic_Process	Catabolism	Catabolism is an enzyme-catalyzed biochemical process in which complex molecules are degraded to simpler molecules releasing energy.
C18267	Cathepsin-B	Cathepsin	Cathepsin B|APP Secretase|APPS|Amyloid Precursor Protein Secretase|CTSB|Cathepsin B1|EC 3.4.22.1|Preprocathepsin B	Cathepsin B, encoded by the CTSB Gene, encodes a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of Cathepsin B has been associated with esophageal adenocarcinoma and other tumors. Tumors with overexpression of cathepsins have powerful potential for invasiveness in the early stage of gastric carcinoma. Gastric carcinoma cells that oversecrete cathepsins B have a high invasive and metastatic potential. At least five transcript variants encoding the same protein have been found for this gene. (From LocusLink, PMID 10931446 and NCI)
C18268	Community_Health	Public_Health	Community Health	Community health; community-focused health delivery systems.
C18269	Manpower	Manpower_and_Training	Manpower	The labor force available to do work on a project
C18270	Cigarette_Smoking	Tobacco_Smoking	Cigarette Smoking	Inhaling smoke from tobacco in the form of a cigarette.
C18271	Tyrosinase-Related_Protein-1	Oxidoreductase	Tyrosinase-Related Protein 1|B-Protein|Catalase B|Glycoprotein 75|TRP-1|TYRP|TYRP1|Tyrosinase Related Protein-1	A glycoprotein catalase with a membrane-spanning domain and conserved positions of cysteine and histidine residues, TRP1 shares 40% amino acid sequence homology with mouse tyrosinase but has no tyrosinase activity and converts 5, 6-dihydroxyindole-2-carboxylic acid to melanochrome in premelanosomes.  TRP1 is identical to melanosomal protein, gp75.  (from OMIM 115501 and NCI)
C18272	Substance_Abuse	Personal_Behavior	Substance Abuse	Maladaptive pattern of drug or alcohol use that may lead to social, occupational, psychological, or physical problems.
C18273	Cardiovascular_Pathology	Pathology	Cardiovascular Pathology	Cardiovascular Pathology; a subdiscipline of pathology focusing on diseases of the heart or circulatory system.
C18274	Isotropy	Physical_Phenomena_or_Properties	Isotropy	A quality of directional uniformity in material such that physical properties do not vary in different directions. (from Oilfield glossary).
C18275	Pulmonary_Pathology	Pathology	Pulmonary Pathology	The branch of pathology that focuses the causes and nature and effects of diseases of the lungs and respiratory structures.
C18276	Proteome	Miscellaneous_Molecular_Biology_Terms	Proteome	In its most basic sense the term proteome refer to the total protein-encoding capability of an organism's genome.  It is also used to refer to the actual total expressed protein complement of an organism or to the identifiable proteins of a single tissue or cell type or subcellular compartment.
C18277	Small_G_Protein	G_Protein	Small G Protein	A class of small GTP-binding regulatory proteins regulated by G protein coupled receptors that act as switches in signal transduction pathways.  The nature of the nucleotide bound to the protein determines its activity: GTP in the active state, GDP in the inactive state.  The prototype for this class of proteins is the cellular proto-oncogene RAS.
C18278	PDGFB_Gene	Growth_Factor_Gene	PDGFB Gene|PDGF2|PDGFB|Platelet-Derived Growth Factor Beta Polypeptide (Simian Sarcoma Viral (v-sis) Oncogene Homolog) Gene|SIS|SIS Gene|SSV|c-sis|v-SIS Homolog	Expressed as 2 alternative isoforms in platelets, human PDGFB Gene (PDGF/VEGF Family) encodes 241-aa 27-kDa (precursor) Platelet-Derived Growth Factor-Beta Chain, a potent mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released by platelets upon wounding to stimulate adjacent cell growth. PDGFB can exist as either antiparallel disulfide-linked homodimers or heterodimers with Platelet-Derived Growth Factor Alpha. A-A, B-B, and A-B, dimers can bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. PDGFB mutations are associated with meningioma. Reciprocal t(17;22)(q22;q13) translocations with COL1A1 result in unregulated growth factor expression and are associated with DFSP.
C18279	Single_Nucleotide_Polymorphism	Genetic_Polymorphism	Single Nucleotide Polymorphism|Polymorphism, Single Base|Polymorphism, Single Nucleotide|SNP	Single Nucleotide Polymorphism (SNP) consists of a variation at an appreciable frequency between individuals of a single interbreeding population of a single nucleotide, due to base substitution, at an equivalent location within a sequence of genetic material. SNPs occur, on average, once every 1000 bases and can be used in gene mapping and linkage analysis.
C18280	Cytogenetic_Analysis	Cytological_Techniques	Cytogenetic Analysis|Cytogenetic Techniques	Techniques for analysis of chromosomal and subchromosomal properties and structures, such as those to diagnose, classify, screen for, or manage genetic diseases and abnormalities.
C18281	Heterotrimeric_G_Protein	G_Protein	Heterotrimeric G Protein	Heterotrimeric guanine nucleotide-binding proteins (G proteins) are signal transducers, attached to the cell surface plasma membrane, that connect receptors to effectors and thus to intracellular signaling pathways (1). Receptors that couple to G proteins communicate signals from a large number of hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. After the first four G proteins (Gs, Gt, Gi, and Go) were identified by biochemical purification, a large number of G proteins and their subunits were identified by cDNA cloning (2). G proteins consist of three subunits, alpha, beta, and gamma. When signaling, they function in essence as dimers because the signal is communicated either by the Ga subunit or the Gbg complex. In most cases, Gbg subunits cannot be dissociated under nondenaturing conditions. Currently there are 20 known G, 6 G, and 11 G subunits. (from Science 2002;296:1636-9)
C18282	AP-2_Gamma_Protein	AP-2_Family_Transcription_Factor	AP-2 Gamma|AP-2 Transcription Factor Gamma|AP2-Gamma|Activating Enhancer-Binding Protein 2 Gamma|ERF1|Estrogen Receptor Factor 1|TFAP2C|Transcription Factor AP-2 Gamma|Transcription Factor ERF-1	A transcription factor that belongs to the AP-2 family and binds viral and cellular enhancers containing the consensus 5'-GCCNNNGGC-3' DNA motif. AP-2 Gamma appears to regulate expression of genes required for ectodermal development. (from SWISS-PROT Q92754, OMIM 601602, and NCI)
C18283	VAV1_Protein	Guanine_Nucleotide_Exchange_Factor	VAV1 Protein|VAV|VAV1|VAV1 Gene Product	VAV1 protein is a proto-oncogene product with features of a transcription factor, including an N-terminal acidic region, a proline-rich region, and two zinc finger-like domains.  VAV also has an SH2, two SH3, and a guanosine exchange factor domain.  Truncation of its N-terminus, containing an HLH domain and leucine zipper, activates its oncogenic potential.  Wild type VAV is transcribed in hematopoietic cells, including erythroid, lymphoid, and myeloid lineages.  VAV-dependent signaling pathways regulate the maturation of T-cells.  (from OMIM 164875 and NCI)
C18284	ST5_Protein	Signaling_Protein	ST5 Protein|HTS1|P126|P70|P82|ST5|Suppression of Tumorigenicity 5	ST5 protein contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. (from LocusLink)
C18285	Nuclear_Receptor_Co-Repressor-1	Transcription_Repressor_Corepressor	Nuclear Receptor Co-Repressor 1|KIAA1047|N-CoR|N-CoR1|NCOR1|Nuclear Receptor Corepressor|TRAC1|Thyroid Hormone- and Retinoic Acid Receptor-Associated Corepressor 1|hCIT529I10|hN-CoR	Nuclear Receptor Co-Repressor 1, encoded by the NCOR1, mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. This protein is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined. (from LocusLink)
C18286	Peroxisome_Proliferator-Activated_Receptor_Binding_Protein	DNA_Binding_Protein	Peroxisome Proliferator-Activated Receptor Binding Protein|PPAR Binding Protein|PPARBP|PPARG Binding Protein|TRAP220|Thyroid Hormone Receptor-Associated Protein Complex, 220 KDa Subunit|Thyroid Receptor Interacting Protein 2	TRAP220 (thyroid hormone receptor-associated protein) is a recently cloned nuclear receptor coactivator, which interacts with several nuclear receptors in a ligand-dependent manner and stimulates transcription by recruiting the TRAP mediator complex to hormone responsive promoter regions. TRAP220 has been shown to interact with thyroid hormone receptors, vitamin D receptors, peroxisome proliferator-activated receptors, retinoic acid receptors and estrogen receptors. Our work supports the assumption that TRAP220 plays an important role in growth and differentiation of central nervous system and may have a function in certain areas of adult brain. (from Eur J Neurosci. 2002;16:671-83)
C18287	Caspase-10	Caspase	Caspase-10|ALPS2|Apoptotic Protease MCH-4|CASP10|CASP10 Protein|Caspase 10, Apoptosis-Related|Caspase 10, Apoptosis-Related Cysteine Protease|Cysteine Protease|EC 3.4.22.-|FADD-Like ICE2|FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2|FLICE2|Fas-Associated Death Domain Protein|ICE-Like Apoptotic Protease 4|Interleukin-1B-Converting Enzyme 2|MCH4	Caspase-10 originally was identified as a novel ICE/CED-3 protease, designated FLICE2 (FADD (fas-associated via death domain)-like ICE 2). It has two death effector domains (DEDs) that bind to the DED in the adapter molecule FADD and recruits TNFR1 to form complexes with these receptors. Caspase-10 is therefore involved in the TNFR1 induced apoptosis. Caspase-10 cleaves and activates caspase-3, -4, -6, -7, -8, and -9, which causes the proteolytic cleavage of many key proteins such as PARP (poly (ADP-ribose) polymerase). Cleavage of PARP occurs in many different systems during apoptosis and is the hallmark of programmed cell death.
C18288	ELK-1_Protein	ETS_Family_Protein	ELK-1 Protein|ELK1|ELK1 Protein|ELK1, Member of ETS Oncogene Family|ETS-Domain Protein ELK-1	ELK1 Protein is a member of the ELK subfamily of ETS DNA-binding transcription factors.  (from OMIM 311040 and NCI)
C18289	VEG_Inhibitor	Tumor_Necrosis_Factor_Family_Protein	Tumor Necrosis Factor Ligand Superfamily Member 15|TNF Ligand-Related Molecule 1|TNFSF15|VEGI|Vascular Endothelial Growth Inhibitor	Vascular Endothelial Growth Inhibitor is a TNF-related type II transmembrane protein, with an extracellular C-terminus, a single transmembrane domain, and a short cytoplasmic tail.  VEGI is expressed as multiple mRNAs in most tissues, arterial endothelial cells, and monocytes, but not in B- or T-cells.  Soluble VEGI markedly reduces vascularization and inhibits the growth of aortic endothelial cells and colon carcinomas.  VEGI appears to be an angiogenesis inhibitor that directly inhibits endothelial cell proliferation.  VEGI appears to cause endothelial cell apoptosis by activation of the SAPK/JNK stress protein kinases, p38 MAPK, and caspase-3.  (from OMIM 604052 and NCI)
C18290	Glutathione_S-Transferase-M1	Glutathione_S-Transferase	Glutathione S-Transferase M1|GST Class-Mu-1|GSTM1|GSTM1 Protein|GSTM1-1|GSTM1-2|GTH4|Glutathione S-Transferase Mu-1|HB Subunit 4	Glutathione S-transferases (GSTs) are a family of phase II enzymes which comprise at least four classes, a, m, p and q. The GSTM1 gene is one of the m-class forms and is classified into three genotypes, GSTM1A, GSTM1B, and GSTM1 (0/0). The GSTM1 (0/0) genotype due to inherited homozygous deletion of both alleles has no enzymatic activity.  The GSTM1 (0/0) genotype has been possibly implicated in elevated risks of lung and urothelial cancer. (Japanese Journal of Clinical Oncology,Pages 657-660).
C18291	RALA_Protein	RAS_Superfamily_Protein	RALA Protein|RALA|RALA Gene Product|RAS Related Protein A	Encoded by human RALA Gene (RAS GTPase Family), 206-aa 24-kDa GTP-binding RAS-like RALA Protein interacts with RALBP1 via its effector domain and likely mediates some cell surface transmembrane receptor signaling. (NCI)
C18292	PLZF-RARalpha	Fusion_Protein	PLZF-RARalpha|PLZF-RARA Chimera|Promyelocytic Leukemia Zinc Finger Protein/Retinoic Acid Receptor Alpha Chimera|ZNF145/RARA Chimera	Translocation t(11;17)(q23;21) fuses the PLZF gene on 11q23.1 to the RARA gene on chromosome 17 producing a 'dominant-negative' PLZF-RARA fusion protein in myeloid cells and resulting in APL.  The oncogenic retinoic acid receptor mediates leukemogenesis through aberrant chromatin acetylation.  Through the RAR-alpha CoR box, PLZF-RAR-alpha fusion proteins recruit the NCOR/histone deacetylase complex.  (from OMIM 176797 and NCI)
C18293	RALB_Protein	RAS_Superfamily_Protein	RALB Protein|RALB|RALB Gene Product|RAS Related Protein B	RAL proteins share homology and some properties with the RAS proteins.  RALB is a GTP-binding protein.  (from OMIM 179551 and NCI)
C18294	Histone_Deacetylase-2	Histone_Deacetylase	Histone Deacetylase 2|HDAC2|Transcriptional Regulator Homolog RPD3	One of three identified histone deacetylases with similarity to the yeast global transcriptional regulator Rpd3p, HDAC2 is found in transcription factor co-repressor complexes that include HDAC1.  BRCA1 interacts with HDAC1 and HDAC2.  Acetylation of histone destabilizes nucleosomes allowing transcription factors access to recognition elements in DNA.  Deacetylation reseals the chromosomal package, repressing transcription.  DNMT1 can establish a repressive transcription complex with HDAC2, and DMAP1.  HDAC2 joins DNMT1 and DMAP1 during late S-phase, suggesting how histones may become deacetylated in heterochromatin following replication.  (from OMIM 605164 and NCI)
C18295	Matriptase	Serine_Protease	Matriptase|Epithin|MT-SP1|Membrane-Type Serine Protease 1|Prostamin|ST14|Serine Protease TADG-15|Suppression of Tumorigenicity 14|Suppressor of Tumorigenicity 14|Tumor Associated Differentially Expressed Gene 15 Protein	Expressed in prostate, kidney, lung, small intestine, stomach, colon, placenta, spleen, liver, leukocytes, and thymus, human ST14 Gene (Peptidase S1 Family) encodes an 855-aa 95-kD membrane-associated serine protease, Matriptase. ST14 contains an N-region integrin-binding site, N-glycosylation sites, tandem LDLR class A cysteine repeats, CUB domains, a putative proteolytic activation site, a C-terminal trypsin-like serine protease region, an S1 pocket, an S2 subsite, and an S4 cavity. Protease specificity involves additional cleavage site residues. Complexed with 40-kD SPINT1, a Kunitz-type inhibitor, ST14 is activated by sphingosine 1-phosphate, degrades extracellular matrix, and cleaves/activates HGF and urokinase plasminogen activator. ST14 may play a role in cancer invasion and metastasis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C18296	Pancreatic_Enzyme	Hydrolase	Pancreatic Enzyme|pancreatic enzymes	Pancreatic enzymes are comprised primarily of proteases, lipase and amylase that catalyze the breakdown of fats, carbohydrates and proteins during the digestion of food. However, the pancreas also produces many other digestive enzymes such as ribonuclease, deoxyribonuclease, gelatinase and elastase.
C18297	X-Ray_Cross_Complementing_Group	Miscellaneous_Molecular_Biology_Terms	X-Ray Cross Complementing Group|XRCC Group	A genetic complementation group for X-ray sensitivity.
C18298	Hepatitis-B_Antigen_Peptide	Viral_Protein	Hepatitis B Antigen Peptide|peptide, hepatitis B antigen
C18299	Polymorphic_Microsatellite_Marker	Genetic_Marker	Polymorphic Microsatellite Marker	Short repeats of nucleotide sequences present throughout the genome which exhibit variations within a population.
C18300	DNA_Maintenance	DNA_Maintenance_Process	DNA Maintenance|DNA Stability	DNA Maintenance involves cellular mechanisms that maintain DNA integrity. In many organisms, maintenance of DNA integrity requires not only faithful DNA replication, but also DNA repair and recombination. (NCI)
C18301	TAL1_Gene	Transcription_Factor_Gene	TAL1 Gene|SCL|T-Cell Acute Lymphocytic Leukemia 1 Gene|TAL1|TCL5	The TAL1 gene is associated with T-cell leukemia, due to gene deletion or translocation.  TAL1 gene products, possible transcriptional regulatory factors, possess the bHLH motif, a DNA-binding domain common to many transcription factors.  TAL1 can form heterologous complexes with E47 or E12 that recognize the E-box DNA motif.  TAL1 appears to be essential for embryonic blood formation. The human gene is located at 1p32.
C18302	Mutation_Analysis	Genetic_Techniques	Mutation Analysis	A research technique to test for the presence of a specific mutation or a set of mutations as opposed to complete gene sequencing or mutation scanning, which detect most, if not all, mutations in the tested region. (From GeneTests).
C18303	DNA_Ploidy_Analysis	Cytogenetic_Analysis|DNA_Analysis	DNA Ploidy Analysis	The test is used to measure nuclear deoxyribonucleic acid (DNA) content (ploidy or multiple of the basic number of chromosomes in a cell) of solid tumors by using fluorescent dye which stains nucleic acids. Used as a prognostic indicator
C18304	Clonality	Properties_or_Attributes	Clonality	Related by decent from a single progenitor cell.
C18305	HUMARA_Assay	Hormone_Receptor_Test	HUMARA Assay|HUMARA|HUMARA Analysis|Human Androgen Receptor Gene Assay	Human androgen receptor gene assay.  This assay was used to detect X chromosomal inactivation for diagnosis of X-linked conditions, ie. Kennedy disease, agammaglobulinemia, and others.
C18306	Videothoracoscopy	Thoracoscopy	Videothoracoscopy
C18307	Tumor_Replication_Error_Analysis	DNA_Analysis	Tumor Replication Error Analysis	Certain tumors contain widespread deletions within mono- and dinucleotide repeat sequences in their DNA, referred to as the replication error (RER+) phenotype. The RER+ status of tumors is usually determined by examining several dinucleotide and mononucleotide repeats for size variations when compared with the matching normal DNA.(NCI2005)
C18308	Fc-Gamma_Receptor-II	Fc_Receptor	Fc-Gamma Receptor II	Generally expressed in monocytes, macrophages, polymorphonuclear cells, NK cells, T- and B-lymphocytes, and platelets, Fc-Gamma Receptors II are type I cell surface membrane protein low affinity receptors for aggregated IgG Fc region with 2 extracellular IgC2 domains and cytoplasmic ITIM or ITAM motifs involved in cell activation upon receptor aggregation. IgG binding initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. (NCI)
C18309	Polymorphism_Analysis	Mutation_Detection	Polymorphism Analysis|Polymorphism Detection	Chemical or physical tests to determine DNA sequence variation
C18310	Flu_Matrix_Protein	Viral_Protein	Flu Matrix Protein|FLU-MP|Flu Matrix|Flu Matrix Peptide|Influenza Matrix Peptide
C18311	NAT2_Gene	Transferase_Gene	NAT2 Gene|AAC2|N-Acetyltransferase 2 (Arylamine N-Acetyltransferase) Gene|NAT-2|NAT2	A bladder cancer modifier, human NAT2 Gene (NAT family) at 8p23.1-p21.3 encodes an Arylamine N-Acetyltransferase family member responsible for N-acetylation of carcinogens.  None of the coding sequence is interrupted by introns.  NAT1 and NAT2 code for genetically invariant and variant NAT proteins, respectively.  NAT1 is responsible for N-acetylation of certain arylamine drugs, whereas rapid and slow acetylation of therapeutic and carcinogenic agents is due to genetic variation in the NAT2 coding region.  (from SWISS-PROT, OMIM, and NCI)
C18312	ETV6_Gene	ETS_Family_Gene	ETV6 Gene|ETS Variant Gene 6|ETS Variant Gene 6 (TEL Oncogene) Gene|ETV6|TEL Gene	Encoding a transcription factor with HLH motif and ETS DNA-binding domain, human ETV6 Gene (ETS Family) at 12p13 includes the TEL oncogene.  The 240 kb gene is flanked by D12S1697 (5-prime) and D12S98 (3-prime); D12S1095 and D12S89 are located in the first intron.  The HLH motif is coded by exons 3-4; exons 6-8 encode the ETS domain.  ETV6 is specifically required for hematopoiesis within the bone marrow.  Frequently rearranged in myeloid or lymphoid leukemias, TEL exhibits fusion translocations with PDGFRB, AML1, KIP, MN1, NTRK3, ACS2, ABL2, BTL, ARNT, and JAK2. (from SWISS-PROT, OMIM, and NCI)
C18313	Hormone_Receptor_Test	Test|Test_Generic	Hormone Receptor Test|hormone receptor test	A hormone receptor test measures the amount of certain hormone receptors proteins in cancer tissue. Hormones (such as estrogen and progesterone that naturally occur in the body) can attach to these proteins. If the test is positive, it indicates that the hormone is probably helping the cancer cells grow.(NCI2005)
C18314	Differentiation	Histopathologic_Grade	Differentiation|differentiation	In cancer, refers to how mature (developed) the cancer cells are in a tumor. Differentiated tumor cells resemble normal cells and tend to grow and spread at a slower rate than undifferentiated or poorly differentiated tumor cells, which lack the structure and function of normal cells and grow uncontrollably.
C18315	Transrectal_Ultrasound	Ultrasound_Imaging	Transrectal Ultrasound|transrectal ultrasound	A procedure used to examine the prostate. An instrument is inserted into the rectum, and sound waves bounce off the prostate. These sound waves create echoes, which a computer uses to create a picture called a sonogram.
C18316	Xerogram	Medical_Image	Xerogram|xerogram|xeroradiograph	A picture of the body recorded on paper rather than on film. Also called a xeroradiograph.
C18317	Sun_Protection_Factor	Attributes_of_Chemicals	Sun Protection Factor|SPF|sun protection factor	SPF. A scale for rating the level of sunburn protection in sunscreen products. The higher the SPF, the more sunburn protection it provides.  Sunscreens with an SPF value of 2 through 11 provide minimal protection against sunburns.  Sunscreens with an SPF of 12 through 29 provide moderate protection, which is adequate for most people.  Those with an SPF of 30 or higher provide high protection against sunburn and are sometimes recommended for people who are highly sensitive to the sun.
C18318	RevM10_Gene	Transduction_Gene	RevM10 Gene|RevM10 gene	An antiviral gene being studied for treatment of cancer in patients who have HIV, the virus that causes AIDS.
C18319	Core-Binding_Factor_Alpha	Transcription_Coactivator	Core-Binding Factor Alpha|AML-1|AML-1 Protein|AML1|AML1 Protein|Acute Myeloid Leukemia-1 Protein|CBF-Alpha|CBF-Alpha B|CBFA2|Core-Binding Factor Alpha B Subunit|Core-Binding Factor, Runt Domain, Alpha Subunit 2|PEA2-Alpha B|PEBP2-Alpha B|Polyomavirus Enhancer Binding Protein 2 Alpha B Subunit|RUNX1|Runt-Related Transcription Factor 1|SL3-3 Enhancer Factor 1 Alpha B Subunit|Sl3/AKV Core-Binding Factor Alpha B Subunit	Part of the heterodimeric transcription factor Core-Binding Factor.  The CBFalpha subunit binds directly to the enhancer core DNA sequence on target genes, whereas the beta subunit does not bind the DNA directly but increases the affinity and stabilizes the binding of the alpha subunit to the DNA.  Three homologous genes can encode for the CBFalpha subunit.  Disruption of CBFA2 is associated with many leukemias, including AML, ALL, and CML.
C18320	ETO_Protein	Transcription_Repressor_Corepressor	ETO Protein|Acute Myelogenous Leukemia 1 Translocation 1 Protein MTG8A|Acute Myelogenous Leukemia 1 Translocation 1 Protein MTG8B|Acute Myelogenous Leukemia 1 Translocation 1 Protein MTG8C|Acute Myelogenous Leukemia 1 Translocation 1, Cyclin-D Related|CBFA2T1|Core-Binding Factor, Alpha Subunit 2, Translocated to 1|Core-Binding Factor, Runt Domain, Alpha Subunit 2|Core-Binding Factor, Runt Domain, Alpha Subunit 2, Translocated to 1, Cyclin D-Related|Cyclin D Related Protein|ETO|Eight Twenty One Protein|MTG8 Protein|Zinc Finger MYND Domain Containing Protein 2	ETO is a putative transcription factor containing one MYND-type zinc finger and most abundantly expressed in the brain.  Two isoforms, MTG8A and MTG8B, are produced by alternative splicing.  (from Swiss-Prot Q06455 and NCI)
C18321	FLI1_Gene	ETS_Family_Gene	FLI1 Gene|EWSR2|Ewing Sarcoma Breakpoint Region 2|FLI1|Friend Leukemia Virus Integration 1 Gene|SIC-1	Human FLI1 Gene (ETS family) at 11q24 encodes ERGB Transcription Factor, which contains a PNT domain and recognizes 5 prime-C(CA)GGAAGT-3 prime DNA.  Two isoforms may be produced by alternative splicing.  ETS1 and FLI1 reside within 400 kb and are transcribed in the same orientation.  The gene is flanked centromerically by an ALL-associated t(4;11)(q21;q23) translocation breakpoint and telomerically by a Ewing-associated t(11;22)(q24;q12) breakpoint.  FLI1 protein forms homodimers, or heterodimers with ETV6/TEL1.  ETS transcription factors regulate TGFBR2 gene expression. (NCI)
C18322	EWSR1_Gene	Ligand_Binding_Protein_Gene	EWSR1 Gene|EWS|EWSR1|Ewing Sarcoma Breakpoint Region 1|Ewing Sarcoma Breakpoint Region 1 Gene	Containing Ewing sarcoma breakpoint region 1, human EWSR1 Gene (TET Family) at 22q12 encodes a putative RNA-binding protein that may function as a repressor.  Differential splicing produces two transcripts expressed in a variety of cells.  The N-terminal domain may regulate specificity of the EWS RNA-binding activity.  Possible members of a new family of RNA binding proteins, RBP56, FUS/TLS, and EWS may be derived from an ancestral gene.  A large group of Ewing sarcoma cases result from translocations involving FLI1 or ERG; the chimeric product contains a DNA-binding domain of these ETS factors in place of the EWSR1 RNA-binding domain.  Desmoplastic small round cell tumor is associated with a chromosomal translocation involving WT1 and EWS.  (from SWISS-PROT, OMIM, and NCI)
C18323	CDKN2B_Gene	Cyclin-Dependent_Kinase_Inhibitor_Gene	CDKN2B Gene|CDKN2B|Cyclin-Dependent Kinase Inhibitor 2B Gene|INK4B|MTS2|P15|TP15	The tumor suppressor CDKN2B gene encodes cyclin-dependent kinase inhibitor 2B, a member of the p16(INK4) family referred to as p15(INK4B).  Expression of CDKN2B is induced by TGF beta, suggesting that p15 may act as an effector of TGFB-mediated cell cycle arrest in growth regulation.  The human gene is located at 9p21.
C18324	BAX_Gene	Apoptosis_Promoter_Gene|BCL-2_Gene_Family	BAX Gene|BAX|BCL2-Associated X Protein Gene|BCL2L4	Caspase-activated BID triggers homooligomerization of BAX, the BAX gene product. Insertion of cytosolic BAX into mitochondrial membranes stimulates apoptosis. BAX shows extensive amino acid homology with BCL2 and forms homo- and heterodimers with BCL2, which controls mitochondrial membrane permeability. The ratio of BAX to BCL2 may determine survival or death following an apoptotic stimulus. BAX binds to PTPC, the mitochondrial porin channel VDAC, involved in regulation of mitochondrial membrane permeability. BAX and mitochondrial protein ANT cooperate within PTPC to increase mitochondrial membrane permeability, which causes release of cytochrome C into the cytoplasm, activating death-driving proteolytic caspases. The BAX gene at 19q13.3-q13.4 encodes at least four proteins by alternate splicing. Its promoter contains consensus p53-binding sites. A primary-response gene for p53, BAX is involved in a p53-regulated pathway for induction of apoptosis.
C18325	C-MET_Gene	Growth_Factor_Receptor_Gene	MET Gene|C-MET|HGFR Gene|Hepatocyte Growth Factor Receptor Gene|MET|Met Proto-Oncogene (Hepatocyte Growth Factor Receptor) Gene	The C-MET gene is a cloned gene for Hereditary Papillary Renal Carcinoma, associated with renal cancer.  c-MET is related to the insulin receptor and ABL oncogene.  A cell surface receptor-like tyrosine kinase comprised of disulfide-linked 50 kD (alpha) and 145 kD (beta) subunits.  In the fully processed c-MET product, the alpha subunit is extracellular, and the beta subunit has extracellular, transmembrane, and tyrosine kinase domains, as well as sites of tyrosine phosphorylation.  The beta subunit of the c-MET proto-oncogene product is the cell surface receptor for hepatocyte growth factor.  The human gene is located at 7q31.
C18326	ETS_Family_Gene	Transcription_Factor_Gene	ETS Family Gene|ETS Family Proto-Oncogenes	The Ets family of transcription factors includes nuclear phosphoproteins that are involved in cell proliferation, differentiation and oncogenic transformation. The family is defined by a conserved DNA-binding domain (the ETS-DBD), which forms a highly conserved, winged, helix-turn-helix structural motif. As targets of the Ras-MAPK signaling pathway, Ets proteins function as critical nuclear integrators of ubiquitous signaling cascades. To direct signals to specific target genes, ETS proteins interact with other transcription factors that determine the binding specificity of ETS proteins to RAS-response elements in target genes.
C18327	ETS1_Gene	ETS_Family_Gene	ETS1 Gene|ETS|ETS1|ETS1 Proto-Oncogene|v-ETS Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian) Gene|v-ets Avian Erythroblastosis Virus E26 Oncogene Homolog 1	Human ETS1 Gene (ETS Family) at 11q23.3 expresses a 6.8 kb mRNA that encodes 42-52 kD DNA-binding phosphoprotein transcription factors that interact with purine-rich sequences in promoter/enhancer regions of genes, such as TCRA and p16(INK4A).  The ETS family includes ETS1, ETS2, ERG, ELK1, and ELK2. (from SWISS-PROT, OMIM, and NCI)
C18328	ETS2_Gene	ETS_Family_Gene	ETS2 Gene|ETS2|ETS2 Proto-Oncogene|v-ETS Erythroblastosis Virus E26 Oncogene Homolog 2 (Avian) Gene|v-ets Avian Erythroblastosis Virus E26 Oncogene Homolog 2	Human ETS2 Gene (ETS Family) at 21q22.3 encodes a DNA-binding transcription factor expressed in a variety of cell types.  ERG is situated just proximal to ETS2, which has no promoter TATA box or CAAT box; it has an alternative structure that serves a comparable function.  Activity of the product is potentiated by the RAS-RAF-MEK cascade and inhibited by the HLH protein ID1.  ETS2 appears to have a role in skeletal development.  The ETS family includes ETS1, ETS2, ERG, ELK1, and ELK2.  (from SWISS-PROT, OMIM, and NCI)
C18329	Disease_Marker	Biomarker	Disease Marker|Marker, Disease|Markers, Disease	Specific molecular signature of disease, physiological measurement, genotype structural or functional characteristic, metabolic changes, or other determinant that may simplify the diagnostic process, make diagnoses more accurate, distinguish different causes of disease, or enable physicians to make diagnoses before symptoms appear and to track disease progression.
C18330	NME1_Gene	Regulatory_Gene	NME1 Gene|NDPKA|NM23|NM23 Gene|NM23-H1|NM23H1|NME1|Non-Metastatic Cells 1, Protein (NM23A) Expressed In Gene|Nonmetastatic Protein 23 Gene|Nucleoside Diphosphate Kinase-A Gene	Involved in breast tumor cell metastasis, the 8.5 kb human NM23 Gene (NDK family) at 17q21.3 consists of four introns and five exons encoding nuclear/cytoplasmic Nucleoside Diphosphate Kinase A (p19/NM23) whose expression correlates with cell proliferation and inversely with metastatic potential.  The exon-intron boundaries are well conserved.  The serine phosphorylated A/B hexamer participates in nucleoside triphosphate synthesis, other than ATP.  Murine NM23 is a myeloid differentiation-inhibiting factor.  Human NM23 is also similar to awd (Drosophila), a putative transcription factor; awd mutations cause abnormal morphology and aberrant differentiation.  A high purine DNA-binding factor, NM23 is PuF transcription factor, which binds to a MYC P1 promoter element and activates MYC P1 and P2 transcription initiation.  (from SWISS-PROT, OMIM, and NCI)
C18331	Oncogene_AP2	TFAP2A_Gene	Oncogene AP2|Activator Protein 2 Gene	Human transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) (TFAP2A) gene, located at 6p24, encodes transcription factor AP-2 alpha. This gene is developmentally regulated and expression is induced by retinoic acid. Alternative splicing of the AP2 gene produces four mRNA transcripts, resulting in four protein isoforms. One of these proteins is a negative regulator of transcriptional activation by AP-2.
C18332	Oncogene_B-LYM	Oncogene	Oncogene B-LYM|B-Lymphoma Associated Oncogene|BLYM	A transforming gene activated in certain human B lymphoid tumors, B-lym was originally detected by transfection of NIH 3T3 cells with DNA from Burkitt lymphomas.  B-lym contains regions of similarity to the amino terminal region of transferrins.
C18333	Oncogene_FGR	FGR_Gene	Oncogene FGR	Human Oncogene FGR is a mutated variant of FGR Gene (SRC Family), which encodes 529-aa 60-kDa p55-FGR, a protein tyrosine kinase that may bind PTPNS1 and contains 1 SH2 and 1 SH3 domain. Oncogene FGR disrupts normal cell function.
C18334	Oncogene_LCK	LCK_Gene	Oncogene LCK	Human Oncogene LCK is a mutated variant of LCK Gene, which encodes p56LCK, a lymphocyte-specific tyrosine protein kinase with an SH2 and SH3 domain. LCK may participate in T-cell activation; p56LCK regulates allelic exclusion at the TCR beta locus. It binds to CD4, CD8 and IL-2R beta chain cytoplasmic domains. p56LCK is quickly activated by mIg cross-linking on B-cells or by TCR cross-linking. Pre-TCR co-localizes with p56LCK kinase in membrane rafts resulting in phosphorylation of CD3-epsilon and ZAP70. p56LCK, in the TCR complex, activates DNA binding of STAT5A and STAT5B. Oncogene LCK disrupts normal cell function.
C18335	Oncogene_DBL	MCF2_Gene	Oncogene DBL|DBL|Diffuse B-Cell Lymphoma Oncogene|MCF.2 Cell Line Derived Transforming Sequence|MCF2|MCF2 Gene|Oncogene MCF2|Oncogene, DBL|Oncogene, MCF-2	Human oncogene DBL is a mutated form of the MCF.2 cell line derived transforming sequence (MCF2) gene, located at Xq27, which encodes 4 alternative variants of the proto-oncogene DBL protein. Activation of the DBL oncogene is generated by 5-prime recombination with chromosome 3pter-p21 and by 3-prime recombination with chromosome 16p13-q22.
C18336	MEL_Gene	RAS_Family_Gene	RAB8A Gene|MEL|MEL Transforming Oncogene Homolog|Melanocyte Transforming Oncogene Homolog|RAB8|RAB8 Homolog	Human MEL Gene (RAB/YPT Family/RAS Superfamily) encodes 207-aa 24-kDa RAB8 Protein, containing the 4 GTP/GDP-binding sites present in all RAS small GTPase GTP/GDP-binding proteins and a C-terminal CAAX motif characteristic of many RAS members but not found in YPT1 and most RAB proteins. RAB8 does exhibit strong similarity with mammalian YPT1 proteins; the putative effector-binding site is similar to that of RAB/YPT proteins. Like other RAB/YPT family proteins, RAB8 may play a role in protein transport from endoplasmic reticulum to Golgi and plasma membrane, vesicular trafficking, or neurotransmitter release. RAB8 may interact with MAP4K2 and SYTL4. (NCI)
C18337	PIM1_Gene	Serine-Threonine_Protein_Kinase_Gene	PIM1 Gene|PIM|PIM-1 Oncogene Gene|PIM1|Provirus Insertion Site Gene-1	Serine/threonine-protein kinase; regulated by hematopoietic cytokine receptors; synergy with c-MYC in cell proliferation and in apoptosis induction (through an enhancement of the activation of caspase-3 -like proteases; Cdc25A (cell cycle phosphatase) is a substrate for Pim-1.
C18338	RAF1_Gene	Serine-Threonine_Protein_Kinase_Gene	RAF1 Gene|MIL|Mill Hill-2 Viral Oncogene Homolog|RAF-1|RAF1|v-RAF-1 Murine Leukemia Viral Oncogene Homolog 1Gene	Raf-1 is a MAP kinase kinase kinase (MAP3K) which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated Raf-1 can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2 which in turn phosphorylate to activate the serine/threonine specific protein kinases ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. (LocusLink)
C18339	Oncogene_ROS	ROS1_Gene	Oncogene ROS|Avian UR2 Sarcoma Virus Oncogene Homolog 1	Highly-expressed in a variety of tumor cell lines, human Oncogene ROS is a mutated variant of ROS1 Gene, which belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The encoded type I integral membrane protein, Tyrosine-Protein Kinase ROS, with tyrosine kinase activity may function as a growth or differentiation factor receptor. Oncogene ROS1 disrupts normal cell function.
C18340	G-Protein_Oncogene	Oncogene	Oncogenes, G-Proteins	Mutated forms of G-protein genes which encode a diverse group of regulatory proteins that act as molecular switches. Under normal cellular conditions, the activity of these proteins is tightly controlled. Activation of G-protein proto-oncogenes via mutation results in G-protein oncogenes. These aberrant genes express protein products that disrupt normal cell function.
C18341	Growth_Factor_Oncogene	Oncogene	Oncogenes, Growth Factor	Mutated forms of growth factor genes which encode a diverse group of extracellular regulatory growth factor signaling molecules. These protein products play roles in the division, growth, proliferation, survival and differentiation of cells. Under normal cellular conditions, the activity of these proteins is tightly controlled. Activation of growth factor proto-oncogenes via mutation results in growth factor oncogenes. These aberrant genes express protein products that disrupt normal cell function.
C18342	Nuclear_Protein_Oncogene	Oncogene	Oncogenes, Nuclear Protein	Oncogenes that encode nuclear proteins.
C18343	Protein-Kinase_Oncogene	Oncogene	Oncogenes, Protein-Kinase	Human Protein-Kinase Oncogenes are mutated variants of Kinase Family Genes, which encode diverse Protein Kinases. Protein kinase enzymes catalyze the conversion of a protein to a phosphoprotein by covalently transferring the terminal, gamma phosphate group from ATP to a variety of substrates that typically play key regulatory roles in diverse cellular functions. Protein-Kinase oncogenes disrupt normal cell function.
C18344	Tyrosine-Kinase_Oncogene	Protein-Kinase_Oncogene	Oncogenes, Tyrosine-Kinase	Activated forms of tyrosine kinase family proto-oncogenes that contribute to the development of cancer. These proto-oncogenes encode tyrosine kinase proteins, which are enzymes that play a major role in mitogenic signaling by catalyzing the phosphorylation of tyrosine residues in proteins. Tyrosine kinase oncogenes exhibit aberrant gene expression, resulting in elevated levels of their protein products which disrupts mitotic checkpoints.
C18345	MDM2_Gene	Ligand_Binding_Protein_Gene	MDM2 Gene|MDM 2|MDM2|MDM2, Transformed 3T3 Cell Double Minute 2, p53 Binding Protein (Mouse) Gene|p53-Binding Protein Gene	Flanked by microsatellites D12S80 and D12S83, human MDM2 Gene (MDM2/MDM4 family) at 12q14.3-q15 encodes a 90 kD ubiquitin ligase E3 phosphoprotein that complexes with p53 in S/G2/M, targeting its degradation and inhibiting p53-mediated gene transactivation.  The 25 kb murine gene contains at least twelve exons and MDM2 expression is regulated by the RAS/MAPK pathway.  Upon DNA damage, phosphorylation of p53 suppresses interaction with MDM2 and p14(ARF) inhibits MDM2 activity.  Interaction with MDM2 inhibits RB protein.  MDM2 amplification is found in some cancers and may lead to escape from p53-regulation of growth control. (from SWISS-PROT, OMIM, and NCI)
C18346	NOTCH4_Gene	Receptor_Gene	NOTCH4 Gene|INT3|Int3 Gene|NOTCH4|Notch Homolog 4 (Drosophila) Gene|Notch-4/Int-3 Gene	The 30 kb human Notch-4 Gene (Notch family) at 6p21.3 resides in a MHC class III/II junction region and contains thirty exons widely expressed as a major 6.7 kb Notch-4(S), and a 9.3 kb Notch-4(L), mRNA.  Incompletely spliced Notch-4(L) potentially encodes two proteins; one is similar to the INT3 oncoprotein, the other consists of the first seven EGF repeats.  Notch-4 may have experienced segmental duplication during evolution.  The transmembrane receptor of a conserved intercellular cell fate signaling mechanism, Notch-4 protein contains twenty-nine EGF-like repeats and three Notch/lin-12 repeats in the extracellular region.  Six cdc10/ankyrin repeats, a polyglutamine domain, and a C-terminal PEST region comprise the intracellular region.  INT3 interruption of Notch-4 produces a truncated gain-of-function product that has profound consequences for mammary gland development and tumorigenesis.  (from OMIM and NCI)
C18347	EIF3S6_Gene	Translation_Process_Gene	EIF3S6 Gene|EIF3-P48|EIF3S6|Eukaryotic Translation Initiation Factor 3, Subunit 6 48kDa Gene|INT6|eIF3-p46|eIF3e	The EIF3S6 gene is a putative tumor suppressor gene, encoding the p48 subunit of EIF3, that is highly conserved evolutionarily and widely expressed.  EIF3 is the largest EIF, consisting of at least 10 non-identical subunits in mammals.  EIF3S6 is identical to the INT6 gene product, one of eight genes found genetically altered by MMTV integration in various mammary tumors.  Interruption of INT6 by MMTV integration results in a dominant-negative or biological activation of function of p48.  The human gene is located at 8q22-q23.
C18348	Oncogene_KIT	C-KIT_Gene	Oncogene KIT|Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog|KIT|PBT	Cloned cancer gene for Familial gastrointestinal stromal tumors (GIST), KIT proto-oncogene encodes a putative transmembrane receptor tyrosine kinase for stem cell factor and is critical in the development of pluripotent hematopoietic stem cells, migrating embryonic melanoblasts, and primordial germ cells.  The human proto-oncogene is located at 4q12.
C18349	Oncogene_YES-1	YES1_Gene	Oncogene YES-1|YES1|YES1 Gene	The gene product of oncogene YES-1 is associated with tyrosine kinase activity and its amino acid sequence shows high similarity with that of SRC. Multiple copies of YES-related genes occur in the human genome. Oncogene YES-1 is located at 18p11.31-p11.21.
C18350	AKT1_Gene	Serine-Threonine_Protein_Kinase_Gene	AKT1 Gene|AKT1|PKB|PRKBA|RAC|RAC-ALPHA|RAC-ALPHA Gene|RAC-PK-Alpha|v-akt Murine Thymoma Viral Oncogene Homolog 1 Gene	Human AKT1 Gene (RAC family) at 14q32.3, proximal to the Ig heavy chain loci, encodes RAC-Alpha (serine/threonine) protein kinase activated by PI3K and containing SH2-like domains, with sequence similarity to PKC and cAMP-dependent protein kinase.  In response to survival factors, AKT1 activates IKBKA, inactivates apoptotic components including BAD and caspase-9, and inactivates transcription factor FKHRL1, an activator of cell death genes.  (from SWISS-PROT, OMIM, and NCI)
C18351	WNT5A_Gene	WNT_Family_Gene	WNT5A Gene|WNT5A|Wingless-Type MMTV Integration Site Family, Member 5A Gene	Human WNT5A Gene (WNT Family) encodes 365-aa 41-kDa (precursor) WNT5A Protein, a cysteine-rich secreted glycoprotein growth factor involved in embryonic cell migration and axis induction. Frizzled-5 is a 7 transmembrane receptor for WNT5A ligand, which shows 98%, 98% and 87% amino acid identity to mouse, rat, and xenopus Wnt5A proteins. (NCI)
C18352	AKT2_Gene	Serine-Threonine_Protein_Kinase_Gene	AKT2 Gene|AKT2|PKBBETA|PRKBB|RAC-BETA|RAC-PK-Beta|v-akt MurineThymoma Viral Oncogene Homolog 2 Gene	One of two cellular homologues of the v-AKT oncogene of retrovirus AKT8, human AKT2 Gene (RAC family) at 19q13.1-q13.2 encodes PI-dependent RAC-Beta (serine/threonine) protein kinase, containing SH2-like domains, expressed in insulin-responsive tissues, and implicated in the glucose homeostatic actions of insulin.  (from SWISS-PROT, OMIM, and NCI)
C18353	WNT2_Gene	WNT_Family_Gene	WNT2 Gene|INT1L1 Gene|IRP Gene|WNT2|Wingless-Type MMTV Integration Site Family Member 2 Gene	The WNT2 gene encodes a secreted growth factor member of the INT1 gene family and is associated with breast cancer.  The human gene is located at 7q31.
C18354	ARAF1_Gene	Serine-Threonine_Protein_Kinase_Gene	ARAF Gene|ARAF1|ARAF1 Gene|PKS|PKS2|RAFA1|v-raf Murine Sarcoma 3611 Viral Oncogene Homolog 1	Human ARAF1 Gene (MIL/RAF family) at Xp11.4-p11.2, 10-17 cM proximal to the HPRT gene, encodes a cytoplasmic A-RAF serine/threonine protein kinase, containing a DAG binding domain and involved in transduction of mitogenic signals from cell membrane to nucleus.  A 2.4 kb mRNA is produced, which comprises sixteen exons spanning by a minimum of 10.8 kb.  In mouse, ARAF1 is expressed predominantly in urogenital tissues.  (from SWISS-PROT, OMIM, and NCI)
C18355	WNT1_Gene	WNT_Family_Gene	WNT1 Gene|INT1|MMTV Integration Site Gene 1|WNT1|Wingless-Type MMTV Integration Site Family, Member 1 Gene	The WNT1 gene encodes INT1/WNT1, a cysteine-rich putative secreted glycoprotein homologous to the Drosophila segment polarity gene wingless product.  It is probably a signaling protein acting in CNS mesencephalic and metencephalic development.  The human gene is located at 12q13.
C18356	ARHA_Gene	G_Protein_Gene	RHOA Gene|ARH12|ARHA|Aplysia Ras-Related Homolog 12|H12|RAS Homolog Gene Family, Member A|RHOA|RHOH12|Ras Homolog Gene Family, Member A (Oncogene RHO H12)|Rho12	Human ARHA Gene at 3p21.3 encodes a RHO GTPase member of the RAS-related GTP-binding protein family.  RHOA is a small guanosine triphosphatase that regulates remodeling of the actin cytoskeleton during cell morphogenesis and motility.  Active RHOA signals its downstream effector ROCK1 to phosphorylate and activate LIM kinase to phosphorylate cofilin, inhibiting its actin-depolymerizing activity.  (from SWISS-PROT, OMIM, and NCI)
C18357	ARHB_Gene	G_Protein_Gene	RHOB Gene|ARH6|ARHB|RAS Homolog Gene Family, Member B|RHOB|RHOH6	Human ARHB Gene at 2pter-p12 encodes a RHO GTPase member of the RAS-related GTP-binding protein family.  RHOB is a small guanosine triphosphatase that regulates remodeling of the actin cytoskeleton during cell morphogenesis and motility.  Phosphorylated and activated by ROCK, an effector of RHOB, LIM kinase phosphorylates cofilin, inhibiting its actin-depolymerizing activity.  (from SWISS-PROT, OMIM, and NCI)
C18358	ARHC_Gene	G_Protein_Gene	RHOC Gene|ARH9|ARHC|Aplysia RAS-Related Homolog 9|RAS Homolog Gene Family, Member C|RHOC|RHOH9	Human ARHC Gene at 1p21-p13 encodes a RHO GTPase member of the RAS-related GTP-binding protein family.  RHOC is a small guanosine triphosphatase that regulates remodeling of the actin cytoskeleton during cell morphogenesis and motility.  Active RHOC signals its downstream effector ROCK1 to phosphorylate and activate LIM kinase to phosphorylate cofilin, inhibiting its actin-depolymerizing activity.  RHOC is important in tumor cell invasion. (from SWISS-PROT, OMIM, and NCI)
C18359	AXL_Gene	Receptor_Tyrosine_Kinase_Gene	AXL Gene|AXL|AXL Receptor Tyrosine Kinase Gene|UFO Gene	Human AXL Gene (AXL/UFO family) at 19q13.1-q13.2 is transcribed into a 5.0 kb and a 3.2 kb mRNA that encodes a conserved transmembrane GAS6 receptor tyrosine kinase with a novel structure.  AXL is widely expressed in mouse monocytes and macrophages, but not in B- or T-lymphocytes.  The cellular function of AXL in non-transformed cells is unclear.  AXL was originally identified as an oncogene (due to over expression) in two chronic myelogenous leukemia patients.  (from SWISS-PROT, OMIM, and NCI)
C18360	BCL3_Gene	Transcription_Factor_Gene	BCL3 Gene|B-Cell CLL/Lymphoma 3 Gene|BCL3|BCL4|D19S38	The BCL3 Gene was originally identified as a gene located in the breakpoint region of t(14;19)(q32;13.1), also involving the Ig gene region, in a patient with chronic lymphocytic leukemia.  A possible transcription activating factor containing ankyrin repeats, BCL3 is activated by phosphorylation and functions as an IKB specific for p50/NFKB homodimers, inhibiting nuclear translocation.  BCL3 confers a survival advantage to T-cells, possibly by promoting the expression of genes repressed by NFKB members such as REL.  The human gene is located at 19q13.
C18361	VAV2_Gene	VAV_Family_Gene	VAV2 Gene|VAV 2 Oncogene Gene|VAV2	The VAV2 oncogene encodes VAV2, of the VAV oncoprotein family, which acts as a guanosine nucleotide exchange factor (GEF) for RHOG and RHOA-like GTPases.  Integrin-induced phosphorylation of VAV2 requires SYK.  VAV2 contains a calponin-homology domain, a DBL-homology domain, a PH domain, a DAG binding domain, an SH2 domain, and SH3 domains.  The human gene is located at 9q34.1.
C18362	BMI1_Gene	Transcription_Factor_Gene	PCGF4 Gene|BMI1|BMI1 Gene|PCGF4|Polycomb Group Ring Finger 4 Gene	Originally identified by provirus tagging in mice as an oncogene that synergizes with MYC in pre-B cell lymphomagenesis, the BMI1 gene encodes a highly conserved nuclear protein containing a novel putative zinc finger and a domain of homology to a Drosophila Polycomb protein.  BMI1 appears to be a member of a vertebrate Polycomb complex that regulates segmental identity by repressing HOX genes throughout development.  BMI1 and RING1 may be part of a protein complex.  The human gene is located at 10p11.23.
C18363	BRAF_Gene	Serine-Threonine_Protein_Kinase_Gene	BRAF Gene|B-raf-1|BRAF|RAFB1|v-raf Murine Sarcoma Viral Oncogene Homolog B1	A homologue of the avian c-Rmil protooncogene, human BRAF Gene (MIL/RAF Family) at 7q34 encodes a 94 kD serine/threonine kinase signaling factor critical in formation of the vascular system.  Avian BRAF sequences are encoded by three exons, which are conserved in human BRAF.  Fusion of TIF1A to BRAF by chromosomal translocation results in production of a TIF1-Alpha-B-RAF oncoprotein.  (from SWISS-PROT, OMIM, and NCI)
C18364	CBL_Gene	Signaling_Pathway_Gene	CBL Gene|CBL|CBL2|Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence	The CBL gene, cellular homologue of v-cbl, is expressed in a range of hematopoietic lineages and encodes adaptor protein CBL, containing a RING finger and multiple SH3 domains, a protein similar to SLI1, a negative regulator of an EGF receptor tyrosine kinase homologue.  Through its SH2 domain, CBL regulates activated tyrosine-phosphorylated receptor PTK ubiquitination as an E3 ubiquitin ligase and recruits, and activates, an E2 ubiquitin-conjugating enzyme through its RING domain.  CBL is recruited to the tyrosine kinase insulin receptor by CAP adaptor protein, through a CAP SH3 domain.  Upon CBL phosphorylation, CAP/CBL dissociates from the receptor to complex with caveolar flotillin and localize to plasma membrane lipid rafts.  Malignancies are associated with translocations of CBL.  The human gene is located at 11q23.3.(LocusLink)
C18365	VAV1_Gene	VAV_Family_Gene	VAV1 Gene|VAV 1 Oncogene Gene|VAV1	VAV plays a role in T- and B-cell development and activation.
C18366	TP73_Gene	Apoptosis_Regulation_Gene	TP73 Gene|TP73|Tumor Protein p73 Gene	The tumor suppressor TP73 gene encodes a 73 kD protein with sequence similarity to p53.  p53 residues implicated in DNA binding are conserved in p73, which appears to activate some p53-responsive genes and to induce apoptosis.  p73 and c-ABL may participate in a mismatch repair-dependent pro-apoptotic signaling pathway.  p73 and c-ABL associate through interaction of a c-ABL SH3 domain with a p73 PXXP motif in the C-terminal homooligomerization domain.  p73 is a c-ABL kinase substrate; p73 phosphorylation is enhanced by gamma-irradiation.  c-ABL stimulates p73-mediated transactivation and apoptosis.  T-cells undergoing TCR-AICD, in a late G1 cell-cycle checkpoint, are dependent on E2F1 and TP73.  Expression of E2F1 causes accumulation of p73.  The human gene is located at 1p36.
C18367	TP53BP2_Gene	Ligand_Binding_Protein_Gene	TP53BP2 Gene|TP53BP2|Tumor Protein P53 Binding Protein, 2 Gene|Tumor Protein P53-Binding Protein-2 Gene	The TP53BP2 gene encodes a protein that binds to the p53 tumor suppressor protein and interacts with BCL2.  TP53BP2 does not induce apoptosis but does impede cell cycle progression beyond G2/M.  The TP53BP2 SH3 domain and ankyrin repeats are required for interaction with p53 and with BCL2; TP53BP2 cannot bind to both proteins simultaneously.  TP53BP2 enhances p53 DNA binding and transactivation of pro-apoptotic genes, such as p21CDKN1A.  The human gene is located at 1q42.1.
C18368	TNF_Gene	Growth_Factor_Gene	TNF Gene|DIF|TNF|TNF A|TNFSF2|Tumor Necrosis Factor (TNF Superfamily, Member 2) Gene|Tumor Necrosis Factor Gene	The TNF gene encodes tumor necrosis factor, a multifunctional pro-inflammatory cytokine with effects on lipid metabolism, coagulation, insulin resistance, and endothelial function.  Activated macrophages constitute the major cellular origin of TNF. TNF alpha and TNF beta share a common receptor on tumor cells and are up regulated by gamma-interferon.  TNFA stimulates prolonged expression of the JUN oncogene.  The human gene is located at 6p21.3.
C18369	Oncogene_TIM	ARHGEF5_Gene	Oncogene TIM|Guanine nucleotide regulatory protein TIM gene|Rho guanine nucleotide exchange factor 5 gene|Transforming immortalized mammary oncogene	Oncogene TIM encodes a predicted 60 kD protein containing a DBL homology domain, shared by several signal transducing regulators of small GTP-binding proteins. TIM is thought to control cytoskeletal organization through regulation of small GTP-binding proteins. The human gene is located at 7q33-q35.
C18370	TIAM1_Gene	Signaling_Pathway_Gene	TIAM1 Gene|T-Cell Lymphoma Invasion and Metastasis 1 Gene|TIAM1	The TIAM1 gene encodes a serine-rich protein that contains a DBL homology (DH) domain, a PDZ/DHR domain, and two pleckstrin-homologous (PH) domains.  The DH domain is found in GDP-GTP exchanger proteins that activate RHO-like GTPases and PH domains are thought to be involved in protein-protein interactions.  TIAM1 appears to modulate activation of the GDP-GTP exchange activity of RHO-like GTPases that regulate cytoskeletal organization.  TIAM1 activates RAC1, CDC42, and to a lesser extent RHOA.  The human gene is located at 21q22.1.
C18371	CDKN1C_Gene	Cyclin-Dependent_Kinase_Inhibitor_Gene	CDKN1C Gene|BWCR|BWS|CDKN1C|Cyclin-Dependent Kinase Inhibitor 1C Gene|KIP2|KIP2 Gene|P57-Kip2 Gene|WBS|p57	The tumor suppressor candidate CDKN1C gene encodes cyclin-dependent kinase inhibitor 1C (p57(KIP2) containing an N-terminal CDK inhibitory domain with significant similarity to p21(CIP1).  p57(KIP2) protein is a potent tight-binding inhibitor of several G1 cyclin/CDK complexes and a negative regulator of cell proliferation.  The human gene is located at 11p15.5.
C18372	CHES1_Gene	Transcription_Factor_Gene	CHES1 Gene|CHES1|CHK1|Checkpoint Suppressor 1 Gene|FOXN3	The CHES1 gene encodes CHES1 protein, a member of the forkhead family of transcription factors.  Originally isolated from a human glioblastoma cDNA library, it suppresses S. cerevisiae checkpoint mutations.  CHES1 may function in DNA damage-inducible cell cycle arrests, or checkpoints, at G1 or G2.  The human gene is located at 14q24.3-q31.
C18373	MAP3K8_Gene	Serine-Threonine_Protein_Kinase_Gene	MAP3K8 Gene|COT|COT (Cancer Osaka Thyroid) Oncogene|COT Gene|Cancer Osaka Thyroid Gene|Cancer Osaka Thyroid Oncogene|EST|ESTF|MAP3K8|Mitogen-Activated Protein Kinase 8 Gene|Proto-Oncogene Serine/Threoine Protein Kinase Gene|TPL-2|Tumor Progression Locus-2|c-COT	The 8-exon 28-kb human MAP3K8 Gene (MAP3K Family) at 10p12.1 encodes cytoplasmic 58-kD (S and G2/M phase specific) and 52-kD isoforms of (Ser/Thr) MAP Kinase Kinase Kinase 8, produced by alternative initiation, that activates MAP kinase and JNK kinase pathways in cell cycle regulation. Ser/Thr and autophosphorylated p38 MAPK activates IKB kinases, inducing proteasome-mediated proteolysis of cytoplasmic NFKB and nuclear translocation, and promotes TNF-alpha and IL-2 production during T lymphocyte activation. (NCI)
C18374	CRK_Gene	Transcription_Factor_Gene	CRK Gene|CRK|v-CRK Sarcoma Virus CT10 Oncogene Homolog (Avian) Gene	The CRK gene is the homologue of the transforming oncogene of the avian sarcoma virus CT10.  The encoded protein contains SH2 and SH3 homology domains.  The gene maps to a region of chromosome 17p presumed to harbor a tumor suppressor gene.  CRK interacts with ABL via SH2 and SH3 domains.  The human gene is located at 17p13.3.
C18375	CRKL_Gene	Non-Receptor_Tyrosine_Kinase_Gene	CRKL Gene|CRKL|V-Crk Sarcoma Virus CT10 Oncogene Homolog (Avian)-Like Gene	The CRKL gene, an oncogene transduced by the avian sarcoma virus CT10, encodes a non-receptor tyrosine kinase similar to CRK, and to other protein tyrosine kinases with SH2 and SH3 domains.  CRKL appears to activate RAS-dependent and JNK pathways.  CRKL appears to be a substrate for the BCR-ABL tyrosine kinase.  The human gene is located at 22q11.
C18376	D10S170	Gene_with_Unknown_or_Unclassified_Function	CCDC6 Gene|CCDC6|Coiled-Coil Domain Containing 6 Gene|D10S170|H4|H4 Gene|H4 Proto-Oncogene|PTC|TPC|TST1	One of three loci rearranged with the RET gene in papillary thyroid carcinomas, human H4 Gene at 10q21 has no known function and shows no homology to any known gene.  A putative N-terminal leucine zipper mediates H4 protein dimerization.  (from OMIM and NCI)
C18377	THRB_Gene	Thyroid_Hormone_Receptor_Gene	THRB Gene|ERBA2|THR1|THRB|THRB1|THRB2|Thyroid Hormone Receptor Beta Gene|Thyroid Hormone Receptor, Beta (Erythroblastic Leukemia Viral (V-ERB-A) Oncogene Homolog 2, Avian) Gene	The THRB gene is a retrovirus-associated erbA DNA sequence originally isolated from the avian erythroblastosis virus.  The erbA-related proto-oncogenes encode thyroid hormone receptors.  Multiple high-affinity thyroid hormone receptors may bind to DNA and activate transcription and there may be as many as five thyroid hormone receptor-encoding loci in the human genome.  Two distinct ERBA proto-oncogenes have been identified, ERBA-alpha and ERBA-beta, each giving rise to at least two proteins.  THRB2 (ERBA-beta) is a thyroid hormone receptor transcription factor present in liver, heart, and brain.  The human gene is located at 3p24.
C18378	DDX6_Gene	Helicase_Gene	DDX6 Gene|ATP-Dependent RNA Helicase p54 Gene|DDX6|DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 6 Gene|DEAD/H Box 6 Gene|HLR2|Helicase, RNA, Nuclear 2 Gene|RCK|p54	The DDX6 gene encodes DEAD/H BOX 6, a putative RNA helicase/translation initiation factor, associated with hematopoietic tumors containing 11q23 translocations.  DEAD box proteins are putative RNA helicases that have a characteristic Asp-Glu-Ala-Asp (DEAD) box as one of eight highly conserved sequence motifs.  The human gene is located at 11q23.3.
C18379	E2F1_Gene	Transcription_Factor_Gene	E2F1 Gene|E2F Transcription Factor 1 Gene|E2F-1|E2F1|RBBP3|RBP3	The E2F1 gene at 20q11.2 encodes E2F1, which binds DNA as homo- or heterodimers with DP1 or DP2. E2F1 transactivates p53 and p73. MYC-induced apoptosis involves E2F1. E2F1 can induce apoptosis in a p53-independent manner through accumulation of p73 or through a death receptor-dependent mechanism by down regulating TRAF2 and inhibiting activation of NFKB anti-apoptotic signals. E2F1 also induces p53-dependent apoptosis by inducing ARF, which neutralizes MDM2 and stabilizes p53. TCR-AICD, in a p53-independent late G1 phase cell-cycle checkpoint, is dependent on E2F1 and TP73. E2F is a critical determinant of G1/S transition, activating transcription of genes necessary for DNA replication. RB interacts with E2F factors to arrest cells in G1 by active transcriptional repression. RB-E2F repression mediates G1 arrest triggered by TGFB, by p16, and by contact inhibition. Accumulation of G1 cyclins E and D1 is regulated by E2F1. (from OMIM 189971 and NCI)
C18380	THRA_Gene	Thyroid_Hormone_Receptor_Gene	THRA Gene|ERBA1|THRA|THRA1|THRA2|Thyroid Hormone Receptor Alpha Gene|Thyroid Hormone Receptor, Alpha (Erythroblastic Leukemia Viral (V-ERB-A) Oncogene Homolog, Avian) Gene	The THRA gene is a retrovirus-associated erbA DNA sequence originally isolated from the avian erythroblastosis virus.  The erbA-related proto-oncogenes encode thyroid hormone receptors.  Evidence indicates the presence of many high-affinity thyroid hormone receptors that activate transcription and perhaps as many as five receptor-encoding loci in the human genome.  Two ERBA proto-oncogenes have been identified, ERBA-alpha (ERBA1) and ERBA-beta (ERBA2), giving rise to at least two proteins each.  ERBA1 encodes ERBA alpha-1, and ERBA alpha-2 by alternative splicing.  THRA1 (ERBA-alpha1) is expressed in many tissues, with highest levels in the central nervous system and no expression in the liver.  THRA2 (ERBA-alpha2) is expressed in liver, kidney, placenta, and brain.  The human gene is located at 17q21.
C18381	NCOA4_Gene	Nuclear_Receptor_Coactivator_Gene	NCOA4 Gene|ARA70 Gene|Androgen Receptor Coactivator Gene, 70-kD|ELE1 Gene|NCOA4|Nuclear Receptor Coactivator 4 Gene|RET-Activating Gene|RFG Gene	The proto-oncogene NCOA4 encodes ARA(70), a ligand-dependent co-activator protein that enhances specific androgen receptor transcriptional activity.  Illegitimate recombination with the RET gene results in the RET/PTC3 oncogene, a tumor specific rearrangement of the RET gene detected in papillary thyroid carcinomas.  The androgen receptor is a transcription factor of the steroid receptor superfamily.  Although several steroid-class receptors recognize the same DNA regulatory sequence, gene-specific activation may be achieved by selective accessory factors that interact with the receptors to determine specificity of target gene activation.
C18382	EMS1_Gene	Ligand_Binding_Protein_Gene	CTTN Gene|CTTN|Cortactin Gene|EMS1	Human EMS1 Gene at 11q13 encodes variants of cytoplasmic Cortactin, an actin-binding protein involved in restructuring the cortical cytoskeleton and organizing epithelial cell structure. Like murine Cttn, Cortactin is located in cell-substratum contact areas and contains one SH3 domain that may bind to the cytoskeleton. It also regulates interactions between adherens junction components. It may interact with SHANK2 and SHANK3 via its SH2 domain. As a pp60v-SRC substrate, Cortactin phosphorylation may regulate cell growth. EGF enhances p80 to p85 conversion by phosphorylation. Posttranslational modification of Cortactin coincides with redistribution to cell-matrix contact sites. Caspase-dependent degradation of Cortactin occurs during apoptosis. Aberrant gene regulation contributes to tumor cell invasion and metastasis. (from Swiss-Prot Q14247, OMIM 164765, and NCI)
C18383	EPHA1_Gene	Receptor_Tyrosine_Kinase_Gene	EPHA1 Gene|EPH Gene|EPH Receptor A1 Gene|EPH Tyrosine Kinase 1 Gene|EPHA1|EPHT|EPHT1	Human EPHA1 Gene (EPH Family) at 7q32-q36 encodes ephrin receptor EPHA1, a tyrosine kinase implicated in nervous system development, and elsewhere.  Exon splice sites for the kinase domain are distinct from other tyrosine kinase genes, suggesting an early evolutionary split.  EPHA1 mRNA is detected in rat liver, lung, kidney, and testes; human expression appears to be preferential for epithelial cells.  Axonal EPHA receptors interact with ephrin-A ligands, anchored to the plasma membrane by glycosylphosphatidylinositol linkage.  Over expression has been found in hepatoma and lung cancer without gene amplification.  (from SWISS-PROT, OMIM, and NCI)
C18384	EPHA3_Gene	Receptor_Tyrosine_Kinase_Gene	EPHA3 Gene|EPH Receptor A3 Gene|EPH-Like Tyrosine Kinase 1 Gene|EPHA3|ETK|ETK1|HEK|HEK Gene|HEK4|Human Embryo Kinase Gene|TYRO4	Human EPHA3 Gene (EPH Family) at 3p11.2 encodes EPHA3 ephrin receptor tyrosine kinase.  Expressed as a single transcript in a variety of human tissues, EPHA3 may play a role in some human lymphoid malignancies and in normal lymphoid function and differentiation.  EPH receptors typically have a single kinase domain and an extracellular region containing a cysteine-rich domain and two fibronectin type III repeats.  EPHA receptors interact preferentially with ephrin-A proteins, ligands anchored to the plasma membrane by glycosylphosphatidylinositol linkage. (from SWISS-PROT, OMIM, and NCI)
C18385	NR2F6_Gene	Nuclear_Receptor_Gene	NR2F6 Gene|EAR-2 Gene|EAR2 Gene|ERBAL2 Gene|NR2F6|Nuclear Receptor Subfamily 2, Group F, Member 6 Gene	Highly expressed in fetal liver, human NR2F6 Gene (NR2 family) on chromosome 19 encodes EAR2, containing a DNA-binding domain and similar in primary structure to receptors for steroid and thyroid hormones. (from SWISS-PROT, OMIM, and NCI)
C18386	ERBB3_Gene	Receptor_Gene	ERBB3 Gene|EGF Receptor 3 Gene|ERBB3|HER3|V-ERB-B2 Erythroblastic Leukemia Viral Oncogene Homolog 3 (Avian) Gene	Human ERBB3 Gene (ERBB Family) at 12q13 encodes EGFR3, a predicted 148 kD transmembrane polypeptide related to but distinct from EGFR, ERBB2, and ERBB4.  A 6 kb transcript is found in various tissues.  ERBB2, ERBB3, and ERBB4 encode homo- and heterodimeric heregulin/neuregulin receptors.  ERBB3 is capable of mediating HGL-stimulated tyrosine autophosphorylation.  Elevated transcript levels are seen in certain mammary tumor cell lines, suggesting a role in some malignancies.  The gene is frequently over expressed in solid tumors, including breast cancer. (from SWISS-PROT, OMIM, and NCI)
C18387	SUPT3H_Gene	Transcription_Factor_Gene	SUPT3H Gene|SPT3|SPT3L|SUPT3H|Suppressor of Ty 3 Homolog|Suppressor of Ty 3 Homolog (S. Cerevisiae) Gene	The SUPT3H gene is an homologue of the yeast Spt3 gene, a transcription factor required for expression of many RNA polymerase II-transcribed genes.  The SUPT3H gene product is a subunit of the P/CAF complex.  The human gene is located at 6p21.1-p21.3.
C18388	ERBB4_Gene	Receptor_Tyrosine_Kinase_Gene	ERBB4 Gene|ERBB-4|ERBB4|HER-4|HER4|NDF/Heregulin Receptor Gene|V-ERB-A Erythroblastic Leukemia Viral Oncogene Homolog 4 (Avian) gene	Human ERBB4 Gene (ERBB Family) at 2q33.3-q34 encodes HER4/ERBB4, an EGFR-related type I receptor tyrosine kinase.  Like EGFR, ERBB2, and ERBB3, ERBB4 is located in close proximity to homeobox and collagen gene loci.  ERBB2, ERBB3, and ERBB4 encode homo- and heterodimeric heregulin/neuregulin receptors.  ERBB4 is enriched in the post-synaptic density, associates with PSD95 (which may facilitate ERBB4 dimerization), and appears to enhance NRG activation of ERBB4 and MAP kinase.  NRG/ERBB4 signaling in the adult central nervous system may modulate synaptic plasticity.  ERBB4 is frequently over expressed in solid tumors, including breast cancer. (from SWISS-PROT, OMIM, and NCI)
C18389	SUPT5H_Gene	Transcription_Factor_Gene	SUPT5H Gene|SPT5H|SUPT5H|Suppressor of Ty 5 Homolog|Suppressor of Ty 5 Homolog (S. Cerevisiae) Gene	The SUPT5H gene is an homologue of the Spt5 gene, a yeast transcription factor.  Highly acidic and reversibly phosphorylated during mitosis, SUPT5H contains MAP kinase consensus sequences and is believed to be part of a chromatin modulating complex involved in transcriptional repression.  Also, a possible homologue of zebrafish 'foggy', which affects neuronal development.  Foggy is not part of the transcription apparatus, but a phosphorylation-dependent dual regulator of transcription elongation.  The human gene is located at 19q13.1-q13.2.
C18390	SUPT6H_Gene	Transcription_Factor_Gene	SUPT6H Gene|KIAA0162|SPT6H|SUPT6H|Suppressor of Ty 6 Homolog|Suppressor of Ty 6 Homolog (S. Cerevisiae) Gene	The SUPT6H gene is an homologue of the yeast Spt6 gene, a chromatin structure regulator.  SUPT6H has features consistent with a nuclear protein that regulates transcription: a highly acidic 5-prime region, a degenerate SH2 domain, and a leucine zipper.  SUPT6H may regulate transcription through establishment or maintenance of chromatin structure.  The human gene is located at 17q11.2.
C18391	ETV3_Gene	ETS_Family_Gene	ETV3 Gene|ETS Variant Gene 3|ETS Variant Gene 3 Gene|ETV3|PE-1|PE1	Human ETV3 Gene (ETS Family) at 1q21-q23 encodes a transcription factor with the conserved ETS domain motif, which mediates sequence-specific DNA binding.  (from SWISS-PROT, OMIM, and NCI)
C18392	EVI1_Gene	Transcription_Factor_Gene	EVI1 Gene|EVI1|Ecotropic Viral Integration Site 1|MDS1-EVI1|PRDM3	Human EVI1 Gene at 3q26 encodes a protein with multiple zinc-finger repeats common in transcriptional regulatory proteins.  Activation by retroviral insertion is frequently found in murine myeloid leukemias and leukemia cell lines.  (from SWISS-PROT, OMIM, and NCI)
C18393	Oncogene_SPI1	SPI1_Gene	Oncogene SPI1|Spleen Focus Forming Virus Proviral Integration Oncogene SPI1	SPI1 is an oncogene specifically activated in acute murine erythroleukemias, induced by the Friend spleen focus forming virus.  It encodes the transcription factor PU.1, normally expressed in all hematopoietic lineages except in T-cells. An ETS-domain transcription factor essential for the development of myeloid (osteoclast progenitors) and B-lymphoid cells. Graded expression of this transcription factor appears to specify distinct cell fates in the hematopoietic system. A low concentration of PU.1 protein induces the B-cell fate, whereas a high concentration promotes macrophage differentiation. PU.1 is thought to regulate transcription of FMS and CD18/11B, proteins central to the osteoclast phenotype, and is required for p47-phox promoter activity in myeloid cells. PU.1 expression is increased with the induction of osteoclastogenesis by 1, 25-dihydroxyvitamin D3. The human gene is located at 11p11.2.
C18394	SMARCB1_Gene	SWI-SNF-Related_Gene	SMARCB1 Gene|BAF47|BAF47 Gene|INI1|INI1 Gene|RDT|SMARCB1|SNF5|SNF5 Gene|SNF5L1|SNF5L1 Gene|SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Gene|hSNF5/INI1 Gene	The tumor suppressor SMARCB1 gene, inactivated in malignant rhabdoid tumors, encodes a member of the chromatin-remodeling SWI/SNF multi-protein complex.  The human gene is located at 22q11.2.
C18395	Proliferation_Marker	Tumor_Marker	Proliferation Marker	Refers to specific proteins or other factors in actively growing and dividing cells, whose presence serves as an indicator for such cells.  For instance, proliferating cell nuclear antigen (PCNA) or mitotic index.
C18396	Metastasis_and_Aggressiveness_Marker	Tumor_Marker	Metastasis and Aggressiveness Marker
C18397	FAT_Gene	Cell_Adhesion_Molecule_Gene	FAT Gene|CDHF7|Drosophila FAT Tumor Suppressor Homolog|FAT|FAT Tumor Suppressor Homolog 1 (Drosophila) Gene|ME5	The FAT gene encodes a homologue of the Drosophila 'fat' tumor suppressor protein, possessing 34 cadherin repeats and other characteristics.  The transmembrane protein might be involved in mammalian developmental processes and cell communication and/or adhesion.  Loss-of-function FAT mutations lead to hyperplastic overgrowth that maintains normal epithelial organization and differentiation, indicating that contact-dependent cell interactions may play an important role in regulating growth.  The human gene is located at 4q34-q35.
C18398	ERBB5_Receptor_Protein_Tyrosine_Kinase	ErbB_Receptor_Family_Protein	ERBB5 Receptor Protein Tyrosine Kinase|c-erbB-5
C18399	ROS1_Gene	Receptor_Tyrosine_Kinase_Gene	ROS1 Gene|MCF3|ROS1|V-ROS UR2 Sarcoma Virus Oncogene Homolog 1 (Avian) Gene|v-ROS Avian UR2 Sarcoma Virus Oncogene Homolog 1	This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor. (LocusLink)
C18400	CSVTCG-Specific_TSP-1_Receptor	Cell_Surface_Receptor	CSVTCG-Specific TSP-1 Receptor|CSVTCG-Specific Receptor	CSVTCG-Specific Receptor (GP IV) is the receptor for thrombospondins in platelets and various cell lines.  GP IV is also the primary receptor for platelet adhesion to collagen and mediates macrophage scavenging of senescent polymorphonuclear cells undergoing apoptosis.  GP IV binds cysteine-serine-valine-threonine-cysteine-glycine (CSVTCG).  Since thrombospondins are adhesive proteins widely distributed and involved in a variety of adhesive processes, GP IV may have important functions as a cell adhesion molecule.  (from OMIM 173510 and NCI)
C18401	RALB_Gene	G_Protein_Gene	RALB Gene|RALB|RAS-Like Protein B Gene|v-ral Simian Leukemia Viral Oncogene Homolog B	The RALB gene encodes a GTP-binding protein related to RAS.  The human gene is located at 2cen-q13.
C18402	RALA_Gene	G_Protein_Gene	RALA Gene|RAL|RALA|RAS-Like Protein A Gene|v-ral Simian Leukemia Viral Oncogene Homolog A	Human RALA Gene (RAS GTPase Family) at 7p15-p13 encodes 206-aa 24-kDa GTP-binding RAS-like RALA Protein, which interacts with RALBP1 via its effector domain and likely mediates some cell surface transmembrane receptor signaling. (NCI)
C18403	PVT1_Gene	Gene_with_Unknown_or_Unclassified_Function	PVT1 Gene|PVT1|PVT1 Oncogene Homolog, MYC Activator (Mouse) Gene	Originally defined as a mouse tumor virus integration site, the PVT1 gene is involved in some human Burkitt lymphomas.  The human gene is located at 8q24.
C18404	NFKB2_Gene	Transcription_Factor_Gene	NFKB2 Gene|LYT-10 Gene|LYT10 Gene|NFKB2|Nuclear Factor of Kappa Light Chain Gene Enhancer in B-cells 2|Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells 2 (p49/p100) Gene	Human NFKB2 Gene (Rel/Dorsal Family) encodes NF-Kappa B p49/p100, precursor of the NFKB p52 subunit containing seven ANK repeats that binds to p65REL proteins to form NFKB, trapped in the cytoplasm by IkB proteins. IkB phosphorylation by IKBKA or IKBKB activates NFKB via destructive ubiquitination of IkBs. Activated transcription factor NFKB translocates to the nucleus and binds to the consensus Kappa-B enhancer DNA motif in immune response and acute phase reaction genes. (NCI)
C18405	NMYC_Gene	MYC_Family_Gene	MYCN Gene|MYCN|NMYC|v-MYC Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived (Avian) Gene	Human v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN), located at 2p24.1, encodes the N-myc proto-oncogene protein. Amplification of this gene is associated with a variety of human tumors. In the case of neuroblastoma, there is a direct correlation between the level of MYCN amplification and tumor progression.
C18406	FER_Gene	Non-Receptor_Tyrosine_Kinase_Gene	FER Gene|FER|Fer (FPS/FES Related) Tyrosine Kinase (Phosphoprotein NCP94) Gene|TYK3	The proto-oncogene FER (FPS/FES related), encodes a tyrosine kinase expressed in lymphoid cells; phosphoprotein NCP94. Inhibition of CDH2 (cytoplasmic domain) and beta-1 integrin function results in release of FER from the cadherin complex and accumulation in the integrin complex, suggesting that FER may mediate cross-talk between CDH2 and ITGB1.  The human gene is located at 15q26.1.
C18407	LMYC_Gene	MYC_Family_Gene	MYCL1 Gene|LMYC|LMYC Gene|MYCL|v-MYC Myelocytomatosis Viral Oncogene Homolog 1, Lung Carcinoma Derived (Avian) Gene	Human v-myc myelocytomatosis viral oncogene homolog 1, lung carcinoma derived (avian) (MYCL1) gene, located at 1p34.3, encodes L-myc-1 proto-oncogene protein. This gene is amplified 10- to 20-fold in small-cell lung cancer (SCLC). Several mRNAs are produced in SCLC cells from the MYCL1 gene by alternative splicing and alternative polyadenylation signals.
C18408	FGF3_Gene	Fibroblast_Growth_Factor_Gene_Family	FGF3 Gene|FGF3|Fibroblast Growth Factor 3 (Murine Mammary Tumor Virus Integration Site (v-int-2) Oncogene Homolog) Gene|Fibroblast Growth Factor 3 Gene|INT-2|INT2|MMTV Integration Site Gene 2	Human Fibroblast Growth Factor 3 Gene (FGF family) at 11q13 contains three exons having a distinct pattern of expression throughout vertebrate development.  In mouse, FGF3 signals induction of the otic vesicle; rhombencephalic transcripts are detected when inner ear induction occurs.  (from SWISS-PROT, OMIM, and NCI)
C18409	MYBL2_Gene	Transcription_Factor_Gene	MYBL2 Gene|B-MYB|BMYB|MGC15600|MYBL2|v-MYB Myeloblastosis Viral Oncogene Homolog (Avian)-Like 2 Gene	The BMYB gene encodes a MYB family transcription factor essential during cell cycle progression.  MYBL2 transcripts are detectable in a wide variety of dividing cell types.  MYBL2 expression is regulated at the G1/S transition, and its transcription relies on E2F activity in a cell cycle-dependent manner.  MYBL2 activates CDC2 and cyclin D1 gene expression in proliferating fibroblasts.  The human gene is located at 20q13.1.
C18410	MYBL1_Gene	Transcription_Factor_Gene	MYBL1 Gene|A-MYB|AMYB|MYBL1|v-MYB Myeloblastosis Viral Oncogene Homolog (Avian)-Like 1 Gene	Expressed mainly in testis and peripheral leukocytes, human AMYB Gene (MYB family) at 8q22 encodes A-MYB Protein and may have a role in proliferation or differentiation of neurogenic, spermatogenic, and B-lymphoid cells.  In addition to three MYB-like domains, a DNA-binding domain, and a transcriptional activation domain, A-MYB contains two negative regulatory domains.  A-MYB specifically recognizes the sequence 5 prime-NAAC(G/T)G-3 prime.  (from SWISS-PROT, OMIM, and NCI)
C18411	MPL_Gene	Cytokine_Receptor_Gene	MPL Gene|C-MPL|CD110|MPL|MPLV|Myeloproliferative Leukemia Virus Oncogene|TPOR|TPOR Gene|Thrombopoietin Receptor Gene	The 17 kb human MPL Gene (HPOR family) at 1p34 encodes Thrombopoietin Receptor, a type I membrane protein with two fibronectin type III-like domains and member of the cytokine receptor superfamily.  TPO activates TPOR by inducing homodimerization and regulates production of a common progenitor of all myeloid lineages.  This progenitor expresses MPL, not IL7R; lymphoid progenitor expresses IL7R, not MPL.  Further differentiation of the myeloid progenitor depends on erythropoietin.  Defects in MPL cause congenital amegakaryocytic thrombocytopenia. (from SWISS-PROT, OMIM, and NCI)
C18412	FGF6_Gene	Fibroblast_Growth_Factor_Gene_Family	FGF6 Gene|FGF6|Fibroblast Growth Factor 6 Gene|HST-2|HST2	Distal to VWF, human Fibroblast Growth Factor 6 Gene (FGF family) at 12p13 encodes a product that exhibits strong mitogenic/angiogenic properties likely expressed by cells with platelet/megakaryocytic differentiation potential. (from SWISS-PROT, OMIM, and NCI)
C18413	FOXG1B_Gene	Transcription_Factor_Gene	FOXG1B Gene|BF1 Gene|FKH2 Gene|FKHL1|FKHL1 Gene|FKHL4 Gene|FOXB1G Gene|Forkhead Box G1B Gene|HBF-1 Gene|HFK1 Gene|QIN|QIN Gene	The Forkhead (Drosophila)-like 1 oncogene (FOXG1B) is a member of a large FKH/HNF3 family of transcription factors that share a unique highly conserved DNA-binding domain, the FKH box.  FOXG1B expression is restricted to telencephalic neurons.  The protein appears to act as a transcriptional repressor.  The human gene is located at 14q13.
C18414	FLT1_Gene	Receptor_Tyrosine_Kinase_Gene	FLT1 Gene|FLT|FLT1|FMS-Related Tyrosine Kinase 1 (Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor) Gene|FMS-Related Tyrosine Kinase 1 Gene|FRT|VEGFR1|Vascular Endothelial Growth Factor/Vascular Permeability Factor Receptor Gene	Expressed in lung, placenta, liver, kidney, heart and brain, human FLT1 Gene (CSF1R/PDGFR family) at 13q12 encodes VEGF Receptor 1, a high-affinity VEGF- and PLGF-binding type I membrane receptor tyrosine kinase important for control of cell proliferation and differentiation.  Related to ROS, FLT1 is essential for organization of the embryonic vasculature, but not for endothelial differentiation.  FLT gene structure resembles FMS.  FLT1 and FLT3, lying head-to-tail within CpG islands, are separated by about 150 kb containing a putative receptor tyrosine kinase gene.  FLT1 contains seven C2-type Ig-like domains; domains 2 and 3 mediate VEGF binding.  An alternative soluble gene product, sFLT1, binds VEGF with higher affinity than the VEGF receptor FLK1.  sFLT1 and FLK1 form heterodimers and sFLT1 may function as an inhibitor of the VEGF response.  (from SWISS-PROT, OMIM, and NCI)
C18415	FOSL1_Gene	FOS_Family_Gene	FOSL1 Gene|FOS-Like Antigen 1 Gene|FOSL1|FRA1	Human FOSL1 Gene (FOS family) at 11q13 encodes FOSL1 Protein, a transcription factor lacking transactivation domains that dimerizes with JUN family members to form AP1 transcription factor.  Osteoclast differentiation from hematopoietic precursors of the monocyte-macrophage lineage is induced by RANKL stimulation of FOSL1 transcription in a FOS-dependent manner.  (from SWISS-PROT, OMIM, and NCI)
C18416	MAFG_Gene	MAF_Family_Gene	MAFG Gene|MAFG|v-MAF Musculoaponeurotic Fibrosarcoma Oncogene Homolog G (Avian) Gene	Widely expressed human MAFG Gene (MAF family) at 17q25 contains at least three exons separated by small introns and an untranslated first exon. Highest expression of the encoded bZIP transcription factor appears in skeletal muscle.  Lacking a transactivation domain, MAFs seem to be homodimerized repressors and heterodimerized activators with other bZIP proteins.  MAFG Protein heterodimerizes with NFE2/CNC Family members: NRF1, NRF2 and p45NFE2.  NFE2 enhancers upstream of alpha- and beta-globin genes regulate globin expression and erythroid differentiation through DNA-binding of a heterodimeric MAF protein (MAFF, MAFG, or MAFK) complexed with tissue-restricted p45NFE2.  MAF proteins also heterodimerize with FOS and may repress NFE2 as well.  (from SWISS-PROT, OMIM, and NCI)
C18417	MAF_Gene	MAF_Family_Gene	MAF Gene|MAF|v-MAF Musculoaponeurotic Fibrosarcoma (Avian) Oncogene Homolog|v-MAF Musculoaponeurotic Fibrosarcoma Oncogene Homolog (Avian) Gene	Human MAF Gene (MAF family) at 16q22-q23 is a homologue of v-maf from avian musculoaponeurotic fibrosarcoma virus AS42.  Important in regulation of differentiation, MAF genes are a unique subclass of bZIP transcription factors.  Lacking a transactivation domain, MAFs seem to be homodimerized repressors and heterodimerized activators with other bZIP proteins.  MAF Protein contains a leucine zipper similar to many DNA-binding proteins.  (from OMIM and NCI)
C18418	FOSL2_Gene	FOS_Family_Gene	FOSL2 Gene|FOS-Like Antigen 2 Gene|FOSL2|FRA2	Human FOSL2 Gene (FOS family) at 2p23-p22 encodes FOSL2 Protein, a transcription factor that dimerizes with JUN family proteins to form AP1 transcription factor.  FOSL2 appears to regulate cell proliferation, differentiation, and transformation.  In some cases, expression of this gene is associated with apoptotic cell death.  (from SWISS-PROT, OMIM, and NCI)
C18419	FYN_Gene	SRC_Family_Gene	FYN Gene|FYN|FYN Oncogene Related to SRC, FGR, YES Gene|SRC/YES-Related Novel Gene|SRC/YES-Related Oncogene Homolog|SYN	Human FYN Gene (SRC family) at 6q21 encodes a 2.8 kb mRNA expressed in various cell types that produces p59FYN Protein and controls mature thymocyte proliferation.  Containing an SH2 and SH3 domain, FYN interacts with FYN-binding protein and associates, through its SH3 domain, with the p85 subunit of PI3 kinase.  (from SWISS-PROT, OMIM, and NCI)
C18420	GLI1_Gene	Retired_Concepts	GLI1 Gene
C18421	TACSTD1_Gene	Cell_Adhesion_Molecule_Gene	TACSTD1 Gene|CO17-1A|GA733-2|HGNC|KSA|LY74|M4S1|MK-1|TACSTD1|TROP1|Tumor-Associated Calcium Signal Transducer 1 Gene	The Tumor-Associated Calcium Signal Transducer 1 gene encodes a 40 kD transmembrane glycoprotein originally identified as a marker of rapidly proliferating tumors of epithelial origin.  TACSTD1 is a ligand for LAIR1, and also binds LAIR2.  TACSTD1 interacts with the LAIRs through its first EGF-like repeat.  Through its interaction with the LAIR1 inhibitory receptor, TACSTD1 may be involved in preventing excessive inflammatory responses in regions, such as intestine, with high antigen exposure.  The human gene is located at 4q.
C18422	GLI2_Gene	GLI_Family_Gene	GLI2 Gene|GLI-Kruppel Family Member 2|GLI-Kruppel Family Member GLI2 Gene|GLI2|THP	Human GLI2 Gene (GLI/Kr family) at 2q14 encodes GLI2 Protein, a homologue of Ci (Drosophila).  Alpha, beta, gamma, and delta isoforms are produced by alternative splicing.  Containing five DNA-binding C2H2 zinc finger repeats, GLI2 binds to 5 prime-GAACCACCCA-3 prime DNA and activates transcription of SHH signaling gene targets.  Mutations in GLI genes may involve foregut developmental malformations and development of BCC.  (from SWISS-PROT, OMIM, and NCI)
C18423	LYN_Gene	SRC_Family_Gene	LYN Gene|JTK8|LYN|v-YES-1 Yamaguchi Sarcoma Viral Related Oncogene Homolog	Human LYN Gene (SRC family) at 8q13 encodes p53/56LYN, containing an SH2 and SH3 domain and similar to SRC protein tyrosine kinases in the catalytic domain.  LYNA and LYNB isoforms are produced by alternative splicing.  A 3.2 kb mRNA is expressed in fetal tissues different from related genes, such as YES.  LYN appears to play a role in FCER signaling and in Ig-mediated signaling, particularly in B-cell tolerance.  LYN is essential in ITIM-dependent signaling and for activation of protein tyrosine phosphatases in myeloid cells.  Disruptions of LYN display abnormalities in B-lymphocyte lineage and mast cell function.  (from SWISS-PROT, OMIM, and NCI)
C18424	LTA_Gene	Growth_Factor_Gene	LTA Gene|LT|LTA|Lymphotoxin Alpha (TNF Superfamily, Member 1) Gene|Lymphotoxin-Alpha Gene|TNFB|Tumor Necrosis Factor, Beta Gene	Human LTA Gene (TNF family) at 6p21.3 encodes TNF Beta, a glycoprotein cytokine of activated lymphocytes having cytotoxic and necrotic effects.  Between C4 and HLA-B in the MHC region, TNFC resides just centromeric to TNFA, which is just centromeric to TNFB.  These three similar genes lie about 200 kb from HLA-B.  TNFC transcribes telomerically, TNFB and TNFA centromerically.  MHC polymorphic microsatellites within a 12 kb region include TNFB.  A putative immune response modulator similar to TNF Alpha, homotrimeric TNF Beta shares TNFR-1 and -2 receptors with TNF Alpha.  Involved in immunologic cell-cell contact reactions as well, TNFB associates in a heterotrimeric complex with a 33 kD TNFC type II membrane glycoprotein anchor on activated T, B, and LAK cells.  Composed of one TNFB and two TNFC subunits, the complex binds to TNFR-Related Protein, rather than TNFR-1 or -2.  (from SWISS-PROT, OMIM, and NCI)
C18425	LTB_Gene	Growth_Factor_Gene	LTB Gene|LTB|Lymphotoxin B Gene|Lymphotoxin Beta (TNF Superfamily, Member 3) Gene|Lymphotoxin Beta Gene|TNFC|Tumor Necrosis Factor C Gene	Human LTB Gene (TNF family) at 6p21.3 encodes TNFC, a 33 kD type II membrane glycoprotein with homology to TNF Alpha, TNF Beta, and CD40 ligand.  Between C4 and HLA-B in the MHC region, TNFC resides just centromeric to TNFA, which is just centromeric to TNFB.  These three similar genes lie about 200 kb from HLA-B.  TNFC is flanked by B144 and 1C7 on one side and by IKBL and BAT1 on the other.  TNFC transcribes telomerically, TNFB and TNFA centromerically.  Two isoforms are produced by alternative splicing.  Involved in immunologic cell-cell contact reactions, TNFC associates as a membrane anchor in a heterotrimeric complex with TNFB on activated T, B, and LAK cells.  Composed of one TNFB and two TNFC subunits, the complex binds to TNFR-Related Protein.  A homotrimeric TNFC has not been identified.  (from SWISS-PROT, OMIM, and NCI)
C18426	CXCL2_Gene	CXC_Cytokine_Gene	CXCL2 Gene|CINC-2A|CXCL2|Chemokine (C-X-C Motif) Ligand 2 Gene|GRO2|GROb|MGSA-b|MIP-2A|MIP2|MIP2A|Macrophage Inflammatory Protein 2 Gene|SCYA|SCYB2	Related to GRO1 and GRO3, human GRO2 Gene (CXC family) at 4q12-q13 encodes CXC chemokine MIP-2 Alpha, a homologue of murine MIP-2, a chemotactic agent for polymorphonuclear leukocytes.  These genes exhibit regulation by inducing agents and tissue-specific regulation.  Produced by activated monocytes and neutrophils at inflammation sites, GRO2 is regulated by IL1, TNF, and lipopolysaccharide.  It consists of four exons and a 3-prime terminal 700 base pair untranslated region where significant differences are found among GRO genes, including numbers of ATTTA repeats associated with mRNA stability.  Proline substitution in GRO1 by leucine in GRO2 and GRO3 leads to a large predicted change in protein conformation.  Acting through a G protein coupled receptor, MIP-2 Alpha affects the central nervous system and endothelial cells involved in angiogenesis or angiostasis.  (from SWISS-PROT, OMIM, and NCI)
C18427	CXCL3_Gene	CXC_Cytokine_Gene	CXCL3 Gene|CINC-2|CINC-2b|CXCL3|Chemokine (C-X-C Motif) Ligand 3 Gene|GRO3|GROg|MIP-2B|MIP2B|SCYB3	Related to GRO1 and GRO2, human GRO3 Gene (CXC family) at 4q12-q13 encodes CXC chemokine MIP-2 Beta, a homologue of murine MIP-2, a chemotactic agent for polymorphonuclear leukocytes.  These genes exhibit regulation by specific inducing agents and tissue-specific regulation.  Significant differences are found in the 3-prime untranslated region, including numbers of ATTTA repeats associated with mRNA stability.  Proline substitution in GRO1 by leucine in GRO2 and GRO3 leads to a large predicted change in protein conformation.  Acting through a G protein coupled receptor, MIP-2 beta may play a role in inflammation, exert autocrine angiogenic or angiostatic effects on endothelial cells, and affect the central nervous system.  (from SWISS-PROT, OMIM, and NCI)
C18428	JUND_Gene	JUN_Family_Gene	JUND Gene|JUN D Proto-oncogene|JUND	Located about 27 kb proximal to PDE4C, human JUND Gene (JUN family) at 19p13.1-p12 is a metastasis suppressor gene that contains no introns and encodes JUND Protein, a bZIP DNA-binding transcription factor.  The most broadly expressed JUN family member of the AP1 transcription factor complex, JUND Protein binds the AP1 site as a dimer to stimulate promoter activity and may protect cells from senescence, or apoptotic responses to stress, by acting as a modulator of the signaling pathways that link RAS to p53.  (from SWISS-PROT, OMIM, and NCI)
C18429	JUNB_Gene	JUN_Family_Gene	JUNB Gene|JUN B Proto-Oncogene|JUNB	Human JUNB Gene (JUN family) at 19p13.2 encodes JUNB Protein, a bZIP transcription factor that binds to TGAC/GTCA DNA as a homodimer or heterodimer with other JUN/FOS family members, constituting the AP1 transcription factor complex.  JUNB regulates gene activity in the primary response to growth factors.  JUN and JUNB appear to have antagonistic functions; JUNB restores the expression of genes regulated by JUN/FOS, but not those regulated by JUN/ATF.  (from SWISS-PROT, OMIM, and NCI)
C18430	IRF4_Gene	Transcription_Coactivator_Gene	IRF4 Gene|IRF4|Interferon Regulatory Factor 4 Gene|LSIRF Gene|MUM1 Gene|Multiple Myeloma Oncogene 1	Member of a gene family active in B-cell proliferation and differentiation, human IRF4 Gene (MUM/IRF family) at 6p25-p23 encodes Interferon Regulatory Factor 4, a transcription factor that binds interferon-stimulated response elements of the MHC class I promoter.  It is induced after TCR activation in T-cells.  A 5 kb transcript is expressed in spleen, lymphocytes, and melanocytes.  Two isoforms differing by one glutamate residue are produced by alternative splicing.  IRF4 also binds with PU.1 to the Ig lambda light chain enhancer.  IRF4 may participate in lymphoid cell ISRE-targeted signal transduction. (from SWISS-PROT, OMIM, and NCI)
C18431	Oncogene_Transcription_Factor	Oncogene	Oncogene, Transcription Factor|Oncogenes, Transcription Factors	Transcription factors that are encoded by oncogenes, a type of gene that contributes to the development of the malignant phenotype of a cell. Transcription factors interact with specific DNA sequences or DNA-binding proteins to initiate, stimulate, inhibit or terminate transcription.
C18432	HKR3_Gene	GLI_Family_Gene	HKR3 Gene|GLI-Kruppel Family Member HKR3 Gene|HKR3	The 9.5 kb human HKR3 Gene (Kr family) at 1p36.3 encodes HKR3 Protein, a 77 kD DNA-binding protein with eleven C2H2 zinc fingers separated by H/C links, an N-terminal tramtrack-associated box (BTB/POZ domain), and an acidic activation domain.  About 40 kb from D1S214, HKR3 contains a 5-prime CpG island and eleven exons.  Widely expressed 2.3 and 1.4 kb splice variants are observed; the smaller lacks TAB and activation domains.  HKR3 appears to bind to, and regulate, J or S elements in the MHC II promoter.  (from SWISS-PROT, OMIM, and NCI)
C18433	HCK_Gene	Non-Receptor_Tyrosine_Kinase_Gene	HCK Gene|HCK|Hemopoietic Cell Kinase Gene|JTK9	Human HCK Gene (SRC family) at 20q11-q12 appears to encode p59/60HCK, a membrane-associated tyrosine kinase that contains an SH2 and SH3 domain. HCK is expressed primarily in hematopoietic cells, especially of myeloid lineage and particularly in mature granulocytes and monocytes.  Two isoforms, p60HCK and p59HCK, are produced by alternative initiation.  HCK may couple the Fc receptor to activation of the respiratory burst.  It may also contribute to neutrophil migration and may regulate neutrophil degranulation.  HCK deletions may contribute to AML and myeloproliferative disorders.  (from SWISS-PROT, OMIM, and NCI)
C18434	Topoisomerase-II	Topoisomerase	Topoisomerase II|DNA Topoisomerase II|Topo II	Topoisomerase II catalyzes relaxation of supercoiled DNA molecules, catenation, decatenation, knotting, and unknotting of circular DNA.  The topoisomerase II reaction appears to involve crossing-over of two DNA segments.  Human cells contain two topoisomerase II isozymes: alpha and beta from distinct genes.  DNA topoisomerase II alpha is associated with the Pol II holoenzyme and is required for chromatin-dependent co-activation.  Transcription results in superhelical tension; topoisomerase II relaxation activity is essential for productive RNA synthesis on nucleosomal DNA.  (from OMIM 126430 and NCI)
C18435	Soluble_ERBB-2_Protein	ERBB2_Protein	Soluble ErbB-2|ERBB2|Herstatin|sErbB-2	Herstatin is a secreted alternative ERBB2 product, of the extracellular domain, that binds to p185ERBB2, disrupts ERBB2 dimers, reduces p185 phosphorylation, and inhibits growth.
C18436	Soluble_ERBB-1_Protein	ErbB_Receptor_Family_Protein	Soluble ErbB-1|EGFR|sErbB-1	A secreted form of erbB1 that may have utility as a tumor marker.
C18437	G_Protein_Gene	Signaling_Pathway_Gene	G Protein Gene|Proto-Oncogene, G-Protein	Classification.  Proto-oncogenes that code for G proteins.
C18438	Proto-Oncogene_Growth_Factor	Retired_Concepts	Proto-Oncogene, Growth Factor	Classification.  Proto-oncogenes that code for growth factors.
C18439	Proto-Oncogene_Nuclear_Protein	Retired_Concepts	Proto-Oncogene, Nuclear Protein	Classification.  Proto-oncogenes that code for products that are localized in the nucleus.
C18440	Proto-Oncogene_Transcription_Factor	Retired_Concepts	Proto-Oncogene, Transcription Factor	Classification.  Proto-oncogenes that code for transcription factors.
C18441	Proto-Oncogene_Protein-Kinase	Retired_Concepts	Proto-Oncogene, Protein-Kinase	Classification.  Proto-oncogenes that code for protein kinases.
C18442	Proto-Oncogene_Tyrosine-Kinase	Retired_Concepts	Proto-Oncogene, Tyrosine-Kinase	Classification.  Proto-oncogenes that code for products with protein tyrosine kinase activity.
C18443	Oncogene_LMYC	LMYC_Gene	Oncogene LMYC|MYC Related Gene From Lung Cancer	Human Oncogene LMYC is a mutated variant of LMYC Gene (MYC Family), which encodes L-MYC Protein, a bZIP transcription factor that binds to DNA as a heterodimer with MAX; DNA binding requires dimerization with another bHLH protein. The gene is amplified 10- to 20-fold in small-cell lung cancer (SCCL). Several LMYC mRNAs are produced in SCCL cells by alternative splicing and alternative polyadenylation. Oncogene LMYC disrupts normal cell function.
C18444	Oncogene_NMYC	NMYC_Gene	Oncogene MYCN|N-MYC|Neuroblastoma MYC Oncogene|Oncogene NMYC|v-MYC Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived (Avian)	Human Oncogene NMYC is a mutated variant of NMYC Gene (MYC Family), which encodes two nuclear N-MYC Proteins from the same mRNA; both are phosphorylated, exceptionally unstable and bind to single- and double-stranded DNA. N-MYC is a likely heterodimeric bZIP transcription factor with MAX; efficient DNA binding requires dimerization with another bHLH protein. NMYC amplification is associated with oncogenic transformation. Oncogene NMYC disrupts normal cell function.
C18445	MAS1_Gene	G_Protein-Coupled_Receptor_Gene	MAS1 Gene|MAS|MAS1|MAS1 Oncogene Gene	Oncogene MAS encodes a novel G protein coupled receptor that was originally identified as a transforming protein when over expressed in NIH 3T3 cells. MAS has greatest sequence similarity to the substance K receptor and may encode a peptide receptor with mitogenic activity that acts through inositol lipid signaling pathways. MAS may be a receptor in a growth-regulating pathway; it seems to be involved in some aspect of angiotensin signaling. The human gene is located at 6q24-q27.
C18446	ELK3_Gene	ETS_Family_Gene	ELK3 Gene|ELK3|ELK3, ETS-Domain Protein (SRF Accessory Protein 2) Gene|ERP|NET|SAP2|SAP2 Gene	Human ELK3 Gene (ETS Family) at 12q23 encodes ELK3 Protein, a DNA-binding transcription factor highly expressed at early stages of B-lymphocyte development.  Expression of the 2.5 and 4.5 kb mRNAs declines upon B-cell maturation and correlates with Ig heavy chain enhancer activity.  ELK3 may play a role in B-cell development and immunoglobulin gene regulation.  ELK3 may be a negative transcription regulator, but can activate transcription when co-expressed with RAS, SRC or MOS.  ELK3 interacts with CTBP1 and can form ternary complexes with serum response factor on the ETS and SRF motifs of the FOS gene serum response element.  (from SWISS-PROT, OMIM, and NCI)
C18447	ST5_Gene	Signaling_Pathway_Gene	ST5 Gene|HTS1|P126|P70|P82|ST5|Suppression of Tumorigenicity 5 Gene	The human ST5 gene is expressed as 4.6, 3.1 and 2.8 kb transcripts encoding putative 126, 82 and 70 kDa proteins that function in the MAP kinase signaling pathway in transient expression assays.
C18448	SPINK1_Gene	Proteinase_Inhibitor_Gene	SPINK1 Gene|PSTI|PSTI Gene|SPINK1|Serine Protease Inhibitor, Kazal Type 1 Gene	SPINK1 encodes serine protease inhibitor, Kazal type 1. The gene product is secreted from pancreatic acinar cells into pancreatic juice and is thought to prevent trypsin-catalyzed premature activation of pancreatic zymogens.  It is also found in serum and various normal tissues; SPINK1 is produced by gastrointestinal tract mucosa where it may protect mucosal cells from proteolytic breakdown.  (from OMIM 167790 and NCI)
C18449	Oncogene_SKI	Oncogene_Transcription_Factor	Oncogene SKI|SKI|SKV|V-SKI Avian Sarcoma Viral Oncogene Homolog|V-SKI Sarcoma Viral Oncogene Homolog (Avian)	The SKI oncogene was originally isolated from Sloan-Kettering viruses (SKVs), a group of replication-defective transforming retroviruses.  The c-SKI proto-oncogene encodes a transcriptional repressor that homo- and heterodimerizes with the related protein, snoN.  SMAD3 associates with nuclear SKI protein in response to TGFB1 signaling, repressing transcriptional activation by SMAD3, and rendering cells resistant to the growth-inhibitory effects of TGFB.  The effects of SKI can be overcome by increased expression of SMAD3.  The human gene is located at 1q22-q24.
C18450	Oncogene_ETS	ETS1_Gene	Oncogene ETS|E26 Transformation Specific Oncogene|ETS	Oncogene ETS was originally discovered as a chimeric component, along with a truncated v-myb gene, in the genome of E26, an avian leukosis virus. ETS1 encodes 42-52 kD nuclear phosphoprotein transcription factors that interact with purine-rich promoter/enhancer sequences in the TCRA gene. ETS1 also regulates p16(INK4A) gene expression. The human gene is located at 11q23.3.
C18451	ABL2_Gene	Non-Receptor_Tyrosine_Kinase_Gene	ABL2 Gene|ABL2|ABLL|ARG|Abelson Murine Leukemia Viral Oncogene Homolog 2|Abelson Related Gene|V-Abl Abelson Murine Leukemia Viral Oncogene Homolog 2 (Arg, Abelson-Related Gene) Gene	Human ABL2 Gene (ABL family) at 1q24-q25 produces a 12 kb transcript that encodes a widely expressed cytoplasmic tyrosine kinase with SH2 and SH3 domains.  Isoforms IA and IB are produced by alternative splicing.  ABL2 is fused with ETV6 in AML translocation t(1;12)(q25;p13) and is also involved in CML.  (from SWISS-PROT, OMIM, and NCI)
C18452	GLI3_Gene	GLI_Family_Gene	GLI3 Gene|GCPS|GLI-Kruppel Family Member 3|GLI-Kruppel Family Member GLI3 (Greig Cephalopolysyndactyly Syndrome) Gene|GLI3|PAP-A|PAPA|PHS	The 200-250 kb human GLI3 Gene (GLI/Kr family) at 7p13 encodes GLI3 Protein, a DNA-binding C2H2 zinc finger transcription factor likely required in limb and brain development.  Containing a 5-prime CpG island, two intragenic dinucleotide repeats, and fourteen exons, the gene expresses an 8.5 kb mRNA in lung, colon, spleen, placenta, testis, and myometrium.  Transactivating domains reside in the C-terminus, a DNA-binding domain lies in the central region.  GLI3 functionally mirrors its homologue, Ci (Drosophila).  In response to hedgehog, activator Ci is cleaved to a repressor.  GLI3 regulates PTCH and mediates SHH signal transduction.  In vertebrate limb development, PKA-dependent processing of GLI3 generates a repressor, antagonized by sonic hedgehog signaling.  GLI3 mutations may be responsible for Pallister-Hall Syndrome, Greig Cephalopolysyndactyly Syndrome, and Postaxial Polydactyly.  (from SWISS-PROT, OMIM, and NCI)
C18453	Oncogene_FPS-FES	FES_Gene	Oncogene FPS-FES|FES|FPS|Fujinami Sarcoma Virus and Feline Sarcoma Virus Transforming Gene|Oncogene FES	Human Oncogene FPS-FES is a mutated variant of FES Gene (FES/FPS Subfamily), which encodes 822 aa 93-kDa Tyrosine-Protein Kinase FES/FPS, a tyrosine-specific protein kinase involved in normal hematopoiesis and containing an FCH and SH2 domain. The FES chromosomal location is linked to a translocation identified in patients with acute promyelocytic leukemia. A truncated transcript is generated utilizing a start site in a far downstream exon. Oncogene FPS-FES disrupts normal cell function.
C18454	EMP1_Gene	Transmembrane_Protein_Gene	EMP1 Gene|B4B|CL-20|CL-20 Gene|EMP1|Epithelial Membrane Protein-1 Gene|TMP|Tumor-Associated Membrane Protein-1 Gene	Human EMP1 Gene (PMP-22/EMP/MP20 Family) at 12p12.3 contains five exons that encode Epithelial Membrane Protein-1, an integral membrane protein containing four transmembrane domains likely involved in cell-cell interactions and control of cell proliferation.  EMP1 expression is seen in embryonic kidney, brain, and gut, but not in liver and thymus.  A 2.8 kb EMP1 transcript is found in most adult tissues, but not in brain, liver, pancreas, or peripheral leukocytes.  EMP1 is highly expressed in brain tumor cells. (from SWISS-PROT, OMIM, and NCI)
C18455	BCR_Gene	Serine-Threonine_Protein_Kinase_Gene	BCR Gene|ALL|BCR|BCR1|Breakpoint Cluster Region Gene|CML|D22S11|D22S662|PHL	The BCR Gene at 22q11.21 encodes a cytoplasmic phosphoprotein with unique serine/threonine kinase activity and contains twenty-three exons with an unusual inverted repeat flanking the first exon. It is expressed as mRNAs of 4.5 and 6.7 kb, which encode the same 160 kD protein. The gene is oriented 5-prime centromeric. BCR is located at the breakpoints of Philadelphia chromosome translocations that join to the ABL gene found in CML, AML, and ALL. BCR Protein promotes the activating exchange of GTP for GDP bound by p21 or CDC42. The region of BCR involved in binding to the ABL SH2 domain is rich in serine residues and must be serine/threonine phosphorylated prior to SH2 binding. This region is essential for activation of ABL tyrosine kinase. BCR is autophosphorylated and contains a DBL, a PH, a C2, and a GAP domain. (from SWISS-PROT, OMIM, and NCI)
C18456	S-Phase_Fraction	Properties_or_Attributes	S-Phase Fraction|Cell Proliferative Activity|Cellular Proliferation Rate|Mitotic Index|PI|Proliferation Index|S-phase fraction|SPF	A measure of the percentage of cells in a tumor that are in the phase of the cell cycle during which DNA is synthesized. The S-phase fraction may be used with the proliferative index to give a more complete understanding of how fast a tumor is growing.
C18457	Oncogene_TRK	NTRK1_Gene	Oncogene TRK|Oncogene, NTRK1|Oncogene, Neurotrophic Tyrosine Kinase, Receptor, Type 1 Gene|Oncogene, TRKA	Human Oncogene TRK is a mutated variant of NTRK1 Gene (INSR family), which encodes two alternative type I membrane protein Neurotrophic Tyrosine Kinase Receptor Type 1 with similar biological properties. TRKA-II is primarily expressed in neurons; TRKA-I is non-neuronal. NTRK1 exists as low affinity monomeric and high affinity dimeric structures, with TRKA, TRKB, or TRKC, that bind neurotrophins. TRKA, TRKB, and TRKC partners are preferred by NGF, NTF5 and BDNF, and NTF3, respectively. Ligands stimulate autophosphorylation of TRK. NTRK1 defects cause CIPA. Oncogene TRK disrupts normal cell function.
C18458	THPO_Gene	Growth_Factor_Gene	THPO Gene|MGDF Gene|MPLLG Gene|THPO|TPO Gene|Thrombopoietin (Myeloproliferative Leukemia Virus Oncogene Ligand, Megakaryocyte Growth and Development Factor) Gene|Thrombopoietin Gene	The THPO oncogene encodes thrombopoietin, a lineage-restricted glycoprotein growth factor with stimulatory effects on megakaryopoiesis and platelet production.  The human gene is located at 3q26.3-q27.
C18459	KAI1_Gene	Cell_Adhesion_Molecule_Gene	CD82 Gene|4F9|C33|CD82|CD82 Antigen Gene|GR15|IA4|KAI1|KAI1 Gene|R2|SAR2|ST6	Expressed in many tissues, the 80 kb human KAI1 Gene (TM4SF family) at 11p11.2 contains ten exons that specify metastasis suppressor KAI1 Protein, with four putative transmembrane domains and a large extracellular domain having three potential N-glycosylation sites.  KAI1 appears to be up regulated in activated T-cells.  p53 activates the gene by interacting with sequences in a 5-prime upstream region.  Loss of p53 appears to cause down regulation of KAI1.  Similar to leukocyte cell surface glycoproteins involved in cell adhesion and signal transduction, KAI1 is a likely homologue of mouse leukocyte surface antigen R2, similar to CD37 and CD53.  Associated with CD4 or CD8, KAI1 delivers co-stimulatory signals for the TCR/CD3 pathway.  KAI1 expression at the transcription or posttranscription level is often down regulated during tumor progression. (from SWISS-PROT, OMIM, and NCI)
C18460	CXCL1_Gene	CXC_Cytokine_Gene	CXCL1 Gene|CXCL1|Chemokine (C-X-C Motif) Ligand 1 Gene|GRO|GRO1|GROA|MGSA|Melanoma Growth Stimulatory Activity, Alpha, Gene|NAP-3|SCYB1	Human GRO1 Gene (CXC family) at 4q12-q13 encodes mitogenic polypeptide Melanoma Growth Stimulating Activity.  Related to platelet derived beta-thromboglobulin and acting through a G protein coupled receptor, chemokine MGSA-alpha belongs to a family that includes pro-inflammatory IL8 and PF4.  Chemotactic for polymorphonuclear leukocytes, GRO1 may play a role in inflammation.  Macrophages secrete GRO1 in response to endotoxin. GRO1 also affects endothelial cells involved in angiogenesis or angiostasis in an autocrine fashion and affects the central nervous system as well.  (from SWISS-PROT, OMIM, and NCI)
C18461	ELK1_Gene	ETS_Family_Gene	ELK1 Gene|ELK-1|ELK1|ELK1, Member of ETS Oncogene Family Gene	Human ELK1 Gene (ETS Family) at Xp11.2 encodes ELK1 Protein, a putative DNA-binding transcription factor active in testis and lung.  Two isoforms are produced by alternative splicing.  ELK1 binds to purine-rich DNA; it can form a ternary complex with serum response factor on the ETS and SRF motifs of the FOS gene serum response element.  ELK1 is phosphorylated by three MAP kinase groups (p38, JNK, and ERK).  ELK2 is a processed pseudogene of ELK1.  (from SWISS-PROT, OMIM, and NCI)
C18462	Oncogene_HST	FGF4_Gene	Oncogene HST|FGF4|FGF4 Oncogene|Fibroblast Growth Factor 4 Oncogene|HSTF1|Human Stomach Cancer Derived Oncogene|K-FGF|Kaposi Sarcoma Oncogene	Human Oncogene HST is a mutated variant of FGF4 Gene (FGF Family) about 35 kb downstream of INT2 (same orientation), which encodes Fibroblast Growth Factor 4, a heparin-binding growth factor with homology to basic and acidic FGF. Gremlin relays an SHH signal from the polarizing region to the apical ectodermal ridge. Formin-dependent activation of BMP-antagonist Gremlin induces FGF4 and the SHH/FGF4 feedback loop. Oncogene HST disrupts normal cell function.
C18463	NKTR_Gene	Receptor_Gene	NKTR Gene|NKTR|Natural Killer Triggering Receptor Gene|Natural Killer-Tumor Recognition Sequence	Human NKTR Gene at 3p23-p21 encodes Natural Killer Triggering Receptor, involved in the recognition of tumor cells by the LGL subpopulation of granular lymphocytes that kill tumor cells by an MHC-independent mechanism.  Attached to the surface of LGLs via its hydrophobic N-terminus followed by a cyclophilin-like PPIASE domain, the 150 kD gene product facilitates binding to tumor targets.  Alternative splicing occurs in the 5-prime region.  Use of an alternate exon 6 produces a truncated protein, while use of an alternate splice acceptor in exon 9 generates a deletion.  LGL activation by IL2 changes the splicing pattern to enhance production of a full-length protein. (from SWISS-PROT, OMIM, and NCI)
C18464	Oncogene_RET	RET_Gene	Oncogene RET|HSCR1|MEN2A|MEN2B|MTC1|PTC Oncogene|RET	Human Oncogene RET is a mutated variant of RET Gene, which encodes Tyrosine-Protein Kinase Receptor RET, a type I membrane protein receptor for Glial Cell Line-Derived Neurotrophic Factor with an extracellular cadherin-like domain and important in neural crest development. Some oncogenic RET point mutations cause constitutive kinase activation.  PTC1 oncogene involves fusion of RET kinase to the H4 dimerization leucine zipper.  In PTC6, RET is fused to the N-terminal part of Transcriptional Intermediary Factor-1-alpha. In PTC7, RET is fused to a C-terminal part of TIF1-gamma. Oncogenic RET mutations are associated with Hirschsprung's disease, Multiple Endocrine Neoplasia, pheochromocytoma, hyperparathyroidism and medullary thyroid cancer. Oncogene RET disrupts normal cell function.
C18465	Research_Ethics	Ethics	Research Ethics	The branch of ethics that studies moral values in research sciences and practices.
C18466	Regulatory_Protein	Protein_Organized_by_Function	Regulatory Protein	Encoded by Regulatory Genes, Regulatory Proteins regulate or circumscribe the activity of many cellular functions.
C18467	Digital_Mammography	Mammography	Digital Mammography	Digital mammography assists in the early detection of breast cancer by incorporating modern electronics and computers into x-ray mammography methods. Instead of acquiring an image on film, it is collected electronically and can be stored directly into a computer.  Digital mammography is quick and has the potential to reduce patient anxiety and inconvenience. Moreover, digital mammograms are easily archived and electronically transferable, making them ideal for teaching purposes and for evaluation during long-distance telemedicine consultations.
C18468	Virtual_Reality	Computer_System	Virtual Reality	An artificial environment generated by a computer that simulates the actual (real) world.  Users can control VR programs through sensory loaded gloves and headsets, that are equipped with video monitors that give feeling of movement through 3-dimensional "virtual" environments.
C18469	Protein-Protein_Interaction	Molecular_Interaction	Protein-Protein Interaction	Temporary, non-covalent binding between protein molecules. Protein-protein interactions occur as a result of intermolecular physical forces and spatial complementation between domains or motifs. This interaction can be either homotypic or heterotypic and effect protein structure, conformation, and function.
C18470	Computational_Chemistry	Chemistry	Computational Chemistry	Computational chemistry is the branch of theoretical chemistry whose major goals are to create efficient computer programs that calculate the properties of molecules (such as total energy, dipole moment, vibrational frequencies) and to apply these programs to concrete chemical objects. (from Information Headquarters)
C18471	Genetic_Epidemiology	Epidemiology	Genetic Epidemiology|Epidemiology, Genetic	Interdisciplinary clinical, epidemiologic, genetic, and laboratory studies of persons, families, and populations at high risk of cancer. These investigations identify genes and exposures conferring cancer predisposition, and explore the combined effects of predisposition and specific exposures. (from DCEG homepage)
C18472	High_Throughput_Screening	Techniques	High Throughput Screening|High Throughput Assay	Use of robots and other automated techniques to screen large numbers of samples.
C18473	RNA_Analysis	Molecular_Biology_Techniques	RNA Analysis	Molecular biology techniques, including Northern Blot, Differential display, RT-PCR, and RNase protection for qualifying or quantifying RNA. (NCI/OSP)
C18474	Yeast_Protein	Non-Human_Protein	Yeast Protein	Proteins found in any species of yeast.
C18475	Liquid_Chromatography_Mass_Spectrometry	Liquid_Chromatography|Mass_Spectrometry	Liquid Chromatography Mass Spectrometry|LC/MS|Liquid Chromatography-Mass Spectrometry	LC/MS is a hyphenated technique, combining the separation power of liquid chromatography (LC), an analytical chromatographic technique for separating ions or molecules dissolved in a solvent, with the detection power of mass spectrometry(MS), a technique to separate gas phase ions according their m/z (mass to charge ratio) value. Used for drug screening, pharmacology studies, environmental analyses and forensics. (NCI2005)
C18476	Underserved_Population	Population_Group	Underserved Population|Medically Underserved Populations|Underserved Populations	Populations that do not have adequate access to medical care. This includes rural, elderly, low-literacy, blue collar, and poor populations. Minorities per se are not included but often belong to one or more or the included categories.
C18477	Microarray_Analysis	Molecular_Biology_Techniques	Microarray Analysis|Microarray Technology|Microarray-Based Analysis	Analysis using microarray technology (e.g., cDNA arrays to see gene expression or protein microarrays to profile the pattern of proteins).
C18478	Nanotechnology	Technology	Nanotechnology|Nanoscale Science|Nanotech	Nanotechnology is the branch of engineering that deals with things smaller than 100 nanometers (especially with the manipulation of individual molecules).  The term is often used to refer to technological developments on the nanometer scale. (from Wikipedia)
C18479	Neuropathology	Pathology	Neuropathology	morphological and other aspects of diseases of the nervous system.
C18480	Serial_Analysis_of_Gene_Expression	Molecular_Biology_Techniques	Serial Analysis of Gene Expression|SAGE	Serial analysis of gene expression (SAGE) is novel method of assessing the variation in the type or amount of genes expressed in different tissues, at different times in development or in normal versus malignant cells.
C18481	MSH2_Gene	DNA_Repair_Gene	MSH2 Gene|COCA1|FCC1|HNPCC|HNPCC1|MSH2|MutS Homolog 2, Colon Cancer, Nonpolyposis Type 1 (E. coli) Gene	The MSH2 gene (MUTS family) at 2p22-p21 encodes DNA Mismatch Repair Protein MSH2, a postreplication mismatch repair homologue of mutS (E. coli), which binds to insertion-deletion looped DNA mismatches. MutS homologues have ATPase activity and contain a conserved DNA binding helix-turn-helix domain associated with an adenine nucleotide/magnesium-binding Walker-A motif that may regulate mismatch binding as a molecular switch. ADP-bound MSH2/MSH6 binds to mismatched DNA, provoking ADP/ATP exchange and MSH2/MSH6 migration along the DNA backbone. DNA-bound, ATP-bound MSH2/MSH6 activates the repair machinery. MSH2 is part of the multisubunit BASC complex, which may sense abnormal DNA structures and regulate postreplication repair. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. MSH2 alteration is associated with DNA instability. (From SWISS-PROT, OMIM, and NCI)
C18482	MLH1_Gene	DNA_Repair_Gene	MLH1 Gene|COCA2|FCC2|HNPCC|HNPCC2|MGC5172|MLH1|MutL Homolog 1, Colon Cancer, nonpolyposis type 2 (E. coli) Gene|hMLH1	The MLH1 gene (MUTL/HEXB family) at chromosome 3p21.3 is a mismatch repair gene that consists of nineteen coding exons with exons 1 to 7 contain a highly conserved region. Widely expressed, several alternative splice variants occur in diverse tissue types. Some variants lack exons 6/9, 9, 9/10, 9/10/11, 10/11, 12, 16, or 17. The encoded protein, MutL Homolog 1 (MLH1), is part of the multi-subunit BASC complex, which may sense abnormal DNA structures and regulate post-replication repair. Heterodimeric MLH1 Protein and PMS2 provide repair proficiency on heteroduplex DNAs, as well as insertion/deletion mispairs. MLH1 and MLH3 also heterodimerize. Associated with colon, endometrial, and stomach cancers, the defects in MLH1 are a cause of hereditary non-polyposis colorectal cancer. (NCI)
C18483	Differential_Display	RNA_Analysis	Differential Display|Differential Display of mRNA	Variation of the polymerase chain reaction used to identify differentially expressed genes.  mRNA from two different tissue samples is reverse transcribed, then amplified using short, intentionally nonspecific primers.  The array of bands obtained from a series of such amplifications is run on a high resolution gel, and the array of bands compared with analogous arrays from different samples.  Any bands unique to single samples are considered to be differentially expressed; they can be purified from the gel, and sequenced and used to clone the full-length cDNA.  Similar in result to subtractive hybridization. (DCB-CB)
C18484	Nuclear_Hormone_Receptor_Superfamily	Nuclear_Receptor|Transcription_Factor	Nuclear Hormone Receptor Superfamily|Nuclear Hormone Receptor|Nuclear Hormone Receptors	Nuclear hormone receptors constitute a superfamily of structurally related ligand binding transcription factors that includes the steroid receptors, thyroid hormone receptors, vitamin D and retinoid receptors, and orphan receptors for which ligands have not yet been found.
C18485	Three_Dimensional_Imaging	Imaging_Technique	Three Dimensional Imaging|3-D Imaging|Medical Imaging, Three Dimensional	Technique to produce 3D images to provide the ability to visualize important structures in great detail. Traditionally CT and MRI scans produced static output on film. To produce 3D images, many scans are made, and then combined by computers to produce a 3D model, which can then be manipulated by the physician. 3D ultrasounds are produced using a somewhat similar technique.(NCI2005)
C18486	Horizontal_Gene_Transfer	Population_Process	Horizontal Gene Transfer	Gene transfer between species. (NCI)
C18487	Tumor_Necrosis_Factor_Beta_Receptor	TNF_Receptor_Family_Protein	Tumor Necrosis Factor Receptor Superfamily, Member 1B|Tumor Necrosis Factor Beta Receptor|Tumor Necrosis Factor Binding Protein 2|Tumor Necrosis Factor Receptor 2	A 70-kDa high-affinity cell surface receptor for tumor necrosis factor.
C18488	TEK_Tyrosine_Kinase	Receptor_Tyrosine_Kinase	TEK Tyrosine Kinase|Angiopoietin 1 Receptor|CD202B Antigen|Endothelial TEK Tyrosine Kinase|Epithelial-Specific Protein Receptor Tyrosine Kinase TIE-2|TEK Tyrosine Kinase, Endothelial|Tunica Interna Endothelial Cell Kinase|Tyrosine-Protein Kinase Receptor TEK|Tyrosine-Protein Kinase Receptor TIE-2|p140 TEK	Encoded by human TEK Gene (TIE Family) and expressed predominantly in endothelia and angioblasts, TEK Tyrosine Kinase receptor is a type I transmembrane protein closely related to the TIE receptor. With a unique extracellular domain containing 2 Ig-like C2 domains separated by 3 EGF-like domains connected to 3 FN III-like domains, the ANG1 and ANG2 receptor TEK is important in angiogenesis, endothelial cell proliferation and differentiation, and endothelial cell patterning during vascular morphogenesis. TEK may constitute a mammalian endothelial cell lineage marker. Activating defects and deficiencies in TEK are associated with venous malformations (VMCM). (from LocusLink, Swiss-Prot, OMIM, and NCI)
C18489	CD209_Antigen	Cell_Adhesion_Molecule	CD209 Antigen|CD209|CDSIGN|DC-SIGN|DC-SIGN1|Dendritic Cell Specific Intercellular Cell Adhesion Molecule Grabbing Non-Integrin|Dendritic Cell-Specific ICAM3-Grabbing Nonintegrin|HIV gp120-Binding Protein	A dendritic cell-specific receptor for ICAM-3.  It can bind to HIV gp120, thereby transporting it to internal sites and facilitating trans infection of secondary lymphoid organs rich in T cells.
C18490	ERBB3_Receptor_Protein-Tyrosine_Kinase	ErbB_Receptor_Family_Protein	ERBB3 Receptor Protein-Tyrosine Kinase|ERBB3 Protein|Tyrosine Kinase-Type Cell Surface Receptor HER3|c-erbB-3	HER3/erbB3.  Member of the EGF receptor (erbB) family.  Receptor for NDF/heregulin (Neu differentiation factor); heterodimerizes with other type I receptor tyrosine kinases. It is overexpressed frequently in several common solid tumors, including in breast cancer.
C18491	Cell_Cycle_Kinetics	Molecular_and_Cellular_Biology	Cell Cycle Kinetics|Cell Kinetics	Cell cycle kinetics is the rate at which a cell progresses through the cell cycle.  It is a general indication of how fast a tissue or cell sample is proliferating.  This rate is generally increased in more aggressive tumors and can be measured by various biochemical methods such as the incorporation of labeled nucleotides into replicating DNA or the level of expression of cell cycle proteins or other proliferation markers.
C18492	Cyclin-Dependent_Kinase_Inhibitor	Cell_Cycle_Protein	Cyclin-Dependent Kinase Inhibitor|CDK Inhibitor Protein|CDKI Protein|Cyclin Kinase Inhibitor|Cyclin-Dependent Kinase Inhibitors	Encoded by Cyclin-Dependent Kinase Inhibitor Genes, Cyclin-Dependent Kinase Inhibitor Proteins are a group of low molecular weight proteins that associate with Cyclin/CDK complexes or CDKs alone, inhibiting their activity and regulating the cell cycle. (From OMIM and NCI)
C18493	Risk_Marker	Biomarker	Risk Marker|Markers, Risk	A characteristic that indicates the risk of developing a disease.
C18494	Oncogene_EGF	EGF_Gene	Oncogene EGF|URG	Human Oncogene EGF is a mutated variant of EGF Gene, which encodes Epidermal Growth Factor, a 53-aa peptide hormone with profound effects on cell differentiation and potent mitogenic effects on a variety of ectodermal and mesodermal cells. The EGF precursor is believed to exist as a membrane-bound molecule that is proteolytically cleaved to generate the hormone. Oncogene EGF disrupts normal cell function.
C18495	Unclassified_Oncogene	Oncogene	Oncogenes, Other	Any oncogene (cancer-causing gene) that is derived from a proto-oncogene (normal gene) which has an unknown or unclassified cellular function. Genetic mutations that convert a proto-oncogene to an oncogene can be inherited or occur somatically.
C18496	Protein_Phosphorylation	Post-Translational_Modification	Protein Phosphorylation|Phosphorylation	Protein phosphorylation is one of various post-translational protein modifications that regulates protein function and enzymatic activity.  The major phosphoryl acceptors in proteins are serine, threonine, and tyrosine.
C18497	Tyrosine_Phosphorylation	Protein_Phosphorylation	Tyrosine Phosphorylation	Tyrosine phosphorylation involves the introduction of a phosphoryl group into a compound through the formation of an ester bond between a tyrosine residue in the compound and a phosphorus moiety.
C18498	CYP1A1_Gene	Cytochrome_P450_Family_Gene	CYP1A1 Gene|AHH|AHRR|CP11|CY11|CYP1|CYP1A1|Cytochrome P450, Family 1, Subfamily A, Polypeptide 1 Gene|P1-450|P450-C|P450DX|P450D\X	Human CYP1A1 gene (cytochrome P450 family 1, subfamily A), located at 15q22-q24, encodes cytochrome P450 1A1, a monooxygenase enzyme that metabolizes polyaromatic hydrocarbons (PAHs). Individuals with a high-inducibility phenotype, who exhibit elevated CYP1A1 gene expression in response to PAHs, may be at greater risk for cigarette smoke-induced bronchogenic carcinoma.
C18499	CYP2E1_Gene	Cytochrome_P450_Family_Gene	CYP2E1 Gene|CPE1|CYP2E|CYP2E1|Cytochrome P450, Family 2, Subfamily E, Polypeptide 1 Gene|P450-J|P450C2E	Human CYP2E1 gene (cytochrome P450 family 2, subfamily E), located at 10q24.3-10qter, encodes the cytochrome P4502E1 protein. One allele of this gene contributes to the poor metabolizer phenotype, which is characterized by the inability to use cytochrome P450-dependent metabolic pathways for drug elimination. Polymorphisms of the CYP2E1 gene are associated with increased risk of esophageal cancer.
C18500	MTHFR_Gene	Oxidoreductase_Gene	MTHFR Gene|5,10-Methylenetetrahydrofolate Reductase (NADPH) Gene|MTHFR	A colon cancer modifier, Human MTHFR Gene (MTHFR family) at 1p36 is composed of eleven exons that encode methylene tetrahydrofolate reductase.  Exon sizes, location of intron boundaries, and intron sizes are similar between the human and mouse genes; amino acid sequences share nearly 90% identity.  Involved in folate metabolism, the homodimeric enzyme catalyzes, with cofactor FAD, the conversion of 5,10-methylene tetrahydrofolate to N(5)-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine.  MTHFR enzyme is allosterically regulated by S-adenosylmethionine.  Defects in MTHFR cause homocysteinemia. (NCI)
C18501	NQO1_Gene	Oxidoreductase_Gene	NQO1 Gene|DHQU|DIA4|DTD|NAD(P)H Dehydrogenase, Quinone 1 Gene|NMOR1|NMORI|NQO1|QR1	A lung cancer modifier and member of the NADPH Quinone Oxido-Reductase (NQO) family, the 10 kb human NQO1 Gene at 16q22.2 has four potential polyadenylation sites and encodes cytoplasmic Quinone Oxidoreductase, a two-electron homodimeric reductase that, with cofactor FAD, detoxifies quinones derived from the oxidation of phenolic metabolites of benzene.  Three transcripts appear to be differentially regulated.  Synthetic antioxidants and cruciferous vegetables are potent gene inducers.  Quinone oxidoreductase accepts electrons with equal efficiency from NADH and NADPH.  NQO1 also participates in the vitamin K-dependent gamma-carboxylation of glutamatyl residues in prothrombin synthesis.  Reduced NQO1 activity may promote vulnerability to leukemia secondary to chemical exposure.  (from SWISS-PROT, OMIM, and NCI)
C18502	SRD5A2_Gene	Oxidoreductase_Gene	SRD5A2 Gene|SRD5A2|Steroid-5-Alpha-Reductase, Alpha Polypeptide 2 (3-oxo-5 Alpha-Steroid Delta 4-Dehydrogenase Alpha 2) Gene	The SRD5A2 gene is a human prostate cancer modifier gene that encodes a steroid 5-alpha-reductase enzyme.  The human gene is located at 2p23.
C18503	VDR_Gene	Receptor_Gene	VDR Gene|NR1I1|VDR|Vitamin D (1,25- Dihydroxyvitamin D3) Receptor Gene	The VDR gene is a human prostate cancer modifier gene that encodes a vitamin D receptor.  Vitamin D3 receptors are intracellular polypeptides of 50-60 kD that specifically bind 1, 25(OH)2D3 and interact with target-cell nuclei to produce a variety of biologic effects.  VDR belongs to the superfamily of trans-acting transcriptional regulatory factors, including the steroid and thyroid hormone receptors.  VDR is more closely related to the thyroid hormone receptors than to the others.  The human gene is located at 12q12-12q14.
C18504	MADH3_Gene	Signaling_Pathway_Gene	SMAD3 Gene|JV15-2|MADH3|SMAD, Mothers Against DPP Homolog 3 (Drosophila) Gene|SMAD3	The SMAD3 gene is a human homologue of Drosophila Mad and is required for the TGF beta signal transduction pathway.  MADH3 activity is regulated by TGF beta receptors.  MADH3 is phosphorylated and associates with ligand-bound receptor complex, defining MADH3 as an effector of the TGF beta response.  MADH3 and MADH4 synergize.  SMAD3 and SMAD4 proteins specifically recognize an eight base pair palindromic sequence, which confers TGF beta responsiveness to a minimal promoter.  The human gene is located at 15q22.33.
C18505	Short_Tandem_Repeat_Polymorphism	Genetic_Polymorphism	Short Tandem Repeat Polymorphism|Polymorphism, Short Tandem Repeat|STRP|Simple Tandem Repeat Polymorphism	Short Tandem Repeat Polymorphism consists of variation between individuals in the number of repeat units of Simple Tandem Repeats at a specific location in the genome. These are used extensively as markers in gene mapping and linkage analysis.
C18506	ErbB_Receptor_Family_Protein	Growth_Factor_Receptor	ErbB Receptor Family Protein|erbB Receptor Family	A family of cellular proteins encoded by the c-erbB genes, including epidermal growth factor receptor. They are normally expressed in a variety of tissues of epithelial, mesenchymal, and neuronal origin.  They are overexpressed in a significant portion of adenocarcinomas found at various sites, especially in the breast. Gene amplification appears to be the predominant method leading to overexpression.
C18507	ERB_Oncogene_Family	Tyrosine-Kinase_Oncogene	ERB Oncogene Family	Retrovirus-associated DNA sequences originally isolated from, or related to, the avian erythroblastosis virus (AEV). The c-erbA proto-oncogene encodes the thyroid hormone receptors, and the c-erbB family codes for the epidermal growth factor receptor (erbB-1, EGFR) and related receptors (erbB-2, erbB-3).
C18508	REL_Protein	Transcription_Factor	REL Protein|REL	REL protein is a product of the REL proto-oncogene and may play a role in differentiation and lymphopoiesis.  It belongs to the REL/Dorsal family of transcription factors, containing the REL Homology Region (RHR), that includes NFKB and NF-AT.  Some members of this family are regulated by subcellular sequestration in the cytoplasm by members of the IKB protein subfamily of RHR proteins, and are involved in embryonic development and differentiation.  (from OMIM 164910 and NCI)
C18509	EPH_Tyrosine_Kinase-1	Ephrin_Receptor	EPH Tyrosine Kinase 1|EC 2.7.1.112|EPHA1|Ephrin Receptor EphA1|Ephrin Type-A Receptor 1|Erythropoietin-Producing Hepatoma Amplified Sequence|Receptor Tyrosine Kinase EPH|Tyrosine-Protein Kinase Receptor EPH	EPH tyrosine kinase 1 is a member of the largest subfamily of RTKs. EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. EPH-family receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and two fibronectin type III repeats. EPH receptors are divided into two groups based on their extracellular domain sequences and affinities for ephrin-A (EPHA) and ephrin-B ligands (EPHB).  Ephrin-A2 forms a stable complex with the metalloproteinase Kuzbanian, involving interactions outside the cleavage region and the protease domain.  EPH tyrosine kinase 1 receptor binding triggers ephrin-A2 cleavage in a localized reaction specific to the cognate ligand. (from OMIM 179610 and NCI)
C18510	NOV_Gene	Ligand_Binding_Protein_Gene	NOV Gene|IGFBP9|Insulin-Like Growth Factor Binding Protein-9 Gene|NOV|Nephroblastoma Overexpressed Gene	Expressed in hematopoietic cells, human NOV Gene (CCN family) at 8q24.1 appears to encode Insulin-Like Growth Factor-Binding Protein-9, a cysteine-rich growth regulation immediate-early protein expressed after growth factor induction.  Mouse, human, and chick NOV genes are highly conserved in sequence and organization; the conserved exon structure reflects a modular organization of the protein, as does the distribution of its forty cysteine residues.  CCN proteins control cell proliferation and share several motifs: an IGFBP motif, an oligomeric complex-forming domain, a binding domain for soluble and matrix molecules, and a CT dimerization domain.  NOV protein contains one VWFC domain and a C-terminal cystine knot-like domain.  (from SWISS-PROT, OMIM, and NCI)
C18511	NBL1_Gene	Transcription_Factor_Gene	NBL1 Gene|D1S1733E|DAN|MGC8972|N03|NB|NBL1|NO3	Cloned by homology to the mouse DAN gene. In mouse, the DAN gene possesses a tumor suppressive activity when it is overexpressed in v-src transformed cells. One human study excluded DAN as a tumor suppressor in neuroblastoma through loss of heterozygosity studies. (from OMIM)
C18512	BCL1_Oncogene	CCND1_Gene	BCL1 Oncogene|B-Cell Chronic Lymphocytic Leukemia Associated Oncogene|B-cell Leukemia 1|BCL	Human cyclin D1 (BCL1) proto-oncogene, located at 11q13, encodes G1/S-specific cyclin D1 (CCND1) protein. BCL1 gene expression is activated in human B-cell lymphomas by translocation, t(11;14)(q13;q32), with immunoglobulin gene regions. Enhanced expression of cyclin D1 protein has also been detected in parathyroid adenomas due to a translocation, t(11;11)(q13;p15), resulting in fusion of BCL1 with the parathyroid hormone enhancer.
C18513	Nuclear_Grade	Histopathologic_Grade	Nuclear Grade|nuclear grade	An evaluation of the size and shape of the nucleus in tumor cells and the percentage of tumor cells that are in the process of dividing or growing. Cancers with low nuclear grade grow and spread less quickly than cancers with high nuclear grade.
C18514	SERPINB5_Gene	Cell_Adhesion_Molecule_Gene	SERPINB5 Gene|Mammary Serpin Gene|Maspin Gene|PI5|SERPINB5|Serine (or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 5 Gene	Human Maspin Gene (Serpin family) at 18q21.3 encodes Maspin in a single 3 kb mRNA, which blocks growth, invasion, and metastasis of mammary tumors.  In the 300 kb telomere-centromere cluster of PAI2-SCCA1-SCCA2-PI5 serine proteinase inhibitor genes, SCCA1 and SCCA2 transcribe centromerically, opposite to PAI2 and PI5.  Maspin does not undergo serpin conformational transitions and exhibits no serine protease inhibitory activity, but plays a role in cell-matrix adhesion, tumor invasion, and metastasis.  High maspin expression appears to oppose lymph node metastasis.  Higher expression is associated with better survival rates and may be a favorable prognostic marker.  (from SWISS-PROT, OMIM, and NCI)
C18515	Signaling_Protein	Protein_Organized_by_Function	Signaling Protein	Proteins or peptides that participate in signal transduction processes in the cell.
C18516	CSF1R_Gene	Cytokine_Receptor_Gene	CSF1R Gene|CD115|CD115 Gene|CSF1R|CSFMR|Colony Stimulating Factor 1 Receptor Gene|Colony Stimulating Factor 1 Receptor, Formerly McDonough Feline Sarcoma Viral (v-fms) Oncogene Homolog Gene|FMS|c-FMS	Homologue of the v-fms McDonough feline sarcoma oncogene, proto-oncogene CSF1R encodes the macrophage colony-stimulating factor 1 receptor tyrosine kinase.  Myelomonocytic cytokine receptors for macrophage colony-stimulating factor are expressed at low to moderate levels on primitive hematopoietic stem cells, absent on common lymphoid progenitors, and up regulated after myeloid lineage induction by IL2.  CSF signaling can regulate cell fate decisions, and down regulation of cytokine receptors that drive myeloid cell development may be a critical step in lymphoid commitment.  The human gene is located at 5q33-q35.
C18517	TEL-AML1_Oncogene	Fusion_Gene	TEL-AML1 Oncogene|TEL/AML1 Chimeric Gene|TEL/AML1 Fusion Gene	The result of a t(12;21) translocation, TEL-AML1 Oncogene encodes a fusion protein containing the helix-loop-helix domain of TEL, a member of the ETS-like family of transcription factors, and the DNA-binding and transactivation domains of the transcription factor AML1. (NCI)
C18518	Single_Nucleotide_Polymorphisms_in_Coding_Sequences	Single_Nucleotide_Polymorphism	Single Nucleotide Polymorphism in Coding Sequence|Single Nucleotide Polymorphism in cDNA Sequence|Single Nucleotide Polymorphisms in Coding Sequences|Single Nucleotide Polymorphisms in cDNA Sequences|cSNP	Single Nucleotide Polymorphisms in Coding Sequences consist of a variation at an appreciable frequency between individuals of a single interbreeding population of a single nucleotide, due to base substitution, at an equivalent location within a protein-coding region of a gene that may or may not cause an amino acid change in the protein product and a detectable phenotypic effect.
C18519	GSTP1_Gene	Transferase_Gene	GSTP1 Gene|DFN7|FAEES3|Fatty Acid Ethyl Ester Synthase III Gene|GST3|GST3 Gene|GSTP1|GSTPP|Glutathione S-Transferase Pi Gene
C18520	Metabolic_Marker	Biomarker	Metabolic Marker	Specific metabolic changes that characterize an organism's state of health or disease, or response to a particular therapeutic intervention, and helps make diagnosis more accurate or enable physicians to make diagnosis before symptoms appear and to track disease progression.
C18521	Cancer-Predisposing_Gene	Susceptibility-Resistance_Gene	Cancer-Predisposing Gene|Cancer Susceptibility Gene|Susceptibility Gene	Mutated forms of genes which encode proteins that are essential for the control and maintenance of normal cellular processes. Inherited or somatic mutations in the wild-type form of these genes alters control of their expression, resulting in a change in control of the cell cycle. Individuals who harbor cancer-predisposing genes require fewer somatic mutations for transformation of a particular cell, thereby predisposing them to the development of cancer.
C18522	Microsatellite_Mutator_Phenotype	Phenotype	Microsatellite Mutator Phenotype
C18523	RRAD_Gene	G_Protein_Gene	RRAD Gene|RAD|RAD Gene|RAD1|Ras-Related Associated with Diabetes Gene	The RAD gene encodes a 29 kD member of the RAS-guanosine triphosphatase superfamily that is associated with insulin resistance in type II diabetes mellitus.  Selectively over expressed in type II diabetic muscle, the RAD gene is normally expressed primarily in skeletal and cardiac muscle.  The human gene is located at 16q22.
C18524	FHIT_Gene	Hydrolase_Gene	FHIT Gene|FHIT|FRA3B|Fragile Histidine Triad Gene	Chromosomal fragile sites may be hotspots for chromosome rearrangements.  Containing the FRA3B fragile site, the FHIT gene is a target of homologous recombination between LINE sequences that result in internal gene deletions, probably due to carcinogenic damage at FRA3B sites.  FHIT, a putative tumor suppressor gene and member of the histidine triad family, encodes AP3A hydrolase.  AP3A, and AP4A, may regulate DNA replication and signal stress responses.  The conserved histidine triad residues are required for enzymatic activity.  The human gene is located at 3p14.2.
C18525	ABCC1_Gene	Transport_Protein_Gene	ABCC1 Gene|ABC29|ABCC|ABCC1|ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 1 Gene|GS-X|MRP|MRP1	Expressed in lung, testis, and peripheral blood mononuclear cells, the 200 kb human MRP1 Gene (ABC family) at 16p13.1 - telomeric to MYH11 - contains thirty-one exons that encode a plasma membrane drug-efflux transporter associated with multidrug resistance.  A 7.8-8.2 kb mRNA is transcribed and several variant transcripts maintain the open reading frame.  MRP1 contains a high proportion of class 0 introns.  Conservation of intron/exon organization and sequence suggest that MRP-related transporters evolved by fusion from a shared common ancestor with CFTR and MDR1 encoding polytopic membrane proteins.  MRP1 also appears to regulate LTC4 transport, which promotes chemotaxis to CCL19 and dendritic cell migration to lymph nodes.  MRP1 is over expressed in a multidrug-resistant SCLC cell line.
C18526	Transcription_Coactivator	Transcription_Regulatory_Protein	Transcription Coactivator|Transcription Activator|Transcription Factor Coactivator|Transcriptional Activator|Transcriptional Activator/Coactivator|Transcriptional Coactivator	A transcription cofactor that activates transcription from a RNA polymerase II promoter but does not bind DNA itself.
C18527	Transcription_Repressor_Corepressor	Transcription_Regulatory_Protein	Transcription Repressor/Corepressor|Repressor|Transcription Corepressor|Transcription Repressor|Transcriptional Corepressor|Transcriptional Repressor|Transcriptional Repressor/Corepressor	Transcription Repressor/Corepressor Gene encodes Transcriptional Repressor/Corepressor, proteins that can regulate transcription by binding to the operator and causing repression. (from Glick: Glossary of Biochemistry and Molecular Biology)
C18528	ARHGEF5_Gene	Signaling_Pathway_Gene	ARHGEF5 Gene|ARHGEF5|GEF5|P60|Rho Guanine Nucleotide Exchange Factor (GEF) 5 Gene|TIM|TIM1	TIM encodes a 60 kD protein containing a Dbl-homology domain, which is shared by several signal transducing molecules implicated as regulators of small GTP-binding proteins. TIM is thought to be involved in control of cytoskeletal organization through regulation of small GTP-binding proteins.  (from OMIM 600888 and NCI)
C18529	GLI_Family_Gene	Transcription_Factor_Gene	GLI Family Gene	GLI Family Genes encode DNA-binding GLI Family Proteins containing zinc finger repeats and involved in pattern formation.
C18530	FOSL1_Protein	FOS_Family_Protein	FOSL1 Protein|FOS-Like Antigen 1 Protein|FOS-Related Antigen 1 Protein|FOSL1|FRA1 Protein	FOSL1 protein is a possible heterodimeric nuclear protein that lacks transactivation domains and belongs to the bZIP family.  Transcription of FOSL1 is induced in osteoclast differentiation by RANKL, in a FOS-dependent manner.  (from SWISS-PROT P15407, OMIM 136515, and NCI)
C18531	FOSL2_Protein	FOS_Family_Protein	FOSL2 Protein|FOS-Like Antigen 2 Protein|FOS-Related Antigen 2 Protein|FOSL2|FRA2 Protein	A possible nuclear hetero-dimeric protein that belongs to the bZIP family.  FOSL2 protein can dimerize with JUN family proteins to form the transcription factor AP-1 complex and is a possible regulator of cell proliferation, differentiation, and transformation.  (from SWISS-PROT P15408, OMIM 601575, and NCI)
C18532	FGF4_Gene	Fibroblast_Growth_Factor_Gene_Family	FGF4 Gene|FGF4|Fibroblast Growth Factor 4 (Heparin Secretory Transforming Protein 1, Kaposi Sarcoma Oncogene) Gene|Fibroblast Growth Factor 4 Gene|HST|HST-1|HSTF1|KFGF|KS3	Human fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene) (FGF4) gene, located at 11q13, encodes fibroblast growth factor 4 protein. This gene exhibits oncogenic transforming activity and is amplified in a number of types of human tumors.
C18533	ABL2_Tyrosine_Kinase	Protein_Tyrosine_Kinase	ABL2 Tyrosine Kinase|ABL2|ABL2 Tyrosine-Protein Kinase|ARG Tyrosine Kinase	ABL2 tyrosine kinase is related to ABL.  A case of acute myeloid leukemia M4 carrying the t(1;12)(q25;p13) translocation involves a fusion between ETV6 and ABL2, resulting in a chimeric protein consisting of the HLH oligomerization domain of ETV6 and the SH2, SH3, and protein tyrosine kinase domains of ABL2.  (from OMIM 164690 and NCI)
C18534	JUN_Family_Protein	DNA_Binding_Protein	JUN Family Protein|JUN Proteins	Encoded by JUN Family Genes, nuclear leucine zipper JUN Family Proteins (JUN, JUNB, and JUND) can homodimerize, or heterodimerize with nuclear leucine zipper FOS Family Proteins, to form the specific promoter/enhancer DNA-binding AP-1 transcription factor complex that regulates target gene transcription in cell proliferation, differentiation, and transformation. (NCI)
C18535	A-RAF_Protein_Kinase	Serine-Threonine_Protein_Kinase	A-RAF Protein Kinase|A-RAF Serine/Threonine-Protein Kinase|ARAF1|PKS|PKS2|RAFA1|v-raf Murine Sarcoma 3611 Viral Oncogene Homolog 1	Encoded by human ARAF1 Gene (MIL/RAF Family), cytoplasmic A-RAF [serine/threonine] Protein Kinase contains a DAG binding and a RBD domain, and is involved in transduction of mitogenic signals from cell membrane to nucleus. (NCI)
C18536	MYC-Family_Oncogene	Oncogene_Transcription_Factor	MYC-Family Oncogene	Variants of proto-oncogenes that are members of the MYC family of early response genes, which encode regulatory proteins that act as homo- or hetero-dimers. These aberrant genes are activated by mutations or amplification, resulting in overexpression of the protein products. This can cause uncontrolled cell proliferation.
C18537	MYC_Family_Gene	Transcription_Factor_Gene	MYC Family Gene|MYC Gene	MYC Family Genes encode MYC Family Proteins, class III bHLH leucine zipper transcription factors having cellular proliferative and apoptotic roles. Dimerization via leucine zippers of MYC proteins with bHLH/lz proteins, such as MAX, is required for efficient DNA binding. Leucine zippers are present in many gene regulatory proteins, including CREB proteins, Jun/AP1 transcription factors, and FOS-type proteins, as well as MYC proteins. The periodically repeated leucine side chains extending from one alpha helix interdigitate with leucine residues of another alpha helix, facilitating coiled-coil dimerization; like charge repulsion in this region perturbs homodimer formation; heterodimers are promoted by opposing charge attractions. c-MYC transcription factor binds to CAC(GA)TG DNA sites. MYC sequences have been highly conserved throughout evolution, from Drosophila to vertebrates. (NCI)
C18538	MYC_Family_Protein	Transcription_Factor	MYC Family Protein|MYC Protein	MYC family proteins exhibit sequence homology with the transcription factor MYC protooncogene.
C18539	RET_Protein	Receptor_Tyrosine_Kinase	Tyrosine-Protein Kinase Receptor RET|Cadherin Family Memebr 12|Glial Cell Line Derived Neurotrophic Factor Receptor Component|Hydroxyaryl-Protein Kinase|RET|RET Gene Product|RET Protein	Encoded by human RET Gene, Tyrosine-Protein Kinase Receptor RET is a type I membrane protein receptor for Glial Cell Line-Derived Neurotrophic Factor with an extracellular cadherin-like domain and important in neural crest development.  Activation of the RET kinase results in autophosphorylation of tyrosine residues critical for signaling. RET mutations are associated with Hirschsprung's disease and Multiple Endocrine Neoplasia, pheochromocytoma, hyperparathyroidism and medullary thyroid cancer.
C18540	SRC_Family_Oncogene	Tyrosine-Kinase_Oncogene	SRC Family Oncogene	Human SRC Family Oncogenes are mutated variants of Tyrosine Kinase Family Genes, which encode diverse SRC Family Tyrosine Kinases, closely related intracellular non-receptor protein-tyrosine kinases with amino acid sequence similarity to SRC and to Rous sarcoma virus oncogene protein PP60(V-SRC). SRC tyrosine kinases interact with diverse cell-surface receptors and participate in intracellular signal transduction pathways in a variety of hematopoietic cells. Oncogenic SRC kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes. SRC family oncogenes disrupt normal cell function.
C18541	LCK_Gene	SRC_Family_Gene	LCK Gene|LCK|Lymphocyte-Specific Protein Tyrosine Kinase Gene|Lymphocyte-Specific Tyrosine Protein Kinase Gene	Human lymphocyte-specific protein tyrosine kinase (LCK) gene, located at 1p35.1, encodes proto-oncogene tyrosine-protein kinase LCK protein. This gene is associated with acute lymphoblastic leukemia and severe combined immunodeficiency.
C18542	FGR_Gene	SRC_Family_Gene	FGR Gene|FGR|Gardner-Rasheed Feline Sarcoma Viral (V-FGR) Oncogene Homolog|SRC2|c-fgr Gene	Human Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog (FGR) gene, located at 1p36.2-p36.1, encodes proto-oncogene tyrosine-protein kinase FGR protein. Amplification of this gene is associated with the development of hormone-resistant prostate cancer.
C18543	YES1_Gene	SRC_Family_Gene	YES1 Gene|YES1|c-YES Gene|v-Yes-1 Yamaguchi Sarcoma Viral Oncogene Homolog 1 Gene	Human YES1 Gene (SRC Family) encodes 543-aa 61-kDa tyrosine kinase p61-YES, containing an SH2 and an SH3 domain. (NCI)
C18544	Tumor-Associated_Calcium_Signal_Transducer-2	Cell_Surface_Receptor	Tumor-Associated Calcium Signal Transducer 2|Cell Surface Glycoprotein TROP-2|EpCAM|Epithelial Cell Adhesion Molecule|GA733-1 Antigen|Gastrointestinal Tumor-Associated Antigen 1|M1S1 Protein|Pancreatic Carcinoma Marker Protein|TACSTD2|TROP-2	Expressed in placenta by human TACSTD2 Gene (GA733 Family), 323-aa 36-kDa (precursor) type I membrane protein Tumor-Associated Calcium Signal Transducer 2 contains 1 Thyroglobulin Type-I domain, acts as a cell surface receptor, and transduces an intracellular calcium signal. The N-terminus is blocked. (NCI)
C18545	MAF_Family_Gene	Transcription_Factor_Gene	MAF Family Gene|MAF Gene	MAF proteins have been reported to be able to bind with FOS proteins to form the AP-1 transcription factor (from Nature Cell Biol. 4: E131-E136, 2002 via OMIM)
C18546	MAF_Family_Protein	Transcription_Factor	MAF Family Protein|MAF Proteins	MAF proteins have been reported to be able to bind with FOS proteins to form the AP-1 transcription factor (from Nature Cell Biol. 4: E131-E136, 2002 via OMIM)
C18547	CBL_Protein	Signaling_Protein	CBL Protein|CBL|CBL Gene Product|CBL2 Gene Product	The cellular homologue of v-cbl, CBL protein is expressed in a range of hemopoietic lineages.  Malignancies are associated with translocations of the CBL gene.  Adaptor protein CBL2, containing a RING finger and multiple SH3 domains, encodes a protein similar to SLI1, a negative regulator of an EGF receptor tyrosine kinase homologue.  Through its SH2 domain, CBL regulates activated tyrosine-phosphorylated receptor PTK ubiquitination as an E3 ubiquitin ligase and recruits, and activates, an E2 ubiquitin-conjugating enzyme through its RING domain.  CBL is recruited to the tyrosine kinase insulin receptor by CAP adaptor protein, through a CAP SH3 domain.  Upon CBL phosphorylation, CAP/CBL dissociates from the receptor to complex with caveolar flotillin and localize to plasma membrane lipid rafts.  (from OMIM 165360 and NCI)
C18548	NTRK1_Tropomyosin_Chimeric_Protein	Oncoprotein	NTRK1/Tropomyosin Chimeric Protein	Ntrk1/Tropomyosin chimeric protein is encoded by the TRK gene, formed by a somatic rearrangement involving the neighboring genes for Neurotrophic Tyrosine Kinase Receptor type 1 and nonmuscle Tropomyosin.  Replacement of the receptor extracellular domain by nonmuscle Tropomyosin residues leads to transformation by the chimeric TRK oncogene product.  (from OMIM 164970 and NCI)
C18549	RAS_Superfamily_Protein	Small_G_Protein	RAS Superfamily Protein|Ras-Related Protein	Small cellular monomeric proteins with GTPase activity, RAS Superfamily Proteins are involved in signal transduction in normal cellular growth, differentiation, and development.
C18550	NF-Kappa_B_p49-p100_Protein	Transcription_Factor	NF-Kappa B p49/p100|H2TF1|LYT10 Protein|NF-kB Subunit 2|NF-kappa-B2|NF-kappaB(p50)|NFKB p49/p100 Subunit|NFKB2|NFKB2 Protein|Nuclear Factor Kappa B Subunit 2|Nuclear Factor Kappa-B Subunit 2|Nuclear Factor NF-Kappa-B P100 Subunit|Nuclear Factor of Kappa Light Chain Gene Enhancer in B-Cells 2|Transcription Factor NFKB2	NF-Kappa B p49/p100 is the precursor of the NFKB p52 subunit. NFKB2 belongs to the Rel/Dorsal family, contains seven ANK repeats, and binds to REL (p65) proteins to form NFKB, which is trapped in the cytoplasm by IkB proteins. IkB phosphorylation by IKBKA or IKBKB activates NFKB via destructive ubiquitination of IkBs. Activated transcription factor NFKB translocates to the nucleus and binds to the consensus Kappa-B enhancer DNA motif in immune response and acute phase reaction genes. (from SWISS-PROT Q00653, OMIM 164012, and NCI)
C18551	NTRK1_Gene	Receptor_Tyrosine_Kinase_Gene	NTRK1 Gene|MTC|NTRK1|Neurotrophic Tyrosine Kinase, Receptor, Type 1 Gene|TRK|TRKA	Human neurotrophic tyrosine kinase, receptor, type 1 (NTRK1) gene, located at 1q21-q22, encodes neurotrophic tyrosine kinase receptor type 1 protein. The 5'-untranslated region of this gene lacks a TATA box, but has putative binding sites for six transcription factors. Alternative splicing of this gene produces two protein isoforms that have similar biological properties. Defects in NTRK1 are associated with neoroblastomas and thyroid tumors.
C18552	ETS_Family_Protein	Transcription_Factor	ETS Family Protein|ETS Protein|ETS-Domain Transcription Factor	ETS family proteins exhibit sequence homology with the transcription factor ETS protooncogene.
C18553	SPI1_Gene	ETS_Family_Gene	SPI1 Gene|PU.1 Gene|SPI1|Spleen Focus Forming Virus (SFFV) Proviral Integration Oncogene SPI1 Gene|Spleen Focus Forming Virus Proviral Integration Gene 1	Expressed in all hematopoietic lineages, except T-cells, human SPI1 Gene (ETS Family) at 11p11.2 encodes 264-aa 30-kDa nuclear ETS-domain PU.1 Transcription Factor, essential for myeloid (osteoclast progenitors) and B-lymphoid cell development. SPI1 binds as a monomer to the purine-rich lymphoid-specific enhancer DNA PU-box (5'-GAGGAA-3'). Graded expression specifies distinct hematopoietic cell fates; low concentration induces B-cell fate, high concentration promotes macrophage differentiation.  SPI1 is required for p47-phox promoter activity in myeloid cells and its expression is increased with osteoclastogenesic induction by 1, 25-dihydroxyvitamin D3. SPI1 is thought to regulate FMS and CD18/11B transcription, central to the osteoclast phenotype. SPI1 is highly expressed in erythro-leukemia cells that have undergone SPI1 gene rearrangements due to SFFV insertion. (NCI)
C18554	TIAM1_Protein	Guanine_Nucleotide_Exchange_Factor	TIAM1 Protein|T-Lymphoma Invasion and Metastatis Inducing Protein 1|TIAM1	TIAM1 appears to function in cellular signaling by modulating activation the GDP-GTP exchange activity of RHO-like GTPases that regulate cytoskeletal organization.  The serine-rich TIAM1 protein contains a DH domain, a PDZ/DHR domain, and two PH domains.  The DH domain is found in GDP-GTP exchanger proteins that activate RHO-like GTPases and PH domains are thought to be involved in protein-protein interactions.  TIAM1 activates RAC1, CDC42, and to a lesser extent RHOA.  (from OMIM 600687 and NCI)
C18555	SPI1_Oncoprotein	Oncoprotein	SPI1 Oncoprotein	SPI1 is a putative oncogene specifically activated in acute murine erythroleukemias, induced by the Friend spleen focus forming virus.  It encodes PU.1, an ETS-domain transcription factor normally expressed in all hematopoietic lineages except in T-cells, and is essential for myeloid (osteoclast progenitors) and B-lymphoid cell development.  A low concentration of PU.1 induces the B-cell fate, whereas a high concentration promotes macrophage differentiation.  (from OMIM 165170 and NCI)
C18556	p61-YES	SRC_Family_Tyrosine_Kinase	p61-YES|YES1|YES1 Protein Tyrosine Kinase|c-yes Kinase	p61-YES is associated with tyrosine-specific protein kinase activity, shows a high degree of homology with SRC, and contains one SH2 domain and one SH3 domain. (from OMIM 164880, Swiss-Prot P07947, and NCI)
C18557	Transforming_Protein-ERG	ETS_Family_Protein	Transforming Protein ERG|ERG|ERG1|ERG2|Transcriptional Regulator ERG	A member of the ETS family of transcription factors closely related to FLI1, Transforming Protein ERG shows homology to two domains of the ETS oncogene.  ERG1 and ERG2 are products of alternative splicing and polyadenylation, as well as translation initiation.  ERG2 is a nuclear phosphoprotein that binds to purine-rich sequences.  Like other ETS proteins, ERG2 is a sequence-specific DNA-binding protein and expressed at higher levels in early myeloid cells than in mature lymphoid cells.  ERG2 acts as a regulator of genes required for maintenance and/or differentiation of early hematopoietic cells.  (from OMIM 165080 and NCI)
C18558	p60-HCK	SRC_Family_Tyrosine_Kinase	p60-HCK|B-cell/myeloid kinase|Hemopoietic Cell Kinase p60	May serve as part of a signaling pathway coupling the FC receptor to the activation of the respiratory burst.  Furthermore, it may also contribute to neutrophil migration and may regulate the degranulation process of neutrophils.  p60-HCK and p59-HCK are produced by alternative initiation from the same proto-oncongene HCK.  Both are expressed predominantly in cells of the myeloid and b-lymphoid lineages, thus also called B-cell/Myeloid kinase.  Contains 1 sh2 domain and 1 sh3 domain. Has been mapped to chromosomal location 20q11-q12.
C18559	TFAP2A_Gene	Transcription_Factor_Gene	TFAP2A Gene|AP-2|AP-2 Alpha Gene|AP2 Gene|AP2TF|Activator Protein 2 Gene|TFAP2|TFAP2A|Transcription Factor AP-2 Alpha (Activating Enhancer Binding Protein 2 Alpha) Gene	Human AP2 Gene (AP2 family) at 6p24 encodes AP-2, a dimeric 52 kD transcription factor that binds to 5 prime-GCCNNNGGC-3 prime sequence in the SV40 promoter and in cellular enhancer elements, such as the metallothionein gene.  The AP2 mRNA is derived from seven exons distributed over 18 kb.  Four isoforms may be produced by alternative splicing.  The promoter contains a consensus AP2 binding site and is subject to positive autoregulation.  An alternatively spliced form of AP2 does not bind the consensus site and inhibits AP2 binding.  AP2 can form homodimers, or heterodimers with other members of the AP2 family, and activates genes involved in a large spectrum of biological functions, including development.  AP2 factors also suppress many genes, including MCAM/MUC18, C/EBP-Alpha and MYC.
C18560	WNT1_Protein	WNT_Family_Protein	WNT1 Protein|WNT1|WNT1 Gene Product	WNT1 protein is a cysteine-rich secreted glycoprotein homologue of the Drosophila wingless segment-polarity gene product.  It is probably a signaling protein acting in CNS mesencephalon and metencephalon development.  (from OMIM 164820 and NCI)
C18561	WNT5A_Protein	WNT_Family_Protein	WNT5A Protein|WNT5A|WNT5A Gene Product	Encoded by human WNT5A Gene (WNT Family), 365-aa 41-kDa (precursor) WNT5A Protein, a cysteine-rich secreted glycoprotein growth factor, is involved in embryonic cell migration and axis induction. Frizzled-5 is a 7 transmembrane receptor for WNT5A ligand, which shows 98%, 98% and 87% amino acid identity to mouse, rat, and xenopus Wnt5A proteins. (NCI)
C18562	Thyroid_Hormone_Receptor_Gene	Transcription_Factor_Gene	Thyroid Hormone Receptor Gene|THR Gene	Thyroid Hormone Receptor Genes (Nuclear Receptor Family), c-erbA alpha and c-erbA beta, encode two isoforms each of c-erbA proteins (Thyroid Hormone Receptor) that specifically bind thyroid hormones and, thereby activated, regulate target gene transcription. (NCI)
C18563	WT2_Protein	Protein_with_Unknown_or_Unclassified_Function	WT2 Protein|Multiple Tumor-Associated Chromosome Region 1|WT2|WT2 Gene Product	The WT2 protein is the putative protein encoded by the WT2 gene, a second Wilms tumor suppressor gene locus.  Efforts to clone the WT2 gene(s) have not yet been successful.  (from OMIM and NCI)
C18565	BLYM_Oncoprotein	Oncoprotein	BLYM Oncoprotein	BLYM oncoprotein is the product of the BLYM oncogene, activated in certain human B lymphoid tumors.  BLYM contains regions of similarity to the amino terminal region of transferrins.
C18566	FLI1_Transcription_Factor	ETS_Family_Protein	FLI1 Transcription Factor|ERGB Transcription Factor|FLI1|FLI1 Protein|Friend Leukemia Virus Integration 1 Protein|Friend Leukemia Virus Integration 1 Transcription Factor	Similar to other ETS transcription factors, ERGB Transcription Factor (FLI1) regulates expression of the TGF-beta type II receptor gene.  FLI1 contains one PNT domain, can form homodimers or heterodimers with ETV6/TEL1, and recognizes the sequence C[CA]GGAAGT.  Two isoforms may be produced by alternative splicing.  A form of Ewing's sarcoma is characterized by the chromosomal translocation t(11;22)(q24;q12), which involves FLI1 and EWS. (NCI)
C18567	Apoptosis_Promoter	Apoptosis_Regulator	Apoptosis Promoter|Inducer of Apoptosis	Encoded by Apoptosis Promoter Genes, Apoptosis Promoter proteins promote the initiation, progress, or rate of apoptosis. (NCI)
C18568	Fibroblast_Growth_Factor_Gene_Family	Growth_Factor_Gene	Fibroblast Growth Factor Gene Family	The Fibroblast Growth Factor Gene Family encodes Fibroblast Growth Factor peptides, potent mitogens that stimulate mesodermal cell growth, including chondrocytes, granulosa, and endothelia, and may be active in wound healing and regeneration. (NCI)
C18569	FGF2_Gene	Fibroblast_Growth_Factor_Gene_Family	FGF2 Gene|Basic Fibroblast Growth Factor Gene|FGF2|FGFB|Fibroblast Growth Factor 2 (Basic) Gene	Widely expressed at low levels, human Fibroblast Growth Factor 2 Gene (FGF family) at 4q25-q27 encodes a wide-spectrum mitogenic/angiogenic/neurotrophic factor, highly expressed in brain and pituitary.  Basic FGF is encoded by a single gene split by at least two introns greater than 15 kb.  Monomeric FGF2 is implicated in limb development, angiogenesis, wound healing, tumor growth, and other processes.  Basic FGF binds heparin more strongly than acidic FGF, can influence anteroposterior neural pattern, and may be a posteriorizing inducer.  Cardiac mesoderm, which expresses FGF1, FGF2, and FGF8, causes liver development from the foregut endoderm.  (from SWISS-PROT, OMIM, and NCI)
C18570	FGF7_Gene	Fibroblast_Growth_Factor_Gene_Family	FGF7 Gene|FGF7|Fibroblast Growth Factor 7 (Keratinocyte Growth Factor) Gene|Fibroblast Growth Factor 7 Gene|HBGF-7|KGF|Keratinocyte Growth Factor Gene	Human Fibroblast Growth Factor 7 Gene (FGF family) at 15q15-q21.1 encodes 28 kD FGF7, which stimulates epithelial cell (predominantly keratinocyte) growth, but lacks mitogenic activity on fibroblasts or endothelial cells.  (from SWISS-PROT, OMIM, and NCI)
C18571	FGF5_Gene	Fibroblast_Growth_Factor_Gene_Family	FGF5 Gene|FGF5|Fibroblast Growth Factor 5 Gene	Expressed in neonatal brain, human Fibroblast Growth Factor 5 Gene (FGF family) at 4q21 has a three-exon structure typical for this family.  Two isoforms are produced by alternative splicing.  (from SWISS-PROT, OMIM, and NCI)
C18572	Proto-Oncogene_Growth_Factor_Receptor	Retired_Concepts	Proto-Oncogene, Growth Factor Receptor
C18573	RET-H4_Oncogene	Fusion_Gene	RET/H4 Oncogene|RET/D10S170 Oncogene|RET/PTC1 Oncogene|TST1 Oncogene|Transforming Sequence, Thyroid 1	The PTC1 chimeric oncogene (RET/PTC1, RET/H4) is generated by fusion of the RET proto-oncogene receptor tyrosine kinase domain to the 5-prime terminal region of the H4 gene containing a putative leucine zipper. H4 shows no significant homology to known genes and the protein function is unknown. The RET receptor ligand is Glial Cell Line-Derived Neurotrophic Factor. The putative H4 leucine zipper mediates dimerization of the PTC1 oncoprotein, essential for PTC1 transforming activity. (NCI)
C18574	Angiogenesis_Promoter	Regulatory_Protein	Angiogenesis Promoter	Natural factors which stimulate blood vessel production.
C18575	Insulin-Like_Growth_Factor-Binding_Protein-9	Insulin-Like_Growth_Factor-Binding_Protein	Insulin-Like Growth Factor-Binding Protein-9|IGFBP9|NOV	A product of the NOV gene.  It is a member of the CCN family of proteins, expressed after induction by growth factors.  CCN proteins share several motifs: an IGFBP motif, an oligomeric complex-forming domain, a binding domain for soluble and matrix molecules, and a dimerization CT domain.  All CCN members are thought to control cell proliferation.  (from OMIM 164958 and NCI)
C18576	MAX_Gene	Transcription_Factor_Gene	MAX Gene|MYC-Associated Factor X Gene	Human MAX Gene (MYC family) at 14q23 encodes MYC-Associated Factor X, a bHLH/ZIP transcription factor phosphoprotein.  At least three isoforms are produced by alternative splicing.  High levels are found in brain, heart, and lung; lower levels in liver, kidney, and skeletal muscle.  Unlike most immediate early genes like MYC, MAX mRNA is relatively stable and not modulated with respect to cell proliferation.  DNA binding by MAX requires dimerization with another bHLH protein.  MAX forms a transcription regulatory complex with MYC and with MAD that recognizes 5 prime-CAC(GA)TG-3 prime.  MYC/MAX is an activator; MAD/MAX is a repressor.  MAX binds to the MYC gene and DDX18, a DEAD box family member.  MAX also interacts with MIX2. (from SWISS-PROT, OMIM, and NCI)
C18577	TP73_Protein	Transcription_Factor	TP73 Protein|TP73|Tumor Protein p73|p53-Like Transcription Factor|p53-Related Protein p73	Product of the TP73 gene.  A p53 homologue.  It is independently activated from p53 and represents a separate route to apoptosis.
C18578	FPS-FES_Protein	Tyrosine-Protein_Kinase_FES-FPS	FPS-FES Oncoprotein	Human FPS-FES Protein is a product of a mutated variant (Oncogene FPS-FES) of FES Gene (FES/FPS Subfamily), which encodes 822 aa 93-kDa Tyrosine-Protein Kinase FES/FPS, a tyrosine-specific protein kinase involved in normal hematopoiesis and containing an FCH and SH2 domain. The FES chromosomal location is linked to a translocation identified in patients with acute promyelocytic leukemia. A truncated transcript is generated utilizing a start site in a far downstream exon. FPS-FES Protein disrupts normal cell function.
C18579	RUNX1_Gene	Transcription_Factor_Gene	RUNX1 Gene|AML1|AMLCR1|CBFA2|PEBP2A2|PEBP2aB|RUNX1|Runt-Related Transcription Factor 1 (Acute Myeloid Leukemia 1; AML1 Oncogene) Gene	Encodes core-binding factor alpha, part of the heterodimeric transcription factor Core-Binding Factor.  The CBFalpha subunit binds directly to the enhancer core DNA sequence on target genes, whereas the beta subunit does not bind the DNA directly but increases the affinity and stabilizes the binding of the alpha subunit to the DNA.  Three homologous genes can encode for the CBFalpha subunit.  Disruption of CBFA2 is associated with many leukemias, including AML, ALL, and CML.
C18580	PTTG1_Gene	Cell_Cycle_Gene	PTTG1 Gene|PTTG|PTTG1|Pituitary Tumor Transforming Gene|Pituitary Tumor-Transforming 1 Gene|TUTR1|hPTTG	The PTTG1 proto-oncogene affects cell cycle regulation, proliferation, and cellular transformation by its involvement in regulation of chromatid separation.  PTTG1 encodes a cytosolic, proline-rich protein with several SH3 sites and an N-terminal basic and C-terminal acidic domain.  The gene product is Securin, a likely Anaphase-Promoting Complex substrate associated with ESP1 until activation of APC.  Securin contains a conserved destruction (D) box motif shared by many APC substrates.  Securin may function through SH3-mediated signal transduction pathways and activation of growth factors.  Securin is essential for the maintenance of euploidy and its effect on chromatid separation takes place through its APC interaction.  PTTG1 is highly expressed in many tumors.
C18581	Securin	Cell_Cycle_Protein	Securin|EAP1|ESP1-Associated Protein 1|PTTG1|PTTG1 Gene Product	Product of the PTTG1 Gene.  It is an anaphase-promoting complex substrate, involved in regulation of chromatid separation.  Has effects on cell cycle regulation, cellular proliferation, and cellular transformation.  It is a cytosolic, proline-rich protein with several SH3 sites and N-terminal basic and C-terminal acidic domains.
C18582	Angiogenesis_Inhibitory_Protein	Regulatory_Protein	Angiogenesis Inhibitory Protein|Angiogenesis Inhibitor Protein	Angiogenesis inhibitory proteins are natural factors that block blood vessel production.
C18583	ATM_Gene	Serine-Threonine_Protein_Kinase_Gene	ATM Gene|AT Gene|AT1|ATA|ATC|ATD|ATDC|ATE|ATM|Ataxia Telangiectasia Mutated (Includes Complementation Groups A, C and D) Gene|Ataxia-Telangiectasia Gene|Ataxia-Telangiectasia Mutated Gene|Louis-Bar Syndrome Gene	Gene defective in Ataxia telangiectasia disease.  Results in a defect in cell cycle regulation and DNA repair.  Associated with sensitivity to DNA damaging agents such as ionizing radiation.
C18584	CBFB_Gene	Transcription_Factor_Gene	CBFB Gene|CBF-Beta Gene|CBFB|Core-Binding Factor, Beta Subunit Gene|PEBP2B	The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis and osteogenesis. The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. (from LocusLink)
C18585	MLL_Gene	Transcription_Factor_Gene	MLL Gene|ALL1|HRX|HTRX|MLL|Mixed Lineage Leukemia Gene|Myeloid-Lymphoid Leukemia Gene|Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila) Gene|TRX1	The 100 kb human MLL Gene (TRX family) at 11q23 contains at least twenty-one exons and encodes a 431 kD nuclear HRX protein.  Homologous to DNA methyltransferase and containing N-terminal AT-hook motifs, HRX has three regions of homology to trithorax (Drosophila), including cysteine-rich regions that fold into six zinc finger-like domains.  Expressed in heart, lung, brain, and T- and B-lymphocytes, the evolutionarily conserved MLL gene may be unique in the human genome.  With features of a DNA-binding protein, HRX may bind within the minor groove of AT-rich DNA and is a likely transcriptional regulator.  HRX localizes to nuclear structures, contains a bromodomain, a SET domain, three PHD zinc fingers, and a CXXC zinc finger.  The gene is frequently involved in rearrangements in AML.  (from SWISS-PROT, OMIM, and NCI)
C18587	Tumor_Promoter_Induced_Gene	Cancer_Gene	Tumor Promoter Induced Gene	Tumor promoter induced genes are expressed shortly after cell exposure to tumor promoters.
C18588	GSTM1_Gene	Transferase_Gene	GSTM1 Gene|GST1|GSTM1|Glutathione S-Transferase M1 Gene	A lung cancer modifier, human GSTM1 Gene (GST family) at 1p13.3 is expressed in adult liver, kidney, adrenal gland, and stomach and weakly in skeletal and cardiac muscle.  GSTM1 is not expressed in fetal liver, fibroblasts, erythrocytes, lymphocytes, and platelets.  Clustered 20 kb apart, four GST mu genes are arranged 5-prime--GSTM4--GSTM2--GSTM1--GSTM5--3-prime.  Mammalian cytosolic GSTs are divided into alpha, mu, kappa, theta, pi, and sigma classes; there is also a class of microsomal GSTs.  Glutathione S-transferases metabolize a broad range of hydrophobic electrophilic xenobiotics and carcinogens.  Dimeric cytoplasmic GST M1 catalyzes glutathione addition to organic compounds forming thioethers, often a detoxification reaction leading to mercapturic acid formation.  By increasing sensitivity to some carcinogens, GSTM1 absence may be a risk factor for cancer.  (from SWISS-PROT, OMIM, and NCI)
C18589	COMT_Gene	Methyltransferase_Gene	COMT Gene|COMT|Catechol-O-Methyltransferase Gene	The COMT gene is a human breast cancer modifier/susceptibility gene that encodes a member of the Catechol-O-Methyltransferase gene family.  COMT catalyzes the transfer of a methyl group from S-adenosylmethionine to catecholamines, such as dopamine, epinephrine, and norepinephrine, in a major degradative pathway.  In addition, COMT metabolizes catechol drugs used in the treatment of hypertension, asthma, and Parkinson disease.  The human gene is located at 22q11.21-22q11.23.
C18590	PMS1_Gene	DNA_Repair_Gene	PMS1 Gene|HNPCC3|PMS1|PMS1 Postmeiotic Segregation Increased 1 (S. cerevisiae) Gene|PMSL1|hPMS1	A cloned gene for Hereditary Non-Polyposis Colon Cancer, the PMS1 Gene (MUTL/HEXB family) at 2q31.1 is associated with colon, endometrial, and stomach cancers. The PMS1 gene encodes DNA Mismatch Repair Protein PMS1, which is implicated, with MSH2 and MLH1, in mismatch repair of dinucleotide and trinucleotide sequences. Human PMSL genes exhibit homology to bacterial mutL genes and yeast PMS1 gene. (From SWISS-PROT, OMIM, and NCI)
C18591	PMS2_Gene	DNA_Repair_Gene	PMS2 Gene|DNA Mismatch Repair Gene Homologue|HNPCC4|H_DJ0042M02.9|PMS2|PMS2 Postmeiotic Segregation Increased 2 (S. cerevisiae) Gene|PMSL2	Associated with colon, endometrial, and stomach cancers, the ubiquitously expressed PMS2 Gene (MUTL/HEXB family) at 7p22 consists of 15 exons that encode DNA Mismatch Repair Protein PMS2, involved with MSH2 and MLH1 in mismatch repair of dinucleotide and trinucleotide sequences. PMS2 is part of the BASC genome surveillance complex. MSH2 and MLH1 interact with PMS1, PMS2, and MSH6. Essential for repair of replication slippage errors, PMS2 is a cloned gene for Turcot syndrome and Hereditary Non-Polyposis Colon Cancer. Transcribed from the opposite strand, JTV1 overlaps PMS2. (From SWISS-PROT, OMIM, and NCI)
C18592	TGFBR2_Gene	Receptor_Serine-Threonine_Kinase_Gene	TGFBR2 Gene|HNPCC6|TGFBR2|Transforming Growth Factor, Beta Receptor II (70/80kDa) Gene	The tumor suppressor TGFBR2 gene is a cloned gene for Hereditary Non-Polyposis Colon Cancer that encodes a putative transforming growth factor beta receptor II, a serine/threonine kinase receptor family member.  TGFBR2, a heteromeric complex, mediates growth inhibition of many epithelial cell types and hypophosphorylation of RB; loss of this negative regulation is thought to contribute to tumor development.  The TGFBR2 gene is regulated by ETS transcription factors and is a likely target of the EWS-FLI1 fusion protein found in Ewing sarcoma.  The human gene is located at 3p22.
C18593	Cyclin-Dependent_Kinase_Inhibitor_Gene	Cell_Cycle_Gene	Cyclin-Dependent Kinase Inhibitor Gene|CDK Inhibitor Gene	The CDK Inhibitor Genes encode the CDK Inhibitor Proteins, a group of low molecular weight proteins that associate with cyclin-CDK complexes or CDKs alone and inhibit their activity. (From OMIM and NCI)
C18594	BLCA-4	Nuclear_Matrix_Protein	BLCA-4|Bladder Cancer Specific Nuclear Matrix Protein BLCA-4	BLCA-4 is a bladder-specific, nuclear matrix protein.  Elevated levels of BLCA-4 in the urine may identify individuals with bladder cancer. (from J Urol 2000. 164:634-639 via Medscape)
C18595	Susceptibility-Resistance_Gene	Cancer_Gene	Susceptibility/Resistance Gene	Genes that make a person more or less resistant to a disease. These genes respond in special ways to certain extrinsic stimuli and thus tend to make the individual more than usually susceptible to certain diseases.
C18596	Ultrastructural_Pathology	Histopathology	Ultrastructural Pathology	The study and description of the fine structural changes that result from disease processes.
C18597	DNA_Binding	Nucleic_Acid_Binding	DNA Binding|DNA Binding Interaction	Used in reference to proteins or low molecular weight solutes (ligands) that interact specifically with DNA, in either a DNA-sequence dependent or independent fashion.
C18598	Apoptosis_Inhibitor	Apoptosis_Regulator	Apoptosis Inhibitor	Encoded by Apoptosis Inhibitor Genes, Apoptosis Inhibitor proteins impede the initiation, progress, or rate of apoptosis. (NCI)
C18599	Biomarker_of_Dietary_Intake	Metabolic_Marker	Biomarker of Dietary Intake	Dietary induced changes in the serum metabolome which serve as biomarkers for physiological status (e.g., relative risk of developing age-related diseases such as cancer).
C18600	PIM-1_Serine-Threonine_Kinase	Serine-Threonine_Protein_Kinase	PIM-1 Serine/Threonine Kinase|PIM1	The proto-oncogene PIM1 encodes a putative cytosolic serine/threonine protein kinase, up regulated in prostate cancer. The gene is highly expressed in the liver and spleen during fetal hematopoiesis and primarily in B-lymphoid and myeloid cell lines.  (from OMIM 164960 and NCI)
C18601	PVT1_Protein	Protein_with_Unknown_or_Unclassified_Function	PVT1 Protein|PVT1|PVT1 MYC Activator	The PVT1 protein is a product of the PVT1 gene, involved in some human Burkitt lymphomas, and a putative activator of MYC.  (from OMIM 165140 and NCI)
C18602	Chromatin_Remodeling_Factor	Regulatory_Protein	Chromatin Remodeling Factor|Chromatin Remodeling Complex	The protein complexes or individual proteins that have the function of chromatin remodeling. (NCI)
C18603	FURIN_Gene	Protease_Gene	FURIN Gene|FUR|FURIN|Furin (Paired Basic Amino Acid Cleaving Enzyme) Gene|PACE Gene|PCSK3|Paired Basic Amino Acid Cleaving Enzyme Gene|SPC1	The PACE gene encodes paired basic amino acid cleaving enzyme, a ubiquitous proprotein endoprotease that functions within secretory pathways and is localized to the trans Golgi network.  PACE cleaves at RX(K/R)R consensus motifs in the proteolytic activation of pro-proteins and plays a significant role in tumor progression.  The human gene is located at 15q25-q26.
C18604	Oncogene_MAX	MAX_Gene	Oncogene MAX|MAX	Oncogene MAX is a member of the MYC gene family. The MAX gene encodes a bHLH/ZIP protein that forms a heterodimer with MYC and binds with high affinity to a DNA site in the MYC gene and DDX18, a DEAD box family member. MAX mRNA steady state level is not modulated with respect to cell proliferation or differentiation, unlike mRNAs encoded by most immediate early genes. MAX also interacts with MIX2. The human gene is located at 14q23.
C18605	Patched	Cell_Surface_Receptor	Patched|PTCH	Patched is the sonic hedgehog receptor, a protein with twelve transmembrane domains that represses transcription of genes encoding TGF Beta and WNT family signaling proteins.  Patched is involved in embryonic development and adult cell growth control.  Sonic hedgehog binding to Patched appears to activate the 7-transmembrane protein Smoothened by release from Patched inhibition.  Basal cell carcinoma is associated with mutations that activate Smoothened or inactivate Patched, causing excess activity of the hedgehog response pathway.  The PTCH gene is a cloned gene for Basal Cell Nevus Syndrome, associated with skin cancer and childhood brain cancer.  (from OMIM 601309 and NCI)
C18606	Ephrin_Receptor	Receptor_Tyrosine_Kinase	Ephrin Receptor|EPH	Eph receptor tyrosine kinases and their ligands, the ephrins, appear to lie functionally at the interface between pattern formation and morphogenesis.  They play a major role in axonal pathfinding and target recognition during central nervous system (CNS) development.  (from Development 1999;126:2033-2044 and Exp Neurol 1999;156:218-22)
C18607	TM4SF1_Gene	Gene_with_Unknown_or_Unclassified_Function	TM4SF1 Gene|L6|M3S1|TM4SF1|Transmembrane 4 L Six Family Member 1 Gene	This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. (from LocusLink)
C18608	HOX11_Gene	Homeobox_Gene	TLX1 Gene|HOX11|Homeobox 11 Gene|T-Cell Leukemia, Homeobox 1 Gene|T-Cell Lymphoma 3-Associated Breakpoint Gene|TCL3|TCL3 Gene|TLX1	Human HOX11 Gene (HOX family) at 10q24 encodes HOX11 Protein, a homologue of DNA-binding homeobox transcription factors.  Located outside the four HOX clusters, HOX11 is an orphan homeobox gene.  Orthodox HOX genes encode a coordinate system of embryonic anterior-posterior axis specification; orphan homeobox genes are less understood.  Essential for survival of splenic precursors during organogenesis, HOX11 binds to 5 prime-GGCGGTAAGTGG-3 prime DNA.  Mutant HOX11 can be oncogenic; some childhood T-cell acute leukemias involve deregulated activation (by translocation adjacent to TCRD or TCRB) of an unaltered HOX11 gene. (from SWISS-PROT, OMIM, and NCI)
C18609	C-KIT_Gene	Receptor_Tyrosine_Kinase_Gene	KIT Gene|C-KIT|CD117|KIT|SCF Receptor Gene|SCFR|Stem Cell Factor Receptor Gene|V-Kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog Gene	A cloned gene for Familial Gastrointestinal Stromal Tumor, the 70 kb human C-KIT Gene (CSF1R/PDGFR family) at 4q11-q12 encodes a transmembrane receptor tyrosine kinase for SCF.  It is critical in pluripotent hematopoietic stem cell development, migrating embryonic melanoblasts, and primordial germ cells.  Located within 700 kb of PDGFRA, c-KIT includes twenty-one exons and is alternatively spliced; the longest transcript is 5.2 kb.  The overall gene structure resembles that of CSF1R.  (from SWISS-PROT, OMIM, and NCI)
C18610	Pharmacology_Other	Pharmacology	Pharmacology, Other
C18611	Metabolic_Pathways	Biochemical_Pathway	Metabolic Pathway|Metabolic Pathways|Metabolism	An elaboration of the known steps and interactions for the metabolism of a compound.
C18612	Office_of_Administrative_Management	Component_of_the_National_Institutes_of_Health	Office of Administrative Management|Administrative Management	The Office of Administrative Management, develops and executes the administrative, fiscal, and management aspects of (institute) programs. The Office of Administrative Management plans and directs the day-to-day administrative functions of (the institute) through the following sections: administrative management; financial management; grants and contracts management; and personnel management. (from NHGRI: Mission Statement and Organization October 1995)
C18613	Academic_Career_Award	Academic_Teacher_Award	Academic Career Award|K07 Award	To create and encourage a stimulating approach to disease curricula that will attract high-quality students, foster academic career development of promising young teacher-investigators, develop and implement excellent multidisciplinary curricula through interchange of ideas, and enable the grantee institution to strengthen its existing teaching program. (Grant Guidelines and Descriptions, NCI)
C18614	Academic_Grants_and_Contracts_Administration	Grants_and_Contracts_NIH	Academic Grants and Contracts Administration	Oversight and management of grants or contracts
C18615	Acute_Illnesses_Nursing	Nursing	Acute Illnesses Nursing	A subdiscipline of nursing focusing on care for patients with short term illnesses.
C18616	Administrative_Supplements_to_Research_Grants	Institution_Supplementation|Research_Support	Administrative Supplements to Research Grants	These provide administrative supplements to existing NIH research grants for the purpose of 1) promote reentry into biomedical and behavioral research careers 2) promote the recruitment of individuals with disabilities into biomedical research careers and 3) attract underrepresented minorities into biomedical and behavioral research.
C18617	Adult_Health_Nursing	Nursing	Adult Health Nursing	A subdiscipline of nursing focusing on general and comprehensive nursing care directed to adults.
C18618	Aging_Other	Retired_Concepts	Aging, Other
C18619	AIDS_Epidemiology	Epidemiology	AIDS Epidemiology	Study of the occurrence, distribution, and containment of the acquired immunodeficiency syndrome (AIDS).  Used for the scientific discipline as a whole or for specific epidemiological factors or findings (e.g., AIDS incidence or prevalence statistics). (from PSY94)
C18620	AIDS_Population	Population_Group	AIDS Population	Subgroups of AIDS patients.
C18621	AIDS_Related_Research_Women	Research_Funding_Categories	AIDS Related Research, Women	AIDS related research with a minimum of 20% research efforts related to females 12 years of age or older. To include: Pregnant women, Women at risk of HIV infection, Transmission of HIV between heterosexual partners, Female prostitutes, Perinatal transmission of HIV. (FMB)
C18622	AIDS_Black	AIDS_Treatment_Research	AIDS, Black	AIDS related research with a minimum of 20% (or $100,000) relevance to individuals of African descent
C18623	AIDS_Hispanic	AIDS_Treatment_Research	AIDS, Hispanic	AIDS related research with a minimum of 20% (or $100,000) relevance to individuals of Mexican, Cuban, Puerto Rican, Central American, or South American descent.
C18624	AIDS_Homosexual	AIDS_Treatment_Research	AIDS, Homosexual	AIDS related research with a minimum of 20% (or $100,000) relevance to individuals of homosexual orientation
C18625	AIDS_International	AIDS_Treatment_Research	AIDS, International	AIDS related research with a minimum of 20% (or $100,000) research efforts related to foreign countries.  To include: Awards to scientists or organizations outside the U.S.A.; awards to international organizations such as WHO and PAHO; Projects where at least 20% (or $100,000) of the funds are related to training a U.S. scientist outside the U.S.A or a non-U.S. scientist in the U.S.A.; Projects where at least 20% (or $100,000) of the activity takes place outside the U.S.A.; Projects where at least 20% (or $100,000) of the funds are related to international exchange or international travel.
C18626	AIDS_Minority	AIDS_Treatment_Research	AIDS, Minority|Minority AIDS	AIDS related research with a minimum of 20% (or $100,000) research efforts related to individuals of non-Caucasian descent, and individuals of Hispanic descent.
C18627	AIDS_Other_Minorities	AIDS_Treatment_Research	AIDS, Other Minorities	AIDS related research with a minimum of 20% (or $100,000) relevance to individuals who are Asian/Pacific Islanders or Native Americans, including American Indians, Alaskan Natives, and Hawaiian Natives.
C18628	AIDS_Women	AIDS_Treatment_Research	AIDS, Women	AIDS related research with a minimum of 20% (or $100,000) research efforts related to females 12 years of age or older. To include: Pregnant women, Women at risk of HIV infection, Transmission of HIV between heterosexual partners, Female prostitutes, Perinatal transmission of HIV.
C18630	Allied_Health_Sciences_Education_and_Training	Training_and_Education	Allied Health Sciences Education and Training
C18631	Allied_Health_Sciences_Other	Allied_Health_Sciences	Allied Health Sciences, Other	Occupations of medical personnel who are not physicians, and are qualified by special training and, frequently, by licensure to work in supporting roles in the health care field. These occupations include, but are not limited to, medical technology, physical therapy, physician assistant, etc.
C18632	Analytical_Biochemistry	Biochemistry	Analytical Biochemistry	Scientific discipline concerned with the development of methods and application of these methods to detect, identify, and quantify biological materials (e.g., proteins, nucleic acids, metabolites).  See analytic chemistry.
C18633	Animal_Genetics	Genetics	Animal Genetics	The study of genetic traits in animals.
C18634	Animal_Sources	Business_Rules	Animal Sources
C18635	Academic_Research_Enhancement_Award	Research_Project_Grants	Academic Research Enhancement Awards (Area)|AREA|Academic Research Enhancement Awards|R15 Mechanism|R15 Program
C18636	Auditory_Physiology	Sensory_Physiology	Auditory Physiology	The science concerned with the normal processes of hearing
C18637	Auditory_Psychophysics	Psychobiology	Auditory Psychophysics	Studies of the interactions between mind and physiology in relation to hearing perception.
C18638	Autoradiography_Microscopic	Autoradiography	Autoradiography, Microscopic	Autoradiographic analysis performed by mounting the object for microscopy (e.g., on a glass slide) and bathing the object with a photographic emulsion that will record radioactive disintegrations occurring at close proximity.
C18639	Autoradiography_Quantitative	Autoradiography	Autoradiography, Quantitative	Autoradiographic analysis performed following certain guidelines that will result in a defined correspondence between the intensity of the autoradiographic image and the amount of radioactivity present in the sample.  This permits assigning a value to the amount of (radioactive) material in the object under study.
C18640	Bioassay_in_vitro	Bioassay	Bioassay, in vitro	A procedure for analysis of biological activity of a substance by studying its effect in an experimental situation outside the organism, eg. in the test tube rather than in living systems.
C18641	Bioassay_in_vivo	Bioassay	Bioassay, in vivo|in vivo Bioassay|in vivo test	The appraisal of the biological properties or activities of a substance by testing its effect on an organism.
C18642	Biochemical_Endocrinology	Endocrinology	Biochemical Endocrinology	The study of the chemistry of endocrine hormones in living organisms.
C18643	Biochemical_Energetics	Biochemistry	Biochemical Energetics	The study of the energy changes involved in physical and chemical reaction, changes, and systems of living organisms.
C18644	Biochemical_Epidemiology	Epidemiology	Biochemical Epidemiology|Epidemiology, Biochemical	Biochemical epidemiology incorporates the collection of biologic specimens in epidemiologic investigations, which can be analyzed by laboratory techniques to gain better insights into specific environmental and genetic determinants of disease, precursor states, and the pathogenic mechanisms.
C18645	Enzymology	Biochemistry	Enzymology|Biochemistry, Enzymatic	The branch of biochemistry dealing with the chemical nature and biological activity of enzymes.
C18646	Biochemistry_Other	Biochemistry	Biochemistry, Other
C18647	Bioengineering_Other	Bioengineering	Bioengineering, Other
C18648	Bioinstrument_Application_and_Development	Research_Funding_Categories	Bioinstrument Application and Development
C18649	Biological_Testing	Techniques	Biological Testing	Testing performed to determine the effects of substances upon living organisms.
C18650	Biology_of_HIV_Infection	Virology_and_Immunopathogenesis_of_HIV	Biology of HIV Infection	Delineate the molecular and cellular mechanisms of establishment and systemic spread of infection and their impact on disease progression.
C18651	Biology_Other	Biology	Biology, Other
C18652	Biomedical_Research_Careers_Notice	Program_Announcements	Biomedical Research Careers, Notice
C18653	Biomolecule_Separations_Technology	Research_Techniques	Biomolecule Separations Technology	Techniques for separation of biomolecules from suspensions or mixtures based on physical and chemical properties.  Examples include: ion exchange columns, gel filtration methods, affinity chromatography, HPLC, aqueous two phase partitioning and membrane separation.
C18654	Biophysics_Bioengineering_and_Instrumentation	Biophysics	Biophysics, Bioengineering and Instrumentation	Techniques, specialties or disciplines for the development or modification of apparatus, instruments, or equipment for diagnostic or therapeutic procedures, analytic or other biological use.
C18655	Biophysics_Other	Biophysics	Biophysics, Other	A value used as a form filler when no specified type of Biophysics is appropriate.
C18656	Biotechnology_Fermentation	Biotechnology	Biotechnology, Fermentation	Development of fermentation processes for the biotech industry.
C18657	Biotechnology_Mass_Cell_Culture	Cell_Culture	Biotechnology, Mass Cell Culture	Techniques using equipment such as a hollow fiber apparatus or roller bottles for high volume maintenance or growth of animal, plant, or insect cells in vitro.
C18658	Biotechnology_Synthetic_Nucleic_Acid_Peptide	Biotechnology	Biotechnology, Synthetic Nucleic Acid Peptide
C18659	Bishop-Calabresi_Report	Program_Review_Group_Report	Bishop-Calabresi Report	A report by the Ad Hoc Working Group of the National Cancer Advisory Board presented on June 9, 1995, outlining, in detail, the state of the intramural research program of the National Cancer Institute.  The Ad Hoc Working Group was headed by J. Michael Bishop and Paul Calabresi.
C18660	Bone_and_Connective_Tissue_Pathology	Pathology	Bone and Connective Tissue Pathology	The branch of pathology that focuses the causes and nature and effects of diseases of the bone and connective tissues.
C18661	Bone_and_Connective_Tissue_Physiology	Physiology	Bone and Connective Tissue Physiology
C18662	Breast_Cancer_Education	Patient_or_Public_Education	Breast Cancer Education|Breast Cancer, Education	Programs or materials to provide information on breast cancer prevention, detection, or treatment to health professionals, patients and their families, the public, or high-risk groups.
C18663	Breast_Cancer_Genetics	Medical_Genetics	Breast Cancer Genetics|Breast Cancer, Genetics	Breast cancer genetics involve clinical, epidemiologic and/or laboratory evaluations of individuals and their families who are at high risk of developing breast cancer due to hereditary predisposition.  These studies are aimed at identifying susceptibility genes for breast cancer and their associated molecular and genetic aberrations, as well as the functions of their encoded proteins.
C18664	Breast_Cancer_Treatment_and_Rehabilitation	Retired_Concepts	Breast Cancer, Treatment and Rehabilitation|Breast Cancer, Rehabilitation and Treatment	Examples: surgical reconstruction, less mutilating surgery, psychological counseling.
C18665	Breast_Cancer_Epidemiology	Cancer_Epidemiology	Breast Cancer Epidemiology|Breast Cancer, Epidemiology	Environmental or molecular epidemiology of human breast cancer.
C18666	Cancer_Biology	Cancer_Science	Cancer Biology|Biology of Cancer	The study of the origins, growth, and treatment of any of various types of malignant neoplasms, most of which invade surrounding tissues, may metastasize to several sites, and are likely to recur after attempted removal and to cause death of the patient unless adequately treated; especially, any such carcinoma or sarcoma, but in ordinary usage, especially the former.
C18667	Office_of_Cancer_Information_Communication_and_Education	Office_of_Communications	Office of Cancer Information, Communication, and Education|OCICE	The Office of Cancer Communications supports a nationwide network of offices known as the Cancer Information Service (CIS). The CIS serves as the NCI's primary mechanism to disseminate accurate up-to-date information to the American public at the communit
C18668	Cancer_Epidemiology	Epidemiology	Cancer Epidemiology	Cancer epidemiology involves the study of how physical surroundings, occupational hazards and personal habits (smoking, diet and lifestyle) may contribute to the development of cancer. (Glossary of Cancer-Related Terms; http://www.meritcare.com)
C18669	Cancer_Etiology	Etiology	Cancer Etiology|Cancer Cause	Study of the causes and origins of cancer(s). (from PSY94)
C18670	Cancer_Immunology	Cancer_Biology	Cancer Immunology	Research that contributes to the understanding of the role of the immune system in controlling the development, growth, and spread of tumors, and includes studies of the basic transplantation biology relevant to tumor rejection and to immune reconstitution.  Includes technologies to facilitate this research.
C18671	Cancer_Prevention_Fellowship_Program	Fellowship_Programs	Cancer Prevention Fellowship Program|Cancer Prevention Fellowship Program (CPFP)|Fellowship Programs, Cancer Prevention	The Cancer Prevention Fellowship Program provides for: Master of Public Health training, participation in the Cancer Prevention and Control Academic Course, mentored research, and brief field assignments in cancer prevention or cancer control programs at other institutions (from Cancer Prevention Fellowship Program/Description)
C18672	Cancer_Prognosis	Prognosis	Cancer Prognosis	A forecast of the probable course and outcome of a cancer.
C18673	Cancer_Survivor	Survivor	Cancer Survivor|Survivor, Cancer	An individual who has survived a cancer, and is in a disease free, chronic, or relatively stable stage.
C18674	Cancer_Survivorship	Survival	Cancer Survivorship|Survivorship, Cancer	Research on cancer survivors, covers the full spectrum of biomedical and psycho-social issues that arise at the point of discontinuation of cancer-specific therapy to the point of terminal diagnosis (6 months or less to live).
C18675	Cancer_Viral	Cancer_Biology	Cancer, Viral	Virus as an agent in the cause of a cancer.
C18676	Carbohydrate_Biochemistry	Biochemistry	Carbohydrate Biochemistry	The study of the biological and physiological chemistry of carbohydrates.
C18677	Carbohydrate_Chemistry	Organic_Chemistry	Carbohydrate Chemistry	Chemistry of molecules having the form Cn(H2O)n
C18678	Biological_Carcinogenesis	Carcinogenesis_Mechanism	Biological Carcinogenesis	Studies of the role of biological agents as factors or cofactors in the etiology of human and animal cancer.
C18679	Carcinogenesis_Co-Carcinogenesis	Cancer_Biology	Carcinogenesis, Co-Carcinogenesis|Co-Carcinogenesis	These are studies which use more than one type of agent to induce cancer, where one agent alone does not induce cancer, but it does when in combination with others.
C18680	Hormonal_Carcinogenesis	Biological_Carcinogenesis	Hormonal Carcinogenesis|Carcinogenesis, Hormonal	The study of the role of hormones and hormonal action in the development of cancer.
C18681	Carcinogenesis_Mechanism	Cancer_Biology	Carcinogenesis Mechanism|Carcinogenesis, Mechanism	Research concerned with the metabolism, toxicity, physiological disposition, and mechanisms of action of carcinogens and their metabolites.
C18682	Physical_Carcinogenesis	Carcinogenesis_Mechanism	Physical Carcinogenesis|Carcinogenesis, Physical	Studies to identify the mechanisms by which physical agents cause cancer
C18683	Carcinogenesis_Radiation	Physical_Carcinogenesis	Carcinogenesis, Radiation|Radiation / Carcinogenesis|Radiation Carcinogenesis	The study of the processes by which normal cells, exposed to ionizing radiation, are transformed into cancer cells.
C18684	Cardiopulmonary_Physiology	Physiology	Cardiopulmonary Physiology	Study of the functions and activities of the cardiopulmonary system as a whole or of any of its parts.
C18685	cDNA_Library_Construction	Gene_Cloning	cDNA Library Construction	Methods for building collections of cloned DNA consisting of DNA copies of all the mRNAs produced by a cell type.  cDNAs are generated using reverse transcriptase and either an oligo-dT or random primer.  The copies are inserted into a bacterial plasmid or bacteriophage vector.  The library can be maintained as a pooled population or as an arrayed library.
C18686	cDNA_Subtraction	Molecular_Biology_Techniques	cDNA Subtraction	A difference cloning method and a technique for comparison of two closely related cell types, e.g. a differentiated or transformed cell (tester) and the undifferentiated or normal cell (driver). Driver RNA is converted to double-strand cDNA, usually with the incorporation of a tagged nucleotide, while the tester RNA is converted to first-strand cDNA (with no tag). The two preparations are mixed, melted and annealed to form, among other species, heteroduplexes composed of one strand from each of the different sources. The annealed heteroduplexes, as well as other driver species are captured by the tagged nucleotide and removed from the mixture. The resulting pool will be enriched for those cDNA species unique to the tester cells. Following second-strand synthesis, the double-stranded cDNAs are cloned. The resulting cDNA library will be enriched for sequences expressed only in the tester cells. cDNA subtraction can also be done by PCR. (NCI/OSP)
C18687	cDNA_Expression	Molecular_Biology_Techniques	cDNA Expression	CDNA expressed as protein formation
C18688	Cell_Biology_Other	Cell_Biology	Cell Biology, Other
C18689	Cell_Cycle_Checkpoint	Cell_Cycle_Regulation	Cell Cycle Checkpoint	Cell cycle checkpoints are phases or points in the cell cycle at which a cell is prevented from progressing into the next phase of the cycle unless certain necessary and sufficient cellular conditions exist.  The checkpoints help maintain the proper order and timing of cell transition events, especially important for DNA replication and chromosome segregation.
C18690	Cellular_Immunology	Immunology	Cellular Immunology|Immunology, Cellular	The cells in the body and how they are involved in immunity
C18691	Cerebrovascular_Physiology	Physiology	Cerebrovascular Physiology	A medical specialty focusing on the normal blood circulation of the brain and on changes due to pathology.
C18692	Cervical_Cancer_Education	Patient_or_Public_Education	Cervical Cancer Education	Programs or materials to provide information on cervical cancer prevention, detection, or treatment to health professionals, patients and their families, the public, or high-risk groups.
C18693	Chemistry_Other	Chemistry	Chemistry, Other
C18694	Chemistry_Quantitative	Analytical_Chemistry	Quantitative Chemistry|Chemistry, Quantitative	Measuring the amount of reagents, energy, radiation or product that was involved with a chemical reaction
C18695	Chicken_Cells	in_vitro_Model	Chicken Cells	Cells derived from the chicken used as a biological model for research.
C18696	Child_and_Family_Social_Services	Social_Work	Child and Family Social Services
C18697	Chromosome_Rearrangement_Detection	Genetic_Techniques	Chromosome Rearrangement Detection	Staining of metaphase spreads for crossovers, inversions, and translocations.  Includes karyotyping, fluorescence in situ hybridization, and chromosome painting. (NCI/OSP)
C18698	Chromosome_Transfer	Genetic_Techniques	Chromosome Transfer	The technique whereby chromosomes are exchanged among cells.
C18699	Clinical_Dental_Sciences_Other	Dental_Sciences_Clinical	Clinical Dental Sciences, Other
C18700	Clinical_Endocrinology	Endocrinology	Clinical Endocrinology	The clinical specialty of endocrinology that focuses on the endocrine organs and their role in physiology and pathology.
C18701	Clinical_Immunology	Clinical_Sciences|Immunology	Clinical Immunology	The medical field that deals with immune diseases, including autoimmune diseases, allergies, rejection of organ transplants and immune deficiency.
C18702	Clinical_Microbiology	Clinical_Sciences|Microbiology	Clinical Microbiology	The discipline focusing on microbe-induced clinical conditions, including epidemiology, pathogenesis, diagnosis and detection, and prevention and treatment.
C18703	Clinical_Nursing_Care_Other	Clinical_Nursing	Clinical Nursing Care, Other
C18704	Clinical_Nursing_Sciences_Other	Nursing_Sciences_Clinical	Clinical Nursing Sciences, Other
C18705	Clinical_Parasitology	Clinical_Sciences|Parasitology	Clinical Parasitology	A specialty in biology and medicine focusing on aspects of human parasitology that directly pertains to parasite-induced clinical conditions, including epidemiology, pathogenesis, diagnosis and detection, and prevention and treatment.
C18706	Clinical_Sciences	Health_Sciences	Clinical Sciences
C18707	Clinical_Trials_Adjunct	Grants	Adjunct Clinical Trial|Clinical Trial, Adjunct|Clinical Trials, Adjunct	A grant that uses materials from some other clinical trial.
C18708	Clinical_Virology	Clinical_Sciences|Virology	Clinical Virology	A subdiscipline of virology focusing on aspects of human virology that directly pertains to virus-induced clinical conditions, including epidemiology, pathogenesis, diagnosis and detection, and prevention and treatment.
C18712	Colloquia_Series_Including_Statistical_Colloquia	Conference	Colloquia Series, Including Statistical Colloquia
C18713	Combinatorial_Synthesis_of_Biomolecules	Combinatorial_Synthesis	Combinatorial Synthesis of Biomolecules	Technique for making and testing many complex materials in parallel: computer guided synthesis in which all possible combinations are made. Combinatorial synthesis is not random, but systematic and repetitive, using sets of chemical "building blocks" to form a diverse set of molecular entities.  Initial synthesis is usually made on a solid substrate. The technique lays down the materials in a checkerboard arrangement, as thin squares arranged in a grid.  Scientists use combinatorial chemistry to create large populations of molecules, or libraries, that can be screened efficiently en masse. (NCI/OSP)
C18714	Communication_Research	Research_Funding_Categories	Communication Research
C18715	Comparative_Biochemistry	Comparative_Biology	Comparative Biochemistry	The study of the similarities and differences between different living organisms of the biological and physiological chemistry of the organisms. Used for the scientific discipline or the biochemical processes themselves. (from PSY94)
C18716	Computer_Sciences_Other	Computer_Sciences	Computer Sciences, Other
C18717	Concept_Review	Funding	Concept Review
C18718	Conference_Grant_Guidelines	Award_Guidelines	Conference Grant Guidelines
C18719	Conjugated_Carrier	Drug_Vehicle	Conjugated Carrier	Chemically-modified substances, usually proteins, to target a compound to a site.
C18720	Consequences_of_HIV	AIDS_Treatment_Research	Consequences of HIV	Support research for the discovery, development, and evaluation of strategies for preventing or minimizing the negative physical, psychological, cognitive, and social consequences of HIV, including stigmatization of persons with or at risk for HIV infection. Support research strategies for promoting effective health care utilization among persons with HIV infection
C18721	Consumer_Liaison	Miscellaneous_Occupations	Consumer Liaison
C18722	Contracts_Review	Funding	Contracts Review
C18723	Coordinating_Center_Administration	Coordination_and_Collaboration	Coordinating Center Administration
C18724	Coordination_and_Collaboration	Research_Support	Coordination and Collaboration	Support research for the discovery, development, and evaluation of strategies for preventing or minimizing the negative physical, psychological, cognitive, and social consequences of HIV, including stigmatization of persons with or at risk for HIV infection. Support research strategies for promoting effective health care utilization among persons with HIV infection.
C18725	Culturally_and_Economically_Diverse_Group	Population_Group	Culturally and Economically Diverse Group	Groups of individuals that exhibit differing characteristic behavior in customs, attitudes, practices, and behaviors, or are predisposed to certain health histories due to differences in ethnicity, race, religion, national origin, or economic standing (DCCPS)
C18726	Cyclic_Nucleotide_Biochemistry	Nucleotide_Biochemistry	Cyclic Nucleotide Biochemistry	The study of the biological and physiological chemistry of cyclic nucleoside monophosphates.
C18727	Cyclic_Nucleotide_Pharmacology	Pharmacology_Biologicals	Cyclic Nucleotide Pharmacology	The science concerned with the chemistry, actions, and uses of cyclic nucleoside monophosphates.
C18728	Cytidylyltransferase	Nucleotidyltransferase	Cytidylyltransferase|Cytidyl Transferase	A family of enzymes that catalyze the transfer of a phosphate group using CTP as the donor molecule (EC 2.7.7.x)
C18729	Data_Base_Management	Data_Management	Data Base Management	Database management involves the design and maintenance of electronic data storage systems to facilitate and optimize the categorization, selection, and retrieval of information.
C18730	Dental_Epidemiology	Epidemiology	Dental Epidemiology|Oral Health Epidemiology	Studies into the link between dental and oral health and systemic disease.  Oral health problems have been associated with an increased risk for a variety of systemic diseases including cardiovascular disease, respiratory disease, preterm and low birth weight infants, and earlier death.  Studies are needed that evaluate physiological pathways that connect oral and systemic conditions.  (Oral and Dental Epidemiology: http://www.hsph.harvard.edu/epidemiology/academics/oralepi.htm)
C18731	Dental_Sciences_Clinical	Clinical_Sciences	Dental Sciences, Clinical
C18732	Development-Other	Organismal_Process	Development, Other	Processes that involve and promote formation of more mature organs, organ systems, or organisms; general development. (NCI)
C18733	Developmental_Biochemistry	Biochemistry	Developmental Biochemistry
C18734	Developmental_Cell_Biology	Developmental_Biology	Developmental Cell Biology
C18735	Developmental_Endocrinology	Developmental_Biology|Endocrinology	Developmental Endocrinology
C18736	Developmental_Physiology_Differentiation_Growth	Physiology	Developmental Physiology Differentiation/Growth
C18737	Developmental_Psychology_Adolescence	Developmental_Psychology_General	Developmental Psychology, Adolescence
C18738	Developmental_Psychology_Adult	Developmental_Psychology_General	Developmental Psychology, Adult
C18739	Developmental_Psychology_Aged	Developmental_Psychology_General	Developmental Psychology, Aged
C18740	Developmental_Psychology_General	Psychology	Developmental Psychology, General	The study of the psychological, physiological, and behavioral changes in an organism that occur from birth to old age.
C18741	Device_or_Instrument_Development	Technology	Device or Instrument Development
C18742	Diagnostic_or_Prognostic_Tests	Test|Test_Generic	Diagnostic or Prognostic Tests
C18743	Dietary_Epidemiology	Epidemiology	Dietary Epidemiology
C18744	Dietary_Factors	Epidemiological_Factors	Dietary Factors	Dietary Factors; the consideration of dietary factors as a variable in disease incident, transmission, and control.
C18745	Differentiation_and_Growth	Funding_Category	Differentiation and Growth	A funding category for studies concerned with cell growth or cell differentiation.
C18746	Directors_Working_Group	Professional_Organization_or_Group	Director's Working Group	Ad hoc "think tanks" appointed to address key scientific issues. Their members include leaders in laboratory, clinical, and population-based research drawn from the extramural and intramural research community, staff of the NIH and other government agencies, members of professional organizations, and interested consumers and patient advocates. Their recommendations provide a framework for Institute strategic planning and for the development of operational plans by NCI divisions. (National Cancer Institute-1999 Budget Request)
C18747	Discover_and_Develop_HIV_Treatments-Preclinical	AIDS_Treatment_Research	Discover and Develop HIV Treatments-Preclinical	Improve understanding of the structure and function of molecular targets in order to develop improved assays for such targets; conduct screening, discovery, and preclinical development of novel anti-HIV agents and strategies (such as gene transfer technology and interruption of transmission) directed to the virus and/or host cell; and foster industrial activity and collaborations.
C18748	Division_of_Cancer_Biology	Component_of_the_National_Cancer_Institute	Division of Cancer Biology|DCB	The Division of Cancer Biology (DCB) was created by the reorganization of NCI in 1995, and has the principal Federal responsibility for managing a grant- and contract-supported program of basic and applied research on cancer cell biology, including research on carcinogenesis and cancer immunology. In addition to investigating basic cellular mechanisms, this research includes examination of the role of biological, chemical, and physical agents in the initiation, promotion or inhibition of cancer and the biological and health effects of exposures to ionizing and non-ionizing radiation.
C18749	Division_of_Cancer_Epidemiology_and_Genetics	Component_of_the_National_Cancer_Institute	Division of Cancer Epidemiology and Genetics|DCEG	The Division of Cancer Epidemiology and Genetics (DCEG) is the primary focus within the National Cancer Institute for population based research on environmental and genetics determinants of cancer. Intramural and collaborative interdisciplinary studies are conducted on the distribution, causes, and natural history of cancer, and the means for its prevention. Research areas of special interest include genetic predisposition, lifestyle factors, environmental contaminants, occupational exposures, medications, radiation and infectious agents, as well as statistics and methods development.
C18750	Division_of_Cancer_Prevention	Component_of_the_National_Cancer_Institute	Division of Cancer Prevention|DCP	Reorganized on October 1, 1997 to the extramural Division of Cancer Prevention and the extramural Division of Cancer Control and Population Science.
C18751	Division_of_Cancer_Treatment_and_Diagnosis	Component_of_the_National_Cancer_Institute	Division of Cancer Treatment and Diagnosis|DCTD|Division of Cancer Treatment, Diagnosis and Center
C18752	Division_of_Clinical_Sciences	Component_of_the_Center_for_Cancer_Research	Division of Clinical Sciences	Merged with the Division of Basic Sciences in January, 2001 to form the Center for Cancer Research
C18753	Division_of_Extramural_Activities	Component_of_the_National_Cancer_Institute	Division of Extramural Activities
C18754	Radiation_Induced_DNA_Damage	Radiation-Induced_Abnormalities	Radiation Induced DNA Damage|DNA Damage, Radiation Induced|Genotoxicity, Radiation Induced|Radiation-Induced DNA Damage	Damage to DNA caused by ionizing radiation.  Can cause base change mutations or strand breakage.
C18755	DNA-Protein_Interaction	DNA_Binding	DNA-Protein Interaction	The biochemical and biophysical properties governing the binding of proteins to DNA
C18756	Dominant-Negative_Mutation	Gene_Mutation	Dominant-Negative Mutation|Dominant Negative|Dominant-Negative Mutant	A dominant-negative mutation produces a mutant gene product that can inhibit the function of the wild-type gene product in heterozygotes.
C18757	Drosophila_Patched_Gene	Non-Human_Gene	Drosophila Patched Gene	Drosophila Patched Gene (Patched Family) encodes Patched protein, an integral membrane protein containing an SSD domain that acts as a segmentation polarity pattern receptor for hedgehog during embryonic segmentation and during imaginal disk development. Patched associates with smoothened protein to transduce hedgehog signal, leading to activation of wingless, decapentaplegic, and patched. In the absence of hedgehog, patched represses constitutive smoothened signaling through fused. (NCI)
C18758	Epstein_Barr_Nuclear_Antigen-3	Viral_Protein	Epstein Barr Nuclear Antigen 3|EBNA3	Viral nuclear antigen expressed in latency
C18759	Egg_Preservation	Preservation_Technique	Egg Preservation	Methods for preserving egg cells such as oocyte cryopreservation in liquid nitrogen.
C18760	Embryo_Preservation	Preservation_Technique	Embryo Preservation	Methods for short term or long term preservation of embryos at the two cell stage or beyond.  Examples: short term storage in buffered media with serum at reduced temperature or long term cryopreservation in liquid nitrogen.
C18761	Endocrine_Epidemiology	Epidemiology	Endocrine Epidemiology
C18762	Enhancing_Accessibility_to_Health_Care	Business_Rules	Enhancing Accessibility to Health Care	Currently undefined.
C18763	Environmental_Engineering_Atmosphere	Environmental_Engineering	Environmental Engineering, Atmosphere
C18764	Environmental_Engineering_Land	Environmental_Engineering	Environmental Engineering, Land
C18765	Environmental_Engineering_Water	Environmental_Engineering	Environmental Engineering, Water
C18766	Environmental_Health_Sciences	Health_Sciences	Environmental Health Sciences
C18767	Environmental_Health_Sciences_Other	Environmental_Health_Sciences	Environmental Health Sciences, Other
C18768	Epidemiology_Age_Sex	Epidemiological_Factors	Epidemiology, Age, Sex	The consideration of age and sex as variables in disease incident, transmission, and control.
C18769	Environmental_Epidemiology	Environmental_Health_Sciences|Occupational_Environmental_Epidemiology	Environmental Epidemiology|Epidemiology, Environmental	Environmental epidemiology focuses on exposures that are external to the individual, including physical, chemical, biologic, soci-cultural and lifestyle factors that influence the risk of disease.
C18770	Epidemiology_Geographic_Location	Epidemiological_Factors	Epidemiology, Geographic Location	The consideration of geographic location as a variable in disease incident, transmission, and control.
C18771	Epidemiology_Occupation	Epidemiological_Factors	Epidemiology, Occupation	The consideration of occupation as a variable in disease incident, transmission, and control.
C18772	Personal_Medical_History	Personal_Attribute	Personal Medical History|HX|History|Medical History	A record of a patient's background regarding health and the occurrence of disease events of the individual.  In addition, personal medical history may be a variable in epidemiologic studies.
C18773	Epidemiology_Race_Ethnic_Origin	Epidemiological_Factors	Epidemiology, Race/Ethnic Origin	The consideration of race and/or ethnic origin as variables in disease incident, transmission, and control.
C18774	Epidemiology_Tobacco_Alcohol_Drugs	Epidemiological_Factors	Epidemiology, Tobacco, Alcohol, Drugs	The consideration of tobacco, alcohol, or drug use as variables in disease incident, transmission, and control.
C18775	Epithelial_Physiology	Physiology	Epithelial Physiology	The study of the mechanical, physical, and biochemical functions of epithelial cells and tissues.
C18776	Epithelial-Stromal_Communication	Intercellular_Communication	Epithelial-Stromal Communication|Epithelial-Stromal Interaction	The various effects, including growth, differentiation, and death, imposed on epithelial cells by the surrounding matrix and neighboring accessory cells. (NCI)
C18777	Exercise_Physiology_and_Stress	Physiology	Exercise Physiology and Stress	The field of research concerned with the interaction between exercise physiology and stress.
C18778	Expedite_Dissemination	Information_Dissemination	Expedite Dissemination	Support research to identify existing gaps in communications approaches, identify existing strategies that are effective, and develop and test new and innovative communication strategies that will improve access to and use of state-of-the-art HIV information by all relevant target audiences. (FMB)
C18779	Experimental_Models_Other	Retired_Concepts	Experimental Models, Other
C18780	Experimental_Ophthalmology	Ophthalmology	Experimental Ophthalmology
C18781	Experimental_Pathology_Other_Than_Tumors	Experimental_Pathology	Experimental Pathology, Other Than Tumors
C18782	Experimental_Pathology_Tumors	Experimental_Pathology	Experimental Pathology, Tumors	The study of the neoplastic process by studying artificially produced tumors.
C18783	Experimental_Psychology_Animal	Experimental_Psychology	Experimental Psychology, Animal	The use of animals to study psychological traits such as math reasoning or ability to learn.
C18784	Experimental_Psychology_Human	Experimental_Psychology	Experimental Psychology, Human
C18785	Experimental_Tumor	in_vitro_Model	Experimental Tumor	Laboratory tumor models used to study tumor development and treatment.
C18786	Extra-Nuclear_Genetics	Genetics	Extra-Nuclear Genetics	The genetics of extra-nuclear DNA, eg. Mitochondria and chloroplasts.
C18787	Extramural_Activities	Business_Rules	Extramural Activities|EXTMR|Extramural	Research activities which take place off the NIH campus.
C18788	Extramural_Epidemiology_and_Genetics_Program	Component_of_the_Division_of_Cancer_Control_and_Population_Sciences	Extramural Epidemiology and Genetics Program	The Extramural Epidemiology and Genetics Program is the extramural equivalent of the NCI Division of Cancer Epidemiology and Genetics.
C18789	Extramural_Policy_Announcements	Program_Announcements	Extramural Policy Announcements|Policy Announcements, Extramural
C18790	Family_Health_Nursing	Nursing	Family Health Nursing	General and comprehensive nursing practice directed to families.  Often involves home visits.
C18791	Family_Sociology	Sociology	Family Sociology
C18792	Fellowship_Programs_DCEG	Fellowship_Programs	Fellowship Programs, DCEG	The National Cancer Institute (NCI) offers training fellowships to individuals who are interested in careers in cancer epidemiology, biostatistics, or genetics.  DCEG supports two programs: One provides pre- and postdoctoral training in cancer epidemiology and biostatistics, and the other provides postdoctoral interdisciplinary training in cancer genetics and epidemiology. (from DCEG fellowship programs)
C18793	Fellowship_Programs_F-Series	Funding_Mechanisms	Fellowship Programs, F-Series	F31: Predoctoral Individual National Research Service Award, F32: NIH National Research Service Award for Individual Postdoctoral Fellows, F33: National Research Service Award--Senior Fellowships, F34: MARC NRSA Individual Post-doctoral Program Appointee, F35: Intramural NRSA Individual Postdoctoral Program Appointee, F36: MARC Visiting Scientists Fellowships (NIGMS) (from NIH Guide for Grants and Contracts Extramural Policy Notices)
C18794	Fiber_Chemistry	Chemistry	Fiber Chemistry
C18795	First_Independent_Research_Support_and_Transition_Awards	Award|Research_Project_Grants|Research_Support	First Independent Research Support and Transition Awards|FIRST Award|First Independent Research Support and Transition Awards (R29)|R29 Mechanism|R29 Program
C18796	Five-A-Day_Program	Patient_or_Public_Education	Five-A-Day Program|5-A-Day Program	The 5-A-Day message is "Eat 5 servings of fruits and vegetables a day for better health." (5-A-Day For Better Health, NIH Guide, Volume 21, Number 12, March 27, 1992)
C18797	Analytical_Centrifugation	Centrifugation	Analytical Centrifugation|Fractionation, Centrifugation, Analytical	A type of centrifugation technique equipped with photograph capability.  It allows you to determine the time it takes a particle to travel in the cell of the rotor under standard conditions while it is spinning.
C18798	Elutriative_Centrifugation	Centrifugation	Elutriative Centrifugation|Fractionation, Centrifugation, Elutriation	Separation of particles on the basis of their differential sedimentation rate. (On-line Medical Dictionary)
C18799	Preparative_Centrifugation	Centrifugation	Preparative Centrifugation|Fractionation, Centrifugation, Preparative	The type of centrifugation used to separate cell components.  Consists of two basic procedures: differential centrifugation and density gradient centrifugation (from http://www2.uca.edu/biology/johnc/FRACTION.htm)
C18800	Chemical_Fractionation	Biomolecule_Separations_Technology	Chemical Fractionation|Fractionation, Chemical	Methods of fractionation, isolation, and purification based on the physico-chemical properties of the substance, e.g. crystallization, distillation, solubility (miscibility).
C18801	Frederick_Cancer_Research_and_Development_Center	Intramural_Research_Program	Frederick Cancer Research and Development Center	A government-owned, contractor operated cancer research facility located in Frederick, MD.  Operated under the direction of the Division of Cancer Biology.
C18802	Gastrointestinal_Physiology	Physiology	Gastrointestinal Physiology	The science concerned with the normal processes of the stomach and intestines and how they are affected by drugs or disease.
C18803	Gene_Knock-Out_Model	Transgenic_Model	Gene Knock-Out Model	Models of human disease produced through gene knockout methods
C18804	Gene_Mapping_Human	Gene_Mapping	Gene Mapping, Human|DNA Sequencing, Gene Mapping, Human|DNA Sequencing, Human Gene Mapping	Determination of the relative positions of human genes on a DNA molecule (chromosome or plasmid) and of the distance, in linkage units or physical units, between them. (from On-line Medical Dictionary)
C18805	Gene_Mapping_Non-Human	Gene_Mapping	Gene Mapping, Non-Human|DNA Sequencing, Non-Human Gene Mapping	Determination of the relative positions of genes from human organisms on a DNA molecule (chromosome or plasmid) and of the distance, in linkage units or physical units, between them. (On-line Medical Dictionary)
C18806	Genetic_Medicine	Medicine	Genetic Medicine	NIH Emphasis Area -- In the realm of genetic medicine, the rapid progress of the Human Genome Project, a growing understanding of the genomes of other species, and new methods for the manipulation of genes are swiftly changing concepts of disease and possibilities for its control.  The real possibility of being able to identify the inherited mutations that contribute to cancer risk, developmental abnormalities, immunodeficiencies, and mental and neurological disease (such as epilepsy, stroke, autism, and sensory disorders) deserve significant new effort.
C18807	Genetic_Models_for_Cancer	Cancer_Model	Genetic Models for Cancer
C18808	Genetic_Risk	Risk	Genetic Risk	Risk of developing a disease based on a patients heredity
C18809	Genetic_Toxicology	Toxicology	Genetic Toxicology
C18810	Applied_Genetics	Genetics	Applied Genetics|Genetics, Applied
C18811	Experimental_Genetics	Genetics	Experimental Genetics
C18812	Genetics_Other	Genetics	Genetics, Other
C18813	Gerontological_Nursing	Nursing	Gerontological Nursing|Geriatric Nursing|Nursing of the Elderly	Nursing practices for older age individuals
C18814	Global_Change	Conceptual_Entities	Global Change
C18815	Global_Change_UV	Global_Change	Global Change/UV	An increase in global UV with the diminishing of the ozone layer
C18816	Glycobiology	Carbohydrate_Biochemistry	Glycobiology	Biochemistry of carbohydrates, aldehydic or ketonic derivative of polyhydric alcohols, the name being derived from the fact that the most common examples of such compounds have formulas that may be written Cn(H2O)n (e.g., glucose, C6(H2O)6; sucrose, C12(H2O)11), although they are not true hydrates and the name is in that sense a misnomer. The group includes compounds with relatively small molecules, such as the simple sThe study, at the molecular level, of the structural and functional roles of carbohydrate-containing structures and of the interactions of carbohydrates with other structures, especially proteins.
C18817	Grant_Opportunities_DCB	Extramural_Funding_Mechanisms	Grant Opportunities, DCB	The Division of Cancer Biology (DCB) supports a variety of investigator-initiated research grants from academic institutions, research institutes, and small businesses.  Two major types of grants are Program Announcements and Requests for Applications. (from DCB Grant Opportunities)
C18818	Grant_Referral_and_Review	Business_Rules	Grant Referral and Review
C18819	Grants_and_Contracts_Operations	Grants_and_Contracts_NIH	Grants and Contracts Operations
C18820	Grants_and_Contracts_NIH	Funding	Grants and Contracts, NIH|NIH, Grants and Contracts	Monetary awards made by NIH for research and support services.
C18821	Award_Guidelines	Document_Type	Award Guidelines|Grants, Guidelines and Descriptions
C18822	Grants_Preparing_Applications	Business_Rules	Grants, Preparing Applications
C18823	Group_Affiliation	Social_Concepts	Group Affiliation	Inclusion of an individual in a peer or minority group
C18824	Cell_Cycle_Inhibition	Cell_Cycle_Regulation	Cell Cycle Inhibition	Preventing the normal cycle of cellular growth and division.
C18825	Growth	Organismal_Process	Growth|Generalized Growth	Processes that promote either specific or nonspecific formation of additional tissue mass, typically by cell proliferation.
C18826	Gynecologic_Pathology	Pathology	Gynecologic Pathology	The medical science and specialty practice concerned with all aspects of disease of the genital tract, endocrine system, and reproductive system of the female.
C18827	Gynecological_Obstetrical_Nursing	Nursing	Gynecological/Obstetrical Nursing|OB/GYN Nursing	Nursing care of women, specifically with regard to childbearing and gynecological care.
C18828	Health_and_Behavior_Intramural_Dollars	Funding_Category	Health and Behavior Intramural Dollars
C18829	Health_and_Behavior_Training_Dollars	Funding_Category	Health and Behavior Training Dollars
C18830	Health_Promotion_and_Care	Health_Education	Health Promotion and Care	Promotion of the use of available health care resources and the adoption of more healthful lifestyles, and attempts to make resources available to underserved populations and to make these populations aware of the resource availability.
C18831	Health_Promotion_and_Care-Work_Site	Health_Promotion_and_Care	Health Promotion and Care-Work Site	Programs at the work site to promote health (e.g., anti-smoking).
C18832	Health_Promotion_in_Nursing	Preventive_Medicine	Health Promotion in Nursing
C18833	Health_Promotion_Sciences	Allied_Health_Sciences	Health Promotion Sciences
C18834	Herpes_Other_Than_Genital	Herpes_Total	Herpes, Other Than Genital|Herpes, Other Than Genital Virus	A funding category that should include all grants having to do with herpes research except those having to do with genital infection.
C18835	High_Percent_Effort	Business_Rules	High Percent Effort
C18836	High-LET_Radiation	Electromagnetic_Radiation	High-LET Radiation|High Linear Energy Transfer Radiation	Radioactive particles that deposit a high amount of energy by radiation per unit length of travel.
C18837	HIV_and_HIV_Genome	Funding_Category	HIV and HIV Genome	1A1; Basic Sciences Research (includes vaccine and chemotherapy development); Biomedical Research; HIV and HIV Genome (structure, function)
C18838	HIV_Surveys_Incidence_and_Prevalence	Questionnaire	HIV Surveys, Incidence and Prevalence	2A2; Risk Assessment and Prevention; Surveillance; HIV surveys (incidence and prevalence)
C18839	Host_Defense_Mechanism	Multicellular_Process	Host Defense Mechanism	Among the many Host Defense Mechanisms against pathology are physical barriers to pathogens, immediate nonspecific and constitutive (innate) defenses, specific inducible immune responses, metabolic and physiologic homeostatic mechanisms, detoxification mechanisms, repair processes, and healing mechanisms.
C18840	Howard_Temin_Award_Guidelines	Award_Guidelines	Howard Temin Award, Guidelines	This five year career development award provides a mechanism for bridging the transition from a mentored research environment to an independent research career for scientists who have demonstrated unusually high potential during their initial stages of training, career development and are focusing on human disease.
C18841	Human_Fetal_Tissue	Fetal_Tissue	Human Fetal Tissue	Any tissue from a human fetus.
C18842	Hybridization_Array	Diagnostic_Therapeutic_and_Research_Equipment	Hybridization Array	A molecular biology device that utilizes a set of defined oligonucleotide probes, recombinant clones, or other samples attached in a specific grid arrangement to a solid support for nucleic acid hybridization assays in gene mapping studies or in determining gene sequences, sequence variations, or gene expression patterns.
C18843	Imaging_Technology	Technology	Imaging Technology|Imaging|Imaging Technologies	Any of a number of technologies that permits the visualization and acquisition of images into a physical or electronic record.
C18844	Immune_Reconstitution_Approaches_for_HIV	AIDS_Treatment_Research	Immune Reconstitution Approaches for HIV	Develop and evaluate strategies that will enhance, restore, and/or maintain the immune systems of HIV-infected individuals and extend our understanding of immunopathogenesis.
C18845	Immunologic_Epidemiology	Epidemiology	Immunologic Epidemiology
C18846	Immunotoxicology	Toxicology	Immunotoxicology
C18847	Improve_Access	Business_Rules	Improve Access	Support the effective dissemination, communication, and utilization of HIV/AIDS information to all constituent communities of the NIH.
C18848	Independent_Scientist_Award_Guidelines	Award_Guidelines	Independent Scientist Award, Guidelines
C18849	Individual_Cancer_History	Personal_Medical_History	Individual Cancer History	A record of a patient's medical background regarding the occurrence of cancer and cancer-related problems. (NCI)
C18850	Non-AIDS_Infant_Mortality	Infant_Mortality	Infant Mortality, Non-AIDS	infant death due to causes other than AIDS
C18851	Infectious_Disease_Epidemiology	Epidemiology	Infectious Disease Epidemiology|Infectious Epidemiology	Epidemiology as it relates to infectious diseases.
C18852	Infrastructure_Domestic_and_International	Research_Infrastructure	Infrastructure Domestic and International	Establish appropriate infrastructure for the conduct of HIV research domestically and internationally.
C18853	Inhalation_Toxicology	Toxicology	Inhalation Toxicology
C18854	Institutional_National_Research_Service_Award	National_Research_Service_Awards|Training_Programs_T-Series	Institutional National Research Service Award|Institutional Award|T32 Mechanism|T32 Program	National Research Service Award (NRSA) institutional training grants (T32) enable eligible institutions to develop or enhance predoctoral and postdoctoral research training opportunities for individuals, selected by the institution, who are training for careers in specified shortage areas of biomedical and behavioral research. The purpose of the NRSA program is to help ensure that highly trained scientists are available in adequate numbers and in the appropriate research areas and fields to carry out the nation's biomedical and behavioral research agenda. (National Research Service Award Institutional Research Training Grants, NIH Guide, Volume 23, Number 21, June 3, 1994)
C18855	DNA_Integration	DNA_Sequence_Rearrangement	DNA Integration|Integration	In molecular biology, a recombination event in which a genetic element is inserted.
C18856	Intramural_Research_Training_Award	Intramural_Research_Award	Intramural Research Training Award|IRTA	The Postdoctoral Intramural Research Awards Program provides new investigators with advanced training and an opportunity to conduct full-time research in a laboratory environment that is compatible with the interests of the participant.  IRTA Traineeships are established for the principle benefit of the participant and to provide opportunities for developmental training and practical research experience in a variety of disciplines related to biomedical research, medical library research and related fields.
C18857	Intramural_Research_Program	Component_of_the_National_Cancer_Institute	Intramural Research Program|Intramural Program	The office that oversees research efforts which take place on the NIH campus.
C18858	Invertebrate_Biology	Zoology	Invertebrate Biology	The science concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals that have no spinal column.
C18859	Invertebrate_Tissue_and_Cells	Specimen	Invertebrate Tissue and Cells|Invertebrate Tissue, Cells	Tissue and cells from the general category of the kingdom Animalia (multicellular animals) including those phyla whose members lack a notochord.
C18860	Laboratory_Animal_Medicine	Veterinary_Medicine	Laboratory Animal Medicine
C18861	Lipid_Biochemistry	Biochemistry	Lipid Biochemistry	The study of the biochemistry of lipids, including enzyme action.
C18862	Lipid_Chemistry	Organic_Chemistry	Lipid Chemistry	The 'test tube' chemical reactions of lipids-not involving enzymes
C18863	LMP1	Viral_Protein	LMP1	EBV latent membrane protein (NCI)
C18864	Low_Prevalence	Prevalence	Low Prevalence	4B2; Clinical Health Services Research And Delivery; Health Services Grants; Low Prevalence
C18865	Lymphocyte_Biology	Cellular_Immunology	Lymphocyte Biology	The structure and biological function of lymphocytes in the body.
C18866	Macrophage_Cell_Biology	Cellular_Immunology	Macrophage Cell Biology	The structure and biological function of macrophages
C18867	Mathematical_Biology	Theoretical_Biology	Mathematical Biology	Interdisciplinary field of study in which theoretical, computational, or mathematical research is applied to or motivated by biology.
C18868	Medical_Entomology	Entomology	Medical Entomology	The study of insects as they relate to human disease.
C18869	Medical_Imaging_Virtual_Reality	Medical_Imaging	Medical Imaging, Virtual Reality	Virtual reality in Medical Imaging is the technique of combining 3D DICOM image data sets produced by medical imaging equipment with extremely high-powered computer capabilities. Virtual reality employs medical images as a foundation to create innovative methods of reviewing and analyzing the data they produce. (NCI2005)
C18870	Medical_Radiation_Physics	Nuclear_Medicine	Medical Radiation Physics
C18871	Medicine_Precancer	Funding_Category	Medicine, Precancer	Medicine applied to diseases that predispose to cancer.
C18872	Mentored_Clinical_Scientist_Development_Award	Clinical_Investigator_Award	Mentored Clinical Scientist Development Award (K08)|Mentored Clinical Scientists Development Award|Phased Career Development	To provide the opportunity for promising medical scientists with demonstrated aptitude to develop into independent investigators, or for faculty members to pursue research aspects of categorical areas applicable to the awarding unit, and aid in filling the academic faculty gap in these shortage areas within health professions institutions of the country.
C18873	Microbial_Physiology	Microbiology	Microbial Physiology	The metabolism of microbial life forms.
C18874	Medical_Microbiology	Microbiology	Medical Microbiology|Microbiology, Medical	The study of microorganisms with an emphasis on their role in the human disease process.
C18875	Microbiology_Other	Microbiology	Microbiology, Other
C18876	Microscopy_Electron_Other	Electron_Microscopy	Microscopy, Electron, Other
C18877	Microscopy_Light_Other	Light_Microscopy	Microscopy, Light, Other
C18878	Quantitative_Microscopy	Light_Microscopy	Quantitative Microscopy|Microscopy, Quantitative	A microscopy technique comprised of light microscopy coupled with modern microscope optics and use of algorithms for the restoration, segmentation, and analysis of digital images for the quantitative analysis of specimens in order to achieve the accurate measurement of "analog" quantities of a digital representation of an image. (NCI2005)
C18879	Minority_Health_and_Assistance_Targeted	Funding_Category	Minority Health and Assistance, Targeted	Health aid that is directed to minority groups.
C18880	Modeling_of_Functional_Interactions	Computer_Modeling	Modeling of Functional Interactions	Using mathematical methods to simulate processes to predict the interaction of proteins at the functional level. (NCI2005)
C18881	Nucleic_Acid_Sequencing	DNA_Analysis	Nucleic Acid Sequencing|Molecular Biology, Nucleic Acid Sequencing	The process of determining the sequence of purines and pyrimidines in nucleic acids and polynucleotides.
C18882	Molecular_Biology_Other	Molecular_Biology	Molecular Biology, Other
C18883	Protein_Sequencing	Protein_Analysis	Protein Sequencing|Molecular Biology, Protein Sequencing	The process of determining the sequence of amino acids within a protein molecule.
C18884	Molecular_Cytogenetics	Cytogenetics	Molecular Cytogenetics	Studies of chromosome biology and behavior at the molecular level.
C18885	Molecular_Medicine	Medicine	Molecular Medicine
C18886	Molecular_Receptor_Pharmacology	Biochemical_Pharmacology	Molecular Receptor Pharmacology
C18887	Molecular_Virology	Virology	Molecular Virology	The study of viral processes at the molecular level.  Includes infection, replication, and expression of the viral genome.
C18888	mRNA_Expression	Gene_Expression_Process	mRNA Expression	The synthesis or transcription of messenger RNA.
C18889	Muscle_Physiology_Contractile	Physiology	Muscle Physiology, Contractile	The physiology of muscle contraction
C18890	Mutation_Detection	Molecular_Biology_Techniques	Mutation Detection	The detection by physical, chemical, or biological means of an altered DNA sequence. Includes SSCP, DNA sequencing, hybridization, and reporter gene expression.
C18891	Mutation_Spectra	Mutation_Analysis	Mutation Spectra	The range of mutations that have occurred to a gene, or at a specific locus.
C18892	Mycology_Nonclinical	Microbiology	Mycology, Nonclinical	The study of fungus in a nonclinical environment, ie not as a pathogen
C18893	National_Cancer_Program	Professional_Organization_or_Group	National Cancer Program|NCP	Plans and coordinates the national cancer research program, encompassing the programs of the National Cancer Institute, related programs of the other research institutes, and other Federal and non-Federal programs.
C18894	National_Cancer_Advisory_Board	NCI_Advisory_Boards_and_Groups	National Cancer Advisory Board|NCAB	Advise the Secretary, Department of Health and Human Services and the Director, NCI, with respect to the activities of the Institute including reviewing and recommending for support grants and cooperative agreements, following technical and scientific peer review.
C18895	NCI_Program_T_P_or_N	Extramural_Funding_Mechanisms	NCI Program (T, P, or N)	T-Series: Training Programs, P-Series: Research Program Projects and Centers, N-Series: Research Contracts
C18896	Strategic_Planning	Business_Rules	Strategic Planning
C18897	Neurofibromatosis_Related	Retired_Concepts	Neurofibromatosis, Related
C18898	Neurogenetics	Genetics	Neurogenetics	A subdiscipline of genetics with a focus on nerve cells and the nervous system.
C18899	Neurovirology	Neurosciences|Virology	Neurovirology	Study of viruses which infect nerves.
C18900	Individual_National_Research_Service_Award	National_Research_Service_Awards	Individual National Research Service Award|NIH National Research Service Award for Individual	National Research Service Awards (NRSA) are made to individual fellowship applicants selected for award as a result of national competition for research training in specified health-related areas.  The National Institutes of Health (NIH) awards NRSA individual postdoctoral fellowships (F32) to the most promising applicants to support full-time research training related to the mission of the NIH awarding components. Some specialized individual predoctoral fellowships (F31s and F30s) and Senior  Fellowships (F33s) are also provided under the NRSA. (NRSA Guide: Sections I and II)
C18901	Request_for_Applications	Funding_Opportunities	Request for Applications|NIH RFA|RFA	A formal statement that invites grant or cooperative agreement applications in a well-defined scientific area to accomplish specific program objectives. The RFA indicates the estimated amount of funds set aside for the competition, the estimated number of awards to be made, and the application receipt date(s).
C18902	None_or_Not_Applicable	Business_Rules	None or Not Applicable|N/A|Not Applicable
C18903	Nucleic_Acid_Biochemistry_Synthesis	Nucleic_Acid_Biochemistry	Nucleic Acid Biochemistry, Synthesis	Research into natural and artificial means for synthesis of nucleic acids.
C18904	Nutrition_Training_Dollars	Funding_Category	Nutrition: Training Dollars
C18905	Occupational_Carcinogenesis	Environmental_Carcinogenesis	Occupational Carcinogenesis	Studies of carcinogens encountered through occupational exposure. The carcinogens can be of any type: chemicals, electromagnetic fields, UV, viruses, etc. Many of these agents may also be commonly encountered outside the occupational environment (e.g., UV) but in such cases they are not coded in this category; for farmers and sailors, UV is an occupational carcinogen. Epidemiologic studies will usually clearly identify occupational carcinogens but in experimental studies or analyses of carcinogenic mechanisms, a judgment must be made as to whether the primary means of exposure is occupational and thus requires selection of SIC 28; for example, one could be exposed to benzene in various settings, but the most frequent exposure risk would be occupational. For chemicals with which you are unfamiliar, consult the Merck Index to determine whether the chemical is used in manufacturing, agriculture, or other occupational setting.
C18906	Occupational_Epidemiology	Occupational_Environmental_Epidemiology	Occupational Epidemiology
C18907	Ocular_Pathology	Pathology	Ocular Pathology	Subdiscipline of pathology with a focus on vision and the eye.
C18908	Older_Population	Population_Group	Older Population|Older Populations	The population of retired people, generally over 62
C18909	Oncogene_Activation	Gene_Mutation	Oncogene Activation	Oncogene Activation involves a permanent and heritable nucleotide sequence change that alters proto-oncogene function and predisposes or promotes neoplastic cellular transformation.
C18910	Oncogene_E1A-E1B	Retired_Concepts	Oncogene E1A/E1B
C18911	Oncology_Other	Oncology	Oncology, Other
C18912	Optical_Methods	Physical_Chemical_Techniques	Optical Methods	Any method of quantitative or qualitative analysis that involves optics and/or the measurement of light.
C18913	Oral_Microbiology	Microbiology	Oral Microbiology	A microbiology subdiscipline concerned with microorganisms of the buccal cavity.
C18914	Organometallic_Chemistry	Organic_Chemistry	Organometallic Chemistry	The chemistry of organometallic compounds (compounds having bonds between one or more metal atoms and one or more carbon atoms of an organyl group).  This concerns the synthesis, structure, reactivity, and the properties of such compounds, and the chemical transformations they undergo.
C18915	Other_Minority	Minority_Group	Other Minority|Other Minorities	Other minorities not listed
C18916	Other_Multiple_Areas	Multiple_Anatomic_Sites	Other Multiple Areas	Used when the correct precoordinated combinations of areas is not listed.
C18917	Other_Support_Update	Business_Rules	Other Support Update
C18918	Other_Types_of_Training	Training	Other Types of Training	Other types of training not listed
C18919	Outcomes_of_Therapy	Outcome	Outcomes of Therapy	The results for various forms of therapy for a given disease
C18920	Outreach_Research	Research_Funding_Categories	Outreach Research	[Editor_Note:] part of Population Studies
C18921	Oxidative_Regulation	Metabolic_Control	Oxidative Regulation	Oxidative Regulation involves cellular and biochemical mechanisms that localize and control oxidation/reduction reactions, or that constrain their byproducts, in order to maintain cellular health and homeostasis.
C18922	Program_Research_Project_Grants	Research_Program_Projects_and_Centers_P-Series	Program Research Project Grants|P01 Mechanism|P01 Program|Program Project Grant|Research Program Projects	The program project grant is an institutional award made in the name of a program director for the support of a broadly based, long-term, multidisciplinary research program that has a well-defined central theme, research focus, or objective. The grant funds at least three interrelated projects and, often, core resources that support at least three projects at all times. Interrelationships and synergism among component research projects should result in greater scientific contributions than if each project were supported through a separate mechanism. The grant is based on the concept that projects closely related to a central theme can be conducted more effectively and efficiently through a coordinated, collaborative, multidisciplinary approach.
C18923	Pathogenesis_of_HIV_Malignancy	Viral_Pathogenesis	Pathogenesis of HIV Malignancy	Induction or development of a malignant disease(s) or condition(s) that results from retroviral activity or arises due to the immunocompromised state of an HIV infected individual. (NCI)
C18924	Pathogenesis_of_HIV_Neurological_Disease	Viral_Pathogenesis	Pathogenesis of HIV Neurological Disease	Elucidate the pathogenic mechanisms involved in HIV-associated neurological diseases and neurobehavioral dysfunction. Enhance a bidirectional flow between basic and clinical observations and intervention programs on HIV-related complications and foster interdisciplinary collaborations.
C18925	Pathogenesis_of_HIV_Opportunistic_Infection	Pathogenesis	Pathogenesis of HIV Opportunistic Infection	Induction or development of microbe-induced disease(s) in an immunocompromised HIV infected individual.  (NCI)
C18926	Pathogenesis_of_HIV-Related_Organ_Tissue_Disorder	Viral_Pathogenesis	Pathogenesis of HIV-Related Organ/Tissue Disorder	Induction or development of an organ or tissue disorder(s) that results from retroviral activity or arises due to the immunocompromised state of an HIV infected individual. (NCI)
C18927	Pathology_of_Tumors_in_Animals	Pathology	Pathology of Tumors in Animals
C18928	Insurance_and_Payment_Issues	Medical_Economics	Insurance and Payment Issues|Payment / Reimbursement Issues	The effect of insurance coverage on medical care and practices.
C18929	Pediatric_Adolescence_Nursing	Nursing	Pediatric/Adolescence Nursing	Nursing the ill pediatric and adolescent patient
C18930	Peptide_MHC_Complex	Immunoprotein	Peptide/MHC Complex|Peptide-MHC|Peptide-Major Histocompatibility Protein Complex|pMHC	Peptide MHC Complexes consist of proteolytically-processed low molecular weight amino acid fragments of antigenic foreign proteins noncovalently bound to self MHC antigens and displayed on the surface of antigen presenting macrophages to helper T cells as an important part of an immune response.
C18932	Perinatal_Epidemiology	Epidemiology	Perinatal Epidemiology
C18933	Peroxisome_Proliferation	Cellular_Stress_Response	Peroxisome Proliferation	Associated with hepatocellular carcinomas, Peroxisome Proliferation occurs in epigenetic "non-genotoxic" responses of hepatocytes to diverse peroxisome proliferator chemicals and involves, probably by a steroid superfamily receptor-based mechanism (PPARs), altered expression of cellular growth and/or differentiation genes, induction of peroxisomal enzymes, and possibly oxidative stress.
C18934	Pesticide_Toxicology	Toxicology	Pesticide Toxicology	The toxicology of pesticides
C18935	Phage_Display	Expression_Technologies_for_DNA_and_RNA	Phage Display	Molecular biology technique that facilitates cloning or identification of specific proteins or peptides with a specific antigenic, ligand or protein-binding, enzymatic, or other biological property.  It is based on the cloning of DNA within a phage coat protein gene so that the resulting protein is expressed as a fusion expressed on the surface of the phage.
C18936	Pharmacology_Biologicals	Pharmacology	Pharmacology, Biologicals	The pharmacology of biologics.
C18937	Pharmacology-Drug_Structure	Biochemical_Pharmacology	Pharmacology-Drug Structure	The relation of a drug structure to its activity.
C18938	Photometry_Spectrum_Analysis_Visible_Light	Spectroscopy	Photometry/Spectrum Analysis, Visible Light	Analysis of the absorption or transmittance of light in the visible region of the electromagnetic spectrum by a specific compound.  By itself, this technique does not lead to the identification of a substance, but analysis of the spectrum (absorption versus wavelength) can help identify the presence of specific chromophores in the molecule.  When the identity of the compound is known, determination of the absorbance at a specific wavelength yields quantitative information about the material analyzed.
C18939	Photometry_Spectrum_Analysis_X-ray_Neutron	Spectroscopy	Photometry/Spectrum Analysis, X-ray/Neutron
C18940	Phylogenetic_Analysis	Genetic_Techniques	Phylogenetic Analysis|Phylogenetics	Phylogenetic analysis is the study of evolutionary relationships among the many different kinds of life on earth, both living (extant) and dead (extinct). It includes creating evolutionary trees using computer programs.
C18941	Electromagnetic_Flux	Physical_Phenomena_or_Properties	Electromagnetic Flux|Physical Agents, Electromagnetic Flux	Changing current and concomitantly magnetic fields
C18942	Phospholipase-C_Gamma-2	Phospholipase	Phospholipase C Gamma 2|1-Phosphatidylinositol Phosphodiesterase|1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Gamma 2|EC 3.1.4.11|PI-Specific PLC Gamma|PLC-Gamma-2|PLC-IV|PLCG2|Phosphatidylinositol-Specific Phospholipase C-Gamma|Phosphoinositide Phospholipase C|Phospholipase C, Gamma 2 (Phosphatidylyinositol-specific)|Phospholipase C-Gamma-2	Encoded by human PLCG2 Gene, 1265-aa 148-kDa Phospholipase C Gamma 2 is a crucial enzyme that generates DAG and IP3 second messengers in the transmembrane signaling of ligand-activated growth factor receptors. Containing a PI-PLC X-box catalytic domain, a PI-PLC Y-box catalytic domain, a C2 domain, a PH domain, 2 SH2 domains, and an SH3 domain, PLCG2 phospholipase activity increases upon phosphorylation on tyrosine residues following activation of growth factor and immune system receptors. (NCI)
C18943	Planning_Evaluation_and_Analysis	Business_Rules	Planning, Evaluation and Analysis
C18944	Plant_Sources	Business_Rules	Plant Sources
C18945	Plant_Tissue_Cells	Specimen	Plant Tissue, Cells	Tissue and cells derived from plants
C18946	Policy_Notice_NIH	Document_Type	Policy Notice, NIH
C18947	RNA_Polyadenylation	Polymerization	RNA Polyadenylation|Polyadenylation	1. The process of formation of poly(adenylic acid). 2. The covalent modification of a macromolecule (e.g., mRNA) by the formation of a polyadenylyl moiety covalently linked to the macromolecule.
C18948	Polymer_Chemistry	Organic_Chemistry	Polymer Chemistry	The study of synthesis and application of polymers.  Polymers are any of numerous natural and synthetic compounds of usually high molecular weight consisting of up to millions of repeated linked units, each a relatively light and simple molecule.
C18949	Population_Analysis	Statistical_Methods	Population Analysis	Investigation of the component parts of a whole and the relationship between the parts, frequently using statistical methods, of a defined set of individuals or items (population). (NCI2005)
C18950	Population_Psychology	Psychology	Population Psychology
C18951	Post_Translational_Modification_Analysis	Protein_Analysis	Post Translational Modification Analysis	Techniques used for the analysis of the processing events of a protein after its translation from messenger RNA in order to gain insight into biological function. These include mass spectrometric peptide sequencing and analysis technologies. (NCI2005)
C18952	Post-Transcriptional_Regulation	Gene_Regulation	Post-Transcriptional Regulation|Post-Transcriptional Control|Post-Transcriptional Regulation Process	Any subcellular or molecular event, process, or condition that regulates the processing of a gene transcription product.
C18953	Pre-Clinical_Model	Model_System	Pre-Clinical Model|Preclinical Models	Theoretical models before being tested clinically
C18954	Prediction_of_Response_to_Therapy	Prognosis	Prediction of Response to Therapy
C18955	Predoctoral_Fellowship-Minority_Students	Predoctoral_Individual_National_Research_Service_Award	Predoctoral Fellowship--Minority Students|NRSA Predoctoral Fellowship Minority Students (F31)	These fellowships will provide up to five years of support for research training leading to the Ph.D., or equivalent research degree; the combined M.D./Ph.D. degree; or other combined professional doctorate/research Ph.D. degrees in the biomedical or behavioral sciences.  These fellowships are for well-qualified students from minority groups found to be underrepresented in the biomedical and behavioral sciences in the United States. (Predoctoral  Fellowship Awards For Minority Students, NIH Guide, Volume 24, Number 5, February 10, 1995)
C18956	Predoctoral_Fellowship-Students_with_Disabilities	Predoctoral_Individual_National_Research_Service_Award	Predoctoral Fellowship--Students with Disabilities|NRSA Predoctoral Fellowship Students w/Disabilities (F31)	The intent of this Predoctoral Fellowship Program is to encourage students with disabilities to seek graduate degrees and thus further the goal of increasing the number of scientists with disabilities who are prepared to pursue careers in biomedical and behavioral research.  These fellowships will provide up to five years of support for research training leading to the Ph.D. or equivalent research degree; the combined M.D./Ph.D. degree; or other combined professional doctorate/research Ph.D. degrees in the biomedical or behavioral sciences. (Predoctoral  Fellowship Awards For Students With Disabilities, NIH Guide, Volume 24, Number 5, February 10, 1995)
C18957	Preparation_for_Vaccine_Efficacy_Trials	Funding_Category	Preparation for Vaccine Efficacy Trials	Identify appropriate domestic and international populations and develop infrastructure and collaborations with government, communities, and industry necessary for ensuring adequate performance of efficacy trials.
C18958	Prevention_Capacity_Enhancement	Funding_Category	Prevention Capacity Enhancement
C18959	Prognostic_Factor	Diagnostic_or_Prognostic_Factor	Prognostic Factor|General Prognostic Factor|Prognostic/Survival Factor|prognostic factor	(prog-NOS-tik) A situation or condition, or a characteristic of a patient, that can be used to estimate the chance of recovery from a disease or the chance of the disease recurring (coming back).
C18960	Progress_Review_Group	NCI_Advisory_Boards_and_Groups	Progress Review Group	These groups are composed of scientists, health professionals, industry representatives and lay advocates brought together to assess the state of our knowledge and identify scientific opportunity and need in such high priority areas of research as prostate cancer and breast cancer. NCI will use the Groups' recommendations to help set a national research agenda in these areas. (National Cancer Institute-Justification of Estimates for Appropriations Committees)
C18961	Prostaglandin_Pharmacology	Pharmacology_Biologicals	Prostaglandin Pharmacology
C18962	Protein_Analysis	Molecular_Biology_Techniques	Protein Analysis	Analysis of protein components in a sample.  The most basic analysis involves determination of the mass or concentration of protein by any of a number of quantitative assays.  Increased level of detail in the analysis requires resolution of a mixture into its component proteins.  The characterization of a pure protein includes the determination of a number of its properties, among these, the molecular weight, isoelectric point, subunit composition, tryptic map, amino acid composition, amino acid sequence, hydrodynamics (s value, frictional coefficient, shape, aggregation state), thermodynamics (melting, folding, protein-protein interactions), and atomic structure (NMR, diffraction).
C18963	Protein-Carbohydrate_Interaction	Molecular_Interaction	Protein-Carbohydrate Interaction	Protein-Carbohydrate Interaction is a molecular interaction between protein and carbohydrate molecules.
C18964	Protein_Chemistry	Protein_Biochemistry	Protein Chemistry|Peptide/Protein Chemistry	The chemistry (synthesis, degradation, and modification) of proteins and peptides.
C18965	Protein_Disruption_Model	Experimental_Model	Protein Disruption Model
C18966	Protein_Expression	Gene_Expression_Process	Protein Expression	Protein Expression is the biosynthesis of new (often sets of distinct, functionally related) protein products, usually involving new mRNA transcripts, typically in response to an activating stimulus.
C18967	Protein_Function	Protein_Biochemistry	Protein Function	The action of enzymes, regulators, chaperones etc.
C18968	Protein_Hormone_Receptor	Cell_Surface_Receptor	Protein Hormone Receptor	Typically associated with the cell membrane, Protein Hormone Receptors selectively bind with high affinity to genetically-encoded polymerized amino acids in peptide linkage that have regulatory effects on the activity of specific target cells. A ligand-induced conformational and functional change in the receptor alters its interaction with target molecules, leading to changes in cellular physiology through modification of the activity of signal transduction pathways.
C18969	Protein_Import	Transmembrane_Transport	Protein Import	Protein Import involves active cellular mechanisms that directly promote the transport of a protein across the plasma membrane into a cell.
C18970	Protein_Kinase_Protein_Phosphorylation	Protein_Phosphorylation	Protein Kinase Protein Phosphorylation	Protein Kinase Protein Phosphorylation involves covalent linkage of a phosphate group (from a donor compound such as ATP) with a serine, threonine, or tyrosine residue of a Protein Kinase acceptor, often as a mechanism of kinase activity regulation.
C18971	Protein_Secretion	Cellular_Secretion	Protein Secretion	Vectorial transport of proteins across a cell membrane to the extracellular environment.
C18972	Protein_Amino_Acid_Biochemistry_Degradation_and_Protease_Chemistry	Protein_Biochemistry	Protein/Amino Acid Biochemistry, Degradation and Protease Chemistry
C18973	Protein_Amino_Acid_Biochemistry_Enzymology	Protein_Biochemistry	Protein/Amino Acid Biochemistry, Enzymology	The enzymes involved in the metabolism of proteins and amino acids.
C18974	Protein_Amino_Acid_Biochemistry_Synthesis	Protein_Biochemistry	Protein/Amino Acid Biochemistry, Synthesis	Protein synthesis occurs in the cell by translating the sequential codons in messenger RNAs into amino acid residues of a peptide chain.  This translation physically occurs in macromolecular complexes called ribosomes, pairing amino acid-carrying transfer RNA complexes with individual codons of the messenger RNA, transferring the elongating peptide to this tRNA-amino acid complex with formation of a peptide bond, releasing the previous tRNA, and translocating the messenger RNA to make the next codon available for pairing.  The process is then repeated until a termination codon is read and the peptide is released.
C18975	Public_Health_Education	Patient_or_Public_Education	Public Health Education	Health education aimed at the general public
C18976	Pulmonary_Pharmacology_Toxicology	Pharmacology	Pulmonary Pharmacology/Toxicology
C18977	PUR_Alpha_Protein	DNA_Binding_Protein	PUR Alpha|PURA|Purine-Rich Element Binding Protein A|Transcription Factor PUR1	PURA is a potent transactivator able to bind purine-rich DNA sequences (GAGA boxes), often found upstream of gene transcription start sites.  PURA is implicated in transcriptional control of many cellular genes, including MBP, FE65, and neuronal ACHR, as well as viral promoters for JCV and HIV-1.  PURA is also involved in cell growth control and interacts with hypophosphorylated RB1.  It interacts with large T-antigen and cellular protein YB-1 to activate JC viral DNA transcription.  PURA is also a single-stranded DNA-binding protein with specific affinity for a (GGN)n element present in several eukaryotic DNA replication initiation zones.
C18978	Radiation_Biology_Electromagnetic_Fields	Radiation_Biology	Radiation Biology, Electromagnetic Fields
C18979	Radiation_Biology_Low_Level_Ionizing_Radiation	Radiation_Biology	Radiation Biology, Low Level Ionizing Radiation
C18980	Radiation_Ionizing_Diagnostic_Imaging	Diagnostic_Imaging	Radiation Ionizing, Diagnostic Imaging	A technique for medical imaging that uses ionizing radiation like X-rays and gamma rays. Both x-rays and gamma rays are high energy, short wavelength electromagnetic radiation that are capable of penetrating and passing through most tissues. The technique is highly useful to determine the presence or absence of a specific medical condition. (NCI2005)
C18981	Radiation_Non-Ionizing_Diagnostic_Imaging	Diagnostic_Imaging	Radiation Non-Ionizing, Diagnostic Imaging	The use of non-ionizing radiation such as X-rays to obtain internal images of the body
C18982	Charged_Particles_Radiation	Ionizing_Radiation	Radiation, Charged Particles	A particle which carries a positive or negative electrical charge, typically an ionized atom or molecule, or an electron.
C18983	Low-Level_Ionizing_Radiation	Ionizing_Radiation|Low-Level_Radiation	Low-Level Ionizing Radiation|LLIR|Radiation Ionizing, Low Level|Radiation, Low-Level Ionizing
C18984	Non-Ionizing_Radiation_DX_or_RX	Radiation_Therapy	Radiation, Non-Ionizing DX or RX	Diagnostic or therapeutic use of non-ionizing radiation
C18985	Radioimmune_Chemistry	Immunochemistry	Radioimmune Chemistry
C18986	Radiology_Bone	Radiology	Radiology, Bone	A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease of the bone.
C18987	Radiology_Dental	Radiology	Radiology, Dental
C18988	Radiology_Head_Neck	Radiology	Radiology, Head, Neck	A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease of the head and neck.
C18989	Radiology_Soft_Tissue	Radiology	Radiology, Soft Tissue	A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease of soft tissue.
C18990	Radiology_Thorax_Chest	Radiology	Radiology, Thorax, Chest	A specialty concerned with the use of x-ray and other forms of radiant energy in the diagnosis and treatment of disease of the thorax and chest.
C18991	Receptor_Biology_and_Gene_Expression	Molecular_Biology	Receptor Biology and Gene Expression	The study of the regulation of gene expression by nuclear receptors.  Includes the mechanisms by which receptors are themselves regulated.
C18992	Receptor_Signaling	Cell_Signaling_Process	Receptor Signaling	Transduction of regulatory signals mediated by nuclear or cytoplasmic receptors.
C18993	Recombinant_Antibody	Recombinant_Protein	Recombinant Antibody|Recombinant Antibodies	Antibodies produced by recombinant DNA techniques.
C18994	Reduction_of_Opportunistic_Illness	AIDS_Treatment_Research	Reduction of Opportunistic Illness	Undertake epidemiologic research to reduce or prevent the occurrence of OIs in HIV-infected persons.
C18995	Regulatory_Affairs	Business_Rules	Regulatory Affairs	The business of a regulatory agency
C18996	Renal_Pharmacology	Pharmacology	Renal Pharmacology	The science concerned with drugs and their actions and uses in kidney biology and the treatment of kidney disease.
C18997	Renal_Urogenital_Pathology	Pathology	Renal/Urogenital Pathology	The medical science, and specialty practice, concerned with all aspects of disease of the kidney and general organs of reproduction and urination, but with special reference to the essential nature, causes, and development of abnormal conditions, as well as the structural and functional changes that result from the disease processes.
C18998	Repair_Enzymology	Nucleic_Acid_Biochemistry_Enzymology	Repair Enzymology|DNA Repair Enzymology	The study of the enzymes and mechanisms involved in the repair of damaged DNA.
C18999	Reproduction_Other	Retired_Concepts	Reproduction, Other
C19000	Reproductive_Biology	Developmental_Biology	Reproductive Biology
C19001	Reproductive_Endocrinology	Endocrinology	Reproductive Endocrinology	The study of those hormones, and their actions, which affect fertility and pregnancy.
C19002	Reproductive_Physiology	Physiology	Reproductive Physiology	The science concerned with the normal processes of organismal reproduction.
C19003	Research_Construction_Programs_C-Series	Funding_Mechanisms	Research Construction Programs, C-Series	To provide matching federal funds, up to 75%, for construction or major remodeling, to create new research facilities. In addition to basic research laboratories this may include, under certain circumstances, animal facilities and/or limited clinical facilities where they are an integral part of an overall research effort (C06). (from Grant Guidelines and Descriptions, NCI)
C19004	Research_Contracts	Grants_and_Contracts_NIH|Research_Support	Research Contracts	A research contract differs from a grant or cooperative agreement awarded in response to an RFA with regard to the rules that govern them. Contracts must comply with the provisions of the U.S. Government's Federal Acquisition Regulations {FAR}. The FAR includes the forms and procedures used in the solicitation for and award of contracts, and identifies the level of Government oversight of performance.
C19005	Research_Methods	Research_Funding_Categories	Research Methods	Develop and evaluate new laboratory assays, behavioral methods, and statistical techniques for epidemiologic studies. (FMB)
C19006	Research_Program_Projects_and_Centers_P-Series	Funding_Mechanisms	Research Program Projects and Centers, P-Series	P01 (Research Program Projects) support multidisciplinary or multifaceted research programs with a focused theme. P20 (Exploratory Grants) support planning for new programs, expansion or modification of existing resources, and feasibility studies to explore various approaches to the development of inter-disciplinary programs that offer potential solutions to problems of special significance to the mission of the NIH. P30 (Center Core Grants) support shared resources and facilities for categorical research by a number of investigators from different disciplines who provide a multidisciplinary approach to a joint research effort or from the same discipline who focus on a common research problem. P50 (Specialized Center Grants) support any part of the full range of research and development from very basic to clinical may involve ancillary supportive activities such as protracted patient care necessary to the primary research or R&D effort. (from NCI)
C19007	Research_Supplements_for_Underrepresented_Minorities_Notice	Program_Announcements	Research Supplements for Underrepresented Minorities, Notice	The NIH is emphasizing the use of administrative supplements to attract underrepresented minorities into biomedical and behavioral research.  Funds are available for administrative supplements to existing grants for the support and recruitment of underrepresented minority investigators and students.  The aim of these supplements is to attract and encourage minority individuals to enter and pursue biomedical and behavioral research careers in areas within the missions of all the awarding components of the NIH by providing supplemental funds to certain ongoing research grants. (from Research Supplements For Underrepresented Minorities, NIH Guide, Volume 25, Number 3, February 9, 1996)
C19008	Research_Supplements_to_Promote_the_Recruitment_of_Individuals_with_Disabilities	Institution_Supplementation	Research Supplements to Promote the Recruitment of Individuals with Disabilities	The National Institutes of Health (NIH) and its awarding components have developed this initiative to extend opportunities to individuals with qualifying disabilities who are capable of entering or resuming research careers. Under this initiative, individuals with disabilities are encouraged to pursue biomedical research careers in areas within the mission of an NIH awarding component through supplemental awards to certain ongoing research grants. It is hoped that the plan to provide funding at several different stages in a research career will substantially increase the number of individuals with disabilities in biomedical research.
C19009	Research_Training	Training	Research Training
C19010	Research-Related_Programs_S-Series	Funding_Mechanisms	Research-Related Programs, S-Series	S03: Minority High School Student Research Apprentice Program (NCRR) -To provide meaningful experience in various aspects of health-related research in the expectation that some apprentices will decide to pursue careers in biomedical research.  S06: Minority Biomedical Research Support - MBRS -To strengthen the biomedical research and research training capability of ethnic minority institutions, and thus establish a more favorable milieu for increasing the involvement of minority faculty and students in biomedical research.
C19011	Reservations	Community	Reservations	Land set apart by the Federal government for use by American Indians or tribes. (WEBS98)
C19012	Resource_Sharing	Business_Rules	Resource Sharing	The sharing of materials and data in a timely manner (from Genomic Resources For The Zebrafish, NIH Guide, Volume 26, Number 39, December 5, 1997)
C19013	Retinoid_Receptor	Nuclear_Hormone_Receptor_Superfamily	Retinoid Receptor	Member of the nuclear receptor superfamily.  These proteins specifically bind retinoids which modulate several cell functions and especially inhibit the growth of tumor cells. Three subtypes (alpha, beta, gamma) of retinoic acid receptors (RARs) have been identified.
C19014	Retrovirology	Virology_RNA_Viruses	Retrovirology	The study of RNA viruses from the family Retroviridae, which copy their genomes into DNA by action of reverse transcriptase and insert them into the host genome.
C19015	Risk_Estimate	Statistics	Risk Estimate
C19016	Risk_Factors_and_Mechanisms_of_HIV_Transmission	Funding_Category	Risk Factors and Mechanisms of HIV Transmission	Characterize the risk factors and mechanisms of HIV transmission in both domestic and international populations, with the goal of preventing transmission.
C19017	RNA_Folding	Nucleic_Acid_Folding	RNA Folding	The folding of noncontiguous stretches of RNA to produce a more compact tertiary level of structure.  Distinct stretches of RNA may be found in different conformations.
C19018	RNA_Synthesis	Polymerization	RNA Synthesis	Used to denote the transcription of DNA into RNA.  The biochemical machinery includes sequence-specific DNA binding proteins that directly act in the regulation of the transcription process, other protein factors that participate in the assembly of the transcription complex, and RNA polymerase.
C19019	RNA-Protein_Interaction	RNA_Binding	RNA-Protein Interaction	Interactions responsible for the assembly and stability of protein-RNA complexes.  Such complexes are of fundamental importance, affecting processes such as translation (ribosome), RNA processing (spliceosome), and DNA synthesis at telomeres (telomerase).  Protein structural motifs involved in RNA binding include beta sheet surfaces, alpha helices, and beta turns.
C19020	Receiver_Operator_Characteristics	Statistical_Methods	Receiver Operator Characteristics|ROC	A computational technique, receiver operator characteristics are functions that assign the maximum specificity to each value of sensitivity. The method is used for deciding which clinical data are of importance for treatment decisions in a given clinical setting. It comprises  computation of the receiver operator characteristic (ROC) functions of the compared sets of data, which are characterized by the non-linear integrals of their ROC functions.(NCI2005)
C19021	Rodent_Model	Animal_Model	Rodent Model	A rodent disease whose pathologic mechanisms are sufficiently similar to those of a human disease to serve as a model.
C19022	Small_Business_Innovation_Research_Grant	Research_Project_Grants|Small_Business_Funding_Mechanisms	Small Business Innovation Research Grant|SBIR|SBIRS (R43/44)|Small Business Innovation Research	R43/44. grant type for Small Business Innovation Research
C19023	School_Health_Nursing	Public_Health_Nursing	School Health Nursing|School Nursing	Nursing care given to those in school settings
C19024	Science_Enrichment	Patient_or_Public_Education	Science Enrichment	The addition of science courses or lectures to a school's or institution's curriculum.
C19025	Science_Policy	Policy	Science Policy	The prioritizing of science projects by a government
C19026	Scientific_Publications	Publication	Scientific Publication|Publication|Published|Scientific Publications	A class of publication in which original scientific work is described.
C19027	Senior_Scientist_Award_Guidelines	Award_Guidelines	Senior Scientist Award, Guidelines
C19028	Sensory_and_Communicative_Sciences	Information_Sciences	Sensory and Communicative Sciences
C19029	Sensory_Physiology	Physiology	Sensory Physiology
C19030	Sequencing_Biochemistry	Analytical_Biochemistry	Sequencing Biochemistry	The study of the biochemistry related to sequencing macromolecules, e.g. nucleic acids, proteins, or long-chain carbohydrates.
C19031	Shannon_Awards_Guidelines	Award_Guidelines	Shannon Awards, Guidelines
C19032	Site_Visit	Business_Rules	Site Visit	A visit from an oversite group to a site of a study or research for fact gathering, peer review, or compliance with regulations.
C19033	Skin_Carcinogenesis	Carcinogenesis	Skin Carcinogenesis	The process by which normal skin cells are transformed into cancer cells.
C19034	American_Stop_Smoking_Intervention_for_Cancer_Prevention	Educational_Intervention	American Stop Smoking Intervention for Cancer Prevention|ASSIST|Smoking, Tobacco, and Cancer-ASSIST	ASSIST builds on the research findings of previous NCI tobacco control trials that document the role of community involvement in decreasing tobacco use and controlling secondhand smoke. Conducted over a 7-year period (1991-1998), ASSIST focuses on helping smokers who want to quit, protecting nonsmokers from tobacco smoke, and discouraging the use of tobacco products among children. More than 1,000 organizations now participate in ASSIST coalitions in 17 states, with more than 91 million Americans (20 million smokers) participating. The NCI estimates that ASSIST will prevent approximately 1.2 million premature deaths due to tobacco use, including nearly 500,000 lung cancer deaths. (NCI-Questions and Answers About Finding Smoking Cessation Services)
C19035	Social_Networking	Personal_Behavior	Social Networking	Establishing relationships with individuals who have similar social or professional interests for the purposes of expanding knowledge and professional/social interaction. (Glanz et al: Heath Behavior & Health Education, 1990)
C19036	Sociobiology	Biology	Sociobiology	Sociobiology is a branch of biology that attempts to explain animal behavior and social structures in terms of evolutionary advantage or strategy. It uses techniques from ethology, evolution and population genetics. (from Wikipedia)
C19037	Somatic_Cell_Genetics	Genetics	Somatic Cell Genetics
C19038	Special_Activities_Biological_Resources	Business_Rules	Special Activities / Biological Resources
C19039	Special_Interest_Category_Clinical_Trials_Code	Business_Rules	Special Interest Category (Clinical Trials Code)
C19040	Special_Interest_Category_Special_Area_Code	Business_Rules	Special Interest Category (Special Area Code)
C19041	Spectroscopy_Circular_Dichroism	Spectroscopy	Spectroscopy, Circular Dichroism|Spectroscopy, CD/ORD	Circular dichroism (CD), optical rotatory dispersion (ORD).  Linearly polarized light can be thought of as a combination of right and left-handed circularly polarized light of equal phase and amplitude.  ORD is the phenomenon observed when a substance exhibits a difference in the index of refraction of the right vs. left circularly polarized components, resulting in a change in the plane of polarization.  When an optically active substance contains a chromophore that absorbs in the optically active region of the spectrum, CD is observed, which involves the preferential absorbance of right or left-handed circular polarized light.  Both ORD and CD depend on the wavelength of the radiation and the structure of the molecule.  Structural elements of proteins that exhibit differences in CD/ORD include the alpha helix, the beta sheet, and random coil segments.
C19042	State_and_Local_Projects_Risk_Assessment_and_Prevention	Funding_Category	State and Local Projects, Risk Assessment and Prevention	2C4b; Risk Assessment and Prevention; Information And Education/Preventive Services; General Public And Special Programs; Regional, state, and local
C19043	State_or_Local_Health_Department	Other_Agency_or_Organization	State or Local Health Department	Local and state health departments are part of the public health system that include administrative and service units concerned with the health of persons in specific jurisdictions, i.e., county or state. (Healthy People 2000, 1990)
C19044	Statistical_Methods	Computational_Technique	Statistical Methods	The use of statistics to analyze and summarize data.
C19045	Stem_Cell_Development	Histogenesis	Stem Cell Development	Differentiation of stem cells into specialized cells
C19046	Steroid_Biochemistry	Biochemistry	Steroid Biochemistry	The metabolism of steroid compounds.
C19047	Structural_Biochemistry	Biochemistry	Structural Biochemistry
C19048	Structural_Chemistry	Physical_Chemistry	Structural Chemistry
C19049	Small_Business_Technology_Transfer_Research	Research_Contracts|Research_Funding_Categories	Small Business Technology Transfer Research|STTR	A government-wide program that promotes technology transfer by helping investigators form partnerships between the private and public sectors. It differs from SBIR in being somewhat less restrictive in the level of activity permitted for academic institutions. The STTR program is a set-aside program designed to support innovative research -- that has the potential for commercialization of the subject of the research --conducted cooperatively by a small business concern and a research institution. Innovation and the potential for commercialization are two of the review criteria considered in the scientific and technical merit evaluation process. At least 40 percent of the research project is to be conducted by the small business concern and at least 30 percent of the work is to be conducted by the single, "partnering" research institution.
C19050	Support_Contracts	Grants_and_Contracts_NIH	Support Contracts
C19051	Surgery_Neonatal_Pediatric	Pediatric_Surgery	Surgery, Neonatal Pediatric	Surgery on neonates
C19052	System_for_Primary_Care_Professionals	Computer_System	System for Primary Care Professionals	Computer or Web-based programs that permit the primary care professional to screen, assess, and monitor the outcome of patient interventions or training/education programs for students.
C19053	T-Cell_Activation	Lymphocyte_Activation	T-Cell Activation	T-Cell Activation involves stimulation of T lymphocytes by receptor interaction with mitogens or cell surface-displayed antigens resulting in biosynthesis of lymphokines, cell proliferation, cell differentiation, and maturation to support immune activity.
C19054	T-Cell_Transformation	T-Cell_Activation	T-Cell Transformation	Morphologic alteration of small T lymphocytes in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by interleukins, mitogens such as phytohemagglutinins, and by specific antigens. It may also occur in vivo, as in graft rejection and chronic myelogenous leukemia, or the process that a normal T lymphocyte goes through when induced by a pathologic agent such as human T-lymphotropic virus 1 (HTLV-1) to become an adult T cell leukemia or other aggressive malignancy where neoplastic T cells apparently use IL-2 as an autocrine growth factor. (from Fundamental Immunology, 3rd ed., William Paul, ed., Raven Press, NY 1993, p.768)
C19055	T-Cell_Development	Cell_Differentiation	T-Cell Development|T-Cell Ontogeny|T-Lymphocyte Development	Development of bone marrow-derived stem cells in the thymus through stages of positive selection under the influence of epithelial cells in the thymic cortex and negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction.  Thymic T cell precursors (thymocytes) progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor.  They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells.  (NCI/OSP)
C19056	Taxonomy_Invertebrate	Taxonomy	Invertebrate Taxonomy|Taxonomy, Invertebrate	The systematic classification of invertebrates.
C19057	Taxonomy_Microbial	Taxonomy	Microbial Taxonomy|Taxonomy, Microbial	The systematic classification of bacteria.
C19058	Taxonomy_Plant	Taxonomy	Plant Taxonomy|Taxonomy, Plant	The systematic classification of plants.
C19059	Taxonomy_Vertebrate	Taxonomy	Vertebrate Taxonomy|Taxonomy, Vertebrate	The systematic classification of vertebrates.
C19060	TCR_Activation	Receptor_Activation	TCR Activation|T-Cell Receptor Interaction|TCR Interaction	TCR Activation during T cell development and proliferation involves binding to specific antigen by Ig-like heterodimeric transmembrane surface alpha/beta (antigen/MHC) or gamma/delta (antigen) glycoprotein receptors non-covalently associated with CD3 complex on T lymphocytes. Antigen-bound TCRs activate MAPKs and JNK1 through CD3 antigens, adaptor protein LAT, and tyrosine kinases LCK and ZAP70.
C19061	Theoretical_Biology	Biology	Theoretical Biology	Putting forth explanations of biological event before experimentation
C19062	Thoracic_Oncology	Oncology	Thoracic Oncology	The study of neoplasms of the thorax
C19063	Thrombosis_Hemostasis_Platelet_Function	Cell_Physiology	Thrombosis / Hemostasis / Platelet Function
C19064	Thymocyte_Selection	Thymocyte_Development	Thymocyte Selection	Bone marrow-derived stem cells in the thymus become educated to recognize complexes of self-major histocompatibility complex (MHC) molecules plus self-peptides in a process called positive selection under the influence of epithelial cells in the thymic cortex.  Positively-selected thymic T cell precursors (thymocytes) then progress through a process called negative selection under the influence of bone marrow-derived dendritic cells at the corticomedullary junction where self-reactive, and potentially autoimmunity-inducing, thymocytes are deleted.  Thymocytes simultaneously progress through phases expressing both CD4 and CD8 coreceptors to a single positive stage expressing only CD4 or CD8 in addition to the T cell receptor.  They are then allowed to leave the thymus and enter the periphery via the lymphatics or venules of the circulatory system as mature T cells.
C19065	Tissue_Specimen_Availability	Properties_or_Attributes	Tissue/Specimen Availability
C19066	Tissue_Fresh	Tissue_Sample	Tissue, Fresh	Tissue that is not frozen or embedded in preservatives
C19067	Title	Conceptual_Entities	Title	An identifying appellation signifying status or function.
C19068	TNF_Alpha_ICE_Proteinase	Protease	TNF Alpha ICE Proteinases	Tightly regulated and activated by proteolysis, TNF Alpha ICE Proteinases (ICE/CED3/Caspase Family, MEROPS C14 Peptidase Family) are Cysteine-dependent ASPartyl-specific proteASE (Caspases) effectors (active alpha2/beta2-tetrameric enzymes) of the extrinsic apoptosis cascade, induced by TNF cytokine stimulation of cell surface TNF receptors. By promoting a death-inducing signaling complex (DISC) between recruited FADD and caspase-8, activated receptors transmit signal to the cytoplasm and caspase-8 activation initiates an apoptosis cascade involving caspases 3, 4, 6, 7, 9 and 10 that destroys the cell by disintegrating its contents, including its DNA. The Caspase Family includes Caspases 1-14, ced-3 and Drosophila Ice.
C19069	Tobacco_Control_Research	Population_Sciences	Tobacco Control Research
C19070	Analytical_Toxicology	Toxicology	Analytical Toxicology|Toxicology, Analytical	A quantitative analysis of a toxic substance.
C19071	Toxicology_Antidotes_Treatment	Toxicology	Toxicology, Antidotes/Treatment	The treatment or medication that can be administered to a person who has been exposed to a toxic substance
C19072	Toxicology_Biologicals	Toxicology	Toxicology, Biologicals	The study of the toxicology of biologics.
C19073	Toxicology_Non-Drug	Toxicology	Toxicology, Non-Drug	The toxicology of compounds other than those used for therapy.
C19074	Trace_Element_Biochemistry	Biochemistry	Trace Element Biochemistry
C19075	Training_in_Biomedical_and_Behavioral_Research	Training	Training in Biomedical and Behavioral Research	Provide both domestic and international training in biomedical and behavioral research on HIV.
C19076	Training_Programs_T-Series	Funding_Mechanisms	Training Programs, T-Series	T14: Conferences--To provide the chairman of the training committee funds for operation of the review group.  T32: Institutional National Research Service Award -To enable institutions to make National Research Service Awards to individuals selected by them for predoctoral and postdoctoral research training in specified shortage areas. Also see National Research Service Award (NRSA) Stipend Increase.  T34: MARC Undergraduate NRSA Institutional Grants -To enable minority institutions to make National Research Service Awards to individuals selected by them for undergraduate research training in the biomedical and behavioral sciences.  T35: NRSA Short-Term Research Training -To provide individuals with research training during off-quarters or summer periods to encourage research careers and/or research in areas of national need.
C19077	Transcriptional_Regulation	Gene_Regulation	Transcriptional Regulation|Transcription Regulation|Transcriptional Control	The control of gene expression at the level of RNA transcription.
C19078	Transient_Gene_Knock-Out_Model	Gene_Knock-Out_Model	Transient Gene Knock-Out Model	Conditional (or inducible) gene knock-out. A transgenic technique.  A transgenic animal is constructed such that a gene of interest, or chromosome region, is flanked by recombination-signal sites (eg, loxP).  The animal is then crossed to one which carries the specific recombinase (eg, cre) under the control of a conditional, or tissue specific, promoter. Upon treatment of an inducer the recombinase is expressed, promoting recombination between the signal sites and the loss of the intervening gene or chromosome region. (NCI/OSP)
C19079	Recipient-Donor_Blood_Transmission	Transmission	Transmission, Blood, Recipient/Donor	Passage or transfer, as of a disease, by blood transfusion from a donor individual to a recipient. (NCI)
C19080	Hemophilia-Population_Blood_Transmission	Transmission	Transmission, Hemophilia Population	Passage or transfer, as of a disease, affecting recipients who suffer from hemophilia. (NCI)
C19081	Intravenous_Drug_Abuser_Blood_Transmission	Transmission	Transmission, Intravenous Drug Abuser	Passage or transfer, as of a disease, by intravenous injection with shared drug paraphernalia from a donor intravenous drug abuser to a recipient intravenous drug abuser. (NCI)
C19082	Occupationally-Related_Transmission	Transmission	Transmission, Occupationally Related	Passage or transfer, as of a disease, to a recipient individual within or due to occupational circumstances. (NCI)
C19083	Unclassified_Transmission	Transmission	Transmission, Other/Miscellaneous	Passage or transfer, as of a disease, to a recipient individual due to miscellaneous or not otherwise specified circumstances. (NCI)
C19084	Perinatal_Infectious_Transmission	Transmission	Transmission, Perinatal Infection	Passage or transfer, as of a disease, to a recipient unborn offspring in utero. (NCI)
C19085	Sexual_Transmission	Transmission	Transmission, Sexual	Passage or transfer, as of a disease, from a donor individual to a recipient during or as a result of sexual activity. (NCI)
C19086	Transplacental_Carcinogenesis	Perinatal_Carcinogenesis	Transplacental Carcinogenesis	Studies of the mechanisms of induction of cancer in an individual by in utero exposure to a carcinogen.
C19087	Transport_Models_Radionuclides	Model_System	Transport Models / Radionuclides	The use of labelled tracers for the elucidation of transport pathways.
C19088	Cellular_Transport_Process	Retired_Concepts	Cellular Transport Process|Cellular Transport|Transport, Cellular
C19089	Treat_AIDS-Related_Malignancies	AIDS_Treatment_Research	Treat AIDS-Related Malignancies	Discover, develop, and evaluate improved strategies for the treatment and prevention of HIV-associated malignancies and extend our understanding of the risk factors for and pathogenesis of such malignancies.
C19090	Treat_AIDS-Related_Neurologic_Disease	AIDS_Treatment_Research	Treat AIDS-Related Neurologic Disease	Develop strategies for assessing, preventing, and treating central and peripheral nervous system dysfunction in the course of HIV infection.
C19091	Treat_Other_HIV-Associated_Complications	AIDS_Treatment_Research	Treat Other HIV-Associated Complications	Improved understanding of the pathogenesis of these disorders can be applied to the development and evaluation of therapies for the treatment and prevention of serious HIV-associated complications, especially wasting syndrome and growth failure, as well as other disorders including hematologic, dermatologic, renal, metabolic, pulmonary, cardiac, endocrinologic, psychiatric, and oral manifestations.
C19092	TTA_System	Expression_Technologies_for_DNA_and_RNA	TTA System	Tetracycline controlled transactivator (tTA).  The original description of a tetracycline-regulated gene expression system is based on two plasmids, one of which constitutively expresses a tetracycline-controlled transactivator protein (tTA), a fusion protein between the tetracycline repressor of E. coli and the transcriptional activation domain of the VP16 protein of herpes simplex virus. The second plasmid contains the gene to be regulated by tTA under the control of an inducible promoter which consists of seven copies of the tetracycline resistance operator (tetO). Since this original description, many modifications have been described. (from Gallia GL, Khalili K. Oncogene 1998. 16:1879-84)
C19093	Tumor_Cell_Biology	Tumor_Biology	Tumor Cell Biology
C19094	Tumor_Immunity	Immunologic_Tolerance	Tumor Immunity	Mechanisms that prevent immune detection and elimination of tumor cells
C19095	Tumor_Immunology	Tumor_Biology	Tumor Immunology	Interactions of the immune system and tumor cells
C19096	Tumor_Immunology_and_Biology	Immunology	Tumor Immunology and Biology
C19097	Tumor_Pathology	Tumor_Biology	Tumor Pathology	The medical science, and specialty practice, concerned with all aspects of tumor development, growth, and metastasis, but with special reference to the essential nature, causes, and development of abnormal conditions, as well as the structural and functional changes that result from the tumor.
C19098	Tumor_Promotion	Tumor_Progression	Tumor Promotion	The second step in two-stage carcinogenesis: the conversion of an initiated (premalignant) cell to malignancy.
C19099	Cellular_Tumor_Suppression	Host-Tumor_Interaction	Cellular Tumor Suppression	Cellular Tumor Suppression is thought to involve elimination of cells that have undergone malignant transformation by patrolling cytotoxic T cells, NK cells, and macrophages due to recognition of altered cell surface antigens on the cancer cells.
C19100	Ultraviolet_Radiation_Biology	Radiation_Biology	Ultraviolet Radiation Biology	The field of science that studies the biological effects of ultraviolet radiation.
C19101	Underserved_Other_Than_Rural_Health	Funding_Category	Underserved, Other Than Rural Health|Underserved Other Than Rural Health	This includes elderly, low-literacy, blue collar, and poor populations. Minorities per se are not included but often belong to one or more or the included categories.  Does not include rural.
C19102	Urologic_Oncology	Oncology	Urologic Oncology	The medical specialty concerned with the study, diagnosis, and treatment of cancer of the genitourinary tract.
C19103	UV-Mutagenesis	Mutation	UV Mutagenesis	Heritable changes in DNA nucleotide sequence caused by exposure to ultraviolet light (UV).  UV treatment of DNA results mostly in the formation of cyclobutane pyrimidine dimers and (6-4) photoproducts.  UV-damaged DNA interferes with DNA replication and transcription, and can lead to cell killing or mutagenesis if the damage is not repaired.
C19104	V-ABL	Viral_Oncogene	V-ABL	V-ABL is an ABL oncogene of Abelson's murine leukemia virus.
C19105	V-Ras-Ha	Viral_Oncogene	V-Ras-Ha|V-Rasha	V-Ras-Ha is a transforming protein encoded by the v-Ras-Ha oncogene (or v-Ha-Ras) of Harvey murine sarcoma virus (Ha-MuSV).
C19106	V-SRC	Viral_Oncogene	V-SRC	V-Src is an oncogene of Rous Sarcoma Virus.
C19107	Viral_Cell_Proliferation	Tumor-Associated_Process	Viral Cell Proliferation	An inheritable change in cells manifested by changes in cell division and growth and alterations in cell surface properties. It is induced by infection with a transforming virus.
C19108	Viral_Envelope_Gene	Viral_Gene	Viral Envelope Gene	The genes that encode the outer structure that encloses the nucleocapsids of some viruses and may contain host material.
C19109	Viral_Epidemiology	Epidemiology	Viral Epidemiology	The use of biological techniques to study the spread and control of viral pathogens and viral disease.
C19110	Viral_Etiology_of_Cancer	Cancer_Etiology	Viral Etiology of Cancer|Viral Carcinogens
C19111	Viral_Genetics	Genetics	Viral Genetics	The branch of science concerned with the means and consequences of viral transmission and generation of the components of biological inheritance.
C19112	Virology_and_Immunopathogenesis_of_HIV	Virology	Virology and Immunopathogenesis of HIV	Delineate the cellular and molecular mechanisms associated with the viral immunopathogenesis of HIV-related immune dysfunction.
C19113	Virology_Animal	Virology	Virology, Animal	The study of animal viruses and the diseases they cause.
C19114	Virology_DNA_Viruses_Adenovirus	Virology_DNA_Viruses_General	Virology, DNA Viruses, Adenovirus	The study of adenoviruses and the diseases they cause.
C19115	Virology_DNA_Viruses_General	Virology	Virology, DNA Viruses, General	The study of DNA viruses.
C19116	Virology_DNA_Viruses_Papillomavirus	Virology_DNA_Viruses_Papovavirus	Virology, DNA Viruses, Papillomavirus	The study of papilloma viruses and the diseases that they cause.
C19117	Virology_DNA_Viruses_Papovavirus	Virology_DNA_Viruses_General	Virology, DNA Viruses, Papovavirus	The study of papova viruses and the diseases they cause.
C19118	Virology_DNA_Viruses_Polyomavirus	Virology_DNA_Viruses_Papovavirus	Virology, DNA Viruses, Polyomavirus	The study of polyoma viruses and the diseases that they cause.
C19119	Virology_Human	Virology	Virology, Human	The study of those viruses that infect humans and the diseases they cause.
C19120	Virology_RNA_Viruses	Virology	Virology, RNA Viruses	Research concerned with the origin, structure, development, growth, function, genetics, and reproduction of RNA viruses.
C19121	Visual_Physiology	Sensory_Physiology	Visual Physiology	The science concerned with the normal processes of sight.
C19122	Visual_Psychophysics	Psychobiology	Visual Psychophysics	The science of the relation between the physical organs of sight and the measured, quantitative attributes of the mental perception of a visual stimulus.
C19123	Volunteer_Organization	Volunteer_Group	Volunteer Organization|Voluntary Organizations	Organizations that volunteer their services
C19124	VPR_Gene	Viral_Gene	VPR Gene|VPR	DNA sequences that form the coding region for a trans-activator protein that specifies rapid growth in human immunodeficiency virus (HIV). vpr is short for viral protein R, where R is undefined.
C19125	Whole_Organism_Analysis	Histological_Techniques	Whole Organism Analysis	Histological techniques in which thin sections through the entire animal are used.
C19126	Whole_Organism_Cloning	Cloning	Whole Organism Cloning	Propagation of an entire organism from somatic cell material.  It was first accomplished in the 50's using frog embryonic tissues. In 1997 researchers in Scotland announced the cloning of a sheep, Dolly, using adult mammary cell DNA as the starting material. Since then several other species have been successfully cloned, including cows, mice, and monkeys.
C19127	Women_s_Health_Nursing	Nursing	Women's Health Nursing	Nursing care specifically focused on the care of the adult female.
C19128	Antisense_Technology	Molecular_Biology_Techniques	Antisense Technology	The use of nucleic acid oligomers to bind to a specific mRNA to deter protein production and halt a disease process.
C19129	Cancer_Research_Infrastructure	Research_Infrastructure	Cancer Research Infrastructure	1 or more networks, composed of health care provider organization researchers who will be capable of conducting studies of cancer epidemiology, treatment, and prevention and control. (from Cancer Research Network Across Health Care Systems, NIH Guide, Volume 26, Number 30, September 5, 1997)
C19130	Chemical_Dynamics	Physical_Chemistry	Chemical Dynamics
C19131	Deceptive_Imprinting	Disease_Progression	Deceptive Imprinting	Deceptive imprinting refers to a mechanism leading to a fixed state of immunity that fails to adapt to a changing pathogen and has lost the ability to discriminate antigen after the establishment of a strong primary immune response. (NCI)
C19132	Expression_Technologies_for_DNA_and_RNA	Molecular_Biology_Techniques	Expression Technologies for DNA and RNA	Technologies to induce the process of transcription of specific information embodied in the DNA into mRNA (messenger RNA), which is then translated into proteins.(NCI2005)
C19133	Gene_Amplification_or_Deletion_Detection	DNA_Analysis	Gene Amplification or Deletion Detection|Gene Amplification Deletion and Detection	Typically, the use of hybridization techniques to detect amplification or deletion of specific DNA sequences.  The hybridization signal of a specific sequence is compared to that of a reference sequence, usually one known to be present once per haploid genome. (NCI/OSP)
C19134	NCI_Governance	Component_of_the_National_Cancer_Institute	NCI Governance
C19135	Congress	NCI_Governance	Congress	The U.S. legislature, consisting of the Senate and the House of Representatives. (American Heritage Dictionary)
C19136	President	Component_of_NCI_Governance	President	The President of the United States of America.
C19137	NCI_Advisory_Boards_and_Groups	Component_of_the_National_Cancer_Institute	NCI Advisory Board or Group|Advice for NCI|NCI Advisory Boards and Groups
C19138	Advocates	Miscellaneous_Occupations	Advocate|Advocates	One who defends, vindicates, or espouses a cause, by argument.
C19139	Board_of_Scientific_Counselors_NCI	NCI_Advisory_Boards_and_Groups	Board of Scientific Counselors, NCI|BSC	The NCI Board of Scientific Counselors comprised of leading scientists and members of the lay community, advises the Directors of the Intramural Division of the NCI and the Director and Deputy Director, NCI, on the matters concerning scientific program policy and the progress and future direction of research programs of each Division, including the evaluation of performance and productivity of each Division and staff scientists through periodic site visits to intramural laboratories, and evaluation and advice on the course of each Division's programs.
C19140	National_Cancer_Policy_Board	NCI_Advisory_Boards_and_Groups	National Cancer Policy Board|NCPB	The NCPB is intended to confront obstacles and address issues that arise in the prevention, control, diagnosis, and treatment of cancer. It meets at least three times annually to examine ongoing research, new technologies, issues arising in delivery of care, and problems faced in the Nation's battle against cancer. It serves as a common meeting ground for the many federal agencies that sponsor or directly conduct relevant work as well as state and local health authorities. The Board's most distinctive contribution, however, will be to render advice to the Nation in the area of policy and make recommendations to advance the Nation's effort against cancer. (from http://www.nci.nih.gov/admin/fmb/2001sigitems/cancoordination.html)
C19141	Patient_or_Public_Education	NCI_Administrative_Concepts	Patient or Public Education|Patient/Public Education About Cancer
C19142	Population_Biology	Theoretical_Biology	Population Biology	Studies theoretical aspects of the biology of populations, particularly in the areas of ecology, genetics, demography, and epidemiology.
C19143	Environment-to-Cell_Communication	Cell_Signaling_Process	Environment-to-Cell Communication|Environment to Cell Communication and Signaling|Environment-to-Cell Communication and Signaling	Environment-to-Cell Communication is a process in which cells detect and respond to external conditions by various subcellular procedures.
C19144	RNA_Degradation	Post-Transcriptional_Regulation	RNA Degradation	RNA degradation is a regulated cellular biochemical process that involves depolymerization of RNA macromolecules, which affects the RNA content of cells and regulates gene expression.
C19145	Molecular_Transport	Retired_Concepts	Molecular Transport
C19146	in_vitro_Model	Experimental_Model	in vitro Model
C19147	Cell_Culture_System	Diagnostic_Therapeutic_and_Research_Equipment	Cell Culture System	Systems and reagents for the propagation of cells in tissue culture
C19148	in_vivo_Model	Experimental_Model	in vivo Model
C19149	Tumor_Development_Stage	Retired_Concepts	Tumor Development Stage
C19150	Tumor_Progression_Process	Retired_Concepts	Tumor Progression Process|Tumor Process
C19151	Metastasis	Cancer_Progression	Metastasis|MET|Tumor Cell Migration|metastasis	(meh-TAS-ta-sis) The spread of cancer from one part of the body to another. A tumor formed from cells that have spread is called a secondary tumor, a metastatic tumor, or a metastasis.  The secondary tumor contains cells that are like those in the original (primary) tumor. The plural form of metastasis is metastases (meh-TAS-ta-seez).
C19152	Molecular_Sequence_Alteration	Biochemical_Process	Molecular Sequence Alteration|Molecular Sequence Change	Any subcellular or molecular event, process, or condition that produces a divergence from the usual wild-type, germline, or pre-existing condition in the primary sequence of a biological macromolecule. (NCI)
C19153	Viral_Oncogene	Viral_Gene	Viral Oncogene	Cancer-causing genes encoded in viral genomes.  Usually denoted v-onc.
C19154	Pathologic_Mutagenesis	Pathogenesis	Pathologic Mutagenesis|Mutagenic Process|Mutagenic Process, Pathologic	Any event, process, or activity that produces a deleterious alteration of DNA. (NCI)
C19155	Patterns_of_Care	Public_Health	Patterns of Care	Addresses geographic variability in medical practice in the United States and the medical and nonmedical factors that create this variability.
C19156	Epidemiology_Other	Epidemiology	Epidemiology, Other|Other Epidemiologic Study
C19157	Specimen	Cancer_Science	Specimen|Research Specimen|SPEC|Sample	A part of a thing, or of several things, taken to demonstrate or to determine the character of the whole, e.g. a substance, or portion of material obtained for use in testing, examination, or study; particularly, a preparation of tissue or bodily fluid taken for examination or diagnosis.
C19158	Research_Infrastructure	Funding_Category	Research Infrastructure|Infrastructure	Refers to the physical structures needed to conduct research as well as the basic services needed for support, eg shipping and receiving services, waste management, and utilities.
C19159	Special_Equipment	Retired_Concepts	Special Equipment
C19160	Occupation_or_Discipline	NCI_Administrative_Concepts	Occupation or Discipline	A top level term of NCI Thesaurus
C19161	Business_Rules	NCI_Administrative_Concepts	Business Rules
C19162	Thrusts_I_II_III_IV_VI	Retired_Concepts	Thrusts I II III IV VI
C19163	Presidents_Cancer_Panel	NCI_Advisory_Boards_and_Groups	President's Cancer Panel	Consists of three persons appointed by the President, who by virtue of their training, experience, and background are exceptionally qualified to appraise the National Cancer Program. Two of the members of the Panel are distinguished scientists or physicians. Members are appointed for three-year terms. Established by Congress, December 23, 1971.
C19164	Experimental_Pathology	Pathology	Experimental Pathology	Experimental pathology; the study of disease processes by the manipulation of the natural state of an organism.
C19165	Cancer_Histology	Cancer_Biology	Cancer Histology
C19166	Reproductive_Techniques	Techniques	Reproductive Techniques	Techniques used in human and animal reproduction.(NCI2005)
C19167	Bacterial_Model	in_vivo_Model	Bacterial Model	Pathways and other molecular and cellular processes which can be manipulated in bacteria, the results of which can be extrapolated to human systems.
C19168	Fungi_Model	in_vivo_Model	Fungi Model
C19169	Plant_Model	in_vivo_Model	Plant Model
C19170	Papillomavirus_Transforming_Protein-E6	Viral_Oncogene_Protein	Papillomavirus Transforming Protein E6|E6|Viral Protein E6	Binds to and promotes degradation of p53 protein resulting in disruption of cell cycle regulation.
C19171	Papillomavirus_Transforming_Protein-E7	Viral_Oncogene_Protein	Papillomavirus Transforming Protein E7|E7|Viral Protein E7	Complexes with and inactivates Rb protein resulting in disruption of cell cycle regulation.
C19172	DNA_Polymerase	Polymerase	DNA Polymerase	Nucleotidyltransferases that catalyze the addition of deoxyribonucleotide residues to the end of a DNA.  EC 2.7.7.7 or EC 2.7.7.49
C19173	Laryngectomee	Disabled_Population	Laryngectomee|laryngectomee	(lair-in-JEK-toe-mee) A person whose larynx (voice box) has been removed.
C19174	Lower_GI_Series	Retired_Concepts	Lower GI Series|lower GI series
C19175	Pneumatic_Larynx	Medical_Device	Pneumatic Larynx|pneumatic larynx	(noo-MAT-ik LAIR-inks) A device that is used to help a person talk after a laryngectomy. It uses air to produce a humming sound, which is converted to speech by movement of the lips, tongue, or glottis.
C19176	Radioactive	General_Modifier	Radioactive|radioactive	(RAY-dee-o-AK-tiv) Giving off radiation.
C19177	Speech_Pathologist	Allied_Health_Profession	Speech Pathologist|speech pathologist	(pa-THOL-o-jist) A specialist who evaluates and treats people with communication and swallowing problems. Also called a speech therapist.
C19178	Continent_Reservoir	Surgically_Created_Structure	Continent Reservoir|continent reservoir	(KAHN-tih-nent RES-er-vwar) A pouch formed from a piece of small intestine to hold urine after the bladder has been removed.
C19179	Electrolarynx	Medical_Device	Electrolarynx|electrolarynx	(e-LEK-tro-LAIR-inks) A battery-operated device that makes a humming sound.  It is used to help a person talk after removal of the larynx (voice box).
C19180	Enterostomal_Therapist	Allied_Health_Profession	Enterostomal Therapist|enterostomal therapist	(en-ter-o-STO-mul) A health professional trained in the care of persons with urostomies and other stomas.
C19181	Antismoking	Funding_Category	Antismoking
C19182	B_A_D_Codes	Code	B.A.D. Codes|Basic, Applied, Development Codes	Basic, Applied, Development codes.
C19183	Causation_Research_Budget_Activity	Funding_Category	Causation Research (Budget Activity)
C19184	Colon_Rectum	Funding_Category	Colon, Rectum	Funding category for dollars spent on studies having to do with the large intestine (colon) or the rectum.
C19185	Control_Budget_Activity	Funding_Category	Control (Budget Activity)
C19186	Core_Assembly	Viral_Function	Core Assembly	Assembly of virus core. (NCI)
C19187	Diagnostic_Radiology_Ionizing_and_Nonionizing	Radiology	Diagnostic Radiology (Ionizing and Nonionizing)	The use of ionizing or nonionizing radiation for diagnostic purposes.
C19188	Genetic_Engineering_Applied	Genetic_Engineering	Genetic Engineering, Applied	Genetic engineering performed with the object of creating, modifying or otherwise enhancing a product whose manufacture is partly or entirely dependent on a biological process.
C19190	Lung_Cancer_Women_Subset_of_Total_Lung	Costs	Lung Cancer, Women (Subset of Total Lung)	Budget category.
C19191	Mason_Codes	Code	Mason Codes|Mason Code	Functional category code.
C19192	Medicine_Non-Malignant_Disease	Medicine	Medicine, Non-Malignant Disease	Medicine related to non-malignant disease
C19193	Primary_Nutrition_NCI_Program	Funding_Category	Primary Nutrition (NCI Program)
C19194	Urologic_Excluding_Kidney	Funding_Category	Urologic (Excluding Kidney)	A funding category.
C19195	MSH6_Gene	DNA_Repair_Gene	MSH6 Gene|GTBP|HNPCC5|MSH6|MutS Homolog 6 (E. coli) Gene	The MSH6 gene encodes the G/T Binding Protein (GTBP), which forms Mismatch-Binding Factor with MSH2. GTBP contains a PWWP domain, binds to G/T mismatches, is required for base/base and single-nucleotide insertion-deletion repairs, and increases the proficiency of two-four nucleotide insertion-deletion repair. ADP-bound MSH2/MSH6 binds to mismatched DNA, provoking ADP/ATP exchange and MSH2/MSH6 migration along the DNA backbone. DNA-bound, ATP-bound MSH2/MSH6 activates the repair machinery. MSH6 is part of the multisubunit BASC complex, which may sense abnormal DNA structures and regulate postreplication repair. Associated with colon, endometrial, and stomach cancers, the MSH6 Gene (MUTS family) at 2p16 is a cloned gene for Hereditary Non-Polyposis Colon Cancer. (from SWISS-PROT, OMIM, and NCI)
C19196	Not_Site_Specific	Business_Rules	Not Site Specific|No Specific Site
C19197	Small_Business_Funding_Mechanisms	Funding	Small Business Funding Mechanisms|SBIR	Government-wide programs to promote technology transfer.
C19198	Strategic_Code	Code	Strategic Code|Strategic Plan Code
C19199	Health_Sciences	Occupation_or_Discipline	Health Sciences
C19200	Experimental_Psychology	Psychology	Experimental Psychology
C19201	AIDS_Treatment_Research	Research_Funding_Categories	AIDS Treatment Research
C19202	National_Cancer_Institute	Professional_Organization_or_Group	National Cancer Institute|NCI|NCI Organization	NCI.  The National Cancer Institute, part of the National Institutes of Health of the United States Department of Health and Human Services, is the Federal Government's principal agency for cancer research.  NCI conducts, coordinates, and funds cancer research, training, health information dissemination, and other programs with respect to the cause, diagnosis, prevention, and treatment of cancer.  Access the NCI Web site at http://cancer.gov.
C19203	Office_of_the_Director	Component_of_the_National_Cancer_Institute	Office of the Director|NCI Director|NCI Office of the Director	Office of the NCI Director serves as the focal point for the National Cancer Program; develops a National Cancer Plan and monitors implementation of the plan; directs and coordinates the Institute's programs and activities; and develops and provides policy guidance and staff direction to the Institute's programs in areas such as program coordination, program planning, clinical care and administrative management.
C19204	Office_of_International_Affairs	Office_of_the_Director	Office of International Affairs
C19205	Office_of_Centers_Training_and_Resources	Component_of_the_Office_of_the_Director	Office of Centers, Training, and Resources
C19206	Office_of_Special_Populations_Research	Office_of_the_Director	Office of Special Populations Research|OSPR	The Office of Special Populations Research was established in 1996 to advise the Director of NCI and provide a focal point for leadership and coordination on minority and other special populations research.
C19207	Office_of_Budget_and_Financial_Management	Office_of_the_Director	Office of Budget and Financial Management
C19208	Office_of_Legislative_and_Congressional_Activities	Office_of_the_Director	Office of Legislative and Congressional Activities
C19209	Journal_of_the_National_Cancer_Institute	Scientific_Publications	Journal of the National Cancer Institute|Journal of the NCI	The Journal of the National Cancer Institute publishes manuscripts that describe new findings of particular significance in any area relating to cancer, as well as associated news items, reviews, and opinion pieces.  The Journal endeavors to appeal to a broad, multidisciplinary audience.  Contents include: Peer-reviewed reports on major oncology studies from around the world; Editorials and commentary by leading experts on key articles and current controversies in cancer; The latest news from the oncology community, book reviews, and conference and position announcements. (from JNCI Information for Authors)
C19210	Office_of_Science_Planning_and_Analysis	Component_of_the_Office_of_the_Director	Office of Science Planning and Analysis
C19211	Office_of_Cancer_Genomics	Component_of_the_Office_of_the_Director	Office of Cancer Genomics
C19212	Office_of_Science_Opportunity	Component_of_the_Office_of_the_Director	Office of Science Opportunity
C19213	Office_of_Management	Office_of_the_Director	Office of Management
C19214	Office_of_Liaison_Activities	Component_of_the_National_Cancer_Institute	Office of Liaison Activities	Formed to act as a central point of contact and NCI link to cancer advocacy organizations.  Recently rolled into the Office of Communications.
C19215	Division_of_Basic_Sciences	Component_of_the_Center_for_Cancer_Research	Division of Basic Sciences	Merged with the Division of Clinical Sciences in January, 2001 to form the Center for Cancer Research
C19216	Extramural_Research_Program	Component_of_the_Division_of_Extramural_Activities	Extramural Research Program	The Extramural Research Program supports the work of scientists in universities, teaching hospitals, and other organizations outside NCI. (from NCI website)
C19217	Division_of_Cancer_Control_and_Population_Sciences	Component_of_the_National_Cancer_Institute	Division of Cancer Control and Population Sciences|DCCPS
C19218	NCI_Board_of_Scientific_Advisors	Retired_Concepts	NCI Board of Scientific Advisors|BSA
C19219	Prevention_Clinical_and_Therapeutic_Subcommittee	Board_of_Scientific_Advisors_NCI	Prevention, Clinical, and Therapeutic Subcommittee|PCT
C19220	Cancer_Biology_Epidemiology_and_Genetics_Subcommittee	Board_of_Scientific_Advisors_NCI	Cancer Biology, Epidemiology, and Genetics Subcommittee|CBEG
C19221	Subcommittee_B_Basic_Sciences	Board_of_Scientific_Counselors_NCI	Subcommittee B, Basic Sciences|BSC, Basic Sciences	Subcommittee of the Board of Scientific Counselors, NCI, which advises the Directors of the Intramural Division of the NCI and the Director and Deputy Director, NCI, on a wide variety of matters concerning scientific program policy and the progress and future direction of research programs of each Division, including the evaluation of performance and productivity of each Divison, the evaluation of performance and productivity of staff scientists through periodic site visits to intramural laboratories, and evaluation and advice on the course of each Division's programs.
C19222	Subcommittee_A_Clinical_Sciences_and_Epidemiology	Board_of_Scientific_Counselors_NCI	Subcommittee A, Clinical Sciences and Epidemiology|BSC, Clinical Sciences	Subcommittee of the Board of Scientific Counselors, NCI, which advises the Directors of the Intramural Division of the NCI and the Director and Deputy Director, NCI, on a wide variety of matters concerning scientific program policy and the progress and future direction of research programs of each Division, including the evaluation of performance and productivity of each Division, the evaluation of performance and productivity of staff scientists through periodic site visits to intramural laboratories, and evaluation and advice on the course of each Division's programs. (http://deainfo.nci.nih.gov/ADVISORY/bscfo.htm)
C19223	Other_Agency_or_Organization	Professional_Organization_or_Group	Other Agency or Organization|Outside Bodies
C19224	Department_of_Energy	Other_Agency_or_Organization	Department of Energy|DOE
C19225	Department_of_Defense	Other_Agency_or_Organization	Department of Defense|DOD	Department of Defense (DOD). According to the FY2004 Defense Appropriations Act, DOD is responsible for funding of several cancer research programs such as studies on breast, ovarian, and prostate cancer, leukemia, and myeloproliferative disease.
C19226	Advisory_Committee_to_the_NCI_Director	NCI_Advisory_Boards_and_Groups	Advisory Committee to the Director, NCI|ACD|Advisory Committee to the Director, National Cancer Institute|Committee to the Director, NCI	The Committee advises and makes recommendations to the Director, NCI, for the oversight and integration of various planning and advisory groups serving the broad programmatic and institutional objectives of the Institute. The Committee serves as the official channel through which the findings and recommendations emerging from these groups are submitted to the NCI. The Committee may consider the reports of the various review groups as informational, advisory, or as recommendations, and shall provide the NCI with assistance in identifying opportunities to be pursued within the areas of cancer research that cut across the intramural and extramural programs.
C19227	NCI_Director_s_Consumer_Liaison_Group	Advisory_Committee_to_the_NCI_Director	NCI Director's Consumer Liaison Group|DCLG	The Director's Consumer Liaison Group (DCLG) is a group of fifteen members of the cancer advocacy community who were convened to help NCI increase the representation of the cancer advocacy community on NCI advisory committees, and increase their involvement in program and policy development.  DCLG members will interact directly with the scientific community at NCI on a wide range of programs and issues. The DCLG will also help NCI to widen the pool of qualified consumer-advocates who can be called upon to serve on NCI advisory committees and other groups. (2/99)
C19228	Optical_Instrument	Medical_Device	Optical Instrument|Optics / Optical Instrument|Optics/Optical Instrument	An instrument used to measure an event involving emission, absorption, or refraction of light.
C19229	SSCP_Analysis	Conformation_Dependent_Mutation_Detection	SSCP Analysis|Single-Strand Conformation Polymorphism Analysis	A research technique used to demonstrate nucleotide sequence variations that occur in the same region of DNA between individuals within a species, or between alleles in an individual to detect mutations in various genes, such as oncogenes, tumor suppressor genes, or genes responsible for genetic diseases. The method detects different conformations adopted by partially denatured DNA fragments resulting from their specific nucleotide sequences under denaturing conditions. Denatured single-stranded DNA fragments are allowed to partially renature without formation of double-stranded DNA. The particular conformations adopted by each of the renatured fragments depend on each of their specific nucleotide sequences. The fragments are run on polyacrylamide gels to detect subtle changes in migration due to their particular secondary structures. Resulting fragment band in the gel will misalign if any point mutations are present to alter the conformation.
C19230	Dideoxy_Fingerprinting	Conformation_Dependent_Mutation_Detection	Dideoxy Fingerprinting	A variation of SSCP analysis in which the DNA fragments are generated by chain terminating sequencing reactions.  Can be more sensitive due to the increased number of fragments, only a small number of which might display an altered migration.
C19231	Autoradiography_Gross	Autoradiography	Autoradiography, Gross
C19232	Preservation_Technique	Techniques	Preservation Technique	Techniques and methods utilized to preserve biological material in a living state.
C19233	Computational_Technique	Techniques	Computational Technique|Computational	The utilization or development of computer programs to solve, analyze, understand or manage any simple or complex task.
C19234	Homology_Modeling	Molecular_Modeling	Homology Modeling	This is an approach to modeling a protein structure based on an initial sequence alignment to a protein with a known 3D structure.  After evaluating and resolving structural irregularities in the initial model, it may be further refined using energy minimization and other procedures.
C19235	Molecular_Biology_Techniques	Research_Techniques	Molecular Biology Techniques	The methods and tools used for DNA analysis and manipulation
C19236	Physical_Chemical_Techniques	Research_Techniques	Physical Chemical Technique	Techniques based on the principles of physical and chemical science, for the study of biological problems. (NCI2005)
C19237	Subcommittee_to_Evaluate_the_National_Cancer_Program	Presidents_Cancer_Panel	Subcommittee to Evaluate the National Cancer Program|SENCAP
C19238	Diagnostic_Therapeutic_and_Research_Equipment	root_node	Diagnostic, Therapeutic, and Research Equipment|Equipment|Hardware	An object needed to perform a diagnostic, therapeutic or research activity.
C19239	AIDS_Infant_Mortality	Infant_Mortality	Infant Mortality, AIDS|AIDS, Infant Mortality	AIDS related research with a minimum of 20% (or $100,000) research efforts related to deaths of children under 1 year of age. (FMB)
C19240	Deletion_Mutagenesis	Mutagenesis	Deletion Mutagenesis	Mutagenesis where the mutation is caused by the loss of DNA sequences within a gene. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro.
C19241	S1_Protection	RNA_Analysis	S1 Protection	Molecular biology technique used to determine the 5' end or 3' end of a nucleic acid molecule, or the location of the junction between spliced molecules.  Used most commonly to determine the 5' end of RNA transcripts.  Based on the protection afforded an end-labeled DNA probe from nuclease S1 digestion after hybridization with a target molecule.  The length of the protected probe indicates the end or molecular junction of the target nucleic acid sequence.
C19242	NEO_Gene	Reporter_Gene	NEO Gene|NEO|Neomycin Resistance Gene	The NEO Gene confers resistance to the aminoglycoside antibiotic neomycin. NEO is widely used in genetic research because of the easily selectable phenotype.
C19243	Luc_Gene	Reporter_Gene	Luc Gene|Luciferase Gene	Luc Genes encode Luciferase, flavoprotein enzymes in certain marine crustaceans, fish, bacteria, and insects that catalyze bioluminescent oxidization of Luciferins to an electronically excited compound that emits energy in the form of light. The firefly enzyme is a valuable reagent for measurement of ATP concentration. (NCI)
C19244	Socioeconomics	Sociology	Socioeconomics	The study of the economic, demographic, and social interactions of humans. (Lake and Water word glossary; http://www.nalms.org/glossary/glossary.htm)
C19245	Social_Sciences_Other	Social_Sciences	Social Sciences, Other
C19246	DNA_Ligation	Molecular_Biology_Techniques	DNA Ligation	The joining together of two or more nucleic acid molecules by the action of ligase
C19247	Biomedical_Computing	Bioengineering	Biomedical Computing
C19248	Cost_Effective_Management	Medical_Economics	Cost Effective Management
C19249	Cost_Effectiveness_Analysis	Cost_Benefit_Analysis	Cost Effectiveness Analysis|Analysis of Cost Effectiveness|Cost Effective Analyses
C19250	Economic_Burden	Medical_Economics	Economic Burden
C19251	Stage_at_Diagnosis	Stage	Stage at Diagnosis
C19252	Surveillance_Methods	Research_Techniques	Surveillance Methods	Methods used for potential identification of emerging disease threats and/or outbreaks so that public health personnel can take protective measures and minimize their impact on the health and economy of the world's population.(NCI2005)
C19253	Comorbidity_Index	Vital_Statistics	Comorbidity Index	In epidemiology, a rating scale for comorbidity.
C19254	Medical_Occupation	Occupation	Medical Occupation|Health Care Occupation	Occupations within the field of medicine.
C19255	B-Cell_Activation	Lymphocyte_Activation	B-Cell Activation	A set of events occurring in B lymphocytes following stimulation with cognate antigen.  Crosslinking the B cell antigen receptor (surface immunoglobulin) leads to increased expression of MHC class II molecules, exit from the resting state (G0) into the G1 phase of the cell cycle, and in the case of a strong antigenic stimulus, proliferation.
C19256	Cancer_Genetics_Network	Professional_Organization_or_Group	Cancer Genetics Network|CGN	A network dedicated to studying inherited predispositions to cancer.  Includes 8 centers and an informatics and information technology group.  It will integrate discoveries into medical applications and address psychosocial, ethical, legal and other implications related to inherited genetic susceptibility.
C19257	Molecular_Epidemiology_of_Prostate_Cancer	Cancer_Research_Project	Molecular Epidemiology of Prostate Cancer	The objective is to examine the role of genes that regulate the metabolism of environmental carcinogens in prostate cancer etiology.  These genes include cytochromes P450 (e.g. CYP1A1, CYP2D6, and CYP2E1) and the mu or theta classes of the glutathione-S-transferases.  Three specific aims are proposed to accomplish this objective.  In Specific Aim l, the relationship of each of the candidate genes and the occurrence or age of onset of prostate cancer will be examined.  The relationship between multiple candidate genes and the occurrence or age of onset of prostate cancer will be examined in Specific Aim 2.  The interactions of multiple candidate genes, environments, and exposures will be examined in Specific Aim 3.  (from EGP Research Programs, PI: Timothy R. Rebbeck, University of Pennsylvania, R29_ES_08031_03)
C19258	Cancer_Center_Supplements	Institution_Supplementation	Cancer Center Supplements	To stimulate the development of resources and pilot projects in human cancer genetics.
C19259	International_Consortium_on_Prostate_Cancer_Genetics	NCI_Consortium_or_Network	International Consortium on Prostate Cancer Genetics|ICPCG	International consortium of over 25 groups and multiple investigators pursuing collaborative research on the epidemiology of prostate cancer. The consortium was first promoted and supported by the NCI's Epidemiology and Genetics Program in 1995. Investigators are funded primarily by the NCI for their individual research projects (RO1s) while the National Institute for Human Genome Research contributes an intramural component. Current research focuses primarily on the discovery and characterization of prostate cancer susceptibility genes. Collaborations are established through communications and agreements with the participating groups.
C19260	Mouse_Models_of_Human_Cancer	Rodent_Model	Mouse Models of Human Cancer	A neoplastic disease of a mouse with clinical features sufficiently similar to those of a human cancer to serve as a test system.
C19261	Non-Mammalian_Organisms_as_Models_for_Cancer	Animal_Model	Non-Mammalian Organisms as Models for Cancer	Studying the origins, progression, and treatment of cancer in a non-mammalian organism
C19262	Exploratory_Developmental_Grant_for_Diagnostic_Cancer_Imaging	Exploratory_Developmental_Grant	Exploratory/Developmental Grant for Diagnostic Cancer Imaging|R21 Award	The Diagnostic Imaging Program (DIP), of the Division of Cancer Treatment and Diagnosis (DCTD) solicits exploratory/developmental (R21) grants that articulate highly innovative research concepts in diagnostic cancer imaging to provide investigators with the initial resources required to accomplish feasibility and pilot testing of innovative ideas. The R21 mechanism will provide investigators at all career levels with a defined level of funding adequate for the initial feasibility testing of high risk/high impact concepts and, if the concepts are viable, for the generation of experimental preliminary data. This would render the investigators competitive for funding through the research project grant (R01) and/or First Independent Research Support and Transition (FIRST) (R29) award mechanisms, thus potentially leading to the establishment of new research programs in areas that might have previously remained unexplored.
C19263	Laser_Capture_Microdissection	Microdissection	Laser Capture Microdissection	Laser capture microdissection is a new technology developed in the Intramural Program to allow sampling of specific cells under direct microscopic visualization by a pathologist. A film is placed against the heterogeneous tissue and activated by a laser beam to capture only the cells of interest. Those cells are transferred to the film to provide a visual microscopic record of what was transferred, which can be analyzed for DNA, RNA, or protein.  The film upon which the cells are transferred is incorporated into the cap of a vial so that, when the transfer is done under a routine microscopic visualization, the microdissected material can immediately be put into a vial for processing. The system is integrated into a pathologist's microscope so that the cells are microdissected, transferred to the cap, and then rotated into a vial by a rotating arm in a hands-off operation. (from Cancer Genome Anatomy Project (CGAP) Update)
C19264	Phased_Innovation_Awards	Research_Project_Grants	Phased Innovation Awards|R21/R33 Mechanism|R21/R33 Program	Provide a funding mechanism for developing and testing new technologies that underlie discovery in all aspects of cancer research.
C19265	Early_Detection_Research_Network	Cancer_Research_Network	Early Detection Research Network|EDRN|National Detection Research Network	Established by NCI to identify and evaluate molecular biomarkers and technologies for earlier detection and risk assessment of all major cancers. The EDRN is a national network of academic and industry investigators with expertise in laboratory and clinical sciences, biostatistics, informatics, and public health.
C19266	Immune_Surveillance	Immune_Function	Immune Surveillance	Immune Surveillance refers to T cell circulation through tissues and destruction of virally infected cells (and possibly cancer cells) that induce T cell activation due to expression of foreign antigens.
C19267	Biochemistry_and_Pharmacology_Cancer_Activity	Cancer_Research_Project	Biochemistry and Pharmacology Cancer Activity|Biochemistry and Pharmacology	Preclinical studies designed to improve cancer treatment; emphasis on discovery of new drugs and treatment strategies, selective targeting, development of new preclinical models, and understanding, preventing, and overcoming drug resistance.  NCI Cancer Activity: used for grant referral to programs)
C19268	Resource_Informatics	Informatics	Resource Informatics	The field of information science concerned with the analysis and dissemination of medical data through the application of computers to various resource aspects of health care and medicine.  Resources may include databases (drug structures, gene sequences, genealogical data, insurance records, tumor registries), software, cell or tissue banks, or other collections available for use in research.
C19269	Howard_Temin_Award	Mentored_Research_Scientist_Development_Award	Howard Temin Award|Bridging Award|Howard Temin Award (K01)	The goal of the National Cancer Institute's (NCI) Howard Temin Award is to bridge the transition from a mentored research environment to a National Cancer Institute independent research career for scientists who have demonstrated unusually high potential during their initial stages of training and development. This special award is aimed at fostering the research careers of outstanding, junior, basic, clinical, and behavioral scientists who are committed to developing research programs highly relevant to the understanding of human biology and human disease as it relates to the etiology, pathogenesis, prevention, diagnosis, and treatment of cancer.
C19270	Independent_Scientist_Award	Mentored_Research_Scientist_Development_Award	Independent Scientist Award|ISA|K02 Award	The Independent Scientist Award (ISA) (K02) provides support for newly independent scientists who can demonstrate the need for a period of intensive research focus as a means of enhancing their research careers.  This award is intended to foster the development of outstanding scientists and enable them to expand their potential to make significant contributions to their field of research.
C19271	Diagnostic_Imaging_Network	Cancer_Research_Network	Diagnostic Imaging Network|Diagnostic Imaging Cooperative Studies Network	Initiative to bring together imaging experts from around the nation to perform multi-institutional clinical trials on diagnostic imaging tools related to cancer. (Bypass Budget)
C19272	Transgenic_Model	Animal_Model	Transgenic Model	A disease in a transgenic animal with pathologic mechanisms sufficiently similar to those of a human disease for the animal disease to serve as a model.
C19273	Heterotrimeric_G_Protein_Subunit	G_Protein	Heterotrimeric G Protein Subunit	The alpha, beta, and gamma subunits (or beta-gamma dimers) of heterotrimeric guanine nucleotide binding (G) proteins are intracellular membrane-associated proteins activated by various receptors (e.g., beta adrenergic).  They serve as transducers of the receptor-initiated response linked to intracellular elements, such as enzymes, that generate second messengers to initiate an effect.  These proteins have a high affinity for guanine nucleotides and hence are named "G" proteins.
C19274	G_Beta_Gamma	Protein_or_Riboprotein_Complex	G Beta Gamma	G beta-gamma dimers associate with the alpha subunit to comprise heterotrimeric G proteins.  This dimer stimulates various, and sometimes opposing, cell signaling events in response to ligation of a G protein coupled receptor, such as the beta-adrenergic, adenosine, dopamine, LTB4, and PGE2 receptors, among many others.
C19275	G-i_Alpha	Heterotrimeric_G_Protein_Subunit	G(i) Alpha|Adenylate Cyclase-Inhibiting G Alpha Protein|G Protein Alpha Inhibiting Polypeptide|G(i) Alpha Protein	Human G(i) Alpha Proteins (G-Alpha 1 Family) are 40-kDa guanine nucleotide-binding alpha protein subunits of heterotrimeric G protein transducers (alpha, beta, gamma) in transmembrane signaling systems involved in hormonal regulation of adenylate cyclase. Containing virtually identical/similar beta and gamma chains, G proteins are most distinguished by alpha chains. G(i) proteins (alpha(i) subunit) inhibit cyclase in response to beta-adrenergic stimuli. Specific alpha chain regions appear to interact with guanine nucleotides, receptors, effector enzymes, and G protein beta-gamma complex. G proteins that inhibit adenylate kinase and regulate other plasma membrane enzymes are substrates for pertussis toxin. (NCI)
C19276	G-q_Alpha	Heterotrimeric_G_Protein_Subunit	G(q) Alpha	the alpha subunit of the G(q) class of heterotrimeric G proteins.
C19277	G_12_13_Alpha	Retired_Concepts	G(12/13) Alpha	The alpha subunit of the G(12/13) class of heterotrimeric G proteins.
C19278	Grb-2	Retired_Concepts	Grb-2
C19279	Information_Sciences_Other	Information_Sciences	Information Sciences, Other
C19280	Community_Oncology_and_Rehabilitation_Branch	Component_of_the_Division_of_Cancer_Prevention	Community Oncology and Rehabilitation Branch|CORB	Part of the Division of Cancer Prevention.  Develops programs to improve clinical oncology in community settings and coordinates community oncology program activities with the activities of other research programs of the National Cancer Program; Promotes interaction between community oncologists and regional or national clinical cooperative groups; Stimulates psychosocial and physical rehabilitation research; Develops and conducts research on the management of cancer pain; develops research in the area of supportive care for patients and families; Studies the impact of cancer control programs on the community; and Conducts preliminary Phase II cancer control) studies of education, attitudes, and behavior of physicians, nurses, and other health professionals to serve as the basis for subsequent cancer control studies.
C19281	Public_Health_Applications_Research_Branch	Component_of_the_Division_of_Cancer_Prevention	Public Health Applications Research Branch|PHARB	Part of the Division of Cancer Prevention and Control.  develop a research and applications program to support public health agencies in their cancer control efforts.  regularly and systematically assess community health needs, develop comprehensive public health policies based on the use of scientific knowledge, and assure the provision of services necessary to meet agreed-upon goals.
C19282	Immunology_Other	Immunology	Immunology, Other	This term is used as a form filler when there is no appropriate Immunology term available.
C19283	Cytochrome-P450-2D5	Rat_Protein	Cytochrome P450 2D5|CYP2D5	Cytochrome P450 2D5 is a rat liver ER membrane-bound heme-thiolate monooxygenase, involved in an NADPH-dependent electron transport pathway that oxidizes various compounds, including steroids, fatty acids, and xenobiotics.  Expression is induced in liver and other tissues by drugs, pesticides, and carcinogens.
C19284	syk_Family_Tyrosine_Kinase	Protein_Tyrosine_Kinase	syk Family Tyrosine Kinase	Family of non-receptor protein tyrosine kinases similar to the syk protein (spleen tyrosine kinase) containing two SH2 (src homology 2) domains. They play essential roles in a variety of immune and non-immune cells.
C19285	TNF_Receptor_Family_Protein	Cytokine_Receptor	TNF Receptor Family Protein|TNF Receptor|TNF Receptor Superfamily|TNFR|Tumor Necrosis Factor Receptor|Tumor Necrosis Factor Receptor Family|Tumor Necrosis Factor Receptor Superfamily	Members of the tumor necrosis factor receptor (TNFR) family play a key role in regulating the immune response to infection.  They are cell-surface proteins that interact with a corresponding TNF-related ligand family. The receptors share homology in the extracellular domain, which contains 3 to 6 cysteine-rich pseudorepeats, but are generally not related in their cytoplasmic regions. However, the intracellular domains (ICDs) of TNFR family members TNFR1 and FAS/APO1/CD95, which can activate apoptotic cell death, do have a region of homology in an oligomerization interface known as the death domain. (from OMIM 603366)
C19286	Tissue_Slice_Technology	Organ_Model	Tissue Slice Technology	A technology used for preclinical research as an alternative to some animal testing.  Micrometer-thin slices of various organs are incubated with various experimental compounds for assays involving toxicology, absorption, distribution, and metabolism.
C19287	Commercial_Sources	Business_Rules	Commercial Sources	A category used for classifying sources of research reagents not obtained through academic institutions.
C19288	Non-Commercial_Sources	Business_Rules	Non-Commercial Sources	A category used for classifying sources of research reagents obtained through academic institutions.
C19289	Research_Project_Grants	Grants	Research Project Grants|R01 Mechanism|R01 Program|RPG|Research Grants|Research Projects|Research Projects, R-Series	A financial assistance mechanism providing money, property, or both to an eligible entity to carry out an approved project or activity.
C19290	Blue-Collar_Group	Underserved_Population	Blue-Collar Group	Blue-Collar Group; refers to workers doing skilled or semi-skilled manual labor.  A traditionally underserved population.
C19291	Epidemiological_Factors	Conceptual_Entities	Epidemiological Factors	Epidemiological factors are the identifiable and quantifiable things which contribute to the establishment and transmission of disease.
C19292	Organ_Transplant_Research	Research_Funding_Categories	Organ Transplant Research	Research to successfully transfer an organ from one individual to another of the same or a different species.
C19293	Pathology_Other	Business_Rules	Pathology, Other	An indication that none of the enumerated Pathology types are applicable.
C19294	Parasitology_Other	Parasitology	Parasitology, Other	This term is used as a form filler when there is no appropriate Parasitology term available.
C19295	Insertion_Mutation	Mutation	Insertion Mutation|Mutation, Insertion	Mutations that result in the insertion of one or more nucleotides into a wild type DNA sequence.  Can result in a frame shift in the coding sequence of a gene.
C19296	Deletion_Mutation	Mutation	Deletion Mutation|Mutation, Deletion	A Deletion Mutation is a loss of any genetic material on a chromosome, ranging from loss of a single nucleotide, to loss of part or all of a gene, to loss of a visible portion of the chromosome involving multiple genes. Deletions often disrupt gene or protein function and cell function as a result.
C19297	Neurosciences_Other	Neurosciences	Neurosciences, Other
C19298	Nursing_Sciences_Clinical	Clinical_Sciences	Nursing Sciences, Clinical
C19299	Fetal_Thymic_Organ_Culture	Organ_Culture	Fetal Thymic Organ Culture|FTOC	Fetal Thymic Organ Culture.  A cell culture system where fetal thymic cells are grown in vitro.
C19300	Non-Rodent_Model	Animal_Model	Non-Rodent Model	Research animal models that do not include mice, rats, etc, but that might include non-human primates, cats, dogs, and others.
C19301	Comparative_Biology	Biology	Comparative Biology	Biological field of study concerned with the analysis of similarities and differences in specific traits between different species.
C19302	Psychology_Other	Psychology	Psychology, Other
C19303	Radiation_Biology_Other	Radiation_Biology	Radiation Biology, Other
C19304	Magnetic_Bead_Technology	Cell_Sorting	Magnetic Bead Technology	A cell-separation technique where magnetizable microspheres or beads are first coated with monoclonal antibody, allowed to search and bind to target cells, and are then selectively removed when passed through a magnetic field. Among other applications, the technique is commonly used to remove tumor cells from the marrow of patients who are to undergo autologous bone marrow transplantation.
C19305	CTLL-2_Assay	Cytotoxic_T-Lymphocyte_Analysis	CTLL-2 Assay|Cytotoxic T Lymphocyte Line-2 Assay|IL-2 Assay	A bioassay used in the detection of interleukin-2 (IL-2) or interleukin-4 (IL-4) in the supernatants of in vitro-stimulated cells.  It relies on the IL-2- or IL-4-dependence of a cytotoxic cell line (CTLL-2) for in vitro proliferation, and the measurement of the growth of the these cells is usually determined by tritiated-thymidine incorporation pulsed into the CTLL-2 culture 8-12 hours immediately prior to harvesting the CTLL-2 cells.
C19306	Hollow_Fiber_Apparatus	Cell_Culture_System	Hollow Fiber Apparatus	Any apparatus which makes use of hollow fiber technology to increase the yield of surface area-dependent processes, such as dialysis and cell culture of attachment-dependent cells.
C19307	Physiology_Other	Physiology	Physiology, Other	The science concerned with the normal vital processes of animal and vegetable organisms, especially as to how things normally function in the living organism rather than to their anatomical structure, their biochemical composition, or how they are affected by drugs or disease.
C19308	Average_Household_Income	Socioeconomic_Factors	Average Household Income	A demographic parameter indicating the amount of earnings made by a family.
C19309	Number_of_Children_in_Household	Socioeconomic_Factors	Number of Children in Household	a demographics parameter useful for identifying socio-economic groups.
C19310	Statistics_Other	Statistics	Statistics, Other	This term is used as a form filler when there is no appropriate Statistics term available.
C19311	Biologic_Permissiveness	Immunologic_Tolerance	Permissiveness, Biological Function|Permissiveness	Allowing establishment of infection or acceptance of graft material.
C19312	Long_Term_Survivorship	Survival	Long Term Survivorship	The situation where a person has survived a disease for years
C19313	Cryopreserved_Tissue	Tissue_Sample	Cryopreserved Tissue	Tissues which are indefinitely maintained in a viable state at extremely low temperatures.
C19314	Cryopreserved_Cell	Specimen	Cryopreserved Cell	Cells which are indefinitely maintained in a viable state at extremely low temperatures.
C19315	Primary_Cell_Culture	Cell_Culture	Primary Cell Culture|Culturing, in vitro Vertebrate, Primary	The cells taken from a tissue source, and their progeny, grown in culture before subdivision and transfer to a sub culture. (On-line Medical Dictionary)
C19316	Allied_Health_Sciences	Health_Sciences	Allied Health Sciences	Occupations of medical personnel who are not physicians, and are qualified by special training and, frequently, by licensure to work in supporting roles in the health care field. These occupations include, but are not limited to, medical technology, physical therapy, physician assistant, etc.
C19317	Thymocyte_Development	T-Cell_Development	Thymocyte Development	progression of T cell precursors in the thymus through many stages of maturation.  These stages include regulated expression of the alpha and beta (or gamma and delta) chains of the T cell receptor, expression of both CD4 and CD8 molecules (double positive stage), down regulation to a single positive stage (CD4 or CD8), as well as allowing those thymocytes to die which are unable to bind to self MHC molecules (death by neglect), selecting those thymocytes with T Cell Receptors that are able to bind to self MHC molecules with moderate affinity (positive selection), and deleting those thymocytes having T Cell Receptors that bind with high affinity to self MHC (negative selection), before allowing mature T cells to emigrate to the periphery.
C19318	Reproductive_Immunology	Reproductive_Biology	Reproductive Immunology|Reproduction Immunology	The science concerned with the various phenomena of immunity and induced sensitivity associated with the mother and fetus in gesticulating organisms.
C19319	Subcellular_Targeting_Experimental	Genetic_Engineering	Subcellular Targeting, Experimental	A molecular biology research technique whereby a protein is engineered to contain signals which will target it to a specific subcellular location.
C19320	Breast_Cancer_Model	Cancer_Model	Breast Cancer Model
C19321	Combinatorial_Synthesis	Techniques	Combinatorial Synthesis	Technique for making and testing many complex materials in parallel: computer guided synthesis in which all possible combinations are made. Combinatorial synthesis is not random, but systematic and repetitive, using sets of chemical "building blocks" to form a diverse set of molecular entities.  Initial synthesis is usually made on a solid substrate. The technique lays down the materials in a checkerboard arrangement, as thin squares arranged in a grid.  Scientists use combinatorial chemistry to create large populations of molecules, or libraries, that can be screened efficiently en masse.
C19322	Organic_Synthesis	Organic_Chemistry	Organic Synthesis	Branch of chemistry concerned with the synthesis of organic compounds.  It studies and develops schemes and reagents to synthesize specific classes of organics.
C19323	Tumor_Biology	Cancer_Biology	Tumor Biology	Biological differences between normal and cancer cells.  Studies use mechanistic approaches to explore tumor cell biology and tumor progression at the molecular and cellular level, and to examine cell-cell and cell-matrix interactions at the macromolecular level in whole tissues.  Included is the study of the pathology and biology of solid tumors and tumor-bearing animals, chimeric, transgenic, and knock-out animals.  Research focused on the development of technologies to facilitate these studies is included.
C19324	Supercomputing	High_Performance_Computing	Supercomputing	Pertaining to the fastest computers
C19325	RNA_Processing	Post-Transcriptional_Regulation	RNA Processing|RNA Metabolism: Processing and Transport	Modifications of primary RNA transcripts including: splicing, cleavage, base modification, capping and the addition of poly A (mRNA) or CCA (tRNA) tails. The primary transcript is the RNA molecule containing the exact sequence of bases (with U substituting for T in DNA) found in the nontemplate strand of transcribed DNA.
C19326	Clinics_and_Hospitals	Healthcare_Facility	Clinics and Hospitals|Clinics or Hospitals	Institutions with an organized medical staff for the medical care, treatment, and cure of the sick and wounded, for the study of disease, and for the training of physicians, nurses, and allied health personnel.
C19327	Endocrinology_Other	Endocrinology	Endocrinology, Other
C19328	Cooperative_Human_Tissue_Network	NCI_Consortium_or_Network	Cooperative Human Tissue Network|CHTN	Specializes in the prospective procurement, preservation and distribution of human tissues for research. Trained personnel coordinate the retrieval, preservation and delivery of specimens obtained from surgical resections and from autopsies.This resource provides normal, benign, pre-cancerous and cancerous human tissue to the scientific community for basic and developmental studies in many areas of cancer research.
C19329	NCI_Special_Emphasis_Panel	Component_of_the_Division_of_Extramural_Activities	NCI Special Emphasis Panel	Advises the Director, National Cancer Institute (NCI), and the Director, Division of Extramural Activities, regarding research grant and cooperative agreement applications, contract proposals and concept review relating to basic and clinical sciences, and applied research and development programs of special relevance to the National Cancer Institute.  Members and Chairs will be selected on an "as needed" basis in response to specific applications, proposals or proposed solicitations to be reviewed.  Established by the Director, NCI, September 29, 1995. Currently authorized under 42 U.S. Code 284 (c)(3), Section 405(c)(3) of the Public Health Service Act, as amended. The Panel is governed by the provisions of Public Law 92-463, as amended (5 U.S.C. Appendix 2).
C19330	NCI_Initial_Review_Group	Component_of_the_Division_of_Extramural_Activities	NCI Initial Review Group	An Initial Review Group reviews grant and cooperative agreement applications for centers, research projects, and research training activities in the areas of cancer cause, diagnosis, treatment, and prevention; and contract proposals relating to all facets of cancer.
C19331	Adenosine_Receptor	Purinergic-P1_Receptor	Adenosine Receptor	One of the purinergic P1 receptors that prefers adenosine to other endogenous purines.
C19332	Personal_Attribute	Properties_or_Attributes	Personal Attribute|Subject Characteristics
C19333	Intramural_Research_Award	Award|Research_Support	Intramural Research Award|IRA	The DCEG Intramural Research Award (IRA) is a new competitive funding mechanism to encourage exciting interdisciplinary projects that are innovative and cross the usual organizational boundaries. IRA recipients are recognized for their creative ideas and scientific skills in advancing the goals of the National Cancer Institute. Features of the IRA program include the following: Only Principal Investigators (PIs) are eligible to receive an IRA, although scientific collaborators may include non-PIs; Priority will be given to collaborative projects that are innovative and have potential for significant scientific or public health impact, including development of resources to facilitate population-based research (e.g., creation of a novel database or research model). Starting with FY1999 Pre-and Post-doctoral fellows became eligible for DCEG Intramural Research Awards.
C19334	Targeted_Research	Research_Funding_Categories	Targeted Research	Research funded as a result of an institute set aside of dollars for a specific scientific area. Institutes solicit applications using research initiatives (RFAs for grants, RFPs for contracts). Targeted research applications are reviewed by chartered peer review committees within institutes. The opposite of Investigator-initiated research.
C19335	Funding_Category	Funding	Funding Category	The specific subdivisions in a classification scheme of funding activities.
C19336	Head_and_Neck_Subset_of_Total	Costs	Head and Neck (Subset of Total)	A funding category.
C19337	Diagnostic_Ultrasound	Ultrasound_Imaging	Diagnostic Ultrasound|Diagnosis (US)|Diagnosis, Ultrasound	Use of ultrasound for imaging or diagnostic purposes. Employs frequencies ranging from 1.6 to 10 megahertz. (DCTD-DIP)
C19338	Magnetic_Resonance_Elastography	Magnetic_Resonance_Imaging|Magnetic_Resonance_Spectroscopic_Imaging	Magnetic Resonance Elastography	This imaging technique returns information about the mechanical properties (feel) of tissues by combining MRI with ultrasound.  A properly equipped MRI machine captures a cross sectional image of the sound waves, produced by ultrasound techniques, which are then processed by computer to produce an image showing the hardness or elasticity of tissues within the cross section.
C19339	Optical_Image_Reconstruction	Imaging_Technology	Optical Image Reconstruction|Image Reconstruction|Reconstruction	The process of generating an image from the raw data, or set of unprocessed measurements, made by an imaging system. (from AmershamHealth Medcyclopaedia)
C19340	Reflectance_or_Transmission_Spectroscopy	Spectroscopy	Reflectance or Transmission Spectroscopy	The spectroscopic analysis of light reflected from a polished sample.  The peaks of reflectance/transmittance occur in the same spectral region where the sample absorbs light.  In near infrared (IR) reflectance/transmission spectroscopy (NIRS), the reflectance signals result from bending and stretching vibrations in molecular bonds between carbon, nitrogen, hydrogen, and oxygen. (from FRTR Field Sampling and Analysis Technologies Reference Guide (online))
C19341	Multimodal_Imaging	Imaging_Technique	Multimodal Imaging|Multimodality	Simultaneous use of more than one imaging technique.
C19342	Digital_Photography	Imaging_Technology	Digital Photography|digital photography	A type of photography in which images can be viewed on a computer screen.
C19343	Other_Imaging_Modalities	Imaging_Technique	Other Imaging Modalities|Medical Imaging, Other	Imaging methods not listed.
C19344	Metabolic_Control	Metabolic_Process	Metabolic Control	Regulation of metabolic pathways
C19345	Chronic_Disorders_Nursing	Nursing	Chronic Disorders Nursing	Nursing care and research focused on populations with chronic disorders.
C19346	Culturing_in_vitro_Invertebrate	Tissue_Culture	Culturing, in vitro Invertebrate	Maintenance of invertebrate tissue after removal from the body, by placing in a vessel with a sterile nutritive medium.
C19347	Culturing_in_vitro_Microbial	Tissue_Culture	Culturing, in vitro Microbial	The growing of microbes in test tube or petri dish type environments
C19348	DNA_Replication_Damage	DNA_Damage	DNA Replication Damage|DNA Replicating Damage	DNA sequence errors introduced via DNA replication.
C19349	Electrical_Engineering	Engineering	Electrical Engineering	The application of engineering and mathematical principles to electrical problems
C19350	Nucleic_Acid_Biochemistry	Biochemistry	Nucleic Acid Biochemistry	The metabolism of nucleic acids and their components.
C19351	Nude_Mouse_Assay	Bioassay_in_vivo	Nude Mouse Assay	Any bioassay using a nude mouse.
C19352	Epidemiology_Descriptive	Epidemiology	Epidemiology, Descriptive	Population-based studies that describe trends and associations between risk factors, habits, and a specific chronic disease, such as cancer.
C19353	Tobacco_Use_Epidemiology	Epidemiology	Tobacco Use Epidemiology|Tobacco Epidemiology	Population-based research studies that assess associations between tobacco use, behavioral and biological factors, and cancer.  (NCI/TRIP)
C19354	Food_Assistance_Programs	Funding	Food Assistance Programs	Federal, state, or local programs that provide supplemental food assistance, e.g., Farmer's Market Coupon Program, Commodity Foods Program, Health Start; Women, Infant, & Children (WIC) Program. (NCI: 5 A Day Program)
C19355	Health_Communication	Patient_or_Public_Education	Health Communication
C19356	Virus-Cell_Membrane_Interaction	Viral_Function	Virus-Cell Membrane Interaction|Virus-Cell Interaction	A function, activity, or process involving the physical interaction between a virus or viral particle and a cell membrane. (NCI)
C19357	Cytotoxic_T-Lymphocyte_Analysis	Bioassay_in_vitro|Immunologic_Techniques	Cytotoxic T-Lymphocyte Analysis|CTL Analysis
C19358	Ubiquitination	Post-Translational_Modification	Ubiquitination|Ubiquitilation|Ubiquitinoylation	Ubiquitin is a family of widely distributed proteins found in all eukaryotes that contain a highly conserved sequence of 76 amino acids identical in organisms from humans to insects. It participates in diverse cellular functions by conjugation to other proteins through its carboxy terminus. Ubiquitination is associated with many highly regulated biological events including protein degradation, chromatin remodelling, heat shock, cell cycle progression, differentiation, antigen presentation, retrovirus assembly, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis. Protein ubiquitination regulates the half-lives of many proteins by targeting them for degradation. Newly discovered families of ubiquitination and deubiquitination enzymes participate in these processes. Ubiquitination enzymes may provide new therapeutic targets and ways of intervention in many human diseases.
C19359	DNA_Folding	Nucleic_Acid_Folding	DNA Folding	Energetics and biophysical mechanisms of DNA higher order structure
C19360	Dominant_Negative_Receptor	Receptor	Dominant Negative Receptor	A Dominant Negative Receptor inhibits the function of an associated protein, typically an alternate form of the same type receptor.
C19361	Tumor_Angiogenesis	Neovascularization	Tumor Angiogenesis	Proliferation of blood vessels in a tumor.
C19362	Electrophoretic_Mobility_Shift_Assay	Molecular_Biology_Techniques	Electrophoretic Mobility Shift Assay|Gel Shift Assay	A molecular biology technique used to detect the interaction of a DNA binding protein with its cognate binding sequence.  Labeled DNAs were reacted with crude cell extracts and the complexes are run through a non-denaturing polyacrylamide gel.  The migration of the labeled DNA through the gel will be slower by being bound.  This shift in electrophoretic mobility indicates functional binding between the protein and the DNA.
C19363	Electrospray_Ionization	Research_Techniques	Electrospray Ionization|ESI	A procedure used in mass spectrometry analysis. Means of delivering nonvolatile analytes into the gas phase for mass analysis. Best used on molecules which are charged in solution or readily accept a charge. Particularly well suited to the analysis of biomolecules. Can be used to probe tertiary structure and non-covalent interactions (from NCSU Mass Spectrometry Facility web site)
C19364	Health_Promotion_and_Education	Health_Education	Health Promotion and Education
C19365	Host-Tumor_Interaction	Immune_Response	Host-Tumor Interaction	The efforts by the host to reject a tumor, and the mechanisms by a tumor to evade recognition by the immune system.
C19366	Infection_Control_Nursing	Clinical_Nursing	Infection Control Nursing|Infectious Disease / Infection Control Nursing	A nursing specialty devoted to control and elimination of nosocomial infection risk in a clinical setting.  They do this through risk assessment, risk management, and staff education.
C19367	Information_and_Communication_Theory	Information_Sciences	Information and Communication Theory|Information and Communication	An interdisciplinary study dealing with the transmission of messages or signals, or the communication of information. Information theory does not directly deal with meaning or content, but with physical representations that have meaning or content. It overlaps considerably with communication theory and cybernetics.
C19368	Interfacial_Phenomena	Physical_Phenomena_or_Properties	Interfacial Phenomena	Phenomena originating at the interface of material
C19369	Learning	Mental_Process	Learning	The act, process, or experience of gaining knowledge or skill.
C19370	Marriage_and_Family	Socioeconomic_Factors	Marriage and Family	The social institution involving legal and/or religious sanction whereby men and women are joined together for the purpose of founding a family unit, which consists of parents and children.
C19371	Medical_Sciences_Clinical_Other	Clinical_Medicine	Medical Sciences, Clinical, Other
C19372	Molecular_and_Cellular_Biology	Molecular_Biology	Molecular and Cellular Biology
C19373	Natural_Products_Chemistry	Organic_Chemistry	Natural Products Chemistry
C19374	Pathway_Analysis	Research_Techniques	Pathway Analysis|Network Analysis	Elucidation of anabolic and catabolic pathways using labelled molecules or precursors. (NCI/OSP)
C19375	Neural_Development	Histogenesis	Neural Development|Neural Growth|Neurogenesis|Neuronal Growth	Neural Development involves proliferation, differentiation, and/or maturation of neural cells.
C19376	Neurological_Nursing	Nursing	Neurological Nursing|Neuroscience Nursing	Provide a high level of professional nursing care with a special emphasis on the care of individuals with neurological diseases/diagnoses, such as stroke (CVA), brain injury, or spinal injury.
C19377	Not_Defined	Business_Rules	Not Defined	No definition provided; unspecified.
C19378	Nuclear_Radiochemistry	Radiochemistry	Nuclear Radiochemistry
C19379	Nursing_Information_System	Computer_System	Nursing Information System
C19380	Retrovirology_Other	Retrovirology	Retrovirology, Other
C19381	Sensory_and_Communicative_Sciences_Other	Sensory_and_Communicative_Sciences	Sensory and Communicative Sciences, Other
C19382	Stress_and_Coping	Behavior	Stress and Coping	Use of conscious or unconscious strategies or mechanisms in adapting to stress (from PSY94)
C19383	Adjuvanticity	Attributes_of_Chemicals	Adjuvanticity	the ability to nonspecifically stimulate the immune response.
C19384	Admixture	Miscellaneous_Chemistry_Terms	Admixture	1. The act of mixing; mixture. 2. The compound formed by mixing different substances together.  3. That which is mixed with anything. (ARTFL Project: Webster Dictionary, 1913)
C19385	B-Cell_Proliferation	Cell_Proliferation	B Cell Proliferation	Growth and reproduction of B-lymphocytes.
C19386	B-Lymphoma_Development	Pathologic_Process	B-Lymphoma Development	Malignant transformation and proliferation of B lymphocytes. (NCI)
C19387	Cancer_Cell_Growth	Cancer_Progression	Cancer Cell Growth	The unregulated growth of cancer cells insofar as growth control and contact inhibition.
C19388	Cancer_Cell_Growth_Regulation	Pathologic_Process	Cancer Cell Growth Regulation	Control of the rate or manner of occurrence of the complex series of phenomena occurring after division and before death of cancer cells. (NCI)
C19389	Candidate_Disease_Gene	Gene	Candidate Disease Gene|Candidate Gene|Candidate Genes|Target Gene	A gene proposed to have a primary role in a disease, based upon its known function in other organisms or model systems or based upon its physical proximity to markers linked to a genetic disease.
C19390	Carcinogen_Metabolism	Detoxification	Carcinogen Metabolism	The sum of the chemical and physical changes occurring in tissue and resulting in biodegradation of any cancer-producing substance or organism.
C19391	Resistance	Resistance_Process	Resistance|resistance	Failure of a cancer to shrink after treatment.
C19392	Carcinogen_Resistance	Resistance	Carcinogen Resistance	The natural or acquired ability of an organism to maintain its immunity to or to resist the effects of a cancer causing agent.
C19393	Cell_Energetics	Biochemistry_and_Cellular_Biology	Cell Energetics	The study of the energy changes involved in physical and chemical reactions within a cell.
C19394	Cellular_Tropism	Cell_Growth_Process	Cellular Tropism	The directional growth of a cell toward or away from a stimulus.
C19395	Chromosome_Condensation	Cell_Division_Process	Chromosome Condensation	Chromosome Condensation is a process of progressive and tight packing of dispersed replicated interphase chromatin into compact visible nuclear genetic structures - chromosomes - in metaphase prior to mitotic or meiotic nuclear division in preparation for cell division, or during apoptosis in eukaryotic cells.
C19396	Equilibrium_Centrifugation	Centrifugation	Equilibrium Centrifugation|Fractionation, Centrifugation, Equilibrium	Centrifuge through a gradient until a substance reaches equilibrium
C19397	Chemical_Interference	DNA_Footprinting	Chemical Interference	A type of footprinting technique used to define the location of protein-nucleic acid contacts at the base pair level in nucleic acids.  It utilizes nucleic acids treated with a chemical in such a way that only a fraction of the nucleotides are chemically modified.  The chemically modified nucleotides that interfere with protein-nucleic acid complex formation can be identified by fragmentation and electrophoretic analysis of the DNA isolated from the complexes.
C19398	Complexes	Conceptual_Entities	Complex|Complexes	A structure formed by two or more dissimilar entities.
C19399	Computational_Chemistry_Statistics	Computational_Chemistry|Statistics	Computational Chemistry Statistics
C19400	Nucleotide_Biochemistry	Biochemistry	Nucleotide Biochemistry|Nucleotide / Nucleic Acid Chemistry
C19401	Nuclei_Structure_Function	Cell_Biology	Nuclei, Structure/Function
C19402	Disease_Association	Etiology	Disease Association
C19403	Nucleotide_Metabolism	Intermediary_Metabolism	Nucleotide Metabolism|Metabolism, Purines/Pyrimidines/Nucleotides/Nucleic Acids|Nucleotide Synthesis	Biosynthesis and catabolism of nucleic acids and their subunits
C19404	Mineral_and_Electrolyte_Metabolism	Intermediary_Metabolism	Metabolism, Minerals/Electrolytes	The incorporation of minerals and electrolytes in coenzymes and gradients.
C19405	Lipid-Lipoprotein-Membrane_Constituent_Metabolism	Intermediary_Metabolism	Lipid Metabolism|Metabolism, Lipids/Lipoproteins/Membrane Constituents	Biosynthesis and catabolism of lipids, lipoproteins, and other membrane constituents.
C19406	Amino_Acid-Peptide-Protein_Metabolism	Intermediary_Metabolism	Protein Metabolism	Biosynthesis and catabolism of proteins and their subunits
C19407	Docking	Molecular_Interaction	Docking	Molecular recognition, the analysis of protein-protein or protein-ligand interactions by computational (molecular modelling) techniques.  Of particular interest in the pharmaceutical industry for rational structure-based drug design.
C19408	Membrane_Structure_and_Function	Membrane_Biology	Membrane Structure and Function|Membranes, Structure/Function	The lipid bilayer structure of membranes, associated proteins and how it relates to the function.
C19409	DRB_Gene	MHC_Class-II_Gene	HLA-DRB1 Gene|DRB Gene|HLA-DRB1|Major Histocompatibility Complex, Class II, DR Beta 1 Gene	The class of genes that encode proteins of the major histocompatibility complex, class II, DR beta; HLA type II genes.
C19410	Membrane_Structure_Transport_Phenomena	Membrane_Structure_and_Function	Membrane Structure / Transport Phenomena
C19411	Drug_Efflux	Transport_Reaction	Drug Efflux	Transport of drugs out of a cell.  A mechanism of drug resistance.
C19412	Drug_Transport	Transport_Process	Drug Transport	Any subcellular or molecular event, process, or condition involved in translocation of a drug from one site or compartment to another. (NCI)
C19413	Eye_Development	Organogenesis	Eye Development	Human Eye Development involves bilateral outpouchings of optic vesicles, from the neural tube, that each form optic cups. By cell division, migration, differentiation, and synaptogenesis, the inner surface becomes the multi-layer neuroepithelial retina; the outer monolayer becomes the retinal pigment epithelium. Surface membranes cover the eye and develop into the lens, iris and cornea.
C19414	Nucleotide_Synthesis	Retired_Concepts	Nucleotide Synthesis
C19415	Nucleocytoplasmic_Transport	Intracellular_Transport	Nucleocytoplasmic Transport|Nucleocytoplasmic Shuttling	The transport of material in and out of the nucleus through the nuclear membrane.
C19416	G1-S_Restriction_Point	Cell_Cycle_Checkpoint	G1/S Restriction Point|G1-S Restriction Point	The point in G1 at which cells become committed to enter S phase and initiate DNA replication.
C19417	GATA-Binding_Protein	Sequence-Specific_DNA_Binding_Protein	Gata-Binding Protein	Sequence-specific DNA-binding proteins that recognize cis-elements with the core sequence GATA (or TATC).
C19418	Genetic_Algorithm	Computer_Software_Engineering	Genetic Programming|Genetic Algorithm	Genetic programing is a method for obtaining an optimal programming algorithm.  Thousands of randomly created programs are progressively evolved over time using an evolutionary search based on the principle of survival of the fittest.  Mechanisms include the equivalent of recombination, mutation, duplication, deletion, etc. (from http://www.genetic-programming.org)
C19419	Genotoxic_Stress	Cellular_Stress	Genotoxic Stress	Exposure to DNA-damaging agents and subsequent energy expenditures by a cell to repair DNA damage.  Genotoxic stress elicits biochemical responses that either enhance cell survival or lead to cell death. These biochemical responses include DNA-damage-inducible repair and increasing expression of a variety of proteins by both transcriptional and post-transcriptional mechanisms.  Genotoxic stresses frequently activate signal transduction pathways that originate in the cell membrane or cytoplasm, triggering similar phosphorylation cascades to those induced by the activation of cell-surface receptors.
C19420	N-Myristoylation	Post-Translational_Modification	N-Myristoylation	N-Myristoylation is the covalent attachment of myristic acid, a saturated 14-carbon fatty acid inserted in the cytoplasmic leaflet of the lipid bilayer, by an amide linkage to the amino-terminal glycine residue of a protein in order to increase the hydrophobicity of some membrane proteins or to promote membrane localization of some cytoplasmic proteins.
C19421	N-Myristoyltransferase-2	Acyltransferase	N-Myristoyltransferase 2|EC 2.3.1.97|Glycylpeptide N-Tetradecanoyltransferase 2|NMT2	Dioxins are potent mammalian carcinogens and toxins affecting liver, skin, and immune and reproductive systems. N-myristoyltransferase 2 (NMT2) is one of the later dioxin-inducible genes. NMT2 and induced protein myristoyltransferase activity are direct responses to carcinogen exposure. Because inappropriate protein NH(2)-terminal myristoylation appears to play a role in carcinogenesis, induction of NMT2 may play a central role in dioxin carcinogenicity. (from Cancer Res 2001;61:8534-9)
C19422	Sporadic_Breast_Tumor_Mutation	Somatic_Mutation	Sporadic Breast Tumor Mutation|Mutation in Sporadic Breast Tumor	A Sporadic Breast Tumor Mutation is a change in the DNA sequence of a breast tumor susceptibility gene that with reasonable probability could be considered not to have been passed down to its carrier through the maternal or paternal line.
C19423	Multiparametric_Analysis	Statistical_Methods	Multiparametric Analysis	The fitting of data to multivariable deterministic or statistical models; extraction of the number of independent parameters that contribute to the observable value of a function; the execution of an experimental test or procedure in which multiple parameters are monitored simultaneously.
C19424	mRNA_Export	RNA_Transport	mRNA Export	Transport of messenger RNA from its nuclear site of transcription to the cytoplasm, where the message is translated into protein by ribosomes.
C19425	Migration_Assays	Bioassay_in_vitro	Migration Assay|Cell Migration Assay|Migration Assays	An in vitro assay in which cultured cells are monitored and analyzed for their ability to move into an acellular area of a culture material.
C19426	Metal_Ion_Binding	Chelating_Activity	Metal Ion Binding	Reference to a chemical group or moiety that can complex or chelate a metal ion.
C19427	Hepatocarcinogenesis	Carcinogenesis	Hepatocarcinogenesis|Liver Carcinogenesis	The processes which result in cancers in the liver.
C19428	Metal_Carcinogenesis	Chemical_Carcinogenesis	Metal Carcinogenesis	The study of the processes by which normal cells are transformed into cancer cells by metals.
C19429	Membrane_Protein_Traffic	Subcellular_Protein_Targeting	Membrane Protein Traffic|Membrane Traffic|Membrane Traffic, Protein	Posttranslational modification of proteins targeted for membranes.
C19430	Membrane_Biology	Cell_Biology	Membrane Biology	The study of the protoplasmic boundary of all cells that controls permeability and may serve other functions through surface specializations; e.g., active ion transport absorption by formation of pinocytotic vesicles; receptor-mediated antigen recognition, etc.
C19431	Mammary_Tumorigenesis	Tumorigenesis	Mammary Tumorigenesis	Production of a new growth or growths in the mammary gland.
C19432	Histone-H2AX	Histone-H2A	Histone H2AX|H2A Histone Family, Member X|H2A.X|H2A/X|H2AFX|H2AX|H2AX Histone|Histone H2A.X	Encoded by human H2AX Gene (H2A Family) and expressed unlinked to replication in G1 and S-phase, 142-aa basal Histone H2AX has a unique conserved C-terminal sequence, QASQEY. NBS1/phospho-H2AX (gamma-H2AX) associate with irradiation-induced and V(D)J-induced DNA double-strand breaks. In pre-thymocytes, NBS1/gamma-H2AX form at RAG1-mediated TCRA V(D)J cleavage sites. NBS1/gamma-H2AX facilitate AID-dependent DNA break repair in G1 cells undergoing Ig heavy-chain constant region class switch recombination. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C19433	HL60	Tumor_Cell_Line	HL60|HL-60	HL-60 is a promyelocytic cell line derived by S.J. Collins, et al. Peripheral blood leukocytes were obtained by leukopheresis from a 36-year-old Caucasian female with acute promyelocytic leukemia. The cells resemble promyelocytes. In vitro the cells can be induced to differentiate terminally into granulocyte-like cells or monocyte/macrophage-like cells, depending on the inducing agent. This cell line has been used as a model for human myeloid cell differentiation.
C19434	HU_Protein	Bacterial_Protein	HU Protein	A DNA-binding and thermostable low-molecular-weight E. coli protein that resembles eukaryotic histones.  Acts as a cofactor in transcriptional repression. (from IRB summaries)
C19435	Human_Pathology	Pathology	Human Pathology	Branch of medicine concerned with the cause, origin, and nature of human disease, including the changes occurring as a result of disease. (from EPA Terminology Reference System)
C19436	Malignant_Conversion	Transformation	Malignant Conversion	The transformation of a cell or cell population from a pre- or non-malignant condition to a malignant condition. (NCI)
C19437	K-562	Tumor_Cell_Line	K-562|K562|K562 blasts	The continuous cell line K-562 was established by Lozzio and Lozzio from the pleural effusion of a 53-year-old female with chronic myelogenous leukemia in terminal blast crises. The K562 line is composed of undifferentiated blast cells that are rich in glycophorin and may be induced to produce fetal and embryonic hemoglobin in the presence of hemin.
C19438	Leukocyte_Trafficking	Cell_Migration	Leukocyte Trafficking	The circulation of white blood cells from the blood stream to tissues or secondary lymphoid organs, to the lymphatics, and back to the bloodstream via the thoracic duct.
C19439	Keratinocyte_Differentiation	Cell_Differentiation	Keratinocyte Differentiation	Differentiation of keratinocytes to the fully differentiated keratinocyte phenotype.
C19440	Volunteer_Group	Population_Group	Volunteer Group	Groups made up of volunteers.
C19441	Resource_Development	Research_Funding_Categories	Resource Development	Development of a new technology through the feasibility-testing stage to the level of a robust experimental or analytical tool. Development and maintenance of specialized specimen resources to facilitate basic and diagnostic cancer research, including tissue banks, tissue procurement, networks, and DNA banks.  Development of new tissue processing techniques and new reagents to better preserve critical molecular components to facilitate cancer diagnostic research.  Informatics support of tissue resources and diagnostic cancer research. (from Guide for Applicants: Genome Research Resource Grants (P41), Draft 1/24/95)
C19442	Media	Information_and_Media	Media|Communications Media|Forms of Communication|Medium	Any mechanism of mass communication.
C19443	Lung_Development	Organogenesis	Lung Development	For the lung, the act or process of natural progression in physical and physiological maturation from a previous, lower, or embryonic stage to a later, more complex, or adult stage.
C19444	Infectious_Disease_Immunology	Immunology	Infectious Disease Immunology|Bacterial/Viral/Mycotic Disease Immunology	Medical science dealing with the study of immunity to diseases caused by microorganisms such as bacteria, viruses, or fungi. (from PSY94)
C19445	Business_Commerce_Fiscal_Consultation	Business_Rules	Business / Commerce / Fiscal Consultation
C19446	Red_Blood_Cell_Structure_Function_Metabolism	Cell_Physiology	Red Blood Cell Structure/Function/Metabolism
C19447	Environmental_and_Occupational_Exposure	Exposure	Environmental and Occupational Exposure	The exposure to potentially harmful agents in the environment or to work-related environmental factors.
C19448	Blood_and_Blood_Products	Funding_Category	Blood and Blood Products	1A3; Basic Science Research (includes vaccine and chemotherapy development); Biomedical Research; Blood/Blood products (basic research and product development)
C19449	DNA_Modification_Process	Biochemical_Process	DNA Modification Process|DNA Modification	Biological processes that involve adding/removing chemical moieties to/from DNA, including methylation, phosphorylation, dephosphorylation, etc. occurring either in vivo or in vitro.
C19450	CAT_Gene	Reporter_Gene	CAT Gene|CAT|Chloramphenicol Acetyl Transferase Gene	Bacterial chloramphenicol-O-acetyltransferase (cat) gene encodes chloramphenicol-O-acetyltransferase protein, an enzyme that acetylates the antiobiotic chloramphenicol to yield chloramphenicol 3-acetate. This product is not an inhibitor of peptidyltransferase, the enzyme responsible for natural chloramphenicol resistance in bacteria. The cat gene is used to select chloramphenicol-resistant colonies following genetic transfection of bacteria.
C19451	Nucleic_Acid_Biochemistry_Enzymology	Nucleic_Acid_Biochemistry	Nucleic Acid Biochemistry, Enzymology	The branch of nucleic acid biochemistry concerned with the properties and actions of enzymes.
C19452	Psychiatry_Other	Psychiatry	Psychiatry, Other
C19453	Allogenicity	Physical_Phenomena_or_Properties	Allogenicity	A measure of the genetic difference between individuals or organisms.  It is a factor in determining if transplants are likely to succeed.
C19454	Toxicology_Other	Toxicology	Toxicology, Other	This term is used as a form filler when there is no appropriate Toxicology term available.
C19456	Miscellaneous_Chemistry_Terms	Chemistry	Miscellaneous Chemistry Terms
C19457	Vaccine_Development_Total	Funding_Category	Vaccine Development Total	Any aspect of vaccine research, development, testing, etc., for diseases other than AIDS. A vaccine must involve the administration of an antigen to induce an active and specific immune response. Induction of passive immunity does not constitute a vaccine although the term is sometimes misused for this process.
C19458	Scientific_Advances_and_Accomplishments	Business_Rules	Scientific Advances and Accomplishments|Advances and Accomplishments
C19459	Calendars	Document_Type	Calendar|Calendars
C19460	Specialized_Programs_of_Research_Excellence	Extramural_Funding_Mechanisms	Specialized Program of Research Excellence|Cancer Centers: SPORES|SPORE	The Specialized Programs of Research Excellence (SPOREs) established by NCI to promote interdisciplinary research and to speed the bi-directional exchange between basic and clinical science to move basic research finding from the laboratory to applied settings involving patients and populations. The goal of the SPORE program is to bring to clinical care settings novel ideas that have the potential to reduce cancer incidence and mortality, improve survival, and to improve the quality of life. SPOREs are funded through specialized center grants (P50s).
C19461	Contractor	Miscellaneous_Occupations	Contractor	Non-Fed. Govt companies who contract to do specific work for the Fed Govt thru the official Contracting process.
C19462	Educational_Materials	Document_Type	Educational Materials	Document type: Materials intended to educate the lay public in all aspects of cancer information
C19463	Employment_Opportunities	Business_Rules	Employment Opportunities	Jobs available at NCI
C19464	Form	Document_Type	Form	A printed or electronic document with spaces to be filled out.
C19465	Funding_Applicant	Funding	Funding Applicant	Someone applying for financial support from NCI to do research, training, or other work
C19466	Gifts_and_Donations	Funding	Gifts and Donations
C19467	Home_Page	Document_Type	Home Page	The introductory page of a website; its navigational starting point.
C19468	Industry_Collaboration	Business_Rules	Industry Collaboration	Collaboration by NCI with industry (usually pharmaceutical) for cancer research
C19469	Industry_Collaborators	Business_Rules	Industry Collaborators
C19470	Links_List	List	Links List|Hyperlink|Link	Hyperlinks in documents.
C19471	Research_Project_Summaries	Document_Type	Research Project Summaries	Document type
C19472	Rapid_Access_to_Intervention_Development	Grants_and_Contracts_NIH	Rapid Access to Intervention Development|RAID|Rapid Access to Intervention Development Program|Rapid Access to Intervention Development Program (RAID)	RAID is a new program designed to facilitate translation to the clinic of novel, scientifically meritorious therapeutic interventions originating in the academic community. It will do this by making available to the academic research community, on a competitive basis, NCI resources for the pre-clinical development of drugs and biologics.
C19473	Recently_Cleared_Concept	Program_Announcements	Recently Cleared Concept	Document type (funding opportunity): a PA or RFA not requiring clearance at the NCI Board of Scientific Advisors
C19474	Program_Review_Group_Report	Report	Program Review Group Report	Document type: a report from a Program Review Group to the NCI Director.
C19475	Grant_Review_Process	Business_Rules	Grant Review Process	Official process of peer review for federal grants
C19476	Spanish-Language_Documents	Document_Type	Spanish-Language Document	Document type
C19477	Medical_Image	Image	Medical Image|Image	Any record of a medical imaging event whether physical or electronic.
C19478	G-Banding	Chromosome_Banding	G-Banding	Use of Giemsa stain to produce a characteristic staining pattern on chromosomes
C19479	R-Banding	Chromosome_Banding	R-Banding	Using acridine orange, this technique produces a chromosomal staining pattern which is the reverse of G-banding.
C19480	Culturing_in_vitro_Vertebrate_Tissue	Tissue_Culture	Culturing, in vitro Vertebrate, Tissue	Maintenance of vertebrate tissue after removal from the body, by placing in a vessel with a sterile nutritive medium.
C19481	Culturing_in_vitro_Vertebrate_Cell	Cell_Culture	Culturing, in vitro Vertebrate, Cell	Propagation of vertebrate animal cells in culture.
C19482	Certificate_of_Confidentiality	Document_Type	Certificate of Confidentiality	Protects researchers from involuntary disclosure of personal identifying information acquired in the course of a research project.  Data cannot be subpoenaed and assures anonymity to study participants.  NCI can issue a certificate.
C19483	Expanded_Authorities	Business_Rules	Expanded Authorities	The operating authorities provided to grantees under certain research grant mechanisms that waive the requirement for NIH prior approval for specific actions i.e., change budget categories amounts.
C19484	Facilities_and_Administrative_Costs	Costs	Facilities and Administrative Costs|F and A|Facilities and Administrative Costs (F and A)|Indirect Costs	Costs that are incurred for common or joint expenses at an institution by grant or contract activities which cannot be specifically identified with a particular user.  Expressed as a percentage. (formerly known as indirect costs)
C19485	Green_Card	Document_Type	Green Card|Alien Registration Receipt Card I-55	A card issued by the U.S. Immigration Service verifying that the person has been granted status as a permanent resident of the United States and is eligible to receive a training or career award (Alien Registration Receipt Card I-55).
C19486	Institution_Supplementation	Funding	Institution Supplementation	Additional support to assist in meeting living costs may be provided by the grantee training institution.  This supplement does not require any additional effort from the trainee.  Federal funds may not be normally used except by special arrangements and authorization.  There are no restrictions on use of private funds.
C19487	Institutional_Animal_Care_and_Use_Committee	Professional_Organization_or_Group	Institutional Animal Care and Use Committee|IACUC
C19488	Just-in-time-concept	Grants_and_Contracts_Operations	Just-in-time-concept|JIT|Just-In-Time	Proposes the submission of budget information that once was included in all competing applications initially now submitted at a time when there is a certainty of an award.  It is anticipated this change will reduce the administrative burden for the applicants, their institutions and the reviewers of the application.
C19489	Mentor_s_Statement	Document_Type	Mentor's Statement	A description of the kind and extent of supervision, guidance and advice that the mentor intends to contribute to the trainee during the proposed award period.
C19490	Non-Citizen_National	Minority_Group	Non-Citizen National	Persons who are not U.S. citizens but who owe permanent allegiance to the U.S.  They originate from places under U.S. sovereignty, jurisdiction, or administration, i.e. American Samoa, Swains Island.
C19491	Population_Sciences	Occupation_or_Discipline	Population Sciences	As defined by various Divisions within the NCI they include: Epidemiology, Nutrition, Behavioral Medicine, Genetics, Public Health, Anthropology, Tobacco Control Research, Demography, Bioethics, Sociology.
C19492	Professional_Degree_Clinically_Equivalent	Training_and_Education	Professional Degree (Clinically Equivalent)	Individual usually trained for clinical work.  Includes M.D., D.D.S., D.M.D., DVM, D.O., D,C., N.D., Pharm. D, R.N. with Doctorate, (contrast  to an academic degree).
C19493	Reapplication	Grants_and_Contracts_Operations	Reapplication	The National Institutes of Health will consider only two amendments to the initial grant application.  Regardless of the number of amendments, the NIH will not accept a revised (amended) application that is submitted later than two years beyond the date the initial application was received.
C19494	NCI_Scholars_Program	Career_Transition_Award	NCI Scholars Program|Scholars Program
C19495	Senior_Scientist	Research_Personnel	Senior Scientist	A person who is at least seven years beyond their doctoral award.
C19496	Transition_Career_Development_Award	Career_Transition_Award	Transition Career Development Award (K22)|Transition Career Development Award	The purpose of the NCI Transition Career Development Award (K22) is to provide "protected time" for newly independent investigators to develop and receive support for their initial cancer research programs.  This award is intended to facilitate the transition of investigators from the mentored to the independent stage of their careers in cancer research.  It applies to clinicians who are pursuing basic science careers; clinicians who are pursuing careers in patient-oriented research; and to individuals pursuing careers in the prevention, control and population sciences.
C19497	National_Research_Service_Award_for_Senior_Fellows	Fellowship_Programs_F-Series|Individual_National_Research_Service_Award	National Research Service Award for Senior Fellows|F33 Award|Senior Fellowships (F33)|Senior Scholarship Award|Senior Scholarship Award (F33)
C19498	Document_Type	NCI_Administrative_Concepts	Document|Document Type	A writing that contains information; used here to represent any thing that is categorized by writing.
C19499	DNA_Biochemistry	Nucleic_Acid_Biochemistry	DNA Biochemistry|Nucleic Acid Biochemistry, DNA|Nucleic Acid Biochemistry, DNA - Deoxyribonucleic Acid
C19500	RNA_Biochemistry	Nucleic_Acid_Biochemistry	RNA Biochemistry|Nucleic Acid Biochemistry, RNA|Nucleic Acid Biochemistry, RNA - Ribonucleic Acid
C19501	Tumorigenicity	Biological_Effect_of_Chemicals	Tumorigenicity	A measurement of the tumor-producing/cancer cell-producing potency of an agent. The carcinogenicity value is usually expressed as milligrams of agent administered per tumor developed.
C19502	Gender_Minority_Enrollment	Education_and_Outreach	Gender/Minority Enrollment	Outreach programs for the recruitment of women and members of minority groups as subjects in projects of clinical research. (from NIH Guidelines on the Inclusion of Women and Minorities as Subjects in Clinical Research)
C19503	Underserved_Rural_Health	Funding_Category	Underserved, Rural Health|Underserved (Includes Rural Health)	This includes rural, elderly, low-literacy, blue collar, and poor populations. Minorities per se are not included but often belong to one or more or the included categories.
C19504	Herpes_Total	Funding_Category	Herpes, Total	A funding category that should include all grants having to do with herpes research.
C19505	Cancer_Centers-Subcommittee_A	NCI_Initial_Review_Group	Cancer Centers-Subcommittee A
C19506	Basic_and_Preclinical-Subcommittee_C	NCI_Initial_Review_Group	Basic and Preclinical-Subcommittee C
C19507	Clinical_Studies-Subcommittee_D	NCI_Initial_Review_Group	Clinical Studies-Subcommittee D
C19508	Prevention_and_Control-Subcommittee_E	NCI_Initial_Review_Group	Prevention and Control-Subcommittee E
C19509	Manpower_and_Training-Subcommittee_F	NCI_Initial_Review_Group	Manpower and Training-Subcommittee F
C19510	Education-Subcommittee_G	NCI_Initial_Review_Group	Education-Subcommittee G
C19511	Clinical_Groups-Subcommittee_H	NCI_Initial_Review_Group	Clinical Groups-Subcommittee H
C19512	Terminated_Comprehensiveness-Subcommittee_B	NCI_Initial_Review_Group	Comprehensiveness Subcommittee B|Comprehensiveness-Subcommittee B	An Initial Review Group that was terminated in June 1996.
C19513	NCI_Director_s_Working_Groups	Advisory_Committee_to_the_NCI_Director	NCI Director's Working Groups
C19514	Program_Review_Groups	NCI_Advisory_Boards_and_Groups	Program Review Group|Program Review Groups	The Program Review Groups function to examine the NCI extramural programs and their infrastructures to evaluate whether changes are necessary in order for the Institute to be in a position to effectively guide and administer the needs of the science in the foreseeable future. (http://deainfo.nci.nih.gov/advisory/bsa/bsa_program/pogprogramfo.htm)
C19515	Breast_Cancer_Progress_Review_Group	Progress_Review_Group	Breast Cancer Progress Review Group	The Breast Cancer Progress Review Group will work with NCI staff in conducting an in-depth evaluation of the current state-of-knowledge regarding this area, survey the literature and related fields of science, and recommend to the NCI, through the National Cancer Advisory Board and the Board of Scientific Advisors, how the Institute can optimally respond to and stimulate research opportunities related to breast cancer including the improvement in detection technologies. This exercise will help set the NCI's research agenda in breast cancer by identifying and prioritizing those scientific opportunities that are most likely to expand our knowledge base and that will ultimately reduce the burden of this cancer.
C19516	Prostate_Cancer_Progress_Review_Group	Progress_Review_Group	Prostate Cancer Progress Review Group
C19517	Other_Working_Groups	NCI_Advisory_Boards_and_Groups	Other Working Groups
C19518	AIDS-Related_Malignancies_Working_Group	Other_Working_Groups	AIDS-Related Malignancies Working Group	Function: Provide a national scientific forum to identify research opportunities and to provide recommendations on research priorities, resource needs, and how best to address them across the range of issues in AIDS-related malignancies.
C19519	Contingency_Fund	Business_Rules	Contingency Fund
C19520	Early_Detection_Branch	Division_of_Cancer_Prevention	Early Detection Branch	Development of scientific information and concepts, and dissemination of knowledge regarding early detection techniques, practices, and strategies to reduce mortality and morbidity from cancer.  The program supports clinical trials and other appropriate research, fosters technological development, and encourages the publication of scientific findings and adoption of early detection practices.
C19521	Cancer_Genetics_Working_Group	NCI_Director_s_Working_Groups	Cancer Genetics Working Group
C19522	Developmental_Diagnostics_Working_Group	NCI_Director_s_Working_Groups	Developmental Diagnostics Working Group	Mission and Organization: To identify broad scientific opportunities that would enable the National Cancer Institute to develop tests that will allow treatment choice to be based on the fundamental properties of a tumor cell. (from http://deainfo.nci.nih.gov/advisory/pog/directors/dev_diag/devdiagfo.htm)
C19523	Preclinical_Models_for_Human_Cancers_Working_Group	NCI_Director_s_Working_Groups	Preclinical Models for Human Cancers Working Group
C19524	Imaging_Sciences_Working_Group	NCI_Director_s_Working_Groups	Imaging Sciences Working Group
C19525	Developmental_Therapeutics_Program_Review_Group	Program_Review_Groups	Developmental Therapeutics Program Review Group
C19526	Cancer_Centers_Program_Review_Group	Program_Review_Groups	Cancer Centers Program Review Group
C19527	Cancer_Control_Program_Review_Group	Program_Review_Groups	Cancer Control Program Review Group
C19528	Clinical_Trials_Program_Review_Group	Program_Review_Groups	Clinical Trials Program Review Group
C19529	Prevention_Program_Review_Groups	Program_Review_Groups	Prevention Program Review Groups
C19530	Sequence-Specific_DNA_Binding_Protein	DNA_Binding_Protein	Sequence-Specific DNA Binding Protein	A class of proteins that bind DNA but require the presence of specific string of bases.
C19531	JUN_Gene	JUN_Family_Gene	JUN Gene|c-JUN Gene|v-JUN Sarcoma Virus 17 Oncogene Homolog (Avian) Gene	The serum-induced human c-JUN Gene (JUN family) at 1p32-p31 lacks introns and encodes dimeric JUN Protein DNA-binding transcription factors involved in growth-related transcriptional control.  JUN appears to exhibit three distinct functions: dimerization (by a leucine zipper with c-FOS) to form the enhancer-binding protein AP1, TGA(C/G)TCA DNA-binding, and transcriptional activation (enhanced by phosphorylation).  JUN exhibits structural and functional similarity with yeast transcription factor GCN4; both have a DNA-binding domain on the carboxyl end.  JUN also appears to interact with SMAD3/SMAD4 transcription factor heterodimers.  (from SWISS-PROT, OMIM, and NCI)
C19532	FOS_Gene	FOS_Family_Gene	FOS Gene|FOS|G0S7|Protooncogene FOS|c-FOS Gene|v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog Gene	The 4 kb human FOS Gene (FOS family) at 14q24.3 contains three introns and sequence homologous to Finkel-Biskis-Jinkins murine osteosarcoma virus.  FOS encodes a DNA-binding c-FOS phosphoprotein that dimerizes with JUN family members via a bZIP motif to form AP1 transcription factor, important in signal transduction, cell proliferation, and differentiation.  Diverse stimuli increase FOS expression: growth factors, cytokines, polypeptide hormones, neurotransmitters, stress, and cell injury.  FOS regulates osteoclast-macrophage lineage determination and neuronal cell survival.  FOS expression is induced by neuronal activity; elements in the FOS promoter mediate NGF induction.  FOS may transform cells through alterations in DNA methylation and histone deacetylation.  (from SWISS-PROT, OMIM, and NCI)
C19533	Vertebrate_Biology	Zoology	Vertebrate Biology	A biological science concerned with the origin, structure, development, growth, function, genetics, and reproduction of animals having a vertebral column.
C19534	Recombination_Repair	Double_Strand_Break_Repair	Recombination Repair|Homologous Recombinational Repair|Recombinational Repair	Homologous recombination can operate at both double-strand breaks and free ends. The homologous chromosome serves as a template for DNA repair during recombination.
C19535	UV_Systematic_Effects	Radiation_Biology	UV, Systematic Effects
C19536	Metabolic_Process	Biochemical_Process	Metabolic Process|Metabolic Process, Cellular|Metabolism	Organic processes in a cell or organism that are necessary to sustain life. Cellular metabolism can be divided into two categories. Anabolism entails the construction of complex organic molecules from simpler precursors, while catabolism involves the breakdown of complex substances into simpler molecules.
C19537	High_Prevalence	Prevalence	High Prevalence
C19538	Training_and_Infrastructure	Research_Infrastructure	Training and Infrastructure
C19539	Radiotherapy_Medical_Specialty	Medical_Specialty	Radiotherapy [Medical Specialty]	The medical specialty concerned with the use of electromagnetic or particulate radiation in the treatment of disease.
C19540	Cancer_Gene	Gene	Cancer Gene|Cancer-Promoting Gene	Normal genes, that when altered or inappropriately expressed, contribute to malignant transformation, tumor progression, or metastasis.
C19541	Compact_Disc-Interactive	Storage_Medium	Compact Disc-Interactive|CD-I|CDI|CDI (Compact Disc-Interactive)|Interactive CD	An optical disk that is physically the same as an audio CD, but contains multimedia information (images, sound, etc.) The user can interact with films, games and educational programs. (computeruser.com)
C19542	Desktop_Video	Media	Desktop Video|Desk Video
C19543	Digital_Video-Interactive	Media	Digital Video-Interactive|DVI|DVI (Digital Video Interactive)
C19544	Integrated_Learning_System	Computer_System	Integrated Learning System|ILS|Integrated Learning System (ILS)	A computer system that provides tutorial instruction in academic subjects at an individual level in a format that allows students to master material at their own pace, i.e., CME courses.
C19545	Interactive_Communication	Information_and_Communication_Theory	Interactive Communication
C19546	Palmtop	Computers	Palmtop|Hand-Held Computer	A small computer that literally fits in the palm. Used as personal organisers, to store names and addresses, play games, access the Internet,etc.
C19547	Smart_Card	Diagnostic_Therapeutic_and_Research_Equipment	Smart Card	Credit card-sized memory card that stores software applications and modem capabilities and that can be inserted in palmtop and laptop computers.
C19548	Z-DNA_Binding_Protein	DNA_Binding_Protein	Z-DNA Binding Protein	A protein which specifically binds to Z DNA
C19549	Education_of_Caregivers	Health_Education	Education of Caregivers
C19550	Alpha_Particle_Emitter	Physical_Phenomena_or_Properties	Alpha Particle Emitter	unstable isotopes of high atomic number (elements of mass number from 82 up) which energetically release from their nuclei a particle consisting of two neutrons and two protons, with a positive charge (2e+) and identical to the helium nucleus.
C19551	Epidemiology_of_Childhood_Malignancies	Cancer_Epidemiology	Epidemiology of Childhood Malignancies	A subdiscipline of epidemiology focusing on determination of causes and incidence of malignancies in children.
C19552	Prediction_of_Radiation_Response	Prediction_of_Response_to_Therapy	Prediction of Radiation Response
C19553	Baculovirus_Expression_System	Expression_Technologies_for_DNA_and_RNA	Baculovirus Expression System	An insect cell-infecting virus that is used extensively in expression systems for recombinant proteins that require eucaryotic processing systems.
C19554	HIV-1_Load	Personal_Attribute	HIV-1 Load	The measure of circulating viral particles in an HIV infected individual.  Used as a prognostic indicator of disease progression.
C19555	Microtubule_Depolymerization	Microtubule_Alteration	Microtubule Depolymerization	Microtubule depolymerization is a cellular process typically, though not solely, involved in cell motility and cell division.  Induction of microtubule depolymerization causes interruption of mitosis and is the mode of action of several antineoplastic agents.
C19556	Microtubule_Polymerization	Microtubule_Alteration	Microtubule Polymerization	Microtubule polymerization is a cellular process typically, though not solely, involved in cell motility and cell division.  Stabilization of microtubule polymerization causes interruption of mitosis and is the mode of action of several antineoplastic agents.
C19557	Tumor_Oxygenation	Tumor-Associated_Process	Tumor Oxygenation	Level of oxygen saturation within a tumor. Increase in the oxygenation of a tumor acts as a radiosensitizer.
C19558	Cocrystallography	Crystallography	Cocrystallography|Cocrystallization	A protein crystallographic technique, which utilizes a unique quality filter to create crystal structures which show both the target protein fold and the part of the scaffold that binds to it. The technique is used for scaffold-based drug design.
C19559	Cell_Cycle_Arrest	Cell_Cycle_Inhibition	Cell Cycle Arrest	An interruption in the periodic biochemical and structural events occurring during proliferation of cells such as in tissue culture; the cycle is divided into periods called: G0, Gap1 (G1), synthesis (S1), Gap2 (G2), and mitosis (M). The period runs from one division to the next.
C19560	Cell_Ontogeny	Cell_Lineage	Cell Ontogeny	Development of the individual cell, as distinguished from phylogeny, which is evolutionary development of the species.
C19561	Sister_Chromatid_Exchange_Assay	DNA_Analysis	Sister Chromatid Exchange Assay|SCE Assay	Measures sister chromatid exchange, usually by autoradiography.  Increased sister chromatid exchange is correlated with exposure to mutagenic or genotoxic stimuli.
C19562	Nuclear_Transfer	Cytological_Techniques	Nuclear Transfer	Transfer of a nucleus from one cell to another.
C19563	Tissue-Specific_Gene_Expression	Gene_Expression	Tissue-Specific Gene Expression|Differential Gene Expression|Tissue-Specific Differential Gene Expression	Expression of different genes in different tissues.
C19564	Tissue-Specific_Splicing	Alternate_Splicing	Tissue-Specific Splicing	Alternate splicing which is specific and typical for a given tissue.
C19565	Whole-Body_Scintigraphy	Scanning_Procedure_or_Technique	Whole-Body Scintigraphy
C19566	Ectopic_Expression	Gene_Expression	Ectopic Expression	Expression in an abnormal part of the body
C19567	Isozyme	Miscellaneous_Molecular_Biology_Terms	Isozyme|Isoenzyme	The term "isoenzyme" or "isozyme" refers to variants of the same enzyme which can be separated on special conducting media using electrophoresis. It should apply only to those multiple forms of enzymes arising from genetically determined differences in primary structure and not to those derived by modification of the same primary sequence.
C19568	Viral_Function	Biological_Process	Viral Function|Viral Activity	Biological functions, activities, or processes of viral elements that support the viability, propagation, or maintenance of a virus. (NCI)
C19569	Virus-Induced_Membrane_Fusion	Membrane_Fusion_Activity	Virus-Induced Membrane Fusion	Virus-Induced Membrane Fusion involves merging of an envelope type virus particle with a cellular lipid bilayer membrane, often occurring in the course of viral cell infection.
C19570	Membrane_Fusion_Activity	Virus-Cell_Membrane_Interaction	Membrane Fusion Activity	Membrane Fusion Activity involves merging of adjacent structures delimited by lipid bilayer membranes into a single structure.
C19571	Molecular_Toxicology	Toxicology	Molecular Toxicology
C19572	Bistrand_Abasic_Site	DNA_Structure	Bistrand Abasic Site	Location on a DNA strand where the phosphate backbone is intact but the nitrogenous base has been lost from boths DNA strands.
C19573	Fiber_FISH	Fluorescence_in_situ_Hybridization	Fiber FISH	Fluorescent in situ hybridization performed on uncondensed DNA strands.  Due to the extended nature of the target DNA this technique provides greater sensitivity for mapping closely situated markers.
C19574	GIS_Imaging	Imaging_Technology	GIS Imaging|Geographic Information System Imaging
C19575	Random_Peptide_Synthesis	Peptide_Synthesis	Random Peptide Synthesis	Generation of peptide libraries by random use of all 20 amino acids.(NCI2005)
C19576	Nutritional_Carcinogenesis	Carcinogenesis_Mechanism	Nutritional Carcinogenesis	Basic studies on the etiologic effects of dietary macronutrients such as fat, vitamins and proteins; food mutagens and carcinogens formed during cooking; carcinogenic compounds and other substances closely associated with food preparation such as free radicals, fibers, and pyrolysis products; and digestive tract mutagens which form as a result of compound biodegradation, biotransformation, etc. The etiology of cancer resulting from deficiencies in the availability of various micronutrients, vitamins, metals, etc., is also of interest.
C19577	Multidimensional_NMR_Techniques	Magnetic_Resonance_Imaging|Magnetic_Resonance_Spectroscopic_Imaging|Magnetic_Resonance_Spectroscopy	Multidimensional NMR Techniques	Various NMR methods that can be used to determine 3D structures of macromolecules.
C19578	Lytic_Phase	Viral_Function	Lytic Phase|Lytic Cycle|Lytic Infection	A phase of the virus life cycle during which the virus replicates within the host cell, releasing a new generation of viruses when the infected cell lyses. (NCI)
C19579	Direct_Costs	Costs	Direct Costs	Costs that can be identified with a particular project or program. Allowable direct costs may include salaries and fringe benefits of principal investigators and supporting staff, expenditures for project-related equipment and supplies, fees and supporting costs for consultant services, expenses for travel, inpatient and outpatient costs for research subjects, publications and other miscellaneous expenses, contract services, and costs for consortium participants.
C19580	Protein_Phosphatase_2A	Retired_Concepts	Protein Phosphatase 2A|PP2A
C19581	Restriction_Enzyme_Analysis	DNA_Analysis	Restriction Enzyme Analysis	Use of restriction endonucleases to analyze and generate a physical map of genomes or genes.
C19582	Run-On_Assays	RNA_Analysis	Run-On Assays	A method to determine the constellation of sequences being actively transcribed at a given moment.  Cell nuclei are harvested, and then supplied with a pulse of radioactive nucleotides.  Transcription is allowed to proceed to an end, but additional initiations are inhibited.  RNAs are then extracted and separated by gel electrophoresis.
C19583	Embryonic_Lethal_Mutation	Gene_Mutation	Embryonic Lethal Mutation	A mutation that leads to death of a fetus or embryo prior to birth.
C19584	Rat-1	Rat_Cell_Line	Rat-1|Rat-1 Cells	Fibroblasts used as an in vitro model for cell signaling studies
C19585	DNA-Mediated_Gene_Transfer	Gene_Transfer	DNA-Mediated Gene Transfer	Introduction of naked DNA into cells by various methods.
C19586	Liposome-Mediated_Gene_Transfer	Gene_Transfer	Liposome-Mediated Gene Transfer	Encapsulation of DNA within a lipid bilayer with subsequent introduction into a cell by fusion of the liposome with the cell membrane.
C19587	Antibody_Repertoire	Miscellaneous_Molecular_Biology_Terms	Antibody Repertoire
C19588	Atomic_Resolution_X-Ray_Crystallography	X-Ray_Crystallography	Atomic Resolution X-Ray Crystallography	Atomic resolution crystallography (< 1.2 Angstrom) is a powerful tool in crystallography for the elucidation of protein structure. X-rays are passed through crystals and the subsequent diffraction pattern is analyzed.  The position of the atoms can be reconstructed using computerized analysis of the diffraction pattern. The atomic positions are accurately defined and fine details in the electron density become visible, which reveal small but significant structural changes.
C19589	Viral_Pathogenesis	Pathogenesis	Viral Pathogenesis	A disease state resulting from virus infection.
C19590	Whole_Genome_PCR	Polymerase_Chain_Reaction	Whole Genome PCR	The application of PCR amplification to the isolation of gene regulatory elements present in the genome, without the use of gene-specific primers.  The selection step is accomplished by sequence-specific DNA binding to a particular protein, followed by immunoprecipitation.  Multiple cycles of immunoprecipitation and amplification are used to enrich for the DNA sequence of interest.
C19591	Diagnostic_Factor	Diagnostic_or_Prognostic_Factor	Diagnostic Factor|Diagnostic Marker	A biological, physiological, behavioral, or molecular indicator of the presence or predisposition towards development of a specific disease.
C19592	Direct_Cost_Greater_Than_500K_Per_Year	Direct_Costs	Direct Cost Greater Than 500K Per Year
C19593	Gender_Minority_Projection	Business_Rules	Gender/Minority Projection	An estimate of the percent of each sex will exits for a minority.
C19594	Not_Otherwise_Specified	Business_Rules	Not Otherwise Specified	Not characterized in any other way.
C19595	Nutritional_Epidemiology	Epidemiology	Nutritional Epidemiology	Study of the effects of nutrition on disease incidence and outbreaks.
C19596	Occupational_Environmental_Epidemiology	Epidemiology	Occupational/Environmental Epidemiology
C19597	Tissue_Paraffin	Tissue_Sample	Tissue, Paraffin	Tissue that is preserved and embedded in paraffin
C19598	Cell_Cycle_Regulation	Cell_Proliferation_Regulation	Cell Cycle Regulation|Cell Cycle Control|Cell Cycle Regulation, Including Apoptosis	Control of the rate or manner of the periodic biochemical and structural events occurring during proliferation of cells; the cycle is divided into periods called: G0, Gap1 (G1), synthesis (S1), Gap2 (G2), and mitosis (M). The period runs from one division to the next.
C19599	T-Cell_Proliferation	Cell_Proliferation	T-Cell Proliferation	An increase in the number of all, or specific subsets of, T-cells by cell growth and cell division during an immune response or during development.
C19600	Replication_Error	DNA_Replication_Damage	Replication Error|RER	A Replication Error results from the covalent addition of an incorrect nucleotide subunit, or the lack of addition of a nucleotide subunit, during polymerization of the growing newly synthesized DNA strand during replication. (NCI)
C19601	Breast_Cancer_Prognostic_Factor	Prognostic_Factor	Breast Cancer Prognostic Factor	A situation, condition, or a characteristic of a patient that can be used to estimate the chance of recovery from breast cancer or the chance of recurrence of breast cancer.
C19602	Board_Certification	Training_and_Education	Board Certification	Licensing by a governing group to a physician to practice in a particular field of medicine.
C19603	American_College_of_Radiology_Imaging_Network	Clinical_Trials_Cooperative_Group	American College of Radiology Imaging Network|ACRIN	An infrastructure for multi-institutional clinical trials of imaging and related disciplines applied to cancer. The group has been in operation since March 1999. It does not have a continuing membership.
C19604	Office_of_Technology_and_Industrial_Relations	Component_of_the_Office_of_the_Director	Office of Technology and Industrial Relations
C19605	Biochemistry_and_Cellular_Biology	Cell_Biology	Biochemistry and Cellular Biology	The chemistry of living organisms and of the chemical, molecular, and physical changes occurring therein, pertaining the the cell.
C19606	Biology_of_HIV_Transmission	Virology_and_Immunopathogenesis_of_HIV	Biology of HIV Transmission	Delineate the mechanisms of transmission and population spread of infection and their impact on disease progression.
C19607	Comparative_Carcinogenesis	Carcinogenesis_Mechanism	Comparative Carcinogenesis	The study of the similarities and differences between different living organisms of the process by which normal cells are transformed into cancer cells.
C19608	Double_Strand_Break_Repair	DNA_Repair	Double Strand Break Repair|Double-Strand Break Repair	Mechanisms of DNA repair associated with radiation damage.
C19609	Functional_Imaging	Imaging_Technique	Functional Imaging|Physiologic Imaging	The visualization of physiological, cellular or molecular processes in living tissue in real time as they take place in cells, for example, blood flow, oxygen consumption or glucose metabolism. (Bypass Budget)
C19610	Immunodeficiency_and_Cancer	Cancer_Etiology	Immunodeficiency and Cancer	Investigations into the relationship between immune function and cancer.  Immunodeficient individuals are less able to mount an attack on cancerous cells.
C19611	Molecular_Immunology	Immunology	Molecular Immunology|Immunology, Molecular	Sub-discipline of immunology which investigates the molecular interaction involved in antigen recognition and processing, antibody-antigen interactions, cell-cell interactions, cell death, etc.
C19612	Legislative_Liaison	Miscellaneous_Occupations	Legislative Liaison	A go-between in the legislature
C19613	Mammalian_Genetics	Genetics	Mammalian Genetics	The branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance in animals of the class Mammalia.
C19614	Manpower_and_Training	Medical_Economics	Manpower and Training
C19615	Neuropharmacology_and_Toxicology	Pharmacology	Neuropharmacology and Toxicology|Neuropharmacology / Toxicology	"The branch of pharmacology dealing especially with the action of drugs upon various parts of the nervous system. "
C19616	James_A_Shannon_Directors_Award	Research_Project_Grants	James A. Shannon Director's Award|R55 Mechanism|R55 Program|Shannon Awards
C19617	Yeast_Model_System	Fungi_Model	Yeast Model System|Yeast Model	Pathways and other molecular and cellular processes which can be manipulated in yeast, the results of which can be extrapolated to human systems.
C19618	Signal_Transducer_and_Activator_of_Transcription	Signaling_Protein|Transcription_Factor	Signal Transducer and Activator of Transcription|STAT|STAT Protein	Cytoplasmic proteins that are activated by phosphorylation in response to a large number of cytokines, growth factors, and hormones.  They dimerize and translocate to the nucleus upon activation, where they bind to regulatory cis-elements of specific target genes.
C19619	RNA_Metabolism_Processing_and_Transport	Retired_Concepts	RNA Metabolism: Processing and Transport	RNA Metabolism Processing and Transport involves biochemical and biophysical modifications of nascent RNA transcripts into developed functional ribonucleic acid species and transfer, typically complexed with specific proteins, to target cellular locations to sustain certain cell functions.
C19620	GFP-NIC96	Fusion_Protein	GFP-NIC96|pSW950	NIC96 is a nuclear pore protein identified in yeast.  GFP stands for green fluorescent protein. GFP-NIC96 was used for cell localization studies in vivo.
C19621	Metastasize	Conceptual_Entities	Metastasize|metastasize	(meh-TAS-ta-size) To spread from one part of the body to another. When cancer cells metastasize and form secondary tumors, the cells in the metastatic tumor are like those in the original (primary) tumor.
C19622	Clinical_Oncology	Clinical_Medicine|Oncology	Clinical Oncology	The medical specialty that focuses on clinical aspects of the diagnosis, treatment, and prevention of cancers. (NCI 2005)
C19623	Biomarkers_and_Prevention_Research_Branch	Component_of_the_Division_of_Cancer_Prevention	Biomarkers and Prevention Research Branch|Biomarkers and Prevention	The Branch plans and conducts intramural research aimed at identifying new tools for the early detection of cancers and developing cancer intervention agents. (from Division of Cancer Prevention and Control 1994 Annual Report)
C19624	Scientific_Evaluation	Grant_Review_Process	Scientific Evaluation
C19625	Cytoskeleton_Tumor_Biology	Tumor_Cell_Biology	Cytoskeleton/Tumor Biology
C19626	Neural_Growth_Development_Degeneration	Developmental_Neurobiology	Neural Growth/Development/Degeneration
C19627	DNA_Replication_and_Repair	Retired_Concepts	DNA Replication and Repair
C19628	Education_and_Outreach	Patient_or_Public_Education	Education and Outreach
C19629	Radiation-Induced_Gene_Expression	Gene_Expression	Radiation-Induced Gene Expression|Gene Expression, Radiation	Radiation-Induced Gene Expression involves activation or enhanced activity in the expression of a gene as a result of radiation.
C19631	Immune_Targeting	Molecular_Biology_Techniques	Immune Targeting	The process of experimentally manipulating the immune response in order to redirect its specificity and intensity by developing novel molecular, chemical, and cellular procedures to alter the outcome of immune reactions.(NCI2005)
C19632	Leukocyte_Cell_Biology	Cellular_Immunology	Leukocyte Cell Biology
C19633	Lymphocyte_Function	Lymphocyte_Biology	Lymphocyte Function
C19634	NCI_Strategic_Planning	Strategic_Planning	NCI Strategic Planning
C19635	BRCA1_Mutation	Gene_Abnormality	BRCA1 Mutation|Mutation of the BRCA1 Gene	A mutation that is typically a heritable, permanent change in the nucleotide sequence of the BRCA1 gene. Single nucleotide substitutions and small deletions or insertions (1-20 bases) account for the majority of mutations in the BRCA1 gene. Approximately 75% of these alterations result in a truncated form of the breast cancer type 1 susceptibility protein. Mutations in the BRCA1 gene predispose individuals to breast and ovarian cancers.
C19636	BRCA2_Mutation	Gene_Abnormality	BRCA2 Mutation|Mutation of the BRCA2 Gene	A mutation that is typically a heritable, permanent change in the nucleotide sequence of the BRCA2 gene. Single nucleotide substitutions and small deletions or insertions (1-20 bases) account for the majority of mutations in the BRCA2 gene. Most of these alterations result in a truncated form of the breast cancer type 2 susceptibility protein. Mutations in the BRCA2 gene predispose males to breast cancer.
C19637	Five_Prime_Nucleotidase	Esterase	5' Nucleotidase|5'-N'Tase|5'-NT|5-Nucleotidase	A class of enzymes present in various organs and in many cells that catalyze the hydrolysis of a 5'-ribonucleotide to a ribonucleoside and orthophosphate in the presence of water. Serum 5'-N'Tase is measured as an indicator of liver damage resulting primarily from interference with the secretion of bile. Serum 5'-N'Tase is not as sensitive as some other enzymes (for example, ALP, AST, and ALT) to liver damage, but it is a more liver-specific enzyme. The level of this enzyme parallels alkaline phosphatase (ALP). It is used mostly to differentiate elevations in the above enzymes due to liver damage from damage to skeletal muscle.
C19638	Classical_Mechanics	Physics	Classical Mechanics	Its fundamental principle is that any physical system can be decomposed into a collection of simple independent local elements each of which interacts only with its immediate neighbors.  In classical mechanics a complete description of any physical system is supposed to be specified by giving the values of the various fields (e.g., the electric field, the magnetic field, etc.) at each of the relevant spacetime points."
C19639	Clone-Based_Physical_Mapping	Gene_Mapping	Clone-Based Physical Mapping	A procedure for determining the specific physical locations of genes and markers on each chromosome, using an ordered library of cloned DNA fragments according to their position in the genome, typically with some physically measurable metric, eg, base pairs, kilobases, and megabases.
C19640	Clusters_of_Orthologous_Groups_of_Genes	Conceptual_Entities	Clusters of Orthologous Groups of Genes|COG	Each COG consists of individual orthologous proteins or orthologous sets of paralogs from at least three lineages. Orthologs typically have the same function, allowing transfer of functional information from one member to an entire COG.  (from Science 1997;278:631-7)
C19641	Dideoxy_Chain_Termination_DNA_Sequencing	Nucleic_Acid_Sequencing	Dideoxy Chain Termination DNA Sequencing|Sanger Sequencing	DNA sequencing in which chain termination is caused by incorporation of a dideoxynucleotide into a growing DNA strand.
C19642	Founder_Generation	Population_Group	Founder Generation
C19643	Gene_Combinations	Miscellaneous_Molecular_Biology_Terms	Gene Combinations
C19644	Genotypic_Risk_Ratio	Risk_Estimate	Genotypic Risk Ratio
C19645	Large-Scale_Sequencing	Nucleic_Acid_Sequencing	Large-Scale Sequencing	Large scale sequencing is the process of determining of the precise sequence of nucleotides in the entire genome of an organism. (NCI2005)
C19646	Shotgun_Sequencing	Large-Scale_Sequencing	Shotgun Sequencing	Unordered sequencing.  Unmapped clones spanning a region of interest are sequenced and then assembled into a continuous sequence.
C19647	Linkage_Disequilibrium_Mapping	Gene_Mapping	Linkage Disequilibrium Mapping	Linkage disequilibrium (LD) mapping is a procedure for determining the non-random association of alleles at two or more loci on a chromosome. It is based on the premise that regions adjacent to a gene of interest are transmitted through the generations along with that gene and can be identified by the specific pattern of markers (haplotypes) that they contain, so that detection of haplotypes that are shared more frequently among groups of individuals recruited for a disease or trait can be used to locate specific genes. Linkage-disequilibrium (LD) mapping is useful in identifying genes involved in complex diseases.
C19648	Phylogenetic_Patterns	Pattern	Phylogenetic Pattern|Phylogenetic Patterns
C19649	Protein_Dynamics	Protein_Biochemistry	Protein Dynamics
C19650	Quantum_Mechanics	Physics	Quantum Mechanics
C19651	Shotgun_Sequence_Assembly	Molecular_Biology_Techniques	Shotgun Sequence Assembly	The assembly of a complete stretch of DNA sequence from a set of sub-sequences whose order in the longer stretch is unknown.  Requires the use of computerized sequence analyses to determine the correct order of fragments in order to assemble to entire stretch of DNA sequence.
C19652	Statistical_Mechanics	Physics	Statistical Mechanics	Statistical mechanics explains the macroscopic thermodynamic properties in terms of microscopic properties of chemical systems.
C19653	Whole-Genome_Shotgun_Sequencing	Shotgun_Sequencing	Whole-Genome Shotgun Sequencing	A DNA sequencing method, which involves random sequencing of tiny cloned pieces of the genome, with no foreknowledge of where on a chromosome the piece originally came from. The sequences obtained have a considerable overlap and by using appropriate computer software it is possible to compare sequences and align them to build larger units of genetic information. This sequencing strategy can be automated and leads to rapid sequencing information.(NCI2005)
C19654	YAC-Based_STS-Content_Mapping	Clone-Based_Physical_Mapping	YAC-Based STS-Content Mapping	YAC based content mapping is a clone-based physical genome mapping strategy. Content mapping is done by ordering sequence tagged sites (STS), regions of the genome which can be uniquely identified, and YAC (Yeast Artificial Chromosome) clone ends along the chromosome, based on the STS content of each clone, for constructing a composite map that represents the linear order and position of mapping landmarks along the genome. (NCI2005)
C19655	YAC_Cloning	Cloning	YAC Cloning|YAC Cloning System	Yeast artificial chromosomes or YAC is a vector system for cloning genomic DNA for genomic map construction and can carry from 100 to >2000 kb of foreign DNA.(NCI2005)
C19656	Signal_Induction	Cell_Signaling_Process	Signal Induction	Signal induction is the intercellular or intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (e.g., hormone, neurotransmitter, etc.) is transferred to a receptor molecule through a physical binding interaction that alters the conformational and functional state of the receptor molecule and promotes an alteration in cell function.
C19657	Recombinant_Haplotype	Genotype	Recombinant Haplotype	A haplotype is the order of gene alleles present on a particular chromosome.  Thus, a recombinant haplotype exists when a particular haplotype does not match those of either parent.
C19658	Radioactive_Sequencing	Nucleic_Acid_Sequencing	Radioactive Sequencing	Classical technique for sequencing nucleic acids in which visualization of the bases in the sequence relies on the use of radioactive materials, either radiolabeled nucleic acid strands in the chemical degradation method (Maxam-Gilbert), or radiolabeled nucleotides in the dideoxy-termination method (Sanger).
C19659	System_for_Public_Use	Computer_System	System for Public Use	Computer systems designs for direct use of the public.
C19660	School_Drop-Outs	At-Risk_Population	School Drop-Outs	Individuals who have withdrawn from school.
C19661	Breast_Cancer_Surveillance_Consortium	NCI_Consortium_or_Network	Breast Cancer Surveillance Consortium	Comprised of nine academic and public institutions and private organizations. The consortium's three main objectives are: 1) To better understand breast cancer screening practices in the United States by assessing the accuracy, cost, and quality of screening programs and the relation of these practices to changes in breast cancer mortality and other outcomes, such as survival; 2) To foster collaborative research among Consortium participants that examines issues such as regional and health care system differences in the provision of screening and follow-up evaluations; and 3) To provide a foundation for conducting clinical and basic science research, especially basic research on biological mechanisms, that can improve our understanding of the natural history of breast cancer.
C19662	Lifetime_Risk	Risk_Estimate	Lifetime Risk	An estimate of cumulative risk calculated over a lifetime.
C19663	Cell-Cell_Adhesion	Cell_Adhesion	Cell-Cell Adhesion	Mechanisms whereby cells attach together to form tissues.
C19664	Angiogenic_Switch	Neovascularization	Angiogenic Switch	Loss of the balance between stimulation and inhibition of new blood vessel growth.  A required early step in cancer growth and metastasis.
C19665	Breast_Cancer_Risk_Assessment_Tool	Computer_Program	Gail Risk Model|Breast Cancer Gail Model|Breast Cancer Gail Model Risk Assessment Tool|Breast Cancer Risk Assessment Tool|Gail model	A computer program developed through the National Surgical Adjuvant Breast and Bowel project.  Estimates risk of breast cancer based upon current age, age at menarche, age at first live birth, number of first-degree relatives who have had breast cancer, number of breast biopsies, and number of biopsies with atypical hyperplasia.  Results are presented as risk of breast cancer, as a percentage, within the next five years or over a lifetime.
C19666	Age_at_Menarche	Personal_Attribute	Age at Menarche	Age of first menstruation.  A risk factor for breast cancer
C19667	Age_at_First_Live_Birth	Personal_Attribute	Age at First Live Birth|Age at First Full-Term Pregnancy	A risk factor for breast cancer
C19668	Tobacco_Research_Implementation_Group	Professional_Organization_or_Group	Tobacco Research Implementation Group|TRIG	Created to establish NCI's tobacco-related cancer research priorities for the next five to seven years.  The first initiative of the group creates a collaborative Transdisciplinary Tobacco Research Centers program.  The second program funds state and community tobacco control intervention research.
C19669	Glioma_Marker_Network	NCI_Consortium_or_Network	Glioma Marker Network	A group of of six collaborating laboratories at medical centers located throughout the U.S. working to identify new molecular alterations that may be useful for brain tumor diagnosis.
C19670	Vasculostatin	Angiogenesis_Inhibitory_Protein	Vasculostatin|NID	Vasculostatin is the 20 kDa C-terminal domain of the vascular basement protein, Nidogen-1.  It has anti-angiogenic properties and is being investigated for clinical applications. (from http://research.bidmc.harvard.edu/OCR/tvotech.asp?Submit=Title&ID=578 and NCI)
C19671	Histone_Deacetylase-1	Histone_Deacetylase	Histone Deacetylase 1|HDAC1	Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. This protein belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. (LocusLink)
C19672	Histone_Deacetylase-3	Histone_Deacetylase	Histone Deacetylase 3|HDAC3	Histone deacetylase 3 is one of three identified histone deacetylases with similarity to the yeast global transcriptional regulator Rpd3p.  Two isoforms are produced by alternative splicing and it appears to be expressed ubiquitously.  HDAC3 can be found in complexes that include HDAC4 and HDAC5, deacetylases with similarity to yeast Hda1 deacetylase.  HDAC3 may regulate transcription through binding the zinc-finger transcription factor YY1, increasing its repression activity.  RELA is a nonhistone substrate of HDAC3.  IKBA-dependent nuclear export of deacetylated RELA replenishes the cytoplasmic pool of NFKB/IKBA complexes for NFKB responses.  (from OMIM 605166 and NCI)
C19673	Histone_Deacetylase-4	Histone_Deacetylase	Histone Deacetylase 4|HDAC-A|HDAC4|Histone Deacetylase A	Histone deacetylase 4 is one of three identified histone deacetylases with similarity to the yeast Hda1 histone deacetylase.  It is expressed differentially in brain, heart, and skeletal muscle and is found in complexes with HDAC3 and HDAC5.  HDAC4 possesses deacetylation activity with all four core histones.  HDAC4 interacts with multiple proteins.  HDAC4 does not bind DNA directly, but rather through MEF2C and MEF2D.  Binding of HDAC4 to MEF2C represses MEF2C transcription activity.  (from OMIM 605314 and NCI)
C19674	Scaffold_Attachment_Factor-B	Nuclear_Matrix_Protein	Scaffold Attachment Factor B|Chromatin-Associated DNA-Binding Protein B|HET|HET Scaffold Attachment Factor B|HET/SAF-B Protein|HSP27 ERE and TATA-Binding Protein|HnRNP A1 Associated Protein|Hsp27-ERE-TATA-Binding Protein|SAFB	Encoded by human SAFB Gene, HET Scaffold Attachment Factor B is a highly charged monomeric 915-amino acid scaffold attachment factor with high S/MAR (Scaffold/Matrix-Associating Region) DNA-binding specificity; scaffold attachment factors A, B, C, and D interact with S/MAR DNA. The protein contains potential phosphorylation, glycosylation, and myristylation sites. Eukaryotic interphase chromatin is organized in thousands of loop domains fixed at their base through genomic S/MAR sequences to a nuclear matrix network of protein and RNA important for chromatin compaction, gene expression, and replication. SAFB is a HSP27 promoter-binding protein that decreases HSP27 transcription as an estrogen receptor corepressor. SAFB also interacts with RNA polymerase II and serine-/arginine-rich RNA processing factors and may help to assemble a 'transcriptosome complex' near active genes. (from OMIM and NCI)
C19675	XRCC1_Gene	DNA_Repair_Gene	XRCC1 Gene|RCC|X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 1 Gene|XRCC1	The XRCC1 gene at 19q13.2 encodes XRCC1, which functions in the repair of single-strand DNA breaks and sister chromatid exchange. With no catalytic activity, XRCC1 is required to interact with polynucleotide kinase (PNK) and poly(ADP-ribose) polymerase, linking DNA polymerase-beta and DNA ligase III (LIG3) with single-strand break repair and short-patch base excision repair, respectively, after treatment with ionizing radiation and alkylating agents. In the initial step of processing damaged DNA ends, XRCC1 stimulates the DNA kinase and DNA phosphatase activities of PNK at damaged DNA termini, thus accelerating the overall repair reaction in mammalian single-strand break repair pathway. XRCC1 is also required for full activity of LIG3 in rejoining of broken DNA strands. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
C19676	DNA_Repair_Gene	Gene	DNA Repair Gene	DNA Repair Genes encode DNA Repair Proteins, involved in enzymatic restoration of DNA structure after chemical, radiation, or spontaneous damage. (NCI)
C19677	APEX1_Gene	DNA_Repair_Gene	APEX1 Gene|AP Endonuclease Class I Gene|AP Lyase Gene|APE Gene|APEN Gene|APEX Gene|APEX Nuclease (Multifunctional DNA Repair Enzyme) 1 Gene|APEX Nuclease (Multifunctional DNA Repair Enzyme) Gene|APEX1|APX Gene|Apurinic Endonuclease Gene|Apurinic/Apyrimidinic Exonuclease Gene|DNA-(Apurinic or Apyrimidinic Site) Lyase Gene|Deoxyribonuclease (Apurinic or Apyrimidinic) Gene|HAP1 Gene|Human Apurinic Endonuclease 1 Gene|Multifunctional DNA Repair Enzyme Gene|REF-1 Gene|REF1 Gene|Redox Factor 1 Gene	Human APE1 Gene (AP/EXOA family) at 14q12 encodes APEX Nuclease, a ubiquitous monomeric apurinic/apyrimidinic DNA repair endonuclease (AP/EXOA family) having 3-prime-, 5-prime-exonuclease, DNA 3-prime repair diesterase, and DNA 3-prime-phosphatase activities. The constitutive gene contains five exons spanning 2.64 kb; the first exon is untranslated.  The 0.5 kb upstream DNA contains only a possible CCAAT box and no other regulatory sites or a TATA box.  A potent activator of p53 protein, APE1 may protect against cell lethality and suppress mutations produced by spontaneous hydrolysis, by chemicals and radiation, or by DNA glycosylases that remove abnormal bases from DNA; abasic sites that can block DNA replication and cause mutations must be corrected to restore genetic integrity. A repressor of the PTH gene, APE binds to promoter negative Ca(2+)-response elements, which are also present in the APE1 gene. (NCI)
C19678	Histone_Deacetylase-5	Histone_Deacetylase	Histone Deacetylase 5|HDAC5	Histone deacetylase 5 is one of three identified histone deacetylases with similarity to the yeast Hda1 histone deacetylase.  It is expressed differentially, is found in complexes with HDAC4 and HDAC3, and possesses deacetylation activity with all four core histones.  MEF2A transcription factors interact with HDAC4 and HDAC5, resulting in repression of MEF2-dependent genes.  Muscle differentiation requires release of MEF2 from repression by HDACs.  HDAC5 shuttles from nucleus to cytoplasm when myoblasts are triggered to differentiate.  CAMK1 signaling prevents formation of MEF2/HDAC complexes and induces nuclear export of HDAC4 and HDAC5 by phosphorylation.
C19679	Histone_Deacetylase-6	Histone_Deacetylase	Histone Deacetylase 6|HDAC6	HDAC6 functions as a tubulin deacetylase. HDAC6 is localized exclusively in the cytoplasm, where it associates with microtubules and localizes with the microtubule motor complex. In vivo the overexpression of HDAC6 led to a global deacetylation of alpha-tubulin, whereas a decrease in HDAC6 increased alpha-tubulin acetylation. In vitro, purified HDAC6 potently deacetylated alpha-tubulin in assembled microtubules. Furthermore, overexpression of HDAC6 promoted chemotactic cell movement, supporting the idea that HDAC6-mediated deacetylation regulates microtubule-dependent cell motility. Hubbert et al. (2002) concluded that HDAC6 is the tubulin deacetylase, and provided evidence that reversible acetylation regulates important biologic processes beyond histone metabolism and gene transcription. (from OMIM)
C19680	Biostatistical_Methods	Statistical_Methods	Biostatistical Methods	Techniques used to statistically analyze biological data.
C19681	Dietary_Questionnaires	Questionnaire	Dietary Questionnaires
C19682	Mutation_Fixation	Population_Process	Mutation Fixation	In avoiding recognition and removal by the mismatch repair system, a Mutation Fixation involves stabilization of a DNA sequence alteration in both strands so that the sequence change is propagated to progeny cells.
C19683	Personal_Behavior	Behavior	Personal Behavior|Personal Conduct	The observable response of a person.
C19684	Training_of_Investigators	Training	Training of Investigators
C19685	Biology_of_Aging	Developmental_Biology	Biology of Aging
C19686	Clonal_Evolution	Cancer_Cell_Growth	Clonal Evolution	The changes that occur in the population of tumor cells during the course of the disease
C19687	Communication_Tools	Information_and_Communication_Theory	Communication Tools
C19688	Exogenous_Factors	Epidemiological_Factors	Exogenous Factors|Environmental Factors	Environmental factors considered as variables in disease incident, transmission, and control.
C19689	Organ_Model	in_vitro_Model	Organ Model	Use of in vitro tissues or organ explants as surrogates for whole organism testing.
C19690	Predictive_Cancer_Model	Cancer_Model	Predictive Cancer Model
C19691	Cancer_Model	Model_System	Cancer Model	Any model that can be used to study issues important in cancer such as cancer development or prediction.
C19692	Tissue_Model	in_vitro_Model	Tissue Model
C19693	Endogenous_Factors	Epidemiological_Factors	Endogenous Factors	The consideration of naturally occurring body factors as a variable in disease incident, transmission, and control.
C19694	Risk_Reduction	Personal_Behavior	Risk Reduction
C19695	Audiovisual_Material	Media	Audiovisual Material|Audiovisual Materials	Materials using sight or sound to present information.
C19696	Sites_of_Care_Delivery	Geographic_Area	Sites of Care Delivery	Any place at which medical services are rendered.  It includes traditional locations such as hospitals, clinics, and nursing homes as well as less traditional sites such as schools, supermarkets, and worksites.
C19697	Tissue_Sample	Specimen	Tissue Sample
C19698	Cancer_Advocacy	Advocacy	Cancer Advocacy
C19699	Cancer_Gene_Mutation	Gene_Mutation	Cancer Gene Mutation	A Cancer Gene Mutation is a permanent and heritable change in the nucleotide sequence of a gene that changes or abolishes function and predisposes or promotes neoplastic cellular transformation.
C19700	Cancer_Patient	Patient	Cancer Patient	A person who receives medical care for the purpose of treating, diagnosing or preventing cancer.
C19701	Cancer_Death_Rates	Mortality	Cancer Death Rates	mortality due to cancer.
C19702	Cigar_Smoking	Tobacco_Smoking	Cigar Smoking
C19703	Clinical_Oncology_Supplement_K12	Physician_Scientist_Award_Program	Clinical Oncology Supplement (K12)|Clinical Oncology Research Career Development Program|Clinical Oncology Research Career Development Program (K12)|Institutional Clinical Oncology Research Career Development Program (K12)|K12 Award
C19704	Clinical_Research_Curriculum_Award	Research_Career_Programs_K-Series	Clinical Research Curriculum Award (CRCA)|K30 Mechanism|K30 Program
C19705	Prostaglandin-Endoperoxide_Synthase-1	Cyclooxygenase	Prostaglandin-Endoperoxide Synthase 1|COX|COX-1|COX1|COX3|Cyclo-Oxygenase-1|Cyclooxygenase|Cyclooxygenase 3|Cyclooxygenase-1|Fatty Acid Cyclooxygenase|PGH Synthase|PGH Synthase 1|PGHS-1|PHS1|PTGS|PTGS1|Prostaglandin G/H Synthase 1|Prostaglandin G/H Synthase and Cyclooxygenase|Prostaglandin H2 Synthase|Prostaglandin H2 Synthase 1|Prostaglandin-Endoperoxide Synthase	COX-1 is known to be present in most tissues as the housekeeper enzyme, maintains normal gastric mucosa and influences kidney function, while COX-2 is inducible by inflammation. They share 60% homology. The expression of Cox-1 is induced by cytokines and mitogens, hence it is likely to play a role in inflammatory diseases such as rheumatoid arthritis. It contains one EGF-like domain.  Both isoforms have the same affinity to convert arachidonic acid to prostaglandin. COX-1. Both forms of COX proteins are membrane associated heme proteins containing cyclooxygenase and peroxidase activities. These enzymes are targets of NSAID (Non steroidal anti-inflammatory drugs) such as aspirin.
C19706	Dietary_Practices	Personal_Behavior	Dietary Practices	Dietary Practices refers to a person's choices in food consumption.
C19707	AIDS_Malignancy_Consortium	NCI_Consortium_or_Network	AIDS Malignancy Consortium|AMC	Established in 1995 to carry out Phase I and II studies of innovative therapies for AIDS malignancies.
C19708	AIDS_Oncology_Research_Handbook	Book	AIDS Oncology Research Handbook
C19709	American_College_of_Surgeons	Professional_Organization_or_Group	American College of Surgeons|ACS	A scientific and educational association of surgeons with the main goal to improve the quality of care for the surgical patient by setting high standards for surgical education and practice.
C19710	Environmentally_Produced_Gene_Alteration	Gene_Mutation	Gene Alteration, Environmentally Produced|Environmentally Produced Alteration of Gene|Environmentally Produced Gene Alteration	An Environmentally Produced Gene Alteration involves a change in the chemical composition of the DNA within a gene domain as a result of the influence of an external factor derived from the environment.
C19711	Professional_Organization_or_Group	Population_Group	Professional Organization or Group|ORG|ORGS|Organization|Organizations	A formal group of people with one or more shared goals.
C19712	American_College_of_Surgeons_Oncology_Group	Clinical_Trials_Cooperative_Group	American College of Surgeons Oncology Group|ACOSOG	A cooperative group sponsored by the NCI whose primary goal is to evaluate surgical therapies in the management of patients with malignant solid tumors. The ACOSOG (Durham, NC) includes general and specialty surgeons, representatives of related oncologic disciplines and allied health professionals in academic medical centers and community practices throughout the US and foreign countries. The group is composed of the Administrative Coordinating Center and the Statistics and Data Coordinating. Both groups are based at the Duke Clinical Research Institute.
C19713	Oncology_Group	Professional_Organization_or_Group	Oncology Group
C19714	Bypass_Budget	Document_Type	Bypass Budget	The Bypass Budget, which is specified in the National Cancer Act, describes the NCI's priorities and planning and guides NCI efforts in discharging its responsibilities as mandated.
C19715	Cancer_Center_Support_Grant	NCI_Program_T_P_or_N	Cancer Center Support Grant|CCSG|Core Grant|P30 Grant	The Cancer Center Support Grant (P30) is an NCI grant to help fund designated centers' infrastructure of administration and core facilities.
C19716	Cancer_Cluster	Hot_Spot	Cancer Cluster	A geographic area displaying a higher-than-expected rate of cancer incidence.
C19717	Cancer_Education_Grant_Program_CEGP	Education_Projects	Cancer Education Grant Program|Cancer Education Grant|Cancer Education Grant (R25)|Cancer Education Grant Program (CEGP)|Cancer Education Program (R25)|R25 Grant|R25E Award
C19718	Cancer_Genetics_and_Epidemiology_Fellowship_Program	Fellowship_Programs	Cancer Genetics and Epidemiology Fellowship Program
C19719	Cancer_Genetics_Education_Program	Patient_or_Public_Education	Cancer Genetics Education Program
C19720	Cancer_Research_Network	Professional_Organization_or_Group	Cancer Research Network	Ten major, non-profit managed care organizations that are members of the HMO Research Network will participate in the project, known as the Cancer Research Network. A key goal of the Cancer Research Network project is identifying the patient, treatment and delivery system factors that may make a difference in health outcomes for cancer. By combining the data capacities of these large integrated health systems, researchers will be able to study health care patterns among millions of patients who mirror the diversity of the nation in terms of age, gender, income, education, cultural background and location.
C19721	CancerFax	Educational_Materials	CancerFax	Includes NCI information about cancer treatment, screening, prevention, and supportive care.  Can be accessed by telephone with information returned by FAX.
C19722	CancerLit	Educational_Materials	CancerLit	CANCERLIT is an NCI bibliographic database of more than 1.4 million records of cancer literature published in the past 30 years. It is updated monthly to provide a comprehensive up-to-date resource of published cancer research results.
C19723	Cancer_Grant_Supplements_P30	NCI_Program_T_P_or_N	Cancer Grant Supplements (P30)|Cancer Grant Supplements|P30 Award|P30 Grant
C19724	Childrens_Cancer_Group	Retired_Concepts	Children's Cancer Group
C19725	Clinical_Cancer_Center	NCI-Designated_Cancer_Center	Clinical Cancer Center
C19726	Clinical_Intramural_Research_Award	Intramural_Research_Award	Clinical Intramural Research Award
C19727	Colorectal_Cancer_Surveillance_Consortium	NCI_Consortium_or_Network	Colorectal Cancer Surveillance Consortium|CCSC
C19728	Colorectal_Cancer_Surveillance_Health_Information_System	Health_Information_System	Colorectal Cancer Surveillance Health Information System
C19729	Comprehensive_Cancer_Center	NCI-Designated_Cancer_Center	Comprehensive Cancer Center	NCI-designated cancer center established to be national leaders in cancer treatment, research, and education.
C19730	Comprehensive_Minority_Biomedical_Program	Component_of_the_Office_of_the_Director	Comprehensive Minority Biomedical Program|CMBP|Comprehensive Minority Biomedical Branch (CMBB)	The Comprehensive Minority Biomedical Program (CMBP) represents an effort by the NCI to broaden participation in cancer-related research and training activities by minorities, individuals with disabilities, and individuals seeking to reenter an active research career after taking time off to attend to family responsibilities. The CMBP also seeks to enhance the effectiveness of programs in cancer treatment and cancer control in reaching the minority community and other historically underserved segments of the general population.
C19731	FDA_Modernization_Act_of_1997	Business_Rules	FDA Modernization Act of 1997|FDAMA
C19732	Continuing_Umbrella_of_Research_Experience_for_Underserved_Minorities_Program	Award	Continuing Umbrella of Research Experience for Underserved Minorities (CURE) Program|CURE|Continuing Umbrella of Research Experience for Underrepresented Minorities Program|Continuing Umbrella of Research Experiences	The Continuing Umbrella of Research Experience for Underrepresented Minorities Program (CURE) is a new strategy being implemented by the National Cancer Institute to expose minorities to cancer research at the high school and undergraduate levels. The program is being initiated nationwide.
C19733	Cooking_Practices	Personal_Behavior	Cooking Practices	Cooking Practices refers to methods of preparing foods and their role in health and disease.
C19734	Grants_Applications	Document_Type	Grants, Applications|Grant Proposals
C19735	Grant_Review	Grant_Referral_and_Review	Grant Review
C19736	Heightened_Cancer_Risk	Cancer_Risk	Heightened Cancer Risk
C19737	Cooperative_Agreements_U-Series	Funding_Mechanisms	Cooperative Agreements, U-Series|Cooperative Agreements	U01:Research Project (Cooperative Agreements).  U10:Cooperative Clinical Research (Cooperative Agreements).  U13:Conference (Cooperative Agreement).  U26:Organ Systems Coordinating Center (Cooperative Agreements). (Grant Guidelines and Descriptions, NCI)
C19738	Cooperative_Research_and_Development_Agreement	Document_Type	Cooperative Research and Development Agreement|CRADA	A mechanism for collaboration between government and outside scientists that legally defines intellectual property rights and financial and other responsibilities.
C19739	Epidemiology_and_Biostatistics_Fellowship	Fellowship_Programs	Epidemiology and Biostatistics Fellowship
C19740	Established_Investigator_in_Cancer_Prevention_Control_and_Population_Sciences_Award_K05	Senior_Scientist_Award	Established Investigator in Cancer Prevention, Control, and Population Sciences Award (K05)
C19741	European_Organization_for_Research_and_Treatment_of_Cancer	Clinical_Trials_Cooperative_Group	European Organization for Research and Treatment of Cancer|EORTC	A group with aims to conduct, develop, coordinate, and stimulate laboratory and clinical research in Europe to improve the management of cancer and related problems by increasing survival but also patients' quality of life. There are more than 60 institutions and departments that have been recognized by EORTC as affiliated. These groups conduct, on a voluntary basis, laboratory research and/or clinical trials on all types of cancers using a multidisciplinary approach. EORTC maintains close working relationship with NCI and the British Cancer Research United Kingdom in London.
C19742	Gamma_Particles	Retired_Concepts	Gamma Particle
C19743	Genetic_Status	Personal_Attribute	Genetic Status	the state of a person's genome at a given time.
C19744	Hot_Spot	Geographic_Area	Hot Spot|Hot Spots (Area of Increased Mortality)	A hotspot is a center of high activity within a larger area of low activity. The term is applied to different things in different areas of study. (from Wikipedia)
C19745	Hormonal_Risk_Factor	Risk_Factor	Hormonal Risk Factor	Increase in the chance of developing a disease, due to hormonal factors.
C19746	Human_Cancer_Pathology	Human_Pathology	Human Cancer Pathology
C19747	Imaging_Device	Diagnostic_Therapeutic_and_Research_Equipment	Imaging Device|Imaging Tool	A device for producing a representation or picture, usually of a part of the body, to aid in diagnosis and evaluation
C19748	Laboratory_of_Population_Genetics	Component_of_the_Division_of_Cancer_Epidemiology_and_Genetics	Laboratory of Population Genetics
C19749	Interactive_Kiosk	Interactive_Communication	Interactive Kiosk
C19750	Mouse_Models_of_Human_Cancer_Consortium	NCI_Consortium_or_Network	Mouse Models of Human Cancer Consortium|MMHCC	A program to develop and refine experimental models that reflect the etiology and progression of human cancer.
C19751	National_Action_Plan_on_Breast_Cancer	NCI_Advisory_Boards_and_Groups	National Action Plan on Breast Cancer|NAPBC	The National Action Plan on Breast Cancer (NAPBC) is a public-private partnership created to eliminate the epidemic of breast cancer.
C19752	National_Health_Interview_Survey	Interview	National Health Interview Survey	Since its inception in 1957, the NHIS has been a continuing nationwide sample survey in which data are collected through personal interviews with household members by U.S. Bureau of the Census interviewers. Data are used to provide national estimates on the incidence of acute conditions, the prevalence of chronic conditions and impairments, the extent of disability, the utilization of health care services (physician visits and hospital episodes), and other health-related topics. All conditions are coded according to the International Classification of Diseases. The survey is periodically redesigned to emphasize data collection on current health issues. (Alcohol Epidemiologic Data Directory, June 2000)
C19753	National_Institute_of_Allergy_and_Infectious_Disease	Component_of_the_National_Institutes_of_Health	National Institute of Allergy and Infectious Disease|NIAID
C19754	National_Institute_of_Child_Health_and_Human_Development	Component_of_the_National_Institutes_of_Health	National Institute of Child Health and Human Development|NICHD
C19755	National_Institute_of_Dental_Research	Component_of_the_National_Institutes_of_Health	National Institute of Dental Research|NIDR
C19756	National_Institute_of_Digestive_Diseases_and_Kidney_Disorders	Component_of_the_National_Institutes_of_Health	National Institute of Digestive Diseases and Kidney Disorders|NIDDK
C19757	National_Institute_of_Drug_Abuse	Component_of_the_National_Institutes_of_Health	National Institute of Drug Abuse|NIDA
C19758	National_Institute_of_Nursing_Research	Component_of_the_National_Institutes_of_Health	National Institute of Nursing Research
C19759	Mentored_Clinical_Oncology_Award	Mentored_Patient-Oriented_Research_Career_Development_Award	Mentored Clinical Oncology Award (K23)|K23 Award
C19760	National_Wilms_Tumor_Study_Group	Professional_Organization_or_Group	National Wilms' Tumor Study Group|NWTS	A group established in 1969 with goals: to improve the survival of children with Wilms tumor and other renal tumors, to study the long-term outcome of children treated successfully by identifying adverse effects of treatment, to study the epidemiology and biology of Wilms tumor and to make information regarding successful treatment strategies for Wilms tumor available to physicians around the world. In 2001 NWTSG was merged into the Children's Oncology Group. Patient entry into NWTSG clinical trial protocols was completed in 2002.
C19761	Mentored_Clinical_Scientist_Award	Mentored_Patient-Oriented_Research_Career_Development_Award	Mentored Clinical Scientist Award (K23)|K23 Award
C19762	Network_for_Research_on_Cancer_in_Children	Cancer_Research_Network	Network for Research on Cancer in Children
C19763	Mentored_Patient-Oriented_Research_Career_Development_Award	Research_Career_Programs_K-Series	Mentored Patient-Oriented Research Career Development Award|K23 Award|K23 Mechanism|K23 Program|Mentored Patient-Oriented Research Career Development Award (K23)
C19764	NIH_Center_for_Scientific_Review	Component_of_the_National_Institutes_of_Health	NIH Center for Scientific Review|CSR|Division of Research Grants	The Center for Scientific Review (CSR) provides staff support to the Office of the Director, NIH, in the formulation of grant application review policies and procedures. In addition, CSR provides central receipt of all PHS applications for research and review.
C19765	NIH_Office_of_AIDS_Research	Component_of_the_National_Institutes_of_Health	NIH Office of AIDS Research
C19766	NIH_Vaccine_Research_Center	Component_of_the_National_Institutes_of_Health	NIH Vaccine Research Center
C19767	Number_of_First_Degree_Relatives_Affected	Personal_Attribute	Number of First Degree Relatives (Affected)|First Degree Relatives
C19768	Mid-Career_Clinical_Scientist_Award	Midcareer_Investigator_Award_in_Patient-Oriented_Research	Mid-Career Clinical Scientist Award (K24)|K24 Award
C19769	Midcareer_Investigator_Award_in_Patient-Oriented_Research	Research_Career_Programs_K-Series	Midcareer Investigator Award in Patient-Oriented Research|K24 Mechanism|K24 Program|Midcareer Investigator Award in Patient-Oriented Research (K24)
C19770	Molecular_Analysis	Molecular_Biology_Techniques	Molecular Analysis	Techniques for studying or analyzing the genetic composition and mechanisms of living organisms at the molecular level. May refer to the understanding and manipulation of genes (DNA). (NCI2005)
C19771	Molecular_Profiling	Molecular_Analysis	Molecular Profiling|Expression Profiling|Expression Signature|Molecular Fingerprinting	Molecular profiling studies utilize measurement of global mRNA and protein patterns towards identification of the individual genes and collections of genes that mediate particular aspects of cellular physiology and pathology. (from CGAP Molecular Profiling Initiative: What is Molecular Profiling? (see http://cgap-mf.nih.gov/)
C19772	NCI_Executive_Committee	NCI_Advisory_Boards_and_Groups	NCI Executive Committee
C19773	Office_for_Protection_from_Research_Risks	Component_of_the_National_Institutes_of_Health	Office for Protection from Research Risks|OPRR	The Office for Protection from Research Risks (OPRR) is organizationally located in the Office of the Director, NIH.  OPRR is charged with interpreting and overseeing implementation of the regulations regarding the Protection of Human Subjects codified at Title 45, Part 46, of the Code of Federal Regulations.  Also, OPRR is responsible for providing guidance on ethical issues in biomedical and behavioral research.  (http://helix.nih.gov:8001/ohsr/whatoprr.php3)
C19774	Office_of_Cancer_Survivorship	Component_of_the_Division_of_Cancer_Control_and_Population_Sciences	Office of Cancer Survivorship	The Office of Cancer Survivorship was established in 1996 to provide support and a focus for research and other activities dealing with cancer survivors. OCS workshops were held in 1996 and 1997 to define priorities for research, which included the prevalence of physical effects from cancer treatment, the prevalence of second cancers in survivors, quality of life, and quality and cost of follow-up care for survivors.
C19775	Pediatric_Cancer_Care_Network	Professional_Organization_or_Group	Pediatric Cancer Care Network	This network, a cooperative agreement among the Children's Cancer Group, the Pediatric Oncology Group, and the Blue Cross Blue Shield System Association (BCBS) nationwide, will ensure that children of BCBS subscribers receive care at designated centers of cancer care excellence and may promote the enrollment of children in Cooperative Group clinical trials.
C19776	Pediatric_Oncology_Group	Oncology_Group	Pediatric Oncology Group|POG	An NCI-sponsored clinical trials cooperative group of individuals and institutions dedicated to controlling cancer among children and adolescents. (http://www.pog.ufl.edu/)
C19777	Polyvalence	Physical_Phenomena_or_Properties	Polyvalence	The ability of a molecule such as an antibody to bind multiple related target molecules.  A polyvalent vaccine has the ability to elicit protection against multiple, closely related pathogens.
C19778	Radiation_Therapy_Oncology_Group	Clinical_Trials_Cooperative_Group	Radiation Therapy Oncology Group|RTOG	A multi-institutional cooperative organization, a national cancer study research group comprised of 250 of the major research institutions nationally and in Canada, funded by NCI, headquartered in Philadelphia with almost 30 years of experience in running clinical trials. More than 40 clinical trials that involve radiation therapy either alone or in conjunction with surgery and/or chemotherapeutic drugs are active at any one time within RTOG. The group is interested in quality of life issues and their effects on the cancer patient
C19779	Regulatory_Pathways	Biochemical_Pathway	Regulatory Pathway	An elaboration of the known or inferred interactions controlling the expression of a product.
C19780	Small_Animal_Imaging_Systems	Imaging_Technology	Small Animal Imaging Systems
C19781	Study_Section	Professional_Organization_or_Group	Study Section
C19782	Surveillance_Implementation_Group	Professional_Organization_or_Group	Surveillance Implementation Group|SIG	A group with the purpose to identify what cancer surveillance research is most needed and how best to advance our knowledge of cancer based on the opportunities available.  The SIG was charged with providing advice and recommendations for expanding and enhancing NCI's Cancer Surveillance Research Program.
C19783	Task_Force_on_Environmental_Health_Safety_Risks_to_Children	Professional_Organization_or_Group	Task Force on Environmental Health Safety Risks to Children
C19784	Tumor-Secreted_Protein	Protein_Organized_by_Origin	Tumor-Secreted Protein	Proteins or protein fragments secreted from, or shed by, tumor cells.
C19785	Uncertain_Risk	Risk_Estimate	Uncertain Risk
C19786	Research_Career_Programs_K-Series	Funding_Mechanisms	Research Career Programs, K-Series|Career Development Awards|Career Development Awards and Programs|Career Development Programs K-Series|K-Awards|Research Career Program|Research Career Programs	Grants designated with a K prefix and awarded to researchers who have a doctorate to develop their careers as independent scientists.  Length of award can be from three and up to five years.  Some are mentored the entire period whereas others are mentored partially or entirely unmentored.
C19787	Warren_G_Magnuson_Clinical_Center	Component_of_the_National_Institutes_of_Health	Warren G. Magnuson Clinical Center
C19788	Population_Scientist_Supplement	Continuing_Umbrella_of_Research_Experience_for_Underserved_Minorities_Program|Training_Program_for_Cancer_Prevention_and_Control_Scientists	Population Scientist Supplement (R25)|R25 Award
C19789	Underrepresented_Minority	Minority_Group	Underrepresented Minority|Underrepresented Minorities	Underrepresented Minority; any minority group presently underrepresented in biomedical and behavioral research.
C19790	Tumor_Subtype	Cancer_Histology	Tumor Subtype
C19791	Cancer_Prevention_Control_and_Population_Sciences_Career_Development_Award_K07	Academic_Teacher_Award	Cancer Prevention, Control and Population Sciences Career Development Award (K07)|K07 Award|Preventive Oncology Career Development Award (K07)
C19792	Program_Reviews	Document_Type	Program Reviews
C19793	Training_Program_for_Cancer_Prevention_and_Control_Scientists	Education_Projects	Training Program for Cancer Prevention and Control Scientists (R25)|Cancer Education and Career Development Program|Cancer Education and Career Development Program (R25)|R25T Award
C19794	Therapeutic_Studies	Research_Funding_Categories	Therapeutic Studies|Therapy Research
C19795	Societal_Factors	Epidemiological_Factors	Societal Factors	The consideration of societal factors as variables in disease incident, transmission, and control.
C19796	Smoking_Status	Personal_Attribute	Smoking Status
C19797	Chromatin_Remodeling	Chromatin_Structure_Alteration	Chromatin Remodeling	Chromatin Remodeling involves alterations of the content or activity of DNA-binding and chromatin-associated proteins that affect the function and higher order conformational state of chromatin, as well as the activity of specific genes or functional DNA regions.
C19798	Splice-Site_Mutation	Gene_Mutation	Splice-Site Mutation|Splice-Juction Mutation|Splice-Junction Mutation	Splice-Site Mutation is a permanent and heritable change in the nucleotide sequence of a splice site in a gene.
C19799	DRD2-A1_Allele	DRD2_Gene	DRD2 A1 Allele|Dopamine Receptor D2 A1 Allele	Human DRD2 Gene at 11q23 encodes Dopamine Receptor D2, a G-protein coupled receptor that inhibits adenylyl cyclase activity. Missense mutation in DRD2 causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing results in two different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. Different alleles are associated with increased incidence of substance abuse. The A1 allele has been associated with alcoholism. (NCI)
C19800	Yeast_Protein_Complex	Yeast_Protein	Yeast Protein Complex
C19801	NURF	Drosophila_Protein_Complex	NURF|Nucleosome Remodeling Factor	The Drosophila NURF complex catalyzes nucleosome sliding.  The Nurf301 subunit contains a bromodomain transcription factor domain, a zinc finger binding domain, nuclear localization signals, and motifs associated with rapid protein degradation.  The HMGA/HMGI(Y)-like domain of Nurf301 facilitates nucleosome sliding.  Nurf301 also interacts with sequence-specific transcription factors, providing a basis for targeted recruitment of the NURF complex to specific genes.  (from OMIM 601819, SWISS-PROT Q24572, O77460, Q24368, and NCI)
C19802	RSC	Yeast_Protein_Complex	RSC|Remodels the Structure of Chromatin	RSC is an abundant fifteen-protein chromatin remodeling complex containing SNF12 [RSC6p subunit homologue], RSC1 (or RSC2 or RSC4), RSC58 [58 kD subunit], and SFH1.  (from SGD and NCI)
C19803	SWI2-SNF2_Protein	Yeast_Protein	SWI2/SNF2|Mating Type Switch 2/Sucrose Nonfermenting 2|Regulatory Protein GAM1|Regulatory Protein SWI2|SWI/SNF Complex Component SNF2|Snf2p|Swi2p|Transcription Factor TYE3|Transcription Regulatory Protein SNF2	Nuclear SWI2/SNF2 (SNF2/RAD54 Helicase Family) is a 1703-aa, 194-kD general RNA polymerase II transcription regulator component of the SWI/SNF nucleosome/chromatin remodeling complex involved in global transcriptional activation of induced gene expression and coordinate regulation of phospholipid synthesis. This complex alters chromatin structure to facilitate binding of gene-specific transcription factors. Containing a bromodomain domain and three AT Hook DNA-binding repeats, SWI2/SNF2 exhibits strong similarity to Drosophila brahma. (from Swiss-Prot, and NCI)
C19804	SAGA	Yeast_Protein_Complex	SAGA|SPT/ADA/Gcn5 Acetyltransferase	One of two transcriptional adaptor/HAT (histone acetyltransferase) complexes, SAGA includes SPT8, ADA2, NGG1, SPT20 (or SPT3 or SPT7), SGF29 [29 kD subunit], SGF73 [73 kD subunit].  (from SGD and NCI)
C19805	CHRAC	Drosophila_Protein_Complex	CHRAC|Chromatin Accessibility Complex	The Drosophila gene Chrac-14 encodes a component of the chromatin accessibility complex.  It contains a histone-fold/TFIID-TAF/NF-Y domain. Similar sequences have been identified in Schizosaccharomyces pombe.  The Drosophila gene Chrac-16 also encodes a component of the chromatin accessibility complex.  (from FlyBase 0043002, 0043001, and NCI)
C19806	Model_Genes_and_Proteins	Retired_Concepts	Model Genes and Proteins
C19807	SWI1	Protein_Complex_Subunit	SWI1|Mating Type Switch 1|Swi1/Adr6|Switch 1	A component of the SWI/SNF global transcription activator complex, SWI1 acts in complex with Snf2p, Snf5p, Snf6p, and Swi3p to assist gene-specific activators through nucleosome/chromatin remodeling. SWI1 is involved in the regulation of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2.  The SWI/SNF complex is required for induced expression of many genes and alters chromatin structure to facilitate binding of gene-specific dedicated transcription factors.  A zinc finger non-specific RNA polymerase II transcription factor, SWI1 contains an ARID domain.  (from SWISS-PROT P09547, SGD S0005937, and NCI)
C19808	Swi3p	Yeast_Protein	Swi3p|Mating Type Switch 3|SWI/SNF Complex Component Swi3p|SWI3|Switch 3|Transcription Factor TYE2|Transcription Regulatory Protein Swi3|Transcription Regulatory Protein Swi3p	Nuclear Swi3p is an 825-aa, 93-kD general RNA polymerase II transcription factor component of the SWI/SNF nucleosome/chromatin remodeling complex involved in global transcriptional activation of induced gene expression. This complex alters chromatin structure to facilitate binding of gene-specific transcription factors. Swi3p contains a MYB-like domain and interacts with the N-terminus of SNF2. (from Swiss-Prot, SGD, and NCI)
C19809	SNF6	Yeast_Protein	SNF6|Sucrose Nonfermenting 6	A component of the SWI/SNF global transcription activator complex, SNF6 assists gene-specific activators through nucleosome/chromatin remodeling.  The SWI/SNF complex is required for induced expression of many genes and alters chromatin structure to facilitate binding of gene-specific dedicated transcription factors.  SNF6 is a non-specific RNA polymerase II transcription factor.  (from SWISS-PROT P18888, SGD S0001017, and NCI)
C19810	DRD2-A2_Allele	DRD2_Gene	DRD2 A2 Allele|Dopamine Receptor D2 A2 Allele	Human DRD2 Gene at 11q23 encodes Dopamine Receptor D2, a G-protein coupled receptor that inhibits adenylyl cyclase activity. Missense mutation in DRD2 causes myoclonus dystonia; other mutations have been associated with schizophrenia. Alternative splicing results in two different isoforms. A third variant has been described, but it has not been determined whether this form is normal or due to aberrant splicing. Different alleles are associated with increased incidence of substance abuse. (NCI)
C19811	Second_Degree_Relative	Relative	Second Degree Relative	Any relative who is two meioses away from a particular individual in a family; a relative with whom one quarter of an individual's genes is shared (i.e., grandparent, grandchild, uncle, aunt, nephew, niece, half-sibling) (from Genetics Home Reference glossary)
C19812	Xenograft_Model	Animal_Model	Xenograft Model	Describes to xenografts (implanting tissue or cell lines from a different species) and allografts (implanting tissue or cell lines form the same species). The grafts are transplanted in immuno-compromised animals where they grow and, depending on the graft material, form tumors.
C19813	Immunoliposome	Liposome	Immunoliposome	Liposomes that are coated with antibodies for delivery to specific targets.
C19814	Drosophila_Protein_Complex	Drosophila_Protein	Drosophila Protein Complex
C19815	TdT-Mediated_dUTP_Nick_End_Labeling_Assay	Molecular_Biology_Techniques	TdT-Mediated dUTP Nick End Labeling Assay|TUNEL Assay	A method to detect apoptosis.
C19816	G1_Arrest	Cell_Cycle_Arrest	G1 Arrest|G1 Block	G1 Arrest consists of cellular biochemical mechanisms, responsive to diverse governing conditions (DNA damage, contact inhibition, growth factors, etc.), that control cellular progress through the G1 phase of the cell cycle. G1 progress is controlled by de/phosphorylated cyclin/CDK complexes. During G1, cycD/CDK phosphorylation of Rb/HDAC repressor permits E2F/DP1 transcription of genes that promote the G1/S switch and DNA replication. p53 induces p21 inhibition of cycD/CDK; Mdm2 inhibits p53/p21. TGF-b induces p15 inhibition of cycD/CDK. cAMP induces p27 inhibition of cycD/CDK. GSK3b induction of cycD degradation, and INK4, Kip, and Cdc25A regulate cycD/CDK activity.
C19817	HSV-Tk_Gene	Viral_Gene	HSV-Tk Gene|HSV-Tk|Herpes Simplex Virus Thymidine Kinase Gene	Herpes simplex virus thymidine kinase (HSV-Tk) gene encodes thymidine kinase protein, which is important for herpes simplex virus infection. The TK gene and promoter are widely used in genetic research because of the easily selectable phenotype.
C19818	Cellular_Retinoic_Acid_Binding_Protein	Ligand_Binding_Protein	Cellular Retinoic Acid Binding Protein|CRABP	Cellular Retinoic Acid-Binding Proteins are assumed to play an important role in retinoic acid-mediated differentiation and proliferation processes.  Cytoplasmic CRABP-I and CRABP-II may regulate access of retinoic acid to nuclear retinoic acid receptors.  CRABP-II may participate in a regulatory feedback mechanism to control the action of retinoic acid on cell differentiation.  CRABP-I and CRABP-II belong to the FABP/P2/CRBP/CRABP family of transporters.  (from OMIM 180230, 180231, SWISS-PROT P29762, P29373, and NCI)
C19819	cDNA_Array	DNA_Microarray_Chip	cDNA Array|cDNA Microarray	A molecular biology device that utilizes a set of defined cDNA clones attached in a specific grid arrangement to a solid support for nucleic acid hybridization assays in gene mapping studies or in determining gene sequences, sequence variations, or gene expression patterns.
C19820	Warburg_Effect	Tumor-Associated_Process	Warburg Effect	This effect refers to the high cellular levels of lactic acid in tumor cells, and is named after Otto Warburg who worked on photosynthesis.  Tumor cells use excessive glucose in their rapid growth, and lactic acid is a product of the glycolytic pathway.  This process is not inhibited by oxygen, therefore, it is also called aerobic glycolysis.
C19821	CpG_Island_Methylator_Phenotype	Phenotype	CpG Island Methylator Phenotype|CIMP|CIMP+	A phenotype whereby a subset of tumors are characterized by the simultaneous hypermethylation of multiple promoter-associated CpG islands.
C19822	Allelotyping	Molecular_Biology_Techniques	Allelotyping
C19823	Allelotype_Analysis	DNA_Analysis	Allelotype Analysis
C19824	Polyamine_Catabolism	Catabolism	Polyamine Catabolism	Polyamine Catabolism is a destructive metabolic process in which low molecular weight cations, containing two or more amine groups (polyamines), are converted into excreted compounds.
C19825	Epithelial_Cell_Aggregation_and_Separation	Cytological_Techniques	Epithelial Cell Aggregation and Separation|EASI	A method for rapidly obtaining near-pure aggregates of epithelial cell populations.  Smears are prepared, rapidly fixed in methanol and stained.  Microscopic examination permits precise identification of epithelial cell aggregates for separation by laser capture microdissection.
C19826	Short_Oligonucleotide_Mass_Analysis	Mass_Spectrometry|Polymorphism_Analysis	Short Oligonucleotide Mass Analysis	A method to produce defined small DNA fragments from PCR products for analysis of DNA variations by mass spectrometry. (from 7th SPORE Investigators' Workshop)
C19827	Brightfield_Microscopy	Light_Microscopy	Brightfield Microscopy|Brightfield Analysis	Brightfield microscopy is a type of light microscopy in which objects are seen against a bright background.
C19828	Metaphase_Spread	Cytogenetic_Analysis	Metaphase Spread	Analysis of chromosomes arrested during metaphase. The chromosomes are highly condensed at this stage of cell division and are visible under a light microscope. (From the journal Nature-Glossary).
C19829	G2-M_Arrest	Cell_Cycle_Arrest	G2/M Arrest	G2/M Arrest consists of cellular biochemical mechanisms, responsive to diverse conditions, that control cellular transition from the G2 to M phase of the cell cycle. Cdc2/cycB regulates this transition. During G2, Cdc2 is inactivated by Wee1 and Mt1 kinases. Activation of Cdc25 phosphatase activates Cdc2. If genome damage has occurred, activated DNA-PK/ATM/ATR kinases inactivate Cdc2/cycB by two channels. First, Cdc25 is inactivated by CHK kinases. Second, phosphorylated p53 dissociates from MDM2, is acetylated by p300/PCAF, binds DNA, and activates transcription of genes that inhibit Cdc2/cyclin (14-3-3s, GADD45, and p21Cip1).
C19830	Co-Immunoprecipitation	Immunoprecipitation	Co-Immunoprecipitation	Co-immunoprecipitation (Co-IP) is a popular technique for protein interaction discovery. In a co-IP the target antigen precipitated by the antibody "co-precipitates" a binding partner/protein complex from a lysate. It is assumed that these proteins are related to the function of the target antigen at the cellular level.
C19831	Tissue_Recombination	Research_Techniques	Tissue Recombination	A technique used in developmental biology to investigate the effects of one tissue upon another in induction of differentiation and tissue and organ formation.  Basically, a piece of tissue is transplanted from its normal location to a new location.  This helps to distinguish between intrinsic and extrinsic influences in organ formation.
C19832	Nuclear_Extract	Specimen	Nuclear Extract	Nuclear extracts contain proteins in nuclear compartment of the cell and are used to monitor transcription factor activation in a variety of standard protocols, including electrophoresis mobility shift assay (EMSA), DNA footprinting, Western blotting and preparative purification of nuclear proteins.
C19833	Dorsal_Skinfold_Window_Chamber_Model	Animal_Model	Dorsal Skinfold Window Chamber Model	Observation chambers, implanted in various animal species and in man, used for intravital microscopy of the microcirculation in granulation tissue, preformed tissue, or of the microvascularization of tissue implants.
C19834	Matrigel_Artificial_Basement_Membrane_Model	in_vitro_Model	Matrigel Artificial Basement Membrane Model
C19835	Gelatin_Zymography	Sodium_Dodecylsulfate-Polyacrylamide_Gel_Electrophoresis	Gelatin Zymography|Gelatin Substrate Zymography	An SDS-PAGE based technique used to identify matrix metalloproteinases.
C19836	Cytosolic_Phospholipase-A2	Phospholipase-A2	Cytosolic Phospholipase A2|Cytosolic Phospholipase A2 Group IV|Cytosolic Phospholipase A2G4|Cytosolic Phospholipase A2IV|Phospholipase A2G4|Phospholipase A2IV|cPLA2	Cytosolic phospholipase A2 is involved in cell cycle progression via regulation of arachidonic acid metabolism. (Cell Mol Life Sci 2002;59:181-8)
C19837	hSWI-SNF_Protein	Protein_or_Riboprotein_Complex	hSWI/SNF|Human SWI/SNF	hSWI/SNF is an ATP-dependent chromatin-remodeling complex implicated in the regulation of gene expression, cell cycle control, and oncogenesis. The complex facilitates transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Subunits of the complex include: BAF57, BAF60a,-b,-c, BAF155, BAF170, BRG-1, BRM, and hSNF5/INI1. BAF57 contains an HMG domain adjacent to a kinesin-like region and binds DNA. BAF155 and BAF170 are BRG-1-associated proteins with dimerization motifs for transcription factors. BRM and BRG-1 are ATPase subunits of the complex and co-activators for nuclear hormone receptors. BRG-1 interacts with BRCA1, a nuclear phosphoprotein transcription and recombination accessory factor.
C19838	BAF155	Protein_Complex_Subunit	BAF155|BRG-1-Associated Factor, 155-kDa|CRACC1|Chromatin Remodeling Complex BAF155 Subunit|Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 155|Mammalian Chromatin Remodeling Complex, BRG1-Associated Factor 155|Rsc8|SMARCC1|SRG3|SWI/SNF Complex 155 kDa Subunit|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily C, Member 1|SWI3|SWI3 Homolog	A subunit of the hSWI/SNF complex and homolog of yeast SWI3. BAF155 contains a predicted leucine zipper region (dimerization motif for many transcription factors) and a myb-like tryptophan-repeat domain. (from OMIM 601732 and NCI)
C19839	BAF170	Protein_Complex_Subunit	BAF170|BRG-1-Associated Factor, 170-kDa|Chromatin Remodeling Complex BAF170 Subunit|Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 170|SMARCC2|SWI/SNF Complex 170 kDa Subunit|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily C, Member 2|SWI3 Homolog	A subunit of the hSWI/SNF complex and homolog of yeast SWI3. BAF170 contains a predicted leucine zipper region (dimerization motif for many transcription factors) and a myb-like tryptophan-repeat domain. (from OMIM 601734 and NCI)
C19840	BAF57	Protein_Complex_Subunit	BAF57|BRG-1-Associated Factor, 57-kDa|BRG1-Associated Factor, 57-kD|Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 57|SMARCE1|SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily E, Member 1|SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator of Chromatin E1	A subunit of the hSWI/SNF complex that contains an HMG domain and a kinesin-like region. BAF57 has DNA-binding characteristics similar to other HMG proteins. (from OMIM 603111 and NCI)
C19841	SWP73	Yeast_Protein	SWP73|Snf12|Swp73/Snf12	A 73 kD subunit of the SWI/SNF global transcription activator complex, SWP73 assists gene-specific activators through nucleosome/chromatin remodeling.  The SWI/SNF complex is required for induced expression of many genes and alters chromatin structure to facilitate binding of gene-specific dedicated transcription factors.  SWP73 is a non-specific RNA polymerase II transcription factor and homologue of Rsc6p subunit of the RSC chromatin remodeling complex with similarity to yeast ycr52w.  (from SGD S0005306 and NCI)
C19842	BAF60A	Protein_Complex_Subunit	BAF60A|BRG1-Associated Factor 60A|BRG1-Associated Factor A, 60-KD|CRACD1|Chromatin Remodeling Complex BAF60A Subunit|Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 60A|Mammalian Chromatin Remodeling Complex, BRG1-Associated Factor 60A|Rsc6|Rsc6p|SMARCD1|SWI/SNF Complex 60 kDa Subunit A|SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin Subfamily D Member 1|SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 1|SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator of Chromatin D1|SWP73 Homolog|SWP73, Yeast, Homolog of|Swp73-Like Protein	A subunit of the hSWI/SNF complex and homologous to yeast SWP73. (from OMIM 601735 and NCI)
C19843	BAF60b	Protein_Complex_Subunit	BAF60b|BRG1-Associated Factor B, 60-KD|Chromatin Remodeling Complex BAF60B Subunit|Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 60B|SMARCD2|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily D, Member 2|SWP73 Homolog	A subunit of the hSWI/SNF complex and homologous to yeast SWP73. (from OMIM 601736 and NCI)
C19844	BAF60C	Protein_Complex_Subunit	BAF60C|BRG1-Associated Factor C, 60-kD|CRACD3|Chromatin Remodeling Complex BAF60C Subunit|Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 60C|Mammalian Chromatin Remodeling Complex, BRG1-Associated Factor 60C|Rsc6p|SMARCD3|SWI/SNF Complex 60 kDa Subunit C|SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 3|SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator of Chromatin D3|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily D, Member 3|SWP73 Homolog|SWP73 Yeast, Homolog of|Swp73-Like Protein	A subunit of the hSWI/SNF complex and homolog of yeast SWP73. (from OMIM 601737 and NCI)
C19845	BRG1_Protein	SWI2-SNF2_Family_Protein	BRG1 Protein|BRG-1|BRG-1 Protein Mitotic Growth and Transcription Activator|BRG-1/SNF2beta|BRG1|BRM/SWI2-Related Protein 1|Brahma Protein Homolog 1|Possible Global Transcription Activator SNF2L4|SMARCA4|SNF2beta|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 4	An SNF2/RAD54 helicase family member. Containing 1 bromodomain, BRG-1 is a co-activator for nuclear hormone receptors. (from SWISS-PROT P51532 and NCI)
C19846	hBRM	SWI2-SNF2_Family_Protein	hBRM|BRM Homolog|BRM/SNF2alpha|Human Brahma|Possible Global Transcription Activator SNF2L2|SNF2-Like 2|SNF2/SWI2 Homolog|SNF2L2|SNF2LA|SNF2alpha|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 2|Smarca2|Sucrose Nonfermenting Homolog-Like 2	An ATPase subunit of the SWI/SNF enzyme, BRM belongs to the SNF2/RAD54 helicase family, contains a bromodomain, and is a co-activator for nuclear hormone receptors.  BRM is a yeast transcription factor SWI2 homologue. Nuclear BRM is phosphorylated, excluded from condensed chromosomes, and strongly reduced during mitosis; phosphorylation does not disrupt the association with SNF5, but correlates with decreased affinity for the nuclear structure in early M-phase.  SWI/SNF enzymes promote MyoD-mediated muscle differentiation by altering chromatin structure in promoter regions of differentiation-specific loci.  (from SWISS-PROT P51531, OMIM 600014, and NCI)
C19847	SWP82	Yeast_Protein	SWP82	SWP82, around 82 KD, is one of the subunits of SWI/SNF complex from S. cerevisiae.
C19848	SWP61	Yeast_Protein	SWP61|ARP7|Actin-Related Protein 7|RSC11	A component of the SWI/SNF global transcription activator complex and the RSC chromatin remodeling complex, SWP61 assists gene-specific activators through nucleosome/chromatin remodeling.  The SWI/SNF complex is required for induced expression of many genes and alters chromatin structure to facilitate binding of gene-specific dedicated transcription factors.  Actin-related SWP61 is a non-specific DNA-binding RNA polymerase II transcription factor.  (from SGD S0006238 and NCI)
C19849	SWP59	Yeast_Protein	SWP59|ARP9|Actin-Related Protein 9|RSC12	A component of the SWI/SNF global transcription activator complex and the RSC chromatin remodeling complex, SWP59 assists gene-specific activators through nucleosome/chromatin remodeling.  The SWI/SNF complex is required for induced expression of many genes and alters chromatin structure to facilitate binding of gene-specific dedicated transcription factors.  Actin-related SWP59 is a non-specific DNA-binding RNA polymerase II transcription factor ATPase.  (from SGD S0004636 and NCI)
C19850	SWP29	Yeast_Protein	SWP29|ANC1|TAF30|TAFII3|TFG3/TAF30/ANC1|Tfg3	Interacts with SNF5. Not required for DNA-dependent ATPase activity of SWI complex (10). Also part of TFIID and TFIIF complexes (10). Related to MLL translocation partners AF-9 and ENL.
C19851	Basal_Transcription_Factor	Transcription_Factor	Basal Transcription Factor|General Transcription Factor	Basal Transcription Factors are prokaryotic and eukaryotic proteins that cooperate with DNA-dependent RNA polymerases to initiate, inhibit or terminate transcription.
C19852	dSWI-SNF_Protein	Drosophila_Protein_Complex	dSWI/SNF|Drosophila SWI/SNF
C19853	SWI2-SNF2_Family_Protein	Transcription_Regulatory_Protein	SWI2/SNF2 Family Protein	SWI2/SNF2 family proteins possess ATP-dependent chromatin remodeling activity that influences gene expression.
C19854	Swh3p	Yeast_Protein	Swh3p|Rsc8|Rsc8/Swh3|Swh3|YFR037C	A subunit of unknown function in the fifteen-protein RSC nucleosome/chromatin remodeling complex, Rsc8/Swh3 is a homolog of the SWI/SNF protein SWI3. Swi3/BAF155 contains a leucine zipper motif typical of many transcription factors. Swh3p undergoes dimerization via the coiled-coil C-terminus, forms a complex with RSC6p, interacts with the SWI2/SNF2 ATPase Sth1p, and appears to mediate multiple RSC interactions. SWI/SNF and RSC share conserved components. SWI/SNF proteins display helicase and ATPase activities and appear to regulate gene transcription by altering local chromatin structure. RSC complex is required for transcriptional regulation and nucleosome positioning. RSC maintains a repressive chromatin structure at certain inducible promoters. (from SGD; NAR 26:3739, 1998; EMBO J. 18:2836, 1999; and NCI)
C19855	Sth1p	Yeast_Protein	Sth1p|Nps1p|Sth1p/Nps1p	A DNA helicase component of the abundant RSC chromatin remodeling complex, Sth1p has a bromodomain and belongs to the SNF2/RAD54 helicase family.  Sth1p is essential for mitotic growth and meiosis and is involved in G2 phase control.  (from SWISS-PROT P32597, SGD S0001388, and NCI)
C19856	SNR1	Drosophila_Protein	SNR1|Snf5-Related 1	The Drosophila gene Snf5-related 1 (Snr1) encodes a non-specific RNA polymerase II transcription factor.  It interacts genetically with brm, trx, and osa.  Similar sequences have been identified in Caenorhabditis elegans, Homo sapiens, Saccharomyces cerevisiae, and Tetraodon fluviatilis. (from FlyBase 0011715 and NCI)
C19857	SNF2L1	SWI2-SNF2_Family_Protein	SNF2L1|Human SNF2-Like|SMARCA1|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 1|Sucrose Nonfermenting, Yeast, Homolog-Like 1|hSNF2L	This protein is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes.
C19858	SNF2H	SWI2-SNF2_Family_Protein	SNF2H|SMARCA5|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 5	This protein is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. This protein is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. It is similar in sequence to the Drosophila ISWI chromatin remodeling protein.
C19859	SNF11	Yeast_Protein	SNF11|Sucrose Nonfermenting 11	SNF11is involved in transcriptional activation as a component of the SWI/SNF global transcription activator complex, required for the induced expression of a large number of genes by altering chromatin structure to facilitate binding of gene-specific transcription factors.  (from SWISS-PROT P38956 and NCI)
C19860	Sfh1	Yeast_Protein	Sfh1|Sfh1p	Sfh1 is a subunit (of unknown molecular function) of the abundant RSC complex, a fifteen-protein nucleosome/chromatin remodeling complex related to the SWI/SNF complex.  Involved in chromatin modeling and cell cycle progression, Sfh1 is an Snf5p homologue with similarity to Sec14p.  (from SGD S0004313 and NCI)
C19861	Rsc6	Retired_Concepts	Rsc6|Rsc6p	Rsc6 is a subunit (of unknown molecular function) of the abundant RSC complex, a fifteen-protein nucleosome/chromatin remodeling complex related to the SWI/SNF complex.  (from SGD S0000648 and NCI)
C19862	OSA	Drosophila_Protein	OSA	The Drosophila gene osa encodes a putative DNA binding protein that contains an AT-rich interaction domain (ARID).  It interacts genetically with Antp, ro, brm, Pc, Scr, and several other genes.  Similar sequences have been identified in Caenorhabditis elegans, Homo sapiens, Mus musculus, and Saccharomyces cerevisiae.  (from FlyBase 0003013 and NCI)
C19863	MOIRA_Gene_Product	Drosophila_Protein	MOIRA Gene Product|MOIRA|MOR	The Drosophila gene moira (mor) encodes a non-specific RNA polymerase II transcription factor involved in chromatin modeling, which is a component of the nucleosome remodeling complex.  It contains a MYB DNA binding domain and interacts genetically with Antp, Pc, Dfd, Scr, ph-p, and other genes.  Similar sequences have been identified in Homo sapiens, Mus musculus, Saccharomyces cerevisiae, and Schizosaccharomyces pombe.  (from FlyBase 0002783 and NCI)
C19864	Mediator_of_Activation	Yeast_Protein_Complex	Mediator of Activation|Mediator	Mediator of Activation is a component of the RNA polymerase II holoenzyme and mediator subcomplex.  (from SGD S0001100 and NCI)
C19865	BRAHMA	Drosophila_Protein	BRAHMA|BRM	The Drosophila gene brahma (brm) encodes a non-specific RNA polymerase II transcription co-activator, assisting one or more transcriptional activators of ANT-C and BX-C homeotic genes.  Brm can counteract the repressive effect of polycomb protein and exhibits DNA-dependent ATPase activity.  It contains a SNF2 related domain, a DEAD/DEAH box helicase, a helicase C-terminal domain, and belongs to the SNF2/RAD54 helicase family.  Two isoforms (long and short) may be produced by alternative splicing.  Highest expression is seen in unfertilized eggs and early embryos.  It interacts genetically with Antp, trx, Psc, Pc, hh, and several other genes.  Similar sequences have been identified in Caenorhabditis elegans, Gallus gallus, Homo sapiens, Mus musculus, and Saccharomyces cerevisiae.  (from SWISS-PROT P25439, FlyBase 0000212, and NCI)
C19866	PRC1	Drosophila_Protein_Complex	PRC1|PRC1 Protein|Polycomb Repressive Complex 1	PRC1 (Polycomb repressive complex 1) contains the products of the PcG genes Polycomb, Posterior sex combs, polyhomeotic, Sex combs on midleg, and several other proteins.  Preincubation of PRC1 with nucleosomal arrays blocks the ability of these arrays to be remodeled by SWI/SNF.  PRC1 and SWI/SNF are likely compete with each other for the nucleosomal template.
C19867	Polycomb	Drosophila_Protein	Polycomb	The Drosophila gene Polycomb (Pc) encodes a transcriptional repressor required for the segment-specific repression of homeotic selector genes by promoting locus-specific chromatin compaction.  Pc may be involved in the stable transmission of a determined state by its effects on chromatin structure.  It contains one chromo domain and interacts genetically with ph-p, Antp, E(Pc), Pcl, Asx, and many other genes.  Similar sequences have been identified in African clawed frog, Caenorhabditis elegans, Homo sapiens, and Mus musculus.  (from SWISS-PROT P26017, FlyBase 0003042, and NCI)
C19868	Polyhomeotic	Drosophila_Protein	Polyhomeotic	The Drosophila 'Polycomb' group (PcG) proteins form a large multimeric, chromatin-associated complex, repress gene expression, and are part of a system responsible for stable inheritance of gene activity. Polyhomeotic may interact with proteins bound to promoter complexes and negatively regulate homeotic and segmentation genes, and regulate the expression of other pair-rule genes such as EVE, FTZ, and H. The Drosophila PcG protein, polyhomeotic (Ph), contains a SAM domain and shares several motifs with mouse Rae28 protein.  Rae28, Mel18, M33, and Bmi1 are components of a mouse multimeric protein complex. Human HPH1, HPH2, and BMI1 also appear to be part of a multimeric protein complex. HPH2 interacts with BMI1.  Rae28/Mph1, HPH1, HPH2, and Ph share homology in the zinc finger domain and in homology domains I and II.  Homology domains I and II may mediate the heterodimerization interactions of HPH1 and HPH2. (from OMIM, SWISS-PROT and NCI)
C19869	Posterior_Sex_Combs_Protein	Drosophila_Protein	Posterior Sex Combs	The Drosophila gene Posterior Sex Combs (Psc) encodes a ring-type zinc finger DNA binding protein (Polycomb group) involved in negative regulation of expression patterns of the antennapedia and bithorax homeotic selector gene complexes, and hence maintenance of segmental determination.  Similar sequences have been identified in Homo sapiens and Mus musculus.  Psc interacts genetically with z, brm, Sce, mxc, Asx, and several other genes.  Mutations in Psc generate malformations of the longitudinal tracts.  (from SWISS-PROT P35820, FlyBase 0005624, and NCI)
C19870	Sex_Combs_on_Midleg_Protein	Drosophila_Protein	Sex Combs on Midleg
C19871	E-RC1	Protein_or_Riboprotein_Complex	E-RC1|EKLF Coactivator-Remodeling Complex 1	A chromatin-remodeling complex that contains the BRG1, BAF170, BAF155, and INI1 homologs of yeast SWI/SNF subunits, as well as a unique subunit, BAF57. E-RC1 appears to be critical for chromatin remodeling and Beta-Globin transcription by EKLF.
C19872	SMARCC1_Gene	Protein_Complex_Subunit_Gene|SWI-SNF-Related_Gene	SMARCC1 Gene|BAF155|BAF155 Gene|CRACC1 Gene|Chromatin Remodeling Complex BAF155 Subunit Gene|Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 155 Gene|Mammalian Chromatin Remodeling Complex, BRG1-Associated Factor 155 Gene|Rsc8 Gene|SMARCC1|SRG3 Gene|SWI/SNF Complex 155 kDa Subunit Gene|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily C, Member 1 Gene|SWI3 Gene	The SMARCC1 Gene at 3p23-p21 encodes BAF155, which is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. (From LocusLink and NCI)
C19873	SMARCC2_Gene	Protein_Complex_Subunit_Gene|SWI-SNF-Related_Gene	SMARCC2 Gene|BAF170 Gene|BRG1-Associated Factor, 170-kD Gene|CRACC2 Gene|Chromatin Remodeling Complex BAF170 Subunit Gene|Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 170 Gene|Mammalian Chromatin Remodeling Complex, BRG1-Associated Factor 170 Gene|Rsc8 Gene|SMARCC2|SWI/SNF Complex 170 kDa Subunit Gene|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily C, Member 2 Gene|SWI3-Like Protein Gene	The SMARCC2 Gene at 12q13-q14 encodes BAF170, which is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Two transcript variants encoding different isoforms have been found for this gene. (From LocusLink and NCI)
C19874	SMARCE1_Gene	Protein_Complex_Subunit_Gene|SWI-SNF-Related_Gene	SMARCE1 Gene|BAF57 Gene|BRG1-Associated Factor, 57-kD Gene|Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 57 Gene|SMARCE1|SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily E, Member 1 Gene|SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator of Chromatin E1 Gene	Human BAF57 Gene encodes a ubiquitous protein, BAF57, a BRG1-associated subunit of the transcription-promoting hSWI/SNF chromatin-remodeling complex.  The SWI/SNF complex in S. cerevisiae and Drosophila appears to facilitate transcriptional activation of some genes by antagonizing chromatin-mediated transcriptional repression.  Functionally related to SWI/SNF, the mammalian BAF complex consists of nine to twelve subunits, some homologous to SWI/SNF subunits. The mechanism by which mammalian SWI/SNF-like complexes interact with chromatin may involve recognition of higher-order chromatin structure by two or more DNA-binding domains.  BAF57 and the BAF complex appear to bind DNA as it enters or exits the nucleosome.  ATP-dependent nucleosome disruption by the complex enhances transcription factor binding. (from OMIM and NCI)
C19875	SMARCD1_Gene	Protein_Complex_Subunit_Gene|SWI-SNF-Related_Gene	SMARCD1 Gene|BAF60A Gene|BRG1-Associated Factor 60a Gene|BRG1-Associated Factor A, 60-kD Gene|CRACD1 Gene|Chromatin Remodeling Complex BAF60A Subunit Gene|Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 60A Gene|Mammalian Chromatin Remodeling Complex, BRG1-Associated Factor 60A Gene|Rsc6p Gene|SMARCD1|SWI/SNF Complex 60 kDa Subunit A Gene|SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin Subfamily D Member 1 Gene|SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 1 Gene|SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator of Chromatin D1 Gene|Swp73-Like Protein Gene	Human BAF60a Gene (SWI/SNF family) at 12q13-q14 encodes BAF60a, a subunit of the transcription-promoting SWI/SNF chromatin-remodeling complex and homologue of yeast SWP73. BAF60a is similar to BAF60b and BAF60c.  Chromatin remodeling of some genes appears to precede transcriptional activation.  In yeast, the multisubunit SWI/SNF complex is thought responsible for chromatin remodeling.  Human SWI/SNF is composed of nine to twelve BAF polypeptides. (from OMIM and NCI)
C19876	SMARCD2_Gene	SWI-SNF-Related_Gene	SMARCD2 Gene|BAF60b Gene|SMARCD2|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily D, Member 2 Gene	Human BAF60b Gene (SWI/SNF family) at 17q23-q24 encodes BAF60b, a polypeptide subunit of the transcription-promoting SWI/SNF chromatin-remodeling complex and homologue of yeast SWP73.  BAF60b is similar to BAF60a and BAF60c.  Chromatin remodeling of some genes appears to precede transcriptional activation.  In yeast, the multisubunit SWI/SNF complex is thought responsible for chromatin remodeling.  Human SWI/SNF is composed of nine to twelve BAF polypeptides. (from OMIM and NCI)
C19877	SMARCD3_Gene	SWI-SNF-Related_Gene	SMARCD3 Gene|BAF60c Gene|BRG1-Associated Factor C, 60-kD Gene|CRACD3 Gene|Chromatin Remodeling Complex BAF60C Subunit Gene|Mammalian Chromatin Remodeling Complex BRG1-Associated Factor 60C Gene|Mammalian Chromatin Remodeling Complex, BRG1-Associated Factor 60C Gene|Rsc6p Gene|SMARCD3|SWI/SNF Complex 60 kDa Subunit C Gene|SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily D, Member 3 Gene|SWI/SNF-Related Matrix-Associated Actin-Dependent Regulator of Chromatin D3 Gene|Swp73-Like Protein Gene	The SMARCD3 Gene at 7q35-q36 encodes BAF60C, a polypeptide subunit of the transcription-promoting SWI/SNF chromatin-remodeling complex and homologue of yeast SWP73. BAF60C is similar to BAF60A and BAF60B. Chromatin remodeling of some genes appears to precede transcriptional activation. In yeast, the multisubunit SWI/SNF complex is thought responsible for chromatin remodeling. Human SWI/SNF is composed of nine to twelve BAF polypeptides. (From OMIM and NCI)
C19878	SMARCA4_Gene	SWI-SNF-Related_Gene	SMARCA4 Gene|BRG-1|BRG-1 Gene|BRG1|BRG1 Gene|BRM/SWI2-Related Gene-1|SMARCA4|SNF2-Beta|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 4 Gene	The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. (From LocusLink)
C19879	SMARCA2_Gene	SWI-SNF-Related_Gene	SMARCA2 Gene|BAF190|Human Brahma Gene|SMARCA2|SNF2L2|SNF2LA|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 2 Gene|Sth1p|hBRM|hSNF2alpha	The protein encoded by this gene is a member of the SWI/SNF family of proteins and is highly similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. (From LocusLink)
C19880	SWI-SNF-Related_Gene	Regulatory_Gene	SWI/SNF-Related Gene	SWI/SNF-Related Genes encode SWI2/SNF2 family proteins, which possess ATP-dependent chromatin remodeling activity that influences gene expression.
C19881	ERCC6_Gene	DNA_Repair_Gene	ERCC6 Gene|CKN2|CKN2 Gene|COFS|COFS Gene|CSB Gene|ERCC6|Excision-Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6 Gene|RAD26 Gene	The ERCC6 gene (SNF2/RAD54 Family) at chromosome 10q11 encodes Excision Repair Protein ERCC-6 (ERCC6), a putative DNA or RNA unwinding helicase involved in transcription-coupled excision repair. This protein specifically interacts with CSA proteins and with p44, a subunit of the RNA Polymerase II basal transcription factor TFIIH. It has DNA-dependent ATP-stimulated ATPase activity that may have a role in the displacement of stalled RNA Polymerase II from sites of DNA lesion and in recruitment of a DNA repair component. ERCC6 inhibits fragility of RNU1, RNU2, and RN5S genes. p53 interacts with ERCC6 and activation of p53 inhibits ERCC6, stalling transcription complexes and blocking local chromatin condensation. Defects in ERCC6 are the cause of Cockayne's syndrome type B (CSB). (NCI)
C19882	SMARCA3_Gene	SWI-SNF-Related_Gene	SMARCA3 Gene|HIP116|HLTF|Helicase-Like Transcription Factor Gene|SMARCA3|SNF2L3|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 3 Gene|Zbu1 Gene	Human HLTF Gene (SNF2/SWI2 family) at 3q25.1-q26.1 expresses 4.5 and 5.5 kb mRNAs that encode a 114-120 kD Helicase-Like Transcription Factor, which interacts with Box B regulatory sequences and contains seven consecutive motifs characteristic of ATPases and DNA helicases.  A shorter HLTF variant arises from an alternate translation initiation site.  Yeast SNF2/SWI2, and homologues, optimize gene-specific transcription by dissociating nucleosomes to facilitate DNA binding of regulatory proteins.  HLTF binds to viral promoters/enhancers, displaying enhancer stimulated DNA-dependent ATPase activity; HLTF may affect transcription as a DNA-binding site-specific ATPase.  HLTF contains a RING finger motif apart from an N-terminal DNA-binding domain.  (from OMIM and NCI)
C19883	SMARCA5_Gene	SWI-SNF-Related_Gene	SMARCA5 Gene|SMARCA5|SNF2H|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 5 Gene|WCRF135|hSNF2H	The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The protein encoded by this gene is a component of the chromatin remodeling and spacing factor RSF, a facilitator of the transcription of class II genes by RNA polymerase II. The encoded protein is similar in sequence to the Drosophila ISWI chromatin remodeling protein.
C19884	SMARCA1_Gene	SWI-SNF-Related_Gene	SMARCA1 Gene|SMARCA1|SNF2L|SNF2L1|SNF2LB|SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 1 Gene|SWI2	The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes.
C19885	mSin3	Mouse_Protein	mSin3|Mammalian Sin3	Important in eukaryotic gene regulation, histone acetylation and deacetylation are catalyzed by histone deacetylase complexes that include SAP30, SAP18, histone deacetylases, histone-binding proteins and other proteins. SAP18 interacts with SIN3 and enhances SIN3-mediated transcriptional repression. Gene-specific targeting of the SIN3 co-repressor complex by DNA-bound repressors is important in eukaryotic gene silencing. The SIN3 co-repressor specifically associates with some transcriptional repressors, including members of the MAD family important in development. The PAH2 domain of SIN3A interacts with the transrepression domain (SID) of MAD1. MAD-MAX complexes repress transcription through recruitment of SIN3 co-repressor. The MXI1 protein family functions as potent antagonists of MYC oncoproteins. They compete with MYC for the protein MAX and for consensus DNA binding sites and to recruit SIN3 proteins and their associated co-repressors. (NCI)
C19886	Nuclear_Receptor_Coactivator-4	Transcription_Coactivator	Nuclear Receptor Coactivator 4|ARA70|ARA70/ELE1|Androgen Receptor-Associated Protein|Androgen Receptor-Specific Coactivator|ELE1|NCOA4|NCOA4 Protein|RET Activating Protein ELE1|RFG	ARA(70), encoded by proto-oncogene NCOA4, is a ligand-dependent co-activator protein that enhances specific AR transcriptional activity.  The androgen receptor is a transcription factor of the steroid receptor superfamily.  Although several steroid-class receptors recognize the same DNA regulatory sequence, gene-specific activation may be achieved by selective accessory factors that interact with the receptors to determine specificity of target gene activation.  (from OMIM 601984 and NCI)
C19887	TIP60	Histone_Acetylase	TIP60|HIV-1 Tat Interactive Protein, 60kDa|HTATIP|TAT Interacting Protein 60|cPLA2 Interacting Protein	TIP60 interacts with the activation domain of Tat, an activator of HIV gene expression.  The yeast SAS2 transcriptional silencing protein, important for exit from the cell cycle, is closely related to TIP60.  The widely expressed cell surface amyloid-beta precursor protein is cleaved by gamma-secretase and its cytoplasmic tail forms a multimeric complex with the nuclear adaptor protein FE65 and the histone acetyltransferase TIP60.  This complex potently stimulates transcription.  (from OMIM 601409 and NCI)
C19888	Nuclear_Receptor_Coactivator-2	Transcription_Coactivator	Nuclear Receptor Coactivator 2|Glucocorticoid Receptor-Interacting Protein-1|NCOA2|NCoA-2|Nuclear Receptor Coactivator-2|TIF2|TIF2/GRIP-1|Transcriptional Intermediary Factor 2	Involved in cell growth, development, and homeostasis, 292-kb human NCOA2 Gene at 8q13.2 encodes 1464-aa 159-kD transcriptional coactivator TIF2, containing N-terminal bHLH and PAS dimerization domains. Present in a complex with NCOA3, IKKA/B, IKBKG, and CREBBP histone acetyltransferase, TIF2 interacts with HIF1A, APEX, NR3C1, and perhaps NR3C2. TIF2 coactivator interacts with steroid receptor superfamily hormone binding domains in a hormone-dependent manner. Recruitment of CBP/p300 and PCAF coactivators for myogenic MYOD and MEF2 expression depends on NCOA1, NCOA2, and NCOA3. NCOA2 is also required for expression of MYOG and CDKN1A, and for myogenic differentiation. The NCOA2 bHLH/PAS and C-terminal activation domains mediate coactivation of MEF2C through its MADS box. The NCOA2 N- and C-termini interact with MYOG. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C19889	P_CIP	Retired_Concepts	P/CIP
C19890	TRAP_Complex	Transcription_Coactivator	TRAP Complex|TRAP Mediator|TRAP Mediator Complex|TRAP/Mediator Complex|Thyroid Hormone Receptor-Associated Protein Complex	The human thyroid hormone receptor-associated protein (TRAP)-Mediator complex was originally identified as a large multimeric complex that copurifies with the thyroid hormone receptor (TR) from HeLa cells and markedly enhances TR-mediated transcription in vitro. More recent studies have implicated TRAP-Mediator as a coactivator for a broad range of nuclear hormone receptors as well as other classes of transcriptional activators. TRAP-Mediator may play an important coregulatory role in androgen receptor-mediated gene expression. (from J Biol Chem. 2002;277:42852-8)
C19891	Nuclear_Receptor_Co-Repressor-2	Transcription_Repressor_Corepressor	Nuclear Receptor Co-Repressor 2|NCOR2|SMRT|Silencing Mediator of Retinoic Acid and Thyroid Hormone Receptors|T3 Receptor-associating Factor	SMRT is a receptor-interacting factor for retinoid and thyroid-hormone receptors. The repressor function of thyroid hormone and retinoic acid receptors involves direct interaction with SMRT, possibly by stabilizing/promoting interaction with transcription factor TFIIB. Ligand causes SMRT dissociation from the receptor, triggering activation. Binding of ligand to nuclear hormone receptors induces a conformation that attracts co-activator proteins containing a NR box. NCOR1 has a similar NR box, CoRNR box, that is required for nuclear hormone receptor interaction. Sequences flanking the corner box determine nuclear hormone receptor specificity. Hormone action and differential recognition of unliganded and liganded nuclear hormone receptors by co-activators and co-repressors appears to be due to subtle differences between CoRNR and NR boxes. (from OMIM 600848 and NCI)
C19892	AML1-ETO_Chimeric_Protein	Fusion_Protein	AML-1/ETO|Acute Myeloid Leukemia-1/Eight-Twenty-One Protein	In acute myeloid leukemia, the frequent t(8;21)(q22;q22) translocation produces a chimeric AML1/ETO gene.  Association of the AML1/ETO product with the NCOR/HDAC complex blocks hematopoietic differentiation.  The interaction requires ETO coiled-coil regions and is responsible for abnormal recruitment of NCOR, transcriptional repression, and impaired differentiation of primary hematopoietic precursors. AML1/ETO transcripts are present in a fraction of stem cells, monocytes, marrow B-cells, and in colony-forming cells of erythroid, granulocyte-macrophage, and/or megakaryocyte lineages, but not in T-cells.  (from OMIM 133435 and NCI)
C19893	MAD_MXI1	Retired_Concepts	MAD/MXI1	MAD and MXI1 bZIP proteins belong to a subfamily of MAX-interacting proteins.  MAX interacts with MYC via bZIP interaction domains and MAX binding is essential for MYC activity; MYC homodimers are inactive.  MAD/MAX and MXI1/MAX heterodimers form a DNA-binding complex similar to MYC/MAX. MAD and MXI1 act as transcriptional repressors and appear to antagonize MYC by competing for MAX, and for DNA binding sites, and recruit SIN3 proteins and their associated co-repressors.  (from OMIM 600021, 600020, and NCI)
C19894	Gcn5p	Yeast_Protein	Gcn5p	Containing a bromodomain, Gcn5p is a general transcriptional activator operating in concert with other DNA-binding transcriptional activators, such as GCN4 or HAP2/3/4.  Gcn5p functions in the SAGA adaptor/HAT complex as a nucleosomal histone acetyltransferase to promote transcriptional activation.  HAT Gcn5p also functions as a heterodimer with ada2 as part of the ADA adaptor/HAT complex that consists of hfi1/ada1, ada2, ada3, spt20/ada5 and gcn5.  It has a strong preference for Lysine 14 of H3 and a lower preference for Lysines 8, 16 of H4.  (from SWISS-PROT Q03330, SGD S0003484, LocusLink 2648, and NCI)
C19895	DRD2_Gene	G_Protein-Coupled_Receptor_Gene	DRD2 Gene|D(2) Dopamine Receptor Gene|D2DR|D2DR Gene|D2R|D2R Gene|DRD2|Dopamine Receptor D2 Gene	Gene which encodes the dopamine D2 receptor (DRD2 receptor).  Different alleles are associated with increased incidence of substance abuse.
C19896	Miscellaneous_Molecular_Biology_Terms	Cancer_Science	Miscellaneous Molecular Biology Terms
C19897	National_Center_for_Complementary_and_Alternative_Medicine	Component_of_the_National_Institutes_of_Health	National Center for Complementary and Alternative Medicine|NCCAM
C19898	Dnase-I_Footprinting	DNA_Footprinting	DNase-I Footprinting	A DNA footprinting method which is commonly used for analyzing specific protein-DNA interactions. In this technique, a restriction fragment containing a specific binding site is labeled at one end and digested with DNAseI. The result is a ladder of bands, representing the various sites at which DNase I cuts. The distribution of radioactivity is visualized by autoradiography. (NCI2005)
C19899	Biochemical_Reaction	Subcellular_Process	Biochemical Reaction|Biochemical Reactions|Enzymatic Reaction|biochemical reactions	A chemical process, typically mediated by an enzyme, in which one substance (e.g., a substrate) is transformed by covalent modification into another substance(s) (e.g., a product) or in which the state of a substance is transformed. A single, or type-equivalent repetitive, enzyme-dependent chemical transformation.
C19900	Proteolytic_Processing	Biochemical_Process	Proteolytic Processing|Proteolytic Clipping	Generally irreversible, Proteolytic Processing involves removal of peptide segments from proteins, usually from the N- or C-terminus and often during polypeptide maturation, to regulate activity, location, or stability.
C19901	Dimerization	Protein-Protein_Interaction	Dimerization|Protein Dimerization	Protein dimerization is the process by which two protein molecules of similar, or dissimilar, chemical composition bind to one another by covalent or non-covalent interaction(s) to form a new functional product.
C19902	Protein_Biochemistry	Biochemistry	Protein Biochemistry|Protein/Amino Acid Biochemistry	The metabolism of proteins and amino acids.
C19903	Post-Translational_Regulation	Biochemical_Process	Post-Translational Regulation|Posttranslational Regulation	Post-Translational Regulation is controlled biochemical alteration of proteins involving generally reversible covalent modification or irreversible processing to regulate activity, location, or stability.
C19904	Enhanced_Spiral_CT	Spiral_CT	Enhanced Spiral CT|Contrast-Enhanced Spiral CT
C19905	Phased_Spiral_CT	Spiral_CT	Phased Spiral CT
C19906	Two-Phase_Spiral_CT	Phased_Spiral_CT	Two-Phase Spiral CT|Biphasic Helical CT|Dual-Phase Spiral CT
C19907	Triple-Phase_Spiral_CT	Phased_Spiral_CT	Triple-Phase Spiral CT|Triphasic Spiral CT
C19908	Quadruple_Phase_Spiral_CT	Phased_Spiral_CT	Quadruple Phase Spiral CT|Quadruple Phase Helical CT
C19909	Portal_Venous_Phase_Spiral_CT	Phased_Spiral_CT	Portal Venous Phase Spiral CT
C19910	Arterial_Phase_Spiral_CT	Phased_Spiral_CT	Arterial Phase Spiral CT
C19911	Equilibrium_Phase_Spiral_CT	Phased_Spiral_CT	Equilibrium Phase Spiral CT
C19912	Subsecond_Spiral_CT	Spiral_CT	Subsecond Spiral CT
C19913	Dynamic_Spiral_CT	Spiral_CT	Dynamic Spiral CT
C19914	Incremental_Spiral_CT	Spiral_CT	Incremental Spiral CT
C19915	Retrotransposition	DNA_Integration	Retrotransposition	Retrotransposition involves movement of a mobile eukaryotic DNA element, retrotransposon, to a new site in the genome by transcription of the element into an RNA copy that is reverse transcribed by a transposon-encoded enzyme into a DNA element that is integrated into a new site by a transposon-encoded integrase.
C19916	SAFB_Gene	Regulatory_Gene	SAFB Gene|HAP|HET Gene|HET/SAF-B Gene|HET/SAFB Gene|Hsp27-ERE-TATA-Binding Protein Gene|SAF-B|SAFB|Scaffold Attachment Factor B Gene	Human SAFB Gene at 19p13.3-p13.2 encodes HET Scaffold Attachment Factor B, a highly charged monomeric 915-amino acid protein with high S/MAR DNA-binding specificity. A 3.4 kb transcript is widely seen. The protein contains putative phosphorylation, glycosylation, and myristylation sites. Eukaryotic interphase chromatin is organized in loop domains fixed through genomic S/MAR sequences to a nuclear matrix network of protein and RNA important for chromatin compaction, gene expression, and replication. SAFA, -B, -C, and -D interact with S/MAR DNA. SAFB is also an HSP27 promoter-binding protein that decreases HSP27 transcription as an estrogen receptor corepressor. SAFB interacts with RNA polymerase II and serine-/arginine-rich RNA processing factors and may help to assemble a 'transcriptosome complex' near active genes. (from OMIM 602895 and NCI)
C19917	SRC_Gene	SRC_Family_Gene	SRC Gene|ASV|ASVSRC1|SRC|SRC1|v-SRC Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog Gene	The proto-oncogene SRC at 20q12-q13 encodes a tyrosine kinase that regulates cell communication in the control of embryonic development and cellular growth. SRC binds beta-arrestin-1 after stimulation of beta-2 adrenergic receptors. This interaction targets the complex to clathrin-coated pits and activates the MAP kinases ERK1 and ERK2. TRANCE and its receptor RANK are critical regulators of dendritic cell and osteoclast function. TRANCE activates the anti-apoptotic serine/threonine kinase AKT1 through a signaling complex involving SRC and TRAF6. SRC and TRAF6 interact with each other and with RANK upon receptor engagement. TRAF6 enhances SRC kinase activity leading to tyrosine phosphorylation of downstream targets such as CBL. SRC kinase activity is down regulated by phosphorylation of a critical C-terminal tyrosine (tyr530) and a truncating mutation in SRC at codon 531 is activating, transforming, tumorigenic, and metastasis-promoting.
C19918	SIL-SCL_Chimeric_Protein	Oncoprotein	SIL/SCL Chimeric Protein	A chimeric SIL/SCL locus, produced by interstitial deletion between SIL and the 5-prime untranslated region of SCL and disrupting the SCL regulatory region, has been observed.  SCL mRNA expression becomes regulated by the SIL promoter, leading to inappropriate SCL expression.  This type of rearrangement is frequently seen in T-cell acute lymphoblastic leukemia.  (from OMIM 181590 and NCI)
C19919	Megakaryocyte_Proliferation	Myeloproliferation	Megakaryocyte Proliferation	Megakaryocyte Proliferation involves multiplication or reproduction through cell division of megakaryocytes, a large cell in the bone marrow with a lobulated nucleus that releases mature blood platelets from its cytoplasm.
C19920	Thyroid_Hormone_Receptor_Alpha-1	Thyroid_Hormone_Receptor	Thyroid Hormone Receptor Alpha-1|C-ERBA-ALPHA-1|ERBA-Alpha Protein|ERBA-Related Protein 7|THRA|THRA Protein	A high-affinity thyroid hormone receptor expressed in many tissues, with highest levels in the central nervous system.
C19921	Dynamic_Enhanced_CT	Spiral_CT	Dynamic Enhanced CT|Dynamic Contrast Enhanced CT|Dynamic Contrast Enhanced Computed Tomography|Dynamic Contrast Material Enhanced CT|Dynamic Enhanced Computed Tomography
C19922	Tissue_Microarray	Microarray	Tissue Microarray|Tissue Arrays|Tissue Chip	A device for use in high-throughput molecular analysis/screening of clinical tissue specimens.  Tissue microarrays spatially arrange 500-1000 tumor biopsies or other tissue onto a microarray block, which is then sliced into sections for probing DNA, RNA or protein targets to provide coincident analysis of all specimens in the array.  Subsequent sections can be analyzed with additional probes.
C19923	Tissue_Expediter	Research_Personnel	Tissue Expediter|NCI Tissue Expediter	An NCI scientist whose role is to identify sources of human tissue specimens and help researchers locate the tissue and related data they need. (Bypass Budget)
C19924	Principal_Investigator	Research_Personnel	Principal Investigator|PI	The person who is responsible for a specific research project or environment.
C19925	Postdoctoral_Fellow	Research_Personnel	Postdoctoral Fellow|Postdoc|Research Associate
C19926	Venous_Phase_Spiral_CT	Phased_Spiral_CT	Venous Phase Spiral CT
C19927	Subsecond_Spiral_CT_Scanner	CT_Scanner	Subsecond Spiral CT Scanner	A subsecond spiral (or helical) CT scanner is a kind of CT scanner, where the x-ray machine rotates continuously around the body, following a spiral path to make cross-sectional pictures of the body, in ultrafast subsecond speeds.
C19928	Apoptosis_Regulator	Regulatory_Protein	Apoptosis Regulator|Regulator of Apoptosis	Encoded by Apoptosis Regulation Genes, Apoptosis Regulator proteins either promote or impede the initiation, progress, or rate of apoptosis. (NCI)
C19929	FGFR1_Gene	Fibroblast_Growth_Factor_Receptor_Family_Gene	FGFR1 Gene|FGFBR|FGFR1|FLG Gene|FLT2 Gene|FMS-Like Gene|FMS-Like Tyrosine Kinase 2 Gene|Fibroblast Growth Factor Receptor 1 Gene	Human Fibroblast Growth Factor Receptor 1 Gene (FGFR family) at 8p11.2-p11.1 encodes a 130 kD type I transmembrane protein that contains three extracellular C2-type Ig-like domains, an unusual acidic region, and an intracellular tyrosine kinase domain.  Many FGFR1 forms are produced by alternative splicing.  Ig-like domains 2 and 3 appear to bind ligand.  FGFA stimulates FGFR1 tyrosine kinase activity.  FGFR1, the human equivalent of chicken basic FGF receptor, also binds basic FGF.  An FGFR1 variant with partial kinase domain binds to FGFA without autophosphorylation or activation of PLC; it may regulate cellular responses to acidic FGF.  Defects in FGFR1 cause Pfeiffer Syndrome.  (from SWISS-PROT, OMIM, and NCI)
C19930	Fibroblast_Growth_Factor_Receptor_Family_Gene	Growth_Factor_Receptor_Gene	Fibroblast Growth Factor Receptor Family Gene	Fibroblast Growth Factor Receptor Family Genes encode Fibroblast Growth Factor Receptor Family proteins, cell surface receptors that react with (basic or acidic) fibroblast growth factors and frequently possess tyrosine kinase activity to elicit specific cellular responses to these growth factors. (NCI)
C19931	FGFR2_Gene	Fibroblast_Growth_Factor_Receptor_Family_Gene	FGFR2 Gene|BEK|BFR-1|FGFR2|Fibroblast Growth Factor Receptor 2 Gene|KGFR Gene|KSAM-1|Keratinocyte Growth Factor Receptor Gene|TK14	The 4.5 kb human Fibroblast Growth Factor Receptor 2 Gene (FGFR family) at 10q26 encodes a type I membrane protein tyrosine kinase receptor for paracrine acidic and basic FGF.  FGFR2 is closely related to mouse Bek and more distantly to chicken bFGFR.  FGF receptors have three extracellular C2-type Ig-like domains, a transmembrane segment, and a cytoplasmic tyrosine kinase domain.  Ig-like domains 2 and 3 appear to bind ligand; D2 and the D2/D3 linker region define a general binding site, alternatively spliced D3 provides specificity.  Isoforms KGFR and BEK, with different expression patterns in murine embryogenesis, vary only in a short D3 sequence that generates distinct ligand-binding features.  The dimeric FGFR2 ectodomain binds to two FGF1 ligands and a central heparin decasaccharide simultaneously.  FGFR2 defects cause Crouzon Syndrome, Jackson-Weiss Syndrome, Apert Syndrome, or Pfeiffer Syndrome.  (from SWISS-PROT, OMIM, and NCI)
C19932	Inhibition_of_Apoptosis	Cell_Death_Inhibition	Inhibition of Apoptosis|Apoptosis Inhibition	Mechanisms involved in Inhibition of Apoptosis promote biochemical processes, often enzymatic cascades, that hinder programmed cell death.
C19933	AIDS-Indirect	Funding_Category	AIDS-Indirect Research|AIDS-Indirect	Any studies (usually immunologic or virologic) that, although not directly concerned with AIDS, could reasonably be expected to contribute information useful in understanding or combatting AIDS.
C19934	HMGN1	HMGN_Family_Protein	HMGN1|Chromosomal Protein, Nonhistone, HMG14|HMG 14|HMG-14|HMG14|HMGN1 Protein|High Mobility Group Nucleosomal Binding Protein 1|High Mobility Group Protein 14|High-Mobility Group (Nonhistone Chromosomal) Protein 14|High-Mobility Group Nucleosome Binding 1|High-Mobility Group Nucleosome Binding Domain 1|Human Non-Histone Chromosomal Protein HMG-14|Nonhistone Chromosomal Protein HMG-14|Nonhistone Chromosomal Protein HMG14	HMGN1 enhances the transcriptional potential of chromatin when incorporated into nucleosomes during, but not after, chromatin assembly on replicating DNA. Two molecules of HMGN1 can bind to nucleosome cores, independently of the underlying DNA sequence, in a cooperative fashion to limit nucleosome mobility and stabilize the structure of the nucleosome core without stabilizing the higher order chromatin structure. By modifying the structure of nucleosomes, the proteins affect the local structure of the chromatin fiber leading to an increase in the rate of transcriptional elongation but not initiation. (Semin Cell Biol 1995 Aug;6(4):247-55)
C19935	MALDI-TOF_Mass_Spectrometry	Mass_Spectrometry	MALDI-TOF Mass Spectrometry|Matrix-Assisted Laser Desorption Ionization Time-of-Flight MS|Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry	In MALDI-TOF, a laser pulse is fired into a protein or peptide sample contained in a light-absorbing matrix. A small explosion vaporizes and ionizes the sample. In the presence of a high electric field, peptide ions are accelerated down an evacuated flight tube. Because large particles travel more slowly than small ones, the masses of the ionized particles are determined by measuring their arrival time at the end of the tube
C19936	Alternative_Medicine_Direct	Funding_Category	Alternative Medicine, Direct	Any medical substance or procedure not generally accepted by orthodox western medicine or an unorthodox application of an otherwise accepted substance or procedure.
C19937	Alternative_Medicine_Indirect	Funding_Category	Alternative Medicine, Indirect	Medical substance or procedure in the process of becoming accepted by orthodox western medicine.
C19938	Arctic_Research	Public_Health	Arctic Research	Health Research affecting Inuit/Eskimo populations.
C19939	ATP_Hydrolysis	Hydrolysis	ATP Hydrolysis	ATP Hydrolysis is the cleavage of a high-energy phosphate bond of adenosine triphosphate by the addition of water. The energy derived from hydrolysis of ATP is used to drive metabolic reactions including nucleic acid and protein synthesis, to move molecules against concentration gradients (active transport), and to produce mechanical motion (contraction of microfibrils and microtubules).
C19940	NK-Cell_Activation	Lymphocyte_Activation	NK Cell Activation|Natural Killer Cell Activation	NK Cell Activation involves interaction with virus-infected or transformed cells by diverse adhesion or co-stimulatory molecules and release of cytokines, chemokines, and lethal chemicals from granules.
C19941	Perinatal_Carcinogenesis	Carcinogenesis_Mechanism	Perinatal Carcinogenesis	Studies of the mechanisms by which maternal exposure to carcinogens cause cancer in in children.
C19942	Perinatal_Exposure	Environmental_and_Occupational_Exposure	Perinatal Exposure	Exposure to potentially harmful chemical, physical, or biological agents in utero or pre-conception.
C19943	Heparan_Sulfate_Biosynthesis	Biosynthesis	Heparan Sulfate Biosynthesis	Heparan Sulfate Biosynthesis consists of cellular enzymatic reactions that produce heparan sulfate, a glycosaminoglycan of repeating disaccharide units, in most cell plasma membranes. Heparan Sulfate accumulates in several mucopolysaccharidoses.
C19944	Stress_Response_Signaling	Cell_Signaling_Process	Stress Response Signaling	Stress Response Signaling is any subcellular or molecular event, process, or condition involved in receptor-ligand interaction, transduction, processing, integration, discrimination, or transmission in response to an event, process, or condition that disturbs cellular homeostasis.
C19945	RET-H4_Oncoprotein	Oncoprotein	RET/H4 Oncoprotein|RET/H4 Chimeric Oncoprotein	The PTC1 chimeric oncogene (RET/PTC1) is generated by fusion of the RET proto-oncogene receptor tyrosine kinase domain to the 5-prime terminal region of the H4 gene containing a putative leucine zipper.  H4 shows no significant homology to known genes and the protein function is unknown.  The RET receptor ligand is Glial Cell Line-Derived Neurotrophic Factor.  The putative H4 leucine zipper mediates dimerization of the PTC1 oncoprotein, essential for PTC1 transforming activity.  (from OMIM 601985 and NCI)
C19946	Limb_Development	Organogenesis	Limb Development	Interdependent positional signaling by the apical ectodermal ridge, the posterior mesenchyme zone of polarizing activity, and the non ridge ectoderm coordinate limb bud outgrowth and patterning, Limb Development, by migrated lateral plate mesoderm and somite cells. Proximal-distal differentiating mesenchymal cells condense to form the limb skeletal primordia.
C19947	Epithelial_Cell_Proliferation	Cell_Proliferation	Epithelial Cell Proliferation	Epithelial Cell Proliferation involves multiplication or reproduction through cell division of joined cells covering of internal and external surfaces of the body, including the lining of vessels and other small cavities.
C19948	Bacteriophage_Genetics	Microbial_Genetics	Bacteriophage Genetics
C19949	Angiotropin	Retired_Concepts	Angiotropin	Angiotropin is a potent angiogenesis factor isolated from the serum-free media of cultured, lectin-activated peripheral monocytes. (from Arch Surg 1989;124:693-8). Angiotropin is nonmitogenic but promotes angiogenesis by inducing migration of endothelial cells. (from Pharmacol Ther 1991;51:195-216)
C19950	Transmembrane_Transport	Transport_Process	Transmembrane Transport|Membrane Transport	Any subcellular or molecular process involved in translocation of a biological molecule across a cell membrane from one site or compartment to another. (NCI)
C19951	MYC-Associated_Factor-X	Transcription_Factor	MYC-Associated Factor X|MAX|MAX Protein	A MYC family member, MAX is a bHLH/ZIP transcription factor that forms a heterodimer with MYC and binds to a specific DNA site in the MYC gene and DDX18, a DEAD box family member.  The level of MAX is not modulated with respect to cell proliferation or differentiation, unlike most immediate early gene products.  MAX also interacts with MIX2.  (OMIM and NCI)
C19952	Immunoglobulin-Mediated_Cell_Signaling	Receptor_Signaling	Immunoglobulin-Mediated Cell Signaling	Immunoglobulin-Mediated Cell Signaling involves interaction of cell surface membrane immunoglobulin subunits of the B-cell receptor with an antigen and signal transduction by receptor-associated factors (e.g., CD79, CD22) that initiate PI, Ras, and PI3K pathways in B cell fate, maturation, tolerance, activation, proliferation, and apoptosis.
C19953	Spleen_Development	Organogenesis	Spleen Development	Human Spleen Development involves formation of the spleen, initially as a long strip of cells adjacent to the forming stomach, from mesoderm in the dorsal mesogastrium. Initially an important organ for hematopoiesis (but lost with development), migration of lymphoid precursor cells into the spleen primordium leads to a gradual conversion of the spleen to an organ of the immune system.
C19954	RET_Oncoprotein	RET_Protein	RET Oncoprotein	Human RET Oncoprotein is a product of mutated variants (Oncogene RET) of RET Gene, which encodes Tyrosine-Protein Kinase Receptor RET, a type I membrane protein receptor for Glial Cell Line-Derived with an extracellular cadherin-like domain and important in neural crest development. Some oncogenic RET point mutations cause constitutive kinase activation.  PTC1 oncogene involves fusion of RET kinase to the H4 dimerization leucine zipper.  In PTC6, RET is fused to the N-terminal part of Transcriptional Intermediary Factor-1-Alpha. In PTC7, RET is fused to a C-terminal part of TIF1-Gamma. Oncogenic RET mutations are associated with Hirschsprung's disease, Multiple Endocrine Neoplasia, pheochromocytoma, hyperparathyroidism and medullary thyroid cancer. RET Oncoprotein disrupts normal cell function.
C19955	Myeloproliferation	Cell_Proliferation	Myeloproliferation	Myeloproliferation involves both medullary and extramedullary proliferation of bone marrow constituents, such as erythroblasts, granulocytes, megakaryocytes, and fibroblasts.
C19956	Folate_Metabolism	Intermediary_Metabolism	Folate Metabolism|Folic Acid Metabolism|Folic Acid Metabolosm	Folate Metabolism involves cellular biotransforming chemical modifications of folic acid by enzymatic activity.
C19957	Quinone_Metabolism	Detoxification	Quinone Metabolism	Quinone Metabolism consists of various biochemical reactions that convert quinones, conjugated aromatic diketones derived from benzene or multiple ring hydrocarbons, to metabolic derivatives.
C19958	Androgen_Metabolism	Steroid_Metabolism	Androgen Metabolism	Androgen Metabolism consists of diverse biochemical reactions in the adrenal cortex that produce 19-carbon steroid hormones, which promote male sexual development or convert such steroids to metabolic derivatives.
C19959	Pediatric_Brain_Tumor_Consortium	NCI_Consortium_or_Network	Pediatric Brain Tumor Consortium	Network of medical centers that will evaluate promising treatments for children with brain malignancies.
C19960	Phased_Technology_Application_Award	Research_Project_Grants	Phased Technology Application Award	Similar to Phased Innovation Award, created to support the pilot application of instrumentation, techniques and analytic tools relevant to research on the molecular biology of cancer. (Bypass Budget)
C19961	in_vivo_Cellular_and_Molecular_Imaging_Centers	NCI_Consortium_or_Network	in vivo Cellular and Molecular Imaging Centers|ICMIC	To foster multidisciplinary research on cellular and molecular imaging, NCI has established In Vivo Cellular and Molecular Imaging Centers.These centers will narrow the gap between the discovery of new cancer genes and intracellular pathways, and the translation of these discoveries into clinically useful, minimally invasive imaging approaches to expanding our understanding of cancer.
C19962	Accelerated_Executive_Review	Grant_Review_Process	Accelerated Executive Review|AER|Accelerated Review	Mechanism to fund single project applications in patient oriented or basic research near the payline and for which reviewer criticisms can be addressed quickly.  (Bypass Budget)
C19963	Joining_Organizations_with_Leading_Technologies	Professional_Organization_or_Group	Joining Organizations with Leading Technologies|JOLT	NCI meetings on state-of-the-art or emerging technologies (Bypass Budget)
C19964	Association_of_Cancer_On-line_Resources	Other_Agency_or_Organization	Association of Cancer On-line Resources	Organization that hosts cancer-related listservs. (Bypass Budget)
C19965	Molecular_Epidemiology_of_Cancer	Cancer_Epidemiology	Molecular Epidemiology of Cancer	Epidemiologic research on the environmental and genetic determinants of cancer. (Bypass Budget)
C19966	Molecular_Fingerprint_of_Tumor	Miscellaneous_Molecular_Biology_Terms|Molecular_Pathology	Molecular Fingerprint of Tumor|Molecular Fingerprint|Molecular Profile|Molecular Profiles of Cancer Cells|Molecular Signature|Signatures of Cancer Cells	All cell types, depending on their functions, have unique, identifiable "signatures" - special characteristics such as which genes are active and what proteins or other cellular products are manufactured by the cell.  During transformation of a normal cell to a cancer cell, the signature changes, and that change becomes a signal of the presence of cancer.  (Bypass Budget)
C19967	Molecular_Fingerprinting_of_Tumor	Molecular_Profiling	Molecular Fingerprinting of Tumor	Determining which genes are active and inactive and the level of specific proteins that are present in a particular tumor. (Bypass Budget)
C19968	Molecular_Target_Discovery_Grants	Research_Project_Grants	Molecular Target Discovery Grants	Proposed mechanism for providing resources for "mechanisms" researchers to provide evidence that a proposed new cancer relevant molecule is a good target for drug discovery. (Bypass Budget)
C19969	AXIN1_Gene	Signaling_Pathway_Gene	AXIN1 Gene|AXIN|AXIN1|MGC52315	The AXIN1 Gene at 16p13.3 encodes Axin, an ubiquitous protein that inhibits dorsal axis formation by interfering with the WNT pathway and is involved in degradation of beta-catenin. WNT signaling causes translocation of Axin to the membrane and interaction with the intracellular domain of the WNT signal-transducing co-receptor LRP5. This destabilizes Axin and stabilizes cytoplasmic beta-catenin accumulation, which then binds to TCF/LEF1 transcription factor and up regulates target gene expression. Axin interacts with GSK3B and with beta-catenin and may facilitate phosphorylation of beta-catenin and APC by GSK3B. Axin may also bind to gamma-catenin, APC, DVL and PP2A. It is phosphorylated by GSK3B and dephosphorylated by PP2A. Axin interaction with beta-catenin is mediated by the armadillo repeats of beta-catenin. Axin contains a regulator of G protein signaling domain and a DIX domain. (from SWISS-PROT, OMIM, and NCI)
C19970	Pattern_Formation	Morphogenesis	Pattern Formation	Pattern Formation is a developmental morphogenetic process that establishes basic configurations of cellular organization necessary for further and accurate development of the spatial arrangements of embryonic tissue.
C19971	Dorsal-Ventral_Pattern_Formation	Pattern_Formation	Dorsal-Ventral Pattern Formation	Dorsal-Ventral Pattern Formation is a developmental morphogenetic process that establishes the basic configuration of cellular organization necessary for further and accurate development of the spatial arrangement of embryonic tissue along the dorsal-ventral axis.
C19972	Signatures_of_Cancer_Cells	Retired_Concepts	Signatures of Cancer Cells|Molecular Profiles of Cancer Cells	All cell types, depending on their functions, have unique, identifiable "signatures" - special characteristics such as which genes are active and what proteins or other cellular products are manufactured by the cell.  During transformation of a normal cell to a cancer cell, the signature changes, and that change becomes a signal of the presence of cancer.  (Bypass Budget)
C19973	Quick_Trials_Program	Funding	Quick Trials Program	Promises to speed the translation of ideas developed in the laboratory to early stage clinical trials by simplifying the grant application process and providing a rapid turnaround from application to funding.
C19974	Biosynthetic_Chemistry	Synthesis_Chemistry	Biosynthetic Chemistry	A branch of chemistry dealing with the biosynthesis of compounds.
C19975	NCI_Consortium_or_Network	Professional_Organization_or_Group	Consortium or Network|Centers, Networks, and Consortia|Consortium|NCI Consortium or Network|Network	Groups of scientists who link their expertise and resources in collaborative efforts to address important questions of shared interest.
C19976	Regional_Enhancement_Center	NCI-Designated_Cancer_Center	Regional Enhancement Center|Regional Enhancement Cancer Centers	Mechanism to facilitate partnerships between NCI-Designated Comprehensive Cancer Centers and research institutions to provide patients and populations with improved access to studies.
C19977	Nicotine_Inhaler	Drug_Delivery_System	Nicotine Inhaler|Nicotrol Inhaler|Smokeless Nicotine Inhaler	The nicotine inhaler, or "puffer," is a device consisting of a mouthpiece and a thin, plastic cartridge that contains a 4 mg nicotine plug and delivers nicotine in a vapor that is absorbed in the mouth.
C19978	Special_Populations_Networks	NCI_Consortium_or_Network	Special Populations Networks|SPN|Special Populations Network for Cancer Awareness Research and Training	NCI initiative to develop and maintain partnerships between scientific researchers and community leaders from a broad range of minority and underserved populations.
C19979	Structural_Biologist	Research_Personnel	Structural Biologist	A science professional who pursues structural analysis of living material at every level of organization by all methods.
C19980	NCI-Designated_Cancer_Center	NCI_Consortium_or_Network	NCI-Designated Cancer Center	Centers coordinate multidisciplinary approaches to research questions, provide access to the most advanced research technologies and take rapid advantage of new research opportunities.  (SPORES - Specialized Programs of Research Excellence are an example focused on specific disease).  Additional examples include tobacco research, molecular and in-vivo imaging, communications, populations health and interventions directed against molecular targets.
C19981	Transdisciplinary_Tobacco_Research_Center	Component_of_the_Division_of_Cancer_Control_and_Population_Sciences	Transdisciplinary Tobacco Research Center|TTRC|TTURC|Transdisciplinary Tobacco Use Research Center	Proposed network in collaboration with National Institute on Drug Abuse (NIDA) to study tobacco use initiation and prevention, treatment and treatment of tobacco related cancers.
C19982	NCI_Unconventional_Innovations_Program	Funding_Mechanisms	NCI Unconventional Innovations Program|UIP|Unconventional Innovation Access Program|Unconventional Innovations Program	A program to spur development of daring technologic improvements in cancer treatment and detection in the 21st century.  A five-year, $48 million program which seeks to stimulate development of radically new technologies in cancer care that can transform what is now impossible into the realm of the possible for detecting, diagnosing, and intervening in cancer at its earliest stages of development. The vision of the Unconventional Innovations Program is to couple detection and diagnostic technologies based on remote sensing to far less invasive treatments than those employed today which, though often effective, can be uncomfortable and painful. The ultimate goal of the program is to provide medical care for cancer patients that detects early cellular changes typical of cancer and includes treatments that target molecular alterations from occurring in an individual patient's cells. (from NIH news release 10/06/98)
C19983	Centers_of_Research_Excellence	NCI_Consortium_or_Network	Centers of Research Excellence|COBRE|Center of Biomedical Research Excellence	Multidisciplinary and translational research teams focused on a specific disease, modality, biologic process or scientific area of particular significance. They are awarded sizeable amounts of flexible funding to enable them to rapidly address emerging scientific opportunities or specific challenges.
C19984	Common_Data_Element	Data_Element	Common Data Element|CDE	Data elements that have been determined to be identical between projects or contexts.
C19985	Diagnostics_Validation_Network	Retired_Concepts	Diagnostics Validation Network	Proposed NCI supported network to provide research community with means to evaluate and validate signatures and possible diagnostic value.
C19986	Biophysical_Process	Subcellular_Process	Biophysical Process	Affecting biological factors or systems, a Biophysical Process is a subatomic, atomic, or molecular process that involves passive, physical movement; attraction or repulsion (electrostatic, van der Waals, gradient, hydrogen bonding, hydrophobic, hydrophilic, etc.); radiation interaction; or non-enzymatic formation of covalent bonds.
C19987	Cancer_Progression	Disease_Progression	Cancer Progression	The worsening of a cancer over time. This concept is most often used for incurable cancers where the stage of the cancer is an important determinant of therapy and prognosis.
C19988	Organismal_Process	Biological_Process	Organismal Process|Organism-Level Process|Physiological Process	A biologic function, activity, or process involving either specialized organ functions, individual organs, organ systems, body parts, or whole organisms. (NCI)
C19989	Sensory_Process	Neurologic_Process	Sensory Process	Processes that involve and promote the transfer or transmission of stimulatory (sensory) information from the periphery to more central organized structures and mechanisms involved in processing information. (NCI)
C19990	Cancer_Informatics_Infrastructure	Cancer_Research_Infrastructure	Cancer Informatics Infrastructure	This framework will serve as a tool to create an interface among the basic, translational, clinical, and population-based research communities that participate in the research discovery process. Employing this knowledge management system will unify these research communities and will reduce drastically the time and effort needed to create and use existing or new information, making research discoveries possible at a scientist's desk, in addition to the lab. By speeding the discovery process and translation of the best discoveries into clinical interventions, the CII will transform cancer care through more effective and efficient information exchanges among all involved in cancer research. Finally, this knowledge management system will create new synergies within and among the fields of research, resulting in a dramatic acceleration of our progress against cancer. (From Bypass Budget 2001)
C19991	Clinical_Trials_Informatics_System	Computer_System	Clinical Trials Informatics System|Clinical Trials Informatics Support System|Clinical Trials Information Management System	The Clinical Trials Information Management System is an effort to develop an integrated system for managing various aspects of a clinical trial.  The overall goal of the project is to create an integrated tool to support all aspects of a clinical trial, including Protocol development/submission, Administration, Patient Management, and Data Collections and Acquisitions. (from http://www.upci.upmc.edu/internet/benedum/clinicalTrials/)
C19992	Clinical_Data_Update_System	Clinical_Trials_Informatics_System	Clinical Data Update System|CDUS	A system to standardize and streamline data reporting and reduce administration needs.  This system achieves rapid, accurate, and secure capture of clinical trial data with minimal effort. Successfully captures the majority of trial data within hours of submission. (Bypass Budget 2001 & 2002)
C19993	SKI_Oncoprotein	Oncoprotein	SKI Oncoprotein|SK Oncogene	The c-SKI proto-oncogene encodes a transcriptional repressor that homo- and heterodimerizes with the related protein, snoN.  SMAD3 associates with nuclear SKI protein in response to TGFB1 signaling, repressing transcriptional activation by SMAD3, and rendering cells resistant to the growth-inhibitory effects of TGFB.  The effects of SKI can be overcome by increased expression of SMAD3.  (from OMIM 164780 and NCI)
C19994	Electromagnetism	Physics	Electromagnetism
C19995	Attributes_of_Chemicals	Properties_or_Attributes	Attributes of Chemicals
C19996	Biological_Effect_of_Chemicals	Attributes_of_Chemicals	Biological Effect of Chemicals
C19997	Research_Funding_Categories	Funding_Category	Research Funding Categories|Placeholder While Things Are Moved Around 01
C19998	Performance_Status_0	Zubrod_Performance_Status	Performance Status 0|Zubrod Performance Status 0	Fully active, able to carry on all pre-disease performance without restriction. (Eastern Cooperative Oncology Group)
C19999	Performance_Status_1	Zubrod_Performance_Status	Performance Status 1|Karnofsky 80-90|Zubrod Performance Status 1	Restricted in physically strenuous activity but ambulatory and able to carry out work of a light or sedentary nature, e.g., light house work, office work (Eastern Cooperative Oncology Group)
C20000	Performance_Status_5	Zubrod_Performance_Status	Performance Status 5|Karnofsky 0|Zubrod Performance Status 5	Dead. (Eastern Cooperative Oncology Group)
C20001	Postdoctoral_Individual_National_Research_Service_Award	Fellowship_Programs_F-Series|Individual_National_Research_Service_Award	Postdoctoral Individual National Research Service Award|F32 Award|NRSA Individual Postdoctoral Fellowships (F32)
C20002	Predoctoral_Individual_National_Research_Service_Award	Fellowship_Programs_F-Series|Individual_National_Research_Service_Award	Predoctoral Individual National Research Service Award|F31 Award
C20003	Fellowship_Programs	Award|Grants	Fellowship Program|Fellowship Programs	Stipends or grants-in-aid granted by foundations or institutions to individuals for study.
C20004	Extramural_Funding_Mechanisms	Funding_Mechanisms	Extramural Funding Mechanisms
C20005	Mentored_Research_Scientist_Development_Award	Research_Career_Programs_K-Series	Mentored Research Scientist Development Award|K01 Award|K01 Mechanism|K01 Program|Mentored Training Award|Research Scientist Development Award
C20006	Research_Scientist_Award	Research_Career_Programs_K-Series	Research Scientist Award|K05 Mechanism|K05 Program
C20007	Physician_Scientist_Award_Program	Research_Career_Programs_K-Series	Physician Scientist Award (Program) (PSA)|K12 Mechanism|K12 Program|Mentored Clinical Scientist Development Program
C20008	Career_Transition_Award	Research_Career_Programs_K-Series	Career Transition Award|K22 Mechanism|K22 Program	The purpose of the NCI Transition Career Development Award (K22) is to provide "protected time" for newly independent investigators to develop and receive support for their initial cancer research programs.  This award is intended to facilitate the transition of investigators from the mentored to the independent stage of their careers in cancer research.  It applies to clinicians who are pursuing basic science careers; clinicians who are pursuing careers in patient-oriented research; and to individuals pursuing careers in the prevention, control and population sciences.
C20009	Academic_Teacher_Award	Research_Career_Programs_K-Series	Academic/Teacher Award|K07 Mechanism|K07 Program
C20010	Clinical_Investigator_Award	Research_Career_Programs_K-Series	Clinical Investigator Award (CIA)|Clinical Investigator Award|K08 Mechanism|K08 Program
C20011	National_Research_Service_Awards	Award	National Research Service Awards|NRSA	National Research Service Awards (NRSA) are made to individual fellowship applicants selected for award as a result of national competition for research training in specified health-related areas.  The National Institutes of Health (NIH) awards NRSA individual postdoctoral fellowships (F32) to the most promising applicants to support full-time research training related to the mission of the NIH awarding components. Some specialized individual predoctoral fellowships (F31s and F30s) and Senior  Fellowships (F33s) are also provided under the NRSA. (NRSA Guide: Sections I and II)
C20012	Exploratory_Developmental_Grant	Research_Project_Grants	Exploratory/Developmental Grant|R21 Mechanism|R21 Program	The objective of this Exploratory/Developmental Grant (R21) mechanism is to encourage applications for one-time grants to support: 1) innovative research directions requiring preliminary testing or development; 2) exploration of the use of approaches and concepts new to a particular substantive area; 3) research and development of new technologies, techniques or methods; or 4) initial research and development of a body of data upon which significant future research may be built, i.e., the data should have a high level of impact on the field. (from http://grants.nih.gov/grants/guide/pa-files/PA-00-073.html)
C20013	Exploratory_Developmental_Grant_Phase_II	Research_Project_Grants	Exploratory/Developmental Grants Phase II|R33 Mechanism|R33 Program	The R33 award is to provide a second phase for the support for innovative exploratory and development research activities initiated under the R21 mechanism. (from http://grants.nih.gov/grants/funding/ac.pdf)
C20014	Center_Core_Grants	Research_Program_Projects_and_Centers_P-Series	Center Core Grants|P30 Mechanism|P30 Program
C20015	Education_Projects	Research_Project_Grants	Education Projects|R25 Mechanism|R25 Program
C20016	National_Center_for_Research_Resources	Component_of_the_National_Institutes_of_Health	National Center for Research Resources|NCRR
C20017	Extramural_Research_Facilities_Construction_Project	Research_Facilities_Construction_Grants	Extramural Research Facilities Construction Project|C06 Award|Research Construction, Extramural|Research Facilities (Construction)	The principal objective of this program is to facilitate and enhance the conduct of PHS-supported biomedical and behavioral research by supporting the costs of designing and constructing non-Federal basic and clinical research facilities to meet the biomedical or behavioral research, research training, or research support needs of an institution or a research area at an institution. (from NIH Guide)
C20018	Research_Facilities_Construction_Grants	Research_Construction_Programs_C-Series	Research Facilities Construction Grants|C06 Mechanism|C06 Program
C20019	Specialized_Center	Research_Program_Projects_and_Centers_P-Series	Specialized Center|P50 Mechanism|P50 Program
C20020	Funding_Mechanisms	Grants_and_Contracts_NIH	Funding Mechanisms
C20021	Funding_Opportunities	Funding	Funding Opportunities
C20022	Research_and_Development-Related_Contracts_N-Series	Funding_Mechanisms	Research and Development-Related Contracts, N-Series
C20023	Ku70_Protein	Ku_Protein	Ku70 Protein|ATP-Dependent DNA Helicase II, 70 kD Subunit|G22P1|La Protein|Lupus Autoantigen|Lupus Ku Autoantigen|Thyroid Autoantigen 70kD	KU70 protein is the 70 kD subunit of the KU autoantigen, a heterodimeric DNA repair complex that binds DNA double-strand breaks, is the DNA-binding component of the DNA-dependent protein kinase, and facilitates repair by nonhomologous end-joining.  KU70 and KU80 form a dyad-symmetrical molecule with a preformed ring that encircles duplex DNA.  KU protein is also involved in V(D)J recombination.  KU is identical to DNA helicase II, an ATP-dependent DNA unwinding enzyme.  (from OMIM 152690 and NCI)
C20024	Biophotonics	Imaging_Technology	Biophotonics	Biophotonics; the technology of using light beams and forms of energy to diagnose and monitor medical conditions. (from Medscape)
C20025	_14_3_3_Sigma_Gene	Retired_Concepts	14.3.3 Sigma Gene
C20026	Flame-Broiling	Cooking_Practices	Flame-Broiling	Cooking of meats over an open flame.  A cooking practice associated with increased risk of breast cancer.
C20027	Protein_Organized_by_Function	Protein	Protein, Organized by Function|Proteins [By Function]	Organizing term for the Proteins tree
C20028	Protein_Organized_by_Structure	Protein	Protein, Organized by Structure|Proteins [By Structure]	Organizing term for the Proteins tree
C20029	Lipoprotein	Protein_Organized_by_Structure	Lipoprotein	An important class of serum proteins in which a spherical hydrophobic core of triglycerides or cholesterol esters surrounded by an amphipathic monolayer of phospholipids, cholesterol and apolipoproteins. Classified according to density: chylomicrons, large low density particles, very low density, low density and high density species. Important in lipid transport, especially cholesterol transport in the blood stream. Abnormalities in lipoprotein metabolism have been implicated in certain heart diseases. (On-line Medical Dictionary)
C20030	Protein_Organized_by_Location	Protein	Protein, Organized by Location|Proteins [By Location]	Organizing term for the Proteins tree
C20031	Extracellular_Protein	Protein_Organized_by_Location	Extracellular Protein	Proteins secreted out of the cell to perform a function in the extracellular medium.
C20032	Protein_Organized_by_Origin	Protein	Protein, Organized by Origin|Proteins [By Origin]	Organizing term for the Proteins tree
C20033	Cytoplasmic_Protein	Protein_Organized_by_Location	Cytoplasmic Protein	Protein within the interior of the cell; excludes membrane, mitochondrial, and nuclear proteins.
C20034	Senior_Scientist_Award	Research_Scientist_Award	Senior Scientist Award|K05 Award	The Senior Scientist Award (K05) provides stability of support to outstanding scientists who have demonstrated a sustained, high level of productivity and whose expertise, research accomplishments, and contributions to the field have been and will continue to be critical to the mission of the particular NIH center or institute.  The award provides salary support for award periods of five years as a means of enhancing the individual recipient's skills and dedication to his/her area of research.
C20035	Fluorescence_Bronchoscopy	Bronchoscopy	Fluorescence Bronchoscopy	Fluorescence bronchoscopy is based on the fact that normal tissue fluoresces differently than abnormal tissue when exposed to an appropriate wavelength of light and that this difference can be detected.
C20036	Nuclear_Orphan_Receptor	Nuclear_Hormone_Receptor_Superfamily	Nuclear Orphan Receptor	Transcription factors in the nuclear receptor superfamily for which a natural ligand has not been identified.
C20037	FAK_Family_Tyrosine_Kinase	Protein_Tyrosine_Kinase	FAK Family Tyrosine Kinase	Soluble cytoplasmic non-receptor FAK (Focal Adhesion Kinase) Family Tyrosine Kinases catalyze the phosphorylation of tyrosine residues in proteins with ATP or other nucleotides as phosphate donors. FAK is found in intracellular signaling focal adhesion complexes following engagement of the extracellular matrix by integrins. The C-terminal 'focal adhesion targeting' (FAT) region is necessary and sufficient for localizing FAK to focal adhesions.
C20038	Population_Attributable_Risks	Risk_Estimate	Population Attributable Risks
C20039	Hematology_Other	Hematology	Hematology, Other	The medical specialty that pertains to the anatomy, physiology, pathology, symptomatology, and therapeutics related to the blood and blood-forming tissues.
C20040	K22_Award	Career_Transition_Award	K22 Award
C20041	Technology_Development_and_Commercialization_Branch	Component_of_the_Office_of_the_Director	Technology Development and Commercialization Branch|TDCB	Oversees and coordinates technology transfer and partnering with the federal government to develop leading-edge technologies into products that improve public health.
C20042	Percent_Free_Prostate-Specific_Antigen	PSA_Assay	Percent Free Prostate-Specific Antigen	PSA circulates in the blood in two forms: free or attached to a protein molecule.  With benign prostate conditions, there is more free PSA, while cancer produces more of the attached form.  A more accurate predictor of cancer than either a patient's age or his total PSA level. (from Cancer Information Service)
C20043	Transition_Zone_PSA_Density	PSA_Assay	Transition Zone PSA Density|Transition Zone Prostate Specific Antigen Density	The ratio of serum PSA to transition zone volume.  Takes into account the size of the prostate in determining the significance of an elevated PSA level.
C20044	Pathologic_Ab-Ig_Protein	Immunoglobulin	Pathologic Ab-Ig Protein|Pathologic Ab-Ig Proteins|Placeholder for Class While NAME Is Decided	Pathologic Ab-Ig Proteins are immunoglobulin-related (IgA, IgD, IgE, IgG, IgM antibody) glycoproteins characteristically found in patients with multiple myeloma, infectious diseases, rheumatoid arthritis and other connective tissue diseases, or systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
C20045	Immunoglobulin_Gene_Rearrangement	Gene_Rearrangement	Immunoglobulin Gene Rearrangement	By translocation through a cascade of temporally ordered steps during B-cell development, Immunoglobulin Gene Rearrangement randomly joins discrete DNA segments that encode antibody variable-V, diversity-D, joining-J, and constant-C segments to complete the coding sequence for a single heavy or light chain gene. DNA recombinases recognize a palindromic heptamer and an AT-rich nonamer separated by a 12 or 23bp spacer recombination signal sequence (RSS) neighboring the coding regions; create double-stranded DNA breaks at the exon/RSS boundaries; excise intervening DNA; and ligate the DNA ends to create a contiguous reading frame.
C20046	Red_Meat_Consumption	Dietary_Practices	Red Meat Consumption	A risk factor for colorectal, stomach, and pancreatic cancer.
C20047	Diagnostic_or_Prognostic_Factor	root_node	Diagnostic or Prognostic Factor	Top level term which includes Biological Markers, Risk Factors, and Prognostic Factors.
C20048	High_Vegetable_Diet	Dietary_Practices	High Vegetable Diet	High consumption of vegetables and related micronutrients; exerts a moderate protective effect on the risk of developing breast cancer. (from Medscape)
C20049	Other_Radiation	Electromagnetic_Radiation	Radiation, Other
C20050	Pharmacogenomics	Pharmacology	Pharmacogenomics	Pharmacogenomics defines the study of the association between genetics and drug response, as well as the interplay of genotype and drug efficacy. (from Medscape)
C20051	Surgically-Created_Resection_Cavity	Surgically_Created_Structure	Surgically-Created Resection Cavity|Intrasurgical Resection Cavity|Resection Cavity|SCRC|Surgically-Created Cystic Resection Cavity	The space that is left after the surgical removal of a body part or tumor.
C20052	Papillomavirus_Protein-E4	Viral_Oncogene_Protein	Papillomavirus Protein E4	A nonstructural protein of unknown function.  It localizes to keratin filaments and so may have a role in virus release by disturbing the integrity of the infected cell. (from Virology 1996;218:114-26)
C20053	Papillomavirus_Protein-E2	Viral_Oncogene_Protein	Papillomavirus Protein E2	A viral DNA binding protein involved in viral replication.  It is a transcriptional activator and major regulator of viral DNA replication and gene expression.  May interact with p53 in vivo. (from Oncogene 1999;18:7748-54 )
C20054	Academic_Detailing	Education	Academic Detailing	Academic Detailing is an approach to educating physicians in their offices.  Academic detailing uses very short, relatively inexpensive, focused educational mechanism that can be used with physicians in the office.  Ii involves short one-on-one conversation. (from Medscape)
C20055	Nucleic_Acid_Amplification_Tests	Molecular_Biology_Techniques	Nucleic Acid Amplification Tests|NAT|Nucleic Acid Testing	Any of various amplification and detection strategies applied to detection of virus contamination in donor blood.  Specifically designed to detect recently infected individuals during the latency period before seroconversion.
C20056	Adenovirus_Protein	Viral_Protein	Adenovirus Protein
C20057	Cancer_Intervention_and_Surveillance_Modeling_Network	NCI_Consortium_or_Network	Cancer Intervention and Surveillance Modeling Network|CISNET	Created as part of the NCI Strategic Plan to Reduce Health Disparities. A collaborative group of grantees modeling the population impact of cancer control interventions for breast, prostate, and colorectal cancer. Modeling provides an opportunity to better understand the sources of health disparities in cancer mortality, extrapolate results of randomized clinical trials to groups that carry the heaviest burden of disease and have sometimes been underrepresented in trials, and provides strategies for cancer control interventions to reduce cancer-related health disparities.
C20058	H19_Gene	Gene_with_Unknown_or_Unclassified_Function	H19 Gene|ASM|ASM1|D11S813E|H19|H19, Imprinted Maternally Expressed Untranslated mRNA Gene|MGC4485	In humans the H19 gene is expressed exclusively from the maternal chromosome.  Its product is reported to be an untranslated RNA.  The gene is a developmentally regulated gene with putative tumor suppressor activity. H19 expression in developing skeletal and smooth muscles correlates with specific differentiation events in these tissues. Its accumulation increases during skeletal muscle development with maximal accumulation in adulthood and no expression in other tissues. Expression of H19 in skeletal muscle correlates with nonproliferative, actin-positive muscle cells. Loss of H19 expression may be involved in Wilms tumorigenesis. (from OMIM and NCI) )
C20059	Light-Scattering_Spectroscopy	Spectroscopy	Light-Scattering Spectroscopy	The nuclei of precancerous lesions are distinct in that they become enlarged, crowded and hyperchromatic.  Light-scattering spectroscopy can diagnose early epithelial cancers based on the scattering of light through their enlarged nuclei. (from Medscape)
C20060	CDKN1B_Gene	Cyclin-Dependent_Kinase_Inhibitor_Gene	CDKN1B Gene|CDKN1B|CDKN4|Cyclin Dependent Kinase Inhibitor 1B Gene|Kip1|P27KIP1	The CDKN1B gene encodes cyclin dependent kinase inhibitor 1B.  CDKN1B expression is regulated by PI3K/PKB and RAS/RAL regulated AFX-like forkhead proteins.  PTEN blocks cell cycle progression in G1 through negative regulation of PI3 kinase/AKT signaling to CDKN1B, increasing CDKN1B, decreasing cyclin D1, and inhibiting AKT phosphorylation.  Involved in G1 arrest, nuclear CDKN1B inhibits cyclin/CDK complexes.  CDKN1B, a CASP-3 apoptotic target, is phosphorylated by CCNE1/CDK2, ubiquitinated by SKP2, and degraded.  Low CDKN1B expression is associated with a poor prognosis.  The human gene is located at 12p13.
C20061	Neuregulin_Receptor	Growth_Factor_Receptor	Neuregulin Receptor|Heregulin Receptor	Comprised of the erbB2, erbB3, and erbB4 proteins. These proteins form homo and heterodimers, which complicates the assignment of specificities: it is known that erbB2 homodimer do not bind heregulin, but erbB2/erbB3 heterodimers do.
C20062	Cellular_Compartment_Analysis	Cytological_Techniques	Cellular Compartment Analysis|Cell Compartment Analysis	Cell partitioning techniques used to determine the subcellular distribution of molecules of interest.
C20063	Combinatorial_Synthesis_of_Small_Molecules	Combinatorial_Synthesis	Combinatorial Synthesis of Small Molecules	Technique for making and testing many complex materials in parallel: computer guided synthesis in which all possible combinations are made. Combinatorial synthesis is not random, but systematic and repetitive, using sets of chemical "building blocks" to form a diverse set of molecular entities.  Initial synthesis is usually made on a solid substrate. The technique lays down the materials in a checkerboard arrangement, as thin squares arranged in a grid.  Scientists use combinatorial chemistry to create large populations of molecules, or libraries, that can be screened efficiently en masse. (NCI/OSP)
C20064	Conformation_Dependent_Mutation_Detection	Polymorphism_Analysis	Conformation Dependent Mutation Detection	Polymorphism, single-stranded conformational, detection. Altered migration of single-stranded DNA molecules in non-denaturing gels based upon 3-D conformation. Uses PCR and/or restriction enzymes to generate short dsDNA molecules spanning a sequence of interest. The dsDNA molecules are heat denatured, and then quickly cooled. Each ssDNA molecule will assume a secondary structure (conformation) dependent upon its unique sequence.  Base mutations will often result in altered conformations, with altered mobilities, which can be visualized following separation in non-denaturing gels. (NCI/OSP)
C20065	Microdeposition	Microtechniques	Microdeposition	Thin layer deposition.  Commonly used in integrated circuit fabrication.
C20066	Microfabrication	Microtechniques	Microfabrication	The processing techniques, such as deposition, etching, and patterning, that are utilized to produce miniaturized structures and devices with feature sizes and resolution in the micron domain.  Uses a combination of micromachining and integrated circuit fabrication technology. (from U. Louisville course description)
C20067	Modeling_of_Cellular_Pathways	Computer_Modeling	Modeling of Cellular Pathways	Any representation of the individual steps in a metabolic pathway of a cell.
C20068	Spectral_Karyotyping	Chromosome_Painting|Karyotyping	Spectral Karyotyping|Color Karyotyping|Spectral Karyotype	A novel karyotyping technique which is based on the simultaneous hybridization of 24 chromosome-specific painting probes labeled with different fluorochromes or fluorochrome combinations. The measurement of defined emission spectra by means of interferometer-based spectral imaging allows for the definitive discernment of all human chromosomes in different colors. (from Schrock et al., Hum Genet 1997:101:255-62)
C20069	Prognostic_Marker	Biomarker	Prognostic Marker|Molecular Marker of Prognosis|Prognosis Marker	Genes and proteins for which the expression or presence of can help predict the course and outcome of a disease.
C20070	WRN_Gene	Helicase_Gene	WRN Gene|RECQ3|RECQL2|RECQL3|WRN|Werner Syndrome	The WRN gene at 8p12-p11.2 is deficient in Werner syndrome, characterized by genetic instability associated with cancer predisposition. The predominantly nucleolar WRN protein contains seven helicase motifs, two of which are found in all ATP-binding proteins. WRN protein catalyzes DNA unwinding and is a 3-prime-to-5-prime exonuclease but the N-terminal exonuclease activity is separate from the helicase activity. WRN may be a suppressor of illegitimate homologous recombination and may control genomic stability. WRN binds the p50 subunit of POLD1 and may facilitate POLD-mediated DNA replication/repair. The N terminus of WRN interacts with KU70 and KU86, which stimulate WRN exonuclease activity.
C20071	Administrative_Supplement	Research_Support	Administrative Supplement	Mechanism to fund current awardees whose research is going better than expected or who are poised to test new ideas.
C20072	Immunophenotype	Phenotype	Immunophenotype|IMPHENO	Immunophenotype is the characterization of a set of cells according to the antigens expressed.
C20073	Shiga_Toxin_Beta_Subunit	Bacterial_Protein	Shiga Toxin Beta Subunit	The non-catalytic beta subunit of Shiga toxin may be useful as a fusion vector for induction of antigen-specific cytotoxic T lymphocyte responses.
C20074	Telomerase-Associated_Protein-1	Ligand_Binding_Protein	Telomerase-Associated Protein 1|TEP1|Telomerase Protein Component 1	A non-catalytic subunit of Telomerase.  It is the homolog of Tetrahymena p80 telomerase protein.  It is also a component of Vault, a large cytoplasmic ribonucleoprotein of undetermined function.  In addition to TEP1, telomerase also contains an RNA component, TERC, and an enzymatic component, TERT.
C20075	Alkyltransferase_and_Aryltransferase	Transferase	Alkyltransferase and Aryltransferase|EC 2.5	Alkyltransferases and Aryltransferases are classes of enzymes that transfer an alkyl or aryl chemical group from one compound (the donor) to another compound (the acceptor). Alkyls are radicals derived from an aliphatic hydrocarbon by removal of a hydrogen atom. Aryl are radicals derived from an aromatic compound by removal of a hydrogen atom.
C20076	RNA_Polymerase	Polymerase	RNA Polymerase	RNA polymerases comprise a group of enzymes that catalyze extension, one nucleotide at a time, of the 3 prime-end of an RNA strand along a complementary DNA template.
C20077	v-sis_PDGF_Beta_Polypeptide	Viral_Protein	v-sis Platelet Derived Growth Factor, Beta Polypeptide	v-sis Platelet Derived Growth Factor beta polypeptide is the viral homologue of PDGFB.  Viral oncogenes originate from normal cellular genes by recombination between a parent nontransforming virus and host cellular DNA; the cellular genes often code for important functions in cell growth or tissue differentiation.  PDGF is the major serum polypeptide mitogen for cells of mesenchymal origin and has two dissimilar subunits, A and B.  The B chain has homology to SIS and is alone sufficient for mitogenesis.  Most proliferating cells are programmed to undergo apoptosis unless specific survival signals are provided.  PDGF promotes proliferation and inhibits apoptosis by activating the RAS/PIK3/AKT1/IKK/NFKB1 pathway, inducing putative anti-apoptotic genes.  (from OMIM 190040 and NCI)
C20078	SF-36	Questionnaire	SF-36	A 36 question survey for measuring health status and outcomes from the patient's point of view. Designed for use in surveys of general and specific populations, health policy evaluations, and clinical practice and research.  Measures 8 health concepts: 1) Limitations in physical activities because of health problems, 2) Limitations in usual role activities because of physical health problems, 3) Bodily pain, 4) General health perceptions, 5) Vitality (energy and fatigue), 6) Limitations in social activities because of physical or emotional problems, 7) Limitations in usual role activities because of emotional problems, 8) Mental health (psychological distress and well-being). (from Medical Outcomes Trust)
C20079	SF-12	Questionnaire	SF-12	A 12 question subset of the SF-36.  Designed to be administered in a shorter time.
C20080	Angiography	Radiography	Angiography|angiography	(an-jee-AH-gra-fee) A procedure to x-ray blood vessels. The blood vessels can be seen because of an injection of a dye that shows up in the x-ray pictures.
C20081	Emerging_Technologies	Technology	Emerging Technologies	Emerging technologies refers to new techniques and devices, or older techniques being used in new ways.  These technologies need to be clinical tested to determine whether they would have a positive impact on patient outcome.  Includes all areas of cancer research including detection, diagnosis, treatment, and prevention.
C20082	Shared_Pathology_Informatics_Network	NCI_Consortium_or_Network	Shared Pathology Informatics Network	A consortium of institutions connected by a model Web-based system that both provides direct access to data related to archived specimens and protects patient confidentiality.
C20083	Office_of_Communications	Component_of_the_Office_of_the_Director	Office of Communications	The Office of Communications encompasses the former Office of Cancer Communications, The Office of Liaison Activities, and the Office of Cancer Information, Communication and Education.  Its mission is to communicate accurate information about cancer and NCI activities to a wide array of audiences, including: cancer patients, family members, health care providers, community health educators, advocates, Congress, the media, and the general public.
C20084	Special_Exceptions_Process	Funding	Special Exceptions Process|Exceptions Funding	A funding mechanism designed to ensure that new investigators share the same granting success rate as more established applicants.
C20085	Proteomics	Bioinformatics	Proteomics	Proteomics aims at quantifying the expression levels of the complete protein complement (the proteome) in a cell at any given time. While proteomics research was initially focussed on two-dimensional gel electrophoresis for protein separation and identification, proteomics now refers to any procedure that characterizes the function of large sets of proteins. It is thus often used as a synonym for functional genomics.
C20086	Cancer_Clinical_Trials_Education_Program	Education	Cancer Clinical Trials Education Program	The Cancer Clinical Trials Education Program provides training to nurses and social workers to educate patients and their families about clinical trials. (Bypass Budget 2002)
C20087	CancerNet	Educational_Materials	CancerNet	A web site (http://cancernet.nci.nih.gov/) which hosts NCI's searchable clinical trials database containing information on over 1,800 active clinical trials.  (Bypass Budget 2002)
C20088	CancerTrials	Educational_Materials	CancerTrials	A web site (http://cancertrials.nci.nih.gov/) which acts as NCI's online gateway to clinical trials resources. It integrates information about clinical trials participation (including human subjects' protection), treatment advances, and related resources for patients and physicians.  (Bypass Budget 2002)
C20089	Minority_Clinical_Oncology_Awards	Award	Minority Clinical Oncology Awards	A funding mechanism of NCI to provide underrepresented minority health professionals with the opportunity to gain expertise in research.  (Bypass Budget 2002)
C20090	Cancer_Trials_Support_Unit	Professional_Organization_or_Group	Cancer Trials Support Unit|Clinical Trials Support Unit	Streamlines and centralizes administrative, financial, and data collection tasks. The submission and development of ideas for protocols are made easier through electronic forms, templates, and databases.  (Bypass Budget 2002)
C20091	Physician_Survey_on_Cancer_Susceptibility_Testing	Questionnaire	Physician Survey on Cancer Susceptibility Testing	The objectives of this survey are to: 1) determine the utilization of genetic tests by physicians at the national level, 2) ascertain physician knowledge of available genetic tests for specific cancer susceptibility genes, 3) examine physicians' general attitudes toward testing, 4) explore possible variation in utilization and knowledge/attitudes by medical specialty, type of practice, year of training completion, board status, urbanization, and geographic region. (http://www-dccps.ims.nci.nih.gov/ARP/Physician/testing.html)
C20092	Genome_Scan	Molecular_Biology_Techniques	Genome Scan	To analyse the entire genome (total genetic complement) of an individual, organism, cell or tissue.
C20093	Health_Information_National_Trends_Survey	Survey	Health Information National Trends Survey|HINTS	The first nationally representative survey of the American public - with emphasis on underserved populations - about their access to and use of cancer-related health information. From NCI's 2002 budget
C20094	Low-Dose_Spiral_CT	Spiral_CT	Low-Dose Spiral CT
C20095	Co-Receptor_Switch	Virus-Cell_Membrane_Interaction	Co-Receptor Switch|Co-Receptor Switching	During HIV infection, the virus may evolve and become able to use alternative cell surface factors as receptors for cell attachment and entry.  This can increase the tissue range of infection or allow the virus to overcome drugs which block virus entry.
C20096	Aptamer_Technology	Molecular_Biology_Techniques	Aptamer Technology	Technologies that utilize aptamers (short rigid oligonucleotides that recognize target molecules with high affinity) for biosensors, diagnostic assays, therapeutics, etc.  For example, a specific aptamer that binds tightly to a specific protein might replace a monoclonal antibody in a diagnostic assay.
C20097	Virtual_Endoscopy	Medical_Imaging_Virtual_Reality	Virtual Endoscopy	The use of 3D CT or MRI scans to construct a simulated visualization of patient specific organs similar or equivalent to those produced by standard endoscopic procedures.  Virtual endoscopic visualization avoids the risks associated with real endoscopy.  Additionally, there are many body regions not accessible to or compatible with real endoscopy that can be explored with virtual endoscopy. (from R. Robb presentation at Visible Human Project Conference)
C20098	DNA_Image_Cytometry	Flow_Cytometry	DNA Image Cytometry|DNA ICM	A technique for quantitation of cell DNA content.
C20099	WNT7A_Gene	WNT_Family_Gene	WNT7A Gene|WNT7A|Wingless-Type MMTV Integration Site Family, Member 7A Gene	The WNT7A gene encodes a human homologue of the MMTV integration site 7A, Drosophila wingless segment polarity gene.  WNT7A guides development of the female reproductive tract and controls limb development at the dorsoventral axis.  Gene expression is restricted to placenta, kidney, testis, uterus, fetal lung, and fetal and adult brain.  WNT7A is a cysteine-rich extracellular matrix intercellular signaling glycoprotein implicated in the regulation of cell fate and patterning during embryogenesis and with a high transforming potential in mouse, involved in intracellular signaling.  The human gene is located at 3p25.
C20100	WNT_Family_Gene	Signaling_Pathway_Gene	WNT Family Gene	WNT Family Genes encode secreted structurally related signaling WNT Family Proteins, implicated in oncogenesis and in several developmental processes, including regulation of cell fate and embryonic patterning. (NCI)
C20101	Proto-Oncogene_Signaling_Factor	Retired_Concepts	Proto-Oncogene, Signaling Factor
C20102	Hypermethylation	DNA_Methylation	Hypermethylation	Hypermethylation appears to be a controlled, epigenetic, heritable, and aberrant DNA methylation reaction on gene promoter regions and CpG islands associated with loss of (e.g., tumor-suppressor) gene function in diverse cellular pathways through transcriptional silencing by the formation of transcriptionally repressive chromatin.
C20103	Receptor_Gene	Ligand_Binding_Protein_Gene	Receptor Gene	Receptor Genes encode cell surface or cytoplasmic receptor proteins that each bind to specific signaling factors (such as a hormone, antigen, or neurotransmitter) causing a conformational and functional change in the ligand-bound receptor, altering its interaction with target molecules and leading to changes in cellular physiology through modification of the activity of one or more signal transduction pathways.
C20104	Bouvet_Island	Country	Bouvet Island|074|BV|BVT	An island in the South Atlantic Ocean, south-southwest of the Cape of Good Hope (South Africa). (CIA World Factbook 2002)
C20105	French_Southern_Territories	Country	French Southern Territories|260|ATF|FS|French Southern and Antarctic Lands|TF	Islands in the southern Indian Ocean, south of Africa, about equidistant between Africa, Antarctica, and Australia. (CIA World Factbook 2002)
C20106	Heard_Island_and_McDonald_Islands	Country	Heard Island and McDonald Islands|334|HM|HMD	Islands in the Indian Ocean, about two-thirds of the way from Madagascar to Antarctica. (CIA World Factbook 2002)
C20107	Kazakhstan	Country	Kazakhstan|398|KAZ|KZ|Kazakstan	A country in Central Asia, northwest of China. (CIA World Factbook 2002)
C20108	Country_Code	Code	Country Code	A county codes are alphanumeric systems designed to identifiy countries. The ISO 3166 standard includes a two letter representation, a three letter representation, and a 3 number representation.  The last two are identical to the UN system. The US State Department system maintains a separate two letter representation code set.
C20109	Topoisomerase-III_Alpha	Topoisomerase-III	Topoisomerase III Alpha|DNA Topoisomerase III Alpha|TOP3A|TOPO III Alpha|Topo III-Alpha|Topoisomerase (DNA) III Alpha|Topoisomerase, DNA, III|Topoisomerase, DNA, III, Alpha	Expressed in multiple somatic tissues (highest in testis, heart, skeletal muscle, pancreas), human TOP3 Gene (TOPI/III Family) encodes long (1001-aa, 112-kD) and short (976-aa) alternative DNA Topoisomerase III Alpha isoforms that share no homology with DNA TOPI. TOP3A catalyzes transient ATP-independent breaking/rejoining of single DNA strands, reducing negative supercoils and controlling DNA topology during transcription. The enzyme forms a complex with BLM (aa 1-133 of BLM), which recruits TOP3A to PML nuclear bodies and regulates somatic sister chromatid recombination. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C20110	Palestinian_Territory_Occupied	Country	Palestinian Territory, Occupied|275|PS|PSE	A collective name for the West Bank and the Gaza Strip, two territories in Palestine. (from Wikipedia)
C20111	South_Georgia_and_the_South_Sandwich_Islands	Country	South Georgia and the South Sandwich Islands|239|GS|SGS|SX|South Georgia and the South Sandwich	A group of islands in the South Atlantic Ocean, east of the tip of South America. (CIA World Factbook 2002)
C20112	United_States_Minor_Outlying_Islands	Country	United States Minor Outlying Islands|581|UM|UMI	The U.S. Minor Outlying Islands consist of Baker Island, Howland Island, Jarvis Island, Johnston Atoll, Kingman Reef, Midway Island, Navassa Island, Palmyra Atoll, and Wake Island (Wake Atoll).
C20113	Western_Sahara	Country	Western Sahara|732|EH|ESH|WI	A country in Northern Africa, bordering the North Atlantic Ocean, between Mauritania and Morocco. (CIA World Factbook 2002)
C20114	Binet_Staging_System	Staging_System	Binet Staging System|Binet Classification	A staging system for Chronic Lymphocytic Leukemia.  The Binet classification integrates the number of nodal groups involved with the disease with bone marrow failure. Its major benefit derives from the recognition of a predominantly splenic form of the disease, which may have a better prognosis than in the Rai staging, and from recognition that the presence of anemia or thrombocytopenia has a similar prognosis and does not merit a separate stage.  Clinical stage A: no anemia or thrombocytopenia and fewer than three areas of lymphoid involvement (Rai stages 0, I, and II); Clinical stage B: no anemia or thrombocytopenia with three or more areas of lymphoid involvement (Rai stages I and II): Clinical stage C: anemia and/or thrombocytopenia regardless of the number of areas of lymphoid enlargement (Rai stages III and IV) (from OncoLink)
C20115	Rai_Staging_System	Staging_System	Rai Staging System	A staging system for Chronic Lymphocytic Leukemia.  Stage 0: absolute lymphocytosis (>15,000 per cubic millimeter) without adenopathy, hepatosplenomegaly, anemia, or thrombocytopenia; Stage I: absolute lymphocytosis with lymphadenopathy without hepatosplenomegaly, anemia, or thrombocytopenia; Stage II: absolute lymphocytosis with either hepatomegaly or splenomegaly, with or without lymphadenopathy; Stage III: absolute lymphocytosis and anemia (hemoglobin <11 g/dL) with or without lymphadenopathy, hepatomegaly, or splenomegaly; Stage IV: absolute lymphocytosis and thrombocytopenia (<100,000 per cubic millimeter) with or without lymphadenopathy, hepatomegaly, splenomegaly, or anemia.  (from OncoLink)
C20116	Breast_Cancer_Risk_Factor	Risk_Factor	Breast Cancer Risk Factor	Any factor such as (age, ethnicity, genetic factor, family history, over-exposure to estrogen, environmental factors) which increase a person's chance of developing breast cancer.
C20117	Diffusion_MRI	Magnetic_Resonance_Imaging|Magnetic_Resonance_Spectroscopic_Imaging	Diffusion MRI	MRI method that measure the diffusion of water in the tissue, rather than the content of water as measured in conventional MRI.
C20118	International_Prognostic_Index	Prognostic_Factor	International Prognostic Index	The International Prognostic Index (IPI) is a list of five factors that help doctors assess how a non-Hodgkins lymphoma patient might respond to a certain treatment or predict the risk of disease recurrence and survival following therapy.  The factors are: 1) patient's age, 2) stage of disease: an indication of how localized or widespread is the disease, 3) LDH levels: serum levels often correlate with the amount of tumor in the body, 4) the number of extranodal, non-lymphatic sites found, 5) the patient's overall health. (from Lymphoma Research Foundation of America glossary (www.lymphoma.org))
C20119	PSA_Velocity	PSA_Assay	PSA Velocity	A type of PSA assay which compares changes in PSA levels over time. A sharp rise in the PSA level raises the suspicion of cancer. (from Cancer Information Service)
C20120	Age-adjusted_PSA	PSA_Assay	Age-adjusted PSA	There is a natural increase in PSA level with increasing age.  Thus, the normal PSA level changes with age.  Age-adjusted PSA establishes normal values in 10-year age blocks.  (from Cancer Information Service)
C20121	Molecular_Carcinogenesis	Carcinogenesis_Mechanism	Molecular Carcinogenesis	Research that focuses on the genetics and mechanisms of cell transformation; the role of oxygen radicals in the carcinogenesis process; and identification and properties of tumor promoters and mechanisms of tumor promotion.
C20122	Experimental_Tobacco_Carcinogenesis	Carcinogenesis_Mechanism	Experimental Tobacco Carcinogenesis	Studies on the toxicology and pharmacology of smoking and tobacco-related exposures.  The research in this category is directed toward understanding the nature of the chemicals involved, and the reaction mechanisms behind, the deleterious effects of tobacco smoke and smokeless tobacco products.
C20123	CSK_Gene	Non-Receptor_Tyrosine_Kinase_Gene	CSK Gene|CSK|c-SRC Tyrosine Kinase Gene	The CSK gene is ubiquitously expressed and encodes a novel cytoplasmic tyrosine kinase that down regulates the tyrosine kinase activity of c-src oncoprotein through phosphorylation of the c-src carboxy terminus.  Since cell transformation by SRC oncoproteins is caused by mechanisms that interfere with this phosphorylation, the CSK gene might function as an antioncogene.  The SH3 domain of CSK associates with a proline-rich region of PEP, a protein-tyrosine phosphatase expressed in hemopoietic cells.  This association is highly specific; PEP may be an effector and/or regulator of CSK in T-cells and other hemopoietic cells.
C20124	Reticulon-4	Regulatory_Protein	Reticulon 4|Neurite Growth Inhibitor 220|Neurite Outgrowth Inhibitor|Neuroendocrine-Specific Protein C Like (foocen)|Nogo-A	Nogo are high molecular weight transmembrane inhibitors of neurite out-growth found in CNS myelin.  Nogo is expressed by oligodendrocytes in white matter of the CNS, but not by Schwann cells in peripheral nerves.  The C-terminal region shares homology with neuroendocrine-specific proteins and other members of the reticulon gene family.  NOGO consists of a putative large extracellular domain with seven predicted N-linked glycosylation sites, two or three transmembrane domains, and a short C-terminal region.  An extracellular domain of NOGO inhibits axonal extension but does not alter non-neuronal cell morphology.  Nogo A, B, and C are encoded as splice variants of a single gene.  (from OMIM 604475 and NCI)
C20125	Tankyrase	Polymerase	Tankyrase|PARP Homolog|TNKS|TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase|Telomeric Poly (ADP-Ribose) Polymerase|Telomeric Poly-(ADP-Ribose)-Polymerase	Tankyrase, a protein containing 24 ankyrin repeats and homology to the catalytic domain of PARP, is localized to human telomeres.  The tankyrase ankyrin domain interacts with TRF1, which regulates telomere length by inhibiting telomerase.  Tankyrase may have PARP activity and may function as acceptor for adenosine diphosphate (ADP)-ribosylation. Tankyrase may act as a positive regulator of telomere elongation by inhibiting TRF1; tankyrase-mediated ADP-ribosylation of TRF1 may open the telomeric complex, allowing access to telomerase.  Tankyrase gene was mapped to 8p23.1. (from OMIM 603303 and NCI)
C20126	Structural_Genomics	Bioinformatics	Structural Genomics	The combination of computational DNA sequence analysis with structural determinations by X-ray crystallography and NMR techniques to study protein structural families. (from RFA: GM-99-009)
C20127	CEA_Assay	Test|Test_Generic	CEA Assay|CEA assay|Carcinoembryonic Antigen Assay	A laboratory blood test to measure carcinoembryonic antigen (CEA), a protein found in many types of cells, but is associated with tumors. Used as a tumor marker.
C20128	UGT1A1_Gene	Glycosyltransferase_Gene	UGT1A1 Gene|GNT1|UDP Glycosyltransferase 1 Family, Polypeptide A1 Gene|UDP glycosyltransferase gene 1|UGT1|UGT1A|UGT1A1|UGT1A5	Expressed in liver, 100-kb human UGT1A1 Gene (UDPGT Family) contains at least 12 promoters/first exons separately spliced to common downstream exons 2-5 to yield 533-aa 60-kDa (precursor) microsomal UDP-Glucuronosyltransferase 1A1 variants with unique N-termini (and substrate specificity) preceding a common conserved 245-aa C-terminus and involved in detoxification. Catalyzing glycosyl addition from a nucleotide sugar to a hydrophobic molecule, UDPGTs represent a major glucuronidation pathway in conjugation and elimination of toxic lipophilic xeno- and endobiotics to water-soluble compounds. UGT1A1 glucuronidates its preferred substrate bilirubin and acts on simple phenols, flavones, and C18 steroids. UGT1A1 may be a major gene controlling serum bilirubin levels. (NCI)
C20129	Repairosome	Liposome	Repairosome	A liposome that contains a repair protein for use in topical lotion as therapy or prevention.
C20130	Protein_Family	Protein	Protein Family	Collection of proteins that are evolutionarily related.  This is reflected in the structural and functional similarities as well as in the extent of sequence conservation or residue identity. (from SCOP)
C20131	National_Institute_of_General_Medical_Sciences	Component_of_the_National_Institutes_of_Health	National Institute of General Medical Sciences|NIGMS	The National Institute of General Medical Sciences (NIGMS) primarily supports basic biomedical research that is not targeted to specific diseases or disorders.
C20132	Phosphoprotein_Phosphatase	Phosphatase	Phosphoprotein Phosphatase	Encoded by Protein Phosphatase Genes, Protein Phosphatase enzymes remove tyrosine-, serine-, or threonine-bound phosphate groups from many phosphoproteins, including enzymes phosphorylated by a tyrosine kinase or a serine/threonine kinase. (NCI)
C20133	Anguilla	Country	Anguilla|660|AI|AIA	An island in the Caribbean Sea, east of Puerto Rico. (CIA World Factbook 2002)
C20134	Smoking_Behavior	Personal_Behavior	Smoking Behavior|Smoking, Tobacco and Cancer-Behavior	Any of the activities associated with tobacco smoking.
C20135	IGF1R_Gene	Growth_Factor_Receptor_Gene	IGF1R Gene|IGF1R|Insulin-Like Growth Factor 1 Receptor Gene	Widely expressed human Insulin-Like Growth Factor 1 Receptor Gene (INSR family) at 15q25-q26 encodes IGF1R, a type I membrane protein that contains two fibronectin type III-like domains and has tyrosine protein kinase activity.  p53 suppresses IGF1R promoter activity.  Drosophila InR is homologous to mammalian insulin receptors.  IGF1R enhances cell survival and controls cell cycle progression.  The receptor binds IGF I with high affinity and IGF II with lower affinity.  Like INSR, cleavage of the precursor generates alpha and beta subunits.  IGF1R is a tetramer of two alpha and two beta chains linked by disulfide bonds; alpha chains form the ligand-binding domain while beta chains contain the kinase domain.  The SH2 domain of PIK3R3, a regulatory subunit of PI3 kinase, interacts with IGF1R and INSR in a kinase-dependent manner.  (from SWISS-PROT, OMIM, and NCI)
C20136	Estrogen_Metabolism	Steroid_Metabolism	Estrogen Metabolism	Estrogen Metabolism consists of diverse biochemical reactions primarily in the ovary that produce 19-carbon steroid hormones, which promote secondary female sexual development and menstrual function or convert such steroids to metabolic derivatives.
C20137	Nitrosamine_Metabolism	Carcinogen_Metabolism	Nitrosamine Metabolism	Nitrosamine Metabolism involves important cellular biochemical detoxification reactions that chemically modify the N-nitroso derivatives of secondary amines, formed by the combination of nitrates with amines. Some nitrosamines show carcinogenic activity; under certain conditions, nitrite-containing foods can form nitrosamines.
C20138	Skeletal_Development	Organogenesis	Skeletal Development	Human Skeletal Development involves growth and differentiation of axial, limb, and cranial elements of the skeletal system. Axial vertebrae and ribs derive from cartilage precursors of the paired segmented paraxial mesodermal somite sclerotomes. Interdependent positional signaling by the apical ectodermal ridge, the posterior mesenchyme zone of polarizing activity, and the non ridge ectoderm coordinate limb bud outgrowth and patterning by migrated lateral plate mesoderm and somite cells. Proximal-distal differentiating mesenchymal cells condense to form the limb skeletal primordia. The skull forms by direct ossification of, or cartilage condensation from neural crest-derived, ectomesenchyme.
C20139	Ligand_Binding	Molecular_Interaction	Ligand Binding	Ligand Binding is the tight and specific (high affinity) interaction between a small molecule (typically) and a macromolecule (usually protein) that ordinarily results in modification of its function, e.g., antigen-antibody binding, hormone- or neurotransmitter-receptor binding.
C20140	Regulation_of_Proteolysis	Post-Translational_Regulation	Regulation of Proteolysis|Proteolytic Regulation	Biochemical and cellular mechanisms involved in Regulation of Proteolysis ensure that hydrolysis of one or more peptide bonds within target proteins by proteolytic enzymes occur at the correct time and location.
C20141	Soluble_Guanylate_Cyclase	Guanylate_Cyclase	Soluble Guanylate Cyclase|GUCY|Guanylate Cyclase, Soluble|Soluble Guanylyl Cyclase|sGC	Human Soluble Guanylate Cyclases (Adenylyl Cyclase 4/Guanylyl Cyclase Family) are heterodimeric (alpha/beta) nitric oxide-activated cytoplasmic enzymes that catalyze conversion of GTP to cGMP second messenger. The main receptors for nitric oxide in the cardiovascular system and for nitrovasodilator drugs, alpha/beta interaction is required for guanylyl cyclase activity. (NCI)
C20142	Golgi_Targeting	Subcellular_Protein_Targeting	Golgi Targeting	1) To direct or use toward the Golgi apparatus as a target.  Targeting of the Golgi apparatus by specific substances to disrupt or alter its function.  2) Related to structural elements in a protein, such as a peptide sequence, that directs the localization of a protein or protein complex to the Golgi apparatus.
C20143	Nuclear_Division	Cell_Division_Process	Nuclear Division	A cell division process consisting of a complex series of events or phases (prophase, prometaphase, metaphase, anaphase, telophase) by means of which two daughter nuclei normally receive identical complements of the chromosomes and DNA content characteristic of the original somatic cells of the species.  Part of the process by which the body grows and replaces cells.  Although used interchangeably with cell division, strictly speaking the term mitosis refers to nuclear division; cytokinesis refers to division of the cytoplasm.  In some cells, as in many fungi and the fertilized eggs of many insects, nuclear division occurs within the cell unaccompanied by division of the cytoplasm and formation of daughter cells. (NCI)
C20144	DNA_Replication_Factor	Licensing_Factor	DNA Replication Factor|CDT1|DUP|Double Parked, Drosophila, Homolog of|hCdt1	DNA Replication Factor (CDT1), encoded by the CDT1 gene, is essential for DNA replication and chromatin licensing. Geminin inhibits inappropriate origin firing by targeting CDT1. CUL4 prevents aberrant reinitiation of DNA replication, at least in part, by facilitating the degradation of CDT1. (From LocusLink, OMIM and NCI)
C20145	Caspase-2	Caspase	Caspase-2|CASP-2|CASP2|Caspase 2, Apoptosis-Related Cysteine Protease|Caspase 2, Apoptosis-Related Cysteine Protease (Neural Precursor Cell Expressed, Developmentally Down-Regulated 2)|EC 3.4.22.-|ICH-1|ICH-1 Protease|ICH-1L|ICH-1L/1S|ICH1|NEDD2|NEDD2 Apoptosis Regulatory Protein|Neural Precursor Cell Expressed, Developmentally Downregulated 2	Caspase-2, encoded by the CASP2 gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspase-2 is synthesized as an inactive proenzyme which is activated by an alternative CD 95 pathway which involves the formation of a complex between oligomerized CD 95 and the accessory proteins RIP and RAIDD. After activation, caspase 2 induces apoptosis by triggering the caspase cascade. The proteolytic cleavage of this caspase is induced by a variety of apoptotic stimuli. In contrast to caspase 8, caspase 2 contains no death effector domain. (From LocusLink and NCI)
C20146	Mitotic_Recombination	Recombination	Mitotic Recombination	Mitotic Recombination, crossing over, can occur between homologous chromosomes during mitosis, but is very rare because the chromosomes do not normally pair. Chromosomes or DNA molecules are broken and the fragments are rejoined in new combinations of previously linked genes.
C20147	Transcription_Initiation	Transcription_Process	Transcription Initiation|Initiation	Transcription Initiation involves RNA polymerase (and usually other factors) binding at a specific gene promoter DNA site followed by local DNA unwinding and inauguration of the 5-prime to 3-prime biosynthesis of an RNA transcript complementary to the DNA template.
C20148	Peptide_Metabolism	Amino_Acid-Peptide-Protein_Metabolism	Peptide Metabolism	Peptide Metabolism involves cellular biotransforming chemical modifications of peptides, low molecular weight compounds containing two or more covalently bound amino acids, by enzymatic activity.
C20149	Subcellular_Protein_Targeting	Intracellular_Transport	Subcellular Protein Targeting|Intracellular Protein Transport|Protein Localization|Protein Trafficking|Protein Transport|Subcellular Targeting, Physiological	Mechanisms whereby proteins are sorted or directed to their proper location in the cell.
C20150	Induction_of_Apoptosis	Cell_Death_Induction	Induction of Apoptosis|Apoptosis Induction	Mechanisms involved in Induction of Apoptosis initiate biochemical processes, often enzymatic cascades, that promote programmed cell death.
C20151	Inflammatory_Response	Inflammation_Process	Inflammatory Response	A part of innate immunity, the Inflammatory Response occurs when injured tissues induce release of vasodilatory, opsonizing, and chemotactic mediators that attract macrophages and leukocytes to phagocytize and destroy foreign substances; dilate local blood vessels increasing local blood flow; increase capillary permeability; produce edematous swelling; and induce pain. Plasma- and cell-derived inflammatory mediators include Prostaglandins, Leukotrines, Cytokines, Lymphokines, Monokines, PAF, Histamine, Bradykinin, Complement, and Interferons.
C20152	Telomere_Maintenance	DNA_Maintenance	Telomere Maintenance	Telomeres enable cells to distinguish natural chromosome ends from damaged DNA because uncapped telomeres elicit a DNA damage response that halts cell proliferation. The protection of human chromosome ends primarily depends on the telomeric protein TRF2 and telomere capping involves the formation of a higher order structure, the telomeric loop or t-loop. Telomeres consist of a tandem array of telomeric DNA repeats bound to specialized telomeric proteins. Telomerase activity lengthens terminal regions of eukaryotic telomeric DNA by RNA-templated addition of repeated DNA sequences. Active telomerase forms a structure at the telomere that prevents chromosome ends from being sensed as DNA damage. Telomerase is regulated by sequence-specific DNA binding proteins that bind telomeric DNA repeats. Through separate domains, these proteins bind additional proteins to assemble a higher-order complex on the telomeric DNA. (from PMID 11850778 and NCI)
C20153	RNA_Interference	Post-Transcriptional_Regulation	RNA Interference|Post-Transcriptional Gene Silencing|Quelling|RNA Silencing|RNAi|Sequence-Specific Posttranscriptional Gene Silencing	Sequence-specific posttranscriptional gene silencing.  It is mediated by 21- and 22-nucleotide small interfering RNAs (siRNAs) generated by ribonuclease III cleavage from longer dsRNAs.
C20154	ACF_Complex	Drosophila_Protein_Complex	ACF complex|ACF	The Drosophila gene Acf1 encodes ATP-dependent chromatin assembly factor large subunit, a component of the chromatin assembly complex involved in chromatin assembly/disassembly.  Acf1 contains a PHD-finger and is able to modulate the internucleosomal spacing of chromatin by an ATP-dependent mechanism.  Similar sequences have been identified in Caenorhabditis elegans, Homo sapiens, Mus musculus, and Saccharomyces cerevisiae.  (from FlyBase 0027620 and NCI)
C20155	AREG_Gene	Growth_Factor_Gene	AREG Gene|AR|AREG|Amphiregulin (Schwannoma-Derived Growth Factor) Gene|Amphiregulin Gene|CRDGF|MGC13647|SDGF	Human AREG Gene (EGF family) at 4q13-q21 encodes Amphiregulin, a growth-modulating heparin-binding/heparin-inhibited bifunctional glycoprotein that inhibits growth of some cell types and stimulates proliferation of other cells.  AREG is an autocrine growth factor for keratinocytes, as well as a mitogen for astrocytes, Schwann cells, and fibroblasts.  Amphiregulin contains cysteines in disulfide linkage, an EGF-like domain, and binds to the EGF receptor, but not as well as EGF.  The protein may contain oligosaccharides and/or lipid moieties not obligatory for its biological activity.  (from SWISS-PROT, OMIM, and NCI)
C20156	Radiation-Induced_Recombination	Recombination	Radiation-Induced Recombination	Radiation-Induced Recombination involves double-stranded breaks in DNA caused by ionizing radiation, e.g., X-rays or gamma rays, that induce cellular repair functions and rejoining of the fragments in new combinations.
C20157	Non-Human_Gene	Gene	Non-Human Gene	Genes from any non-human organism.
C20158	Non-Human_Protein	Protein_Organized_by_Origin	Non-Human Protein	Proteins from organisms other than human.
C20159	Drosophila_Protein	Non-Human_Protein	Drosophila Protein	Proteins found in Drosophila.
C20160	NCI_Center_for_Cancer_Research	Component_of_the_National_Cancer_Institute	NCI Center for Cancer Research|Center for Cancer Research	Formed in Jan, 2001 by the merger of the Division of Clinical Sciences and the Division of Basic Sciences, the Center for Cancer Research is the largest component of the National Cancer Institute's Intramural Research Program.
C20161	Component_of_the_National_Cancer_Institute	Professional_Organization_or_Group	Component of the National Cancer Institute|Organizational Component of the National Cancer Institute
C20162	Component_of_the_Division_of_Cancer_Biology	Component_of_the_National_Cancer_Institute	Component of the Division of Cancer Biology
C20163	Component_of_the_Division_of_Cancer_Epidemiology_and_Genetics	Component_of_the_National_Cancer_Institute	Component of the Division of Cancer Epidemiology and Genetics
C20164	Component_of_the_Division_of_Cancer_Prevention	Component_of_the_National_Cancer_Institute	Component of the Division of Cancer Prevention
C20165	Component_of_the_Division_of_Cancer_Treatment_and_Diagnosis	Component_of_the_National_Cancer_Institute	Component of the Division of Cancer Treatment and Diagnosis
C20166	Component_of_the_Division_of_Extramural_Activities	Component_of_the_National_Cancer_Institute	Component of the Division of Extramural Activities
C20167	Component_of_the_Intramural_Research_Program	Component_of_the_National_Cancer_Institute	Component of the Intramural Research Program
C20168	Component_of_NCI_Governance	Component_of_the_National_Cancer_Institute	Component of NCI Governance
C20169	Component_of_the_Office_of_the_Director	Component_of_the_National_Cancer_Institute	Component of the Office of the Director
C20170	Component_of_the_Division_of_Cancer_Control_and_Population_Sciences	Component_of_the_National_Cancer_Institute	Component of the Division of Cancer Control and Population Sciences
C20171	Component_of_the_Center_for_Cancer_Research	Component_of_the_National_Cancer_Institute	Component of the Center for Cancer Research
C20172	Component_of_the_National_Institutes_of_Health	Professional_Organization_or_Group	Component of the National Institutes of Health
C20173	Tetracycline_Control	Expression_Technologies_for_DNA_and_RNA	Tetracycline Control	In molecular biology, refers to the transcriptional regulation of a chimeric gene by the prokaryotic repressor/operator system of the tetracycline operon, permitting the production of a specific gene product or protein in a cell culture or a transgenic animal at controlled times.  The chimeric gene contains the regulatory promoter elements of the tetracycline gene, and is transcriptionally regulated by the binding of recombinant tet repressor to these promoter elements in the absence of soluble tetracycline.
C20174	NRG1_Gene	Growth_Factor_Gene	NRG1 Gene|ARIA|GGF|GGF2|HGL|HRGA|Heregulin Gene|NDF|NEU Differentiation Factor Gene|NRG1|Neuregulin 1 Gene|SMDF	Human Heregulin Gene (NRG family) at 8p21-p12 encodes Heregulin, a glycoprotein ligand for ERBB3 and ERBB4 receptor tyrosine kinases. Alternative splicing generates a minimum of fourteen isoforms subdivided into two categories: Ig-NRG isoforms, type I (cytoplasmic tail) and II (tailless), contain an Ig-like domain; CRD-NRG isoforms (with or without tail) contain a cysteine-rich domain. All isoforms perform distinct tissue-specific functions related to growth and differentiation. Expressed in many tissues, type I predominates in endocardium. GGF2 (type II) is the major form in skeletal muscle cells. Translated products exist as a membrane protein or a proteolytic soluble factor. Glycosylation precedes cleavage. Membrane-bound forms appear inactive. Ligand binding, mediated by the EGF-like domain, recruits co-receptors ERBB1 and ERBB2. The cytoplasmic domain may interact with the LIMK1 LIM domain. (from SWISS-PROT, OMIM, and NCI)
C20175	Myelography	Diagnostic_Radiology	Myelography
C20176	Nephrotomography	Diagnostic_Radiology	Nephrotomography	Tomographic examination of the kidney.
C20177	Intravenous_Pyelography	Diagnostic_Radiology	Intravenous Pyelography|IVP|intravenous pyelography	(in-tra-VEE-nus pye-LAH-gra-fee) IVP. X-ray study of the kidneys, ureters, and bladder. The x-rays are taken after a dye is injected into a blood vessel. The dye is concentrated in the urine, which outlines the kidneys, ureters, and bladder on the x-rays.
C20178	Mammogram	Medical_Image	Mammogram|MMG|mammogram	(MAM-o-gram) An x-ray of the breast.
C20179	Toxicogenomics	Bioinformatics	Toxicogenomics	Toxicogenomics is a new scientific field that elucidates how the entire genome is involved in biological responses of organisms exposed to environmental toxicants/stressors. Toxicogenomics combines information from studies of genomic-scale mRNA profiling (by microarray analysis), cell-wide or tissue-wide protein profiling (proteomics), genetic susceptibility, and computational models to understand the roles of gene-environment interactions in disease. (from National Center for Toxicogenomics homepage)
C20180	Cell_Cycle_Stage	Cell_Division_Process	Cell Cycle Stage	Any one of the major conceptual divisions of the eukaryotic cell cycle, based on characteristic cytological and biochemical events, that occur in the order G1 (Gap 1)-S (Synthesis)-G2 (Gap 2)-M (Mitosis) and lead to cell division. (NCI)
C20181	Conceptual_Entities	root_node	Conceptual Entity	An organizational header for concepts representing mostly abstract entities.
C20182	Population_Process	Biological_Process	Population Process|Population-Level Process	A function or process affecting multiple organisms or organism groups. (NCI)
C20183	Telomerase_Reverse_Transcriptase_Protein	Protein_Complex_Subunit	Telomerase Reverse Transcriptase Protein|TERT|Telomere Reverse Transcriptase	Telomerase reverse transcriptase protein, TERT, adds telomeric DNA to the ends of eukaryotic chromosomes. Telomerase contains three subunits: the catalytic subunit TERT, an RNA component TERC, and a non-catalytic protein TEP1. Telomerase preserves chromosome integrity by maintaining telomere length; small amounts of sequence are lost because of incomplete DNA replication. Telomerase adds telomeric repeats to the 3-prime end of a G-rich primer using an RNA template. This enzyme activity is undetectable in most normal cells, but present in immortal cells and cancer tissues. Telomerase activity is an independent prognostic factor in neuroblastoma. MYC, the ubiquitous transcription factor that controls cell proliferation, directly activates transcriptional expression of TERT. (from J Clin Oncol 2000. 18:2582, OMIM 187270 and NCI)
C20184	Protein_Complex_Subunit	Protein	Protein Complex Subunit	Used for classifying a protein or peptide that does not have a perceptible function before it is assembled into a functional complex.
C20185	Gene_Transfer	Molecular_Biology_Techniques	Gene Transfer	Incorporation of new DNA into an organism's cells, usually by a vector such as a modified virus. Used in gene therapy.(From Human Genome Project Information).
C20186	NF-I	Transcription_Factor	NF-I|CCAAT Binding Transcription Factor|CCAAT-Box Binding Transcription Factor|CTF|NF-I Protein|NFI|NFIC|Nuclear Factor I|TGGCA-Binding Protein	Nuclear Factor I.  Identified as a cellular protein involved in Adenovirus DNA replication, and independently as a transcriptional activator (CTF-1, CAAT-binding transcription factor).  Ubiquitously expressed.  Four genes, NFIA, NFIB, NFIC, and NFIX encode NF-I proteins.
C20187	Cancer_Science	NCI_Administrative_Concepts	Cancer Science
C20188	Social_Concepts	Conceptual_Entities	Social Concepts
C20189	Properties_or_Attributes	root_node	Property or Attribute	The distinguishing qualities or prominent aspect of a person, object, action, process, or substance.
C20190	Chemical_Agents	Epidemiological_Factors	Chemical Agents	The consideration of chemical factors as a variable in disease incident, transmission, and control.
C20191	Cell-Matrix_Adhesion	Cell_Adhesion	Cell-Matrix Adhesion|Cell Attachment	Mechanisms whereby cells attach to the extracellular matrix.
C20192	Miscellaneous_Occupations	Occupation	Miscellaneous Occupations
C20193	Genetic_Drift	Population_Process	Genetic Drift|Genetic Differentiation|Genetic Divergence	The random change of the occurrence of a particular gene in a population, genetic drift is thought to be one cause of speciation when a group of organisms is separated from its parent population. (NCI)
C20194	Regulatory_Gene	Gene	Regulatory Gene	Regulatory Genes encode products that regulate or circumscribe the activity of diverse cellular functions.
C20195	Gene_Fusion	Gene_Mutation	Gene Fusion	Typically the result of translocation, a Gene Fusion involves the union of segments from two previously discrete genes to form a new genetic unit with altered functional characteristics.
C20196	Cancer_Center	NCI-Designated_Cancer_Center	Cancer Center|Basic Science Cancer Center|Cancer Centers	NCI-designated cancer center focused on basic research or/and cancer control research, but does not have clinical oncology research program.
C20197	Male	General_Modifier	Male|Human, Male|M	A person who belongs to the sex that normally produces sperm.  The term is used to indicate biological sex distinctions, or cultural gender role distinctions, or both.
C20198	Low_Literacy_Population	Underserved_Population	Low Literacy Population	Groups of uneducated individuals who cannot read or write.
C20199	Unspecified_Risk_Factor	Risk_Factor	Unspecified Risk Factor
C20200	Outcome	Conceptual_Entities	Outcome|Result|Results	A phenomenon that follows and is caused by some previous phenomenon.
C20201	Lifestyle_Factors_Unspecified	Epidemiological_Factors	Lifestyle Factors, Unspecified	The consideration of unspecified lifestyle factors as variables in disease incident, transmission, and control.
C20202	Wireless_Technology	Telecommunications	Wireless Technology
C20203	Laser-Induced_Fluorescence_Endoscopy	Procedure	Laser-Induced Fluorescence Endoscopy|LIFE
C20204	Preneoplastic_Change	Tumor-Associated_Process	Preneoplastic Change	Any alteration in cell state that promotes or renders a cell or cell population more vulnerable or prone to malignant conversion or transformation. (NCI)
C20205	Marker_of_Preneoplastic_Change	Disease_Marker	Marker of Preneoplastic Change
C20206	Sentinel_Lymph_Node_Mapping	Lymph_Node_Mapping	Sentinel Lymph Node Mapping|sentinel lymph node mapping	The use of dyes and radioactive substances to identify the first lymph node to which cancer is likely to spread from the primary tumor.  Cancer cells may appear first in the sentinel node before spreading to other lymph nodes and other places in the body.
C20207	Nonhomologous_DNA_End_Joining	Double_Strand_Break_Repair	Nonhomologous DNA End Joining|NHEJ|Non-Homologous End Joining	Non-homologous DNA end joining (NHEJ) can only repair double-strand breaks in which two DNA ends are rejoined by DNA ligase at regions of little or no homology to avoid degradation by DNA nucleases or noncomplementary overhanging ends. However, the disadvantage is that it can lead to loss of information from the DNA because of resection of the broken ends. NHEJ is operational throughout the cell cycle but may be more important during G1, prior to DNA replication, or in cells that are no longer cycling.
C20208	TEP1_Gene	Telomere_Maintenance_Gene	TEP1 Gene|TEP1|TLP1|TP1|Telomerase-Associated Protein 1 Gene|hTEP1 Gene	The TEP1 gene encodes a protein component of the telomerase ribonucleoprotein complex which catalyzes the addition of new telomeres on the chromosome ends as well as the vault particle which is a large cytoplasmic complex with an undetermined function. TEP1 is an RNA-binding protein that binds both the telomerase RNA and a small RNA within the vault particle. Whereas TEP1 is not essential for telomere length maintenance or telomerase activity, it is important for the stabilization and recruitment of the vault RNA to the vault particle. TEP1 RNA is expressed in variety of tissues tested and TEP1 is conserved from ciliates to humans. The TEP1 gene is located at chromosome 14q11-q12 on the long arm of chromosome 14. (NCI)
C20209	Tumor-Associated_Calcium_Signal_Transducer-1	Cell_Adhesion_Molecule	Tumor-Associated Calcium Signal Transducer 1|EGP40|Ep-CAM|Epithelial Cellular Adhesive Molecule|Epithelial Glycoprotein 40|GA733-2 Antigen|Gastrointestinal Tumor-Associated Antigen 2|KSA Glycoprotein|M4S1 Protein|Membrane Component, Chromosome 4, Surface Marker 1|TACSTD1|TROP-1	A cell adhesion molecule expressed in epithelial cells.  Overexpression in breast cancer may be correlated with histologic grade and a predictor of poor prognosis.
C20210	MLH3_Gene	DNA_Repair_Gene	MLH3 Gene|HNPCC Gene|MLH3|MutL Homolog 3 (E. coli) Gene|S240II117 Gene|hMLH3 Gene	The MLH3 gene (MUTL/HEXB family) at chromosome 14q24.3 encodes DNA Mismatch Repair Protein MLH3. MLH3 is ubiquitously expressed in various tissues and two isoforms are produced by alternative splicing. MLH3 interacts with MLH1 and shares the same interacting region on MLH1 with PMS1 and PMS2. The balance of these three competing MLH1 partners may be important in the repair of mismatches in DNA. Malfunction of the mismatch repair system results in a mutator phenotype, which is manifested as microsatellite instability (MSI). MSI is often divided into 2 forms: MSI-high (MSI-H) and MSI-low (MSI-L), based quantitatively on the observed frequency of genomic mutations. An appreciable frequency of somatic MLH3 mutations in MSI-H tumors is consistent with a possible role for this gene in the progression of colorectal cancer tumorigenesis. Germline mutations of this gene may also play a role in hereditary nonpolyposis colorectal cancer (NCI)
C20211	MSH3_Gene	DNA_Repair_Gene	MSH3 Gene|DUC1 Gene|DUG Gene|DUP Gene|MRP1 Gene|MSH3|MutS Homolog 3 (E. coli) Gene	The MSH3 gene (MutS family) at 5q11-q12 encodes DNA Mismatch Repair Protein MSH3, a mismatch repair (MMR) protein. Mismatch recognition in human cells is mediated by two heterodimers, MutS alpha (MSH2/MSH6) and MutS beta (MSH2/MSH3) with different mispair recognition properties and abilities. Both participate in repair of a dinucleotide insertion-deletion heterology but only MutS alpha restores base-base mismatch repair and shoulders primary responsibility for mismatch correction during replication. Predisposition to intestinal cancer requires loss of function of both Msh2/Msh6 and Msh2/Msh3 but Msh3 deficiency alone does not cause cancer predisposition. Mismatch repair deficiency can arise not only through mutation or transcriptional silencing of a mismatch repair gene, but also as a result of imbalance in the relative amounts of the MSH3 and MSH6 proteins because MutS alpha and MutS beta share a common component, MSH2. (NCI)
C20212	Base_Excision_Repair	Excision_Repair	Base Excision Repair|DNA Base Excision Repair	Initiation of DNA base excision repair (BER) involves a DNA glycosylase that binds the altered deoxynucleoside in an extrahelical position and catalyzes cleavage of the base-sugar bond. Subsequently, an AP endonuclease or AP lyase activity incises the abasic site, followed by short-patch gap-filling, excision of the base-free sugar-phosphate residue, and ligation.
C20213	Nucleotide_Excision_Repair	Excision_Repair	Nucleotide Excision Repair|NER|Nucleotide-Excision Repair|Transcription-Coupled Nucleotide Excision Repair|Transcription-Coupled Repair	Nucleotide Excision Repair (NER) mends DNA regions that contain chemical adducts, such as UV-induced thymine dimers or carcinogenic adducts, which distort the DNA helix and interfere with replication and transcription. NER is targeted to actively transcribed regions of the genome. During NER in eukaryotes, shape irregularities are detected by protein complexes that slide along the DNA molecule and induce cuts on each side of a lesion several nucleotides away.  Removal of the damaged 25-30 nucleotide fragment is followed by repair synthesis and ligation.
C20214	Hypoxia-Inducible_Factor-1_Alpha_Subunit	Protein_Complex_Subunit	Hypoxia-Inducible Factor 1, Alpha Subunit|HIF-1Alpha|HIF1A	Under normoxic conditions, HIF-1alpha is rapidly degraded, whereas hypoxia, CoCl(2), or desferroxamine promote protein stabilization, thus evoking its transcriptional activity.
C20215	Secondary_Cell_Culture	Cell_Culture	Secondary Cell Culture	Propagation of cell that have already been established in culture.
C20216	Adherent_Culture	Cell_Culture	Adherent Culture|Monolayer culture	A type of culture in which cells grow as a monolayer that is attached to the tissue culture flask.
C20217	Suspension_Culture	Cell_Culture	Suspension Culture	A type of culture in which cells, or aggregates of cells, multiply while suspended in liquid medium.(NCI2005)
C20218	Human_Cell_Line	Cell_Line	Human Cell Line
C20219	Monkey_Cell_Line	Cell_Line	Monkey Cell Line
C20220	Mouse_Cell_Line	Cell_Line	Mouse Cell Line
C20221	Hamster_Cell_Line	Cell_Line	Hamster Cell Line
C20222	Rat_Cell_Line	Cell_Line	Rat Cell Line
C20223	hGH_Gene	Regulatory_Gene	hGH Gene|Human Growth Hormone Gene	HGH Genes (Somatotropin/Prolactin Family) share a high degree of sequence identity and encode alternatively spliced diverse isoforms of Growth Hormone, a small secreted peptide hormone that affects gene expression, metabolism, and growth control. Due to alternative splicing, differential posttranslational modifications, optional binding to GHBP or alpha2-macroglobulin, and potential proteolytic processing, circulating GH shows great heterogeneity as a disulfide-linked or non-covalently associated monomer, dimer, trimer, tetramer, or pentamer in homopolymeric and heteropolymeric combinations. GH stimulates the liver and other tissues to secrete IGF-1. GH stimulates amino acid uptake and protein synthesis in muscle and other tissues and stimulates differentiation and proliferation of myoblasts. GH also stimulates mitosis, cell growth, and differentiation of other cell types. (NCI)
C20224	TK_Gene	Reporter_Gene	TK Gene|Thymidine Kinase Gene	The TK Gene encodes thymidine kinase, a transferase class pyrimidine salvage enzyme that catalyzes ATP-dependent phosphorylation of thymine deoxyribonucleoside. The TK gene and promoter are used widely in genetic research because of the easily selectable phenotype.
C20225	DNA_Interstrand_Cross-Link_Repair	DNA_Repair	DNA Interstrand Cross-Link Repair|Repair of DNA Interstrand Cross-Links	DNA interstrand cross-links (ICLs) are very toxic to dividing cells, because they induce mutations, chromosomal rearrangements and cell death. A number of multi-step DNA repair pathways including nucleotide excision repair, homologous recombination and post-replication/translesion repair all impinge on their repair.
C20226	HeLa	Tumor_Cell_Line	HeLa|HeLa Cells	HeLa cells were developed from cervix adenocarcinoma of a 31-year-old Black female. The cells are positive for keratin by immunoperoxidase staining. HeLa cells have been reported to contain human papilloma virus 18 (HPV-18) sequences.  P53 expression was reported to be low, and normal levels of pRB (retinoblastoma suppressor) were found. Four typical HeLa marker chromosomes have been reported.  M1 is a rearranged long arm and centromere of chromosome 1 and the long arm of chromosome 3. M2 is a combination of short arm of chromosome 3 and long arm of chromosome 5.  M3 is an isochromosome of the short arm of chromosome 5. M4 consists of the long arm of chromosome 11 and an arm of chromosome 19. HeLa Marker Chromosomes: One copy of Ml, one copy of M2, four-five copies of M3, and two copies of M4 as revealed by G-banding patterns.
C20227	HeLa_S3	Cell_Clone	HeLa S3	HeLa S3 is a clonal derivative of the parent HeLa line. S3 was cloned in 1955 by T.T. Puck, P.I. Marcus, and S.J. Cieciura. This line can be adapted to grow in suspension.
C20228	HeLa_SF	Tumor_Cell_Line	HeLa/SF	HeLa/SF is a derivative of HeLa adapted to grow in serum free medium. Over time, the serum component of the medium was replaced with TCH, a defined multipurpose serum replacement.
C20229	HL-60_MX2	Cell_Clone	HL-60/MX2	HL-60/MX2 is a mitoxantrone resistant derivative of the HL-60 cell line. HL-60/MX2 is approximately 35 fold less sensitive to mitoxantrone than the HL-60 parental cells. HL-60/MX2 cells are cross-resistant to etoposide, teniposide, bisantrene, dactinomycin, 4'-(9-acridinylamino)methane- sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin. In addition, the HL-60/MX2 cells display slight collateral sensitivity to bleomycin. Resistance to mitoxantrone is stable for up to six months.
C20230	HL-60_MX1	Tumor_Cell_Line	HL-60/MX1	HL-60/MX1 is a mitoxantrone resistant derivative of the HL-60 cell line. The cells were selected and subcloned in 1987 for resistance to 39 nM mitoxantrone, an anthracenedione antitumor agent. Subsequent exposure of the HL-60/MX1 cells to higher concentrations of mitoxantrone led to the emergence of cells capable of growth at 190 nM. HL-60/MX1 cells are cross resistant to etoposide, teniposide, bisantrene, actinomycin, 4'-(9-acridinylamino)methane-sulfon-m-anisidide, and the anthracyclines daunorubicin and doxorubicin but retain sensitivity to the Vinca alkaloids vincristine and vinblastine, melphalan, mitomycin C and cisplatin.
C20231	EG_Cell_Line	Human_Cell_Line	EG Cell Line|Embryonic Germ Cell Line	Human EG cells are derived from the primordial germ cells, which occurs in a specific part of the embryo/fetus called the gonadal ridge, and which normally develop into mature gametes (eggs and sperm). Growing pluripotent cells derived from EG cells requires the generation of embryoid bodies, which consist of an unpredictable mix of partially differentially cell types.
C20232	ES_Cell_Line	Human_Cell_Line	ES Cell Line|Embryonic Stem Cell Line	Stable cell lines derived from embryonic stem cells.  They can be propagated indefinitely in the primitive undifferentiated state while remaining pluripotent.
C20233	BG01	BresaGen_ES_Cell_Line	BG01|hESBGN.01	Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20234	BG02	BresaGen_ES_Cell_Line	BG02|hESBGN.02	Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20235	BG03	BresaGen_ES_Cell_Line	BG03|hESBGN.03	Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20236	BG04	BresaGen_ES_Cell_Line	BG04|hESBGN.04	Provider: BresaGen, Inc., Athens, GA. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA 1-60, TRA 1-81, Oct-4, and alkaline phosphatase; Cells are negative for the cell marker SSEA1. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20237	CY12	CyThera_ES_Cell_Line	CY12|hES-1-2	Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20238	CY30	CyThera_ES_Cell_Line	CY30|hES-3-0	Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20239	CY40	CyThera_ES_Cell_Line	CY40|hES-4-0	Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20240	CY51	CyThera_ES_Cell_Line	CY51|hES-5-1	Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20241	CY81	CyThera_ES_Cell_Line	CY81|hES-8-1	Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20242	CY82	CyThera_ES_Cell_Line	CY82|hES-8-2	Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20243	CY91	CyThera_ES_Cell_Line	CY91|hES-9-1	Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20244	CY92	CyThera_ES_Cell_Line	CY92|hES-9-2	Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20245	CY10	CyThera_ES_Cell_Line	CY10|hES-10	Provider: CyThera, Inc., San Diego, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20246	CyThera_ES_Cell_Line	ES_Cell_Line	CyThera ES Cell Line
C20247	BresaGen_ES_Cell_Line	ES_Cell_Line	BresaGen ES Cell Line
C20248	ES_ES_Cell_Line	ES_Cell_Line	ES ES Cell Line
C20249	ES01	ES_ES_Cell_Line	ES01|HES-1	Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extraembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20250	ES02	ES_ES_Cell_Line	ES02|HES-2	Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extraembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20251	ES03	ES_ES_Cell_Line	ES03|HES-3	Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extraembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20252	ES04	ES_ES_Cell_Line	ES04|HES-4	Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, SSEA-4, TRA-1-60, GCTM-2, and alkaline phosphatase activity; Cells are negative for cell marker SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro into extraembryonic and somatic cell lineages; Neural progenitor cells may be isolated from differentiating ES cell cultures and induced to form mature neurons; Available for distribution. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20253	ES05	ES_ES_Cell_Line	ES05|HES-5	Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Undergoing characterization. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20254	ES06	ES_ES_Cell_Line	ES06|HES-6	Provider: ES Cell International Pte Ltd., Melbourne, Australia. Information from provider and not independently verified by NIH: Undergoing characterization. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20255	Geron_ES_Cell_Line	ES_Cell_Line	Geron ES Cell Line
C20256	GE01	Geron_ES_Cell_Line	GE01|Geron H1|H1	Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20257	GE07	Geron_ES_Cell_Line	GE07|Geron H7|H7	Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20258	GE09	Geron_ES_Cell_Line	GE09|Geron H9|H9	Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20259	GE13	Geron_ES_Cell_Line	GE13|Geron H13|H13	Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20260	GE14	Geron_ES_Cell_Line	GE14|Geron H14|H14	Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20261	GE91	Geron_ES_Cell_Line	GE91|Geron H9.1|H9.1	Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20262	GE92	Geron_ES_Cell_Line	GE92|Geron H9.2|H9.2	Provider: Geron Corporation, Menlo Park, CA. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20263	Goteborg_ES_Cell_Line	ES_Cell_Line	Goteborg ES Cell Line
C20264	SA01	Goteborg_ES_Cell_Line	SA01|Sahlgrenska 1	Provider: Goteborg University, Goteborg, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20265	SA02	Goteborg_ES_Cell_Line	SA02|Sahlgrenska 2	Provider: Goteborg University, Goteborg, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20266	SA03	Goteborg_ES_Cell_Line	SA03|Sahlgrenska 3	Provider: Goteborg University, Goteborg, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20267	Karolinska_ES_Cell_Line	ES_Cell_Line	Karolinska ES Cell Line
C20268	KA08	Karolinska_ES_Cell_Line	KA08|hICM8	Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20269	KA09	Karolinska_ES_Cell_Line	KA09|hICM9	Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20270	KA40	Karolinska_ES_Cell_Line	KA40|hICM40	Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20271	KA41	Karolinska_ES_Cell_Line	KA41|hICM41	Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20272	KA42	Karolinska_ES_Cell_Line	KA42|hICM42	Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20273	KA43	Karolinska_ES_Cell_Line	KA43|hICM43	Provider: Karolinska Institute, Stockholm, Sweden. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20274	Maria_ES_Cell_Line	ES_Cell_Line	Maria ES Cell Line
C20275	MB01	Maria_ES_Cell_Line	MB01	Provider: Maria Biotech Co. Ltd. - Maria Infertility Hospital Medical Institute, Seoul, Korea. Information from provider and not independently verified by NIH: Cells are positive for cell markers Oct-4, alkaline phosphatase activity and telomerase activity; Differentiate in vitro into mature neuron, glia cells, muscle cells and beating cardiomyocytes; AFP was also detected in this cells. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20276	MB02	Maria_ES_Cell_Line	MB02	Provider: Maria Biotech Co. Ltd. - Maria Infertility Hospital Medical Institute, Seoul, Korea. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, Oct-4, alkaline phosphatase activity and telomerase activity; Cells are negative for the cell marker SSEA-1; Cell has normal karyotype (46 XX); Differentiation in vitro into neuron; Cells were cultured in feeder-free culture condition using Matrigel coated plate. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20277	MB03	Maria_ES_Cell_Line	MB03	Provider: Maria Biotech Co. Ltd. - Maria Infertility Hospital Medical Institute, Seoul, Korea. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, Oct-4, alkaline phosphatase activity and telomerase activity; Cells are negative for the cell marker SSEA-1; Cell has normal karyotype (46 XX); Differentiation in vitro into neuron; Cells were cultured in feeder-free culture condition using Matrigel coated plate. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20278	MizMedi_ES_Cell_Line	ES_Cell_Line	MizMedi ES Cell Line
C20279	MI01	MizMedi_ES_Cell_Line	MI01|Miz-hES1	Provider: MizMedi Hospital - Seoul National University, Seoul, Korea. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20280	Tara_ES_Cell_Line	ES_Cell_Line	Tara ES Cell Line
C20281	NC01	Tara_ES_Cell_Line	NC01|FCNCBS1	Provider: National Centre for Biological Sciences/ Tata Institute of Fundamental Research, Bangalore, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20282	NC02	Tara_ES_Cell_Line	NC02|FCNCBS2	Provider: National Centre for Biological Sciences/ Tata Institute of Fundamental Research, Bangalore, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20283	NC03	Tara_ES_Cell_Line	NC03|FCNCBS3	Provider: National Centre for Biological Sciences/ Tata Institute of Fundamental Research, Bangalore, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20284	Pochon_ES_Cell_Line	ES_Cell_Line	Pochon ES Cell Line
C20285	CH01	Pochon_ES_Cell_Line	CH01|CHA-hES-1	Provider: Pochon CHA University, Seoul, Korea. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20286	CH02	Pochon_ES_Cell_Line	CH02|CHA-hES-2	Provider: Pochon CHA University, Seoul, Korea. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20287	Reliance_ES_Cell_Line	ES_Cell_Line	Reliance ES Cell Line
C20288	RL05	Reliance_ES_Cell_Line	RL05|RLS ES 05	Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20289	RL07	Reliance_ES_Cell_Line	RL07|RLS ES 07	Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20290	RL10	Reliance_ES_Cell_Line	RL10|RLS ES 10	Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20291	RL13	Reliance_ES_Cell_Line	RL13|RLS ES 13	Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20292	RL15	Reliance_ES_Cell_Line	RL15|RLS ES 15	Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20293	RL20	Reliance_ES_Cell_Line	RL20|RLS ES 20	Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20294	RL21	Reliance_ES_Cell_Line	RL21|RLS ES 21	Provider: Reliance Life Sciences, Mumbai, India. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20295	Technion_ES_Cell_Line	ES_Cell_Line	Technion ES Cell Line
C20296	TE03	Technion_ES_Cell_Line	TE03|I 3	Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20297	TE32	Technion_ES_Cell_Line	TE32|I 3.2	Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20298	TE33	Technion_ES_Cell_Line	TE33|I 3.3	Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20299	TE04	Technion_ES_Cell_Line	TE04|I 4	Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20300	TE06	Technion_ES_Cell_Line	TE06|I 6	Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20301	TE62	Technion_ES_Cell_Line	TE62|I 6.2	Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20302	TE07	Technion_ES_Cell_Line	TE07|J 3	Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20303	TE72	Technion_ES_Cell_Line	TE72|J 3.2	Provider: Technion University, Haifa, Israel. No information from provider. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20304	UCSF_ES_Cell_Line	ES_Cell_Line	UCSF ES Cell Line
C20305	UC01	UCSF_ES_Cell_Line	UC01|HSF-1	Provider: University of California, San Francisco, CA. Information from provider and not independently verified by NIH: Cells differentiate in vitro into all three germ layers; Cells are positive for cell marker Oct-4, SSEA-3, SSEA-4, and alkaline phosphatase; Cells are negative for SSEA-1; Cells will be available only for collaboration once the MTA is completed. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20306	UC06	UCSF_ES_Cell_Line	UC06|HSF-6	Provider: University of California, San Francisco, CA. Information from provider and not independently verified by NIH: Cells have normal morphology and a normal female karyotype. Cells differentiate in vitro into all three germ layers; Cells are positive for cell marker Oct-4, SSEA-3, SSEA-4, and alkaline phosphatase; Cells are negative for SSEA-1; Cells will be available only for collaboration once the MTA is completed. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20307	Wisconsin_ES_Cell_Line	ES_Cell_Line	Wisconsin ES Cell Line
C20308	WA01	Wisconsin_ES_Cell_Line	WA01|H1|Wisconsin H1	Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Documented quality control includes karyotype analysis, DNA fingerprinting, mycoplasma testing, and human virus testing. Frozen vials of cells in passage 22 are available immediately. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20309	WA07	Wisconsin_ES_Cell_Line	WA07|H7|Wisconsin H7	Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro. Cells not yet ready for distribution. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20310	WA09	Wisconsin_ES_Cell_Line	WA09|H9|Wisconsin H9	Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Cells not yet ready for distribution. Publications: Thomson et al., Science 282, 1145, 1998; Amit et al., Developmental Biology 227, 271, 2000. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20311	WA13	Wisconsin_ES_Cell_Line	WA13|H13|Wisconsin H13	Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1; Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Cells not yet ready for distribution. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20312	WA14	Wisconsin_ES_Cell_Line	WA14|H14|Wisconsin H14	Provider: Wisconsin Alumni Research Foundation (WARF), Madison, WI. Information from provider and not independently verified by NIH: Cells are positive for cell markers SSEA-3, SSEA-4, TRA-1-60, TRA-1-81, and alkaline phosphatase; Cells are negative for SSEA-1. Give rise to teratomas containing derivatives of three germ layers in SCID mice; Differentiate in vitro; Cells not yet ready for distribution. Publication: Thomson et al., Science 282, 1145, 1998. This cell line meets the criteria for the use of human embryonic stem cells by federally funded researchers.
C20313	Tumor_Cell_Line	Human_Cell_Line	Tumor Cell Line
C20314	Protein_Truncation	Protein_Sequence_Alteration	Protein Truncation	Protein truncation can occur as a result of those mutations that lead to the termination of mRNA translation, including (1) Nonsense mutation where single nucleotide substitution produces a stop codon (TGA, TAA or TAG) and mRNA translation stops at the point of mutation; (2) Frameshift mutation where one or more nucleotides are either inserted or deleted. If the number of bases is not divisible by 3, a change in the reading frame alters the remainder of the translation of the mRNA, and frequently a stop codon is introduced prematurely; (3) Splice site mutation where one or more nucleotides are inserted or deleted, leading to the presence of a stop codon at a splice site.
C20315	Trace_Metal_Storage_Protein	Ligand_Binding_Protein	Trace Metal Storage Protein
C20316	WRN_Protein	RecQ_Helicase_Family_Protein	WRN Protein|WRN|Werner Syndrome Protein	The WS gene encodes WRN, a 1,432-amino acid polypeptide. WRN is a member of the RecQ family of DNA helicases that unwind duplex DNA. It can also digest DNA exonucleolytically with 3'-5' polarity. WRN may facilitate pol d-mediated DNA replication and/or DNA repair and disruption of WRN-DNA polymerase delta interaction in WS cells may contribute to the S-phase defects and/or the unusual sensitivity to a limited number of DNA damaging agents. (Proc Natl Acad Sci U S A 2000 Apr 25;97(9):4603-8)
C20317	Consumer_Advocates_in_Research_and_Related_Activities	NCI_Advisory_Boards_and_Groups	Consumer Advocates in Research and Related Activities|CARRA	A program to increase cancer advocate involvement in NCI's activities.  It convenes a large network of dedicated advocates to give insight and feedback from the consumer's perspective to developing programs. (NCI press release)
C20318	RecQL4	RecQ_Helicase_Family_Protein	RecQL4|ATP-Dependent DNA Helicase Q4|RECQ4|RTS|RecQ Protein Like 4	Mutations of the RecQL4 gene have been identified in a limited number of patients with Rothmund-Thomson syndrome (RTS), a rare autosomal recessive genetic disorder that shows chromosomal instability, premature aging, and a high risk of mesenchymal tumors. The 13.3 kD RecQL4 protein belongs to the RecQ subfamily of helicases and contains an helicase domain with a potential ATP binding site, and the DEAH box. The RecQ4 gene is predominantly expressed in thymus and testis and at low levels in other organs such as heart, brain, placenta, pancreas, small intestine, and colon, indicating that the expression of RecQ4 gene is somewhat tissue-specific. The expression of RecQ4 gene is partially upregulated in the G1/S phase of cell cycle. RecQL4 functionally suppresses promiscuous genetic recombination and ensures accurate chromosome segregation. (Beghini A. RECQL4. Atlas Genet Cytogenet Oncol Haematol. October 2001.
C20319	Licensing_Factor	Regulatory_Protein	Licensing Factor	S-phase onset is controlled, so that it occurs only once every cell cycle. DNA is licensed for replication after mitosis in G(1), and passage through S-phase removes the license to replicate. Licensing factors are required for licensing and central to ensuring that replication occurs once per cell cycle. (from J Biol Chem 2001 Nov 30;276(48):44905-11)
C20320	Replication_Initiation_Point_Mapping	Gene_Mapping	Replication Initiation Point Mapping|RIP Mapping	Replication initiation point (RIP) mapping detects start sites for DNA synthesis at the nucleotide level and thus monitors replication initiation events at the origin very precisely. Beyond detecting the precise positions of start sites, the application of RIP mapping in yeast and human cells has revealed a single, defined start point at which replication initiates. (J Cell Sci 2001 Feb;114(Pt 4):643-51)
C20321	hCdt1	Retired_Concepts	hCdt1
C20322	HMGA1a	HMGA_Family_Protein	HMGA1a|HMG I|HMG-I|HMG-I/Y|HMGA1|HMGI|a-protein	HMGA1a is one of three protein products of the same gene, HMGA1, generated by alternative splicing. The HMGA1a protein contains three basic domains, named AT-hooks and an acidic C-terminal region. AT-hooks are responsible for binding to AT-rich sequences inside the minor groove of DNA. Phosphorylation of HMGA1a by both PKC and cdc-2 kinases strongly reduces its DNA binding affinity and is critical in cell cycle progression. HMGA1a activates the interferon-beta gene (IFN-beta) by functioning as the essential architectural component for the assembly and stability of the IFN-beta enhanceosome. (PMID11576996)
C20323	HMGA1b	HMGA_Family_Protein	HMGA1b|HMG Y|HMG-Y|HMGA1|HMGY	HMGA1b, encoded by the HMGA1 gene, preferentially binds to the minor groove of A+T-rich regions in double-stranded DNA. It is involved in transcriptional regulation of the BRCA1 gene. HMGA1b overexpression accounts for BRCA1 downregulation in sporadic breast carcinomas. (From PubMed 12640109 and NCI)
C20324	HMGA2	HMGA_Family_Protein	High Mobility Group AT-Hook 2|BABL|HMGA2|HMGA2 Protein|HMGI-C|HMGIC|High Mobility Group Protein HMGIC Breakpoint Associated with Benign Lipoma|High Mobility Group Protein Isoform I-C|High-Mobility Group (Nonhistone Chromosomal) Protein Isoform I-C|High-Mobility Group Protein HMGI-C|LIPO	HMGA2 is a nuclear phosphoprotein that contains three short DNA-binding domains (AT-hooks) and a highly acidic C-terminus. The expression of the gene is cell-cycle regulated. It is likely that the HMGA2 protein acts as an architectural transcription factor, regulating the expression of one or more genes that control embryonic cell growth. Since HMGA2 binds to the minor groove of AT-rich DNA this interaction could be a target for minor groove chemotherapeutic agents in the treatment of sarcomas expressing the rearranged gene. (Int J Biochem Cell Biol 1998 Jul;30(7):761-6)
C20325	HMGA_Family_Protein	Canonical_HMG_Protein|Transcription_Factor	HMGA Family Protein|AT-Hook Protein|HMG-I(Y) Protein|HMG-I/Y Protein|HMG-I/Y/C|HMGI(Y) Protein	Members of this family of high mobility group (HMG) proteins participate in a wide variety of nuclear processes ranging from chromosome and chromatin mechanics to acting as architectural transcription factors that regulate the expression of numerous genes. As a consequence, they function in the cell as highly connected nodes of protein-DNA and protein-protein interactions that influence a diverse array of normal biological processes including growth, proliferation, differentiation and death. Each protein contains three copies of the AT-hook, that preferentially binds to the minor groove of stretches of AT-rich sequence. HMGA genes are bona fide proto-oncogenes that promote tumor progression and metastasis when overexpressed. High constitutive HMGA protein levels are among the most consistent feature observed in all types of cancers with increasing concentrations being correlated with increasing malignancy. (Review in Gene 2001 277:63-81)
C20326	HMGB_Family_Protein	Canonical_HMG_Protein	HMGB Family Protein|HMG-1/-2|HMG-Box Protein	The HMG-Box Family proteins are relatively abundant vertebrate DNA-binding and bending proteins that bind with structure specificity, rather than sequence specificity, and plays an architectural role in the assembly of nucleoprotein complexes. They have two homologous HMG-box DNA-binding domains connected by a short basic linker to an acidic carboxy-terminal tail that differs in length. The length (and possibly sequence) of the acidic tail may be the dominant factor in mediating the differences in properties among themselves and finely tunes the DNA-binding properties of the tandem HMG boxes, to fulfill different cellular roles. The tail is essential for structure-selective DNA-binding of the HMG boxes to DNA minicircles in the presence of equimolar linear DNA, and has little effect on the affinity for this already highly distorted DNA ligand, in contrast to binding to linear and four-way junction DNA. (J Mol Biol 2000 304:135-49)
C20327	HMGN_Family_Protein	Canonical_HMG_Protein	HMGN Family Protein|HMG-14/-17|NBD Protein	The high mobility group N (HMGN) proteins are a family of nuclear proteins that binds to nucleosomes, changes the architecture of chromatin, and enhances transcription and replication from chromatin templates. They typically contain an NBD (Nucleosome Binding Domain) motif, which anchors these HMG proteins to the nucleosome cores to facilitate HMG-14/-17-dependent changes in higher order chromatin structure.  The intracellular organization of the HMGN (previously known as HMG-14/17) proteins is dynamic and is related to both cell-cycle and transcriptional events. These proteins roam the nucleus, perhaps as part of multiprotein complexes, and their target interactions are modulated by posttranslational modifications. Functional studies on HMGN proteins provide insights into the molecular mechanisms by which structural proteins affect DNA-dependent activities in the context of chromatin. (Trends Biochem Sci 2001 Jul;26(7):431-7)
C20328	HMGB1	HMGB_Family_Protein	HMGB1|Amphoterin|Chromosomal Protein, Nonhistone, HMG1|HMG 1|HMG-1|HMG1|HMG3|High Mobility Group Protein 1|High-Mobility Group (Nonhistone Chromosomal) Protein 1|High-Mobility Group Box 1|Nonhistone Chromosomal Protein HGM1|SBP-1|Sulfoglucuronyl Carbohydrate Binding Protein	HMGB1 is a very abundant and conserved 25-kD protein which plays a central role in the stabilization and/or assembly of several nucleoprotein multifunctional complexes through protein-protein interactions. HMGB1 is essential in a variety of DNA-related biological processes, e.g., V(D)J recombination, the initiation of transcription, and DNA repair. HMGB1 binds DNA without sequence specificity, but has a high affinity for bent or distorted DNA, and bend linear DNA. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. HMGB1 is structured into two DNA-binding HMG-box domains (A and B) plus a long highly acidic C-terminal domain. The individual A and B boxes exhibit many of the structure-specific properties of the whole protein and the acidic tail modulates the affinity of the tandem HMG boxes in HMGB1 for a variety of DNA targets. (PMID 11497996, PMID 11748221)
C20329	HMGB3	HMGB_Family_Protein	HMGB3|HMG 2a|HMG-2a|HMG-4|HMG2a	HMGB3, encoded by the human HMGB3 Gene, is an high mobility group (HMG) protein, containing 2 HMG box repeats and an acidic C-terminal domain. HMGB3 is expressed predominantly in placenta. (From OMIM and NCI)
C20330	HMGB2	HMGB_Family_Protein	HMGB2|Chromosomal Protein, Nonhistone, HMG2|HMG 2|HMG-2|HMG2|HMGB2 Protein|High Mobility Group Box 2|High Mobility Group Protein 2|High-Mobility Group (Nonhistone Chromosomal) Protein 2|High-Mobility Group Box 2|Nonhistone Chromosomal Protein HMG2	HMGB2 contains two DNA-binding HMG-box domains (A and B) and a long acidic C-terminal domain. It binds DNA without sequence specificity, but has a high affinity for bent or distorted DNA, and bend linear DNA. The individual A and B boxes (which, although broadly similar, show both structural and functional differences) exhibit many of the structure-specific properties of the whole protein. The acidic tail modulates the affinity of the tandem HMG boxes in HMG2 for a variety of DNA targets, including four-way junctions, but not distorted DNA minicircles, to which the proteins bind with very high affinity. HMGB2 appears to play important architectural roles in the assembly of nucleoprotein complexes in a variety of biological processes, for example V(D)J recombination, the initiation of transcription, and DNA repair. (Biochem Soc Trans 2001 Aug;29(Pt 4):395-401)
C20331	HMGA1c	HMGA_Family_Protein	HMGA1c|HMG-I/R|HMGA1	HMGA1c appears to be the only isoform present in normal human testis.
C20332	HMGN3_Protein	HMGN_Family_Protein	HMGN3 Protein|HMGN3|High Mobility Group Nucleosomal Binding Domain|High Mobility Group Nucleosomal Binding Domain 3|High-Mobility Group Protein HMGN3|PNAS-24|TRIP7|Thyroid Hormone Receptor Interacting Protein 7|Thyroid Hormone Receptor Interactor 7	Many vertebrates contain an additional type of HMGN protein named HMGN3 (Trip7). HMGN3a and HMGN3b are two protein isoforms with a tissue-specific expression pattern. Unique within the HMGN family, the HMGN3 transcript undergoes alternative splicing and generates two different variants, HMGN3a and HMGN3b. The shorter variant, HMGN3b, arises from an additional splice site that truncates exon V and causes a frameshift. The resulting HMGN3b protein lacks the majority of the C-terminal chromatin-unfolding domain. Both splice variants are found in many vertebrates from frogs to man and are expressed in many tissues. The pattern of tissue-specific expression differs considerably from those of HMGN1 and HMGN2 at both the mRNA and the protein level. It is possible that these nucleosome-binding proteins function as co-activators in tissue-specific gene expression. (J Biol Chem 2001 Jul 13;276(28):25959-69)
C20333	HMGN4	HMGN_Family_Protein	HMGN4|HMG17L3|HMGN4 Protein|High Mobility Group Nucleosomal Binding Domain 4|High Mobility Group Protein N4|High-Mobility Group Nucleosome Binding Domain 4|High-Mobility Group Protein 17-Like 3|MGC5145|NHC|Non-Histone Chromosomal Protein|Nonhistone Chromosomal Protein HMG-17-Like 3	HMGN4, a newly discovered nuclear protein encoded by an intronless gene, is closely related to the canonical HMGN2 nucleosome-binding protein. (DNA Cell Biol 2001 May;20(5):257-64)
C20334	XRCC2_Gene	DNA_Repair_Gene	XRCC2 Gene|DNA Repair Protein XRCC2 Gene|X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 2 Gene|X-Ray Repair Cross Complementing Protein 2 Gene|XRCC2	The XRCC2 gene at chromosome 7q36.1 encodes X-Ray Repair Cross Complementing Protein 2, a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is essential for the efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. XRCC2 also may have a role in meiosis. (from OMIM 600375, LocusLink 7516 and NCI)
C20335	XRCC3_Gene	DNA_Repair_Gene	XRCC3 Gene|DNA Repair Protein XRCC3 Gene|X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 Gene|X-Ray Repair Cross-Complementing Protein 3 Gene|X-Ray Repair, Complementing Defective, in Chinese Hamster, 3 Gene|XRCC3	The XRCC3 gene at 14q32.3 encodes X-Ray Repair Cross Complementing Protein 3 (XRCC3), a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC3 interacts directly with RAD51 and may cooperate with RAD51 during recombinational repair. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity and exposure to UV radiation is a major risk factor for the development of malignant melanoma. DNA damage caused by UV radiation is thought to play a major role in carcinogenesis. The association between polymorphisms in DNA repair genes and the development of malignant melanoma, a T allele at position 18067 in exon 7 of the XRCC3 gene is significantly associated with melanoma development. (from OMIM 600675, LocusLink 7517 and NCI)
C20336	Telomere_Length_Maintenance	Telomere_Maintenance	Telomere Length Maintenance|Length Maintenance	Telomeres in human cancer cells consist of a tandem array of telomeric DNA repeats bound to a specialized telomeric proteins. Telomeres allow cells to distinguish natural chromosome ends from damaged DNA. When telomere function is disrupted, a potentially lethal DNA damage response can ensue, DNA repair activities threaten the integrity of chromosome ends, and extensive genome instability can arise. Both telomerase and recombination can lengthen telomeres. (from PMID 11850780 and NCI)
C20337	PRKDC_Gene	DNA_Repair_Gene	PRKDC Gene|DNAPK|DNAPK Gene|DNPK1|DNPK1 Gene|HYRC1|HYRC1 Gene|Hyper-Radiosensitivity Of Murine SCID Mutation, Complementing 1 Gene|PRKDC|Protein Kinase, DNA-Activated, Catalytic Polypeptide Gene|XRCC7|XRCC7 Gene|p350|p350 Gene	The PRKDC gene at 8q11 encodes Protein Kinase, DNA-Activated, Catalytic Subunit (PRKDC), a nuclear protein serine/threonine kinase of a multiprotein complex DNA-dependent protein kinase (DNA-PK). Two protein isoforms are produced by alternative splicing and binds DNA for catalysis. PRKDC relies on the heterodimer Ku70/Ku80 autoantigen, the DNA-binding DNA-PK component, to direct it to DNA double-stranded breaks for other discontinuities in the DNA double helix and trigger its kinase activity. PRKDC is critical for repair of DNA double strand breaks via the nonhomologous DNA end joining, telomere maintenance via telomere capping, innate immune response via V(D)J recombination (where V is variable, D is diversity, and J is joining) as well as transcriptional regulation via p53, the site-specific recombination process in developing B and T lymphocytes to generate the variable regions of immunoglobulin and T cell receptor genes.
C20338	Telomere_Maintenance_Gene	Gene	Telomere Maintenance Gene	Telomere Maintenance Genes encode specialized proteins bound to telomeric DNA repeats and directly involved in maintaining/protecting chromosome telomere ends to prevent a damage response that halts cell proliferation. Telomerase, which lengthens telomeric DNA by RNA-templated addition of repeated DNA sequences, is regulated by proteins that bind to the telomeric DNA repeats and to additional proteins to assemble a higher-order telomeric complex. (NCI)
C20339	Telomere_Capping	Telomere_Maintenance	Telomere Capping	Telomere capping protects chromosome ends from cellular DNA-damage responses, such as cell cycle arrest or apoptosis. Telomere capping involves multiple molecular pathways and at least four distinct structural components contribute to telomere capping: (1) the higher order telomeric DNA-protein complex, whose overall length (i.e., the number of telomeric repeats) dictates whether telomerase or nuclease can access telomeric DNA; (2) the protein complex found on the terminal few repeats; (3) the DNA-protein complex on the single stranded G-rich DNA extension of the telomere, which is most likely important for preventing DNA damage response and regulating the cell cycle dependent structure of the telomere; and (4) telomerase itself. Telomere capping is influenced by multiple, mutually reinforcing factors including telomere length, although telomere length is only one of several determinants of telomere functionality. (from PMID 11850780 and NCI)
C20340	Telomere_Recombination	Telomere_Length_Maintenance	Telomere Recombination|Telomere-Telomere Recombination	Recombination can lead to the net elongation of telomeres. The sequence at the ends of chromosomes is highly repetitive and is identical on all telomeres in a given species. The 3-prime end of one chromosome can invade a second chromosome and use the sequence of the second chromosome as a template for telomere elongation by DNA polymerase. The lagging strand can then be filled in by conventional replication mechanisms. (http://www.new-science-press.com/content/render.asp?options=nspprimer&arx_id=nsp-telomeres)
C20341	Elongation_by_Telomerase	Telomere_Length_Maintenance	Elongation by Telomerase	Most telomeres are maintained by telomerase. The enzymatic activity of telomerase lengthens terminal regions of eukaryotic telomeric DNA by RNA-templated addition of repeated DNA sequences to compensate for sequence loss as the cells divide. Telomerase specifically elongates the 3-prime end of a single-stranded overhang region on the G-rich 3-prime strand while the C-rich strand can be filled in by DNA polymerases. (NCI)
C20342	Internet	Telecommunications	Internet	A worldwide, decentralized network of computer networks connecting individuals and organizations to information and electronic mail services.
C20343	Human_Glandular_Kallikrein	Kallikrein	Human Glandular Kallikrein	The glandular kallikrein gene family comprises 25-30 homologous genes that encode specific proteases involved in the processing of biologically active peptides.  Expression of glandular kallikrein, like PSA, seems to be restricted to the prostate. (from OMIM 147960 and NCI)
C20344	OGG1_Gene	DNA_Repair_Gene	OGG1 Gene|8-Oxoguanine DNA Glycosylase Gene|MMH Gene|MUTM Gene|N-Glycosylase/DNA Lyase Gene|OGG1|OGH1 Gene	The OGG1 gene (OGG1 family 1) encodes 8-Oxoguanine DNA Glycosylase, an enzyme in base excision repair. OGG1 incises DNA at 8-oxoguanine residues and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-n-methylformamidopyrimidine (FAPY) from damaged DNA. OGG1 also has activities of beta-lyase that nicks DNA 3-prime to the lesion and endonuclease that cleaves DNA near apurinic or apyrimidinic sites to products with 5-prime-phosphate. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common (1a/alpha, 1b, 1c, 2a/beta, 2b, 2c, 2d and 2e) and 1a is the prevalent form. OGG1 is ubiquitous and located in nucleus (isoform 1a) and mitochondria (isoform 2a). Defects in OGG1 are associated with tumor formation.
C20345	EXO1_Gene	DNA_Repair_Gene	EXO1 Gene|EXO1|Exonuclease 1 Gene|HEX1|HEX1 Gene	The EXO1 gene at chromosome 1q42-q43 encodes Exonuclease 1, a protein with 5-prime to 3-prime double strand DNA exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different protein isoforms, a and b. (From LocusLink)
C20346	Atomic_Resolution_Microscopy	Microscopy	Atomic Resolution Microscopy|Atomic Scale Microscopy	Atomic Resolution Microscopy (or Scanning probe microscopy, SPM) covers several related technologies for imaging and measuring surfaces on a fine scale, down to the level of molecules and groups of atoms. SPM technologies share the concept of scanning an extremely sharp tip (3-50 nm radius of curvature) across the object surface. The tip is mounted on a flexible cantilever, allowing the tip to follow the surface profile. When the tip moves in proximity to the investigated object, forces of interaction between the tip and the surface influence the movement of the cantilever. Various interactions can be studied depending on the mechanics of the probe. Specialized sensors detect and record the movements of the cantilever providing an image with resolution at the atomic level. The techniques in this class can be grouped further into two subclasses: Scanning Tunneling Microscopy and Scanning Force Microscopy.
C20347	Apoptosis_Inhibitor_Gene	Apoptosis_Regulation_Gene	Apoptosis Inhibitor Gene	Apoptosis Inhibitor Genes encode Apoptosis Inhibitor proteins, which impede the initiation, progress, or rate of apoptosis. (NCI)
C20348	Apoptosis_Promoter_Gene	Apoptosis_Regulation_Gene	Apoptosis Promoter Gene	Apoptosis Promoter Genes encode Apoptosis Promoter proteins, which promote the initiation, progress, or rate of apoptosis. (NCI)
C20349	M-Phase	Cell_Cycle_Stage	M Phase|M Stage|Mitosis Stage	The last cell cycle stage during which the replicated daughter chromosomes separate in to separate nuclei; cytokinesis then occurs to produce separate daughter cells. M phase consists of Prophase, Metaphase, Anaphase, and Telophase. (NCI)
C20350	BIRC5_Gene	IAP_Family_Gene	BIRC5 Gene|API4|BIRC5|Baculoviral IAP Repeat-Containing 5 Gene|EPR-1|IAP4|Survivin	The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) family expressed during the G2/M phase of the cell cycle. BIRC5 is an interloper between cell death and cell proliferation in cancer. BIRC5 associates with the microtubules of the mitotic spindle during mitosis and any disruption results in the loss of antiapoptosis activity. BIRC5 inhibits apoptosis in B lymphocyte precursors deprived of interleukin 3 (IL-3) and may inhibit apoptosis in transformed cells. (NCI)
C20351	MAGE_Family_A_Gene	Retired_Concepts	MAGE Family A Gene|Melanoma Antigen Family A Gene
C20352	BIRC6_Gene	IAP_Family_Gene	BIRC6 Gene|Apollon Gene|BIRC6|Baculoviral IAP Repeat-Containing 6 Gene|Baculoviral IAP Repeat-Containing Protein 6 Gene|KIAA1289	The BIRC6 gene is a member of the IAP (inhibitors of apoptosis proteins) family and the ubiquitin-conjugating enzyme family. It is ubiquitously expressed as a 15-kb transcript. The protein encoded by the BIRC6 gene is expressed as a 530-kD protein in gliomas and ovarian cancers. BIRC6 may protect cancer cells from undergoing apoptosis and resist to apoptosis in the presence of anticancer drugs. BIRC6 contains a 70-amino acid cysteine- and histidine-rich baculovirus IAP repeat (BIR) and a zinc-binding RING finger.
C20353	BIRC7_Gene	IAP_Family_Gene	BIRC7 Gene|BIRC7|Baculoviral IAP Repeat-Containing 7 Gene|Baculoviral IAP Repeat-Containing Protein 7 Gene|KIAP|LIVIN|ML-IAP|MLIAP	The protein encoded by the BIRC7 gene is a potent anti-cell death protein and caspase inhibitor. BIRC7 has pleiotropic effects on apoptosis induced by various stimuli. BIRC7's antiapoptotic activity is achieved by two separate mechanisms: one requiring TAK1-dependent JNK1 activation and the second involving caspase inhibition. Upon receipt of a death stimulus, SMAC is processed to its active form and interacts with the BIR (baculovirus IAP repeat) domain of BIRC7 to abrogate the ability of BIRC7 to inhibit apoptosis. Two splicing variants, alpha and beta, have different biological properties and tissue distribution pattern though both have a significant antiapoptotic activity. The BIRC7 gene is located at chromosome 20q13.3 on the long arm of chromosome 20.
C20354	BIRC1_Gene	IAP_Family_Gene	BIRC1 Gene|BIRC1|Baculoviral IAP Repeat-Containing 1 Gene|NAIP	This gene is part of a 500 kb inverted duplication on chromosome 5q13. This duplicated region contains at least four genes and repetitive elements which make it prone to rearrangements and deletions. This copy of the gene is full length; additional copies with truncations and internal deletions are also present in this region of chromosome 5q13. This gene is a modifier of spinal muscular atrophy caused by mutations in a neighboring gene, SMN1. The protein encoded by this gene contains regions of homology to two baculovirus inhibitor of apoptosis proteins, and it is able to suppress apoptosis induced by various signals and inhibits apoptosis in neuronal cells.
C20355	BIRC2_Gene	IAP_Family_Gene	BIRC2 Gene|API1|BIRC2|Baculoviral IAP Repeat-Containing 2 Gene|CIAP1|HIAP2|MIHB|Mammalian IAP Homolog B	The protein encoded by this gene is a member of the inhibitor of apoptosis (IAP) protein family that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 preventing activation of ICE-like proteases. BIRC2 inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain.
C20356	BIRC3_Gene	IAP_Family_Gene	BIRC3 Gene|API2|Apoptosis Inhibitor 2 Gene|BIRC3|Baculoviral IAP Repeat-Containing 3 Gene|Baculoviral IAP Repeat-Containing Protein 3 Gene|CIAP2|HIAP1|IAP Homolog C|MIHC|Mammalian IAP Homolog C	The protein encoded by this gene is a member of a family of proteins that inhibits apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. BIRC3 inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring-type zinc finger domain while the Zn binding domain is involved in protein-protein interactions in caspase inhibition and spindle assembly. BIRC3 is present in many fetal and adult tissues and mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes.
C20357	BIRC4_Gene	IAP_Family_Gene	BIRC4 Gene|API3|BIRC4|Baculoviral IAP Repeat-Containing 4 Gene|ILP|MIHA|XIAP	The protein encoded by this gene is a member of a family of proteins which inhibit apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Similar to BIRC2, BIRC4 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. BIRC4 also specifically inhibits two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. A novel transcript homologous to BIRC4 is expressed solely in the testis.
C20358	APAF1_Gene	Apoptosis_Promoter_Gene	APAF1 Gene|APAF1|Apoptotic Protease Activating Factor 1 Gene|KIAA0413	Caspases are a highly conserved family of cysteine proteases that cleave their substrates after an aspartate residue. They play fundamental roles in the initiation and execution of apoptosis. The protein encoded by the APAF1 gene mediates processing of procaspase-9 by oligomerizing the precursors of procaspase-9 autoactivation. Once activated, caspase-9 initiates a biochemical cascade involving the downstream executioners caspase-3, -6, and -7. In addition, binding of cytochrome c to APAF1 triggers the activation of caspase-3 in the cytochrome c/dATP-dependent apoptotic pathway. APAF1 is inactivated in metastatic melanomas, leading to defects in the execution of apoptotic cell death and chemoresistance.
C20359	TOPBP1_Gene	DNA_Repair_Gene	TOPBP1 Gene|DNA Topoisomerase II Binding Protein Gene|Hypothetical Protein KIAA0259 Gene|KIAA0259 Gene|TOPBP1|Topoisomerase (DNA) II Binding Protein Gene	The TopBP1 gene at chromosome 3q22.2 encodes Topoisomerase (DNA) II Binding Protein (TOPBP1), a 173-kD binding protein which interacts with the C-terminal region of topoisomerase II beta. TOPBP1 may stimulate catalytic activity of topoisomerase II beta through transient breakages of DNA strands. (From LocusLink)
C20360	FLJ20174_Gene	Gene_with_Unknown_or_Unclassified_Function	SIDT1 Gene|FLJ20174|SID1|SID1 Transmembrane Family, Member 1 Gene|SID1 transmembrane family, member 1|SIDT1	Human FLJ20174 Gene at 3q13.2 encodes Hypothetical Protein FLJ20174, a potential homolog of sid-1 (C. elegans), a predicted transmembrane protein localized to the cell periphery, and required cell autonomously for systemic RNA interference (RNAi). (NCI)
C20361	XPA_Gene	DNA_Repair_Gene	XPA Gene|XP, Group A|XP, Group A Gene|XP1|XP1 Gene|XPA|XPA Complementing Gene|XPA Correcting Gene|XPAC|XPAC Gene|Xeroderma Pigmentosum I Gene|Xeroderma Pigmentosum, Complementation Group A Gene	The XPA gene at chromosome 9q22.3 encodes DNA-Repair Protein Complementing XP-A Cells (XPA), the nuclear protein that has a zinc finger domain and is involved in the DNA excision repair pathway. XPA initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. XPA complements the defect in xeroderma pigmentosum (XP) group A (XP-A), an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders.
C20362	XRCC4_Gene	DNA_Repair_Gene	XRCC4 Gene|X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 4 Gene|XRCC4	The XRCC4 gene at chromosome 5q13-q14 encodes X-Ray Repair Cross Complementing Protein 4 (XRCC).  XRCC functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. The XRCC4 gene contains 8 exons, and alternative transcription initiation and alternative splicing generates several transcript variants and two protein isoforms. XRCC4 is a ubiquitously expressed protein. (NCI)
C20363	XRCC5_Gene	Ku_Subunit_Gene	XRCC5 Gene|G22P2|Ku Antigen, 80-Kd Subunit Gene|Ku80|X-ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining; Ku Autoantigen, 80kDa) Gene|XRCC5	The XRCC5 gene at 2q35 encodes a DNA repair protein XRCC5 that is ATP-dependent DNA helicase II and the 80-kilodalton subunit of the Ku heterodimer protein. It has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner and works in the 3-prime to 5-prime direction. Ku binds to free double-stranded DNA ends and Ku is the DNA-binding component of the DNA-dependent protein kinase. The Ku protein functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Individuals with SLE and related disorders produce extremely large amounts of autoantibodies to Ku subunits. (from LocusLink 7520, Swiss_Prot P13010 and NCI)
C20364	Small_Inducible_Cytokine-C1	Gamma_Chemokine	Small Inducible Cytokine C1|Chemokine (C Motif) Ligand 1|Lymphotactin|Single Cysteine Motif 1|Single Cysteine Motif 1A|XCL1	Expressed in activated CD8+ T cells, in spleen, thymus, small intestine, lung, prostate, and ovary by human XCL1 Gene (Intercrine Gamma Family), 114-aa 12.5-kDa (precursor) secreted Small Inducible Cytokine C1 is similar to CCL8 and CCL3, but lacks the first and third cysteines of CC and CXC chemokines. XCL1 differs from XCL2 (separate gene) by only 2 amino acids; XCL1 encodes Asp7, Lys8 (mature protein) instead of His, Arg as in XCL2. XCL1 is chemotactic for CD4+ and CD8+ T cells, but not for monocytes or neutrophils, and induces increased intracellular calcium in peripheral lymphocytes; XCL1 induces migration of cells expressing XCR1. Small (8-14 kD), mostly basic, chemokines interact with 7-transmembrane G protein-coupled receptors and regulate cell trafficking of leukocytes, as well as development, homeostasis, and immune system function. (NCI)
C20365	Replication_Licensing	Replication-Associated_Process	Replication Licensing	The exact duplication of a genome once per cell division is required of every proliferating cell. To achieve this goal, eukaryotes adopt a strategy that limits every replication origin to a single initiation event within a narrow window of the cell cycle by temporally separating the assembly of the pre-replication complex (pre-RC) from the initiation of DNA synthesis. A key component of the pre-RC is the hexameric MCM complex. An elaborate mechanism recruits the MCM complex to replication origins, and a regulatory chain reaction converts the poised, but inactive, MCM complex into an enzymatically active helicase. (from PMID 11282021 and NCI)
C20366	Diaphranography	Medical_Imaging	Diaphranography	Diaphranography (transillumination light scanning) is a non-invasive imaging procedure for the detection and evaluation of breast disease, by visualizing lesions through a television camera sensitive to infrared light. Diaphranography has been demonstrated to be a useful adjunct to mammography.
C20367	MCM_Protein	DNA_Replication_Factor	MCM Protein	The MCM proteins are essential replication initiation factors. The best known among them are a family of six structurally related proteins, MCM2-7, which are evolutionally conserved in all eukaryotes. The MCM2-7 proteins form a hexameric complex. This complex is a key component of the prereplication complex that assembles at replication origins during early G1 phase. The MCM2-7 proteins may be involved not only in the initiation but also in the elongation of DNA replication. Orchestration of the functional interactions between the MCM2-7 proteins and other components of the prereplication complex by cell cycle-dependent protein kinases results in initiation of DNA synthesis once every cell cycle. (from PMID 10872463 and NCI)
C20368	Research_Techniques	Techniques	Research Techniques	Techniques used in the laboratory for scientific research.(NCI2005)
C20369	Microtechniques	Research_Techniques	Microtechniques	Laboratory techniques required for preparation of tissues for light microscopy/histological analysis to study the microscopic structure of animal tissues, including their cellular composition, origin, differentiation, function and arrangement into organs. (NCI2005)
C20370	Replication_Initiation_Gene	Gene	Replication Initiation Gene	Replication Initiation Genes encode proteins directly involved in initiation of DNA replication. (NCI)
C20371	ORC_Subunit_Gene	Replication_Initiation_Gene	ORC Subunit Gene	DNA replication is initiated by the Origin Recognition Complex (ORC). ORC is composed of six protein subunits and binds to the ARS Consensus Sequence (ACS) of Origins of Replication in an ATP-dependent manner. While ORC remains bound to origins throughout the cell cycle, the binding of ORC and other factors modulates local chromatin structure to facilitate replication initiation. All 6 genes encoding ORC (ORC1 through ORC6) may be required for initiation of DNA replication and are essential for viability.
C20372	Licensing_Factor_Gene	Replication_Initiation_Gene	Licensing Factor Gene	Licensing Factor Genes encode Licensing Factors that are required, after a prior round of mitosis, in G(1) for DNA replication licensing, are removed after passage through S-phase, and are central to ensuring that replication occurs once per cell cycle. (NCI)
C20373	MCM2_Gene	Licensing_Factor_Gene	MCM2 Gene|BM28 Gene|CCNL1 Gene|CDCL1 Gene|Cell Devision Cycle-Like 1 Gene|Cyclin-Like 1 Gene|D3S3194 Gene|DNA Replication Licensing Factor MCM2 Gene|KIAA0030 Gene|MCM2|MCM2 Minichromosome Maintenance Deficient 2, Mitotin (S. Cerevisiae) Gene|MGC10606 Gene|Minichromosome Maintenance Protein 2 Gene|Mitotin Gene|Nuclear Protein BM28 Gene|cdc19 Gene	The MCM2 gene at 3q21 encodes a 100-kD nuclear protein that is a member of the MCM family. MCM2 allows the DNA to undergo a single round of replication per cell cycle and is required for the entry in S phase and for cell division. MCM4, MCM6, and MCM7 form a stable complex with which MCM2 is loosely associated. The trimeric complex of MCM4, -6, and -7 has ATPase and DNA helicase activities, which is involved in the initiation of DNA replication as a DNA unwinding enzyme. The presence of MCM2 disturbs the assembly of MCM4, MCM6, and MCM7 proteins to inhibit the DNA helicase activity. Through specific binding of MCM2 with histone H3, the complex binds chromatin. In addition, the CDC7L1 kinase complex triggers S phase by directly activating the replication initiation complex assembled at the origins. Phosphorylation of MCM2 and MCM3 in the MCM complex by the CDC7L1 kinase complex converts the inactive MCM complex into an active helicase.
C20374	MCM4_Gene	Licensing_Factor_Gene	MCM4 Gene|MCM4|MCM4 Minichromosome Maintenance Deficient 4 (S. Cerevisiae) Gene	The MCM4 gene at 8q12-q13 encodes a 97-kD protein that is a member of the MCM family. MCMs are a family of proteins related to ATP-dependent helicases that bind to origin recognition complexes and are required not only for the initiation of DNA replication but also for preventing over-replication in eukaryotic cells. MCM4 forms a stable complex with MCM6 and MCM7 and is loosely associated with MCM2. Through specific binding of MCM2 with histone H3, the complex binds chromatin. Both ATPase and DNA helicase activities are associated with the trimeric MCM4, -6, and -7 complex, which may be involved in the initiation of DNA replication as a DNA unwinding enzyme. MCM4 is highly phosphorylated in mitotic cells and phosphorylation of the amino-terminal region of MCM4 at specific sites by the cyclin A/Cdk2 leads to loss of MCM4, -6, -7 DNA helicase activity. This inactivation of helicase activity is a part of the system for regulating DNA replication. (NCI)
C20375	MCM5_Gene	Licensing_Factor_Gene	MCM5 Gene|CDC46|Cell Division Cycle 46|MCM5|MCM5 Minichromosome Maintenance Deficient 5, Cell Division Cycle 46 (S. Cerevisiae) Gene	The MCM5 gene at 22q13.1 encodes a 82-kD protein that is a member of the MCM family. MCMs are a family of proteins related to ATP-dependent helicases that bind to origin recognition complexes and are required for initiation of DNA replication. Essentially all nuclear MCM5 forms a stable dimeric complex with MCM3 and MCM3 is associated with the replication-specific DNA polymerase alpha-primase complex. MCM3 acetylation by an acetyltransferase MCM3AP might regulate DNA replication. In addition, MCM proteins are associated with RNA polymerase II (Pol II) holoenzyme as components of the Pol II transcriptional apparatus for transcription. MCM5 directly interacts with the transcription activation domain (TAD) of Stat1 and enhances Stat1-mediated transcription activation. The growth-regulated expression of the MCM5 gene is primarily regulated by E2F through binding to multiple E2F sites in the promoter.
C20376	MCM6_Gene	Licensing_Factor_Gene	MCM6 Gene|MCM6|MCM6 Minichromosome Maintenance Deficient 6 (MIS5 Homolog, S. Pombe) (S. Cerevisiae) Gene	The MCM6 gene at 2q21 encodes a 105-kD protein that is a member of the MCM family. MCMs are related to ATP-dependent helicases that bind to origin recognition complexes and are required not only for the initiation of DNA replication but also for preventing over-replication in eukaryotic cells. MCM6 forms a stable complex with MCM4 and MCM7. Both ATPase and DNA helicase activities are associated with the trimeric MCM4, -6, and -7 complex, which is involved in the initiation of DNA replication as a DNA unwinding enzyme. MCM6 is expressed in a wide variety of human adult and fetal tissues and not restricted in its tissue distribution. MCM6 transcription is repressed in quiescent cells but is rapidly induced at the G1/S phase by growth factor stimulation with four putative E2F binding motifs at the 5' regulatory region of the promoter. MCM6 protein level oscillates during the cell cycle, with a peak at the G1/S phase. (NCI)
C20377	MCM3_Gene	Licensing_Factor_Gene	MCM3 Gene|MCM3|MCM3 Minichromosome Maintenance Deficient 3 (S. Cerevisiae) Gene|RLFB	The MCM3 gene at 6p12 encodes Minichromosome Maintenance Protein 3, a 91-kD protein that is a member of the MCM family. MCMs are a family of proteins related to ATP-dependent helicases that bind to origin recognition complexes and are required for initiation of DNA replication. MCM3 is associated with the replication-specific DNA polymerase alpha-primase complex and MCM3 acetylation by an acetyltransferase MCM3AP might regulate DNA replication. In addition, MCM proteins are associated with RNA polymerase II (Pol II) holoenzyme as components of the Pol II transcriptional apparatus for transcription. MCM3 complexes with essentially all nuclear MCM5 to form a stable dimeric and MCM5 directly interacts with the transcription activation domain (TAD) of Stat1 to enhance Stat1-mediated transcription activation. (NCI)
C20378	MCM7_Gene	Licensing_Factor_Gene	MCM7 Gene|CDC47|MCM2, Formerly|MCM7|MCM7 Minichromosome Maintenance Deficient 7 (S. Cerevisiae) Gene	The MCM7 gene at 7q21.3-q22 encodes a 81-kD protein of the MCM family. MCMs are ATP-dependent helicases that bind to origin recognition complexes and required for the initiation of DNA replication as well as for preventing over-replication. MCM6 forms a stable complex with MCM4 and MCM7. The trimeric MCM4, -6, and -7 complex is involved in the initiation of DNA replication as a DNA unwinding enzyme. At the final step in sequential assembly of an active initiation complex, CDC45 binds directly to MCM7 and the p70 subunit of DNA polymerase alpha. The p70 subunit, which has no enzymatic activity, forms a tight complex with the p180 catalytic subunit of DNA polymerase alpha. CDC45 leads DNA polymerase alpha, the only enzyme capable of starting DNA synthesis de novo, to the origins of DNA replication through binding with MCM7 and the p70 subunit. MCM7 transcription is a direct target of the MYCN oncoprotein in neuroblastoma. (NCI)
C20379	CDC45L_Gene	Replication_Initiation_Gene	CDC45L Gene|CDC45|CDC45 Cell Division Cycle 45-Like (S. Cerevisiae) Gene|CDC45-Like|CDC45L|CDC45L2|Cell Division Cycle 45-Like 2|PORC-PI-1	The CDC45L gene at 22q11.2 encodes a 66-kD protein that interacts with MCM7 and DNA polymerase alpha in the loading of DNA polymerase alpha onto chromatin at the final step in sequential assembly of an active initiation complex for replication. CDC45 binds directly to the p70 subunit of DNA polymerase alpha, which has no enzymatic activity. CDC45 may lead DNA polymerase alpha, the only enzyme capable of starting DNA synthesis de novo, to the origins of DNA replication through binding with MCM7 and the p70 subunit. CDC45 is widely expressed with highest levels in adult testis and thymus and in fetal liver. The level of Cdc45L mRNA peaks at G1-S transition, but total protein amount remains constant. CDC45 is expressed in multiple tissues during embryogenesis, including neural crest-derived structures. One copy of this gene is deleted in patients with DiGeorge syndrome. (From PMID and NCI).
C20380	ORC2L_Gene	ORC_Subunit_Gene	ORC2L Gene|ORC2|ORC2L|Origin Recognition Complex, Subunit 2-Like (Yeast) Gene	DNA replication is initiated by the Origin Recognition Complex (ORC). ORC is composed of six protein subunits and binds to the ARS Consensus Sequence (ACS) of Origins of Replication in an ATP-dependent manner. While ORC remains bound to origins throughout the cell cycle, the binding of ORC and other factors modulates local chromatin structure to facilitate replication initiation. All 6 genes encoding ORC (ORC1 through ORC6) may be required for initiation of DNA replication and are essential for viability. The protein encoded by the ORC2L gene is a 72-kD protein that forms a complex with ORC1L in vivo and has highest expression levels in testes. Expression of ORC2L is not regulated during different phases of cell proliferation. The human ORC2L gene is located at 2q33 on the long arm of chromosome 2.
C20381	CDT1_Gene	Licensing_Factor_Gene	CDT1 Gene|CDT1|DNA Replication Factor Gene|DUP|HCDT1	The CDT1 gene encodes DNA Replication Factor (CDT1), which is essential for DNA replication and chromatin licensing. Geminin inhibits inappropriate origin firing by targeting CDT1. CUL4 prevents aberrant reinitiation of DNA replication, at least in part, by facilitating the degradation of CDT1. (From LocusLink, OMIM and NCI)
C20382	CDC6_Gene	Licensing_Factor_Gene	CDC6 Gene|CDC18L|CDC6|CDC6 Cell Division Cycle 6 Homolog (S. Cerevisiae) Gene|CDC6 Homolog|CDC6/Cdc18|Cell Cycle Controller CDC6|HsCDC18|HsCDC6	The CDC6 gene encodes CDC6 Cell Division Cycle 6 Homolog, which is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cycle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cycle is regulated through its phosphorylation by Cdks. Transcription of this protein is regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. (From LocusLink and NCI)
C20383	MCM10_Gene	Replication_Initiation_Gene	MCM10 Gene|MCM10|MCM10 Minichromosome Maintenance Deficient 10 (S. Cerevisiae) Gene	The Mcm10 gene encodes a 98-kD protein that interacts with ORC and the MCM2-7 complex. MCM10 is not part of the MCM2-7 complex and shares no significant sequence homology with the MCM proteins in the complex. MCM10 may assist in releasing replication forks from the origin of replication through interactions with those proteins to release the MCM2-7 complex for triggering DNA replication. Though human MCM10 is not a component of the pre-replicative complex, it is involved in S phase progression. Human MCM10 binds chromatin during S phase and dissociates in G-2 phase. Human MCM10 is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. This gene is located at chromosome 10p13 on the short arm of chromosome 10.
C20384	CDC7_Gene	Replication_Initiation_Gene	CDC7 Gene|CDC7|CDC7 Cell Division Cycle 7 (S. Cerevisiae) Gene|CDC7L1|HsCDC7|Hsk1|huCDC7	The CDC7 gene encodes CDC7 Cell Division Cycle 7, which is predominantly localized in the nucleus and is a cell division cycle protein with kinase activity. Although expression levels of this protein appear constant throughout the cell cycle, the protein kinase activity appears to increase during S phase. This protein is essential for initiation of DNA replication and plays a role in regulating cell cycle progression. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Additional transcript sizes have been detected, suggesting the presence of alternative splicing. (From LocusLink and NCI)
C20385	ASK_Gene	Replication_Initiation_Gene	ASK Gene|ASK|ASK/H37|Activator of S Phase Kinase Gene|DBF4|DBF4 Homolog|HUDBF4	Growth factor and E2F-regulated, widely expressed (2.5-kb transcript) 33-kb 12-exon human ASK Gene at 7q21.3 encodes 674-aa 77-kD nuclear Activator of S Phase Kinase, a cyclin-like regulatory subunit of CDC7L1 kinase involved in G1/S transition. ASK mRNA and protein are low in G1, peak in S phase, and reduce in G2/M; ASK is extensively phosphorylated during S phase. Containing a bipartite NLS, conserved motifs N (N-terminus) and C (central region), and 2 PEST sequences, ASK appears essential for entry into S phase. Motif C is essential for CDC7L1 catalytic subunit interaction with ASK, a major activator of CDC7L1 kinase activity on MCM2.  (NCI)
C20386	ORC1L_Gene	ORC_Subunit_Gene	ORC1L Gene|ORC1|ORC1L|Origin Recognition Complex, Subunit 1-Like (Yeast) Gene	Transcriptionally repressed by E2F in quiescent cells and activated by G1 cyclin-dependent kinase growth stimulation, human ORC1L Gene (ORC1 Family) encodes 861-aa 97-kDa nuclear Origin Recognition Complex Subunit 1, the largest of 6 conserved subunits of the ORC complex that binds to the consensus ACS of Origins in an ATP-dependent manner, serves as a platform for assembly of additional initiation factors such as CDC6 and MCM proteins, initiates DNA replication, and is essential for viability. Bound to origins throughout the cell cycle, ORC and associated factors modulate local chromatin structure to facilitate replication initiation. Selectively phosphorylated during mitosis and unlike other ORC subunits, ORC1L levels vary during the cell cycle, regulated by ubiquitin-mediated proteolysis after replication initiation. Also involved in transcriptional silencing, ORC1L may interact with MYST histone acetyltransferase 2. (NCI)
C20387	ORC4L_Gene	ORC_Subunit_Gene	ORC4L Gene|ORC4L|Origin Recognition Complex, Subunit 4-Like (Yeast) Gene	DNA replication is initiated by the Origin Recognition Complex (ORC). ORC is composed of six protein subunits and binds to Origins of Replication. While ORC remains bound to origins throughout the cell cycle, the binding of ORC and other factors modulates local chromatin structure to facilitate replication initiation. All 6 genes encoding ORC (ORC1 through ORC6) may be required for initiation of DNA replication. The protein encoded by the ORC4L gene is a 50-kD protein that has a putative nucleotide triphosphate binding motif. ORC4L associates with multiple cellular proteins, including ORC2L, in vivo. The human ORC4L gene is located at chromosome 2q22-q23 on the long arm of chromosome 2.
C20388	ORC5L_Gene	ORC_Subunit_Gene	ORC5L Gene|ORC5L|Origin Recognition Complex, Subunit 5-Like (Yeast) Gene	DNA replication is initiated by the Origin Recognition Complex (ORC). ORC is composed of 6 protein subunits and binds to Origins of Replication. While ORC remains bound to origins throughout the cell cycle, the binding of ORC and other factors modulates local chromatin structure to facilitate replication initiation. All 6 genes encoding ORC (ORC1 through ORC6) are required for initiation of DNA replication. The ORC5 gene at 7q22.1 encodes the bulk of protein in an insoluble nuclear fraction. The alternatively spliced ORC5T protein forms a complex with ORC4L but not with ORC2L and regulates the assembly of different ORC subcomplexes. ORC5 and the alternatively spliced ORC5T transcripts are abundant in spleen, ovary, and prostate in addition to tissues with high levels of DNA replication like testes and colon mucosa. The ORC5L gene does not function as a tumor suppressor in patients with myeloid neoplasms. (from OMIM 602331 and NCI)
C20389	ORC6L_Gene	ORC_Subunit_Gene	ORC6L Gene|ORC6L|Origin Recognition Complex, Subunit 6 Homolog-Like (Yeast) Gene	DNA replication is initiated by the Origin Recognition Complex (ORC). ORC is composed of 6 protein subunits and binds to Origins of Replication in an ATP-dependent manner. While ORC remains bound to origins throughout the cell cycle, the binding of ORC and other factors modulates local chromatin structure to facilitate replication initiation. All 6 genes encoding ORC (ORC1 through ORC6) are required for initiation of DNA replication. The ORC6L gene at 16q12 encodes a 28-kD protein whose expression level does not change through the cell cycle. Like ORC1, ORC6 is localized in the nucleus along with the other ORC subunits but only a small fraction of human ORC1 and ORC6 is associated with a subcomplex of ORC2, 3, 4, and 5. ORC6 also co-immunoprecipitate with several cellular proteins, including a 65-kDa protein that is hyperphosphorylated in G(1) and dephosphorylated in mitosis. (from J Biol Chem and NCI)
C20390	ORC3L_Gene	ORC_Subunit_Gene	ORC3L Gene|LAT|ORC3|ORC3L|Origin Recognition Complex, Subunit 3-Like (Yeast) Gene	DNA replication is initiated by the Origin Recognition Complex (ORC). ORC is composed of 6 protein subunits and binds to Origins of Replication. While ORC remains bound to origins throughout the cell cycle, the binding of ORC and other factors modulates local chromatin structure to facilitate replication initiation. All 6 genes encoding ORC (ORC1 through ORC6) may be required for initiation of DNA replication. The ORC3L gene at 6q14.3-16.1 encodes an 80-kD protein that contains a nuclear localization signal and helix-loop-helix motifs. Human ORC2, -3, -4, and -5 form a core complex. The N-terminal region of ORC3 interacts directly with the C-terminal region of ORC2 and the C-terminal region of ORC3 is necessary to bring ORC4 and ORC5 into the core ORC2-5 complex. ORC3L is important for the G(1)-S transition in mammalian cells and might have other activities than replication initiation because it is also detected in non-proliferating cells. (NCI)
C20391	Neurotrophic_Factor	Growth_Factor	Neurotrophic Factor|Neurotrophin	family of polypeptide growth factors produced by peripheral target tissues as well as the nervous system, which are critical to neuronal growth, regeneration, survival, and differentiation. (CSP2000)
C20392	Neuropoietic_Cytokine	Neurotrophic_Factor	Neuropoietic Cytokine	Neuropoietic Cytokine glycoproteins act with high affinity through specific receptors as local paracrine or autocrine intercellular mediators to regulate neuronal growth, regeneration, survival, and differentiation.
C20393	Heparin-Binding_Neurotrophic_Factor	Neurotrophic_Factor	Heparin-Binding Neurotrophic Factor	Heparin-Binding Neurotrophic Factors are a family of polypeptide growth factors produced by peripheral target tissues, as well as the nervous system, that block apoptosis and promote neuronal growth, regeneration, survival, and differentiation. Many growth factors appear to temporarily and non-covalently interact with the glycosaminoglycan heparin, which may affect growth factor activity.
C20394	WNT_Family_Protein	Signaling_Protein	WNT Family Protein	Encoded by WNT Family Genes, secreted structurally related signaling WNT Family Proteins are implicated in oncogenesis and in several developmental processes, including regulation of cell fate and embryonic patterning. (NCI)
C20395	GMNN_Gene	Cell_Cycle_Gene	GMNN Gene|GMNN|Geminin Gene|Geminin, DNA Replication Inhibitor Gene	The geminin gene at 6p22.1 encodes a 25-kD protein that inhibits DNA replication during S, G2, and M phases by sequestering CDT1, a replication initiation factor necessary for MCM loading, to prevent the incorporation of MCM complex into prereplication complex. Geminin has a destruction box sequence (RRTLKVIQP) and is ubiquitinated by the anaphase-promoting complex. Geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Geminin may also inhibit inappropriate origin firing by targeting CDT1. In the normal cell cycle, CDT1 is present only in G1 and S phases, whereas geminin is present in S and G2 phases. (from OMIM 602842 and NCI)
C20396	Protein_Phosphatase-2A_Subunit_Gene	Protein_Serine-Threonine_Phosphatase_Gene	Protein Phosphatase 2A Subunit Gene	The Protein Phosphatase 2A Subunit Genes encodes 3 subunits (A, B, and C) of Protein Phosphatase 2A (PP2A) holoenzyme, a heterotrimeric serine/threonine phosphatase. The structural A subunit and the catalytic C subunit form a catalytic core, while substrate specificity is directed by the B subunit. PP2A exerts regulatory control over the initiation of DNA replication and has a particularly complex set of regulatory subunits controlling its function and localization.
C20397	PR48_Gene	Regulatory_Gene	PPP2R3B Gene|NY-REN-8|PPP2R3B|PR48|PR48 Gene|Protein Phosphatase 2 (Formerly 2A), Regulatory Subunit B'', Beta Gene	Human PR48 Gene (PP2A Regulatory Subunit B Family) encodes 414-aa nuclear Protein Phosphatase 2A 48kDa Regulatory Subunit, a B regulatory subunit of PP2A. PR48 specifically interacts with the N-terminal region of and dephosphorylates CDC6, modulating initiation of DNA replication and cell cycle control. A major heterotrimeric Ser/Thr phosphatase implicated in negative control of many cellular processes including cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A that may differ in substrate specificity, subcellular location, or tissue specific expression. (NCI)
C20398	PPP2CA_Gene	Protein_Phosphatase-2A_Subunit_Gene	PPP2CA Gene|PP2CA|PPP2CA	The PPP2CA gene at chromosome 5q23-q31 encodes a 36-kD protein and catalytic subunit that is common to all forms of Type 2A protein phosphatase (PP2A) PPP2CA forms two distinct complexes, alpha with a structural PR65/A subunit and beta with an alpha4 protein. The PR65/A-PPP2CA dimer may further associate with a third regulatory subunit (PR54, PR55, PR72, PR74, PR130, etc.) and form a specific trimeric holoenzyme. Three families of regulatory subunits control substrate selectivity and phosphatase activity and target PP2A holoenzymes to their substrates. Phosphorylation, carboxyl methylation, inhibition by intracellular protein inhibitors, and stimulation by ceramide also regulate PPP2CA function. Phosphorylation of either threonine or tyrosine results in inactivation of the phosphatase, whereas auto-dephosphorylation acts as a mechanism for reactivation. (NCI)
C20399	PPP2CB_Gene	Protein_Phosphatase-2A_Subunit_Gene	PPP2CB Gene|PP2CB|PPP2CB	Type 2A protein phosphatase (PP2A) comprises a diverse family of phosphoserine- and phosphothreonine-specific enzymes ubiquitously expressed in eukaryotic cells. PP2A dephosphorylates protein kinases and transcription factors, and regulates most major metabolic pathways, as well as translation, transcription, and control of transition from G2 to the M phase of the cell cycle. PP2A consists of three subunits, a catalytic C subunit and a structural/regulatory A subunit, which form the core enzyme, and a regulatory B subunit that binds to the core enzyme yielding the holoenzyme. Both the A and B subunits exist as two isoforms, alpha and beta. The combination of these different subunits could give rise to many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. The PPP2CB gene at 8p12-p11.2 encodes the beta isoform of the catalytic subunit of PP2A. (NCI)
C20401	Monoclonal_Antibody	Biological_Agent|Biological_Response_Modifier	Monoclonal Antibody|MAb|MoAB|Monoclonal Antibodies|monoclonal antibodies	(MAH-no-KLO-nul AN-tih-BAH-deez) Laboratory-produced substances that can locate and bind to cancer cells wherever they are in the body. Many monoclonal antibodies are used in cancer detection or therapy; each one recognizes a different protein on certain cancer cells. Monoclonal antibodies can be used alone, or they can be used to deliver drugs, toxins, or radioactive material directly to a tumor.
C20402	PPP2R5A_Gene	Protein_Phosphatase-2A_Subunit_Gene	PPP2R5A Gene|PPP2R5A	Ubiquitously expressed (heart and skeletal muscle highest), human PPP2R5A Gene (PP2A Subunit B Family) encodes serine phosphorylated 486-aa 56-kDa cytoplasmic Protein Phosphatase 2 Regulatory Subunit B Alpha, a subunit of PP2A. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI)
C20403	PPP2R5B_Gene	Protein_Phosphatase-2A_Subunit_Gene	PPP2R5B Gene|PPP2R5B|R5/B56	Type 2A protein phosphatase (PP2A) is a diverse family of phosphoserine- and phosphothreonine-specific enzymes ubiquitously expressed in eukaryotic cells. PP2A consists of three subunits, a catalytic C subunit and a structural A subunit, which form the core enzyme, and a regulatory B subunit that binds to the core enzyme yielding the holoenzyme. Both the A and B subunits exist as two isoforms, alpha and beta, whereas the B subunits fall into three families. The combination of these different subunits could give rise to many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. The PPP2R5B gene encodes the beta subunit in the B56 family of related PP2A regulatory subunits. The PPP2R5B gene at chromosome 11q13 is expressed at highest levels in the brain and the expression increases when neuroblastoma cells are induced to differentiate with retinoic acid. (from OMIM 601643 and NCI)
C20404	PPP2R5C_Gene	Protein_Phosphatase-2A_Subunit_Gene	PPP2R5C Gene|PPP2R5C	Type 2A protein phosphatase (PP2A) is a diverse family of phosphoserine- and phosphothreonine-specific enzymes ubiquitously expressed in eukaryotic cells.  PP2A consists of three subunits, a catalytic C subunit and a structural A subunit, which form the core enzyme, and a regulatory B subunit that binds to the core enzyme yielding the holoenzyme.  Both the A and B subunits exist as two isoforms, alpha and beta, whereas the B subunits fall into three families.  The combination of these different subunits could give rise to many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression.  The PPP2R5C gene at chromosome 14q32.2 encodes the gamma subunit in the B56 family of related PP2A regulatory subunits.  This gene is expressed at highest levels in skeletal and cardiac muscle and there are at least 3 splice variants. (NCI)
C20405	PPP2R5D_Gene	Protein_Phosphatase-2A_Subunit_Gene	PPP2R5D Gene|PPP2R5D	Type 2A protein phosphatase (PP2A) is a diverse family of phosphoserine- and phosphothreonine-specific enzymes. PP2A consists of three subunits, a catalytic C subunit and a structural A subunit, which form the core enzyme, and a regulatory B subunit that binds to the core enzyme yielding the holoenzyme. The combination of these different subunits gives rise to many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. The PPP2R5D gene at 6p21.1 encodes the 70-kD delta subunit in the B56 family of related PP2A regulatory subunits. Its expression varies with the cell cycle, present in both cytoplasm and nucleus in interphase cells but concentrated in the nucleus of mitotic and recently divided cells. PPP2R5D is highly expressed in the adult brain, and mRNA increases 3- to 5-fold when neuroblastoma cell lines are induced to differentiate by retinoic acid treatment. (from OMIM 601646 and NCI)
C20406	PPP2R5E_Gene	Protein_Phosphatase-2A_Subunit_Gene	PPP2R5E Gene|PPP2R5E	Type 2A protein phosphatase (PP2A) is a diverse family of phosphoserine- and phosphothreonine-specific enzymes. PP2A consists of three subunits, a catalytic C subunit and a structural A subunit, which form the core enzyme, and a regulatory B subunit that binds to the core enzyme yielding the holoenzyme. The combination of these different subunits gives rise to many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. The PPP2R5E gene at chromosome 7p12-p11.2 encodes the 55-kD epsilon subunit in the B56 family of related PP2A regulatory subunits. PPP2R5E is predominantly cytoplasmic, excluded from the nucleus and concentrated in a perinuclear spot of unknown function. There are two isoforms of the PPP2R5E mRNA. (from OMIM 601647 and NCI)
C20407	PPP2R4_Gene	Protein_Phosphatase-2A_Subunit_Gene	PPP2R4 Gene|PPP2R4|PR53|PTPA	Type 2A protein phosphatase (PP2A) is a diverse family of phosphoserine- and phosphothreonine-specific enzymes. PP2A consists of three subunits, a catalytic C subunit and a structural A subunit, which form the core enzyme, and a regulatory B subunit that binds to the core enzyme yielding the holoenzyme. The combination of these different subunits gives rise to many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. The PPP2R4 gene at 9q34 encodes a specific and reversible activator that stimulates phosphotyrosyl phosphatase activity of PP2A core heterodimer in the presence of ATP and Mg(+2). The pPP2R4 gene has a TATA-less promoter that is GC-rich and containing four Sp1 sites. PPP2R4 is widely expressed and four isoforms are produced by alternative slicing. This gene is probably not involved in chronic myeloid leukemia. (From OMIM, LocusLink and NCI)
C20408	VAV_Family_Gene	Signaling_Pathway_Gene	VAV Family Gene	VAV Family Genes (VAV1, VAV2, and VAV3) encode VAV proteins that respond to similar cell surface receptor tyrosine kinases as GEFs for Rho/Rac family GTPases, which activate pathways leading to actin cytoskeletal rearrangements, transcriptional alterations, cell differentiation, and/or cell proliferation. VAV proteins contain CH, DH, PH, SH2, SH3, and zinc-dependent phorbol-ester and DAG binding domains. VAV1 is expressed exclusively in hematopoietic cells, while VAV2 and VAV3 are more broadly expressed. (NCI)
C20409	BCL-2_Gene_Family	Apoptosis_Regulation_Gene	BCL-2 Gene Family	The BCL-2 Gene Family encodes proteins that contain Bcl-2 homology (BH) domains (1, 2, 3, or 4), involved in interactions among apoptotic protein factors that participate in programmed cell death. (NCI)
C20410	BCL2L1_Gene	BCL-2_Gene_Family	BCL2L1 Gene|BCL2-Like 1|BCL2-Related Gene|BCL2L1|BCLX	A BCL2-related gene, designated BCLX.  It can function as a BCL2-independent regulator of programmed cell death (apoptosis). Alternative splicing resulted in 2 distinct BCLX mRNAs. The protein product of the larger mRNA (BCLXL) was similar in size and predicted structure to BCL2.  It inhibits cell death upon growth factor withdrawal at least as well as BCL2 in a transfected IL3-dependent cell line.  On the other hand, the smaller mRNA species (BCLXS) encodes a protein that inhibits the ability of BCL2 to enhance the survival of growth factor-deprived cells.
C20411	BCL2L2_Gene	Apoptosis_Inhibitor_Gene|BCL-2_Gene_Family	BCL2L2 Gene|BCL-W|BCL2 Like 2|BCL2-Like 2 Gene|BCL2L2|BCLW|KIAA0271	This gene encodes a member of the BCL-2 protein family. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. (from RefSeq Summary)
C20412	MCL1_Gene	BCL-2_Gene_Family	MCL1 Gene|EAT|MCL1|Myeloid Cell Leukemia Sequence 1 Gene	Encodes an antiapoptotic Bcl-2 family member that presents in neutrophils
C20413	BAK1_Gene	Apoptosis_Promoter_Gene|BCL-2_Gene_Family	BAK1 Gene|BAK|BAK1|BCL2-Antagonist/Killer 1 Gene|BCL2L7|CDN1|Cell Death Inhibitor 1 Gene	Encodes a BCL2 related protein that induces apoptosis.  May cause the mitochondrial voltage-dependent anion channel to open and release cytochrome c into the cytoplasm resulting in caspase activation. (from RefSeq Summary)
C20414	BAD_Gene	BCL-2_Gene_Family	BAD Gene|BAD|BBC2|BCL2L8	The protein encoded by this gene is a member of the BCL-2 family. It positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. (from RefSeq Summary)
C20415	BCL-Xs_Protein	Apoptosis_Promoter	BCL-Xs Protein|BCL-X Short Isoform|BCL2-Like 1, Short Isoform|BCL2-Related Protein 1, Short Isoform|BCL2L1|Bcl2-Related Protein, Short Isoform|bcl-xS	Bcl-X has two isoforms, Bcl-XL (long) a 241 amino acid protein and Bcl-XS (short) a 178 amino acid protein lacking a 63 amino acid domain that is well conserved among members of the Bcl-2 family.
C20416	BCL2L11_Gene	Apoptosis_Promoter_Gene|BCL-2_Gene_Family	BCL2L11 Gene|BAM|BCL-2-Related Ovarian Death Agonist Gene|BCL2-like 11 (Apoptosis Facilitator) Gene|BCL2L11|BIM|BIMEL|BIML|BOD|BimMEL	The protein encoded by this gene belongs to the BCL-2 protein family. It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests the roles of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of the apoptosis in thymocyte-negative selection. Eight alternatively spliced transcript variants of this gene have been reported. (from RefSeq Summary)
C20417	BIK_Gene	Apoptosis_Promoter_Gene|BCL-2_Gene_Family	BIK Gene|BBC1|BCL2-Interacting Killer Gene|BIK|BIP1|BP4|Bik/Nbk Gene|NBK	The protein encoded by this gene is known to interact with cellular and viral survival-promoting proteins, such as BCL2, BCLXL, Epstein-Barr virus BHRF1, and adenovirus E1B 19-kD in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK. (from RefSeq Summary and OMIM)
C20418	HRK_Gene	BCL-2_Gene_Family	HRK Gene|DP5|HRK|Harakiri	Activator of apoptosis HRK regulates apoptosis through interaction with death-repressor proteins Bcl-2 and Bcl-X(L). The HRK protein lacks significant homology to other BCL2 family members except for an 8-amino acid region that was similar to the BCL2 homology domain-3 (BH3) motif of BIK. HRK interacts with BCL2 and BCLXL via the BH3 domain, but not with the death-promoting BCL2-related proteins BAX, BAK, or BCLXS. HRK localizes to membranes of intracellular organelles in a pattern similar to that previously reported for BCL2 and BCLXL. (from RefSeq Summary)
C20419	BID_Gene	Apoptosis_Promoter_Gene|BCL-2_Gene_Family	BID Gene|BH3 Interacting Domain Death Agonist Gene|BID	BID (BH3 Interacting domain Death agonist) encodes a death agonist that heterodimerizes with either agonists (BAX) or antagonists (BCL2). BID is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. (from RefSeq Summary)
C20420	Transcription_Factor_Gene	Gene	Transcription Factor Gene|General Transcription Factor Gene|Proto-Oncogene, Transcription Factor	Genes that code for transcription factors.
C20421	TAF1_Gene	TBP-Associated_Factor_Gene	TAF1 Gene|BA2R|CCG1|CCGS|Cell Cycle Gene 1|NSCL2|TAF(II)250 Gene|TAF1|TAF1 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 250kDa Gene|TAF2A|TAFII250	Encoding 1872-aa 250-kD nuclear TAF(II)250, the largest subunit of TFIID, 98-kb human TAF1 Gene at Xq13.1 expresses two transcript isoforms: variant 2 lacks codons for 21 internal amino acids. Perhaps phosphorylated by casein kinase II, TAF1 contains an HMG box and two bromodomains with highly charged helical bundles that bind to diacetylated histone H4 tails. Similar to Drosophila TAFII-230 and yeast TAFII-111 and TAF145, TAF1 contains N- and C-terminal Ser/Thr kinase domains that auto- and transphosphorylate the basal TFIIF large subunit. TAF1 possesses acetyl transferase activity, acts as an ubiquitin-conjugating enzyme, binds to core promoter transcription start sites, and interacts with TBP, other TAFs, and transcriptional regulators in TFIID assembly and RNA Pol II transcription initiation. Essential for G1 progression, TAF1 links control of transcription to the cell cycle. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C20422	Mitochondrial_Membrane_Protein	Membrane_Protein	Mitochondrial Membrane Protein	Including many peripheral or integral membrane-associated enzymes and transport proteins, Mitochondrial Membrane Proteins are found associated with the smooth outer coat or the highly invaginated inner membrane (cristae) of the semiautonomous, self-reproducing cytoplasmic organelles that constitute the principal site of oxidative phosphorylation (ATP formation) for cellular energy in eukaryotic cells.
C20423	Helicase	Hydrolase	Helicase|Helicases	Helicases are a class of enzymes that utilize the energy of ATP hydrolysis to promote unwinding of 1.) RNA during transcription, splicing and translation or 2.) duplex DNA during replication or repair by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening.
C20424	Growth_Factor	Protein_Organized_by_Function	Growth Factor|GFAC|Growth Agents|Growth Factors|Growth Factors, Proteins|Mitogen|growth factors	Growth Factors are extracellular signaling molecules (ligands) involved in control of target cell proliferation, cell survival, and cell differentiation. (NCI)
C20425	Epidermal_Growth_Factor	Epidermal_Growth_Factor_Superfamily_Protein	Epidermal Growth Factor|Anthelone U|EGF|Human Urinary Gastric Inhibitor|Urogastrone	Epidermal Growth Factor, encoded by the EGF gene, has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin. The EGF precursor is believed to exist as a membrane-bound molecule that is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. (From LocusLink)
C20426	Fibroblast_Growth_Factor	Heparin_Binding_Growth_Factor	Fibroblast Growth Factor|DNA Synthesis Factor|ECGF|Endothelial Cell Growth Factor|FGF|Fibroblast Growth Regulatory Factor	Peptide isolated from the pituitary gland and from the brain. It is a potent mitogen which stimulates growth of a variety of mesodermal cells including chondrocytes, granulosa, and endothelial cells. The peptide may be active in wound healing and animal limb regeneration.
C20427	Hematopoietic_Growth_Factor	Cytokine	Hematopoietic Growth Factor|Hematopoietic Cytokine	Growth factors which promote the development of blood cells.
C20428	Hepatocyte_Growth_Factor	Growth_Factor	Hepatocyte Growth Factor|HGF|HGF/SF|Hepatopoietin A|Lung Fibroblast-Derived Mitogen|Scatter Factor	Human Hepatocyte Growth Factor is also known as Scatter Factor and Hepatopoeitin A.  HGF is a potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types, including renal tubular epithelial cells, epidermal keratinocytes and melanocytes.  A single chain precursor is cleaved to 70 kD and 30kD chains that are linked by one disulfide bond. Both the single chain and cleaved form are active.
C20429	Erythropoietin	Colony_Stimulating_Factor	Erythropoietin|EPO|Epoetin|Erythrocyte Colony Stimulating Factor|Hematopoietin|erythropoietin	Human erythropoietin is an acidic glycoprotein hormone with a molecular mass of 34 kD. As the prime regulator of red cell production, its major functions are to promote erythroid differentiation and to initiate hemoglobin synthesis.[supplied by OMIM](LocusLink)
C20430	Angiogenin	Angiogenesis_Promoter	Angiogenin|ANG|Angiogenin, ribonuclease, RNase A family, 5	Angiogenin is an exceedingly potent mediator of new blood vessel formation.  Expressed in many cells, angiogenin is a homologue of pancreatic ribonuclease.  The ribonucleolytic active site of Angiogenin is critical for angiogenic activity.  (from OMIM 105850 and NCI)
C20431	Amphiregulin	Epidermal_Growth_Factor_Superfamily_Protein	Amphiregulin|AMR|AR|AREG|CRDGF|Colorectum Cell-Derived Growth Factor|Keratinocyte-Derived Autocrine Factor|MGC13647|SDGF|Schwannoma-Derived Growth Factor	Amphiregulin is a heparin-binding, heparin-inhibited member of the epidermal growth factor family and an autocrine growth factor for human keratinocytes. It seems to play an important role in mammary epithelial cell growth regulation. It shows overexpression in various tumors.  It is encoded by the AREG gene.
C20432	Betacellulin	Epidermal_Growth_Factor_Superfamily_Protein	Betacellulin|BTC|BTC Protein|Beta Cellulin|Beta-Cellulin	Betacellulin is a member of the EGF family of growth factors; a potent mitogen for retinal pigment epithelia and vascular smooth muscle cells. Betacellulin effects may be mediated by the EGF receptor and/or related receptors. The precursor form is a type I membrane protein that contains one EGF-like domain and is synthesized in several tissues and tumor cells. Betacellulin from pancreatic beta cells could play a role in the vascular complications associated with diabetes. (from Swiss-Prot P35070 and NCI)
C20433	Neuregulin	Epidermal_Growth_Factor_Superfamily_Protein	Neuregulin|ARIA|GGF|Glial Growth Factor|Heregulin|NDF|Neu-Differentiation Factor|Sensory-and-motor-derived factor	Neuregulin (heregulin) polypeptides have been shown to interact with and activate the ErbB2, ErbB3 and ErbB4 receptor proteins, and have been found to be essential for the normal development of the cardiovascular, pancreatic and nervous systems. Neuregulins are involved in the normal development of mammary gland, are secreted by breast cancer cells, and can alternatively promote or inhibit breast cancer cell division.
C20434	Fibroblast_Growth_Factor-5	Fibroblast_Growth_Factor	Fibroblast Growth Factor 5|FGF-5|FGF5|HBGF-5	A member of the heparin-binding growth factor family, FGF5 is expressed in neonatal brain.  Two isoforms (long and short) are produced by alternative splicing.  (from OMIM 165190 and NCI)
C20435	Fibroblast_Growth_Factor-6	Fibroblast_Growth_Factor	Fibroblast Growth Factor 6|FGF-6|FGF6|HBGF-6|HST-2	Fibroblast Growth Factor 6 is encoded by the HST2 proto-oncogene and belongs to the heparin-binding growth factor family.  FGF6 exhibits strong mitogenic and angiogenic properties and may be expressed by cells with platelet/megakaryocytic differentiation potential.  (from Swiss-Prot P10767 and NCI)
C20436	Fibroblast_Growth_Factor-7	Fibroblast_Growth_Factor	Fibroblast Growth Factor 7|FGF-7|FGF7|KGF|Keratinocyte Growth Factor	Fibroblast Growth Factor 7 (Keratinocyte Growth Factor) is a member of the fibroblast growth factor family that stimulates the growth of epithelial cells, but lacks mitogenic activity on fibroblasts or endothelial cells.  FGF7 is a single polypeptide chain of about 28 kD that has predominant activity in keratinocytes.  (from OMIM 148180 and NCI)
C20437	Colony_Stimulating_Factor-1	Colony_Stimulating_Factor	Colony Stimulating Factor 1|CSF1|Macrophage Colony Stimulating Factor	Synthesized by mesenchymal cells, Macrophage Colony-Stimulating Factor is a 70 kD disulfide-bonded homodimeric glycoprotein cytokine that binds to FMS (a specific high affinity receptor) and stimulates survival, proliferation, and differentiation of committed hematopoietic cells of the related granulocyte and monocyte-macrophage lineages.  Three isoforms of M-CSF result from alternative splicing.  The active forms may be produced by proteolytic cleavage; precursors may exist as integral membrane proteins.  Isoform 1 may undergo rapid proteolytic cleavage to yield an extracellular growth factor.  Isoform 3 may exist as an integral membrane protein that undergoes slow proteolysis at the cell surface to yield a soluble growth factor.  (from OMIM 120420, SWISS-PROT P09603, and NCI)
C20438	Granulocyte_Colony-Stimulating_Factor	Retired_Concepts	Granulocyte Colony-Stimulating Factor|G CSF|G-CSF|Granulocyte Colony Stimulating Factor
C20439	Interleukin-3	Hematopoietic_Growth_Factor|Interleukin	Interleukin-3|Colony-Stimulating Factor 2 Alpha|Eosinophil-Mast Cell Growth-Factor|Erythrocyte Burst-Promoting Factor|Hematopoietic Growth Factor|IL-3|IL3|IL3 Protein|Interleukin 3|Interleukin 3 (Colony-Stimulating Factor, Multiple)|Interleukin 3 Precursor|MCGF|MULTI-CSF|Mast-Cell Colony-Stimulating Factor|Mast-Cell Growth Factor|Multilineage-Colony-Stimulating Factor|Multipotential Colony-Stimulating Factor|P-Cell Stimulating Factor	Human interleukin-3 (152 aa, 17 kDa precursor) is encoded by the human interleukin-3 (IL3) gene. This protein is a potent growth-promoting cytokine that enhances the ability of the immune system to fight tumor cells. IL-3 supports proliferation of many hematopoietic cell types. It is involved in cell growth, differentiation and apoptosis in addition to possessing neurotrophic activity. Abnormalities in this protein may be associated with neurologic disorders.
C20440	Kit_Ligand	Hematopoietic_Growth_Factor	Kit Ligand|C-Kit Ligand|KITLG|MGF|MGF Stem Cell Factor|Mast Cell Growth Factor|SCF|Steel Factor|Stem Cell Factor	Stem Cell Factor is a hematopoietic growth factor, a key signal in mast cell differentiation and function, and a ligand for the KIT tyrosine kinase receptor CD117.  In the mouse, this growth factor is encoded by Sl ('steel'), a gene critical to the development of several cell lineages as well as to hematopoiesis in the adult.  SCF augments proliferation of myeloid and lymphoid progenitors.  (from OMIM 184745 and NCI)
C20441	Thrombopoietin	Hematopoietic_Growth_Factor	Thrombopoietin|C-MPL Ligand|MGDF|MPL Ligand|Megakaryocyte Colony Stimulating Factor|Megakaryocyte Growth and Development Factor|THPO|TPO|TSF|thrombopoietin	A colony-stimulating factor that stimulates the production of blood cells, especially platelets, during chemotherapy. It is a cytokine that belongs to the family of drugs called hematopoietic (blood forming) agents.
C20442	Insulin-Like_Growth_Factor	Growth_Factor	Insulin-Like Growth Factor|IGF|Somatomedin	Bound to IGFBPs in the circulation, Insulin-Like Growth Factors (IGFs, Somatomedins) are a family of extracellular signaling peptides (potential autocrine ligands) involved in mediation of growth hormone action, stimulation of insulin action, and growth and development. The three main somatomedins are Somatomedin C (IGF1), Somatomedin A (IGF2), and Somatomedin B. Single chain IGFs I and II share about 47% amino acid homology with insulin (INS) and 31% with relaxin.
C20443	Neurotrophin	Retired_Concepts	Neurotrophin|Neurotrophic Factor
C20444	Nerve_Growth_Factor	Neurotrophic_Factor	Nerve Growth Factor|NGF|Nerve Growth Factor 1	Nerve growth factor.  A peptide of 118 amino acids with both chemotropic and chemotrophic properties for sympathetic and sensory neurons.  Found in a variety of peripheral tissues, NGF attracts neurites to the tissues by chemotropism, where they form synapses.  NGF was the first of a family of nerve tropic factors to be discovered.
C20445	Brain-Derived_Neurotrophic_Factor	Nerve_Growth_Factor	Brain-Derived Neurotrophic Factor|BDNF|MGC34632	Brain-Derived Neurotrophic Factor is a member of the nerve growth factor family.  It exerts trophic action on retinal, cholinergic, and dopaminergic neurons in the brain and on motor and sensory neurons in the peripheral nervous system.  Target cells regulate neuronal survival by producing neurotrophic factors, such as NGF and BDNF, which show sequence similarity.  Proforms of NGF and BDNF are secreted and cleaved by plasmin serine protease and matrix metalloproteinases (MMP7, MMP3); proforms preferentially activate p75(NTR) to mediate apoptosis and mature forms activate TRK receptors to promote survival.  Huntingtin up regulates transcription of BDNF.  Mutated Huntingtin decreases production of BDNF leading to neuronal death.  (from OMIM 113505 and NCI)
C20446	Glial_Cell_Line_Derived_Neurotrophic_Factor	Transforming_Growth_Factor-Beta	Glial Cell Line Derived Neurotrophic Factor|GDNF|Glial Cell-Line Derived Neurotrophic Factor	Glial Cell-Line Derived Neurotrophic Factor contains seven conserved cysteine residues spaced similar to the TGF-beta superfamily.  GDNF is processed to a mature secreted form, which occurs as a homodimer that promotes the survival and differentiation of dopaminergic neurons, can rescue motor neurons from programmed cell death, and protects cells from the neurotoxin MPTP.  GDNF is a ligand for the RET gene product.  (from OMIM 600837 and NCI)
C20447	Parathyroid_Hormone-Like_Hormone	Growth_Factor	Parathyroid Hormone-Like Hormone|PTH-Like Protein|PTHrP|Parathyroid Hormone Like Tumor Factor|Parathyroid Hormone-Related Peptide|Parathyroid Hormone-Related Protein	Parathyroid Hormone-Related protein signals through its receptor PTHR1, regulating endochondral bone development and epithelial-mesenchymal interactions.  PTHRP is an anti-proliferative factor that regulates epidermal cell growth.  Because of its structural homology with PTH and binding to the PTH/PTHRP receptor, PTHRP can mimic the action of PTH, but has evolved to regulate local tissue functions, in contrast to the systemic function of parathyroid hormone.  To carry out its diverse biologic roles, PTHRP functions as a poly-hormone that gives rise to several biologically active peptides, each of which presumably has its own receptor.  To broaden its repertoire even further, it appears to have intracrine effects in the nucleus of cells that produce it, in addition to having autocrine, juxtacrine, paracrine, and possibly endocrine effects after secretion.  (from OMIM 168470 and NCI)
C20448	Platelet-Derived_Growth_Factor	Growth_Factor	Platelet-Derived Growth Factor|PDGF	Expressed in platelets, human Platelet-Derived Growth Factor (PDGF/VEGF Family) is a mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released upon wounding to stimulate adjacent cell growth. PDGF can exist as antiparallel disulfide-linked homodimers (PDGFA, PDGFB) or heterodimers (PDGFA/PDGFB) that bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. (NCI)
C20449	Platelet_Derived_Growth_Factor_Beta_Chain	Platelet-Derived_Growth_Factor	Platelet Derived Growth Factor Beta Chain|Becaplermin|PDGF B-Chain|PDGF, B Chain|PDGF-2|PDGFB|Platelet-Derived Growth Factor Beta|Platelet-Derived Growth Factor Beta Polypeptide|Platelet-Derived Growth Factor, B Chain|Platelet-Derived Growth Factor, Beta Polypeptide|SIS Gene Product	Expressed as 2 alternative isoforms in platelets by human PDGFB Gene (PDGF/VEGF Family), 241-aa 27-kDa (precursor) Platelet-Derived Growth Factor-Beta Chain is a potent mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released by platelets upon wounding to stimulate adjacent cell growth. PDGFB can exist as either antiparallel disulfide-linked homodimers or heterodimers with Platelet-Derived Growth Factor Alpha. A-A, B-B, and A-B, dimers can bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. PDGFB mutations are associated with meningioma. Reciprocal t(17;22)(q22;q13) translocations with COL1A1 result in unregulated growth factor expression and are associated with DFSP. (NCI)
C20450	Vascular_Endothelial_Growth_Factor	Angiogenesis_Promoter	Vascular Endothelial Growth Factor|VEGF|VEGF-A|VEGF121|VEGF145|VEGF148|VEGF165|VEGF183|VEGF189|VEGF206|VPF|Vascular Endothelial Growth Factor A|Vascular Permeability Factor	Encoded by human VEGF Gene (PDGF/VEGF Family), widely expressed 232-amino acid 27 kD (precursor) VEGF exhibits seven isoforms: VEGF206, -189, -183, -165/VEGF, -148, -145, and -121. VEGF121 is acidic; VEGF165 is more basic and binds heparin/ECM; VEGF189 is very basic. VEGF is a disulfide-linked, 41-45 kD secreted homodimeric glycoprotein angiogenic growth factor; it may heterodimerize with PLGF. VEGF inhibits apoptosis and promotes endothelial proliferation, cell migration, and vascular permeabilization. VEGF interacts with VEGFR1/FLT-1 and VEGFR2/KDR/FLK1 receptors. VEGF145 may inhibit -165 binding to FLK1. Collapsin/semaphorin receptor Neuropilin-1 (VEGF165R) mediates neuronal cell guidance and binds VEGF165 and -145, but not -121; it enhances VEGF165/KDR binding and chemotaxis.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C20451	Interleukin-6	Interleukin|Neuropoietic_Cytokine	Interleukin-6|B Cell Differentiation Factor 2|B-Cell Differentiation Factor|B-Cell Stimulatory Factor 2|B-Cell Stimulatory Factor-2|BSF-2|BSF2|HGF|HPGF|HSF|Hepatocyte Stimulating Factor|Hybridoma Growth Factor|IFN Beta 2|IFNB2|IL-6|IL6|IL6 Protein|Interferon Beta-2|Interferon, Beta-2|Interleukin 6|Interleukin 6 (Interferon, Beta 2)|Myeloid Differentiation Inducing Protein|Plasmacytoma Growth Factor|Sigosix|interleukin-6	(in-ter-LOO-kin) IL-6. A type of biological response modifier (a substance that can improve the body's natural response to infection and disease). These substances are normally produced by the body, but they can also be made in the laboratory for use in treating cancer and other diseases.
C20452	Pleiotrophin	Heparin-Binding_Neurotrophic_Factor	Pleiotrophin|HBGF-8|HBNF|Heparin-Binding Growth Factor-8|Heparin-Binding Neurotrophic Factor|Neurite Growth-Promoting Factor 1|PTN	A secreted growth factor that is mitogenic for endothelial, epithelial, and fibroblast cells but can also induce neurite outgrowth.  It functions as a growth factor during neonatal brain development, for primate trophoblast formation, and during tumor invasion, angiogenesis, and metastasis.
C20453	Transforming_Growth_Factor	Growth_Factor	Transforming Growth Factor|TGF|Tumor Growth Factors	Transforming Growth Factors are a family of extracellular signaling peptides involved in cell growth stimulation. Found in hematopoietic tissue, various TGF-beta subtypes stimulate wound healing and may inhibit lymphopoiesis and myelopoiesis. TGF-alpha binds to EGFR and stimulates endothelial cell growth.
C20454	Transforming_Growth_Factor_Alpha	Transforming_Growth_Factor	Transforming Growth Factor Alpha|Epidermal Growth Factor Related Transforming Growth Factor|TGF A|TGF-Alpha|TGFA|Transforming Growth Factor, Alpha|Transforming Growth Factor-Alpha	Transforming growth factor alpha (TGFA) stimulates the growth and proliferation of cells, and its overexpression has been correlated with patient survival in a variety of tumors, including squamous carcinoma of the esophagus. In esophageal adenocarcinoma patients who received high-dose radiation and chemotherapy those with tumors that persistently expressed or that increased TGFA expression had a worse prognosis. (from Int J Radiat Oncol Biol Phys. 1995;31:567-9)
C20455	Transforming_Growth_Factor-Beta	Transforming_Growth_Factor	Transforming Growth Factor-Beta|Bone-Derived Transforming Growth Factor|Milk Growth Factor|TGF B|TGF-Beta	Factor synthesized in a wide variety of tissues including platelets, placenta, and both normal and transformed cell lines. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta also has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. There are at least three forms of TGF-beta: TGF-beta1, TGF-beta2, and TGF-beta1.2. The latter is a heterodimer made up of both TGF-beta1 and TGF-beta2. (On-line Medical Dictionary)
C20456	Activin	Protein_or_Riboprotein_Complex	Activin	Disulfide-linked homo- and heterodimeric growth factors (Activin A, Activin B, Activin AB) of the TGF Family with effects on a range of cell types in addition to promoting FSH release in gonadal sites, depending on subunit composition. Composed of Beta-A and Beta-B subunits.
C20457	Transforming_Growth_Factor_Beta-1	Angiogenesis_Inhibitory_Protein|Transforming_Growth_Factor-Beta	Transforming Growth Factor Beta 1|TGF-Beta 1|TGF-Beta1|TGFB1|Transforming Growth Factor-Beta 1	TGFB is a multifunctional peptide cytokine that controls proliferation, differentiation, and other functions in many cell types.  Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor.  SMAD proteins mediate TGFB signaling.  SNON appears to maintain the repressed state of TGFB target genes in the absence of ligand and participates in negative feedback regulation of TGFB signaling. (from OMIM 190180 and NCI)
C20458	Transforming_Growth_Factor_Beta-2	Angiogenesis_Inhibitory_Protein|Transforming_Growth_Factor-Beta	Transforming Growth Factor Beta 2|Cartilage-Inducing Factor-B|Glioblastoma-Derived T-Cell Suppressor Factor|TGF-Beta 2|TGF-Beta2|TGF-b2|TGF-beta-2|TGFB2|Transforming Growth Factor-Beta 2	TGF-beta 2, encoded by the TGFB2 gene, is a disulfide-linked homodimer belonging to the TGF-beta cytokine family that has suppressive effects on Interleukin-2-dependent T-cell growth. It may have an autocrine function in enhancing tumor growth and/or reducing immunosurveillance of tumor development. Two isoforms are produced by alternative splicing. TGF-beta 2 is expressed in a wide variety of mesenchymal tissues and in the ventral nervous system during human embryogenesis. (from OMIM 190220, Swiss-Prot P08112, and NCI)
C20459	Transforming_Growth_Factor_Beta-3	Angiogenesis_Inhibitory_Protein|Transforming_Growth_Factor-Beta	Transforming Growth Factor Beta 3|TGF-Beta 3|TGF-Beta-3|TGFB3|Transforming Growth Factor-Beta 3	Transforming Growth Factor Beta 3, encoded by the TGFB3 gene, is a member of the TGF-beta cytokine family. It is expressed as a disulfide-linked homodimer in a wide variety of mesenchymal tissues during human embryogenesis. Transforming Growth Factor Beta 3 is involved in cell differentiation. (from OMIM, Swiss-Prot and NCI)
C20460	TBP_Gene	B-TFIID_Subunit_Gene|TFIID_Subunit_Gene	TBP Gene|GTF2D|GTF2D1|SCA17|TATA Box Binding Protein Gene|TATA Sequence-Binding Protein Gene|TBP	The TBP gene at 6q27 encodes the TATA box-binding protein (TBP) that is the DNA-binding subunit of the RNA polymerase II transcription factor D (TFIID), a multisubunit complex essential for the expression of most, if not all, protein-encoding genes. The C-terminal domain of TBP is both necessary and sufficient for interaction with DNA and for assembly of the basal transcription apparatus in the initiation of mRNA synthesis and basal transcription. When bound to the TATA box, TBP interacts with the other subunits of TFIID such as TBP-associated factors (TAFs), with TFIIA and TFIIB, with the A form of RNA polymerase II CTD, and with positive and negative modulators of basal and activated transcription of class II genes. The N-terminus of TBP modulates the DNA-binding activity of the C-terminal of the protein. A complex neurologic and polyglutamate disease is due to (CAG)n repeat expansion in the TBP gene. (from OMIM 600075)
C20461	World_Wide_Web	Telecommunications	World Wide Web|WWW	World WIde Web; a computer network consisting of a collection of internet sites that offer text and graphics and sound and animation resources through the hypertext transfer protocol.
C20462	Apoptosis_Regulation_Gene	Gene	Apoptosis Regulation Gene	Apoptosis Regulation Genes encode Apoptosis Regulator proteins, which either promote or impede the initiation, progress, or rate of apoptosis. (NCI)
C20463	TERC_Gene	Telomere_Maintenance_Gene	TERC Gene|TERC|TR|TRC3|Telomerase RNA Component Gene	Telomerase is essential for maintenance of telomere length and genomic integrity in the long-term viability of high-renewal organ systems but is not required for establishment of cell lines, oncogenic transformation, or tumor formation in mice. Telomerase has both a protein and an RNA component. The TERC gene encodes the RNA component that acts as a template for the addition of telomeric repeat sequences. TERC is highly expressed in the germline and in tumor cell lines, in which there is high telomerase activity, and at lower levels in kidney, prostate, and liver, in which there is no detectable telomerase activity. The TERC gene is located at chromosome 3q21-q28 on the long arm of chromosome 3. Autosomal dominant dyskeratosis congenita is associated with mutations in the TERC gene. (from OMIM 602322 and NCI)
C20464	Cytokine	Protein_Organized_by_Function	Cytokine|Cytokines	Cytokines are soluble glycoproteins released by cells of the immune system, which act nonenzymatically through specific receptors to regulate immune responses. Cytokines resemble hormones in that they act at low concentrations and bind with high affinity to a specific receptor. (Health On the Net Allergy Glossary; http://www.hon.ch/Library/Theme/Allergy/Glossary/allergy.html)
C20465	ATL_Derived_Factor	Oxidoreductase	ATL Derived Factor|ADF|ATL Derived Factor/Human Thioredoxin|Adult T Cell Leukemia-Derived Factor|Human Thioredoxin|SASP|Surface Associated Sulphydryl Protein|TXN	ATL Derived Factor (thioredoxin) appears to be a cytokine as well as an oxidoreductase involved in redox reactions through reversible oxidation of its active center dithiol to a disulfide, catalyzing dithiol-disulfide exchange reactions.  It is ubiquitous, found in many organisms from plants and bacteria to mammals, and appears to have multiple substrates, including ribonuclease, choriogonadotropins, coagulation factors, glucocorticoid receptor, and insulin.  ATL Derived Factor augments expression of the IL2R, TAC (IL2R/P55).  (from OMIM 187700, Swiss-Prot P10599, and NCI)
C20466	Chemokine	Cytokine	Chemokine|Chemokines|Chemotactic Cytokines|Homologous Chemotactic Cytokines|Intercrines|SIS cytokines	Chemokines constitute a superfamily of small (8-10 kDa), inducible, secreted, pro-inflammatory cytokines that are involved in a variety of immune and inflammatory responses as well as in viral infection.  Chemokines act primarily as chemoattractants and activators of specific types of leukocytes.  Some members of this family were initially identified on the basis of their biological activities (e.g., IL-8, GRO), others were discovered using subtractive hybridization (e.g., RANTES) or signal sequence trap (e.g., PBSF/SDF-1)11 cloning strategies.  They attract and activate leukocytes and regulate diverse cellular systems and organs ranging from blood vessels to the central nervous system.
C20467	Alpha_Chemokine	Chemokine	Alpha Chemokine|4q Chemokine|C-X-C Chemokine|CXC Chemokine|Chemokine, CXC	Members of the Alpha-Chemokines are referred to also as the 4q chemokine family because the genes encoding members of this family map to human chromosome 4q12-21. The first two cysteine residues of members of this family are separated by a single amino acids and these proteins, therefore, are called also CXC-Chemokines. Some members of the subgroup of the human CXC-Chemokines are defined by the conserved ELR sequence motif (glutamic acid-leucine-arginine) immediately preceding the first cysteine residue near the amino-terminal end. Chemokines with an ELR sequence motif have been found to chemoattract and activate primarily neutrophils. Chemokines without the ELR sequence motif appear to chemoattract and activate monocytes, dendritic cells, T-cells, NK-cells, B-lymphocytes, basophils, and eosinophils. (from http://www.copewithcytokines.de)
C20468	Beta_Thromboglobulin	Alpha_Chemokine	Beta Thromboglobulin|Beta TG|Beta-TG|CXC Chemokine Ligand 7|NAP-2|PPBP|bTG	Encoded by human PPBP Gene (Alpha Chemokine CXC Family), secreted 128-aa 14-kDa (precursor) Pro-Platelet Basic Protein is a platelet-derived growth factor that is processed to PBP and CTAP-III. Upon platelet activation, PBP is proteolytically converted to Beta Thromboglobulin, a homotetramer released when platelets aggregate. Proteolytic removal of PPBP residues 1-9 produces active peptide CTAP-III/LA-PF4, which stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan, as well as formation and secretion of plasminogen activator. CTAP-III is also proteolytically converted to NAP2, a potent chemoattractant and activator of neutrophils. (NCI)
C20469	Connective-Tissue-Activating_Peptide-III	Alpha_Chemokine	Connective-Tissue-Activating Peptide III|CTAP III|CTAP-III|PPBP	Encoded by human PPBP Gene (Alpha Chemokine CXC Family), secreted 128-aa 14-kDa (precursor) Pro-Platelet Basic Protein is a platelet-derived growth factor that is processed to PBP and Connective-Tissue-Activating_Peptide-III. Proteolytic removal of PPBP residues 1-9 produces active peptide CTAP-III/LA-PF4, which stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan, as well as formation and secretion of plasminogen activator. Upon platelet activation, PBP is proteolytically converted to beta thromboglobulin, a homotetramer released when platelets aggregate; CTAP-III is proteolytically converted to NAP2, a potent chemoattractant and activator of neutrophils. (NCI)
C20470	Epithelial_Neutrophil_Activating_Peptide-78	Alpha_Chemokine	Epithelial Neutrophil Activating Peptide 78|CXCL5|Chemokine (C-X-C motif) Ligand 5|ENA-78|LIX|Lipopolysaccharide-induced CXC Chemokine|Small Inducible Cytokine B5	A 78 amino acid member of the CXC family of chemokines produced and secreted upon stimulation by interleukin 1 (IL1B) or tumor necrosis factor alpha.  Stimulates chemotactic migration of neutrophils, monocytes, lymphocytes, and fibroblasts.
C20471	C-X-C_Motif_Chemokine_Ligand-1	Alpha_Chemokine	Chemokine (C-X-C Motif) Ligand 1|CXC Chemokine Ligand 1|CXCL1|GRO|GRO Protein, Alpha|GRO1 Protein|GROA Protein|MGSA|MGSA, Alpha|Melanoma Growth Stimulating Activity, Alpha|NAP-3|Neutrophil Activating Protein 3	A CXC (or alpha) chemokine also known as MGSA, or melanoma growth-stimulating activity.  This family of chemokines also includes IL-8, platelet factor 4 (PF-4), beta-thromboglobulin (b-TG), IP-10, and ENA-78.  GRO is chemotactic for neutrophils.
C20472	Interferon-alpha_Inducible_Protein_10	Retired_Concepts	Interferon-alpha Inducible Protein 10|IFN-Gamma-Inducible Protein-10|IP-10|NEX348	A member of the alpha-chemokine family, IP10 is secreted from macrophages, endothelial cells, and keratinocytes in response to IFN-gamma and activates a G protein coupled receptor.  IP10 has homology to PFIV, BTG, CTAP-III, and peptides associated with cell proliferation, is a potent inhibitor of angiogenesis, inhibits bone marrow colony formation, has anti-tumor activity, is a chemoattractant for monocytes and T-cells, promotes T-cell adhesion to endothelial cells, and probably participates in chronic cell-mediated inflammatory reactions.  The IP10 gene is a RAS signaling target.  (from OMIM 147310 and NCI)
C20473	Interleukin-8	Alpha_Chemokine|Interleukin	Interleukin-8|Anionic Neutrophil Activating Peptide|Anionic Neutrophil-Activating Peptide|GCP-IL-8|Granulocyte Chemotactic Peptide Interleukin 8|IL-8|IL8|Interleukin 8|Leukocyte Adhesion Inhibitor|MDNCF|Macrophage-Derived Chemotactic Factor|Monocyte-Derived Neutrophil Chemotactic Factor|Monocyte-Derived Neutrophil-Activating Peptide|NAP-1|Neutrophil Activation Factor|Neutrophil Activation Peptide|Neutrophil Chemotactic Factor	A member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types including monocytes, macrophages, T-lymphocytes, fibroblasts, endothelial cells, and keratinocytes. It functions as a chemoattractant, and is also a potent angiogenic factor. (from LocusLink)
C20474	Macrophage_Inflammatory_Protein-2_Alpha	Alpha_Chemokine	Macrophage Inflammatory Protein 2, Alpha|CXCL2|Chemokine (C-X-C motif) Ligand 2|GRO Protein, Beta|GRO2|GRO2 Protein|GROB Protein|MIP2A Protein	Chemokines are small, mostly basic, related molecules that regulate trafficking of leukocytes through interactions with GPCRs.  In response to endotoxin, macrophages secrete MIP2, a protein with affinity for heparin and a potent chemotactic agent for polymorphonuclear leukocytes that causes a localized inflammatory reaction.  (from OMIM 139110 and NCI)
C20475	Macrophage_Inflammatory_Protein-2_Beta	Alpha_Chemokine	Macrophage Inflammatory Protein 2, Beta|CXCL3|GRO Protein, Gamma|GRO3 Protein|GROG Protein|MIP2B Protein	Chemokines are small, mostly basic, related molecules that regulate trafficking of leukocytes through interactions with GPCRs.  There are two protein components of MIP1, alpha and beta.  MIP-2 beta may play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion.  MIP-2 beta expression studies indicate tissue-specific regulation as well as by specific agents, including IL-1, TNF, and lipopolysaccharide.  (from OMIM 139111, Swiss-Prot P19876, and NCI)
C20476	Beta_Chemokine	Chemokine	Beta Chemokine|C-C Chemokine|CC Chemokine|Chemokine, CC	Encoded by CC Cytokine Genes, Beta Chemokines are CC-type dual-cysteine chemokines with adjacent cysteine residues in their primary sequence that act as chemoattractants for lymphocytes, monocytes, eosinophils, and basophils, but not for neutrophils. (NCI)
C20477	C-C_Motif_Chemokine_Ligand-4	Beta_Chemokine	Chemokine (C-C Motif) Ligand 4|ACT2|AT744.1|Act-2|CCL4|Human Macrophage Inflammatory Protein-1 Beta|LAG1|MIP-1 Beta|MIP1B|SCYA4|Small Inducible Cytokine A4	MIP-1 beta chemokine is chemotactic for neutrophils and monocytes, stimulates macrophages, and may play a role in regulating hematopoiesis.  MIP-1 beta is induced rapidly after T-cell activation with phytohemagglutinin, B-cell activation with Staphylococcus aureus, and monocyte activation with lipopolysaccharide.  It is predominantly synthesized by perforin-low memory CD8+ T-cells, a major non-cytotoxic population of CD8+ T-cells.  (from OMIM 182284 and NCI)
C20478	Small_Inducible_Cytokine-A1	Beta_Chemokine	Small Inducible Cytokine A1|CCL1|I-309|I-309 Protein|Inflammatory Cytokine I-309|T Lymphocyte-Secreted Protein I-309	A CCR8-ligand, the inflammatory CXC cytokine I-309 is a small inducible chemotactic factor produced by activated T-lymphocytes, mast cells, and monocytes that appears to also promote angiogenesis.  (from OMIM 182281 and NCI)
C20479	Small_Inducible_Cytokine-A8	Beta_Chemokine	Small Inducible Cytokine A8|CCL8|HC14|MCP-2|Monocyte Chemoattractant Protein-2|SCYA10|SCYA8	Chemokines, a family of small cytokines, attract leukocytes and possess various immunomodulating functions.  CC chemokines influence mononuclear cell types.  Human Macrophage Chemoattractant Protein-2 is a chemotactic factor for monocytes, lymphocytes, basophils and eosinophils.  This monomer or homodimer can bind heparin.  Its expression is induced by interferon gamma, mitogens, and IL-1. (from OMIM 602283, Swiss-Prot P80075, and NCI)
C20480	Cellular_Process	Biological_Process	Cellular Process|Cell Function|Cell Process|Cellular Function	A coordinated, single-cell function or a process involving or requiring whole cells or involving a major or a substantial portion of a cell or of the total machinery of a cell. (NCI)
C20481	Small_Inducible_Cytokine-A3	Beta_Chemokine	Small Inducible Cytokine A3|CCL3|Chemokine (C-C motif) Ligand 3|LD78|MIP-1 Alpha|MIP-1a|Stem Cell Inhibitor	Macrophage Inflammatory Protein-1 is a monokine involved in the acute inflammatory recruitment and activation of polymorphonuclear leukocytes.  There are two protein components of MIP1, alpha and beta. MIP-1 alpha has been identified as an early G0/G1 switch gene in blood mononuclear cells.  RANTES, MIP-1 alpha, and MIP-1 beta are major HIV-suppressive factors produced by CD8-positive T-cells.  (from OMIM 182283 and NCI)
C20482	Monocyte_Chemoattractant_Protein-1	Retired_Concepts	Monocyte Chemoattractant Protein-1
C20483	Small_Inducible_Cytokine-A5	Beta_Chemokine	Small Inducible Cytokine A5|CCL5|Chemokine (C-C Motif) Ligand 5|D17S136E|MGC17164|RANTES|SCYA5|SIS-delta|SISd|T-Cell RANTES Protein|T-Cell Specific Protein p288|TCP228	A member of the interleukin-8 superfamily of cytokines, RANTES is released from platelets and activated T-cells, and is a selective chemoattractant for eosinophils, monocytes, and memory T-lymphocytes.  RANTES expression is increased more than ten-fold in peripheral lymphocytes following mitogenic or antigenic stimulation.  RANTES is one of the natural ligands for the chemokine receptor CCR5.  Chemokines RANTES, MIP-1 alpha, and MIP-1 beta are major HIV-suppressive factors produced by CD8-positive T-cells.  (from OMIM 187011 and NCI)
C20484	Small_Inducible_Cytokine-A21	Beta_Chemokine	Small Inducible Cytokine A21|CCL21|Secondary Lymphoid Tissue Chemokine	Secondary Lymphoid Tissue Chemokine is an endothelial CC (beta) subfamily chemokine expressed preferentially in lymph node tissue.  Unlike other CC chemokines, SLC is specifically chemotactic for Th1 lymphocytes, and for dendritic cells.  The ability of SLC to chemoattract both Th1 lymphocytes and dendritic cells formed the rationale to evaluate this chemokine in cancer immunotherapy.  (from OMIM 602737 and NCI)
C20485	Small_Inducible_Cytokine-A11	Beta_Chemokine	Small Inducible Cytokine A11|CCL11|Eosinophil Chemotactic Protein|Eotaxin	Chemoattractant cytokines (chemokines) are important for leukocyte recruitment to inflammatory lesions.  The eotaxin chemokine is a potent chemoattractant for eosinophil migration and accumulation.  A high-affinity eotaxin receptor CCR3, involved in allergic inflammation, is highly expressed on eosinophils, basophils, and TH2 lymphocytes.  CCR3, a GPCR, induces a calcium response in eosinophils, and also binds RANTES and monocyte chemotactic protein-3.  Eotaxin also interacts with CCR2 and CCR5 receptors and thus can affect monocyte responses.  In monocytes, eotaxin modifies responsiveness to the CCR2 ligand MCP1, as well as to RANTES and MIP1-beta, which bind to CCR5; eotaxin is a CCR5 agonist and a CCR2 antagonist.  Eotaxin also induces endothelial cell migration and angiogenesis.  (from OMIM 601156 and NCI)
C20486	Unclassified_Chemokine	Chemokine	Chemokine, Other	Chemokines (chemotactic cytokines) other than those in the C, CC, or CXC classes.
C20487	C5a	Unclassified_Chemokine	C5a	Smaller fragment formed when C5 convertase splits C5 into C5a and C5b. C5a is a 74-amino acid peptide that includes a carboxy-terminal arginine crucial for its spasmogenic activity and a carbohydrate moiety. Initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex.  C5a is the most potent anaphylatoxin, mediating immediate hypersensitivity. C5a is also chemotactic for neutrophils and monocytes.
C20488	Delta_Chemokine	Chemokine	Delta Chemokine|CX3C Chemokine	The last family member of chemokines is the CX3C (delta) chemokines. As the acronym suggests, there are three amino acids between the N-terminal cysteine residues.
C20489	Small_Inducible_Cytokine-D1	Delta_Chemokine	Small Inducible Cytokine D1|CX3CL1|Chemokine (C-X3-C Motif) Ligand 1|Fractalkine|Neurotactin	Fractalkine, encoded by the cytokine D1 gene, is the first member of a fourth branch of the chemokine superfamily. Unlike other known chemokines, fractalkine is a type 1 membrane protein with a signal peptide, a chemokine domain, a stalk region containing 17 degenerate mucin-like repeats, a transmembrane segment and a cytoplasmic domain. The extracellular domain of fractalkine is released into the supernatants of transfected cells as a 95 kDa glycoprotein, possibly by proteolysis at the dibasic cleavage site proximal to the membrane, to generate soluble fractalkine. mRNA expression is most abundant in the brain and heart, but is also present at lower levels in other tissues tested except peripheral blood where most chemokines are highly expressed. The expression of fractalkine in microglia, endothelial and fibroblastic cells is upregulated by inflammatory signals.
C20490	Gamma_Chemokine	Chemokine	Gamma Chemokine|C Chemokine|Chemokine, C|gamma-Chemokine	Gamma chemokines are cytokines that lack adjacent cysteine residues and act as chemoattractants for lymphocytes. Most members of the chemokind family have at least four conserved cysteine residues that form two intramolecular disulfide bonds.
C20491	Molecular_Nanotechnology	Nanotechnology	Molecular Nanotechnology	Molecular nanotechnology is the name given to a specific sort of manufacturing technology. As its name implies, molecular nanotechnology will be achieved when we are able to build things from the atom up, and we will be able to rearrange matter with atomic precision. This technology does not yet exist; but once it does, we should have a thorough and inexpensive system for controlling of the structure of matter.
C20492	FLT3_Ligand	Hematopoietic_Growth_Factor	FLT3 Ligand|FLT 3 Ligand|FLT3LG|FMS-Related Tyrosine Kinase-3 Ligand	Flt3 ligand is a novel hematopoietic growth factor ligand for the FLT3 tyrosine kinase receptor.  This growth factor stimulates the proliferation of hematopoietic progenitor cells.  FLT3 (FLK2) is a tyrosine kinase receptor structurally related to CSF1 and KIT.  (from OMIM 600007 and NCI)
C20493	Interferon	Cytokine	Interferon|Human Fibroblast Interferon|Human Leukocyte Interferon|Human Lymphoblastoid Interferon|IFN|interferon	Human interferons have been classified into 3 groups: alpha, beta, and gamma. Both alpha- and beta-IFNs, previously designated type I, are acid-stable, but they differ immunologically and in regard to some biologic and physiochemical properties. The IFNs produced by virus-stimulated leukocytes (leukocyte IFNs) are predominantly of the alpha type. Those produced by lymphoblastoid cells are about 90% alpha and 10% beta. Induced fibroblasts produce mainly or exclusively the beta type. The alpha- and beta-IFNs differ widely in amino acid sequence. The gamma or immune IFNs, which are produced by T lymphocytes in response to mitogens or to antigens to which they are sensitized, are acid-labile and serologically distinct from alpha- and beta-IFNs. (from OMIM 147570)
C20494	Interferon_Alpha	Interferon	Interferon Alpha|G-interferon|Ginterferon|Human leukocyte interferon|IFN Alpha|Interferon Alfa-N3|alfa-n3 interferon|alpha interferon|leukocyte interferon|lymphoblast interferon|lymphoblastoid interferon	A class of interferon (leukocyte interferon) produced predominantly by B lymphocytes.  Located in a cluster on 9p22 there are at least 13 functional genes and 1 pseudogene.
C20495	Interferon_Beta	Interferon	Interferon Beta|Beta Interferon|Beta-Interferon|Endogenous Interferon Beta|Fibroblast Interferon|IFN-Beta|Interferon Beta, Natural|Interferon, Beta|Natural human interferon beta	A class of interferon elaborated by fibroblasts.
C20496	Interferon_Gamma	Interferon	Interferon Gamma|Gamma Interferon|Gamma-Interferon|IFN-g|IFNG|Immune Interferon|interferon, gamma|lFN-Gamma|type II interferon	Interferon gamma (IFNg) is produced by activated T cells and is an important immunoregulatory molecule, particularly in allergic diseases.
C20497	Interleukin	Cytokine	Interleukin|Interleukins|interleukins	(in-ter-LOO-kins) Biological response modifiers (substances that can improve the body's natural response to infection and disease) that help the immune system fight infection and cancer. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases.
C20498	Lymphokine	Cytokine	Lymphokine|Lymphokines	A general term for soluble mediators of immune responses that are not antibodies or complement components and that are released by sensitized lymphocytes on contact with antigen.
C20499	Oncostatin-M	Cytokine	Oncostatin M|OSM	A member of the cytokine family that regulates the proliferation and differentiation of a variety of cell types.  This family of proteins adopts a four-helix bundle fold with up-up-down-down topology and contains intramolecular disulfide bonds.  (DCB-CB, OMIM 165095, and NCI)
C20500	Tumor_Necrosis_Factor_Family_Protein	Cytokine	Tumor Necrosis Factor Family Protein|Tumor Necrosis Factors	(TOO-mer ne-KRO-sis) A type of biological response modifier that can improve the body's natural response to disease. (NCI-GLOSS)
C20501	TAF2_Gene	TBP-Associated_Factor_Gene	TAF2 Gene|CIF150|TAF2|TAF2 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 150kDa Gene|TAF2B|TAFII150	The protein that coordinates transcription initiation by RNA polymerase II is transcription factor IID (TFIID). TFIID binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and TBP-associated factors (TAFs). TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. The TAF2 gene at 8q24.12 encodes a 150-kD protein and one of the larger subunits of TFIID that is stably associated with the TFIID complex. It contributes to interactions at and downstream of the transcription initiation site, interactions that help determine transcription complex response to activators. (LocusLink 6873 and NCI)
C20502	TAF3_Gene	TBP-Associated_Factor_Gene	TAF3 Gene|TAF3|TAF3 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 140kDa Gene|TAFII140	The highly conserved RNA polymerase II transcription factor TFIID comprises the TATA box-binding protein and a set of TBP-associated factors (TAFs). TAFs contribute to promoter recognition and selectivity and act as antiapoptotic factors. The TAF3 gene encodes a 140-kD protein that forms complexes with TBP and TAF13 as well as with SF3B3, TAFII140 and GCN5. TAF3 interacts with TAF10 through their HFDs. The TAF3 gene is located at chromosome 10p15.1 on the short arm of chromosome 10. (from OMIM 606576 and NCI)
C20503	TAF4_Gene	TBP-Associated_Factor_Gene	TAF4 Gene|TAF2C|TAF2C1|TAF4|TAF4 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 135kDa Gene|TAF4A|TAFII130|TAFII135	The TAF4 gene at chromosome 20q13.33 encodes a 135-kD protein and one of the larger subunits of TFIID that potentiates transcriptional activation by retinoic acid, thyroid hormone and vitamin D3 receptors.  In addition, this subunit interacts with the transcription factor CREB, which has a glutamine-rich activation domain, and binds to other proteins containing glutamine-rich regions.  TAF4 is sufficient to recruit a polymerase complex and activate basal transcription mediated by CREB.  Increased levels of TAF4 facilitate the induction of a large number of neuronal genes.  Interference of CREB-dependent transcription by the binding of TAF4 with expanded polyQ stretches is involved in the pathogenetic mechanisms underlying neurodegeneration.  At least 8 neurodegenerative disorders, which include Huntington disease and several forms of spinocerebellar ataxia, are due to expansions of CAG repeats encoding polyglutamine (polyQ) stretches.  (NCI)
C20504	Cell_Maintenance	Cell_Viability_Process	Cell Maintenance|Cell Growth and Maintenance	Processes that promote, sustain, and preserve cell viability. (NCI)
C20505	TAF5_Gene	TBP-Associated_Factor_Gene	TAF5 Gene|TAF2D|TAF5|TAF5 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 100kDa Gene|TAFII100	The multisubunit TFIID transcription factor is the DNA-binding component of the transcriptional machinery of RNA polymerase II. TFIID is composed of TATA box-binding protein (TBP) and TBP-associated factors (TAFs). The TAF5 gene encodes a 100-kD protein that is the third largest human TFIID subunit. TAF5 interacts strongly with the histone H4-related TAF6 and the histone H3-related TAF9, as well as a stable complex comprised of both TAF6 and TAF9. Weaker interactions of TAF5 with TBP, TAF1, TAF11, and TAF12, but not TAF7, also occur. TAF5 may stabilize interactions of TAFs, especially the histone-like TAFs, in TFIID for a possible core promoter-specific function. The TAF5 gene is located at chromosome 10q24-q25.2 on the long arm of chromosome 10. (from OMIM 601787, PMID 9045704)
C20506	Interleukin-1	Interleukin	Interleukin-1|IL-1|IL1|IL1B|Lymphocyte Activating Factor|Lymphocyte-Stimulating Hormone|Macrophage Cell Factor	Human interleukin-1 protein (271 aa, 31 kD precursor) is encoded by the human interleukin-1 (IL1) gene. This soluble protein is produced primarily by monocytes and macrophages. It activates and potentiates T-lymphocyte responses to mitogens or antigens. This protein is also capable of replacing macrophage requirements for T-cell activation
C20507	Interleukin-2	Interleukin	Interleukin-2|ETAF|Epidermal Thymocyte Activating Factor|IL-2|IL2|IL2 Protein|Interleukin 2|Interleukin 2 Precursor|Interleukin II|Lymphocyte Mitogenic Factor|Mitogenic Factor|Ro-236019|T Cell Growth Factor|T-Cell Growth Factor|TCGF|TSF|Thymocyte Stimulating Factor	Encoded by human IL2 Gene, Interleukin-2 is a secreted cytokine important for proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). IL2 expression in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling expression of a single gene. Targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role in the immune response to antigenic stimuli. (From LocusLink)
C20508	Interleukin-4	Interleukin	Interleukin-4|B Cell Proliferating Factor|B-Cell Differentiation Factor-1|B-Cell Growth Factor|B-Cell Growth Factor-1|B-Cell Stimulating Factor|B-Cell Stimulation Factor-1|B-Cell Stimulatory Factor 1|BCDF-1|BCGF|BCGF-1|BCSF 1|BSF-1|BSF1|IL-4|IL4|IL4 Protein|Interleukin 4|Interleukin-4 Precursor|Lymphocyte Stimulatory Factor 1|MCGF 2|Mast Cell Growth Factor-2|T-Cell Growth Factor 2	(in-ter-LOO-kin) IL-4. A type of biological response modifier (a substance that can improve the body's natural response to infection and disease) that enhances the immune system's ability to fight tumor cells. These substances are normally produced by the body. They are also made in the laboratory for use in treating cancer and other diseases.
C20509	Interleukin-5	Hematopoietic_Growth_Factor|Interleukin	Interleukin-5|B Cell Differentiation Factor I|B-Cell Growth Factor-II|BCGF-II|EDF|Eo-CSF|Eosinophil Differentiation Factor|IL-5|IL5|Interleukin 5|Interleukin 5 (Colony-Stimulating Factor, Eosinophil)|Interleukin 5 Precursor|T-Cell Replacing Factor|TRF	Human interleukin-5 protein (134 aa, 15 kDa precursor) is encoded by the human interleukin-5 (IL5) gene. This cytokine acts as a growth and differentiation factor for eosinophils and induces terminal differentiation of B-cells which become Ig-secreting cells. It is thought to play a pivotal role in the pathogenesis of asthma. Elevated levels of this protein have been detected in both asthma and hypereosinophilic syndromes.
C20510	Interleukin-7	Interleukin	Interleukin-7|IL-7|IL7|IL7 Protein|Interleukin 7 Precursor|Lymphopoietin-1	Encoded by human IL7 Gene, Interleukin-7 is an important cytokine for B and T cell development. This cytokine and HGF form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. IL7 is a cofactor for V(D)J rearrangement of T cell receptor beta (TCRB) during early T cell development. IL7 can be produced locally by intestinal epithelial and epithelial goblet cells, and may be a regulatory factor for intestinal mucosal lymphocytes. Studies in mice suggest that IL7 plays an essential role in lymphoid cell survival. (From LocusLink)
C20511	Interleukin-9	Interleukin	Interleukin-9|HP40|Homolog of Mouse T Cell and Mast Cell Growth Factor 40|IL-9|IL9|IL9 Protein|Interleukin 9|Interleukin 9 Precursor|P40 T-Cell Growth Factor|P40 T-Cell and Mast Cell Growth Factor|T-Cell Growth Factor p40|T-Cell/Mast Cell Growth Factor p40|p40|p40 Cytokine|p40 Protein	Human interleukin-9 protein (144 aa 16 kDa precursor) is encoded by the human interleukin-9 (IL9) gene. This glycoprotein is secreted by T-cells and macrophages. It is a cytokine growth factor that activates STAT proteins through IL-9R and may serve as a regulator of both lymphoid and myeloid systems.
C20512	Interleukin-10	Interleukin	Interleukin-10|CSIF|CSIF-10|Cytokine Synthesis Inhibitory Factor|IL-10|IL10|IL10A|Interleukin 10|Interleukin 10 Precursor|TGIF	Expressed primarily in monocytes and less in lymphocytes by human IL10 Gene, Interleukin-10 is a cytokine with pleiotropic effects in immunoregulation and inflammation. It down-regulates expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Studies in mice suggest that this cytokine as an essential immunoregulator in the intestinal tract. (From LocusLink)
C20513	Interleukin-11	Interleukin	Interleukin-11|Adipogenesis Inhibitory Factor|IL-11|IL11|Interleukin 11	Human interleukin-11 protein (199 aa, 21 kDa precursor) is encoded by the human interleukin-11 (IL11) gene. This protein stimulates T-cell-dependent development of immunoglobulin-producing B cells in antigen-specific antibody responses. It supports proliferation of both hematopoietic stem cells and megakaryocyte progenitor cells and regulates bone marrow adipogenesis. This protein also plays immunomodulatory roles in rheumatoid arthritis.
C20514	Interleukin-12	Protein_or_Riboprotein_Complex	Interleukin-12|CLMF|Cytotoxic Lymphocyte Maturation Factor|IL-12|IL12|Interleukin 12|NKSF|Natural Killer Cell Stimulatory Factor	Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI)
C20515	Interleukin-13	Interleukin	Interleukin-13|IL-13|IL13|Interleukin 13	Interleukin-13, encoded by the IL13 gene, is an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. Interleukin-13 is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. (From LocusLink)
C20516	Interleukin-14	Interleukin	Interleukin-14|HMW-BCGF|High Molecular Weight B-Cell Growth Factor|High Molecular Weight-B-Cell Growth Factor|Hypothetical Protein Initially Thought to Be Identical With Interleukin-14|IL-14|IL14|Interleukin 14	Interleukin-14, encoded by the IL14 gene, is a cytokine that induces B-cell proliferation, inhibits immunoglobulin secretion, and selectively expands certain B-cell subpopulations. (from The On-line Medical Dictionary http://cancerweb.ncl.ac.uk/omd/)
C20517	Interleukin-15	Interleukin	Interleukin-15|IL-15|IL15|IL15 Protein|Interleukin 15|Interleukin-15 Precursor|MGC9721	Interleukin-15, encoded by the IL15 gene, is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukin 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Three alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. (From LocusLink)
C20518	Interleukin-16	Interleukin	Interleukin-16|IL-16|IL16|IL16 Protein|Interleukin 16|LCF|Lymphocyte Chemoattractant Factor|prIL-16	Interleukin-16, encoded by the IL16 gene, is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. As a ligand for CD4, the signaling process of this cytokine is mediated by CD4. It stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils as well as induces T-lymphocyte expression of interleukin 2 receptor. The product of this gene undergoes proteolytic processing, which yields two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is involved in the proteolytic processing of this protein. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. (From LocusLink, Swiss-Prot and NCI)
C20519	Interleukin-17	Interleukin	Interleukin-17|CTLA-8|CTLA8|Cytotoxic T-Lymphocyte-Associated Antigen 8|Cytotoxic T-Lymphocyte-Associated Serine Esterase 8|IL-17|IL-17A|IL17|IL17 Protein|IL17A|Interleukin 17|Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)|Interleukin 17 Precursor	Interleukin 17 is a homodimer expressed in stimulated, but not resting, cytotoxic T-cells that induces stromal cells to produce pro-inflammatory and hematopoietic cytokines.  IL17 enhances expression of IL6, IL8, and ICAM-1 in fibroblasts and appears to induce osteoclastogenesis and ODF, a membrane-associated protein essential to osteoclast differentiation.  IL17 has sequence similarity to the herpesvirus saimiri immediate early gene 13 protein.  (from OMIM 603149 and NCI)
C20520	Interleukin-18	Interleukin	Interleukin-18|IFN-gamma-Inducing Factor|IGIF|IL-1 Gamma|IL-18|IL-1g|IL18|IL18 Protein|IL1F4|Interferon-Gamma Inducing Factor|Interferon-Gamma-Inducing Factor|Interleukin 18|Interleukin 18 (Interferon-Gamma-Inducing Factor)|Interleukin 18 Proprotein|Interleukin-1 Gamma|Interleukin-18 Precursor|MGC12320	Cytokine which resembles IL-1 structurally and IL-12 functionally. It enhances the cytotoxic activity of NK cells and CTLs, and appears to play a role both as neuroimmunomodulator and in the induction of mucosal immunity.
C20521	Interleukin-1-Alpha	Interleukin-1	Interleukin-1-Alpha|Hematopoietin-1|IL-1-a|IL-1A|IL-1alpha|IL1|IL1-Alpha|IL1A|IL1A Protein|IL1F1|Interleukin 1, Alpha|Interleukin 1-Alpha|Preinterleukin 1 Alpha	IL-1-alpha. A type of biological response modifier (a substance that can improve the body's natural response to infection and disease). IL-1-alpha stimulates the growth and action of immune system cells that fight disease. IL-1-alpha is normally produced by the body, but it can also be made in the laboratory.  Also called IL-1-alfa.
C20522	Interleukin-1-Beta	Interleukin-1	Interleukin-1-Beta|Catabolin|IL-1|IL-1-b|IL1-Beta|IL1B|IL1B Protein|IL1F2|Interleukin 1|Interleukin 1, Beta|Interleukin 1, Beta Proprotein|Interleukin 1-Beta|Preinterleukin 1 Beta	Interleukin-1 (endogenous pyrogen), produced primarily by monocytes, is an important pro-inflammatory cytokine that mediates the acute phase host response.  The biologic activities of IL1 are properties of a protein derived from a larger precursor.  Inflammation causes induction of COX2, leading to release of prostanoids, which sensitize peripheral nociceptor terminals and produce local pain hypersensitivity.  Inflammation also generates sensitivity in neighboring tissue, muscle and joint pain, fever, lethargy, and anorexia.  COX2 induction in regions of the CNS is mediated by IL1B.  Interleukin-1-beta also stimulates bone resorption.  IL1RN is a competitive inhibitor of IL1B.  Mature IL1-beta levels are a sensitive and specific indicator of caspase-1 activation.  (from OMIM 147720 and NCI)
C20523	Leukocyte_Interleukin	Retired_Concepts	Leukocyte Interleukin|Buffy coat interleukins|Multikine
C20524	Leukemia_Inhibitory_Factor	Cytokine	Leukemia Inhibitory Factor|Cholinergic Differentiation Factor|D Factor|D-Factor|Differentiation Stimulating Factor|Differentiation-Stimulating Factor|Human Interleukin in DA Cells|LIF|Leukemia-Inhibitory Factor|MLPLI|Melanoma-Derived LPL Inhibitor	Leukemia Inhibitory Factor (LIF) affects many systems, including hematopoietic, embryonic, bone, hepatic, neuronal, and fat tissues. LIF induces MHC class I HLA-G expression by cytotrophoblasts, which is essential in implantation and may facilitate immune tolerance of the conceptus at the maternal-fetal interface. LIF, secreted by ureteric bud cells, converts kidney mesenchyme to epithelia, which then forms nephrons. LIF and BMP2 cytokines signal through different receptors and transcription factors (STATs and SMADs) and act in synergy on neural progenitors to induce astrocytes. Transcriptional co-activator p300 interacts with STAT3 in a cytokine-independent manner and with SMAD1 in a cytokine-dependent manner. Formation of a STAT3/SMAD1 complex, bridged by p300, mediates cooperative signaling of LIF and BMP2 and induction of astrocytes from neuronal progenitors. (from OMIM and NCI)
C20525	Leukoregulin	Cytokine	Leukoregulin	A glycoprotein of 50 kDa secreted by activated natural killer lymphocytes. Leukoregulin shows tumor growth inhibitory activity and enhances membrane permeability and the uptake of cytotoxic drugs by tumors cells without affecting these processes in normal cells.  (from Cytokines Online Pathfinder Encyclopaedia)
C20526	TAF6_Gene	TBP-Associated_Factor_Gene	TAF6 Gene|TAF2E|TAF6|TAF6 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 80kDa Gene|TAFII70|TAFII80|TAFII85	The TAF6 gene at 7q22.1 encodes a protein that interacts with TBP, TAF1, TAF9, TAF12, TFIIE-alpha, and TFIIF-alpha. TAF6 binds weakly to TBP and tightly to TAF1, the largest subunit of TFIID. In the presence of TAF6, TBP, and TAF1, a stable ternary complex forms. TAF6-delta is a specialized isoform of TAF6 with a deletion in its histone fold motif, which is involved in dimerization contacts with TAF9. Unlike TAF6, TAF6-delta forms a TFIID-like complex lacking TAF9. Several distinct apoptotic stimuli induce the expression and caspase-dependent cleavage of TAF6-delta. Elevated expression of TAF6-delta triggers apoptotic cell death and selectively alters cellular transcription, including the induction of the target genes GADD45 and p21 in a signaling pathway that couples apoptotic signals to a reprogramming of RNA polymerase II transcription. (from OMIM 602955 and NCI)
C20527	TAF7_Gene	TBP-Associated_Factor_Gene	TAF7 Gene|TAF2F|TAF7|TAF7 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 55kDa Gene|TAFII55	TFIID is composed of the TATA-binding protein (TBP) and multiple TBP-associated factors (TAFs). The TFIID complex binds to the TATA box in class II promoters and then recruits other factors as well as RNA polymerase II. The TAF7 gene encodes a 55-kD subunit of the TFIID protein complex which is required for transcription by promoters targeted by RNA polymerase II. TAF7 interacts with TAF1, the largest subunit of TFIID, and with multiple transcription activators, including Sp1, YY1, USF, CTF, and adenoviral E1A. The TAF7 mRNA is expressed in all tissues examined. The intronless TAF7 gene is located at chromosome 5q31 on the short arm of chromosome 5. (from OMIM 600573 and NCI)
C20528	CD40_Ligand	Cell_Adhesion_Molecule|Tumor_Necrosis_Factor_Family_Protein	Tumor Necrosis Factor Ligand Superfamily Member 5|CD154|CD154 Antigen|CD40 Ligand|CD40-L|HIGM1|IMD3|T Cell Antigen gp39|T-BAM|TNF-Related Activation Protein|TNFSF5|TRAP|gp39	A cell surface marker on T-cells.  A member of the TNF family.  It regulates B cell function by engaging CD40 on the B cell surface.
C20529	FAS_Ligand	Tumor_Necrosis_Factor_Family_Protein	Tumor Necrosis Factor Ligand Superfamily Member 6|Apoptosis Antigen Ligand 1|CD178 Antigen|CD95 Ligand|FAS-Ligand|FASL|Fas Ligand|Fas-L|TNFSF6	FAS ligand is a TNF family, type II transmembrane protein expressed on many cell types and secreted from T-cells upon TCR ligation by MHC/peptide complexes residing on antigen presenting cells.  FAS ligand triggers cell death by binding to the cell surface receptor FAS, another transmembrane protein member of the TNF receptor family.  FAS ligand is expressed in activated splenocytes and thymocytes, consistent with its involvement in T-cell-mediated cytotoxicity, and in the liver, lung, ovary, and heart, where its function is unclear.  (from OMIM 134638 and NCI)
C20530	Tumor_Necrosis_Factor-C	Tumor_Necrosis_Factor_Family_Protein	Tumor Necrosis Factor C|LTB|LTB Protein|Lymphotoxin Beta|TNFC	Lymphotoxin (LT) is a cytokine that orchestrates lymphoid neogenesis and formation of germinal center reactions. LT exists as a membrane heterotrimer of alpha and beta subunits and is secreted as a homotrimer, LTalpha3.  Also called TUMOR NECROSIS FACTOR BETA. from J Immunol 1999;162:1333-1338
C20531	TAF7L_Gene	TBP-Associated_Factor_Gene	TAF7L Gene|TAF2Q|TAF7-Like RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 50kDa Gene|TAF7L	X chromosome has a predominant role in pre-meiotic stages of mammalian spermatogenesis. The TAF7L gene encodes a 50-kD protein that is a TATA box binding protein-associated factor (TAF) with testis-specific expression in only male germ cells. The TAF7L gene is located at chromosome Xq22.1 on the long arm of chromosome X. (from OMIM 300314)
C20532	CD134_Ligand	Tumor_Necrosis_Factor_Family_Protein	Tumor Necrosis Factor Ligand Superfamily Member 4|CD134 Ligand|Glycoprotein 34|OX40 Ligand|TNFSF4	OX40 ligand is a type II membrane protein and member of the tumor necrosis factor family.  OX40L interaction with its receptor OX40 may induce T-cell activation.  Treatment with an antibody against OX40 ligand (OX40L) prevents rheumatoid arthritis in a murine model of the disease.  (from Eur J Immunol 2000. 30:2815, OMIM 603594, and NCI)
C20533	TRAIL_Protein	Tumor_Necrosis_Factor_Family_Protein	Tumor Necrosis Factor Ligand Superfamily Member 10|APO2 Ligand|APO2L|Apo-2 Ligand|Apo-2L|TL2|TNF-Related Apoptosis Inducing Ligand|TNF-Related Apoptosis Inducing Ligand TRAIL|TNF-Related Apoptosis-Inducing Ligand|TNFSF10|TNFSF10 Protein|TRAIL|TRAIL Protein|Tumor Necrosis Factor Ligand Superfamily, Member 10	Tumor Necrosis Factor Ligand Superfamily Member 10, encoded by the TNFSF10 Gene, is a homotrimeric type II membrane protein that rapidly induces oligomerization of receptor intracellular death domains and apoptosis in a variety of cells. It preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. (From LocusLink, OMIM and NCI)
C20534	TAF8_Gene	TBP-Associated_Factor_Gene	TBN Gene|TAF8 Gene|TBN|Taube Nuss Homolog (Mouse) Gene	No info. in OMIM, PubMed or HUGO as of 12/09/2003.
C20535	Tumor_Necrosis_Factor-Alpha	Tumor_Necrosis_Factor_Family_Protein	Tumor Necrosis Factor-Alpha|TNF|TNF Alpha|TNF-Alpha|TNFA|Tumor Necrosis Factor|Tumor Necrosis Factor Alpha|Tumor Necrosis Factor-alpha (macrophage-derived)	Tumor Necrosis Factor (TNF) - Serum glycoprotein produced by activated macrophages and other mammalian mononuclear leukocytes which has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. It mimics the action of endotoxin but differs from it. It has a molecular weight of less than 70,000 kDa.
C20536	Tumor_Necrosis_Factor-Beta	Tumor_Necrosis_Factor_Family_Protein	Tumor Necrosis Factor-Beta|LT|LTA|Lymphotoxin|Lymphotoxin A|Lymphotoxin Alpha|TNF Beta|TNF-b|TNFSF1	Human tumor necrosis factor-beta protein (205 aa, 22 kDa precursor) is encoded by the human lymphotoxin alpha (LTA) gene. This soluble glycoprotein is released by antigen- or mitogen-activated lymphocytes and is a cytotoxic to other cells. It is involved in allergies and chronic inflammatory diseases.
C20537	TAF9_Gene	TBP-Associated_Factor_Gene	TAF9 Gene|TAF2G|TAF9|TAFII31|TAFII32	RNA polymerase II transcription factor IID is a complex of the TATA binding protein (TBP) and a variety of TBP-associated factors (TAFs). The TAFs are required for activated rather than basal transcription and serve to mediate signals between various activators and the basal transcriptional machinery. The TAF9 gene encodes a 32-kD protein that interacts with the N-terminal domain of p53 at sites identical to those bound by MDM2, the major cellular negative regulator of p53 activity. p53-activated transcription activity is regulated by these 2 proteins competing for the same region of the p53 protein. TAF9 also interacts with GTF2B and the viral transcriptional transactivator VP16. The TAF9 gene is located at chromosome 5q11.2-q13.1 on the long arm of chromosome 5. (from OMIM 600822 and NCI)
C20538	TAF10_Gene	TBP-Associated_Factor_Gene	TAF10 Gene|TAF10|TAF10 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 30kDa Gene|TAF2A, Formerly|TAF2H|TAFII30	Initiation of transcription by RNA polymerase II requires the ordered assembly of basal transcription factors including TFIIA, TFIIB, TATA-binding protein (TBP), TFIIE, TFIIF, TFIIG/TFIIJ, and TFIIH/BTF2 into the TFIID complex, which also includes a number of TBP-associated factors (TAFs). Different activators may interact with specific TAFs to allow the assembly of functionally distinct TFIID complexes that can control transcription of different genes, such as the estrogen receptor, which bind directly to TBP, TFIIB, or both. The TAF10 gene encodes a 30-kD protein that is involved in transcription complex assembly and regulation. TAF10 is necessary for transcriptional activation by the estrogen receptor. The TAF10 gene is located at chromosome 11p15.3 on the short arm of chromosome 11. (from OMIM 600475 and NCI)
C20539	TBP-Associated_Factor_Gene	TFIID_Subunit_Gene	TBP-Associated Factor Gene	Control of transcription by RNA polymerase involves the basal transcription machinery, a collection of proteins which include TFIIB, TFIIE, TFIIF, TATA-box binding protein (TBP), TFIIA and TAF1. These, with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TBP-associated factors (TAFs) encoded by these TBP-Associated Factor Genes. Different TAFs may mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. (from OMIM 600772 and NCI)
C20540	TAF11_Gene	TBP-Associated_Factor_Gene	TAF11 Gene|TAF11|TAF11 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 28kDa Gene|TAFII28	Initiation of transcription by RNA polymerase II requires the ordered assembly of basal transcription factors including TFIIA, TFIIB, TATA-binding protein (TBP), TFIIE, TFIIF, TFIIG/TFIIJ, and TFIIH/BTF2 into the TFIID complex, which also includes a number of TBP-associated factors (TAFs). Different activators may interact with specific TAFs to allow the assembly of functionally distinct TFIID complexes that can control transcription of different genes. The TAF11 gene encodes a 28-kD protein that is a component of the TFIID complex involved in transcription complex assembly and regulation. Different domains of TAF11 interact with TAF13 and TBP. The TAF11/TAF13 heterodimer form a novel histone-like pair in the TFIID complex and they define a novel family of atypical histone fold sequences. The TAF11 gene is located at chromosome 6p21.31 on the short arm of chromosome 6. (from OMIM 600772 and NCI)
C20541	TAF12_Gene	TBP-Associated_Factor_Gene	TAF12 Gene|TAF12|TAF12 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 20kDa Gene|TAF2J|TAFII20	Control of transcription by RNA polymerase II involves the basal transcription machinery, a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. The TAF12 gene at 1p35.2 encodes a protein that interacts directly with TBP as well as with TAF11 and TAF10. (from OMIM 600773, LocusLink 6883 and NCI)
C20542	TAF13_Gene	TBP-Associated_Factor_Gene	TAF13 Gene|TAF13|TAF13 RNA Polymerase II, TATA Box Binding Protein (TBP)-Associated Factor, 18kDa Gene|TAF2K|TAFII18	TAF proteins are tightly associated with TBP in the TFIID complex. Different TAFs mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. The TAF13 gene at 1p13.1 encodes a protein that interacts through distinct domains with TBP but interacts more strongly with TAF11 and TAF10. The TAF11/TAF13 heterodimer form a novel histone-like pair in the TFIID complex and they define a novel family of atypical histone fold sequences. (from OMIM 600774, LocusLink 6884 and NCI)
C20543	TFIID_Subunit_Gene	Basal_Transcription_Factor_Gene	TFIID Subunit Gene	Human transcription initiation factor TFIID is composed of the TATA-binding protein (TBP) and at least 13 TBP-associated factors (TAFs) that collectively or individually are involved in activator-dependent transcription. Initiation of transcription by RNA polymerase II requires the ordered assembly of basal transcription factors including TFIIA, TFIIB, TATA-binding protein (TBP), TFIIE, TFIIF, TFIIG/TFIIJ, and TFIIH/BTF2 into the TFIID complex. Different activators may interact with specific TAFs to allow the assembly of functionally distinct TFIID complexes that can control transcription of different genes. (NCI)
C20544	TFIIA_Subunit_Gene	Basal_Transcription_Factor_Gene	TFIIA Subunit Gene	The three subunits of the TFIIA complex (alpha, bet, and gamma) are encoded by the GTF2A1 and GTF2A2 genes. TFIIA has multiple roles in transcription initiation by RNA polymerase II. First, the association of TFIIA and TBP stabilizes the TBP-TATA element interaction. In so doing, TFIIA also stimulates transcription by displacing TBP-associated repressors and counteracts the ability to inhibit TBP binding to DNA. Second, TFIIA serves as a cofactor for the activators and coactivators. Third, TFIIA is required for the isomerization and extension of TFIID-promoter contacts and for stabilizing interactions between TFIID and initiator sequences. (from PMID 10364255)
C20545	Colony_Stimulating_Factor-2	Colony_Stimulating_Factor	Colony Stimulating Factor 2|CSF|CSF2|Colony Stimulating Factor, Granulocyte-Macrophage|Colony-Stimulating Factor|GM CSF|GM-CSF|GMCSF|Granulocyte Macrophage Colony Stimulating Factor|Granulocyte Macrophage Colony-Stimulating Factor|Granulocyte-Macrophage Colony Stimulating Factor|Granulocyte-Macrophage Colony-Stimulating Factor	An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
C20546	Sonogram	Retired_Concepts	Sonogram
C20547	Fibroblast_Growth_Factor-2	Fibroblast_Growth_Factor	Fibroblast Growth Factor 2|Basic Fibroblast Growth Factor|FGF2|Heparin-Binding Growth Factor 2|Prostatropin|bFGF	A single-chain polypeptide of approximately 15-16 kDa which has been isolated from a variety of cells. It has a 55% amino acid residue identity to acidic fibroblast growth factor and has potent heparin-binding activity. However, in contrast to the acidic fibroblast growth factor, heparin does not potentiate the biological activities of bFGF. The growth factor is an extremely potent inducer of DNA synthesis in a variety of normal diploid mammalian cell types from mesoderm and neuroectoderm lineages and promotes cellular differentiation in vitro. (MSH99)
C20548	Fibroblast_Growth_Factor-1	Fibroblast_Growth_Factor	Fibroblast Growth Factor 1|Acidic Fibroblast Growth Factor|Alpha Fibroblast Growth Factor|Beta-Endothelial Cell Growth Factor|Endothelial Cell Growth Factor, Alpha|Endothelial Cell Growth Factor, Beta|FGF-1|FGF1|Heparin Binding Growth Factor 1|Heparin Binding Growth Factor-1|Prostatropin|aFGF	A modifier of endothelial cell migration and proliferation, Fibroblast Growth Factor 1 may be important in neovascularization.  Acidic Fibroblast Growth Factor and alpha-ECGF are derived from FGF1 by posttranslational processing.  FGF1 causes the foregut endoderm to develop into the liver.  The hepatogenic response is restricted to endoderm tissue, which selectively co-expresses FGF receptors 1 and 4.  Different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis.  FGF1 binding to FGFR2 is accompanied by binding of a heparin decasaccharide.  (from OMIM 131220 and NCI)
C20549	Fibroblast_Growth_Factor-3	Fibroblast_Growth_Factor	Fibroblast Growth Factor 3|FGF-3|FGF3|HBGF-3|INT-2 Proto-Oncogene Protein	Fibroblast Growth Factor 3 is a member of the FGF family.  Fibroblast growth factors have been associated with mesoderm induction and FGF3 has a distinct pattern of expression throughout development in vertebrates.  FGF3 constitutes a signal for induction of the otic vesicle, the primordium of the inner ear.  (from OMIM 164950 and NCI)
C20550	Fibroblast_Growth_Factor-4	Fibroblast_Growth_Factor	Fibroblast Growth Factor 4|FGF-4|FGF4|HBGF-4|Transforming Protein KS3	Fibroblast Growth Factor 4 is a heparin-binding growth factor with significant homology to human fibroblast growth factors that appears to function in limb development in conjunction with the SHH pathway.  (from OMIM 164980 and NCI)
C20551	TBPL1_Gene	TFIID_Subunit_Gene	TBPL1 Gene|TBP-Like 1 Gene|TBPL1|TLF|TLP|TRF2	General transcription factors (GTFs), including TATA box-binding protein (TBP), are necessary for the initiation of transcription of eukaryotic genes. The TBPL1 gene encodes 24-kD TBP-like protein that is a general transcription factor essential for spermiogenesis and required for heterochromatic chromocenter formation in haploid round spermatids. While TBP is ubiquitously expressed, TBPL1 expression is strictly developmentally regulated. TBPL1 mRNAs are expressed in various human tissues ubiquitously but highest expression occurs in testis. TBP and TLF function differentially to control transcription of different sets of genes. TBPL1 interacts with both GTF2A and GTF2B. However, TBPL1 does not bind to the TATA-box nor direct transcription initiation in vitro. The TBPL1 gene is located at chromosome 6q22.1-q22.3 at the long arm of chromosome 6. (from OMIM 605521, PMID 11861477, PMID 10082669)
C20552	PMS2L1_Gene	Gene_with_Unknown_or_Unclassified_Function	PMS2L1 Gene|PMS2L1|PMS3 Gene|Postmeiotic Segregation Increased 2-Like 1 Gene|hPMS3 Gene
C20553	APEXL2_Gene	DNA_Repair_Gene	APEX2 Gene|APE2|APEX Nuclease (Apurinic/Apyrimidinic Endonuclease) 2 Gene|APEXL2|APEXL2 Gene|XTH2	Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. The APEXL2 gene at chromosome Xp11.22 encodes Apurinic/Apyrimidinic Endonuclease 2, a protein that has a weak class II AP endonuclease activity. Most of this protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER). (From LocusLink 27301)
C20554	ERCC1_Gene	DNA_Repair_Gene	ERCC1 Gene|ERCC1|Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 1 (includes overlapping antisense sequence) Gene|UV20	The ERCC1 gene at 19q13.2-q13.3 encodes DNA excision repair protein ERCC-1. Its C-terminal is essential for enzymatic activity of a structure-specific endonuclease and the central region is involved in protein-protein interactions. The ERCC1 gene is involved in UV cross-link repair and nucleotide excision repair (NER). With p53 monitoring DNA damage, either XPA loads and possibly orients an incision complex, containing ERCC1 and other repair factors, to the site of DNA damage or XPA, ERCC1, and ERCC4 proteins form a ternary complex that participates in both damage recognition and incision activities. In the absence of DNA damage, the complex moved freely through the nucleus. Ultraviolet light-induced DNA damage causes a transient immobilization of ERCC1/XPF to engage the complex in a single repair event. Afterwards, the complex regains mobility. (From OMIM 126380 and NCI)
C20555	ERCC2_Gene	DNA_Repair_Gene	ERCC2 Gene|CXPD|EM9|ERCC2|Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 (Xeroderma Pigmentosum D) Gene|MAG|XP, Group D|XP4|XPD|XPD Gene|XPDC	Human ERCC2 Gene (RAD3/XPD Family) encodes 760-aa 87-kDa nuclear DNA Excision Repair Protein ERCC2, an ATP-dependent 5 prime-3 prime DNA helicase and one of six integral subunits of the basal transcription factor BTF2/TFIIH complex. Recruited by transcription preinitiation or DNA damage recognition complexes, ERCC2 is involved in RNA polymerase II transcription, transcription-coupled nucleotide excision DNA repair, and cell cycle regulation. ERCC2/MAT1 anchors CAK complex to the TFIIH complex. CAK inhibits ERCC2 helicase activity; overcome by binding TFIIH subunit p44, which stimulates helicase activity. ERCC2 defects result in XPD, XPD/CS, TTD, and COFS Syndrome. (NCI)
C20556	ERCC3_Gene	DNA_Repair_Gene	ERCC3 Gene|BTF2|BTF2-p89 Gene|Basic Transcription Factor 2 89 kDa Subunit Gene|ERCC3|Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 3 (Xeroderma Pigmentosum Group B Complementing) Gene|GTF2H|RAD25|TFIIH|TFIIH 89 kDa Subunit Gene|TFIIH Basal Transcription Factor Complex Helicase XPB Subunit Gene|XPB	The ERCC3 gene encodes DNA Excision Repair Protein ERCC-3, an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. This protein is also the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. (from LocusLink 2071 and NCI)
C20557	ERCC5_Gene	DNA_Repair_Gene	ERCC5 Gene|ERCC5|ERCM2|ERCM2 Gene|Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 5 (Xeroderma Pigmentosum, Complementation Group G (Cockayne syndrome)) Gene|UVDR|UVDR Gene|XPG|XPG Gene|XPGC|XPGC Gene	The ERCC5 gene encodes XPG-Complementing Protein, which is involved in transcription-coupled repair of UV-induced DNA damage. The encoded protein is a single-strand specific DNA endonuclease that nicks damaged DNA 3-prime to the lesion in nucleotide excision repair as a result of the combined action of the XPB helicase and XPD helicase following sequential assembly of repair proteins at the DNA damage site. In addition, it associates with CSA, CSB, or both proteins at the transcriptional pause sites to facilitate the resumption of transcript elongation without aborting the associated nascent transcript by pushing the stalled RNA polymerase II either forward or backward not only from the damaged site but also from some natural transcription pause sites. Mutational inactivation of XPG causes Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. (from OMIM 133530, LocusLink 2073 and NCI)
C20558	ERCC4_Gene	DNA_Repair_Gene	ERCC4 Gene|ERCC4|Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 4 Gene|RAD1|XPF	The ERCC4 gene at 16p13.3-p13.11 encodes DNA Excision Repair Protein ERCC-4, a DNA repair protein. Nucleotide excision repair (NER) involves incision of a DNA strand on each side of a lesion. The two incisions made during NER are catalyzed by separate DNA endonucleases. A tight protein complex formed between ERCC4 and ERCC1 acts as a structure-specific endonuclease for the 5-prime incision during repair. Without DNA damage, this complex moves freely through the nucleus. Ultraviolet light-induced DNA damage causes a transient immobilization of ERCC4/ERCC1 due to engagement of the complex in a single repair event after assembly of individual nucleotide excision repair factors at sites of DNA damage in a distributive fashion. Causative mutations in the ERCC4 gene and strongly reduced levels of encoded protein can be identified in patients with xeroderma pigmentosum type F. (From OMIM and NCI)
C20559	TREX1_Gene	DNA_Repair_Gene	TREX1 Gene|3 Prime Repair Exonuclease 1 Gene|ATR Interacting Protein Gene|ATR-Interacting Protein Gene|ATRIP|ATRIP Gene|DKFZp434J0310 Gene|DNase III Gene|DRN3 Gene|Deoxyribonuclease III, DnaQ/MutD (E. coli)-Like Gene|FLJ12343 Gene|TREX1|Three Prime Repair Exonuclease 1 Gene	The TREX1 gene at 3p21.3-p21.2 is expressed in all tissues tested and it uses two different open reading frames (ORF). Both ORFs are subject to alternative splicing, resulting in 6 transcript variants. The upstream ORF encodes proteins which interact with ATR (a checkpoint kinase) and localize to intranuclear foci following DNA damage. The TREX1 protein is phosphorylated by ATR, regulates ATR expression, and is an essential component of the DNA damage checkpoint pathway. TREX1 and ATR are mutually dependent partners in cell cycle checkpoint signaling pathways. The downstream ORF encodes isozymes that contain 3-prime-to-5-prime exonuclease activity and the excision of nucleotides from DNA 3-prime termini are required by DNA replication, repair, and recombination. They remove mismatched, modified, fragmented, and normal nucleotides to generate the appropriate 3-prime termini for subsequent steps in the DNA metabolic pathways. (NCI)
C20560	ATR_Gene	DNA_Repair_Gene	ATR Gene|ATR|Ataxia-Telangiectasia and Rad3-Related Gene|FRP1	The ATR gene at 3q22-q24 encodes Ataxia Telangiectasia and Rad3 Related Protein (ATR), a member of the PIK (phosphatidylinositol kinase)-related kinase family that are high molecular weight kinases involved in cell cycle progression, DNA recombination, and the detection of DNA damage. ATR is essential for the viability of human somatic cells. ATR and ATRIP (ATR-interacting protein) are mutually dependent partners in cell cycle checkpoint signaling pathways - ATR phosphorylates ATRIP that regulates ATR expression and is an essential component of the DNA damage checkpoint pathway. ATR phosphorylates checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. ATR may be particularly essential in the early embryo to sense incomplete DNA replication and prevent mitotic catastrophe. (From OMIM 601215 and NCI)
C20561	TREX2_Gene	DNA_Repair_Gene	TREX2 Gene|TREX2|UIP1|XQ28ORF	The TREX2 gene at Xq28 encodes small proteins that are independent 3-prime excision enzymes. In addition, one splice variant uses a different open reading frame and encodes a protein structurally unrelated to the other isoforms. This protein interacts with ubiquitin C-terminal hydrolase 37, which may edit polyubiquitin chains on ubiquitinated substrates. The other TREX2 proteins have 3' exonuclease activity, prefer mismatched 3-prime termini and may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity. The excision of nucleotides from DNA 3-prime termini are required to generate the appropriate 3-prime termini for subsequent steps in the DNA metabolic pathways. The TREX2 gene is ubiquitously expressed.
C20562	TERF2_Gene	Telomere_Maintenance_Gene	TERF2 Gene|TERF2|TRBF2|TRF2|Telomeric Repeat Binding Factor 2 Gene	This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. (LocusLink)
C20563	TERF1_Gene	Telomere_Maintenance_Gene	TERF1 Gene|PIN2|TERF1|TRBF1|TRF|TRF1|Telomeric Repeat Binding Factor (NIMA-Interacting) 1 Gene|hTRF1-AS	This gene encodes a telomere specific protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres throughout the cell cycle and functions as an inhibitor of telomerase, acting in cis to limit the elongation of individual chromosome ends. The protein structure contains a C-terminal Myb motif, a dimerization domain near its N-terminus and an acidic N-terminus. Two transcripts of this gene are alternatively spliced products. (LocusLink)
C20564	TINF2_Gene	DNA_Repair_Gene	TINF2 Gene|TERF1 (TRF1)-Interacting Nuclear Factor 2 Gene|TIN2|TIN2 Gene|TINF2|TRF1-Interacting Nuclear Protein 2 Gene	The TINF2 gene at chromosome 14q11.2 encodes TERF1 (TRF1)-Interacting Nuclear Factor 2 (TINF2), a 50-kD telomere-associated protein. TINF2 regulates telomere length and prevents excessive telomere elongation. TINF2 binds telomeric DNA-binding-protein (TRF1) and is an essential mediator of TRF1 function. Three isoforms, 1, 2, and 3, may be produced by alternative splicing. TINF2 is detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. (From Swiss_Prot, LocusLink)
C20565	LIG4_Gene	DNA_Repair_Gene	LIG4 Gene|DNA Ligase IV Gene|LIG4|Ligase IV, DNA, ATP-Dependent Gene	The LIG4 gene at chromosome 13q33-q34 encodes DNA ligase IV (LIG4), a 96-kD protein that belongs to the ATP-dependent DNA ligase family. LIG4 efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is the activity responsible for the ligation step in nonhomologous DNA end joining and in V(D)J recombination. Defects in LIG4 are the cause of LIG4 syndrome. (OMIM 601837)
C20566	Ku_Subunit_Gene	DNA_Repair_Gene	Ku Subunit Gene	Ku Subunit Genes encode tightly-associated 70-kDa Ku70 Protein and 80-kDa Ku80 Protein subunits of heterodimeric DNA-binding Ku Protein, a DNA damage repair complex that, with the 470-kDa catalytic DNA-PKcs subunit forms DNA-dependent protein kinase, binds and repairs double-stranded DNA breaks, facilitates repair by nonhomologous end-joining, and is involved in V(D)J recombination. Ku also binds to DNA ends with a telomere binding protein and mediates telomere capping to prevent fusion of chromosome ends and genetic instability. KU70 and KU80 form a dyad-symmetrical ring molecule that encircles duplex DNA. Ku is identical to DNA helicase II, an ATP-dependent DNA unwinding enzyme. (NCI)
C20567	XAF1_Gene	Apoptosis_Promoter_Gene	HSXIAPAF1 Gene|HSXIAPAF1|XAF1 Gene|XIAP-Associated Factor 1 Gene	Widely expressed as 3.9-, 4.5-, 6.0-, and 7.0-kb transcripts (highest in heart, ovary; lowest in brain, testis) single-copy 7-exon 18-kb human XAF1 Gene (IAP Family) encodes 317-aa 37-kDa XIAP-Associated Factor 1, containing 3 Cys-rich BIR domains (bind to and inhibit caspases), 7 zinc fingers, and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase activity. Associated with nuclear redistribution of XIAP, cytoplasmic XAF1 appears to antagonize nuclear XIAP inhibition of CASP3 activity. (NCI)
C20568	G22P1_Gene	Ku_Subunit_Gene	G22P1 Gene|G22P1|Ku70|TLAA|Thyroid Autoantigen 70kDa (Ku Antigen) Gene	The G22P1 gene at 22q11-q13 encodes Ku70, a 70-kD subunit of the Ku antigen in DNA repair or transposition. The Ku antigen is a complex that binds to the ends of double-stranded DNA in a cell cycle-dependent manner and Ku70 mediates binding of the Ku complex to DNA. Though a major threat to living cells, eukaryotes can process double-strand DNA breaks (DSBs) by homologous recombination (HR) or nonhomologous end joining (NHEJ). Ku70 acts as a switch between these 2 DSB repair pathways. When present, Ku70 destines DSBs for NHEJ by binding to DNA ends and attracting other factors for NHEJ, including MRE11. When absent, it allows participation of DNA ends and MRE11 in the meiotic HR pathway. Ku70 deficiency facilitates neoplastic growth and the G22P1 gene is important in tumor suppression. The autoantibody has been found in patients with autoimmune thyroid disease (Graves disease) as well as in those with lupus. (from OMIM 152690 and NCI)
C20569	Shunt	Medical_Device	Shunt|shunt	A drainage tube. A surgeon implants or creates a shunt to divert blood or other fluid from one part of the body to another part. For example, a surgeon may implant a tube to drain cerebrospinal fluid from the brain to the abdomen. Or a surgeon may divert normal blood flow by joining two blood vessels together.
C20570	HMG_Family_Gene	Regulatory_Gene	HMG Family Gene	Human HMG Family Genes encode ubiquitous non-histone HMG chromatin proteins originally named according to PAGE electrophoretic mobility, shared physical properties, and association with chromatin. Canonical HMG proteins are subdivided into 3 superfamilies with characteristic functional sequence motifs: HMGB (formerly HMG-1/-2), HMGN (formerly HMG-14/-17), and HMGA (formerly HMG-I/Y/C). DNA-binding HMG proteins appear to have roles in matrix stabilization, ssDNA protection, replication, and transcription that influence cell growth, proliferation, differentiation, and death. (NCI)
C20571	Canonical_HMG_Gene	Retired_Concepts	Canonical HMG Gene
C20572	HMG_Motif_Genes	Retired_Concepts	HMG Motif Genes
C20573	HMGA_Family_Gene	HMG_Family_Gene	HMGA Family Gene	Human HMGA Family Genes encode HMGA proteins that participate in many nuclear processes ranging from chromosome and chromatin mechanics to transcription factors that regulate gene expression. Hence, they influence diverse biological processes including cell growth, proliferation, differentiation and death. HMGA proteins contain three AT-hooks that bind to minor groove AT-rich stretches. HMGA proto-oncogenes promote tumor progression and metastasis when overexpressed. High constitutive HMGA expression is consistently observed in cancers, with increasing concentrations being correlated with increasing malignancy. (NCI)
C20574	HMGB_Family_Gene	HMG_Family_Gene	HMGB Family Gene	Human HMGB Family Genes encode abundant DNA-binding and bending HMG-Box Family proteins (with structure, rather than sequence, specificity) that play an architectural role in nucleoprotein assembly. They have two homologous DNA-binding HMG-box domains connected by a short basic linker to an acidic C-terminus that differs in length. Tail length may be the dominant factor mediating property differences among HMGB proteins and determines DNA-binding properties of the HMG boxes. The tail is essential for DNA-binding. (NCI)
C20575	HMGN_Family_Gene	HMG_Family_Gene	HMGN Family Gene	Human HMGN Family Genes encode nuclear HMGN proteins that bind to nucleosomes, change chromatin architecture, and enhance transcription or replication. They typically contain a Nucleosome Binding Domain that anchors these proteins to nucleosome cores to facilitate changes in higher order chromatin structure. HMGN chromatin association is dynamic and regulated by posttranslational modification; related to cell cycle and transcriptional events. (NCI)
C20576	HMGA1_Gene	HMGA_Family_Gene	HMGA1 Gene|HMG-I(Y) Gene|HMG-R Gene|HMGA1|HMGIY Gene|High Mobility Group AT-Hook 1 Gene|High Mobility Group Protein HMG-I/HMG-Y Gene|High Mobility Group Protein HMGI-Y Gene|High Mobility Group Protein Isoforms I and Y Gene|MGC12816 Gene|MGC4242 Gene|MGC4854 Gene|Nonhistone Chromosomal High-Mobility Group Protein HMG-I/HMG-Y Gene	The HMGA1 gene at 6p21 encodes members of the HMGA1 family (HMGA1a, HMGA1b, HMGA1c) of nonhistone proteins that function as gene transcriptional regulatory proteins. HMGA1 proteins bind specifically to the minor groove of AT-rich sequences of DNA and no posttranslational modifications are necessary for specific DNA binding. The HMGA1 gene is a potential oncogene and c-MYC upregulated HMGA1 expression is involved in neoplastic transformation in Burkitt's lymphoma and pathogenesis of breast cancer. Alternative splicing of a single primary transcript gives rise to distinct but structurally highly similar mRNAs and the isoform proteins. HMGA1a plays an essential role in the assembly and function of a virus-induced enhanceosome in activated transcription of the beta-interferon gene and HMGA1c is important for retinoid dependent transcriptional activity of retinoic acid receptors. (NCI)
C20577	HMGA2_Gene	HMGA_Family_Gene	HMGA2 Gene|BABL|BABL Gene|HMGA2|HMGIC|HMGIC Gene|High Mobility Group AT-Hook 2 Gene|High Mobility Group Protein HMGIC Breakpoint Associated with Benign Lipoma Gene|High Mobility Group Protein Isoform I-C Gene|High-Mobility Group (Nonhistone Chromosomal) Protein Isoform I-C Gene|High-Mobility Group Protein HMGI-C Gene|LIPO|LIPO Gene	The HMGA2 gene encodes an 11-kD protein that functions as an architectural factor and is an essential component of the enhanceosome. The HMGA2 protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. The HMGA2 gene is expressed predominantly during embryogenesis and the HMGA2 protein is regulated by cell cycle-dependent phosphorylation which alters DNA binding affinity. The HMGA2 gene is involved in mesenchymal differentiation, adipogenesis and diet-induced obesity. The HMGA2 gene is rearranged in benign tumors of 8 different types (lipoma, pleomorphic salivary adenoma, and uterine leiomyoma) by translocation that leads to either reexpression of HMGA2 or formation of particular fusion genes. Inactivation of the HMGA2 gene by insertional mutation causes pygmy in mice. The HMGA2 gene is located at chromosome 12q15 on the long arm of chromosome 12.
C20578	HMGB1_Gene	HMGB_Family_Gene	HMGB1 Gene|Amphoterin Gene|Chromosomal Protein, Nonhistone, HMG1 Gene|HMG-1 Gene|HMG1 Gene|HMG3 Gene|HMGB1|High Mobility Group Protein 1 Gene|High-Mobility Group (Nonhistone Chromosomal) Protein 1 Gene|High-Mobility Group Box 1 Gene|Nonhistone Chromosomal Protein HGM1 Gene|SBP-1 Gene|Sulfoglucuronyl Carbohydrate Binding Protein Gene	The HMGB1 gene at 13q12 encodes HMGB1, which is a very abundant and conserved 25-kD protein that plays a central role in the stabilization and/or assembly of several nucleoprotein multifunctional complexes through protein-protein interactions. HMGB1 is essential in a variety of DNA-related biological processes, e.g., V(D)J recombination, the initiation of transcription, and DNA repair. HMGB1 binds DNA without sequence specificity, but has a high affinity for bent or distorted DNA, and bend linear DNA. HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. HMGB1 is structured into two DNA-binding HMG-box domains (A and B) plus a long highly acidic C-terminal domain. The individual A and B boxes exhibit many of the structure-specific properties of the whole protein and the acidic tail modulates the affinity of the tandem HMG boxes in HMGB1 for a variety of DNA targets. (PMID 11497996, PMID 11748221)
C20579	HMGB2_Gene	HMGB_Family_Gene	HMGB2 Gene|HMG-2 Gene|HMG2 Gene|HMGB2|High Mobility Group Box 2 Gene|High Mobility Group Protein 2 Gene|High-Mobility Group (Nonhistone Chromosomal) Protein 2 Gene|High-Mobility Group Box 2 Gene|Nonhistone Chromosomal Protein HMG2 Gene	The HMGG2 Gene at 4q31 encodes HMGB2, which is a member of the non-histone chromosomal high mobility group protein family. The proteins of this family are chromatin-associated and ubiquitously distributed in the nucleus of higher eukaryotic cells. In vitro studies have demonstrated that this protein is able to efficiently bend DNA and form DNA circles. These studies suggest a role in facilitating cooperative interactions between cis-acting proteins by promoting DNA flexibility. This protein is also involved in the final ligation step in DNA end-joining processes of DNA double-strand breaks repair and V(D)J recombination. (From LocusLink)
C20580	HMGB3_Gene	HMGB_Family_Gene	HMGB3 Gene|HMG-2A|HMG-4|HMG2A|HMG4|HMGB3|High-Mobility Group Box 3 Gene	The human HMGB3 Gene at Xq28 encodes HMGB3, which is an high mobility group (HMG) protein, containing 2 HMG box repeats and an acidic C-terminal domain. HMGB3 is expressed predominantly in placenta. (From OMIM and NCI)
C20581	HMGN1_Gene	HMGN_Family_Gene	HMGN1 Gene|HMG14|HMGN1|High-Mobility Group Nucleosome Binding Domain 1 Gene	The HMGN1 Gene at 21q22.2 encodes HMGN1, which is a member of the HMG 14/17 family of proteins. HMGB1 binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. It affects rate of elongation by RNA polymerase II on chromatin templates. HMGN1 may be involved in the process which maintains transcribable genes in a unique chromatin conformation. (From LocusLink and Swiss-Prot)
C20582	HMGN2_Gene	HMGN_Family_Gene	HMGN2 Gene|HMG17|HMGN2|High-Mobility Group Nucleosomal Binding Domain 2 Gene|MGC5629	The HMGN2 Gene at 1p36.1 encodes HMGN2, which is a member of the HMG 14/17 family of proteins. HMGN2 may bind DNA with low specificity and it shares a common DNA-binding motif with other HMG 1/2 family members. It binds to the inner side of the nucleosomal DNA thus altering the interaction between the DNA and the histone octamer. HMGN2 may be involved in the process which maintains transcribable genes in a unique chromatin conformation. (From LocusLink and Swiss-Prot)
C20583	HMGN3_Gene	HMGN_Family_Gene	HMGN3 Gene|HMGN3|High-Mobility Group Nucleosomal Binding Domain 3 Gene|PNAS-24|TRIP7	The HMGN3 Gene at 6q14.3 encodes HMGN3, which binds thyroid hormone receptor beta, but only in the presence of thyroid hormone. Thyroid hormone receptors are hormone-dependent transcription factors that regulate expression of a variety of specific target genes. HMGN3, a member of the HMGN protein family, is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Two transcript variants encoding different isoforms have been found for this gene. (From LocusLink)
C20584	HMGN4_Gene	HMGN_Family_Gene	HMGN4 Gene|HMG17L3|HMGN4|High-Mobility Group Nucleosomal Binding Domain 4 Gene|MGC5145|MGN4|NHC	The HMGN4 Gene at 6p21.3 encodes HMGN4, which is a member of the HMGN protein family. HMGN4 is thought to reduce the compactness of the chromatin fiber in nucleosomes, thereby enhancing transcription from chromatin templates. Transcript variants utilizing alternative polyadenylation signals exist for this gene. (From LocusLink)
C20585	MAP-Kinase_Kinase_Kinase_8	Mitogen-Activated_Protein_Kinase	MAP Kinase Kinase Kinase 8|C-COT|COT Gene Product|COT Proto-Oncogene Serine/Threonine-Protein Kinase|Cancer Osaka Thyroid Oncogene Protein|Ewing Sarcoma Transformant|Ewing Sarcoma Transformant; EST|MAP3K8|MAP3K8 Kinase|Mitogen-Activated Protein Kinase Kinase Kinase 8|p38 MAPK	Encoded by human MAP3K8 Gene (MAP3K Family), cytoplasmic 58-kD (S and G2/M phase specific) and 52-kD isoforms of (Ser/Thr) MAP Kinase Kinase Kinase 8, produced by alternative initiation, activate MAP kinase and JNK kinase pathways in cell cycle regulation. Ser/Thr and autophosphorylated p38 MAPK activates IKB kinases, inducing proteasome-mediated proteolysis of cytoplasmic NFKB and nuclear translocation, and promotes TNF-alpha and IL-2 production during T lymphocyte activation. (NCI)
C20586	Colony_Stimulating_Factor	Hematopoietic_Growth_Factor	Colony Stimulating Factor|CSF|Colony-Stimulating Factors|MGI-1|MGI-1 Protein|Myeloid Cell-Growth Inducer|colony-stimulating factors	A group of glycoprotein growth factors regulating differentiation in myeloid cell lines. These substances act in either paracrine or autocrine fashion on marrow cells, appear to act synergistically in complex and poorly understood ways; each appears to have the ability to exert actions on several lines of progenitor cells, and to influence end cell function.
C20587	Age_Group	Patient_Characteristics_Modifier	Age Group	Subgroups of populations based on age.
C20588	GAG_Protein	Viral_Protein	GAG Protein
C20589	Gene_Amplification_Technique	Molecular_Biology_Techniques	Gene Amplification Technique|Amplification	This technique refers to selectively replicate DNA sequence of interest to multiple extra copies that meet the need of research or health care activity. Polymerase chain reaction (PCR), can be considered a type of man-made gene amplification process.
C20590	Arylesterase	Hydrolase	Arylesterase|A-Esterase|Aromatic Esterase|Aryl-Ester Hydrolase|EC 3.1.1.2|Paroxonase	Acts on many phenolic esters. The reactions of EC 3.1.8.1 aryldialkylphosphatase, were previously attributed to this enzyme. [EC 3.1.1.2 created 1961, modified 1989] (from IUBMB Enzyme Nomenclature).
C20591	SWI-SNF_Family_Complex	Protein_or_Riboprotein_Complex	SWI/SNF Family Complex|Mating Type Switching/Sucrose Nonfermenting Protein	An ATP-dependent chromatin-remodeling complex implicated in the regulation of gene expression, cell-cycle control, and oncogenesis.
C20592	ISWI_Family_Protein	Drosophila_Protein	ISWI Family Protein	The Drosophila gene Imitation SWI (Iswi) encodes a DNA helicase involved in chromatin modeling. It contains a SNF2 related domain, a MYB DNA binding domain, a DEAD/DEAH box helicase, and a helicase C-terminal domain. Iswi is a component of a 215 kD protein NURF, a nucleosome remodeling complex that facilitates the perturbation of chromatin structure in an ATP-dependent manner. Iswi mediates the hydrolysis of ATP during the remodeling of chromatin. It is also a component of the ATP-utilizing chromatin assembly and remodeling factor ACF and of the chromatin accessibility complex CHRAC. This subunit may serve as the energy-transducing component of chromatin-remodeling machines. Iswi belongs to the SNF2/RAD54 helicase family, SNF2L subfamily. Similar sequences have been identified in Caenorhabditis elegans, Homo sapiens, Mus musculus, Plasmodium falciparum, and Saccharomyces cerevisiae. (from FlyBase 0011604 and NCI)
C20593	TFIIH	Basal_Transcription_Factor	TFIIH	TFIIH is a multisubunit factor consisting of at least 5 polypeptides of 92, 62, 43, 40, and 35 kD. The nonphosphorylated form of RNA polymerase II is recruited by TFIIF to the DB complex (a DNA-protein complex composed of the TATA-binding protein subunit of TFIID in association with the TATA motif and TFIIB). This complex is then recognized by TFIIE, TFIIH, and TFIIJ to generate a transcription-competent complex. Phosphorylation of the C-terminal domain of the largest subunit of RNA polymerase II controls the transition from transcription initiation to elongation. The general transcription factor TFIIH contains a kinase activity capable of phosphorylating this domain. Factors that promote the association of RNA polymerase II with the preinitiation complex stimulate this activity. TFIIE, which is required for the stable association of TFIIH with the preinitiation complex, affects the processivity of TFIIH kinase. (from OMIM 189972)
C20594	GTF2A1_Gene	TFIIA_Subunit_Gene	GTF2A1 Gene|GTF2A1|General Transcription Factor IIA, 1, 19/37kDa Gene|TF2A1	Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II and several general initiation factors. One of these factors is TFIIA, which consists of three subunits. The GTF2A1 gene encodes a large 55-kD subunit precursor that is post-translationally processed to form the 35-kD alpha (N-terminal) and 19-kD beta (C-terminal) subunits of the mature TFIIA. Together, these two subunits and the12-kD gamma subunit encoded by the GTF2A2 gene form a six strand beta-barrel that interacts with the TATA-binding protein (TBP) and a separate four-helix bundle positioned just upstream of the TBP-TATA complex. The GTF2A1 gene is located at chromosome 14q31.1 on the long arm of chromosome 14. (from OMIM 600520 and LocusLink 2957)
C20595	RecQ_Helicase_Family_Protein	DNA_Helicase	RecQ Helicase Family Protein	RecQ family proteins are 3'-5' DNA helicases.  All RecQ family proteins include a domain of approx. 450 amino acids that contains seven highly conserved motifs, including a 'Walker A-box' ATP-binding motif and a DExH box which is a characteristic of this family. These motifs are found in several DNA and RNA helicases.
C20596	RecQ_Protein-Like-5_Protein	RecQ_Helicase_Family_Protein	RecQ Protein-Like 5|RecQL5	A member of RecQ helicase family. Northern blot analysis detected RECQL5 expression in almost all tissues tested, with notably strong expression in pancreas and testis.
C20597	ALF_Gene	Transcription_Factor_Gene	ALF Gene|ALF|TFIIA-Alpha/Beta-Like Factor Gene	The ALF gene encodes a 69-kD protein which is a general transcription factor GTF2A1 homolog selectively expressed in testis. In comparison with the organization of GTF2A1, it has conserved regions I and IV and acidic region III but a distinct region II. ALF, in conjunction with GTF2A2 and TBP, binds DNA and allows mRNA transcription. ALF may be functionally identical with GTF2A1 and uniquely important to testis biology. The ALF gene is located at chromosome 2p16.3 on the short arm of chromosome 2.
C20598	GTF2A2_Gene	TFIIA_Subunit_Gene	GTF2A2 Gene|GTF2A2|General Transcription Factor IIA, 2, 12kDa Gene	Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II and the general initiation factors. The first step involves recognition of the TATA element by the TATA-binding subunit (TBP) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF) in TFIID. The GTF2A2 gene encodes the 12-kD gamma subunit of TFIIA. The GTF2A2 gene is located at chromosome 15q21.2 on the long arm of chromosome 15. (from OMIM 600519, LocusLink 2958)
C20599	TBP_Inhibitor_Gene	Transcription_Factor_Gene	TBP Inhibitor Gene	The assembly of transcription complexes at eukaryotic promoters involves a number of distinct steps, including chromatin remodeling and recruitment of a TATA-binding protein (TBP)-containing complexes, the RNA polymerase II holoenzyme. Each of these stages is controlled by positive and negative factors that regulate the interactions of TBP with promoter DNA. The magnitude by which an activated gene is expressed, might depend in part on competition between TBP inhibitors and the holoenzyme for access to the TBP/TATA complex. The first is autorepression, where TBP sequesters its DNA-binding surface through dimerization. Once TBP is bound to DNA, TAF(II)250 and Mot1 induce TBP to dissociate, while NC2 and the NOT complex convert the TBP/DNA complex into an inactive state. TFIIA antagonizes these TBP repressors only in conjunction with the recruitment of the RNA polymerase II holoenzyme by promoter-bound activators. (from PMID 10974559)
C20600	DR1_Gene	TBP_Inhibitor_Gene	DR1 Gene|DR1|Down-Regulator of Transcription 1, TBP-Binding (Negative Cofactor 2) Gene|NC2-Beta	The DR1 gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. DR1 is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. The DR1 protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. DR1 functions as a transcriptional repressor with DRAP1 to inhibit pre-initiation complex formation through interaction with TFIID and DNA. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. This gene is located at chromosome 1p22.1 on the short arm of chromosome 1. (from LocusLink 1810)
C20601	DRAP1_Gene	TBP_Inhibitor_Gene	DRAP1 Gene|DR1-Associated Protein 1 (Negative Cofactor 2 Alpha) Gene|DR1-Associated Protein 1 Gene|DRAP1|NC2-Alpha	Transcriptional repression is a general mechanism for regulating transcriptional initiation in organisms ranging from yeast to humans. The DRAP1 gene at chromosome 11q13.3 encodes a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. DR1 is a repressor that interacts with the TATA-binding protein (TBP) of TFIID and prevents the formation of an active transcription complex by precluding the entry of TFIIA and/or TFIIB into the preinitiation complex. The interaction between DRAP1 and DR1 is required for corepressor function and stabilizes the TBP-DR1-DNA complex. The DRAP1 protein contains a histone fold motif at the N terminus and a proline-rich region at the C terminus. The binding of DRAP1 to DR1 is dependent on the histone fold motif present in each protein. DRAP1 expression facilitates the maintenance of a differentiated state by silencing specific genes. (from OMIM 602289, LocusLink 10589)
C20602	B-TFIID_Subunit_Gene	Basal_Transcription_Factor_Gene	B-TFIID Subunit Gene	Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein (TBP) and TBP-associated factors, or TAFs, in 2 distinct complexes, TFIID and B-TFIID. The majority of TBP is present in the B-TFIID complex, which is composed of TBP and BTAF1. Stable association of TBP and BTAF1 requires the presence of DNA. BTAF1 inhibits TBP-driven RNA polymerase II and III transcription by driving the dissociation of TBP from DNA and freeing the TBP to associate with other TATA boxes or TATA-less promoters. (from OMIM 605191, LocusID 9044)
C20603	BTAF1_Gene	B-TFIID_Subunit_Gene	BTAF1 Gene|BTAF1|BTAF1 RNA Polymerase II, B-TFIID Transcription Factor-Associated, 170kDa (Mot1 Homolog, S. Cerevisiae) Gene|MOT1|TAF(II)170|TAF-172|TAF172|TAFII170	Containing 37 introns, the 130-kb human BTAF1 Gene (SNF2/RAD54 Helicase Family) at 10q22-q23 encodes 1849-aa, 207-kD nuclear DNA-dependent ATPase TAF-172, which harbors 7 motifs characteristic of ATPase proteins; the ATPase region shares 62% amino acid identity with yeast Mot1. RNA polymerase II transcription initiation requires TBP and TAFs in both TFIID and B-TFIID complexes. DNA-dependent association of TAF-172 with TBP forms B-TFIID and regulates transcription. TAF-172 ATPase also drives TBP dissociation from DNA, freeing TBP from the TATA box for additional transcription initiation. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C20604	Affinity	Physical_Phenomena_or_Properties	Affinity	The strength of noncovalent chemical binding between two substances as measured by the dissociation constant of the complex. (On-line Medical Dictionary)
C20605	Developmental_Anatomy	Anatomical_Sciences	Developmental Anatomy|Anatomy, Developmental
C20606	Catchment_Area	Geographic_Area	Catchment Area	Catchment Area refers to the geographic area, and thus the population of individuals who qualify for consideration or inclusion in a study.
C20607	Arteriogram	Medical_Image	Arteriogram|arteriogram	(ar-TEER-ee-o-gram) An x-ray of arteries; the person receives an injection of a dye that outlines the vessels on an x-ray.
C20608	Radiation_Biophysics	Biophysics	Radiation Biophysics
C20609	Synthesis_Chemistry	Chemistry	Synthesis Chemistry|Chemistry, Synthetic|Synthetic Chemistry	A specialized branch of chemistry dealing with the making of compounds, generally from the building blocks to the larger or complex molecules. e.g. making protein from amino acids, or DNA from nucleotides.
C20610	Partition_Coefficient	Chemical_Properties	Partition Coefficient	A constant symbolizing the ratio of a dissolved substance in a two-phase system. (from EPA Terminology Reference System)
C20611	Cytopathology	Pathology	Cytopathology|Cytology and Pathology	A branch of pathology that studies and diagnoses diseases on the cellular level. The most common use of cytopathology is the Pap smear, used to detect cervical cancer at an early treatable stage. (Wikipedia)
C20612	Dephosphorylation	Biochemical_Reaction	Dephosphorylation	The catalyzed removal of phosphate groups from biological molecules, by phosphatases.
C20613	Clonal_Expansion	Cancer_Cell_Growth	Clonal Expansion	Multiplication or reproduction by cell division of a population of identical cells descended from a single progenitor. In immunology, may refer to the clonal proliferation of cells responsive to a specific antigen as part of an immune response. (NCI)
C20614	Primer_Extension	RNA_Analysis	Primer Extension	A method to synthesize cDNA for determining the 5'-untranslated region of a specific mRNA molecule through reverse transcription reaction using complementary oligonucleotides as primers.
C20615	Cancer_Family	Population_Group	Cancer Family	Cancer Family is a group of blood relatives of whom several have had cancer; the mode of aggregation may be genetic and homogeneous, as in familial polyposis of the colon; diverse as in neurofibromatosis; or due to common exposure to a carcinogenic or oncogenic agent, such as a virus. (On-line Medical Dictionary)
C20616	Recombination_Fraction	Genetic_Linkage_Analysis	Recombination Fraction	The percentage of individuals in a population with a non-parental genotype.
C20617	Housekeeping_Gene	Gene	Housekeeping Gene	Genes that are expressed at a fairly consistent level throughout the cell cycle and from tissue to tissue.  Usually involved in routine cellular metabolism. Often used for comparison when studying expression of other genes of interest.
C20618	Quantitative_Genetics	Genetics	Quantitative Genetics
C20619	Granzyme	Serine_Protease	Granzyme	Representing most of the granule content of cytotoxic T cells, Granzymes are serine esterases (endopeptidases) that contain a serine residue at the active site involved in catalysis of internal peptide bonds in a polypeptide or protein. It is not known if these enzymes are required for killing by the cytotoxic T cell.
C20620	Gustation	Sensory_Process	Gustation|Taste	Taste; the faculty of taste, distinguishing substances by means of the taste buds.
C20621	Hematopathology	Pathology	Hematopathology
C20622	Somatic_Cell_Hybridization	Cell_Fusion	Somatic Cell Hybridization	Fusion of 2 somatic cells to form a heterokaryon.
C20623	Immunobiology	Physiology	Immunobiology|Immunophysiology	The study of the immune factors that affect the functioning of the human body
C20624	Embryonic_Induction	Developmental_Process	Embryonic Induction|Induction, Embryonic	A process that stimulates and directs a morphogenetic influence on a population of cells. These populations are often differentiating cells or adjacent neighboring cells that are not fixed on a developmental path. Embryonic induction plays a regulatory role in the development and construction of embryos.
C20625	Tumor_Cell_Invasion	Tumor_Expansion	Tumor Cell Invasion|INV|Invasion|Tumor Invasion	Tumor Cell Invasion is the local spread of tumor cells of a malignant neoplasm through infiltration or destruction of adjacent tissue; for epithelial neoplasms, invasion signifies infiltration beneath the epithelial basement membrane.
C20626	Enzyme_Kinetics	Kinetics	Enzyme Kinetics	A subdiscipline of Kinetics that studies the rates and mechanics of enzymes and enzyme-driven reactions.
C20627	Linker-Scanning_Mutagenesis	Mutagenesis	Linker-Scanning Mutagenesis	In vitro mutagenesis technique in which molecules containing 3' and 5' deletion mutations are combined to regenerate an entire DNA region, differing with the wild type molecule only at the junction of the molecules, which contains a linker DNA.
C20628	Melanogenesis	Biosynthesis	Melanogenesis	Formation of melanin
C20629	Silent_Mutation	Base_Pair_Miscoding	Silent Mutation|Mutation, Silent	A silent mutation alters DNA sequence, but has no apparent detectable effect on a phenotype or a function.
C20630	Neuropathogenesis	Pathogenesis	Neuropathogenesis	The origin or causation of a disease of the nervous system.
C20631	Comparative_Pathology	Comparative_Biology	Comparative Pathology	Biological field of study concerned with the analysis of similarities and differences in specific characteristics between different diseases.
C20632	Pathophysiology	Physiology	Pathophysiology|Dysfunction|Physiopathology	Deranged function in an individual or an organ that is due to a disease. (MedicineNet.com)
C20633	Biochemical_Pathway	root_node	Biochemical Pathway|Metabolic Networks|Pathway|Pathways	An elaboration of the sequence of chemical reactions leading from one compound to another taking place in living tissue.
C20634	Biochemical_Pharmacology	Pharmacology	Biochemical Pharmacology	A branch of pharmacology that studies the biochemical mechanisms responsible for the actions of pharmacologic substances.
C20635	Radiation_Physics	Health_Physics	Radiation Physics	The scientific discipline of the application of physics to the use of ionizing radiation in therapy and in diagnostic radiology; including, by extension, nuclear medicine applications, ultrasound, and magnetic resonance imaging.
C20636	Polymerase	Nucleotidyltransferase	Polymerase	Encoded by Polymerase Genes, Polymerase enzymes catalyze polymerization reactions, especially of nucleotides to polynucleotides. (NCI)
C20637	Sp1_Transcription_Factor	Transcription_Factor	Sp1 Transcription Factor|SP1|Stimulatory Protein 1	Transcription factor SP1 is a DNA-binding protein that interacts with various RNA polymerase II gene promoters containing GC-box elements.  It has contiguous zinc finger motifs and requires zinc for sequence-specific binding to DNA.  The formation of head segments in Drosophila depends on the homologue of the human transcription factor SP1.  (from OMIM 189906 and NCI)
C20638	Community_Psychology	Psychology	Community Psychology
C20639	Mismatch_Repair	DNA_Repair	Mismatch Repair|MMR|Post-Replication Mismatch Repair	The mismatch repair (MMR) system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. This function is critically dependent on the assembly of multimeric complexes involved in mismatch recognition and signal transduction to downstream repair events. (PMID: 11687886)
C20640	Ommaya_Reservoir	Drug_Delivery_System	Ommaya Reservoir|Ommaya reservoir	(o-MY-a REZ-er-vwahr) A device surgically placed under the scalp and used to deliver anticancer drugs to the fluid surrounding the brain and spinal cord.
C20641	Performance_Status	Personal_Attribute	Performance Status|performance status	A measure of how well a patient is able to perform ordinary tasks and carry out daily activities.
C20642	Stereotaxis	Three_Dimensional_Imaging	Stereotaxis|stereotaxis	(stair-ee-o-TAK-sis) Use of a computer and scanning devices to create three-dimensional pictures. This method can be used to direct a biopsy, external radiation, or the insertion of radiation implants.
C20643	Schiller_Test	Histological_Techniques|Test|Test_Generic	Schiller Test|Schiller test|Schiller's Test	(SHIL-er) A test in which iodine is applied to the cervix. The iodine colors healthy cells brown; abnormal cells remain unstained, usually appearing white or yellow.
C20644	High_Resolution_Computed_Tomography	Computed_Tomography	High Resolution Computed Tomography	Defined as thin section (1-2 mm collimation) CT optimized by using a high-spatial-frequency (bone) algorithm. (from Radiol Clin North Am 1991;29:1043-9)
C20645	Spiral_CT	Computed_Tomography	Spiral CT|Helical CT|SCT|Spiral Acquisition CT|Spiral Computed Tomography|Spiral Volumetric CT|Volumetric CT|helical computed tomography|spiral CT scan	A detailed picture of areas inside the body.  The pictures are created by a computer linked to an x-ray machine that scans the body in a spiral path.
C20646	Topoisomerase	Isomerase	Topoisomerase	Enzymes that change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand of DNA; type I topoisomerase of E. coli (omega protein) relaxes negatively supercoiled DNA and does not act on positively supercoiled DNA. Type II topoisomerases cut both strands of DNA; type II topoisomerase of E. coli (DNA gyrase) increases the degree of negative supercoiling in DNA and requires ATP. It is inhibited by several antibiotics, including nalidixic acid and ovobiocin. (The Dictionary of Cell Biology, 2nd ed., http://www.mblab.gla.ac.uk/~julian/dict.html)
C20647	TFIIE_Subunit_Gene	Basal_Transcription_Factor_Gene	TFIIE Subunit Gene	TFIIE Subunit Genes encode 2 subunit proteins of 56 kD and 34 kD. TFIIE is a heterotetramer of 2 alpha and 2 beta subunits, both subunits being required for optimal basal-level transcription. Both subunits are essential to form a stable preinitiation complex. High levels of gene transcription by RNA polymerase II depend on high rates of transcription initiation and reinitiation. Initiation requires recruitment of the complete transcription machinery to a promoter, a process facilitated by activators and chromatin remodeling factors. Reinitiation occurs through a different pathway. After initiation, a subset of the transcription machinery remains at the promoter, forming a platform for assembly of a second transcription complex as a scaffold for formation of a functional reinitiation complex. Formation of this scaffold depends on ATP and TFIIH. Some activators and Mediator may promote high levels of transcription. (from OMIM 189962).
C20648	GTF2B_Gene	Transcription_Factor_Gene	GTF2B Gene|GTF2B|General Transcription Factor IIB Gene|RNA Polymerase II Transcription Factor IIB Gene|TF2B Gene|TFIIB Gene|Transcription Factor IIB Gene	The TFIIB gene encodes a protein that is a general transcription factor and plays a central role in preinitiation complex assembly. TFIIB is one of the ubiquitous factors required for transcription initiation by RNA polymerase II. TFIIB localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. TFIIB provides a bridge between promoter-bound TFIID and RNA Polymerase II. TFIIB possesses sequence-specific DNA-binding ability and interacts with the TFIIB -recognition element (BRE), present in many promoters. BRE suppresses the basal level of transcription elicited by a core promoter, which increases the amplitude of transcriptional stimulation in the presence of an activator where an activator can disrupt the TFIIB-BRE interaction within a promoter-bound complex. The TFIIB gene is located at chromosome 1p22-p21 on the short arm of chromosome 1. (from PMID 11711430, LocusLink 2959)
C20649	GTF2E1_Gene	TFIIE_Subunit_Gene	GTF2E1 Gene|GTF2E1|General Transcription Factor IIE, Polypeptide 1|General Transcription Factor IIE, Polypeptide 1, Alpha 56kDa Gene|TF2E1 Gene	The GTF2E1 gene encodes a 56-kD protein that is the alpha subunit of RNA polymerase II transcription initiation factor IIE. GTF2E1 is required in vitro with GTF2E2 for the formation of a stable preinitiation complex and for basal-level and Sp1-activated transcription. This gene is located at chromosome 3q21-q24 on the long arm of chromosome 3. (from LocusLink 2960)
C20650	GTF2E2_Gene	TFIIE_Subunit_Gene	GTF2E2 Gene|GTF2E2|General Transcription Factor IIE, Polypeptide 2, Beta 34kDa Gene|TF2E2 Gene	The GTF2E2 gene encodes a 34-kD protein that is the beta subunit of RNA polymerase II transcription initiation factor IIE. GTF2E2 is required in vitro for the formation of a stable preinitiation complex and for basal-level and Sp1-activated transcription. The GTF2E2 gene is located at chromosome 8p21-p12 on the short arm of chromosome 8. (from LocusLink 2961)
C20651	TFIIF_Subunit_Gene	Basal_Transcription_Factor_Gene	TFIIF Subunit Gene	Human TFIIF Subunit Genes, GTF2F1 Gene and GTF2F2 Gene, encode similar alpha (517-aa, 58-kDa, phosphorylated) and beta (249-aa, 28-kDa) subunits of heterodimeric nuclear general transcription initiation factor TFIIF, which binds to and recruits RNA polymerase II to the initiation complex in collaboration with TFIIB. The beta subunit shows ATP-dependent DNA-helicase activity and the region that binds RNA polymerase exhibits similarities with prokaryotic sigma factors. (NCI)
C20652	GTF2F1_Gene	TFIIF_Subunit_Gene	GTF2F1 Gene|GTF2F1|General Transcription Factor IIF, Polypeptide 1, 74kDa Gene|RAP74 Gene|TF2F1 Gene|TFIIF Alpha Gene	The GTF2F1 gene encodes a 74-kD protein that is the large subunit of TFIIF, one of at least six general transcription factors participating in accurate initiation by RNA polymerase II. TFIIF can bind directly to RNA polymerase II and decrease the affinity of RNA polymerase II for nonspecific DNA. TFIIF acts at an intermediate stage in initiation complex formation after TFIID firmly associates with DNA, but coincidentally with or immediately after RNA polymerase II binding to DNA, and before the recruitment of TFIIE. GTF2F1 lacks obvious DNA or RNA helicase motifs. GTF2F1 interacts with GTF2F2, the small subunit of TFIIF, to direct accurate transcription initiation by RNA polymerase II. This interaction is necessary for transcriptional activation by serum response factor. The GTF2F1 is located at chromosome 19p13.3 on the short arm of chromosome 19. (from OMIM 189968, OMIM 600246)
C20653	GTF2F2_Gene	TFIIF_Subunit_Gene	GTF2F2 Gene|GTF2F2|General Transcription Factor IIF, Polypeptide 2, 30-kD Gene|RAP30 Gene|TF2F2 Gene|TFIIF Beta Gene	The GTF2F2 gene encodes a 30-kD protein that is the small subunit of the RNA polymerase II transcription factor TFIIF. TFIIF affects RNA polymerase II activity both during the initiation and elongation stages of RNA transcription. TFIIF assists TFIIB in recruiting RNA polymerase II into a preinitiation complex. It also affects RNA transcription by suppressing transient pausing of the polymerase at locations on the DNA template. These 2 activities are controlled by distinct functional domains. The initiation activity is mediated by GTF2F2 C-terminal sequences (which include a DNA binding domain) and the elongation activity is mediated by sequences immediately upstream of the C-terminus, where RNA polymerase II is thought to bind, as well as by sequences near the GTF2A2 N-terminus. The GTF2A2 gene is located at chromosome 13q14 on the long arm of chromosome 13. (from OMIM 189969)
C20654	TFIIH_Subunit_Gene	Basal_Transcription_Factor_Gene	TFIIH Subunit Gene	For transcription initiation, the nonphosphorylated RNA polymerase II is recruited by TFIIF to the DB complex. This complex is recognized by TFIIE, TFIIH, and TFIIJ to form a transcription-competent complex. Phosphorylation of the C-terminal domain of the largest subunit of RNA polymerase II controls the transition from transcription initiation to elongation and TFIIH contains a kinase activity for phosphorylating this domain. Factors that promote the association of RNA polymerase II with the preinitiation complex stimulate this activity. TFIIE, which is required for the stable association of TFIIH with the preinitiation complex, affects the processivity of TFIIH kinase. TFIIH is a multisubunit factor of at least 5 proteins of 92, 62, 43, 40, and 35 kD. A 52-kD subunit has also been identified as a component of the TFIIH core, along with p89, p62, p44, and p34. (from OMIM, LocusLink and NCI)
C20655	TFIIH_Core_Subunit_Gene	TFIIH_Subunit_Gene	TFIIH Core Subunit Gene	Human TFIIH Core Subunit Genes, GTF2H1, GTF2H2, GTF2H3, GTF2H4, ERCC2, and ERCC3, encode six subunits of the nuclear core-TFIIH basal transcription factor. These subunits are involved in transcription-coupled DNA nucleotide excision repair, and basal RNA polymerase II transcription when complexed to CAK (CDK7/Cyclin H/MAT1). Phosphorylated 548-aa 62-kDa GTF2H1 contains 2 BSD domains. The 395-aa 44-kDa GTF2H2 contains a C4-type zinc finger and a VWFA domain. The N-terminus interacts with and regulates XPD, while the C-terminus promotes escape of RNAPII from the promoter. GTF2H2 also interacts with XPB, p62, and p34. Containing a C4-type zinc finger, 303-aa 34-kDa GTF2H3 anchors XPB. ATP-dependent 760-aa 87-kDa ERCC2 DNA helicase anchors CAK to core-TFIIH; interaction with p44 stimulates helicase activity. ERCC3 is a 782-aa 89-kDa ATP-dependent DNA helicase. (NCI)
C20656	GTF2H1_Gene	TFIIH_Core_Subunit_Gene	GTF2H1 Gene|GTF2H1|General Transcription Factor IIH, Polypeptide 1|General Transcription Factor IIH, Polypeptide 1, 62kDa Gene	The GTF2H1 gene encodes a 62-kD protein that is a subunit of TFIIH, a multisubunit factor consisting of at least 10 proteins. TFIIH is involved in several biological fundamental mechanisms of the cell: transcription, nucleotide excision repair and cell cycle regulation. p62 is one of the six subunits that constitutes the core of TFIIH versus the holoenzyme, which contains, in addition, the ternary kinase CAK complex. p62 does not contain any known specific motif or enzymatic activities and may only have an architectural role, around which the other proteins with specific functions. The p62 promoter has two start sites and the regulatory regions, but lacks classical elements such as CCAAT and TATA boxes. The p62 gene is expressed in testis tissue. The GTF2H1 gene is located at chromosome 11p15.1-p14 on the short arm of chromosome 11. (from PMID 11266560, PMIM 9630526)
C20657	XPD_Gene	Retired_Concepts	ERCC2 Gene|XP, Group D|XP4|XPD|XPD Gene|XPDC	Human ERCC2 Gene (RAD3/XPD Family) encodes 760-aa 87-kDa nuclear DNA Excision Repair Protein ERCC2, an ATP-dependent 5 prime-3 prime DNA helicase and one of six integral subunits of the basal transcription factor BTF2/TFIIH complex. Recruited by transcription preinitiation or DNA damage recognition complexes, ERCC2 is involved in RNA polymerase II transcription, transcription-coupled nucleotide excision DNA repair, and cell cycle regulation. ERCC2/MAT1 anchors CAK complex to the TFIIH complex. CAK inhibits ERCC2 helicase activity; overcome by binding TFIIH subunit p44, which stimulates helicase activity. ERCC2 defects result in XPD, XPD/CS, TTD, and COFS Syndrome. (NCI)
C20658	Mediator_Complex_Component_Gene	Transcription_Factor_Gene	Mediator Complex Component Gene	Regulation of mRNA synthesis requires intermediary proteins that transduce regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Mediator Complex Component Genes encode the mediator complex, one type of intermediary and which consists of approximately 20 polypeptides. It is physically associated with RNA polymerase II and is essential for transcriptional activation. (from OMIM 602984)
C20659	MED6_Gene	Mediator_Complex_Component_Gene	MED6 Gene|MED6|Mediator of RNA Polymerase II Transcription, Subunit 6 Homolog (Yeast) Gene|NY-REN-28	Human MED6 Gene (MED6 Family) encodes 246-aa 28-kDa nuclear Mediator of RNA Polymerase II Transcription Subunit 6 Homolog, a coactivation component of transcriptional mediator complexes involved in transcriptional activation and repression. Transcription requires intermediary proteins that transduce signals from regulatory activator proteins to the basal transcription machinery at the core promoter. Physically associated with RNA polymerase II and essential for transcriptional activation, MED6 appears required for transcriptional activation of most of the RNA polymerase II-transcribed genes and not to be involved in uninduced or repressed transcription, transcription of constitutively expressed genes, or transcription by RNA polymerases I or III. MED6 is a subunit of the multiprotein ARC/DRIP and CRSP complexes. (NCI)
C20660	RNA_Polymerase-II_Subunit_Gene	Polymerase_Gene	RNA Polymerase II Subunit Gene	RNA polymerase II subunit genes encode DNA-dependent RNA polymerase II, a complex multisubunit enzyme that is responsible for the transcription of protein-coding genes. Ten to 14 subunits encoded by these genes range in size from 220 to 10 kD. The complex interacts with the promoter regions of genes as well as with a variety of elements and transcription factors to determine essentially all of the parameters that govern transcription, e.g., tissue and development specificity, stress response, etc. A fraction of the large subunit of Pol II (Pol II LS) is ubiquitinated after exposing cells to UV radiation or cisplatin. (NCI)
C20661	POLR2A_Gene	RNA_Polymerase-II_Subunit_Gene	POLR2A Gene|POLR2|POLR2A|POLRA|Polymerase (RNA) II (DNA Directed) Polypeptide A, 220kDa Gene|RPB1|RPBh1|RPO2 Gene|RPOL2 Gene|RpIILS|hRPB220|hsRPB2	Human POLR2A Gene (RNA Polymerase Beta Prime Chain Family) encodes nuclear 1970-aa 220-kD DNA Directed RNA Polymerase II Polypeptide A, the largest of 12 subunits of RNA polymerase II that catalyzes transcription of DNA in eukaryotes into mRNA precursor. The C-terminal domain (CTD) heptapeptide repeats contain highly phosphorylated activating serine and threonine residues. POLR2A and other subunits form the polymerase DNA binding domain, where the DNA template is transcribed. POLR2A couples transcription with pre-mRNA processing. The hyperphosphorylated CTD interacts with FNBP3 and recruits factors for mRNA capping, splicing, and 3'-processing. POLR2A interacts with SAFB/SAFB1. POLR2A is ubiquitinated after damage of genes repaired by transcription-coupled repair.  (NCI)
C20662	Nursing_Informatics	Informatics	Nursing Informatics
C20663	TFIIIC_Subunit_Gene	Basal_Transcription_Factor_Gene	TFIIIC Subunit Gene	RNA polymerases are unable to initiate RNA synthesis in the absence of general transcription factors (GTFs). GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. TFIIIC Subunit Genes encode the TFIIIC protein complex that is essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. The TFIIIC complex interacts with TFIIIB in the recruitment of RNA polymerase III. Transcription by RNA polymerase III is enhanced during viral infection by the expression of immediate early proteins of adenovirus and pseudorabies virus. (from OMIM 604888)
C20664	GTF3C3_Gene	TFIIIC_Subunit_Gene	GTF3C3 Gene|GTF3C3|General Transcription Factor IIIC, Polypeptide 3, 102kDa Gene|TFIIIC102 Gene	The GTF3C3 gene encodes a 102-kD protein that is a subunit of GTF3C and contains N-terminal basic and acidic regions, a central acidic region, a C-terminal helix-loop-helix region, and 11 tetratricopeptide repeats. The GTF3C complex interacts with GTF3B in the recruitment of RNA polymerase III. The GTF3C3 gene is located at chromosome 2q33.1 on the long arm of chromosome 2. (from OMIM 604888)
C20665	GTF3C1_Gene	TFIIIC_Subunit_Gene	GTF3C1 Gene|GTF3C1|General Transcription Factor IIIC, Polypeptide 1, Alpha 220kDa Gene	The GTF3C1 gene encodes a 220-kD protein that is a subunit of general transcription factor GTF3C, a component of RNA polymerase III. GTF3C is a multisubunit complex that binds B box promoter elements. GTF3C1 binds to the box B promoter element. GTF3C1 is absolutely required for RNA polymerase III transcription of 5S RNA, tRNA, and VAI RNA genes. The GTF3C1 gene is located at chromosome 16p12 on the short arm of chromosome 16. (from OMIM 603246, LocusLink 2975)
C20666	GTF3C2_Gene	TFIIIC_Subunit_Gene	GTF3C2 Gene|GTF3C2|General Transcription Factor IIIC, Polypeptide 2, Beta 110kDa Gene	The GTF3C2 gene at 2p23.3 encodes a 110-kD protein that is the beta subunit of general transcription factor GTF3C, a component of RNA polymerase III. RNA polymerases need general transcription factors (GTFs) to initiate RNA synthesis. GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. GTF3C2 is expressed in all 16 human tissues examined with moderate expression in lung, skeletal muscle, kidney, ovary, and colon and low in heart, brain, placenta, liver, pancreas, spleen, thymus, prostate, testis, small intestine, and peripheral blood leukocytes. The GTF3C2 protein contains stretches of acidic and basic regions, potential acidic and basic helices, and 5 putative WD40 repeats. (from OMIM 604883, LocusLink 2976)
C20667	GTF3C4_Gene	TFIIIC_Subunit_Gene	GTF3C4 Gene|GTF3C4|General Transcription Factor IIIC, Polypeptide 4, 90kDa Gene|TFIIIC90	The GTF3C4 gene encodes a 90-kD protein that is a subunit of general transcription factor GTF3C. RNA polymerases need general transcription factors (GTFs) to initiate RNA synthesis. GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. The GTF3C4 protein interacts with GTF3B in the recruitment of RNA polymerase III. GTF3C4 has intrinsic histone acetyltransferase activity. GTF3C4 contains 2 potential zinc finger motifs at the C-terminus. The GTF3C4 gene is located at chromosome 9q34.3 on the long arm of chromosome 9. (from OMIM 604892, LocusLink 9329)
C20668	GTF3C5_Gene	TFIIIC_Subunit_Gene	GTF3C5 Gene|GTF3C5|General Transcription Factor IIIC, Polypeptide 5, 63kDa Gene|TFIIIC63	The GTF3C5 gene encodes a 63-kD protein that is a subunit of general transcription factor GTF3C. RNA polymerases need general transcription factors (GTFs) to initiate RNA synthesis. GTFs assemble in a complex on the DNA promoter and recruit the RNA polymerase. GTF3C family proteins are essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA of both cellular and viral origin. The GTF3C complex interacts with GTF3B in the recruitment of RNA polymerase III. The GTF3C5 protein contains a central helix-turn-helix motif and a C-terminal acidic region. The GTF3C5 gene is located at chromosome 9q34 on the long arm of chromosome 9. (from OMIM 604890, LocusLink 9328)
C20669	TFIIIB_Subunit_Gene	Basal_Transcription_Factor_Gene	TFIIIB Subunit Gene	Human TFIIIB Subunit Genes, BDP1, BRF1, and, BRF2, encode protein subunits of RNA Polymerase III Transcription Initiation Factor IIIB, required for RNA polymerase III transcription. Transcription begins with TFIIIC recognition of promoter A and B boxes and TFIIIA, TFIIIB, and RNA polymerase III binding. 90-kDa BRF1 contains a C-terminal HMG2-related region and an N-terminal TFII2B-related sequence. 50-kDa BRF2 has a zinc ribbon domain and a core domain, necessary for complex formation with DNA. Involved in nucleation of a polymerase III initiation complex, BRF2 does not directly bind DNA but interacts with TBP, which binds cooperatively to the promoter. TBP, an essential component of TFIIIB, binds the highly charged C-terminus of BRF1. Highly hydrophilic BDP1 contains a DNA-ligase A1 ATP-dependent binding site and several potential phosphorylation sites. (NCI)
C20670	BRF1_Gene	TFIIIB_Subunit_Gene	BRF1 Gene|BRF Gene|BRF1|BRF1 Homolog, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB (S. Cerevisiae) Gene|General Transcription Factor 3B, 90-kD Subunit|TAF3B2 Gene|TAF3C, Formerly|TFIIIB90 Gene	The BRF1 gene at 14q encodes a 90-kD protein that is a subunit of RNA polymerase III, TFIIIB. BRF1 is essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and virus-associated RNA. Transcription of these RNAs begins with TFIIIC recognition of internal promoter elements (A and B boxes), followed by sequential binding of TFIIIB and RNA polymerase III. 5S RNA transcription is similar except that the binding of TFIIIA to a distinct set of internal promoter elements is required for TFIIIC recruitment. An essential component of TFIIIB, TATA box-binding protein (TBP), is required by all 3 classes of eukaryotic RNA polymerases. The C terminus of BRF1 binds TBP. BRF1 contains a high mobility group protein-2 (HMG2)-related region in the highly charged C terminus and a sequence related to TFII2B in the N terminus. Deletion of either half of the protein abolished activity. (NCI)
C20671	BDP1_Gene	TFIIIB_Subunit_Gene	BDP1 Gene|B Double Prime 1, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB Gene|BDP1|KIAA1689|TFNR	The BDP1 Gene encodes a highly hydrophilic protein that is a subunit of RNA Polymerase III Transcription Initiation Factor IIIB.  BPD1 is required for transcription from the Ad2 VAI and human U6 RNA polymerase III promoters.  BDP1 binds the U6 promoter region in vivo as part of the U6 initiation complex.  The BDP1 protein contains a bipartite nuclear localization signal, a DNA-ligase A1 ATP-dependent binding site, and a second bipartite nuclear localization signal in the C terminus.  The protein has several potential phosphorylation sites.  Weak expression of 9.5-, 3.1-, and 1.6-kb transcripts is detected in all tissues examined, and a 1.9-kb transcript expressed only in brain.  A strong signal is present at 9.5 and 1.9 kb in cerebellum, and a weak signal in all other brain areas.  Adult human tissues show 5 protein bands ranging from 55 to 250 kD.  The BDP1 gene is located at chromosome 5q13 on the long arm of chromosome 5.  (from OMIM)
C20672	BRF2_Gene	TFIIIB_Subunit_Gene	BRF2 Gene|BRF2, Subunit of RNA Polymerase III Transcription Initiation Factor, BRF1-Like Gene|BRFU|TFIIIB50	The BRF2 gene encodes a 50-kD protein that is a subunit of RNA polymerase III transcription initiation factor. BRF2 is involved in the nucleation of a polymerase III-specific small nuclear RNA (snRNA) transcription initiation complex. BRF2 does not directly bind DNA but it interacts with the TATA-binding protein (TBP), and they then bind cooperatively to the polymerase III promoter region of snRNA. The BRF2 protein has a zinc ribbon domain and a core domain. The TBP/BRF2 complex does not have strict requirements for sequence motifs outside the TATA box. Arg235 and phe250 of TBP, and repeat 2 of the BRF2 core domain, are necessary for complex formation with DNA. BRF2 also forms a stable complex on the TATA box of the polymerase II-specific adenovirus major late promoter. The BRF2 gene is located at chromosome 8p11.23 on the short arm of chromosome 8. (from OMIM 607013, LocusLink 55290, and NCI)
C20673	Transcription_Coactivator_Gene	Transcription_Coregulator_Gene	Transcription Coactivator Gene	RNA polymerase II transcription of Class II genes involves the TFIID transcription complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIG/J, and TFIIH, as well as gene-specific factors that include TAFs, which interact with regulatory protein activation domains to enhance transcription. A second group of cofactors includes PC1, PC2, and PC3, which have a strong positive influence on transcription. The combined action of general and gene-specific regulators encoded by Transcription Coactivator Genes enhances gene expression. (NCI)
C20674	X-Chromosome_Inactivation	Gene_Regulation	X-Chromosome Inactivation|X Inactivation	A human early embryonic event in which in any given cell one of a female's two X chromosomes becomes inactivated and converted into a Barr body.  After inactivation has occurred, all descendants of that cell have the same inactivated X chromosome. Thus, X-inactivation creates cell clones with differing effective gene content. An organism whose cells vary in effective gene content and hence in the expression of a trait, is called a genetic mosaic.
C20675	PC4_Gene	Transcription_Coactivator_Gene	PC4 Gene|Activated RNA Polymerase II Transcription Cofactor 4 Gene|P15|PC4|RPO2TC1	The PC4 gene encodes Activated RNA Polymerase II Transcription Cofactor 4, which is a general transcriptional coactivator for RNA polymerase II. This protein mediates transcriptional activation of class II genes. It is a single-stranded DNA-binding protein that functions through its interaction with TAFs. (from OMIM, LocusLink)
C20676	PSIP1_Gene	Transcription_Coactivator_Gene	PSIP1 Gene|LEDGF|P52|PAIP|PC4 and SFRS1 Interacting Protein 1 Gene|PSIP1	The PSIP1 gene at 9p22.2 encodes 2 transcriptional coactivators (p52 and p75) that are alternatively spliced products. The p52 and p75 proteins share a region, but show distinct coactivator properties. Both p52 and p75 interact strongly with the VP16 activation domain and several components of the general transcriptional machinery. p52 is a potent broad-specificity coactivator, whereas p75 is less active for most activation domains. p52 interacts not only with transcriptional activators and general transcription factors to enhance activated transcription, but also with the essential splicing factor ASF/SF2 to modulate ASF/SF2-mediated pre-mRNA splicing. The majority of endogenous p52 is colocalized with ASF/SF2 in the nucleoplasm. In addition to functioning as a transcriptional coactivator, p52 may also act as an adaptor to coordinate pre-mRNA splicing and transcriptional activation of class II genes. (from OMIM 603620)
C20677	Microscope	Imaging_Device	Microscope	A microscope is an optical instrument that uses a combination of lenses to produce magnified images of very small objects
C20678	Robot	Diagnostic_Therapeutic_and_Research_Equipment	Robot|Robots	A mechanical device that sometimes resembles a living animal and is capable of performing a variety of often complex human tasks on command or by being programmed in advance.
C20679	Serine-Threonine_Phosphorylation	Protein_Phosphorylation	Serine/Threonine Phosphorylation	Serine/Threonine Phosphorylation involves covalent linkage of a phosphate group (from a donor compound such as ATP) with a serine or threonine residue of a Protein Kinase acceptor, often as a mechanism of kinase activity regulation.
C20680	Electrolaryngeal_Speech	Alaryngeal_Speech	Electrolaryngeal Speech|Artificial Laryngeal Speech
C20681	Tracheoesophageal_Speech	Alaryngeal_Speech	Tracheoesophageal Speech|Tracheo-Esophageal Speech
C20682	PPARBP_Gene	Transcription_Coactivator_Gene	PPARBP Gene|CRSP1|CRSP200|DRIP230|PBP|PPAR Binding Protein Gene|PPARBP|PPARGBP|RB18A|TRAP220|TRIP2	The PPARBP gene at 17q12-q21.1 encodes a 220-kD protein that is global transcription coactivator for the nuclear receptor superfamily. Two LXXLL motifs in PPARBP are necessary and sufficient for binding to nuclear receptors, including thyroid hormone receptor and estrogen receptor. PPARBP is essential for many physiologic processes and also has gene- and activator-selective functions. PPARBP is required for PPAR gamma 2-stimulated adipogenesis and may play a role in mammary epithelial differentiation and breast carcinogenesis. High levels of PPARBP expression are detected in primary breast cancers and breast cancer cell lines. This can happen independent of gene amplification though the latter occurs. PPARBP, in a protein-protein interaction, regulates p53 transactivating activity. An 8.5-kb transcript is expressed in all tissues examined except kidney, with highest expression in heart. (from OMIM, LocusLink)
C20683	CRSP2_Gene	Sp1_Activation_Cofactor_Gene	CRSP2 Gene|CRSP150|CRSP2|CSRP|CXORF4|Cofactor Required for Sp1 Transcriptional Activation, Subunit 2, 150kDa Gene|EXLM1|RGR1|TRAP170	Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP2 gene at Xp11.4-p11.2 encodes a 150-kD protein that is a subunit of the CRSP complex. The CRSP2 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. CRSP2 contains a cytochrome C family heme-binding motif and a bipartite nuclear localization signal. CRSP2 is expressed as 6.5- and 8-kb mRNAs predominantly in skeletal muscle. (from OMIM 300182, LocusLink 9282)
C20684	Chromogranin-B	Chromogranin	Chromogranin B|CHGB|Secretogranin B|Secretogranin I	Chromogranin B is a tyrosine-sulfated secretory protein found in a wide variety of peptidergic endocrine cells.  Chromogranin functions as a neuroendocrine secretory granule protein which may be the precursor for other biologically active peptides. (LocusLink)
C20685	Secretogranin-II	Chromogranin	Secretogranin II|Chromogranin C|EM66 Precursor|SCG2|Secretogranin II Precursor|Secretoneurin Precursor|SgII	The protein is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins.  Studies in rodents suggest that the full length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles.  The full length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. (LocusLink)
C20686	Sp1_Activation_Cofactor_Gene	Transcription_Coactivator_Gene	Sp1 Activation Cofactor Gene	Sp1 Activation Cofactor Genes encode (at least 9) protein subunits of the CRSP (Cofactor Required for SP1 activation) complex, which, along with TFIID, is required for efficient activation of gene transcription by SP1, a transcription factor that recognizes enhancer sites in target DNA. Many CRSP complex proteins are also components of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins that interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. (NCI)
C20687	CRSP3_Gene	Sp1_Activation_Cofactor_Gene	CRSP3 Gene|CRSP130|CRSP133|CRSP3|Cofactor Required for Sp1 Transcriptional Activation, Subunit 3, 130kDa Gene|DRIP130|SUR2	Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation) along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP3 gene encodes a 130-kD protein that is a subunit of the CRSP complex. The CRSP3 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. The CRSp3 gene is located at chromosome 6q22.33-q24.1 on the long arm of chromosome 6. (from OMIM 605042, LocusLink 9439)
C20688	CRSP6_Gene	Sp1_Activation_Cofactor_Gene	CRSP6 Gene|CRSP6|CRSP77|Cofactor Required for Sp1 Transcriptional Activation, Subunit 6, 77kDa Gene|DRIP80|TRAP80	Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. CRSP (cofactor required for SP1 activation), along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD and 9 polypeptides have been identified as CRSP subunits. The CRSP6 gene encodes a 77-kD protein that is a subunit of the CRSP complex. The CRSP6 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. The CRSP6 gene is ubiquitously expressed as an approximately 3.0-kb transcript. The CRSP6 gene is located at chromosome 11q14 on the long arm of chromosome 11. (from OMIM 603810, LocusLink 9440)
C20689	CRSP7_Gene	Sp1_Activation_Cofactor_Gene	CRSP7 Gene|CRSP7|CRSP70|Cofactor Required for Sp1 Transcriptional Activation, Subunit 7, 70kDa Gene	Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP7 gene encodes a 70-kD protein that is a subunit of the CRSP complex. The CRSP7 protein is required for Sp1-mediated transcriptional activation with TAF(II)s. It amino terminus is similar to elongation factor TFIIS. The CRSP7 gene is located at chromosome 19p13.12 on the short arm of chromosome 19. (from OMIM 605043, LocusLink 9441)
C20690	CRSP8_Gene	Sp1_Activation_Cofactor_Gene	CRSP8 Gene|CRAP34|CRSP34|CRSP8|Cofactor Required for Sp1 Transcriptional Activation, Subunit 8, 34kDa Gene	Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP8 gene encodes a 34-kD protein that is a subunit of the CRSP complex. The CRSP protein is required for Sp1-mediated transcriptional activation with TAF(II)s. The CRSP8 gene is located at chromosome 9q34.3 on the long arm of chromosome 9. (from OMIM 605044, LocusLink 9442)
C20691	CRSP9_Gene	Sp1_Activation_Cofactor_Gene	CRSP9 Gene|CRSP33|CRSP9|Cofactor Required for Sp1 Transcriptional Activation, Subunit 9, 33kDa Gene	Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD and 9 polypeptides have been identified as CRSP subunits. The CRSP9 gene encodes a 33-kD protein that is a subunit of the CRSP complex. The CRSP9 protein is required with the TAF(II)s for Sp1-mediated transcriptional activation. The CRSP9 gene is located at chromosome 5q33.2 on the long arm of chromosome 5. (from OMIM 605045, LocusLink 9443)
C20692	Nuclear_Receptor_Coactivator_Gene	Transcription_Coactivator_Gene	Nuclear Receptor Coactivator Gene	Nuclear receptor coactivator genes encode a class of proteins that are recruited and serve as bridging molecules between the transcription initiation complex and nuclear receptors (NRs). Most of these coactivators interact with the AF-2 domain of NRs through one or several LXXLL motifs called NR box. Members of NRs includes the 5 steroid receptors and class II nuclear receptors. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation. (NCI)
C20693	Cytokeratin	Intermediate_Filament_Protein	Cytokeratin|Keratin	Cytokeratins are a family of cysteine-rich fibrous structural proteins that form tough filaments or sheets. These proteins are the main component of intermediate filaments in the epidermis, hair, nails, horny tissues, and the organic matrix of tooth enamel.
C20694	Intermediate_Filament_Protein	Cytoskeletal_Protein	Intermediate Filament Protein|IFP	Encoded by Intermediate Filament Genes, diverse Intermediate Filament Proteins (including keratin filaments, neurofilaments, desmin, and vimentin) form polymeric structural cytoplasmic filaments, intermediate in diameter (8-10 nanometer) between actin microfilaments and microtubules, that comprise part of the cytoskeleton of most eukaryotic cells. (NCI)
C20695	NCOA1_Gene	Nuclear_Receptor_Coactivator_Gene	NCOA1 Gene|F-SRC-1|NCOA1|NCoA-1|Nuclear Receptor Coactivator 1 Gene|SRC1	The NCOA1 gene at 2p23 encodes a 160-kD protein that is a coactivator required for full transcriptional activity of the steroid receptor superfamily. NCOA1 enhances the transcriptional activity of hormone-bound progesterone receptor (PGR), estrogen receptor (ESR), glucocorticoid receptor (GRL), thyroid hormone receptor, and retinoid X receptor but does not alter the basal activity of the target promoter. It is a limiting factor for efficient PGR and ESR transactivation. NCOA1 binds to TBP and to TFIIB and bridges between nuclear hormone receptors and general transcription factors. NCOA1 is involved in both chromatin remodeling and the process of recruitment/stabilization of general transcription factors and can enhance the transcriptional activities of SP1. Three mRNA splicing variants encode 3 isoforms: SRC1, SRC1E, and SRC1(-Q). SRC1E mRNA is more abundantly expressed than SRC1 or SRC1(-Q) mRNAs in all tested cell lines. (NCI)
C20696	Other_Evaluation_of_Risk_Factors	Evaluation_of_Risk_Factors	Other Evaluation of Risk Factors
C20697	NCOA2_Gene	Nuclear_Receptor_Coactivator_Gene	NCOA2 Gene|GRIP1|NCOA2|Nuclear Receptor Coactivator 2 Gene|TIF2	Involved in cell growth, development, and homeostasis, 292-kb human NCOA2 Gene at 8q13.2 encodes 1464-aa 159-kD transcriptional coactivator TIF2, containing N-terminal bHLH and PAS dimerization domains. Present in a complex with NCOA3, IKKA/B, IKBKG, and CREBBP histone acetyltransferase, TIF2 interacts with HIF1A, APEX, NR3C1, and perhaps NR3C2. TIF2 coactivator interacts with steroid receptor superfamily hormone binding domains in a hormone-dependent manner. Recruitment of CBP/p300 and PCAF coactivators for myogenic MYOD and MEF2 expression depends on NCOA1, NCOA2, and NCOA3. NCOA2 is also required for expression of MYOG and CDKN1A, and for myogenic differentiation. The NCOA2 bHLH/PAS and C-terminal activation domains mediate coactivation of MEF2C through its MADS box. The NCOA2 N- and C-termini interact with MYOG. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C20698	Breast_Cancer_Early_Detection	Early_Detection	Breast Cancer Early Detection|Early Detection of Breast Cancer	Use of a device, marker, or other means for the purpose of detecting the presence of a breast tumor early in its development.
C20699	NCOA3_Gene	Nuclear_Receptor_Coactivator_Gene	NCOA3 Gene|ACTR|AIB1|CAGH16|CTG26|NCOA3|Nuclear Receptor Coactivator 3 Gene|RAC3|TNRC14|TNRC16|TRAM-1|p/CIP	The NCOA3 gene at 20q12 encodes a 160-kD nuclear receptor coactivator. The NCOA3 protein enhances the transactivation activities of nuclear receptors in mammalian cells in hormone-dependent fashion. NCOA3 directly binds nuclear hormone receptors, including RAR, thyroid hormone receptor, VDR, and estrogen receptor. NCOA3 recruits CBP and PCAF, creating a multisubunit coactivator complex to allow transmission of the hormonal signal to the transcriptional machinery. NCOA3 has a basic helix-loop-helix domain in the N-terminus, at least 2 receptor-interaction domains (RIDs) in the central region, and a CBP-interaction domain (CID) and a histone acetyltransferase (HAT) domain in the C-terminus. While ubiquitously expressed in normal human tissues, NCOA3 is amplified and overexpressed in breast and ovarian cancer cell lines and in breast cancer biopsies. Altered NCOA3 expression may contribute to development of steroid-dependent cancers. (NCI)
C20700	NCOA5_Gene	Nuclear_Receptor_Coactivator_Gene	NCOA5 Gene|NCOA5|Nuclear Receptor Coactivator 5 Gene	The NCOA5 gene encodes a protein that is a coregulator for the alpha and beta estrogen receptors and the orphan nuclear receptor NR1D2. The NCOA5 protein localizes to the nucleus and has both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with other coreceptors. Two alternatively spliced transcript variants for this gene have been described. However, the full length nature of one of the variants has not been determined. The NCOA5 gene is located at chromosome 20q12-q13.12 on the long arm of chromosome 20. (from LocusLink 57727)
C20701	Alcohol_Abuse	Substance_Abuse	Alcohol Abuse	Alcohol Abuse; the use of alcoholic beverages to excess, either on individual occasions ("binge drinking") or as a regular practice.
C20702	NCOA6_Gene	Nuclear_Receptor_Coactivator_Gene	NCOA6 Gene|ASC2|KIAA0181|NCOA6|NRC|Nuclear Receptor Coactivator 6 Gene|PRIP|RAP250|TRBP	Nuclear hormone receptors activate gene transcription through ligand-dependent association with coactivators. The NCOA6 gene at 20q11 encodes a 250-kD protein that is a nuclear receptor coactivator. NCOA6 interacts with multiple members of the nuclear receptor family, including THRB and estrogen receptor. The first copy of the two LXXLL domains in the NCOA6 protein is functional in ligand-dependent interaction with the AF2 domain of nuclear receptors and mutation of this sequence abolishes transcriptional enhancement. NCOA6 strongly transactivates through THRB and estrogen receptor in a dose-related and ligand-dependent manner. Increased NCOA6 copy number is found in 10% of breast cancer specimens and in all breast cancer cell lines. NCOA6 is widely expressed with highest expression in brain and reproduction organs, such as ovary, testis, and prostate. (from OMIM 605299, PMID 10681503)
C20703	Transcription_Corepressor_Gene	Transcription_Coregulator_Gene	Transcription Repressor/Corepressor Gene|Transcription Corepressor Gene	RNA polymerase II transcription of Class II genes involves the TFIID transcription complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIIE, TFIIF, TFIIG/J, and TFIIH, as well as gene-specific factors that include TAFs, which interact with regulatory protein activation domains to enhance transcription. Transcription Corepressor Genes encode a group of transcriptional repressor/co-repressor factors that suppress transcription by binding to the operator. (NCI)
C20704	NRIP1_Gene	Transcription_Coactivator_Gene	NRIP1 Gene|NRIP1|Nuclear Receptor Interacting Protein 1 Gene|RIP140	Nuclear receptor interacting protein 1 (NRIP1) is a nuclear protein that specifically interacts with the hormone-dependent activation domain AF2 of nuclear receptors. Also known as RIP140, this protein modulates transcriptional activity of the estrogen receptor. (LocusLink)
C20705	MHC_Class-II_Protein	Immunoprotein	MHC Class II Protein|Class II MHC Protein|Histocompatibility Antigen, Class II|MHC Class II Molecule|Major Histocompatibility Complex Class II	MHC Class-II Proteins are non-covalently linked polymorphic alpha/beta transmembrane glycoproteins. The immunological function of MHC Class-II proteins is to bind and present antigenic peptides on the surfaces of cells for recognition by the antigen-specific T cell receptors of lymphocytes. These proteins plays an important role in the mediation of immune response.
C20706	MHC_Class-I_Protein	Immunoprotein	MHC Class I Protein|Class I MHC Protein|Complex Class 1|Histocompatibility Antigen, Class I|MHC Class I Molecule|Major Histocompatibility Complex Class 1	Found on virtually every cell, MHC (Major Histocompatibility, HLA) Class-I (Antigens) Proteins consist of noncovalently bound polymorphic 44-kDa MHC membrane glycoprotein and nonpolymorphic 12-kDa b2-microglobulin. The HLA antigens are encoded by closely linked multiallelic genes of the HLA (MHC) complex, a region containing several genetic loci (HLA-A, -B, -C, -DP, -DQ, -DR, -MB, -MT, and -Te).
C20707	NR0B2_Gene	Orphan_Nuclear_Receptor_Gene|Transcription_Corepressor_Gene	NR0B2 Gene|NR0B2|Nuclear Receptor Subfamily 0, Group B, Member 2 Gene|SHP|SHP1	The SHP gene at 1p36.1 encodes a protein that interacts with some members of the nuclear hormone receptor superfamily, including retinoid receptors RAR and RXR, thyroid hormone receptor, and the orphan receptor MB67. The SHP protein contains the ligand-binding and dimerization domains found in other superfamily members but lacks the conserved DNA-binding domain. SHP specifically inhibits transactivation by the superfamily members with which it interacts as a negative regulator of receptor-dependent signaling pathways. The SHP mutations result in the loss of SHP activity and are associated with early-onset mild obesity. A 1.3-kb SHP transcript is detected in human liver with lower levels of expression in heart and pancreas. SPH expression is detected in adult small intestine, adult spleen, fetal liver, and fetal adrenal gland of human tissues. (from OMIM 604630)
C20708	Orphan_Nuclear_Receptor_Gene	Nuclear_Receptor_Gene	Orphan Nuclear Receptor Gene	Orphan Nuclear Receptor Genes (NR Superfamily) encode numerous Orphan Nuclear Receptor (NRs) transcription factors thought to be activated by as yet unknown ligands. Transducing cellular signals into gene transcription, NRs regulate development, pattern formation, cell proliferation, cell differentiation, and homeostasis in target tissues. NRs share a common organization: an (N) modulatory domain, a conserved central Cys-rich region of two C4 zinc fingers that bind to specific upstream ligand-responsive target DNA elements, and a (C) ligand-binding domain. Stabilizing hydrophobic zinc finger interactions contribute to DNA binding specificity, homodimerization, and interaction with other proteins. Ligand-bound NR conformation allows coactivator interaction with the ligand-binding domain that mediates interaction with heat shock proteins, cyclophilins, and ligand. (NCI)
C20709	Nuclear_Receptor_Gene	Receptor_Gene	Nuclear Receptor Gene	Nuclear Receptor Genes (NR Superfamily) encode over 300 ligand-dependent Nuclear Receptor (NRs) transcription factors: steroid, retinoid, vitamin D, TH, and orphan receptors (unknown ligands). Transducing hormone signals into gene transcription, NRs regulate development, pattern formation, cell proliferation, cell differentiation, and homeostasis in target tissues. NRs share a common organization: an (N) modulatory domain, a conserved central Cys-rich region of two C4 zinc fingers that bind to specific upstream ligand-responsive target DNA elements, and a (C) ligand-binding domain. Stabilizing hydrophobic zinc finger interactions contribute to DNA binding specificity, homodimerization, and interaction with other proteins. Ligand-bound NR conformation allows coactivator interaction with the hormone-binding domain that mediates interaction with heat shock proteins, cyclophilins, and hormone. (NCI)
C20710	Transcription_Coregulator_Gene	Regulatory_Gene	Transcription Coregulator Gene|Transcription Coactivator/Corepressor Gene|Transcriptional Coregulator Gene	RNA polymerase II transcription of Class II genes involves the TFIID transcription complex comprised of general factors, including TBP, TFIIA, TFIIB, TFIIE, TFIIF, TFIIG/J, and TFIIH, as well as gene-specific factors that include TAFs, which interact with regulatory protein activation domains to enhance transcription. A second group of cofactors includes PC1, PC2, and PC3, which have a strong positive influence on transcription. A third group of factors suppress transcription. The combined action of general and gene-specific regulators encoded by transcription coactivator genes determines appropriate gene expression. (NCI)
C20711	SP1_Gene	Transcription_Factor_Gene	SP1 Gene|SP1|Sp1 Transcription Factor Gene|Transcription Factor Sp1 Gene	The Sp1 gene encodes a DNA-binding protein that is a member of the Sp-family of zinc-finger transcription activators. The Sp1 protein interacts with a variety of cellular and viral promoters containing GC-box elements. Profound changes in patterns of gene expression can result from relatively small changes in the concentrations of sequence-specific transcription factors. Synergistic interaction occurs between factors bound to different sites within a transcriptional control region. Sp1 has contiguous zinc finger motifs and requires zinc for sequence-specific binding to DNA. The SP1 gene is located at chromosome 12q13.1 on the long arm of chromosome 12. (from OMIM 189906, LocusLink 6667)
C20712	CRSP4_Gene	Sp1_Activation_Cofactor_Gene	CRSP4 Gene|CRSP100|CRSP4|Cofactor Required for Sp1 Transcriptional Activation, Subunit 4, 100kDa Gene	Human CRSP4 Gene, chromosome location unknown, encodes the 100-kD subunit 4 protein of the CRSP (Cofactor Required for SP1 activation) complex, which, along with TFIID, is required for efficient activation of gene transcription by SP1, a transcription factor that recognizes enhancer sites in target DNA. Many CRSP complex proteins are also components of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins that interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. (NCI)
C20713	Autoantigen_Gene	Retired_Concepts	Autoantigen Gene
C20714	AMPH_Gene	Regulatory_Gene	AMPH Gene|AMPH|AMPH1|Amphiphysin (Stiff-Man Syndrome with Breast Cancer 128kDa Autoantigen) Gene|Amphiphysin Gene	Human AMPH Gene (Amphiphysin Family) at 7p14-p13 is expressed in neurons, certain endocrine cells, and spermatocytes. Alternatively spliced Amphiphysin isoforms of 128- and 108 kD are produced that may regulate synaptic and endocrine exocytosis. Heterodimeric with AMPHL, AMPH is a non-intrinsic acidic membrane protein concentrated in nerve terminals and associated with the cytoplasmic face of synaptic vesicles. The N- and C-termini are highly conserved between chicken and human; the C-terminal region contains an SH3 domain. AMPH may control membrane associated cytoskeleton properties and protein dysfunction is associated with Stiff-Man Syndrome. (from LocusLink 273, Swiss-Prot P49418, OMIM 600418, and NCI)
C20715	BARD1_Gene	Apoptosis_Regulation_Gene	BARD1 Gene|BARD-1|BARD1|BRCA1 Associated RING Domain 1 Gene	Human BARD1 Gene at 2q34-q35 encodes nuclear BARD-1 Protein containing RING-type zinc finger, ANK repeats, and BRCT domains. The BARD-1 N-terminus heterodimerizes with BRCA1. BARD1/CSTF1 complex interacts with RNA Polymerase-2, which may inhibit pre-mRNA cleavage or polyadenylation. BARD-1 may be a part of the RNA Polymerase-2 holoenzyme that senses DNA damage; inhibition by CSTF1 may prevent erroneous polyadenylation at such sites. BARD-1 may mediate apoptosis and is processed during apoptosis. BARD-1 homodimer is more susceptible to proteolysis than BARD1/BRCA1. BARD-1 co-localizes in S phase with BRCA1 in subnuclear foci. BARD1/BRCA1 disrupted by tumorigenic Brca1-amino acid substitutions; BARD1/BRCA1 may be essential to BRCA1 tumor suppression. BARD1 defects occur in primary breast, ovarian, and uterine cancers. (from Swiss-Prot Q99728, OMIM 601593, and NCI)
C20716	Serine_Hydrolase_Gene	Hydrolase_Gene	Serine Hydrolase Gene	The serine hydrolase genes encode a functional class of hydrolytic enzymes that contain a serine residue in their active site. The serine hydrolases can be grouped into subfamilies that contain closely related members in terms of substrate specificity or amino acid sequence similarity. (from OMIM 603156)
C20717	BPHL_Gene	Serine_Hydrolase_Gene	BPHL Gene|BPHL|Biphenyl Hydrolase-Like (Serine Hydrolase; Breast Epithelial Mucin-Associated Antigen) Gene|Bph-rp|MCNAA	Human BPHL Gene (Serine Hydrolase Family) at 6p25 spans approximately 30 kb with eight exons that encode a 30 kD 274-amino acid Biphenyl Hydrolase-Related Protein, with a putative role in detoxification processes and structurally similar to enzymes involved in degradation of aromatic compounds. A major 1.8 kb BPHL transcript is expressed, with highest levels in liver and kidney; a minor 2.4 kb transcript is also expressed. Serine hydrolases contain serine in their active site and are grouped into subfamilies in terms of substrate specificity or amino acid sequence. (from Swiss-Prot Q00306, OMIM 603156, and NCI)
C20718	DDR1_Gene	Receptor_Tyrosine_Kinase_Gene	DDR1 Gene|CAK|DDR|DDR1|Discoidin Domain Receptor Family, Member 1 Gene|EDDR1|NEP|NTRK4|PTK3 Homolog|RTK6|TRKE	Homolog of mouse Ptk3, human DDR1 Gene (Insulin Receptor Family) at 6p21.3, near D6S478 and HLA class I genes, is composed of seventeen exons spanning 9 kb; expression is activated by p53. Alternative isoforms CAK I and II differ by 37 residues. Type I membrane protein DDR1 expression occurs in kidney, lung, GI tract, and brain epithelia. DDR1 exhibits extracellular Discoidin I motifs; putative ligand-binding GLY/PRO-rich domains; a F5/8 type C domain; and a N-terminal factor VIII-like domain. The C-terminal catalytic domain has type II receptor tyrosine kinase motifs. Neurotrophin TRKs 1-3 regulate development and survival of specific neuronal lineages. Activated by type I-VI collagens, NTRK4 may be a non-neuronal receptor for a NGF or involved in cell-cell interactions or cell adhesion. DDR1 is over-expressed in breast, ovarian, esophageal, and pediatric brain tumors. (from Swiss-Prot Q08345 and NCI)
C20719	Receptor_Tyrosine_Kinase_Gene	Receptor_Gene	Receptor Tyrosine Kinase Gene	Tyrosine kinase receptors (TRKs) are a family of genes encoding neurotrophin receptors that include trkA, trkB, and trkC, which are related to development, differentiation, and survival of neural crest-derived neurons and central cholinergic neurons in normal tissue. The genes encoding trkA, trkB, and trkC are designated NTRK1, NTRK2, and NTRK3 and map to chromosomes 1, 9, and 15, respectively. A member of the TRK gene family, trkE, encodes a non-neuronal receptor for nerve growth factor. (from OMIM 600408)
C20720	CDH3_Gene	Cell_Adhesion_Molecule_Gene	CDH3 Gene|CDH3|CDHP|Cadherin 3, Type 1, P-Cadherin (Placental) Gene|HJMD|PCAD	Similar to murine Cdh3, human CDH3 Gene (CDH Family) at 16q22.1 encodes Placental Cadherin, a homophilic Ca2+-dependent cell-cell adhesion type I membrane glycoprotein. Comprised of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail, the encoded protein may contribute to sorting of heterogeneous cell types. The gene is located in a six-cadherin cluster region involved in loss of heterozygosity in breast and prostate cancer. Aberrant expression is observed in cervical adenocarcinomas. Hypotrichosis with juvenile macular dystrophy is caused by homozygous deletion of an exon 8 guanine nucleotide that introduces a premature downstream termination codon. Mutant expression is reduced in the skin. (from SWISS-PROT P22223, OMIM 114021, and NCI)
C20721	Cell_Adhesion_Receptor_Gene	Receptor_Gene	Cell Adhesion Receptor Gene	A Cell Adhesion Receptor Gene encodes one of the diverse cell surface proteins that interact with extracellular ligands and initiate signal transduction pathways that mediate cell-cell and cell-extracellular matrix adhesion, recognition, activation, tissue integration, wound healing, morphogenesis, cellular migration, and metastasis.
C20722	CDH5_Gene	Cell_Adhesion_Molecule_Gene	CDH5 Gene|7B4|CDH5|Cadherin 5, Type 2, VE-Cadherin (Vascular Epithelium) Gene	Human CDH5 Gene (CDH Family) at 16q22.1 encodes VE-Cadherin, a type I membrane Ca2+-dependent homophilic endothelial cell-cell adhesion glycoprotein. It is comprised of five extracellular cadherin repeats, a transmembrane region, and a conserved cytoplasmic tail. Expressed in endothelial cells and brain, CDH5 is found at cell-cell boundaries and probably at cell-matrix boundaries. Associated with intercellular junctions, CDH5 may play an important role in endothelial cell cohesion and organization of intercellular junctions. CDH5/beta-catenin signaling may control endothelial survival. CDH5 associates with alpha-catenin, forming a link to the cytoskeleton. Including CDH1, CDH3, CDH8, and CDH11, CDH5 is located in a six-cadherin cluster region involved in loss of heterozygosity in breast and prostate cancer. (from LocusLink 1003, SWISS-PROT P33151, OMIM 601120, and NCI)
C20723	CDH13_Gene	Cell_Adhesion_Molecule_Gene	CDH13 Gene|CDH13|CDHH|Cadherin 13, H-Cadherin (Heart) Gene	Human putative breast cancer tumor suppressor CDH13 Gene (CDH Family) at 16q24.2-q24.3 encodes Cadherin 13, an 80 kD Ca2+-dependent cell-cell adhesion glycoprotein. Comprised of five extracellular cadherin repeats and attached to the membrane by a GPI-anchor, H-Cadherin lacks the highly conserved cytoplasmic region, unlike typical cadherins. Two alternative polyadenylation mRNAs encode identical proteins. Highest expression is observed in heart. CDH13 is also expressed in CNS; at higher in adult than in developing brain.  A putative mediator of heart cell interactions, this cadherin may also inhibit neural cell growth. CDH13 is expressed in normal cells, but not in most human epithelial tumor cells. The gene is hypermethylated or deleted in breast, ovarian and lung cancers. (from SWISS-PROT P55290, OMIM 601364, LocusLink 1012, and NCI)
C20724	CREBL2_Gene	Transcription_Factor_Gene	CREBL2 Gene|CREBL2|cAMP Responsive Element Binding Protein-Like 2 Gene	cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurrence of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. (LocusLink)
C20725	Cysteine_Proteinase_Inhibitor_Gene	Proteinase_Inhibitor_Gene	Cysteine Proteinase Inhibitor Gene	Human Cysteine Proteinase Inhibitor Genes encode Cysteine Proteinase Inhibitors, endogenous proteins that hinder the function of cysteine proteinases.
C20726	Cystatin_Superfamily_Gene	Cysteine_Proteinase_Inhibitor_Gene	Cystatin Superfamily Gene	Cystatin Superfamily Genes comprise a single evolutionary superfamily that encode protein subfamilies with functional and structural similarities that include cystatin-like sequences: Stefins (Type 1 Cystatins), Cystatins (Type 2 Cystatins), and Kininogens. Some members are active cysteine protease inhibitors; others have lost or never acquired inhibitory activity. Cystatins are intracellular or extracellular, tight, reversible, competitive inhibitors of lysosomal cysteine proteinases, such as Cathepsins B, L, H, and S, that appear to provide a protective function. Type 1 Cystatins lack disulfide bridges. Type 2 Cystatins are secreted and have 2 intrachain disulfide bonds. Kininogens contain 3 cystatin-like domains, each with 2 disulfide bonds. (NCI)
C20727	Cystatin_Family_Gene	Cystatin_Superfamily_Gene	Cystatin Family Gene|Cystatin 2 Family Gene	Cystatin Family Genes encode (Type 2) Cystatin proteins, secreted, tight, reversible, competitive inhibitors of cysteine proteinases that contain multiple cystatin-like sequences and have 2 intrachain disulfide bonds. Cystatin Superfamily Genes comprise three subfamilies that display structural and/or functional similarities: Stefins (Type 1 Cystatins), Cystatins (Type 2 Cystatins), and Kininogens. Some members are active cysteine protease inhibitors; others have lost or never acquired inhibitory activity. (NCI)
C20728	CST6_Gene	Stefin_Family_Gene	CST6 Gene|CST6|CSTB|Cystatin E/M Gene|STFB	Human CST6 Gene at 11q13 encodes Cystatin 6, a type 2 cystatin. Cystatin family proteins contain multiple cystatin-like sequences. Three inhibitory subfamilies display structural and functional similarities: type 1 stefins, type 2 cystatins, and kininogens. Some members are active cysteine protease inhibitors; others have lost or never acquired inhibitory activity. Type 2 cystatins are endogenous intracellular or extracellular cysteine proteinase inhibitors that appear to provide a protective function. Cystatin 6 is a novel secreted human cysteine protease inhibitor, down regulated in metastatic breast tumor cells compared to primary tumor cells. Loss of expression is likely associated with primary tumor progression to a metastatic phenotype. (from Swiss-Prot Q15828, OMIM 601891, and NCI)
C20729	Stefin_Family_Gene	Cystatin_Superfamily_Gene	Stefin Family Gene|Cystatin 1 Family Gene	One of three inhibitory families in the cystatin superfamily (including type 2 cystatins and kininogens), Stefin Family Genes (type 1 cystatins) encode intracellular cysteine thiol protease inhibitors of papain and cathepsins B, H, and L. Cystatin Superfamily proteins contain multiple cystatin-like sequences; some are active cysteine protease inhibitors, while others have lost or perhaps never acquired this activity. (NCI)
C20730	Kininogen_Family_Gene	Cystatin_Superfamily_Gene	Kininogen Family Gene	Encoding Kininogen proteins, Kininogen Family Genes belong to the Cystatin Superfamily, a single evolutionary superfamily of three inhibitory subfamilies that encode proteins with likely protective function and structural similarities that include cystatin-like sequences: Stefins (Type 1 Cystatins), Cystatins (Type 2 Cystatins), and Kininogens. Many members are active cysteine protease inhibitors; others have lost or never acquired inhibitory activity. Kininogens contain 3 cystatin-like domains, each with 2 disulfide bonds. Type 2 Cystatins contain multiple cystatin-like domains and have 2 intrachain disulfide bonds. Type 1 Cystatins contain multiple cystatin-like domains and lack disulfide bridges. (NCI)
C20731	Protein_Phosphatase_Gene	Phosphatase_Family_Gene	Protein Phosphatase Gene	Protein Phosphatase Genes encode Protein Phosphatases, enzymes that remove tyrosine-, serine-, or threonine-bound phosphate groups from many phosphoproteins, including many enzymes phosphorylated by a tyrosine kinase or a serine/threonine kinase. (NCI)
C20733	DUSP3_Gene	Protein_Phosphatase_Gene	DUSP3 Gene|DUSP3|Dual Specificity Phosphatase 3 (Vaccinia Virus Phosphatase VH1-Related) Gene|VHR	Located 100 kb proximal to D17S78 in a 400 kb region containing BRCA1, human DUSP3 Gene at 17q21 is conserved through evolution and encodes VH1-Related Phosphatase, a non-receptor member of the dual specificity protein phosphatase subfamily (Protein Tyrosine Phosphatase Family) expressed in breast and ovarian tissue. The protein inactivates target substrates by dephosphorylating phosphotyrosine and phosphoserine/threonine residues. Negative regulators of MAPK/ERKs, SAPK/JNKs, and p38s associated with proliferation and differentiation, dual specificity phosphatases show different tissue distributions and subcellular locations, distinct MAP kinase specificities, and different modes of induction by extracellular stimuli. (from LocusLink 1845, Swiss-Prot P51452, OMIM 600183, and NCI)
C20735	FABP_Family_Gene	Ligand_Binding_Protein_Gene	FABP Family Gene	These genes encode the intracellular fatty acid-binding proteins (FABPs). Fatty acid metabolism in mammalian cells depends on a flux of fatty acids, between the plasma membrane and mitochondria or peroxisomes for beta-oxidation, and between other cellular organelles for lipid synthesis. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and at least 3 different FABPs play a role as transport vehicles of these hydrophobic compounds throughout the cytoplasm. They may participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. (from LocusLink 2170)
C20736	FABP3_Gene	FABP_Family_Gene	FABP3 Gene|FABP11|FABP3|Fatty Acid Binding Protein 3, Muscle and Heart (Mammary-Derived Growth Inhibitor) Gene|Fatty Acid-Binding Protein 3 Gene|HFABP|MDGI|MDGI Gene|MFABP|O-FABP	Human FABP3 Gene (FABP/P2/CRBP/CRABP Transporter Family), an open reading frame of 399 nucleotides in four exons over 8 kb at 1p33-p31, encodes a 14-15 kD Fatty Acid-Binding Protein 3 of 133 amino acids. Cytoplasmic FABPs in liver, heart, intestine, skeletal muscle, and brain transport intracellular hydrophobic compounds involved in uptake, metabolism, or transport of long-chain fatty acids and their acyl-CoA esters. Mammalian fatty acid metabolism depends on fatty acid flux between plasma membrane and mitochondria or peroxisomes for beta-oxidation and between other cellular organelles for lipid synthesis. A candidate tumor suppressor for human breast cancer, FABP3 is likely involved in intracellular fatty acid transport, arrests the growth of mammary epithelial cells, and is involved in mammary gland differentiation. (from LocusLink 2170, Swiss-Prot P05413, OMIM 134651, and NCI)
C20737	RNA_Binding	Nucleic_Acid_Binding	RNA Binding	RNA Binding is the molecular interaction between an RNA molecule and a macromolecule (usually protein or nucleic acid) for transport, catalysis, localization, or modification of function.
C20738	Lipid_Binding	Molecular_Interaction	Lipid Binding	Lipid Binding is the molecular interaction between a lipid molecule and a macromolecule (usually protein) for transport, catalysis, localization, or modification of function.
C20739	Lipid_Transport	Transport_Process	Lipid Transport|Lipid Trafficking	Any subcellular or molecular event, process, or condition involved in translocation of a lipid macromolecule from one site or compartment to another. (NCI)
C20740	Histone_Acetylation	Protein_Acetylation	Histone Acetylation	Histone Acetylation involves covalent linkage of acetyl groups to highly basic histone proteins associated with DNA, particularly in active chromatin, and may be involved in regulation of gene expression.
C20741	Tumor_Cell_Mobility	Tumor_Expansion	Tumor Cell Mobility	Any type of motility of a tumor cell that involves translocation of the cell, or cell body, from one site to another; distinct from forms of cell movement that involve only movement of cell processes (e.g., axons, microvilli, etc.). (NCI)
C20743	FGFR4_Gene	Receptor_Tyrosine_Kinase_Gene	FGFR4 Gene|FGFR4|Fibroblast Growth Factor Receptor 4 Gene|JTK2 Gene|TKF Gene	Human FGFR4 Gene (FGFR Family) at 5q35.1-qter, distal to DRD1, spans 11 kb with a TATA-free promoter and eighteen exons (17-600 base pairs), and encodes a type I membrane tyrosine kinase Fibroblast Growth Factor Receptor 4. Exon 1 is untranslated and short tandem repeats occur in introns 2 and 16. Highly conserved FGFR4 protein exhibits three extracellular Ig-like C2-type domains, a cytoplasmic kinase domain, and 55% amino acid identity with FLG (FGFR1) and BEK. The FGFR4 IgIII domain C-terminal half does not vary. Affecting downstream mitogenesis and differentiation cascades, FGFR members differ in ligand affinities and distribution; FGFR4 is expressed predominantly in lung. The endoderm selectively co-expresses FGFR1 and FGFR4. Although its function is unknown, FGFR4 binds acidic FGF and FGF19; it does not bind to bFGF. (from LocusLink 2264, Swiss-Prot P22455, OMIM 134935, and NCI)
C20744	Structural_Gene	Gene	Structural Gene	A gene that encodes a protein with a chief function as part of a physical structure within a cell.  This is in contrast to genes that encode proteins with a function that is enzymatic or regulatory.
C20745	Cytoskeletal_Gene	Structural_Gene	Cytoskeletal Gene	Cytoskeletal Genes encode Cytoskeletal Proteins, diverse structural proteins including polymerizable globular subunits (actin, tubulin), "motor ATPases" (myosin, dynein), membrane-supporting linkers (spectrin, clathrin), fibrous proteins (keratin, vimentin), and many more. As constituents of the cytoskeleton, Cytoskeletal Proteins form a flexible cellular framework that provides attachment points for organelles and formed bodies and makes communication between cell parts possible. (NCI)
C20746	Microfilament_Gene	Cytoskeletal_Gene	Microfilament Gene
C20747	GAS2_Gene	Microfilament_Gene	GAS2 Gene|GAS2|Growth Arrest-Specific 2 Gene	The GAS2 gene encodes a 36-kD protein that is a component of the microfilament system. GAS2 is specifically expressed at growth arrest. When expressed in mammalian cells, the human GAS2 protein is localized at the actin cytoskeleton, along the stress fibers and at the plasma membrane. GS2 is phosphorylated on serine residues during the G0-G1 transition phase. When hyperphosphorylated, GAS2 is accumulates at membrane ruffles. GAS2 plays a role in apoptosis by acting as a cell death substrate for caspases. GAS2 is proteolytically cleaved in apoptotic cells during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. GAS2 is ubiquitously expressed with highest levels in liver, lung, and kidney, but not found in spleen. The GAS2 gene is located at chromosome 11p14.3-p15.2 on the short arm of chromosome 11. (from OMIM 602835, Swiss-Prot O43903)
C20748	Regulation_of_Cell_Shape	Cell_Growth_Regulation	Regulation of Cell Shape	Intracellular or extracellular processes that control, manage, or govern adoption or maintenance of sustained or transient changes in cell shape. (NCI)
C20749	Segmental_Mastectomy	Breast_Conservation_Treatment	Segmental Mastectomy|segmental mastectomy	(mas-TEK-toe-mee) The removal of a cancer as well as some of the breast tissue around the tumor and the lining over the chest muscles below the tumor. Usually some of the lymph nodes under the arm are also taken out.  Also called partial mastectomy.
C20750	Cell_Proliferation_Regulation	Biochemical_Process	Cell Proliferation Regulation|Regulation of Cell Proliferation	Cell Proliferation Regulation involves intercellular, cellular, and subcellular mechanisms that determine when and whether cell division occurs.
C20751	Inhibition_of_Cell_Proliferation	Cell_Proliferation_Regulation	Inhibition of Cell Proliferation|Negative Control of Cell Proliferation|Negative Regulation of Cell Proliferation	Inhibition of Cell Proliferation involves intercellular, cellular, and subcellular mechanisms that inhibit or block the induction, promotion, maintenance, or completion cell division.
C20752	GAS8_Gene	Gene_with_Unknown_or_Unclassified_Function	GAS8 Gene|GAS11|GAS8|Growth Arrest-Specific 8 Gene	Human GAS8 Gene at 16q24.3 contains eleven exons spanning 25 kb that include a 1.4 kb open reading frame encoding Growth Arrest-Specific Protein 8, a 478-amino acid putative tumor suppressor protein. Two ubiquitous transcripts of 3.4 and 1.8 kb are seen, while a 7.3 kb transcript is observed in heart and skeletal muscle and a 1.4 kb transcript is observed in skeletal muscle alone. Human GAS8 amino acid sequence is 96% identical to the mouse homolog, expressed during growth arrest; the UTRs differ completely. Intron 2 contains C16ORF3, an intronless gene in the opposite orientation transcribed at low levels. GAS8 maps to a region sometimes deleted in breast and prostrate cancer. (NCI)
C20754	ACRBP_Gene	Ligand_Binding_Protein_Gene	ACRBP Gene|ACRBP|Acrosin Binding Protein Gene|OY-TES-1|SP32	Human ACRBP Gene (CT family) at 12p13.32 encodes Acrosin Binding Protein, similar to proacrosin binding protein sp32 precursor found in pig, mouse, and guinea pig.  ACRBP mRNA is expressed only in normal testis, but detected in a range of tumor types such as bladder, breast, lung, liver, and colon.  Located in the sperm acrosome, this immunogenic protein may bind to proacrosin to package and condense the zymogen in the acrosomal matrix. (from SWISS-PROT, LocusLink, and NCI)
C20755	AGR2_Gene	Gene_with_Unknown_or_Unclassified_Function	AGR2 Gene|AG2|AGR2|Anterior Gradient 2 Homolog|Anterior Gradient 2 Homolog (Xenopus Laevis) Gene|GOB-4|HAG-2|HAG-2 Gene|XAG-2|XAG-2 Gene	The AGR2 gene at 7p21.3 encodes Anterior Gradient 2 Homolog (Xenepus Laevis), a soluble, signal peptide containing protein that is 47% identical to the cement gland anterior gradient protein (Xenopus laevis). Strongest expression of the 0.9- and 1.6 kb transcripts are seen in the lung and in all estrogen receptor-positive breast carcinoma lines tested while weaker expression is detected in the pancreas and other tissues. Strong expression is also detected in trachea, stomach, colon, prostate, and small intestine. The AGR2 gene is one of seven known genes that are deleted in Wilms tumor and is a candidate suppressor gene for Wilms tumor. (From OMIM, PMID, Proteome and NCI)
C20756	ANP32C_Gene	Gene_with_Unknown_or_Unclassified_Function	ANP32C Gene|ANP32C|Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member C Gene|PP32R1	Human ANP32C Gene (PP32 family) on chromosome 4 lacks introns and encodes PP32R1, a product that shares approximately 90% amino acid sequence identity with PP32 and PP32R2.  PP32 is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers.  PP32R1 and PP32R2 are tumorigenic.  Amino acids 150-174 of PP32 are responsible for its tumor suppressor function and are a region of divergence with PP32R1.  Alternative use of PP32, PP32R1, and PP32R2 may modulate the oncogenic potential of human prostate cancer. (NCI)
C20757	HMMR_Gene	Receptor_Gene	HMMR Gene|HMMR|Hyaluronan-Mediated Motility Receptor (RHAMM) Gene|Hyaluronan-Mediated Motility Receptor Gene|IHABP|RHAMM	Human HMMR Gene at 5q33.2 encodes a 477-amino acid cell surface and cytoplasmic Hyaluronan-Mediated Motility Receptor, similar to murine Hmmr. Two alternative isoforms are expressed in normal breast tissue. The 15 kb mouse gene contains at least fourteen exons that produce alternative mRNAs. A subunit of the HARC complex, the hyaluronan receptor is required for cell motility and may regulate ERK activity. Hyaluronan receptors mediate glioma cell migration. Phosphorylation of several proteins, including pp125-FAK, occurs when hyaluronan binds HMMR. FAK phosphorylation is necessary for disassembly of focal contacts and motility. RHAMM is up regulated in response to wound healing. Although no correlation is observed between the level of expression and metastatic or malignant potential, HMMR may be involved in transformation and metastasis. (from Swiss-Prot O75330, OMIM 600936, and NCI)
C20758	Hyaluronic_Acid_Binding	Protein-Carbohydrate_Interaction	Hyaluronic Acid Binding	Hyaluronic Acid Binding involves a biophysical interaction between a biological molecule, such as a protein, and hyaluronic acid, a linear glycosaminoglycan of repeating disaccharide units, in proteoglycans.
C20759	ANP32D_Gene	Gene_with_Unknown_or_Unclassified_Function	ANP32D Gene|ANP32D|Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member D Gene|PP32R2	Human ANP32D Gene (PP32 family) on chromosome 12 lacks introns and encodes PP32R2, a product that shares approximately 90% amino acid sequence identity with PP32 and PP32R1.  PP32 is a tumor suppressor that can inhibit several types of cancers, including prostate and breast cancers.  PP32R2 and PP32R1 are tumorigenic. Amino acids 150-174 of PP32 are responsible for its tumor suppressor function and are a region of divergence with PP32R1. Alternative use of PP32, PP32R1, and PP32R2 may modulate the oncogenic potential of human prostate cancer.  PP32R2 is expressed in prostate cancer. (NCI)
C20760	APPBP2_Gene	Transport_Protein_Gene	APPBP2 Gene|APPBP2|Amyloid Beta Precursor Protein (Cytoplasmic Tail) Binding Protein 2 Gene|PAT1	Human APPBP2 Gene on chromosome 17 expresses a ubiquitous 6.5 kb transcript with multiple polyadenylation sites encoding 70 kD cytoplasmic Amyloid Beta Precursor Protein-Binding Protein 2. APPBP2 contains terminal globular structures, a coiled coil domain, PKC phosphorylation sites, and four imperfect C-terminal tandem repeats. In the Golgi apparatus, APPBP2 is associated with transport or processing of the signal-transducing amyloid precursor protein (APP). Cell surface sorting of APP depends on a tyrosine-based cytoplasmic basolateral sorting signal (BaSS) sequence to which APPBP2 specifically binds. Amyloid BaSS tyrosine mutation prevents APPBP2 binding and results in nonpolarized transport. Similar to the kinesin light chain, APPBP2 also interacts with microtubules and may have a role in vesicle sorting.  (from OMIM, Proteome, and NCI)
C20761	ARHI_Gene	G_Protein_Gene	ARHI Gene|ARHI|NOEY2|RAS Homolog Gene Family, Member I	Human ARHI Gene (RHO family) at 1p31 contains two exons that encode a 1.9 kb transcript expressed in breast and ovarian epithelial cells, and in heart, liver, pancreas, and brain; expression is absent in breast and ovarian cancer cell lines.  Maternally imprinted ARHI is expressed monoallelically and associated with growth suppression; it appears to be a tumor suppressor gene.  Growth factors decrease expression of ARHI, as does WAF1 (CDKN1A).  The 26 kD 229 amino acid RHO-Related GTP-Binding Protein RHOI shares 54% amino acid homology with HRAS and 56-62% homology with RAS-related proteins.  ARHI contains a highly conserved GTP-binding domain, a putative effector domain distinct from that of RAS and RAP proteins, and a C-terminal membrane localization motif.  (from SWISS-PROT, OMIM, Proteome, and NCI)
C20762	Metastasis_Suppressor_Gene	Cancer_Gene	Metastasis Suppressor Gene	Metastasis Suppressor Genes encode Metastasis Suppressors, proteins involved in inhibition of tumor cell metastasis. (NCI)
C20763	AXIN2_Gene	Signaling_Pathway_Gene	AXIN2 Gene|AXIL|AXIN2	Single copy, 25 kb human AXIN2 Gene at 17q24 contains ten exons encoding a 3.0 kb transcript translated into ubiquitous cytoplasmic Conductin, a beta-catenin protein stability regulator inhibiting the WNT pathway. AXIN2 contains DIX, RGS-signaling, GSK-binding, beta-catenin-binding, and DSH domains.  Mouse conductin organizes an APC/beta-catenin/GSK3B complex that promotes beta-catenin degradation. Conductin may facilitate phosphorylation of APC and beta-catenin by GSK3B. Armadillo repeats mediate interaction with beta-catenin. GSK3B may phosphorylate AXIN2, likely dephosphorylated by PP2A. Colorectal cancer associated with MMR gene alterations result in AXIN2 mutations, stabilization of beta-catenin, and activation of beta-catenin/TCF signaling. (from SWISS-PROT, OMIM, Proteome, and NCI)
C20764	Metastasis_Suppression	Cell_Migration_Inhibition	Metastasis Suppression|Suppression of Metastasis	Metastasis Suppression involves interference or restraint of the spread or migration of cancer cells from one part of the body (the organ in which it first appeared) to another. The secondary tumor contains cells that are like those in the original (primary) tumor (NCI)
C20765	KISS1_Gene	Gene_with_Unknown_or_Unclassified_Function	KISS1 Gene|KISS1|KiSS-1|KiSS-1 Metastasis-Suppressor Gene|MGC39258	Human KISS1 Gene at 1q32 encodes a 145-amino acid KISS1 Metastasis Suppressor Protein that may regulate events downstream of cell-matrix adhesion, perhaps involving cytoskeletal reorganization.  KISS1 is expressed as a 1 kb mRNA in normal placenta tissue and as smaller transcripts at low levels in pancreas and kidney.  KISS1 may suppress metastasis without affecting tumorigenicity.  Placental Metastin, a truncated C-terminally amidated peptide form of KISS1, with 54 amino acid residues, is an endogenous ligand of orphan GPR54 (a GPCR) and appears to inhibit chemotaxis and metastasis. (NCI)
C20766	BAP1_Gene	Ligand_Binding_Protein_Gene	BAP1 Gene|BAP1|BRCA1 Associated Protein-1 (Ubiquitin Carboxy-Terminal Hydrolase) Gene|HUCEP-13|HUCEP-6|KIAA0272	Human BAP1 Gene at 3p21.3 is ubiquitously expressed as a 4 kb mRNA; plus a 4.8 kb transcript in the testis. The encoded 729-amino acid nuclear BRCA1 Associated Protein-1 contains an acidic region, a highly charged C-terminus, and putative nuclear localization signals. The N-terminus shows homology to ubiquitin C-terminal hydrolases, thiol proteases that catalyze ubiquitin proteolytic processing. Murine BAP1 and BRCA1 are co-expressed during breast development and remodeling. BAP1 interacts with the BRCA1 RING finger, prevented by RING finger germline mutations. BAP1 may be a tumor suppressor in the BRCA1 growth control pathway and enhances BRCA1 inhibition of breast cancer cell growth.  Homozygous BAP1 intragenic rearrangements and deletions occur in lung carcinoma. (from SWISS-PROT, OMIM, Proteome, and NCI)
C20767	BCAR1_Gene	Adaptor_Signaling_Protein_Gene	BCAR1 Gene|BCAR1|Breast Cancer Anti-Estrogen Resistance 1 Gene|CAS|CRKAS	Ubiquitously expressed 25 kb human BCAR1 Gene (CAS Family) at 16q23.1 contains multiple 5-prime CpG islands and seven exons encoding a 3.2 kb transcript for a 116 kD 870-amino acid p130CAS docking/adaptor molecule. CAS contains a Ser-region, a NH-SH3 domain, a central YXXP motif SH2-binding site substrate domain, SRC SH3-binding site COOH Pro-rich binding region, and C-terminal HLH. CAS functions in embryogenesis, cardiovascular development, actin assembly, and cytoskeletal organization. CAS is tyrosine-phosphorylated in SRC-activated cells and involved in cell adhesion, cell migration, growth factor stimulation, and cytokine receptor engagement. CAS and FAK may function in actin assembly and growth from focal adhesions. CAS over expression confers anti-estrogen resistance to breast cancer cells. (from SWISS-PROT, OMIM, Proteome, and NCI)
C20768	Cytoskeletal_Modeling	Cytoskeleton_Alteration	Cytoskeletal Modeling|Cytoskeletal Organization|Cytoskeletal Organization Process|Cytoskeletal Reorganization	Subcellular biological functions, activities, or processes that generate, maintain, or modify macromolecular cytoskeletal components. (NCI)
C20769	BCAR2_Gene	Gene_with_Unknown_or_Unclassified_Function	BCAR2 Gene|BCAR2|Breast Cancer Anti-Estrogen Resistance 2 Gene	Alteration of human BCAR2 Gene, which encodes a protein similar to gamma-butyrobetaine 2-oxoglutarate dioxygenase (C. elegans, Drosophila), is likely responsible for development of an anti-estrogen-resistant phenotype. (from Int J Cancer. 1997; 72:700, LocusLink, GeneCard, and NCI)
C20770	BCAR3_Gene	Gene_with_Unknown_or_Unclassified_Function	BCAR3 Gene|BCAR3|Breast Cancer Anti-Estrogen Resistance 3 Gene|NSP2|SH2D3B	Human BCAR3 Gene encodes a 92 kD 825-amino acid protein that contains a putative SH2 domain, a hallmark of tyrosine kinase signaling molecules, and sequences homologous to CDC48 (Yeast).  Abundant expression of a 3.4 kb transcript is seen in heart, placenta, skeletal muscle, spleen, prostate, testis, ovary, small intestine, colon, fetal kidney, and several cancer cell lines, but not in nonmalignant breast tissue.  A 6 kb transcript is also detected in skeletal muscle and heart.  NSP2 induces anti-estrogen resistance in estrogen-dependent breast tumors.  (from SWISS-PROT, OMIM, Proteome, and NCI)
C20771	BCAS1_Gene	Gene_with_Unknown_or_Unclassified_Function	BCAS1 Gene|AIBC1|BCAS1|Breast Carcinoma Amplified Sequence 1|Breast Carcinoma Amplified Sequence 1 Gene|NABC1	Human BCAS1 Gene at 20q13.2 encodes a predicted 585 amino acid protein with no significant homology to other proteins and of unknown function that is over expressed in most but not all breast cancer cell lines in which the gene is amplified.  Region 20q13 is amplified in a variety of tumor types and is associated with more aggressive tumor phenotypes.  However, the BCAS1 gene is not located within the common region of maximal amplification in 20q13 and its expression is not detected in the breast cancer cell line MCF7, in which this region is highly amplified.  Although not consistently expressed in breast cancer cell lines, BCAS1 is a candidate oncogene.  (from SWISS-PROT, OMIM, Proteome, and NCI)
C20772	BCAS2_Gene	Gene_with_Unknown_or_Unclassified_Function	BCAS2 Gene|BCAS2|Breast Carcinoma Amplified Sequence 2|Breast Carcinoma Amplified Sequence 2 Gene|DAM1	Human BCAS2 Gene at 1p21-p13.3 encodes a 225 amino acid protein that contains a central putative N-glycosylation site and multiple N-terminal putative phosphorylation sites.  BCAS2 is ubiquitously expressed in normal tissues; a 1.5 kb transcript is expressed in many breast cancer cell lines, with greatest amplification in BT-20 and MCF-7 cells.  A sequence identical to BCAS2 is seen in Putative Spliceosome-Associated Protein SPF27.  (from OMIM, Proteome, and NCI)
C20773	BCAS3_Gene	Gene_with_Unknown_or_Unclassified_Function	BCAS3 Gene|BCAS3|Breast Carcinoma Amplified Sequence 3|Breast Carcinoma Amplified Sequence 3 Gene	Human BCAS3 Gene at 17q23 encodes a protein of unknown function.  (from SWISS-PROT, LocusLink, and NCI)
C20774	BCAS4_Gene	Gene_with_Unknown_or_Unclassified_Function	BCAS4 Gene|BCAS4|Breast Carcinoma Amplified Sequence 4|Breast Carcinoma Amplified Sequence 4 Gene	Associated with markers RH65330 and SHGC-64933, human BCAS4 Gene at 20q13.13 encodes a protein of unknown function with high similarity to a region of MAP4K1 and similarity to metalloendopeptidase (Drosophila).  Spanning more than 81 kb, BCAS4 is expressed in brain, heart, liver, pancreas, prostate, kidney, and lung.  (from SWISS-PROT, LocusLink, and NCI)
C20775	BRCD1_Gene	Gene_with_Unknown_or_Unclassified_Function	BRCD1 Gene|BCDS1|BRCD1|Breast Cancer, Ductal, Suppressor-1|Breast Cancer, Ductal, Suppressor-1 Gene	A yet uncharacterized human gene of unknown function, on chromosome 13, and associated with breast cancer. (from LocusLink, OMIM, and NCI)
C20776	BCPR_Gene	Gene_with_Unknown_or_Unclassified_Function	BCPR Gene|BCPR|Breast Cancer-Related Regulator of TP53 Gene	Defined by D17S926, D17S695, and D17S849, which map close together in a region of high loss of heterozygosity (60%), human BCPR Gene at 17p13.3 appears to be associated with over expression of p53 mRNA, suggesting a gene located some twenty megabases telomeric to TP53 that regulates its expression.  Lesions of this regulatory gene seem to be involved in most breast cancers. (from OMIM and NCI)
C20778	BC-2_Gene	Gene_with_Unknown_or_Unclassified_Function	CHMP2A Gene|BC-2|BC-2 Gene|Chromatin Modifying Protein 2A Gene	Human BC-2 Gene at 19q encodes a protein of unknown function with low similarity to Vps24p (S. cerevisiae). (from SWISS-PROT, LocusLink, and NCI)
C20779	BRCA3_Gene	Gene_with_Unknown_or_Unclassified_Function	BRCA3 Gene|BRCA3|BRCAX|Breast Cancer 3 Gene	A yet uncharacterized human gene at 13q21 of unknown function and associated with breast cancer. (from LocusLink, OMIM, and NCI)
C20780	NY-BR-1_Gene	Gene_with_Unknown_or_Unclassified_Function	ANKRD30A Gene|ANKRD30A|Ankyrin Repeat Domain 30A Gene|NY-BR-1|ankyrin repeat domain 30A	Spanning more than 10 kb and expressed in breast and testis, human Breast Cancer Antigen NY-BR-1 Gene at 10q11-p12 is composed of thirty-seven exons that encode an open reading frame of 4.0-4.2 kb.  The 150-160 kD NY-BR-1 Protein contains a DNA-binding bZIP motif and five tandem ankyrin repeats.  These structural features of NY-BR-1 imply a transcription factor involved in protein-protein interactions.  (from Cancer Res 2001; 61:2055, SWISS-PROT, LocusLink, and NCI)
C20781	BRMS1_Gene	Gene_with_Unknown_or_Unclassified_Function	BRMS1 Gene|BRMS1|Breast Cancer Metastasis Suppressor 1 Gene|Breast Cancer Metastasis-Suppressor 1	BRMS1 is a human breast carcinoma metastasis suppressor gene that maps to 11q13, a hotspot in breast cancer progression.[supplied by OMIM] (from LocusLink)
C20782	COX7A2L_Gene	Gene_with_Unknown_or_Unclassified_Function	COX7A2L Gene|COX7A2L|COX7AR|COX7RP|Cytochrome C Oxidase Subunit VIIa Polypeptide 2 Like Gene|EB1|SIG81	Human COX7A2L Gene (COXVIIA family) on chromosome 2 encodes a deduced 114 amino acid COX7A-Related Protein that is homologous to mouse Sig81 and contains C-terminal residues similar to polypeptides 1 and 2 of cytochrome c oxidase subunit VIIa.  Ubiquitous expression of a 1.5 kb transcript is enhanced by estrogen through a COX7A2L gene enhancer estrogen-responsive element in a CpG island.  This gene may encode a regulatory subunit of mitochondrial COX that mediates higher energy production in estrogen target cells.  (from SWISS-PROT, OMIM, Proteome, and NCI)
C20783	DLC1_Gene	Regulatory_Gene	DLC1 Gene|ARHGAP7|Deleted in Liver Cancer 1 Gene|HP|STARD12	Human DLC1 Gene at 8p22-p21.3 is deleted in hepatocellular carcinoma, and frequently in solid tumors.  A major 7.5- and a minor 4.5 kb transcript are widely expressed that encode a deduced 1,091 amino acid protein having high sequence similarity with p122RhoGap (Rat).  DLC1 is a candidate tumor suppressor gene for liver, prostate, lung, colorectal, and breast cancers. (from OMIM, Proteome, and NCI)
C20784	Epithelial_Protein_Up-Regulated_in_Carcinoma_Membrane_Associated_Protein_17_Gene	Retired_Concepts	Epithelial Protein Up-Regulated in Carcinoma, Membrane Associated Protein 17 Gene
C20785	EPSTI1_Gene	Gene_with_Unknown_or_Unclassified_Function	EPSTI1 Gene|BRESI1|EPSTI1|Epithelial Stromal Interaction 1|Epithelial Stromal Interaction 1 (Breast) Gene	Spanning more than 10 kb and expressed in prostate, kidney, and lung, human EPSTI1 Gene at 13q13.3 encodes a protein with putative epithelial stromal interaction function.  EPSTI1 is similar to G-protein coupled receptors family 1 (C. elegans) and G-protein coupled receptor protein signaling pathway growth hormone-releasing hormone receptor (Drosophila).  (from GeneCard, LocusLink, and NCI)
C20786	FBXW7_Gene	Ubiquitin_Ligase_Gene	FBXW7 Gene|AGO|Archipelago Homologue|CDC4|F-box and WD-40 Domain Protein 7 (Archipelago Homolog, Drosophila) Gene|FBW7|FBX30|FBXW7|FLJ11071|SEL-10|SEL10	The FBXW7 gene (F-Box family) on chromosome 4 encodes splice variants of alpha and beta AGO Protein. These isoforms differ only in their N-termini and contain the putative functional F box and seven WD repeats. F-box proteins (Fbws, Fbls, and Fbxs subclasses) constitute one of four SCF subunits of the ubiquitin protein ligase complex, involved in phosphorylation-dependent ubiquitination. The protein encoded by this gene belongs to the Fbws subclass, binds directly to cyclin E, and probably targets cyclin E for ubiquitin-mediated degradation. Expressed in nonproliferating cells of most or all tissues, CDC4 has a 110 kD and a 69 kD isoform.  AGO mutant cells have elevated levels of cyclin E protein without increased cyclin E mRNA levels.  This gene may represent an important mutational target in ovarian cancer. (from OMIM, Proteome, and NCI)
C20787	GA_Gene	Hydrolase_Gene	GLS2 Gene|GA|GLS2|Glutaminase 2 (Liver, Mitochondrial) Gene|LGA|Liver Mitochondrial Glutaminase Gene|hLGA	Human GA Gene on chromosome 12 encodes a deduced 602 amino acid Glutaminase with a putative N-terminal mitochondrial import presequence.  A 2.4 kb transcript exists in liver, brain, and pancreas, but not in kidney, heart, skeletal muscle, lung, or placenta.  The GA protein shares 94% and 72% sequence identity with rat liver and kidney glutaminases, respectively.  Human glutaminase is most similar to rat liver-type glutaminase, but is not liver specific.  Glutaminase activity and mRNA expression levels depend on cell proliferation state with highest levels at the beginning of the exponential growth phase. (NCI)
C20788	GAGED3_Gene	Gene_with_Unknown_or_Unclassified_Function	XAGE2 Gene|GAGED3|GAGED3 Gene|X Antigen Family, Member 2 Gene|XAGE2	Strongly expressed in testis and placenta, human GAGED3 Gene (GAGE Family) at Xp11.21-p11.22 encodes 111-aa 12-kD GAGED3 Protein, of unknown function and similar to other GAGE/PAGE proteins, as well as to Pyridoxal-Dependent Decarboxylase Conserved Domain (C. elegans) and Larval Locomotory Behavior Glutamate Decarboxylase (Drosophila). GAGE-like genes contain a secondary open reading frame, coding for putative homologues of XAGE-1 protein. GAGED3 also belongs to the CT Family. (NCI)
C20789	CLCA2_Gene	Ion_Channel_Protein_Gene	CLCA2 Gene|CLCA2|CaCC|Chloride Channel, Calcium Activated, Family Member 2 Gene	The A2 gene (CLCA family) at 1p31-p22 produces a 3.6 kb transcript in trachea and mammary gland, in addition to lung. The encoded Calcium-Activated Chloride Channel-2 is 51% identical to human CLCA1 and displays an outward rectifying conductance of anions. CLCA2 may be expressed as a 120 kD primary translation product cleaved into an 86 kD N-terminal polypeptide and a 34 kD C-terminal polypeptide, both associated with the cell surface. Expressed predominantly in trachea and lung, calcium-activated chloride channel-2 may play a role in the pathogenesis of cystic fibrosis. It may also serve as adhesion molecule for lung metastatic cancer cells, mediating vascular arrest and colonization. CLCA2 has also been implicated as a tumor suppressor gene for breast cancer. (from SWISS-PROT, OMIM, Proteome, and NCI)
C20790	HYOU1_Gene	Cytoplasmic_Protein_Gene	HYOU1 Gene|HYOU1|Hypoxia Up-Regulated 1 Gene|ORP150	Highly expressed in secretory tissues (liver and pancreas) and induced by hypoxic stress, human HYOU1 Gene (HSP70 Family) at 11q23.1-q23.3 encodes 999-aa (precursor) 150 kD Hypoxia Up-Regulated 1 Protein, an endoplasmic reticulum cytoprotectant in oxygen deprivation that may act as a chaperone with GRPs and participate in protein folding and secretion. ORP150 contains a C-terminal KNDEL sequence and N-terminal similarity to HSP70 ATPase domain. ORP150 suppression is associated with accelerated apoptosis. ORP150 expression in neurons suppresses caspase-3-like activity and enhances BDNF under hypoxia signaling. Elimination of the signal peptide through an alternative translation site may generate a cytosolic housekeeping protein. (NCI)
C20791	ADAM_Family_Gene	Protease_Gene	ADAM Family Gene	ADAMs (A Disintegrin and Metalloproteinase Domain) are membrane-anchored proteases that regulate cell behavior by proteolytically modifying the cell surface and extracellular matrix. Currently, the ADAM family has 29 members, although the function of most ADAM gene products is unknown. The ADAM gene products with known functions act in a highly diverse set of biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-alpha release and the inflammatory response. (from J Cell Biol 2002;159:893-902 and NCI)
C20792	ADAM11_Gene	ADAM_Family_Gene	ADAM11 Gene|A Disintegrin and Metalloproteinase Domain 11 Gene|ADAM11|MDC	Human ADAM11 Gene (ADAM Family, Peptidase M12b Family) at 17q21.3 consists of twenty-eight exons spanning at least 23 kb that encode Disintegrin and Metalloprotease (ADAM) Domain 11, a type I membrane protein. Alternative splicing generates two transcripts that encode MDC-769 and MDC-524. Implicated in cell-cell/-matrix interactions of muscle development, neurogenesis, and fertilization, membrane-anchored ADAM zinc metalloproteases contain disintegrin domains related to snake venom disintegrins. A putative integrin ligand, ADAM11 is a metalloprotease-like noncatalytic protein predominantly expressed in brain that contains an EGF-like domain and a conserved disintegrin domain AVN(E/D)CD motif. The precursor may be cleaved by a furin endopeptidase. Rearrangements that disrupt the coding region occur in breast and ovarian cancers. (from LocusLink 4185, Swiss-Prot O75078, OMIM 155120, and NCI)
C20793	IL24_Gene	Interleukin_Gene	IL24 Gene|IL24|Interleukin 24 Gene|MDA7|ST16	Tightly linked to IL10, IL19, and IL20 within a 195 kb region (IL10 family cytokine cluster), human IL24 Gene (IL10 family) at 1q32 encompasses seven exons that encode secreted Interleukin 24 Protein consisting of 206 amino acids with a predicted size of 23.8 kD.  IL24 appears to represent a differentiation-, growth-, and apoptosis-associated gene.  Expression of IL24 is growth inhibitory toward diverse human tumor cells and may contribute to terminal cell differentiation.  IL24 protein selectively induces p53 independent apoptosis in breast carcinoma cells and inhibits tumor growth in nude mice.  IL24 is up regulated and antiproliferative, or a negative regulator of progression, in human melanoma cells induced to terminally differentiate.  The IL24 gene may have utility for gene-based therapy of diverse human cancers. (from SWISS-PROT, OMIM, Proteome, and NCI)
C20794	MLN51_Gene	Gene_with_Unknown_or_Unclassified_Function	CASC3 Gene|CASC3|Cancer Susceptibility Candidate 3 Gene|MLN51	Ubiquitously expressed and spanning more than 49 kb, human MLN51 Gene at 17q11-q21.3 encodes a cytoplasmic MLN51 Protein containing 703 residues that shares no significant homology to any known protein.  MLN51 is well conserved between vertebrate and invertebrate species suggesting an important function.  The N-terminal half contains putative nuclear localization signals and a coiled-coil domain that seems to promote MLN51 oligomerization.  The C-terminal half contains a SH2 and four SH3 binding motifs.  The carboxy terminus may regulate localization of the protein to the nucleus.  The unusual combination of protein-protein interaction domains in MLN51 suggests a possible nucleo-cytoplasmic function.  Malignant epithelial cells in breast carcinomas show over expression of MLN51. (from Oncogene 2002; 21:4422, SWISS-PROT, LocusLink, and NCI)
C20795	NY-BR-20_Gene	Gene_with_Unknown_or_Unclassified_Function	CALML4 Gene|CALML4|Calmodulin-Like 4|Calmodulin-Like 4 Gene|MGC4809|NY-BR-20	calmodulin-like 4 gene.Spanning more than 13 kb, human NY-BR-20 Gene at 15q23 encodes a protein of unknown function.  (from SWISS-PROT, LocusLink, and NCI)
C20796	NY-BR-84_Gene	Gene_with_Unknown_or_Unclassified_Function	SDBCAG84 Gene|2310015B14RIK|C20ORF47|CGI-54|NY-BR-84|PRO0989|SDBCAG84|Serologically Defined Breast Cancer Antigen 84 Gene	Spanning more than 15 kb, the widely expressed human NY-BR-84 Gene at 20pter-q12 encodes a protein of unknown function similar to acyl-CoA thioesterase (C. elegans) and serologically defined breast cancer antigen 84 (Mouse). (from SWISS-PROT, LocusLink, and NCI)
C20797	C6orf49_Gene	Gene_with_Unknown_or_Unclassified_Function	C6orf49 Gene|C6orf49|Chromosome 6 Open Reading Frame 49 Gene|OBTP	Spanning more than 9 kb, human OBTP Gene at 6p21.31 encodes Over-Expressed Breast Tumor Protein, which contains two LIM domains and may mediate protein-protein interactions.  (from SWISS-PROT, Proteome, and NCI)
C20798	PHEMX_Gene	Gene_with_Unknown_or_Unclassified_Function|Transmembrane_Protein_Gene	PHEMX Gene|MGC22455|PHEMX|PHMX|Pan-Hematopoietic Expression Gene|TSSC6|Tetraspanin Gene|Tumor-Suppressing STF cDNA 6	This gene is one of several located on tumor-suppressing subtransferable fragments from the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is located among several imprinted genes; however, this gene, as well as the tumor-suppressing subchromosomal transferable fragment 4 (TSSC4), escapes imprinting. This gene may play a role in malignancies and disease that involve this region as well as hematopoietic cell function. This gene is described as a member of the tetraspanin superfamily. (from LocusLink)
C20799	BCAA_Gene	Ligand_Binding_Protein_Gene	ARID4B Gene|ARID4B|AT Rich Interactive Domain 4B (RBP1- Like) Gene|BCAA|BRCAA1|KIAA0117|RBBP1L1	Human RBBP1L1 Gene at 1q42.1-q43 encodes RBP1-Like Protein, similar to RBP1, containing a Tudor domain and an ARID DNA binding domain.  Alternatively spliced transcript variants encoding different protein isoforms are thought to exist, but all have not been fully determined.  Transcript variants utilizing alternative polyA sites have also been observed.  Transcript variant 1 encodes a full-length RBP1-like protein isoform 1.  Lacking exon 18, variant 2 encodes a shorter isoform 2 that lacks an internal protein fragment.  (from SWISS-PROT, LocusLink, and NCI)
C20800	LOC118430_Gene	Gene_with_Unknown_or_Unclassified_Function	LOC118430 Gene|LOC118430|SBEM|Small Breast Epithelial Mucin Gene	Expressed only in mammary and salivary glands, human Small Breast Epithelial Mucin Gene at 12q spans more than 3.7 kb and is predicted to encode a putative low molecular weight secreted sialoglycoprotein, potentially useful for the diagnosis of metastatic breast cancer.  (from Cancer Res 2002; 62:2736, SWISS-PROT, LocusLink, and NCI)
C20801	TACC2_Gene	Gene_with_Unknown_or_Unclassified_Function	TACC2 Gene|AZU-1|Anti Zuai-1|TACC2|Transforming, Acidic, Coiled-Coil-Containing Protein 2 Gene	Cell culture studies demonstrate that TACC2 interacts with GAS41 and the SWI/SNF chromatin remodeling complex. This suggests that defects in TACC2 expression may affect gene regulation, thus contributing to the pathogenesis of some tumors. (from Genomics 2003;81:192-201)
C20802	TRAF4_Gene	Signaling_Pathway_Gene	TRAF4 Gene|CART1|MLN62|TNF Receptor-Associated Factor 4 Gene|TRAF4	The 5.5 kb human TRAF4 Gene consists of seven exons and encodes a predicted 470 amino acid TNF Receptor-Associated Factor 4 Protein that has an unusual N-terminal RING-type zinc finger motif, a more central cysteine-rich domain containing a CART motif, and a C terminal TRAF domain.  TRAF4 is a member of a family of proteins that interact with TNF receptors and appears to be involved in TNF-related cytokine signal transduction. (from SWISS-PROT, OMIM, Proteome, and NCI)
C20803	TSSC4_Gene	Gene_with_Unknown_or_Unclassified_Function	TSSC4 Gene|TSSC4|Tumor Suppressing STF cDNA 4|Tumor Suppressing Subtransferable Candidate 4|Tumor Suppressing Subtransferable Candidate 4 Gene	Expressed as a 1.6 kb transcript in fetal brain, lung, liver, and kidney, the human TSSC4 gene at 11p15.5 encodes a protein that shows no close similarity to previously reported proteins. TSSC4 is located in an important tumor-suppressor gene region spanning approximately 1 Mb and containing seven imprinted genes: IGF2, H19, ASCL2, KCNQ1, CDKN1C, TSSC5, and TSSC3. Except for IGF2, each gene is expressed from the maternal allele. A 2.5 Mb STF with proximal D11S12 and distal D11S1318 markers contains the imprinted gene cluster and suppresses growth of the rhabdomyosarcoma cell line RD. In the center of the imprinted gene cluster, TSSC4 and PHEMX genes are not imprinted in any fetal or extraembryonic tissues examined. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, as well as lung, ovarian, and breast cancer. (from SWISS-PROT, OMIM, and NCI)
C20804	MSMB_Gene	Ligand_Binding_Protein_Gene	MSMB Gene|IGBF|MSMB|MSP|MSPB|Microseminoprotein, Beta- Gene|PN44|PRPS|PSP|PSP-94|PSP57|PSP94	Human MSMB Gene (Ig Binding Factor Family, Beta-Microseminoprotein Family) at 10q11.2 encodes secreted Beta-Microseminoprotein isoforms PSP94 and PSP57 in alternative transcripts. Alternate polyadenylation sites are also found. Strongly expressed in prostate, liver, kidney, breast, and penis, Beta-Microseminoprotein is also expressed in pancreas, esophagus, stomach, duodenum, colon, trachea, lung, salivary glands, and fallopian tube. PSP94 is also expressed in lung and breast, while PSP57 is found in kidney and bladder. Specific receptors are found on spermatozoa and in the prostate. The protein has inhibin-like activity; it may have an autocrine paracrine role in uterine, breast, and other female reproductive tissues. It inhibits pituitary secretion of FSH. MSMB protein expression is decreased in prostate cancer. (from Swiss-Prot P08118, OMIM 157145, and NCI)
C20805	BLM_Gene	Helicase_Gene	BLM Gene|BLM|BS|Bloom Syndrome Gene|RECQ2|RECQL2|RECQL3	The Bloom syndrome gene product is related to the RecQ subset of DExH box-containing DNA helicases and has both DNA-stimulated ATPase and ATP-dependent DNA helicase activities. Mutations causing Bloom syndrome delete or alter helicase motifs and may disable the 3'-5' helicase activity. The normal protein may act to suppress inappropriate recombination. (LocusLink)
C20806	WFDC1_Gene	Gene_with_Unknown_or_Unclassified_Function	WFDC1 Gene|PS20|WAP Four-Disulfide Core Domain 1 Gene|WFDC1	Containing seven exons, human WFDC1 Gene (WAP family) at 16q24.3 encodes a deduced 220 amino acid secretory Prostate Stromal Protein ps20, a growth inhibitor that contains a WAP four-disulfide core domain characteristic of protease inhibitors.  The WAP signature motif contains eight cysteines forming four disulfide bonds at the core of proteins that functions as a protease inhibitor in many family members.  Human ps20 shares approximately 86% and 88% identity with rat and mouse proteins, secreted growth inhibitors.  The candidate tumor suppressor WFDC1 gene is located less than 2 Mb from the telomere in an area of frequent loss of heterozygosity in prostate, breast, and hepatocellular cancers and in Wilms' tumor. (from SWISS-PROT, OMIM, Proteome, and NCI)
C20807	WNT4_Gene	WNT_Family_Gene	WNT4 Gene|P56705|WNT4|Wingless-Type MMTV Integration Site Family, Member 4 Gene	The WNT4 gene (WNT family) at 1p35 encodes WNT4 Protein, a cysteine-rich glycoprotein ligand for seven transmembrane frizzled receptors and a putative secreted paracrine signaling molecule that influences the sex-determination cascade. Wnt4 transcripts are detected in brain, lung, and kidney mesenchyme. Ureteric bud growth from the Wolffian duct into presumptive kidney mesenchyme initiates kidney development. In response to a ureter signal, mesenchymal cells condense, aggregate, and differentiate into an epithelial tubule, which morphogenetically transforms into the excretory nephron. Wnt4 may be an autoinducer of nephric mesenchyme-to-epithelial transition. WNT4 up regulates DAX1 (antagonizes SRY) controlling female development and preventing testes formation. WNT4 may be associated with abnormal proliferation in breast tissue. (from SWISS-PROT, OMIM, and NCI)
C20808	ABCG2_Gene	Transport_Protein_Gene	ABCG2 Gene|ABC15|ABCG2|ABCP|ATP-Binding Cassette, Sub-Family G (WHITE), Member 2 Gene|BCRP|BCRP1|BMDP|EST157481|MRX|MXR|MXR1	Highly expressed in the placenta, the human ABCG2 gene (ABC family) at 4q22 makes two transcripts differing at the 5-prime end that encode the same protein. The promoter has a CCAAT box but lacks a TATA box. The ATP Binding Cassette Transporter G2 Protein functions as a membrane-associated homodimeric or homooligomeric xenobiotic transporter in multi-drug resistance. ATP-binding cassette membrane transporters comprise one of the largest protein classes known and are involved in trafficking biologic molecules across extra- and intracellular membranes. ABC genes are divided into seven subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White (ABCG). Multidrug-resistant human breast cancer and colon carcinoma cells express an ABCG2 mRNA that confers resistance to mitoxantrone, doxorubicin, and daunorubicin, reduces intracellular anthracycline and daunorubicin accumulation, and causes an ATP-dependent enhancement of rhodamine-123 efflux. (NCI)
C20809	RAD54L_Gene	DNA_Repair_Gene	RAD54L Gene|HR54 Gene|HRAD54 Gene|RAD54 Homolog Gene|RAD54-Like Protein Gene|RAD54-like (S. cerevisiae) Gene|RAD54L	The RAD54L gene encodes RAD54-Like Protein (RAD54L), a protein that belongs to the DEAD-like helicase superfamily. RAD54L plays a role in homologous recombination related repair of DNA double-strand breaks. The binding of RAD54L to double-strand DNA induces a DNA topological change, which facilitates homologous DNA paring and stimulates DNA recombination. (From LocusLink)
C20810	Platelet_Basic_Protein	Alpha_Chemokine	Platelet Basic Protein|PBP|PPBP	A product of the PPBP gene, pro-platelet basic protein is processed into platelet basic protein (PBP) and connective-tissue-activating peptide III (CTAP-III).  Upon platelet activation these proteins undergo further processing into beta thromboglobulin (Beta-TG) and neutrophil-activating peptide 2 (NAP2), respectively.  Many of the function ascribed to CTAP-III may actually be the result of processing to NAP-2.
C20811	Platelet_Factor-4	Alpha_Chemokine	Platelet Factor 4|Chemokine (C-X-C motif) Ligand 4|PF4|Small Inducible Cytokine B4|Small Inducible Cytokine Subfamily B, Member 4	Platelet factor-4 is a 70-amino acid CXC chemokine. It is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. (from OMIM)
C20812	Coagulation	Coagulation_Process	Coagulation|Blood Coagulation|Clotting	The process of clot formation. (from On-line Medical Dictionary)
C20813	RAD51_Family_Gene	DNA_Repair_Gene	RAD51 Family Gene	The RAD51 family of related genes, identified in both yeast and humans, encode strand-transfer proteins thought to be involved in recombinational repair of DNA damage and in meiotic recombination. Several members of the mammalian RAD51 gene family have been identified, for example, RAD51A, RAD51B, XRCC3, DMC1, and RAD51C. (From OMIM 602774)
C20814	RAD51C_Gene	RAD51_Family_Gene	RAD51C Gene|RAD51 Homolog C (S. cerevisiae) Gene|RAD51 Homolog C Gene|RAD51C|RAD51L2	Human RAD51C Gene (RECA Family, RAD51 Subfamily) at 17q encodes DNA Repair Protein RAD51 Homolog 3, a probable 376-amino acid nuclear protein likely involved in meiotic recombination and repair of damaged DNA. Three alternative variants have been observed with highest expression in testis, heart muscle, spleen, and prostate. RAD51 family members are strand-transfer proteins thought to be involved in recombinational repair of damaged DNA and in meiotic recombination. RAD51C protein interacts strongly with RAD51B and moderately with XRCC3 DNA repair proteins, but not with itself. The RAD51C/XRCC3 complex binds single-stranded, but not duplex, DNA. (from Swiss-Prot O43502, OMIM 602774, and NCI)
C20815	NOVA1_Gene	NOVA_Family_Gene	NOVA1 Gene|NOVA1|Neuro-Oncological Ventral Antigen 1 Gene|Ri Antigen Gene	Human NOVA1 Gene (NOVA Family) at 14q encodes NOVA-1, a neuron-specific nuclear RNA-binding protein containing three KH domains. Alternative transcript variants differ by a seventy-two base pair exon H, as well as by a nine base pair motif. NOVA-1 may regulate RNA splicing or metabolism in specific developing neurons. Murine Nova1 is expressed in ventral spinal cord, brain stem nuclei, deep cerebellar nuclei, and hypothalamus. It binds RNA in a sequence-specific manner to regulate neuron-specific splicing of inhibitory receptor pre-mRNAs in postnatal motor neurons. Nova1 also specifically binds to the GLRA2 intronic sequence (UCAUY)3. Antibodies against NOVA-1 occur in paraneoplastic opsoclonus-ataxia (POA). (from LocusLink 4857, Swiss-Prot P51513, OMIM 602157, and NCI)
C20816	TXN_Gene	Oxidoreductase_Gene	TXN Gene|TRX|TXN|Thioredoxin Gene	Thioredoxin is an oxidoreductase enzyme of 12,000 daltons, containing a dithiol-disulfide active site. Thioredoxin catalyzes intracellular disulfide reductions but also has cytokine activity with interleukins after leaderless secretion. (from OMIM and COPE)
C20817	Paraneoplastic_Disease_Antigen_Gene	Retired_Concepts	Paraneoplastic Disease Antigen Gene
C20818	NOVA_Family_Gene	Ligand_Binding_Protein_Gene	NOVA Family Gene	Expressed in brain (neurons or astrocytes), NOVA Family Genes encode NOVA Family nuclear proteins (NOVA1, NOVA2), autoantigens in POMA recognized by IgG ANNA-2 that contain 3 KH domains and may regulate RNA splicing in neurons and astrocytes. NOVA proteins form structural complexes with other proteins. Found as one or multiple copies of a conserved 70-aa motif in diverse nucleic acid binding, and other, proteins, the KH domain binds RNA; each motif appears necessary for binding. (NCI)
C20819	Nucleoporin_Gene	Transport_Protein_Gene	Nucleoporin Gene	These genes encode proteins that function in the nuclear transport of protein and RNA. Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. (from LocusLink 4928, OMIM 601021)
C20820	NUP98_Gene	Nucleoporin_Gene	NUP98 Gene|NUP96 Gene|NUP98|Nucleoporin, 98-kD Gene	Up regulated by interferon, human NUP98 Gene (GLFG Nucleoporin Family) in an imprinted domain at 11p15 encodes Nucleoporin 98 kD in several alternative variants. Proteolytic cleavage of a 186 kD precursor yields NUP98 and NUP96, both located at the multiprotein nuclear pore complex (NPC) nucleoplasmic side. NUP96 and NUP98 targeting to the NPC is dependent on cleavage. NUP98 may function as a docking protein for import. The C-terminal RNA-binding domain of NUP98 contains NPC target sequences, a novel protein fold, and an autocatalytic protease; docking/transport function is located in the N-terminal GLFG/FXFG repeats. Vesicular Stomatitis Virus M Protein targets NUP98. Translocations in several myeloid leukemias fuse NUP98 to other genes; t(7;11)(p15;p15) generates N-terminal NUP98 fused in-frame to HOXA9. (from LocusLink 4928, Swiss-Prot P52948, OMIM 601021, and NCI)
C20821	Nurse	Medical_Occupation	Nurse	A health professional trained to care for people who are ill or disabled.
C20822	Licensed_Practical_Nurse	Nurse	Licensed Practical Nurse|LPN|LVN|Licensed Vocational Nurse	Licensed Practical Nurse - a professional healthcare provider who has graduated from an accredited licensed practical nursing program, has passed the state exam for licensure, and been licensed to practice by a state authority.
C20823	Strategic_Supplement_Program	Research_Support	Strategic Supplement Program	Research funding program designed to take advantage of high priority research opportunities that can be completed in short time frames. (2003 Bypass Budget)
C20824	Registered_Nurse	Nurse	Registered Nurse|R.N.|RN	Registered Nurse (R.N.) - a nurse who has graduated from an accredited registered nursing program, has passed the state exam for licensure, and been registered and licensed to practice by a state authority.  R.N.s receive educational preparation through hospital-based diploma programs, community/junior college associate's degree programs, baccalaureate programs, or combinations thereof.
C20825	Advanced_Practice_Nurse	Registered_Nurse	Advanced Practice Nurse|APN	A registered nurse, usually prepared at the master's degree level or higher, who functions within a specialty area within nursing practice.  Advanced practice nurses make independent and collaborative health care decisions. Advanced practice nurses are expert clinicians engaged in active practice. The advanced practice nurse demonstrates leadership as a consultant, educator, administrator and researcher. An important leadership function of all advanced practice nurses is participation in legislative and professional activities to promote professional advancement and health related social policies. (from AANP)
C20826	Molecular_Diagnosis	Diagnosis	Molecular Diagnosis	The use of molecular tools and techniques, especially gene and protein expression profiles, to diagnose disease.
C20827	Optical_Biopsy	Imaging_Technique	Optical Biopsy	Use of optical coherence tomography to capture ulta-high resolution images of tissue surfaces which can be used to identify cancerous legions.
C20828	Optical_Coherence_Tomography	Imaging_Technique	Optical Coherence Tomography	Optical Coherence Tomography (OCT) combines the principles of ultrasound with the imaging performance of a microscope.  OCT uses infrared light waves that reflect off the internal microstructure within the biological tissues. The frequencies and bandwidths of infrared light are orders of magnitude higher than medical ultrasound signals, resulting in greatly increased image resolution, 8-25 times greater than any existing modality. In addition to providing high-level resolutions for the evaluation of microanatomic structures OCT is also able to provide information regarding tissue composition. (from http://www.lightlabimaging.com/oct.html)
C20829	SLC22A1L_Gene	Transport_Protein_Gene	SLC22A18 Gene|BWR1A|BWSCR1A|HET|IMPT1|ITM|ORCTL2|SLC22A18|SLC22A1L|SLC22A1L Gene|Solute Carrier Family 22 (Organic Cation Transporter), Member 18 Gene|TSSC5|p45-BWR1A	Preferentially expressed from the maternal chromosome predominantly in fetal and adult liver and kidney as 2 alternative transcripts, 23-kb 11-exon human SLC22A1L Gene (Polyspecific Transporter/MDR Family) in an imprinted gene domain at 11p15.5 encodes 424-aa Tumor Suppressing Subtransferable Candidate 5 Protein (Organic Cation Transporter-Like 2 Protein), a polyspecific organic-cation transporter containing 10 transmembrane segments and involved in excretion of endogenous and exogenous compounds. Divergent SLC22A1L and ORCTL2S genes overlap; ORCTL2S exon 1 shares 31 bp with SLC22A1L exon 2. SLC22A1L translation may begin at the second methionine, which would result in a 408-amino acid protein. (NCI)
C20830	Certified_Nurse_Midwife	Advanced_Practice_Nurse	Certified Nurse Midwife|CNM|Nurse Midwife	Certified nurse-midwive (CNM) - licensed health care practitioner educated in the two disciplines of nursing and midwifery. CNMs provide primary health care to women of childbearing age including: prenatal care, labor and delivery care, care after birth, gynecological exams, newborn care, assistance with family planning decisions, preconception care, menopausal management and counseling in health maintenance and disease prevention. (ACNM)
C20831	Certified_Registered_Nurse_Anesthetist	Advanced_Practice_Nurse	Certified Registered Nurse Anesthetist|CRNA|Nurse Anesthesiologist|Nurse Anesthetist	Certified Registered Nurse Anesthetist (CRNA) - a registered nurse who provides anesthetics to patients in collaboration with surgeons, anesthesiologists, dentists, podiatrists, and other qualified healthcare professionals.  CRNAs practice with a high level of autonomy in most surgical practice settings. (AANA)
C20832	Clinical_Nurse_Specialist	Advanced_Practice_Nurse	Clinical Nurse Specialist|CNS|Clin Spec	Clinical Nurse Specialist (CNS) - a licensed registered nurse who has graduate preparation (a master's or a doctorate) in nursing as a CNS.  The CNS is a clinical expert in theory-based and/or research-based nursing practice within a specialty area. (NACNS)
C20833	Cardiovascular_Nurse	Clinical_Nurse_Specialist	Cardiovascular Nurse|Cardiac Care Nurse|Cardiac Nurse|Cardiac/Vascular Nurse	Cardiac/Vascular nurses provide comprehensive nursing care to individuals diagnosed with cardiac/vascular disease as well as those identified at risk for cardiac/vascular events. These services are provided in a variety of settings including acute and ambulatory care facilities, community-based facilities, and work-site and school-based programs. Cardiac/vascular nursing practice promotes achievement and maintenance of optimal cardiac/vascular wellness.  The cardiac/vascular nurse is responsible for the development, coordination, and evaluation of a plan of care that uses a multi-disciplinary/case management approach. While concentrating on cardiac/vascular health, the practice considers all influences on health status and the related social and behavioral problems. The theoretical basis for this nursing practice incorporates physiological and psychosocial concepts of health as they affect cardiac/vascular wellness. (ANCC)
C20834	Community_Health_Nurse_Specialist	Clinical_Nurse_Specialist	Community Health Nurse Specialist|CHN|Clinical Specialist in Community Health Nursing|Community Health Nurse|Public Health Nurse	A registered nurse prepared at the master's degree level or higher who specializes in exploring and meeting the needs of select populations in community contexts. (UMD, SON)
C20835	Diabetes_Management_Nurse_Specialist	Clinical_Nurse_Specialist	Diabetes Management Nurse Specialist|Clinical Specialist in Diabetes Management|Diabetic Educator	The Advanced Diabetes Management Practitioner has an advanced degree and is able to (1) perform complete and/or focused assessments, (2) recognize and prioritize complex data in order to identify needs of patients with diabetes across the life span, and (3) provide therapeutic problem-solving, counseling, and regimen adjustments.  The scope of advanced diabetes practice includes management skills such as medication adjustment, medical nutrition therapy, exercise planning, counseling for behavior management and psychosocial issues. Attaining optimal metabolic control may include treatment and monitoring of acute and chronic complications.  The depth of knowledge and competence in advanced clinical practice and diabetes skills affords an increased complexity of decision making, which expands the traditional discipline specific practice. Research, publications, mentoring, and continuing professional development are expected skill sets. (ANCC)
C20836	Enterostomal_Therapy_Nurse_Specialist	Clinical_Nurse_Specialist	Enterostomal Therapy Nurse Specialist|Clinical Specialist in Wound, Ostomy, and Continence|ET Nurse|WOC Nurse|Wound, Ostomy, and Continence Nurse	Wound, Ostomy and Continence (WOC) Nurses manage conditions such as stomas, draining wounds, fistulas, vascular ulcers, pressure ulcers, neuropathic wounds, urinary incontinence, fecal incontinence, and functional disorders of the bowel and bladder. (WOCN)
C20837	Gerontological_Nurse_Specialist	Clinical_Nurse_Specialist	Gerontological Nurse Specialist|Clinical Specialist in Gerontological Nursing	Clinical specialists in gerontological nursing are experts in providing, directing, and influencing the care of older adults and their families and significant others in a variety of settings. Clinical specialists demonstrate an in-depth understanding of the dynamics of aging, as well as of the interventions necessary for health promotion and management of health status alterations. Clinical specialists provide comprehensive gerontological nursing services independently or collaboratively with multidisciplinary teams. Through theory and research; clinical specialists advance the health care of older adults and the specialty of gerontological nursing. Clinical specialists are engaged in practice, case management, education, consultation, research, and administration. (ANCC)
C20838	Home_Health_Nurse_Specialist	Clinical_Nurse_Specialist	Home Health Nurse Specialist|Clinical Specialist in Home Health Nursing	Home health nursing refers to the practice of nursing applied to a client with a health deficit in the client's place of residence or appropriate community site. The graduate-prepared clinical specialist in home health nursing can and may be asked to perform all the functions of a generalist. In addition, the clinical specialist possesses substantial clinical experience with clients who are individuals, families, and groups. The clinical specialist has expertise in the process of case management, consultation, collaboration, and education of clients, staff, and other health professionals.  In addition, the clinical specialist has proficiency in planning, implementing, and evaluating programs, resources, services, and research for health care delivery to complex clients. (ANCC)
C20839	PHB_Gene	Regulatory_Gene	PHB Gene|PHB|Prohibitin Gene	Evolutionarily conserved, ubiquitously expressed human PHB Gene (Prohibitin Family) at 17q21 encodes Prohibitin, a 30 kD cytoplasmic antiproliferative protein that inhibits DNA synthesis, regulates proliferation, and may be a tumor suppressor. Prohibitin is expressed as two transcripts with varying lengths of 3-prime UTR.  The longer transcript is present at higher levels in proliferating cells; the longer 3-prime UTR may act as a trans regulator. The human prohibitin family consists of one functional gene and four processed pseudogenes: PHBP1, PHBP2, PHBP3, and PHBP4. Mutations in PHB have been linked to sporadic breast cancer. (from Swiss-Prot P35232, OMIM 176705, and NCI)
C20840	Medical-Surgical_Nurse_Specialist	Clinical_Nurse_Specialist	Medical-Surgical Nurse Specialist|Clinical Specialist in Medical-Surgical Nursing	Graduate-prepared clinical specialists in Medical-Surgical Nursing provide care for individuals who have a known or predicted physiological alteration. Clinical specialists demonstrate an in-depth understanding of complex medical-surgical problems, as well as interventions to manage and improve patient care. Guided by theory and research, their practice considers all influences on health status and the related social and behavioral problems arising because of the patient's physiological condition. Clinical specialists are engaged in education, case management, expert clinical practice, consultation, research, and administration. Clinical specialists practice in settings where primary, acute, or long-term nursing care is delivered. (ANCC)
C20841	Nurse_Psychotherapist	Advanced_Practice_Nurse	Nurse Psychotherapist|Mental Health Nurse|Psychiatric Nurse
C20842	Oncology_Nurse_Specialist	Clinical_Nurse_Specialist	Oncology Nurse Specialist|Cancer Nursing Specialist|Chemotherapy Nursing Specialist|Clinical Specialist in Oncology Nursing|ONS	A clinical nurse specialist that provides a high level of supportive and therapeutic care to cancer patients and their families.  The ONS is an excellent resource for current trends in cancer care and therapies.
C20843	Pediatric_Nurse_Specialist	Clinical_Nurse_Specialist	Pediatric Nurse Specialist|Clinical Specialist in Pediatric Nursing	The clinical specialist in pediatric nursing is a graduate-prepared clinician and child and family advocate. Within the scope of pediatric nursing practice the child and family are considered the client. Clinical specialists demonstrate an in-depth understanding of complex pediatric health care by engaging in education, case management, expert clinical practice, consultation, research and administration.  Change and systems theory are utilized to develop interventions to manage and improve patient care. Clinical specialists in pediatric nursing practice across the trajectory of care in settings which include primary, acute, community, or rehabilitation. (ANCC)
C20844	Nurse_Educator	Advanced_Practice_Nurse	Nurse Educator|Clinical Faculty|Clinical Nurse Educator|Nursing Faculty|Nursing Staff Developer|Nursing Staff Development Specialist	Nurse educators are registered nurses prepared at the graduate or doctoral level who prepare students for nursing practice at a variety of levels, including entry level, continuing education, advanced practice, and specialty practice.  Nurse educators work in various settings, including colleges/universities, community colleges, hospitals, nursing homes, private practice, etc.
C20845	Ribosome_Subunit_Gene	Translation_Process_Gene	Ribosome Subunit Gene	Ribosome Subunit Genes encode Ribosomal Proteins, present in either the small or the large ribosomal subunit and involved in protein synthesis. In eukaryotes there are 50 proteins in the large subunit and 33 in the small subunit. (NCI)
C20846	RPL13_Gene	Ribosome_Subunit_Gene	RPL13 Gene|BBC1 Gene|Breast Basic Conserved Gene 1|D16S444E Gene|RPL13|Ribosomal Protein L13 Gene	The highly conserved human RPL13 Gene (L13E Ribosomal Protein Family) encodes Ribosomal Protein L13, a cytoplasmic ribosomal 60S subunit protein. One major transcript and variants (alternative splicing or polyadenylation) encode the same protein. Typical of ribosomal protein genes, there are multiple processed genomic pseudogenes. The protein is highly basic with no signal or transmembrane sequence, but it has two potential nuclear localization signals. Ribosomes consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately eighty structurally distinct proteins. (from Swiss-Prot P26373, OMIM 113703, and NCI)
C20847	Ribonucleotide_Reductase_Subunit_Gene	Oxidoreductase_Gene	Ribonucleotide Reductase Subunit Gene	Ribonucleotide Reductase Subunit Genes (RRM1 and RRM2) encode the M1 Chain and M2 Chain subunits of Ribonucleoside-Diphosphate Reductase, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. A substrate site and catalytic site regulate enzyme activity. Allosteric control by deoxynucleoside triphosphates and by ATP bound to M1 prevents DNA replication and cell proliferation. An M1 catalytic site only forms in the presence of M2. M2 synthesis is cell-cycle dependent. p53 regulates ribonucleotide reductase by interaction with p53R2 as well as the M2 subunit. (NCI)
C20848	RRM1_Gene	Ribonucleotide_Reductase_Subunit_Gene	RRM1 Gene|R1 Gene|RR1|RRM1|Ribonucleoside-Diphosphate Reductase M1 Chain Gene|Ribonucleotide Reductase M1 Polypeptide Gene|Ribonucleotide Reductase, Large Subunit Gene|Ribonucleotide Reductase, M1 Subunit Gene|Ribonucleotide Reductase, R1 Subunit Gene	The human RRM1 Gene at 11p15.5 encodes Ribonucleoside-Diphosphate Reductase M1 Chain, which is 1 of 2 ribonucleoside-diphosphate reductase subunits, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Complex allosteric control, mediated by deoxynucleoside triphosphates, and by ATP bound to the M1 subunit prevents DNA replication and cell proliferation. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. RRM1 functions as a metastasis suppressor gene through induction of PTEN expression and PTEN-regulated pathways. (from Swiss-Prot, OMIM, LocusLink and NCI)
C20849	S100_Family_Gene	Ligand_Binding_Protein_Gene	S100 Family Gene	S100 Family Gene members, many clustered on chromosome 1q21, encode S100 Calcium Binding Proteins localized in the cytoplasm and/or nucleus of many cells that often regulate cellular processes such as cell cycle progression and differentiation.
C20850	S100A2_Gene	S100_Family_Gene	S100A2 Gene|S100 Calcium-Binding Protein A2 Gene|S100A2|S100L Gene	Clustered with at least twelve S100 genes, human S100A2 Gene at 1q21 encodes S-100L Protein, a S100 Family EF-hand cell-specific Ca2+-binding protein. S100A1, closest to the telomere, and S100A1 are located within 450 kb; S100A9 is nearest the centromere. Preferentially expressed in mammary epithelia and keratinocytes, DNA methylation may suppress S100A2; expression is induced by growth factors in G1 and by cell-cycle regulation in S phase. Cytoplasmic and nuclear S100 proteins regulate cell cycle progression and differentiation. Containing two EF-hand domains, S-100L Protein interacts with target proteins to link extracellular stimuli to cellular responses and may modulate excess calcium accumulation. S100A2 levels correlate inversely with tumor progression. Chromosomal rearrangements and altered expression of S100A2 have been implicated in breast cancer. (from LocusLink 6273, Swiss-Prot P29034, OMIM 176993, and NCI)
C20851	Centers_of_Excellence_in_Cancer_Communications_Research	Centers_of_Research_Excellence	Centers of Excellence in Cancer Communications Research
C20852	Nurse_Practitioner	Advanced_Practice_Nurse	Nurse Practitioner	A registered nurse (RN) with advanced training in diagnosing and treating illness.  NPs are master's degree prepared health experts that focus on helping patients achieve total health and prevent disease.  NPs focus on disease prevention, wellness, and patient education.  NPs prescribe medications, treat illness, and perform physical examinations.  NPs can function independently of physician intervention, but require a practice agreement with a physician.
C20853	Case_Management_Nurse	Advanced_Practice_Nurse	Case Management Nurse|Care Manager|Case Manager	Case management includes nursing activities of coordination, advocacy, and referral. These activities involve facilitating service delivery on behalf of the client, communicating with health and human service providers, promoting assertive client communication, and guiding the client toward use of appropriate community resources.
C20854	Non-Clinical_Specialty_Nurse	Advanced_Practice_Nurse	Non-Clinical Specialty Nurse	Professions that require the skills and experiences of nurses, but do not require actual patient contact on a regular basis.
C20855	Informatics_Nurse_Specialist	Non-Clinical_Specialty_Nurse	Informatics Nurse Specialist|INS|Informatics Nurse|Nurse Informatician|Nurse Informaticist	An Informatics Nurse encompasses the full range of activities that focus on the methods and technologies of information handling in nursing. Informatics nursing practice includes the development, support, and evaluation of applications, tools, processes, and structures that assist the practice of nurses with the management of data in direct care of patients/clients. The work of an informatics nurse can involve any and all aspects of information systems, including theory formulation, design, development, marketing, selection, testing, implementation, training, maintenance, evaluation, and enhancement.  Informatics nurses are engaged in clinical practice, education, consultation, research, administration, and pure informatics. (ANCC).
C20856	Neurodegenerative_Disease_Gene	Retired_Concepts	Neurodegenerative Disease Gene
C20857	Synuclein_Family_Gene	Retired_Concepts	Synuclein Family Gene
C20858	SNCG_Gene	Cytoplasmic_Protein_Gene	SNCG Gene|BCSG1 Gene|Breast Cancer-Specific Gene 1|PRSN|Persyn Gene|SNCG|Synuclein, Gamma (Breast Cancer-Specific Protein 1) Gene|Synuclein, Gamma Gene	Highly conserved human SNCG Gene (Synuclein Family) at 10q23.2-q23.3 contains five exons that encode 127-amino acid cytoplasmic Gamma-Synuclein, similar to amyloid protein nonamyloid beta fragment, alpha-synuclein, and beta-synuclein.  Gamma-Synuclein may modulate axonal architecture and neurofilament integrity. It may promote Ca2+-dependent protease susceptibility of neurofilament-H and modulate the keratin network. GRK5 phosphorylation occurs on residues distinct from other kinase targets. Gamma-Synuclein may be involved in the pathogenesis of neurodegenerative diseases. Protein levels increase in aging cerebral cortex and SNCG is expressed at a high level in advanced infiltrating breast cancer. (from Swiss-Prot O76070, OMIM 602998, and NCI)
C20859	Nurse_Administrator	Non-Clinical_Specialty_Nurse	Nurse Administrator|DON|Director of Nursing|Nurse Executive|Nursing Administration|Vice President for Nursing	Nurse executives are registered nurses who are instrumental in the design, facilitation, and management of patient care in their respective organizations. They hold titles such as chief nursing officer, nursing director, chief operating officer of health care facilities and systems, nurse manager, consultant in nursing administration and management, dean, and director of faculty in graduate and undergraduate nursing programs. (from AONE)
C20860	Nurse_Specialist_in_Health_and_Public_Policy	Non-Clinical_Specialty_Nurse	Nurse Specialist in Health and Public Policy|Nursing Health Policy Specialist	Nursing Health Policy Specialists are Registered Nurses academically prepared at the graduate level who analyze, evaluate, and propose public and institutional policy that affects health care availability, accessibility, and delivery within a given population, region, or facility.
C20861	Unlicensed_Assistive_Personnel	Miscellaneous_Occupations	Unlicensed Assistive Personnel	Personnel trained to assist with the direct care of patients in all health settings and in the home.  Unlicensed Assistive Personnel work under the direct supervision of RNs to extend the abilities of the nurse to provide for patients' activities of daily living.
C20862	STIM1_Gene	Transmembrane_Protein_Gene	STIM1 Gene|GOK Gene|STIM1|Stromal Interaction Molecule 1 Gene	Located in an imprinted domain, ubiquitously expressed human STIM1 Gene at 11p15.5 is oriented head-to-tail with RRM1; its 3-prime end is 1.6 kb from the RRM1 5-prime end. Similar to the murine gene, STIM1 contains twelve exons over more than 250 kb between RRM1 and NUP98. STIM1 encodes Stromal Interaction Molecule 1 Protein, a potential glycosylated cell surface type 1 transmembrane protein that influences the survival or proliferation of B cell precursors and may act as an adhesion molecule in hematopoiesis by mediating attachment to stromal cells. Phosphorylated mainly on serine residues, the 746-amino acid protein contains a predicted signal peptide, a transmembrane helix, and one SAM domain. STIM1 oligomerizes with STIM2 and cell binding may require Mn(II). Defects in STIM1 may cause rhabdomyosarcoma and rhabdoid tumors. (from LocusLink 6786, Swiss-Prot Q13586, OMIM 605921, and NCI)
C20863	Stimulation_of_Cell_Proliferation	Cell_Proliferation_Regulation	Stimulation of Cell Proliferation|Mitogenesis|Positive Control of Cell Proliferation	Stimulation of Cell Proliferation involves intercellular, cellular, and subcellular mechanisms that induce, promote, sustain, or ensure cell division.
C20864	TACC1_Gene	Gene_with_Unknown_or_Unclassified_Function	TACC1 Gene|KIAA1103|TACC1|Transforming, Acidic, Coiled-Coil-Containing Protein 1 Gene	Located close to FGFR1, human TACC1 Gene (TACC Family) at 8p11 is highly expressed during embryogenesis as a major 8.0 kb transcript in all tissues tested. The 805-amino acid TACC1 Protein is rich in serine, proline, and acidic residues; has a 20-amino acid tryptophan-rich N-terminus; contains two nuclear localization signals, but no DNA- or RNA-binding domains; and has a 200-residue C-terminus with extensive alpha-helical segments expected to adopt a coiled-coil structure. Although the nuclear protein is concentrated at centrosomes and interacts with microtubules and tubulin, its function is not yet determined. TACC1 is a potential breast cancer candidate gene. (from LocusLink 6867, Swiss-Prot O75410, OMIM 605301, and NCI)
C20865	Information_and_Media	NCI_Administrative_Concepts	Information and Media
C20866	Ambulatory_Care_Nursing	Nursing	Ambulatory Care Nursing|Clinic Nursing|Office Nursing	Nursing care provided in an ambulatory setting, such as a clinic or physician's office.
C20867	Cardiac_Vascular_Nursing	Nursing	Cardiac/Vascular Nursing|Cardiac Care Nursing|Cardiac Nursing|Cardiovascular Nursing	Cardiac/Vascular nursing is the provision of comprehensive nursing care to individuals diagnosed with cardiac/vascular disease as well as those identified at risk for cardiac/vascular events. These services are provided in a variety of settings including acute and ambulatory care facilities, community-based facilities, and work-site and school-based programs. Cardiac/vascular nursing practice promotes achievement and maintenance of optimal cardiac/vascular wellness.  The cardiac/vascular nurse is responsible for the development, coordination, and evaluation of a plan of care that uses a multi-disciplinary/case management approach. While concentrating on cardiac/vascular health, the practice considers all influences on health status and the related social and behavioral problems. The theoretical basis for this nursing practice incorporates physiological and psychosocial concepts of health as they affect cardiac/vascular wellness. (ANCC)
C20868	Clinical_Nursing	Nursing	Clinical Nursing|Nursing Sciences, Clinical	Clinical nursing applies the skills and processes of nursing to patients in an acute care environment.
C20869	Hospital_Nursing	Clinical_Nursing	Hospital Nursing	The provision of professional nursing care in an inpatient setting.
C20870	Long-Term_Care_Nursing	Clinical_Nursing	Long-Term Care Nursing|Nursing Home Nursing	Professional nursing care provided in a long-term care/nursing facility to residents unable to provide for themselves a safe and adequate level of care.
C20871	Trefoil_Family_Gene	Retired_Concepts	Trefoil Family Gene
C20872	TFF1_Gene	Regulatory_Gene	TFF1 Gene|BCEI|D21S21|HPS2|TFF1|Trefoil Factor 1 (Breast Cancer, Estrogen-Inducible Sequence Expressed In) Gene|pNR-2|pS2	Altered expression, deletion, and/or mutations of the TFF1 gene are frequently observed in human gastric carcinomas.  Thus, it has been classified as a gastric tumor suppressor gene.  TFF1 represses cell progression towards the S phase of the cell cycle, and therefore proliferation.  However, TFF1 has a complex role in that it is not only a potent inhibitor of proliferation, but also an efficient inhibitor of apoptosis.  Similar dual and paradoxical functions have already been reported for tumor suppressor genes involved in cell differentiation. (from J Cell Biol 2002;157:761-70)
C20873	GPR39_Gene	G_Protein-Coupled_Receptor_Gene	GPR39 Gene|G Protein-Coupled Receptor 39 Gene|GPR39	GPR39 is a single-copy gene, expressed in brain and other peripheral tissues. It encodes a protein with high homology to the growth hormone secretagogue receptor (GHSR), a G protein-coupled receptor found in the pituitary gland and brain that is involved in the control of growth hormone release. The ligand-binding and functional properties of GPR39 remain to be determined. (from OMIM and Genomics 1997;46:426-34)
C20874	Medical-Surgical_Nursing	Clinical_Nursing	Medical-Surgical Nursing|Med/Surg Nursing	Medical-Surgical Nursing includes the provision of care to individuals who have a known or predicted physiological alteration. Working within an interdisciplinary team and guided by theory and research, medical-surgical nursing practice considers all influences on health status and the related social and behavioral problems arising because of the patient's physiological condition.  Medical-surgical nursing is practiced in primary, acute, or long-term nursing care facilities. (from ANCC)
C20875	Orthopedic_Nursing	Clinical_Nursing	Orthopedic Nursing|Orthopaedic Nursing	Nursing care with a special emphasis on the care of individuals with orthopaedic-related injuries, diseases, and diagnoses.
C20876	Subacute_Nursing	Clinical_Nursing	Subacute Nursing|Sub-Acute Care|Subacute Care	Medical and skilled nursing services provided to patients who are not in an acute phase of an illness but who require a level of care higher than that provided in a long-term care setting. (JCAHO, Lexikon, 1994)
C20877	Clinical_Research_Nursing	Clinical_Nursing	Clinical Research Nursing	Professional nursing care provided in a research environment.  Including management of clinical trials, direct patient care, and research assistance.
C20878	Flight_Nursing	Critical_Care_Nursing	Flight Nursing	The provision of emergency or supportive nursing care to patients transported by helicopters or fixed-wing aircraft.
C20879	OR_Nursing	Critical_Care_Nursing	OR Nursing|Perioperative Nursing|Surgical Nursing	Nursing care of the surgical patient before, during, and after surgery.
C20880	Perianesthesia_Nursing	Critical_Care_Nursing	Perianesthesia Nursing	Nursing care of the patient under anesthesia and in the immediate post-anesthesia period.
C20881	Emergency_Room_Nursing	Critical_Care_Nursing	Emergency Room Nursing|ED Nursing|ER Nursing|Emergency Nursing	The specialty or practice of nursing in the care of patients admitted to the emergency department.
C20882	Trauma_Nursing	Critical_Care_Nursing	Trauma Nursing	Critical Care Nursing specialty devoted to the care of the traumatically injured patient.
C20883	Home_Health_Nursing	Nursing	Home Health Nursing|Visiting Nursing	Professional nursing care provided within the home of the individual under care.
C20884	Infusion_Nursing	Nursing	Infusion Nursing|Hyperalimentation Nursing|IV Nursing|Intravenous Nursing	Intravenous nursing practice involves all aspects of infusion therapy, including phlebotomy, intravenous peripheral and central access line placement (PICC), chemotherapy, hyperalimentation, etc.
C20885	Neonatal_Nursing	Nursing	Neonatal Nursing	Nursing care of the newborn infant.
C20886	MSLN_Gene	Gene_with_Unknown_or_Unclassified_Function	MSLN Gene|CAK1|MPF|MSLN|Mesothelin Gene	This gene encodes mesothelin.  Although its function is unknown, it may play a role in cellular adhesion and is present on mesothelium, mesotheliomas, and ovarian cancers. Three transcript variants have been described for this gene and their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. The protein isoform named MPF is a cytokine with megakaryocyte potentiating activity. The soluble member encoded by the third splice variant is detected in ovarian carcinoma; the full length sequence of the third variant has not been described. (LocusLink)
C20887	Mesothelin	Protein_with_Unknown_or_Unclassified_Function	Mesothelin|MSLN|Megakaryocyte Potentiating Factor|Soluble Mpf/Mesothelin-Related Protein	An antibody that reacts with ovarian cancers and mesotheliomas was used to isolate a cell surface antigen named mesothelin. Although the function of mesothelin is unknown, it may play a role in cellular adhesion and is present on mesothelium, mesotheliomas, and ovarian cancers. Three transcript variants have been described for this gene and their protein products were initially named megakaryocyte potentiating factor (MPF), mesothelin, and the soluble member(s) of the mesothelin/MPF family. The protein isoform named MPF is a cytokine with megakaryocyte potentiating activity. The soluble member encoded by the third splice variant is detected in ovarian carcinoma; the full length sequence of the third variant has not been described. (LocusLink)
C20888	Obstetrical_Nursing	Gynecological_Obstetrical_Nursing	Obstetrical Nursing|Obstetric Nursing	Nursing care given to the pregnant patient before, during, or after childbirth.
C20889	Palliative_Care_Nursing	Nursing	Palliative Care Nursing|End-of-life Nursing|Hospice Nursing	Nursing specialized in providing palliative care.  It's aim is to provide relief from pain and other symptoms.  This care includes support, counseling, and education for both the patient and their family.
C20890	Pediatric_Nursing	Nursing	Pediatric Nursing|Pediatric/Adolescence Nursing	The nursing care of children from birth to adolescence. It includes the clinical and psychological aspects of nursing care.
C20891	WFDC2_Gene	Gene_with_Unknown_or_Unclassified_Function	WFDC2 Gene|HE4|WAP Four-Disulfide Core Domain 2 Gene|WAP5|WFDC2|dJ461P17.6	This gene generates 5 alternatively spliced transcript variants, which encode 5 different protein isoforms. These isoforms contain one or two WAP-type four-disulfide core (WFDC) domains, and are thus members of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded isoforms are small secretory proteins, which may be involved in sperm maturation. (LocusLink)
C20892	Camp_Nursing	Public_Health_Nursing	Camp Nursing	Health and nursing care given to campers at a summer or children's camp by a registered nurse.
C20893	Epididymal_Secretory_Protein-E4	Protein_with_Unknown_or_Unclassified_Function	Epididymal Secretory Protein E4|EP4|Epididymis-Specific Whey-Acidic Type Four-Disulfide Core Protein|Major Epididymis-Specific Protein E4|Putative Protease Inhibitor WAP5|WAP Domain Containing Protein HE4-V4|WAP Four-Disulfide Core Domain Protein 2|WFDC2	Expressed in several tissues, including male reproductive system, respiratory tract, and nasopharynx as 5 alternatively spliced transcripts, human WFDC2 Gene (WFDC Family) encodes 5 secreted isoforms of Epididymal Secretory Protein E4 that contain one or two WFDC domains. The WFDC domain contains eight cysteines forming four disulfide bonds at the protein core and often functions in protease inhibition. WFDC2 may be involved in sperm maturation. (NCI)
C20894	Developmental_Disabilities_Nursing	Public_Health_Nursing	Developmental Disabilities Nursing	Nursing care provided for children and adults with developmental disabilities in the homes, schools, and communities to maximize their ability to interact and function in the community at large.
C20895	Epidemiology_Nursing	Public_Health_Nursing	Epidemiology Nursing	The application of nursing principles to the study of the patterns of disease or other events across populations.
C20896	Transplant_Nursing	Nursing	Transplant Nursing	Nursing care provided to the transplant recipient and donor.
C20897	TSSC1_Gene	Gene_with_Unknown_or_Unclassified_Function	TSSC1 Gene|TSSC1|Tumor Suppressing Subtransferable Candidate 1 Gene	This gene was identified as one of several residing in tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. (from LocusLink)
C20898	PHLDA2_Gene	Gene_with_Unknown_or_Unclassified_Function	PHLDA2 Gene|BRW1C|BWR1C|HLDA2|IPL|PHLDA2|Pleckstrin Homology-Like Domain, Family A, Member 2 Gene|TSSC3|TSSC3 Gene	Human TSSC3 Gene at 11p15.5 is located in a 1 Mb imprinted tumor-suppressor gene domain that includes H19, IGF2, CDKN1C, and KVLQT1. A 170 kb subregion between D11S601 and D11S679 contains NAP2, CDKN1C, KVLQT1, BWR1A, BWR1B, and TSSC3. TSSC3 is located between centromeric NAP2 and telomeric CDKN1C. Like other imprinted genes, TSSC3 is small with small introns; TSSC3 contains a single 223 base pair intron and encodes TSSC3 Protein. TSSC3 is maternally expressed in placenta, liver, fetal and adult liver, lung, and kidney, adult pancreas, and fetal tissues. Similar to TDAG51, essential for FAS expression and apoptosis susceptibility, TSSC3 may also be involved in susceptibility to apoptosis. Mouse Tssc3 encodes a small cytoplasmic protein with a pleckstrin-homology (PH) domain. (from Swiss-Prot O00496, OMIM 602131, and NCI)
C20899	ELF3_Gene	Transcription_Coactivator_Gene	ELF3 Gene|E74-Like Factor 3 (ETS Domain Transcription Factor, Epithelial-Specific) Gene|ELF3|EPR-1|ERT|ESE-1|ESX|JEN	Expressed exclusively in epithelial cells, the 6-kb 9-exon human ELF3 Gene (ETS Family) at 1q32.2 encodes E74-Like Factor 3, an ETS domain and A/T hook domain transcriptional activator that regulates expression of epithelial-specific genes. (NCI)
C20900	E74-Like_Factor-3	ETS_Family_Protein|Transcription_Coactivator	E74-Like Factor 3|E74-Like Factor 3 ETS Domain Transcription Factor|E74-Like Factor 3 ETS Domain Transcription Factor, Epithelial-Specific|E74-Like Factor 3 ETS Domain Transcription Factor, Serine Box, Epithelial-Specific|ELF3|ELF3 Protein|ESE1|ESX Protein|ETS Domain Transcription Factor, Epithelial-Specific|ETS Domain Transcription Factor, Serine Box|ETS Domain Transcription Factor, Serine Box Epithelial-Specific|Epithelium-Specific ETS Factor 1	ESX, a novel member of the ETS transcription factor family, is a tumor marker exclusively expressed in epithelial cells.  ESX contains two putative DNA-binding domains: an ETS domain and an A/T hook domain. (NCI)
C20901	Restraining_Placental_Growth	Biochemical_Process	Restraining Placental Growth	Restraining Placental Growth involves mechanisms that impede continued expansion of the placenta.
C20902	SLPI_Gene	Proteinase_Inhibitor_Gene	SLPI Gene|ALK1|ALP|BLPI|HUSI|HUSI-I|SLPI|SLPIa|Secretory Leukocyte Protease Inhibitor (Antileukoproteinase) Gene	This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes; the protein is also thought to have broad-spectrum anti-biotic activity. (From LocusLink)
C20903	WNT3_Gene	WNT_Family_Gene	WNT3 Gene|INT4 Gene|WNT3|Wingless-Type MMTV Integration Site Family, Member 3 Gene	A wingless (Drosophila) homolog, human WNT3 Gene (WNT Family) at 17q21 is clustered with WNT15 and encodes WNT-3 Protein, with 98% amino acid identity to mouse Wnt3 and 84% to human WNT3A. Comparison to mouse protein sequence shows four changes in 333 amino acids. Highly-conserved structurally related WNT genes encode 350-400 amino acid, cysteine-rich, putative paracrine signaling glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. Wnt3 is required in mouse primary axis formation and ectodermal anterior-posterior neural patterning. WNT3 may play a role in some cancers through activation of the WNT-beta-catenin-TCF signaling pathway. (from LocusLink 7473, Swiss-Prot P56703, OMIM 165330, and NCI)
C20904	SLC5A5_Gene	Transport_Protein_Gene	SLC5A5 Gene|NIS Gene|SLC5A5|Sodium-Iodide Symporter Gene|Solute Carrier Family 2 (Facilitated Glucose/Fructose Transporter), Member 5 Gene	The sodium-iodide symporter (NIS), a member of the sodium/solute symporter family, actively transports iodide across the basolateral plasma membrane of the thyroid follicular cells. (LocusLink)
C20905	WNT10B_Gene	WNT_Family_Gene	WNT10B Gene|WNT10B|WNT12|Wingless-Type MMTV Integration Site Family, Member 10B Gene	Clustered head-to-head with WNT1 in a 7 kb interval, human WNT10B Gene (WNT Family) at 12q13 encodes a 389-amino acid WNT-10B Protein in five exons. WNT1-WNT10B may have derived from duplication. Highly-conserved structurally related WNT genes encode 350-400 amino acid, cysteine-rich, putative paracrine signaling glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning and cell growth or differentiation in some adult mammalian tissues. WNT10B expression is highest in heart and skeletal muscle; low levels are found in. WNT10B nucleotide sequence is 96% identical to murine Wnt10b. WNT10B appears to maintain undifferentiated preadipocytes by inhibition of CEBPA and PPAR-gamma. Axin blockage of WNT signaling induces adipocyte differentiation. (from LocusLink 7480, Swiss-Prot O00744, OMIM 601906, and NCI)
C20906	Adipogenesis	Biosynthesis	Adipogenesis|Lipogenesis	The production of fat, either fatty degeneration or fatty infiltration; also applied to the normal deposition of fat or to the conversion of carbohydrate or protein to fat. (On-Line Medical Dictionary)
C20907	CCL2_Gene	CC_Cytokine_Gene	CCL2 Gene|CCL2|GDCF-2|GDCF-2 HC11|HC11|MCAF|MCP-1|MCP1|MGC9434|SCYA2|SMC-CF	Human CCL2 Gene encodes Small Inducible Cytokine A2, a chemotactic chemokine for monocytes and basophils, but not neutrophils or eosinophils, produced by monocytic and lymphocytic leukocytes and by fibroblasts during tissue injury that binds to chemokine receptors CCR2 and CCR4. (NCI)
C20908	ZNF147_Gene	Ligand_Binding_Protein_Gene	TRIM25 Gene|EFP Gene|Estrogen-Responsive Finger Protein Gene|TRIM25|Tripartite Motif-Containing 25 Gene|ZNF147|ZNF147 Gene|Zinc Finger Protein 147 Gene	Within 300 kb of MPO, human ZNF147 Gene (TRIM Family, RING Finger Family) at 17q23.1 encodes a ubiquitous cytoplasmic estrogen-responsive Zinc Finger Protein 147. Gene expression is up regulated via a 3-prime UTR ERE. Putative DNA-binding and dimerization-transactivation domains suggest ZNF147 to be a transcription factor, similar to other TRIM family members. The TRIM motif includes three zinc-binding domains, a SPRY domain, a RING, a B-Box Type 1 and Type 2, and a coiled-coil region. Zinc Finger Protein 147 is a RING-finger-dependent ubiquitin ligase (E3) that targets proteolysis of 14-3-3-sigma, a negative cell cycle regulator that causes G2 arrest. Lack of EFP function results in 14-3-3-sigma accumulation; 14-3-3-sigma is a target for proteolysis by EFP, leading to cell proliferation. (from LocusLink 7706, Swiss-Prot Q14258, OMIM 600453, and NCI)
C20909	Small_Inducible_Cytokine-A2	Beta_Chemokine	Small Inducible Cytokine A2|CCL2|Monocyte Chemoattractant Protein-1|Monocyte Chemotactic Protein-1|Monocyte Chemotactic and Activating Protein|Monocyte Secretory Protein JE	A chemokine that is a chemoattractant for human monocytes and may also cause cellular activation of specific functions related to host defense. It is produced by leukocytes of both monocyte and lymphocyte lineage and by fibroblasts during tissue injury. (MeSH Definition)
C20910	WNT1_Inducible_Signaling_Pathway_Protein-1	Signaling_Protein	WNT1 Inducible Signaling Pathway Protein 1|WISP1|WISP1 Protein|WNT-1-Induced Secreted Protein	Associated with cell survival and expressed in fibroblasts (high), heart, kidney, lung, pancreas, placenta, ovary, small intestine, and spleen by human WISP1 Gene (WISP/CCN/CTGF Family), 367-aa 40-kDa (precursor) and 280-aa isoforms of secreted WNT1 Inducible Signaling Pathway Protein 1 contain 4 conserved Cys-rich domains: a IGFBP domain, a VWFC domain, a TSP type-1 domain, and a CTCK domain. WISP1 up-regulates anti-apoptotic BCL-X(L) protein and attenuates p53-mediated apoptosis induced by DNA damage through activation of AKT kinase. WISP1 binds to, and may prevent the anti-proliferation activity of, decorin and biglycan, small leucine-rich connective tissue extracellular matrix proteoglycans. WISP1 may act as a downstream regulator in the WNT/Frizzled signaling pathway. (NCI)
C20911	WISP1_Gene	Growth_Factor_Gene	WISP1 Gene|CCN4|WISP1	Associated with cell survival and expressed in fibroblasts (high), heart, kidney, lung, pancreas, placenta, ovary, small intestine, and spleen, human WISP1 Gene (WISP/CCN/CTGF Family) encodes alternative, 367-aa 40-kDa (precursor) and 280-aa, isoforms of secreted WNT1 Inducible Signaling Pathway Protein 1, containing 4 conserved Cys-rich domains: a IGFBP domain, a VWFC domain, a TSP type-1 domain, and a CTCK domain. WISP1 up-regulates anti-apoptotic BCL-X(L) protein and attenuates p53-mediated apoptosis induced by DNA damage through activation of AKT kinase. WISP1 binds to, and may prevent the anti-proliferation activity of, decorin and biglycan, small leucine-rich connective tissue extracellular matrix proteoglycans. WISP1 may act as a downstream regulator in the WNT/Frizzled signaling pathway. (NCI)
C20912	Cytokine_Receptor_Gene	Receptor_Gene	Cytokine Receptor Gene	Cytokine Receptor Genes encode cell surface Cytokine Receptors that bind paracrine or autocrine cytokine growth factors that stimulate humoral and cellular immune responses, as well as activation of phagocytic cells. Cytokines are secreted by inflammatory leukocytes (lymphokines), by monocytes or macrophages (monokines), and by various other cells. Interleukin lymphokines, targeted to cells of hematopoietic origin, are not secreted by leukocytes but affect the cellular responses of leukocytes. (NCI)
C20913	TGFB3_Gene	Transforming_Growth_Factor-Beta_Family_Gene	TGFB3 Gene|TGFB3|Transforming Growth Factor, Beta 3 Gene	The TGFB3 gene at 14q24 encodes Transforming Growth Factor Beta 3, a member of the TGF-beta cytokine family. This secreted protein is expressed as a disulfide-linked homodimer in a wide variety of mesenchymal tissues during human embryogenesis. Transforming Growth Factor Beta 3 is involved in cell differentiation. (from OMIM, Swiss-Prot and NCI)
C20914	Uterine_Swelling	Tissue_Growth	Uterine Swelling	With a high concentration of estrogen receptors, the uterus is one of the most sensitive tissues to the hormone and demonstrates two basic responses to estrogen: it swells by influx of water into the lumen of the uterus, and it increases in weight by the growth of the endometrial layer. (http://www.fda.gov/cdrh/ost/rpt97/OST1997AR13.HTM)
C20915	BRCD2_Gene	Gene_with_Unknown_or_Unclassified_Function	BRCD2 Gene|BCDS2|BRCD2|Breast Cancer Suppressor-2|Breast Cancer, Ductal (2) Gene	Inactivation of Breast Cancer Suppressor-2, encoded by the BRCD2 gene, may represent a fundamental step in the pathogenesis of ductal carcinoma of the breast. (OMIM, LocusLink, and NCI)
C20916	SHFM1_Gene	Ligand_Binding_Protein_Gene	SHFM1 Gene|DSS1|Deleted In Split-Hand/Split-Foot 1 Region|Deleted in Split-Hand/Split-Foot 1 Region Gene|ECD|SEM1|SHFD1|SHFDG1|SHFM1|SHSF1|Split Hand/Foot Malformation (Ectrodactyly) Type 1 Gene	Human DSS1 Gene (DSS1/SEM1 Family) at 7q21.3-q22.1 encodes DSS1 Protein, a highly conserved acidic protein expressed predominantly in limb bud, craniofacial primordia, and skin. DSS1 may be involved in completion of the cell cycle or in differentiation. DSS1 is a homolog of SEM1 (S. cerevisiae), a highly conserved likely regulator of the exocyst complex function and pseudohyphal differentiation. SEM1 protein is mainly cytosolic. DSS1 Protein interacts with a 90 kD C-terminal domain of BRCA2 that binds single-stranded DNA and contains three oligonucleotide-binding folds and a helix-turn-helix motif. DSS1 may be involved in Split Hand/Split Foot Malformation, a limb developmental disorder. (from Swiss-Prot Q13437, OMIM 601285, and NCI)
C20917	Cell_Cycle_Gene	Gene	Cell Cycle Gene	Cell Cycle Genes encode Cell Cycle Proteins, which control the cell division cycle. This family of proteins, classified on the basis of related function, includes a wide variety of classes, including cyclin-dependent kinases, mitogen-activated kinases, cyclins, and phosphoprotein phosphatases, as well as their putative substrates, such as chromatin-associated proteins, cytoskeletal proteins, and transcription factors. (NCI)
C20918	Cell_Cycle_Completion	Cell_Division_Process	Cell Cycle Completion|Completion of Cell Cycle	Processes that mark, promote, or produce the conclusion of cell division and promote cell entry into interphase (G0/G1). (NCI)
C20919	BRCATA_Gene	Gene_with_Unknown_or_Unclassified_Function	BRCATA Gene|BRCATA|Breast Cancer, 11;22 Translocation Associated Gene	The most frequently occurring constitutional reciprocal translocation in man is t(11;22)(q23;q11). The number of breast cancer cases is significantly higher than expected among the translocation carriers. The information should be useful in connection with counseling and screening. The BRCATA gene may be involved in the pathogenesis of breast cancer and is located at chromosome 11q23. (from OMIM 600048)
C20920	Whey_Protein	Supplementation	Whey Protein	The glutathione (GSH) antioxidant system is foremost among the cellular protective mechanisms. Depletion of this small tripeptide molecule is a common consequence of increased formation of reactive oxygen species during increased cellular activities and oxygen radical generation is frequently a critical step in carcinogenesis. Cysteine is the crucial limiting amino acid for intracellular GSH synthesis. Whey protein concentrate represents an effective and safe cysteine donor for GSH replenishment during GSH depletion in immune deficiency states. Animal experiments have shown that the concentrates of whey proteins increase GSH concentration in relevant tissues and may have anti-tumor effect on low volume of tumor via stimulation of immunity through the GSH pathway. (from PMID 11205219)
C20921	Signaling_Pathway_Gene	Gene	Signaling Pathway Gene|Proto-Oncogene, Signaling Factor	Signaling Pathway Genes encode proteins or peptides that participate in intracellular signal transduction processes.
C20922	Axin_2_Protein	Retired_Concepts	Axin 2 Protein
C20923	G_Protein-Coupled_Receptor_Gene	Receptor_Gene	G Protein-Coupled Receptor Gene|GPCR|GPR	These genes encodes G protein-coupled receptors (GPRs or GPCRs). GPRs contain 7 hydrophobic transmembrane domains embedded in hydrophilic intra- and extracellular loops and transduce a variety of hormone, endogenous peptide, and neurotransmitter signals into intracellular effects via G proteins. (from OMIM 604161)
C20924	GPR54_Gene	G_Protein-Coupled_Receptor_Gene	GPR54 Gene|AXOR12|G Protein-Coupled Receptor 54 Gene|GPR54|HOT7T175	The GPR54 gene encodes G Protein-Coupled Receptor 54, which is a G protein-coupled receptor. The endogenous ligand of this protein is the KISS1 protein. The truncated form of KISS1, metastin, inhibits chemotaxis and invasion of GPR54-transfected CHO cells in vitro and attenuates pulmonary metastasis of GPR54-transfected B16-BL6 melanomas in vivo. (from OMIM 604161)
C20925	NOVA2_Gene	NOVA_Family_Gene	NOVA2 Gene|ANOVA Gene|Astrocytic NOVA1-Like Gene|NOVA2|Neurooncologic Ventral Antigen 2 Gene	Expressed in brain, human NOVA2 Gene encodes RNA-binding NOVA2 protein, recognized by the paraneoplastic syndrome antibody anti-Ri. NOVA1 and NOVA2 bind to similar RNA ligands with high affinity and may regulate RNA splicing. The NOVA2 KH3 domain interacts with single-stranded RNA; KH3 bound to stem loop RNA resembles a vise, with UCAC held between an invariant Gly-X-X-Gly motif and a variable loop. Tetranucleotide recognition is supported by an aliphatic alpha-helix/beta-sheet RNA-binding platform that mimics UG by making Watson-Crick-like hydrogen bonds with CA. (NCI)
C20926	FABP2_Gene	FABP_Family_Gene	FABP2 Gene|FABP2|FABPI|Fatty Acid Binding Protein 2, Intestinal Gene|I-FABP	The FABP2 gene encodes Fatty Acid-Binding Protein 2, which belongs to the fatty-acid binding protein (FABP) family thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. The FABP2 gene has a polymorphism in position 54, which changes Ala-54 (71% of the population) to Thr-54 (29%). The Thr-54 allele has a 2-fold greater affinity for long-chain fatty acids than the Ala-54 allele. Thr-54 is associated with increased fat oxidation and insulin resistance. (from LocusLink and Swiss-Prot)
C20927	BCL2L2_Protein	Retired_Concepts	BCL2L2 Protein|Apoptosis Regulator Bcl-W Protein|BCL2 Like 2 Protein
C20928	Baculoviral_IAP_Repeat-Containing_Protein-1	IAP_Family_Protein	Baculoviral IAP Repeat-Containing Protein 1|BIRC1|NAIP|Neuronal Apoptosis Inhibitory Protein	Baculoviral IAP Repeat-Containing Protein 1, encoded by the BIRC1 gene, contains regions of homology to two baculovirus inhibitor of apoptosis proteins, It is able to suppress apoptosis induced by various signals and inhibits apoptosis in neuronal cells.
C20929	XIAP-Associated_Factor-1	Apoptosis_Promoter	XIAP-Associated Factor 1|XAF1|ZAP-1	Widely expressed (highest in heart, ovary; lowest in brain, testis) by human XAF1 Gene (IAP Family), 317-aa 37-kDa XIAP-Associated Factor 1 contains 3 Cys-rich BIR domains (bind to and inhibit caspases), 7 zinc fingers, and a C-terminal RING zinc finger that possesses E3 ubiquitin ligase activity. Associated with nuclear redistribution of XIAP, cytoplasmic XAF1 appears to antagonize nuclear XIAP inhibition of CASP3 activity. (NCI)
C20930	Apoptotic_Protease_Activating_Factor-1	Apoptosis_Promoter	Apoptotic Protease Activating Factor 1|APAF1|APAF1 Protein|Apoptotic Protease Activating Factor	The APF1 protein functions to activate caspase 9 in the cytochrome c/dATP-dependent apoptotic pathway. (from RefSeq Summary)
C20931	Baculoviral_IAP_Repeat-Containing_Protein-2	IAP_Family_Protein	Baculoviral IAP Repeat-Containing Protein 2|Apoptosis Inhibitor 1|BIRC2|Cellular Inhibitor of Apoptosis-1|Human Inhibitor of Apoptosis Protein-2|Mammalian IAP Homolog B	Encoded by BIRC2 Gene (IAP Family), Baculoviral IAP Repeat-Containing Protein 2 inhibits apoptosis by binding to TNF Receptor-associated factors TRAF1 and TRAF2 preventing activation of ICE-like proteases. BIRC2 inhibits apoptosis induced by serum deprivation and menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring finger domain. (NCI)
C20932	Alpha_Adrenergic_Receptor	G_Protein-Coupled_Receptor	Alpha Adrenergic Receptor	Expressed by Alpha Adrenergic Receptor Genes in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Alpha Adrenergic Receptors are one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Alpha-adrenergic receptors respond to blocking agents such as phenoxybenzamine and phentolamine. When coupled to adenylate cyclase through Gi protein, Alpha Adrenergic Receptor stimulation results in decreased intracellular cyclic AMP. (NCI)
C20933	Alpha_Adrenergic_Receptor_Gene	G_Protein-Coupled_Receptor_Gene	Alpha Adrenergic Receptor Gene	Expressed in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Alpha Adrenergic Receptor Genes encode Alpha Adrenergic Receptors, one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Alpha-adrenergic receptors respond to blocking agents such as phenoxybenzamine and phentolamine. When coupled to adenylate cyclase through Gi protein, Alpha Adrenergic Receptor stimulation results in decreased intracellular cyclic AMP. (NCI)
C20934	IAP_Family_Protein	Apoptosis_Inhibitor	IAP Family Protein|IAP Protein|Inhibitor of Apoptosis Protein	Encoded by Mammalian IAP Family Genes, conserved (Inhibitors of Apoptosis) IAP Family Proteins exhibit an N-terminal domain containing 1-3 repeats of a 65-70-aa Cys- and His-rich BIR motif and often a zinc-binding RING finger. Some IAPs inhibit apoptosis by regulating ICE-like protease activation signals and/or inhibit serum deprivation-induced apoptosis. Some IAP proteins may bind to TRAF1 and TRAF2. IAP proteins are frequently over expressed in cancers and associated with resistance to therapy. (NCI)
C20935	Alpha-1B_Adrenergic_Receptor	Alpha_Adrenergic_Receptor	Alpha-1B Adrenergic Receptor|ADRA1B	Encoded by human protooncogene ADRA1B Gene (GPCR1 Family), 519-aa 56.8-kD Alpha-1B Adrenergic Receptor is a Gq/11-associated integral membrane protein that activates mitogenic PI-calcium second messenger responses and controls vascular tone and systolic blood pressure. (NCI)
C20936	ADRA1B_Gene	Alpha_Adrenergic_Receptor_Gene	ADRA1B Gene|ADRA1B|Adrenergic, Alpha-1B-, Receptor Gene|Alpha-1B Adrenergic Receptor Gene	Near ADRB2, ADRA1B, and DRD1A genes and, comprised of 2 exons and a 20-kb intron, 55.8-kb human protooncogene ADRA1B Gene (GPCR1 Family) at 5q23-q32 encodes 519-aa 56.8-kD Alpha-1B Adrenergic Receptor, a Gq/11-associated integral membrane protein that activates mitogenic PI-calcium second messenger responses and controls vascular tone and systolic blood pressure. (NCI)
C20937	AKT3_Gene	Serine-Threonine_Protein_Kinase_Gene	AKT3 Gene|AKT3|DKFZP434N0250|PKBG|PRKBG|RAC-GAMMA|v-akt Murine Thymoma Viral Oncogene Homolog 3 (Protein Kinase B, Gamma) Gene	Highly expressed in brain, lung, kidney and fetal heart, liver, brain, 35.5-kb human AKT3 Gene (AKT/RAC Family) at 1q43-q44 encodes alternative isoforms 1 (479-aa, 55.8-kD) and 2 (465-aa; shorter C-terminus) of cytoplasmic Protein Kinase B Gamma, containing a PH domain that binds PI(3)K alpha and promotes plasma membrane translocation after cell stimulation. Fully active when phosphorylated on threonine and serine residues, AKT3 phosphorylates several proteins to regulate cell signaling responses to insulin, PDGF, and IGF1 involved in cell proliferation, differentiation, apoptosis, glycogen synthesis, and glucose uptake. (NCI)
C20938	IAP_Family_Gene	Apoptosis_Inhibitor_Gene	IAP Family Gene	Mammalian IAP Family Genes encode conserved Inhibitors of Apoptosis Proteins with an N-terminal domain containing 1-3 repeats of a 65-70-aa Cys- and His-rich BIR motif and often a zinc-binding RING finger. Some IAPs inhibit apoptosis by regulating ICE-like protease activation signals and/or inhibit serum deprivation-induced apoptosis. Some IAP proteins may bind to TRAF1 and TRAF2. IAP proteins are frequently over expressed in cancers and associated with resistance to therapy. (NCI)
C20939	Protein_Kinase-B_Gamma	Protein_Kinase_B	Protein Kinase B Gamma|AKT3|V-Akt Murine Thymoma Viral Oncogene Homolog 3	Highly expressed in brain, lung, kidney and fetal heart, liver, brain by human AKT3 Gene (AKT/RAC Family) as alternative isoforms 1 (479-aa, 55.8-kD) and 2 (465-aa; shorter C-terminus), cytoplasmic Protein Kinase B Gamma contains a PH domain that binds PI(3)K alpha and promotes plasma membrane translocation after cell stimulation. Fully active when phosphorylated on threonine and serine residues, AKT3 phosphorylates several proteins to regulate cell signaling responses to insulin, PDGF, and IGF1 involved in cell proliferation, differentiation, apoptosis, glycogen synthesis, and glucose uptake. (NCI)
C20940	ANXA8_Gene	Ligand_Binding_Protein_Gene	ANXA8 Gene|ANX8|ANXA8|Annexin A8 Gene	The 24-kb human ANXA8 Gene (Annexin Family) at 10q11.2 encodes 327-aa 37-kD Annexin A8 protein, containing 4 annexin repeats (possible Ca (2+) and phospholipid binding sites) and a putative indirect inhibitor of the blood coagulation thromboplastin-specific complex. Annexins are Ca (2+)dependent phospholipid binding proteins. ANXA8 exhibits 56% identity to annexin V (vascular anticoagulant-alpha). Annexin VIII is neither an extracellular protein nor associated with the cell surface suggesting that it may not play a role in blood coagulation. It is expressed at low levels in human placenta and shows restricted expression in lung endothelia, skin, liver, and kidney. The gene is selectively overexpressed in acute myelocytic leukemia. (NCI)
C20941	Annexin-A8_Protein	Ligand_Binding_Protein	Annexin A8|ANXA8|Annexin VII|Annexin VIII	Annexin VIII belongs to the family of Ca (2+) dependent phospholipid binding proteins (annexins), and has a high 56% identity to annexin V (vascular anticoagulant-alpha). It was initially isolated as 2.2 kb vascular anticoagulant-beta transcript from human placenta, a Ca (2+) dependent phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. However, the fact that annexin VIII is neither an extracellular protein nor associated with the cell surface suggests that it may not play a role in blood coagulation in vivo and its physiological role remains unknown. (LocusLink)
C20942	Rho_Guanine_Nucleotide_Exchange_Factor-1	Guanine_Nucleotide_Exchange_Factor	Rho Guanine Nucleotide Exchange Factor 1|ARHGEF1|Rho GEF 1	Ubiquitously expressed by human ARHGEF1 Gene as alternative isoforms 1 (912-aa, 102-kD) and 2 (879-aa), cytoplasmic Rho Guanine Nucleotide Exchange Factor 1 contains a (homooligomerizing) coiled coil region, a DH domain, a PH domain, and an RGSL domain (necessary for GAP activity). Responsive to extracellular stimuli acting through GPCRs, ARHGEF1 may complex with G proteins and regulates cell cycle and cell proliferation activity. Phosphorylated by PKCA and translocated to the plasma membrane by stimulation, ARHGEF1 seems to regulate RHOA GTPase signal transduction as a GEF and GNA12 and GNA13 (RGS domain interaction) as a GAP. ARHGEF1 GEF activity is inhibited by binding to activated GNA12. (NCI)
C20943	ARHGEF1_Gene	Signaling_Pathway_Gene	ARHGEF1 Gene|ARHGEF1|GEF1|LBCL2|P115-RHOGEF|Rho Guanine Nucleotide Exchange Factor (GEF) 1 Gene|SUB1.5	Ubiquitously expressed 47-kb human ARHGEF1 Gene at 19q13.13 encodes alternative isoforms 1 (912-aa, 102-kD) and 2 (879-aa) of cytoplasmic Rho Guanine Nucleotide Exchange Factor 1, containing a (homooligomerizing) coiled coil region, a DH domain, a PH domain, and an RGSL domain (necessary for GAP activity). Responsive to extracellular stimuli acting through GPCRs, ARHGEF1 may complex with G proteins and regulates cell cycle and cell proliferation activity. Phosphorylated by PKCA and translocated to the plasma membrane by stimulation, ARHGEF1 seems to regulate RHOA GTPase signal transduction as a GEF and GNA12 and GNA13 (RGS domain interaction) as a GAP. ARHGEF1 GEF activity is inhibited by binding to activated GNA12. (NCI)
C20944	ASCL1_Protein	Retired_Concepts	ASCL1 Protein|Achaete-Scute Complex Homolog-Like 1 Protein
C20945	ACSL1_Gene	Ligase_Gene	ACSL1 Gene|ACS1|ACSL1|Acyl-CoA Synthetase Long-Chain Family Member 1 Gene|FACL1|FACL2|LACS|LACS1|LACS2	Expressed in liver, heart, skeletal muscle, kidney, early erythroid cells, brain, lung, placenta and pancreas, human ACSL1 Gene (Long-Chain Fatty-Acid-CoA Ligase Family) encodes alternative isoforms of 698-aa 78 kDa Acyl-CoA Synthetase Long-Chain Family Member 1, a magnesium-cofactor type III membrane protein likely located in microsomes, outer mitochondrial membranes and peroxisomal membranes. Preferentially using palmitoleate, oleate and linoleate, ACSL1 converts free long-chain fatty acids into fatty acyl-CoA esters for biosynthesis of cellular lipids and degradation via beta-oxidation.
C20946	Baculoviral_IAP_Repeat-Containing_Protein-3	IAP_Family_Protein	Baculoviral IAP Repeat-Containing Protein 3|Apoptosis Inhibitor 2|BIRC3|Cellular Inhibitor of Apoptosis-2|Human Inhibitor of Apoptosis Protein-1|Mammalian IAP Homolog C	Encoded by BIRC3 Gene (IAP Family) Baculoviral IAP Repeat-Containing Protein 3 inhibits apoptosis by binding to TNF Receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. BIRC3 inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. The amino acid sequence predicts three baculovirus IAP repeat domains and a ring-type zinc finger domain while the Zn binding domain is involved in protein-protein interactions in caspase inhibition and spindle assembly. BIRC3 is present in many fetal and adult tissues and mainly expressed in adult skeletal muscle, thymus, testis, ovary, and pancreas, low or absent in brain and peripheral blood leukocytes. (NCI)
C20947	Baculoviral_IAP_Repeat-Containing_Protein-4	IAP_Family_Protein	Baculoviral IAP Repeat-Containing Protein 4|Apoptosis Inhibitor 3|BIRC4|IAP-Like Protein|X-linked Inhibitor of Apoptosis	Encoded BIRC4 Gene (IAP Family), Baculoviral IAP Repeat-Containing Protein 4 inhibits apoptosis through binding to TNF Receptor-associated factors TRAF1 and TRAF2. Similar to BIRC2, BIRC4 inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. BIRC4 also specifically inhibits cell-death proteases, caspase-3 and caspase-7. A novel transcript homologous to BIRC4 is expressed solely in the testis. (NCI)
C20948	AUH_Gene	Ligand_Binding_Protein_Gene	AUH Gene|AU RNA Binding Protein/Enoyl-Coenzyme A Hydratase Gene|AUH	AUH encodes AU-specific RNA-binding enoyl-CoA hydratase that binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. (LocusLink)
C20949	Apollon	Retired_Concepts	Apollon|BIRC6|Baculoviral IAP Repeat-Containing Protein 6|KIAA1289
C20950	AU-RNA_Binding_Protein	RNA_Binding_Protein	AU RNA Binding Protein|3-Methylglutaconyl-CoA Hydratase|AU RNA-Binding Protein|AU RNA-Binding Protein/enoyl-Coenzyme A Hydratase|AU-Specific RNA Binding Protein|AUH|Enoyl-Coenzyme A Hydratase|MGA Type I	AU-specific RNA-binding enoyl-CoA hydratase (AUH) protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. (LocusLink)
C20951	Livin	IAP_Family_Protein	Livin|BIRC7|Baculoviral IAP Repeat-Containing Protein 7|Kidney Inhibitor of Apoptosis|Melanoma Inhibitor of Apoptosis	Encoded by BIRC7 Gene, Livin is a potent anti-apoptotic protein and caspase inhibitor with pleiotropic effects on apoptosis induced by various stimuli. BIRC7 anti-apoptotic activity is achieved by two mechanisms: TAK1-dependent JNK1 activation and caspase inhibition. Induced by a death stimulus, processed and activated SMAC interacts with the BIRC7 BIR (baculovirus IAP repeat) domain to abrogate BIRC7 inhibition of apoptosis. Alpha and beta BIRC7 splice variants have different biological properties and tissue distribution, though both have a significant anti-apoptotic activity. (NCI)
C20952	BAG1_Gene	Signaling_Pathway_Gene	BAG1 Gene|BAG1|BCL2-Associated Athanogene Gene	By splicing and translation initiation, p53-regulated 10.6-kb human BAG1 Gene at 9p12 encodes isoforms 1 (274-aa, 31-kD) and 2 (240-aa) of acidic (pI 5.3) glutamate-rich BAG1 Protein, with a Ubiquitin-like domain and BAG domain. BAG1 may link growth factor receptor and anti-apoptotic signal transduction mechanisms. The C-terminal region interacts with HGFR and PDGFR, but the entire protein is required for anti-apoptotic activity. BAG1 stimulates anti-apoptotic membrane protein BCL2. It also binds to NR3C1 and appears to interact with RAF1 Ser/Thr protein kinase, which promotes BCL2 activity. Bound to the HSP70/HSC70 ATPase domain, BAG1 inhibits chaperone activity by promoting substrate release. BAG1 may suppress GADD34-mediated stress responses, have a role in cell survival, and be involved in developmental processes that require cell death. (NCI)
C20953	BAG1_Protein	Signaling_Protein	BAG1 Protein|BAG1|BCL2-associated Athanogene	Encoded by human BAG1 Gene as isoforms 1 (274-aa, 31-kD) and 2 (240-aa), acidic (pI 5.3) glutamate-rich BAG1 Protein contains a Ubiquitin-like domain and BAG domain. BAG1 may link growth factor receptor and anti-apoptotic signal transduction mechanisms. The C-terminal region interacts with HGFR and PDGFR, but the entire protein is required for anti-apoptotic activity. BAG1 stimulates anti-apoptotic membrane protein BCL2. It also binds to NR3C1 and appears to interact with RAF1 Ser/Thr protein kinase, which promotes BCL2 activity. Bound to the HSP70/HSC70 ATPase domain, BAG1 inhibits chaperone activity by promoting substrate release. BAG1 may suppress GADD34-mediated stress responses, have a role in cell survival, and be involved in developmental processes that require cell death. (NCI)
C20954	BRS3_Gene	G_Protein-Coupled_Receptor_Gene	BRS3 Gene|BRS3|Bombesin-Like Receptor 3 Gene	Expressed in germ cells in the testis, 4-kb 3-exon human BRS3 Gene (GPCR1 Family) encodes 399-aa 44-kDa integral membrane protein Bombesin-like Receptor 3, specifically activated by bombesin-like peptides and associatied with G proteins that activate a phosphatidylinositol-calcium second messenger system. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin receptor subtype-3 (BRS3). BRS3 may be required for sperm cell division, maturation, or function, or for regulation of endocrine processes and metabolism responsible for energy balance and adiposity. (NCI)
C20955	Bombesin-Like_Receptor-3	G_Protein-Coupled_Receptor	Bombesin-like Receptor 3|BRS3	Expressed in germ cells in the testis by human BRS3 Gene (GPCR1 Family), 399-aa 44-kDa integral membrane protein Bombesin-like Receptor 3 is specifically activated by bombesin-like peptides and associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. Bombesin-like peptide receptors include gastrin-releasing peptide receptor, neuromedin B receptor, and bombesin receptor subtype-3 (BRS3). BRS3 may be required for sperm cell division, maturation, or function, or for regulation of endocrine processes and metabolism responsible for energy balance and adiposity. (NCI)
C20956	Cyclin-A2	Cyclin	Cyclin A2|CCNA2|Cyclin A	Expressed at S-phase by human CCNA2 Gene (Cyclin A Subfamily) in all tissues tested (highest in testis), nuclear 432-amino acid 48.5-kD Cyclin A2 accumulates during G2, is abruptly destroyed at mitosis, controls the cell cycle, and promotes both G1/S and G2/M transitions. Inhibition of cyclin A synthesis or activity inhibits DNA synthesis. Highly conserved cyclins (proliferating cell nuclear antigens) regulate CDK kinases. Cyclin A interacts with CDK2 protein kinase and Ser/Thr kinase p34CDC2 (during G2/M) to form a holoenzyme complex; cyclin imparts substrate specificity to the complex. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C20957	CCNA2_Gene	Cyclin_Gene	CCNA2 Gene|CCN1|CCNA|CCNA2|CGA2|Cyclin A2 Gene	Repressed during G1 and activated at S-phase, the 7.5-kb human CCNA2 Gene (Cyclin A Family) at 4q25-q31 is transcribed into 1.8- and 2.7-kb mRNAs in all tissues tested (highest in testis). Cell cycle gene regulation is mediated by sequences surrounding the transcription start site; Rb protein is not required. HBV integration occurs within an intron. Accumulating during G2 and abruptly destroyed at mitosis, nuclear (at S phase) 432-amino acid 48.5-kD Cyclin A2 controls the cell cycle and promotes both G1/S and G2/M transitions. Inhibition of cyclin A synthesis or activity inhibits DNA synthesis. Highly conserved cyclins (proliferating cell nuclear antigens) regulate CDK kinases. Cyclin A interacts with CDK2 protein kinase and Ser/Thr kinase p34CDC2 (during G2/M) to form a holoenzyme complex; cyclin imparts substrate specificity to the complex. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C20958	CCNE2_Gene	Cyclin_Gene	CCNE2 Gene|CCNE2|CGE2|CYCE2|Cyclin E2 Gene	Upregulated by E6 and E7, the tissue expression pattern (G1/S peak) of conserved 15-kb human CCNE2 Gene (Cyclin E Family) at 8q22.1 is distinct from CCNE1 (Cyclin E1) and consistently elevated in tumor cell lines. Splice variants encode distinct nuclear Cyclin E2 isoforms: 1 (full-length 404-aa, 46.8-kD and 47% identical to E1), 2 (359-aa), and 3. Lacking 45 internal residues in the cyclin box, variant 2 does not bind CDK2. Frameshifted truncated variant 3 lacks 112 N-terminal residues. Imparting substrate specificity, short-lived regulatory E2 interacts with CDKs2/3, forms a holoenzyme, controls DNA synthesis, and regulates G1/S. CDK2 phosphorylation of E2 triggers release and likely ubiquitinated degradation. E2 interacts with CDK inhibitors CIP/KIP, which bind and inhibit E2/CDK2. Cyclins E1, E2 may be rate-limiting for G1 progression. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C20959	Cyclin-E2	Cyclin	Cyclin E2|CCNE2|CCNE2 Protein|G1/S-Specific Cyclin E2	Conserved human CCNE2 Gene (Cyclin E Subfamily) encodes distinct nuclear isoforms of Cyclin E2: 1 (full-length 404-aa, 46.8-kD and 47% identical to E1), 2 (359-aa), and 3. Lacking 45 internal residues in the cyclin box, variant 2 does not bind CDK2. Frameshifted truncated variant 3 lacks 112 N-terminal residues. Imparting substrate specificity, short-lived regulatory E2 interacts with CDKs2/3, forms a holoenzyme, controls DNA synthesis, and regulates G1/S. CDK2 phosphorylation of E2 triggers release and likely ubiquitinated degradation. E2 interacts with CDK inhibitors CIP/KIP, which bind and inhibit E2/CDK2. Cyclins E1, E2 may be rate-limiting for G1 progression. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C20960	CDC25A_Gene	Cell_Cycle_Gene	CDC25A Gene|CDC25A|Cell Division Cycle 25A Gene	The CDC25A gene encodes Cell Division Cycle 25A Protein (CDC25A), a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. This gene is an oncogene, although its exact role in oncogenesis has not been demonstrated. (RefSeq Summary)
C20961	Cell_Division_Cycle-25A_Protein	Cell_Cycle_Protein	Cell Division Cycle 25A Protein|CDC25A|CDC25A Protein|CDC25A Protein Tyrosine Phosphatase|Cell Division Cycle 25A|Cell Division Cycle 25A Protein Tyrosine Phosphatase	Cell Division Cycle 25A Protein (CDC25A), encodes by the CDC25A gene, is a member of the CDC25 family of phosphatases. CDC25A is required for progression from G1 to the S phase of the cell cycle. It activates the cyclin-dependent kinase CDC2 by removing two phosphate groups. CDC25A is specifically degraded in response to DNA damage, which prevents cells with chromosomal abnormalities from progressing through cell division. The CDC25A gene is an oncogene, although its exact role in oncogenesis has not been demonstrated. (RefSeq Summary)
C20962	MCL-1_Protien	Retired_Concepts	MCL-1 Protien
C20963	HRK_Protein	Retired_Concepts	HRK Protein
C20964	CHRM1_Gene	G_Protein-Coupled_Receptor_Gene	CHRM1 Gene|CHRM1|Cholinergic Receptor, Muscarinic 1 Gene|HM1|M1	This gene encodes muscarinic acetylcholine receptor M1.  The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13, with MDU1 proximally and COX8 distally located. (from RefSeq Summary)
C20965	Muscarinic_Acetylcholine_Receptor-M1	G_Protein-Coupled_Receptor	Muscarinic Acetylcholine Receptor M1|CHRM1|Cholinergic Receptor, Muscarinic 1	The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13, with MDU1 proximally and COX8 distally located. (from RefSeq Summary)
C20966	CHRM3_Gene	G_Protein-Coupled_Receptor_Gene	CHRM3 Gene|CHRM3|Cholinergic Receptor, Muscarinic 3 Gene|HM3	The gene encodes a muscarinic cholinergic receptor that belongs to a larger family of G protein-coupled receptors. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. (from RefSeq Summary)
C20967	Muscarinic_Acetylcholine_Receptor-M3	G_Protein-Coupled_Receptor	Muscarinic Acetylcholine Receptor M3|CHRM3|Cholinergic Receptor, Muscarinic 3	The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. (from RefSeq Summary)
C20968	CHRM5_Gene	G_Protein-Coupled_Receptor_Gene	CHRM5 Gene|CHRM5|Cholinergic Receptor, Muscarinic 5 Gene|HM5	This gene encodes muscarinic m5 acetylcholine receptor; which affects multiple pathways including phosphatidylinositol metabolism; member of the G protein-coupled receptor family. (Proteome Summary)
C20969	Muscarinic_Acetylcholine_Receptor-M5	G_Protein-Coupled_Receptor	Muscarinic Acetylcholine Receptor M5|CHRM5|Cholinergic Receptor, Muscarinic 5	Muscarinic m5 acetylcholine receptor; affects multiple pathways including phosphatidylinositol metabolism; member of the G protein-coupled receptor family. (Proteome Summary)
C20970	Epidermal_Growth_Factor_Superfamily_Protein	Growth_Factor	Epidermal Growth Factor Superfamily Protein|EGF Repeat Superfamily|Epidermal Growth Factor Repeat Superfamily	Many Epidermal Growth Factor Superfamily Proteins are extracellular signaling molecules (ligands) involved in control of target cell proliferation, cell survival, and cell differentiation. The EGF superfamily is characterized by having at least 6 cysteines residues that form disulphide bonds stacked in a ladder-like arrangement, in the order 1-3, 2-4, 5-6, and which are essential for the stability of the EGF fold. Often arranged as tandem repeats in extracellular proteins, the function of the domains remains unclear, but are thought to perform a structural role.
C20971	V-D-J_Recombination	Immunoglobulin_Gene_Rearrangement	V(D)J Recombination|Immunoglobulin V(D)J Rearrangement|V(D)J Rearrangement	By a cascade of temporally ordered translocation steps during B-cell development, V(D)J Recombination randomly joins discrete DNA segments that encode antibody variable-V, diversity-D, and joining-J, segments of the coding sequence for a single heavy or light chain gene. DNA recombinases recognize a palindromic heptamer and an AT-rich nonamer separated by a 12 or 23bp spacer recombination signal sequence (RSS) neighboring the coding regions; create double-stranded DNA breaks at the exon/RSS boundaries; excise intervening DNA; and ligate the DNA ends to create a contiguous reading frame.
C20972	Autoantigen	Antigen	Autoantigen	A key phenomenon in autoimmune diseases (affect about 10% of all populations) is the occurrence of circulating antibodies against the host. The targets of these autoantibodies, the autoantigens, are proteins, nucleic acids, or complexes of both. Some of them are assigned a marker function and are recognized by serum antibodies of patients suffering from a specific disease.
C20973	Amphiphysin	Regulatory_Protein	Amphiphysin|AMPH|Amp|Stiff-Mann Syndrome with Breast Cancer 128kD Autoantigen	Encoded by human AMPH Gene (Amphiphysin Family), 695-amino acid Amphiphysin isoforms of 128- and 108 kD are expressed in neurons, certain endocrine cells, and spermatocytes. The protein may regulate synaptic and endocrine exocytosis. Heterodimeric with AMPHL, AMPH is a non-intrinsic acidic membrane protein concentrated in nerve terminals and associated with the cytoplasmic face of synaptic vesicles. The N- and C-termini are highly conserved between chicken and human; the C-terminal region contains an SH3 domain. AMPH may control membrane associated cytoskeleton properties and protein dysfunction is associated with Stiff-Man Syndrome. (from Swiss-Prot, OMIM, and NCI)
C20974	Fatty_Acid-Binding_Protein-3	Ligand_Binding_Protein	Fatty Acid-Binding Protein 3|FABP3|Fatty Acid Binding Protein 11|Fatty Acid Binding Protein 3, Muscle And Heart (Mammary-Derived Growth Inhibitor)|Fatty Acid-Binding Protein 3, Muscle|Fatty Acid-Binding Protein, Heart|Fatty Acid-Binding Protein, Muscle And Heart|Fatty Acid-Binding Protein, Skeletal Muscle|H-FABP|Heart Fatty Acid-Binding Protein|M-FABP|MDGI|Mammary-Derived Growth Inhibitor|Muscle Fatty Acid-Binding Protein	Encoded by human FABP3 Gene (FABP/P2/CRBP/CRABP Transporter Family), Fatty Acid-Binding Protein 3 is a 132-amino acid 14.7 kD protein. Demonstrated in liver, heart, intestine, skeletal muscle, and brain, cytoplasmic FABPs are involved in uptake, intracellular metabolism, and/or transport of long-chain fatty acids and their acyl-CoA esters. Fatty Acid-Binding Protein 3 is likely involved in intracellular fatty acid transport, arrests the growth of mammary epithelial cells, and is involved in mammary gland differentiation. (from Swiss-Prot, OMIM, and NCI)
C20975	FABP1_Gene	FABP_Family_Gene	FABP1 Gene|FABP1|FABPL|Fatty Acid Binding Protein 1, Liver Gene|L-FABP	The FABP1 gene encodes Fatty Acid-Binding Protein 1, the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein binds free fatty acids and their coenzyme a derivatives, bilirubin, and some other small molecules in the cytoplasm. It may be involved in intracellular lipid transport. (from LocusLink and Swiss-Prot)
C20976	FABP4_Gene	FABP_Family_Gene	FABP4 Gene|FABP4|Fatty Acid Binding Protein 4, Adipocyte Gene	The FABP4 gene, encodes Fatty Acid-Binding Protein 4, which is a fatty acid binding protein found in adipocytes. This protein binds both long chain fatty acid and retinoic acid and is involved in lipid transport protein in adipocytes. (from LocusLink and Swiss-Prot)
C20977	FABP5_Gene	FABP_Family_Gene	FABP5 Gene|FABP5|Fatty Acid Binding Protein 5 (Psoriasis-Associated) Gene	Expressed in keratinocytes, human FABP5 Gene (FABP Family) encodes highly conserved 135-aa 15-kDa cytoplasmic Fatty Acid Binding Protein 5, which binds long-chain fatty acids with high specificity and other hydrophobic ligands. Likely involved in fatty acid uptake, transport, or metabolism and in keratinocyte differentiation, FABP5 has highest affinity for C18 chain lengths and decreasing affinity for decreasing chain lengths or chains with double bonds. (NCI)
C20978	Regulation_of_Exocytosis	Transport_Process	Regulation of Exocytosis	Regulation of Exocytosis consists of subcellular biochemical pathways and mechanisms that control release of cellular ingredients packaged in membrane-bound vesicles that fuse with the plasma membrane.
C20979	GTP_Binding	Molecular_Interaction	GTP Binding	GTP Binding is a molecular interaction between specific proteins (containing a GTP binding site) and guanosine 5-prime triphosphate during diverse cellular processes, such as RNA synthesis, translation, signal transduction, and cytoskeletal assembly.
C20980	BRCA1_Associated_RING_Domain-1_Protein	Apoptosis_Promoter	BRCA1 Associated RING Domain 1 Protein|BARD1|BRCA1 Associated RING Domain 1|BRCA1 Associated RING Domain Protein 1|BRCA1-Associated RING Domain 1	Encoded by human BARD1 Gene, nuclear BARD-1 Protein contains a RING zinc finger, three tandem ANK repeats, and two BRCT domains. BARD-1 heterodimerizes with BRCA1 via its N-terminal region and interacts with CSTF-50. BARD1/CSTF1 interacts with RNA Polymerase-2, which may inhibit pre-mRNA cleavage or polyadenylation. BARD-1/RNA Polymerase-2 holoenzyme may sense DNA damage; inhibition by CSTF1 may prevent erroneous polyadenylation of such RNAs. Processed during apoptosis, BARD-1 may mediate apoptosis; homodimers are more susceptible to proteolytic cleavage than BARD1/BRCA1. BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1; a stable BARD1/BRCA1 complex may be essential to BRCA1 tumor suppression. BARD-1 defects are found in primary breast, ovarian and uterine cancers. (from Swiss-Prot Q99728, OMIM 601593, and NCI)
C20981	Physiotherapy	Retired_Concepts	Physiotherapy
C20982	Tumor_Suppressor_Protein	Protein_Organized_by_Function	Tumor Suppressor Protein	Proteins involved in the regulation of cell growth and prevention of uncontrolled cell growth.
C20983	Serine_Hydrolase	Hydrolase	Serine Hydrolase	The serine hydrolases encoded by the serine hydrolase gene are a functional class of hydrolytic enzymes that contain a serine residue in their active site. The serine hydrolases can be grouped into subfamilies that contain closely related members in terms of substrate specificity or amino acid sequence similarity. (from OMIM 603156 and NCI)
C20984	Biphenyl_Hydrolase-Like_Protein	Serine_Hydrolase	Biphenyl Hydrolase-Like Protein|BPHL|Biphenyl Hydrolase-Like|Biphenyl Hydrolase-Related Protein|Breast Epithelial Mucin-Associated Antigen|Mucin-Associated Antigen|Valacyclovirase	Encoded by human BPHL Gene (Serine Hydrolase Family), 274-amino acid 30 kD Biphenyl Hydrolase-Related Protein, with structural similarity to enzymes involved in degradation of aromatic compounds, has a putative role in detoxification processes. Highest expression occurs in liver and kidney. Serine hydrolases contain serine in their active site and are grouped into subfamilies in terms of substrate specificity or amino acid sequence. (from Swiss-Prot Q00306, OMIM 603156, and NCI)
C20985	Ablation	Treatment	Ablation|ABL	Removal of a body part, pathway, or function by surgery, chemical destruction, surgical procedure, morbid process, or noxious substance. The concept also refers to separation or detachment; extirpation; eradication.
C20986	Trefoil_Factor-1	Retired_Concepts	Trefoil Factor 1|Breast Cancer Estrogen-Inducible Protein|Gastrointestinal Trefoil Protein pS2|TFF1|Tefoil Protein 1|Trefoil Protein 1	Encoded by human TFF1 Gene (Trefoil Family), 84-amino acid 9 kD (precursor) Trefoil Protein 1 (one trefoil domain) is expressed in stomach and duodenum. Trefoil proteins are stable secretory polypeptides expressed in gastrointestinal mucosa that have at least one trefoil motif (P-type domain), a 40-amino acid domain containing three conserved disulfides, and may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. The exact function has not been determined, but TFF1 may participate in gastrointestinal cell differentiation by delaying G1/S transition and reducing apoptosis. Strong expression is also found in the regenerative tissues surrounding ulcerous lesions of the gastrointestinal tract. (from Swiss-Prot P04155, OMIM 113710, and NCI)
C20987	CTNNB1_Gene	Signaling_Pathway_Gene	CTNNB1 Gene|CTNNB|CTNNB1|Catenin (Cadherin-Associated Protein), Beta 1, 88kDa Gene	Encodes Beta-catenin, an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete. (from OMIM)
C20988	Cell_Adhesion_Molecule_Gene	Ligand_Binding_Protein_Gene	Cell Adhesion Molecule Gene	Cell Adhesion Molecule Genes encode diverse extracellular (e.g., laminin) and cell surface (e.g., NCAM) glycoproteins involved in cell-cell and cell-extracellular matrix adhesion, recognition, activation, tissue integration, wound healing, morphogenesis, and cellular migration. (NCI)
C20989	Physical_Examination	Examination	Physical Examination|Assessment|Physical Assessment	A physical examination is a systemic evaluation of the body and its functions using visual inspection, palpation, percussion, and auscultation, aimed to determine the presence or absence of physical signs of disease or abnormality for individual's health assessment.
C20990	CD22_Gene	Cell_Adhesion_Molecule_Gene	CD22 Gene|BL-CAM|CD22|CD22 Antigen Gene|SIGLEC2	Expressed in pro-B cells until they differentiate into plasma cells, human CD22 Gene at 19q13.1 encodes heterodimeric cell surface glycoprotein CD22 antigen consisting of two subunits that arise by differential RNA processing of the same gene. The larger subunit is composed of an extracellular portion of seven Ig domains and a smaller subunit of five Ig domains. Structurally related to MAG, NCAM, and CEA, CD22 participates in B-cell adhesion to monocytes and T cells. Conserved ITIM motifs in inhibitory receptors are sites for phosphorylation by a SRC kinase and dephosphorylation by tyrosine phosphatase SHP1 or inositol phosphatase SHIP, transducing signals to distinct pathways. CD22 ITIMs interact with SHP1 and oppose activation mediated by the B-cell receptor. CD22 is a negative regulator of antigen receptor signaling. (NCI)
C20991	Cancer_Pain_Group	Personal_Attribute	Cancer Pain Group	Group I: Patients with acute cancer-related pain - associated with diagnosis and/or therapy.  Group II: Patients with chronic cancer-related pain - associated with cancer progression and/or therapy.  Group III: Patients with preexisting chronic pain and cancer pain.  Group IV: Patients with a history of drug addiction and cancer-related pain.  This includes those currently using, in treatment, and former users.  Group V: Dying patients with cancer-related pain. (Kanner)
C20992	Pain_Assessment	Examination	Pain Assessment|Pain Measurement	The evaluation of pain complaints.  Measurements should be objective on the part of the practitioner, based on subjective information from the patient.  Measurements may also be indirect, by such assessments as respiratory rate and effort, withdrawal, guarding, or other appropriate assessment techniques.
C20993	Clinical_Assessment_Tool	Document_Type	Clinical Assessment Tool	Any one of several evaluation/assessment tools used to ascertain a patient's condition or diagnosis.
C20994	ALCAM_Gene	Cell_Adhesion_Molecule_Gene	ALCAM Gene|ALCAM|Activated Leukocyte Cell Adhesion Molecule Gene|CD166|MEMD	ALCAM encodes a cell adhesion molecule which was expressed on mitogen-activated leukocytes and monocytes, fibroblasts, neurons, and tumor-derived cell lines but not on unactivated leukocytes.  ALCAM is a ligand for CD6, a receptor expressed on T-cells involved in cell adhesion interactions between thymocytes and thymic epithelial cells.  ALCAM/CD6 interactions may play a role in the binding of T- and B-cells to activated leukocytes.  ALCAM has five Ig domains and its amino acid sequence has significant homology to chicken neural adhesion molecule BEN/SC-1/DM-GRASP.  (from OMIM 601662 and NCI)
C20995	Pain_Assessment_Tool	Symptom_Specific_Assessment_Tool	Pain Assessment Tool	Any one of several evaluation/assessment tools used to ascertain a patient's level of pain.
C20996	Category_Rating_Scale	Retired_Concepts	Category Rating Scale|CRS	A pain rating scale that includes specific pain criteria and self-reported ratings based upon specific diagnoses.
C20997	PECAM1_Gene	Cell_Adhesion_Molecule_Gene	PECAM1 Gene|CD31|PECAM1|Platelet/Endothelial Cell Adhesion Molecule (CD31 Antigen) Gene	Expressed in endothelia, monocytes, platelets, and granulocytes, human PECAM1 Gene (CAM/Ig Family) encodes integral membrane glycoprotein CD31 Antigen, a cell adhesion molecule containing six extracellular Ig-like domains, a transmembrane domain, a cytoplasmic domain with six ITIMs, and concentrated at junctions between endothelial cells. PECAM1 appears involved in transendothelial migration of leukocytes, angiogenesis, integrin activation, and may inhibit platelet-collagen interactions. (NCI)
C20998	CEACAM5_Gene	Gene_with_Unknown_or_Unclassified_Function	CEACAM5 Gene|CD66e|CEA|CEACAM5|Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Gene	This gene belongs to the CEA family of genes. It encodes carcinoembryonic antigen-related cell adhesion molecule 5, a complex immunoreactive glycoprotein with a molecular weight of 180,000 comprising 60% carbohydrate. This gene comprises 9 exons encoding amino acids and 1 encoding a 3-prime untranslated fragment. Originally thought to be a specific antigen of the fetal digestive tract and adenocarcinoma of the colon, the gene product is known to occur normally in feces and pancreaticobiliary secretions and to appear in the plasma in a diverse group of neoplastic and non-neoplastic conditions. It is implicated as a facilitator of hepatic metastasis.
C20999	CD44_Gene	Cell_Adhesion_Molecule_Gene	CD44 Gene|CD44|CD44 Antigen (Homing Function and Indian Blood Group System) Gene|MDU3|Pgp1	Expressed in diverse cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts, human CD44 Gene at 11p13 encodes several alternative isoforms of CD44 Antigen, an acidic sulfated glycosylated integral membrane hyaluronate receptor that mediates cell-matrix adhesion, lymphocyte binding to endothelia, lymphocyte activation, macrophage activation, motility, lymph node homing, and immune cell cytokine release. CD44 also functions in a growth factor presentation mechanism necessary for limb development. (NCI)
C21000	Choices_and_Control	Clinical_or_Research_Activity	Choices and Control	In pediatrics (and some adult care), providing choices of treatment modalities, times of treatment, and other aspects of care within limits to give the patient a feeling of control and decreases feelings of helplessness associated with the treatment or care.
C21001	Cordotomy	Neurosurgical_Procedure|Pain_Management_Method	Cordotomy	Spinal cord section of lateral pathways to relieve pain. This procedure may be done open or percutaneous. (from Taber's)
C21002	Deafferentation	Neurosurgical_Procedure	Deafferentation|Denervation	Cutting off the afferent nerve supply.  Often performed to relieve pain. (Taber's).
C21003	CD34_Gene	Cell_Adhesion_Molecule_Gene	CD34 Gene|CD34|CD34 Antigen Gene|HPCA1	Likely involved in early hematopoiesis, human CD34 Gene at 1q32 encodes 385-aa monomeric CD34 Antigen, a glycosylated type I cell surface membrane protein adhesion antigen selectively expressed on hematopoietic progenitor cells. CD34 may mediate attachment to bone marrow extracellular matrix or stroma as a scaffold for attachment of lineage specific stem cell glycans to stromal or marrow lectins. The ratio of alternatively expressed CD34-T/CD34-F gene products increases with cell differentiation. CD34 is serine phosphorylated by PKC. Abnormal CD34 expression is associated with leukemogenesis. (NCI)
C21004	NCAM1_Gene	Cell_Adhesion_Molecule_Gene	NCAM1 Gene|CD56|NCAM|NCAM1|Neural Cell Adhesion Molecule 1 Gene	Widely and transiently expressed in early embryogenesis and then expressed in differentiated neurons, astrocytes, oligodendrocytes, and myotubes, human NCAM1 Gene (Ig Superfamily) encodes membrane-bound cell surface glycoprotein Neural Cell Adhesion Molecule, which may contain a covalent phospholipid moiety and binds to a variety of cell adhesion proteins to mediate cell-cell and cell-matrix adhesion through homophilic and heterophilic interaction. Important in morphogenetic formation of cell collectives, NCAM1 can mediate homophilic cell aggregation and diverse contact-mediated interactions involved in neuronal adhesion, guidance, and differentiation. Four main isoforms exist, but there are many variants derived from alternative splicing and post-translational modifications. (NCI)
C21005	Dermatome_Map	Clinical_Assessment_Tool	Dermatome Map	A visual representation of the bands of skin innervated by the sensory nerves used for assessment.
C21006	ICAM1_Gene	Cell_Adhesion_Molecule_Gene	ICAM1 Gene|BB2|CD54|ICAM-1 Gene|ICAM1|Intercellular Adhesion Molecule 1 (CD54), Human Rhinovirus Receptor Gene	Induced by gamma-interferon, human ICAM1 Gene at 19p13.3-p13.2 encodes Intercellular Adhesion Molecule 1, a cell-surface ligand for LFA-1, a cell surface receptor constitutively expressed on some tissues and induced on others in inflammation. ICAM-1 is required for neutrophil migration, leukocyte adhesion, and inflammation. ICAM-1/LFA-1 interaction provides accessory adhesion signals in many immune interactions between T- and B-lymphocytes and between cytotoxic T-cells and their targets. ICAM-1 protein is the major human rhinovirus receptor. (NCI)
C21007	Disability	Conceptual_Entities	Disability|Handicap|Infirmity	Any physical, mental, or functional impairment that limits a major activity.  It may be partial or complete. (Taber's)
C21008	ICAM2_Gene	Cell_Adhesion_Molecule_Gene	ICAM2 Gene|CD102|ICAM2|Intercellular Adhesion Molecule 2 Gene	Human ICAM2 Gene at 17q23-q25 encodes Intercellular Adhesion Molecule 2, a second LFA-1 ligand and integral membrane protein with two Ig-like domains.  It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. (NCI)
C21009	Discectomy	Orthopedic_Surgical_Procedure	Discectomy	Surgical excision of an intervertebral disc.  Often performed for pain relief.
C21010	Discomfort_Scale_for_Patients_with_Dementia_of_the_Alzheimer_s_Type	Pain_Assessment_Tool	Discomfort Scale for Patients with Dementia of the Alzheimer's Type|DS-DAT	An indirect pain assessment scale used by nurses and other professionals to evaluate level of pain/discomfort in demented or otherwise uncommunicative patients. (Kanner).
C21011	Distraction_and_Attention	Pain_Management_Method	Distraction and Attention	A method of pain control used primarily in pediatrics that combines distracting the patient's attention away from the painful procedure or circumstance.
C21012	Electroanalgesia	Pain_Management_Method	Electroanalgesia|Neuroaugmentation Techniques	Application of electrical stimulation to the spinal cord, deep brain, peripheral nerves, and Chinese acupoints in an effort to relieve pain.  It is often used in place of or to augment the effectiveness of analgesics. There are many different types of electroanalgesia with varying levels of effectiveness and invasiveness. (White, Li, and Chiu)
C21013	ICAM3_Gene	Cell_Adhesion_Molecule_Gene	ICAM3 Gene|CD50|ICAM3|Intercellular Adhesion Molecule 3 Gene	Human ICAM3 Gene at 19p13.3-p13.2 encodes Intercellular Adhesion Molecule 3, a ligand for LFA-1, a major receptor of T-cells, B-cells, and granulocytes that mediates the leukocyte adhesion reactions underlying many immune functions.  The interaction of LFA-1 with ICAM provides essential accessory adhesion signals in many immune interactions, including those between T- and B-lymphocytes and cytotoxic T-cells and their targets.  ICAM3 is potentially the most important ligand for LFA-1 in the initiation of the immune response.  ICAM3 is closely related to ICAM1, consists of five Ig domains, and binds LFA-1 through its two N-terminal domains.  (from OMIM 146631 and NCI)
C21015	DBCCR1_Protein	Protein_with_Unknown_or_Unclassified_Function	DBCCR1 Protein|DBC1|DBCCR1|Deleted in Bladder Cancer Chromosome Region Candidate 1|FAM5A	Encoded by human tumor suppressor DBCCR1 Gene, 761-amino acid 88.9-kD DBCCR1 Protein contains a MAC/Perforin domain, seven potential N-glycosylation sites, four N-myristoylation sites, and thirty phosphorylation sites. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C21016	CD58_Gene	Cell_Adhesion_Molecule_Gene	CD58 Gene|CD58|LFA-3|LFA3 Gene|Lymphocyte Function-Associated Antigen 3 Gene|MSK2 Gene	The CD58 gene encodes Lymphocyte Function-Associated Antigen-3 (LFA-3), which is a member of the Ig gene superfamily and a ligand for CD2 via heterophilic adhesion between the N-terminal domains. LFA-3 glycoproteins have a wide distribution on hematopoietic and non-hematopoietic cells and are strongly expressed on macrophages. Interaction between CD2 and its counter-receptor, LFA-3, on opposing cells optimizes immune recognition, facilitating contacts between helper T-lymphocytes and antigen-presenting cells as well as between cytolytic effectors and target cells. (from OMIM 153420 and NCI)
C21017	Protein_Acetylation	Post-Translational_Modification	Protein Acetylation|Acetylation	The covalent chemical or post-translational biochemical addition of an acetyl group(s) to a peptide or protein. (NCI)
C21018	Protein_Dephosphorylation	Post-Translational_Modification	Protein Dephosphorylation|Dephosphorylation	The covalent chemical or post-translational biochemical removal of a phosphate group(s) from a peptide or protein, by phosphatases. (NCI)
C21019	Suppression_of_Cancer_Cell_Invasion	Cell_Movement_Process	Suppression of Cancer Cell Invasion	Suppression of Cancer Cell Invasion involves the inhibition of infiltration and destruction of surrounding tissue by malignant cells.
C21020	P-Cadherin	Cadherin	P-Cadherin|CDH3|Cadherin-3|Placental Cadherin|Placental Calcium-Dependent Adhesion Protein	Encoded by human CDH3 Gene (CDH Family), 829-amino acid 91 kD (precursor) Placental Cadherin is a homophilic Ca(2+)-dependent cell-cell adhesion type I membrane glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Aberrant expression is observed in cervical adenocarcinomas. Hypotrichosis with juvenile macular dystrophy is caused by production of a truncated protein resulting from a homozygous nucleotide deletion. (from SWISS-PROT, OMIM, and NCI)
C21021	VE-Cadherin	Cadherin	VE-Cadherin|7B4 Antigen|CD144 Antigen|CDH5|Cadherin-5|Vascular Endothelial Cadherin|Vascular Endothelial Cadherin 1	Encoded by human CDH5 Gene (CDH Family), 784-amino acid 87.5 kD (precursor) Vascular Endothelial Cadherin is a Ca(2+)-dependent homophilic endothelial cell-cell adhesion type I membrane glycoprotein composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Expressed specifically in endothelial cells and brain, VE-Cadherin is found mainly at cell-cell boundaries, associated with intercellular junctions. CDH5 may play a role in endothelial cell cohesion and organization of intercellular junctions. CDH5/beta-catenin signaling may control endothelial survival. CDH5 associates with alpha-catenin, forming a link to the cytoskeleton. (from LocusLink, SWISS-PROT, OMIM, and NCI)
C21022	H-Cadherin	Cadherin	H-Cadherin|CDH13|Cadherin-13|Heart Cadherin|P105|T-Cad|T-Cadherin|Truncated-Cadherin	Encoded by human CDH13 Gene (CDH Family), 713-amino acid 78 kD (precursor) putative tumor suppressor Cadherin 13 is a Ca(2+)-dependent cell-cell adhesion glycoprotein composed of five extracellular cadherin repeats. H-Cadherin lacks the conserved cytoplasmic region and is attached to the membrane by a GPI-anchor, unlike typical cadherins. Highest expression is observed in the heart. CNS expression is higher in adult than in fetus.  A putative mediator of cell interactions, this cadherin may inhibit neural cell growth. (from SWISS-PROT, OMIM, LocusLink, and NCI)
C21023	Spinal_Cord_Stimulation	Electroanalgesia	Spinal Cord Stimulation|SCS	A highly invasive form of electroanalgesia used to treat various chronic pain syndromes, which resist treatment by more common means.  It is also used to treat peripheral ischemia, peripheral vascular disease, complex regional pain syndrome, intractable angina, chronic mesenteric ischemia, and diabetic peripheral arterial occlusive disease. (from White, Li, and Chiu)
C21024	Deep_Brain_Stimulation	Electroanalgesia	Deep Brain Stimulation|DBS	A highly invasive form of electroanalgesia mainly used in the management of debilitating chronic pain syndromes after all other less invasive therapeutic modalities (including SCS) have failed. (White, Li, and Chiu)
C21025	Peripheral_Nerve_Stimulation	Electroanalgesia	Peripheral Nerve Stimulation|PNS	A minimally invasive form of electroanalgesia often used in neuropathic pain.  For best effect, the stimulation is applied proximally to the site of the nerve lesion. (from White, Li, and Chiu)
C21026	Peripheral_Electronic_Nerve_Stimulation	Electroanalgesia	Peripheral Electronic Nerve Stimulation|PENS	A minimally invasive form of electroanalgesia involving stimulation of the dermatomal bands proximal to the affected area.  It is often used in the treatment of intractable chronic lower back pain, cancer pain, and other painful disorders. (from White, Li, and Chiu)
C21027	Percutaneous_Neuromodulation_Therapy	Electroanalgesia	Percutaneous Neuromodulation Therapy|PNT	A minimally invasive form of electroanalgesia, similar to PENS but using deeper needles depths, that is used to treat intractable chronic lower back pain, cancer pain, and other painful disorders. (from White, Li, and Chiu)
C21028	Transcutaneous_Acupoint_Electrical_Stimulation	Electroanalgesia	Transcutaneous Acupoint Electrical Stimulation|TAES	A non-invasive form of TENS where the gel pads are placed on acupoints and stimulation is alternated between low-intensity/high frequency and high-intensity/low frequency (dense disperse). (from White, Li, and Chiu)
C21029	H-Wave_Therapy	Electroanalgesia	H-Wave Therapy|HWT	A non-invasive form of electroanalgesia produces a direct, localized effect on the conduction of underlying peripheral nerves.  It is often used for dental analgesia, treatment of acute musculoskeletal injuries, postoperative pain, local analgesia, and in treatment of diabetic patients with peripheral neuropathic pain. (from White, Li, and Chiu)
C21030	Inferential_Current_Treatment	Electroanalgesia	Inferential Current Treatment|ICT	A non-invasive form of electroanalgesia, based on TENS, that uses the principle of amplitude modulation to decrease the discomfort of stimulating deeper tissues when using transcutaneously applied electrical current.  It is often used in physiotherapy and rehabilitation settings. (White, Li, and Chiu)
C21031	Piezo-Electric_Current_Therapy	Electroanalgesia	Piezo-Electric Current Therapy|PECT	A minimally invasive, experimental form of electroanalgesia based upon the theory that rapid electrical stimulation of A-delta and C pain fibers can lead to nociceptive afferent input depression.  This may be due to exogenous endorphin production release after stimulation. (White, Li, and Chiu)
C21032	Transcutaneous_Electrical_Nerve_Stimulation	Electroanalgesia	Transcutaneous Electrical Nerve Stimulation|TENS|transcutaneous electric nerve stimulation	A non-invasive form of electroanalgesia that uses conductive gel pads to transmit electrical energy from an external stimulator to peripheral nerves.  There are two forms: low-intensity/high frequency and high-intensity/low frequency (dense disperse).  The method of action is suspected to involve release of endogenous opioids.  It is often used for peripheral neuropathic pain. (from White, Li, and Chiu)
C21033	ITGAL_Gene	Cell_Adhesion_Molecule_Gene	ITGAL Gene|CD11A|ITGAL|Integrin, Alpha L (Antigen CD11A (p180), Lymphocyte Function-Associated Antigen 1; Alpha Polypeptide) Gene|LFA-1|LFA1A	Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAL encodes the integrin alpha L chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. (from LocusLink)
C21034	Glycosylation	Biochemical_Reaction	Glycosylation|Metabolic Glycosylation	The covalent chemical or biochemical addition of carbohydrate or glycosyl groups to other chemicals, by glycosyl transferases.
C21035	Protein_Methylation	Post-Translational_Modification	Protein Methylation|Methylation	Post-translational enzymatic covalent addition of a methyl group(s) to a peptide or protein.
C21036	Facial_Affective_Scale	Pain_Assessment_Tool	Facial Affective Scale|FAS|Faces Scale	A pain measurement tool that uses drawn representations of cartoon faces (of the "smiley face" variety) that rage from frowning and grimacing to smiling heartily.  These scales can be used objectively by the practitioner or a family member to evaluate the pain expression on the patient's face, or subjectively by having the patient point to the representation that most closely resembles his or her current level of pain.  This scale is often used in pediatrics and geriatrics.
C21037	Fleming_Method_Relaxation	Mind-Body_Intervention	Fleming Method Relaxation|Fleming Method	A relaxation technique used in management of stress, pain, and blood pressure.  Its focus is on spontaneous movement, concentration, visual and auditory objectivity, controlled self-consciousness, and responsiveness to interpersonal relationships. (from Fleming)
C21038	Molecular_Folding	Retired_Concepts	Molecular Folding
C21039	Nucleic_Acid_Folding	Biophysical_Process	Nucleic Acid Folding	Process by which a nucleic acid macromolecule assumes an energetically favorable three-dimensional conformation as a result of intrinsic and extrinsic atomic physical forces. (NCI)
C21040	Cell_Signaling_Process	Biochemical_Process	Cell Signaling Process|Cell Communication Process|Subcellular Signaling Process	Any subcellular or molecular event, process, or condition involved in receptor-ligand interaction, transduction, processing, integration, discrimination, transmission, or response to a cell communication event, process, or condition. (NCI)
C21041	SELP_Gene	Cell_Adhesion_Molecule_Gene	SELP Gene|CD62|CD62P|GMP140|GRMP|PADGEM|PSEL|SELP|Selectin P (Granule Membrane Protein 140kDa, Antigen CD62) Gene|Selectin P Gene	P-Selectin is a cell surface adhesion molecule that mediates the interaction of activated endothelial cells or platelets with neutrophils and monocytes.  The protein is detected in megakaryocytes and platelets, as well as in vascular endothelial cells, but not in other cell types.  In endothelia, the protein is localized to the membranes of Weibel-Palade bodies, intracellular storage granules for von Willebrand factor.  CD24 is a ligand for P-selectin.  Sorting nexin-17 interacts with the cytosolic domain of P-selectin and may function in the intracellular trafficking of P-selectin.  (from OMIM 173610 and NCI)
C21042	Group_Therapy	Psychotherapy	Group Therapy	A form of psychiatric treatment in which six to eight patients meet a specific number of times with a therapist.  The value of this type of therapy is the opportunity for gaining insight from others into one's life experience. (Taber's)
C21043	SELE_Gene	Cell_Adhesion_Molecule_Gene	SELE Gene|CD62E|CD62E Gene|ELAM|ELAM1|ESEL|Endothelial Leukocyte Adhesion Molecule 1 Gene|LECAM2|SELE|Selectin E (Endothelial Adhesion Molecule 1) Gene|Selectin E Gene	Expressed by cytokine-induced endothelia, single copy 13-kb human SELE Gene (Selectin Family) at 1q22-q25 contains 14 exons encoding 610-aa 66.5-kD E-Selectin precursor, a type I membrane protein with features homologous to LYAM1: a C-type lectin domain, an EGF-like domain, six cysteine-containing SCR (sushi) domains. Likely having an evolutionary history with complement binding protein genes and neighboring LYAM1 and GRMP, ELAM1 exon-intron boundaries correlate with putative functional regions of the protein. Mediating cell adhesion binding of endothelial cells to leukocytes, such as Neutrophils, during inflammatory responses, ELAM1 recognizes glycolipid polylactosamine derivatives and may be involved in the pathogenesis of atherosclerosis. An aa149 polymorphism is associated with higher risk of coronary artery disease and ELAM1 is a diagnostic indicator of glaucoma. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C21044	Cell_Death_Signaling_Process	Signal_Transduction	Cell Death Signaling Process|Cell Death Signaling	Any subcellular or molecular event, process, or condition involved in reception, transduction, processing, integration, discrimination, transmission, dissemination, or response to a cell communication event, process, or condition related to cell death. (NCI)
C21045	Coagulation_Process	Host_Defense_Mechanism	Coagulation Process|Coagulation-Related Process	Any process, condition, or event involved in blood coagulation. (NCI)
C21046	SELL_Gene	Cell_Adhesion_Molecule_Gene	SELL Gene|CD62L|HLHRC|LAM-1|LECAM1|LNHR|LSEL|LYAM-1|LYAM1|SELL|Selectin L (Lymphocyte Adhesion Molecule 1) Gene|Selectin L Gene|TQ-1	L-Selectin is a cell surface glycoprotein adhesion molecule that serves as a homing receptor for lymphocytes to lymph node high endothelial venules.  The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to C3/C4 binding protein consensus repeat units.  L-Selectin may also play a role in neutrophil adhesion to endothelium at sites of inflammation.  A tissue-specific mucin-like endothelial glycoprotein appears to function as ligand for L-selectin, in the role of scaffold that presents carbohydrates to the L-selectin lectin domain.  PLAUR is directly associated with the carbohydrate-binding domain of L-selectin in the membrane of neutrophils, an association analogous to that between PLAUR and beta-2 integrins.  (from OMIM 153240 and NCI)
C21047	VTN_Gene	Cell_Adhesion_Molecule_Gene	VTN Gene|V75|VNT|VTN|Vitronectin (Serum Spreading Factor, Somatomedin B, Complement S-Protein) Gene|Vitronectin Gene	The protein encoded by this gene is a member of the pexin family. It is found in serum and tissues and promotes cell adhesion and spreading, inhibits the membrane-damaging effect of the terminal cytolytic complement pathway, and binds to several serpin serine protease inhibitors. It is a secreted protein and exists in either a single chain form or a clipped, two chain form held together by a disulfide bond. (LocusLink)
C21048	DNA_Replication_Proofreading	DNA_Repair	DNA Replication Proofreading|DNA Proofreading|Proofreading of DNA Replication	A function of the mismatch repair (MMR) system that promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication. This function is critically dependent on the assembly of multimeric complexes involved in mismatch recognition and signal transduction to downstream repair events.
C21049	Gene_Expression_Process	Biochemical_Process	Gene Expression Process	Any subcellular or molecular event or process specifically, primarily, and directly designed for and involved in the production of mature functional biomolecular products encoded by a gene.
C21050	Gene_Regulation	Gene_Expression_Process	Gene Regulation|Gene Expression Regulation|Gene Regulation Process|Regulation of Gene Expression	1) Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action at the level of transcription or translation. These processes include gene activation and genetic induction.  2) In relation to the structure and organization of a gene; refers to the regulatory elements that segregate with, and act on, a gene in a cis fashion.
C21051	Epigenetic_Process	Gene_Regulation	Epigenetic Process|Epigenetic Change|Epigenetic Mechanism|Epigenetics	Changes in the regulation of the expression of gene activity without alteration of genetic structure.
C21052	Post-Transcriptional_Regulation_Process	Retired_Concepts	Post-Transcriptional Regulation Process
C21053	RNA_Polyadenylation_Regulation	Post-Transcriptional_Regulation	RNA Polyadenylation Regulation|Regulation of RNA Polyadenylation	RNA Polyadenylation Regulation involves cellular events or activities that directly control the covalent addition of polyadenylyl sequences to the 3 prime end of a nascent mRNA transcript.
C21054	RNA_Polyadenylation_Inhibition	RNA_Polyadenylation_Regulation	RNA Polyadenylation Inhibition	RNA Polyadenylation Inhibition involves events or activities that directly hinder the covalent addition of polyadenylyl sequences to the 3 prime end of a nascent mRNA transcript.
C21055	Impairment	Conceptual_Entities	Impairment	Loss or abnormality of psychological, physiological, or anatomic structure or function. (Kanner)
C21056	Interpretive_Therapy	Psychotherapy	Interpretive Therapy	Psychotherapy of the Freudian school.  In this form of psychotherapy, symbols from the patient's verbalizations, dreams, and interactions are interpreted for meaning in their everyday lives.  Some mental health professionals find this very helpful in defining effective methods for treating chronic pain and pain syndromes.
C21057	Isometric_Exercise	Exercise	Isometric Exercise|Isometrics|Muscle-Setting Exercise|Static Exercise	An exercise that is performed by exerting force against an immovable object or by holding an object in a static position.  This exercise helps to prevent muscle atrophy during the acute pain phase or when other exercises are contradicted. (Kanner)
C21058	Isotonic_Exercise	Exercise	Isotonic Exercise|Isotonics	An exercise that involves the movement of a constant weight or load through a specified range of motion.  This exercise can build strength and endurance.
C21059	Isokinetic_Exercise	Exercise	Isokinetic Exercise|Isokinetics	An exercise that involves movement at a constant rate with a variable force throughout a specified range of motion.  The advantage of this exercise is that it stresses the muscle being used throughout the entire range. (Kanner)
C21060	Intravenous_Patient-Controlled_Analgesia	Pain_Therapy	Intravenous Patient-Controlled Analgesia|IV PCA|PCA|Patient-Controlled Analgesia|patient-controlled analgesia	A method of intravenous narcotic analgesic delivery that uses a pump or similar delivery system that allows the patient, or in the absence of the patient's ability to do so the patient's nurse or family members, to administer predetermined doses of analgesic as needed to maintain adequate pain control.  This method allows the patient and/or family to have increased autonomy.  Further, research has shown improved pain control and reductions in narcotics necessary to maintain pain control to be associated with this delivery method.
C21061	Laminectomy	Head_and_Neck_Surgery	Laminectomy	The excision of a vertebral posterior arch, usually to remove a lesion or herniated disk. (Taber's)
C21062	Actinotherapy	Pain_Therapy	Actinotherapy|Light Therapy	The use of light at various frequencies to produce thermal analgesia and prevent damage to nerve and muscle tissue.  It includes ultraviolet, infrared, and low-emission laser frequencies.
C21063	Low_Emission_Laser_Therapy	Actinotherapy	Low Emission Laser Therapy|Low-Emission Laser Therapy	Use of low-emission laser therapy has been shown to reduce pain when applied directly to the painful area or to acupuncture points.  The mechanism is unknown.  It has also been shown to postpone post-traumatic neural degeneration. (from Kanner)
C21064	Protein_Turnover	Catabolism	Protein Turnover|Protein Degradation|Protein Degradation, Metabolic	The normal "downside" of protein steady state metabolism in cells, involving conjugation, transport, oxidation, and proteolysis; not to be confuse with proteolysis, which applies only to peptide bond hydrolysis.
C21065	Cell_Stress_Process	Pathologic_Process	Cell Stress Process|Cell Stress-Related Process	Cellular or subcellular processes involved in disturbance or restoration of a homeostatic condition. (NCI)
C21066	Cellular_Stress	Cell_Stress_Process	Cellular Stress	Cellular or subcellular processes involved with significant disturbance from a homeostatic condition. (NCI)
C21067	Cellular_Stress_Response	Cell_Stress_Process	Cellular Stress Response	Cellular or subcellular processes involved in restoration of a homeostatic condition.
C21068	DNA_Sequence_Alteration	Molecular_Sequence_Alteration	DNA Sequence Alteration	Any subcellular or molecular event, process, or condition that produces a divergence from the usual wild-type, germline, or pre-existing condition in the primary sequence of a DNA molecule. (NCI)
C21069	DNA_Sequence_Rearrangement	DNA_Sequence_Alteration	DNA Sequence Rearrangement|Rearrangement	Any subcellular or molecular event, process, or condition that produces a divergence from the usual wild-type, germline, or pre-existing order of nucleotides in the primary sequence of a DNA molecule. (NCI)
C21070	Protein_Sequence_Alteration	Molecular_Sequence_Alteration	Protein Sequence Alteration	Any subcellular or molecular event, process, or condition that produces a divergence from the usual wild-type condition in the primary sequence of a peptide or protein molecule. (NCI)
C21071	Multidisciplinary_Pain_Treatment_Center	Healthcare_Facility	Multidisciplinary Pain Treatment Center	Free-standing or institution-based clinics devoted to pain management from a multidisciplinary perspective.  Team members usually include physicians, nurses, social workers, physical therapists, occupational therapists, respiratory therapists, pharmacists, and the patient's family and friends, who approach the patient's needs as a team.
C21072	Neural_Block	Anesthesia_Procedure	Neural Block|Nerve Block|Neural Blockade|nerve block	A procedure in which medicine is injected directly into or around a nerve or into the spine to block pain.
C21073	Neuraxial_Opioid_Analgesia	Anesthesia_Procedure	Neuraxial Opioid Analgesia	Analgesic delivery into the spinal axis.
C21074	Neurologic_Process	Organismal_Process	Neurologic Process	A biological function or activity involving the cells or tissue components of the nervous system.
C21075	Nociception	Sensory_Process	Nociception	The stimulus-response process involving the stimulation of peripheral pain-carrying nerve fibers (e.g., C-fibers, A-delta fibers) and the transmission of impulses along peripheral nerves of the central nervous system, where the stimulus is perceived as pain. (Taber's)
C21076	Nociceptive_Impulse	Retired_Concepts	Nociceptive Impulse	Impulse giving rise to sensations of pain. (Taber's)
C21077	Nociceptive_Reflex	Intercellular_Communication_Process	Nociceptive Reflex	A reflex initiated by a painful stimulus. (Taber's)
C21078	Nociceptive_Stimulus	Biochemical_Process	Nociceptive Stimulus|Nociceptive Impulse	A painful and usually injurious stimulus. (Taber's)
C21079	Transport_Process	Biochemical_Process	Transport Process|Molecular Transport	Any subcellular or molecular process involved in translocation of a biological entity, such as a macromolecule, from one site or compartment to another. (NCI)
C21080	Replication-Associated_Process	Biochemical_Process	Replication-Associated Process|Replication Process	Any subcellular or molecular event, process, or condition immediately and directly involved in the molecular process of DNA replication or preparation for chromosome transfer to daughter cells. (NCI)
C21081	Growth_Arrest-Specific_Protein-8	Protein_with_Unknown_or_Unclassified_Function	Growth Arrest-Specific Protein 8|GAS11|GAS8|Growth Arrest Specific 11|Growth Arrest Specific 11 Protein	Encoded by human GAS8 Gene, 56 kD Growth Arrest-Specific Protein 8 is a ubiquitous 478-amino acid putative tumor suppressor protein. GAS8 amino acid sequence is 96% identical to the mouse homolog, expressed during growth arrest. (NCI)
C21082	Numeric_Rating_Scale	Pain_Assessment_Tool	Numeric Rating Scale|Numerical Scale	A pain rating scale that attempts objectivity by reliance on a person's ability to rate pain on a scale of 0 to 5, 10, or 100, where the lowest number in the scale represents no pain and the highest number represents the worst imaginable pain.
C21083	Opioid_Rotation	Pharmacologic_Management	Opioid Rotation|Narcotic Rotation|Narcotic Substitution|Narcotic Switching|Opioid Substitution|Opioid Switching	Shifting from one opiate to another to maintain effectiveness in analgesia while minimizing the side-effect profile.
C21084	Pain_Map	Pain_Assessment_Tool	Pain Map|Body Map	Using a drawn representation of the body, patients who are unable to speak mark areas where they feel pain.  Some practitioners use colored pencils or crayons to allow patients to color code areas of more or less severe pain.
C21085	Pain_Threshold	Personal_Attribute	Pain Threshold|pain threshold	The minimum level of stimulation of a body part that a person will perceive as being noxious or unpleasant. (Taber's)
C21086	Pain_Tolerance	Personal_Attribute	Pain Tolerance|Pain Tolerance Level	The degree of pain an individual can withstand. (Taber's)
C21087	Infusion_Technique	Infusion	Infusion Technique
C21088	Parenteral_Infusion	Infusion_Technique	Parenteral Infusion|IV Infusion|Intravenous Infusion	Administration of medications or nutrients directly into the venous system.
C21089	Patient_Self-Report	Clinical_Assessment_Tool	Patient Self-Report|Self Report|Self-Report	Subjective reports made by a patient.
C21090	Pharmacologic_Management	Cancer_Pain_Management	Pharmacologic Management|Analgesic Management|Medication Management	A health/illness/pain management principle specifically directed at the management of pharmacologic agents in maximizing beneficial outcomes and minimizing unfavorable effects.
C21091	TNC_Gene	Regulatory_Gene	TNC Gene|HXB|TN|TNC|Tenascin C (Hexabrachion) Gene	Spatially and temporally expressed in many developing organs and induced by serum as well as TGF-beta, human TNC Gene encodes 6 alternative isoforms of secreted multidomain Tenascin C, containing 15 EGF-like repeats, 15 C-terminal fibronectin type III domains, and a fibrinogen C-terminal domain. A ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-v/beta-3 and alpha-v/beta-6, this hexameric extracellular matrix substrate-adhesion glycoprotein appears to inhibit cell migration and promote cell attachment. Homotrimer subunits may be formed in the triple coiled-coil region and stabilized by disulfide-links at both ends. Two of such half-hexabrachions may be disulfide linked within the central globule. (NCI)
C21092	HSPB1_Gene	Chaperone_Gene	HSPB1 Gene|HSP27|HSPB1|Heat Shock 27kD Protein 1 Gene|Heat-Shock Protein 27 Gene	The HSPB1 gene at 7q11.23 encodes Heat Shock 27 kD Protein 1, which is involved in stress resistance and actin organization. This protein belongs to the small heat shock protein (HSP20) family. It associates with alpha- and beta-tubulin and microtubules. It is localized in the cytoplasm in interphase cells and colocalizes with mitotic spindles in mitotic cells. It translocates to the nucleus during heat shock. It is expressed in response to environmental stresses such as heat shock, or estrogen stimulation in MCF-7 cells. This protein is phosphorylated in MCF-7 cells on exposure to protein kinase C activators and heat shock. (from Swiss-Prot and NCI)
C21093	Preemptive_Analgesia	Pharmacological_Treatment	Preemptive Analgesia	Treatment with analgesics on a schedule or in advance of the return of pain in an attempt to minimize peaks in the pain cycle.
C21095	Quality_Adjusted_Life_Years	Vital_Statistics	Quality Adjusted Life Years|QALY	A measure of the health of a population that combines an assessment of both mortality and disability. (Taber's)
C21096	Cell_Motility_Process	Retired_Concepts	Cell Motility Process	Any of the processes required to bring about cell motility.
C21097	Sedation	Anesthesia_Procedure	Sedation	The process of allaying nervous excitement or the state of being calmed. (Taber's)
C21098	F3_Gene	Coagulation_Factor_Gene	F3 Gene|CD142|Coagulation Factor III (Thromboplastin, Tissue Factor) Gene|Coagulation Factor III Gene|F3|TF|TFA|Thromboplastin Gene	This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. (LocusLink)
C21099	Cell_Viability_Process	Cellular_Process	Cell Viability Process	A cellular process that directly affects the ability of a cell to proliferate, grow, divide, or repair damaged cell components. (NCI)
C21100	Social_Isolation	Social_Concepts	Social Isolation	A condition in which an individual feels or is made to feel as though he or she has no place within society.  This is often the case with persons who have inadequate support systems or who suffer from stigmatized disease, such as AIDS and mental illness.
C21101	Cell_Growth_Process	Cell_Viability_Process	Cell Growth Process	Complex cellular phenomena occurring apart from cell division that support cell viability and differentiated cell function. (NCI)
C21102	Cell_Division_Process	Cellular_Process	Cell Division Process	A cellular mechanism directly involved in the process of cell division. (NCI)
C21103	Hyaluronan-Mediated_Motility_Receptor	Receptor	Hyaluronan-Mediated Motility Receptor|CD168 Antigen|HMMR|Intracellular Hyaluronic Acid Binding Protein|Receptor for Hyaluronan-Mediated Motility	Encoded by human HMMR Gene and expressed in normal breast tissue, the 724-amino acid 84 kD Hyaluronan-Mediated Motility Receptor is similar to murine Hmmr. A subunit of the HARC complex, the hyaluronan receptor is required for cell motility and may regulate ERK activity. Phosphorylation of several proteins, including pp125-FAK, occurs when Hyaluronan binds HMMR; FAK phosphorylation is necessary for disassembly of focal contacts and motility. HMMR is up regulated in response to wound healing. (from Swiss-Prot, OMIM, and NCI)
C21104	Pain_Origin	Pain_Attribute	Pain Origin	The bodily region or diagnosis from which pain is felt.
C21105	Pain_Attribute	Properties_or_Attributes	Pain Attribute
C21106	Pain_Nature	Pain_Attribute	Pain Nature	The occurrence of the pain, whether it is incidental or continuous.
C21107	Previous_Pain_Treatment_Assessment	Pain_Assessment	Previous Pain Treatment Assessment|Previous Pain Treatment	The extent to which previous pain treatments were successful and the treatment regimens used, including narcotics, alternative/complimentary treatments, etc.
C21108	M-Phase_Substage	Cell_Cycle_Stage	M Phase Substage	Any one of the major conceptual subdivisions, based on characteristic cytological and biochemical events, during M Phase of the eukaryotic cell cycle that occur in the order Prophase, Metaphase, Anaphase, and Telophase and lead toward nuclear division. (NCI)
C21109	Supportive_Therapy	Retired_Concepts	Supportive Therapy	Supportive therapy may provide a patient with friendship, encouragement, practical advice such as access to community resources or how to develop a more active social life, vocational counseling, suggestions for minimizing friction with family members, and, above all, hope that the life of the patient may be improved. Depending upon the severity of the symptoms, supportive therapy may begin with a healthcare professional helping the individual to recall the events and emotions that occurred before the acute episode, so that he or she may be able to watch for and recognize approaching signs of trouble. In all situations, supportive therapy involves the teaching of such life skills as managing medication, learning to socialize, handling finances, and getting a job. Ideally, in-patient programs should be linked as much as possible with appropriate community-based programs, to provide a continuing pattern of care. (From Health Canada)
C21110	Sympathetic_Block	Neural_Block	Sympathetic Block|Sympathetic Neural Block|Sympathetic Neural Blockade	Neural blockade of the sympathetic nerve roots.
C21111	Inflammation_Process	Host_Defense_Mechanism	Inflammation Process|Inflammation Process, Multicellular	Any cell or physiological process concerned with the complex series of local events that involve increased infiltration and activity of leukocytes and an increased blood supply to a site of injury or disease. (NCI)
C21112	KITLG_Gene	Cytokine_Gene	KITLG Gene|KIT Ligand Gene|KITLG|KL-1|Kitl|MGF|SCF|SF	The KITLG Gene encodes Kit Ligand, which is the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This gene produces two alternate transcripts: isoform a (lacking exon 6) encodes membrane-bound KITLG; isoform b encodes a protein that includes exon 6, which contains a cleavage site rendering the protein susceptible to post-translational proteolysis yielding soluble KITLG. Soluble KITLG is predominantly found as a non-covalent homodimer. KITLG is a pleiotropic factor that acts in uterus in germ cell and neural cell development, and hematopoiesis, all believed to reflect an KITLG role in cell migration. In adults, KITLG also functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. (from LocusLink)
C21113	TNFSF15_Gene	Tumor_Necrosis_Factor_Family_Gene	TNFSF15 Gene|TL1|TNFSF15|Tumor Necrosis Factor Ligand Superfamily Member 15 Gene|VEGI|Vascular Endothelial Growth Inhibitor Gene	Specifically expressed in endothelial cells (induced by TNF and IL-1 alpha), human TNFSF15 Gene (TNF Family) encodes 174-aa 20-kDa homotrimeric type II membrane protein autocrine cytokine Tumor Necrosis Factor Ligand Superfamily Member 15, a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6 with an extracellular C-terminus, a single transmembrane domain, and a short cytoplasmic tail. TNFSF15 inhibits endothelial cell proliferation and angiogenesis, and induces endothelial cell apoptosis by activation of p38 MAPK and caspase-3. (NCI)
C21114	Tumor_Necrosis_Factor_Family_Gene	Cytokine_Gene	Tumor Necrosis Factor Family Gene|TNF Family Gene	Tumor Necrosis Factor Family Genes encode Tumor Necrosis Factor Family Protein, structurally related cell surface proteins involved in lymphocyte homeostasis by induction of apoptosis.
C21115	Terminal_Sedation	Palliative_Care	Terminal Sedation|Assisted Suicide|Euthanasia|Mercy Killing	The purposeful use of morphine, other opiates, or other pharmaceuticals at doses adequate to end life functions.
C21116	Terminal_Illness	Retired_Concepts	Terminal Illness	An illness that has a prognosis of death.
C21117	Therapeutic_Heat	Pain_Therapy	Therapeutic Heat|Heat Therapy	The application of heat to appropriate painful areas to improve blood flow and function and to reduce pain.  It can be applied though many methods, using convection, conduction, or radiation.  Conduction uses hydrocollator, paraffin, or other similar methods.  Convection uses immersion hydrotherapy, immersion, forced fluidotherapy, and radiant heat.  Radiation uses laser.
C21118	Therapeutic_Cold	Pain_Therapy	Therapeutic Cold|Cold Therapy	The application of cold to appropriate painful areas to reduce inflammation immediately after an injury.
C21119	Traction	Treatment	Traction	The application of pulling forces to improve functional alignment.
C21120	Visual_Analog_Scale	Pain_Assessment_Tool	Visual Analog Scale|VAS|Visual Analogue Scale	A pain scale marked off like a ruler from 0 to 10 on which the patient marks the current level of pain experienced.
C21121	TNFRSF5_Gene	TNF_Receptor_Family_Gene	CD40 Gene|Bp50|CD40|CD40 Antigen (TNF Receptor Superfamily Member 5) Gene|CDW40|MGC9013|TNFRSF5|TNFRSF5 Gene|Tumor Necrosis Factor Receptor Superfamily Member 5 Gene|p50	Expressed in B-cells, human TNFRSF5 Gene (TNFR Family) encodes type I membrane protein isoform I (277-aa) or secreted isoform II (203-aa) of Tumor Necrosis Factor Receptor Superfamily Member 5, containing 4 TNFR-Cys repeats. Adaptor protein TNFR2 interacts with TNFRSF5 and mediates signal transduction. Essential in various immune and inflammatory responses as a receptor for TNFSF5/CD40L, TNFRSF5 interacts with TRAF1, TRAF2, TRAF3, TRAF5, and TRAF6. TNFRSF5 participates in T cell-dependent Ig class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA coordinately regulates expression of TNFSF5 and TNFRSF5. (NCI)
C21122	WHO_Analgesic_Method	Pain_Management_Method	WHO Analgesic Method|Three-Step Analgesic Ladder	Developed to promote the sequential use of drugs to achieve effective pain relief.  The first step is a non-opioid medication (such as aspirin, paracetamol, or ibuprofen).  If this does not relieve the pain, an opioid for mild to moderate pain (such as codeine) should be added.  When an opioid for mild to moderate pain in combination with a non-opioid medication does not provide effective analgesia, then an opioid for moderate to severe pain (such as morphine or one in the therapeutic group of morphine) should be substituted.  Adjuvant drugs should be given at any point during drug treatment to relieve adverse effects of analgesics, to enhance pain relief, and to treat concomitant psychological disturbances such as insomnia, anxiety, and depression. (WHO)
C21123	Pain_Management_Method	Treatment	Pain Management Method
C21124	Multicellular_Process	Biological_Process	Multicellular Process	A biologic function or process involving coordinated groups or populations of single cell types, mixed cell types, or tissues. (NCI)
C21125	Rolfing	Massage	Rolfing	A therapy designed to realign the body with gravity through fascial manipulation. (Taber's)
C21126	Ceiling_Effect	Conceptual_Entities	Ceiling Effect	The upper limit of efficacy where diminishing returns result from increasing dosages.
C21127	Single_Convention_on_Narcotic_Drugs	Guidelines	Single Convention on Narcotic Drugs	The principal international treaty regulating availability of opioids. It classifies the opioids, and requires the registration of all handlers and the estimation of medical needs for opioids. It establishes rules concerning production, manufacture and distribution, and requires statistical reports. The Single Convention governs how opioids are shipped between countries, using a system of import and export approval. The treaty also defines to some extent the requirements for safe distribution within a country.
C21128	Histogenesis	Developmental_Process	Histogenesis|Developmental Process, Multicellular|Tissue Development Process	A multicellular process involved in the formation of new, more mature, or differentiated cells or tissues. (NCI)
C21129	Physical_Dependence	Conceptual_Entities	Physical Dependence	The neuroadaptation of the body to the presence of an opioid, and is characterized by the onset of acute symptoms and signs of withdrawal if the opioid is stopped or an opioid antagonist is administered.
C21130	Tolerance	Biological_Effect_of_Chemicals	Drug Tolerance|Tolerance|drug tolerance	A condition that occurs when the body gets used to a medicine so that either more medicine is needed or different medicine is needed.
C21131	Psychological_Dependence	Conceptual_Entities	Psychological Dependence	A behavioral pattern characterized by a craving for the mood-altering effects of a drug and an overwhelming preoccupation with obtaining and using the drug.
C21132	TNFSF5_Gene	Tumor_Necrosis_Factor_Family_Gene	CD40LG Gene|CD154|CD40 Ligand (TNF Superfamily, Member 5, Hyper-IgM Syndrome) Gene|CD40L|CD40LG|TNFSF5|TRAP Gene	Specifically expressed on CD4+ and CD8+ T-lymphocytes (upregulated by IgE-inducer IL4 and suppressed by IgE-inhibitor gamma-interferon), human TNFSF5 Gene (TNF Family) encodes 261-aa 29-kDa (precursor) homotrimeric type II membrane glycoprotein Tumor Necrosis Factor Ligand Superfamily Member 5. As ligand for CD40 glycoprotein on B cells, TNFSF5 regulates B-cell proliferation, adhesion, Ig class switching, IL4-induced IgE production, and differentiation. A soluble form of TNFSF5 is derived by proteolytic processing of the membrane form. TNFSF5 Defects cause X-linked immunodeficiency. (NCI)
C21133	Verbal_Rating_Scale	Pain_Assessment_Tool	Verbal Rating Scale|VRS	A pain rating scale that includes specific pain criteria and self-reported ratings based upon patient verbalizations.
C21134	Wisconsin_Brief_Pain_Questionnaire	Pain_Assessment_Tool	Wisconsin Brief Pain Questionnaire	A self-administered questionnaire which measures pain at its worst, its least, average, and right now. Additionally, it uses a check list of adjectives to characterize the pain and information is collected on the impact of treatment and the impact of pain on function. (Dout, 1983)
C21135	McGill_Pain_Questionnaire	Pain_Assessment_Tool	McGill Pain Questionnaire	A questionnaire incorporating a series of adjectives to describe the characteristics and intensity of pain. The longer version of this instrument was used by Kane and colleagues to evaluate a clinical trial of hospice care. (Wales 1983)
C21136	Short-Form_McGill_Pain_Questionnaire	Pain_Assessment_Tool	Short-Form McGill Pain Questionnaire	A questionnaire incorporating a series of adjectives to describe the characteristics and intensity of pain. The longer version of this instrument was used by Kane and colleagues to evaluate a clinical trial of hospice care (Wales 1983)
C21137	Memorial_Pain_Questionnaire	Pain_Assessment_Tool	Memorial Pain Questionnaire	A two-sided card that measures pain intensity and the patient's mood on one side, and has a modified version of the Tursky Pain Description Scale on the other. (Fishman 1987)
C21138	Patient_Outcome_Questionnaire	Pain_Assessment_Tool	Patient Outcome Questionnaire	Questionnaire designed as part of the APS's guidelines for pain treatment. The instrument measures pain severity, interference, satisfaction with pain control, and various aspects of pain treatment and medication. (APS 1995)
C21139	Descriptor_Differential_Scale	Pain_Assessment_Tool	Descriptor Differential Scale	Measures the sensory and affective components of pain using a magnitude ratio scale. (Gracey 1988)
C21140	Metastasis_Suppressor_Protein	Protein_Organized_by_Function	Metastasis Suppressor Protein	Proteins involved in the inhibition of tumor cell metastasis.
C21141	KiSS1_Metastasis_Suppressor_Protein	Protein_with_Unknown_or_Unclassified_Function	KiSS1 Metastasis Suppressor Protein|KISS1|KISS1 Metastasis Suppressor|Malignant Melanoma Metastasis-Suppressor|Malignant Melanoma Metastasis-Suppressor KiSS-1	Encoded by human KISS1 Gene, the 145-amino acid 15 kD KISS1 Metastasis Suppressor Protein may regulate events downstream of cell-matrix adhesion, perhaps cytoskeletal reorganization. Expressed in placenta, pancreas, and kidney, KISS1 may suppress metastasis without affecting tumorigenicity. Metastin, a placental truncated C-terminally amidated peptide form of KISS1, with 54 amino acid residues, is an endogenous ligand of orphan GPR54 (GPCR) and appears to inhibit chemotaxis and metastasis. (NCI)
C21142	Integrated_Pain_Scale	Pain_Assessment_Tool	Integrated Pain Scale|Integrated Pain Score	An instrument designed to take into account both pain intensity and duration. (Ventafridda 1983)
C21143	Myelopoiesis	Hematopoiesis	Myelopoiesis	The formation of non-leukoid differentiated blood cells (NCI)
C21144	TNFSF10_Gene	Tumor_Necrosis_Factor_Family_Gene	TNFSF10 Gene|APO2L|Apo-2L|TL2|TNFSF10|TRAIL|Tumor Necrosis Factor (Ligand) Superfamily, Member 10 Gene	TNFSF10 Gene at 3q26 encodes Tumor Necrosis Factor Ligand Superfamily Member 10, which is a homotrimeric type II membrane protein that rapidly induces oligomerization of receptor intracellular death domains and apoptosis in a variety of cells. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. (From LocusLink, OMIM and NCI)
C21145	ADAM_Family_Protein	Transmembrane_Protein	ADAM Family Protein	The ADAM family consists of transmembrane proteins that contain a disintegrin and metalloprotease domain.  By virtue of these domains they have the potent for both cell adhesion and protease activities. Currently, the ADAM family has 29 membranes, although the function of most ADAM gene products is unknown. The ADAM gene products with known functions act in a highly diverse set of biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-alpha release and the inflammatory response. (NCI)
C21147	Developmental_Process	Multicellular_Process	Developmental Process	A process that promotes the formation of new, more mature, or differentiated tissues, organs, or organ systems. May be, and often is, part of general development, but is not restricted to occur only during general development. (NCI)
C21148	TNFSF6_Gene	Tumor_Necrosis_Factor_Family_Gene	FASLG Gene|APT1LG1|CD178|CD95L|FASL|Fas Ligand (TNF Superfamily, Member 6) Gene|Fas Ligand Gene|TNFSF6	Expressed in many cell types, human TNFSF6 Gene (TNF Family) encodes 281-aa 31-kDa (precursor) N-glycosylated homotrimeric type II membrane protein cytokine Tumor Necrosis Factor Ligand Superfamily Member 6, FAS ligand. Interaction with cell surface apoptotic receptor TNFRSF6/FAS triggers apoptosis in lymphocytes, while decoy receptor TNFRSF6B/DcR3 binding modulates its effects. Secreted from T-cells upon TCR ligation by MHC/peptide complexes on APCs, the soluble form derives from the membrane form by proteolytic processing. TNFRSF6/FAS-mediated apoptosis may induce peripheral tolerance or antigen-stimulated T-cell suicide. TNFSF6 defects cause ALPS. (NCI)
C21149	TNFSF4_Gene	Tumor_Necrosis_Factor_Family_Gene	TNFSF4 Gene|CD134L|GP34|OX40L|TNFSF4|TXGP1|Tumor Necrosis Factor (Ligand) Superfamily, Member 4 (Tax-Transcriptionally Activated Glycoprotein 1, 34kDa) Gene|Tumor Necrosis Factor (Ligand) Superfamily, Member 4 Gene	Human TNFSF4 Gene (TNF Family) encodes 183-aa 21-kDa homotrimeric type II membrane protein cytokine Tumor Necrosis Factor Ligand Superfamily Member 4, a ligand for receptor TNFRSF4/OX40. In stimulated B cells, along with CD70, this cytokine provides CD28-independent costimulatory signals to T cell proliferation and cytokine production. Involved in T-cell/APC interactions, TNFSF4 also mediates adhesion of activated T cells to vascular endothelia. (NCI)
C21150	Pain_Perception_Profile	Pain_Assessment_Tool	Pain Perception Profile	An instrument measuring the affective, sensory and intensity dimensions of pain. (Tursky 1976)
C21151	West_Haven-Yale_Multidimensional_Pain_Inventory	Pain_Assessment_Tool	West Haven-Yale Multidimensional Pain Inventory	A 52 item chronic pain inventory. (Kerns 1985)
C21152	Unmet_Analgesic_Needs_Questionnaire	Pain_Assessment_Tool	Unmet Analgesic Needs Questionnaire	A tool designed for cancer patients to measure prevalence and intensity of pain, and identify characteristics associated with unmet analgesic needs and dissatisfaction with pain control. (Zhukovsky 1994)
C21153	City_of_Hope_Mayday_Pain_Resource_Center_Patient_Pain_Questionnaire	Pain_Assessment_Tool	City of Hope Mayday Pain Resource Center Patient Pain Questionnaire	A 16 item ordinal scale that measures a patient's knowledge and experience in managing chronic cancer pain. There is also a Family Pain Questionnaire that measures the family caretaker's knowledge and experience.
C21154	Symptom_Specific_Assessment_Tool	Clinical_Assessment_Tool	Symptom Specific Assessment Tool	Any one of several evaluation/assessment tools used to ascertain a patient's complaints with regard to his or her specific condition or diagnosis.
C21155	Baseline_Dyspnea_Index	Symptom_Specific_Assessment_Tool	Baseline Dyspnea Index	A clinically derived index of the severity of patient dyspnea based on functional impairment, magnitude of tasks that result in dyspnea, and the degree of effort that produces dyspnea. (Mahler 1988)
C21156	Quality_of_Life_in_Chronic_Lung_Disease	Clinical_Assessment_Tool	Quality of Life in Chronic Lung Disease|QOL in Chronic Lung Disease	A multidimensional index to assess outcomes of clinical trials in patients with COPD. (Guuyatt 1987)
C21157	Medical_Research_Council_Dyspnea_Scale	Symptom_Specific_Assessment_Tool	Medical Research Council Dyspnea Scale	A scale grading dyspnea from 0 (not troubled with breathlessness except with strenuous exercise) to 4 (too breathless to leave the house or breathless when dressing or undressing). (Brooks 1982)
C21158	ATS-DLD-78_Adult_Questionnaire	Symptom_Specific_Assessment_Tool	ATS-DLD-78 Adult Questionnaire	A questionnaire designed by the American Thoracic Society that assesses cough, phlegm, wheezing, breathlessness, illness and risk factors. (Brooks 1982)
C21159	Peptidase_Family-M12B	Protein_Family	Peptidase Family M12B	The Peptidase Family-M12B (Reprolysin Family, Adamalysins) consists of evolutionarily-related zinc metalloproteases of structural and functional similarity based on sequence conservation or residue identity. Some family members may not be active enzymes.
C21160	Immunoglobulin_Binding_Protein	Ligand_Binding_Protein	Immunoglobulin Binding Protein|Immunoglobulin Binding Factor	Immunoglobulin Binding Proteins temporarily and non-covalently interact through physical forces of attraction and spatial complementarity with structurally-related Y-shaped monomeric or polymeric glycoproteins produced by B-lymphocytes that function as antibodies.
C21161	Beta-Microseminoprotein	Immunoglobulin_Binding_Protein	Beta-Microseminoprotein|Immunoglobulin Binding Factor|MSMB|Prostate Secreted Seminal Plasma Protein|Prostate Secretory Protein|Prostatic Secretory Protein 94|Seminal Plasma Beta-Inhibin	Encoded by human MSMB Gene (Ig Binding Factor Family, Beta-Microseminoprotein Family), 12.8 kD (precursor) secreted Beta-Microseminoprotein (isoforms PSP94 and PSP57) is expressed in prostate, liver, kidney, breast, penis, pancreas, esophagus, stomach, duodenum, colon, trachea, lung, salivary glands, and fallopian tube. PSP94 is also expressed in lung and breast; PSP57 is found in kidney and bladder. The 94-amino acid seminal protein is derived from a pre-polypeptide of 114 amino acids. Specific receptors are found on spermatozoa and in the prostate. The protein may have inhibin-like activity; it may act as an autocrine paracrine factor in uterine, breast, and other female reproductive tissues and may inhibit pituitary secretion of FSH. (from Swiss-Prot, OMIM, and NCI)
C21162	ITGAM_Gene	Cell_Adhesion_Molecule_Gene	ITGAM Gene|CD11B|CR3A|ITGAM|Integrin, Alpha M (Complement Component Receptor 3, Alpha; Also Known As CD11b (p170), Macrophage Antigen Alpha Polypeptide) Gene|MAC-1|MAC1A|MO1A	Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGAM encodes the integrin alpha M chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles (from LocusLink)
C21163	TNF_Receptor-Associated_Factor-4_Protein	Signaling_Protein	TNF Receptor-Associated Factor 4 Protein|Cysteine-Rich Domain Associated With Ring and TRAF Domains|MLN62 Protein|Malignant 62|TRAF4|TRAF4 Protein|Tumor Necrosis Receptor-Associated Factor 4A	Encoded by human TRAF4 Gene, 198-amino acid 22.8 kD TNF Receptor-Associated Factor 4 Protein has an unusual N-terminal RING-type zinc finger motif, a more central cysteine-rich domain containing a CART motif, and a C terminal TRAF domain.  TRAF4 is a member of the TRAF family of proteins that interact with TNF receptors and appears to be involved in TNF-related cytokine signal transduction.  (from SWISS-PROT, OMIM, and NCI)
C21164	Beta-Microseminoprotein_Family	Retired_Concepts	Beta-Microseminoprotein Family
C21165	TNF_Receptor_Family_Gene	Cytokine_Receptor_Gene	TNF Receptor Family Gene	Human TNF Receptor Family Genes encode transmembrane receptor proteins regulated by TNF Family ligands. TNF receptors typically contain intracellular death domains involved in the formation of a signal transducing death-inducing complex that includes FADD and caspases that trigger an apoptotic caspase cascade. Some TNF receptors can activate NF-Kappa-B, MAPK3/ERK1, MAPK8/JNK, BIRC1, BIRC2, BAG4/SODD, TRADD, or TRAF2 and transduce inflammation or anti-apoptotic proliferating signals. Some TNF Family Receptors act as competitive decoy receptors in bone resorption or suppress FasL- and LIGHT-mediated cell death. (NCI)
C21166	CD72_Gene	Cell_Adhesion_Molecule_Gene	CD72 Gene|CD72|CD72 Antigen Gene|LYB2	The CD72 gene encodes CD72 Antigen, whose expression is restricted to B-lineage cells and is turned off in differentiated antibody-secreting plasma cells. CD72 Antigen may participate in signals for B-cell proliferation and differentiation. In the immune system, CD72 appears to be a receptor for leukocyte activation antigen, CD100. CD72 may also be the ligand for CD5, a receptor that regulates T-cell proliferation. (from OMIM 107272, SWISS-PROT P21854, and NCI)
C21167	CHGA_Gene	Chromogranin_Gene	CHGA Gene|CGA|CHGA|Chromogranin A (Parathyroid Secretory Protein 1) Gene|Chromogranin A Gene	The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Other peptides, including chromostatin, beta-granin, WE-14 and GE-25, are also derived from the full-length protein. However, biological activities for these molecules have not been shown. (LocusLink)
C21168	Immune_Function_System	Retired_Concepts	Immune Function, System
C21169	SHBG_Gene	Ligand_Binding_Protein_Gene	SHBG Gene|ABP|SBP|SHBG|Sex Hormone-Binding Globulin Gene	Expressed in Sertoli cells and liver, 8-exon human SHBG Gene at 17p13-p12 encodes 2 alternative isoforms of 402-aa 44-kDa (precursor) homodimeric secreted glycoprotein Sex Hormone-Binding Globulin, a plasma beta-globulin containing 2 laminin G-like domains that specifically binds one molecule of 5-alpha-dihydrotestosterone, testosterone, or 17-beta-estradiol. An androgen transport protein, SHBG regulates the plasma metabolic clearance rate of steroid hormones by controlling plasma concentration and may be involved in receptor-mediated processes as well. (NCI)
C21170	DNA_Repair_Protein	Protein_Organized_by_Function	DNA Repair Protein	Any of the proteins involved in the enzymatic restoration of DNA structure after chemical, radiation, or spontaneous damage.
C21171	Nibrin	DNA_Repair_Protein	Nibrin|AT-V1|AT-V2|ATV|Cell Cycle Regulatory Protein P95|MRE11/RAD50 Complex p95 Protein|NBS|NBS1|Nijmegen Breakage Syndrome Protein 1	Encoded by human NBS1 Gene, ubiquitous expression of 754-amino acid 85 kD Nibrin occurs principally in testis, thymus, and spleen (sites of physiologic DNA double-strand breakage) and liver, lung, striated/smooth muscle, kidney, and gut (high proliferative activity). Nibrin contains a forkhead-associated domain and a C-terminal breast cancer domain. As part of the p95/NBS1/p200/p400/MRE11/RAD50 and the BASC complexes, NBS1 participates in DNA repair and meiotic recombination. Serine phosphorylation by ATM is linked to S-phase checkpoint activation. Nibrin/gamma-H2AX associate with V(D)J recombination sites in response to RAG1-mediated cleavage. Ig Class switch DNA recombination recruits NBS1/gamma-H2AX in G1. NBS1 mutations are associated with Nijmegen breakage syndrome, chromosomal instability, cancer, and cell cycle checkpoint defects. (from Swiss-Prot, OMIM, and NCI)
C21172	Aging-Related_Process	Organismal_Process	Aging-Related Process|Aging Process	Any physiological aspect of aging; irreversible changes in an organism that occur over time and lead to a more mature condition. (NCI)
C21173	Reproductive_Process	Reproductive_System_Process	Reproductive Process	Any general physiological process of tissues, organs, or organ systems related to reproduction. (NCI)
C21174	CAV1_Gene	Signaling_Pathway_Gene	CAV1 Gene|CAV Gene|CAV1|Caveolae Protein, 22-kD Gene|Caveolin 1 Gene|Caveolin 1, Alpha Isoform Gene|Caveolin 1, Beta Isoform Gene|Caveolin 1, Caveolae Protein, 22kDa Gene|Caveolin-1 Gene|VIP21 Gene	The CAV1 gene at 7q31.1 encodes Caveolin 1 (CAV1), a scaffolding protein and the main component of the caveolae plasma membranes found in most cell types. CAV1 and CAV2 form Caveolin, a stable hetero-oligomeric complex important in the formation and maintenance of caveolae. In the absence of caveolin no morphologically identifiable caveolae exist, with one exception where in neuronal cells CAV 1 and CAV 2 are expressed but there are no morphologically recognizable caveolae. Caveolin 1 links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. Caveolin expression is correlated both to oncogenic transformation and its reversal. CAV1 is a tumor suppressor candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. Alternative splicing results in 2 isoform proteins (alpha, beta). (NCI)
C21175	Growth_Arrest_Specific_Protein	Retired_Concepts	Growth Arrest Specific Protein
C21176	Protein_or_Riboprotein_Complex	Gene_Product	Protein or Riboprotein Complex	Multimeric subcellular structures containing proteins, and possibly, RNA.
C21177	MRE11-RAD50_Double-Strand_Break_Repair_Complex	Repair_Complex	MRE11/RAD50 Double-Strand Break Repair Complex	The MRE11/RAD50 double-strand break repair complex consists of 5 proteins: Nibrin, p200, p400, MRE11, and RAD50. This complex possesses manganese-dependent single-stranded DNA endonuclease and 3-prime to 5-prime exonuclease activities. In mammalian cells, this complex is important for double-strand break repair, meiotic recombination, and telomere maintenance. It functions in diverse aspects of the cellular response to double strand breaks (DSBs), including the detection of DNA damage, the activation of cell cycle checkpoints, and DSB repair. (from OMIM)
C21178	NBS1_Gene	DNA_Repair_Gene	NBN Gene|AT-V1 Gene|AT-V2 Gene|ATV Gene|NALP2|NBS Gene|NBS1|NBS1 Gene|Nibrin Gene|Nijmegen Breakage Syndrome 1 (Nibrin) Gene|Nijmegen Breakage Syndrome 1 Gene|PYPAF2	Human NBS1 Gene at 8q21 contains sixteen exons over 50 kb that encode 754-amino acid Nibrin, likely involved in DNA double-strand break (DSB) repair, checkpoint activation, and apoptosis. C8ORF1 (5-prime), NBS1 (3-prime), DECR1 (5-prime), and CALB1 (3-prime) occur in an 800 kb region. Highly expressed in testis and organs with physiologic DNA DSB or high proliferative activity; 2.4- and 4.4 kb NBS1 transcripts occur widely. Nibrin contains a forkhead-associated domain and a C-terminal breast cancer domain, a Dapin domain, a Nacht domain, and nine Leucine-Rich Repeats. Nibrin is part of the MRE11/RAD50 DSB repair/recombination complex and part of BASC, which may regulate postreplication repair. ATM phosphorylation of Nibrin is linked to S-phase checkpoint activation. NBS1 mutations are associated with Nijmegen breakage syndrome. (from Swiss-Prot Q9NX02, OMIM 602667, and NCI)
C21179	CLIC4_Gene	Ion_Channel_Protein_Gene	CLIC4 Gene|CLIC4|CLIC4L|Chloride Intracellular Channel 4 Gene|DKFZP566G223|H1|P64H1|huH1	Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, trans-epithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the CLIC4 gene, is a member of the p64 family; the gene is expressed in many tissues and exhibits an intracellular vesicular pattern in Panc-1 cells (pancreatic cancer cells). (LocusLink)
C21180	Chloride_Intracellular_Channel-4	Ion_Channel_Protein	Chloride Intracellular Channel 4|CLIC4	A p53- and tumor necrosis factor alpha-regulated cytoplasmic and mitochondrial protein that belongs to the CLIC family of intracellular chloride channels. mtCLIC associates with the inner mitochondrial membrane. Dual regulation of mtCLIC by two stress response pathways suggested that this chloride channel protein might contribute to the cellular response to cytotoxic stimuli. DNA damage or overexpression of p53 upregulates mtCLIC and induces apoptosis. Overexpression of mtCLIC by transient transfection reduces mitochondrial membrane potential, releases cytochrome c into the cytoplasm, activates caspases, and induces apoptosis. mtCLIC is additive with Bax in inducing apoptosis without a physical association of the two proteins. Antisense mtCLIC prevents the increase in mtCLIC levels and reduces apoptosis induced by p53 but not apoptosis induced by Bax. (From Mol Cell Biol 2002;22:3610-20)
C21181	NOVA_Family	Protein_Family	NOVA Family	Expressed in brain (neurons or astrocytes), NOVA Family Genes encode NOVA Family nuclear proteins (NOVA1, NOVA2), autoantigens in POMA recognized by IgG ANNA-2 that contain 3 KH domains and may regulate RNA splicing in neurons and astrocytes. NOVA proteins form structural complexes with other proteins. Found as one or multiple copies of a conserved 70-aa motif in diverse nucleic acid binding, and other, proteins, the KH domain binds RNA; each motif appears necessary for binding. (NCI)
C21182	Neuro-Oncological_Ventral_Antigen-1	RNA_Binding_Protein	Neuro-Oncological Ventral Antigen 1|NOVA-1|NOVA1|Onconeural Ventral Antigen-1|Paraneoplastic Ri Antigen|Ri Antigen|Ventral Neuron-Specific Protein 1	Encoded by human NOVA1 Gene (Nova Family), the 510-amino acid 52 kD NOVA-1 Protein is a brain neuron-specific nuclear RNA-binding protein. NOVA-1 contains three KH domains and may regulate RNA splicing or metabolism in specific developing neurons. It binds RNA in a sequence-specific manner to regulate neuron-specific splicing of inhibitory receptor pre-mRNAs in postnatal motor neurons. Murine Nova1 specifically binds to the GLRA2 intronic (UCAUY)3 sequence motif. (from Swiss-Prot, OMIM, and NCI)
C21183	Nucleoporin	Structural_Protein	Nucleoporin|Nuclear Pore Complex Protein|Nup Protein	Signal-mediated nuclear import and export proceed through the nuclear pore complex (NPC), which is comprised of approximately 50 unique proteins collectively known as nucleoporins. The proteins encoded by these genes function in the nuclear transport of protein and RNA. (from LocusLink 4928, OMIM 601021)
C21184	Nucleoporin-98kD	Nucleoporin	Nucleoporin 98kD|98 kD Nucleoporin|ADIR2|GLFG-Repeat Containing Nucleoporin|NUP196|NUP98|NUP98-NUP96 Precursor|Nuclear Pore Complex Protein NUP98|Nucleoporin NUP98	Encoded by human NUP98 Gene (GLFG Nucleoporin Family), 937-amino acid Nucleoporin 98 kD (NUP98) is up regulated by interferon and generated through proteolytic cleavage of a 186 kD precursor yielding NUP98 and NUP96, both associated with the nuclear pore complex (NPC). NPC targeting of NUP96 and NUP98 is cleavage dependent, which may regulate assembly of the NPC, comprised of nearly fifty nucleoporins involved in signal-mediated nuclear import and export of protein and RNA. NUP98 likely functions as an import docking protein. The NUP98 C-terminal RNA-binding domain also contains NPC target sequences, a novel protein fold, and an autocatalytic protease. NUP98 docking/transport function is localized to N-terminal GLFG/FXFG repeats. mRNA nuclear export inhibition by Vesicular Stomatitis Virus M Protein targets NUP98. (from Swiss-Prot, OMIM, and NCI)
C21185	NPM1_Gene	Structural_Gene	NPM1 Gene|B23|NPM|NPM1|NUMATRIN|Nucleophosmin (Nucleolar Phosphoprotein B23, Numatrin) Gene	Nucleophosmin is a nucleolar phosphoprotein that is more abundant in tumor cells than in normal resting cells. Stimulation of the growth of normal cells, e.g., mitogen activation of B lymphocytes, is accompanied by an increase in nucleophosmin protein level. Although the function of nucleophosmin has not been defined precisely, ample evidence suggests that it is involved in the assembly of ribosomal proteins into ribosomes. Electron microscopic study indicates that nucleophosmin is concentrated in the granular region of the nucleolus, where ribosome assembly occurs. (from OMIM)
C21186	Tumor_Expansion	Tumor_Progression	Tumor Expansion	Growth of a tumor involving either an increase in size of a continuous tumor tissue mass or translocation of tumor cells to secondary sites. (NCI)
C21187	TSSC5_Protein	Transport_Protein	Tumor Suppressing Subtransferable Candidate 5 Protein|Beckwith-Wiedemann Syndrome Chromosome Region 1, Candidate A|Efflux Transporter-Like Protein|Imprinted Multi-Membrane Spanning Polyspecific Transporter-Related Protein|Imprinted Polyspecific Membrane Transporter 1|Organic Cation Transporter-Like 2|Organic Cation Transporter-Like 2 Protein|SLC22A1L|Solute Carrier Family 22, Organic Cation Transporter, Member 1-Like|TSSC5|Tumor-Suppressing STF 5|Tumor-Suppressing STF cDNA 5|p45-BWR1A	Expressed predominantly in fetal and adult liver and kidney by human SLC22A1L Gene (Polyspecific Transporter/MDR Family), 424-aa Tumor Suppressing Subtransferable Candidate 5 Protein (Organic Cation Transporter-Like 2 Protein) is a polyspecific organic-cation transporter, containing 10 transmembrane segments, involved in excretion of endogenous and exogenous compounds. SLC22A1L translation may begin at the second methionine, which would result in a 408-amino acid protein. (NCI)
C21188	Tumor-Associated_Process	Pathologic_Process	Tumor-Associated Process|Tumor Process	An event, process, or condition that supports, or results from, tumor development. (NCI)
C21189	Metabolic_Process_Organismal	Retired_Concepts	Metabolic Process, Organismal	A general physiologic process, usually associated with a specific organ or organ system, typically related to homeostasis and/or energy production. (NCI)
C21190	Physiologic_Reproductive_Process	Retired_Concepts	Physiologic Reproductive Process
C21191	BCL2-Binding_Protein	Apoptosis_Promoter	BCL2-Binding Protein|BAD|BAD Protein|BCL-X/BCL-2 Binding Protein|BCL2-Antagonist of Cell Death|BCL2-Binding Component 6	This protein is a member of the BCL-2 family. It positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. (from RefSeq Summary)
C21192	BCL2-Antagonist_Killer-1	Apoptosis_Promoter	BCL2-Antagonist/Killer 1|Apoptosis Regulator BAK|BAK1|Bcl-2 Homologous Antagonist/Killer|Cell Death Inhibitor 1	A BCL2 related protein that induces apoptosis.  May cause the mitochondrial voltage-dependent anion channel to open and release cytochrome c into the cytoplasm resulting in caspase activation. (from RefSeq Summary)
C21193	BCL2-Related_Protein_1_Long_Isoform	Retired_Concepts	BCL2-Related Protein 1, Long Isoform|BCL2-Like 1, Long Isoform
C21194	BCL2-Related_Protein_1_Short_Isoform	Retired_Concepts	BCL2-Related Protein 1, Short Isoform|BCL2-Like 1, Short Isoform
C21195	BCL2-Related_Protein-11	Apoptosis_Promoter	BCL2-Related Protein 11|BAM|BCL2L11|BIM|BIMEL|BIML|BOD|Bcl-2 Interacting Protein Bim|BimMEL	This protein belongs to the BCL-2 protein family. It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests the roles of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this protein functions as an essential initiator of the apoptosis in thymocyte-negative selection. (from RefSeq Summary)
C21196	Immune_Function_Subcellular	Retired_Concepts	Immune Function, Subcellular	Any subcellular or molecular event, process, or condition involved in supporting or regulating the immune response or immune maintenance. (NCI)
C21197	BCL2-Related-2_Protein	Apoptosis_Inhibitor	BCL2-Related 2 Protein|Apoptosis Regulator BCL-W|BCL-W|BCL2 Like 2|BCL2-Like 2|BCL2L2|BCL2L2 Protein|BCLW|KIAA0271	This protein is a member of the BCL-2 protein family. Expression of this protein in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. (from RefSeq Summary)
C21198	Intermediary_Metabolism	Metabolic_Process	Intermediary Metabolism|METBL|Metabolism|metabolism	Intermediary Metabolism consists of all the reactions in an organism concerned with storing and generating metabolic energy and with the biosynthesis of low-molecular weight compounds, energy-storage compounds, and basic materials needed for important life processes. It does not include nucleic acid and protein synthesis. (NCI)
C21199	BH3_Interacting_Domain_Death_Agonist_Protein	Apoptosis_Promoter	BH3 Interacting Domain Death Agonist|BID|BID Protein	BID (BH3 Interacting domain Death agonist) is a death agonist that heterodimerizes with either agonists (BAX) or antagonists (BCL2). BID is a member of the BCL-2 family of cell death regulators. BID is a mediator of mitochondrial damage induced by caspase-8 (CASP8); CASP8 cleaves BID, and the COOH-terminal part translocates to mitochondria where it triggers cytochrome c release. (from RefSeq Summary)
C21200	Chromogranin_Gene	Peptide_Hormone_Gene	Chromogranin Gene	Chromogranin Genes encode Chromogranins, widespread heterogenous acidic soluble glycopropolypeptide constituents of neuroendocrine and chromaffin cell secretory granules that elicit an effect themselves or serve as precursors to many biologically active peptides. (NCI)
C21201	CHGB_Gene	Chromogranin_Gene	CHGB Gene|CGB Gene|CHGB|SCG1 Gene	Encodes Chromogranin B, a tyrosine-sulfated secretory protein found in a wide variety of peptidergic endocrine cells.  Chromogranin functions as a neuroendocrine secretory granule protein which may be the precursor for other biologically active peptides. (LocusLink)
C21202	Viral_Reverse_Transcription	Viral_Function	Viral Reverse Transcription|Reverse Transcription, Viral	The action of synthesizing a DNA product from a viral RNA template by a viral reverse transcriptase. (NCI)
C21203	BCL2-Interacting_Killer_Protein	Apoptosis_Promoter	BCL2-Interacting Killer|Apoptosis-Inducing NBK|BIK	This protein is known to interact with cellular and viral survival-promoting proteins, such as BCL2, BCLXL, Epstein-Barr virus BHRF1, and adenovirus E1B 19-kD in order to enhance programed cell death. Because its activity is suppressed in the presence of survival-promoting proteins, this protein is suggested as a likely target for antiapoptotic proteins. This protein shares a critical BH3 domain with other death-promoting proteins, BAX and BAK. (from RefSeq Summary and OMIM)
C21204	Organic_Cation_Transporter	Transport_Protein	Organic Cation Transporter	Organic Cation Transporter proteins carry positively charged chemical substances containing covalently bound carbon atoms through solubility barriers, such as lipid membranes or across epithelial layers. After binding substrate, transmembrane transporters often undergo an energy-dependent conformational change that moves the substrate across the membrane with (symport) or against (antiport) concentration gradients.
C21205	SCG2_Gene	Chromogranin_Gene	SCG2 Gene|CHGC|Chromogranin C Gene|SCG2|Secretogranin II (Chromogranin C) Gene|Secretogranin II Gene|SgII	The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown. (LocusLink)
C21206	Harakiri	Apoptosis_Promoter	Harakiri|Activator of Apoptosis HRK|HRK|HRK Protein	Hrk is a protein promoting cell death by apoptosis. Hrk physically interacts with the survival-promoting proteins bcl-2 and bcl-xL, which also block cell death induced by expression of Hrk. Hrk does not interact with death-promoting proteins Bax or Bak.
C21207	Prohibitin	Regulatory_Protein	Prohibitin|PHB	Encoded by human PHB Gene (Prohibitin Family), evolutionarily conserved ubiquitously expressed Prohibitin is a 272-amino acid 30 kD cytoplasmic antiproliferative protein that inhibits DNA synthesis, regulates proliferation, and may be a tumor suppressor. Prohibitin is expressed in proliferating cells. Mutations in PHB have been linked to sporadic breast cancer. (from Swiss-Prot, OMIM, and NCI)
C21208	BRCA1_Associated_RING_Domain_Protein_1	Retired_Concepts	BRCA1 Associated RING Domain Protein 1|BARD1 Protein|BRCA1 Associated RING Domain 1|BRCA1-Associated RING Domain 1	Encoded by human BARD1 Gene, nuclear BARD-1 Protein contains a RING zinc finger, three tandem ANK repeats, and two BRCT domains. BARD-1 heterodimerizes with BRCA1 via its N-terminal region and interacts with CSTF-50. BARD1/CSTF1 interacts with RNA Polymerase-2, which may inhibit pre-mRNA cleavage or polyadenylation. BARD-1/RNA Polymerase-2 holoenzyme may sense DNA damage; inhibition by CSTF1 may prevent erroneous polyadenylation of such RNAs. Processed during apoptosis, BARD-1 may mediate apoptosis; homodimers are more susceptible to proteolytic cleavage than BARD1/BRCA1. BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1; a stable BARD1/BRCA1 complex may be essential to BRCA1 tumor suppression. BARD-1 defects are found in primary breast, ovarian and uterine cancers. (from Swiss-Prot Q99728, OMIM 601593, and NCI)
C21209	RAD51_Homolog-C_Protein	DNA_Repair_Protein	RAD51 Homolog C|DNA Repair Protein RAD51 Homolog 3|RAD51C|RAD51L2	Encoded by human RAD51C Gene (RECA Family, RAD51 Subfamily), the 376-amino acid 42 kD RAD51 Homolog C is a probable nuclear protein likely involved in meiotic recombination and repair of damaged DNA. Highest expression is observed in testis, heart muscle, spleen, and prostate. RAD51 family members are strand-transfer proteins thought involved in recombinational repair of damaged DNA and in meiotic recombination. RAD51C protein interacts strongly with RAD51B and moderately with XRCC3 DNA repair proteins, but not with itself. The RAD51C/XRCC3 complex binds single-stranded, but not duplex, DNA. (from Swiss-Prot, OMIM, and NCI)
C21210	Ribosomal_Protein	Translation_Process_Protein	Ribosomal Protein	Proteins present within the ribosomal subunits. In eukaryotes there are 50 proteins in the large subunit and 33 in the small subunit. (from On-line Medical Dictionary)
C21211	Ribosomal_Protein-L13	Ribosomal_Protein	Ribosomal Protein L13|60S Ribosomal Protein L13|Breast Basic Conserved Protein 1|RPL13	Encoded by human RPL13 Gene (L13E Ribosomal Protein Family), highly conserved 210-amino acid 24 kD cytoplasmic Ribosomal Protein L13 is a ribosomal 60S subunit protein. The protein is highly basic with no signal or transmembrane sequence, but has two potential nuclear localization signals. Ribosomes consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately eighty structurally distinct proteins. (from Swiss-Prot, OMIM, and NCI)
C21212	Ribonucleotide_Reductase_Subunit	Protein_Complex_Subunit	Ribonucleotide Reductase Subunit	Encoded by Ribonucleotide Reductase Subunit Genes (RRM1 and RRM2), the M1 Chain and M2 Chain subunits compose Ribonucleoside-Diphosphate Reductase, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. A substrate site and catalytic site regulate enzyme activity. Allosteric control by deoxynucleoside triphosphates and by ATP bound to M1 prevents DNA replication and cell proliferation. An M1 catalytic site only forms in the presence of M2. M2 synthesis is cell-cycle dependent. p53 regulates ribonucleotide reductase by interaction with p53R2 as well as the M2 subunit. (NCI)
C21213	Ribonucleoside-Diphosphate_Reductase-M1_Chain	Ribonucleotide_Reductase_Subunit	Ribonucleoside-Diphosphate Reductase M1 Chain|RRM1|RRM1 Protein|Ribonucleotide Reductase Large Chain|Ribonucleotide Reductase M1 Polypeptide|Ribonucleotide Reductase R1 Subunit	Encoded by human RRM1 Gene, Ribonucleoside-Diphosphate Reductase M1 Chain is 1 of 2 ribonucleoside-diphosphate reductase subunits, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Complex allosteric control, mediated by deoxynucleoside triphosphates, and by ATP bound to the M1 subunit prevents DNA replication and cell proliferation. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. RRM1 functions as a metastasis suppressor gene through induction of PTEN expression and PTEN-regulated pathways. (from Swiss-Prot, OMIM, LocusLink and NCI)
C21214	Calcium_Binding_Protein	Ligand_Binding_Protein	Calcium Binding Protein	Calcium Binding Proteins typically belong to the same evolutionary family and often share an EF-hand calcium-binding domain that consists of a 12 residue loop flanked on both sides by a 12 residue alpha-helical domain; the calcium ion is coordinated with oxygen of Glu or Asp residues in a pentagonal bipyramidal configuration. Reversible binding of calcium with proteins often supports protein structure or induces an alteration of protein activity in enzymatic or cell signaling cascades. Calcium is essential for maintenance of a normal heartbeat and for normal cell functions. It also plays a role in blood coagulation and in many enzymatic processes.
C21215	S100_Calcium_Binding_Protein-A2	S100_Calcium_Binding_Protein	S100 Calcium Binding Protein A2|CAN19|S-100L Protein|S100 Calcium-Binding Protein A2|S100A2	Encoded by human S100A2 Gene, 97-amino acid 11 kD S-100L Protein is a member of the S100 Family of cell specific Ca2+-binding proteins containing EF-hand calcium-binding motifs. Induced by growth factors in early G1 and probably by cell-cycle regulation in S phase, S100A2 is preferentially expressed in mammary epithelia and in keratinocytes. S100 proteins are cytoplasmic or nuclear and involved in regulation of cell cycle progression and differentiation. Containing two EF-hand calcium-binding domains, S100 Calcium-Binding Protein A2 interacts with target proteins to link extracellular stimuli to cellular responses and may modulate excess calcium accumulation in mammary epithelial cells. Altered expression of S100A2 has been implicated in breast cancer. (from Swiss-Prot, OMIM, and NCI)
C21216	Calcium_Binding	Metal_Ion_Binding	Calcium Binding	Calcium Binding consists of a biophysical interaction between one or more calcium ion(s) and a biological molecule, such as a protein. Calcium binding with proteins often involves interaction of the ion(s) with a specific region, domain, or motif (e.g., EF-Hand) that supports protein structure or induces an alteration of protein activity in enzymatic or cell signaling cascades.
C21217	Synuclein_Family	Protein_Family	Synuclein Family	Small, soluble Synuclein Family proteins are a group of highly conserved post-transcriptionally modified Alpha, Beta, and Gamma proteins expressed primarily in neural tissue and often localized near synaptic vesicles. Synucleins may inhibit PLD2 and regulate vesicular transport. In the N-terminal portion, synucleins have a conserved repeated 11-residue amphipathic alpha-helical motif similar to the lipid-binding A2 domain of apolipoproteins. Synucleins also contain several repeated variations of a highly conserved KTKEGV domain, also present in rho family proteins. In brain, synucleins may be phosphorylated by Ca2+ calmodulin protein kinase II. Synucleins are overexpressed in breast carcinomas and mutations are associated with neurodegenerative illnesses.
C21218	Synuclein_Gamma	Protein_with_Unknown_or_Unclassified_Function	Synuclein Gamma|Breast Cancer-Specific Gene 1 Protein|Breast Cancer-Specific Protein 1|Gamma-Synuclein|Persyn|SNCG|Synoretin	Encoded by human SNCG Gene (Synuclein Family), the highly conserved 127-amino acid 13 kD cytoplasmic Gamma-Synuclein is similar to the amyloid protein nonamyloid beta fragment and to alpha-synuclein and beta-synuclein. SNCG is expressed in brain, heart, skeletal muscle, ovary, testis, colon, spleen, pancreas, kidney and lung. Gamma-Synuclein seems to play a role in neurofilament network integrity and may modulate axonal architecture; it may increase the susceptibility of neurofilament-H to calcium-dependent proteases and may also modulate the keratin network in skin. Phosphorylation by GRK5 appears to occur on residues distinct from other kinase target residues. Gamma-Synuclein is likely involved in the pathogenesis of neurodegenerative diseases and SNCG is expressed at very high level in advanced infiltrating breast cancer. (from Swiss-Prot, OMIM, and NCI)
C21219	Stromal_Interaction_Molecule-1	Transmembrane_Protein	Stromal Interaction Molecule 1|STIM1	Encoded by human STIM1 Gene, ubiquitously expressed 685-amino acid 77.5 kD (precursor) Stromal Interaction Molecule 1 Protein is a potential glycosylated cell surface type 1 transmembrane protein that influences the survival or proliferation of B cell precursors and may act as an adhesion molecule in hematopoiesis by mediating attachment to stromal cells. Phosphorylated mainly on serine residues, the protein contains a predicted signal peptide, a transmembrane helix, and one SAM domain. STIM1 oligomerizes with STIM2 and cell binding may require Mn(II). Defects in STIM1 may cause rhabdomyosarcoma and rhabdoid tumors. (NCI)
C21220	PIK3CA_Gene	Phosphoinositol_Kinase_Family_Gene	PIK3CA Gene|PIK3CA|Phosphatidylinositol 3-Kinase, Catalytic Subunit Gene|Phosphoinositide-3-Kinase, Catalytic, Alpha Polypeptide Gene|p110-Alpha Gene	The PIK3CA gene encodes Phosphoinositide-3-Kinase, Catalytic, Alpha Polypeptide, which belongs to the PI3/PI4-kinase family. Phosphatidylinositol 3 Kinase is a heterodimer of a P110 (catalytic) and a P85 (regulatory) subunit. It phosphorylates PTDINS, PTDINS4P and PTDINS(4,5)P2 with a preference for PTDINS(4,5)P2. (from Swiss-Prot)
C21221	DCK_Gene	Kinase_Family_Gene	DCK Gene|DCK|Deoxycytidine Kinase Gene	The DCK gene encodes Deoxycytidine Kinase, which is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity. (from LocusLink)
C21222	MAP2K1_Gene	Signaling_Pathway_Gene	MAP2K1 Gene|MAP2K1|MAPKK1|MEK1|MKK1|Mitogen-Activated Protein Kinase Kinase 1 Gene|PRKMK1	Human MAP2K1 Gene (DSPK/MAP2K Family) encodes 392-aa 43-kDa MAP2K1 Protein, a component/ regulator of the RAS/MAPK intracellular signaling pathway and critical activating protein kinase of MAP kinases such as ERK1 and ERK2 in response to a wide variety of extra- and intracellular signals in processes such as proliferation, differentiation, transcription regulation, and development. MAP kinases act as integration points for multiple biochemical signals. Dependent on Ser/Thr phosphorylation by MAP kinase kinase kinases (RAF/MEKK1), MAP2K1 catalyzes phosphorylation of Thr and Tyr in MAP kinase Thr-Glu-Tyr sequences. p53 activates NFKB through a RAF/MAP2K1/p90(RSK) pathway. (NCI)
C21223	RIPK1_Gene	Serine-Threonine_Protein_Kinase_Gene	RIPK1 Gene|RIP|RIPK1|Receptor (TNFRSF)-Interacting Serine-Threonine Kinase 1 Gene	Human RIPK1 Gene at 17q23-q24 encodes 74-kDa Receptor-Interacting Serine/Threonine Kinase 1, able to associate with Fas/APO-1 and induce cell death. RIP interacts with the cytoplasmic domain of FAS, and with TNFR1 through the adaptor proteins TRADD and TRAFs 1, 2, and 3. (NCI)
C21224	Anchorage-Independent_Growth	Cancer_Cell_Growth	Anchorage-Independent Growth	Detached cell proliferation. (NCI)
C21225	Transforming_Acidic_Coiled-Coil_Containing_Protein-1	Nuclear_Protein	Transforming Acidic Coiled-Coil-Containing Protein 1|Acidic Coiled-Coil Protein 1|TACC1|TACC1 Protein	Encoded by human TACC1 Gene (TACC Family), TACC1 Protein is expressed during early embryogenesis as an 805-amino acid 87.8 kD protein rich in serine, proline, and acidic residues, with a 20-amino acid N-terminus rich in tryptophan, and containing two nuclear localization signals but no DNA- or RNA-binding domains. A 200-residue C-terminus with extensive alpha-helical segments is expected to adopt a coiled-coil structure. Although the nuclear protein is concentrated at centrosomes and interacts with microtubules and tubulin, its function is not yet determined. (from Swiss-Prot, OMIM, and NCI)
C21226	MAPK3_Gene	Signaling_Pathway_Gene	MAPK3 Gene|ERK1|MAPK3|Mitogen-Activated Protein Kinase 3 Gene|P44ERK1|P44MAPK	Human MAPK3 Gene (MAPK Family) encodes MAP Kinase 3 (p44MAPK, ERK1), a Ser/Thr kinase activated in response to extracellular stimuli and widely involved in signal transduction as an integration point for multiple biochemical signals and as part of complex protein kinase cascades involved in a cell proliferation, differentiation, transcription regulation, and development. Phosphorylated/activated by upstream kinases, MAPK3 forms dimers with phosphorylated and unphosphorylated ERK partners, translocates to the nucleus and phosphorylates target transcription factors. (NCI)
C21227	MAPK1_Gene	Signaling_Pathway_Gene	MAPK1 Gene|ERK|ERK2|ERT1|MAPK1|MAPK2|Mitogen-Activated Protein Kinase 1 Gene|P41MAPK|P42MAPK|PRKM1|PRKM2	Human MAPK1 Gene (MAPK Family) encodes alternative p40 and p41 isoforms of Mitogen-Activated Protein Kinase 1, a proline-directed Ser/Thr kinase activated in response to extracellular stimuli and widely involved in signal transduction as an integration point for multiple biochemical signals and as part of complex protein kinase cascades involved in a cell proliferation, differentiation, transcription regulation, and development. Autophosphorylated and phosphorylated/activated by upstream kinases on threonine and tyrosine residues, MAPK1 forms dimers with phosphorylated and unphosphorylated ERK partners, translocates to the nucleus and phosphorylates target transcription factors. MAPK1 phosphorylates MAP2, MBP, and ELK-1. (NCI)
C21228	MAPK8_Gene	Signaling_Pathway_Gene	MAPK8 Gene|JNK|JNK1|JNK1A2|JNK21B1/2|MAP Kinase 8 Gene|MAPK8|Mitogen-Activated Protein Kinase 8 Gene|PRKM8|SAPK1	Human MAPK8 Gene (MAPK Family) encodes alternative isoforms (alpha-1, -2, beta-1, -2) of MAP Kinase 8, a stress/cytokine-induced Ser/Thr kinase that acts as an integration point for multiple biochemical signals involved in target transcription factor regulation, such as c-Jun and ATF2. Beta-1 binds c-Jun; alpha-1, -2, and beta-2 bind c-Jun or ATF2. Inhibited by dual specificity phosphatases, and phosphothreonine/tyrosine activated by a Ras-dependent dual specificity MAP2K4/MAP2K7 cascade, MAPK8 mediates immediate-early gene expression. MAPK8 binds scaffolding proteins MAPK8IP1/2/3. MAPK8/UV-induced apoptosis appears related to cytochrome c-mediated cell death. MAPK8 activation by TNF-alpha induces apoptosis. MAPK8 appears to be required for T-helper cell differentiation into Th1 cells. (NCI)
C21229	TYMS_Gene	Methyltransferase_Gene	TYMS Gene|TMS|TS|TYMS|Thymidylate Synthase Gene	The 7-exon 30-kb human TYMS Gene (Thymidylate Synthase Family) encodes 312-aa 36-kDa homodimeric Thymidylate Synthase, a transferase involved in TTP/deoxyribonucleotide biosynthesis that catalyzes MTHF/dUMP conversion to dihydrofolate/dTMP TYMS does not contain a TATA, CAAT, or GC box; intron 1 has 3 CG boxes. Polymorphic 5-prime UTR triple tandem repeated CGCCGCG sequences can form stem-loop secondary structures that affect TYMS activity through translation efficiency. Several tripeptide, tetrapeptide, and octapeptide TYMS sequences are invariant with E. coli, L. casei, and T4 phage; Pro194-Cys195-His196 binds 5-fluoro-2-prime deoxyuridylate. TYMS is considered the primary site of action for 5-fluorouracil and some folate analogs. Competing with MTHFR for MTHF, TYMS maintains the dTMP pool for DNA replication and repair. (NCI)
C21230	G1-S_Arrest	Cell_Cycle_Arrest	G1/S Arrest|G1-S Arrest	G1-S Arrest consists of cellular biochemical mechanisms, responsive to diverse governing conditions (DNA damage, contact inhibition, growth factors, etc.), that control cellular commitment at the G1 restriction point to DNA replication and the proliferative cycle. G1 to S is controlled by de/phosphorylated cyclin/CDK complexes. During G1, cycD/CDK phosphorylation of Rb/HDAC repressor permits E2F/DP1 transcription of genes that promote the G1/S switch and DNA replication. p53 induces p21 inhibition of cycD/CDK; Mdm2 inhibits p53/p21. TGF-b induces p15 inhibition of cycD/CDK. cAMP induces p27 inhibition of cycD/CDK. GSK3b induction of cycD degradation, and INK4, Kip, and Cdc25A regulate cycD/CDK activity.
C21231	Trefoil_Family	Protein_Family	Trefoil Family	These proteins are encoded by members of the trefoil family genes. They are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain containing three conserved intrachain disulfide bonds. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of the epithelium. (NCI)
C21232	MGMT_Gene	Regulatory_Gene	MGMT Gene|MGMT|Methylguanine-DNA Methyltransferase Gene|O-6-Methylguanine-DNA Methyltransferase Gene	Human MGMT Gene (MGMT Family) encodes 207-aa 22-kDa O-6-Methylguanine-DNA Methyltransferase, a unique and ubiquitous DNA repair enzyme that acts on alkylated guanine and other methylated DNA moieties. O(6)-alkylguanine is the major mutagenic and carcinogenic adduct lesion in DNA, induced by simple alkylating mutagens because of its preference for pairing with thymine during DNA replication. Unlike true enzymes, MGMT accepts the O-6 alkyl group from the lesion to a cysteine acceptor residue in the enzyme repairing the alkylated DNA in a stoichiometric second-order suicide reaction; the enzyme is irreversibly inactivated. (NCI)
C21233	TSG101_Gene	Regulatory_Gene	TSG101 Gene|TSG10|TSG101|Tumor Susceptibility Gene 101 Gene	Important for genomic stability and cell cycle regulation, human TSG101 Gene at 11p15.2-p15.1 encodes a 42.8 kD 381-amino acid Tumor Susceptibility Gene 101 Protein, 94% identical to the mouse protein. Expressed in heart, brain, placenta, lung, liver, kidney, and pancreas, shorter isoforms occur in breast cancers and other tumors. A negative growth and differentiation regulator through association with p21, cytoplasmic TSG101 protein may be a negative ubiquitin regulator; the ubiquitin enzyme-2 variant domain binds to ubiquitin. Nuclear protein, depending on cell cycle stage, interacts with DMAP1. The coiled-coil domain interacts with the cytosolic phosphoprotein Stathmin. TSG101 functions in vacuolar protein sorting and viral budding. Mutations and alternative splicing occur at high frequency in breast cancer during tumorigenesis or progression. (from LocusLink 7251, Swiss-Prot Q99816, OMIM 601387, and NCI)
C21234	CKB_Gene	Kinase_Family_Gene	CKB Gene|CKB|CKBB|Creatine Kinase Gene|Creatine kinase, Brain Gene	Human CKB Gene (ATP:Guanido Phosphotransferase Family) encodes 381-aa 43-kDa cytoplasmic homodimer or heterodimer Creatine Kinase, a transferase involved in energy homeostasis that primarily catalyzes reversible formation of ATP and creatine from phosphocreatine. Important in muscle contraction, the reaction stores ATP energy as phosphocreatine. Three cytoplasmic isoenzymes have been identified in human tissues: MM from skeletal muscle, MB from myocardial tissue and BB from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins. (NCI)
C21235	TNKS_Gene	Telomere_Maintenance_Gene	TNKS Gene|PARPL|TIN1|TINF1|TNKS|TNKS1|Tankyrase Gene|Tankyrase, TRF1-Interacting Ankyrin-Related ADP-Ribose Polymerase Gene	Human TNKS Gene (PARP Family) encodes 2 alternative isoforms of ADP-ribosylated 142-kDa ubiquitous Tankyrase; the central domain contains 24 ANK repeats, a motif that mediates protein-protein interactions, and a domain responsible for binding to TRF1; similar to the PARP catalytic domain, the C-terminus has PARP activity. TNKS oligomerizes with TNKS2. TNKS binds via the ANK repeats to the telomeric TRF1 N-terminus and regulates telomere length by inhibiting telomerase; ADP-ribosylation of TRF1 by TNKS may open the telomeric complex, allowing access to telomerase.  Interacting with the cytoplasmic domain of LNPEP/Otase, cytoplasmic TNKS may regulate the subcellular distribution of juxtanuclear SLC2A4/GLUT4-vesicles. Upon insulin-stimulation, TNKS is serine phosphorylated by MAPK kinases. (NCI)
C21236	TYRP1_Gene	Regulatory_Gene	TYRP1 Gene|CAS2|CATB|GP75|TRP|TYRP1|Tyrosinase-Related Protein 1 Gene	Expressed in melanocytes, 7-exon 24-kb human TYRP1 Gene (Tyrosinase Family) encodes 537-aa 61-kDa (precursor) type I membrane-spanning glycoprotein Tyrosinase-Related Protein 1, a catalase (no tyrosinase activity) with conserved Cys and His residues involved in oxidation of DHICA to melanochrome in premelanosomes. During melanin synthesis, hydroperoxides are produced during autooxidation of melanin precursor indoles by oxygen; catalase increases the yield of melanin. (NCI)
C21237	Tumor_Susceptibility_Gene-101_Protein	Regulatory_Protein	Tumor Susceptibility Gene 101 Protein|TSG101	Encoded by human TSG101 Gene and expressed in heart, brain, placenta, lung, liver, kidney, and pancreas, 390-amino acid 44 kD cytoplasmic Tumor Susceptibility Gene 101 Protein appears important for genomic stability and cell cycle regulation. A negative growth or differentiation regulator through p21 association and ubiquitin-conjugating enzyme homolog, TSG101 protein may be negative ubiquitin regulator or act in protein-ubiquitin conjugate removal. Nuclear TSG101 protein interacts with DMAP1; the coiled-coil domain interacts with cytosolic phosphoprotein Stathmin. TSG101 functions in vacuolar protein sorting and viral budding. The ubiquitin enzyme-2 variant domain binds to ubiquitin and to the p6 domain PTAP motif of HIV-1 Gag protein. Mutations occur at high frequency in breast cancer during tumorigenesis or progression. (from Swiss-Prot, OMIM, and NCI)
C21239	PSMD10_Gene	Regulatory_Gene	PSMD10 Gene|PSMD10|Proteasome (Prosome, Macropain) 26S Subunit, Non-ATPase, 10 Gene|Proteasome 26S Subunit Non-ATPase 10 Gene	The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. This gene encodes a non-ATPase subunit of the 19S regulator. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. (from LocusLink)
C21240	Translation_Process_Gene	Gene	Translation Process Gene	Genes that encode products which participate in translation, a complex mechanism that occurs on ribosomes. During this process, a peptide or protein is synthesized by utilizing an mRNA transcript to specify the sequence of amino acids in the resulting polypeptide. There are numerous translation process genes, as the synthesis of polypeptides requires ribosomal RNA, transfer RNA, GTP and proteins involved specifically in the activation of amino acids, initiation of synthesis, elongation and termination of synthesis.
C21241	Replication_Process	Retired_Concepts	Replication Process
C21242	Vacuolar_Protein_Sorting	Membrane_Protein_Traffic	Vacuolar Protein Sorting|VPS	Vacuolar Protein Sorting consists of subcellular and biochemical mechanisms involving cell membranes that govern the subcellular location of certain membrane bound or associated proteins.
C21243	Ubiquitinated_Protein_Degradation	Protein_Degradation	Ubiquitinated Protein Degradation|Removal of Protein-Ubiquitin Conjugate	Ubiquitinated Protein Degradation involves the regulated covalent conjugation of one or more ubiquitin residues to one or more sites on a protein that acts as a tag by which the protein-transport machinery ferries the targeted ubiquinated protein to the proteosome for proteolytic destruction.
C21244	HIV_Budding	Virus-Cell_Membrane_Interaction	HIV Budding	HIV Budding is a process in which newly generated viral RNA and protein complexes are assembled at, packaged in, and released from the cell surface membrane taking a piece of the cell membrane to form their own viral membranes. To bud from infected cells, HIV-1 employs several host proteins such as endosomal sorting protein Tsg101, which functions in the Vps pathway. The L domain (PTAP) in the p6 domain of HIV-1 Gag interacts with the N-terminal domain of TSG101; the Vps28-binding domain of TSG101 inhibits budding.
C21245	TSSC1_Protein	Protein_with_Unknown_or_Unclassified_Function	Tumor Suppressing Subtransferable Candidate 1 Protein|TSSC1	Encoded by human TSSC1 Gene, 387-amino acid 44 kD Tumor Suppressing Subtransferable Candidate 1 Protein is similar to Rb-Associated Protein p48 and chromatin assembly factor CAF1. The gene is located in an imprinted domain associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. (from Swiss-Prot and NCI)
C21246	TSSC3_Protein	Protein_with_Unknown_or_Unclassified_Function	Tumor Suppressing Subtransferable Candidate 3 Protein|BRW1C|BWR1C|HLDA2|IPL|PHLDA2|TSSC3	Encoded by human TSSC3 Gene, 152-amino acid 17 kD TSSC3 Protein is expressed in fetal and adult liver, lung, and kidney, placenta, and adult pancreas. With similarity to TDAG51, essential for FAS expression and susceptibility to apoptosis, TSSC3 may be involved in susceptibility to apoptosis. Mouse Tssc3 encodes a small cytoplasmic protein with a pleckstrin-homology (PH) domain. (from Swiss-Prot, OMIM, and NCI)
C21247	WNT-3_Protein	WNT_Family_Protein	WNT-3 Protein|INT4|WNT-3 Proto-Oncogene Protein|WNT3|Wingless-Type MMTV Integration Site Family, Member 3 Protein	Encoded by human WNT3 Gene (WNT Family), 355-amino acid 39.6 kD (precursor) WNT-3 Protein is a wingless (Drosophila) homolog with 98% amino acid identity to mouse Wnt3 protein and 84% to human WNT3A protein. Highly-conserved structurally related WNT proteins are 350-400 amino acid, cysteine-rich, short-range putative paracrine signaling glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. Wnt3 is required in mouse primary axis formation and anterior-posterior neural patterning in the ectoderm. This protein may play a role in some cancers through activation of the WNT-beta-catenin-TCF signaling pathway. (from Swiss-Prot, OMIM, and NCI)
C21248	HPR_Gene	Gene_with_Unknown_or_Unclassified_Function	HPR Gene|HPR|Haptoglobin-Related Protein Gene	Human HPR Gene (Peptidase S1 Family) at 16q22.1 encodes Haptoglobin-Related Protein (trypanosome lytic factor), with one sushi domain, which confers resistance to Trypanosome brucei.  HPR or HPR-like epitopes are expressed in human breast carcinoma.  Expression of HPR epitopes was associated with earlier recurrence, and multivariate analysis showed that HPR-epitope expression was an independent prognostic factor.
C21249	WNT-10B_Protein	WNT_Family_Protein	WNT-10B Protein|WNT-12 Protein|WNT10B|Wingless-Type MMTV Integration Site Family, Member 10B Protein	Encoded by human WNT10B Gene (WNT Family), 389-amino acid 43 kD (precursor) WNT-10B Protein is expressed in most adult tissues; heart and skeletal muscle (highest), brain (low; infant brain higher than adult). Highly-conserved structurally related WNT proteins are 350-400 amino acid, cysteine-rich, short-range putative paracrine signaling glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. WNT10B may govern adipogenesis: maintaining undifferentiated preadipocytes through inhibition of adipogenic transcription factors CEBPA and PPAR-gamma. WNT signaling blockage by axin induces these cells to differentiate into adipocytes. This pathway may also affect mesodermal cell fate determination. (from Swiss-Prot, OMIM, and NCI)
C21250	RTN4_Gene	Regulatory_Gene	RTN4 Gene|ASY|KIAA0886|NI220/250|NOGO|NOGOA|NOGOB|NOGOC|NSP-CL|RTN4|Reticulon 4 Gene	Expressed in CNS oligodendrocytes by human RTN4 Gene (Reticulon Family), Reticulon 4 A, B, and C (NOGO) is a high molecular weight transmembrane inhibitor of neurite out-growth found in CNS myelin. Reticulon 4 consists of a putative large extracellular domain that inhibits axonal extension with seven predicted N-linked glycosylation sites, two or three transmembrane domains, and a short C-terminal region similar to neuroendocrine-specific proteins and other reticulons. (NCI)
C21251	Zinc_Finger_Protein-147	E3_Ubiquitin_Ligase	Zinc Finger Protein 147|EFP|Estrogen-Responsive Finger Protein|TRIM25|Tripartite Motif Protein TRIM25|Tripartite Motif-Containing 25|Z147|ZNF147|Zinc Finger Protein-147	Encoded by human ZNF147 Gene (TRIM Family, RING Finger Family), the ubiquitous 630-amino acid 71 kD cytoplasmic estrogen-responsive Zinc Finger Protein 147 has potential DNA-binding and dimerization-transactivation domains, which suggest that ZNF147 may act as a transcription factor similar to other TRIM family members. The TRIM motif includes three zinc-binding domains, a SPRY domain, a RING, a B-Box Type 1 and Type 2, and a coiled-coil region. Zinc Finger Protein 147 is a RING-finger-dependent ubiquitin ligase (E3) that targets proteolysis of 14-3-3-sigma, a negative cell cycle regulator that causes G2 arrest. Lack of EFP function results in 14-3-3-sigma accumulation; 14-3-3-sigma is a target for proteolysis by EFP, leading to cell proliferation. (from Swiss-Prot, LocusLink, OMIM, and NCI)
C21252	CENPF_Gene	Cell_Cycle_Gene	CENPF Gene|CENF|CENPF|Centromere Protein F Gene|PRO1779	This gene encodes a protein that associates with the centromere-kinetochore complex. The protein is a component of the nuclear matrix during the G2 phase of interphase. In late G2 the protein associates with the kinetochore and maintains this association through early anaphase. It localizes to the spindle mid-zone and the intracellular bridge in late anaphase and telophase, respectively, and is thought to be subsequently degraded. The localization of this protein suggests that it may play a role in chromosome segregation during mitosis. It is thought to form either a homodimer or heterodimer. Autoantibodies against this protein have been found in patients with cancer or graft versus host disease. (LocusLink)
C21253	ATP_Binding_Cassette_Transporter-G2	ABC_Transporter	ATP-Binding Cassette, Sub-Family G, Member 2|ABCG2|ATP Binding Cassette Transporter G2|Breast Cancer Resistance Protein|Mitoxantrone Resistance Protein|Placenta Specific MDR Protein|Placenta-Specific ATP-Binding Cassette Transporter	Encoded by human ABCG2 Gene and highly expressed in the placenta, the 655-amino acid 72 kD ATP Binding Cassette Transporter G2 Protein (ABC Family) functions as a membrane-associated homodimeric or homooligomeric xenobiotic transporter likely to be significant in multi-drug resistance.  Involved in trafficking biologic molecules across extra- and intracellular membranes, ATP-binding cassette membrane transporters comprise seven subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White (ABCG).  Related to White (Drosophila) and ADP1 (Yeast), ABCG2 protein confers resistance to mitoxantrone, doxorubicin, and daunorubicin, reduces intracellular anthracycline and daunorubicin accumulation, and causes an ATP-dependent enhancement of rhodamine-123 efflux.  (from SWISS-PROT, OMIM, and NCI)
C21254	E3_Ubiquitin_Ligase	Ligase	E3 Ubiquitin Ligase	E3 Ubiquitin Ligases are ATP-dependent enzymes that catalyze the formation of a covalent bond between ubiquitous intracellular Ubiquitin proteins and other proteins, often to mark them for nonlysosomal proteasomal degradation or targeted transport. Ubiquitination requires sequential action of an activating enzyme (E1), a conjugating enzyme (E2), and a ligase (E3). Ubiquitin is coupled to protein by a peptide bond between the ubiquitin C-terminal glycine and protein lysine alpha-amino groups. Ubiquitination regulates protein degradation, chromatin remodeling, cell cycle progression, differentiation, gene expression, stress response, ribosome biogenesis, antigen presentation, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis.
C21255	TRIM_Family	Protein_Family	TRIM Family	Genes belonging to this family are implicated in several inherited human diseases (Familial Mediterranean Fever, X-linked Opitz/GBBB syndrome, and Mulibrey nanism) and in tumorigenesis. The TRIM proteins have a strong self-association ability that is mediated by their coiled-coil region. This property results in the formation of large protein complexes that identify diverse discrete sub-cellular structures. The formation of these cellular compartments is strictly dependent on the integrity of the Tripartite Motif. The TRIM proteins might play a role in cell sub-compartmentalization. (From http://www.tigem.it/research/Meroni.htm)
C21256	_14-3-3_Family	Protein_Family	14-3-3 Family	The 14-3-3 family of proteins mediates signal transduction by binding to phosphoserine-containing proteins. Two different binding motifs, RSXpSXP and RXY/FXpSXP, are present in nearly all known 14-3-3 binding proteins. The14-3-3 dimer binds tightly to single molecules containing tandem repeats of phosphoserine motifs, implicating bidentate association as a signaling mechanism with molecules such as Raf, BAD, and Cbl. (from OMIM)
C21257	Breast_Cancer_Suppressor-2	Protein_with_Unknown_or_Unclassified_Function	Breast Cancer Suppressor-2|BCDS2|BRCD2|Breast Cancer, Ductal 2	Inactivation of tumor suppressor BCDS2 Protein, encoded by Breast Cancer, Ductal 2 Gene, may represent a fundamental step in the pathogenesis of ductal carcinoma of the breast.  (OMIM, LocusLink, and NCI)
C21258	RTN1_Gene	Gene_with_Unknown_or_Unclassified_Function	RTN1 Gene|NSP|RTN1|Reticulon 1 Gene	Expressed from multiple promoters in neural and neuroendocrine tissues as 3.4-, 2.3-, and 1.8 kb transcripts, 275-kb human RTN1 Gene at 14q21-q22 encodes 3 isoforms (A, B, C) of Reticulon 1 with unique N termini, localized to ER membranes, and containing a reticulon domain and 2 large C-terminal hydrophobic domains. RTN1 may be involved in neuroendocrine secretion or membrane trafficking. RTN1-A produces a 776-aa 135-kD Ser/Pro-rich protein that contains multiple potential phosphorylation sites; RTN1-B is 356-aa and RTN1-C is 208-aa. RTN1-A and RTN1-B are phosphorylated and expression of RTN1-C is strongly correlated with neuronal differentiation. (NCI)
C21259	Neuroendocrine-Specific_Protein	Retired_Concepts	Neuroendocrine-Specific Protein|NSP|RTN1|Reticulon 1	Three different proteins encoded by the RTN1 gene. They are identical at their 3-prime ends but have unique amino termini. The common carboxyl-terminal region contains 2 large hydrophobic domains. The proteins are localized to membranes of the endoplasmic reticulum, leading to their proposed designation as 'reticulons.'  Their function is largely unknown. (from OMIM)
C21260	Death_Domain-Associated_Protein-6	Signaling_Protein	Death Domain-Associated Protein 6|DAXX|DAXX Protein|Death-Associated Protein 6|EAP1|ETS1 Associated Protein 1|FAS Death Domain-Associated Protein|hDAXX	Encoded by human DAXX Gene (DAXX Family), ubiquitous nuclear/cytoplasmic Death Domain-Associated Protein 6 is a 740-amino acid 81.4-kD sumoylated putative phosphohomomultimer with NLS, Glu-rich, and JNK activation domains. Bound to TGFBR2 and TNFRSF6 FAS death domain via C-terminus, DAXX bridges apoptotic FAS activation with caspase-independent ASK1 activation of JNK. HSPB1/HSP27-DAXX may block TNFRSF6/ASK1. DAXX co-represses transcription by recruitment to nucleoli or PML/POD/ND10 nuclear bodies through interaction with MCSR1 or PML and directly inhibits PAX3 and ETS1. As part of PAX5/CREBBP complex, DAXX may modulate PAX5 activity. DAXX binds to SLC2A4/GLUT4, CENPC1, UBE2I, PAX7, DEK, HDAC1, HDAC2, HDAC3, and histones H2A, H2B, H3, and H4. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C21261	MCAM_Gene	Gene_with_Unknown_or_Unclassified_Function	MCAM Gene|CD146|MCAM|MUC18|Melanoma Adhesive Molecule Gene	Active in neural crest cells during development and expressed primarily in neuroectodermal lineages and vascular smooth muscle in adult tissues, 14-kb 16-exon human MCAM Gene (Ig Superfamily) encodes 646-aa 72-kDa (precursor) Melanoma Adhesion Molecule, a cell surface type I membrane glycoprotein containing 3 Ig-like C2-type domains and 2 Ig-like V-type domains and a possible adhesion molecule homologue of cell adhesion molecule NCAM. (NCI)
C21262	BRCATA_Protein	Protein_with_Unknown_or_Unclassified_Function	Breast Cancer, 11;22 Translocation Associated Protein|BRCATA	The most frequently occurring constitutional reciprocal translocation in man is t(11;22)(q23;q11). The number of breast cancer cases is significantly higher than expected among the translocation carriers. The information should be useful in connection with counseling and screening. The BRCATA gene may be involved in the pathogenesis of breast cancer and is located at chromosome 11q23. (from OMIM 600048)
C21263	ITGB2_Gene	Cell_Adhesion_Molecule_Gene	ITGB2 Gene|CD18|ITGB2|Integrin, Beta 2 (Antigen CD18 (p95), Lymphocyte Function-Associated Antigen 1; Macrophage Antigen 1 (MAC-1) Beta Subunit) Gene|LAD|LCAMB|LFA-1|MF17	Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGB2 encodes the integrin beta 2 chain. Mutations in the beta-2 subunit of the leukocyte cell adhesion molecule have been found to cause the autosomal recessive disorder of neutrophil function known as leukocyte adhesion deficiency(from LocusLink)
C21264	ABCB6_Gene	Transport_Protein_Gene	ABCB6 Gene|ABC14|ABCB6|ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 6 Gene|EST45597|MTABC3|UMAT	The ABCB6 gene at 2q26 encodes a membrane-associated protein that is a member of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies and this protein is a member of the MDR/TAP subfamily. Members of this subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter, containing only 1 transmembrane domain and 1 nucleotide-binding domain, likely plays a role in mitochondrial function. ABCB6 may help maintain respiratory function and may also transport Fe/S clusters from mitochondria to the cytosol, thereby helping to prevent iron accumulation and DNA damage in the organelle. This gene is a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function. (NCI)
C21265	ABI2_Gene	Ligand_Binding_Protein_Gene	ABI2 Gene|ABI-2|ABI2|ABI2B|ABL Interactor 2 Gene|AIP-1|AblBP3|argBPIA	The ABL protein is a constitutively active tyrosine kinase that may regulate signal transduction events in the cytoplasm and processes in the nucleus. It is repressed by SH3 domains and possibly by other regions. The ABI-2 gene encodes a protein that is the substrate for ABL. This protein has an SH3 domain and interacts with the ABL. ABI-2 may function to coordinate the cytoplasmic and nuclear functions of the ABL. It modulates ABL transforming activity and functions as a tumor suppressor in mammalian cells. The ABI-2 gene is located at chromosome 2q33. (From LocusLink, OMIM)
C21266	ACK1_Gene	Non-Receptor_Tyrosine_Kinase_Gene	TNK2 Gene|ACK Gene|ACK1|ACK1 Gene|TNK2|Tyrosine Kinase, Non-Receptor, 2 Gene	The ACK1 gene encodes a non-receptor tyrosine kinase that binds CDC42 in its GTP-bound activated form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of CDC42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The encoded protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of CDC42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. The ACK1 gene is located at chromosome 3q29. (From LocusLink, OMIM and NCI)
C21267	ACVR1_Gene	Receptor_Serine-Threonine_Kinase_Gene	ACVR1 Gene|ACTRI|ACVR1|ACVRLK2|ALK2|Activin A Receptor, Type I Gene|Activin A Receptor, Type II-Like Kinase 2 Gene|Activin Receptor-Like Kinase 2 Gene|SKR1	Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The ACVR1 gene at 2q23-q24 encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. (LocusLink)
C21268	ACVR1B_Gene	Receptor_Serine-Threonine_Kinase_Gene	ACVR1B Gene|ACVR1B|ACVRLK4 Gene|ALK4 Gene|Activin A Receptor, Type IB Gene|Activin A Receptor, Type II-Like Kinase 4 Gene|Activin Receptor-Like Kinase 4 Gene	Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The ACVR1B gene at 12q13 encodes activin A type IB receptor. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a fourth variant potentially contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed. (From LocusLink, OMIM)
C21269	ACVRL1_Gene	Receptor_Serine-Threonine_Kinase_Gene	ACVRL1 Gene|ACVRL1|ACVRLK1|ALK-1|ALK1|Activin A Receptor, Type II-Like Kinase 1 Gene|Activin Receptor-Like Kinase 1 Gene|HHT|HHT2|ORW2|SKR3	Activin A receptor, type II-like 1 (also called activin receptor-like kinase 1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The ACVRL1 gene encodes a protein that shares similar domain structures with 3 other closely related ALK proteins (ALK2, ALK3, and ALK4) that together form a subfamily of receptor serine/threonine kinases. ACVRL1 is most highly expressed in human placenta and lung. ACVRL1 deficiency causes hemorrhagic telangiectasia type 2 (HHT2) also known as Rendu-Osler-Weber syndrome 2 (ORW2). The ACVRL1 gene is located at chromosome 12q11-q14. (From LocusLink, OMIM and NCI)
C21270	Ontology	Information_Sciences	Ontology	The word ontology has a long history in philosophy, in which it refers to the study of being as such. In information science, an ontology is an explicit formal specification of how to represent the objects, concepts and other entities that are assumed to exist in some area of interest and the relationships among them.
C21271	ACVR2_Gene	Receptor_Serine-Threonine_Kinase_Gene	ACVR2 Gene|ACTRII|ACVR2|Activin A Receptor, Type II Gene	Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The ACVR2 gene at 2q22.2-q23.3 encodes activin A type II receptor, and its sequence is 99% identical to that of the mouse type II receptor gene. (From LocusLink, OMIM)
C21272	Activin-A_Type-II_Receptor	Receptor_Serine-Threonine_Kinase	Activin A Type II Receptor|ACTR-II|ACTRIIA|ACVR2	Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Activin A type II receptor, encoded by the ACVR2 gene, is a receptor for activin A, activin B, and activin C and constitutively active kinase. Type I receptors are essential for transmembrane signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. (From LocusLink, OMIM and NCI)
C21273	ACVR2B_Gene	Receptor_Serine-Threonine_Kinase_Gene	ACVR2B Gene|ACVR2B|Activin A Receptor, Type IIB Gene	Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. The ACVR2 gene at chromosome 3p22 encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. (From LocusLink)
C21274	Activin-A_Type-IIB_Receptor	Receptor_Serine-Threonine_Kinase	Activin A Type IIB Receptor|ACTR-IIB|ACVR2B	Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A type IIB receptor, encoded by the ACVR2 gene and a receptor for activin A, activin B, and activin C, displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. (From LocusLink, Swiss_Prot)
C21275	Metalloproteinase_Gene	Protease_Gene	Metalloproteinase Gene	Metalloproteinase Genes encode Metalloproteinases (endopeptidases) that use a metal ion, normally zinc, in the catalytic process and preferentially cleave the Gln-Gly peptide bond. Metalloproteinases are inactivated by metal chelators. (NCI)
C21276	ADAMTS1_Gene	Metalloproteinase_Gene	ADAMTS1 Gene|A Disintegrin-Like and Metalloprotease (Reprolysin Type) with Thrombospondin Type 1 Motif, 1 Gene|ADAMTS1|METH1	The ADAMTS1 gene encodes a disintegrin and metalloproteinase with thrombospondin motif-1. The encoded protein is a member of the ADAMTS protein family and contains 2 disintegrin loops and 3 C-terminal TS motifs. It cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. It has anti-angiogenic activity and inhibits endothelial cell proliferation. This gene is composed of 9 exons and its expression may be associated with various inflammatory processes as well as development of cancer cachexia. It is likely to be necessary for normal growth, fertility, and organ morphology and function. The ADAMTS1 gene is located at chromosome 21q21.2. (From LocusLink)
C21277	ADAMTS1_Protein	Matrix_Metalloproteinase	A Disintegrin and Metalloprotease with Thrombospondin Motifs-1|A Disintegrin And Metalloproteinase With Thrombospondin Motifs 1|ADAM-TS1|ADAMTS1|METH-1	A disintegrin and metalloproteinase with thrombospondin motifs-1 (ADAMTS-1), encoded by the ADAMTS1 gene is a member of the ADAMTS protein family. It cleaves aggrecan at multiple sites and is differentially inhibited by metalloproteinase inhibitors. It has anti-angiogenic activity and inhibits endothelial cell proliferation. ADAMTS1 may be associated with various inflammatory processes as well as development of cancer cachexia. It is likely to be necessary for normal growth, fertility, and organ morphology and function. ADAMTS1 is secreted and associated with the extracellular matrix. The Spacer Domain and the TSP Type-1 Domains are important for a tight interaction with the extracellular matrix. ADAMTS1 is expressed as a 110-kD protein, an 85-kD protein after cleavage at the subtilisin site, or as a 67-kD protein, which is most abundant, generated by an additional processing event. (From LocusLink, Swiss_Prot and NCI)
C21278	ADAMTS9_Gene	Metalloproteinase_Gene	ADAMTS9 Gene|A Disintegrin-Like and Metalloprotease (Reprolysin Type) with Thrombospondin Type 1 Motif, 9 Gene|ADAMTS9	This gene encodes a disintegrin and metalloproteinase with thrombospondin motifs-9 (ADAMTS9), which is a member of the ADAMTS protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains four C-terminal TS motifs. This gene is localized to chromosome 3p14.3-p14.2, an area known to be lost in hereditary renal tumors. (LocusLink)
C21279	ADAMTS9_Protein	Matrix_Metalloproteinase	A Disintegrin and Metalloprotease with Thrombospondin Motifs-9|A Disintegrin and Metalloproteinase with Thrombospondin Motifs-9|ADAM-TS9|ADAMTS9	A disintegrin and metalloproteinase with thrombospondin motifs-9 (ADAMTS9), encoded by the ADAMTS9 gene, is a member of the ADAMTS protein family. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. This enzyme contains four C-terminal TS motifs. The spacer domain and the TSP Type-1 domains are important for a tight interaction with the extracellular matrix. The precursor is cleaved by a furin endopeptidase. Two isoforms, a long form and a short form, may be produced by alternative splicing. ADAMTS9 is secreted and associated with the extracellular matrix. It is highly expressed in all fetal tissues and expressed slightly in adult ovary, pancreas, heart, kidney, lung, placenta, spinal cord and brain. (From LocusLink, Swiss_Prot and NCI)
C21280	JUP_Gene	Cell_Adhesion_Molecule_Gene	JUP Gene|DP3|DPIII|JUP|Junction Plakoglobin Gene|PDGB|PKGB	The JUP gene encodes Plakoglobin (gamma-Catenin), which is a major soluble and membrane-associated cytoplasmic protein common to desmosomes and intermediate junctions. It associates with the cytoplasmic region of Desmoglein I and mediates the connection of cadherins to actin filaments and to other transmembrane and peripheral cytoplasmic proteins in epithelial adherens junctions. The cadherin-catenin complex interacts with EGFR; beta-Catenin and Plakoglobin are tyrosine phosphorylated by activated EGFR. APC binds to and regulates beta- and gamma-Catenin. Homologues of Drosophila armadillo, beta-Catenin and gamma-Catenin have analogous structures and functions in cell adhesion and the WNT signaling pathway. Several mutations of gamma-Catenin have transforming activity dependent on TCF/LEF and c-MYC function. Beta- and gamma-Catenin may have distinct roles in WNT signaling via differential effects on downstream target genes. (from OMIM 173325 and NCI)
C21281	Enzyme_Gene	Gene	Enzyme Gene	Enzyme Genes encode Enzymes, biological molecules (usually proteins) that possess catalytic activity. Catalytic RNA and catalytic DNA molecules have also been identified. (NCI)
C21282	Lyase_Gene	Enzyme_Gene	Lyase Gene	Lyase Genes encode Lyases, a class of enzymes that catalyze the hydration-dehydration cleavage of C-C, C-O, C-N, and other bonds by means other than hydrolysis or oxidation. (NCI)
C21283	ADCY9_Gene	Lyase_Gene	ADCY9 Gene|ADCY9|Adenylate Cyclase 9 Gene|KIAA0520 Gene	Adenylyl cyclases are membrane-associated enzymes that are expressed in most human tissues. These enzymes catalyze the formation of cAMP and are regulated by a family of G protein-coupled receptors, protein kinases, and calcium. The ADCY9 gene encodes adenylyl cyclase that is a widely distributed. It is stimulated by beta-adrenergic receptor activation but is insensitive to forskolin, calcium, and somatostatin. The ADCY9 gene is located at chromosome 16p13.3. (From LocusLink)
C21284	ADRA1A_Gene	Alpha_Adrenergic_Receptor_Gene	ADRA1A Gene|ADRA1A|ADRA1C|ADRA1C Gene|ADRA1L1|Adrenergic, Alpha-1A-, Receptor Gene	The ADRA1A gene encodes alpha-1A-adrenergic receptor that regulates smooth muscle contraction, cellular growth and apoptosis. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. Alternative splicing of the ADRA1A gene generates 4 transcript variants, which encode 4 different isoforms with distinct C termini but having similar ligand binding properties. The ADRA1A gene is located at chromosome 8p21-p11.2. (From LocusLink)
C21285	Alpha-1A_Adrenergic_Receptor	Alpha_Adrenergic_Receptor	Alpha-1A-Adrenergic Receptor|ADRA1A|ADRA1C|ADRA1L1|Adrenergic, Alpha-1A-, Receptor|Adrenergic, Alpha-1C-, Receptor|Alpha 1A-Adrenoceptor|Alpha-1C Adrenergic Receptor	Alpha-1A-adrenergic receptor, encoded by the ADRA1A gene, regulates smooth muscle contraction, cellular growth and apoptosis. Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This alpha-adrenergic receptor mediates its action by association with g proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(Q) and G(11) proteins. Alternative splicing of the ADRA1A gene generates 4 transcript variants, which encode 4 different isoforms with distinct C termini but having similar ligand binding properties. Its carboxyl-terminal SER or THR residues may be phosphorylated. (From LocusLink, Swiss_Prot and NCI)
C21286	ADRA2A_Gene	Alpha_Adrenergic_Receptor_Gene	ADRA2A Gene|ADRA2 Gene|ADRA2A|ADRAR|ADRAR Gene|Adrenergic, Alpha-2A-, Receptor Gene|Adrenoceptor, Alpha-2A Gene|Alpha-2-Adrenergic Receptor, Platelet Type Gene|Alpha-2A-Adrenergic Receptor Gene	The ADRA2A gene encodes alpha-2A-adrenergic receptor and it contains no introns in either its coding or untranslated sequences. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Both the alpha2A and alpha2C subtypes are required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibits transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulates neurotransmission at lower levels of nerve activity. The ADRA2A gene is located at chromosome 10q24-q26. (From LocusLink)
C21287	Alpha-2A_Adrenergic_Receptor	Alpha_Adrenergic_Receptor	Alpha-2A-Adrenergic Receptor|ADRA2A	Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. These receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. Alpha-2A-adrenergic receptor is encoded by the ADRA2A gene. Both the alpha2A and alpha2C subtypes are required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons. The alpha2A subtype inhibits transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulates neurotransmission at lower levels of nerve activity. (From LocusLink, Swiss_Prot and NCI)
C21288	ADRA2B_Gene	Alpha_Adrenergic_Receptor_Gene	ADRA2B Gene|ADRA2B|ADRA2L1|ADRA2L1 Gene|ADRA2RL1|ADRA2RL1 Gene|ADRARL1|ADRARL1 Gene|Adrenergic, Alpha-2B-, Receptor Gene|Alpha-2-Adrenergic Receptor-Like 1 Gene|Alpha-2B-Adrenergic Receptor Gene	Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The ADRA2B gene 2p13-q13 encodes the alpha2B subtype, which is associated with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. This polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. (From LocusLink)
C21289	Alpha-2B_Adrenergic_Receptor	Alpha_Adrenergic_Receptor	Alpha-2B-Adrenergic Receptor|ADRA2B|Alpha-2B Adrenoceptor	Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. The alpha2B subtype, encoded by the ADRA2B gene is associated with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, decreases G protein-coupled receptor kinase-mediated phosphorylation and desensitization. This polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. (From LocusLink)
C21290	CD14_Gene	Cell_Adhesion_Molecule_Gene	CD14 Gene|CD14|CD14 Antigen Gene	The CD14 gene encodes CD14 Antigen, a surface protein preferentially expressed on monocytes/macrophages. This protein binds lipopolysaccharide binding protein and recently has been shown to bind apoptotic cells. (from LocusLink)
C21291	CD28_Gene	Cell_Adhesion_Molecule_Gene	CD28 Gene|CD28|CD28 Antigen (Tp44) Gene|T44	Expressed by T lymphocytes, human CD28 Gene at 2q33 encodes CD28 Antigen, a glycosylated cell surface membrane protein with Ig homology and significant sequence identity with CTLA-4. Both bind to B7 ligand; CTLA-4 exhibits greater affinity. B7 antigen-presenting cells regulate T-cell activation by delivering antigen-independent stimulatory signals through CD28 and inhibitory signals through CTLA-4. CD28 undergoes tyrosine phosphorylation after interacting with B7.  Phosphorylation in the CD28 cytoplasmic domain allows recruitment of signaling proteins such as PI3K, GRB2, and GADS via their SH2 domains.  (NCI)
C21292	Beta_Adrenergic_Receptor_Gene	G_Protein-Coupled_Receptor_Gene	Beta Adrenergic Receptor Gene	Expressed in effector tissues innervated by postganglionic sympathetic adrenergic fibers, Beta Adrenergic Receptor Genes encode Beta Adrenergic Receptors, one of two major classes of adrenergic receptors (alpha and beta) based on their reactions to norepinephrine and epinephrine, on cellular effects of receptor activation, and on relative affinities and reactions to synthetic blocking or stimulating agents. Beta-adrenergic receptors respond to blocking agents such as propranolol and to activating agents such as isoproterenol. Beta-1 type receptors mediate lipolysis and increase cardiac rate and force of contraction; beta-2 type receptor activation promotes bronchial and vascular smooth muscle relaxation. When coupled to adenylate cyclase through Gs protein, Beta Adrenergic Receptor stimulation results in increased intracellular cyclic AMP. (NCI)
C21293	ADRB2_Gene	Beta_Adrenergic_Receptor_Gene	ADRB2 Gene|ADRB2|ADRB2R|ADRBR|Adrenergic, Beta-2-, Receptor, Surface Gene|B2AR|BAR|Beta-2 Adrenergic Receptor Gene|Beta-2 Adrenoceptor Gene|Beta-Adrenergic Receptor Gene|Catecholamine Receptor Gene	The ADRB2 gene encodes beta-2-adrenergic receptor that is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. Beta-2 adrenergic receptor stimulates adenylyl cyclase activity. This gene contains no introns in either its coding or untranslated sequences. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. The ADRB2 gene is located at chromosome 5q32-q34. (From LocusLink)
C21294	LCP1_Gene	Ligand_Binding_Protein_Gene	LCP1 Gene|CP64|L-Plastin Gene|LC64P|LCP1|Lymphocyte Cytosolic Protein 1 (L-Plastin) Gene|PLS2	Expressed as a 3.7-kb mRNA in hemopoietic cell lineages, 90-kb 16-exon human LCP1 Gene encodes 627-aa 70-kDa monomeric phosphorylated L-Plastin, a conserved cytoplasmic actin-binding protein identical to IL2-stimulated phosphoprotein p65 in T-cells and containing a blocked N-terminus, 2 EF-hand calcium-binding domains, a calmodulin-binding site, 4 calponin-homology (CH) domains, and two tandem actin-binding domains. (NCI)
C21295	Ligand_Binding_Protein_Gene	Gene	Ligand Binding Protein Gene	Ligand Binding Protein Genes encode Ligand Binding Proteins, a large class of diverse proteins for which a major function appears to be (typically high affinity) binding of some ligand for solubility, transport, bioactivity regulation, or other nonenzymatic process. Ligand interaction often alters protein molecular conformation and function. (NCI)
C21296	VCL_Gene	Ligand_Binding_Protein_Gene	VCL Gene|CP64|VCL|Vinculin Gene	A single human tumor suppressor VCL Gene at 10q22.1-q23 encodes a 1,066-amino acid Vinculin with strong similarity to other vinculins and to alpha-catenins. Human and chicken sequences exhibit greater than 95% identity. As a result of alternative splicing, metavinculin contains additional 68-79 variable and highly conserved amino acids near the C-terminus. Involved in cell adhesion, vinculin is associated with the cytoplasmic face of adherens-type junctions and involved in anchoring F-actin to the plasma membrane. Vinculin is phosphorylated on serines, threonines, and tyrosines and is acylated by myristic acid and/or palmitic acid. Vinculin exhibits self-association properties and appears to be the major talin-binding protein in platelets; 150 kD metavinculin also interacts strongly with talin.  (Omim, Swiss-Prot, LocusLink, and NCI)
C21297	Beta-2_Adrenergic_Receptor	Beta_Adrenergic_Receptor	Beta-2-Adrenergic Receptor|ADRB2|ADRB2R|ADRBR|Adrenergic, Beta-2-, Receptor, Surface|B2AR|BAR|Beta-2 Adrenergic Receptor|Beta-2 Adrenoceptor|Beta-Adrenergic Receptor|Catecholamine Receptor	Encoded by human ADRB2 Gene (GPCR Family), Beta-2 Adrenergic Receptor directly associates with one of its effectors, class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. This signaling complex assembly ensures specific and rapid signaling by this G protein-coupled receptor that stimulates adenylyl cyclase activity. Polymorphisms, point mutations, and/or downregulation of ADRB2 are associated with nocturnal asthma, obesity, and type 2 diabetes. (From LocusLink)
C21298	RNA_Binding_Protein	Ligand_Binding_Protein	RNA Binding Protein	RNA Binding Proteins temporarily and non-covalently interact through intermolecular physical forces of attraction and spatial complementarity with RNA in a sequence-dependent or -independent fashion for transport, catalysis, localization, or modification of function.
C21299	Mitochondrial_ABC_Protein-3	ABC_Transporter	ATP-Binding Cassette, Sub-Family B, Member 6|ABCB6|Mitochondrial ABC Protein 3	ATP-Binding Cassette, Sub-Family B, Member 6, encoded by the ABCB6 gene, is a membrane-associated protein of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. It could be involved in the transport of heme from the mitochondria to the cytosol. This gene is a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function. (From LocusLink, Swiss_Prot and NCI)
C21300	ABL-Interactor_2_Protein	Ligand_Binding_Protein	ABL-Interactor 2|ABI2|ABL Binding Protein 3|ABL-Interactor Protein 2B	The ABL protein is a constitutively active tyrosine kinase that may regulate signal transduction events in the cytoplasm and processes in the nucleus. It is repressed by SH3 domains and possibly by other regions. ABL-Interactor 2, encoded by the ABI-2 gene, is the substrate for ABL. This protein has an SH3 domain and interacts with the ABL. ABI-2 may function to coordinate the cytoplasmic and nuclear functions of the ABL. It modulates ABL transforming activity and functions as a tumor suppressor in mammalian cells. (From LocusLink, OMIM)
C21301	ASCL1_Gene	Transcription_Coactivator_Gene	ASCL1 Gene|ASCL1|ASH1|Achaete-Scute Complex-Like 1 (Drosophila) Gene|HASH1|MASH1	Human ACSL1 Gene (bHLH/ASC Family) encodes 236-aa 25 kDa transcription activation factor Achaete-Scute Complex-Like 1 Protein, which binds efficiently to the E box (5 prime-CANNTG-3 prime) as a heterodimer with other bHLH proteins, such as E12/E47. ACSL1 regulates commitment and differentiation of specific olfactory and autonomic neuronal lineages.
C21302	ANP32B_Gene	Gene_with_Unknown_or_Unclassified_Function	ANP32B Gene|ANP32B|APRIL|Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family, Member B Gene|PAL31|PHAPI2|SSP29	Human oncogene Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family Member B Gene at 9q22.32 encodes PHAPI2, a product with similarity to PHAPI.  (Swiss-Prot, LocusLink, and NCI)
C21303	APS_Gene	Adaptor_Signaling_Protein_Gene	APS Gene|Adaptor Protein with Pleckstrin Homology and SRC Homology 2 Domains Gene	Human APS Gene at 7q22 encodes 85 kD APS Protein in 9 exons spanning at least 36.5 kb.  A 2.3 kb transcript is found in spleen, prostate, testis, uterus, small intestine, and skeletal muscle; a smaller transcript is found in peripheral blood leukocytes.  The 632-amino acid adaptor protein contains a PH domain, a SH2 domain, and a C-terminal tyrosine phosphorylation site.  APS is structurally similar to the T-cell adaptor protein/signal transducer LNK and is tyrosine-phosphorylated after BCR cross-linking.  APS associates with SHC regardless of BCR stimulation and with GRB2 after BCR stimulation.  (OMIM and NCI)
C21304	APCL_Gene	Signaling_Pathway_Gene	APC2 Gene|APC2|APCL|Adenomatosis Polyposis Coli 2 Gene	Human Adenomatous Polyposis Coli Like Gene at 19p13.3 encodes tumor suppressor APC2 Protein, similar to APC, which regulates formation of active Beta Catenin/TCF complexes.  (Swiss-Prot, LocusLink, and NCI)
C21305	AKAP9_Gene	Signaling_Pathway_Gene	AKAP9 Gene|A Kinase (PRKA) Anchor Protein (Yotiao) 9 Gene|AKAP350|AKAP450|AKAP9|CG-NAP|HYPERION|KIAA0803|YOTIAO	Human A Kinase Anchor Protein 9 Gene at 7q21-q22 is widely expressed as six alternatively spliced transcripts: isoform 1, 2, 3/CG-NAP, 4/Yotiao, 5, and 6/AKAP350.  An 11 kb transcript is expressed in skeletal muscle, pancreas, heart, placenta, and brain.  The full-length protein contains many coiled-coil regions.  Centrosomal, cytoskeletal, cytoplasmic, or associated with postsynaptic densities, AKAP9 appears to be a scaffolding protein for protein kinases and phosphatases.  AKAP9 interacts with the regulatory region of PKN, PP2A, PP1 and PKC Epsilon.  Highly expressed in the pancreas and at synapses, isoform 4/Yotiao interacts with a NMDA receptor NR1 subunit intracellular alternatively spliced C-terminus and may modulate synaptic transmission.  Yotiao binds to PP1and to PKA RII, indicating that it is an AKAP.  (OMIM, Swiss-Prot, and NCI)
C21306	AKAP12_Gene	Signaling_Pathway_Gene	AKAP12 Gene|A Kinase (PRKA) Anchor Protein (Gravin) 12 Gene|AKAP12|AKAP250	Human AKAP12 Gene at 6q24-q25 encodes A Kinase Anchor Protein 12, expressed in endothelial cells, but not platelets, or peripheral blood cells.  Two isoforms may be produced by alternative splicing.  The 1,780-amino acid cytoplasmic anchoring protein appears to mediate compartmentation of PKA and PKC in the cortical cytoskeleton.  Its amphipathic alpha helix binds to the PKA RII subunit and tethers the enzyme near its substrates.  Activated by lysopc, AKAP12 inhibits PKC.  Polybasic regions are involved in binding PKC.  (OMIM, Swiss-Prot, and NCI)
C21307	AKAP13_Gene	Signaling_Pathway_Gene	AKAP13 Gene|A Kinase (PRKA) Anchor Protein 13 Gene|AKAP13|BRX|BRX Gene|HT31|HT31 Gene|LBC|LBC Gene	The A-Kinase Anchor Proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. The AKAP13 gene at 15q24-q25 encodes A Kinase Anchor Protein 13. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway, and in addition function as protein kinase A-anchoring proteins. (From LocusLink and NCI)
C21308	ALDH1A2_Gene	Oxidoreductase_Gene	ALDH1A2 Gene|ALDH1A2|Aldehyde Dehydrogenase 1 Family, Member A2 Gene|RALDH(II)|RALDH-2|RALDH2|RALDH2 Gene	Human Aldehyde Dehydrogenase 1 Family Member A2 Gene at 15q21.1-q21.2 encodes a 499-amino acid putative cytoplasmic homotetrameric NAD-dependent retinaldehyde dehydrogenase, similar to class 1 aldehyde dehydrogenases that synthesizes retinoic acid from retinaldehyde.  The protein contains conserved aldehyde dehydrogenase motifs: a GXGXXXG motif NAD-binding domain, two peptide motifs, and cys301, critical for aldehyde group interaction.  ALDH1A2 and CYP26A1 regulate local retinoic acid levels that act as a signal in developing and adult tissues; CYP26A1 metabolizes retinoic acid.  In T-ALL, ectopically expressed TAL1 and LMO in T cells form a complex with GATA3 on the RALDH2-T promoter and activate transcription.  (OMIM, Swiss-Prot, and NCI)
C21309	AKR7A2_Gene	Oxidoreductase_Gene	AKR7A2 Gene|AFAR|AKR7|AKR7A2|Aldo-Keto Reductase Family 7, Member A2 (Aflatoxin Aldehyde Reductase) Gene	Human oncogene Aldo-Keto Reductase Family 7 Member A2 Gene at 1p35.1-p36.23 encodes the widely expressed 330-amino acid AFAR polypeptide similar to rat Afar, to a Shaker-related voltage-gated potassium channel, and to aldose reductase.  Aldoketoreductases (AKRs) detoxify aldehydes and ketones; AFAR is the principal liver reductase for 2-carboxybenzaldehyde and can metabolize Aflatoxin B1 protein-binding dihydrodiol.  AFAR may protect the liver against the toxic and carcinogenic effects of Aflatoxin B1.  (OMIM, Swiss-Prot, and NCI)
C21310	APRIN_Gene	Cell_Cycle_Gene	APRIN Gene|APRIN|AS3|Androgen-Induced Proliferation Inhibitor Gene|CG008|FLJ23236|KIAA0979	Human AS3 Gene encodes 1391-amino acid 158-kD Androgen-Induced Prostate Proliferative Shutoff Associated Protein, a likely androgen-induced tumor suppressor that mediates G0/G1 cell cycle arrest (androgen-induced proliferative shutoff). AS3 has putative transactivating features, protein-protein interaction motifs (coiled-coil and leucine zipper), and DNA-binding domains, suggesting that AS3 is a transcription factor. AS3 also has a protein-kinase motif, suggesting that it may phosphorylate a target protein.  (NCI)
C21311	ANGPT1_Gene	Chromogranin_Gene	ANGPT1 Gene|ANG1 Gene|ANGPT1|Angiopoietin 1 Gene|KIAA0003	Human Angiopoietin 1 Gene at 8q22.3-q23 encodes a 498-amino acid secreted glycoprotein ANGPT1 ligand for TIE2 receptor that contains a predicted coiled-coil domain and a fibrinogen-like C-terminus.  Its expression in developing blood vessels indicates an action in vascular development.  Antagonized by Angiopoietin-2, ANGPT1 activates endothelial TIE2 by inducing its tyrosine phosphorylation.  ANGPT1 structure differs from other angiogenic factors or ligands for receptor tyrosine kinases and its actions are distinct from VEGF, necessary for early stages of vascular development.  ANGPT1 acts in vascular remodeling, maturation, and stability.  ANGPT1 and TIE1 are critical for right side, but not left side, venous system development.  (OMIM, Swiss-Prot, and NCI)
C21312	ANGPT2_Gene	Chromogranin_Gene	ANGPT2 Gene|ANG-2 Gene|ANGPT2|Angiopoietin 2 Gene	Human Angiopoietin 2 Gene at 8p23.1 encodes a 68 kD 496-amino acid secreted homodimeric Angiopoietin 2 that contains a fibrinogen-like C-terminus.  ANG2 is nearly 60% identical to ANG1.  A 61 kD homodimeric alternative ANG2(443) product lacks 53 amino acids found in ANG2 encoded by exon B and part of the N-terminal coiled-coil domain.  Like ANG2 and ANG1, secreted ANG2(443) binds endothelial TIE2 receptor tyrosine kinase, but not TIE1.  ANG2(443) partially inhibits ANG2 and ANG1 binding to TIE2.  As an ANG1 and TIE2 antagonist, ANG2 may counteract blood vessel maturation or stability by loosening cell-matrix contacts and inducing endothelial apoptosis.  With VEGF, ANG2 may facilitate endothelial cell migration and proliferation.  In adults, ANGPT2 is only expressed at the sites of vascular remodeling.  (OMIM, Swiss-Prot, and NCI)
C21314	AMHR2_Gene	Receptor_Serine-Threonine_Kinase_Gene	AMHR2 Gene|AMHR|AMHR Gene|AMHR2|Anti-Mullerian Hormone Receptor, Type II Gene	Human Anti-Mullerian Hormone Receptor Type II Gene at 12q13 encodes a receptor for Anti-Mullerian Hormone within 11 exons.  Exons 1 to 3 encode the extracellular domain, exon 4 corresponds to the transmembrane domain, and the remaining exons encode the intracellular Ser/Thr kinase.  The 573-amino acid type II receptor does not appear to undergo alternative splicing.  Type II receptors bind ligand but require a type I receptor for signal transduction.  Anti-Mullerian Hormone (AMH/MIS/MIF), produced by Sertoli cells, induces regression of Mullerian ducts, which differentiate into the uterus and fallopian tubes.  Type I persistent Mullerian duct syndrome is caused by AMH gene mutation; type II syndrome is due to AMHR mutation.  (OMIM, Swiss-Prot, and NCI)
C21315	ASE-1_Gene	Gene_with_Unknown_or_Unclassified_Function	ASE-1 Gene|ASE-1|Antisense to ERCC-1|CAST|CD3-Epsilon-Associated Protein; Antisense to ERCC-1 Gene	The 3-prime terminus of human ERCC1, a DNA repair gene, overlaps the 3-prime end of Antisense to ERCC-1 Gene at 19q13.2-q13.3.  This exceptional type of overlap is conserved in mouse and even in yeast RAD10, an ERCC1 homolog, suggesting an important biologic function.  ASE1 appears to encode CD3-Epsilon-Associated Protein.  (OMIM and NCI)
C21316	ALOX15_Gene	Oxidoreductase_Gene	ALOX15 Gene|ALOX15|Arachidonate 15-Lipoxygenase Gene|LOG15 Gene	Human ALOX15 gene, a putative mutator gene, at 17p13.3 maps close to tumor-suppressor TP53 gene.  TP53 regulates ALOX15 in human and mouse.  Cytoplasmic ALOX15 protein (Lipoxygenase family) acts in leukotriene biosynthesis and is implicated in anti-inflammation, membrane remodeling, and cancer development or metastasis.  It converts arachidonic acid to 15s-hydroperoxyeicosatetraenoic acid.  (OMIM, Swiss-Prot, and NCI)
C21317	ARMET_Gene	Gene_with_Unknown_or_Unclassified_Function	ARMET Gene|ARMET|ARP|Arginine-Rich Mutated In Early Stage Tumors Gene	The 4.4-kb human ARMET Gene (ARMET/ARP Family) at 3p21.1 encodes a highly conserved potentially secreted 234-aa arginine-rich ARMET Protein with unknown function. The presence of a specific mutation changing codon 50 from ATG to AGG, or deletion of that codon, has been reported in a variety of solid tumors. (NCI)
C21318	Arrestin_Beta_1_Gene	Retired_Concepts	Arrestin, Beta 1 Gene
C21319	AMSH_Gene	Signaling_Pathway_Gene	STAMBP Gene|AMSH|STAM Binding Protein Gene|STAMBP	Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. The protein encoded by this gene binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. (LocusLink)
C21320	ARHH_Gene	G_Protein_Gene	RHOH Gene|ARHH|RAS Homolog Gene Family, Member H Gene|RHOH|TTF	Human oncogene RAS Homolog Gene Family Member H Gene at 4p13 encodes a 191-amino acid hemopoietic cell RHOH/TTF polypeptide on 2 exons spanning 35 kb.  Exon 2 contains the entire coding region, which encodes residues associated with binding and hydrolysis of GTP.  ARHH belongs to the small GTPase superfamily, RHO family; highest identity is found with RHO-like CDC42 protein.  ARHH is involved in a t(3;4)(q27;p11) chromosomal translocation with BCL6.  (OMIM, Swiss-Prot, and NCI)
C21321	Achaete-Scute_Complex-Like-1_Protein	Transcription_Factor	Achaete-Scute Complex-Like 1 Protein|ASCL1|ASH1|Achaete-Scute Complex Homolog-Like 1 Protein|Achaete-Scute Homolog 1 Protein|Human Achaete-Scute Homolog 1 Protein|MASH1|Mammalian Achaete-Scute Homolog 1	Encoded by human ACSL1 Gene (bHLH/ASC Family), 236-aa 25 kDa transcription activation factor Achaete-Scute Complex-Like 1 Protein binds efficiently to the E box (5 prime-CANNTG-3 prime) as a heterodimer with other bHLH proteins, such as E12/E47. ACSL1 regulates commitment and differentiation of specific olfactory and autonomic neuronal lineages.
C21322	Protein_with_Unknown_or_Unclassified_Function	Protein_Organized_by_Function	Protein with Unknown or Unclassified Function|Unclassified Protein	Encoded by Genes with Unknown or Unclassified Function, Proteins (or RNAs) with Unknown or Unclassified Function have currently unidentified or unspecified cellular functions. (NCI)
C21323	APS_Protein	Adaptor_Signaling_Protein	APS Protein|APS|Adaptor Protein Containing PH and SH2 Domains|Adaptor Protein with Pleckstrin Homology and SRC Homology 2 Domains	Encoded by human APS Gene, 85 kD APS Protein appears to be found in spleen, prostate, testis, uterus, small intestine, skeletal muscle, and peripheral blood leukocytes.  The 632-amino acid adaptor protein contains a PH domain, a SH2 domain, and a C-terminal tyrosine phosphorylation site.  APS is structurally similar to the T-cell adaptor protein/signal transducer LNK and is tyrosine-phosphorylated after BCR cross-linking.  APS associates with SHC regardless of BCR stimulation and with GRB2 after BCR stimulation.  (OMIM and NCI)
C21324	Adenomatous_Polyposis_Coli_Like_Protein	Signaling_Protein	Adenomatous Polyposis Coli Like Protein|APC2|APCL	Encoded by human APCL Gene, 2303-amino acid 244 kD tumor suppressor APCL Protein is similar to APC and regulates formation of active Beta-Catenin/TCF complexes.  (Swiss-Prot, LocusLink, and NCI)
C21325	A_Kinase_Anchor_Protein-9	Signaling_Protein	A Kinase Anchor Protein 9|A Kinase (PRKA) Anchor Protein (Yotiao) 9|A-Kinase Anchor Protein 350 kD|A-Kinase Anchor Protein 450 kD|AKAP 120 Like Protein|AKAP 350|AKAP 450|AKAP9|CG-NAP|Centrosome- and Golgi-Localized PKN-Associated Protein|Hyperion|PRKA9|Protein Kinase A Anchoring Protein 9|Yotiao	Encoded by human AKAP9 Gene, 3911-amino acid 454 kD A Kinase Anchor Protein 9 is widely expressed as alternative isoforms: 1, 2, 3/CG-NAP, 4/Yotiao, 5, and 6/AKAP350.  Full-length protein contains many coiled-coil regions.  Centrosomal, cytoskeletal, cytoplasmic, or associated with postsynaptic densities, AKAP9 appears to be a scaffolding protein for protein kinases and phosphatases.  AKAP9 interacts with the regulatory region of PKN, PP2A, PP1 and PKC Epsilon.  Highly expressed in the pancreas and at synapses, isoform 4/Yotiao interacts with a NMDA receptor NR1 subunit alternatively spliced intracellular C-terminus and may modulate synaptic transmission.  Yotiao binds to PP1 and PKA RII, indicating that it is an AKAP.  (OMIM, Swiss-Prot, and NCI)
C21326	A_Kinase_Anchor_Protein-12	Signaling_Protein	A Kinase Anchor Protein 12|A Kinase (PRKA) Anchor Protein 12|A-Kinase Anchor Protein, 250-kD|AKAP12|AKAP250|Gravin|Myasthenia Gravis Autoantigen Gravin Protein	Encoded by human AKAP12 Gene, A Kinase Anchor Protein 12 is expressed in endothelial cells, but not in platelets or peripheral blood cells.  The 1,781-amino acid 191 kD cytoplasmic anchoring protein appears to mediate compartmentation of PKA and PKC in the cortical cytoskeleton.  Its amphipathic alpha helix binds to the PKA RII subunit and tethers the enzyme near its substrates.  Activated by lysopc, AKAP12 inhibits PKC. Polybasic regions are involved in binding PKC.  (OMIM, Swiss-Prot, and NCI)
C21327	EZH2_Gene	Regulatory_Gene	EZH2 Gene|ENX-1|EZH1|EZH2|Enhancer of Zeste 2|Enhancer of Zeste Homolog 2 (Drosophila) Gene|MGC9169	Expressed in many tissues, human EZH2 Gene (EZ Family/PcG Family) encodes 746-aa 85-kDa nuclear Enhancer of Zeste Homolog 2 protein, containing a SET domain, that may be involved in regulation of gene transcription and chromatin structure in the hematopoietic and central nervous systems. PcG proteins form multimeric protein complexes involved in transcriptional repression over successive cell generations. EZH2 appears to associate with embryonic ectoderm development protein VAV1 and with ATRX via the SET domain. (NCI)
C21328	Computerized_Thermal_Imaging	Thermography	Computerized Thermal Imaging|CTI	A non-invasive imaging method that uses a thermal sensitive camera to capture a digital image based on heat radiating from the body. In trials for detection of breast cancer, computer-assisted interpretation of the digital image helps to determine whether a local abnormality in breast tissue temperature is present, which may indicate the presence of disease.
C21329	A_Kinase_Anchor_Protein-13	Guanine_Nucleotide_Exchange_Factor	A Kinase Anchor Protein 13|A-Kinase (PRKA) Anchor Protein 13|AKAP13|BRX|HT31|LBC|P47	Encoded by human oncogene AKAP13 Gene, 424-amino acid 49 kD A Kinase Anchor Protein 13 is a signal transduction RHO/RAC GEF involved in cytoskeletal organization and cell cycle progression.  Alpha helical hydrophilic LBC is conserved among vertebrates and expressed in skeletal muscle, heart, lung, and hematopoietic cells.  It contains phosphorylation sites, N-terminal DH and PH domains, and an N-terminal EF-hand motif.  LBC binds to PKA RII tethering it near substrates.  AKAP13 stimulates RHO/RAC, but not CDC42 or RAS.  In ovary, placenta, breast, and testis, 170 kD BRX contains a LBC region preceded by 3 novel regions; C-terminal regions 4 and 5 bind to the ESR1 ligand-binding domain.  BRX also binds RXR, PPAR, and THR.  Chimeric onco-LBC lacks the C-terminus, which promotes transforming activity.  Proto-LBC is membrane bound; onco-LBC is cytosolic.  (OMIM, Swiss-Prot, and NCI)
C21330	Aldehyde_Dehydrogenase-1A2	Oxidoreductase	Aldehyde Dehydrogenase 1A2|ALDH1A2|Aldehyde Dehydrogenase 1 Family Member A2|Aldehyde Dehydrogenase 1 Family, Member A2|RALDH(II)|RALDH-2|RALDH2|Retinaldehyde-Specific Dehydrogenase Type 2	Encoded by human ALDH1A2 Gene, Aldehyde Dehydrogenase 1A2 (ADH Family) is a 499-amino acid 54.8 kD putative cytoplasmic homotetrameric NAD-dependent retinaldehyde dehydrogenase, similar to class 1 aldehyde dehydrogenases that synthesizes retinoic acid from retinaldehyde.  The protein contains conserved aldehyde dehydrogenase motifs: GXGXXXG motif NAD-binding domain, two peptide motifs, and cys301, critical for aldehyde group interaction.  ALDH1A2 and CYP26A1 regulate local retinoic acid levels that act as a signal in developing and adult tissues; CYP26A1 metabolizes retinoic acid.  In T-ALL, ectopically expressed TAL1 and LMO in T cells form a complex with GATA3 on the RALDH2-T promoter and activate transcription.  (OMIM, Swiss-Prot, and NCI)
C21331	Aldo-Keto_Reductase-7	Oxidoreductase	Aldo-Keto Reductase 7|AFAR|AKR7|AKR7A2|Aflatoxin Aldehyde Reductase|Aflatoxin B1 Aldehyde Reductase 1|Aflatoxin B1-Aldehyde Reductase|Aldo-Keto Reductase Family 7 Member A2 Protein|Aldoketoreductase 7	Encoded by human oncogene AKR7A2 Gene, widely expressed 330-amino acid 36.6 kD AFAR polypeptide (Aldo/Keto Reductase 2 Family) is similar to rat Afar, to a Shaker-related voltage-gated potassium channel, and to aldose reductase. Aldoketoreductases (AKRs) detoxify aldehydes and ketones; AFAR is the principal liver reductase for 2-carboxybenzaldehyde and can metabolize Aflatoxin B1 protein-binding dihydrodiol.  AFAR may protect the liver against the toxic and carcinogenic effects of Aflatoxin B1.  (OMIM, Swiss-Prot, and NCI)
C21332	APRIN_Protein	Cell_Cycle_Protein	Androgen-Induced Prostate Proliferative Shutoff Associated Protein|APRIN	Encoded by human AS3 Gene, 1391-amino acid 158 kD AS3 Protein appears to be an androgen-induced tumor suppressor that mediates G0/G1 cell cycle arrest (androgen-induced proliferative shutoff). AS3 protein has putative transactivating features, protein-protein interaction motifs (coiled-coil and leucine zipper), and DNA-binding domains, suggesting that AS3 is a transcription factor. AS3 also has a protein-kinase motif, suggesting that it may phosphorylate a target protein.  (Swiss-Prot, OMIM, and NCI)
C21333	Annexin-A5_Protein	Ion_Channel_Protein	Annexin A5 Protein|ANXA5|Anchorin CII|Annexin V|CBP-I|Calphobindin I|Endonexin II|Lipocortin V|PAP-I|PP4|Placental Anticoagulant Protein I|Placental Protein 4|Thromboplastin Inhibitor|VAC-Alpha|Vascular Anticoagulant-Alpha	Encoded by human Annexin A5 Gene, Annexin A5 is a 35 kD 320-amino acid monomeric placental protein similar to PP4-X that contains 4 annexin repeats; some may bind calcium and phospholipid.  PP4 and PP4-X (Lipocortin family) are similar to lipocortin I and calpactin I.  PP4 is also an Annexin family member, Ca(2+)-dependent phospholipid binding proteins located on the plasma membrane cytosolic face.  PP4 forms a voltage-dependent membrane Ca(2+) channel; key amino acids act as selectivity filters and voltage sensors, regulating pore permeability to ions.  As an anticoagulant protein, PP4 acts as an indirect inhibitor of the blood coagulation cascade thromboplastin-specific complex.  PP4 may bind ATRX.  (OMIM, Swiss-Prot, and NCI)
C21334	Anti-Mullerian_Hormone_Receptor_Type-II	Receptor_Serine-Threonine_Kinase	Anti-Mullerian Hormone Receptor Type II|AMH Type II Receptor|AMHR|AMHR2|Anti-Mullerian Hormone Receptor|Anti-Mullerian Hormone Type II Receptor|MIS Type II Receptor|MISRII|MRII	Encoded by human AMHR2 Gene, the 573-amino acid 62.7 kD Anti-Mullerian Hormone Receptor Type II Ser/Thr protein kinase (TGFB Receptor Family) is a type I membrane protein.  Type II receptors bind ligand but require a type I receptor for signal transduction.  Anti-Mullerian Hormone (AMH/MIS/MIF), produced by Sertoli cells, induces regression of Mullerian ducts, which differentiate into the uterus and fallopian tubes.  Type I persistent Mullerian duct syndrome is caused by AMH gene mutation; type II syndrome is due to AMHR mutation.  (OMIM, Swiss-Prot, and NCI)
C21335	CD3-Epsilon-Associated_Protein	Protein_with_Unknown_or_Unclassified_Function	CD3-Epsilon-Associated Protein|ASE-1|Antisense to ERCC-1|CAST	The 3-prime terminus of human ERCC1, a DNA repair gene, overlaps the 3-prime end of Antisense to ERCC-1 Gene.  This exceptional type of overlap is conserved in mouse and even in yeast RAD10, an ERCC1 homolog, suggesting an important biologic function.  ASE1 appears to encode a 399-amino acid 43 kD ASE1 Protein.  (Swiss-Prot, OMIM, and NCI)
C21336	Arachidonate_15-Lipoxygenase	Oxygenase	Arachidonate 15-Lipoxygenase|15-LOX|15-Lipoxygenase, Reticulocyte Arachidonate|ALOX15|Arachidonate Omega-6 Lipoxygenase	Encoded by human ALOX15 Gene, a putative mutator gene regulated by tumor-suppressor TP53, 661-amino acid 74.7 kD cytoplasmic Arachidonate 15-Lipoxygenase (Lipoxygenase Family) acts in leukotriene biosynthesis and is implicated in anti-inflammation, membrane remodeling, and cancer development or metastasis.  It converts arachidonic acid to 15s-hydroperoxyeicosatetraenoic acid.  (OMIM, Swiss-Prot, and NCI)
C21337	ARMET_Protein	Protein_with_Unknown_or_Unclassified_Function	ARMET Protein|ARMET|Arginine-Rich Mutated in Early Stage Tumors|Arginine-Rich Protein	Encoded by human oncogene ARMET Gene, ARMET Protein is a highly conserved arginine-rich putative secreted product that belongs to the ARMET family.  (Swiss-Prot, OMIM, and NCI)
C21338	Arrestin_Beta_1_Protein	Retired_Concepts	Arrestin, Beta 1 Protein
C21339	AMSH_Protein	Signaling_Protein	AMSH Protein|AMSH|Associated Molecule with the SH3 Domain of STAM	Cytokine-mediated signal transduction in the JAK-STAT cascade requires the involvement of adaptor molecules. One such signal-transducing adaptor molecule contains an SH3 domain that is required for induction of MYC and cell growth. This protein binds to the SH3 domain of the signal-transducing adaptor molecule, and plays a critical role in cytokine-mediated signaling for MYC induction and cell cycle progression. (LocusLink)
C21340	RAS_Homolog_Gene_Family_Member-H_Protein	RAS_Superfamily_Protein	RAS Homolog Gene Family Member H Protein|ARHH|GTP-Binding Protein TTF|RHO-Related GTP-Binding Protein RHOH|RHOH/TTF Protein	Encoded by human oncogene ARHH Gene, the 191-amino acid 21 kD hemopoietic cell RHOH/TTF Protein contains residues associated with binding and hydrolysis of GTP.  ARHH belongs to the small GTPase superfamily, RHO family; highest identity is found with RHO-like CDC42 protein.  (OMIM, Swiss-Prot, and NCI)
C21341	Activated-p21cdc42Hs_Kinase	Protein_Tyrosine_Kinase	Activated p21cdc42Hs Kinase|ACK1|Activated CDC42 kinase 1	Activated p21cdc42Hs Kinase, encoded by the ACK1 gene, is a non-receptor tyrosine kinase. It binds CDC42 in its GTP-bound activated form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of CDC42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The encoded protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of CDC42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. (From LocusLink, OMIM and NCI)
C21342	Scanning_Transmission_Electron_Microscopy	Electron_Microscopy	Scanning Transmission Electron Microscopy|STEM	An electron microscopic technique for producing images of a surface by scanning an electron beam over the sample and measuring the electronic interactions at the interface. This technique provides highly magnified images of surface morphology. (NCI2005)
C21343	BMP10_Gene	Bone_Morphogenetic_Protein_Gene	BMP10 Gene|BMP10|Bone Morphogenetic Protein 10 Gene	Human BMP10 Gene (TGF-beta Family) encodes 424-aa 48-kD homodimeric secreted Bone Morphogenetic Protein 10, a putative growth factor that may signal through receptor serine/threonine kinases involved in trabeculation of the embryonic heart. (NCI)
C21344	Growth_Factor_Gene	Gene	Growth Factor Gene|Proto-Oncogene, Growth Factor	Genes that code for growth factors.
C21345	Transforming_Growth_Factor-Beta_Family_Gene	Growth_Factor_Gene	Transforming Growth Factor-Beta Family Gene	Expressed in a variety of tissues, Transforming Growth Factor-Beta Family Genes encode Transforming Growth Factor-Beta, an autocrine growth factor that can act synergistically with TGF-alpha in embryonic development, cellular differentiation, hormone secretion, and immune function. There are at least three forms of TGF-beta: TGF-beta 1, TGF-beta 2, and TGF-beta 1.2. The latter is a heterodimer of TGF-beta 1 and TGF-beta 2. (NCI)
C21346	Bone_Morphogenetic_Protein-10	Bone_Morphogenetic_Protein	Bone Morphogenetic Protein 10|BMP-10|BMP10	Encoded by human BMP10 Gene (TGF-beta Family), 424-aa 48-kD homodimeric secreted Bone Morphogenetic Protein 10 is a putative growth factor that may signal through receptor serine/threonine kinases involved in trabeculation of the embryonic heart. (NCI)
C21347	BMP15_Gene	Bone_Morphogenetic_Protein_Gene	BMP15 Gene|BMP15|GDF9B Gene|Growth Differentiation Factor 9B Gene|Mone Morphogenetic Protein 15 Gene	The BMP15 gene encodes a protein that is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9. Bone morphogenetic protein 15 signals through receptor serine/threonine kinases. The BMP15 gene is located at chromosome Xp11.2. (From LocusLink)
C21348	Bone_Morphogenetic_Protein-15	Bone_Morphogenetic_Protein	Bone Morphogenetic Protein 15|BMP-15|BMP15|GDF-9B|Growth/Differentiation Factor 9B	Bone Morphogenetic Protein 15 encoded by the BMP15 gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The transforming growth factor-beta superfamily includes large families of growth and differentiation factors. It is thought that this protein may be involved in oocyte maturation and follicular development as a homodimer or by forming heterodimers with a related protein, Gdf9. Bone morphogenetic protein 15 signals through receptor serine/threonine kinases. (From LocusLink)
C21349	BMP2_Gene	Bone_Morphogenetic_Protein_Gene	BMP2 Gene|BMP2|BMP2A Gene|Bone Morphogenetic Protein 2 Gene|Bone Morphogenetic Protein 2A Gene	The BMP2 gene encodes a protein that belongs to the transforming growth factor-beta (TGFB) superfamily. By signaling through receptor serine/threonine kinases, Bone morphogenic protein induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. The BMP2 gene is located at chromosome 20p12. (From LocusLink)
C21350	Bone_Morphogenetic_Protein-2	Bone_Morphogenetic_Protein	Bone Morphogenetic Protein 2|BMP-2|BMP-2A|BMP2	Bone Morphogenetic Protein 2, encoded by the BMP2 gene, is a protein that belongs to the transforming growth factor-beta (TGFB) superfamily. By signaling through receptor serine/threonine kinases, Bone morphogenic protein 2 induces bone formation. BMP2 is a candidate gene for the autosomal dominant disease of fibrodysplasia (myositis) ossificans progressiva. (From LocusLink)
C21351	BMP3_Gene	Bone_Morphogenetic_Protein_Gene	BMP3 Gene|BMP3|Bone Morphogenetic Protein 3 Gene	The BMP3 gene encodes a protein that belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein 3 induces bone formation by signaling through receptor serine/threonine kinases. It is expressed in lung, ovary and small intestine. The expression signals of BMP3 mRNA in malignant schwannoma are relatively lower than in benign lesions. The BMP3 gene is located at chromosome 4p14-q21. (From LocusLink)
C21352	Osteogenic_Bone_Morphogenetic_Protein-3	Bone_Morphogenetic_Protein	Bone Morphogenetic Protein 3|BMP-3|BMP-3A|BMP3|Bone Morphogenetic Protein 3 (Osteogenic)|Osteogenin	Bone Morphogenetic Protein 3 (Osteogenic), encoded by the BMP3 gene that belongs to the transforming growth factor-beta (TGFB) superfamily. Bone morphogenic protein 3 induces bone formation by signaling through receptor serine/threonine kinases. It is expressed in lung, ovary and small intestine. The expression signals of BMP3 mRNA in malignant schwannoma are relatively lower than in benign lesions. (From LocusLink, Swiss_Prot and NCI)
C21353	BMP5_Gene	Bone_Morphogenetic_Protein_Gene	BMP5 Gene|BMP5|Bone Morphogenetic Protein 5 Gene	The BMP5 gene at chromosome 6p12.1 encodes a protein that is a member of the TGF-beta family of growth factors. Morphogenetic Protein 5 signals through receptor serine/threonine kinases and induces cartilage and bone formation. It is expressed in the lungs and liver. The expression signals of BMP-5 mRNA in malignant schwannoma are relatively lower than in benign lesions. (From LocusLink, Swiss_Prot and NCI)
C21354	Bone_Morphogenetic_Protein-5	Bone_Morphogenetic_Protein	Bone Morphogenetic Protein 5|BMP-5|BMP5	Bone Morphogenetic Protein 5, encoded by the BMP5 gene, is a member of the TGF-beta family of growth factors. Morphogenetic Protein 5 signals through receptor serine/threonine kinases and induces cartilage and bone formation. It is expressed in the lungs and liver. (NCI)
C21355	BMP6_Gene	Bone_Morphogenetic_Protein_Gene	BMP6 Gene|BMP6|Bone Morphogenetic Protein 6 Gene|VG1-Related Sequence|VGR1 Gene	The BMP6 gene at chromosome 6p24-p23 encodes a protein that is a member of the TGF-beta family. Bone morphogenetic protein 6 has strong similarity to murine Bmp6, signals through receptor serine/threonine kinases, and is involved in endochondral bone formation. (From LocusLink)
C21356	Bone_Morphogenetic_Protein-6	Bone_Morphogenetic_Protein	Bone Morphogenetic Protein 6|BMP6	Bone morphogenetic protein 6, encoded by the BMP6 gene, is a member of the TGF-beta family. It has strong similarity to murine Bmp6, signals through receptor serine/threonine kinases, and is involved in endochondral bone formation. (From LocusLink)
C21357	BMP7_Gene	Bone_Morphogenetic_Protein_Gene	BMP7 Gene|BMP7|Bone Morphogenetic Protein 7 Gene|OP1 Gene|Osteogenic Protein 1 Gene	The BMP7 gene at chromosome 20q13 encodes a protein that is a member of the TGF-beta family. Bone morphogenetic protein 7 signals through receptor serine/threonine kinases and has very strong similarity to murine Bmp7. At all anatomical sites disrupted by Holt-Oram syndrome mutations, BMP7 is expressed in all structures that are altered in Holt-Oram Syndrome patients, including the heart, proximal and distal forelimb, clavicle, and scapula, as well as other unaffected tissues. BMP7 is also expressed in the neural retina, lens, and developing cornea. (From LocusLink)
C21358	Bone_Morphogenetic_Protein-7	Bone_Morphogenetic_Protein	Bone Morphogenetic Protein 7|BMP-7|BMP7|OP-1|Osteogenic Protein 1	Bone Morphogenetic Protein 7 (BMP7), encoded by the BMP7 gene, is a member of the TGF-beta family. BMP7 signals through receptor serine/threonine kinases and has very strong similarity to murine Bmp7. BMP7 plays a role in calcium regulation and bone homeostasis. It induces cartilage and bone formation and may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. BMP7 is expressed in the kidney and bladder and lower levels are seen in the brain. At all anatomical sites disrupted by Holt-Oram syndrome mutations, BMP7 is expressed in all structures that are altered in Holt-Oram Syndrome patients, including the heart, proximal and distal forelimb, clavicle, and scapula, as well as other unaffected tissues. (NCI)
C21359	BMP8_Gene	Bone_Morphogenetic_Protein_Gene	BMP8 Gene|BMP8|Bone Morphogenetic Protein 8 Gene|OP-2|OP2|Osteogenic Protein 2 Gene	The BMP8 gene encodes a protein that is a member of the TGF-beta family of growth factors. Bone morphogenetic protein 8 signals through receptor serine/threonine kinases and plays a role in Bone Development and Maintenance. (From OMIM and NCI)
C21360	Bone_Morphogenetic_Protein-8	Bone_Morphogenetic_Protein	Bone Morphogenetic Protein 8|BMP-8|BMP8|OP-2|OP2|Osteogenic Protein 2	Bone morphogenetic protein 8 (BMP8), encoded by the BMP8 gene, is a member of the TGF-beta family of growth factors and signals through receptor serine/threonine kinases. BMP8 plays a role in calcium regulation and bone homeostasis. It induces cartilage and bone formation and may be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. (NCI)
C21361	CD2_Gene	Cell_Adhesion_Molecule_Gene	CD2 Gene|CD2|CD2 Antigen (p50), Sheep Red Blood Cell Receptor Gene|SRBC|T11	The 12-kb 5-exon human CD2 Gene encodes 351-aa 39.5-kDa (precursor) type I transmembrane glycoprotein T-Cell Surface Antigen CD2, containing an IgV domain, an IgC2 domain, and a proline-rich basic cytoplasmic domain implicated in signaling in T-cell triggering. The domain involved in cell adhesion is encoded by a single exon. LFA3/CD58 and CD48/BCM1 interaction with CD2 mediates adhesion between T cells and other cells. CD2 interaction with LFA3 on opposing cells optimizes immune recognition and facilitates helper T lymphocyte contact with antigen-presenting cells. CD2 may interact with CD2AP. (NCI)
C21362	CD4_Gene	Cell_Adhesion_Molecule_Gene	CD4 Gene|CD4|CD4 Antigen (P55) Gene|T-Cell Antigen T4/LEU3 Gene|T-cell surface antigen T4/Leu-3 Gene	The CD4 gene at 12pter-p12 encodes CD4 Antigen (P55), which is a T-cell surface glycoprotein. CD4 has a role in cell-cell interactions and may act in signal transduction. CD4 is a accessory protein for MHC class-II antigen/T-cell receptor interaction and functions to initiate or augment the early phase of T-cell activation. CD4 enhances T-cell sensitivity to antigen and binds to LCK, which phosphorylates CD3-zeta. (From LocusLink, OMIM and NCI)
C21363	CD80_Gene	Cell_Adhesion_Molecule_Gene	CD80 Gene|B7|B7-1|BB1|CD28LG|CD28LG1|CD80|CD80 Antigen (CD28 Antigen Ligand 1, B7-1 Antigen) Gene|LAB7	A molecule that helps control immune responses in the body.  B7-1 is involved in stimulating T-cells.
C21364	Receptor_Serine-Threonine_Kinase_Gene	Receptor_Gene	Receptor Serine/Threonine Kinase Gene	Receptor Serine/Threonine Kinase Genes encode receptor proteins that each bind to specific signaling factors causing a conformational and functional change in the ligand-bound receptor, altering its interaction with target molecules, increasing the receptor kinase activity, and leading to changes in cellular physiology through modification of the activity of one or more signal transduction pathways.
C21365	Bone_Morphogenetic_Protein_Receptor_Gene	Receptor_Serine-Threonine_Kinase_Gene	Bone Morphogenetic Protein Receptor Gene	Bone Morphogenetic Protein Receptor Genes encode Bone Morphogenetic Protein Receptors, activated by Bone Morphogenetic Proteins, non-collagenous bone-growth regulatory factors synthesized as large precursor molecules that are cleaved by proteolytic enzymes and form an active homodimer or heterodimer of two related bone morphogenetic proteins that stimulate osteogenesis. (NCI)
C21366	BMPR1A_Gene	Bone_Morphogenetic_Protein_Receptor_Gene	BMPR1A Gene|ACVRLK3 Gene|BMPR1A|Bone Morphogenetic Protein Receptor, Type IA Gene	This gene encodes for a type I bone morphogenetic protein (BMP) receptor that is a transmembrane serine/threonine kinase. Germline mutations in BMPR1A cause a subset of juvenile polyposis syndrome and Cowden syndrome. (From LocusLink)
C21367	Bone_Morphogenetic_Protein_Receptor_Type-IA	Receptor_Serine-Threonine_Kinase	Bone Morphogenetic Protein Receptor, Type IA|BMPR1A	The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Germline mutations in BMPR1A cause a subset of juvenile polyposis syndrome and Cowden syndrome. (From LocusLink)
C21368	BMPR2_Gene	Bone_Morphogenetic_Protein_Receptor_Gene	BMPR2 Gene|BMPR2|Bone Morphogenetic Protein Receptor, Type II (Serine/Threonine Kinase) Gene	The BMPR2 gene at chromosome 2q33-q34 encodes a member of the bone morphogenetic protein (BMP) receptor family of transmembrane serine/threonine kinases. The ligands of this type II receptor are BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. These proteins transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. This gene expresses two transcript variants.
C21369	Bone_Morphogenetic_Protein_Receptor_Type-II	Receptor_Serine-Threonine_Kinase	Bone Morphogenetic Protein Receptor Type II|BMPR2|Bone Morphogenetic Protein Receptor, Type II (Serine/Threonine Kinase)	Encoded by human BMPR2 Gene (BMP Receptor Family), Bone Morphogenetic Protein Receptor Type II is a type II transmembrane serine/threonine kinase receptor for BMPs, which are members of the TGF-beta superfamily. BMPs are involved in endochondral bone formation and embryogenesis. BMP receptors transduce their signals through the formation of heteromeric complexes of 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling; type I receptors require their respective type II receptors for ligand binding. Mutations in this gene have been associated with primary pulmonary hypertension. (NCI)
C21370	BMX_Gene	Non-Receptor_Tyrosine_Kinase_Gene	BMX Gene|BMX|BMX Non-Receptor Tyrosine Kinase Gene|ETK Gene|PSCTK2 Gene|PSCTK3 Gene	Tyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC, TXK, ITK, and BTK. All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain. The BMX gene at chromosome Xp22.2 encodes an 80-kD protein that is a nonreceptor tyrosine kinase. BMX may play a role in the growth and differentiation of hematopoietic cells. BMX is transcribed and translated in bone marrow as well as human endothelial cells. There is no obvious phenotype with loss of BMX function, suggesting that this tyrosine kinase has a redundant role in arterial endothelial signal transduction. (From OMIM)
C21371	CD8B1_Gene	Cell_Adhesion_Molecule_Gene	CD8B1 Gene|CD8|CD8 Antigen, Beta Polypeptide 1 (p37) Gene|CD8B|CD8B1|LYT3	The CD8B1 gene encodes CD8 Antigen, Beta Polypeptide 1, which is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. This protein, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigen displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. Six alternative transcripts encoding different isoforms, four membrane associated and two secreted, have been identified. A pseudogene, also located on chromosome 2, has been identified. (from LocusLink)
C21372	BMX_Non-Receptor_Tyrosine_Kinase	Protein_Tyrosine_Kinase	BMX Non-Receptor Tyrosine Kinase|BMX|Bone Marrow Kinase BMX|ETK|Epithelial and Endothelial Tyrosine Kinase|NTK38|PSCTK2|PSCTK3	Expressed in bone marrow and endothelia by human BMX Gene, intracellular 80-kD BMX Non-Receptor Tyrosine Kinase is a member of the non-receptor tyrosine kinase family (contain an SH3 and SH2 domain upstream of the TK domain) that includes TEC, TXK, ITK, and BTK; homologs of Src28 TK (Drosophila). BMX may play a role in growth and differentiation of hematopoietic cells. There is no obvious phenotype associated with loss of BMX function, suggesting that this tyrosine kinase has a redundant role in arterial endothelial signal transduction. (NCI)
C21373	BNIP3L_Gene	Apoptosis_Promoter_Gene	BNIP3L Gene|Adenovirus E1b19k-Binding Protein B5 Gene|BCL2/Adenovirus E1B 19-Kd Protein-Interacting Protein 3a Gene|BCL2/Adenovirus E1B 19kd Interacting Protein 3-Like Gene|BNIP3A Gene|BNIP3L|NIX Gene	This gene at chromosome 8p21 encodes a member of the BCL2/adenovirus E1B 19 kD-interacting protein (BNIP) family. It promotes apoptosis by interacting with the antiapoptotic E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as cellular Bcl2 and Bcl2L1, also an apoptotic protector. This protein is a functional homolog of BNIP3, a proapoptotic protein, and may function simultaneously with BNIP3. It may play a role in tumor suppression. (From LocusLink)
C21374	Adenovirus_E1b19kD-Binding_Protein-B5	Apoptosis_Promoter	BCL2/Adenovirus E1B 19kd Interacting Protein 3-Like|Adenovirus E1b19k-Binding Protein B5|BCL2/Adenovirus E1B 19-Kd Protein-Interacting Protein 3a|BNIP3L|BNIP3a|NIX	BCL2/Adenovirus E1B 19kd Interacting Protein 3-Like, encoded by the BNIP3L gene, is a member of the BCL2/adenovirus E1B 19 kD-interacting protein (BNIP) family. It promotes apoptosis by interacting with the antiapoptotic E1B 19 kDa protein which is responsible for the protection of virally-induced cell death, as well as cellular antiapoptotic proteins Bcl2 and Bcl2L1. It can overcome the suppressor bcl-2 and bcl-xl, although high levels of bcl-xl expression will inhibit apoptosis. This protein is a functional homolog of BNIP3, a proapoptotic protein, and may function simultaneously with BNIP3. It may play a role in tumor suppression. (From LocusLink)
C21375	BRD2_Gene	Signaling_Pathway_Gene	BRD2 Gene|BRD2|Bromodomain Containing 2 Gene|D6S113E|FSRG1|Female Sterile Homeotic-Related Gene 1|KIAA9001|NAT|RING3|RNF3	This gene encodes a mitogen-activated kinase which localizes to the nucleus. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3 but sequence comparison suggests that the protein is not involved in the immune response. Homology to the Drosophila gene female sterile homeotic suggests that this human gene may be part of a signal transduction pathway involved in growth control. (LocusLink)
C21376	Bromodomain_Containing_Protein-2	Mitogen-Activated_Protein_Kinase	Bromodomain Containing Protein 2|BRD2	Bromodomain Containing Protein 2, encoded by the BRD2 gene is a mitogen-activated kinase which localizes to the nucleus. Homologous to the Drosophila gene female sterile homeotic, Bromodomain Containing Protein 2 may be part of a signal transduction pathway involved in growth control and may function in spermatogenesis. This protein contains 2 bromodomain and 1 ET domain but is not involved in the immune response. (From LocusLink)
C21377	BRDG1_Gene	Signaling_Pathway_Gene	BRDG1 Gene|BCR Downstream Signaling 1 Gene|BRDG1	The BRDG1 gene at chromosome 4q13.1 encodes BCR Downstream Signaling 1, a docking protein that acts downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The encoded protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart. It has a proline-rich region, a pleckstrin homology domain and SH2 domain. (From LocusLink)
C21378	BCR_Downstream_Signaling-1_Protein	Signaling_Protein	BCR Downstream Signaling 1|BRDG1|Docking protein BRDG1|STAP-1	BCR Downstream Signaling 1, encoded by BRDG1 gene, functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. This protein is directly phosphorylated by Tec in vitro where it participates in a positive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart. It has a proline-rich region, a pleckstrin homology domain and SH2 domain. (From LocusLink, Swiss_Prot and NCI)
C21379	BTG2_Gene	Cell_Cycle_Gene	BTG2 Gene|B-Cell Translocation Gene 1, Anti-Proliferative|BTG Family, Member 2 Gene|BTG2|PC3	The BTG1 gene at chromosome 12q22 is a member of a family of antiproliferative genes. It negatively regulates cell proliferation and has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The BTG protein is degraded by the ubiquitin-proteasome system and the C-terminal region is necessary and sufficient to control its stability. (From LocusLink)
C21380	BTG2_Protein	Cell_Cycle_Protein	BTG2 Protein|B-Cell Translocation Gene 2 Protein|BTG Family, Member 2|BTG2|NGF-Inducible Anti-Proliferative Protein PC3	B-Cell Translocation Protein 1, encoded by the BTG1 gene, is a member of a family of antiproliferative proteins. It negatively regulates cell proliferation. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The BTG protein is degraded by the ubiquitin-proteasome system and the C-terminal region is necessary and sufficient to control its stability. (From LocusLink)
C21381	ADRBK1_Gene	Serine-Threonine_Protein_Kinase_Gene	ADRBK1 Gene|ADRBK1|Adrenergic, Beta, Receptor Kinase 1 Gene|BARK|BARK1|Beta-ARK-1|GRK2	The ADRBK1 gene at chromosome 11q13 encodes beta-adrenergic receptor kinase (ADRBK1), which phosphorylates the beta-2-adrenergic receptor and mediates agonist-specific desensitization observed at high agonist concentrations. ADRBK1, an ubiquitous cytosolic enzyme, translocates from the cytosol to the plasma membrane upon agonist stimulation and specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by ADRBK1, an enzyme known to be elevated in failing human heart tissue. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. Inhibition of ADRBK1 is a novel mode of therapy. (From LocusLink)
C21382	Beta_Adrenergic_Receptor_Kinase-1	Serine-Threonine_Protein_Kinase	Beta-Adrenergic Receptor Kinase 1|ADRBK1|BARK1|BETA-ARK1|Beta-ARK-1|EC 2.7.1.126|G-Protein Coupled Receptor Kinase 2|GRK2	Beta-adrenergic receptor kinase 1 (ADRBK1), encoded by the ADRBK1 gene, phosphorylates the beta-2-adrenergic receptor and mediates agonist-specific desensitization observed at high agonist concentrations. ADRBK1, an ubiquitous cytosolic enzyme, translocates from the cytosol to the plasma membrane upon agonist stimulation and specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Heart failure is accompanied by severely impaired beta-adrenergic receptor (beta-AR) function. An important mechanism for the rapid desensitization of beta-AR function is agonist-stimulated receptor phosphorylation by ADRBK1, an enzyme known to be elevated in failing human heart tissue. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. Inhibition of ADRBK1 is a novel mode of therapy. (From LocusLink)
C21383	ADRBK2_Gene	Serine-Threonine_Protein_Kinase_Gene	ADRBK2 Gene|ADRBK2|Adrenergic, Beta, Receptor Kinase 2 Gene|BARK2|Beta-ARK-2|GRK3	The ADRBK2 gene at chromosome 22q12.1 encodes Adrenergic, Beta, Receptor Kinase 2 (ADRBK2), which specifically phosphorylates the agonist-occupied and -activated form of the beta-adrenergic and related G protein-coupled receptors. ADRBK2 regulates desensitization of G protein-coupled receptors. Overall, the ADRBK2 enzyme has 85% amino acid similarity with ADRBK1, with the protein kinase catalytic domain having 95% similarity. The ADRBK2 mRNA is approximately 8 kilobases with a distribution similar to that of ADRBK1. (From LocusLink)
C21384	Beta_Adrenergic_Receptor_Kinase-2	Serine-Threonine_Protein_Kinase	Beta-Adrenergic Receptor Kinase 2|ADRBK2|BARK2|Beta Adrenergic Receptor Kinase 2|Beta-ARK-2|EC 2.7.1.126|G-Protein Coupled Receptor Kinase 3|GRK3	Adrenergic, Beta, Receptor Kinase 2 (ADRBK2), encoded by the ADRBK2 gene, specifically phosphorylates the agonist-occupied and -activated form of the beta-adrenergic and related G protein-coupled receptors. ADRBK2 regulates desensitization of G protein-coupled receptors. Overall, the ADRBK2 enzyme has 85% amino acid similarity with ADRBK1, with the protein kinase Catalytic Domain Having 95% Similarity. (From Locuslink)
C21385	AF5Q31_Gene	Transcription_Factor_Gene	AF5Q31 Gene|AF5Q31|ALL1 Fused Gene From 5q31 Gene	The AF5q31 gene at chromosome 5q31 encodes a transcription factor. It is expressed in fetal heart, lung, and brain at relatively high levels and in fetal liver at a low level, but the expression in these tissues is decreased in adults. The AF5q31 protein is homologous to AF4-related proteins, including AF4, LAF4, and FMR2. The AF5q31 and AF4 proteins have 3 homologous regions, including the transactivation domain of AF4. Infantile acute lymphoblastic leukemia (ALL) with rearrangements of the MLL gene is characterized by early pre-B phenotype and poor treatment outcome. The AF5Q31 gene is a fusion partner of the MLL gene involved in the pathogenesis of 11q23-associated ALL. (From LocusLink and OMIM)
C21386	AF5Q31_Protein	Transcription_Factor	ALL1 Fused Gene From 5q31|AF5Q31|ALL1 Fused Gene From Chromosome 5q31	ALL1 Fused Gene From 5q31, a protein encoded by the AF5q31 gene, is a transcription factor. It is expressed in fetal heart, lung, and brain at relatively high levels and in fetal liver at a low level, but the expression in these tissues is decreased in adults. The AF5q31 protein is homologous to AF4-related proteins, including AF4, LAF4, and FMR2. The AF5q31 and AF4 proteins have 3 homologous regions, including the transactivation domain of AF4. Infantile acute lymphoblastic leukemia (ALL) with rearrangements of the MLL gene is characterized by early pre-B phenotype and poor treatment outcome. The AF5Q31 gene is a fusion partner of the MLL gene involved in the pathogenesis of 11q23-associated ALL. (From LocusLink and OMIM)
C21387	AGTR2_Gene	G_Protein-Coupled_Receptor_Gene	AGTR2 Gene|AGTR2|AT2|Angiotensin II Receptor, Type 2 Gene	The AGTR2 gene at chromosome Xq22-q23 encodes Angiotensin Receptor 2, which is an integral membrane protein and a member of G-protein coupled receptor family. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. The human AGTR2 gene is composed of three exons and spans at least 5 kb. Exons 1 and 2 encode for 5' untranslated mRNA sequence and exon 3 harbors the entire uninterrupted open reading frame. (From LocusLink)
C21388	Angiotensin_Receptor-2	G_Protein-Coupled_Receptor	Angiotensin Receptor 2|AGTR2|AT2|Angiotensin II Receptor, Type 2|Type-2 Angiotensin II Receptor	Angiotensin Receptor 2, encoded by the AGTR2 gene, is an integral membrane protein and a member of G-protein coupled receptor family. It plays a role in the central nervous system and cardiovascular functions that are mediated by the renin-angiotensin system. This receptor mediates programmed cell death (apoptosis). In adults, it is highly expressed in myometrium with lower levels in adrenal gland and fallopian tube. It is highly expressed in fetal kidney and intestine. (From LocusLink)
C21389	AIM1_Gene	Gene_with_Unknown_or_Unclassified_Function	AIM1 Gene|AIM1|Absent In Melanoma 1 Gene|Absent in Melanoma 1|ST4	Based upon sequence analysis the AIM1 protein appears to be a member of the beta-gamma crystallin superfamily.  However, it is the first mammalian member of the family with a primarily non-lens role.  Other parts of the predicted AIM1 protein sequence have weak similarity with filament or actin-binding proteins. The authors suggested that AIM1 is a good candidate for the putative suppressor of malignant melanoma on chromosome 6 (Trent et al., 1990), possibly exerting its effects through interactions with the cytoskeleton. (from OMIM)
C21390	Absent_in_Melanoma_1_Protein	Protein_with_Unknown_or_Unclassified_Function	Absent in Melanoma 1|AIM1|ST4|ST4 Protein	Based upon sequence analysis the AIM1 protein appears to be a member of the beta-gamma crystallin superfamily.  However, it is the first mammalian member of the family with a primarily non-lens role.  Other parts of the predicted AIM1 protein sequence have weak similarity with filament or actin-binding proteins. The authors suggested that AIM1 is a good candidate for the putative suppressor of malignant melanoma on chromosome 6 (Trent et al., 1990), possibly exerting its effects through interactions with the cytoskeleton. (from OMIM)
C21391	AIM2_Gene	Gene_with_Unknown_or_Unclassified_Function	AIM2 Gene|AIM2|Absent In Melanoma 2 Gene|Absent in Melanoma 2	The AIM2 gene at chromosome 1q22 encodes a protein that is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. (From LocusLink)
C21392	Absent_in_Melanoma_2_Protein	Protein_with_Unknown_or_Unclassified_Function	Absent in Melanoma 2|AIM2|Interferon-Inducible Protein AIM2	Absent In Melanoma 2, a protein encoded by the AIM2 gene, is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. (From LocusLink)
C21393	RNR1_Gene	Ribosome_Subunit_Gene	RNR1 Gene|RNA, Ribosomal 1 Gene|RNR1	RNR1 gene at 13q12 is one of the rRNA genes encoding for ribosomal RNA (rRNA). At the ribosomal RNA gene promoter, transcription initiation by RNA polymerase I allows synthesis of the 45S rRNA precursor molecule, which serves as the molecular precursor for the 18S, 5S and 28S ribosomal RNA components. These mature rRNA molecules associated with other proteins are the structural components of a ribosome. The ribosome, composed of large and small units, is the factory where the polypeptides are produced by interacting with tRNA and mRNA. (From OMIM)
C21394	RPL8_Gene	Ribosome_Subunit_Gene	RPL8 Gene|RPL8|Ribosomal Protein L8 Gene	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. The RPL8 gene at chromosome 8q24.3 encodes Ribosomal Protein L8, a ribosomal protein that is a component of the 60S subunit. This protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (From LocusLink)
C21395	Ribosomal_Protein-L8	Ribosomal_Protein	Ribosomal Protein L8|60S Ribosomal Protein L8|RPL8	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. Ribosomal Protein L8, encoded by the RPL8 gene is a ribosomal protein that is a component of the 60S subunit. This protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (From LocusLink)
C21396	RPL19_Gene	Ribosome_Subunit_Gene	RPL19 Gene|RPL19|Ribosomal Protein L19 Gene	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. The RPL19 gene at chromosome 17q11.2-q12 encodes a ribosomal protein that is a component of the large 60S ribosomal subunit. This protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (From LocusLink)
C21397	Ribosomal_Protein-L19	Ribosomal_Protein	Ribosomal Protein L19|60S Ribosomal pProtein L19|RPL19	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. Ribosomal Protein L19, encoded by the RPL19 gene is a ribosomal protein that is a component of the 60S subunit. This protein belongs to the L2P family of ribosomal proteins. It is located in the cytoplasm. Alternatively spliced transcript variants encoding the same protein exist. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (From LocusLink)
C21398	RPL29_Gene	Ribosome_Subunit_Gene	RPL29 Gene|RPL29|Ribosomal Protein L29 Gene	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. The RPL29 gene at chromosome 3p21.3-p21.2 encodes a ribosomal protein that is a component of the large 60S ribosomal subunit. This protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin/heparan sulfate. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. (From LocusLink)
C21399	Ribosomal_Protein-L29	Ribosomal_Protein	Ribosomal Protein L29|60S Ribosomal Protein L29|Cell Surface Heparin-Binding Protein HIP|HIP|HP/HS-Interacting Protein|HUMRPL29|Heparin/Heparan Sulfate-Binding Protein|Heparin/Heparan Sulfate-Interacting Protein|RPL29	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. Ribosomal Protein L29, encoded by the RPL29 gene, is a ribosomal protein that is a component of the large 60S ribosomal subunit. This protein belongs to the L19E family of ribosomal proteins. It is located in the cytoplasm. The protein is also a peripheral membrane protein expressed on the cell surface that directly binds heparin/heparan sulfate. (From LocusLink)
C21400	CTBP1_Gene	Transcription_Corepressor_Gene	CTBP1 Gene|C-Terminal Binding Protein 1 Gene|CTBP1	The CTBP1 gene at chromosome 4p16 encodes the phosphoprotein C-Terminal Binding Protein 1 (CTBP-1), which is a transcriptional repressor targeting diverse transcription regulators. CTBP1 binds the C-terminus of adenovirus E1A protein. It also interacts with ELK3 and CTIP via their consensus motif. CTBP1 may play a role during cellular proliferation, adenovirus replication and oncogenic transformation. The level of phosphorylation may be regulated during the cell cycle. CTBP1 can form homodimers or heterodimers of CTBP1 and CTBP2. (From LocusLink, Swiss_Prot)
C21401	C-Terminal_Binding_Protein-1	Transcription_Repressor_Corepressor	C-Terminal Binding Protein 1|CTBP1	The phosphoprotein C-Terminal Binding Protein 1 (CTBP-1), encoded by the CTBP1 gene, is a transcriptional repressor targeting diverse transcription regulators. CTBP1 binds the C-terminus of adenovirus E1A protein. It also interacts with ELK3 and CTIP via their consensus motif. CTBP1 may play a role during cellular proliferation, adenovirus replication and oncogenic transformation. The level of phosphorylation may be regulated during the cell cycle.CTBP1 can form homodimers or heterodimers of CTBP1 and CTBP2. (From LocusLink, Swiss_Prot)
C21402	MSH4_Gene	DNA_Repair_Gene	MSH4 Gene|MSH4|MutS Homolog 4 (E. coli) Gene	The MSH4 gene at chromosome 1p31 encodes MutS Homolog 4, a 105-kD protein that belongs to the DNA mismatch repair muts family and is involved in meiotic recombination. It is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. The human MSH4 transcripts are detectable only in testis and in ovary with a lower level of expression. (From LocusLink, OMIM, Swiss_Prot)
C21403	MutS_Homolog-4_Protein	DNA_Repair_Protein	MutS Homolog 4|MSH4|MutS (E. coli) Homolog 4	MutS Homolog 4, a 105-kD protein encoded by the MSH4 gene, belongs to the DNA mismatch repair muts family and is involved in meiotic recombination. It is required for reciprocal recombination and proper segregation of homologous chromosomes at meiosis. The human MSH4 transcripts are detectable only in testis and in ovary with a lower level of expression. (From LocusLink, OMOM, Swiss_Prot)
C21406	SPO11_Gene	Ligand_Binding_Protein_Gene	SPO11 Gene|SPO11|SPO11 Meiotic Protein Covalently Bound to DSB-Like (S. Cerevisiae) Gene	The Spo11 gene at chromosome 20q13.2-q13.3 encodes SPO11 Meiotic Protein Covalently Bound to DSB-Like (SPO11), a protein that belongs to the TOP6A family. Meiotic recombination and proper segregation of chromosomes are initiated by the formation of double-strand breaks (DSBs) in paired homologs. Located in the nucleus, SPO11 is required for meiotic DSB formation and is covalently linked to the 5-prime end of DSBs during meiosis. SPO11 mediates DNA cleavage with assistance from a large number of other gene products, by a topoisomerase-like transesterase mechanism. SPO11 is highly expressed in testis. Two isoforms, 1 and 2, may be produced by alternative splicing. (From Swiss_Prot, OMIM)
C21408	VEGF_Gene	Growth_Factor_Gene	VEGF Gene|VEGF|VEGFA|Vascular Endothelial Growth Factor Gene	The VEGF Gene (PDGF/VEGF Family) at 6p12 encodes seven alternatively spliced isoforms of Vascular Endothelial Growth Factor: VEGF206, VEGF189, VEGF183, VEGF165/VEGF, VEGF148, VEGF145, and VEGF121. This gene is regulated by growth factors, cytokines, gonadotropins, nitric oxide, hypoxia, and hypoglycemia. Expression is induced by hypoxia and E2 regulates transcription through a variant upstream ERE. VEGF is a disulfide-linked, 41-45 kD secreted homodimeric glycoprotein that may also heterodimerize with PLGF. VEGF induces endothelial cell proliferation, promotes cell migration, induces vascular permeabilization, and inhibits apoptosis. Neuropilin-1 (VEGF165R), a collapsin/semaphorin receptor that mediates neuronal cell guidance, binds VEGF165 and VEGF145, but not VEGF121. Neuropilin-1 enhances VEGF165 binding to KDR and VEGF165-mediated chemotaxis.  (OMIM, Swiss-Prot, LocusLink and NCI)
C21409	SPO11_Homolog_Protein	DNA_Binding_Protein	SPO11 Meiotic Protein Covalently Bound to DSB-Like|SPO11|SPO11 Protein Homolog	SPO11 Meiotic Protein Covalently Bound to DSB-Like (SPO11), a protein encoded by the Spo11 gene, belongs to the TOP6A family. Meiotic recombination and proper segregation of chromosomes are initiated by the formation of double-strand breaks (DSBs) in paired homologs. Located in the nucleus, SPO11 is required for meiotic DSB formation and is covalently linked to the 5-prime end of DSBs during meiosis. SPO11 mediates DNA cleavage with assistance from a large number of other proteins, by a topoisomerase-like transesterase mechanism. SPO11 is highly expressed in testis. Two isoforms, 1 and 2, may be produced by alternative splicing. (NCI)
C21410	VEGFC_Gene	Growth_Factor_Gene	VEGFC Gene|VEGFC|VRP Gene|Vascular Endothelial Growth Factor C Gene	The VEGFC Gene (PDGF/VEGF Family) at 4q34.1-q34.3 encodes Vascular Endothelial Growth Factor C, which may maintain the adult lymphatic endothelium. VEGFC is active in angiogenesis, endothelial cell growth, and blood vessel permeability. It is a high affinity FLT4 ligand and a 23 kD disulfide-linked homodimeric secreted protein that is homologous to VEGF and VEGFB/VRF. The C-terminus has cysteine-rich BR3P repeats. VEGFC can activate lymphatic endothelial VEGFR3 (FLT4) and endothelial cell VEGFR2 (KDR/FLK1) receptor tyrosine kinases. VEGFC undergoes complex proteolytic maturation to generate isoforms with increased activity toward VEGFR3 but only the fully processed form activates VEGFR2. Mature VEGFC is composed mostly of two VEGF homology domains bound by non-covalent interactions. (OMIM, Swiss-Prot, LocusLink and NCI)
C21411	VIP_Gene	Peptide_Hormone_Gene	VIP Gene|VIP|Vasoactive Intestinal Peptide Gene	Human oncogene VIP Gene (Glucagon-Secretin Family) at 6q26-q27 encodes Vasoactive Intestinal Peptide, an octacosameric gastrointestinal peptide and a neuroendocrine mediator in CNS cholinergic neurons and PNS peptidergic neurons. VIP also affects B- and T cells directly. The 20 Dalton primary translation product (prepro-VIP) contains VIP and 27-amino acid PHM27; VIP and PHM-27 are encoded by adjacent exons. A neuropeptide in the lymphoid microenvironment, VIP has anti-inflammatory action, modulates innate and adaptive immunity, causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis, and relaxes the smooth muscle of trachea, stomach and gall bladder. VIP promotes TH2 differentiation and inhibits TH1 responses by regulating macrophage co-stimulatory signals.  (Omim, Swiss-Prot, LocusLink, and NCI)
C21412	CCNE1_Gene	Cyclin_Gene	CCNE1 Gene|CCNE|CCNE1|CGE1|Cyclin E1 Gene	The CCNE1 gene at chromosome 19q12 encodes Cyclin E1, a protein that forms a complex with, and functions as a regulatory subunit of CDK2, whose activity is required for cell cycle G1/S transition. Cyclin E1 accumulates at the G1-S phase boundary and phosphorylation by CDK2 triggers its release from CDK2 and degradation. Overexpression of this gene is observed in many tumors, which results in chromosome instability and may contribute to tumorigenesis. Cyclin E1 is associated with and involved in the phosphorylation of NPAT protein (nuclear protein mapped to the ATM locus), which participates in cell-cycle regulated histone gene expression and plays a critical role in promoting cell-cycle progression in the absence of pRB. Two isoforms, E1L and E1S, are produced by alternative splicing and E1S cannot complex with CDK2. Cyclin E1 is highly expressed in testis and placenta with low levels in bronchial epithelial cells. (NCI)
C21413	VIPR1_Gene	G_Protein-Coupled_Receptor_Gene	VIPR1 Gene|RDC1 Gene|VIPR Gene|VIPR1|Vasoactive Intestinal Peptide Receptor 1 Gene	Human VIPR1 Gene (GPCR Family 2) at 3p22 encodes Vasoactive Intestinal Peptide Receptor 1. Spanning nearly 22 kb and comprised of thirteen exons (42-1,400 bp long) and twelve introns (0.3-6.1 kb long), VIPR1 generates long and short isoforms by alternative splicing. VIPR1 appears to be expressed in brain, heart, kidney, liver, colonic epithelia, and placenta. The VIP receptor appears to consist of 460 amino acids with 7 transmembrane domains. Distinct subsets of neural, respiratory, gastrointestinal, and immune cells bear high-affinity VIP G protein receptors, capable of activating adenylate cyclase.  (Omim, Swiss-Prot, LocusLink, and NCI)
C21414	Cyclin-E1	Cyclin	Cyclin E1|CCNE1|Cyclin E|Cyclin Es|Cyclin Et	Cyclin E may function at (cell cycle) START by interacting with CDC28.  Cyclin E complexes with CDK2 in late G1.  Cyclin-dependent kinase activation requires association with cyclins and phosphorylation by CAK, which leads to cell proliferation.  Association of CDK inhibitor with a cyclin/CDK complex inhibits proliferation. CCNE1/CDK2 promotes CDKN1B phosphorylation, elimination of CDKN1B, and G1/S progression of the cell cycle.  Enhanced CDKN1B inhibitory function arrests proliferation.  Cyclin E is bound directly by AGO, which probably targets its ubiquitin-mediated degradation.  (from OMIM 123837 and NCI)
C21415	APEX_Nuclease	Class-II_AP-Endonuclease	APEX Nuclease|AP Endonuclease Class I|AP Lyase|APE|APE1|APEN|APEX|APEX Nuclease (Multifunctional DNA Repair Enzyme)|APEX1|APX|Apurinic/Apyrimidinic (Abasic) Endonuclease|Apurinic/Apyrimidinic Exonuclease|DNA-(Apurinic or Apyrimidinic site) Lyase|Deoxyribonuclease (Apurinic or Apyrimidinic)|HAP1|Multifunctional DNA Repair Enzyme|REF-1|REF1	APEX Nuclease, encoded by the APE1 gene, is a ubiquitous monomeric apurinic/apyrimidinic DNA repair endonuclease (AP/EXOA family) with 3-prime-, 5-prime-exonuclease, DNA 3-prime repair diesterase, and DNA 3-prime-phosphatase activities. The constitutive gene contains five exons spanning 2.64 kb; the first exon is untranslated. The 0.5 kb upstream DNA contains only a possible CCAAT box and no other regulatory sites or a TATA box. A potent activator of p53 protein, APE1 may protect against cell lethality and suppress mutations produced by spontaneous hydrolysis, by chemicals and radiation, or by DNA glycosylases that remove abnormal bases from DNA. Abasic sites that can block DNA replication and cause mutations must be corrected to restore genetic integrity. A repressor of the PTH gene, APE binds to promoter negative Ca(2+)-response elements, which are also present in the APE1 gene. (NCI)
C21416	WHSC1_Gene	Gene_with_Unknown_or_Unclassified_Function	WHSC1 Gene|MMSET Gene|NSD2 Gene|TRX5 Gene|WHSC1|Wolf-Hirschhorn Syndrome Candidate 1 Gene	Human oncogene WHSC1 Gene at 4p16.3 partially resides in the 165 kb WHS critical region. The 25-exon WHSC1 gene transcript undergoes complex alternative splicing and differential polyadenylation. It encodes a 136 kD Wolf-Hirschhorn Syndrome Candidate 1 Protein containing a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. WHSC1 is preferentially expressed in rapidly growing embryonic tissues, in a pattern corresponding to affected organs in WHS patients. The nature of the protein motifs, the expression pattern, and its mapping to the critical region suggest that WHSC1 is a good candidate responsible for many of the phenotypic features of WHS; a malformation syndrome associated with hemizygous deletion of the chromosome 4 distal short arm.  (Omim, Swiss-Prot, LocusLink, and NCI)
C21417	WISP2_Gene	Signaling_Pathway_Gene	WISP2 Gene|WISP2|WNT1 Inducible Signaling Pathway Protein 2 Gene	Human oncogene WISP2 Gene at 20q12-q13.1 constitutes one of three genes - WISP1, WISP2, and WISP3 - that encode factors downstream in the WNT signaling pathway relevant to malignant transformation. WISP2 encodes a 250-amino acid WNT1 Inducible Signaling Pathway Protein 2. Expression is reduced in 79% of human colon tumors; WISP1 and WISP3 are over expressed in colon tumors.  (Omim, Swiss-Prot, LocusLink, and NCI)
C21418	WISP3_Gene	Signaling_Pathway_Gene	WISP3 Gene|WISP3|WNT1 Inducible Signaling Pathway Protein 3 Gene	Human oncogene WISP3 Gene (CCN Family) at 6q22-q23 constitutes one of three genes - WISP1, WISP2, and WISP3 - that encode factors downstream in the WNT signaling pathway relevant to malignant transformation. WISP3 resides 18 Mb proximal to CTGF at 6q23.1 and 23 Mb proximal to MYB at 6q22. CCN genes encode cell- and tissue-specific cysteine-rich secreted proteins with roles in cell growth and differentiation. WISP3 encodes a 354-amino acid WNT1 Inducible Signaling Pathway Protein 3 essential for skeletal growth and cartilage homeostasis; mutations are associated with progressive pseudorheumatoid dysplasia. WISP1 and WISP3 are over expressed in colon tumors; WISP2 expression is reduced.  (Omim, Swiss-Prot, LocusLink, and NCI)
C21419	WNT2B_Gene	WNT_Family_Gene	WNT2B Gene|WNT13 Gene|WNT2B|Wingless-Type MMTV Integration Site Family, Member 2B Gene|XWNT2 Gene	Human oncogene WNT2B Gene (WNT Family) at 1p13 encodes a novel 372-amino acid WNT2B Protein homolog of Xenopus Xwnt2. WNT2B is expressed as a 2.5-kb mRNA in fetal brain, lung, and kidney, and in a variety of adult tissues. Two isoforms are produced by alternative splicing. Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine, and colon. Isoform 2 is expressed in fetal brain, lung, and kidney, and in adult brain and testis. Highly-conserved WNT genes encode 350-400 amino acid, cysteine-rich, short-range glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. (NCI)
C21420	WNT6_Gene	WNT_Family_Gene	WNT6 Gene|WNT6|Wingless-Type MMTV Integration Site Family, Member 6 Gene	Highly-conserved WNT genes encode 350-400 amino acid, cysteine-rich, short-range glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. The WNT6 Gene (WNT Family) at 2q35 encodes WNT6 Protein, which contains conserved residues, two N-linked glycosylation sites, an N-terminal signal peptide, and an RGD motif. A 2 kb transcript is expressed in brain, testis, placenta, and spleen. It shares 47.4% sequence identity with WNT1. Aberrant WNT6 expression may contribute to tumorigenesis and WNT6 is overexpressed in HeLa, cervical cancer, and colorectal cancer cell lines. (OMIM, Swiss-Prot, LocusLink and NCI)
C21421	WNT10A_Gene	WNT_Family_Gene	WNT10A Gene|WNT10A|Wingless-Type MMTV Integration Site Family, Member 10A Gene	Human WNT10A Gene (WNT Family) encodes WNT10A Protein, a putative ligand for a member(s) of the frizzled family of seven transmembrane receptors. WNT10A may be a signaling molecule in CNS development. Highly-conserved WNT genes encode 350-400 amino acid, cysteine-rich, short-range signaling glycoproteins involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues.  (Omim, Swiss-Prot, LocusLink, and NCI)
C21422	Class-II_AP-Endonuclease	Deoxyribonuclease	Class II AP Endonuclease	Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. (From LocusLink 27301)
C21423	Apurinic-Apyrimidinic_Endonuclease-2	Class-II_AP-Endonuclease	Apurinic/Apyrimidinic Endonuclease 2|APEX Nuclease-Like 2|APEXL2|Apurinic/Apyrimidinic Endonuclease-Like 2	Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. Apurinic/Apyrimidinic Endonuclease 2, a protein encoded by the APEXL2 gene, has a weak class II AP endonuclease activity. Most of this protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair (BER). (From LocusLink 27301)
C21424	WNT11_Gene	WNT_Family_Gene	WNT11 Gene|WNT11|Wingless-Type MMTV Integration Site Family, Member 11 Gene	Human WNT11 Gene (WNT Family) at 11q13.5 contains five exons encoding the WNT11 Protein expressed in fetal ureteric bud tips, perichondrium, lung mesenchyme, urorectal septum, urogenital folds, labioscrotal swellings, and adrenal gland cortex as well as adult heart, liver, skeletal muscle, and pancreas. Highly-conserved WNT genes encode 350-400 amino acid, cysteine-rich, short-range glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. WNT11 activity may drive vertebrate gastrulation; the WNT11 homolog of zebrafish (slb) is required for gastrulation. WNT11 also appears to be required for heart formation in higher vertebrates, mediated by noncanonical WNT-Dishevelled signaling, independent of beta-catenin, and involving PKC and JNK.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21425	WNT14_Gene	WNT_Family_Gene	WNT9A Gene|WNT14|WNT14 Gene|WNT9A|Wingless-Type MMTV Integration Site Family, Member 14 Gene|Wingless-Type MMTV Integration Site Family, Member 9A Gene	The WNT14 gene (WNT Family) at 1q42 encode a 4.4 kb transcript in adult skeletal muscle, heart, lung, pancreas, spleen, ovary, and placenta, and in fetal brain and lung. The WNT14 gene encodes WNT14 Protein, which contains an N-linked glycosylation site. WNT14 shows 54% identity to human WNT15. WNT14 and WNT15 are most related to Drosophila Wnt4 and hagfish Wnt9 and may share a common ancestry. Highly-conserved WNT genes encode 350-400 amino acid, cysteine-rich, short-range glycoprotein ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. Wnt14 initiates synovial joint formation in chick limb and is expressed in joint-forming regions where it induces the first steps of joint formation.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21426	WSX1_Gene	Cytokine_Receptor_Gene	IL27RA Gene|CRL1|Class I Cytokine Receptor Gene|IL27RA|TCCR|WSX1|WSX1 Gene	Human WSX1 Gene at 19p13.11 encodes WSX1 Class I Cytokine Receptor, which is most homologous to IL12RB2 and 62% identical to mouse Tccr. A 3.5 kb transcript is seen in PBL, thymus, spleen, and lung. Highest expression occurs in CD4+ T cells and natural killer cells. Among CD4+ T cells, expression is highest in Th0 cells, with reduced expression in Th1 and Th2 cells. The deduced 636-amino acid protein exhibits a single transmembrane domain, a WSX signature motif, seven potential extracellular N-glycosylation sites, and an intracellular BOX1 motif.  (Omim, Swiss-Prot, LocusLink, and NCI)
C21427	XCR1_Gene	Cytokine_Receptor_Gene	XCR1 Gene|CCXCR1|Chemokine (C Motif) Receptor 1 Gene|GPR5|XCR1	Human XCR1 Gene (GPCR Family 1) at 3p21.3-p21.1 encodes within a single exon a 333-amino acid seven transmembrane protein, Chemokine (C Motif) XC Receptor 1, most closely related to RBS11 and MIP1-alpha/RANTES receptor. Strong expression of a 5 kb transcript occurs in placenta, spleen, and thymus. GPR5 is a receptor for chemokines XCL1 (SCYC1) and XCL2 (SCYC2). Cells expressing GPR5 mobilize intracellular calcium and migrate in response to SCYC1 and SCYC2. Migration is suppressed by pertussis toxin, indicating that the receptor is coupled to a G-alpha protein.  (Omim, Swiss-Prot, LocusLink, and NCI)
C21428	YARS_Gene	Ligase_Gene	YARS Gene|TYRRS|Tyrosyl-tRNA Synthetase Gene|YARS|YRS|YTS	Human YARS Gene (Class-I Aminoacyl-tRNA Synthetase Family) at 1p34.3 encodes a 528-amino acid Tyrosyl-tRNA Synthetase. Likely to be among the first proteins to appear in evolution, amino acyl-tRNA synthetases catalyze tRNA amino acylation by their cognate amino acid. Under apoptotic conditions, tyrosyl-tRNA synthetase may be secreted and cleaved into an N-terminal IL8-like cytokine fragment that harbors the catalytic site and a C-terminal EMAP II-like cytokine fragment.  (Omim, Swiss-Prot, LocusLink, and NCI)
C21429	YWHAQ_Gene	Adaptor_Signaling_Protein_Gene	YWHAQ Gene|1C5|HS1|Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Theta Polypeptide Gene|YWHAQ	Human YWHAQ Gene (14-3-3 Family) on chromosome 2 encodes a cytoplasmic homodimeric YWHAQ Protein. 14-3-3 proteins are localized in neurons and are axonally transported to the nerve terminals. 14-3-3 proteins may be present in other tissues as well. A probable multifunctional regulator of cell signaling processes, YWHAQ Protein strongly activates PKC as well as tyrosine and tryptophan hydroxylases in the presence of Ca(2+)/calmodulin-dependent protein kinase II.  (Swiss-Prot, LocusLink, and NCI)
C21430	Protein_Kinase-ATR	Kinase	Ataxia Telangiectasia and Rad3 Related Protein|ATR|FRAP-Related Protein-1|FRP1|Protein Kinase ATR|Rad3 Related Protein	Ataxia Telangiectasia and Rad3 Related Protein (ATR), encoded by the ATR gene, is a member of the PIK (phosphatidylinositol kinase)-related kinase family that are high molecular weight kinases involved in cell cycle progression, DNA recombination, and the detection of DNA damage. ATR is essential for the viability of human somatic cells. ATR and ATRIP (ATR-interacting protein) are mutually dependent partners in cell cycle checkpoint signaling pathways - ATR phosphorylates ATRIP that regulates ATR expression and is an essential component of the DNA damage checkpoint pathway. ATR phosphorylates checkpoint kinase CHK1, checkpoint proteins RAD17, and RAD9, as well as tumor suppressor protein BRCA1. ATR may be particularly essential in the early embryo to sense incomplete DNA replication and prevent mitotic catastrophe. (From OMIM, LocusLink and NCI)
C21431	ZFP36L2_Gene	Ligand_Binding_Protein_Gene	ZFP36L2 Gene|BRF2|ERF2|TIS11D|ZFP36L2|Zinc Finger Protein 36, C3H Type-Like 2 Gene	Human oncogene ZFP36L2 Gene at 2p22.3-p21 encodes a putative nuclear regulatory Zinc Finger Protein 36 C3H Type-Like 2 containing two C3H1-type zinc fingers and involved in growth factor response.  (Swiss-Prot, LocusLink, and NCI)
C21432	ZNF151_Gene	Ligand_Binding_Protein_Gene	ZBTB17 Gene|MIZ1|ZBTB17|ZNF151|ZNF151 Gene|Zinc Finger Protein 151 Gene|Zinc Finger and BTB Domain Containing 17 Gene	Human oncogene ZNF151 Gene (Kruppel Family) at 1p36.2-p36.1 encodes Zinc Finger Protein 151, highly expressed in brain and muscle and containing an N-terminal BTB/POZ domain and thirteen C2H2 zinc finger domains connected by conserved H/C links. Located mainly in the cytosol, ZNF151 exerts a potent growth arrest function that may involve transcriptional activation of growth inhibitory genes; cells progress into S phase but not into mitosis. ZNF151 is regulated by association with microtubules and may activate gene transcription in response to changes in the cytoskeleton. ZNF151 can transactivate the cyclin D1 (CCND1) promoter and activates alpha-2 integrin and LDLR transcription. ZNF151 interacts specifically with the HLH domain of MYC and NMYC. MYC interaction inhibits ZNF151 transactivation, induces ZNF151 nuclear sequestration, and overcomes ZNF151-induced growth arrest. (OMIM, Swiss-Prot, LocusLink and NCI)
C21433	ZNF217_Gene	Ligand_Binding_Protein_Gene	ZNF217 Gene|ZABC1|ZNF217|Zinc Finger Protein 217 Gene	Human oncogene ZNF217 Gene (Kruppel Family) at 20q13.2 encodes Zinc Finger Protein 217 isoforms, widely expressed transcription factors of 1,062 and 1,108 amino acids having a DNA-binding domain (eight C2H2-type zinc fingers) and a proline-rich transcription activation domain. The gene is over expressed in cell lines and in tumors in which it is amplified.  (Omim, Swiss-Prot, LocusLink, and NCI)
C21434	Chemokine_C_Motif_XC_Receptor_1	Retired_Concepts	Chemokine (C Motif) XC Receptor 1
C21435	Class-I_Cytokine_Receptor	Cytokine_Receptor	Class I Cytokine Receptor|CRL1 Protein|T-Cell Cytokine Receptor|TCCR|WSX1	A cytokine receptor is a protein on the cell surface that specifically binds cytokine ligands which are small proteins secreted by immune cells. These receptors mediate molecular functions such as signal transduction.
C21436	Tyrosyl-tRNA_Synthetase	Ligase	Tyrosyl-tRNA Synthetase|EC 6.1.1.1|Tyrosine-transfer RNA Ligase|Tyrosyl-tRNA Ligase|YARS	Encoded by human YARS Gene, the 528-amino acid Tyrosyl-tRNA Synthetase polypeptide belongs to the Class-I Aminoacyl-tRNA Synthetase Family. Likely to be among the first proteins to appear in evolution, amino acyl-tRNA synthetases catalyze tRNA amino acylation by their cognate amino acid. Under apoptotic conditions, tyrosyl-tRNA synthetase may be secreted and cleaved into an N-terminal IL8-like cytokine fragment that harbors the catalytic site and a C-terminal EMAP II-like cytokine fragment.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21437	Excision_Repair_Cross-Complementing-1_Protein	DNA_Repair_Protein	Excision Repair Cross-Complementing 1|DNA Excision Repair Protein ERCC-1|ERCC1	DNA excision repair protein ERCC-1, encoded by the ERCC1 gene, is a structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Its C-terminal is essential for enzymatic activity and the central region is involved in protein-protein interactions. The ERCC1 gene is involved in UV cross-link repair and nucleotide excision repair (NER). With p53 monitoring DNA damage, either XPA loads and possibly orients an incision complex, containing ERCC1 and other repair factors, to the site of DNA damage or XPA, ERCC1, and ERCC4 proteins form a ternary complex that participates in both damage recognition and incision activities. In the absence of DNA damage, the complex moved freely through the nucleus. Ultraviolet light-induced DNA damage causes a transient immobilization of ERCC1/XPF to engage the complex in a single repair event. Afterwards, the complex regains mobility. (From OMIM 126380 and NCI)
C21438	DNA_Repair_Endonuclease	Deoxyribonuclease	DNA Repair Endonuclease	DNA Repair Endonucleases specifically catalyze the hydrolysis of interior DNA phosphodiester bonds during correction of errors in DNA structure and sequence to protect genetic information against chemical, radiation or spontaneous damage and against replication errors, and to restore DNA to its original state.
C21439	Ubiquitin_Specific_Protease-6	Protease	Ubiquitin Specific Protease 6|Deubiquitinating Enzyme 6|USP6|Ubiquitin Carboxyl-Terminal Hydrolase 6|Ubiquitin Thiolesterase 6|Ubiquitin-Specific Processing Protease 6	Encoded by human TRE2 Gene, some evidence suggests that human Ubiquitin Specific Protease 6 (C19 Peptidase Family) may actually be encoded by separate elements on chromosomes 5, 18, and 17. The 1089-amino acid 122 kD hydrophilic protein contains two charge clusters, suggesting nucleic acid-binding properties. Ubiquitin Specific Protease 6 appears to have ATP-independent isopeptidase activity, cleaving at the carboxyl terminus of ubiquitin.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21440	Ubiquitin_Specific_Protease-8	Protease	Ubiquitin Specific Protease 8|Deubiquitinating Enzyme 8|Deubiquitinating Enzyme HUMORF8|USP8|Ubiquitin Carboxyl-Terminal Hydrolase 8|Ubiquitin Thiolesterase 8|Ubiquitin-Specific Processing Protease 8	Encoded by human USP8 Gene (C19 Peptidase Family), Ubiquitin Specific Protease 8 is a deubiquitinating enzyme related to the TRE2 oncogene product that cleaves at the carboxyl terminus of ubiquitin. In chronic myeloproliferative disorder, an oncogenic fusion of p85-beta occurs with the carboxyl end of USP8.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21441	Vascular_Endothelial_Growth_Factor-C	Angiogenesis_Promoter	Vascular Endothelial Growth Factor C|FLT4 Ligand|FLT4-L|VEGF-C|VEGFC|VRP|Vascular Endothelial Growth Factor Related Protein	Encoded by human VEGFC Gene (PDGF/VEGF Family), VEGFC is expressed in spleen, lymph node, thymus, appendix, bone marrow, heart, placenta, ovary, skeletal muscle, prostate, testis, colon, and small intestine, as well as fetal liver, lung, and kidney. Active in angiogenesis, endothelial growth, and vascular permeability, VEGFC may maintain adult lymphatic endothelium. A FLT4 ligand, VEGFC is a 419-amino acid 47 kD (precursor) disulfide-linked homodimeric secreted polypeptide with C-terminal cysteine-rich BR3P repeats and similar to VEGF and VEGFB/VRF. VEGFC can also activate endothelial VEGFR2 (KDR/FLK1). VEGFC proteolytic maturation generates isoforms with increased VEGFR3 activity; fully processed VEGFC activates VEGFR2. Mature VEGFC is mostly composed of two VEGF homology domains bound by non-covalent interactions.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21442	Vasoactive_Intestinal_Peptide	Peptide_Hormone	Vasoactive Intestinal Peptide|PHM27|VIP|Vasoactive Intestinal Polypeptide	Encoded by human oncogene VIP Gene (Glucagon-Secretin Family), VIP is a 170-amino acid 19 kD (precursor) octacosameric gastrointestinal peptide and a neuroendocrine mediator in CNS cholinergic neurons and PNS peptidergic neurons. VIP also affects B- and T cells directly. Prepro-VIP contains VIP and 27-amino acid PHM27. A neuropeptide in the lymphoid microenvironment, VIP has anti-inflammatory action, modulates innate and adaptive immunity, causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis, and relaxes the smooth muscle of trachea, stomach and gall bladder. VIP promotes TH2 differentiation and inhibits TH1 responses by regulating macrophage co-stimulatory signals.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21443	Vasoactive_Intestinal_Peptide_Receptor-1	G_Protein-Coupled_Receptor	Vasoactive Intestinal Peptide Receptor 1|PACAP Receptor, Type II|PACAP Type II Receptor|PACAP-R2|Pituitary Adenylate Cyclase Activating Polypeptide Type II Receptor|Pituitary Adenylate Cyclase-Activating Polypeptide Receptor, Type II|RDC1|VIP Receptor, Type I|VIPR|VIPR1|Vasoactive Intestinal Polypeptide Receptor 1	Encoded by human VIPR1 Gene (GPCR Family 2), Vasoactive Intestinal Peptide Receptor 1 appears to be expressed in brain, heart, kidney, liver, colonic epithelia, and placenta. The 457-amino acid 51.5 kD (precursor) G protein-coupled receptor contains seven transmembrane domains. Distinct subsets of neural, respiratory, gastrointestinal, and immune cells bear high-affinity VIP G protein receptors, capable of activating adenylate cyclase.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21444	VAV3_Protein	Guanine_Nucleotide_Exchange_Factor	VAV3 Protein|VAV-3 Protein|VAV3	Encoded by human VAV3 Gene (VAV Family), the 847-amino acid VAV-3 Protein exhibits similarity to VAV1 and VAV2. Alpha and beta isoforms are expressed in peripheral blood lymphocytes, spleen, brain, thymus, heart, kidney, liver, placenta, and lung. VAV3 contains DBL and pleckstrin homology domains, a calponin homology region, an acidic motif, a DAG binding domain, two SH3 regions, and a SH2 domain. VAV3.1 Protein variant contains only the C-terminal SH3-SH2-SH3 region. Regulating the actin cytoskeleton and transcription, VAV3 acts as a GEF on RHOA, RHOG, and RAC1. VAV1, VAV2, and VAV3 respond to similar cell surface receptor tyrosine kinases. VAV3 is rapidly phosphorylated on TCR or EGFR activation. VAV1 and VAV3 enhance NFKB-dependent transcription. Integrin-induced phosphorylation requires SYK.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21445	WNT1_Inducible_Signaling_Pathway_Protein-2	Signaling_Protein	WNT1 Inducible Signaling Pathway Protein 2|BA445H22.2|Connective Tissue Growth Factor-Like Protein WISP2|WISP2|WISP2 Protein	Encoded by human oncogene WISP2 Gene, the 250-amino acid WNT1 Inducible Signaling Pathway Protein 2 constitutes - with WISP1 and WISP3 - one of three factors downstream in the WNT signaling pathway relevant to malignant transformation. WISP2 expression is reduced in 79% of human colon tumors; WISP1 and WISP3 are over expressed in colon tumors.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21446	DNA_Excision_Repair_Protein-ERCC2	DNA_Repair_Protein	DNA Excision Repair Protein ERCC-2|CXPD|DNA-Repair Protein Complementing XP-D Cells|DNA-Repair Protein XPD|ERCC2|Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 2 Protein|TFIIH Basal Transcription Factor Complex Helicase Subunit|Xeroderma Pigmentosum Group D Complementing Protein	Encoded by human ERCC2 Gene (RAD3/XPD Family), 760-aa 87-kDa nuclear DNA Excision Repair Protein ERCC2 is an ATP-dependent 5 prime-3 prime DNA helicase and one of six integral subunits of the basal transcription factor BTF2/TFIIH complex. Recruited by transcription preinitiation or DNA damage recognition complexes, ERCC2 is involved in RNA polymerase II transcription, transcription-coupled nucleotide excision DNA repair, and cell cycle regulation. ERCC2/MAT1 anchors CAK complex to the TFIIH complex. CAK inhibits ERCC2 helicase activity; overcome by binding TFIIH subunit p44, which stimulates helicase activity. ERCC2 defects result in XPD, XPD/CS, TTD, and COFS Syndrome. (NCI)
C21447	WNT1_Inducible_Signaling_Pathway_Protein-3	Signaling_Protein	WNT1 Inducible Signaling Pathway Protein 3|Connective Tissue Growth Factor Related Protein WISP-3|WISP3|WISP3 Protein	Encoded by human oncogene WISP3 Gene (CCN Family), the 354-amino acid 39.3 kD WNT1 Inducible Signaling Pathway Protein 3 constitutes - with WISP1 and WISP2 - one of three factors downstream in the WNT signaling pathway relevant to malignant transformation. CCN proteins are cell- and tissue-specific cysteine-rich secreted factors with roles in cell growth and differentiation. WISP3 protein is essential for skeletal growth and cartilage homeostasis; mutations are associated with progressive pseudorheumatoid dysplasia. WISP3 is over expressed in colon tumors.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21448	WNT2B_Protein	WNT_Family_Protein	WNT2B Protein|WNT-2B Protein|WNT13 Protein|WNT2B|Wingless-Type MMTV Integration Site Family Member 2B Protein|XWNT2 Protein	Encoded by human oncogene WNT2B Gene (WNT Family), the novel 391-amino acid 43.8 kD (precursor) WNT2B Protein is a homolog of Xenopus Xwnt2 and expressed in fetal brain, lung, and kidney, as well as in a variety of adult tissues.  Isoform 1 is expressed in adult heart, brain, placenta, lung, prostate, testis, ovary, small intestine, and colon.  Isoform 2 is expressed in fetal brain, lung, and kidney, and in adult brain and testis.  Highly-conserved, 350-400 amino acid WNT glycoproteins constitute cysteine-rich, short-range ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. (NCI)
C21449	WNT6_Protein	WNT_Family_Protein	WNT6 Protein|WNT-6 Protein|WNT6|Wingless-Type MMTV Integration Site Family Member 6 Protein	Encoded by human WNT6 Gene (WNT Family), WNT6 Protein is expressed in brain, testis, placenta, and spleen. In mouse embryos, Wnt6 is expressed panectodermally, in somites, in limb bud, and in the reproductive system. In adult mice, Wnt6 is expressed in the mammary gland. WNT6 encodes a 365-amino acid 39.7 kD (precursor) peptide containing conserved residues, two N-linked glycosylation sites, an N-terminal signal peptide, and an RGD motif. Highly-conserved, 350-400 amino acid WNT glycoproteins constitute cysteine-rich, short-range ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21450	WNT10A_Protein	WNT_Family_Protein	WNT10A Protein|WNT-10A Protein|WNT10A|Wingless-Type MMTV Integration Site Family Member 10A Protein	Encoded by human WNT10A Gene (WNT Family), 417-amino acid 46 kD (precursor) WNT10A Protein is a putative ligand for a member(s) of the frizzled family of seven transmembrane receptors and may be a signaling molecule in CNS development. Highly-conserved, 350-400 amino acid WNT glycoproteins constitute cysteine-rich, short-range ligands involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21451	WNT11_Protein	WNT_Family_Protein	WNT11 Protein|WNT-11 Protein|WNT11|Wingless-Type MMTV Integration Site Family Member 11 Protein	Encoded by human WNT11 Gene (WNT Family), the 354-amino acid 39 kD (precursor) WNT11 protein is expressed in fetal ureteric bud tips, perichondrium, lung mesenchyme, urorectal septum, urogenital folds, labioscrotal swellings, and adrenal cortex as well as adult heart, liver, skeletal muscle, and pancreas. Highly-conserved, 350-400 amino acid WNT glycoproteins constitute cysteine-rich, short-range ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. WNT11 may drive vertebrate gastrulation; homolog slb (zebrafish) is required for gastrulation. WNT11 may be required for vertebrate heart formation, mediated by noncanonical WNT-Dishevelled signaling; independent of beta-catenin and involving PKC and JNK.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21452	DNA_Excision_Repair_Protein-ERCC3	DNA_Repair_Protein	DNA Excision Repair Protein ERCC-3|BTF2-p89|Basic Transcription Factor 2 89 kDa Subunit|DNA-Repair Protein Complementing XP-B Cells|EC 3.6.1.-|ERCC3|Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 3 (Xeroderma Pigmentosum Group B Complementing)|TFIIH 89 kDa Subunit|TFIIH Basal Transcription Factor Complex Helicase XPB Subunit|Xeroderma Pigmentosum Group B Complementing Protein	DNA Excision Repair Protein ERCC-3, encoded by the ERCC3 gene, is an ATP-dependent DNA helicase that functions in nucleotide excision repair and complements xeroderma pigmentosum group B mutations. This protein is also the 89 kDa subunit of basal transcription factor 2 (TFIIH) and thus functions in class II transcription. (from LocusLink 2071 and NCI)
C21453	WNT14_Protein	WNT_Family_Protein	WNT14 Protein|WNT-14 Protein|WNT14|Wingless-Type MMTV Integration Site Family, Member 14 Protein	Encoded by human WNT14 Gene (WNT Family), the 365-amino acid 40 kD (precursor) WNT14 Protein is seen in adult skeletal muscle, heart, lung, pancreas, spleen, ovary, and placenta, and in fetal brain and lung. WNT14 is most related to Drosophila Wnt4. Highly-conserved, 350-400 amino acid WNT glycoproteins constitute cysteine-rich, short-range ligands for frizzled family seven transmembrane receptors involved in embryonic cell fate determination and patterning, as well as cell growth or differentiation in some adult mammalian tissues. Wnt14 initiates synovial joint formation in chick limb and is expressed in joint-forming regions where it induces the first steps of joint formation.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21454	Wolf-Hirschhorn_Syndrome_Candidate-1_Protein	Protein_with_Unknown_or_Unclassified_Function	Wolf-Hirschhorn Syndrome Candidate 1 Protein|MMSET Protein|Multiple Myeloma Set Domain Protein|NSD2 Protein|Nuclear Set Domain-Containing 2 Protein|WHSC1|WHSC1 Protein	Encoded by human oncogene WHSC1 Gene, 1365-amino acid 152 kD Wolf-Hirschhorn Syndrome Candidate 1 Protein contains a PWWP domain, an HMG box, a SET domain, and a PHD-type zinc finger. WHSC1 is preferentially expressed in rapidly growing embryonic tissues, in a pattern corresponding to affected organs in WHS patients. The nature of the protein motifs and expression pattern suggest that WHSC1 is a good candidate responsible for many of the phenotypic features of WHS; a malformation syndrome associated with hemizygous deletion of the chromosome 4 distal short arm.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21455	YWHAQ_Protein	Adaptor_Signaling_Protein	Tyrosine 3/Tryptophan 5 -Monooxygenase Activation Protein, Theta Polypeptide|14-3-3 Protein T-Cell|14-3-3 Protein Tau|14-3-3 Protein Theta|HS1 Protein|Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein, Theta Polypeptide|YWHAQ|YWHAQ Protein	Encoded by human YWHAQ Gene, 245-amino acid 27.8 kD YWHAQ Protein is a cytoplasmic homodimeric 14-3-3 family protein. 14-3-3 proteins are localized in neurons, and are axonally transported to the nerve terminals. 14-3-3 proteins may be present in other tissues as well. A probable multifunctional regulator of cell signaling processes, YWHAQ Protein strongly activates PKC and activates tyrosine and tryptophan hydroxylases in the presence of Ca(2+)/calmodulin-dependent protein kinase II.  (Swiss-Prot, LocusLink, and NCI)
C21456	EGF-Response_Factor-2	Nuclear_Protein	Zinc Finger Protein 36 C3H Type-Like 2|Butyrate Response Factor 2|EGF-Response Factor 2|ERF-2 Protein|TIS11D Protein|ZFP36L2	Encoded by human oncogene ZFP36L2 Gene, 492-amino acid 50.9 kD Zinc Finger Protein 36 C3H Type-Like 2 is a putative nuclear regulatory protein containing two C3H1-type zinc fingers and involved in growth factor response.  (Swiss-Prot, LocusLink, and NCI)
C21457	Zinc_Finger_Protein-151	Transcription_Factor	Zinc Finger Protein 151|MIZ-1 Protein|MIZ17709|MYC-Interacting Zinc Finger Protein 1|ZNF151	Encoded by human oncogene ZNF151 Gene (Kruppel Family) and highly expressed in brain and muscle, 803-amino acid 88 kD Zinc Finger Protein 151, similar to Z13 (mouse), contains an N-terminal BTB/POZ domain and thirteen C2H2 zinc finger domains connected by conserved H/C links. Predominantly cytoplasmic, ZNF151 may arrest growth (S/M) by activation of growth inhibitory genes. Associated with microtubules, ZNF151 may activate gene transcription in response to cytoskeletal changes. ZNF151 can transactivate cyclin D1 (CCND1,) alpha-2 integrin, and LDLR. ZNF151 interacts specifically with the HLH domain of MYC and NMYC. MYC interaction inhibits ZNF151 transactivation, induces ZNF151 nuclear sequestration, and overcomes ZNF151-induced growth arrest.  (OMIM, Swiss-Prot, and NCI)
C21458	Zinc_Finger_Protein-217	Transcription_Factor	Zinc Finger Protein 217|ZNF217|ZNF217 Protein	Encoded by human oncogene ZNF217 Gene (Kruppel Family), 1048-amino acid 115 kD Zinc Finger Protein 217 is a widely expressed transcription factor having a DNA-binding domain (eight C2H2-type zinc fingers) and a proline-rich transcription activation domain. ZNF217 is over expressed in cell lines and in tumors in which the gene is amplified.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C21459	DNA_Excision_Repair_Protein-ERCC4	DNA_Repair_Protein	DNA Excision Repair Protein ERCC-4|ERCC4|RAD1|XPF	DNA Excision Repair Protein ERCC-4, encoded by the ERCC4 gene, is a DNA repair protein. Nucleotide excision repair (NER) involves incision of a DNA strand on each side of a lesion. The two incisions made during NER are catalyzed by separate DNA endonucleases. A tight protein complex formed between ERCC4 and ERCC1 acts as a structure-specific endonuclease for the 5-prime incision during repair. Without DNA damage, this complex moves freely through the nucleus. Ultraviolet light-induced DNA damage causes a transient immobilization of ERCC4/ERCC1 due to engagement of the complex in a single repair event after assembly of individual nucleotide excision repair factors at sites of DNA damage in a distributive fashion. Causative mutations in the ERCC4 gene and strongly reduced levels of encoded protein can be identified in patients with xeroderma pigmentosum type F. (From OMIM and NCI)
C21460	DNA_Excision_Repair_Protein-ERCC5	DNA_Repair_Protein	DNA Excision Repair Protein ERCC-5|DNA-Repair Protein Complementing XP-G Cells|ERCC5|ERCM2|UVDR|XPG|XPG-Complementing Protein|XPGC|Xeroderma Pigmentosum Group G Complementing Protein	XPG-Complementing Protein, encoded by the ERCC5 gene is involved in transcription-coupled repair of UV-induced DNA damage. It is a single-strand specific DNA endonuclease that nicks damaged DNA 3-prime to the lesion in nucleotide excision repair as a result of the combined action of the XPB helicase and XPD helicase following sequential assembly of repair proteins at the DNA damage site. In addition, it associates with CSA, CSB, or both proteins at the transcriptional pause sites to facilitate the resumption of transcript elongation without aborting the associated nascent transcript by pushing the stalled RNA polymerase II either forward or backward not only from the damaged site but also from some natural transcription pause sites. Mutational inactivation of XPG causes Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. (from OMIM 133530, LocusLink 2073 and NCI)
C21461	DNA_Excision_Repair_Protein-ERCC6	DNA_Repair_Protein	DNA Excision Repair Protein ERCC-6|CSB Protein|Cockayne Syndrome B Repair Protein|ERCC6|ERCC6 Protein|Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 6	Excision Repair Protein ERCC-6 (ERCC6), encoded by the ERCC6 gene (SNF2/RAD54 Family), is a putative DNA or RNA unwinding helicase involved in transcription-coupled excision repair. This protein specifically interacts with CSA proteins and with p44, a subunit of the RNA Polymerase II basal transcription factor TFIIH. It has DNA-dependent ATP-stimulated ATPase activity that may have a role in the displacement of stalled RNA Polymerase II from sites of DNA lesion and in recruitment of a DNA repair component. ERCC6 inhibits fragility of RNU1, RNU2, and RN5S genes. p53 interacts with ERCC6 and activation of p53 inhibits ERCC6, stalling transcription complexes and blocking local chromatin condensation. Defects in ERCC6 are the cause of Cockayne's syndrome type B (CSB). (NCI)
C21462	Exonuclease-1	DNA_Repair_Protein	Exonuclease 1|EXO1|Exonuclease I	Exonuclease 1, encoded by the EXO1 gene, is a 88-kD protein with 5-prime to 3-prime double strand DNA exonuclease activity as well as an RNase H activity. It is similar to the Saccharomyces cerevisiae protein Exo1 which interacts with Msh2 and which is involved in mismatch repair and recombination. Alternative splicing of this gene results in three transcript variants encoding two different protein isoforms, a and b. (From LocusLink)
C21463	DNA_Ligase-IV	Ligase	DNA Ligase IV|DNA Joinase|DNA Repair Enzyme|EC 6.5.1.1|LIG4|Ligase IV, DNA, ATP-Dependent|Polydeoxyribonucleotide Synthase|Polynucleotide Ligase|Sealase	DNA ligase IV (LIG4), a 96-kD protein encoded by the LIG4 gene, belongs to the ATP-dependent DNA ligase family. LIG4 efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is the activity responsible for the ligation step in nonhomologous DNA end joining and in V(D)J recombination. Defects in LIG4 are the cause of LIG4 syndrome. (OMIM 601837)
C21464	DNA_Mismatch_Repair_Protein-MLH1	DNA_Repair_Protein	DNA Mismatch Repair Protein MLH1|COCA2|FCC2|HNPCC|HNPCC2|MGC5172|MLH1|MLH1 Gene Product|MLH1 Protein|MUTL Protein Homolog 1|Mismatch DNA Repair Protein MLH1|Mismatch Repair Protein MLH1|hMLH1 Protein	MLH1 protein is a DNA-binding, DNA-mismatch repair protein, of the MutL/HexB family, that dimerizes with PMS2 or MLH3.  MLH1 is part of the multi-subunit BASC repair complex containing ATM, BLM, MSH2, MSH6, BRCA1, the RAD50/MRE11/NBS1 complex, and the RFC1/RFC2/RFC4 complex.  MLH1 is homologous to MutL, which hydrolyzes ATP.  (from OMIM 120436 and NCI)
C21465	DNA_Mismatch_Repair_Protein-MLH3	DNA_Repair_Protein	DNA Mismatch Repair Protein MLH3|MLH3|MutL Protein Homolog 3	DNA Mismatch Repair Protein MLH3, encoded by the MLH3 gene, is ubiquitously expressed in various tissues and two isoforms are produced by alternative splicing. MLH3 interacts with MLH1 and shares the same interacting region on MLH1 with PMS1 and PMS2. The balance of these three competing MLH1 partners might be important in the repair of mismatches in DNA. Malfunction of the mismatch repair system results in a mutator phenotype, which is manifested as microsatellite instability (MSI). MSI is often divided into 2 forms: MSI-high (MSI-H) and MSI-low (MSI-L), based quantitatively on the observed frequency of genomic mutations. An appreciable frequency of somatic MLH3 mutations in MSI-H tumors is consistent with a possible role for this gene in the progression of colorectal cancer tumorigenesis. Germline mutations of the MLH3 gene may also play a role in hereditary nonpolyposis colorectal cancer (NCI)
C21466	DNA_Mismatch_Repair_Protein-MSH2	DNA_Repair_Protein	DNA Mismatch Repair Protein MSH2|MSH2|MutS Homolog 2	Alterations in MSH2 Protein are associated with DNA instability from defective repair of DNA replication errors that create mismatched nucleotides. MSH2 contains a highly conserved helix-turn-helix domain associated with an adenine nucleotide and magnesium binding motif and ATPase activity that regulates mismatch binding as a molecular switch. MSH2 protein binds DNA containing mismatches up to 14 nucleotides long. ADP-bound MSH/MSH6 binds mismatched nucleotides and ATP hydrolysis results in mismatch binding, while ADP/ATP exchange results in mismatch dissociation. MSH2 is part of the large multi-subunit BASC complex, which may sense abnormal DNA structures and/or regulate post-replication repair. MSH2 protein also interacts with G/T binding protein. MSH2 is a cloned gene for Hereditary Non-Polyposis Colon Cancer that causes colon cancer, endometrial cancer, and stomach cancer. (from OMIM and NCI)
C21467	DNA_Mismatch_Repair_Protein-MSH3	DNA_Repair_Protein	DNA Mismatch Repair Protein MSH3|DUP|Divergent Upstream Protein|MRP1|MSH3|Mismatch Repair Protein 1	DNA Mismatch Repair Protein MSH3, encoded by the MSH3 gene (MutS family), is a 127-kD mismatch repair (MMR) protein. Mismatch recognition in human cells is mediated by two heterodimers, MutS alpha (MSH2/MSH6) and MutS beta (MSH2/MSH3) with different mispair recognition properties and abilities. Both participate in repair of a dinucleotide insertion-deletion heterology but only MutS alpha restores base-base mismatch repair and shoulders primary responsibility for mismatch correction during replication. Predisposition to intestinal cancer requires loss of function of both Msh2/Msh6 and Msh2/Msh3 but Msh3 deficiency alone does not cause cancer predisposition. Mismatch repair deficiency can arise not only through mutation or transcriptional silencing of a mismatch repair gene, but also as a result of imbalance in the relative amounts of the MSH3 and MSH6 proteins because MutS alpha and MutS beta share a common component, MSH2. (NCI)
C21468	DNA_Mismatch_Repair_Protein-MSH6	DNA_Repair_Protein	DNA Mismatch Repair Protein MSH6|G/T Mismatch Binding Protein|G/T Mismatch-Binding Protein|GTBP|GTMBP|MSH6|MutS Homolog 6	The G/T Binding Protein (GTBP), encoded by the MSH6 gene, forms Mismatch-Binding Factor with MSH2. Associated with colon, endometrial, and stomach cancers, the MSH6 Gene is a cloned gene for Hereditary Non-Polyposis Colon Cancer. GTBP contains a PWWP domain, binds to G/T mismatches, is required for base/base and single-nucleotide insertion-deletion repairs, and increases the proficiency of two-four nucleotide insertion-deletion repair. ADP-bound MSH2/MSH6 binds to mismatched DNA, provoking ADP/ATP exchange and MSH2/MSH6 migration along the DNA backbone. DNA-bound, ATP-bound MSH2/MSH6 activates the repair machinery. MSH6 is part of the multisubunit BASC complex, which may sense abnormal DNA structures and regulate postreplication repair. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. (From SWISS-PROT, OMIM, and NCI)
C21469	TRAF6_Gene	Adaptor_Signaling_Protein_Gene	TRAF6 Gene|MGC:3310|TNF Receptor-Associated Factor 6 Gene|TRAF6	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas, human TRAF6 Gene (TRAF Family) encodes 522-aa 60-kDa oligomeric adapter protein and signal transducer TNF Receptor-Associated Factor 6, containing a MATH domain, a RING-type zinc finger, 2 TRAF-type zinc fingers, and a coiled coil domain that mediates homo- and hetero-oligomerization. The MATH/TRAF domain binds to receptor cytoplasmic domains. In mediating TNFR and Toll/IL-1 family signal transduction to diverse pathways, TRAF6 interacts with TNFRSF5, -11A, -11B, -16 and -17, SRC, PKC zeta, IRAK1, -2, and -3, RIPK2, MAP3K1, -5, and -14, CSK, TRIP, TRAF, TTRAP, PELI1, PELI2, and PELI3. TRAF6 activates IKK in the NF-kappa B pathway in response to proinflammatory cytokines and is involved in the IL-1 signaling pathway via MYD88 and IRAK kinases. (NCI)
C21470	TRAG3_Gene	Gene_with_Unknown_or_Unclassified_Function	CSAG2 Gene|CSAG Family, Member 2 Gene|CSAG2|TRAG3|TRAG3 Gene|Taxol Resistance Associated Gene 3	Encodes a novel cancer/testis antigen overexpressed in melanoma cell lines and malignant melanoma. (from Anticancer Res 2000;20:4147-51)
C21471	Oncogenesis	Pathogenesis	Oncogenesis	The causation or production of tumors.
C21472	TRC8_Gene	Ligase_Gene	RNF139 Gene|HRCA1|Multiple Membrane Spanning Receptor TRC8 Gene|RCA1|RNF139|Ring Finger Protein 139 Gene|TRC8|TRC8 Gene	Human TRC8 Gene encodes Multiple Membrane Spanning Receptor TRC8, a multi-membrane spanning ER protein containing a RING-H2 zinc finger with ubiquitin ligase activity. TRC8 may interact with tumor suppressor protein VHL as well as with COPS5/JAB1, responsible for degradation of tumor suppressor CDKN1B/p27KIP. (NCI)
C21473	TRIM_Gene	Signaling_Pathway_Gene	TCRIM Gene|HSPC062|T-Cell Receptor Interacting Molecule Gene|TCRIM|TRIM	Expressed as a 2-kb transcript in T cells (not B cells or monocytes) of the thymus, spleen, lymph nodes, and peripheral leukocytes, 32-kb 6-exon human TRIM Gene encodes 186-aa 29/30-kD disulfide-linked dimeric type III transmembrane adaptor phosphoprotein T-Cell Receptor Interacting Molecule, containing an 8-aa extracellular domain (includes a Cys residue), a 19-aa transmembrane region and an intracellular domain with 4 potential phosphorylation sites likely involved in SH2-mediated interactions with signaling proteins. Associated with CD3E and CD3Z, TRIM modulates the TCR-CD3 complex in T lymphocytes. After T-cell activation, TRIM is tyrosine phosphorylated by Src kinases and associates with PIK3R1. (NCI)
C21474	TRIO_Gene	Signaling_Pathway_Gene	TRIO Gene|TRIO|Triple Functional Domain (PTPRF Interacting) Gene|Triple Functional Domain Gene	Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney, and lung, human TRIO Gene (Ser/Thr Kinase Family) encodes 3038-aa 342-kDa serine phosphorylated Triple Functional Domain Protein, containing a Ser/Thr kinase domain, 2 DH domains, a CRAL-TRIO domain, an Ig-like C2-type domain, 2 PH domains, an SH3 domain, and 4 spectrin repeats. The N-terminal DBL(DH)/GEF domain catalyzes RAC1 GDP/GTP exchange, leading to JUN kinase activation and membrane ruffling. The second DBL(DH)/GEF domain catalyzes RHOA GDP/GTP exchange, inducing stress fiber formation. Interacting with the cytoplasmic region of LAR tyrosine phosphatase, TRIO may coordinate cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth. (NCI)
C21475	Eight-Oxoguanine_DNA_Glycosylase	DNA_Repair_Protein	8-Oxoguanine DNA Glycosylase|N-Glycosylase/DNA Lyase|OGG1	The protein 8-Oxoguanine DNA Glycosylase, encoded by the OGG1 gene, is an enzyme in base excision repair. OGG1 incises DNA at 8-oxoguanine residues and excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-n-methylformamidopyrimidine (FAPY) from damaged DNA. OGG1 also has activities of beta-lyase that nicks DNA 3-prime to the lesion and endonuclease that cleaves DNA near apurinic or apyrimidinic sites to products with 5-prime-phosphate. Alternative splicing of the C-terminal region of the OGG1 gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common (1a/alpha, 1b, 1c, 2a/beta, 2b, 2c, 2d and 2e) and 1a is the prevalent form. OGG1 is ubiquitous and located in nucleus (isoform 1a) and mitochondria (isoform 2a). Defects in OGG1 are associated with tumor formation.
C21476	TRIP10_Gene	Ligand_Binding_Protein_Gene	TRIP10 Gene|CDC42 Homolog Gene|CDC42-Interacting Protein Gene|CIP4|G25K Gene|GP Gene|TRIP10|Thyroid Hormone Receptor Interactor 10 Gene	Expressed in skeletal muscle, heart, placenta, pancreas, lung, liver, kidney, and brain, human TRIP10 Gene encodes 545-aa 63-kDa Thyroid Hormone Receptor Interactor 10, containing an SH3 domain, an FCH domain, and similar to the non-kinase domains of FER and FES/FPS tyrosine kinases. Likely involved in CDC42 and WASP-dependent signal transduction, TRIP10 binds to activated CDC42 and may link CDC42 signaling with regulation of the actin cytoskeleton. TRIP10 specifically interacts (TH-dependent) with the ligand-binding domain of TR. (NCI)
C21477	DNA_Mismatch_Repair_Protein-PMS1	DNA_Repair_Protein	DNA Mismatch Repair Protein PMS1|Human Homolog of Yeast mutL|PMS1|Postmeiotic Segregation 1	DNA Mismatch Repair Protein PMS1, encoded by the PMS1 gene, is implicated, with MSH2 and MLH1, in mismatch repair of dinucleotide and trinucleotide sequences. A cloned gene for Hereditary Non-Polyposis Colon Cancer, the PMS1 Gene (MUTL/HEXB family) at 2q31-q33 is associated with colon, endometrial, and stomach cancers. Human PMSL genes exhibit homology to bacterial mutL genes and yeast PMS1 gene. (From SWISS-PROT, OMIM, and NCI)
C21478	Acrosin_Binding_Protein	Ligand_Binding_Protein	Acrosin Binding Protein|ACRBP|Proacrosin Binding Protein SP32	Encoded by human ACRBP Gene, 540-amino acid 61 kD Acrosin Binding Protein (CT Family) is similar to proacrosin binding protein sp32 precursor found in pig, mouse, and guinea pig.  Expressed in normal testis only, but detected in a range of tumor types such as bladder, breast, lung, liver, and colon, this immunogenic protein is located in the sperm acrosome and may package and condense proacrosin in the acrosomal matrix.  (from SWISS-PROT, LocusLink, and NCI)
C21479	DNA_Mismatch_Repair_Protein-PMS2	DNA_Repair_Protein	DNA Mismatch Repair Protein PMS2|DNA Mismatch Repair Gene Homolog|PMS2	Associated with colon, endometrial, and stomach cancers, DNA Mismatch Repair Protein PMS2, a 97-kD protein encoded by the ubiquitously expressed PMS2 Gene (MUTL/HEXB family) is involved with MSH2 and MLH1 in mismatch repair of dinucleotide and trinucleotide sequences. PMS2 is part of the BASC genome surveillance complex. MSH2 and MLH1 interact with PMS1, PMS2, and MSH6. Essential for repair of replication slippage errors, PMS2 is a cloned gene for Turcot syndrome and Hereditary Non-Polyposis Colon Cancer. Transcribed from the opposite strand, JTV1 overlaps PMS2. (From SWISS-PROT, OMIM, and NCI)
C21480	Relative	Person	Relative|RELTV	A person related by blood or marriage.
C21481	First_Degree_Relative	Relative	First Degree Relative	Any relative who is one meiosis away from a particular individual in a family; a relative with whom one half of an individual's genes is shared (i.e., parent, sibling, offspring) (from Genetics Home Reference glossary)
C21482	AGR2_Protein	Protein_with_Unknown_or_Unclassified_Function	AGR2 Protein|AG2|AGR2|Anterior Gradient 2 Homolog|GOB-4|HAG-2|Secreted Cement Gland Homolog|XAG-2	Encoded by human AGR2 Gene, soluble Anterior Gradient 2 Homologue Protein is 47% identical to the cement gland anterior gradient protein (Xenopus laevis) and 91% identical to the mouse protein.  Strongest expression is seen in the lung; weaker expression in the pancreas and other tissues.  Strong expression is also detected in trachea, stomach, colon, prostate, and small intestine.  (from OMIM, and NCI)
C21483	Protein_Kinase_DNA-Activated_Catalytic_Subunit	DNA_Repair_Protein	DNA-Activated Protein Kinase Catalytic Subunit|DNA-Dependent Protein Kinase|DNAPK|DNPK1|HYRC1|Hyper-Radiosensitivity Of Murine SCID Mutation, Complementing 1|PRKDC|XRCC7|p350	Protein Kinase, DNA-Activated, Catalytic Subunit (PRKDC), encoded by the PRKDC gene, is a nuclear protein serine/threonine kinase of a multiprotein complex DNA-dependent protein kinase (DNA-PK). Two protein isoforms are produced by alternative splicing and binds DNA for catalysis. PRKDC relies on the heterodimer Ku70/Ku80 autoantigen, the DNA-binding DNA-PK component, to direct it to DNA double-stranded breaks for other discontinuities in the DNA double helix and trigger its kinase activity. PRKDC is critical for repair of DNA double strand breaks via the nonhomologous DNA end joining, telomere maintenance via telomere capping, innate immune response via V(D)J recombination (where V is variable, D is diversity, and J is joining) as well as transcriptional regulation via p53, the site-specific recombination process in developing B and T lymphocytes to generate the variable regions of immunoglobulin and T cell receptor genes.
C21484	ANP32C_Protein	Protein_with_Unknown_or_Unclassified_Function	ANP32C Protein|ANP32C|Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family Member C Protein|Acidic Nuclear Phosphoprotein 32C	Encoded by human ANP32C Gene, 234-amino acid 27 kD PP32R1 Protein (PP32 Family) shares approximately 90% amino acid sequence identity with tumor suppressor PP32 and PP32R2.  PP32 can inhibit several types of cancers, including prostate and breast cancers.  PP32R1 and PP32R2 are tumorigenic.  Amino acids 150-174 of PP32 are responsible for its tumor suppressor function and are a region of divergence with PP32R1.  Alternative use of PP32, PP32R1, and PP32R2 may modulate the oncogenic potential of human prostate cancer.  (from SWISS-PROT, OMIM, and NCI)
C21485	ANP32D_Protein	Protein_with_Unknown_or_Unclassified_Function	ANP32D Protein|ANP32D|Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family Member D Protein|Acidic Nuclear Phosphoprotein 32D	Encoded by human ANP32D Gene, 131-amino acid 14.8 kD PP32R2 Protein (PP32 Family) shares approximately 90% amino acid sequence identity with tumor suppressor PP32 and PP32R1.  PP32 can inhibit several types of cancers, including prostate and breast cancers.  PP32R2 and PP32R1 are tumorigenic.  Amino acids 150-174 of PP32 are responsible for its tumor suppressor function and are a region of divergence with PP32R1. Alternative use of PP32, PP32R1, and PP32R2 may modulate the oncogenic potential of human prostate cancer.  PP32R2 is expressed in prostate cancer. (from SWISS-PROT, OMIM, and NCI)
C21486	Amyloid_Beta_Precursor_Protein-Binding_Protein_2	Transport_Protein	Amyloid Beta Precursor Protein-Binding Protein 2|APPBP2|Amyloid Beta Precursor Protein (Cytoplasmic Tail) Binding Protein 2|PAT1 Protein|Protein Interacting with APP Tail 1	Encoded by human APPBP2 Gene, ubiquitous 70 kD cytoplasmic Amyloid Beta Precursor Protein-Binding Protein 2 contains terminal globular structures, a coiled coil domain, PKC phosphorylation sites, and four imperfect C-terminal tandem repeats.  In the Golgi apparatus, APPBP2 is associated with transport or processing of amyloid precursor protein (APP).  Cell surface sorting of the signal-transducing APP depends on a cytoplasmic tyrosine-based basolateral sorting signal (BaSS) sequence to which APPBP2 specifically binds.  Amyloid BaSS tyrosine mutation prevents APPBP2 binding and results in nonpolarized transport.  Similar to the kinesin light chain, APPBP2 also interacts with microtubules and may have a role in vesicle sorting.  APPBP2 is abundantly expressed in breast cancer.  (from OMIM, and NCI)
C21487	RHO-Related_GTP-Binding_Protein_RHOI	RAS_Superfamily_Protein	RAS Homolog Gene Family, Member I Protein|ARHI|ARHI Protein|RAS-Related GTP-Binding Protein Member I Protein|RHO-Related GTP-Binding Protein RHOI	Encoded by human ARHI Gene, the 229-amino acid 26 kD RHO-Related GTP-Binding Protein RHOI (RHO Family) appears to be a tumor suppressor expressed in breast and ovarian epithelial cells, and in heart, liver, pancreas, and brain; expression is absent in breast and ovarian cancer cell lines.  Growth factors decrease expression of RHOI Protein, as does WAF1 (CDKN1A).  The 229 amino acid protein shares 54% amino acid homology with HRAS and 56-62% homology with RAS-related proteins, and contains a highly conserved GTP-binding domain, a putative effector domain distinct from RAS and RAP proteins, and a C-terminal membrane localization motif.  (from SWISS-PROT, OMIM, and NCI)
C21488	Axin-2_Protein	Signaling_Protein	Axin 2|AXIN2|Axil|Axis Inhibitor 2|Conductin	Axin 2 protein is presumed to play an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. The deregulation of beta-catenin is an apparent important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. (from Locus Link)
C21489	Transaminase	Transferase	Transaminase|Aminotransferase|EC 2.6.1	Transaminases are a sub-subclass of mostly pyridoxal phosphate-dependent transferase enzymes that catalyze the transfer of an amino group from a donor (generally an amino acid) to an acceptor (generally a 2-keto acid). Mediating conversion of major intermediate metabolites and reversible transamination, Transaminases are often involved in cellular nitrogen metabolism, amino acid metabolism, gluconeogenesis and in the urea and tricarboxylic acid cycles.
C21490	BRCA1_Associated_Protein-1	Ligand_Binding_Protein	BRCA1 Associated Protein-1|BAP1|Cerebral Protein-13|Cerebral Protein-6|Ubiquitin Carboxy-Terminal Hydrolase	Encoded by the ubiquitously expressed human BAP1 Gene. The 729-amino acid nuclear BRCA1 Associated Protein-1 contains an acidic region, a highly charged C- terminus, and putative nuclear localization signals.  The N-terminus shows homology to ubiquitin C-terminal hydrolases, thiol proteases that catalyze ubiquitin proteolytic processing. BAP1 interacts with the BRCA1 RING finger, but this interaction is prevented by RING finger germline mutations of BRCA1 found in breast cancer kindreds. BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth, acting as a tumor suppressor in the BRCA1 growth control pathway.  (from OMIM)
C21491	Breast_Cancer_Anti-Estrogen_Resistance-1_Protein	Adaptor_Signaling_Protein	Breast Cancer Anti-Estrogen Resistance 1 Protein|BCAR1|BCAR1 Protein|CAS|CRK-Associated Substrate|CRKAS|p130CAS	Encoded by human BCAR1 Gene, conserved ubiquitous 870-amino acid 116 kD cytoplasmic p130CAS (CAS Family) is an adaptor molecule: Ser-region, NH-SH3, central YXXP motif SH2-binding site substrate domain, SRC SH3-binding site COOH Pro-rich binding region, and C-terminal HLH. SH3 localizes CAS to focal adhesions; interacts with FAK1 P-rich region. FAK1 phosphorylates CAS YDYVHL motif. SRCs phosphorylate CAS. CAS SH2-binding sites may bind CRK, NCK, and ABL. CAS HLH may dimerize CASL. CAS Ser region promotes serum response. CAS moves to focal adhesions upon integrin triggered Y-phosphorylation. CAS complexes with CRKL and LYN. CAS functions in cardiovascular development, actin assembly, cell migration, and growth. Over expression confers breast cancer anti-estrogen resistance.  (from SWISS-PROT, OMIM, and NCI)
C21492	Mitotic_Spindle_Checkpoint	Cell_Cycle_Checkpoint	Mitotic/Spindle Checkpoint|Mitosis Checkpoint|Mitotic Checkpoint	The mitotic/spindle checkpoint ensures that all replicated chromatids are properly connected to opposing spindle poles before separation (anaphase) can begin. The proteins responsible for this form a complex on the kinetochores.
C21493	Breast_Cancer_Anti-Estrogen_Resistance-2_Protein	Protein_with_Unknown_or_Unclassified_Function	Breast Cancer Anti-Estrogen Resistance 2 Protein|BCAR2|BCAR2 Protein	Encoded by human BCAR2 Gene, Breast Cancer Anti-Estrogen Resistance 2 Protein is similar to gamma-butyrobetaine 2-oxoglutarate dioxygenase (C. elegans, Drosophila) and likely responsible for development of an anti-estrogen-resistant phenotype.  (from Int J Cancer. 1997; 72:700, LocusLink, GeneCard, and NCI)
C21494	BUB1_Gene	Cell_Cycle_Gene	BUB1 Gene|BUB1|BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog Gene|BUBR1 Gene|MAD3L Gene|hBUB1 Gene	The human BUB1 gene at chromosome 2q14 encodes a 120-kD serine/threonine protein kinase, BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog (Yeast). This protein monitors the attachment of chromosomes to spindle poles and may be a component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. As part of a common complex in checkpoint-activated cells, Bub1 monitors different spindle events compared to BubR1 and integrates different signals into a single signal that is then relayed to the downstream cell cycle machinery. It interacts with Bub3, CENP-F, CENP-E and mitosin. The BUB1 gene is highly expressed in thymus followed by spleen. Defects in Bub1 are associated with tumor formation. (From LocusLink, Swiss_Prot and NCI)
C21495	BUB1_Protein	Serine-Threonine_Protein_Kinase	BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog|BUB1|BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog (Yeast)	BUB1 Budding Uninhibited by Benzimidazoles 1 Homolog (Yeast), encoded by the human BUB1 gene, is a 120-kD serine/threonine protein kinase. This protein monitors the attachment of chromosomes to spindle poles and may be a component of the mitotic checkpoint that delays anaphase until all chromosomes are properly attached to the mitotic spindle. As part of a common complex in checkpoint-activated cells, Bub1 monitors different spindle events compared to BubR1 and integrates different signals into a single signal that is then relayed to the downstream cell cycle machinery. It interacts with Bub3, CENP-F, CENP-E and mitosin. The BUB1 gene is highly expressed in thymus followed by spleen. Defects in Bub1 are associated with tumor formation. (From LocusLink, Swiss_Prot and NCI)
C21496	Breast_Cancer_Anti-Estrogen_Resistance-3_Protein	Protein_with_Unknown_or_Unclassified_Function	Breast Cancer Anti-Estrogen Resistance 3|BCAR3|Breast Cancer Anti-Estrogen Resistance 3 Protein|Novel SH2-Containing Protein 2	Encoded by human BCAR3 Gene, the 92.6 kD 825-amino acid BCAR3 Protein contains a putative SH2 domain, a hallmark of tyrosine kinase signaling molecules, and sequences homologous to CDC48 (Yeast).  Abundant expression is seen in heart, placenta, skeletal muscle, spleen, prostate, testis, ovary, small intestine, colon, fetal kidney, and several cancer cell lines, but not in nonmalignant breast tissue.  NSP2 induces anti-estrogen resistance in estrogen-dependent breast tumors.  (from SWISS-PROT, OMIM, and NCI)
C21497	Breast_Carcinoma_Amplified_Sequence-1_Protein	Protein_with_Unknown_or_Unclassified_Function	Breast Carcinoma Amplified Sequence 1|AIBC1|BCAS1|BCAS1 Protein|NABC1	Encoded by human BCAS1 Gene, the predicted 584-amino acid 62 kD NABC1 Protein has no significant homology to other proteins and has unknown function.  It is over expressed in most but not all breast cancer cell lines in which the gene is amplified and is associated with more aggressive tumor phenotypes.  Although not consistently expressed in breast cancer cell lines, NABC1 is a candidate oncogene product.  (from SWISS-PROT, OMIM, and NCI)
C21498	Breast_Carcinoma_Amplified_Sequence-2_Protein	Protein_with_Unknown_or_Unclassified_Function	Breast Carcinoma Amplified Sequence 2|BCAS2|BCAS2 Protein|DAM1	Encoded by human BCAS2 Gene, the ubiquitous 225-amino acid DAM1 Protein contains a central putative N-glycosylation site and multiple N-terminal putative phosphorylation sites.  A sequence identical to DAM1 is seen in Putative Spliceosome-Associated Protein SPF27.  (from OMIM, and NCI)
C21499	Breast_Carcinoma_Amplified_Sequence-3_Protein	Protein_with_Unknown_or_Unclassified_Function	Breast Carcinoma Amplified Sequence 3|BCAS3|BCAS3 Protein	Encoded by human BCAS3 Gene, 913-amino acid 99.6 kD BCAS3 Protein has an unknown function.  (from SWISS-PROT, LocusLink, and NCI)
C21500	Breast_Carcinoma_Amplified_Sequence-4_Protein	Protein_with_Unknown_or_Unclassified_Function	Breast Carcinoma Amplified Sequence 4|BCAS4|BCAS4 Protein	Encoded by human BCAS4 Gene, 211-amino acid 22.8 kD BCAS4 Protein has an unknown function but high similarity to a region of MAP4K1 and similarity to metalloendopeptidase (Drosophila).  BCAS4 is expressed in brain, heart, liver, pancreas, prostate, kidney, and lung.  (from SWISS-PROT, LocusLink, and NCI)
C21501	BRCD1_Protein	Protein_with_Unknown_or_Unclassified_Function	BRCD1 Protein|BCDS1|BRCD1|Breast Cancer, Ductal, Suppressor-1	Encoded by human BCDS1 Gene, BCDS1 Protein has an unknown function and is associated with breast cancer.  (from LocusLink, OMIM, and NCI)
C21502	BCPR_Protein	Protein_with_Unknown_or_Unclassified_Function	BCPR Protein|BCPR|Breast Cancer-Related Regulator of TP53|Breast Cancer-Related Regulator of TP53 Protein	Encoded by human BCPR Gene, BCPR Protein appears to be associated with expression of p53, perhaps regulating its expression.  Lesions of BCPR seem to be involved in most breast cancers.  (from OMIM and NCI)
C21503	BC-2_Protein	Protein_with_Unknown_or_Unclassified_Function	BC-2 Protein|BC-2|Putative Breast Adenocarcinoma Marker Protein (32kD)	Encoded by human BC-2 Gene, 222-amino acid 32 kD BC-2 Protein has an unknown function and low similarity to Vps24p (S. cerevisiae).  (from SWISS-PROT, LocusLink, and NCI)
C21504	BRCA3_Protein	Protein_with_Unknown_or_Unclassified_Function	BRCA3 Protein|BRCA3|BRCAX Protein|Breast Cancer 3 Protein	Encoded by human BRCA3 Gene, BRCA3 Protein has an unknown function and is associated with breast cancer.  (from LocusLink, OMIM, and NCI)
C21505	Breast_Cancer_Antigen_NY-BR-1_Protein	Protein_with_Unknown_or_Unclassified_Function	Ankyrin Repeat Domain 30A|Breast Cancer Antigen NY-BR-1|NY-BR-1	Encoded by human Breast Cancer Antigen NY-BR-1 Gene expressed in breast and testis, the 1341-amino acid 152 kD NY-BR-1 Protein contains an apparent DNA-binding bZIP motif and five tandem ankyrin repeats, implying a transcription factor involved in protein-protein interactions.  (from Cancer Res 2001; 61:2055, SWISS-PROT, LocusLink, and NCI)
C21506	BRMS1_Protein	Protein_with_Unknown_or_Unclassified_Function	BRMS1 Protein|BRMS1|Breast Cancer Metastasis-Suppressor 1	Encoded by human BRMS1 Gene, the widely expressed 28 kD BRMS1 Protein (BRMS1 Family) contains 246 predicted amino acids.  BRMS1 may mediate metastasis suppression in breast carcinoma; locally invasive tumors that express BRMS1 are significantly less metastatic to lungs and regional lymph nodes.  (from SWISS-PROT, OMIM, and NCI)
C21507	COX7A2L_Protein	Protein_with_Unknown_or_Unclassified_Function	COX7A2L Protein|COX7A-Related Protein|COX7A2L|COX7AR Protein|COX7RP Protein|Cytochrome C Oxidase Subunit VIIA Polypeptide 2 Like Protein|EB1 Protein|Mitochondrial Cytochrome C Oxidase Subunit VIIA-Related Protein	Encoded by human COX7A2L Gene, the ubiquitous 114-amino acid 12.6 kD (precursor) COX7A-Related Protein (COXVIIA Family) is homologous to mouse Sig81 and contains C-terminal residues similar to polypeptides 1 and 2 of cytochrome c oxidase subunit VIIa.  COX7A-Related Protein may be a regulatory subunit of mitochondrial COX and mediate higher energy production in estrogen target cells.  (from SWISS-PROT, OMIM, and NCI)
C21508	RHO-GTPase-Activating_Protein-7	Regulatory_Protein	RHO-GTPase-Activating Protein 7|DLC-1|DLC1|DLC1 Protein|Deleted in Liver Cancer 1 Protein|HP Protein|RHO-Type GTPase-Activating Protein 7|STARD12|START Domain-Containing Protein 12|Star-Related Lipid Transfer Protein 12	Expressed in spleen, prostate, testis, ovary, small intestine and colon by human DLC1 Gene, cytoplasmic 1091-aa 123-kD RHO-GTPase-Activating Protein 7 is a RHO-specific GTPase-activating protein and activator of PLCD1 that contains a Rho-Gap domain, a Sam domain, and a Start domain and may induce morphological changes and detachment through cytoskeletal reorganization. (NCI)
C21510	C22orf19_Gene	Gene_with_Unknown_or_Unclassified_Function	C22orf19 Gene|C22orf19|Chromosome 22 Open Reading Frame 19|Chromosome 22 Open Reading Frame 19 Gene|Fmip|KIAA0983|PK1.3	Identified as a novel Fms-interacting protein. Overexpression in a bipotential myeloid progenitor cell line prevented M-CSF induced macrophage differentiation. Instead, cells differentiated into granulocytes.  Thus, appears to have an effect on lineage commitment. (from Oncogene 1999;18:6488-95)
C21511	Epithelial_Stromal_Interaction-1_Protein	Protein_with_Unknown_or_Unclassified_Function	Epithelial Stromal Interaction 1|BRESI1 Protein|EPSTI1|Epithelial Stromal Interaction 1 Protein	Encoded by human EPSTI1 Gene and expressed in prostate, kidney, and lung, EPSTI1 Protein may function in epithelial stromal interaction. EPSTI1 is similar to G-protein coupled receptor family 1 (C. elegans) and G-protein coupled receptor protein signaling pathway growth hormone-releasing hormone receptor (Drosophila).  (from GeneCard, LocusLink and NCI)
C21512	FBXW7_Protein	Protein_Complex_Subunit	FBXW7 Protein|AGO Protein|Archipelago Homologue Protein|F-box and WD-40 domain protein 7|F-box protein FBW7|FBXW7	Encoded by human FBXW7 Gene, alpha and beta AGO Protein (F-Box Family), 707 and 627 amino acids respectively, differ in their N-termini and contain the putative functional F box and seven WD repeats.  F-box proteins constitute one of four SCF subunits of the ubiquitin protein ligase complex, involved in phosphorylation-dependent ubiquitination.  AGO protein binds to cyclin E, and probably targets it for ubiquitin-mediated degradation.  AGO mutant cells have elevated levels of cyclin E without increased cyclin E mRNA levels.  Homologue of Cdc4 (S. cerevisiae) and Archipelago (Drosophila), human AGO also has low similarity to Met30p (S. cerevisiae).  Drosophila and human AGO are 78% identical.  AGO may represent a mutational target in ovarian cancer.  (from OMIM and NCI)
C21513	GAGED3_Protein	Protein_with_Unknown_or_Unclassified_Function	GAGED3 Protein|G Antigen Family D, Protein 3|GAGED3|XAGE-2 Protein|XAGE-3 Protein|XAGE3 Protein	Expressed in testis and placenta by human GAGED3 Gene (GAGE Family, CT Family), 111-aa 12-kD XAGE3 Protein has unknown function and shares similarity with GAGE/PAGE proteins, as well as with Pyridoxal-Dependent Decarboxylase Conserved Domain (C. elegans) and Larval Locomotory Behavior Glutamate Decarboxylase (Drosophila). (NCI)
C21514	Temporal_Modifier	Qualifier	Temporal Qualifier
C21515	NF2-Meningioma_Region_Protein-pK1-3	Protein_with_Unknown_or_Unclassified_Function	Chromosome 22 Open Reading Frame 19|C22orf19	Identified as a novel Fms-interacting protein. Overexpression in a bipotential myeloid progenitor cell line prevented M-CSF induced macrophage differentiation. Instead, cells differentiated into granulocytes.  Thus, appears to have an effect on lineage commitment. (from Oncogene 1999;18:6488-95)
C21516	Glutaminase	Hydrolase	Glutaminase|Breast Cell Glutaminase|EC 3.5.1.2|GA|GA Protein|GLS2|Liver Glutaminase	Encoded by human GA Gene, the 602-amino acid 66 kD (precursor) Glutaminase (GA Family) has a putative N-terminal mitochondrial import presequence.  Expressed in liver, brain, and pancreas, but not in kidney, heart, skeletal muscle, lung, or placenta, GA protein shares 94% and 72% sequence identity with rat liver and kidney glutaminases, respectively.  Containing two ankyrin repeats, human glutaminase is most similar to rat liver-type glutaminase, but is not liver specific.  Involved in regulation of glutamine catabolism, mitochondrial glutaminase converts L-glutamine to L-glutamate and NH3.  Glutaminase expression and activity depend on the cell proliferation state with highest levels at the beginning of the exponential growth phase. (NCI)
C21517	Calcium-Activated_Chloride_Channel-2	Ion_Channel_Protein	Calcium-Activated Chloride Channel-2|CLCA2|Calcium-Sensitive Chloride Channel 2|Chloride Channel, Calcium Activated, Family Member 2 Protein	Encoded by human CLCA2 Gene (similar to CLCA1), the 943-amino acid Calcium-Activated Chloride Channel-2 (CLCA Family) is expressed in trachea, lung, and mammary gland and displays outward rectifying anion conductance. Family members differ in tissue distribution. CLCA2 protein contains a large N-terminal extracellular domain containing conserved cysteines, five transmembrane domains, a monobasic proteolytic cleavage consensus site, potential glycosylation sites, and potential PKC phosphorylation sites. Nascent CLCA2 may be cleaved into 86 kD N-terminal, and 34 kD C-terminal, polypeptides associated with the cell surface. CLCA2 may play a role in the pathogenesis of cystic fibrosis and in cancer metastasis to the lung, mediating vascular arrest and colonization. CLCA2 has been implicated as a tumor suppressor for breast cancer.  (from SWISS-PROT, OMIM, and NCI)
C21518	Complement_Component_Gene	Gene	Complement Component Gene	These genes encode more than 30 proteins of the complement system engaged in host defense. This system provides both an independent immune system capable of attacking microbes as well as other foreign material and an adjunct to the antibody system. Once activated, the complement system fires in a cascade-like fashion in which one component activates the next. Both swift and powerful, millions of complement components can deposit on an invading microbe within only a few minutes. Such a potent system requires strict regulation to avoid host injury. Membrane cofactor protein (MCP) is one critical regulator aimed at controlling inadvertent complement activation on host cells and nearly every cell examined expresses MCP on its cell membrane. (http://research.medicine.wustl.edu)
C21519	Complement_Activation	Biochemical_Process	Complement Activation	The complement system consists of more than 30 proteins engaged in host defense. It provides both an independent immune system capable of attacking microbes as well as other foreign material and an adjunct to the antibody system. Once activated, the complement system fires in a cascade-like fashion in which one component activates the next. Both swift and powerful, millions of complement components can deposit on an invading microbe within only a few minutes. Such a potent system requires strict regulation to avoid host injury. Membrane cofactor protein (MCP) is one critical regulator aimed at controlling inadvertent complement activation on host cells and nearly every cell examined expresses MCP on its cell membrane.
C21520	Hypoxia_Up-Regulated-1_Protein	Stress-Induced_Protein	Hypoxia Up-Regulated 1 Protein|150 kD Oxygen-Regulated Protein|HYOU1|ORP150 Protein|Oxygen Regulated Protein (150kD)	Highly expressed in secretory tissues (liver and pancreas) by human HYOU1 Gene (HSP70 Family), hypoxia-induced 999-aa (precursor) 150 kD Hypoxia Up-Regulated 1 Protein is an endoplasmic reticulum cytoprotectant in oxygen deprivation that may act as a chaperone with GRPs and participate in protein folding and secretion. ORP150 contains a C-terminal KNDEL sequence and N-terminal similarity to HSP70 ATPase domain. ORP150 suppression is associated with accelerated apoptosis. ORP150 expression in neurons suppresses caspase-3-like activity and enhances BDNF under hypoxia signaling. Elimination of the signal peptide through an alternative translation site may generate a cytosolic housekeeping protein. (NCI)
C21521	C3_Gene	Complement_Component_Gene	C3 Gene|C3|Complement Component 3 Gene	The C3 gene at chromosome 19p13.3-p13.2 encodes Complement Component 3, which plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacteria infection. (From LocusLink)
C21522	Host_Defense	Host_Defense_Mechanism	Host Defense	Host Defenses against pathology include physical barriers to pathogens, immediate nonspecific and constitutive (innate) defenses, specific inducible immune responses, metabolic and physiologic homeostatic mechanisms, detoxification, repair processes, and healing mechanisms.
C21523	Complement_Component_Protein	Protein_Organized_by_Function	Complement Component Protein	Any of the serum proteins that interact with antigen antibody complex to produce cytolytic, chemotaxic, anaphylactic, and other effects. (from CSP2000)
C21524	Interleukin-24	Interleukin	Interleukin-24|IL24|MDA7 Protein|Melanoma Differentiation Associated Protein 7|ST16 Protein|Suppression of Tumorigenicity 16 Protein	Encoded by human IL24 Gene, secreted Interleukin 24 Protein (IL10 Family) consists of 206 amino acids with a predicted size of 23.8 kD (precursor).  IL24 appears to represent a differentiation-, growth-, and apoptosis-associated protein.  It is growth inhibitory toward diverse tumor cells and may contribute to terminal cell differentiation.  The protein selectively induces p53-independent apoptosis in breast carcinoma cells and inhibits tumor growth in nude mice.  IL24 is a negative regulator of progression in human melanoma cells induced to terminally differentiate.  (from SWISS-PROT, OMIM, and NCI)
C21525	MLN51_Protein	Cytoplasmic_Protein	MLN51 Protein|CASC3|MLN51|Metastatic Lymph Node 51 Protein	Encoded by human MLN51 Gene, ubiquitous cytoplasmic 76.3 kD MLN51 Protein contains 703 residues that share no significant homology with any known protein.  MLN51 is well conserved between vertebrate and invertebrate species suggesting an important function.  The N-terminal half contains putative nuclear localization signals and a coiled-coil domain that seems to promote MLN51 oligomerization.  The C-terminal half contains a SH2 and four SH3 binding motifs and may regulate nuclear localization.  The unusual combination of protein-protein interaction domains in MLN51 suggests a possible nucleo-cytoplasmic function.  Malignant breast carcinoma epithelial cells exhibit over expression of MLN51.  (from Oncogene 2002; 21:4422, SWISS-PROT, LocusLink, and NCI)
C21526	NY-BR-20_Protein	Protein_with_Unknown_or_Unclassified_Function	Calmodulin-Like 4 Protein|Breast Cancer Antigen NY-BR-20 Protein|CALML4|Calmodulin-Like 4|NY-BR-20|NY-BR-20 Protein	Encoded by human NY-BR-20 Gene, NY-BR-20 Protein has an unknown function.  (from SWISS-PROT, LocusLink, and NCI)
C21527	Complement_Component-3	Complement_Component_Protein	Complement Component 3|C3	Complement Component 3, encoded by the C3 gene plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacteria infection. (From LocusLink)
C21528	NY-BR-84_Protein	Protein_with_Unknown_or_Unclassified_Function	Serologically Defined Breast Cancer Antigen 84|Breast Cancer Antigen 84 NY-BR-84 Protein|Hypothetical 43.2 kD Protein|NY-BR-84|SDBCAG84	Encoded by human NY-BR-84 Gene, the widely expressed 383-amino acid 43 kD NY-BR-84 Protein has an unknown function and sequence similarity to acyl-CoA thioesterase (C. elegans) and serologically defined breast cancer antigen 84 (Mouse).  (from SWISS-PROT, LocusLink, and NCI)
C21529	OBTP_Protein	Protein_with_Unknown_or_Unclassified_Function	OBTP Protein|C6orf49|Over-Expressed Breast Tumor Protein	Encoded by human OBTP Gene, 74-amino acid 8 kD Over-Expressed Breast Tumor Protein contains two LIM domains and may mediate protein-protein interactions.  (from SWISS-PROT, and NCI)
C21530	PHEMX_Protein	Protein_with_Unknown_or_Unclassified_Function|Transmembrane_Protein	PHEMX Protein|PHEMX|Pan-Hematopoietic Expression Protein|TSSC6|Tetraspanin|Tumor-Suppressing STF 6 Protein	Encoded by human PHEMX Gene, 320-amino acid 34.6 kD ubiquitous TSSC6 Protein (Tetraspanin Family) is an integral membrane protein of 290 amino acids that shows no similarity to any reported protein and may play a role in hematopoietic cell function.  High levels of expression are confined to hematopoietic tissues including peripheral blood leukocytes, thymus, and spleen.  Alterations in TSSC6 Protein or its gene may be associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, as well as lung, ovarian, and breast cancer.  (from SWISS-PROT, OMIM, and NCI)
C21531	RBBP1L1_Protein	Ligand_Binding_Protein	RBBP1L1 Protein|BCAA|BCAA Protein|BRCAA1 Protein|Breast Cancer-Associated Antigen BRCAA1|Breast Carcinoma-Associated Antigen BCAA|KIAA0117 Protein|RBP1-Like Protein|Rb-Binding Protein Homolog|Retinoblastoma-Binding Protein 1-Like 1	Encoded by human RBBP1L1 Gene, 803-amino acid 91 kD RBP1-Like Protein is similar to RBP1, containing a Tudor domain and an ARID DNA binding domain.  Different protein isoforms are thought to exist, but all have not been fully determined.  Variant 2 encodes a shortened isoform 2 that lacks an internal protein fragment.  (from SWISS-PROT, LocusLink, and NCI)
C21532	Small_Breast_Epithelial_Mucin	Mucin	Small Breast Epithelial Mucin|LOC118430|SBEM Protein	Encoded by human Small Breast Epithelial Mucin Gene, 90-amino acid 9 kD Small Breast Epithelial Mucin is a putative low molecular weight secreted sialoglycoprotein expressed only in mammary and salivary glands.  (from Cancer Res 2002; 62:2736, SWISS-PROT, LocusLink, and NCI)
C21533	TACC2_Protein	Retired_Concepts	TACC2 Protein
C21534	TRAF4_Protein	Retired_Concepts	TRAF4 Protein
C21535	TSSC4_Protein	Protein_with_Unknown_or_Unclassified_Function	TSSC4 Protein|TSSC4|Tumor Suppressing STF 4 Protein	Encoded by human TSSC4 Gene, the 329-amino acid 34 kD TSSC4 Protein shows no close similarity to previously reported proteins and is expressed in fetal brain, lung, liver, and kidney.  Alterations in TSSC4 may be associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, as well as lung, ovarian, and breast cancer.  (from SWISS-PROT, OMIM, and NCI)
C21536	WFDC1_Protein	Extracellular_Protein	WFDC1 Protein|Prostate Stromal Protein ps20|WAP Four-Disulfide Core Domain 1 Protein|WFDC1	Encoded by human WFDC1 Gene, the 220-amino acid 24 kD (precursor) secretory Prostate Stromal Protein ps20 (WAP Family) is a growth inhibitor that contains a WAP four-disulfide core domain characteristic of protease inhibitors.  The WAP signature motif contains eight cysteines forming four disulfide bonds at the core of proteins that functions as a protease inhibitor in many family members.  Human ps20 shares approximately 86% and 88% identity with the rat and mouse secreted growth inhibitor proteins.  Loss of ps20 is associated with prostate, breast, and hepatocellular cancers and Wilms' tumor.  (from SWISS-PROT, OMIM, Proteome, and NCI)
C21537	WNT4_Protein	WNT_Family_Protein	WNT4 Protein|WNT4|Wingless-Type MMTV Integration Site Family Member 4 Protein	Encoded by human WNT4 Gene, 351-amino acid 39 kD (precursor) WNT4 Protein (WNT Family) is a putative secreted paracrine cysteine-rich glycoprotein ligand for a seven transmembrane frizzled receptor influencing sex-determination. WNT family signaling proteins regulate cell fate and patterning during embryogenesis. WNT4 is similar to mouse and rat proteins Wnt4, Wnt5a, Wnt5b, Wnt6, Wnt7a, and Wnt7b, which contain 83 conserved amino acid residues, including 21 cysteines. Wnt4 is detected in brain, lung, and kidney mesenchyme. Wnt4 appears to be an autoinducer of nephric mesenchyme-to-epithelial transition. WNT4 up regulates DAX1 (antagonizes SRY) controlling female development and preventing testes formation. WNT4, WNT2, and WNT7B may be associated with abnormal proliferation in breast tissue. (from SWISS-PROT, OMIM, and NCI)
C21538	C5_Gene	Complement_Component_Gene	C5 Gene|C5|Complement Component 5 Gene	Human C5 Gene encodes 1676-aa 19-kDa (precursor) Complement Component 5, a precursor protein containing 1 anaphylatoxin-like domain and 1 NTR domain and similar to C3, C4, and Alpha-2-Macroglobulin. By removal of 4 basic residues, C5 is processed to disulfide linked alpha and beta chains. C5 convertase cleaves the alpha chain, releasing C5a anaphylatoxin and generating C5b. C5 convertase activation of C5 initiates assembly of C5-C9 late complement components into a membrane attack complex; C5b-C6 complex is the assembly foundation of the lytic complex. C5a stimulates chemokinesis and chemotaxis of polymorphonuclear leukocytes to inflammation sites. C5 anaphylatoxin mediates local inflammatory processes; smooth muscle contraction, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. (NCI)
C21539	Complement_Component-5	Complement_Component_Protein	Complement Component 5|C5|Complement C5	Encoded by human C5 Gene, Complement Component 5 is a precursor protein containing 1 anaphylatoxin-like domain and 1 NTR domain and similar to C3, C4, and Alpha-2-Macroglobulin. By removal of 4 basic residues, C5 is processed to disulfide linked alpha and beta chains. C5 convertase cleaves the alpha chain, releasing C5a anaphylatoxin and generating C5b. C5 convertase activation of C5 initiates assembly of C5-C9 late complement components into a membrane attack complex; C5b-C6 complex is the assembly foundation of the lytic complex. C5a stimulates chemokinesis and chemotaxis of polymorphonuclear leukocytes to inflammation sites. C5 anaphylatoxin mediates local inflammatory processes; smooth muscle contraction, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. (NCI)
C21540	CALM1_Gene	Ligand_Binding_Protein_Gene	CALM1 Gene|CALM Gene|CALM1|CAM Gene|CAM1 Gene|CAMI Gene|Calmodulin 1 (Phosphorylase Kinase, Delta) Gene|Calmodulin 1 Gene|DD132 Gene|PHKD Gene	The CALM1 gene at chromosome 14q24-q31 encodes Calmodulin 1. Calmodulin 1 is the archetype of the family of calcium-modulated proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin 1 binds calcium and regulates proteins and enzymes in a calcium-dependent manner. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Ubiquitination strongly decreases its activity. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters. (From LocusLink, Swiss_Prot)
C21541	Healthcare_Facility	Sites_of_Care_Delivery	Healthcare Facility|Health Care Facility|INST|Institution	The buildings and organizations where healthcare services are provided.
C21542	Meiotic_Recombination	Recombination	Meiotic Recombination	Extensive Meiotic Recombination occurs during meiosis when the cell performs a round of DNA replication (meiS) followed by homolog synapsis and recombination that involves breakage of chromosomes or DNA molecules and rejoining of fragments in new combinations.
C21543	RAD54-Like_Protein	DNA_Repair_Protein	RAD54-Like Protein|DNA Repair Protein RAD54-Like|HR54|RAD54 Homolog|RAD54L|hHR54|hRAD54	RAD54-Like Protein (RAD54L), encoded by the RAD54L gene, belongs to the DEAD-like helicase superfamily. RAD54L plays a role in homologous recombination related repair of DNA double-strand breaks. The binding of RAD54L to double-strand DNA induces a DNA topological change, which facilitates homologous DNA paring and stimulates DNA recombination. (From LocusLink)
C21544	TRF1-Interacting_Nuclear_Protein-2	DNA_Repair_Protein	TRF1-Interacting Nuclear Protein 2|TERF1 (TRF1)-Interacting Nuclear Factor 2|TIN2|TINF2	TERF1 (TRF1)-Interacting Nuclear Factor 2 (TINF2), encoded by the TINF2 gene, is a 50-kD telomere-associated protein. TINF2 regulates telomere length and prevents excessive telomere elongation. TINF2 binds telomeric DNA-binding-protein (TRF1) and is an essential mediator of TRF1 function. Three isoforms, 1, 2, and 3, may be produced by alternative splicing. TINF2 is detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. (From Swiss_Prot, LocusLink)
C21545	DNA_Topoisomerase-II_Binding_Protein	DNA_Repair_Protein	DNA Topoisomerase II Binding Protein|Hypothetical Protein KIAA0259|KIAA0259|TOPBP1|Topoisomerase (DNA) II Binding Protein	Topoisomerase (DNA) II Binding Protein (TOPBP1), encoded by the TopBP1 gene, is a 173-kD binding protein that interacts with the C-terminal region of topoisomerase II beta. TOPBP1 may stimulate catalytic activity of topoisomerase II beta through transient breakages of DNA strands. (From LocusLink)
C21546	Three_Prime-Five_Prime_Exonuclease	Exonuclease	3'-5' Exonuclease	Three Prime-Five Prime Exonucleases prefer mismatched 3-prime termini, catalyze nucleoside monophosphate excision from 3-prime DNA termini and may be a DNA polymerase III subunit, which does not have intrinsic exonuclease activity. 3-prime terminal nucleotide excision from DNA is required to generate termini for subsequent DNA metabolic pathways.
C21547	Three_Prime_Repair_Exonuclease-1	DNA_Repair_Protein	Three Prime Repair Exonuclease 1|3 Prime Repair Exonuclease 1|ATR Interacting Protein|ATR-Interacting Protein|ATRIP|DKFZp434J0310|DNase III|DRN3|Deoxyribonuclease III, DnaQ/MutD (E. coli)-Like|FLJ12343|TREX1	TREX1 protein is phosphorylated by Ataxia Telangiectasia and Rad3 Related Protein (ATR), regulates ATR expression, and is an essential component of the DNA damage checkpoint pathway. TREX1 and ATR are mutually dependent partners in cell cycle checkpoint signaling pathways. The downstream ORF encodes isozymes that contain 3-prime-to-5-prime exonuclease activity and the excision of nucleotides from DNA 3-prime termini are required by DNA replication, repair, and recombination. They remove mismatched, modified, fragmented, and normal nucleotides to generate the appropriate 3-prime termini for subsequent steps in the DNA metabolic pathways. (NCI)
C21548	Telomere_Shortening	DNA_Sequence_Alteration	Telomere Shortening	Telomere Shortening occurs every time linear eukaryotic chromosomes are replicated due to premature stoppage of the DNA polymerase complex in the highly repetitive telomere DNA region several hundred bases before the end of a chromosome.
C21549	OSM_Gene	Cytokine_Gene	OSM Gene|MGC20461|OSM|Oncostatin M Gene	Human OSM Gene (IL6/LIF/OSM Family) encodes 252-aa 28-kDa (precursor) secreted glycoprotein cytokine Oncostatin M, a growth regulator that inhibits proliferation of some cells and regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. (NCI)
C21550	Cytokine_Gene	Gene	Cytokine Gene	Cytokines are soluble glycoproteins released by cells of the immune system, which act nonenzymatically through specific receptors to regulate immune responses. Cytokines resemble hormones in that they act at low concentrations and bind with high affinity to a specific receptor. (Health On the Net Allergy Glossary; http://www.hon.ch/Library/Theme/Allergy/Glossary/allergy.html)
C21551	FLT3LG_Gene	Colony-Stimulating_Factor_Gene	FLT3LG Gene|FLT3LG|FMS-Related Tyrosine Kinase 3 Ligand Gene	Human FLT3LG Gene at 19q13.3 encodes 2 alternative isoforms of 26-kDa (precursor) FLT3 Ligand, a novel hematopoietic growth factor ligand for the FLT3 tyrosine kinase receptor: 235-aa type I membrane protein (isoform 1) and 178-aa homodimeric secreted (isoform 2). Synergizing with other colony stimulating factors and interleukins, FLT3LG stimulates proliferation of hematopoietic progenitor cells. (NCI)
C21552	Three_Prime_Repair_Exonuclease_2	DNA_Repair_Protein	Three Prime Repair Exonuclease 2|26S Proteasome-Associated UCH Interacting Protein 1|3'-5' Exonuclease TREX2|TREX2|Three Prime Repair Exonuclease 2 Isoform UIP1|UIP1|XQ28ORF	Encoded as alternative isoforms by TREX2 Gene, Three Prime Repair Exonuclease 2 contains 3 conserved exonuclease motifs and catalyzes nucleoside monophosphate excision from 3-prime DNA termini and may be a subunit of DNA polymerase III. 26S Proteasome-Associated UCH Interacting Protein 1 results from use of a different open reading frame of TREX2 Gene, producing a protein structurally unrelated to the other isoforms that interacts with Ubiquitin C-Terminal Hydrolase 37, which may edit polyubiquitin chains on ubiquitinated substrates. Ubiquitin C-Terminal Hydrolases (UCH) hydrolyze C-terminal esters and amides of ubiquitin to generate free monomeric ubiquitin from ubiquitin proproteins, but do not deubiquitinate ubiquitin-protein conjugates or disassemble polyubiquitin chains. (NCI)
C21553	TNFRSF1B_Gene	TNF_Receptor_Family_Gene	TNFRSF1B Gene|CD120b|P75TNFR|TBPII|TNF-R-II|TNF-R75|TNFBR|TNFR2|TNFR80|TNFRSF1B|Tumor Necrosis Factor Receptor Superfamily, Member 1B Gene	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is required for CD40 and TNF-mediated activation of NF-kappa B and programmed cell death. This protein and TNF-receptor 1 form a heterocomplex that mediates the recruitment of two anti-apoptotic proteins, baculoviral IAP repeat-containing protein 1 (BIRC1/c-IAP1) and 2 (BIRC2/c-IAP2). BIRC1 has been shown to act as a ubiquitin ligase that induces the ubiquitination and degradation of this receptor, which may potentiate TNF-induced apoptosis. Knockout studies in mice suggested a role of this protein in protecting neurons from apoptosis by stimulating antioxidative pathways. (LocusLink)
C21554	TNFRSF1A_Gene	TNF_Receptor_Family_Gene	TNFRSF1A Gene|CD120a|FPF|MGC19588|TBP1|TNF-R|TNF-R-I|TNF-R55|TNFAR|TNFR1|TNFR55|TNFR60|TNFRSF1A|Tumor Necrosis Factor Receptor Superfamily, Member 1A Gene|p55-R	The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is one of the major receptors for the tumor necrosis factor-alpha. This receptor can activate NF-kappaB, mediate apoptosis, and function as a regulator of inflammation. Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. Germline mutations of the extracellular domains of this receptor were found to be associated with the autosomal dominant periodic fever syndrome. The impaired receptor clearance is thought to be a mechanism of the disease. (LocusLink)
C21555	TNFRSF6_Gene	TNF_Receptor_Family_Gene	FADD Gene|APO-1|APT1|CD95|FADD|FAS|FASTM|TNFRSF6|TNFRSF6 Gene	TNFRSF6 gene product plays a central role in the physiological regulation of programmed cell death, and is implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this protein receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor also activates NF-kappa B, MAPK3/ERK1, and MAPK8/JNK, and is involved in transducing the proliferating signals in normal diploid fibroblast and T cells. At least eight alternatively spliced transcript variants encoding seven distinct isoforms have been described. The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full-length isoform. (LocusLink)
C21556	Deubiquitination	Post-Translational_Modification	Deubiquitination	The generation of ubiquitin from proproteins and the processing of polyubiquitin chains to release monomeric ubiquitin. (NCI)
C21557	Deubiquitinating_Enzyme	Hydrolase	Deubiquitinating Enzyme	Deubiquitinating Enzymes are hydrolases that catalyze cleavage of ubiquitinated substrates with addition of H2O at the point of cleavage. Protein ubiquitination regulates the half-lives of many proteins by targeting them for degradation. Ubiquitination and deubiquitination enzymes participate in highly regulated protein degradation, chromatin remodeling, heat shock, cell cycle progression, differentiation, antigen presentation, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis.
C21558	Ubiquitin_C-Terminal_Hydrolase	Deubiquitinating_Enzyme	Ubiquitin C-Terminal Hydrolase|UCH	The Ubiquitin C-Terminal Hydrolases (UCH) are deubiquitinating enzymes which hydrolyze carboxyl-terminal esters and amides of ubiquitin to generate free monomeric ubiquitin from ubiquitin proproteins, but not to deubiquitinate ubiquitin-protein conjugates or disassemble polyubiquitin chains. The expression of these enzymes is tissue-specific and developmentally regulated.  Members of this deubiquitinating family are also important modulators of cellular function. (NCI)
C21559	TNFRSF10A_Gene	TNF_Receptor_Family_Gene	TNFRSF10A Gene|APO2|DR4|MGC9365|TNFRSF10A|TRAILR-1|TRAILR1|Tumor Necrosis Factor Receptor Superfamily, Member 10A Gene	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. (LocusLink)
C21560	Three_Prime_Repair_Exonuclease-2	Retired_Concepts	26S Proteasome-Associated UCH Interacting Protein 1|TREX2|Three Prime Repair Exonuclease 2 Isoform UIP1|UIP1|XQ28ORF	Alternative splicing of the TREX2 gene results in five transcript variants.  26S Proteasome-Associated UCH Interacting Protein 1 results from use of a different open reading frame, producing a protein structurally unrelated to the other isoforms of Three Prime Repair Exonuclease 2 also encoded by the same gene. This protein interacts with ubiquitin C-terminal hydrolase 37, which may edit polyubiquitin chains on ubiquitinated substrates. The physiological role of Ubiquitin C-terminal Hydrolases (UCH) is to hydrolyze C-terminal esters and amides of ubiquitin and to generate free monomeric ubiquitin from ubiquitin proproteins, but not to deubiquitinate ubiquitin-protein conjugates or disassemble polyubiquitin chains. (From PubMed and NCI)
C21561	TNFRSF10B_Gene	TNF_Receptor_Family_Gene	TNFRSF10B Gene|DR5|KILLER|KILLER/DR5|TNFRSF10B|TRAILR2|TRICK2|TRICK2A|TRICK2B|TRICKB|Tumor Necrosis Factor Receptor Superfamily, Member 10B Gene|ZTNFR9	The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. (LocusLink)
C21562	EPOR_Gene	Cytokine_Receptor_Gene	EPOR Gene|EPOR|Erythropoietin Receptor Gene	The EPOR gene encodes Erythropoietin Receptor, which is a member of the cytokine receptor family. Upon erythropoietin binding, the erythropoietin receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. (from LocusLink)
C21563	IL2RA_Gene	Cytokine_Receptor_Gene	IL2RA Gene|CD25|IL2R|IL2RA|Interleukin 2 Receptor, Alpha Gene|TCGFR	The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolysis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. (LocusLink)
C21564	Xeroderma_Pigmentosum_Complementation_Group-A_Protein	DNA_Repair_Protein	Xeroderma Pigmentosum Complementation Group A Protein|XPA|Xeroderma Pigmentosum Group A Complementing Protein	DNA-Repair Protein Complementing XP-A Cells (XPA), the nuclear protein encoded by the XPA gene, has a zinc finger domain and is involved in the DNA excision repair pathway. XPA initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. XPA complements the defect in xeroderma pigmentosum (XP) group A (XP-A), an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders.
C21565	X-Ray_Repair_Cross_Complementing_Protein-1	DNA_Repair_Protein	X-Ray Repair Cross Complementing Protein 1|DNA Repair Protein XRCC1|RCC|X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 1|X-Ray-Repair, Complementing Defective, Repair In Chinese Hamster|XRCC1	X-Ray Repair Cross Complementing Protein 1 (XRCC1), encoded by the XRCC1 gene, functions in the repair of single-strand DNA breaks and sister chromatid exchange. With no catalytic activity, XRCC1 is required to interact with polynucleotide kinase (PNK) and poly(ADP-ribose) polymerase, linking DNA polymerase-beta and DNA ligase III (LIG3) with single-strand break repair and short-patch base excision repair, respectively, after treatment with ionizing radiation and alkylating agents. In the initial step of processing damaged DNA ends, XRCC1 stimulates the DNA kinase and DNA phosphatase activities of PNK at damaged DNA termini, thus accelerating the overall repair reaction in mammalian single-strand break repair pathway. XRCC1 is also required for full activity of LIG3 in rejoining of broken DNA strands. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity.
C21566	Single_Strand_Break_Repair	DNA_Repair	Single Strand Break Repair|Single-Strand Break Repair	Single Strand Break Repair mechanisms repair breaks that occur on one DNA strand.
C21567	X-Ray_Repair_Cross_Complementing_Protein-2	DNA_Repair_Protein	X-Ray Repair Cross Complementing Protein 2|DNA Repair Protein XRCC2|X-Ray Repair, Complementing Defective, Repair In Chinese Hamster|XRCC2	X-Ray Repair Cross Complementing Protein 2, encoded by the XRCC2 gene, is a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC2 is essential for the efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. XRCC2 also may have a role in meiosis. (from OMIM 600375, LocusLink 7516 and NCI)
C21568	CD209_Gene	Cell_Adhesion_Molecule_Gene	CD209 Gene|CD209|CDSIGN|DC-SIGN|DC-SIGN1	The CD209 gene encodes CD209 Antigen, which binds ICAM3 with high affinity. CD209 Antigen is a type II transmembrane protein consisting of 404 amino acids with 3 distinct domains. The 40-amino acid N-terminal cytoplasmic domain is separated by a hydrophobic stretch of 15 amino acids from a region consisting of 1 incomplete and 7 complete tandem repeats of nearly identical sequence. The extracellular C-terminal region (cys253 to ala404) shows homology to C-type lectins. Sequence analysis reveals that CD209 antigen is identical to the HIV-1 gp120-binding protein. CD209 antigen, which is abundantly expressed by dendritic cells (DCs) both in vitro and in vivo, mediates transient adhesion with T cells. Since antibodies against CD209 antigen inhibited DC-induced proliferation of resting T cells, these findings predicted that CD209 antigen enables T-cell receptor engagement by stabilization of the DC/T-cell contact zone.(OMIM)
C21569	X-Ray_Repair_Cross_Complementing_Protein-3	DNA_Repair_Protein	X-Ray Repair Cross Complementing Protein 3|DNA Repair Protein XRCC3|X-Ray-Repair, Complementing Defective, Repair In Chinese Hamster|XRCC3	X-Ray Repair Cross Complementing Protein 3 (XRCC3), encoded by the XRCC3 gene, is a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. XRCC3 interacts directly with RAD51 and may cooperate with RAD51 during recombinational repair. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity and exposure to UV radiation is a major risk factor for the development of malignant melanoma. DNA damage caused by UV radiation is thought to play a major role in carcinogenesis. The association between polymorphisms in DNA repair genes and the development of malignant melanoma, a T allele at position 18067 in exon 7 of the XRCC3 gene is significantly associated with melanoma development. (from OMIM 600675, LocusLink 7517 and NCI)
C21570	X-Ray_Repair_Cross_Complementing_Protein-4	DNA_Repair_Protein	X-Ray Repair Cross Complementing Protein 4|DNA Double-Strand Break Repair and V(D)J Recombination Protein XRCC4|DNA Repair Protein XRCC4|X-Ray Repair, Complementing Defective, Repair In Chinese Hamster|XRCC4	X-Ray Repair Cross Complementing Protein 4, encoded by the XRCC4 gene, functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. XRCC4 functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. XRCC4 is a ubiquitously expressed protein. Alternative transcription initiation and alternative splicing generates several transcript variants and two protein isoforms. (NCI)
C21571	RARA_Gene	Nuclear_Receptor_Gene	RARA Gene|NR1B1|RAR|RARA|Retinoic Acid Receptor Alpha Gene	Retinoic acid receptor alpha; binds retinoic acid and stimulates transcription in a ligand-dependent manner. (LOcusLink)
C21572	Peptide_Transport	Transport_Process	Peptide Transport	Peptide Transport involves mechanisms that promote the translocation of a peptide from one location to another.
C21573	TAP1_Gene	Transport_Protein_Gene	TAP1 Gene|ABC17|ABCB2|APT1|D6S114E|PSF1|RING4|TAP1|Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP) Gene	The TAP1 gene encodes Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP), which is a member of the superfamily of ATP-binding cassette (ABC) transporters. Being a member of the MDR/TAP subfamily and a subunit of the heterodimeric TAP1/TAP2 complex (TAP), this protein is involved in antigen processing. TAP transports peptides from the cytoplasm to the endoplasmic reticulum for assembly of MHC class I molecules. Loss of TAP function occurs more often in metastatic than in primary tumors. Loss of TAP1 expression may enhance tumor growth by enabling them to escape T-cell recognition during the effector phase of an antitumor immune response in immunized mice. However, it does not change the immunogenicity of tumor cells in the priming phase. Mutations in the TAP1 gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. (From LocusLink 6890, PMID 12019164 and NCI)
C21574	ABC_Transporter-MHC1	ABC_Transporter	Transporter 1, ATP-Binding Cassette, Sub-Family B|ABC Transporter, MHC 1|ATP-Binding Cassette, Sub-Family B, Member 2|Antigen Peptide Transporter 1|Peptide Supply Factor 1|TAP1	Transporter 1, ATP-Binding Cassette, Sub-Family B (MDR/TAP), encoded by the TAP1 gene, is a member of the superfamily of ATP-binding cassette (ABC) transporters. Being a member of the MDR/TAP subfamily and a subunit of the heterodimeric TAP1/TAP2 complex (TAP), this protein is involved in antigen processing. TAP transports peptides from the cytoplasm to the endoplasmic reticulum for assembly of MHC class I molecules. Loss of TAP function occurs more often in metastatic than in primary tumors. Loss of TAP1 expression may enhance tumor growth by enabling them to escape T-cell recognition during the effector phase of an antitumor immune response in immunized mice. However, it does not change the immunogenicity of tumor cells in the priming phase. Mutations in the TAP1 gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. (From LocusLink 6890, PMID 12019164 and NCI)
C21575	Neuronal_Transmission	Intercellular_Communication	Neuronal Transmission|Nerve Impulse Transmission|Nerve Transmission|Neurotransmission	Neuronal Transmission is the intercellular propagation or transfer of a signal, from a neuron to a recipient cell, consisting of an electrical current by ion flux via gap junction or diffusion a chemical neurotransmitter across a synaptic or neuromuscular junction.
C21576	Regulation_of_Cell_Size	Cell_Growth_Regulation	Regulation of Cell Size	Intracellular or extracellular processes that control, manage, or govern adoption, production, or maintenance of sustained or transient changes in cell size.  (NCI)
C21577	AFP_Gene	Ligand_Binding_Protein_Gene	AFP Gene|AFP|Alpha-Fetoprotein Gene|FETA|HPAFP	This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistence of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly.(LocusLink)
C21578	TAP2_Gene	Transport_Protein_Gene	TAP2 Gene|ABC18|ABCB3|APT2|D6S217E|PSF2|RING11|TAP2|Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) Gene	The TAP2 Gene at chromosome 6p21.3 encodes Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP), which is a member of the superfamily of ATP-binding cassette (ABC) transporters. Being a member of the MDR/TAP subfamily and a subunit of the heterodimeric TAP1/TAP2 complex (TAP), this protein is involved in antigen processing. TAP transports peptides from the cytoplasm to the endoplasmic reticulum for assembly of MHC class I molecules. Loss of TAP function occurs more often in metastatic than in primary tumors. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. (From LocusLink 6891 and NCI)
C21579	ABC_Transporter-MHC2	ABC_Transporter	Transporter 2, ATP-Binding Cassette, Sub-Family B|ABC Transporter, MHC 2|ATP-Binding Cassette, Sub-Family B, Member 3|Antigen Peptide Transporter 2|Peptide Supply Factor 2|Peptide Transporter PSF2|TAP2|Transporter 2, ABC (ATP Binding Cassette)	Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP), encoded by the TAP2 gene, is a member of the superfamily of ATP-binding cassette (ABC) transporters. Being a member of the MDR/TAP subfamily and a subunit of the heterodimeric TAP1/TAP2 complex (TAP), this protein is involved in antigen processing. TAP transports peptides from the cytoplasm to the endoplasmic reticulum for assembly of MHC class I molecules. Loss of TAP function occurs more often in metastatic than in primary tumors. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules. (From LocusLink 6891, PMID 11773612 and NCI)
C21580	TF_Gene	Ligand_Binding_Protein_Gene	TF Gene|PRO1557|Transferrin Gene	The protein encoded by this gene is a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds 1 ion of ferric iron. The function of this encoded protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. In addition to its function in iron transport, this protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter/allergins from serum. (Locuslink)
C21581	CAMLG_Gene	Ligand_Binding_Protein_Gene	CAMLG Gene|CAML|CAMLG|Calcium Modulating Ligand Gene	The CAMLG gene at chromosome 5q23 encodes Calcium Modulating Ligand (CAMLG), which blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. CAMLG binds and inactivates the key signaling intermediate calcineurin, downstream of the TCR and upstream of calcineurin, by causing an influx of calcium. This integral membrane protein may be a new participant in the calcium signal transduction pathway and implicates cyclophilin B in calcium signaling. CAMLG regulates calcium signaling in T lymphocytes and other cells. (From LocusLink and NCI)
C21582	Calcium_Signaling	Signal_Transduction	Calcium Signaling|Calcium Ion Signaling	Triggered by external stimuli, Calcium Signaling involves local influx, or mobilization from the ER through IP3R and RyR channels, of calcium ions into the cytoplasm as an intracellular second messenger in mechanisms that activate calcium-responsive signal transduction proteins that regulate diverse forms of cellular activity.
C21583	Calcium_Modulating_Ligand	Ligand_Binding_Protein	Calcium Modulating Ligand|CAMLG|Calcium-Modulating Cyclophilin Ligand|Calcium-Signal Modulating Cyclophilin Ligand|Cyclophilin B-Binding Protein	Calcium Modulating Ligand (CAMLG), encoded by the CAMLG gene, blocks a calcium-dependent signal from the T-cell receptor (TCR) that normally leads to T-cell activation. CAML binds and inactivates the key signaling intermediate calcineurin, downstream of the TCR and upstream of calcineurin, by causing an influx of calcium. This integral membrane protein may be a new participant in the calcium signal transduction pathway and implicates cyclophilin B in calcium signaling. CAML regulates calcium signaling in T lymphocytes and other cells. (From LocusLink and NCI)
C21584	Docking_Protein	Retired_Concepts	Docking Protein
C21585	CAV2_Gene	Signaling_Pathway_Gene	CAV2 Gene|CAV2|Caveolae Protein, 20-kD Gene|Caveolin 2 Gene|Caveolin-2 Gene	The CAV2 gene at chromosome 7q31.1 encodes Caveolin 2, a scaffolding protein and a major component of the inner surface of caveolae (small invaginations of the plasma membrane). CAV2 is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. CAV1 and CAV2 form Caveolin, a stable hetero-oligomeric complex important in the formation and maintenance of caveolae. CAV 2 may function as an accessory protein in conjunction with CAV 1. CAV2 interacts directly with G-protein alpha subunits and can functionally regulate their activity. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. (From LocusLink and NCI)
C21586	Caveolin-2	Signaling_Protein	Caveolin 2|CAV2|Caveolae Protein, 20-kD|Caveolin-2	Caveolin 2, encoded by the CAV2 gene, is a scaffolding protein and a major component of the inner surface of caveolae (small invaginations of the plasma membrane). CAV2 is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis. CAV1 and CAV2 form Caveolin, a stable hetero-oligomeric complex important in the formation and maintenance of caveolae. CAV2 may function as an accessory protein in conjunction with CAV1. CAV2 interacts directly with G-protein alpha subunits and can functionally regulate their activity. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. (From LocusLink and NCI)
C21587	Polyubiquitination	Ubiquitination	Polyubiquitination	The type of ubiquitin modification determines the functional consequences for the modified protein. Polyubiquitination, which involves chains of usually four or more ubiquitins, typically seen on cytoplasmic proteins, serve as an efficient signal for recognition by the proteasome and subsequent protein degradation. (From PMID and NCI)
C21588	Monoubiquitination	Ubiquitination	Monoubiquitination	The type of ubiquitin modification determines the functional consequences for the modified protein. Monoubiquitination does not serve as a proteasome targeting signal, but plays other distinct roles. Target proteins are monoubiquitinated on one or more lysine residues, which serve as a signal for intracellular sorting as well as endocytosis of cell-surface proteins. Monoubiquitination of cell-surface receptors serves as a signal to target them to lysosome, where they are degraded by lysosomal proteases. (From PMID and NCI)
C21589	CBLB_Gene	Ubiquitin_Ligase_Gene	CBLB Gene|CBLB|Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B Gene	The CALB gene at chromosome 3q13.12 encodes Cass-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B (CBLB), a member protein of the CBL family of E3 ubiquitin ligases, which are critical negative regulators of tyrosine kinase signaling pathways in the immune system. Impairment of the CBLB signaling pathway may contribute to human autoimmune diseases, including type 1 diabetes. CBLB contains putative nuclear localization signal, zinc finger, leucine zipper, and proline-rich domains. It associates with three SH3 domain proteins FYN, FGR, and PLCG1. Three isoforms (a long form, truncated isoform 1, truncated isoform 2) are produced by alternative splicing. (From OMIM, PMID and NCI)
C21590	Signal_Transduction_Protein-CBLB	E3_Ubiquitin_Ligase	Signal Transduction Protein CBLB|CBLB	Cass-Br-M (Murine) Ecotropic Retroviral Transforming Sequence B (CBLB), encoded by the CALB gene, is a member of the CBL family of E3 ubiquitin ligases, which are critical negative regulators of tyrosine kinase signaling pathways in the immune system. Impairment of the CBLB signaling pathway may contribute to human autoimmune diseases, including type 1 diabetes. CBLB contains putative nuclear localization signal, zinc finger, leucine zipper, and proline-rich domains. It associates with three SH3 domain proteins FYN, FGR, and PLCG1. Three isoforms (a long form, truncated isoform 1, truncated isoform 2) are produced by alternative splicing. (From OMIM, PMID and NCI)
C21591	G_Protein-Coupled_Receptor_Signaling	Receptor_Signaling	G Protein-Coupled Receptor Signaling|GPCR Signaling	G Protein-Coupled Receptor (GPCR) Signaling involves interactions of agonists with seven membrane-spanning receptors that induce receptor interaction with a heterotrimeric GTP-binding (G) protein complex, activation of GDP-GTP exchange on the G protein Ga subunit, dissociation of Ga from the Gbg heterodimer, and interaction of the subunits with intracellular effectors causing signal transduction cascades. GPCRs are coupled to different G protein subtypes that can activate or inhibit adenylyl cyclase, ion channels, PLC, PKC, CaM-KII, MAPKs, Src kinases, PI(3)K, Pyk2 and/or FAK in such diverse processes as neurotransmission, cellular metabolism, cell differentiation, cell proliferation, and immune responses.
C21592	CCBP2_Gene	Chemokine_Receptor_Gene	CCBP2 Gene|C-C Chemokine Receptor D6 Gene|CC-Chemokine Receptor CCR10 Gene|CC-Chemokine-Binding Receptor JAB61 Gene|CCBP2|CCR10 Gene|CCR9 Gene|CMBRK9 Gene|Chemokine (C-C Motif) Receptor 9 Gene|Chemokine (C-C) Receptor 9 Gene|Chemokine Binding Protein 2 Gene|Chemokine Receptor CCR-9 Gene|Chemokine-Binding Protein D6 Gene|D6 Gene|hD6 Gene	Expressed in placenta, lung, lymphatic endothelia, lymph nodes, intestinal mucosa/submucosa, hemopoietic cells, and fetal liver, human CCBP2 Gene (GPCR1/Beta Chemokine Receptor Family) encodes Chemokine (C-C Motif) Receptor 9, a seven transmembrane G protein-coupled receptor for beta chemokines (MCP1, MIP1-alpha, RANTES, MCP3) and critical for recruitment of effector immune cells to inflammation sites. CCBP2 does not mediate intracellular calcium flux but may function in chemokine-driven recirculation of leukocytes. (NCI)
C21593	Chemokine_Binding_Protein_2	Retired_Concepts	Chemokine Binding Protein 2|C-C Chemokine Receptor D6|CC-Chemokine Receptor CCR10|CC-Chemokine-Binding Receptor JAB61|CCBP|CCBP2|CCR10|CMBRK9|CMKBR9|Chemokine (C-C Motif) Receptor 9|Chemokine-Binding Protein D6|D6|hD6
C21594	Thiopurine_S-Methyltransferase	Methyltransferase	Thiopurine S-Methyltransferase|EC 2.1.1.67|TPMT	Thiopurine S-methyltransferase catalyzes S-methylation of thiopurine drugs such as 6-mercaptopurine. (locusLink)
C21595	TPMT_Gene	Methyltransferase_Gene	TPMT Gene|TPMT	The 34-kb 10-exon human TPMT Gene (TPMT Family) encodes monomeric 245-aa 28-kDa cytoplasmic Thiopurine S-Methyltransferase. TPMT catalyzes thiopurine S-methylation, an important metabolic pathway for thiopurine drugs such as 6-mercaptopurine and is inhibited by S-adenosyl-L-homocysteine. Individual tolerance, and therapeutic efficacy, of thiopurine drugs is associated with a polymorphism that controls levels of TPMT activity. TPMT activity varies among ethnic groups. (NCI)
C21596	CCKBR_Gene	G_Protein-Coupled_Receptor_Gene	CCKBR Gene|CCK-B receptor Gene|CCK-BR Gene|CCKBR|CCKRB Gene|Cholecystokinin B Receptor Gene|GASR Gene|Gastrin Gene	Type B (gastrin) receptors of the cholecystokinin (CCK) family are found principally in the CNS and the gastrointestinal tract. In the CNS, they regulate anxiety, arousal, neuroleptic activity, and opiate-induced analgesia. Outside the CNS, they regulate gastric acid secretion and may play a role in gastrointestinal motility and growth of normal and neoplastic gastrointestinal tissue. The CCKBR gene at chromosome 11p15.4 encodes Cholecystokinin B Receptor (CCKBR), a G protein-coupled receptor for gastrin and cholecystokinin. It activates a second messenger system involving phosphatidylinositol turnover and intracellular calcium mobilization. CCKBR can selectively be blocked by nonpeptide benzodiazepine-based antagonists. A single amino acid, valine-319, is critical in determining the binding affinity for these nonpeptide antagonists. Variability in the aliphatic side chain of the amino acid in position 319 confers antagonist specificity. (NCI)
C21597	CYP2C9_Gene	Cytochrome_P450_Family_Gene	CYP2C9 Gene|CPC9|CYP2C9|Cytochrome P450, Family 2, Subfamily C, Polypeptide 9 Gene|P450 MP-4|P450 PB-1|P450IIC9	Human CYP2C9 gene (cytochrome P450 family 2, subfamily C), located at 10q24, encodes the cytochrome P450 2C9 protein, a monooxygenase enzyme that catalyzes the metabolism of drugs and xenbiotics. Some alleles of this gene contribute to the poor metabolizer phenotype, which is characterized by the inability to use cytochrome P450-dependent metabolic pathways for drug elimination. Conversely, one allele of this gene contributes to the rapid metabolizer phenotype. Functional polymorphisms in the CYP2C9 gene have been associated with colorectal cancer.
C21598	Cholecystokinin-B_Receptor	G_Protein-Coupled_Receptor	Cholecystokinin B Receptor|CCK-B Receptor|CCK-BR|CCKBR|CCKRB|Cholecystokinin Type B Receptor|GASR	Type B (gastrin) receptors of the cholecystokinin (CCK) family are found principally in the CNS and the gastrointestinal tract. In the CNS, they regulate anxiety, arousal, neuroleptic activity, and opiate-induced analgesia. Outside the CNS, they regulate gastric acid secretion and may play a role in gastrointestinal motility and growth of normal and neoplastic gastrointestinal tissue. Cholecystokinin B Receptor (CCKBR), encoded by the CCKBR gene, is a G protein-coupled receptor for gastrin and cholecystokinin. It activates a second messenger system involving phosphatidylinositol turnover and intracellular calcium mobilization. CCKBR can selectively be blocked by nonpeptide benzodiazepine-based antagonists. A single amino acid, valine-319, is critical in determining the binding affinity for these nonpeptide antagonists. Variability in the aliphatic side chain of the amino acid in position 319 confers antagonist specificity. (NCI)
C21599	Microanatomy	Anatomic_Structure_System_or_Substance	Microanatomic Structure|Microanatomy|Microscopic Anatomy	Those anatomic structures that are generally only visible through the use of microscopy.
C21600	Mouse_Neuroglia_Neoplasm	Mouse_Neoplasms_by_Cell_Type	Mouse Neuroglia Neoplasm|Neuroglia Neoplasm
C21601	Mouse_Lobular_Neoplasm	Mouse_Neoplasms_by_Morphology	Mouse Lobular Neoplasm|Lobular Neoplasm
C21602	Mouse_Lymphoma	Mouse_Neoplasms_by_Morphology	Mouse Lymphoma|Lymphoma
C21603	Mouse_Sarcoma	Mouse_Mesenchymal_Neoplasm|Mouse_Neoplasms_by_Morphology	Mouse Sarcoma|Sarcoma
C21604	Mouse_Leukemia	Mouse_Neoplasms_by_Morphology	Mouse Leukemia|Leukemia
C21605	Mouse_Giant_Cell_Neoplasm	Mouse_Neoplasms_by_Cell_Type	Mouse Giant Cell Neoplasm|Giant Cell Neoplasm
C21606	Mouse_Mixed_Mesodermal_Tumor	Mouse_Sarcoma	Mouse Mixed Mesodermal Tumor|Mixed Mesodermal Tumor
C21607	Mouse_Malignant_Mixed_Mesodermal_Tumor	Mouse_Mixed_Mesodermal_Tumor	Mouse Malignant Mixed Mesodermal Tumor|Carcinosarcoma of the Mouse|Malignant Mixed Mesodermal Tumor
C21608	Mouse_Carcinoid_Tumor	Mouse_Carcinoma	Mouse Carcinoid Tumor|Carcinoid Tumor
C21609	Mouse_Squamous_Cell_Carcinoma	Mouse_Carcinoma|Mouse_Squamous_Cell_Neoplasm	Mouse Squamous Cell Carcinoma|Squamous Cell Carcinoma
C21610	Mouse_Undifferentiated_Carcinoma	Mouse_Carcinoma	Mouse Undifferentiated Carcinoma|Undifferentiated Carcinoma
C21611	Mouse_Small_Cell_Undifferentiated_Carcinoma	Mouse_Undifferentiated_Carcinoma	Mouse Small Cell Undifferentiated Carcinoma|Small Cell Undifferentiated Carcinoma
C21612	Mouse_Large_Cell_Undifferentiated_Carcinoma	Mouse_Undifferentiated_Carcinoma	Mouse Large Cell Undifferentiated Carcinoma|Large Cell Undifferentiated Carcinoma
C21613	Mouse_Spindle_Cell_Neoplasm	Mouse_Neoplasms_by_Cell_Type	Mouse Spindle Cell Neoplasm|Spindle Cell Neoplasm
C21614	Mouse_Intraepithelial_Neoplasia	Mouse_Neoplasms_by_Morphology	Mouse Intraepithelial Neoplasia|Intraepithelial Neoplasia
C21615	Mouse_Liposarcoma	Malignant_Mouse_Lipomatous_Neoplasm|Mouse_Sarcoma	Mouse Liposarcoma|Liposarcoma
C21616	Mouse_Benign_Mesenchymal_Neoplasm	Mouse_Mesenchymal_Neoplasm	Mouse Benign Mesenchymal Neoplasm|Benign Mesenchymal Neoplasm
C21617	Mouse_Malignant_Mesenchymal_Neoplasm	Mouse_Mesenchymal_Neoplasm	Mouse Malignant Mesenchymal Neoplasm|Malignant Mesenchymal Neoplasm
C21618	Mouse_Hemangiopericytoma	Mouse_Malignant_Mesenchymal_Neoplasm	Mouse Hemangiopericytoma|Hemangiopericytoma
C21619	Mouse_Mesothelioma	Mouse_Epithelial_Cell_Neoplasms|Mouse_Malignant_Mesenchymal_Neoplasm	Mouse Mesothelioma|Mesothelioma
C21620	Mouse_Angioma	Mouse_Benign_Mesenchymal_Neoplasm	Mouse Angioma|Angioma
C21621	Mouse_Leiomyoma	Mouse_Benign_Mesenchymal_Neoplasm	Mouse Leiomyoma|Leiomyoma
C21622	Mouse_Fibroma	Mouse_Benign_Mesenchymal_Neoplasm|Mouse_Neoplasms_by_Morphology	Mouse Fibroma|Fibroma
C21623	Mouse_Lipoma	Mouse_Benign_Mesenchymal_Neoplasm	Mouse Lipoma|Lipoma
C21624	Mouse_Myoepithelioma	Mouse_Mixed_Neoplasm	Mouse Myoepithelioma|Myoepithelioma
C21625	Mouse_Mixed_Neoplasm	Mouse_Neoplasms_by_Morphology	Mouse Mixed Neoplasm|Mixed Neoplasm
C21626	Mouse_Luminal_Carcinoma	Mouse_Adenocarcinoma	Mouse Luminal Carcinoma|Luminal Carcinoma
C21627	Mouse_Basal_Cell_Neoplasm	Mouse_Epithelial_Cell_Neoplasms	Mouse Basal Cell Neoplasm|Basal Cell Neoplasm
C21628	Mouse_Plasma_Cell_Neoplasm	Mouse_Neoplasms_by_Cell_Type	Mouse Plasma Cell Neoplasm|Plasma Cell Neoplasm
C21629	Mouse_B_Cell_Neoplasms	Mouse_Lymph_Cell_Neoplasm|Mouse_Lymphoma	Mouse B Cell Neoplasms|B Cell Neoplasms
C21630	Mouse_T_Cell_Neoplasms	Mouse_Lymph_Cell_Neoplasm|Mouse_Lymphoma	Mouse T Cell Neoplasms|T Cell Neoplasms
C21631	Mouse_Plasmacytoma	Mouse_B_Cell_Neoplasms|Mouse_Plasma_Cell_Dyscrasia	Mouse Plasmacytoma|Plasmacytoma
C21632	Mouse_Mast_Cell_Neoplasm	Mouse_Neoplasms_by_Cell_Type	Mouse Mast Cell Neoplasm|Mast Cell Neoplasm
C21633	Mouse_Granular_Cell_Neoplasm	Mouse_Neural_Cell_Neoplasm	Mouse Granular Cell Neoplasm|Granular Cell Neoplasm
C21634	Mouse_Hibernoma	Mouse_Benign_Mesenchymal_Neoplasm	Mouse Hibernoma|Hibernoma
C21635	Mouse_Stromal_Neoplasm	Mouse_Neoplasms_by_Morphology	Mouse Stromal Neoplasm|Stromal Neoplasm
C21636	Mouse_Clear_Cell_Neoplasm	Mouse_Neoplasms_by_Cell_Type	Mouse Clear Cell Neoplasm|Clear Cell Neoplasm
C21637	Mouse_Pathologic_Diagnoses	Experimental_Organism_Diagnoses	Mouse Pathologic Diagnoses|Pathologic Diagnoses
C21638	Inflammatory_Conditions_of_the_Mouse_Mammary_Gland	Mouse_Mammary_Gland_Disorder|Mouse_Noncancerous_Conditions	Inflammatory Conditions of the Mouse Mammary Gland|Inflammatory Conditions (MMB0001)|Inflammatory Conditions of the Mammary Gland
C21639	Mastitis_of_the_Mouse_Mammary_Gland	Inflammatory_Conditions_of_the_Mouse_Mammary_Gland	Mastitis of the Mouse Mammary Gland|Mastitis|Mastitis of the Mammary Gland	Inflammation of the mammary gland
C21640	Abscess_of_the_Mouse_Mammary_Gland	Inflammatory_Conditions_of_the_Mouse_Mammary_Gland	Abscess of the Mouse Mammary Gland|Abscess (MMB0003)|Abscess of the Mammary Gland	Predominant cell is a polymorphonuclear leukocyte and there is little or no fibrosis (scarring).
C21641	Granuloma_of_the_Mouse_Mammary_Gland	Inflammatory_Conditions_of_the_Mouse_Mammary_Gland	Granuloma of the Mouse Mammary Gland|Granuloma|Granuloma of the Mammary Gland	Focal granulomatous inflammation of the mammary gland. It may or may not be surrounded by a thick fibrous capsule and may or may not be associated with necrosis.
C21642	Fat_Necrosis_of_the_Mouse_Mammary_Gland	Inflammatory_Conditions_of_the_Mouse_Mammary_Gland	Fat Necrosis of the Mouse Mammary Gland|Fat Necrosis of the Mammary Gland|Fat necrosis	Lesion in the mammary gland that is a focal area of necrosis (death) of the fat cells. It is generally associated with macrophages with small lipid vacuoles in their cytoplasm and multinucleated giant cells.
C21643	Duct_Ectasia_of_the_Mouse_Mammary_Gland	Non-proliferative_Developmental_Conditions_of_the_Mouse_Mammary_Gland	Duct Ectasia of the Mouse Mammary Gland|Duct Ectasia of the Mammary Gland|Duct ectasia	Dilatation of the mammary duct without atypical cells.
C21644	Fibrosis_NOS_of_the_Mouse_Mammary_Gland	Inflammatory_Conditions_of_the_Mouse_Mammary_Gland	Fibrosis NOS of the Mouse Mammary Gland|Fibrosis (NOS) (MMB0006)|Fibrosis NOS of the Mammary Gland	An increase of connective tissue in the mammary gland.
C21645	Non-proliferative_Developmental_Conditions_of_the_Mouse_Mammary_Gland	Mouse_Mammary_Gland_Disorder|Mouse_Noncancerous_Conditions	Non-proliferative Developmental Conditions of the Mouse Mammary Gland|Developmental Conditions (Non-proliferative) (MMB0007)|Non-proliferative Developmental Conditions of the Mammary Gland
C21646	Aplasia_of_the_Mouse_Mammary_Gland	Non-proliferative_Developmental_Conditions_of_the_Mouse_Mammary_Gland	Aplasia of the Mouse Mammary Gland|Aplasia (MMB0008)|Aplasia of the Mammary Gland
C21647	Hypoplasia_of_the_Mouse_Mammary_Gland	Non-proliferative_Developmental_Conditions_of_the_Mouse_Mammary_Gland	Hypoplasia of the Mouse Mammary Gland|Hypoplasia of the Mammary Gland	A mammary gland that did extend into the fat pad but not completely or did not respond to lactogenic hormones.
C21648	Ductal_Hypoplasia_of_the_Mouse_Mammary_Gland	Hypoplasia_of_the_Mouse_Mammary_Gland	Ductal Hypoplasia of the Mouse Mammary Gland|Ductal|Ductal Hypoplasia of the Mammary Gland	A mammary gland with reduced numbers of ducts.
C21649	Lobuloacinar_Hypoplasia_of_the_Mouse_Mammary_Gland	Hypoplasia_of_the_Mouse_Mammary_Gland	Lobuloacinar Hypoplasia of the Mouse Mammary Gland|Lobuloacinar|Lobuloacinar Hypoplasia of the Mammary Gland	A mammary gland with reduced lobular development when stimulated by lactogenic hormones.
C21650	Terminal_End_Bud_Hypoplasia_of_the_Mouse_Mammary_Gland	Hypoplasia_of_the_Mouse_Mammary_Gland	Terminal End Bud Hypoplasia of the Mouse Mammary Gland|Terminal End Bud|Terminal End Bud Hypoplasia of the Mammary Gland	A mammary gland with reduced numbers of terminal end buds.
C21651	Non-Neoplastic_Proliferation_of_the_Mouse_Mammary_Gland	Mouse_Cancer-Related_Conditions|Mouse_Mammary_Gland_Disorder	Non-Neoplastic Proliferation of the Mouse Mammary Gland|Non-neoplastic Proliferation of the Mammary Gland|Non-neoplastic proliferation of the Mammary Gland
C21652	Hyperplasia_of_the_Mouse_Mammary_Gland	Non-Neoplastic_Proliferation_of_the_Mouse_Mammary_Gland	Hyperplasia of the Mouse Mammary Gland|Hyperplasia (MMB0016)|Hyperplasia of the Mammary Gland	An increase in any epithelial cells of the mammary gland.
C21653	Diffuse_Hyperplasia_of_the_Mouse_Mammary_Gland	Hyperplasia_of_the_Mouse_Mammary_Gland	Diffuse Hyperplasia of the Mouse Mammary Gland|Diffuse Hyperplasia (MMB0017)|Diffuse Hyperplasia of the Mammary Gland	Generally associated with physiological hyperplasia
C21654	Physiological_Diffuse_Hyperplasia_of_the_Mouse_Mammary_Gland	Diffuse_Hyperplasia_of_the_Mouse_Mammary_Gland	Physiological Diffuse Hyperplasia of the Mouse Mammary Gland|Physiological|Physiological Diffuse Hyperplasia of the Mammary Gland	Hyperplasia associated with increase in lactogenic hormones.
C21655	Non-physiological_Diffuse_Hyperplasia_of_the_Mouse_Mammary_Gland	Diffuse_Hyperplasia_of_the_Mouse_Mammary_Gland	Non-physiological Diffuse Hyperplasia of the Mouse Mammary Gland|Non-physiological (Developmental or induced)|Non-physiological Diffuse Hyperplasia of the Mammary Gland	Developmental or induced
C21656	Focal_Hyperplasias_of_the_Mouse_Mammary_Gland	Hyperplasia_of_the_Mouse_Mammary_Gland	Focal Hyperplasias of the Mouse Mammary Gland|Focal Hyperplasias (MMB0020)|Focal Hyperplasias of the Mammary Gland	Any increase in mammary epithelial cells that stands our from the general background.
C21657	Inflammatory_Nodule_of_the_Mouse_Mammary_Gland	Focal_Hyperplasias_of_the_Mouse_Mammary_Gland	Inflammatory Nodule of the Mouse Mammary Gland|Inflammatory Nodule|Inflammatory Nodule of the Mammary Gland	A focal area of chronic inflammation with fibrosis. It generally surrounds a lobule. The acini within the lobules generally have epithelial cells with large, hyperchromatic and somewhat pleomorphic nuclei.
C21658	Squamous_Nodule_of_the_Mouse_Mammary_Gland	Focal_Hyperplasias_of_the_Mouse_Mammary_Gland	Squamous Nodule of the Mouse Mammary Gland|Squamous Nodule|Squamous Nodule of the Mammary Gland	A focal area of hyperplasia in which the majority of the glandular epithelium has been replaced by squamous epithelium. The squamous nodule frequently has an inflammatory stroma but with less inflammation than observed in an inflammatory nodule.
C21659	Other_Focal_Hyperplasias_of_the_Mouse_Mammary_Gland	Focal_Hyperplasias_of_the_Mouse_Mammary_Gland	Other Focal Hyperplasias of the Mouse Mammary Gland|Other Focal Hyperplasias|Other Focal Hyperplasias of the Mammary Gland	A focal hyperplasia that is not inflammatory or squamous.
C21660	Other_Non-neoplastic_Proliferations_of_the_Mouse_Mammary_Gland	Non-Neoplastic_Proliferation_of_the_Mouse_Mammary_Gland	Other Non-neoplastic Proliferations of the Mouse Mammary Gland|Other Non-neoplastic Proliferations of the Mammary Gland|Other Non-neoplastic proliferations
C21661	Neoplasms_of_the_Mouse_Mammary_Gland	Mouse_Integumentary_System_Neoplasms|Mouse_Mammary_Gland_Disorder	Neoplasms of the Mouse Mammary Gland|Neoplasms of the Mammary Gland	Neoplasms (benign or malignant) of the mammary epithelium. Does not include other neoplasms that originate from the parenchyma of the mammary fat pad (i.e., sarcomas, lymphomas, angiomas, etc.).
C21662	Benign_Neoplasms_of_the_Mouse_Mammary_Gland	Neoplasms_of_the_Mouse_Mammary_Gland	Benign Neoplasms of the Mouse Mammary Gland|Benign Neoplasms (MMB0025)|Benign Neoplasms of the Mammary Gland	Autonomous new growth of well-differentiated mammary epithelium that has limited growth potential does not metastasize or invade surrounding structures and has normal cytology.
C21663	Fibroadenoma_of_the_Mouse_Mammary_Gland	Benign_Neoplasms_of_the_Mouse_Mammary_Gland|Mouse_Adenoma	Fibroadenoma of the Mouse Mammary Gland|Fibroadenoma of the Mammary Gland	A focal benign neoplastic lesion of the mammary gland that is composed of ducts in an expanded myxoid connective tissue matrix.
C21664	Papilloma_of_the_Mouse_Mammary_Gland	Benign_Neoplasms_of_the_Mouse_Mammary_Gland|Mouse_Papilloma	Papilloma of the Mouse Mammary Gland|Papilloma (MMB0027)|Papilloma of the Mammary Gland	A benign neoplasm composed of finger-like projections of fibrovascular connective tissue covered by epithelium.
C21665	Adenoma_of_the_Mouse_Mammary_Gland	Benign_Neoplasms_of_the_Mouse_Mammary_Gland|Mouse_Adenoma	Adenoma of the Mouse Mammary Gland|Adenoma (MMB0028)|Adenoma of the Mammary Gland	A benign neoplastic proliferation of glandular units (acini) with a non-invasive, expansile margin.
C21666	Adenomyoepithelioma_of_the_Mouse_Mammary_Gland	Benign_Neoplasms_of_the_Mouse_Mammary_Gland|Mouse_Myoepithelioma	Adenomyoepithelioma of the Mouse Mammary Gland|Adenomyoepithelioma|Adenomyoepithelioma of the Mammary Gland	A benign tumor composed of both myoepithelium and glands.
C21667	Intraepithelial_Neoplasia_of_the_Mouse_Mammary_Gland	Mouse_Intraepithelial_Neoplasia|Neoplasms_of_the_Mouse_Mammary_Gland	Intraepithelial Neoplasia of the Mouse Mammary Gland|Intraepithelial Neoplasia of the Mammary Gland|MIN|Mammary Intraepithelial Neoplasia|Proliferative Diseases of the Mouse Mammary Gland With Cytological Atypia and Defined or Unknown Malignant Potential	A focal, non-invasive epithelial lesion composed of cells with atypical cytology and/or organization and risk of progressing to malignancy. Biological proof that the lesions are at high risk of malignant transformation depends on identification, isolation and transplantation of the focus into the mammary fat pad. The term Mammary Intraepithelial Neoplasia (MIN) has been recommended by the Annapolis Pathology Panel for all terms under C500148 (focal, atypical mouse mammary lesions). These lesions are identified because they are focal, cytological atypical and associated with mammary cancer in adjacent tissue or glands.
C21668	Low_Grade_Mouse_MIN	Intraepithelial_Neoplasia_of_the_Mouse_Mammary_Gland	Low Grade Mouse MIN|DIN|Focal Hyperplasia of the Mouse Mammary Gland with High Grade Atypia|Low Grade AH|Low Grade Focal Atypical Hyperplasia of the Mouse Mammary Gland|Low Grade MIN	A focal atypical, non-invasive epithelial lesion with minimal atypia and low malignant potential. Atypical hyperplasia, DIN and certain grades of DCIS are considered human homologs. Focal increase of epithelium that contains cells with atypical nuclei. Limited to focal lesions with mild to moderate cytological atypia. When transplanted, the foci grow in gland cleared mammary fat pads but not in the subcutaneous tissue. Low grade lesions seldom undergo malignant transformation and do not metastasize. Mammary Intraepithelial Neoplasia (MIN) has been proposed by the Annapolis Pathology Panel as the preferred term. It is considered the mouse counterpart or synonym for Atypical Hyperplasia, DIN in the human breast. Some pathologists believe that these proliferations are premalignant. Nuclear atypia corresponds to a nuclear score of one in the Elston-Ellis grading system.
C21669	LobuloAlveolar_Mouse_MIN	Low_Grade_Mouse_MIN	LobuloAlveolar Mouse MIN|HAN|LobuloAlveolar Hyperplasia of the Mouse Mammary Gland with Low Grade Atypia|LobuloAlveolar Low Grade Focal Atypical Hyperplasia of the Mouse Mammary Gland|LobuloAlveolar MIN	A focus of residual alveoli that persist in the mouse mammary gland following hormone stimulation
C21670	Ductal_Mouse_MIN	Low_Grade_Mouse_MIN	Ductal Mouse MIN|ADD|Ductal Focal Hyperplasia of the Mouse Mammary Gland with Low Grade Atypia|Ductal Low Grade Focal Atypical Hyperplasia of the Mouse Mammary Gland|Ductal MIN|Hormone Dependent Tumor|Plaque	Focal dysmorphogenesis of ducts leading to a proliferation of atypical cells in the terminal ducts and/or the collecting ducts
C21671	Mouse_MIN_NOS	Intraepithelial_Neoplasia_of_the_Mouse_Mammary_Gland	Mouse MIN NOS|Atypical Hyperplasia NOS of the Mouse Mammary Gland|Focal Hyperplasia with Atypia NOS of the Mouse Mammary Gland|MIN NOS	MIN NOS (Not Otherwise Specified) is a mammary intraepithelial neoplasm without established or known biological potential
C21672	Simple_Mouse_MIN_NOS	Mouse_MIN_NOS	Simple Mouse MIN NOS|Simple Atypical Hyperplasia NOS of the Mouse Mammary Gland|Simple Focal Hyperplasia NOS of the Mouse Mammary Gland|Simple MIN NOS	MIN NOS (Not Otherwise Specified) without a specific growth pattern. Generally reserved for low grade MIN without complex growth patterns.
C21673	Cystic_Mouse_MIN_NOS	Mouse_MIN_NOS	Cystic Mouse MIN NOS|Cystic Atypical Hyperplasia NOS of the Mouse Mammary Gland|Cystic Focal Hyperplasia NOS of the Mouse Mammary Gland|Cystic MIN NOS	MIN NOS that forms cystic structures filled with fluid.
C21674	Solid_Mouse_MIN_NOS	Mouse_MIN_NOS	Solid Mouse MIN NOS|Solid Atypical Hyperplasia NOS of the Mouse Mammary Gland|Solid Focal Hyperplasia NOS of the Mouse Mammary Gland|Solid MIN NOS	MIN NOS that does not form luminal structures.
C21675	Mixed_Mouse_MIN_NOS	Mouse_MIN_NOS	Mixed Mouse MIN NOS|Mixed Atypical Hyperplasia NOS of the Mouse Mammary Gland|Mixed Focal Hyperplasia NOS of the Mouse Mammary Gland|Mixed MIN NOS	MIN NOS that has a mixture of features.
C21676	High_Grade_Mouse_MIN	Intraepithelial_Neoplasia_of_the_Mouse_Mammary_Gland	High Grade Mouse MIN|Focal Hyperplasia of the Mouse Mammary Gland with High Grade Atypia|High Grade Focal Atypical Hyperplasia of the Mouse Mammary Gland|High Grade MIN	A focal atypical, non-invasive epithelial lesion with severe atypia and high malignant potential. Focal increase of epithelium that contains cells with highly atypical nuclei. Nuclear atypia corresponds to a nuclear score of 2 or three in the Elston-Ellis grading system.  These lesions have more severe atypia, higher mitotic rate. Biological criteria is based on transplantation. High risk lesions grow in the gland cleared mammary fat pad and frequently result in tumors and metastasis.
C21677	Carcinoma_in_Situ_of_the_Mouse_Mammary_Gland	Intraepithelial_Neoplasia_of_the_Mouse_Mammary_Gland	Carcinoma in Situ of the Mouse Mammary Gland|Carcinoma in Situ of the Mammary Gland|Carcinoma in situ (aka MIN)|MIN	The term MIN or Carcinoma in situ should be limited to small foci of atypical cells that are confined within the basement membrane but will grow as invasive tumors when transplanted into the subcutaneous tissue
C21678	Malignant_Neoplasms_of_the_Mouse_Mammary_Gland	Neoplasms_of_the_Mouse_Mammary_Gland	Malignant Neoplasms of the Mouse Mammary Gland|Malignant Neoplasms (MMB0046)|Malignant Neoplasms of the Mammary Gland	A neoplastic growth that invades the normal tissue and/or metastasizes to distant organs.
C21679	Carcinoma_of_the_Mouse_Mammary_Gland_Histologic_Patterns	Malignant_Neoplasms_of_the_Mouse_Mammary_Gland	Carcinoma of the Mouse Mammary Gland: Histologic Patterns|Carcinoma of the Mammary Gland: Histologic Patterns|Carcinoma: Histologic patterns	A malignant neoplasm that originates from epithelium.
C21680	Luminal_Carcinoma_of_the_Mouse_Mammary_Gland	Carcinoma_of_the_Mouse_Mammary_Gland_Histologic_Patterns|Mouse_Luminal_Carcinoma	Luminal Carcinoma of the Mouse Mammary Gland|Luminal|Luminal Carcinoma of the Mammary Gland	A mammary epithelial cell that is not myoepithelial. The luminal cells may include ductal, alveolar, and stem cell populations.
C21681	Acinar_Mammary_Carcinoma_of_Mouse	Luminal_Carcinoma_of_the_Mouse_Mammary_Gland	Acinar Mammary Carcinoma of Mouse|Acinar Mammary Carcinoma	Forms small glandular structures without prominent gland lumen.
C21682	Glandular_Mammary_Carcinoma_of_Mouse	Luminal_Carcinoma_of_the_Mouse_Mammary_Gland	Glandular Mammary Carcinoma of Mouse|Glandular Mammary Carcinoma	Forms glandular structures with abundant secretory products in lumen.
C21683	Cribriform_Mammary_Carcinoma_of_Mouse	Luminal_Carcinoma_of_the_Mouse_Mammary_Gland	Cribriform Mammary Carcinoma of Mouse|Cribriform Mammary Carcinoma	Forms sheets of cells with back-to-back gland-like lumens.
C21684	Papillary_Mammary_Carcinoma_of_Mouse	Luminal_Carcinoma_of_the_Mouse_Mammary_Gland	Papillary Mammary Carcinoma of Mouse|Papillary Mammary Carcinoma	Forms finger-like fibrovascular projections covered with neoplastic epithelium.
C21685	Solid_Mammary_Carcinoma_of_Mouse	Luminal_Carcinoma_of_the_Mouse_Mammary_Gland	Solid Mammary Carcinoma of Mouse|Solid Mammary Carcinoma	Forms solid masses of tumor cells, frequently in a nodular configuration.
C21686	Other_Mammary_Carcinoma_of_Mouse	Luminal_Carcinoma_of_the_Mouse_Mammary_Gland	Other Mammary Carcinoma of Mouse|Other Mammary Carcinoma	A malignant neoplasm without specific characteristics or NOS.
C21687	Myoepithelial_Carcinoma_of_the_Mouse_Mammary_Gland	Carcinoma_of_the_Mouse_Mammary_Gland_Histologic_Patterns|Mouse_Myoepithelioma	Myoepithelial Carcinoma of the Mouse Mammary Gland|Myoepithelial|Myoepithelial Carcinoma of the Mammary Gland	A malignant neoplasm primarily composed of a spindle cell stroma. May or may not have an identifiable glandular component.
C21688	Myoepithelial_and_Mixed_Glandular_Myoepithelial_Carcinoma_of_the_Mouse_Mammary_Gland	Myoepithelial_Carcinoma_of_the_Mouse_Mammary_Gland	Myoepithelial and Mixed Glandular Myoepithelial Carcinoma of the Mouse Mammary Gland|Myoepithelial and Mixed Glandular Myoepithelial Carcinoma of the Mammary Gland|Myoepithelial carcinoma (Mixed glandular and myoepithelial)	A malignant neoplasm that has myoepithelial differentiation (generally detected by the mixture of glands and spindle cells and/or the presence of smooth muscle actin in the cytoplasm of the spindle cells).
C21689	Monomorphic_Myoepithelial_Spindle_Cell_Carcinoma_of_the_Mouse_Mammary_Gland	Mouse_Spindle_Cell_Neoplasm|Myoepithelial_Carcinoma_of_the_Mouse_Mammary_Gland	Monomorphic Myoepithelial Spindle Cell Carcinoma of the Mouse Mammary Gland|Monomorphic Myoepithelial Spindle Cell Carcinoma of the Mammary Gland|Spindle Cell (monomorphic myoepithelial)	A malignant neoplasm that is composed of spindle cells that contain one or more keratins.
C21690	Metaplastic_Carcinoma_of_the_Mouse_Mammary_Gland	Carcinoma_of_the_Mouse_Mammary_Gland_Histologic_Patterns	Metaplastic Carcinoma of the Mouse Mammary Gland|Metaplastic (mixed or monomorphic)|Metaplastic Carcinoma of the Mammary Gland	Mixed or monomorphic
C21691	Adenosquamous_Metaplastic_Carcinoma_of_the_Mouse_Mammary_Gland	Metaplastic_Carcinoma_of_the_Mouse_Mammary_Gland|Mouse_Adenosquamous_Carcinoma	Adenosquamous Metaplastic Carcinoma of the Mouse Mammary Gland|Adenosquamous Metaplastic Carcinoma of the Mammary Gland|Keratoacanthoma|Metaplastic Carcinoma, Adenosquamous (aka Keratoacanthoma)	A malignant neoplasm that has both glandular and squamous differentiation.
C21692	Squamous_Metaplastic_Carcinoma_of_the_Mouse_Mammary_Gland	Metaplastic_Carcinoma_of_the_Mouse_Mammary_Gland|Mouse_Squamous_Cell_Carcinoma	Squamous Metaplastic Carcinoma of the Mouse Mammary Gland|Metaplastic Carcinoma, Squamous|Squamous Metaplastic Carcinoma of the Mammary Gland	A malignant neoplasm that has squamous differentiation.
C21693	Osseous_Metaplastic_Carcinoma_of_the_Mouse_Mammary_Gland	Metaplastic_Carcinoma_of_the_Mouse_Mammary_Gland	Osseous Metaplastic Carcinoma of the Mouse Mammary Gland|Metaplastic Carcinoma, Osseous|Osseous Metaplastic Carcinoma of the Mammary Gland	A malignant neoplasm with osseous differentiation.
C21694	Spindle_Cell_Metaplastic_Carcinoma_of_the_Mouse_Mammary_Gland	Metaplastic_Carcinoma_of_the_Mouse_Mammary_Gland|Mouse_Spindle_Cell_Neoplasm	Spindle Cell Metaplastic Carcinoma of the Mouse Mammary Gland|Metaplastic Carcinoma, Spindle Cell|Spindle Cell Metaplastic Carcinoma of the Mammary Gland	A malignant neoplasm of the epithelium with spindle cell differentiation. See EMT Tumor.
C21695	Other_Metaplastic_Carcinomas_of_the_Mouse_Mammary_Gland	Metaplastic_Carcinoma_of_the_Mouse_Mammary_Gland	Other Metaplastic Carcinomas of the Mouse Mammary Gland|Other Metaplastic Carcinomas|Other Metaplastic Carcinomas of the Mammary Gland	A malignant neoplasm with other metaplastic characteristics not specified by siblings.
C21696	Other_Cancer_of_the_Mouse_Mammary_Gland_NOS	Malignant_Neoplasms_of_the_Mouse_Mammary_Gland	Other Cancer of the Mouse Mammary Gland NOS|Other Cancer (NOS)|Other Cancer of the Mammary Gland NOS	A malignant neoplasm of the mammary epithelium that cannot be otherwise classified.
C21697	Inflammatory_Conditions_of_the_Mouse_Prostate_Gland	Mouse_Noncancerous_Conditions|Mouse_Prostate_Disorder	Inflammatory Conditions of the Mouse Prostate Gland|Inflammatory Conditions (MMY0001)|Inflammatory Conditions of the Prostate Gland
C21698	Mouse_Prostatitis	Inflammatory_Conditions_of_the_Mouse_Prostate_Gland	Mouse Prostatitis|Prostatitis	Inflammatory process characterized by infiltration of inflammatory cells into prostatic stromal and glandular elements.
C21699	Chronic_Active_Prostatitis_of_Mouse	Mouse_Prostatitis	Chronic Active Prostatitis of Mouse|Active (Chronic active)|Chronic Active Prostatitis	Inflammatory process characterized by infiltration of inflammatory cells into prostatic stromal and glandular elements.
C21700	Infectious_Granulomatous_Prostatitis_of_Mouse	Mouse_Prostatitis	Infectious Granulomatous Prostatitis of Mouse|Granulomatous, infectious|Infectious Granulomatous Prostatitis	Type of chronic prostatic inflammation, characterized microscopically by a dominant component of granuluomas or cell types characteristic of granulomas, that is histiocytes/macrophages.
C21701	Abscess_of_the_Mouse_Prostate_Gland	Inflammatory_Conditions_of_the_Mouse_Prostate_Gland	Abscess of the Mouse Prostate Gland|Abscess (MMY0005)|Abscess of the Prostate Gland	An abscess is characterized histologically by sheet-like infiltration of neutrophils, with a cavity formed in areas of frank tissue destruction.
C21702	Coagulative_Necrosis_of_the_Mouse_Prostate_Gland	Inflammatory_Conditions_of_the_Mouse_Prostate_Gland	Coagulative Necrosis of the Mouse Prostate Gland|Coagulative Necrosis of the Prostate Gland|Necrosis, coagulative	Coagulative necrosis is a form of tissue necrosis in which the basic outline of the cells and tissues is maintained.
C21703	Fibrosis_NOS_of_the_Mouse_Prostate_Gland	Inflammatory_Conditions_of_the_Mouse_Prostate_Gland	Fibrosis NOS of the Mouse Prostate Gland|Fibrosis (NOS) (MMY0007)|Fibrosis NOS of the Prostate Gland	Fibrosis refers to the deposition of extracellular collagen and such "scarring" is a potential consequence of inflammation.
C21704	Non-proliferative_Developmental_Conditions_of_the_Mouse_Prostate_Gland	Mouse_Noncancerous_Conditions|Mouse_Prostate_Disorder	Non-proliferative Developmental Conditions of the Mouse Prostate Gland|Developmental Conditions (Non-proliferative) (MMY0008)|Non-proliferative Developmental Conditions of the Prostate Gland	Could conceivably occur as part of a spectrum of GU developmental abnormality (e.g., 5-alpha-reductase deficiency in humans).
C21705	Aplasia_of_the_Mouse_Prostate_Gland	Non-proliferative_Developmental_Conditions_of_the_Mouse_Prostate_Gland	Aplasia of the Mouse Prostate Gland|Aplasia of the Prostate Gland	Agenesis/Aplasia describes the absence of an organ due to the lack of formation and development of its primordium in the embryo.
C21706	Hypoplasia_of_the_Mouse_Prostate_Gland	Non-proliferative_Developmental_Conditions_of_the_Mouse_Prostate_Gland	Hypoplasia of the Mouse Prostate Gland|Hypoplasia of the Prostate Gland	Hypoplasia refers to inadequate development or underdevelopment of an organ. The prostate should be small for age and may or may not have associated histologic abnormalities.
C21707	Non-neoplastic_Proliferation_of_the_Murine_Prostate_Gland	Mouse_Cancer-Related_Conditions|Mouse_Prostate_Disorder	Non-neoplastic Proliferation of the Mouse Prostate Gland|Non-neoplastic Proliferation of the Prostate Gland|Non-neoplastic proliferation of the Prostate Gland
C21708	Hyperplasia_of_the_Mouse_Prostate_Gland	Non-neoplastic_Proliferation_of_the_Murine_Prostate_Gland	Hyperplasia of the Mouse Prostate Gland|Hyperplasia of the Prostate Gland	Hyperplasia as an increase in glandular/stromal tissue compared to age matched wild type control mice.
C21709	Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland	Hyperplasia_of_the_Mouse_Prostate_Gland	Diffuse Hyperplasia of the Mouse Prostate Gland|Diffuse Hyperplasia (MMY0015)|Diffuse Hyperplasia of the Prostate Gland
C21710	Physiological_Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland	Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland	Physiological Diffuse Hyperplasia of the Mouse Prostate Gland|Physiological Diffuse Hyperplasia|Physiological Diffuse Hyperplasia of the Prostate Gland
C21711	Non-physiological_Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland	Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland	Non-physiological Diffuse Hyperplasia of the Mouse Prostate Gland|Non-physiological (Developmental or induced) Diffuse Hyperplasia|Non-physiological Diffuse Hyperplasia of the Prostate Gland	Developmental or induced
C21712	Epithelial_Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland	Non-physiological_Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland	Epithelial Diffuse Hyperplasia of the Mouse Prostate Gland|Epithelial Diffuse Hyperplasia|Epithelial Diffuse Hyperplasia of the Prostate Gland	Diffuse hyperplasia refers to a more extensive or uniform epithelial hyperplasia, generally involving >50% of the gland spaces.
C21713	Stromal_Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland	Non-physiological_Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland	Stromal Diffuse Hyperplasia of the Mouse Prostate Gland|Stromal Diffuse Hyperplasia|Stromal Diffuse Hyperplasia of the Prostate Gland	Stromal Hyperplasia is a non-neoplastic increase in the cellularity of the stromal component of the prostate compared to age matched controls.
C21714	Combined_Epithelial_Stromal_Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland	Non-physiological_Diffuse_Hyperplasia_of_the_Mouse_Prostate_Gland	Combined Epithelial / Stromal Diffuse Hyperplasia of the Mouse Prostate Gland|Combined Epithelial / Stromal Diffuse Hyperplasia of the Prostate Gland|Combined epithelial/stromal Diffuse Hyperplasia
C21715	Focal_Hyperplasias_of_the_Mouse_Prostate_Gland	Hyperplasia_of_the_Mouse_Prostate_Gland	Focal Hyperplasias of the Mouse Prostate Gland|Focal Hyperplasias of the Prostate Gland	without nuclear atypia, which is classified with high risk disorders; can be multifocal; if greater than 50 % involvement, classify as diffuse.
C21716	Physiological_Focal_Hyperplasia_of_the_Mouse_Prostate_Gland	Focal_Hyperplasias_of_the_Mouse_Prostate_Gland	Physiological Focal Hyperplasia of the Mouse Prostate Gland|Physiological Focal Hyperplasia|Physiological Focal Hyperplasia of the Prostate Gland
C21717	Non-physiological_Focal_Hyperplasia_of_the_Mouse_Prostate_Gland	Focal_Hyperplasias_of_the_Mouse_Prostate_Gland	Non-physiological Focal Hyperplasia of the Mouse Prostate Gland|Non-physiological (Developmental or induced) Focal Hyperplasia|Non-physiological Focal Hyperplasia of the Prostate Gland	Developed or induced
C21718	Epithelial_Focal_Hyperplasia_of_the_Mouse_Prostate_Gland	Non-physiological_Focal_Hyperplasia_of_the_Mouse_Prostate_Gland	Epithelial Focal Hyperplasia of the Mouse Prostate Gland|Epithelial Focal Hyperplasia|Epithelial Focal Hyperplasia of the Prostate Gland	Focal refers to epithelial hyperplasia involving one or a few gland spaces.
C21719	Stromal_Focal_Hyperplasia_of_the_Mouse_Prostate_Gland	Non-physiological_Focal_Hyperplasia_of_the_Mouse_Prostate_Gland	Stromal Focal Hyperplasia of the Mouse Prostate Gland|Stromal Focal Hyperplasia|Stromal Focal Hyperplasia of the Prostate Gland	Focal refers to stromal hyperplasia involving a minor component of the stromal compartment.
C21720	Combined_Epithelial_Stromal_Focal_Hyperplasia_of_the_Mouse_Prostate_Gland	Non-physiological_Focal_Hyperplasia_of_the_Mouse_Prostate_Gland	Combined Epithelial / Stromal Focal Hyperplasia of the Mouse Prostate Gland|Combined Epithelial / Stromal Focal Hyperplasia of the Prostate Gland|Combined epithelial/stromal Focal Hyperplasia
C21721	Other_Non-Neoplastic_Proliferation_of_the_Mouse_Prostate_Gland	Non-neoplastic_Proliferation_of_the_Murine_Prostate_Gland	Other Non-Neoplastic Proliferation of the Mouse Prostate Gland|Other Non-neoplastic Proliferation of the Prostate Gland|Other Non-neoplastic proliferation of the Prostate Gland
C21722	Neoplasms_of_the_Mouse_Prostate_Gland	Mouse_Male_Reproductive_System_Neoplasms|Mouse_Prostate_Disorder	Neoplasms of the Mouse Prostate Gland|Neoplasms of the Prostate Gland
C21723	High_Risk_Proliferative_Disease_of_the_Mouse_Prostate_Gland_of_Unknown_or_Premalignant_Potential	Mouse_Precancerous_Conditions|Neoplasms_of_the_Mouse_Prostate_Gland	High Risk Proliferative Disease of the Mouse Prostate Gland of Unknown or Premalignant Potential|High Risk Proliferative Disease of the Prostate Gland of Unknown or Premalignant Potential|High risk proliferative disease of unknown or premalignant potential
C21724	Atypical_Hyperplasia_of_the_Mouse_Prostate_Gland	High_Risk_Proliferative_Disease_of_the_Mouse_Prostate_Gland_of_Unknown_or_Premalignant_Potential	Atypical Hyperplasia of the Mouse Prostate Gland|Atypical Hyperplasia of the Prostate Gland|Focal atypical hyperplasia, mild	Terms low grade and high grade PIN should be reserved for models in which the epithelial lesion has documented potential to progress to invasive carcinoma.
C21725	Epithelial_Atypical_Hyperplasia_of_the_Mouse_Prostate_Gland	Atypical_Hyperplasia_of_the_Mouse_Prostate_Gland	Epithelial Atypical Hyperplasia of the Mouse Prostate Gland|Epithelial Atypical Hyperplasia of the Prostate Gland|Epithelial Focal atypical Hyperplasia, mild	Terms describing the degree of nuclear atypia, such as mild or severe, can be applied (analogous to distinctions between low and high grade PIN described below).  However, the criteria, reproducibility, and biologic significance of such distinctions remain to be determined.
C21726	Stromal_Atypical_Hyperplasia_of_the_Mouse_Prostate_Gland	Atypical_Hyperplasia_of_the_Mouse_Prostate_Gland	Stromal Atypical Hyperplasia of the Mouse Prostate Gland|Stromal Atypical Hyperplasia of the Prostate Gland|Stromal Focal atypical hyperplasia, mild
C21727	Combined_Epithelial_Stromal_Atypical_Hyperplasia_of_the_Mouse_Prostate_Gland	Atypical_Hyperplasia_of_the_Mouse_Prostate_Gland	Combined Epithelial / Stromal Atypical Hyperplasia of the Mouse Prostate Gland|Combined Epithelial / Stromal Atypical Hyperplasia of the Prostate Gland|Combined epithelia / stromal focal atypical hyperplasia, mild|Papilloma; Phylloides-like tumor	Herniating or protruding into periprostatic fat needs to be distinguished from true invasion.
C21728	Prostatic_Intraepithelial_Neoplasia_of_the_Mouse_Prostate_Gland	High_Risk_Proliferative_Disease_of_the_Mouse_Prostate_Gland_of_Unknown_or_Premalignant_Potential|Mouse_Intraepithelial_Neoplasia	Prostatic Intraepithelial Neoplasia of the Mouse Prostate Gland|PIN|Prostatic Intraepithelial Neoplasia of the Prostate Gland|Prostatic intraepithelial neoplasia (PIN)	Conceptually, distinguished from epithelial hyperplasia with atypia by unequivocally documented association with invasive carcinoma, such that the terms PIN/HGPIN have similar meaning/implications as in human.  Thus far, such invasion has been observed primarily in SV40 early region/large T antigen containing transgenes (and possibly the BK5-IGF1 mouse).  In these models, the in situ lesions CAN be distinguished morphologically from mice showing epithelial proliferation with atypia.  T antigen models show much more pronounced nuclear atypia, including greater nuclear enlargement and pleomorphism, coarser chromatin, irregular nuclear contours, and higher mitotic and apoptotic rates.
C21729	Low_Grade_Mouse_Prostatic_Intraepithelial_Neoplasia	Prostatic_Intraepithelial_Neoplasia_of_the_Mouse_Prostate_Gland	Low Grade Mouse Prostatic Intraepithelial Neoplasia|Low Grade Prostatic Intraepithelial Neoplasia|Low grade prostatic intraepithelial neoplasia	mPIN which has not shown documented progression to invasive cancer.
C21730	High_Grade_Mouse_Prostatic_Intraepithelial_Neoplasia	Prostatic_Intraepithelial_Neoplasia_of_the_Mouse_Prostate_Gland	High Grade Mouse Prostatic Intraepithelial Neoplasia|High Grade Prostatic Intraepithelial Neoplasia|High grade prostatic intraepithelial neoplasia	High grade based on marked nuclear atypia, including macronucleoli, marked enlargement with hyperchromasia and irregular nuclear contours, abundant mitoses/apoptosis, luminal comedo necrosis.
C21731	Malignant_Neoplasms_of_the_Mouse_Prostate_Gland	Neoplasms_of_the_Mouse_Prostate_Gland	Malignant Neoplasms of the Mouse Prostate Gland|Malignant Neoplasms (MMY0041)|Malignant Neoplasms of the Prostate Gland
C21732	Carcinoma_of_the_Mouse_Prostate_Gland	Malignant_Neoplasms_of_the_Mouse_Prostate_Gland|Mouse_Carcinoma	Carcinoma of the Mouse Prostate Gland|Carcinoma|Carcinoma of the Prostate Gland	Invasive carcinoma is the penetration of malignant cells through the basement membrane into the surrounding stromal.
C21733	Microinvasive_Carcinoma_of_the_Mouse_Prostate_Gland	Carcinoma_of_the_Mouse_Prostate_Gland	Microinvasive Carcinoma of the Mouse Prostate Gland|MI|Microinvasive Carcinoma (MI)|Microinvasive Carcinoma of the Prostate Gland	Conceptually the earliest forms of invasive carcinoma, with extension of malignant cells through basement membrane of HGPIN glands into surrounding thin rim of stroma.  Can be difficult to distinguish from tangential sections of HGPIN glands, especially given the extensive nature of HGPIN in most models showing progression and the thin rim of stroma in mouse.  Adjunctive methodologies may be warranted, especially in models not showing progression to more definitive and unequivocal invasive carcinoma.
C21734	Microinvasive_Adenocarcinoma_of_the_Mouse_Prostate_Gland	Microinvasive_Carcinoma_of_the_Mouse_Prostate_Gland|Mouse_Adenocarcinoma	Microinvasive Adenocarcinoma of the Mouse Prostate Gland|Microinvasive Adenocarcinoma (Glandular/acinar)|Microinvasive Adenocarcinoma of the Prostate Gland	Microinvasive carcinoma is the earliest recognizable form of invasive carcinoma, with penetration of malignant cells through the basement membrane into the surrounding stroma.
C21735	Undifferentiated_Microinvasive_Carcinoma_of_the_Mouse_Prostate_Gland	Microinvasive_Carcinoma_of_the_Mouse_Prostate_Gland|Mouse_Undifferentiated_Carcinoma	Undifferentiated Microinvasive Carcinoma of the Mouse Prostate Gland|Microinvasive carcinoma NOS|Undifferentiated Microinvasive Carcinoma|Undifferentiated Microinvasive Carcinoma of the Prostate Gland	No cytologic features of glandular or NE differentiation; no secretory or NE differentiation on special stains or immunohistochemistry if performed.
C21736	Microinvasive_Neuroendocrine_Carcinoma_of_the_Mouse_Prostate_Gland	Microinvasive_Carcinoma_of_the_Mouse_Prostate_Gland	Microinvasive Neuroendocrine Carcinoma of the Mouse Prostate Gland|Microinvasive NE Carcinoma of the Mouse Prostate Gland|Microinvasive Neuroendocrine (NE) carcinoma|Microinvasive Neuroendocrine Carcinoma of the Prostate Gland	Morphology includes solid and rosetting, with scant to moderate cytoplasm, nuclear features of NE carcinoma or with immunophenotypic documentation
C21737	Microinvasive_Small_Cell_Carcinoma_of_the_Mouse_Prostate_Gland	Microinvasive_Neuroendocrine_Carcinoma_of_the_Mouse_Prostate_Gland|Mouse_Small_Cell_Undifferentiated_Carcinoma	Microinvasive Small Cell Carcinoma of the Mouse Prostate Gland|Microinvasive Small Cell Carcinoma of the Prostate Gland|Microinvasive Small cell carcinoma	Morphologically identical/similar to small cell carcinoma of human lung, prostate; less cytoplasm with more pronounced nuclear hyperchromasia and molding than in NE carcinoma.
C21738	Invasive_Carcinoma_of_the_Mouse_Prostate_Gland	Carcinoma_of_the_Mouse_Prostate_Gland	Invasive Carcinoma of the Mouse Prostate Gland|IC of the Mouse Prostate Gland|Invasive Carcinoma (IC)|Invasive Carcinoma of the Prostate Gland	Obvious extension of glands, nests or single cells extensively into stroma, including with apparent widening of the stroma (eosinophilic collagenous tissue), potentially reflecting desmoplasia, or into periprostatic fat
C21739	Invasive_Adenocarcinoma_of_the_Mouse_Prostate_Gland	Invasive_Carcinoma_of_the_Mouse_Prostate_Gland|Mouse_Adenocarcinoma	Invasive Adenocarcinoma of the Mouse Prostate Gland|Invasive Adenocarcinoma (Glandular/acinar)|Invasive Adenocarcinoma of the Prostate Gland	Invasive carcinoma is the penetration of malignant epithelial cells (that demonstrates unequivocal glandular proliferation) through the basement membrane into the surrounding stroma (Degree of differentiation will be defined based on the extent of glandular proliferation).
C21740	Moderately_Differentiated_Invasive_Adenocarcinoma_of_the_Mouse_Prostate_Gland	Invasive_Adenocarcinoma_of_the_Mouse_Prostate_Gland	Moderately Differentiated Invasive Adenocarcinoma of the Mouse Prostate Gland|Moderately Differentiated Invasive Adenocarcinoma of the Prostate Gland|Moderately differentiated Invasive Adenocarcinoma	Combined glandular formation as well as foci of fusion/solid areas.
C21741	Poorly_Differentiated_Invasive_Adenocarcinoma_of_the_Mouse_Prostate_Gland	Invasive_Adenocarcinoma_of_the_Mouse_Prostate_Gland	Poorly Differentiated Invasive Adenocarcinoma of the Mouse Prostate Gland|Poorly Differentiated Invasive Adenocarcinoma of the Prostate Gland|Poorly differentiated Invasive Adenocarcinoma	Cytologic features suggestive of adenocarcinoma (e.g., secretory vacuoles, abundant clear or granular cytoplasm and prominent nucleoli); features of secretory differentiation on special stains; but no histologic glandular formation.
C21742	Undifferentiated_Invasive_Carcinoma_of_the_Mouse_Prostate_Gland	Invasive_Carcinoma_of_the_Mouse_Prostate_Gland|Mouse_Undifferentiated_Carcinoma	Undifferentiated Invasive Carcinoma of the Mouse Prostate Gland|Invasive carcinoma NOS|Undifferentiated Invasive Carcinoma|Undifferentiated Invasive Carcinoma of the Prostate Gland	Invasive carcinoma not showing glandular or NE differentiation or sarcomatoid morphology.
C21743	Invasive_Neuroendocrine_Carcinoma_of_the_Mouse_Prostate_Gland	Invasive_Carcinoma_of_the_Mouse_Prostate_Gland	Invasive Neuroendocrine Carcinoma of the Mouse Prostate Gland|Invasive Neuroendocrine Carcinoma of the Prostate Gland|Invasive Neuroendocrine carcinoma	Including solid and rosetting, with scant to moderate cytoplasm, nuclear features of NE carcinoma or with immunophenotypic documentation
C21744	Invasive_Small_Cell_Carcinoma_of_the_Mouse_Prostate_Gland	Invasive_Neuroendocrine_Carcinoma_of_the_Mouse_Prostate_Gland|Mouse_Small_Cell_Undifferentiated_Carcinoma	Invasive Small Cell Carcinoma of the Mouse Prostate Gland|Invasive Small Cell Carcinoma of the Prostate Gland|Invasive Small cell carcinoma	Invasive malignant epithelial neoplasm characterized by cells with scant cytoplasm and hyperchromatic nuclei, which may show molding and chromatin streaming around blood vessels (Azzopardi effect).
C21745	Spindle_Cell_Sarcomatoid_Carcinoma_of_the_Mouse_Prostate_Gland	Invasive_Carcinoma_of_the_Mouse_Prostate_Gland|Mouse_Spindle_Cell_Neoplasm	Spindle Cell / Sarcomatoid Carcinoma of the Mouse Prostate Gland|Spindle Cell / Sarcomatoid Carcinoma of the Prostate Gland|Spindle Cell/sarcomatoid Carcinoma	Distinguished from sarcoma by extensive CK immunoexpression and/or EM documentation of epithelial differentiation; lack of characteristic features of a specific sarcoma
C21746	Squamous_Cell_Carcinoma_of_the_Mouse_Prostate_Gland	Invasive_Carcinoma_of_the_Mouse_Prostate_Gland|Mouse_Squamous_Cell_Carcinoma	Squamous Cell Carcinoma of the Mouse Prostate Gland|Squamous Cell Carcinoma (MMY0057)|Squamous Cell Carcinoma of the Prostate Gland	Invasive malignant neoplasm which shows light microscopic features of squamous differentiation, typically in the form of keratinization and/or intercellular bridges.
C21747	Adenosquamous_Cell_Carcinoma_of_the_Mouse_Prostate_Gland	Invasive_Carcinoma_of_the_Mouse_Prostate_Gland|Mouse_Adenosquamous_Carcinoma	Adenosquamous Cell Carcinoma of the Mouse Prostate Gland|Adenosquamous Cell Carcinoma of the Prostate Gland|Adenosquamous cell carcinoma	Invasive malignant neoplasm that shows an admixture of foci of squamous differentiation with foci of glandular differentiation.
C21748	Sarcoma_of_the_Mouse_Prostate_Gland	Malignant_Neoplasms_of_the_Mouse_Prostate_Gland|Mouse_Sarcoma	Sarcoma of the Mouse Prostate Gland|Sarcoma|Sarcoma of the Prostate Gland	Malignant soft tissue tumor that arises from or differentiates towards prostatic stroma or specific differentiated mesenchymal tissue.
C21749	Leiomyosarcoma_of_the_Mouse_Prostate_Gland	Mouse_Leiomyosarcoma|Sarcoma_of_the_Mouse_Prostate_Gland	Leiomyosarcoma of the Mouse Prostate Gland|Leiomyosarcoma (MMY0060)|Leiomyosarcoma of the Prostate Gland
C21750	Rhabdomyosarcoma_of_the_Mouse_Prostate_Gland	Mouse_Rhabdomyosarcoma|Sarcoma_of_the_Mouse_Prostate_Gland	Rhabdomyosarcoma of the Mouse Prostate Gland|Rhabdomyosarcoma (MMY0061)|Rhabdomyosarcoma of the Prostate Gland
C21751	Chondrosarcoma_of_the_Mouse_Prostate_Gland	Mouse_Chondrosarcoma|Sarcoma_of_the_Mouse_Prostate_Gland	Chondrosarcoma of the Mouse Prostate Gland|Chondrosarcoma|Chondrosarcoma of the Prostate Gland
C21752	Osteosarcoma_of_the_Mouse_Prostate_Gland	Mouse_Osteosarcoma|Sarcoma_of_the_Mouse_Prostate_Gland	Osteosarcoma of the Mouse Prostate Gland|Osteosarcoma|Osteosarcoma of the Prostate Gland
C21753	Sarcoma_NOS_of_the_Mouse_Prostate_Gland	Sarcoma_of_the_Mouse_Prostate_Gland	Sarcoma NOS of the Mouse Prostate Gland|Sarcoma NOS of the Prostate Gland|Sarcoma, NOS	Including MFH-like
C21754	Carcinosarcoma_of_the_Mouse_Prostate_Gland	Malignant_Neoplasms_of_the_Mouse_Prostate_Gland|Mouse_Carcinoma|Mouse_Malignant_Mixed_Mesodermal_Tumor	Carcinosarcoma of the Mouse Prostate Gland|Carcinosarcoma|Carcinosarcoma of the Prostate Gland	Biphasic lesion which areas of unequivocal carcinoma and unequivocal sarcoma are present.
C21755	Mouse_Primary_Pulmonary_Tumors	Retired_Concepts	Murine Primary Pulmonary Tumors|Primary Pulmonary Tumors|Primary Pulmonary Tumors of the Mouse
C21756	Hyperplasia_of_the_Mouse_Pulmonary_System	Epithelial_Proliferative_Lesions_of_the_Mouse_Pulmonary_System|Mouse_Cancer-Related_Conditions	Hyperplasia of the Mouse Pulmonary System|Hyperplasia|Hyperplasia of the Pulmonary System	Increase in number of cells without atypia.
C21757	Epithelial_Hyperplasia_of_the_Mouse_Pulmonary_System	Hyperplasia_of_the_Mouse_Pulmonary_System	Epithelial Hyperplasia of the Mouse Pulmonary System|Epithelial Hyperplasia|Epithelial Hyperplasia of the Pulmonary System	Increase in number of cuboidal, columnar, ciliated or mucous cells without atypia.  Cells are single-layered and maintain normal architecture of bronchioles and alveoli.  The main distinctive features of regenerative hyperplasia are absence of direct link to tumor progression, and presence of inflammation and necrosis due to the inflicting toxic agent.
C21758	Neuroendocrine_Hyperplasia_of_the_Mouse_Pulmonary_System	Hyperplasia_of_the_Mouse_Pulmonary_System	Neuroendocrine Hyperplasia of the Mouse Pulmonary System|Neuroendocrine Hyperplasia|Neuroendocrine Hyperplasia of the Pulmonary System	Groups of uniform small cells with scant cytoplasm and round to oval nuclei with dense speckled chromatin form clusters thickening bronchiolar wall and/or protruding into the lumen.  Not reported to occur spontaneously.  Neuroendocrine hyperplasia must be differentiated from normal groups of neuroendocrine cells found more prominently in some mouse strains.
C21759	Epithelial_Tumors_of_the_Murine_Pulmonary_System	Retired_Concepts	Epithelial Tumors of the Murine Pulmonary System|Epithelial Tumors of the Pulmonary System|Epithelial tumors
C21760	Benign_Tumors_of_the_Mouse_Pulmonary_System	Tumors_of_the_Mouse_Pulmonary_System	Benign Tumors of the Mouse Pulmonary System|Benign Tumors|Benign Tumors of the Pulmonary System
C21761	Papilloma_of_the_Mouse_Pulmonary_System	Benign_Tumors_of_the_Mouse_Pulmonary_System|Mouse_Papilloma	Papilloma of the Mouse Pulmonary System|Papilloma of the Pulmonary System|Papillomas	Papillary structures lined with cuboidal respiratory epithelium containing connective tissue core.  Arises from the airway epithelium.
C21762	Adenoma_of_the_Mouse_Pulmonary_System	Benign_Tumors_of_the_Mouse_Pulmonary_System|Mouse_Adenoma	Adenoma of the Mouse Pulmonary System|Adenoma|Adenoma of the Pulmonary System	Among features indicating benign character are a small size, and absence of vascular invasion. Well delineated demarcation and absence of lepidic growth are considered by some as indicators of a benign character. Bland character of nuclei is a main feature of human adenomas. By this criterion many mouse adenomas could be assigned to adenocarcinomas. However, unlike in humans, mouse tumors are rarely metastatic during the time of their observation.
C21763	Papillary_Adenoma_of_the_Mouse_Pulmonary_System	Adenoma_of_the_Mouse_Pulmonary_System	Papillary Adenoma of the Mouse Pulmonary System|Papillary Adenoma|Papillary Adenoma of the Pulmonary System	Consists primarily of papillary structures lined by cuboidal to columnar cells. Cells forming papillary structures are frequently more hyperchromatic and atypical, which is regarded as indication of potential progression towards malignancy.
C21764	Solid_Adenoma_of_the_Mouse_Pulmonary_System	Adenoma_of_the_Mouse_Pulmonary_System	Solid Adenoma of the Mouse Pulmonary System|Solid Adenoma|Solid Adenoma of the Pulmonary System	Round to oval cells fill alveolar spaces. Fixation of the lung without inflation results in predominance of solid over alveolar pattern. Cells usually have abundant eosinophilic cytoplasm with fine granularity and /or vacuoles.
C21765	Adenoma_of_the_Mouse_Pulmonary_System_with_Mixed_Subtypes	Adenoma_of_the_Mouse_Pulmonary_System	Adenoma of the Mouse Pulmonary System with Mixed Subtypes|Adenoma of the Pulmonary System with Mixed Subtypes|Adenoma with mixed subtypes	Both papillary and solid structures are present.
C21766	Preinvasive_Lesions_of_the_Mouse_Pulmonary_System	Epithelial_Proliferative_Lesions_of_the_Mouse_Pulmonary_System|Mouse_Cancer-Related_Conditions	Preinvasive Lesions of the Mouse Pulmonary System|Preinvasive Lesions|Preinvasive Lesions of the Pulmonary System	This definition is for allocation of lesions with preinvasive/borderline properties. It is currently aimed at newly identified neoplasms, which may be similar to those described in humans. In mouse pathology, many adenomas may be preinvasive/borderline lesions. However, their inclusion in the preinvasive category can be justified only upon development of better diagnostic criteria.
C21767	Squamous_Dysplasia_of_the_Mouse_Pulmonary_System	Preinvasive_Lesions_of_the_Mouse_Pulmonary_System	Squamous Dysplasia of the Mouse Pulmonary System|Squamous Dysplasia of the Pulmonary System|Squamous dysplasia	Composed of airway epithelial cells with squamous metaplasia. Degree of atypia, maturation, orientation towards the basal membrane and involvement of full thickness of mucosa may vary.
C21768	Atypical_Adenomatous_Hyperplasia_of_the_Mouse_Pulmonary_System	Preinvasive_Lesions_of_the_Mouse_Pulmonary_System	Atypical Adenomatous Hyperplasia of the Mouse Pulmonary System|Atypical Adenomatous Hyperplasia of the Pulmonary System|Atypical adenomatous hyperplasia	Focal and diffuse lesions involving alveoli and respiratory bronchioles and consisting of relatively uniform atypical cuboidal to columnar cells with dense chromatin. Degrees of cellular hypertrophy and hyperchromasia are variable. Cellular and nuclear atypia are the distinctive features as compared to hyperplasia. Their relevance to human AAH and mouse adenomas remains to be determined.
C21769	Malignant_Tumors_of_the_Mouse_Pulmonary_System	Tumors_of_the_Mouse_Pulmonary_System	Malignant Tumors of the Mouse Pulmonary System|Malignant Tumors of the Pulmonary System	Main criteria for malignancy include size over 5 mm in diameter, invasion of airways, blood or lymphatic vessels, regional and distant metastasis, and ability to grow upon transplantation. Nuclear and cellular atypia, and loss of architecture should be considered as ancillary criteria for defining malignancy.
C21770	Squamous_Cell_Carcinoma_of_the_Mouse_Pulmonary_System	Malignant_Tumors_of_the_Mouse_Pulmonary_System|Mouse_Squamous_Cell_Carcinoma	Squamous Cell Carcinoma of the Mouse Pulmonary System|Squamous Cell Carcinoma of the Pulmonary System	The hallmarks of squamous cell carcinoma are the differentiation features of the squamous epithelium: keratinization and intercellular bridges. Large central masses of keratin, individual cell keratinization, and/or keratin pearls may form. Necrosis of tumor cell nests and accumulation of acute inflammatory cells are frequent features of poorly differentiated squamous cell carcinoma.
C21771	Adenocarcinoma_of_the_Mouse_Pulmonary_System	Malignant_Tumors_of_the_Mouse_Pulmonary_System|Mouse_Adenocarcinoma	Adenocarcinoma of the Mouse Pulmonary System|Adenocarcinoma of the Pulmonary System	Compared to adenomas, adenocarcinomas show greater cytological atypia, increased frequency of mitoses, regional variation in growth pattern, more papillary structures, have size over 5 mm in diameter, show invasion of vessels, large airways or pleura, as well as lymphatic and hematogenous metastases.
C21772	Papillary_Adenocarcinoma_of_the_Mouse_Pulmonary_System	Adenocarcinoma_of_the_Mouse_Pulmonary_System	Papillary Adenocarcinoma of the Mouse Pulmonary System|Papillary Adenocarcinoma of the Pulmonary System	Papillae have fibrovascular core lined by cuboidal to columnar cells with varying degree of pleomorphism.
C21773	Acinar_Adenocarcinoma_of_the_Mouse_Pulmonary_System	Adenocarcinoma_of_the_Mouse_Pulmonary_System|Mouse_Acinar_Cell_Neoplasm	Acinar Adenocarcinoma of the Mouse Pulmonary System|Acinar Adenocarcinoma|Acinar Adenocarcinoma of the Pulmonary System	Composed of predominately glandular structures, lined by cuboidal to tall cells, sometimes with mucous production. Cases with significant squamous or neuroendocrine component should be allocated to squamous cell or neuroendocrine carcinoma, respectively.
C21774	Solid_Adenocarcinoma_of_the_Mouse_Pulmonary_System	Adenocarcinoma_of_the_Mouse_Pulmonary_System	Solid Adenocarcinoma of the Mouse Pulmonary System|Solid Adenocarcinoma of the Pulmonary System	Uniformly solid character of the lesions is usually indicative of a well-differentiated tumor. No solid adenocarcinomas were observed in our series. However, rare cases have been described by others. In human pathology this diagnosis is usually based on detection of mucin after PAS digestion.
C21775	Adenocarcinoma_with_Mixed_Subtypes_of_the_Mouse_Pulmonary_System	Adenocarcinoma_of_the_Mouse_Pulmonary_System	Adenocarcinoma with Mixed Subtypes of the Mouse Pulmonary System|Adenocarcinoma with Mixed Subtypes of the Pulmonary System	Consists of various combinations of papillary, acinar and solid structures.
C21776	Adenocarcinoma_NOS_of_the_Mouse_Pulmonary_System	Adenocarcinoma_of_the_Mouse_Pulmonary_System	Adenocarcinoma NOS of the Mouse Pulmonary System|Adenocarcinoma NOS of the Pulmonary System	Tumors with glandular components but distinct from any other adenocarcinoma. This subgroup can be used for temporary allocation of novel lesions.
C21777	Adenosquamous_Carcinoma_of_the_Mouse_Pulmonary_System	Malignant_Tumors_of_the_Mouse_Pulmonary_System|Mouse_Adenosquamous_Carcinoma	Adenosquamous Carcinoma of the Mouse Pulmonary System|Adenosquamous Carcinoma of the Pulmonary System	Composed of both adenocarcinoma and malignant squamous components in equal or almost equal proportions. Keratinization is common.
C21778	Neuroendocrine_Carcinoma_of_the_Mouse_Pulmonary_System	Malignant_Tumors_of_the_Mouse_Pulmonary_System	Neuroendocrine Carcinoma of the Mouse Pulmonary System|Neuroendocrine Carcinoma of the Pulmonary System	This is a composite group consisting of tumors, in which neuroendocrine differentiation has been confirmed by immunohistochemical detection of such proteins as synaptophysin, CGRP and chromogranin. These tumors have only recently been described in mice. Their morphology varies from typical acinar pattern formation to more palisade-like structures to poorly differentiated neoplasms consisting of small hyperchromatic cells with minimal cytoplasm. Their relevance to human small cell carcinomas and other neuroendocrine carcinomas remains to be determined.
C21779	Carcinoma_Other_of_the_Mouse_Pulmonary_System	Malignant_Tumors_of_the_Mouse_Pulmonary_System|Mouse_Carcinoma	Carcinoma, Other, of the Mouse Pulmonary System|Carcinoma, Other, of the Pulmonary System|Other Carcinoma of the Mouse Pulmonary System	Usually, this category includes carcinomas without definitive diagnoses due to a small amount of material, or its low quality. Novel tumors, which are not completely characterized, can be temporarily allocated to this category. Caution needs to be taken to differentiate primary lung tumors from pulmonary metastases from other tumor sites.
C21780	Neoplasms_of_the_Mouse_Skin	Mouse_Integumentary_System_Neoplasms|Mouse_Skin_Disorder	Neoplasms of the Mouse Skin|Neoplasms and Proliferations of the Mouse Skin|Neoplasms and proliferations of the skin|Neoplasms of the Skin
C21781	Mouse_Melanocytic_Neoplasms_and_Proliferations	Mouse_Melanocyte_Neoplasm|Neoplasms_of_the_Mouse_Skin	Mouse Melanocytic Neoplasms and Proliferations|Melanocytic Neoplasms and Proliferations|Melanocytic neoplasms and proliferations	An increase in the number of melanocytes for a given anatomic site.
C21782	Melanocytic_Proliferative_Disorders_of_Mouse	Mouse_Cancer-Related_Conditions|Mouse_Skin_Disorder	Melanocytic Proliferative Disorders of Mouse|Melanocytic Proliferative Disorders|Melanocytic proliferative disorders	Melanocytes are present in excess at a given tissue site.
C21783	Junctional_Melanocytic_Hyperplasia_of_Mouse	Melanocytic_Proliferative_Disorders_of_Mouse	Junctional Melanocytic Hyperplasia of Mouse|Junctional Melanocytic Hyperplasia|Junctional melanocytic hyperplasia	Melanocytes are present in excess at the dermal/epidermal junction
C21784	Dermal_Melanocytic_Hyperplasia_of_Mouse	Melanocytic_Proliferative_Disorders_of_Mouse	Dermal Melanocytic Hyperplasia of Mouse|Dermal Melanocytic Hyperplasia|Dermal melanocytic hyperplasia	Melanocytes are present in excess in the dermis
C21785	Compound_Melanocytic_Hyperplasia_of_Mouse	Melanocytic_Proliferative_Disorders_of_Mouse	Compound Melanocytic Hyperplasia of Mouse|Compound Melanocytic Hyperplasia|Compound melanocytic hyperplasia	Melanocytes are present in excess at the dermal/epidermal junction and within the dermis
C21786	Mouse_Benign_Melanocytic_Neoplasms	Mouse_Melanocytic_Neoplasms_and_Proliferations	Mouse Benign Melanocytic Neoplasms|Benign Melanocytic Neoplasms|Benign melanocytic neoplasms	A clonal proliferation of melanocytes without significant potential for locally aggressive growth or metastasis.
C21787	Mouse_Melanocytoma	Mouse_Benign_Melanocytic_Neoplasms	Mouse Melanocytoma|Melanocytoma|blue nevus, benign melanoma	A benign melanocytic neoplasm composed of epithelioid melanocytes with a low nuclear/cytoplasmic ratio and usually containing extensive pigment in non-albino mice.
C21788	Mouse_Melanocytic_Neoplasms_of_Uncertain_Malignant_Potential	Mouse_Melanocytic_Neoplasms_and_Proliferations	Mouse Melanocytic Neoplasms of Uncertain Malignant Potential|Melanocytic Neoplasms of Uncertain Malignant Potential|Melanocytic neoplasms of uncertain malignant potential	Melanocytic neoplasms and are not clearly benign or malignant. Melanocytic neoplasms that occasionally but infrequently exhibit malignant characteristics fall into this category.
C21789	Mouse_Malignant_Melanocytic_Neoplasms	Mouse_Melanocytic_Neoplasms_and_Proliferations	Mouse Malignant Melanocytic Neoplasms|Malignant Melanocytic Neoplasms|Malignant melanocytic neoplasms	A clonal proliferation of melanocytes with significant potential for locally aggressive growth or metastasis.
C21790	Mouse_Melanoma	Mouse_Malignant_Melanocytic_Neoplasms	Mouse Melanoma|Melanoma	A malignant tumor composed of melanocytes, frequently exhibiting elevated mitotic activity, pleomorphism, tumor necrosis, and/or metastasis.
C21791	Mouse_Epithelioid_Melanoma	Mouse_Melanoma	Mouse Epithelioid Melanoma|Epithelioid Melanoma	A melanoma composed of cells with rounded nuclear and cytoplasmic contours (epithelioid cytology).
C21792	Mouse_Amelanotic_Epithelioid_Melanoma	Mouse_Epithelioid_Melanoma	Mouse Amelanotic Epithelioid Melanoma|Amelanotic Epithelioid Melanoma	A melanoma composed of cells with rounded nuclear and cytoplasmic contours (epithelioid cytology) that lacks melanin pigment.
C21793	Mouse_Spindle-cell_Melanoma	Mouse_Melanoma|Mouse_Spindle_Cell_Neoplasm	Mouse Spindle-cell Melanoma|Spindle-cell Melanoma	A melanoma composed of cells with elongated nuclear and cytoplasmic contours (spindle cell cytology).
C21794	Mouse_Amelanotic_Spindle-cell_Melanoma	Mouse_Spindle-cell_Melanoma	Mouse Amelanotic Spindle-cell Melanoma|Amelanotic Spindle-cell Melanoma	A melanoma composed of cells with elongated nuclear and cytoplasmic contours (spindle cell cytology) that lacks melanin pigment.
C21795	Mouse_Spindle_and_Epithelioid_Melanoma	Mouse_Melanoma	Mouse Spindle and Epithelioid Melanoma|Spindle and Epithelioid Melanoma|Spindle and epithelioid Melanoma	A melanoma composed of cells with both rounded and elongated nuclear and cytoplasmic contours (spindle and epithelioid cytology).
C21796	Mouse_Amelanotic_Spindle_and_Epithelioid_Melanoma	Mouse_Spindle_and_Epithelioid_Melanoma	Mouse Amelanotic Spindle and Epithelioid Melanoma|Amelanotic Spindle and Epithelioid Melanoma|Amelanotic Spindle and epithelioid Melanoma	A melanoma composed of cells with both rounded and elongated nuclear and cytoplasmic contours (spindle and epithelioid cytology) that lacks melanin pigment.
C21797	Other_Mouse_Melanoma	Mouse_Melanoma	Other Mouse Melanoma|Other Melanoma	A malignant tumor composed of melanocytes that does not fall within the above subclasses of melanoma.
C21798	Squamous_Neoplasms_of_the_Mouse_Skin	Mouse_Squamous_Cell_Neoplasm|Neoplasms_of_the_Mouse_Skin	Squamous Neoplasms of the Mouse Skin|Squamous Neoplasms and Proliferations of the Mouse Skin|Squamous Neoplasms of the Skin|Squamous neoplasms and proliferations	A clonal proliferation of keratinocytes in the skin.
C21799	Squamous_Proliferative_Disorders_of_the_Mouse_Skin	Mouse_Cancer-Related_Conditions|Mouse_Skin_Disorder	Squamous Proliferative Disorders of the Mouse Skin|Squamous Proliferative Disorders of the Skin|Squamous proliferative disorders	An increase in the number of keratinocytes composing the epidermis, usually involving an increase in the number of layers of keratinocytes.
C21800	Squamous_Hyperplasia_of_the_Mouse_Skin	Squamous_Proliferative_Disorders_of_the_Mouse_Skin	Squamous Hyperplasia of the Mouse Skin|Squamous Hyperplasia of the Skin|Squamous hyperplasia	An increase in the number of keratinocytes composing the epidermis usually with thickening of the epidermis.
C21801	Squamous_Hyperplasia_of_the_Mouse_Skin_with_Atypia	Squamous_Proliferative_Disorders_of_the_Mouse_Skin	Squamous Hyperplasia of the Mouse Skin with Atypia|Squamous Hyperplasia of the Skin with Atypia|Squamous hyperplasia with aytpia	An increase in the number of keratinocytes composing the epidermis with significant cytologic atypia of keratinocytes. Criteria for atypia include increase in cell size (>1.5 fold nuclear enlargement relation to basal keratinocytes), hyperchromasia, and crowding of basal keratinocytes.
C21802	Benign_Squamous_Neoplasms_of_the_Mouse_Skin	Squamous_Neoplasms_of_the_Mouse_Skin	Benign Squamous Neoplasms of the Mouse Skin|Benign Squamous Neoplasms of the Skin|Benign squamous neoplasms	A clonal proliferation of keratinocytes in the skin that lacks locally invasive growth and metastases.
C21803	Papilloma_of_the_Mouse_Skin	Benign_Squamous_Neoplasms_of_the_Mouse_Skin	Papilloma of the Mouse Skin|Papilloma (MMS0015)|Papilloma of the Skin	Polypoid squamous lesion without evidence of invasion or desmoplasia. Lesions with a crateriform growth pattern on a polypoid stalk have occasionally been diagnosed as keratoacanthoma. The pathology panel recommends avoiding the use of the diagnosis of keratoacanthoma, as it has been applied to a variety of lesions (papillomas, well differentiated squamous cell carcinoma with a crateriform growth pattern and certain breast lesions).
C21804	Benign_Basal_Cell_Tumor_of_the_Mouse_Skin	Mouse_Basal_Cell_Neoplasm|Squamous_Neoplasms_of_the_Mouse_Skin	Benign Basal Cell Tumor of the Mouse Skin|Benign Basal Cell Tumor of the Skin|Benign basal cell tumor	A cutaneous neoplasm composed of cells with basaloid cytology that does not exhibit significant follicular differentiation and is not locally invasive or metastatic.
C21805	Squamous_Cell_Carcinoma_in_Situ_of_the_Mouse_Skin	Squamous_Neoplasms_of_the_Mouse_Skin	Squamous Cell Carcinoma in Situ of the Mouse Skin|Squamous Cell Carcinoma in Situ of the Skin|Squamous cell carcinoma in situ	A neoplasm of keratinocytes resulting in full-thickness epidermal nuclear atypia.
C21806	Squamous_Cell_Carcinoma_of_the_Mouse_Skin	Mouse_Squamous_Cell_Carcinoma|Squamous_Neoplasms_of_the_Mouse_Skin	Squamous Cell Carcinoma of the Mouse Skin|Squamous Cell Carcinoma of the Skin|Squamous cell carcinoma (MMS0018)	A neoplasm of keratinocytes with local invasion and/or metastasis.
C21807	Well-differentiated_Squamous_Cell_Carcinoma_of_the_Mouse_Skin	Squamous_Cell_Carcinoma_of_the_Mouse_Skin	Well-differentiated Squamous Cell Carcinoma of the Mouse Skin|Well-differentiated Squamous Cell Carcinoma of the Skin|Well-differentiated squamous cell carcinoma	A neoplasm of keratinocytes with local invasion and/or metastasis with evidence of keratinization apparent in greater than 2/3 of the neoplasm.
C21808	Moderately-differentiated_Squamous_Cell_Carcinoma_of_the_Mouse_Skin	Squamous_Cell_Carcinoma_of_the_Mouse_Skin	Moderately-differentiated Squamous Cell Carcinoma of the Mouse Skin|Moderately-differentiated Squamous Cell Carcinoma of the Skin|Moderately-differentiated squamous cell carcinoma	A neoplasm of keratinocytes with local invasion and/or metastasis with evidence of keratinization apparent in greater than 1/3 of the neoplasm but less than 2/3 of the neoplasm.
C21809	Poorly-differentiated_Squamous_Cell_Carcinoma_of_the_Mouse_Skin	Squamous_Cell_Carcinoma_of_the_Mouse_Skin	Poorly-differentiated Squamous Cell Carcinoma of the Mouse Skin|Poorly-differentiated Squamous Cell Carcinoma of the Skin|Poorly-differentiated squamous cell carcinoma	A neoplasm of keratinocytes with local invasion and/or metastasis with little to no evidence of keratinization. Marked nuclear atypia may be present.
C21810	Spindle-cell_Squamous_Cell_Carcinoma_of_the_Mouse_Skin	Mouse_Spindle_Cell_Neoplasm|Poorly-differentiated_Squamous_Cell_Carcinoma_of_the_Mouse_Skin	Spindle-cell Squamous Cell Carcinoma of the Mouse Skin|Spindle-cell Squamous Cell Carcinoma of the Skin|Spindle-cell squamous cell carcinoma	A variant of poorly-differentiated squamous cell carcinoma predominantly composed of spindle cells. Attachment to overlying atypical squamous epithelium may be helpful for diagnosis. Spindle cell tumors that arise in UV irradiated or mice treated with topical chemical carcinogens that resemble so-called "fibrosarcoma" are very frequently spindle cell squamous carcinoma.
C21811	Malignant_Basal_Cell_Tumor_of_the_Mouse_Skin	Squamous_Neoplasms_of_the_Mouse_Skin	Malignant Basal Cell Tumor of the Mouse Skin|Malignant Basal Cell Tumor of the Skin|Malignant basal cell tumor	A cutaneous neoplasm composed of cells with basaloid cytology that does not exhibit significant follicular differentiation and that is locally invasive or metastatic. Strict diagnostic criteria should be applied for this rare murine tumor. Sheets of basaloid tumor cells with a well formed peripheral palisade and numerous apoptotic cells and mitotic figures should be present. Invasion of individual tumor nests is a supportive feature. Most tumors of this type do not appear to arise from the follicular epithelium in mice and do not the extensive follicular differentiation of the basaloid follicular neoplasms listed below. The relationship of malignant basal cell tumor and basaloid follicular neoplasms with human basal cell carcinomas is not well understood at present..
C21812	Adnexal_Neoplasms_of_the_Mouse_Skin	Neoplasms_of_the_Mouse_Skin	Adnexal Neoplasms of the Mouse Skin|Adnexal Neoplasms of the Skin|Adnexal neoplasms	Clonal proliferations arising from adnexal skin structures including hair follicles, and apocrine and eccrine glands and ducts.
C21813	Follicular_Neoplasms_of_the_Mouse_Skin	Adnexal_Neoplasms_of_the_Mouse_Skin	Follicular Neoplasms of the Mouse Skin|Follicular Neoplasms of the Skin|Follicular neoplasms	Clonal proliferations arising from cutaneous hair follicles.
C21814	Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Follicular_Neoplasms_of_the_Mouse_Skin	Basaloid Follicular Neoplasm of the Mouse Skin|Basaloid Follicular Neoplasm of the Skin|Basaloid follicular neoplasm	Clonal proliferations arising from cutaneous hair follicles composed in part of cells with basaloid cytology.
C21815	Pilomatrixoma_Type_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Pilomatrixoma Type of Basaloid Follicular Neoplasm of the Mouse Skin|Pilomatrixoma Type of Basaloid Follicular Neoplasm of the Skin|Pilomatrixoma type	Clonal proliferations arising from cutaneous hair follicles composed in part of cells with basaloid cytology that resemble human pilomatrixomas.
C21816	Trichoblastoma_Type_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Trichoblastoma Type of Basaloid Follicular Neoplasm of the Mouse Skin|Trichoblastoma Type of Basaloid Follicular Neoplasm of the Skin|Trichoblastoma type	Clonal proliferations arising from cutaneous hair follicles composed in part of cells with basaloid cytology that resemble human trichoblastomas.
C21817	Trichoepithelioma_Type_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Trichoepithelioma Type of Basaloid Follicular Neoplasm of the Mouse Skin|Trichoepithelioma Type of Basaloid Follicular Neoplasm of the Skin|Trichoepithelioma type	Clonal proliferations arising from cutaneous hair follicles composed in part of cells with basaloid cytology that resemble human trichoepitheliomas.
C21818	Trichofolliculoma_Type_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Trichofolliculoma Type of Basaloid Follicular Neoplasm of the Mouse Skin|Trichofolliculoma Type of Basaloid Follicular Neoplasm of the Skin|Trichofolliculoma type	Clonal proliferations arising from cutaneous hair follicles composed in part of cells with basaloid cytology that resemble human trichofolliculoma.
C21819	Cylindroma_Type_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Cylindroma Type of Basaloid Follicular Neoplasm of the Mouse Skin|Cylindroma Type of Basaloid Follicular Neoplasm of the Skin|Cylindroma type	Clonal proliferations arising from cutaneous hair follicles composed in part of cells with basaloid cytology that resemble human cylindromas.
C21820	Spiradenoma_Type_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Spiradenoma Type of Basaloid Follicular Neoplasm of the Mouse Skin|Spiradenoma Type of Basaloid Follicular Neoplasm of the Skin|Spiradenoma type	Clonal proliferations arising from cutaneous hair follicles composed in part of cells with basaloid cytology that resemble human spiradenomas.
C21821	Superficial_Basal_Cell_Carcinoma_Type_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Superficial Basal Cell Carcinoma Type of Basaloid Follicular Neoplasm of the Mouse Skin|Superficial Basal Cell Carcinoma Type of Basaloid Follicular Neoplasm of the Skin|Superficial basal cell carcinoma type	Clonal proliferations arising from cutaneous hair follicles or adjacent skin composed in part of cells with basaloid cytology that resemble human superficial basal cell carcinomas.
C21822	Other_Variants_of_Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Basaloid_Follicular_Neoplasm_of_the_Mouse_Skin	Other Variants of Basaloid Follicular Neoplasm of the Mouse Skin|Other Variants of Basaloidi Follicular Neoplasm of the Skin|Other variants	Clonal proliferations arising from cutaneous hair follicles composed in part of cells with basaloid cytology that exhibit features of hair follicle differentiation but are not easily classified as one of the above variants.
C21823	Sebaceous_Neoplasms_and_Hyperplasias_of_the_Mouse_Skin	Adnexal_Neoplasms_of_the_Mouse_Skin	Sebaceous Neoplasms and Hyperplasias of the Mouse Skin|Sebaceous Neoplasms and Hyperplasias of the Skin|Sebaceous neoplasms and hyperplasias	A proliferation of cells with sebaceous differentiation.
C21824	Sebaceous_Hyperplasia_of_the_Mouse_Skin	Mouse_Cancer-Related_Conditions|Mouse_Skin_Disorder	Sebaceous Hyperplasia of the Mouse Skin|Sebaceous Hyperplasia of the Skin|Sebaceous hyperplasia	Increased size and number of sebaceous glands for a given anatomic site, age, and mouse strain.
C21825	Sebaceous_Adenoma_of_the_Mouse_Skin	Mouse_Adenoma|Sebaceous_Neoplasms_and_Hyperplasias_of_the_Mouse_Skin	Sebaceous Adenoma of the Mouse Skin|Sebaceous Adenoma of the Skin|Sebaceous adenoma	A clonal proliferation of sebaceous cells with a lobular outline and without invasion or metastasis.
C21826	Sebaceous_Carcinoma_of_the_Mouse_Skin	Mouse_Carcinoma|Sebaceous_Neoplasms_and_Hyperplasias_of_the_Mouse_Skin	Sebaceous Carcinoma of the Mouse Skin|Sebaceous Carcinoma of the Skin|Sebaceous carcinoma	Clonal proliferation of sebaceous cells with significant cytological atypia and invasion or metastasis.
C21827	Mouse_Eccrine_Neoplasms	Adnexal_Neoplasms_of_the_Mouse_Skin	Mouse Eccrine Neoplasms|Eccrine Neoplasms|Eccrine neoplasms	A clonal proliferation of eccrine glandular or ductular cells.
C21828	Apocrine_Neoplasms_of_the_Mouse_Skin	Adnexal_Neoplasms_of_the_Mouse_Skin	Apocrine Neoplasms of the Mouse Skin|Apocrine Neoplasms of the Skin|Apocrine neoplasms	A clonal proliferation of apocrine glandular or ductular cells.
C21829	Mixed_Tumors_of_the_Mouse_Skin	Adnexal_Neoplasms_of_the_Mouse_Skin|Mouse_Mixed_Neoplasm	Mixed Tumors of the Mouse Skin|Mixed Tumors of the Skin|Mixed tumor	A clonal proliferation of cells frequently with a mixture of mesenchymal and epithelial patterns of differentiation.
C21830	Other_Adnexal_Neoplasms_of_the_Mouse_Skin	Adnexal_Neoplasms_of_the_Mouse_Skin	Other Adnexal Neoplasms of the Mouse Skin|Other Adnexal Neoplasms of the Skin|Other adnexal neoplasms	Clonal proliferations arising in adnexal structures that are not otherwise classifiable.
C21831	Benign_Mesenchymal_Neoplasms_of_the_Mouse_Skin	Neoplasms_of_the_Mouse_Skin	Benign Mesenchymal Neoplasms of the Mouse Skin|Benign Mesenchymal Neoplasms of the Skin|Benign mesenchymal neoplasms	A clonal proliferation of cells arising in cells of mesenchymal embryonic without significant invasion or metastasis.
C21832	Fibroma_of_the_Mouse_Skin	Benign_Mesenchymal_Neoplasms_of_the_Mouse_Skin|Mouse_Fibroma	Fibroma of the Mouse Skin|Fibroma (MMS0091)|Fibroma of the Skin	A clonal proliferation of bland spindle cells, usually well circumscribed and with some collagenous stroma.
C21833	Hemangioma_of_the_Mouse_Skin	Benign_Mesenchymal_Neoplasms_of_the_Mouse_Skin|Mouse_Angioma|Mouse_Primary_Tumors_of_the_Blood_Vessel	Hemangioma of the Mouse Skin|Hemangioma (MMS0092)|Hemangioma of the Skin	Excessive numbers of vessels resulting from a clonal proliferation of endothelial cells without significant invasion or metastasis.
C21834	Lipoma_of_the_Mouse_Skin	Benign_Mesenchymal_Neoplasms_of_the_Mouse_Skin|Mouse_Lipoma	Lipoma of the Mouse Skin|Lipoma (MMS0093)|Lipoma of the Skin	A clonal proliferation of adipocytes without significant invasion or metastasis.
C21835	Hibernoma_of_the_Mouse_Skin	Benign_Mesenchymal_Neoplasms_of_the_Mouse_Skin|Mouse_Hibernoma	Hibernoma of the Mouse Skin|Hibernoma|Hibernoma of the Skin	A clonal proliferation of multivacuolated adipocytes with centrally located nuclei without significant invasion or metastasis.
C21836	Schwannoma_of_the_Mouse_Skin	Benign_Mesenchymal_Neoplasms_of_the_Mouse_Skin|Mouse_Neuroglia_Neoplasm	Schwannoma of the Mouse Skin|Schwannoma|Schwannoma of the Skin	A bland spindle cell neoplasm that arises in peripheral nerves with eccentric expansion for the nerve and strong S100 protein immunoperoxidase staining without significant invasion or metastasis.
C21837	Neurofibroma_of_the_Mouse_Skin	Benign_Mesenchymal_Neoplasms_of_the_Mouse_Skin|Mouse_Neurofibroma	Neurofibroma of the Mouse Skin|Neurofibroma|Neurofibroma of the Skin	A bland spindle cell neoplasm composed of several cell types including cells derived from the peripheral nerve sheath and fibroblasts without significant invasion or metastasis.
C21838	Myxoma_of_the_Mouse_Skin	Retired_Concepts	Myxoma of the Mouse Skin|Myxoma|Myxoma of the Skin
C21839	Granular_Cell_Tumor_of_the_Mouse_Skin	Benign_Mesenchymal_Neoplasms_of_the_Mouse_Skin|Mouse_Granular_Cell_Neoplasm	Granular Cell Tumor of the Mouse Skin|Granular Cell Tumor of the Skin|Granular cell tumor	A neoplasm of the skin composed of cells with markedly granular cytoplasm that exhibit strong S100 immunoperoxidase positivity.
C21840	Sarcomas_of_the_Mouse_Skin_and_Subcutis	Mouse_Sarcoma|Neoplasms_of_the_Mouse_Skin	Sarcomas of the Mouse Skin and Subcutis|Sarcomas of the Skin and Subcutis|Sarcomas of the skin and subcutis	Malignant neoplasms of the skin and subcutis that are composed of cells of mesenchymal origin.
C21841	Hemangiosarcoma_of_the_Mouse_Skin	Mouse_Angiosarcoma|Sarcomas_of_the_Mouse_Skin_and_Subcutis	Hemangiosarcoma of the Mouse Skin|Hemangiosarcoma (MMS0041)|Hemangiosarcoma of the Skin	Malignant neoplasms of the skin composed of atypical endothelial cells with poor formation of blood vessels.
C21842	Lymphangiosarcoma_of_the_Mouse_Skin	Mouse_Angiosarcoma|Sarcomas_of_the_Mouse_Skin_and_Subcutis	Lymphangiosarcoma of the Mouse Skin|Lymphangiosarcoma|Lymphangiosarcoma of the Skin	Malignant neoplasms of the skin composed of atypical lymphatic endothelial cells with poor formation of lymph vessels.
C21843	Malignant_Peripheral_Nerve_Sheath_Tumor_of_the_Mouse_Skin	Mouse_Neural_Cell_Neoplasm|Sarcomas_of_the_Mouse_Skin_and_Subcutis	Malignant Peripheral Nerve Sheath Tumor of the Mouse Skin|Malignant Peripheral Nerve Sheath Tumor of the Skin|Malignant peripheral nerve sheath tumor	Malignant neoplasm generally composed of spindle cells of peripheral nerve sheath derivation.
C21844	Leiomyosarcoma_of_the_Mouse_Skin	Mouse_Leiomyosarcoma|Sarcomas_of_the_Mouse_Skin_and_Subcutis	Leiomyosarcoma of the Mouse Skin|Leiomyosarcoma (MMS0043)|Leiomyosarcoma of the Skin	Malignant neoplasm generally composed of spindle cells that exhibit smooth muscle differentiation.
C21845	Rhabdomyosarcoma_of_the_Mouse_Skin	Mouse_Rhabdomyosarcoma|Sarcomas_of_the_Mouse_Skin_and_Subcutis	Rhabdomyosarcoma of the Mouse Skin|Rhabdomyosarcoma (MMS0044)|Rhabdomyosarcoma of the Skin	Malignant neoplasm generally composed of spindle cells that exhibit skeletal muscle differentiation.
C21846	Liposarcoma_of_the_Mouse_Skin	Mouse_Liposarcoma|Sarcomas_of_the_Mouse_Skin_and_Subcutis	Liposarcoma of the Mouse Skin|Liposarcoma (MMS0100)|Liposarcoma of the Skin	Malignant neoplasm generally composed of spindle cells that exhibit skeletal muscle differentiation.
C21847	Unclassified_Malignant_Spindle_Cell_Neoplasm_of_the_Mouse_Skin	Mouse_Spindle_Cell_Neoplasm|Sarcomas_of_the_Mouse_Skin_and_Subcutis	Unclassified Malignant Spindle Cell Neoplasm of the Mouse Skin|Malignant spindle cell neoplasm, unclassified|Unclassified Malignant Spindle Cell Neoplasm of the Skin	Malignant spindle cell neoplasm of the skin that cannot be classified into other categories. This diagnostic term acknowledges that non-mesenchymal tumors including carcinomas and melanomas can also be malignant spindle cell neoplasms. The term fibrosarcoma is widely used for lesions of this morphology, but specific criteria for this term are vague and non-mesenchymal spindle cell tumors are rarely excluded.
C21848	Mouse_Cutaneous_Tumors_of_Hematompoetic_Origin	Neoplasms_of_the_Mouse_Skin	Mouse Cutaneous Tumors of Hematompoetic Origin|Cutaneous Tumors of Hematompoetic Origin|Cutaneous tumors of hematompoetic origin	Clonal proliferations that arise in the skin that are composed of cell types that originate in the hematopoietic system.
C21849	Mouse_Cutaneous_Lymphomas	Mouse_Cutaneous_Tumors_of_Hematompoetic_Origin|Mouse_Lymphoma	Mouse Cutaneous Lymphomas|Cutaneous Lymphomas|Cutaneous lymphomas	Lymphocytic neoplasms that arise in the skin.
C21850	B-cell_Lymphomas_of_the_Mouse_Skin	Mouse_B_Cell_Neoplasms|Mouse_Cutaneous_Lymphomas	B-cell Lymphomas of the Mouse Skin|B-cell Lymphomas of the Skin|B-cell lymphomas	B-lymphocytic neoplasms that arise in the skin.
C21851	T-cell_Lymphomas_of_the_Mouse_Skin	Mouse_Cutaneous_Lymphomas|Mouse_T_Cell_Neoplasms	T-cell Lymphomas of the Mouse Skin|T-cell Lymphomas of the Skin|T-cell lymphomas	T-lymphocytic neoplasms that arise in the skin.
C21852	Other_Lymphomas_of_the_Mouse_Skin	Mouse_Cutaneous_Lymphomas	Other Lymphomas of the Mouse Skin|Other Lymphomas of the Skin|Other lymphomas	Clonal lymphocytic proliferations that arise in the skin that cannot be easily classified as either B-lymphocytic or T-lymphocytic.
C21853	Plasma_Cell_Neoplasms_of_the_Mouse_Skin	Mouse_Cutaneous_Tumors_of_Hematompoetic_Origin|Mouse_Plasma_Cell_Neoplasm	Plasma Cell Neoplasms of the Mouse Skin|Plasma Cell Neoplasms of the Skin|Plasma cell neoplasms and proliferations	Clonal proliferations that arise in the skin that exhibit plasmacytic differentiation.
C21854	Benign_Plasma_Cell_Proliferations_of_the_Mouse_Skin	Mouse_Cancer-Related_Conditions|Mouse_Skin_Disorder	Benign Plasma Cell Proliferations of the Mouse Skin|Benign Plasma Cell Proliferations of the Skin|Benign plasma cell proliferations	Clonal proliferations that arise in the skin that exhibit plasmacytic differentiation and lack locally aggressive growth or metastasis.
C21855	Malignant_Plasmacytoma_of_the_Mouse_Skin	Mouse_Plasmacytoma|Plasma_Cell_Neoplasms_of_the_Mouse_Skin	Malignant Plasmacytoma of the Mouse Skin|Malignant Plasmacytoma of the Skin|Malignant plasmacytoma
C21856	Histiocytic_Neoplasms_of_the_Mouse_Skin	Mouse_Cutaneous_Tumors_of_Hematompoetic_Origin	Histiocytic Neoplasms of the Mouse Skin|Histiocytic Neoplasms of the Skin|Histiocytic neoplasms	Clonal proliferations that arise in the skin that have histiocytic differentiation (at present determined by F4/80 immunohistochemical staining).
C21857	Benign_Histiocytic_Neoplasms_of_the_Mouse_Skin	Histiocytic_Neoplasms_of_the_Mouse_Skin	Benign Histiocytic Neoplasms of the Mouse Skin|Benign Histiocytic Neoplasms of the Skin|Benign histiocytic neoplasms	Clonal proliferations that arise in the skin that have histiocytic differentiation and lack features of locally aggressive growth or metastasis.
C21858	Malignant_Histiocytic_Neoplasms_of_the_Mouse_Skin	Histiocytic_Neoplasms_of_the_Mouse_Skin	Malignant Histiocytic Neoplasms of the Mouse Skin|Malignant Histiocytic Neoplasms of the Skin|Malignant histiocytic neoplasms	Clonal proliferations that arise in the skin that have histiocytic differentiation with features of locally aggressive growth or metastasis.
C21859	Mast_Cell_Neoplasms_of_the_Mouse_Skin	Mouse_Cutaneous_Tumors_of_Hematompoetic_Origin|Mouse_Mast_Cell_Neoplasm	Mast Cell Neoplasms of the Mouse Skin|Mast Cell Neoplasms of the Skin|Mast cell neoplasms	Clonal mast cell proliferations that arise in the skin.
C21860	Mastocytoma_of_the_Mouse_Skin	Mast_Cell_Neoplasms_of_the_Mouse_Skin	Mastocytoma of the Mouse Skin|Mastocytoma|Mastocytoma of the Skin	Mast cell neoplasms arising in the skin.
C21861	Other_Cutaneous_Neoplasms_of_Hematopoetic_Origin_of_Mouse	Mouse_Cutaneous_Tumors_of_Hematompoetic_Origin	Other Cutaneous Neoplasms of Hematopoetic Origin of Mouse|Other Cutaneous Neoplasms of Hematopoetic Origin|Other cutaneous neoplasms of hematopoetic origin	Clonal proliferations arising in the skin or hematopoietic origin that cannot be otherwise classified.
C21862	Non-neoplastic_Disorders_of_the_Mouse_Skin	Mouse_Noncancerous_Conditions|Mouse_Skin_Disorder	Non-neoplastic Disorders of the Mouse Skin|Non-neoplastic Disorders of the Skin|Non-neoplastic disorders of the skin	An alteration in the normal structure of the skin relative to normal for a specific age, mouse strain, and skin site that does not involve a clonal proliferation of cells.
C21863	Disorders_of_the_Squamous_Epithelium_of_the_Mouse_Skin	Non-neoplastic_Disorders_of_the_Mouse_Skin	Disorders of the Squamous Epithelium of the Mouse Skin|Disorders of the Squamous Epithelium of the Skin|Disorders of the squamous epithelium	An alteration in the normal structure of the squamous epithelium relative to normal for a specific age, mouse strain, and skin site.
C21864	Disorders_of_Pigmentation_of_the_Mouse_Skin	Non-neoplastic_Disorders_of_the_Mouse_Skin	Disorders of Pigmentation of the Mouse Skin|Disorders of Pigmentation of the Skin|Disorders of pigmentation	An alteration in skin pigmentation relative to normal for a specific age, mouse strain, and skin site.
C21865	Disorders_of_the_Mouse_Hair_Follicle	Non-neoplastic_Disorders_of_the_Mouse_Skin	Disorders of the Mouse Hair Follicle|Disorders of the Hair Follicle|Disorders of the hair follicle	An alteration in the normal structure of the hair follicle relative to normal for a specific age, mouse strain, and skin site.
C21866	Follicular_Cyst_of_the_Mouse_Skin	Disorders_of_the_Mouse_Hair_Follicle	Follicular Cyst of the Mouse Skin|Follicular Cyst of the Skin|Follicular cyst	Cystic dilation of a hair follicle with retention of keratinaceous debris.
C21867	Non-Neoplastic_Hematopoietic_Disorders_of_Mouse	Mouse_Hematologic_Disorder|Mouse_Noncancerous_Conditions	Non-Neoplastic Hematopoietic Disorders of Mouse|Non-Neoplastic Hematopoietic Disorders
C21868	Non-Neoplastic_Non-Lymphoid_Hematopoietic_Disorders_of_Mouse	Non-Neoplastic_Hematopoietic_Disorders_of_Mouse	Non-Neoplastic Non-Lymphoid Hematopoietic Disorders of Mouse|Non-Neoplastic Non-Lymphoid Hematopoietic Disorders|Non-Neoplastic Non-lymphoid Disorders
C21869	Non-Neoplastic_Myeloid_Disorders_of_Mouse	Non-Neoplastic_Non-Lymphoid_Hematopoietic_Disorders_of_Mouse	Non-Neoplastic Myeloid Disorders of Mouse|Non-Neoplastic Myeloid Disorders	It can be noted if the lesion is pre-neoplastic
C21870	Non-Neoplastic_Splenic_Myeloid_Hyperplasia_of_Mouse	Non-Neoplastic_Myeloid_Disorders_of_Mouse	Non-Neoplastic Splenic Myeloid Hyperplasia of Mouse|Non-neoplastic Splenic Myeloid Hyperplasia|Non-neoplastic splenic myeloid hyperplasia	Comment: a mixture of immature granulocytic cells, erythroid precursors, and megakaryocytes are normally seen at a low level in mouse spleen; increased levels in spleen in hyperplasia, also maybe in liver, adrenals and nodes.
C21871	Mouse_Extramedullary_Hematopoiesis	Non-Neoplastic_Myeloid_Disorders_of_Mouse	Mouse Extramedullary Hematopoiesis|Extramedullary Hematopoiesis|Extramedullary hematopoiesis	Presence of a mixture of immature granulocytic cells, erythroid precursors, and megakaryocytes maybe seen in liver, adrenals and nodes.
C21872	Non-Neoplastic_Histiocytic_Disorders_of_Mouse	Non-Neoplastic_Non-Lymphoid_Hematopoietic_Disorders_of_Mouse	Non-Neoplastic Histiocytic Disorders of Mouse|Non-Neoplastic Histiocytic Disorders
C21873	Sinus_Histiocytosis_of_Mouse	Non-Neoplastic_Histiocytic_Disorders_of_Mouse	Sinus Histiocytosis of Mouse|Sinus Histiocytosis|Sinus histiocytosis	Increased numbers and/or size of sinus histiocytes in nodes.
C21874	Histiocytosis_in_Association_with_a_Hematopoietic_Neoplasm_of_Mouse	Non-Neoplastic_Histiocytic_Disorders_of_Mouse	Histiocytosis in Association with a Hematopoietic Neoplasm of Mouse|Histiocytosis in Association with a Hematopoietic Neoplasm|Histiocytosis in association with a hematopoietic neoplasm	Histiocytic foci within lymphomas, may represent early histiocytic sarcoma or histiocyte-associated DLBCL.
C21875	Non-Neoplastic_Mast_Cell_Disorders_of_the_Mouse_Hematologic_System	Non-Neoplastic_Non-Lymphoid_Hematopoietic_Disorders_of_Mouse	Non-Neoplastic Mast Cell Disorders of the Mouse Hematologic System|Non-Neoplastic Mast Cell Disorders|Non-Neoplastic Mast Cell Disorders of the Hematologic System
C21876	Mastocytosis_of_the_Mouse_Hematologic_System	Non-Neoplastic_Mast_Cell_Disorders_of_the_Mouse_Hematologic_System	Mastocytosis of the Mouse Hematologic System|Mastocytosis|Mastocytosis of the Hematologic System	Increased numbers of mast cells in specific tissues.
C21877	Non-neoplastic_Lymphoid_Disorders_of_the_Mouse_Hematologic_System	Non-Neoplastic_Hematopoietic_Disorders_of_Mouse	Non-neoplastic Lymphoid Disorders of the Mouse Hematologic System|Non-neoplastic Lymphoid Disorders of the Hematologic System|Non-neoplastic lymphoid disorders
C21878	Pre-lymphoma_Lymphoproliferative_Disorders_of_the_Mouse_Hematologic_System	Non-neoplastic_Lymphoid_Disorders_of_the_Mouse_Hematologic_System	Pre-lymphoma Lymphoproliferative Disorders of the Mouse Hematologic System|Pre-lymphoma Lymphoproliferative Disorders of the Hematologic System|Pre-lymphoma lymphoproliferative disorders
C21879	Fas_and_Fas_Ligand_Diseases_of_the_Mouse_Hematologic_System	Pre-lymphoma_Lymphoproliferative_Disorders_of_the_Mouse_Hematologic_System	Fas and Fas Ligand Diseases of the Mouse Hematologic System|Fas and Fas Ligand Diseases of the Hematologic System|Fas and Fas ligand diseases	Lymphoproliferative disease of spleen and nodes, no apoptosis, medium sized lymphocytes
C21880	SJL_Disease_of_the_Mouse_Hematologic_System	Pre-lymphoma_Lymphoproliferative_Disorders_of_the_Mouse_Hematologic_System	SJL Disease of the Mouse Hematologic System|SJL Disease of the Hematologic System|SJL disease	Mixed populations of lymphoid and other cells progressing to B-cell lymphoma with plasmacytoid features.
C21881	MAIDS	Pre-lymphoma_Lymphoproliferative_Disorders_of_the_Mouse_Hematologic_System	MAIDS	Retroviral disease from lymphoproliferative to lymphoma
C21882	Mouse_Hematologic_Neoplasms_and_Related_Disorders	Mouse_Hematologic_Disorder|Mouse_Neoplasms_by_Location	Mouse Hematologic Neoplasms and Related Disorders|Hematologic Neoplasms and Related Disorders
C21883	Non-Lymphoid_Hematopoietic_Neoplasm_of_Mouse	Mouse_Hematologic_Neoplasms_and_Related_Disorders	Non-Lymphoid Hematopoietic Neoplasm of Mouse|Non-lymphoid Hematopoietic Neoplasm|Non-lymphoid hematopoietic neoplasm	Disease analogous to kinds of human diseases in the WHO classification of human lymphoid and hematopoietic neoplasms; Genetically Determined; Meets criteria for Non-lymphoid leukemia, Non-lymphoid hematopoietic sarcoma, myeloid proliferation (non-reactive) or myeloid dysplasia; Neoplastic; Non-lymphoid or bi-phenotypic; Non-reactive; Persistent
C21884	Mouse_Non-lymphoid_Hematopoietic_Sarcoma	Mouse_Sarcoma|Non-Lymphoid_Hematopoietic_Neoplasm_of_Mouse	Mouse Non-lymphoid Hematopoietic Sarcoma|Non-lymphoid Hematopoietic Sarcoma	Bone marrow, if involved, contains at least focal areas in which hematopoiesis is preserved; Lesion is - invasive into surrounding tissues and/or - present at greater than 1 site; Primarily a solid tumor mass; Progression to a leukemic phase (blood involvement) can be observed.; The disease generally transplants as a solid tumor.
C21885	Mouse_Granulocytic_Hematopoietic_Sarcoma	Mouse_Non-lymphoid_Hematopoietic_Sarcoma	Mouse Granulocytic Sarcoma|Granulocytic Hematopoietic Sarcoma|Granulocytic Sarcoma|chloroma	Lesion is composed predominantly of granulocytic and/or relatively undifferentiated non-lymphoid hematopoietic cells
C21886	Mouse_Histiocytic_Hematopoietic_Sarcoma	Mouse_Non-lymphoid_Hematopoietic_Sarcoma	Mouse Histiocytic Sarcoma|Histiocytic Hematopoietic Sarcoma|Histiocytic Sarcoma|Kupffer cell lymphoma|Kupffer cell sarcoma|histiocytic lymphoma|malignant lymphoma, histiocytic type|reticulum cell sarcoma, type A	Lesion is composed predominantly of histiocytic cells
C21887	Mouse_Mast_Cell_Hematopoietic_Sarcoma	Mouse_Non-lymphoid_Hematopoietic_Sarcoma	Mouse Mast Cell Hematopoietic Sarcoma|Mast Cell Hematopoietic Sarcoma|Mast Cell Sarcoma|malignant mastocytoma; mast cell tumor, malignant	Cells exhibit features of mast cells; Lesion has characteristic cytology: uniform, closely packed cells with round nuclei and clear abundant cytoplasm with or without granules
C21888	Mouse_Non-lymphoid_Leukemia	Mouse_Leukemia|Non-Lymphoid_Hematopoietic_Neoplasm_of_Mouse	Mouse Non-lymphoid Leukemia|Non-lymphoid Leukemia	A non-lymphoid hematopoietic neoplasm that diffusely involves hematopoietic tissue, generally both the spleen and bone marrow; Comment: Additional descriptor may be applied if appropriate: Acute; Comment: Additional descriptor may be applied if appropriate: Therapy Related; Comment: Additional descriptor may be applied if appropriate: With Multilineage Dysplasia; Disorder exhibits additional aspect of malignancy in appearance or behavior; Mice exhibit anemia, neutropenia, and/or thrombocytopenia; Neoplastic cells are disseminated; Non-lymphoid hematopoietic cells are increased in spleen (generally in both bone marrow and spleen)
C21889	Mouse_Myeloid_Leukemia	Mouse_Myeloid_Cell_Neoplasm|Mouse_Non-lymphoid_Leukemia	Mouse Myeloid Leukemia|Myeloid Leukemia|granulocytic leukemia, myelogenous leukemia	Bone marrow cells are less than 50% erythroid cells; Bone marrow cells are less than 50% megakaryocytic cells; Comprised predominantly of granulocytic and/or monocytic cells and their precursors; NOT (greater than 90% immature forms/blasts in bone marrow AND bi-phenotypic)
C21890	Mouse_Myeloid_Leukemia_without_Maturation	Mouse_Myeloid_Leukemia	Mouse Myeloid Leukemia without Maturation|Myeloblastic leukemia without maturation|Myeloid Leukemia without Maturation|Myeloid leukemia without maturation	Comment: Leukemia in which neoplastic cells are poorly differentiated and not monocytic; Without a monocytic component; greater or equal to 20% immature forms/blasts in hematopoietic tissue (usually bone marrow, splenic non-lymphoid tissue can be used as an alternative); greater or equal to 90% of non-lymphoid, non-erythroid hematopoietic cells in hematopoietic tissue are immature forms/blasts
C21891	Mouse_Myeloid_Leukemia_with_Maturation	Mouse_Myeloid_Leukemia	Mouse Myeloid Leukemia with Maturation|Myeloblastic leukemia with maturation|Myeloid Leukemia with Maturation|Myeloid leukemia with maturation	Comment: Leukemia in which neoplastic cells are moderately differentiated and neutrophilic; With a neutrophilic component; Without a monocytic component; greater or equal to 20% immature forms/blasts in hematopoietic tissue; less than or equal to 90% of non-lymphoid, non-erythroid hematopoietic cells in hematopoietic tissue are immature forms/blasts
C21892	Mouse_MPD-like_Myeloid_Leukemia	Mouse_Myeloid_Leukemia	Mouse MPD-like Myeloid Leukemia|MPD-like Myeloid Leukemia	Comment: Leukemia in which neoplastic cells are well differentiated; less than 20% immature forms/blasts in hematopoietic tissue
C21893	Mouse_Myelomonocytic_Leukemia	Mouse_Myeloid_Leukemia	Mouse Myelomonocytic Leukemia|Myelomonocytic Leukemia	Comment: Leukemia in which neoplastic cells are moderately differentiated including both neutrophilic and monocytic cells; With a monocytic component; With a neutrophilic component; greater or equal to 20% immature forms/blasts in hematopoietic tissue
C21894	Mouse_Monocytic_Leukemia	Mouse_Monocyte_Neoplasm|Mouse_Myeloid_Leukemia	Mouse Monocytic Leukemia|Monocytic Leukemia	Comment: Leukemia in which neoplastic cells are poorly or moderately differentiated and monocytic; With a monocytic component; Without a neutrophilic component; greater or equal to 20% immature forms/blasts in hematopoietic tissue
C21895	Mouse_Erythroid_Leukemia	Mouse_Non-lymphoid_Leukemia	Mouse Erythroid Leukemia|Erythroid Leukemia|Erythroleukemia	greater than or equal to 50% nucleated erythroid cells in hematopoietic tissue
C21896	Mouse_Megakaryocytic_Leukemia	Mouse_Non-lymphoid_Leukemia	Mouse Megakaryocytic Leukemia|Megakaryocytic Leukemia	greater than or equal to 50% megakaryocytic cells in hematopoietic tissue
C21897	Mouse_Bi-phenotypic_Leukemia	Mouse_Non-lymphoid_Leukemia	Mouse Bi-phenotypic Leukemia|Bi-phenotypic Leukemia	Bi-phenotypic; greater or equal to 90% immature forms/blasts in hematopoietic tissue
C21898	Myeloid_Dysplasia_of_Mouse	Mouse_Hematologic_Disorder|Mouse_Precancerous_Conditions	Myeloid Dysplasia of Mouse|Myeloid Dysplasia	Comment: Intended to encompass diseases more closely related to human myelodysplastic syndromes than to human myelodysplastic/myeloproliferative or myeloproliferative diseases; Disorder is not a non-lymphoid leukemia; In the peripheral blood mice exhibit: A. Neutropenia (+/- anemia, +/- thrombocytopenia) or B. Thrombocytopenia without either leukocytosis or erythrocytosis or C. Anemia without either leukocytosis or thrombocytosis; Mice exhibit a defect in maturation of non-lymphoid hematopoietic cells as evidenced by any combination of: A. Dysgranulopoiesis, dyserythropoiesis, and/or dysplastic megakaryocytes or B.  greater or equal to 20% non-lymphoid immature forms/blasts in bone marrow and/or spleen
C21899	Mouse_Myelodysplastic_Syndrome	Myeloid_Dysplasia_of_Mouse	Mouse Myelodysplastic Syndrome|Myelodysplastic Syndrome	Comment: may be designated as having features of a named human MDS; Morphologic dysgranulopoiesis, dyserythropoiesis, and/or dysplastic megakaryocytes (with or without increased immature forms/blasts)
C21900	Cytopenia_with_Increased_Blasts_of_Mouse	Myeloid_Dysplasia_of_Mouse	Cytopenia with Increased Blasts of Mouse|Cytopenia with Increased Blasts	Without morphologic dysgranulopoiesis, dyserythropoiesis, or dysplastic megakaryocytes; greater or equal to 20% myeloid immature forms/blasts in bone marrow and/or spleen
C21901	Mouse_Myeloid_Proliferation	Mouse_Myeloid_Cell_Neoplasm|Non-Lymphoid_Hematopoietic_Neoplasm_of_Mouse	Mouse Myeloid Proliferation|Myeloid Proliferation|Myeloid Proliferation (non-reactive)	Comment: Intended to encompass diseases more closely related to human myelodysplastic/myeloproliferative or myeloproliferative diseases than to human myelodysplastic syndromes.  Myeloid proliferations (nonreactive) may be morphologically indistinguishable from reactive processes.  Reactive cause for increased numbers of nonlymphoid hematopoietic cells should be considered.  By definition, this diagnosis is for lesions that are nonreactive, persistent, and genetically determined.
C21902	Mouse_Myeloproliferation	Mouse_Myeloid_Proliferation	Mouse Myeloproliferation|Myeloproliferation|Myeloproliferation (genetic)	Comment: Intended to be used for disorders of genetically engineered mice that are not characterized by increased blood counts; Genetic
C21903	Mouse_Myeloproliferative_Disease	Mouse_Myeloid_Proliferation	Mouse Myeloproliferative Disease|Myeloproliferative Disease	A. Erythrocytosis, leukocytosis of myeloid cells, or thrombocytosis/circulating megakaryocytes AND B. Increased non-lymphoid hematopoietic cells in spleen and/or bone marrow; Comment: may be designated as having features of a named human MD/MPD or MPD
C21904	Lymphoid_Neoplasms_and_Related_Disorders_of_the_Mouse_Hematologic_System	Mouse_Hematologic_Neoplasms_and_Related_Disorders	Lymphoid Neoplasms and Related Disorders of the Mouse Hematologic System|Lymphoid Neoplasms and Related Disorders of the Hematologic System|Lymphoid neoplasms and related disorders
C21905	B_Cell_Neoplasms_of_the_Mouse_Hematologic_System	Lymphoid_Neoplasms_and_Related_Disorders_of_the_Mouse_Hematologic_System|Mouse_B_Cell_Neoplasms	B Cell Neoplasms of the Mouse Hematologic System|B Cell Neoplasms of the Hematologic System|B cell neoplasms
C21906	Precursor_B_Cell_Neoplasm_of_the_Mouse_Hematologic_System	B_Cell_Neoplasms_of_the_Mouse_Hematologic_System	Precursor B Cell Neoplasm of the Mouse Hematologic System|Precursor B Cell Neoplasm of the Hematologic System|Precursor B cell neoplasm
C21907	Mouse_Precursor_B_Cell_Lymphoblastic_Lymphoma_Leukemia	Precursor_B_Cell_Neoplasm_of_the_Mouse_Hematologic_System	Mouse Precursor B Cell Lymphoblastic Lymphoma and Leukemia|Lymphoblastic leukemia|Lymphoblastic lymphoma|Precursor B Cell Lymphoblastic Lymphoma/Leukemia|pre-B LBL	Frequent in some GEM and mice infected with acutely transforming MuLV; Necropsy findings: Splenomegaly, generalized lymphadenopathy, usually with extensive spread to liver, kidney, and lungs, sometimes to meninges with skull exostoses and hind limb paralysis; leukemic form in about one third of cases; Cell size: Medium, uniform; Cytoplasm: Scant; Nuclei: Round or ovoid; chromatin fine; Nucleoli: Variable, often single, central and prominent but sometimes small and multiple; Mitoses: Numerous; Pattern: Diffuse, sometimes starry sky because of apoptosis.
C21908	Mature_B_Cell_Neoplasms_of_the_Mouse_Hematologic_System	B_Cell_Neoplasms_of_the_Mouse_Hematologic_System	Mature B Cell Neoplasms of the Mouse Hematologic System|Mature B Cell Neoplasms of the Hematologic System|Mature B cell neoplasms
C21909	Small_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Mature_B_Cell_Neoplasms_of_the_Mouse_Hematologic_System	Small B Cell Lymphoma of the Mouse Hematologic System|SBL|Small B Cell Lymphoma of the Hematologic System|Small B cell lymphoma	Well differentiated mature sIg+, B220+ lymphocytes
C21910	Splenic_Marginal_Zone_Lymphoma_of_the_Mouse_Hematologic_System	Mature_B_Cell_Neoplasms_of_the_Mouse_Hematologic_System	Splenic Marginal Zone Lymphoma of the Mouse Hematologic System|SMZL|Splenic Marginal Zone Lymphoma of the Hematologic System|Splenic marginal zone lymphoma	Origin from splenic marginal zone, mature B cell
C21911	Follicular_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Mature_B_Cell_Neoplasms_of_the_Mouse_Hematologic_System	Follicular B Cell Lymphoma of the Mouse Hematologic System|FBL|Follicular B Cell Lymphoma of the Hematologic System|Follicular B cell lymphoma	Centroblastic/centriocytic, follicular center cell, from germinal center B cells
C21912	Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Mature_B_Cell_Neoplasms_of_the_Mouse_Hematologic_System	Diffuse Large B Cell Lymphoma of the Mouse Hematologic System|DLBCL|Diffuse Large B Cell Lymphoma of the Hematologic System|Diffuse large B cell lymphoma	Resembles human disease, was mouse follicular lymphoma, variants - centroblastic, immunoblastic, B220+.
C21913	Centroblastic_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Morphologic_Variants_of_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Centroblastic Diffuse Large B Cell Lymphoma of the Mouse Hematologic System|CB|Centroblastic|Centroblastic Diffuse Large B Cell Lymphoma of the Hematologic System	Mature B cell, sIg+
C21914	Immunoblastic_Diffuse_Large_B_Cell_LymphomaLymphoblastic_Lymphoma_Type_of_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Morphologic_Variants_of_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Immunoblastic Diffuse Large B Cell LymphomaLymphoblastic Lymphoma Type of Diffuse Large B Cell Lymphoma of the Mouse Hematologic System|IB|Immunoblastic|Immunoblastic Diffuse Large B Cell LymphomaLymphoblastic Lymphoma Type of Diffuse Large B Cell Lymphoma of the Hematologic System	Morphologic variant
C21915	Histiocyte-Associated_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Morphologic_Variants_of_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Histiocyte-Associated Diffuse Large B Cell Lymphoma of the Mouse Hematologic System|HA|Histiocyte-associated|Histiocyte-associated Diffuse Large B Cell Lymphoma of the Hematologic System|Histiocyte-associated Diffuse Large B Cell Lymphoma of the Mouse Hematologic System	Histiocyte-associated DLBCL, B220+, histiocytes F4/80+
C21916	Primary_Mediastinal_Thymic_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Subtypes_of_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Primary Mediastinal Thymic Diffuse Large B Cell Lymphoma of the Mouse Hematologic System|PM|Primary Mediastinal Thymic Diffuse Large B Cell Lymphoma of the Hematologic System|Primary mediastinal (thymic) diffuse large B cell lymphoma	Thymic B cell.
C21917	Classic_Burkitt_Lymphoma_of_the_Mouse_Hematologic_System	Mature_B_Cell_Neoplasms_of_the_Mouse_Hematologic_System	Classic Burkitt Lymphoma of the Mouse Hematologic System|BL|Burkitt-type lymphoma|Classic Burkitt Lymphoma of the Hematologic System	Mature B cell, lymphoblastic, starry sky effect
C21918	Plasma_Cell_Neoplasm_of_the_Mouse_Hematologic_System	Mature_B_Cell_Neoplasms_of_the_Mouse_Hematologic_System	Plasma Cell Neoplasm of the Mouse Hematologic System|Plasma Cell Neoplasm of the Hematologic System|Plasma cell lymphoma
C21919	Plasmacytoma_of_the_Mouse_Hematologic_System	Plasma_Cell_Neoplasm_of_the_Mouse_Hematologic_System	Plasmacytoma of the Mouse Hematologic System|PCT|Plasmacytoma|Plasmacytoma of the Hematologic System	Plasma cell lymphoma, secretory B cell.
C21920	Extraosseus_Plasmacytoma_of_the_Mouse_Hematologic_System	Plasma_Cell_Neoplasm_of_the_Mouse_Hematologic_System	Extraosseus Plasmacytoma of the Mouse Hematologic System|Extraosseus Plasmacytoma of the Hematologic System|PCT-E	Non-bone marrow plasmacytoma. Secretory B cell
C21921	Anaplastic_Plasmacytoma_of_the_Mouse_Hematologic_System	Plasma_Cell_Neoplasm_of_the_Mouse_Hematologic_System	Anaplastic Plasmacytoma of the Mouse Hematologic System|Anaplastic Plasmacytoma of the Hematologic System|Anaplastic plasmacytoma|PCT-A	Immunoblastic/plasmablastic.
C21922	B-NK_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Mature_B_Cell_Neoplasms_of_the_Mouse_Hematologic_System	B-NK Cell Lymphoma of the Mouse Hematologic System|B-NK Cell Lymphoma of the Hematologic System|BNKL|NK-B cell lymphoma	Rare, Thymectomized line of mice only, B220+, CD5+.
C21923	T_Cell_Neoplasms_of_the_Mouse_Hematologic_System	Lymphoid_Neoplasms_and_Related_Disorders_of_the_Mouse_Hematologic_System|Mouse_T_Cell_Neoplasms	T Cell Neoplasms of the Mouse Hematologic System|T Cell Neoplasms of the Hematologic System|T cell neoplasms
C21924	Precursor_T_Cell_Neoplasm_of_the_Mouse_Hematologic_System	T_Cell_Neoplasms_of_the_Mouse_Hematologic_System	Precursor T Cell Neoplasm of the Mouse Hematologic System|Precursor T Cell Neoplasm of the Hematologic System|Precursor T cell neoplasm
C21925	Mouse_Precursor_T_Cell_Lymphoblastic_Lymphoma_Leukemia	Precursor_T_Cell_Neoplasm_of_the_Mouse_Hematologic_System	Mouse Precursor T Cell Lymphoblastic Lymphoma/Leukemia|Precursor T Cell Lymphoblastic Lymphoma/Leukemia|Precursor T cell lymphoblastic lymphoma/leukemia|pre-T LBL	Lymphoblastic, CD3+, cytTdT+, usually thymic origin
C21926	Large_Cell_Anaplastic_Lymphoma_of_the_Mouse_Hematologic_System	T_Cell_Neoplasms_of_Undetermined_Character_of_the_Mouse_Hematologic_System	Large Cell Anaplastic Lymphoma of the Mouse Hematologic System|Large Cell Anaplastic Lymphoma of the Hematologic System|Large cell anaplastic lymphoma|TCLA	High grade, anaplastic, thymic.
C21927	Mature_T_Cell_Lineage_Lymphoma_of_the_Mouse_Hematologic_System	T_Cell_Neoplasms_of_the_Mouse_Hematologic_System	Mature T Cell Lineage Lymphoma of the Mouse Hematologic System|Mature T Cell Lineage Lymphoma of the Hematologic System|Mature T cell lineage lymphoma
C21928	Small_T_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Mature_T_Cell_Lineage_Lymphoma_of_the_Mouse_Hematologic_System	Small T Cell Lymphoma of the Mouse Hematologic System|STL|Small T Cell Lymphoma of the Hematologic System|Small T cell lymphoma	Lymphocytic, peripheral T cell, CD3+.
C21929	Mouse_T-NK_Cell_Lymphoma	Mature_T_Cell_Lineage_Lymphoma_of_the_Mouse_Hematologic_System	Mouse T-NK Cell Lymphoma|NK-T cell lymphoma/leukemia|T-NK Cell Lymphoma|TNKL	IL-15 transgenic mouse, CD3+, resembles LGL leukemia.
C21930	Mouse_Nervous_System_Neoplasms	Mouse_Neoplasms_by_Location|Mouse_Nervous_System_Disorder	Mouse Nervous System Neoplasms|Mouse Nervous System Disorders|Nervous System Neoplasms
C21931	Mouse_Tumors_of_Neuroepithelial_Tissue	Mouse_Nervous_System_Neoplasms	Mouse Tumors of Neuroepithelial Tissue|GENETICALLY ENGINEERED MURINE (GEM) TUMOURS OF NEUROEPITHELIAL TISSUE|Tumors of Neuroepithelial Tissue
C21932	Mouse_Astrocytic_Tumours	Mouse_Neuroglia_Neoplasm|Mouse_Tumors_of_Neuroepithelial_Tissue	Mouse Astrocytic Tumours|Astrocytic Tumours|GEM Astrocytic tumours
C21933	Mouse_Diffuse_Astrocytoma	Mouse_Astrocytic_Tumours	Mouse Diffuse Astrocytoma|Diffuse Astrocytoma|GEM Diffuse astrocytoma|diffuse astrocytic neoplasm	Low-grade glial neoplasm characterized by fibrillary or gemistocytic astrocytic differentiation, slow growth, and diffuse infiltration of neighboring brain structures. Low to inapparent mitotic activity, and the absence of vascular proliferation and tumor necrosis differentiate this neoplasm from the higher grade lesions: anaplastic astrocytoma, and glioblastoma.  Normal and neoplastic astrocytes express GFAP (glial fibrillary acid protein).
C21934	Mouse_Fibrillary_Astrocytoma	Mouse_Diffuse_Astrocytoma	Mouse Fibrillary Astrocytoma|Fibrillary Astrocytoma|GEM Fibrillary astrocytoma|fibrillary astrocytic neoplasm; fibrous astrocytic neoplasm; fibrous astrocytoma	Common subtype of Diffuse Astrocytoma, predominantly composed of fibrillary neoplastic astrocytes.
C21935	Mouse_Protoplasmic_Astrocytoma	Mouse_Diffuse_Astrocytoma	Mouse Protoplasmic Astrocytoma|GEM Protoplasmic astrocytoma|Protoplasmic Astrocytoma|protoplasmic astrocytic neoplasm	Variant of Diffuse Astrocytoma, predominantly composed of neoplastic astrocytes showing a small cell body with few, flaccid processes with a low content of glial filaments and scant GFAP expression.
C21936	Mouse_Gemistocytic_Astrocytoma	Mouse_Diffuse_Astrocytoma	Mouse Gemistocytic Astrocytoma|GEM Gemistocytic astrocytoma|Gemistocytic Astrocytoma|gemistocytic astrocytic neoplasm; gemistocytoma	Variant of Diffuse Astrocytoma characterized by the presence of a conspicuous, though variable, fraction of "Gemistocytes" --round to oval astrocytes with abundant, glassy, non-fibrillary cytoplasm which appears to displace the dark, angulated nucleus to the periphery of the cell. To make the diagnosis of Gemistocytic Astrocytoma, gemistocytes should amount to more than approximately 20% of all tumor cells (fewer is considered a fibrillary astrocytoma).  Gemistocytes are strongly GFAP positive.
C21937	Mouse_Anaplastic_Astrocytoma	Mouse_Astrocytic_Tumours	Mouse Anaplastic Astrocytoma|Anaplastic Astrocytoma|GEM Anaplastic astrocytoma|anaplastic astrocytic neoplasm; grade iii astrocytic neoplasm; malignant astrocytic neoplasm; undifferentiated astrocytic neoplasm; grade iii astrocytoma; malignant astrocytoma; undifferentiated astrocytoma	Intermediate grade glial neoplasm characterized by increased cellularity, nuclear pleomorphism, mitoses, and variable vascular endothelial proliferation without tumor necrosis.
C21938	Mouse_Glioblastoma	Mouse_Astrocytic_Tumours	Mouse Glioblastoma|GEM Glioblastoma|Glioblastoma	A high grade glial neoplasm consisting chiefly of undifferentiated anaplastic cells of glial origin that show marked nuclear pleomorphism.  The diagnosis also depends on findings of tumor necrosis, and vascular endothelial proliferation. Frequently, tumor cells are arranged radially about an irregular focus of necrosis. These neoplasms grow rapidly, invade extensively and aggressively.
C21939	Mouse_Giant_Cell_Glioblastoma	Mouse_Glioblastoma	Mouse Giant Cell Glioblastoma|GEM Giant cell glioblastoma|Giant Cell Glioblastoma	Giant Cell Glioblastoma is a histological variant of Glioblastoma with a predominance of bizarre, multinucleated giant cells, an occasionally abundant stromal reticulin network and a high frequency of TP53 mutations.
C21940	Mouse_Gliosarcoma	Mouse_Glioblastoma	Mouse Gliosarcoma|GEM Gliosarcoma|Gliosarcoma|glioblastoma with a sarcomatous component; feigin tumor	histological variant of Glioblastoma and characterized by a biphasic tissue pattern with alternating areas displaying glial and mesenchymal differentiation
C21941	Mouse_Pilocytic_Astrocytoma	Mouse_Astrocytic_Tumours	Mouse Pilocytic Astrocytoma|GEM Pilocytic astrocytoma|Pilocytic Astrocytoma|piloid astrocytic neoplasm; piloid astrocytoma	Low grade astrocytic tumor. It is a generally well circumscribed, slowly growing, often cystic, astrocytoma. It is histologically characterized by a biphasic pattern with varying proportion of compacted bipolar cells which may have Rosenthal fibers (tapered corkscrew-shaped, brightly eosinophilic, intracytoplasmic hyaline masses) and loose textured multipolar cells with microcysts and granular bodies.
C21942	Mouse_Pleomorphic_Xanthoastrocytoma	Mouse_Astrocytic_Tumours	Mouse Pleomorphic Xanthoastrocytoma|GEM Pleomorphic xanthoastrocytoma|Pleomorphic Xanthoastrocytoma
C21943	Mouse_Subependymal_Giant_Cell_Astrocytoma	Mouse_Astrocytic_Tumours	Mouse Subependymal Giant Cell Astrocytoma|GEM Subependymal giant cell astrocytoma|Subependymal Giant Cell Astrocytoma|subependymal giant cell astrocytic neoplasm; giant cell subependymoma
C21944	Mouse_Oligodendroglial_Tumours	Mouse_Neuroglia_Neoplasm|Mouse_Tumors_of_Neuroepithelial_Tissue	Mouse Oligodendroglial Tumours|GEM Oligodendroglial tumours|Oligodendroglial Tumours
C21945	Mouse_Oligodendroglioma	Mouse_Oligodendroglial_Tumours	Mouse Oligodendroglioma|GEM Oligodendroglioma|Oligodendroglioma|oligodendroglial neoplasm	Glial neoplasm composed of oligodendrocytes.  This neoplasm is characterized by uniform cell density and nuclear size and shape, often with round nuclei surrounded by a halo of clear cytoplasm.  These cells are typically highly infiltrative.  Calcification is a hallmark of the human oligodendroglioma, and may be expected in mouse as well.
C21946	Mouse_Anaplastic_Oligodendroglioma	Mouse_Oligodendroglial_Tumours	Mouse Anaplastic Oligodendroglioma|Anaplastic Oligodendroglioma|GEM Anaplastic oligodendroglioma|malignant oligodendroglioma; undifferentiated oligodendroglioma	Oligodendroglioma with greater cellularity, cytologic atypia, and mitotic activity.  Similar to astrocytic glial tumors, these higher grade lesions show increased vascularity and tumor necrosis.
C21947	Mixed_Mouse_Gliomas	Mouse_Neuroglia_Neoplasm|Mouse_Tumors_of_Neuroepithelial_Tissue	Mixed Mouse Gliomas|GEM Mixed gliomas|Mixed Gliomas|mixed glial neoplasm
C21948	Mouse_Oligoastrocytoma	Mixed_Mouse_Gliomas	Mouse Oligoastrocytoma|GEM Oligoastrocytoma|Oligoastrocytoma	A glial neoplasm showing two distinct cell populations one with astrocytic and one with oligodendrocytic differentiation.
C21949	Mouse_Anaplastic_Oligoastrocytoma	Mixed_Mouse_Gliomas	Mouse Anaplastic Oligoastrocytoma|Anaplastic Oligoastrocytoma|GEM Anaplastic oligoastrocytoma	An oligoastrocytoma increased cellularity, cytologic atypia, and increased mitotic activity.  Often there is also an increased vascularity and tumor necrosis.
C21950	Mouse_Ependymal_Tumours	Mouse_Tumors_of_Neuroepithelial_Tissue	Mouse Ependymal Tumours|Ependymal Tumours|GEM Ependymal tumours
C21951	Mouse_Ependymoma	Mouse_Ependymal_Tumours	Mouse Ependymoma|Ependymoma|GEM Ependymoma	Neoplasm of ependymal cells (cells lining the cerebral ventricles and spinal canal.  Typically they are well circumscribed, growing with a pushing border.  Histologically they are characterized by perivascular pseudo-rosettes.
C21952	Mouse_Cellular_Ependymoma	Mouse_Ependymoma	Mouse Cellular Ependymoma|Cellular Ependymoma|GEM Cellular ependymoma
C21953	Mouse_Papillary_Ependymoma	Mouse_Ependymoma	Mouse Papillary Ependymoma|GEM Papillary ependymoma|Papillary Ependymoma	Variant of Ependymoma characterized by well formed papillae. Tumor cell processes abutting capillaries are usually GFAP-positive.
C21954	Mouse_Clear_Cell_Ependymoma	Mouse_Ependymoma	Mouse Clear Cell Ependymoma|Clear Cell Ependymoma|GEM Clear cell ependymoma
C21955	Mouse_Tanycytic_Ependymoma	Mouse_Ependymoma	Mouse Tanycytic Ependymoma|GEM Tanycytic ependymoma|Tanycytic Ependymoma
C21956	Mouse_Anaplastic_Ependymoma	Mouse_Ependymal_Tumours	Mouse Anaplastic Ependymoma|Anaplastic Ependymoma|GEM Anaplastic ependymoma|anaplastic ependymal neoplasm; undifferentiated ependymal neoplasm; undifferentiated ependymoma
C21957	Mouse_Myxopapillary_Ependymoma	Mouse_Ependymal_Tumours	Mouse Myxopapillary Ependymoma|GEM Myxopapillary ependymoma|Myxopapillary Ependymoma
C21958	Mouse_Subependymoma	Mouse_Ependymal_Tumours	Mouse Subependymoma|GEM Subependymoma|Subependymoma|subependymal astrocytoma; subependymal glioma
C21959	Mouse_Choroid_Plexus_Tumours	Mouse_Tumors_of_Neuroepithelial_Tissue	Mouse Choroid Plexus Tumours|Choroid Plexus Tumours|GEM Choroid plexus tumours	Neoplasm of the choroid plexus cells (CSF producing cells) of the third ventricle.  Choroid plexus cells co-express cytokeratins, vimentin, and S-100.
C21960	Mouse_Choroid_Plexus_Papilloma	Mouse_Choroid_Plexus_Tumours|Mouse_Papilloma	Mouse Choroid Plexus Papilloma|Choroid Plexus Papilloma|GEM Choroid plexus papilloma	A non-invasive Choroid Plexus Tumor with a papillary architecture.
C21961	Mouse_Choroid_Plexus_Carcinoma	Mouse_Carcinoma|Mouse_Choroid_Plexus_Tumours	Mouse Choroid Plexus Carcinoma|Choroid Plexus Carcinoma|GEM Choroid plexus carcinoma	An infiltrating Choroid Plexus Tumor with nuclear pleomorphism, increased mitoses, and often tumor necrosis.
C21962	Mouse_Glial_Tumours_of_Uncertain_Origin	Mouse_Neuroglia_Neoplasm|Mouse_Tumors_of_Neuroepithelial_Tissue	Mouse Glial Tumours of Uncertain Origin|GEM Glial tumours of uncertain origin|Glial Tumours of Uncertain Origin
C21963	Mouse_Astroblastoma	Mouse_Glial_Tumours_of_Uncertain_Origin	Mouse Astroblastoma|Astroblastoma|GEM Astroblastoma
C21964	Mouse_Gliomatosis_Cerebri	Mouse_Glial_Tumours_of_Uncertain_Origin	Mouse Gliomatosis Cerebri|GEM Gliomatosis cerebri|Gliomatosis Cerebri
C21965	Mouse_Chordoid_Glioma_of_the_3rd_Ventricle	Mouse_Glial_Tumours_of_Uncertain_Origin	Mouse Chordoid Glioma of the 3rd Ventricle|Chordoid Glioma of the 3rd Ventricle|GEM Chordoid glioma of the 3rd ventricle|third ventricle chordoid glioma
C21966	Mouse_Neuronal_and_Mixed_Neuronal-glial_Tumours	Mouse_Neural_Cell_Neoplasm|Mouse_Neuroglia_Neoplasm|Mouse_Tumors_of_Neuroepithelial_Tissue	Mouse Neuronal and Mixed Neuronal-glial Tumours|GEM Neuronal and mixed neuronal-glial tumours|Neuronal and Mixed Neuronal-glial Tumours
C21967	Mouse_Gangliocytoma	Mouse_Neuronal_and_Mixed_Neuronal-glial_Tumours	Mouse Gangliocytoma|GEM Gangliocytoma|Gangliocytoma
C21968	Dysplastic_Lhermitte-Duclos_Gangliocytoma_of_Mouse_Cerebellum	Mouse_Neuronal_and_Mixed_Neuronal-glial_Tumours	Dysplastic Lhermitte-Duclos Gangliocytoma of Mouse Cerebellum|Astrocytoma Grade IV|Dysplastic Lhermitte-Duclos Gangliocytoma of Cerebellum|GEM Dysplastic gangliocytoma of cerebellum (Lhermitte-Duclos)|dysplastic cerebellar gangliocytoma; dysplastic gangliocytoma of the cerebellum; Lhermitte-Duclos disease
C21969	Mouse_Desmoplastic_Infantile_Astrocytoma_Ganglioglioma	Mouse_Neuronal_and_Mixed_Neuronal-glial_Tumours	Mouse Desmoplastic Infantile Astrocytoma / Ganglioglioma|Desmoplastic Infantile Astrocytoma / Ganglioglioma|Desmoplastic infantile astrocytoma; desmoplastic infantile astrocytic neoplasm; desmoplastic infantile ganglioglioma; desmoplastic infantile neuroastrocytoma|GEM Desmoplastic infantile astrocytoma / ganglioglioma
C21970	Mouse_Dysembryoplastic_Neuroepithelial_Tumour	Mouse_Neuronal_and_Mixed_Neuronal-glial_Tumours	Mouse Dysembryoplastic Neuroepithelial Tumour|Dysembryoplastic Neuroepithelial Tumour|GEM Dysembryoplastic neuroepithelial tumour|dysembryoplastic neuroepithelial neoplasm; DNET
C21971	Mouse_Ganglioglioma	Mouse_Neuronal_and_Mixed_Neuronal-glial_Tumours	Mouse Ganglioglioma|GEM Ganglioglioma|Ganglioglioma|neuroastrocytoma
C21972	Mouse_Anaplastic_Ganglioglioma	Mouse_Neuronal_and_Mixed_Neuronal-glial_Tumours	Mouse Anaplastic Ganglioglioma|Anaplastic Ganglioglioma|GEM Anaplastic ganglioglioma|anaplastic neuroastrocytoma
C21973	Mouse_Central_Neurocytoma	Mouse_Neuronal_and_Mixed_Neuronal-glial_Tumours	Mouse Central Neurocytoma|Central Neurocytoma|GEM Central neurocytoma|central nervous system neurocytoma; cns neurocytoma
C21974	Mouse_Cerebellar_Liponeurocytoma	Mouse_Neuronal_and_Mixed_Neuronal-glial_Tumours	Mouse Cerebellar Liponeurocytoma|Cerebellar Liponeurocytoma|GEM Cerebellar liponeurocytoma
C21975	Paraganglioma_of_the_Mouse_Filum_Terminale	Mouse_Neuronal_and_Mixed_Neuronal-glial_Tumours	Paraganglioma of the Mouse Filum Terminale|GEM Paraganglioma of the filum terminale|Paraganglioma of the Filum Terminale
C21976	Mouse_Neuroblastic_Tumours	Mouse_Neuroglia_Neoplasm|Mouse_Tumors_of_Neuroepithelial_Tissue	Mouse Neuroblastic Tumours|GEM Neuroblastic tumours|Neuroblastic Tumours
C21977	Mouse_Olfactory_Neuroblastoma	Mouse_Neuroblastic_Tumours	Mouse Olfactory Neuroblastoma|Aesthesioneuroblastoma|GEM Olfactory neuroblastoma (Aesthesioneuroblastoma )|Olfactory Neuroblastoma|esthesioneuroblastoma; olfactory esthesioneuroblastoma; olfactory neural neoplasm; olfactory neuroblastoma
C21978	Mouse_Olfactory_Neuroepithelioma	Mouse_Neuroblastic_Tumours	Mouse Olfactory Neuroepithelioma|GEM Olfactory neuroepithelioma|Olfactory Neuroepithelioma|olfactory primitive neuroectodermal neoplasm; olfactory pnet
C21979	Neuroblastomas_of_the_Mouse_Adrenal_Gland_and_Sympathetic_Nervous_System	Mouse_Neuroblastic_Tumours	Neuroblastomas of the Mouse Adrenal Gland and Sympathetic Nervous System|GEM Neuroblastomas of the adrenal gland and sympathetic nervous system|Neuroblastomas of the Adrenal Gland and Sympathetic Nervous System
C21980	Mouse_Pineal_Parenchymal_Tumours	Mouse_Tumors_of_Neuroepithelial_Tissue	Mouse Pineal Parenchymal Tumours|GEM Pineal parenchymal tumours|Pineal Parenchymal Tumours
C21981	Mouse_Pineocytoma	Mouse_Pineal_Parenchymal_Tumours	Mouse Pineocytoma|GEM Pineocytoma|Pineocytoma|pinealoma
C21982	Mouse_Pineoblastoma	Mouse_Pineal_Parenchymal_Tumours	Mouse Pineoblastoma|GEM Pineoblastoma|Pineoblastoma|pineal gland primitive neuroectodermal neoplasm; pineal gland pnet; pineal primitive neuroectodermal neoplasm; pineal pnet	Invasive embryonal neoplasm of the pineal gland showing neuronal differentiation histologically (Homer-Wright and/or Flexner-Wintersteiner rosette formation) by immunohistochemistry (synaptophysin, chromogranin, or NSE expression), or by electron microscopy (dense core vesicles and microtubules).
C21983	Mouse_Pineal_Parenchymal_Tumour_of_Intermediate_Differentiation	Mouse_Pineal_Parenchymal_Tumours	Mouse Pineal Parenchymal Tumour of Intermediate Differentiation|GEM Pineal parenchymal tumour of intermediate differentiation|Pineal Parenchymal Tumour of Intermediate Differentiation
C21984	Mouse_Embryonal_Tumours	Mouse_Tumors_of_Neuroepithelial_Tissue	Mouse Embryonal Tumours|Embryonal Tumours|GEM Embryonal tumours
C21985	Mouse_Medulloepithelioma	Mouse_Embryonal_Tumours	Mouse Medulloepithelioma|GEM Medulloepithelioma|Medulloepithelioma
C21986	Mouse_Ependymoblastoma	Mouse_Embryonal_Tumours	Mouse Ependymoblastoma|Ependymoblastoma|GEM Ependymoblastoma|PNET with ependymal differentiation
C21987	Mouse_Medulloblastoma	Mouse_Embryonal_Tumours	Mouse Medulloblastoma|GEM Medulloblastoma|Medulloblastoma|cerebellar small cell neuroectodermal neoplasm; small cell neuroectodermal neoplasm of the cerebellum; cerebellar medulloblastoma; medulloblastoma of the cerebellum	Invasive embryonal neoplasm of the cerebellum showing neuronal differentiation histologically (Homer-Wright and/or Flexner-Wintersteiner rosette formation) by immunohistochemistry (synaptophysin, chromogranin, or NSE expression), or by electron microscopy (dense core vesicles and microtubules).
C21988	Mouse_Desmoplastic_Medulloblastoma	Mouse_Medulloblastoma	Mouse Desmoplastic Medulloblastoma|Desmoplastic Medulloblastoma|GEM Desmoplastic medulloblastoma
C21989	Mouse_Large_Cell_Medulloblastoma	Mouse_Medulloblastoma	Mouse Large Cell Medulloblastoma|GEM Large cell medulloblastoma|Large Cell Medulloblastoma
C21990	Mouse_Medullomyoblastoma	Mouse_Medulloblastoma	Mouse Medullomyoblastoma|GEM Medullomyoblastoma|Medullomyoblastoma
C21991	Mouse_Melanotic_Medulloblastoma	Mouse_Medulloblastoma	Mouse Melanotic Medulloblastoma|GEM Melanotic medulloblastoma|Melanotic Medulloblastoma|melanotic cerebellar small cell neuroectodermal neoplasm; melanotic small cell neuroectodermal neoplasm of the cerebellum
C21992	Mouse_Supratentorial_Primitive_Neuroectodermal_Tumour	Mouse_Embryonal_Tumours	Mouse Supratentorial Primitive Neuroectodermal Tumour|GEM Supratentorial primitive neuroectodermal tumour (PNET)|PNET|Supratentorial Primitive Neuroectodermal Tumour
C21993	Mouse_Neuroblastoma	Mouse_Supratentorial_Primitive_Neuroectodermal_Tumour	Mouse Neuroblastoma|GEM Neuroblastoma|Neuroblastoma
C21994	Mouse_Ganglioneuroblastoma	Mouse_Supratentorial_Primitive_Neuroectodermal_Tumour	Mouse Ganglioneuroblastoma|GEM Ganglioneuroblastoma|Ganglioneuroblastoma
C21995	Atypical_Mouse_Tertoid_Thaboid_Tumour	Mouse_Embryonal_Tumours	Atypical Mouse Tertoid/Thaboid Tumour|Astrocytoma Grade II|Atypical Tertoid/Thaboid Tumour|GEM Atypical teratoid/rhabdoid tumour
C21996	Tumors_of_the_Mouse_Peripheral_Nerves	Mouse_Nervous_System_Neoplasms	Tumors of the Mouse Peripheral Nerves|GEM TUMOURS OF PERIPHERAL NERVES|Tumors of the Peripheral Nerves
C21997	Mouse_Schwannoma	Mouse_Neuroglia_Neoplasm|Tumors_of_the_Mouse_Peripheral_Nerves	Mouse Schwannoma|GEM Schwannoma|Neurilemmoma; Neurinoma|Schwannoma
C21998	Mouse_Cellular_Neurilemmoma_Neurinoma	Atypical_Mouse_Tertoid_Thaboid_Tumour	Mouse Cellular Neurilemmoma / Neurinoma|Cellular Neurilemmoma / Neurinoma|GEM Cellular Neurilemmoma, Neurinoma|cellular schwannoma
C21999	Mouse_Plexiform_Neurilemmoma_Neurinoma	Atypical_Mouse_Tertoid_Thaboid_Tumour	Mouse Plexiform Neurilemmoma / Neurinoma|GEM Plexiform Neurilemmoma, Neurinoma|Plexiform Neurilemmoma / Neurinoma|plexiform schwannoma
C22000	Mouse_Melanotic_Neurilemmoma_Neurinoma	Atypical_Mouse_Tertoid_Thaboid_Tumour	Mouse Melanotic Neurilemmoma / Neurinoma|GEM Melanotic Neurilemmoma, Neurinoma|Melanotic Neurilemmoma / Neurinoma|melanocytic schwannoma; melanocytic neurilemmoma; melanotic schwannoma; pigmented neurilemmoma; pigmented schwannoma
C22001	Mouse_Neurofibroma	Mouse_Fibroma|Mouse_Neural_Cell_Neoplasm|Tumors_of_the_Mouse_Peripheral_Nerves	Mouse Neurofibroma|GEM Neurofibroma|Neurofibroma	Peripheral nervous system tumor composed of a mixture of cell types including Schwann cells, perineural cells, and fibroblasts.  Focal cells with S100 expression define the Schwann cells.
C22002	Mouse_Plexiform_Neurofibroma	Mouse_Neurofibroma	Mouse Plexiform Neurofibroma|GEM Plexiform neurofibroma|Plexiform Neurofibroma
C22003	Mouse_Perineurioma	Mouse_Neuroglia_Neoplasm|Tumors_of_the_Mouse_Peripheral_Nerves	Mouse Perineurioma|GEM Perineurioma|Perineurioma
C22004	Mouse_Intraneural_Perineurioma	Mouse_Perineurioma	Mouse Intraneural Perineurioma|GEM Intraneural perineurioma|Intraneural Perineurioma
C22005	Mouse_Soft_Tissue_Perineurioma	Mouse_Perineurioma	Mouse Soft Tissue Perineurioma|GEM Soft tissue perineurioma|Soft Tissue Perineurioma
C22006	Malignant_Mouse_Peripheral_Nerve_Sheath_Tumor	Mouse_Neural_Cell_Neoplasm|Tumors_of_the_Mouse_Peripheral_Nerves	Malignant Mouse Peripheral Nerve Sheath Tumor|GEM Malignant peripheral nerve sheath tumour (MPNST)|Malignant Peripheral Nerve Sheath Tumor|neurofibrosarcoma; malignant neoplasm of the peripheral nerve sheath; malignant peripheral nerve sheath tumor; malignant schwannoma; MPNST; neurilemmosarcoma; epithelioid neurofibrosarcoma; neurogenic sarcoma
C22007	Mouse_Epithelioid_MPNST	Malignant_Mouse_Peripheral_Nerve_Sheath_Tumor	Mouse Epithelioid MPNST|Epithelioid MPNST|GEM Epithelioid MPNST|malignant epithelioid schwannoma; malignant epithelioid neoplasm of the peripheral nerve sheath; malignant epithelioid neurilemmoma; epithelioid neurofibrosarcoma; epithelioid neurogenic sarcoma
C22008	Mouse_MPNST_with_Divergent_Mesenchymal_and_or_Epithelial_Differentiation	Malignant_Mouse_Peripheral_Nerve_Sheath_Tumor	Mouse MPNST with Divergent Mesenchymal and / or Epithelial Differentiation|GEM MPNST with divergent mesenchymal and / or epithelial differentiation|MPNST with Divergent Mesenchymal and / or Epithelial Differentiation
C22009	Mouse_Melanotic_MPNST	Malignant_Mouse_Peripheral_Nerve_Sheath_Tumor	Mouse Melanotic MPNST|GEM Melanotic MPNST|Melanotic MPNST
C22010	Mouse_Melanotic_Psammomatous_MPNST	Malignant_Mouse_Peripheral_Nerve_Sheath_Tumor	Mouse Melanotic Psammomatous MPNST|GEM Melanotic psammomatous MPNST|Melanotic Psammomatous MPNST
C22011	Tumors_of_the_Mouse_Meninges	Mouse_Nervous_System_Neoplasms	Tumors of the Mouse Meninges|GEM TUMOURS OF THE MENINGES|Tumors of the Meninges
C22012	Tumors_of_the_Mouse_Meningothelial_Cells	Tumors_of_the_Mouse_Meninges	Tumors of the Mouse Meningothelial Cells|GEM Tumours of meningothelial cells|Tumors of the Meningothelial Cells
C22013	Mouse_Meningioma	Tumors_of_the_Mouse_Meningothelial_Cells	Mouse Meningioma|GEM Meningioma|Meningioma	Neoplasms of the meningeal coverings, typically well demarcated with pushing encapsulated borders.  A wide range of architectures are possible, but psammoma body formation is classical.  Subtypes describe other variant architectures.
C22014	Mouse_Meningothelial_Meningioma	Mouse_Meningioma	Mouse Meningothelial Meningioma|GEM Meningothelial meningioma|Meningothelial Meningioma
C22015	Mouse_Fibrous_Fibroblastic_Meningioma	Mouse_Meningioma	Mouse Fibrous / Fibroblastic Meningioma|Fibrous / Fibroblastic Meningioma|GEM Fibrous (fibroblastic) meningioma|fibroblastic meningioma; fibrous meningioma
C22016	Mouse_Transitional_Mixed_Meningioma	Mouse_Meningioma	Mouse Transitional Mixed Meningioma|GEM Transitional (mixed) meningioma|Transitional Mixed Meningioma|Transitional meningioma; mixed meningioma
C22017	Mouse_Psammomatous_Meningioma	Mouse_Meningioma	Mouse Psammomatous Meningioma|GEM Psammomatous meningioma|Psammomatous Meningioma
C22018	Mouse_Angiomatous_Meningioma	Mouse_Meningioma	Mouse Angiomatous Meningioma|Angiomatous Meningioma|GEM Angiomatous meningioma
C22019	Mouse_Microcystic_Meningioma	Mouse_Meningioma	Mouse Microcystic Meningioma|GEM Microcystic meningioma|Microcystic Meningioma
C22020	Mouse_Secretory_Meningioma	Mouse_Meningioma	Mouse Secretory Meningioma|GEM Secretory meningioma|Secretory Meningioma
C22021	Mouse_Lymphoplasmacyte-rich_Meningioma	Mouse_Meningioma	Mouse Lymphoplasmacyte-rich Meningioma|GEM Lymphoplasmacyte-rich meningioma|Lymphoplasmacyte-rich Meningioma
C22022	Mouse_Metaplastic_Meningioma	Mouse_Meningioma	Mouse Metaplastic Meningioma|GEM Metaplastic meningioma|Metaplastic Meningioma
C22023	Mouse_Clear_Cell_Meningioma	Mouse_Meningioma	Mouse Clear Cell Meningioma|Clear Cell Meningioma|GEM Clear cell meningioma
C22024	Mouse_Chordoid_Meningioma	Mouse_Meningioma	Mouse Chordoid Meningioma|Chordoid Meningioma|GEM Chordoid meningioma
C22025	Atypical_Mouse_Meningioma	Mouse_Meningioma	Atypical Mouse Meningioma|Astrocytoma Grade II|Atypical Meningioma|GEM Atypical meningioma
C22026	Mouse_Papillary_Meningioma	Mouse_Meningioma	Mouse Papillary Meningioma|GEM Papillary meningioma|Papillary Meningioma
C22027	Mouse_Rhabdoid_Meningioma	Mouse_Meningioma	Mouse Rhabdoid Meningioma|GEM Rhabdoid meningioma|Rhabdoid Meningioma
C22028	Mouse_Anaplastic_Meningioma	Mouse_Meningioma	Mouse Anaplastic Meningioma|Anaplastic Meningioma|GEM Anaplastic meningioma
C22029	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System	Tumors_of_the_Mouse_Meninges	Mesenchymal Non-meningothelial Tumours of the Mouse Nervous System|GEM Mesenchymal, non-meningothelial tumours|Mesenchymal Non-meningothelial Tumours of the Nervous System
C22030	Lipoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System|Mouse_Lipoma	Lipoma of the Mouse Nervous System|GEM Lipoma|Lipoma of the Nervous System
C22031	Angiolipoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System	Angiolipoma of the Mouse Nervous System|Angiolipoma of the Nervous System|Astrocytoma Grade I|GEM Angiolipoma
C22032	Hibernoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System	Hibernoma of the Mouse Nervous System|GEM Hibernoma|Hibernoma of the Nervous System
C22033	Intracranial_Liposarcoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System	Intracranial Liposarcoma of the Mouse Nervous System|GEM Liposarcoma (intracranial)|Intracranial Liposarcoma of the Nervous System
C22034	Solitary_Fibrous_Tumour_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System	Solitary Fibrous Tumour of the Mouse Nervous System|GEM Solitary fibrous tumour|Solitary Fibrous Tumour of the Nervous System
C22035	Fibrosarcoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System	Fibrosarcoma of the Mouse Nervous System|Fibrosarcoma of the Nervous System|GEM Fibrosarcoma|Oligodendroglioma Grade II
C22036	Malignant_Fibrous_Histiocytoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System	Malignant Fibrous Histiocytoma of the Mouse Nervous System|GEM Malignant fibrous histiocytoma|Malignant Fibrous Histiocytoma of the Nervous System
C22037	Leiomyoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System|Mouse_Leiomyoma	Leiomyoma of the Mouse Nervous System|GEM Leiomyoma|Leiomyoma of the Nervous System
C22038	Leiomyosarcoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System|Mouse_Leiomyosarcoma	Leiomyosarcoma of the Mouse Nervous System|GEM Leiomyosarcoma|Leiomyosarcoma of the Nervous System
C22039	Rhabdomyoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System	Rhabdomyoma of the Mouse Nervous System|GEM Rhabdomyoma|Rhabdomyoma of the Nervous System
C22040	Rhabdomyosarcoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System	Rhabdomyosarcoma of the Mouse Nervous System|GEM Rhabdomyosarcoma|Rhabdomyosarcoma of the Nervous System
C22041	Chondroma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System	Chondroma of the Mouse Nervous System|Astrocytoma Grade II, Astrocytoma|Chondroma of the Nervous System|GEM Chondroma
C22042	Chondrosarcoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System|Mouse_Chondrosarcoma	Chondrosarcoma of the Mouse Nervous System|Astrocytoma Grade III|Chondrosarcoma of the Nervous System|GEM Chondrosarcoma
C22043	Osteoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System	Osteoma of the Mouse Nervous System|GEM Osteoma|Osteoma of the Nervous System
C22044	Osteosarcoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System|Mouse_Osteosarcoma	Osteosarcoma of the Mouse Nervous System|GEM Osteosarcoma|Osteosarcoma of the Nervous System
C22045	Osteochondroma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System	Osteochondroma of the Mouse Nervous System|GEM Osteochondroma|Osteochondroma of the Nervous System
C22046	Haemangioma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System	Haemangioma of the Mouse Nervous System|GEM Haemangioma|Haemangioma of the Nervous System|Hemangioma; angioma
C22047	Epithelioid_Haemangioendothelioma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System	Epithelioid Haemangioendothelioma of the Mouse Nervous System|Epithelioid Haemangioendothelioma of the Nervous System|Epithelioid hemangioendothelioma; epithelioid angioendothelioma|GEM Epithelioid haemangioendothelioma|Glial Neoplasm Grade III
C22048	Haemangiopericytoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System	Haemangiopericytoma of the Mouse Nervous System|GEM Haemangiopericytoma|Haemangiopericytoma of the Nervous System|Hemangiopericytoma
C22049	Angiosarcoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System|Mouse_Sarcoma	Angiosarcoma of the Mouse Nervous System|Angiosarcoma of the Nervous System|Astrocytoma Grade II|GEM Angiosarcoma|hemangiosarcoma
C22050	Kaposi_Sarcoma_of_the_Mouse_Nervous_System	Mesenchymal_Non-meningothelial_Tumours_of_the_Mouse_Nervous_System|Mouse_Sarcoma	Kaposi Sarcoma of the Mouse Nervous System|GEM Kaposi sarcoma|Kaposi Sarcoma of the Nervous System
C22051	Primary_Melanocytic_Lesions_of_the_Mouse_Nervous_System	Mouse_Melanocyte_Neoplasm|Tumors_of_the_Mouse_Meninges	Primary Melanocytic Lesions of the Mouse Nervous System|GEM Primary melanocytic lesions|Primary Melanocytic Lesions of the Nervous System
C22052	Diffuse_Melanocytosis_of_the_Mouse_Nervous_System	Primary_Melanocytic_Lesions_of_the_Mouse_Nervous_System	Diffuse Melanocytosis of the Mouse Nervous System|Astrocytoma Grade IV|Diffuse Melanocytosis of the Nervous System|GEM Diffuse melanocytosis
C22053	Melanocytoma_of_the_Mouse_Nervous_System	Primary_Melanocytic_Lesions_of_the_Mouse_Nervous_System	Melanocytoma of the Mouse Nervous System|GEM Melanocytoma|Melanocytoma of the Nervous System
C22054	Malignant_Melanoma_of_the_Mouse_Nervous_System	Primary_Melanocytic_Lesions_of_the_Mouse_Nervous_System	Malignant Melanoma of the Mouse Nervous System|GEM Malignant melanoma|Malignant Melanoma of the Nervous System
C22055	Mouse_Meningeal_Melanomatosis	Primary_Melanocytic_Lesions_of_the_Mouse_Nervous_System	Mouse Meningeal Melanomatosis|GEM Meningeal melanomatosis|Meningeal Melanomatosis
C22056	Mouse_Nervous_System_Tumors_of_Uncertain_Histogenesis	Tumors_of_the_Mouse_Meninges	Mouse Nervous System Tumors of Uncertain Histogenesis|GEM Tumours of uncertain histogenesis|Nervous System Tumors of Uncertain Histogenesis
C22057	Mouse_Hemangioblastoma	Mouse_Nervous_System_Tumors_of_Uncertain_Histogenesis	Mouse Hemangioblastoma|GEM Haemangioblastoma|Hemangioblastoma|Hemangioblastoma; angioblastoma
C22058	Lymphomas_and_Haemopoietic_Neoplasms_of_the_Mouse_Nervous_System	Mouse_Lymph_Cell_Neoplasm|Mouse_Nervous_System_Neoplasms	Lymphomas and Haemopoietic Neoplasms of the Mouse Nervous System|GEM LYMPHOMAS AND HAEMOPOIETIC NEOPLASMS|Lymphomas and Haemopoietic Neoplasms of the Nervous System
C22059	Malignant_Lymphomas_of_the_Mouse_Nervous_System	Lymphomas_and_Haemopoietic_Neoplasms_of_the_Mouse_Nervous_System|Mouse_Lymphoma	Malignant Lymphomas of the Mouse Nervous System|GEM Malignant lymphomas|Malignant Lymphomas of the Nervous System
C22060	Plasmacytoma_of_the_Mouse_Nervous_System	Lymphomas_and_Haemopoietic_Neoplasms_of_the_Mouse_Nervous_System	Plasmacytoma of the Mouse Nervous System|GEM Plasmacytoma|Plasma cell tumor; plasma cell neoplasm; Solitary myeloma|Plasmacytoma of the Nervous System
C22061	Granulocytic_Sarcoma_of_the_Mouse_Nervous_System	Lymphomas_and_Haemopoietic_Neoplasms_of_the_Mouse_Nervous_System|Mouse_Sarcoma	Granulocytic Sarcoma of the Mouse Nervous System|Chloroma|GEM Granulocytic sarcoma|Granulocytic Sarcoma of the Nervous System
C22062	Germ_Cell_Tumors_of_the_Mouse_Nervous_System	Mouse_Germ_Cell_Neoplasm|Mouse_Nervous_System_Neoplasms	Germ Cell Tumors of the Mouse Nervous System|GEM GERM CELL TUMOURS|Germ Cell Tumors of the Nervous System|Oligodendroglioma Grade III
C22063	Germinoma_of_the_Mouse_Nervous_System	Germ_Cell_Tumors_of_the_Mouse_Nervous_System	Germinoma of the Mouse Nervous System|GEM Germinoma|Germinoma of the Nervous System
C22064	Embryonal_Carcinoma_of_the_Mouse_Nervous_System	Germ_Cell_Tumors_of_the_Mouse_Nervous_System|Mouse_Carcinoma	Embryonal Carcinoma of the Mouse Nervous System|Embryonal Carcinoma of the Nervous System|GEM Embryonal carcinoma|Glial Neoplasm Grade II
C22065	Yolk_Sac_Tumour_of_the_Mouse_Nervous_System	Germ_Cell_Tumors_of_the_Mouse_Nervous_System	Yolk Sac Tumour of the Mouse Nervous System|GEM Yolk sac tumour|Yolk Sac Tumour of the Nervous System|endodermal sinus neoplasm
C22066	Choriocarcinoma_of_the_Mouse_Nervous_System	Germ_Cell_Tumors_of_the_Mouse_Nervous_System	Choriocarcinoma of the Mouse Nervous System|Astrocytoma Grade IV|Choriocarcinoma of the Nervous System|GEM Choriocarcinoma
C22067	Teratoma_of_the_Mouse_Nervous_System	Germ_Cell_Tumors_of_the_Mouse_Nervous_System	Teratoma of the Mouse Nervous System|GEM Teratoma|Teratoma of the Nervous System
C22068	Mature_Teratoma_of_the_Mouse_Nervous_System	Teratoma_of_the_Mouse_Nervous_System	Mature Teratoma of the Mouse Nervous System|GEM Mature teratoma|Mature Teratoma of the Nervous System
C22069	Immature_Teratoma_of_the_Mouse_Nervous_System	Teratoma_of_the_Mouse_Nervous_System	Immature Teratoma of the Mouse Nervous System|GEM Immature teratoma|Immature Teratoma of the Nervous System
C22070	Teratoma_of_the_Mouse_Nervous_System_with_Malignant_Transformation	Teratoma_of_the_Mouse_Nervous_System	Teratoma of the Mouse Nervous System with Malignant Transformation|GEM Teratoma with malignant transformation|Teratoma of the Nervous System with Malignant Transformation
C22071	Mixed_Germ_Cell_Tumours_of_the_Mouse_Nervous_System	Germ_Cell_Tumors_of_the_Mouse_Nervous_System	Mixed Germ Cell Tumours of the Mouse Nervous System|GEM Mixed germ cell tumours|Mixed Germ Cell Tumours of the Nervous System|mixed germ cell neoplasm
C22072	Tumors_of_the_Mouse_Sellar_Region	Mouse_Nervous_System_Neoplasms	Tumors of the Mouse Sellar Region|GEM TUMOURS OF THE SELLAR REGION|Tumors of the Sellar Region
C22073	Mouse_Craniopharyngioma	Tumors_of_the_Mouse_Sellar_Region	Mouse Craniopharyngioma|Craniopharyngioma|GEM Craniopharyngioma|neoplasm of rathke's pouch; rathke's pouch tumor	A neoplasm or the cellar region presumed to be derived from Rathke's pouch epithelial cells.  Often cystic with a well demarcated pushing margin.
C22074	Mouse_Adamantinomatous_Craniopharyngioma	Mouse_Craniopharyngioma	Mouse Adamantinomatous Craniopharyngioma|Adamantinomatous Craniopharyngioma|Adamantinomatous neoplasm of rathke's pouch; Adamantinomatous rathke's pouch tumor|GEM Adamantinomatous craniopharyngioma
C22075	Mouse_Papillary_Craniopharyngioma	Mouse_Craniopharyngioma	Mouse Papillary Craniopharyngioma|GEM Papillary craniopharyngioma|Papillary Craniopharyngioma|papillary neoplasm of rathke's pouch; papillary rathke's pouch tumor
C22076	Granular_Cell_Tumor_of_the_Mouse_Sellar_Region	Tumors_of_the_Mouse_Sellar_Region	Granular Cell Tumor of the Mouse Sellar Region|GEM Granular cell tumour|Granular Cell Tumor of the Sellar Region
C22077	Metastatic_Tumours_of_the_Mouse_Nervous_System	Mouse_Metastatic_Neoplasms	Metastatic Tumours of the Mouse Nervous System|METASTATIC TUMOURS|Metastatic Tumours of the Nervous System
C22078	Inflammatory_Diseases_of_the_Mouse_Intestinal_Tract	Mouse_Digestive_System_Disorder|Mouse_Noncancerous_Conditions	Inflammatory Diseases of the Mouse Intestinal Tract|Inflammatory Diseases of the Intestinal Tract	The intestinal tract has an increased number of inflammatory cells.
C22079	Acute_Enteritis_of_the_Mouse_Intestinal_Tract	Inflammatory_Diseases_of_the_Mouse_Intestinal_Tract	Acute Enteritis of the Mouse Intestinal Tract|Acute Enteritis|Colitis|Duodenitis|Enteritis|Jejunitis|Typhlitis|duodenitis	Inflammatory cells are composed of primarily neutrophils or eosinophils typically associated with little other damage to the intestinal tract
C22080	Focal_Acute_Enteritis_of_the_Mouse_Intestinal_Tract	Acute_Enteritis_of_the_Mouse_Intestinal_Tract	Focal Acute Enteritis of the Mouse Intestinal Tract|Focal Acute Enteritis	The inflammation is localized to a focal area or discrete region.
C22081	Focal_Acute_Suppurative_Enteritis_of_the_Mouse_Intestinal_Tract	Focal_Acute_Enteritis_of_the_Mouse_Intestinal_Tract	Focal Acute Suppurative Enteritis of the Mouse Intestinal Tract|Focal Acute Suppurative Enteritis	Inflammation consists of neutrophils.
C22082	Focal_Acute_Eosinophilic_Enteritis_of_the_Mouse_Intestinal_Tract	Focal_Acute_Enteritis_of_the_Mouse_Intestinal_Tract	Focal Acute Eosinophilic Enteritis of the Mouse Intestinal Tract|Focal Acute Eosinophilic Enteritis	Inflammation consists of eosinophils
C22083	Diffuse_Acute_Enteritis_of_the_Mouse_Intestinal_Tract	Acute_Enteritis_of_the_Mouse_Intestinal_Tract	Diffuse Acute Enteritis of the Mouse Intestinal Tract|Diffuse Acute Enteritis	The inflammation is spread over a large area of the intestinal tract.
C22084	Diffuse_Acute_Suppurative_Enteritis_of_the_Mouse_Intestinal_Tract	Diffuse_Acute_Enteritis_of_the_Mouse_Intestinal_Tract	Diffuse Acute Suppurative Enteritis of the Mouse Intestinal Tract|Diffuse Acute Suppurative Enteritis	Inflammation is composed of neutrophils.
C22085	Diffuse_Acute_Eosinophilic_Enteritis_of_the_Mouse_Intestinal_Tract	Diffuse_Acute_Enteritis_of_the_Mouse_Intestinal_Tract	Diffuse Acute Eosinophilic Enteritis of the Mouse Intestinal Tract|Diffuse Acute Eosinophilic Enteritis	Inflammation is composed of eosinophils.
C22086	Acute_Ulcerative_Enteritis_of_the_Mouse_Intestinal_Tract	Acute_Enteritis_of_the_Mouse_Intestinal_Tract	Acute Ulcerative Enteritis of the Mouse Intestinal Tract|Acute Ulcerative Enteritis|Inflammatory Bowel Disease	This is a combination of ulceration, hyperplasia and inflammation of the intestinal mucosa.
C22087	Chronic_Enteritis_of_the_Mouse_Intestinal_Tract	Inflammatory_Diseases_of_the_Mouse_Intestinal_Tract	Chronic Enteritis of the Mouse Intestinal Tract|Chronic Enteritis	The inflammatory is composed of lymphocytes and or macrophages. It may also have acute inflammation associated with the lesions.  There may be associated mucosal damage and hyperplasia associated with the inflammation.
C22088	Focal_Chronic_Enteritis_of_the_Mouse_Intestinal_Tract	Chronic_Enteritis_of_the_Mouse_Intestinal_Tract	Focal Chronic Enteritis of the Mouse Intestinal Tract|Focal Chronic Enteritis	Inflammation is limited to a focal area or discrete region.
C22089	Focal_Chronic_Granulomatous_Enteritis_of_the_Mouse_Intestinal_Tract	Focal_Chronic_Enteritis_of_the_Mouse_Intestinal_Tract	Focal Chronic Granulomatous Enteritis of the Mouse Intestinal Tract|Focal Chronic Granulomatous Enteritis	Inflammation is composed of neutrophils and epithelioid macrophages.
C22090	Focal_Chronic_Lymphoplasmacytic_Enteritis_of_the_Mouse_Intestinal_Tract	Focal_Chronic_Enteritis_of_the_Mouse_Intestinal_Tract	Focal Chronic Lymphoplasmacytic Enteritis of the Mouse Intestinal Tract|Focal Chronic Lymphoplasmacytic Enteritis	Inflammation is primarily composed of lymphocytes and plasma cells.
C22091	Diffuse_Chronic_Enteritis_of_the_Mouse_Intestinal_Tract	Chronic_Enteritis_of_the_Mouse_Intestinal_Tract	Diffuse Chronic Enteritis of the Mouse Intestinal Tract|Diffuse Chronic Enteritis	The inflammation is spread over a large area of the intestinal tract.
C22092	Diffuse_Chronic_Granulomatous_Enteritis_of_the_Mouse_Intestinal_Tract	Diffuse_Chronic_Enteritis_of_the_Mouse_Intestinal_Tract	Diffuse Chronic Granulomatous Enteritis of the Mouse Intestinal Tract|Diffuse Chronic Granulomatous Enteritis	Inflammation is composed of neutrophils and epithelioid macrophages.
C22093	Diffuse_Chronic_Lymphoplasmacytic_Enteritis_of_the_Mouse_Intestinal_Tract	Diffuse_Chronic_Enteritis_of_the_Mouse_Intestinal_Tract	Diffuse Chronic Lymphoplasmacytic Enteritis of the Mouse Intestinal Tract|Diffuse Chronic Lymphoplasmacytic Enteritis	Inflammation is primarily composed of lymphocytes and plasma cells.
C22094	Chronic_Ulcerative_Enteritis_of_the_Mouse_Intestinal_Tract	Chronic_Enteritis_of_the_Mouse_Intestinal_Tract	Chronic Ulcerative Enteritis of the Mouse Intestinal Tract|Chronic Ulcerative Enteritis	This is a combination of ulceration, hyperplasia and chronic inflammation of the intestinal mucosa.
C22095	Necrotizing_Enteritis_of_the_Mouse_Intestinal_Tract	Inflammatory_Diseases_of_the_Mouse_Intestinal_Tract	Necrotizing Enteritis of the Mouse Intestinal Tract|Necrotizing Enteritis	The disease is a combination of necrosis of the mucosa with inflammation.
C22096	Hyperplasia_of_the_Mouse_Intestinal_Tract	Mouse_Cancer-Related_Conditions|Mouse_Digestive_System_Disorder	Hyperplasia of the Mouse Intestinal Tract|Hyperplasia of the Intestinal Tract	An increase in parenchymal cell number.
C22097	Mucosal_Hyperplasia_of_the_Mouse_Intestinal_Tract	Hyperplasia_of_the_Mouse_Intestinal_Tract	Mucosal Hyperplasia of the Mouse Intestinal Tract|Mucosal Hyperplasia of the Intestinal Tract	An increase in any epithelial cells of the intestinal mucosa appearing as elongated villi or crypts. Cells are characterized by columnar shape, crowding, and generally basal located nuclei.
C22098	Focal_Mucosal_Hyperplasia_of_the_Mouse_Intestinal_Tract	Mucosal_Hyperplasia_of_the_Mouse_Intestinal_Tract	Focal Mucosal Hyperplasia of the Mouse Intestinal Tract|Focal Mucosal Hyperplasia of the Intestinal Tract	The increase in cell numbers is localized to a few (1-5) adjacent crypts
C22099	Diffuse_Mucosal_Hyperplasia_of_the_Mouse_Intestinal_Tract	Mucosal_Hyperplasia_of_the_Mouse_Intestinal_Tract	Diffuse Mucosal Hyperplasia of the Mouse Intestinal Tract|Diffuse Mucosal Hyperplasia of the Intestinal Tract	The increase in cell numbers is located in widespread crypts
C22100	Lymphoid_Hyperplasia_of_the_Mouse_Intestinal_Tract	Hyperplasia_of_the_Mouse_Intestinal_Tract	Lymphoid Hyperplasia of the Mouse Intestinal Tract|Lymphoid Hyperplasia of the Intestinal Tract	Proliferation of the lymphoid population isolated to the GALT (Gut Associated Lymphoid Tissue). GALT retains normal architecture.
C22101	Neuroendocrine_Cell_Hyperplasia_of_the_Mouse_Intestinal_Tract	Hyperplasia_of_the_Mouse_Intestinal_Tract	Neuroendocrine Cell Hyperplasia of the Mouse Intestinal Tract|Neuroendocrine Cell Hyperplasia of the Intestinal Tract	Proliferation of the neuroendocrine cells isolated to the base of the crypts. Cells retain normal architecture. Proliferating cells are mixed with other mucosal cells.
C22102	Benign_Conditions_of_the_Mouse_Intestinal_Tract	Mouse_Digestive_System_Disorder|Mouse_Noncancerous_Conditions	Benign Conditions of the Mouse Intestinal Tract|Benign Conditions of the Intestinal Tract	Autonomous new growth of the intestinal epithelium that has limited growth potential and does not metastasize to surrounding structures. Cells do not penetrate the basement membrane.
C22103	Mucosal_Herniation_of_the_Mouse_Intestinal_Tract	Benign_Conditions_of_the_Mouse_Intestinal_Tract	Mucosal Herniation of the Mouse Intestinal Tract|Mucosal Herniation of the Intestinal Tract	Extension of the normal mucosa into and through the muscular wall and maintaining differentiation of the mucosal cell types.
C22104	Hamartoma_of_the_Mouse_Intestinal_Tract	Benign_Conditions_of_the_Mouse_Intestinal_Tract	Hamartoma of the Mouse Intestinal Tract|Hamartoma of the Intestinal Tract	Normal tissue located in an abnormal location.
C22105	Congestion_of_the_Mouse_Intestinal_Tract	Benign_Conditions_of_the_Mouse_Intestinal_Tract	Congestion of the Mouse Intestinal Tract|Congestion of the Intestinal Tract	Increased blood in the vasculature of the mucosa. Blood vessels are distended and prominent.
C22106	Focal_Congestion_of_the_Mouse_Intestinal_Tract	Congestion_of_the_Mouse_Intestinal_Tract	Focal Congestion of the Mouse Intestinal Tract|Focal Congestion of the Intestinal Tract	Congestion is isolated to a limited area in the mucosa.
C22107	Diffuse_Congestion_of_the_Mouse_Intestinal_Tract	Congestion_of_the_Mouse_Intestinal_Tract	Diffuse Congestion of the Mouse Intestinal Tract|Diffuse Congestion of the Intestinal Tract	Congestion is widespread over an extended area of the intestine.
C22108	Squamous_Metaplasia_of_the_Mouse_Intestinal_Tract	Benign_Conditions_of_the_Mouse_Intestinal_Tract	Squamous Metaplasia of the Mouse Intestinal Tract|Squamous Metaplasia of the Intestinal Tract	Differentiation of the intestinal mucosa into cells that have the following characteristics: cuboidal to polygonal or flattened shape, non-secretory, and abundant pink cytoplasm.  Cells are positive for cytokeratins associated with squamous differentiation.
C22109	Erosion_of_the_Mouse_Intestinal_Tract	Benign_Conditions_of_the_Mouse_Intestinal_Tract	Erosion of the Mouse Intestinal Tract|Erosion of the Intestinal Tract	Loss of surface mucosa with or without inflammation.
C22110	Mucosal_Atrophy_of_the_Mouse_Intestinal_Tract	Benign_Conditions_of_the_Mouse_Intestinal_Tract	Mucosal Atrophy of the Mouse Intestinal Tract|Mucosal Atrophy of the Intestinal Tract	Decrease in parenchymal cell number and/or size, often associated with shortening of villi (SI) and/or glands (LI)
C22111	Ulceration_of_the_Mouse_Intestinal_Tract	Benign_Conditions_of_the_Mouse_Intestinal_Tract	Ulceration of the Mouse Intestinal Tract|Ulceration of the Intestinal Tract	Loss of mucosa to the muscular wall.
C22112	Glandular_Cystic_Dilation_of_the_Mouse_Intestinal_Tract	Benign_Conditions_of_the_Mouse_Intestinal_Tract	Glandular Cystic Dilation of the Mouse Intestinal Tract|Glandular Cystic Dilation of the Intestinal Tract	Dilation of the glandular unit with compression of the epithelium.
C22113	Preneoplastic_Lesions_of_the_Mouse_Intestinal_Tract	Mouse_Digestive_System_Disorder|Mouse_Precancerous_Conditions	Preneoplastic Lesions of the Mouse Intestinal Tract|Preneoplastic Lesions of the Intestinal Tract	Reversible increase in cell number of epithelial origin.  Lesions are known to potentially progress to neoplasms.
C22114	Aberrant_Crypt_Foci_of_the_Mouse_Intestinal_Tract	Preneoplastic_Lesions_of_the_Mouse_Intestinal_Tract	Aberrant Crypt Foci of the Mouse Intestinal Tract|Aberrant Crypt Foci	Cells are methylene blue positive on whole mounts, cells have basophilic cytoplasm on H and E stain, and may have Beta-catenin staining in the nucleus.
C22115	Neoplasms_of_the_Mouse_Intestinal_Tract	Mouse_Gastrointestinal_System_Neoplasms	Neoplasms of the Mouse Intestinal Tract|Neoplasms of the Intestinal Tract	A new formation of tissue that does not subserve a physiologic purpose, has unregulated growth, exhibits cellular characteristics resembling cells of gastrointestinal lineage, and grows autonomously.
C22116	Gastrointestinal_Intraepithelial_Neoplasia_of_Mouse	Mouse_Intraepithelial_Neoplasia|Neoplasms_of_the_Mouse_Intestinal_Tract	Gastrointestinal Intraepithelial Neoplasia of Mouse|GIN|Gastro-Intestinal Intraepithelial Neoplasia|Gastrointestinal Carcinoma in Situ|Gastrointestinal Foci of Atypical Hyperplasia|Gastrointestinal Intraepithelial Neoplasia|Gastrointestinal Microadenoma	Potential for malignancy in GIN cannot be assessed morphologically, hence the separation of this term from large Benign and Malignant categories.
C22117	Benign_Neoplasms_of_the_Mouse_Intestinal_Tract	Neoplasms_of_the_Mouse_Intestinal_Tract	Benign Neoplasms of the Mouse Intestinal Tract|Benign Neoplasms of the Intestinal Tract
C22118	Adenoma_of_the_Mouse_Intestinal_Tract	Benign_Neoplasms_of_the_Mouse_Intestinal_Tract|Mouse_Adenoma	Adenoma of the Mouse Intestinal Tract|Adenoma of the Intestinal Tract	A benign (well differentiated) neoplastic proliferation of glandular tissue with a non-invasive, expansile margin.  Cell features include nuclei that are not basally located and have increased size, and there may be cell layering. Lesions must be visible grossly (greater than 0.5mm).
C22119	Sessile_Adenoma_of_the_Mouse_Intestinal_Tract	Adenoma_of_the_Mouse_Intestinal_Tract	Sessile Adenoma of the Mouse Intestinal Tract|Sessile Adenoma of the Intestinal Tract	Grossly and microscopically tumors have a broad base
C22120	Sessile_Tubular_Adenoma_of_the_Mouse_Intestinal_Tract	Sessile_Adenoma_of_the_Mouse_Intestinal_Tract	Sessile Tubular Adenoma of the Mouse Intestinal Tract|Sessile Tubular Adenoma|Sessile Tubular Adenoma of the Intestinal Tract	Branching tubules surrounded by lamina propria, comprising at least 80% of the tumor. Majority of glands are parallel to the mucosal surface with complex branching patterns.
C22121	Low_Grade_Sessile_Tubular_Dysplasia_of_the_Mouse_Intestinal_Tract	Sessile_Tubular_Adenoma_of_the_Mouse_Intestinal_Tract	Low Grade Sessile Tubular Dysplasia of the Mouse Intestinal Tract|Low Grade Sessile Tubular Dysplasia|Low Grade Sessile Tubular Dysplasia of the Intestinal Tract	Branching or elongation of crypts with some reduction of interglandular stroma containing cells with low nuclear to cytoplasm ratio. Cell nuclei are elongated, crowded, appear stratified and basally located with regular nuclear membranes, fine chromatin, and inconspicuous nucleoli.  Mucus secretion is usually present.
C22122	High_Grade_Sessile_Tubular_Dysplasia_of_the_Mouse_Intestinal_Tract	Sessile_Tubular_Adenoma_of_the_Mouse_Intestinal_Tract	High Grade Sessile Tubular Dysplasia of the Mouse Intestinal Tract|High Grade Sessile Tubular Dysplasia|High Grade Sessile Tubular Dysplasia of the Intestinal Tract	There are both architectural and cytologic changes. There is marked reduction of interglandular stroma with complex irregularity of glands.  There is a high nuclear to cytoplasm ratio.  The cell nuclei are large, ovoid to round and are not basally located with marked irregular nuclear membranes, cleared, vesicular, clumped, or densely hyperchromatic chromatin, and large conspicuous nucleoli.  Mucus is typically absent.  Mitotic activity is prominent.
C22123	Sessile_Villous_Adenoma_of_the_Mouse_Intestinal_Tract	Sessile_Adenoma_of_the_Mouse_Intestinal_Tract	Sessile Villous Adenoma of the Mouse Intestinal Tract|Sessile Papillary Adenoma|Sessile Villous Adenoma|Sessile Villous Adenoma of the Intestinal Tract	Majority of glands (greater than 75%) are leaf- or finger- like processes of lamina propria covered by dysplastic epithelium.
C22124	Low_Grade_Sessile_Villous_Dysplasia_of_the_Mouse_Intestinal_Tract	Sessile_Villous_Adenoma_of_the_Mouse_Intestinal_Tract	Low Grade Sessile Villous Dysplasia of the Mouse Intestinal Tract|Low Grade Sessile Villous Dysplasia|Low Grade Sessile Villous Dysplasia of the Intestinal Tract	Branching or elongation of crypts with some reduction of interglandular stroma containing cells with low nuclear to cytoplasm ratio. Cell nuclei are elongated, crowded, appear stratified and basally located with regular nuclear membranes, fine chromatin, and inconspicuous nucleoli.  Mucus secretion is usually present.
C22125	High_Grade_Sessile_Villous_Dysplasia_of_the_Mouse_Intestinal_Tract	Sessile_Villous_Adenoma_of_the_Mouse_Intestinal_Tract	High Grade Sessile Villous Dysplasia of the Mouse Intestinal Tract|High Grade Sessile Villous Dysplasia of the Intestinal Tract	There are both architectural and cytologic changes. There is marked reduction of interglandular stroma with complex irregularity of glands.  There is a high nuclear to cytoplasm ratio.  The cell nuclei are large, ovoid to round and are not basally located with marked irregular nuclear membranes, cleared, vesicular, clumped, or densely hyperchromatic chromatin, and large conspicuous nucleoli.  Mucus is typically absent.  Mitotic activity is prominent.
C22126	Sessile_Tubulovillous_Adenoma_of_the_Mouse_Intestinal_Tract	Sessile_Adenoma_of_the_Mouse_Intestinal_Tract	Sessile Tubulovillous Adenoma of the Mouse Intestinal Tract|Sessile Tubulovillous Adenoma|Sessile Tubulovillous Adenoma of the Intestinal Tract	Containing features of both tubular and villous components.  Each comprise more than 20% of the tumor
C22127	Low_Grade_Sessile_Tubulovillous_Dysplasia_of_the_Mouse_Intestinal_Tract	Sessile_Tubulovillous_Adenoma_of_the_Mouse_Intestinal_Tract	Low Grade Sessile Tubulovillous Dysplasia of the Mouse Intestinal Tract|Low Grade Sessile Tubulovillous Dysplasia|Low Grade Sessile Tubulovillous Dysplasia of the Intestinal Tract	Branching or elongation of crypts with some reduction of interglandular stroma containing cells with low nuclear to cytoplasm ratio. Cell nuclei are elongated, crowded, appear stratified and basally located with regular nuclear membranes, fine chromatin, and inconspicuous nucleoli.  Mucus secretion is usually present.
C22128	High_Grade_Sessile_Tubulovillous_Dysplasia_of_the_Mouse_Intestinal_Tract	Sessile_Tubulovillous_Adenoma_of_the_Mouse_Intestinal_Tract	High Grade Sessile Tubulovillous Dysplasia of the Mouse Intestinal Tract|High Grade Sessile Tubulovillous Dysplasia|High Grade Sessile Tubulovillous Dysplasia of the Intestinal Tract	There are both architectural and cytologic changes. There is marked reduction of interglandular stroma with complex irregularity of glands.  There is a high nuclear to cytoplasm ratio.  The cell nuclei are large, ovoid to round and are not basally located with marked irregular nuclear membranes, cleared, vesicular, clumped, or densely hyperchromatic chromatin, and large conspicuous nucleoli.  Mucus is typically absent.  Mitotic activity is prominent.
C22129	Flat_Adenoma_of_the_Mouse_Intestinal_Tract	Adenoma_of_the_Mouse_Intestinal_Tract	Flat Adenoma of the Mouse Intestinal Tract|Flat Adenoma|Flat Adenoma of the Intestinal Tract	Tumor are less than 2 times the height of the mucosa and does not have a stalk.
C22130	Flat_Tubular_Adenoma_of_the_Mouse_Intestinal_Tract	Flat_Adenoma_of_the_Mouse_Intestinal_Tract	Flat Tubular Adenoma of the Mouse Intestinal Tract|Flat Tubular Adenoma|Flat Tubular Adenoma of the Intestinal Tract	Branching tubules surrounded by lamina propria, comprising at least 80% of the tumor. Majority of glands are parallel to the mucosal surface with complex branching patterns.
C22131	Low_Grade_Flat_Tubular_Dysplasia_of_the_Mouse_Intestinal_Tract	Flat_Tubular_Adenoma_of_the_Mouse_Intestinal_Tract	Low Grade Flat Tubular Dysplasia of the Mouse Intestinal Tract|Low Grade Flat Tubular Dysplasia|Low Grade Flat Tubular Dysplasia of the Intestinal Tract	Branching or elongation of crypts with some reduction of interglandular stroma containing cells with low nuclear to cytoplasm ratio. Cell nuclei are elongated, crowded, appear stratified and basally located with regular nuclear membranes, fine chromatin, and inconspicuous nucleoli.  Mucus secretion is usually present.
C22132	High_Grade_Flat_Tubular_Dysplasia_of_the_Mouse_Intestinal_Tract	Flat_Tubular_Adenoma_of_the_Mouse_Intestinal_Tract	High Grade Flat Tubular Dysplasia of the Mouse Intestinal Tract|High Grade Flat Tubular Dysplasia|High Grade Flat Tubular Dysplasia of the Intestinal Tract	There are both architectural and cytologic changes. There is marked reduction of interglandular stroma with complex irregularity of glands.  There is a high nuclear to cytoplasm ratio.  The cell nuclei are large, ovoid to round and are not basally located with marked irregular nuclear membranes, cleared, vesicular, clumped, or densely hyperchromatic chromatin, and large conspicuous nucleoli.  Mucus is typically absent.  Mitotic activity is prominent.
C22133	Flat_Villous_Adenoma_of_the_Mouse_Intestinal_Tract	Flat_Adenoma_of_the_Mouse_Intestinal_Tract	Flat Villous Adenoma of the Mouse Intestinal Tract|Flat Villous Adenoma|Flat Villous Adenoma of the Intestinal Tract	Majority of glands (greater than 75%) are leaf- or finger- like processes of lamina propria covered by dysplastic epithelium.
C22134	Low_Grade_Flat_Villous_Dysplasia_of_the_Mouse_Intestinal_Tract	Flat_Villous_Adenoma_of_the_Mouse_Intestinal_Tract	Low Grade Flat Villous Dysplasia of the Mouse Intestinal Tract|Low Grade Flat Villous Dysplasia|Low Grade Flat Villous Dysplasia of the Intestinal Tract	Branching or elongation of crypts with some reduction of interglandular stroma containing cells with low nuclear to cytoplasm ratio. Cell nuclei are elongated, crowded, appear stratified and basally located with regular nuclear membranes, fine chromatin, and inconspicuous nucleoli.  Mucus secretion is usually present.
C22135	High_Grade_Flat_Villous_Dysplasia_of_the_Mouse_Intestinal_Tract	Flat_Villous_Adenoma_of_the_Mouse_Intestinal_Tract	High Grade Flat Villous Dysplasia of the Mouse Intestinal Tract|High Grade Flat Villous Dysplasia|High Grade Flat Villous Dysplasia of the Intestinal Tract	There are both architectural and cytologic changes. There is marked reduction of interglandular stroma with complex irregularity of glands.  There is a high nuclear to cytoplasm ratio.  The cell nuclei are large, ovoid to round and are not basally located with marked irregular nuclear membranes, cleared, vesicular, clumped, or densely hyperchromatic chromatin, and large conspicuous nucleoli.  Mucus is typically absent.  Mitotic activity is prominent.
C22136	Flat_Tubulovillous_Adenoma_of_the_Mouse_Intestinal_Tract	Flat_Adenoma_of_the_Mouse_Intestinal_Tract	Flat Tubulovillous Adenoma of the Mouse Intestinal Tract|Flat Tubulovillous Adenoma|Flat Tubulovillous Adenoma of the Intestinal Tract	Containing features of both tubular and villous components.  Each comprise more than 20% of the tumor
C22137	Low_Grade_Flat_Tubulovillous_Dysplasia_of_the_Mouse_Intestinal_Tract	Flat_Tubulovillous_Adenoma_of_the_Mouse_Intestinal_Tract	Low Grade Flat Tubulovillous Dysplasia of the Mouse Intestinal Tract|Low Grade Flat Tubulovillous Dysplasia|Low Grade Flat Tubulovillous Dysplasia of the Intestinal Tract	Branching or elongation of crypts with some reduction of interglandular stroma containing cells with low nuclear to cytoplasm ratio. Cell nuclei are elongated, crowded, appear stratified and basally located with regular nuclear membranes, fine chromatin, and inconspicuous nucleoli.  Mucus secretion is usually present.
C22138	High_Grade_Flat_Tubulovillous_Dysplasia_of_the_Mouse_Intestinal_Tract	Flat_Tubulovillous_Adenoma_of_the_Mouse_Intestinal_Tract	High Grade Flat Tubulovillous Dysplasia of the Mouse Intestinal Tract|High Grade Flat Tubulovillous Dysplasia|High Grade Flat Tubulovillous Dysplasia of the Intestinal Tract	There are both architectural and cytologic changes. There is marked reduction of interglandular stroma with complex irregularity of glands.  There is a high nuclear to cytoplasm ratio.  The cell nuclei are large, ovoid to round and are not basally located with marked irregular nuclear membranes, cleared, vesicular, clumped, or densely hyperchromatic chromatin, and large conspicuous nucleoli.  Mucus is typically absent.  Mitotic activity is prominent.
C22139	Pedunculated_Adenoma_of_the_Mouse_Intestinal_Tract	Adenoma_of_the_Mouse_Intestinal_Tract	Pedunculated Adenoma of the Mouse Intestinal Tract|Adenomatous Polyp|Pedunculated Adenoma|Pedunculated Adenoma of the Intestinal Tract	The adenoma is attached by a stalk that is less in diameter than the overlying tumor.
C22140	Pedunculated_Tubular_Adenoma_of_the_Mouse_Intestinal_Tract	Pedunculated_Adenoma_of_the_Mouse_Intestinal_Tract	Pedunculated Tubular Adenoma of the Mouse Intestinal Tract|Pedunculated Tubular Adenoma|Pedunculated Tubular Adenoma of the Intestinal Tract	Branching tubules surrounded by lamina propria, comprising at least 80% of the tumor. Majority of glands are parallel to the mucosal surface with complex branching patterns.
C22141	Low_Grade_Pedunculated_Tubular_Dysplasia_of_the_Mouse_Intestinal_Tract	Pedunculated_Tubular_Adenoma_of_the_Mouse_Intestinal_Tract	Low Grade Pedunculated Tubular Dysplasia of the Mouse Intestinal Tract|Low Grade Pedunculated Tubular Dysplasia|Low Grade Pedunculated Tubular Dysplasia of the Intestinal Tract	Branching or elongation of crypts with some reduction of interglandular stroma containing cells with low nuclear to cytoplasm ratio. Cell nuclei are elongated, crowded, appear stratified and basally located with regular nuclear membranes, fine chromatin, and inconspicuous nucleoli.  Mucus secretion is usually present.
C22142	High_Grade_Pedunculated_Tubular_Dysplasia_of_the_Mouse_Intestinal_Tract	Pedunculated_Tubular_Adenoma_of_the_Mouse_Intestinal_Tract	High Grade Pedunculated Tubular Dysplasia of the Mouse Intestinal Tract|High Grade Pedunculated Tubular Dysplasia|High Grade Pedunculated Tubular Dysplasia of the Intestinal Tract	There are both architectural and cytologic changes. There is marked reduction of interglandular stroma with complex irregularity of glands.  There is a high nuclear to cytoplasm ratio.  The cell nuclei are large, ovoid to round and are not basally located with marked irregular nuclear membranes, cleared, vesicular, clumped, or densely hyperchromatic chromatin, and large conspicuous nucleoli.  Mucus is typically absent.  Mitotic activity is prominent.
C22143	Pedunculated_Tubulovillous_Adenoma_of_the_Mouse_Intestinal_Tract	Pedunculated_Adenoma_of_the_Mouse_Intestinal_Tract	Pedunculated Tubulovillous Adenoma of the Mouse Intestinal Tract|Pedunculated Tubulovillous Adenoma|Pedunculated Tubulovillous Adenoma of the Intestinal Tract	Containing features of both tubular and villous components.  Each component comprises more than 20% of the tumor
C22144	Low_Grade_Pedunculated_Tubulovillous_Dysplasia_of_the_Mouse_Intestinal_Tract	Pedunculated_Tubulovillous_Adenoma_of_the_Mouse_Intestinal_Tract	Low Grade Pedunculated Tubulovillous Dysplasia of the Mouse Intestinal Tract|Low Grade Pedunculated Tubulovillous Dysplasia|Low Grade Pedunculated Tubulovillous Dysplasia of the Intestinal Tract	Branching or elongation of crypts with some reduction of interglandular stroma containing cells with low nuclear to cytoplasm ratio. Cell nuclei are elongated, crowded, appear stratified and basally located with regular nuclear membranes, fine chromatin, and inconspicuous nucleoli.  Mucus secretion is usually present.
C22145	High_Grade_Pedunculated_Tubulovillous_Dysplasia_of_the_Mouse_Intestinal_Tract	Pedunculated_Tubulovillous_Adenoma_of_the_Mouse_Intestinal_Tract	High Grade Pedunculated Tubulovillous Dysplasia of the Mouse Intestinal Tract|High Grade Pedunculated Tubulovillous Dysplasia|High Grade Pedunculated Tubulovillous Dysplasia of the Intestinal Tract	There are both architectural and cytologic changes. There is marked reduction of interglandular stroma with complex irregularity of glands.  There is a high nuclear to cytoplasm ratio.  The cell nuclei are large, ovoid to round and are not basally located with marked irregular nuclear membranes, cleared, vesicular, clumped, or densely hyperchromatic chromatin, and large conspicuous nucleoli.  Mucus is typically absent.  Mitotic activity is prominent.
C22146	Fibroma_of_the_Mouse_Intestinal_Tract	Benign_Neoplasms_of_the_Mouse_Intestinal_Tract|Mouse_Fibroma	Fibroma of the Mouse Intestinal Tract|Fibroma (MMG0070)|Fibroma of the Intestinal Tract	Circumscribed expansile neoplasm of spindle cells arranged in irregular pattern. There is varying amounts of collagen in the neoplasm.
C22147	Leiomyoma_of_the_Mouse_Intestinal_Tract	Benign_Neoplasms_of_the_Mouse_Intestinal_Tract|Mouse_Leiomyoma	Leiomyoma of the Mouse Intestinal Tract|Leiomyoma|Leiomyoma of the Intestinal Tract	Circumscribed expansile neoplasm of spindle cells arranged in palisading pattern. Neoplasms are positive for myosin.
C22148	Lipoma_of_the_Mouse_Intestinal_Tract	Benign_Neoplasms_of_the_Mouse_Intestinal_Tract|Mouse_Lipoma	Lipoma of the Mouse Intestinal Tract|Lipoma (MMG0073)|Lipoma of the Intestinal Tract	Circumscribed expansile neoplasm of adipose origin
C22149	Hemangioma_of_the_Mouse_Intestinal_Tract	Benign_Neoplasms_of_the_Mouse_Intestinal_Tract|Mouse_Angioma	Hemangioma of the Mouse Intestinal Tract|Hemangioma of the Intestinal Tract|Hemangioma(MMG0074)	Tumor composed of endothelial or spindle cells in vascular patterns. Positive factor VIII
C22150	Neuroendocrine_Adenoma_of_the_Mouse_Intestinal_Tract	Adenoma_of_the_Mouse_Intestinal_Tract	Neuroendocrine Adenoma of the Mouse Intestinal Tract|Neuroendocrine Adenoma of the Intestinal Tract	Neoplasm is isolated to two crypts in size.
C22151	Malignant_Neoplasms_of_the_Mouse_Intestinal_Tract	Neoplasms_of_the_Mouse_Intestinal_Tract	Malignant Neoplasms of the Mouse Intestinal Tract|Malignant Neoplasms of the Intestinal Tract	Tumor is invasive through the basement membrane and may metastasize.  Cells display characteristics of low and/or high grade dysplasia.
C22152	Adenocarcinoma_of_the_Mouse_Intestinal_Tract	Malignant_Neoplasms_of_the_Mouse_Intestinal_Tract|Mouse_Adenocarcinoma	Adenocarcinoma of the Mouse Intestinal Tract|Adenocarcinoma of the Intestinal Tract	Malignant neoplasia of glandular epithelium composed of tubular and or villous structures penetrating beyond the muscularis mucosa.  Tumors display varying degrees of glandular differentiation.
C22153	Tubular_Adenocarcinoma_of_the_Mouse_Intestinal_Tract	Adenocarcinoma_of_the_Mouse_Intestinal_Tract	Tubular Adenocarcinoma of the Mouse Intestinal Tract|Tubular Adenocarcinoma of the Intestinal Tract	Branching tubules surrounded by lamina propria, comprising at least 80% of the tumor. Majority of glands are parallel to the mucosal surface with complex branching patterns.
C22154	Mucinous_Adenocarcinoma_of_the_Mouse_Intestinal_Tract	Adenocarcinoma_of_the_Mouse_Intestinal_Tract	Mucinous Adenocarcinoma of the Mouse Intestinal Tract|Mucinous Adenocarcinoma of the Intestinal Tract	Greater than 50% of the tumor is composed of extracellular mucin.
C22155	Villous_Adenocarcinoma_of_the_Mouse_Intestinal_Tract	Adenocarcinoma_of_the_Mouse_Intestinal_Tract	Villous Adenocarcinoma of the Mouse Intestinal Tract|Villous Adenocarcinoma of the Intestinal Tract	Majority of glands (greater than 75%) are leaf- or finger- like processes of lamina propria covered by dysplastic epithelium.
C22156	Signet_Ring_Cell_Adenocarcinoma_of_the_Mouse_Intestinal_Tract	Adenocarcinoma_of_the_Mouse_Intestinal_Tract	Signet Ring Cell Adenocarcinoma of the Mouse Intestinal Tract|Signet Ring Cell Adenocarcinoma of the Intestinal Tract	Majority of the tumor is composed of (greater than 50%) cells with eccentric nuclei and intracytoplasmic mucin.
C22157	Squamous_Cell_Carcinoma_of_the_Mouse_Intestinal_Tract	Malignant_Neoplasms_of_the_Mouse_Intestinal_Tract|Mouse_Squamous_Cell_Carcinoma	Squamous Cell Carcinoma of the Mouse Intestinal Tract|Squamous Cell Carcinoma of the Intestinal Tract	A malignant epithelial tumor exhibiting squamous differentiation.
C22158	Fibrosarcoma_of_the_Mouse_Intestinal_Tract	Malignant_Neoplasms_of_the_Mouse_Intestinal_Tract|Mouse_Fibrosarcoma	Fibrosarcoma of the Mouse Intestinal Tract|Fibrosarcoma of the Intestinal Tract	Invasive neoplasm of spindle cells arranged in irregular pattern. There is varying amounts of collagen in the neoplasm.
C22159	Leiomyosarcoma_of_the_Mouse_Intestinal_Tract	Malignant_Neoplasms_of_the_Mouse_Intestinal_Tract|Mouse_Leiomyosarcoma	Leiomyosarcoma of the Mouse Intestinal Tract|Leiomyosarcoma of the Intestinal Tract	Invasive neoplasm of spindle cells arranged in palisading pattern. Neoplasms are positive for myosin.
C22160	Lymphoma_of_the_Mouse_Intestinal_Tract	Malignant_Neoplasms_of_the_Mouse_Intestinal_Tract|Mouse_Lymphoma	Lymphoma of the Mouse Intestinal Tract|Lymphoma of the Intestinal Tract	Metastatic or locally originating neoplasm of lymphocytes.
C22161	Hemangiosarcoma_of_the_Mouse_Intestinal_Tract	Malignant_Neoplasms_of_the_Mouse_Intestinal_Tract|Mouse_Angiosarcoma	Hemangiosarcoma of the Mouse Intestinal Tract|Hemangiosarcoma of the Intestinal Tract	Tumor composed of endothelial or spindle cells in vascular patterns with invasion into adjacent tissues. Positive factor VIII
C22162	Liposarcoma_of_the_Mouse_Intestinal_Tract	Malignant_Neoplasms_of_the_Mouse_Intestinal_Tract|Mouse_Liposarcoma	Liposarcoma of the Mouse Intestinal Tract|Liposarcoma of the Intestinal Tract	Large invasive neoplasm of adipose origin
C22163	Neuroendocrine_Cell_Carcinoma_of_the_Mouse_Intestinal_Tract	Malignant_Neoplasms_of_the_Mouse_Intestinal_Tract	Neuroendocrine Cell Carcinoma of the Mouse Intestinal Tract|Neuroendocrine Cell Carcinoma of the Intestinal Tract
C22164	Murine_Tissue_Type	Experimental_Organism_Anatomical_Concepts	Murine Tissue Type|Tissue Type
C22165	Male_Reproductive_System_MMHCC	Reproductive_System_MMHCC	Male Reproductive System (MMHCC)
C22166	Prostate_Gland_MMHCC	Male_Reproductive_System_MMHCC	Prostate Gland (MMHCC)
C22167	Ampullary_Gland_MMHCC	Male_Reproductive_System_MMHCC	Ampullary Gland (MMHCC)
C22168	Bulbourethral_Gland_MMHCC	Male_Reproductive_System_MMHCC	Bulbourethral Gland (MMHCC)
C22169	Anterior_Prostate_Gland_MMHCC	Prostate_Gland_MMHCC	Anterior Prostate Gland (MMHCC)|Coagulating Gland
C22170	Epididymis_MMHCC	Male_Reproductive_System_MMHCC	Epididymis (MMHCC)
C22171	Epididymis_Interstitial_Cell_MMHCC	Epididymis_MMHCC	Epididymis - Interstitial Cell (MMHCC)
C22172	Penis_MMHCC	Male_Reproductive_System_MMHCC	Penis (MMHCC)
C22173	Prepuce_MMHCC	Male_Reproductive_System_MMHCC	Prepuce (MMHCC)
C22174	Prepucial_Gland_MMHCC	Male_Reproductive_System_MMHCC	Prepucial Gland (MMHCC)
C22175	Rete_Testis_MMHCC	Male_Reproductive_System_MMHCC	Rete Testis (MMHCC)
C22176	Scrotum_MMHCC	Male_Reproductive_System_MMHCC	Scrotum (MMHCC)
C22177	Seminal_Vesicles_MMHCC	Male_Reproductive_System_MMHCC	Seminal Vesicles (MMHCC)
C22178	Testis_MMHCC	Male_Reproductive_System_MMHCC	Testis (MMHCC)
C22179	Testis_Germ_Cell_MMHCC	Testis_MMHCC	Testis - Germ Cell (MMHCC)|Sperm Cell
C22180	Testis_Interstitial_Cell_MMHCC	Testis_MMHCC	Testis - Interstitial Cell (MMHCC)
C22181	Testis_Leydig_Cell_MMHCC	Testis_MMHCC	Testis - Leydig Cell (MMHCC)
C22182	Testis_Seminiferous_Tubules_MMHCC	Testis_MMHCC	Testis - Seminiferous Tubules (MMHCC)|Testis - Seminiferous Tubules
C22183	Sertoli_Cells_MMHCC	Testis_Seminiferous_Tubules_MMHCC	Sertoli Cells (MMHCC)|Testis - Seminiferous Tubules - Sertoli Cells
C22184	Tunica_Vaginalis_Testis_MMHCC	Testis_MMHCC	Tunica Vaginalis Testis (MMHCC)
C22185	Vas_Deferens_MMHCC	Testis_MMHCC	Vas Deferens (MMHCC)
C22186	Vesicular_Gland_MMHCC	Testis_MMHCC	Vesicular Gland (MMHCC)
C22187	Experimental_Organism_Diagnoses	root_node	Experimental Organism Diagnosis|Experimental Organism Diagnoses	Any abnormal condition that causes discomfort, dysfunction, or distress to the affected organism. Used broadly to include injuries, disabilities, syndromes, symptoms, deviant behaviors, and atypical variations of structure and function.
C22188	Experimental_Organism_Anatomical_Concepts	root_node	Experimental Organism Anatomical Concept|Experimental Organism Anatomical Concepts
C22189	Genetically_Engineered_Mouse	Laboratory_Animal	Genetically Engineered Mouse|GEM	A mouse that has been genetically modified by introducing new genetic characteristics to it. It often involves the isolation, manipulation and reintroduction of  DNA, usually to express a protein. Serves as an animal model for research purpose.
C22190	Transgene	Gene	Transgene	An engineered gene consisting at least of a regulatory element and a coding sequence; regulatory element and coding sequence can come from different species.
C22191	Mouse_Prostate	Retired_Concepts	Murine Prostate|GENITAL SYSTEM, MALE, PROSTATE|Mouse Prostate|Prostate|Prostate Gland|prostate	A gland in males that surrounds the neck of the BLADDER and the URETHRA. It secretes a substance that liquifies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.
C22192	Ventral_Prostate	Retired_Concepts	Ventral Prostate
C22193	Right_Dorsolateral_Prostate	Retired_Concepts	Right Dorsolateral Prostate
C22194	Right_Coagulating_Gland	Retired_Concepts	Right Coagulating Gland
C22195	Capsule_of_Ventral_Lobe_of_Prostate	Retired_Concepts	Capsule of Ventral Lobe of Prostate
C22196	Parenchyma_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Parenchyma of Right Lobe of Ventral Prostate
C22197	Stroma_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Stroma of Right Lobe of Ventral Prostate
C22198	Capsule_of_Right_Coagulating_Gland_of_Prostate	Retired_Concepts	Capsule of Right Coagulating Gland of Prostate
C22199	Parenchyma_of_Right_Coagulating_Gland_of_Prostate	Retired_Concepts	Parenchyma of Right Coagulating Gland of Prostate
C22200	Stroma_of_Right_Coagulating_Gland_of_Prostate	Retired_Concepts	Stroma of Right Coagulating Gland of Prostate
C22201	Wall_of_Duct_Proper_of_Left_Coagulating_Gland	Retired_Concepts	Wall of Duct Proper of Left Coagulating Gland
C22202	Left_Coagulating_Gland	Retired_Concepts	Left Coagulating Gland
C22203	Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Right Lobe of Ventral Prostate
C22204	Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Left Lobe of Ventral Prostate
C22205	Parenchyma_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Parenchyma of Left Lobe of Ventral Prostate
C22206	Stroma_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Stroma of Left Lobe of Ventral Prostate
C22207	Duct_Tree_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Duct Tree of Right Lobe of Ventral Prostate
C22208	Duct_Tree_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Duct Tree of Left Lobe of Ventral Prostate
C22209	Periductal_Adventitia_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Periductal Adventitia of Right Lobe of Ventral Prostate
C22210	Periductal_Adventitia_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Periductal Adventitia of Left Lobe of Ventral Prostate
C22211	Interductal_Stroma_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Interductal Stroma of Right Lobe of Ventral Prostate
C22212	Interductal_Stroma_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Interductal Stroma of Left Lobe of Ventral Prostate
C22213	Primary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Primary Duct of Right Lobe of Ventral Prostate
C22214	Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Secondary Duct of Right Lobe of Ventral Prostate
C22215	Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Tertiary Duct of Right Lobe of Ventral Prostate
C22216	Primary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Primary Duct of Left Lobe of Ventral Prostate
C22217	Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Secondary Duct of Left Lobe of Ventral Prostate
C22218	Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Tertiary Duct of Left Lobe of Ventral Prostate
C22219	Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Urethral Part of Primary Duct of Right Lobe of Ventral Prostate
C22220	Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Primary Duct Proper of Right Lobe of Ventral Prostate
C22221	Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Primary Duct Proper of Left Lobe of Ventral Prostate
C22222	Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Urethral Part of Primary Duct of Left Lobe of Ventral Prostate
C22223	Left_Dorsolateral_Prostate	Retired_Concepts	Left Dorsolateral Prostate
C22224	Capsule_of_Right_Dorsolateral_Prostate	Retired_Concepts	Capsule of Right Dorsolateral Prostate
C22225	Capsule_of_Left_Dorsolateral_Prostate	Retired_Concepts	Capsule of Left Dorsolateral Prostate
C22226	Parenchyma_of_Right_Dorsolateral_Prostate	Retired_Concepts	Parenchyma of Right Dorsolateral Prostate
C22227	Stroma_of_Right_Dorsolateral_Prostate	Retired_Concepts	Stroma of Right Dorsolateral Prostate
C22228	Stroma_of_Left_Dorsolateral_Prostate	Retired_Concepts	Stroma of Left Dorsolateral Prostate
C22229	Parenchyma_of_Left_Dorsolateral_Prostate	Retired_Concepts	Parenchyma of Left Dorsolateral Prostate
C22230	Right_Coagulating_Gland_Proper	Retired_Concepts	Right Coagulating Gland Proper
C22231	Left_Coagulating_Gland_Proper	Retired_Concepts	Left Coagulating Gland Proper
C22232	Duct_of_Right_Coagulating_Gland	Retired_Concepts	Duct of Right Coagulating Gland
C22233	Duct_of_Left_Coagulating_Gland	Retired_Concepts	Duct of Left Coagulating Gland
C22234	Duct_Tree_of_Right_Dorsolateral_Prostate	Retired_Concepts	Duct Tree of Right Dorsolateral Prostate
C22235	Duct_Tree_of_Left_Dorsolateral_Prostate	Retired_Concepts	Duct Tree of Left Dorsolateral Prostate
C22236	Periductal_Adventitia_of_Right_Dorsolateral_Prostate	Retired_Concepts	Periductal Adventitia of Right Dorsolateral Prostate
C22237	Periductal_Adventitia_of_Left_Dorsolateral_Prostate	Retired_Concepts	Periductal Adventitia of Left Dorsolateral Prostate
C22238	Interductal_Stroma_of_Right_Dorsolateral_Prostate	Retired_Concepts	Interductal Stroma of Right Dorsolateral Prostate
C22239	Interductal_Stroma_of_Left_Dorsolateral_Prostate	Retired_Concepts	Interductal Stroma of Left Dorsolateral Prostate
C22240	Primary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Primary Duct of Right Dorsolateral Prostate
C22241	Secondary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Secondary Duct of Right Dorsolateral Prostate
C22242	Tertiary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Tertiary Duct of Right Dorsolateral Prostate
C22243	Primary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Primary Duct of Left Dorsolateral Prostate
C22244	Secondary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Secondary Duct of Left Dorsolateral Prostate
C22245	Tertiary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Tertiary Duct of Left Dorsolateral Prostate
C22246	Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Urethral Part of Primary Duct of Right Dorsolateral Prostate
C22247	Primary_Duct_Proper_of_Right_Dorsolateral_Prostate	Retired_Concepts	Primary Duct Proper of Right Dorsolateral Prostate
C22248	Primary_Duct_Proper_of_Left_Dorsolateral_Prostate	Retired_Concepts	Primary Duct Proper of Left Dorsolateral Prostate
C22249	Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Urethral Part of Primary Duct of Left Dorsolateral Prostate
C22250	Duct_Tree_of_Right_Coagulating_Gland	Retired_Concepts	Duct Tree of Right Coagulating Gland
C22251	Capsule_of_Left_Coagulating_Gland_of_Prostate	Retired_Concepts	Capsule of Left Coagulating Gland of Prostate
C22252	Parenchyma_of_Left_Coagulating_Gland_of_Prostate	Retired_Concepts	Parenchyma of Left Coagulating Gland of Prostate
C22253	Duct_Tree_of_Left_Coagulating_Gland	Retired_Concepts	Duct Tree of Left Coagulating Gland
C22254	Stroma_of_Left_Coagulating_Gland_of_Prostate	Retired_Concepts	Stroma of Left Coagulating Gland of Prostate
C22255	Primary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Primary Duct of Right Coagulating Gland
C22256	Secondary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Secondary Duct of Right Coagulating Gland
C22257	Tertiary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Tertiary Duct of Right Coagulating Gland
C22258	Periductal_Adventitia_of_Right_Coagulating_Gland	Retired_Concepts	Periductal Adventitia of Right Coagulating Gland
C22259	Interductal_Stroma_of_Right_Coagulating_Gland	Retired_Concepts	Interductal Stroma of Right Coagulating Gland
C22260	Primary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Primary Duct of Left Coagulating Gland
C22261	Secondary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Secondary Duct of Left Coagulating Gland
C22262	Tertiary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Tertiary Duct of Left Coagulating Gland
C22263	Periductal_Adventitia_of_Left_Coagulating_Gland	Retired_Concepts	Periductal Adventitia of Left Coagulating Gland
C22264	Interductal_Stroma_of_Left_Coagulating_Gland	Retired_Concepts	Interductal Stroma of Left Coagulating Gland
C22265	Wall_of_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Wall of Duct of Right Coagulating Gland
C22266	Lumen_of_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Lumen of Duct of Right Coagulating Gland
C22267	Urethral_Part_of_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Urethral Part of Duct of Right Coagulating Gland
C22268	Duct_Proper_of_Right_Coagulating_Gland	Retired_Concepts	Duct Proper of Right Coagulating Gland
C22269	Wall_of_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Wall of Duct of Left Coagulating Gland
C22270	Lumen_of_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Lumen of Duct of Left Coagulating Gland
C22271	Urethral_Part_of_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Urethral Part of Duct of Left Coagulating Gland
C22272	Duct_Proper_of_Left_Coagulating_Gland	Retired_Concepts	Duct Proper of Left Coagulating Gland
C22273	Epithelium_of_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Epithelium of Duct of Right Coagulating Gland
C22274	Muscle_Layer_of_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Muscle Layer of Duct of Right Coagulating Gland
C22275	Adventitia_of_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Adventitia of Duct of Right Coagulating Gland
C22276	Epithelium_of_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Epithelium of Duct of Left Coagulating Gland
C22277	Muscle_Layer_of_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Muscle Layer of Duct of Left Coagulating Gland
C22278	Adventitia_of_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Adventitia of Duct of Left Coagulating Gland
C22279	Epithelium_of_Duct_Proper_of_Left_Coagulating_Gland	Retired_Concepts	Epithelium of Duct Proper of Left Coagulating Gland
C22280	Muscle_Layer_of_Duct_Proper_of_Left_Coagulating_Gland	Retired_Concepts	Muscle Layer of Duct Proper of Left Coagulating Gland
C22281	Periductal_Adventitia_of_Duct_Proper_of_Left_Coagulating_Gland	Retired_Concepts	Periductal Adventitia of Duct Proper of Left Coagulating Gland
C22282	Luminal_Epithelial_Cell_of_Duct_Proper_of_Left_Coagulating_Gland	Retired_Concepts	Luminal Epithelial Cell of Duct Proper of Left Coagulating Gland
C22283	Basal_Epithelial_Cell_of_Duct_Proper_of_Left_Coagulating_Gland	Retired_Concepts	Basal Epithelial Cell of Duct Proper of Left Coagulating Gland
C22284	Neuroendocrine_Cell_of_Duct_Proper_of_Left_Coagulating_Gland	Retired_Concepts	Neuroendocrine Cell of Duct Proper of Left Coagulating Gland
C22285	Basement_Membrane_of_Duct_Proper_of_Left_Coagulating_Gland	Retired_Concepts	Basement Membrane of Duct Proper of Left Coagulating Gland
C22286	Lumen_of_Duct_Proper_of_Left_Coagulating_Gland	Retired_Concepts	Lumen of Duct Proper of Left Coagulating Gland
C22287	Lumen_of_Primary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Lumen of Primary Duct of Left Coagulating Gland
C22288	Lumen_of_Secondary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Lumen of Secondary Duct of Left Coagulating Gland
C22289	Wall_of_Secondary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Wall of Secondary Duct of Left Coagulating Gland
C22290	Lumen_of_Tertiary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Lumen of Tertiary Duct of Left Coagulating Gland
C22291	Wall_of_Tertiary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Wall of Tertiary Duct of Left Coagulating Gland
C22292	Lumen_of_Duct_Proper_of_Right_Coagulating_Gland	Retired_Concepts	Lumen of Duct Proper of Right Coagulating Gland
C22293	Wall_of_Duct_Proper_of_Right_Coagulating_Gland	Retired_Concepts	Wall of Duct Proper of Right Coagulating Gland
C22294	Lumen_of_Primary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Lumen of Primary Duct of Right Coagulating Gland
C22295	Wall_of_Primary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Wall of Primary Duct of Right Coagulating Gland
C22296	Wall_of_Secondary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Wall of Secondary Duct of Right Coagulating Gland
C22297	Lumen_of_Secondary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Lumen of Secondary Duct of Right Coagulating Gland
C22298	Lumen_of_Tertiary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Lumen of Tertiary Duct of Right Coagulating Gland
C22299	Epithelium_of_Duct_Proper_of_Right_Coagulating_Gland	Retired_Concepts	Epithelium of Duct Proper of Right Coagulating Gland
C22300	Muscle_Layer_of_Duct_Proper_of_Right_Coagulating_Gland	Retired_Concepts	Muscle Layer of Duct Proper of Right Coagulating Gland
C22301	Periductal_Adventitia_of_Duct_Proper_of_Right_Coagulating_Gland	Retired_Concepts	Periductal Adventitia of Duct Proper of Right Coagulating Gland
C22302	Wall_of_Primary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Wall of Primary Duct of Left Coagulating Gland
C22303	Wall_of_Tertiary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Wall of Tertiary Duct of Right Coagulating Gland
C22304	Epithelium_of_Secondary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Epithelium of Secondary Duct of Left Coagulating Gland
C22305	Muscle_Layer_of_Secondary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Muscle Layer of Secondary Duct of Left Coagulating Gland
C22306	Periductal_Adventitia_of_Secondary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Periductal Adventitia of Secondary Duct of Left Coagulating Gland
C22307	Epithelium_of_Tertiary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Epithelium of Tertiary Duct of Left Coagulating Gland
C22308	Muscle_Layer_of_Tertiary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Muscle Layer of Tertiary Duct of Left Coagulating Gland
C22309	Periductal_Adventitia_of_Tertiary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Periductal Adventitia of Tertiary Duct of Left Coagulating Gland
C22310	Epithelium_of_Primary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Epithelium of Primary Duct of Right Coagulating Gland
C22311	Muscle_Layer_of_Primary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Muscle Layer of Primary Duct of Right Coagulating Gland
C22312	Periductal_Adventitia_of_Primary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Periductal Adventitia of Primary Duct of Right Coagulating Gland
C22313	Epithelium_of_Secondary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Epithelium of Secondary Duct of Right Coagulating Gland
C22314	Muscle_Layer_of_Secondary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Muscle Layer of Secondary Duct of Right Coagulating Gland
C22315	Periductal_Adventitia_of_Secondary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Periductal Adventitia of Secondary Duct of Right Coagulating Gland
C22316	Epithelium_of_Primary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Epithelium of Primary Duct of Left Coagulating Gland
C22317	Muscle_Layer_of_Primary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Muscle Layer of Primary Duct of Left Coagulating Gland
C22318	Periductal_Adventitia_of_Primary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Periductal Adventitia of Primary Duct of Left Coagulating Gland
C22319	Epithelium_of_Tertiary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Epithelium of Tertiary Duct of Right Coagulating Gland
C22320	Muscle_Layer_of_Tertiary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Muscle Layer of Tertiary Duct of Right Coagulating Gland
C22321	Periductal_Adventitia_of_Tertiary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Periductal Adventitia of Tertiary Duct of Right Coagulating Gland
C22322	Basal_Epithelial_Cell_of_Duct_Proper_of_Right_Coagulating_Gland	Retired_Concepts	Basal Epithelial Cell of Duct Proper of Right Coagulating Gland
C22323	Basement_Membrane_of_Duct_Proper_of_Right_Coagulating_Gland	Retired_Concepts	Basement Membrane of Duct Proper of Right Coagulating Gland
C22324	Luminal_Epithelial_Cell_of_Duct_Proper_of_Right_Coagulating_Gland	Retired_Concepts	Luminal Epithelial Cell of Duct Proper of Right Coagulating Gland
C22325	Neuroendocrine_Cell_of_Duct_Proper_of_Right_Coagulating_Gland	Retired_Concepts	Neuroendocrine Cell of Duct Proper of Right Coagulating Gland
C22326	Basal_Epithelial_Cell_of_Primary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Basal Epithelial Cell of Primary Duct of Left Coagulating Gland
C22327	Basement_Membrane_of_Primary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Basement Membrane of Primary Duct of Left Coagulating Gland
C22328	Luminal_Epithelial_Cell_of_Primary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Luminal Epithelial Cell of Primary Duct of Left Coagulating Gland
C22329	Neuroendocrine_Cell_of_Primary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Neuroendocrine Cell of Primary Duct of Left Coagulating Gland
C22330	Basal_Epithelial_Cell_of_Secondary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Basal Epithelial Cell of Secondary Duct of Left Coagulating Gland
C22331	Basement_Membrane_of_Secondary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Basement Membrane of Secondary Duct of Left Coagulating Gland
C22332	Luminal_Epithelial_Cell_of_Secondary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Luminal Epithelial Cell of Secondary Duct of Left Coagulating Gland
C22333	Neuroendocrine_Cell_of_Secondary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Neuroendocrine Cell of Secondary Duct of Left Coagulating Gland
C22334	Basal_Epithelial_Cell_of_Tertiary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Basal Epithelial Cell of Tertiary Duct of Left Coagulating Gland
C22335	Basement_Membrane_of_Tertiary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Basement Membrane of Tertiary Duct of Left Coagulating Gland
C22336	Luminal_Epithelial_Cell_of_Tertiary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Luminal Epithelial Cell of Tertiary Duct of Left Coagulating Gland
C22337	Neuroendocrine_Cell_of_Tertiary_Duct_of_Left_Coagulating_Gland	Retired_Concepts	Neuroendocrine Cell of Tertiary Duct of Left Coagulating Gland
C22338	Basal_Epithelial_Cell_of_Primary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Basal Epithelial Cell of Primary Duct of Right Coagulating Gland
C22339	Basement_Membrane_of_Primary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Basement Membrane of Primary Duct of Right Coagulating Gland
C22340	Luminal_Epithelial_Cell_of_Primary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Luminal Epithelial Cell of Primary Duct of Right Coagulating Gland
C22341	Neuroendocrine_Cell_of_Primary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Neuroendocrine Cell of Primary Duct of Right Coagulating Gland
C22342	Basement_Membrane_of_Secondary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Basement Membrane of Secondary Duct of Right Coagulating Gland
C22343	Luminal_Epithelial_Cell_of_Secondary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Luminal Epithelial Cell of Secondary Duct of Right Coagulating Gland
C22344	Neuroendocrine_Cell_of_Secondary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Neuroendocrine Cell of Secondary Duct of Right Coagulating Gland
C22345	Basal_Epithelial_Cell_of_Tertiary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Basal Epithelial Cell of Tertiary Duct of Right Coagulating Gland
C22346	Basement_Membrane_of_Tertiary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Basement Membrane of Tertiary Duct of Right Coagulating Gland
C22347	Luminal_Epithelial_Cell_of_Tertiary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Luminal Epithelial Cell of Tertiary Duct of Right Coagulating Gland
C22348	Neuroendocrine_Cell_of_Tertiary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Neuroendocrine Cell of Tertiary Duct of Right Coagulating Gland
C22349	Basal_Epithelial_Cell_of_Secondary_Duct_of_Right_Coagulating_Gland	Retired_Concepts	Basal Epithelial Cell of Secondary Duct of Right Coagulating Gland
C22350	Wall_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate	Retired_Concepts	Wall of Primary Duct Proper of Left Dorsolateral Prostate
C22351	Lumen_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate	Retired_Concepts	Lumen of Primary Duct Proper of Left Dorsolateral Prostate
C22352	Lumen_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Lumen of Urethral Part of Primary Duct of Left Dorsolateral Prostate
C22353	Wall_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Wall of Urethral Part of Primary Duct of Left Dorsolateral Prostate
C22354	Lumen_of_Secondary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Lumen of Secondary Duct of Left Dorsolateral Prostate
C22355	Wall_of_Secondary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Wall of Secondary Duct of Left Dorsolateral Prostate
C22356	Lumen_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Lumen of Tertiary Duct of Left Dorsolateral Prostate
C22357	Wall_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Wall of Tertiary Duct of Left Dorsolateral Prostate
C22358	Lumen_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate	Retired_Concepts	Lumen of Primary Duct Proper of Right Dorsolateral Prostate
C22359	Wall_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate	Retired_Concepts	Wall of Primary Duct Proper of Right Dorsolateral Prostate
C22360	Lumen_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Lumen of Urethral Part of Primary Duct of Right Dorsolateral Prostate
C22361	Wall_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Wall of Urethral Part of Primary Duct of Right Dorsolateral Prostate
C22362	Lumen_of_Secondary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Lumen of Secondary Duct of Right Dorsolateral Prostate
C22363	Wall_of_Secondary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Wall of Secondary Duct of Right Dorsolateral Prostate
C22364	Lumen_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Lumen of Tertiary Duct of Right Dorsolateral Prostate
C22365	Wall_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Wall of Tertiary Duct of Right Dorsolateral Prostate
C22366	Epithelium_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate	Retired_Concepts	Epithelium of Primary Duct Proper of Left Dorsolateral Prostate
C22367	Muscle_Layer_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate	Retired_Concepts	Muscle Layer of Primary Duct Proper of Left Dorsolateral Prostate
C22368	Periductal_Adventitia_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate	Retired_Concepts	Periductal Adventitia of Primary Duct Proper of Left Dorsolateral Prostate
C22369	Epithelium_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Epithelium of Urethral Part of Primary Duct of Left Dorsolateral Prostate
C22370	Muscle_Layer_of_Urethral_Part_of_Primary_Duct_of_Dorsolateral_Prostate	Retired_Concepts	Muscle Layer of Urethral Part of Primary Duct of Dorsolateral Prostate
C22371	Periductal_Adventitia_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Periductal Adventitia of Urethral Part of Primary Duct of Left Dorsolateral Prostate
C22372	Epithelium_of_Secondary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Epithelium of Secondary Duct of Left Dorsolateral Prostate
C22373	Muscle_Layer_of_Secondary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Muscle Layer of Secondary Duct of Left Dorsolateral Prostate
C22374	Periductal_Adventitia_of_Secondary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Periductal Adventitia of Secondary Duct of Left Dorsolateral Prostate
C22375	Epithelium_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Epithelium of Tertiary Duct of Left Dorsolateral Prostate
C22376	Muscle_Layer_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Muscle Layer of Tertiary Duct of Left Dorsolateral Prostate
C22377	Periductal_Adventitia_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Periductal Adventitia of Tertiary Duct of Left Dorsolateral Prostate
C22378	Epithelium_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate	Retired_Concepts	Epithelium of Primary Duct Proper of Right Dorsolateral Prostate
C22379	Muscle_Layer_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate	Retired_Concepts	Muscle Layer of Primary Duct Proper of Right Dorsolateral Prostate
C22380	Periductal_Adventitia_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate	Retired_Concepts	Periductal Adventitia of Primary Duct Proper of Right Dorsolateral Prostate
C22381	Epithelium_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Epithelium of Urethral Part of Primary Duct of Right Dorsolateral Prostate
C22382	Muscle_Layer_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Muscle Layer of Urethral Part of Primary Duct of Right Dorsolateral Prostate
C22383	Periductal_Adventitia_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Periductal Adventitia of Urethral Part of Primary Duct of Right Dorsolateral Prostate
C22384	Epithelium_of_Secondary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Epithelium of Secondary Duct of Right Dorsolateral Prostate
C22385	Muscle_Layer_of_Secondary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Muscle Layer of Secondary Duct of Right Dorsolateral Prostate
C22386	Periductal_Adventitia_of_Secondary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Periductal Adventitia of Secondary Duct of Right Dorsolateral Prostate
C22387	Epithelium_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Epithelium of Tertiary Duct of Right Dorsolateral Prostate
C22388	Muscle_Layer_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Muscle Layer of Tertiary Duct of Right Dorsolateral Prostate
C22389	Basal_Epithelial_Cell_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate	Retired_Concepts	Basal Epithelial Cell of Primary Duct Proper of Left Dorsolateral Prostate
C22390	Luminal_Epithelial_Cell_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate	Retired_Concepts	Luminal Epithelial Cell of Primary Duct Proper of Left Dorsolateral Prostate
C22391	Basement_Membrane_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate	Retired_Concepts	Basement Membrane of Primary Duct Proper of Left Dorsolateral Prostate
C22392	Neuroendocrine_Cell_of_Primary_Duct_Proper_of_Left_Dorsolateral_Prostate	Retired_Concepts	Neuroendocrine Cell of Primary Duct Proper of Left Dorsolateral Prostate
C22393	Basal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Basal Epithelial Cell of Urethral Part of Primary Duct of Left Dorsolateral Prostate
C22394	Basement_Membrane_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Basement Membrane of Urethral Part of Primary Duct of Left Dorsolateral Prostate
C22395	Luminal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Luminal Epithelial Cell of Urethral Part of Primary Duct of Left Dorsolateral Prostate
C22396	Neuroendocrine_Cell_of_Urethral_Part_of_Primary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Neuroendocrine Cell of Urethral Part of Primary Duct of Left Dorsolateral Prostate
C22397	Basal_Epithelial_Cell_of_Secondary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Basal Epithelial Cell of Secondary Duct of Left Dorsolateral Prostate
C22398	Basement_Membrane_of_Secondary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Basement Membrane of Secondary Duct of Left Dorsolateral Prostate
C22399	Luminal_Epithelial_Cell_of_Secondary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Luminal Epithelial Cell of Secondary Duct of Left Dorsolateral Prostate
C22400	Neuroendocrine_Cell_of_Secondary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Neuroendocrine Cell of Secondary Duct of Left Dorsolateral Prostate
C22401	Basal_Epithelial_Cell_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Basal Epithelial Cell of Tertiary Duct of Left Dorsolateral Prostate
C22402	Basement_Membrane_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Basement Membrane of Tertiary Duct of Left Dorsolateral Prostate
C22403	Luminal_Epithelial_Cell_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Luminal Epithelial Cell of Tertiary Duct of Left Dorsolateral Prostate
C22404	Neuroendocrine_Cell_of_Tertiary_Duct_of_Left_Dorsolateral_Prostate	Retired_Concepts	Neuroendocrine Cell of Tertiary Duct of Left Dorsolateral Prostate
C22405	Basal_Epithelial_Cell_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate	Retired_Concepts	Basal Epithelial Cell of Primary Duct Proper of Right Dorsolateral Prostate
C22406	Basement_Membrane_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate	Retired_Concepts	Basement Membrane of Primary Duct Proper of Right Dorsolateral Prostate
C22407	Luminal_Epithelial_Cell_of_Primary_Duct_Proper_of_Right_Dorsolatereal_Prostate	Retired_Concepts	Luminal Epithelial Cell of Primary Duct Proper of Right Dorsolatereal Prostate
C22408	Neuroendocrine_Cell_of_Primary_Duct_Proper_of_Right_Dorsolateral_Prostate	Retired_Concepts	Neuroendocrine Cell of Primary Duct Proper of Right Dorsolateral Prostate
C22409	Basal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Basal Epithelial Cell of Urethral Part of Primary Duct of Right Dorsolateral Prostate
C22410	Basement_Membrane_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Basement Membrane of Urethral Part of Primary Duct of Right Dorsolateral Prostate
C22411	Luminal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Luminal Epithelial Cell of Urethral Part of Primary Duct of Right Dorsolateral Prostate
C22412	Neuroendocrine_Cell_of_Urethral_Part_of_Primary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Neuroendocrine Cell of Urethral Part of Primary Duct of Right Dorsolateral Prostate
C22413	Basal_Epithelial_Cell_of_Secondary_Duct_of_Right_Dorsolatera_Prostate	Retired_Concepts	Basal Epithelial Cell of Secondary Duct of Right Dorsolatera Prostate
C22414	Basement_Membrane_of_Secondary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Basement Membrane of Secondary Duct of Right Dorsolateral Prostate
C22415	Luminal_Epithelial_Cell_of_Secondary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Luminal Epithelial Cell of Secondary Duct of Right Dorsolateral Prostate
C22416	Neuroendocrine_Cell_of_Secondary_Duct_of_Right_Dorsolateral	Retired_Concepts	Neuroendocrine Cell of Secondary Duct of Right Dorsolateral
C22417	Basal_Epithelial_Cell_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Basal Epithelial Cell of Tertiary Duct of Right Dorsolateral Prostate
C22418	Basement_Membrane_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Basement Membrane of Tertiary Duct of Right Dorsolateral Prostate
C22419	Luminal_Epithelial_Cell_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Luminal Epithelial Cell of Tertiary Duct of Right Dorsolateral Prostate
C22420	Neuroendocrine_Cell_of_Tertiary_Duct_of_Right_Dorsolateral_Prostate	Retired_Concepts	Neuroendocrine Cell of Tertiary Duct of Right Dorsolateral Prostate
C22421	Lumen_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Lumen of Primary Duct Proper of Left Lobe of Ventral Prostate
C22422	Wall_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Wall of Primary Duct Proper of Left Lobe of Ventral Prostate
C22423	Lumen_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Lumen of Urethral Part of Primary Duct of Left Lobe of Ventral Prostate
C22424	Wall_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Wall of Urethral Part of Primary Duct of Left Lobe of Ventral Prostate
C22425	Lumen_of_Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Lumen of Secondary Duct of Left Lobe of Ventral Prostate
C22426	Wall_of_Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Wall of Secondary Duct of Left Lobe of Ventral Prostate
C22427	Lumen_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Lumen of Tertiary Duct of Left Lobe of Ventral Prostate
C22428	Wall_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Wall of Tertiary Duct of Left Lobe of Ventral Prostate
C22429	Lumen_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Lumen of Primary Duct Proper of Right Lobe of Ventral Prostate
C22430	Wall_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Wall of Primary Duct Proper of Right Lobe of Ventral Prostate
C22431	Lumen_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Lumen of Urethral Part of Primary Duct of Right Lobe of Ventral Prostate
C22432	Wall_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Wall of Urethral Part of Primary Duct of Right Lobe of Ventral Prostate
C22433	Lumen_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Lumen of Secondary Duct of Right Lobe of Ventral Prostate
C22434	Wall_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Wall of Secondary Duct of Right Lobe of Ventral Prostate
C22435	Lumen_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Lumen of Tertiary Duct of Right Lobe of Ventral Prostate
C22436	Wall_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Wall of Tertiary Duct of Right Lobe of Ventral Prostate
C22437	Epithelium_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Epithelium of Primary Duct Proper of Left Lobe of Ventral Prostate
C22438	Muscle_Layer_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Muscle Layer of Primary Duct Proper of Left Lobe of Ventral Prostate
C22439	Periductal_Adventitia_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Periductal Adventitia of Primary Duct Proper of Left Lobe of Ventral Prostate
C22440	Epithelium_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Epithelium of Urethral Part of Primary Duct of Left Lobe of Ventral Prostate
C22441	Muscle_Layer_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Muscle Layer of Urethral Part of Primary Duct of Left Lobe of Ventral Prostate
C22442	Epithelium_of_Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Epithelium of Secondary Duct of Left Lobe of Ventral Prostate
C22443	Muscle_Layer_of_Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Muscle Layer of Secondary Duct of Left Lobe of Ventral Prostate
C22444	Periductal_Adventitia_of_Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Periductal Adventitia of Secondary Duct of Left Lobe of Ventral Prostate
C22445	Epithelium_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Epithelium of Tertiary Duct of Left Lobe of Ventral Prostate
C22446	Muscle_Layer_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Muscle Layer of Tertiary Duct of Left Lobe of Ventral Prostate
C22447	Periductal_Adventitia_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Periductal Adventitia of Tertiary Duct of Left Lobe of Ventral Prostate
C22448	Epithelium_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Epithelium of Primary Duct Proper of Right Lobe of Ventral Prostate
C22449	Muscle_Layer_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Muscle Layer of Primary Duct Proper of Right Lobe of Ventral Prostate
C22450	Periductal_Adventitia_of_Primary_Duct_Proper_of_Right_Lobe_of_Venral_Prostate	Retired_Concepts	Periductal Adventitia of Primary Duct Proper of Right Lobe of Venral Prostate
C22451	Epithelium_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Epithelium of Urethral Part of Primary Duct of Right Lobe of Ventral Prostate
C22452	Muscle_Layer_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Muscle Layer of Urethral Part of Primary Duct of Right Lobe of Ventral Prostate
C22453	Periductal_Adventitia_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Periductal Adventitia of Urethral Part of Primary Duct of Right Lobe of Ventral Prostate
C22454	Epithelium_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Epithelium of Secondary Duct of Right Lobe of Ventral Prostate
C22455	Muscle_Layer_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Muscle Layer of Secondary Duct of Right Lobe of Ventral Prostate
C22456	Periductal_Adventitia_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Periductal Adventitia of Secondary Duct of Right Lobe of Ventral Prostate
C22457	Epithelium_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Epithelium of Tertiary Duct of Right Lobe of Ventral Prostate
C22458	Muscle_Layer_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Muscle Layer of Tertiary Duct of Right Lobe of Ventral Prostate
C22459	Basal_Epithelial_Cell_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Basal Epithelial Cell of Primary Duct Proper of Left Lobe of Ventral Prostate
C22460	Basement_Membrane_of_Primary_Duct_Proper_of_Left_Lobe_of_Dorsolateral_Prostate	Retired_Concepts	Basement Membrane of Primary Duct Proper of Left Lobe of Dorsolateral Prostate
C22461	Luminal_Epithelial_Cell_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Luminal Epithelial Cell of Primary Duct Proper of Left Lobe of Ventral Prostate
C22462	Neuroendocrine_Cell_of_Primary_Duct_Proper_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Neuroendocrine Cell of Primary Duct Proper of Left Lobe of Ventral Prostate
C22463	Basal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Basal Epithelial Cell of Urethral Part of Primary Duct of Left Lobe of Ventral Prostate
C22464	Basement_Membrane_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Basement Membrane of Urethral Part of Primary Duct of Left Lobe of Ventral Prostate
C22465	Luminal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Luminal Epithelial Cell of Urethral Part of Primary Duct of Left Lobe of Ventral Prostate
C22466	Neuroendocrine_Cell_of_Urethral_Part_of_Primary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Neuroendocrine Cell of Urethral Part of Primary Duct of Left Lobe of Ventral Prostate
C22467	Basal_Epithelial_Cell_of_Secondary_Duct_of_Left_Lobe_of_Venral_Prostate	Retired_Concepts	Basal Epithelial Cell of Secondary Duct of Left Lobe of Venral Prostate
C22468	Luminal_Epithelial_Cell_of_Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Luminal Epithelial Cell of Secondary Duct of Left Lobe of Ventral Prostate
C22469	Neuroendocrine_Cell_of_Secondary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Neuroendocrine Cell of Secondary Duct of Left Lobe of Ventral Prostate
C22470	Basal_Epithelial_Cell_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Basal Epithelial Cell of Tertiary Duct of Left Lobe of Ventral Prostate
C22471	Basement_Membrane_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Basement Membrane of Tertiary Duct of Left Lobe of Ventral Prostate
C22472	Luminal_Epithelial_Cell_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Luminal Epithelial Cell of Tertiary Duct of Left Lobe of Ventral Prostate
C22473	Neuroendocrine_Cell_of_Tertiary_Duct_of_Left_Lobe_of_Ventral_Prostate	Retired_Concepts	Neuroendocrine Cell of Tertiary Duct of Left Lobe of Ventral Prostate
C22474	Basal_Epithelial_Cell_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Basal Epithelial Cell of Primary Duct Proper of Right Lobe of Ventral Prostate
C22475	Basement_Membrane_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Basement Membrane of Primary Duct Proper of Right Lobe of Ventral Prostate
C22476	Luminal_Epithelial_Cell_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Luminal Epithelial Cell of Primary Duct Proper of Right Lobe of Ventral Prostate
C22477	Neuroendocrine_Cell_of_Primary_Duct_Proper_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Neuroendocrine Cell of Primary Duct Proper of Right Lobe of Ventral Prostate
C22478	Basal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Basal Epithelial Cell of Urethral Part of Primary Duct of Right Lobe of Ventral Prostate
C22479	Luminal_Epithelial_Cell_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Luminal Epithelial Cell of Urethral Part of Primary Duct of Right Lobe of Ventral Prostate
C22480	Neuroendocrine_Cell_of_Urethral_Part_of_Primary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Neuroendocrine Cell of Urethral Part of Primary Duct of Right Lobe of Ventral Prostate
C22481	Basal_Epithelial_Cell_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Basal Epithelial Cell of Secondary Duct of Right Lobe of Ventral Prostate
C22482	Basement_Membrane_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Basement Membrane of Secondary Duct of Right Lobe of Ventral Prostate
C22483	Luminal_Epithelial_Cell_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Luminal Epithelial Cell of Secondary Duct of Right Lobe of Ventral Prostate
C22484	Neuroendocrine_Cell_of_Secondary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Neuroendocrine Cell of Secondary Duct of Right Lobe of Ventral Prostate
C22485	Basal_Epithelial_Cell_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Basal Epithelial Cell of Tertiary Duct of Right Lobe of Ventral Prostate
C22486	Periductal_Adventitia_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Periductal Adventitia of Tertiary Duct of Right Lobe of Ventral Prostate
C22487	Luminal_Epithelial_Cell_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Luminal Epithelial Cell of Tertiary Duct of Right Lobe of Ventral Prostate
C22488	Neuroendocrine_Cell_of_Tertiary_Duct_of_Right_Lobe_of_Ventral_Prostate	Retired_Concepts	Neuroendocrine Cell of Tertiary Duct of Right Lobe of Ventral Prostate
C22489	Organism_Modification	Techniques	Organism Modification	Techniques used for deliberately altering the genetic material of an organism in order to make them capable of making new substances or performing new or different functions. (NCI2005)
C22490	Tumor_Cell_Graft	Organism_Modification	Tumor Cell Graft
C22491	Knock-out	Organism_Modification	Knock-out|Knockout	Inactivation of specific genes by homologous recombination. Knockouts are often created in laboratory organisms such as yeast or mice so that scientists can study the knockout organism as a model for a particular disease. (NCI2005)
C22492	Knock-in	Organism_Modification	Knock-in Mouse|Knock-in	Replacement of a gene by an altered version of the same gene using homologous recombination resulting in a gain of function. One example of a knock-in is deletion of a coding sequence of a gene in a mouse and then replacing it with human coding sequences. (NCI2005)
C22493	Radiation-Induced_Change	Organism_Modification	Radiation-Induced Change|Radiation	Techniques used for altering the genetic material of an organism by exposure to ionizing radiation. (NCI2005)
C22494	Chemical-Induced_Change	Organism_Modification	Chemical-Induced Change|Chemical
C22495	Retrovirus	Organism_Modification	Retrovirus Insertion Modification|Retrovirus	Organism modification caused by change in its genetic material brought about by retrovirus. The retrovirus constructs a DNA version of its genes using a special enzyme called reverse transcriptase and this DNA then becomes part of the cell's genetic material.(NCI2005)
C22496	Rat_Transgene	Organism_Modification	Rat Transgene	Modification of a rat by transgenic techniques.
C22497	Cardiovascular_System_MMHCC	Murine_Tissue_Type	Cardiovascular System (MMHCC)
C22498	Heart_MMHCC	Cardiovascular_System_MMHCC	Heart (MMHCC)
C22499	Blood_Vessel_MMHCC	Cardiovascular_System_MMHCC	Blood Vessel (MMHCC)
C22500	Digestive_System_MMHCC	Murine_Tissue_Type	Digestive System (MMHCC)
C22501	Oral_Cavity_MMHCC	Digestive_System_MMHCC	Oral Cavity (MMHCC)
C22502	Teeth_MMHCC	Digestive_System_MMHCC	Teeth (MMHCC)
C22503	Salivary_Gland_MMHCC	Digestive_System_MMHCC	Salivary Gland (MMHCC)
C22504	Salivary_Gland_Parotid_MMHCC	Salivary_Gland_MMHCC	Salivary Gland - Parotid (MMHCC)|Parotid|Parotid Gland
C22505	Salivary_Gland_Sublingual_MMHCC	Salivary_Gland_MMHCC	Salivary Gland - Sublingual (MMHCC)|Sublingual Gland
C22506	Salivary_Gland_Submandibular_MMHCC	Salivary_Gland_MMHCC	Salivary Gland - Submandibular (MMHCC)|Submandibular Gland
C22507	Pharynx_MMHCC	Digestive_System_MMHCC	Pharynx (MMHCC)
C22508	Tongue_MMHCC	Digestive_System_MMHCC	Tongue (MMHCC)
C22509	Esophagus_MMHCC	Digestive_System_MMHCC	Esophagus (MMHCC)
C22510	Gastrointestinal_Tract_MMHCC	Digestive_System_MMHCC	Gastrointestinal Tract (MMHCC)
C22511	Stomach_MMHCC	Gastrointestinal_Tract_MMHCC	Stomach (MMHCC)
C22512	Forestomach_MMHCC	Digestive_System_MMHCC	Forestomach (MMHCC)
C22513	Stomach_glandular_MMHCC	Stomach_MMHCC	Stomach (glandular) (MMHCC)|Glandular Stomach
C22514	Stomach_glandular_Pyloric_Antrum_MMHCC	Stomach_glandular_MMHCC	Stomach (glandular) - Pyloric Antrum (MMHCC)|Pyloric Antrum
C22515	Liver_MMHCC	Digestive_System_MMHCC	Liver (MMHCC)
C22516	Liver_fetal_MMHCC	Liver_MMHCC	Liver (fetal) (MMHCC)
C22517	Liver_Hepatocyte_MMHCC	Liver_MMHCC	Liver - Hepatocyte (MMHCC)|Hepatocyte
C22518	Liver_Sinusoid_MMHCC	Liver_MMHCC	Liver - Sinusoid (MMHCC)
C22519	Liver_Sinusoid_Ito_Cell_MMHCC	Liver_Sinusoid_MMHCC	Liver - Sinusoid - Ito Cell (MMHCC)
C22520	Gallbladder_MMHCC	Biliary_Tract_MMHCC	Gallbladder (MMHCC)|Gallbladder
C22521	Intestine_MMHCC	Gastrointestinal_Tract_MMHCC	Intestine (MMHCC)
C22522	Intestine_Small_Intestine_MMHCC	Intestine_MMHCC	Intestine - Small Intestine (MMHCC)|Small Intestine
C22523	Intestine_Small_Intestine_Duodenum_MMHCC	Intestine_Small_Intestine_MMHCC	Intestine - Small Intestine - Duodenum (MMHCC)|Duodenum
C22524	Intestine_Small_Intestine_Jejunum_MMHCC	Intestine_Small_Intestine_MMHCC	Intestine - Small Intestine - Jejunum (MMHCC)|Jejunum
C22525	Intestine_Small_Intestine_Ileum_MMHCC	Intestine_Small_Intestine_MMHCC	Intestine - Small Intestine - Ileum (MMHCC)|Ileum
C22526	Intestine_Large_Intestine_MMHCC	Intestine_MMHCC	Intestine - Large Intestine (MMHCC)|Large Intestine
C22527	Intestine_Large_Intestine_Cecum_MMHCC	Intestine_Large_Intestine_MMHCC	Intestine - Large Intestine - Cecum (MMHCC)|Cecum
C22528	Intestine_Large_Intestine_Colon_MMHCC	Intestine_Large_Intestine_MMHCC	Intestine - Large Intestine - Colon (MMHCC)|Colon
C22529	Large_Intestine_Colon_Proximal_MMHCC	Intestine_Large_Intestine_Colon_MMHCC	Large Intestine - Colon - Proximal (MMHCC)
C22530	Large_Intestine_Colon_Medial_MMHCC	Intestine_Large_Intestine_Colon_MMHCC	Large Intestine - Colon - Medial (MMHCC)
C22531	Large_Intestine_Colon_Distal_MMHCC	Intestine_Large_Intestine_Colon_MMHCC	Large Intestine - Colon - Distal (MMHCC)
C22532	Intestine_Large_Intestine_Rectum_MMHCC	Intestine_Large_Intestine_MMHCC	Intestine - Large Intestine - Rectum (MMHCC)|Rectum
C22533	Intestine_Large_Intestine_Anus_MMHCC	Intestine_Large_Intestine_MMHCC	Intestine - Large Intestine - Anus (MMHCC)|Anus
C22534	Integument_System_MMHCC	Murine_Tissue_Type	Integument System (MMHCC)
C22535	Skin_MMHCC	Integument_System_MMHCC	Skin (MMHCC)
C22536	Skin_Anogenital_Region_MMHCC	Skin_MMHCC	Skin - Anogenital Region (MMHCC)
C22537	Skin_Dermis_MMHCC	Skin_MMHCC	Skin - Dermis (MMHCC)|Dermis
C22538	Skin_Dorsal_Region_MMHCC	Skin_MMHCC	Skin - Dorsal Region (MMHCC)
C22539	Skin_Epidermis_MMHCC	Skin_MMHCC	Skin - Epidermis (MMHCC)|Epidermis
C22540	Skin_Epidermis_Basal_Cell_MMHCC	Skin_Epidermis_MMHCC	Skin - Epidermis - Basal Cell (MMHCC)|Basal Cell
C22541	Skin_Epidermis_Hair_Matrix_Cell_MMHCC	Skin_Epidermis_MMHCC	Skin - Epidermis - Hair Matrix Cell (MMHCC)|Hair Matrix Cell
C22542	Skin_Epidermis_Keratinocyte_MMHCC	Skin_Epidermis_MMHCC	Skin - Epidermis - Keratinocyte (MMHCC)|Keratinocyte
C22543	Skin_Melanocyte_MMHCC	Skin_MMHCC	Skin - Melanocyte (MMHCC)|Melanocyte
C22544	Skin_Hair_Follicle_MMHCC	Skin_MMHCC	Skin - Hair Follicle (MMHCC)|Hair Follicle
C22545	Skin_Gland_MMHCC	Skin_MMHCC	Skin Gland (MMHCC)
C22546	Skin_Gland_Sebaceous_Gland_MMHCC	Skin_Gland_MMHCC	Skin Gland - Sebaceous Gland (MMHCC)|Sebaceous Gland
C22547	Skin_Gland_Sweat_Gland_MMHCC	Skin_Gland_MMHCC	Skin Gland - Sweat Gland (MMHCC)|Sweat Gland
C22548	Skin_Gland_Mucous_Gland_MMHCC	Skin_Gland_MMHCC	Skin Gland - Mucous Gland (MMHCC)
C22549	Mammary_Gland_MMHCC	Integument_System_MMHCC	Mammary Gland (MMHCC)
C22550	Mammary_Fat_Pad_MMHCC	Integument_System_MMHCC	Mammary Fat Pad (MMHCC)
C22551	Lymphohematopoietic_System_MMHCC	Murine_Tissue_Type	Lymphohematopoietic System (MMHCC)
C22552	Bone_Marrow_MMHCC	Lymphohematopoietic_System_MMHCC	Bone Marrow (MMHCC)
C22553	Thymus_MMHCC	Lymphohematopoietic_System_MMHCC	Thymus (MMHCC)
C22554	Thymus_Cortex_MMHCC	Thymus_MMHCC	Thymus - Cortex (MMHCC)
C22555	Thymus_Medulla_MMHCC	Thymus_MMHCC	Thymus - Medulla (MMHCC)
C22556	Spleen_MMHCC	Lymphohematopoietic_System_MMHCC	Spleen (MMHCC)
C22557	Spleen_Red_Pulp_MMHCC	Spleen_MMHCC	Spleen - Red Pulp (MMHCC)|Red Pulp
C22558	Spleen_White_Pulp_MMHCC	Spleen_MMHCC	Spleen - White Pulp (MMHCC)|White Pulp
C22559	Blood_MMHCC	Lymphohematopoietic_System_MMHCC	Blood (MMHCC)
C22560	Blood_fetal_MMHCC	Lymphohematopoietic_System_MMHCC	Blood (fetal) (MMHCC)|Fetal Blood
C22561	Lymph_Node_MMHCC	Lymphohematopoietic_System_MMHCC	Lymph Node (MMHCC)
C22562	Peyers_Patch_MMHCC	Lymphohematopoietic_System_MMHCC	Peyers Patch (MMHCC)
C22563	Stem_Cell_MMHCC	Lymphohematopoietic_System_MMHCC	Stem Cell (MMHCC)
C22564	Myeloerythroid_Progenitor_MMHCC	Lymphohematopoietic_System_MMHCC	Myeloerythroid Progenitor (MMHCC)
C22565	Erythroblast_MMHCC	Lymphohematopoietic_System_MMHCC	Erythroblast (MMHCC)
C22566	Erythrocyte_RBC_MMHCC	Lymphohematopoietic_System_MMHCC	Erythrocyte (RBC) (MMHCC)|Erythrocyte|RBC
C22567	Megakaryocyte_MMHCC	Lymphohematopoietic_System_MMHCC	Megakaryocyte (MMHCC)
C22568	Platelet_MMHCC	Lymphohematopoietic_System_MMHCC	Platelet (MMHCC)
C22569	Leukoblast_MMHCC	Lymphohematopoietic_System_MMHCC	Leukoblast (MMHCC)
C22570	Leukocyte_WBC_MMHCC	Lymphohematopoietic_System_MMHCC	Leukocyte (WBC) (MMHCC)|Leukocyte|WBC
C22571	Leukocyte_Lymphoblast_MMHCC	Leukocyte_WBC_MMHCC	Leukocyte - Lymphoblast (MMHCC)|Lymphoblast
C22572	Leukocyte_Lymphocyte_MMHCC	Leukocyte_WBC_MMHCC	Leukocyte - Lymphocyte (MMHCC)|Lymphocyte
C22573	Leukocyte_Lymphocyte_Immature_B-Lymphocyte_MMHCC	Leukocyte_Lymphocyte_MMHCC	Leukocyte - Lymphocyte - Immature B-Lymphocyte (MMHCC)|Immature B-Lymphocyte
C22574	Leukocyte_Lymphocyte_Pre-B-Lymphocyte_MMHCC	Leukocyte_Lymphocyte_MMHCC	Leukocyte - Lymphocyte - Pre-B-Lymphocyte (MMHCC)|Pre B-Lymphocyte|Pre-B-Lymphocyte
C22575	Leukocyte_Lymphocyte_Pro-B-Lymphocyte_MMHCC	Leukocyte_Lymphocyte_MMHCC	Leukocyte - Lymphocyte - Pro-B-Lymphocyte (MMHCC)|Pro B-Lymphocyte|Pro-B-Lymphocyte
C22576	Leukocyte_Lymphocyte_B-Lymphocyte_MMHCC	Leukocyte_Lymphocyte_MMHCC	Leukocyte - Lymphocyte - B-Lymphocyte (MMHCC)|B-Lymphocyte
C22577	Leukocyte_Lymphocyte_B-Lymphocyte_Plasma_Cell_MMHCC	Leukocyte_Lymphocyte_B-Lymphocyte_MMHCC	Leukocyte - Lymphocyte - B-Lymphocyte - Plasma Cell (MMHCC)|Plasma Cell
C22578	Leukocyte_Lymphocyte_B-Lymphocyte_Follicular_Center_Cell_MMHCC	Leukocyte_Lymphocyte_B-Lymphocyte_MMHCC	Leukocyte - Lymphocyte - B-Lymphocyte - Follicular Center Cell (MMHCC)|Follicular Center Cell
C22579	Leukocyte_Lymphocyte_Immature_T-Lymphocyte_MMHCC	Leukocyte_Lymphocyte_MMHCC	Leukocyte - Lymphocyte - Immature T-Lymphocyte (MMHCC)|Immature T-Lymphocyte
C22580	Leukocyte_Lymphocyte_Pre-T-Lymphocyte_MMHCC	Leukocyte_Lymphocyte_MMHCC	Leukocyte - Lymphocyte - Pre-T-Lymphocyte (MMHCC)|Pre-T-Lymphocyte
C22581	Leukocyte_Lymphocyte_Pro-T-Lymphocyte_MMHCC	Leukocyte_Lymphocyte_MMHCC	Leukocyte - Lymphocyte - Pro-T-Lymphocyte (MMHCC)|Pro T-Lymphocyte|Pro-T-Lymphocyte
C22582	Leukocyte_Lymphocyte_T-Lymphocyte_MMHCC	Leukocyte_Lymphocyte_MMHCC	Leukocyte - Lymphocyte - T-Lymphocyte (MMHCC)|T-Lymphocyte
C22583	Leukocyte_Lymphocyte_Thymocyte_MMHCC	Leukocyte_Lymphocyte_MMHCC	Leukocyte - Lymphocyte - Thymocyte (MMHCC)|Thymocyte
C22584	Leukocyte_Monoblast_MMHCC	Leukocyte_WBC_MMHCC	Leukocyte - Monoblast (MMHCC)|Monoblast
C22585	Leukocyte_Promonocyte_MMHCC	Leukocyte_WBC_MMHCC	Leukocyte - Promonocyte (MMHCC)|Promonocyte
C22586	Leukocyte_Monocyte_MMHCC	Leukocyte_WBC_MMHCC	Leukocyte - Monocyte (MMHCC)|Monocyte
C22587	Leukocyte_Monocyte_Macrophage_MMHCC	Leukocyte_Monocyte_MMHCC	Leukocyte - Monocyte - Macrophage (MMHCC)|Macrophage
C22588	Leukocyte_Monocyte_Macrophage_Histiocyte_MMHCC	Leukocyte_Monocyte_Macrophage_MMHCC	Leukocyte - Monocyte - Macrophage - Histiocyte (MMHCC)|Histiocyte
C22589	Leukocyte_Myeloblast_MMHCC	Leukocyte_WBC_MMHCC	Leukocyte - Myeloblast (MMHCC)|Myeloblast
C22590	Leukocyte_Myelocyte_Granulocyte_MMHCC	Leukocyte_WBC_MMHCC	Leukocyte - Myelocyte (Granulocyte) (MMHCC)|Granulocyte
C22591	Leukocyte_Myelocyte_Granulocyte_Basophil_MMHCC	Leukocyte_Myelocyte_Granulocyte_MMHCC	Leukocyte - Myelocyte (Granulocyte) - Basophil (MMHCC)|Basophil
C22592	Leukocyte_Myelocyte_Granulocyte_Eosinophil_MMHCC	Leukocyte_Myelocyte_Granulocyte_MMHCC	Leukocyte - Myelocyte (Granulocyte) - Eosinophil (MMHCC)|Eosinophil
C22593	Leukocyte_Myelocyte_Granulocyte_Neutrophil_MMHCC	Leukocyte_Myelocyte_Granulocyte_MMHCC	Leukocyte - Myelocyte (Granulocyte) - Neutrophil (MMHCC)|Neutrophil
C22594	Leukocyte_Myelocyte_Granulocyte_Basophil_Mast_Cell_MMHCC	Leukocyte_Myelocyte_Granulocyte_Basophil_MMHCC	Leukocyte - Myelocyte (Granulocyte) - Basophil - Mast Cell (MMHCC)|Mast Cell
C22595	Leukocyte_Natural_Killer_Cell_MMHCC	Leukocyte_WBC_MMHCC	Leukocyte - Natural Killer Cell (MMHCC)|NK Cell|Natural Killer Cell
C22596	Dendritic_Cell_MMHCC	Lymphohematopoietic_System_MMHCC	Dendritic Cell (MMHCC)
C22597	Respiratory_System_MMHCC	Murine_Tissue_Type	Respiratory System (MMHCC)
C22598	Larynx_MMHCC	Respiratory_System_MMHCC	Larynx (MMHCC)
C22599	Trachea_MMHCC	Respiratory_System_MMHCC	Trachea (MMHCC)
C22600	Lung_MMHCC	Respiratory_System_MMHCC	Lung (MMHCC)
C22601	Lung_Alveolus_MMHCC	Lung_MMHCC	Lung - Alveolus (MMHCC)|Alveolus
C22602	Lung_Bronchiole_MMHCC	Lung_MMHCC	Lung - Bronchiole (MMHCC)|Bronchiole
C22603	Lung_Clara_Cell_MMHCC	Lung_Alveolus_MMHCC	Lung - Clara Cell (MMHCC)|Clara Cell
C22604	Nervous_System_MMHCC	Murine_Tissue_Type	Nervous System (MMHCC)
C22605	CNS_MMHCC	Nervous_System_MMHCC	CNS (MMHCC)|Central Nervous System
C22606	CNS_Brain_MMHCC	CNS_MMHCC	CNS - Brain (MMHCC)|Brain
C22607	CNS_Brain_Astrocyte_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Astrocyte (MMHCC)|Astrocyte
C22608	CNS_Brain_Brain_Stem_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Brain Stem (MMHCC)|Brain Stem
C22609	CNS_Brain_Cerebellum_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Cerebellum (MMHCC)|Cerebellum
C22610	CNS_Brain_Cerebrum_Cortex_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Cerebrum/Cortex (MMHCC)|Cerebrum
C22611	CNS_Brain_Choroid_Plexus_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Choroid Plexus (MMHCC)|Choroid Plexus
C22612	CNS_Brain_Ependyma_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Ependyma (MMHCC)|Ependyma
C22613	CNS_Brain_Glial_Cell_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Glial Cell (MMHCC)|Glial Cell
C22614	CNS_Brain_Hindbrain_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Hindbrain (MMHCC)|Hindbrain
C22615	CNS_Brain_Hippocampus_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Hippocampus (MMHCC)|Hippocampus
C22616	CNS_Brain_Hypothalamus_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Hypothalamus (MMHCC)|Hypothalamus
C22617	CNS_Brain_Meninges_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Meninges (MMHCC)|Meninges
C22618	CNS_Brain_Neuron_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Neuron (MMHCC)|Neuron
C22619	CNS_Brain_Olfactory_Bulb_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Olfactory Bulb (MMHCC)|Olfactory Bulb
C22620	CNS_Brain_Oligodendroglial_Cell_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Oligodendroglial Cell (MMHCC)|Oligodendroglial Cell
C22621	CNS_Brain_Optic_Chiasma_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Optic Chiasma (MMHCC)|Optic Chiasma
C22622	CNS_Brain_Striatum_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Striatum (MMHCC)|Striatum
C22623	CNS_Brain_Thalamus_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Thalamus (MMHCC)|Thalamus
C22624	CNS_Brain_Undifferentiated_Cell_MMHCC	CNS_Brain_MMHCC	CNS - Brain - Undifferentiated Cell (MMHCC)|Undifferentiated Brain Cell
C22625	CNS_Spinal_Cord_MMHCC	CNS_MMHCC	CNS - Spinal Cord (MMHCC)|Spinal Cord
C22626	CNS_Spinal_Cord_Neuron_MMHCC	CNS_Spinal_Cord_MMHCC	CNS - Spinal Cord - Neuron (MMHCC)|Spinal Cord Neuron	Neuron is also used as a concept under brain in this hierarchy.  Both Brain and Spinal Cord neurons are CNS neurons.
C22627	CNS_Spinal_Cord_Neuron_Ganglion_MMHCC	CNS_Spinal_Cord_Neuron_MMHCC	CNS - Spinal Cord - Neuron - Ganglion (MMHCC)
C22628	Nerve_MMHCC	PNS_MMHCC	Nerve (MMHCC)
C22629	Nerve_Raphe_Nuclei_MMHCC	Nerve_MMHCC	Nerve - Raphe Nuclei (MMHCC)|Raphe Nuclei
C22630	Neuroblast_MMHCC	Nervous_System_MMHCC	Neuroblast (MMHCC)
C22631	PNS_MMHCC	Nervous_System_MMHCC	PNS (MMHCC)|Peripheral Nervous System
C22632	PNS_Schwann_Cell_MMHCC	PNS_MMHCC	PNS - Schwann Cell (MMHCC)|Schwann Cell
C22633	Mouse_Reproductive_System	Retired_Concepts	Murine Reproductive System|Mouse Reproductive System|Reproductive System|reproductive system
C22634	Endocrine_Gland_System_MMHCC	Murine_Tissue_Type	Endocrine Gland System (MMHCC)
C22635	Adrenal_Gland_MMHCC	Endocrine_Gland_System_MMHCC	Adrenal Gland (MMHCC)
C22636	Adrenal_Gland_Cortex_MMHCC	Adrenal_Gland_MMHCC	Adrenal Gland - Cortex (MMHCC)|Adrenal Cortex
C22637	Adrenal_Gland_Medulla_MMHCC	Adrenal_Gland_MMHCC	Adrenal Gland - Medulla (MMHCC)|Adrenal Medulla
C22638	Adrenal_Gland_Subcapsular_Cell_MMHCC	Adrenal_Gland_MMHCC	Adrenal Gland - Subcapsular Cell (MMHCC)|Adrenal Subcapsular Cell
C22639	Endocrine_Pancreas_MMHCC	Endocrine_Gland_System_MMHCC|Pancreas_MMHCC	Endocrine Pancreas (MMHCC)
C22640	Endocrine_Pancreas_Islet_of_Langerhans_MMHCC	Endocrine_Pancreas_MMHCC	Endocrine Pancreas - Islet of Langerhans (MMHCC)|Islet of Langerhans
C22641	Endocrine_Pancreas_Islet_of_Langerhans_Alpha_Cell_MMHCC	Endocrine_Pancreas_Islet_of_Langerhans_MMHCC	Endocrine Pancreas - Islet of Langerhans - Alpha Cell (MMHCC)|Alpha Cell of Islet|Pancreatic Alpha Cell
C22642	Endocrine_Pancreas_Islet_Cell_of_Langerhans_Beta_Cell_MMHCC	Endocrine_Pancreas_Islet_of_Langerhans_MMHCC	Endocrine Pancreas - Islet Cell of Langerhans - Beta Cell (MMHCC)|Beta Cell of Islet|Pancreatic Beta Cell
C22643	Exocrine_Pancreas_Acinar_Cell_MMHCC	Exocrine_Pancreas_MMHCC	Exocrine Pancreas - Acinar Cell (MMHCC)|Acinar Cell
C22644	Parathyroid_Gland_MMHCC	Endocrine_Gland_System_MMHCC	Parathyroid Gland (MMHCC)|Parathyroid
C22645	Pineal_Gland_MMHCC	Endocrine_Gland_System_MMHCC	Pineal Gland (MMHCC)|Pineal
C22646	Pituitary_Gland_MMHCC	Endocrine_Gland_System_MMHCC	Pituitary Gland (MMHCC)|Pituitary
C22647	Pituitary_Gland_Pars_Anterior_MMHCC	Pituitary_Gland_MMHCC	Pituitary Gland - Pars Anterior (MMHCC)
C22648	Pituitary_Gland_Pars_Intermedia_MMHCC	Pituitary_Gland_MMHCC	Pituitary Gland - Pars Intermedia (MMHCC)
C22649	Pituitary_Gland_Pars_Distalis_MMHCC	Pituitary_Gland_MMHCC	Pituitary Gland - Pars Distalis (MMHCC)
C22650	Thyroid_Gland_MMHCC	Endocrine_Gland_System_MMHCC	Thyroid Gland (MMHCC)|Thyroid
C22651	Thyroid_Gland_Parafollicular_Cell_MMHCC	Thyroid_Gland_MMHCC	Thyroid Gland - Parafollicular Cell (MMHCC)|Thyroid Parafollicular Cell
C22652	Thyroid_Gland_Follicular_Cell_MMHCC	Thyroid_Gland_MMHCC	Thyroid Gland - Follicular Cell (MMHCC)|Thyroid Follicular Cell
C22653	Female_Reproductive_System_MMHCC	Reproductive_System_MMHCC	Female Reproductive System (MMHCC)
C22654	Clitoral_Gland_MMHCC	Female_Reproductive_System_MMHCC	Clitoral Gland (MMHCC)
C22655	Clitoris_MMHCC	Female_Reproductive_System_MMHCC	Clitoris (MMHCC)
C22656	Ovary_MMHCC	Female_Reproductive_System_MMHCC	Ovary (MMHCC)
C22657	Ovary_Capsule_MMHCC	Ovary_MMHCC	Ovary - Capsule (MMHCC)|Capsule of Ovary|Ovarian Capsule
C22658	Ovary_Germinal_Epithelium_MMHCC	Ovary_MMHCC	Ovary - Germinal Epithelium (MMHCC)|Germinal Epithelium of Ovary
C22659	Ovary_Germ_Cell_MMHCC	Ovary_MMHCC	Ovary - Germ Cell (MMHCC)|Egg Cell
C22660	Ovary_Follicle_MMHCC	Ovary_MMHCC	Ovary - Follicle (MMHCC)|Ovarian Follicle
C22661	Ovary_Follicular_Cell_MMHCC	Ovary_MMHCC	Ovary - Follicular Cell (MMHCC)|Follicular Ovarian Cells
C22662	Ovary_Granulosa_Cell_MMHCC	Ovary_MMHCC	Ovary - Granulosa Cell (MMHCC)|Granulosa Cell
C22663	Ovary_Interstitial_Cell_MMHCC	Ovary_MMHCC	Ovary - Interstitial Cell (MMHCC)
C22664	Ovary_Lutein_Cell_MMHCC	Ovary_MMHCC	Ovary - Lutein Cell (MMHCC)|Luteal Cell|Lutein Cell
C22665	Ovary_Sertoli_Cell_MMHCC	Ovary_MMHCC	Ovary - Sertoli Cell (MMHCC)
C22666	Ovary_Theca_Cell_MMHCC	Ovary_MMHCC	Ovary - Theca Cell (MMHCC)|Theca Cell
C22667	Oviduct_MMHCC	Female_Reproductive_System_MMHCC	Oviduct (MMHCC)
C22668	Placenta_MMHCC	Female_Reproductive_System_MMHCC	Placenta (MMHCC)
C22669	Placenta_Trophoblast_MMHCC	Placenta_MMHCC	Placenta - Trophoblast (MMHCC)|Trophoblast
C22670	Rete_Ovarii_MMHCC	Female_Reproductive_System_MMHCC	Rete Ovarii (MMHCC)
C22671	Uterus_MMHCC	Female_Reproductive_System_MMHCC	Uterus (MMHCC)
C22672	Uterus_Cervix_MMHCC	Uterus_MMHCC	Uterus - Cervix (MMHCC)|Cervix|Cervix Uteri|Uterine Cervix
C22673	Uterus_Endometrium_MMHCC	Uterus_MMHCC	Uterus - Endometrium (MMHCC)|Endometrium
C22674	Uterus_Myometrium_MMHCC	Uterus_MMHCC	Uterus - Myometrium (MMHCC)|Myometrium
C22675	Uterus_Serosa_MMHCC	Uterus_MMHCC	Uterus - Serosa (MMHCC)|Perimetrium|Uterine Serosa
C22676	Vagina_MMHCC	Female_Reproductive_System_MMHCC	Vagina (MMHCC)
C22677	Vulva_MMHCC	Female_Reproductive_System_MMHCC	Vulva (MMHCC)
C22678	Yolk_Sac_MMHCC	Female_Reproductive_System_MMHCC	Yolk Sac (MMHCC)
C22679	Skeletal_System_MMHCC	Musculoskeletal_System_MMHCC	Skeletal System (MMHCC)
C22680	Osteoblast_MMHCC	Skeletal_System_MMHCC	Osteoblast (MMHCC)
C22681	Osteoclast_MMHCC	Skeletal_System_MMHCC	Osteoclast (MMHCC)
C22682	Bone_MMHCC	Skeletal_System_MMHCC	Bone (MMHCC)
C22683	Bone_Jaw_MMHCC	Bone_MMHCC	Bone - Jaw (MMHCC)|Jaw Bone
C22684	Bone_Skull_MMHCC	Bone_MMHCC	Bone - Skull (MMHCC)|Skull
C22685	Soft_Tissues_MMHCC	Musculoskeletal_System_MMHCC	Soft Tissues (MMHCC)
C22686	Mesodermal_Cell_Mesoblast_MMHCC	Soft_Tissues_MMHCC	Mesodermal Cell / Mesoblast (MMHCC)|Mesoblast|Mesoderm
C22687	Lymphatic_Vessel_MMHCC	Soft_Tissues_MMHCC	Lymphatic Vessel (MMHCC)
C22688	Cartilage_MMHCC	Soft_Tissues_MMHCC	Cartilage (MMHCC)
C22689	Ligament_MMHCC	Soft_Tissues_MMHCC	Ligament (MMHCC)
C22690	Tendon_MMHCC	Soft_Tissues_MMHCC	Tendon (MMHCC)
C22691	Muscle_MMHCC	Soft_Tissues_MMHCC	Muscle (MMHCC)
C22692	Muscle_Immature_MMHCC	Muscle_MMHCC	Muscle - Immature (MMHCC)|Immature Muscle
C22693	Muscle_Smooth_MMHCC	Muscle_MMHCC	Muscle - Smooth (MMHCC)|Smooth Muscle
C22694	Muscle_Striated_MMHCC	Muscle_MMHCC	Muscle - Striated (MMHCC)
C22695	Muscle_Striated_Cardiac_MMHCC	Muscle_Striated_MMHCC	Muscle - Striated (Cardiac) (MMHCC)|Cardiac Muscle
C22696	Muscle_Striated_Skeletal_MMHCC	Muscle_Striated_MMHCC	Muscle - Striated (Skeletal) (MMHCC)|Skeletal Muscle
C22697	Myoepitheliocyte_MMHCC	Soft_Tissues_MMHCC	Myoepitheliocyte (MMHCC)
C22698	Muscle_Striated_Skeletal_Diaphragm_MMHCC	Muscle_Striated_Skeletal_MMHCC	Muscle - Striated (Skeletal) - Diaphragm (MMHCC)|Diaphragm
C22699	Connective_Tissue_MMHCC	Soft_Tissues_MMHCC	Connective Tissue (MMHCC)
C22700	Connective_Tissue_Fibroblasts_MMHCC	Connective_Tissue_MMHCC	Connective Tissue - Fibroblasts (MMHCC)|Fibroblast
C22701	Connective_Tissue_Mesentery_MMHCC	Connective_Tissue_MMHCC	Connective Tissue - Mesentery (MMHCC)|Mesentery
C22702	Connective_Tissue_Mesothelium_MMHCC	Connective_Tissue_MMHCC	Connective Tissue - Mesothelium (MMHCC)|Mesothelial Tissue|Mesothelium
C22703	Adipose_Tissue_MMHCC	Soft_Tissues_MMHCC	Adipose Tissue (MMHCC)|Fatty Tissue	Usually refers to white fat unless specified as brown.
C22704	Adipose_Tissue_Brown_MMHCC	Adipose_Tissue_MMHCC	Adipose Tissue - Brown (MMHCC)|Brown Adipose Tissue|Brown Fat
C22705	Adipose_Tissue_White_MMHCC	Adipose_Tissue_MMHCC	Adipose Tissue - White (MMHCC)|White Fat
C22706	Mediastinum_MMHCC	Soft_Tissues_MMHCC	Mediastinum (MMHCC)
C22707	Periosteum_MMHCC	Soft_Tissues_MMHCC	Periosteum (MMHCC)
C22708	Peritoneum_MMHCC	Soft_Tissues_MMHCC	Peritoneum (MMHCC)
C22709	Synovial_Membrane_MMHCC	Soft_Tissues_MMHCC	Synovial Membrane (MMHCC)
C22710	Special_Sensory_Organs_MMHCC	Murine_Tissue_Type	Special Sensory Organs (MMHCC)|Sensory Organ
C22711	Eye_MMHCC	Special_Sensory_Organs_MMHCC	Eye (MMHCC)
C22712	Ear_MMHCC	Special_Sensory_Organs_MMHCC	Ear (MMHCC)
C22713	Ear_Inner_Ear_Cochlea_MMHCC	Ear_MMHCC	Ear - Inner Ear/ Cochlea (MMHCC)|Inner Ear
C22714	Ear_Middle_Ear_MMHCC	Ear_MMHCC	Ear - Middle Ear (MMHCC)|Middle Ear
C22715	Ear_Outer_Ear_External_MMHCC	Ear_MMHCC	Ear - Outer Ear/ External (MMHCC)|Outer Ear
C22716	Eye_Conjunctiva_MMHCC	Eye_MMHCC	Eye - Conjunctiva (MMHCC)|Conjunctiva
C22717	Eye_Cornea_MMHCC	Eye_MMHCC	Eye - Cornea (MMHCC)|Cornea
C22718	Eye_Iris_MMHCC	Eye_MMHCC	Eye - Iris (MMHCC)|Iris
C22719	Eye_Harderian_Gland_MMHCC	Eye_MMHCC	Eye - Harderian Gland (MMHCC)|Harderian Gland
C22720	Eye_Lacrimal_Gland_MMHCC	Eye_MMHCC	Eye - Lacrimal Gland (MMHCC)|Lacrimal Gland
C22721	Eye_Lens_MMHCC	Eye_MMHCC	Eye - Lens (MMHCC)|Lens|Lens of Eye
C22722	Eye_Retina_MMHCC	Eye_MMHCC	Eye - Retina (MMHCC)|Retina
C22723	Nose_MMHCC	Special_Sensory_Organs_MMHCC	Nose (MMHCC)
C22724	Nose_Nasal_Cavity_MMHCC	Nose_MMHCC	Nose - Nasal Cavity (MMHCC)|Nasal Cavity
C22725	Nose_Nasal_Cavity_Nasal_Gland_MMHCC	Nose_Nasal_Cavity_MMHCC	Nose - Nasal Cavity - Nasal Gland (MMHCC)|Nasal Gland
C22726	Nose_Nasal_Cavity_Olfactory_Cell_MMHCC	Nose_Nasal_Cavity_MMHCC	Nose - Nasal Cavity - Olfactory Cell (MMHCC)|Olfactory Cell|Olfactory Receptor Cells
C22727	Nose_Olfactory_Glands_MMHCC	Nose_MMHCC	Nose - Olfactory Glands (MMHCC)|Olfactory Glands
C22728	Urinary_System_MMHCC	Murine_Tissue_Type	Urinary System (MMHCC)
C22729	Bladder_MMHCC	Urinary_System_MMHCC	Bladder (MMHCC)
C22730	Kidney_MMHCC	Urinary_System_MMHCC	Kidney (MMHCC)
C22731	Kidney_Cortex_MMHCC	Kidney_MMHCC	Kidney - Cortex (MMHCC)|Cortex of Kidney|Renal Cortex
C22732	Kidney_Cortex_Glomerulus_MMHCC	Kidney_Cortex_MMHCC	Kidney - Cortex - Glomerulus (MMHCC)|Kidney Glomerulus|Renal Glomerulus
C22733	Kidney_Cortex_Renal_Tubule_MMHCC	Kidney_Cortex_MMHCC	Kidney - Cortex - Renal Tubule (MMHCC)|Kidney Tubule|Renal Tubule
C22734	Kidney_Cortex_Renal_Tubule_Collecting_Duct_MMHCC	Kidney_Cortex_Renal_Tubule_MMHCC	Kidney - Cortex - Renal Tubule - Collecting Duct (MMHCC)|Kidney Collecting Ducts
C22735	Kidney_Cortex_Renal_Tubule_Loop_of_Henle_MMHCC	Kidney_Cortex_Renal_Tubule_MMHCC	Kidney - Cortex - Renal Tubule - Loop of Henle (MMHCC)|Henle's Loop|Loop of Henle
C22736	Kidney_Medulla_MMHCC	Kidney_MMHCC	Kidney - Medulla (MMHCC)|Medulla of Kidney|Renal Medulla
C22737	Renal_Pelvis_MMHCC	Urinary_System_MMHCC	Renal Pelvis (MMHCC)
C22738	Ureter_MMHCC	Urinary_System_MMHCC	Ureter (MMHCC)
C22739	Urethra_MMHCC	Urinary_System_MMHCC	Urethra (MMHCC)
C22740	Urethra_Gland_MMHCC	Urethra_MMHCC	Urethra - Gland (MMHCC)|Urethral Gland
C22741	Mouse_Ovarian_Tumors_Histological_Classification	Retired_Concepts	Mouse Ovarian Tumors: Histological Classification|Ovarian Tumors: Histological Classification
C22742	Surface_Epithelial-Stromal_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Surface Epithelial-Stromal Tumors of the Mouse Ovary|Surface Epithelial-Stromal Tumors of the Ovary
C22743	Serous_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Serous Tumors of the Mouse Ovary|Serous Tumors of the Ovary
C22744	Benign_Serous_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Benign Serous Tumors of the Mouse Ovary|Benign Serous Tumors of the Ovary
C22745	Serous_Cystadenoma_of_the_Mouse_Ovary	Retired_Concepts	Serous Cystadenoma of the Mouse Ovary|Serous Cystadenoma of the Ovary|Serous Ovarian Cystadenoma
C22746	Papillary_Serous_Cystadenoma_of_the_Mouse_Ovary	Retired_Concepts	Papillary Serous Cystadenoma of the Mouse Ovary|Papillary Serous Cystadenoma of the Ovary
C22747	Surface_Papilloma_of_the_Mouse_Ovary	Retired_Concepts	Surface Papilloma of the Mouse Ovary|Surface Papilloma of the Ovary
C22748	Serous_Adenofibroma_of_the_Mouse_Ovary_Benign_Serous_Cystadenofibroma_of_the_Mouse_Ovary	Retired_Concepts	Serous Adenofibroma of the Mouse Ovary; Benign Serous Cystadenofibroma of the Mouse Ovary|Serous Adenofibroma of the Ovary; Benign Serous Cystadenofibroma of the Ovary
C22749	Mouse_Serous_Ovarian_Tumors_of_Borderline_Malignancy	Retired_Concepts	Mouse Serous Ovarian Tumors of Borderline Malignancy|Serous Ovarian Tumors of Borderline Malignancy|Serous Tumors of the Ovary of Low Malignant Potential
C22750	Mouse_Serous_Cystic_Ovarian_Tumors_of_Borderline_Malignancy	Retired_Concepts	Mouse Serous Cystic Ovarian Tumors of Borderline Malignancy|Atypical Proliferative Serous Tumors of the Ovary|Serous Cystic Ovarian Tumors of Borderline Malignancy
C22751	Mouse_Papillary_Serous_Cystic_Ovarian_Tumors_of_Borderline_Malignancy	Retired_Concepts	Mouse Papillary Serous Cystic Ovarian Tumors of Borderline Malignancy|Papillary Serous Cystic Ovarian Tumors of Borderline Malignancy
C22752	Mouse_Surface_Papillary_Serous_Ovarian_Tumors_of_Borderline_Malignancy	Retired_Concepts	Mouse Surface Papillary Serous Ovarian Tumors of Borderline Malignancy|Surface Papillary Serous Ovarian Tumors of Borderline Malignancy
C22753	Mouse_Serous_Ovarian_Adenofibroma_of_Borderline_Malignancy_Mouse_Serous_Ovarian_Cystadenofibroma_of_Borderline_Malignancy	Retired_Concepts	Mouse Serous Ovarian Adenofibroma of Borderline Malignancy; Mouse Serous Ovarian Cystadenofibroma of Borderline Malignancy|Serous Ovarian Adenofibroma of Borderline Malignancy; Serous Ovarian Cystadenofibroma of Borderline Malignancy
C22754	Malignant_Serous_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Malignant Serous Tumors of the Mouse Ovary|Malignant Serous Tumors of the Ovary
C22755	Serous_Adenocarcinoma_of_the_Mouse_Ovary	Retired_Concepts	Serous Adenocarcinoma of the Mouse Ovary|Serous Adenocarcinoma of the Ovary
C22756	Papillary_Serous_Adenocarcinoma_of_the_Mouse_Ovary	Retired_Concepts	Papillary Serous Adenocarcinoma of the Mouse Ovary|Papillary Serous Adenocarcinoma of the Ovary
C22757	Papillary_Serous_Cystadenocarcinoma_of_the_Mouse_Ovary	Retired_Concepts	Papillary Serous Cystadenocarcinoma of the Mouse Ovary|Papillary Serous Cystadenocarcinoma of the Ovary
C22758	Surface_Papillary_Serous_Adenocarcinoma_of_the_Mouse_Ovary	Retired_Concepts	Surface Papillary Serous Adenocarcinoma of the Mouse Ovary|Surface Papillary Serous Adenocarcinoma of the Ovary
C22759	Serous_Adenocarcinofibroma_of_the_Mouse_Ovary_Serous_Cystadenocarcinofibroma_of_the_Mouse_Ovary	Retired_Concepts	Serous Adenocarcinofibroma of the Mouse Ovary; Serous Cystadenocarcinofibroma of the Mouse Ovary|Malignant Serous Adenofibroma|Malignant Serous Cystadenofibroma|Serous Adenocarcinofibroma of the Ovary; Serous Cystadenocarcinofibroma of the Ovary
C22760	Mucinous_Tumors_of_the_Mouse_Ovary_Endocervical-like_and_Intestinal_Types	Retired_Concepts	Mucinous Tumors of the Mouse Ovary, Endocervical-like and Intestinal Types|Mucinous Tumors of the Ovary, Endocervical-like and Intestinal Types
C22761	Benign_Mucinous_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Benign Mucinous Tumors of the Mouse Ovary|Benign Mucinous Tumors of the Ovary
C22762	Mucinous_Cystadenoma_of_the_Mouse_Ovary	Retired_Concepts	Mucinous Cystadenoma of the Mouse Ovary|Mucinous Cystadenoma of the Ovary|Mucinous Ovarian Cystadenoma
C22763	Mucinous_Adenofibroma_of_the_Mouse_Ovary_Mucinous_Cystadenofibroma_of_the_Mouse_Ovary	Retired_Concepts	Mucinous Adenofibroma of the Mouse Ovary; Mucinous Cystadenofibroma of the Mouse Ovary|Mucinous Adenofibroma|Mucinous Adenofibroma of the Ovary; Mucinous Cystadenofibroma of the Ovary|Mucinous Cystadenofibroma
C22764	Mucinous_Tumors_of_the_Mouse_Ovary_of_Borderline_Malignancy	Retired_Concepts	Mucinous Tumors of the Mouse Ovary of Borderline Malignancy|Mucinous Tumors of the Ovary of Borderline Malignancy|Mucinous Tumors of the Ovary of Low Malignant Potential
C22765	Mucinous_Cystic_Tumors_of_the_Mouse_Ovary_of_Borderline_Malignancy	Retired_Concepts	Mucinous Cystic Tumors of the Mouse Ovary of Borderline Malignancy|Atypical Proliferative Mucinous Tumors of the Ovary of Borderline Malignancy|Borderline Mucinous Cystadenoma|Mucinous Cystadenofibroma of Borderline Malignancy|Mucinous Cystic Tumors of the Ovary of Borderline Malignancy
C22766	Mucinous_Adenofibroma_of_the_Mouse_Ovary_of_Borderline_Malignancy_Mucinous_Cystadenofibroma_of_the_Mouse_Ovary_of_Borderline_Malignancy	Retired_Concepts	Mucinous Adenofibroma of the Mouse Ovary of Borderline Malignancy; Mucinous Cystadenofibroma of the Mouse Ovary of Borderline Malignancy|Mucinous Adenofibroma of the Ovary of Borderline Malignancy; Mucinous Cystadenofibroma of the Ovary of Borderline Malignancy
C22767	Malignant_Mucinous_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Malignant Mucinous Tumors of the Mouse Ovary|Malignant Mucinous Tumors of the Ovary
C22768	Mucinous_Adenocarcinoma_of_the_Mouse_Ovary	Retired_Concepts	Mucinous Adenocarcinoma of the Mouse Ovary|Mucinous Adenocarcinoma of the Ovary
C22769	Mucinous_Cystadenocarcinoma_of_the_Mouse_Ovary	Retired_Concepts	Mucinous Cystadenocarcinoma of the Mouse Ovary|Mucinous Cystadenocarcinoma of the Ovary
C22770	Mucinous_Adenocarcinofibroma_of_the_Mouse_Ovary_Mucinous_Cystadenocarcinofibroma_of_the_Mouse_Ovary	Retired_Concepts	Mucinous Adenocarcinofibroma of the Mouse Ovary; Mucinous Cystadenocarcinofibroma of the Mouse Ovary|Malignant Mucinous Adenofibroma|Malignant Mucinous Cystadenofibroma|Mucinous Adenocarcinofibroma of the Ovary; Mucinous Cystadenocarcinofibroma of the Ovary
C22771	Mouse_Endometrioid_Tumors	Retired_Concepts	Mouse Endometrioid Tumors|Endometrioid Tumors
C22772	Benign_Endometrioid_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Benign Endometrioid Tumors of the Mouse Ovary|Benign Endometrioid Tumors of the Ovary
C22773	Endometrioid_Cystadenoma_of_the_Mouse_Ovary	Retired_Concepts	Endometrioid Cystadenoma of the Mouse Ovary|Benign Endometrioid Cystadenoma|Endometrioid Cystadenoma of the Ovary
C22774	Benign_Endometrioid_Cystadenoma_of_the_Mouse_Ovary_with_Squamous_Differentiation	Retired_Concepts	Benign Endometrioid Cystadenoma of the Mouse Ovary with Squamous Differentiation|Benign Endometrioid Cystadenoma of the Ovary with Squamous Differentiation
C22775	Endometrioid_Adenofibroma_of_the_Mouse_Ovary_Endrometrioid_Cystadenofibroma_of_the_Mouse_Ovary	Retired_Concepts	Endometrioid Adenofibroma of the Mouse Ovary; Endrometrioid Cystadenofibroma of the Mouse Ovary|Benign Endometrioid Cystadenofibroma; Benign Endrometrioid cystadenofibroma|Endometrioid Adenofibroma of the Ovary; Endrometrioid Cystadenofibroma of the Ovary
C22776	Benign_Endometrioid_Adenofibroma_of_the_Mouse_Ovary_Benign_Endometrioid_Cystadenofibroma_of_the_Mouse_Ovary_with_Squamous_Differentiation	Retired_Concepts	Benign Endometrioid Adenofibroma of the Mouse Ovary; Benign Endometrioid Cystadenofibroma of the Mouse Ovary with Squamous Differentiation|Benign Endometrioid Adenofibroma of the Ovary; Benign Endometrioid Cystadenofibroma of the Ovary with Squamous Differentiation
C22777	Mouse_Endometrioid_Ovarian_Tumors_of_Borderline_Malignancy	Retired_Concepts	Mouse Endometrioid Ovarian Tumors of Borderline Malignancy|Endometrioid Ovarian Tumors of Borderline Malignancy
C22778	Mouse_Endometrioid_Cystic_Ovarian_Tumors_of_Borderline_Malignancy	Retired_Concepts	Mouse Endometrioid Cystic Ovarian Tumors of Borderline Malignancy|Atypical Proliferative Endometrioid Tumors of the Ovary|Borderline Endometrioid Cystadenoma|Endometrioid Cystic Ovarian Tumors of Borderline Malignancy
C22779	Mouse_Endometrioid_Cystic_Ovarian_Tumors_of_Borderline_Malignancy_with_Squamous_Differentiation	Retired_Concepts	Mouse Endometrioid Cystic Ovarian Tumors of Borderline Malignancy with Squamous Differentiation|Endometrioid Cystic Ovarian Tumors of Borderline Malignancy with Squamous Differentiation
C22780	Mouse_Endometrioid_Ovarian_Adenofibroma_of_Borderline_Malignancy_Mouse_Endometrioid_Ovarian_Cystadenofibroma_of_Borderline_Malignancy	Retired_Concepts	Mouse Endometrioid Ovarian Adenofibroma of Borderline Malignancy; Mouse Endometrioid Ovarian Cystadenofibroma of Borderline Malignancy|Endometrioid Ovarian Adenofibroma of Borderline Malignancy; Endometrioid Ovarian Cystadenofibroma of Borderline Malignancy
C22781	Mouse_Endometrioid_Ovarian_Adenofibroma_of_Borderline_Malignancy_Mouse_Endometrioid_Ovarian_Cystadenofibroma_of_Borderline_Malignancy_with_Squamous_Differentiation	Retired_Concepts	Mouse Endometrioid Ovarian Adenofibroma of Borderline Malignancy; Mouse Endometrioid Ovarian Cystadenofibroma of Borderline Malignancy with Squamous Differentiation|Endometrioid Ovarian Adenofibroma of Borderline Malignancy; Endometrioid Ovarian Cystadenofibroma of Borderline Malignancy with Squamous Differentiation
C22782	Malignant_Endometrioid_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Malignant Endometrioid Tumors of the Mouse Ovary|Malignant Endometrioid Tumors of the Ovary
C22783	Endometrioid_Adenocarcinoma_of_the_Mouse_Ovary_Endometrioid_Cystadenocarcinoma_of_the_Mouse_Ovary	Retired_Concepts	Endometrioid Adenocarcinoma of the Mouse Ovary; Endometrioid Cystadenocarcinoma of the Mouse Ovary|Endometrioid Adenocarcinoma of the Ovary; Endometrioid Cystadenocarcinoma of the Ovary
C22784	Endometrioid_Adenocarcinoma_of_the_Mouse_Ovary_Endometrioid_Cystadenocarcinoma_of_the_Mouse_Ovary_with_Squamous_Differentiation	Retired_Concepts	Endometrioid Adenocarcinoma of the Mouse Ovary; Endometrioid Cystadenocarcinoma of the Mouse Ovary with Squamous Differentiation|Endometrioid Adenocarcinoma of the Ovary; Endometrioid Cystadenocarcinoma of the Ovary with Squamous Differentiation
C22785	Endometrioid_Adenocarcinoma_of_the_Mouse_Ovary_Endometrioid_Cystadenocarcinofibroma_of_the_Mouse_Ovary	Retired_Concepts	Endometrioid Adenocarcinoma of the Mouse Ovary; Endometrioid Cystadenocarcinofibroma of the Mouse Ovary|Endometrioid Adenocarcinoma of the Ovary; Endometrioid Cystadenocarcinofibroma of the Ovary|Malignant Endometrioid Adenofibroma|Malignant Endometrioid Cystadenofibroma
C22786	Endometrioid_Adenocarcinoma_of_the_Mouse_Ovary_Endometrioid_Cystadenocarcinofibroma_of_the_Mouse_Ovary_with_Squamous_Differentiation	Retired_Concepts	Endometrioid Adenocarcinoma of the Mouse Ovary; Endometrioid Cystadenocarcinofibroma of the Mouse Ovary with Squamous Differentiation|Endometrioid Adenocarcinoma of the Ovary; Endometrioid Cystadenocarcinofibroma of the Ovary with Squamous Differentiation|Malignant Endometrioid Adenofibroma|Malignant Endometrioid Cystadenofibroma with squamous differentiation
C22787	Epithelial-Stromal_and_Stromal_Endometrioid_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Epithelial-Stromal and Stromal Endometrioid Tumors of the Mouse Ovary|Epithelial-Stromal and Stromal Endometrioid Tumors of the Ovary
C22788	Endometrioid_Adenosarcoma_of_the_Mouse_Ovary_Homologous_Heterologous	Retired_Concepts	Endometrioid Adenosarcoma of the Mouse Ovary, Homologous; Heterologous|Endometrioid Adenosarcoma of the Ovary, Homologous; Heterologous
C22789	Malignant_Mesodermal_Mullerian_Mixed_Tumor_of_the_Mouse_Ovary_carcinosarcoma_Homologous_Heterologous	Retired_Concepts	Malignant Mesodermal / Mullerian Mixed Tumor of the Mouse Ovary (carcinosarcoma), Homologous; Heterologous|Malignant Mesodermal / Mullerian Mixed Tumor of the Ovary (carcinosarcoma), Homologous; Heterologous
C22790	Stromal_Sarcoma_of_the_Mouse_Ovary	Retired_Concepts	Stromal Sarcoma of the Mouse Ovary|Endometrial Stromal Sarcoma|Stromal Sarcoma of the Ovary
C22791	Clear_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Clear Cell Tumors of the Mouse Ovary|Clear Cell Tumors of the Ovary
C22792	Benign_Clear_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Benign Clear Cell Tumors of the Mouse Ovary|Benign Clear Cell Tumors of the Ovary
C22793	Clear_Cell_Cystadenoma_of_the_Mouse_Ovary	Retired_Concepts	Clear Cell Cystadenoma of the Mouse Ovary|Benign Clear Cell Cystadenoma of Ovary|Clear Cell Cystadenoma of the Ovary
C22794	Clear_Cell_Adenofibroma_of_the_Mouse_Ovary_Clear_Cell_Cystadenofibroma_of_the_Mouse_Ovary	Retired_Concepts	Clear Cell Adenofibroma of the Mouse Ovary; Clear Cell Cystadenofibroma of the Mouse Ovary|Clear Cell Adenofibroma of the Ovary; Clear Cell Cystadenofibroma of the Ovary
C22795	Mouse_Clear_Cell_Ovarian_Tumors_of_Borderline_Malignancy	Retired_Concepts	Mouse Clear Cell Ovarian Tumors of Borderline Malignancy|Clear Cell Ovarian Tumors of Borderline Malignancy
C22796	Mouse_Clear_Cell_Cystic_Ovarian_Tumor_of_Borderline_Malignancy	Retired_Concepts	Mouse Clear Cell Cystic Ovarian Tumor of Borderline Malignancy|Clear Cell Cystic Ovarian Tumor of Borderline Malignancy
C22797	Malignant_Clear_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Malignant Clear Cell Tumors of the Mouse Ovary|Malignant Clear Cell Tumors of the Ovary
C22798	Clear_Cell_Adenocarcinoma_of_the_Mouse_Ovary	Retired_Concepts	Clear Cell Adenocarcinoma of the Mouse Ovary|Clear Cell Adenocarcinoma|Clear Cell Adenocarcinoma of the Ovary
C22799	Clear_Cell_Adenocarcinofibroma_of_the_Mouse_Ovary_Clear_Cell_Cystadenocarcinofibroma_of_the_Mouse_Ovary	Retired_Concepts	Clear Cell Adenocarcinofibroma of the Mouse Ovary; Clear Cell Cystadenocarcinofibroma of the Mouse Ovary|Clear Cell Adenocarcinofibroma of the Ovary; Clear Cell Cystadenocarcinofibroma of the Ovary|Malignant Clear Cell Adenofibroma|Malignant Clear Cell Cystadenofibroma
C22800	Transitional_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Transitional Cell Tumors of the Mouse Ovary|Transitional Cell Tumors of the Ovary
C22801	Mouse_Brenner_Tumor	Retired_Concepts	Mouse Brenner Tumor|Brenner Tumor
C22802	Mouse_Proliferating_Brenner_Tumor_of_Borderline_Malignancy	Retired_Concepts	Mouse Proliferating Brenner Tumor of Borderline Malignancy|Proliferating Brenner Tumor of Borderline Malignancy
C22803	Malignant_Mouse_Brenner_Tumor	Retired_Concepts	Malignant Mouse Brenner Tumor|Malignant Brenner Tumor
C22804	Transitional_Cell_Non-Brenner_Type_Carcinoma_of_the_Ovary	Retired_Concepts	Transitional Cell Non-Brenner Type Carcinoma of the Ovary
C22805	Squamous_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Squamous Cell Tumors of the Mouse Ovary|Squamous Cell Tumors of the Ovary
C22806	Mixed_Epithelial_Tumors_of_the_Mouse_Ovary_specify_Components	Retired_Concepts	Mixed Epithelial Tumors of the Mouse Ovary (specify Components)|Mixed Epithelial Tumors of the Ovary (specify Components)
C22807	Benign_Mixed_Epithelial_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Benign Mixed Epithelial Tumors of the Mouse Ovary|Benign Mixed Epithelial Tumors of the Ovary|Mixed Cell Adenoma
C22808	Mouse_Mixed_Epithelial_Ovarian_Tumors_of_Borderline_Malignancy	Retired_Concepts	Mouse Mixed Epithelial Ovarian Tumors of Borderline Malignancy|Mixed Epithelial Ovarian Tumors of Borderline Malignancy
C22809	Malignant_Mixed_Epithelial_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Malignant Mixed Epithelial Tumors of the Mouse Ovary|Malignant Mixed Epithelial Tumors of the Ovary|Mixed Cell Adenocarcinoma
C22810	Undifferentiated_Carcinoma_of_the_Mouse_Ovary	Retired_Concepts	Undifferentiated Carcinoma of the Mouse Ovary|Undifferentiated Carcinoma of the Ovary
C22811	Sex_Cord-Stromal_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Sex Cord-Stromal Tumors of the Mouse Ovary|Sex Cord-Stromal Tumors of the Ovary
C22812	Granulosa-Stromal_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Granulosa-Stromal Cell Tumors of the Mouse Ovary|Granulosa-Stromal Cell Tumors of the Ovary
C22813	Granulosa_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Granulosa Cell Tumors of the Mouse Ovary|Granulosa Cell Tumors of the Ovary
C22814	Adult_Granulosa_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Adult Granulosa Cell Tumors of the Mouse Ovary|Adult Granulosa Cell Tumors of the Ovary
C22815	Juvenile_Granulosa_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Juvenile Granulosa Cell Tumors of the Mouse Ovary|Juvenile Granulosa Cell Tumors of the Ovary
C22816	Mouse_Thecoma-fibroma_Group	Retired_Concepts	Mouse Thecoma-fibroma Group|Thecoma-fibroma Group
C22817	Mouse_Thecoma	Retired_Concepts	Mouse Thecoma|Luteinized Thecoma|Thecoma|Thecoma, Luteinized|Thecoma, Typical
C22818	Fibroma_of_the_Mouse_Ovary	Retired_Concepts	Fibroma of the Mouse Ovary|Fibroma of the Ovary
C22819	Cellular_Fibroma_of_the_Mouse_Ovary	Retired_Concepts	Cellular Fibroma of the Mouse Ovary|Cellular Fibroma of the Ovary
C22820	Fibrosarcoma_of_the_Mouse_Ovary	Retired_Concepts	Fibrosarcoma of the Mouse Ovary|Fibrosarcoma of the Ovary
C22821	Stromal_Tumor_of_the_Mouse_Ovary_with_Minor_Sex_Cord_Elements	Retired_Concepts	Stromal Tumor of the Mouse Ovary with Minor Sex Cord Elements|Stromal Tumor of the Ovary with Minor Sex Cord Elements
C22822	Sclerosing_Stromal_Tumor_of_the_Mouse_Ovary	Retired_Concepts	Sclerosing Stromal Tumor of the Mouse Ovary|Sclerosing Stromal Tumor of the Ovary
C22823	Stromal_Luteoma_of_the_Mouse_Ovary	Retired_Concepts	Stromal Luteoma of the Mouse Ovary|Stromal Luteoma of the Ovary
C22824	Unclassified_Thecoma-Fibroma_Type_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Unclassified Thecoma-Fibroma Type Tumors of the Mouse Ovary|Thecoma-Fibroma Type Tumors of the Murine Ovary with Intermediate Characteristics|Thecoma-Fibroma Type Tumors of the Ovary with Intermediate Characteristics|Unclassified|Unclassified Thecoma-Fibroma Type Tumors of the Ovary
C22825	Other_Thecoma-Fibroma_Type_Tumors_of_the_Mouse_Ovary_Not_Specified	Retired_Concepts	Other Thecoma-Fibroma Type Tumors of the Mouse Ovary, Not Specified|Other Thecoma-Fibroma Type Tumors of the Ovary, Not Specified
C22826	Sertoli-Stromal_Cell_Tumors_of_the_Mouse_Ovary_Androblastomas	Retired_Concepts	Sertoli-Stromal Cell Tumors of the Mouse Ovary, Androblastomas|Sertoli-Stromal Cell Tumors of the Ovary, Androblastomas
C22827	Well_Differentiated_Sertoli-Stromal_Cell_Tumors_of_the_Ovary_and_Androblastomas	Retired_Concepts	Well Differentiated Sertoli-Stromal Cell Tumors of the Ovary and Androblastomas
C22828	Sertoli_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Sertoli Cell Tumors of the Mouse Ovary|Sertoli Cell Tumors of the Ovary|Tubular Androblastoma
C22829	Sertoli-Leydig_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Sertoli-Leydig Cell Tumors of the Mouse Ovary|Sertoli-Leydig Cell Tumors of the Ovary
C22830	Leydig_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Leydig Cell Tumors of the Mouse Ovary|Leydig Cell Tumors of the Ovary
C22831	Mouse_Sertoli-Leydig_Cell_Ovarian_Tumors_of_Intermediate_Differentiation	Retired_Concepts	Mouse Sertoli-Leydig Cell Ovarian Tumors of Intermediate Differentiation|Sertoli-Leydig Cell Ovarian Tumors of Intermediate Differentiation
C22832	Mouse_Sertoli-Leydig_Cell_Ovarian_Tumors_of_Intermediate_Differentiation_with_Heterologous_Elements	Retired_Concepts	Mouse Sertoli-Leydig Cell Ovarian Tumors of Intermediate Differentiation with Heterologous Elements|Sertoli-Leydig Cell Ovarian Tumors of Intermediate Differentiation with Heterologous Elements
C22833	Mouse_Sertoli-Leydig_Cell_Ovarian_Tumor_Poorly_Differentiated_sarcomatoid	Retired_Concepts	Mouse Sertoli-Leydig Cell Ovarian Tumor, Poorly Differentiated (sarcomatoid)|Sertoli-Leydig Cell Ovarian Tumor, Poorly Differentiated (sarcomatoid)
C22834	Mouse_Sertoli-Leydig_Cell_Tumor_Poorly_Differentiated_with_Heterologous_Elements	Retired_Concepts	Mouse Sertoli-Leydig Cell Tumor, Poorly Differentiated with Heterologous Elements|Sertoli-Leydig Cell Tumor, Poorly Differentiated with Heterologous Elements
C22835	Retiform_Sertoli-Stromal_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Retiform Sertoli-Stromal Cell Tumors of the Mouse Ovary|Retiform Sertoli-Stromal Cell Tumors of the Ovary
C22836	Mouse_Sertoli-Leydig_Cell_Tumor_Retiform_with_Heterologous_Elements	Retired_Concepts	Mouse Sertoli-Leydig Cell Tumor, Retiform, with Heterologous Elements|Sertoli-Leydig Cell Tumor, Retiform, with Heterologous Elements
C22837	Sex_Cord_Tumors_of_the_Mouse_Ovary_with_Annular_Tubules	Retired_Concepts	Sex Cord Tumors of the Mouse Ovary with Annular Tubules|Sex Cord Tumors of the Ovary with Annular Tubules
C22838	Mouse_Gynandroblastoma	Retired_Concepts	Mouse Gynandroblastoma|Gynandroblastoma
C22839	Unclassified_Sex_Cord_Stromal_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Unclassified Sex Cord - Stromal Tumors of the Mouse Ovary|Unclassified Sex Cord - Stromal Tumors of the Ovary
C22840	Steroid_Lipid_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Steroid / Lipid Cell Tumors of the Mouse Ovary|Steroid / Lipid Cell Tumors of the Ovary
C22841	Steroid_Stromal_Luteoma_of_the_Ovary	Retired_Concepts	Steroid Stromal Luteoma of the Ovary
C22842	Steroid_Leydig_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Steroid Leydig Cell Tumors of the Mouse Ovary|Steroid Leydig Cell Tumors of the Ovary
C22843	Hilus_Cell_Tumor_of_the_Mouse_Ovary	Retired_Concepts	Hilus Cell Tumor of the Mouse Ovary|Hilar Cell Tumors of the Ovary|Hilus Cell Tumor of the Ovary
C22844	Leydig_Cell_Tumor_of_the_Mouse_Ovary_Non-Hilar_Type	Retired_Concepts	Leydig Cell Tumor of the Mouse Ovary, Non-Hilar Type|Leydig Cell Tumor of the Ovary, Non-Hilar Type
C22845	Unclassified_Steroid_Lipid_Cell_Tumors_of_the_Mouse_Ovary_NOS	Retired_Concepts	Unclassified Steroid (Lipid) Cell Tumors of the Mouse Ovary (NOS)|Lipid Cell Tumors of the Ovary of Ovary|Steroid Cell Tumors of the Ovary, NOS|Unclassified Steroid (Lipid) Cell Tumors of the Ovary (NOS)
C22846	Germ_Cell_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Germ Cell Tumors of the Mouse Ovary|Germ Cell Tumors of the Ovary
C22847	Mouse_Dysgerminoma	Retired_Concepts	Mouse Dysgerminoma|Dysgerminoma|Ovarian Dysgerminoma
C22848	Mouse_Disgerminoma_Variant_with_Syncytiotrophoblast_Cells	Retired_Concepts	Mouse Disgerminoma Variant -- with Syncytiotrophoblast Cells|Disgerminoma Variant -- with Syncytiotrophoblast Cells
C22849	Yolk_Sac_Tumor_of_the_Mouse_Ovary	Retired_Concepts	Yolk Sac Tumor of the Mouse Ovary|Endodermal sinus tumor|Yolk Sac Tumor of the Ovary
C22850	Polyvesicular_Vitelline_Tumor_of_the_Mouse_Ovary	Retired_Concepts	Polyvesicular Vitelline Tumor of the Mouse Ovary|Polyvesicular Vitelline Tumor of the Ovary
C22851	Hepatoid_Yolk_Sac_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Hepatoid Yolk Sac Tumors of the Mouse Ovary|Hepatoid Yolk Sac Tumors of the Ovary
C22852	Glandular_Yolk_Sac_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Glandular Yolk Sac Tumors of the Mouse Ovary|Glandular Yolk Sac Tumors of the Ovary|Ovarian Glandular Yolk Sac Neoplasm
C22853	Mouse_Embryonal_Carcinoma	Retired_Concepts	Mouse Embryonal Carcinoma|Embryonal Carcinoma
C22854	Mouse_Polyembryoma	Retired_Concepts	Mouse Polyembryoma|Polyembryoma
C22855	Murine_Choriocarcinoma	Retired_Concepts	Mouse Choriocarcinoma|Choriocarcinoma|Chorioepithelioma
C22856	Teratomas_of_the_Mouse_Ovary	Retired_Concepts	Teratomas of the Mouse Ovary|Teratomas of the Ovary
C22857	Immature_Teratoma_of_the_Mouse_Ovary	Retired_Concepts	Immature Teratoma of the Mouse Ovary|Embryonal Teratoma|Immature Teratoma of the Ovary|Immature Teratoma, Malignant
C22858	Mature_Teratoma_of_the_Mouse_Ovary	Retired_Concepts	Mature Teratoma of the Mouse Ovary|Mature Teratoma of the Ovary
C22859	Mature_Solid_Teratoma_of_the_Mouse_Ovary	Retired_Concepts	Mature Solid Teratoma of the Mouse Ovary|Mature Solid Teratoma of the Ovary
C22860	Mature_Cystic_Teratoma_of_the_Mouse_Ovary	Retired_Concepts	Mature Cystic Teratoma of the Mouse Ovary|Dermoid Cyst|Mature Cystic Teratoma of the Ovary
C22861	Teratoma_of_the_Mouse_Ovary_with_Malignant_Transformation	Retired_Concepts	Teratoma of the Mouse Ovary with Malignant Transformation|Dermoid Cyst with Malignant Transformation|Dermoid Cyst with Secondary Tumors of the Ovary|Mature Teratoma with secondary tumor (specify type)|Teratoma of the Ovary with Malignant Transformation
C22862	Mature_Teratoma_of_the_Mouse_Ovary_Foetiform	Retired_Concepts	Mature Teratoma of the Mouse Ovary, Foetiform|Mature Teratoma of the Ovary, Foetiform
C22863	Monodermal_Teratoma_of_the_Mouse_Ovary	Retired_Concepts	Monodermal Teratoma of the Mouse Ovary|Monodermal Teratoma of the Ovary
C22864	Mouse_Struma_Ovarii	Retired_Concepts	Mouse Struma Ovarii|Struma Ovarii|Struma Ovarii Variant -- with secondary tumor (specify type)|Struma Ovarii, Malignant
C22865	Carcinoid_Tumor_of_the_Mouse_Ovary	Retired_Concepts	Carcinoid Tumor of the Mouse Ovary|Carcinoid Tumor of the Ovary|Insular Carcinoid Tumors of the Ovary|Trabecular Carcinoid Tumors of the Ovary
C22866	Strumal_Carcinoid_Tumor_of_the_Mouse_Ovary	Retired_Concepts	Strumal Carcinoid Tumor of the Mouse Ovary|Strumal Carcinoid Tumor of the Ovary
C22867	Goblet_Cell_Carcinoid_Tumor_of_the_Mouse_Ovary	Retired_Concepts	Goblet Cell Carcinoid Tumor of the Mouse Ovary|Goblet Cell Carcinoid Tumor of the Ovary
C22868	Neuroectodermal_Tumors_of_the_Mouse_Ovary_specify_Type	Retired_Concepts	Neuroectodermal Tumors of the Mouse Ovary (specify Type)|Neuroectodermal Tumors of the Ovary (specify Type)
C22869	Sebaceous_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Sebaceous Tumors of the Mouse Ovary|Sebaceous Tumors of the Ovary
C22870	Other_Monodermal_Teratomas_of_the_Mouse_Ovary	Retired_Concepts	Other Monodermal Teratomas of the Mouse Ovary|Other Monodermal Teratomas of the Ovary
C22871	Mixed_Germ_Cell_Tumors_of_the_Mouse_Ovary_specify_Components	Retired_Concepts	Mixed Germ Cell Tumors of the Mouse Ovary (specify Components)|Mixed Germ Cell Tumors of the Ovary (specify Components)
C22872	Gonadoblastoma_of_the_Mouse_Ovary	Retired_Concepts	Gonadoblastoma of the Mouse Ovary|Gonadoblastoma of the Ovary
C22873	Gonadoblastoma_Variant_of_the_Mouse_Ovary_with_Dysgerminoma_or_Other_Germ_Cell_Tumor	Retired_Concepts	Gonadoblastoma Variant of the Mouse Ovary -- with Dysgerminoma or Other Germ Cell Tumor|Gonadoblastoma Variant of the Ovary -- with Dysgerminoma or Other Germ Cell Tumor
C22874	Germ_Cell_Sex_Cord-Stromal_Tumors_of_the_Mouse_Ovary_of_Non-gonadoblastoma_Type	Retired_Concepts	Germ Cell - Sex Cord-Stromal Tumors of the Mouse Ovary of Non-gonadoblastoma Type|Germ Cell - Sex Cord-Stromal Tumors of the Ovary of Non-gonadoblastoma Type
C22875	Germ_Cell_Sex_Cord-stromal_Tumors_of_the_Mouse_Ovary_Non-gonadoblastoma_Variant_with_Dysgerminoma_or_Other_Germ_Cell_Tumor	Retired_Concepts	Germ Cell - Sex Cord-stromal Tumors of the Mouse Ovary, Non-gonadoblastoma, Variant -- with Dysgerminoma or Other Germ Cell Tumor|Germ Cell - Sex Cord-stromal Tumors of the Ovary, Non-gonadoblastoma, Variant -- with Dysgerminoma or Other Germ Cell Tumor
C22876	Mouse_Tumors_of_Rete_Ovarii	Retired_Concepts	Mouse Tumors of Rete Ovarii|Tumors of Rete Ovarii
C22877	Mouse_Adenoma_of_Rete_Ovarii	Retired_Concepts	Mouse Adenoma of Rete Ovarii|Adenoma of Rete Ovarii
C22878	Mouse_Cystadenoma_of_Rete_Ovarii	Retired_Concepts	Mouse Cystadenoma of Rete Ovarii|Cystadenoma of Rete Ovarii
C22879	Mouse_Adenocarcinoma_of_Rete_Ovarii	Retired_Concepts	Mouse Adenocarcinoma of Rete Ovarii|Adenocarcinoma of Rete Ovarii
C22880	Mesothelial_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Mesothelial Tumors of the Mouse Ovary|Mesothelial Tumors of the Ovary
C22881	Adenomatoid_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Adenomatoid Tumors of the Mouse Ovary|Adenomatoid Tumors of the Ovary
C22882	Mesothelioma_of_the_Mouse_Ovary	Retired_Concepts	Mesothelioma of the Mouse Ovary|Mesothelioma of the Ovary
C22883	Tumors_of_Uncertain_Origin_and_Miscellaneous_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Tumors of Uncertain Origin and Miscellaneous Tumors of the Mouse Ovary|Tumors of Uncertain Origin and Miscellaneous Tumors of the Ovary
C22884	Small_Cell_Carcinoma_of_the_Mouse_Ovary	Retired_Concepts	Small Cell Carcinoma of the Mouse Ovary|Small Cell Carcinoma of the Ovary
C22885	Tumors_of_the_Mouse_Ovary_of_Probable_Wolffian_Origin	Retired_Concepts	Tumors of the Mouse Ovary of Probable Wolffian Origin|Tumors of the Ovary of Probable Wolffian Origin
C22886	Hepatoid_Carcinoma_of_the_Mouse_Ovary	Retired_Concepts	Hepatoid Carcinoma of the Mouse Ovary|Hepatoid Carcinoma of the Ovary
C22887	Mouse_Myxoma	Retired_Concepts	Mouse Myxoma|Myxoma
C22888	Other_Tumors_of_the_Mouse_Ovary_of_Uncertain_Origin_or_Miscellaneous	Retired_Concepts	Other Tumors of the Mouse Ovary of Uncertain Origin or Miscellaneous|Other Tumors of the Ovary of Uncertain Origin or Miscellaneous
C22889	Gestational_Trophoblastic_Diseases_of_the_Mouse_Ovary	Retired_Concepts	Gestational Trophoblastic Diseases of the Mouse Ovary|Gestational Trophoblastic Diseases of the Ovary
C22890	Mouse_Soft_Tissue_Ovarian_Tumors_Not_Specific_to_Ovary	Retired_Concepts	Mouse Soft Tissue Ovarian Tumors Not Specific to Ovary|Soft Tissue Ovarian Tumors Not Specific to Ovary
C22891	Malignant_Lymphomas_Leukemias_and_Plasmacytoma_of_the_Mouse_Ovary	Retired_Concepts	Malignant Lymphomas, Leukemias and Plasmacytoma of the Mouse Ovary|Malignant Lymphomas, Leukemias and Plasmacytoma of the Ovary
C22892	Unclassified_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Unclassified Tumors of the Mouse Ovary|Unclassified Tumors of the Ovary
C22893	Secondary_Metastatic_Tumors_of_the_Mouse_Ovary	Retired_Concepts	Secondary / Metastatic Tumors of the Mouse Ovary|Secondary / Metastatic Tumors of the Ovary
C22894	Tumor-Like_Lesions_of_the_Ovary	Retired_Concepts	Tumor-Like Lesions of the Ovary
C22895	Solitary_Follicle_Cyst_of_the_Ovary	Retired_Concepts	Solitary Follicle Cyst of the Ovary
C22896	Multiple_Follicle_Cysts_of_the_Ovary	Retired_Concepts	Multiple Follicle Cysts of the Ovary|polycystic ovarian disease|sclerocystic ovaries
C22897	Large_Solitary_Luteinized_Follicle_Cyst_of_Pregnancy_and_Puerperium	Retired_Concepts	Large Solitary Luteinized Follicle Cyst of Pregnancy and Puerperium
C22898	Hyperreactio_Luteinalis	Retired_Concepts	Hyperreactio Luteinalis|multiple luteinized follicle cysts
C22899	Hyperreactio_Luteinalis_Variant_with_Corpora_Lutea	Retired_Concepts	Hyperreactio Luteinalis Variant -- with Corpora Lutea
C22900	Mouse_Corpus_Luteum_Cyst	Retired_Concepts	Corpus Luteum Cyst
C22901	Pregnancy_Luteoma	Retired_Concepts	Pregnancy Luteoma
C22902	Mouse_Ectopic_Pregnancy	Retired_Concepts	Ectopic Pregnancy
C22903	Mouse_Stromal_Hyperplasia	Retired_Concepts	Stromal Hyperplasia
C22904	Stromal_Hyperthecosis	Retired_Concepts	Stromal Hyperthecosis
C22905	Massive_Oedema	Retired_Concepts	Massive Oedema
C22906	Fibromatosis_of_the_Ovary	Retired_Concepts	Fibromatosis of the Ovary
C22907	Endometriosis_of_the_Ovary	Retired_Concepts	Endometriosis of the Ovary
C22908	Cyst_of_the_Ovary_Unclassified	Retired_Concepts	Cyst of the Ovary, Unclassified|simple cyst
C22909	Inflammatory_Lesions_of_the_Ovary	Retired_Concepts	Inflammatory Lesions of the Ovary
C22910	Mouse_Primary_Cardiac_Tumors	Mouse_Cardiovascular_System_Neoplasms	Mouse Primary Cardiac Tumors|Primary Cardiac Tumors
C22911	Mouse_Cardiac_Sarcoma	Mouse_Primary_Cardiac_Tumors|Mouse_Sarcoma	Mouse Cardiac Sarcoma|Cardiac Sarcoma
C22912	Mouse_Cardiac_Angiosarcoma	Mouse_Angiosarcoma|Mouse_Primary_Cardiac_Tumors	Mouse Cardiac Angiosarcoma|Cardiac Angiosarcoma
C22913	Mouse_Cardiac_Rhabdomyosarcoma	Mouse_Primary_Cardiac_Tumors|Mouse_Rhabdomyosarcoma	Mouse Cardiac Rhabdomyosarcoma|Cardiac Rhabdomyosarcoma
C22914	Mouse_Cardiac_Mesothelioma	Mouse_Mesothelioma|Mouse_Primary_Cardiac_Tumors	Mouse Cardiac Mesothelioma|Cardiac Mesothelioma
C22915	Mouse_Cardiac_Fibrosarcoma	Mouse_Fibrosarcoma|Mouse_Primary_Cardiac_Tumors	Mouse Cardiac Fibrosarcoma|Cardiac Fibrosarcoma
C22916	Mouse_Cardiac_Malignant_Fibrous_Histiocytoma	Mouse_Malignant_Mesenchymal_Neoplasm|Mouse_Primary_Cardiac_Tumors	Mouse Cardiac Malignant Fibrous Histiocytoma|Cardiac Malignant Fibrous Histiocytoma
C22917	Mouse_Cardiac_Kaposi_s_Sarcoma	Mouse_Kaposi_s_Sarcoma|Mouse_Primary_Cardiac_Tumors	Mouse Cardiac Kaposi's Sarcoma|Cardiac Kaposi's Sarcoma
C22918	Mouse_Cardiovascular_System_Neoplasms	Mouse_Cardiovascular_System_Disorder|Mouse_Neoplasms_by_Location	Mouse Cardiovascular System Neoplasms|Cardiovascular System Neoplasms
C22919	Mouse_Primary_Tumors_of_the_Blood_Vessel	Mouse_Cardiovascular_System_Neoplasms	Mouse Primary Tumors of the Blood Vessel|Primary Tumors of the Blood Vessel
C22920	Hemangioma_of_the_Mouse_Blood_Vessel	Mouse_Angioma|Mouse_Primary_Tumors_of_the_Blood_Vessel	Hemangioma of the Mouse Blood Vessel|Hemangioma of the Blood Vessel
C22921	Hemangiosarcoma_of_the_Mouse_Blood_Vessel	Hemangioma_of_the_Mouse_Blood_Vessel	Hemangiosarcoma of the Mouse Blood Vessel|Hemangiosarcoma of the Blood Vessel
C22922	Cavernous_Hemangioma_of_the_Mouse_Blood_Vessel	Hemangioma_of_the_Mouse_Blood_Vessel	Cavernous Hemangioma of the Mouse Blood Vessel|Cavernous Hemangioma of the Blood Vessel
C22923	Venous_Hemangioma_of_the_Mouse_Blood_Vessel	Hemangioma_of_the_Mouse_Blood_Vessel	Venous Hemangioma of the Mouse Blood Vessel|Venous Hemangioma of the Blood Vessel
C22924	Racemose_Hemangioma_of_the_Mouse_Blood_Vessel	Hemangioma_of_the_Mouse_Blood_Vessel	Racemose Hemangioma of the Mouse Blood Vessel|Racemose Hemangioma of the Blood Vessel
C22925	Epithelioid_Hemangioma_of_the_Mouse_Blood_Vessel_NOS	Epithelioid_Hemangioma_of_the_Mouse_Blood_Vessel	Epithelioid Hemangioma of the Mouse Blood Vessel, NOS|Epithelioid Hemangioma of the Blood Vessel, NOS
C22926	Epithelioid_Hemangioma_of_the_Mouse_Blood_Vessel_Malignant	Epithelioid_Hemangioma_of_the_Mouse_Blood_Vessel	Epithelioid Hemangioma of the Mouse Blood Vessel, Malignant|Epithelioid Hemangioma of the Blood Vessel, Malignant
C22927	Epithelioid_Hemangioma_of_the_Mouse_Blood_Vessel	Hemangioma_of_the_Mouse_Blood_Vessel	Epithelioid Hemangioma of the Mouse Blood Vessel|Epithelioid Hemangioma of the Blood Vessel
C22928	Hemangioma_of_the_Mouse_Blood_Vessel_NOS	Hemangioma_of_the_Mouse_Blood_Vessel	Hemangioma of the Mouse Blood Vessel, NOS|Hemangioma of the Blood Vessel, NOS
C22929	Hemangioendothelioma_of_the_Mouse_Blood_Vessel_Benign	Hemangioma_of_the_Mouse_Blood_Vessel	Hemangioendothelioma of the Mouse Blood Vessel, Benign|Hemangioendothelioma of the Blood Vessel, Benign
C22930	Hemangioendothelioma_of_the_Mouse_Blood_Vessel_NOS	Hemangioma_of_the_Mouse_Blood_Vessel	Hemangioendothelioma of the Mouse Blood Vessel, NOS|Hemangioendothelioma of the Blood Vessel, NOS
C22931	Hemangioendothelioma_of_the_Mouse_Blood_Vessel_Malignant	Hemangioma_of_the_Mouse_Blood_Vessel	Hemangioendothelioma of the Mouse Blood Vessel, Malignant|Hemangioendothelioma of the Blood Vessel, Malignant
C22932	Capillary_Hemangioma_of_the_Mouse_Blood_Vessel	Hemangioma_of_the_Mouse_Blood_Vessel	Capillary Hemangioma of the Mouse Blood Vessel|Capillary Hemangioma of the Blood Vessel
C22933	Intramuscular_Hemangioma_of_the_Mouse_Blood_Vessel	Hemangioma_of_the_Mouse_Blood_Vessel	Intramuscular Hemangioma of the Mouse Blood Vessel|Intramuscular Hemangioma of the Blood Vessel
C22934	Kupffer_Cell_Sarcoma_of_the_Mouse_Blood_Vessel	Mouse_Angiosarcoma|Mouse_Primary_Tumors_of_the_Blood_Vessel	Kupffer Cell Sarcoma of the Mouse Blood Vessel|Kupffer Cell Sarcoma of the Blood Vessel
C22935	Endovascular_Papillary_Angioendothelioma_of_the_Mouse_Blood_Vessel	Mouse_Primary_Tumors_of_the_Blood_Vessel	Endovascular Papillary Angioendothelioma of the Mouse Blood Vessel|Endovascular Papillary Angioendothelioma of the Blood Vessel
C22936	Spindle_Cell_Hemangioendothelioma_of_the_Mouse_Blood_Vessel	Hemangioma_of_the_Mouse_Blood_Vessel	Spindle Cell Hemangioendothelioma of the Mouse Blood Vessel|Spindle Cell Hemangioendothelioma of the Blood Vessel
C22937	Kaposi_Sarcoma_of_the_Mouse_Blood_Vessel	Mouse_Kaposi_s_Sarcoma|Mouse_Primary_Tumors_of_the_Blood_Vessel	Kaposi Sarcoma of the Mouse Blood Vessel|Kaposi Sarcoma of the Blood Vessel
C22938	Angiokeratoma_of_the_Mouse_Blood_Vessel	Mouse_Primary_Tumors_of_the_Blood_Vessel	Angiokeratoma of the Mouse Blood Vessel|Angiokeratoma of the Blood Vessel
C22939	Verrucous_Keratotic_Hemangioma_of_the_Mouse_Blood_Vessel	Hemangioma_of_the_Mouse_Blood_Vessel	Verrucous Keratotic Hemangioma of the Mouse Blood Vessel|Verrucous Keratotic Hemangioma of the Blood Vessel
C22940	Hemangiopericytoma_of_the_Mouse_Blood_Vessel_Benign	Hemangioma_of_the_Mouse_Blood_Vessel|Mouse_Hemangiopericytoma	Hemangiopericytoma of the Mouse Blood Vessel, Benign|Hemangiopericytoma of the Blood Vessel, Benign
C22941	Hemangiopericytoma_of_the_Mouse_Blood_Vessel_NOS	Hemangioma_of_the_Mouse_Blood_Vessel|Mouse_Hemangiopericytoma	Hemangiopericytoma of the Mouse Blood Vessel, NOS|Hemangiopericytoma of the Blood Vessel, NOS
C22942	Hemangiopericytoma_of_the_Mouse_Blood_Vessel_Malignant	Hemangioma_of_the_Mouse_Blood_Vessel|Mouse_Hemangiopericytoma	Hemangiopericytoma of the Mouse Blood Vessel, Malignant|Hemangiopericytoma of the Blood Vessel, Malignant
C22943	Angiofibroma_of_the_Mouse_Blood_Vessel_NOS	Mouse_Primary_Tumors_of_the_Blood_Vessel	Angiofibroma of the Mouse Blood Vessel, NOS|Angiofibroma of the Blood Vessel, NOS
C22944	Acquired_Tufted_Hemangioma_of_the_Mouse_Blood_Vessel	Hemangioma_of_the_Mouse_Blood_Vessel	Acquired Tufted Hemangioma of the Mouse Blood Vessel|Acquired Tufted Hemangioma of the Blood Vessel
C22945	Hemangioblastoma_of_the_Mouse_Blood_Vessel	Hemangioma_of_the_Mouse_Blood_Vessel	Hemangioblastoma of the Mouse Blood Vessel|Hemangioblastoma of the Blood Vessel
C22946	Mouse_Skeletal_System_Neoplasms	Mouse_Neoplasms_by_Location|Mouse_Skeletal_System_Disorder	Mouse Skeletal System Neoplasms|Mouse Skeletal System Diseases|Skeletal System Neoplasms
C22947	Osteoma_of_the_Mouse_Skeletal_System_NOS	Mouse_Skeletal_System_Neoplasms	Osteoma of the Mouse Skeletal System, NOS|Osteoma of the Skeletal System, NOS
C22948	Osteosarcoma_of_the_Mouse_Skeletal_System_NOS	Osteosarcoma_of_the_Mouse_Skeletal_System	Osteosarcoma of the Mouse Skeletal System, NOS|Osteosarcoma of the Skeletal System, NOS
C22949	Osteosarcoma_of_the_Mouse_Skeletal_System	Mouse_Osteosarcoma|Mouse_Skeletal_System_Neoplasms	Osteosarcoma of the Mouse Skeletal System|Osteosarcoma of the Skeletal System
C22950	Chondroblastic_Osteosarcoma_of_the_Mouse_Skeletal_System	Osteosarcoma_of_the_Mouse_Skeletal_System	Chondroblastic Osteosarcoma of the Mouse Skeletal System|Chondroblastic Osteosarcoma of the Skeletal System
C22951	Fibroblastic_Osteosarcoma_of_the_Mouse_Skeletal_System	Osteosarcoma_of_the_Mouse_Skeletal_System	Fibroblastic Osteosarcoma of the Mouse Skeletal System|Fibroblastic Osteosarcoma of the Skeletal System
C22952	Telangiectatic_Osteosarcoma_of_the_Mouse_Skeletal_System	Osteosarcoma_of_the_Mouse_Skeletal_System	Telangiectatic Osteosarcoma of the Mouse Skeletal System|Telangiectatic Osteosarcoma of the Skeletal System
C22953	Osteosarcoma_in_Paget_Disease_of_the_Mouse_Skeletal_System	Osteosarcoma_of_the_Mouse_Skeletal_System	Osteosarcoma in Paget Disease of the Mouse Skeletal System|Osteosarcoma in Paget Disease of the Skeletal System
C22954	Small_Cell_Osteosarcoma_of_the_Mouse_Skeletal_System	Osteosarcoma_of_the_Mouse_Skeletal_System	Small Cell Osteosarcoma of the Mouse Skeletal System|Small Cell Osteosarcoma of the Skeletal System
C22955	Central_Osteosarcoma_of_the_Mouse_Skeletal_System	Osteosarcoma_of_the_Mouse_Skeletal_System	Central Osteosarcoma of the Mouse Skeletal System|Central Osteosarcoma of the Skeletal System
C22956	Intraosseous_Well_Differentiated_Osteosarcoma_of_the_Mouse_Skeletal_System	Osteosarcoma_of_the_Mouse_Skeletal_System	Intraosseous Well Differentiated Osteosarcoma of the Mouse Skeletal System|Intraosseous Well Differentiated Osteosarcoma of the Skeletal System
C22957	Osteoid_Osteoma_of_the_Mouse_Skeletal_System_NOS	Mouse_Skeletal_System_Neoplasms	Osteoid Osteoma of the Mouse Skeletal System, NOS|Osteoid Osteoma of the Skeletal System, NOS
C22958	Parosteal_Osteosarcoma_of_the_Mouse_Skeletal_System	Osteosarcoma_of_the_Mouse_Skeletal_System	Parosteal Osteosarcoma of the Mouse Skeletal System|Parosteal Osteosarcoma of the Skeletal System
C22959	Periosteal_Osteosarcoma_of_the_Mouse_Skeletal_System	Osteosarcoma_of_the_Mouse_Skeletal_System	Periosteal Osteosarcoma of the Mouse Skeletal System|Periosteal Osteosarcoma of the Skeletal System
C22960	High_Grade_Surface_Osteosarcoma_of_the_Mouse_Skeletal_System	Osteosarcoma_of_the_Mouse_Skeletal_System	High Grade Surface Osteosarcoma of the Mouse Skeletal System|High Grade Surface Osteosarcoma of the Skeletal System
C22961	Intracortical_Osteosarcoma_of_the_Mouse_Skeletal_System	Osteosarcoma_of_the_Mouse_Skeletal_System	Intracortical Osteosarcoma of the Mouse Skeletal System|Intracortical Osteosarcoma of the Skeletal System
C22962	Osteoblastoma_of_the_Mouse_Skeletal_System_NOS	Mouse_Skeletal_System_Neoplasms	Osteoblastoma of the Mouse Skeletal System, NOS|Osteoblastoma of the Skeletal System, NOS
C22963	Aggressive_Osteoblastoma_of_the_Mouse_Skeletal_System	Mouse_Skeletal_System_Neoplasms	Aggressive Osteoblastoma of the Mouse Skeletal System|Aggressive Osteoblastoma of the Skeletal System
C22964	Osteochondroma_of_the_Mouse_Skeletal_System	Mouse_Chondrocyte_Neoplasm|Mouse_Skeletal_System_Neoplasms	Osteochondroma of the Mouse Skeletal System|Osteochondroma of the Skeletal System
C22965	Osteochondromatosis_of_the_Mouse_Skeletal_System_NOS	Mouse_Chondrocyte_Neoplasm|Mouse_Skeletal_System_Neoplasms	Osteochondromatosis of the Mouse Skeletal System, NOS|Osteochondromatosis of the Skeletal System, NOS
C22966	Chondroma_of_the_Mouse_Skeletal_System_NOS	Mouse_Chondrocyte_Neoplasm|Mouse_Skeletal_System_Neoplasms	Chondroma of the Mouse Skeletal System, NOS|Chondroma of the Skeletal System, NOS
C22967	Chondromatosis_of_the_Mouse_Skeletal_System_NOS	Mouse_Chondrocyte_Neoplasm|Mouse_Skeletal_System_Neoplasms	Chondromatosis of the Mouse Skeletal System, NOS|Chondromatosis of the Skeletal System, NOS
C22968	Chondrosarcoma_of_the_Mouse_Skeletal_System_NOS	Mouse_Chondrosarcoma|Mouse_Skeletal_System_Neoplasms	Chondrosarcoma of the Mouse Skeletal System, NOS|Chondrosarcoma of the Skeletal System, NOS
C22969	Juxtacortical_Chondroma_of_the_Mouse_Skeletal_System	Mouse_Chondrocyte_Neoplasm|Mouse_Skeletal_System_Neoplasms	Juxtacortical Chondroma of the Mouse Skeletal System|Juxtacortical Chondroma of the Skeletal System
C22970	Juxtacortical_Chondrosarcoma_of_the_Mouse_Skeletal_System	Mouse_Chondrosarcoma|Mouse_Skeletal_System_Neoplasms	Juxtacortical Chondrosarcoma of the Mouse Skeletal System|Juxtacortical Chondrosarcoma of the Skeletal System
C22971	Chondroblastoma_of_the_Mouse_Skeletal_System_NOS	Mouse_Chondrocyte_Neoplasm|Mouse_Skeletal_System_Neoplasms	Chondroblastoma of the Mouse Skeletal System, NOS|Chondroblastoma of the Skeletal System, NOS
C22972	Chondroblastoma_of_the_Mouse_Skeletal_System_Malignant	Mouse_Chondrocyte_Neoplasm|Mouse_Skeletal_System_Neoplasms	Chondroblastoma of the Mouse Skeletal System, Malignant|Chondroblastoma of the Skeletal System, Malignant
C22973	Myxoid_Chondrosarcoma_of_the_Mouse_Skeletal_System	Mouse_Chondrosarcoma|Mouse_Skeletal_System_Neoplasms	Myxoid Chondrosarcoma of the Mouse Skeletal System|Myxoid Chondrosarcoma of the Skeletal System
C22974	Mesenchymal_Chondrosarcoma_of_the_Mouse_Skeletal_System	Mouse_Chondrosarcoma|Mouse_Skeletal_System_Neoplasms	Mesenchymal Chondrosarcoma of the Mouse Skeletal System|Mesenchymal Chondrosarcoma of the Skeletal System
C22975	Chondromyxoid_Fibroma_of_the_Mouse_Skeletal_System	Mouse_Fibroma|Mouse_Skeletal_System_Neoplasms	Chondromyxoid Fibroma of the Mouse Skeletal System|Chondromyxoid Fibroma of the Skeletal System
C22976	Clear_Cell_Chondrosarcoma_of_the_Mouse_Skeletal_System	Mouse_Chondrosarcoma|Mouse_Skeletal_System_Neoplasms	Clear Cell Chondrosarcoma of the Mouse Skeletal System|Clear Cell Chondrosarcoma of the Skeletal System
C22977	Dedifferentiated_Chondrosarcoma_of_the_Mouse_Skeletal_System	Mouse_Chondrosarcoma|Mouse_Skeletal_System_Neoplasms	Dedifferentiated Chondrosarcoma of the Mouse Skeletal System|Dedifferentiated Chondrosarcoma of the Skeletal System
C22978	Giant_Cell_Tumor_of_Bone_of_the_Mouse_Skeletal_System_NOS	Mouse_Giant_Cell_Neoplasm|Mouse_Skeletal_System_Neoplasms	Giant Cell Tumor of Bone of the Mouse Skeletal System, NOS|Giant Cell Tumor of Bone of the Skeletal System, NOS
C22979	Giant_Cell_Tumor_of_Bone_of_the_Mouse_Skeletal_System_Malignant	Mouse_Giant_Cell_Neoplasm|Mouse_Skeletal_System_Neoplasms	Giant Cell Tumor of Bone of the Mouse Skeletal System, Malignant|Giant Cell Tumor of Bone of the Skeletal System, Malignant
C22980	Mouse_Endocrine_Gland_System_Neoplasms	Mouse_Endocrine_Gland_System_Disorder|Mouse_Neoplasms_by_Location	Mouse Endocrine Gland System Neoplasms|Endocrine Gland System Neoplasms
C22981	Murine_Islet_Cell_Adenoma	Retired_Concepts	Mouse Islet Cell Adenoma|Islet Cell Adenoma
C22982	Mouse_Islet_Cell_Tumor_NOS	Retired_Concepts	Mouse Islet Cell Tumor, NOS|Islet Cell Tumor, NOS
C22983	Murine_Islet_Cell_Carcinoma	Retired_Concepts	Mouse Islet Cell Carcinoma|Islet Cell Carcinoma
C22984	Mouse_Insulinoma_NOS	Retired_Concepts	Mouse Insulinoma, NOS|Insulinoma, NOS
C22985	Malignant_Mouse_Insulinoma	Retired_Concepts	Malignant Mouse Insulinoma|Malignant Insulinoma
C22986	Mouse_Glucagonoma_NOS	Retired_Concepts	Mouse Glucagonoma, NOS|Glucagonoma, NOS
C22987	Malignant_Mouse_Glucagonoma	Retired_Concepts	Malignant Mouse Glucagonoma|Malignant Glucagonoma
C22988	Mixed_Mouse_Islet_Cell_and_Exocrine_Adenocarcinoma	Retired_Concepts	Mixed Mouse Islet Cell and Exocrine Adenocarcinoma|Mixed Islet Cell and Exocrine Adenocarcinoma
C22989	Mouse_Pituitary_Adenoma_NOS	Mouse_Adenoma|Mouse_Pituitary_Gland_Neoplasms	Mouse Pituitary Adenoma, NOS|Pituitary Adenoma, NOS
C22990	Mouse_Pituitary_Carcinoma_NOS	Mouse_Carcinoma|Mouse_Pituitary_Gland_Neoplasms	Mouse Pituitary Carcinoma, NOS|Pituitary Carcinoma, NOS
C22991	Mouse_Adrenal_Cortical_Adenoma_NOS	Mouse_Adrenal_Cortical_Adenoma	Mouse Adrenal Cortical Adenoma, NOS|Adrenal Cortical Adenoma, NOS
C22992	Mouse_Adrenal_Cortical_Carcinoma	Mouse_Adrenal_Gland_Neoplasms|Mouse_Carcinoma	Mouse Adrenal Cortical Carcinoma|Adrenal Cortical Carcinoma
C22993	Mouse_Adrenal_Cortical_Adenoma_Compact_Cell	Mouse_Adrenal_Cortical_Adenoma	Mouse Adrenal Cortical Adenoma, Compact Cell|Adrenal Cortical Adenoma, Compact Cell
C22994	Mouse_Adrenal_Cortical_Adenoma	Mouse_Adenoma|Mouse_Adrenal_Gland_Neoplasms	Mouse Adrenal Cortical Adenoma|Adrenal Cortical Adenoma
C22995	Mouse_Adrenal_Cortical_Adenoma_Pigmented	Mouse_Adrenal_Cortical_Adenoma	Mouse Adrenal Cortical Adenoma, Pigmented|Adrenal Cortical Adenoma, Pigmented
C22996	Mouse_Adrenal_Cortical_Adenoma_Clear_Cell	Mouse_Adrenal_Cortical_Adenoma	Mouse Adrenal Cortical Adenoma, Clear Cell|Adrenal Cortical Adenoma, Clear Cell
C22997	Mouse_Adrenal_Cortical_Adenoma_Glomerulosa_Cell	Mouse_Adrenal_Cortical_Adenoma	Mouse Adrenal Cortical Adenoma, Glomerulosa Cell|Adrenal Cortical Adenoma, Glomerulosa Cell
C22998	Mouse_Adrenal_Cortical_Adenoma_Mixed_Cell	Mouse_Adrenal_Cortical_Adenoma	Mouse Adrenal Cortical Adenoma, Mixed Cell|Adrenal Cortical Adenoma, Mixed Cell
C22999	T_Cell_Neoplasms_of_Undetermined_Character_of_the_Mouse_Hematologic_System	T_Cell_Neoplasms_of_the_Mouse_Hematologic_System	T Cell Neoplasms of Undetermined Character of the Mouse Hematologic System|T Cell Neoplasms of Undetermined Character of the Hematologic System
C23000	Burkitt-like_Lymphoma_of_the_Mouse_Hematologic_System	Mature_B_Cell_Neoplasms_of_the_Mouse_Hematologic_System	Burkitt-like Lymphoma of the Mouse Hematologic System|BLL|Burkitt-like Lymphoma of the Hematologic System	Comment: including mature B-cell lymphomas with lymphoblastic morphology
C23001	Morphologic_Variants_of_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Morphologic Variants of Diffuse Large B Cell Lymphoma of the Mouse Hematologic System|Morphologic Variants of Diffuse Large B Cell Lymphoma of the Hematologic System
C23002	Subtypes_of_Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Diffuse_Large_B_Cell_Lymphoma_of_the_Mouse_Hematologic_System	Subtypes of Diffuse Large B Cell Lymphoma of the Mouse Hematologic System|Subtypes of Diffuse Large B Cell Lymphoma of the Hematologic System
C23003	Soft_Tissue_Tumors_of_the_Murine_Pulmonary_System	Retired_Concepts	Soft Tissue Tumors of the Murine Pulmonary System|Soft Tissue Tumors of the Pulmonary System
C23004	Mesothelial_Tumors_of_the_Mouse_Pulmonary_System	Retired_Concepts	Mesothelial Tumors of the Murine Pulmonary System|Mesothelial Tumors of the Pulmonary System
C23005	Miscellaneous_Tumors_of_the_Mouse_Pulmonary_System	Retired_Concepts	Miscellaneous Tumors of the Murine Pulmonary System|Miscellaneous Tumors of the Pulmonary System
C23006	Lymphoproliferative_Tumors_of_the_Mouse_Pulmonary_System	Retired_Concepts	Lymphoproliferative Tumors of the Murine Pulmonary System|Lymphoproliferative Tumors of the Pulmonary System
C23007	Secondary_Tumors_of_the_Murine_Pulmonary_System	Retired_Concepts	Secondary Tumors of the Murine Pulmonary System|Secondary Tumors of the Pulmonary System
C23008	Unclassified_Tumors_of_the_Mouse_Pulmonary_System	Retired_Concepts	Unclassified Tumors of the Murine Pulmonary System|Unclassified Tumors of the Pulmonary System
C23009	Tumor-Like_Diseases_of_the_Mouse_Pulmonary_System	Retired_Concepts	Tumor-Like Diseases of the Murine Pulmonary System|Tumor-Like Diseases of the Pulmonary System
C23010	Staining_Methods	Histological_Techniques	Staining Method|Staining|Staining Methods	Any of the various methods that use a dye, reagent, or other material for producing coloration in tissues or microorganisms for microscopic examination.
C23011	Hematoxylin_and_Eosin_Staining_Method	Routine_Histology_Staining_Method	Hematoxylin and Eosin Staining Method|H and E|HE|Hematoxylin and Eosin	Hematoxylin-and-eosin, or H&E, is a routine staining procedure of tissue sections. This staining method uses two separate dyes, one staining the nucleus and the other staining the cytoplasm and connective tissue. Hematoxylin is a dark purplish dye that stains the chromatin (nuclear material) within the nucleus. Eosin is an orangish-pink to red dye that stains the cytoplasmic material including connective tissue and collagen.(NCI2005)
C23012	Trichrome_Staining_Method	Special_Histology_Staining_Method	Trichrome Staining Method|TRIC|Trichrome	Masson trichrome, a mixture of three dyes, is used to differentiate between collagen and smooth muscle in tumors, and increases in collagen in cirrhosis. The three dyes used are aniline blue that stains collagen and mucus to blue or blue green, the cytoplasm and muscle and keratin are stained red by Beibrich Scarlet and nuclei are stained blue to black with Weigert's Iron hematoxylin (From BioGenex).
C23013	Elastin_Staining_Method	Special_Histology_Staining_Method	Elastin Staining Method|ELAS|Elastin	An immunohistochemical technique to detect elastin, a polymeric protein found in the connective tissue that imparts the property of elasticity to vertebrate elastic tissue. (NCI2005)
C23014	Gram_Staining_Method	Special_Histology_Staining_Method	Gram Staining Method|GRAM|Gram Stain	This is a method (named after the Danish bacteriologist, Hans Christian Gram) for staining and identifying bacteria. It is based on the differential retention of a crystal violet-iodine complex within the cell membrane. Gram-positive organisms will appear blue-black or purple while Gram-negative organisms will appear red.(NCI2005)
C23015	Acid_Fast_Bacillae_Staining_Method	Special_Histology_Staining_Method	Acid Fast Bacillae Staining Method|AFB|Acid Fast|Acid Fast Bacillae	The acid-fast stain is a test used to examine a specimen for the presence of acid-fast microorganisms, specifically mycobacteria, which include the bacteria that cause tuberculosis. Acid-fast bacteria resist decoloration with acid-alcohol and stain red, while other bacteria in the specimen will stain blue.
C23016	Iron_Staining_Method	Special_Histology_Staining_Method	Iron Staining Method|Iron	Iron stain is the classic method for demonstrating iron in tissues. Hemosiderin (storage iron granules) may be present in areas of old hemorrhage or be deposited in tissues with iron overload. Prussian blue stain is used for the demonstration of ferric iron in the tissue sections. This stain can aid in identifying hemochromatosis and hemosederosis where abnormal large deposits of iron may be seen. In the prussian blue staining, the sections are treated with an acidic solution of potassium ferrocyanide and any ferric iron present reacts to form an insoluble bright blue pigment called Prussian blue.(NCI2005)
C23017	Methyl_Green_Pyronine_Staining_Method	Special_Histology_Staining_Method	Methyl Green Pyronine Staining Method|MGP|Methyl Green Pyronine	A histological procedure, which is used for localization of RNA and DNA. Methyl green is a cation, which binds rather specifically to DNA and thus serves as a convenient means of staining nuclei in both fixed material and living cells. Pyronin, a red dye, is fairly specific for RNA with some binding to protein. (NCI2005)
C23018	Silver_Staining_Method	Special_Histology_Staining_Method	Silver Staining Method|SILV|Silver	Silver Staining or GMS staining is a technique for demonstrating fungi in tissue sections. It is primarily based on staining the polysaccharides in fungal cell wall (From BioGenex).
C23019	Periodic_Acid_Schiff_Staining_Method	Special_Histology_Staining_Method	Periodic Acid Schiff Staining Method|PAS|Periodic Acid Schiff	This is an all-round useful stain for many things, including glycogen, mucin, mucoprotein, glycoprotein, as well as fungi. The reaction is based on the oxidation of glycol group to aldehydes by periodate. The schiff's reagent selectively stains the aldehydes to a rose pink color. PAS is useful for outlining tissue structures--basement membranes, capsules, blood vessels, etc. (NCI2005)
C23020	Immunohistochemistry_Staining_Method	Special_Histology_Staining_Method	Immunohistochemistry Staining Method|IHC|Immunohistochemistry	Immunohistochemical staining techniques allow for the visualization of antigens via the sequential application of a specific antibody to the antigen (primary antibody), a secondary antibody to the primary antibody and an enzyme complex with a chromogenic substrate. The enzymatic activation of the chromogen results in a visible reaction product at the antigen site. The specimen may then be counterstained and coverslipped. Results are interpreted using a light microscope and aid in the differential diagnosis of pathophysiological processes, which may or may not be associated with a particular antigen.(NCI2005)
C23021	Smooth_Muscle_Actin_Staining_Method	Special_Histology_Staining_Method	Smooth Muscle Actin Staining Method|SMA|Smooth Muscle Actin	An immunohistochemical staining protocol for localization of actin. The antibody is specific for the alpha-smooth muscle actin present in smooth muscle cells.(NCI2005)
C23022	in_situ_Hybridization_Staining_Method	Special_Histology_Staining_Method	in situ Hybridization Staining Method|ISH|In Situ Hybridization|In Situ Hybridization Staining Method	In Situ Hybridization staining is an immunohistochemistry staining procedure which allows the demonstration of specific nucleic acid sequences (genes) in their cellular environment. The DNA sequence in the host cell is detected by hybridization with a biotin-labeled cDNA probe. Used for detecting protein and gene expression, determining tissue specificity, and localizing genes and proteins within tissue samples.(NCI2005)
C23023	E-Cadherin_Staining_Method	Special_Histology_Staining_Method	E-Cadherin Staining Method|ECAD|Ecadherin|Ecadherin Staining Method	An immunohistochemical technique to detect E-Cadherin, a transmembrane glycoprotein that is localized in the adherens junctions of epithelial cells, using antibody to E-Cadherin . The loss of expression or function of E-Cadherin appears to be an important step in tumorigenic progression.(NCI2005)
C23024	Beta_Catenin_Staining_Method	Special_Histology_Staining_Method	Beta Catenin Staining Method|BCAT|Beta Catenin	Beta Catenin Staining Method is an immunohistochemical technique that uses anti-beta-catenin monoclonal antibody and subsequent staining by the avidin-biotin to immunostain beta-catenin. This technique is useful in detection of colorectal cancer, where beta-catenin is accumulated as a result of APC mutations.
C23025	Cytokeratin-14_Staining_Method	Special_Histology_Staining_Method	Cytokeratin-14 Staining Method|CK14|Cytokeratin 14|Cytokeratin 14 Staining Method	An immunohistochemical technique to detect cytokeratin14,an intermediate filament protein, using monoclonal antibody to cytokeratin 14. The technique is used in diagnostic histopathology to identify early squamous metaplasia.
C23026	Cytokeratin-8_Staining_Method	Special_Histology_Staining_Method	Cytokeratin-8 Staining Method|CK8|Cytokeratin 8|Cytokeratin 8 Staining Method	An immunohistochemical technique to detect cytokeratin 8, an intermediate filament protein, using monoclonal antibody to cytokeratin 8. The antibody is useful in the detection of adenocarcinomas, mesotheliomas, and certain squamous epithelia-derived carcinomas. Specific combinations of cytokeratin peptides are associated with certain epithelial cells, and are therefore useful in the characterization of poorly differentiated carcinoma. The test is used as a clinically significant indicator in distinguishing carcinoma from malignant tumors of non-epithelial origin, such as lymphoma, sarcoma, and melanoma.
C23027	Cytokeratin-18_Staining_Method	Special_Histology_Staining_Method	Cytokeratin-18 Staining Method|CK18|Cytokeratin 18|Cytokeratin 18 Staining Method	An immunohistochemical technique to detect cytokeratin 18, an intermediate filament protein, using monoclonal antibody to cytokeratin 18. Specific combinations of cytokeratin peptides are associated with certain epithelial cells, and are therefore useful in the characterization of poorly differentiated carcinoma. The antibody reacts with a large number of epithelial cell types including many ductal and glandular epithelia. The test is used as a clinically significant indicator in distinguishing carcinoma from malignant tumors of non-epithelial origin, such as lymphoma, sarcoma, and melanoma.
C23028	Laminin_Staining_Method	Special_Histology_Staining_Method	Laminin Staining Method|LAM|Laminin	This immunohistochemical technique is used to detect laminin, a large extracellular matrix glycoprotein, using antibody directed towards laminin. This may be useful as a marker for basement membrane integrity. (NCI2005)
C23029	Synaptophysin_Staining_Method	Special_Histology_Staining_Method	Synaptophysin Staining Method|SYNP|Synaptophysin	This is an immunohistochemical technique utilizing antibody to synaptophysin, an integral membrane glycoprotein present in presynaptic vesicles in neurons. The antibody labels neuroendocrine cells and neurons of the brain, spinal cord and retina. Used to detect neuroendrocrine neoplasms including neuroblastomas, ganglioneuroblastomas, ganglioneuromas, pheochromocytomas, chromaffin, and non-chromaffin paragangliomas.(NCI2005)
C23030	Whey_Acidic_Protein_Staining_Method	Special_Histology_Staining_Method	Whey Acidic Protein Staining Method|WAP|Whey Acidic Protein	An immunohistochemical technique to identify whey acidic protein (WAP), a major whey protein secreted in rodent's milk. WAP promoter has been used for targeting heterologous genes to the mammary gland. The technique is used in diagnostic histopathology to identify breast cancer.(NCI2005)
C23031	Osteopontin_Staining_Method	Special_Histology_Staining_Method	Osteopontin Staining Method|OPN|Osteopontin	An immunohistochemical procedure for identification of osteopontin, a highly phosphorylated, calcium binding sialoprotein. Elevation in osteopontin levels are seen during sepsis and metastatic cancers. It is used as a tumor marker. (NCI2005)
C23032	Mucin-1_Staining_Method	Special_Histology_Staining_Method	Mucin-1 Staining Method|MUC1|Mucin 1|Mucin 1 Staining Method	An immunohistochemical technique used to detect the gene product of the MUC1 gene, using monoclonal antibodies directed against mucin-1 glycoprotein. (NCI2005)
C23033	Mucin-2_Staining_Method	Special_Histology_Staining_Method	Mucin-2 Staining Method|MUC2|Mucin 2|Mucin 2 Staining Method	An immunohistochemical technique used to detect the gene product of the MUC2 gene, using monoclonal antibodies directed against mucin-2 glycoprotein. (NCI2005)
C23034	Polyoma_Virus_Middle_T_Staining_Method	Special_Histology_Staining_Method	Polyoma Virus Middle T Staining Method|PYMT|Polyoma Virus Middle T	Polyoma virus encodes three proteins, the large T (PyLT), middle T (PymT), and small T (Pyst) antigens, that bind p53 and thus block the function of p53. This immunohistochemical technique is used to identify metastasis-related genes using antibodies directed at Polyoma Virus Middle T antigen. (NCI2005)
C23035	c-Myc_Staining_Method	Special_Histology_Staining_Method	c-Myc Staining Method|Cmyc Staining Method|MYC|cmyc	c-Myc staining is a sensitive immunohistochemical method for studying the tissue localization of c-Myc protein using antibody followed by a microscopic observation of the c-Myc staining distribution. The technique is used to detect overexpression of c-Myc oncogene which leads to  cancer.
C23036	Her2_erbb2_neu_Staining_Method	Special_Histology_Staining_Method	Her2/erbb2/neu Staining Method|ERBB|her2/erbb2/neu	A immunohistochemical technique to identify ErbB2/Neu gene, which encodes for 185-kDa member of the ErbB family of cell surface receptor tyrosine kinases. This family of growth factor receptors is comprised of four members: epidermal growth factor receptor (also termed ErbB1/HER1), ErbB2/Neu/HER2/p185, ErbB3/HER3, and ErbB4/HER4. Activation of the ErbB family of growth factor receptors and subsequent stimulation of their associated intracellular signaling pathways is a significant factor in the genesis of several human cancers. The technique is used in diagnostic histopathology to identify breast cancer. (NCI2005)
C23037	Neu_Staining_Method	Special_Histology_Staining_Method	Neu Staining Method|CNEU|neu
C23038	Staining_for_Viral_Inclusions	Special_Histology_Staining_Method	Staining for Viral Inclusions|Stain for Viral Inclusions	A staining procedure to detect viral inclusion bodies, which are virus particles inside host cells. Orcein stains are used to detect the inclusion bodies, giving a "ground glass" appearance, and are visible with light microscopy.(NCI2005)
C23039	Staining_of_Sputum_for_Pneumocystis	Special_Histology_Staining_Method	Staining of Sputum for Pneumocystis	A simple and noninvasive procedure for Pneumocystis carinii pneumonia (PCP) diagnosis, in which the specimen used is induced sputum. The specimen is stained with either Giemsa, silver stain or toluidine blue. Alternatively, an indirect immunofluorescent stain using monoclonal antibodies can be used.(NCI2005)
C23040	Warthin-Starry_Staining_Method	Special_Histology_Staining_Method	Warthin-Starry Staining Method|Warthin-Starry Staining	A histopathological technique for staining spirochetes and other microorganisms. Commonly used for identification of Helicobacter pylori in gastritis and peptic ulcer disease.(NCI2005)
C23041	Wright-Giemsa_Staining_Method	Special_Histology_Staining_Method	Wright-Giemsa Staining Method|Wright-Giemsa Staining	Geimsa is a polychromatic stain that permits the differentiation of cells present in hematopoietic tissues and for the demonstration of certain microorganisms. It is used for the detection of helicobacter Pylori. The H. Pylori and nuclei stain dark blue and cytoplasm stain pink with this stain (From BioGenex).
C23042	Diff-Quik_Staining_Method	Special_Histology_Staining_Method	Diff-Quik Staining Method|Diff-quik Stain|Diff-quik Staining Method	Diff-Quick is an alcoholic, quick staining method for cytology. It consists of two solutions: an eosinophilic (red) solution and a basophilic (blue) stain. It is used for identifying squamous epithelial cells, inflammatory cells, yeast, bacteria, etc. (NCI2005)
C23043	Routine_Histology_Staining_Method	Staining_Methods	Routine Histology Staining Method|Routine Histology Stains	"Routine" histology staining generally refers to staining performed using hematoxylin and eosin. Hematoxylin stains the nuclei in cells and other cationic elements purple. Eosin is an anionic dye and binds to cytoplasmic proteins below pH6 giving a pink color. (From Biogenex)
C23044	Special_Histology_Staining_Method	Staining_Methods	Special Histology Staining Method|Special Histology Stains	Histological technique in which special stains are used to visualize specific tissue and cellular structures. These are dyes that bind to the cellular components either physically or by chemical bonds. (From Biogenex).
C23045	Mouse_Head_and_Neck_Neoplasms	Mouse_Head_and_Neck_Disorder|Mouse_Neoplasms_by_Location	Mouse Head and Neck Neoplasms|Head and Neck Neoplasms
C23046	Mouse_Oral_Cavity_Neoplasms	Mouse_Digestive_System_Neoplasms|Mouse_Head_and_Neck_Neoplasms	Mouse Oral Cavity Neoplasms|Oral Cavity Neoplasms
C23047	Epithelial_Neoplasms_of_the_Mouse_Oral_Cavity	Mouse_Oral_Cavity_Neoplasms	Epithelial Neoplasms of the Mouse Oral Cavity|Epithelial Neoplasms of the Oral Cavity
C23048	Carcinoma_of_the_Mouse_Oral_Cavity	Epithelial_Neoplasms_of_the_Mouse_Oral_Cavity	Carcinoma of the Mouse Oral Cavity|Carcinoma of the Oral Cavity
C23049	Squamous_Cell_Carcinoma_of_the_Mouse_Oral_Cavity	Carcinoma_of_the_Mouse_Oral_Cavity	Squamous Cell Carcinoma of the Mouse Oral Cavity|Squamous Cell Carcinoma of the Oral Cavity
C23050	Squamous_Cell_Carcinoma_In-situ_of_the_Mouse_Oral_Cavity	Squamous_Cell_Carcinoma_of_the_Mouse_Oral_Cavity	Squamous Cell Carcinoma In-situ of the Mouse Oral Cavity|Squamous Cell Carcinoma In-situ of the Oral Cavity
C23051	Verrucous_Carcinoma_of_the_Mouse_Oral_Cavity	Squamous_Cell_Carcinoma_of_the_Mouse_Oral_Cavity	Verrucous Carcinoma of the Mouse Oral Cavity|Verrucous Carcinoma of the Oral Cavity
C23052	Adenosquamous_Cell_Carcinoma_of_the_Mouse_Oral_Cavity	Carcinoma_of_the_Mouse_Oral_Cavity|Mouse_Adenosquamous_Carcinoma	Adenosquamous Cell Carcinoma of the Mouse Oral Cavity|Adenosquamous Cell Carcinoma of the Oral Cavity
C23053	Smooth_Muscle_Neoplasms_of_the_Mouse_Oral_Cavity	Mouse_Oral_Cavity_Neoplasms	Smooth Muscle Neoplasms of the Mouse Oral Cavity|Smooth Muscle Neoplasms of the Oral Cavity
C23054	Leiomyoma_of_the_Mouse_Oral_Cavity	Mouse_Leiomyoma|Smooth_Muscle_Neoplasms_of_the_Mouse_Oral_Cavity	Leiomyoma of the Mouse Oral Cavity|Leiomyoma of the Oral Cavity
C23055	Leiomyosarcoma_of_the_Mouse_Oral_Cavity	Mouse_Leiomyosarcoma|Smooth_Muscle_Neoplasms_of_the_Mouse_Oral_Cavity	Leiomyosarcoma of the Mouse Oral Cavity|Leiomyosarcoma of the Oral Cavity
C23056	Neural_Neoplasms_of_the_Mouse_Oral_Cavity	Mouse_Oral_Cavity_Neoplasms	Neural Neoplasms of the Mouse Oral Cavity|Neural Neoplasms of the Oral Cavity
C23057	Neurilemoma_of_the_Mouse_Oral_Cavity	Neural_Neoplasms_of_the_Mouse_Oral_Cavity	Neurilemoma of the Mouse Oral Cavity|Neurilemoma of the Oral Cavity
C23058	Neurofibroma_of_the_Mouse_Oral_Cavity	Mouse_Neurofibroma|Neural_Neoplasms_of_the_Mouse_Oral_Cavity	Neurofibroma of the Mouse Oral Cavity|Neurofibroma of the Oral Cavity
C23059	Synovial_Neoplasms_of_the_Mouse_Oral_Cavity	Mouse_Oral_Cavity_Neoplasms	Synovial Neoplasms of the Mouse Oral Cavity|Synovial Neoplasms of the Oral Cavity
C23060	Synovial_Sarcoma_of_the_Mouse_Oral_Cavity	Mouse_Synovial_Sarcoma|Synovial_Neoplasms_of_the_Mouse_Oral_Cavity	Synovial Sarcoma of the Mouse Oral Cavity|Synovial Sarcoma of the Oral Cavity
C23061	Melanocytic_Neoplasms_of_the_Mouse_Oral_Cavity	Mouse_Oral_Cavity_Neoplasms	Melanocytic Neoplasms of the Mouse Oral Cavity|Melanocytic Neoplasms of the Oral Cavity
C23062	Melanoma_of_the_Mouse_Oral_Cavity	Melanocytic_Neoplasms_of_the_Mouse_Oral_Cavity	Melanoma of the Mouse Oral Cavity|Melanoma of the Oral Cavity
C23063	Hematopoietic_Neoplasms_of_the_Mouse_Oral_Cavity	Mouse_Oral_Cavity_Neoplasms	Hematopoietic Neoplasms of the Mouse Oral Cavity|Hematopoietic Neoplasms of the Oral Cavity
C23064	Lymphoproliferative_Neoplasms_of_the_Mouse_Oral_Cavity	Hematopoietic_Neoplasms_of_the_Mouse_Oral_Cavity	Lymphoproliferative Neoplasms of the Mouse Oral Cavity|Lymphoproliferative Neoplasms of the Oral Cavity
C23065	Lymphoma_of_the_Mouse_Oral_Cavity	Lymphoproliferative_Neoplasms_of_the_Mouse_Oral_Cavity|Mouse_Lymphoma	Lymphoma of the Mouse Oral Cavity|Lymphoma of the Oral Cavity
C23066	Plasma_Cell_Neoplasms_of_the_Mouse_Oral_Cavity	Hematopoietic_Neoplasms_of_the_Mouse_Oral_Cavity	Plasma Cell Neoplasms of the Mouse Oral Cavity|Plasma Cell Neoplasms of the Oral Cavity
C23067	Plasmacytoma_of_the_Mouse_Oral_Cavity	Plasma_Cell_Neoplasms_of_the_Mouse_Oral_Cavity	Plasmacytoma of the Mouse Oral Cavity|Plasmacytoma of the Oral Cavity
C23068	Mouse_Pharyngeal_Neoplasms	Mouse_Digestive_System_Neoplasms|Mouse_Head_and_Neck_Neoplasms	Mouse Pharyngeal Neoplasms|Pharyngeal Neoplasms
C23069	Epithelial_Neoplasms_of_the_Mouse_Pharynx	Mouse_Pharyngeal_Neoplasms	Epithelial Neoplasms of the Mouse Pharynx|Epithelial Neoplasms of the Pharynx
C23070	Squamous_Cell_Carcinoma_of_the_Mouse_Pharynx	Epithelial_Neoplasms_of_the_Mouse_Pharynx|Mouse_Squamous_Cell_Carcinoma	Squamous Cell Carcinoma of the Mouse Pharynx|Squamous Cell Carcinoma of the Pharynx
C23071	Non-Keratinizing_Carcinoma_of_the_Mouse_Pharynx	Epithelial_Neoplasms_of_the_Mouse_Pharynx	Non-Keratinizing Carcinoma of the Mouse Pharynx|Non-keratinizing Carcinoma of the Mouse Pharynx|Non-keratinizing Carcinoma of the Pharynx
C23072	Non-Keratinizing_Carcinoma_of_the_Mouse_Pharynx_Without_Lymphoid_Stroma	Non-Keratinizing_Carcinoma_of_the_Mouse_Pharynx	Non-Keratinizing Carcinoma of the Mouse Pharynx Without Lymphoid Stroma|Non-keratinizing Carcinoma of the Mouse Pharynx Without Lymphoid Stroma|Non-keratinizing Carcinoma of the Pharynx Without Lymphoid Stroma
C23073	Non-Keratinizing_Carcinoma_of_the_Mouse_Pharynx_With_Lymphoid_Stroma	Non-Keratinizing_Carcinoma_of_the_Mouse_Pharynx	Non-Keratinizing Carcinoma of the Mouse Pharynx With Lymphoid Stroma|Non-keratinizing Carcinoma of the Mouse Pharynx With Lymphoid Stroma|Non-keratinizing Carcinoma of the Pharynx With Lymphoid Stroma
C23074	Undifferentiated_Carcinoma_of_the_Mouse_Pharynx	Epithelial_Neoplasms_of_the_Mouse_Pharynx|Mouse_Undifferentiated_Carcinoma	Undifferentiated Carcinoma of the Mouse Pharynx|Undifferentiated Carcinoma of the Pharynx
C23075	Undifferentiated_Carcinoma_of_the_Mouse_Pharynx_Without_Lymphoid_Stroma	Undifferentiated_Carcinoma_of_the_Mouse_Pharynx	Undifferentiated Carcinoma of the Mouse Pharynx Without Lymphoid Stroma|Undifferentiated Carcinoma of the Pharynx Without Lymphoid Stroma
C23076	Undifferentiated_Carcinoma_of_the_Mouse_Pharynx_With_Lymphoid_Stroma	Undifferentiated_Carcinoma_of_the_Mouse_Pharynx	Undifferentiated Carcinoma of the Mouse Pharynx With Lymphoid Stroma|Undifferentiated Carcinoma of the Pharynx With Lymphoid Stroma
C23077	Skeletal_Muscle_Neoplasms_of_the_Mouse_Pharynx	Mouse_Pharyngeal_Neoplasms	Skeletal Muscle Neoplasms of the Mouse Pharynx|Skeletal Muscle Neoplasms of the Pharynx
C23078	Embryonal_Rhabdomyosarcoma_of_the_Mouse_Pharynx	Mouse_Rhabdomyosarcoma|Skeletal_Muscle_Neoplasms_of_the_Mouse_Pharynx	Embryonal Rhabdomyosarcoma of the Mouse Pharynx|Embryonal Rhabdomyosarcoma of the Pharynx
C23079	Synovial_Neoplasms_of_the_Mouse_Pharynx	Mouse_Pharyngeal_Neoplasms	Synovial Neoplasms of the Mouse Pharynx|Synovial Neoplasms of the Pharynx
C23080	Synovial_Sarcoma_of_the_Mouse_Pharynx	Synovial_Neoplasms_of_the_Mouse_Pharynx	Synovial Sarcoma of the Mouse Pharynx|Synovial Sarcoma of the Pharynx
C23081	Vascular-fibrous_Neoplasms_of_the_Mouse_Pharynx	Mouse_Pharyngeal_Neoplasms	Vascular-fibrous Neoplasms of the Mouse Pharynx|Vascular-fibrous Neoplasms of the Pharynx
C23082	Angiofibroma_of_the_Mouse_Pharynx	Vascular-fibrous_Neoplasms_of_the_Mouse_Pharynx	Angiofibroma of the Mouse Pharynx|Angiofibroma of the Pharynx
C23083	Hematopoietic_Neoplasms_of_the_Mouse_Pharynx	Mouse_Pharyngeal_Neoplasms	Hematopoietic Neoplasms of the Mouse Pharynx|Hematopoietic Neoplasms of the Pharynx
C23084	Lymphoproliferative_Neoplasms_of_the_Mouse_Pharynx	Hematopoietic_Neoplasms_of_the_Mouse_Pharynx	Lymphoproliferative Neoplasms of the Mouse Pharynx|Lymphoproliferative Neoplasms of the Pharynx
C23085	Lymphoma_of_the_Mouse_Pharynx	Lymphoproliferative_Neoplasms_of_the_Mouse_Pharynx|Mouse_Lymphoma	Lymphoma of the Mouse Pharynx|Lymphoma of the Pharynx
C23086	Plasma_Cell_Neoplasms_of_the_Mouse_Pharynx	Hematopoietic_Neoplasms_of_the_Mouse_Pharynx	Plasma Cell Neoplasms of the Mouse Pharynx|Plasma Cell Neoplasms of the Pharynx
C23087	Plasmacytoma_of_the_Mouse_Pharynx	B_Cell_Neoplasms_of_the_Mouse_Hematologic_System|Lymphoma_of_the_Mouse_Pharynx|Plasma_Cell_Neoplasms_of_the_Mouse_Pharynx	Plasmacytoma of the Mouse Pharynx|Plasmacytoma of the Pharynx
C23088	Mouse_Nose_and_Paranasal_Sinuses_Neoplasms	Mouse_Head_and_Neck_Neoplasms|Mouse_Special_Sense_Organ_Neoplasms	Mouse Nose and Paranasal Sinuses Neoplasms|Nose and Paranasal Sinuses Neoplasms
C23089	Epithelial_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Mouse_Nose_and_Paranasal_Sinuses_Neoplasms	Epithelial Neoplasms of the Mouse Nose and Paranasal Sinuses|Epithelial Neoplasms of the Nose and Paranasal Sinuses
C23090	Papilloma_of_the_Mouse_Nose_and_Paranasal_Sinuses	Epithelial_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Papilloma of the Mouse Nose and Paranasal Sinuses|Papilloma of the Nose and Paranasal Sinuses
C23091	Carcinoma_of_the_Mouse_Nose_and_Paranasal_Sinuses	Epithelial_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Carcinoma of the Mouse Nose and Paranasal Sinuses|Carcinoma of the Nose and Paranasal Sinuses
C23092	Squamous_Cell_Carcinoma_of_the_Mouse_Nose_and_Paranasal_Sinuses	Carcinoma_of_the_Mouse_Nose_and_Paranasal_Sinuses	Squamous Cell Carcinoma of the Mouse Nose and Paranasal Sinuses|Squamous Cell Carcinoma of the Nose and Paranasal Sinuses
C23093	Verrucous_Carcinoma_of_the_Mouse_Nose_and_Paranasal_Sinuses	Squamous_Cell_Carcinoma_of_the_Mouse_Nose_and_Paranasal_Sinuses	Verrucous Carcinoma of the Mouse Nose and Paranasal Sinuses|Verrucous Carcinoma of the Nose and Paranasal Sinuses
C23094	Adenocarcinoma_of_the_Mouse_Nose_and_Paranasal_Sinuses	Carcinoma_of_the_Mouse_Nose_and_Paranasal_Sinuses	Adenocarcinoma of the Mouse Nose and Paranasal Sinuses|Adenocarcinoma of the Nose and Paranasal Sinuses
C23095	Neural_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Mouse_Nose_and_Paranasal_Sinuses_Neoplasms	Neural Neoplasms of the Mouse Nose and Paranasal Sinuses|Neural Neoplasms of the Nose and Paranasal Sinuses
C23096	Olfactory_Neuroblastoma_of_the_Mouse_Nose_and_Paranasal_Sinuses	Mouse_Neuroblastic_Tumours|Neural_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Olfactory Neuroblastoma of the Mouse Nose and Paranasal Sinuses|Olfactory Neuroblastoma of the Nose and Paranasal Sinuses
C23097	Melanocytic_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Mouse_Nose_and_Paranasal_Sinuses_Neoplasms	Melanocytic Neoplasms of the Mouse Nose and Paranasal Sinuses|Melanocytic Neoplasms of the Nose and Paranasal Sinuses
C23098	Melanoma_of_the_Mouse_Nose_and_Paranasal_Sinuses	Melanocytic_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Melanoma of the Mouse Nose and Paranasal Sinuses|Melanoma of the Nose and Paranasal Sinuses
C23099	Hematopoietic_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Mouse_Nose_and_Paranasal_Sinuses_Neoplasms	Hematopoietic Neoplasms of the Mouse Nose and Paranasal Sinuses|Hematopoietic Neoplasms of the Nose and Paranasal Sinuses
C23100	Lymphoproliferative_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Hematopoietic_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Lymphoproliferative Neoplasms of the Mouse Nose and Paranasal Sinuses|Lymphoproliferative Neoplasms of the Nose and Paranasal Sinuses
C23101	Lymphoma_of_the_Mouse_Nose_and_Paranasal_Sinuses	Lymphoproliferative_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses|Mouse_Lymphoma	Lymphoma of the Mouse Nose and Paranasal Sinuses|Lymphoma of the Nose and Paranasal Sinuses
C23102	Angiocentric_Immunoproliferative_Lesion_of_the_Mouse_Nose_and_Paranasal_Sinuses	Lymphoma_of_the_Mouse_Nose_and_Paranasal_Sinuses	Angiocentric Immunoproliferative Lesion of the Mouse Nose and Paranasal Sinuses|Angiocentric Immunoproliferative Lesion of the Nose and Paranasal Sinuses
C23103	Plasma_Cell_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Hematopoietic_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Plasma Cell Neoplasms of the Mouse Nose and Paranasal Sinuses|Plasma Cell Neoplasms of the Nose and Paranasal Sinuses
C23104	Plasmacytoma_of_the_Mouse_Nose_and_Paranasal_Sinuses	Plasma_Cell_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Plasmacytoma of the Mouse Nose and Paranasal Sinuses|Plasmacytoma of the Nose and Paranasal Sinuses
C23105	Smooth_Muscle_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Mouse_Nose_and_Paranasal_Sinuses_Neoplasms	Smooth Muscle Neoplasms of the Mouse Nose and Paranasal Sinuses|Smooth Muscle Neoplasms of the Nose and Paranasal Sinuses
C23106	Leiomyosarcoma_of_the_Mouse_Nose_and_Paranasal_Sinuses	Mouse_Leiomyosarcoma|Smooth_Muscle_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Leiomyosarcoma of the Mouse Nose and Paranasal Sinuses|Leiomyosarcoma of the Nose and Paranasal Sinuses
C23107	Skeletal_Muscle_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Mouse_Nose_and_Paranasal_Sinuses_Neoplasms	Skeletal Muscle Neoplasms of the Mouse Nose and Paranasal Sinuses|Skeletal Muscle Neoplasms of the Nose and Paranasal Sinuses
C23108	Embryonal_Rhabdomyosarcoma_of_the_Mouse_Nose_and_Paranasal_Sinuses	Skeletal_Muscle_Neoplasms_of_the_Mouse_Nose_and_Paranasal_Sinuses	Embryonal Rhabdomyosarcoma of the Mouse Nose and Paranasal Sinuses|Embryonal Rhabdomyosarcoma of the Nose and Paranasal Sinuses
C23109	Mouse_Laryngeal_Neoplasms	Mouse_Head_and_Neck_Neoplasms	Mouse Laryngeal Neoplasms|Laryngeal Neoplasms
C23110	Epithelial_Neoplasms_of_the_Mouse_Larynx	Mouse_Laryngeal_Neoplasms	Epithelial Neoplasms of the Mouse Larynx|Epithelial Neoplasms of the Larynx
C23111	Papilloma_of_the_Mouse_Larynx	Epithelial_Neoplasms_of_the_Mouse_Larynx	Papilloma of the Mouse Larynx|Papilloma of the Larynx
C23112	Carcinoma_of_the_Mouse_Larynx	Epithelial_Neoplasms_of_the_Mouse_Larynx	Carcinoma of the Mouse Larynx|Carcinoma of the Larynx
C23113	Squamous_Cell_Carcinoma_of_the_Mouse_Larynx	Carcinoma_of_the_Mouse_Larynx|Mouse_Squamous_Cell_Carcinoma	Squamous Cell Carcinoma of the Mouse Larynx|Squamous Cell Carcinoma of the Larynx
C23114	Squamous_Cell_Carcinoma_In-situ_of_the_Mouse_Larynx	Squamous_Cell_Carcinoma_of_the_Mouse_Larynx	Squamous Cell Carcinoma In-situ of the Mouse Larynx|Squamous Cell Carcinoma In-situ of the Larynx
C23115	Adenoid_Cystic_Carcinoma_of_the_Mouse_Larynx	Carcinoma_of_the_Mouse_Larynx	Adenoid Cystic Carcinoma of the Mouse Larynx|Adenoid Cystic Carcinoma of the Larynx
C23116	Mucoepidermoid_Carcinoma_of_the_Mouse_Larynx	Carcinoma_of_the_Mouse_Larynx	Mucoepidermoid Carcinoma of the Mouse Larynx|Mucoepidermoid Carcinoma of the Larynx
C23117	Acinic_Cell_Carcinoma_of_the_Mouse_Larynx	Carcinoma_of_the_Mouse_Larynx|Mouse_Acinar_Cell_Neoplasm	Acinic Cell Carcinoma of the Mouse Larynx|Acinic Cell Carcinoma of the Larynx
C23118	Cartilage_Bone_Neoplasms_of_the_Mouse_Larynx	Mouse_Laryngeal_Neoplasms	Cartilage/Bone Neoplasms of the Mouse Larynx|Cartilage/Bone Neoplasms of the Larynx
C23119	Chondrosarcoma_of_the_Mouse_Larynx	Cartilage_Bone_Neoplasms_of_the_Mouse_Larynx|Mouse_Chondrosarcoma	Chondrosarcoma of the Mouse Larynx|Chondrosarcoma of the Larynx
C23120	Osteosarcoma_of_the_Mouse_Larynx	Cartilage_Bone_Neoplasms_of_the_Mouse_Larynx|Mouse_Osteosarcoma	Osteosarcoma of the Mouse Larynx|Osteosarcoma of the Larynx
C23121	Histiocytic_Neoplasms_of_the_Mouse_Larynx	Mouse_Laryngeal_Neoplasms	Histiocytic Neoplasms of the Mouse Larynx|Histiocytic Neoplasms of the Larynx
C23122	Malignant_Fibrous_Histiocytoma_of_the_Mouse_Larynx	Histiocytic_Neoplasms_of_the_Mouse_Larynx|Mouse_Malignant_Mesenchymal_Neoplasm	Malignant Fibrous Histiocytoma of the Mouse Larynx|Malignant Fibrous Histiocytoma of the Larynx
C23123	Neuroendocrine_Neoplasms_of_the_Mouse_Larynx	Mouse_Laryngeal_Neoplasms	Neuroendocrine Neoplasms of the Mouse Larynx|Neuroendocrine Neoplasms of the Larynx
C23124	Carcinoid_Tumor_of_the_Mouse_Larynx	Mouse_Carcinoid_Tumor|Neuroendocrine_Neoplasms_of_the_Mouse_Larynx	Carcinoid Tumor of the Mouse Larynx|Carcinoid Tumor of the Larynx
C23125	Mouse_Salivary_Gland_Neoplasms	Mouse_Digestive_System_Neoplasms|Mouse_Head_and_Neck_Neoplasms	Mouse Salivary Gland Neoplasms|Salivary Gland Neoplasms
C23126	Epithelial_Neoplasms_of_the_Mouse_Salivary_Glands	Mouse_Salivary_Gland_Neoplasms	Epithelial Neoplasms of the Mouse Salivary Glands|Epithelial Neoplasms of the Salivary Glands
C23127	Adenoma_of_the_Mouse_Salivary_Glands	Epithelial_Neoplasms_of_the_Mouse_Salivary_Glands	Adenoma of the Mouse Salivary Glands|Adenoma of the Salivary Glands
C23128	Pleomorphic_Adenoma_of_the_Mouse_Salivary_Glands	Adenoma_of_the_Mouse_Salivary_Glands	Pleomorphic Adenoma of the Mouse Salivary Glands|Pleomorphic Adenoma of the Salivary Glands
C23129	Carcinoma_In_Pleomorphic_Adenoma_of_the_Mouse_Salivary_Glands	Pleomorphic_Adenoma_of_the_Mouse_Salivary_Glands	Carcinoma In Pleomorphic Adenoma of the Mouse Salivary Glands|Carcinoma In Pleomorphic Adenoma of the Salivary Glands
C23130	Monomorphic_Adenoma_of_the_Mouse_Salivary_Glands	Adenoma_of_the_Mouse_Salivary_Glands	Monomorphic Adenoma of the Mouse Salivary Glands|Monomorphic Adenoma of the Salivary Glands
C23131	Oxyphilic_Adenoma_of_the_Mouse_Salivary_Glands	Monomorphic_Adenoma_of_the_Mouse_Salivary_Glands	Oxyphilic Adenoma of the Mouse Salivary Glands|Oncocytoma|Oxyphilic Adenoma of the Salivary Glands
C23132	Warthin_s_Tumor_of_the_Mouse_Salivary_Glands	Monomorphic_Adenoma_of_the_Mouse_Salivary_Glands	Warthin's Tumor of the Mouse Salivary Glands|Papillary CystadenomaLymphomatosum|Warthin's Tumor of the Salivary Glands
C23133	Basal_Cell_Adenoma_of_the_Mouse_Salivary_Glands	Monomorphic_Adenoma_of_the_Mouse_Salivary_Glands	Basal Cell Adenoma of the Mouse Salivary Glands|Basal Cell Adenoma of the Salivary Glands
C23134	Clear_Cell_Adenoma_of_the_Mouse_Salivary_Glands	Monomorphic_Adenoma_of_the_Mouse_Salivary_Glands	Clear Cell Adenoma of the Mouse Salivary Glands|Clear Cell Adenoma of the Salivary Glands
C23135	Sebaceous_Lymphadenoma_of_the_Mouse_Salivary_Glands	Monomorphic_Adenoma_of_the_Mouse_Salivary_Glands	Sebaceous Lymphadenoma of the Mouse Salivary Glands|Sebaceous Lymphadenoma of the Salivary Glands
C23136	Myoepithelioma_of_the_Mouse_Salivary_Glands	Adenoma_of_the_Mouse_Salivary_Glands	Myoepithelioma of the Mouse Salivary Glands|Myoepithelioma of the Salivary Glands
C23137	Mucoepidermoid_Tumor_of_the_Mouse_Salivary_Glands	Adenoma_of_the_Mouse_Salivary_Glands	Mucoepidermoid Tumor of the Mouse Salivary Glands|Mucoepidermoid Tumor of the Salivary Glands
C23138	Low_Grade_Mucoepidermoid_Tumor_of_the_Mouse_Salivary_Glands	Mucoepidermoid_Tumor_of_the_Mouse_Salivary_Glands	Low Grade Mucoepidermoid Tumor of the Mouse Salivary Glands|Low Grade Mucoepidermoid Tumor of the Salivary Glands
C23139	High_Grade_Mucoepidermoid_Tumor_of_the_Mouse_Salivary_Glands	Mucoepidermoid_Tumor_of_the_Mouse_Salivary_Glands	High Grade Mucoepidermoid Tumor of the Mouse Salivary Glands|High Grade Mucoepidermoid Tumor of the Salivary Glands
C23140	Carcinoma_of_the_Mouse_Salivary_Glands	Epithelial_Neoplasms_of_the_Mouse_Salivary_Glands	Carcinoma of the Mouse Salivary Glands|Carcinoma of the Salivary Glands
C23141	Acinic_Cell_Carcinoma_of_the_Mouse_Salivary_Glands	Carcinoma_of_the_Mouse_Salivary_Glands	Acinic Cell Carcinoma of the Mouse Salivary Glands|Acinic Cell Carcinoma of the Salivary Glands
C23142	Adenoid_Cystic_Carcinoma_of_the_Mouse_Salivary_Glands	Carcinoma_of_the_Mouse_Salivary_Glands	Adenoid Cystic Carcinoma of the Mouse Salivary Glands|Adenoid Cystic Carcinoma of the Salivary Glands
C23143	Papillary_Adenocarcinoma_of_the_Mouse_Salivary_Glands	Carcinoma_of_the_Mouse_Salivary_Glands	Papillary Adenocarcinoma of the Mouse Salivary Glands|Papillary Adenocarcinoma of the Salivary Glands
C23144	Squamous_Cell_Carcinoma_of_the_Mouse_Salivary_Glands	Carcinoma_of_the_Mouse_Salivary_Glands	Squamous Cell Carcinoma of the Mouse Salivary Glands|Squamous Cell Carcinoma of the Salivary Glands
C23145	Adenocarcinoma_of_the_Mouse_Salivary_Glands	Carcinoma_of_the_Mouse_Salivary_Glands	Adenocarcinoma of the Mouse Salivary Glands|Adenocarcinoma of the Salivary Glands
C23146	Metastatic_Carcinoma_of_the_Mouse_Salivary_Glands	Carcinoma_of_the_Mouse_Salivary_Glands	Metastatic Carcinoma of the Mouse Salivary Glands|Metastatic Carcinoma of the Salivary Glands
C23147	Hematopoietic_Neoplasms_of_the_Mouse_Salivary_Glands	Mouse_Salivary_Gland_Neoplasms	Hematopoietic Neoplasms of the Mouse Salivary Glands|Hematopoietic Neoplasms of the Salivary Glands
C23148	Lymphoproliferative_Neoplasms_of_the_Mouse_Salivary_Glands	Mouse_Salivary_Gland_Neoplasms	Lymphoproliferative Neoplasms of the Mouse Salivary Glands|Lymphoproliferative Neoplasms of the Salivary Glands
C23149	Lymphoma_of_the_Mouse_Salivary_Glands	Lymphoproliferative_Neoplasms_of_the_Mouse_Salivary_Glands|Mouse_Lymphoma	Lymphoma of the Mouse Salivary Glands|Lymphoma of the Salivary Glands
C23150	Plasma_Cell_Neoplasms_of_the_Mouse_Salivary_Glands	Mouse_Salivary_Gland_Neoplasms	Plasma Cell Neoplasms of the Mouse Salivary Glands|Plasma Cell Neoplasms of the Salivary Glands
C23151	Plasmacytoma_of_the_Mouse_Salivary_Glands	Plasma_Cell_Neoplasms_of_the_Mouse_Salivary_Glands	Plasmacytoma of the Mouse Salivary Glands|Plasmacytoma of the Salivary Glands
C23152	Mouse_Anatomical_Concepts	Retired_Concepts	Murine Anatomical Concepts|Anatomical Concepts
C23153	Mouse_Lip	Retired_Concepts	Murine Lip|Lip|Lip, NOS	Either of the two fleshy, full-blooded margins of the mouth.
C23154	Mouse_External_Upper_Lip	Retired_Concepts	Murine External Upper Lip|External Upper Lip
C23155	Mouse_External_Lower_Lip	Retired_Concepts	Murine External Lower Lip|External Lower Lip
C23156	Mouse_External_Lip_NOS	Retired_Concepts	Murine External Lip, NOS|External Lip, NOS
C23157	Mouse_Mucosa_of_Upper_Lip	Retired_Concepts	Murine Mucosa of Upper Lip|Mucosa of Upper Lip
C23158	Mouse_Mucosa_of_Lower_Lip	Retired_Concepts	Murine Mucosa of Lower Lip|Mucosa of Lower Lip
C23159	Mouse_Mucosa_of_Lip_NOS	Retired_Concepts	Murine Mucosa of Lip, NOS|Mucosa of Lip, NOS
C23160	Mouse_Commissure_of_Lip	Retired_Concepts	Murine Commissure of Lip|Commissure of Lip
C23161	Mouse_Base_of_Tongue	Retired_Concepts	Murine Base of Tongue|BASE OF TONGUE|Base of Tongue|Base of tongue, NOS
C23162	Mouse_Palate	Retired_Concepts	Murine Palate|PALATE|Palate|Palate, NOS	The anteriorly located rigid section of the PALATE.
C23163	Mouse_Hard_Palate	Retired_Concepts	Murine Hard Palate|Hard Palate|Hard palate	The anteriorly located rigid section of the PALATE.
C23164	Mouse_Soft_Palate	Retired_Concepts	Murine Soft Palate|Soft Palate|Soft palate, NOS	A movable fold suspended from the posterior border of the hard palate. The uvula hangs from the middle of the lower border.
C23165	Mouse_Uvula	Retired_Concepts	Murine Uvula|Uvula
C23166	Mouse_Submandibular_Gland	Retired_Concepts	Murine Submandibular Gland|Submandibular Gland	One of two salivary glands in the neck, located in the space bound by the two bellies of the digastric muscle and the angle of the mandible. It discharges through the submandibular duct. The secretory units are predominantly serous although a few mucous alveoli, some with serous demilunes, occur. (Stedman, 25th ed)
C23167	Mouse_Sublingual_Gland	Retired_Concepts	Murine Sublingual Gland|Sublingual Gland
C23168	Mouse_Tonsillar_Fossa	Retired_Concepts	Murine Tonsillar Fossa|Tonsillar Fossa
C23169	Mouse_Tonsillar_Pillar	Retired_Concepts	Murine Tonsillar Pillar|Tonsillar Pillar
C23170	Mouse_Vallecula	Retired_Concepts	Murine Vallecula|Vallecula
C23171	Mouse_Anterior_Surface_of_Epiglottis	Retired_Concepts	Murine Anterior Surface of Epiglottis|Anterior Surface of Epiglottis
C23172	Mouse_Lateral_Wall_of_Oropharynx	Retired_Concepts	Murine Lateral Wall of Oropharynx|Lateral Wall of Oropharynx
C23173	Mouse_Posterior_Wall_of_Oropharynx	Retired_Concepts	Murine Posterior Wall of Oropharynx|Posterior Wall of Oropharynx
C23174	Mouse_Branchial_Cleft	Retired_Concepts	Murine Branchial Cleft|Branchial Cleft	site of neoplasm
C23175	Mouse_Superior_Wall_of_Nasopharynx	Retired_Concepts	Murine Superior Wall of Nasopharynx|Superior Wall of Nasopharynx|Superior wall of nasopharynx
C23176	Mouse_Posterior_Wall_of_Nasopharynx	Retired_Concepts	Murine Posterior Wall of Nasopharynx|Posterior Wall of Nasopharynx|Posterior wall of nasopharynx
C23177	Mouse_Lateral_Wall_of_Nasopharynx	Retired_Concepts	Murine Lateral Wall of Nasopharynx|Lateral Wall of Nasopharynx|Lateral wall of nasopharynx
C23178	Mouse_Anterior_Wall_of_Nasopharynx	Retired_Concepts	Murine Anterior Wall of Nasopharynx|Anterior Wall of Nasopharynx|Anterior wall of nasopharynx
C23179	Mouse_Hypopharynx	Retired_Concepts	Murine Hypopharynx|HYPOPHARYNX|Hypopharynx|Hypopharynx, NOS|Oro- and hypopharynx	The portion of the pharynx between the inferior portion of the oropharynx and the larynx.
C23180	Mouse_Postcricoid_Region	Retired_Concepts	Murine Postcricoid Region|Postcricoid Region
C23181	Mouse_Hypopharyngeal_Aspect_of_Aryepiglottic_Fold	Retired_Concepts	Murine Hypopharyngeal Aspect of Aryepiglottic Fold|Hypopharyngeal Aspect of Aryepiglottic Fold
C23182	Mouse_Posterior_Wall_of_Hypopharynx	Retired_Concepts	Murine Posterior Wall of Hypopharynx|Posterior Wall of Hypopharynx
C23183	Mouse_Cervical_Esophagus	Retired_Concepts	Murine Cervical Esophagus|Cervical Esophagus
C23184	Mouse_Thoracic_Esophagus	Retired_Concepts	Murine Thoracic Esophagus|Thoracic Esophagus
C23185	Mouse_Abdominal_Esophagus	Retired_Concepts	Murine Abdominal Esophagus|Abdominal Esophagus
C23186	Mouse_Upper_Third_of_Esophagus	Retired_Concepts	Murine Upper Third of Esophagus|Upper Third of Esophagus
C23187	Mouse_Middle_Third_of_Esophagus	Retired_Concepts	Murine Middle Third of Esophagus|Middle Third of Esophagus
C23188	Mouse_Lower_Third_of_Esophagus	Retired_Concepts	Murine Lower Third of Esophagus|Lower Third of Esophagus
C23189	Mouse_Cardia_NOS_Gastric_Cardia	Retired_Concepts	Murine Cardia, NOS Gastric Cardia|Cardia, NOS Gastric Cardia
C23190	Mouse_Fundus_of_Stomach	Retired_Concepts	Murine Fundus of Stomach|Fundus of Stomach	The superior portion of the body of the stomach above the level of the cardiac notch.
C23191	Mouse_Body_of_Stomach	Retired_Concepts	Murine Body of Stomach|Body of Stomach
C23192	Mouse_Gastric_Antrum	Retired_Concepts	Murine Gastric Antrum|Gastric Antrum
C23193	Mouse_Pylorus	Retired_Concepts	Murine Pylorus|Pylorus
C23194	Mouse_Lesser_Curvature_of_Stomach_NOS	Retired_Concepts	Murine Lesser Curvature of Stomach, NOS|Lesser Curvature of Stomach, NOS	not classifiable to C16.1 to C16.4
C23195	Mouse_Greater_Curvature_of_Stomach_NOS	Retired_Concepts	Murine Greater Curvature of Stomach, NOS|Greater Curvature of Stomach, NOS	not classifiable to C16.0 to C16.4
C23196	Mouse_Duodenum	Retired_Concepts	Murine Duodenum|Duodenum
C23197	Mouse_Meckel_Diverticulum	Retired_Concepts	Murine Meckel Diverticulum|Meckel Diverticulum|Meckel diverticulum	An occasional sacculation or appendage of the ileum, derived from an unobliterated yolk stalk. (Dorland, 27th ed)
C23198	Mouse_Ascending_Colon	Retired_Concepts	Murine Ascending Colon|Ascending Colon
C23199	Mouse_Hepatic_Flexure_of_Colon	Retired_Concepts	Murine Hepatic Flexure of Colon|Hepatic Flexure of Colon
C23200	Mouse_Splenic_Flexure_of_Colon	Retired_Concepts	Murine Splenic Flexure of Colon|Splenic Flexure of Colon
C23201	Mouse_Descending_Colon	Retired_Concepts	Murine Descending Colon|Descending Colon
C23202	Mouse_Head_of_Pancreas	Retired_Concepts	Murine Head of Pancreas|Head of Pancreas
C23203	Mouse_Body_of_Pancreas	Retired_Concepts	Murine Body of Pancreas|Body of Pancreas
C23204	Mouse_Tail_of_Pancreas	Retired_Concepts	Murine Tail of Pancreas|Tail of Pancreas
C23205	Mouse_Pancreatic_Duct	Retired_Concepts	Murine Pancreatic Duct|Pancreatic Duct	Ducts that collect PANCREATIC JUICE from the PANCREAS and supply it to the DUODENUM.
C23206	Mouse_Other_Specified_Parts_of_Pancreas	Retired_Concepts	Murine Other Specified Parts of Pancreas|Other Specified Parts of Pancreas
C23207	Mouse_Middle_Ear	Retired_Concepts	Murine Middle Ear|Middle Ear|Middle ear
C23208	Mouse_Maxillary_Sinus	Retired_Concepts	Murine Maxillary Sinus|Antrum, Maxillary|Maxillary Sinus|Sinus, Maxillary	One of the paired paranasal sinuses, located in the body of the maxilla, communicating with the middle meatus of the nasal cavity.
C23209	Mouse_Ethmoid_Sinus	Retired_Concepts	Murine Ethmoid Sinus|Ethmoid Sinus|Sinus, Ethmoid	Numerous small thin-walled spaces or air cells in the ethmoid bone, where they form an ethmoidal labyrinth.
C23210	Mouse_Frontal_Sinus	Retired_Concepts	Murine Frontal Sinus|Frontal Sinus|Sinus, Frontal	One of the paired, but seldom symmetrical, air spaces located between the inner and outer compact layers of the frontal bone.
C23211	Mouse_Sphenoid_Sinus	Retired_Concepts	Murine Sphenoid Sinus|Sinus, Sphenoid|Sphenoid Sinus	One of the paired paranasal sinuses, located in the body of the sphenoid bone and communicating with the highest meatus of the nasal cavity on the same side.
C23212	Mouse_Supraglottis	Retired_Concepts	Murine Supraglottis|Supraglottis	The upper part of the larynx, including the epiglottis; the area above the vocal cords.
C23213	Mouse_Subglottis	Retired_Concepts	Murine Subglottis|Subglottis
C23214	Mouse_Laryngeal_Cartilage	Retired_Concepts	Murine Laryngeal Cartilage|Laryngeal Cartilage|Laryngeal cartilage	The nine cartilages of the larynx, including the cricoid, thyroid and epiglottic, and two each of arytenoid, corniculate and cuneiform.
C23215	Mouse_Trachea_Proper	Retired_Concepts	Murine Trachea Proper|Trachea Proper
C23216	Mouse_Lung_and_Bronchus	Retired_Concepts	Murine Lung and Bronchus|BRONCHUS AND LUNG|Lung and Bronchus
C23217	Mouse_Main_Bronchus	Retired_Concepts	Murine Main Bronchus|Main Bronchus
C23218	Mouse_Upper_Lobe_Lung	Retired_Concepts	Murine Upper Lobe, Lung|Upper Lobe, Lung
C23219	Mouse_Right_Middle_Lobe_Lung	Retired_Concepts	Murine Right Middle Lobe, Lung|Right Middle Lobe, Lung
C23220	Mouse_Lower_Lobe_Lung	Retired_Concepts	Murine Lower Lobe, Lung|Lower Lobe, Lung
C23221	Mouse_Thymus_Proper	Retired_Concepts	Murine Thymus Proper|Thymus Proper
C23222	Mouse_Bones_of_Skull_and_Face_and_Associated_Joints	Retired_Concepts	Murine Bones of Skull and Face and Associated Joints|Bones of Skull and Face and Associated Joints	excludes mandible C41.1
C23223	Mouse_Mandible	Retired_Concepts	Murine Mandible|Mandible	The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.
C23224	Mouse_Skin_of_Lip_NOS	Retired_Concepts	Murine Skin of Lip, NOS|Skin of Lip, NOS
C23225	Mouse_External_Ear	Retired_Concepts	Murine External Ear|Auricle|Ear, External|External Ear|External ear|Pinna
C23226	Mouse_Skin_of_Other_and_Unspecified_Parts_of_Face	Retired_Concepts	Murine Skin of Other and Unspecified Parts of Face|Skin of Other and Unspecified Parts of Face
C23227	Mouse_Skin_of_Scalp_and_Neck	Retired_Concepts	Murine Skin of Scalp and Neck|Skin of Scalp and Neck
C23228	Mouse_Skin_of_Trunk	Retired_Concepts	Murine Skin of Trunk|Skin of Trunk
C23229	Mouse_Skin_of_Upper_Limb_and_Shoulder	Retired_Concepts	Murine Skin of Upper Limb and Shoulder|Skin of Upper Limb and Shoulder
C23230	Mouse_Skin_of_Lower_Limb_and_Hip	Retired_Concepts	Murine Skin of Lower Limb and Hip|Skin of Lower Limb and Hip
C23231	Mouse_Retroperitoneum	Retired_Concepts	Murine Retroperitoneum|Retroperitoneum	An area occupying the most posterior aspect of the abdominal cavity. It is bounded laterally by the borders of the quadratus lumborum muscles and extends from the diaphragm to the brim of the true pelvis, where it continues as the pelvic extraperitoneal space.
C23232	Mouse_Nipple	Retired_Concepts	Murine Nipple|Nipple	The conic organs which usually give outlet to milk from the mammary glands.
C23233	Mouse_Central_Portion_of_Breast	Retired_Concepts	Murine Central Portion of Breast|Central Portion of Breast
C23234	Mouse_Upper-inner_Quadrant_of_Breast	Retired_Concepts	Murine Upper-inner Quadrant of Breast|Upper-inner Quadrant of Breast
C23235	Mouse_Lower-inner_Quadrant_of_Breast	Retired_Concepts	Murine Lower-inner Quadrant of Breast|Lower-inner Quadrant of Breast
C23236	Mouse_Upper-outer_Quadrant_of_Breast	Retired_Concepts	Murine Upper-outer Quadrant of Breast|Upper-outer Quadrant of Breast
C23237	Mouse_Lower-outer_Quadrant_of_Breast	Retired_Concepts	Murine Lower-outer Quadrant of Breast|Lower-outer Quadrant of Breast
C23238	Mouse_Axillary_Tail_of_Breast	Retired_Concepts	Murine Axillary Tail of Breast|Axillary Tail of Breast
C23239	Mouse_Female_Genital_Organs	Retired_Concepts	Murine Female Genital Organs|Female Genital Organs|Female genital organs|Female genital organs (all sites)|Female genital tract, NOS
C23240	Mouse_Labium_Majus	Retired_Concepts	Murine Labium Majus|Labium Majus
C23241	Mouse_Labium_Minus	Retired_Concepts	Murine Labium Minus|Labium Minus
C23242	Mouse_Clitoris	Retired_Concepts	Murine Clitoris|Clitoris
C23243	Mouse_Endocervix	Retired_Concepts	Murine Endocervix|Endocervix
C23244	Mouse_Exocervix	Retired_Concepts	Murine Exocervix|Exocervix
C23245	Mouse_Cervix_Uteri	Retired_Concepts	Murine Cervix Uteri|Cervix|Cervix Uteri|Genital System, Female, Cervix|Uterus, cervix
C23246	Mouse_Isthmus_Uteri	Retired_Concepts	Murine Isthmus Uteri|Isthmus Uteri
C23247	Mouse_Endometrium	Retired_Concepts	Murine Endometrium|Corpus Uteri / Endometrium|Endometrium|endometrium	The Corpus uteri, or body of uterus, is the part of the uterus above the isthmus, comprising about two thirds of the non-pregnant organ. The endometrium, or tunica mucosa, is the mucous membrane comprising the inner layer of the uterine wall; it consists of a simple columnar epithelium and a lamina propria that contains simple tubular uterine glands. The structure, thickness, and state of the endometrium undergo marked change with the menstrual cycle.
C23248	Mouse_Myometrium	Retired_Concepts	Murine Myometrium|Myometrium	The smooth muscle coat of the uterus, which forms the main mass of the organ.
C23249	Mouse_Fundus_Uteri	Retired_Concepts	Murine Fundus Uteri|Fundus Uteri
C23250	Mouse_Corpus_Uteri	Retired_Concepts	Murine Corpus Uteri|CORPUS UTERI|Corpus Uteri|Uterus, corpus	The hollow muscular organ in which the impregnated ovum is developed into the child; it is about 7.5 cm in length in the nonpregnant woman, and consists of a main portion (body) with an elongated lower part (neck), at the extremity of which is the opening (os). The upper rounded portion of the uterus, opposite the os, is the fundus, at each extremity of which is the horn marking the part where the uterine tube joins the uterus and through which the ovum reaches the uterine cavity after leaving the ovary. The organ is supported in the pelvic cavity by the broad ligaments, round ligaments, cardinal ligaments, and rectouterine and vesicouterine folds or ligaments. SYN metra, womb.
C23251	Mouse_Other_and_Unspecified_Female_Genital_Organs	Retired_Concepts	Murine Other and Unspecified Female Genital Organs|OTHER AND UNSPECIFIED FEMALE GENITAL ORGANS|Other and Unspecified Female Genital Organs
C23252	Mouse_Broad_Ligament	Retired_Concepts	Murine Broad Ligament|Broad Ligament	A broad fold of peritoneum that extends from the side of the uterus to the wall of the pelvis.
C23253	Mouse_Round_Ligament	Retired_Concepts	Murine Round Ligament|Round Ligament	A fibromuscular band that attaches to the uterus and then passes along the broad ligament, out through the inguinal ring, and into the labium majus.
C23254	Mouse_Parametrium	Retired_Concepts	Murine Parametrium|Parametrium
C23255	Mouse_Uterine_Adnexa	Retired_Concepts	Murine Uterine Adnexa|Uterine Adnexa	The appendages of the UTERUS: the FALLOPIAN TUBES, OVARIES, and supporting ligaments of the uterus.
C23256	Mouse_Other_Specified_Parts_of_Female_Genital_Organs	Retired_Concepts	Murine Other Specified Parts of Female Genital Organs|Other Specified Parts of Female Genital Organs	The excretory organ of the embryo, collective Wolffian tubules, which forms the urogenital fold from which the reproductive organs develop. The mesonephros is the permanent kidney in fish and amphibians, but atrophies in reptiles, birds, and mammals.
C23257	Mouse_Male_Genital_Organs	Retired_Concepts	Murine Male Genital Organs|Male Genital Organs|Male genital organs|Male genital organs (all sites)|Male genital organs, NOS|OTHER AND UNSPECIFIED MALE GENITAL ORGANS|Other specified parts of male genital organs
C23258	Mouse_Prepuce	Retired_Concepts	Murine Prepuce|Prepuce
C23259	Mouse_Glans_Penis	Retired_Concepts	Murine Glans Penis|Glans Penis
C23260	Mouse_Body_of_Penis	Retired_Concepts	Murine Body of Penis|Body of Penis
C23261	Mouse_Undescended_Testis	Retired_Concepts	Murine Undescended Testis|Undescended Testis	A developmental defect characterized by failure of the testes to descend into the scrotum. (Dorland, 27th ed)
C23262	Mouse_Descended_Testis	Retired_Concepts	Murine Descended Testis|Descended Testis
C23263	Mouse_Epididymis	Retired_Concepts	Murine Epididymis|Epididymis
C23264	Mouse_Spermatic_Cord	Retired_Concepts	Murine Spermatic Cord|Spermatic Cord
C23265	Mouse_Other_Specified_Parts_of_Male_Genital_Organs	Retired_Concepts	Murine Other Specified Parts of Male Genital Organs|Other Specified Parts of Male Genital Organs
C23266	Mouse_Trigone_of_Bladder	Retired_Concepts	Murine Trigone of Bladder|Trigone of Bladder
C23267	Mouse_Dome_of_Bladder	Retired_Concepts	Murine Dome of Bladder|Dome of Bladder
C23268	Mouse_Lateral_Wall_of_Bladder	Retired_Concepts	Murine Lateral Wall of Bladder|Lateral Wall of Bladder
C23269	Mouse_Anterior_Wall_of_Bladder	Retired_Concepts	Murine Anterior Wall of Bladder|Anterior Wall of Bladder
C23270	Mouse_Posterior_Wall_of_Bladder	Retired_Concepts	Murine Posterior Wall of Bladder|Posterior Wall of Bladder
C23271	Mouse_Bladder_Neck	Retired_Concepts	Murine Bladder Neck|Bladder Neck
C23272	Mouse_Ureteric_Orifice	Retired_Concepts	Murine Ureteric Orifice|Ureteric Orifice
C23273	Mouse_Urachus	Retired_Concepts	Murine Urachus|Urachus	The urinary canal of the fetus; postnatally it is usually a fibrous cord but occasionally persists as a vesicoumbilical fistula.
C23274	Mouse_Paraurethral_Gland	Retired_Concepts	Murine Paraurethral Gland|Paraurethral Gland
C23275	Mouse_Eye_and_Adnexa	Retired_Concepts	Murine Eye and Adnexa|EYE AND ADNEXA|Eye and Adnexa
C23276	Mouse_Conjunctiva	Retired_Concepts	Murine Conjunctiva|Conjunctiva	A thin, transparent mucous membrane that covers the posterior surface of lids (palpebral conjunctiva) and the outer surface of the sclera (bulbar conjunctiva).
C23277	Mouse_Cornea	Retired_Concepts	Murine Cornea|Cornea|Cornea, NOS	The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous epithelium, Bowman's membrane, stroma, DESCEMET'S MEMBRANE, and mesenchymal endothelium. It serves as the first refracting medium of the eye. It is structurally continuous with the sclera, is avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the trigeminal nerve via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)
C23278	Mouse_Retina	Retired_Concepts	Murine Retina|Retina	The ten-layered nervous tissue membrane of the eye. It is continuous with the OPTIC NERVE and receives images of external objects and transmits visual impulses to the brain. Its outer surface is in contact with the CHOROID and the inner surface with the VITREOUS BODY. The outer-most layer is pigmented, whereas the inner nine layers are transparent.
C23279	Mouse_Choroid	Retired_Concepts	Murine Choroid|Choroid	The thin, highly vascular membrane covering most of the posterior of the eye between the RETINA and SCLERA.
C23280	Mouse_Ciliary_Body	Retired_Concepts	Murine Ciliary Body|Ciliary Body|ciliary body	A ring of tissue extending from the scleral spur to the ora serrata of the retina. It consists of the uveal portion and the epithelial portion. The ciliary muscle is in the uveal portion and the ciliary processes are in the epithelial portion.
C23281	Mouse_Lacrimal_Gland	Retired_Concepts	Murine Lacrimal Gland|Lacrimal Gland|Lacrimal gland
C23282	Mouse_Orbit	Retired_Concepts	Murine Orbit|Eye Socket|Ocular Orbit|Orbit|Orbit, NOS|Orbital Cavity	The bony cavity of the skull which contains the eye, anterior portion of the optic nerve, ocular muscles and ocular adnexa.  Seven bones contribute to the structure of the orbit: the frontal, maxillary, zygomatic, sphenoid, lacrimal, ethmoid, and palatine bones.
C23283	Mouse_Meninges	Retired_Concepts	Murine Meninges|MENINGES|Meninges|Meninges, NOS
C23284	Mouse_Cerebral_Meninges	Retired_Concepts	Murine Cerebral Meninges|Cerebral Meninges|Cerebral meninges
C23285	Mouse_Spinal_Meninges	Retired_Concepts	Murine Spinal Meninges|Spinal Meninges|Spinal meninges
C23286	Mouse_Cerebral_Hemispheres	Retired_Concepts	Murine Cerebral Hemispheres|Cerebral Hemispheres|Cerebrum
C23287	Mouse_Frontal_Lobe	Retired_Concepts	Murine Frontal Lobe|Frontal Lobe|Frontal lobe|frontal cortex	The anterior part of the cerebral hemisphere.
C23288	Mouse_Temporal_Lobe	Retired_Concepts	Murine Temporal Lobe|Temporal Lobe|Temporal lobe|temporal cortex	Lower lateral part of the cerebral hemisphere.
C23289	Mouse_Parietal_Lobe	Retired_Concepts	Murine Parietal Lobe|Parietal Lobe|Parietal lobe	Upper central part of the cerebral hemisphere.
C23290	Mouse_Occipital_Lobe	Retired_Concepts	Murine Occipital Lobe|Occipital Lobe|Occipital lobe|occipital cortex	Posterior part of the cerebral hemisphere.
C23291	Mouse_Ventricles_Brain	Retired_Concepts	Murine Ventricles, Brain|Ventricle|Ventricle, NOS|Ventricles|Ventricles, Brain	Four connected cavities (hollow spaces) in the brain.
C23292	Mouse_Craniopharyngeal_Duct	Retired_Concepts	Murine Craniopharyngeal Duct|Craniopharyngeal Duct|Craniopharyngeal duct
C23293	Mouse_Lymph_Nodes_of_Head_Face_and_Neck	Retired_Concepts	Murine Lymph Nodes of Head, Face and Neck|Lymph Nodes of Head, Face and Neck
C23294	Mouse_Intrathoracic_Lymph_Nodes	Retired_Concepts	Murine Intrathoracic Lymph Nodes|Intrathoracic Lymph Nodes
C23295	Mouse_Intra-abdominal_Lymph_Nodes	Retired_Concepts	Murine Intra-abdominal Lymph Nodes|Intra-abdominal Lymph Nodes
C23296	Mouse_Lymph_Nodes_of_Axilla_or_Arm	Retired_Concepts	Murine Lymph Nodes of Axilla or Arm|Lymph Nodes of Axilla or Arm
C23297	Mouse_Lymph_Nodes_of_Inguinal_Region_or_Leg	Retired_Concepts	Murine Lymph Nodes of Inguinal Region or Leg|Lymph Nodes of Inguinal Region or Leg
C23298	Mouse_Pelvic_Lymph_Nodes	Retired_Concepts	Murine Pelvic Lymph Nodes|Pelvic Lymph Nodes
C23299	Mouse_Lymph_Nodes_of_Multiple_Regions	Retired_Concepts	Murine Lymph Nodes of Multiple Regions|Lymph Nodes of Multiple Regions
C23300	Mouse_Amnion	Retired_Concepts	Murine Amnion|Amnion|amnion	The extraembryonic membrane which contains the EMBRYO and AMNIOTIC FLUID.
C23301	Mouse_Bones	Retired_Concepts	Murine Bones|Bone, NOS|Bones|bone	is an organ that primarily consists of bone tissue organized into compact (cortical) and cancellous bone (macroscopic organ components); together with other bones, cartilages and joints, it constitutes the skeletal system. Example(s): femur, sternum, maxilla, vertebra, talus.
C23302	Mouse_Mammary_Gland	Retired_Concepts	Murine Mammary Gland|Mammary|Mammary Gland|mammary gland
C23303	Mouse_Areola	Retired_Concepts	Murine Areola|Areola|areola
C23304	Mouse_Mammary_Gland_Fat-pad	Retired_Concepts	Murine Mammary Gland Fat-pad|Mammary Gland Fat-pad|mammary gland fat-pad
C23305	Mouse_Mammary_Gland_Parenchyma	Retired_Concepts	Murine Mammary Gland Parenchyma|Mammary Gland Parenchyma|mammary gland parenchyma
C23306	Mouse_Myocardium	Retired_Concepts	Murine Myocardium|Cardiac Muscle|Heart Muscle|Myocardium|myocardium	The muscle tissue of the HEART composed of striated, involuntary muscle known as cardiac muscle.
C23307	Mouse_Artery	Retired_Concepts	Murine Artery|Artery|artery	The vessels carrying blood away from the heart.
C23308	Mouse_Cartilage	Retired_Concepts	Murine Cartilage|Cartilage	A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix of type II COLLAGEN and CHONDROITIN SULFATE. It is divided into three types: hyaline cartilage, fibrocartilage, and yellow or elastic white fibrocartilage.
C23309	Mouse_Connective_Tissue	Retired_Concepts	Murine Connective Tissue|Connective Tissue	Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.
C23310	Mouse_Anus	Retired_Concepts	Murine Anus|Anus|Anus, NOS|anus
C23311	Mouse_Bile_Duct	Retired_Concepts	Murine Bile Duct|Bile Duct|bile duct	Any of the ducts conveying bile between the liver and the intestine, including hepatic, cystic, and common bile duct.
C23312	Mouse_Gall_Bladder	Retired_Concepts	Murine Gall Bladder|Gall Bladder|Gallbladder|Gallbladder/Biliary system|Gastrointestinal Tract, Gall Bladder
C23313	Mouse_Gastrointestinal_System	Retired_Concepts	Murine Gastrointestinal System|Gastrointestinal System|Gastrointestinal tract, NOS|gastrointestinal tract
C23314	Mouse_Large_Intestine	Retired_Concepts	Murine Large Intestine|Large Intestine
C23315	Mouse_Appendix	Retired_Concepts	Murine Appendix|Appendix
C23316	Mouse_Cecum	Retired_Concepts	Murine Cecum|Cecum
C23317	Mouse_Colon	Retired_Concepts	Murine Colon|Colon|Colon, NOS|Large Intestine|colon
C23318	Mouse_Right_Colon	Retired_Concepts	Murine Right Colon|Right Colon
C23319	Mouse_Sigmoid_Colon	Retired_Concepts	Murine Sigmoid Colon|Sigmoid Colon|sigmoid colon
C23320	Mouse_Transverse_Colon	Retired_Concepts	Murine Transverse Colon|Transverse Colon|transverse colon
C23321	Mouse_Small_Intestine	Retired_Concepts	Murine Small Intestine|Gastrointestinal Track, Small Intestine|Small Intestine|Small intestine|Small intestine, NOS
C23322	Mouse_Ileum	Retired_Concepts	Murine Ileum|Ileum|ileum	excludes ileocecal valve C18.0
C23323	Mouse_Jejunum	Retired_Concepts	Murine Jejunum|Jejunum|jejunum
C23324	Mouse_Esophagus	Retired_Concepts	Murine Esophagus|Esophagus|Esophagus, NOS|Gastrointestinal Track, Esophagus|esophagus	The portion of the digestive canal between the pharynx and stomach. It is about 25 cm long and consists of three parts: the cervical part, from the cricoid cartilage to the thoracic inlet; thoracic part, from thoracic inlet to the diaphragm; and abdominal part, below the diaphragm to the cardiac opening of the stomach.
C23325	Mouse_Rectum	Retired_Concepts	Murine Rectum|Rectum|Rectum, NOS|rectum
C23326	Mouse_Stomach	Retired_Concepts	Murine Stomach|Gastrointestinal Tract, Stomach|Stomach|Stomach, NOS|stomach	An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
C23327	Mouse_Liver	Retired_Concepts	Murine Liver|Liver|liver
C23328	Mouse_Pancreas	Retired_Concepts	Murine Pancreas|Gastrointestinal Track, Pancreas|Pancreas|Pancreas, NOS|pancreas	A mixed exocrine and endocrine gland situated transversely across the posterior abdominal wall in the epigastric and hypochondriac regions. The endocrine portion is comprised of the ISLETS OF LANGERHANS, while the exocrine portion is a compound acinar gland that secretes digestive enzymes.
C23329	Mouse_Ear	Retired_Concepts	Murine Ear|Ear|ear	The organ of hearing: composed of the external ear, which includes the auricle and the external acoustic, or auditory, meatus; the middle ear, or the tympanic cavity with its ossicles; and the internal ear or inner ear, or labyrinth, which includes the semicircular canals, vestibule, and cochlea. SEE ALSO auricle. SYN auris.
C23330	Mouse_Cochlea	Retired_Concepts	Murine Cochlea|Cochlea|Cochlear Organ|cochlea	The part of the internal ear that is concerned with hearing. It forms the anterior part of the labyrinth, is conical, and is placed almost horizontally anterior to the vestibule.
C23331	Mouse_Adrenal_Cortex	Retired_Concepts	Murine Adrenal Cortex|Adrenal Cortex|Cortex of Adrenal Gland	The outer layer of the adrenal gland. It secretes mineralocorticoids, androgens, and glucocorticoids.
C23332	Mouse_Adrenal_Medulla	Retired_Concepts	Murine Adrenal Medulla|Adrenal Medulla|Medulla of adrenal gland|adrenal medulla	The inner part of the adrenal gland; it synthesizes, stores and releases catecholamines.
C23333	Mouse_Pineal_Gland	Retired_Concepts	Murine Pineal Gland|Pineal Body|Pineal Gland|pineal gland	A small conical midline body attached to the posterior part of the third ventricle and lying between the superior colliculi, below the splenium of the corpus callosum.
C23334	Mouse_Pituitary_Gland	Retired_Concepts	Murine Pituitary Gland|NERVOUS SYSTEM, PITUITARY|Pituitary|Pituitary Gland|Pituitary gland	A small, unpaired gland situated in the sella turcica tissue. It is connected to the hypothalamus by a short stalk.
C23335	Mouse_Thyroid	Retired_Concepts	Murine Thyroid|HEAD AND NECK, THYROID|Thyroid|Thyroid gland|thyroid	A highly vascular endocrine gland consisting of two lobes, one on either side of the trachea, joined by a narrow isthmus; it produces the thyroid hormones which are concerned in regulating the metabolic rate of the body.
C23336	Mouse_Eye	Retired_Concepts	Murine Eye|Eye|Eye, NOS|Eyeball
C23337	Mouse_Female_Reproductive_System	Retired_Concepts	Murine Female Reproductive System|Female Reproductive System|GENITAL SYSTEM, FEMALE|female genital
C23338	Mouse_Fallopian_Tube	Retired_Concepts	Murine Fallopian Tube|Fallopian Tube|Fallopian tube	Two long muscular tubes that transport ova from the ovaries to the uterus. They extend from the horn of the uterus to the ovaries and consist of an ampulla, an infundibulum, an isthmus, two ostia, and a pars uterina. The walls of the tubes are composed of three layers: mucosal, muscular, and serosal.
C23339	Mouse_Ovary	Retired_Concepts	Murine Ovary|GENITAL SYSTEM, FEMALE, OVARY|Ovaries|Ovary|ovary
C23340	Mouse_Uterus	Retired_Concepts	Murine Uterus|GENITAL SYSTEM, FEMALE, UTERUS|Uterus|Uterus, NOS|uterus	The hollow muscular organ in which the impregnated ovum is developed into the child; it is about 7.5 cm in length in the nonpregnant woman, and consists of a main portion (body) with an elongated lower part (neck), at the extremity of which is the opening (os). The upper rounded portion of the uterus, opposite the os, is the fundus, at each extremity of which is the horn marking the part where the uterine tube joins the uterus and through which the ovum reaches the uterine cavity after leaving the ovary. The organ is supported in the pelvic cavity by the broad ligaments, round ligaments, cardinal ligaments, and rectouterine and vesicouterine folds or ligaments. SYN metra, womb.
C23341	Mouse_Pregnant_Uterus	Retired_Concepts	Murine Pregnant Uterus|Pregnant Uterus
C23342	Mouse_Vagina	Retired_Concepts	Murine Vagina|GENITAL SYSTEM, FEMALE, VAGINA|Vagina|vagina
C23343	Mouse_Vulva	Retired_Concepts	Murine Vulva|Vulva|Vulva, NOS
C23344	Mouse_Penis	Retired_Concepts	Murine Penis|GENITAL SYSTEM, MALE, PENIS|Penis|Penis, NOS|penis
C23345	Mouse_Prostate_MF	Retired_Concepts	Murine Prostate MF|Prostate MF|prostate MF
C23346	Mouse_Testes	Retired_Concepts	Murine Testes|Genital System, Male, Testis|Testes|Testicles|Testis|Testis, NOS
C23347	Mouse_Urinary_System	Retired_Concepts	Murine Urinary System|Urinary System|Urinary Tract|Urinary system, NOS|Urinary tract (all sites)|urinary
C23348	Mouse_Bladder	Retired_Concepts	Murine Bladder|Bladder|Bladder, NOS|Urinary System, Bladder|bladder
C23349	Mouse_Kidney	Retired_Concepts	Murine Kidney|Kidney|Kidney, NOS|Kidneys|URINARY SYSTEM, KIDNEY|kidney
C23350	Mouse_Ureter	Retired_Concepts	Murine Ureter|Ureter|ureter	One of a pair of thick-walled tubes that transports urine from the KIDNEY PELVIS to the BLADDER.
C23351	Mouse_Urethra	Retired_Concepts	Murine Urethra|Urethra|urethra
C23352	Mouse_Head_and_Neck	Retired_Concepts	Murine Head and Neck|H and N - Head And Neck|Head and Neck	For oncology, area of the body generally construed to comprise base of skull and facial bones, sinuses, orbits, salivary glands, oral cavity, oropharynx, larynx, thyroid, facial and neck musculature and lymph nodes draining these areas. (DCTD-CO)
C23353	Mouse_Head	Retired_Concepts	Murine Head|Head
C23354	Mouse_Larynx	Retired_Concepts	Murine Larynx|Head and Neck, Larynx|Larynx|Larynx, NOS|larynx
C23355	Mouse_Mouth	Retired_Concepts	Murine Mouth|Mouth|Mouth, NOS
C23356	Mouse_Tongue	Retired_Concepts	Murine Tongue|Tongue|Tongue, NOS|tongue
C23357	Mouse_Nasopharynx	Retired_Concepts	Murine Nasopharynx|Nasopharynx|Nasopharynx, NOS|nasopharynx
C23358	Mouse_Nasal_Cavity	Retired_Concepts	Murine Nasal Cavity|Nasal Cavity|nasal cavity	The proximal portion of the respiratory passages on either side of the nasal septum, lined with ciliated mucosa, extending from the nares to the pharynx.
C23359	Mouse_Pharynx	Retired_Concepts	Murine Pharynx|HEAD AND NECK, PHARYNX|Pharynx|Pharynx, NOS|pharynx
C23360	Mouse_Salivary_Glands	Retired_Concepts	Murine Salivary Glands|HEAD AND NECK, SALIVARY GLANDS|OTHER AND UNSPECIFIED MAJOR SALIVARY GLANDS|Salivary Glands|Salivary gland
C23361	Mouse_Parotid	Retired_Concepts	Murine Parotid|Parotid|parotid
C23362	Mouse_Trachea	Retired_Concepts	Murine Trachea|Trachea|trachea	The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.
C23363	Mouse_Limb	Retired_Concepts	Murine Limb|Extremity|Limb|limb
C23364	Mouse_Lymphoreticular_Tissue	Retired_Concepts	Murine Lymphoreticular Tissue|Lymphoreticular Tissue|lymphoreticular
C23365	Mouse_Bone_Marrow	Retired_Concepts	Murine Bone Marrow|Bone Marrow|bone marrow	The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
C23366	Mouse_Spleen	Retired_Concepts	Murine Spleen|Reticuloendothelial System, Spleen|Spleen|spleen
C23367	Mouse_Thymus_Gland	Retired_Concepts	Murine Thymus Gland|Reticuloendothelial System, Thymus|Thymus|Thymus Gland
C23368	Mouse_Blood	Retired_Concepts	Murine Blood|Blood|Peripheral Blood|Reticuloendothelial System, Blood|whole blood
C23369	Mouse_Muscle_Tissue	Retired_Concepts	Murine Muscle Tissue|Muscle|Muscle Tissue
C23370	Mouse_Striated_Muscle	Retired_Concepts	Murine Striated Muscle|Striated Muscle|skeletal muscle
C23371	Mouse_Smooth_Muscle	Retired_Concepts	Murine Smooth Muscle|Smooth Muscle|smooth muscle	Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)
C23372	Mouse_Central_Nervous_System	Retired_Concepts	Murine Central Nervous System|CNS|CNS - CENTRAL NERVOUS SYSTEM|Central Nervous System|Central nervous system (all sites) (Mitelman)|NERVOUS SYSTEM, CNS|central nervous system	That portion of the nervous system consisting of the brain and spinal cord. (Dorland, 28th ed) (MSH98)
C23373	Mouse_Brain	Retired_Concepts	Murine Brain|Brain|Brain, NOS|Brain, Nervous System|Nervous System, Brain|brain	That part of the central nervous system contained within the cranium, comprising the prosencephalon, mesencephalon, and rhombencephalon. It is derived from the anterior part of the embryonic neural tube. Functions include muscle control and coordination, sensory reception and integration, speech production, memory storage, and the elaboration of thought and emotions. (Dorland, 28th ed) (MSH98)
C23374	Mouse_Amygdala	Retired_Concepts	Murine Amygdala|Amygdala|amygdala	Almond-shaped group of basal nuclei anterior to the inferior horn of the lateral ventricle of the brain, within the temporal lobe. The amygdala is part of the limbic system.
C23375	Mouse_Brain_Stem	Retired_Concepts	Murine Brain Stem|Brain Stem|Brain stem	The part of the brain that connects the cerebral hemispheres with the spinal cord. It consists of the MESENCEPHALON, PONS, and MEDULLA OBLONGATA.
C23376	Mouse_Medulla_Oblongata	Retired_Concepts	Murine Medulla Oblongata|Medulla Oblongata|Myelencephalon|medulla oblongata	The lower portion of the brainstem located between the pons and brainstem.  This structure contains several descending and ascending tracts, lower cranial nerve nuclei, a significant proportion of the reticular system of the brainstem and other structures.
C23377	Mouse_Cortex	Retired_Concepts	Murine Cortex|Cortex	The outer layer of the adrenal gland. It secretes mineralocorticoids, androgens, and glucocorticoids.
C23378	Mouse_Hippocampus	Retired_Concepts	Murine Hippocampus|Hippocampus|hippocampus	A curved elevation of gray matter extending the entire length of the floor of the temporal horn of the lateral ventricle (Dorland, 28th ed). The hippocampus, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
C23379	Mouse_Cerebellum	Retired_Concepts	Murine Cerebellum|Cerebellum|Cerebellum, NOS|cerebellum	Part of the metencephalon that lies in the posterior cranial fossa behind the brain stem. It is concerned with the coordination of movement.
C23380	Mouse_Corpus_Callosum	Retired_Concepts	Murine Corpus Callosum|Corpus Callosum|corpus callosum	Broad plate of dense myelinated fibers that reciprocally interconnect regions of the cortex in all lobes with corresponding regions of the opposite hemisphere. The corpus callosum is located deep in the longitudinal fissure.
C23381	Mouse_Basal_Ganglia	Retired_Concepts	Murine Basal Ganglia|Basal Ganglia|basal ganglia	Large subcortical nuclear masses derived from the telencephalon and located in the basal regions of the cerebral hemispheres.
C23382	Mouse_Corpus_Striatum	Retired_Concepts	Murine Corpus Striatum|Corpus Striatum|corpus striatum	Striped gray and white matter consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the thalamus in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The white matter is the internal capsule.
C23383	Mouse_Globus_Pallidus	Retired_Concepts	Murine Globus Pallidus|Globus Pallidus|globus pallidus	The representation of the phylogenetically oldest part of the corpus striatum called the paleostriatum. It forms the smaller, more medial part of the lentiform nucleus.
C23384	Mouse_Striatum	Retired_Concepts	Murine Striatum|Striatum|striatum
C23385	Mouse_Caudate_Nucleus	Retired_Concepts	Murine Caudate Nucleus|Caudate Nucleus|caudate nucleus	Elongated gray mass of the neostriatum located adjacent to the lateral ventricle of the brain.
C23386	Mouse_Putamen	Retired_Concepts	Murine Putamen|Putamen|putamen	The largest and most lateral of the basal ganglia lying between the lateral medullary lamina of the globus pallidus and the external capsule. It is part of the neostriatum and forms part of the lentiform nucleus along with the globus pallidus.
C23387	Mouse_Substantia_Nigra	Retired_Concepts	Murine Substantia Nigra|Substantia Nigra|substantia nigra
C23388	Mouse_Subthalamic_Nucleus	Retired_Concepts	Murine Subthalamic Nucleus|Subthalamic Nucleus|subthalamic nucleus	Lens-shaped structure on the inner aspect of the internal capsule. The subthalamic nucleus and pathways traversing this region are concerned with the integration of somatic motor function. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p52)
C23389	Mouse_Prosencephalon	Retired_Concepts	Murine Prosencephalon|Prosencephalon|prosencephalon	The part of the brain developed from the most rostral of the three primary vesicles of the embryonic neural tube and consisting of the DIENCEPHALON and TELENCEPHALON.
C23390	Mouse_Diencephalon	Retired_Concepts	Murine Diencephalon|Diencephalon|diencephalon	The paired caudal parts of the prosencephalon from which the THALAMUS, HYPOTHALAMUS, EPITHALAMUS, and SUBTHALAMUS are derived.
C23391	Mouse_Epithalamus	Retired_Concepts	Murine Epithalamus|Epithalamus|epithalamus	The dorsal posterior subdivision of the diencephalon. The epithalamus is generally considered to include the habenular nuclei (HABENULA) and associated fiber bundles, the PINEAL BODY, and the epithelial roof of the third ventricle. The anterior and posterior paraventricular nuclei of the thalamus are included with the THALAMIC NUCLEI although they develop from the same pronuclear mass as the epithalamic nuclei and are sometimes considered part of the epithalamus.
C23392	Mouse_Hypothalamus	Retired_Concepts	Murine Hypothalamus|Hypothalamus|hypothalamus	Hypothalamus is an important supervisory center in the brain, rich in ganglia, nerve fibers, and synaptic connections. It is composed of several sections called nuclei, each of which controls a specific function. The hypothalamus regulates body temperature, blood pressure, heartbeat, metabolism of fats and carbohydrates, and sugar levels in the blood. Through direct attachment to the pituitary gland, the hypothalamus also meters secretions controlling water balance and milk production in the female. The role of the hypothalamus in awareness of pleasure and pain is well established in the laboratory. It is involved in the expression of emotions, such as fear and rage, and in sexual behaviors. Despite its numerous vital functions, the hypothalamus in humans accounts for only 1/300 of total brain weight, and is about the size of an almond. Structurally, it is joined to the thalamus; the two work together to monitor the sleep-wake cycle.
C23393	Mouse_Thalamus	Retired_Concepts	Murine Thalamus|Thalamus|thalamus	Paired bodies containing mostly gray substance and forming part of the lateral wall of the third ventricle of the brain. The thalamus represents the major portion of the diencephalon and is commonly divided into cellular aggregates known as nuclear groups.
C23394	Mouse_Tectum_Mesencephali	Retired_Concepts	Murine Tectum Mesencephali|Tectum Mesencephali|tectum mesencephali
C23395	Mouse_Corpora_Quadrigemina	Retired_Concepts	Murine Corpora Quadrigemina|Corpora Quadrigemina|corpora quadrigemina
C23396	Mouse_Dorsal_Root_Ganglion	Retired_Concepts	Murine Dorsal Root Ganglion|Dorsal Root Ganglion|dorsal root ganglion	Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.
C23397	Mouse_Notochord	Retired_Concepts	Murine Notochord|Notochord|notochord	The rod-shaped body, composed of cells derived from the mesoblast and defining the primitive axis of the embryo. In lower vertebrates, it persists throughout life as the main axial support of the body, but in higher vertebrates it is replaced by the vertebral column.
C23398	Mouse_Spinal_Cord	Retired_Concepts	Murine Spinal Cord|Spinal Cord|Spinal cord	is an organ that consists of neural tissue (which is organized into gray matter and white matter) and the central canal (organ cavity); it is embryologically derived from the caudal part of the neural tube. Together with the brain, the spinal cord constitutes the central nervous system. Example(s): There is only one spinal cord; it is an instance of organ.
C23399	Mouse_Peripheral_Nervous_System	Retired_Concepts	Murine Peripheral Nervous System|Peripheral Nervous System|peripheral nervous system	The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.
C23400	Mouse_Nerve	Retired_Concepts	Murine Nerve|Nerve|Nervous	is an organ that primarily consists of nerve fibers aggregated into fasciculi by connective tissue to form an elongated, cable-like organ; together with other nerves it constitutes the peripheral nervous system. Example(s): radial nerve, sciatic nerve, vagus, chorda tympani, phrenic nerve, pelvic splanchnic nerve [but not some nerve plexuses that include in their name the term "nerve" (e.g., carotid nerve, superior hypogastric nerve)].
C23401	Mouse_Sympathetic_Ganglion	Retired_Concepts	Murine Sympathetic Ganglion|Sympathetic Ganglion|sympathetic ganglion	Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.
C23402	Mouse_Lung	Retired_Concepts	Murine Lung|Lung|Lung, NOS|Lungs|Respiratory System, Lung	Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
C23403	Mouse_Pleura	Retired_Concepts	Murine Pleura|Pleura|pleura	The thin serous membrane enveloping the lungs and lining the thoracic cavity.
C23404	Mouse_Skin	Retired_Concepts	Murine Skin|Skin|Skin, NOS	The natural covering of the body; the skin.
C23405	Mouse_Soft_Tissue	Retired_Concepts	Murine Soft Tissue|Soft Tissue|Soft tissue
C23406	Mouse_Adipose_Tissue	Retired_Concepts	Murine Adipose Tissue|Adipose|Adipose Tissue	Connective tissue composed of fat cells lodged in the meshes of areolar tissue.
C23407	Mouse_Synovium	Retired_Concepts	Murine Synovium|Synovium|synovium	The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.
C23408	Mouse_B-Lymphocytes	Retired_Concepts	Murine B-Lymphocytes|B-Cells|B-Lymphocytes|B-cell|Bursa-Dependent Lymphocytes|bursa-equivalent lymphocyte	Immunologically important lymphocyte that is not thymus-dependent, is either short-lived and naive or long-lived and of memory phenotype, and resembles the bursa-derived lymphocyte of birds in that it is responsible for the production of immunoglobulins.
C23409	Mouse_Basal_Cells	Retired_Concepts	Murine Basal Cells|Basal Cells|basal	cell in lowest layer of a stratified tissue, e.g., epithelium; site of tissue renewal.
C23410	Mouse_T-Lymphocytes	Retired_Concepts	Murine T-Lymphocytes|T Cells|T-Cells|T-Lymphocytes|Thymus-Dependent Lymphocytes|thymus derived lymphocyte	A thymocyte-derived lymphocyte of immunological importance that is long-lived (months to years) and is responsible for cell-mediated immunity. T lymphocyte cells form rosettes with sheep erythrocytes and, in the presence of transforming agents (mitogens), differentiate and divide. These cells have the characteristic T3 surface marker and may be further divided into subsets according to function, such as helper, cytotoxic, etc.
C23411	Mouse_Astrocytes	Retired_Concepts	Murine Astrocytes|Astrocytes|Astrocytus|Astroglia|astrocyte	The largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the blood brain barrier. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with microglia) respond to injury. Astrocytes have high- affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitter, but their role in signaling (as in many other functions) is not well understood.
C23412	Mouse_Clear_Cells	Retired_Concepts	Murine Clear Cells|Clear Cells|clear cell
C23413	Mouse_Ductal_Cells	Retired_Concepts	Murine Ductal Cells|Ductal Cells|ductal
C23414	Mouse_Terminal_Ductal_Lobular_Units	Retired_Concepts	Murine Terminal Ductal Lobular Units|TDLU|Terminal Ductal Lobular Units|terminal ductal lobular units
C23415	Mouse_Endothelium	Retired_Concepts	Murine Endothelium|Endothelium|endothelium	A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.
C23416	Mouse_Fibroblasts	Retired_Concepts	Murine Fibroblasts|Fibroblasts|fibroblast	Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
C23417	Mouse_Granular_Cell	Retired_Concepts	Murine Granular Cell|Granular Cell|granular cell
C23418	Mouse_Large_Cell	Retired_Concepts	Murine Large Cell|Large Cell|large cell
C23419	Mouse_Neuroendocrine_Cells	Retired_Concepts	Murine Neuroendocrine Cells|Neuroendocrine Cells|neuroendocrine
C23420	Mouse_Plasma_Cells	Retired_Concepts	Murine Plasma Cells|Blood plasma cell|Plasma Cells|Plasmacytes|Plasmocyte|plasma cell	Specialized forms of antibody-producing B-LYMPHOCYTES. They synthesize and secrete immunoglobulin. They are found only in lymphoid organs and at sites of immune responses and normally do not circulate in the blood or lymph. (Rosen et al., Dictionary of Immunology, 1989, p169 & Abbas et al., Cellular and Molecular Immunology, 2d ed, p20)
C23421	Mouse_Signet_Ring_Cells	Retired_Concepts	Murine Signet Ring Cells|Signet Ring Cells|signet ring cell
C23422	Mouse_Small_Cells	Retired_Concepts	Murine Small Cells|Small Cells|small cell
C23423	Mouse_Spindle_Cell	Retired_Concepts	Murine Spindle Cell|Spindle Cell|spindle cell
C23424	Mouse_Stroma	Retired_Concepts	Murine Stroma|Stroma|stroma	The supporting connective tissue of an organ. (see also parenchyma)
C23425	Mouse_Intrathoracal	Retired_Concepts	Murine Intrathoracal|Intrathoracal
C23426	Mouse_Intraabdominal	Retired_Concepts	Murine Intraabdominal|Intraabdominal
C23427	Mouse_Base_of_Skull	Retired_Concepts	Murine Base of Skull|Base of Skull	The inferior region of the skull consisting of an internal (cerebral), and an external (basilar) surface.
C23428	Mouse_Clivus	Retired_Concepts	Murine Clivus|Clivus
C23429	Mouse_Foramen_Magnum	Retired_Concepts	Murine Foramen Magnum|Foramen Magnum
C23430	Mouse_Jugular_Foramen	Retired_Concepts	Murine Jugular Foramen|Jugular Foramen|Posterior Lacerate Foramen
C23431	Mouse_Sella_Turcica	Retired_Concepts	Murine Sella Turcica|Sella Turcica	A bony prominence situated on the upper surface of the body of the sphenoid bone. It houses the PITUITARY GLAND.
C23432	Mouse_External_Auditory_Canal	Retired_Concepts	Murine External Auditory Canal|Auditory Canal, External|External Auditory Canal	That part of the ear canal external to the ear drum
C23433	Mouse_Inner_Ear	Retired_Concepts	Murine Inner Ear|Inner Ear	The internal ear; the essential part of the organ of hearing. It consists of an osseous and a membranous portion.
C23434	Mouse_Eustachian_Tube	Retired_Concepts	Murine Eustachian Tube|Auditory Tube|Eustachian Tube|Pharyngotympanic Tube|Tuba Auditoria	A tubular structure that runs from the middle ear to the nasopharynx and is approximately 3-4 cm length. Its lumen is roughly triangular and has average diameter of 2-3 mm. The lumen is lined by ciliated pseudostratified, columnar epithelium, which sweeps material from the middle ear to the nasopharynx.  functionally collapsed at rest, with slight negative pressure present in the middle ear. It is closed at rest and opens during swallowing, sneezing, and yawning.  It serves to ventilate pressure differences between the middle ear and nasopharynx. This tube also allows middle ear secretions to drain into the nasopharynx.
C23435	Mouse_Internal_Auditory_Canal	Retired_Concepts	Murine Internal Auditory Canal|Internal Auditory Canal|Internal Auditory Meatus
C23436	Mouse_Tympanic_Membrane	Retired_Concepts	Murine Tympanic Membrane|Ear Drum|Eardrum|Membrana Tympanica|Membrane, Tympanic|TM - Tympanic Membrane|Tympanic Membrane	A thin membrane that separates the external auditory canal from the middle ear.  The movement of the tympanic membrane in response to air pressure changes in the external ear facilitates the transmission of sound energy by causing vibration of the ossicular chain.
C23437	Mouse_Mastoid	Retired_Concepts	Murine Mastoid|Mastoid|Mastoid Process|Process Mastoideus	A honeycombed section of bone located near the base of the skull, protruding behind the outer ear.  It is connected to the middle ear.
C23438	Mouse_Buccal_Cavity	Retired_Concepts	Murine Buccal Cavity|Buccal Cavity|Oral Cavity
C23439	Mouse_Buccal_Mucosa	Retired_Concepts	Murine Buccal Mucosa|Buccal Mucosa
C23440	Mouse_Tooth	Retired_Concepts	Murine Tooth|Teeth|Tooth	is an organ, the organ parts of which primarily consist of dentine and dental enamel; together with other teeth it constitutes a subdivision of the facial skeleton. Example(s): incisor, molar.
C23441	Mouse_Mantle_Field	Retired_Concepts	Murine Mantle Field|Mantle Field
C23442	Mouse_Cell_Types	Retired_Concepts	Murine Cell Types|Cell|Cell Types	Minute protoplasmic masses that make up organized tissue, consisting of a nucleus which is surrounded by protoplasm which contains the various organelles and is enclosed in the cell or plasma membrane. Cells are the fundamental, structural, and functional units of living organisms. (Dorland, 28th ed)
C23443	Mouse_Infratentorial_Brain	Retired_Concepts	Murine Infratentorial Brain|Infratentorial Brain
C23444	Mouse_Midbrain	Retired_Concepts	Murine Midbrain|Mesencephalon|Midbrain	The uppermost portion of the brainstem located between the pons and the diencephalon.  The midbrain contains the cerebral peduncles, oculomotor, trochlear and red nuclei, substantia nigra and various other nuclei and tracts.
C23445	Mouse_Pons	Retired_Concepts	Murine Pons|Pons	The middle portion of the brainstem located between the midbrain and the medulla oblongata.  The fourth ventricle lies dorsal to the pons which also contains the motor trigeminal nuclei and the abducens nuclei.  The cerebellum contributes a large number of afferent fibers to the pons.
C23446	Mouse_Supratentorial_Brain	Retired_Concepts	Murine Supratentorial Brain|Supratentorial Brain	For most authors, this is the cerebral hemispheres plus the basal ganglia, but most clincians do not include the basal ganglia.
C23447	Mouse_Sagittal_Sinus	Retired_Concepts	Murine Sagittal Sinus|Sagittal Sinus
C23448	Mouse_Inferior_Sagittal_Sinus	Retired_Concepts	Murine Inferior Sagittal Sinus|Inferior Sagittal Sinus|Lesser Sagittal Sinus|Sagittal Sinus, Inferior|Sagittal Sinus, Lesser	An intracranial venous sinus that lies in a midline location along the lower free border of the falx cerebri of the brain. The sinus receives blood from the great cerebral vein and joins the superior sagittal sinus posteriorly. (From Carpenter & Sutin, Human Neuroanatomy, 8th ed, pp 733 {KEV 7-26-99})
C23449	Mouse_Superior_Sagittal_Sinus	Retired_Concepts	Murine Superior Sagittal Sinus|Greater Sagittal Sinus|Sagittal Sinus, Greater|Sagittal Sinus, Superior|Superior Sagittal Sinus	An intracranial venous sinus that lies in a superior and midline location above the interhemispheric fissure along the superior border of the falx cerebri of the brain. The sinus receives blood from the cerebral veins and drains posteriorly into the lateral sinuses of the brain, which in turn drain into the internal jugular veins. (From Carpenter & Sutin, Human Neuroanatomy, 8th ed, pp 733 {KEV 7-26-99})
C23450	Mouse_Intracranial_Nervous_System	Retired_Concepts	Murine Intracranial Nervous System|Intracranial Anatomy|Intracranial Compartment Components|Intracranial Nervous System	The brain, intracranial portions of the cranial nerves, intracranial blood vessels, intracranial meninges and other surrounding and supporting structures contained with the skull cavity.
C23451	Mouse_Intraspinal_Nervous_System	Retired_Concepts	Murine Intraspinal Nervous System|Intraspinal Nervous System
C23452	Mouse_Blastomeres	Retired_Concepts	Murine Blastomeres|Blastocytes|Blastomeres|Embryo stage 2	The undifferentiated cells formed by cleavage of the fertilized ovum. This includes cells in the cleavage, morula, and blastula stages of the embryo.
C23453	Mouse_Blood_Cells	Retired_Concepts	Murine Blood Cells|Blood Cells	One of the cells of the blood, a leukocyte or erythrocyte.  SYN blood corpuscle.
C23454	Mouse_Blood_Platelets	Retired_Concepts	Murine Blood Platelets|Bizzozero's corpuscle/cell|Blood Platelets|Deetjeen's body|Hayem's elementary corpuscle|Marrow platelet|PLT - Platelet|Platelets|Reticuloendothelial System, Platelets|THROMBOCYTE/PLATELET|Thrombocytes
C23455	Mouse_Erythrocytes	Retired_Concepts	Murine Erythrocytes|Blood erythrocyte|Blood normocyte|Erythrocytes|Erythrocytic|Marrow erythrocyte|RBC|RBC - Red blood cell|Red Blood Cells|Red blood corpuscule|Red cell of marrow|Red cells|Reticuloendothelial System, Erythrocytes|blood corpuscles	Red blood cells. Mature erythrocytes are non-nucleated, biconcave disks containing hemoglobin whose function is to transport oxygen.
C23456	Mouse_Abnormal_Red_Blood_Cell	Retired_Concepts	Murine Abnormal Red Blood Cell|631-634 ABNORMAL RED BLOOD CELLS|Abnormal Red Blood Cell|Abnormal red cell, NOS|Erythrocyte abnormality, NOS|Erythrocytes, Abnormal|red cell abnormality
C23457	Mouse_Acanthocytes	Retired_Concepts	Murine Acanthocytes|Acanthocytes|Crenated cell	Erythrocytes with protoplasmic projections giving the cell a thorny appearance.
C23458	Mouse_Megaloblasts	Retired_Concepts	Murine Megaloblasts|Megaloblasts
C23459	Mouse_Spherocytes	Retired_Concepts	Murine Spherocytes|Spherocytes	Small, abnormal spherical red blood cells with more than the normal amount of hemoglobin.
C23460	Mouse_Erythroid_Progenitor_Cells	Retired_Concepts	Murine Erythroid Progenitor Cells|BFU-E|BFU-E - Burst-form unit eryth|BFU-E - Burst-forming unit erythroid|Burst-Forming Units, Erythroid|CFU-E|Colony-Forming Units, Erythroid|Erythroid Precursor Cells|Erythroid Progenitor Cells|Erythropoietic Stem Cells|Progenitor Cells, Erythropoietic|Stem Cells, Erythroid	Committed, erythroid stem cells derived from myeloid stem cells. The progenitor cells develop in two phases: erythroid burst-forming units (BFU-E) followed by erythroid colony-forming units (CFU-E). BFU-E differentiate into CFU-E on stimulation by erythropoietin, and then further differentiate into erythroblasts when stimulated by other factors.
C23461	Mouse_Erythroblasts	Retired_Concepts	Murine Erythroblasts|Erythroblasts|Erythrocytes, Nucleated|NUCLEATED RBCS|Normoblasts|Nucleated red blood cell, NOS|Nucleated red cell, NOS	Immature, nucleated erythrocytes occupying the stage of ERYTHROPOIESIS that follows formation of ERYTHROID PROGENITOR CELLS and precedes formation of RETICULOCYTES. Popularly called normoblasts.
C23462	Mouse_Reticulocytes	Retired_Concepts	Murine Reticulocytes|Blood reticulocyte|Diffusely basophilic erythrocyte|Marrow reticulocyte|Polychromatophilic erythrocyte|Reticulocytes	Immature ERYTHROCYTES. In humans, these are erythroid cells that have just undergone extrusion of their CELL NUCLEUS. They still contain some organelles that gradually decrease in number as the cells mature. RIBOSOMES are last to disappear. Certain staining techniques cause components of the ribosomes to precipitate into characteristic "reticulum" (not the same as the endoplasmic reticulum), hence the name reticulocytes.
C23463	Mouse_Leukocytes	Retired_Concepts	Murine Leukocytes|Blood leukocyte|Leukocytes|Marrow leukocyte|Reticuloendothelial System, Leukocytes|WBC|WBC - White blood cell|White Blood Cells|white blood corpuscle	White blood cells. These include granular leukocytes (BASOPHILS, EOSINOPHILS, and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
C23464	Mouse_Granulocytes	Retired_Concepts	Murine Granulocytes|Blood granulocytic cell|Granular Leukocytes|Granulocytes|Granulocytic cell, NOS|Myeloid Cells|granular leukocyte	Leukocytes with abundant granules in the cytoplasm. They are divided into three groups: NEUTROPHILS, EOSINOPHILS, and BASOPHILS.
C23465	Mouse_Basophils	Retired_Concepts	Murine Basophils|Basophils|Blood basophil|Marrow basophil|basophil|basophilic granulocyte|basophilic leukocyte	Granular leukocytes characterized by a relatively pale-staining, lobate nucleus and cytoplasm containing coarse dark-staining granules of variable size and stainable by basic dyes.
C23466	Mouse_Eosinophils	Retired_Concepts	Murine Eosinophils|Blood eosinophil|Eosinophils|Marrow eosinophil|acidophilic leukocyte|eosinocyte|eosinophilic granulocyte|eosinophilic leukocyte	Granular leukocytes with a nucleus that usually has two lobes connected by a slender thread of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin.
C23467	Mouse_Neutrophils	Retired_Concepts	Murine Neutrophils|Blood PMN|Blood neutrophil|Blood segmented neutrophil|Marrow neutrophil|Neutrophils|Polymorph|Polymorphonuclear Leukocytes|Polymorphonuclear neutrophils|heterophil granulocyte|neutrophil|neutrophilic granulocyte|neutrophilic leukocyte
C23468	Mouse_Leukocytes_Mononuclear	Retired_Concepts	Murine Leukocytes, Mononuclear|Agranulocyte|Leukocytes, Mononuclear|Non-Granular Leukocytes	Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
C23469	Mouse_Lymphocytes	Retired_Concepts	Murine Lymphocytes|Blood lymphocyte|Blood lymphocytic cell|Lymphocyte|Lymphocytes|Lymphocytic cell, NOS|Marrow lymphocyte|lymph cell	White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each); those with characteristics of neither major class are called null cells.
C23470	Mouse_Killer_Cells	Retired_Concepts	Murine Killer Cells|Cytotoxic cell|K Cells|K lymphocyte|Killer Cells	Lymphocyte-like effector cells which mediate antibody-dependent cell cytotoxicity. They kill antibody-coated target cells which they bind with their Fc receptors.
C23471	Mouse_CD4-Positive_T-Lymphocytes	Retired_Concepts	Murine CD4-Positive T-Lymphocytes|CD4 lymphocytes|CD4+ T Lymphocytes|CD4-Positive Lymphocytes|CD4-Positive T-Lymphocytes|CELLS.CD4|T4 Cells|T4 Lymphocytes	A critical subpopulation of regulatory T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes, which includes both the helper-inducer (T-LYMPHOCYTES, HELPER-INDUCER) and suppressor-inducer (T-LYMPHOCYTES, SUPPRESSOR-INDUCER) T-cells.
C23472	Mouse_T-Lymphocytes_Helper-Inducer	Retired_Concepts	Murine T-Lymphocytes, Helper-Inducer|Helper Cells|Helper T-Cells|Inducer Cells|T-Cells, Helper-Inducer|T-Lymphocytes, Helper|T-Lymphocytes, Helper-Inducer|T-Lymphocytes, Inducer	Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions.
C23473	Mouse_Th1_Cells	Retired_Concepts	Murine Th1 Cells|Th-1 Cell|Th1 Cells|Type 1 Helper Cell	Subset of helper-inducer T-lymphocytes which synthesize and secrete interleukin-2, gamma-interferon, and interleukin-12. Due to their ability to kill antigen-presenting cells and their lymphokine-mediated effector activity, Th1 cells are associated with vigorous delayed-type hypersensitivity reactions.
C23474	Mouse_Th2_Cells	Retired_Concepts	Murine Th2 Cells|Th-2 Cell|Th2 Cells|Type 2 Helper Cell	Subset of helper-inducer T-lymphocytes which synthesize and secrete the interleukins IL-4, IL-5, IL-6, and IL-10. These cytokines influence B-cell development and antibody production as well as augmenting humoral responses.
C23475	Mouse_T-Lymphocytes_Suppressor-Inducer	Retired_Concepts	Murine T-Lymphocytes, Suppressor-Inducer|T-Cells, Suppressor-Inducer|T-Lymphocytes, Suppressor-Inducer	Subpopulation of CD4+ lymphocytes which induce CD8+ suppressor T-cells (T-LYMPHOCYTES, SUPPRESSOR-EFFECTOR) to suppress antibody production by B-cells. They also stimulate other cellular immune responses.
C23476	Mouse_CD8-Positive_T-Lymphocytes	Retired_Concepts	Murine CD8-Positive T-Lymphocytes|CD8 Cell|CD8 lymphocytes|CD8+ T Lymphocytes|CD8-Positive Lymphocytes|CD8-Positive T-Lymphocytes|CELLS.CD8|T8 Cells|T8 Lymphocytes	A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and suppressor T-lymphocytes (T-LYMPHOCYTES, SUPPRESSOR-EFFECTOR).
C23477	Mouse_T-Lymphocytes_Cytotoxic	Retired_Concepts	Murine T-Lymphocytes, Cytotoxic|CTL|Cell-Mediated Lympholytic Cells|Cytotoxic T-Lymphocytes|T-Lymphocytes, Cytotoxic|cytotoxic T cells	Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These cells are distinct from natural killer cells (KILLER CELLS, NATURAL) and from KILLER CELLS mediating antibody-dependent cell cytotoxicity.
C23478	Mouse_T-Lymphocytes_Suppressor-Effector	Retired_Concepts	Murine T-Lymphocytes, Suppressor-Effector|Suppressor Cells|T suppressor cell|T-Cells, Suppressor-Effector|T-Lymphocytes, Suppressor-Effector|suppressor T lymphocyte	Subpopulation of CD8+ T-lymphocytes which suppress antibody production or inhibit cellular immune responses. Suppressor-effector cells execute the message received from suppressor-inducer cells (T-LYMPHOCYTES, SUPPRESSOR-INDUCER).
C23479	Mouse_Lymphocytes_Null	Retired_Concepts	Murine Lymphocytes, Null|Lymphocytes, Null|Non-B non-T lymphocyte|Non-T non-B cell|Null Cells	A class of lymphocytes characterized by the lack of surface markers specific for either T or B lymphocytes.
C23480	Mouse_Lymphocytes_Tumor-Infiltrating	Retired_Concepts	Murine Lymphocytes, Tumor-Infiltrating|Lymphocytes, Tumor-Infiltrating|TIL|tumor infiltrating lymphocytes	Lymphocytes that show specificity for autologous tumor cells. Ex vivo isolation and culturing of TIL with interleukin-2, followed by reinfusion into the patient, is one form of adoptive immunotherapy of cancer.
C23481	Mouse_Monocytes	Retired_Concepts	Murine Monocytes|Blood monocyte|Marrow monocyte|Monocytes|monocyte	Large, phagocytic mononuclear leukocytes produced in the vertebrate bone marrow and released into the blood; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
C23482	Mouse_Monocytes_Activated_Killer	Retired_Concepts	Murine Monocytes, Activated Killer|Monocytes, Activated Killer	Monocytes made cytotoxic by ex vivo incubation with cytokines, especially interferon-gamma. AKM cells are used for adoptive immunotherapy in cancer patients.
C23483	Mouse_Myeloid_Cells	Retired_Concepts	Murine Myeloid Cells|Myeloid Cells	Cells which include the MONOCYTES and the GRANULOCYTES.
C23484	Mouse_Bone_Marrow_Blood-Forming_Cells	Retired_Concepts	Murine Bone Marrow Blood-Forming Cells|Bone Marrow Blood-Forming Cells|Bone Marrow Cells	Cells contained in the bone marrow including fat cells (see ADIPOCYTES), STROMAL CELLS, MEGAKARYOCYTES, and the immediate precursors of most blood cells.
C23485	Mouse_Hematopoietic_Stem_Cells	Retired_Concepts	Murine Hematopoietic Stem Cells|Blood Precursor Cell|Hematopoietic Progenitor Cells|Hematopoietic Stem Cells|Progenitor Cells, Hematopoietic	Progenitor cells from which all blood cells derive.
C23486	Mouse_Myeloid_Progenitor_Cells	Retired_Concepts	Murine Myeloid Progenitor Cells|Myeloid Progenitor Cells|Stem Cells, Myeloid	One of the two stem cells derived from HEMATOPOIETIC STEM CELLS - the other being the lymphoid progenitor cell. Derived from these myeloid progenitor cells are the ERYTHROID PROGENITOR CELLS and the MYELOID CELLS (MONOCYTES and GRANULOCYTES).
C23487	Mouse_Megakaryocytes	Retired_Concepts	Murine Megakaryocytes|Blood megakaryocyte|Megakaryocytes|megacaryocyte|megalokaryocyte	Very large bone marrow cells which release mature blood platelets.
C23488	Mouse_Chromaffin_Cells	Retired_Concepts	Murine Chromaffin Cells|Chromaffin Cells	Cells that store epinephrine secretory vesicles. During times of stress, the nervous system signals the vesicles to secrete their hormonal content. Their name derives from their ability to stain a brownish color with chromic salts. Characteristically, they are located in the adrenal medulla and paraganglia (PARAGANGLIA, CHROMAFFIN) of the sympathetic nervous system.
C23489	Mouse_Connective_Tissue_Cells	Retired_Concepts	Murine Connective Tissue Cells|Connective Tissue Cells	A group of cells that includes FIBROBLASTS, cartilage cells, ADIPOCYTES, smooth muscle cells, and bone cells.
C23490	Mouse_Adipocytes	Retired_Concepts	Murine Adipocytes|Adipocytes|Adipose cell|Fat Cells|Lipocytes|Mature fat cell	Fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue. Fat is usually stored in the form of TRYGLYCERIDES.
C23491	Mouse_Chondrocytes	Retired_Concepts	Murine Chondrocytes|Chondrocytes	Polymorphic cells that form cartilage.
C23492	Mouse_Macrophages	Retired_Concepts	Murine Macrophages|Macrophage|Macrophages
C23493	Mouse_Epithelioid_Cells	Retired_Concepts	Murine Epithelioid Cells|Epithelioid Cells	Characteristic cells of granulomatous hypersensitivity. They appear as large, flattened cells with increased endoplasmic reticulum. They are believed to be activated macrophages that have differentiated as a result of prolonged antigenic stimulation. Further differentiation or fusion of epithelioid cells is thought to produce multinucleated giant cells (GIANT CELLS).
C23494	Mouse_Foam_Cells	Retired_Concepts	Murine Foam Cells|Foam Cells	Lipid-laden macrophages originating from monocytes or from smooth muscle cells.
C23495	Mouse_Giant_Cells_Foreign-Body	Retired_Concepts	Murine Giant Cells, Foreign-Body|Foreign Body-Type Giant Cells|Giant Cells, Foreign-Body	Multinucleated cells (fused macrophages), characteristic of granulomatous inflammation, which form around exogenous material in the skin. They are similar in appearance to Langhans giant cells (GIANT CELLS, LANGHANS), but foreign-body giant cells have more abundant chromatin and their nuclei are scattered in an irregular pattern in the cytoplasm.
C23496	Mouse_Giant_Cells_Langhans	Retired_Concepts	Murine Giant Cells, Langhans|Giant Cells, Langhans|Langhans-Type Giant Cells	Multinucleated cells (fused macrophages) seen in granulomatous inflammations such as tuberculosis, syphilis, sarcoidosis, and deep fungal infections. They resemble foreign-body giant cells (GIANT CELLS, FOREIGN BODY) but Langhans giant cells contain less chromatin and their nuclei are arranged peripherally in a horseshoe-shaped pattern. Langhans giant cells occur frequently in delayed hypersensitivity.
C23497	Mouse_Histiocytes	Retired_Concepts	Murine Histiocytes|Histiocytes|Histocyte, NOS	A macrophage present in connective tissue.
C23498	Mouse_Kupffer_Cells	Retired_Concepts	Murine Kupffer Cells|Kupffer Cells|Kupffer's cell
C23499	Mouse_Alveolar_Macrophage	Retired_Concepts	Murine Alveolar Macrophage|Alveolar Macrophage|Macrophages, Alveolar|Pulmonary Macrophages	Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.
C23500	Mouse_Peritoneal_Macrophages	Retired_Concepts	Murine Peritoneal Macrophages|Macrophages, Peritoneal|Peritoneal Macrophages	Mononuclear phagocytes derived from bone marrow precursors but resident in the peritoneum.
C23501	Mouse_Odontoblasts	Retired_Concepts	Murine Odontoblasts|Odontoblasts
C23502	Mouse_Osteoblasts	Retired_Concepts	Murine Osteoblasts|Osteoblasts	Bone-forming cells which secrete an EXTRACELLULAR MATRIX. HYDROXYAPATITE crystals are then deposited into the matrix to form bone.
C23503	Mouse_Osteocytes	Retired_Concepts	Murine Osteocytes|Osteocytes	Mature osteoblasts that have become embedded in the BONE MATRIX. They occupy a small cavity, called lacuna, in the matrix and are connected to adjacent osteocytes via protoplasmic projections called canaliculi.
C23504	Mouse_Osteoclasts	Retired_Concepts	Murine Osteoclasts|Osteoclasts	A large multinuclear cell associated with the absorption and removal of bone. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in cementum resorption.
C23505	Mouse_Stromal_Cells	Retired_Concepts	Murine Stromal Cells|Stromal Cells	Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
C23506	Mouse_Theca_Cells	Retired_Concepts	Murine Theca Cells|Ovarian Interstitial Cells|Theca Cells	The connective tissue cells of the ovarian follicle.
C23507	Mouse_Endocrine_Cells_of_Gut	Retired_Concepts	Murine Endocrine Cells of Gut|Endocrine Cells of Gut|Endocrine Cells, Gastrointestinal	Cells found throughout the lining of the gastrointestinal tract that contain regulatory peptide hormones and/or biogenic amines. The substances are located in secretory granules and act in an endocrine or paracrine manner. Some of these substances are also found in neurons in the gut. There are at least 15 different types of endocrine cells of the gut. Some take up amine precursors and have been called APUD CELLS. However, most endocrine cells of the gut apparently have endodermal rather than neuroectodermal origin, so the relationship with APUD cells is not clear.
C23508	Mouse_D_Cells	Retired_Concepts	Murine D Cells|D Cells|Somatostatin Cells	Cells found throughout the gastrointestinal tract and in the pancreas. They secrete somatostatin in both an endocrine and paracrine manner. Somatostatin inhibits gastrin, cholecystokinin, insulin, glucagon, pancreatic enzymes, and gastric hydrochloric acid. A variety of substances which inhibit gastric acid secretion (vasoactive intestinal peptide, calcitonin gene-related peptide, cholecystokinin, beta-adrenergic agonists, and gastric inhibitory peptide) are thought to act by releasing somatostatin.
C23509	Mouse_Enterochromaffin_Cells	Retired_Concepts	Murine Enterochromaffin Cells|Enterochromaffin|Enterochromaffin Cells	Group of basal granular cells of the gut whose granules stain readily with silver and chromium salts. The cells secrete serotonin, substance P, and enkephalins. There are three types: gastric (antral mucosa), duodenal, and intestinal.
C23510	Mouse_Enterochromaffin-like_Cells	Retired_Concepts	Murine Enterochromaffin-like Cells|ECL Cells|Enterochromaffin-like Cells	Irregular-shaped argyrophilic cells which produce histamine, chromogranin A/pancreastatin, and an as yet unidentified peptide hormone. They are the predominant endocrine cell type of the oxyntic (acid-producing) mucosa of the stomach. ECL cells respond to gastrin by releasing their secretory products and this source of histamine acts as the positive paracrine stimulator of the release of hydrochloric acid from the parietal cell.
C23511	Mouse_G_Cells	Retired_Concepts	Murine G Cells|G Cells|Gastrin Cells	Endocrine cells found in the pyloric gland mucosa (antral mucosa) of the stomach and responsible for the secretion of gastrin.
C23512	Mouse_Epithelial_Cells	Retired_Concepts	Murine Epithelial Cells|Epithelial Cells|Epithelial Cells, NOS	Cells that cover the surface of the body and line its cavities.
C23513	Mouse_Ameloblasts	Retired_Concepts	Murine Ameloblasts|Ameloblasts	Cylindrical epithelial cells in the innermost layer of the ENAMEL ORGAN. Their functions include contribution to the development of the dentinoenamel junction by the deposition of a layer of the matrix, thus producing the foundation for the prisms (the structural units of the DENTAL ENAMEL), and production of the matrix for the enamel prisms and interprismatic substance. (From Jablonski's Dictionary of Dentistry, 1992)
C23514	Mouse_Chief_Cells_Gastric	Retired_Concepts	Murine Chief Cells, Gastric|Chief Cells, Gastric|chief cell (stomach)	Epithelial cells that line the basal half of the gastric glands. Chief cells synthesize and secrete pepsinogen, a precursor of the enzyme pepsin.
C23515	Mouse_Chromatophores	Retired_Concepts	Murine Chromatophores|Chromatophores	The large pigment cells of fish, amphibia, reptiles and many invertebrates which actively disperse and aggregate their pigment granules. These cells include MELANOPHORES, erythrophores, xanthophores, leucophores and iridiophores. (In algae, chromatophores refer to CHLOROPLASTS. In phototrophic bacteria chromatophores refer to membranous organelles (BACTERIAL CHROMATOPHORES.)
C23516	Mouse_Melanophores	Retired_Concepts	Murine Melanophores|Melanophores	Chromatophores (large pigment cells of fish, amphibia, reptiles and many invertebrates) which contain melanin. Short term color changes are brought about by an active redistribution of the melanophores pigment containing organelles (MELANOSOMES). Mammals do not have melanophores; however they have retained smaller pigment cells known as MELANOCYTES.
C23517	Mouse_Dendritic_Cell	Retired_Concepts	Murine Dendritic Cell|Dendritic Cell|Dendritic Cells|Interdigitating Cells|Veiled Cells	Dendritic Cells are immunocompetent cells of the lymphoid and hemopoietic systems and skin. They function morphologically and phenotypically by presenting or processing antigens, thereby stimulating cellular immunity. They represent the most potent antigen-presenting cells and, therefore, play a critical role in the primary T cell immune response.
C23518	Mouse_Langerhans_Cells	Retired_Concepts	Murine Langerhans Cells|Langerhans Cells	Dendritic clear cells in the epidermis, containing distinctive granules that appear rod- or racket-shaped in section, but lacking tonofilaments, melanosomes, and desmosomes; they carry surface receptors for immunoglobulin (Fc) and complement (C3), and are believed to be antigen fixing and processing cells of monocytic origin; active participants in cutaneous delayed hypersensitivity.
C23519	Mouse_Enterocytes	Retired_Concepts	Murine Enterocytes|Enterocytes	Terminally differentiated cells comprising the majority of the external surface of the intestinal epithelium (see INTESTINAL MUCOSA). Unlike GOBLET CELLS, they do not produce or secrete mucins, nor do they secrete cryptdins as do the PANETH CELLS.
C23520	Mouse_Goblet_Cells	Retired_Concepts	Murine Goblet Cells|Goblet Cells	Cells of the epithelial lining that produce and secrete mucins.
C23521	Mouse_Granulosa_Cells	Retired_Concepts	Murine Granulosa Cells|Granulosa Cells	Cells of the membrana granulosa lining the vesicular ovarian follicle which become luteal cells after ovulation.
C23522	Mouse_Hepatocytes	Retired_Concepts	Murine Hepatocytes|Hepatic Cells|Hepatic parenchymal cell|Hepatocyte|Hepatocytes|Liver Cells	A parenchymal liver cell.
C23523	Mouse_Keratinocytes	Retired_Concepts	Murine Keratinocytes|Keratinocytes	Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
C23524	Mouse_Labyrinth_Supporting_Cells	Retired_Concepts	Murine Labyrinth Supporting Cells|Labyrinth Supporting Cells|Supporting cell of organ of Corti, NOS	Cells forming a framework supporting the organ of Corti. Specific cells are those of Claudius, Deiters and Hensen.
C23525	Mouse_Melanocytes	Retired_Concepts	Murine Melanocytes|Melanocytes	Epidermal dendritic pigment cells which control long-term morphological color changes by alteration in their number or in the amount of pigment they produce and store in the pigment containing organelles called MELANOSOMES. MELANOPHORES are larger cells which do not exist in mammals.
C23526	Mouse_Merkel_Cells	Retired_Concepts	Murine Merkel Cells|Merkel Cells|Merkel's Receptor	Modified epidermal cells located in the stratum basale. They are found mostly in areas where sensory perception is acute, such as the fingertips. Merkel cells are closely associated with an expanded terminal bulb of an afferent myelinated nerve fiber. Do not confuse with Merkel's corpuscle which is a combination of a neuron and and epidermal cell.
C23527	Mouse_Paneth_Cells	Retired_Concepts	Murine Paneth Cells|Paneth Cells	Epithelial cells found in the basal part of the intestinal glands (crypts of Lieberkuhn). Paneth cells synthesize and secrete lysozyme and cryptdins.
C23528	Mouse_Parietal_Cells_Gastric	Retired_Concepts	Murine Parietal Cells, Gastric|Oxyntic Cells|Parietal Cells, Gastric	Cells of the gastric glands which secrete hydrochloric acid and intrinsic factor.
C23529	Mouse_Sertoli_Cells	Retired_Concepts	Murine Sertoli Cells|Sertoli Cells|Sustentacular cell of testis	Supporting cells found in the seminiferous tubules of the testes in mammals. They surround and nourish developing sperm cells. They secrete ANDROGEN-BINDING PROTEIN and establish the blood-testis barrier.
C23530	Mouse_Eukaryotic_Cells	Retired_Concepts	Murine Eukaryotic Cells|Eukaryotic Cells|eukaryote|eukaryotida	Cells of the higher organisms, containing a true nucleus bounded by a nuclear membrane.
C23531	Mouse_Germ_Cells	Retired_Concepts	Murine Germ Cells|Gametes|Germ Cells|Germ-Line Cells|germ cell|initial cell|reproductive cells|sex cell|sexual cell	The germ cells, collectively as distinguished from the somatic cells or soma, are the reproductive cells of the body, specifically, either egg or sperm cells.
C23532	Mouse_Ovum	Retired_Concepts	Murine Ovum|Egg, Unfertilized|Genital System, Female, Fluids, Secretions, Ova|OVA, FLUIDS, SECRETIONS|Ovum|egg/ovum	A female germ cell extruded from the OVARY at OVULATION.
C23533	Mouse_Oocytes	Retired_Concepts	Murine Oocytes|Oocytes|Ovocytes|oocyte (cell)	Female germ cells in stages between the prophase of the first maturation division and the completion of the second maturation division.
C23534	Mouse_Oogonia	Retired_Concepts	Murine Oogonia|Oogonia|Primary oocyte|Primordial ovum|oogonium (cell)	The primitive differentiated female gametes which give rise to oocytes.
C23535	Mouse_Zygote	Retired_Concepts	Murine Zygote|Egg, Fertilized|Fertilized Egg|Fertilized Ovums|Ovum, Fertilized|Zygote	The fertilized ovum.
C23536	Mouse_Spermatozoa	Retired_Concepts	Murine Spermatozoa|Sperm|Spermatozoa|zoosperm	Mature male germ cells that develop in the seminiferous tubules of the testes. Each consists of a head, a body, and a tail that provides propulsion. The head consists mainly of CHROMATIN.
C23537	Mouse_Sperm_Head	Retired_Concepts	Murine Sperm Head|Sperm Head	The anterior, usually ovoid, nucleus-containing part of spermatozoa.
C23538	Mouse_Spermatids	Retired_Concepts	Murine Spermatids|Spermatids|Spermatoblasts|spermid|spermoblast	Male germ cells derived from spermatocytes and developing into spermatozoa.
C23539	Mouse_Spermatocytes	Retired_Concepts	Murine Spermatocytes|Spermatocytes|Spermiocytes	Male germ cells derived from spermatogonia and developing into spermatids.
C23540	Mouse_Spermatogonia	Retired_Concepts	Murine Spermatogonia|SPERMATAGONIA|Spermatogonia|Spermatogonias|Spermatophores|spermatogone|spermatospore|spermigonium|spermospore	The primitive differentiated male gametes which give rise to spermatocytes.
C23541	Mouse_Giant_Cells	Retired_Concepts	Murine Giant Cells|Giant Cells|Multinucleate giant cell, NOS|Multinucleated Giant Cells|Polykaryocytes|Syncytium	Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.
C23542	Mouse_Islets_of_Langerhans	Retired_Concepts	Murine Islets of Langerhans|B9 ENDOCRINE PANCREAS|Islands of Langerhans|Islet Cells|Islets of Langerhans|Nesidioblasts|Pancreas, Endocrine|Pancreatic islets|Pars endocrina pancreatis|pancreatic islet	Irregular microscopic structures, varying from a few to hundreds of cells, scattered throughout the pancreas and comprising its endocrine portion. There are three cell types: alpha, secreting glucagon; beta, secreting insulin; and delta (D CELLS), secreting somatostatin.
C23543	Mouse_Leydig_Cells	Retired_Concepts	Murine Leydig Cells|Interstitial cell of Leydig|Leydig Cells|Testicular Interstitial Cells|interstitial cell|interstitial cells (testicle)	Cells in the interstitial tissue of the testis that are believed to furnish the internal secretion of that gland.
C23544	Mouse_Lutein_Cells	Retired_Concepts	Murine Lutein Cells|Lutein Cells|luteal cell	The cells of the corpus luteum which are derived from the granulosa cells and the theca cells of the Graafian follicle.
C23545	Mouse_Antibody-Producing_Cells	Retired_Concepts	Murine Antibody-Producing Cells|Antibody-Producing Cells|Immunoglobulin-Producing Cells	Cells of the lymphoid series that can react with antigen to produce specific cell products called antibodies. Various cell subpopulations, often B-lymphocytes, can be defined, based on the different classes of immunoglobulins that they synthesize.
C23546	Mouse_Muscle_Cells	Retired_Concepts	Murine Muscle Cells|Muscle Cells
C23547	Mouse_Muscle_Fibers_Fast-Twitch	Retired_Concepts	Murine Muscle Fibers, Fast-Twitch|Muscle Fibers, Fast-Twitch|Muscle Fibers, Type II|Skeletal muscle fiber, type II	Skeletal muscle fibers having high myofibrillar ATPase activity, high glycolytic enzyme activities, and an intermediate glycogen content which produce a fast twitch. There are two types. Fast fatigable fibers, also called white fibers, have a low myoglobin content, and a small mitochondrial content, and fatigue rapidly due to their limited glycogen content and low capacity for oxidative metabolism. Fast fatigue-resistant fibers, also called red fibers, have a large mitochondrial content and a high myoglobin content, related to their resistance to fatigue. (From Best, Physiological Basis of Medical Practice, 12th ed, p100)
C23548	Mouse_Muscle_Fibers_Slow-Twitch	Retired_Concepts	Murine Muscle Fibers, Slow-Twitch|Muscle Fibers, Intermediate|Muscle Fibers, Slow-Twitch|Muscle Fibers, Type I|Skeletal muscle fiber, type I	Skeletal muscle fibers having low myofibrillar ATPase activity, low glycogen content, and high myoglobin content, high mitochondrial oxidative enzyme activities, and an intermediate mitochondrial content which produce a slow twitch and are fatigue-resistant. (From Best, Physiological Basis of Medical Practice, 12th ed, p101)
C23549	Mouse_Neuroglia	Retired_Concepts	Murine Neuroglia|A04 GLIA|Glia|Glial Cells|Kolliker's reticulum|Neuroglia|Neuroglial Cells|Non-neuronal cell|nerve cement	The non-neuronal cells of the nervous system. They are divided into macroglia (ASTROCYTES, OLIGODENDROGLIA, and SCHWANN CELLS) and MICROGLIA. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the blood-brain and blood-retina barriers, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.
C23550	Mouse_Microglia	Retired_Concepts	Murine Microglia|Gitter cell|Hortega cell|Microglia|Microgliocyte|mesoglia|microglial cell|perivascular glial cell	The third type of glial cell, along with astrocytes and oligodendrocytes (which together form the macroglia). Microglia vary in appearance depending on developmental stage, functional state, and anatomical location; subtype terms include ramified, perivascular, ameboid, resting, and activated. Microglia clearly are capable of phagocytosis and play an important role in a wide spectrum of neuropathologies. They have also been suggested to act in several other roles including in secretion (e.g., of cytokines and neural growth factors), in immunological processing (e.g., antigen presentation), and in central nervous system development and remodeling.
C23551	Mouse_Neuropil	Retired_Concepts	Murine Neuropil|Neuropil	A dense intricate feltwork of interwoven fine glial processes, fibrils, synaptic terminals, axons, and dendrites interspersed among the nerve cells in the gray matter of the central nervous system.
C23552	Mouse_Oligodendroglia	Retired_Concepts	Murine Oligodendroglia|Oligodendrocytes|Oligodendrocytus|Oligodendroglia	A class of neuroglial (macroglial) cells in the central nervous system. Oligodendroglia may be called interfascicular, perivascular, or perineuronal satellite cells according to their location. The most important recognized function of these cells is the formation of the insulating myelin sheaths of axons in the central nervous system.
C23553	Mouse_Perineuronal_Satellite_Cell	Retired_Concepts	Murine Perineuronal Satellite Cell|Perineuronal Satellite Cell|Perineuronal satellite cell
C23554	Mouse_Schwann_Cells	Retired_Concepts	Murine Schwann Cells|Neurilemma cell|Schwann Cells	Neuroglial cells of the peripheral nervous system which form the insulating myelin sheaths of peripheral axons.
C23555	Mouse_Antigen-Presenting_Cells	Retired_Concepts	Murine Antigen-Presenting Cells|APC|Antigen-Presenting Cells|Immunologic Accessory Cells|Monocytes / Macrophages / APC|accessory cell	Heterogeneous group of immunocompetent cells that mediates the cellular immune response by processing and presenting antigens to the T-cell receptor. Traditional antigen-presenting cells include MACROPHAGES, DENDRITIC CELLS, LANGERHANS CELLS, and B-LYMPHOCYTES. Follicular dendritic cells (DENDRITIC CELLS, FOLLICULAR) are also considered to be antigen-presenting cells by some authors.
C23556	Mouse_Follicular_Dendritic_Cells	Retired_Concepts	Murine Follicular Dendritic Cells|Dendritic Cells, Follicular|Follicular Dendritic Cells	Antigen Presenting Cells (APCs) located in the follicles of secondary lymphoid organs.  These dendritic cells are unique because of their location, primarily in lymphoid follicles, and because of their function in retaining antigen molecules for extended periods of time and serving as APCs for B cells.
C23557	Mouse_Neurons	Retired_Concepts	Murine Neurons|Nerve Cells|Neurons|nerve unit|neurocyte	Any of the conducting cells of the nervous system. A typical neuron consists of a cell body, containing the nucleus and the surrounding cytoplasm (perikaryon); several short radiating processes (dendrites); and one long process (the axon), which terminates in twiglike branches (telodendrons) and may have branches (collaterals) projecting along its course.
C23558	Mouse_Autonomic_Fibers_Preganglionic	Retired_Concepts	Murine Autonomic Fibers, Preganglionic|Autonomic Fibers, Preganglionic|preganglionic fiber	Nerve fibers which project from the central nervous system to autonomic ganglia. In the sympathetic division most preganglionic fibers originate with neurons in the intermediolateral column of the spinal cord, exit via ventral roots from upper thoracic through lower lumbar segments, and project to the paravertebral ganglia; there they either terminate in synapses or continue through the splanchnic nerves to the prevertebral ganglia. In the parasympathetic division the fibers originate in neurons of the brain stem and sacral spinal cord. In both divisions the principal transmitter is acetylcholine but peptide cotransmitters may also be released.
C23559	Mouse_Interneurons	Retired_Concepts	Murine Interneurons|Intercalated Neurons|Interneurons|connector neuron|intercalary neuron|internuncial cell|internuncial neuron	Most generally any neurons which are not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region as contrasted with projection neurons which have axons projecting to other brain regions.
C23560	Mouse_Amacrine_Cells	Retired_Concepts	Murine Amacrine Cells|Amacrine Cells|Amacrine cells of retina
C23561	Mouse_Nerve_Fibers_Myelinated	Retired_Concepts	Murine Nerve Fibers, Myelinated|Nerve Fibers, Myelinated	AXONS of NEURONS encased in a lipoproteinaceous material called MYELIN. Myelinated nerve fibers conduct impulses more rapidly than unmyelinated nerve fibers.
C23562	Mouse_Neurons_Afferent	Retired_Concepts	Murine Neurons, Afferent|Neurons, Afferent|Neurons, Sensory	Neurons which convey sensory information centrally from the periphery.
C23563	Mouse_Hair_Cells	Retired_Concepts	Murine Hair Cells|Corti cell|Hair Cells|ear hair cell	Mechanoreceptors located in the organ of Corti that are sensitive to auditory stimuli and in the vestibular apparatus that are sensitive to movement of the head. In each case the accessory sensory structures are arranged so that appropriate stimuli cause movement of the hair-like projections (stereocilia and kinocilia) which relay the information centrally in the nervous system.
C23564	Mouse_Hair_Cells_Inner	Retired_Concepts	Murine Hair Cells, Inner|Hair Cells, Inner	Bulbous cells that are medially placed in one row in the organ of Corti. In contrast to the outer hair cells, the inner hair cells are fewer in number, have fewer sensory hairs, and are less differentiated.
C23565	Mouse_Hair_Cells_Outer	Retired_Concepts	Murine Hair Cells, Outer|Hair Cells, Outer	Mechanoreceptors in the organ of Corti. In mammals the outer hair cells are arranged in three rows which are further from the modiolus than the single row of inner hair cells. The motile properties of the outer hair cells may contribute actively to tuning the sensitivity and frequency selectivity of the cochlea.
C23566	Mouse_Hair_Cells_Vestibular	Retired_Concepts	Murine Hair Cells, Vestibular|Hair Cells, Vestibular|equilibrium hair cell	Mechanoreceptors located in the acoustic maculae and the semicircular canals that mediate the sense of balance, movement, and head position. The vestibular hair cells are connected to accessory structures in such a way that movements of the head displace their stereocilia. This influences the membrane potential of the cells which relay information about movements via the vestibular part of the VESTIBULOCOCHLEAR NERVE to the brain stem.
C23567	Mouse_Olfactory_Receptor_Neurons	Retired_Concepts	Murine Olfactory Receptor Neurons|Olfactory Receptor Neurons	Neurons in the olfactory epithelium with proteins (RECEPTORS, ODORANT) that bind, and thus detect, odorants. Olfactory receptor neurons are bipolar. They send to the surface of the epithelium apical dendrites with non-motile cilia from which project odorant receptor molecules. Their unmyelinated axons synapse in the olfactory bulb of the brain. Unlike other neurons, they can be generated from precursor cells in adults.
C23568	Mouse_Photoreceptors	Retired_Concepts	Murine Photoreceptors|Photoreceptors|visual receptor	Cells specialized to detect and transduce light.
C23569	Mouse_Photoreceptors_Invertebrate	Retired_Concepts	Murine Photoreceptors, Invertebrate|Photoreceptors, Invertebrate	Cells in invertebrates which are specialized to detect and transduce light and darkness and relay that information centrally in the nervous system.
C23570	Mouse_Photoreceptors_Vertebrate	Retired_Concepts	Murine Photoreceptors, Vertebrate|Photoreceptors, Vertebrate|Rods and Cones	Cells specialized to detect and transduce light. Rods and cones are the photoreceptors in the vertebrate retina.
C23571	Mouse_Cones_Retina	Retired_Concepts	Murine Cones (Retina)|Cones|Cones (Eye)|Cones (Retina)|Photoreceptors, Cone|cone cell|retinal cone	One of the two photoreceptor cell types in the vertebrate retina. In cones the photopigment is in invaginations of the cell membrane of the outer segment. Cones are less sensitive to light than rods, but they provide vision with higher spatial and temporal acuity, and the combination of signals from cones with different pigments allows color vision.
C23572	Mouse_Rods_Retina	Retired_Concepts	Murine Rods (Retina)|Rod Photoreceptors|Rods|Rods (Eye)|Rods (Retina)|rod cell	One of the two photoreceptor cell types of the vertebrate retina. In rods the photopigment is in stacks of membranous disks separate from the outer cell membrane. Rods are more sensitive to light than cones, but rod mediated vision has less spatial and temporal resolution than cone vision.
C23573	Mouse_Rod_Outer_Segments	Retired_Concepts	Murine Rod Outer Segments|ROS (rod outer segment)|Rod Outer Segments	The portion of the retinal rod cell between the inner segment and the pigment epithelium layer of the retina.
C23574	Mouse_Posterior_Horn_Cells	Retired_Concepts	Murine Posterior Horn Cells|Dorsal Horn Cells|Neurons, Dorsal Horn|Neurons, Posterior Horn|Posterior Horn Cells	Neurons in the posterior (dorsal) horn of the spinal cord whose cell bodies and processes are confined entirely to the central nervous system. They receive collateral or direct terminations of dorsal root fibers. They send their axons either directly to ANTERIOR HORN CELLS or to the white matter ascending and descending longitudinal fibers.
C23575	Mouse_Substantia_Gelatinosa	Retired_Concepts	Murine Substantia Gelatinosa|Substantia Gelatinosa|Substantia gelatinosa of Rolando	Gelatinous-appearing material in the dorsal horn of the spinal cord, consisting chiefly of Golgi type II neurons and some larger nerve cells.
C23576	Mouse_Retinal_Ganglion_Cells	Retired_Concepts	Murine Retinal Ganglion Cells|Ganglion Cells (Retina)|Retinal Ganglion Cells|retinal ganglion	Cells of the innermost nuclear layer of the retina, the ganglion cell layer, which project axons through the optic nerve to the brain. They are quite variable in size and in the shapes of their dendritic arbors, which are generally confined to the inner plexiform layer.
C23577	Mouse_Neurons_Efferent	Retired_Concepts	Murine Neurons, Efferent|Neurons, Efferent|efferent nerve	Neurons which send impulses peripherally to activate muscles or secretory cells.
C23578	Mouse_Motor_Neurons	Retired_Concepts	Murine Motor Neurons|Motoneuron|Motor Neurons|motor cell	Neurons which activate muscle cells.
C23579	Mouse_Anterior_Horn_Cells	Retired_Concepts	Murine Anterior Horn Cells|Anterior Horn Cells|Neurons, Anterior Horn|Ventral Horn Cells|Ventral Horn Neurons	Motor neurons in the anterior (ventral) horn of the spinal cord which project to skeletal muscles.
C23580	Mouse_Motor_Neurons_Gamma	Retired_Concepts	Murine Motor Neurons, Gamma|Motor Neurons, Gamma|Motor Neurons, Gamma-Efferent|Neurons, Fusimotor	Motor neurons which activate the contractile regions of intrafusal muscle fibers, thus adjusting the sensitivity of the muscle spindles to stretch. Gamma motor neurons may be "static" or "dynamic" according to which aspect of responsiveness (or which fiber types) they regulate. The alpha and gamma motor neurons are often activated together (alpha gamma coactivation) which allows the spindles to contribute to the control of movement trajectories despite changes in muscle length.
C23581	Mouse_Nitrergic_Neurons	Retired_Concepts	Murine Nitrergic Neurons|Nitrergic Neurons|Nitroxidergic Neurons
C23582	Mouse_Autonomic_Fibers_Postganglionic	Retired_Concepts	Murine Autonomic Fibers, Postganglionic|Autonomic Fibers, Postganglionic|postganglionic fiber	Nerve fibers which project from cell bodies of autonomic ganglia to synapses on target organs.
C23583	Mouse_Parasympathetic_Fibers_Postganglionic	Retired_Concepts	Murine Parasympathetic Fibers, Postganglionic|Parasympathetic Fibers, Postganglionic	Nerve fibers which project from parasympathetic ganglia to synapses on target organs. Parasympathetic postganglionic fibers use acetylcholine as transmitter. They may also release peptide cotransmitters.
C23584	Mouse_Sympathetic_Fibers_Postganglionic	Retired_Concepts	Murine Sympathetic Fibers, Postganglionic|Sympathetic Fibers, Postganglionic	Nerve fibers which project from sympathetic ganglia to synapses on target organs. Sympathetic postganglionic fibers use norepinephrine as transmitter, except for those innervating eccrine sweat glands (and possibly some blood vessels) which use acetylcholine. They may also release peptide cotransmitters.
C23585	Mouse_Purkinje_Cells	Retired_Concepts	Murine Purkinje Cells|Purkinje Cells|Purkinje's corpuscles|cerebellar Purkinje cell	The output neurons of the cerebellar cortex.
C23586	Mouse_Pyramidal_Cells	Retired_Concepts	Murine Pyramidal Cells|Pyramidal Cells	Projection neurons in the cerebral cortex and the hippocampus. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region.
C23587	Mouse_Senile_Plaques	Retired_Concepts	Murine Senile Plaques|Amyloid Plaques|Neuritic Plaques|Senile Plaques	Spherical masses consisting of amyloid fibrils and neuronal processes.
C23588	Mouse_Oxyphil_Cells	Retired_Concepts	Murine Oxyphil Cells|Askenazy Cells|Hurthle Cells|Oncocytes|Oxyphil Cells
C23589	Mouse_APUD_Cells	Retired_Concepts	Murine APUD Cells|APUD Cells	Cells derived from primitive cell types in the neural crest. During ontogeny they migrate to the foregut and specific locations of the neuroendocrine system. Properly located these cells form part of the normal hormone producing tissues of the neuroendocrine system. If misdirected these cells may become hyperplastic, adenomatous, or malignant (cf. APUDOMA).
C23590	Mouse_Pericytes	Retired_Concepts	Murine Pericytes|Pericytes|Rouget Cells	Slender, contractile, mesenchymal-like cells found in close association with capillary walls. They are relatively undifferentiated and may become fibroblasts, macrophages, or smooth muscle cells. (From Stedman, 26th ed)
C23591	Mouse_Phagocytes	Retired_Concepts	Murine Phagocytes|Phagocytes|Phagocytic cell, NOS|amebocyte
C23592	Mouse_Reed-Sternberg_Cells	Retired_Concepts	Murine Reed-Sternberg Cells|Reed-Sternberg Cells	Large cells of unknown origin, usually multinucleate, whose presence is the common histologic characteristic of HODGKIN DISEASE.
C23593	Mouse_Stem_Cells	Retired_Concepts	Murine Stem Cells|Ferrata cell|Hematohistioblast|Hemocytoblast|Hemohistioblast|Mother Cells|Progenitor Cells|Stem Cells	Primitive blood cells derived from embryonic mesenchyme capable of differentiating into any of the blood cell line progenitor cells (erythroblasts, young granulocytic series cells, megakaryocytes, etc.)
C23594	Mouse_Tumor_Stem_Cells	Retired_Concepts	Murine Tumor Stem Cells|Colony-Forming Units, Neoplastic|Stem Cells, Neoplastic|Tumor Stem Cells	Colony-forming cells which give rise to neoplasms.
C23595	Mouse_Abdomen	Retired_Concepts	Murine Abdomen|Abdomen|Abdomen, NOS	That portion of the body that lies between the thorax and the pelvis.
C23596	Mouse_Abducens_Nerve	Retired_Concepts	Murine Abducens Nerve|Abducens Nerve|Cranial Nerve VI|Nervus Abducens|Sixth Cranial Nerve	The 6th cranial nerve. The abducens nerve originates in the abducens nucleus of the pons and sends motor fibers to the lateral rectus muscles of the eye. Damage to the nerve or its nucleus disrupts horizontal eye movement control.
C23597	Mouse_Adrenal_Gland	Retired_Concepts	Murine Adrenal Gland|Adrenal|Adrenal Gland|Adrenal gland, NOS|Adrenal glands|adrenal gland
C23598	Mouse_Anterior_Chamber_of_Eye	Retired_Concepts	Murine Anterior Chamber of Eye|Anterior Chamber|Anterior Chamber (Eye)|Anterior Chamber of Eye|Chamber, Anterior	The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)
C23599	Mouse_Anterior_Eye_Segment	Retired_Concepts	Murine Anterior Eye Segment|Anterior Eye Segment	That part of the eyeball anterior to the lens.
C23600	Mouse_Aorta	Retired_Concepts	Murine Aorta|Aorta	The main trunk of the systemic arteries.
C23601	Mouse_Aortic_Valve	Retired_Concepts	Murine Aortic Valve|Aortic Valve	The valve between the left ventricle and the ascending aorta which prevents backflow into the left ventricle.
C23602	Mouse_Upper_Extremity	Retired_Concepts	Murine Upper Extremity|Upper Extremity|Upper limb, NOS|forelimb
C23603	Mouse_Arteriole	Retired_Concepts	Murine Arteriole|Arteriole	The smallest divisions of the arteries located between the muscular arteries and the capillaries.
C23604	Mouse_Autonomic_Nervous_System	Retired_Concepts	Murine Autonomic Nervous System|Autonomic Nervous System	The enteric, parasympathetic, and sympathetic nervous systems taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the central nervous system, especially the hypothalamus and the solitary nucleus, which receive information relayed from VISCERAL AFFERENTS; these and related central and sensory structures are sometimes (but not here) considered to be part of the autonomic nervous system itself.
C23605	Mouse_Axilla	Retired_Concepts	Murine Axilla|Armpit|Axilla|Underarm
C23606	Mouse_Bartholin_s_Gland	Retired_Concepts	Murine Bartholin's Gland|Bartholin's Gland	Mucus-secreting glands situated on the posterior and lateral aspect of the vestibule of the vagina.
C23607	Mouse_Basilar_Artery	Retired_Concepts	Murine Basilar Artery|Basilar Artery	The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.
C23608	Mouse_Intrahepatic_Bile_Duct	Retired_Concepts	Murine Intrahepatic Bile Duct|Intrahepatic Bile Duct	Passages within the liver for the conveyance of bile. Includes right and left hepatic ducts even though these may join outside the liver to form the common hepatic duct.
C23609	Mouse_Biliary_Tract	Retired_Concepts	Murine Biliary Tract|Biliary Tract|Tract, Biliary	The gallbladder and its ducts.
C23610	Mouse_Blood_Vessel	Retired_Concepts	Murine Blood Vessel|Blood Vessel|Blood vessel	Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
C23611	Mouse_Body_Region	Retired_Concepts	Murine Body Region|Body Region	Anatomical areas of the body.
C23612	Mouse_Brachial_Artery	Retired_Concepts	Murine Brachial Artery|Brachial Artery	The continuation of the axillary artery; it branches into the radial and ulnar arteries.
C23613	Mouse_Brachial_Plexus	Retired_Concepts	Murine Brachial Plexus|Brachial Plexus	The large network of nerve fibers which distributes the innervation of the upper extremity. The brachial plexus extends from the neck into the axilla. In humans, the nerves of the plexus usually originate from the lower cervical and the first thoracic spinal cord segments (C5-C8 and T1), but variations are not uncommon.
C23614	Mouse_Bronchus	Retired_Concepts	Murine Bronchus|Bronchi|Bronchus	The larger air passages of the lungs arising from the terminal bifurcation of the trachea.
C23615	Mouse_Bronchioles	Retired_Concepts	Murine Bronchioles|Bronchioles
C23616	Mouse_Capillary	Retired_Concepts	Murine Capillary|Capillary	The minute vessels that connect the arterioles and venules.
C23617	Mouse_Cardiovascular_System	Retired_Concepts	Murine Cardiovascular System|Cardiovascular System|Cardiovascular system (all sites)|Vascular, Heart|cardiovascular
C23618	Mouse_Carotid_Artery	Retired_Concepts	Murine Carotid Artery|Carotid Artery	Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
C23619	Mouse_Carpal_Bone	Retired_Concepts	Murine Carpal Bone|Carpal Bone	The eight bones of the wrist: capitate bone, hamate bone, lunate bone (SEMILUNAR BONE), pisiform bone, SCAPHOID BONE, trapezium bone, trapezoid bone and triquetral bone.
C23620	Mouse_Cauda_Equina	Retired_Concepts	Murine Cauda Equina|Cauda Equina|Cauda equina	The lower part of the SPINAL CORD consisting of the lumbar, sacral, and coccygeal nerve roots.
C23621	Mouse_Cavernous_Sinus	Retired_Concepts	Murine Cavernous Sinus|Cavernous Sinus	An irregularly shaped venous space in the dura mater at either side of the sphenoid bone.
C23622	Mouse_Cerebral_Arteries	Retired_Concepts	Murine Cerebral Arteries|Cerebral Arteries	The arteries supplying the cerebral cortex.
C23623	Mouse_Cerebrospinal_Fluid	Retired_Concepts	Murine Cerebrospinal Fluid|CSF|Cerebrospinal Fluid|cerebrospinal fluid	The body fluid.
C23624	Mouse_Cervical_Vertebrae	Retired_Concepts	Murine Cervical Vertebrae|Cervical Vertebrae
C23625	Mouse_Choroid_Plexus	Retired_Concepts	Murine Choroid Plexus|Choroid Plexus	A villous structure of tangled masses of BLOOD VESSELS contained within the third, lateral, and fourth ventricles of the BRAIN. It regulates part of the production and composition of CEREBROSPINAL FLUID.
C23626	Mouse_Clavicle	Retired_Concepts	Murine Clavicle|Clavicle|Collar Bone
C23627	Mouse_Coccyx	Retired_Concepts	Murine Coccyx|Coccyx
C23628	Mouse_Cochlear_Nerve	Retired_Concepts	Murine Cochlear Nerve|Cochlear Nerve|Cochlear Root of Acoustic Nerve|Cochlear Root of Eighth Cranial Nerve	The cochlear part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The cochlear nerve fibers originate from neurons of the SPIRAL GANGLION and project peripherally to cochlear hair cells and centrally to the cochlear nuclei (COCHLEAR NUCLEUS) of the BRAIN STEM. They mediate the sense of hearing.
C23629	Mouse_Common_Bile_Duct	Retired_Concepts	Murine Common Bile Duct|Common Bile Duct|common bile duct	Bile ducts are passageways that carry bile. Two major bile ducts come together into a "trunk"-the common bile duct which empties into the upper part of the small intestine (the part next to the stomach).
C23630	Mouse_Corneal_Stroma	Retired_Concepts	Murine Corneal Stroma|Corneal Stroma	The lamellated connective tissue constituting the thickest layer of the cornea between the Bowman and Descemet membranes.
C23631	Mouse_Cranial_Nerve	Retired_Concepts	Murine Cranial Nerve|Cranial Nerve|Cranial nerve, NOS|cranial nerve
C23632	Mouse_Dermis	Retired_Concepts	Murine Dermis|Dermis	A layer of vascular connective tissue underneath the EPIDERMIS. The surface of the dermis contains sensitive papillae. Embedded in or beneath the dermis are SWEAT GLANDS, hair follicles, and SEBACEOUS GLANDS.
C23633	Mouse_Diaphragm	Retired_Concepts	Murine Diaphragm|Diaphragm	The musculofibrous partition that separates the thoracic cavity from the abdominal cavity. Contraction of the diaphragm increases the volume of the thoracic cavity aiding inspiration.
C23634	Mouse_Ectoderm	Retired_Concepts	Murine Ectoderm|Ectoderm	The outer of the three germ layers of the embryo.
C23635	Mouse_Endocrine_Gland	Retired_Concepts	Murine Endocrine Gland|ENDOCRINE ORGANS|Endocrine Gland|Endocrine gland, NOS	Ductless glands that secrete substances which are released directly into the circulation and which influence metabolism and other body functions.
C23636	Mouse_Endocrine_System	Retired_Concepts	Murine Endocrine System|Endocrine|Endocrine System|Endocrine system|Endocrine system (all sites)|Hormonal System	The system of glands that release their secretions (hormones) directly into the circulatory system. In addition to the ENDOCRINE GLANDS, included are the CHROMAFFIN SYSTEM and the NEUROSECRETORY SYSTEMS.
C23637	Mouse_Endoderm	Retired_Concepts	Murine Endoderm|Endoderm	The inner of the three germ layers of the embryo.
C23638	Mouse_Corneal_Endothelium	Retired_Concepts	Murine Corneal Endothelium|Corneal Endothelium	Single layer of large flattened cells covering the surface of the cornea.
C23639	Mouse_Epidermis	Retired_Concepts	Murine Epidermis|Epidermis
C23640	Mouse_Epiglottis	Retired_Concepts	Murine Epiglottis|Epiglottis	Thin leaf-shaped cartilage, covered with mucous membrane, at the root of the tongue, which folds back over the entrance to the larynx, covering it, during the act of swallowing.
C23641	Mouse_Epithelium	Retired_Concepts	Murine Epithelium|Epithelium|epithelium	One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
C23642	Mouse_Ethmoid_Bone	Retired_Concepts	Murine Ethmoid Bone|Ethmoid Bone
C23643	Mouse_Exocrine_Gland	Retired_Concepts	Murine Exocrine Gland|Exocrine Gland	A gland from which secretions reach a free surface of the body by ducts.
C23644	Mouse_Eyelid	Retired_Concepts	Murine Eyelid|Eyelid|Palpebra
C23645	Mouse_Facial_Nerve	Retired_Concepts	Murine Facial Nerve|Facial Nerve	The 7th cranial nerve. The facial nerve has two parts, the larger motor root which may be called the facial nerve proper, and the smaller intermediate or sensory root. Together they provide efferent innervation to the muscles of facial expression and to the lacrimal and salivary glands, and convey afferent information for taste from the anterior two-thirds of the tongue and for touch from the external ear.
C23646	Mouse_Femoral_Artery	Retired_Concepts	Murine Femoral Artery|Femoral Artery	The main artery of the thigh, a continuation of the external iliac artery.
C23647	Mouse_Femoral_Vein	Retired_Concepts	Murine Femoral Vein|Femoral Vein	The vein accompanying the femoral artery in the same sheath; it is a continuation of the popliteal vein and becomes the external iliac vein.
C23648	Mouse_Femur	Retired_Concepts	Murine Femur|Femur	The longest and largest bone of the skeleton, it is situated between the hip and the knee.
C23649	Mouse_Fibula	Retired_Concepts	Murine Fibula|Fibula	The bone of the lower leg lateral to and smaller than the tibia. In proportion to its length, it is the most slender of the long bones.
C23650	Mouse_Ganglia	Retired_Concepts	Murine Ganglia|Ganglia|Neural Ganglion	Clusters of multipolar neurons surrounded by a capsule of loosely organized CONNECTIVE TISSUE located outside the CENTRAL NERVOUS SYSTEM.
C23651	Mouse_Autonomic_Ganglia	Retired_Concepts	Murine Autonomic Ganglia|Autonomic Ganglia	Clusters of neurons and their processes in the autonomic nervous system. In the autonomic ganglia, the preganglionic fibers from the central nervous system synapse onto the neurons whose axons are the postganglionic fibers innervating target organs. The ganglia also contain intrinsic neurons and supporting cells and preganglionic fibers passing through to other ganglia.
C23652	Mouse_Geniculate_Ganglion	Retired_Concepts	Murine Geniculate Ganglion|Facial Nerve Ganglion|Genicular Ganglion|Geniculate Ganglion	The sensory ganglion of the facial (7th cranial) nerve. The geniculate ganglion cells send central processes to the brain stem and peripheral processes to the taste buds in the anterior tongue, the soft palate, and the skin of the external auditory meatus and the mastoid process.
C23653	Mouse_Male_Reproductive_System	Retired_Concepts	Murine Male Reproductive System|Genital System, Male|Male Reproductive System|Penis and Other Genital|Reproductive System, Male|male genital	The male reproductive organs. They are divided into the external organs (penis, scrotum, and urethra) and the internal organs (testis, epididymis, ductus deferens, seminal vesicle, ejaculatory duct, prostate, and bulbourethral gland.
C23654	Mouse_Glossopharyngeal_Nerve	Retired_Concepts	Murine Glossopharyngeal Nerve|Cranial Nerve IX|Glossopharyngeal Nerve|Nervus Glossopharyngeus|Ninth Cranial Nerve	The 9th cranial nerve. The glossopharyngeal nerve is a mixed motor and sensory nerve; it conveys somatic and autonomic efferents as well as general, special, and visceral afferents. Among the connections are motor fibers to the stylopharyngeus muscle, parasympathetic fibers to the parotid glands, general and taste afferents from the posterior third of the tongue, the nasopharynx, and the palate, and afferents from baroreceptors and chemoreceptors of the carotid sinus.
C23655	Mouse_Glottis	Retired_Concepts	Murine Glottis|Glottis	The vocal apparatus of the larynx, consisting of the true vocal cords (plica vocalis) and the opening between them (rima glottidis).
C23656	Mouse_Gonads	Retired_Concepts	Murine Gonads|Gonads|gonad	The gamete-producing glands, OVARY or TESTIS.
C23657	Mouse_Groin	Retired_Concepts	Murine Groin|Groin|groin	The external junctural region between the lower part of the abdomen and the thigh.
C23658	Mouse_Heart	Retired_Concepts	Murine Heart|Heart|heart
C23659	Mouse_Cardiac_Atria	Retired_Concepts	Murine Cardiac Atria|Atria of Heart|Atria, Cardiac|Atrium of Heart|Cardiac Atria|Cardiac Atrium|Heart Atria|Heart Atrium	The paired upper chambers of the heart.  The left atrium receives oxygenated blood from the pulmonary vein and pumps blood into the left ventricle.  The right atrium receives venous deoxygenated blood from the entire body via the superior and inferior vena cavae and pumps blood into the right ventricle.
C23660	Mouse_Cardiac_Valves	Retired_Concepts	Murine Cardiac Valves|Cardiac Valves|valve	Flaps of tissue that prevent regurgitation of blood from the ventricles to the atria or from the pulmonary arteries or aorta to the ventricles.
C23661	Mouse_Cardiac_Ventricles	Retired_Concepts	Murine Cardiac Ventricles|Cardiac Ventricles|Ventricles, Heart	The lower right and left chambers of the heart. The right pumps venous blood into the lungs and the left pumps oxygenated blood into the systemic arterial circulation.
C23662	Mouse_Humerus	Retired_Concepts	Murine Humerus|Humerus
C23663	Mouse_Hypoglossal_Nerve	Retired_Concepts	Murine Hypoglossal Nerve|Hypoglossal Nerve	The 12th cranial nerve. The hypoglossal nerve originates in the hypoglossal nucleus of the medulla and supplies motor innervation to all of the muscles of the tongue except the palatoglossus (which is supplied by the vagus). This nerve also contains proprioceptive afferents from the tongue muscles.
C23664	Mouse_Iliac_Artery	Retired_Concepts	Murine Iliac Artery|Iliac Artery	Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.
C23665	Mouse_Iliac_Vein	Retired_Concepts	Murine Iliac Vein|Iliac Vein	A vein on either side of the body which is formed by the union of the external and internal iliac veins and passes upward to join with its fellow of the opposite side to form the inferior vena cava.
C23666	Mouse_Immune_System	Retired_Concepts	Murine Immune System|Immune System|immune system	The body's defense mechanism against foreign organisms or substances and deviant native cells. It includes the humoral immune response and the cell-mediated response and consists of a complex of interrelated cellular, molecular, and genetic components.
C23667	Mouse_Intestines	Retired_Concepts	Murine Intestines|Bowel|Intestine|Intestines	The section of the alimentary canal from the STOMACH to the ANUS. It includes the LARGE INTESTINE and SMALL INTESTINE.
C23668	Mouse_Iris	Retired_Concepts	Murine Iris|Iris	The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.
C23669	Mouse_Jugular_Vein	Retired_Concepts	Murine Jugular Vein|Jugular Vein	Veins in the neck which drain the brain, face, and neck into the brachiocephalic or subclavian veins.
C23670	Mouse_Renal_Cortex	Retired_Concepts	Murine Renal Cortex|Renal Cortex	The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.
C23671	Mouse_Renal_Medulla	Retired_Concepts	Murine Renal Medulla|Renal Medulla	The internal portion of the kidney, consisting of striated conical masses, the renal pyramids, whose bases are adjacent to the cortex and whose apices form prominent papillae projecting into the lumen of the minor calyces.
C23672	Mouse_Natural_Killer_Cells	Retired_Concepts	Murine Natural Killer Cells|Killer Cells|Killer Cells, Natural|NK|NK Cell|Natural Killer Cells	Cells responsible for spontaneous cytotoxicity of a variety of tumor cells without prior immunization. These natural killer cells are found in non-immune humans and experimental animals and are thought by some to be the same as KILLER CELLS (killing by antibody-dependent cell cytotoxicity), but they can also kill in the absence of antibody.
C23673	Mouse_Lower_Extremity	Retired_Concepts	Murine Lower Extremity|Lower Extremity|Lower limb, NOS|hindlimb
C23674	Mouse_Lens	Retired_Concepts	Murine Lens|Crystalline Lens|Lens|Lens of Eye|Ocular Lens	A biconvex transparent structure of the eye through which light is focused on the retina.  The lens sits behind the iris and is supported by the zonule, which connects it to the ciliary body.  The lens is an avascular structure.
C23675	Mouse_Lumbar_Vertebrae	Retired_Concepts	Murine Lumbar Vertebrae|Lumbar Vertebrae
C23676	Mouse_Lymph_Nodes	Retired_Concepts	Murine Lymph Nodes|LYMPH NODES|Lymph Nodes|Lymph node|Lymph node proper|Lymph node, NOS|Reticuloendothelial System, Lymph Node
C23677	Mouse_Lymphatic_System	Retired_Concepts	Murine Lymphatic System|Lymphatic System|Lymphatic system|Lymphatic system (all sites)|Reticuloendothelial System, Lymphatic System
C23678	Mouse_Mast_Cells	Retired_Concepts	Murine Mast Cells|Basophilic histiocyte|Basophils, Tissue|Marrow mast cell|Mast Cells|Mastocyte	Mast cells are connective tissue cells that contain coarse, basophilic, metachromatic granules.  They are believed to contain heparin and histamine.
C23679	Mouse_Mediastinum	Retired_Concepts	Murine Mediastinum|Mediastinum
C23680	Mouse_Membrane	Retired_Concepts	Murine Membrane|Membrane|membrane
C23681	Mouse_Mesoderm	Retired_Concepts	Murine Mesoderm|Mesoderm	The middle germ layer of the embryo.
C23682	Mouse_Metacarpal_Bones	Retired_Concepts	Murine Metacarpal Bones|Metacarpal|Metacarpal Bones|Os Metacarpale
C23683	Mouse_Metatarsal_Bones	Retired_Concepts	Murine Metatarsal Bones|Metatarsal Bones	The five long bones of the METATARSUS articulating with the TARSAL BONES proximally and the TOES (phalanges) distally.
C23684	Mouse_Mitral_Valve	Retired_Concepts	Murine Mitral Valve|Mitral Valve	The valve between the left atrium and left ventricle of the heart.
C23685	Mouse_Musculoskeletal_System	Retired_Concepts	Murine Musculoskeletal System|Musculoskeletal System	The MUSCLES, bones (BONE AND BONES), and CARTILAGE of the body.
C23686	Mouse_Nervous_System	Retired_Concepts	Murine Nervous System|Nervous System|Nervous system, NOS	The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
C23687	Mouse_Nose	Retired_Concepts	Murine Nose|Nose	A specialized structure that serves as an organ of the sense of smell as well as part of the respiratory system; the term includes both the external nose and the nasal cavity.
C23688	Mouse_Occipital_Bone	Retired_Concepts	Murine Occipital Bone|Occipital Bone
C23689	Mouse_Oculomotor_Nerve	Retired_Concepts	Murine Oculomotor Nerve|Cranial Nerve III|Oculomotor Nerve|Third Cranial Nerve	The 3d cranial nerve. The oculomotor nerve sends motor fibers to the levator muscles of the eyelid and to the superior rectus, inferior rectus, and inferior oblique muscles of the eye. It also sends parasympathetic efferents (via the ciliary ganglion) to the muscles controlling pupillary constriction and accommodation. The motor fibers originate in the oculomotor nuclei of the midbrain.
C23690	Mouse_Olfactory_Nerve	Retired_Concepts	Murine Olfactory Nerve|Cranial Nerve I|First Cranial Nerve|Olfactory Nerve	The 1st cranial nerve. The olfactory nerve conveys the sense of smell. It is formed by the axons of OLFACTORY RECEPTOR NEURONS which project from the olfactory epithelium (in the nasal epithelium) to the OLFACTORY BULB.
C23691	Mouse_Optic_Disc	Retired_Concepts	Murine Optic Disc|Optic Disc|Optic Nerve Head|Optic Papilla	The portion of the optic nerve seen in the fundus with the ophthalmoscope. It is formed by the meeting of all the retinal ganglion cell axons as they enter the optic nerve.
C23692	Mouse_Optic_Nerve	Retired_Concepts	Murine Optic Nerve|Optic Nerve	The 2nd cranial nerve. The optic nerve conveys visual information from the retina to the brain. The nerve carries the axons of the retinal ganglion cells which sort at the optic chiasm and continue via the optic tracts to the brain. The largest projection is to the lateral geniculate nuclei; other important targets include the superior colliculi and the suprachiasmatic nuclei. Though known as the second cranial nerve, it is considered part of the central nervous system.
C23693	Mouse_Oropharynx	Retired_Concepts	Murine Oropharynx|Oropharynx|Oropharynx, NOS|oropharynx	Oral part of the pharynx.
C23694	Mouse_Nasal_Sinuses	Retired_Concepts	Murine Nasal Sinuses|Accessory Sinuses|Accessory sinus, NOS|Nasal And Sinuses|Nasal Sinuses|Nasal cavity/Paranasal|Nasal cavity/Paranasal sinuses|Paranasal Sinuses|Sinuses, Nasal|Sinuses, Paranasal	Air-filled extensions of the respiratory part of the nasal cavity into the frontal, ethmoid, sphenoid, and maxillary cranial bones. They vary in size and form in different individuals and are lined by the ciliated mucous membranes of the nasal cavity.
C23695	Mouse_Parasympathetic_Nervous_System	Retired_Concepts	Murine Parasympathetic Nervous System|Parasympathetic Nervous System	The craniosacral division of the autonomic nervous system. The cell bodies of the parasympathetic preganglionic fibers are in brain stem nuclei and in the sacral spinal cord. They synapse in cranial autonomic ganglia or in terminal ganglia near target organs. The parasympathetic nervous system generally acts to conserve resources and restore homeostasis, often with effects reciprocal to the sympathetic nervous system.
C23696	Mouse_Parathyroid_Gland	Retired_Concepts	Murine Parathyroid Gland|Parathyroid|Parathyroid Gland	Two small paired endocrine glands in the region of the thyroid gland. They secrete parathyroid hormone and are concerned with the metabolism of calcium and phosphorus.
C23697	Mouse_Parietal_Bone	Retired_Concepts	Murine Parietal Bone|Parietal Bone
C23698	Mouse_Pelvis	Retired_Concepts	Murine Pelvis|Pelvis|Pelvis, NOS
C23699	Mouse_Peripheral_Nerves	Retired_Concepts	Murine Peripheral Nerves|Peripheral Nerves	The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.
C23700	Mouse_Peritoneal_Cavity	Retired_Concepts	Murine Peritoneal Cavity|Peritoneal Cavity	The lower part of the abdomen that contains the intestines (the last part of the digestive tract), the stomach, and the liver. It is bound by thin membranes.
C23701	Mouse_Peritoneum	Retired_Concepts	Murine Peritoneum|Peritoneum|Peritoneum, NOS|peritoneum	Endothelial lining of the abdominal cavity, the parietal peritoneum covering the inside of the abdominal wall and the visceral peritoneum covering the bowel, the mesentery, and certain of the organs. The portion that covers the bowel becomes the serosal layer of the bowel wall.
C23702	Mouse_Peyer_s_Patches	Retired_Concepts	Murine Peyer's Patches|Peyer's Patches	Lymphoid tissue on the mucosa of the small intestine.
C23703	Mouse_Anterior_Pituitary_Gland	Retired_Concepts	Murine Anterior Pituitary Gland|Adenohypophysis|Anterior Lobe of Pituitary|Anterior Pituitary Gland|Gland, Anterior Pituitary|Glands, Anterior Pituitary|Pars Anterior Pituitary Gland|Pituitary Anterior Lobe|Pituitary Gland, Anterior	The glandular or anterior lobe of the pituitary gland which secretes several hormones.
C23704	Mouse_Posterior_Pituitary_Gland	Retired_Concepts	Murine Posterior Pituitary Gland|Neurohypophysis|Posterior Lobe of Pituitary|Posterior Pituitary Gland	The neural or post-neural lobe of the pituitary gland which stores and releases vasopressin, oxytocin, and neurophysins.
C23705	Mouse_Pulmonary_Artery	Retired_Concepts	Murine Pulmonary Artery|Pulmonary Artery	The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.
C23706	Mouse_Pulmonic_Valve	Retired_Concepts	Murine Pulmonic Valve|Pulmonary Valve|Pulmonic Valve	A valve situated at the entrance to the pulmonary trunk from the right ventricle.
C23707	Mouse_Pulmonary_Vein	Retired_Concepts	Murine Pulmonary Vein|Pulmonary Vein	The veins that return the oxygenated blood from the lungs to the left atrium of the heart.
C23708	Mouse_Radius	Retired_Concepts	Murine Radius|Radial Bone|Radius
C23709	Mouse_Renal_Artery	Retired_Concepts	Murine Renal Artery|Renal Artery	A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
C23710	Mouse_Respiratory_System	Retired_Concepts	Murine Respiratory System|Respiratory System|Respiratory system (all sites)
C23711	Mouse_Reticuloendothelial_System	Retired_Concepts	Murine Reticuloendothelial System|RE System|Reticuloendothelial System|Reticuloendothelial system, NOS
C23712	Mouse_Retroperitoneal_Space	Retired_Concepts	Murine Retroperitoneal Space|Retroperitoneal Cavity|Retroperitoneal Space	An area occupying the most posterior aspect of the abdominal cavity. It is bounded laterally by the borders of the quadratus lumborum muscles and extends from the diaphragm to the brim of the true pelvis, where it continues as the pelvic extraperitoneal space.
C23713	Mouse_Rib	Retired_Concepts	Murine Rib|Rib
C23714	Mouse_Scapula	Retired_Concepts	Murine Scapula|Scapula|Shoulder Blade
C23715	Mouse_Sclera	Retired_Concepts	Murine Sclera|Sclera|White of Eye	The white, opaque, fibrous, outer tunic of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea. It is essentially avascular but contains apertures for vessels, lymphatics, and nerves. It receives the tendons of insertion of the extraocular muscles and at the corneoscleral junction contains the canal of Schlemm. (From Cline et al., Dictionary of Visual Science, 4th ed)
C23716	Mouse_Scrotum	Retired_Concepts	Murine Scrotum|Scrotum|Scrotum, NOS
C23717	Mouse_Lunate_Bone	Retired_Concepts	Murine Lunate Bone|Lunate|Lunate Bone|Semilunar Bone	A carpal bone which is located between the scaphoid and triquelateral bones.
C23718	Mouse_Seminal_Vesicles	Retired_Concepts	Murine Seminal Vesicles|Seminal Vesicles|seminal vesicle	A saclike, glandular diverticulum on each ductus deferens in male vertebrates. It is united with the excretory duct and serves for temporary storage of semen. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
C23719	Mouse_Skeletal_System	Retired_Concepts	Murine Skeletal System|Skeletal System|Skeleton
C23720	Mouse_Skull	Retired_Concepts	Murine Skull|Cranium|Skull	The skeleton of the head including the bones of the face and the bones enclosing the brain.
C23721	Mouse_Sphenoid_Bone	Retired_Concepts	Murine Sphenoid Bone|Sphenoid Bone
C23722	Mouse_Spinal_Nerve_Roots	Retired_Concepts	Murine Spinal Nerve Roots|Spinal Nerve Roots|Spinal Roots	The paired bundles of nerve fibers entering and leaving the spinal cord at each segment. The dorsal and ventral nerve roots join to form the mixed segmental spinal nerves. The dorsal roots are generally afferent, formed by the central projections of the spinal (dorsal root) ganglia sensory cells, and the ventral roots efferent, comprising the axons of spinal motor and autonomic preganglionic neurons. There are, however, some exceptions to this afferent/efferent rule.
C23723	Mouse_Spinal_Nerves	Retired_Concepts	Murine Spinal Nerves|Spinal Nerves	The 31 paired peripheral nerves formed by the union of the dorsal and ventral spinal roots from each spinal cord segment. The spinal nerve plexuses and the spinal roots are also included.
C23724	Mouse_Sternum	Retired_Concepts	Murine Sternum|Sternum
C23725	Mouse_Subclavian_Vein	Retired_Concepts	Murine Subclavian Vein|Subclavian Vein	The continuation of the axillary vein which follows the subclavian artery and then joins the internal jugular vein to form the brachiocephalic vein.
C23726	Mouse_Sympathetic_Nervous_System	Retired_Concepts	Murine Sympathetic Nervous System|Sympathetic Nervous System	The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
C23727	Mouse_Tarsal_Bones	Retired_Concepts	Murine Tarsal Bones|Tarsal Bones	The seven bones which form the tarsus - namely, CALCANEUS, TALUS, cuboid, navicular, and first, second and third cuneiforms. The tarsus is a skeletal part of the foot.
C23728	Mouse_Temporal_Bone	Retired_Concepts	Murine Temporal Bone|Temporal Bone
C23729	Mouse_Thoracic_Vertebrae	Retired_Concepts	Murine Thoracic Vertebrae|Thoracic Vertebrae
C23730	Mouse_Thorax	Retired_Concepts	Murine Thorax|Thorax|Thorax, NOS	The upper part of the trunk between the neck and the abdomen. It contains the chief organs of the circulatory and respiratory systems. (From Stedman, 25th ed)
C23731	Mouse_Tibia	Retired_Concepts	Murine Tibia|Tibia	The second longest bone of the skeleton. It is located on the medial side of the lower leg, articulating with the FIBULA laterally, the TALUS distally, and the FEMUR proximally.
C23732	Mouse_Tissue_Types	Retired_Concepts	Murine Tissue Types|Tissue|Tissue Types	Collections of cells organized in a cooperative arrangement for the purpose of performing a particular function.
C23733	Mouse_Tonsils	Retired_Concepts	Murine Tonsils|TONSIL|Tonsil, NOS|Tonsils	A round-to-oval mass of lymphoid tissue embedded in the lateral wall of the PHARYNX situated on each side of the fauces, between the anterior and posterior pillars of the soft palate (PALATE, SOFT).
C23734	Mouse_Trabecular_Meshwork	Retired_Concepts	Murine Trabecular Meshwork|Trabecular Meshwork	A porelike structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates to the canal of Schlemm.
C23735	Mouse_Transplanted_Bone_Marrow	Retired_Concepts	Murine Transplanted Bone Marrow|Transplanted Bone Marrow
C23736	Mouse_Tricuspid_Valve	Retired_Concepts	Murine Tricuspid Valve|Tricuspid Valve	The valve consisting of three cusps situated between the right atrium and right ventricle of the heart.
C23737	Mouse_Trigeminal_Nerve	Retired_Concepts	Murine Trigeminal Nerve|Cranial Nerve V|Fifth Cranial Nerve|Nervus Trigeminus|Trigeminal Nerve	The 5th and largest cranial nerve. The trigeminal nerve is a mixed motor and sensory nerve. The larger sensory part forms the ophthalmic, mandibular, and maxillary nerves which carry afferents sensitive to external or internal stimuli from the skin, muscles, and joints of the face and mouth and from the teeth. Most of these fibers originate from cells of the trigeminal ganglion and project to the trigeminal nucleus of the brain stem. The smaller motor part arises from the brain stem trigeminal motor nucleus and innervates the muscles of mastication.
C23738	Mouse_Trigeminal_Nuclei	Retired_Concepts	Murine Trigeminal Nuclei|Trigeminal Nuclei	Nuclei of the trigeminal nerve situated in the brain stem. They include the nucleus of the spinal trigeminal tract (TRIGEMINAL NUCLEUS, SPINAL), the principal sensory nucleus, the mesencephalic nucleus, and the motor nucleus.
C23739	Mouse_Trochlear_Nerve	Retired_Concepts	Murine Trochlear Nerve|Cranial Nerve IV|Fourth Cranial Nerve|Trochlear Nerve	The 4th cranial nerve. The trochlear nerve carries the motor innervation of the superior oblique muscles of the eye.
C23740	Mouse_Ulna	Retired_Concepts	Murine Ulna|Ulna	One of the bones that comprise the forearm. The largest aspect articulates with the humerus at the elbow joint and the smallest portion of the ulna articulates with the carpal bones in the wrist. (On-line Medical Dictionary)
C23741	Mouse_Genitourinary_System	Retired_Concepts	Murine Genitourinary System|Genitourinary System|genitourinary	All the organs involved in reproduction and the formation and release of URINE. It includes the kidneys, ureters, BLADDER, URETHRA, and the organs of reproduction - ovaries, UTERUS, FALLOPIAN TUBES, VAGINA, and CLITORIS in women and the testes, SEMINAL VESICLES, PROSTATE, seminal ducts, and PENIS in men.
C23742	Mouse_Uveal_Tract	Retired_Concepts	Murine Uveal Tract|Iris, Ciliary Body and Choroid|Tunica Vasculosa of Eyeball|Uveal Tract	The pigmented vascular coat of the eyeball, consisting of the CHOROID, CILIARY BODY, and IRIS, which are continuous with each other. (Cline et al., Dictionary of Visual Science, 4th ed)
C23743	Mouse_Vagus_Nerve	Retired_Concepts	Murine Vagus Nerve|Cranial Nerve X|Pneumogastric Nerve|Tenth Cranial Nerve|Vagus Nerve	The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).
C23744	Mouse_Vas_Deferens	Retired_Concepts	Murine Vas Deferens|Vas Deferens	Duct carrying spermatozoa.
C23745	Mouse_Vein	Retired_Concepts	Murine Vein|Vein|vein	The vessels carrying blood toward the heart.
C23746	Mouse_Inferior_Vena_Cava	Retired_Concepts	Murine Inferior Vena Cava|Inferior Vena Cava	The venous trunk which receives blood from the lower extremities and from the pelvic and abdominal organs.
C23747	Mouse_Superior_Vena_Cava	Retired_Concepts	Murine Superior Vena Cava|Superior Vena Cava	The venous trunk which returns blood from the head, neck, upper extremities and chest.
C23748	Mouse_Vena_Cava	Retired_Concepts	Murine Vena Cava|Vena Cava	The inferior and superior venae cavae.
C23749	Mouse_Venule	Retired_Concepts	Murine Venule|Venule	The minute vessels that collect blood from the capillary plexuses and join together to form veins.
C23750	Mouse_Vertebral_Artery	Retired_Concepts	Murine Vertebral Artery|Vertebral Artery	The first branch of the subclavian artery with distribution to muscles of the neck, vertebrae, spinal cord, cerebellum and interior of the cerebrum.
C23751	Mouse_Vestibular_Nerve	Retired_Concepts	Murine Vestibular Nerve|Vestibular Nerve|Vestibular Nerve (VIII)|Vestibular Root of Eighth Cranial Nerve	The vestibular part of the 8th cranial nerve (VESTIBULOCOCHLEAR NERVE). The vestibular nerve fibers arise from neurons of Scarpa's ganglion and project peripherally to vestibular hair cells and centrally to the VESTIBULAR NUCLEI of the BRAIN STEM. These fibers mediate the sense of balance and head position.
C23752	Mouse_Vestibular_Nuclei	Retired_Concepts	Murine Vestibular Nuclei|Vestibular Nuclei	The four cellular masses in the floor of the fourth ventricle giving rise to a widely dispersed special sensory system. Included is the superior, medial, inferior, and LATERAL VESTIBULAR NUCLEUS. (From Dorland, 27th ed)
C23753	Mouse_Vocal_Cords	Retired_Concepts	Murine Vocal Cords|Vocal Cords	The folds of mucous membrane along either wall of the larynx from the angle between the laminae of the thyroid cartilage to the vocal process of the arytenoid cartilage.
C23754	Mouse_Corneal_Limbus	Retired_Concepts	Murine Corneal Limbus|Corneal Limbus	An annular transitional zone, approximately 1 mm wide, between the cornea and the bulbar conjunctiva and sclera. It is highly vascular and is involved in the metabolism of the cornea. It is ophthalmologically significant in that it appears on the outer surface of the eyeball as a slight furrow, marking the line between the clear cornea and the sclera. (Dictionary of Visual Science, 3d ed)
C23755	Mouse_Tibial_Arteries	Retired_Concepts	Murine Tibial Arteries|Tibial Arteries	The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and foot. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot.
C23756	Mouse_Anterior_Tibial_Artery	Retired_Concepts	Murine Anterior Tibial Artery|Anterior Tibial Artery
C23757	Mouse_Posterior_Tibial_Artery	Retired_Concepts	Murine Posterior Tibial Artery|Posterior Tibial Artery	The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior.
C23758	Mouse_Third_Ventricle_of_Brain	Retired_Concepts	Murine Third Ventricle of Brain|Third Cerebral Ventricle|Third Ventricle|Third Ventricle of Brain|Ventricle, Third	A centrally placed component of the ventricular system of the brain located in the diencephalon.  Cerebrospinal fluid from the lateral ventricles flows into the third ventricle via the foramina of Monroe and exits the third ventricle via the aqueduct of Sylvius.  The thalamus and hypothalamus border the lateral walls of the third ventricle.
C23759	Mouse_Fourth_Ventricle_of_Brain	Retired_Concepts	Murine Fourth Ventricle of Brain|Fourth Ventricle|Fourth Ventricle of Brain	An irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the CEREBRAL AQUEDUCT above, and through its lateral and median apertures it communicates with the subarachnoid space.
C23760	Mouse_Anterior_Cerebral_Arteries	Retired_Concepts	Murine Anterior Cerebral Arteries|Anterior Cerebral Arteries	Artery formed by the bifurcation of the internal carotid artery (CAROTID ARTERY, INTERNAL). Branches of the anterior cerebral artery supply the CAUDATE NUCLEUS, INTERNAL CAPSULE, PUTAMEN, SEPTAL NUCLEI, GYRUS CINGULI, and surfaces of the FRONTAL LOBE and PARIETAL LOBE.
C23761	Mouse_Middle_Cerebral_Arteries	Retired_Concepts	Murine Middle Cerebral Arteries|Middle Cerebral Arteries	The largest and most complex of the cerebral arteries. Branches of the middle cerebral artery supply the insular region, motor and premotor areas, and large regions of the association cortex.
C23762	Mouse_Posterior_Cerebral_Arteries	Retired_Concepts	Murine Posterior Cerebral Arteries|Posterior Cerebral Arteries	Artery formed by the bifurcation of the BASILAR ARTERY. Branches of the posterior cerebral artery supply portions of the OCCIPITAL LOBE, PARIETAL LOBE, inferior temporal gyrus, brainstem, and CHOROID PLEXUS.
C23763	Mouse_Conus_Medullaris	Retired_Concepts	Murine Conus Medullaris|Conus Medullaris
C23764	Mouse_Anterior_Spinal_Artery	Retired_Concepts	Murine Anterior Spinal Artery|Anterior Spinal Artery
C23765	Mouse_Lateral_Ventricle_of_Brain	Retired_Concepts	Murine Lateral Ventricle of Brain|Lateral Ventricle|Lateral Ventricle of Brain|Lateral Ventricles|Ventricle, Lateral|Ventricles, Lateral	Cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the SEPTUM PELLUCIDUM, and each communicates with the THIRD VENTRICLE by the foramen of Monro, through which also the choroid plexuses (CHOROID PLEXUS) of the lateral ventricles become continuous with that of the third ventricle.
C23766	Mouse_Nucleus_Ambiguus	Retired_Concepts	Murine Nucleus Ambiguus|Nucleus Ambiguus
C23767	Mouse_Abducens_Nucleus	Retired_Concepts	Murine Abducens Nucleus|Abducens Nucleus|Sixth Cranial Nerve Nucleus
C23768	Mouse_Cochlear_Nuclei	Retired_Concepts	Murine Cochlear Nuclei|Cochlear Nuclei	The brain stem nucleus that receives the central input from the cochlear nerve. The cochlear nucleus is located lateral and dorsolateral to the inferior cerebellar peduncles and is functionally divided into dorsal and ventral parts. It is tonotopically organized, performs the first stage of central auditory processing, and projects (directly or indirectly) to higher auditory areas including the superior olivary nuclei, the medial geniculi, the inferior colliculi, and the auditory cortex.
C23769	Mouse_Radial_Artery	Retired_Concepts	Murine Radial Artery|Radial Artery	The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.
C23770	Mouse_Ulnar_Artery	Retired_Concepts	Murine Ulnar Artery|Ulnar Artery	The larger of the two terminal branches of the brachial artery, beginning about one centimeter distal to the bend of the elbow. Like the RADIAL ARTERY, its branches may be divided into three groups corresponding to their locations in the forearm, wrist, and hand.
C23771	Mouse_Pleural_Cavity	Retired_Concepts	Murine Pleural Cavity|Pleural Cavity
C23772	Mouse_Skin_Graft	Retired_Concepts	Murine Skin Graft|Skin Graft|skin graft	Grafts used in the treatment of skin loss, usually caused by burn injuries.
C23773	Mouse_Coronary_Artery	Retired_Concepts	Murine Coronary Artery|Coronary Artery
C23774	Mouse_Cervical_Neck_Region	Retired_Concepts	Murine Cervical Neck Region|Cervical|Cervical Neck Region
C23775	Mouse_Lumbar_Plexus	Retired_Concepts	Murine Lumbar Plexus|Lumbar Plexus
C23776	Mouse_Sacral_Plexus	Retired_Concepts	Murine Sacral Plexus|Sacral Plexus
C23777	Mouse_Reactive_Lymphocyte	Retired_Concepts	Murine Reactive Lymphocyte|Atypical lymphocyte|Reactive Lymphocyte
C23778	Mouse_Squamous_Epithelium	Retired_Concepts	Murine Squamous Epithelium|Squamous Epithelium	An epithelium in which the cells are flattened. May be simple (e.g. Endothelium) or stratified (e.g. Epidermis). (On-line Medical Dictionary)
C23779	Mouse_Squamous_Cells	Retired_Concepts	Murine Squamous Cells|Squamous Cells|squamous cells
C23780	Mouse_Stratum_Spinosum	Retired_Concepts	Murine Stratum Spinosum|Stratum Spinosum	The part of the epidermis layer of the skin containing Langerhans cells, which are dendritic, MHC class II-expressing antigen presenting cells.
C23781	Mouse_Breast_Female	Retired_Concepts	Murine Breast, Female|Breast, Female	breast. 1. The pectoral surface of the thorax. 2. The organ of milk secretion; one of two hemispheric projections of variable size situated in the subcutaneous layer over the pectoralis major muscle on either side of the chest of the mature female; it is rudimentary in the male.
C23782	Mouse_Vertebral_Body	Retired_Concepts	Murine Vertebral Body|Vertebral Body
C23783	Mouse_Sacral_Vertebrae	Retired_Concepts	Murine Sacral Vertebrae|Sacral Vertebrae
C23784	Mouse_Scaphoid_Bone	Retired_Concepts	Murine Scaphoid Bone|Navicular Bone of Hand|Os Scaphoideum|Scaphoid|Scaphoid Bone	The bone which is located most lateral in the proximal row of CARPAL BONES.
C23785	Mouse_Pisiform_Bone	Retired_Concepts	Murine Pisiform Bone|Pisiform|Pisiform Bone|Pisiform Bone of Hand
C23786	Mouse_Capitate_Bone	Retired_Concepts	Murine Capitate Bone|Capitate|Capitate Bone
C23787	Mouse_Trapezial_Bone	Retired_Concepts	Murine Trapezial Bone|Greater Multiangular Bone|Trapezial Bone|Trapezium
C23788	Mouse_Triangular_Bone	Retired_Concepts	Murine Triangular Bone|Triangular Bone
C23789	Mouse_Trapezoid_Bone	Retired_Concepts	Murine Trapezoid Bone|Lesser Multiangular Bone|Trapezoid|Trapezoid Bone
C23790	Mouse_Hamate_Bone	Retired_Concepts	Murine Hamate Bone|Hamate|Hamate Bone|Unciform bone|Uncinate bone
C23791	Mouse_Phalanges_of_Hand	Retired_Concepts	Murine Phalanges of Hand|Bone of Finger|Phalanges of Hand|Phalanx of Finger|Phalanx of Hand
C23792	Mouse_Proximal_Phalanx_of_Hand	Retired_Concepts	Murine Proximal Phalanx of Hand|Proximal Phalanx of Finger|Proximal Phalanx of Hand
C23793	Mouse_Middle_Phalanx_of_Hand	Retired_Concepts	Murine Middle Phalanx of Hand|Middle Phalanx of Finger|Middle Phalanx of Hand
C23794	Mouse_Distal_Phalanx_of_Hand	Retired_Concepts	Murine Distal Phalanx of Hand|Distal Phalanx of Finger|Distal Phalanx of Hand
C23795	Mouse_Endothelial_Cells	Retired_Concepts	Murine Endothelial Cells|Endothelial Cells	One of the squamous cells forming the lining of blood and lymph vessels and the inner layer of the endocardium. SYN endotheliocyte.
C23796	Mouse_Transitional_Cells	Retired_Concepts	Murine Transitional Cells|Transitional Cells|transitional cells
C23797	Mouse_Alveolar_Epithelium	Retired_Concepts	Murine Alveolar Epithelium|Alveolar Epithelium|Lung Alveolar Epithelia
C23798	Mouse_Right_Atrium	Retired_Concepts	Murine Right Atrium|Right Atrium
C23799	Mouse_Left_Atrium	Retired_Concepts	Murine Left Atrium|Left Atrium|Left Atrium of Heart
C23800	Mouse_Right_Ventricle	Retired_Concepts	Murine Right Ventricle|Right Ventricle
C23801	Mouse_Left_Ventricle	Retired_Concepts	Murine Left Ventricle|Left Ventricle
C23802	Mouse_Left_Coronary_Artery	Retired_Concepts	Murine Left Coronary Artery|Left Coronary Artery
C23803	Mouse_Diagonal_Branch_of_Descending_Branch_of_Left_Coronary_Artery	Retired_Concepts	Murine Diagonal Branch of Descending Branch of Left Coronary Artery|Diagonal Branch of Descending Branch of Left Coronary Artery
C23804	Mouse_Circumflex_Branch_of_Left_Coronary_Artery	Retired_Concepts	Murine Circumflex Branch of Left Coronary Artery|Circumflex Branch of Left Coronary Artery
C23805	Mouse_RIght_Coronary_Artery	Retired_Concepts	Murine RIght Coronary Artery|RIght Coronary Artery
C23806	Mouse_Posterior_Spinal_Artery	Retired_Concepts	Murine Posterior Spinal Artery|Posterior Spinal Artery
C23807	Mouse_Venous_Sinus	Retired_Concepts	Murine Venous Sinus|Venous Sinus
C23808	Mouse_Cardiac_Vein	Retired_Concepts	Murine Cardiac Vein|Cardiac Vein
C23809	Mouse_Great_Cardiac_Vein	Retired_Concepts	Murine Great Cardiac Vein|Great Cardiac Vein
C23810	Mouse_Middle_Cardiac_Vein	Retired_Concepts	Murine Middle Cardiac Vein|Middle Cardiac Vein
C23811	Mouse_Small_Cardiac_Vein	Retired_Concepts	Murine Small Cardiac Vein|Small Cardiac Vein
C23812	Mouse_Coronary_Vein	Retired_Concepts	Murine Coronary Vein|Coronary Vein
C23813	Mouse_Brachial_Vein	Retired_Concepts	Murine Brachial Vein|Brachial Vein
C23814	Mouse_Urothelium	Retired_Concepts	Murine Urothelium|Urothelium	The epithelial lining of the URINARY TRACT.
C23815	Mouse_Renal_Capsule	Retired_Concepts	Murine Renal Capsule|Renal Capsule|renal capsule
C23816	Mouse_Renal_Pyramid	Retired_Concepts	Murine Renal Pyramid|Renal Pyramid
C23817	Mouse_Renal_Pelvis	Retired_Concepts	Murine Renal Pelvis|Kidney/Renal Pelvis|Renal Pelvis	The flattened, funnel-shaped expansion connecting the URETER to the KIDNEY CALICES.
C23818	Mouse_Visual_System	Retired_Concepts	Murine Visual System|Visual Pathway|Visual System
C23819	Mouse_Auditory_System	Retired_Concepts	Murine Auditory System|Auditory System	The organs involved with detecting and processing auditory information, including the pinna, external auditory canal, ear drum, middle ear, and inner ear (including the cochlear organ).
C23820	Mouse_Cerebral_Falx	Retired_Concepts	Murine Cerebral Falx|Cerebral Falx|Falx Cerebri|Falx of Cerebrum
C23821	Mouse_Central_Canal_of_Spinal_Cord	Retired_Concepts	Murine Central Canal of Spinal Cord|Central Canal|Central Canal of Spinal Cord
C23822	Mouse_Cervical_Spinal_Cord	Retired_Concepts	Murine Cervical Spinal Cord|Cervical Portion of Spinal Cord|Cervical Spinal Cord
C23823	Mouse_Cervical_Spinal_Nerve_Roots	Retired_Concepts	Murine Cervical Spinal Nerve Roots|Cervical Spinal Nerve Roots
C23824	Mouse_Thoracic_Spinal_Cord	Retired_Concepts	Murine Thoracic Spinal Cord|Thoracic Portion of Spinal Cord|Thoracic Spinal Cord
C23825	Mouse_Lumbar_Spinal_Cord	Retired_Concepts	Murine Lumbar Spinal Cord|Lumbar Portion of Spinal Cord|Lumbar Spinal Cord
C23826	Mouse_Sacral_Spinal_Cord	Retired_Concepts	Murine Sacral Spinal Cord|Sacral Spinal Cord
C23827	Mouse_Oculomotor_Nucleus	Retired_Concepts	Murine Oculomotor Nucleus|Oculomotor Nucleus
C23828	Mouse_Facial_Nerve_Nucleus	Retired_Concepts	Murine Facial Nerve Nucleus|Facial Nerve Nucleus|Facial Nucleus
C23829	Mouse_Hypoglossal_Nucleus	Retired_Concepts	Murine Hypoglossal Nucleus|Hypoglossal Nucleus
C23830	Mouse_Posterior_Chamber_of_Eye	Retired_Concepts	Murine Posterior Chamber of Eye|Posterior Chamber (Eye)|Posterior Chamber of Eye
C23831	Mouse_Palpebral_Conjunctiva	Retired_Concepts	Murine Palpebral Conjunctiva|Palpebral Conjunctiva	The part of the conjunctiva, a thin transparent mucous membrane, that covers the posterior surface of the eyelids.
C23832	Mouse_Bulbar_Conjunctiva	Retired_Concepts	Murine Bulbar Conjunctiva|Bulbar Conjunctiva|Ocular Conjunctiva	The part of the conjunctiva, a thin transparent mucous membrane, that is loosely attached the orbital septum and covers the anterior surface of the sclera.
C23833	Mouse_Supraclavicular_Lymph_Nodes	Retired_Concepts	Murine Supraclavicular Lymph Nodes|Supraclavicular Lymph Nodes|supraclavicular lymph nodes
C23834	Mouse_Axillary_Lymph_Node	Retired_Concepts	Murine Axillary Lymph Node|Axillary Lymph Node|axillary lymph nodes
C23835	Mouse_Thoracic_Cavity	Retired_Concepts	Murine Thoracic Cavity|Thoracic Cavity
C23836	Mouse_Posterior_Eye_Segment	Retired_Concepts	Murine Posterior Eye Segment|Posterior Eye Segment
C23837	Mouse_Integumentary_System	Retired_Concepts	Murine Integumentary System|Dermatologic Body System|Integumentary System
C23838	Mouse_Other_unique_Body_System	Retired_Concepts	Murine Other/unique Body System|Other/unique Body System
C23839	Mouse_Hematopoietic_Body_System	Retired_Concepts	Murine Hematopoietic Body System|Hematopoietic Body System|Hematopoietic system, NOS
C23840	Mouse_Mucosa-Associated_Lymphoid_Tissue	Retired_Concepts	Murine Mucosa-Associated Lymphoid Tissue|Mucosa-Associated Lymphoid Tissue
C23841	Mouse_Spinal_Accessory_Nerve	Retired_Concepts	Murine Spinal Accessory Nerve|Spinal Accessory Nerve
C23842	Mouse_Caco-2_Cells	Retired_Concepts	Murine Caco-2 Cells|Caco-2 Cells	Human colonic adenocarcinoma cells that are able to express differentiation features characteristic of mature intestinal cells, such as enterocytes or mucus cells. These cells are valuable in vitro tools for studies related to intestinal cell function and differentiation.
C23843	Mouse_Abnormal_Cells	Retired_Concepts	Murine Abnormal Cells|Abnormal Cells|Abnormal cell
C23844	Mouse_Atypical_Lymphoblast	Retired_Concepts	Murine Atypical Lymphoblast|Atypical Lymphoblast
C23845	Mouse_Small_Cleaved_Cell	Retired_Concepts	Murine Small Cleaved Cell|Small Cleaved Cell	A lymphoid cell of follicular center cell origin that has an irregularly shaped nucleus with clumped chromatin, absent nucleoli, and one or more clefts in the nuclear membrane.
C23846	Mouse_Micromegakaryocyte	Retired_Concepts	Murine Micromegakaryocyte|Atypically small megakaryocyte|Micromegakaryocyte
C23847	Mouse_Cancer_Cell	Retired_Concepts	Murine Cancer Cell|Cancer Cell	Cells of, or derived from, a malignant tumor.
C23848	Mouse_Blast_Cells	Retired_Concepts	Murine Blast Cells|Blast Cells|Blasts	Blast cells are in an immature (undifferentiated) stage in cellular development, occurring before the appearance of the definitive characteristics exhibited by fully differentiated cells.
C23849	Mouse_Organ_System	Retired_Concepts	Murine Organ System|Body Systems|Organ System	is an anatomical structure that consists of all members of one or more organ subclass; these members are interconnected by anatomical structures or body substances. (UWDA97)
C23850	Mouse_EBV-specific_Cytotoxic_T-lymphocytes	Retired_Concepts	Murine EBV-specific Cytotoxic T-lymphocytes|EBV-specific Cytotoxic T-lymphocytes
C23851	Mouse_Large_Granular_Lymphocytes	Retired_Concepts	Murine Large Granular Lymphocytes|LGL|Large Granular Lymphocytes
C23852	Mouse_Tumor_Cells	Retired_Concepts	Murine Tumor Cells|Tumor Cells	Cells of, or derived from, a tumor.
C23853	Mouse_Supratentorial	Retired_Concepts	Murine Supratentorial|Supratentorial|supratentorial
C23854	Mouse_Lumbar_Spinal_Nerve_Roots	Retired_Concepts	Murine Lumbar Spinal Nerve Roots|Lumbar Spinal Nerve Roots
C23855	Mouse_Sacral_Spinal_Nerve_Roots	Retired_Concepts	Murine Sacral Spinal Nerve Roots|Sacral Spinal Nerve Roots
C23856	Mouse_Thoracic_Spinal_Nerve_Roots	Retired_Concepts	Murine Thoracic Spinal Nerve Roots|Thoracic Spinal Nerve Roots
C23857	Mouse_Renal_Calyces	Retired_Concepts	Murine Renal Calyces|Renal Calyces
C23858	Mouse_Corneal_Epithelium	Retired_Concepts	Murine Corneal Epithelium|Corneal Epithelium	Stratified squamous epithelium that covers the outer surface of the CORNEA. It is smooth and contains many free nerve endings.
C23859	Mouse_Nerve_Plexi	Retired_Concepts	Murine Nerve Plexi|Nerve Plexi	is a subdivision of the peripheral nervous system (organ system subdivision), which consists of subdivisions of two or more nerves, which are interconnected with one another to form an network through which nerve fibers of the constituent nerves of the plexus become regrouped; together with other nerve plexuses and nerves, it constitutes the peripheral nervous system. Example(s): brachial plexus, cardiac plexus, inferior hypogastric plexus.
C23860	Mouse_Intrapulmonary_Bronchus	Retired_Concepts	Murine Intrapulmonary Bronchus|Intrapulmonary Bronchus
C23861	Mouse_Meningeal	Retired_Concepts	Murine Meningeal|Meningeal
C23862	Mouse_Xenograft	Retired_Concepts	Murine Xenograft|Xenograft
C23863	Mouse_Vertebrae	Retired_Concepts	Murine Vertebrae|Vertebrae
C23864	Mouse_Dorsal_Motor_Nucleus_of_the_Vagus	Retired_Concepts	Murine Dorsal Motor Nucleus of the Vagus|DMN|Dorsal Motor Nucleus of the Vagus
C23865	Mouse_Embryonic_Stem_Cells	Retired_Concepts	Murine Embryonic Stem Cells|Embryonic Stem Cells|Pluripotent Stem Cell	Embryonic stem cells are pluripotent and can give rise to all of the different types of specialized cells in the body but are incapable of forming an entire organism under any known condition.
C23866	Mouse_Gut_Associated_Lymphoid_Tissue	Retired_Concepts	Murine Gut Associated Lymphoid Tissue|GALT|Gut Associated Lymphoid Tissue	Non-encapsulated accumulations of lymphoid tissue in the alimentary tract that form a secretory immune system containing cells committed to IgA or IgE synthesis; include tonsils, Peyer's patches, lamina propria, and appendix. (CSP98)
C23867	Mouse_Mammary_Epithelium	Retired_Concepts	Murine Mammary Epithelium|Mammary Epithelium
C23868	Mouse_Peripheral_Blood_Lymphocyte	Retired_Concepts	Murine Peripheral Blood Lymphocyte|PBL|Peripheral Blood Lymphocyte
C23869	Mouse_Autologous_Lymphocytes	Retired_Concepts	Murine Autologous Lymphocytes|Autologous Lymphocytes
C23870	Mouse_Autologous_Tumor_Cells	Retired_Concepts	Murine Autologous Tumor Cells|Autologous Tumor Cells|autologous tumor cells
C23871	Mouse_Coactivated_T_Cells	Retired_Concepts	Murine Coactivated T Cells|Coactivated T Cells
C23872	Mouse_Intracarotid	Retired_Concepts	Murine Intracarotid|Intracarotid
C23873	Mouse_Intrathecal	Retired_Concepts	Murine Intrathecal|Intrathecal
C23874	Mouse_Medial_Supraclavicular_Lymph_Nodes	Retired_Concepts	Murine Medial Supraclavicular Lymph Nodes|Medial Supraclavicular Lymph Nodes|medial supraclavicular lymph nodes
C23875	Mouse_Neurosecretory_System	Retired_Concepts	Murine Neurosecretory System|Neuroendocrine System|Neurosecretory System|neuroendocrine
C23876	Mouse_Peripheral_Blood_Stem_Cells	Retired_Concepts	Murine Peripheral Blood Stem Cells|PBSC|Peripheral Blood Stem Cells|peripheral stem cells
C23877	Mouse_Sentinel_Lymph_Node	Retired_Concepts	Murine Sentinel Lymph Node|Sentinel Lymph Node|sentinel lymph node
C23878	Mouse_Ductal_Epithelium	Retired_Concepts	Murine Ductal Epithelium|Duct|Ductal Epithelium
C23879	Mouse_Somatic_Cells	Retired_Concepts	Murine Somatic Cells|Somatic Cells|somatic cells
C23880	Mouse_Embryonic_Tissue	Retired_Concepts	Murine Embryonic Tissue|Embryonic Tissue
C23881	Mouse_Splenocytes	Retired_Concepts	Murine Splenocytes|Splenocytes	Cells of the spleen.
C23882	Mouse_Upper_Aerodigestive_Passage	Retired_Concepts	Murine Upper Aerodigestive Passage|Upper Aerodigestive|Upper Aerodigestive Passage
C23883	Mouse_Nervous_System_Fluids_and_Secretions	Retired_Concepts	Murine Nervous System Fluids and Secretions|Nervous System Fluids and Secretions|Nervous System Fluids, Secretion|Nervous System, Fluids, Secretions
C23884	Mouse_Peripheral_Blood_Mononuclear_Cell	Retired_Concepts	Murine Peripheral Blood Mononuclear Cell|PBMC|Peripheral Blood Mononuclear Cell
C23885	Mouse_Nervous_System_Ear	Retired_Concepts	Murine Nervous System, Ear|Nervous System, Ear
C23886	Mouse_Neuro-Ocular_System	Retired_Concepts	Murine Neuro-Ocular System|Nervous System, Eye|Neuro-Ocular System	The components of the eye that are also part of the nervous system, including the retina and optic nerve.
C23887	Mouse_Exocrine_System	Retired_Concepts	Murine Exocrine System|Exocrine System	exocrine gland. a gland from which secretions reach a free surface of the body by ducts.
C23888	Mouse_Mammalian_Cell	Retired_Concepts	Murine Mammalian Cell|Mammalian Cell	A cell originating from or isolated from an animal of class Mammalia.
C23889	Mouse_Breast_Cancer_Cells	Retired_Concepts	Murine Breast Cancer Cells|Breast Cancer Cells
C23890	Mouse_Liver_Stem_Cells	Retired_Concepts	Murine Liver Stem Cells|Liver Stem Cells
C23891	Mouse_Trachea_and_Bronchus	Retired_Concepts	Murine Trachea and Bronchus|RESPIRATORY SYSTEM, TRACHEA, BRONCHUS|TRACHEA, BRONCHUS|Trachea and Bronchus	Trachea -The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi. Bronchi-The larger air passages of the lungs arising from the terminal bifurcation of the trachea. (from MSH98)
C23892	Mouse_Clonogen	Retired_Concepts	Murine Clonogen|Clonogen	A tumor progenitor cell.
C23893	Mouse_Gut_Epithelium	Retired_Concepts	Murine Gut Epithelium|Gut Epithelium	The epithelium which lines the intestinal tract.
C23894	Mouse_Connective_And_Soft_Tissue	Retired_Concepts	Murine Connective And Soft Tissue|Connective And Soft Tissue
C23895	Mouse_Genital_System_Female_Other	Retired_Concepts	Murine Genital System Female Other|Genital System Female Other|Other Genital Female	Relating to the vagina, to any sheath, or other female genitalia.
C23896	Mouse_Genital_System_Male_Other	Retired_Concepts	Murine Genital System Male Other|Genital System Male Other
C23897	Mouse_Ascending_Spinal_Cord_Tracts	Retired_Concepts	Murine Ascending Spinal Cord Tracts|Ascending Spinal Cord Tracts|Ascending Spinal Tracts|Ascending Tracts of Spinal Cord
C23898	Mouse_Tumor-Associated_Vasculature	Retired_Concepts	Murine Tumor-Associated Vasculature|Tumor-Associated Vasculature	New blood vessels formed by solid tumors.
C23899	Mouse_Descending_Spinal_Cord_Tracts	Retired_Concepts	Murine Descending Spinal Cord Tracts|Descending Spinal Cord Tracts|Descending Spinal Tracts
C23900	Mouse_Pontine_Base	Retired_Concepts	Murine Pontine Base|Base of Pons|Basis Pontis|Pontine Base
C23901	Mouse_Breast	Retired_Concepts	Murine Breast|Breast|Breast, NOS
C23902	Mouse_Peripheral_Nerve_Sheath	Retired_Concepts	Murine Peripheral Nerve Sheath|Peripheral Nerve Sheath
C23903	Mouse_Cervicomedullary_Junction	Retired_Concepts	Murine Cervicomedullary Junction|Cervicomedullary Junction
C23904	Mouse_Supratentorial_Nervous_System	Retired_Concepts	Murine Supratentorial Nervous System|Supratentorial Anatomy|Supratentorial Nervous System
C23905	Mouse_Infratentorial_Nervous_System	Retired_Concepts	Murine Infratentorial Nervous System|Infratentorial Anatomy|Infratentorial Nervous System
C23906	Mouse_Premalignant_Cells	Retired_Concepts	Murine Premalignant Cells|Premalignant Cells|precancerous cells|premalignant	Cells which show sign/s, that they can become cancerous.
C23907	Mouse_Pluripotent_Stem_Cell	Retired_Concepts	Murine Pluripotent Stem Cell|Embryonic Stem Cell|Pluripotent Stem Cell
C23908	Mouse_Totipotent_Stem_Cell	Retired_Concepts	Murine Totipotent Stem Cell|Totipotent Stem Cell	Totipotent stem cells, such as the product of fertilization of an ovum and its progeny, are stem cells that have total potency to form an entire mature organism, e.g., a human being, although only if placed in a woman's uterus.
C23909	Mouse_Atypical_Mononuclear_Cell	Retired_Concepts	Murine Atypical Mononuclear Cell|Atypical Mononuclear Cell
C23910	Mouse_Intracranial_Arteries	Retired_Concepts	Murine Intracranial Arteries|Intracranial Arteries	Arteries which have their origins within the intracranial cavity.
C23911	Mouse_Graft	Retired_Concepts	Murine Graft|Graft|graft
C23912	Mouse_Bones_of_Lower_Extremity	Retired_Concepts	Murine Bones of Lower Extremity|Bones of Lower Extremity
C23913	Mouse_Bones_of_Upper_Extremity	Retired_Concepts	Murine Bones of Upper Extremity|Bones of Upper Extremity	The bones of the upper and lower ARM. They include the CLAVICLE and SCAPULA.
C23914	Mouse_Interval_Lymph_Node	Retired_Concepts	Murine Interval Lymph Node|Interval Lymph Node|interval lymph node	nodes that lie along the course of a lymphatic vessel between a primary melanoma site and a recognized node field. (from Medscape)
C23915	Mouse_Neural_Stem_Cells	Retired_Concepts	Murine Neural Stem Cells|Neural Stem Cells
C23916	Mouse_Alveoli	Retired_Concepts	Murine Alveoli|Alveoli
C23917	Mouse_Caruncle	Retired_Concepts	Murine Caruncle|Caruncle	A small epidermoid structure of the conjunctiva of the eye that lies near the inner canthus.  It serves as a transition zone between cutaneous and mucous membrane components.
C23918	Mouse_Cybrid	Retired_Concepts	Murine Cybrid|Cybrid	A hybrid cell with cytoplasm (or cytoplasmic components) of one cell inserted into another cell.
C23919	Mouse_Episclera	Retired_Concepts	Murine Episclera|Episclera	A thin fibrous membrane that covers the outer surface of the anteriors sclera and contains blood vessels which supply the sclera.
C23920	Mouse_Lobule	Retired_Concepts	Murine Lobule|Lobule
C23921	Mouse_Neuroblast	Retired_Concepts	Murine Neuroblast|Neuroblast	An embryonic nerve cell capable of differentiating into a neuron.
C23922	Mouse_Red_Pulp	Retired_Concepts	Murine Red Pulp|Red Pulp	Splenic pulp seen grossly as a reddish brown substance, due to its abundance of red blood cells, consisting of splenic sinuses and the tissue intervening between them (splenic cords).
C23923	Mouse_White_Pulp	Retired_Concepts	Murine White Pulp|White Pulp	The part of the spleen that consists of nodules and other lymphatic concentrations.
C23924	Mouse_Thymocyte	Retired_Concepts	Murine Thymocyte|Thymocyte	A cell that develops in the thymus, seemingly from a stem cell of bone marrow and of fetal liver, and is the precursor of the thymus-derived lymphocyte (T lymphocyte) that effects cell-mediated (delayed type) sensitivity.
C23925	Mouse_Spinal_Cord_Tracts	Retired_Concepts	Murine Spinal Cord Tracts|Ascending and Descending Tracts of Spinal Cord|Spinal Cord Tracts|Tracts of Spinal Cord
C23926	Mouse_Vestibulocochlear_Nerve	Retired_Concepts	Murine Vestibulocochlear Nerve|Cranial Nerve Eight|Cranial Nerve VIII|Eighth Cranial Nerve|VIIIth Cranial Nerve|Vestibulocochlear Nerve	The eighth cranial nerve composed of the acoustic nerve and the vestibular nerve.  The nerve travels from the inner ear, enters the cranial cavity through the internal auditory foramen and joins the brainstem.  The auditory nerve conveys impulses from the cochlea of the inner ear to the auditory nuclei of the brainstem.  The vestibular nerve carries information from the labyrinths of the inner ear to the vestibular nuclei of the brainstem.
C23927	Mouse_Body_Space	Retired_Concepts	Murine Body Space|Body Space	is a three-dimensional anatomical spatial entity, which is generated by morphogenetic or other physiologic processes that generate anatomical structures; it is enclosed by anatomical structures and contains one or more anatomical structures or body substances. Example(s): celom, thoracic cavity, lesser sac of peritoneum, cavity of right atrium, lumen of blood vessel, mediastinum, anterior compartment of forearm, intervertebral foramen.
C23928	Mouse_Spine	Retired_Concepts	Murine Spine|Spinal Column|Spine|Vertebral Column	The spinal or vertebral column.
C23929	Mouse_Major_Salivary_Gland_NOS	Retired_Concepts	Murine Major Salivary Gland, NOS|Major Salivary Gland, NOS
C23930	Mouse_Rhabdomyocytes	Retired_Concepts	Murine Rhabdomyocytes|Muscle Fibers|Rhabdomyocytes|Skeletal Muscle Cell	Large single cells, either cylindrical or prismatic in shape, that form the basic unit of muscle tissue. They consist of a soft contractile substance enclosed in a tubular sheath.
C23931	Mouse_Leiomyocyte	Retired_Concepts	Murine Leiomyocyte|Leiomyocyte|Smooth Muscle Cell
C23932	Mouse_Cardiocyte	Retired_Concepts	Murine Cardiocyte|Cardiocyte|Heart Muscle Cell
C23933	Mouse_Ependymocyte	Retired_Concepts	Murine Ependymocyte|Ependymocyte
C23934	Mouse_Endocardium	Retired_Concepts	Murine Endocardium|Endocardium	The innermost layer of the heart, comprised of endothelial cells.
C23935	Mouse_Pericardium	Retired_Concepts	Murine Pericardium|Pericardium	The fibroserous sac surrounding the heart and the roots of the great vessels.
C23936	Mouse_Epithelial_Cells_Specialized	Retired_Concepts	Murine Epithelial Cells, Specialized|Epithelial Cells, Specialized
C23937	Mouse_Gross_Anatomy_Concepts	Retired_Concepts	Murine Gross Anatomy Concepts|Gross Anatomy Concepts
C23938	Mouse_Lymphokine_Activated_Killer_Cells	Retired_Concepts	Murine Lymphokine Activated Killer Cells|Cell, LAK|Cells, LAK|Killer Cells, Lymphokine-Activated|LAK|LAK cell|LAK cells|Lak - Lymphokine Activated Killer Cells|Lymphokine Activated Killer Cells|lymphokine activated killer cells|lymphokine-activated killer cells	Cytolytic lymphocytes with the unique capacity of killing natural killer (NK)-resistant fresh tumor cells. They are interleukin-2-activated NK cells that have no MHC (major histocompatibility complex) restriction or need for antigen stimulation. LAK cells are used for adoptive immunotherapy in cancer patients.
C23939	Mouse_Histopathology_Concepts	Retired_Concepts	Murine Histopathology Concepts|Histopathology Concepts
C23940	Mouse_Brunner_s_Glands	Retired_Concepts	Murine Brunner's Glands|Brunner's Glands	Small, flat, granular glands embedded in the submucous areolar tissue of the duodenum.
C23941	Mouse_Vater_s_Ampulla	Retired_Concepts	Murine Vater's Ampulla|Vater's Ampulla	The hepatopancreatic ampulla. A dilation of the duodenal papilla that is the opening of the juncture of the common bile duct and the main pancreatic duct.
C23942	Mouse_Lymphoid_Blood-Forming_Cells	Retired_Concepts	Murine Lymphoid Blood-Forming Cells|Lymphoid Blood-Forming Cells
C23943	Mouse_Lymphoblast	Retired_Concepts	Murine Lymphoblast|Lymphoblast	Blast cells are in an immature (undifferentiated) stage in cellular development, occurring before the appearance of the definitive characteristics exhibited by fully differentiated cells.
C23944	Mouse_Monoblast	Retired_Concepts	Murine Monoblast|Monoblast
C23945	Mouse_Myeloblast	Retired_Concepts	Murine Myeloblast|Myeloblast
C23946	Mouse_Joints	Retired_Concepts	Murine Joints|Joints	is an organ that constitutes an anatomical junction; it consists of two or more adjacent bones, parts of which are interconnected by organ parts that consist of various types of connective tissue. Together with other joints and bones, a joint constitutes the skeletal system. Example(s): pubic symphysis, knee joint, temporomandibular joint.
C23947	Mouse_Tendons	Retired_Concepts	Murine Tendons|Tendons
C23948	Mouse_Ligaments	Retired_Concepts	Murine Ligaments|Ligaments	Shiny, flexible bands of fibrous tissue connecting together articular extremities of bones. They are pliant, tough, and inextensile.
C23949	Mouse_Seminiferous_Tubules	Retired_Concepts	Murine Seminiferous Tubules|Seminiferous Tubules	The canals through which the testicular spermatozoa are conveyed to the rete testis.
C23950	Mouse_Nephron	Retired_Concepts	Murine Nephron|Nephron	The functional units of the kidney, consisting of the glomerulus and the attached tubule.
C23951	Mouse_Lymphoid_Tissue	Retired_Concepts	Murine Lymphoid Tissue|Lymphoid Tissue
C23952	Mouse_Skeletal_Muscle	Retired_Concepts	Murine Skeletal Muscle|Skeletal Muscle	Striated muscles having fibers connected at either or both extremities with the bony framework of the body. These are found in appendicular and axial muscles. (From Stedman, 25th ed)
C23953	Mouse_Hematopoietic_Tissue	Retired_Concepts	Murine Hematopoietic Tissue|Hematopoietic Tissue
C23954	Mouse_Nerve_Tissue	Retired_Concepts	Murine Nerve Tissue|Nerve Tissue
C23955	Mouse_Vascular_Endothelium	Retired_Concepts	Murine Vascular Endothelium|Vascular Endothelium	Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components from interstitium to lumen; this function has been most intensively studied in the blood capillaries.
C23956	Mouse_Embryonic_Cells	Retired_Concepts	Murine Embryonic Cells|Embryonic Cells
C23957	Mouse_Secretory_Cells	Retired_Concepts	Murine Secretory Cells|Secretory Cells
C23958	Mouse_Muscle	Retired_Concepts	Murine Muscle|Muscle
C23959	Mouse_Reticular_Cells	Retired_Concepts	Murine Reticular Cells|Reticular Cells
C23960	Mouse_Special_Sense_Organ_System	Retired_Concepts	Murine Special Sense Organ System|Special Sense Organ System
C23961	Mouse_Synovial_Cells	Retired_Concepts	Murine Synovial Cells|Synovial Cells
C23962	Mouse_Sensory_Ganglia	Retired_Concepts	Murine Sensory Ganglia|Sensory Ganglia	Clusters of neurons in the somatic peripheral nervous system which contain the cell bodies of sensory nerve axons. Sensory ganglia may also have intrinsic interneurons and non-neuronal supporting cells.
C23963	Mouse_Chromaffin_System	Retired_Concepts	Murine Chromaffin System|Chromaffin System	The cells of the body which stain with chromium salts. They occur along the sympathetic nerves, in the adrenal gland, and in various other organs.
C23964	Mouse_Back	Retired_Concepts	Murine Back|Back
C23965	Mouse_Neck	Retired_Concepts	Murine Neck|Neck
C23966	Mouse_Digestive_System	Retired_Concepts	Murine Digestive System|Digestive System|Digestive System (All Sites)	encompasses the mouth, esophagus, stomach, intestines, biliary tract, pancreas, liver, and associated hormones and secretions.
C23967	Mouse_Oddi_s_Sphincter	Retired_Concepts	Murine Oddi's Sphincter|Oddi's Sphincter	The sphincter of the hepatopancreatic ampulla within the duodenal papilla. The COMMON BILE DUCT and main pancreatic duct pass through this sphincter.
C23968	Mouse_Ileocecal_Valve	Retired_Concepts	Murine Ileocecal Valve|Ileocecal Valve
C23969	Mouse_Solitary_Nucleus	Retired_Concepts	Murine Solitary Nucleus|Nucleus Tractus Solitarius|Solitary Nucleus	Gray matter located in the dorsomedial part of the medulla oblongata associated with the solitary tract. The solitary nucleus receives inputs from most organ systems including the terminations of the facial, glossopharyngeal, and vagus nerves. It is a major coordinator of autonomic nervous system regulation of cardiovascular, respiratory, gustatory, gastrointestinal, and chemoreceptive aspects of homeostasis. The solitary nucleus is also notable for the large number of neurotransmitters which are found therein.
C23970	Mouse_Foot_Bones	Retired_Concepts	Murine Foot Bones|Foot Bones	The TARSUS, METATARSUS, and phalanges. The tarsus consists of seven bones: calcaneum, astragalus, cuboid, navicular, internal, middle, and external cuneiform bones. The five METATARSAL BONES are numbered one through five, running medial to lateral. There are 14 phalanges in each foot, the great toe has two while the other toes have three each.
C23971	Mouse_Stomatognathic_System	Retired_Concepts	Murine Stomatognathic System|Stomatognathic System	The mouth, teeth, jaws, pharynx, and related structures as they relate to mastication, deglutition, and speech.
C23972	Mouse_Cheek	Retired_Concepts	Murine Cheek|Cheek
C23973	Mouse_Face	Retired_Concepts	Murine Face|Face	The anterior portion of the head that includes the skin, muscles, and structures of the forehead, eyes, nose, mouth, cheeks, and jaw.
C23974	Mouse_Dentition	Retired_Concepts	Murine Dentition|Dentition	The kind, number, and arrangement of teeth.
C23975	Mouse_Facial_Muscles	Retired_Concepts	Murine Facial Muscles|Facial Muscles	Muscles of facial expression or mimetic muscles that include the numerous muscles supplied by the facial nerve that are attached to and move the skin of the face. (From Stedman, 25th ed)
C23976	Mouse_Masticatory_Muscles	Retired_Concepts	Murine Masticatory Muscles|Masticatory Muscles	Muscles arising in the zygomatic arch that close the jaw. Their nerve supply is masseteric from the mandibular division of the trigeminal nerve. (From Stedman, 25th ed)
C23977	Mouse_Pharyngeal_Muscles	Retired_Concepts	Murine Pharyngeal Muscles|Pharyngeal Muscles	The muscles of the pharynx are the inferior, middle and superior constrictors, salpingopharyngeus, and stylopharyngeus.
C23978	Mouse_Bone_Tissue	Retired_Concepts	Murine Bone Tissue|Bone Tissue
C23979	Mouse_Acinar_Cells	Retired_Concepts	Murine Acinar Cells|Acinar Cells|Aciner Cells	any of the cells lining an acinus; acinus is a general term used to designate a small saclike dilatation, particularly one found in various glands.
C23980	Mouse_Ependyma	Retired_Concepts	Murine Ependyma|Ependyma	A thin membrane that lines the ventricles of the brain and the central canal of the SPINAL CORD.
C23981	Mouse_Neural_Pathways	Retired_Concepts	Murine Neural Pathways|Neural Pathways	Neural tracts connecting one part of the nervous system with another.
C23982	Mouse_Afferent_Pathways	Retired_Concepts	Murine Afferent Pathways|Afferent Pathways	Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.
C23983	Mouse_Efferent_Pathways	Retired_Concepts	Murine Efferent Pathways|Efferent Pathways	Nerve structures through which impulses are conducted from a nerve center toward a peripheral site.
C23984	Mouse_Internal_Capsule	Retired_Concepts	Murine Internal Capsule|Internal Capsule	White matter pathway, flanked by nuclear masses, consisting of both afferent and efferent fibers projecting between the cerebral cortex and the brainstem. It consists of three distinct parts: an anterior limb, posterior limb, and genu.
C23985	Mouse_Medial_Forebrain_Bundle	Retired_Concepts	Murine Medial Forebrain Bundle|Medial Forebrain Bundle	A complex group of fibers arising from the basal olfactory regions, the periamygdaloid region, and the septal nuclei, and passing to the lateral hypothalamus. Some fibers continue into the tegmentum.
C23986	Mouse_Perforant_Pathway	Retired_Concepts	Murine Perforant Pathway|Perforant Pathway	A pathway of fibers originating in the lateral part of the entorhinal area, perforating the subiculum of the hippocampus, and running into the stratum moleculare of the hippocampus, where these fibers synapse with others that go to the dentate gyrus. It is also called the perforating fasciculus. (Dorland, 28th ed)
C23987	Mouse_Cancer-Related_Conditions	Mouse_Pathologic_Diagnoses	Mouse Cancer-Related Conditions|Cancer-Related Conditions
C23988	Mouse_Neoplasms	Mouse_Pathologic_Diagnoses	Mouse Neoplasms|Neoplasms
C23989	Mouse_Noncancerous_Conditions	Mouse_Cancer-Related_Conditions	Mouse Noncancerous Conditions|Noncancerous Conditions
C23990	Mouse_Precancerous_Conditions	Mouse_Cancer-Related_Conditions	Mouse Precancerous Conditions|Precancerous Conditions
C23991	Mouse_Metastatic_Neoplasms	Mouse_Neoplasms	Mouse Metastatic Neoplasms|Metastatic Neoplasms
C23992	Mouse_Neoplasms_by_Histopathology	Mouse_Neoplasms	Mouse Neoplasms by Histopathology|Neoplasms by Histopathology
C23993	Mouse_Neoplasms_by_Location	Mouse_Neoplasms	Mouse Neoplasms by Location|Neoplasms by Location
C23994	Mouse_Neoplasms_by_Cell_Type	Mouse_Neoplasms_by_Histopathology	Mouse Neoplasms by Cell Type|Neoplasms by Cell Type
C23995	Mouse_Neoplasms_by_Morphology	Mouse_Neoplasms_by_Histopathology	Mouse Neoplasms by Morphology|Neoplasms by Morphology
C23996	Mouse_Acinar_Cell_Neoplasm	Mouse_Epithelial_Cell_Neoplasms	Mouse Acinar Cell Neoplasm|Acinar Cell Neoplasm
C23997	Mouse_Ductal_Cell_Neoplasm	Mouse_Neoplasms_by_Cell_Type	Mouse Ductal Cell Neoplasm|Ductal Cell Neoplasm
C23998	Mouse_Epithelial_Cell_Neoplasms	Mouse_Neoplasms_by_Cell_Type	Mouse Epithelial Cell Neoplasms|Epithelial Cell Neoplasms
C23999	Mouse_Germ_Cell_Neoplasm	Mouse_Neoplasms_by_Cell_Type	Mouse Germ Cell Neoplasm|Germ Cell Neoplasm
C24000	Mouse_Granulosa_Cell_Tumor	Mouse_Neoplasms_by_Cell_Type	Mouse Granulosa Cell Tumor|Granulosa Cell Tumor
C24001	Mouse_Lymph_Cell_Neoplasm	Mouse_Neoplasms_by_Cell_Type	Mouse Lymph Cell Neoplasm|Lymph Cell Neoplasm
C24002	Mouse_Melanocyte_Neoplasm	Mouse_Epithelial_Cell_Neoplasms	Mouse Melanocyte Neoplasm|Melanocyte Neoplasm
C24003	Mouse_Mesenchymal_Neoplasm	Mouse_Neoplasms_by_Cell_Type	Mouse Mesenchymal Neoplasm|Mesenchymal Neoplasm
C24004	Mouse_Monocyte_Neoplasm	Mouse_Neoplasms_by_Cell_Type	Mouse Monocyte Neoplasm|Monocyte Neoplasm
C24005	Mouse_Myeloid_Cell_Neoplasm	Mouse_Neoplasms_by_Cell_Type	Mouse Myeloid Cell Neoplasm|Myeloid Cell Neoplasm
C24006	Mouse_Neural_Cell_Neoplasm	Mouse_Neoplasms_by_Cell_Type	Mouse Neural Cell Neoplasm|Neural Cell Neoplasm
C24007	Mouse_Plasma_Cell_Dyscrasia	Mouse_Plasma_Cell_Neoplasm	Mouse Plasma Cell Dyscrasia|Plasma Cell Dyscrasia
C24008	Mouse_Transitional_Cell_Neoplasm	Mouse_Neoplasms_by_Cell_Type	Mouse Transitional Cell Neoplasm|Transitional Cell Neoplasm
C24009	Mouse_Adenoma	Mouse_Benign_Epithelial_Neoplasm|Mouse_Neoplasms_by_Morphology	Mouse Adenoma|Adenoma
C24010	Mouse_Carcinoma	Mouse_Epithelial_Cell_Neoplasms|Mouse_Neoplasms_by_Morphology	Mouse Carcinoma|Carcinoma
C24011	Mouse_Adenocarcinoma	Mouse_Carcinoma	Mouse Adenocarcinoma|Adenocarcinoma
C24012	Mouse_Squamous_Cell_Neoplasm	Mouse_Epithelial_Cell_Neoplasms	Mouse Squamous Cell Neoplasm|Squamous Cell Neoplasm
C24013	Mouse_Adenosquamous_Carcinoma	Mouse_Adenocarcinoma|Mouse_Squamous_Cell_Neoplasm	Mouse Adenosquamous Carcinoma|Adenosquamous Carcinoma
C24014	Mouse_Benign_Epithelial_Neoplasm	Mouse_Epithelial_Cell_Neoplasms	Mouse Benign Epithelial Neoplasm|Benign Epithelial Neoplasm
C24015	Mouse_Papilloma	Mouse_Benign_Epithelial_Neoplasm	Mouse Papilloma|Papilloma
C24016	Mouse_Angiosarcoma	Mouse_Sarcoma	Mouse Angiosarcoma|Angiosarcoma
C24017	Mouse_Fibrosarcoma	Mouse_Sarcoma	Mouse Fibrosarcoma|Fibrosarcoma
C24018	Mouse_Chondrosarcoma	Mouse_Chondrocyte_Neoplasm|Mouse_Sarcoma	Mouse Chondrosarcoma|Chondrosarcoma
C24019	Mouse_Kaposi_s_Sarcoma	Mouse_Sarcoma	Mouse Kaposi's Sarcoma|Kaposi's Sarcoma
C24020	Mouse_Leiomyosarcoma	Mouse_Sarcoma	Mouse Leiomyosarcoma|Leiomyosarcoma
C24021	Mouse_Osteosarcoma	Mouse_Sarcoma	Mouse Osteosarcoma|Osteosarcoma
C24022	Mouse_Rhabdomyosarcoma	Malignant_Mouse_Skeletal_Muscle_Neoplasm|Mouse_Sarcoma	Mouse Rhabdomyosarcoma|Rhabdomyosarcoma
C24023	Mouse_Synovial_Sarcoma	Mouse_Sarcoma	Mouse Synovial Sarcoma|Synovial Sarcoma
C24024	Mouse_Gastrointestinal_System_Neoplasms	Mouse_Digestive_System_Neoplasms	Mouse Gastrointestinal System Neoplasms|Gastrointestinal System Neoplasms
C24025	Mouse_Hepatic_System_Neoplasms	Retired_Concepts	Mouse Hepatic System Neoplasms|Hepatic System Neoplasms
C24026	Mouse_Benign_Hepatic_System_Neoplasms	Retired_Concepts	Mouse Benign Hepatic System Neoplasms|Benign Hepatic System Neoplasms
C24027	Mouse_Malignant_Hepatic_System_Neoplasms	Retired_Concepts	Mouse Malignant Hepatic System Neoplasms|Malignant Hepatic System Neoplasms
C24028	Mouse_Hepatocellular_Adenoma	Retired_Concepts	Mouse Hepatocellular Adenoma|Hepatocellular Adenoma|Mouse Liver Cell Adenoma
C24029	Mouse_Hepatocellular_Carcinoma	Retired_Concepts	Mouse Hepatocellular Carcinoma|Hepatocellular Carcinoma|Mouse Adult Primary Hepatocellular Carcinoma|Mouse Adult Primary Liver Cell Carcinoma|Mouse Liver Cell Carcinoma
C24030	Mouse_Genitourinary_Neoplasms	Mouse_Neoplasms_by_Location	Mouse Genitourinary Neoplasms|Genitourinary Neoplasms
C24031	Mouse_Reproductive_System_Neoplasms	Mouse_Genitourinary_Neoplasms|Mouse_Reproductive_System_Disorder	Mouse Reproductive System Neoplasms|Reproductive System Neoplasms
C24032	Mouse_Male_Reproductive_System_Neoplasms	Mouse_Male_Reproductive_System_Disorder|Mouse_Reproductive_System_Neoplasms	Mouse Male Reproductive System Neoplasms|Male Reproductive System Neoplasms
C24033	Mouse_Female_Reproductive_System_Neoplasms	Mouse_Female_Reproductive_System_Disorder|Mouse_Reproductive_System_Neoplasms	Mouse Female Reproductive System Neoplasms|Female Reproductive System Neoplasms
C24034	Mouse_Digestive_System_Neoplasms	Mouse_Digestive_System_Disorder|Mouse_Neoplasms_by_Location	Mouse Digestive System Neoplasms|Digestive System Neoplasms
C24035	Mouse_Integumentary_System_Neoplasms	Mouse_Neoplasms_by_Location	Mouse Integumentary System Neoplasms
C24036	Mouse_Adrenal_Gland_Neoplasms	Mouse_Endocrine_Gland_System_Neoplasms	Mouse Adrenal Gland Neoplasms|Adrenal Gland Neoplasms
C24037	Mouse_Pituitary_Gland_Neoplasms	Mouse_Endocrine_Gland_System_Neoplasms	Mouse Pituitary Gland Neoplasms|Pituitary Gland Neoplasms
C24038	Mouse_Pancreatic_Neoplasms	Retired_Concepts	Mouse Pancreatic Neoplasms|Pancreatic Neoplasms
C24039	Tumors_of_the_Mouse_Pulmonary_System	Epithelial_Proliferative_Lesions_of_the_Mouse_Pulmonary_System|Mouse_Neoplasms_by_Location	Tumors of the Mouse Pulmonary System|Neoplasms of the Mouse Pulmonary System|Tumors of the Pulmonary System
C24040	Mouse_Special_Sense_Organ_Neoplasms	Mouse_Neoplasms_by_Location	Mouse Special Sense Organ Neoplasms|Special Sense Organ Neoplasms
C24041	Biliary_Tract_MMHCC	Digestive_System_MMHCC	Biliary Tract (MMHCC)
C24042	Bile_Duct_MMHCC	Biliary_Tract_MMHCC	Bile Duct (MMHCC)
C24043	Exocrine_Pancreas_MMHCC	Pancreas_MMHCC	Exocrine Pancreas (MMHCC)
C24044	Pancreas_MMHCC	Digestive_System_MMHCC	Pancreas (MMHCC)
C24045	Exocrine_Pancreas_Ductal_System_MMHCC	Exocrine_Pancreas_MMHCC	Exocrine Pancreas - Ductal System (MMHCC)
C24046	Lateral_Prostate_Gland_MMHCC	Prostate_Gland_MMHCC	Lateral Prostate Gland (MMHCC)
C24047	Dorsal_Prostate_Gland_MMHCC	Prostate_Gland_MMHCC	Dorsal Prostate Gland (MMHCC)
C24048	Ventral_Prostate_Gland_MMHCC	Prostate_Gland_MMHCC	Ventral Prostate Gland (MMHCC)
C24050	Lung_Bronchus_MMHCC	Lung_MMHCC	Lung - Bronchus (MMHCC)
C24051	Mouse_Fallopian_Tube_Neoplasm	Mouse_Female_Reproductive_System_Neoplasms	Mouse Fallopian Tube Neoplasm|Fallopian Tube Neoplasm
C24052	Benign_Mouse_Fallopian_Tube_Neoplasm	Mouse_Fallopian_Tube_Neoplasm	Benign Mouse Fallopian Tube Neoplasm|Benign Fallopian Tube Neoplasm
C24053	Malignant_Mouse_Fallopian_Tube_Neoplasm	Mouse_Fallopian_Tube_Neoplasm	Malignant Mouse Fallopian Tube Neoplasm|Malignant Fallopian Tube Neoplasm
C24054	Mouse_Fallopian_Tube_Carcinoma	Malignant_Mouse_Fallopian_Tube_Neoplasm	Mouse Fallopian Tube Carcinoma|Fallopian Tube Carcinoma
C24055	Mouse_Fallopian_Tube_Adenocarcinoma	Mouse_Fallopian_Tube_Carcinoma	Mouse Fallopian Tube Adenocarcinoma|Fallopian Tube Adenocarcinoma
C24056	Mouse_Fallopian_Tube_Clear_Cell_Adenocarcinoma	Mouse_Fallopian_Tube_Adenocarcinoma	Mouse Fallopian Tube Clear Cell Adenocarcinoma|Fallopian Tube Clear Cell Adenocarcinoma
C24057	Mouse_Fallopian_Tube_Endometrioid_Adenocarcinoma	Mouse_Fallopian_Tube_Adenocarcinoma	Mouse Fallopian Tube Endometrioid Adenocarcinoma|Fallopian Tube Endometrioid Adenocarcinoma
C24058	Mouse_Fallopian_Tube_Mucinous_Adenocarcinoma	Mouse_Fallopian_Tube_Adenocarcinoma	Mouse Fallopian Tube Mucinous Adenocarcinoma|Fallopian Tube Mucinous Adenocarcinoma
C24059	Mouse_Fallopian_Tube_Papillary_Adenocarcinoma	Mouse_Fallopian_Tube_Adenocarcinoma	Mouse Fallopian Tube Papillary Adenocarcinoma|Fallopian Tube Papillary Adenocarcinoma
C24060	Mouse_Fallopian_Tube_Papillary_Serous_Adenocarcinoma	Mouse_Fallopian_Tube_Papillary_Adenocarcinoma	Mouse Fallopian Tube Papillary Serous Adenocarcinoma|Fallopian Tube Papillary Serous Adenocarcinoma
C24061	Mouse_Fallopian_Tube_Serous_Adenocarcinoma	Mouse_Fallopian_Tube_Adenocarcinoma	Mouse Fallopian Tube Serous Adenocarcinoma|Fallopian Tube Serous Adenocarcinoma
C24062	Fallopian_Tube_Papillary_Serous_Adenocarcinoma_of_Mouse	Mouse_Fallopian_Tube_Serous_Adenocarcinoma	Fallopian Tube Papillary Serous Adenocarcinoma of Mouse|Fallopian Tube Papillary Serous Adenocarcinoma
C24063	Mouse_Fallopian_Tube_Gestational_Choriocarcinoma	Mouse_Fallopian_Tube_Carcinoma	Mouse Fallopian Tube Gestational Choriocarcinoma|Fallopian Tube Gestational Choriocarcinoma
C24064	Mouse_Fallopian_Tube_Squamous_Cell_Carcinoma	Mouse_Fallopian_Tube_Carcinoma	Mouse Fallopian Tube Squamous Cell Carcinoma|Fallopian Tube Squamous Cell Carcinoma
C24065	Undifferentiated_Mouse_Fallopian_Tube_Carcinoma	Mouse_Fallopian_Tube_Carcinoma	Undifferentiated Mouse Fallopian Tube Carcinoma|Undifferentiated Fallopian Tube Carcinoma
C24066	Malignant_Mouse_Uterine_Neoplasms	Mouse_Female_Reproductive_System_Neoplasms	Malignant Mouse Uterine Neoplasms|Malignant Uterine Neoplasms
C24067	Malignant_Mouse_Cervical_Neoplasm	Malignant_Mouse_Uterine_Neoplasms	Malignant Mouse Cervical Neoplasm|Malignant Cervical Neoplasm
C24068	Mouse_Cervical_Carcinoma	Malignant_Mouse_Cervical_Neoplasm	Mouse Cervical Carcinoma|Cervical Carcinoma
C24069	Mouse_Cervical_Adenocarcinoma	Mouse_Cervical_Carcinoma	Mouse Cervical Adenocarcinoma|Cervical Adenocarcinoma
C24070	Mouse_Cervical_Adenocarcinoma_in_Situ	Mouse_Cervical_Adenocarcinoma	Mouse Cervical Adenocarcinoma in Situ|Cervical Adenocarcinoma in Situ
C24071	Mouse_Mesonephric_Adenocarcinoma	Mouse_Cervical_Adenocarcinoma	Mouse Mesonephric Adenocarcinoma|Mesonephric Adenocarcinoma
C24072	Mouse_Uterine_Cervix_Clear_Cell_Adenocarcinoma	Mouse_Cervical_Adenocarcinoma	Mouse Uterine Cervix Clear Cell Adenocarcinoma|Uterine Cervix Clear Cell Adenocarcinoma
C24073	Mouse_Uterine_Cervix_Endometrioid_Adenocarcinoma	Mouse_Cervical_Adenocarcinoma	Mouse Uterine Cervix Endometrioid Adenocarcinoma|Uterine Cervix Endometrioid Adenocarcinoma
C24074	Mouse_Cervical_Adenoid_Cystic_Carcinoma	Mouse_Cervical_Carcinoma	Mouse Cervical Adenoid Cystic Carcinoma|Cervical Adenoid Cystic Carcinoma
C24075	Mouse_Cervical_Adenosquamous_Cell_Carcinoma	Mouse_Cervical_Carcinoma	Mouse Cervical Adenosquamous Cell Carcinoma|Cervical Adenosquamous Cell Carcinoma
C24076	Mouse_Cervical_Small_Cell_Carcinoma	Mouse_Cervical_Carcinoma	Mouse Cervical Small Cell Carcinoma|Cervical Small Cell Carcinoma
C24077	Mouse_Cervical_Squamous_Cell_Carcinoma	Mouse_Cervical_Carcinoma	Mouse Cervical Squamous Cell Carcinoma|Cervical Squamous Cell Carcinoma
C24078	Mouse_Endocervical_Carcinoma	Malignant_Mouse_Endocervical_Neoplasm|Mouse_Cervical_Carcinoma	Mouse Endocervical Carcinoma|Endocervical Carcinoma
C24079	Mouse_Exocervical_Carcinoma	Malignant_Mouse_Exocervical_Neoplasm|Mouse_Cervical_Carcinoma	Mouse Exocervical Carcinoma|Exocervical Carcinoma
C24080	Mouse_Infiltrating_Cervical_Carcinoma	Mouse_Cervical_Carcinoma	Mouse Infiltrating Cervical Carcinoma|Infiltrating Cervical Carcinoma
C24081	Mouse_Recurrent_Cervical_Carcinoma	Mouse_Cervical_Carcinoma	Mouse Recurrent Cervical Carcinoma|Recurrent Cervical Carcinoma
C24082	Undifferentiated_Mouse_Cervical_Carcinoma	Mouse_Cervical_Carcinoma	Undifferentiated Mouse Cervical Carcinoma|Undifferentiated Cervical Carcinoma
C24083	Malignant_Mouse_Endocervical_Neoplasm	Malignant_Mouse_Cervical_Neoplasm	Malignant Mouse Endocervical Neoplasm|Malignant Endocervical Neoplasm
C24084	Malignant_Mouse_Exocervical_Neoplasm	Malignant_Mouse_Cervical_Neoplasm	Malignant Mouse Exocervical Neoplasm|Malignant Exocervical Neoplasm
C24085	Metastasis_to_the_Mouse_Cervix	Malignant_Mouse_Cervical_Neoplasm	Metastasis to the Mouse Cervix|Metastasis to the Cervix
C24086	Metastatic_Carcinoma_to_the_Mouse_Uterine_Cervix	Metastasis_to_the_Mouse_Cervix	Metastatic Carcinoma to the Mouse Uterine Cervix|Metastatic Carcinoma to the Uterine Cervix
C24087	Malignant_Mouse_Uterine_Corpus_Neoplasm	Malignant_Mouse_Uterine_Neoplasms	Malignant Mouse Uterine Corpus Neoplasm|Malignant Uterine Corpus Neoplasm
C24088	Mouse_Endometrial_Carcinoma	Malignant_Mouse_Uterine_Corpus_Neoplasm	Mouse Endometrial Carcinoma|Endometrial Carcinoma
C24089	Mouse_Endometrial_Adenocarcinoma	Mouse_Endometrial_Carcinoma	Mouse Endometrial Adenocarcinoma|Endometrial Adenocarcinoma
C24090	Mouse_Endometrial_Adenocarcinoma_with_Squamous_Metaplasia	Mouse_Endometrial_Adenocarcinoma	Mouse Endometrial Adenocarcinoma with Squamous Metaplasia|Endometrial Adenocarcinoma with Squamous Metaplasia
C24091	Mouse_Endometrial_Clear_Cell_Adenocarcinoma	Mouse_Endometrial_Adenocarcinoma	Mouse Endometrial Clear Cell Adenocarcinoma|Endometrial Clear Cell Adenocarcinoma
C24092	Mouse_Endometrial_Endometrioid_Adenocarcinoma	Mouse_Endometrial_Adenocarcinoma	Mouse Endometrial Endometrioid Adenocarcinoma|Endometrial Endometrioid Adenocarcinoma
C24093	Mouse_Endometrial_Mucinous_Adenocarcinoma	Mouse_Endometrial_Adenocarcinoma	Mouse Endometrial Mucinous Adenocarcinoma|Endometrial Mucinous Adenocarcinoma
C24094	Serous_Carcinoma_of_the_Mouse_Endometrium	Mouse_Endometrial_Adenocarcinoma	Serous Carcinoma of the Mouse Endometrium|Serous Carcinoma of the Endometrium
C24095	Papillary_Serous_Carcinoma_of_the_Mouse_Endometrium	Serous_Carcinoma_of_the_Mouse_Endometrium	Papillary Serous Carcinoma of the Mouse Endometrium|Papillary Serous Carcinoma of the Endometrium
C24096	Mouse_Endometrial_Mixed_Carcinoma	Malignant_Mouse_Uterine_Corpus_Mixed_Neoplasm|Mouse_Endometrial_Carcinoma	Mouse Endometrial Mixed Carcinoma|Endometrial Mixed Carcinoma
C24097	Mouse_Endometrial_Adenosquamous_Carcinoma	Mouse_Endometrial_Mixed_Carcinoma	Mouse Endometrial Adenosquamous Carcinoma|Endometrial Adenosquamous Carcinoma
C24098	Mouse_Endometrial_Squamous_Cell_Carcinoma	Mouse_Endometrial_Carcinoma	Mouse Endometrial Squamous Cell Carcinoma|Endometrial Squamous Cell Carcinoma
C24099	Recurrent_Malignant_Mouse_Endometrial_Neoplasm	Mouse_Endometrial_Carcinoma	Recurrent Malignant Mouse Endometrial Neoplasm|Recurrent Malignant Endometrial Neoplasm
C24100	Recurrent_Mouse_Endometrial_Carcinoma	Recurrent_Malignant_Mouse_Endometrial_Neoplasm	Recurrent Mouse Endometrial Carcinoma|Recurrent Endometrial Carcinoma
C24101	Undifferentiated_Mouse_Endometrial_Carcinoma	Mouse_Endometrial_Carcinoma	Undifferentiated Mouse Endometrial Carcinoma|Undifferentiated Endometrial Carcinoma
C24102	Malignant_Mouse_Uterine_Corpus_Mixed_Neoplasm	Malignant_Mouse_Uterine_Corpus_Neoplasm	Malignant Mouse Uterine Corpus Mixed Neoplasm|Malignant Uterine Corpus Mixed Neoplasm
C24103	Mouse_Uterine_Malignant_Mixed_Mesodermal_Mullerian_Tumor	Malignant_Mouse_Uterine_Corpus_Mixed_Neoplasm	Mouse Uterine Malignant Mixed Mesodermal (Mullerian) Tumor|Uterine Malignant Mixed Mesodermal (Mullerian) Tumor
C24104	Mouse_Uterine_Mullerian_Adenosarcoma	Malignant_Mouse_Uterine_Corpus_Mixed_Neoplasm	Mouse Uterine Mullerian Adenosarcoma|Uterine Mullerian Adenosarcoma
C24105	Mouse_Uterine_Choriocarcinoma	Malignant_Mouse_Uterine_Corpus_Neoplasm	Mouse Uterine Choriocarcinoma|Uterine Choriocarcinoma
C24106	Mouse_Uterine_Gestational_Choriocarcinoma	Mouse_Uterine_Choriocarcinoma	Mouse Uterine Gestational Choriocarcinoma|Uterine Gestational Choriocarcinoma
C24107	Mouse_Uterine_Sarcoma	Malignant_Mouse_Uterine_Corpus_Neoplasm	Mouse Uterine Sarcoma|Uterine Sarcoma
C24108	Mouse_Endometrial_Stromal_Sarcoma	Mouse_Uterine_Sarcoma	Mouse Endometrial Stromal Sarcoma|Endometriaul Stromal Sarcoma
C24109	Recurrent_Mouse_Uterine_Sarcoma	Mouse_Endometrial_Stromal_Sarcoma	Recurrent Mouse Uterine Sarcoma|Recurrent Uterine Sarcoma
C24110	Malignant_Mouse_Placental_Neoplasm	Mouse_Female_Reproductive_System_Neoplasms	Malignant Mouse Placental Neoplasm|Malignant Placental Neoplasm
C24111	Metastasis_to_the_Mouse_Placenta	Malignant_Mouse_Placental_Neoplasm	Metastasis to the Mouse Placenta|Metastasis to the Placenta
C24112	Mouse_Placental_Choriocarcinoma	Malignant_Mouse_Placental_Neoplasm	Mouse Placental Choriocarcinoma|Placental Choriocarcinoma
C24113	Mouse_Connective_and_Soft_Tissue_Neoplasms	Mouse_Connective_and_Soft_Tissue_Disorder|Mouse_Neoplasms_by_Location	Mouse Connective and Soft Tissue Neoplasms|Connective and Soft Tissue Neoplasms
C24114	Mouse_Lipomatous_Neoplasm	Mouse_Connective_and_Soft_Tissue_Neoplasms|Mouse_Mesenchymal_Neoplasm	Mouse Lipomatous Neoplasm|Lipomatous Neoplasm
C24115	Malignant_Mouse_Lipomatous_Neoplasm	Mouse_Lipomatous_Neoplasm	Malignant Mouse Lipomatous Neoplasm|Malignant Lipomatous Neoplasm
C24116	Mouse_Soft_Tissue_Neoplasm	Mouse_Connective_and_Soft_Tissue_Neoplasms|Mouse_Mesenchymal_Neoplasm	Mouse Soft Tissue Neoplasm|Soft Tissue Neoplasm
C24117	Mouse_Myomatous_Neoplasm	Mouse_Soft_Tissue_Neoplasm	Mouse Myomatous Neoplasm|Myomatous Neoplasm
C24118	Malignant_Mouse_Muscle_Neoplasm	Mouse_Myomatous_Neoplasm	Malignant Mouse Muscle Neoplasm|Malignant Muscle Neoplasm
C24119	Malignant_Mouse_Smooth_Muscle_Neoplasm	Malignant_Mouse_Muscle_Neoplasm	Malignant Mouse Smooth Muscle Neoplasm|Malignant Smooth Muscle Neoplasm
C24120	Malignant_Mouse_Skeletal_Muscle_Neoplasm	Malignant_Mouse_Muscle_Neoplasm	Malignant Mouse Skeletal Muscle Neoplasm|Malignant Skeletal Muscle Neoplasm
C24121	Mouse_Bile_Duct_Neoplasm	Retired_Concepts	Mouse Bile Duct Neoplasm|Bile Duct Neoplasm
C24122	Mouse_Bile_Duct_Adenoma	Retired_Concepts	Mouse Bile Duct Adenoma|Bile Duct Adenoma
C24123	Mouse_Intrahepatic_Bile_Duct_Adenoma	Retired_Concepts	Mouse Intrahepatic Bile Duct Adenoma|Intrahepatic Bile Duct Adenoma
C24124	Mouse_Extrahepatic_Bile_Duct_Adenoma	Retired_Concepts	Mouse Extrahepatic Bile Duct Adenoma|Extrahepatic Bile Duct Adenoma
C24125	Mouse_Extrahepatic_Bile_Duct_Papillary_Adenoma	Retired_Concepts	Mouse Extrahepatic Bile Duct Papillary Adenoma|Extrahepatic Bile Duct Papillary Adenoma
C24126	Mouse_Extrahepatic_Bile_Duct_Tubular_Adenoma	Retired_Concepts	Mouse Extrahepatic Bile Duct Tubular Adenoma|Extrahepatic Bile Duct Tubular Adenoma
C24127	Mouse_Bile_Duct_Cystadenoma	Retired_Concepts	Mouse Bile Duct Cystadenoma|Bile Duct Cystadenoma
C24128	Mouse_Extrahepatic_Bile_Duct_Cystadenoma	Retired_Concepts	Mouse Extrahepatic Bile Duct Cystadenoma|Extrahepatic Bile Duct Cystadenoma
C24129	Mouse_Intrahepatic_Bile_Duct_Cystadenoma	Retired_Concepts	Mouse Intrahepatic Bile Duct Cystadenoma|Intrahepatic Bile Duct Cystadenoma
C24130	Mouse_Bile_Duct_Papillomatosis	Retired_Concepts	Mouse Bile Duct Papillomatosis|Bile Duct Papillomatosis
C24131	Mouse_Extrahepatic_Bile_Duct_Papillomatosis	Retired_Concepts	Mouse Extrahepatic Bile Duct Papillomatosis|Extrahepatic Bile Duct Papillomatosis
C24132	Mouse_Intrahepatic_Bile_Duct_Papillomatosis	Retired_Concepts	Mouse Intrahepatic Bile Duct Papillomatosis|Intrahepatic Bile Duct Papillomatosis
C24133	Mouse_Extrahepatic_Bile_Duct_Neoplasm	Retired_Concepts	Mouse Extrahepatic Bile Duct Neoplasm|Extrahepatic Bile Duct Neoplasm
C24134	Malignant_Mouse_Extrahepatic_Bile_Duct_Neoplasm	Retired_Concepts	Malignant Mouse Extrahepatic Bile Duct Neoplasm|Malignant Extrahepatic Bile Duct Neoplasm
C24135	Mouse_Bile_Duct_Sarcoma	Retired_Concepts	Mouse Bile Duct Sarcoma|Bile Duct Sarcoma
C24136	Mouse_Extrahepatic_Bile_Duct_Leiomyosarcoma	Retired_Concepts	Mouse Extrahepatic Bile Duct Leiomyosarcoma|Extrahepatic Bile Duct Leiomyosarcoma
C24137	Malignant_Mouse_Extrahepatic_Bile_Duct_Fibrous_Histocytoma	Retired_Concepts	Malignant Mouse Extrahepatic Bile Duct Fibrous Histocytoma|Malignant Extrahepatic Bile Duct Fibrous Histocytoma
C24138	Mouse_Bile_Duct_Rhabdomyosarcoma	Retired_Concepts	Mouse Bile Duct Rhabdomyosarcoma|Bile Duct Rhabdomyosarcoma
C24139	Mouse_Extrahepatic_Bile_Duct_Embryonal_Rhabdomyosarcoma	Retired_Concepts	Mouse Extrahepatic Bile Duct Embryonal Rhabdomyosarcoma|Extrahepatic Bile Duct Embryonal Rhabdomyosarcoma
C24140	Mouse_Extrahepatic_Bile_Duct_Carcinoid_Neoplasm	Retired_Concepts	Mouse Extrahepatic Bile Duct Carcinoid Neoplasm|Extrahepatic Bile Duct Carcinoid Neoplasm
C24141	Mouse_Extrahepatic_Bile_Duct_Carcinoma	Retired_Concepts	Mouse Extrahepatic Bile Duct Carcinoma|Extrahepatic Bile Duct Carcinoma
C24142	Mouse_Adenosquamous_Bile_Duct_Carcinoma	Retired_Concepts	Mouse Adenosquamous Bile Duct Carcinoma|Adenosquamous Bile Duct Carcinoma
C24143	Mouse_Bile_Duct_Mucoepidermoid_Carcinoma	Retired_Concepts	Mouse Bile Duct Mucoepidermoid Carcinoma|Bile Duct Mucoepidermoid Carcinoma
C24144	Mouse_Bile_Duct_Small_Cell_Carcinoma	Retired_Concepts	Mouse Bile Duct Small Cell Carcinoma|Bile Duct Small Cell Carcinoma
C24145	Mouse_Squamous_Cell_Bile_Duct_Carcinoma	Retired_Concepts	Mouse Squamous Cell Bile Duct Carcinoma|Squamous Cell Bile Duct Carcinoma
C24146	Mouse_Gallbladder_Neoplasm	Mouse_Digestive_System_Neoplasms	Mouse Gallbladder Neoplasm|Gallbladder Neoplasm
C24147	Malignant_Mouse_Gallbladder_Neoplasm	Mouse_Gallbladder_Neoplasm	Malignant Mouse Gallbladder Neoplasm|Malignant Gallbladder Neoplasm
C24148	Mouse_Gallbladder_Carcinoma	Malignant_Mouse_Gallbladder_Neoplasm	Mouse Gallbladder Carcinoma|Gallbladder Carcinoma
C24149	Mouse_Gallbladder_Adenocarcinoma	Mouse_Gallbladder_Carcinoma	Mouse Gallbladder Adenocarcinoma|Gallbladder Adenocarcinoma
C24150	Mouse_Gallbladder_Squamous_Cell_Gallbladder	Mouse_Gallbladder_Carcinoma	Mouse Gallbladder Squamous Cell Gallbladder|Gallbladder Squamous Cell Gallbladder
C24151	Mouse_Gallbladder_Small_Cell_Gallbladder	Mouse_Gallbladder_Carcinoma	Mouse Gallbladder Small Cell Gallbladder|Gallbladder Small Cell Gallbladder
C24152	Mouse_Gallbladder_Carcinosarcoma	Malignant_Mouse_Gallbladder_Neoplasm	Mouse Gallbladder Carcinosarcoma|Gallbladder Carcinosarcoma
C24153	Mouse_Gallbladder_Lymphoma	Malignant_Mouse_Gallbladder_Neoplasm	Mouse Gallbladder Lymphoma|Gallbladder Lymphoma
C24154	Mouse_Gallbladder_Mucosa_Associated_Lymphoid_Tissue_Lymphoma	Mouse_Gallbladder_Lymphoma	Mouse Gallbladder Mucosa Associated Lymphoid Tissue Lymphoma|Gallbladder Mucosa Associated Lymphoid Tissue Lymphoma
C24155	Mouse_Gallbladder_Melanoma	Malignant_Mouse_Gallbladder_Neoplasm	Mouse Gallbladder Melanoma|Gallbladder Melanoma
C24156	Mouse_Gallbladder_Sarcoma	Malignant_Mouse_Gallbladder_Neoplasm	Mouse Gallbladder Sarcoma|Gallbladder Sarcoma
C24157	Mouse_Gallbladder_Angiosarcoma	Mouse_Gallbladder_Sarcoma	Mouse Gallbladder Angiosarcoma|Gallbladder Angiosarcoma
C24158	Mouse_Gallbladder_Kaposi_s_Sarcoma	Mouse_Gallbladder_Sarcoma	Mouse Gallbladder Kaposi's Sarcoma|Gallbladder Kaposi's Sarcoma
C24159	Mouse_Gallbladder_Leiomyosarcoma	Mouse_Gallbladder_Sarcoma	Mouse Gallbladder Leiomyosarcoma|Gallbladder Leiomyosarcoma
C24160	Mouse_Gallbladder_Malignant_Fibrous_Histiocytoma	Mouse_Gallbladder_Sarcoma	Mouse Gallbladder Malignant Fibrous Histiocytoma|Gallbladder Malignant Fibrous Histiocytoma
C24161	Rhabdomyosarcoma_of_the_Mouse_Gallbladder	Mouse_Gallbladder_Sarcoma	Rhabdomyosarcoma of the Mouse Gallbladder|Rhabdomyosarcoma of the Gallbladder
C24162	Metastatic_Neoplasm_to_the_Mouse_Gallbladder	Malignant_Mouse_Gallbladder_Neoplasm	Metastatic Neoplasm to the Mouse Gallbladder|Metastatic Neoplasm to the Gallbladder
C24163	Mouse_Thyroid_Neoplasm	Mouse_Endocrine_Gland_System_Neoplasms	Mouse Thyroid Neoplasm|Thyroid Neoplasm
C24164	Malignant_Mouse_Thyroid_Neoplasm	Mouse_Thyroid_Neoplasm	Malignant Mouse Thyroid Neoplasm|Malignant Thyroid Neoplasm
C24165	Metastasis_to_the_Mouse_Thyroid	Malignant_Mouse_Thyroid_Neoplasm	Metastasis to the Mouse Thyroid|Metastasis to the Thyroid
C24166	Mouse_Thyroid_Carcinoma	Malignant_Mouse_Thyroid_Neoplasm	Mouse Thyroid Carcinoma|Thyroid Carcinoma
C24167	Mouse_Anaplastic_Thyroid_Carcinoma	Mouse_Thyroid_Carcinoma	Mouse Anaplastic Thyroid Carcinoma|Anaplastic Thyroid Carcinoma
C24168	Mouse_Anaplastic_Giant_Cell_Thyroid_Carcinoma	Mouse_Anaplastic_Thyroid_Carcinoma	Mouse Anaplastic Giant Cell Thyroid Carcinoma|Anaplastic Giant Cell Thyroid Carcinoma
C24169	Mouse_Anaplastic_Small_Cell_Thyroid_Carcinoma	Mouse_Anaplastic_Thyroid_Carcinoma	Mouse Anaplastic Small Cell Thyroid Carcinoma|Anaplastic Small Cell Thyroid Carcinoma
C24170	Mouse_Medullary_Thyroid_Carcinoma	Mouse_Thyroid_Carcinoma	Mouse Medullary Thyroid Carcinoma|Medullary Thyroid Carcinoma
C24171	Mouse_Medullary_Thyroid_Carcinoma_with_Amyloid_Stroma	Mouse_Medullary_Thyroid_Carcinoma	Mouse Medullary Thyroid Carcinoma with Amyloid Stroma|Medullary Thyroid Carcinoma with Amyloid Stroma
C24172	Poorly_Differentiated_Mouse_Thyroid_Carcinoma	Mouse_Thyroid_Carcinoma	Poorly Differentiated Mouse Thyroid Carcinoma|Poorly Differentiated Thyroid Carcinoma
C24173	Recurrent_Mouse_Thyroid_Carcinoma	Mouse_Thyroid_Carcinoma	Recurrent Mouse Thyroid Carcinoma|Recurrent Thyroid Carcinoma
C24174	Well-Differentiated_Mouse_Thyroid_Carcinoma	Mouse_Thyroid_Carcinoma	Well-Differentiated Mouse Thyroid Carcinoma|Well-Differentiated Thyroid Carcinoma
C24175	Mouse_Follicular_Thyroid_Carcinoma	Well-Differentiated_Mouse_Thyroid_Carcinoma	Mouse Follicular Thyroid Carcinoma|Follicular Thyroid Carcinoma
C24176	Mouse_Trabecular_Follicular_Adenocarcinoma	Mouse_Follicular_Thyroid_Carcinoma	Mouse Trabecular Follicular Adenocarcinoma|Trabecular Follicular Adenocarcinoma
C24177	Mouse_Hurthle_Cell_Carcinoma_of_the_Thyroid	Well-Differentiated_Mouse_Thyroid_Carcinoma	Mouse Hurthle Cell Carcinoma of the Thyroid|Hurthle Cell Carcinoma of the Thyroid
C24178	Mouse_Papillary_Thyroid_Carcinoma	Well-Differentiated_Mouse_Thyroid_Carcinoma	Mouse Papillary Thyroid Carcinoma|Papillary Thyroid Carcinoma
C24179	Mouse_Follicular_Variant_Papillary_Carcinoma	Mouse_Papillary_Thyroid_Carcinoma	Mouse Follicular Variant Papillary Carcinoma|Follicular Variant Papillary Carcinoma
C24180	Mouse_Papillary_and_Follicular_Adenocarcinoma	Well-Differentiated_Mouse_Thyroid_Carcinoma	Mouse Papillary and Follicular Adenocarcinoma|Papillary and Follicular Adenocarcinoma
C24181	Mouse_Thyroid_Lymphoma	Malignant_Mouse_Thyroid_Neoplasm	Mouse Thyroid Lymphoma|Thyroid Lymphoma
C24182	Mouse_Thyroid_Hodgkin_s_Lymphoma	Mouse_Thyroid_Lymphoma	Mouse Thyroid Hodgkin's Lymphoma|Thyroid Hodgkin's Lymphoma
C24183	Mouse_Thyroid_Non-Hodgkin_s_Lymphoma	Mouse_Thyroid_Lymphoma	Mouse Thyroid Non-Hodgkin's Lymphoma|Thyroid Non-Hodgkin's Lymphoma
C24184	Mouse_Thyroid_Diffuse_Large_B-Cell_Lymphoma	Mouse_Thyroid_Non-Hodgkin_s_Lymphoma	Mouse Thyroid Diffuse Large B-Cell Lymphoma|Thyroid Diffuse Large B-Cell Lymphoma
C24185	Mouse_Thyroid_Immunoblastic_Lymphoma	Mouse_Thyroid_Diffuse_Large_B-Cell_Lymphoma	Mouse Thyroid Immunoblastic Lymphoma|Thyroid Immunoblastic Lymphoma
C24186	Mouse_Thyroid_Plasmacytoma	Malignant_Mouse_Thyroid_Neoplasm	Mouse Thyroid Plasmacytoma|Thyroid Plasmacytoma
C24187	Mouse_Thyroid_Sarcoma	Malignant_Mouse_Thyroid_Neoplasm	Mouse Thyroid Sarcoma|Thyroid Sarcoma
C24188	Mouse_Thyroid_Angiosarcoma	Mouse_Thyroid_Sarcoma	Mouse Thyroid Angiosarcoma|Thyroid Angiosarcoma
C24189	PNS_Motor_and_Sensory_Nerves_MMHCC	Nerve_MMHCC	PNS - Motor and Sensory Nerves (MMHCC)|Motor and Sensory Nerves
C24190	Autonomic_Nerves_MMHCC	Nerve_MMHCC	Autonomic Nerves (MMHCC)|Autonomic Nerves
C24191	Dendritic_Cell_Langerhans_Cell_MMHCC	Dendritic_Cell_MMHCC	Dendritic Cell - Langerhans Cell (MMHCC)|Langerhans Cell
C24192	Reproductive_System_MMHCC	Murine_Tissue_Type	Reproductive System (MMHCC)
C24193	Germ_Cell_MMHCC	Reproductive_System_MMHCC	Germ Cell (MMHCC)
C24194	Musculoskeletal_System_MMHCC	Murine_Tissue_Type	Musculoskeletal System (MMHCC)
C24195	Embryonic_Tissue_MMHCC	Murine_Tissue_Type	Embryonic Tissue (MMHCC)
C24196	Embryonic_Tissue_MEF_MMHCC	Embryonic_Tissue_MMHCC	Embryonic Tissue - MEF (MMHCC)|Mouse Embryonic Fibroblast
C24197	Mouse_Chondrocyte_Neoplasm	Mouse_Chondrogenic_Neoplasm|Mouse_Mesenchymal_Neoplasm	Mouse Chondrocyte Neoplasm|Chondrocyte Neoplasm
C24198	Connective_Tissue_Reticular_Cells_MMHCC	Connective_Tissue_MMHCC	Connective Tissue - Reticular Cells (MMHCC)
C24199	Mouse_Chondrogenic_Neoplasm	Mouse_Connective_and_Soft_Tissue_Neoplasms	Mouse Chondrogenic Neoplasm|Chondrogenic Neoplasm
C24200	Mouse_Gastric_Neoplasm	Mouse_Gastrointestinal_System_Neoplasms	Mouse Gastric Neoplasm|Gastric Neoplasm
C24201	Benign_Mouse_Gastric_Neoplasm	Mouse_Gastric_Neoplasm	Benign Mouse Gastric Neoplasm|Benign Gastric Neoplasm
C24202	Benign_Mouse_Gastric_Gastrointestinal_Stromal_Neoplasm	Benign_Mouse_Gastric_Neoplasm|Mouse_Gastric_Gastrointestinal_Stromal_Tumor	Benign Mouse Gastric Gastrointestinal Stromal Neoplasm|Benign Gastric Gastrointestinal Stromal Neoplasm
C24203	Benign_Mouse_Gastric_Granular_Cell_Tumor	Benign_Mouse_Gastric_Neoplasm	Benign Mouse Gastric Granular Cell Tumor|Benign Gastric Granular Cell Tumor
C24204	Mouse_Gastric_Hamartoma	Benign_Mouse_Gastric_Neoplasm	Mouse Gastric Hamartoma|Gastric Hamartoma
C24205	Mouse_Gastric_Leiomyoma	Benign_Mouse_Gastric_Neoplasm|Mouse_Gastric_Mesenchymal_Neoplasm	Mouse Gastric Leiomyoma|Gastric Leiomyoma
C24206	Mouse_Gastric_Epithelioid_Leiomyoma	Mouse_Gastric_Leiomyoma	Mouse Gastric Epithelioid Leiomyoma|Gastric Epithelioid Leiomyoma
C24207	Mouse_Gastric_Lipoma	Benign_Mouse_Gastric_Neoplasm	Mouse Gastric Lipoma|Gastric Lipoma
C24208	Mouse_Gastric_Germ_Cell_Neoplasm	Mouse_Gastric_Neoplasm	Mouse Gastric Germ Cell Neoplasm|Gastric Germ Cell Neoplasm
C24209	Malignant_Mouse_Gastric_Germ_Cell_Neoplasm	Malignant_Mouse_Gastric_Neoplasm|Mouse_Gastric_Germ_Cell_Neoplasm	Malignant Mouse Gastric Germ Cell Neoplasm|Malignant Gastric Germ Cell Neoplasm
C24210	Immature_Mouse_Gastric_Teratoma	Malignant_Mouse_Gastric_Germ_Cell_Neoplasm|Mouse_Gastric_Teratoma	Immature Mouse Gastric Teratoma|Immature Gastric Teratoma
C24211	Mouse_Gastric_Mesenchymal_Neoplasm	Mouse_Gastric_Neoplasm	Mouse Gastric Mesenchymal Neoplasm|Gastric Mesenchymal Neoplasm
C24212	Mouse_Gastric_Gastrointestinal_Stromal_Tumor	Mouse_Gastric_Mesenchymal_Neoplasm	Mouse Gastric Gastrointestinal Stromal Tumor|Gastric Gastrointestinal Stromal Tumor
C24213	Malignant_Mouse_Gastric_Gastrointestinal_Stromal_Tumor	Malignant_Mouse_Gastric_Neoplasm|Mouse_Gastric_Gastrointestinal_Stromal_Tumor	Malignant Mouse Gastric Gastrointestinal Stromal Tumor|Malignant Gastric Gastrointestinal Stromal Tumor
C24214	Mouse_Gastric_Hemangioma	Mouse_Gastric_Mesenchymal_Neoplasm	Mouse Gastric Hemangioma|Gastric Hemangioma
C24215	Mouse_Gastric_Inflammatory_Myofibroblastic_Neoplasm	Mouse_Gastric_Mesenchymal_Neoplasm	Mouse Gastric Inflammatory Myofibroblastic Neoplasm|Gastric Inflammatory Myofibroblastic Neoplasm
C24216	Mouse_Gastric_Liposarcoma	Mouse_Gastric_Mesenchymal_Neoplasm	Mouse Gastric Liposarcoma|Gastric Liposarcoma
C24217	Mouse_Gastric_Xanthoma	Mouse_Gastric_Mesenchymal_Neoplasm	Mouse Gastric Xanthoma|Gastric Xanthoma
C24218	Malignant_Mouse_Gastric_Fibrous_Histocytoma	Mouse_Gastric_Mesenchymal_Neoplasm	Malignant Mouse Gastric Fibrous Histocytoma|Malignant Gastric Fibrous Histocytoma
C24219	Mouse_Gastric_Neuroendocrine_Neoplasm	Mouse_Gastric_Neoplasm	Mouse Gastric Neuroendocrine Neoplasm|Gastric Neuroendocrine Neoplasm
C24220	Mouse_Gastric_Carcinoid_Neoplasm	Mouse_Gastric_Neuroendocrine_Neoplasm	Mouse Gastric Carcinoid Neoplasm|Gastric Carcinoid Neoplasm
C24221	Mouse_Gastric_Small_Cell_Carcinoma	Mouse_Gastric_Carcinoma|Mouse_Gastric_Neuroendocrine_Neoplasm	Mouse Gastric Small Cell Carcinoma|Gastric Small Cell Carcinoma
C24222	Mouse_Gastric_Teratoma	Mouse_Gastric_Neoplasm	Mouse Gastric Teratoma|Gastric Teratoma
C24223	Mature_Mouse_Gastric_Teratoma	Mouse_Gastric_Teratoma	Mature Mouse Gastric Teratoma|Mature Gastric Teratoma
C24224	Malignant_Mouse_Gastric_Neoplasm	Mouse_Gastric_Neoplasm	Malignant Mouse Gastric Neoplasm|Malignant Gastric Neoplasm
C24225	Mouse_Gastric_Carcinoma	Malignant_Mouse_Gastric_Neoplasm	Mouse Gastric Carcinoma|Gastric Carcinoma
C24226	Carcinoma_in_situ_of_the_Mouse_Antrum	Mouse_Gastric_Carcinoma	Carcinoma in situ of the Mouse Antrum|Carcinoma in situ of the Antrum
C24227	Mouse_Gastric_Adenocarcinoma	Mouse_Gastric_Carcinoma	Mouse Gastric Adenocarcinoma|Gastric Adenocarcinoma
C24228	Mouse_Gastric_Adenosquamous_Carcinoma	Mouse_Gastric_Carcinoma	Mouse Gastric Adenosquamous Carcinoma|Gastric Adenosquamous Carcinoma
C24229	Mouse_Gastric_Body_Carcinoma	Mouse_Gastric_Carcinoma	Mouse Gastric Body Carcinoma|Gastric Body Carcinoma
C24230	Mouse_Gastric_Cardia_Carcinoma	Mouse_Gastric_Carcinoma	Mouse Gastric Cardia Carcinoma|Gastric Cardia Carcinoma
C24231	Mouse_Gastric_Fundus_Carcinoma	Mouse_Gastric_Carcinoma	Mouse Gastric Fundus Carcinoma|Gastric Fundus Carcinoma
C24232	Mouse_Gastric_Kaposi_s_Sarcoma	Mouse_Gastric_Carcinoma	Mouse Gastric Kaposi's Sarcoma|Gastric Kaposi's Sarcoma
C24233	Mouse_Gastric_Pylorus_Carcinoma	Mouse_Gastric_Carcinoma	Mouse Gastric Pylorus Carcinoma|Gastric Pylorus Carcinoma
C24234	Mouse_Gastric_Squamous_Cell_Carcinoma	Mouse_Gastric_Carcinoma	Mouse Gastric Squamous Cell Carcinoma|Gastric Squamous Cell Carcinoma
C24235	Recurrent_Mouse_Gastric_Cancer	Mouse_Gastric_Carcinoma	Recurrent Mouse Gastric Cancer|Recurrent Gastric Cancer
C24236	Mouse_Gastric_Lymphoma	Malignant_Mouse_Gastric_Neoplasm	Mouse Gastric Lymphoma|Gastric Lymphoma
C24237	Mouse_Gastric_Hodgkin_s_Lymphoma	Mouse_Gastric_Lymphoma	Mouse Gastric Hodgkin's Lymphoma|Gastric Hodgkin's Lymphoma
C24238	Primary_Mouse_Gastric_Non-Hodgkin_s_Lymphoma	Mouse_Gastric_Lymphoma	Primary Mouse Gastric Non-Hodgkin's Lymphoma|Primary Gastric Non-Hodgkin's Lymphoma
C24239	Secondary_Mouse_Gastric_Non-Hodgkin_s_Lymphoma	Mouse_Gastric_Lymphoma	Secondary Mouse Gastric Non-Hodgkin's Lymphoma|Secondary Gastric Non-Hodgkin's Lymphoma
C24240	Malignant_Mouse_Gastric_Cardio-Esophageal_Junction_Neoplasm	Malignant_Mouse_Gastric_Neoplasm	Malignant Mouse Gastric Cardio-Esophageal Junction Neoplasm|Malignant Gastric Cardio-Esophageal Junction Neoplasm
C24241	Mouse_Barrett_s_Adenocarcinoma	Malignant_Mouse_Gastric_Cardio-Esophageal_Junction_Neoplasm	Mouse Barrett's Adenocarcinoma|Barrett's Adenocarcinoma
C24242	Malignant_Mouse_Gastric_Granular_Cell_Tumor	Malignant_Mouse_Gastric_Neoplasm	Malignant Mouse Gastric Granular Cell Tumor|Malignant Gastric Granular Cell Tumor
C24243	Mixed_Malignant_Mouse_Gastric_Neoplasm	Malignant_Mouse_Gastric_Neoplasm	Mixed Malignant Mouse Gastric Neoplasm|Mixed Malignant Gastric Neoplasm
C24244	Mouse_Gastric_Carcinosarcoma	Mixed_Malignant_Mouse_Gastric_Neoplasm	Mouse Gastric Carcinosarcoma|Gastric Carcinosarcoma
C24245	ANXA5_Gene	Ion_Channel_Protein_Gene	ANXA5 Gene|ANX5|ANX5 Gene|ANXA5|Anchorin CII Gene|Annexin A5 Gene|ENX2|ENX2 Gene|Endonexin II Gene|Lipocortin V Gene|PP4|PP4 Gene|Placental Anticoagulant Protein I Gene	Annexin V belongs to the annexin family of calcium-dependent phospholipid binding proteins some of which have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin V is a phospholipase A2 and protein kinase C inhibitory protein with calcium channel activity and a potential role in cellular signal transduction, inflammation, growth and differentiation. The gene spans 29 kb containing 13 exons, and encodes a single transcript of approximately 1.6 kb and a protein product with a molecular weight of about 35 kDa. (LocusLink)
C24246	ARRB1_Gene	Signaling_Pathway_Gene	ARRB1 Gene|ARB1|ARR1|ARRB1|Arrestin, Beta 1 Gene	Human Arrestin Beta 1 Gene at 11q13 encodes Beta-Arrestin 1 (Arrestin family), which regulates Beta-Adrenergic receptor function.  Two isoforms are produced by alternative splicing.  Beta-Arrestins appear to bind phosphorylated Beta-Adrenergic receptors, impairing G(s) protein activation.  (Swiss-Prot and NCI)
C24247	ATP8A2_Gene	Gene_with_Unknown_or_Unclassified_Function	ATP8A2 Gene|ATP|ATP8A2|ATPIB|ATPase, Aminophospholipid Transporter-Like, Class I, Type 8A, Member 2 Gene|DKFZP434B1913|IB|ML-1	Cloned by similarity to P-type ATPases, proteins that drive uphill transport of ions across membranes. Transfection of antisense constructs into a nontumorigenic cell line rendered the cells tumorigenic in nude mice. The gene is in a chromosomal region frequently deleted in human neoplasms. (from OMIM)
C24248	AVP_Gene	Peptide_Hormone_Gene	AVP Gene|ADH|ARVP|AVP|AVP-NPII|AVRP|Arginine Vasopressin (Neurophysin II, Antidiuretic Hormone, Diabetes Insipidus, Neurohypophyseal) Gene|VP	This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin II and a glycopeptide, copeptin.  Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI).
C24249	AVPR1A_Gene	G_Protein-Coupled_Receptor_Gene	AVPR1A Gene|AVPR1|AVPR1A|Arginine Vasopressin Receptor 1A Gene	The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis. (LocusLink)
C24250	AVPR1B_Gene	G_Protein-Coupled_Receptor_Gene	AVPR1B Gene|AVPR1B|AVPR3|Arginine Vasopressin Receptor 1B Gene	The protein encoded by this gene acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known.
C24251	AVPR2_Gene	G_Protein-Coupled_Receptor_Gene	AVPR2 Gene|ADHR|AVPR2|Arginine Vasopressin Receptor 2 (Nephrogenic Diabetes Insipidus) Gene|DI1|DIR|NDI|V2R	The human AVPR2 locus encodes the vasopressin receptor, type 2, also known as the V2 receptor. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. AVPR2 expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. (LocusLink)
C24252	BAG4_Gene	Signaling_Pathway_Gene	BAG4 Gene|BAG-4|BAG4|BCL2-Associated Athanogene 4 Gene|SODD	The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. (LocusLink)
C24253	BAG5_Gene	Signaling_Pathway_Gene	BAG5 Gene|BAG-5|BAG5|BCL2-Associated Athanogene 5 Gene|KIAA0873	The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. The function of this gene, however, is unknown. (LocusLink)
C24254	BAI1_Gene	Signaling_Pathway_Gene	BAI1 Gene|BAI1|Brain-Specific Angiogenesis Inhibitor 1 Gene	This gene encodes Brain-specific Angiogenesis Inhibitor 1, a seven-span transmembrane protein.  BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. (LocusLink)
C24255	BAI2_Gene	Regulatory_Gene	BAI2 Gene|BAI2|Brain-Specific Angiogenesis Inhibitor 2 Gene	Brain-specific angiogenesis protein BAI2 is similar to BAI1 in structure, has similar tissue specificities and may also play a role in angiogenesis. (LocusLink)
C24256	BAI3_Gene	Regulatory_Gene	BAI3 Gene|BAI3|Brain-Specific Angiogenesis Inhibitor 3 Gene|KIAA0550	Brain-specific angiogenesis protein BAI3 is similar to BAI1 in structure, has similar tissue specificities and may also play a role in angiogenesis. (LocusLink)
C24257	BAIAP1_Gene	Membrane-Associated_Guanylate_Kinase_Family_Gene	BAIAP1 Gene|AIP3|BAI1-Associated Protein 1 Gene|BAIAP1|BAP1|MAGI-1|TNRC19|WWP3	The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. Characterized by two WW domains, a guanylate kinase domain, and five PDZ domains, this protein interacts with the cytoplasmic region of BAI1. Together, these proteins may play a role in cell adhesion and signal transduction. (LocusLink)
C24258	BAIAP2_Gene	Ligand_Binding_Protein_Gene	BAIAP2 Gene|BAI1-Associated Protein 2 Gene|BAIAP2|IRSP53	The protein encoded by this gene has been identified as a brain-specific angiogenesis inhibitor (BAI1)-binding protein. This interaction at the cytoplasmic membrane is crucial to the function of this protein, which may be involved in neuronal growth-cone guidance. This protein functions as an insulin receptor tyrosine kinase substrate and suggests a role for insulin in the central nervous system. This protein has also been identified as interacting with the dentatorubral-pallidoluysian atrophy gene, which is associated with an autosomal dominant neurodegenerative disease. It also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. Alternative splicing of the 3'-end of this gene results in three products of undetermined function. (LocusLink)
C24259	BCL10_Gene	Apoptosis_Promoter_Gene	BCL10 Gene|B-Cell CLL/Lymphoma 10 Gene|BCL10|CARMEN|CIPER|CLAP|c-E10|mE10	This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. (LocusLink)
C24260	BCL6_Gene	Transcription_Factor_Gene	BCL6 Gene|B-Cell CLL/Lymphoma 6 (Zinc Finger Protein 51) Gene|B-Cell CLL/Lymphoma-6 Gene|BCL5|BCL6|Cys-His2 Zinc Finger Transcription Factor Gene|LAZ-3 Gene|LAZ3|Lymphoma-Associated Zinc Finger Gene on Chromosome 3|ZNF51|ZNF51 Gene|Zinc Finger Protein 51 Gene	The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Two alternatively spliced transcript variants that encode the identical protein have been reported for this gene. (LocusLink)
C24261	BCL7A_Gene	Gene_with_Unknown_or_Unclassified_Function	BCL7A Gene|B-Cell CLL/Lymphoma 7A Gene|BCL7|BCL7A	Widely expressed (3.8-kb transcript) 34-kb human BCL7A Gene at 12q24.13 encodes 231-aa 25-kD serine-rich BCL7A Protein, having 90% sequence identity (N-terminal 51-aa) with BCL7B and BCL7C; possible members of an evolutionarily conserved family. BCL7A exhibits no recognizable motifs but shows homology with actin-binding Caldesmon. BCL7A is the site of a recurrent breakpoint, with MYC and IGH, in a three-way translocation in a high-grade B cell non-Hodgkin (Burkitt) lymphoma; the N-terminal BCL7A region is disrupted. (NCI)
C24262	BCL9_Gene	Signaling_Pathway_Gene	BCL9 Gene|B-Cell CLL/Lymphoma 9 Gene|BCL9|LGS	Expressed in thymus, prostate, testis, ovary, small intestine, spleen, colon, and blood, 85-kb human BCL9 Gene at 1q21 encodes 1426-aa 150-kD nuclear B-Cell Lymphoma 9 Protein, containing an HD1 domain that interacts with the conserved PHD finger of PYGO1 and PYGO2. BCL9 (Lgs homolog, Drosophila) also binds to beta-Catenin, involved in WNT signal transduction pathway control of many fundamental developmental processes. BCL9 recruitment of PYGO to beta-Catenin may permit association with DNA-binding TCF to transcriptionally activate WNT target genes. BCL9 translocation that leaves the coding region intact is associated with B-cell acute lymphoblastic leukemia.  (NCI)
C24263	WDR22_Gene	Gene_with_Unknown_or_Unclassified_Function	WDR22 Gene|BCRG2|BCRP2|D14S1461E|KIAA1824|WD Repeat Domain 22 Gene|WDR22	Cloned from the region of a translocation breakpoint from a leiomyoma primary culture. (from OMIM)
C24264	BDKRB2_Gene	G_Protein-Coupled_Receptor_Gene	BDKRB2 Gene|B2R|BDKRB2|BK-2|BK2|BKR2|BRB2|Bradykinin Receptor B2 Gene	The BDKRB2 gene encodes Bradykinin Receptor B2, which is a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. (from LocusLink)
C24265	BIN1_Gene	Adaptor_Signaling_Protein_Gene	BIN1 Gene|AMPH2|AMPHL|BIN1|Bridging Integrator 1 Gene|DKFZp547F068|MGC10367|SH3P9	This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Although the gene is ubiquitously expressed, at least one isoform is concentrated in nerve terminals. Different isoforms of this protein exhibit differential binding to dynamin, synaptojanin, endophilin, and clathrin, and the protein is thought to play a role in protein targeting during synaptic vesicle endocytosis. Alternate splicing of the gene results in ten transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. (LocusLink)
C24266	BLR1_Gene	Chemokine_Receptor_Gene	BLR1 Gene|BLR1|Burkitt Lymphoma Receptor 1, GTP Binding Protein (Chemokine (C-X-C motif) Receptor 5) Gene|CXCR-5|CXCR5|MDR15	This gene was identified as a gene specifically expressed in Burkitt's lymphoma and lymphatic tissues. The protein encoded by this gene is predicted to be a seven transmembrane G protein-coupled receptor and belongs to the CXC chemokine receptor family. BLC, a B-lymphocyte chemoattractant, was identified to be a specific ligand for this receptor. Studies of this gene and its mouse counterpart strongly suggest the essential function of this gene in B cell migration and localization within specific anatomic compartments, such as follicles in lymph nodes as well as in spleen. Two alternatively spliced variants of this gene exist. (LocusLink)
C24267	CCM1_Gene	Signaling_Pathway_Gene	KRIT1 Gene|CAM|CCM1|CCM1 Gene|KRIT1|KRIT1, Ankyrin Repeat Containing Gene	The CCM1 gene at chromosome 7q21-q22 encodes Ankyrin Repeat-Containing Protein KRIT1, which interacts with ICAP-1 and may be involved in bidirectional signaling between integrin molecules and the cytoskeleton. KRIT1 may help determine endothelial cell shape and function in response to cell-cell and cell-matrix interactions by guiding cytoskeletal structure. Defects in the CCM1 gene are responsible for the development of cerebral cavernous malformations, a relatively rare disease causing vascular malformations that may involve any part of the central nervous system. KRIT1 may affect cell adhesion processes via integrin signaling in CCM1 pathogenesis. KRIT1 also interacts with RAP1A (a member of the Ras family of GTPases) and may be involved in the RAP1A signal transduction pathway in vasculogenesis or angiogenesis. KRIT1 contains 4 ankyrin repeats, 1 band 4.1-like domain, and 1 FERM domain. (From NCI)
C24268	CCNB2_Gene	Cyclin_Gene	CCNB2 Gene|CCNB2|Cyclin B2 Gene	The CCNB2 gene at chromosome 15q21.2 encodes Cyclin B2, a member of the cyclin family of CDK kinase regulatory subunits, specifically the B-type cyclins. Cyclin B2 is primarily associated with the Golgi region. Cyclin B2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. Cyclin B2 interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex, activating and imparting substrate specificity to the complex. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/CDC2 may play a key role in transforming growth factor beta-mediated cell cycle control. Cyclin B2 accumulates steadily during G2 and is abruptly destroyed at mitosis. Overexpression of cyclins B, resulting from different mechanisms, could contribute, through an alteration of the spindle checkpoint, to the chromosomal instability observed in cancer. (From LocusLink, PMID and NCI)
C24269	CCR1_Gene	Chemokine_Receptor_Gene	CCR1 Gene|C-C CKR-1 Gene|C-C Chemokine Receptor Type 1 Gene|CC-CKR-1 Gene|CCR-1 Gene|CCR1|CKR-1 Gene|CMKBR1 Gene|CMKR1 Gene|Chemokine (C-C Motif) Receptor 1 Gene|HM145 Gene|LD78 Receptor Gene|MIP-1Alpha-R Gene|MIP1aR Gene|Macrophage Inflammatory Protein-1 Alpha Receptor Gene|RANTES Receptor Gene|RANTES-R Gene	The CCR1 gene at 3p21 encodes Chemokine (C-C Motif) Receptor 1, a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene may have roles in host protection from inflammatory response, and susceptibility to virus and parasite. (From LocusLink and NCI)
C24270	CCR5_Gene	Chemokine_Receptor_Gene	CCR5 Gene|C-C CKR-5 Gene|C-C Chemokine Receptor Type 5 Gene|CC-CKR-5 Gene|CCCKR5 Gene|CCR-5 Gene|CCR5|CD195 Antigen Gene|CHEMR13 Gene|CKR-5 Gene|CKR5 Gene|CMKBR5 Gene|Chemokine (C-C) Receptor 5 Gene|HIV-1 Fusion Co-Receptor Gene	The CCR5 gene at 3p21 encodes Chemokine (C-C Motif) Receptor 5, a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. This receptor is expressed by T cells and macrophages, and is an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene is associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene is also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. (From LocusLink and NCI)
C24271	CCR6_Gene	Chemokine_Receptor_Gene	CCR6 Gene|BN-1 Gene|C-C CKR-6 Gene|C-C Chemokine Receptor Type 6 Gene|CC-CKR-6 Gene|CCR-6 Gene|CCR6|CKR-L3 Gene|CKR6 Gene|CKRL3 Gene|CMKBR6 Gene|Chemokine (C-C) Receptor 6 Gene|Chemokine Receptor-Like 3 Gene|DCR2 Gene|DRY-6 Gene|DRY6 Gene|G Protein-Coupled Receptor 29 Gene|GPR-CY4 Gene|GPR29 Gene|GPRCY4 Gene|LARC Receptor Gene|STRL22 Gene|Seven-Transmembrane Receptor, Lymphocyte, 22 Gene	The CCR6 gene at 6q27 encodes Chemokine (C-C Motif) Receptor 6, a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. The CCR6 gene is preferentially expressed by immature dendritic cells and memory T cells. This receptor mediates intracellular calcium flux and binds specifically to the CC chemokine macrophage inflammatory protein 3 alpha (MIP-3 alpha). It is important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. (From LocusLink and NCI)
C24272	CCR8_Gene	Chemokine_Receptor_Gene	CCR8 Gene|CCR8|CKR-L1|CKRL1|CMKBR8|CMKBRL2|CY6|Chemokine (C-C motif) Ligand 8 Gene|GPR-CY6|TER1	The CCR8 gene at 3p22 encodes Chemokine (C-C Motif) Receptor 8, a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. This receptor is expressed preferentially in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) are ligands of this receptor. This receptor and its ligands regulate monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. (From LocusLink and NCI)
C24273	CCR9_Gene	Chemokine_Receptor_Gene	CCR9 Gene|C-C CKR-9|CC-CKR-9|CCR-9|CCR9|Chemokine (C-C Motif) Receptor 9 Gene|GPR-9-6	Differentially expressed by T lymphocytes in small intestine and colon as well as in thymus, lymph nodes, and spleen, human CCR9 Gene (GPCR1/Beta Chemokine Receptor Family) encodes two variants of C-C Chemokine Receptor Type 9, a seven transmembrane G protein-coupled receptor and regulator of thymocyte migration/recruitment and development that may promote specialization of immune responses and inflammation in different regions of the gastrointestinal tract. CCR9 mediates intracellular calcium flux and specifically binds to CC chemokine TECK/CCL25 ligand. (From LocusLink and NCI)
C24274	CCRL1_Gene	Chemokine_Receptor_Gene	CCRL1 Gene|C-C CKR-11|C-C CKR-11 Gene|C-C Chemokine Receptor Type 11 Gene|CC-CKR-11|CC-CKR-11 Gene|CCBP2|CCBP2 Gene|CCR-11|CCR-11 Gene|CCR11|CCR11 Gene|CCRL1|CCX CKR|CCX CKR Gene|CCX-CKR|CCX-CKR Gene|Chemokine (C-C Motif) Receptor-Like 1 Gene|Chemokine Receptor-Like 1 Gene|PPR1|PPR1 Gene|VSHK1|VSHK1 Gene	The CCRL1 gene at chromosome 3q22 encodes Chemokine (C-C Motif) Receptor-Like 1, which is a G protein-coupled receptor that binds chemokines of the CC subfamily, especially MCP-4, ELC (SCYA19) and TECK (SCYA25). CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. Predominant expression of 5.0, 2.0 and 1.3kb mRNA forms exist in human heart tissue, while low-level expression of the 2.0 and 1.3kb forms in lung, pancreas and spleen and in fetal tissues. The CCRL1 gene has one intron in the 5' untranslated region. Coupled transcription-translation of CCRL1 cDNA yielded a 45kD glycosylated protein. (From LocusLink, OMIM, and NCI)
C24275	CCRL2_Gene	Chemokine_Receptor_Gene	CCRL2 Gene|CCRL2|CKRX|CRAM-A|CRAM-B|Chemokine (C-C Motif) Receptor-Like 2 Gene|HCR	The CCRL2 gene at 3p21 encodes Chemokine (C-C Motif) Receptor-Like 2, a seven transmembrane chemokine receptor like protein that is most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. (From LocusLink, OMIM, and NCI)
C24276	CCXCR1_Gene	Retired_Concepts	CCXCR1 Gene
C24277	CD3E_Gene	Protein_Complex_Subunit_Gene	CD3E Gene|CD3-Epsilon Gene|CD3E|CD3E Antigen, Epsilon Polypeptide (TIT3 Complex) Gene|T-Cell Antigen Receptor Complex, Epsilon Subunit of T3 Gene|T-Cell Surface Antigen T3/LEU-4 Epsilon Chain Gene|T-Cell Surface Glycoprotein CD3 Epsilon Chain Gene|T3E|TCRE	The CD3E gene at 11q23 encodes CD3E Antigen, Epsilon Polypeptide (Tit3 Complex). The TCR/CD3 complex of T lymphocytes consists of either a TCR Alpha/Beta or TCR Gamma/Delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled Gamma, Delta, Epsilon, Zeta, and Eta. The CD3 complex mediates signal transduction and recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. The CD3E gene consists of 9 exons, three of which encode the junction of the leader peptide and the mature protein. (From LocusLink, Swiss-Prot and NCI)
C24278	CD47_Gene	Cell_Adhesion_Molecule_Gene	CD47 Gene|Antigenic Surface Determinant Protein OA3 Gene|CD47|CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer) Gene|CD47 Glycoprotein Gene|IAP Gene|Integrin Associated Protein Gene|Integrin-Associated Protein Gene|Leukocyte Surface Antigen CD47 Gene|MER6 Gene|OA3 Gene|Surface Antigen Identified by Monoclonal Antibody 1D8 Gene	The CD47 gene at 3q13.1-q13.2 encodes CD47 Antigen, which is a 50-kD membrane protein with an amino-terminal immunoglobulin domain and a carboxyl-terminal multiple-membrane-spanning region. CD47 Antigen is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is also involved in membrane permeability changes induced following virus infection. Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior. The interaction of CD47 with SHPS-1 may contribute to the recruitment of B lymphocytes via endothelial cells under steady state conditions. CD47 Antigen is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. Four isoforms are produced by alternative splicing. (From LocusLink, OMIM, Swiss-Prot and NCI)
C24279	CD97_Gene	Cell_Adhesion_Molecule_Gene	CD97 Gene|CD97	The CD97 gene at 19p13 encodes CD97 Antigen, which is a founding member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules. CD97 Antigen is a glycoprotein present on the surface of most activated leukocytes and is a G protein-coupled receptor. This protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing generates two variants. CD97 Antigen has large N-terminal domain with five epidermal growth factor-like sequences which are differentially spliced. (From LocusLink and NCI)
C24280	CDC2L1_Gene	Cell_Cycle_Gene	CDC2L1 Gene|CDC2L1|CLK-1|Cell Division Cycle 2-Like 1 Gene|PK58|p58|p58CDC2L1|p58CLK-1	The CDC2L1 gene at 1p36 encodes Cell Division Cycle 2-Like 1, which is a member of the p34Cdc2 serine/threonine protein kinase family. CDC2L1 is expressed ubiquitously and acts as a negative regulator of the normal cell cycle progression. It may function in regulating proliferation by phosphorylation and subsequent plasma membrane targeting of galactosyltransferase. This gene is deleted or altered frequently in neuroblastoma with amplified MYCN genes. CDC2L1 can be cleaved by caspases and play roles in cell apoptosis. A large number of the alternatively spliced variants of this gene exist. (From LocusLink, Swiss-Prot and NCI)
C24281	CDC37_Gene	Chaperone_Gene	CDC37 Gene|CDC37|CDC37 Cell Division Cycle 37 Homolog (S. cerevisiae) Gene|CDC37 Homolog Gene|Hsp90 Chaperone Protein Kinase-Targeting Subunit Gene|Hsp90 Co-Chaperone Cdc37 Gene|P50CDC37 Gene	The CDC37 gene at 19p13.2 encodes CDC37 Homolog, a protein highly similar to Cdc 37, which is a cell division cycle control protein of Saccharomyces cerevisiae. CDC37 Homolog is a molecular chaperone with specific function in cell signal transduction. It forms complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It plays a critical role in directing the chaperone HSP90 and targeting it to the CDK4 protein kinase, thereby promoting stability of CDK4. has a role in regulating cell division cycle. (From LocusLink and NCI)
C24282	CDC42_Gene	Cell_Cycle_Gene	CDC42 Gene|CDC42|CDC42Hs|Cell Division Cycle 42 Gene|G25K|GP	The CDC42 gene at 1p36.1 encodes Cell Division Cycle 42, a small GTPase of the Rho-subfamily. This protein regulates signaling pathways that control diverse cellular functions, including cell morphology, migration, endocytosis and cell cycle progression, and the induction of malignant transformation. ACK1 is a binding partner and inhibitor of the GTP-bound form of CDC42. Interaction between GTP-CDC42 and ACK1 inhibits both the intrinsic and GAP-stimulated GTPase activity of CDC42. The product of oncogene Dbl specifically catalyzes the dissociation of GDP from CDC42. This protein regulates actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of the CDC42 gene results in the placental and brain isoforms. (From LocusLink, OMIM and NCI)
C24283	CDK10_Gene	Cyclin-Dependent_Kinase_Gene	CDK10 Gene|CDK10|Cyclin-Dependent Kinase (CDC2-like) 10 Gene|PISSLRE	The CDK10 gene at 16q24 encodes Cyclin-Dependent Kinase 10, a protein that belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members bind to cyclin to form active holoenzymes that play a pivotal role in the regulation of the eukaryotic cell cycle and are known to be essential for cell cycle progression. This kinase has been shown to play roles in cellular proliferation and its function is limited to cell cycle G2-M phase. A variety of different transcripts exist, resulting from cryptic splice sites, exon skipping, insertion of intronic sequences, and exon scrambling. The splicing of this gene is complex. At least three alternatively spliced variants of this gene exist, one of which contains multiple non-ATG translation initiation sites. (From LocusLink, OMIM and NCI)
C24284	CDK2_Gene	Cyclin-Dependent_Kinase_Gene	CDK2 Gene|CDC2-Related Protein Kinase Gene|CDK2|Cell Division Kinase 2 Gene|Cell Division Protein Kinase 2 Gene|Cyclin-Dependent Kinase 2 Isoform 1 Gene|Cyclin-Dependent Kinase 2 Isoform 2 Gene|p33 Protein Kinase Gene|p33(CDK2) Gene	The CDK2 gene at 12q13 encodes Cyclin-Dependent Kinase 2, a protein that belongs to the CDKX subfamily of the Ser/Thr protein kinase family. This protein kinase is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. It is involved in promoting DNA synthesis and cell cycle progression. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene exist. Its N-terminal domain interacts with cyclins and C-terminal domain interacts with CSK1. (From LocusLink, OMIM and NCI)
C24285	CDK2AP1_Gene	Cyclin-Dependent_Kinase_Inhibitor_Gene	CDK2AP1 Gene|CDK2-Associated Protein 1 Gene|CDK2AP1|CDKAP1|Cyclin-Dependent Kinase 2-Associated Protein 1 Gene|DOC-1|DOC1|Deleted In Oral Cancer-1 Gene|Deleted in Oral Cancer 1 Gene|p12DOC-1	The CDK2AP1 gene at 12q24.31 encodes CDK2-Associated Protein 1, a specific CDK2-associated protein that negatively regulates CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein also interacts with DNA polymerase alpha/primase and promotes the phosphorylation of the large p180 subunit, which suggests the regulatory role in DNA replication during S phase of the cell cycle. Reduction of CDK2AP1 protein expression is a frequent event in oral cancers and is a negative prognostic indicator in patients with surgically resected oral squamous cell carcinoma. Loss of CDK2AP1 protein expression may contribute to the multistep nature of oral carcinogenesis. (From LocusLink, PubMed and NCI)
C24286	CDK3_Gene	Cyclin-Dependent_Kinase_Gene	CDK3 Gene|CDK3|Cell Division Protein Kinase 3 Gene|Cyclin-Dependent Kinase 3 Gene|Cyclin-Dependent Protein Kinase 3 Gene	The CDK3 gene at 17q22-qter encodes Cyclin-Dependent Kinase 3 (CDK3), which belongs to the SER/THR family of protein kinases. CDK3 can phosphorylate histone H1 and is involved in the control of the cell cycle. CDK3 participates in the G1-S transition at least primarily by binding to E2F-1, E2F-2, or E2F-3 through DP-1 and by enhancing their transcriptional activities. CDK3 also interacts with cyclin E and cyclin A and Ik3-1/Cables is a novel substrate for CDK3-mediated phosphorylation by CDK3/cyclin E and CDK3/cyclin A. (From LocusLink, PubMed and NCI)
C24287	CDKL2_Gene	Serine-Threonine_Protein_Kinase_Gene	CDKL2 Gene|CDC2-Related Kinase Gene|CDKL2|Cyclin-Dependent Kinase-Like 2 (CDC2-Related Kinase) Gene|Cyclin-Dependent Kinase-Like 2 Gene|KKIAMRE Gene|P56 Gene|Serine/Threonine Protein Kinase KKIAMRE Gene|p56 KKIAMRE Protein Kinase Gene	The CDKL2 gene at 4q21.1 encodes Cyclin-Dependent Kinase-Like 2, which is a member of a large family of CDC2-related serine/threonine protein kinases. CDKL2 is expressed as 2 major transcripts in adult testis and kidney, and at lower levels in adult brain and lung. A single transcript is detected in fetal brain and, at very low levels, in fetal kidney. This protein accumulates primarily in the cytoplasm, with a lower level in the nucleus. Treatment of cultured cells with epidermal growth factor causes an increase in the CDKL2 activity, but this does not require phosphorylation of the conserved MAP kinase dual phosphorylation motif present in this kinase. (From LocusLink, OMIM and NCI)
C24288	CDKN2C_Gene	Cyclin-Dependent_Kinase_Inhibitor_Gene	CDKN2C Gene|CDK6 Inhibitor p18 Gene|CDKN2C|CDKN6 Gene|Cyclin-Dependent Inhibitor Gene|Cyclin-Dependent Kinase 4 Inhibitor C Gene|Cyclin-Dependent Kinase 6 Inhibitor Gene|Cyclin-Dependent Kinase 6 Inhibitor p18 Gene|Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4) Gene|Cyclin-Dependent Kinase Inhibitor 2C Gene|INK4C Gene|p18 Gene|p18(INK4C) Gene|p18-INK4C Gene|p18-INK6 Gene	The CDKN2C gene at 1p32 encodes Cyclin-Dependent Kinase Inhibitor 2C, which is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with monomeric CDK4 or CDK6, and prevent the activation of the CDK kinases, thus control cell cycle G1 progression. It inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein Rb. Two alternatively spliced transcript variants of this gene encode an identical protein. This protein contains 4 ANK repeats and is found in pancreas and heart, with the highest levels in skeletal muscle. Inactivation of CDKN2C by point mutations may contribute to deregulated growth control in certain cell lines and/or tumors. (From LocusLink, Swiss-Prot and NCI)
C24289	CDKN3_Gene	Cyclin-Dependent_Kinase_Inhibitor_Gene	CDKN3 Gene|CDI1 Gene|CDK2-Associated Dual Specificity Phosphatase Gene|CDKN3|CIP2 Gene|Cyclin-Dependent Kinase Inhibitor 3 (CDK2-Associated Dual Specificity Phosphatase) Gene|Cyclin-Dependent Kinase Inhibitor 3 Gene|Cyclin-Dependent Kinase Interacting Protein 2 Gene|Cyclin-Dependent Kinase Interactor 1 Gene|KAP Gene|KAP1 Gene|Kinase-Associated Phosphatase Gene	The CDKN3 gene at 14q22 encodes Cyclin-Dependent Kinase Inhibitor 3, which is a dual-specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. This protein is a cyclin-dependent kinase inhibitor and may play a role in cell cycle regulation. It has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. Delay of cell cycle progression is dependent on CDKN3 phosphatase activity. This protein also interacts with other cyclin-dependent kinases such as CDC2 and CDK3, but not with CDK4. The CDKN3 gene is deleted, mutated, or overexpressed in several kinds of cancers. Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC). (From LocusLink, Swiss-Prot, OMIM and NCI)
C24290	CDON_Gene	Immunoglobulin_Family_Gene	CDON Gene|CDO Gene|CDON|Cell Adhesion Molecule-Related/Down-Regulated by Oncogenes Gene|ORCAM Gene|Surface Glycoprotein, Ig Superfamily Member Gene	The human CDON gene encodes Surface Glycoprotein, Ig Superfamily Member, which is a cell surface glycoprotein and a member of the immunoglobulin superfamily. Rhabdomyosarcoma is a childhood tumor of the skeletal muscle lineage in which cells display defects in both biochemical and morphological aspects of differentiation. The immunoglobulin superfamily members CDO and BOC are components of a cell surface receptor that positively regulates myogenesis in vitro. CDO and BOC may play a role in the inverse relationship between differentiation and transformation of cells in the skeletal muscle lineage. (From PubMed 12720294, LocusLink and NCI)
C24291	CDR1_Gene	Gene_with_Unknown_or_Unclassified_Function	CDR1 Gene|CDR|CDR Gene|CDR1|CDR34|CDR34 Gene|CDR62A|CDR62A Gene|Cerebellar Degeneration-Related Autoantigen 1 Gene|Cerebellar Degeneration-Related Protein (34kD) Gene|Cerebellar Degeneration-Related Protein-1 (34kD) Gene|Cerebellar-Degeneration-Related Antigen 1 Gene	The human CDR1 gene at Xq27.1-q27.2 encodes Cerebellar-Degeneration-Related Antigen 1, which is one of the target molecules recognized by autoantibodies directed against neuronal proteins in patients with paraneoplastic cerebellar degeneration, which occurs in association with small cell carcinoma of the lung, neoplasms of the breast and ovary, and Hodgkin disease. This protein contains tandem hexapeptide repeats and is expressed in brain, predominantly in normal neuroectodermal tissues and in certain malignant tumors. (From LocusLink, Swiss-Prot and NCI)
C24292	CDX2_Gene	Homeobox_Gene	CDX2 Gene|CDX-3 Gene|CDX2|CDX3 Gene|Caudal-Type Homeo Box Transcription Factor 2 Gene|Caudal-Type Homeo Box Transcription Factor 3 Gene|Caudal-Type Homeobox Protein 2 Gene|Homeobox Protein CDX-2 Gene|Insulin-Regulating Transcription Factor CDX3 Gene	The human CDX2 gene at 13q12.3 encodes Caudal Type Homeo Box Transcription Factor 2, which is a homeodomain protein. This nuclear protein is involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. It is important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Phosphorylation of Ser-60 of this protein mediates the transactivation capacity. CDX3 binds an A/T-rich sequence in the insulin promoter and stimulate its transcription. Increased CDX2 mRNA is associated with chronic atrophic gastritis and expression of CDX2 may trigger the initiation and development of intestinal metaplasia. In contrast, markedly reduced or absent CDX2 expression is noted in most large cell minimally differentiated carcinomas. (From LocusLink, Swiss-Prot, OMIM and NCI)
C24293	CEACAM7_Gene	CEA_Family_Gene	CEACAM7 Gene|CEACAM7|CGM2|Carcinoembryonic Antigen Gene Family Member 2|Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7 Gene	The human CEACAM7 gene at 19q13.2 encodes Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7, which belongs to the carcinoembryonic antigen (CEA) family in the immunoglobulin superfamily. It contains one immunoglobulin-like V-type domain and one immunoglobulin-like C2-type domain. This protein is a potential tumor suppressor protein and strongly down-regulated in colon adenocarcinomas. Two isoforms (2a and 2b) of this protein are produced by alternative splicing. (From LocusLink, Swiss-Prot and NCI)
C24294	CELSR1_Gene	G_Protein-Coupled_Receptor_Gene	CELSR1 Gene|CDHF9|CELSR1|Cadherin, EGF LAG Seven-Pass G-Type Receptor 1 (Flamingo Homolog, Drosophila) Gene|FMI2|HFMI2|ME2	The human CELSR1 gene at 22q13.3 encodes Cadherin EGF LAG Seven-Pass G-Type Receptor 1, which is a G-Protein Coupled Receptor that may have an important role in cell/cell signaling during nervous system formation. It is an integral membrane protein with seven transmembrane domains, multiple cadherin repeats, EGF-like repeats, and laminin A G-type repeats. Two isoforms (1 and 2) may be produced by alternative splicing. The CELSR1 gene is developmentally regulated and neural-specific and the protein plays an unspecified role in early embryogenesis. (From LocusLink, Swiss-Prot, PubMed and NCI)
C24295	CHEK1_Gene	Serine-Threonine_Protein_Kinase_Gene	CHEK1 Gene|CHEK1|CHK1 Checkpoint Homolog (S.Pombe) Gene|CHK1 Gene|Cell Cycle Checkpoint Kinase Gene|Serine/Threonine-Protein Kinase CHK1 Gene	The human CHEK1 gene at 11q24-q24 encodes CHK1 Checkpoint Homolog, which is a serine/threonine protein kinase that is required for the DNA damage checkpoint. This protein is involved in cell cycle arrest when DNA damage has occurred or when unligated DNA is present. It binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25C on serine-216 creates a binding site for 14-3-3 protein which inhibits CDC25C. This prevents activation of the CDC2-Cyclin B complex and prevents mitotic entry. This protein is expressed ubiquitously with the most abundant expression in thymus, testis, small intestine, and colon. (From LocusLink, Swiss-Prot, PubMed and NCI)
C24296	CHK_Gene	Kinase_Family_Gene	CHKA Gene|CHETK-Alpha Gene|CHK|CHKA|CHOK|CK|CKI|Choline Kinase Alpha Gene|Choline Kinase Gene	The human CHK gene at 11q13.1 encodes Choline Kinase, which produces phosphocholine from choline. The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. Choline kinase is the initial enzyme in the sequence and may play a regulatory role. Choline kinase also catalyzes the phosphorylation of ethanolamine. (From LocusLink and NCI)
C24297	CHRM4_Gene	G_Protein-Coupled_Receptor_Gene	CHRM4 Gene|Acetylcholine Receptor, Muscarinic, 4 Gene|CHRM4|Cholinergic Receptor, Muscarinic, 4 Gene|HM4 Gene|Muscarinic Acetylcholine Receptor M4 Gene	The human CHRM4 gene at 11p12-p11.2 encodes Cholinergic Receptor, Muscarinic 4, which is a G protein-coupled receptor. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and postassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. (From LocusLink and NCI)
C24298	CHS1_Gene	Trafficking_Protein_Gene	LYST Gene|CHS|CHS1|CHS1 Gene|Chediak-Higashi Syndrome 1 Gene|LYST|Lysosomal Trafficking Regulator Gene	The human CHS1 gene at 1q42.1-q42.2 encodes Chediak-Higashi Syndrome 1, which is Lysosomal-Trafficking Regulator Protein. This 425-kD cytoplasmic protein may sort endosomal resident proteins into late multivesicular endosome by a mechanism involving microtubules. It contains 7 WD repeats (TRP-ASP domains) and 1 beach domain, and is abundantly expressed in adult and fetal thymus, peripheral blood leukocytes, bone marrow and several regions of the adult brain. At least 3 isoforms (1, 2, 3) are produced by alternative splicing. Defects in the CHS1 gene are the cause of Chediak-Higashi Syndrome (CHS), an inherited immunodeficiency disease characterized by giant lysosomes and impaired leukocyte degranulation. (From LocusLink, Swiss-Prot, PubMed and NCI)
C24299	CISH_Gene	Suppressor_of_Cytokine_Signaling_Family_Gene	CISH Gene|CIS Gene|CIS-1 Gene|CISH|Cytokine-Inducible Inhibitor of Signaling Type 1B Gene|Cytokine-Inducible SH2-Containing Protein Gene|G18 Gene|SOCS Gene|Suppressor of Cytokine Signaling Gene	The human CISH gene at 3p21.3 encodes Cytokine Inducible SH2-Containing Protein, which is a cytokine-inducible negative regulator of cytokine signaling. This protein contains a SH2 domain and a SOCS box domain. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein is involved in the inactivation of the erythropoietin receptor. Association with EPOR may target this protein for proteolysis by the ubiquitin-dependent proteasome pathway. The CISH protein is mainly monoubiquitinated (37 kD) but may also exist in a polyubiquitinated form (45 kD). Three isoforms (1, 1B, 1C) are produced by alternative splicing, and the tissue distribution of isoforms 1 and 1B is distinct. CISH deletion may be involved in the pathogenesis of renal cell carcinomas and of lung cancer since lung and kidney tumors frequently exhibit 3p21.3 deletions. (From LocusLink, Swiss-Prot and NCI)
C24300	CLC_Gene	Interleukin_Gene	CLC Gene|BSF3|CLC	The human CLC gene at 11q13.3 encodes Cardiotrophin-Like Cytokine, which is a cytokine of the IL-6 family. This protein stimulates nerve cell survival and B-cell proliferation. (From LocusLink and NCI)
C24301	CMKLR1_Gene	G_Protein-Coupled_Receptor_Gene	CMKLR1 Gene|CMKLR1|Chemokine-Like Receptor 1 Gene	The human CMKLR1 gene at 12q24.1 encodes Chemokine-Like Receptor 1, which is an orphan receptor that belongs to G Protein-Coupled Receptor. This protein may be a chemotactic peptide receptor. It is expressed during bone development and may have a function in bone metabolism. It is prominently expressed in developing osseous and cartilaginous tissue. It is also found in adult parathyroid glands. It also acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Two isoforms (A, B) are produced by alternative splicing. (From Swiss-Prot and NCI)
C24302	CNK_Gene	Serine-Threonine_Protein_Kinase_Gene	PLK3 Gene|CNK|Cytokine-Inducible Kinase Gene|PLK3|Polo-Like Kinase 3 (Drosophila) Gene	The human CNK gene at 1p34.1 encodes Cytokine-Inducible Kinase, which is a serine/threonine protein kinase that is involved in regulating M phase functions during the cell cycle. This membrane-associated protein may play a role in regulation of cell cycle progression and tumorigenesis. It may also be part of the signaling network controlling cellular adhesion. It is phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis. Cytokine and cellular adhesion trigger CNK induction. CNK contains both a catalytic domain and a putative regulatory domain. It binds to the calcium/integrin-binding protein (CIB) and this interaction probably occurs via the polo-box domain. Transcripts expression appears to be down-regulated in primary lung tumor. (From LocusLink, Swiss-Prot and NCI)
C24303	CNK1_Gene	Gene_with_Unknown_or_Unclassified_Function	CNKSR1 Gene|CNK|CNK1|CNKSR1|Connector Enhancer of Kinase Suppressor of Ras 1 Gene|KSR	The human CNK1 gene at 1p36.11 encodes Connector Enhancer of KSR-Like (Drosophila Kinase Suppressor of Ras). Drosophila CNK is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. Drosophila CNK interacts with RAF and localizes to cell junctions, required by several pathways stimulated by receptor tyrosine kinases. The function of human CNK1 remains unknown. (From OMIM and NCI)
C24304	CNTNAP1_Gene	Receptor_Gene	CNTNAP1 Gene|CASPR|CNTNAP|CNTNAP1|Contactin Associated Protein 1 Gene|NRXN4|Neurexin 4 Gene|Neurexin IV Gene|P190	Encodes a novel contactin-associated transmembrane receptor (p190/Caspr) containing a mosaic of domains implicated in protein-protein interactions. The protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. (from EMBO J 1997;16:978-88)
C24305	COL18A1_Gene	Collagen_Gene	COL18A1 Gene|COL18A1|Collagen XVIII (Alpha 1) Gene|Collagen, Type XVIII, Alpha 1 Gene	The human COL18A1 gene at 21q22.3 encodes Collagen XVIII (Alpha 1), which is the alpha chain of type XVIII collagen. This collagen is one of the multiplexins, extracellular matrix proteins that contain multiple triple-helix domains (collagenous domains) interrupted by non-collagenous domains. Mutations in this gene are associated with Knobloch syndrome. The main features of this syndrome involve retinal abnormalities so type XVIII collagen may play an important role in retinal structure and in neural tube closure. Three transcripts have been identified for this gene as a result of alternate promoter utilization and alternative splicing. A long variant predominates in liver, while a short variant is present in conventional basement membranes. The proteolytically produced C-terminal fragment of Collagen XVIII (Alpha 1) is endostatin, a potent antiangiogenic protein. (From LocusLink and NCI)
C24306	COL4A3_Gene	Collagen_Gene	COL4A3 Gene|Alpha 3 Type IV Collagen Precursor Gene|COL4A3|COL4A3BP Gene|Collagen IV, Alpha-3 Polypeptide Gene|Collagen Type IV Alpha 3 Binding Protein Gene|Collagen of Basement Membrane, Alpha-3 Chain Gene|Collagen, Type IV, Alpha 3 (Goodpasture Antigen) Gene|GPBP Gene|Goodpasture Antigen Gene|Goodpasture Antigen-Binding Protein Gene|STAR-Related Lipid Transfer Protein 11 Gene|STARD11 Gene|START Domain-Containing Protein 11 Gene|TUMSTATIN Gene	The human COL4A3 gene at 2q36-q37 encodes Collagen IV (Alpha 3), a subunit of type IV collagen, the major structural component of basement membranes. In Goodpasture syndrome, autoantibodies bind to collagen in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized to the non-collagenous C-terminal domain of this protein. There are 6 alternate transcripts unique to this gene and alternate splicing is restricted to the 6 exons encoding this domain. This protein is widely expressed. Two protein isoforms (1 and 2/Delta26/GPBPD26) are produced by alternative splicing. This gene is also linked to the autosomal recessive Alport syndrome. The mutations contributing to this syndrome are also located within the exons encoding this C-terminal region. This protein phosphorylates the Goodpasture autoantigen in vitro on Ser and Thr residues. Isoform 2 seems less active. (From LocusLink, Swiss-Prot and NCI)
C24307	COL4A6_Gene	Collagen_Gene	COL4A6 Gene|COL4A6|Collagen IV (Alpha 6) Gene|Collagen, Type IV, Alpha 6 Gene	The human COL4A6 gene at Xq22 encodes Collagen IV (Alpha 6), a subunit of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene. (From LocusLink and NCI)
C24308	COX6C_Gene	Protein_Complex_Subunit_Gene	COX6C Gene|COX6C|Cytochrome C Oxidase Subunit VIC Gene	The human COX6C gene at 8q22-q23 encodes Cytochrome C Oxidase Subunit Vic. Cytochrome C Oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The nuclear-encoded subunits may be involved in the regulation and assembly of the complex. The COX VIc subunit is found in all mammalian tissues. This mitochondrial protein does not have a presequence that targets mitochondria and the mature form itself has the property of a presequence. A pseudogene COX6CP1 has been found on chromosomes 16p12. (From LocusLink and NCI)
C24309	CPNE7_Gene	Membrane_Protein_Gene	CPNE7 Gene|CPNE7|Copine 7 Gene|Copine VII Gene|MGC34192 Gene	The human CPNE7 gene at 16q24.3 encodes Copine VII, which is a calcium-dependent membrane-binding protein. Molecular events at the interface of the cell membrane and cytoplasm may be regulated by proteins that attach to and detach from the membrane surface in response to signals. Calcium-dependent membrane-binding proteins may play such a role. Copine VII contains two N-terminal C2 domains and one von Willebrand factor A domain. It may function in membrane trafficking. Two isoforms (1 and 2) may be produced by alternative splicing. This gene has been excluded as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3. (NCI)
C24310	CSF2_Gene	Colony-Stimulating_Factor_Gene	CSF2 Gene|CSF2|Colony Stimulating Factor 2 (Granulocyte-Macrophage) Gene|GMCSF	The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. (from LocusLink)
C24311	CSF2RB_Gene	Cytokine_Receptor_Gene	CSF2RB Gene|CDw131|CSF2RB|IL3RB|IL5RB	The CSF2RB gene encodes Colony Stimulating Factor 2 Receptor, Beta, Low-Affinity (CSF2RB), which is a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defective CSF2RB has been reported to be associated with protein alveolar proteinosis. (From LocusLink)
C24312	CSF3_Gene	Colony-Stimulating_Factor_Gene	CSF3 Gene|CSF3|Colony Stimulating Factor 3 (Granulocyte) Gene|G-CSF|GCSF|MGC45931	The CSF3 gene encodes Colony Stimulating Factor 3, which is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Three transcript variants encoding three different isoforms have been found for this gene. (From LocusLink)
C24313	CSF3R_Gene	Cytokine_Receptor_Gene	CSF3R Gene|CD114|CSF3R|Colony Stimulating Factor 3 Receptor (Granulocyte) Gene|GCSFR	The CSF3 gene encodes Colony Stimulating Factor 3, which is a cytokine that controls the production, differentiation, and function of granulocytes. Colony Stimulating Factor 3, a member of the family of cytokine receptors, may also function in some cell surface adhesion or recognition processes. Four transcript variants encoding four different isoforms have been found for this gene, with three of the isoforms being membrane-bound and the other being secreted and soluble. Mutations in this gene are a cause of Kostmann syndrome, also known as severe congenital neutropenia. (from LocusLink)
C24314	CSNK1A1_Gene	Serine-Threonine_Protein_Kinase_Gene	CSNK1A1 Gene|CK1|CSNK1A1|Casein Kinase 1, Alpha 1 Gene|HLCDGP1|PRO2975	The human CSNK1A1 gene at 5q32 encodes Casein Kinase 1, Alpha 1, which is a serine/threonine protein kinase and has broad specificity. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. This cytoplasmic protein can phosphorylate a large number of proteins. (From LocusLink, Swiss-Prot and NCI)
C24315	CSNK2A1_Gene	Serine-Threonine_Protein_Kinase_Gene	CSNK2A1 Gene|CK2A1|CKII|CSNK2A1|Casein Kinase 2, Alpha Prime Polypeptide Gene	The CSNK2A1 gene encodes Casein Kinase 2, Alpha 1 Polypeptide. Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. This kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. While this gene is found on chromosome 20, a related transcribed pseudogene is found on chromosome 11. Three transcript variants encoding two different isoforms have been found for this gene. (From LocusLink)
C24316	CSPG4_Gene	Structural_Gene	CSPG4 Gene|CSPG4|Chondroitin Sulfate Proteoglycan 4 (Melanoma-Associated) Gene|MCSP|MCSPG|MEL-CSPG|MSK16|NG2	A human melanoma-associated chondroitin sulfate proteoglycan plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. (LocusLink)
C24317	CSPG6_Gene	Structural_Gene	CSPG6 Gene|BAM|BMH|CSPG6|Chondroitin Sulfate Proteoglycan 6 (Bamacan) Gene|HCAP|SMC3|SMC3L1	Chondroitin Sulfate Proteoglycan 6 (CSPG6), encoded by the CSPG6 gene, is an abundant secreted chondroitin sulfate proteoglycan in basement membranes and an intracellular protein. CSPG6 is involved in chromosome cohesion during cell cycle and in DNA repair as a central component of the cohesin complex, which is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis and in chromosome movement. (from LocusLink)
C24318	CTBP2_Gene	Transcription_Corepressor_Gene	CTBP2 Gene|C-Terminal Binding Protein 2 Gene|CTBP2	The CTBP2 gene produces two transcripts encoding two distinct proteins. One protein is C-Terminal Binding Protein 2, which is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. (from LocusLink)
C24319	CTF1_Gene	Cytokine_Gene	CTF1 Gene|CT-1|CT1|CTF1|Cardiotrophin 1 Gene	Cardiotrophin 1 was cloned via its ability to potently induce cardiac myocyte hypertrophy in vitro.  It is a member of the family of cytokines that includes leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), and interleukin 6 (IL6). Several members of this family that are known to signal through the transmembrane protein gp130 stimulate cardiac myocyte hypertrophy, like cardiotrophin 1, suggesting that the gp130 signaling pathway may play a role in cardiac hypertrophy. (from OMIM)
C24320	CTSZ_Gene	Cysteine_Protease_Gene	CTSZ Gene|CTSX|CTSZ|Cathepsin Z Gene	The CTSZ Gene at 20q13 encodes Cathepsin Z, which is a lysosomal cysteine proteinase. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. At least two transcript variants of this gene have been found, but the full-length nature of only one of them has been determined. (From LocusLink and NCI)
C24321	CUL1_Gene	Cullin_Family_Gene	CUL1 Gene|CUL1|Cullin 1 Gene	The CUL1 gene encodes Cullin 1, an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, Cullin 1 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. It may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. (from Swiss-Prot)
C24322	CUL2_Gene	Cullin_Family_Gene	CUL2 Gene|CUL2|Cullin 2 Gene	Human CUL2 Gene (Cullin Family) encodes 745-aa 87-kDa Cullin 2, a component of multisubunit E3 ubiquitin ligase complexes with elongin BC complexes and other factors. Involved in the third step of ubiquitin conjugation, CUL2 may act as scaffold that positions substrate and the ubiquitin-conjugating enzyme. CUL2 interacts with RBX1, RNF7, and TIP120A/CAND1. (NCI)
C24323	CUL3_Gene	Cullin_Family_Gene	CUL3 Gene|CUL3|Cullin 3 Gene|KIAA0617	Widely expressed human CUL3 Gene (Cullin Family) encodes 768-aa 89-kDa neddylated nuclear and Golgi-associated Cullin 3, involved in ubiquitination of cyclin E and perhaps cyclin D1 in regulation of G1/S transition. CUL3 interacts with RBX1, RNF7, CYCE and TIP120A/CAND1. (NCI)
C24324	CUL4A_Gene	Cullin_Family_Gene	CUL4A Gene|CUL4A|Cullin 4A Gene	Human CUL4a Gene (Cullin Family) encodes 659-aa 77-kDa neddylated Cullin 4, involved in the third step of ubiquitin conjugation and proteasomal degradation of target proteins. CUL4a interacts with RBX1, RNF7 and TIP120A/CAND1. (NCI)
C24325	CUL5_Gene	Cullin_Family_Gene	CUL5 Gene|CUL5|Cullin 5 Gene|VACM-1|VACM1	Human CUL5 Gene (Cullin Family) encodes 780-aa 91-kDa neddylated Cullin 5, a component of E3 ubiquitin ligase complexes with elongin BC complex and diverse other factors, involved in the third step of ubiquitin conjugation and proteasomal degradation of target proteins. CUL5 interacts with RBX1 and RNF7. Evidence suggests that CUL5 may also form a cell surface vasopressin receptor. (NCI)
C24326	CX3CR1_Gene	Chemokine_Receptor_Gene	CX3CR1 Gene|CMKBRL1|CMKDR1|Chemokine (C-X3-C Motif) Receptor 1 Gene|GPR13|GPRV28|V28	Up-regulated by chronic inflammation and expressed in brain, peripheral blood leukocytes, and spleen, the intronless 16.5-kb human CX3CR1 Gene (CCR Family, Rhodopsin Family) at 3p21.3 produces a 3.2-kb transcript that encodes a seven transmembrane high-affinity Fractalkine Receptor, a regulator of leukocyte endothelial trafficking: chemotaxis, cell migration, and adhesion. CX3CR1 signals through a pertussis toxin sensitive G-protein to induce migration and contains common GPCR features. Tyrosine sulfation enhances fractalkine-induced cell adhesion. Sharing the CX3C motif, RSV G glycoprotein can use CX3CR1 as a receptor. CX3CR1 may be an HIV envelope protein co-receptor with CD4. Homozygous CX3CR1 I249/M280 haplotype enhances infection and progression to AIDS. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24327	CXCR4_Gene	Chemokine_Receptor_Gene	CXCR4 Gene|CXC-R4|CXCR-4|CXCR4|Chemokine (C-X-C Motif) Receptor 4 Gene|D2S201E|FB22|HM89|HSY3RR|LAP3|LCR1|LESTR|NPY3R|NPYR|NPYRL|NPYY3R	Widely expressed 3.8-kb human CXCR4 Gene (GPCR1 Family) at 2q21 encodes SDF1/PBSF Receptor CXCR4 in a 1.7-kb transcript and contains two exons (0.1- and 1.6-kb) separated by a 2-kb intron between codons 5 and 6; transcript isoform 1 is predominant. The promoter likely includes a TATA box, a NRF1 site, and two GC boxes. Sulfated 352-amino acid 39.7-kD integral membrane CXCR4 Protein is a primary GPCR for CXC chemokine SDF1/PBSF that contains a 7-transmembrane region and putative glycosylation and phosphorylation sites. Responsible for B-cell lymphopoiesis, myelopoiesis, cardiogenesis, and GI vascularization, CXCR4 may regulate CNS development. It mediates leukocyte and hematopoietic cell migration and is a primary receptor for some HIV-2 viruses, as well as a CD4 co-receptor for some HIV-1 viruses by promoting env-mediated fusion. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24328	CYP3A4_Gene	Cytochrome_P450_Family_Gene	CYP3A4 Gene|CP33|CP34|CYP3|CYP3A|CYP3A3|CYP3A4|CYPIIIA4|Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 Gene|HLP|NF-25|P450-PCN1|P450C3|P450PCN1	Human CYP3A4 gene (cytochrome P450 family 3, subfamily A), located at 7q22.1, encodes the cytochrome P450 3A4 protein, a monooxygenase enzyme that oxidizes fatty acids, drugs and xenobiotics. Defects in this gene are associated with both epipodophyllotoxin-induced leukemogenesis and lung cancer.
C24329	DAB2_Gene	Regulatory_Gene	DAB2 Gene|DAB2|DOC-2|DOC2|Disabled Homolog 2, Mitogen-Responsive Phosphoprotein (Drosophila) Gene	The human tumor suppressor DAB2 Gene encodes Disabled Homolog 2 Protein, which is expressed in ovarian, breast, and lung epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, placenta, brainstem, heart, and small intestine. The 770-amino acid 82.5-kD predicted protein has 83% identity with mouse p96 protein, a putative mitogen-responsive phosphoprotein; strongest homology exists in the N-terminal PTB/PID domain. Potentially phosphorylated, DAB2 is a putative component of the CSF-1 cell proliferation signal transduction pathway. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24330	DAXX_Gene	Signaling_Pathway_Gene|Transcription_Corepressor_Gene	DAXX Gene|BING2|DAP6|DAXX|Death-Associated Protein 6 Gene|EAP1|hDAXX	The 4.5-kb seven-exon human DAXX Gene (DAXX Family) at 6p21.3 generates two isoforms of a ubiquitous 2.6-kb mRNA encoding a nuclear/cytoplasmic 740-amino acid 81.4-kD putative homomultimeric Death Domain-Associated Protein 6: a sumoylated, phosphorylated protein with Glu-rich, NLS, and JNK activation domains. Bound to TGFBR2 and the TNFRSF6 FAS death domain via its C-terminus, DAXX bridges apoptotic FAS activation with caspase-independent ASK1 activation of JNK. HSPB1/HSP27-DAXX may block apoptosis. As transcription co-repressor, DAXX is recruited to nucleoli or PML/POD/ND10 nuclear bodies by MCSR1 or PML. DAXX inhibits PAX3 and ETS1. As part of PAX5/CREBBP, DAXX may modulate PAX5. It binds SLC2A4/GLUT4, CENPC1, UBE2I, PAX7, DEK, HDAC1, HDAC2, HDAC3, H2A, H2B, H3, and H4. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24331	DBCCR1_Gene	Gene_with_Unknown_or_Unclassified_Function	DBC1 Gene|DBC1|DBCCR1|Deleted in Bladder Cancer 1 Gene|FAM5A	The 203-kb human tumor suppressor DBCCR1 Gene at 9q32-q33 produces a 3.2-kb mRNA that encodes a 761-amino acid 88.9-kD DBCCR1 Protein with a MAC/Perforin domain, seven potential N-glycosylation sites, four N-myristoylation sites, and thirty phosphorylation sites. The telomeric 5-prime CpG island may be a target of hypermethylation and hypermethylation-based silencing in some bladder cancers. DBCCR1 contains eight exons expressed as a single major band of 3.0-3.5 kb in many normal tissues. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24332	MAP17_Gene	Transmembrane_Protein_Gene	MAP17 Gene|DD96 Gene|MAP17|Membrane-Associated Protein 17 Gene	Mostly expressed in kidney proximal tubular epithelial cells, human MAP17 Gene encodes 114-aa Membrane Associated Protein 17 kDa, an intracellular protein associated with the cytoplasmic aspect of the apical brush border plasma membrane that interacts with PDZK1. (NCI)
C24333	DDR2_Gene	Receptor_Tyrosine_Kinase_Gene	DDR2 Gene|DDR2|Discoidin Domain Receptor Family, Member 2 Gene|NTRKR3|TKT|TYRO10	Expressed in heart, lung, brain, placenta, liver, skeletal muscle, pancreas, and kidney, the 148-kb human DDR2 Gene (InRTK Subfamily) at 1q12-q23 encodes a major 10-kb transcript that yields a 855-amino acid 96.8-kD precursor transmembrane receptor tyrosine kinase for fibrillar collagen, Discoidin Domain Receptor 2, involved in cell adhesion. Mediating fibroblast migration and proliferation, the type I membrane protein contains an intracellular catalytic domain and extracellular coagulation factor 5/8 type C and discoidin domains. RTKs often transduce signals by ligand induced receptor oligomerization, intracellular autophosphorylation, and phosphorylation of cytosolic targets. DDR2 may contribute to cutaneous wound healing. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24334	DDX1_Gene	Gene_with_Unknown_or_Unclassified_Function	DDX1 Gene|DBP-RB|DDX1|DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 1 Gene	Highly expressed in neuroectodermal tissues, the 40-kb human DDX1 Gene at 2p24 encodes a 2.4-kb mRNA that yields a 740-amino acid 82.4-kD DEAD/H Box Protein 1 of unknown function, which contains a SPRY domain and belongs to the DEAD/H box ATP-dependent RNA helicase family (member 1). DEAD box proteins, characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24335	DDX16_Gene	Regulatory_Gene	DDX16 Gene|DBP2|DDX16|DEAH (Asp-Glu-Ala-His) Box Polypeptide 16 Gene|KIAA0577|PRP8	Ubiquitously expressed 20-kb human DDX16 Gene (DEAD/H Subfamily, member 16) at 6p21.3 maps to a MHC region containing malignant, genetic, and autoimmune disease genes. A 3.4-kb mRNA encodes a 1041-amino acid 119.3-kD nuclear protein homolog of cell cycle progression protein Prp8/cdc28 (S. pombe), similar to DEAH box protein splicing factors. DEAD/H Box Protein 16 is a probable ATP-binding RNA helicase involved in pre-mRNA splicing. DEAD box proteins, characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24336	DDX26_Gene	Gene_with_Unknown_or_Unclassified_Function	DDX26 Gene|DBI-1|DDX26|DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 26 Gene|DICE1|DKFZP434B105|Deleted in Cancer 1|HDB|NOTCHL2	The 99-kb candidate tumor suppressor human DDX26 Gene (DEAD Family) at 13q14.12-q14.2 is located in a critical loss of heterozygosity region and encodes a highly conserved 1687-amino acid 188.5-kD DEAD/H Box Protein 26 containing a vWF type A domain with a likely important cellular function. A major 4.4-, and a minor 6.9-kb, transcript is expressed in a wide variety of fetal and adult tissues. DEAD box proteins, characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24337	DEC1_Gene	Gene_with_Unknown_or_Unclassified_Function	DEC1 Gene|CTS9|Deleted in Esophageal Cancer 1 Gene	The 261-kb human DEC1 Gene at 9q32 is located in a region commonly deleted in esophageal squamous cell carcinomas. A 1.4-kb transcript is widely expressed; reduced or absent in esophageal squamous cell carcinomas. DEC1 encodes a candidate tumor suppressor deduced 70-amino acid protein of unknown function; possibly negative regulation of cell proliferation. (from LocusLink, OMIM, and NCI)
C24338	DEFB1_Gene	Immunoprotein_Gene	DEFB1 Gene|BD1|DEFB-1|DEFB1|DEFB101|HBD-1|HBD1	The 7.4-kb human DEFB1 Gene (Beta-Defensin Family) at 8p23.2-p23.1 includes a 7-kb intron and maps within 150-kb of the neutrophilic Alpha-Defensin-1 gene. The 362-bp mRNA encodes a 7.4-kD Beta-Defensin 1 Protein prepropeptide, containing a 68-amino acid antimicrobial peptide secreted into plasma and implicated in cystic fibrosis pathogenesis. Multiple plasma forms are bound to carrier macromolecules. Highest DEFB1 concentrations occur in kidney and female reproductive tract epithelia. Expression is not up regulated by lipopolysaccharide; IL1B appears to stimulate DEFB2 expression, but not DEFB1. DEFB1 may act in innate immunity. Mammalian alpha- and beta-defensins comprise 3.5- to 5-kD cysteine- and arginine-rich neutrophilic microbicidal and cytotoxic peptides. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24339	DEK_Gene	Regulatory_Gene	DEK Gene|D6S231E|DEK|DEK Oncogene|DEK Oncogene (DNA Binding) Gene	The 40-kb human DEK Gene at 6p23 encodes ubiquitous 375-amino acid 43-kD nuclear RNA- and DNA-binding DEK Protein, containing a SAP domain. DEK may be involved in transcription and signal transduction. Most is associated with chromatin, a fraction with RNA. The amount and localization does not change during the cell cycle. DEK binds the HIV-2 'pets' site, interacts with histones, DAXX, and HDAC2, and induces superhelical chromatin alterations with TOP1 or TOP2A. It does not induce histone displacement, but changes nucleosomal DNA topology, and reduces replication efficiency. DEK is a spliced exon-associated spliceosome component mediated by SR protein interactions, such as SRM160. AML-associated t(6;9)(p23;q34) breakpoints in specific DEK and CAN introns fuse 5-prime DEK to 3-prime CAN with no ORF interruption. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24340	DLEC1_Gene	Gene_with_Unknown_or_Unclassified_Function	DLEC1 Gene|DLC1|DLEC1|Deleted in Lung and Esophageal Cancer 1 Gene|F56	Located between PLC-delta-1 and OSR1, human DLEC1 Gene at 3p22-p21.3 spans at least 59-kb containing 37 exons that encode numerous alternatively spliced, widely expressed 6-8-kb mRNAs (DLEC1-N, -L, -S). DLEC1-N1 and -N2 contain all 37 exons and encode a full-length 1755-amino acid 195.8-kD DLEC1 Protein, a likely negative regulator of cell proliferation. DLEC1-S1, -S2, and -S3 lack exons 11, 13, or 36 and encode frame-shifted protein. DLEC1-L1 and -L2 include all or part of intron 13 and encode prematurely truncated proteins. DLC1 expression appears to suppress growth of some cancer cell lines. Aberrant transcription may be involved in carcinogenesis of the lung, esophagus, and kidney. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24341	DLEU1_Gene	Gene_with_Unknown_or_Unclassified_Function	DLEU1 Gene|B-Cell Neoplasia-Associated Gene with Multiple Splicing|BCMS|DLEU1|Deleted in Lymphocytic Leukemia 1|Deleted in Lymphocytic Leukemia, 1 Gene|LEU1|Leukemia Associated Gene 1	The 8-kD human DLEU1 Gene at 13q14.3 lacks a TATA box, appears to have many cis-acting elements, and appears to encode a 72-amino acid putative tumor suppressor DLEU1 Protein for BCLL. Expression of a 1.1-kb transcript occurs in testis, thymus, small intestine, prostate, spleen, peripheral blood lymphocytes, and ovary. Approximately 300-bp apart, DLEU1 and DLEU2 are arranged head-to-head and transcribed in opposite directions. LEU1 is a small portion of the BCMS gene, spanning at least 560-kb and composed of 50 exons or more expressed in more than 20 tissue-specific RNA splice variants. BCMS transcripts may be noncoding RNAs.  (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24342	DLEU2_Gene	Gene_with_Unknown_or_Unclassified_Function	DLEU2 Gene|BCMSUN|DLEU2|Deleted in Lymphocytic Leukemia 2|Deleted in Lymphocytic Leukemia, 2 Gene|LEU2	The 38.6-kb human DLEU2 Gene at 13q14.3 lacks a TATA box, appears to have many cis-acting elements, and appears to encode an 84-amino acid 10-kD putative tumor suppressor DLEU2 Protein. Strong expression of 1.4- and 1.8-kb transcripts appears to occur only in thymus and testis. Approximately 300- bp apart, DLEU1 and DLEU2 are arranged head-to-head and transcribed in opposite directions. LEU2 appears to be a portion of the BCMS gene, spanning at least 560-kb and composed of 50 exons or more expressed in more than 20 tissue-specific RNA splice variants. BCMS transcripts may be noncoding RNAs.  (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24343	DLG1_Gene	Membrane-Associated_Guanylate_Kinase_Family_Gene	DLG1 Gene|DLG1|Discs, Large Homolog 1 (Drosophila) Gene|HDLG|SAP97	Human DLG1 Gene (MAGUK Family) at 3q29 encodes alternative isoforms 1 (904-aa) and 2 (926-aa) of 100-kD Presynaptic Protein SAP97, a putative kinase that appears to regulate protein targeting and contains one SH3, one Guanylate Kinase-like, and three PDZ/DHR domains. DLG1 binds to membrane cytoskeletal protein 4.1 (EPB41) and to KIF13B, and interacts with the KCNAB1 channel as well as the cytoplasmic tail of NMDA receptor subunits. LCK interacts with the proline-rich N-terminal domain of DLG1. Interacting with actin-binding ezrin, SAP97 is also involved in cell shape morphogenesis. (NCI)
C24344	DLG4_Gene	Membrane-Associated_Guanylate_Kinase_Family_Gene	DLG4 Gene|DLG4|Discs, Large Homolog 4 (Drosophila)|PSD-95|PSD95|SAP90	Widely expressed, human DLG4 Gene (MAGUK Family) at 17p13.1 encodes 767-aa 85-kD cytoplasmic Presynaptic Density Protein 95 (concentrated at presynaptic junctions), containing one SH3, one Guanylate Kinase-like, and three PDZ/DHR domains. It heteromultimerizes with DLG2, interacts with the cytoplasmic tail of NMDA receptor subunits, and, with DLG2, mediates NMDA and potassium channel clustering. PSD-95 also binds to KIF13B and interacts through a PDZ domain with NLGN1. DLG4 may form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. (NCI)
C24345	DMBT1_Gene	Receptor_Gene	DMBT1 Gene|DMBT1|DMBT1/8kD.2 Protein Gene|Deleted in Malignant Brain Tumors 1 Gene|GP340 Gene|Glycoprotein 340 Gene|Surfactant, Pulmonary-Associated Protein D-Binding Protein Gene	The human DMBT1 gene at 10q25.3-q26.1 encodes Deleted in Malignant Brain Tumors 1, which is a member of the scavenger-receptor superfamily and likely a truncated form of a receptor for SFTPD. This 340 kD protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Binding between GP340 and SFTPD is a protein-protein interaction and the binding to GP340 takes place via the carbohydrate recognition domain of SFTPD. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. Transcript variant 2 (8.0 kb) binds surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may play a role in the interaction of tumor cells and the immune system. (From LocusLink, OMIM and NCI)
C24346	DNMT3B_Gene	Methyltransferase_Gene	DNMT3B Gene|DNA (Cytosine-5-)-Methyltransferase 3 Beta Gene|DNA MTase HsaIIIB Gene|DNA Methyltransferase 3B Gene|DNA Methyltransferase HsaIIIB Gene|DNMT3B|ICF Gene|M.HsaIIIB Gene	The human DNMT3B gene at 20q11.2 encodes DNA Methyltransferase 3B, which is required for genome wide de novo methylation and is essential for development. This nuclear protein interacts with UBL1 and UBE2I9. Six isoforms (1, 2, 3, 4, 5 and 6) are produced by alternative splicing but isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate. Defects in DNMT3B are a cause of immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. ICF is biochemically characterized by hypomethylation of CpG sites in some regions of heterochromatin. (From LocusLink, Swiss-Prot and NCI)
C24347	DOC-1R_Gene	Gene_with_Unknown_or_Unclassified_Function	CDK2AP2 Gene|CDK2AP2|DOC-1R|DOC-1R Gene|Tumor Suppressor Deleted In Oral Cancer-Related 1 Gene	Human DOC-1R Gene (DOC1 Family) encodes ubiquitous 126-aa 13-kDa Tumor Suppressor Deleted In Oral Cancer-Related 1 protein. (NCI)
C24348	DOCK1_Gene	Regulatory_Gene	DOCK1 Gene|DOCK, 180-kD Gene|DOCK1|DOCK180 Gene|Dedicator of Cyto-Kinesis 1 Gene|Dedicator of Cytokinesis 1 Gene|Downstream of CRK-Binding Protein, 180-kD Gene	The human DOCK1 gene at 10q26.13-q26.3 encodes Dedicator of Cyto-Kinesis 1, which binds to the SH3 domain of CRK protein and may be involved in integrin signaling. It may regulate cell surface extension. During programmed cell death (apoptosis), cell corpses are rapidly engulfed. This engulfment process involves the recognition and subsequent phagocytosis of cell corpses by engulfing cells. This protein may function in the cell surface extension of an engulfing cell around a dying cell during apoptosis. (From LocusLink, OMIM and NCI)
C24349	DOK1_Gene	Signaling_Pathway_Gene	DOK1 Gene|DOK1|Docking Protein 1 (Downstream of Tyrosine Kinase 1) Gene|Docking Protein 1 Gene|Docking Protein 1, 62kD (Downstream of Tyrosine Kinase 1) Gene|Downstream of Trosine Knase 1 Gene|P62DOK Gene|p62(DOK) Gene|pp62 Gene	The human DOK1 gene at 2p13 encodes Docking Protein 1, which interacts with receptor tyrosine kinases and mediates particular biological responses. This 62-kD protein is associated with p120 Ras-GAP and this association is correlated with its tyrosine phosphorylation. It is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. It plays an important role in mitogenic signaling and its aberrant phosphorylation may contribute to the progression of different human diseases. It is phosphorylated by the insulin receptor kinase, resulting in the negative regulation of the insulin signaling pathway. (From LocusLink, Swiss-Prot, OMIM and NCI)
C24350	DRD1_Gene	G_Protein-Coupled_Receptor_Gene	DRD1 Gene|DRD1|Dopamine Receptor D1 Gene	The human DRD1 gene at 5q35.1 encodes Dopamine Receptor D1, which is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. It regulates neuronal growth and development, mediates some behavioral responses, and modulates dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. (From LocusLink and NCI)
C24351	DRD4_Gene	G_Protein-Coupled_Receptor_Gene	DRD4 Gene|D(2C) Dopamine Receptor Gene|D(4) Dopamine Receptor Gene|D4DR Gene|DRD4|Dopamine Receptor D4 Gene	The human DRD4 gene at 11p15.5 encodes Dopamine Receptor D4, which is a G-protein coupled receptor that inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. DRD4 is one of the most variable human genes known. Most of this diversity is the result of length and single-nucleotide polymorphism (SNP) variation in a 48-bp VNTR in exon 3, which encodes the third intracellular loop of this dopamine receptor. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. (From LocusLink, OMIM and NCI)
C24352	DRD5_Gene	G_Protein-Coupled_Receptor_Gene	DRD5 Gene|D(1B) Dopamine Receptor Gene|D(5) Dopamine Receptor Gene|D1beta Dopamine Receptor Gene|DBDR Gene|DRD1B Gene|DRD1L2 Gene|DRD5|Dopamine Receptor D1B Gene|Dopamine Receptor D5 Gene	The human DRD5 gene at 4p16.1 encodes Dopamine Receptor D5, which is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. This receptor complexes selectively with GABA-A ligand-gated channel through the direct binding of its carboxy-terminal domain with the second intracellular loop of the GABA-A gamma-2 (short) receptor subunit. This physical association enables mutual inhibitory functional interactions between these receptor systems. Pseudogenes related to this gene reside on chromosomes 1 and 2. Defects in DRD5 are a cause of blepharospasm, a primary focal dystonia affecting the orbicularis oculi muscles, usually beginning in middle age. (From LocusLink, Swiss-Prot, OMIM and NCI)
C24353	DTR_Gene	Growth_Factor_Gene	HBEGF Gene|DT-R|DTR|DTR Gene|DTS|Diphteria Toxin Receptor Gene|Diphtheria Toxin Receptor (Heparin-Binding EGF-Like Growth Factor) Gene|Diphtheria Toxin Receptor Gene|Diphtheria Toxin Sensitivity Gene|HB-EGF|HBEGF|HEGFL|Heparin-Binding EGF-Like Growth Factor Gene	The human DTR gene at 5q23 encodes Diphtheria Toxin Receptor, which is a heparin-binding EGF-like growth factor. It is mitogenic for fibroblasts and smooth muscle and may be involved in macrophage-mediated cellular proliferation. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. This mature type I membrane protein is released into the extracellular space and probably binds to a receptor. (From LocusLink, Swiss-Prot and NCI)
C24354	DTX1_Gene	Transcription_Corepressor_Gene	DTX1 Gene|DTX1|Deltex Homolog 1 (Drosophila) Gene|Deltex Homolog 1 Gene	The human DTX1 gene at 12q24.21 encodes Deltex Homolog 1, which is a transcription corepressor. Notch1 activates CSL by displacing corerepssors and recruiting coactivator. The N terminus of Deltex Homolog 1 directly interacts with the Notch1 ankyrin repeats, and specifically prevents the recruitment of coactivators and limits CSL activation below the threshold needed for induction of T cell fate. Deltex Homolog 1 may also actively promote B cell fate in common lymphoid progenitors. This protein is expressed in T lymphocytes at all stages of development. (From LocusLink, OMIM and NCI)
C24355	DUSP1_Gene	Protein_Phosphatase_Gene	DUSP1 Gene|CL100|DUSP1|Dual Specificity Phosphatase 1 Gene|HVH1|MKP-1|PTPN10|Serine/Threonine Specific Protein Phosphatase Gene	The DUSP1 gene encodes Dual Specificity Phosphatase 1, the expression of which is induced by oxidative stress and heat shock. This protein specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. (from LocusLink and Swiss-Prot)
C24356	EBAF_Gene	Transforming_Growth_Factor-Beta_Family_Gene	LEFTY2 Gene|EBAF|EBAF Gene|LEFTA|LEFTY2|LEFTYA|Left-Right Determination Factor 2 Gene|MGC46222|TGF-Beta 4 Gene|TGFB4	The human TGBF4 gene at 12q24.21 encodes TGF-Beta 4, which is a member of the TGF-beta family of proteins. This protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. It is transiently expressed before and during menstrual bleeding and may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. (From LocusLink, Swiss-Prot and NCI)
C24357	ECGF1_Gene	Glycosyltransferase_Gene	ECGF1 Gene|ECGF1|Endothelial Cell Growth Factor 1 (Platelet-Derived) Gene|hPD-ECGF	The human ECGF1 gene at 22q13.33 encodes Endothelial Cell Growth Factor 1 (Platelet-Derived), which catalyses the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. This protein may have a role in maintaining the integrity of the blood vessels. It promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell specificity acting only on endothelial cells. It also limits glial cell proliferation as gliostatin. Defects in ECGF1 are the cause of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), an autosomal recessive human disease associated with multiple deletions of skeletal muscle mitochondrial DNA (MTDNA). (From LocusLink, Swiss-Prot and NCI)
C24358	EDN2_Gene	Peptide_Hormone_Gene	EDN2 Gene|EDN2|ET2|Endothelin 2 Gene	The human EDN2 gene at 1p34 encodes Endothelin-2, a macrophage chemoattractant. Endothelins are endothelium-derived vasoconstrictor peptides. The expression of this secreted protein by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia. (From LocusLink, Swiss-Prot and NCI)
C24359	EGF_Gene	Growth_Factor_Gene	EGF Gene|EGF|Epidermal Growth Factor (Beta-Urogastrone) Gene|URG	The EGF gene encodes Epidermal Growth Factor, which has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin. The EGF precursor is believed to exist as a membrane-bound molecule that is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. (From LocusLink)
C24360	EGFL6_Gene	Gene_with_Unknown_or_Unclassified_Function	EGFL6 Gene|DKFZP564P2063|DKFZP564P2063 Gene|EGF Repeat-Containing Protein 6 Gene|EGF-Like 6|EGF-Like 6 Gene|EGFL6|Epidermal Growth Factor-Like Protein 6 Gene|MAEG|MAM Domain- and EGF Domain-Containing Gene|MAM- and EGF-Containing Gene|W80	The human EGFL6 gene at Xp22 encodes Epidermal Growth Factor-Like Protein 6, which is a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. This glycoprotein contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an Arg-Gly-Asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. (From LocusLink, Swiss-Prot and NCI)
C24361	EHF_Gene	Transcription_Factor_Gene	EHF Gene|EHF|ESE3|ESEJ|ETS Homologous Factor Gene|Epithelium-Specific ETS Factor 3 Gene	The human EHF gene at 11p12 encodes ETS Homologous Factor, which is a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). This protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. Dot blot analysis detects high levels of EHF expression in salivary gland, prostate, and trachea, with lower levels detected in colon, mammary gland, pancreas, lung, stomach, appendix, fetal kidney, and fetal lung. (From LocusLink and NCI)
C24362	EMILIN_Gene	Extracellular_Matrix_Protein_Gene	EMILIN1 Gene|DKFZP586M121|EM|EMILIN|EMILIN-1|EMILIN1|Elastin Microfibril Interface Located Gene|Elastin Microfibril Interfacer 1 Gene|gp115	The human EMILIN gene at 2p23.3-p23.2 encodes Elastin Microfibril Interface Located Protein, which is an extracellular matrix glycoprotein found between amorphous elastin and microfibrils. This protein may play a role in elastin deposition. (From LocusLink and NCI)
C24363	EPHA2_Gene	Receptor_Tyrosine_Kinase_Gene	EPHA2 Gene|ECK|EPH Receptor A2 Gene|EPHA2	This gene encodes Ephrin Receptor Epha2 that binds ephrin-A ligands. EphA2 is overexpressed in many cancers, including 40% of breast cancers.  EphA2 can also transform breast epithelial cells in vitro to display properties commonly associated with the development of metastasis. (from Microsc Res Tech 2002 Oct 1;59(1):58-67)
C24364	EPHA4_Gene	Receptor_Tyrosine_Kinase_Gene	EPHA4 Gene|EPH Receptor A4 Gene|EPHA4|HEK8|SEK|TYRO1	This gene encodes Eph-related receptor tyrosine kinase A4.  Semms to have a function in axon guiding and development of the corticospinal tract. (LocusLink and OMIM)
C24365	EPHA8_Gene	Receptor_Tyrosine_Kinase_Gene	EPHA8 Gene|EEK|EPH Receptor A8 Gene|EPHA8|HEK3|KIAA1459	The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. (LocusLink)
C24366	EPHB1_Gene	Receptor_Tyrosine_Kinase_Gene	EPHB1 Gene|ELK|EPH Receptor B1 Gene|EPHB1|EPHT2|Hek6|NET	This gene encodes Eph-related receptor tyrosine kinase B1; which may have a role in neurogenesis (Proteome Summary, from LocusLink)
C24367	EPHB2_Gene	Receptor_Tyrosine_Kinase_Gene	EPHB2 Gene|DRT|EPH Receptor B2 Gene|EPHB2|EPHT3|EPTH3|ERK|Hek5|TYRO5	This gene encodes Ephrin Receptor EphB2; which may have a role in neurogenesis (Proteome Summary, from LocusLink)
C24368	EPHB3_Gene	Receptor_Tyrosine_Kinase_Gene	EPHB3 Gene|EPH Receptor B3 Gene|EPHB3|ETK2|HEK2|TYRO6	This gene encodes Ephrin Receptor EphB3, may have a role in cell migration in the gut.
C24369	EPS15_Gene	Signaling_Pathway_Gene	EPS15 Gene|AF-1P|AF1P|ALL1 Fused Gene From Chromosome 1|EPS15|Epidermal Growth Factor Receptor Pathway Substrate 15 Gene|MLLT5	This gene encodes epidermal growth factor receptor pathway substrate 15 that plays a role in normal and neoplastic cell proliferation. (LocusLink)
C24370	EPS8_Gene	Signaling_Pathway_Gene	EPS8 Gene|EPS8|Epidermal Growth Factor Receptor Pathway Substrate 8 Gene	This gene encodes epidermal growth factor receptor pathway substrate 8 that plays a role in normal and neoplastic cell proliferation. (LocusLink)
C24371	EPS8L1_Gene	Gene_with_Unknown_or_Unclassified_Function	EPS8L1 Gene|DRC3|EPS8-Like 1 Gene|EPS8L1|EPS8R1|FLJ20258|MGC23164|MGC4642	This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Several alternatively spliced transcript variants encoding different isoforms exist. (LocusLink)
C24372	EPS8L2_Gene	Gene_with_Unknown_or_Unclassified_Function	EPS8L2 Gene|EPS8-Like 2 Gene|EPS8L2|EPS8R2|FLJ21935|FLJ22171|MGC3088	Human EPS8L2 Gene encodes EPS8-Related Protein 2, a protein of unknown function related to EGFR Pathway Substrate 8 (EPS8), a substrate for the EGFR. (NCI)
C24373	EPS8L3_Gene	Gene_with_Unknown_or_Unclassified_Function	EPS8L3 Gene|EPS8-Like 3 Gene|EPS8L3|EPS8R3|FLJ21522|MGC16817	This gene encodes epidermal growth factor receptor pathway substrate 8-like protein 3 that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Several alternatively spliced transcript variants encoding different isoforms exist. (from LocusLink)
C24374	ERBB2IP_Gene	Trafficking_Protein_Gene	ERBB2IP Gene|ERBB2 Interacting Protein Gene|ERBB2IP|ERBIN	ERBB2 interacting protein; acts as an adaptor for the receptor ERBB2/HER2, which may assist in their localization and signalling function; has a PDZ domain and sixteen leucine-rich repeats (LRRs) (LocusLink)
C24375	EREG_Gene	Growth_Factor_Gene	EREG Gene|ER|EREG|Epiregulin Gene	Encodes epiregulin, a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. (LocusLink)
C24376	ERF_Gene	Transcription_Corepressor_Gene	ERF Gene|ERF|Ets2 Repressor Factor Gene|PE-2	Encodes Ets2 repressor factor, a transcriptional repressor; suppresses ets-induced transformation; contain an Ets-domain (LocusLink)
C24377	ETV1_Gene	ETS_Family_Gene	ETV1 Gene|ER81|ETS Variant Gene 1 Gene|ETV1	This gene encodes Ets variant protein1 that belongs to DNA-binding protein of the ETS family.(LocusLink)
C24378	ETV4_Gene	ETS_Family_Gene	ETV4 Gene|E1A-F|ETS Variant Gene 4 (E1A Enhancer Binding Protein, E1AF) Gene|ETV4|PEAS3	Member of the ets DNA binding protein family; may bind the adenovirus E1A enhancer. (LocusLink)
C24379	EVI2B_Gene	Transmembrane_Protein_Gene	EVI2B Gene|D17S376|EVDB|EVI2B|Ecotropic Viral Integration Site 2B Gene	Expressed as a 2.1-kb transcript in bone marrow, peripheral mononuclear cells, and fibroblasts, human EVI2B Gene encodes 448-aa 49-kDa (precursor) EVI2B Protein, a Pro-rich type I membrane protein containing an N-terminal signal peptide, an extracellular domain with 4 potential glycosylation sites, a hydrophobic transmembrane domain, and a hydrophilic cytoplasmic domain. EVI2B is located between 2 translocation breakpoints in an NF1 intron with EVI2A and OMGP; all are transcribed toward the centromere, opposite to transcription of the NF1 gene. (NCI)
C24380	EXTL1_Gene	Glycosyltransferase_Gene	EXTL1 Gene|EXL1|EXTL|EXTL1|Exostoses (Multiple)-Like 1 Gene	Human EXTL1 Gene (EXT Family) encodes 676-aa 75-kDa Exostosin-Like 1, a type II membrane protein glycosyltransferase of the endoplasmic reticulum with strong sequence similarity to EXT1 and EXT2 and likely involved in chain elongation during heparan sulfate and heparin biosynthesis. (NCI)
C24381	EXTL2_Gene	Glycosyltransferase_Gene	EXTL2 Gene|EXTL2|EXTR2|Exostoses (Multiple)-Like 2 Gene	Ubiquitously expressed as a 3.4-kb transcript, 5-exon human EXTL2 Gene (EXT Family) encodes 330-aa 37.5-kDa Exostosin-Like 2, a type II membrane protein glycosyltransferase of the endoplasmic reticulum that initiates heparan sulfate/heparin biosynthesis by alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate and heparin chains. A soluble EXTL2 form, derived from proteolytic processing of the membrane form, is found in serum. (NCI)
C24382	EXTL3_Gene	Glycosyltransferase_Gene	EXTL3 Gene|EXTL3|EXTR1|Exostoses (Multiple)-Like 3 Gene|KIAA0519|REG|RPR	Ubiquitously expressed as 6.2- and 4.7-kb transcripts, human EXTL3 Gene (EXT Family) encodes 919-aa 105-kDa Exostosin-Like 3, a type II membrane protein glycosyltransferase of the endoplasmic reticulum likely involved in chain initiation and elongation during heparan sulfate/heparin biosynthesis. EXTL3 contains a highly conserved C-terminal region, common to other EXT proteins. (NCI)
C24383	F2R_Gene	G_Protein-Coupled_Receptor_Gene	F2R Gene|CF2R|Coagulation Factor II (Thrombin) Receptor Gene|F2R|PAR1|TR	Expressed in platelets and vascular endothelia, human F2R Gene (GPCR1 Family) encodes 425-aa 47-kDa (precursor) Coagulation Factor II Receptor, a 7-transmembrane G-protein coupled high affinity activated thrombin receptor that stimulates phosphoinositide hydrolysis in the cellular thrombotic response. F2R appears to play a role in platelet activation and vascular development. Receptor phosphorylation probably mediates desensitization prior to uncoupling and internalization. Activated protein C uses EPCR as a coreceptor for cleavage of Coagulation Factor II Receptor on endothelia. Proteolytic cleavage of F2R generates a new N-terminus that functions as a tethered ligand. (NCI)
C24384	FADD_Gene	Adaptor_Signaling_Protein_Gene	FADD Gene|FADD|Fas (TNFRSF6)-Associated via Death Domain Gene|MGC8528|MORT1	Widely expressed, human FADD Gene at 11q13.3 encodes 208-aa 23-kD adaptor protein Fas-Associated Via Death Domain, containing a DED domain, that interacts through its C-terminal death domain with the death domain of cell surface TNFRSF6/FAS-receptor, TNFR, TNFR-2, TNFRSF25, or TNFSF10/TRAIL-receptor and mediates apoptotic signals initiated by these receptors. Interaction with receptor unmasks the FADD N-terminal effector domain allowing it to recruit caspase-8 or caspase-10 and activate the cysteine protease cascade mediating apoptosis. FADD appears required in early T cell development and interacts with CFLAR and PEA15. (NCI)
C24385	FANCG_Gene	DNA_Repair_Gene	FANCG Gene|FAG Gene|FANCG|Fanconi Anemia, Complementation Group G Gene|XRCC9 Gene	With a 5-prime GC-rich region characteristic of a housekeeping gene and expressed in testis, thymus, and lymphoblasts, human FANCG Gene at 9p13 encodes 622-aa 68.5-kD DNA Repair Protein XRCC9, containing an N-terminal leucine-zipper motif and belonging to a multisubunit nuclear protein complex with PHF9, FANCA, FANCC, FANCE, and FANCF. Implicated in interstrand DNA cross-link repair and in maintenance of normal chromosome stability, FANCG may operate in postreplication repair or in a cell cycle checkpoint. (NCI)
C24386	GLMN_Gene	Gene_with_Unknown_or_Unclassified_Function	GLMN Gene|FAB68|FAP48|GLML|GLMN|GVM|Glomulin, FKBP Associated Protein Gene|VMGLOM	The protein encoded by this gene is thought to play a role in coupling hepatocyte growth factor receptor signaling to the p70 S6 protein kinase pathway. It also interacts with the peptidyl prolyl isomerase FK506-binding protein 59 (FKBP59), FKBPP52 and FKBP12. FKBPs belong to the large family of immunophilins that bind the macrolide immunosuppressant drugs FK506 and rapamycin. This gene has two alternatively spliced transcript variants encoding different isoforms. There is evidence for another polyadenylation site further downstream for this gene.(LocusLink)
C24387	FASTK_Gene	Serine-Threonine_Protein_Kinase_Gene	FASTK Gene|FAST|FASTK|FLJ13079|Fas-Activated Serine/Threonine Kinase Gene	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas, human FASTK Gene (Ser/Thr PK Family) at 7q35 encodes 3 alternative isoforms of 549-aa 61-kD Fas-Activated Serine/Threonine Kinase. Rapidly activated during Fas-mediated apoptosis, serine/threonine dephosphorylated FASTK phosphorylates TIA1, a key apoptosis-promoting nuclear RNA-binding protein. (NCI)
C24388	FGF1_Gene	Fibroblast_Growth_Factor_Gene_Family	FGF1 Gene|AFGF|ECGF|ECGF-alpha|ECGF-beta|ECGFA|ECGFB|FGF1|FGFA|Fibroblast Growth Factor 1 (Acidic) Gene|HBGF1	Human FGF1 Gene at 5q31 encodes Fibroblast Growth Factor 1, a modifier of endothelial cell migration and proliferation that may be important in neovascularization.  Acidic Fibroblast Growth Factor and alpha-ECGF are derived from FGF1 by posttranslational processing.  FGF1 causes the foregut endoderm to develop into the liver.  The hepatogenic response is restricted to endoderm tissue, which selectively co-expresses FGF receptors 1 and 4.  Different FGF signals appear to initiate distinct phases of liver development during mammalian organogenesis.  FGF1 binding to FGFR2 is accompanied by binding of a heparin decasaccharide. (NCI)
C24389	FGF10_Gene	Fibroblast_Growth_Factor_Gene_Family	FGF10 Gene|FGF10|Fibroblast Growth Factor 10 Gene|Keratinocyte Growth Factor 2 Gene	The 53-kb 3-exon human FGF10 Gene (FGF Family) at 5p13-p12 encodes secreted 208-aa 23-kDa (precursor) Fibroblast Growth Factor 10, containing 2 putative N-glycosylation sites, a heparin binding domain, and several putative phosphorylation sites and is involved in epidermal brain, lung, and limb bud morphogenesis. Most similar to FGF7, FGF10 is mitogenic in the lung and for keratinizing epidermal cells. FGF10 also appears to be involved tissue repair/wound healing. (NCI)
C24390	FGF20_Gene	Fibroblast_Growth_Factor_Gene_Family	FGF20 Gene|FGF20|Fibroblast Growth Factor 20 Gene	Expressed in brain, 3-exon human FGF20 Gene (FGF Family) at 8p22-p21.3 encodes 211-aa 23.5-kDa Fibroblast Growth Factor 20, containing a strong hydrophobic region in its FGF core domain and a weak hydrophobic N terminal region. FGF20 may enhance the survival of midbrain dopaminergic neurons. (NCI)
C24391	FGF21_Gene	Fibroblast_Growth_Factor_Gene_Family	FGF21 Gene|FGF21|Fibroblast Growth Factor 21 Gene	Human FGF21 Gene (FGF Family) at 19q13.1-qter encodes 209-aa 22-kDa (precursor) Fibroblast Growth Factor 21. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. (NCI)
C24392	FGF8_Gene	Fibroblast_Growth_Factor_Gene_Family	FGF8 Gene|AIGF|FGF8|Fibroblast Growth Factor 8 (Androgen-Induced) Gene|HBGF-8	Human FG8F Gene (FGF Family) at 10q24 encodes alternative isoforms FGF-8A, FGF-8B, FGF-8E, and FGF-8F of secreted autocrine androgen-induced Fibroblast Growth Factor 8, which may be involved in angiogenesis and/or act as an embryonic epithelial factor in midbrain and limb development, in organogenesis, in gastrulation, and in left-right axis determination. Additional isoforms may exist. (NCI)
C24393	FGFR3_Gene	Fibroblast_Growth_Factor_Receptor_Family_Gene	FGFR3 Gene|ACH|CEK2|FGFR3|HSFGFR3EX|JTK4	Expressed in brain, kidney, testis, and widely in fetal tissues, human FGFR3 Gene (FGFR Family) at 4p16.3 encodes 3 alternative isoforms of highly conserved type I membrane protein Fibroblast Growth Factor Receptor 3, consisting of an acidic- and basic-FGF binding extracellular region (containing 3 Ig C2-type domains), a transmembrane segment, and a cytoplasmic tyrosine kinase domain that activates downstream signal cascades involved in mitogenesis and differentiation, as well as bone development and maintenance. FGFR3 defects cause achondroplasia, crouzon syndrome, thanatophoric dysplasia, coronal synostosis, hypochondroplasia, bladder and cervix cancers. (NCI)
C24394	FGFRL1_Gene	Fibroblast_Growth_Factor_Receptor_Family_Gene	FGFRL1 Gene|FGFR5|FGFRL1	The 6-exon human FGFRL1 Gene (FGFR Family) at 4p16 encodes 504-aa 54.6-kDa conserved Fibroblast Growth Factor Receptor-Like 1, consisting of an extracellular region (containing 3 Ig-like domains), a hydrophobic transmembrane segment, and a cytoplasmic tail lacking a tyrosine kinase domain. This protein may interact with other family members and inhibit growth factor signaling. (NCI)
C24395	FHL2_Gene	Transcription_Coactivator_Gene	FHL2 Gene|DRAL|FHL2|Four and A Half LIM Domains 2 Gene|SLIM3	This gene encodes a member of the four-and-a-half-LIM domain (FHL) protein family, which are expressed in a tissue- and stage-specific manner, have been reported to function as transcriptional coactivators. Expression of DRAL (FHL2) results in enhancement of NF-kappaB activation.  DRAL (FHL2) is a p53-responsive gene implicated in induction of apoptosis.  DRAL may participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappaB transcription factor. (from J Biol Chem 2002;277:37045-53 and FEBS Lett 2002;521(1-3):165-9)
C24396	FIBP_Gene	Ligand_Binding_Protein_Gene	FIBP Gene|FGFIBP|FIBP|FIBP-1|Fibroblast Growth Factor (Acidic) Intracellular Binding Protein Gene	Encodes acidic fibroblast growth factor intracellular binding protein; may mediate the mitogenic properties associated with acidic FGF1. (Proteome Summary from LocusLink)
C24397	THSD2_Gene	Gene_with_Unknown_or_Unclassified_Function	THSD2 Gene|FLJ14440|THSD2|Thrombospondin, Type I, Domain Containing 2 Gene	This gene encodes a protein similar to thrombospondin type 1 domain-containing proteins. In addition, the protein contains a furin-like cysteine-rich region. Furin-like repeat domains have been found in a variety of eukaryotic proteins involved in the mechanism of signal transduction by receptor tyrosine kinases. The function of this protein has not been determined.
C24398	FLRT3_Gene	Gene_with_Unknown_or_Unclassified_Function	FLRT3 Gene|FLRT3|Fibronectin Leucine Rich Transmembrane Protein 3 Gene	Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart, human FLRT3 Gene (FLRT Family) at 20p11 encodes 649-aa 73-kDa (precursor) Leucine-Rich Repeat Transmembrane Protein FLRT3, a probable type I membrane protein containing a fibronectin type III domain and 10 leucine-rich repeats that may have a function in cell adhesion and/or receptor signaling. FLRT3 resembles small leucine-rich proteoglycans found in the extracellular matrix and shares 55% amino acid sequence identity with FLRT1 and 44% identity with FLRT2. (NCI)
C24399	FLT3_Gene	Growth_Factor_Receptor_Gene	FLT3 Gene|CD135|FLK2|FLT3|FMS-Related Tyrosine Kinase 3 Gene|STK1	This gene encodes FMS-related tyrosine kinase3, a growth factor receptor in hematopoietic stem and progenitor cells. (LocusLink)
C24400	FLT4_Gene	Growth_Factor_Receptor_Gene	FLT4 Gene|FLT4|FMS-Related Tyrosine Kinase 4 Gene|PCL|VEGFR3|VGR3	This gene encodes FMS-related receptor tyrosine kinase 4; a endothelial cell-specific receptor; and is similar to vascular endothelial growth factor VEGF (LocusLink)
C24401	FGFR1OP_Gene	Gene_with_Unknown_or_Unclassified_Function	FGFR1OP Gene|FGFR1 Oncogene Partner Gene|FOP	The 13-exon 40-kb human FGFR1OP Gene at 6q27 encodes ubiquitous 399-aa 43-kDa hydrophilic FGFR1 Oncogene Partner protein, containing N- and C-terminal alpha helices harboring leucine-rich repeats. t(6;8)(q27;p11), fusing FOP and FGFR1, has been found in myeloproliferative disorders. The chimeric protein contains the N-terminal FOP leucine-rich region fused to the FGFR1 catalytic domain. FOP may play a role in erythroid cell proliferation and differentiation. (NCI)
C24402	FOXO1A_Gene	Transcription_Factor_Gene	FOXO1A Gene|FKH1|FKHR|FOXO1A|Forkhead Box O1A (Rhabdomyosarcoma) Gene	This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. (LocusLink)
C24403	FPR1_Gene	G_Protein-Coupled_Receptor_Gene	FPR1 Gene|FMLP|FPR|FPR1|Formyl Peptide Receptor 1 Gene	Formyl peptide receptor 1, a G protein-coupled receptor; binds bacterial N-formyl-methionyl peptides (LocusLink)
C24404	FRAG1_Gene	Gene_with_Unknown_or_Unclassified_Function	FRAG1 Gene|FGF Receptor Activating Protein 1 Gene|FRAG1	FRAG1 has been found fused to the C terminus of FGFR2 in rat osteosarcoma cells where it drastically stimulates the transforming activity and autophosphorylation of the receptor.  Human FRAG1 encodes a novel membrane-spanning protein that localizes to chromosome 11p15.5, a region implicated in Beckwith-Wiedemann syndrome and a region of frequent loss of heterozygosity in multiple tumor types. (from Proc Natl Acad Sci 1996;93:8956-61 and Genomics 1999;62:59-66)
C24405	FRAT1_Gene	Gene_with_Unknown_or_Unclassified_Function	FRAT1 Gene|FRAT1|Frequently Rearranged in Advanced T-Cell Lymphomas Gene	The gene FRAT1 (for 'frequently rearranged in advanced t-cell lymphomas') was identified as one that is frequently mutated by proviral insertion during later stages of T-cell lymphomagenesis in mouse systems. All proviral insertions left the coding domain intact, suggesting that it is overexpression of the normal gene that contributes to transformation. The human FRAT1 gene was cloned using the mouse gene as a probe. It encodes a polypeptide of 279 amino acids that is 79% identical to the mouse protein. Human FRAT1 promotes carcinogenesis through activation of the WNT signaling pathway. The protein can bind to glycogen synthase kinase-3 (GSK-3) and Dishevelled, two proteins involved in WNT signal transduction. (from OMIM 602503, Int J Oncol 2002;20:785-9 and Gene 2002;291:17-27)
C24406	FRK_Gene	SRC_Family_Gene	FRK Gene|FRK|FYN-Related Kinase Gene|GTK|RAK	Human FRK Gene (SRC Family) at 6q21-q22.3 encodes 505-aa 58-kDa FYN-Related Kinase (tyrosine kinase), containing a putative ATP-binding motif, tyrosine kinase motifs, and SH2 and SH3 domains. FRK lacks a myristylation signal, has autophosphorylation activity, is C-terminal tyrosine phosphorylated by CSK, and may function during G1/S and suppress growth. (NCI)
C24407	FRSB_Gene	Gene_with_Unknown_or_Unclassified_Function	FARSLB Gene|FARSLB|FRSB|PheHB|Phenylalanine-tRNA Synthetase-Like, Beta Subunit Gene	Human FRSB Gene at 2q36.1 encodes the non-catalytic beta subunit of heterodimeric (alpha/beta) 2 Phenylalanyl-tRNA Synthetase. The two subunits are coordinately overexpressed in an acute-phase chronic myeloid leukemia cell line. (Biochem Biophys Res Commun 1999;255:765-73)
C24408	FSTL3_Gene	Ligand_Binding_Protein_Gene	FSTL3 Gene|FLRG|FSRP|FSTL3|Follistatin-Like 3 (Secreted Glycoprotein) Gene	Follistatin-like-3 (FSTL3) is a secreted glycoprotein that binds to activin and is highly homologous to follistatin, an activin ligand. It is a member of the follistatin-module protein family, which is composed of extracellular matrix-associated glycoproteins thought to act in a paracrine manner to bind morphogens or growth/differentiation factors and regulate their activity during development. In addition to the t(11;19) translocation in a case of B-cell chronic lymphocytic leukemia from which FSTL3 was isolated, rearrangement of the FSTL3 gene was also observed in a case of B-cell non-Hodgkin lymphoma and in a case of B-cell mantle zone lymphoma, suggesting that FSTL3 may be involved in the leukemogenesis process.(OMIM)
C24409	PDAP2_Gene	Gene_with_Unknown_or_Unclassified_Function	TUSC2 Gene|FUS1|PDAP2|PDAP2 Gene|Tumor Suppressor Candidate 2 Gene	A candidate tumor suppressor gene identified in the 120 kb 3p21.3 critical region contained in nested lung and breast cancer homozygous deletions. Overexpression of Fus1 protein significantly inhibited tumor cell growth by induction of apoptosis and alteration of cell cycle processes in 3p21.3 120-kb region-deficient (homozygous) non-small cell lung cancer cell lines (from Cancer Res 2002;62:2715-20)
C24410	FVT1_Gene	Gene_with_Unknown_or_Unclassified_Function	FVT1 Gene|FVT1|Follicular Lymphoma Variant Translocation 1 Gene|Leucine Rich Repeat Neuronal 5 Gene	Identified as the fusion partner of a J-kappa segment translocation in a follicular lymphoma.  This evolutionarily conserved gene, termed FVT1 for follicular-variant-translocation gene, codes for a putatively secreted protein of 36 kd that was not homologous with any described protein. It was weakly expressed in all the analyzed normal hematopoietic tissues but showed a very high rate of transcription in some T-cell malignancies and in phytohemagglutinin-stimulated lymphocytes. (from OMIM 136440)
C24411	FZD2_Gene	G_Protein-Coupled_Receptor_Gene	FZD2 Gene|FZD2|Frizzled 2 Gene|Frizzled-2|Fz-2|FzE2|hFz2	The human FZD2 gene at 17q21.1 of the frizzled gene family encodes Frizzled 2, which is a 7-transmembrane domain protein that is a receptor with a role in transmembrane signal transmission for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary. (From LocusLink and NCI)
C24412	FZD3_Gene	G_Protein-Coupled_Receptor_Gene	FZD3 Gene|FZD3|Frizzled 3 Gene|Frizzled Homolog 3 (Drosophila) Gene|Fz-3 Gene|hFz3 Gene	The human FZD3 gene at 8p21 encodes Frizzled 3, which is a G protein-coupled receptor for Wnt proteins and regulates signal transduction in endothelial cells via beta-catenin. It may function in both normal and pathological vasculature differentiation. It also may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Two isoforms are produced by alternative splicing. This protein is widely expressed with relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis. (From LocusLink, Swiss-Prot and NCI)
C24413	FZD4_Gene	G_Protein-Coupled_Receptor_Gene	FZD4 Gene|FZD4|Frizzled 4 Gene|Frizzled Homolog 4 (Drosophila) Gene	The human FZD4 gene at 11q14.2 encodes Frizzled 4, which is a G protein-coupled receptor that has seven transmembrane domains. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. It may function in cell polarity, cell fate specification and cancer. (From LocusLink, Swiss-Prot and NCI)
C24414	FZD6_Gene	G_Protein-Coupled_Receptor_Gene	FZD6 Gene|FZD6|Frizzled 6 Gene|Frizzled Homolog 6 (Drosophila) Gene	The human FZD6 gene at 8q22.3-q23.1 encodes Frizzled 6, which is a G protein-coupled receptor for Wnt signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other Fz family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif. Frizzled 6 may function in tissue polarity, development and carcinogenesis. (From LocusLink and NCI)
C24415	FZD7_Gene	G_Protein-Coupled_Receptor_Gene	FZD7 Gene|FZD7|Frizzle 7 Gene|Frizzled 7 Gene|Frizzled Homolog 7 (Drosophila) Gene|Frizzled-7 Gene|Fz-7 Gene|FzE3 Gene|hFz7 Gene	The human FZD7 gene at 2q33 encodes Frizzled 7, which is a G protein-coupled receptor for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression downregulates APC function and enhances beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. (From LocusLink and NCI)
C24416	FZD9_Gene	G_Protein-Coupled_Receptor_Gene	FZD9 Gene|FZD9|Frizzled 9 Gene|Frizzled Homolog 9 (Drosophila) Gene	The human FZD9 gene at 7q11.23 encodes Frizzled 9, which is a G protein-coupled receptor for Wnt signaling proteins. This gene has been first described as FZD3 in literature. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. Frizzled 9 may function in tissue polarity, development and carcinogenesis. Heterozygous deletion of the FZD3 gene may contribute to the Williams syndrome phenotype. (From LocusLink and NCI)
C24417	GAB2_Gene	Adaptor_Signaling_Protein_Gene	GAB2 Gene|GAB2|GRB2-Associated Binding Protein 2 Gene	The human GAB2 gene at 11q13.3 is a member of the GRB2-associated binding protein (GAB) gene family and encodes GRB2-Associated Binding Protein 2 (GAB2). GAB2 is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Upon tyrosine phosphorylation, GAB2 interacts with SHP2 tyrosine phosphatase and GRB2 adapter protein. It is the limiting component of the GAB2-SHP2 complex, signaling Erk MAP kinase activation and terminal differentiation of K562 CML cells. GAB2 also has an inhibitory effect on the activation of ELK1-dependent transcription triggered by a dominant active Ras mutant or under growth factor stimulation. Two alternatively spliced transcripts encode different isoforms and the short isoform is the main isoform. This protein is overexpressed and estrogen regulated in human breast cancer. (From LocusLink, OMIM and NCI)
C24418	GAC1_Gene	Gene_with_Unknown_or_Unclassified_Function	LRRN5 Gene|GAC1|Glioma Amplified on Chromosome 1 Protein (Leucine-Rich) Gene|LRANK1|LRRN5|Leucine Rich Repeat Neuronal 5 Gene	The human GAC1 gene at 1q32.1 encodes Glioma Amplified on Chromosome 1 Protein, which belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. GAC1 has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. (From LocusLink and NCI)
C24419	GADD45A_Gene	Signaling_Pathway_Gene	GADD45A Gene|GADD45A|Growth Arrest and DNA-Damage-Inducible, Alpha Gene	The GADD45A gene at 1p31.2-p31.1 encodes Growth Arrest and DNA-Damage-Inducible, Alpha, which is widely expressed in normal tissues and its expression is increased by DNA damage. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. The GADD45A protein responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. This nuclear protein interacts with the proliferating cell nuclear antigen (PCNA), a component of DNA replication/repair complexes, and the cyclin dependent kinase inhibitor p21Cip1.
C24420	GALR2_Gene	G_Protein-Coupled_Receptor_Gene	GALR2 Gene|GALR2|Galanin Receptor 2 Gene	Human GALR2 Gene at 17q25.3 encodes 387-aa 42-kDa Galanin Receptor 2, a GPCR for neuromodulatory peptide galanin that stimulates growth hormone secretion, inhibits vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. Galanin Receptor 2 decreases cAMP through an inhibitory G-protein and stimulates phospholipase C and mobilizes calcium through Gq/G11. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq). (NCI)
C24421	GAS41_Gene	Gene_with_Unknown_or_Unclassified_Function	YEATS4 Gene|GAS41|GAS41 Gene|Glioma-Amplified Sequence-41 Gene|NUBI-1|YEATS Domain Containing 4 Gene|YEATS4	The human GAS41 gene at 12q13-q15 encodes Glioma-Amplified Sequence-41, which may be a transcription factor and common binding factor for the TACC family proteins. An increased copy number of this gene is found in glioblastoma multiforme and astrocytoma III, and at a high frequency in astrocytoma grades I and II. The GAS41 gene is the first gene found with increased copy number in low-grade glioma, which provides the first evidence that gene amplification can occur in early tumor development. (From OMIM and NCI)
C24422	GCG_Gene	Peptide_Hormone_Gene	GCG Gene|GCG|GLP1|GLP2|GRPP|Glucagon Gene	The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon. (LocusLink)
C24423	GDF10_Gene	Bone_Morphogenetic_Protein_Gene	GDF10 Gene|BMP3B|GDF10|Growth Differentiation Factor 10 Gene	The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis. (LocusLink)
C24424	GDF5_Gene	Bone_Morphogenetic_Protein_Gene	GDF5 Gene|GDF5|Growth Differentiation Factor 5 Gene	The human GDF5 gene at 20q11.2 encodes Growth Differentiation Factor 5, which is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein is predominantly expressed in long bones during human embryonic development. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. (From LocusLink, Swiss-Prot and NCI)
C24425	GDF8_Gene	Bone_Morphogenetic_Protein_Gene	GDF8 Gene|GDF8|Growth Differentiation Factor 8 Gene	The human GDF8 gene at 2q32.2 encodes Growth Differentiation Factor 8, which is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein plays a role in the control and maintenance of skeletal muscle mass. It acts specifically as a negative regulator of skeletal muscle growth by signaling through receptor serine/threonine kinases. This protein is synthesized as a preprotein activated by 2 proteolytic cleavages. Removal of the signal sequence is followed by cleavage at a tetrabasic processing site, resulting in a 26-kD amino-terminal propeptide and a 12.5-kD carboxy-terminal peptide, a dimer of which is the biologically active portion of the protein. (From LocusLink, OMIM and NCI)
C24426	GDF9_Gene	Transforming_Growth_Factor-Beta_Family_Gene	GDF9 Gene|GDF-9|GDF9|Growth Differentiation Factor 9 Gene	The human GDF9 gene at 5q31.1 encodes Growth Differentiation Factor 9, which is a member of the TGF-beta superfamily. This protein interacts with bone morphogenetic protein-15 and Bone morphogenetic protein receptor type II is a receptor for Growth Differentiation Factor-9. Both GDF9 mRNA and protein are abundantly expressed in oocytes of primary follicles in human ovary, suggesting that the GDF9 transcript is translated at this early stage of folliculogenesis. GDF9 is crucial for normal ovarian folliculogenesis and female fertility. GDF9 regulates human folliculogenesis in a manner specific to the ovary. A dysregulation of GDF9 expression may contribute to aberrant folliculogenesis in PCOS and PCO women. (From OMIM, Swiss-Prot and NCI)
C24427	GFI1B_Gene	Transcription_Factor_Gene	GFI1B Gene|GFI1B|Growth Factor Independence-1B Gene|Growth Factor Independent 1B (Potential Regulator of CDKN1A, Translocated in CML) Gene	The human GFI1B gene at 9q34.13 encodes Growth Factor Independence-1B, which is a zinc finger protein. This protein is a transcription factor with specific involvement in the regulation of erythroid cell growth in normal erythropoiesis through modulating erythroid-specific gene expression. The function of GFI1B to modulate transcription depends on promoter context. Human GFI1B expression by Northern blot analysis is highest in bone marrow and fetal liver as well as in the chronic myeloid leukemia cell line K562 with lower levels in other hematopoietic precursor cells. Expression of GFI1B is highly restricted to hematopoietic stem cells, erythroblasts, and megakaryocytes. Its expression does not promote erythroid commitment, but enhances proliferation of immature erythroblasts. The chromosomal region of this gene is translocated to chromosome 22q11 in chronic myeloid leukemia (From OMIM, PubMed 12351384 and NCI)
C24428	GFRA2_Gene	Receptor_Gene	GFRA2 Gene|GDNF Family Receptor Alpha 2 Gene|GDNF Family Receptor Alpha-2 Gene|GDNF Receptor Beta Gene|GDNFR-Beta Gene|GDNFRB|GFR-Alpha 2 Gene|GFRA2|Glial Cell Line Derived Neurotrophic Factor Receptor, Beta Gene|Glial Cell Line-Derived Neurotrophic Factor Receptor Beta Gene|NRTNR-Alpha Gene|NTNR-Alpha Gene|NTNRA|Neurturin Receptor Alpha Gene|PI-Linked Cell-Surface Accessory Protein Gene|RET Ligand 2 Gene|RETL2|TGF-Beta Related Neurotrophic Factor Receptor 2 Gene|TRN Receptor, GPI-Anchored Gene|TRNR2	The human GFRA2 gene at 8p21 encodes GDNF Family Receptor Alpha 2, which is a member of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) Receptor family. GDNF and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 is required for the development of the myenteric nerve plexus. This protein is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This receptor acts preferentially as a receptor for NTN compared to its other family member, GDNF Family Receptor Alpha 1. Two alternatively spliced transcript variants, long and short, have been described for this gene but their full length nature is not known. The short form is found in brain and placenta. This gene is a candidate gene for RET-associated diseases. (From LocusLink, OMIM, Swiss-Prot and NCI)
C24429	GIPR_Gene	G_Protein-Coupled_Receptor_Gene	GIPR Gene|GIPR|Gastric Inhibitory Polypeptide Receptor Gene	This gene encodes gastric inhibitory polypeptide (glucose-dependent insulinotropic polypeptide) receptor; signals through stimulatory G-protein to increase intracellular cAMP; member of the G protein-coupled receptor family. (Proteome Summary from LocusLink)
C24430	GIT1_Gene	Signaling_Pathway_Gene	GIT1 Gene|G Protein-Coupled Receptor Kinase Interactor 1 Gene|GIT1	This gene encodes G Protein-Coupled Receptor Kinase-Interactor 1: GIT1 is a multidomain protein that is thought to function as an integrator of signaling pathways controlling vesicle trafficking, adhesion and cytoskeletal organization. (from J Cell Sci 2002 Apr 1;115(Pt 7):1497-510)
C24431	GIT2_Gene	Signaling_Pathway_Gene	GIT2 Gene|CAT-2|G Protein-Coupled Receptor Kinase Interactor 2 Gene|GIT2|KIAA0148	This gene encodes a member of the GIT protein family. GIT proteins interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. This gene undergoes extensive alternative splicing. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.
C24432	GLI_Gene	GLI_Family_Gene	GLI1 Gene|GLI|GLI Gene|GLI1|Glioma-Associated Oncogene Homolog|Glioma-Associated Oncogene Homolog 1 (Zinc Finger Protein) Gene	Human GLI1 Gene (GLI/Kr family) at 12q13.2-q13.3 is homologous to Ci (Drosophila), which encodes a gap class chromatin-associated phosphoprotein.  GLI1 encodes GLI1 Protein, containing five DNA-binding C2H2 zinc finger repeats implicated in transcription of SHH signaling target genes; a putative endodermal signal that controls hindgut patterning and lung growth.  Kr family members are expressed in embryonic cells, but not in most adult tissue.  (from SWISS-PROT, OMIM, and NCI)
C24433	GLTSCR1_Gene	Gene_with_Unknown_or_Unclassified_Function	GLTSCR1 Gene|GLTSCR1|Glioma Tumor Suppressor Candidate Region Gene 1 Gene	The human GLTSCR1 gene at 19q13.3 encodes Glioma Tumor Suppressor Candidate Region Gene 1 Protein. Northern blot analysis detects expression of a 6.5-kb GLTSCR1 transcript at moderate levels in heart, brain, placenta, skeletal muscle, and pancreas, and at lower levels in lung, liver, and kidney. Mutation analysis of the transcripts in this region in diffuse gliomas with 19q deletions reveals no tumor-specific mutations. However, a marker in GLTSCR1, presumably separated from RAI by several million bases, supplements the most significant marker in RAI in separating cases of basal cell carcinoma (BCC) from controls, which may suggest the presence of an independent, risk-modulating variation in this second gene region. (From OMIM, Swiss-Prot, PubMed 12117772 and NCI)
C24434	GLTSCR2_Gene	Gene_with_Unknown_or_Unclassified_Function	GLTSCR2 Gene|GLTSCR2|Glioma Tumor Suppressor Candidate Region Gene 2 Gene	The human GLTSCR2 gene at 19q13.3 encodes Glioma Tumor Suppressor Candidate Region Gene 2 Protein, which interacts with HSV-1 early proteins ICP22 and ICP0. Northern blot analysis detects expression of a 1.5-kb GLTSCR2 transcript at high levels in heart and pancreas, moderate levels in placenta, liver, skeletal muscle, and kidney, and low levels in brain and lung. Mutation analysis of the transcripts in this region in diffuse gliomas with 19q deletions reveals no tumor-specific mutations. (From OMIM, Swiss-Prot and NCI)
C24435	GNA12_Gene	Heterotrimeric_G_Protein_Subunit_Gene	GNA12 Gene|GNA12|Guanine Nucleotide Binding Protein (G Protein) Alpha 12 Gene|NNX3|RMP	G-protein alpha subunit 12; couples to thrombin and thromboxane A2 receptors in platelets (LocusLink)
C24436	GNAI2_Gene	Heterotrimeric_G_Protein_Subunit_Gene	GNAI2 Gene|GIP|GNAI2|GNAI2B|Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 2 Gene	Single copy human GNAI2 Gene (G-Alpha 1 Family) encodes 354-aa 40-kDa G(i) Alpha 2 Protein, a guanine nucleotide-binding alpha protein subunit of heterotrimeric G protein transducers (alpha, beta, gamma) in transmembrane signaling systems involved in hormonal regulation of adenylate cyclase. At least 3 nonallelic human genes encode alpha-i-type G protein subunits; GNAI2 and GNAI3 possess identical exon-intron organization. Containing virtually identical/similar beta and gamma chains, G proteins are most distinguished by alpha chains. G(i) proteins (alpha(i) subunit) inhibit cyclase in response to beta-adrenergic stimuli. Specific alpha chain regions appear to interact with guanine nucleotides, receptors, effector enzymes, and G protein beta-gamma complex. G proteins that inhibit adenylate kinase are substrates for pertussis toxin. GNAI2 mutations affect cell proliferation. (NCI)
C24437	GNAZ_Gene	Heterotrimeric_G_Protein_Subunit_Gene	GNAZ Gene|GNAZ|Guanine Nucleotide Binding Protein (G Protein), Alpha Z Polypeptide Gene	Guanine nucleotide binding protein is a member of a G protein subfamily that mediates signal transduction; component of pertussis toxin-insensitive (PTX) heterotrimeric G-protein complexes. (LocusLink)
C24438	GNB1_Gene	Heterotrimeric_G_Protein_Subunit_Gene	GNB1 Gene|GBB1|GNB1|Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 1 Gene	Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene uses alternative polyadenylation signals. (LocusLink)
C24439	GNB2_Gene	Heterotrimeric_G_Protein_Subunit_Gene	GNB2 Gene|GBB2|GNB2|Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 2 Gene	With an upstream CCG repeat length polymorphism and expressed in oocytes and blastocysts, human GNB2 Gene at 7q22 encodes 340-aa 37-kDa Guanine Nucleotide Binding Protein Beta 2, a heterotrimeric G protein beta subunit with 7 WD repeats and involved in transmembrane signaling as a transducer that regulates G protein alpha subunits and integrates signals between receptors and effector proteins. The G protein beta and gamma subunits are required for GTPase activity, for GTP replacement of GDP, and for G protein/effector interaction. (NCI)
C24440	GNB3_Gene	Heterotrimeric_G_Protein_Subunit_Gene	GNB3 Gene|GBB3|GNB3|Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 3 Gene	Human GNB3 Gene at 12p13 encodes 340-aa 37-kDa Guanine Nucleotide Binding Protein Beta 3, a heterotrimeric G protein beta subunit with 7 WD repeats and involved in transmembrane signaling as a transducer that regulates G protein alpha subunits and integrates signals between receptors and effector proteins. The G protein beta and gamma subunits are required for GTPase activity, GTP for replacement of GDP, and for G protein/effector interaction. A splicing-associated single-nucleotide polymorphism (C825T) is associated with essential hypertension and obesity. (NCI)
C24441	GPA33_Gene	Immunoglobulin_Family_Gene	GPA33 Gene|A33|GPA33|Glycoprotein A33 (Transmembrane) Gene	The glycoprotein encoded by this gene is a cell surface antigen that is expressed in normal human colon and small intestine epithelia and in greater than 95% of human colon cancers. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. It may function as a cell surface receptor or play a role in cell adhesion. (LocusLink and OMIM)
C24442	GPR17_Gene	G_Protein-Coupled_Receptor_Gene	GPR17 Gene|G Protein-Coupled Receptor 17 Gene|GPR17|GR17|R12	Expressed in brain, human GPR17 Gene (GPCR1 Family) at 2q21 encodes in 2.3-/6.3-kb mRNAs alternative isoforms 1 and 2 of 339-/367-aa 41-kDa integral membrane protein G Protein-Coupled Receptor 17, a putative purine receptor containing 7 transmembrane domains that transduces extracellular signals through heterotrimeric G proteins. GPR17 gene organization differs from many other GPCRs; the open reading frame is distributed on 2 exons with an additional 5-prime UTR exon. (NCI)
C24443	GPR2_Gene	G_Protein-Coupled_Receptor_Gene	CCR10 Gene|CC Chemokine Receptor 10 Gene|CCR10|Chemokine (C-C Motif) Receptor 10 Gene|GPR2|GPR2 Gene	The GPR2 gene encodes G Protein-Coupled Receptor 2, which is the receptor for CCL27. The interactions between this receptor and CCL27 are involved in T cell-mediated skin inflammation. (from LocusLink)
C24444	GPR32_Gene	G_Protein-Coupled_Receptor_Gene	GPR32 Gene|G Protein-Coupled Receptor 32 Gene|GPR32	Human GPR32 Gene (GPCR1 Family) at 19q13.3 encodes 356-aa 40-kDa integral membrane protein G Protein-Coupled Receptor 32, an orphan receptor with greatest similarity to chemoattractant receptors, particularly the formylpeptide receptor (FPR1). (NCI)
C24445	GPR68_Gene	G_Protein-Coupled_Receptor_Gene	GPR68 Gene|G Protein-Coupled Receptor 68 Gene|GPR68|OGR1	Expressed as a 3-kb transcript in spleen, testis, peripheral leukocytes, brain, lung, and placenta, GPR68 Gene (GPCR1 Family) at 14q31 encodes 365-aa 41-kDa 7-transmembrane G Protein-Coupled Receptor 68, a high affinity receptor for sphingosylphosphorylcholine that acts as a proton-sensing receptor and stimulates PI hydrolysis. The receptor is inactive at pH 7.8 and fully activated at pH 6.8; extracellular histidines are involved in pH sensing. (NCI)
C24446	CXCR3_Gene	Chemokine_Receptor_Gene	CXCR3 Gene|CD183|CKR-L2|CMKAR3|CXCR3|Chemokine (C-X-C Motif) Receptor 3 Gene|GPR9|IP10|IP10-R|Mig-R|MigR	Encodes CD183, a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to CD183. A hallmark of CD183 is its prominent expression in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that CD183 and its chemokines participate in the recruitment of inflammatory cells. (from LocusLink)
C24447	GPRC5C_Gene	G_Protein-Coupled_Receptor_Gene	GPRC5C Gene|G Protein-Coupled Receptor, Family C, Group 5, Member C Gene|GPRC5C|RAIG-3|RAIG3|Retinoic Acid-Inducible Gene 3	Expressed in stomach, kidney, liver, lung, pancreas, central nervous system, and prostate, human GPRC5C Gene (GPCRc Family) at 17q25 encodes 441-aa 48-kDa 7-transmembrane G Protein-Coupled Receptor Family C Group 5 Member C, with an extracellular N-terminal domain, an intracellular C-terminal domain, and conserved cysteines residues. The specific protein function is unknown; it may mediate retinoic acid effects on G protein signal transduction. (NCI)
C24448	GPRK2L_Gene	G_Protein-Coupled_Receptor_Kinase_Gene	GRK4 Gene|G Protein-Coupled Receptor Kinase 4 Gene|GPRK2L|GPRK2L Gene|GPRK4|GRK4	Expressed primarily in testis and brain, 16-exon 75-kb human GPRK2L Gene (GPRK Family) at 4p16.3 encodes 4 alternative isoforms (GRK4A, B, C, D) of 578-/546-/532-aa 67-kDa G Protein-Coupled Receptor Kinase 2-Like, a Ser/Thr kinase containing an RGS domain that phosphorylates activated GPCRs and may play a role in receptor desensitization. Only full-length GRK4D has kinase activity, can phosphorylate rhodopsin, and is inhibited by calmodulin. The other isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. (NCI)
C24449	GPRK5_Gene	G_Protein-Coupled_Receptor_Kinase_Gene	GPRK5 Gene|G Protein-Coupled Receptor Kinase 5 Gene|GPRK5|GRK5	Expressed in heart, placenta, lung, skeletal muscle, brain, liver, pancreas, and kidney, human GPRK5 Gene (GPRK Family) at 10q24-qter encodes 590-aa 68-kDa G Protein-Coupled Receptor Kinase 5, which contains an RGS domain and specifically Ser/Thr phosphorylates and regulates activated forms of GPCRs. (NCI)
C24450	GPRK6_Gene	G_Protein-Coupled_Receptor_Kinase_Gene	GRK6 Gene|G Protein-Coupled Receptor Kinase 6 Gene|GPRK6|GPRK6 Gene|GRK6	The GPRK6 gene encodes G Protein-Coupled Receptor Kinase 6, which belongs to the GPRK subfamily of the Ser/Thr family of protein kinases. It specifically phosphorylates the activated forms of G protein-coupled receptors. Two alternative splicing forms exist. (from Swiss-Prot)
C24451	GPRK7_Gene	G_Protein-Coupled_Receptor_Kinase_Gene	GRK7 Gene|G Protein-Coupled Receptor Kinase 7 Gene|G protein-coupled receptor kinase 7|GPRK7|GPRK7 Gene|GRK7	Expressed in retina, 4-exon 10-kb human GPRK7 Gene (GPRK family) at 3q21-q23 encodes membrane-bound 553-aa 62-kDa G Protein-Coupled Receptor Kinase 7, a Ser/Thr kinase containing an RGS domain, a C-terminal CaaX motif for isoprenylation and carboxymethylation, an autophosphorylation site (Ser491), and a geranylgeranylation motif. GRK7 catalyzes rhodopsin phosphorylation, initiating their deactivation in a light-dependent manner. (NCI)
C24452	GPS1_Gene	Signaling_Pathway_Gene	GPS1 Gene|COPS1|G Protein Pathway Suppressor 1 Gene|GPS1	Human GPS1 Gene at 17q25.3 encodes 471-aa 53-kDa G Protein Pathway Suppressor 1 Protein, containing a PCI domain and with similarity to signal transduction regulator FUS6 (Arabidopsis). GPS1 suppresses G-protein- and MAP kinase-mediated signal transduction. (NCI)
C24453	GPS2_Gene	Signaling_Pathway_Gene	GPS2 Gene|AMF-1|G Protein Pathway Suppressor 2 Gene|GPS2|KIAA1787	Human GPS2 Gene at 17p13 encodes 2 isoforms of 327-aa 37-kDa G Protein Pathway Suppressor 2 Protein, a protein that suppresses RAS and MAP kinase signal transduction and interferes with c-JNK activation. GPS2 is an integral subunit of NCOR1/HDAC3 complex. GPS2 and TBL1 in NCOR1/HDAC3 interact with NCOR1 repression domain-1 to link to HDAC3 via the NCOR1 SANT domain, which activates HDAC3 activity. NCOR1/HDAC3 inhibits JNK activation through GPS2. GPS also interacts with E2 and E6 proteins. (NCI)
C24454	GR6_Gene	Gene_with_Unknown_or_Unclassified_Function	GR6 Gene|GR6|Putative GR6 Protein Gene	Normally expressed in early fetal development, human GR6 Gene at 3q21 in the leukemia breakpoint region encodes 149-aa 16-kDa GR6 Protein, function unknown. (from Cancer Res 1997;57:3914-9)
C24455	GRAP_Gene	Adaptor_Signaling_Protein_Gene	GRAP Gene|GRAP|GRB2-Related Adaptor Protein Gene	This gene encodes a member of the GRB2/Sem5/Drk family. This member functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. Expression is restricted to lymphoid tissues.(LocusLink)
C24456	GRB10_Gene	Adaptor_Signaling_Protein_Gene	GRB10 Gene|GRB-IR|GRB10|Growth Factor Receptor-Bound Protein 10 Gene|IRBP|KIAA0207|MEG1|RSS	This gene encodes growth factor receptor-bound protein 10. This gene product interacts with IGF1R, PDGFRB, and EGFR and binds to the Raf-1 and MEK1 kinases. Its cellular role is still unclear and a positive as well as an inhibitory role in mitogenesis depending on the cell context has been implicated.  Grb10 may regulate signaling between plasma membrane receptors and the apoptosis-inducing machinery on the mitochondrial outer membrane. (from LocusLink, J Biol Chem 1999;274:35719-24, and Mol Cell Biol 1999;19:6217-28)
C24457	GRB14_Gene	Adaptor_Signaling_Protein_Gene	GRB14 Gene|GRB14|Growth Factor Receptor-Bound Protein 14 Gene	Member of the GRB7 family of adapter proteins; identified as a partner of the insulin receptor where it acts as a modulator of insulin signaling. (from J Biol Chem 2002;277:4845-52)
C24458	GRB2_Gene	Adaptor_Signaling_Protein_Gene	GRB2 Gene|GRB2|Growth Factor Receptor-Bound Protein 2 Gene	GRB2 is the homolog of the Sem5 gene of C. elegans and the Drk gene of Drosophila. GRB2 forms a complex with activated EGFR and the RAS-specific guanine nucleotide exchange factor SOS1, thereby mediating the growth factor-induced activation of RAS. It also acts to link PDGFRB to the Rac signaling pathway. Due to its ability to cause complex formation between proteins involved in growth signaling pathways, GRB2 has been referred to as an adaptor protein. (from LocusLink and OMIM)
C24459	GRB7_Gene	Adaptor_Signaling_Protein_Gene	GRB7 Gene|GRB7|Growth Factor Receptor-Bound Protein 7 Gene	This gene encodes growth factor receptor-bound protein 7. It is an adapter-type signaling protein, which is recruited via its SH2 domain to a variety of receptor tyrosine kinases (RTKs), including ErbB2 and ErbB3. Grb7 has been implicated as a downstream mediator of integrin-FAK signal pathways in the regulation of cell migration, although the molecular mechanisms are still not well understood. It is overexpressed in breast, esophageal, and gastric cancers, and may contribute to the invasive potential of cancer cells.(from J Biol Chem 2002;277:29069-77 and J Biol Chem 2002;277:11918-26)
C24460	GRF2_Gene	Retired_Concepts	GRF2 Gene|C3G|GRF2	GRF2 is a human guanine nucleotide releasing protein for Ras protein. (from LocusLink)
C24461	GRIA3_Gene	Receptor_Gene	GRIA3 Gene|AMPA 3|GLUR3|GLURC|GRIA3|Glutamate Receptor, Ionotrophic, AMPA 3 Gene	This gene encodes subunit 3 of the AMPA subtype of ionotropic glutamate receptor; important for excitatory neurotransmission
C24462	GRM1_Gene	G_Protein-Coupled_Receptor_Gene	GRM1 Gene|GPRC1A|GRM1|GRM1A|Glutamate Receptor, Metabotropic 1 Gene|MGLUR1|MGLUR1A|mGlu1	This gene encodes metabotropic 1 of glutamate Receptor. The metabotropic glutamate receptors are a family of G protein-coupled neurotransmitter receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. (LocusLink)
C24463	GRM5_Gene	G_Protein-Coupled_Receptor_Gene	GRM5 Gene|GPRC1E|GRM5|Glutamate Receptor, Metabotropic 5 Gene|MGLUR5|MGLUR5A|MGLUR5B|mGlu5	The metabotropic glutamate receptors are a family of G protein-coupled neurotransmitter receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties; activates phospholipase C and calcium-induced chloride channels (LocusLink)
C24464	GRM6_Gene	G_Protein-Coupled_Receptor_Gene	GRM6 Gene|GPRC1F|GRM6|Glutamate Receptor, Metabotropic 6 Gene|MGLUR6|mGlu6	This gene encodes metabotropic 6 of glutamate Receptor. The metabotropic glutamate receptors are a family of G protein-coupled neurotransmitter receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. (LocusLink)
C24465	GSTT1_Gene	Transferase_Gene	GSTT1 Gene|GSTT1|Glutathione S-Transferase Theta 1 Gene	This gene encodes glutathione S-transferase theta 1, a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. The theta class includes GSTT1 and GSTT2. In humans, the GSTT1 enzyme is found in the erythrocyte and this may act as a detoxification sink. (LocusLink and OMIM)
C24466	HDAC5_Gene	Hydrolase_Gene	HDAC5 Gene|HD5|HDAC5|Histone Deacetylase 5 Gene|KIAA0600|NY-CO-9	The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Overexpression inhibits cell growth and induces apoptosis in tumor cell lines. (from LocusLink and Cancer Res 2002;62:2913-22)
C24467	HGF_Gene	Growth_Factor_Gene	HGF Gene|HGF|HPTA|Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor) Gene|SF	Human Hepatocyte Growth Factor is also known as Scatter Factor and Hepatopoeitin A.  HGF is a potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types, including renal tubular epithelial cells, epidermal keratinocytes and melanocytes.  A single chain precursor is cleaved to 70 kD and 30kD chains that are linked by one disulfide bond. Both the single chain and cleaved form are active.
C24468	HGS_Gene	Signaling_Pathway_Gene	HGS Gene|HGS|HRS|Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate Gene	HGS encodes hepatocyte growth factor-regulated tyrosine kinase substrate that is a downstream signaling molecule.  It undergoes tyrosine phosphorylation in response to IL2, CSF2, or HGF.
C24469	HHCM_Gene	Gene_with_Unknown_or_Unclassified_Function	HHCM Gene|HHC(M)|HHCM|Mahlavu Hepatocellular Carcinoma Gene	The 1.4-kb human HHCM Gene at 8q24.3 encodes 467-amino acid 52-kD Hepatocellular Carcinoma Protein HHCM, which appears to have transforming ability on fibroblasts and liver cells. (from LocusLink, Swiss-Prot, and NCI)
C24470	HK2_Gene	Phosphotransferase_Gene	HK2 Gene|HK2|HKII|HXK2|Hexokinase 2 Gene	Expressed in heart, skeletal muscle, and adipose tissue, 58-kb insulin-responsive human HK2 Gene (Hexokinase Family) at 2p13 encodes outer mitochondrial membrane bound 917-amino acid 102-kD monomeric Hexokinase 2; expression supports glycolysis in rapid cancers. p53 regulation may link glycolysis to cell cycle control. Containing many TF motifs, mouse Hk2 produces a 5.5-kb mRNA from 18 exons. TIS and polyadenylation sites resemble rat and human. Polymorphic HK2 CA-repeat and TA-repeat regions exist. HK2 contains glucose- and ATP-binding sites and a hexokinase domain. The C-terminus contains catalytic activity; membrane binding and regulation associate with the N-terminus. Allosterically regulated by product, HK2 converts aldo-/keto-hexoses to hexose-6-phosphate, the first step of many metabolic pathways. Mutations appear not to contribute to NIDDM. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24471	HM74_Gene	G_Protein-Coupled_Receptor_Gene	GPR109B Gene|G Protein-Coupled Receptor 109B Gene|GPR109B|HM74|PUMAG	Expressing a 2-kb transcript in adipose tissue, neutrophils, and peripheral blood mononuclear cells, the 2-kb human HM74 Gene (GPCR1 Family, Rhodopsin Family) at 12q24.31 encodes Chemokine Receptor HM74, a 387-amino acid 44.5-kD putative G protein-coupled receptor integral membrane protein containing a 7-transmembrane receptor domain and similar to the GPR31 orphan receptor, the B2 bradykinin receptor (BDKRB2), and the thrombin receptor (F2R). HM74 Protein appears to be a nicotinic acid receptor. Binding of nicotinic acid to the mouse ortholog PUMA-G, or to HM74, results in a G protein-mediated decrease in cAMP levels. PUMA-G mediates the anti-lipolytic, lipid-lowering effects of nicotinic acid. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24472	HNRPA3_Gene	Gene_with_Unknown_or_Unclassified_Function	HNRPA3 Gene|D10S102|FBRNP|HNRPA3|Heterogeneous Nuclear Ribonucleoprotein A3 Gene|hnRNPA3	Tightly linked to MEN2, the 3-kb human HNRPA3 Gene at 10q11.1 encodes Heterogeneous Nuclear Ribonucleoprotein A3, a putative 379-amino acid 40-kD nuclear protein similar to heterogeneous ribonucleoproteins, putative components of ribonucleosomes, and to rat helix destabilizing, heterogeneous nuclear ribonucleoprotein A1 (HNRPA1). Containing two RNA recognition motifs (RRM), HNRPA3 belongs to the HNRNP A/B group of basic, GLY-rich proteins. Defects in this gene may cause multiple endocrine neoplasia IIA. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24473	HOXA10_Gene	Homeobox_Gene	HOXA10 Gene|HOX1.8|HOX1H|HOXA10|Homeo Box A10 Gene|Homeobox 1H|Homeobox A10|MGC12859|PL	Human HOXA10 Gene (ABD-B Family) at 7p15-p14.2 resides within the 90-kb HOXA cluster of eight tandem homeobox genes. Encoding 496- and 494-amino acid 41-kD inhibitory DNA-binding Homeobox Protein A10 transcription factors, alternatively spliced 2.2- (isoform B) and 3.0- (isoform A) kb transcripts link differing 5-prime regions to a common 3-prime homeobox domain. Expressed spatially/temporally in posterior domains during genitourinary development, HOXA10 may regulate morphogenesis and differentiation by providing anterior-posterior positional identity. Stimulated by estrogen or progesterone, HOXA10 is expressed in adult endometrium during early pregnancy. Bound to 5-prime AA[AT]TTTTATTAC 3-prime DNA, HOXA10 may mediate progesterone regulation of uterine EP3 and EP4. HOXA10 also appears to regulate hematopoietic lineage commitment. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24474	HOXA9_Gene	Homeobox_Gene	HOXA9 Gene|ABD-B|HOX1.7|HOX1G|HOXA9|Homeobox A9 Gene|MGC1934	Human HOXA9 Gene (ABD-B Family) at 7p15-p14.2 resides within the 90-kb HOXA cluster of eight tandem homeobox genes and encodes 272-amino acid 30-kD Homeobox Protein A9 isoforms, class I sequence-specific DNA-binding homeobox transcription factors potentially involved in morphogenesis and myeloid differentiation; expression is spatially and temporally regulated during embryonic development. Frameshifted transcript variant 2 encodes isoform B containing a distinct C-terminus that lacks the homeodomain. HOXA9 acts within a developmental regulatory system that provides specific anterior-posterior positional identities to cells. Associated with acute myeloid leukemogenesis, t(7;11)(p15;p15) fuses the nucleoporin NUP98 amino terminal half in-frame to HOXA9, which may inhibit differentiation or disrupt nucleocytoplasmic transport. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24475	HOXC6_Gene	Homeobox_Gene	HOXC6 Gene|CP25|HHO.C8|HOX3|HOX3C|HOXC6|Homeo Box C6 Gene	The 14-kb human HOXC6 Gene (ANTP Family) at 12q13.3 resides within the HOXC cluster of tandem homeobox genes encoding highly conserved sequence-specific DNA-binding transcription factors. HOXC5, HOXC4, and HOXC6 are co-transcribed to a primary transcript; some processed transcripts share the 5' non-coding exon. HOXC6 variant 2 transcripts contain a distinct 5' UTR lacking part of an in-frame 5' coding region. The 2.2- and 1.8-kb transcripts encode 153- and 235-amino acid (27-kD) transcription repressors that can cooperate with other HOX proteins and may contribute to the breast cell phenotype through co-operative interactions. As part of a developmental regulatory system that provides anterior-posterior positional identity to cells, Homeobox C6 Protein may regulate the coordinated expression of multiple genes involved in morphogenesis and differentiation. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24476	HPCA_Gene	Signaling_Pathway_Gene	HPCA Gene|BDR2|HPCA|Hippocalcin Gene	The 8.7-kb human HPCA Gene (Recoverin Subfamily) at 1p35-p34.2 expresses a single 2-kb neuron-specific transcript that encodes 192-amino acid 22-kD myristoylated plasma membrane-associated Hippocalcin, which binds two Ca(2+) ions and contains the EF-hand Ca(2+)-binding motif. Human sequence shows complete amino acid identity and 92% nucleotide identity with rat; it is also identical to mouse hippocalcin protein. Hippocalcin shows striking similarity to photoreceptor Ca(2+)-sensitive proteins that regulate photosignal transduction. Hippocalcin displays recoverin activity and a calcium-dependent inhibition of rhodopsin kinase; it may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24477	HPSE_Gene	Hydrolase_Gene	HPSE Gene|HPA|HPR1|HPSE|HPSE1|HSE1|Heparanase Gene	The single copy 43-kb human HPSE Gene at 4q21.3 contains twelve exons expressed as a ubiquitous 4-kb transcript, and as a 2-kb transcript in placenta, peripheral blood leukocytes, spleen, lymph node, bone marrow, fetal liver, and thymus. With hydrophobic stretches suggesting a transmembrane protein and six potential N-glycosylation sites, 543-amino acid Heparanase is an endoglycosidase (beta-glucuronidase) that degrades heparan sulfate and related proteoglycans in the ECM and vascular basal laminar. Heparan sulfate degradation is key in tumor cell and migrating leukocyte extravasation. Heparanase activity is also important in angiogenesis, wound healing, and smooth muscle proliferation. (from LocusLink, OMIM, and NCI)
C24478	HSD17B7_Gene	Oxidoreductase_Gene	HSD17B7 Gene|HSD17B7|Hydroxysteroid (17-beta) Dehydrogenase 7 Gene|PRAP	Expressed in breast, ovaries, pregnant uterus, placenta, testis, thymus, prostate, fetal liver, and some neural tissues, the 22-kb human HSD17B7 Gene (SDR Family) at 1q23 contains nine exons that produce two alternative isoforms, which encode 341-amino acid 38-kD 17-Beta-Hydroxysteroid Dehydrogenase 7. Lymphoid- and brain-specific promoter transcription factor-binding sites exist. Nearly 75% identical to rodent proteins and containing a short chain dehydrogenase domain, the membrane-associated and phosphorylated enzyme oxidizes or reduces estrogens and androgens; it is responsible for biosynthesis of estradiol in the corpus luteum during pregnancy. HSD17B7 contains a 28-residue insert close to the transmembrane domain that forms a superficial loop, a candidate prolactin receptor (PRLR)-binding domain. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24479	HTATIP2_Gene	Apoptosis_Promoter_Gene|Transcription_Coactivator_Gene	HTATIP2 Gene|CC3|HIV-1 Tat Interactive Protein 2, 30kDa Gene|HTATIP2|TIP30	The 20-kb human tumor suppressor HTATIP2 Gene (SDR Family) at 11p15.1 generates a ubiquitous 1.6-kb transcript that encodes conserved 242-amino acid 30-kD nuclear and membrane-associated TAT-Interacting Protein TIP30. TIP30 contains several conserved features: a semialdehyde dehydrogenase domain, a N-terminal beta-alpha-beta fold that may bind NADP(H), and a unique 20-amino acid N-terminal alpha helix that may enable protein docking. TIP30 proapoptotic activity resides in the N-terminal domain. A 0.8-kb splice variant encodes membrane-associated 133-amino acid TC3 protein with a short, unique C-terminus that confers antiapoptotic properties. TIP30 appears to be a RNA polymerase II transcription co-activator and may function as a co-activator for HIV-1 TAT protein. TIP30 may also suppress metastasis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24480	IFITM1_Gene	Protein_Complex_Subunit_Gene|Transmembrane_Protein_Gene	IFITM1 Gene|IFI17|IFITM1|Interferon Induced Transmembrane Protein 1 (9-27) Gene|LEU13	Controlled by IFN-alpha and -gamma, the two-exon human IFITM1 Gene (IFN-Induced Transmembrane Protein Family) on chromosome 11 encodes 125-amino acid 14-kD Interferon-Induced Transmembrane Protein 1 (Fragilis), a membrane protein component of a multimeric complex involved in transduction of antiproliferative and homotypic adhesion signals. Fragilis appears to demarcate germ cells from somatic neighbors and mark the onset of germ cell competence. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24481	IFNA13_Gene	Signaling_Pathway_Gene	IFNA13 Gene|IFNA1|IFNA13|Interferon, Alpha 13 Gene	Situated in a cluster of interferon-alpha and -omega genes and expressed by macrophages, the 0.65 kb human IFNA13 Gene (IFN Alpha Family) at 9p22 encodes a secreted 189-amino acid 21.7 kD Interferon Alpha 13 precursor containing the interferon alpha/beta domain. With telomeric 3-prime ends, the interferon genes exhibit the order: pter-IFNB1-(IFNW1, IFNA21)-IFNWP15-IFNA4-IFNW9-IFNA7-IFNA10-IFNWP18-IFNAP16-IFNA17-IFNA14-(IFNA22, IFNA5, IFNAP20, IFNA6, IFNA13, IFNA2)-(IFNA8, IFNW2, IFNWP19, IFNA1)-MTAP-cen. Interferon Alpha 13 appears to regulate antiviral defense, cell growth, and immune activation; it stimulates the production of a protein kinase and an oligoadenylate synthetase. Interferons Alpha-13 and Alpha-1 have identical protein sequence. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24482	IFNA2_Gene	Signaling_Pathway_Gene	IFNA2 Gene|IFNA2|Interferon, Alpha 2 Gene	Situated in a cluster of interferon-alpha and -omega genes and expressed by macrophages, the 1.1 kb human INFA2 Gene (IFN Alpha Family) at 9p22 generates Alpha-2A, Alpha-2B, and Alpha-2C isoforms that encode a secreted 188-amino acid 21.6 kD Interferon Alpha 2 precursor containing the interferon alpha/beta domain. With telomeric 3-prime ends, the interferon genes exhibit the order: pter-IFNB1-(IFNW1, IFNA21)-IFNWP15-IFNA4-IFNW9-IFNA7-IFNA10-IFNWP18-IFNAP16-IFNA17-IFNA14-(IFNA22, IFNA5, IFNAP20, IFNA6, IFNA13, IFNA2)-(IFNA8, IFNW2, IFNWP19, IFNA1)-MTAP-cen. Exhibiting interferon-alpha/beta receptor ligand activity, Interferon Alpha-2 appears to regulate antiviral defense, cell growth, and immune activation; it stimulates the production of a protein kinase and an oligoadenylate synthetase. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24483	IFNW1_Gene	Signaling_Pathway_Gene	IFNW1 Gene|IFNW1|Interferon, Omega 1 Gene	Situated in a cluster of interferon-alpha and -omega genes, the 1.5 kb human IFNW1 Gene (IFN Alpha, Beta, Delta Family) at 9p21-p22 encodes a secreted 195-amino acid 22 kD Interferon Omega 1 precursor, a type I interferon protein containing the interferon alpha/beta domain. With telomeric 3-prime ends, the interferon genes exhibit the order: pter-IFNB1-(IFNW1, IFNA21)-IFNWP15-IFNA4-IFNW9-IFNA7-IFNA10-IFNWP18-IFNAP16-IFNA17-IFNA14-(IFNA22, IFNA5, IFNAP20, IFNA6, IFNA13, IFNA2)-(IFNA8, IFNW2, IFNWP19, IFNA1)-MTAP-cen. Interferon Omega-1 appears to regulate antiviral defense, cell growth, and immune activation. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24484	IGBP1_Gene	Ligand_Binding_Protein_Gene	IGBP1 Gene|IGBP1|Immunoglobulin (CD79A) Binding Protein 1 Gene	Ubiquitously expressed as a 1.4-kb mRNA (highest in heart, skeletal muscle, and pancreas), human IGBP1 Gene at Xq13.1-q13.3 encodes 339-aa 39-kDa Immunoglobulin Binding Protein 1, likely involved in IgM/B-Cell Receptor signal transduction. Similar to mouse Igbp1 and yeast TAP42, IGBP1 contains potential N-glycosylation sites, myristylation sites, multiple potential PKC and casein kinase II phosphorylation sites, and an SH3-binding sequence-related stretch. IGBP1 associates with and likely regulates the activity of Ser/Thr phosphatase PP2A-Alpha and PP2A-Beta catalytic subunits. IGBP1 also associates with PP4 and PP6. (NCI)
C24485	IGF1_Gene	Growth_Factor_Gene	IGF1 Gene|IGF1|IGFI|Insulin-Like Growth Factor 1 (Somatomedin C) Gene	Encodes Insulin-like growth factor I (somatomedin C); activates cell proliferation and differentiation
C24486	IGF2_Gene	Growth_Factor_Gene	IGF2 Gene|IGF2|Insulin-Like Growth Factor 2 (Somatomedin A) Gene	Insulin-like growth factors I and II, also known as somatomedin C and somatomedin A, respectively, are single chain polypeptides which share an amino acid sequence homology of about 47% with insulin and about 31% with relaxin and with them comprise the insulin family of polypeptide growth factors. Their functions include mediation of growth hormone action, stimulation of growth of cultured cells, stimulation of the action of insulin, and involvement in development and growth. They appear to be autocrine regulators of cell proliferation.
C24487	IGF2R_Gene	Growth_Factor_Receptor_Gene	IGF2R Gene|CD222|CIMPR|IGF2R|Insulin-Like Growth Factor 2 Receptor Gene|M6P-R|MPRI	Encodes IGF2R, a 250kDa transmembrane protein. It was originally identified as a receptor for IGFII and M6P-containing proteins (e.g. lysosomal hydrolases). Lysosomal enzymes are sorted to lysosomes via IGF2R either from the Golgi, where the enzymes acquire M6P, or from the extracellular space. The majority of IGF2R molecules are located intracellularly, only 5-10% is present on the cell membrane. IGF2R is also a receptor for TGFbeta latency associated peptide (LAP), proliferin and may bind several molecules independently of M6P, including plasminogen, CD87 or retinoic acid. It is involved in activation of latent TGFbeta.  It is a putative hepatocellular tumor suppressor. (from LocusLink)
C24488	IGFBP3_Gene	Transport_Protein_Gene	IGFBP3 Gene|IBP3|IGFBP3|Insulin-Like Growth Factor Binding Protein 3 Gene	The insulin-like growth factors, their receptors, and their binding proteins play key roles in regulating cell proliferation and apoptosis. Among the several roles of IGFBP3 are its function as the major carrying protein for IGF1 and IGF2 in the circulation, and its action as a modulator of IGF bioactivity and as a direct growth inhibitor in the extravascular tissue compartment, where it is expressed in a highly regulated manner (LocusLink)
C24489	IGFBP4_Gene	Transport_Protein_Gene	IGFBP4 Gene|IBP4|IGFBP4|Insulin-Like Growth Factor Binding Protein 4 Gene	The insulin-like growth factors, their receptors, and their binding proteins play key roles in regulating cell proliferation and apoptosis. IGFBP4 functions as a carrying protein for IGF1 and IGF2 in the circulation, and it acts as an inhibitor of IGF action in tissues. (from LocusLink)
C24490	IGFBP5_Gene	Transport_Protein_Gene	IGFBP5 Gene|IBP5|IGFBP5|Insulin-Like Growth Factor Binding Protein 5 Gene	The insulin-like growth factors, their receptors, and their binding proteins play key roles in regulating cell proliferation and apoptosis. IGFBP5 may function as a carrying protein for IGF1 and IGF2 in the circulation and it can act as an inhibitor of IGF action.
C24491	IGFBP6_Gene	Transport_Protein_Gene	IGFBP6 Gene|CD130|CDw130|GP130|GP130-RAPS|IBP6|IGFBP6|IL6R-beta	The insulin-like growth factors, their receptors, and their binding proteins play key roles in regulating cell proliferation and apoptosis. Acts as a cell density and Ca+2 dependent inhibitor of cell growth. (LocusLink)
C24492	IL10RB_Gene	Cytokine_Receptor_Gene	IL10RB Gene|CRF2-4|CRFB4|IL-10R2|IL10RB|Interleukin 10 Receptor, Beta Gene	The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction.
C24493	IL11RA_Gene	Cytokine_Receptor_Gene	IL11RA Gene|IL11RA|Interleukin 11 Receptor, Alpha Gene|MGC2146	This gene encodes the alpha subunit of the high-affinity receptor for interleukin-11. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. (LocusLink)
C24494	IL12A_Gene	Protein_Complex_Subunit_Gene	IL12A Gene|CLMF|IL-12A|IL12A|Interleukin 12A (Natural Killer Cell Stimulatory Factor 1, Cytotoxic Lymphocyte Maturation Factor 1, P35) Gene|NFSK|NKSF1	IL12A (p35) comprises one chain of the heterodimeric IL12. Interleukin-12 is a novel cytokine cloned from B-cell lines. It has a broad array of potent biologic activities, acting at picomolar and subpicomolar levels on both T and NK cells. It stimulates the production of interferon gamma from T-cells and natural killer cells and also induces differentiation of TH1 cells. Sequence comparisons showed that p35 is related in sequence to ligands of the cytokine receptor family, most closely to IL6 and GCSF. On the other hand, p40 is a member of the cytokine receptor family, most closely related to IL6R, and forms a subgroup with IL6R and GCSFR. (from OMIM 161560)
C24495	IL12B_Gene	Protein_Complex_Subunit_Gene	IL12B Gene|CLMF|CLMF2|IL-12B|IL12B|Interleukin 12B (Natural Killer Cell Stimulatory Factor 2, Cytotoxic Lymphocyte Maturation Factor 2, P40) Gene|NKSF2	IL12B (p40) comprises one chain of the heterodimeric IL12. Interleukin-12 is a novel cytokine cloned from B-cell lines. It has a broad array of potent biologic activities, acting at picomolar and subpicomolar levels on both T and NK cells. It stimulates the production of interferon gamma from T-cells and natural killer cells and also induces differentiation of TH1 cells. Sequence comparisons showed that p40 is a member of the cytokine receptor family, most closely related to IL6R, and forms a subgroup with IL6R and GCSFR. On the other hand, p35 is related in sequence to ligands of the cytokine receptor family, most closely to IL6 and GCSF. (from OMIM 161560)
C24496	IL13_Gene	Interleukin_Gene	IL13 Gene|IL-13 Gene|IL13|Interleukin 13 Gene|Interleukin 13 Precursor Gene|NC30 Gene|P600 Gene	The IL13 gene at 5q31 encodes Interleukin-13, which is an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. Interleukin-13 is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. (From LocusLink)
C24497	IL17C_Gene	Interleukin_Gene	IL17C Gene|IL17C|Interleukin 17C Gene	Expressed by activated T cells, human IL17C Gene (IL-17 Family) at 16q24 encodes 197-aa 22-kDa (precursor) secreted cytokine Interleukin-17C (IL17-related), which may stimulate release of TNF-alpha and IL-1beta from monocytes in inflammatory immune responses. IL17C differs from IL17 in its pattern of expression, biologic activity, and lack of interaction with IL17 receptor. (NCI)
C24498	IL2_Gene	Interleukin_Gene	IL2 Gene|Aldesleukin Gene|IL-2 Gene|IL2|Interleukin 2 Gene|Interleukin 2 Precursor Gene|T Cell Growth Factor Gene|T-Cell Growth Factor Gene|TCGF Gene	The IL2 gene at 4q26-q27 encodes Interleukin-2, which is a secreted cytokine that is important for the proliferation of T and B lymphocytes. The receptor of this cytokine is a heterotrimeric protein complex whose gamma chain is also shared by interleukin 4 (IL4) and interleukin 7 (IL7). The expression of this gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a similar gene in mice leads to ulcerative colitis-like disease, which suggests an essential role of this gene in the immune response to antigenic stimuli.  (From LocusLink)
C24499	IL2RB_Gene	Cytokine_Receptor_Gene	IL2RB Gene|CD122|IL2RB|Interleukin 2 Receptor, Beta Gene|P70-75	The protein encoded by this gene represents the beta subunit of the interleukin 2 receptor and is a type I membrane protein. It is involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. It plays a role in the T cell mediated immune response and is a member of the cytokine receptor family. (from LocusLink)
C24500	IL2RG_Gene	Cytokine_Receptor_Gene	IL2RG Gene|CD132|IL2RG|IMD4|Interleukin 2 Receptor, Gamma (Severe Combined Immunodeficiency) Gene|SCIDX|SCIDX1	This gene encodes interleukin 2 receptor gamma chain (IL2RG), which is an important signalling component of many interleukin receptors (IL2,IL4,IL7,IL9, and IL15), is thus referred to as the common gamma chain. It is necessary for normal growth and differentiation of T cells, B cells, natural killer cells, glioma cells, and cells of the monocyte lineage.  Mutations in this X-chromosome-linked gene cause X-linked severe combined immunodeficiency (XSCID). (from LocusLink and OMIM)
C24501	IL4R_Gene	Cytokine_Receptor_Gene	IL4R Gene|CD124|IL4R|IL4RA|Interleukin 4 Receptor Gene	IL4R when complexed with the common gamma chain (IL2RG) serves as the high-affinity interleukin 4 (IL4) receptor. It plays a major role in immunoglobulin E (IgE) production
C24502	IL5_Gene	Interleukin_Gene	IL5 Gene|B Cell Differentiation Factor I Gene|EDF Gene|Eosinophil Differentiation Factor Gene|IL-5 Gene|IL5|Interleukin 5 (Colony-Stimulating Factor, Eosinophil) Gene|Interleukin 5 Precursor Gene|Interleukin-5 Gene|T-Cell Replacing Factor Gene|TRF Gene	The IL5 Gene at 5q31.1 encodes Interleukin-5, which is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. (From LocusLink)
C24503	IL5RA_Gene	Cytokine_Receptor_Gene	IL5RA Gene|CD125|CDw125|HSIL5R3|IL5R|IL5RA|Interleukin 5 Receptor, Alpha Gene|MGC26560	The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported.
C24504	IL6_Gene	Interleukin_Gene	IL6 Gene|B-Cell Differentiation Factor Gene|B-Cell Stimulatory Factor 2 Gene|BSF-2 Gene|BSF2 Gene|HGF Gene|HSF Gene|Hepatocyte Stimulatory Factor Gene|Hybridoma Growth Factor Gene|IFNB2 Gene|IL-6 Gene|IL6|Interferon Beta-2 Gene|Interferon, Beta-2 Gene|Interleukin 6 (Interferon, Beta 2) Gene|Interleukin-6 Gene	The IL6 Gene at 7p21 encodes Interleukin-6, which is a cytokine with a wide variety of biological functions. Interleukin-6 plays an essential role in the final differentiation of B-cells into Ig-secreting cells. It induces myeloma and plasmacytoma growth as well as nerve cells differentiation. In hepatocytes it induces acute phase reactants. (From Swiss-Prot)
C24505	IL6ST_Gene	Signaling_Pathway_Gene	IL6ST Gene|CD130|CDw130|GP130|GP130-RAPS|IL6R-beta|IL6ST|Interleukin 6 Signal Transducer (GP130, Oncostatin M Receptor) Gene	Widely expressed (not restricted to IL6 responsive cells) human IL6ST Gene (Type I Cytokine Receptor 2 Family) encodes heterodimeric type I membrane protein (isoform 1) and secreted (isoform 2) Interleukin 6 Signal Transducer, containing 5 fibronectin type III domains, an Ig-like C2-type domain, a BOX 1 motif required for JAK interaction/activation, and a WSXWS motif necessary for protein folding, intracellular transport, and cell-surface receptor binding. Part of cytokine receptor complexes, IL6ST is a signal transducer dependent on receptor binding for activation by many cytokines (IL6, CNTF, LIF, IL11, CT1, and OSM) that can utilize gp130 in signal transmission. IL6ST may regulate myocyte apoptosis and have a role in embryonic development. Isoform 2 is an autoantigen in rheumatoid arthritis but it is not specific to RA. (NCI)
C24506	IL7R_Gene	Cytokine_Receptor_Gene	IL7R Gene|CD127|CDW127|IL-7R-alpha|IL7R|Interleukin 7 Receptor Gene	The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor common gamma chain (IL2RG). This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). (from LocusLink)
C24507	IL8_Gene	Interleukin_Gene	IL8 Gene|3-10C|AMCF-I|CXCL8|GCP-1|GCP1|IL-8|IL8|Interleukin 8 Gene|K60|LECT|LUCT|LYNAP|MDNCF|MONAP|NAF|NAP-1|NAP1|SCYB8|TSG-1|b-ENAP	The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. (from LocusLink)
C24508	IL8RA_Gene	Cytokine_Receptor_Gene	IL8RA Gene|C-C-CKR-1|CDw128a|CMKAR1|CXCR1|IL8R1|IL8RA|IL8RBA|Interleukin 8 Receptor, Alpha Gene	Interleukin-8 is a member of a family of pro-inflammatory cytokines. The best-characterized activities of IL8 include the chemoattraction and activation of neutrophils. There are two IL8 receptors, type 1 (alpha) and type 2 (beta). The type 1 IL8 receptor binds only IL8, while the type 2 IL8 receptor binds also GRO and NAP-2. (from OMIM)
C24509	IL8RB_Gene	Cytokine_Receptor_Gene	IL8RB Gene|CDw128b|CMKAR2|CXCR2|IL8R2|IL8RB|Interleukin 8 Receptor, Beta Gene	Interleukin-8 is a member of a family of pro-inflammatory cytokines. The best-characterized activities of IL8 include the chemoattraction and activation of neutrophils. There are two IL8 receptors, type 1 (alpha) and type 2 (beta). The type 1 IL8 receptor binds only IL8, while the type 2 IL8 receptor binds also GRO and NAP-2. (from OMIM)
C24510	ILK_Gene	Signaling_Pathway_Gene	ILK Gene|ILK|Integrin-Linked Kinase Gene|P59	ILK encodes a predicted 451-amino acid protein, with an apparent molecular weight of 59 kD. The ILK protein is a serine/threonine protein kinase with 4 ankyrin-like repeats. ILK regulates integrin-mediated signal transduction. Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. (LocusLink)
C24511	ING1_Gene	Regulatory_Gene	ING1 Gene|ING1|Inhibitor of Growth Family, Member 1 Gene|p33ING1	The protein product of the ING1 gene physically interacts with p53 and appears necessary for the role of p53 in growth inhibition/apoptosis. ING1 shares many biological functions with p53 and has been reported to mediate growth arrest, senescence, apoptosis, anchorage-dependent growth, chemosensitivity, and DNA repair. Some of these functions, such as cell cycle arrest and apoptosis, have been shown to be dependent on the activity of both ING1 and p53 proteins. (from Leuk Res 2002;26:631-5 and Exp Cell Res 2002;279:291-8)
C24512	INHA_Gene	Protein_Complex_Subunit_Gene	INHA Gene|INHA|Inhibin, Alpha Gene	This gene encodes inhibin alpha subunit that can joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. (LocusLink)
C24513	INHBA_Gene	Protein_Complex_Subunit_Gene	INHBA Gene|EDF|FRP|INHBA|Inhibin, Beta A (Activin A, Activin AB Alpha Polypeptide) Gene	Human INHBA Gene at 7p15-p13 encodes the Inhibin Beta A subunit, heterodimerized with the Alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin negatively regulates gonadal stromal cell proliferation, has tumor-suppressor activity, and is a marker for primary as well as recurrent granulosa-cell tumors. Inhibin may be both a growth/differentiation factor and a hormone; gonadal and extragonadal expression can vary severalfold in a tissue-specific fashion. Beta A also forms a homodimer, Activin A, and joins with the Beta B subunit to form heterodimeric Activin AB; Activins stimulate FSH secretion. (NCI)
C24514	INS_Gene	Peptide_Hormone_Gene	INS Gene|INS|Insulin Gene	Expressed by pancreatic islet beta cells, human INS Gene (Insulin Family) encodes a 110-aa 12-kDa proinsulin precursor of secreted Insulin, a heterodimeric protein hormone derived after signal peptide removal from post-translational cleaved of proinsulin into peptide A and peptide B chains covalently linked by disulfide bonds. Binding of mature insulin to INSR stimulates glucose uptake; accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver; increases cell permeability to monosaccharides, amino acids, and fatty acids; regulates protein and lipid metabolism; and decreases blood glucose concentration by moving it into cells to be used for energy. Defects in INS cause familial hyperproinsulinemia. (NCI)
C24515	INSL4_Gene	Peptide_Hormone_Gene	INSL4 Gene|EPIL|INSL4|Insulin-Like 4 (Placenta) Gene	Expressed in fetal perichondrium, uterus, cytotrophoblasts, and syncytiotrophoblasts, 2-exon human INSL4 Gene (Insulin Family) encodes a 139-aa 15-kDa precursor of Insulin-Like Peptide 4, containing 6 consensus half-cystine residues essential for tertiary structure. The precursor undergoes cleavage to produce A/B/C chains that form tertiary structures of all three chains, or just A and B chains. With insulin-like effects in cell growth control that are not mediated by the INSR, INSL4 may play role in trophoblast development, cell proliferation, differentiation, and bone formation. Acting through membrane tyrosine kinase receptors, INSL growth factors are essential for regulation of energy metabolism, proliferation, and differentiation; intracellular signal transduction pathways invoke a chain of phosphorylation-related events. Chorionic gonadotropin production is increased by INSL4. (NCI)
C24516	INSR_Gene	Receptor_Tyrosine_Kinase_Gene	INSR Gene|INSR|Insulin Receptor Gene	After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake.(LocusLink)
C24517	INSRR_Gene	Receptor_Tyrosine_Kinase_Gene	INSRR Gene|INSRR|IRR|Insulin Receptor-Related Receptor Gene	Human INSRR Gene (Insulin Receptor Family) encodes 1297-aa 144-kDa (precursor) Insulin Receptor-Related Receptor, a type I membrane protein containing 4 fibronectin type III domains, a probable tetramer of disulfide-linked alpha and beta chains, and structurally similar to INSR and IGF1R. The two alpha chains contribute to formation of the ligand-binding domain for an insulin related protein; the two beta chains carry the tyrosine kinase domain. INSRR phosphorylates insulin receptor substrates IRS-1 and IRS-2. (NCI)
C24518	IRAK1_Gene	Serine-Threonine_Protein_Kinase_Gene	IRAK1 Gene|IRAK|IRAK1|Interleukin-1 Receptor-Associated Kinase 1 Gene|pelle	IRAK1 encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK1 is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. (from LocusLink)
C24519	IRAK3_Gene	Signaling_Pathway_Gene	IRAK3 Gene|IRAK-M|IRAK3|Interleukin-1 Receptor-Associated Kinase 3 Gene	Expressed in peripheral leukocytes and monocytes, human IRAK3 Gene at 12q14.1 encodes 596-aa Interleukin-1 Receptor-Associated Kinase 3, containing an N-terminal death domain and central kinase domain. IRAK3 appears to activate NF-kappa-B via IL1R. IRAK3 interacts with MYD88 and TRAF6 signaling proteins in a manner similar to the other IRAKs. It prevents dissociation of IRAK and IRAK4 from MYD88 and formation of IRAK/TRAF6 complexes. But IRAK3 does not autophosphorylate in the manner of IRAK1. IRAK1, -2, and -3 mediate the TLR2-dependent response to lipopolysaccharide. IRAK3 is induced upon TLR stimulation and negatively regulates TLR signaling. (NCI)
C24520	IRF1_Gene	Transcription_Coactivator_Gene	IRF1 Gene|IRF-1|IRF1|Interferon Regulatory Factor 1 Gene|MAR	IRF1 encodes interferon regulatory factor 1, a member of the interferon regulatory transcription factor (IRF) family. IRF1 serves as an activator of interferons alpha and beta transcription, and in mouse it has been shown to be required for double-stranded RNA induction of these genes. IRF1 also functions as a transcription activator of genes induced by interferons alpha, beta, and gamma. Further, IRF1 has been shown to play roles in regulating apoptosis and tumor-suppression. (from LocusLink)
C24521	IRF2_Gene	Transcription_Coactivator_Gene	IRF2 Gene|IRF-2|IRF2|Interferon Regulatory Factor 2 Gene	IRF2 encodes interferon regulatory factor 2, a member of the interferon regulatory transcription factor (IRF) family. IRF2 competitively inhibits the IRF1-mediated transcriptional activation of interferons alpha and beta, and presumably other genes that employ IRF1 for transcription activation. However, IRF2 also functions as a transcriptional activator of histone H4. (from LocusLink)
C24522	IRS1_Gene	Adaptor_Signaling_Protein_Gene	IRS1 Gene|HIRS-1|IRS1|Insulin Receptor Substrate 1 Gene	The gene encodes a substrate for insulin receptor.  It acts as an interface between signaling proteins with Src homology-2 domains (SH2 proteins) and the receptors for insulin, IGF2, growth hormone, several interleukins (IL4, IL9, IL13), and other cytokines. It regulates gene expression and stimulates mitogenesis and appears to mediate insulin/IGF1-stimulated glucose transport. (from OMIM 600797)
C24523	IRS2_Gene	Adaptor_Signaling_Protein_Gene	IRS2 Gene|IRS2|Insulin Receptor Substrate 1 Gene	IRS2 encodes the insulin receptor substrate 2, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS2 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS2 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin-4 receptor (IL4R) -associated kinase in response to IL4 treatment. (LocusLink)
C24524	IRS4_Gene	Adaptor_Signaling_Protein_Gene	IRS4 Gene|IRS-4|IRS4|Insulin Receptor Substrate 4 Gene|PY160	IRS4 encodes the insulin receptor substrate 4, a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. (LocusLink)
C24525	ITGB4_Gene	Cell_Adhesion_Molecule_Gene	ITGB4 Gene|ITGB4|Integrin, Beta 4 Gene	Integrins are transmembrane glycoprotein receptors that mediate cell-matrix or cell-cell adhesion, and transduce signals that regulate gene expression and cell growth. They are heterodimeric molecules consisting of noncovalently linked alpha and beta subunits. All integrin subunits display a cytoplasmic domain that interacts with the cytoskeleton, a transmembrane region, and a large extracellular domain that interacts with the extracellular matrix. The ITGB4 extracellular domain shows 35% identify with other integrin beta subunits, but is the most different among this class of molecules. The transmembrane region is poorly conserved, whereas the cytoplasmic domain showed no substantial identity in any region to the cytoplasmic tails of other integrin beta sequences or to other protein sequences. The integrin alpha-6/beta-4, a receptor for the laminins, is likely to play a pivotal role in the biology of invasive carcinoma. (from OMIM)
C24526	ITK_Gene	Non-Receptor_Tyrosine_Kinase_Gene	ITK Gene|EMT|IL2-Inducible T-Cell Kinase Gene|ITK|LYK|PSCTK2	Induced in T-cells and natural killer cells by interleukin-2, ITK Gene (TEC Tyr Kinase Family) at 5q31-q32 encodes 620-aa 72-kDa intracellular IL2-Inducible T-Cell (tyrosine) Kinase, containing an SH2, SH3, and PH domain, which appears to localize to cell surface receptors (TCR,CD28, CD2) after stimulation and plays a role in T-cell proliferation and differentiation. (NCI)
C24527	ITPR1_Gene	Receptor_Gene	ITPR1 Gene|IP3R|IP3R1|ITPR1|Inositol 1,4,5-Triphosphate Receptor, Type 1 Gene|Insp3r1	Widely expressed, human ITPR1 Gene (InsP3R Family) at 3p26-p25 encodes 8 potential alternative isoforms of 2758-aa 314-kDa integral endoplasmic reticulum membrane protein Inositol 1,4,5-Triphosphate Receptor Type 1, which mediates release of intracellular calcium in response to second messenger inositol 1,4,5-trisphosphate. A likely homotetramer, the receptor contains 5 MIR domains, a large N-terminal ligand-binding cytoplasmic region, and central modulatory sites immediately upstream of the C-terminal calcium channel. Calcium appears to inhibit ligand binding to the receptor, perhaps by interaction with an inhibitory calcium-binding protein. Phosphorylation may prevent ligand-induced opening of the calcium channel. ITPR1 interacts with TRPC4 and is phosphorylated by c-AMP kinase. (NCI)
C24528	JAK1_Gene	Non-Receptor_Tyrosine_Kinase_Gene	JAK1 Gene|JAK1|JAK1A|Janus Kinase 1 (A Protein Tyrosine Kinase) Gene	The JAK1 gene encodes Janus kinase 1, which is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. (from LocusLink)
C24529	JAK2_Gene	Non-Receptor_Tyrosine_Kinase_Gene	JAK2 Gene|JAK2|Janus Kinase 2 (A Protein Tyrosine Kinase) Gene	This gene encodes a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. (from LocusLink)
C24530	JAK3_Gene	Non-Receptor_Tyrosine_Kinase_Gene	JAK3 Gene|JAK3|JAKL|Janus Kinase 3 (A Protein Tyrosine Kinase, Leukocyte) Gene|LJAK	JAK3 encodes janus kinase 3, a tyrosine kinase that belongs to the janus family. JAK3 functions in signal transduction and interacts with members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations that abrogate janus kinase 3 function cause an autosomal SCID (severe combined immunodeficiency disease). (from LocusLink)
C24531	JTB_Gene	Transmembrane_Protein_Gene	JTB Gene|B PAR|BPAR|HJTB|JTB|Jumping Translocation Breakpoint Gene|PAR|hJT	Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. The JTB gene (jumping translocation breakpoint) at 1q21 was identified. It is found fused with the telomeric repeats of acceptor telomeres in a case of jumping translocation. The JTB open reading frame encodes a 146-amino acid protein with a 75-amino acid extracellular domain, a 21-amino acid transmembrane domain, and a 20-amino acid intracellular domain. The JTB protein is highly conserved among divergent eukaryotic species. Northern blot analysis showed ubiquitous expression of a 1-kb mRNA, with highest expression in thyroid and skeletal muscle. Kidney and spinal cord expressed an additional transcript of approximately 1.4 kb. Jumping translocations have been reported in leukemia patients, in the Ewing family of tumors, in renal clear cell carcinoma, and in liposarcoma. (from OMIM)
C24532	KDR_Gene	Receptor_Tyrosine_Kinase_Gene	KDR Gene|FLK1|KDR|Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase) Gene|VEGFR|VEGFR2	This gene encodes a receptor for VEGF or VEGF-c. It has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. (from SwissProt)
C24533	KLK15_Gene	Protease_Gene	KLK15 Gene|ACO|HSRNASPH|KLK15|Kallikrein 15 Gene	Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. (from LocusLink)
C24534	KLRB1_Gene	Cell_Adhesion_Receptor_Gene	KLRB1 Gene|CD161|KLRB1|Killer Cell Lectin-Like Receptor Subfamily B, Member 1 Gene|NKR|NKR-P1|NKR-P1A|NKRP1A|hNKR-P1A	Expressing a single 0.8-1.3-kb transcript, the 13-kb human KLRB1 Gene (C-Type Lectin Superfamily, NKRP1 Family) at 12p13 is the most distal gene in an NK gene complex, which contains several C-type lectin genes preferentially expressed in NK cells, including CD69, members of the NKG2 family, and CD94 (KLRD1). C-type lectin superfamily genes, including NKRP1 glycoproteins, expressed by NK cells may regulate NK cell function. Present on a subset of natural killer (NK) lymphocytes and on about 25% of peripheral blood T-cells, the type II membrane protein (external C-terminus) NKRP1A Protein contains a 158-amino acid extracellular domain with C-type lectin motifs, a 29-amino acid transmembrane domain, and a 38-amino acid cytoplasmic domain. NKRP1A protein is 46% identical to rat and mouse NKRP1, and 26% identical to human NKG2A. (from LocusLink, OMIM, and NCI)
C24535	KLRD1_Gene	Immunoprotein_Gene|Receptor_Gene	KLRD1 Gene|CD94|KLRD1|Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Gene|Kp43	Preferentially expressed in NK lymphocytes as 0.8-, 1.8-, 3.5-, and 5.5-kb (minor) transcripts initiated from a heterogeneous 60-bp region, 6-exon 8.3-kb human KLRD1 Gene (C-Lectin Family) at 12p13.2-p12.3 resides in an NK gene complex containing C-lectin genes CD69, NKG2 members, and KLRB1 that regulate NK cell function. Alternates CD94-A (179-amino acid, 20.5-kD) and CD94 ALT (148-amino acid) differ with exon 2 sequence. Full-length type II membrane protein (external C-terminus) CD94 Antigen contains a 147-amino acid extracellular domain with C-type lectin motifs, a 26-amino acid transmembrane domain, and a 7-amino acid cytoplasmic domain (absent in CD94 ALT). CD94 forms disulfide-bonded heterodimers with NKG2A, NKG2C, and NKG2E. Nonclassical MHC HLA-E protein ligand binds to CD94/NKG2A, CD94/NKG2B, and CD94/NKG2C NK cell receptors. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24536	KOC1_Gene	Ligand_Binding_Protein_Gene	IMP-3 Gene|IGF-II mRNA-Binding Protein 3 Gene|IMP-3|KOC1|VICKZ3	The 160-kb human KOC1 Gene at 7p11 encodes IGF-II mRNA-Binding Protein 3, which contains a KH domain. The protein binds to the 5-prime UTR of the IGF-II leader 3-prime mRNA and may repress translation of IGF-II during late development. (from LocusLink and NCI)
C24537	KSR_Gene	Serine-Threonine_Protein_Kinase_Gene	KSR Gene|KSR|KSR1|Kinase Suppressor of Ras Gene|RSU2	The 73-kb human KSR Gene (SER/THR PK Family) at 17q11.1 encodes Kinase Suppressor of RAS-1, a positive modulator of RAS-MAP kinase signaling similar to RAS kinase suppressor (Drosophila). Homologs of KSR are also seen in C. elegans and mouse. The predicted 873-amino acid mouse protein contains a kinase domain similar to RAF kinases; human protein is nearly 95% similar to mouse. KSR1 is required for efficient RAS signaling. In unstimulated cells, CTAK1 constitutively associates with KSR1, phosphorylating Ser392 and conferring cytoplasmic sequestration by 14-3-3 binding. In response to growth factor, KSR1 Ser392 phosphorylation falls, allowing KSR1 to localize with activated RAS and RAF1 at the plasma membrane and facilitating phosphorylation required for activation of MEK and MAPK. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24538	LAF4_Gene	Transcription_Factor_Gene	LAF4 Gene|LAF4|Lymphoid Nuclear Protein Related to AF4 Gene	Preferentially expressed in lymphoid tissues (highest in thymus), the 555-kb human LAF4 Gene (LAF4/MLLT2 Family) at 2q11.2-q12 encodes a major 8.5-kb transcript that yields Lymphoid Nuclear Protein 4, a 1227-amino acid 134-kD nuclear DNA-binding transcriptional activator that may function in lymphoid development and oncogenesis. Greatest similarity to MLLT2 occurs in the N-terminal and C-terminal regions. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24539	LAMP3_Gene	Immunoprotein_Gene	LAMP3 Gene|DC-LAMP|DCLAMP|LAMP|LAMP3|Lysosomal-Associated Membrane Protein 3 Gene|TSC403	Expressed in appendix, thymus, lymph node, lung, and spleen, the 41-kb human LAMP3 Gene (LAMP Family) at 3q26.3-q27 encodes a 3.2-kb transcript that produces Lysosomal-Associated Membrane Protein 3, likely involved in antigen processing by lymphoid dendritic cells that capture antigens, differentiate, and induce T-cell responses. Expression increases in mature interdigitating dendritic cells in T-cell areas. A 416-amino acid 70- to 90-kD type I integral membrane protein (larger than predicted, 44-kD), DCLAMP contains N-and O-glycosylation sites, a LAMP domain, a large extracellular domain, a transmembrane domain, and a 10-amino acid cytoplasmic domain containing a conserved GY lysosomal targeting motif. Expression is up regulated in carcinomas of esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid, and parotid tissues. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24540	LAMR1_Gene	Cell_Adhesion_Receptor_Gene|Ribosome_Subunit_Gene	RPSA Gene|37LRP|67LR|LAMBR|LAMR1|LAMR1 Gene|LRP|RPSA|Ribosomal Protein SA Gene|p40	The 5.7-kb human LAMR1 Gene (Non-Integrin Family, S2P Family) at 3p21.3 contains a promoter with 4 Sp1 sites, multiple TSS, and seven exons that yield a 1.2-kb transcript encoding a conserved 295-amino acid 37-kD multifunctional protein with a negative C-terminal segment, amphipathic alpha-helices, and N-glycosylation sites. GNRH2 or GNRH1 trigger transcription. GC-rich intron 1 contains 5 Sp1 sites, intron 3 contains 2 Alu sequences, and intron 4 contains snRNA E2. Multiple retropositional pseudogenes exist; 16-21 copies per human or mouse haploid genome. Identical to 40S Ribosomal Protein SA, the encoded heterodimeric 67-kD Laminin Receptor-1 precursor is involved in translation and cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis. Gene expression in cancer cells correlates with invasive/metastatic phenotype.  (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24541	LATS1_Gene	Regulatory_Gene|Serine-Threonine_Protein_Kinase_Gene	LATS1 Gene|LATS, Large Tumor Suppressor, Homolog 1 (Drosophila) Gene|LATS1|WARTS|WTS	Widely expressed in fetal and adult tissues, the 42-kb putative tumor suppressor human LATS1 Gene (SER/THR PK Family) at 6q24-q25.1 encodes conserved Large Tumor Suppressor Homolog 1, an 1130-amino acid 127-kD Ser/Thr protein kinase cell cycle regulator containing a catalytic domain and an UBA/TS-N domain. The C-terminal kinase domain of human and mouse proteins share 99% identity; human and Drosophila share 74% identity. The kinase domain and N-terminal region interact, suggesting intramolecular regulation. Phosphorylated in a cell cycle-dependent manner (late prophase-metaphase), LATS1 is a negative regulator of CDC2/cyclin A. In early mitosis, it complexes (via the N-terminal region) with the mitotic apparatus cell cycle controller CDC2 kinase; the complex shows reduced H1 histone kinase activity. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24542	LATS2_Gene	Regulatory_Gene|Serine-Threonine_Protein_Kinase_Gene	LATS2 Gene|LATS, Large Tumor Suppressor, Homolog 2 (Drosophila) Gene|LATS2	The 87-kb human LATS2 Gene (SER/THR PK Family) at 13q11-q12 encodes a 5.8-kb transcript that yields a 125-kD nuclear Large Tumor Suppressor Homolog 2 protein, expressed in many tissues; highest expression in heart and skeletal muscle. Testis also expresses a 3.8-kb transcript, which may have a shorter 3-prime untranslated region than the 5.8-kb transcript. A Ser/Thr protein kinase, LATS2 protein contains seven PAPA repeats (dipeptide proline-alanines) that may be involved in protein-protein interactions and a C-terminal kinase domain. Human and mouse proteins are most closely related to LATS1 proteins, followed by Drosophila Lats. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24543	LCP2_Gene	Adaptor_Signaling_Protein_Gene	LCP2 Gene|LCP2|Lymphocyte Cytosolic Protein 2 (SH2 Domain Containing Leukocyte Protein of 76kDa) Gene|SLP-76|SLP76	The 50-kb human LCP2 Gene at 5q33.1-qter is expressed in peripheral leukocytes, spleen, thymus, T-cells, B-cells, and monocytes as a modular 533-amino acid 76-kD Lymphocyte Cytosolic Protein 2 with three domains; a PEST domain and phosphorylatable tyrosine residues in the acidic N-terminus, a GRB2 binding site in the central proline-rich domain, and a C-terminal SH2 domain. As an adaptor/scaffold protein, SLP-76 associates constitutively or inducibly with GRB2 and FYB adapter proteins and with ZAP70 and SYK as a substrate. By supporting receptor-mediated signal transduction, SLP-76 promotes thymic development and T-cell development and activation, as well as mast cell and platelet function. SLP-76 may collect all pre-TCR signals that drive thymocyte development and appears required for separate development of lymphatic vessels from blood vessels. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24544	LEFTB_Gene	Transforming_Growth_Factor-Beta_Family_Gene	LEFTY1 Gene|LEFTB|LEFTB Gene|LEFTY1|LEFTYB|Left-Right Determination Factor 1 Gene	Closely linked to a related pseudogene, the 2.9-kb human LEFTB Gene (TGF-Beta Family) at 1q42.1 is separated by approximately 50-kb from the related LEFTYA gene. Both genes comprise four exons spliced at identical positions and encode strongly similar secreted proteins. Containing a TGF-beta family domain, 366-amino acid 41-kD Left-Right Determination Factor B (preproprotein) undergoes cell-specific alternative processing into three different products. Processing may occur at R-X-X-R sites. LEFTB appears required for left-right determination during early presomite development in mammals. It may serve as a feedback inhibitor to restrict the range of nodal signaling during establishment of the axis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24545	LEPR_Gene	Cytokine_Receptor_Gene	LEPR Gene|DB|LEPR|Leptin Receptor Gene|OBR	Distal to D1S515 (3-4 cM), centromerically transcribed 193-kb human LEPR Gene (gp130 Cytokine Receptor Family) at 1p31 contains 2 intronic microsatellites and 18 coding exons spliced into 5 Leptin Receptor isoforms variously expressed in liver, hypothalamus, heart, small intestine, hematopoietic tissues, choroid plexus, prostate, ovary, lung and kidney. Isoform E may be soluble. Rat and mouse genes express multiple isoforms. The 1165-amino acid 132.5-kD (precursor) type I membrane protein contains 3 fibronectin III-like domains and is TYR phosphorylated; the cytoplasmic domain appears essential for signal transduction. LEPR appears involved in regulation of fat metabolism through hypothalamic effects, angiogenesis, lymphopoiesis, and possibly reproduction. LEPR appears to activate JAK kinase and STAT3, -5, and -6. LEPR malfunction is associated with diabetes and obesity. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24546	LGALS3BP_Gene	Immunoprotein_Gene	LGALS3BP Gene|90K|LGALS3BP|Lectin, Galactoside-Binding, Soluble, 3 Binding Protein Gene|MAC-2-BP|MAC2BP	With the exception of peripheral blood lymphocytes, the 9-kb human LGALS3BP Gene (MSR1 Superfamily) at 17q25 appears to be expressed at high levels in all tissues as a 2.2-kb transcript (highest in gastrointestinal tissues). The 585-amino acid extracellular Galectin 3 Binding Protein contains an N-terminal macrophage scavenger receptor (MSR1) Cys-rich domain and binds LGALS3 via a carbohydrate-specific interaction. MAC2BP is a potent stimulator of host immune defense systems, such as NK and LAK cell cytotoxicity, and can induce IL2 cytokine production. Oncogenic transformation, viral infection, or pathogen invasion enhance MAC2BP production. LGALS3BP is elevated in the serum of cancer and HIV patients. (from LocusLink, OMIM, and NCI)
C24547	LGALS8_Gene	Ligand_Binding_Protein_Gene	LGALS8 Gene|LGALS8|Lectin, Galactoside-Binding, Soluble, 8 (Galectin 8) Gene|PCTA1|PO66-CBP	Constitutively and ubiquitously expressed, 32.6-kb human LGALS8 Gene (S-Lectin Family) at 1q42-q43 contains a TATA box and eight primary exons. With two alternate exons present in splice variants, three isoforms of 1.6-, 2.6-, and 6-kb are produced. Similar to rat Galectin-8 and containing two carbohydrate-binding (recognition) domains (CRDs), 316-amino acid 35.5-kD extracellular Galectin 8 binds to beta galactoside in cell adhesion, cell cycle regulation, inflammation, immunomodulation, apoptosis, and metastasis. Galectin 8 may be involved in activation of various cell types through cross-linkage of cell surface glycoproteins and may be involved in some types of cancer. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24548	LGI1_Gene	Gene_with_Unknown_or_Unclassified_Function	LGI1 Gene|EPT|IB1099|LGI1|Leucine-Rich, Glioma Inactivated 1 Gene	Predominantly expressed in neural tissues, putative tumor suppressor 40.3-kb human LGI1 Gene at 10q24 encodes a predicted 557-amino acid, 64-kD precursor Leucine-Rich Glioma-Inactivated Protein. Alternative splicing of exon 8 appears to vary between brain and skeletal muscle. Mature 60-kD LGI1 protein contains putative extracellular N-terminus and hydrophobic transmembrane segment, as well as leucine-rich repeats (LRR) with conserved cysteine-rich flanking sequences. LGI1 shows high similarity in the LRR domain with transmembrane and extracellular receptors and adhesion proteins. Translocation rearrangements of LGI1 reduce or abrogate expression in several glioblastomas and brain tumors. LGI1 mutations appear responsible for autosomal dominant partial epilepsy with auditory features. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24549	LHX1_Gene	Homeobox_Gene	LHX1 Gene|LHX1|LIM Homeobox 1 Gene|LIM-1|LIM1	Organized like other LHX genes, with five exons (separated by 0.93-2.3-kb introns) and expressed in brain, thymus, and tonsil, the conserved 5.7-kb human LHX1 Gene (LIM/Homeobox Family) at 11p13-p12 encodes 384-404-amino acid 44.5-kD nuclear LIM Homeobox Protein 1, a putative transcriptional regulatory protein containing two CYS-rich zinc ion-binding LIM domains and a DNA-binding homeobox domain. The LIM domains reside in exons 1 and 2, while the homeodomain is split among exons 3 and 4. An intron at the same position occurs in other homeobox genes, suggesting an ancestral intron insertion. LIM1 may regulate the head organizer and control differentiation and development of neural and lymphoid cells. LIM1 and LMX1B appear to control lateral column motor axon dorsal/ventral trajectory in the developing limb. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24550	LHX2_Gene	Homeobox_Gene	LHX2 Gene|HLHX2|LH-2|LH2|LHX2|LIM HOX Gene 2|LIM Homeo Box Gene 2|LIM Homeobox Gene 2	Centromeric to ABL and closely related to 'apterous' (Drosophila), the 21.5-kb human LHX2 Gene (LIM/Homeobox Family) at 9q33-q34.1 encodes 406-amino acid 44-kD nuclear LIM Homeobox Protein 2, a putative transcription factor containing two CYS-rich zinc ion-binding LIM domains and a DNA-binding homeobox domain. LIM2 may control differentiation and development of neural and lymphoid cells. Rodent LH2 is expressed in the central nervous system and in immature B- and T-cells. In the pituitary, mouse Lh2 regulates expression of the pituitary glycoprotein hormone alpha subunit. High expression is observed in chronic myelogenous leukemia (CML). (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24551	LIF_Gene	Cytokine_Gene	LIF Gene|CDF|HILDA|LIF|Leukemia Inhibitory Factor (Cholinergic Differentiation Factor) Gene	Leukemia inhibitory factor is a cytokine that induces macrophage differentiation. Neurotransmitters and neuropeptides, well known for their role in the communication between neurons, are also capable of activating monocytes and macrophages and inducing chemotaxis in immune cells. LIF signals through different receptors and transcription factors. LIF in conjunction with BMP2 acts in synergy on primary fetal neural progenitor cells to induce astrocytes. (LocusLink)
C24552	LIFR_Gene	Cytokine_Receptor_Gene	LIFR Gene|LIFR|Leukemia Inhibitory Factor Receptor Gene	The LIF gene encodes Leukemia Inhibitory Factor (LIF), which is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action is mediated through a high-affinity receptor complex composed of Leukemia Inhibitory Factor Receptor (a low-affinity LIF binding chain) and gp130 (a high-affinity converter subunit). The high-affinity complex also binds oncostatin M, a related cytokine. Both Leukemia Inhibitory Factor Receptor and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. (from OMIM)
C24553	LIMD1_Gene	Ligand_Binding_Protein_Gene	LIMD1 Gene|LIM Domains Containing 1 Gene|LIMD1	The LIMD1 gene encodes LIM Domains Containing 1. LIM domains consist of a cysteine-rich consensus sequence containing two distinct zinc-binding subdomains, which mediate protein-protein interactions. The predicted protein sequence of this gene reveals three LIM domains located at the C-terminal end, which indicates that it belongs to the group 3 of the gene family encoding LIM motifs. This gene is ubiquitously expressed at the mRNA level. The LIM motif has been previously identified in many developmentally important factors from various eukaryotes. These factors have been shown to play a role in intracellular signaling, transcriptional regulation and cellular differentiation during development. The LIMD1 gene may have a role in tumor suppression. (from PubMed)
C24554	LIMK1_Gene	Serine-Threonine_Protein_Kinase_Gene	LIMK1 Gene|LIM Domain Kinase 1 Gene|LIMK|LIMK1	LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Two splice variant have been identified. (LocusLink)
C24555	LIMS1_Gene	Ligand_Binding_Protein_Gene	LIMS1 Gene|LIM and Senescent Cell Antigen-Like Domains 1 Gene|LIMS1|PINCH|PINCH1	The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. (LocusLink)
C24556	CEB1_Gene	Ligand_Binding_Protein_Gene	HERC5 Gene|CEB1|HERC5|Hect Domain and RLD 5 Gene|LOC51191	The CEB1 gene encodes Cyclin-E Binding Protein 1, which cyclin E, as well as other cyclins tested, specifically interacts with even in the absence of p21. CDK inhibitors, however, including p21 and p27, show either weak or no interaction with CEB1. The expression of CEB1 appears to be regulated by RB and p53. CEB1 may regulate or mediate the activity of CDKs because CEB1 is highly induced when both RB and p53 are inactivated, with subsequent elevation of CDK activity. (from OMIM)
C24557	Link-GEFII_plus_H1171Gene	Signaling_Pathway_Gene	RAPGEFL1 Gene|LOC51195|LOC51195 Gene|Link-GEFII|RAPGEFL1|Rap Guanine Nucleotide Exchange Factor (GEF)-Like 1 Gene	The Link-GEFII gene encodes Link Guanine Nucleotide Exchange Factor II, which is a Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. This protein is a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. (from LocusLink and PubMed)
C24558	LOH11CR2A_Gene	Gene_with_Unknown_or_Unclassified_Function	LOH11CR2A Gene|BCSC-1|LOH11CR2A|Loss of Heterozygosity, 11, Chromosomal Region 2, Gene A	The LOH11CR2A gene encodes BCSC-1, a predicted 438-amino acid protein. The LOH11CR2A coding region is composed of 10 exons and spans 30 to 40 kb. There are at least 2 additional exons encoding the 5-prime untranslated region. LOH11CR2A is expressed ubiquitously as a 3.3-kb mRNA. BCSC-1 is a putative tumor suppressor, but unlikely to be involved in the tumorigenic process. (from LocusLink and OMIM)
C24559	LOX_Gene	Oxidoreductase_Gene	LOX Gene|LOX|Lysyl Oxidase Gene	The protein encoded by this gene is an extracellular copper enzyme that initiates the crosslinking of collagens and elastin. The enzyme catalyzes oxidative deamination of the epsilon-amino group in certain lysine and hydroxylysine residues of collagens and lysine residues of elastin. In addition to crosslinking extracellular matrix proteins, the encoded protein may have a role in tumor suppression. (LocusLink)
C24560	LTB4R_Gene	G_Protein-Coupled_Receptor_Gene	LTB4R Gene|BLT1|BLTR|CMKRL1|GPR16|LTB4R|LTB4R1|LTBR1|Leukotriene B4 Receptor Gene|P2RY7|P2Y7	The LTB4R gene encodes Leukotriene B4 Receptor, which belongs to family 1 of G-protein coupled receptors. This protein is a receptor for extracellular ATP, UTP and ADP, and its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. This protein may be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. It is also a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. It is expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver, with high level of expression in lymphoid tissues. (from Swiss-Prot)
C24561	LTBP2_Gene	Ligand_Binding_Protein_Gene	LTBP2 Gene|LTBP2|LTBP3|Latent Transforming Growth Factor Beta Binding Protein 2 Gene	LTBP2 encodes a latent transforming growth factor-beta (TGF-beta) binding protein. LTBP2 binding of TGF-beta in the extracellular-matrix serves as an important mechanism to regulate TGF-beta function. Mutations in LTBP2 have been identified in two instances of atypical Marfan syndrome. (LocusLink)
C24562	LTK_Gene	Receptor_Tyrosine_Kinase_Gene	LTK Gene|LTK|Leukocyte Tyrosine Kinase Gene|TYK1	The LTK gene encodes Leukocyte Tyrosine Kinase. A set of cDNAs represents differently spliced human LTK mRNAs. These cDNAs predict a truncated receptor protein lacking the tyrosine kinase domain and a soluble receptor protein that has neither a transmembrane nor a tyrosine kinase domain. The LTK gene produces not only the putative receptor tyrosine kinase for unknown ligand but also multiple protein products that may have different functions. (from OMIM)
C24563	LY6E_Gene	Growth_Factor_Receptor_Gene	LY6E Gene|LY6E|Lymphocyte Antigen 6 Complex, Locus E Gene|RIG-E|RIGE|SCA-2|SCA2|TSA-1	LY6E gene is 4.0 kb long and consists of 4 exons and 3 introns. The deduced amino acid sequence predicts a cell surface protein containing 20 amino acids at the N-terminal end corresponding to a signal peptide and an extracellular sequence containing 111 amino acids. LY6E encoded protein shares some homology with CD59 and with a number of growth factor receptors. It shares high sequence homology with the murine LY6 multigene family, whose members are small cysteine-rich proteins differentially expressed in several hematopoietic cell lines and with apparent function in signal transduction. RIGE is the closest human homolog of the LY6 family. The expression of RIGE is not restricted to myeloid differentiation, because it is also present in thymocytes and in a number of other tissues at different levels. By Northern blot analysis, the highest expression of RIGE was found in liver, kidney, and ovary in addition to peripheral blood leukocytes. (OMIM)
C24564	LYL1_Gene	Ligand_Binding_Protein_Gene	LYL1 Gene|LYL1|Lymphoblastic Leukemia Derived Sequence 1 Gene	The human LYL1 gene encodes Lymphoblastic Leukemia Derived Sequence 1, which contains 1 basic helix-loop-helix (bHLH) domain. Efficient DNA binding of this protein requires dimerization with another bHLH protein. This gene is involved in a form of T-cell acute lymphoblastic leukemia (T-ALL) through a chromosomal translocation t(7;9)(q35;p13) which involves LYL1 and T-cell receptor beta chain (TCRB) genes. (from Swiss-Prot)
C24565	MADD_Gene	Adaptor_Signaling_Protein_Gene|Apoptosis_Promoter_Gene	MADD Gene|DENN|IG20|KIAA0358|MADD|MAP-Kinase Activating Death Domain Gene	Composed of 0.73-1.23-kb exons and 0.17-5.3-kb introns, 61-kb human MADD Gene at 11p11.2 is expressed in adult testis, ovary, brain, heart, and fetal brain and kidney. Eight transcript variants (encoding isoforms A-G) involve variable use of exons 1, 13, 16, 21, 26, and 34. Variant 4 encodes full-length 1588-amino acid 176.6-kD MADD Protein isoform D. Most isoform variations involve 2-4 stretches of 18-43-aa in the central region. Isoforms F and G have a different C-terminus. Containing a C-terminal death domain, RGD motif, and a leucine zipper-like motif, SER- and LEU-rich membrane-bound MADD adaptor protein interacts with TNFR1 death domain to propagate apoptotic signaling. MADD can activate ERK2 and JNK1 MAP kinases and induce phosphorylation of Phospholipase A2. MADD appears to link TNFR1 with MAP kinase activation and arachidonic acid release. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24566	MADH2_Gene	Signaling_Pathway_Gene|Transcription_Factor_Gene	SMAD2 Gene|JV18|JV18-1|MADH2|MADH2 Gene|MADR2|SMAD, Mothers Against DPP Homolog 2 (Drosophila) Gene|SMAD2	Ubiquitously transcribed from CpG promoters and 3-Mb proximal to SMAD4, 12-exon 90-kb human MADH2 Gene (SMAD Family) at 18q21.1 expresses 2.9- and 3.4-kb transcripts encoding 438/467-aa 52-kD SMAD2 containing a DWA/MH1 and DWB/MH2 domain. SMADs mediate Activin, TGFB, and BMP receptor Ser/Thr kinase cell growth/differentiation regulation. Retained by cytoplasmic SARA, SMAD2/SMAD3 are phosphorylated on conserved C-terminal MH2 docking SER-X-SERs by activated receptor. SMAD2/SMAD3 oligomerize with nuclear SMAD4, disrupting SNON/SMAD4 repressors. SMAD3 causes SNON degradation. SMAD2/SMAD4 activate target promoters. TGFBR activity maintains nuclear SMADs and increases feedback SNON expression. SMAD2 interacts with FAST-1/-2, TGIF, PEBP2-A, CBP, p300, c-SKI, NUP214, NUP153, and SMURF2. MADR2 mutations may disrupt growth inhibition. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24567	MADH6_Gene	Signaling_Pathway_Gene	MADH6 Gene|MADH6|SMAD, Mothers Against DPP Homolog 6 (Drosophila) Gene|SMAD6	The 79.7-kb human MADH6 Gene (SMAD Family) at 15q21-q22 is ubiquitously expressed (predominantly in vascular endothelium) as alternative SMAD6 Protein isoform A (496-aa 53.5-kD) and isoform B (235-aa), similar to other MAD-related proteins acting as second messengers distal to TGFBRs and containing an N-terminal DWA/MH1 domain and a C-terminal DWB/MH2 domain. An inhibitory SMAD phosphorylated by type 1 receptor kinase, SMAD6 acts as an antagonist of TGF-beta type 1 receptor signaling. A selective inhibitor of BMPs signaling; SMAD6 competes with SMAD4 for receptor-activated SMAD1. SMAD6 interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8, and HOXC9. MADH6 and MADH7 form complexes. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24568	MADH7_Gene	Adaptor_Signaling_Protein_Gene	SMAD7 Gene|MADH7|MADH7 Gene|MADH8|SMAD, Mothers Against DPP Homolog 7 (Drosophila) Gene|SMAD7	Induced by TGF-beta and IFNG, ubiquitously expressed (lung and vascular endothelium highest) 31-kb human MADH7 Gene (SMAD Family) at 18q21.1 encodes 426-amino acid SMAD7 Protein, an Activin/TGFBR1 signaling inhibitory component containing DWA/MH1 and DWB/MH2 domains and lacking the C-terminal phosphorylation sites of other MAD proteins, suggesting distinct regulation. Adaptor SMAD7 constitutively recruits nuclear E3 ubiquitin ligase SMURF2 to TGFBR complexes preventing SMAD2 access and causing proteasomal and lysosomal receptor degradation. SMAD7-expressing cells are susceptible to apoptosis induced by TGFB, TNFA, serum withdrawal, or loss of cell adhesion. SMAD7 decreases NFKB activity, promoting apoptosis. RAS suppresses SMAD7 inhibition of NFKB and potentiation of apoptosis. MADH7 and MADH6 form complexes. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24569	MADHIP_Gene	Adaptor_Signaling_Protein_Gene	ZFYVE9 Gene|MADHIP|SARA|ZFYVE9|Zinc Finger, FYVE Domain Containing 9 Gene	The 204-kb human MADHIP Gene at 1p32.3 expresses ubiquitous alternate transcripts: full-length isoform 1 (1425-aa, 156 kD), variant 2 (1210-aa), variant 3 (762-aa). 3-Prime abbreviated, variant 2 encodes a truncated protein. Translation initiates downstream in variant 3; the 5-prime UTR and 3-prime region differ. Cytoplasmic SARA Protein contains a FYVE domain zinc finger, seen in signaling molecules and required for SARA localization but not SMAD interaction. Able to bind PI-3 phosphate, SARA recruits SMAD2/3 to TGFBR. The SMAD binding domain (SBD) of SARA interacts with the SMAD2/3 MH2 domain; the C-terminal domain interacts with TGFBR. SMAD2/SMAD3 phosphorylation induces SARA dissociation, SMAD2/SMAD4 formation, and SMAD nuclear translocation. Disruption of MADHIP appears to be involved in Alzheimer's disease. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24570	MAGED1_Gene	Adaptor_Signaling_Protein_Gene|Apoptosis_Promoter_Gene	MAGED1 Gene|DLXIN1|MAGED1|Melanoma Antigen Family D, 1 Gene|NRAGE	The 99.5-kb human MAGED1 Gene (MAGE Family) at Xp11.23 seems to express a ubiquitous 778-amino acid 86-kD cytoplasmic NRAGE Protein that contains a 200-amino acid MAGE homology domain. NRAGE appears to shift from cytoplasm to plasma membrane upon NGF stimulation to interact with p75NTR. NRAGE antagonizes p75NTR association with TRKA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. NRAGE may regulate the function of DLX family members. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24571	MAP2K6_Gene	Apoptosis_Promoter_Gene|Signaling_Pathway_Gene	MAP2K6 Gene|MAP2K6|MAPKK6|MEK6|MKK6|Mitogen-Activated Protein Kinase Kinase 6 Gene|PRKMK6|SAPKK3	Activated by UV and osmotic shock, the 128.6-kb human MAP2K6 Gene (MAP2K Family) at 17q24.3 expresses a 1.7-kb transcript in skeletal muscle that encodes 278-aa MKK6. Longer at the N-terminus, MKK6B (334-aa, 37.5-kD) is encoded by 1.8-, 2.4-, and 4.5-kb transcripts enriched in heart, skeletal muscle, pancreas, and liver. Tissue-specific splicing may control of MKK6 expression. MKK6 is about 80% identical to MKK3 and 40% identical to MKK4. Probably activated by Ser/Thr phosphorylation, MKK6 Thr/Tyr phosphorylates p38-MAPK exclusively in response to inflammatory cytokines or environmental stress, inducing cell cycle arrest, transcription activation, and apoptosis. Calcium influx triggers the MKK6/p38-MAPK cascade; p38-MAPK activates MEF2s that regulate expression of genes critical for cell survival. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24572	MAP3K1_Gene	Signaling_Pathway_Gene|Ubiquitin_Ligase_Gene	MAP3K1 Gene|MAP3K1|MAPKKK1|MEKK|MEKK1|Mitogen-Activated Protein Kinase Kinase Kinase 1 Gene	The 78-kb human MAP3K1 Gene (MAP3K Family) at 5q11.2 encodes a Ser/Thr MEKK1 Protein pivotal in the phosphorylation network that integrates cellular responses to mitogenic and metabolic stimuli. IFNG induces MEKK1 expression. An efficient activator of the JNK cascade, MEKK1 can phosphorylate MEK1/MEK2, which activate MAPKs. The PHD domain of MEKK1, a RING-type zinc finger, exhibits E3 ubiquitin ligase activity toward ERK2. Thus, MEKK1 functions as both an upstream activator of ERK and JNK through its kinase domain and as an E3 ligase through its PHD domain, decreasing ERK1/ERK2 activity. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24573	MAP3K14_Gene	Signaling_Pathway_Gene	MAP3K14 Gene|FTDCR1B|HS|HSNIK|MAP3K14|Mitogen-Activated Protein Kinase Kinase Kinase 14 Gene|NIK	Expressed as a single 5-kb transcript from 15 exons in small intestine, spleen, thymus, peripheral leukocytes, testis, prostate, ovary, and colon, the 27.8-kb human MAP3K14 Gene (MAP3K Family) at 17q21 encodes autophosphorylated 947-amino acid 104-kD cytoplasmic Ser/Thr Protein Kinase NIK, involved in NFKB activation. NIK selectively activates NFKB cascades of TNF/NGF receptors and IL1R type-I. TNFA acts through TRAF2; IL1 acts through IRAK1 and TRAF6. LTBR and CD95 also act through NIK. NIK appears to bind TRAFs 2, 5, and 6, IKKA, and NFKB2/p100. Binding to TRAF2 involves the TRAF2 N- and C-terminal regions. NIK induces NFKB2/p100 processing, degradation of phosphoserine-induced ubiquitinated destruction of IKBA, and release of cytoplasmic NFKB for nuclear translocation and kappa-B DNA-mediated gene expression.  (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24574	MAP3K7_Gene	Serine-Threonine_Protein_Kinase_Gene	MAP3K7 Gene|MAP3K7|Mitogen-Activated Protein Kinase Kinase Kinase 7 Gene|TAK1|TGF1A	With a TATA-less and CpG island promoter, 71.6-kb 17-exon human MAP3K7 Gene (MAP3K Family) at 6q16.1-q16.3 generates ubiquitous 3.2 to 5.7-kb variants involving exons 12 and 16 that encode TAK1 Protein isoforms A, B (606-aa, 67.2-kD), C, and D. A, C, and D lack 1-2 coding segments compared to B. C and D frameshifts yield shorter C-termini (may affect TAB2 interaction). Human and mouse TAK1 are 99% identical. The TAK1 N-terminus interacts with TAB1 and contains ATP-binding and kinase domains. Regulating transcription and apoptosis, TAK1 mediates TGFB/BMP, IL-1, and stress signaling. With TAB1 and TAB2, TRIKA2-mediated (TRAF6/TRIKA1) ubiquitinated TAK1 phosphorylates IKKB, MAP2K3, MAP2K4, and MAP2K6, which stimulate JNK1 and SAPK2. TAK1 induces NIK-independent IKBA and IKBB degradation and NFKB p50/p65 nuclear translocation. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24575	MAP3K7IP1_Gene	Signaling_Pathway_Gene	MAP3K7IP1 Gene|MAP3K7IP1|Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1 Gene|TAB1	The 37-kb human MAP3K7IP1 Gene at 22q13.1 generates a ubiquitous 3.5-kb mRNA that encodes 504-amino acid 54.6-kD TAK1-Binding Protein 1, a MAP3K responsible for mediation of TGF-beta receptors and activation of TAK1 kinase. The 68 C-terminal amino acids are sufficient for binding and activation of TAK1 kinase activity. The N-terminal 418 amino acids inhibit TGFB-induced gene expression. TAB1 contains a PP2C domain and amino acids 373-418 are required for phosphorylation of p38-alpha. Formation of TRAF6/TAB1/p38-alpha complexes are enhanced by lipopolysaccharide. TAB1 also interacts with BIRC7. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24576	MAP4K4_Gene	Signaling_Pathway_Gene	MAP4K4 Gene|FLH21957|HGK|KIAA0687|MAP4K4|Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Gene|NIK	The ubiquitously expressed 195-kb human MAP4K4 Gene (SER/THR Family, STE20 Subfamily) at 2q11.2-q12 generates 5 tissue alternative isoforms of HGK Protein; variant 2 is longest and contains proline-rich domains. Compared to variant 2, variants 1 and 3 lack two coding segments; variant 1 contains an extra coding segment. HGK contains a CNH domain and an N-terminal catalytic domain with 11 kinase subdomains; it shares 47-48% amino acid identity with HPK1 and GCK catalytic domains. In response to environmental stress and cytokines such as TNFA, HGK appears to act through MAP3K7, MAP2K4, and MAP2K7 cascades to activate JNK and the c-JUN N-terminal transcriptional pathway. HGK may interact with the SH3 domain of NCK adapter proteins. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24577	MAPK10_Gene	MAP_Kinase_Gene	MAPK10 Gene|FLJ12099|JNK3|JNK3A|MAPK10|Mitogen-Activated Protein Kinase 10 Gene|PRKM10|p493F12|p54bSAPK	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kinase 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants. (LocusLink)
C24578	MAPK11_Gene	MAP_Kinase_Gene	MAPK11 Gene|MAPK11|Mitogen-Activated Protein Kinase 11 Gene|P38B|P38BETA2|PRKM11|SAPK2|SAPK2B|p38-2|p38Beta	MAPK11 Gene encodes MAP Kinase 11, a member of the MAP kinase family of integration points for multiple biochemical signals and involved in a variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK11 is most closely related to p38 MAP kinase; both can be activated by proinflammatory cytokines and environment stress. MAPK11 is activated through phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of MAPK11. (NCI)
C24579	MAPK12_Gene	MAP_Kinase_Gene	MAPK12 Gene|ERK3|ERK6|MAPK12|Mitogen-Activated Protein Kinase 12 Gene|P38Gamma|PRKM12|SAPK-3|SAPK3	Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. SAPK3 functions as a signal transducer during differentiation of myoblasts to myotubes. (LocusLink)
C24580	MAPK13_Gene	MAP_Kinase_Gene	MAPK13 Gene|MAPK13|Mitogen-Activated Protein Kinase 13 Gene|PRKM13|SAPK4|p38delta	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and cellular stress. MAP kinase kinases 3, and 6 can phosphorylate and activate this kinase. Transcription factor ATF2, and microtubule dynamics regulator stathmin have been shown to be the substrates of this kinase. (LocusLink)
C24581	MAPK14_Gene	MAP_Kinase_Gene	MAPK14 Gene|CSBP1|CSBP2|CSPB1|EXIP|MAPK14|Mitogen-Activated Protein Kinase 14 Gene|Mxi2|PRKM14|PRKM15|RK|SAPK2A|p38|p38 MAPK Gene|p38Alpha	Expressed in brain, heart, placenta, pancreas, skeletal muscle, lung, liver, and kidney, 83-kb alternatively spliced human MAPK14 Gene (MAPK Family) at 6p21.3-p21.2 encodes four isoforms (varying by internal segments and C-termini) of (Ser/Thr) Mitogen-Activated Protein Kinase 14, involved in oxidative/hypoxic/environmental/genotoxic stress, transcription, cell cycle regulation, and apoptosis. Bound to cytoplasmic PTPRR and activated by cell stress, proinflammatory cytokines, LPS, Thr/Tyr phosphorylation by MAP2K3, MAP2K6, and MAP2K4, and autophosphorylation by MAP3K7IP1/TAB1 interaction, p38 MAPK phosphorylates MAPKAPK2, MAPKAPK5, ELK-1, ATF2, MEF2C, MAX, CDC25B, and p53. p38 is inhibited by DUSP1 and CSAID drugs. (NCI)
C24582	MAPK4_Gene	MAP_Kinase_Gene	MAPK4 Gene|ERK3|ERK3-Related|MAPK4|Mitogen-Activated Protein Kinase 4 Gene|PRKM4|p63MAPK	Highly expressed in heart and brain, human MAPK4 Gene (MAPK Family) encodes 557-aa 63-kDa MAP Kinase 4, a Ser/Thr protein kinase activated by tyrosine kinase growth factor receptors that translocates to the nucleus to phosphorylate nuclear targets and likely promote entry in the cell cycle. MAPK4 also phosphorylates MAP2. (NCI)
C24583	MAPK6_Gene	MAP_Kinase_Gene	MAPK6 Gene|ERK3|MAPK6|Mitogen-Activated Protein Kinase 6 Gene|PRKM6|p97MAPK	Expressed in skeletal muscle, brain, heart, placenta, lung, liver, pancreas, kidney, and fibroblasts, human MAPK6 Gene (MAPK Family) encodes 721-aa 83-kDa nuclear MAP Kinase 6, a Ser/Thr protein kinase activated by protein phosphorylation cascades that acts as an integration point for multiple biochemical signals and likely promotes entry in the cell cycle. MAPK6 phosphorylates MAP2. (NCI)
C24584	MAPK7_Gene	MAP_Kinase_Gene	MAPK7 Gene|BMK1|ERK4|ERK5|MAPK7|Mitogen-Activated Protein Kinase 7 Gene|PRKM7	Highly expressed as four alternative transcripts in heart, placenta, lung, kidney, and skeletal muscle, human MAPK7 Gene (MAPK Family) encodes 815-aa 88.6-kDa MAP Kinase 7, a Ser/Thr kinase specifically activated by MAP2K5 (not MEK1/MEK2) and involved as an integration point for multiple downstream signals of various receptors, including receptor type kinases and GPCRs, in cell proliferation, differentiation, transcription regulation, and development. Autophosphorylated and likely activated by tyrosine and threonine phosphorylation by upstream kinase, MAPK7 translocates to the nucleus in response to extracellular signals and regulates gene expression by phosphorylating and activating target transcription factors. The C-terminus may have an autoregulatory role, and the second Pro-rich region may interact with actin, targeting MAPK7 to specific cell locations. (NCI)
C24585	MAPK9_Gene	MAP_Kinase_Gene	MAPK9 Gene|JNK-55|JNK2|JNK2A|JNK2Alpha|JNK2B|JNK2Beta|MAPK9|Mitogen-Activated Protein Kinase 9 Gene|PRKM9|p54aSAPK	Expressed as alpha-1, -2, beta-1, -2 isoforms, human MAPK9 Gene (MAPK Family) encodes MAP Kinase 9, a stress/cytokine-induced Ser/Thr kinase that acts as an integration point for multiple biochemical signals involved in target transcription factor regulation, such as c-Jun and ATF2. Alpha-1, and 2 bind c-Jun; beta-1 and 2 bind ATF2. JunB and JunD are not substrates for alpha-2. Inhibited by dual specificity phosphatases, and phosphothreonine/tyrosine activated by a Ras-dependent dual specificity MAP2K4/MAP2K7 cascade, MAPK9 mediates immediate-early gene expression. MAPK9 binds scaffolding proteins MAPK8IP1/2/3. MAPK9/UV-induced apoptosis appears related to cytochrome c-mediated cell death. Increased p53 stability in nonstressed cells results from MAPK9 blocked p53 ubiquitination. MAPK9 appears required for T-helper cell differentiation into Th1 cells. (NCI)
C24586	MAPRE1_Gene	Ligand_Binding_Protein_Gene	MAPRE1 Gene|EB1|MAE1|MAPRE1|Microtubule-Associated Protein, RP/EB Family, Member 1 Gene	Human MAPRE1 Gene (MAPRE/RP/EB Family) encodes 268-aa 30-kDa Microtubule-Associated Protein RP/EB Family Member 1, containing a CH domain and a C-terminal domain that binds to APC. In interphase, MAPRE1 localizes to microtubules (growing ends); during mitosis, MAPRE1 is associated with centrosomes and spindle microtubules. MAPRE1 also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. MAPRE1 also interacts with TERF1. MAPRE1 is likely involved in regulation of microtubule structures, microtubule polymerization, spindle function, and chromosome stability. (NCI)
C24587	MATK_Gene	Non-Receptor_Tyrosine_Kinase_Gene	MATK Gene|CHK|CTK|DKFZp434N1212|HHYLTK|HYL|Lsk|MATK|MGC1708|MGC2101|Megakaryocyte-Associated Tyrosine Kinase Gene	This gene encodes a protein that has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. There are three alternatively spliced transcript variants described for this gene encoding different isoforms. (LocusLink)
C24588	MCT-1_Gene	Gene_with_Unknown_or_Unclassified_Function	MCTS1 Gene|MCT-1|MCTS1|Malignant T Cell Amplified Sequence 1 Gene	Human MCT-1 Gene encodes MCT-1 Protein, of unknown function. (NCI)
C24589	MDK_Gene	Growth_Factor_Gene	MDK Gene|MDK|MK1|Midkine (Neurite Growth-Promoting Factor 2) Gene|NEGF2	This gene encodes neurite outgrowth-promoting factor 2, a 143-residue protein which is a precursor for a mature protein of 121 amino acids and is 46% homologous with another heparin-binding neurite outgrowth-promoting factor, NEGF1. NEGF2 is also known as midkine. Midkine was first found in differentiating mouse teratocarcinoma cells. It has neurotrophic activities and is mitogenic to certain, but not to all, fibroblast cell lines.(from OMIM)
C24590	MEIS1_Gene	Ligand_Binding_Protein_Gene	MEIS1 Gene|MEIS1|MEIS1, Myeloid Ecotropic Viral Integration Site 1 Homolog (Mouse) Gene	Expressed in immunohepatopoietic tissues and in brain, human MEIS1 Gene (TALE/MEIS Family) encodes 390-aa 43-kDa Homeobox Protein MEIS1, containing one homeobox domain, the only conserved motif in the entire protein. Homeobox genes play a crucial role in normal development. Mouse Meis1 regulates Pbx1 protein activity by promoting nuclear import and specifies cell fates and differentiation patterns along the proximodistal limb axis. (NCI)
C24591	MERTK_Gene	Receptor_Tyrosine_Kinase_Gene	MERTK Gene|C-MER Proto-Oncogene Tyrosine Kinase Gene|MER|MERK|MERTK|c-mer	Expressed in monocytes, bone marrow, and tissues of epithelial and reproductive origin, human MERTK Gene (AXL/UFO Family) encodes 999-aa 110-kDa (precursor) Receptor Tyrosine Kinase MERTK, containing 2 extracellular N-terminal Ig-like C2-type domains and 2 membrane proximal fibronectin type III domains, a putative transmembrane segment, a tyrosine kinase KWIAIES domain, several N-glycosylation sites, and tyrosine phosphorylation sites. Not expressed in normal B- and T-lymphocytes, MERTK is expressed in numerous neoplastic B-and T-cell lines. MERTK defects cause retinitis pigmentosa. (NCI)
C24592	MFGE8_Gene	Membrane_Protein_Gene	MFGE8 Gene|BA46|EDIL1|MFGE8|Milk Fat Globule-EGF Factor 8 Protein Gene	Expressed by mammary epithelia and activated macrophages, human MFGE8 Gene encodes 387-aa 43-kDa (precursor) Milk Fat Globule-EGF Factor 8 Protein, a multidomain cell surface (and secreted) protein that contains an EGF-like domain, C-terminal F5/8 type C domains, and the cell adhesion tripeptide RGD. MFGE8 recognizes aminophospholipids (phosphatidylserine) and binds to cells via its RGD motif; MFGE8 binds strongly to cells expressing alpha-V-beta-3 integrin. Expressed by activated macrophages, MFGE8 specifically binds to apoptotic cells and appears to promote macrophage phagocytosis of apoptotic cells. MFGE8 is overexpressed in several carcinomas. (NCI)
C24593	MFHAS1_Gene	Gene_with_Unknown_or_Unclassified_Function	MFHAS1 Gene|MASL1|MFHAS1|Malignant Fibrous Histiocytoma Amplified Sequence 1 Gene	Ubiquitously expressed as a 6.6-kb transcript, human MFHAS1 Gene encodes 1,052-aa 117-kDa MASL1 Protein, containing an ATP/GTP-binding site, 3 leucine zipper regions, and a leucine-rich tandem repeat (often elements of interaction among proteins related to the cell cycle). MASL1 shares 36% sequence homology with IGFALS. (NCI)
C24594	MFNG_Gene	Signaling_Pathway_Gene	MFNG Gene|MFNG|Manic Fringe Homolog (Drosophila) Gene	This gene is a member of the fringe gene family which also includes Radical and Lunatic fringe. They all encode evolutionarily conserved secreted proteins that participate in the Notch signaling pathway in determining boundaries during segmentation and cell fates during neurogenesis. (from LocusLink and OMIM)
C24595	MGP_Gene	Gene_with_Unknown_or_Unclassified_Function	MGP Gene|MGLAP|MGP|Matrix Gla Protein Gene	Upregulated by vitamin D in bone cells and expressed at high levels in heart, kidney, and lung, 3.9-kb 4-exon human MGP Gene (Osteocalcin/MGP Family) encodes 103-aa 12-kDa (precursor) secreted Matrix Gla Protein, associated with the organic matrix of bone and cartilage and a putative inhibitor of bone formation. Like all known vertebrate vitamin K-dependent proteins, MGP contains a transmembrane signal peptide, a putative gamma-carboxylase recognition site, and a Gla-containing domain. MGP requires vitamin K-dependent gamma-carboxylation for its function. (NCI)
C24596	MIF_Gene	Cytokine_Gene	MIF Gene|GIF|GLIF|Glycosylation-Inhibiting Factor Gene|MIF|MMIF|Macrophage Migration Inhibitory Factor (Glycosylation-Inhibiting Factor) Gene|Macrophage Migration Inhibitory Factor Gene	This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. (Locuslink)
C24597	CXCL9_Gene	CXC_Cytokine_Gene	CXCL9 Gene|CMK|CXCL9|Chemokine (C-X-C Motif) Ligand 9 Gene|Humig|MIG|MIG Gene|SCYB9|crg-10	Induced by INF gamma and oriented head-to-tail and separated by less than 16-kb with INP10, human CXCL9 Gene (Intercrine Alpha/Chemokine CXC Family) at 4q21 encodes secreted 125-aa 14-kD (precursor) chemoattractant (T-cells) Small Inducible Cytokine B9 that binds to CXCR3 and is involved in angiogenesis and T-cell activation in inflammatory responses. (NCI)
C24598	MKNK1_Gene	Signaling_Pathway_Gene	MKNK1 Gene|MAP Kinase Interacting Serine/Threonine Kinase 1 Gene|MKNK1	Widely expressed (3-kb mRNA), human MKNK1 Gene (Ser/Thr Kinase Family) encodes alternative 465-aa (51-kDa) and 424-aa MAP Kinase Interacting Kinase 1 isoforms, containing a typical Ser/Thr kinase domain, an N-terminal putative NLS, and sharing homology with MAPKAPK2, MAPKAPK3, and p90(RSK). Strongly interacting with, and phosphorylated/activated (via C-terminal region) by, dephosphorylated p38MAP and ERK kinases, but not JNK/SAPK, MKNK1 is activated by many extracellular mitogenic and stress stimuli. Docking with EIF4G1 and -2 C-terminal regions, MNK1 appears to regulate transcription by phosphorylating EIF4E and increasing affinity for the 7-methylG mRNA cap. MNK1 also interacts with the translational inhibitor p97 C-terminus. p97 may sequester MNK1, blocking eIF4E phosphorylation. (NCI)
C24599	MKPX_Gene	Protein_Phosphatase_Gene	DUSP22 Gene|DUSP22|Dual Specificity Phosphatase 22 Gene|JKAP|JSP1|MKPX	Human MKPX Gene encodes 184-aa 21-kDa Dual Specificity Phosphatase 22. While MAP kinases play a pivotal role in cellular signal transduction, dual-specificity phosphatases can reverse MAP kinase activation by dephosphorylating critical phosphotyrosine and phosphothreonine residues. (NCI)
C24600	MLL2_Gene	Gene_with_Unknown_or_Unclassified_Function	MLL2 Gene|ALR|MLL2|Myeloid/Lymphoid or Mixed-Lineage Leukemia 2 Gene	Expressed (18-kb mRNA) in most adult tissues, including hematopoietic cells, except liver, human MLL2 Gene (TRX Family) encodes alternative 5262-aa (564-Da) and 4957-aa isoforms of Myeloid/Lymphoid or Mixed-Lineage Leukemia Protein 2, a putative nuclear transcription factor of the ASCOM complex likely to play a similar role to ALL1 and TRX, although the target genes have yet to be identified. The 5262-aa isoform contains 5 PHD-type zinc fingers, 1 post-SET domain, 1 RING-type zinc finger, and 1 SET domain; the 4957-aa isoform lacks an N-terminal zinc finger and a PHD finger. MLL2 contains 24 amino acid runs, all but 2 of which are Glu runs; proteins with similar features play roles in transcription, translation, and developmental regulation. (NCI)
C24601	MLLT1_Gene	Transcription_Factor_Gene	MLLT1 Gene|ENL|LTG19|MLLT1|Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated to, 1 Gene	Human MLLT1 Gene encodes 559-aa 62-kDa nuclear ENL Protein, a protein similar to MLLT3/AF9 (Human), TFG3/ANC1 (Yeast), and trithorax (Drosophila) that contains nuclear targeting sequences, serine- and proline-rich regions, and stretches abundant in basic amino acids and appears capable of transcriptional transactivation in lymphoid and myeloid cells. The C-terminal 90-aa of MLLT1 are required for activation of transcription. A common acute leukemia chromosomal translocation t(11;19)(q23;p13.3) involves MLL/HRX and MLLT1 that results in a rogue chimeric activator protein containing the MLL N-terminal AT-hook motifs. (NCI)
C24602	MLLT2_Gene	Transcription_Factor_Gene	MLLT2 Gene|AF-4|AF4|MLLT2|Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated to, 2 Gene	Widely expressed as a single transcript of nearly 10-kb, human MLLT2 Gene (AF4 Family) encodes 1210-aa 131-kDa AF-4 Protein, a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus and high sequence homology with ENL protein. A common acute leukemia chromosomal translocation t(4;11)(q21;q23) involves a fusion of MLLT2 and MLL/HRX that form reciprocal products coding for chimeric rogue proteins. (NCI)
C24603	MLLT3_Gene	Transcription_Factor_Gene	MLLT3 Gene|AF9|MLLT3|Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated to, 3 Gene	Human MLLT3 Gene, more than 100-kb, encodes 568-aa 63-kDa AF-9 Protein, putative transcription factor similar to TFG3/ANC1 (Yeast) and containing similar functional domains as MLLT1 and MLLT2 (Human), including nuclear targeting sequences, serine-rich and proline-rich regions, and stretches abundant in basic amino acids. BCR1 is located within intron 4; BCR2 spans introns 7 and 8. A common acute leukemia chromosomal translocation t(9;11)(p22;q23) involves a fusion of MLLT3 and MLL/HRX that produces a chimeric rogue activator protein. (NCI)
C24604	MLLT4_Gene	Gene_with_Unknown_or_Unclassified_Function	MLLT4 Gene|AF-6|AF6|AFADIN|MLLT4|Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated to, 4 Gene	Expressed in a variety of cell types, human MLLT4 Gene encodes 1816-aa 206-kDa AF-6 Protein, a possible signal transduction protein controlled by Ras signaling pathways that is strongly similar to afadin (rat) and contains short stretches rich in proline, charged amino acids, serines, or glutamines, 1 dilute domain, 1 FHA domain, 1 PDZ/DHR domain, and 2 RAS-associating domains. Shared with several vertebrate and invertebrate proteins, the MLLT4 GLGF motif may be involved in signal transduction at special cell-cell junctions. MLLT4 binds directly to ZO-1 and occludin. MLLT4 may bind to actin filaments, linking the actin cytoskeleton to the plasma membrane at cell-to-cell adherens junctions. A common acute leukemia chromosomal translocation t(6;11)(q27;q23) involves fusion of MLLT4 and MLL/HRX that results in production of a rogue activator protein. (NCI)
C24605	MLLT6_Gene	Transcription_Factor_Gene	MLLT6 Gene|AF17|MLLT6|Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated to, 6 Gene	Human MLLT6 Gene encodes 1093-aa 112-kDa AF-17 Protein, high similarity to AF10 and containing amino acid stretches associated with transcriptional repression or activation: a 3-prime leucine-zipper dimerization motif and a terminal cysteine-rich domain of 3 zinc fingers (2 PHD-type) similar to a domain in Br140 protein. A common acute leukemia chromosomal translocation t(11;17)(q23;q21) involves fusion of MLL/HRX and MLLT6 that produces a rogue activator protein. (NCI)
C24606	MLLT7_Gene	Transcription_Factor_Gene	MLLT7 Gene|AFX|AFX1|FOXO4|MLLT7|Myeloid/Lymphoid or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated to, 7 Gene	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas, 3-exon human MLLT7 Gene (Forkhead Family) encodes 505-aa 54-kDa Forkhead Box Protein O4, highly similar to forkhead transcription factor FKHR protein within its single forkhead domain and containing serine- and proline-rich regions like ENL protein. AFX-like proteins appear involved in cell cycle regulation. MLLT7 appears to block cell cycle progression at G1, independent of Rb but dependent on p27(KIP1). MLLT7 transcriptionally activates p27(KIP1). MLLT7 may also play a role in the insulin signaling pathway. Acute leukemia chromosomal translocation t(X;11)(q13;q23) involves MLLT7 fused to MLL/HRX that encodes a chimeric rogue activator protein. (NCI)
C24607	MME_Gene	Metalloproteinase_Gene	MME Gene|CALLA|CD10|MME|Membrane Metallo-Endopeptidase (Neutral Endopeptidase, Enkephalinase, CALLA, CD10) Gene|NEP	Expressed in a variety of tissues, but abundant in the kidney proximal tubule brush border and glomerular epithelium, 24-exon 80-kb single copy human MME Gene (M13 Peptidase Family) encodes (initiation in exon 3) 749-aa 100-kDa Membrane Metalloendopeptidase, a zinc-binding type II transmembrane glycoprotein that preferentially cleaves Gly-Phe bonds of peptides at the N side of hydrophobic residues and inactivates several peptide hormones, including insulin, glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin, as well as casein, hemoglobin, and other proteins and polypeptides. An important cell surface marker of human acute lymphocytic leukemia, MME is present on pre-B leukemic cells, which represent 85% of cases of ALL. (NCI)
C24608	MMP11_Gene	Metalloproteinase_Gene	MMP11 Gene|MMP11|Matrix Metalloproteinase 11 (Stromelysin 3) Gene|SL-3|ST3|STMY3	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. (LocusLink)
C24609	MPP1_Gene	Membrane-Associated_Guanylate_Kinase_Family_Gene	MPP1 Gene|DXS552|DXS552E|EMP55|MPP1|Membrane Protein, Palmitoylated 1, 55kDa Gene|PEMP	Expressed (2-kb mRNA) in a variety of tissues (abundantly in erythroid stem cells to differentiated reticulocytes), single copy 12-exon 28-kb human MPP1 Gene (MAGUK Family) located in a CpG island encodes 466-aa 52-kDa Palmitoylated Membrane Protein 1, containing 1 PDZ/DHR domain, 1 conserved SH3 domain, 1 guanylate kinase-like domain, and a region that binds to cytoskeletal protein 4.1. Tightly associated with the plasma membrane and extensively palmitoylated, MPP1 interacts with DLG5 and is suspected to play a role in signal transduction. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. (NCI)
C24610	MPP2_Gene	Membrane-Associated_Guanylate_Kinase_Family_Gene	MPP2 Gene|DKFZp761D0712|DLG2|MPP2|Membrane Protein, Palmitoylated 2 (MAGUK p55 Subfamily Member 2) Gene	Human MPP2 Gene (MAGUK Family) encodes 576-aa 65-kDa Palmitoylated Membrane Protein 2, suspected to play a role in signal transduction and containing 1 PDZ/DHR domain, a conserved SH3 domain, and 1 guanylate kinase-like domain. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. (NCI)
C24611	MPP3_Gene	Membrane-Associated_Guanylate_Kinase_Family_Gene	MPP3 Gene|DLG3|MAGUK p55 Subfamily Member 3 Gene|MPP3|Membrane Protein, Palmitoylated 3 (MAGUK p55 Subfamily Member 3) Gene	Human MPP3 Gene (MAGUK Family) encodes 585-aa 66-kDa Palmitoylated Membrane Protein 3, suspected to play a role in signal transduction and containing 1 PDZ/DHR domain, a conserved SH3 domain, and 1 guanylate kinase-like domain. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. (NCI)
C24612	MPZL1_Gene	Gene_with_Unknown_or_Unclassified_Function	MPZL1 Gene|MPZL1|Myelin Protein Zero-Like 1 Gene|PZR	Expressed (4-, 3.8-, and 1.3-kb mRNAs) in all tissues tested (highest in heart, placenta, kidney, and pancreas), human MPZL1 Gene (Ig Superfamily) encodes 269-aa 43-kD hyperphosphorylated cell surface membrane glycoprotein Myelin Protein Zero-Like 1 Protein, containing an N-terminal signal sequence, an extracellular Ig-like domain with potential N-linked glycosylation sites, a single membrane-spanning segment, and an intracellular pair of consensus immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Specifically binding through its ITIMs to tyrosine phosphatase PTPN11, a positive transducer of growth factor signal transduction, MPZL1 is dephosphorylated by PTPN11, but not by PTPN6, which has a negative role in hematopoietic cell proliferation. Having 45.8% identity with Myelin Protein Zero, MPZL1 may have a role in cell signaling via c-Src. (NCI)
C24613	MRAS_Gene	RAS_Family_Gene	MRAS Gene|M-RAS|MRAS|R-RAS3|RRAS3	Induced by IL9, but not IL2 or IL4, in brain and heart only, human MRAS Gene (Ras GTPase Family) encodes 208-aa 24-kDa RAS-Related Protein MRAS, a GTP-binding protein implicated in neuronal differentiation and activated by NGF, basic FGF, and guanine nucleotide exchange factor GRP, but not by EGF. Activating the MAP kinase pathway, MRAS may serve as a signal transducer to couple specific trophic factors to the MAPK cascade for cell proliferation through activation of B-Raf. (NCI)
C24614	MRVI1_Gene	Gene_with_Unknown_or_Unclassified_Function	MRVI1 Gene|IRAG|MRVI1|Murine Retrovirus Integration Site 1 Homolog|Murine Retrovirus Integration Site 1 Homolog Gene	This gene is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The protein encoded by this gene, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. Encodes an inositol 1,4,5-triphosphate-associated cGMP kinase substrate. Calcium release from the endoplasmic reticulum controls a number of cellular processes, including proliferation and contraction of smooth muscle and other cells and contributes to the antiproliferative and proapoptotic effects of nitric oxide and cGMP. (from LocusLink and OMIM)
C24615	MSC_Gene	Gene_with_Unknown_or_Unclassified_Function	MSC Gene|ABF-1|ABF1|MSC|MYOR|Musculin (Activated B-Cell Factor-1) Gene	The gene encodes musculin that contains a transcriptional repression domain and is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. MSC is a downstream target of the B-cell receptor signal transduction pathway. Mice engineered to lack the protein lack muscle structures derived from the first brachial arch. (from LocusLink and OMIM)
C24616	MST1R_Gene	Receptor_Tyrosine_Kinase_Gene	MST1R Gene|CDw136|MST1R|Macrophage Stimulating 1 Receptor (C-MET-Related Tyrosine Kinase) Gene|RON	This gene encodes a receptor of the MET receptor family. The protein is membrane-spanning disulfide-linked heterodimer with intracellular tyrosine kinase activity.  It is synthesized as a single polypeptide which is processed to the 185-kD heterodimer of 35-kD (alpha) and 150-kD (beta) subunits joined by the predicted disulfide linkage. The protein is a specific cell surface receptor for macrophage stimulating protein. Targeted expression in mice results in frequent, multiple lung tumors. It may also play a role in progression of some colorectal cancers (from OMIM, Oncogene 2002;21:6382-6 and Oncogene 2003;22:186-97)
C24617	MTCP1_Gene	Gene_with_Unknown_or_Unclassified_Function	MTCP1 Gene|C6.1B|MTCP1|Mature T-Cell Proliferation 1 Gene	Expressed in many tissues as isoforms short Type A (high in skeletal muscle) or long Type B1 (low level), human MTCP1 Gene (TCL1 Family) encodes 68-aa 8-kDa (A) or 107-aa 13-kDa (B1) mitochondrial Mature T-Cell Proliferation 1 Protein that likely has a role in mature T cell proliferation. MTCP1 is overexpressed in T-cell leukemia bearing a t(X;14) translocation. (NCI)
C24618	MUSK_Gene	Receptor_Tyrosine_Kinase_Gene	MUSK Gene|MUSK|Muscle, Skeletal, Receptor Tyrosine Kinase Gene	Called MuSK for muscle-specific kinase. It is a receptor-like tyrosine kinase restricted to skeletal muscle in its expression. Mice lacking MuSK show a defect in initiation of postsynaptic differentiation. (from OMIM)
C24619	MXI1_Gene	Transcription_Corepressor_Gene	MXI1 Gene|MAD2|MAX Interactor 1 Gene|MXD2|MXI1	Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. The protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. MXI1 maps to a region of chromosome 10 that is deleted in some cases of prostate cancer. (LocusLink and OMIM)
C24620	MYBBP1A_Gene	Gene_with_Unknown_or_Unclassified_Function	MYBBP1A Gene|MYB Binding Protein (P160) 1A Gene|MYBBP1A|P160|PAP2	Widely expressed as a 4.5-kb transcript, human MYBBP1A Gene encodes 1328-aa 149-kDa MYB Binding Protein 1A, containing a central acidic region, C-terminal basic amino acid repeats, and potential leucine charged domain motifs throughout. MYBBP1A shares approximately 80% amino acid sequence similarity with the mouse and rat Mybbp1a homolog, a ubiquitous nucleolar protein that specifically interacts with leucine zipper motifs in the MYB negative regulatory domain (NRD) to modulate MYB hemopoietic cell proliferation and differentiation activity. Disruption of the MYB NRD leucine zipper motif, increases MYB DNA binding, transactivation, and transformation. (NCI)
C24621	N33_Gene	Gene_with_Unknown_or_Unclassified_Function	TUSC3 Gene|D8S1992|MGC13453|N33|TUSC3|Tumor Suppressor Candidate 3 Gene	Expressed in most nonlymphoid tissues including prostate, lung, liver, and colon, human N33 Gene (OST3 Family) encodes 348-aa 40-kDa N33 Protein, a potential integral membrane protein.  This gene is a candidate tumor suppressor gene. It is located within a homozygously deleted region of a metastatic prostate cancer.
C24622	NAG_Gene	Gene_with_Unknown_or_Unclassified_Function	NAG Gene|DKFZP586G1219|NAG|Neuroblastoma-Amplified Protein Gene	Expressed in adult and fetal tissues, 52-exon 420-kb human NAG Gene encodes 1352-aa 153-kDa and 2371-aa 268-kDa isoforms of Neuroblastoma-Amplified Protein. The NAG 5-prime region contains a CpG island, a TATA box, a CCAAT box, and SP1, OCT1, and MYC binding sites. The 1,352-aa protein contains a C-terminal leucine zipper domain and a ribosomal protein S14 signature domain. In addition, the 2,371-aa protein contains an N-terminal leucine zipper motif, 3 putative transmembrane helices, an endoplasmic reticulum signal sequence, and 2 peroxisomal targeting signals. NAG has 2 clusters of nuclear localization signals, one in the N-terminus of the longer variant and the other in the common C-terminus. NAG shares 83 to 86% identity with orthologous mammalian proteins. The C-terminal leucine zipper and ribosomal S14 motif are not conserved in plant and nematode proteins. (NCI)
C24623	NCK2_Gene	Adaptor_Signaling_Protein_Gene	NCK2 Gene|GRB4|NCK Adaptor Protein 2 Gene|NCK2|NCKBeta	Human NCK2 Gene encodes ubiquitous 380-aa 43-kDa cytoplasmic NCK Adaptor Protein 2, containing 1 SH2 domain and 3 SH3 domains, and associates with tyrosine-phosphorylated growth factor receptors or their substrates. NCK2 interacts with PINCH and DOCK1. NCK2 shares 68% amino acid identity with NCK-alpha; most differences occur outside the SH2/SH3 domains. NCK2 associates with PDGF and EGF receptors via p62DOK and inhibits DNA synthesis. NCK2 binds to B ephrin cytoplasmic domains in a phosphotyrosine-dependent manner. NCK2-dependent (SH2 domain) B ephrin signaling increases FAK activity, redistributes paxillin, inhibits focal adhesions, and disassembles F-actin fibers. NCK2 SH3 domains bind proteins implicated in cytoskeletal regulation: CAP/ponsin, ABI1, dynamin, PAK1, HNRNPK, and axin. (NCI)
C24624	NCYM_Gene	Transcription_Coactivator_Gene	MYCNOS Gene|MYCNOS|NCYM|V-Myc Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived (Avian) Opposite Strand Gene	Expressed in fetal brain, lung, liver, and kidney, human NCYM Gene encodes 109-aa 12-kDa DNA-Binding Transcriptional Activator NCYM, containing a helix-loop-helix motif and a basic region. NCYM appears to function as a DNA-binding protein during normal fetal development and is implicated in the pathogenesis of human tumors. The NCYM transcription unit is located on the opposite strand to NMYC, with extensive overlap between the 5-prime ends of the two units. NMYC and NCYM appear to be coregulated under basal growth conditions and in response to retinoic acid. (NCI)
C24625	NDRG1_Gene	Regulatory_Gene	NDRG1 Gene|CAP43|CMT4D|DRG1|HMSNL|N-myc Downstream Regulated Gene 1 Gene|NDR1|NDRG1|NMSL|PROXY1|RTP|TDD5	Expressed most prominently in placenta, prostate, kidney, small intestine, and ovary, human NDRG1 Gene (NDRG Family, Alpha/Beta Hydrolase Superfamily) encodes ubiquitous cytoplasmic N-Myc Downstream Regulated Protein 1, also associated with the plasma membrane and nucleus. Downregulated by NMYC and rapidly induced by okadaic acid, a serine/threonine phosphatase inhibitor, increased NDRG1 levels are induced by an elevation of free intracellular calcium ion; cells that border lumenae show highest expression. Involved in stress responses, hormone responses, cell growth, and differentiation, NDRG1 may have a growth inhibitory role. (NCI)
C24626	NEO1_Gene	Membrane_Protein_Gene	NEO1 Gene|NEO1|NGN|Neogenin Homolog 1 (Chicken) Gene	Homolog of the chicken gene neogenin, which is induced in neural cells immediately before cell cycle withdrawal and terminal differentiation. The gene is infrequently affected by alterations in cancer and no alterations in expression were observed in more than 50 cancers studied, including glioblastoma, medulloblastoma, neuroblastoma, colorectal, breast, cervical, and pancreatic cancer cell lines, and xenografts. (from OMIM)
C24627	NEURL_Gene	Regulatory_Gene	NEURL Gene|NEURL|Neuralized-Like (Drosophila) Gene|RNF67|h-neu	Expressed as a 4.2-kb mRNA in brain, human NEURL Gene encodes 574-aa 62-kDa Neuralized-like Protein, a homolog of neuralized (neu: Drosophila, C. elegans) that appears to be involved in embryonic neurogenic cell fate determination in the central nervous system. Like neu, NEURL contains 2 NHRs (neuralized homology repeats) and a C-terminal RING finger. (NCI)
C24628	NGFR_Gene	Growth_Factor_Receptor_Gene	NGFR Gene|NGFR|Nerve Growth Factor Receptor (TNFR Superfamily, Member 16) Gene|TNFRSF16|p75(NTR)	This gene encodes nerve growth factor receptor (NGFR). NGFR was the first member of the large superfamily of tumor necrosis factor receptors. The identification of this superfamily helped elucidate some of the biologic functions of NGFR, including its ultimate involvement in the nuclear factor kappa-B (NFKB) and apoptosis pathways. As a monomer, NGFR binds NGF with low affinity. Higher affinity binding is achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1), TRKB (NTRK2), and TRKC (NTRK3). (OMIM)
C24629	NGFRAP1_Gene	Signaling_Pathway_Gene	NGFRAP1 Gene|BEX3|Bex|DXS6984E|HGR74|NADE|NGFRAP1|Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 Gene	Cloned by its ability to interact with the death domain of nerve growth factor receptor. Likely to be involved in nerve growth factor-mediated apoptosis. (from OMIM)
C24630	NKX2H_Gene	Homeobox_Gene	NKX2-8 Gene|NK2 Transcription Factor Related, Locus 8 (Drosophila) Gene|NKX2-8|NKX2.8|NKX2H|Nkx2-9	Expressed as a 1.6-kb mRNA in fetal liver and located about 80-kb upstream of PAX9 (oriented head to head), human NKX2H Gene (NK2 Homeobox Family) encodes 239-aa 26-kDa Homeobox Protein NK2 Homolog H, a basic protein related to nk-2 (Drosophila) homeobox transcription factor and containing a homeobox domain and a conserved peptide of nk-2-related proteins. A likely component of PCF (an AFP developmental regulator), NKX2H binds to the AFP gene promoter-linked coupling element (PCE) and activates transcription. (NCI)
C24631	NKX3-1_Gene	Homeobox_Gene	NKX3-1 Gene|NK3 Transcription Factor Related, Locus 1 (Drosophila) Gene|NKX3-1|NKX3.1|NKX3A	Expressed in a largely prostate-specific and androgen-regulated manner, human NKX3-1 Gene (NK-3 Homeobox Family) encodes nuclear Homeobox Protein NKX3A, a transcription factor containing 1 homeobox domain that preferentially binds the consensus sequence TAAGT[AG] and may regulate proliferation of glandular epithelium. NKX3A may interact with SRF and can also behave as a transcriptional repressor. (NCI)
C24632	NMA_Gene	Gene_with_Unknown_or_Unclassified_Function	BAMBI Gene|BAMBI|BMP and Activin Membrane-Bound Inhibitor Homolog|BMP and Activin Membrane-Bound Inhibitor Homolog (Xenopus Laevis) Gene|NMA	Expressed in melanocytes, kidney, placenta, spleen, liver, prostate, and gut, 3-exon human NMA Gene encodes 260-aa 29-kDa (precursor) Putative Transmembrane Protein NMA, containing a signal sequence and a transmembrane domain. (NCI)
C24633	NMBR_Gene	G_Protein-Coupled_Receptor_Gene	NMBR Gene|NMBR|Neuromedin B Receptor Gene	A mammalian homolog of amphibian bombesin, Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue. (from OMIM)
C24634	NMI_Gene	Ligand_Binding_Protein_Gene	NMI Gene|N-MYC (and STAT) Interactor Gene|NMI	NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. (LocusLink)
C24635	NMU_Gene	Peptide_Hormone_Gene	NMU Gene|NMU|Neuromedin U Gene	Expressed throughout the enteric and central nervous systems, human NMU Gene (NMU Family) encodes 174-aa 20-kDa (precursor) secreted Neuromedin U (25-aa), a potent neuropeptide ligand of G Protein-Coupled Receptor 66 and Neuromedin U Receptor 2 (a GPCR) that stimulates smooth muscle contractions of the ileum, urinary bladder, and uterus, increases blood pressure, alters ion transport in the gut, controls local blood flow, and regulates adrenocortical function. The precursor contains a signal peptide and 4 paired basic residues, putative proteolytic processing sites, indicating that the precursor may generate 3 peptides, including NMU located near the C terminus. (NCI)
C24636	NOTCH1_Gene	Receptor_Gene	NOTCH1 Gene|NOTCH1|Notch Homolog 1, Translocation-Associated (Drosophila) Gene|TAN1|hN1	Expressed in adult/fetal tissues, human NOTCH1 Gene (Notch Family) encodes 2556-aa 273-kDa phosphorylated type 1 transmembrane Notch Homolog 1, containing 36 extracellular EGF domains, 3 Lin/Notch repeats, and multiple intracellular domains, including 5 ANK repeats. Cleaved by a Golgi furin-like convertase, cell surface Notch protein is a disulfide linked N-/C-terminal heterodimeric receptor for membrane-bound Jagged1, Jagged2, Delta1, and Serrate on adjacent cells that activates an conserved intercellular signaling pathway (lateral inhibition) to regulate cell-fate determination, differentiation, proliferation, and apoptotic programs. Activated Notch cleavage by TACE and presenilin dependent gamma-secretase releases the intracellular domain to form a transcription complex with RBP-J kappa to activate enhancer of split genes. NOTCH1 interacts with DTX1 and DTX2 and may regulate thymic lymphocyte maturation. (NCI)
C24637	NPR2_Gene	Receptor_Gene	NPR2 Gene|ANPRB|GUC2B|NPR2|NPRB|NPRBi|Natriuretic Peptide Receptor B/Guanylate Cyclase B (Atrionatriuretic Peptide Receptor B) Gene	Expressed by heart and vasculature, human NPR2 Gene (Guanylyl Cyclase Family) encodes type I integral membrane protein Natriuretic Peptide Receptor B, the primary receptor for C-type natriuretic peptides that cause natriuresis, sodium excretion in the urine. NPR2 contains an extracellular ligand-binding domain, a membrane-spanning region, and an intracellular protein kinase homology domain, oligomerizing helical hinge region, and a C-terminal guanylyl cyclase catalytic domain activated upon receptor ligand binding. NPR2 seems to be more effectively stimulated by BNP than by ANP. NPR1 and NPR2 are ANP receptors with guanylate cyclase activity; NPR3 is probably responsible for ANP clearance from the circulation without a role in signal transduction. (NCI)
C24638	NR1_Gene	Oxidoreductase_Gene	NDOR1 Gene|NADPH Dependent Diflavin Oxidoreductase 1 Gene|NDOR1|NR1	Broadly expressed as 3.0-kb and 6.0-kb transcripts, human NR1 Gene (FNR Family) encodes 597-aa 67-kDa cytoplasmic NADPH-Dependent FMN and FAD Containing Oxidoreductase, an enzyme homologous to cytochrome P-450 reductase that binds FMN, FAD, and NADPH cofactors, reduces cytochrome c, and metabolizes electron acceptors doxorubicin, menadione, and potassium ferricyanide. NR1 shares 41 to 44% similarity with nitric oxide synthase-2, methionine synthase transferase, and P-450 reductase. It may play a role in metabolic activation of bioreductive anticancer drugs and other chemicals activated by 1-electron reduction. (NCI)
C24639	NRBP_Gene	Gene_with_Unknown_or_Unclassified_Function	NRBP Gene|BCON3|MADM|MUDPNP|NRBP|Nuclear Receptor Binding Protein Gene	Expressed as a 2.4-kb transcript, human NRBP Gene encodes ubiquitous 535-aa 60-kDa Nuclear Receptor Binding Protein, a putative adaptor protein containing 2 putative nuclear receptor-binding motifs, a putative binding domain for SH2 domain-containing proteins, a kinase-like domain, a bipartite nuclear localization signal, and 3 PEST sequences. Mouse and rat NRBP homologs exhibit 91% and 89% identity with NRBP. (NCI)
C24640	NRCAM_Gene	Cell_Adhesion_Molecule_Gene	NRCAM Gene|KIAA0343|NRCAM|Neuronal Cell Adhesion Molecule Gene	The cell adhesion molecules (CAMs) are a subset of the immunoglobin (Ig) superfamily found in the nervous systems of both vertebrates and invertebrates. They are usually surface membrane proteins with multiple Ig domains at their N termini followed by several fibronectin type III repeats and either a transmembrane intracellular domain or a glycophosphatidylinositol-linked membrane anchor at the C terminus. (Lane et al., 1996 [PubMed 8812479])
C24641	NRG2_Gene	Growth_Factor_Gene	NRG2 Gene|DON-1|DON1|NRG2|NTAK|Neuregulin 2 Gene	Neuregulin 2 (NRG2) is a novel member of the neuregulin family of growth and differentiation factors. Through interaction with the Erbb family of receptors, NRG2 induces the growth and differentiation of epithelial, neuronal, glial, and other types of cells. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1 (NRG1), another member of the neuregulin family of ligands. NRG1 and NRG2 mediate distinct biological processes by acting at different sites in tissues and eliciting different biological responses in cells. There are six NRG2 alternatively spliced transcripts which are variable between the epidermal growth factor-like (EGF-like) and the transmembrane domains. The gene is located close to the region for demyelinating Charcot-Marie-Tooth disease locus, but is not responsible for this disease. (LocusLink)
C24642	NRP1_Gene	Receptor_Gene	NRP1 Gene|NRP|NRP1|Neuropilin 1 Gene|VEGF165R	Human NRP1 Gene (Neuropilin Family) encodes Neuropilin 1, containing 1 MAM, 2 F5/8 type C, and 2 CUB domains. Found in embryonic nervous system, and adult heart, placenta lung, liver, skeletal muscle, kidney, and pancreas, type I membrane-bound 923-aa 103-kDa (precursor) isoform 1, expressed by blood vessels, acts as a receptor in cardiovascular development, angiogenesis, formation of neuronal circuits, and organogenesis. Binding to semaphorin 3A, PLGF-2, VEGF-165, and VEGF-B, Isoform 1 appears to mediate chemorepulsion by semaphorins, to increase VEGF-165 binding to KDR, and to regulate VEGF-induced angiogenesis. Expressed in hepatocytes and kidney distal/proximal tubules, secreted 644-aa isoform 2 may bind semaphorins and induce apoptosis by sequestering VEGF-165; it has an adverse effect on blood vessel integrity. Expression of isoforms 1 and 2 does not seem to overlap. (NCI)
C24643	NRTN_Gene	Transforming_Growth_Factor-Beta_Family_Gene	NRTN Gene|NRTN|NTN|Neurturin Gene	This gene encodes neurturin, a member of the TGF-beta subfamily. This gene signals through RET and a GPI-linked co-receptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. (LocusLink)
C24644	NTF3_Gene	Growth_Factor_Gene	NTF3 Gene|HDNF|NGF-2|NT3|NTF3|Neurotrophin 3 Gene	This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. This gene is closely related to both nerve growth factor and brain-derived neurotrophic factor. The protein encoded by this gene may be involved in the maintenance of the adult nervous system, and affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of NTF3 is identical in all mammals examined including human, pig, rat and mouse. (LocusLink)
C24645	NTN1_Gene	Gene_with_Unknown_or_Unclassified_Function	NTN1 Gene|NTN1|NTN1L|Netrin 1 Gene	Widely expressed in adult tissues (highest in heart, small intestine, colon, liver, and prostate), human NTN1 Gene (Laminin Family) encodes 604-aa 68-kDa (precursor) Netrin 1, containing an N-terminal laminin domain, 3 laminin EGF-like domains, and an NTR domain. NTN1 binds to DCC and is thought to be involved in CNS and peripheral motor axon guidance and cell migration during development. Defects in NTN1 are associated with some neuroblastomas. (NCI)
C24646	NTRK2_Gene	Receptor_Tyrosine_Kinase_Gene	NTRK2 Gene|NTRK2|Neurotrophic Tyrosine Kinase, Receptor, Type 2 Gene|TRKB	Widely expressed (mainly neural tissue), human NTRK2 Gene (IR Tyr Kinase Family) encodes alternative isoforms TRKB (822-aa 92-kDa precursor), TRKB-T1 (477-aa), and TRKB-T-SHC (537-aa) of Neurotrophic Tyrosine Kinase Receptor Type 2, a type I membrane receptor for BDNF, NTF3, and NTF4/5, but not NGF, involved in development and/or maintenance of the nervous system that contains 2 LRR repeats and 2 Ig-like C2-type domains. Monomeric (low affinity) and dimeric (high affinity) forms appear to exist in dynamic equilibrium. Known substrates for TRK receptors are SHC, PI-3 kinase, and PLC-gamma-1. NTRK2 undergoes ligand-mediated auto-phosphorylation. (NCI)
C24647	NTRK3_Gene	Receptor_Tyrosine_Kinase_Gene	NTRK3 Gene|NTRK3|Neurotrophic Tyrosine Kinase, Receptor, Type 2 Gene|TRKC	Widely expressed (mainly nervous tissue), human NTRK3 Gene (IR Tyr Kinase Family) encodes alternative isoforms A (839-aa 94-kDa precursor), B (612-aa), C (825-aa), and D (830-aa) of Neurotrophic Tyrosine Kinase Receptor Type 3, a type I membrane receptor for NTF3 containing 2 LRR repeats and 2 Ig-like C2-type domains. Monomeric (low affinity) and dimeric (high affinity) forms appear to exist in dynamic equilibrium and the isoforms do not have identical signaling properties. Known substrates for TRK receptors are SHC, PI-3 kinase, and PLC-gamma-1. NTRK3 undergoes ligand-mediated auto-phosphorylation. (NCI)
C24648	NUMA1_Gene	Regulatory_Gene	NUMA1 Gene|NUMA|NUMA1|Nuclear Mitotic Apparatus Protein 1 Gene	This gene encodes a structural component of the nucleus; predicted role in nuclear reassembly in late mitosis; contains a predicted coiled-coil domain.(LocusLink)
C24649	NUP214_Gene	Nucleoporin_Gene	NUP214 Gene|CAIN|CAN|D9S46E|KIAA0023|N214|NUP214	Expressed in thymus, spleen, bone marrow, kidney, brain, and testis, human NUP214 Gene (FG-Repeat NUP Family) encodes 2090-aa 214-kDa homodimeric Nuclear Pore Complex Protein NUP214, likely glycosylated, containing F-G repeats, and associated with cytoplasmic filaments and the cytoplasmic face of the nuclear pore complex. NUP214 is required for proper cell cycle progression and, as a nuclear pore component, may regulate nucleocytoplasmic transport by serving as a docking site in receptor-mediated nuclear import. NUP214 interacts with DDX19 and NUP88. Involved in some cases of leukemia, chromosomal translocation t(6;9)(p23;q34) results in a DEK-NUP214 fusion gene, while chromosomal translocation t(6;9)(q21;q34.1) involves a NUP214/SET gene fusion. (NCI)
C24650	OR1G1_Gene	Receptor_Gene	OR1G1 Gene|OR17-130|OR17-209|OR1G1|OR1G2|Olfactory Receptor, Family 1, Subfamily G, Member 1 Gene	Human OR1G1 Gene (GPCR1 Family) encodes 313-aa 35-kDa integral membrane protein Olfactory Receptor 1G1, a putative odorant receptor. (NCI)
C24651	OS4_Gene	Gene_with_Unknown_or_Unclassified_Function	CTDSP2 Gene|CTD (Carboxy-Terminal Domain, RNA Polymerase II, Polypeptide A) Small Phosphatase 2 Gene|CTDSP2|OS4|SCP2	Ubiquitously expressed (highest in pancreas, lowest in liver) human OS4 Gene (NIF Family) encodes 283-aa 32-kDa Nuclear LIM Interactor-Interacting Factor 2, a phosphatase that may interact with LDB1. (NCI)
C24652	OSMR_Gene	Cytokine_Receptor_Gene	OSMR Gene|OSMR|OSMRB|Oncostatin M Receptor Gene	Human OSMR Gene encodes 111-kDa 979-aa Oncostatin-M Specific Receptor Beta Subunit, a subunit with gp130 (a common subunit of IL6 family receptors) for a heterodimeric OSM receptor complex. OSMR contains characteristic motifs of the hematopoietin receptor family. OSM may bind to the gp130 subunit. (NCI)
C24653	P37NB_Gene	Gene_with_Unknown_or_Unclassified_Function	LRRC17 Gene|LRRC17|Leucine Rich Repeat Containing 17 Gene|P37NB	Human P37NB Gene encodes 313-aa 37-kDa Leucine Rich Repeat Containing Protein 17, of unknown function. (NCI)
C24654	PAG_Gene	Adaptor_Signaling_Protein_Gene	PAG Gene|PAG|Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains Gene	Human PAG Gene encodes ubiquitous 432-aa 47-kDa Phosphoprotein Associated with GEMs, a type III plasma transmembrane adaptor protein located predominantly in membrane rafts (GEMs), associated with FYN and CSK tyrosine kinase, and thought to be involved in T cell activation and immunoreceptor signal transduction. PAG contains a 16-aa extracellular domain, a transmembrane domain, a putative palmitoylation site, and a 397-aa cytoplasmic tail with 9 potential tyrosine phosphorylation sites, ITAM-like motifs, and multiple putative casein kinase II and protein kinase C phosphorylation sites. Two Pro-rich sequences may bind to SH3 domains. PAG recruits CSK to the plasma membrane, independent of FYN. After T-cell activation, association with CSK, but not FYN, decreases. PAG/CSK may increase the signaling threshold for initiating an immune response, keeping lymphocytes in a resting state. (NCI)
C24655	PAK6_Gene	Serine-Threonine_Protein_Kinase_Gene	PAK6 Gene|PAK5|PAK6|p21(CDKN1A)-Activated Kinase 6 Gene|p21-Activated Kinase 6 Gene	This gene encodes a protein that shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The p21-activated protein kinase 6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. (LocusLink)
C24656	PARD6A_Gene	Ligand_Binding_Protein_Gene	PARD6A Gene|PAR-6|PAR-6A|PAR6Alpha|PARD6A|Par-6 Partitioning Defective 6 Homolog Alpha (C.elegans) Gene|TAX40|TIP-40	The PARD6A gene encodes Tax Interaction Protein 40, which belongs to the PAR6 family. It is an adapter protein involved in asymetrical cell division and cell polarization processes. It is probably involved in the formation of epithelial tight junctions. Its association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. (from Swiss-Prot)
C24657	PAWR_Gene	Transcription_Corepressor_Gene	PAWR Gene|PAR4|PAWR|PRKC, Apoptosis, WT1, Regulator Gene|par-4	The tumor suppressor WT1 represses and activates transcription. Apoptosis response protein is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. Apoptosis response protein is specifically upregulated during apoptosis of prostate cells. (LocusLink)
C24658	PAX3_Gene	Transcription_Coactivator_Gene	PAX3 Gene|CDHS|HUP2|PAX3|Paired Box Gene 3|Paired Box Gene 3 (Waardenburg Syndrome 1) Gene|Paired Domain Gene HuP2|WS1	The PAX3 gene encodes Paired Box Protein Pax-3, which is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. (from LocusLink)
C24659	PAX5_Gene	Transcription_Coactivator_Gene	PAX5 Gene|BSAP|PAX5|Paired Box Gene 5 (B-Cell Lineage Specific Activator) Gene	The PAX5 gene encodes Paired Box 5, a member of the paired box (PAX) family of transcription factors. Paired Box 5 is expressed at early stages of B-cell differentiation. Its expression is also detected in developing CNS and testis. Paired Box 5 may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. This gene is located in chromosome 9p13 region, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoters. Deregulation of PAX5 gene transcription may contribute to the pathogenesis of these lymphomas. (from LocusLink)
C24660	PAX7_Gene	Transcription_Coactivator_Gene	PAX7 Gene|HUP1|PAX7|Paired Box Gene 7|Paired Box Homeotic Gene 7|Paired Domain Gene 7	The PAX7 gene encodes Paired Box Protein Pax-7, which is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of Paired Box Protein Pax-7 is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Alternative splicing in this gene has produced two known products but the biological significance of the variants is unknown. (from LocusLink)
C24661	PBEF_Gene	Cytokine_Gene	PBEF Gene|PBEF|PBEF1|Pre-B-Cell Colony Enhancing Factor 1 Gene	The PBEF gene encodes Pre-B-Cell Colony-Enhancing Factor, a cytokine that acts on early B-lineage precursor cells by enhancing the effect of IL-7 and SCF on pre-B-cell colony formation. This protein is secreted and expressed in large amounts in bone marrow, liver tissue, and muscle. It is also present in heart, placenta, lung, and kidney tissues. (from LocusLink)
C24662	PBX3_Gene	Ligand_Binding_Protein_Gene	PBX3 Gene|PBX3|Pre-B-Cell Leukemia Transcription Factor 3 Gene	The PBX3 gene encodes Pre-B-Cell Leukemia Transcription Factor 3. This protein is a transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Four alternative products result from alternative splicing. (from LocusLink)
C24663	PCTK1_Gene	Serine-Threonine_Protein_Kinase_Gene	PCTK1 Gene|PCTAIRE Protein Kinase 1 Gene|PCTAIRE1|PCTGAIRE|PCTK1	The PCTK1 gene encodes PCTAIRE Protein Kinase 1, which belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. This protein may play a role in signal transduction cascades in terminally differentiated cells. The PCTK1 gene is thought to escape X inactivation. There are three alternatively spliced transcript variants described for this gene. (from LocusLink)
C24664	PDC_Gene	Signaling_Pathway_Gene	PDC Gene|MEKA|PDC|PHD|PhLOP|PhLP1|Phosducin Gene	The PDC gene encodes Phosducin, a phosphoprotein that is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. (from LocusLink)
C24665	PDGFA_Gene	Growth_Factor_Gene	PDGFA Gene|PDGF1|PDGFA|Platelet-Derived Growth Factor Alpha Polypeptide Gene	Expressed as 2 alternative isoforms in platelets, human PDGFA Gene (PDGF/VEGF Family) encodes Platelet-Derived Growth Factor Alpha, a mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released by platelets upon wounding to stimulate adjacent cell growth. PDGFA can exist as either antiparallel disulfide-linked homodimers or heterodimers with Platelet-Derived Growth Factor Beta. A long PDGFA isoform contains a basic insert that acts as a cell retention signal. A-A, B-B, and A-B, dimers can bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. (NCI)
C24666	PDGFRA_Gene	Receptor_Tyrosine_Kinase_Gene	PDGFRA Gene|CD140A|PDGFR2|PDGFRA|Platelet-Derived Growth Factor Receptor, Alpha Polypeptide Gene	The PDGFRA gene encodes Platelet-Derived Growth Factor Receptor, Alpha Polypeptide, which is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. (from LocusLink)
C24667	PDGFRB_Gene	Receptor_Tyrosine_Kinase_Gene	PDGFRB Gene|CD140B|JTK12|PDGF-R-Beta|PDGFR|PDGFR1|PDGFRB|Platelet-Derived Growth Factor Receptor, Beta Polypeptide Gene	The PDGFRB gene encodes Platelet-Derived Growth Factor Receptor, Beta Polypeptide, which is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETS, leukemia gene, results in chronic myelomonocytic leukemia. (from LocusLink)
C24668	PDGFRL_Gene	Gene_with_Unknown_or_Unclassified_Function	PDGFRL Gene|PDGFRL|PDGRL|PRLTS|Platelet-Derived Growth Factor Receptor-Like Gene	The PDGFRL gene encodes Platelet-Derived Growth Factor Receptor-Like Protein, which has significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. (from LocusLink)
C24669	PDPK1_Gene	Serine-Threonine_Protein_Kinase_Gene	PDPK1 Gene|3-Phosphoinositide Dependent Protein Kinase-1 Gene|PDK1|PDPK1|PRO0461	The PDPK1 gene encodes 3-Phosphoinositide Dependent Protein Kinase-1, which belongs to the Ser/Thr family of protein kinases. This protein phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, p70S6K and p90S6K/RSK. It may play a general role in signaling processes and in development (by similarity). It becomes cytoplasmic and membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane. Three isoforms exist from alternative splicing and Isoform 3 is catalytically inactive. (from LocusLink)
C24670	PGF_Gene	Growth_Factor_Gene	PGF Gene|PGF|PLGF-2|Parathyroid Hormone-Like Hormone Gene|PlGF|Placental Growth Factor Gene|Placental Growth Factor, Vascular Endothelial Growth Factor-Related Protein Gene	The PGF gene at 14q24-q31 encodes Placental Growth Factor, which belongs to the PDGF/VEGF growth factor family. Placental Growth Factor is active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. Three isoforms exist from alternative splicing. (From LocusLink)
C24671	PIAS3_Gene	Signaling_Pathway_Gene	PIAS3 Gene|PI4K-Beta|PIAS3|Protein Inhibitor of Activated STAT, 3 Gene	Widely expressed, human PIAS3 Gene encodes 619-aa 67-kDa Protein Inhibitor of Activated STAT3, containing a SAP domain and a MIZ-type zinc finger, that specifically inhibits the DNA-binding signaling activity of activated STAT3, a latent cytoplasmic transcription factor that becomes activated by tyrosine phosphorylation in response to cytokine stimulation. PIAS3 shares 83% identity with mouse Pias3, approximately 55% identity with PIAS1 and PIASX proteins, and 39% identity with PIASY. Independent of STAT3 binding and by direct binding, PIAS3 also appears to block MITF DNA-binding and transcription activity. (NCI)
C24672	PIK3CB_Gene	Phosphoinositol_Kinase_Family_Gene	PIK3CB Gene|PIK3C1|PIK3CB|Phosphoinositide-3-Kinase, Catalytic, Beta Polypeptide Gene|p110-Beta	The PIK3CB gene encodes Phosphoinositide-3-Kinase, Catalytic, Beta Polypeptide, which belongs to the PI3/PI4-kinase family. Phosphatidylinositol 3 Kinase is a heterodimer of a P110 (catalytic) and a P85 (regulatory) subunit. It phosphorylates PTDINS, PTDINS4P and PTDINS(4,5)P2 with a preference for PTDINS(4,5)P2. (from Swiss-Prot)
C24673	PIK3CG_Gene	Phosphoinositol_Kinase_Family_Gene	PIK3CG Gene|PI3CG|PI3K|PI3KGamma|PIK3|PIK3CG|Phosphoinositide-3-Kinase, Catalytic, Gamma Polypeptide Gene	The PIK3CG gene encodes Phosphoinositide-3-Kinase, Catalytic, Gamma Polypeptide, which belongs to the PI3/PI4-kinase family of proteins. This protein is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. (from LocusLink)
C24674	PIK3R3_Gene	Phosphoinositol_Kinase_Family_Gene	PIK3R3 Gene|PIK3R3|Phosphoinositide-3-Kinase, Regulatory Subunit 3 (p55, Gamma) Gene|p55-Gamma	The PIK3CG gene encodes Phosphoinositide-3-Kinase, Regulatory Subunit, Polypeptide 3, which binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. (from Swiss-Prot)
C24675	PIK4CB_Gene	Phosphoinositol_Kinase_Family_Gene	PIK4CB Gene|PI3CGPI4KBeta|PI4K-Beta|PI4KB|PIK4CB	The PIK4CB gene encodes Phosphoinositide-4-Kinase, Catalytic, Beta Polypeptide, which belongs to the PI3/PI4-kinase family. This protein phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). It may regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Its enzymatic activity is inhibited by wortmannin. This protein is found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum, and recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2) on the Golgi complex. Two named isoforms exist resulting from alternative splicing. (from Swiss-Prot)
C24676	PIP5K2A_Gene	Phosphoinositol_Kinase_Family_Gene	PIP5K2A Gene|PIP5K2A|PIP5KII-Alpha|PIPK	Expressed ubiquitously (high in brain), human PIP5K2A Gene (PtdIns(4)P-5-Kinase Family) encodes 406-aa 46-kDa Phosphatidylinositol-4-Phosphate 5-Kinase Type II Alpha, a likely homodimer that catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-biphosphate, the precursor to second messengers of phosphoinositide signal transduction pathways involved in regulation of secretion, cell proliferation, differentiation, and motility. PIP5K2A does not show homology to other kinases, but the protein does exhibit kinase activity. (NCI)
C24677	PIP5K2B_Gene	Phosphoinositol_Kinase_Family_Gene	PIP5K2B Gene|PIP5K2B|PIP5KIIB|Phosphatidylinositol-4-Phosphate 5-Kinase, Type II, Beta Gene	The protein encoded by this gene catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate. This gene is a member of the phosphatidylinositol-4-phosphate 5-kinase family. The encoded protein sequence does not show similarity to other kinases, but the protein does exhibit kinase activity. Additionally, the encoded protein interacts with p55 TNF receptor. Two transcript variants encoding different isoforms have been found for this gene. (LocusLink)
C24678	PLA2G2A_Gene	Esterase_Gene	PLA2G2A Gene|MOM1|PLA2B|PLA2G2A|PLA2L|PLA2S|PLAS1|Phospholipase A2, Group IIA (Platelets, Synovial Fluid) Gene	Expressed in many cells, human PLA2G2A Gene (PLA2 Type II Family) encodes identical membrane-bound and secreted forms of 144-aa 16-kDa (precursor) Phospholipase A2 Group IIA, which catalyzes calcium-dependent hydrolysis of sn-2 fatty acid acyl ester bonds in 3-sn-phosphoglycerides, releasing free fatty acids and lysophospholipids. Thought to regulate biomembrane phospholipid metabolism and eicosanoid biosynthesis, PLA2G2A is likely involved in a variety of cellular processes, including production of precursors for inflammatory reactions. (NCI)
C24679	PLAB_Gene	Transforming_Growth_Factor-Beta_Family_Gene	GDF15 Gene|GDF-15|GDF15|Growth Differentiation Factor 15 Gene|MIC-1|MIC1|NAG-1|PDF|PLAB|PLAB Gene|PTGFB	Expressed (1.35-kb mRNA) in activated, but not resting, macrophages and in placenta, prostate, colon, and kidney, 2-exon human PLAB Gene (BMP/TGF-Beta Family) encodes 308-aa 34-kDa (precursor) Placental TGF-Beta, processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in a disulfide-linked homodimeric secreted mature protein of 224 amino acids. PLAB regulates tissue differentiation and maintenance and reduces the growth of granulocytes and macrophages. Unlike most TGFB superfamily members, in which the amino acid sequence is completely conserved, PLAB shares only 70% amino acid identity with its rodent counterparts. (NCI)
C24680	PLAGL1_Gene	Ligand_Binding_Protein_Gene	PLAGL1 Gene|LOT1|PLAGL1|Pleiomorphic Adenoma Gene-Like 1 Gene|ZAC|ZAC1	About 60-kb downstream of NV149 and widely expressed (only from paternal allele), human PLAGL1 Gene (Krueppel Family) encodes 411-aa 45-kDa DNA-binding transcriptional activator Pleomorphic Adenoma-Like Protein 1, containing 7 C2H2-type zinc fingers, that inhibits cell proliferation through induction of the p53 apoptosis and cell cycle arrest pathways. PLAGL1 also regulates pituitary adenylate cyclase-activating polypeptide type 1 receptor, a potent insulin secretagogue and mediator of autocrine control of insulin secretion in the pancreatic islets. (NCI)
C24681	PLAUR_Gene	Receptor_Gene	PLAUR Gene|CD87|PLAUR|Plasminogen Activator, Urokinase Receptor Gene|UPAR|URKR	High affinity cellular receptor for urokinase plasminogen activator (uPA).  Plays a role in plasminogen activation by facilitating the conversion of uPA to an enzymatically active form anchored to the cell membrane, where plasminogen activation occurs.  Affects tissue remodeling (surface proteolysis, cell adhesion, cell migration), and cancer invasion.
C24682	PLCB3_Gene	Esterase_Gene	PLCB3 Gene|PLCB3|Phospholipase C, Beta 3 (Phosphatidylinositol-Specific) Gene	Expressed in many tissues (4.4-kb mRNA), 31-exon 17-kb human PLCB3 Gene encodes 1234-aa 139-kDa membrane-bound Phospholipase C Beta 3, containing a PI-PLC X-box catalytic domain, a PI-PLC Y-box catalytic domain, and a C2 domain. Activated in response to stimulation by hormones, growth factors, neurotransmitters, and other ligands, PLCB3 is a key enzyme in initiating receptor-mediated signal transduction by mediating production of DAG and IP3 second messengers. (NCI)
C24683	PLK_Gene	Serine-Threonine_Protein_Kinase_Gene	PLK1 Gene|PLK|PLK Gene|Polo-Like Kinase 1 (Drosophila) Gene|STPK13	Induced by growth-stimulating agents in placenta and colon, human PLK Gene (CDC5/Polo Ser/Thr Kinase Family) encodes conserved 603-aa 68-kDa nuclear Polo-Like Kinase, a serine/threonine kinase containing 2 POLO box domains and localized to centrosomes, centromeres/kinetochores, and the spindle midzone that accumulates during S, is maximal during G2/M, and declines throughout G1. Implicated in organization and function of the mitotic apparatus and required for spermatogenesis, PLK phosphorylation of the cyclin B1 nuclear export signal may target mitosis-promoting factor to the nucleus during prophase, which is essential for induction and coordination of M-phase.  (NCI)
C24684	PLU-1_Gene	Ligand_Binding_Protein_Gene	JARID1B Gene|JARID1B|Jumonji, AT Rich Interactive Domain 1B (RBP2-Like) Gene|PLU-1|PLU-1 Gene|PUT1|RBBP2H1A	Widely expressed as 6- and 7-kb transcripts at varying levels (highest in Sertoli cells), human PLU-1 Gene (RBBP Family) encodes 1544-aa 176-kDa nuclear RBP2-Like Protein, containing 3 Cys-rich zinc-binding DNA-binding PHD/LAP domains, a DNA-binding dead ringer domain, 5 putative nuclear localization signals, a putative DNA/chromatin binding motif, and other conserved regions of unknown function. With an additional 137 amino acids, 1681-aa 190-kDa RBBP2H1A appears to be an alternate PLU-1 product that shares 56% overall amino acid sequence identity with RBBP2, important in RB tumor suppressor regulation. (NCI)
C24685	PMAIP1_Gene	Apoptosis_Promoter_Gene|BCL-2_Gene_Family	PMAIP1 Gene|APR|NOXA|PMAIP1|Phorbol-12-Myristate-13-Acetate-Induced Protein 1 Gene	Rapidly induced (2.0-kb mRNA) by PMA, p53-responsive immediate-early-response gene human PMAIP1 Gene encodes 54-aa Immediate-Early-Response Protein APR, containing a BH3 motif, that can induce apoptosis in various cells in a BH3-dependent manner. PMAIP1 shows highest similarity to p53- and X-ray responsive Noxa gene (mouse), encoding 103-aa Noxa protein with 2 BH3 motifs. Noxa exhibits BH3-dependent localization to mitochondria and interacts with antiapoptotic BCL2 family proteins, resulting in activation of caspase-9. PMAIP1/Noxa may mediate p53-dependent apoptosis in cells exposed to noxious stresses.  (NCI)
C24686	PML_Gene	Transcription_Factor_Gene	PML Gene|MYL|PML|Promyelocytic Leukemia Gene|TRIM19	Expressed in a cell-cycle related manner, human PML Gene (TRIM Family) encodes nuclear phosphoprotein Tripartite Motif Protein TRIM19, a transcription factor and tumor suppressor that regulates the p53 response to oncogenic signals, interacts with SIRT1, and contains a TRIM motif: 3 zinc-binding domains, a RING-type zinc finger, a B-box type 1 zinc finger, a B-box type 2 zinc finger, and a coiled-coil region. Extensive alternative splicing results in fourteen variations of the protein's central and C-terminal regions with an invariant N-terminus. Chromosomal translocation t(15;17)(q21;q21) involving PML and RARA is associated with acute promyelocytic leukemia. (NCI)
C24687	POV1_Gene	Transport_Protein_Gene	SLC43A1 Gene|PB39|POV1|POV1 Gene|R00504|SLC43A1|Solute Carrier Family 43, Member 1 Gene	Expressed (2.6-kb transcript) in a variety of tissues (fetal liver and adult pancreas highest), human POV1 Gene encodes 559-aa L-Type Amino Acid Transporter 3, containing a putative secretory signal peptide and a leucine zipper motif. (NCI)
C24688	PPAP2A_Gene	Phosphatase_Family_Gene	PPAP2A Gene|PAP-2a|PPAP2A|Phosphatidic Acid Phosphatase Type 2A Gene	Expressed ubiquitously (1.74-kb transcript), human PPAP2A Gene (PAP Family) encodes 284-aa 32-kDa Phosphatidic Acid Phosphatase Type 2A, a type 2 integral plasma membrane glycoprotein enzyme with extracellular activity predicted to contain 6 transmembrane regions and a conserved N-glycosylation site. PPAP2A exhibits 47% sequence identity with PPAP2B and 54% identity with PPAP2C; the C-terminal 40-aa of PPAP2A, PPAP2B, and PPAP2C show greatest divergence. PPAP2A has an active role in metabolic pathways controlling synthesis of glycerophospholipids and triacylglycerols, in hydrolysis and uptake of lipids from the extracellular space, in dephosphorylation of phosphatidic acid to diacylglycerol, and in receptor-activated signal transduction mediated by phospholipase D. (NCI)
C24689	PPARG_Gene	Nuclear_Receptor_Gene	PPARG Gene|HUMPPARG|NR1C3|PPARG|PPARG1|PPARG2|Peroxisome Proliferative Activated Receptor, Gamma Gene	The protein encoded by this gene is a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Multiple transcript variants that use alternate promoters and splicing have been identified for this gene. At least three of these variants encode the same isoform. (LocusLink)
C24690	PPP1CA_Gene	Protein_Serine-Threonine_Phosphatase_Gene	PPP1CA Gene|PPP1A|PPP1CA	Expressed as a 1.6-kb transcript, human PPP1CA Gene (PP1 Family) encodes cytoplasmic Protein Phosphatase 1 Catalytic Subunit Alpha, one of 3 catalytic subunits (A, B, or C) of PP1 folded by IPP2 and GSK3 and then complexed to various targeting or regulatory subunits. PPP1CA is inhibited by IPP1 and IPP2. Protein phosphorylation is crucial in the regulation of many cellular functions; the level of phosphorylation is controlled by the actions of opposing kinases and phosphatases. PP1 is a major serine/threonine-protein phosphatase essential for cell division, regulation of glycogen metabolism, muscle contractility protein synthesis, regulation of ionic conductances, and long-term synaptic plasticity/memory. PPP1CA may dephosphorylate postsynaptic density-associated Ca++/calmodulin dependent protein kinase II. (NCI)
C24691	PPP2R1B_Gene	Protein_Phosphatase-2A_Subunit_Gene	PPP2R1B Gene|PPP2R1B	Human PPP2R1B Gene (PP2A Subunit A Family) encodes 601-aa 66-kDa Protein Phosphatase 2 Regulatory Subunit A Beta, containing 15 HEAT repeats that form a rod-like structure consisting of alpha helices joined by a hydrophilic loop. PPP2R1B is the constant regulatory scaffolding subunit of PP2 that coordinates assembly of the phosphatase catalytic subunit and various regulatory subunits or cell signaling molecules. A major Ser/Thr phosphatase in cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. PPP2R1B interacts with IPO9. (NCI)
C24692	PRDM1_Gene	Transcription_Corepressor_Gene	PRDM1 Gene|BLIMP1|PR Domain Containing 1, with ZNF Domain Gene|PRDI-BF1|PRDM1	Expression increased on virus induction, human PRDM1 Gene encodes 789-aa 88-kDa PR-Domain Zinc Finger Protein 1, a transcriptional repressor containing a SET domain and 4 C2H2-type zinc fingers. PRDM1 specifically binds to the PRDI (positive regulatory domain I) element of the beta-IFN gene promoter and represses beta-interferon gene expression. PRDM1 also drives maturation of B lymphocytes into Ig secreting cells. (NCI)
C24693	PRDM4_Gene	Transcription_Coregulator_Gene	PRDM4 Gene|PFM1|PR Domain Containing 4 Gene|PRDM4	Expression increased on virus induction, human PRDM1 Gene encodes 789-aa 88-kDa PR-Domain Zinc Finger Protein 1, a transcriptional repressor containing a SET domain and 4 C2H2-type zinc fingers. PRDM1 specifically binds to the PRDI (positive regulatory domain I) element of the beta-IFN gene promoter and represses beta-interferon gene expression. PRDM1 also drives maturation of B lymphocytes into Ig secreting cells. (NCI)
C24694	PRKCA_Gene	Serine-Threonine_Protein_Kinase_Gene	PRKCA Gene|PKCA|PRKCA|Protein Kinase C, Alpha Gene	Human PRKCA Gene (PKC Family) encodes 672-aa 77-kDa Protein Kinase C-alpha, a calcium-activated (likely by the C2 domain), DAG-activated, phospholipid-dependent serine/threonine kinase containing 2 zinc-dependent phorbol-ester/DAG binding domains and a C2 domain that phosphorylates a range of cellular proteins. DAG markedly increases PKC sensitivity to calcium and phospholipids. PKC activation appears to be central in the induction of cellular responses to many ligand-receptor systems and to external stimuli. After GPCR stimulation, and triggered by PKC-dependent serine phosphorylation, RKIP dissociates from RAF1 to associate with and block GRK2 activity. By activating PKC, the receptor signal may be enhanced by removing a RAF1 inhibitor and blocking receptor internalization. A receptor for phorbol ester tumor promoters, PKC may interact with PRKCABP. (NCI)
C24695	PRKG2_Gene	Kinase_Family_Gene	PRKG2 Gene|PRKG2|PRKGR2|Protein Kinase, cGMP-Dependent, Type II Gene	Highly expressed (6-kb and 4.4-kb mRNA) in brain, lung, prostate, thymus, and intestinal mucosa, human PRKG2 Gene (cGMP Ser/Thr Kinase Family) encodes 762-aa 87-kDa Type II cGMP-Dependent Protein Kinase, a physiologic mediator of cGMP containing 2 cyclic nucleotide-binding domains. Type I and II cGMP-dependent protein kinases are encoded by distinct genes. Human cGKII is 96% identical to mouse and rat cGKII. Though not well understood, cGKII function may mediate intestinal secretion of water and electrolytes. NO and diverse hormones, drugs, and toxins increase intracellular cGMP to activate receptors that regulate a variety of functions, including smooth muscle relaxation, neuronal excitability, and epithelial electrolyte transport. (NCI)
C24696	PRKR_Gene	Serine-Threonine_Protein_Kinase_Gene	EIF2AK1 Gene|EIF2AK1|Eukaryotic Translation Initiation Factor 2-Alpha Kinase 2 Gene|PKR|PRKR|PRKR Gene	Induced by interferon, 17-exon human PRKR Gene (GCN2 Family) encodes 551-aa 62-kDa Interferon-Inducible elF2Alpha Kinase, a homodimeric serine/threonine protein kinase containing 2 DRBM domains that is activated by double-stranded RNA in the presence of ATP. Binding to dsRNA induces PRKR dimerization and activation, leading to autophosphorylation in the activation loop, PRKR phosphorylation of EIF2-alpha, and inhibition of protein synthesis initiation. P58(IPK) inhibition by P52(rIPK) upregulates PRKR activity. IFNG mRNA activates PRKR through a conserved 5-prime UTR pseudoknot to control its own translation yield. HCV envelope protein E2 contains a sequence identical to phosphorylation sites of PRKR and EIF2-alpha. E2 inhibits PRKR inhibitory activity on protein synthesis and cell growth, which may contribute to HCV-associated hepatocellular carcinoma. (NCI)
C24697	PTCH2_Gene	Ligand_Binding_Protein_Gene	PTCH2 Gene|PTCH2|Patched Homolog 2 (Drosophila) Gene|SIRP-BETA-1	With 22 coding exons, 15-kb human PTCH2 Gene (Patched Family) encodes 1203-aa transmembrane protein Patched Homolog 2, a possible sonic hedgehog receptor highly similar to PTCH and containing an SSD domain that may have a role formation of embryonic structures and in epidermal development. The Drosophila patched-hedgehog signaling pathway establishes segment polarity and anterior-posterior orientation. The patched pathway is conserved from fly to vertebrates. With 56% identity to Patched-1, mouse Patched-2 diverges in the hydrophilic region between transmembrane domains 6 and 7 and in a region of the intracellular C terminus. (NCI)
C24698	PTHLH_Gene	Growth_Factor_Gene	PTHLH Gene|PTHLH|PTHRP	Human PTHLH Gene encodes Parathyroid Hormone-Like Hormone, an anti-proliferative factor that, through its signaling receptor PTHR1, regulates endochondral bone development, epithelial-mesenchymal interactions, and epidermal cell growth. Because of structural homology with PTH and binding to the PTH/PTHRP receptor, PTHRP can mimic PTH action, but has evolved to regulate local tissue functions, in contrast to systemic parathyroid hormone function. PTHRP functions as a poly-hormone that gives rise to several active peptides, each of which presumably has its own receptor. It appears to also have intracrine nuclear effects in cells that produce it, in addition to autocrine, juxtacrine, paracrine, and possibly endocrine effects. (NCI)
C24699	PTK2_Gene	Non-Receptor_Tyrosine_Kinase_Gene	PTK2 Gene|FADK|FAK|FAK1|PTK2|PTK2 Protein Tyrosine Kinase 2 Gene|pp125FAK	Ubiquitously expressed (most in brain), human PTK2 Gene (FAK Family) encodes Focal Adhesion Kinase 1, a cytoplasmic nonreceptor tyrosine kinase. An endogenous substrate for insulin receptor associated tyrosine kinase and for pp60v-src, tyrosine phosphorylated/activated PTK2 contains a FERM domain and a C-terminal FAT sequence that mediates localization to focal adhesions. Activated by adhesion-induced integrin clustering, neural peptides, ligand-GPCR occupancy, or LDL receptor occupancy, PTK2 is implicated in signaling pathways involved in cell motility, proliferation, and apoptosis. Via interaction of a PTK2 Pro-rich region with an SH3 domain, PTK2 interaction with CRK-associated tyrosine kinase substrate p130-CAS and CASL may be key in integrin-mediated signal transduction and may link SRC and CRK oncoproteins.  (NCI)
C24700	PTK2B_Gene	Non-Receptor_Tyrosine_Kinase_Gene	PTK2B Gene|CADTK|CAKB|FADK2|FAK2|PKB|PTK|PTK2B|PTK2B Protein Tyrosine Kinase 2 Beta Gene|PYK2|RAFTK	This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. PTK2B has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. Four transcript variants encoding two different isoforms have been found for this gene. (LocusLink)
C24701	PTK6_Gene	Non-Receptor_Tyrosine_Kinase_Gene	PTK6 Gene|BRK|PTK6|PTK6 Protein Tyrosine Kinase 6 Gene	The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation. (LocusLink)
C24702	PTK7_Gene	Transmembrane_Protein_Gene	PTK7 Gene|CCK4|PTK7|PTK7 Protein Tyrosine Kinase 7 Gene	Expressed in lung, liver, pancreas, kidney, placenta, melanocytes, thyroid gland, ovary, brain, heart, and skeletal muscle (but not in colon), human PTK7 Gene (INSR family) encodes 1070-aa 118-kDa (precursor) PTK7 Protein Tyrosine Kinase 7, a type I membrane protein containing 7 Ig-like C2-type domains that appears to lack tyrosine kinase catalytic activity and may function as a cell adhesion molecule. PTK7 may be a colon carcinoma tumor progression marker. (NCI)
C24703	PTN_Gene	Growth_Factor_Gene	PTN Gene|HARP|HBGF8|HBNF|NEGF-1|NEGF1|PTN|Pleiotrophin (Heparin Binding Growth Factor 8, Neurite Growth-Promoting Factor 1) Gene	Encodes a secreted growth factor that is mitogenic for endothelial, epithelial, and fibroblast cells but can also induce neurite outgrowth.  It functions as a growth factor during neonatal brain development, for primate trophoblast formation, and during tumor invasion, angiogenesis, and metastasis.
C24704	PTP4A1_Gene	Protein_Tyrosine_Phosphatase_Gene	PTP4A1 Gene|HH72|PRL1|PTP4A1|PTP4A2|PTPCAAX1|Protein Tyrosine Phosphatase Type IVA, Member 1 Gene	Human PTP4A1 Gene (PTP Family) encodes Protein Tyrosine Phosphatase IVA1, a regulatory cell signaling nuclear tyrosine phosphatase primarily associated with the plasma membrane that belongs to a small class of prenylated PTPs, contains a PTP domain and a characteristic C-terminal prenylation motif, and may be an immediate-early gene product in mitogen-stimulated cells. The surface membrane association of PTP4A1 depends on C-terminal prenylation. (NCI)
C24705	PTPN1_Gene	Non-Receptor_Protein_Tyrosine_Phosphatase_Gene	PTPN1 Gene|PTP-1B|PTP1B|PTPN1|Protein Tyrosine Phosphatase, Non-Receptor Type 1 Gene	This gene encodes the founding member of the protein tyrosine phosphatase (PTP) family, which was isolated and identified based on its enzymatic activity and amino acid sequence. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP has been shown to act as a negative regulator of insulin signaling by dephosphorylating the phosphotryosine residues of insulin receptor kinase. This PTP was also reported to dephosphorylate epidermal growth factor receptor kinase, as well as JAK2 and TYK2 kinases, which implicated the role of this PTP in cell growth control, and cell response to interferon stimulation. (LocusLink)
C24706	PTPN12_Gene	Non-Receptor_Protein_Tyrosine_Phosphatase_Gene	PTPN12 Gene|PTP-PEST|PTPG1|PTPN12|Protein Tyrosine Phosphatase, Non-Receptor Type 12 Gene	Human PTPN12 Gene (Non-Receptor PTP Family) encodes 780-aa 88-kDa cytoplasmic Non-Receptor Type 12 Protein Tyrosine Phosphatase, containing a C-terminal PEST motif protein-protein interaction domain. PTPN12 binds to and dephosphorylate the c-ABL product. It also interacts with, and dephosphorylates, cytoskeletal and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and Paxillin, suggesting a role in controlling cell shape and mobility. PTPs typically regulate cell growth, differentiation, and mitotic cycle. Defects in PTPN12 are found in some colon cancers. (NCI)
C24707	PTPN22_Gene	Non-Receptor_Protein_Tyrosine_Phosphatase_Gene	PTPN22 Gene|LYP|Lyp1|Lyp2|PTPN22|Protein Tyrosine Phosphatase, Non-Receptor Type 22 (Lymphoid) Gene	This gene encodes a protein tyrosine phosphatase which is expressed primarily in lymphoid tissues. This enzyme associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms. (LocusLink)
C24708	PTPN6_Gene	Non-Receptor_Protein_Tyrosine_Phosphatase_Gene	PTPN6 Gene|HCP|HCPH|HPTP1C|PTP-1C|PTPN6|Protein Tyrosine Phosphatase, Non-Receptor Type 6 Gene|SH-PTP1|SHP-1|SHP-1L	Expressed predominantly in hematopoietic cells, human PTPN6 Gene (Non-Receptor PTP Family) encodes 3 distinct alternative isoforms of cytoplasmic serine/tyrosine phosphorylated Non-Receptor Type 6 Protein Tyrosine Phosphatase, containing two tandem N-terminal phosphotyrosine binding SH2 domains that mediate interaction with substrates and may modulate phosphatase activity through interaction with other cellular components. A key regulator of hematopoiesis, PTPN6 interacts with, and dephosphorylates, many phosphoproteins involved in hematopoietic cell signaling pathways. PTPN6 binds to PTPNS1, LILRB1, and LILRB2. Protein Tyrosine Phosphatases typically regulate cell growth, differentiation, and mitotic cycle. (NCI)
C24709	PTPN7_Gene	Non-Receptor_Protein_Tyrosine_Phosphatase_Gene	PTPN7 Gene|BPTP-4|HEPTP|LC-PTP|LPTP|PTPN7|PTPNI|Protein Tyrosine Phosphatase, Non-Receptor Type 7 Gene	Preferentially expressed as 2 distinct alternative isoforms in thymic and spleen hematopoietic cells, human early response PTPN7 Gene (Non-Receptor PTP Family) in lymphokine-stimulated cells encodes cytoplasmic Non-Receptor Type 7 Protein Tyrosine Phosphatase, likely involved in regulation of TCR signaling through dephosphorylating MAP kinase pathway molecules; the noncatalytic N-terminus interacts with and suppresses MAP kinase activities. PTPN7 appears to regulate T and B lymphocyte development and signal transduction. Protein Tyrosine Phosphatases typically regulate cellular processes including cell growth, differentiation, and mitotic cycle. (NCI)
C24710	PTPNS1_Gene	Immunoglobulin_Family_Gene	PTPNS1 Gene|BIT|MFR|MYD-1|Macrophage Fusion Receptor Gene|P84|PTPNS1|SHPS1|SIRP|SIRP-ALPHA-1|SIRPalpha|SIRPalpha2	This gene encodes a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. (LocusLink)
C24711	PTPRC_Gene	Protein_Tyrosine_Phosphatase_Gene	PTPRC Gene|B220|CD45|GP180|LCA|LY5|PTPRC|Protein Tyrosine Phosphatase, Receptor Type, C Gene|T200	The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus belongs to receptor type PTP. This gene is specifically expressed in hematopoietic cells. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. (RefSeq)
C24712	PTPRE_Gene	Protein_Tyrosine_Phosphatase_Gene	PTPRE Gene|HPTPE|PTPE|PTPRE|Protein Tyrosine Phosphatase, Receptor Type, E Gene|R-PTP-EPSILON	Human PTPRE Gene (PTP Family) encodes alternative isoforms of Protein Tyrosine Phosphatase Epsilon, containing 2 PTP domains. Alternative transcript 1 encodes 700-aa 81-kDa (precursor) Protein Tyrosine Phosphatase Receptor Type Epsilon Isoform 1, a type I membrane protein receptor-type PTP with a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. Alternative transcript 2 encodes 642-aa Protein Tyrosine Phosphatase Epsilon Isoform 2, a nonreceptor-type cytoplasmic PTP with a distinct hydrophilic N-terminus. Studies of the mouse PTPRE homolog suggest a regulatory role for PTPRE in RAS related signal transduction pathways, cytokine-induced SATA signaling, and activation of voltage-gated K+ channels. (NCI)
C24713	PTPRG_Gene	Protein_Tyrosine_Phosphatase_Gene	PTPRG Gene|HPTPG|PTPG|PTPRG|Protein Tyrosine Phosphatase, Receptor Type, G Gene|R-PTP-GAMMA|RPTPG	Expressed in many tissues (likely developmentally regulated in brain), human PTPRG Gene (PTP Family) encodes Protein Tyrosine Phosphatase Receptor Type G, a likely type I membrane protein receptor-type PTP with an extracellular region containing an eukaryotic-type CAH domain and a fibronectin type III domain, a single transmembrane region, and two tandem intracytoplasmic catalytic PTP domains. PTPs typically regulate cell growth, differentiation, and mitotic cycle. (NCI)
C24714	PTPRJ_Gene	Protein_Tyrosine_Phosphatase_Gene	PTPRJ Gene|CD148|DEP1|HPTPeta|PTPRJ|Protein Tyrosine Phosphatase, Receptor Type, J Gene|R-PTP-ETA|SCC1	Expressed in all hematopoietic lineages, human PTPRJ Gene (PTP Family) encodes 1337-aa 146-kDa (precursor) N- and O-glycosylated type I membrane Protein Tyrosine Phosphatase Receptor Type J, a receptor-type PTP with an extracellular region containing 9 fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic PTP catalytic domain. PTPRJ negatively regulates TCR signaling, possibly by interfering with phosphorylation of PLCG1 and LAT. PTPRJ also dephosphorylates the PDGF beta receptor, may be involved in UV-induced signal transduction, and may contribute to contact inhibition of cell growth. Defects in PTPRJ are found in cancers of colon, lung, and breast. (NCI)
C24715	PTPRR_Gene	Protein_Tyrosine_Phosphatase_Gene	PTPRR Gene|EC-PTP|PCPTP1|PTP-SL|PTPBR7|PTPRQ|PTPRR|Protein Tyrosine Phosphatase, Receptor Type, R Gene	Expressed in brain, kidney, placenta, small intestine, stomach, uterus, or prostate, human PTPRR Gene (PTP Family) encodes alternative alpha, beta, gamma, and delta isoforms of Protein Tyrosine Phosphatase PCPTP1. Type I membrane protein receptor-type PTP isoforms alpha and beta possess an extracellular region, a single transmembrane region, and a single intracellular catalytic domain. Cytoplasmic nonreceptor-type PTP isoforms gamma and delta contain 1 PTP domain and locate in the perinuclear area. PTPRR sequesters inactive MAPKs, such as MAPK1, MAPK3, and MAPK14, in the cytoplasm. MAPKs likely bind to a dephosphorylated kinase interacting motif, phosphorylation of which by Protein Kinase A complex releases MAPKs for activation and nuclear translocation. Mouse Ptprr is expressed predominately in the brain and regulates MAP kinase activity and localization. (NCI)
C24716	PTPRT_Gene	Protein_Tyrosine_Phosphatase_Gene	PTPRT Gene|KIAA0283|PTPRT|Protein Tyrosine Phosphatase, Receptor Type, T Gene|RPTPrho	Expressed in the central nervous system, human PTPRT Gene (PTP Family) encodes type I membrane Protein Tyrosine Phosphatase Receptor Type T, a receptor-type PTP with an extracellular region containing 4 fibronectin type III domains, 1 Ig-like C2-type domain, and 1 MAM domain; a single transmembrane region; and 2 tandem intracellular PTP catalytic domains. PTPRT may be involved in signal transduction and cellular adhesion in the CNS. PTPs typically regulate cell growth, differentiation, and mitotic cycle. The mouse protein structure and expression also suggest a role in signal transduction and cellular adhesion in the central nervous system. (NCI)
C24717	RAD54B_Gene	Helicase_Gene	RAD54B Gene|RAD54 homolog B (S. cerevisiae) Gene|RAD54B	Highly expressed in testis and spleen as two alternative transcripts, human RAD54B Gene (SNF2/SWI2 Family) at 8q21.3-q22 encodes different isoforms of 910-aa 100-kD nucleoplasmic RAD54B Homolog, with significant homology to RAD54 and motifs similar to DNA and RNA helicases. RAD54B binds to double-stranded DNA and displays DNA-associated ATPase activity. RAD54B appears to associate indirectly with RAD51 through its N-terminal domain and may colocalize with RAD54 and BRCA1. Part of a complex involved in meiotic and mitotic homologous DNA recombination repair, RAD54B plays a critical role in targeted integration and recombination in concert with other RAD52 epistasis group members without affecting cell growth, sensitivity to DNA damaging agents, or sister chromatid exchange. (NCI)
C24718	RRAGA_Gene	RAS_Family_Gene	RRAGA Gene|FIP-1|RAGA|RAGA Gene|RRAGA	Human RAGA Gene at 9-21.3 encodes RAS-Related GTP-Binding Protein RAGA, a RAS-related GTP-binding protein lacking GTPase activity that interacts with adenovirus E3 protein and may be part of the TNF Alpha signaling pathway. (NCI)
C24719	RAGE_Gene	Serine-Threonine_Protein_Kinase_Gene	RAGE Gene|MOK|RAGE|RAGE1|Renal Tumor Antigen Gene	Expressed as a 2.2-kb transcript in heart, brain, lung, kidney, pancreas, placenta, liver, and skeletal muscle, human RAGE Gene (MAPK Family) at 14q32 encodes 419-aa cytoplasmic Renal Tumor Antigen, 84% identical overall to the mouse protein (96% identical in the kinase domain) and structurally similar to other MAPKs, including a TEY motif in the activation loop that probably requires autophosphorylation and is required for kinase activity. MOK phosphorylates myelin basic protein. (NCI)
C24720	RAI3_Gene	G_Protein-Coupled_Receptor_Gene	GPRC5A Gene|G Protein-Coupled Receptor, Family C, Group 5, Member A Gene|GPRC5A|RAI3|RAI3 Gene|RAIG1	Rapidly induced by retinoic acid as 2.4- and 6.8-kb transcripts, human RAI3 Gene (GPCR3 Family) at 12p13-p12.3 encodes 357-aa 40-kDa Retinoic Acid Induced 3 protein, containing 7 predicted GPCR-signature transmembrane domains and a potential N-linked glycosylation site. Likely involved in the interaction between retinoid acid and G protein signaling pathways, RAI3 may play a role in embryonic development and epithelial cell differentiation. (NCI)
C24721	RALGDS_Gene	Signaling_Pathway_Gene	RALGDS Gene|RAL Guanine Nucleotide Dissociation Stimulator Gene|RALGDS|RGF|RalGEF	Human RALGDS Gene at 9q34.3 encodes 914-aa 101-kDa RAL Guanine Nucleotide Dissociation Stimulator, a guanine nucleotide exchange factor containing an N-terminal RAS-GEF domain and a noncatalytic C-terminal RAS-associating domain. RALGDS interaction as an effector molecule with RAS-like molecules is specific and dependent on RAS activation by GTP. RALGDS stimulates dissociation of GDP from RAS-related RALA and RALB GTPases, allowing GTP binding and GTPase activation. (NCI)
C24722	RANGAP1_Gene	RAS_Family_Gene	RANGAP1 Gene|Fug1|KIAA1835|RANGAP1	RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. (LocusLink)
C24723	RAP1A_Gene	RAS_Family_Gene	RAP1A Gene|KREV-1|KREV1|RAP1A|SMGP21	Human RAP1A Gene (RAS GTPase Family) at 1p13.3 encodes membrane-bound 184-aa 21-kDa (precursor) RAS-Related Protein RAP1A, activated by guanine nucleotide-exchange factors EPAC and EPAC2, in a cAMP-dependent manner, and by GFR. Interacting with RAS GAPs and RAF in a competitive manner, RAP1A counteracts RAS mitogenic function. (NCI)
C24724	RARB_Gene	Nuclear_Receptor_Gene	RARB Gene|HAP|NR1B2|RARB|RRB2|Retinoic Acid Receptor, Beta Gene	Human RARB Gene (NR1 Family) at 3p24 encodes 4 alternative isoforms of Retinoic Acid Receptor Beta (1-4), composed of three domains: an N-terminal modulating domain, a central DNA-binding domain, and a C-terminal ligand-binding domain. RARB controls embryonic morphogenesis, cell proliferation, and differentiation by directly regulating gene transcription. RARB appears to limit growth of many cell types. (NCI)
C24725	RARRES3_Gene	Regulatory_Gene	RARRES3 Gene|RARRES3|RIG1|Retinoic Acid Receptor Responder (Tazarotene Induced) 3 Gene|TIG3	One of three retinoic acid receptor responders induced by the synthetic retinoid tazarotene. Overexpression of RARRES3 inhibited the growth of many cell lines, suggesting that RARES3 may function as an antiproliferative and antitumor agent. (from OMIM)
C24726	RASD1_Gene	RAS_Family_Gene	RASD1 Gene|AGS1|DEXRAS1|MGC:26290|RASD1	Expressed in a variety of tissues (heart strongest), human RASD1 Gene (RASD GTPase Family) at 17p11.2 encodes 281-aa 32-kDa Activator of G-Protein Signaling 1, a dexamethasone inducted RAS-related protein that may play a role in alterations of cell morphology, growth, and cell-extracellular matrix interactions. RASD1 may form a ternary complex with CAPON and NOS1 and may function as a physiologic nitric oxide (NO) effector. (NCI)
C24727	RBBP9_Gene	Ligand_Binding_Protein_Gene	RBBP9 Gene|BOG|MGC9236|RBBP10|RBBP9|Retinoblastoma Binding Protein 9 Gene	Widely expressed as two alternative transcript variants, human RBBP9 Gene at 20p11.2 encodes 186-aa 21-kDa nuclear/cytoplasmic Retinoblastoma Binding Protein 9, which confers resistance to TGF-Beta 1 growth inhibition through interaction with Rb and subsequent displacement of E2F-1 and may play a role in regulation of cell proliferation and differentiation. (NCI)
C24728	RBL2_Gene	Ligand_Binding_Protein_Gene	RBL2 Gene|P130|RBL2|Rb2|Retinoblastoma-Like 2 (p130) Gene	Restricted to G0 expression, human RBL2 Gene (RB Family) at 16q12.2 encodes 1139-aa 128-kDa nuclear Retinoblastoma-Like 2 protein, which binds to adenovirus E1A protein and to cyclins A and E, associates preferentially with E2F5, inhibits E2F-mediated trans-activation, and may function in cell cycle regulation. Ser-672 phosphorylation in G1 leads to ubiquitin-dependent proteolysis of RBL2. (NCI)
C24729	RBM5_Gene	Ligand_Binding_Protein_Gene	RBM5 Gene|G15|LUCA15|RBM5|RMB5|RNA Binding Motif Protein 5 Gene	Widely expressed, human RBM5 Gene at 3p21.3 encodes in as many as 25 exons 815-aa 92-kDa RNA Binding Motif Protein 5, which contains nuclear localization signals, 2 RRM domains, a G-patch domain, and a RANBP2-type zinc finger, and specifically binds to RNA. (NCI)
C24730	RBM6_Gene	Ligand_Binding_Protein_Gene	RBM6 Gene|3G2|DEF3|NY-LU-12|RBM6|RNA Binding Motif Protein 6 Gene|g16	Widely expressed, human RBM6 Gene at 3p21.3 encodes 1,123-aa RNA Binding Motif Protein 6, which contains 20 inexact 6-aa N-terminal repeats, 2 RNA-binding domains, 2 zinc finger motifs, nuclear localization signals, and specifically binds RNA. (NCI)
C24731	RBX1_Gene	Ligand_Binding_Protein_Gene	RBX1 Gene|BA554C12.1|MGC13357|MGC1481|RBX1|ROC1|Ring-Box 1 Gene	Widely expressed human RBX1 Gene (RING-Box Family) at 22q13.2 encodes conserved cytoplasmic and nuclear 108-aa 12.3-kDa RING Box Protein 1, containing a RING-type zinc finger, that mediates protein turnover of cell cycle, signal transduction, and transcription proteins by ubiquitination and proteasomal degradation. A component of various SCF, SCF-like, and CBC multisubunit E3 ubiquitin ligase complexes, RBX1 may recruit E2 enzymes to the complex through its RING-type zinc finger and heterodimerizes with cullins in the third step of ubiquitin conjugation reactions to catalyze ubiquitin polymerization. RBX1 promotes neddylation of CUL1 and probably CUL2. It also probably interacts with CDC34 and may stimulate CDC34 autoubiquitination. (NCI)
C24732	RCN2_Gene	Ligand_Binding_Protein_Gene	RCN2 Gene|E6BP|ERC-55|ERC55|RCN2|Reticulocalbin 2, EF-Hand Calcium Binding Domain Gene	Human RCN2 Gene (CREC Family) at 15q23 encodes ubiquitous 317-aa 55-kD calcium-binding Reticulocalbin 2, containing 6 conserved helix-loop-helix EF-hand calcium-binding domains and a C-terminal HDEL sequence required for ER retention. RCN2 appears to interact with human papillomavirus transforming protein E6 and with the vitamin D receptor. (NCI)
C24733	RFP_Gene	Ligand_Binding_Protein_Gene	RFP Gene|RET Finger Protein Gene|RFP	Alternatively spliced transcript variants, alpha and beta, of human RFP Gene (TRIM Family) at 6p22 encode 513-aa 58.5-kDa RET Finger Protein, containing a TRIM motif: 3 zinc-binding domains, a RING, a type 1 and type 2 B-box, and a coiled-coil region. Located in the nuclear matrix, RFP interacts with enhancer of polycomb protein, represses gene transcription, and is thought to be involved in male germ cell differentiation. Gene rearrangements with RET produce RET transforming protein, containing the RFP N-terminus with the RET protein tyrosine kinase. (NCI)
C24734	RFP2_Gene	Gene_with_Unknown_or_Unclassified_Function	RFP2 Gene|LEU5|RET Finger Protein 2 Gene|RFP2|TRIM13	Two alternative transcript variants of human RFP2 Gene (TRIM Family) at 13q14 encode 407-aa 47-kDa RET Finger Protein 2, of unknown function, localized to cytoplasmic bodies near the nucleus, and containing a TRIM motif: 3 zinc-binding domains, a RING, a type 1 and a type 2 B-box, and a coiled-coil region. RFP2 may act as a tumor suppressor and may be involved in 13q14 deletion B-CLL. (NCI)
C24735	RGS1_Gene	RGS_Family_Gene	RGS1 Gene|1R20|BL34|IER1|IR20|RGS1|Regulator of G-Protein Signalling 1 Gene	Induced in response to several activation signals, 4-kb 4-exon B-cell specific immediate early human RGS1 Gene (RGS Family) at 1q31 encodes 196-aa 22.5-kDa Regulator of G-Protein Signaling 1, containing 1 RGS domain and likely involved in regulation of B-cell activation and proliferation. Potentially regulated by protein kinase(s), RGS1 inhibits signal transduction by increasing GTPase activity of G protein alpha subunits, driving them into the inactive GDP-bound form.  (NCI)
C24736	RGS19_Gene	RGS_Family_Gene	RGS19 Gene|GAIP|RGS19|RGSGAIP|Regulator of G-Protein Signalling 19 Gene	Expressed most in lung, placenta, liver, and heart, human RGS19 Gene (RGS Family) at 20q13.3 encodes membrane-bound fatty acylated 217-aa 25-kDa Regulator of G-protein Signaling 19, a guanosine triphosphatase-activating protein containing 1 RGS domain that specifically interacts with G protein GAI3 and down-regulates G Alpha i/G Alpha q-linked signaling. Heavily palmitoylated in the Cys string motif and mainly phosphorylated on Ser residues, RGS19 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, driving them into the inactive GDP-bound form. RGS19 binds to G-Alpha subfamily 1 members and interacts with GIPC PDZ domain. (NCI)
C24737	RGS2_Gene	RGS_Family_Gene	RGS2 Gene|G0S8|RGS2|Regulator of G-Protein Signalling 2, 24kDa Gene	Human RGS2 Gene (RGS Family, 5 exons and a 5-prime CpG island) at 1q31 encodes 211-aa 24-kDa Regulator of G-Protein Signaling 2, a basic HLH phosphoprotein containing 1 RGS domain with similarity to lymphocyte-specific 1R20 and phosphorylated by PKC. RGS2 inhibits signal transduction by increasing GTPase activity of G protein alpha subunits, driving them into the inactive GDP-bound form. RGS2 also reduces cAMP production by inhibiting odorant-stimulated Alpha-OLF linked adenylyl cyclase type III activity in olfactory neurons. (NCI)
C24738	RGS3_Gene	RGS_Family_Gene	RGS3 Gene|C2PA|FLJ20370|PDZ-RGS3|RGP3|RGS3|Regulator of G-Protein Signalling 3 Gene	Multiple alternative transcript variants of human RGS3 Gene (RGS Family) at 9q32 encode 519-aa 56.6-kDa cytosolic Regulator of G-Protein Signaling 3, containing 1 RGS domain and likely phosphorylated by cyclic GMP-dependent protein kinase. RGS3 inhibits G-protein mediated signal transduction by increasing G protein alpha subunit GTPase activity, promoting its conversion to the inactive GDP-bound form. G-protein activation leads to translocation of RGS3 to the plasma membrane. (NCI)
C24739	RHOK_Gene	Serine-Threonine_Protein_Kinase_Gene	GRK1 Gene|G Protein-Coupled Receptor Kinase 1 Gene|GRK1|RHOK|RK|Rhok Gene	Human RHOK Gene (GPRK Family) at 13q34 encodes 563-aa 64-kDa membrane-bound Rhodopsin Kinase, containing 1 RGS domain, which regulates GPCR rhodopsin desensitization and initiates rhodopsin deactivation by phosphorylation following light stimulation. (NCI)
C24740	RIL_Gene	Gene_with_Unknown_or_Unclassified_Function	PDLIM4 Gene|PDLIM4|PDZ and LIM Domain 4 Gene|RIL	Alternative transcript isoforms of 7-exon 14.5-kb human RIL Gene at 5q31.1 encode 330-aa 35-kDa LIM Domain Protein, containing a LIM zinc-binding domain and a PDZ/DHR domain. The last 2 exons encode the LIM domain. (NCI)
C24741	RIPK2_Gene	Serine-Threonine_Protein_Kinase_Gene	RIPK2 Gene|CARD3|CARDIAK|RICK|RIP2|RIPK2|Receptor-Interacting Serine-Threonine Kinase 2 Gene	The gene product of the gene is a Serine/threonine kinase, and interacts with CD40 or the tumor necrosis factor receptor.  It has a C-terminal domain for caspase recruitment and activation. (LocusLink)
C24742	RIPK3_Gene	Serine-Threonine_Protein_Kinase_Gene	RIPK3 Gene|RIP3|RIPK3|Receptor-Interacting Serine-Threonine Kinase 3 Gene	Expressed in heart, brain, placenta, skeletal muscle, kidney, pancreas, spleen, lung, peripheral blood leukocytes, prostate, testis, and colon, human RIPK3 Gene (Ser/Thr Kinase Family) at 14q11.2 encodes autophosphorylated (Lys50) cytoplasmic 518-aa 57-kDa Receptor-Interacting Serine/Threonine Kinase 3, containing a distinct C terminus that interacts with RIPK1and an N-terminal kinase domain similar to RIPK1 and RIPK2. RIPK3 also colocalizes in the mitochondrion with RIPK1. RIPK3 is recruited to the TNFR1 complex in a RIPK1-dependent manner and interacts with TRAF2. The RIPK3 C terminus is required to induce apoptosis through the activation of some or all caspases and also appears to activate NFKB. RIPK3 can stimulate NFKB nuclear translocation. (NCI)
C24743	RNF11_Gene	Gene_with_Unknown_or_Unclassified_Function	RNF11 Gene|CGI-123|DKFZP564O033|RNF11|Ring Finger Protein 11 Gene|SID1669|Sid1669p	Human RNF11 Gene at 1pter-p22.1 encodes 154-aa 17-kDa Ring Finger Protein 11, containing a RING-H2 zinc finger motif important for protein-protein interactions. RNF11 may interact with NEDD4. RNF11 expression is induced by mutant RET proteins (MEN2A/MEN2B).  (NCI)
C24744	ROCK1_Gene	Serine-Threonine_Protein_Kinase_Gene	ROCK1 Gene|P160ROCK|ROCK1|Rho-Associated, Coiled-Coil Containing Protein Kinase 1 Gene	Human ROCK1 Gene at 18q11.1 encodes Rho-Associated Coiled-Coil Containing Protein Kinase 1, a Ser/Thr kinase activated when bound to GTP-bound Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between inactive GDP-bound and active GTP-bound forms. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. As a downstream effector of Rho, ROCK phosphorylates and activates LIM kinase, which phosphorylates cofilin and inhibits its actin-depolymerizing activity. (NCI)
C24745	ROR1_Gene	Receptor_Tyrosine_Kinase_Gene	ROR1 Gene|NTRKR1|Receptor Tyrosine Kinase-Like Orphan Receptor 1 Gene|dJ537F10.1	Expressed in heart, lung, kidney, and CNS, human ROR1 Gene (ROR/Tyr Kinase Family) at 1p32-p31 encodes 2 alternative isoforms of 937-aa 10-kDa (precursor) type I membrane protein Receptor Tyrosine Kinase-Like Orphan Receptor 1, a receptor protein tyrosine kinase containing a FZ domain, 1 Ig-like C2-type domain, and 1 kringle domain whose cellular function has not been determined. ROR1 may interact with another receptor protein tyrosine kinase and be involved in skeletal and cardiac development. (NCI)
C24746	ROR2_Gene	Receptor_Tyrosine_Kinase_Gene	ROR2 Gene|BDB|BDB1|NTRKR2|Receptor Tyrosine Kinase-Like Orphan Receptor 2 Gene	Expressed during early embryonic development and only at low levels in adult tissues, human ROR2 Gene (ROR/Tyr Kinase Family) at 9q22 encodes 943-aa 105-kDa (precursor) Receptor Tyrosine Kinase-Like Orphan Receptor 2, a type I transmembrane receptor protein tyrosine kinase containing a FZ domain, an Ig-like C2-type domain, and a kringle domain that may be involved in early formation of chondrocytes and cartilage development. (NCI)
C24747	RORA_Gene	Orphan_Nuclear_Receptor_Gene	RORA Gene|NR1F1|RAR-Related Orphan Receptor A Gene|ROR1|ROR2|ROR3|RORA|RZRA	Human RORA Gene (NR1 Family) at 15q21-q22 encodes 4 alternative isoforms of monomeric or homodimeric 556-aa 63-kDa nuclear RAR-Related Orphan Receptor A, an orphan hormone receptor that binds to genomic DNA regulatory elements of hormone-responsive genes containing a single core motif half-site preceded by a short A-T-rich sequence. RORA interacts with nucleoside diphosphate kinase NM23-2, involved in organogenesis and differentiation, as well as with metastasis suppressor NM23-1 gene product. (NCI)
C24748	RPL10_Gene	Ribosome_Subunit_Gene	RPL10 Gene|DXS648|DXS648E|FLJ23544|NOV|QM|RPL10|Ribosomal Protein L10 Gene	Down-regulated during adipocyte, kidney, and heart differentiation, human RPL10 Gene (L10E Family) at Xq28 encodes 213-aa 24-kDa cytoplasmic Ribosomal Protein L10, a component of the ribosomal 60S subunit. Ribosomes catalyze protein synthesis and consist of 40S and 60S subunits composed of 4 rRNAs and approximately 80 structurally distinct proteins. RPL10 may bind to and repress c-Jun transcriptional activation. Typical for ribosomal protein genes, there are multiple processed RPL10 pseudogenes throughout the genome. (NCI)
C24749	RPL7A_Gene	Ribosome_Subunit_Gene	RPL7A Gene|RPL7A|Ribosomal Protein L7A Gene|SURF3|TRUP	Located in the tightly linked Surfeit Gene cluster and co-transcribed with small nucleolar RNA genes located in its introns, human RPL7A Gene (L7AE Family) at 9q34 encodes 265-aa 30-kDa Ribosomal Protein L7a, a component of the 60S ribosomal subunit. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. RPL7A can inhibit a subclass of transactivating nuclear hormone receptors, including THR, by preventing DNA binding. Gene rearrangements with TRK form TRK-2H, which encodes an oncoprotein of the RPL7A N terminus fused to the TRK tyrosine kinase domain. There are multiple processed RPL7A pseudogenes throughout the genome. (NCI)
C24750	RPS19_Gene	Ribosome_Subunit_Gene	RPS19 Gene|DBA|RPS19|Ribosomal Protein S19 Gene	The 6-exon 11-kb human RPS19 Gene (S19E Family) at 19q13.2 encodes 144-aa 16-kDa cytoplasmic Ribosomal Protein S19, a component of the 40S ribosomal subunit. S19 lacks cysteine residues and has a possible function in erythropoietic differentiation and proliferation. The first exon is untranslated and the ATG start codon is located at the beginning of exon 2. No TATA or CAAT boxes can be identified. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. There are multiple processed RPS19 pseudogenes dispersed throughout the genome. (NCI)
C24751	RPS27_Gene	Ribosome_Subunit_Gene	RPS27 Gene|MPS-1|MPS1|RPS27|Ribosomal Protein S27 (Metallopanstimulin 1) Gene	Expressed in actively proliferating cells, human RPS27 Gene (S27E Family) at 1q21 encodes 83-aa 9-kDa Ribosomal Protein S27, located in the cytoplasm as a component of the 40S ribosomal subunit but also detected in the nucleus. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. S27 appears to be located near ribosomal protein S18 and to be covalently linked to translation initiation factor eIF3. S27 contains a C4-type zinc finger domain and is able to bind to nucleic acid. Multiple processed RPS27 pseudogenes are dispersed throughout the genome. (NCI)
C24752	RPS3_Gene	Ribosome_Subunit_Gene	RPS3 Gene|RPS3|Ribosomal Protein S3 Gene	Human RPS3 Gene (S3P Family) at 11q13.3-q13.5 encodes cytoplasmic and nuclear 243-aa 27-kDa Ribosomal Protein S3, containing a KH type-2 domain and a component of the 40S ribosomal subunit as part of the translation initiation domain. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. RPS3 also appears to be an endonuclease involved in UV-induced DNA repair. RPS3 is co-transcribed with small nucleolar RNA genes located in its first and fifth introns and multiple processed RPS3 pseudogenes are dispersed throughout the genome. (NCI)
C24753	RPS6KA5_Gene	Serine-Threonine_Protein_Kinase_Gene|Signaling_Pathway_Gene	RPS6KA5 Gene|MSK1|MSPK1|RLPK|RPS6KA5|Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 Gene	Widely expressed in heart, brain, placenta, lung, kidney, and liver, human RPS6KA5 Gene (S6 Ser/Thr Kinase Family) at 14q31-q32.1 encodes predominantly nuclear 802-aa 90-kDa Ribosomal Protein S6 Kinase Alpha 5, a Ser/Thr kinase that associates with, phosphorylates, and controls NF-Kappa-B p65 subunit (RELA) transcriptional activity in response to TNF. RPS6KA5 activity requires the presence of both kinase domains. Likely activated by ERK1/2 and p38 Ser/Thr phosphorylations, RPS6KA5 transiently dissociates from complexes with ERK1/2 following mitogenic stimulation and may mediate growth factor and stress induced activation of transcription factor CREB. RPS6KA5 also associates with MAPK14/p38alpha. (NCI)
C24754	RPS6KB2_Gene	Kinase_Family_Gene	RPS6KB2 Gene|P70-BETA|RPS6KB2|Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 Gene|p70S6Kb	Human RPS6KB2 Gene (S6 Ser/Thr Kinase Family) at 11q13.1 encodes 482-aa 53-kDa Ribosomal Protein S6 Kinase Beta 2. RPS6KB2 specifically phosphorylates 40S ribosomal protein S6, the major eukaryotic ribosome substrate of many kinases. S6 phosphorylation is stimulated by growth factors and mitogens; dephosphorylation occurs at growth arrest. S6 may control cell growth and proliferation through the selective translation of specific of mRNA classes. (NCI)
C24755	RRAS2_Gene	RAS_Family_Gene	RRAS2 Gene|RRAS2|TC21	Human RRAS2 Gene (RAS GTPase Family) at 11p15.2 encodes ubiquitous 204-aa 23-kDa RAS-Related Protein R-RAS2, a plasma membrane-associated GTP-binding GTPase that may transduce growth inhibitory signals by exerting an antagonistic effect on a RAS effector. RRAS2 may be posttranslationally modified by palmitoylation and polyisoprenylation. Attachment to the inner surface of plasma membrane may require acylation of a C-terminal cysteine. RRAS2 defects can cause ovarian tumors. (NCI)
C24756	RRP22_Gene	RAS_Family_Gene	RRP22 Gene|RRP22	Expressed as a 1.4-kb mRNA in brain, human RRP22 Gene (Small GTPase Family) at 22q12.2 encodes 203-aa 23-kDa RAS-Like Protein RRP22. (NCI)
C24757	RSU1_Gene	Gene_with_Unknown_or_Unclassified_Function	RSU1 Gene|RSP-1|RSU1|Ras Suppressor Protein 1 Gene	Expressed as multiple alternative transcript variants, human RSU1 Gene at 10p13 encodes RAS Suppressor Protein 1, likely involved in the RAS signal transduction pathway, growth inhibition, and NGF-induced differentiation. RSU1 contains 7 LRR repeats and may antagonize RAS. (NCI)
C24758	RYK_Gene	Kinase_Family_Gene	RYK Gene|D3S3195|RYK|RYK Receptor-Like Tyrosine Kinase Gene|RYK1	Widely expressed, human RYK Gene (TYR Kinase Family) at 3q22 encodes 604-aa 68-kDa (precursor) RYK Receptor-Like Tyrosine Kinase, a potential growth factor receptor protein tyrosine kinase containing a WIF domain that differs from other family members at a number of conserved residues in the activation and nucleotide binding domains. RYK does not appear to be regulated by phosphorylation in the activation segment and mediation of biological activity may occur by recruitment of a signaling-competent auxiliary protein. (NCI)
C24759	S100A11_Gene	S100_Family_Gene	S100A11 Gene|Calgizzarin Gene|MLN70|S100 Calcium Binding Protein A11 (Calgizzarin) Gene|S100A11|S100C	Human S100A11 Gene (S100 Family) at 1q21 encodes 105-aa 12-kDa homodimeric S100 Calcium Binding Protein A11, containing 2 EF-hand calcium-binding motifs, that may function in motility, invasion, and tubulin polymerization. (NCI)
C24760	S100A12_Gene	S100_Family_Gene	S100A12 Gene|CAAF1|CGRP|ENRAGE|MRP6|S100 Calcium Binding Protein A12 (Calgranulin C) Gene|S100A12|p6	Expressed in monocytes and lymphocytes, human S100A12 Gene (S100 Family) at 1q21 encodes 91-aa 10-kDa (precursor) homodimeric S100 Calcium Binding Protein A12, containing 2 EF-hand calcium-binding motifs and involved in regulatory effects on cytoskeletal components and in calcium-dependent signal transduction pathways. (NCI)
C24761	S100A8_Gene	S100_Family_Gene	S100A8 Gene|60B8AG|CAGA|CFAG|CGLA|CP-10|L1Ag|MA387|MIF|MRP8|NIF|P8|S100 Calcium Binding Protein A8 (Calgranulin A) Gene|S100A8	Constitutively expressed in epithelial cells and in macrophages during chronic inflammation, human S100A8 Gene (S100 Family) encodes 93-aa 11-kDa S100 Calcium Binding Protein A8, a homodimer containing 2 EF-hand calcium-binding motifs that may interact with intermediate filament components and function in casein kinase inhibition. (NCI)
C24762	S100A9_Gene	S100_Family_Gene	S100A9 Gene|60B8AG|CAGB|CFAG|CGCB|L1AG|LIAG|MAC387|MIF|MRP14|NIF|P14|S100 Calcium Binding Protein A9 (Calgranulin B) Gene|S100A9	Constitutively expressed in epithelial cells and by macrophages in inflamed tissues, human S100A9 Gene (S100 Family) at 1q21 encodes 114-aa 13-kDa S100 Calcium Binding Protein A9, containing 2 EF-hand calcium-binding motifs, which may inhibit protein kinases and interact with intermediate filament components. (NCI)
C24763	S100P_Gene	S100_Family_Gene	S100P Gene|S100 Calcium Binding Protein P Gene|S100P	Human S100P Gene (S100 Family) at 4p16 encodes 95-aa 10-kDa S100 Calcium Binding Protein P, containing 2 EF-hand calcium-binding motifs, which binds Ca2+, Zn2+, and Mg2+ and interacts with S100Z. (NCI)
C24764	SCAP2_Gene	Adaptor_Signaling_Protein_Gene	SCAP2 Gene|RA70|SAPS|SCAP2|SKAP-HOM|SKAP55R|SRC Family Associated Phosphoprotein 2 Gene	Expressed in lung, skeletal muscle, kidney, peripheral leukocytes, spleen, brain, placenta, heart, prostate, testis, ovary, and colon, human SCAP2 Gene (SRC Kinase Family) at 7p21-p15 encodes 359-aa SRC Family Associated Phosphoprotein 2, an adaptor protein implicated in myeloid differentiation and growth arrest and thought to play a role in SRC signal transduction pathways of tyrosine and nontyrosine kinase receptors. Like SKAP55, SKAP55R contains a PH domain, multiple tyrosine phosphorylation sites, and an SH3 domain. Unlike SKAP55, SKAP55R has an N-terminal coiled-coil domain. SKAP55R and SKAP55 are phosphorylated by FYN, but not LCK or ZAP70. Unlike SKAP55, SKAP55R is not constitutively phosphorylated in T cells. FYB in T cells binds SKAP55 and SKAP55R through their SH3 domains. (NCI)
C24765	SCTR_Gene	G_Protein-Coupled_Receptor_Gene	SCTR Gene|SCTR|SR|Secretin Receptor Gene	Human SCTR Gene (GPCR2 Family) at 2q14.1 encodes 440-aa 50-kDa (precursor) 7 transmembrane integral membrane protein Secretin Receptor, which binds secretin and, mediated by G proteins that activate adenylyl cyclase, regulates pancreatic bicarbonate, enzyme, and potassium ion secretion. (NCI)
C24766	CCL1_Gene	CC_Cytokine_Gene	CCL1 Gene|CCL1|Chemokine (C-C Motif) Ligand 1 Gene|I-309|P500|SCYA1|SISe|TCA3	Induced by PMA in activated T cells, human CCL1 Gene (Intercrine Beta Family) at 17q11.2 encodes secreted immunoregulatory monomeric 96-aa 11-kD (precursor) Small Inducible Cytokine A1 (related to CXC cytokines), which binds to CCR8 receptor and has chemotactic activity for monocytes in inflammatory processes.  (NCI)
C24767	CCL11_Gene	CC_Cytokine_Gene	CCL11 Gene|CCL11|Chemokine (C-C motif) Ligand 11 Gene|MGC22554|SCYA11	This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil specific chemokine assumed to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. (LocusLink)
C24768	CCL13_Gene	CC_Cytokine_Gene	CCL13 Gene|CCL13|CKb10|Chemokine (C-C Motif) Ligand 13 Gene|MCP-4|MGC17134|NCC-1|NCC1|SCYA13|SCYL1	Induced by IL-1 and TNF-alpha and widely expressed, human CCL13 Gene (Intercrine Beta Family) encodes 98-aa 11-kD (precursor) Small Inducible Cytokine A13, a secreted chemotactic factor for monocytes, lymphocytes, basophils, and eosinophils that signals through CCR2B and CCR3 receptors and is involved in immunoregulatory and inflammatory processes. The protein can bind heparin and isoforms MCP-4, (LA)MCP-4, and (FNPQGLA)MCP-4 exist. CCL13 may be involved in atherosclerosis. (NCI)
C24769	CCL14_Gene	CC_Cytokine_Gene	CCL14 Gene|CC-1|CC-3|CCL14|CKb1|Chemokine (C-C Motif) Ligand 14 Gene|HCC-1|HCC-3|MCIF|NCC-2|NCC2|SCYA14|SCYL2|SY14	Constitutively expressed in several tissues, human CCL14 Gene (Intercrine Beta Family) at 17q11.2 encodes secreted 93-aa 11-kD (precursor) Small Inducible Cytokine A14, which acts via MIP-1 alpha receptors to induce intracellular calcium changes and enzyme release in monocytes and to enhance CD34 myeloid progenitor cell proliferation. CCL14 expresses monocistronic and bicistronic transcripts (includes upstream CCL15 gene). The bicistronic transcripts undergo alternative splicing. (NCI)
C24770	CCL15_Gene	CC_Cytokine_Gene	CCL15 Gene|CCL15|Chemokine (C-C Motif) Ligand 15 Gene|HCC-2|HMRP-2B|LKN1|Lkn-1|MIP-1d|MIP-5|NCC-3|NCC3|SCYA15|SCYL3|SY15	Widely expressed human CCL15 Gene (Intercrine Beta Family), at 17q11.2 encodes secreted 113-aa 12-kDa (precursor) Small Inducible Cytokine A15, a chemotactic factor for T cells and monocytes that acts mainly via CCR1, induces intracellular calcium changes in monocytes, and induces N-acetyl-beta-D-glucosaminidase release in monocytes. CCL15 also binds to CCR3. Monocistronic and bicistronic CCL15 transcripts encode the same protein. The alternatively spliced bicistronic transcripts include the downstream CCL14 gene. (NCI)
C24771	CCL17_Gene	CC_Cytokine_Gene	CCL17 Gene|A-152E5.3|ABCD-2|CCL17|Chemokine (C-C Motif) Ligand 17 Gene|SCYA17|TARC	Expressed in thymus, lung, colon, and small intestine and induced by PHA in mononuclear cells and by cytokines in monocytes, human CCL17 Gene (Intercrine Beta Family) at 16q13 encodes secreted 94-aa 10-kD (precursor) Small Inducible Cytokine A17, an immunoregulatory chemotactic factor for T lymphocytes that binds to CCR4 and CCR8 receptors and is important in inflammatory processes, in thymic T cell development, and in trafficking and activation of mature T cells. (NCI)
C24772	CCL18_Gene	CC_Cytokine_Gene	CCL18 Gene|AMAC-1|AMAC1|CCL18|CKb7|Chemokine (C-C Motif) Ligand 18 Gene|DC-CK1|DCCK1|MIP-4|PARC|SCYA18	Induced by glucocorticoids, PMA, IL-4, IL-13, and IL-10 and expressed in lung, lymph nodes, placenta, bone marrow, dendritic cells, and macrophages, human CCL18 Gene (Intercrine Beta Family) at 17q11.2 encodes secreted 89-aa 10-kDa (precursor) Small Inducible Cytokine A18, an immunoregulatory chemotactic cytokine for naive T cells, CD4+ and CD8+ T cells, and nonactivated lymphocytes involved in inflammatory processes s well as humoral and cell-mediated immunity. CCL18 may be involved in B cell migration into lymph node follicles. (NCI)
C24773	CCL19_Gene	CC_Cytokine_Gene	CCL19 Gene|CCL19|CKb11|Chemokine (C-C Motif) Ligand 19 Gene|ELC|MGC34433|MIP-3b|MIP3B|SCYA19	Expressed in lymph nodes, thymus, appendix, colon, trachea, spleen, small intestine, lung, kidney, and stomach, human CCL19 Gene (Intercrine Beta Family) at 9p13 encodes secreted immunoregulatory 98-aa 11-kD (precursor) Small Inducible Cytokine A19, involved in inflammatory and immunological responses, that binds to CCR7 receptor and plays a role in thymic T cell trafficking and in T and B cell migration. (NCI)
C24774	CCL20_Gene	CC_Cytokine_Gene	CCL20 Gene|CCL20|CKb4|Chemokine (C-C Motif) Ligand 20 Gene|LARC|MIP-3a|MIP3A|SCYA20|ST38	Repressed by IL-10 and induced by LPS, PMA, TNF, and INF Gamma in liver, lymph nodes, appendix, PBL, thymus, prostate, testis, small intestine, colon, and fetal lung, human CCL20 Gene (Intercrine Beta Family) at 2q33-q37 encodes 2 alternative isoforms of secreted Small Inducible Cytokine A20, a chemotactic factor for lymphocytes, neutrophils, and dendritic cells that binds CCR6 and may inhibit proliferation of myeloid progenitors. (NCI)
C24775	CCL21_Gene	CC_Cytokine_Gene	CCL21 Gene|CCL21|CKb9|Chemokine (C-C Motif) Ligand 21 Gene|MGC34555|SCYA21|SLC|TCA4	This gene encodes small Inducible cytokine A2, a member of cytokine family. It plays a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 (CCR7) that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). (from LocusLink)
C24776	CCL22_Gene	CC_Cytokine_Gene	CCL22 Gene|A-152E5.1|ABCD-1|CCL22|Chemokine (C-C Motif) Ligand 22 Gene|DC/B-CK|MDC|MGC34554|SCYA22|STCP-1	Expressed in macrophage, monocyte-derived dendritic cells, thymus, lymph node, appendix, activated monocytes, resting and activated macrophages, lung, small intestine, and spleen, human CCL22 Gene (Intercrine Beta Family) at 16q13 encodes secreted immunoregulatory 93-aa 11-kD (precursor) Small Inducible Cytokine A22, a chemotactic factor for monocytes, dendritic cells, natural killer cells, and activated T lymphocytes that binds to receptor CCR4 and may play a role in activated/effector T lymphocyte trafficking to inflammatory sites. (NCI)
C24777	CCL23_Gene	CC_Cytokine_Gene	CCL23 Gene|CCL23|CK-BETA-8|CKb8|Chemokine (C-C Motif) Ligand 23 Gene|Ckb-8|Ckb-8-1|MIP-3|MIP3|MPIF-1|SCYA23	Expressed in lung, liver, skeletal muscle, bone marrow, placenta, pancreas, and fetal liver, human CCL23 Gene (Intercrine Beta Family) at 17q12 encodes secreted immunoregulatory Small Inducible Cytokine A23 Isoform Ckbeta8, a potent CCR1 receptor agonist and suppressor of progenitor cell colony formation with chemotactic activity for resting T lymphocytes, monocytes, and neutrophils in inflammatory processes.  (NCI)
C24778	CCL24_Gene	CC_Cytokine_Gene	CCL24 Gene|CCL24|Chemokine (C-C Motif) Ligand 24 Gene|Ckb-6|MPIF-2|MPIF2|SCYA24	Expressed by activated monocytes and activated T lymphocytes, human CCL24 Gene (Intercrine Beta Family) at 7q11.23 encodes N-glycosylated secreted immunoregulatory Small Inducible Cytokine A24 with chemotactic activity for resting T lymphocytes, neutrophils, and eosinophils in inflammatory processes that binds to CCR3 and exhibits strong suppression of hematopoietic progenitor colony formation. (NCI)
C24779	CCL25_Gene	CC_Cytokine_Gene	CCL25 Gene|CCL25|Chemokine (C-C Motif) Ligand 25 Gene|Ckb15|SCYA25|TECK	Expressed by dendritic cells in thymus and small intestine, CCL25 Gene (Intercrine Beta Family) at 19p13.2 encodes secreted immunoregulatory 150-aa 17-kD (precursor) Small Inducible Cytokine A25, a CCR9 receptor agonist and chemotactic for thymocytes, activated macrophages, THP-1 cells, and dendritics cells in inflammatory processes. Two alternatively spliced variants encode antagonist isoforms. (NCI)
C24780	CCL26_Gene	CC_Cytokine_Gene	CCL26 Gene|CCL26|Chemokine (C-C Motif) Ligand 26 Gene|IMAC|MIP-4a|MIP-4alpha|SCYA26|TSC-1	Ubiquitously expressed human CCL26 Gene (Intercrine Beta Family) at 7q11.23 encodes secreted monomeric immunoregulatory 94-aa 11-kD (precursor) Small Inducible Cytokine A26, an activator of receptor CCR3 and chemotactic for eosinophils and basophils in inflammatory processes. CCL26 may contribute to eosinophil accumulation in atopic diseases. (NCI)
C24781	CCL27_Gene	CC_Cytokine_Gene	CCL27 Gene|ALP|CCL27|CTACK|CTAK|Chemokine (C-C Motif) Ligand 27 Gene|ESKINE|ILC|PESKY|SCYA27	Expressed in testis, thymus, placenta, ovary, and skin, human CCL27 Gene (Intercrine Beta Family) at 9p13 encodes immunoregulatory 112-aa 12.6-kD (precursor) Small Inducible Cytokine A27, a chemotactic factor that binds to CCR10 and mediates homing of memory T lymphocytes to cutaneous sites in inflammatory processes. (NCI)
C24782	CCL3_Gene	CC_Cytokine_Gene	CCL3 Gene|CCL3|Chemokine (C-C Motif) Ligand 3 Gene|G0S19-1|LD78ALPHA|MIP-1-alpha|MIP1A|SCYA3	Macrophage Inflammatory Protein-1 is a monokine involved in the acute inflammatory recruitment and activation of polymorphonuclear leukocytes.  There are two protein components of MIP1, alpha and beta. MIP-1 alpha has been identified as an early G0/G1 switch gene in blood mononuclear cells.  RANTES, MIP-1 alpha, and MIP-1 beta are major HIV-suppressive factors produced by CD8-positive T-cells.  (from OMIM 182283 and NCI)
C24783	CCL3L1_Gene	CC_Cytokine_Gene	CCL3L1 Gene|464.2|CCL3L1|Chemokine (C-C Motif) Ligand 3-Like 1 Gene|G0S19-2|LD78|LD78BETA|PAT 464.2|SCYA3L|SCYA3L1	The CCL3L1 gene encodes Chemokine (C-C Motif) Ligand 3-Like 1, which belongs to an intercrine beta family. This signaling cytokine attracts and activates leukocytes, and has an anti-HIV-1 activity. It is implicated in cell cycle and signal transduction. (from http://www.dsi.univ-paris5.fr/genatlas/fiche.php?n=2076)
C24784	CCL4_Gene	CC_Cytokine_Gene	CCL4 Gene|ACT2|AT744.1|Act-2|CCL4|Chemokine (C-C Motif) Ligand 4 Gene|LAG1|MIP-1-beta|MIP1B|SCYA4	Induced rapidly after T-cell (phytohemagglutinin, mitogens), B-cell, and monocyte (lipopolysaccharide) activation, human CCL4 Gene (Intercrine Beta Family) encodes secreted homodimeric chemotactic Small Inducible Cytokine A4, which binds to CCR5 and CCR8 in inflammatory processes. Separated by 14-kb, the head-to-head MIP-1-alpha and MIP-1-beta genes (two copies each) demonstrate parallel regulation and encode proteins with 55% sequence similarity. RANTES, MIP-1-alpha, and MIP-1-beta are major HIV-suppressive factors produced by CD8+ T cells. (NCI)
C24785	CCL5_Gene	CC_Cytokine_Gene	CCL5 Gene|CCL5|Chemokine (C-C Motif) Ligand 5 Gene|D17S136E|MGC17164|RANTES|SCYA5|SIS-delta|SISd|TCP228	This gene encodes a small inducible cytokine A5 which is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor CCR5 and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. (from LocusLink)
C24786	CCL7_Gene	CC_Cytokine_Gene	CCL7 Gene|CCL7|Chemokine (C-C Motif) Ligand 7 Gene|FIC|MARC|MCP-3|MCP3|NC28|SCYA7	The CCL7 gene encodes Small Inducible Cytokine A7, a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. This gene is part of a cluster of C-C chemokine family members on chromosome 17q. (from LocusLink)
C24787	CCL8_Gene	CC_Cytokine_Gene	CCL8 Gene|CCL8|HC14|MCP-2|MCP2|SCYA10|SCYA8	This gene encodes a small inducible cytokine A8 which displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. (from LocusLink)
C24788	CXCL10_Gene	CXC_Cytokine_Gene	CXCL10 Gene|C7|CRG-2|CXCL10|Chemokine (C-X-C Motif) Ligand 10 Gene|IFI10|INP10|IP-10|MOB-1|SCYB10|gIP-10	Induced by Interferon Gamma, human CXCL10 Gene (Intercrine Alpha/Chemokine CXC Family) at 4q21 encodes secreted 98-aa 11-kD (precursor) Small Inducible Cytokine B10, a chemotactic chemokine ligand for receptor CXCR3 that causes stimulation of monocyte, natural killer cell, and T-cell migration, and modulation of adhesion molecule expression. (NCI)
C24789	CXCL11_Gene	CXC_Cytokine_Gene	CXCL11 Gene|CXCL11|Chemokine (C-X-C Motif) Ligand 11 Gene|H174|I-TAC|IP-9|IP9|SCYB11|SCYB9B|b-R1	Induced by INF gamma and INF beta in leukocytes, pancreas, liver, astrocytes, thymus, spleen, lung, placenta, prostate, small intestine, and keratinocytes, 4-exon human CXCL11 Gene (Intercrine Alpha/Chemokine CXC Family) at 4q21.2 encodes secreted 94-aa 10-kD (precursor) Small Inducible Cytokine B11, a chemotactic ligand for 7-transmembrane, G protein-coupled receptor CXCR3 that regulates activated T cell response. (NCI)
C24790	CXCL13_Gene	CXC_Cytokine_Gene	CXCL13 Gene|ANGIE|ANGIE2|BCA-1|BCA1|BLC|BLR1L|CXCL13|Chemokine (C-X-C Motif) Ligand 13 Gene|SCYB13	Expressed in liver, spleen, lymph node, Peyer's patches, appendix, stomach, salivary gland, mammary gland, and fetal spleen, human CXCL13 Gene (Intercrine Alpha/Chemokine CXC Family) at 4q21 encodes secreted 109-aa 13-kD (precursor) Small Inducible Cytokine B13, which binds to BLR1/CXCR5 and promotes migration and chemotaxis of B lymphocytes expressing BLR-1. It may function in B lymphocyte homing to follicles. (NCI)
C24791	CXCL14_Gene	CXC_Cytokine_Gene	CXCL14 Gene|BMAC|BRAK|Bolekine|CXCL14|Chemokine (C-X-C Motif) Ligand 14 Gene|KEC|KS1|MGC10687|MIP-2g|NJAC|SCYB14	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas, human CXCL14 Gene (Intercrine Alpha/Chemokine CXC Family) at 5q31 encodes secreted immunoregulatory 99-aa 12-kD (precursor) Small Inducible Cytokine B14, chemotactic for monocytes and likely involved in monocyte-derived macrophage homeostasis.  (NCI)
C24792	CXCL5_Gene	CXC_Cytokine_Gene	CXCL5 Gene|CXCL5|Chemokine (C-X-C Motif) Ligand 5 Gene|ENA-78|ENA78|SCYB5	Encodes Epithelial Neutrophil Activating Peptide 78, a 78 amino acid member of the CXC family of chemokines that is produced and secreted upon stimulation by interleukin 1 (IL1B) or tumor necrosis factor alpha.  Stimulates chemotactic migration of neutrophils, monocytes, lymphocytes, and fibroblasts.
C24793	CXCL6_Gene	CXC_Cytokine_Gene	CXCL6 Gene|CKA-3|CXCL6|Chemokine (C-X-C Motif) Ligand 6 Gene|GCP-2|GCP2|SCYB6	Human CXCL6 Gene (Intercrine Alpha/Chemokine CXC Family) at 4q21 encodes secreted 114-aa 12-kD (precursor) Small Inducible Cytokine B6, a potent inflammatory mediator and chemotactic factor for neutrophilic granulocytes that regulates leukocyte trafficking through interactions with a subset of 7-transmembrane, G protein-coupled receptors CXCR1 and CXCR2 and activates gelatinase B (MMP9) release from granulocytes. Human and bovine GCP2 are 67% identical at the amino acid level. (NCI)
C24794	XCL1_Gene	Cytokine_Gene	XCL1 Gene|ATAC|Chemokine (C Motif) Ligand 1 Gene|LPTN|LTN|SCM-1|SCM-1a|SCM1|SCYC1|XCL1	Expressed (0.8-kb mRNA) in activated CD8+ T cells, in spleen, thymus, small intestine, lung, prostate, and ovary, 3-exon human XCL1 Gene (Intercrine Gamma Family) encodes 114-aa 12.5-kDa (precursor) secreted Small Inducible Cytokine C1, similar to CCL8 and CCL3, but lacking the first and third cysteines of CC and CXC chemokines. XCL1 differs from XCL2 (separate gene) by only 2 amino acids; XCL1 encodes Asp7, Lys8 (mature protein) instead of His, Arg as in XCL2. XCL1 is chemotactic for CD4+ and CD8+ T cells, but not for monocytes or neutrophils, and induces increased intracellular calcium in peripheral lymphocytes; XCL1 induces migration of cells expressing XCR1. Small (8-14 kD), mostly basic, chemokines interact with 7-transmembrane G protein-coupled receptors and regulate cell trafficking of leukocytes, as well as development, homeostasis, and immune system function. (NCI)
C24795	XCL2_Gene	Cytokine_Gene	XCL2 Gene|Chemokine (C Motif) Ligand 2 Gene|SCM-1b|SCM1B|SCYC2|XCL2	Expressed, like XCL1, in activated T cells (low levels in unstimulated cells), 3-exon human XCL2 Gene (Intercrine Gamma Family) encodes 114-aa 12.5-kDa (precursor) secreted Chemokine (C Motif) Ligand 2, most homologous to CCL8 and CCL3 chemokines, but lacking the first and third cysteines characteristic of CC and CXC chemokines and chemotactic for lymphocytes, but not for monocytes or neutrophils. XCL2 differs from XCL1 (a separate gene product) by only 2 amino acids; XCL2 encodes His7 and Arg8 (mature protein) instead of Asp and Lys as in XCL1. XCL2 induces migration of cells expressing XCR1. Small (8-14 kD), mostly basic, chemokines interact with 7-transmembrane G protein-coupled receptors and regulate cell trafficking of leukocytes, as well as development, homeostasis, and immune system function. (NCI)
C24796	CX3CL1_Gene	Cytokine_Gene	CX3CL1 Gene|ABCD-3|C3Xkine|CX3CL1|CX3CR1|CXC3|CXC3C|Chemokine (C-X3-C Motif) Ligand 1 Gene|NTN|NTT|SCYD1	This gene encodes small inducible cytokine D1 that is the first member of a fourth branch of the chemokine superfamily. The expression of this cytokine in microglia, endothelial and fibroblastic cells is upregulated by inflammatory signals.
C24797	CXCL12_Gene	CXC_Cytokine_Gene	CXCL12 Gene|CXCL12|Chemokine (C-X-C Motif) Ligand 12 Gene|PBSF|SCYB12|SDF-1A|SDF-1B|SDF1|SDF1A|SDF1B|TLSF-A|TLSF-B|TPAR1	The 10-kb human CXCL12 Gene (Intercrine Alpha/Chemokine CXC Family) at 10q11.1 encodes alternatively spliced alpha and beta isoforms of secreted 93-aa 11-kD (precursor) Stromal Cell-Derived Factor 1, a chemoattractant ligand for CXCR4 on T-lymphocytes and monocytes. The beta form contains additional sequence from exon 4. SDF1 is cleaved of an N-terminal tetrapeptide by MMP2 and loses CXCR4 affinity. Human and mouse protein sequences are nearly 92% identical. SDF1 induces intracellular actin polymerization in lymphocytes and may regulate immune surveillance and extravasation of lymphocytes and monocytes rather than in inflammation. With CD4, SDF1 is a coreceptor on CD4+ lymphocytes for HIV-1. (NCI)
C24798	SECTM1_Gene	Transmembrane_Protein_Gene	SECTM1 Gene|K12|SECTM1|Secreted and Transmembrane 1 Gene	This gene encodes a transmembrane and secreted protein with characteristics of a type 1a transmembrane protein. It is found in a perinuclear Golgi-like pattern and thought to be involved in hematopoietic and/or immune system processes. (LocusLink)
C24799	SEMA3E_Gene	Signaling_Pathway_Gene	SEMA3E Gene|KIAA0331|M-SEMAH|M-Sema H|M-SemaK|SEMA3E|SEMAH|Sema Domain, Immunoglobulin Domain (Ig), Short Basic Domain, Secreted, (Semaphorin) 3E Gene|coll-5	Human SEMA3E Gene (Semaphorin Family) at 7q21.11 encodes 775-aa 89-kDa (precursor) secreted Semaphorin 3E, a signaling protein containing a Sema domain and an Ig-like C2-type domain. (NCI)
C24800	SERPINI2_Gene	Proteinase_Inhibitor_Gene	SERPINI2 Gene|MEPI|PANCPIN|PI14|SERPIN12|SERPINI2|Serine (or Cysteine) Proteinase Inhibitor, Clade I (Pancpin), Member 2 Gene|TSA2004	Expressed in pancreas and adipose tissues, 8-exon human SERPINI2 Gene (PAI-1 Serpin Family) at 3q26.1-q26.2 encodes 405-aa 46-kDa (precursor) secreted Protease Inhibitor 14, containing a signal peptide, 3 cysteine residues, and 3 potential N-glycosylation sites. SERPINI2 may have a role in a growth-control, possibly growth-suppression. (NCI)
C24801	SET_Gene	Enzyme_Inhibitor_Gene	SET Gene|2PP2A|I2PP2A|PHAPII|SET|SET Translocation (Myeloid Leukemia-Associated) Gene|TAF-IBETA	Expressed in all tissues and responsive to serum factors, contact inhibition, or differentiation, human SET Gene (NAP Family) at 9q34 encodes 277-aa 32-kDa nuclear Phosphatase 2A Inhibitor I2PP2A, a specific inhibitor of PP2A that may be involved in intracellular signaling after ligand activation of HLA class II molecules. Serine phosphorylated SET has a long acidic C-terminus and SET domain. Located in an ER-associated complex containing pp32, HMG2, and APE1, SET is a specific inhibitor of GZMA-activated DNase/nucleoside diphosphate kinase (GAAD/NM23H1), which mediates GZMA-induced caspase-independent apoptosis characterized by single-stranded DNA nicks. GZMA cleavage of SET releases NM23H1 from bound inhibition to SET and results in SET degradation, NM23H1 translocation to the nucleus, and NM23H1 nicking of DNA. (NCI)
C24802	SETDB1_Gene	Methyltransferase_Gene	SETDB1 Gene|ESET|KG1T|KIAA0067|SET Domain, Bifurcated 1 Gene|SETDB1	Widely expressed (high in testis) human SETDB1 Gene (Suvar3-9 Family) at 1q21 encodes 2 alternative isoforms of 1291-aa 143-kDa nuclear Histone H3-K9 Methyltransferase 4. Excluded from nucleoli and condensed chromatin, SETDB1 methylates histone H3 Lys-9 in epigenetic transcriptional repression that recruits HP1 proteins to methylated histones. SETDB1 contains an MBD domain, a pre-SET, a SET, and a post-SET domain, and 2 Tudor domains; pre-SET, SET and post-SET are required for methyltransferase activity. Isoform 2 lacks all methyltransferase domains. The conserved SET domain is implicated in transcriptional modulation of active or repressed chromatin through remodeling. Targeted to histone by TRIM28/TIF1B, SETDB1 contributes to euchromatic gene silencing by KRAB zinc-finger proteins and may interact with ERG. (NCI)
C24803	SFN_Gene	Cell_Cycle_Gene	SFN Gene|14-3-3 Sigma Gene|14.3.3 Sigma Gene|HME1|SFN|Stratifin Gene	The 14-3-3 sigma gene encodes a putative cytoplasmic, p53-regulated homodimeric inhibitor of G2/M progression that is over expressed in squamous cell carcinoma of the head and neck.  The gene is a member of a large 14-3-3 gene family. The product is also called stratifin or HME1.
C24804	SFRP4_Gene	Signaling_Pathway_Gene	SFRP4 Gene|FRP-4|SFRP4|Secreted Frizzled-Related Protein 4 Gene|frpHE	Human SFRP4 Gene (SFRP Family) at 7p14.1 encodes Secreted Frizzled-Related Protein 4, a soluble modulator of WNT signaling that contains an N-terminal signal peptide, no transmembrane domain, a hydrophilic C terminus, and a Cys-rich domain homologous to the putative WNT-binding site of Frizzled proteins. Involved in cytoskeletal regulation, apoptosis, and proliferation, WNT-mediated simulation of 'Frizzled' receptors can activate beta-catenin, MAPK kinase, and G protein pathways. Bound to WNTs or frizzled receptors, secreted frizzled-related proteins antagonize WNT/frizzled pathways. SFRP4 may inhibit WNT8-mediated development of secondary axes. (NCI)
C24805	SH2B_Gene	Adaptor_Signaling_Protein_Gene	SH2B Gene|DKFZP547G1110|SH2-B|SH2-B Homolog Gene|SH2B	Human SH2B Gene at 16p12.2 encodes SH2-B Homolog, similar to rat (FceRI gamma-chain interacting protein) SH2-B and may be involved in hormone and cytokine cellular signaling pathways. (NCI)
C24806	SH2D3A_Gene	Adaptor_Signaling_Protein_Gene	SH2D3A Gene|NSP1|SH2 Domain Containing 3A Gene|SH2D3A	Expressed in placenta, pancreas, kidney, lung, fetal kidney, and fetal lung as a 2.7-kb transcript, human SH2D3A Gene at 19p13.3 encodes 76-aa 64-kD adaptor protein SH2 Domain Containing Protein 3A, containing a potential SH3 interaction domain. Insulin or EGF induce rapid tyrosine phosphorylation of SH2D3A and increased association with p130-Cas. SH2D3A appears to mediate activation of stress-activated JNK1, but not MAPK1. (NCI)
C24807	SH2D3C_Gene	Adaptor_Signaling_Protein_Gene	SH2D3C Gene|NSP3|SH2 Domain Containing 3C Gene|SH2D3C	Expressed in a variety of tissues as 3.2- and 3.8-kb transcripts, human SH2D3C Gene at 9q34.11 encodes 698-aa SH2 Domain Containing Protein 3C, a putative adaptor protein containing a potential SH3 interaction domain that may link integrin and tyrosine kinase receptors to the JNK/SAPK pathway. (NCI)
C24808	SHC1_Gene	Adaptor_Signaling_Protein_Gene	SHC1 Gene|SHC|SHC (Src Homology 2 Domain Containing) Transforming Protein 1 Gene|SHC1|SHCA	Widely expressed as 3 isoforms, p66SHC, p52SHC and p46SHC, by alternative initiation, human SHC1 Gene at 1q21 encodes 583-aa 63-kDa (precursor) cytoplasmic SH2 Domain Containing Transforming Protein 1, a growth factor receptor adaptor protein containing collagen homology, SH2, SH3, and PID/PTB domains involved in many RAS mitogenic signal transduction pathways. p46, p52, and p66 differ in the N terminals. The PID domain specifically and rapidly binds to the Asn-Pro-Xaa-Tyr(P) motif of tyrosine-phosphorylated proteins. SHC1 is phosphorylated by activated growth factor receptor tyrosine kinases. p66, tyrosine phosphorylated by activated growth factor receptors, complexes with GRB2, an adaptor protein for RAS exchange factor SOS. (NCI)
C24809	SHC3_Gene	Adaptor_Signaling_Protein_Gene	SHC3 Gene|N-Shc|NSHC|SHC3|SHCC|Src Homology 2 Domain Containing Transforming Protein C3 Gene	Expressed in the brain as a 10-kb transcript, human SHC3 Gene at 9q22.1 encodes 474-aa 52-kD and 594-aa 64-kD isoforms of Neuronal SHC, similar to SHC; nearly 70% homology in the PTB and SH2 domains. SHC3 appears involved in signaling from BDNF/TRKB to the RAS/MAPK pathway. BDNF induces tyrosine phosphorylation of SHC3 and binding to TRKB. Activated EGFR also interacts with and tyrosine-phosphorylates SHC3, inducing an association with GRB2. SHC3 and SCK mediate EGF signaling, but SHC3 has a higher affinity for TRKA and TRKB. (NCI)
C24810	SHH_Gene	Signaling_Pathway_Gene	SHH Gene|HHG1|HLP3|HPE3|SHH|SMMCI|Sonic Hedgehog Homolog (Drosophila) Gene	Expressed only during embryogenesis, human SHH Gene (Hedgehog Family) at 7q36 encodes 462-aa 50-kDa (precursor) Sonic Hedgehog Homolog, the notochord inductive signal in ventral neural tube and somite patterning and the polarizing signal for anterior-posterior limb axis patterning. The C-terminal domain displays precursor processing autoproteolytic activity that generates the soluble signaling N-portion. With transferase activity, the C-portion covalently attaches cholesterol to the new N-product C-terminus, restricting it to the cell surface and regulating distribution of protein activity throughout the embryo. SHH binds to PTC receptor, releasing constitutive SMO repression and activating target gene transcription. Defects in SHH cause HPE3. (NCI)
C24811	SIRPB1_Gene	Immunoglobulin_Family_Gene	SIRPB1 Gene|SIRP-BETA-1|SIRPB1	Expressed as 2 alternative isoforms in monocytes and dendritic cells, human SIRPB1 Gene (SIRPB Family/Ig Family) at 20p13 encodes N-glycosylated 398-aa 43-kDa (precursor) type I membrane protein Signal-Regulatory Protein Beta 1, a cell surface Ig-like transmembrane receptor glycoprotein containing an IgV-type domain and 2 IgC1-type domains involved in negative regulation of receptor tyrosine kinase-coupled signaling. Unlike SIRPAs, SIRPB1 lacks a C-terminal cytoplasmic SHP2-binding domain. SIRPB1 interacts with ITAM protein TYROBP/DAP12, resulting in SYK tyrosine kinase recruitment. (NCI)
C24812	SKIL_Gene	Transcription_Corepressor_Gene	SKIL Gene|SKI-Like Gene|SKIL|SNO	Widely expressed with immediate early kinetics upon serum stimulation, human SKIL Gene at 3q26 encodes alternative isoforms of SKI-Like Protein SKIL: SNON (684-aa), SNOA (415-aa), SNON2, SNOI (skeletal muscle restricted). A component of the TGFB/SMAD pathway, SNON interacts with SMAD2/3 and regulates cell growth and cell differentiation signaling. Absent TGFB, SNON binds nuclear SMAD4 and represses target gene promoter activity. APC activator CDH1 forms a complex with SNON, SMAD3, and TGFB-regulated ubiquitin ligase APC, regulating SNON degradation. TGFB activates SMAD2/3/4 nuclear translocation. SNON degradation allows SMAD2/4 to activate TGFB target genes. TGFB also induces SNON expression, which binds to SMAD complexes and shuts off TGFB signaling. (NCI)
C24813	SKIV2L_Gene	Helicase_Gene	SKIV2L Gene|DDX13|HLP|SKI2|SKI2W|SKIV2|SKIV2L|Superkiller Viralicidic Activity 2-Like (S. cerevisiae) Gene	This gene encodes a DEAD box protein which a ATP-dependent RNA helices, may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. This gene consists of 28 exons and the gene is located in the class III region of the major histocompatibility complex. (LocusLink)
C24814	SKP2_Gene	Cell_Cycle_Gene	SKP2 Gene|FBL1|FBXL1|FLB1|MGC1366|S-Phase Kinase-Associated Protein 2 Gene|SKP2	Expressed as 3 alternative isoforms, alpha (42-aa 48-kDa), beta (410-aa), and gamma (442-aa), human SKP2 Gene (F-Box Family) at 5p13 encodes S-Phase Kinase-Associated Protein 2, containing an F-box domain and 10 tandem LRR repeats. SKP2 acts as a substrate recognition component of the SCF E3 ubiquitin ligase complex, which mediates ubiquitination and proteasomal degradation of target proteins involved in cell cycle progression, signal transduction, and transcription. SKP2 interacts with CUL1, SKP1, and CKS1, and with the Cyclin A/CDK2 complex as an essential element of Cyclin A/CDK2 S-Phase Kinase. Involved in the G1/S transition, SKP2 specifically recognizes phosphorylated CDKN1B/p27KIP predominantly in S phase and interacts with S-phase p19SKP1. CDKN1B/p27KIP degradation also requires CKS1. (NCI)
C24815	SLC26A3_Gene	Ion_Channel_Protein_Gene	SLC26A3 Gene|CLD|DRA|SLC26A3|Solute Carrier Family 26, Member 3 Gene	Human SLC26A3 Gene (SLC26A/SulP Transporter Family) encodes 764-aa 85-kDa Chloride Anion Exchanger, a sulfate/chloride/bicarbonate transmembrane glycoprotein exchange transporter containing 1 STAS domain and localized in lower intestinal columnar epithelial apical membranes and some goblet cells. Involved in absorbtion, SLC26A3 mediates electrolyte and fluid absorption. Defects in SLC26A3 are the cause of congenital chloride diarrhea (CLD). (NCI)
C24816	SLI_Gene	Adaptor_Signaling_Protein_Gene	SHC2 Gene|SCK|SHC (Src Homology 2 Domain Containing) Transforming Protein 2 Gene|SHC2|SHCB|SLI	Broadly expressed as a 2.7-kb transcript (highest in liver, pancreas, prostate, ovary, and brain), human SLI Gene at 19p13.3 encodes 489-aa Neuronal SHC Adaptor Homolog, containing a conserved N-terminal PTB domain, a CH domain, and a conserved C-terminal SH2 domain, as well as unique proline-rich motifs that may be SH3 recognition sites. SCK and NSHC mediate EGF signaling and both bind to neurotrophic receptors TRKA and TRKB. SCK appears to specifically associate with cytoplasmic c-SRC tyrosine kinase CSK (phosphorylated by SRC), which downregulates c-SRC kinase through C-terminal tyrosine phosphorylation. (NCI)
C24817	SMO_Gene	G_Protein-Coupled_Receptor_Gene	SMO Gene|Gx|SMO|SMOH|Smoothened Homolog (Drosophila) Gene	The protein encoded by this gene appears to be 7-transmembrane G protein-coupled receptor. Seems to form a complex with PTCH, playing a role in the sonic hedgehog signaling pathway. (from OMIM)
C24818	SNK_Gene	Serine-Threonine_Protein_Kinase_Gene	PLK2 Gene|Polo-Like Kinase 2 (Drosophila) Gene|SNK|SNK Gene	Serum-inducible kinase is a member of the 'polo' family of serine/threonine protein kinases that have a role in normal cell division. Highly similar to cytokine-inducible serine/threonine kinase (CNK); may be involved in the regulation of cell cycle progression (OMIM, LocusLink)
C24819	FRS2_Gene	Adaptor_Signaling_Protein_Gene	FRS2 Gene|FRS2|FRS2A|FRS2alpha|Fibroblast Growth Factor Receptor Substrate 2 Gene|SNT|SNT-1	Human FRS2 Gene at 12q15 encodes 508-aa 56.8-kD FGFR Signalling Adaptor, containing a myristylation sequence, a PTB domain, and 4 potential GRB2-binding sites. FGFR-mediated tyrosine-phosphorylated FRS2 binds directly to FGFR1 and to GRB2/SOS in response to FGF or NGF stimulation. FRS2 myristylation is essential for membrane localization, tyrosine phosphorylation, GRB2/SOS recruitment, and MAP kinase activation. FRS2A is threonine phosphorylated by MAPK in response to FGF insulin, EGF, and PDGF. FRS2 may function as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF stimulation to link receptor activation with MAPK and other signaling pathways essential for cell growth and differentiation.  (NCI)
C24820	FRS3_Gene	Adaptor_Signaling_Protein_Gene	FRS3 Gene|FRS2B|FRS2beta|FRS3|Fibroblast Growth Factor Receptor Substrate 3 Gene|MGC17167|SNT-2|SNT2	The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras. (LocusLink)
C24821	SNW1_Gene	Transcription_Coactivator_Gene	SKIIP Gene|NCOA-62|SKI Interacting Protein Gene|SKIIP|SKIP|SNW1	This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also interact with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity. (LocusLink)
C24822	SRP19_Gene	Trafficking_Protein_Gene	SRP19 Gene|SRP19|Signal Recognition Particle 19kDa Gene	Expressed as a 0.9-kb transcript, 5-exon human SRP19 Gene (SRP19 Family) at 5q21-q22 between DP1 and DP2.5 encodes 144-aa cytoplasmic Signal Recognition Particle 19kDa, with 7 C-terminal Lys interrupted by 2 Gly residues and involved in signal-recognition-particle assembly (SRP). Monomeric SRP19 mediates binding of the monomeric 54-kDa subunit and binds directly to the SRP 7SLRNA helix 6 stem-loop structure. Mediating signal recognition, translational arrest, and ER targeting by docking protein interaction, the SRP complex consists of a 7SLRNA and SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72 protein subunits. SRP9/SRP14 (Alu domain) and SRP68/SRP72 (S domain) bind to 7SLRNA as heterodimers. (NCI)
C24823	SRPUL_Gene	Gene_with_Unknown_or_Unclassified_Function	SRPX2 Gene|SRPUL|SRPX2|Sushi-Repeat Protein Upregulated in Leukemia Gene|Sushi-Repeat-Containing Protein, X-Linked 2 Gene	Human SRPUL Gene at Xq21.33-q23 encodes Sushi-Repeat Protein. (NCI)
C24824	SSH3BP1_Gene	Adaptor_Signaling_Protein_Gene	ABl1 Gene|ABI-1|ABI1|ABL-Interactor 1 Gene|E3B1|NAP1|SSH3BP1|SSH3BP1 Gene	Human SSH3BP1 Gene at 10p11.2 encodes Spectrin SH3 Domain Binding Protein 1, containing similarity to homeotic proteins, several polyproline stretches, and a C terminal SH3 domain required for binding to ABL proteins. Binding SH3 domains of EPS8, SSH3BP1 adaptor protein holds EGFR substrate EPS8 in complex with SOS1, mediating RAS signal transduction to RAC (activation) by regulating RAC-specific GEF activity. Depending on its association with SSH3BP1 or RNTRE, EPS8 participates in EGFR signaling through RAC or in EGFR trafficking through RAB5. EPS8 interacts through its SH3 domain with the EGFR-regulated RAB5 GAP RNTRE, which inhibits EGFR internalization. EPS8 diversion from RAC-activation by RNTRE, results in RAC signaling attenuation. (NCI)
C24825	SSPN_Gene	Transmembrane_Protein_Gene	SSPN Gene|KRAG|SPN1|SPN2|SSPN|Sarcospan (Kras Oncogene-Associated Gene) Gene	SSPN gene is expressed in a variety of tissues with highest levels in muscle, where alternative splice variants have been observed. In certain tumors KRAS2, SSPN, and ITPR2 are coamplified.  Part of the dystrophin-glycoprotein complex of the muscle sarcolemma.  The function of this gene is unknown. (LocusLink)
C24826	SST_Gene	Peptide_Hormone_Gene	SST Gene|SMST|SST|Somatostatin Gene	Expressed primarily by the hypothalamic median eminence and by pancreatic delta cells, human SST Gene (Somatostatin Family) at 3q28 encodes secreted 116-aa 13-kDa (precursor) Somatostatin, an important cyclic tetradecapeptide regulator of endocrine and nervous system function. Somatostatin inhibits release of adenohypophyseal GH, thyrotropin, and corticotropin, pancreatic insulin and glucagon, gastric mucosal gastrin, intestinal mucosal secretin, and renal renin by binding to specific high-affinity cell surface G protein-coupled receptors expressed in a tissue-specific manner. (NCI)
C24827	SSTR1_Gene	G_Protein-Coupled_Receptor_Gene	SSTR1 Gene|SRIF-2|SSTR1|Somatostatin Receptor 1 Gene	Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR1 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in jejunum and stomach. (LocusLink)
C24828	SSTR3_Gene	G_Protein-Coupled_Receptor_Gene	SSTR3 Gene|SSTR3|Somatostatin Receptor 3 Gene	Somatostatin binds to a group of structurally related tissue-specific high-affinity integral membrane GPCRs (family 1), coupled via G proteins to inhibition of adenylyl cyclase.  Somatostatin Receptor 3 is readily detected in brain, pituitary, and pancreatic islets.  (from OMIM 182453, SWISS-PROT P32745, and NCI)
C24829	SSTR4_Gene	G_Protein-Coupled_Receptor_Gene	SSTR4 Gene|SSTR4|Somatostatin Receptor 4 Gene	Expressed in fetal and adult brain, lung, stomach, kidney, pituitary, and adrenals as an 1,167-bp open reading frame, human SSTR4 Gene (GPCR1 Family) at 20p11.2 encodes 388-aa 42-kDa Somatostatin Receptor 4, a tissue-specific high-affinity integral membrane protein receptor for somatostatin-14 functionally coupled to adenylate cyclase inhibition by G proteins and to activation of both arachidonate release and MAP kinase cascade. Having strong sequence identity with SSTR1, SSTR2, and SSTR3, SSTR4 mediates the antiproliferative action of somatostatin. (NCI)
C24830	ST13_Gene	Regulatory_Gene	ST13 Gene|FAM10A1|HIP|HOP|HSPABP|HSPABP1|Heat Shock 70kD Protein Binding Protein Gene|P48|PRO0786|SNC6|ST13|Suppression of Tumorigenicity 13 (Colon Carcinoma) (Hsp70 Interacting Protein) Gene	The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that is a candidate tumor suppressor gene (LocusLink)
C24831	STAT1_Gene	Signal_Transducer_and_Activator_of_Transcription_Family_Gene	STAT1 Gene|ISGF-3|STAT1|STAT91	The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. (LocusLink)
C24832	STAT2_Gene	Signal_Transducer_and_Activator_of_Transcription_Family_Gene	STAT2 Gene|ISFG-3|ISGF-3|P113|STAT113|STAT2	The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Three alternatively spliced transcript variants have been reported, the full length nature is not known for two of them. (LocusLink)
C24833	STAT3_Gene	Signal_Transducer_and_Activator_of_Transcription_Family_Gene	STAT3 Gene|APRF|STAT3	The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Two alternatively spliced transcript variants encoding distinct isoforms have been described. (LocusLink)
C24834	STAT5A_Gene	Signal_Transducer_and_Activator_of_Transcription_Family_Gene	STAT5A Gene|MGF|STAT5|STAT5A	The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests an antiapoptotic function of this gene in cells. (LocusLink)
C24835	STAT6_Gene	Signal_Transducer_and_Activator_of_Transcription_Family_Gene	STAT6 Gene|D12S1644|IL-4-STAT|STAT6|STAT6B|STAT6C	The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. (LocusLink)
C24836	STC1_Gene	Peptide_Hormone_Gene	STC1 Gene|STC|STC1|Stanniocalcin 1 Gene	Expressed as a 4-kb, and a less abundant 2-kb, mRNA in most tissues (ovary, prostate, heart, kidney, and thyroid highest), 4-exon 13-kb human STC1 Gene (Stanniocalcin Family) at 8p21-p11.2 encodes 247-aa 28-kDa (precursor) secreted Stanniocalcin 1, a homodimeric 35-kD glycoprotein hormone involved in calcium homeostasis and renal phosphate reabsorption. In kidney, expression is confined to the distal convoluted tubule and the collecting tubule. STC1 is 96% identical to mouse protein and 73% similar to fish STC. Serine phosphorylation by PKC may regulate activity. Ovarian STC may signal between thecal-interstitial cells and the corpus luteum and oocyte. (NCI)
C24837	STC2_Gene	Peptide_Hormone_Gene	STC2 Gene|STC-2|STC2|STCRP|Stanniocalcin 2 Gene	Widely expressed as multiple transcripts in muscle and heart (strongest), pancreas, kidney, spleen, prostate, small intestine, colon, and peripheral leucocytes, 4-exon human STC2 Gene (Stanniocalcin Family) at 5q35.2 encodes 302-aa Stanniocalcin 2, a constitutively secreted disulfide-linked homodimeric 32-kD protein that regulates calcium and phosphate homeostasis. STC2 and STC1 exon-intron boundaries are completely conserved. STC2 shares 34% identity with STC1; human and mouse proteins are nearly 88% identical. A Cys-rich N-terminal region may mediate homodimerization. STC2 function on kidney phosphate transport appears to be opposite STC1. STC2 may be serine phosphorylated by a casein kinase-2 ecto-protein. STC2 is likely phosphorylated on serine 288. Phosphorylation may regulate calcium and phosphate homeostasis activity. (NCI)
C24838	STK15_Gene	Serine-Threonine_Protein_Kinase_Gene	STK6 Gene|AIK|ARK1|AURORA2|BTAK|STK15|STK15 Gene|STK6|Serine/Threonine Kinase 6 Gene	Expressed as multiple transcript variants that encode the same protein in testis, skeletal muscle, thymus, and spleen, human STK6 Gene (Aurora Ser/Thr Kinase Family) at 20q13.2-q13.3 encodes 403-aa 45.8-kDa Serine/Threonine Kinase 6, a phosphorylated cell cycle-regulated kinase localized on centrosomes in interphase cells and at spindle poles in mitosis. Cell cycle-regulated expression accumulates in G2/M and decrease rapidly thereafter. STK6 appears to be involved in cell cycle-regulated microtubule formation and/or stabilization of the spindle pole region during chromosome segregation in anaphase and telophase. STK6 defects are responsible for centrosome aberrations, including aneuploidy. (NCI)
C24839	STK6_Gene	Retired_Concepts	STK6 Gene|AIK|BTAK|STK15|STK6
C24840	SUI1_Gene	Translation_Process_Gene	SUI1 Gene|A121|ISO1|Putative Translation Initiation Factor Gene|SUI1	Human SUI1 Gene (SUI1 Family) at 17q21.2 encodes 113-aa 12.7-kDa Protein Translation Factor SUI1 Homolog, a putative negative growth regulator likely involved in translation. (NCI)
C24841	TACC3_Gene	Gene_with_Unknown_or_Unclassified_Function	TACC3 Gene|ERIC1|TACC3|Transforming, Acidic, Coiled-Coil-Containing Protein 3 Gene	The function of this gene has not yet been determined; however, it is speculated that it may be involved in cell growth and differentiation. Expression of this gene is up-regulated in some cancer cell lines, and in embryonic day 15 in mice. (LocusLink)
C24842	TACR3_Gene	G_Protein-Coupled_Receptor_Gene	TACR3 Gene|NK3R|TAC3RL|TACR3|Tachykinin Receptor 3 Gene	This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B. (LocusLink)
C24843	TAL2_Gene	Transcription_Factor_Gene	TAL2 Gene|T-Cell Acute Lymphocytic Leukemia 2 Gene|TAL2	Human TAL2 Gene at 9q32 (33-kb from the t(7;9)(q34;q32) breakpoint specifically associated with T-ALL) encodes 108-aa 12-kDa bHLH T-Cell Acute Lymphocytic Leukemia 2 Protein, with sequence homology to TAL1 and LYL1, bHLH proteins involved in T-cell leukemogenesis. TAL2 also includes a DNA-binding domain homologous to those in TAL1 and LYL1. t(7;9)(q34;q32) results from a mistake during V(D)J recombination using a fortuitous 3-prime TAL2 recombination site and the TCRB J-beta-2 coding segment that juxtaposes TAL2 with the TCR-beta enhancer and results in TAL2 overexpression. (NCI)
C24844	TAZ_Gene	Transcription_Coactivator_Gene	WWTR1 Gene|DKFZP586I1419|TAZ|WW Domain Containing Transcription Regulator 1 Gene|WWTR1	With highest expression of a 6-kb transcript in kidney, heart, placenta, and lung, human TAZ Gene encodes 400-aa 45-kDa Transcriptional Coactivator with PDZ-Binding Motif, containing a putative N-terminal 14-3-3 protein-binding motif, a central WW domain, and a C-terminal PDZ-binding motif and 2-stranded coiled-coil. The PDZ-binding domain localizes TAZ to discrete nuclear foci and is required for TAZ-stimulated gene transcription; it also mediates TAZ interaction with SLC9A3R2. Interaction with 14-3-3 appears to require TAZ phosphorylation on a specific serine residue; phosphorylation reduces TAZ transcriptional coactivation by inducing nuclear export through interaction with 14-3-3. TAZ shares 91% identity with mouse Taz and 45% identity with YAP. (NCI)
C24845	TBK1_Gene	Serine-Threonine_Protein_Kinase_Gene	TBK1 Gene|FLJ11330|NAK|NF-Kb-Activating Kinase Gene|T2K|TANK-Binding Kinase 1 Gene|TBK1	This gene encodes a protein that is similar to I-kappa-B (IKB) kinases, which phosphorylate IKB proteins.  IKB proteins inactivate NF-kappa-B (NFKB) complex of proteins by trapping it in the cytoplasm.  Initiation of IKB proteins degradation (via ubiquitination pathway) was marked by phosphorylation on serine residues by IKB kinases, thereby allowing activation and nuclear translocation of the NFKB complex. TANK Binding Kinase 1 can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK. (LocusLink)
C24846	TCF3_Gene	Transcription_Factor_Gene	TCF3 Gene|E2A|E2A Immunoglobulin Enhancer Binding Factors E12/E47 Gene|ITF1|TCF3|Transcription Factor 3 (E2A Immunoglobulin Enhancer Binding Factors E12/E47) Gene	Alternatively spliced human TCF3 Gene encodes E12 and E47 isoforms of 654-aa 68-kDa nuclear bHLH Transcription Factor 3. TCF3 is homologous to MYOD, MYC, 'daughterless', 'achaete-scute' and 'twist' families. As a heterodimer with tissue-specific bHLH proteins (e.g., ASH1 and TWIST2), TCF3 determines diverse cell fates during embryogenesis. TCF3 heterodimers bind DNA on CANNTG E-box motifs, such as kappa Ig gene enhancer E2 sites. TCF3 is likely phosphorylated following NGF stimulation. Crucial in dimerization and DNA binding, the bHLH motif forms 2 amphipathic helices that contain highly conserved hydrophobic residues. TCF3 is involved in B-ALL through a t(1;19)(q23;p13.3) translocation and fusion with PBX1. (NCI)
C24847	TCF7L2_Gene	Transcription_Factor_Gene	TCF7L2 Gene|TCF-4|TCF4|TCF7L2|Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) Gene	Member of the high mobility group (HMG) family of DNA-binding proteins; activates transcription when complexed with beta-catenin (CTNNB1); contains an HMG box DNA-binding domain. (LocusLink)
C24848	TCL1B_Gene	Gene_with_Unknown_or_Unclassified_Function	TCL1B Gene|T-Cell Leukemia/Lymphoma 1B Gene|TCL1B|TML1	Related to TCL1A oncogene, a gene involved in the development of T-cell leukemia. (from OMIM)
C24849	TCTA_Gene	Gene_with_Unknown_or_Unclassified_Function	TCTA Gene|T-Cell Leukemia Translocation Altered Gene|TCTA	Ubiquitously expressed (highest in kidney), human TCTA Gene encodes 103-aa 11-kDa T-Cell Leukemia Translocation Altered Gene Product. (NCI)
C24850	TEC_Gene	Non-Receptor_Tyrosine_Kinase_Gene	TEC Gene|PSCTK4|TEC|Tec Protein Tyrosine Kinase Gene	The protein encoded by this gene belongs to the Tec family, which is a subfamily of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome.(LocusLink)
C24851	TEK_Gene	Receptor_Tyrosine_Kinase_Gene	TEK Gene|TEK|TEK Tyrosine Kinase, Endothelial (Venous Malformations, Multiple Cutaneous and Mucosal) Gene|TIE-2|TIE2|VMCM|VMCM1	Expressed predominantly in endothelia and angioblasts, human TEK Gene (TIE Family) encodes TEK Tyrosine Kinase (TIE2), a type I transmembrane protein receptor, closely related to the TIE receptor, with activating ligand ANG-1 and inhibitory ligand ANG-2. With a unique extracellular domain containing 2 Ig-like C2 domains separated by 3 EGF-like domains connected to 3 FN III-like domains, the ANG1/ANG2 receptor TEK is important in angiogenesis, endothelial cell proliferation and differentiation, and endothelial cell patterning during vascular morphogenesis. TEK may constitute a mammalian endothelial cell lineage marker. Activating defects and deficiencies in TEK are associated with venous malformations (VMCM). (NCI)
C24852	TFAP2C_Gene	Transcription_Factor_Gene	TFAP2C Gene|AP2-Gamma|ERF1|TFAP2C|Transcription Factor AP-2 Gamma (Activating Enhancer Binding Protein 2 Gamma) Gene	Similar in structure to TFAP2A, 10-kb human TFAP2C Gene (AP-2 Family) at 20q13.2 contains 7 exons that encode 450-aa 49-kD AP-2 Gamma, a sequence-specific dimeric transcription co-activator that binds to 5prime-GCCNNNGGC-3prime DNA sequence in cellular enhancers of many genes involved in retinoic acid-induced neuroectodermal differentiation. The promoter contains no canonical TATA and CCAAT boxes, but has CpG islands and binding sites for OCT1 and AP2. Exon 1 is untranslated. AP-2 Gamma also suppresses expression of the C/EBP-Alpha, MCAM/MUC18, and c-MYC genes. Unlike the N-terminal activation domain, the C-terminal DNA-binding and dimerization domains of AP-2- Gamma are highly conserved with other family members. AP2-B may form homodimers or heterodimers with AP-2 family members. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C24853	TFDP2_Gene	Transcription_Factor_Gene	TFDP2 Gene|DP2|Dp-2|TFDP2|Transcription Factor Dp-2 (E2F Dimerization Partner 2) Gene	Expressed in heart, skeletal muscle, placenta, kidney, brain, lung, and liver by human TFDP2 Gene (E2F/DP Family), alternative isoforms alpha (446-aa, 49-kDa), beta (369-aa, 43-kDa), gamma (370-aa), and delta (385-aa, 48-kDa) of phosphorylated nuclear Transcription Factor Dp-2, in a heterodimeric complex with E2F family members, regulate genes required for G1/S cell cycle progression, S-phase progression, cell cycle regulation, DNA replication, or apoptosis. TFDP2 binds DNA cooperatively with E2F through the E2 recognition site, TTTCC/GCGC. Interact of DP/E2F with hypophosphorylated RB1, P107, and P130 inhibits the E2F transactivation domain. In mid-to-late G1, phosphorylated RB detaches from DP/E2F rendering E2F transcriptionally active. Viral oncoproteins E1A, T-antigen, and HPV E7 can sequester RB protein, releasing active DP/E2F complex. (NCI)
C24854	TFE3_Gene	Transcription_Factor_Gene	TFE3 Gene|TFE3|Transcription Factor Binding to IGHM Enhancer 3 Gene	Ubiquitously expressed 7-exon human TFE3 Gene (bHLH Family) encodes 743-aa 80-kDa nuclear Transcription Factor Binding to IGHM Enhancer 3, which contains an activation domain, leucine zipper, and bHLH domain and binds to the Ig heavy-chain enchancer MUE3 motif and to the USF/MLTF site. Efficient DNA binding requires dimerization with another bHLH protein. TFE3 is involved in papillary renal cell carcinoma through chromosomal translocations t(X;1)(p11.2;q21.2) which involves PRCC; t(X;1)(p11.2;p34) which involves PSF, and Inv(X)(p11.2;q12) which involves NONO.  (NCI)
C24855	TGFA_Gene	Growth_Factor_Gene	TGFA Gene|TGFA|Transforming Growth Factor, Alpha Gene	Transforming growth factors (TGFs) are biologically active polypeptides that reversibly confer the transformed phenotype on cultured cells. Alpha-TGF shows about 40% sequence homology with epidermal growth factor and competes with EGF for binding to the EGF receptor, stimulating its phosphorylation and producing a mitogenic response (OMIM)
C24856	TGFB1_Gene	Transforming_Growth_Factor-Beta_Family_Gene	TGFB1 Gene|CED|DPD1|TGFB|TGFB1|Transforming Growth Factor, Beta 1 (Camurati-Engelmann Disease) Gene	The TGFB1 gene at 19q13.1 encodes Transforming Growth Factor Beta 1 (TGF-Beta 1), which is a member of the TGF-beta family. This secreted multifunctional peptide controls proliferation, differentiation, and other functions in many cell types. Many cells synthesize TGF-Beta 1 and essentially all of them have specific receptors for this peptide. TGF-Beta 1 regulates the actions of many other peptide growth factors and determines a positive or negative direction of their effects. (from Swiss-Prot)
C24857	TGFB2_Gene	Transforming_Growth_Factor-Beta_Family_Gene	TGFB2 Gene|G-TSF|TGFB2|Transforming Growth Factor, Beta 2 Gene	The TGFB2 gene encodes TGF-beta 2, which is a disulfide-linked homodimer belonging to the TGF-beta cytokine family that has suppressive effects on Interleukin-2-dependent T-cell growth. It may have an autocrine function in enhancing tumor growth and/or reducing immunosurveillance of tumor development. Two isoforms are produced by alternative splicing. TGF-beta 2 is expressed in a wide variety of mesenchymal tissues and in the ventral nervous system during human embryogenesis. (from OMIM 190220, Swiss-Prot P08112, and NCI)
C24858	TGFBI_Gene	Gene_with_Unknown_or_Unclassified_Function	TGFBI Gene|BIGH3|CDB1|CDGG1|CSD|CSD1|CSD2|CSD3|LCD1|TGFBI|Transforming Growth Factor, Beta 1 (Camurati-Engelmann Disease) Gene	Constitutively expressed in many tissues (high in corneal epithelium) and induced by TGF-beta, human TGFBI Gene encodes highly conserved 683-aa 75-kDa (precursor) extracellular Transforming Growth Factor-Beta Induced Protein IGH3, containing an N-signal peptide, four 140-aa FAS1 domains with internal homology, and a C-RGD motif. RGD is found in many extracellular matrix proteins that modulate cell adhesion and serves as a ligand recognition sequence for several integrins. With similar structure to fasciclin I (putative neuronal cell adhesion protein) and OSF-2 (potential bone adhesion protein), TGFBI binds to types I, II, and IV collagens. A potential adhesion protein, TGFBI may play role in cell-collagen interactions, may be associated with microfibrils and the cell surface, and may be involved in endochondral bone formation. TGFBI defects cause CDGG1, CDRB, CDL1, CDL3A, and ACD. (NCI)
C24859	TGFBR1_Gene	Receptor_Serine-Threonine_Kinase_Gene	TGFBR1 Gene|ACVRLK4|ALK-5|TGFBR1|Transforming Growth Factor, Beta Receptor I (Activin A Receptor Type II-Like Kinase, 53kDa) Gene	Expressed in all tissues (most in placenta), 9-exon 31-kb human TGFBR1 Gene (TGFBR Ser/Thr Family) encodes 503-aa 53-kDa (56-kDa precursor) Transforming Growth Factor Beta Receptor I, a type I transmembrane protein receptor for multifunctional cytokine TGFB1 containing a signal peptide, an extracellular Cys-rich region with an N-glycosylation site, a transmembrane region, and a cytoplasmic protein Ser/Thr kinase domain that mediates induction of cell-matrix adhesion genes and regulates cell cycle progression. TGF-beta binds either TGFBR1 or transmembrane Ser/Thr TGF-Beta II receptor, which form an active heterodimeric complex. TGFB stimulation leads to phosphorylation and activation of SMAD2 and SMAD3, which, complexed with SMAD4, accumulate in the nucleus and regulate transcription of target genes. Continuous SMAD nucleocytoplasmic shuttling during TGFB signaling monitors receptor activity. (NCI)
C24860	TGFBR3_Gene	Receptor_Serine-Threonine_Kinase_Gene	TGFBR3 Gene|ALK-5|TGFBR3|Transforming Growth Factor, Beta Receptor III (Betaglycan, 300kDa) Gene	Human TGFBR3 Gene encodes 849-aa 93-kDa (precursor) Transforming Growth Factor Beta Receptor III, a membrane-bound or soluble glycoprotein heavily modified by glycosaminoglycan groups, with regions of similarity to endoglin, and containing a ZP domain. Lacking a recognizable signaling domain, TGFBR3 binds to TGF-Beta and may be a TGFBR and FGFR receptor accessory molecule; it may capture and retain TGF-Beta for presentation to signaling receptors. TGF-beta is a multifunctional cytokine that modulates cell differentiation, cell cycle progression, cellular migration, adhesion, and extracellular matrix production. TGFBR3 can also bind inhibin and function as coreceptor with ActRII; inhibin forms crosslinked complexes with TGFBR3 and ActRII. TGFBR3 also binds beta arrestin 2, which appears to trigger cytoplasmic phosphorylation by TGFBR2. (NCI)
C24861	TIE_Gene	Receptor_Tyrosine_Kinase_Gene	TIE1 Gene|JTK14|TIE|TIE Gene|TIE1|Tyrosine Kinase with Immunoglobulin-Like and EGF-Like Domains 1 Gene	Specifically expressed in developing endothelial cells, human TIE Gene (TIE Tyr Kinase Family) encodes 1138-aa 125-kDa (precursor) type I transmembrane Protein Receptor Tyrosine Kinase TIE 1, containing 2 Ig-like C2-type domains, 3 fibronectin type III domains, and 3 EGF-like domains. TIE1 receptor may be involved in multiple protein-protein interactions, possibly including endothelial cell adhesion, blood clotting, and inflammation. TIE1 receptor is important in angiogenesis, particularly endothelial vascular formation. Combinatorial ANG-1 and TIE1 orphan receptor function is critical for right-side venous system development. (NCI)
C24862	TLR1_Gene	Toll-Like_Receptor_Family_Gene	TLR1 Gene|DKFZp547I0610|DKFZp564I0682|KIAA0012|TIL|TLR1|Toll-Like Receptor 1 Gene|rsc786	Ubiquitously expressed (highest in spleen, ovary, leukocytes, thymus, and small intestine) human TLR1 Gene (TLR family) encodes 786-aa 90-kDa (precursor) type I transmembrane Toll-Like Receptor 1, containing a TIR domain and 8 LRR repeats and having a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR1 binds to the TLR2 extracellular domain and cooperates with TLR2. TLR1 appears to bind MyD88 via their TIR domains, and to TRAF6, leading to NF-Kappa-B activation, cytokine secretion, and inflammatory response. (NCI)
C24863	TLR2_Gene	Toll-Like_Receptor_Family_Gene	TLR2 Gene|TIL4|TLR2|Toll-Like Receptor 2 Gene|Toll/Interleukin 1 Receptor-Like 4 Gene	Highly expressed in monocytes, bone marrow, lymph node, and spleen, human TLR2 Gene (TLR Family) encodes 784-aa 90-kDa (precursor) type I transmembrane Toll-Like Receptor 2, containing a TIR domain and 14 LRR repeats and having a fundamental role in pathogen recognition and activation of innate immunity. Sharing structural and functional similarities, TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production for effective immunity. With LY96, TLR2 mediates response to microbial lipoproteins and cell wall components. Binding LY96 and TLR6 via the extracellular domains, TLR2 recognizes MALP-2, STF, PSM, and OspA-L with TLR6. TLR2 acts via MyD88 (via their TIR domains) and TRAF6, activating NF-Kappa-B, cytokine secretion, and inflammatory response. TLR2 may promote apoptosis in response to lipoproteins. (NCI)
C24864	TLR3_Gene	Toll-Like_Receptor_Family_Gene	TLR3 Gene|TLR3|Toll-Like Receptor 3 Gene	Expressed most in placenta, pancreas, and CD11c+ immature dendritic leukocytes, human TLR3 Gene (TLR Family) encodes 904-aa 104-kDa (precursor) type I membrane protein Toll-Like Receptor 3, containing a TIR domain and 22 LRR repeats. Likely involved in host viral defense, TLR3 recognizes viral dsRNA and has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR3 appears to act via MyD88 (TIR interaction) and TRAF6, leading to NF-Kappa-B activation and production of type I interferons. (NCI)
C24865	TLR4_Gene	Toll-Like_Receptor_Family_Gene	TLR4 Gene|TLR4|TOLL|Toll-Like Receptor 4 Gene|hToll	Expressed most in placenta, spleen, and myelomonocytic leukocytes, human TLR4 Gene (TLR Family) encodes isoforms A-D of 96-kDa (precursor) type I membrane protein Toll-Like Receptor 4, containing a TIR domain and 21 LRR repeats. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. As part of the LPS receptor (with CD14 and LY96), TLR4 mediates the immune response to LPS in gram-negative bacteria. Binding to LY96 via the extracellular domain and to MyD88 and TIRAP via their TIR domains, TLR4 acts via MyD88, TIRAP, and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and the inflammatory response. TLR4 Asn-526 and Asn-575 glycosylation seems necessary for the LPS-response. (NCI)
C24866	TLR5_Gene	Toll-Like_Receptor_Family_Gene	TLR5 Gene|TIL3|TLR5|Toll-Like Receptor 5 Gene	Highly expressed in ovary and myelomonocytic cells, human TLR5 Gene (TLR Family) encodes 858-aa 98-kDa (precursor) type I membrane protein Toll-Like Receptor 5, containing a TIR domain and 15 LRR repeats. Mediating detection of bacterial flagellin (a virulence factor), TLR5 has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. Likely bound to MyD88 via the TIR domains, TLR5 acts via MyD88 and TRAF6, leading to NF-Kappa-B activation, TNF-alpha production, and the inflammatory response. (NCI)
C24867	TLR6_Gene	Toll-Like_Receptor_Family_Gene	TLR6 Gene|TLR6|Toll-Like Receptor 6 Gene	Expressed in monocytes, CD11c+ immature dendritic cells, and dermal endothelial cells, human TLR6 Gene (TLR Family) encodes 796-aa 92-kDa (precursor) type I membrane protein Toll-Like Receptor 6, containing a TIR domain and 13 LRR repeats. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. Bound extracellularly to TLR2, TLR6 mediates cellular response to fungi and bacterial lipoproteins MALP-2, STF, PSM, and OspA-L. TLR6 acts via MyD88 (TIR interaction) and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and the inflammatory response. (NCI)
C24868	TLR7_Gene	Toll-Like_Receptor_Family_Gene	TLR7 Gene|TLR7|Toll-Like Receptor 7 Gene	Expressed in lung, placenta, spleen, brain, stomach, small intestine, and pre-dendritic cells, human TLR7 Gene (TLR Family) encodes 104-aa 121-kDa (precursor) type I membrane protein Toll-Like Receptor 7, containing a TIR domain and 27 LRR repeats. TLR7 has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR7 likely acts via MyD88 (TIR interaction) and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. (NCI)
C24869	TLR8_Gene	Toll-Like_Receptor_Family_Gene	TLR8 Gene|TLR8|Toll-Like Receptor 8 Gene	Expressed in lung, brain, heart, liver, placenta, monocytes, peripheral leukocytes, and CD11c+ immature dendritic cells, human TLR8 Gene (TLR Family) encodes 1041-aa 120-kDa (precursor) type I membrane protein Toll-Like Receptor 8, containing a TIR domain and 24 LRR repeats. TLR8 has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR8 likely acts via MyD88 (TIR interaction) and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. (NCI)
C24870	TLX1_Gene	Retired_Concepts	TLX1 Gene|HOX11|TCL3|TLX1
C24871	TMPRSS2_Gene	Protease_Gene	TMPRSS2 Gene|Epitheliasin Gene|PRSS10|TMPRSS2|Transmembrane Protease, Serine 2 Gene	Expressed in small intestine, prostate, colon, stomach, and salivary gland, human TMPRSS2 Gene (Peptidase S1 Family) encodes 492-aa 54-kDa (precursor) Transmembrane Protease Serine 2, containing a type II transmembrane domain, an LDL-receptor class A domain, a scavenger receptor cysteine-rich (SRCR) domain, and a protease domain. The protease domain is thought to be cleaved, activated, and secreted after autocleavage. (NCI)
C24872	TNFRSF11B_Gene	TNF_Receptor_Family_Gene	TNFRSF11B Gene|MGC29565|OCIF|OPG|TNFRSF11B|TR1|Tumor Necrosis Factor Receptor Superfamily, Member 11B (Osteoprotegerin) Gene	The protein encoded by this gene is a member of the TNF-receptor superfamily. This protein is an osteoblast-secreted decoy receptor that functions as a negative regulator of bone resorption. This protein specifically binds to its ligand, osteoprotegerin ligand (TNFSF11/OPGL), both of which are key extracellular regulators of osteoclast development. Studies of the mouse counterpart also suggest this protein and its ligand play a role in lymph-node organogenesis and vascular calcification. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined. (LocusLink)
C24873	TNFRSF6B_Gene	TNF_Receptor_Family_Gene	TNFRSF6B Gene|DCR3|DJ583P15.1.1|DKFZP434C013|KIAA1088|M68|NHL|TNFRSF6B|TR6|Tumor Necrosis Factor Receptor Superfamily, Member 6B, Decoy Gene|bK3184A7.3	This gene has multiple transcript variants but the full length nature of some variants has not been determined. The encoded isoforms a, b, and c are related to RAD3/ERCC2, a plasma membrane Ras-related GTPase. The amplification or overexpression of these isoforms is thought to contribute to cell growth and tumor progression. It is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. (LocusLink)
C24874	TNFSF11_Gene	Tumor_Necrosis_Factor_Family_Gene	TNFSF11 Gene|ODF|OPGL|RANKL|TNFSF11|TRANCE|Tumor Necrosis Factor (Ligand) Superfamily, Member 11 Gene|hRANKL2|sOdf	This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. The gene product was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. Two alternatively spliced transcript variants have been found. (LocusLink)
C24875	TNK1_Gene	Non-Receptor_Tyrosine_Kinase_Gene	TNK1 Gene|TNK1|Tyrosine Kinase, Non-Receptor, 1 Gene	Expressed as a 3-kb transcript in prostate, testis, ovary, small intestine, and colon, human TNK1 Gene encodes 666-aa 72-kDa Non-Receptor Tyrosine Kinase 1, containing a putative N-terminal phosphotyrosine-binding domain, a tyrosine kinase domain, a putative SH3 domain, and a Pro-rich C-terminus containing SH3-binding motifs. The kinase domain includes an ATP-binding site and many conserved tyrosine kinase features. TNK1 shares highest homology with ACK, especially in the kinase and putative SH3 domains. Like SRC and JAK family kinases, TNK1 mediates intracellular signaling downstream of receptor activation. (NCI)
C24876	TOLLIP_Gene	Adaptor_Signaling_Protein_Gene	TOLLIP Gene|TOLLIP|Toll Interacting Protein Gene	Human TOLLIP Gene encodes 274-aa 30-kDa oligomeric Toll-Interacting Protein, containing a CUE domain, involved in IL-1 and Toll-like receptor signaling pathways. TOLLIP binds to TLR2 and TLR4/MD2 complex via its C-terminus. Complexed with Ser/Thr kinase IRAK in unstimulated cells, TOLLIP inhibits IRAK phosphorylation and kinase activity. Upon IL-1 signaling, TOLLIP interacts with the IL-1RacP TIR domain in the activated receptor complex (IL-1RI/IL-1RacP/MyD88), recruiting IRAK to the complex. MyD88 triggers IRAK1 autophosphorylation and IRAK1 dissociation. (NCI)
C24877	TPD52_Gene	Gene_with_Unknown_or_Unclassified_Function	TPD52 Gene|D52|N8L|TPD52|Tumor Protein D52 Gene|hD52	Expressed as a 3.3-kb transcript in several tissues, human TPD52 Gene (TPD52 Family) encodes 184-aa 20-kDa Tumor Protein D52 with a potential glycosylation site, several potential phosphorylation sites, and homology to N-type calcium channels. TPD52 forms homodimers, or heterodimers with other family members; D52, D53, and D54 share homology, including a coiled-coil domain indicative of protein-protein interactions. D52 may be involved in calcium-mediated signal transduction and cell proliferation. (NCI)
C24878	TPD52L1_Gene	Gene_with_Unknown_or_Unclassified_Function	TPD52L1 Gene|D53|TPD52L1	Expressed as a 1.5-kb transcript in kidney and skin, human TPD52L1 Gene (TPD52 Family) encodes 204-aa 22-kDa Tumor Protein D52-Like 1, with 52% identity to D52, a coiled-coil domain, and PEST domains. D52, D53, and D54 share significant homology, including a coiled-coil domain indicative of protein-protein interactions. TPD52L1 forms homodimers, or heterodimers with other family members. Like D52, TPD52L1 may be involved in calcium-mediated signal transduction and cell proliferation. (NCI)
C24879	TRPM5_Gene	Gene_with_Unknown_or_Unclassified_Function	TRPM5 Gene|LTRPC5|MTR1|TRPM5|Transient Receptor Potential Cation Channel, Subfamily M, Member 5 Gene	Expressed as a 4.5-kb transcript in various tissues, human TRPM5 Gene encodes Transient Receptor Potential Cation Channel Subfamily M Member 5, related to the transient receptor potential (trp) protein TRPC1 and potentially involved in regulation of cellular Ca(2+) influx. The putative open reading frame encodes alternative 872-aa or 1,165-aa proteins, each with several predicted membrane-spanning domains. Mouse Trpm5 functions as a cationic channel that is gated when internal calcium stores are depleted. (NCI)
C24880	TRRAP_Gene	Transcription_Coactivator_Gene	TRRAP Gene|PAF400|TR-AP|TRRAP|Transformation/Transcription Domain-Associated Protein Gene	Human TRRAP Gene (TRA1 Kinase Family) encodes 3859-aa 438-kDa and 3830-aa isoforms of adapter protein Transformation/Transcription Domain-Associated Protein, containing 2 TPR repeats and a component of multiprotein chromatin PCAF histone acetylase complex, TFTC-HAT complex, STAGA complex, and TIP60 HAT and BAF53 complexes, which acetylate histone H4/H2A in nucleosomes. Required for p53-, E2F1- and E2F4-mediated transcription activation, TRRAP interacts with GCN5L2, TP53, MYC, E2F1, and E2F4 transcription factors; it probably links E1A, MYC, and E2F1 to HAT complexes allowing transcription activation. Lacking kinase catalytic motifs and activity, the PI3K/PI4K domain is required for recruitment of HAT complexes and MYC-dependent transactivation. Cell cycle TRRAP is probably not required in transcription activation following histone acetylation. (NCI)
C24881	TSHR_Gene	G_Protein-Coupled_Receptor_Gene	TSHR Gene|TSHR|Thyroid Stimulating Hormone Receptor Gene	Human TSHR Gene (FSH/LSH/TSH GPCR1 Family) encodes alternative long and short isoforms of integral membrane protein Thyroid Stimulating Hormone Receptor, a Thyrotropin receptor containing 6 LRR repeats whose activity is mediated by adenylate cyclase-activating G proteins and controls thyroid cell metabolism. TSHR also acts as a thyrostimulin receptor (GPA2+GPB5). TSHR defects cause hypothyroidism, Graves' disease, euthyroidism or papillary and follicular thyroid neoplasms. (NCI)
C24882	TSKS_Gene	Gene_with_Unknown_or_Unclassified_Function	TSKS Gene|TSKS|TSKS1|Testis-Specific Kinase Substrate Gene	This gene may play a role in testicular physiology, spermatogenesis or spermiogenesis. Expression of the encoded protein is highest in the testis and down-regulated in testicular cancer. The gene is localized to the region 19q13.3 among the related RAS viral oncogene homolog (RRAS) and interferon regulatory factor 3 (IRF3) genes, which are both involved in tumorigenesis pathways and progression. (LocusLink)
C24883	TSLP_Gene	Cytokine_Gene	TSLP Gene|TSLP|Thymic Stromal Lymphopoietin Gene	This gene encodes a hemopoietic cytokine proposed to signal through a heterodimeric receptor complex composed of the thymic stromal lymphopoietin receptor and the IL-7R alpha chain. It mainly impacts myeloid cells and induces the release of T cell-attracting chemokines from monocytes and enhances the maturation of CD11c(+) dendritic cells. Alternative splicing of this gene results in two transcript variants. (LocusLink)
C24884	TSPY_Gene	Gene_with_Unknown_or_Unclassified_Function	TSPY1 Gene|DYS14|TSPY|TSPY1|Testis Specific Protein, Y-Linked 1 Gene|pJA923	Likely up-regulated by androgen and expressed in spermatogonia and spermatocytes, human TSPY Gene encodes 308-aa 35-kDa phosphorylated cytoplasmic Testis-Specific Y-Encoded Protein that may be involved in sperm differentiation and proliferation. (NCI)
C24885	TTC4_Gene	Gene_with_Unknown_or_Unclassified_Function	TTC4 Gene|TTC4|Tetratricopeptide Repeat Domain 4 Gene	This gene was identified as being in a region in which loss of heterozygosity has been frequently observed in breast cancers.  The protein includes 4 rpeats of the 34-amino acid tetratricopeptide repeat (TPR) motif, found in a variety of proteins and may mediate protein-protein or protein-membrane interactions. (from LocusLink and OMIM)
C24886	TTK_Gene	Cell_Cycle_Gene	TTK Gene|ESK|MPS1L1|PYT|TTK|TTK Protein Kinase Gene	Expressed as a 4-kb mRNA in proliferating cells, human TTK Gene (Ser/Thr Kinase Family) encodes 841-aa 95-kDa TTK Protein Kinase, a likely dual-specificity kinase since it phosphorylates proteins on tyrosine as well as serine and threonine. TTK is probably associated with kinetochore or centrosome function in cell proliferation. Kinetochore-associated Mps1 kinase (Xenopus) is necessary to establish and maintain the mitotic checkpoint. Required for kinetochore recruitment and retention of active CENPE, Mps1 is necessary for Mad1 and Mad2 kinetochore association and inhibition of the Anaphase-Promoting Complex/Cyclosome. Mps1 (mouse), a Cdk2 substrate, regulates centrosome duplication jointly with Cdk2. By regulating Mps1 S phase stability, Cdk2 promotes centrosome duplication by Mps1. (NCI)
C24887	CXCR6_Gene	Chemokine_Receptor_Gene	CXCR6 Gene|BONZO|CXCR6|Chemokine (C-X-C Motif) Receptor 6 Gene|STRL33|TYMSTR	In response to CXCL16 CXCR6 probably functions in interactions between dendritic cells and T cells and in regulating T-cell migration in the splenic red pulp. (from OMIM)
C24888	TYRO3_Gene	Receptor_Tyrosine_Kinase_Gene	TYRO3 Gene|RSE|TYRO3	Widely expressed (abundant in brain), human TYRO3 Gene (AXL/UFO Tyr Kinase Family) encodes 890-aa 97-kDa (precursor) type I membrane protein TYRO3 Protein Tyrosine Kinase, a putative receptor tyrosine kinase that may be involved in cell adhesion in the central nervous system and contains 2 Ig-like C2-type domains and 2 fibronectin type III domains. (NCI)
C24889	TYROBP_Gene	Ligand_Binding_Protein_Gene	TYROBP Gene|DAP12|KARAP|PLO-SL|PLOSL|TYRO Protein Tyrosine Kinase Binding Protein Gene|TYROBP	Human TYROBP Gene encodes 113-aa 12-kDa (precursor) disulfide-linked homodimeric Tyr-phosphorylated TYRO Protein Tyrosine Kinase Binding Protein, a type I transmembrane polypeptide containing a cytoplasmic ITAM motif that may act as an activating signal transduction element in bone modeling, brain myelination, and inflammation. TYROBP associates with KIR family membrane glycoproteins without a cytoplasmic ITIM; KIR/TYROBP complexes promote cellular activation. TYROBP interacts with SIRPB1 and may bind TCR zeta chain-associated ZAP-70 kinase and SYK tyrosine kinase. (NCI)
C24890	UBE2D2_Gene	Ubiquitin_Ligase_Gene	UBE2D2 Gene|UBC4|UBCH5B|UBE2D2|Ubiquitin-Conjugating Enzyme E2D 2 (UBC4/5 Homolog, Yeast) Gene	Human UBE2D2 Gene (E2 Ubiquitin-Conjugating Enzyme Family) encodes 147-aa 16.7-kDa Ubiquitin-Conjugating Enzyme E2D 2, which targets selective degradation of short-lived and abnormal proteins, such as E6/E6-AP-induced p53 ubiquitination, through covalent attachment of ubiquitin, the second step of ubiquitin conjugation. UBE2D2 interacts with the SCF/E3 ubiquitin ligase complex. Ubiquitination involves E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. (NCI)
C24891	UNC13_Gene	Signaling_Pathway_Gene	UNC13B Gene|MUNC13|UNC-13 Homolog B (C. Elegans) Gene|UNC13|UNC13 Gene|UNC13B|hmunc13	Human UNC13 Gene encodes 1591-aa UNC-13 Homolog B, containing 3 C2 domains, a C1 DAG-binding domain, and highly conserved N- and C-terminal similarity to rat Munc13 homologues. UNC13 is a putative DAG receptor and may act in a PKC-independent DAG-activated apoptosis pathway. UNC13 also appears to be a presynaptic protein that promotes synaptic vesicle priming by acting through syntaxin. Post-docking synaptic vesicle exocytosis priming requires SNARE complex formation. The default closed syntaxin configuration is incompatible with SNARE formation; the N-terminus binds the SNARE motif and occludes SNARE protein interactions. UNC13 binding to the syntaxin N-terminus may promote an open syntaxin configuration and prime synaptic vesicles for fusion. (NCI)
C24892	USP6_Gene	Protease_Gene	USP6 Gene|Proto-Oncogene TRE-2|TRE-2 Gene|USP6|Ubiquitin Specific Protease 6 (Tre-2 Oncogene) Gene|Ubiquitin Specific Protease 6 Gene	Some evidence suggests that the human Ubiquitin Specific Protease 6 Gene locus (C19 Peptidase Family) at 17q11 may be part of three discontinuous elements originating 5-prime to 3-prime on chromosomes 5, 18, and 17. RNA transcripts are detected in a variety of cancer cells regardless of tissue origin, but not in normal cells. An 8 kb transcript possesses a long noncoding region and a translatable region with two open reading frames. The 5-prime ORF encodes a 786-amino acid hydrophilic protein with two charge clusters, suggesting nucleic acid-binding properties. Ubiquitin Specific Protease 6 appears to have ATP-independent isopeptidase activity, cleaving at the carboxyl terminus of ubiquitin.  (Omim, Swiss-Prot, LocusLink and NCI)
C24893	USP8_Gene	Protease_Gene	USP8 Gene|HUMORF8 Gene|HumORF8|KIAA0055|UBPY|USP8|Ubiquitin Specific Protease 8 Gene	Related to TRE2 oncogene, human Ubiquitin Specific Protease 8 Gene (C19 Peptidase Family) at 15q15.2 encodes Ubiquitin Specific Protease 8, a deubiquitinating enzyme that cleaves at the carboxyl terminus of ubiquitin. In chronic myeloproliferative disorder, an oncogenic fusion of the 5-prime end of p85-beta occurs with the 3-prime end of USP8.  (Omim, Swiss-Prot, LocusLink, and NCI)
C24894	VAV3_Gene	VAV_Family_Gene	VAV3 Gene|VAV 3 Oncogene Gene|VAV3	Human VAV3 Oncogene (VAV Family) at 1p13.2 encodes an 847-amino acid VAV-3 Protein with similarity to VAV1 and VAV2 and exhibits variable expression of a 5 kb transcript in peripheral blood lymphocytes, spleen, brain, thymus, heart, kidney, liver, placenta, and lung. Alpha and beta isoforms are produced by alternative splicing. VAV3 contains DBL and pleckstrin homology domains, a calponin homology region, an acidic motif, a DAG binding domain, two SH3 regions, and a SH2 domain. Protein encoded by splice variant VAV3.1 contains only the C-terminal SH3-SH2-SH3 region. Regulating the actin cytoskeleton and transcription, VAV3 acts as a GEF on RHOA, RHOG, and RAC1. VAV1, VAV2, and VAV3 respond to similar cell surface receptor tyrosine kinases. VAV3 is rapidly phosphorylated on TCR or EGFR activation. VAV1 and VAV3 enhance NFKB-dependent transcription. Integrin-induced phosphorylation requires SYK.  (Omim, Swiss-Prot, LocusLink, and NCI)
C24895	_10p11_1	Chromosome_Band	10p11.1	A chromosome band present on 10p
C24896	_10p11_23	Chromosome_Band	10p11.23	A chromosome band present on 10p
C24897	_10p12	Chromosome_Band	10p12	A chromosome band present on 10p
C24898	_10p12_3-p11_2	Chromosome_Band	10p12.3-p11.2	A chromosome band present on 10p
C24899	_10p12_31	Chromosome_Band	10p12.31	A chromosome band present on 10p
C24900	_10q11_1	Chromosome_Band	10q11.1	A chromosome band present on 10q
C24901	_10q11_21	Chromosome_Band	10q11.21	A chromosome band present on 10q
C24902	_10q24-q25	Chromosome_Band	10q24-q25	A chromosome band present on 10q
C24903	_10q24-qter	Chromosome_Band	10q24-qter	A chromosome band present on 10q
C24904	_10q24_31	Chromosome_Band	10q24.31	A chromosome band present on 10q
C24905	_10q25	Chromosome_Band	10q25	A chromosome band present on 10q
C24906	_10q25_1	Chromosome_Band	10q25.1	A chromosome band present on 10q
C24907	_10q25_3	Chromosome_Band	10q25.3	A chromosome band present on 10q
C24908	_10q25_3-q26_1	Chromosome_Band	10q25.3-q26.1	A chromosome band present on 10q
C24909	_10q26_13	Chromosome_Band	10q26.13	A chromosome band present on 10q
C24910	_10q26_13-q26_3	Chromosome_Band	10q26.13-q26.3	A chromosome band present on 10q
C24911	_11p11_2-p11_1	Chromosome_Band	11p11.2-p11.1	A chromosome band present on 11p
C24912	_11p12	Chromosome_Band	11p12	A chromosome band present on 11p
C24913	_11p12-p11_2	Chromosome_Band	11p12-p11.2	A chromosome band present on 11p
C24914	_11p13-p12	Chromosome_Band	11p13-p12	A chromosome band present on 11p
C24915	_11p14_3	Chromosome_Band	11p14.3	A chromosome band present on 11p
C24916	_11p15_2	Chromosome_Band	11p15.2	A chromosome band present on 11p
C24917	_11p15_5-p15_4	Chromosome_Band	11p15.5-p15.4	A chromosome band present on 11p
C24918	_11q12_2	Chromosome_Band	11q12.2	A chromosome band present on 11q
C24919	_11q13_2	Chromosome_Band	11q13.2	A chromosome band present on 11q
C24920	_11q13_3-q13_5	Chromosome_Band	11q13.3-q13.5	A chromosome band present on 11q
C24921	_11q13_4	Chromosome_Band	11q13.4	A chromosome band present on 11q
C24922	_11q14_2	Chromosome_Band	11q14.2	A chromosome band present on 11q
C24923	_11q14_2-q14_3	Chromosome_Band	11q14.2-q14.3	A chromosome band present on 11q
C24924	_11q23-q24	Chromosome_Band	11q23-q24	A chromosome band present on 11q
C24925	_11q24-q24	Chromosome_Band	11q24-q24	A chromosome band present on 11q
C24926	_12p11_2	Chromosome_Band	12p11.2	A chromosome band present on 12p
C24927	_12p12_1-p11_2	Chromosome_Band	12p12.1-p11.2	A chromosome band present on 12p
C24928	_12p13-p12_3	Chromosome_Band	12p13-p12.3	A chromosome band present on 12p
C24929	_12p13_1-p12_3	Chromosome_Band	12p13.1-p12.3	A chromosome band present on 12p
C24930	_12q12	Chromosome_Band	12q12	A chromosome band present on 12q
C24931	_12q12-q14	Chromosome_Band	12q12-q14	A chromosome band present on 12q
C24932	_12q13-q15	Chromosome_Band	12q13-q15	A chromosome band present on 12q
C24933	_12q13_13	Chromosome_Band	12q13.13	A chromosome band present on 12q
C24934	_12q14-q15	Chromosome_Band	12q14-q15	A chromosome band present on 12q
C24935	_12q21	Chromosome_Band	12q21	A chromosome band present on 12q
C24936	_12q23-q24	Chromosome_Band	12q23-q24	A chromosome band present on 12q
C24937	_12q23-q24_1	Chromosome_Band	12q23-q24.1	A chromosome band present on 12q
C24938	_12q24_1	Chromosome_Band	12q24.1	A chromosome band present on 12q
C24939	_12q24_11	Chromosome_Band	12q24.11	A chromosome band present on 12q
C24940	_12q24_13	Chromosome_Band	12q24.13	A chromosome band present on 12q
C24941	_12q24_31	Chromosome_Band	12q24.31	A chromosome band present on 12q
C24942	_13q11-q12	Chromosome_Band	13q11-q12	A chromosome band present on 13q
C24943	_13q12-13	Chromosome_Band	13q12-13	A chromosome band present on 13q
C24944	_13q14_1	Chromosome_Band	13q14.1	A chromosome band present on 13q
C24945	_13q14_12-q14_2	Chromosome_Band	13q14.12-q14.2	A chromosome band present on 13q
C24946	_13q34	Chromosome_Band	13q34	A chromosome band present on 13q
C24947	_14q13_1	Chromosome_Band	14q13.1	A chromosome band present on 14q
C24948	_14q22	Chromosome_Band	14q22	A chromosome band present on 14q
C24949	_14q23-q24_1	Chromosome_Band	14q23-q24.1	A chromosome band present on 14q
C24950	_14q31-q32_1	Chromosome_Band	14q31-q32.1	A chromosome band present on 14q
C24951	_14q32_1	Chromosome_Band	14q32.1	A chromosome band present on 14q
C24952	_14q32_1-q32_2	Chromosome_Band	14q32.1-q32.2	A chromosome band present on 14q
C24953	_14q32_33	Chromosome_Band	14q32.33	A chromosome band present on 14q
C24955	_15q14	Chromosome_Band	15q14	A chromosome band present on 15q
C24956	_15q15_1-q21_1	Chromosome_Band	15q15.1-q21.1	A chromosome band present on 15q
C24957	_15q21	Chromosome_Band	15q21	A chromosome band present on 15q
C24958	_15q22	Chromosome_Band	15q22	A chromosome band present on 15q
C24959	_15q22_3-q23	Chromosome_Band	15q22.3-q23	A chromosome band present on 15q
C24960	_15q23	Chromosome_Band	15q23	A chromosome band present on 15q
C24961	_15q25	Chromosome_Band	15q25	A chromosome band present on 15q
C24962	_16p11_2-12_1	Chromosome_Band	16p11.2-12.1	A chromosome band present on 16p
C24963	_16p11_2-p11_1	Chromosome_Band	16p11.2-p11.1	A chromosome band present on 16p
C24964	_16q12_2	Chromosome_Band	16q12.2	A chromosome band present on 16q
C24965	_16q22_2-q22_3	Chromosome_Band	16q22.2-q22.3	A chromosome band present on 16q
C24966	_16q24	Chromosome_Band	16q24	A chromosome band present on 16q
C24968	_17p11_1	Chromosome_Band	17p11.1	A chromosome band present on 17p
C24969	_17p11_2	Chromosome_Band	17p11.2	A chromosome band present on 17p
C24970	_17p13	Chromosome_Band	17p13	A chromosome band present on 17p
C24971	_17q11-qter	Chromosome_Band	17q11-qter	A chromosome band present on 17q
C24972	_17q11_1	Chromosome_Band	17q11.1	A chromosome band present on 17q
C24973	_17q12-q21	Chromosome_Band	17q12-q21	A chromosome band present on 17q
C24974	_17q21-q22	Chromosome_Band	17q21-q22	A chromosome band present on 17q
C24975	_17q21_1-q21_3	Chromosome_Band	17q21.1-q21.3	A chromosome band present on 17q
C24976	_17q22-q23_2	Chromosome_Band	17q22-q23.2	A chromosome band present on 17q
C24977	_17q22-qter	Chromosome_Band	17q22-qter	A chromosome band present on 17q
C24978	_17q24-q25	Chromosome_Band	17q24-q25	A chromosome band present on 17q
C24979	_17q25_1	Chromosome_Band	17q25.1	A chromosome band present on 17q
C24980	_17q25_3	Chromosome_Band	17q25.3	A chromosome band present on 17q
C24981	_18q11_1	Chromosome_Band	18q11.1	A chromosome band present on 18q
C24982	_18q12-q21	Chromosome_Band	18q12-q21	A chromosome band present on 18q
C24983	_18q21_31	Chromosome_Band	18q21.31	A chromosome band present on 18q
C24984	_19p13_1-13_2	Chromosome_Band	19p13.1-13.2	A chromosome band present on 19p
C24985	_19q13_1-qter	Chromosome_Band	19q13.1-qter	A chromosome band present on 19q
C24986	_19q13_4	Chromosome_Band	19q13.4	A chromosome band present on 19q
C24987	_19q13_41	Chromosome_Band	19q13.41	A chromosome band present on 19q
C24988	_19q13_42	Chromosome_Band	19q13.42	A chromosome band present on 19q
C24989	_1p13_2	Chromosome_Band	1p13.2	A chromosome band present on 1p
C24990	_1p13_3-p13_1	Chromosome_Band	1p13.3-p13.1	A chromosome band present on 1p
C24991	_1p21	Chromosome_Band	1p21	A chromosome band present on 1p
C24992	_1p31_2-p31_1	Chromosome_Band	1p31.2-p31.1	A chromosome band present on 1p
C24993	_1p31_3	Chromosome_Band	1p31.3	A chromosome band present on 1p
C24994	_1p32_3	Chromosome_Band	1p32.3	A chromosome band present on 1p
C24995	_1p32_3-p31_3	Chromosome_Band	1p32.3-p31.3	A chromosome band present on 1p
C24996	_1p33	Chromosome_Band	1p33	A chromosome band present on 1p
C24997	_1p33-p32	Chromosome_Band	1p33-p32	A chromosome band present on 1p
C24998	_1p33-p34	Chromosome_Band	1p33-p34	A chromosome band present on 1p
C24999	_1p34-p33	Chromosome_Band	1p34-p33	A chromosome band present on 1p
C25000	_1p34_1	Chromosome_Band	1p34.1	A chromosome band present on 1p
C25001	_1p35-p34_2	Chromosome_Band	1p35-p34.2	A chromosome band present on 1p
C25002	_1p35_3	Chromosome_Band	1p35.3	A chromosome band present on 1p
C25003	_1p36_1-p35	Chromosome_Band	1p36.1-p35	A chromosome band present on 1p
C25004	_1p36_12	Chromosome_Band	1p36.12	A chromosome band present on 1p
C25005	_1p36_2-p36_12	Chromosome_Band	1p36.2-p36.12	A chromosome band present on 1p
C25006	_1p36_33	Chromosome_Band	1p36.33	A chromosome band present on 1p
C25007	_1pter-p22_1	Chromosome_Band	1pter-p22.1	A chromosome band present on 1p
C25008	_1q12-q23	Chromosome_Band	1q12-q23	A chromosome band present on 1q
C25009	_1q23_2	Chromosome_Band	1q23.2	A chromosome band present on 1q
C25010	_1q25-q31_1	Chromosome_Band	1q25-q31.1	A chromosome band present on 1q
C25011	_1q31	Chromosome_Band	1q31	A chromosome band present on 1q
C25012	_1q31-q32	Chromosome_Band	1q31-q32	A chromosome band present on 1q
C25013	_1q32_1	Chromosome_Band	1q32.1	A chromosome band present on 1q
C25014	_1q41-q42	Chromosome_Band	1q41-q42	A chromosome band present on 1q
C25015	_1q42_1-q42_2	Chromosome_Band	1q42.1-q42.2	A chromosome band present on 1q
C25016	_20p11	Chromosome_Band	20p11	A chromosome band present on 20p
C25017	_20p11_2	Chromosome_Band	20p11.2	A chromosome band present on 20p
C25018	_20p13	Chromosome_Band	20p13	A chromosome band present on 20p
C25019	_20q11_1-11_23	Chromosome_Band	20q11.1-11.23	A chromosome band present on 20q
C25020	_20q13_1-q13_2	Chromosome_Band	20q13.1-q13.2	A chromosome band present on 20q
C25021	_21q22_11	Chromosome_Band	21q22.11	A chromosome band present on 21q
C25022	_22q11_22	Chromosome_Band	22q11.22	A chromosome band present on 22q
C25023	_22q13_2	Chromosome_Band	22q13.2	A chromosome band present on 22q
C25024	_22q13_33	Chromosome_Band	22q13.33	A chromosome band present on 22q
C25025	_2p13	Chromosome_Band	2p13	A chromosome band present on 2p
C25026	_2p14_1	Chromosome_Band	2p14.1	A chromosome band present on 2p
C25027	_2p23_3-p23_2	Chromosome_Band	2p23.3-p23.2	A chromosome band present on 2p
C25028	_2p24	Chromosome_Band	2p24	A chromosome band present on 2p
C25029	_2p24_3-q21_3	Chromosome_Band	2p24.3-q21.3	A chromosome band present on 2p
C25030	_2q11_2-q12	Chromosome_Band	2q11.2-q12	A chromosome band present on 2q
C25031	_2q12	Chromosome_Band	2q12	A chromosome band present on 2q
C25032	_2q12-q14	Chromosome_Band	2q12-q14	A chromosome band present on 2q
C25033	_2q12_2	Chromosome_Band	2q12.2	A chromosome band present on 2q
C25034	_2q14_1	Chromosome_Band	2q14.1	A chromosome band present on 2q
C25035	_2q22-q24	Chromosome_Band	2q22-q24	A chromosome band present on 2q
C25036	_2q22_2-q23_3	Chromosome_Band	2q22.2-q23.3	A chromosome band present on 2q
C25037	_2q23-q24	Chromosome_Band	2q23-q24	A chromosome band present on 2q
C25038	_2q32_2	Chromosome_Band	2q32.2	A chromosome band present on 2q
C25039	_2q35-q37	Chromosome_Band	2q35-q37	A chromosome band present on 2q
C25040	_2q36	Chromosome_Band	2q36	A chromosome band present on 2q
C25041	_2q36-q37	Chromosome_Band	2q36-q37	A chromosome band present on 2q
C25042	_2q36_3	Chromosome_Band	2q36.3	A chromosome band present on 2q
C25043	_2q37_1	Chromosome_Band	2q37.1	A chromosome band present on 2q
C25044	_3p12-q13_2	Chromosome_Band	3p12-q13.2	A chromosome band present on 3p
C25045	_3p14_1	Chromosome_Band	3p14.1	A chromosome band present on 3p
C25046	_3p24	Chromosome_Band	3p24	A chromosome band present on 3p
C25047	_3p26-p24	Chromosome_Band	3p26-p24	A chromosome band present on 3p
C25048	_3q21-q23	Chromosome_Band	3q21-q23	A chromosome band present on 3q
C25049	_3q21-qter	Chromosome_Band	3q21-qter	A chromosome band present on 3q
C25050	_3q22	Chromosome_Band	3q22	A chromosome band present on 3q
C25051	_3q23	Chromosome_Band	3q23	A chromosome band present on 3q
C25052	_3q24	Chromosome_Band	3q24	A chromosome band present on 3q
C25053	_3q25_1-q25_2	Chromosome_Band	3q25.1-q25.2	A chromosome band present on 3q
C25054	_3q26_1-q26_2	Chromosome_Band	3q26.1-q26.2	A chromosome band present on 3q
C25055	_3q28	Chromosome_Band	3q28	A chromosome band present on 3q
C25056	_3q29	Chromosome_Band	3q29	A chromosome band present on 3q
C25057	_4p12	Chromosome_Band	4p12	A chromosome band present on 4p
C25058	_4p14	Chromosome_Band	4p14	A chromosome band present on 4p
C25059	_4p15_1	Chromosome_Band	4p15.1	A chromosome band present on 4p
C25060	_4p16_1	Chromosome_Band	4p16.1	A chromosome band present on 4p
C25061	_4q11	Chromosome_Band	4q11	A chromosome band present on 4q
C25062	_4q13_1-q21_1	Chromosome_Band	4q13.1-q21.1	A chromosome band present on 4q
C25063	_4q13_3	Chromosome_Band	4q13.3	A chromosome band present on 4q
C25064	_4q21_1	Chromosome_Band	4q21.1	A chromosome band present on 4q
C25065	_4q21_3	Chromosome_Band	4q21.3	A chromosome band present on 4q
C25066	_4q22_1-q23	Chromosome_Band	4q22.1-q23	A chromosome band present on 4q
C25067	_4q26-q27	Chromosome_Band	4q26-q27	A chromosome band present on 4q
C25068	_4q28-q32	Chromosome_Band	4q28-q32	A chromosome band present on 4q
C25069	_4q32	Chromosome_Band	4q32	A chromosome band present on 4q
C25070	_4q34_1-q35_1	Chromosome_Band	4q34.1-q35.1	A chromosome band present on 4q
C25071	_4q35	Chromosome_Band	4q35	A chromosome band present on 4q
C25072	_5p13	Chromosome_Band	5p13	A chromosome band present on 5p
C25073	_5p13-p12	Chromosome_Band	5p13-p12	A chromosome band present on 5p
C25074	_5p13_1	Chromosome_Band	5p13.1	A chromosome band present on 5p
C25075	_5q11	Chromosome_Band	5q11	A chromosome band present on 5q
C25076	_5q11_2	Chromosome_Band	5q11.2	A chromosome band present on 5q
C25077	_5q12_1-q13_2	Chromosome_Band	5q12.1-q13.2	A chromosome band present on 5q
C25078	_5q12_3	Chromosome_Band	5q12.3	A chromosome band present on 5q
C25079	_5q21_3	Chromosome_Band	5q21.3	A chromosome band present on 5q
C25080	_5q23-q33	Chromosome_Band	5q23-q33	A chromosome band present on 5q
C25081	_5q23_2	Chromosome_Band	5q23.2	A chromosome band present on 5q
C25082	_5q31-q32	Chromosome_Band	5q31-q32	A chromosome band present on 5q
C25083	_5q31_1-q33_1	Chromosome_Band	5q31.1-q33.1	A chromosome band present on 5q
C25084	_5q31_3	Chromosome_Band	5q31.3	A chromosome band present on 5q
C25085	_5q33_1-qter	Chromosome_Band	5q33.1-qter	A chromosome band present on 5q
C25086	_5q34	Chromosome_Band	5q34	A chromosome band present on 5q
C25087	_5q34-q35	Chromosome_Band	5q34-q35	A chromosome band present on 5q
C25088	_5q35_2	Chromosome_Band	5q35.2	A chromosome band present on 5q
C25089	_6p21_1-p12_2	Chromosome_Band	6p21.1-p12.2	A chromosome band present on 6p
C25090	_6p21_3-p21_2	Chromosome_Band	6p21.3-p21.2	A chromosome band present on 6p
C25091	_6p22	Chromosome_Band	6p22	A chromosome band present on 6p
C25092	_6p23	Chromosome_Band	6p23	A chromosome band present on 6p
C25093	_6q12	Chromosome_Band	6q12	A chromosome band present on 6q
C25094	_6q13-q21	Chromosome_Band	6q13-q21	A chromosome band present on 6q
C25095	_6q16_1-q16_3	Chromosome_Band	6q16.1-q16.3	A chromosome band present on 6q
C25096	_6q21-q22_1	Chromosome_Band	6q21-q22.1	A chromosome band present on 6q
C25097	_6q21-q22_3	Chromosome_Band	6q21-q22.3	A chromosome band present on 6q
C25098	_6q21-qter	Chromosome_Band	6q21-qter	A chromosome band present on 6q
C25099	_6q22_33	Chromosome_Band	6q22.33	A chromosome band present on 6q
C25100	_6q24	Chromosome_Band	6q24	A chromosome band present on 6q
C25101	_6q24-q25_1	Chromosome_Band	6q24-q25.1	A chromosome band present on 6q
C25102	_6q26	Chromosome_Band	6q26	A chromosome band present on 6q
C25103	_7p11	Chromosome_Band	7p11	A chromosome band present on 7p
C25104	_7p12_1	Chromosome_Band	7p12.1	A chromosome band present on 7p
C25105	_7p13-p12	Chromosome_Band	7p13-p12	A chromosome band present on 7p
C25106	_7p14_1	Chromosome_Band	7p14.1	A chromosome band present on 7p
C25107	_7p15-p13	Chromosome_Band	7p15-p13	A chromosome band present on 7p
C25108	_7p21	Chromosome_Band	7p21	A chromosome band present on 7p
C25109	_7p21-p15	Chromosome_Band	7p21-p15	A chromosome band present on 7p
C25110	_7p22-p21	Chromosome_Band	7p22-p21	A chromosome band present on 7p
C25111	_7q11_23	Chromosome_Band	7q11.23	A chromosome band present on 7q
C25112	_7q21_11	Chromosome_Band	7q21.11	A chromosome band present on 7q
C25113	_7q32_3	Chromosome_Band	7q32.3	A chromosome band present on 7q
C25114	_7q33-q34	Chromosome_Band	7q33-q34	A chromosome band present on 7q
C25115	_7q34-q35	Chromosome_Band	7q34-q35	A chromosome band present on 7q
C25116	_7q36	Chromosome_Band	7q36	A chromosome band present on 7q
C25117	_8p11_21	Chromosome_Band	8p11.21	A chromosome band present on 8p
C25118	_8p21-p11_2	Chromosome_Band	8p21-p11.2	A chromosome band present on 8p
C25119	_8p21_1	Chromosome_Band	8p21.1	A chromosome band present on 8p
C25120	_8p23_2-p23_1	Chromosome_Band	8p23.2-p23.1	A chromosome band present on 8p
C25121	_8q21_3-q22	Chromosome_Band	8q21.3-q22	A chromosome band present on 8q
C25122	_8q22_3-q23_1	Chromosome_Band	8q22.3-q23.1	A chromosome band present on 8q
C25123	_8q24-qter	Chromosome_Band	8q24-qter	A chromosome band present on 8q
C25124	_9p12-p11	Chromosome_Band	9p12-p11	A chromosome band present on 9p
C25125	_9p13	Chromosome_Band	9p13	A chromosome band present on 9p
C25126	_9p21-p12	Chromosome_Band	9p21-p12	A chromosome band present on 9p
C25127	_9p21_2	Chromosome_Band	9p21.2	A chromosome band present on 9p
C25128	_9p22	Chromosome_Band	9p22	A chromosome band present on 9p
C25129	_9p24	Chromosome_Band	9p24	A chromosome band present on 9p
C25130	_9q22	Chromosome_Band	9q22	A chromosome band present on 9q
C25131	_9q22_1	Chromosome_Band	9q22.1	A chromosome band present on 9q
C25132	_9q31_3-q32	Chromosome_Band	9q31.3-q32	A chromosome band present on 9q
C25133	_9q32-q33	Chromosome_Band	9q32-q33	A chromosome band present on 9q
C25134	_9q33-q34	Chromosome_Band	9q33-q34	A chromosome band present on 9q
C25135	_9q33-q34_1	Chromosome_Band	9q33-q34.1	A chromosome band present on 9q
C25136	_9q34_13	Chromosome_Band	9q34.13	A chromosome band present on 9q
C25137	Xp11_3-p11_23	Chromosome_Band	Xp11.3-p11.23	A chromosome band present on Xp
C25138	Xp22	Chromosome_Band	Xp22	A chromosome band present on Xp
C25139	Xp22_3	Chromosome_Band	Xp22.3	A chromosome band present on Xp
C25140	Xq13_1-q13_3	Chromosome_Band	Xq13.1-q13.3	A chromosome band present on Xq
C25141	Xq21_33-q23	Chromosome_Band	Xq21.33-q23	A chromosome band present on Xq
C25142	Xq22	Chromosome_Band	Xq22	A chromosome band present on Xq
C25143	Xq22-24	Chromosome_Band	Xq22-24	A chromosome band present on Xq
C25144	Xq22_3	Chromosome_Band	Xq22.3	A chromosome band present on Xq
C25145	Xq25-q26	Chromosome_Band	Xq25-q26	A chromosome band present on Xq
C25146	Xq27_1-q27_2	Chromosome_Band	Xq27.1-q27.2	A chromosome band present on Xq
C25147	Yp11_1-q11_1	Chromosome_Band	Yp11.1-q11.1	A chromosome band present on Yp
C25150	Age	Personal_Attribute	Age	How long something has existed; elapsed time since birth.
C25152	Appetite	Organismal_Process	Appetite|APT	Appetite is a natural recurring desire for food. (On-line Medical Dictionary)
C25153	Autopsy	Procedure	Autopsy|A	Autopsy is a postmortem examination of the body that includes an examination of the internal organs and structures after dissection to determine the cause of death and the nature of pathological changes.
C25154	Axis	Conceptual_Entities	Axis|AX	A straight line through a body or figure that satisfies certain conditions.
C25155	Birth	Personal_Attribute	Birth	The event of being born.
C25157	Body_Surface_Area	Personal_Attribute	Body Surface Area|BSA	A measure of the 2-dimensional extent of the body surface (i.e., the skin).  Body surface area (BSA) can be calculated by mathematical formula or from a chart that relates height to weight.  BSA is often an important factor in dosing. (NCI)
C25158	Capsule	Solid_Dosage_Form	Capsule Dosage Form|CAP|CAPS|CAPSULE|Capsule|Capsule Dose Form	A solid dosage form in which the drug is enclosed within either a hard or soft soluble container or "shell" made from a suitable form of gelatin.
C25159	Carcinoembryonic_Antigen	Cell_Adhesion_Molecule	Carcinoembryonic Antigen|CEA	A cancer-specific antigen associated with both tumors and the developing fetus. The main use of this antigen is as a tumor marker, especially with respect to intestinal cancers. Production of the antigen ceases shortly before birth, but may reappear in people who develop certain types of cancer.
C25160	City	Geographic_Area	City	A large and densely populated urban area; a city specified in an address.
C25161	Classification	Conceptual_Entities	Classification|CLASS	A method of generalization, the systematic arrangement of entities into classes or groups based on mutual similarity and certain differing characteristics.
C25162	Code	Conceptual_Entities	Code|CD|Coding System	A system, often of numbered categories, for representation of data.
C25163	Coombs_Test	Immunologic_Techniques	Coombs Test|Coomb's	A Coombs test is performed to detect the presence of antibodies against red blood cells.  It can either be indirect, measuring the presence of antibodies to red blood cells in the blood, or direct, measuring the presence of antibodies on the surface of red blood cells.
C25164	Date	Temporal_Modifier	Date|DT	The particular day, month and year an event has happened or will happen.
C25165	Daughter	Relative	Daughter	A female human offspring.
C25166	Discharge_from_Healthcare_Facility	Healthcare_Activity	Discharge from Healthcare Facility|DC|Discharge|Patient Discharge	In healthcare, discharge represents the end point of an inpatient hospital contact which consists of one or several days of care. (from Wikipedia)
C25167	Distance	Properties_or_Attributes	Distance|DIS	The space separating two objects or points.
C25168	Donor	Person	Tissue Donor|DON|Donor	Someone who gives blood or tissue or an organ to be used in another person.
C25169	Route	Conceptual_Entities	Route|RTE	A way of getting from one place to another; an established line of travel or access; the way a chemical or pollutant enters an organism after contact, particularly, the way of drug administration.
C25170	E-mail	Telecommunications	E-mail|EMAIL|Electronic Mail|Email	E-mail is short for "electronic mail" and refers to composing, sending, and receiving messages over electronic communication systems. Most e-mail systems use the Internet.
C25171	Eligibility_Determination	Healthcare_Activity	Eligibility Determination|ELIG|Eligibility|Protocol Screening	The act of determining if a subject is suitable for enrollment in a study according specific protocol criteria and procedures.
C25172	Employment	Personal_Attribute	Employment|EMPL	The occupation for which you are paid.
C25173	Family	Social_Concepts	Family|FAM	A domestic group, or a number of domestic groups linked through descent (demonstrated or stipulated) from a common ancestor, marriage, or adoption.
C25174	Father	Relative	Father	A male parent.
C25175	Filed	Conceptual_Entities	Filed	Having been placed in a file; recorded in a public office or in a court of law.
C25176	Projection	Conceptual_Entities	Projection|Projected	A prediction made by extrapolating from past observations.
C25177	Genitalia	Other_Anatomic_Concept	Genitalia|GENIT	The external sex organs.
C25178	Health	Conceptual_Entities	Health|HLTH	Health refers to a person's state of physical, mental and social well-being; usually it refers specifically to the state of being in good health, a state of complete physical, mental and social well-being, and does not consist only of the absence of disease or infirmity. In any organism health constitutes a form of homeostasis with inputs and outputs of energy and mass in approximate equilibrium allowing for growth and continued survival. In humans, a subjective feeling of well-being coming from somatic and cognative perceptions is considered an essential component of health.
C25179	Hospitalization	Healthcare_Activity	Hospitalization|HOSP	The condition of being treated as a patient in a hospital.
C25180	Indicator	Conceptual_Entities	Indicator|Ind	An event, entity or condition that typically characterizes a prescribed environment or situation.
C25181	Industry	Technology	Industry|IND	The people or companies engaged in a particular kind of commercial enterprise; the organized action of making of goods and services for sale.
C25182	Inpatient	Person	Inpatient|INPT	A patient who is residing in the hospital where he is being treated.
C25184	Lactate_Dehydrogenase	Oxidoreductase	Lactate Dehydrogenase|EC 1.1.1.27|L-(+)-Lactate Dehydrogenase|L-Lactic Acid Dehydrogenase|LDH|Lactic Acid Dehydrogenase|NAD-Lactate Dehydrogenase	A family of homotetrameric cytoplasmic enzymes involved in the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. In vertebrates, genes for three different subunits (LDH-A, LDH-B and LDH-C) exist.
C25185	Laterality	Properties_or_Attributes	Laterality	Dominant use or manifestations of one side of the body versus the other; an indication or right versus left.
C25186	High_Density_Lipoprotein	Lipoprotein	High Density Lipoprotein|HDL	High density lipoproteins are the smallest and densest lipoproteins, and contain a high proportion of protein. They are synthesized in the liver as empty proteins and they pick up cholesterol and increase in size as they circulate through the bloodstream.  Because HDL can remove cholesterol from the arteries, and transport it back to the liver for excretion, they are seen as "good" lipoproteins. (from Wikipedia)
C25187	Low_Density_Lipoprotein	Lipoprotein	Low Density Lipoprotein|LDL	Low-density lipoprotein (LDL) is a lipoprotein that carries cholesterol around the body, for use by various cells.  LDL transports cholesterol to the arteries and increased levels are associated with atherosclerosis, and thus myocardial infarctions and strokes. This is why cholesterol inside LDL lipoproteins is called bad cholesterol. (from Wikipedia)
C25188	Marital_Status	Personal_Attribute	Marital Status|MAR-ST	A demographic parameter indicating a person's conjugal status.  Marital status categories include married, divorced, widowed, or never married. (NCI)
C25189	Mother	Relative	Mother	A female parent.
C25190	Person	Social_Concepts	Person|IND|INDS|Individual|Individuals	A single human being.
C25191	Name	Personal_Attribute	Person Name|Name|Name of Person	A word or group of words indicating the identity of a person usually consisting of a first (personal) name and a last (family) name with an optional middle name.  In some cultural traditions the family name comes first.
C25193	Occupation	Occupation_or_Discipline	Occupation|Job|Jobs|OCC	The principal activity that a person does to earn money.
C25194	Compliance	Retired_Concepts	Compliance	Acting in accordance to certain accepted standards.
C25195	Pressure	Physical_Phenomena_or_Properties	Pressure|P	The force applied to a unit area of surface.
C25196	Randomization	Clinical_or_Research_Activity	Randomization|RNDM	The allocation of individuals to groups, e.g., for experimental and control regimens, by chance. (On-line Medical Dictionary)
C25197	Recommendation	Conceptual_Entities	Recommendation|REC	Advice telling someone what the best thing to do is.
C25198	Record	Document_Type	Record|RCD|Records	Anything (e.g., a document) providing permanent evidence of or information about past events.
C25199	Role	Social_Concepts	Social Role|Role	The action or activity assigned to or required or expected of a person or group.
C25200	Self	General_Modifier	Self	The individual as the object of his own reflective consciousness.
C25201	Sensitivity	Conceptual_Entities	Sensitivity|SNTVTY	Sensitivity; the ability to respond to physical stimuli or to register small physical amounts or differences.
C25202	SGOT-AST_Protein	Transaminase	SGOT (AST)|AST	Activity measured as a test of liver function, 46/47-kDa homodimeric human Aspartate Aminotransferases (Class-I Pyridoxal-Phosphate-Dependent Aminotransferase Family) are pyridoxal phosphate-dependent enzymes involved in amino acid metabolism and in the urea and tricarboxylic acid cycles. (NCI)
C25203	Shoulder	Body_Region	Shoulder	The region of the body between the neck and the upper arm.
C25204	Sibling	Relative	Sibling|SIBS|Siblings	A person's brother or sister.
C25205	Son	Relative	Son	A male human offspring.
C25206	Temperature	Conceptual_Entities	Temperature|T	The property of a body or region of space that determines whether or not there will be a net flow of heat into it or out of it from a neighboring body or region and in which direction (if any) the heat will flow, perceptible by living organism as a somatic sensation of cold or heat. It is a measure of the average translational kinetic energy associated with the disordered microscopic motion of atoms and molecules. Temperature is measured in one of the three standard temperature scales: Celsius, Kelvin, and Fahrenheit.
C25207	Time	Temporal_Modifier	Time|Point in Time|TM|Time Point	The continuum of experience in which events pass from the future through the present to the past; a specific point in this continuum or the interval separating two points.
C25208	Weight	Characteristics	Weight|WT	The vertical force exerted by a mass as a result of gravity.
C25209	Measure	Properties_or_Attributes	Measurement|MSR|MSRMT|Measure|Measurements	Measurement is the determination of the size or magnitude of something.  It is also used ro refer to the result of this act.
C25210	Fax	Telecommunications	Fax|FX	Fax is short for facsimile, a telecommunications technology used to transfer copies of documents using devices operating over the telephone network.  It is used to refer both to the activity and the resulting document.
C25211	Schedule	Document_Type	Schedule|SCHED	A schedule is an ordered list of times at which things are planned to occur.
C25212	End_Point	Biomarker	End Point|ENPT|Endpoint|Endpoints	An endpoint is a place of termination or completion. In a clinical trial this may be a primary or secondary outcome variable used to judge the effectiveness of a treatment.
C25213	Baseline	Conceptual_Entities	Baseline|BSL	A starting point to which things may be compared.
C25214	Evaluation	Healthcare_Activity	Evaluation|EVAL	Systematic, objective appraisal of the significance, effectiveness, and impact of activities or condition according to specified objectives and criteria.
C25215	Karyotype	Miscellaneous_Molecular_Biology_Terms	Karyotype|KTYP	The appearance of the chromosomal makeup of a somatic cell in an individual or species, including the number and arrangement and size and structure of the chromosomes.
C25216	Collimator	Medical_Device	Collimator|Collimation	A diaphragm or system of diaphragms made of an absorbing material, designed to define and restrict the dimensions and direction of a beam of radiation.
C25217	Assessed	Clinical_or_Research_Activity	Assessed|ASSESS	Having determined the value, significance, or extent of.
C25218	Procedure	Intervention	Procedure|PROC	A particular course of action intended to achieve a result.
C25219	Fixation	Histological_Techniques	Fixation	The chemical preservation of a substance to maintain structural and/or molecular features of that substance as they exist in the living entity.
C25220	Sternotomy	Surgical_Incision|Thoracic_Surgical_Procedures	Sternotomy|STRNTY	Incision into or through the sternum.
C25221	Tomogram	Medical_Image	Tomogram|TOMO	A radiograph obtained by tomography.
C25222	Bronchial	Anatomy_Modifier	Bronchial	Of, or pertaining to, the bronchus.
C25223	Pleural	Anatomy_Modifier	Pleural|PLRL	Of or pertaining to the pleura.
C25224	Rectal	Anatomy_Modifier	Rectal|RTL|rectal	By or having to do with the rectum.  The rectum is the last 6 inches of the large intestine and ends at the anus.
C25225	Renal	Anatomy_Modifier	Renal	Of or pertaining to the kidney.
C25226	Mesenteric	Anatomy_Modifier	Mesenteric|MESTRC	Of, or relating to, or located in a mesentery.
C25227	High	General_Modifier	High	Greater than normal in degree or intensity or amount.
C25228	Right	General_Modifier	Right|RT	Being or located on or directed toward the side of the body to the east when facing north.
C25229	Left	Anatomy_Modifier	Left|LT	Being or located on or directed toward the side of the body to the west when facing north.
C25230	Lateral	Anatomy_Modifier	Lateral|LAT	Situated at or extending to the side.
C25231	Anterior	Anatomy_Modifier	Anterior|ANT	Denoting the front surface of the body; often used to indicate the position of one structure relative to another.
C25232	Medial	Anatomy_Modifier	Medial|MED	Toward the middle or inside (as opposed to lateral).
C25233	Peripheral	Anatomy_Modifier	Peripheral|PERIPH	On or near an edge or constituting an outer boundary; the outer area.
C25234	Internal	General_Modifier	Internal|INT	Happening or arising or located within some limits, or especially, within some surface.
C25235	Superior	Anatomy_Modifier	Superior|SUPP	In anatomy indicating higher than a given reference point.
C25236	Proximal	Anatomy_Modifier	Proximal|PROX|proximal	In medicine, refers to a part of the body that is closer to the center of the body than another part. For example, the knee is proximal to the toes. The opposite is distal.
C25237	Distal	Anatomy_Modifier	Distal|DIST|distal	In medicine, refers to a part of the body that is farther away from the center of the body than another part. For example, the fingers are distal to the shoulder. The opposite is proximal.
C25238	Segmental	General_Modifier	Segmental|SEG	Having naturally dividable parts; divided into sections with each section adjacent to the other.
C25239	Superficial	Disease_Gross_Finding_Modifier	Superficial|superficial	Affecting cells on the surface.  Not invasive.
C25240	Deep	Anatomy_Modifier	Deep	Extending relatively far inward.
C25241	Horizontal	General_Modifier	Horizontal|HOR	Parallel to or in the plane of the horizon.
C25242	Longitudinal	General_Modifier	Longitudinal|LNGIT	Running lengthwise.
C25243	Vertical	General_Modifier	Vertical|VERT	Upright in position or posture.
C25244	Area	Properties_or_Attributes	Area|A	The extent of a 2-dimensional surface enclosed within a boundary.
C25245	Surface	Conceptual_Entities	Surface|SURF	The extended two-dimensional outer boundary of a three-dimensional object.
C25246	Positive	General_Modifier	Positive|POS	Involving advantage or good.
C25247	Negative	General_Modifier	Negative|NEG	Involving disadvantage or harm.
C25248	Long	Conceptual_Entities	Long	Of relatively great or greater than average spatial extension or temporal duration.
C25249	Short	General_Modifier	Short	Having little (physical) length or seeming to be limited in (temporal) duration.
C25250	Complete	General_Modifier	Complete|COMP|Completion	To possess every necessary or normal part or component or step.  It may also mean having come or been brought to a conclusion.
C25251	Primary	General_Modifier	Primary|PRM	Occurring first in time or sequence; original; of greatest rank or importance or value.
C25252	Microscopic	General_Modifier	Microscopic|MISCP|microscopic	Too small to be seen except under a microscope.
C25253	Multifocal	General_Modifier	Multifocal|MULFCL	Arising from or pertaining to many locations.
C25254	Progressive	Disease_Clinical_Modifier	Progressive|PROGS	Advancing in extent or severity.
C25255	Soft	General_Modifier	Soft	Lacking in hardness relatively or comparatively.
C25256	Quantity	General_Modifier	Quantity|AMT|Amount|QTY	The total amount or number.
C25257	Phase	Conceptual_Entities	Phase|Stage	A distinguishable part, a stage in a series of events or in a process of development, e.g. any of the varying aspects or stages in course of a disease; a fraction of a cycle.
C25258	Most	General_Modifier	Most|Greatest	Greatest in amount, extent, or degree.
C25259	Mixed	General_Modifier	Mixed	Involving or composed of different kinds.
C25260	Third	General_Modifier	Third|TRD	Following the second position in an ordering or series; coming next after the second and just before the fourth in position.
C25261	Medical	General_Modifier	Medical|MED	Relating to the study or practice of medicine.
C25262	Neurologic	Anatomy_Modifier	Neurologic|NEURO|Neurological|neurologic	Pertaining to or used in or practicing neurology..
C25263	Prognostic	General_Modifier	Prognostic|PROGN	Having value for making predictions.
C25264	Carina	Respiratory_System_Part	Carina	A ridge or ridge-like structure.  In humans it usually refers to the trachea.  The carina of trachea is part of the lowest tracheal cartilage which is placed between the orifices of the two bronchi.
C25265	Upper_GI	Retired_Concepts	Upper GI
C25266	Intestinal	Anatomy_Modifier	Intestinal|INTES|intestinal	Having to do with the intestines.
C25267	Lymphatic	Anatomy_Modifier	Lymphatic|LYMPT	Of, or relating to, or produced by lymph.
C25268	Infraclavicular_Region	Body_Region	Infraclavicular Region|IFCLV|Infraclavicular	The region below the clavicle.
C25269	Symptomatic	General_Modifier	Symptomatic|SM|symptomatic	Exhibiting the symptoms of a particular disease.
C25270	Extension	Conceptual_Entities	Extension|EX	An addition to the length of something.
C25271	Painful	General_Modifier	Painful|PN	Causing physical or psychological misery, pain or distress.
C25272	Painless	General_Modifier	Painless	Not causing physical or psychological misery, pain or distress.
C25273	Residence	Sites_of_Care_Delivery	Residence|RES	Any address at which a person dwells more than temporarily.
C25274	Actual	General_Modifier	Actual	Existing in fact; real.
C25275	Occurrence	Temporal_Modifier	Occurrence|OCURS|Occurrences	An instance of something happening, such as an event or incident.
C25276	Neural_Cell_Adhesion_Molecule	Cell_Adhesion_Molecule	Neural Cell Adhesion Molecule|CD56|CD56 Antigen|NCAM|NCAM1|NKH-1	Neural Cell Adhesion Molecule is a membrane-bound glycoprotein member of the Ig superfamily that binds to a variety of other cell adhesion proteins involved in diverse contact-mediated interactions.  NCAM appears on early embryonic cells and is important in the formation of cell collectives at sites of morphogenesis.  Later it is found on differentiated neurons, astrocytes, oligodendrocytes, and myotubes and mediates neuronal adhesion, guidance, and differentiation.  NCAM plays a role in cell-cell and cell-matrix adhesion through homophilic and heterophilic binding.  The invertebrate cell adhesion molecules fasciclin II (grasshoppers and Drosophila) and apCAM (Aplysia) are related to NCAM and can mediate homophilic cell aggregation.  Four main isoforms exist, including CD56, but many variants result from alternative splicing and post-translational modifications.  (from OMIM 116930 and NCI)
C25277	Therapeutic	General_Modifier	Therapeutic|therapeutic	Relating to or involved in therapy.
C25278	Fluid	Substance	Fluid|FL	A continuous amorphous substance that tends to flow and to conform to the outline of its container (i.e., a liquid or a gas).  Also used as an adjective to describe something with properties like that of a fluid.
C25279	Onset	Temporal_Modifier	Onset	The start, beginning, or early stages.
C25280	Recent	Temporal_Modifier	Recent|REC	Near to or not long before the present.
C25281	Associated	General_Modifier	Associated|ASSOC	Joined in some kind of relationship.
C25282	Within	General_Modifier	Within|W/I	On the inside; contained in.
C25283	Quality	General_Modifier	Quality|QUAL	An essential and distinguishing attribute of something or someone; a degree or grade of excellence or worth.
C25284	Type	Conceptual_Entities	Type|TP	Something distinguishable as an identifiable class based on common qualities.
C25285	Diameter	Properties_or_Attributes	Diameter|DIAM|diameter	The length of a straight line passing through the center of a circle or sphere and connecting two points on the circumference.
C25286	Necrotic	Disease_Morphology_Modifier	Necrotic|NECR	Relating to or affected by necrosis.
C25287	Auer_Rod	Subcellular_Structure	Auer Rod|Auer Body|Auer Rods	Rod-shaped structures of uncertain nature in the cytoplasm of immature myeloid cells, especially myeloblasts, in acute myelocytic leukemia; may be an abnormal form of lysosomes; they contain peroxidase and acid phosphatase, and stain red by azure-eosin stains. (On-line Medical Dictionary)
C25288	Hairy_Cell	Leukemic_Lymphocyte|Neoplastic_B-Lymphocyte	Hairy Cell|HC	An abnormal large leukocyte found in the blood in hairy cell leukemia; it has numerous irregular cytoplasmic villi that give it a flagellated or hairy appearance.
C25289	Brother	Relative	Brother|BRO	A male sibling.
C25290	Adopted	Personal_Attribute	Adopted|ADPT	Having been legally made a member of a family.
C25291	Venous	Anatomy_Modifier	Venous|VENS	Of, or pertaining to, or contained in, or performing the function of the veins.
C25292	Cardiovascular	Anatomy_Modifier	Cardiovascular|CV|cardiovascular	Cardiovascular; pertaining to the heart or blood vessels.
C25293	SGPT-ALT_Protein	Transaminase	SGPT (ALT)|ALT	Activity measured as a test of liver function, human Glutamic-Pyruvate Transaminases (Alanine Aminotransferase Family) are pyridoxal phosphate-dependent enzymes involved in cellular nitrogen metabolism, amino acid metabolism, and liver gluconeogenesis. Glutamic Pyruvic Transaminases mediate conversion of major intermediate metabolites, catalyzing reversible transamination between alanine and alpha-ketoglutarate to form pyruvate and glutamate. (NCI)
C25294	Test	Techniques	Lab Test|Laboratory Test|Test|laboratory test	A medical procedure that involves testing a sample of blood, urine, or other substance from the body. Tests can help determine a diagnosis, plan treatment, check to see if treatment is working, or monitor the disease over time.
C25295	Mobile	General_Modifier	Mobile|MOBL	Moving or capable of moving readily.
C25296	Birth_Date	Retired_Concepts	Birth Date|BD	The calendar date on which a person was born.
C25297	Notification	Clinical_or_Research_Activity	Notification|NOTFN	Informing by words.
C25298	Systolic_Pressure	Personal_Attribute	Systolic Pressure|SBP	The blood pressure during the contraction of the left ventricle of the heart.
C25299	Diastolic_Pressure	Personal_Attribute	Diastolic Pressure|DBP|Diastolic Blood Pressure	The blood pressure after the contraction of the heart while the chambers of the heart refill with blood.
C25300	Culture_Procedure	Procedure	Culture Procedure|CX|Culture	Any laboratory procedure for growing microorganisms.
C25301	Day	Temporal_Modifier	Day|D|Days	The time for Earth to make a complete rotation on its axis; ordinarily divided into twenty-four hours.  This also refers to a specific day.
C25302	Granulomatous	Disease_Morphology_Modifier	Granulomatous|GRNLM	Relating to or characterized by granulomas.
C25303	Multicentric	General_Modifier	Multicentric|MULCTRC	Having many centers. A multicentric cancer consists of a primary tumor with satellites of cancerous growth in surrounding tissues.
C25304	Total	General_Modifier	Total|TTL	Pertaining to an entirety or whole, also constituting the full quantity or extent; complete; derived by addition.
C25305	Examination	Procedure	Examination|Assessment|EXM|Exam|Medical Inspection	An appraisal or evaluation of a patient's condition by a physician or registered nurse, based on clinical and laboratory data, medical history, and the patient's account of symptoms.  2. The process by which a patient's condition is appraised or evaluated. (Taber's)
C25306	Side	Anatomy_Modifier	Side	One of the two lateral margins or surfaces of a body, midway between the front and back.
C25307	Contralateral	Anatomy_Modifier	Contralateral|CONL|contralateral	Having to do with the opposite side of the body.
C25308	Ipsilateral	Anatomy_Modifier	Ipsilateral|INPSLT|ipsilateral	Having to do with the same side of the body.
C25309	Lower	General_Modifier	Lower|L	The bottom one of two.
C25310	Mediastinal	Anatomy_Modifier	Mediastinal|MEDST	Related to the mediastinum.
C25311	Oral	Anatomy_Modifier	Oral|oral	By or having to do with the mouth.
C25312	Parietal	Anatomy_Modifier	Parietal	Of, or relating to, or associated with the parietal bones.
C25313	Peritoneal	Anatomy_Modifier	Peritoneal|PERTNL|peritoneal	Having to do with the peritoneum (the tissue that lines the abdominal wall and covers most of the organs in the abdomen).
C25314	Radial	Anatomy_Modifier	Radial	Arranged like rays or radii; radiating from a common center or moving in the direction of a radius; relating to or near the radius.
C25315	Visceral	Anatomy_Modifier	Visceral|VISC|visceral	Having to do with the viscera, which are the soft internal organs of the body, including the lungs, the heart, and the organs of the digestive, excretory, reproductive, and circulatory systems.
C25316	Paraaortic	Anatomy_Modifier	Paraaortic|PARAA	Regions near to the aorta.
C25317	Paratracheal	Anatomy_Modifier	Paratracheal|PARTRCL	Regions near to the trachea.
C25318	Subaortic	Anatomy_Modifier	Subaortic	Below the aorta.
C25319	Place	Conceptual_Entities	Place	The particular portion of space occupied by a physical object.
C25320	Protocol	Protocol_Generic_Term	Clinical Trial Protocol|PROT|Protocol|Protocols|protocol	An action plan for a clinical trial.  The plan states what the study will do, how, and why.  It explains how many people will be in it, who is eligible to participate, what study agents or other interventions they will be given, what tests they will receive and how often, and what information will be gathered.
C25321	Distant	Anatomy_Modifier	Distant|DIS	Far apart in space, time, or relevance.
C25322	Long-Term	Temporal_Modifier	Long-Term|LT	Involving or being in effect for a long time.
C25323	Nodal	Anatomy_Modifier	Nodal	Of or pertaining to a node, any bulge or swelling of an anatomical structure or part.
C25324	Viable	General_Modifier	Viable|VIBL	Capable of life or normal growth and development.
C25325	Slide	Diagnostic_Therapeutic_and_Research_Equipment	Slide	A flat rectangular piece of glass on which specimens can be mounted for microscopic study.
C25326	Whole	General_Modifier	Whole|WH	Including all components without exception; being one unit or constituting the full amount or extent or duration; complete.
C25327	Core	General_Modifier	Core	The center of an object; indispensable
C25328	Unrelated	General_Modifier	Unrelated|UNRLA	Not connected or associated e.g. by kinship.
C25329	Supraclavicular	Anatomy_Modifier	Supraclavicular	Positioned above the clavicle.
C25330	Duration	Properties_or_Attributes	Duration|DUR	The period of time during which something continues.
C25331	Progression	Conceptual_Entities	Progression|PROG	Process of disease spreading and/or increase of its severity; also, in mathematics: regular or proportional advance in increase or decrease of numbers; continued proportion (arithmetical, geometrical, or harmonic).
C25332	Extent	Conceptual_Entities	Extent|EXT	The range, magnitude, or distance over which a thing spans an interval of distance, space, or time.
C25333	Depth	Characteristics	Depth	The extent downward or inward.  The perpendicular measurement from the surface downward to determine deepness.
C25334	Length	Characteristics	Length|L	The linear extent in space from one end of something to the other end, or the extent of something from beginning to end.
C25335	Volume	Characteristics	Volume|VOL	The amount of three dimensional space occupied by an object or the capacity of a space or container.
C25336	Pattern	Conceptual_Entities	Pattern|PATT	A distinctive style or form of something, the characteristic set of traits or actions or qualities of a group, person, or thing, as behavior patterns; in molecular biology: a nucleic acid or protein motif that is computationally detectable within aligned sequences.
C25337	Number	Properties_or_Attributes	Number|NUM|NUMS|Numbers	A numeral or string of numerals expressing value, quantity, or identification.
C25338	Score	Properties_or_Attributes	Score|SC	A number or range of numeric values measuring performance, function, quality, or ability.
C25339	Position	Conceptual_Entities	Position|POS	The particular portion of space occupied by a physical object.
C25340	Use	Properties_or_Attributes	Use|Usage	The purpose for or application or employment of something for functional or beneficial purposes.
C25341	Location	Properties_or_Attributes	Location|LCTN|LCTNS|Locations	A position, site, or point in space where something can be found.
C25342	Abdominal	Anatomy_Modifier	Abdominal|ABD|abdominal	Having to do with the abdomen, which is the part of the body between the chest and the hips that contains the pancreas, stomach, intestines, liver, gallbladder, and other organs.
C25343	Mechanism	Conceptual_Entities	Mechanism|MECH	The means by which an effect is obtained.
C25344	Paraesophageal	Anatomy_Modifier	Paraesophageal|PARES	Body regions near to the esophagus.  (NCI)
C25345	Width	Characteristics	Width|Wideness	The extent or measurement of something from side to side.
C25346	Class	Properties_or_Attributes	Class	A grouping of things based on shared common attributes.
C25347	Height	Characteristics	Height|HT	The vertical measurement or distance from the base to the top of an object; the vertical dimension of extension.
C25348	Musculoskeletal	Anatomy_Modifier	Musculoskeletal|MSC|musculoskeletal	Having to do with muscles, bones, and cartilage.
C25349	Polypectomy	Excision	Polypectomy|PLYPCMY	Surgical removal of a polyp.
C25350	Genitourinary	Anatomy_Modifier	Genitourinary|GU	Of or related to the genital and urinary organs or their functions.
C25351	Reconstruction	Surgical_Procedure	Reconstruction|RCNSTCT|reconstructive surgery	Surgery that is done to reshape or rebuild (reconstruct) a part of the body changed by previous surgery.
C25352	International_Normalized_Ratio	Conceptual_Entities	International Normalized Ratio|INR	A system, commonly called the INR, established by the World Health Organization (WHO) and the International Committee on Thrombosis and Hemostasis for reporting the results of blood coagulation (clotting) tests. All results are standardized using the international sensitivity index (ISI) for the particular thromboplastin reagent and instrument combination utilized to perform the test; the ratio of a patient's clotting time to the lab's mean reference value is normalized against the ISI. (from medterms.com and medicine.ucsf.edu)
C25353	Inferior	Anatomy_Modifier	Inferior|INF	In anatomy indicating lower than a given reference point.
C25354	Academic_Degree	Award	Academic Degree|DEG|Degree	An academic degree is an award conferred by a college, university, or other postsecondary education institution as official recognition for the successful completion of a program of studies.
C25355	Upper	General_Modifier	Upper|U	Higher in place or position; the topmost one of two.
C25356	Documented	General_Modifier	Documented|DOC	Furnished with or supported by documents and documentation.
C25357	Registrar	Miscellaneous_Occupations	Registrar|REG	Someone responsible for keeping records.
C25358	Attribution	Conceptual_Entities	Attribution|ATTR	Assigning to a cause or source.
C25359	Expectancy	Conceptual_Entities	Expectancy|EXPC|Expectation	Something expected, especially value (e.g. an amount, or length of time) or probability of occurrence for a specific event expected on the basis of statistical calculations.
C25360	Mutant	General_Modifier	Mutant|MUT	An altered form of an individual, organism, population, or genetic character that differs from the corresponding wild type due to one or more alterations (mutations).
C25361	Performance	Conceptual_Entities	Performance|PERF	A manner of functioning or operating.
C25362	Success	Conceptual_Entities	Success	An event that accomplishes its intended purpose.
C25363	Neural	Anatomy_Modifier	Neural|neural	Having to do with nerves or the nervous system, including the brain and the spinal cord.
C25364	Identifier	Document_Type	Identifier|Descriptor|Designation|Designator|ID	One or more characters used to identify, name, or characterize the nature, properties, or contents of a thing.
C25365	Description	Conceptual_Entities	Description|DESC|Desc	A statement or an account describing something. (Bartleby.com)
C25366	Closure	Properties_or_Attributes	Closure|CL	Closure refers to the closing of a study to further enrollment.
C25367	Assessment	Conceptual_Entities	Assessment|ASSESS	The final result of a determination of the value, significance, or extent of.
C25368	Member	Person	Member|MEM	One of the persons who compose a social group, especially an individual who has joined and participates in a group organization.
C25369	Agreement	Properties_or_Attributes	Agreement|AGR	The act of agreeing to a plan, protocol, or arrangement. Also used to describe a harmony of opinion. (NCI)
C25370	Exclusion	Conceptual_Entities	Exclusion|EXCL	The act of restricting entrance or barring from participation.
C25371	Payment	Insurance_and_Payment_Issues	Payment|PYMT	A sum of money paid.
C25372	Category	Conceptual_Entities	Category|CAT	This term is used informally to mean a class of things.
C25373	Classified	Conceptual_Entities	Classified|CLASS	Arranged in classes or categories.
C25374	Options	Conceptual_Entities	Options|OPT	Alternative choices or actions.
C25375	Report	Document_Type	Report|REP	A short textual account.
C25376	Small	General_Modifier	Small|SM	Limited in number or quantity or magnitude or extent.
C25377	Appearance	Characteristics	Appearance|APR	The outward or visible aspect of a person or thing.
C25378	Partial	General_Modifier	Partial|PRTL	Being or affecting only a part of something.
C25379	Course	Conceptual_Entities	Course|CRSE|Cycle	Passage through time; duration; a systematic or/and orderly succession; a sequence, e.g. course of treatment; a mode of action or behavior; natural development, typical manner of proceeding.
C25380	End_Date	Retired_Concepts	End Date|END-DT	The calendar date on which an activity is terminated or completed.
C25381	Maiden_Name	Name	Maiden Name|Maiden	A woman's surname before marriage.
C25382	Administered	General_Modifier	Administered|ADM	The act of having given something (e.g., a medication or test).
C25383	Begin_Date	Retired_Concepts	Start Date|BEG-DT|Begin Date	The calendar date on which something is to start or did start.
C25384	TNM	Staging_System	TNM|TNM staging system	A system for describing the extent of cancer in a patient's body. T describes the size of the tumor and whether it has invaded nearby tissue, N describes any lymph nodes that are involved, and M describes metastasis (spread of cancer from one body part to another).
C25385	Admission	Healthcare_Activity	Admission|ADM	The condition of being allowed to enter.
C25386	Cytometry	Cytological_Techniques	Cytometry|CM	Cytometry refers to the measurement of physical and /or chemical characteristics of cells, or, by extension, of other biological particles.
C25387	Benefits	Conceptual_Entities	Benefits|BENES	The positive effects of something.
C25388	Local-Regional	General_Modifier	Local|LOC|LOCRGN|Local-Regional|Regional	Affecting only a restricted part or area (of the body).
C25389	Chest	Body_Region	Chest|CH	The part of the human body between the neck and the diaphragm or the corresponding part in other vertebrates.
C25390	Index	Conceptual_Entities	Index|IX	A numerical scale used to compare variables with one another or with some reference number; a number used to select an element of a list, vector, array or other sequence.
C25391	Analysis	Clinical_or_Research_Activity	Analysis|AN	Examination and interpretation; the process of identifying an issue to be understood and addressed, modelling the issue, investigating the model results, interpreting the results, and possibly making a recommendation. Also the concept refers to the examination and study of a whole in terms of the parts composing it.
C25392	Manufacturer_Name	Properties_or_Attributes	Manufacturer|MANU|Make|Maker|Manufacturer Name	A person, an enterprise, or an entity that produces finished goods.
C25393	Comments	Document_Type	Comment|Comments|Remark|Remarks	A written explanation or criticism or illustration that is added to a book or other textual material.
C25394	Pill	Solid_Dosage_Form	Pill Dosage Form|PILL|Pill Dose Form|Pills	A dose of medicine in the form of a small pellet.
C25395	Telephone	Telecommunications	Telephone|PH|Phone	Electronic equipment that converts sound into electrical signals that can be transmitted over distances and then converts received signals back into sounds.
C25396	Access	Conceptual_Entities	Access|ACS	The right to obtain or make use of or take advantage of something (as services or membership); the right to enter.  Also, an act or means of approaching.
C25397	Application	Clinical_or_Research_Activity	Application|APPL|Applied|Apply	Putting something to a special use or purpose; the work of applying something.
C25398	Clinical	General_Modifier	Clinical|C|clinical	Having to do with the examination and treatment of patients.
C25399	Pelvic	Anatomy_Modifier	Pelvic|pelvic	Having to do with the pelvis (the lower part of the abdomen located between the hip bones).
C25400	Zubrod_Performance_Status	Performance_Status	Zubrod Performance Status|ECOG/Zubrod Score Performance Status|ZUB|Zubrod|Zubrod Score|Zubrod Score Performance Status	The Zubrod Score is one scale for indicating a patient's functional level: 0 Asymptomatic; 1 Symptomatic, fully ambulatory; 2 Symptomatic, in bed < 50% of the day; 3 Symptomatic, in bed > 50% of the day but not bedridden; 4 Bedridden; 5 Dead.
C25401	Abnormal	General_Modifier	Abnormal|ABN|abnormal	Deviating in any way from the state, position, structure, condition, behavior, or rule which is considered a norm.
C25402	Accession_Number	Identifier	Accession Number|ACC-NUM	A control number unique to an object, used to identify it among the other objects in a collection.
C25403	Accrual	Clinical_or_Research_Activity	Accrual|ACRU	The process of obtaining subjects for a study.
C25404	Action	Conceptual_Entities	Action	A thing done.
C25405	Activation_Date	Date	Activation Date|ACTV-DT	The date a trial was opened to accrual.
C25406	Additional	General_Modifier	Additional|ADD	Added; extra.
C25407	Address	Document_Type	Address|ADDR	A standardized representation of the geographical location of a person, business, building, or organization.
C25408	Adjacent	General_Modifier	Adjacent|ADJ	Next to or adjoining.
C25409	Administration	Healthcare_Activity	Administration|ADM|Treatment	The act of the dispensing, applying, or tendering of something to another, such as administration of a medicine.
C25410	Adverse_Drug_Experience_Report	Report	Adverse Drug Experience Report|ADR|Adverse Drug Report	Written notification to the FDA that a subject in a study has experienced an adverse event.
C25411	Advanced	General_Modifier	Advanced|ADV	Far along in course.
C25412	Affiliate	Conceptual_Entities	Affiliate|AFF	One associated with.
C25413	Affiliated	General_Modifier	Affiliated|AFF	To be associated with; this is usually used as a description of the relationship of a person to an institution.
C25414	Aliquot	Properties_or_Attributes	Aliquot|ALQ	Pertaining to a portion of the whole; any one of two or more samples of something, of the same volume or weight.
C25415	Alternative	General_Modifier	Alternative|ALT|Alternate	Available in place of something else.
C25416	Amended	General_Modifier	Amended|AMD	Corrected, or altered formally.
C25417	Amount	Retired_Concepts	Amount|AMT	The total quantity or number.
C25418	Amplification	Conceptual_Entities	Amplification|AMP	Addition of extra material.
C25419	Anal_Verge	Body_Region	Anal Verge	The transitional zone between the moist, hairless, modified skin of the anal canal and the perianal skin. (On-line Medical Dictionary)
C25420	Analyzed	Properties_or_Attributes	Analyzed|AN	Having been subject to examination and interpretation.
C25421	Anatomic	Anatomy_Modifier	Anatomic|ANAT	Relating to anatomy.
C25422	Anterolateral	Anatomy_Modifier	Anterolateral|AL	Denoting the area of the body in front and away from the middle line.
C25423	Apical	Anatomy_Modifier	Apical|AP	Relating to or located at the tip (an apex). (On-line Medical Dictionary)
C25424	Approach	Conceptual_Entities	Approach	A way of entering or leaving.
C25425	Approved	General_Modifier	Approved|APPR	Having been accepted by an authoritative body; established by authority; given authoritative approval.
C25426	Assignment	Conceptual_Entities	Assignment|ASSIGN	An allotting or an appointment to a particular person or use; or for a particular time or object.
C25427	At	General_Modifier	At	Used to indicate position, location, or state (American Heritage Dictionary)
C25428	Atypical	General_Modifier	Atypical|ATYP	Varying from the norm.
C25429	Available	General_Modifier	Available|AVAIL|Availability	Obtainable or accessible and ready for use or service.
C25430	Basis	Conceptual_Entities	Basis	The fundamental assumptions underlying an explanation or a relation that provides the foundation for something.
C25431	Begin	General_Modifier	Begin|BEG|Start	Have a beginning, in a temporal, spatial, or evaluative sense; the point in space or time where something begins.
C25432	Best	General_Modifier	Best	Having the most positive qualities.
C25433	Bimanual	General_Modifier	Bimanual|BIMAN	Relating to, or performed by, both hands.
C25434	Biochemical	General_Modifier	Biochemical|BIOCHEM	Of or relating to biochemistry; involving chemical processes in living organisms.
C25435	Biphasic	General_Modifier	Biphasic	Having two phases.
C25436	Blocks	Properties_or_Attributes	Blocks	Blocks refers to preserved specimens embedded in support material.  These are typically cut into thin slices for microscopic examination, with or without an enhancement such as staining.
C25437	Bone_Marrow_Stem_Cell_Transplantation	Bone_Marrow_Transplantation	Bone Marrow Stem Cell Transplantation|BMSCT	Bone Marrow Stem Cell Transplantation is a procedure to replace bone marrow with deficient function, which could be caused by the aggressive chemotherapy and/or radiation treatment for cancer or other condition, by neoplastic process per se, or by variety of hematological and immunological diseases, with healthy bone marrow stem cells. Transplantation may be autologous (an individual's own cells harvested prior to treatment), allogeneic (cells from another person), or syngeneic (cells donated by an identical twin).
C25438	Boost	Conceptual_Entities	Boost	Increase or raise.
C25439	Anatomic_Border	Body_Region	Anatomic Border|BDR|Border	The boundary of a surface or object.
C25440	Bottom	General_Modifier	Bottom	The lowest part, side, or surface of something.
C25441	Calcified	General_Modifier	Calcified	Having calcium deposited on or in an anatomic structure.
C25442	Cancer_and_Leukemia_Group_B	Clinical_Trials_Cooperative_Group	Cancer and Leukemia Group B|CALGB	A national clinical research group - network of 29 university medical centers, over 185 community hospitals and more than almost 3000 physicians - sponsored by the NCI, with its Central Office headquartered at the University of Chicago, and its Statistical Center located at Duke University, founded in 1955 with a goal of bringing together clinical and laboratory research.
C25443	Capacity	Characteristics	Capacity	The amount that can be contained.  It can refer to the volume that can be held, such as lung capacity, or the number of people that can be contained in a room or building.
C25444	Cavity	Anatomic_Structure_System_or_Substance	Body Cavity|CAV|Cavity	A natural hollow or sinus within the body.
C25445	Center	General_Modifier	Center|CTR	A point or area that is approximately central within some larger region or structure.
C25446	Change	Conceptual_Entities	Change|CHG	An alteration or modification.
C25447	Characteristics	Properties_or_Attributes	Characteristic|CHAR|Characteristics|Feature	Characteristics are the distinguishing qualities or prominent aspect of a person, object, action, process, or substance.
C25448	Clinical_Radiologic	General_Modifier	Clinical/Radiologic	Something observed through clinical or radiologic examination.
C25449	Closest	General_Modifier	Closest	Indicating the one of several that is the shortest distance away.
C25450	Coated	General_Modifier	Coated	To be covered with an outer layer or film.
C25451	Childrens_Oncology_Group	Retired_Concepts	Children's Oncology Group|COG	The Children's Oncology Group was formed by the merger of the four national pediatric cancer research organizations: the Children's Cancer Group, the Intergroup Rhabdomyosarcoma Study Group, the National Wilm's Tumor Study Group, and the Pediatric Oncology Group. The primary objective of the organization is to conduct clinical trials of new therapies for childhood cancer.
C25452	Collected	General_Modifier	Collected|COLL	Collected refers to objects having been brought together in one place.
C25453	Collection	Clinical_or_Research_Activity	Collection|COLL	The act of gathering things together.
C25454	Combined	General_Modifier	Combined|COMB	Made or joined or united into one or involving the joint activity of two or more.
C25455	Complicating	General_Modifier	Complicating|CM	Making more complex or intricate.
C25456	Concurrent	General_Modifier	Concurrent	Occurring or operating at the same time.
C25457	Condition	Properties_or_Attributes	Condition|COND	A state of being, such as a state of health or physical being.
C25458	Confirmed	General_Modifier	Confirmed|CONF	Having been established or verified.
C25459	Congestive	Disease_Modifier	Congestive|CONG	Relating to or affected by an abnormal collection of blood or other fluid.
C25460	Consent	Conceptual_Entities	Consent	Permission to do something.
C25461	Contact	Person	Contact Person|Contact	A person acting as a channel for communication between groups.
C25462	Coordinating	General_Modifier	Coordinating|COORD	Bringing into common action, movement, or condition
C25463	Count	Properties_or_Attributes	Count|CT	To determine the number or amount of something; the result of this activity.
C25464	Country	Geographic_Area	Country|CTRY	A collective generic term that refers here to a wide variety of dependencies, areas of special sovereignty, uninhabited islands, and other entities in addition to the traditional countries or independent states. (from CIA World Factbook 2002: http://www.cia.gov/cia/publications/factbook/docs/notesanddefs.html)
C25465	Clinical_Research_Associate	Research_Personnel	Clinical Research Associate|CRA	Person employed by a study sponsor or Contract Research Organization to monitor a clinical study at all participating sites. (from centerwatch.com glossary)
C25466	Criteria	Conceptual_Entities	Criterion|Criteria	A basis for comparison; a standard by which a judgment could be established; a reference point against which other things can be evaluated.
C25467	Critical	General_Modifier	Critical|CRIT	Being in or verging on a state of crisis or emergency; urgently needed; absolutely necessary.
C25468	Common_Toxicity_Criteria	Properties_or_Attributes	Common Toxicity Criteria|CTC|CTCAE|Common Terminology Criteria for Adverse Events	A standard terminology developed to report adverse events occurring in cancer clinical trials.  Common toxicity criteria (CTC) is used in study adverse event summaries and Investigational New Drug reports to the Food and Drug Administration.  The CTC contains a grading scale for each adverse event term representing the severity of the event. (NCI)
C25470	Cumulative	General_Modifier	Cumulative|CUM	Increasing by successive addition.
C25471	Current	Temporal_Modifier	Current	Occurring in or belonging to the present time.
C25472	Cycle	Conceptual_Entities	Cycle	An event or sequence of events that constitute round or succession of observable phenomena, recurring usually at regular or approximately regular time intervals and in the same sequence.
C25473	Daily	Temporal_Modifier	Daily|D	Occurring or done each day.
C25474	Data	Information	Data|Datum	A collection or single item of factual information, derived from measurement or research, from which conclusions may be drawn.
C25475	Declining	General_Modifier	Declining	Becoming progressively lower, growing weaker, or going from better to worse.
C25476	Delay	Conceptual_Entities	Delay	Time during which some action is awaited; inactivity resulting in something being put off until a later time.
C25477	Delayed	General_Modifier	Delayed	The state of being slower or later.
C25478	Dermal	Anatomy_Modifier	Dermal|DERM	Of or relating to or located in the dermis.
C25479	Designated	General_Modifier	Designated|DESC	Named or selected to an assignment.
C25480	Details	Conceptual_Entities	Details|DET	Particulars considered individually and in relation to a whole.
C25481	Detected	General_Modifier	Detected	Perceived, discerned, discovered or identified.
C25482	Diagnostic	General_Modifier	Diagnostic|DIAG	Characteristic or indicative of (e.g., a disease).
C25483	Dimension	Properties_or_Attributes	Dimension|DIM	The magnitude of something in a particular direction, especially length or width or height.
C25484	Discontinued	General_Modifier	Discontinued|DXD	Stopped permanently or temporarily.
C25485	Display	Properties_or_Attributes	Display|DISP	Exhibit, present, or demonstrate for viewing.
C25486	Disruption	Properties_or_Attributes	Disruption	An interruption or interference in continuity.
C25487	Dominant	General_Modifier	Dominant|DOM	Exercising influence or control.
C25488	Dose	Properties_or_Attributes	Dose|Dosage|Doses|dose	The amount of medicine taken, or radiation given, at one time.
C25489	Dryness	Characteristics	Dryness|DRYNS	The lack of natural or normal moisture.
C25490	During	Temporal_Modifier	During|DUR	At some point in a given period of time.
C25491	Eastern_Cooperative_Oncology_Group	Clinical_Trials_Cooperative_Group	Eastern Cooperative Oncology Group|ECOG	A cooperative group funded primarily by the NCI, one of the largest clinical cancer research organizations in the US, incorporating universities, medical centers, Community Clinical Oncology Programs, and Cooperative Group Outreach Programs with almost 6000 physicians, nurses, pharmacists, statisticians, and clinical research associates from the US, Canada, and South Africa. ECOG has more than 90 active clinical trials in all types of adult malignancies. Annual accrual is 6,000 patients, with more than 20,000 patients in follow-up.
C25492	Effect	Properties_or_Attributes	Effect	A phenomenon that follows and is caused by some previous phenomenon.
C25493	Elevated	General_Modifier	Elevated|ELEV	Raised or increased above normal levels or limits.
C25494	Elevation	Properties_or_Attributes	Elevation|ELEV	The condition of being elevated.
C25495	Emotional	General_Modifier	Emotional|EMOT	Excessively affected by emotion.
C25496	End	General_Modifier	End|Cease|Finish|Stop	The point or place at which something terminates in time, space, or extent.
C25497	Entire	General_Modifier	Entire|ENT	Constituting the full quantity or extent; complete.
C25498	Estimated	General_Modifier	Estimated|EST	To be calculated approximately.
C25499	Event	Conceptual_Entities	Event	Something that happens at a given place and time.
C25500	Examined	General_Modifier	Examined|EXM	Having been subjected to inspection or evaluation.
C25501	Expected	General_Modifier	Expected	Considered likely or probable; anticipated.
C25502	Extracapsular	Anatomy_Modifier	Extracapsular|EXTCP	Situated outside of a capsule, esp. outside the capsular ligament of a joint.
C25503	Extramedullary	Anatomy_Modifier	Extramedullary|EXTMD	Outside of, or unrelated to, any medulla, especially the medulla oblongata.
C25504	Extranodal	Anatomy_Modifier	Extranodal|EXTND	Situated outside of a node.
C25505	Extraprostatic	Anatomy_Modifier	Extraprostatic|EXPROS	Situated outside of the prostate.
C25506	Factor	Conceptual_Entities	Factor|FAC	Anything that contributes causally to a result.
C25507	Field	Conceptual_Entities	Field	Branch of knowledge;the region in which a particular type of force can be observed, often viewed as a space which was modified by the sources of the force which the field represents; an area of database record, or graphical user interface form, into which a particular item of data is entered.
C25508	Final	General_Modifier	Final|FIN	Conclusive in a process or progression.
C25509	First	Conceptual_Entities	First	Preceding all others in time or space or degree.
C25510	Fissural	Disease_Modifier	Fissural|FISL	Relating to or resembling a fissure.
C25511	Focus	Conceptual_Entities	Focus|Focal|Foci	Area of greatest concentration, attention, or activity; a central point or locus, especially of an infection.
C25512	Foreign	General_Modifier	Foreign	Foreign; not belonging to that in which it is contained; introduced from an outside source.
C25513	Formation	Properties_or_Attributes	Formation|FORM	The act of forming something or the structure formed.
C25514	Fraction	Conceptual_Entities	Fraction|FRACS|Fractions	A part, a fragment of a whole.
C25515	Frequency	Characteristics	Frequency|FREQ	The number of occurrences of something within a given time period.
C25516	From	General_Modifier	From	Used to indicate a specified place or time as a starting point; used to indicate a source, cause, agent, or instrument.
C25517	Full	General_Modifier	Full	Containing as much or as many as is possible or normal.
C25518	Function	Properties_or_Attributes	Function|FUNC	The normal action performed by a structure or device.
C25519	Further	General_Modifier	Further	To or at a greater distance in time or space.
C25520	Gingival	Anatomy_Modifier	Gingival|GING	Of or relating to the gums.
C25521	Gynecologic_Oncology_Group	Clinical_Trials_Cooperative_Group	Gynecologic Oncology Group|GOG	A non-profit NCI-supported organization with the purpose of promoting excellence in the quality and integrity of clinical and basic scientific research in the field of gynecologic malignancies. Approximately 45 individual clinical trials are active at any one time within GOG.
C25522	Granulopenic	Disease_Modifier	Granulopenic|GPEN	Relating to or resembling granulocytopenia.
C25523	Grouping	Properties_or_Attributes	Grouping|GP	A system for classifying things into groups or the activity of putting things together in groups.
C25524	HercepTest	Test|Test_Generic	HercepTest|HERCTS|Herceptest	An FDA approved test for the evaluation of HER2 protein overexpression in breast tumors.  It provides semi-quantitative results of p185HER2 (HER2 gene) overexpression in Bouin or formalin-fixed, routinely processed, paraffin-embedded breast cancer tissues by light microscopy.
C25525	Highest	General_Modifier	Highest|Apex|HST	Approaching or constituting a maximum; the highest point (of something).
C25526	Histologic	General_Modifier	Histologic|HIST|Histological	Pertaining to the combined microscopic physical features of cells and their surrounding extracellular environment in tissues.
C25527	Histologically	General_Modifier	Histologically|HIST	Involving the use of histology or histological techniques.
C25528	Hormonal	General_Modifier	Hormonal	Relating to hormones.
C25529	Hour	Unit_of_Potency|Unit_of_Time	Hour|HOUR|HR|Hours	A unit measure of time equal to 3,600 seconds or 60 minutes. It is approximately 1/24 of a median day.
C25530	International_Breast_Cancer_Study_Group	Professional_Organization_or_Group	International Breast Cancer Study Group|IBCSG	A group dedicated to innovative clinical research designed to improve the prognosis of women with breast cancer. Patients and investigators from six continents: Europe, Australia/ New Zealand, Africa, Asia, and North and South America, cooperate by participating in extensive clinical trials in the Adjuvant breast cancer setting. IBCSG has been a pioneer in research into combined hormonal therapy and chemotherapy, timing and duration of Adjuvant Therapies, and Quality of Life of breast cancer patients. (from ibcsg.org)
C25531	Immature	General_Modifier	Immature|IMMA	In an early period of life or development or growth.
C25532	Inclusion	Conceptual_Entities	Inclusion|INCL	The addition of somebody or something to, or the presence of somebody or something in, a group or mixture, particularly, a passive, usually temporary, product of cell activity within the cytoplasm or nucleus.
C25533	Increase	Conceptual_Entities	Increase|INCL	A process of becoming larger or more numerous or more important.
C25534	Induration	Properties_or_Attributes	Induration	The quality of being hard, the process of hardening, or an abnormally hard spot or place, particularly of the skin.  This is often associated with inflammation and infiltration of a neoplasm.
C25535	Inflammatory	Disease_Modifier	Inflammatory|INFLMY	Relating to inflammation.
C25536	Initial	General_Modifier	Initials|INIT	The first letter of a word, especially the first letter of each word in a proper name.
C25537	Initials	Retired_Concepts	Initials	The first letter of each word in a proper name.  A clinical trial may use a patients initials rather than their full name to ensure confidentiality.
C25538	Intake	Properties_or_Attributes	Intake|INTK	The act or process of consuming a substance or the substances, or the quantities thereof.
C25539	Intensity	Characteristics	Intensity|INTS|Intense	The degree or magnitude of strength, energy, or feeling.
C25540	Interlobar	Anatomy_Modifier	Interlobar|INTLB	Between lobes.
C25541	International	General_Modifier	International|INTL	Concerning or belonging to two or more nations.
C25542	Interruption	Conceptual_Entities	Interruption|INTR	A time interval during which there is a temporary cessation of something.
C25543	Interval	Temporal_Modifier	Interval|INR	The period of time or the distance separating two instances, events, or occurrences.
C25544	Into	General_Modifier	Into	Expressing entrance, or a passing from the outside of a thing to its interior parts.
C25545	Intraclavicular	Anatomy_Modifier	Intraclavicular|INFCLV	Within the clavicles.
C25546	Invaded	Properties_or_Attributes	Invaded|INV	Penetrated through tissue.
C25547	Involved	General_Modifier	Involved|INVL	To be part of or connected by participation, association or use.
C25548	Involvement	Properties_or_Attributes	Involvement|INVLT	To have a connection by participation or association or use; sharing in an activity or process.
C25549	Isolated	General_Modifier	Isolated|ISOL	Marked by separation of or from usually contiguous elements.
C25550	Largest	General_Modifier	Largest|LG	Greatest in size of those under consideration.
C25551	Last	General_Modifier	Last	Coming after all others in time or space or degree or being the only one remaining.
C25552	Lead	General_Modifier	Lead|LD	Be in charge of.
C25553	Leukemic_Cell	Malignant_Cell|Neoplastic_Hematopoietic_Cell	Leukemic Cell|LEUKCL	Malignant hematopoietic cell originating in the clonal proliferation of myeloid or lymphoid precursor that undergoes an aberrant and poorly regulated process of organogenesis resulted in arrested maturation and cell capacity for unlimited self-renewal.
C25554	Level	Properties_or_Attributes	Level|LVL	A position on a scale measuring intensity, quality, or amount.
C25555	Lower_Limit_of_Normal	Conceptual_Entities	Lower Limit of Normal|LLN	The lowest value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for particular laboratory result or other quantitative parameter.
C25556	Lobar	Anatomy_Modifier	Lobar|LB	Of or relating to or affecting a lobe.
C25557	Lobular	Anatomy_Modifier	Lobular|LBLR	Of or relating to or resembling a lobule.
C25558	Longest	General_Modifier	Longest|LGST	Having the greater length of two or the greatest length of several.
C25559	Loss	Conceptual_Entities	Loss	A gradual decline in amount or activity.
C25560	Lost	General_Modifier	Lost	Parted with; no longer held or possessed.
C25561	Lymphovascular	Anatomy_Modifier	Lymphovascular|LYMVAC	Of or relating to the lymphatic vessels.
C25562	Main	Conceptual_Entities	Main|MN	Most important; principal.
C25563	Margin	Conceptual_Entities	Margin|MARG	The boundary line or the area immediately inside the boundary.
C25564	Maximum	Conceptual_Entities	Maximum|MAX	The largest possible quantity or degree.
C25565	Mesorectal	Anatomy_Modifier	Mesorectal|MESRCT	Of or relating to the fold of peritoneum, or mesentery, attached to the rectum.
C25566	Metaplastic	Disease_Morphology_Modifier	Metaplastic|METPST	Pertaining to or characterized by metaplasia.
C25567	Metastatic_Recurrent	Disease_Clinical_Modifier	Metastatic/Recurrent|MET/RECR	Refers to a tumor that has spread to anatomic sites away from the original site of growth or has reappeared in any anatomic site. The vast majority of such tumors are malignant.
C25568	Microinvasive	Disease_Morphology_Modifier	Microinvasive|MICIV	Exhibiting or pertaining to microinvasion, the microscopic extension of malignant cells into adjacent tissue in carcinoma in situ.
C25569	Middle	General_Modifier	Middle|MID	An intermediate part or section; an area that is approximately central within some larger region.
C25570	Minimum	General_Modifier	Minimum|MIN	The smallest possible quantity.
C25571	Mode	Conceptual_Entities	Mode	A particular functioning condition or arrangement.
C25572	Modification	Properties_or_Attributes	Modification|MOD	The act of making a change or the change made.
C25573	Modified	General_Modifier	Modified|Changed|MOD	Changed or altered in form or character.
C25574	Molecular	General_Modifier	Molecular|MOL	Relating to or produced by or consisting of molecules.
C25575	Mononuclear	Anatomy_Modifier	Mononuclear|MONCLR	Possessing a single nucleus.
C25576	Monophasic	General_Modifier	Monophasic|MONPHSC	Occurring in or characterised by only one phase or stage.
C25577	Most_Recent	Temporal_Modifier	Most Recent	Most Recent; nearest to the present.
C25578	Myocardial	Anatomy_Modifier	Myocardial|MYOCD	Of or pertaining to the myocardium.
C25579	Myometrial	Anatomy_Modifier	Myometrial|MYMTR	Of or pertaining to the myometrium.
C25580	N_Stage	Properties_or_Attributes	N Stage|N	One criteria of the TMN staging system.  N refers to the extent of lymph node involvement.
C25581	North_Central_Cancer_Treatment_Group	Clinical_Trials_Cooperative_Group	North Central Cancer Treatment Group|NCCTG	A national clinical research group sponsored by the NCI. The research base for NCCTG is located at Mayo Clinic in Rochester, Minn. NCCTG consists of a network of more than 1,000 cancer specialists at community clinics, hospitals and medical centers in 25 states in US, two Canadian provinces and Mexico. NCCTG specializes in researching methods of treating and preventing cancer, and in researching methods to alleviate the side effects of cancer and cancer treatments.
C25582	National_Cancer_Institute_of_Canada	Professional_Organization_or_Group	National Cancer Institute of Canada|NCIC	Acts in concert with its partner the Canadian Cancer Society, and with The Terry Fox Foundation, to provide support for cancer research and related programs undertaken at Canadian universities, hospitals and other research institutions. (www.ncic.cancer.ca)
C25583	Nearest	General_Modifier	Nearest|NRST	Most near in time or space.
C25584	Nervous	Anatomy_Modifier	Nervous|NRVS	Of or relating to the nervous system.
C25585	Nevus_Cell	Neoplastic_Melanocyte	Nevus Cell|Nevus Cells	A neoplastic cutaneous melanocyte that characterizes benign and atypical cutaneous neoplastic lesions called nevi.
C25586	New	General_Modifier	New	Having no previous example or precedent or parallel.
C25587	Newly_Diagnosed	Disease_Clinical_Modifier	Newly Diagnosed|NEW-DX	Very recently determined.
C25588	Non-Malignant	Disease_Morphology_Modifier	Non-Malignant|NMAL|Non Malignant|Nonmalignant|nonmalignant	Not cancerous.
C25589	Non-Measurable	Disease_Gross_Finding_Modifier	Non-Measurable|NMSR	Not possible to be measured.
C25590	Non-Protocol	General_Modifier	Non-Protocol|NPROT	Treatment not specified in a protocol.
C25591	Non-Surgical	General_Modifier	Non-Surgical|NSURG	Not pertaining to or amenable to surgery.
C25592	Non-Target	General_Modifier	Non-Target|NTARGET	Other than the one for which something is done.
C25593	Non-Visceral	Anatomy_Modifier	Non-Visceral|NVISCERAL	Not relating to or affecting the viscera.
C25594	Not	Conceptual_Entities	Negation|Negated|Non|Non-|Not	An operation in which a term denies or inverts the meaning of another term or construction.
C25595	Nottingham_Score	Disease_Modifier	Nottingham Score|NS	A numeric representation combining three histologic reporting elements, tubulin formation, nuclear pleomorphism and mitotic count, to determine the grade of breast cancer.  The Nottingham Score is a factor in determining the Nottingham Prognostic Index. (NCI)
C25596	Breast_Feeding	Personal_Behavior	Breast Feeding|NSG|Nursing	The nursing of an infant at the mother's breast.
C25597	Nutritional	General_Modifier	Nutritional|NUT	Of or relating to or providing nutrition.
C25598	Observation	Clinical_or_Research_Activity	Observation|OBS	Observation; watching something and taking note of what happens.
C25599	Observed	Properties_or_Attributes	Observed|OBS	Ascertained or determined through monitoring or observation.
C25600	Occupational	General_Modifier	Occupational|OCC	Of or relating to the activity or business for which a person is trained.
C25601	Off-Treatment	General_Modifier	Off Treatment|OTX|Off-Treatment	When a patient is not receiving therapy they are considered off treatment.  In clinical trials, a dosing schedule may require a patient to stop medication for a period of time, then resume, such as 28 days on and 7 days off. Compare with 'Off Study'.
C25602	Opposite	General_Modifier	Opposite|OPP	Being directly across from each other; being on the other side or direction of; the other one of a complementary pair.
C25603	Optional	General_Modifier	Optional|OPT	Possible but not necessary; left to personal choice.
C25604	Original	General_Modifier	Original|ORIG	Preceding all others in time or being as first made or performed.
C25605	Overall	General_Modifier	Overall	Including everything.
C25606	Palpable	Disease_Gross_Finding_Modifier	Palpable|PALP|Palpable Disease|palpable disease	A term used to describe cancer that can be felt by touch, usually present in lymph nodes, skin, or other organs of the body such as the liver or colon.
C25607	Parametrial	Anatomy_Modifier	Parametrial|PARMRL	Regions near to the parametrium.
C25608	Participating	General_Modifier	Participating|PARTIC	Taking part in an activity.
C25609	Past	Temporal_Modifier	Past	Before the present time.
C25610	Pathologic	Disease_Modifier	Pathologic|P	Caused by or altered by or manifesting disease or pathology.
C25611	Pectoral	Anatomy_Modifier	Pectoral|PEC	Of or pertaining to the chest.
C25612	Penetration	Conceptual_Entities	Penetration|PENE	The act of entering into or through something.
C25613	Percentage	General_Modifier	Percentage|PTG	A fraction or ratio with 100 understood as the denominator.
C25614	Pericolic	Anatomy_Modifier	Pericolic|PERCLC	Surrounding the colon.
C25615	Perineural	Anatomy_Modifier	Perineural|PERNRL|perineural	(pear-ih-NOOR-al) Around a nerve or group of nerves.
C25616	Period	Temporal_Modifier	Period|PD	An interval of time.
C25617	Periprostatic	Anatomy_Modifier	Periprostatic|PERPST	Surrounding the prostate.
C25618	Physical	General_Modifier	Physical|PHYS	Of or pertaining to the body.
C25619	Planned	General_Modifier	Planned|P	Devised, contrived, or formed in design.
C25620	Platinum-Based	General_Modifier	Platinum-Based|PTBASED	Derived from or containing platinum.
C25621	Postal_Code	Code	Postal Code|POSTAL-CD	Any system designed to expedite the sorting and delivery of mail by assigning a series of alphanumeric codes to each delivery area.  Also used to refer to any individual delivery area code.
C25622	Posterior	Anatomy_Modifier	Posterior|POST	Denoting the back surface of the body; at or near the hind end in quadrupeds or toward the spine in primates.
C25623	Post-Operative	Retired_Concepts	Post-Operative|PO	Relating to or occurring during the period immediately following a surgical operation.
C25624	Premalignant	Disease_Morphology_Modifier	Premalignant|PREMAL|Pre-Malignant|Precancerous|precancerous|premalignant	(pre-KAN-ser-us) A term used to describe a condition that may (or is likely to) become cancer.
C25625	Preparation	Clinical_or_Research_Activity	Preparation|PREP	The act or process of making something ready; also a medication made ready for administration; also an anatomic or pathologic specimen made ready and preserved for study.
C25626	Present	General_Modifier	Present|In|PRES	Being or existing in a specified place or at the specified time.
C25627	Previous	Temporal_Modifier	Previous|PREV	Occurring prior to something else.
C25628	Principal	General_Modifier	Principal|PRIN	First or foremost in importance.
C25629	Prior	Temporal_Modifier	Prior|Before|Preceding	Earlier in time or order.
C25630	Progress	Conceptual_Entities	Progress|PROG	The act of moving forward toward a goal.
C25631	Projected	Retired_Concepts	Projected	Calculated, estimated, or predicted based on present data or trends.
C25632	Province	Geographic_Area	Province|PROV	A region, district or division of a country; a tract; a portion a state, especially one remote from the capital.
C25633	Proximity	Conceptual_Entities	Proximity|PROX	The state or quality of being next; immediate nearness either in time, place, blood or alliance.
C25634	Purpose	Conceptual_Entities	Purpose|PURPS	Reason or intention.
C25635	Qualifying	Conceptual_Entities	Qualifying|QLFY	Success in satisfying a test or requirement.
C25636	Rate	Temporal_Modifier	Rate	A measurement of degree, speed, or frequency relative to time.
C25637	Reaction	Properties_or_Attributes	Reaction|RCTB	A response generated by a stimulus.
C25638	Reason	Conceptual_Entities	Reason|RSN|RSNS|Reasons	An explanation of the cause of some phenomenon or action.
C25639	Received	General_Modifier	Received|RECD	To have taken, accepted, or gotten something offered.
C25640	Reduced	General_Modifier	Reduced|RED	Made less in size or amount or degree.
C25641	Reference	Document_Type	Reference|Bibliographic Reference|REF	A note acknowledging a source of information or quoting a passage.
C25642	Referring	General_Modifier	Referring|REF	Sending or directing for treatment, information, or a decision.
C25643	Regional	General_Modifier	Regional|RGN|regional	In oncology, describes the body area right around a tumor.
C25644	Registered	General_Modifier	Registered|REG	Listed or recorded officially; officially qualified or enrolled.
C25645	Registering	General_Modifier	Registering|REG	The act of listing or recording officially.
C25646	Registration	Clinical_or_Research_Activity	Registration|REG	The act of enrolling; an entry in a register.
C25647	Regular	General_Modifier	Regular|REG	Customary, usual, or at fixed intervals; conforming to a standard or pattern.
C25648	Related	Conceptual_Entities	Relationship|R/T|Related	A state of connectedness between people, objects, or events; to be associated or connected with something.
C25649	Remaining	General_Modifier	Remaining|RMNG	Residual, left over or behind; enduring or persisting.
C25650	Removed	General_Modifier	Removed|Out|RMVD	Taken out of, separated from, or eliminated.
C25651	Reporting	Clinical_or_Research_Activity	Reporting|REP	The act of providing a short account.
C25652	Required	General_Modifier	Required|REQ	Necessary, not optional.
C25653	Resectable	Disease_Treatment_Modifier	Resectable|resectable	(ree-SEK-tuh-bull) Part or all of an organ that can be removed with surgery.
C25654	Resected	Disease_Treatment_Modifier	Resected|RES|resected	Having been removed by surgery.
C25655	Resolution	Conceptual_Entities	Resolution|RSLN	Return to the normal structure and/or function, e.g. the subsidence of a pathologic process, as the subsidence of an inflammatory lesion or new growth.
C25656	Respiratory	General_Modifier	Respiratory|RESP	Pertaining to respiration.
C25657	Responsible_Person	Person	Responsible Person|Person Responsible|RSPBL|Responsible	A person worthy of responsibility or trust or one held accountable.
C25658	Restart	Properties_or_Attributes	Restart	To take up or begin anew; resume.
C25659	Retrieval	Clinical_or_Research_Activity	Retrieval|RTVL	The operation of accessing information from storage.
C25660	Retrotracheal	Anatomy_Modifier	Retrotracheal|RETRCH	Denoting the area behind the trachea.
C25661	Reviewing	General_Modifier	Reviewing|RVWG	Reexamining or reconsidering.
C25662	Sampling	Clinical_or_Research_Activity	Sampling|SMPLG	The selection and obtaining of small representative quantities of biological material for the purpose of analysis; also, in biomedical statistics, sampling is the selection and implementation of statistical observations in order to estimate properties of an underlying population; also, in environmental science, the collection of representative specimens analyzed to characterize site conditions.
C25663	Satellite	General_Modifier	Satellite|SATLT	Situated near; accompanying.
C25664	Scale	Conceptual_Entities	Scale	An ordered reference standard used to measure incremental changes.
C25665	Scheme	Document_Type	Scheme	An elaborate and systematic plan of action.
C25666	Second	General_Modifier	Second|SEC	Coming next after the first in position in space or time or degree or magnitude.
C25667	Secondary	Disease_Clinical_Modifier	Secondary|SEC	Derived as a result of a primary condition; not direct or immediate; of second rank or importance or value.
C25668	Section	Specimen	Section|SEC	A very thin slice (of tissue or mineral or other substance) for examination under a microscope.
C25669	Security	Conceptual_Entities	Security|SECR	Services provided to prevent, deter, detect and/or document crime, fire, disorder or violations of company rules.
C25670	Self-Administered	General_Modifier	Self-Administered|SA	Self given or applied.
C25671	Seminal	Anatomy_Modifier	Seminal|SEMN	Pertaining to or containing or consisting of semen.
C25672	Sent	General_Modifier	Sent	Caused or enabled to go or be conveyed or transmitted.
C25673	Sequence	Conceptual_Entities	Sequence|SEQ	A serial arrangement in which things follow in logical order or a recurrent pattern.
C25674	Series	Conceptual_Entities	Series|SER	A group or succession of objects or substances arranged in regular order in space or time, connected by a like relation, or forming a kind of chain; also, a taxonomic category of fungi.
C25675	Serum_Immunologic	General_Modifier	Serum Immunologic|SRM-IMLG	Pertaining to serologic tests to determine the presence of immunologic factors or evidence of an immune response.  (NCI)
C25676	Severity	Conceptual_Entities	Severity|SVRTY	Used of the degree of something undesirable e.g. pain or weather; also, strictness.
C25677	Shape	Conceptual_Entities	Shape	The spatial arrangement of something as distinct from its substance.
C25678	Signature	Document_Type	Signature|SIG	Individual's name or personal mark, used to sign documents and employed to signify that the writing which precedes accords with one's wishes and intentions; an identifying feature or characteristic of something or someone; an alternative term for motif or pattern; the part of the prescription that contains directions to the patient for taking of medicine.
C25679	Signed	General_Modifier	Signed|SIG	Having a handwritten signature.
C25680	Sister	Relative	Sister|SIS	A female sibling.
C25681	Size	Conceptual_Entities	Size|SZ	The physical magnitude of something.
C25682	Slice	Specimen	Slice	A thin flat piece cut off of some object.
C25683	Source	Conceptual_Entities	Source	Where something is available or from where it originates.
C25684	Special	General_Modifier	Special|SPEC	Surpassing what is common or usual or expected.
C25685	Specify	Conceptual_Entities	Specify|SPEC	Be specific about something; define clearly.
C25686	Social_Security_Number	Personal_Attribute	Social Security Number|SSN	A nine digit taxpayer identification number resembling "123-45-6789" which is issued to an individual by the Social Security Administration of the United States federal government.
C25687	State	Properties_or_Attributes	State	The way something is with respect to its main attributes.
C25688	Status	Conceptual_Entities	Status|STAT	A condition or state at a particular time.
C25689	Stratification	Clinical_or_Research_Activity	Stratification|STRAT	The process of classifying patients into strata as part of the randomization process or for purposes of data analysis.
C25690	Street_Address	Address	Street Address|ST-ADDR|Street	The street name and building number where a person or organization can be found.
C25691	Subcarinal	Anatomy_Modifier	Subcarinal	Below the carina.
C25692	Subcategory	Category	Subcategory|SUBCAT	A subdivision that has common differentiating characteristics within a larger category.
C25693	Subgroup	Grouping	Subgroup|SUBGP	A subdivision of a larger group with members often exhibiting similar characteristics.
C25694	Submission	Conceptual_Entities	Submission|SUBM	Something submitted for the judgment or consideration of others.
C25695	Submitted	General_Modifier	Submitted|SUBM|Submission	Referred for judgment or consideration; handed over.
C25696	Subtype	Conceptual_Entities	Subtype|SUBTP	A group forming a type within a larger type.
C25697	Sum	Conceptual_Entities	Sum	The final aggregate amount.
C25698	Surgical	General_Modifier	Surgical|SURG	Of or relating to or involving or used in surgery or requiring or amenable to treatment by surgery.
C25699	Southwest_Oncology_Group	Clinical_Trials_Cooperative_Group	Southwest Oncology Group|SWOG	An NCI-sponsored cooperative group, an adult cancer clinical trials organization, one of the largest in the world. The group was established in 1956 and is headquartered in San Antonio, TX. Its network consists of almost 4,000 of the physicians at 283 institutions throughout the US and Canada. The major goal of the SWOG since 1990 has been to enroll more women and minority patients in cancer treatment and control research trials.
C25700	System	Conceptual_Entities	System|SYS	A group of independent but interrelated elements comprising a unified whole.
C25701	Taken	Conceptual_Entities	Taken	Having accepted for some purpose; ingested as a medication.
C25702	Target	General_Modifier	Target|TGT	The goal intended to be attained; something to point or shoot at.
C25703	Term	Conceptual_Entities	Term|TRM	A limited period of time.
C25704	Text	Document_Type	Text|TXT	The words of something written.
C25705	Treating	General_Modifier	Treating	Providing treatment for.
C25706	Upper_Limit_of_Normal	Conceptual_Entities	Upper Limit of Normal|ULN	The top value of the range of statistical characteristics that are supposed to represent accepted standard, non-pathological pattern for particular laboratory result or other quantitative parameter.
C25707	Uncoated	General_Modifier	Uncoated	Not having a coating.
C25708	Unfiltered	General_Modifier	Unfiltered|UNFLT	Lacking a filter.
C25709	Unit_of_Measure	Properties_or_Attributes	Unit of Measure|UOM|Unit of Measurement|Units of Measure	A named quantity in terms of which other quantities are measured or specified, used as a standard measurement of same kinds.
C25710	Update	Conceptual_Entities	Update|UPDT	Bring up to date; supply with recent information or technology.
C25711	Urinary	Anatomy_Modifier	Urinary|URNY|urinary	Having to do with urine or the organs of the body that produce and get rid of urine.
C25712	Value	Conceptual_Entities	Value|VAL	A numerical quantity measured or assigned or computed.
C25713	Variation	Conceptual_Entities	Variation|Deviation|VAR|Variant	An alteration or difference from a norm or standard.
C25714	Version	Conceptual_Entities	Version|VER|Versioned	A form or variant of a type or original.
C25715	Vertebral	Anatomy_Modifier	Vertebral|VERTBL	Of or relating to or constituting vertebrae.
C25716	Visit	Personal_Behavior	Visit|VST	The act of going to see some person or place or thing; it can cover a short or long period but refers to a non-permanent arrangement.
C25717	Vital_Status	Personal_Attribute	Vital Status|VST	The state or condition of being living or deceased; also includes the case where the vital status is unknown.
C25718	Without	General_Modifier	Without|W/O	Used to indicate the absence or lack of something or someone. (from Merriam-Webster OnLine)
C25719	Worst	General_Modifier	Worst	To the highest degree of inferiority or badness; the least favorable outcome.
C25720	Zip_Code	Postal_Code	Zip Code|ZIP	A system designed to expedite the sorting and delivery of mail by assigning a series of numbers to each delivery area in the United States.  Also used to refer to any individual delivery area code. (from the American Heritage Dictionary)
C25721	Mesenchymal	Anatomy_Modifier	Mesenchymal|MESCYL|mesenchymal	Refers to cells that develop into connective tissue, blood vessels, and lymphatic tissue.
C25722	Adjuvant_CADSR	General_Modifier	Adjuvant|ADJ	serving to aid or contribute; auxiliary. (Merriam-Webster OnLine)
C25723	Dermoid	Anatomy_Modifier	Dermoid|DERMD	Dermoid; resembling skin; skinlike.
C25724	Hilar	Anatomy_Modifier	Hilar|hilar	Refers to the area where nerves and blood vessels attach to an organ.
C25725	Intent	Properties_or_Attributes	Intent	An anticipated outcome that is the meaning or purpose for actions taken, thus guiding your planned actions.
C25726	Pancreatic	Anatomy_Modifier	Pancreatic|pancreatic	Having to do with the pancreas.
C25727	M_Stage	Properties_or_Attributes	M Stage|M	One criteria of the TMN staging system.  M refers to the presence of metastasis.
C25728	T_Stage	Properties_or_Attributes	T Stage|T	One criteria of the TMN staging system.  T refers to the extent of tumor involvement at the primary site (T, followed by a number indicating size and depth of invasion).
C25729	Adherence	Personal_Attribute	Adherence|ADHR	The act of abiding by a stated treatment plan or protocol.
C25730	Concomitant	General_Modifier	Concomitant	Accessory, accompanying especially in a subordinate or incidental way, occurring or existing during the same period of time.
C25731	Cribriform	General_Modifier	Cribriform|CRIB|cribriform	Having the appearance of a sieve: containing many perforations.
C25732	Ductal	Anatomy_Modifier	Ductal	Related to, or having the quality of, a duct.
C25733	En_Bloc	General_Modifier	En Bloc	In a lump; as a whole; used to refer to autopsy techniques in which visceral organs are removed in large blocks allowing the prosector to retain a continuity in organ architecture during the subsequent dissection. (On-line Medical Dictionary)
C25734	Breslow_Thickness	Thickness	Breslow Thickness|BRES|Breslow|Breslow's Thickness	The measurement in millimeters of the vertical thickness of primary cutaneous melanoma.  Breslow thickness is measured from the granular layer of the epidermis, or the ulcer base (if ulcerated), to the deepest tumor cells.  It is used in staging of melanoma. (NCI)
C25735	Inhaling	Respiratory_Process	Inhaling	breathing in.
C25736	Fibrinogen	Protein_or_Riboprotein_Complex	Fibrinogen|FBG	A fibrillar protein present in blood plasma; it converts to fibrin during the process of blood clot formation.
C25737	Identified	General_Modifier	Identification|ID|Identified	The procedure of having an identity established.
C25738	Infarction	Pathologic_Process	Infarction|INF	Infarction is localized pathological necrosis of tissue resulting from obstruction of the blood supply usually by a thrombus, an embolus, or vascular torsion. (NCI)
C25739	Metabolism	Retired_Concepts	Metabolism
C25740	Erection	Reproductive_System_Process	Erection|EREC	Erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male.
C25741	Physician	Medical_Occupation	Physician|DR	A licensed medical practitioner.
C25742	Pregnancy	Reproductive_Process	Pregnancy|PREG	Pregnancy is the state or condition of having a developing embryo or fetus in the body (uterus), after union of an ovum and spermatozoon, during the period from conception to birth. (NCI)
C25744	Urination	Renal_and_Urologic_Process	Urination|URNA	Urination is the discharge of urine. (NCI)
C25745	Failure	Pathologic_Process	Failure|FLR	The loss of the ability to function normally; something that does not accomplish its intended purpose.
C25746	Recovery	Organismal_Process	Recovery|RECVY	A healing process and/or an outcome implying relative health.  The term is typically used in the context of direct and indirect effects of sickness or injury.
C25747	Creatinine_Clearance	Test|Test_Generic	Creatinine Clearance|CC	Measurement of the clearance of endogenous creatinine, used for evaluating the glomerular filtration rate.
C25748	Iron_Binding_Capacity	Test|Test_Generic	Iron Binding Capacity|IBC	The capacity of iron-binding protein in serum (transferrin) to bind serum iron. (On-line Medical Dictionary)
C25749	Pulse	Personal_Attribute	Pulse|P|Pulse Rate	The rhythmic wave within the arteries occurring with each contraction of the left ventricle.
C25751	Deterioration	Disease_Progression	Deterioration|DETER	Deterioration is a symptom or state of reduced quality or strength. (NCI)
C25753	Bronchoscopist	Medical_Occupation	Bronchoscopist	A doctor or technician who operates a bronchoscope.
C25754	Infiltration	Biophysical_Process	Infiltration|INFIL	Infiltration is the process of the diffusion or accumulation in a tissue or cells of a substance not normal to it or in amounts above normal. (NCI)
C25755	Response	Conceptual_Entities	Response|RESP|response	Any act or phenomena, or behavior, constituting a reply or reaction of a living organism or its part to some foregoing stimulus or agent.
C25756	Translocation	DNA_Sequence_Rearrangement	Translocation|TRNSL	Translocation is the movement of a physical object from one place to another. (NCI)
C25757	Ulceration	Pathologic_Process	Ulceration|ULCN|ulceration	The formation of a break on the skin or on the surface of an organ.  An uncer forms when the surface cells die and are cast off.  Ulcers may be associated with cancer and other diseases.
C25758	HPV-16_E7_Peptide	Vaccine_Antigen	HPV-16 E7 Peptide (12-20)|HPV-16 E7 Peptide|Human Papillomavirus 16 E7 Peptide|Human Papillomavirus 16 E7 Peptide (12-20)	A peptide vaccine consisting of amino acids 12 through 20 of the viral oncoprotein human papillomavirus (HPV) 16 E7. Vaccination with HPV-16 E7 peptide may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for HPV-16 E7, resulting in decreased tumor growth. HPV-16 infection is tumorigenic and highly associated with cervical cancer. (NCI04)
C25759	Clinical_Study_Element	Conceptual_Entities	Clinical Study Element
C25760	DNA_Crosslinking_Agent	DNA_Binding_Agent	DNA Crosslinking Agent|DNA Crosslinker	Agents able to covalently bind to DNA causing inter- or intra-stranded cross-linking of DNA.  The cross-linking results in misreading of the DNA code and inhibition of DNA synthesis. (NCI)
C25761	Surgically_Created_Structure	Other_Anatomic_Concept	Surgically Created Structure	Any anatomical feature created by surgery.  This includes structures created to mimic the function of a structure removed by surgery or destroyed by disease.
C25762	Cardiovascular_System_Part	Body_Part	Cardiovascular System Part|Circulatory System Part
C25763	Gastrointestinal_System_Part	Body_Part	Gastrointestinal System Part
C25765	Secondary_Acute_Myeloid_Leukemia	Acute_Myeloid_Leukemia	Secondary Acute Myeloid Leukemia|Secondary AGL|Secondary AML|Secondary Acute Granulocytic Leukemia|Secondary Acute Myeloblastic Leukemia|Secondary Acute Myelocytic Leukemia|Secondary Acute Myelogenous Leukemia	An acute myeloid leukemia secondary to a myelodysplastic syndrome or therapy-related.  (WHO, 2001) -- 2003
C25767	Cervical_Neck_Region	Body_Region	Cervical Neck Region
C25768	Digestive_System_Part	Retired_Concepts	Digestive System Part
C25769	Musculoskeletal_System_Part	Body_Part	Musculoskeletal System Part
C25770	Mucous_Membrane	Retired_Concepts	Mucous Membrane|mucosa|mucous membrane
C25771	Metastatic_Malignant_Testicular_Germ_Cell_Tumor	Stage_III_Testicular_Cancer	Metastatic Malignant Testicular Germ Cell Tumor|Metastatic Testicular Cancer
C25772	Cerebral_Cavernous_Malformations-1_Protein	Signaling_Protein	Cerebral Cavernous Malformations 1|Ankyrin Repeat-Containing Protein KRIT1|CAM|CCM1|KRIT1|Krev Interaction Trapped 1	Ankyrin Repeat-Containing Protein KRIT1, encoded by the CCM1 gene, interacts with ICAP-1 and may be involved in bidirectional signaling between integrin molecules and the cytoskeleton. KRIT1 may help determine endothelial cell shape and function in response to cell-cell and cell-matrix interactions by guiding cytoskeletal structure. Defects in the CCM1 gene are responsible for the development of cerebral cavernous malformations, a relatively rare disease causing vascular malformations that may involve any part of the central nervous system. KRIT1 may affect cell adhesion processes via integrin signaling in CCM1 pathogenesis. KRIT1 also interacts with RAP1A (a member of the Ras family of GTPases) and may be involved in the RAP1A signal transduction pathway in vasculogenesis or angiogenesis. KRIT1 contains 4 ankyrin repeats, 1 band 4.1-like domain, and 1 FERM domain. (From NCI)
C25773	Cyclin-B2	Cyclin	Cyclin B2|CCNB2|G2/Mitotic-Specific Cyclin B2	Cyclin B2, encoded by the CCNB2 gene, is a member of the cyclin family of CDK kinase regulatory subunits, specifically the B-type cyclins. Cyclin B2 is primarily associated with the Golgi region. Cyclin B2 is essential for the control of the cell cycle at the G2/M (mitosis) transition. Cyclin B2 interacts with the CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex, activating and imparting substrate specificity to the complex. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/CDC2 may play a key role in transforming growth factor beta-mediated cell cycle control. Cyclin B2 accumulates steadily during G2 and is abruptly destroyed at mitosis. Overexpression of cyclins B, resulting from different mechanisms, could contribute, through an alteration of the spindle checkpoint, to the chromosomal instability observed in cancer. (From LocusLink, PMID and NCI)
C25774	Phalanx_of_the_Foot	Bone_of_the_Lower_Extremity	Phalanx of the Foot|Phalanges of Foot|Phalanx of Foot
C25775	Chemokine_Receptor_Gene	Receptor_Gene	Chemokine Receptor Gene	Chemokine Receptor Genes (GPCR Family) encode cell surface Chemokine Receptors, seven-transmembrane G protein-coupled receptor glycoproteins that bind to chemokines and mediate the migration of pro-inflammatory cells. Like chemokines, the chemokine receptors can be divided, according to variations in a shared cysteine motif, into at least three structural branches: CR, CCR, and CXCR. (NCI)
C25776	C-C_Motif_Chemokine_Receptor-1	Chemokine_Receptor	Chemokine (C-C Motif) Receptor 1|C-C CKR-1|C-C Chemokine Receptor Type 1|CC-CKR-1|CCR-1|CCR1|CKR-1|CMKBR1|CMKR1|HM145|LD78 Receptor|MIP-1 Alpha-R|MIP-1Alpha-R|MIP1aR|Macrophage Inflammatory Protein-1 Alpha Receptor|RANTES Receptor|RANTES-R	Chemokine (C-C Motif) Receptor 1, encoded by the CCR1 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene may have roles in host protection from inflammatory response, and susceptibility to virus and parasite. (From LocusLink and NCI)
C25777	C-C_Motif_Chemokine_Receptor-5	Chemokine_Receptor	Chemokine (C-C Motif) Receptor 5|C-C CKR-5|C-C Chemokine Receptor Type 5|CC-CKR-5|CCCKR5|CCR-5|CCR5|CCR5 Protein|CD195 Antigen|CHEMR13|CKR-5|CKR5|CMKBR5|Chemokine (C-C) Receptor 5|HIV-1 Fusion Co-Receptor	Chemokine (C-C Motif) Receptor 5, encoded by the CCR5 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. This receptor is expressed by T cells and macrophages, and is an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene is associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene is also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. (From LocusLink and NCI)
C25778	C-C_Motif_Chemokine_Receptor-6	Chemokine_Receptor	Chemokine (C-C Motif) Receptor 6|BN-1|C-C CKR-6|C-C Chemokine Receptor Type 6|CC-CKR-6|CCR-6|CCR6|CCR6 Protein|CKR-L3|CKR6|CKRL3|CMKBR6|Chemokine (C-C) Receptor 6|Chemokine Receptor-Like 3|DCR2|DRY-6|DRY6|G Protein-Coupled Receptor 29|GPR-CY4|GPR29|GPRCY4|LARC Receptor|STRL22|Seven-Transmembrane Receptor, Lymphocyte, 22	Chemokine (C-C Motif) Receptor 6, encoded by the CCR6 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. The CCR6 gene is preferentially expressed by immature dendritic cells and memory T cells. This receptor mediates intracellular calcium flux and binds specifically to the CC chemokine macrophage inflammatory protein 3 alpha (MIP-3 alpha). It is important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. (From LocusLink and NCI)
C25779	C-C_Motif_Chemokine_Receptor-8	Chemokine_Receptor	Chemokine (C-C Motif) Receptor 8|CCR8|CKR-L1|CKRL1|CMKBR8|CMKBRL2|CY6|Chemokine (C-C) Receptor 8|Chemokine (C-C) Receptor-Like 2|GPR-CY6|TER1	Chemokine (C-C Motif) Receptor 8, encoded by the CCR8 gene, is a member of the beta chemokine receptor family and a seven transmembrane protein similar to G protein-coupled receptor. This receptor is expressed preferentially in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) are ligands of this receptor. This receptor and its ligands regulate monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. (From LocusLink and NCI)
C25781	C-C_Motif_Chemokine_Receptor-9	Chemokine_Receptor	Chemokine (C-C Motif) Receptor 9|C-C Chemokine Receptor D6|C-C Chemokine Receptor Type 9|CC-Chemokine Receptor CCR10|CC-Chemokine-Binding Receptor JAB61|CCBP2|CCR-9|CCR10|CCR9|CMBRK9|Chemokine Binding Protein 2|Chemokine-Binding Protein D6|D6|hD6	Expressed in placenta, lung, lymphatic endothelia, lymph nodes, intestinal mucosa/submucosa, hemopoietic cells, and fetal liver by human CCBP2 Gene (GPCR1/Beta Chemokine Receptor Family), Chemokine (C-C Motif) Receptor 9 is a seven transmembrane G protein-coupled receptor for many beta chemokines (MCP1, MIP1-alpha, RANTES, MCP3) and is critical for recruitment of effector immune cells to inflammation sites. CCBP2 does not mediate intracellular calcium flux but may function in chemokine-driven recirculation of leukocytes. (NCI)
C25784	RAS_Family_Gene	G_Protein_Gene	RAS Family Gene
C25785	KRAS2_Gene	RAS_Family_Gene	KRAS Gene|C-K-RAS|K-RAS2A|K-RAS2B|K-Ras 2A|KI-RAS|KRAS|KRAS2|RASK2|v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog	Human v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (KRAS2) gene, located at 12p12.1, encodes transforming protein p21 (K-Ras 2). Defects in the KRAS2 gene can result in the development of juvenile myelomonocytic leukemia. This gene is also associated with non-small-cell lung adenocarcinomas (poor prognosis), ductal carcinoma of the pancreas, endometrial tumors, colorectal cancer and thyroid cancer.
C25786	NRAS_Gene	RAS_Family_Gene	NRAS Gene|N-RAS|NRAS|NRAS1|Neuroblastoma RAS Viral Oncogene Homolog	Human neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS) gene, located at 1p13.2, encodes transforming protein N-Ras. Although this gene produces two mRNA transcripts, both of these encode the same protein. Defects in the NRAS gene can cause juvenile myelomonocytic leukemia. Mutations in this gene that activate NRAS cause specific amino acid changes (codon 12, 13 or 61) in the N-ras protein. These alterations have been detected in a variety of human tumors.
C25787	Ductal_Epithelium	Epithelium	Ductal Epithelium|Duct Epithelium
C25788	C-C_Motif_Chemokine_Receptor-Like_1_Protein	Chemokine_Receptor	Chemokine (C-C Motif) Receptor-Like 1|C-C CKR-11|C-C Chemokine Receptor Type 11|CC-CKR-11|CCBP2|CCR-11|CCR11|CCRL1|CCRL1 Protein|CCX CKR|CCX-CKR|Chemokine Receptor-Like 1|PPR1|PPR1, Bovine, Homolog of|VSHK1	Chemokine (C-C Motif) Receptor-Like 1, a 45-kD glycosylated protein encoded by the CCRL1 gene, is a G protein-coupled receptor that binds chemokines of the CC subfamily, especially MCP-4, ELC (SCYA19) and TECK (SCYA25). CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines. Predominant expression of 5.0, 2.0 and 1.3kb mRNA forms exist in human heart tissue, while low-level expression of the 2.0 and 1.3kb forms in lung, pancreas and spleen and in fetal tissues. The CCRL1 gene has one intron in the 5' untranslated region. (From LocusLink, OMIM, and NCI)
C25789	C-C_Motif_Chemokine_Receptor-Like_2_Protein	Chemokine_Receptor	Chemokine (C-C Motif) Receptor-Like 2|CCRL2|CCRL2 Protein|CKRX|CRAM-A|CRAM-B|HCR	Chemokine (C-C Motif) Receptor-Like 2, encoded by the CCRL2 gene, is a seven transmembrane chemokine receptor like protein that is most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. (From LocusLink, OMIM, and NCI)
C25790	Immunoprotein_Gene	Gene	Immunoprotein Gene	Immunoprotein Genes encode proteins whose activities affect or play a role in immune system functions.
C25791	Immunoglobulin_Family_Gene	Gene	Immunoglobulin Family Gene	Immunoglobulin Family Genes encode structurally-related Immunoglobulin Family Proteins containing one, or more, 100-aa Immunoglobulin domain that includes a conserved intradomain disulfide bond and may be involved in protein-protein or protein-ligand interactions. Immunoglobulin Family members include hundreds of functionally diverse proteins, such as Immunoglobulins, the muscle kinase titin, and receptor tyrosine kinases. (NCI)
C25792	T-Cell_Surface_Glycoprotein-CD3_Epsilon_Chain	Protein_Complex_Subunit	CD3E Antigen Epsilon Polypeptide|CD3-Epsilon|CD3E|CD3E Antigen, Epsilon Polypeptide (Tit3 Complex)|CD3E Protein|T-Cell Antigen Receptor Complex, Epsilon Subunit of T3|T-Cell Surface Antigen T3/LEU-4 Epsilon Chain|T-Cell Surface Glycoprotein CD3 Epsilon Chain|T3E|TCRE	The CD3 complex mediates signal transduction. The TCR/CD3 complex of T lymphocytes consists of either a TCR Alpha/Beta or TCR Gamma/Delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled Gamma, Delta, Epsilon, Zeta, and Eta. CD3E Antigen, Epsilon Polypeptide (Tit3 Complex) is encoded by the CD3E gene. Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation. (From LocusLink, Swiss-Prot and NCI)
C25793	Immunoglobulin-Like_C2-Type_Domain	Immunoglobulin_Domain	Immunoglobulin-Like C2-Type Domain|Immunoglobulin C-2 Type Domain	The Ig constant chain domains and a single extracellular domain in each type of MHC chains are homologous and approximately 100 amino acids long, and include a conserved intra-domain disulfide bond. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. This subfamily is the C-2-type and includes glycoproteins and other unrelated proteins with immunoglobulin domains eg. carcinoembryonic antigens and fibroblast growth factor receptors. (InterPro IPR003598)
C25794	Immunoglobulin-Like_V-Type_Domain	Immunoglobulin_Domain	Immunoglobulin-Like V-Type Domain	The immunoglobulin (Ig) constant chain domains and a single extracellular domain in each type of MHC chains are homologous and approximately 100 amino acids long, and include a conserved intra-domain disulfide bond. Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. The V-type immunoglobins contain the V regions of the Ig molecule. (From InterPro IPR003596)
C25795	CD47_Antigen	Cell_Adhesion_Molecule	CD47 Antigen|Antigenic Surface Determinant Protein OA3|CD47|CD47 Antigen (Rh-Related Antigen, Integrin-Associated Signal Transducer)|CD47 Glycoprotein|IAP|Integrin Associated Protein|Integrin-Associated Protein|Leukocyte Surface Antigen CD47|MER6|OA3|Surface Antigen Identified by Monoclonal Antibody 1D8	CD47 Antigen, encoded by the CD47 gene, is a 50-kD membrane protein with an amino-terminal immunoglobulin domain and a carboxyl-terminal multiple-membrane-spanning region. CD47 Antigen is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. It is also involved in membrane permeability changes induced following virus infection. Interactions of thrombospondins with alpha4beta1 integrin and CD47 differentially modulate T cell behavior. The interaction of CD47 with SHPS-1 may contribute to the recruitment of B lymphocytes via endothelial cells under steady state conditions. CD47 Antigen is very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain. Four isoforms are produced by alternative splicing. (From LocusLink, OMIM, Swiss-Prot and NCI)
C25796	Eukaryote	Organisms	Eukaryote|Eukaryota|eukaryote|eukaryotida	Organism or cells with a nucleus separated from the cytoplasm by a two membrance nuclear envelope and compartmentalization of function into distinct cytoplasmic organelles.
C25797	E7070	Cyclin-Dependent_Kinase_Inhibitor_Drug	E7070|N-(3-Chloro-7-indoyl)-1,4-Benzenedisulfonamide	A drug that belongs to the family of drugs called sulfonamides.  It is being studied for its ability to treat cancer.
C25798	CD97_Antigen	G_Protein-Coupled_Receptor	CD97 Antigen|CD97	CD97 Antigen, encoded by the CD97 gene, is a founding member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules. CD97 Antigen is a glycoprotein present on the surface of most activated leukocytes and is a G protein-coupled receptor. This protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing generates two variants. CD97 Antigen has large N-terminal domain with five epidermal growth factor-like sequences which are differentially spliced. (From LocusLink and NCI)
C25799	ADAM11_Protein	Metalloproteinase	ADAM11 Protein|A Disintegrin and Metalloproteinase Domain 11 Protein|ADAM11|Metalloproteinase-Like, Disintegrin-Like and Cysteine-Rich Protein	Encoded by human ADAM11 Gene (ADAM Family, Peptidase M12b Family), the 769-amino acid 83 kD (precursor) type I membrane ADAM11 Protein (isoforms MDC-769 and MDC-524) is implicated in cell-cell/-matrix interactions of muscle development, neurogenesis, and fertilization. Membrane-anchored ADAM zinc metalloproteases contain disintegrin domains related to snake venom disintegrins. A putative integrin ligand, ADAM11 is a metalloprotease-like noncatalytic protein predominantly expressed in brain that contains an EGF-like domain and a conserved disintegrin domain AVN(E/D)CD motif. The precursor may be cleaved by a furin endopeptidase. ADAM11 disruptions occur in breast and ovarian cancers. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C25800	Cystatin-6	Enzyme_Inhibitor_Protein	Cystatin 6|CPI-B|CST6|Cystatin E|Cystatin M|Liver Thiol Proteinase Inhibitor|Stefin B	Encoded by human CST6 Gene, 149-amino acid 16.5 kD (precursor) Cystatin 6 is a type 2 cystatin. Cystatin superfamily proteins contain multiple cystatin-like sequences. Three inhibitory subfamilies display structural and functional similarities: type 1 stefins, type 2 cystatins, and kininogens. Some members are cysteine protease inhibitors, while others have lost or never acquired inhibitory activity. Type 2 cystatins are endogenous intracellular or extracellular cysteine proteinase inhibitors that appear to provide protective functions. (from Swiss-Prot, OMIM, and NCI)
C25801	Cell_Division_Cycle-2-Like-1_Protein	Cell_Cycle_Protein	Cell Division Cycle 2-Like 1|CDC-Related Protein Kinase p58|CDC2L1|Dual Specificity Phosphatase Cdc25A|EC 3.1.3.48|Galactosyltransferase Associated Protein Kinase|M-Phase Inducer Phosphatase 1|PITSLRE B|PITSLRE Protein Kinase Alpha|p58/GTA Protein Kinase	Cell Division Cycle 2-Like 1, encoded by the CDC2L1 gene, is a member of the p34Cdc2 serine/threonine protein kinase family. CDC2L1 is expressed ubiquitously and acts as a negative regulator of the normal cell cycle progression. It may function in regulating proliferation by phosphorylation and subsequent plasma membrane targeting of galactosyltransferase. This gene is deleted or altered frequently in neuroblastoma with amplified MYCN genes. CDC2L1 can be cleaved by caspases and play roles in cell apoptosis. A large number of the alternatively spliced variants of this gene exist. (From LocusLink, Swiss-Prot and NCI)
C25802	Chaperone_Gene	Gene	Chaperone Gene	Genes that encode cytoplasmic proteins of both prokaryotes and eukaryotes that bind to nascent or unfolded polypeptides and ensure correct folding or transport. Chaperone proteins do not covalently bind to their targets and do not form part of the finished product. Heat-shock proteins are an important sub set of chaperones. Three major families are recognised, the chaperonins (groEL and hsp60), the hsp70 family and the hsp90 family. Outside these major families are other proteins with similar functions including nucleoplasmin, secB and T-cell receptor associated protein. (On-line Medical Dictionary)
C25803	CDC37_Homolog_Protein	Chaperone	CDC37 Homolog|CDC37|CDC37 Protein|Hsp90 Chaperone Protein Kinase-Targeting Subunit|Hsp90 Co-Chaperone CDC37|p50Cdc37	CDC37 Homolog, encoded by the CDC37 gene, is a protein highly similar to Cdc 37, which is a cell division cycle control protein of Saccharomyces cerevisiae. CDC37 Homolog is a molecular chaperone with specific function in cell signal transduction. It forms complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It plays a critical role in directing the chaperone HSP90 and targeting it to the CDK4 protein kinase, thereby promoting stability of CDK4 in regulating cell division cycle. (From LocusLink and NCI)
C25804	Hydrolase_Gene	Enzyme_Gene	Hydrolase Gene|Hydrolase Family Gene
C25805	GTPase_Gene	Hydrolase_Gene	GTPase Gene	Genes (superfamily) that encode GTP hydrolyzing enzymes, which cycle between the GDP-bound inactive state and the GTP-bound active state acting as intracellular switches in various cellular pathways, such as signal transduction. (NCI)
C25806	Mouse_Urinary_Tract_Neoplasm	Mouse_Genitourinary_Neoplasms|Mouse_Urinary_Tract_Disorder	Mouse Urinary Tract Neoplasm|Urinary Tract Neoplasm
C25807	Mouse_Bladder_Neoplasm	Mouse_Urinary_Tract_Neoplasm	Mouse Bladder Neoplasm|Bladder Neoplasm
C25808	Mouse_Bladder_Paraganglioma	Mouse_Bladder_Neoplasm	Mouse Bladder Paraganglioma|Bladder Paraganglioma
C25809	Mouse_Bladder_Inflammatory_Myofibroblastic_Neoplasm	Mouse_Bladder_Neoplasm	Mouse Bladder Inflammatory Myofibroblastic Neoplasm|Bladder Inflammatory Myofibroblastic Neoplasm
C25810	Benign_Mouse_Bladder_Neoplasm	Mouse_Bladder_Neoplasm	Benign Mouse Bladder Neoplasm|Benign Bladder Neoplasm
C25811	Benign_Mouse_Bladder_Paraganglioma	Benign_Mouse_Bladder_Neoplasm	Benign Mouse Bladder Paraganglioma|Benign Bladder Paraganglioma
C25812	Mouse_Bladder_Leiomyoma	Benign_Mouse_Bladder_Neoplasm	Mouse Bladder Leiomyoma|Bladder Leiomyoma
C25813	Mouse_Bladder_Papilloma	Benign_Mouse_Bladder_Neoplasm	Mouse Bladder Papilloma|Bladder Papilloma
C25814	Malignant_Mouse_Bladder_Neoplasm	Mouse_Bladder_Neoplasm	Malignant Mouse Bladder Neoplasm|Malignant Bladder Neoplasm
C25815	Malignant_Mouse_Bladder_Paraganglioma	Malignant_Mouse_Bladder_Neoplasm	Malignant Mouse Bladder Paraganglioma|Malignant Bladder Paraganglioma
C25816	Metastatic_Neoplasm_to_the_Mouse_Urinary_Bladder	Malignant_Mouse_Bladder_Neoplasm|Mouse_Metastatic_Neoplasms	Metastatic Neoplasm to the Mouse Urinary Bladder|Metastatic Neoplasm to the Urinary Bladder
C25817	Cell_Division_Cycle-42_Protein	Cell_Cycle_Protein	Cell Division Cycle 42 Protein|CDC42|CDC42 Homolog|CDC42 Protein|Cell Division Cycle 42 (GTP Binding Protein, 25kD)|GP|GTP-Binding Protein, 25-kD	Cell Division Cycle 42, encoded by the CDC42 gene, is a small GTPase of the Rho-subfamily. This protein regulates signaling pathways that control diverse cellular functions, including cell morphology, migration, endocytosis and cell cycle progression, and the induction of malignant transformation. ACK1 is a binding partner and inhibitor of the GTP-bound form of CDC42. Interaction between GTP-CDC42 and ACK1 inhibits both the intrinsic and GAP-stimulated GTPase activity of CDC42. The product of oncogene Dbl specifically catalyzes the dissociation of GDP from CDC42. This protein regulates actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of the CDC42 gene results in the placental and brain isoforms. (From LocusLink, OMIM and NCI)
C25818	Mouse_Bladder_Lymphoma	Malignant_Mouse_Bladder_Neoplasm	Mouse Bladder Lymphoma|Bladder Lymphoma
C25819	Mouse_Bladder_Sarcoma	Malignant_Mouse_Bladder_Neoplasm|Mouse_Sarcoma	Mouse Bladder Sarcoma|Bladder Sarcoma
C25820	Mouse_Bladder_Carcinoma	Malignant_Mouse_Bladder_Neoplasm|Mouse_Carcinoma	Mouse Bladder Carcinoma|Bladder Carcinoma
C25821	Mouse_Bladder_Adenocarcinoma	Mouse_Bladder_Carcinoma	Mouse Bladder Adenocarcinoma|Bladder Adenocarcinoma
C25822	Mouse_Bladder_Squamous_Cell_Carcinoma	Mouse_Bladder_Carcinoma	Mouse Bladder Squamous Cell Carcinoma|Bladder Squamous Cell Carcinoma
C25823	Mouse_Bladder_Transitional_Cell_Carcinoma	Mouse_Bladder_Carcinoma	Mouse Bladder Transitional Cell Carcinoma|Bladder Transitional Cell Carcinoma
C25824	Chloride	Retired_Concepts	Chloride
C25825	DNA_Adduction	DNA_Damage	DNA Adduction|DNA Adduct Formation	DNA Adduction mainly involves formation of a covalent bond between a small electrophilic molecule and the DNA macromolecule. The reaction of xenobiotics with DNA appears to be one of the most important and common adduction events in the initiation of cancer.
C25826	DNA_Alkylation	DNA_Adduction	DNA Alkylation	DNA Alkylation involves the addition of alkyl groups to any of several vulnerable positions on all four of the DNA bases. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis. (Gene Ontology and NCI)
C25827	DNA_Crosslinking	DNA_Damage	DNA Crosslinking|DNA Crosslink	DNA Crosslinking involves the formation of a covalent bond between two bases on DNA. (NCI)
C25828	DNA_Interstrand_Crosslinking	DNA_Crosslinking	DNA Interstrand Crosslinking	DNA Interstrand Crosslinking involves the formation of a covalent bond between two bases on different DNA strand. (NCI)
C25829	DNA_Intrastrand_Crosslinking	DNA_Crosslinking	DNA Intrastrand Crosslinking	DNA Intrastrand Crosslinking involves the formation of a covalent bond between two bases on the same DNA strand. (NCI)
C25830	DNA_Strand_Break	DNA_Damage	DNA Strand Break	A DNA Strand Break involves one or more disruptions of the covalent linkages among phosphodeoxyribose moieties within the sugar-phosphate backbone in one or in both strands of a DNA molecule.
C25831	DNA_Single_Strand_Break	DNA_Strand_Break	DNA Single Strand Break	A DNA Single Strand Break involves one or more disruptions of the covalent linkages among phosphodeoxyribose moieties within the sugar-phosphate backbone in one strand of a DNA molecule.
C25832	DNA_Double_Strand_Break	DNA_Strand_Break	DNA Double Strand Break	A DNA Double Strand Break involves a disruption of the covalent linkages among the phosphodeoxyribose moieties within the sugar-phosphate backbone in both strands of a DNA molecule.
C25833	Abasic_Site_Formation	DNA_Damage	Abasic Site Formation|Formation of Abasic Site	Abasic Site Formation involves the creation of an apurinic or apyrimidinic site resulting from the loss of a purine or pyrimidine residue from DNA.
C25834	Formation_of_Apurinic_Site	Abasic_Site_Formation	Formation of Apurinic Site	Formation of Apurinic Site involves the creation of an apurinic site as a result of the loss of a purine residue from DNA. Purine residues are especially vulnerable to cleavage of the N-glycosylic bond between the purine residue and sugar moiety of the nucleotide, leaving in DNA a nucleotide position with no base attached.
C25835	Formation_of_Apyrimidine_Site	Abasic_Site_Formation	Formation of Apyrimidine Site	Formation of Apyrimidine Site involves the creation of an apyrimidinic site as a result of the loss of a pyrimidine residue from DNA.
C25836	Formation_of_Bistrand_Abasic_Site	Abasic_Site_Formation	Formation of Bistrand Abasic Site	Formation of Bistrand Abasic Site involves the creation of an apurinic or apyrimidinic site as a result of the loss of a purine or pyrimidine residue from both strands of DNA.
C25837	Base-Base_Mismatch	DNA_Damage	Base-Base Mismatch	Base-Base Mismatch results from mutagenic factors that induce chemical modification of DNA bases so that pairing between specific bases on complementary DNA strands is eliminated causing mispairing. (NCI)
C25838	Annamycin_Liposomal	Annamycin	Annamycin Liposomal	A liposome-encapsulated form of the antineoplastic antibiotic annamycin.  Annamycin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis.  This agent also circumvents multidrug-resistance (MDR) transporters, including p-glycoprotein.  Less toxic than annamycin, liposomal annamycin also shows improved antitumor properties compared to its parent compound. (NCI04)
C25839	Cyclin-Dependent_Kinase_Gene	Cell_Cycle_Gene	Cyclin-Dependent Kinase Gene	Cyclin-Dependent Kinase Genes encode Cyclin-Dependent Kinases, eukaryotic phosphoregulated protein kinases that physically associate with cyclins to achieve full enzymatic activity and control cell cycle progression. (NCI)
C25840	Cyclin_Gene	Cell_Cycle_Gene	Cyclin Gene	These genes encode member proteins of the highly conserved cyclin family. They are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. (From RefSeq Summary and NCI)
C25841	Cyclin-Dependent_Kinase-10	Cyclin-Dependent_Kinase	Cyclin-Dependent Kinase 10|CDK10|CDK10 Protein|Cell Division Protein Kinase 10|EC 2.7.1.-|PISSLRE Protein|Serine/Threonine-Protein Kinase PISSLRE	Cyclin-Dependent Kinase 10, encoded by the CDK10 gene, is a protein that belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members bind to cyclin to form active holoenzymes that play a pivotal role in the regulation of the eukaryotic cell cycle and are known to be essential for cell cycle progression. This kinase has been shown to play roles in cellular proliferation and its function is limited to cell cycle G2-M phase. A variety of different transcripts exist, resulting from cryptic splice sites, exon skipping, insertion of intronic sequences, and exon scrambling. The splicing of this gene is complex. At least three alternatively spliced variants of this gene exist, one of which contains multiple non-ATG translation initiation sites. (From LocusLink, OMIM and NCI)
C25842	Cyclin-Dependent_Kinase-2	Cyclin-Dependent_Kinase	Cyclin-Dependent Kinase 2|CDC2-Related Protein Kinase|CDK2|Cell Division Kinase 2|Cell Division Protein Kinase 2|EC 2.7.1.-|p33 Protein Kinase|p33(CDK2)	Cyclin-Dependent Kinase 2, encoded by the CDK2 gene, belongs to the CDKX subfamily of the Ser/Thr protein kinase family. This protein kinase is a catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. It is involved in promoting DNA synthesis and cell cycle progression. This protein associates with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). Its activity is also regulated by its protein phosphorylation. Two alternatively spliced variants and multiple transcription initiation sites of this gene exist. Its N-terminal domain interacts with cyclins and C-terminal domain interacts with CSK1. (From LocusLink, OMIM and NCI)
C25843	BARD-1_Protein	Retired_Concepts	BARD-1 Protein|BRCA1 Associated RING Domain Protein 1
C25844	CREB-Related_Protein-2	bZIP_Protein	CREB-Related Protein 2|CRE-Binding Protein-Like-2|CREBL2|cAMP Responsive Element Binding Protein-Like 2	cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurrence of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. (LocusLink)
C25845	Deleted_in_Split_Hand-Split_Foot_Protein-1	Protein_with_Unknown_or_Unclassified_Function	Deleted in Split Hand/Split Foot Protein 1|DSS1|DSS1 Protein|Deleted in Split-Hand/Split-Foot 1 Region Protein|Deleted in Split-Hand/Split-Foot Protein 1|Split Hand/Foot Deleted Protein 1|Split Hand/Foot Malformation (Ectrodactyly) Type 1	Encoded by human DSS1 Gene (DSS1/SEM1 Family), 70-amino acid 8 kD DSS1 Protein is a highly conserved acidic protein predominantly expressed in limb bud, craniofacial primordia, and skin. A human homolog of the highly conserved cytosolic SEM1 (S. cerevisiae), DSS1 may be involved in completion of the cell cycle or in a differentiation process. Containing three oligonucleotide-binding folds and a helix-turn-helix motif, DSS1 Protein directly interacts with a 90 kD C-terminal domain of BRCA2 that binds single-stranded DNA. (from Swiss-Prot, OMIM, and NCI)
C25854	CDK_Inhibitor_Gene	Retired_Concepts	CDK Inhibitor Gene
C25855	Epithelial_Discoidin_Domain_Receptor-1	Receptor_Tyrosine_Kinase	Epithelial Discoidin Domain Receptor 1|CD167A Antigen|Cell Adhesion Kinase|DDR1|Discoidin Domain Receptor|Discoidin Domain Receptor Family Member 1|Discoidin Receptor Tyrosine Kinase|Epithelial-Specific Receptor Kinase|Mammarian Carcinoma Kinase 10|NTRK4|Neuroepithelial Tyrosine Kinase|Neurotrophic Tyrosine Kinase Receptor Type 4|Protein-Tyrosine Kinase RTK 6|Receptor Tyrosine Kinase NEP|TRKE|Tyrosine Kinase DDR|Tyrosine Kinase Receptor E|Tyrosine-Protein Kinase CAK	Encoded by human DDR1 Gene (PTK Family, Insulin Receptor Subfamily), 913-amino acid 101 kD (precursor) Epithelial Discoidin Domain Receptor 1, a type I membrane protein homolog of mouse Ptk3, is largely expressed in epithelial cells of kidney, lung, gastrointestinal tract, and brain. DDR1 exhibits extracellular Discoidin I motifs; GLY/PRO-rich domains likely required for ligand or substrate interaction; a F5/8 type C domain; and a novel N-terminal region with homology to a factor VIII domain. The C-terminal catalytic domain has type II receptor tyrosine kinase motifs. Neurotrophin TRKs - TRKA, TRKB, and TRKC - regulate development and survival of specific neuronal lineages. Activated by type I-VI collagens, NTRK4 may be a non-neuronal receptor for a NGF or involved in cell-cell interactions or cell adhesion. (from Swiss-Prot Q08345 and NCI)
C25856	Dual_Specificity_Phosphatase-3	Dual-Specificity_Phosphoprotein_Phosphatase	Dual Specificity Phosphatase 3|DUSP3|Dual Specificity Protein Phosphatase 3|Dual Specificity Protein Phosphatase VHR|EC 3.1.3.16|EC 3.1.3.48|Serine/Threonine Specific Protein Phosphatase|VH1-Related Phosphatase|Vaccinia Virus Phosphatase VH1-Related	Encoded by human DUSP3 Gene, 185-amino acid 20.5 kD conserved VH1-Related Phosphatase is a non-receptor member of the dual specificity protein phosphatase subfamily (Protein-Tyrosine Phosphatase Family) that inactivates target substrates by dephosphorylating phosphotyrosine and phosphoserine/threonine residues. Negative regulators of MAPK/ERK, SAPK/JNK, and p38 members associated with cellular proliferation and differentiation, dual specificity phosphatases show different tissue distributions and subcellular locations, distinct substrate specificities for MAP kinases, and different modes of induction by extracellular stimuli. (from Swiss-Prot, OMIM, and NCI)
C25857	CDK_Inhibitor_Protein	Retired_Concepts	CDK Inhibitor Protein|CDKI Protein	CDK Inhibitor Proteins, encoded by the CDK Inhibitor genes, are a group of low molecular weight proteins that associate with cyclin-CDK complexes or CDKs alone and inhibit their activity. (From OMIM and NCI)
C25858	CDK2-Associated_Protein-1	Cyclin-Dependent_Kinase_Inhibitor	CDK2-Associated Protein 1|CDK2AP1|CDKAP1|Cyclin-Dependent Kinase 2-Associated Protein 1|DOC-1|DOC1|Deleted In Oral Cancer-1|Deleted in Oral Cancer 1	CDK2-Associated Protein 1, encoded by the CDK2AP1 gene, is a specific CDK2-associated protein that negatively regulates CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein also interacts with DNA polymerase alpha/primase and promotes the phosphorylation of the large p180 subunit, which suggests the regulatory role in DNA replication during S phase of the cell cycle. Reduction of CDK2AP1 protein expression is a frequent event in oral cancers and is a negative prognostic indicator in patients with surgically resected oral squamous cell carcinoma. Loss of CDK2AP1 protein expression may contribute to the multistep nature of oral carcinogenesis. (From LocusLink, PubMed and NCI)
C25859	Fibroblast_Growth_Factor_Receptor-4	Fibroblast_Growth_Factor_Receptor_Family	Fibroblast Growth Factor Receptor 4|FGFR-4|FGFR4|Tyrosine Kinase Related To Fibroblast Growth Factor Receptor	Encoded by human FGFR4 Gene (FGFR Family), 802-amino acid 87.9 kD (precursor) type I membrane protein Fibroblast Growth Factor Receptor 4 is a receptor tyrosine kinase with three extracellular Ig-like C2-type domains, a cytoplasmic tyrosine kinase domain, and 55% amino acid identity with FLG (FGFR1) and BEK. FGFR family amino acid sequence is highly conserved; the extracellular domain interacts with FGFs, signaling downstream cascades that influence mitogenesis and differentiation. FGFRs differ in ligand affinities and tissue distribution. Predominantly expressed in lung, FGFR4 expression is distinct from FLG, BEK, and FGFR3. Unlike FGFR1-3, FGFR4 IgIII domain C-terminal half does not vary. Although function is unknown, FGFR4 preferentially binds acidic FGF and FGF19; it does not bind to basic FGF. (from Swiss-Prot, OMIM, and NCI)
C25860	Growth_Arrest_Specific_11_Protein	Retired_Concepts	Growth Arrest Specific 11 Protein	Encoded by human GAS11 Gene, 56 kD Growth Arrest Specific 11 Protein is a ubiquitous 478-amino acid putative tumor suppressor protein. GAS11 amino acid sequence is 96% identical to the mouse homolog, expressed during growth arrest. (from Swiss-Prot, OMIM, and NCI)
C25861	Organic_Cation_Transporter-Like_2_Protein	Retired_Concepts	Organic Cation Transporter-Like 2 Protein|Imprinted Polyspecific Membrane Transporter 1|Solute Carrier Family 22, Organic Cation Transporter, Member 1-Like|Tumor-Suppressing STF 5	Encoded by human SLC22A1L Gene (Polyspecific Transporter/Multidrug Resistance Family), 424-amino acid Organic Cation Transporter-Like 2 Protein has ten transmembrane segments. Highest expression occurs in liver, heart, and kidney. The SLC22A1L organic cation transporter protein is localized on the apical surface of renal proximal tubules and appears to confer resistance/transport activity to chloroquine and quinidine-related compounds. Renal epithelial cell apical and basolateral polyspecific organic-cation transporters mediate excretion of endogenous and exogenous compounds. (from OMIM and NCI)
C25863	ADAM_Type_Metalloprotease_Domain	Protein_Domain	ADAM Type Metalloprotease Domain	ADAMs are transmembrane proteins containing both a disintegrin and a metalloprotease domain. Two thirds of the proteins with an ADAM type metalloprotease domain also contain the zinc protease pattern which locates the active site of these proteases. As they contain an adhesion domain and a protease domain, ADAM proteins potentially have both cell adhesion and protease activities. They play a role in various biological processes, including fertilization, neurogenesis, myogenesis, embryonic TGF-alpha release and inflammatory response. In ADAMTS proteins, a closely related family of proteases, the metalloprotease and disintegrin domains are flanked by thrombospondin type I (TSP1) repeat. ADAMTS proteins are soluble, extracellular matrix proteases. (From InterPro IPR001590)
C25864	Integrin_Binding	Receptor_Interaction	Integrin Binding	Integrin Binding involves a biophysical interaction between members of the Integrin family of heterodimeric receptors, that typically mediate cell-to-cell and cell-to-extracellular matrix interactions, and another biological molecule, such as a protein. Such interactions often induce alterations in signal transduction cascades that affect cell function.
C25865	Cyclin-Dependent_Kinase-3	Cyclin-Dependent_Kinase	Cyclin-Dependent Kinase 3|CDK3|Cell Division Protein Kinase 3|Cyclin-Dependent Protein Kinase 3|EC 2.7.1.-	Cyclin-Dependent Kinase 3, encoded by the CDK3 gene, belongs to the SER/THR family of protein kinases. CDK3 can phosphorylate histone H1. CDK3 is involved in the control of the cell cycle. CDK3 participates in the G1-S transition at least primarily by binding to E2F-1, E2F-2, or E2F-3 through DP-1 and by enhancing their transcriptional activities. CDK3 also interacts with cyclin E and cyclin A and Ik3-1/Cables is a novel substrate for CDK3-mediated phosphorylation by CDK3/cyclin E and CDK3/cyclin A. (From LocusLink, PubMed and NCI)
C25866	cDNA_Microarray	DNA_Microarray	cDNA Microarray	Complementary DNA(cDNA) clone inserts are robotically printed onto a glass slide and subsequently hybridized to two differentially fluorescently labeled probes. The probes are pools of cDNAs, which are generated after isolating mRNA from cells or tissues in two states that one wishes to compare. (From NHGRI, Microarray Project)
C25867	Protein_Microarray	Microarray	Protein Microarray	A molecular biology device consisting of a set of defined proteins, protein fragments, or peptides attached in a specific grid arrangement to a solid support.
C25868	G1-S_Transition	Cell_Division_Process	G1/S Transition	Processes that mark, promote, and sustain the commencement of, and commitment to continue, cellular processes involved in the S phase of the cell cycle, such as replication. (NCI)
C25869	Transmembrane_Protein_Gene	Membrane_Protein_Gene	Transmembrane Protein Gene	Transmembrane Protein Genes encode integral membrane proteins with a transmembrane region.
C25870	Transferase_Gene	Enzyme_Gene	Transferase Gene	Transferase Genes encode enzymes (Transferases) that transfer a group, such as a methyl group or a glycosyl group, from one compound (donor) to another (acceptor). (NCI)
C25871	Phosphotransferase_Gene	Transferase_Gene	Phosphotransferase Gene	A Phosphotransferase Gene encodes one of a large group of enzymes that transfer phosphate, diphosphate, nucleotidyl residues, and other groups. Many phosphotransferases catalyze the conversion of a proenzyme to an active enzyme or catalyze the transfer of phosphate groups to form triphosphates (e.g., ATP). Phosphotransferases have also been subdivided according to the acceptor group.
C25872	Kinase_Family_Gene	Phosphotransferase_Gene	Kinase Family Gene	Kinase Family Genes encode Kinase enzymes that covalently transfer the terminal, gamma phosphate group from ATP to a variety of substrates and typically play key regulatory roles in diverse cellular functions.
C25873	Serine-Threonine_Protein_Kinase_Gene	Kinase_Family_Gene	Serine/Threonine Protein Kinase Gene	Serine/Threonine Protein Kinase Genes encode enzymes (Serine/Threonine Protein Kinases) that catalyze phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors. (NCI)
C25874	Cyclin-Dependent_Kinase-Like-2_Protein	Serine-Threonine_Protein_Kinase	Cyclin-Dependent Kinase-Like 2|CDC2-Related Kinase|CDKL2|Cyclin-Dependent Kinase-Like 2 (CDC2-Related Kinase)|KKIAMRE|Serine/Threonine Protein Kinase KKIAMRE|p56 KKIAMRE Protein Kinase	Cyclin-Dependent Kinase-Like 2, encoded by the CDKL2 gene, is a member of a large family of CDC2-related serine/threonine protein kinases. CDKL2 is expressed as 2 major transcripts in adult testis and kidney, and at lower levels in adult brain and lung. A single transcript is detected in fetal brain and, at very low levels, in fetal kidney. This protein accumulates primarily in the cytoplasm, with a lower level in the nucleus. Treatment of cultured cells with epidermal growth factor causes an increase in the CDKL2 activity, but this does not require phosphorylation of the conserved MAP kinase dual phosphorylation motif present in this kinase. (From LocusLink, OMIM and NCI)
C25878	Cyclin-Dependent_Kinase_Inhibitor-2C	Cyclin-Dependent_Kinase_Inhibitor	Cyclin-Dependent Kinase Inhibitor 2C|CDK6 Inhibitor p18|CDKN2C|CDKN2C Protein|CDKN6|Cyclin-Dependent Inhibitor|Cyclin-Dependent Kinase 4 Inhibitor C|Cyclin-Dependent Kinase 6 Inhibitor|Cyclin-Dependent Kinase 6 Inhibitor p18|Cyclin-Dependent Kinase Inhibitor 2C (p18, Inhibits CDK4)|INK4C|p18|p18(INK4C)|p18-INK4C|p18-INK6	Cyclin-Dependent Kinase Inhibitor 2C, encoded by the CDKN2C gene, is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with monomeric CDK4 or CDK6, and prevent the activation of the CDK kinases, thus control cell cycle G1 progression. It inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein Rb. Two alternatively spliced transcript variants of this gene encode an identical protein. This protein contains 4 ANK repeats and is found in pancreas and heart, with the highest levels in skeletal muscle. Inactivation of CDKN2C by point mutations may contribute to deregulated growth control in certain cell lines and/or tumors. (From LocusLink, Swiss-Prot and NCI)
C25879	Cyclin-Dependent_Kinase_Inhibitor-3	Cyclin-Dependent_Kinase_Inhibitor	Cyclin-Dependent Kinase Inhibitor 3|CDI1 Protein|CDK2-Associated Dual Specificity Phosphatase|CDKN3|CDKN3 Protein|CIP2 Protein|Cyclin-Dependent Kinase Inhibitor 3 (CDK2-Associated Dual Specificity Phosphatase)|Cyclin-Dependent Kinase Interacting Protein 2|Cyclin-Dependent Kinase Interactor 1|EC 3.1.3.16|EC 3.1.3.48|KAP Protein|KAP1 Protein|Kinase-Associated Phosphatase	Cyclin-Dependent Kinase Inhibitor 3, encoded by the CDKN3 gene, is a dual-specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. This protein is a cyclin-dependent kinase inhibitor and may play a role in cell cycle regulation. It has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. Delay of cell cycle progression is dependent on CDKN3 phosphatase activity. This protein also interacts with other cyclin-dependent kinases such as CDC2 and CDK3, but not with CDK4. The CDKN3 gene is deleted, mutated, or overexpressed in several kinds of cancers. Defects in CDKN3 are found in patients with hepatocellular carcinoma (HCC). (From LocusLink, Swiss-Prot, OMIM and NCI)
C25880	Dual-Specificity_Phosphoprotein_Phosphatase	Phosphoprotein_Phosphatase	Dual-Specificity Phosphoprotein Phosphatase	Dual-specificity protein phosphatases are a subclass of protein tyrosine phosphatases that are uniquely able to hydrolyse the phosphate ester bond on both a tyrosine and a threonine or serine residue on the same protein. Dual-specificity phosphatases have a central role in the complex regulation of signalling pathways that are involved in cell stress responses, proliferation and death. (from Nat Rev Drug Discov 2002;1:961-76)
C25891	Surface_Glycoprotein_Ig_Superfamily_Member	Surface_Immunoglobulin	Surface Glycoprotein, Ig Superfamily Member|CDO|CDON|CDON Protein|Cell Adhesion Molecule-Related/Down-Regulated by Oncogenes|ORCAM	Surface Glycoprotein, Ig Superfamily Member, encoded by the human CDON gene, is a cell surface glycoprotein and a member of the immunoglobulin superfamily. Rhabdomyosarcoma is a childhood tumor of the skeletal muscle lineage in which cells display defects in both biochemical and morphological aspects of differentiation. The immunoglobulin superfamily members CDO and BOC are components of a cell surface receptor that positively regulates myogenesis in vitro. CDO and BOC may play a role in the inverse relationship between differentiation and transformation of cells in the skeletal muscle lineage. (From PubMed 12720294, LocusLink and NCI)
C25897	Cerebellar-Degeneration-Related_Antigen-1	Protein_with_Unknown_or_Unclassified_Function	Cerebellar-Degeneration-Related Antigen 1|CDR|CDR1|CDR1 Protein|CDR34|CDR62A|Cerebellar Degeneration-Related Autoantigen 1|Cerebellar Degeneration-Related Autoantigen, 34-kD|Cerebellar Degeneration-Related Protein (34kD)|Cerebellar Degeneration-Related Protein 1|Cerebellar Degeneration-Related Protein 1, 34kDa|Cerebellar Degeneration-Related Protein-1 (34kD)	Cerebellar-Degeneration-Related Antigen 1, encoded by the human CDR1 gene, is one of the target molecules recognized by autoantibodies directed against neuronal proteins in patients with paraneoplastic cerebellar degeneration, which occurs in association with small cell carcinoma of the lung, neoplasms of the breast and ovary, and Hodgkin disease. This protein contains tandem hexapeptide repeats and is expressed in brain, predominantly in normal neuroectodermal tissues and in certain malignant tumors. (From LocusLink, Swiss-Prot and NCI)
C25898	Homeobox_Protein	Transcription_Factor	Homeobox Protein|Homeobox Family Protein|Homeodomain Family Protein|Homeodomain Protein	All homeodomain proteins contain the homeodomain, a region of structural similarity present in certain prokaryotic and eukaryotic DNA-binding proteins.  Eukaryotic homeodomain proteins are encoded by homeobox genes and typically control gene expression during morphogenesis and development.
C25899	Caudal_Type_Homeobox_Transcription_Factor-2	Homeobox_Protein	Caudal Type Homeobox Transcription Factor 2|CDX-3|CDX2|CDX2 Protein|CDX3|Caudal-Type Homeo Box Transcription Factor 2|Caudal-Type Homeo Box Transcription Factor 3|Caudal-Type Homeobox Protein 2|Homeobox Protein CDX-2|Insulin-Regulating Transcription Factor CDX3	Caudal Type Homeo Box Transcription Factor 2, encoded by the human CDX2 gene, is a homeodomain protein. This nuclear protein is involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. It is important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Phosphorylation of Ser-60 of this protein mediates the transactivation capacity. CDX3 binds an A/T-rich sequence in the insulin promoter and stimulate its transcription. Increased CDX2 mRNA is associated with chronic atrophic gastritis and expression of CDX2 may trigger the initiation and development of intestinal metaplasia. In contrast, markedly reduced or absent CDX2 expression is noted in most large cell minimally differentiated carcinomas. (From LocusLink, Swiss-Prot, OMIM and NCI)
C25900	CEA_Family_Gene	Immunoglobulin_Family_Gene	CEA Family Gene|Carcinoembryonic Antigen Family Gene	Members of the CEA Family Gene encode the members of the CEA Family Protein, which consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. (From OMIM and NCI)
C25901	CEA_Family_Protein	Immunoglobulin_Family_Protein	CEA Family Protein|Carcinoembryonic Antigen Family Protein	Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. (From OMIM)
C25902	N_Domain	Protein_Domain	N Domain|N-Domain	N Domain is one of the seven predicted immunoglobulin-like domains that members of the CEA family protein have. It is extremely hydrophobic. (From OMIM and NCI)
C25903	CEACAM7_Protein	CEA_Family_Protein	Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7|CEACAM7|Carcinoembryonic Antigen CGM2|Carcinoembryonic Antigen Gene Family Member 2	Carcinoembryonic Antigen-Related Cell Adhesion Molecule 7, encoded by the human CEACAM7 gene, belongs to the carcinoembryonic antigen (CEA) family in the immunoglobulin superfamily. It contains one immunoglobulin-like V-type domain and one immunoglobulin-like C2-type domain. This protein is a potential tumor suppressor protein and strongly down-regulated in colon adenocarcinomas. Two isoforms (2a and 2b) of this protein are produced by alternative splicing. (From LocusLink, Swiss-Prot and NCI)
C25905	Protocadherin_Flamingo-2_Protein	G_Protein-Coupled_Receptor	Cadherin EGF LAG Seven-Pass G-Type Receptor 1|CELSR1|Flamingo (Drosophila) Homolog|Protocadherin Flamingo 2	Cadherin EGF LAG Seven-Pass G-Type Receptor 1, encoded by the human CELSR1 gene, is a G-Protein Coupled Receptor that may have an important role in cell/cell signaling during nervous system formation. It is an integral membrane protein with seven transmembrane domains, multiple cadherin repeats, EGF-like repeats, and laminin A G-type repeats. Two isoforms (1 and 2) may be produced by alternative splicing. The CELSR1 gene is developmentally regulated and neural-specific and the protein plays an unspecified role in early embryogenesis. (From LocusLink, Swiss-Prot, PubMed and NCI)
C25906	Serotonin-5-HT-3_Receptor	Cell_Surface_Receptor	Serotonin 5-HT-3 Receptor|5-HT-3|5-HT3R|5-Hydroxytryptamine (Serotonin) Receptor-3|5-Hydroxytryptamine 3 Receptor|5-Hydroxytryptamine Receptor 3|5-Hydroxytryptamine Receptor 3A|5-hydroxytryptamine (Serotonin) Receptor 3A|5HT3R|HTR3|HTR3 Protein|HTR3A|P46098|Serotonin-Gated Ion Channel Receptor	Serotonin 5-HT-3 Receptor, encoded by the human HTR3 gene, is one of the several different receptors for serotonin (5-hydroxytryptamine, 5-HT), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Whereas all other known serotonin receptor subtypes are G protein-coupled receptors, this receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Two isoforms, 1/5-HT3R-AS and 2/5-HT3R-AL, are produced by alternative splicing. (From OMIM, Swiss-Prot and NCI)
C25908	HTR3_Gene	Receptor_Gene	HTR3A Gene|5-HT-3|5-HT3R|5-Hydroxytryptamine (Serotonin) Receptor 3A Gene|5-Hydroxytryptamine (Serotonin) Receptor-3 Gene|5-Hydroxytryptamine 3 Receptor Gene|5-Hydroxytryptamine Receptor 3A Gene|5HT3R|HTR3|HTR3A|Serotonin 5-HT-3 Receptor Gene|Serotonin-Gated Ion Channel Receptor Gene	The HTR3 gene at 11q23.1 encodes Serotonin 5-HT-3 Receptor, one of the several different receptors for serotonin (5-hydroxytryptamine, 5-HT), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Whereas all other known serotonin receptor subtypes are G protein-coupled receptors, this receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses in neurons. It is a cation-specific, but otherwise relatively nonselective, ion channel. Two isoforms, 1/5-HT3R-AS and 2/5-HT3R-AL, are produced by alternative splicing. (From OMIM, Swiss-Prot and NCI)
C25909	_11q23_1-q23_2	Chromosome_Band	11q23.1-q23.2	A chromosome band present on 11q
C25919	CHK1_Checkpoint_Homolog_Protein	Serine-Threonine_Protein_Kinase	CHK1 Checkpoint Homolog|CHEK1|CHEK1 Protein|CHK1|Cell Cycle Checkpoint Kinase|EC 2.7.1.-|Serine/Threonine-Protein Kinase CHK1	CHK1 Checkpoint Homolog, encoded by the human CHEK1 gene, is a serine/threonine protein kinase that is required for the DNA damage checkpoint. This protein is involved in cell cycle arrest when DNA damage has occurred or when unligated DNA is present. It binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25C on serine-216 creates a binding site for 14-3-3 protein which inhibits CDC25C. This prevents activation of the CDC2-Cyclin B complex and prevents mitotic entry. This protein is expressed ubiquitously with the most abundant expression in thymus, testis, small intestine, and colon. (From LocusLink, Swiss-Prot, PubMed and NCI)
C25920	Choline_Kinase	Kinase	Choline Kinase|CHETK-Alpha|CHK|CHK Protein|CHOK|CK|CKI|CKI, Yeast, Human Complement of|EC 2.7.1.32	Choline Kinase, encoded by the human CHK gene, produces phosphocholine from choline. The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. Choline kinase is the initial enzyme in the sequence and may play a regulatory role. Choline kinase also catalyzes the phosphorylation of ethanolamine. (From LocusLink and NCI)
C25921	Muscarinic_Acetylcholine_Receptor-M4	G_Protein-Coupled_Receptor	Muscarinic Acetylcholine Receptor M4|Acetylcholine Receptor, Muscarinic, 4|CHRM4|CHRM4 Protein|Cholinergic Receptor, Muscarinic 4|Cholinergic Receptor, Muscarinic, 4|HM4	Cholinergic Receptor, Muscarinic 4, encoded by the human CHRM4 gene, is a G protein-coupled receptor. The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and postassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, mouse studies link its function to adenylyl cyclase inhibition. (From LocusLink and NCI)
C25922	DNA_Microarray	Microarray_Analysis	DNA Microarray|Gene Microarray	This term describes an experimental format in which probes representing genes that one wants to study are affixed to a substrate (e.g., a glass slide) and then exposed to target molecules (sometimes referred to as the sample). The level of hybridization between a specific probe and a target (typically indicated through fluorescence and measured through image analysis) indicates the level of the gene corresponding to that probe in a test solution. (From CHI Outlook Microarrays report)
C25928	_15q15_3	Chromosome_Band	15q15.3	A chromosome band present on 15q
C25936	Investigator	Research_Personnel	Investigator	Investigator; a scientist who devotes himself to doing research; a researcher in a clinical trial or clinical study.
C25937	Mitochondrial_Membrane	Cellular_Membrane	Mitochondrial Membrane	The double membrane structure surrounding the mitochondrion and separating it from the cell cytoplasm.  The two membranes are separated by an intermembrane space. The electron transport chain resides in the inner mitochondrial membrane.
C25938	Nuclear_Inner_Membrane	Nuclear_Membrane	Nuclear Inner Membrane|Inner Nuclear Membrane	The nuclear envelope has two membranes, each with a typical unit membrane in structure. They enclose a flattened sac and are connected at the nuclear pore sites. The inner nuclear membrane separates the perinuclear cistern of the endoplasmic reticulum from the nucleoplasm. It is attached to and supported by the lamina. A growing number of proteins that are specifically located to this membrane seem to participate in functionally organizing the nucleus. (NCI)
C25939	Oxidoreductase_Gene	Enzyme_Gene	Oxidoreductase Gene	Oxidoreductase Genes encode the class of enzymes that catalyze oxidation/reduction reactions (Oxidoreductases). The oxidized substrate is regarded as a hydrogen donor. Systematic enzyme names employ dehydrogenase wherever possible, or reductase; oxidase is only used where O2 is the acceptor.  (NCI)
C25940	Nuclear_Outer_Membrane	Nuclear_Membrane	Nuclear Outer Membrane|Outer Nuclear Membrane	The nuclear envelope has two membranes, each with the typical unit membrane structure. They enclose a flattened sac and are connected at the nuclear pore sites. The outer nuclear membrane is continuous with the rough endoplasmic reticulum (ER) and has ribosomes attached. (NCI)
C25941	Isomerase_Gene	Enzyme_Gene	Isomerase Gene	Isomerase Genes encode enzymes (Isomerases) that catalyze spatial or structural changes within a molecule by rearrangement or transfer of specific atoms or moieties to a new intramolecular location to form a new single product. The reactions do not involve a net change in the concentrations of compounds other than the substrate and the product. (NCI)
C25942	Polymerase_Gene	Transferase_Gene	Polymerase Gene	Polymerase Genes encode enzymes (Polymerases) that catalyze polymerization reactions, especially of nucleotides to polynucleotides. (NCI)
C25943	Ligase_Gene	Enzyme_Gene	Ligase Gene	Ligase Genes encode Ligases, a large major class of enzymes that catalyze the formation of a linking covalent bond between two substrate molecules, coupled with the hydrolysis of a pyrophosphate bond in ATP or a similar energy donor. (NCI)
C25948	Cytochrome-P450-2C19	Cytochrome-P450	Cytochrome P450, Family 2, Subfamily C, Polypeptide 19|CYP2C19|CYPIIC17|CYPIIC19|Cytochrome P450 2C19|Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 19|EC 1.14.14.1|Flavoprotein-Linked Monooxygenase|Mephenytoin 4'-Hydroxylase|Mephenytoin 4-Prime-Hydroxylase|Microsomal Monooxygenase|P450-11A|P450-254C|Xenobiotic Monooxygenase	This protein is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. (from LocusLink)
C25949	Hydrochloride_Salt	Salt	Hydrochloride Salt|Hydrochloride	A salt that is comprised of a hydrogen and chloride ion that can be linked to a base form of a drug making it water-soluble. (NCI)
C25951	Maleate	Organic_Chemical	Maleate|Maleates	An organic salt or ester of maleic acid that could be conjugated to free base compounds/drugs to improve the physiochemical properties including stability, solubility and dissolution rate. (NCI)
C25952	Esterase_Gene	Hydrolase_Gene	Esterase Gene	Esterase Genes encode Esterases that catalyze hydrolysis of ester bonds to produce alcohol and acid reaction products. (NCI)
C25953	Ribonuclease_Gene	Esterase_Gene	Ribonuclease Gene	Ribonuclease Genes encode (Ribo)nucleases that specifically catalyze the cleavage of phosphate ester linkages in ribonucleic acids; endoribonucleases cleave internal bonds and exoribonucleases cleave bonds at termini. (NCI)
C25954	Endoribonuclease_Gene	Ribonuclease_Gene	Endoribonuclease Gene	Endoribonuclease Genes encode hydrolytic Endoribonucleases that hydrolyse internal ribonucleotide bonds of polynucleotides to yield oligonucleotides. (NCI)
C25955	Rnase-III_Gene	Endoribonuclease_Gene	RNase III Gene|DROSHA|HSA242976|RN3|RNASE3L	Human RNase III Gene at 5p13.3 encodes 2 alternative isoforms of ubiquitous 1374-aa 159-kDa nuclear Ribonuclease III, containing a DRBM domain and 2 RNase III domains. Involved in pre-rRNA processing, RNase III endonucleolytically cleaves double-strand, not single-strand, RNA to 5'-phosphomonoester. RNase III interacts with Sp1 and a fraction is translocated to the nucleolus during S phase. (NCI)
C25956	DICER1_Gene	Rnase-III_Gene	DICER1 Gene|DCR-1 Homolog Gene|DICER Gene|DICER1|Dicer1, Dcr-1 Homolog (Drosophila) Gene|Endoribonuclease Dicer Gene|HERNA Gene|Helicase with RNase Motif Gene|Helicase-MOI Gene|Homolog of Drosophila Dicer Gene|K12H4.8-Like Gene	The human DICER1 gene at 14q32.2 encodes Endoribonuclease Dicer. This protein possesses an RNA helicase motif, containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. It is required by the RNA interference in cleaving double-stranded RNA as well as small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. The 21 to 23 bp double-stranded RNAs (siRNAs) generated target the selective destruction of homologous RNAs. (From OMIM, Swiss-Port, and NCI)
C25957	_14q32_2	Chromosome_Band	14q32.2	A chromosome band present on 14q
C25958	Double-Stranded_RNA_Binding_Domain	RNA_Recognition_Motif	Double-Stranded RNA Binding Domain|Double-Stranded RNA-Binding Domain|DsRBD Domain|dsRBD	The Double-Stranded RNA Binding Domain is found in a variety of RNA-binding proteins with different structures and exhibiting a diversity of functions. It is involved in localization of at least five different mRNAs in the early Drosophila embryo and by interferon-induced protein kinase in humans, which is part of the cellular response to dsRNA. (InterPro IPR001159)
C25959	Endoribonuclease	Ribonuclease	Endoribonuclease	A hydrolase enzyme which makes oligonucleotides and polynucleotides by hydrolysing the interior bonds of ribonucleotides. (On-line Medical Dictionary)
C25960	Rnase-III_Family_Protein	Endoribonuclease	RNase III Family Protein	Eukaryotic RNase-III Family Proteins are a group of related protein orthologs of bacterial dsRNA-specific RNase III. The basic functions of Yeast RNase III in maturation of snRNAs, snoRNAs, and rRNA appear to be widely conserved. Ubiquitous human nuclear Ribonuclease III is involved in pre-rRNA processing and endonucleolytically cleaves double-strand RNA to 5'-phosphomonoester.
C25961	Endoribonuclease_Dicer	Rnase-III_Family_Protein	Endoribonuclease Dicer|DICER1|DICER1 Protein|Dcr-1 Homolog|Dicer|EC 3.1.26.-|HERNA|Helicase with RNase Motif|Helicase-MOI|Homolog of Drosophila Dicer|K12H4.8-Like|KIAA0928	Endoribonuclease Dicer, encoded by the human DICER1 gene, possesses an RNA helicase motif, containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. It is required by the RNA interference in cleaving double-stranded RNA as well as small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. The 21 to 23 bp double-stranded RNAs (siRNAs) generated target the selective destruction of homologous RNAs. (From OMIM, Swiss-Port, and NCI)
C25962	PHAPI2_Protein	Protein_with_Unknown_or_Unclassified_Function	PHAPI2 Protein|ANP32B|APRIL Protein|Acidic (Leucine-Rich) Nuclear Phosphoprotein 32 Family Member B Protein|Acidic Protein Rich in Leucines|Proliferation Related Acidic Leucine Rich Protein PAL31|SSP29 Protein|Similar to Acidic Protein Rich in Leucines Protein	Encoded by human oncogene ANP32B Gene, 272-amino acid 31 kD PHAPI2 is similar to PHAPI.  (Swiss-Prot, LocusLink, and NCI)
C25963	Yp11_2	Chromosome_Band	Yp11.2	A chromosome band present on Yp
C25964	Small_RNA	Functional_RNA	Small RNA
C25965	Toll-Like_Receptor_Family_Gene	Receptor_Gene	Toll-Like Receptor Family Gene	Expressed in a variety of tissues, Toll-Like Receptor Family Genes encode type I transmembrane Toll-Like Receptor proteins, containing a TIR domain and multiple LRR repeats, which respond to various microbial components and mediate pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLRs typically act via MyD88 (TIR interaction) and TRAF6, activating NF-Kappa-B, cytokine production and secretion, and inflammatory response. (NCI)
C25966	MicroRNA	Small_RNA	MicroRNA|MIR|Small Temporal RNA|miRNA|micro-RNA	MicroRNA (miRNA) is a form of single-stranded RNA of typically 20-25 nucleotides long, and regulates the expression of other genes. miRNAs are transcribed from RNA genes, but are not translated into protein. A miRNA is complementary to a part of one or more messenger RNAs (mRNAs). The annealing of the miRNA to the mRNA results in a double-stranded RNA, which is not transcribed into protein. In many cases, this double-stranded RNA triggers the degradation of the mRNA transcript through a process similar to RNA interference. The miRNA prevents the protein biosynthesis of a specific gene, namely the one to whose mRNA it is complementary. (From http://www.wikipedia.org/wiki/MicroRNA and NCI)
C25967	pri-miRNA	Functional_RNA	pri-miRNA
C25968	pre-miRNA	Functional_RNA	pre-miRNA
C25969	Cytoplasmic_Protein_Gene	Gene	Cytoplasmic Protein Gene	Cytoplasmic Protein Genes encode Cytoplasmic Proteins that are typically localized in the cell interior, generally excluding the plasma membrane, mitochondria, and the nucleus. (NCI)
C25970	Lysosomal_Trafficking_Regulator	Cytoplasmic_Protein	Lysosomal Trafficking Regulator|Beige Protein|CHS1|CHS1 Protein|Chediak-Higashi Syndrome 1	Chediak-Higashi Syndrome 1, encoded by the human CHS1 gene, is Lysosomal-Trafficking Regulator Protein. This 425-kD cytoplasmic protein may sort endosomal resident proteins into late multivesicular endosome by a mechanism involving microtubules. It contains 7 WD repeats (TRP-ASP domains) and 1 beach domain, and is abundantly expressed in adult and fetal thymus, peripheral blood leukocytes, bone marrow and several regions of the adult brain. At least 3 isoforms (1, 2, 3) are produced by alternative splicing. Defects in the CHS1 gene are the cause of Chediak-Higashi Syndrome (CHS), an inherited immunodeficiency disease characterized by giant lysosomes and impaired leukocyte degranulation. (From LocusLink, Swiss-Prot, PubMed and NCI)
C25971	Non-Receptor_Tyrosine_Kinase_Gene	Kinase_Family_Gene	Non-Receptor Tyrosine Kinase Gene|Proto-Oncogene, Tyrosine-Kinase	Originally identified in the Rous sarcoma virus src transforming gene, Non-Receptor Tyrosine Kinase Genes encode Protein Tyrosine Kinases, enzymes important in control of cell growth, proliferation, differentiation, and transformation that do not function as receptors, but catalyze tyrosine phosphorylation of proteins with ATP, or other nucleotides as phosphate donors.  (NCI)
C25972	Non-Receptor_Protein_Tyrosine_Phosphatase_Gene	Protein_Tyrosine_Phosphatase_Gene	Non-Receptor Protein Tyrosine Phosphatase Gene|Cytosolic Protein Tyrosine Phosphatase Gene	Non-Receptor Protein Tyrosine Phosphatase Genes encode Non-Receptor Protein Tyrosine Phosphatases, one of the two main categories (soluble and transmembrane receptor) of enzymes that catalyze removal of a tyrosine-attached phosphate group and are important in control of cell growth, proliferation, differentiation, and transformation. Two cysteines in the catalytic domain (one absolutely required for activity) are generally conserved; other conserved residues in the vicinity are important. (NCI)
C25974	Tubulin_Binding_Agent	Antimitotic_Agent	Tubulin Binding Agent|Tubulin Binding Agents
C25975	Mitochondrial_RNA	Functional_RNA	Mitochondrial RNA|Mitochondria RNA|mtRNA
C25976	Cytokine_Signaling	Cell_Signaling_Process	Cytokine Signaling|Cytokine Signal Transduction	Cytokine Signaling involves leukocyte secretion of soluble short-range low molecular weight hormone-like intercellular messenger proteins that communicate with immune and other cells to coordinate an immune response. Cytokines primarily stimulate or inhibit activation, differentiation, proliferation, or function of phagocytes, lymphocytes, and hematopoietic stem cells in immune and inflammatory responses to bacteria, virally infected cells, and cancer cells.
C25977	Suppressor_of_Cytokine_Signaling_Family_Gene	Regulatory_Gene	Suppressor of Cytokine Signaling Family Gene|CIS Family Gene|Cytokine-Induced STAT Inhibitor Family Gene|SOCS Family Gene|SSI Family Gene|STAT-Induced STAT Inhibitor Family Gene	Suppressor of Cytokine Signaling (SOCS/SSI) Family Genes encode cytokine-specific-inducible negative feedback regulators that function downstream of cytokine receptors to attenuate signal transduction. Suppressor of Cytokine Signaling Proteins contain SH2 and SOCS BOX domains and are implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. SOCS proteins interact with multiple tyrosine kinase activated signaling proteins and inhibit cytokine signal transduction by binding to tyrosine kinase receptors. SOCS proteins regulate cell growth and survival, placental development, hematopoiesis, and T-cell allergic responses. (NCI)
C25978	Suppressor_of_Cytokine_Signaling_Family_Protein	Regulatory_Protein	Suppressor of Cytokine Signaling Family Protein|CIS Family Protein|Cytokine-Induced STAT Inhibitor Family Protein|SOCS Family Protein|SSI Family Protein|STAT-Induced STAT Inhibitor Family Protein	Encoded by Suppressor of Cytokine Signaling (SOCS/SSI) Family Genes, Suppressor of Cytokine Signaling Family Proteins are cytokine-specific-inducible negative feedback regulators that function downstream of cytokine receptors to attenuate signal transduction. Containing SH2 and SOCS BOX domains, SOCS proteins are implicated, through SOCS box binding, in ubiquitin-dependent protein degradation. SOCS proteins interact with multiple tyrosine kinase activated signaling proteins and inhibit cytokine signal transduction by binding to tyrosine kinase receptors. SOCS proteins regulate cell growth and survival, placental development, hematopoiesis, and T-cell allergic responses. (NCI)
C25979	Cytokine_Inducible_SH2-Containing_Protein	Suppressor_of_Cytokine_Signaling_Family_Protein	Cytokine Inducible SH2-Containing Protein|CIS|CIS-1 Protein|CISH|CISH Protein|Cytokine-Inducible Inhibitor of Signaling Type 1B|Cytokine-Inducible SH2-Containing Protein|G18|SOCS|Suppressor of Cytokine Signaling	Cytokine Inducible SH2-Containing Protein, encoded by the human CISH gene, is a cytokine-inducible negative regulator of cytokine signaling. This protein contains a SH2 domain and a SOCS box domain. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein is involved in the inactivation of the erythropoietin receptor. Association with EPOR may target this protein for proteolysis by the ubiquitin-dependent proteasome pathway. The CISH protein is mainly monoubiquitinated (37 kD) but may also exist in a polyubiquitinated form (45 kD). Three isoforms (1, 1B, 1C) are produced by alternative splicing, and the tissue distribution of isoforms 1 and 1B is distinct. (From LocusLink, Swiss-Prot and NCI)
C25980	SOCS_Box_Domain	Protein_Domain	SOCS Box Domain	The SOCS box is an approximately 40 amino acid region of homology invariably located at the C-terminus of the proteins in which it is present. Initially identified in the SOCS, or suppressors of cytokine signaling family of proteins, the SOCS box appears to be involved in targeting proteins for ubiquitination. The SOCS box contains a sub-domain known as the BC-box that is also found in the VHLa domain. The BC box in both SOCS box and VHLa domain facilitates binding to the Elongin BC complex. Elongin BC, in turn, interacts with the von-Hippel Lindau (VHL) tumor suppressor protein to form the core of the larger VCB E3 ubiquitin protein ligase complex. Thus, the SOCS box/VHLa domain may serve a function analogous to the structurally related F-box protein linking substrates to E3 complexes to allow ubiquitination. Five classes of N-terminal regions are found associated with the C-terminal SOCS box. (Pawson Lab, SLRI, Mount Sinai Hospital, 2003)
C25981	Membrane-Associated_Guanylate_Kinase_Family_Gene	Kinase_Family_Gene	Membrane-Associated Guanylate Kinase Family Gene|MAGUK Family Gene	Membrane-Associated Guanylate Kinase Family Genes encode MAGUK (Membrane-Associated GUanylate Kinase homolog) proteins containing DHR, SH3, and C-terminal GK-like domains. MAGUKs include Drosophila lethal(1)discs large-1 tumor suppressor protein (dlg1); mammalian Zo-1 tight junction protein; mammalian synaptic proteins that seem to interact with the cytoplasmic tail of NMDA receptor subunits (SAP90/PSD-95, CHAPSYN-110/PSD-93, SAP97/DLG1 and SAP102); 55 kD erythrocyte membrane protein (p55); C. elegans lin-2 protein; rat CASK protein; and human DLG2 and DLG3 proteins. An N-terminal ATP-binding site (P-loop) of Guanylate Kinase is not conserved in the MAGUK GK-like domain; MAGUKs do retain residues known in GK to bind GMP. (NCI)
C25982	Interleukin_Gene	Cytokine_Gene	Interleukin Gene	Interleukin Genes encode Interleukins, soluble cytokine factors produced by leukocytes and other cell types that have broad functional activities, particularly in regulating the inflammatory and immune responses of a variety of cell types. Interleukins enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules, and responses to immune and inflammatory stimuli. (NCI)
C25983	Nerve_Cell_Survival	Cell_Survival	Nerve Cell Survival	Processes that promote, sustain, and preserve nerve cell viability. (NCI)
C25984	Cardiotrophin-Like_Cytokine	Interleukin	Cardiotrophin-Like Cytokine|CLC|Neurotrophin-1/B-Cell Stimulating Factor-3	Cardiotrophin-Like Cytokine, encoded by the human CLC gene, is a cytokine of the IL-6 family. This protein stimulates nerve cell survival and B-cell proliferation. (From LocusLink and NCI)
C25985	Chemokine-Like_Receptor-1	G_Protein-Coupled_Receptor	Chemokine-Like Receptor 1|CMKLR1|CMKLR1 Protein	Chemokine-Like Receptor 1, encoded by the human CMKLR1 gene, is an orphan receptor that belongs to G Protein-Coupled Receptor. This protein may be a chemotactic peptide receptor. It is expressed during bone development and may have a function in bone metabolism. It is prominently expressed in developing osseous and cartilaginous tissue. It is also found in adult parathyroid glands. It also acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2). Two isoforms (A, B) are produced by alternative splicing. (From Swiss-Prot and NCI)
C25986	Polo-Box_Domain	Protein_Domain	Polo-Box Domain	Members of the polo subfamily of protein kinases appear to play pivotal roles in cell division and proliferation. These include mammalian Plk, Snk, and Fnk/Prk, Xenopus laevis Plx1, Drosophila melanogaster polo, Schizosaccharomyces pombe Plo1, and Saccharomyces cerevisiae Cdc5. The polo family members are characterized by the presence of a distinct region of homology in the C-terminal non-catalytic domain, termed the polo-box, which is essential for subcellular localization and mitotic functions of the polo kinases. Regulation of polo kinases may be crucial in the control of cell division. (http://tdcb.nci.nih.gov/cradaopp13.html)
C25987	_17q21_2	Chromosome_Band	17q21.2	A chromosome band present on 17q
C25988	Cytokine-Inducible_Kinase	Serine-Threonine_Protein_Kinase	Cytokine-Inducible Kinase|CNK|CNK Protein|FGF-Inducible Kinase|PLK3|Polo-Like Kinase 3|Proliferation-Related Kinase	Cytokine-Inducible Kinase, encoded by the human CNK gene, is a serine/threonine protein kinase that is involved in regulating M phase functions during the cell cycle. This membrane-associated protein may play a role in regulation of cell cycle progression and tumorigenesis. It may also be part of the signaling network controlling cellular adhesion. It is phosphorylated as cells enter mitosis and dephosphorylated as cells exit mitosis. Cytokine and cellular adhesion trigger CNK induction. CNK contains both a catalytic domain and a putative regulatory domain. It binds to the calcium/integrin-binding protein (CIB) and this interaction probably occurs via the polo-box domain. Transcripts expression appears to be down-regulated in primary lung tumor. (From LocusLink, Swiss-Prot and NCI)
C25989	Homeostasis	Metabolic_Process	Homeostasis|Physiological Homeostasis	Homeostasis is the body's maintenance of a consistent internal environment within a narrow range of variation. It is important to the continuation of life. (from http://www.usc.edu/dept/biomed/bme403/Section_1/homeostasis.html)
C25990	Connector_Enhancer_of_KSR-Like_Protein	Protein_with_Unknown_or_Unclassified_Function	Connector Enhancer of KSR-Like Protein|CNK1	Connector Enhancer of KSR-Like (Drosophila Kinase Suppressor of Ras) is encoded by the human CNK1 gene. Drosophila CNK is a necessary element in receptor tyrosine kinase pathways, possibly as a tyrosine phosphorylation target. It is involved in regulation of RAF in the MAPK pathway and may also play a role in a MAPK-independent pathway. Drosophila CNK interacts with RAF and localizes to cell junctions, required by several pathways stimulated by receptor tyrosine kinases. The function, location or structure of human CNK1 remains unknown. (From OMIM and NCI)
C25991	Signal_Transducer_and_Activator_of_Transcription_Family_Gene	Transcription_Coactivator_Gene	Signal Transducer and Activator of Transcription Family Gene|STAT Family Gene	Signal Transducer and Activator of Transcription Family Genes encode dual function cytoplasmic Signal Transducer and Activator of Transcription (STAT) proteins that are activated by tyrosine phosphorylation in response to a large number of cytokines, growth factors, and hormones. After activation they form homodimers or heterodimers that translocate to the nucleus where they either bind directly to regulatory DNA cis-elements of specific target genes or act together with other DNA-binding proteins in multiprotein transcription complexes to direct transcription. (NCI)
C25993	Ion_Channel_Protein_Gene	Gene	Ion Channel Protein Gene	Ion Channel Protein Genes encode Ion Channel Proteins that typically aggregate in membrane-associated complexes forming pores whose activities regulate the movement of ions through cellular membranes to affect cellular homeostatic conditions and/or signaling processes. (NCI)
C25994	Peptide_Hormone_Gene	Gene	Peptide Hormone Gene	Peptide Hormone Genes encode Peptide Hormones, typically synthesized as larger precursor molecules from which are derived smaller active proteins that function as hormonal signals secreted by one tissue or organ and have physiological effects on other tissues or organs.
C25995	RNA_Polymerase_Inhibitor	Enzyme_Inhibitor	RNA Polymerase Inhibitor	A class of agents that inhibit the enzyme ribonucleic acid (RNA) polymerase, which catalyzes the polymerization of an RNA strand from a DNA template. (NCI04)
C25996	Gene_with_Unknown_or_Unclassified_Function	Gene	Gene with Unknown or Unclassified Function|Unclassified Gene	Genes with Unknown or Unclassified Function encode Proteins (or RNAs) with Unknown or Unclassified Function. The cellular functions of these products are currently unidentified or unspecified. (NCI)
C25997	Adaptor_Signaling_Protein_Gene	Signaling_Pathway_Gene	Adaptor Signaling Protein Gene|Adaptor Protein Gene	A class of genes that encode signaling pathway proteins that function to mediate the coupling of multiple cell surface receptors to downstream signaling pathways in the regulation of various cellular functions. (from Oncogene 2001;20:6315-21)
C25998	_2p25_3	Chromosome_Band	2p25.3	A chromosome band present on 2p
C25999	Contactin_Associated_Protein-1	Cell_Surface_Receptor	Contactin Associated Protein 1|CNTNAP1|CNTNAP1 Protein	Contactin Associated Protein 1, encoded by the human CNTNAP1 gene, was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. This transmembrane protein includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. This protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. This gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The protein is predominantly expressed in brain and weak expression is detected in ovary, pancreas, colon, lung, heart, intestine and testis. (From LocusLink, Swiss-Prot, and NCI)
C26000	Extracellular_Matrix_Protein_Gene	Structural_Gene	Extracellular Matrix Protein Gene	Extracellular Matrix Protein Genes encode mostly fibrous Extracellular Matrix Proteins (e.g., Collagen, Elastin, Fibronectins, and Laminin), typically located in the Extracellular Matrix and commonly involved in cell attachment, cell movement, cell growth, morphogenesis, organogenesis, and tissue repair, architecture, and organization. (NCI)
C26001	Collagen_Gene	Extracellular_Matrix_Protein_Gene	Collagen Gene	Collagen Genes encode different forms of Collagen, the principle fibrous protein of connective tissue, all consisting of triple helix alpha-polypeptide chains. Collagen is differentiated from other fibrous proteins by its content of proline, hydroxyproline, and hydroxylysine; by its absence of tryptophan; and by its high content of polar groups. Hydroxyproline residues likely promote the triple helical fibrous structure of collagen. (NCI)
C26002	Collagen_IV_Alpha-3	Collagen	Collagen IV (Alpha 3)|Alpha 3 Type IV Collagen Precursor|COL4A3|COL4A3 Protein|COL4A3BP Protein|Collagen IV, Alpha-3 Polypeptide|Collagen Type IV Alpha 3 Binding Protein|Collagen of Basement Membrane, Alpha-3 Chain|Collagen, Type IV, Alpha 3 (Goodpasture Antigen)|EC 2.7.1.37|GPBP Protein|Goodpasture Antigen|STAR-Related Lipid Transfer Protein 11|STARD11 Protein|START Domain-Containing Protein 11|TUMSTATIN|Tumstatin (Human Placenta Collagen Type IV alpha3 Chain NC1 Domain)	Collagen IV (Alpha 3),encoded by the human COL4A3 gene, is a subunit of type IV collagen, the major structural component of basement membranes. In Goodpasture syndrome, autoantibodies bind to collagen in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized to the non-collagenous C-terminal domain of this protein. There are 6 alternate transcripts unique to this gene and alternate splicing is restricted to the 6 exons encoding this domain. This protein is widely expressed. Two protein isoforms (1 and 2/Delta26/GPBPD26) are produced by alternative splicing. This gene is also linked to the autosomal recessive Alport syndrome. The mutations contributing to this syndrome are also located within the exons encoding this C-terminal region. This protein phosphorylates the Goodpasture autoantigen in vitro on Ser and Thr residues. Isoform 2 seems less active. (From LocusLink, Swiss-Prot and NCI)
C26003	Protease_Gene	Hydrolase_Gene	Protease Gene	Protease Genes encode Proteases, a subclass of peptide hydrolases primarily classified by catalytic mechanism: Exopeptidases; Serine Endopeptidases; Cysteine Endopeptidases; Aspartic Endopeptidases; Metalloendopeptidases; and a group of enzymes yet to be assigned to a subclass. (NCI)
C26004	Gene_Family	Miscellaneous_Molecular_Biology_Terms	Gene Family	A set of genes coding for diverse proteins which, by virtue of their high degree of sequence similarity, are believed to have evolved from a single ancestral gene. (from On-line Medical Dictionary)
C26005	_16p12_1	Chromosome_Band	16p12.1	A chromosome band present on 16p
C26006	Trafficking_Protein_Gene	Gene	Trafficking Protein Gene	Trafficking Protein Genes encode proteins involved in various cellular sorting and transport mechanisms - such as gated transport, protein translocation, and vesicular transport - whereby cellular proteins are positioned, sorted, and directed to, sequestered in, or moved from one cellular compartment to another specific correct subcellular cellular compartment for proper function. (NCI)
C26007	Collagen_IV_Alpha-6	Collagen	Collagen IV (Alpha 6)|COL4A6|COL4A6 Protein	Collagen IV (Alpha 6), encoded by the human COL4A6 gene, is a subunit of type IV collagen, the major structural component of basement membranes. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene, alpha 5 type IV collagen, so that the gene pair shares a common promoter. Deletions in the alpha 5 gene that extend into the alpha 6 gene result in diffuse leiomyomatosis accompanying the X-linked Alport syndrome caused by the deletion in the alpha 5 gene. Two splice variants have been identified for this gene. (From LocusLink and NCI)
C26008	_17q11-q21	Chromosome_Band	17q11-q21	A chromosome band present on 17q
C26009	CC_Cytokine_Gene	Cytokine_Gene	CC Cytokine Gene	CC Cytokine Genes encode Beta Chemokines, CC-type dual-cysteine chemokines with adjacent cysteine residues in their primary sequence that act as chemoattractants for lymphocytes, monocytes, eosinophils, and basophils, but not for neutrophils. (NCI)
C26010	CXC_Cytokine_Gene	Cytokine_Gene	CXC Cytokine Gene	CXC Cytokine Genes encode Alpha Chemokines, CXC-type dual-cysteine chemokines with paired cysteine residues separated by a non-cysteine residue in their primary sequence that act as chemoattractants for neutrophils, but not for monocytes. (NCI)
C26011	Antiviral_Response	Immune_Response	Antiviral Response|Anti-Viral Response	An Antiviral Response is an induced humoral or cell-mediated reaction of the immune system to a viral antigen or infection.
C26012	Antibacterial_Response	Immune_Response	Antibacterial Response|Anti-Bacterial Response	An Antibacterial Response is an induced humoral or cell-mediated reaction of the immune system to a bacterial antigen or infection.
C26014	_16q13	Chromosome_Band	16q13	A chromosome band present on 16q
C26016	Protein_Complex_Subunit_Gene	Gene	Protein Complex Subunit Gene	A gene that encodes a protein product that is a component of a larger protein agglomeration or complex. The gene product can be an assembly component of a functional protein complex or a factor involved in stabilization.
C26017	Vitamin_Other	Vitamin	Vitamin, Other|Other Vitamins	Organic substances belonging to diverse chemical families and present in foods in minute amounts, Vitamins are essential to normal metabolism and biochemical functions, usually as coenzymes. Vitamins can be classified by solubility: lipo-soluble (vitamins A, D, E, K, F) and water-soluble (B- complex). Lack of one or more vitamins in the diet cause metabolic deficiency diseases. (NCI04)
C26018	Biological_Carcinogenesis_Non-Viral	Biological_Carcinogenesis	Biological Carcinogenesis, Non-Viral	Studies of the role of non-viral biological agents as factors or cofactors in the etiology of human and animal cancer.
C26019	Viral_Carcinogenesis	Biological_Carcinogenesis	Viral Carcinogenesis	Studies of the role of viruses as factors or cofactors in the etiology of human and animal cancer.
C26020	Terrorism_Research	Research	Terrorism Research
C26021	Bioterrorism_Research	Terrorism_Research	Bioterrorism Research	Research focused on detection of biowarfare agents and the treatment of individuals exposed to or affected by these agents.
C26022	Genetic_Testing_Research_Human	Biomedical_Research	Genetic Testing Research, Human
C26023	Iatrogenesis	Pathogenesis	Iatrogenesis	An iatrogenic condition is a state of ill health caused by medical treatment, usually due to mistakes made in treatment. (from Wikipedia)
C26025	No_SIC	Retired_Concepts	No SIC
C26026	Pediatric_Research	Research	Pediatric Research
C26027	Cytochrome_C_Oxidase_Subunit-Vic	Protein_Complex_Subunit	Cytochrome C Oxidase Subunit Vic|COX6C|COX6C Protein	Cytochrome C Oxidase Subunit Vic is encoded by the human COX6C gene. Cytochrome C Oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The nuclear-encoded subunits may be involved in the regulation and assembly of the complex. The COX VIc subunit is found in all mammalian tissues. This mitochondrial protein does not have a presequence that targets mitochondria and the mature form itself has the property of a presequence. A pseudogene COX6CP1 has been found on chromosomes 16p12. (From LocusLink and NCI)
C26028	Vaccine_Research	Biomedical_Research	Vaccine Research	Research focusing on any aspect of vaccine research, development, testing, etc.
C26030	Vaccine_Production	Vaccine_Research	Vaccine Production
C26031	Vaccine_Testing	Vaccine_Research	Vaccine Testing
C26033	Casein_Kinase_1_Alpha-1	Serine-Threonine_Protein_Kinase	Casein Kinase 1, Alpha 1|CKI-Alpha|CSNK1A1|Casein Kinase I, Alpha Isoform|Down-Regulated In Lung Cancer	Casein Kinase 1, Alpha 1, encoded by the human CSNK1A1 gene, is a serine/threonine protein kinase and has broad specificity. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. This cytoplasmic protein can phosphorylate a large number of proteins. (From LocusLink, Swiss-Prot and NCI)
C26034	Cytochrome_C_Oxidase	Protein_or_Riboprotein_Complex	Cytochrome C Oxidase
C26035	_2q33-q37	Chromosome_Band	2q33-q37	A chromosome band present on 2q
C26036	_4q21_2	Chromosome_Band	4q21.2	A chromosome band present on 4q
C26037	Food_Safety	Research	Food Safety
C26038	Unborn_Children_Conditions_Affecting	Child_Health	Conditions Affecting Unborn Children
C26039	Membrane_Protein_Gene	Gene	Membrane Protein Gene	A gene that encodes a protein that is associated with any of the cell membranes.  These may be intrinsic, transmembrane proteins or peripheral proteins.
C26040	Tumor_Suppression	Biochemical_Process	Tumor Suppression|Tumor Suppression, Molecular	Tumor Suppression involves inhibition of tumor cell growth, proliferation, malignancy, or metastasis.
C26041	Copine-VII	Membrane_Protein	Copine VII|CPNE7|CPNE7 Protein|Copine 7|MGC34192	Copine VII, encoded by the human CPNE7 gene, is a calcium-dependent membrane-binding protein. Molecular events at the interface of the cell membrane and cytoplasm may be regulated by proteins that attach to and detach from the membrane surface in response to signals. Calcium-dependent membrane-binding proteins may play such a role. Copine VII contains two N-terminal C2 domains and one von Willebrand factor A domain. It may function in membrane trafficking. Two isoforms (1 and 2) may be produced by alternative splicing. This gene has been excluded as a candidate in sporadic breast cancers with loss of heterozygosity at 16q24.3. (NCI)
C26042	C2_Domain	Protein_Domain	C2 Domain	Some isozymes of protein kinase C (PKC) contain a domain, known as C2, of about 116 amino-acid residues which is located between the two copies of the C1 domain (that bind phorbol esters and diacylglycerol) and the protein kinase catalytic domain. Regions with significant homology to the C2-domain have been found in many proteins. The C2 domain is thought to be involved in calcium-dependent phospholipid binding. Since domains related to the C2 domain are also found in proteins that do not bind calcium, other putative functions for the C2 domain such as binding to inositol-1,3,4,5-tetraphosphate have been suggested. The 3D structure of the C2 domain of synaptotagmin has been reported, the domain forms an eight-stranded sandwich constructed around a conserved 4-stranded motif, designated a C2 key. Calcium binds in a cup-shaped depression formed by the N- and C-terminal loops of the C2-key motif. (From Pfam 00168)
C26043	Von_Willebrand_Factor_A_Domain	Protein_Domain	Von Willebrand Factor A Domain	The type A domain (vWF) of the von Willebrand factor, a large multimeric glycoprotein found in blood plasma, is the prototype for a protein superfamily. Von Willebrand Factor A Domain is found in various plasma proteins and other extracellular proteins. Although the majority of VWA-containing proteins are extracellular, the most ancient ones present in all eukaryotes are all intracellular proteins involved in functions such as transcription, DNA repair, ribosomal and membrane transport and the proteasome. A common feature appears to be involvement in multiprotein complexes. Proteins that incorporate vWF domains participate in numerous biological events (e.g. cell adhesion, migration, homing, pattern formation, and signal transduction), involving interaction with a large array of ligands. A number of human diseases arise from mutations in VWA domains. (From Interpro IPR002035)
C26044	Angiogenic_Inhibition	Multicellular_Process	Angiogenic Inhibition|Angiogenesis Inhibition	Processes and mechanisms that block angiogenesis. (NCI)
C26045	Yp	Chromosome_Arm	Yp	The proximal (short) arm of chromosome Y.
C26046	Hematopoietic_Factor_Gene	Cytokine_Gene	Hematopoietic Factor Gene	Hematopoietic Factor Genes encode growth factors that promote the development of blood cells.
C26047	Colony-Stimulating_Factor_Gene	Hematopoietic_Factor_Gene	Colony-Stimulating Factor Gene	Colony-Stimulating Factor Genes encode Colony-Stimulating Factors, autocrine or paracrine glycoprotein growth factors that act synergistically on several bone marrow progenitor cells to regulate myeloid differentiation and stimulate production of blood cells. (NCI)
C26048	RGS_Family_Gene	Signaling_Pathway_Gene	RGS Family Gene|Regulators of G-Protein Signaling Gene	RGS Family Genes encode evolutionarily conserved proteins containing the RGS (Regulator of G protein Signaling) domain and generally function as negative regulators of heterotrimeric G protein signaling; several promote the GTPase activity of G protein alpha-subunits, causing it to revert to its inactive (GDP-bound) form. (OMIM)
C26049	Nucleosome_Assembly_Protein_Gene	Regulatory_Gene	Nucleosome Assembly Protein Gene|Nucleosome Assembling Protein Gene	A gene that encodes nucleosome assembly proteins, which are involved in the formation of the complex between histones and DNA in eukaryotic cells.
C26050	Sushi_Domain	Protein_Binding_Domain	Sushi Domain|Complement Control Protein (CCP) Module|SCR Repeat|Short Consensus Repeat	Sushi domains, also known as Complement control protein (CCP) modules or short consensus repeats (SCR), exist in a wide variety of complement and adhesion proteins. The structure is known for this domain, it is based on a-sandwich arrangement; one face made up of three-strands hydrogen-bonded to form a triple-stranded region at its center and the other face formed from two separate strands. (From Pfam PF00084)
C26052	Retinoic_Acid_Binding	Ligand_Binding	Retinoic Acid Binding	Retinoic Acid Binding consists of a biophysical interaction between retinoic acid (ligand) and a biological molecule, such as specific steroid receptor-like transcriptional regulator proteins containing an N-terminal modulating domain, a DNA-binding domain, and a C-terminal ligand-binding domain. The ligand-activated receptor complexes selectively bind as homodimers or heterodimers (with other steroid family receptors) to DNA response elements in target gene promoters, enhance transcriptional activity with coactivators, and mediate tissue growth and differentiation in embryogenesis, organogenesis, limb development, bone growth, and maintenance of normal epithelia.
C26053	Autoimmune_Status	Health_Status	Autoimmune Status|Autoimmunity	Autoimmune Status; the state of a person's health in regard to autoimmune disease or antibody presence.
C26054	_22q13	Chromosome_Band	22q13	A chromosome band present on 22q
C26055	Extracellular_Space	Microanatomy	Extracellular Space	Interstitial space between cells, occupied by fluid as well as amorphous and fibrous substances. (On-Line Medical Dictionary)
C26056	_9p21_3	Chromosome_Band	9p21.3	A chromosome band present on 9p
C26057	Helicase_Gene	Hydrolase_Gene	Helicase Gene	Helicase Genes encode proteins that promote unwinding of 1.) RNA during splicing and translation or 2.) duplex DNA during replication or repair by binding cooperatively to single-stranded regions of DNA or to short regions of duplex DNA that are undergoing transient opening. (NCI)
C26059	Protein_Tyrosine_Phosphatase_Gene	Protein_Phosphatase_Gene	Protein Tyrosine Phosphatase Gene|PTP Family Gene|Receptor Type PTP Gene	Protein Tyrosine Phosphatase Genes encode Protein Tyrosine Phosphatases, enzymes that specifically remove tyrosine-bound phosphate groups from many phosphoproteins, including many enzymes phosphorylated by a tyrosine kinase. Together with protein tyrosine kinases, Tyrosine Phosphatases regulate tyrosine phosphorylation and dephosphorylation in cellular signal transduction and may play a role in cell growth control and carcinogenesis. (NCI)
C26060	Alpha-Globulin	Serum_Globulin|Transport_Protein	Alpha-Globulin	A type of globulin in plasma that in electrically charged solutions exhibits greatest colloidal mobility among that of serum globulins.
C26061	_12q14_3	Chromosome_Band	12q14.3	A chromosome band present on 12q
C26062	Secretory_Granule	Secretory_Vesicle	Secretory Granule	Usually a protein, it is produced in the granular endoplasmic reticulum and the Golgi complex.  Morphologically, it is defined as a membrane-bound particle.
C26063	Secretory_Vesicle	Cytoplasmic_Inclusion	Secretory Vesicle
C26064	Protein_Serine-Threonine_Phosphatase_Gene	Protein_Phosphatase_Gene	Protein Serine/Threonine Phosphatase Gene|Serine/Threonine-Specific Protein Phosphatase Gene	Protein Serine/Threonine Phosphatase Genes encode Protein Serine/Threonine Phosphatases, a group of enzymes that specifically dephosphorylate phosphoserine and phosphothreonine residues in specific target proteins. Together with serine/threonine protein kinases, these enzymes regulate serine and threonine phosphorylation and dephosphorylation of target proteins in cellular signal transduction pathways typically involved in cell growth control. (NCI)
C26065	Ubiquitin_Protein_Ligase	Ligase	Ubiquitin Protein Ligase|Ubiquitin Protein Ligase Complex	Ubiquitin protein ligase enzymes catalyze the formation of a covalent peptide bond between the carboxy-terminal glycine of ubiquitin proteins and lysine alpha-amino group of other proteins. This typically marks proteins for either nonlysosomal proteasomal degradation or targeted transport. Ubiquitination requires sequential action of an activating enzyme, a conjugating enzyme, and a ligase.
C26066	Ubiquitin_Ligase_Gene	Ligase_Gene	Ubiquitin Ligase Gene|Ubiquitin Ligase Component Gene	Ubiquitin Ligase Genes encode eukaryotic enzymes (Ubiquitin Ligases) involved in de/ubiquitination of cellular proteins with ubiquitin through its C-terminus. Regulating the half-lives of many proteins by targeting them for degradation, ubiquitination is associated with many regulated events including protein degradation, chromatin remodeling, heat shock, cell cycle progression, differentiation, antigen presentation, retrovirus assembly, apoptosis, signal transduction, transcriptional activation, biological clocks, receptor down regulation, and endocytosis. (NCI)
C26067	_16p12_3	Chromosome_Band	16p12.3	A chromosome band present on 16p
C26068	Bone_Morphogenetic_Protein_Gene	Transforming_Growth_Factor-Beta_Family_Gene	Bone Morphogenetic Protein Gene	Bone Morphogenetic Protein Genes (TGF Beta Superfamily) encode 9 structurally related Bone Morphogenetic Proteins, non-collagenous bone-growth regulatory factors synthesized as large precursor molecules that are cleaved by proteolytic enzymes and form an active homodimer or heterodimer of two related bone morphogenetic proteins that stimulate osteogenesis. (NCI)
C26069	_2p13_2	Chromosome_Band	2p13.2	A chromosome band present on 2p
C26070	Phosphatase_Family_Gene	Hydrolase_Gene	Phosphatase Family Gene	Phosphotransferase Genes encode Phosphotransferases (Phosphatases), a large group of enzymes subdivided according to acceptor group that transfer phosphate, diphosphate, nucleotidyl residues, and other phosphomoieties. Some phosphotransferases catalyze the conversion of a proenzyme to an active enzyme; others transfer phosphate groups to form triphosphates (e.g., ATP). (NCI)
C26071	_3q22_3	Chromosome_Band	3q22.3	A chromosome band present on 3q
C26072	Phosphoinositol_Kinase_Family_Gene	Kinase_Family_Gene	Phosphoinositol Kinase Family Gene	Human Phosphoinositol Kinase Family Genes encode Phosphoinositol Kinases, enzymes that phosphorylate at various positions the inositol group in membrane-bound phosphatidylinositol, often in response to extracellular signals through G-Protein Coupled Receptors or Receptor Tyrosine Kinases. The resultant phosphoinositides act as selective membrane docking sites for signal transduction proteins with diverse PH domains. Phosphorylated inositols are released as second messengers by enzymatic cleavage of the phosphoinositides.
C26073	_7q22_2	Chromosome_Band	7q22.2	A chromosome band present on 7q
C26074	Cullin_Family_Gene	Regulatory_Gene	Cullin Family Gene	Cullin Family Genes encode Cullin Family Proteins, which are components of SCF ubiquitin ligase complexes or E3 ubiquitin ligase complexes with elongin BC complexes and other factors, involved in ubiquitination and proteasomal degradation of target cell cycle, signal transduction, and transcription proteins. Cullins may act in these multisubunit complexes as a scaffold for substrates and ubiquitin-conjugating enzymes and interact with RBX1, RNF7, CYCE, and/or TIP120A/CAND1. (NCI)
C26075	_10p11_21	Chromosome_Band	10p11.21	A chromosome band present on 10p
C26076	Arrestin_Beta-1	Signaling_Protein	Arrestin Beta 1|ARB1|ARR1|ARRB1|Arrestin Beta 1 Protein	Encoded by human Arrestin Beta 1 Gene, 418-amino acid 47 kD Beta-Arrestin 1 (Arrestin Family) regulates Beta-Adrenergic Receptor function.  Beta-Arrestins appear to bind phosphorylated Beta-Adrenergic receptors, impairing G(s) protein activation.  (Swiss-Prot and NCI)
C26077	_10q26_2	Chromosome_Band	10q26.2	A chromosome band present on 10q
C26078	Colony_Stimulating_Factor-3	Colony_Stimulating_Factor	Colony Stimulating Factor 3|CSF3|G CSF|G-CSF|Granulocyte Colony Stimulating Factor|Granulocyte Colony-Stimulating Factor|Pluripoietin	Colony Stimulating Factor 3, encoded by the CSF3 gene, is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Three transcript variants encoding three different protein isoforms have been found for this gene. (From LocusLink)
C26079	Colony_Stimulating_Factor-3_Receptor	Colony_Stimulating_Factor_Receptor	Colony Stimulating Factor 3 Receptor|CD114 Antigen|CSF3R|G-CSF Receptor|GCSF Receptor|GCSFR|Granulocyte Colony Stimulating Factor Receptor	Colony Stimulating Factor 3, encoded by the CSF3 gene, is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Three transcript variants encoding three different protein isoforms have been found for this gene. (From LocusLink)
C26080	Granulopoiesis	Leukopoiesis	Granulopoiesis	Granulopoiesis is the production or formation of differentiated granular leukocytes in the bone marrow from hematopoietic stem cells.
C26081	ATP8A2_Protein	Protein_with_Unknown_or_Unclassified_Function	ATPase, Aminophospholipid Transporter-Like, Class I, Type 8A, Member 2|ATP|ATP8A2|ATPIB|DKFZP434B1913|IB|ML-1|ML-1 Protein	ATPase, Aminophospholipid Transporter-Like, Class I, Type 8A, Member 2, encoded by the ATP8A2 gene, is an integral membrane protein has similarity to P-type ATPases, proteins that drive uphill transport of ions across membranes. Transfection of antisense constructs into a nontumorigenic cell line rendered the cells tumorigenic in nude mice. (from Swiss-Prot and OMIM)
C26082	Casein_Kinase-2_Alpha-1_Polypeptide	Serine-Threonine_Protein_Kinase	Casein Kinase 2, Alpha 1 Polypeptide|CK II|CK2 catalytic subunit alpha|CSNK2A1|Casein Kinase II, Alpha Subunit|Casein Kinase II, Alpha-1|Casein kinase II, alpha chain|EC 2.7.1.37|casein kinase II alpha 1 subunit	Casein Kinase 2, Alpha 1 Polypeptide is encoded by the CSNK2A1 gene. Casein kinase II is a serine/threonine protein kinase that phosphorylates acidic proteins such as casein. This kinase exists as a tetramer and is composed of an alpha, an alpha-prime, and two beta subunits. The alpha subunits contain the catalytic activity while the beta subunits undergo autophosphorylation. Three transcript variants encoding two different isoforms have been found for this gene. (From LocusLink)
C26083	Chondroitin_Sulfate_Proteoglycan-4	Cell_Adhesion_Molecule	Chondroitin Sulfate Proteoglycan 4|CSPG4|Melanoma-Associated Chondroitin Sulfate Proteoglycan 4	Chondroitin Sulfate Proteoglycan 4 (CSPG4), encoded by the CSPG4 gene, plays a role in stabilizing cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. CSPG4 represents an integral membrane chondroitin sulfate proteoglycan expressed by human malignant melanoma cells. (from LocusLink)
C26084	Chondroitin_Sulfate_Proteoglycan-6	Cell_Adhesion_Molecule	Chondroitin Sulfate Proteoglycan 6|Bamacan|Basement Membrane-Associated Chondroitin Proteoglycan|CSPG6|Chromosome-Asociated Plypeptide|Human Chromosome-Associated Polypeptide|Structural Maintenance Of Chromosomes 3|hCAP	Chondroitin Sulfate Proteoglycan 6 (CSPG6), encoded by the CSPG6 gene, is an abundant secreted chondroitin sulfate proteoglycan in basement membranes and an intracellular protein. CSPG6 is involved in chromosome cohesion during cell cycle and in DNA repair as a central component of the cohesin complex, which is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis and in chromosome movement. (from LocusLink)
C26085	C-Terminal_Binding_Protein-2	Transcription_Repressor_Corepressor	C-Terminal Binding Protein 2|CTBP2|Ribeye	C-Terminal Binding Protein 2, one of the two distinct proteins encoded by the CTBP2 gene, is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. (from LocusLink)
C26086	Cardiotrophin-1	Cytokine	Cardiotrophin 1|CTF1|Cardiophin 1	Cardiotrophin 1 was cloned via its ability to potently induce cardiac myocyte hypertrophy in vitro.  It is a member of the family of cytokines that includes leukemia inhibitory factor (LIF), ciliary neurotrophic factor (CNTF), oncostatin M (OSM), and interleukin 6 (IL6). Several members of this family that are known to signal through the transmembrane protein gp130 stimulate cardiac myocyte hypertrophy, like cardiotrophin 1, suggesting that the gp130 signaling pathway may play a role in cardiac hypertrophy. (from OMIM)
C26087	Cathepsin-Z	Cathepsin	Cathepsin Z|CTSZ|Cathepsin P|Cathepsin X|Cathepsin X Precursor|Cathepsin Z Precursor|Cathepsin Z Preproprotein|EC 3.4.22.-|Preprocathepsin P	Cathepsin Z, encoded by the CTSZ Gene, is a lysosomal cysteine proteinase. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. Cathepsin Z has also been known as cathepsin X and cathepsin P. The CTSZ gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. (From LocusLink and NCI)
C26088	Cullin-1_Protein	Cullin_Family_Protein	Cullin 1|CUL-1|CUL1|Cullin 1 Protein|Cullin Homolog 1	Cullin 1, encoded by the CUL1 gene, is an essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, Cullin 1 serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. It may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. (from Swiss-Prot)
C26089	Arginine_Vasopressin-Neurophysin-II_Preproprotein	Signaling_Protein	Arginine Vasopressin-Neurophysin II Preproprotein|ADH|ARVP|AVP|AVP-NPII|AVRP|Prepro-Arginine-Vasopressin-Neurophysin II|VP|Vasopressin-Neurophysin II-Copeptin	This protein is a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin II and a glycopeptide, copeptin. Arginine vasopressin is a posterior pituitary hormone which is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin II, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. (from LocusLink)
C26090	Cullin-2_Protein	Cullin_Family_Protein	Cullin 2|CUL2|Cullin 2 Protein|Cullin Homolog 2	Encoded by human CUL2 Gene (Cullin Family), 745-aa 87-kDa Cullin 2 is a component of multisubunit E3 ubiquitin ligase complexes with elongin BC complexes and other factors. Involved in the third step of ubiquitin conjugation, CUL2 may act as scaffold that positions substrate and the ubiquitin-conjugating enzyme. CUL2 interacts with RBX1, RNF7, and TIP120A/CAND1. (NCI)
C26091	Cullin_Family_Protein	Regulatory_Protein	Cullin Family Protein	Encoded by Cullin Family Genes, Cullin Family Proteins are components of SCF ubiquitin ligase complexes or E3 ubiquitin ligase complexes with elongin BC complexes and other factors, involved in ubiquitination and proteasomal degradation of target cell cycle, signal transduction, and transcription proteins. Cullins may act in these multisubunit complexes as a scaffold for substrates and ubiquitin-conjugating enzymes and interact with RBX1, RNF7, CYCE, and/or TIP120A/CAND1. (NCI)
C26092	Cullin-3_Protein	Cullin_Family_Protein	Cullin 3|CUL3|Cullin Homolog 3|KIAA0617	Widely expressed by human CUL3 Gene (Cullin Family), 768-aa 89-kDa neddylated nuclear and Golgi-associated Cullin 3 is involved in ubiquitination of cyclin E and perhaps cyclin D1 in regulation of G1/S transition. CUL3 interacts with RBX1, RNF7, CYCE and TIP120A/CAND1. (NCI)
C26093	Cullin-4A_Protein	Cullin_Family_Protein	Cullin 4A|CUL-4A|CUL4A|Cullin Homolog 4A	Encoded by human CUL4a Gene (Cullin Family), 659-aa 77-kDa neddylated Cullin 4 is involved in the third step of ubiquitin conjugation and proteasomal degradation of target proteins. CUL4a interacts with RBX1, RNF7 and TIP120A/CAND1. (NCI)
C26095	Cullin-5_Protein	Cullin_Family_Protein	Cullin 5|CUL-5|CUL5|Cullin 5 Protein|Cullin Homolog 5|Cullin-5|VACM-1|Vasopressin-Activated Calcium-Mobilizing Receptor|Vasopressin-Activated Calcium-Mobilizing Receptor 1|Vasopressin-Activated Calcium-Mobilizing Receptor-1	Encoded by human CUL5 Gene (Cullin Family), 780-aa 91-kDa neddylated Cullin 5 is a component of E3 ubiquitin ligase complexes with elongin BC complex and diverse other factors, involved in the third step of ubiquitin conjugation and proteasomal degradation of target proteins. CUL5 interacts with RBX1 and RNF7. Evidence suggests that CUL5 may also form a cell surface vasopressin receptor. (NCI)
C26096	Arginine_Vasopressin_Receptor-1A	Vasopressin_Receptor	Arginine Vasopressin Receptor 1A|AVPR1A|Antidiuretic Hormone Receptor 1A|SCCL Vasopressin Subtype 1a Receptor|V1a Vasopressin Receptor	This protein acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1B, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor mediates cell contraction and proliferation, platelet aggregation, release of coagulation factor and glycogenolysis.
C26097	Arginine_Vasopressin_Receptor-1B	Vasopressin_Receptor	Arginine Vasopressin Receptor 1B|AVPR1B|Antidiuretic Hormone Receptor 1B|Arginine Vasopressin Receptor 3|Pituitary Vasopressin Receptor 3|Vasopressin V1B Receptor	This protein acts as receptor for arginine vasopressin. This receptor belongs to the subfamily of G-protein coupled receptors which includes AVPR1A, V2R and OXT receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system. The receptor is primarily located in the anterior pituitary, where it stimulates ACTH release. It is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoids responsible for the ectopic ACTH syndrome. A spliced antisense transcript of this gene has been reported but its function is not known.
C26100	Arginine_Vasopressin_Receptor-2	Vasopressin_Receptor	Arginine Vasopressin Receptor 2|AVPR2	Arginine Vasopressin Receptor 2 is also known as the V2 receptor. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts, where its primary property is to respond to the pituitary hormone arginine vasopressin (AVP) by stimulating mechanisms that concentrate the urine and maintain water homeostasis in the organism. When the function of this gene is lost, the disease Nephrogenic Diabetes Insipidus (NDI) results. AVPR2 expression has also been described in fetal lung tissue and lung cancer associated with alternative splicing. (LocusLink)
C26101	Bradykinin_Receptor-B2	G_Protein-Coupled_Receptor	Bradykinin Receptor B2|B2R|BDKRB2|BK-2|BK2|BKR2|BRB2	Bradykinin Receptor B2, encoded by the BDKRB2 gene, is a receptor for bradykinin. The 9 aa bradykinin peptide elicits many responses including vasodilation, edema, smooth muscle spasm and pain fiber stimulation. This receptor associates with G proteins that stimulate a phosphatidylinositol-calcium second messenger system. Alternate start codons result in two isoforms of the protein. (from LocusLink)
C26102	Burkitt_Lymphoma_Receptor-1_Protein	Chemokine_Receptor	Burkitt Lymphoma Receptor 1 Protein|BLR1|Monocyte-Derived Receptor 15	A cytokine receptor that binds to BLC. Burkitt lymphoma receptor 1 exerts possibly a regulatory function in Burkitt lymphoma lymphomagenesis and/or B-cell differentiation. It is a potential candidate for cell-cell interaction, and activation of mature B- lymphocytes in lymphatic tissues. (Swissprot)
C26103	C_Motif_Chemokine_Receptor-1	Chemokine_Receptor	Chemokine (C Motif) Receptor 1|Chemokine, C Motif, Receptor 1|G Protein-Coupled Receptor 5|Lymphotactin Receptor|XC Chemokine Receptor 1|XCR1	Encoded by human XCR1 Gene (GPCR Family 1), Chemokine (C Motif) XC Receptor 1 is a 333-amino acid 38.5 kD seven transmembrane protein most closely related to RBS11 and MIP1-alpha/RANTES receptor. Strong expression of the receptor for chemokines XCL1 (SCYC1) and XCL2 (SCYC2) occurs in placenta, spleen, and thymus. Cells expressing GPR5 mobilize intracellular calcium and migrate in response to SCYC1 and SCYC2. Migration is suppressed by pertussis toxin, indicating that the receptor is coupled to a G-alpha protein.  (OMIM, Swiss-Prot, LocusLink, and NCI)
C26104	Colony_Stimulating_Factor-2_Receptor_Beta	Colony_Stimulating_Factor_Receptor	Colony Stimulating Factor 2 Receptor, Beta|CDw131 Antigen|CSF2RB|Colony Stimulating Factor 2 Receptor, Beta, Low-Affinity|Cytokine Receptor Common Beta Chain|GM-CSF/IL-3/IL-5 Receptor Common Beta-Chain|Granulocyte-Macrophage Colony-Stimulating Factor Receptor, Beta|Interleukin 3 Receptor, Beta|Interleukin 3 Receptor/Granulocyte-Macrophage Colony Stimulating Factor 3 Receptor, Beta (High Affinity)|Interleukin 5 Receptor, Beta	Colony Stimulating Factor 2 Receptor, Beta, Low-Affinity (CSF2RB), encoded by the CSF2RB gene, is a common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defective CSF2RB has been reported to be associated with protein alveolar proteinosis. (From LocusLink)
C26105	Coagulation_Factor-II_Receptor	G_Protein-Coupled_Receptor	Coagulation Factor II Receptor|F2R|Protease-Activated Receptor 1|Thrombin Receptor	Expressed in platelets and vascular endothelia by human F2R Gene (GPCR1 Family), 425-aa 47-kDa (precursor) Coagulation Factor II Receptor is a 7-transmembrane G-protein coupled high affinity activated thrombin receptor that stimulates phosphoinositide hydrolysis in the cellular thrombotic response. F2R appears to play a role in platelet activation and vascular development. Receptor phosphorylation probably mediates desensitization prior to uncoupling and internalization. Activated protein C uses EPCR as a coreceptor for cleavage of Coagulation Factor II Receptor on endothelia. Proteolytic cleavage of F2R generates a new N-terminus that functions as a tethered ligand. (NCI)
C26106	Fas-Associated_Via_Death_Domain_Protein	Adaptor_Signaling_Protein	Fas-Associated Via Death Domain|FADD|FAS-Associated Protein with A Death Domain|MGC8528|MORT1	Acts as an adaptor protein, interacting with FAS or TNFR-2. The death domain of these receptors binds to the corresponding domain of FADD, which in turn recruits the zymogen form of the death protease FLICE, activating a protease cascade which results in apoptosis.
C26107	Deleted_in_Malignant_Brain_Tumors-1_Protein	Receptor	Deleted in Malignant Brain Tumors 1|DMBT1|DMBT1 Protein|DMBT1/8kD.2 Protein|Glycoprotein 340|Surfactant, Pulmonary-Associated Protein D-Binding Protein	Deleted in Malignant Brain Tumors 1, encoded by the human DMBT1 gene, is a member of the scavenger-receptor superfamily and likely a truncated form of a receptor for SFTPD. This 340 kD protein is a glycoprotein containing multiple scavenger receptor cysteine-rich (SRCR) domains separated by SRCR-interspersed domains (SID). Binding between GP340 and SFTPD is a protein-protein interaction and the binding to GP340 takes place via the carbohydrate recognition domain of SFTPD. DMBT1 is expressed with transcripts of 6.0, 7.5, and 8.0 kb in fetal lung and with one transcript of 8.0 kb in adult lung, although the 7.5 kb transcript has not been characterized. Transcript variant 2 (8.0 kb) binds surfactant protein D independently of carbohydrate recognition. This indicates that DMBT1 may play a role in the interaction of tumor cells and the immune system. (From LocusLink, OMIM and NCI)
C26108	Scavenger_Receptor_Cysteine-Rich_Domain	Protein_Domain	Scavenger Receptor Cysteine-Rich Domain|SRCR Domain
C26109	SRCR-Interspersed_Domain	Protein_Domain	SRCR-Interspersed Domain|SID Domain
C26110	Methyltransferase_Gene	Transferase_Gene	Methyltransferase Gene	Methyltransferase Genes encode Methyltransferases, a subclass of transferase class enzymes that catalyze the transfer of a methyl group from one compound to another. (NCI)
C26111	ADD-Type_Zinc-Finger	Zinc_Finger_Domain	ADD-Type Zinc-Finger
C26112	DNA_Methyltransferase-3B	DNA_Modification_Methylase	DNA Methyltransferase 3B|DNA (Cytosine-5-)-Methyltransferase 3 Beta|DNA MTase HsaIIIB|DNA Methyltransferase HsaIIIB|DNMT3B|DNMT3B Protein|EC 2.1.1.37|ICF|M.HsaIIIB	DNA Methyltransferase 3B, encoded by the human DNMT3B gene, is required for genome wide de novo methylation and is essential for development. This nuclear protein interacts with UBL1 and UBE2I9. Six isoforms (1, 2, 3, 4, 5 and 6) are produced by alternative splicing but isoforms 4 and 5 are probably not functional due to the deletion of two conserved methyltransferase motifs. Isoform 1 is expressed in all tissues except brain, skeletal muscle and PBMC, 3 is ubiquitous, 4 is expressed in all tissues except brain, skeletal muscle, lung and prostate and 5 is detectable only in testis and at very low level in brain and prostate. Defects in DNMT3B are a cause of immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. ICF is biochemically characterized by hypomethylation of CpG sites in some regions of heterochromatin. (From LocusLink, Swiss-Prot and NCI)
C26113	DOC-1_Related_Protein	Protein_with_Unknown_or_Unclassified_Function	Tumor Suppressor Deleted in Oral Cancer-Related 1|DOC-1R|DOC-1R Protein	Ubiquitous 126-aa 13-kDa Tumor Suppressor Deleted In Oral Cancer-Related 1 protein is encoded by human DOC-1R Gene (DOC1 Family). (NCI)
C26114	Cell_Surface_Extension	Cell_Movement_Process	Cell Surface Extension	Cell Surface Extension is a coordinated cellular process involving the cell membrane, cytoskeleton, subcortical elements, and other subcellular structures that generates a localized outgrowth of a cell.
C26115	Phagocytosis	Cellular_Process	Phagocytosis	Endocytosis of particulate material, such as microorganisms or cell fragments, into membranous phagosomes that fuse with lysosomes and result in digestion of the ingested material. (NCI)
C26116	Dedicator_of_Cyto-Kinesis-1_Protein	Regulatory_Protein	Dedicator of Cyto-Kinesis 1|Ced5, C. Elegans, Homolog of|DOCK, 180-kD|DOCK1|DOCK180|Downstream of CRK-Binding Protein, 180-kD	Dedicator of Cyto-Kinesis 1, encoded by the human DOCK1 gene, binds to the SH3 domain of CRK protein and may be involved in integrin signaling. It may regulate cell surface extension. During programmed cell death (apoptosis), cell corpses are rapidly engulfed. This engulfment process involves the recognition and subsequent phagocytosis of cell corpses by engulfing cells. This protein may function in the cell surface extension of an engulfing cell around a dying cell during apoptosis. (From LocusLink, OMIM and NCI)
C26117	Docking_Protein-1	Signaling_Protein	Docking Protein 1|DOK1|Docking Protein 1 (Downstream of Tyrosine Kinase 1)|Docking Protein 1, 62kD (Downstream of Tyrosine Kinase 1)|Docking Protein, 62-kD|Downstream of Trosine Knase 1|p62(DOK)|p62DOK|pp62	Docking Protein 1, encoded by the human DOK1 gene, interacts with receptor tyrosine kinases and mediates particular biological responses. This 62-kD protein is associated with p120 Ras-GAP and this association is correlated with its tyrosine phosphorylation. It is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. It plays an important role in mitogenic signaling and its aberrant phosphorylation may contribute to the progression of different human diseases. It is phosphorylated by the insulin receptor kinase, resulting in the negative regulation of the insulin signaling pathway. (From LocusLink, Swiss-Prot, OMIM and NCI)
C26118	PTB_Domain	Protein_Binding_Domain	PTB Domain|Phosphotyrosine Binding Domain	Phosphotyrosine binding (PTB) domains are 100-150 residue modules that commonly bind Asn-Pro-X-Tyr motifs. The PTB domains of the docking proteins Shc and IRS-1 require ligand phosphorylation on the tyrosine residue (NPXpY) for binding. More N-terminal sequences are also required for high affinity binding and conferring specificity. The peptide binds as a b-strand to an anti-parallel b-sheet, while the NPXpY motif makes a turn, positioning the pY for recognition by basic residues. The PTB domains of proteins such as X11, Dab, Fe65 and Numb apparently recognize NPXY or related peptide motifs, but are not dependent on ligand phosphorylation. In addition, the Numb PTB domain can bind an unrelated peptide that forms a helical turn.(www.mshri.on.ca/pawson)
C26119	DOK_Domain	Protein_Domain	DOK Domain
C26120	Dopamine_Receptor-D1	Dopamine_Receptor	Dopamine Receptor D1|DRD1|DRD1 Protein	Dopamine Receptor D1, encoded by the human DRD1 gene, is the most abundant dopamine receptor in the central nervous system. This G-protein coupled receptor stimulates adenylyl cyclase and activates cyclic AMP-dependent protein kinases. It regulates neuronal growth and development, mediates some behavioral responses, and modulates dopamine receptor D2-mediated events. Alternate transcription initiation sites result in two transcript variants of this gene. (From LocusLink and NCI)
C26121	Dopamine_Receptor-D4	Dopamine_Receptor	Dopamine Receptor D4|D(2C) Dopamine Receptor|D(4) Dopamine Receptor|D4DR|DRD4|DRD4 Protein	Dopamine Receptor D4, encoded by the human DRD4 gene, is a G-protein coupled receptor that inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. DRD4 is one of the most variable human genes known. Most of this diversity is the result of length and single-nucleotide polymorphism (SNP) variation in a 48-bp VNTR in exon 3, which encodes the third intracellular loop of this dopamine receptor. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. (From LocusLink, OMIM and NCI)
C26122	Dopamine_Receptor-D5	Dopamine_Receptor	Dopamine Receptor D5|D(1B) Dopamine Receptor|D(5) Dopamine Receptor|D1Beta Dopamine Receptor|DBDR|DRD1B|DRD1L2|DRD5|DRD5 Protein|Dopamine Receptor D1B	Dopamine Receptor D5, encoded by the human DRD5 gene, is a G-protein coupled receptor which stimulates adenylyl cyclase. This receptor is expressed in neurons in the limbic regions of the brain. It has a 10-fold higher affinity for dopamine than the D1 subtype. This receptor complexes selectively with GABA-A ligand-gated channel through the direct binding of its carboxy-terminal domain with the second intracellular loop of the GABA-A gamma-2 (short) receptor subunit. This physical association enables mutual inhibitory functional interactions between these receptor systems. Pseudogenes related to this gene reside on chromosomes 1 and 2. Defects in DRD5 are a cause of blepharospasm, a primary focal dystonia affecting the orbicularis oculi muscles, usually beginning in middle age. (From LocusLink, Swiss-Prot, OMIM and NCI)
C26123	Diphtheria_Toxin_Receptor	Epidermal_Growth_Factor_Superfamily_Protein	Diphtheria Toxin Receptor|DT-R|DTR|DTR Protein|DTS|Diphtheria Toxin Sensitivity|HB-EGF|HBEGF|HEGFL|Heparin-Binding EGF-Like Growth Factor	Diphtheria Toxin Receptor, encoded by the human DTR gene, is a heparin-binding EGF-like growth factor. It is mitogenic for fibroblasts and smooth muscle and may be involved in macrophage-mediated cellular proliferation. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. This mature type I membrane protein is released into the extracellular space and probably binds to a receptor. (From LocusLink, Swiss-Prot and NCI)
C26124	Heparin_Binding	Protein-Carbohydrate_Interaction	Heparin Binding	Heparin Binding involves a biophysical interaction between a biological molecule, such as a protein, and heparin, a sulfated glycosaminoglycan of mixed polysaccharide nature, varying in molecular weight, and released by mast cells and basophils in many tissues. Lipotrophic by activation of lipoprotein lipase, anticoagulant heparin also binds to and enhances antithrombin III activity and inhibits several coagulation factors.
C26125	Fibroblast_Growth_Factor-10	Fibroblast_Growth_Factor	Fibroblast Growth Factor 10|FGF10|Keratinocyte Growth Factor 2	Encoded by human FGF10 Gene (FGF Family), secreted 208-aa 23-kDa (precursor) Fibroblast Growth Factor 10 contains 2 putative N-glycosylation sites, a heparin binding domain, and several putative phosphorylation sites and is involved in epidermal brain, lung, and limb bud morphogenesis. Most similar to FGF7, FGF10 is mitogenic in the lung and for keratinizing epidermal cells. FGF10 also appears to be involved tissue repair/wound healing. (NCI)
C26126	Fibroblast_Growth_Factor-20	Fibroblast_Growth_Factor	Fibroblast Growth Factor 20|FGF20	Expressed in brain by human FGF20 Gene (FGF Family), 211-aa 23.5-kDa Fibroblast Growth Factor 20 contains a strong hydrophobic region in its FGF core domain and a weak hydrophobic N terminal region. FGF20 may enhance the survival of midbrain dopaminergic neurons. (NCI)
C26127	Fibroblast_Growth_Factor-21	Fibroblast_Growth_Factor	Fibroblast Growth Factor 21|FGF21	Fibroblast Growth Factor 21 (209-aa 22-kDa precursor) is encoded by human FGF21 Gene (FGF Family). FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. (NCI)
C26128	Fibroblast_Growth_Factor-8	Fibroblast_Growth_Factor	Fibroblast Growth Factor 8|FGF8	Encoded by human FG8F Gene (FGF Family), alternative isoforms FGF-8A, FGF-8B, FGF-8E, and FGF-8F of secreted autocrine androgen-induced Fibroblast Growth Factor 8 may be involved in angiogenesis and/or act as an embryonic epithelial factor in midbrain and limb development, in organogenesis, in gastrulation, and in left-right axis determination. Additional isoforms may exist. (NCI)
C26129	Fibroblast_Growth_Factor_Receptor-3	Fibroblast_Growth_Factor_Receptor_Family	Fibroblast Growth Factor Receptor 3|EC 2.7.1.112|FGFR3|Hydroxyaryl-Protein Kinase|Tyrosine Kinase JTK4	Expressed in brain, kidney, testis, and widely in fetal tissues by human FGFR3 Gene (FGFR Family), 3 alternative isoforms of highly conserved type I membrane protein Fibroblast Growth Factor Receptor 3, consisting of an acidic- and basic-FGF binding extracellular region (containing 3 Ig C2-type domains), a transmembrane segment, and a cytoplasmic tyrosine kinase domain, activate downstream signal cascades involved in mitogenesis and differentiation, as well as bone development and maintenance. FGFR3 defects cause achondroplasia, crouzon syndrome, thanatophoric dysplasia, coronal synostosis, hypochondroplasia, bladder and cervix cancers. (NCI)
C26130	Endometrial_Bleeding_Associated_Factor	Transforming_Growth_Factor-Beta	Endometrial Bleeding Associated Factor|EBAF|Endometrial Bleeding-Associated Factor|LEFTA|LEFTY 1, Mouse, Homolog of|LEFTY A|LEFTY1|LEFTY2|LEFTYA|Left-Right Determination Factor A|Lefty-A Protein|MGC46222|TGF-Beta 4|TGFB4|Transforming Growth Factor Beta 4|Transforming Growth Factor, Beta-4|Transforming Growth Factor, Beta-4 (Endometrial Bleeding-Associated Factor; LEFTY A)	Endometrial Bleeding Associated Factor, encoded by the human EBAF gene, is a member of the TGF-beta family of proteins. This protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. It is transiently expressed before and during menstrual bleeding and may also play a role in endometrial bleeding. Mutations in this gene have been associated with left-right axis malformations, particularly in the heart and lungs. Some types of infertility have been associated with dysregulated expression of this gene in the endometrium. Alternative processing of this protein can yield three different products. (From LocusLink, Swiss-Prot and NCI)
C26131	Growth_Factor_Receptor_Gene	Receptor_Gene	Growth Factor Receptor Gene|Proto-Oncogene, Growth Factor Receptor	A class of genes that encode cell surface proteins that bind to extracellular polypeptide molecules triggering intracellular signaling pathways that activate various cellular responses such as cell proliferation and/or differentiation. (NCI)
C26132	Fibroblast_Growth_Factor_Receptor-Like-1_Protein	Fibroblast_Growth_Factor_Receptor_Family	Fibroblast Growth Factor Receptor-Like 1|FGFRL1	Encoded by human FGFRL1 Gene (FGFR Family), at 504-aa 54.6-kDa conserved Fibroblast Growth Factor Receptor-Like 1 consists of an extracellular region (containing 3 Ig-like domains), a hydrophobic transmembrane segment, and a cytoplasmic tail lacking a tyrosine kinase domain. This protein may interact with other family members and inhibit growth factor signaling. (NCI)
C26133	Fas-Activated_Serine-Threonine_Kinase	Serine-Threonine_Protein_Kinase	Fas-Activated Serine/Threonine Kinase|FAST Kinase|FASTK	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas by human FASTK Gene (Ser/Thr PK Family), 3 alternative isoforms of 549-aa 61-kD Fas-Activated Serine/Threonine Kinase are rapidly activated during Fas-mediated apoptosis as serine/threonine dephosphorylated FASTK, which phosphorylates TIA1, a key apoptosis-promoting nuclear RNA-binding protein. (NCI)
C26134	Glomulin	Protein_with_Unknown_or_Unclassified_Function	Glomulin|FAP48|FK506-Binding Protein-Associated Protein|FK506-Binding Protein-Associated Protein 48 kDa|FKBP-Associated Protein|FKBP-Associated Protein 48 kDa|FKBP-Associated Protein FAP48|FKBP-Associated Protein FAP68	Encoded by human GLMN Gene, two alternative isoforms of ubiquitous monomeric Glomulin interact with immunophilins FKBP59, FKBPP52, and FKBP12 that bind the macrolide immunosuppressants FK506 and rapamycin. A possible membrane anchoring protein, Glomulin may couple hepatocyte growth factor receptor signaling to the p70 S6 protein kinase pathway. (NCI)
C26135	DNA_Repair_Protein-XRCC9	DNA_Repair_Protein	DNA Repair Protein XRCC9|FANCG|Fanconi Anemia Complementation Group G|Fanconi Anemia Group G Protein|X-Ray Repair Complementing Defective Repair In Chinese Hamster Cells 9	Expressed in testis, thymus, and lymphoblasts by human FANCG Gene, 622-aa 68.5-kD DNA Repair Protein XRCC9 contains an N-terminal leucine-zipper motif and belongs to a multisubunit nuclear protein complex with PHF9, FANCA, FANCC, FANCE, and FANCF. Implicated in interstrand DNA cross-link repair and in maintenance of normal chromosome stability, FANCG may operate in postreplication repair or in a cell cycle checkpoint. (NCI)
C26136	Exostosin-Like-1_Protein	Glycosyltransferase	Exostosin-Like 1 Protein|EXTL1|Exostosin-L|Multiple Exostosis-Like Protein	Encoded by human EXTL1 Gene (EXT Family), 676-aa 75-kDa Exostosin-Like 1 is a type II membrane protein glycosyltransferase of the endoplasmic reticulum with strong sequence similarity to EXT1 and EXT2 and likely involved in chain elongation during heparan sulfate and heparin biosynthesis. (NCI)
C26137	Exostosin-Like-2_Protein	Glycosyltransferase	Exostosin-Like 2 Protein|Alpha-1,4-N-acetylhexosaminyltransferase EXTL2|Alpha-GalNAcT EXTL2|EXT-Related Protein 2|EXTL2	Ubiquitously expressed by human EXTL2 Gene (EXT Family), 330-aa 37.5-kDa Exostosin-Like 2 is a type II membrane protein glycosyltransferase of the endoplasmic reticulum that initiates heparan sulfate/heparin biosynthesis by alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate and heparin chains. A soluble EXTL2 form, derived from proteolytic processing of the membrane form, is found in serum. (NCI)
C26138	Exostosin-Like-3_Protein	Glycosyltransferase	Exostosin-Like 3 Protein|EXT-Related Protein 1|EXTL3|Hereditary Multiple Exostoses Gene Isolog|Multiple Exostosis-Like Protein 3|Putative Tumor Suppressor Protein EXTL3	Ubiquitously expressed by human EXTL3 Gene (EXT Family), 919-aa 105-kDa Exostosin-Like 3 is a type II membrane protein glycosyltransferase of the endoplasmic reticulum likely involved in chain initiation and elongation during heparan sulfate/heparin biosynthesis. EXTL3 contains a highly conserved C-terminal region, common to other EXT proteins. (NCI)
C26139	STAT4_Gene	Signal_Transducer_and_Activator_of_Transcription_Family_Gene	STAT4 Gene|STAT4	The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. (LocusLink)
C26140	_2q32_2-q32_3	Chromosome_Band	2q32.2-q32.3	A chromosome band present on 2q
C26141	BCL2-Associated_Athanogene-4	Signaling_Protein	BCL2-associated Athanogene 4|BAG-Family Molecular Chaperone Regulator-4|BAG4	This protein is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost. (LocusLink)
C26142	Cell_Fate_Control	Developmental_Process	Cell Fate Control|Cell Fate Regulation	Cell Fate Control involves intercellular, cellular, and intracellular processes that regulate the generally irreversible commitment of a multipotent cell(s) to a specific ensuing cell development lineage among alternate potential lineage options.
C26143	Deltex_Homolog-1_Protein	Transcription_Repressor_Corepressor	Deltex Homolog 1|DTX1|DTX1 Protein|Deltex Protein 1|Deltex-1|Deltex1|hDTX1|hDx-1	Deltex Homolog 1, encoded by the human DTX1 gene, is a transcription corepressor. Notch1 activates CSL by displacing corerepssors and recruiting coactivator. The N terminus of Deltex Homolog 1 directly interacts with the Notch1 ankyrin repeats, and specifically prevents the recruitment of coactivators and limits CSL activation below the threshold needed for induction of T cell fate. Deltex Homolog 1 may also actively promote B cell fate in common lymphoid progenitors. This protein is expressed in T lymphocytes at all stages of development. (From LocusLink, OMIM and NCI)
C26144	BCL2-Associated_Athanogene-5	Signaling_Protein	BCL2-associated Athanogene 5|BAG-Family Molecular Chaperone Regulator-5|BAG5	Encoded by human BAG5 Gene (BAG1 Family), 447-aa 52-kD BCL2-associated Athanogene 5 contains 4 bag domains and, bound to HSP70/HSC ATPase domains, inhibits HSP70/HSC70 chaperone activity by promoting substrate release. A BAG domain near the C-terminus may bind HSC70/HSP70. (NCI)
C26145	Brain-Specific_Angiogenesis_Inhibitor-1	Angiogenesis_Inhibitory_Protein	Brain-specific Angiogenesis Inhibitor 1|BAI1	BAI1 is a a seven-span transmembrane protein and is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomas. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. (LocusLink)
C26146	Fibroblast_Growth_Factor-9	Fibroblast_Growth_Factor	Fibroblast Growth Factor 9|FGF9|Glia-Activating Factor	Expressed in glia and neurons by human FGF9 Gene (FGF family), 208-aa 23-kDa (precursor) N-glycosylated monomeric secreted Fibroblast Growth Factor 9 has glial growth-stimulating effects and is likely involved in glial cell growth and differentiation, gliosis, and differentiation or survival of neuronal cells. Three molecular species of 30-kDa, 29-kDa and 25-kDa, cleaved at Leu-4, Val-13 and Ser-34 respectively, are found. Expression may be dependent on Sonic hedgehog signaling. (NCI)
C26147	Glycosyltransferase_Gene	Transferase_Gene	Glycosyltransferase Gene	Genes that encode the class of enzymes that catalyze the transfer of glycosyl groups to an acceptor; often another carbohydrate molecule, a protein, or inorganic phosphate. Some enzymes in this class catalyze hydrolysis - the transfer of a glycosyl group to water. Subclasses include Hexosyltransferases, Pentosyltransferases, and Sialyltransferases. (NCI)
C26148	Platelet-Derived_Endothelial_Cell_Growth_Factor-1	Glycosyltransferase	Platelet-Derived Endothelial Cell Growth Factor 1|EC 2.4.2.4|ECGF1|Endothelial Cell Growth Factor 1 (Platelet-Derived)|Gliostatin|PD-ECGF|TP|TdRPase|Thymidine Phosphorylase|Thymidylate Phosphorylase	Endothelial Cell Growth Factor 1 (Platelet-Derived), encoded by the human ECGF1 gene, catalyses the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. This protein may have a role in maintaining the integrity of the blood vessels. It promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. ECGF1 has a highly restricted target cell specificity acting only on endothelial cells. It also limits glial cell proliferation as gliostatin. Defects in ECGF1 are the cause of mitochondrial neurogastrointestinal encephalomyopathy (MNGIE), an autosomal recessive human disease associated with multiple deletions of skeletal muscle mitochondrial DNA (MTDNA). (From LocusLink, Swiss-Prot and NCI)
C26149	B-Cell_Lymphoma-6_Protein	Transcription_Factor	B-Cell Lymphoma 6 Protein|B-cell CLL/Lymphoma-6|BCL5|BCL6|BCL6 Protein|Cys-His2 Zinc Finger Transcription Factor|LAZ-3 Protein|LAZ3|Lymphoma-Associated Zinc Finger Gene on Chromosome 3|ZNF51|Zinc Finger Protein 51	B-Cell Lymphoma 6 Protein is a zinc finger transcription factor containing an N-terminal POZ domain. It acts as a sequence-specific repressor of transcription and its activity is dependent upon DNA-binding and on the N-terminal region containing the POZ motif. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. Target genes have roles in B-cell activation, B-cell differentiation, inflammation, and cell cycle control. Expression of BCL6 in some B-cells early in the antigen response may skew them toward a germinal center fate, away from a plasma cell fate. The BCL6 gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. (from OMIM, LocusLink and NCI)
C26150	Glial_Cell_Proliferation	Cell_Proliferation	Glial Cell Proliferation	Glial Cell Proliferation involves multiplication or reproduction through cell division of various types of glial cells, neural supportive cells in the central and peripheral nervous systems.
C26151	Endothelin-2	Signaling_Protein	Endothelin-2|EDN2|Endothelin 2	Endothelin-2, encoded by the human EDN2 gene, is a macrophage chemoattractant. Endothelins are endothelium-derived vasoconstrictor peptides. The expression of this secreted protein by tumors may modulate the behavior of macrophages such that activated cells accumulate in areas of hypoxia. (From LocusLink, Swiss-Prot and NCI)
C26153	B-Cell_CLL_Lymphoma-10	Apoptosis_Promoter	B-Cell CLL/Lymphoma 10|BCL10|CARD-Containing Proapoptotic Protein|CARD-Like Apoptotic Protein|Caspase-Recruiting Domain-Containing Protein	The gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. (LocusLink)
C26154	Epidermal_Growth_Factor-Like_Protein-6	Glycoprotein	Epidermal Growth Factor-Like Protein 6|DKFZP564P2063|EGF Repeat-Containing Protein 6|EGF-Like 6|EGFL6|EGFL6 Protein|Epidermal Growth Factor Repeat Containing Protein|MAEG|MAM Domain- and EGF Domain-Containing Protein|MAM- and EGF-Containing Protein|W80	Epidermal Growth Factor-Like Protein 6, encoded by the human EGFL6 gene, is a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. This glycoprotein contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an Arg-Gly-Asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. (From LocusLink, Swiss-Prot and NCI)
C26155	ETS_Homologous_Factor	Transcription_Repressor_Corepressor	ETS Homologous Factor|EHF|EHF Protein|ESE3|ESEJ|Epithelium-Specific ETS Factor 3	ETS Homologous Factor, encoded by the human EHF gene, is a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). This protein acts as a transcriptional repressor and may be associated with asthma susceptibility. This protein may be involved in epithelial differentiation and carcinogenesis. Two transcript variants encoding distinct isoforms have been identified for this gene. Dot blot analysis detects high levels of EHF expression in salivary gland, prostate, and trachea, with lower levels detected in colon, mammary gland, pancreas, lung, stomach, appendix, fetal kidney, and fetal lung. (From LocusLink and NCI)
C26156	Ephrin_Receptor-Epha2	Ephrin_Receptor	Ephrin Receptor Epha2|EC 2.7.1.112|EPHA2|Ephrin Type-A Receptor 2|Epithelial Cell Kinase|Epithelial Cell Receptor Protein Tyrosine Kinase|Epithelial Cell Receptor Protein-Tyrosine Kinase|Tyrosine-Protein Kinase Receptor ECK	EphA2 is overexpressed in many cancers, including 40% of breast cancers.  EphA2 can also transform breast epithelial cells in vitro to display properties commonly associated with the development of metastasis. (from Microsc Res Tech 2002 Oct 1;59(1):58-67)
C26157	Elastin_Microfibril_Interfacer-1_Protein	Extracellular_Matrix_Protein	Elastin Microfibril Interfacer 1|EMILIN|EMILIN Protein|EMILIN1|Elastin Microfibril Interface Located Protein|Elastin Microfibril Interface-Located Protein 1	Elastin Microfibril Interface Located Protein, encoded by the human EMILIN gene, is an extracellular matrix glycoprotein found between amorphous elastin and microfibrils. This protein may play a role in elastin deposition. (From LocusLink and NCI)
C26158	_2q36_1	Chromosome_Band	2q36.1	A chromosome band present on 2q
C26159	Ephrin_Receptor-EphA4	Ephrin_Receptor	Ephrin Receptor EphA4|EC 2.7.1.112|EPH-Related Receptor Tyrosine Kinase A4|EPHA4|Ephrin Type-A Receptor 4|Hek8|Receptor Protein-Tyrosine Kinase HEK8|TYRO1 Protein Tyrosine Kinase|Tyrosine-Protein Kinase Receptor SEK	Eph-related receptor tyrosine kinase A4.  Semms to have a function in axon guiding and development of the corticospinal tract. (LocusLink and OMIM)
C26160	Ephrin_Receptor-EphA8	Ephrin_Receptor	Ephrin Receptor EphA8|EC 2.7.1.112|EPH- and ELK-Related Tyrosine Kinase|EPH-and ELK-Related Kinase|EphA8|EphA8 Protein|Ephrin Type-A Receptor 8|Ephrin Type-A Receptor 8 Precursor|HEK3|Hydroxyaryl-Protein Kinase|Protein Tyrosine Kinase EEK|Protein-Tyrosine Kinase|Tyrosine-Protein Kinase Receptor EEK|Tyrosylprotein Kinase	This protein functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. (LocusLink)
C26161	Nervous_System_Development	Organogenesis	Nervous System Development	Human Nervous System Development begins by differentiation of gastrula ectodermal cells into the neural plate, induced by signals from the mesoderm. Further development of this primordium forms the neural crest and neural tube. Neural crest cells become the peripheral nervous system while the neural tube forms the central nervous system. Cells in both structures differentiate into various glial cells and immature neurons that migrate; differentiate axons, dendrites, and synapses; and mature.
C26162	Ephrin_Receptor-EphB1	Ephrin_Receptor	Ephrin Receptor EphB1|EC 2.7.1.112|ELK|EPH Tyrosine Kinase 2|EphB1|EphB1 Protein|Ephrin Type-B Receptor 1|HEK6|NET|Neuronally Expressed Eph-Related Tyrosine Kinase|Tyrosine-Protein Kinase Receptor EPH-2	Eph-related receptor tyrosine kinase B1; may have a role in neurogenesis (Proteome Summary, from LocusLink)
C26163	Frizzled-2_Protein	G_Protein-Coupled_Receptor	Frizzled 2|FZD2|FZD2 Protein|Frizzled Homolog 2 (Drosophila)|Frizzled, Drosophila, Homolog of, 2|Frizzled-2|Fz-2|FzE2|hFz2	Frizzled 2, encoded by the human FZD2 gene, is a 7-transmembrane domain protein that is a receptor with a role in transmembrane signal transmission for Wnt signaling proteins. The expression of the FZD2 gene appears to be developmentally regulated, with high levels of expression in fetal kidney and lung and in adult colon and ovary. (From LocusLink and NCI)
C26164	Frizzled_Domain	Protein_Domain	Frizzled Domain|Frizzled Cystein-Rich Domain|Fz Domain
C26165	Frizzled-3_Protein	G_Protein-Coupled_Receptor	Frizzled 3|FZD3|FZD3 Protein|Frizzled 3 Protein|Frizzled Homolog 3 (Drosophila)|Frizzled, Drosophila, Homolog of, 3|Fz-3|hFz3	Frizzled 3, encoded by the human FZD3 gene, is a G protein-coupled receptor for Wnt proteins and regulates signal transduction in endothelial cells via beta-catenin. It may function in both normal and pathological vasculature differentiation. It also may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Two isoforms are produced by alternative splicing. This protein is widely expressed with relatively high expression in the CNS, including regions of the limbic system, in kidney, pancreas, skeletal muscle, uterus and testis. (From LocusLink, Swiss-Prot and NCI)
C26166	Ephrin_Receptor-EphB2	Ephrin_Receptor	Ephrin Receptor EphB2|DRT|Developmentally-Regulated EPH-Related Tyrosine Kinase|EC 2.7.1.112|ELK-Related Tyrosine Kinase|EPH Tyrosine Kinase 3|ERK|EphB2|EphB2 Protein|Ephrin Type-B Receptor 2|Receptor Protein-Tyrosine Kinase HEK5|Tyrosine-Protein Kinase Receptor EPH-3	Eph-related receptor tyrosine kinase B2; may have a role in neurogenesis (Proteome Summary, from LocusLink)
C26167	Frizzled-4_Protein	G_Protein-Coupled_Receptor	Frizzled 4|FZD4	Frizzled 4, encoded by the human FZD4 gene, is a G protein-coupled receptor that has seven transmembrane domains. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. It may function in cell polarity, cell fate specification and cancer. (From LocusLink, Swiss-Prot and NCI)
C26168	Ephrin_Receptor-EphB3	Ephrin_Receptor	Ephrin Receptor EphB3|EC 2.7.1.112|EPH-Like Tyrosine Kinase 2|EPH-Like Tyrosine Kinase-2|EphB3|EphB3 Protein|Ephrin Type-B Receptor 3|Human Embryo Kinase 2|Tyrosine-Protein Kinase Receptor HEK-2	Eph-related receptor tyrosine kinase B3; may have a role in cell migration in the gut.
C26169	Cell_Migration	Cell_Motility	Cell Migration|Cellular Migration	Cell Migration consists of active directed translocation of a whole cell, or cell body, from one site to another in response to a gradient; distinct from cell motion that involves movement of cell processes (e.g., axons, microvilli, etc.). (NCI)
C26170	Protective_Agent	Pharmacologic_Substance	Protective Agent|Protective Drug	A class of agents used in prophylactic or curative therapy to attenuate the negative side effects of toxins or drugs.  Protective agents belong to various chemical classes, acting through various pharmacological mechanisms.  They may neutralize exogenous poisons, coat mucosa for protection against physical or chemical damage, offer antioxidant protection against free radicals or ionizing radiation, or induce endogenous detoxifying enzymes. (NCI04)
C26171	Epiregulin	Epidermal_Growth_Factor_Superfamily_Protein	Epiregulin|EREG	Epiregulin is a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. Epiregulin functions as a tumor growth-inhibitory factor in HeLa cells. (LocusLink and OMIM)
C26172	Frizzled-7_Protein	G_Protein-Coupled_Receptor	Frizzled 7|FZD7|FZD7 Protein|FZE3|Frizzled Homolog 7 (Drosophila)|Frizzled, Drosophila, Homolog of, 7|Frizzled-7|Fz-7|hFz7	Frizzled 7, encoded by the human FZD7 gene, is a G protein-coupled receptor for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression downregulates APC function and enhances beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas. (From LocusLink and NCI)
C26173	Ets2_Repressor_Factor	Transcription_Repressor_Corepressor	Ets2 Repressor Factor|ERF	Ets2 repressor factor, a transcriptional repressor; suppresses ets-induced transformation; contain an Ets-domain (LocusLink)
C26174	_5q12_2	Chromosome_Band	5q12.2	A chromosome band present on 5q
C26175	ERBB2_Interacting_Protein	Transport_Protein	ERBB2 Interacting Protein|Densin-180-Like Protein|ERBB2IP	ERBB2 interacting protein; acts as an adaptor for the receptor ERBB2/HER2, which may assist in their localization and signalling function; has a PDZ domain and sixteen leucine-rich repeats (LRRs) (LocusLink)
C26176	Ets_Variant_Protein-1	ETS_Family_Protein	Ets Variant Protein 1|ETV1	DNA-binding protein of the ETS family; contains a DNA binding domain (LocusLink)
C26177	Ets_Variant_Protein-4	ETS_Family_Protein	Ets Variant Protein 4|E1A Enhancer-Binding Protein E1AF|ETV4	Member of the ets DNA binding protein family; may bind the adenovirus E1A enhancer. (LocusLink)
C26178	EGF_Receptor_Pathway_Substrate-8	Signaling_Protein	Epidermal Growth Factor Receptor Pathway Substrate 8|EPS8|Epidermal Growth Factor Receptor Kinase Substrate EPS8	Epidermal growth factor receptor pathway substrate 8; has a role in normal and neoplastic cell proliferation; contains an SH3 motif. (LocusLink)
C26179	EGF_Receptor_Pathway_Substrate-15	Signaling_Protein	Epidermal Growth Factor Receptor Pathway Substrate 15|AF-1p Protein|EPS15|Epidermal Growth Factor Receptor Pathway Substrate-15|Protein EPS15	Epidermal growth factor receptor pathway substrate 15; has a role in normal and neoplastic cell proliferation. (LocusLink)
C26180	Frizzled-6_Protein	G_Protein-Coupled_Receptor	Frizzled 6|FZD6|FZD6 Protein	Frizzled 6, encoded by the human FZD6 gene, is a G protein-coupled receptor for Wnt signaling proteins. The FZD6 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and 7 transmembrane domains. However, unlike many other Fz family members, FDZ6 does not contain a C-terminal PDZ domain-binding motif. Frizzled 6 may function in tissue polarity, development and carcinogenesis. (From LocusLink and NCI)
C26183	Gastric_Inhibitory_Polypeptide_Receptor	G_Protein-Coupled_Receptor	Gastric Inhibitory Polypeptide Receptor|GIPR|Glucose-Dependent Insulinotropic Polypeptide	Gastric inhibitory polypeptide (glucose-dependent insulinotropic polypeptide) receptor; signals through stimulatory G-protein to increase intracellular cAMP; member of the G protein-coupled receptor family. (Proteome Summary from LocusLink)
C26184	G_Protein-Coupled_Receptor_Kinase-Interactor-1	Signaling_Protein	G Protein-Coupled Receptor Kinase-Interactor 1|GIT1	G Protein-Coupled Receptor Kinase-Interactor 1: GIT1 is a multidomain protein that is thought to function as an integrator of signaling pathways controlling vesicle trafficking, adhesion and cytoskeletal organization. (from J Cell Sci 2002 Apr 1;115(Pt 7):1497-510)
C26186	G_Protein-Coupled_Receptor_Kinase-Interactor-2	Signaling_Protein	G Protein-Coupled Receptor Kinase-Interactor 2|ARF GTPase-activating protein GIT2|Cool-Associated Tyrosine Phosphorylated Protein 2|GIT2	This protein is a member of the GIT protein family. GIT proteins interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. The gene undergoes extensive alternative splicing. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.
C26187	Frizzled-9_Protein	G_Protein-Coupled_Receptor	Frizzled 9|FZD9|FZD9 Protein	Frizzled 9, encoded by the human FZD9 gene, is a G protein-coupled receptor for Wnt signaling proteins. This gene has been first described as FZD3 in literature. FZD9 is expressed predominantly in brain, testis, eye, skeletal muscle, and kidney. Frizzled 9 may function in tissue polarity, development and carcinogenesis. Heterozygous deletion of the FZD3 gene may contribute to the Williams syndrome phenotype. (From LocusLink and NCI)
C26188	Guanine_Nucleotide_Binding_Protein_Alpha-Z	Heterotrimeric_G_Protein_Subunit	Guanine Nucleotide Binding Protein Alpha Z|GNAZ|Guanine Nucleotide Binding Protein Alpha Z Polypeptide	Guanine nucleotide binding protein is a member of a G protein subfamily that mediates signal transduction; component of pertussis toxin-insensitive (PTX) heterotrimeric G-protein complexes. The protein differs strikingly from other G-alpha subunits in amino acid sequence in a number of regions, and it appeared to be highly enriched in neural tissue. (LocusLink and OMIM)
C26189	Guanine_Nucleotide_Binding_Protein_Alpha-12	Heterotrimeric_G_Protein_Subunit	Guanine Nucleotide Binding Protein Alpha 12|G-Protein Alpha Subunit 12|GNA12	Encoded by human GNA12 Gene (G-Alpha 4 (G(12)) Family), 380-aa 44-kDa membrane-bound Guanine Nucleotide Binding Protein Alpha 12 is a G protein alpha subunit that contains a guanine nucleotide binding site and is involved in transmembrane signaling. (NCI)
C26190	G-Protein_Alpha_Subunit-I2	Heterotrimeric_G_Protein_Subunit	G(i) Alpha 2 Protein|G-Protein Alpha Subunit I2|GNAI2|Guanine Nucleotide Binding Protein Alpha Inhibiting Activity Polypeptide 2	Encoded by single copy human GNAI2 Gene (G-Alpha 1 Family), 354-aa 40-kDa G(i) Alpha 2 Protein is a guanine nucleotide-binding alpha protein subunit of heterotrimeric G protein transducers (alpha, beta, gamma) in transmembrane signaling systems involved in hormonal regulation of adenylate cyclase. Containing virtually identical/similar beta and gamma chains, G proteins are most distinguished by alpha chains. G(i) proteins (alpha(i) subunit) inhibit cyclase in response to beta-adrenergic stimuli. Specific alpha chain regions appear to interact with guanine nucleotides, receptors, effector enzymes, and G protein beta-gamma complex. G proteins that inhibit adenylate kinase are substrates for pertussis toxin. GNAI2 mutations affect cell proliferation. (NCI)
C26191	Heterotrimeric_G_Protein_Subunit_Gene	Signaling_Pathway_Gene	Heterotrimeric G Protein Subunit Gene	Heterotrimeric G Protein Subunit Genes encode Heterotrimeric G Protein signal transducers, attached to the plasma membrane, that connect seven transmembrane cell surface G-protein coupled receptors to intracellular signal transduction effectors and pathways. Inactive G proteins consist of alpha/beta/gamma complexes that signal as dissociated GTP-bound alpha subunit or the beta/gamma complex. GTP hydrolysis by the inherent GTPase reverts the alpha subunit to its inactive (heterotrimeric) form. Receptors coupled to G proteins communicate signals from hormones, neurotransmitters, chemokines, and autocrine and paracrine factors. (NCI)
C26192	GRB2-Associated_Binding_Protein-2	Adaptor_Signaling_Protein	GRB2-Associated Binding Protein 2|GAB2|GAB2 Protein	GRB2-Associated Binding Protein 2 (GAB2), encoded by the human GAB2 gene, is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Upon tyrosine phosphorylation, GAB2 interacts with SHP2 tyrosine phosphatase and GRB2 adapter protein. It is the limiting component of the GAB2-SHP2 complex, signaling Erk MAP kinase activation and terminal differentiation of K562 CML cells. GAB2 also has an inhibitory effect on the activation of ELK1-dependent transcription triggered by a dominant active Ras mutant or under growth factor stimulation. Two alternatively spliced transcripts encode different isoforms and the short isoform is the main isoform. This protein is overexpressed and estrogen regulated in human breast cancer. (From LocusLink, OMIM and NCI)
C26193	Guanine_Nucleotide_Binding_Protein_Beta-1	Heterotrimeric_G_Protein_Subunit	Guanine Nucleotide Binding Protein Beta 1|Beta Subunit, Signal-Transducing Proteins GS/GI|G Protein, Beta-1 Subunit|GNB1|Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 1|Guanine Nucleotide-Binding Protein, Beta-1 Subunit|Transducin Beta Chain 1	Encoded by human GNB1 Gene, Guanine Nucleotide Binding Protein Beta 1 is a heterotrimeric G protein beta subunit that regulates G protein alpha subunits and integrates signals between receptors and effector proteins. (NCI)
C26194	Guanine_Nucleotide_Binding_Protein_Beta-2	Heterotrimeric_G_Protein_Subunit	Guanine Nucleotide Binding Protein Beta 2|G Protein, Beta-2 Subunit|GNB2|Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 2|Signal-Transducing Guanine Nucleotide-Binding Regulatory Protein Beta Subunit|Transducin Beta Chain 2	Expressed in oocytes and blastocysts by human GNB2 Gene, 340-aa 37-kDa Guanine Nucleotide Binding Protein Beta 2 is a heterotrimeric G protein beta subunit with 7 WD repeats and involved in transmembrane signaling as a transducer that regulates G protein alpha subunits and integrates signals between receptors and effector proteins. The G protein beta and gamma subunits are required for GTPase activity, for GTP replacement of GDP, and for G protein/effector interaction. (NCI)
C26195	Guanine_Nucleotide_Binding_Protein_Beta-3	Heterotrimeric_G_Protein_Subunit	Guanine Nucleotide Binding Protein Beta 3|G Protein, Beta-3 Subunit|GNB3|GTP-Binding Regulatory Protein Beta-3 Chain|Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 3|Transducin Beta Chain 3	Encoded by human GNB3 Gene, 340-aa 37-kDa Guanine Nucleotide Binding Protein Beta 3 is a heterotrimeric G protein beta subunit with 7 WD repeats and involved in transmembrane signaling as a transducer that regulates G protein alpha subunits and integrates signals between receptors and effector proteins. The G protein beta and gamma subunits are required for GTPase activity, for GTP replacement of GDP, and for G protein/effector interaction. A splicing polymorphism is associated with essential hypertension and obesity.  (NCI)
C26196	G_Protein-Coupled_Receptor-17	G_Protein-Coupled_Receptor	G Protein-Coupled Receptor 17|GPR17|P2Y-Like Receptor|Probable P2Y Purinoceptor GPR17|R12	Expressed as 2.3-/6.3-kb mRNAs in brain by human GPR17 Gene (GPCR1 Family), alternative isoforms 1 and 2 of 339-/367-aa 41-kDa integral membrane protein G Protein-Coupled Receptor 17 are a putative purine receptor containing 7 transmembrane domains that transduces extracellular signals through heterotrimeric G proteins. (NCI)
C26197	Leucine-Rich_Repeat	Protein_Domain	Leucine-Rich Repeat|LRR|Right-Handed Beta-Alpha Superhelix
C26198	Four_and_a_Half_LIM_Domains-2_Protein	Transcription_Coactivator	Four and a Half LIM Domains 2 Protein|Down-Regulated in Rhabdomyosarcoma LIM Protein|FHL2|Four and a Half LIM Domains 2	Members of the four-and-a-half-LIM domain (FHL) protein family, which are expressed in a tissue- and stage-specific manner, have been reported to function as transcriptional coactivators. Expression of DRAL (FHL2) results in enhancement of NF-kappaB activation.  DRAL (FHL2) is a p53-responsive gene implicated in induction of apoptosis.  DRAL may participate in a regulatory mechanism that coordinates cellular responses controlled by NF-kappaB transcription factor. (from J Biol Chem 2002;277:37045-53 and FEBS Lett 2002;521(1-3):165-9)
C26199	Transcription_Regulatory_Protein	Regulatory_Protein	Transcription Regulatory Protein|Transcriptional Regulatory Protein	Proteins (repressors or activators) which regulate the genetic transcription of the structural genes and/or regulatory genes.
C26200	Leucine_Rich_Repeat_Neuronal-5_Protein	Transmembrane_Protein	Leucine Rich Repeat Neuronal 5 Protein|GAC1|Glioma Amplification on Chromosome 1|Glioma Amplified on Chromosome 1 Protein|Glioma Amplified on Chromosome 1 Protein (Leucine-Rich)|LRRN5	Glioma Amplified on Chromosome 1 Protein, encoded by the human GAC1 gene, belongs to the leucine-rich repeat superfamily. This gene was found to be amplified and overexpressed in malignant gliomas. GAC1 has homology with other proteins that function as cell-adhesion molecules or as signal transduction receptors and is a candidate for the target gene in the 1q32.1 amplicon in malignant gliomas. (From LocusLink and NCI)
C26201	Acidic_Fibroblast_Growth_Factor_Intracellular_Binding_Protein	Ligand_Binding_Protein	Acidic Fibroblast Growth Factor Intracellular Binding Protein|FGF Intracellular Binding Protein|FIBP|Fibroblast Growth Factor (Acidic) Intracellular Binding Protein|Fibroblast Growth Factor Intracellular Binding Protein	Acidic fibroblast growth factor intracellular binding protein; may mediate the mitogenic properties associated with acidic FGF1. (Proteome Summary from LocusLink)
C26202	Fms-Related_Tyrosine_Kinase-3	Growth_Factor_Receptor	Fms-Related Tyrosine Kinase 3|FLT3|Flt-3 Receptor|Stem Cell Tyrosine Kinase 1	Fms-related receptor tyrosine kinase; growth factor receptor for hematopoietic stem and progenitor cells. (LocusLink)
C26203	FMS-Related_Tyrosine_Kinase-4	Vascular_Endothelial_Growth_Factor_Receptor	FMS-Related Tyrosine Kinase 4|FLT4|Tyrosine-Protein Kinase Receptor FLT4|VEGFR3|Vascular Endothelial Growth Factor Receptor 3	A type I membrane protein tyrosine kinase receptor for VEGF-C, vascular endothelial growth factor receptor 3, contains seven immunoglobulin-like C2-type domains.  Vascular endothelial growth factors, working through VEGF receptor-3, promote angiogenesis and metastatic spread of cancer cells.  (from Nat Med 2001. 7:151 & 186)
C26204	G_Protein-Coupled_Receptor-2	G_Protein-Coupled_Receptor	G Protein-Coupled Receptor 2|C-C CKR-10|C-C Chemokine Receptor Type 10|CC Chemokine Receptor 10|CC-CKR-10|CCR-10|Chemokine (C-C) Receptor 10|G-Protein Coupled Receptor 2|GPR2	G Protein-Coupled Receptor 2, encoded by the GPR2 gene, is the receptor for CCL27. The interactions between this receptor and CCL27 are involved in T cell-mediated skin inflammation. (from LocusLink)
C26205	G_Protein-Coupled_Receptor-32	G_Protein-Coupled_Receptor	G Protein-Coupled Receptor 32|GPR32|Probable G Protein-Coupled Receptor GPR32	Encoded by human GPR32 Gene (GPCR1 Family), 356-aa 40-kDa integral membrane protein G Protein-Coupled Receptor 32 is an orphan receptor with greatest similarity to chemoattractant receptors, particularly the formylpeptide receptor (FPR1). (NCI)
C26206	G_Protein-Coupled_Receptor-68	G_Protein-Coupled_Receptor	G Protein-Coupled Receptor 68|GPR68|OGR-1|Ovarian Cancer G Protein-Coupled Receptor 1|Sphingosylphosphorylcholine Receptor	Expressed in spleen, testis, peripheral leukocytes, brain, lung, and placenta by GPR68 Gene (GPCR1 Family), 365-aa 41-kDa 7-transmembrane G Protein-Coupled Receptor 68 is a high affinity receptor for sphingosylphosphorylcholine that acts as a proton-sensing receptor and stimulates PI hydrolysis. The receptor is inactive at pH 7.8 and fully activated at pH 6.8; extracellular histidines are involved in pH sensing. (NCI)
C26207	Forkhead_Box-O1A_Protein	Transcription_Factor	Forkhead Box O1A|FOXO1A	Encoded by human FOXO1A Gene (Forkhead Family), ubiquitous 655-aa 70-kDa Forkhead Box O1A is a probable nuclear transcription factor (phosphorylated by AKT1; insulin-induced) that contains 1 forkhead domain and may play a role in myogenic growth and differentiation. Translocations of the FOXO1A gene - t(2;13)(q35;q14) or t(1;13)(p36;q14) - are associated with alveolar rhabdomyosarcoma-2 that produce FOXO1A/PAX3 and FOXO1A/PAX7 transcriptional activators. (NCI)
C26208	Formyl_Peptide_Receptor-1	G_Protein-Coupled_Receptor	Formyl Peptide Receptor 1|FMLP Receptor|FPR1	Expressed in neutrophils by human FPR1 Gene (GPCR1 Family), 350-aa 38-kDa Formyl Peptide Receptor 1 is a high affinity integral membrane protein GPCR (activates a PI-calcium second messenger system) for N-Formyl-Methionyl peptides, which are powerful chemotactic and activation factors for neutrophils.  (NCI)
C26209	Fractalkine_Receptor	Chemokine_Receptor|G_Protein-Coupled_Receptor	Fractalkine Receptor|Beta Chemokine Receptor-Like 1|C-X3-C CKR-1|CMK-BRL-1|CMKBLR1|CX3C Chemokine Receptor 1|CX3CR1|CX3CR1 Protein|Chemokine (C-C) Receptor-Like 1|Chemokine (C-X3-C Motif) Receptor 1|Chemokine, CX3C Motif, Receptor 1|Fractalkine Receptor CX3CR1|G Protein-Coupled Receptor 13|G Protein-Coupled Receptor V28|G-Protein Coupled Receptor Family 1	Up-regulated by chronic inflammation and encoded by human CX3CR1 Gene (CCR Family, Rhodopsin Family), 355-amino acid 40.4-kD high-affinity Fractalkine Receptor is a seven transmembrane protein expressed in brain, peripheral blood leukocytes, and spleen as a regulator of leukocyte endothelial trafficking: chemotaxis, cell migration, and adhesion. CX3CR1 signals through a pertussis toxin sensitive G-protein to induce migration and contains common GPCR features. Tyrosine sulfation enhances fractalkine-induced cell adhesion. Sharing the CX3C motif, RSV G glycoprotein can use CX3CR1 as a receptor. CX3CR1 may be an HIV envelope protein co-receptor with CD4. Homozygous CX3CR1 I249/M280 haplotype enhances infection and progression to AIDS. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26210	Disabled_Homolog-2_Protein	Regulatory_Protein	Disabled Homolog 2 Protein|DAB2|DAB2 Protein|DOC-2|DOC2|Differentially Expressed Protein 2|Differentially Expressed in Ovarian Cancer 2|Disabled Homolog 2|Disabled Homolog 2, Mitogen-Responsive Phosphoprotein|Mitogen-Responsive Phosphoprotein	Encoded by human tumor suppressor DAB2 Gene, Disabled Homolog 2 Protein is expressed in ovarian, breast, and lung epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, placenta, brainstem, heart, and small intestine. The 770-amino acid 82.5-kD predicted protein has 83% identity with mouse p96 protein, a putative mitogen-responsive phosphoprotein; strongest homology exists in the N-terminal PTB/PID domain. Potentially phosphorylated, DAB2 is a putative component of the CSF-1 cell proliferation signal transduction pathway.  (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26211	Discoidin_Domain_Receptor-2	Receptor_Tyrosine_Kinase	Discoidin Domain Receptor 2|DDR2|DDR2 Protein|Discoidin Domain Receptor Family Member 2|NTRKR3|Neurotrophic Tyrosine Kinase, Receptor-Related 3|Receptor Protein-Tyrosine Kinase TKT|TKT|TYRO10|Tyrosine Kinase Receptor Related to Neurotrophic TRK|Tyrosine-Protein Kinase TYRO 10	Encoded by human DDR2 Gene (InRTK Subfamily) and expressed in heart, lung, brain, placenta, liver, skeletal muscle, pancreas, and kidney, 855-amino acid 96.8-kD precursor Discoidin Domain Receptor 2 is a receptor tyrosine kinase for fibrillar collagen involved in cell adhesion. Mediating fibroblast migration and proliferation, the type I membrane protein contains an intracellular catalytic domain and extracellular coagulation factor 5/8 type C and discoidin domains. RTKs often transduce signals by ligand induced receptor oligomerization, intracellular autophosphorylation, and phosphorylation of cytosolic targets. DDR2 may contribute to cutaneous wound healing. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26212	DEAD-H_Box_Protein-1	Protein_with_Unknown_or_Unclassified_Function	DEAD/H Box Protein 1|ATP-Dependent Helicase DDX1|DBP-RB|DDX1|DDX1 Protein|DEAD-Box Protein 1|DEAD-Box Protein-Retinoblastoma|DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 1|DEAD/H Box-1	Encoded by human DDX1 Gene and highly expressed in neuroectodermal tissues, 740-amino acid 82.4-kD DEAD/H Box Protein 1 has unknown function, contains a SPRY domain, and belongs to the DEAD/H box ATP-dependent RNA helicase family. DEAD box proteins, characterized by the conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26213	DEAD-H_Box_Protein-16	Nuclear_Protein	DEAD/H Box Protein 16|ATP-Dependent RNA Helicase 3|DBP2|DDX16|DDX16 Protein|DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 16|DEAD/H Box 16|DEAH-Box Protein 16|DEAH-Box Protein 2|PRP8 Homolog|Putative Pre-mRNA Splicing Factor RNA Helicase	Encoded by human DDX16 Gene (DEAD/H Subfamily, member 16), ubiquitous 1041-amino acid 119.3-kD nuclear DEAD/H Box Protein 16 is a functional homolog of the Prp8/cdc28 cell cycle progression protein (S. pombe), similar to DEAH box proteins that act as splicing factors. DBP2 is a probable ATP-binding RNA helicase involved in pre-mRNA splicing. DEAD box proteins, characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26215	DEC1_Protein	Protein_with_Unknown_or_Unclassified_Function	DEC1 Protein|DEC1|Deleted in Esophageal Cancer 1	Encoded by human DEC1 Gene, widely expressed 70-amino acid DEC1 Protein is a candidate tumor suppressor protein of unknown function; possibly negative regulation of cell proliferation. (from LocusLink, OMIM, and NCI)
C26216	Beta_Defensin-1_Protein	Immunoprotein	Beta Defensin 1|BD-1|Beta-Defensin 1|DEFB1|Defensin, Beta 1|hBD-1	Encoded by human DEFB1 Gene (Beta-Defensin Family), Beta-Defensin 1 Protein prepropeptide contains a 68-amino acid secreted antimicrobial plasma peptide implicated in cystic fibrosis pathogenesis. Multiple plasma forms are bound to carrier macromolecules. Highest DEFB1 concentrations occur in kidney and female reproductive tract epithelia. DEFB1 may act in innate immunity. Mammalian alpha- and beta-defensins comprise 3.5- to 5-kD cysteine- and arginine-rich neutrophilic microbicidal and cytotoxic peptides. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26217	DEK_Protein	DNA_Binding_Protein	DEK Protein|DEK	Encoded by human DEK Gene, ubiquitous 375-amino acid 43-kD nuclear RNA- and DNA-binding DEK Protein contains a SAP domain and appears to be involved in transcriptional regulation and signal transduction. Most is associated with chromatin, a fraction with RNA. The amount and localization does not change during the cell cycle. DEK binds the HIV-2 'pets' site, interacts with histones, DAXX, and HDAC2, and induces superhelical chromatin alterations with TOP1 or TOP2A. It does not induce histone displacement, but changes nucleosomal DNA topology, and reduces replication efficiency. DEK is a spliced exon-associated spliceosome component mediated by SR protein interactions, such as SRM160. AML-associated t(6;9)(p23;q34) creates fused DEK to CAN with no ORF interruption. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26218	DLEC1_Protein	Protein_with_Unknown_or_Unclassified_Function	DLEC1 Protein|DLEC1|Deleted in Lung and Esophageal Cancer 1	Encoded by human DLEC1 Gene, 1755-amino acid 195.8-kD DLEC1 Protein is a putative negative regulator of cell proliferation. DLC1 appears to suppress the growth of some cancer cell lines. Aberrant expression may be involved in carcinogenesis of the lung, esophagus, and kidney. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26219	DLEU1_Protein	Protein_with_Unknown_or_Unclassified_Function	DLEU1 Protein|DLEU1|Leukemia Associated Protein 1	Expressed in testis, thymus, small intestine, prostate, spleen, peripheral blood lymphocytes, and ovary and encoded by human DLEU1 Gene, DLEU1 Protein is a 72-amino acid putative tumor suppressor protein for BCLL. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26220	DLEU2_Protein	Protein_with_Unknown_or_Unclassified_Function	DLEU2 Protein|DLEU2|Leukemia Associated Protein 2	Expressed in thymus and testis and encoded by human DLEU2 Gene, DLEU2 Protein is an 84-amino acid 10-kD putative tumor suppressor protein. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26221	GRB2-Related_Adaptor_Protein	Adaptor_Signaling_Protein	GRB2-Related Adaptor Protein|GRAP	This protein is a member of the GRB2/Sem5/Drk family. It functions as a cytoplasmic signaling protein which contains an SH2 domain flanked by two SH3 domains. The SH2 domain interacts with ligand-activated receptors for stem cell factor and erythropoietin, and facilitates the formation of a stable complex with the BCR-ABL oncoprotein. This protein also associates with the Ras guanine nucleotide exchange factor SOS1 (son of sevenless homolog 1) through its N-terminal SH3 domain. Expression is restricted to lymphoid tissues.(LocusLink)
C26222	Growth_Factor_Receptor-Bound_Protein-2	Adaptor_Signaling_Protein	Growth Factor Receptor-Bound Protein 2|ASH Protein|Abundant SRC Homology|GRB-2|GRB2|GRB2 Protein	GRB2 forms a complex with activated EGFR and the RAS-specific guanine nucleotide exchange factor SOS1, thereby mediating the growth factor-induced activation of RAS. It also acts to link PDGFRB to the Rac signaling pathway. Due to its ability to cause complex formation between proteins involved in growth signaling pathways, GRB2 has been referred to as an adaptor protein. (from LocusLink and OMIM)
C26224	Growth_Factor_Receptor-Bound_Protein-7	Adaptor_Signaling_Protein	Growth Factor Receptor-Bound Protein 7|GRB7	Grb7 is the prototype of a family of adaptor molecules that also include Grb10 and Grb14 that share a conserved molecular architecture including Src homology 2 (SH2) and pleckstrin homology (PH) domains. It is an adapter-type signaling protein, which is recruited via its SH2 domain to a variety of receptor tyrosine kinases (RTKs), including ErbB2 and ErbB3. Grb7 has been implicated as a downstream mediator of integrin-FAK signal pathways in the regulation of cell migration, although the molecular mechanisms are still not well understood. It is overexpressed in breast, esophageal, and gastric cancers, and may contribute to the invasive potential of cancer cells.(from J Biol Chem 2002;277:29069-77 and J Biol Chem 2002;277:11918-26)
C26226	Xq13	Chromosome_Band	Xq13	A chromosome band present on Xq
C26227	C-X-C_Motif_Chemokine_Receptor-3	Chemokine_Receptor	Chemokine (C-X-C Motif) Receptor 3|CXCR3|G Protein-Coupled Receptor 9|IP10 Receptor|Mig Receptor	CD183 is a G protein-coupled receptor with selectivity for three chemokines, termed IP10 (interferon-g-inducible 10 kDa protein), Mig (monokine induced by interferon-g) and I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to CD183 induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Inhibition by Bordetella pertussis toxin suggests that heterotrimeric G protein of the Gi-subclass couple to CD183. A hallmark of CD183 is its prominent expression in in vitro cultured effector/memory T cells, and in T cells present in many types of inflamed tissues. In addition, IP10, Mig and I-TAC are commonly produced by local cells in inflammatory lesion, suggesting that CD183 and its chemokines participate in the recruitment of inflammatory cells. (from LocusLink)
C26228	Growth_Factor_Receptor-Bound_Protein-10	Adaptor_Signaling_Protein	Growth Factor Receptor-Bound Protein 10|GRB10	Grb10 belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules.  It interacts with IGF1R, PDGFRB, and EGFR and binds to the Raf-1 and MEK1 kinases. Its cellular role is still unclear and a positive as well as an inhibitory role in mitogenesis depending on the cell context has been implicated.  Grb10 may regulate signaling between plasma membrane receptors and the apoptosis-inducing machinery on the mitochondrial outer membrane. (from LocusLink, J Biol Chem 1999;274:35719-24, and Mol Cell Biol 1999;19:6217-28)
C26229	Orphan_G-Protein_Coupled_Receptor	G_Protein-Coupled_Receptor	G Protein-Coupled Receptor, Family C, Group 5, Member C|GPRC5C|Orphan G-Protein Coupled Receptor|Retinoic Acid Responsive Gene Protein	Expressed in stomach, kidney, liver, lung, pancreas, central nervous system, and prostate by human GPRC5C Gene (GPCRc Family), 441-aa 48-kDa 7-transmembrane G Protein-Coupled Receptor Family C Group 5 Member C has an extracellular N-terminal domain, an intracellular C-terminal domain, and conserved cysteines residues. The specific protein function is unknown; it may mediate retinoic acid effects on G protein signal transduction. (NCI)
C26230	Growth_Factor_Receptor-Bound_Protein-14	Adaptor_Signaling_Protein	Growth Factor Receptor-Bound Protein 14|GRB14	Member of the GRB7 family of adapter proteins; identified as a partner of the insulin receptor where it acts as a modulator of insulin signaling. (from J Biol Chem 2002;277:4845-52)
C26231	Adaptor_Signaling_Protein	Signaling_Protein	Adaptor Signaling Protein|Adaptor Protein	A class of signaling pathway proteins that function to mediate the coupling of multiple cell surface receptors to downstream signaling pathways in the regulation of various cellular functions. (from Oncogene 2001;20:6315-21)
C26232	G_Protein-Coupled_Receptor_Kinase-2-Like_Protein	G_Protein-Coupled_Receptor_Kinase_Family	G Protein-Coupled Receptor Kinase 2-Like|EC 2.7.1.-|G Protein-Coupled Receptor Kinase 2 (Drosophila)-Like|G Protein-Coupled Receptor Kinase GRK4|G Protein-Dependent Receptor Kinase 4|GPRK2L|ITI1	Expressed primarily in testis and brain by human GPRK2L Gene (GPRK Family), one of 4 alternative isoforms (GRK4A, B, C, D) of 578-/546-/532-aa 67-kDa G Protein-Coupled Receptor Kinase 2-Like is a Ser/Thr kinase containing an RGS domain that phosphorylates activated GPCRs and may play a role in receptor desensitization. Only full-length GRK4D has kinase activity, can phosphorylate rhodopsin, and is inhibited by calmodulin. The other isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. (NCI)
C26233	G_Protein-Coupled_Receptor_Kinase_Family	Serine-Threonine_Protein_Kinase	G Protein-Coupled Receptor Kinase Family|EC 2.7.1.-	G protein-coupled receptor kinases regulate G protein-coupled receptors through phosphorylation.
C26234	G_Protein-Coupled_Receptor_Kinase_Gene	Serine-Threonine_Protein_Kinase_Gene	G Protein-Coupled Receptor Kinase Gene	G Protein-Coupled Receptor Kinase Genes encode G Protein-Coupled Receptor Kinases, which regulate through phosphorylation the signaling function of G protein-coupled receptors and signal transduction. (NCI)
C26235	G_Protein-Coupled_Receptor_Kinase-5	G_Protein-Coupled_Receptor_Kinase_Family	G Protein-Coupled Receptor Kinase 5|EC 2.7.1.-|G-Protein-Coupled Receptor Kinase 5|GPRK5	Expressed in heart, placenta, lung, skeletal muscle, brain, liver, pancreas, and kidney by human GPRK5 Gene (GPRK Family), 590-aa 68-kDa G Protein-Coupled Receptor Kinase 5 contains an RGS domain and specifically Ser/Thr phosphorylates and regulates activated forms of GPCRs. (NCI)
C26236	Guanine_Nucleotide-Releasing_Factor-2	Guanine_Nucleotide_Exchange_Factor	Rap Guanine Nucleotide Exchange Factor 1|C3G Protein|CRK SH3-binding GNRP|GRF2|Guanine Nucleotide-Releasing Factor 2|Rap Guanine Nucleotide Exchange Factor (GEF) 1	Ubiquitously expressed by human GRF2 Gene (as at least 2 alternative isoforms), Guanine Nucleotide-Releasing Factor-2 is an adaptor-type Ras-GEF/SH2-domain protein involved in signal transmission from cell surface to the nucleus. GRF2 binds to CRK and GRB2/ASH SH3 domains and transduces signals to activate RAS. (from LocusLink)
C26237	G_Protein-Coupled_Receptor_Kinase-6	G_Protein-Coupled_Receptor_Kinase_Family	G Protein-Coupled Receptor Kinase 6|EC 2.7.1.-|G Protein-Coupled Receptor Kinase GRK6|GPRK6	Widely expressed by human GPRK6 Gene (GPRK Family), alternative isoforms A (576-aa) and B (589-aa) of membrane-bound 66-kDa G Protein-Coupled Receptor Kinase 6, containing an RGS domain and DLG and ENIL motifs, specifically Ser/Thr phosphorylate activated forms of GPCRs and may be involved in desensitization of D2/D3 dopamine receptors. (NCI)
C26238	Ionotrophic_Glutamate_Receptor_AMPA3	Cell_Surface_Receptor	Glutamate Receptor, Ionotrophic, AMPA 3|AMPA 3|GRIA3	Subunit 3 of the AMPA subtype of ionotropic glutamate receptor; important for excitatory neurotransmission
C26239	Metabotropic_Glutamate_Receptor-1	G_Protein-Coupled_Receptor	Glutamate Receptor, Metabotropic 1|GRM1	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of the GRM1 gene have been described but their full-length nature has not been determined. (LocusLink)
C26240	_11q14_1	Chromosome_Band	11q14.1	A chromosome band present on 11q
C26241	Metabotropic_Glutamate_Receptor-5	G_Protein-Coupled_Receptor	Glutamate Receptor, Metabotropic 5|GRM5	The metabotropic glutamate receptors are a family of G protein-coupled neurotransmitter receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties; activates phospholipase C and calcium-induced chloride channels (LocusLink)
C26242	G_Protein-Coupled_Receptor_Kinase-7	G_Protein-Coupled_Receptor_Kinase_Family	G Protein-Coupled Receptor Kinase 7|EC 2.7.1.-|G Protein-Coupled Receptor Kinase GRK7|GPRK7	Expressed in retina by human GPRK7 Gene (GPRK family), membrane-bound 553-aa 62-kDa G Protein-Coupled Receptor Kinase 7 is a Ser/Thr kinase containing an RGS domain, a C-terminal CaaX motif for isoprenylation and carboxymethylation, an autophosphorylation site (Ser491), and a geranylgeranylation motif. GRK7 catalyzes rhodopsin phosphorylation, initiating their deactivation in a light-dependent manner. (NCI)
C26243	Metabotropic_Glutamate_Receptor-6	G_Protein-Coupled_Receptor	Glutamate Receptor, Metabotropic 6|GRM6	The metabotropic glutamate receptors are a family of G protein-coupled neurotransmitter receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. (LocusLink)
C26244	Glutathione_S-Transferase_Theta-1	Glutathione_S-Transferase	Glutathione S-Transferase Theta 1|GSTT1|Glutathione-S-Transferase T1	Glutathione S-transferase theta 1 is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. The theta class includes GSTT1 and GSTT2. In humans, the GSTT1 enzyme is found in the erythrocyte and this may act as a detoxification sink. (LocusLink and OMIM)
C26245	Hepatocyte_Growth_Factor-Regulated_Tyrosine_Kinase_Substrate	Signaling_Protein	Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate|HGS	HGS is a downstream signaling molecule.  It undergoes tyrosine phosphorylation in response to IL2, CSF2, or HGF.
C26246	G_Protein_Pathway_Suppressor-1_Protein	Signaling_Protein	G Protein Pathway Suppressor 1 Protein|Arabidopsis FUS6/COP11 Homolog|COP9 Signalosome Complex Subunit 1|G Protein Pathway Suppressor 1|GPS1|GPS1 Protein|MFH Protein	Encoded by human GPS1 Gene, 471-aa 53-kDa G Protein Pathway Suppressor 1 Protein contains a PCI domain and has similarity to signal transduction regulator FUS6 (Arabidopsis). GPS1 suppresses G-protein- and MAP kinase-mediated signal transduction. (NCI)
C26247	Galanin_Receptor-2	G_Protein-Coupled_Receptor	Galanin Receptor 2|GALR2|GALR2 Protein	Galanin Receptor 2 (GALR2) is encoded by the GALR2 gene. Galanin is an important neuromodulator, a 30-amino acid non-C-terminally amidated peptide that potently stimulates growth hormone secretion, inhibits cardiac vagal slowing of heart rate, abolishes sinus arrhythmia, and inhibits postprandial gastrointestinal motility. The actions of galanin are mediated through interaction with specific G protein-coupled receptors. GALR2 interacts with the N-terminal residues of the galanin peptide. Galanin Receptor 2 decreases cAMP through an inhibitory G-protein and stimulates phospholipase C and mobilizes calcium through Gq/G11. The primary signaling mechanism for GALR2 is through the phospholipase C/protein kinase C pathway (via Gq). (From LocusLink and NCI)
C26248	G_Protein_Pathway_Suppressor-2_Protein	Signaling_Protein	G Protein Pathway Suppressor 2 Protein|G Protein Pathway Suppressor 2|G Protein Pathway Suppressor 2 Unknown Protein|GPS2|GPS2 Protein	Encoded by human GPS2 Gene, 2 isoforms of 327-aa 37-kDa G Protein Pathway Suppressor 2 Protein suppress RAS and MAP kinase signal transduction and interfere with c-JNK activation. GPS2 is an integral subunit of NCOR1/HDAC3 complex. GPS2 and TBL1 in NCOR1/HDAC3 interact with NCOR1 repression domain-1 to link to HDAC3 via the NCOR1 SANT domain, which activates HDAC3 activity. NCOR1/HDAC3 inhibits JNK activation through GPS2. GPS also interacts with E2 and E6 proteins. (NCI)
C26249	Regulator_of_G-Protein_Signaling-1_Protein	RGS_Family_Protein	Regulator of G-Protein Signaling 1|B-Cell Activation Protein BL34|Early Response Protein 1R20|RGS1	Induced in response to several activation signals and encoded by B-cell specific immediate early human RGS1 Gene (RGS Family), 196-aa 22.5-kDa Regulator of G-Protein Signaling 1, containing 1 RGS domain, is likely involved in regulation of B-cell activation and proliferation. Potentially regulated by protein kinase(s), RGS1 inhibits signal transduction by increasing GTPase activity of G protein alpha subunits, driving them into the inactive GDP-bound form.  (NCI)
C26250	Regulator_of_G-Protein_Signaling-2_Protein	RGS_Family_Protein	Regulator of G-Protein Signaling 2|RGS2	Encoded by human RGS2 Gene (RGS Family), 211-aa 24-kDa Regulator of G-Protein Signaling 2 is a basic HLH phosphoprotein containing 1 RGS domain with similarity to lymphocyte-specific 1R20 and phosphorylated by PKC. RGS2 inhibits signal transduction by increasing GTPase activity of G protein alpha subunits, driving them into the inactive GDP-bound form. RGS2 also reduces cAMP production by inhibiting odorant-stimulated Alpha-OLF linked adenylyl cyclase type III activity in olfactory neurons. (NCI)
C26251	Regulator_of_G-Protein_Signaling-3_Protein	RGS_Family_Protein	Regulator of G-Protein Signaling 3|RGS3	Encoded by human RGS3 Gene (RGS Family), 519-aa 56.6-kDa cytosolic Regulator of G-Protein Signaling 3 contains 1 RGS domain and is likely phosphorylated by cyclic GMP-dependent protein kinase. RGS3 inhibits G-protein mediated signal transduction by increasing G protein alpha subunit GTPase activity, promoting its conversion to the inactive GDP-bound form. G-protein activation leads to translocation of RGS3 to the plasma membrane. (NCI)
C26252	Regulator_of_G-Protein_Signaling-19_Protein	RGS_Family_Protein	Regulator of G-Protein Signaling 19|G Alpha Interacting Protein|G Protein Signaling Regulator 19|G-Alpha Interacting Protein|GAIP Protein|Guanine Nucleotide Binding Protein Alpha Inhibiting Activity Polypeptide 3 Interacting Protein|RGS19	Expressed most in lung, placenta, liver, and heart by human RGS19 Gene (RGS Family), membrane-bound fatty acylated 217-aa 25-kDa Regulator of G-protein Signaling 19 is a guanosine triphosphatase-activating protein, containing 1 RGS domain, that specifically interacts with G protein GAI3 and down-regulates G Alpha i/G Alpha q-linked signaling. Heavily palmitoylated in the Cys string motif and mainly phosphorylated on Ser residues, RGS19 inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, driving them into the inactive GDP-bound form. RGS19 binds to G-Alpha subfamily 1 members and interacts with GIPC PDZ domain. (NCI)
C26253	Insulin-Like_Growth_Factor-2_Receptor	Insulin-Like_Growth_Factor_Receptor	Insulin-Like Growth Factor 2 Receptor|Cation-Independent Mannose-6 Phosphate Receptor|IGF2R	IGF2R is a 250kDa transmembrane protein. It was originally identified as a receptor for IGFII and M6P-containing proteins (e.g. lysosomal hydrolases). Lysosomal enzymes are sorted to lysosomes via IGF2R either from the Golgi, where the enzymes acquire M6P, or from the extracellular space. The majority of IGF2R molecules are located intracellularly, only 5-10% is present on the cell membrane. IGF2R is also a receptor for TGFbeta latency associated peptide (LAP), proliferin and may bind several molecules independently of M6P, including plasminogen, CD87 or retinoic acid. It is involved in activation of latent TGFbeta.  It is a putative hepatocellular tumor suppressor. (from LocusLink)
C26265	Interleukin-6_Signal_Transducer	Signaling_Protein	Interleukin 6 Signal Transducer|CD130 Antigen|IL6ST|Interleukin Receptor Beta Chain|Membrane Glycoprotein gp130|Oncostatin M Receptor|gp130 Transducer Chain	Widely expressed (not restricted to IL6 responsive cells) by human IL6ST Gene (Type I Cytokine Receptor 2 Family), heterodimeric type I membrane protein (isoform 1) and secreted (isoform 2) Interleukin 6 Signal Transducer contains 5 fibronectin type III domains, an Ig-like C2-type domain, a BOX 1 motif required for JAK interaction/activation, and a WSXWS motif necessary for protein folding, intracellular transport, and cell-surface receptor binding. Part of cytokine receptor complexes, IL6ST is a signal transducer dependent on receptor binding for activation by many cytokines (IL6, CNTF, LIF, IL11, CT1, and OSM) that can utilize gp130 in signal transmission. IL6ST may regulate myocyte apoptosis and have a role in embryonic development. Isoform 2 is an autoantigen in rheumatoid arthritis but it is not specific to RA. (NCI)
C26266	Interleukin-2_Receptor_Gamma	Cytokine_Receptor	Interleukin 2 Receptor Gamma|CD132|Common Cytokine Receptor Gamma Chain|Common Gamma Chain|IL2RG|Interleukin 2 Receptor, Gamma|Interleukin 2 Receptor, Gamma Chain	The interleukin 2 (IL2) receptor gamma chain (IL2RG) is an important signalling component of many interleukin receptors (e.g., IL2,IL4,IL7,IL9, and IL15) and is thus referred to as the common gamma chain. It is necessary for normal growth and differentiation of T cells, B cells, natural killer cells, glioma cells, and cells of the monocyte lineage.  Mutations in this X-chromosome-linked gene cause X-linked severe combined immunodeficiency (XSCID). (from LocusLink and OMIM)
C26267	Interleukin-2_Receptor_Beta	Cytokine_Receptor	Interleukin 2 Receptor Beta|CD122|IL2RB|Intermediate Affinity Interleukin 2 Receptor|Medium Affinity Interleukin 2 Receptor|P70-75	This protein is the beta subunit of the interleukin 2 receptor and is a type I membrane protein. It is involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. It plays a role in the T cell mediated immune response and is a member of the cytokine receptor family. (from LocusLink)
C26268	Interleukin-4_Receptor	Cytokine_Receptor	Interleukin 4 Receptor|CD124|IL4R|IL4RA|Interleukin 4 Receptor Alpha|Interleukin-4 Receptor|Interleukin-4 Receptor Alpha	IL4R when complexed with the common gamma chain (IL2RG) serves as the high-affinity interleukin 4 (IL4) receptor. It plays a major role in immunoglobulin E (IgE) production.
C26269	Interleukin-5_Receptor_Alpha	Cytokine_Receptor	Interleukin 5 Receptor Alpha|CD125|IL5RA|Interleukin 5 Receptor|Interleukin 5 Receptor Alpha Subunit|Interleukin 5 Receptor Type 3|Interleukin 5 Receptor, Alpha	This protein is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. (from LocusLink)
C26270	Interleukin-10_Receptor_Beta	Cytokine_Receptor	Interleukin 10 Receptor Beta|IL10RB	This protein belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction.
C26271	Interleukin-11_Receptor_Alpha	Cytokine_Receptor	Interleukin 11 Receptor Alpha|IL11RA	This protein is the alpha subunit of the high-affinity receptor for interleukin-11. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. (LocusLink)
C26272	Africa	Geographic_Area	Africa	The continent located south of Europe and bordered to the west by the South Atlantic and to the east by the India Ocean.
C26273	Asia	Geographic_Area	Asia	The world's largest continent; it occupies the eastern part of the Eurasian landmass and its adjacent islands and is separated from Europe by the Ural Mountains. (American Heritage Online Dictionary)
C26274	Europe	Geographic_Area	Europe	The continent whose boundaries are the Atlantic Ocean in the west, the Arctic Ocean to the north, the Ural Mountains and Ural River in the east, the Caspian Sea, Caucasus mountains and Black Sea in the southeast and the Mediterranean Sea in the south. (from Wikipedia)
C26275	North_America	Geographic_Area	North America	North America is a continent in the western hemisphere of Earth, bordered to the west by the Pacific Ocean, the east by the Atlantic Ocean, the north by the Arctic Ocean, and connected at the south to South America by the Isthmus of Panama.
C26276	Oceania	Geographic_Area	Oceania	Oceania is a term used to refer to Polynesia (including New Zealand), Melanesia (including New Guinea), Micronesia as a whole, and Australia. (from Wikipedia)
C26277	South_America	Geographic_Area	South America	South America is a continent of the western hemisphere with most of its area in the southern hemisphere.  It is situated between the Pacific Ocean and the Atlantic Ocean and is attached at the north to North America by the Isthmus of Panama.
C26278	Interleukin-7_Receptor	Cytokine_Receptor	Interleukin 7 Receptor|CD127|IL7R|Interleukin 7 Receptor Alpha	This protein is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor common gamma chain (IL2RG). It has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). (from LocusLink)
C26279	Immunoglobulin_Switch_Recombination	Immunoglobulin_Gene_Rearrangement	Immunoglobulin Switch Recombination|Immunoglobulin Isotype-Switch Recombination|Switch Recombination	B-lymphocytes can selectively switch to express different immunoglobulin (Ig) isotypes during the course of an immune response. Selective expression of an Ig isotype is regulated by a sequence-specific rearrangement process that replaces the first active set of Ig heavy-chain (IgH) constant-region exons with one of several other downstream constant-region (CH) genes.
C26280	Immune_Cell_Activation	Immune_Function	Immune Cell Activation	Immune Cell Activation involves cell interaction and cell signaling mechanisms that recognize or respond to the presence of foreign antigen and that induce responsive cells of the immune system to synthesize and secrete defensive products, to proliferate, to differentiate, or to attack the sources of foreign antigens.
C26281	Neutrophil_Activation	Myeloid_Cell_Activation	Neutrophil Activation	Neutrophil Activation involves cell interaction and cell signaling mechanisms of that recognize or respond to the presence of foreign antigen and that stimulate phagocytosis, degranulation, or generation of reactive oxygen products by neutrophils to destroy invading pathogens or to induce acute inflammatory reactions.
C26287	Interleukin-8_Receptor_Alpha	Cytokine_Receptor	Interleukin 8 Receptor Alpha|Chemokine (C-X-C) Receptor 1|High Affinity Interleukin 8 Receptor Type A|IL8 Receptor Type 1|IL8RA|Interleukin 8 Receptor Type 1|Interleukin 8 Receptor Type A|Interleukin 8 Receptor, Alpha	Interleukin-8 is a member of a family of pro-inflammatory cytokines. The best-characterized activities of IL8 include the chemoattraction and activation of neutrophils. There are two IL8 receptors, type 1 (alpha) and type 2 (beta). The type 1 IL8 receptor binds only IL8, while the type 2 IL8 receptor binds also GRO and NAP-2. (from OMIM)
C26288	GAS41_Protein	Protein_with_Unknown_or_Unclassified_Function	YEATS Domain Containing 4|GAS41|GAS41 Protein|Glioma-Amplified Sequence-41|YEATS4	Glioma-Amplified Sequence-41, encoded by the human GAS41 gene, may be a transcription factor and common binding factor for the TACC family proteins. An increased copy number of this gene is found in glioblastoma multiforme and astrocytoma III, and at a high frequency in astrocytoma grades I and II. The GAS41 gene is the first gene found with increased copy number in low-grade glioma, which provides the first evidence that gene amplification can occur in early tumor development. (From OMIM and NCI)
C26289	Interleukin-8_Receptor_Beta	Cytokine_Receptor	Interleukin 8 Receptor Beta|Chemokine (C-X-C) Receptor 2|GRO/MGSA Receptor|High Affinity Interleukin 8 Receptor Type B|IL8 Receptor Type 2|IL8RB|Interleukin 8 Receptor Type 2|Interleukin 8 Receptor Type B	Interleukin-8 is a member of a family of pro-inflammatory cytokines. The best-characterized activities of IL8 include the chemoattraction and activation of neutrophils. There are two IL8 receptors, type 1 (alpha) and type 2 (beta). The type 1 IL8 receptor binds only IL8, while the type 2 IL8 receptor binds also GRO and NAP-2. (from OMIM)
C26290	Integrin-Linked_Kinase	Signaling_Protein	Integrin-Linked Kinase|ILK	Transduction of extracellular matrix signals through integrins influences intracellular and extracellular functions, and appears to require interaction of integrin cytoplasmic domains with cellular proteins. Integrin-linked kinase (ILK), interacts with the cytoplasmic domain of beta-1 integrin. ILK encodes a predicted 451-amino acid protein, with an apparent molecular weight of 59 kD. The ILK protein is a serine/threonine protein kinase with 4 ankyrin-like repeats. ILK regulates integrin-mediated signal transduction. (LocusLink)
C26291	Inhibitor_of_Growth-1_Protein	Regulatory_Protein	Inhibitor of Growth 1|ING1|Inhibitor of Growth Family Member 1	The ING1 protein physically interacts with p53 and appears necessary for the role of p53 in growth inhibition/apoptosis. ING1 shares many biological functions with p53 and has been reported to mediate growth arrest, senescence, apoptosis, anchorage-dependent growth, chemosensitivity, and DNA repair. Some of these functions, such as cell cycle arrest and apoptosis, have been shown to be dependent on the activity of both ING1 and p53 proteins. (from Leuk Res 2002;26:631-5 and Exp Cell Res 2002;279:291-8)
C26292	_2p12-p13	Chromosome_Band	2p12-p13	A chromosome band present on 2p
C26293	Bone_Morphogenetic_Protein-3B	Bone_Morphogenetic_Protein	Bone Morphogenetic Protein 3B|BMP3B|GDF10|Growth Differentiation Factor 10	This protein is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this protein plays a role in skeletal morphogenesis. (LocusLink)
C26294	_7p15-p14_2	Chromosome_Band	7p15-p14.2	A chromosome band present on 7p
C26295	_12q13_3	Chromosome_Band	12q13.3	A chromosome band present on 12q
C26296	_11p15_1	Chromosome_Band	11p15.1	A chromosome band present on 11p
C26297	_9p21-p22	Chromosome_Band	9p21-p22	A chromosome band present on 9p
C26298	_6p22_1	Chromosome_Band	6p22.1	A chromosome band present on 6p
C26299	INHBB_Gene	Protein_Complex_Subunit_Gene	INHBB Gene|INHBB|Inhibin, Beta B (Activin AB Beta Polypeptide) Gene	Human INHBB Gene at 2cen-q13 encodes the Inhibin Beta B subunit, heterodimerized with the Alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin negatively regulates gonadal stromal cell proliferation, has tumor-suppressor activity, and is a marker for primary as well as recurrent granulosa-cell tumors. Inhibin may be both a growth/differentiation factor and a hormone; gonadal and extragonadal expression can vary severalfold in a tissue-specific fashion. Beta B also forms a homodimer, Activin B, and joins with the Beta A subunit to form heterodimeric Activin AB; Activins stimulate FSH secretion. (NCI)
C26300	Hepatocellular_Carcinoma_Protein-HHCM	Protein_with_Unknown_or_Unclassified_Function	Hepatocellular Carcinoma Protein HHCM|HHC(M)|HHCM|HHCM Protein	Encoded by human HHCM Gene, 467-amino acid 52-kD Hepatocellular Carcinoma Protein HHCM exhibits transforming ability on fibroblasts and liver cells. (from LocusLink, Swiss-Prot, and NCI)
C26301	IRAK2_Gene	Serine-Threonine_Protein_Kinase_Gene	IRAK2 Gene|IRAK-2|IRAK2|Interleukin-1 Receptor-Associated Kinase 2 Gene	Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas, and peripheral leukocytes, human IRAK2 Gene (Pelle Ser/Thr Kinase Family) at 3p25.3 encodes 590-aa 65-kDa Interleukin-1 Receptor-Associated Kinase 2, one of two putative Ser/Thr kinases that rapidly associate with the Interleukin-1 Receptor (IL1R) upon stimulation. IRAK2 interacts with TRAF6 and is required for IL1R-induced NF-Kappa-B activation. (NCI)
C26302	IRAK4_Gene	Signaling_Pathway_Gene	IRAK4 Gene|IRAK4|Interleukin-1 Receptor-Associated Kinase 4 Gene|NY-REN-64|REN64	Interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor (TLR, e.g., TLR4; MIM 603030) and IL1R family members, collectively referred to as TIRs. IRAK4 functions in this signal transduction pathway.(supplied by OMIM)
C26303	Hexokinase-2	Kinase	Hexokinase 2|EC 2.7.1.1|HK II|HK2 Protein|Hexokinase II|Hexokinase, Type II|Hexokinase-2, Muscle|Muscle Form Hexokinase	Expressed in human heart, skeletal muscle, and adipose tissue and encoded by insulin-responsive HK2 Gene (Hexokinase Family), outer mitochondrial membrane-bound 917-amino acid 102-kD monomeric Hexokinase 2 promotes glycolysis. HK2 contains glucose- and ATP-binding sites and a hexokinase domain. The C-terminus contains catalytic activity; membrane binding and regulation associate with the N-terminus. Allosterically regulated by product, HK2 converts aldo-/keto-hexoses to hexose-6-phosphate, the first step of many metabolic pathways. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26304	Genes_for_Another_Time	Retired_Concepts	Genes for Another Time
C26305	Chemokine_Receptor-HM74	G_Protein-Coupled_Receptor	G Protein-Coupled Receptor 109B|Chemokine Receptor HM74|GPR109B|HM74|HM74 Protein|Putative Chemokine Receptor, GTP-Binding Protein|Putative G Protein-Coupled Receptor HM74	Expressed in neutrophils, peripheral blood mononuclear cells, and adipose tissue and encoded by human HM74 Gene (GPCR1 Family, Rhodopsin Family), 387-amino acid 44.5-kD integral membrane Chemokine Receptor HM74 is a putative G protein-coupled receptor, containing a 7-transmembrane receptor domain, similar to orphan receptor GPR31, bradykinin receptor B2, and thrombin receptor F2R. HM74 appears to be a nicotinic acid receptor; binding of nicotinic acid to the mouse ortholog PUMA-G or to HM74 results in G protein-mediated decrease in cAMP levels. PUMA-G mediates anti-lipolytic, lipid-lowering effects of nicotinic acid. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26306	IRF3_Gene	Transcription_Coactivator_Gene	IRF3 Gene|IRF3|Interferon Regulatory Factor 3 Gene	IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. (from LocusLink)
C26308	Heterogeneous_Nuclear_Ribonucleoprotein-A3	Nuclear_Protein	Heterogeneous Nuclear Ribonucleoprotein A3|HNRPA3|HNRPA3 Protein|Heterogeneous Nuclear Ribonucleoprotein-Like	Encoded by human HNRPA3 Gene, 379-amino acid 40-kD Heterogeneous Nuclear Ribonucleoprotein A3 is similar to helix destabilizing heterogeneous nuclear ribonucleoprotein A1 (rat) and to heterogeneous ribonucleoproteins (putative components of ribonucleosomes). Containing two RNA recognition motifs (RRM), HNRPA3 belongs to the HNRNP A/B group of basic, GLY-rich proteins. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26309	Homeobox_Protein-A10	Homeobox_Protein	Homeobox Protein A10|Centaurin Alpha 1-Like|HOX1.8|HOX1H|HOXA10|HOXA10 Protein|Homeobox Protein 1H|Homeobox Protein HOXA10	Encoded by human HOXA10 Gene (ABD-B Family) and expressed spatially/temporally in posterior domains during genitourinary development, 496- and 494-amino acid 41-kD Homeobox Protein A10 isoforms are inhibitory transcription factors, containing a common DNA-binding homeobox domain, that may regulate morphogenesis and differentiation by providing anterior-posterior positional identity. HOXA10 protein is also expressed in adult endometrium during early pregnancy. Bound to 5-prime AA[AT]TTTTATTAC 3-prime DNA, HOXA10 may mediate progesterone regulation of uterine EP3 and EP4. HOXA10 also appears to regulate hematopoietic lineage commitment. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26310	Homeobox_Protein-A9	Homeobox_Protein	Homeobox Protein A9|ABD-B|HOX1.7|HOX1G|HOXA9|HOXA9 Protein|Homeobox Protein 1G|Homeobox Protein HOXA9|Homeodomain Protein HOXA9	Encoded by human HOXA9 Gene (ABD-B Family), 272-amino acid 30-kD Homeobox Protein A9 isoforms are class I sequence-specific DNA-binding homeobox transcription factors potentially involved in morphogenesis and myeloid differentiation; expression is spatially and temporally regulated during embryonic development. Frameshifted isoform B contains a distinct C-terminus lacking the homeodomain. HOXA9 acts within a developmental regulatory system that provides specific anterior-posterior positional identity to cells. Associated with acute myeloid leukemogenesis, a chimerically fused in-frame nucleoporin NUP98 amino terminal half to HOXA9 may inhibit differentiation or disrupt nucleocytoplasmic transport. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26311	Homeobox_Protein-C6	Homeobox_Protein	Homeobox Protein C6|CP25|HHO.C8|HOX3C|HOXC6|Homeobox Protein 3C|Homeobox Protein C8|Homeobox Protein HOXC6	Encoded by HOXC6 Gene (ANTP Family), 153- and 235-amino acid (27-kD) Homeobox C6 Protein isoforms are highly conserved sequence-specific DNA-binding homeobox transcription repressors that can cooperate with other HOX proteins and may contribute to the breast cell phenotype through co-operative interactions. As part of a developmental regulatory system that provides anterior-posterior positional identity to cells, HOXC6 may regulate the coordinated expression of multiple genes involved in morphogenesis and differentiation. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26312	HPCA_Protein	Retired_Concepts	HPCA Protein
C26313	Heparanase	Hydrolase	Heparanase|HPSE|HPSE Protein|Heparanase-1	With six potential N-glycosylation sites and hydrophobic stretches suggesting a transmembrane protein, ubiquitous 543-amino acid Heparanase, encoded by human HPSE Gene, is an endoglycosidase (beta-glucuronidase) that degrades heparan sulfate and related proteoglycans in the ECM and vascular basal laminar. Heparan sulfate degradation is key in tumor cell and migrating leukocyte extravasation. Heparanase activity is also important in angiogenesis, wound healing, and smooth muscle proliferation. (from LocusLink, OMIM, and NCI)
C26314	Hydroxysteroid-17-Beta_Dehydrogenase-7	Oxidoreductase	17-Beta-Hydroxysteroid Dehydrogenase 7|17 Beta-Hydroxysteroid Dehydrogenase Type 7|17 Beta-Hydroxysteroid Dehydrogenase Type VII|17-Beta-HSD 7|EC 1.1.1.51|Estradiol 17 Beta-Dehydrogenase 7|HSD17B7|Hydroxysteroid (17-Beta) Dehydrogenase 7	Encoded by human HSD17B7 Gene (SDR Family) and expressed in breast, ovaries, pregnant uterus, placenta, testis, thymus, prostate, fetal liver, and some neural tissues, 341-amino acid 38-kD 17-Beta-Hydroxysteroid Dehydrogenase 7 oxidizes or reduces estrogens and androgens. Responsible for biosynthesis of estradiol in the corpus luteum during pregnancy, the membrane-associated phosphorylated enzyme is nearly 75% identical to rodent proteins and contains a short chain dehydrogenase domain. Close to the transmembrane domain, HSD17B7 contains a 28-residue superficial loop: a candidate prolactin receptor (PRLR)-binding domain. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26315	TAT-Interacting_Protein-TIP30	Transcription_Coactivator	TAT-Interacting Protein TIP30|HIV-1 TAT Interactive Protein 2, 30-kD|HIV-1 TAT-Interacting Protein 30-kD|HTATIP2|HTATIP2 Protein|TAT-Interacting Protein (30kD)	Encoded by human HTATIP2 Gene (SDR Family), the ubiquitous 242-amino acid 30-kD TAT-Interacting Protein TIP30 is a nuclear and membrane-associated tumor suppressor that contains several conserved features: a semialdehyde dehydrogenase domain, a N-terminal beta-alpha-beta fold that may bind NADP(H), and a 20-amino acid N-terminal alpha helix that may enable protein docking. Proapoptotic TIP30 activity resides in the N-terminal domain. A 133-amino acid membrane-associated variant TC3 Protein contains a unique short C-terminus that confers antiapoptotic properties. TIP30 appears to be a RNA polymerase II transcription co-activator and may function as a co-activator for HIV-1 TAT protein. TIP30 may suppress metastasis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26316	Interferon-Induced_Transmembrane_Protein-1	Signaling_Protein	Interferon-Induced Transmembrane Protein 1|9-27|CD225 Antigen|Fragilis Homolog|IFI17|IFITM1|IFITM1 Protein|Interferon-Induced Protein 17|Interferon-Inducible Protein 9-27|Interferon-Inducible Transmembrane Protein 11|LEU-13 Antigen|LEU13	Encoded by human IFITM1 Gene (IFN-Induced Transmembrane Protein Family), 125-amino acid 14-kD Interferon-Induced Transmembrane Protein 1 is an IFN-alpha- and -gamma-inducible membrane protein subunit of a multimeric complex involved in antiproliferative and homotypic adhesion signal transduction. IFITM1 Protein appears to demarcate germ cells from somatic neighbors and to mark the onset of germ cell competence. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26317	Interferon_Alpha-13	Interferon_Alpha	Interferon Alpha 13|IFNA13|IFNA13 Protein|Interferon Alpha-D|LeIF D	Encoded by human IFNA13 Gene (IFN Alpha Family) and expressed by macrophages, secreted 189-amino acid 21.7 kD (precursor) Interferon Alpha 13 contains the interferon alpha/beta domain and appears to regulate antiviral defense, cell growth, and immune activation; it stimulates the production of a protein kinase and an oligoadenylate synthetase. Interferons Alpha-13 and Alpha-1 have identical protein sequence. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26318	Interferon_Alpha-2	Interferon_Alpha	Interferon Alpha 2|IFNA2|IFNA2 Protein|Interferon Alpha-A|LeIF A	Encoded by human INFA2 Gene (IFN Alpha Family) and expressed by macrophages, secreted 188-amino acid 21.6 kD (precursor) Interferon Alpha 2 contains the interferon alpha/beta domain, exhibits interferon-alpha/beta receptor ligand activity, and appears to regulate antiviral defense, cell growth, and immune activation. It stimulates the production of a protein kinase and an oligoadenylate synthetase. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26319	Interferon_Omega-1	Interferon	Interferon Omega 1|IFN-Alpha-Like|IFN-Omega 1|IFNW1|IFNW1 Protein|Interferon Alpha-II-1	Encoded by human IFNW1 Gene (IFN Alpha, Beta, Delta Family), secreted 195-amino acid 22 kD (precursor) Interferon Omega 1, a type I interferon protein containing the interferon alpha/beta domain, appears to regulate antiviral defense, cell growth, and immune activation. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26320	Caribbean	Geographic_Area	Caribbean|West Indies	The Caribbean or the West Indies is a group of islands in the Caribbean Sea. These islands curve southward from the bottom tip of Florida to the Northwest of Venezuela in South America. They are at least 7 000 islands, islets, reefs and cayes in the region. There exist twenty-five territories, including sovereign states, overseas departments and dependencies. (from Wikipedia)
C26321	Leukemia_Inhibitory_Factor_Receptor	Cytokine_Receptor	Leukemia Inhibitory Factor Receptor|LIF-R|LIFR	Leukemia Inhibitory Factor (LIF), encoded by the LIF gene, is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action is mediated through a high-affinity receptor complex composed of Leukemia Inhibitory Factor Receptor (a low-affinity LIF binding chain) and gp130 (a high-affinity converter subunit). The high-affinity complex also binds oncostatin M, a related cytokine. Both Leukemia Inhibitory Factor Receptor and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin. (from OMIM)
C26322	Growth_Differentiation_Factor-5	Bone_Morphogenetic_Protein	Growth Differentiation Factor 5|GDF5|GDF5 Protein	Growth Differentiation Factor 5, encoded by the human GDF5 gene, is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein is predominantly expressed in long bones during human embryonic development. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. (From LocusLink, Swiss-Prot and NCI)
C26323	Hematologic_Disorder	Hematopoietic_System_Disorder	Hematologic and Lymphocytic Disorder
C26324	Non-Neoplastic_Hematologic_Disorder	Hematologic_Disorder	Non-Neoplastic Hematologic and Lymphocytic Disorder|Non-Malignant Hematologic and Lymphocytic Disorder|nonmalignant hematologic disorders	Disorders of the blood, some of which lead to leukemia.
C26326	Non-Neoplastic_Connective_and_Soft_Tissue_Disorder	Connective_and_Soft_Tissue_Disorder	Non-Neoplastic Connective and Soft Tissue Disorder|Non-Neoplastic Connective and Soft Tissue Disease|Non-Neoplastic Connective and Soft Tissue Diseases|Non-Neoplastic Connective and Soft Tissue Disorders
C26327	Protein-Lysine-6-Oxidase	Oxidoreductase	Protein-Lysine 6-Oxidase|EC 1.4.3.13|LOX|Lysyl Oxidase	Lysyl oxidase; a copper-dependent enzyme that initiates the crosslinking of collagens and elastin, oxidizes lysine residues to alpha-aminoadipic-delta-semialdehyde. (LocusLink)
C26328	Growth_Differentiation_Factor-8	Bone_Morphogenetic_Protein	Growth Differentiation Factor 8|GDF8|GDF8 Protein	Growth Differentiation Factor 8, encoded by the human GDF8 gene, is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This protein plays a role in the control and maintenance of skeletal muscle mass. It acts specifically as a negative regulator of skeletal muscle growth by signaling through receptor serine/threonine kinases. This protein is synthesized as a preprotein activated by 2 proteolytic cleavages. Removal of the signal sequence is followed by cleavage at a tetrabasic processing site, resulting in a 26-kD amino-terminal propeptide and a 12.5-kD carboxy-terminal peptide, a dimer of which is the biologically active portion of the protein. (From LocusLink, OMIM and NCI)
C26329	Leukotriene-B4_Receptor	G_Protein-Coupled_Receptor	Leukotriene B4 Receptor|Chemoattractant Receptor-Like 1|Chemokine Receptor-Like 1|G Protein-Coupled Receptor 16|LTB4R|P2Y Purinoceptor 7	Leukotriene B4 Receptor, encoded by the LTB4R gene, belongs to family 1 of G-protein coupled receptors. This protein is a receptor for extracellular ATP, UTP and ADP, and its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. This protein may be the cardiac P2Y receptor involved in the regulation of cardiac muscle contraction through modulation of L-type calcium currents. It is also a receptor for leukotriene B4, a potent chemoattractant involved in inflammation and immune response. It is expressed at highest levels in heart, skeletal muscle and at lower levels in brain and liver, with high level of expression in lymphoid tissues. (from Swiss-Prot)
C26330	Ghana	Country	Ghana|288|GH|GHA	A country in Western Africa, bordering the Gulf of Guinea, between Cote d'Ivoire and Togo. (CIA World Factbook 2002)
C26331	Latent_TGF_Beta_Binding_Protein-2	Ligand_Binding_Protein	Latent TGF Beta Binding Protein 2|LTBP2|Latent Transforming Growth Factor Beta Binding Protein 2	Latent TGF Beta Binding Protein 2, encoded by the LTBP2 gene, is a latent transforming growth factor-beta (TGF-beta) binding protein. Binding of this protein to TGF-beta in the extracellular-matrix serves as an important mechanism to regulate TGF-beta function. Mutations in LTBP2 have been identified in two instances of atypical Marfan syndrome. (LocusLink)
C26332	Leukocyte_Tyrosine_Kinase	Receptor_Tyrosine_Kinase	Leukocyte Tyrosine Kinase|EC 2.7.1.112|LTK|Leukocyte Tyrosine Kinase Receptor|Protein Tyrosine Kinase-1	Leukocyte Tyrosine Kinase is encoded by the human LTK gene. A set of cDNAs represents differently spliced human LTK mRNAs. These cDNAs predict a truncated receptor protein lacking the tyrosine kinase domain and a soluble receptor protein that has neither a transmembrane nor a tyrosine kinase domain. The LTK gene produces not only the putative receptor tyrosine kinase for unknown ligand but also multiple protein products that may have different functions. (from OMIM)
C26333	Lymphocyte_Antigen-LY6E	Growth_Factor_Receptor	Lymphocyte Antigen 6 Complex, Locus E|LY6E|Retinoic Acid-Induced Gene E Protein|Stem Cell Antigen 2|Thymic Shared Antigen-1	LY6E gene encodes a cell surface protein containing 20 N-terminal amino acids corresponding to a signal peptide and an extracellular sequence of 111 amino acids. LY6E protein shares some homology with CD59 and some growth factor receptors; highest homology is with the murine LY6 multigene family of small cysteine-rich proteins differentially expressed in several hematopoietic cell lines and with apparent signal transduction function. RIGE is the closest human LY6 family homolog. RIGE expression is not restricted to myeloid differentiation; it is also present in thymocytes and other tissues at different levels. By Northern blot analysis, the highest expression of RIGE was found in liver, kidney, and ovary in addition to peripheral blood leukocytes. (OMIM)
C26334	IGF-II_mRNA-Binding_Protein-3	RNA_Binding_Protein	IGF-II mRNA-Binding Protein 3|IMP-3|KOC1|KOC1 Protein	Encoded by human KOC1 Gene, IGF-II mRNA-Binding Protein 3 contains a KH domain and binds to the 5-prime UTR of the IGF-II leader 3-prime mRNA. It may repress translation of IGF-II during late development. (from LocusLink and NCI)
C26335	Kinase_Suppressor_of_RAS-1	Serine-Threonine_Protein_Kinase|Signaling_Protein	Kinase Suppressor of RAS-1|KSR|KSR Protein|Kinase Suppressor of Ras	Similar to RAS kinase suppressor (Drosophila) and encoded by human KSR Gene (SER/THR PK Family), Kinase Suppressor of RAS-1 is a positive modulator of RAS-MAP kinase signaling. KSR Homologs are found in C. elegans and mouse. The predicted 873-amino acid mouse protein contains a kinase domain similar to RAF kinases; human protein is nearly 95% similar to mouse. In unstimulated cells, CTAK1 constitutively associates with KSR1, phosphorylating Ser392 and conferring cytoplasmic sequestration by 14-3-3 binding. In response to growth factor, KSR1 Ser392 phosphorylation falls, allowing KSR1 to localize with activated RAS and RAF1 at the plasma membrane and facilitating phosphorylation required for activation of MEK and MAPK. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26336	Middle_East	Geographic_Area	Middle East	Countries of southwest Asia and northeastern Africa.  The CIA Factbook considers this region to include those countries east of Egypt and south of Turkey and extending to Iran in the east.
C26337	PTPN11_Gene	Non-Receptor_Protein_Tyrosine_Phosphatase_Gene	PTPN11 Gene|BPTP3|CFC|NS1|PTP-1D|PTP2C|PTPN11|Protein Tyrosine Phosphatase, Non-Receptor Type 11 (Noonan Syndrome 1) Gene|SH-PTP2|SH-PTP3|SHP-2|SHP2	Widely expressed (abundant in heart, brain, and skeletal muscle), human PTPN11 Gene (Non-Receptor PTP Family) encodes 593-aa 68-kDa cytoplasmic Non-Receptor Type 11 Protein Tyrosine Phosphatase, containing a catalytic domain and 2 tandem phosphotyrosine binding SH2 domains that mediate substrate interactions (MPZL1, PTPNS1) and may modulate phosphatase activity. PTPN11 appears to regulate signaling events involved in mitogenesis, metabolic control, transcription, migration, adhesion, cell morphogenesis, and blood cell development. Activated by IL-6, PTPN11 regulates RAFT Kinase and may regulate apoptosis. PDGF-induced C-terminal tyrosine phosphorylation creates a binding site for the GRB2 SH2 domain. PTPN11 also appears to be involved in EGFR signaling and to potentiate the MAP kinase pathway. PTPN11 defects cause LEOPARD syndrome, Noonan syndrome, and JMML. (NCI)
C26338	Lymphoid_Nuclear_Protein-4	Transcription_Factor	Lymphoid Nuclear Protein 4|LAF-4 Protein|LAF4|LAF4 Protein|Lymphoid Nuclear Protein Related to AF4|MLLT2-Related Protein	Preferentially expressed in lymphoid tissues (highest in thymus) and encoded by human LAF4 Gene (LAF4/MLLT2 Family), 1227-amino acid 134-kD nuclear DNA-binding transcriptional activator Lymphoid Nuclear Protein 4 may function in lymphoid development and oncogenesis. Greatest similarity to MLLT2 occurs in the N-terminal and C-terminal regions. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26339	Non-Receptor_Type_1_Protein_Tyrosine_Phosphatase	Protein_Tyrosine_Phosphatase	Protein Tyrosine Phosphatase, Non-Receptor Type 1|PTPN1	Encoded by human PTPN1 Gene (Non-Receptor PTP Family), 435-aa 50-kDa Non-Receptor Type 1 Protein Tyrosine Phosphatase is a negative regulator of insulin signaling by dephosphorylating insulin receptor kinase and is associated with the endoplasmic reticulum via its C-terminal domain and its phosphatase domain oriented towards the cytoplasm. PTPN1 may also dephosphorylate EGFR kinase, as well as JAK2 and TYK2 kinases, suggesting a role in cell growth control, and cell response to interferon stimulation. Protein Tyrosine Phosphatases typically regulate cellular processes such as cell growth, differentiation, and mitotic cycle. Oxidation of Cys-215 forms a 4-amino-3-isothiazolidinone serine cross-link, triggering a conformational change that inhibits substrate binding and activity; the active site is restored by reduction. (NCI)
C26340	Lysosomal-Associated_Membrane_Protein-3	Transmembrane_Protein	Lysosomal-Associated Membrane Protein 3|LAMP3|LAMP3 Protein|Lysosome-Associated Membrane Glycoprotein, Dendritic Cell-Specific|TSC403 Protein	Expressed in appendix, thymus, lymph node, lung, and spleen and encoded by human LAMP3 Gene (LAMP Family), Lysosomal-Associated Membrane Protein 3 is likely involved in antigen processing by lymphoid dendritic cells that capture antigens, differentiate, and induce T-cell responses. Expression increases in mature interdigitating dendritic cells in T-cell areas. A 416-amino acid 70- to 90-kD type I integral membrane protein (larger than predicted, 44-kD), DCLAMP contains N-and O-glycosylation sites, a LAMP domain, a large extracellular domain, a transmembrane domain, and a 10-amino acid cytoplasmic domain containing a conserved GY lysosomal targeting motif. Expression is up regulated in carcinomas of esophagus, colon, rectum, ureter, stomach, breast, fallopian tube, thyroid, and parotid tissues. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26341	Non-Receptor_Type_12_Protein_Tyrosine_Phosphatase	Protein_Tyrosine_Phosphatase	Protein Tyrosine Phosphatase, Non-Receptor Type 12|PTPN12|Protein Tyrosine Phosphatase G1	Encoded by human PTPN12 Gene (Non-Receptor PTP Family), 780-aa 88-kDa cytoplasmic Non-Receptor Type 12 Protein Tyrosine Phosphatase contains a C-terminal PEST motif protein-protein interaction domain. PTPN12 binds to and dephosphorylate the c-ABL product. It also interacts with, and dephosphorylates, cytoskeletal and cell adhesion molecules, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and Paxillin, suggesting a role in controlling cell shape and mobility. PTPs typically regulate cell growth, differentiation, and mitotic cycle. Defects in PTPN12 are found in some colon cancers. (NCI)
C26342	Non-Receptor_Type_22_Protein_Tyrosine_Phosphatase	Protein_Tyrosine_Phosphatase	Protein Tyrosine Phosphatase, Non-Receptor Type 22|PTPN22	Predominantly expressed in lymphoid tissues as distinct alternative isoforms by human PTPN22 Gene (Non-Receptor PTP Family), Non-Receptor Type 22 Protein Tyrosine Phosphatase associates with and appears to regulate adapter protein CBL function and its associated protein kinases in the T-cell receptor signaling pathway. (NCI)
C26343	Non-Receptor_Type_6_Protein_Tyrosine_Phosphatase	Protein_Tyrosine_Phosphatase	Protein Tyrosine Phosphatase, Non-Receptor Type 6|Hematopoietic Cell Protein Tyrosine Phosphatase|PTPN6|Protein Tyrosine Phosphatase 1C|Protein Tyrosine Phosphatase SHP-1	Expressed predominantly in hematopoietic cells by human PTPN6 Gene (Non-Receptor PTP Family), 3 distinct alternative isoforms of cytoplasmic serine/tyrosine phosphorylated Non-Receptor Type 6 Protein Tyrosine Phosphatase contain two tandem N-terminal phosphotyrosine binding SH2 domains that mediate interaction with substrates and may modulate phosphatase activity through interaction with other cellular components. A key regulator of hematopoiesis, PTPN6 interacts with, and dephosphorylates, many phosphoproteins involved in hematopoietic cell signaling pathways. PTPN6 binds to PTPNS1, LILRB1, and LILRB2. Protein Tyrosine Phosphatases typically regulate cell growth, differentiation, and mitotic cycle. (NCI)
C26344	Large_Tumor_Suppressor_Homolog-1_Protein	Serine-Threonine_Protein_Kinase	Large Tumor Suppressor Homolog 1|LATS (Large Tumor Suppressor) Homolog 1|LATS Homolog 1|LATS1|LATS1 Protein|Large Tumor Suppressor 1	Widely expressed in fetal and adult tissues and encoded by human LATS1 Gene (SER/THR PK Family), conserved putative tumor suppressor Large Tumor Suppressor Homolog 1 is an 1130-amino acid 127-kD Ser/Thr protein kinase cell cycle regulator containing a catalytic domain and an UBA/TS-N domain. The C-terminal kinase domain of human and mouse proteins share 99% identity; human and Drosophila share 74% identity. The kinase domain and N-terminal region interact, suggesting intramolecular regulation. Phosphorylated in a cell cycle-dependent manner (late prophase-metaphase), LATS1 is a negative regulator of CDC2/cyclin A. In early mitosis, it complexes (via the N-terminal region) with the mitotic apparatus cell cycle controller CDC2 kinase; the complex shows reduced H1 histone kinase activity. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26345	Non-Receptor_Type_7_Protein_Tyrosine_Phosphatase	Protein_Tyrosine_Phosphatase	Protein Tyrosine Phosphatase, Non-Receptor Type 7|Hematopoietic Protein Tyrosine Phosphatase|PTPN7|Protein Tyrosine Phosphatase LC-PTP	Preferentially expressed as 2 distinct alternative isoforms in thymic and spleen hematopoietic cells by human early response PTPN7 Gene (Non-Receptor PTP Family) in lymphokine-stimulated cells, cytoplasmic Non-Receptor Type 7 Protein Tyrosine Phosphatase is likely involved in regulation of TCR signaling through dephosphorylating MAP kinase pathway molecules; the noncatalytic N-terminus interacts with and suppresses MAP kinase activities. PTPN7 appears to regulate T and B lymphocyte development and signal transduction. Protein Tyrosine Phosphatases typically regulate cellular processes including cell growth, differentiation, and mitotic cycle. (NCI)
C26346	Large_Tumor_Suppressor_Homolog-2_Protein	Serine-Threonine_Protein_Kinase	Large Tumor Suppressor Homolog 2|LATS (Large Tumor Suppressor) Homolog 2|LATS2|LATS2 Protein|Large Tumor Suppressor 2|Tumor Suppressor LATS/WARTS Homolog 2	Expressed in many tissues (highest in heart and skeletal muscle) and encoded by human LATS2 Gene (SER/THR PK Family), the 125-kD nuclear Ser/Thr protein kinase Large Tumor Suppressor Homolog 2 contains seven PAPA repeats (dipeptide proline-alanines likely involved in protein-protein interactions) and a C-terminal kinase domain. Human and mouse proteins are most closely related to LATS1 proteins, followed by Drosophila Lats. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26347	Lymphocyte_Cytosolic_Protein-2	Adaptor_Signaling_Protein|Immunoprotein	Lymphocyte Cytosolic Protein 2|76 kD Tyrosine Phosphoprotein|LCP2|LCP2 Protein|SH2 Domain-Containing Leukocyte Protein, 76kD|SH2 domain-containing leukocyte protein of 76kD|SLP-76|SLP-76 Tyrosine Phosphoprotein|SLP76	Encoded by human LCP2 Gene and expressed in peripheral leukocytes, spleen, thymus, T-cells, B-cells, and monocytes, modular 533-amino acid 76-kD adaptor/scaffold Lymphocyte Cytosolic Protein 2 contains three domains; a PEST domain and phosphorylatable tyrosine residues in the acidic N-terminus, a GRB2 binding site in the central proline-rich domain, and a C-terminal SH2 domain. SLP-76 associates constitutively or inducibly with GRB2 and FYB adapter proteins and with ZAP70 and SYK as a substrate. By supporting receptor-mediated signal transduction, SLP-76 promotes thymic development and T-cell development and activation, as well as mast cell and platelet function. SLP-76 may collect all pre-TCR signals that drive thymocyte development and appears required for separate development of lymphatic vessels from blood vessels. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26348	Left-Right_Determination_Factor-B	Transforming_Growth_Factor-Beta	Left-Right Determination Factor B|LEFTB|Left-Right Determination Factor B Preproprotein|Lefty 2 Homolog|Lefty-B Protein	Containing a TGF-beta family domain, similar to LEFTYA, and encoded by human LEFTB Gene (TGF-Beta Family), secreted 366-amino acid 41-kD Left-Right Determination Factor B (preproprotein) undergoes cell-specific alternative processing into three different products. Processing may occur at R-X-X-R sites. LEFTB appears required for left-right determination during early presomite development in mammals. It may serve as a feedback inhibitor to restrict the range of nodal signaling during establishment of the axis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26349	Leptin_Receptor	Protein_Hormone_Receptor	Leptin Receptor|HuB219|LEP-R|LEPR|LEPR Protein|OB Receptor|OB-R	Encoded by human LEPR Gene (gp130 Cytokine Receptor Family), five Leptin Receptor isoforms are variously expressed in liver, hypothalamus, heart, small intestine, hematopoietic tissues, choroid plexus, prostate, ovary, lung, and kidney. Isoform E may be soluble. The 1165-amino acid 132.5-kD (precursor) type I membrane protein contains 3 fibronectin III-like domains and is TYR phosphorylated; the cytoplasmic domain appears essential for signal transduction. LEPR appears involved in regulation of fat metabolism through hypothalamic effects, angiogenesis, lymphopoiesis, and possibly reproduction. LEPR appears to activate JAK kinase and STAT3, -5, and -6. LEPR malfunction is associated with diabetes and obesity. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26350	CCNB1_Gene	Cyclin_Gene	CCNB1 Gene|CCNB|CCNB1|CGB1|Cyclin B1 Gene	The protein encoded by this gene is a regulatory protein involved in mitosis. The gene product complexes with p34 (cdc2) to form the maturation-promoting factor (MPF). Two alternative transcripts have been found, a constitutively expressed transcript and a cell cycle-regulated transcript that is expressed predominantly during G2/M phase. The different transcripts result from the use of alternate transcription initiation sites. (from LocusLink, OMIM. Swiss-Prot)
C26351	Galectin-3_Binding_Protein	Ligand_Binding_Protein	Galectin 3 Binding Protein|L3 Antigen|LGALS3BP|LGALS3BP Protein|Lectin, Galactoside-Binding, Soluble, 3 Binding Protein|MAC2-Binding Protein|MAC2BP|Mac-2-Binding Protein|Serum Protein 90K	Widely expressed and encoded by human LGALS3BP Gene (MSR1 Superfamily), 585-amino acid extracellular Galectin 3 Binding Protein contains an N-terminal MSR1 Cys-rich domain and binds LGALS3 via carbohydrate-specific interaction. MAC2BP is a potent stimulator of host immune defense systems, such as NK and LAK cell cytotoxicity, and can induce IL2 cytokine production. Oncogenic transformation, viral infection, or pathogen invasion enhance MAC2BP production. LGALS3BP is elevated in the serum of cancer and HIV patients. (from LocusLink, OMIM, and NCI)
C26352	Galectin-8_Protein	Ligand_Binding_Protein	Galectin 8|GAL-8|LGALS8|LGALS8 Protein|Lectin, Galactoside-Binding, Soluble, 8|PCTA1|PO66 Carbohydrate-Binding Protein|PO66-CBP|Po66 Carbohydrate Binding Protein|Prostate Carcinoma Tumor Antigen|Prostate Carcinoma Tumor Antigen 1	Constitutively and ubiquitously expressed by human LGALS8 Gene (S-Lectin Family), 316-amino acid 35.5-kD extracellular Galectin 8 contains two carbohydrate-binding (recognition) domains (CRDs) and binds to beta galactoside in cell adhesion, cell cycle regulation, inflammation, immunomodulation, apoptosis, and metastasis. Galectin 8 may be involved in activation of various cell types through cross-linkage of cell surface glycoproteins and may be involved in some types of cancer. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26353	Leucine-Rich_Glioma-Inactivated_Protein	Protein_with_Unknown_or_Unclassified_Function	Leucine-Rich Glioma-Inactivated Protein|BA512J3.1|Epitempin 1|LGI1|LGI1 Protein|Leucine-Rich Glioma-Inactivated 1|Leucine-Rich Glioma-Inactivated Protein 1	Predominantly expressed in neural tissues and encoded by human LGI1 Gene, a 557-amino acid 64-kD precursor yields mature 60-kD putative tumor suppressor Leucine-Rich Glioma-Inactivated Protein, containing a putative extracellular N-terminus and hydrophobic transmembrane segment, as well as leucine-rich repeats (LRR) with conserved cysteine-rich flanking sequences. LGI1 shows high similarity in the LRR domain with transmembrane and extracellular receptors and adhesion proteins. Translocation rearrangements of LGI1 reduce or abrogate expression in several glioblastomas and brain tumors. LGI1 mutations appear responsible for autosomal dominant partial epilepsy with auditory features. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26354	LIM_Homeobox_Protein-1	Homeobox_Protein	LIM Homeobox Protein 1|Homeobox Protein LIM-1|LHX1|LHX1 Protein|LIM/Homeobox Protein LHX1|LIM/Homeodomain Transcription Factor 1	Encoded by conserved human LHX1 Gene (LIM/Homeobox Family) and expressed in brain, thymus, and tonsil, 384-404-amino acid 44.5-kD nuclear LIM Homeobox Protein 1 is a putative transcriptional regulatory protein containing two CYS-rich zinc ion-binding LIM domains and a DNA-binding homeobox domain. LIM1 may regulate the head organizer and control differentiation and development of neural and lymphoid cells. LIM1 and LMX1B appear to control lateral column motor axon dorsal/ventral trajectory in the developing limb. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26355	LIM_Homeobox_Protein-2	Homeobox_Protein	LIM Homeobox Protein 2|Homeobox Protein LH-2|LHX2|LHX2 Protein|LIM/Homeobox Protein LHX2|LIM/Homeodomain Transcription Factor 2	Related to 'apterous' (Drosophila) and encoded by human LHX2 Gene (LIM/Homeobox Family), 406-amino acid 44-kD nuclear LIM Homeobox Protein 2 is a putative transcription factor containing two CYS-rich zinc ion-binding LIM domains and a DNA-binding homeobox domain. LIM2 may control differentiation and development of neural and lymphoid cells. Rodent LH2 is expressed in the central nervous system and in immature B- and T-cells. In the pituitary, mouse Lh2 regulates expression of the pituitary glycoprotein hormone alpha subunit. High expression is observed in chronic myelogenous leukemia (CML). (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26356	Hippocalcin	Calcium_Binding_Protein	Hippocalcin|BDR-2|HPCA|HPCA Protein|Neuron Specific Calcium Binding Protein Hippocalcin|p23K	Encoded by human HPCA Gene (Recoverin Subfamily), 192-amino acid 22-kD neuron-specific Hippocalcin is myristoylated, plasma membrane-associated, binds two Ca(2+) ions, and contains the EF-hand Ca(2+)-binding motif. Human amino acid sequence shows complete identity (and 92% nucleotide identity) with rat; it is also identical to mouse hippocalcin. Hippocalcin shows striking similarity to photoreceptor Ca(2+)-sensitive proteins that regulate photosignal transduction. Displaying recoverin activity and a Ca(2+)-dependent inhibition of rhodopsin kinase, it may be involved in the Ca(2+)-dependent regulation of rhodopsin phosphorylation. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26357	DEAD-H_Box_Protein-26	Transmembrane_Protein	DEAD/H Box Protein 26|DDX26|DDX26 Protein|DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 26|DEAD/H BOX 26|EGF Repeat Transmembrane Protein|RNA Helicase HDB|RNA Helicase HDB/DICE1	Encoded by human DDX26 Gene (DEAD Family), the highly conserved candidate tumor suppressor 1687-amino acid 188.5-kD DEAD/H Box Protein 26 contains a vWF type A domain. With a likely important cellular function, DDX26 is expressed in a variety of fetal and adult tissues. DEAD box proteins, characterized by a conserved Asp-Glu-Ala-Asp (DEAD) motif, are putative RNA helicases that alter RNA secondary structure and influence translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on distribution, some family members may be involved in embryogenesis, spermatogenesis, and cellular growth and division. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26358	Array	Conceptual_Entities	Array	An orderly arrangement. (from the American Heritage Dictionary)
C26359	Serving	Conceptual_Entities	Serving	An individual portion of food or drink.
C26360	MAP_Kinase_Gene	Serine-Threonine_Protein_Kinase_Gene	MAP Kinase Gene|ERK|Extracellular Signal-Regulated Kinase Gene|MAPK|Mitogen-Activated Protein Kinase Gene	MAP kinase gene products act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. (LocusLink)
C26364	MAP-Kinase-11	Mitogen-Activated_Protein_Kinase	MAP Kinase 11|MAPK11|Mitogen-Activated Protein Kinase P38-2|Stress-Activated Protein Kinase-2	Encoded by MAPK11 Gene, MAP Kinase 11 is a member of the MAP kinase family, integration points for multiple biochemical signals and involved in a variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAPK11 is most closely related to p38 MAP kinase; both can be activated by proinflammatory cytokines and environment stress. MAPK11 is activated through phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of MAPK11. (NCI)
C26365	MAP-Kinase-10	Mitogen-Activated_Protein_Kinase	MAP Kinase 10|C-Jun N-Terminal Kinase 3|MAP Kinase P49 3F12|MAPK10|Stress Activated Protein Kinase Beta|Stress-Activated Protein Kinase JNK3|c-Jun Kinase 3	The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This protein is a neuronal-specific form of c-Jun N-terminal kinases (JNKs). Through its phosphorylation and nuclear localization, this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated MAP kinase scaffold protein, is found to interact with, and stimulate the phosphorylation of this kinase by MAP kinase kinase 4 (MKK4). Cyclin-dependent kianse 5 can phosphorylate, and inhibit the activity of this kinase, which may be important in preventing neuronal apoptosis. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. (LocusLink)
C26367	MAP-Kinase-12	Mitogen-Activated_Protein_Kinase	MAP Kinase 12|Extracellular Signal-Regulated Kinase 6|MAPK12|Mitogen-Activated Protein Kinase 3|Stress-Activated Protein Kinase 3	Encoded by MAPK12 Gene (MAPK Family), MAP Kinase 12 constitutes a member of the stress-activated protein kinases involved in transduction of extracellular signals. SAPK3 functions as a signal transducer during differentiation of myoblasts to myotubes. (LocusLink)
C26368	MAP-Kinase-13	Mitogen-Activated_Protein_Kinase	MAP Kinase 13|MAP Kinase P38 Delta|MAPK13|Mitogen-Activated Protein Kinase P38 Delta|Stress-Activated Protein Kinase-4	Encoded by MAPK13 Gene (MAPK Family), MAP Kinase 13 is closely related to p38 MAP kinase; both can be activated by proinflammatory cytokines and cellular stress. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. MAP kinase kinases 3 and 6 can phosphorylate and activate MAPK13. Transcription factor ATF2, and microtubule dynamics regulator Stathmin have been shown to be the substrates of this kinase. (NCI)
C26369	MAP-Kinase-14	Mitogen-Activated_Protein_Kinase	MAP Kinase 14|CSAIDS Binding Protein|CSBP|Cytokine Suppressive Anti-Inflammatory Drug Binding Protein|MAP Kinase Mxi2|MAP Kinase p38Alpha|MAPK14|MAX-Interacting Protein 2|Mitogen-Activated Protein Kinase 14|Mitogen-Activated Protein Kinase p38Alpha|SAPK2A|Stress-Activated Protein Kinase 2A|p38 MAP Kinase|p38 MAPK|p38 Mitogen Activated Protein Kinase|p38Alpha EXIP	Expressed in brain, heart, placenta, pancreas, skeletal muscle, lung, liver, and kidney, by human MAPK14 Gene (MAPK Family), the four isoforms (varying by internal segments and C-termini) of (Ser/Thr) Mitogen-Activated Protein Kinase 14 are involved in oxidative/hypoxic/environmental/genotoxic stress, transcription, cell cycle regulation, and apoptosis. Bound to cytoplasmic PTPRR and activated by cell stress, proinflammatory cytokines, LPS, Thr/Tyr phosphorylation by MAP2K3, MAP2K6, and MAP2K4, and autophosphorylation by MAP3K7IP1/TAB1 interaction, p38 MAPK phosphorylates MAPKAPK2, MAPKAPK5, ELK-1, ATF2, MEF2C, MAX, CDC25B, and p53. p38 is inhibited by DUSP1 and CSAID drugs. (NCI)
C26370	MAP-Kinase-4	Mitogen-Activated_Protein_Kinase	MAP Kinase 4|Extracellular Signal-Regulated Kinase 4|MAP Kinase Isoform P63|MAPK4	Highly expressed in heart and brain by human MAPK4 Gene (MAPK Family), 557-aa 63-kDa MAP Kinase 4 is a Ser/Thr protein kinase activated by tyrosine kinase growth factor receptors that translocates to the nucleus to phosphorylate nuclear targets and likely promote entry in the cell cycle. MAPK4 also phosphorylates MAP2. (NCI)
C26371	MAP-Kinase-6	Mitogen-Activated_Protein_Kinase	MAP Kinase 6|Extracellular Signal-Regulated Kinase 3|Extracellular Signal-Regulated Kinase, p97|MAPK6|Protein Kinase, Mitogen-Activated 5|Protein Kinase, Mitogen-Activated 6	Expressed in skeletal muscle, brain, heart, placenta, lung, liver, pancreas, kidney, and fibroblasts by human MAPK6 Gene (MAPK Family), 721-aa 83-kDa nuclear MAP Kinase 6 is a Ser/Thr protein kinase activated by protein phosphorylation cascades that acts as an integration point for multiple biochemical signals and likely promotes entry in the cell cycle. MAPK6 phosphorylates MAP2. (NCI)
C26372	HIF1A_Gene	Protein_Complex_Subunit_Gene	HIF1A Gene|HIF-1alpha|HIF1-Alpha|HIF1A|Hypoxia-Inducible Factor 1, Alpha Subunit (Basic Helix-Loop-Helix Transcription Factor) Gene|MOP1	Induced by hypoxia, growth factors, and cytokines, widely expressed human HIF1A Gene encodes 2 alternative isoforms of cytoplasmic S-nitrosylated 826-aa 93-kDa (phosphorylated) DNA-binding (HRE) bHLH Hypoxia-Inducible Factor 1 Alpha Subunit (HIF1 TF) involved in hypoxic responses and angiogenesis. HIF1 beta is ARNT. HIF1A contains 2 PAS dimerization domains, a PAC domain, and the transactivation domains (NTAD/CTAD) are repressed by an inhibitory domain. HIF1A requires CREBPB/EP300 (via TAZ-1 domains) and is enhanced by NCOA1/NCOA2. APEX activates CTAD and potentiates NCOA1/CREBBP activation. Normoxic Pro-hydroxylation (ODD domain by EGLN1/EGLN2), promoting VHL interaction and ubiquitin degradation, is hypoxically impaired, resulting in stabilization. ARD1 acetylation increases VHL interaction and degradation. Normoxic Asn-hydroxylation by HIF1AN abrogates CREBBP and EP300 interaction preventing transcription. (NCI)
C26373	ARNT_Gene	Transcription_Factor_Gene	ARNT Gene|ARNT|Aryl Hydrocarbon Receptor Nuclear Translocator Gene|Dioxin Receptor, Nuclear Translocator Gene|HIF-1 Beta Gene|HIF-1Beta Gene|HIF-1beta|HIF1-Beta Gene|HIF1B|HIF1B Gene|HIF1Beta|HIF1beta Gene|Hypoxia-Inducible Factor 1 Beta Gene|Hypoxia-Inducible Factor 1, Beta Subunit Gene	The gene product of ARNT is the beta subunit of hypoxia-inducible factor 1, which function as transcription factor.  It also functions as aryl hydrocarbon receptor nuclear translocator upon ligand binding, thus the name ARNT.  ARNT gene contains 22 exons, varying in size from 25 to 214 bp, and spans 65 kb. Splice junctions follow the GT/AG consensus except for intron 11 starting with GC at its 5-prime end. (From LocusLink, OMIM)
C26374	ARNT2_Gene	Transcription_Factor_Gene	ARNT2 Gene|ARNT2|Aryl-Hydrocarbon Receptor Nuclear Translocator 2 Gene|KIAA0307	The ARNT2 gene encodes Aryl Hydrocarbon Receptor Nuclear Translocator 2, a member of a novel transcription factor family consisting of a conserved basic helix-loop-helix (bHLH) structural motif contiguous with a PAS domain. (From LocusLink)
C26375	Growth_Differentiation_Factor-9	Transforming_Growth_Factor-Beta	Growth Differentiation Factor 9|GDF-9 Protein|GDF9|GDF9 Protein	Growth Differentiation Factor 9, encoded by the human GDF9 gene, is a member of the TGF-beta superfamily. This protein interacts with bone morphogenetic protein-15 and Bone morphogenetic protein receptor type II is a receptor for Growth Differentiation Factor-9. Both GDF9 mRNA and protein are abundantly expressed in oocytes of primary follicles in human ovary, suggesting that the GDF9 transcript is translated at this early stage of folliculogenesis. GDF9 is crucial for normal ovarian folliculogenesis and female fertility. GDF9 regulates human folliculogenesis in a manner specific to the ovary. A dysregulation of GDF9 expression may contribute to aberrant folliculogenesis in PCOS and PCO women. (From OMIM, Swiss-Prot and NCI)
C26376	Post-Replication_Modification	DNA_Modification_Process	Post-Replication Modification	Post-Replication Modification involves covalent alteration of DNA after replication, e.g., methylation at either A or C bases within a particular DNA sequence. (NCI)
C26377	DNA_Methylation_Regulation	DNA_Modification_Process	DNA Methylation Regulation	DNA Methylation Regulation involves cellular mechanisms that control covalent addition of methyl groups to specific cytosine residues of a DNA molecule, which typically influence gene expression and other genetic functions.
C26378	MAP-Kinase-7	Mitogen-Activated_Protein_Kinase	MAP Kinase 7|BMK1 Kinase|Extracellular Signal-Regulated Kinase 5|MAPK7	Highly expressed as four alternative transcripts in heart, placenta, lung, kidney, and skeletal muscle by human MAPK7 Gene (MAPK Family), 815-aa 88.6-kDa MAP Kinase 7 is a Ser/Thr kinase specifically activated by MAP2K5 (not MEK1/MEK2) and involved as an integration point for multiple downstream signals of various receptors, including receptor type kinases and GPCRs, in cell proliferation, differentiation, transcription regulation, and development. Autophosphorylated and likely activated by tyrosine and threonine phosphorylation by upstream kinase, MAPK7 translocates to the nucleus in response to extracellular signals and regulates gene expression by phosphorylating and activating target transcription factors. The C-terminus may have an autoregulatory role, and the second Pro-rich region may interact with actin, targeting MAPK7 to specific cell locations. (NCI)
C26379	MAP-Kinase-9	Mitogen-Activated_Protein_Kinase	MAP Kinase 9|C-Jun Kinase 2|C-Jun N-Terminal Kinase 2|Jun Kinase|MAPK9|Stress-Activated Protein Kinase JNK2	Expressed as alpha-1, -2, beta-1, -2 isoforms by human MAPK9 Gene (MAPK Family), MAP Kinase 9 is a stress/cytokine-induced Ser/Thr kinase that acts as an integration point for multiple biochemical signals involved in target transcription factor regulation, such as c-Jun and ATF2. Alpha-1, and 2 bind c-Jun; beta-1 and 2 bind ATF2. JunB and JunD are not substrates for alpha-2. Inhibited by dual specificity phosphatases, and phosphothreonine/tyrosine activated by a Ras-dependent dual specificity MAP2K4/MAP2K7 cascade, MAPK9 mediates immediate-early gene expression. MAPK9 binds scaffolding proteins MAPK8IP1/2/3. MAPK9/UV-induced apoptosis appears related to cytochrome c-mediated cell death. Increased p53 stability in nonstressed cells results from MAPK9 blocked p53 ubiquitination. MAPK9 appears required for T-helper cell differentiation into Th1 cells. (NCI)
C26380	APC-Binding_Protein-EB1	Ligand_Binding_Protein	Microtubule-Associated Protein, RP/EB Family, Member 1|APC-Binding Protein EB1|Adenomatous Polyposis Coli-Binding Protein EB1|MAPRE1	Encoded by human MAPRE1 Gene (MAPRE/RP/EB Family), 268-aa 30-kDa Microtubule-Associated Protein RP/EB Family Member 1 contains a CH domain and a C-terminal domain that binds to APC. In interphase, MAPRE1 localizes to microtubules (growing ends); during mitosis, MAPRE1 is associated with centrosomes and spindle microtubules. MAPRE1 also associates with components of the dynactin complex and the intermediate chain of cytoplasmic dynein. MAPRE1 also interacts with TERF1. MAPRE1 is likely involved in regulation of microtubule structures, microtubule polymerization, spindle function, and chromosome stability. (NCI)
C26381	Neurite_Growth-Promoting_Factor-2	Neurotrophic_Factor	Neurite Growth-Promoting Factor 2|Amphiregulin-Associated Protein|MDK|Midgestation and Kidney Protein|Midkine|Neurite Outgrowth-Promoting Factor 2	NEGF2 is a member of a highly conserved, developmentally regulated human gene family. The gene product exhibits neurite outgrowth-promoting activity and may play a role in nervous system development and/or maintenance. Expression of NEGF2 is predominant only for a short period from approximately one-half to two-thirds of the way through gestation; before and after that, it is barely detectable. The gene codes for a 143-residue protein which is a precursor for a mature protein of 121 amino acids and is 46% homologous with another heparin-binding neurite outgrowth-promoting factor, NEGF1. NEGF2 is also known as midkine. Midkine was first found in differentiating mouse teratocarcinoma cells. It has neurotrophic activities and is mitogenic to certain, but not to all, fibroblast cell lines.(from OMIM)
C26382	Homeobox_Protein-MEIS1	Ligand_Binding_Protein	Homeobox Protein MEIS1|MEIS1|MEIS1 Homolog	Expressed in immunohepatopoietic tissues and in brain by human MEIS1 Gene (TALE/MEIS Family), 390-aa 43-kDa Homeobox Protein MEIS1 contains one homeobox domain, the only conserved motif in the entire protein. Homeobox genes play a crucial role in normal development. Mouse Meis1 regulates Pbx1 protein activity by promoting nuclear import and specifies cell fates and differentiation patterns along the proximodistal limb axis. (NCI)
C26383	Receptor_Tyrosine_Kinase-MERTK	Receptor_Tyrosine_Kinase	Receptor Tyrosine Kinase MerTK|EC 2.7.1.112|MERTK|c-mer Proto-oncogene Tyrosine Kinase	Expressed in monocytes, bone marrow, and tissues of epithelial and reproductive origin by human MERTK Gene (AXL/UFO Family), 999-aa 110-kDa (precursor) Receptor Tyrosine Kinase MERTK contains 2 extracellular N-terminal Ig-like C2-type domains and 2 membrane proximal fibronectin type III domains, a putative transmembrane segment, a tyrosine kinase KWIAIES domain, several N-glycosylation sites, and tyrosine phosphorylation sites. Not expressed in normal B- and T-lymphocytes, MERTK is expressed in numerous neoplastic B-and T-cell lines. MERTK defects cause retinitis pigmentosa. (NCI)
C26384	Growth_Factor_Independence-1B_Protein	Transcription_Factor	Growth Factor Independence-1B|GF11B Protein|GFI1B	Growth Factor Independence-1B, encoded by the human GFI1B gene, is a zinc finger protein. This protein is a transcription factor with specific involvement in the regulation of erythroid cell growth in normal erythropoiesis through modulating erythroid-specific gene expression. The function of GFI1B to modulate transcription depends on promoter context. Human GFI1B expression by Northern blot analysis is highest in bone marrow and fetal liver as well as in the chronic myeloid leukemia cell line K562 with lower levels in other hematopoietic precursor cells. Expression of GFI1B is highly restricted to hematopoietic stem cells, erythroblasts, and megakaryocytes. Its expression does not promote erythroid commitment, but enhances proliferation of immature erythroblasts. The chromosomal region of this gene is translocated to chromosome 22q11 in chronic myeloid leukemia. (From OMIM, PubMed 12351384 and NCI)
C26385	_1q41-q44	Chromosome_Band	1q41-q44	A chromosome band present on 1q
C26386	_15q26	Chromosome_Band	15q26	A chromosome band present on 15q
C26387	Exercise_Pain_Management	Pain_Management_Method	Exercise Pain Management|Exercise	A pain management technique based on improvement of functional ability, strengthening, and maintenance of range of motion.  It is believed that endorphin release during exercise minimizes pain and improves effectiveness of analgesics.
C26388	Milk_Fat_Globule-EGF_Factor-8_Protein	Ligand_Binding_Protein	Milk Fat Globule-EGF Factor 8 Protein|Breast Epithelial Antigen BA46|Lactadherin Precursor|MFGE8	Expressed in mammary epithelia and activated macrophages by human MFGE8 Gene, 387-aa 43-kDa (precursor) Milk Fat Globule-EGF Factor 8 Protein is a multidomain cell surface (and secreted) protein that contains an EGF-like domain, C-terminal F5/8 type C domains, and the cell adhesion tripeptide RGD. MFGE8 recognizes aminophospholipids (phosphatidylserine) and binds to cells via its RGD motif; MFGE8 binds strongly to cells expressing alpha-V-beta-3 integrin. Expressed by activated macrophages, MFGE8 specifically binds to apoptotic cells and appears to promote macrophage phagocytosis of apoptotic cells. MFGE8 is overexpressed in several carcinomas. (NCI)
C26389	GDNF_Family_Receptor_Alpha-2	Cell_Surface_Receptor	GDNF Family Receptor Alpha 2|GDNF Family Receptor Alpha-2|GDNF Receptor Beta|GDNFR-Beta|GDNFRB|GFR-Alpha 2|GFRA2|GFRA2 Protein|Glial Cell Line Derived Neurotrophic Factor Receptor, Beta|Glial Cell Line-Derived Neurotrophic Factor Receptor Beta|NRTNR-ALPHA|NTNR-Alpha|NTNRA|Neurturin Receptor Alpha|PI-Linked Cell-Surface Accessory Protein|RET Ligand 2|RETL2|TGF-Beta Related Neurotrophic Factor Receptor 2|TRN Receptor, GPI-Anchored|TRNR2	GDNF Family Receptor Alpha 2, encoded by the human GFRA2 gene, is a member of the Glial Cell Line-Derived Neurotrophic Factor (GDNF) Receptor family. GDNF and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. GFRA2 is required for the development of the myenteric nerve plexus. This protein is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This receptor acts preferentially as a receptor for NTN compared to its other family member, GDNF Family Receptor Alpha 1. Two alternatively spliced transcript variants, long and short, have been described for this gene but their full length nature is not known. The short form is found in brain and placenta. This gene is a candidate gene for RET-associated diseases. (From LocusLink, OMIM, Swiss-Prot and NCI)
C26390	Mouse_Disorder_by_Site	Mouse_Pathologic_Diagnoses	Mouse Disorder by Site|Disorder by Site
C26391	Mouse_Cardiovascular_System_Disorder	Mouse_Disorder_by_Site	Mouse Cardiovascular System Disorder|Mouse Cardiovascular Disorder
C26392	Mouse_Connective_and_Soft_Tissue_Disorder	Mouse_Disorder_by_Site	Mouse Connective and Soft Tissue Disorder|Connective and Soft Tissue Disorder
C26393	Mouse_Digestive_System_Disorder	Mouse_Disorder_by_Site	Mouse Digestive System Disorder|Digestive System Disorder
C26394	Mouse_Endocrine_Gland_System_Disorder	Mouse_Disorder_by_Site	Mouse Endocrine Gland System Disorder|Endocrine Gland System Disorder
C26395	Mouse_Urinary_Tract_Disorder	Mouse_Disorder_by_Site	Mouse Urinary Tract Disorder|Urinary Tract Disorder
C26396	Mouse_Reproductive_System_Disorder	Mouse_Disorder_by_Site	Mouse Reproductive System Disorder|Reproductive System Disorder
C26397	Mouse_Female_Reproductive_System_Disorder	Mouse_Reproductive_System_Disorder	Mouse Female Reproductive System Disorder|Female Reproductive System Disorder
C26398	Protein_Splicing	Protein_Sequence_Alteration	Protein Splicing	Excision of in-frame internal protein sequences (inteins) of a precursor protein, coupled with ligation of the flanking sequences (exteins). Protein splicing is an autocatalytic reaction and results in the production of two proteins from a single primary translation product: the intein and the mature protein. (On-line Medical Dictionary)
C26399	Mouse_Male_Reproductive_System_Disorder	Mouse_Reproductive_System_Disorder	Mouse Male Reproductive System Disorder|Male Reproductive System Disorder
C26400	Mouse_Prostate_Disorder	Mouse_Male_Reproductive_System_Disorder	Mouse Prostate Disorder|Prostate Disorder
C26401	Mouse_Head_and_Neck_Disorder	Mouse_Disorder_by_Site	Mouse Head and Neck Disorder|Head and Neck Disorder
C26402	Mouse_Hematologic_Disorder	Mouse_Disorder_by_Site	Mouse Hematologic Disorder|Hematologic Disorder
C26403	Mouse_Mammary_Gland_Disorder	Mouse_Disorder_by_Site	Mouse Mammary Gland Disorder|Mammary Gland Disorder
C26404	Mouse_Skin_Disorder	Mouse_Disorder_by_Site	Mouse Skin Disorder|Skin Disorder	An alteration in the normal structure of the skin relative to normal for a specific age, mouse strain, and skin site.
C26405	Mouse_Nervous_System_Disorder	Mouse_Disorder_by_Site	Mouse Nervous System Disorder|Nervous System Disorder
C26406	Mouse_Respiratory_System_Disorder	Mouse_Disorder_by_Site	Mouse Respiratory System Disorder|Respiratory System Disorder
C26407	Mouse_Skeletal_System_Disorder	Mouse_Disorder_by_Site	Mouse Skeletal System Disorder|Skeletal System Disorder
C26409	Body_Fluids_and_Substances_MMHCC	Murine_Tissue_Type	Body Fluids and Substances (MMHCC)|Body Fluids and Substances|Fluids
C26410	Urine_MMHCC	Body_Fluids_and_Substances_MMHCC	Urine (MMHCC)|Urine
C26411	Pleural_Fluid_MMHCC	Body_Fluids_and_Substances_MMHCC	Pleural Fluid (MMHCC)|Pleural Fluid
C26412	Mucus_MMHCC	Body_Fluids_and_Substances_MMHCC	Mucus (MMHCC)|Mucus
C26413	Sebum_MMHCC	Body_Fluids_and_Substances_MMHCC	Sebum (MMHCC)|Sebum
C26414	Sputum_MMHCC	Body_Fluids_and_Substances_MMHCC	Sputum (MMHCC)|Sputum
C26415	Stool_MMHCC	Body_Fluids_and_Substances_MMHCC	Stool (MMHCC)|Stool
C26416	Discharge_MMHCC	Body_Fluids_and_Substances_MMHCC	Discharge (MMHCC)|Discharge
C26417	Exudate_MMHCC	Body_Fluids_and_Substances_MMHCC	Exudate (MMHCC)|Exudate
C26418	T-Cell_Receptor_Beta_Locus	T-Cell_Receptor_Gene	T-Cell Receptor Beta Locus|T-Cell Receptor Beta Gene|TCRB|TRB	This region represents the germline organization of the T cell receptor beta locus. The beta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the beta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase.  Chromosomal abnormalities involving the T-cell receptor beta locus have been associated with T-cell lymphomas. (from LocusLink)
C26419	T-Cell_Receptor_Alpha_Locus	T-Cell_Receptor_Gene	T-Cell Receptor Alpha Locus|T-Cell Receptor Alpha Gene|TCRA|TRA	This region represents the germline organization of the T cell receptor alpha locus. The alpha locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the alpha chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. (from LocusLink)
C26420	T-Cell_Receptor_Delta_Locus	T-Cell_Receptor_Gene	T-Cell Receptor Delta Locus|T-Cell Receptor Delta Gene|TCRD|TRD	This region represents the germline organization of the T cell receptordelta locus. The delta locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During T cell development, the delta chain is synthesized by a recombination event at the DNA level joining a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. (from LocusLink)
C26421	T-Cell_Receptor_Gamma_Locus	T-Cell_Receptor_Gene	T-Cell Receptor Gamma Locus|T-Cell Receptor Gamma Gene|TCRG|TRG	This region represents the germline organization of the T cell receptor gamma locus. The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the gamma chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase. (from LocusLink)
C26422	Immunoglobulin_Heavy_Locus	Immunoglobulin_Family_Gene	Immunoglobulin Heavy Locus|IGH|Immunoglobulin Heavy Chain Gene|Immunoglobulin Heavy Chain Locus|Immunoglobulin Heavy Gene	This region represents the germline organization of the immunoglobulin heavy chain locus. The locus includes V (variable), J (joining), diversity (D), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a D segment with a J segment; a V segment is then joined to the D-J gene. The C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several D and J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink)
C26423	Immunoglobulin_Lambda_Locus	Immunoglobulin_Family_Gene	Immunoglobulin Lambda Locus|IGL|Immunoglobulin Lambda Gene|Lambda Light Chain Gene	This region represents the germline organization of the lambda light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink)
C26424	_22q11_1-q11_2	Chromosome_Band	22q11.1-q11.2	A chromosome band present on 22q
C26425	Immunoglobulin_Kappa_Locus	Immunoglobulin_Family_Gene	Immunoglobulin Kappa Locus|IGK|Immunoglobulin Kappa Gene|Kappa Light Chain Gene	This region represents the germline organization of the kappa light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink)
C26426	T-Cell_Receptor_Alpha_Chain	Protein_Complex_Subunit	T-Cell Receptor Alpha Chain|T-Cell Receptor Alpha|TCRA|TRA	One component of the alpha-beta T-cell receptor. Encoded by a locus on chromosome 14. Somatic recombination results in formation of the active gene.
C26427	T-Cell_Receptor_Beta_Chain	Protein_Complex_Subunit	T-Cell Receptor Beta Chain|T-Cell Receptor Beta|TCRB|TRB	One component of the alpha-beta T-cell receptor. Encoded by a locus on chromosome 7. Somatic recombination results in formation of the active gene.
C26428	T-Cell_Receptor_Gamma_Chain	Protein_Complex_Subunit	T-Cell Receptor Gamma Chain|T-Cell Receptor Gamma|TCRG|TRG	One component of the gamma-delta T-cell receptor. Encoded by a locus on chromosome 7. Somatic recombination results in formation of the active gene.
C26429	T-Cell_Receptor_Delta_Chain	Protein_Complex_Subunit	T-Cell Receptor Delta Chain|T-Cell Receptor Delta|TCRD|TRD	One component of the gamma-delta T-cell receptor. Encoded by a locus on chromosome 14. Somatic recombination results in formation of the active gene.
C26430	NFKBIA_Gene	Signaling_Pathway_Gene	NFKBIA Gene|IKBA|MAD-3|NFKBI|NFKBIA|Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, Alpha Gene	Glucocorticoid-inducible 6-exon 3.7-kb human NFKBIA Gene (NFKBI Family) encodes 317-aa 36-kDa cytoplasmic I-Kappa-B-Alpha, containing 5 ANK repeats that interact with p65 RELA C-terminal REL homology regions. By complexing with and trapping NF-Kappa-B in the cytoplasm, unphosphorylated NFKBIA inhibits NFKB target gene transcription in cell adhesion, immune and proinflammatory responses, apoptosis, differentiation, and growth. NFKBIA tyrosine phosphorylation leads to dissociation from NFKB, disabling inhibition of NFKB DNA-binding. Stimulus-dependent IKBKA/IKBKB serine phosphorylation of NFKBIA results in polyubiquitination and rapid degradation via the ubiquitin system. (NCI)
C26431	Coronavirus	ssRNA_Virus_plus_Strand	Coronavirus
C26432	GLTSCR1_Protein	Protein_with_Unknown_or_Unclassified_Function	Glioma Tumor Suppressor Candidate Region Gene 1 Protein|GLTSCR1|GLTSCR1 Protein	Glioma Tumor Suppressor Candidate Region Gene 1 Protein is encoded by the human GLTSCR1 gene. This protein is expressed at moderate levels in heart, brain, placenta, skeletal muscle, and pancreas, and at lower levels in lung, liver, and kidney. Mutation analysis of the transcripts in the gene region in diffuse gliomas with 19q deletions revealed no tumor-specific mutations. However, a marker in GLTSCR1, presumably separated from RAI by several million bases, supplements the most significant marker in RAI in separating cases of basal cell carcinoma (BCC) from controls, which may suggest the presence of an independent, risk-modulating variation in this second gene region. (From OMIM, Swiss-Prot, PubMed 12117772 and NCI)
C26433	GLTSCR2-p60_Protein	Nuclear_Protein	Glioma Tumor Suppressor Candidate Region Gene 2 Protein|GLTSCR2|GLTSCR2 Protein|p60	Expressed in heart, pancreas, placenta, liver, skeletal muscle, kidney, brain, and lung by human GLTSCR2 Gene (GLTSCR2 Family), 478-aa 54-kDa nuclear Glioma Tumor Suppressor Candidate Region Gene 2 Protein interacts with HSV-1 early proteins ICP22 and ICP0. GLTSCR2 function is unknown. (NCI)
C26435	_4q25-q31	Chromosome_Band	4q25-q31	A chromosome band present on 4q
C26436	_5q12	Chromosome_Band	5q12	A chromosome band present on 5q
C26437	_8q22_1	Chromosome_Band	8q22.1	A chromosome band present on 8q
C26439	_15q24	Chromosome_Band	15q24	A chromosome band present on 15q
C26440	Conation	Mental_Process	Conation	The conscious tendency to act, usually an aspect of mental process.
C26441	MDX-060_Monoclonal_Antibody	Monoclonal_Antibody_for_Clinical_Diagnosis	Monoclonal Antibody MDX-060	A monoclonal antibody with potential antineoplastic activity.  MDX-060 is a fully humanized antibody that targets CD30, a member of the tumor necrosis factor receptor superfamily found on activated lymphocytes.  CD30 is over-expressed in various lymphoproliferative disorders, Hodgkin's disease and other lymphomas, and other cancers. (NCI04)
C26442	I_131_Monoclonal_Antibody_CC49	Radioimmunoconjugate	I 131 Monoclonal Antibody CC49|Iodine I 131 Monoclonal Antibody CC49	A radioimmunoconjugate consisting of CC49, a monoclonal antibody directed against the tumor associated glycoprotein 72 (TAG-72), linked to a beta- and gamma-emitting radioisotope iodine 131 (I 131).  I 131 monoclonal antibody CC49 binds to tumor cells that express TAG-72, delivering beta and gamma particle radiation allowing imaging and treatment of cells expressing TAG-72.
C26443	_14q21-q24	Chromosome_Band	14q21-q24	A chromosome band present on 14q
C26444	Adenovirus_5-Tumor_Necrosis_Factor_Alpha	Viral_Vector-Gene_Complex	Adenovirus 5-Tumor Necrosis Factor Alpha|Ad 5-TNF Alpha	A recombinant agent consisting of a genetically-modified adenovirus 5 vector encoding the protein cytokine tumor necrosis factor (TNF) alpha.  TNF exhibits potent anti-tumor cytolytic properties; the adenovirus 5 vector efficiently infects tumor cells, delivering tumor-specific TNF. (NCI04)
C26445	Autologous_Dendritic_Cell-Adenovirus_P53_Vaccine	Dendritic_Cell_Tumor_Peptide_Vaccine	Autologous Dendritic Cell-Adenovirus P53 Vaccine	An autologous vaccine composed of dendritic cells (DC) that have been transduced with a p53 tumor suppressor gene-modified virus. When the autologous dendritic cell-adenovirus p53 vaccine is administered, the host cytotoxic T lymphocytes (CTL) are directed against p53-positive tumor cells, which may result in tumor cell death and decreased tumor growth. (NCI04)
C26446	Dendritic_Cell-Autologous_Lung_Tumor_Vaccine	Autologous_Cell_Vaccine	Dendritic Cell-Autologous Lung Tumor Vaccine	A cancer vaccine consisting of lymphocytes harvested from a patient with lung cancer and induced to become antigen-presenting cells (APCs) known as dendritic cells.  The dendritic cells are transduced with the gene encoding an antigen specific to the patient's cancer and then returned to the patient.  In the host, the altered cells stimulate the immune system to mount a primary T cell response against lung tumor cells expressing the target antigen.  Dendritic cell-autologous lung tumor vaccines have been investigated for use in cancer immunotherapy. (NCI04)
C26447	IDEC-114_Monoclonal_Antibody	Monoclonal_Antibody	Monoclonal Antibody IDEC-114|Galiximab|anti-B7-1|anti-CD80 Antibody	A humanized IgG1 monoclonal antibody directed against CD80, the natural ligand for the T-cell antigen CD28 which mediates T-cell and B-cell adhesion. CD80 is expressed on activated B-cells and gamma-interferon-stimulated monocytes and is often expressed at low levels on the surfaces of follicular lymphoma cells and other lymphoid malignancies. IDEC-114 monoclonal antibody binds to CD80 expressed on the cell surfaces of follicular lymphomas, resulting in antibody-dependent cell-mediated cytotoxicity (ADCC). (NCI04)
C26448	IDEC-152_Monoclonal_Antibody	Monoclonal_Antibody	Monoclonal Antibody IDEC-152|Lumiliximab|anti-CD23 Antibody|p5E8	IDEC-152 was developed to decrease the body's response to allergens, thereby affecting diseases related to asthma and allergic disorders. This monoclonal antibody binds to the CD23 receptor, by which IDEC-152 may favorably influence asthma through its selective regulation of IgE production and its inhibition of other inflammatory pathways.(NCI)
C26449	Monoclonal_Antibody_ACA125_Anti-Idiotype_Vaccine	Anti-Idiotype_Vaccine	Monoclonal Antibody ACA125 Anti-Idiotype Vaccine	A murine immunoglobulin G1 (IgG1) monoclonal anti-idiotype antibody (ACA125).  Vaccination with monoclonal antibody ACA125 anti-idiotype vaccine stimulates the host immune system to mount an antibody response and subsequent antibody-dependent cell-mediated cytotoxicity response against CA125 positive tumor cells, thereby decreasing tumor growth. (NCI04)
C26450	Monoclonal_Antibody_GD2_Anti-Idiotype_Vaccine	Anti-Idiotype_Vaccine	Monoclonal Antibody GD2 Anti-Idiotype Vaccine	A class of vaccines that consist of anti-idiotype monoclonal antibodies against the tumor-associated antigen disialoganglioside GD2 with potential antineoplastic activity.  Vaccination with a monoclonal antibody GD2 anti-idiotype vaccine produces an immunoglobulin response against GD2 with subsequent destruction of GD2 positive tumor cells via antibody-dependent cellular cytotoxicity (ADCC).  GD2 is overexpressed in melanoma, neuroblastoma, soft tissue sarcoma, and small cell carcinoma of the lung. (NCI04)
C26451	Anthraquinone	Pesticide	Anthraquinone|9,10-Anthracenedione|9,10-Anthraquinone|9,10-Dioxoanthracene|ANTHRAQUINONE|Anthradione|EPA Pesticide Chemical Code 122701|Morkit	A polycyclic aromatic hydrocarbon derived from anthracene or pthalic anhydride.  Anthraquinone is used in the manufacture of dyes, in the textile and pulp industries, and as a bird repellant. (NCI)
C26453	Comedo	Disease_Modifier	Comedo	Having a black or dark core or plug.
C26454	Dopaminergic_Cell	Neuron	Dopaminergic Cell	Nerve cells that employ dopamine as their neurotransmitter.
C26456	Luminal	Disease_Modifier	Luminal	Luminal; relating to the lumen of a blood vessel or other tubular structure. (On-line Medical Dictionary)
C26457	Mixed_normal_and_tumor	Disease_Modifier	Mixed (normal and tumor)|Mixed	Mixed; being composed of a combination of normal and tumor cells.
C26458	Intraductal_Hyperplasia	Hyperplasia	Intraductal Hyperplasia|Ductal Hyperplasia
C26459	Uncharacterized_Histology	Disease_Modifier	Uncharacterized Histology
C26460	Animal_Cap	Experimental_Organism_Anatomical_Concepts	Animal Cap	Pigmented animal hemisphere of the amphibian blastula.
C26461	Dorsal_Lip	Experimental_Organism_Anatomical_Concepts	Dorsal Lip	Site of initiation of gastrulation in the amphibian embryo. The dorsal lip, which forms at the site of the gray crescent, forms the dorsal margin of the blastopore.
C26462	Endomesoderm	Experimental_Organism_Anatomical_Concepts	Endomesoderm	Endoderm and mesoderm are initially specified as a bipotential anlage called the endomesoderm. This bipotential layer is subsequently segregated into endoderm and mesoderm.
C26463	Fovea_Centralis	Eye_Part	Fovea Centralis|Fovea	Area consisting of a small depression in the retina containing only cones and where vision is most acute.
C26464	Macula	Other_Anatomic_Concept	Macula
C26465	Corpus_Luteum	Female_Reproductive_System_Part	Corpus Luteum	Yellow endocrine tissue that forms in a ruptured Graafian follicle following the release of an ovum.
C26467	Mesonephros	Other_Embryologic_Structure	Mesonephros|Wolffian Body	The middle one of the three pairs of embryonic renal organs developed in most vertebrates; its duct system is retained in the male as the epididymis and ductus deferens.
C26468	Vesicular_Gland	Retired_Concepts	Vesicular Gland
C26469	Mesonephric_Duct	Other_Embryologic_Structure	Mesonephric Duct|Wolffian Duct	A duct in the embryo draining the mesonephric tubules.
C26470	Maxilla	Irregular_Bone	Maxilla	The upper jawbone in vertebrates: it is fused to the cranium.
C26471	_2q21_1	Chromosome_Band	2q21.1	A chromosome band present on 2q
C26472	_7q31_1-q31_3	Chromosome_Band	7q31.1-q31.3	A chromosome band present on 7q
C26473	_12p13_2-p12_3	Chromosome_Band	12p13.2-p12.3	A chromosome band present on 12p
C26474	Stratifin	Adaptor_Signaling_Protein	Stratifin|14-3-3 Sigma|Epithelial Cell Marker Protein 1|SFN	Stratifin was first identified as an epithelial cell antigen (HME-1) exclusively expressed in epithelia.  The protein is a putative cytoplasmic, p53-regulated homodimeric inhibitor of G2/M progression that is over expressed in squamous cell carcinoma of the head and neck.  The gene is a member of a large 14-3-3 gene family.
C26475	_17q24_3	Chromosome_Band	17q24.3	A chromosome band present on 17q
C26476	Transforming_Acidic_Coiled-Coil_Containing_Protein-2	Protein_with_Unknown_or_Unclassified_Function	Transforming Acidic Coiled-Coil-Containing Protein 2|AZU-1 Protein|Acidic Coiled-Coil Protein 2|Anti Zuai-1 Protein|TACC2|TACC2 Protein|Transforming, Acidic Coiled-Coil Containing Protein 2|Transforming, Acidic Coiled-Coil-Containing Protein 2	Cell culture studies demonstrate that TACC2 interacts with GAS41 and the SWI/SNF chromatin remodeling complex. This suggests that defects in TACC2 expression may affect gene regulation, thus contributing to the pathogenesis of some tumors. (from Genomics 2003;81:192-201)
C26477	NKRP1A_Protein	Immunoprotein	NKRP1A Protein|CD161|KLRB1|Killer Cell Lectin-Like Receptor Subfamily B, Member 1|Killer Cell Lectin-Like Receptor Subfamily B, Member 1 Protein|NKR|NKR-P1|NKR-P1A|hNKR-P1A	Encoded by human KLRB1 Gene (C-Type Lectin Superfamily, NKRP1 Family) and preferentially expressed by natural killer lymphocytes and some peripheral T-cells, the type II membrane NKRP1A Protein (external C-terminus) contains a 158-amino acid extracellular domain with C-type lectin motifs, a 29-amino acid transmembrane domain, and a 38-amino acid cytoplasmic domain. C-type lectins, including NKRP1 glycoproteins, may regulate NK cell function. NKRP1A protein is 46% identical to rat and mouse NKRP1, and 26% identical to human NKG2A. (from LocusLink, OMIM, and NCI)
C26478	CD94_Antigen	Cell_Surface_Receptor	CD94 Antigen|CD94|KLRD1|KLRD1 Protein|KP43|Killer Cell Lectin-Like Receptor Subfamily D, Member 1|Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Isoforms 1, 2|Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Protein|NK Cell Receptor|Natural Killer Cell Antigen CD94|Natural Killer Cells Antigen CD94	Preferentially expressed in NK lymphocytes, CD94 Antigen (179-amino acid, 20.5-kD CD94-A and 148-amino acid CD94 ALT) is encoded by KLRD1 Gene (C-Lectin Family) and may regulate NK cell function. A type II membrane protein (external C-terminus), CD94 contains a 147-amino acid extracellular domain with C-type lectin motifs, a 26-amino acid transmembrane domain, and a 7-amino acid cytoplasmic domain (absent in CD94 ALT). CD94 forms disulfide-bonded heterodimers with NKG2A, NKG2C, and NKG2E. Nonclassical MHC HLA-E protein ligand binds to CD94/NKG2A, CD94/NKG2B, and CD94/NKG2C NK cell receptors. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26479	MADD_Protein	Adaptor_Signaling_Protein	MADD Protein|Differentially Expressed in Normal and Neoplastic Cells Protein|Insulinoma-Glucagonoma Protein 20|MADD|MAP Kinase-Activating Death Domain Protein|MAP-Kinase Activating Death Domain-Containing Protein	Encoded by MADD Gene, MADD Protein Isoforms A-G are expressed in adult testis, ovary, brain, heart, and fetal brain and kidney. The 1588-amino acid 176.6-kD isoform D is full-length. Most variants involve 2-4 stretches of 18-43 amino acids in the central region. Isoforms F and G have a different C-terminus. Containing a C-terminal death domain, RGD motif, and a leucine zipper-like motif, SER- and LEU-rich membrane-bound MADD adaptor protein interacts with TNFR1 death domain to propagate apoptotic signaling. MADD can activate ERK2 and JNK1 MAP kinases and induce phosphorylation of Phospholipase A2. MADD appears to link TNFR1 with MAP kinase activation and arachidonic acid release. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26480	SMAD2_Protein	Adaptor_Signaling_Protein|Transcription_Factor	SMAD2 Protein|JV18-1|MAD (Mothers Against Decapentaplegic, Drosophila) Homolog 2 Protein|MAD, Mothers Against Decapentaplegic Homolog 2 Protein|MAD-Related Protein 2|MADH2|Mothers Against DPP Homolog 2 Protein|Mothers Against Decapentaplegic Homolog 2 Protein|Mothers Against Decapentaplegic, Drosophila, Homolog 2 Protein|SMA- and MAD-Related Protein 2|SMAD2|hMAD-2|hSMAD2	Encoded by MADH2 Gene (SMAD Family), ubiquitous 438/467-aa 52-kD SMAD2, containing a DWA/MH1 and DWB/MH2 domain, mediates Activin, TGFB, and BMP receptor Ser/Thr kinase cell growth/differentiation regulation. Retained by cytoplasmic SARA, SMAD2/SMAD3 are phosphorylated on conserved C-terminal MH2 docking SER-X-SERs by activated receptor. SMAD2/SMAD3 oligomerize with nuclear SMAD4, disrupting SNON/SMAD4 repressors. SMAD3 causes SNON degradation. SMAD2/SMAD4 activate target promoters. TGFBR activity maintains nuclear SMADs and increases feedback SNON expression. SMAD2 interacts with FAST-1/-2, TGIF, PEBP2-A, CBP, p300, c-SKI, NUP214, NUP153, and SMURF2. MADR2 mutations may disrupt growth inhibition. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26481	SMAD6_Protein	Adaptor_Signaling_Protein	SMAD6 Protein|MAD, Mothers Against Decapentaplegic Homolog 6 Protein|MADH6|Mothers Against DPP Homolog 6 Protein|Mothers Against Decapentaplegic Homolog 6 Protein|Mothers Against Decapentaplegic, Drosophila, Homolog 6 Protein|SMA- and MAD-Related Protein 6|SMAD6|hSMAD6	Encoded by MADH6 Gene (SMAD Family), ubiquitous (predominantly vascular endothelium) SMAD6 Protein Isoforms A (496-aa 53.5-kD) and B (235-aa) act similar to other MAD-proteins as second messengers distal to TGFBRs and contain an N-terminal DWA/MH1 domain and a C-terminal DWB/MH2 domain. An inhibitory SMAD phosphorylated by type 1 receptor kinase, SMAD6 acts as an antagonist of TGF-beta type 1 receptor signaling. A selective inhibitor of BMPs signaling; SMAD6 competes with SMAD4 for receptor-activated SMAD1. SMAD6 interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8, and HOXC9. MADH6 and MADH7 form complexes. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26482	SMAD7_Protein	Adaptor_Signaling_Protein	SMAD7 Protein|MAD (Mothers Against Decapentaplegic, Drosophila) Homolog 7 Protein|MADH7|Mothers Against DPP Homolog 7 Protein|Mothers Against Decapentaplegic Homolog 7 Protein|Mothers Against Decapentaplegic, Drosophila, Homolog 7 Protein|SMA- and MAD-Related Protein 7|hSMAD7	Encoded by MADH7 Gene (SMAD Family) and induced by TGF-beta and IFNG, ubiquitous (lung, vascular endothelium highest) 426-amino acid SMAD7 Protein is an inhibitory Activin/TGFBR1 signaling component containing DWA/MH1 and DWB/MH2 domains. SMAD7 lacks C-terminal phosphorylation sites of other MAD proteins, suggesting distinct regulation. Adaptor SMAD7 constitutively recruits nuclear E3 ubiquitin ligase SMURF2 to TGFBR complexes preventing SMAD2 access and causing proteasomal and lysosomal receptor degradation. SMAD7-expressing cells are susceptible to apoptosis induced by TGFB, TNFA, serum withdrawal, or loss of cell adhesion. SMAD7 decreases NFKB activity, promoting apoptosis. RAS suppresses SMAD7 inhibition of NFKB and potentiation of apoptosis. MADH7 and MADH6 form complexes. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26483	SARA_Protein	Adaptor_Signaling_Protein	SARA Protein|MAD (Mothers Against Decapentaplegic, Drosophila) Homolog Interacting Protein, Receptor Activation Anchor|MADH-Interacting Protein|MADHIP|Mothers Against Decapentaplegic Homolog Interacting Protein|NSP|Novel Serine Protease|Receptor Activation Anchor Protein|SMAD Anchor for Receptor Activation|hSARA	Encoded by MADHIP Gene, ubiquitous cytoplasmic SARA contains a FYVE domain zinc finger, seen in signaling molecules and required for SARA localization but not SMAD interaction. Able to bind PI-3 phosphate, SARA recruits SMAD2/3 to TGFBR. The SMAD binding domain (SBD) of SARA interacts with the SMAD2/3 MH2 domain; the C-terminal domain interacts with TGFBR. SMAD2/SMAD3 phosphorylation induces SARA dissociation, SMAD2/SMAD4 formation, and SMAD nuclear translocation. Alternate isoforms represent full-length (1425-aa, 156-kD) or truncated protein (1210-aa and 762-aa). Disruption of MADHIP appears to be involved in Alzheimer's disease. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26484	NRAGE_Protein	Apoptosis_Promoter|Cell_Cycle_Protein	NRAGE Protein|MAGE-D1 Antigen|MAGED1|Melanoma-Associated Antigen D1|PRO2292|Urotrophin Receptor-Interacting MAGE Homolog Protein	Encoded by MAGED1 Gene (MAGE Family), ubiquitous 778-amino acid 86-kD cytoplasmic NRAGE Protein contains a 200-amino acid MAGE homology domain. NRAGE appears to shift from cytoplasm to plasma membrane upon NGF stimulation to interact with p75NTR. NRAGE antagonizes p75NTR association with TRKA, inhibits cell cycle progression, and facilitates p75NTR-mediated apoptosis. NRAGE may regulate the function of DLX family members. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26485	MKK6_Protein	Mitogen-Activated_Protein_Kinase|Signaling_Protein	MKK6 Protein|Dual Specificity Mitogen-Activated Protein Kinase Kinase 6|MAP Kinase Kinase 6|MAP2K6|MAPK/ERK Kinase 6|MAPKK6|Mitogen-Activated Protein Kinase Kinase 6|Protein Kinase, Mitogen-Activated, Kinase 6|SAPKK3	Encoded by MAP2K6 Gene (MAP2K Family), which is activated by UV and osmotic shock, 278-aa MKK6 is expressed in skeletal muscle while 334-aa 37.5-kD MKK6B (longer at the N-terminus) is enriched in heart, skeletal muscle, pancreas, and liver. Tissue-specific splicing may control of MKK6 expression. MKK6 is about 80% identical to MKK3 and 40% identical to MKK4. Probably activated by Ser/Thr phosphorylation, MKK6 Thr/Tyr phosphorylates p38-MAPK exclusively in response to inflammatory cytokines or environmental stress, inducing cell cycle arrest, transcription activation, and apoptosis. Calcium influx triggers the MKK6/p38-MAPK cascade; p38-MAPK activates MEF2s that regulate expression of genes critical for cell survival. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26486	MEKK1_Protein	E3_Ubiquitin_Ligase|Mitogen-Activated_Protein_Kinase|Signaling_Protein	MEKK1 Protein|MAP3K1|MAPK/ERK Kinase Kinase 1|MEK Kinase|MEK Kinase 1|Mitogen-Activated Kinase Kinase Kinase 1|Mitogen-Activated Protein Kinase Kinase Kinase 1	Encoded by MAP3K1 Gene (MAP3K Family), MEKK1 Protein is pivotal in the Ser/Thr phosphorylation network that integrates cellular responses to mitogenic and metabolic stimuli. IFNG induces MEKK1 expression. An efficient activator of the JNK cascade, MEKK1 can phosphorylate MEK1/MEK2, which activate MAPKs. The PHD domain of MEKK1, a RING-type zinc finger, exhibits E3 ubiquitin ligase activity toward ERK2. Thus, MEKK1 functions as both an upstream activator of ERK and JNK through its kinase domain and as an E3 ligase through its PHD domain, decreasing ERK1/ERK2 activity. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26487	Serine-Threonine_Protein_Kinase-NIK	Mitogen-Activated_Protein_Kinase|Signaling_Protein	Serine/Threonine Protein Kinase NIK|HSNIK|MAP3K14|MAP3K14 Protein|Mitogen-Activated Protein Kinase Kinase Kinase 14|NFKB-Inducing Kinase|NIK	Encoded by MAP3K14 Gene (MAP3K Family) and expressed in small intestine, spleen, thymus, peripheral leukocytes, testis, prostate, ovary, and colon, autophosphorylated 947-amino acid 104-kD cytoplasmic Ser/Thr Protein Kinase NIK is involved in NFKB activation. NIK selectively activates NFKB cascades of TNF/NGF receptors and IL1R type-I. TNFA acts through TRAF2; IL1 acts through IRAK1 and TRAF6. LTBR and CD95 also act through NIK. NIK appears to bind TRAFs 2, 5, and 6, IKKA, and NFKB2/p100. Binding to TRAF2 involves the TRAF2 N- and C-terminal regions. NIK induces NFKB2/p100 processing, degradation of phosphoserine-induced ubiquitinated destruction of IKBA, and release of cytoplasmic NFKB for nuclear translocation and kappa-B DNA-mediated gene expression.  (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26488	TAK1_Protein	Mitogen-Activated_Protein_Kinase|Signaling_Protein	TAK1 Protein|MAP3K7|Mitogen-Activated Protein Kinase Kinase Kinase 7|TGF-Beta Activated Kinase 1|TGF1A-D|Transforming Growth Factor-Beta-Activated Kinase 1	Encoded by MAP3K7 Gene (MAP3K Family), ubiquitous TAK1 Protein isoforms A, B (606-aa, 67.2-kD), C, and D regulate transcription and apoptosis by mediating TGFB/BMP, IL-1, and stress signaling. Isoforms A, C, and D lack 1-2 coding segments compared to B. C and D frameshifts yield shorter C-termini (may affect TAB2 interaction). Human and mouse TAK1 are 99% identical. The TAK1 N-terminus interacts with TAB1 and contains ATP-binding and kinase domains. With TAB1 and TAB2, TRIKA2-mediated (TRAF6/TRIKA1) ubiquitinated TAK1 phosphorylates IKKB, MAP2K3, MAP2K4, and MAP2K6, which stimulate JNK1 and SAPK2. TAK1 induces NIK-independent IKBA and IKBB degradation and NFKB p50/p65 nuclear translocation. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26489	TAK1-Binding_Protein-1	Mitogen-Activated_Protein_Kinase|Signaling_Protein	TAK1-Binding Protein 1|MAP3K7IP1|Mitogen-Activated Protein Kinase Kinase Kinase 7 Interacting Protein 1|TAB1 Protein|Transforming Growth Factor Beta-Activated Kinase-Binding Protein 1	Encoded by MAP3K7IP1 Gene, ubiquitous 504-amino acid 54.6-kD TAK1-Binding Protein 1 is a MAP3K responsible for mediation of TGF-beta receptor signals and activation of TAK1 kinase. The 68 C-terminal amino acids are sufficient for binding and activation of TAK1 kinase activity. The N-terminal 418 amino acids inhibit TGFB-induced gene expression. TAB1 contains a PP2C domain and amino acids 373-418 are required for phosphorylation of p38-alpha. Formation of TRAF6/TAB1/p38-alpha complexes are enhanced by lipopolysaccharide. TAB1 also interacts with BIRC7. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26490	HGK_Protein	Mitogen-Activated_Protein_Kinase|Signaling_Protein	HGK Protein|HPK/GCK-Like Kinase|HPK/GCK-Like Kinase HGK|Hematopoietic Progenitor Kinase/Germinal Center Kinase-Like Kinase|MAP4K4|MAPK/ERK Kinase Kinase Kinase 4|MEK Kinase Kinase 4|MEKKK4|Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4|NCK Interacting Kinase	Encoded by MAP4K4 Gene (SER/THR Family, STE20 Subfamily), ubiquitous HGK Protein contains a CNH domain and an N-terminal catalytic domain with 11 kinase subdomains; it shares 47-48% amino acid identity with HPK1 and GCK catalytic domains. Of 5 tissue alternative isoforms, variant 2 is longest and contains proline-rich domains. Variants 1 and 3 lack two coding segments and variant 1 contains an extra coding segment. In response to environmental stress and cytokines such as TNFA, HGK appears to act through MAP3K7, MAP2K4, and MAP2K7 cascades to activate JNK and the c-JUN N-terminal transcriptional pathway. HGK may interact with the SH3 domain of NCK adapter proteins. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26491	RECQL_Gene	Helicase_Gene	RECQL Gene|RECQL|RECQL1|RecQ Protein-Like (DNA Helicase Q1-Like) Gene|RecQ1	The protein encoded by this gene is a member of the RecQ DNA helicase family. DNA helicases are enzymes involved in various types of DNA repair, including mismatch repair, nucleotide excision repair and direct repair. Some members of this family are associated with genetic disorders with predisposition to malignancy and chromosomal instability. The biological function of this helicase has not yet been determined. (from LocusLink)
C26492	RECQL4_Gene	Helicase_Gene	RECQL4 Gene|RECQ4|RECQL4|RTS|RecQ Protein-Like 4 Gene	This gene encodes a ATP-dependent DNA helicase. The 13.3 kD RecQL4 protein belongs to the RecQ subfamily of helicases and contains an helicase domain with a potential ATP binding site, and the DEAH box. The RecQ4 gene is predominantly expressed in thymus and testis and at low levels in other organs such as heart, brain, placenta, pancreas, small intestine, and colon, indicating that the expression of RecQ4 gene is somewhat tissue-specific. The expression of RecQ4 gene is partially upregulated in the G1/S phase of cell cycle. RecQL4 functionally suppresses promiscuous genetic recombination and ensures accurate chromosome segregation. (Beghini A. RECQL4. Atlas Genet Cytogenet Oncol Haematol. October 2001.
C26493	RECQL5_Gene	Helicase_Gene	RECQL5 Gene|RECQ5|RECQL5|RecQ Protein-Like 5 Gene	The gene was cloned by sequence similarity to known RecQ helicase genes. Northern blot analysis detected RECQL5 expression in almost all tissues tested, with notably strong expression in pancreas and testis.
C26494	_17q25_2-q25_3	Chromosome_Band	17q25.2-q25.3	A chromosome band present on 17q
C26495	HDAC1_Gene	Hydrolase_Gene	HDAC1 Gene|HD1|HDAC1|Histone Deacetylase 1 Gene|RPD3|RPD3L1	Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. (LocusLink)
C26496	HDAC2_Gene	Hydrolase_Gene	HDAC2 Gene|HDAC2|RPD3|YAF1	Histone deacetylase 2 (HDAC2), or transcriptional regulator homolog RPD3 L1, is highly homologous to the yeast transcription factor RPD3 (reduced potassium dependency 3) gene. As in yeast, human HDA2 is likely to be involved in regulating chromatin structure during transcription. It has been implicated to associate with YY1, a mammalian zinc-finger transcription factor, which negatively regulates transcription by tethering RPD3 to DNA as a cofactor. (LocusLink)
C26497	HDAC3_Gene	Hydrolase_Gene	HDAC3 Gene|HD3|HDAC3|Histone Deacetylase 3 Gene|RPD3|RPD3-2	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. (LocusLink)
C26498	HDAC4_Gene	Hydrolase_Gene	HDAC4 Gene|HA6116|HD4|HDAC-A|HDAC4|HDACA|Histone Deacetylase 4 Gene|KIAA0288	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. (LocusLink)
C26499	_2q37_2	Chromosome_Band	2q37.2	A chromosome band present on 2q
C26500	HDAC6_Gene	Hydrolase_Gene	HDAC6 Gene|HD6|HDAC6|Histone Deacetylase 6 Gene|JM21|KIAA0901	Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. (LocusLink)
C26501	CYP19A1_Gene	Cytochrome_P450_Family_Gene	CYP19A1 Gene|ARO|ARO1|CPV1|CYAR|CYP19|CYP19A1|Cytochrome P450, Family 19, Subfamily A, Polypeptide 1 Gene|P-450AROM	Human CYP19A1 gene (cytochrome P450 family 19, subfamily A), located at 15q21.1, encodes cytochrome P450 19A1, a monooxygenase enzyme with aromatase activity. Certain alleles of this gene exhibit functional mutations that result in enhanced aromatase activity which, in turn, causes familial gynecomastia.
C26502	_15q21_1	Chromosome_Band	15q21.1	A chromosome band present on 15q
C26503	Deacetylase	Hydrolase	Deacetylase	An enzyme that hydrolyzes N-acetyl groups.
C26504	SPAM1_Gene	Cell_Adhesion_Molecule_Gene	SPAM1 Gene|HYA1|HYAL1|HYAL3|MGC26532|PH-20|PH20|SPAG15|SPAM1|Sperm Adhesion Molecule 1 (PH-20 Hyaluronidase, Zona Pellucida Binding) Gene	This gene encodes a GPI-anchored enzyme located on the human sperm surface and inner acrosomal membrane. This multifunctional protein is a hyaluronidase that enables sperm to penetrate through the hyaluronic acid-rich cumulus cell layer surrounding the oocyte, a receptor that plays a role in hyaluronic acid induced cell signaling, and a receptor that is involved in sperm-zona pellucida adhesion. Abnormal expression of this gene in tumors has implicated this protein in degradation of basement membranes leading to tumor invasion and metastasis. (from LocusLink)
C26505	_7q31_3	Chromosome_Band	7q31.3	A chromosome band present on 7q
C26506	EPHX1_Gene	Hydrolase_Gene	EPHX1 Gene|EPHX|EPHX1|EPOX|Epoxide Hydrolase 1, Microsomal (Xenobiotic) Gene|MEH	This gene encodes microsomal epoxide hydrolase, a carcinogen-activating enzyme. The gene product plays an important role in both the activation and detoxification of exogenous chemicals such as polycyclic aromatic hydrocarbons. (LocusLink)
C26507	ACPP_Gene	Hydrolase_Gene	ACPP Gene|ACPP|Acid Phosphatase, Prostate Gene|PAP	Including 7 Alu repeats, the 51-kb 10-exon human ACPP Gene (HAP Family) encodes 386-aa 45-kD homodimeric prostatic acid phosphatase, which is synthesized under androgen regulation and secreted by the epithelial cells of the prostrate gland. Sequence comparison has indicated the presence of several polymorphisms. ACPP undergoes alternative splicing in the 3' UTR. (NCI)
C26508	MMP9_Gene	Metalloproteinase_Gene	MMP9 Gene|CLG4B|GELB|MMP9|Matrix Metalloproteinase 9 (Gelatinase B, 92kDa Gelatinase, 92kDa type IV Collagenase) Gene	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. (LocusLink)
C26509	_20q11_2-q13_1	Chromosome_Band	20q11.2-q13.1	A chromosome band present on 20q
C26510	MMP3_Gene	Metalloproteinase_Gene	MMP3 Gene|MMP3|Matrix Metalloproteinase 3 (Stromelysin 1, Progelatinase) Gene|SL-1|STMY|STMY1|STR1|TRANSIN	This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. (from LocusLink)
C26511	Cytochrome_P450_Family_Gene	Oxidoreductase_Gene	Cytochrome P450 Family Gene	Cytochrome P450 Family Genes encode Cytochrome P450 isozymes, hemoprotein components of the mixed-function oxidase system involving electron and/or hydrogen transport through reversible valency change of the heme iron and metabolic biotransformation of substances, including foreign compounds to mutagens and carcinogens. (NCI)
C26512	CYP2C19_Gene	Cytochrome_P450_Family_Gene	CYP2C19 Gene|CPCJ|CYP2C|CYP2C19|Cytochrome P450, Family 2, Subfamily C, Polypeptide 19 Gene|P450C2C|P450IIC19	Human CYP2C19 gene (cytochrome P450 family 2, subfamily C), located at 10q24.1-q24.3, encodes the cytochrome P450 2C19 protein, a monooxygenase enzyme that catalyzes the metabolism of drugs and xenobiotics. Several alleles of this gene contribute to the poor metabolizer phenotype, which is characterized by the inability to use cytochrome P450-dependent metabolic pathways for drug elimination.
C26513	CYP2C18_Gene	Cytochrome_P450_Family_Gene	CYP2C18 Gene|CPCI|CYP2C|CYP2C17|CYP2C18|Cytochrome P450, Family 2, Subfamily C, Polypeptide 18 Gene|P450-6B/29C|P450IIC17	Human CYP2C18 gene (cytochrome P450 family 2, subfamily C), located at 10q24, encodes cytochrome P450 2C18, a monooxygenase enzyme that catalyzes the oxidation of fatty acids, drugs and xenobiotics. This gene produces three distinct mRNA transcripts that result from exon skipping.
C26514	MMP2_Gene	Metalloproteinase_Gene	MMP2 Gene|CLG4|CLG4A|MMP2|Matrix Metalloproteinase 2 (Gelatinase A, 72kDa Gelatinase, 72kDa type IV Collagenase) Gene|TBE-1	Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling,as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. (LocusLink)
C26515	_16q13-q21	Chromosome_Band	16q13-q21	A chromosome band present on 16q
C26516	_10q24_1-q24_3	Chromosome_Band	10q24.1-q24.3	A chromosome band present on 10q
C26517	CYP2D6_Gene	Cytochrome_P450_Family_Gene	CYP2D6 Gene|CPD6|CYP2D|CYP2D6|CYP2DL1|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6 Gene|P450-DB1|P450C2D	Human CYP2D6 (cytochrome P450 family 2, subfamily D), located at 22q13.1, encodes cytochrome P450 2D6 protein, a monooxygenase enzyme that catalyzes the metabolism of drugs and xenbiotics. CYP2D6 is highly polymorphic in the human population. Many alleles of this gene contribute to the poor metabolizer phenotype, which is characterized by the inability to use cytochrome P450-dependent metabolic pathways for drug elimination. Conversely, two alleles of this gene contribute to the rapid metabolizer phenotype. Individuals who are poor metabolizers of cytochrome P450 2D6 substrates are at increased risk for the development of pesticide-induced somatic Parkinson's disease.
C26519	CYP1A2_Gene	Cytochrome_P450_Family_Gene	CYP1A2 Gene|CP12|CYP1A2|Cytochrome P450, Family 1, Subfamily A, Polypeptide 2 Gene|P3-450|P450(PA)	Human CYP1A2 gene (cytochrome P450 family 1, subfamily A), located at 15q22-qter, encodes the cytochrome P450 1A2 protein, a monooxygenase enzyme that catalyzes the metabolism of drugs and xenobiotics. Certain alleles of this gene contribute to the poor metabolizer phenotype, which is characterized by the inability to use cytochrome P450-dependent metabolic pathways for drug elimination. Functional polymorphisms in the CYP1A2 gene may increase the risk of pancreatic cancer in smokers.
C26521	_15q22-qter	Chromosome_Band	15q22-qter	A chromosome band present on 15q
C26526	_16q24_1-q24_2	Chromosome_Band	16q24.1-q24.2	A chromosome band present on 16q
C26527	HSD17B2_Gene	Oxidoreductase_Gene	HSD17B2 Gene|EDH17B2|HSD17|HSD17B2|Hydroxysteroid (17-beta) Dehydrogenase 2 Gene	Expressed in many peripheral tissues (high in placenta), human HSD17B2 Gene (SDR Family) at 16q24.1-q24.2 encodes 387-aa 43-kDa Hydroxysteroid 17-Beta Dehydrogenase 2, a potential type II membrane protein enzyme with an N-terminal type II signal-anchor motif and a C-terminal ER retention motif, likely associated with ER membranes, that uses NADH in the oxidative inactivation metabolism of testosterone and androstenedione, as well as estradiol and estrone. HSD17B2 also has 3-beta-HSD activity and 20-alpha-HSD activity toward 20-alpha-dihydroprogesterone. (NCI)
C26528	_16q2	Chromosome_Band	16q2	A chromosome band present on 16q
C26529	G6PD_Gene	Oxidoreductase_Gene	G6PD Gene|G6PD|G6PD1|Glucose-6-Phosphate Dehydrogenase Gene	Human housekeeping G6PD Gene (G6PD Family) at Xq28 encodes 2 alternative isoforms of 514-/560-aa 59-kDa homodimeric or homotetrameric cytosolic Glucose-6-Phosphate Dehydrogenase, which mainly produces NADPH, an electron donor to oxidizing agents and in biosynthetic reactions. G6PD deficiency may cause jaundice, hemolysis, or non-spherocytic hemolytic anemia. (NCI)
C26530	TPO_Gene	Oxidoreductase_Gene	TPO Gene|MSA|TPO|TPX|Thyroid Peroxidase Gene	Human TPO Gene (XPO Family) encodes multiple (at least 8) alternative isoforms of glycosylated type I membrane-bound heme glycoprotein Thyroid Peroxidase, containing an EGF-like domain and cleaved in its N-terminal part. Important for TPO delivery to the cell surface, heme is covalently bound through an H(2)O(2)-dependent autocatalytic process. TPO catalyzes iodination of thyroglobulin tyrosines and phenoxy-ester coupling of the hormonogenic tyrosines to generate thyroid hormones, thyroxine (T3) and triiodothyronine (T4). TPO mutations are associated with disorders of thyroid hormonogenesis: hypothyroidism, Graves' disease, TIOD. (NCI)
C26531	_2p25	Chromosome_Band	2p25	A chromosome band present on 2p
C26532	Mouse_Protein	Non-Human_Protein	Mouse Protein	Proteins found in any species or strain of mouse.
C26533	Xenobiotic_Metabolism	Detoxification	Xenobiotic Metabolism	The chemical reactions and physical changes involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e. g. a xenobiotic chemical, such as a pesticide. (Gene Ontology)
C26534	Rat_Protein	Non-Human_Protein	Rat Protein	Proteins found in any species or strain of rat.
C26535	ZAP-70_Gene	Receptor_Tyrosine_Kinase_Gene	ZAP70 Gene|SRK|STD|ZAP-70|ZAP-70 Gene|ZAP70|Zeta-Chain (TCR) Associated Protein Kinase 70kDa Gene	Expressed in T- and NK cells, human ZAP-70 Gene (SYK/ZAP70 Family) encodes 619-aa 70-kDa Zeta-Chain Associated Protein (tyrosine) Kinase, containing 2 SH2 domains that bind to tyrosine phosphorylated ITAM of the TCR zeta chain upon TCR stimulation, which mediates transduction of stimuli to cellular effectors in lymphocyte activation. Associated with the zeta chain, ZAP70 undergoes tyrosine phosphorylation following TCR stimulation; Tyr-319 phosphorylation is essential for full activity. Following TCR ligation, a CRKL/WIP/WASP complex is recruited by ZAP70 to lipid rafts and immunologic synapses. Phosphorylated ZAP70 interacts with CBL, SLA, and SLA2; the association probably leads to its destruction. ZAP70 defects cause Selective T-Cell Defect. (NCI)
C26536	SYK_Gene	Receptor_Tyrosine_Kinase_Gene	SYK Gene|KSYK|SYK|Spleen Tyrosine Kinase Gene	Human SYK Gene (SYK/ZAP-70 Family) at 1q12-q23 encodes alternative (635-aa, 72-kDa and 612-aa) isoforms of autophosphorylated cytosolic Spleen Tyrosine Kinase, a positive effector of BCR-stimulation, containing 2 SH2 domains, and related to ZAP-70 (T cell activation). BCR associated SYK is tyrosine phosphorylated and activated by B cell stimulation. SYK couples BCR to Ca2+ mobilization through a PI3K pathway when (linker region) not Tyr phosphorylated or through a PLC-G pathway, when Tyr phosphorylated. SYK phosphorylation enhances PLC-gamma phosphorylation. Differential SYK phosphorylation can regulate BCR-coupled calcium pathways. Phosphorylated SYK interacts with CBL and SLA; SLA interaction may link it to CBL, a negative adapter protein regulator of BCR-calcium signaling. SYK Tyr phosphorylation creates a c-CBL binding site.  (NCI)
C26537	DHODH_Gene	Oxidoreductase_Gene	DHODH Gene|DHODH|Dihydroorotate Dehydrogenase Gene	The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis.  It is a drug target in the pyrimidine biosynthetic pathway.  Variation in gene expression or sequence may alter the efficacy of chemotherapy. (from LocusLink and NCI)
C26538	DHFR_Gene	Oxidoreductase_Gene	DHFR Gene|DHFR|Dihydrofolate Reductase Gene	This gene encodes dihydrofolate reductase that converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids.  It is a drug target.  Variation in gene expression or sequence may alter the efficacy of chemotherapy. (from LocusLink and NCI)
C26539	BLK_Gene	SRC_Family_Gene	BLK Gene|B Lymphoid Tyrosine Kinase Gene|BLK|MGC10442	Human BLK Gene (SRC Family) encodes (p55) B Lymphoid Tyrosine Kinase, a non-receptor protein tyrosine kinase in B-lymphoid cells activated within seconds after crosslinking the mIg complex that likely functions in a signal transduction pathway specific to this lineage. Expression of BLK in immature T-cells suggests that it may also play a role in thymopoiesis. The protein has SH3, SH2, and catalytic domains that contain SRC tyrosine kinase family consensus sequences. (NCI)
C26540	_5q11_2-q13_2	Chromosome_Band	5q11.2-q13.2	A chromosome band present on 5q
C26541	_8p23-p22	Chromosome_Band	8p23-p22	A chromosome band present on 8p
C26542	DPYD_Gene	Oxidoreductase_Gene	DPYD Gene|DHP|DPD|DPYD|Dihydropyrimidine Dehydrogenase Gene	Encodes dihydropyrimidine dehydrogenase, an enzyme involved in pyrimidine catabolism. Increased DPD levels can influence tumor response to 5-fluorouracil-based chemotherapy through increased inactivation of the agent in tumor cells. Increases of the DPD mRNA level in cancerous tissue seem to reflect tumor progression. High DPD mRNA levels in liver metastasis and advanced colorectal cancer may have clinical importance for 5-fluorouracil-based chemosensitivity. (from Ann Surg Oncol 2002;9:599-603)
C26544	ADAM15_Gene	ADAM_Family_Gene	ADAM15 Gene|A Disintegrin and Metalloproteinase Domain 15 Gene|ADAM15|MDC15	This gene encodes disintegrin and metalloprotease (ADAM) domain 15, which is a member of the ADAM protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein member contains an RGD tripeptide in its disintegrin domain, and the specific interaction of the recombinant ADAM15 with integrin alpha5beta3 is RGD-dependent, suggesting that this protein may be involved in alpha5beta3-mediated cell-cell adhesion. (LocusLink)
C26545	_1q21_3	Chromosome_Band	1q21.3	A chromosome band present on 1q
C26546	PLAT_Gene	Protease_Gene	PLAT Gene|PLAT|Plasminogen Activator, Tissue Gene|TPA	Containing STRPs and a polymorphic Alu, 32.5-kb human PLAT Gene (Peptidase S1 Family) at 8p12 encodes Tissue Plasminogen Activator 1 (562-aa, 63-kD), 2 (291-aa), and 3 (516-aa). Frameshifted variant 2 (lacks Ex9-11) has a distinct C-terminus; variant 3 lacks Ex4. EGF-like, fibronectin I, and kringle domains mediate fibrin, LRP1, annexin II, and cytokeratin 8 binding. TPA also binds to laminin, fibronectin, and mannose receptor. Inhibited by PAI-1, serine protease TPA is widely expressed as an active single chain, then secreted, and cleaved by plasmin, tissue kallikrein, or factor XA to a fully active disulfide linked A/B-protein; N-heavy chain and C-light chain. Important in cell migration and tissue remodeling, TPA activates (increased by fibrin or heparin) plasminogen to fibrinolytic plasmin conversion by hydrolyzing a specific Arg-Val bond. Altered activity causes hyper- or hypofibrinolysis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26547	_8p12	Chromosome_Band	8p12	A chromosome band present on 8p
C26548	Gene_Product	root_node	Gene Product|Genome Encoded Entity	A molecule whose structure is represented in and determined by genomic sequences; includes Proteins, Functional RNAs, Protein Complexes, and Riboprotein Complexes.
C26549	Functional_RNA	Gene_Product	Functional RNA|Non-Coding|Non-Coding RNA	The product of so-called RNA genes; a functional RNA represents the final product of a gene rather than a transient molecule that will be translated into protein.
C26550	NRG3_Gene	Growth_Factor_Gene	NRG3 Gene|NRG-3|NRG3|Neuregulin 3 Gene|pro-NRG3	Expressed in brain (4.4-kb transcript) and testis (1.9-kb transcript), human NRG3 Gene (NRG Family) at 10q22 encodes conserved 720-aa Neuregulin 3, a soluble growth and differentiation factor and a type I membrane protein containing 2 hydrophobic segments similar to the transmembrane domain and internal signal sequence in NRG1. NRG3 also contains an N-Ala/Gly-rich segment, an EGF motif, and a mucin-like Ser/Thr-rich region with sites for O-linked glycosylation. Membrane-bound NRG3 may be inactive. Preceded by extensive glycosylation, external proteolytic cleavage close to the plasma membrane may involve dimerization of the intracellular domain. A ligand for ERBB4 receptor tyrosine kinase (likely via the EGF-like domain), NRG3 does not bind to ERBB2, ERBB3, or EGF receptor. The ERBB4 binding sites of NRG1 and NRG3 may overlap. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26552	Caspase_Gene	Protease_Gene	Caspase Gene	These genes encode caspases, a family of intracellular cysteine proteinases involved in inflammation and apoptosis. These enzymes appear to be involved in the initial signaling events, as well as the downstream proteolytic cleavages, that result in apoptotic cell death. They are specific for aspartic acid at the P1 position and are divided into two classes based on the lengths of their N-terminal pro-domains. Caspases-1, -2, -4, -5, -8, and -10 have long pro-domains while caspases-3, -6, -7, and -9 have short pro-domains. (from Science 1998. 281:1312 and Br Med Bull 1997. 53:478)
C26554	CASP1_Gene	Caspase_Gene	CASP1 Gene|CASP-1|CASP1|Caspase 1, Apoptosis-Related Cysteine Protease Gene|Caspase-1 Gene|ICE|IL-1 Beta Converting Enzyme Gene|IL-1BC|IL1B-Convertase Gene|IL1BC|IL1BCE|Interleukin 1-B Converting Enzyme Gene|Interleukin 1-Beta Convertase Gene|Interleukin-1 Beta Converting Enzyme Gene|P45 Gene	The CASP1 gene at 11q23 encodes Caspase-1, a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of the similar gene in mouse suggested its role in the pathogenesis of Huntington disease. Alternative splicing of this gene results in five transcript variants encoding distinct isoforms. (From LocusLink)
C26555	Generation_of_Antibody_Diversity	Immunoglobulin_Gene_Rearrangement	Generation of Antibody Diversity	Generation of Antibody Diversity during B-lymphocyte development results from a cascade of temporally ordered random gene shuffling translocations by a recombinase that join any one of multiple alternative discrete V, D, and J (heavy chain) or V and J (light chain) antibody gene variable region DNA coding segments that produce in each B-lymphocyte an antibody with a unique antigen binding region composed of a heavy and a light protein chain. In addition, splicing inaccuracies or insertion of additional nucleotides at the segment junctions generate further junctional diversity and somatic hypermutation of V regions, as B-lymphocytes proliferate, create better fitting antigen-binding sites.
C26556	DNTT_Gene	Polymerase_Gene	DNTT Gene|DNTT|Deoxynucleotidyltransferase, Terminal Gene|TDT	Human DNTT Gene encodes Terminal deoxynucleotidyltransferase, a unique DNA polymerase that without template direction catalyzes the addition of deoxyribonucleotides onto the 3-prime-hydroxyl end of DNA primers. TDT catalyzes the insertion of nucleotides (N regions) at the V(H)-D and D-J(H) junctions of immunoglobulin genes. The enzyme is present in immature thymocytes, some bone marrow cells, transformed pre-B and pre-T cell lines, and leukemia cells.
C26557	_10q23-q24	Chromosome_Band	10q23-q24	A chromosome band present on 10q
C26558	PRIM1_Gene	Protein_Complex_Subunit_Gene	PRIM1 Gene|PRIM1|Primase, Polypeptide 1, 49kDa Gene	Human PRIM1 Gene (Eukaryotic Primase Small Subunit Family) encodes 420-aa 49-kDa Primase Polypeptide 1, the small subunit of heterodimeric DNA Primase. Eukaryotic DNA replication involves a chromosomal replication apparatus containing key enzymatic components DNA Primase and DNA Polymerase Alpha. DNA Primase is a polymerase that synthesizes small RNA primers for Okazaki fragments made during discontinuous DNA replication. Zinc bound to a PRIM1 zinc knuckle motif appears be involved in sequence recognition and binding of ssDNA. (NCI)
C26559	PRIM2B_Gene	Retired_Concepts	PRIM2B Gene|PRIM2|PRIM2B	The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus.  Two of the enzymes that are part of this machinery are DNA polymerase alpha (POLA), the principal replication enzyme, and primase, the enzyme that catalyzes the synthesis of oligoribonucleotide primers on a DNA template; the primers are required by DNA polymerase alpha to initiate DNA synthesis.  These 2 proteins form an enzymatic complex Primase, in turn, is a complex of two proteins, a 49kDa subunit and a 58kDa subunit.  This gene encodes the 58kDa subunit.  (from OMIM)
C26560	_6p12-p11_1	Chromosome_Band	6p12-p11.1	A chromosome band present on 6p
C26561	Primase_Polypeptide-2B	Retired_Concepts	Primase Polypeptide 2B|PRIM2B|Primase, p58 Subunit	The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus.  Two of the enzymes that are part of this machinery are DNA polymerase alpha (POLA), the principal replication enzyme, and primase, the enzyme that catalyzes the synthesis of oligoribonucleotide primers on a DNA template; the primers are required by DNA polymerase alpha to initiate DNA synthesis.  These 2 proteins form an enzymatic complex Primase, in turn, is a complex of two proteins, a 49kDa subunit and a 58kDa subunit.  Mutation of the 58kDa subunit suggests that it is important for initiation, elongation, and counting.  (from OMIM and Biochemistry 2002;41:4891-900)
C26562	Primase_Polypeptide-1	Protein_Complex_Subunit	Primase Polypeptide 1|DNA Primase 1|DNA Primase 49kDa Subunit|DNA Primase Small Subunit|DNA Primase Subunit 48|PRIM1|Primase p49 Subunit|Primase, p49 Subunit	Encoded by human PRIM1 Gene (Eukaryotic Primase Small Subunit Family), 420-aa 49-kDa Primase Polypeptide 1 is the small subunit of heterodimeric DNA Primase. Eukaryotic DNA replication involves a chromosomal replication apparatus containing key enzymatic components DNA Primase and DNA Polymerase Alpha. DNA Primase is a polymerase that synthesizes small RNA primers for Okazaki fragments made during discontinuous DNA replication. Zinc bound to a PRIM1 zinc knuckle motif appears be involved in sequence recognition and binding of ssDNA. (NCI)
C26563	Ethylnitrosourea	Carcinogenic_Nitrosourea|Mutagen|Nitrosourea_Compound	Ethylnitrosourea|1-Ethyl-1-nitrosourea|ENU|N-Ethyl-N-nitrosourea|N-Nitroso-N-Ethylurea|Nitrosoethylurea	A nitrosourea with potential antineoplastic activity.  Used experimentally as a mutagen and carcinogen, ethylnitrosourea alkylates DNA and proteins, thereby damaging DNA and inducing point mutations. (NCI04)
C26564	FASN_Gene	Transferase_Gene	FASN Gene|FAS|FASN|Fatty Acid Synthase Gene|MGC14367|MGC15706|OA-519	This gene encodes, fatty acid synthase (FAS), a key metabolic enzyme catalyzing the synthesis of long-chain saturated fatty acids. It plays a central role in the production of surfactant in fetal lungs, in the supply of fatty components of milk, and in the conversion and storage of energy in liver and adipose tissue. Remarkably high levels of FAS expression are found in the majority of human epithelial cancers.  Experimental manipulation suggests a link between FAS overexpression and dysregulation of membrane composition and functioning in tumor cells. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. (from Biochem Biophys Res Commun 2003;302:898-903 and LocusLink)
C26565	Fatty_Acid_Metabolism	Lipid_Metabolism	Fatty Acid Metabolism	Fatty Acid Metabolism involves cellular biotransforming chemical modifications of fatty acids, straight chain monocarboxylic acids, by enzymatic activity.
C26566	CASP2_Gene	Caspase_Gene	CASP2 Gene|CASP-2|CASP2|Caspase 2, Apoptosis-Related Cysteine Protease Gene|Caspase-2 Gene|ICH-1 Protease Gene|ICH-1L|ICH-1L/1S|ICH1|NEDD2|NEDD2 Apoptosis Regulatory Gene	The CASP2 gene at 7q34-q35 encodes Caspase-2, a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspase-2 is synthesized as an inactive proenzyme which is activated by an alternative CD 95 pathway which involves the formation of a complex between oligomerized CD 95 and the accessory proteins RIP and RAIDD. After activation, caspase 2 induces apoptosis by triggering the caspase cascade. The proteolytic cleavage of this caspase is induced by a variety of apoptotic stimuli. In contrast to caspase 8, caspase 2 contains no death effector domain. (From LocusLink and NCI)
C26567	NMT2_Gene	Transferase_Gene	NMT2 Gene|N-Myristoyltransferase 2 Gene|NMT2	NMT2 encodes N-myristoyltransferase 2 and its expression was direct responses to carcinogen exposure. Because inappropriate protein NH(2)-terminal myristoylation appears to play a role in carcinogenesis, induction of NMT2 may play a central role in dioxin carcinogenicity. (from Cancer Res 2001;61:8534-9)
C26568	CREBBP_Gene	Transcription_Factor_Gene	CREBBP Gene|CBP|CREB Binding Protein (Rubinstein-Taybi Syndrome) Gene|CREBBP|RSTS|RTS	CREB-binding protein, a 265 kD member of a family of transcription factor co-activators now referred to as p300/CBP.  Originally identified as a nuclear protein bound by the Protein Kinase A-phosphorylated form of CREB (cAMP responsive element binding protein).
C26569	EP300_Gene	Transcription_Coactivator_Gene	EP300 Gene|E1A Binding Protein p300 Gene|EP300|p300	EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CREB-binding protein (CBP), and like CPB can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF. (from LocusLink)
C26571	HAT1_Gene	Transferase_Gene	HAT1 Gene|HAT1|Histone Acetyltransferase 1 Gene	This gene encodes histone acetyltransferase 1. The HAT1 holoenzyme consists of 2 subunits: the catalytic 46-kD HAT1 and the accessory p46 (RBBP7). The p46 subunit stimulated the activity of HAT1 and bound to core histones. The HAT1 holoenzyme acetylated newly synthesized but not nucleosomal histone H4 at lys5 and lys12, and, to a lesser extent, histone H2A at lys5. HAT1 and p46 polypeptides are located in the nucleus of S-phase cells. (from LocusLink)
C26572	_2q31_2-q33_1	Chromosome_Band	2q31.2-q33.1	A chromosome band present on 2q
C26573	PCAF_Gene	Ligand_Binding_Protein_Gene	PCAF Gene|CAF|P/CAF|PCAF|p300/CBP-Associated Factor Gene	CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation. The PCAF gene encodes p300/CBP-Associated Factor, which displays in vivo binding activity with CBP and p300. This protein has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that it plays a direct role in transcriptional regulation. It also associates with NF-kappa-B p65. Protein kinase A regulates the transcriptional activity of NF-kappa-B by modulating its interaction with CPB/p300. (from LocusLink)
C26574	CASP3_Gene	Caspase_Gene	CASP3 Gene|Cysteine Protease CPP32 Gene|PARP Cleavage Protease Gene|SCA-1 Gene|SREBP Cleavage Activity 1 Gene	The CASP3 gene at 4q34 encodes Caspase-3, a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Caspase-3 is a central player in mediating apoptosis and is the most widely studied caspase. This protein cleaves and activates caspases 6, 7 and 9, and itself can be processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants which encode the same protein. (From LocusLink and NCI)
C26575	HTATIP_Gene	Transferase_Gene	HTATIP Gene|HIV-1 Tat Interacting Protein, 60kDa Gene|HTATIP|HTATIP1|PLIP|TIP60|cPLA2	HTATIP was originally isolated as an HIV-1 TAT-interactive protein. It encodes TIP60 protein which is a histone acetylase and plays a role in DNA repair and apoptosis. (LocusLink)
C26576	_4q34	Chromosome_Band	4q34	A chromosome band present on 4q
C26577	_11q12_1	Chromosome_Band	11q12.1	A chromosome band present on 11q
C26578	FGF9_Gene	Fibroblast_Growth_Factor_Gene_Family	FGF9 Gene|FGF9|Fibroblast Growth Factor 9 (Glia-Activating Factor) Gene|GAF|HBFG-9	Expressed by glia and neurons, human FGF9 Gene (FGF family) encodes 208-aa 23-kDa (precursor) N-glycosylated monomeric secreted Fibroblast Growth Factor 9, with glial growth-stimulating effects and likely involved in glial cell growth and differentiation, gliosis, and differentiation or survival of neuronal cells. Three molecular species of 30-kDa, 29-kDa and 25-kDa, cleaved at Leu-4, Val-13 and Ser-34 respectively, are found. Expression may be dependent on Sonic hedgehog signaling. (NCI)
C26581	PLAU_Gene	Protease_Gene	PLAU Gene|PLAU|Plasminogen Activator, Urokinase|UPA|URK	One of three genes nested in PCDH15 introns, 8-kb human PLAU Gene (Peptidase S1 Family) at 10q24 encodes a 431-aa 48.5-kD single-chain Urokinase precursor containing a kringle and EGF-like domain. A potent activator of plasminogen to plasmin conversion by Arg-Val cleavage, the two-chain serine protease is composed of disulfide-linked A (18,000 D) and B (33,000 D) chains that arise from precursor Lys(158)-Ile(159) cleavage by plasmin. Urokinase occurs in high and low mass forms, each consisting of A and B chains. The high mass form contains a long A chain; cleavage after residue 155 in the low mass form yields a short A1 chain. Urokinase is immunologically unrelated to TPA. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26582	FAP_Gene	Protease_Gene	FAP Gene|FAP|FAPA|Fibroblast Activation Protein, Alpha Gene	Expressed primarily in fibroblasts, 73-kb human FAP Gene (Peptidase S9B Family) at 2q23 (near DPP4) encodes inducible Fibroblast Activation Protein, Alpha major isoform 1 (Long, 760-aa, 87.8-kD) and truncated isoform 2 (Short, 239-aa). FAPA is similar to DPP4 and DPPX. Heterodimeric (with DPP4) or homodimeric, N-glycosylated FAPA is a type II integral membrane protein gelatinase: 13 extracellular cysteine residues and 3 conserved serine protease domains, a transmembrane segment, and a short cytoplasmic tail. Monomer is inactive. On lamellipodia, FAPA appears involved in epithelial-mesenchymal interactions during development, tissue repair/remodeling, epithelial carcinogenesis, and malignant invasion. A product of the same gene, monomeric N-glycosylated Seprase is composed of proteolytically inactive subunits whose activities depend on subunit association. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26583	_2q23	Chromosome_Band	2q23	A chromosome band present on 2q
C26584	KLK2_Gene	Protease_Gene	KLK2 Gene|KLK2|Kallikrein 2, Prostatic Gene	One of several kallikrein genes, 7-kb human KLK2 Gene (Kallikrein Family) at 19q13.41 encodes alternative Prostatic Kallikrein 2 isoforms: 1 (261-aa, 28.7-kD prepropeptide), 2 (PGK-10A, 222-aa), 3 (164-aa). The mature serine protease is 237 amino acids. About 12-kb apart, KLK2 and APS are aligned head-to-tail. The glandular kallikrein family may comprise 25-30 genes that encode specific proteases involved in processing of active peptides. KLK2 exhibits 66% and 73% homology with KLK1 and APS. Glandular kallikreins release vasoactive peptides from kininogen; the kininogenase activity of different kallikreins is highly variable. Kallikrein 2 cleaves kininogen Met-X, Arg-X, or Leu-X bonds to release lys-bradykinin (kallidin) involved in vasodilation and smooth muscle contraction. The physiologic role of specific kallikreins is often unrelated to the kininogenase activity. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26585	KLK3_Gene	Protease_Gene	KLK3 Gene|APS|KLK3|KLKB1|Kallikrein 3, (Prostate Specific Antigen) Gene|PSA	Regulated by androgens and one of 15 clustered kallikrein genes, 5-exon 6-kb human KLK3 Gene (Kallikrein Family) at 19q13.41 generates alternate isoforms of a single-chain 261-aa 30-kD (precursor) Kallikrein 3 glycoprotein (Prostate Specific Antigen); additional variants may exist. Using an alternate coding region splice site, frameshifted isoform 2 has a shorter distinct C-terminus. AREs reside in the KLK3 proximal promoter; distal AREs and a cell-specific enhancer map upstream. A serine protease in seminal plasma, PSA may function in liquefaction of seminal coagulum by (preferential Tyr-X) cleavage of seminal vesicle protein. Kallikrein proteases have diverse functions. Mounting evidence implicates kallikreins in carcinogenesis; some have potential as cancer biomarkers. The serum level of PSA is useful in diagnosis and monitoring of prostatic carcinoma. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26586	ST14_Gene	Protease_Gene	ST14 Gene|HAI|MT-SP1|MTSP-1|MTSP1|PRSS14|SNC19|ST14|Suppression of Tumorigenicity 14 (Colon Carcinoma, Matriptase, Epithin) Gene|TADG-15|TADG15	Expressed in prostate, kidney, lung, small intestine, stomach, colon, placenta, spleen, liver, leukocytes, and thymus, 51-kb human ST14 Gene (Peptidase S1 Family) at 11q24-q25 generates a 3.3-kb transcript that encodes an 855-aa 95-kD membrane-associated serine protease, Matriptase. ST14 contains an N-region integrin-binding site, N-glycosylation sites, tandem LDLR class A cysteine repeats, CUB domains, a putative proteolytic activation site, a C-terminal trypsin-like serine protease region, an S1 pocket, an S2 subsite, and an S4 cavity. Protease specificity involves additional cleavage site residues. Complexed with 40-kD SPINT1, a Kunitz-type inhibitor, ST14 is activated by sphingosine 1-phosphate, degrades extracellular matrix, and cleaves/activates HGF and urokinase plasminogen activator. ST14 may play a role in cancer invasion and metastasis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26587	_11q24-q25	Chromosome_Band	11q24-q25	A chromosome band present on 11q
C26588	PRSS8_Gene	Protease_Gene	PRSS8 Gene|PRSS8|Protease, Serine, 8 (Prostasin) Gene	Expressed in prostate, liver, salivary gland, kidney, lung, pancreas, colon, bronchus, and kidney epithelia, 4.4-kb 6-exon single-copy human PRSS8 Gene (Peptidase S1 Family) at 16p11.2 encodes secreted or membrane anchored 343-aa 36-kD (precursor) Serine Protease-8, similar to acrosin, plasma kallikrein, hepsin, and xCAP1 (Xenopus). Five-prime regulatory elements include an AP2 site, erythroid-specific elements, a sterol regulatory element, a variant GC box, and an AP1 site; no TATA box is found. The proprotein is cleaved (aa 12-13) to produce disulfide-linked light and heavy chains. The C terminal hydrophobic region is cleaved (aa 290-291) during secretion. Likely involved in semen coagulation and liquefaction, PRSS8 is active with trypsin-like specificity on Lys or Arg carboxyl peptide linkages. Prostasin may regulate ENaC. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26589	PRTN3_Gene	Protease_Gene	PRTN3 Gene|ACPA|AGP7|MBN|MBT|PR3|PRTN3|Proteinase 3 (Serine Proteinase, Neutrophil, Wegener Granulomatosis Autoantigen) Gene	Located in a cluster and coordinately expressed with closely related ELA2 and AZU during myeloid development, 5-exon 7-kb human PRTN3 Gene (Peptidase S1 Family) at 19p13.3 responds to G-CSF; the promoter contains PU.1, C/EBP, and c-MYB sites. Packed in neutrophilic azurophil granules, the encoded 256-aa 29-kD Proteinase 3 precursor is an antibiotic neutral serine protease that appears to degrade elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV by preferential cleavage at Ala-X and Val-X bonds. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26590	GPI_Gene	Isomerase_Gene|Signaling_Pathway_Gene	GPI Gene|AMF|GNPI|GPI|Glucose Phosphate Isomerase Gene|NLK|PGI|PHI|SA-36	The single 18-exon (44-153 bp; all GT/AG splice sites) 40-kb human GPI Gene (GPI Family) at 19q13.1 encodes Glucose-6-Phosphate Isomerase, Neuroleukin, and Autocrine Motility Factor. The protein functions in different capacities. In glycolysis and gluconeogenesis, homodimeric cytoplasmic GPI catalyzes reversible G6P and F6P isomerization. Produced by lectin-stimulated T-cells, secreted non-mitogenic NLK lymphokine acts early in antibody-secreting cell formation to induce Ig secretion. Also a neurotrophic factor for spinal and sensory neurons, NLK exhibits GPI activity. AMF is a 558-amino acid 55-kD autocrine motility polypeptide. The gene product is partly homologous to a conserved region of HTLV-III-LAV external envelope protein. Gene defects cause nonspherocytic hemolytic anemia and hydrops fetalis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26591	TOP1_Gene	Isomerase_Gene|Regulatory_Gene	TOP1 Gene|TOP1|Topoisomerase (DNA) I Gene	The single-copy 95.7-kb human TOP1 Gene (TOPI Family) at 20q12-q13.1 contains 0.2-30 kb introns and 21 exons that encode 765-aa 90.7-kD monomeric DNA Topoisomerase I, which catalyzes transient ATP-independent breaking/rejoining of DNA and controls DNA topology during transcription. Mouse Top-1 exhibits a similar exon-intron structure. Two truncated pseudogenes occur in the human genome; one pseudogene exists in the mouse genome. DNA topoisomerases I and II relax negative and positive supercoils; TOP1 breaks single DNA strands, TOP2 breaks duplex DNA. Specifically inhibited by the antitumor plant alkaloid CPT, when TOP1 breaks the DNA backbone bond it forms a protein-DNA link (a tyrosyl oxygen joins to a DNA strand end phosphorus). (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26592	TOP2A_Gene	Isomerase_Gene|Regulatory_Gene	TOP2A Gene|TOP2|TOP2A|TP2A|Topoisomerase (DNA) II Alpha 170kDa Gene	Linked to ERBB2, single-copy 35-exon 30-kb human TOP2A Gene (TOPII Family) at 17q21-q22 encodes alternative homodimeric nuclear DNA Topoisomerase II, Alpha isoforms 1 (1531-aa, 174.4-kD), 2 (1557-aa), 3 (1567-aa), and 4 (1612-aa). TOPII alpha and beta appear derived from duplicate independently expressed genes. Controlling DNA topology, TOP2A catalyzes transient ATP-dependent double-strand breakage/relaxation and rejoining of negative/positive supercoiled DNA during transcription, replication, chromosome condensation, and chromatid separation. TOPII reactions likely involve crossing-over. TOP2A is associated with Pol II holoenzyme. Inhibited by intercalating amsacrine, TOP2A is a target for several anticancer agents. Mutations are linked with drug resistance and perhaps ataxia-telangiectasia. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26593	TOP2B_Gene	Isomerase_Gene|Regulatory_Gene	TOP2B Gene|TOP2B|TOPIIB|Topoisomerase (DNA) II Beta 180kDa Gene	The 36-exon 67-kb human TOP2B Gene (TOPII Family) at 3p24 encodes alternative homodimeric nuclear DNA Topoisomerase II, Beta isoforms: 2 (1626-aa, 183-kD) and 1 (1621-aa). TOPII beta and alpha appear derived from duplicate independently expressed genes. Controlling DNA topology, TOP2B catalyzes transient ATP-dependent double-strand breakage/relaxation and rejoining of negative/positive supercoiled DNA during transcription, replication, chromosome condensation, and chromatid separation. With 72% similarity in TOP2, TOP2A/B N-terminal ATPase and central breakage/reunion domains are conserved; the C-terminal domains differ markedly. The TOP2B C-terminus contains potential phosphorylation sites. TOP2B is a target for several anticancer agents. Mutations are linked with drug resistance and perhaps ataxia-telangiectasia. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26594	TOP3A_Gene	Isomerase_Gene	TOP3A Gene|TOP3|TOP3A|Topoisomerase (DNA) III Alpha Gene	Mapped between D17S447 and D17S258, 43.6-kb single-copy human TOP3 Gene (TOPI/III Family) at 17p12-17p11.2 is expressed in multiple somatic tissues (highest in testis, heart, skeletal muscle, pancreas) as long (1001-aa, 112-kD) and short (976-aa) alternative DNA Topoisomerase III Alpha isoforms that share no homology with DNA TOPI. TOP3A catalyzes transient ATP-independent breaking/rejoining of single DNA strands, reducing negative supercoils and controlling DNA topology during transcription. The enzyme forms a complex with BLM (aa 1-133 of BLM), which recruits TOP3A to PML nuclear bodies and regulates somatic sister chromatid recombination. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26595	_17p12-17p11_2	Chromosome_Band	17p12-17p11.2	A chromosome band present on 17p
C26596	PTGS1_Gene	Oxidoreductase_Gene|Signaling_Pathway_Gene	PTGS1 Gene|COX1|COX3|PCOX1|PGG/HS|PGHS-1|PGHS1|PHS1|PTGHS|PTGS1|Prostaglandin-Endoperoxide Synthase 1 (Prostaglandin G/H Synthase and Cyclooxygenase) Gene	The 20-40-kb (11 coding exons) human PTGS1 Gene (PGHS Family) at 9q32-q33.3 encodes alternative homodimeric monotopic ER membrane Prostaglandin-Endoperoxide Synthase 1 isoforms with an EGF-like domain and identical N/C-regions in a constitutive 2.8-kb mRNA: long (599-aa, 69-kD precursor) and short (562-aa). COX3 (5-kb) and PCOX1A (deleted Ex5-8, lacking COX activity) mRNAs retain a conserved intron 1 ORF, altering the signal peptide (uncleaved) in the glycosylated membrane peptides. Rate-limiting in prostaglandin and thromboxane synthesis, bifunctional PTGS1 appears involved in cell signaling, angiogenesis, and tissue homeostasis. PGH COX activity converts arachidonate to PGG2; PGH peroxidase converts PGG2 to PGH2. COX1 is inhibited by NSAIDs such as aspirin (irreversible ser529 acetylation). (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26597	_9q32-q33_3	Chromosome_Band	9q32-q33.3	A chromosome band present on 9q
C26598	PTGS2_Gene	Oxidoreductase_Gene|Signaling_Pathway_Gene	PTGS2 Gene|COX-2|COX2|PGG/HS|PGHS-2|PHS-2|PTGS2|Prostaglandin-Endoperoxide Synthase 2 (Prostaglandin G/H Synthase and Cyclooxygenase) Gene|hCOX-2	The cytokine/mitogen-induced 4.5-kb mRNA of 7.5-8.5kb 10-exon human PGHS2 Gene (PGHS Family) at 1q25.2-q25.3 encodes homodimeric microsomal membrane 604-aa 69-kD (precursor) Prostaglandin-Endoperoxide Synthase 2, with 1 EGF-like domain, involved in prostanoid-induced inflammation and mitogenesis (86-89% identity with mammalian PTGS2 proteins). LPS, PMA, IL1-Beta, hCG, LH and glucocorticoids regulate PGHS2 expression. 3-Prime UTR AU-rich repeats bind to CUGBP2 facilitating mRNA stability and translation inhibition. A target of NSAIDs, rate-limiting PGHS2 dioxygenase and peroxidase activity converts arachidonate to prostaglandins and thromboxanes. COX2 induction stimulates peripheral nociceptors. Deregulated expression may enhance carcinogenic potential; weak expression in pheochromocytomas favors benign diagnosis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C26599	_1q25_2-q25_3	Chromosome_Band	1q25.2-q25.3	A chromosome band present on 1q
C26600	PF4_Gene	CXC_Cytokine_Gene	PF4 Gene|CXCL4|PF4|Platelet Factor 4 (Chemokine (C-X-C Motif) Ligand 4) Gene|Platelet Factor 4 Gene|SCYB4	This gene encodes platelet factor-4, a 70-amino acid CXC chemokine. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair. (from OMIM)
C26603	_4q12-q21	Chromosome_Band	4q12-q21	A chromosome band present on 4q
C26606	FOSB_Protein	FOS_Family_Protein	FOSB Protein|FBJ Murine Osteosarcoma Viral Oncogene Homolog B|FOSB	Encoded by human FOSB Gene, FOSB is a leucine zipper protein that can dimerize with proteins of the JUN family, forming transcription factor complex AP-1. As such, FOSB appears to be a regulator of cell proliferation, differentiation, and transformation. (NCI)
C26607	FOSB_Gene	FOS_Family_Gene	FOSB Gene|FBJ Murine Osteosarcoma Viral Oncogene Homolog B Gene|FOSB|GOS3|GOSB	A member of the Fos gene family.  This family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. (from LocusLink)
C26608	_19q13_32	Chromosome_Band	19q13.32	A chromosome band present on 19q
C26609	ATF2_Gene	Transcription_Factor_Gene	ATF2 Gene|ATF2|Activating Transcription Factor 2 Gene|CRE-BP1|CREB2|HB16|TREB7	This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. (from LocusLink)
C26610	Pro-Platelet_Basic_Protein	Alpha_Chemokine	Pro-Platelet Basic Protein|Beta TG|Beta Thromboglobulin|Beta-TG|CXC Chemokine Ligand 7|NAP-2|Neutrophil-Activating Peptide 2|PPBP|Platelet Basic Protein|Thrombocidin 1|Thrombocidin 2|bTG	A product of the PPBP gene, pro-platelet basic protein is processed into platelet basic protein (PBP) and connective-tissue-activating peptide III (CTAP-III).  Upon platelet activation these proteins undergo further processing into beta thromboglobulin (Beta-TG) and neutrophil-activating peptide 2 (NAP2), respectively.  Many of the function ascribed to CTAP-III may actually be the result of processing to NAP-2.
C26611	PPBP_Gene	CXC_Cytokine_Gene	PPBP Gene|Beta-TG|CTAP3|CTAPIII|CXCL7|LA-PF4|LDGF|MDGF|NAP-2-L1|NAP2|PBP|PPBP|Pro-Platelet Basic Protein (Chemokine (C-X-C Motif) Ligand 7) Gene|SCYB7|TGB|TGB1|THBGB|THBGB1|b-TG1	Human PPBP Gene (Alpha Chemokine CXC Family) encodes secreted 128-aa 14-kDa (precursor) Pro-Platelet Basic Protein, a platelet-derived growth factor that is processed to PBP and CTAP-III. Proteolytic removal of PPBP residues 1-9 produces active peptide CTAP-III/LA-PF4, which stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan, as well as formation and secretion of plasminogen activator. Upon platelet activation, PBP is proteolytically converted to beta thromboglobulin, a homotetramer released when platelets aggregate; CTAP-III is proteolytically converted to NAP2, a potent chemoattractant and activator of neutrophils. (NCI)
C26612	Activin_A_Receptor_Type-I	Receptor_Serine-Threonine_Kinase	Activin A Receptor, Type I|ACVR1|Activin A Receptor, Type II-Like Kinase 2|EC 2.7.1.37|Hydroxyalkyl-Protein Kinase	Activins are dimeric growth and differentiation factors that belong to the TGF-beta superfamily of signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases that include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Encoded by human ACVR1 Gene, Activin A Receptor Type I signals a particular transcriptional response in concert with activin type II receptors. (LocusLink)
C26613	Activin-A_Receptor_Type-II-Like-1_Protein	Receptor_Serine-Threonine_Kinase	Activin A Receptor Type II-Like 1|ACVRL1|ACVRLK1|Activin A Receptor, Type II-Like Kinase|Activin Receptor-like Kinase 1|EC 2.7.1.37|Serine/threonine-protein kinase Receptor R3 Precursor|TGF-B Superfamily Receptor Type I	Activin A receptor, type II-like 1 (also called activin receptor-like kinase 1) is a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The ACVRL1 gene encodes a protein that shares similar domain structures with 3 other closely related ALK proteins (ALK2, ALK3, and ALK4) that together form a subfamily of receptor serine/threonine kinases. ACVRL1 is most highly expressed in human placenta and lung. ACVRL1 deficiency causes hemorrhagic telangiectasia type 2 (HHT2) also known as Rendu-Osler-Weber syndrome 2 (ORW2). (NCI)
C26614	Neutrophil-Activating_Peptide-2	Alpha_Chemokine	Neutrophil-Activating Peptide 2|NAP-2|NAP2|PPBP	Encoded by human PPBP Gene (Alpha Chemokine CXC Family), secreted 128-aa 14-kDa (precursor) Pro-Platelet Basic Protein is a platelet-derived growth factor that is processed to PBP and CTAP-III. Proteolytic removal of PPBP residues 1-9 produces active peptide CTAP-III/LA-PF4, which stimulates DNA synthesis, mitosis, glycolysis, intracellular cAMP accumulation, prostaglandin E2 secretion, and synthesis of hyaluronic acid and sulfated glycosaminoglycan, as well as formation and secretion of plasminogen activator. Upon platelet activation, PBP is proteolytically converted to beta thromboglobulin, a homotetramer released when platelets aggregate; CTAP-III is proteolytically converted to NAP2, a potent chemoattractant and activator of neutrophils. (NCI)
C26615	Adrenergic_Alpha-1A-Receptor	Retired_Concepts	Adrenergic, Alpha-1A-, Receptor|ADRA1A|Adrenergic, Alpha-1C-, Receptor
C26616	RRM2_Gene	Ribonucleotide_Reductase_Subunit_Gene	RRM2 Gene|R2 Gene|RR2 Gene|RRM2|Ribonucleoside-Diphosphate Reductase M2 Chain Gene|Ribonucleotide Reductase M2 Polypeptide Gene|Ribonucleotide Reductase Small Chain Gene	The RRM2 gene at 2p25-p24 encodes Ribonucleoside-Diphosphate Reductase M2 Chain, which is a subunit of ribonucleoside-diphosphate reductase, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Synthesis of M2 is regulated in a cell-cycle dependent fashion. Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as M2 subunits. RRM2 gene amplification from a homogeneous staining chromosome region and altered transcription regulation is associated with drug resistance. (From LocusLink and NCI)
C26617	_2p25-p24	Chromosome_Band	2p25-p24	A chromosome band present on 2p
C26618	Alpha_Granule	Other_Anatomic_Concept	Alpha Granule|Platelet Granule	Granules found in several types of cells, especially platelets, where they are the most numerous type of granule; contain secretory proteins.
C26619	ANG_Gene	Hydrolase_Gene	ANG Gene|ANG|Angiogenin, Ribonuclease, RNase A Family, 5 Gene|RNASE5	Angiogenin is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease (RNS1). (LocusLink)
C26620	_14q11_1-q11_2	Chromosome_Band	14q11.1-q11.2	A chromosome band present on 14q
C26621	Ribonucleoside-Diphosphate_Reductase-M2_Chain	Ribonucleotide_Reductase_Subunit	Ribonucleoside-Diphosphate Reductase M2 Chain|EC 1.17.4.1|R2|RR2|RRM2|RRM2 Protein|Ribonucleotide Reductase M2 Polypeptide|Ribonucleotide Reductase Small Chain|Ribonucleotide Reductase, M2 Subunit|Ribonucleotide Reductase, R2 Subunit|Ribonucleotide Reductase, Small Subunit	Ribonucleoside-Diphosphate Reductase M2 Chain, encoded by the RRM2 gene, is a subunit of ribonucleoside-diphosphate reductase, a heterodimeric cytoplasmic enzyme essential in dividing cells that reduces ribonucleotides to deoxyribonucleotide precursors for DNA synthesis in S phase. Enzyme activity closely correlates with the cellular rate of growth and appears to vary with the cell cycle. A substrate specificity site and a catalytic activity site regulate enzyme activity. A substrate-binding catalytic site on M1 is only formed in the presence of M2. Synthesis of M2 is regulated in a cell-cycle dependent fashion. Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as M2 subunits. RRM2 gene amplification from a homogeneous staining chromosome region and altered transcription regulation is associated with drug resistance. (From LocusLink and NCI)
C26623	CASP8_Gene	Caspase_Gene	CASP8 Gene|Apoptotic Cysteine Protease Gene|Apoptotic Protease MCH-5 Gene|CAP4|CASP8|Caspase 8, Apoptosis-Related Cysteine Protease Gene|Caspase-8 Gene|FADD-Homologous ICE/CED3-Like Protease Gene|FADD-Like ICE Gene|FLICE|ICE-Like Apoptotic Protease 5 Gene|MACH|MACH-Alpha-1/2/3 Protein Gene|MACH-Beta-1/2/3/4 Protein Gene|MCH5|MCH5 Isoform Alpha Gene|MORT1-Associated CED-3 Homolog Gene|MORT1-Associated CED3 Homolog Gene	The CASP8 gene at 2q33-q34 encodes Caspase-8, a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. Caspase-8 is involved in the programmed cell death induced by Fas and various apoptotic stimuli. This protein is detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicates its role in neurodegenerative diseases. Alternative splicing of this gene results in five transcript variants. (From LocusLink and NCI)
C26625	Interferon_Regulatory_Factor-3	Transcription_Factor	Interferon Regulatory Factor 3|IRF3	IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. (from LocusLink)
C26626	Interferon_Regulatory_Factor-2	Transcription_Factor	Interferon Regulatory Factor 2|IRF2	Encoded by human IRF2 Gene (IRF Family), transcription factor Interferon Regulatory Factor 2 competitively inhibits IRF1-transcriptional activation of interferons alpha and beta, and perhaps other IRF1-activated genes. IRF2 also functions as a transcriptional activator of histone H4. (NCI)
C26627	Interferon_Regulatory_Factor-1	Transcription_Factor	Interferon Regulatory Factor 1|IRF1	Encoded by human IRF1 Gene (IRF Family), transcription factor Interferon Regulatory Factor 1 activates transcription of interferon genes alpha and beta, as well as genes induced by interferons alpha, beta, and gamma. IRF1 also regulates apoptosis and tumor-suppression. (NCI)
C26628	_3p25_3	Chromosome_Band	3p25.3	A chromosome band present on 3p
C26629	_12q14_1	Chromosome_Band	12q14.1	A chromosome band present on 12q
C26630	POR_Gene	Oxidoreductase_Gene	POR Gene|CYPOR|P450 (Cytochrome) Oxidoreductase Gene|POR	Mammalian NADPH-cytochrome P450 reductase (CPR) was first identified by Horecker in 19501 as an NADPH-specific cytochrome c reductase.  CPR was linked to the microsomal electron transport chains, cytochromes P450 and b5, involved in drug and steroid hydroxylations in 1960's.  CPR is a flavoprotein containing both FAD and FMN.  It has a modular structure suggestive of its evolution from smaller subunits similar to flavodoxins and ferredoxin NADP+ reductase, and its 3-dimensional structure was recently determined.  It is involved in heme catabolism, sterol, bile acid synthesis and fatty acid metabolism.  CPR is also a component of nitric oxide synthases and methionine synthase reductase. (http://www.uky.edu/Pharmacy/ps/porter/CPR.htm)
C26631	_7q11_2	Chromosome_Band	7q11.2	A chromosome band present on 7q
C26632	Follistatin-Like-3_Glycoprotein	Ligand_Binding_Protein	Follistatin-Like 3 Glycoprotein|FSTL3|Follistatin-Related Protein	Secreted Follistatin-Like 3 Glycoprotein binds to activin and is highly homologous to follistatin, an activin ligand. It is a member of the follistatin-module protein family, which is composed of extracellular matrix-associated glycoproteins thought to act in a paracrine manner to bind morphogens or growth/differentiation factors and regulate their activity during development. In addition to the t(11;19) translocation in a case of B-cell chronic lymphocytic leukemia from which FSTL3 was isolated, rearrangement of the FSTL3 gene was also observed in a case of B-cell non-Hodgkin lymphoma and in a case of B-cell mantle zone lymphoma, suggesting that FSTL3 may be involved in the leukemogenesis process.(OMIM)
C26633	Drug_Metabolism	Xenobiotic_Metabolism	Drug Metabolism	Drug Metabolism involves a series of cellular biotransforming chemical modifications of a drug compound by enzymatic activity.
C26634	BAI1-Associated_Protein-2	Ligand_Binding_Protein	BAI1-Associated Protein 2|BAIAP2|Brain-Specific Angiogenesis Inhibitor Binding Protein	Encoded by human BAIAP2 Gene, Brain-Specific Angiogenesis Inhibitor Binding Protein interacts at the cytoplasmic membrane with brain-specific angiogenesis inhibitor, which may be involved in neuronal growth-cone guidance. BAIAP2 protein functions as an insulin receptor tyrosine kinase substrate and interacts with the dentatorubral-pallidoluysian atrophy gene, associated with a neurodegenerative disease. BAIAP2 also associates with a downstream effector of Rho small G proteins, which is associated with the formation of stress fibers and cytokinesis. (NCI)
C26635	BLNK_Gene	Adaptor_Signaling_Protein_Gene	BLNK Gene|B-Cell Linker Gene|BLNK|BLNK-s|Ly57|SLP-65|SLP65	The BLNK gene at 10q23.2-q23.33 encodes B-Cell Linker, which is essential for normal B-cell development. BLNK interfaces the B-cell receptor-associated SYK tyrosine kinase with PLC-gamma, the VAV guanine nucleotide exchange factor, and the GRB2 and NCK adaptor proteins. Tyrosine phosphorylation of BLNK by SYK provides docking sites for these SH2-containing effector molecules that, in turn, permits the phosphorylation and/or activation of their respective signaling pathways. Thus, BLNK represents a central linker protein that bridges the B-cell receptor-associated kinases with a multitude of signaling pathways and may regulate biologic outcomes of B-cell function and development. The somatic loss of the BLNK gene and the accompanying block in pre-B-cell differentiation might be one of the primary causes of childhood pre-B ALL. (From OMIM and NCI)
C26636	B-Cell_Linker	Adaptor_Signaling_Protein	B-Cell Linker|B Cell Linker Protein|B-Cell Linker Protein|BLNK	B-Cell Linker, encoded by the BLNK gene, is essential for normal B-cell development.  This protein interfaces the B-cell receptor-associated SYK tyrosine kinase with PLC-gamma, the VAV guanine nucleotide exchange factor, and the GRB2 and NCK adaptor proteins.  Tyrosine phosphorylation of B-Cell Linker by SYK provides docking sites for these SH2-containing effector molecules that, in turn permits the phosphorylation and/or activation of their respective signaling pathways.  Thus, B-Cell Linker represents a central linker protein that bridges the B-cell receptor-associated kinases with a multitude of signaling pathways and may regulate biologic outcomes of B-cell function and development.  The somatic loss of the BLNK gene and the accompanying block in pre-B-cell differentiation might be one of the primary causes of childhood pre-B ALL.  (From OMIM and NCI)
C26637	Immunoglobulin_Binding_Protein-1	Immunoglobulin_Binding_Protein	Immunoglobulin Binding Protein 1|Alpha 4 Protein|B Cell Signal Transduction Molecule Alpha 4|CD79A-Binding Protein 1|IGBP1|Immunoglobulin (CD79A) Binding Protein 1	Ubiquitously expressed (highest in heart, skeletal muscle, and pancreas) by human IGBP1 Gene, 339-aa 39-kDa Immunoglobulin Binding Protein 1 is likely involved in IgM/B-Cell Receptor signal transduction. Similar to mouse Igbp1 and yeast TAP42, IGBP1 contains potential N-glycosylation sites, myristylation sites, multiple potential PKC and casein kinase II phosphorylation sites, and an SH3-binding sequence-related stretch. IGBP1 associates with and likely regulates the activity of Ser/Thr phosphatase PP2A-Alpha and PP2A-Beta catalytic subunits. IGBP1 also associates with PP4 and PP6. (NCI)
C26638	Clofarabine	Purine_Antagonist|Ribonucleotide_Reductase_Inhibitor	Clofarabine|2-Chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)-9H-purin-6-amine|2-Chloro-9-(2-deoxy-2-fluoroarabinofuranosyl)adenine|Clofarex|clofarabine	A second generation purine nucleoside analog inhibiting DNA Polymerase and Ribonucleotide Reductase, causing inhibition of DNA and RNA synthesis, disruption of mitochondrial function, and apoptosis. (NCI)
C26639	Epoetin_Beta	Recombinant_Erythropoietin	Epoetin Beta	A recombinant therapeutic agent that is chemically identical to or similar to the endogenous cytokine human erythropoietin (EPO). Produced primarily by cells of the peritubular capillary endothelium of the kidney in response to hypoxia, circulating EPO binds to EPO receptors on the surface of committed erythroid progenitors in the bone marrow resulting in the replication and maturation of these progenitors to functional erythrocytes. (NCI04)
C26640	CMV_pp65_Peptide	Vaccine_Antigen	CMV pp65 Peptide	A peptide derived from cytomegalovirus (CMV) internal matrix protein pp65. CMV pp65 peptide antigen is used in recombinant vaccinia virus as an HLA-A-restricted epitope to produce vaccines and specific CD8+ and CD4+ cell responses against CMV infection, a serious complication of allogeneic bone marrow transplantation (BMT). In BMT, CMV infection may be prevented by passive immunization with donor-derived CMV-pp65-specific T-cell clones if provided early post-BMT. (NCI04)
C26641	Buspirone	Adjuvant_Analgesic	Buspirone Hydrochloride|BUSPIRONE HYDROCHLORIDE|Buspirone|Buspirone HCl	An anxiolytic agent chemically and pharmacologically unrelated to benzodiazepines, barbiturates, or other sedative/hypnotic drugs.  Although its exact mechanism of action is unknown, buspirone may exert its anti-anxiety effects via serotonin (5-HT1A) and dopamine receptors (D2) and may indirectly affect other neurotransmitter systems. Unlike typical benzodiazepine anxiolytics, this agent does not exert anticonvulsant or muscle relaxant effects and lacks prominent sedative effects. (NCI04)
C26642	Dexmethylphenidate	Miscellaneous_Adjuvant	Dexmethylphenidate|Focalin	The d-threo-enantiomer of methylphenidate, a central nervous system stimulant, appearing to block the reuptake of norepinephrine and dopamine into the presynaptic neuron, increasing their availability in the extracellular space.  The mechanism of action in Attention Deficit Hyperactivity Disorder is unknown. (NCI)
C26643	Dextroamphetamine-Amphetamine	Miscellaneous_Adjuvant	Dextroamphetamine-Amphetamine|Adderall|Adderall XR	A combination of two synthetic agents with central nervous system stimulant activity.  Both agents are non-catecholamine, sympathomimetic agents that elevate blood pressure and cause bronchodilation.  These agents are commonly abused psychostimulant drugs that induce psychologic dependence manifested by elevated mood, increased wakefulness, concentration, physical performance and a feeling of well-being.  Tolerance to various effects develops unequally, so that tachycardia and enhanced alertness diminish while psychotoxic effects (hallucinations and delusions) may occur. (NCI04)
C26644	E7389	Tubulin_Binding_Agent	E7389|E7389 (Halichondrin B Analog)	A synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. E7389 binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression. (NCI04)
C26645	EP-2101	Antineoplastic_Vaccine	EP-2101	A proprietary cancer DNA vaccine that contains multiple natural and modified epitopes derived from the four tumor associated antigens, CEA, HER2/neu, p53, and MAGE 2/3. EP-2101 also includes CAP1-6D, a heteroclitic CEA analog, and PADRE, a proprietary universal T-cell epitope that serves to enhance the immunogenicity of the epitopes.  This agent has been shown to elicit cytotoxic T-lymphocyte responses against tumor cells expressing these multiple epitopes. (NCI04)
C26646	EGb761	Antioxidant	EGb761	A standardized ginkgo biloba extract with antioxidant and neuroprotective activities.  EGb761 has been shown to inhibit the proliferation of certain tumor cells in vitro. (NCI04)
C26647	Black_Cohosh	Nutritional_Supplement	Black Cohosh|Remifemin	A triterpene-containing herb isolated from the roots and rhizomes of the plant Cimicifuga racemosa (also known as Actaea racemosa). While the mechanism of action of black cohosh is not completely understood, it appears to act as a selective estrogen receptor modulator.  In vitro, this preparation has been shown to induce cell cycle arrest and caspase-dependent apoptosis of estrogen-sensitive breast cancer cells. (NCI04)
C26648	CP-724_714	Tyrosine_Kinase_Inhibitor	CP-724,714	An orally bioavailable quinazoline with potential antineoplastic activity.  CP-724,714 selectively binds to the intracellular domain of HER2, reversibly inhibiting its tyrosine kinase activity and resulting in suppression of tumor cell growth.  HER2, a member of the epidermal growth factor receptor (EGFR) family, is overexpressed in many adenocarcinomas, particularly breast cancers. (NCI04)
C26649	Essiac	Nutritional_Supplement	Essiac	An herbal tea remedy thought to be an ancient Canadian Ojibway Indian formula containing burdock root, turkey rhubarb root, sheep sorel, and slippery elm bark.  The burdock root and turkey rhubarb root are claimed to have antitumor activity and herbalists believe the combination of herbs act synergistically to treat various cancers.  No formal clinical trials have been done and the formulation is not approved in Canada or the United States.(NCI)
C26650	Flaxseed	Nutritional_Supplement	Flaxseed|Flour, Flaxseed|Linseed	Seed isolated from one of several species of the plant genus Linum. Flaxseed-derived foods, lignans, and essential fatty acids such as alpha-linolenic acid, possess anti-inflammatory, lipid-lowering, antioxidant, and antineoplastic properties.
C26651	Ginseng	Nutritional_Supplement	Ginseng|Panax ginseng|ginseng	A Chinese herb derived from either the Panax ginseng, the Asian species, Panax quinquefolius, the American species, or P. pseudoginseng, known as Siberian or Russian ginseng, plant containing a complex mixture of saponins, ginsenosides and panaxosides, available as a nutritional supplement and is reported to enhance the immune system and reduce fatigue. (NCI)
C26652	GTI-2040	Antisense_Agent	GTI-2040	A 20-mer antisense oligonucleotide complementary to a coding region in the mRNA of the R2 small subunit component of human ribonucleotide reductase.  GTI-2040 decreases mRNA and protein levels of R2 in vitro and may inhibit tumor cell proliferation in human tumors in vivo. (NCI04)
C26653	GW572016	Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor	Lapatinib|GW 2016|GW2016|GW572016	A synthetic, orally-active quinazoline with potential antineoplastic properties. Lapatinib reversibly blocks phosphorylation of the epidermal growth factor receptor (EGFR), ErbB2, and the Erk-1 and-2 and AKT kinases; it also inhibits cyclin D protein levels in human tumor cell lines and xenografts.  EGFR and ErbB2 have been implicated in the growth of various tumor types.
C26654	Hexyl_5-Aminolevulinate	Photosensitizing_Agent	Hexyl 5-Aminolevulinate|HexvixR	The hexyl ester of 5-aminolevulinic acid (ALA) with photodynamic properties.  As a precursor of photoactive porphorins, hexyl 5-aminolevulinate induces the endogenous production of the photosensitizer protoporphyrin IX (PPIX) which accumulates selectively in tumor tissue.  When exposed to specific wavelengths of light, PPIX is activated and, depending on the wavelength and/or intensity of light, either fluoresces, thereby allowing tumor imaging, or induces tumor cell apoptosis. (NCI04)
C26655	Immucillin-H	Purine_Nucleoside_Phosphorylase_Inhibitor	Forodesine Hydrochloride|BCX-1777|Immucillin-H	The hydrochloride salt of the synthetic high-affinity transition-state analogue forodesine. Forodesine binds preferentially to and inhibits purine nucleotide phosphorylase (PNP), resulting in the accumulation of deoxyguanosine triphosphate and the subsequent inhibition of the enzyme ribonucleoside diphosphate reductase and DNA synthesis. This agent selectively causes apoptosis in stimulated or malignant T-lymphocytes. A transition state analogue is a substrate designed to mimic the properties or the geometry of the transition state of reaction.
C26656	Juven	Nutritional_Supplement	Juven	An orally bioavailable nutritional supplement. Juven contains the amino acids glutamine and arginine in addition to beta-hydroxy-beta-methylbutyrate (HMB). This agent may promote muscle protein synthesis and increase muscle mass. (NCI04)
C26657	Levocarnitine	Nutritional_Supplement	Levocarnitine|Carnitor|LEVOCARNITINE	An amino acid derivative.  Levocarnitine facilitates long-chain fatty acid entry into mitochondria, delivering substrate for oxidation and subsequent energy production. Fatty acids are utilized as an energy substrate in all tissues except the brain. (NCI04)
C26658	LY317615	Protein_Kinase_C_Inhibitor	LY317615|3-(1-Methyl-1H-indol-3-yl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-1H-indol-3-yl]-1H-pyrrole-2,5-dione Dihydrochloride	A synthetic macrocyclic bisindolemaleimide.  Binding to the ATP-binding site, LY317615 selectively inhibits protein kinase C beta, an enzyme involved in the induction of vascular endothelial growth factor (VEGF)-stimulated neo-angiogenesis. This agent may decrease tumor blood supply and so tumor burden. (NCI04)
C26659	Marijuana	Adjuvant_Analgesic|Antiemetic_Agent|Substance_of_Abuse	Marijuana	Any part of, or extract from, the female hemp plant Cannabis sativa.  Marijuana contains cannabinoids, substances with hallucinogenic, psychoactive, and addictive properties.  This agent has potential use for treating cancer pain and cachexia. (NCI04)
C26660	MLN2704	Immunoconjugate	MLN2704|MLN591DM1	An immunoconjugate that consists of a humanized monoclonal antibody (MLN591), directed against prostate-specific membrane antigen linked to a maytansinoid (DM1). The monoclonal antibody moiety of MLN2704 binds to tumor cells expressing prostate-specific membrane antigen; MLN274 is then internalized into the tumor cell where the DM1 maytansinoid moiety binds to tubulin and inhibits tubulin polymerization and microtubule assembly, resulting in a disruption of microtubule activity and cell division, and cell death. (NCI04)
C26661	Modafinil	Miscellaneous_Adjuvant	Modafinil|MODAFINIL|Provigil|modafinil	A drug that is being studied as a treatment for fatigue in patients with cancer.  It belongs to the family of drugs called stimulants.
C26662	Morinda_citrifolia	Nutritional_Supplement	Morinda citrifolia	A plant that yields various herbal preparations, including fruit juice (noni) and extracts from the root and leaf.  Noni juice has antioxidant properties, and may prevent tumorigenesis via inhibition of DNA-carcinogen adduct formation. (NCI04)
C26663	Pixantrone	Intercalating_Agent	Pixantrone	A synthetic noncardiotoxic aza-anthracenedione analogue. Pixantrone intercalates into DNA and induces topoisomerase II-mediated DNA strand crosslinks, resulting in inhibition of DNA replication and tumor cell cytotoxicity. (NCI04)
C26664	Camptothecin_Polyglutamate	Camptothecin	Camptothecin Polyglutamate|CT-2106|Polyglutamate Camptothecin|Polyglutamate PG-CPT	A therapeutic formulation consisting of camptothecin, an alkaloid isolated from the Chinese tree Camptotheca acuminata, conjugated with polyglutamate. During the S phase of the cell cycle, camptothecin selectively stabilizes topoisomerase I-DNA covalent complexes, thereby inhibiting religation of topoisomerase I-mediated single-strand DNA breaks and producing potentially lethal double-strand DNA breaks when encountered by the DNA replication machinery. Conjugation with polyglutamate renders this agent more water soluble and less toxic than the parent molecule. (NCI04)
C26665	Pomegranate_Juice	Antioxidant|Nutritional_Supplement	Pomegranate Juice	A natural juice isolated from the fruit of the plant Punica granatum with antioxidant, potential antineoplastic, and chemopreventive activities.  Pomegranate juice contains flavonoids which promote differentiation and apoptosis in tumor cells by down-regulating vascular endothelial growth factor (VEGF) and stimulating migration inhibitory factor (MIF), thereby inhibiting angiogenesis. The flavanoids in pomegranate juice also scavenge reactive oxygen species (ROS) and, in some cell types, may prevent ROS-mediated cell injury and death. (NCI04)
C26666	R-flurbiprofen	Chemopreventive_Agent	R-flurbiprofen|(R)-2-Fluoro-alpha-methyl[1,1'-biphenyl]-4-acetic Acid|Flurizan|R-Flurbiprofen	A substance that is being studied as a treatment for cancer. It belongs to the family of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).
C26667	Zileuton	Lipooxygenase_Inhibitor	Zileuton|(+-)-N-Hydroxy-N-(1-benzo[b]thien-2-ylethyl)-urea|N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea|ZILEUTON|Zyflo	A synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma. (NCI04)
C26668	RK-0202	Radioprotective_Agent	RK-0202	An oral polymer matrix-based rinse formulation that contains N-acetylcysteine, an antioxidant amino acid derivative with antiinflammatory properties. RK-0202 may alleviate symptoms of radiation-induced oral mucositis. (NCI04)
C26669	Seocalcitol	Differentiation_Inducer	Seocalcitol|(1R-(1alpha(1R*,2E,4E),3abeta,4E(1R*,3S*,5Z),7aalpha))-5-((1-(6-Ethyl-6-hydroxy-1-methyl-2,4-octadienyl)octahydro-7a-methyl-4H-inden-4-ylidene)ethylidene)-4-methylene-1,3-cyclohexanediol|1(S),3(R)-Dihydroxy-20(R)-(5'-ethyl-5'-hydroxyhepta-1'(E),3'(E)-dien-1'-yl)-9,10-secopregna-5(Z),7(E),10(19)-triene|EB1089	A vitamin D analogue, acting as a biological response modifier that inhibits cancer cell growth and induces cancer cell differentiation and apoptosis. (NCI)
C26670	Sildenafil_Citrate	Phosphodiesterase_Inhibitor	Sildenafil Citrate|SILDENAFIL CITRATE|Silenafil Citrate|Viagra	The citrate salt of a pyrazolopyrimidinone derivative structurally related to zaprinast. Sildenafil selectively inhibits cyclic guanosine monophosphate (cGMP)-specific type 5 phosphodiesterase, resulting in vasodilation in the corpus cavernosum of the penis and penile erection. (NCI04)
C26671	Silymarin	Antioxidant|Hepatoprotective_Agent	Silymarin	A mixture of flavonolignans isolated from the milk thistle plant Silybum marianum.  Silymarin may act as an antioxidant, protecting hepatic cells from chemotherapy-related free radical damage. This agent may also promote the growth of new hepatic cells. (NCI04)
C26672	Soblidotin	Tubulin_Binding_Agent	Soblidotin|TZT-1027	A dolastatin-10 derivative.  Soblidotin inhibits tubulin polymerization, resulting in cell cycle arrest and induction of apoptosis. (NCI04)
C26673	SU11248	Angiogenesis_Activator_Inhibitor|Signal_Transduction_Inhibitor|Tyrosine_Kinase_Inhibitor	SU11248|5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylic acid (2-diethylaminoethyl)amide)|SU011248	An orally bioavailable indolinone with potential antineoplastic activity.  SU11248 blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation.  This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells. (NCI04)
C26674	T900607	Tubulin_Binding_Agent	T900607	A pentafluorophenylsulfonamide compound with potential antineoplastic activity. T900607 inhibits tubulin polymerization by binding irreversibly to colchicine binding sites, resulting in cell cycle arrest and apoptosis. (NCI04)
C26675	Taporfin_Sodium	Photosensitizing_Agent	Taporfin Sodium|LS11	An agent consisting of chlorin e6, derived from chlorophyll, and L-aspartic acid with photosensitizing activity.  After intratumoral activation by light emitting diodes, taporfin sodium forms an extended high energy conformational state that generates singlet oxygen, resulting in free radical-mediated cell death. (NCI04)
C26676	Transferrin-CRM107	Immunotoxin	Transferrin-CRM107|HN-66000	A synthetic targeted protein toxin which consists of human transferrin (Tf) conjugated to a diphtheria toxin that contains a point mutation (CRM107). After binding to the transferrin receptor expressed on the tumor cell surface, transferrin-CRM107 is internalized, where the diphtheria toxin moiety exerts its cytotoxic effect intracellularly by inhibiting protein synthesis through ADP-ribosylation of elongation factor. (NCI04)
C26677	Virulizin	Immunostimulant	Virulizin	A natural biological response modifier (BRM) isolated from bovine reticuloendothelial tissue. Viruzlin may enhance cell-mediated immune response to tumor cells by direct macrophage activation. (NCI04)
C26678	YM598	Miscellaneous_Angiogenesis_Inhibitor	YM598	An orally active synthetic substituted phenylethenesulfonamide. As a selective endothelin A receptor antagonist, YM598 inhibits endothelin-mediated mechanisms involved in tumor cell growth and progression, angiogenesis, and metastasis. (NCI04)
C26679	GW786034	Retired_Concepts	GW786034
C26680	NY-ESO-B	Tumor_Antigen	NY-ESO-B	NY-ESO-1 is a tumor-associated antigen belonging to the family of immunogenic testicular proteins that are aberrantly expressed in human cancers in a lineage-nonspecific fashion. Reverse transcription-PCR analysis showed NY-ESO-1 mRNA expression in a variable proportion of a wide array of human cancers, including melanoma, breast cancer, bladder cancer, prostate cancer, and hepatocellular carcinoma; and restricted expression in normal tissues, with high-level mRNA expression found only in testis and ovary tissues. The gene for NY-ESO-1 maps to Xq28 and codes for an 18-kDa protein having no homology with any known protein. NY-ESO-1 elicits a strong, integrated humoral and cellular immune response in a high proportion of patients with NY-ESO-1-expressing tumors and is under investigation as a cancer immunotherapy agent.(NCI)
C26681	HPV_18E6	Human_Papilloma_Virus_Vaccine	HPV 18E6|HPV 18 E6:13-21	An immunogenic peptide derived from the human papillomavirus (HPV). Used to design prophylactic or therapeutic vaccines against HPV infection and HPV-related neoplasms, the HPV 18E6 peptide cross-reacts immunologically with both HPV type 16 and HPV type 18, the most common HPV types involved in cervical cancer. Vaccination with HPV 18E6 may result in increases in T cell-proliferative responses to HPV, as well as significant increases in cytokine responses to HPV antigens. (NCI04)
C26682	Abdominal_Pain	Pain	Abdominal Pain
C26683	Abnormal_Laboratory_Test	Lab_Finding	Abnormal Laboratory Test Result|Abnormal Lab Test Result|Abnormal Laboratory Test
C26684	Radiation-Induced_Abnormalities	Diseases_and_Disorders	Radiation-Related Disorder|Radiation-Induced Abnormalities|Radiation-Induced Abnormality
C26685	Premature_Separation_of_Placenta	Placental_Non-Neoplastic_Disorder	Premature Separation of Placenta|Abruptio Placentae
C26686	Abscess	Bacterial_Infection	Abscess|Bacterial Abscess|abscess	An enclosed collection of pus in tissues, organs, or confined spaces in the body.  An abscess is a sign of infection and is usually swollen and inflamed.
C26687	Acanthosis_Nigricans	Dermatitis	Acanthosis Nigricans
C26688	Acute_Laryngitis	Laryngitis	Acute Laryngitis
C26689	Addison_s_Disease	Adrenal_Cortical_Insufficiency	Addison's Disease	disease characterized by hypotension, weight loss, anorexia, weakness, and sometimes a bronze-like melanotic hyperpigmentation of the skin; due to tuberculosis or autoimmune induced disease (hypofunction) of the adrenal glands that results in deficiency of aldosterone and cortisol.
C26690	Adrenal_Gland_Disorder	Retroperitoneal_Disorder	Adrenal Gland Disorder|Adrenal Gland Disease|Adrenal Gland Diseases|Adrenal Gland Disorders
C26691	Adrenal_Gland_Insufficiency	Non-Neoplastic_Adrenal_Gland_Disorder|Non-Neoplastic_Endocrine_Disorder	Adrenal Gland Insufficiency
C26692	Factor_I_Deficiency	Coagulation_Factor_Deficiency	Factor I Deficiency	deficiency or absence of fibrinogen (coagulation factor I) in the blood.
C26693	Aneurysm	Cardiovascular_System_Finding	Aneurysm	protruding sac in the wall of a vein, artery, or heart, frequently caused by microbial infection; may present as pain, pressure on nearby organs, or cardiac weakening.
C26694	Dissecting_Aneurysm	Aneurysm	Dissecting Aneurysm
C26695	Anal_Disorder	Gastrointestinal_Disorder	Anal Disorder
C26696	Anxiety	Mental_and_Behavioral_Signs_and_Symptoms	Anxiety	Apprehension of danger and dread accompanied by restlessness, tension, tachycardia, and dyspnea unattached to a clearly identifiable stimulus.
C26697	Aortic_Aneurysm	Aneurysm	Aortic Aneurysm
C26698	Apnea	Alteration_in_Respiration|Non-Neoplastic_Lung_Disorder	Apnea	Transient cessation of respiration.
C26699	Bacterial_Arthritis	Arthritis|Bacterial_Infection|Bone_Infection	Bacterial Arthritis
C26700	Infective_Arthritis	Arthritis	Infective Arthritis
C26701	Septic_Arthritis	Bacterial_Arthritis	Septic Arthritis
C26702	Ataxia	Central_Nervous_System_Disorder	Ataxia|ataxia	Loss of muscle coordination.
C26703	Atrioventricular_Block	Heart_Block	Atrioventricular Block
C26704	Bacterial_Pneumonia	Bacterial_Infection|Pneumonia	Bacterial Pneumonia
C26705	Balanitis	Penile_Non-Neoplastic_Disorder	Balanitis
C26706	Bartholin_s_Cyst	Cyst|Reproductive_System_Finding	Bartholin's Cyst
C26707	Bladder_Stone	Urinary_Stone	Bladder Stone|Bladder Calculus|Cystolith
C26708	Eyelid_Ptosis	Ptosis	Eyelid Ptosis|ptosis	Drooping of the upper eyelid.
C26709	Breast_Disorder	Disorder_by_Site	Breast Disorder|Breast Disease|Breast Diseases
C26710	Bronchopneumonia	Pneumonia	Bronchopneumonia
C26711	Candidiasis	Fungal_Infection	Candidiasis|Candidosis	A condition in which Candida albicans, a type of yeast, grows out of control in moist skin areas of the body. It is usually a result of a weakened immune system, but can be a side effect of chemotherapy or treatment with antibiotics. Thrush usually affects the mouth (oral thrush); however, rarely, it spreads throughout the entire body.
C26712	Mucinous_Adenocarcinoma	Adenocarcinoma|Mucinous_Neoplasm	Mucinous Adenocarcinoma|Colloid Adenocarcinoma|Colloid Carcinoma|Gelatinous Adenocarcinoma|Gelatinous Carcinoma|Mucinous Carcinoma|Mucoid Adenocarcinoma|Mucoid Carcinoma|Mucous Adenocarcinoma|Mucous Carcinoma|mucinous carcinoma	(MYOO-sin-us kar-sin-O-ma) A type of cancer that begins in cells that line certain internal organs and produce mucin (the main component of mucus).
C26713	Cataract	Lens_Disorder|Non-Neoplastic_Eye_Disorder	Cataract	Partial or complete opacity of the crystalline lens of one or both eyes that decreases visual acuity and eventually results in blindness.  Some cataracts appear in infancy or in childhood, but most develop in older individuals. (Diagnostic Surgical Pathology, 3rd ed.) --2003
C26714	Celiac_Disease	Malabsorption_Syndrome	Celiac Disease|Celiac Sprue|Gluten-Induced Enteropathy|Non Tropical Sprue
C26715	Cellulitis	Bacterial_Infection	Cellulitis|cellulitis	An acute, spreading infection of the deep tissues of the skin and muscle that causes the skin to become warm and tender and may also cause fever, chills, swollen lymph nodes, and blisters.
C26716	Cervicitis	Cervical_Non-Neoplastic_Disorder	Cervicitis
C26717	Chalazion	Non-Neoplastic_Eyelid_Disorder	Chalazion
C26718	Cholangitis	Non-Neoplastic_Biliary_Tract_Disorder	Cholangitis
C26719	Chondrocalcinosis	Non-Neoplastic_Bone_Disorder	Chondrocalcinosis
C26720	Chorioamnionitis	Infectious_Disorder_by_Site|Placental_Non-Neoplastic_Disorder	Chorioamnionitis
C26721	Hemophilia_B	Hemophilia	Hemophilia B|Factor IX Deficiency
C26722	Chronic_Bronchitis	Bronchitis|Chronic_Obstructive_Airways_Disease	Chronic Bronchitis	condition characterized by persistent coughing, increased secretion from the bronchial mucosa, obstruction of the respiratory passages, scanty or profuse expectoration, and necrosis and fibrosis of the respiratory tract.
C26723	Colitis	Enteritis	Colitis|colitis	An acute or chronic inflammation of the colon caused by viruses (e.g. cytomegalovirus), bacteria (e.g. ameba) or immunologic factors (inflammatory bowel disease which includes Crohn's colitis and ulcerative colitis). -- 2004
C26724	Colles_Fracture	Upper_Extremity_Fracture	Colles' Fracture
C26725	Common_Variable_Immunodeficiency	Hypogammaglobulinemia	Common Variable Immunodeficiency|Acquired Agammaglobulinemia
C26726	Infectious_Disorder	Diseases_and_Disorders	Infectious Disorder|INFEC|Infection|Infectious Disease|Infectious Diseases|Infectious Diseases and Manifestations|infection	A disorder resulting from the presence and activity of a microbial, viral, or parasitic agent. It can be transmitted by direct or indirect contact. -- 2003
C26727	Transplanted_Organ_Complication	Transplant-Related_Disorder	Transplanted Organ Complication
C26728	Conjunctival_Haemorrhage	Eye_and_Ear_Finding|Hemorrhage	Conjunctival Hemorrhage
C26729	Connective_Tissue_Disorder	Connective_and_Soft_Tissue_Disorder	Connective Tissue Disorder|Bone Disorder|Connective Tissue Disease|Connective Tissue Diseases|Connective Tissue Disorders
C26730	Corneal_Abrasion	Corneal_Injury	Corneal Abrasion
C26731	Corneal_Disorder	Eye_Disorder	Corneal Disorder|Corneal Disease
C26732	Coronary_Disease	Non-Neoplastic_Heart_Disorder	Coronary Disease
C26733	Cranial_Nerve_Disorder	Nervous_System_Disorder	Cranial Nerve Disorder|Cranial Nerve Disease
C26734	Congenital_Hypothyroidism	Congenital_Thyroid_Disorder|Hypothyroidism	Congenital Hypothyroidism
C26735	Croup	Acute_Laryngitis	Croup|Acute Obstructive Laryngitis
C26736	Cryoglobulinemia	Immune_System_Disorder	Cryoglobulinemia	A condition characterized by the presence of cryoglobulins in the blood. Cryoglobulins are abnormal proteins that precipitate within the microvasculature on exposure to cold; microvasculature effects of cryoglobulinemia may result in restricted tissue blood flow, tissue hypoxia, and tissue necrosis. --2004
C26737	Cyanosis	Symptom	Cyanosis|cyanosis	Blue-colored skin caused by too little oxygen in the blood.
C26738	Cystitis	Non-Neoplastic_Bladder_Disorder	Cystitis
C26739	Sensorineural_Deafness	Deafness|Sensory_Hearing_Loss	Sensorineural Deafness
C26740	Dehydration	Fluid_and_Electrolyte_Manifestation	Dehydration|dehydration	A condition caused by the loss of too much water from the body.  Severe diarrhea or vomiting can cause dehydration.
C26741	Delusion	Mental_and_Behavioral_Signs_and_Symptoms	Delusion	False personal beliefs held contrary to reality, despite contradictory evidence and common sense.
C26742	Dermatitis_Herpetiformis	Dermatitis	Dermatitis Herpetiformis
C26743	Contact_Dermatitis	Dermatitis	Contact Dermatitis
C26744	Dermatomyositis	Autoimmune_Disease|Non-Neoplastic_Soft_Tissue_Disorder|Rheumatologic_Disorder	Dermatomyositis
C26745	Dermatophytosis	Dermatitis	Dermatophytosis
C26746	Scleroderma	Autoimmune_Disease|Rheumatologic_Disorder	Scleroderma|scleroderma	A chronic disorder marked by hardening and thickening of the skin.  Scleroderma can be localized or it can affect the entire body (systemic).
C26747	Non-Insulin_Dependent_Diabetes_Mellitus	Diabetes_Mellitus	Non-Insulin Dependent Diabetes Mellitus|Non-Insulin Dependent Diabetes
C26748	Diabetic_Neuropathy	Neuropathy	Diabetic Neuropathy
C26749	Vasoactive_Intestinal_Peptide_Producing_Neoplasm	Gastrointestinal_Neuroendocrine_Neoplasm	VIP Producing Tumor|VIP Producing Neoplasm|VIP- Secreting Neoplasm|VIP- Secreting Tumor|VIPoma|Vasoactive Intestinal Peptide Producing Neoplasm|Vasoactive Intestinal Peptide Producing Tumor|Vasoactive Intestinal Peptide Secreting Neoplasm	An often clinically aggressive endocrine neoplasm located in the pancreas or small intestine.  It is composed of cells containing vasoactive intestinal peptide.  It may cause intractable diarrhea and metabolic disturbances. --2003
C26750	Joint_Dislocation	Non-Neoplastic_Bone_Disorder	Joint Dislocation
C26751	Dissecting_Aortic_Aneurysm	Aortic_Aneurysm|Dissecting_Aneurysm	Dissecting Aortic Aneurysm
C26752	Diverticulitis	Non-Neoplastic_Gastrointestinal_Disorder	Diverticulitis
C26753	Diverticulum	Gastrointestinal_System_Finding	Diverticulum
C26754	Somnolence	Sleep_Disorder	Somnolence
C26755	Duodenal_Ulcer	Peptic_Ulcer	Duodenal Ulcer
C26756	Dyspepsia	Gastrointestinal_System_Signs_and_Symptoms	Dyspepsia|dyspepsia	Upset stomach.
C26757	Ear_Disorder	Head_and_Neck_Disorder	Ear Disorder|Ear Disease
C26758	Ecchymosis	Hemorrhage	Ecchymosis|ecchymosis	A small bruise caused by blood leaking from broken blood vessels into the tissues of the skin or mucous membranes.
C26759	Embolism	Non-Neoplastic_Vascular_Disorder	Embolism|embolism	(EM-bul-izm) A block in an artery caused by blood clots or other substances, such as fat globules, infected tissue, or cancer cells.
C26760	Encephalitis	Central_Nervous_System_Infectious_Disorder	Encephalitis
C26761	Encephalitis_Lethargica	Viral_Encephalitis	Encephalitis Lethargica
C26762	Endocervicitis	Cervicitis	Endocervicitis
C26763	Fallopian_Tube_Endometriosis	Endometriosis|Fallopian_Tube_Non-Neoplastic_Disorder	Fallopian Tube Endometriosis
C26764	Endometritis	Endometrial_Disorder|Genitourinary_System_Infection|Uterine_Corpus_Non-Neoplastic_Disorder	Endometritis
C26765	Enteritis	Intestinal_Disorder|Non-Neoplastic_Gastrointestinal_Disorder	Enteritis
C26766	Epistaxis	Hemorrhage	Epistaxis|Nasal Hemorrhage|Nosebleed	Bleeding from the nose.
C26767	Eye_Disorder	Disorder_by_Site	Eye Disorder|Eye Disease
C26768	Eyelid_Disorder	Eye_Disorder	Eyelid Disorder
C26769	Facial_Nerve_Paralysis	Cranial_Nerve_Paralysis|Facial_Nerve_Disorder	Facial Nerve Paralysis|Facial Palsy
C26770	Factor_XII_Deficiency	Coagulation_Factor_Deficiency	Factor XII Deficiency|Hageman Factor Deficiency
C26771	Fallopian_Tube_Disorder	Female_Reproductive_System_Disorder	Fallopian Tube Disorder|Fallopian Tube Disease
C26772	Fat_Necrosis	Morphologic_Finding	Fat Necrosis
C26773	Feminization	Endocrine_Syndrome	Feminization
C26774	Femur_Fracture	Lower_Extremity_Fracture	Femur Fracture
C26775	Flushing	Integumentary_System_Signs_and_Symptoms	Flushing	A sudden reddening of the face.
C26776	Solitary_Follicle_Cyst	Follicular_Cyst_of_Ovary	Solitary Follicular Cyst of Ovary|Solitary Follicle Cyst|Solitary Follicle Cyst of Ovary
C26777	Carpal_Bone_Fracture	Upper_Extremity_Fracture	Carpal Bone Fracture
C26778	Multiple_Fractures	Fracture	Multiple Fractures
C26779	Stress_Fracture	Fracture	Stress Fracture
C26780	Gastritis	Stomach_Disorder	Gastritis	Inflammation of the lining of the stomach.
C26781	Gastroesophageal_Reflux_Disease	Reflux	Gastroesophageal Reflux Disease|GERD|gastroesophageal reflux disease	(GAS-tro-eh-sof-a-JEE-al REE-flux diz-EEZ) Also called GERD. A common disorder marked by frequent or severe heartburn. The burning feeling occurs when stomach acid flows up into the esophagus.
C26782	Glaucoma	Non-Neoplastic_Eye_Disorder	Glaucoma	Increased pressure in the eyeball due to obstruction of the outflow of aqueous humor.
C26783	Gliosis	Morphologic_Finding	Gliosis	an excess of neuroglia in damaged areas of the central nervous system.
C26784	Glomerulonephritis	Nephritis	Glomerulonephritis
C26785	Goiter	Non-Neoplastic_Endocrine_Disorder|Non-Neoplastic_Thyroid_Gland_Disorder	Goiter|goiter	An enlarged thyroid. It may be caused by too little iodine in the diet or by other conditions. Most goiters are not cancer.
C26786	Gonadal_Disorder	Reproductive_System_Disorder	Gonadal Disorder|Gonadal Disorders
C26787	Gonococcal_Urethritis	Urethritis	Gonococcal Urethritis
C26788	Chronic_Granulomatous_Disease	Congenital_Disorder_of_Natural_Immunity	Chronic Granulomatous Disease|CGD
C26789	Granulomatous_Prostatitis	Prostate_Non-Neoplastic_Disorder	Granulomatous Prostatitis
C26790	Acute_Infective_Polyneuritis	Polyneuritis	Acute Infective Polyneuritis|Guillain Barre Syndrome|Guillain-Barre Syndrome	progressive ascending motor neuron paralysis of unknown etiology, frequently following an enteric or respiratory infection.
C26791	Hemorrhage	Other_Finding	Hemorrhage	Hemorrhage; flow of blood from a ruptured blood vessel.
C26792	Hemorrhoid	Anal_Disorder|Non-Neoplastic_Gastrointestinal_Disorder	Hemorrhoid|hemorrhoid	An enlarged or swollen blood vessel, usually located near the anus or the rectum.
C26793	Hepatic_Veno-Occlusive_Disease	Hepatic_Vascular_Disorder|Veno-Occlusive_Disease	Hepatic Veno-Occlusive Disease|hepatic veno-occlusive disease	A condition in which some of the veins in the liver are blocked. It is sometimes a complication of high-dose chemotherapy given before a bone marrow transplant and is marked by increases in weight, liver size, and blood levels of bilirubin.
C26794	Hip_Fracture	Lower_Extremity_Fracture	Hip Fracture
C26795	Humerus_Fracture	Upper_Extremity_Fracture	Humerus Fracture
C26796	Hydronephrosis	Obstructive_Uropathy	Hydronephrosis|hydronephrosis	Abnormal enlargement of a kidney, which may be caused by blockage of the ureter (such as by a kidney stone) or chronic kidney disease that prevents urine from draining into the bladder.
C26797	Hyperglycemia	Abnormal_Blood_and_Hematology_Test_Result	Hyperglycemia|hyperglycemia	A high level of blood sugar.  It is usually an indication of diabetes mellitus. --2003
C26798	Hypophosphatasia	Metabolic_Disorder	Hypophosphatasia
C26799	Factor_II_Deficiency	Coagulation_Factor_Deficiency	Factor II Deficiency
C26800	Hypothyroidism	Non-Neoplastic_Endocrine_Disorder|Non-Neoplastic_Thyroid_Gland_Disorder	Hypothyroidism|hypothyroidism	A condition in which the production of thyroid hormone by the thyroid gland is diminished. Signs and symptoms of hypothyroidism include low metabolic rate, tendency to weight gain, somnolence and sometimes myxedema. In the United States, the most common cause of hypothyroidism is Hashimoto's thyroiditis, an autoimmune disorder. SYN athyrea. --2004
C26801	Intestinal_Disorder	Gastrointestinal_Disorder	Intestinal Disorder
C26802	Creutzfeldt-Jacob_Disease	Spongiform_Encephalopathy	Creutzfeldt-Jacob Disease|CJD
C26803	Jaw_Fracture	Fracture	Jaw Fracture
C26804	Joint_Tuberculosis	Bone_Tuberculosis	Joint Tuberculosis
C26805	Keratitis	Non-Neoplastic_Corneal_Disorder	Keratitis	Inflammation of the cornea.
C26806	Keratoconus	Non-Neoplastic_Corneal_Disorder	Keratoconus
C26807	Renal_Stone	Urinary_Stone	Renal Stone|Kidney Calculus|Kidney Stone|Renal Calculus
C26808	Acute_Renal_Failure	Renal_Failure	Acute Renal Failure
C26809	Lacrimal_System_Disorder	Eye_Disorder	Lacrimal System Disorder
C26810	Laryngeal_Disorder	Neck_Disorder	Laryngeal Disorder|Laryngeal Disease
C26811	Laryngitis	Non-Neoplastic_Laryngeal_Disorder	Laryngitis|laryngitis	Inflammation of the larynx.
C26812	Lens_Disorder	Eye_Disorder	Lens Disorder
C26813	Acute_Eosinophilic_Leukemia	Acute_Myeloid_Leukemia	Acute Eosinophilic Leukemia	A poorly defined concept which at best is described as an extremely rare entity, possibly related to various subtypes of acute myeloid leukemia with abnormal eosinophils.  (WHO, 2001) -- 2003
C26814	Radiation-Related_Leukemia	Leukemia|Radiation-Related_Malignant_Neoplasm	Radiation-Related Leukemia|Radiation-Induced Leukemia	radiation induced progressive, malignant disease of the blood forming organs.
C26815	Progressive_Multifocal_Leukoencephalopathy	Leukoencephalopathy	Progressive Multifocal Leukoencephalopathy|PML	demyelination in various part of the central nervous system, usually secondary to neoplastic disease; JC virus has been recovered from brain tissue.
C26816	Leukopenia	Cytopenia	Leukopenia|leukopenia	(LOO-ko-PEE-nya) A condition in which the number of leukocytes (white blood cells) in the blood is reduced.
C26817	Lichen_Sclerosus_et_Atrophicus	Dermatitis	Lichen Sclerosus et Atrophicus
C26818	Lip_Disorder	Oral_Disorder	Lip Disorder|Lip Disease
C26819	Cutaneous_Lupus_Erythematosus	Lupus_Erythematosus	Cutaneous Lupus Erythematosus
C26820	Discoid_Lupus_Erythematosus	Cutaneous_Lupus_Erythematosus	Discoid Lupus Erythematosus
C26821	Lymphadenitis	Benign_Lymphoproliferative_Disorder|Lymph_Node_Disorder	Lymphadenitis|Adenitis
C26822	Lymphogranuloma_Venereum	Infectious_Disorder	Lymphogranuloma Venereum
C26823	Lymphopenia	Leukopenia	Lymphopenia	An abnormally small number of lymphocytes in the circulating blood.
C26824	Mandible_Fracture	Fracture	Mandible Fracture
C26826	Mediastinal_Disorder	Thoracic_Disorder	Mediastinal Disorder|Mediastinal Disease
C26827	Mediastinitis	Non-Neoplastic_Mediastinal_Disorder	Mediastinitis
C26828	Meningitis	Central_Nervous_System_Infectious_Disorder	Meningitis
C26829	Menorrhagia	Hemorrhage|Menstrual_Disorder	Menorrhagia|menorrhagia	Abnormally heavy menstrual bleeding.
C26830	Mesenteric_Lymphadenitis	Lymphadenitis	Mesenteric Lymphadenitis
C26831	Mycobacterial_Infection	Bacterial_Infection	Mycobacterial Infection
C26832	Myelitis	Central_Nervous_System_Infectious_Disorder	Myelitis
C26833	Nephritis	Non-Neoplastic_Renal_Disorder	Nephritis
C26834	Interstitial_Nephritis	Nephritis	Interstitial Nephritis
C26835	Nervous_System_Disorder	Disorder_by_Site	Nervous System Disorder
C26836	Nutritional_Disorder	Metabolic_Disorder	Nutritional Disorder
C26837	Osteogenesis_Imperfecta	Non-Neoplastic_Bone_Disorder	Osteogenesis Imperfecta
C26838	Osteomalacia	Non-Neoplastic_Bone_Disorder	Osteomalacia	A metabolic bone disease that results from either a deficiency in vitamin D, or an abnormality in the metabolism of vitamin D, or a deficiency of calcium in the diet.  The most common symptoms are bone pain and muscle weakness.  When it occurs in children it is commonly referred to as rickets. (Diagnostic Surgical Pathology, 3rd ed.) --2003
C26839	Bone_Infection	Infectious_Disorder_by_Site|Non-Neoplastic_Bone_Disorder	Bone Infection
C26840	Osteopetrosis	Non-Neoplastic_Bone_Disorder	Osteopetrosis
C26841	Ovarian_Disorder	Female_Reproductive_System_Disorder	Ovarian Disorder|Ovarian Disease
C26842	Pancreatic_Disorder	Gastrointestinal_Disorder	Pancreatic Disorder
C26843	Paranasal_Sinus_Disorder	Nasal_Cavity_and_Paranasal_Sinus_Disorder	Paranasal Sinus Disorder|Paranasal Sinus Disease
C26844	Parathyroid_Gland_Disorder	Neck_Disorder	Parathyroid Gland Disorder|Parathyroid Gland Disease|Parathyroid Gland Diseases|Parathyroid Gland Disorders
C26845	Parkinson_s_Disease	Non-Neoplastic_Central_Nervous_System_Disorder	Parkinson's Disease|Parkinson's disease	A progressive disorder of the nervous system marked by muscle tremors, muscle rigidity, decreased mobility, stooped posture, slow voluntary movements, and a mask-like facial expression.
C26846	Penile_Disorder	Male_Reproductive_System_Disorder	Penile Disorder|Penile Disease
C26847	Polyarteritis_Nodosa	Vasculitis	Polyarteritis Nodosa
C26848	Peritoneal_Disorder	Peritoneal_and_Retroperitoneal_Disorder	Peritoneal Disorder|Peritoneal Disease
C26849	Peritonitis	Non-Neoplastic_Peritoneal_Disorder	Peritonitis
C26850	Pharyngeal_Disorder	Neck_Disorder	Pharyngeal Disorder
C26851	Pharyngitis	Non-Neoplastic_Pharyngeal_Disorder	Pharyngitis
C26852	Phimosis	Penile_Non-Neoplastic_Disorder	Phimosis
C26853	Pituitary_Apoplexy	Non-Neoplastic_Pituitary_Gland_Disorder	Pituitary Gland Apoplexy|Pituitary Apoplexy
C26854	Pituitary_Gland_Disorder	Skull_Disorder	Pituitary Gland Disorder|Pituitary Gland Disease
C26855	Pityriasis_Rosea	Dermatitis	Pityriasis Rosea
C26856	Placenta_Accreta	Placental_Non-Neoplastic_Disorder	Placenta Accreta
C26857	Placenta_Disorder	Female_Reproductive_System_Disorder	Placenta Disorder|Placenta Disease|Placenta Diseases|Placenta Disorders
C26858	Placenta_Previa	Placental_Non-Neoplastic_Disorder	Placenta Previa	A condition in which the placenta is implanted in the lower part of the uterus. --2003
C26859	Pleural_Disorder	Thoracic_Disorder	Pleural Disorder|Pleural Disease|Pleural Disorders
C26860	Pleuritis	Pleural_Disorder	Pleuritis|Pleurisy
C26861	Pneumoconiosis	Non-Neoplastic_Lung_Disorder	Pneumoconiosis	any of a group of lung diseases resulting from inhalation of particles of industrial substances.
C26862	Stein-Leventhal_Syndrome	Polycystic_Ovarian_Disease	Stein-Leventhal Syndrome	clinical symptom complex characterized by presence of multiple cysts on the ovaries, oligomenorrhea or amenorrhea, anovulation and regularly associated with excessive amounts of body hair (hirsuitism), excessive body weight, infertility and insulin resistance.
C26863	Polycythemia	Hematologic_Disorder	Polycythemia
C26864	Polyneuritis	Peripheral_Nervous_System_Infectious_Disorder|Polyneuropathy	Polyneuritis|polyneuritis	Inflammation of several peripheral nerves at the same time.
C26865	Prostate_Disorder	Male_Reproductive_System_Disorder	Prostate Disorder|Prostate Disease
C26866	Prostatitis	Prostatic_Infection	Prostatitis|prostatitis	Inflammation of the prostate gland.
C26867	Kimura_s_Disease	Rare_Disorder	Kimura's Disease|Kimura Disease
C26868	Pulmonary_Edema	Acute_Respiratory_Failure	Pulmonary Edema	extravascular accumulation of fluid in the pulmonary tissue and air spaces.
C26869	Pulmonary_Fibrosis	Non-Neoplastic_Lung_Disorder	Pulmonary Fibrosis
C26870	Thrombocytopenic_Purpura	Hematologic_Disorder	Thrombocytopenic Purpura
C26871	Respiratory_Disorder	Respiratory_and_Thoracic_Disorder	Respiratory Disorder
C26872	Respiratory_Failure	Non-Neoplastic_Lung_Disorder	Respiratory Failure
C26873	Infectious_Lung_Disorder	Infectious_Disorder_by_Site|Non-Neoplastic_Lung_Disorder	Infectious Lung Disorder|Infectious Lung Disease|Infectious Lung Diseases|Infectious Lung Disorders
C26874	Retinal_Detachment	Retinal_Detachment_and_Defect	Retinal Detachment
C26875	Retinal_Disorder	Eye_Disorder	Retinal Disorder|Retinal Disease
C26876	Retroperitoneal_Fibrosis	Non-Neoplastic_Retroperitoneal_Disorder	Retroperitoneal Fibrosis
C26877	Rheumatism	Non-Neoplastic_Connective_and_Soft_Tissue_Disorder	Rheumatism|Musculoskeletal Pain Disorder|rheumatism	A group of disorders marked by inflammation or pain in the connective tissue structures of the body. These structures include bone, cartilage, and fat.
C26878	Rickets	Non-Neoplastic_Bone_Disorder	Rickets
C26879	Salivary_Gland_Disorder	Head_and_Neck_Disorder	Salivary Gland Disorder|Salivary Gland Disease	A non-neoplastic or neoplastic (benign or malignant) disorder involving the salivary gland. -- 2003
C26880	Salpingitis	Adnexitis|Fallopian_Tube_Non-Neoplastic_Disorder	Salpingitis	inflammation of the fallopian tubes.
C26881	Solar_Lentigo	Pre-Malignant_Skin_Epithelial_Lesions	Solar Lentigo|Lentigo Senilis
C26882	Sialoadenitis	Non-Neoplastic_Salivary_Gland_Disorder	Sialoadenitis
C26883	Sjogren_s_Syndrome	Autoimmune_Disease|Salivary_Gland_Disorder|Syndrome	Sjogren's Syndrome
C26884	Sleep_Apnea	Syndrome	Sleep Apnea	cessation of breathing for 10 seconds or more during sleep and consequent oxygen desaturation.
C26885	Testicular_Torsion	Testicular_Non-Neoplastic_Disorder	Testicular Torsion
C26886	Stomach_Disorder	Gastrointestinal_Disorder	Stomach Disorder
C26887	Stomatitis	Non-Neoplastic_Oral_Cavity_Disorder	Stomatitis|stomatitis	Inflammation of the oral mucosa due to local or systemic factors. -- 2003
C26889	Sinus_Tachycardia	Arrhythmia	Sinus Tachycardia
C26890	Testicular_Disorder	Male_Reproductive_System_Disorder	Testicular Disorder|Testicular Disease
C26891	Thrombosis	Non-Neoplastic_Vascular_Disorder	Thrombosis|thrombosis	(throm-BOW-sis) The formation or presence of a blood clot inside a blood vessel.
C26892	Thymic_Cyst	Mediastinal_Cyst	Thymic Cyst
C26893	Thyroid_Gland_Disorder	Neck_Disorder	Thyroid Gland Disorder|Thyroid Gland Disease|Thyroid Gland Diseases|Thyroid Gland Disorders
C26894	Thyroiditis	Non-Neoplastic_Endocrine_Disorder|Non-Neoplastic_Thyroid_Gland_Disorder	Thyroiditis
C26895	Tuberculous_Laryngitis	Laryngitis|Tuberculosis	Tuberculous Laryngitis
C26896	Lymph_Node_Tuberculosis	Tuberculosis	Lymph Node Tuberculosis
C26897	Bone_Tuberculosis	Tuberculosis	Bone Tuberculosis
C26898	Tuberculosis_of_Pleura	Non-Neoplastic_Pleural_Disorder|Pleuritis|Tuberculosis	Tuberculous Pleuritis|Tuberculosis of Pleura
C26899	Lung_Tuberculosis	Infectious_Lung_Disorder|Tuberculosis	Lung Tuberculosis|Lung TB|Pulmonary TB|Pulmonary Tuberculosis
C26900	Turner_s_Syndrome	Endocrine_Syndrome|Non-Neoplastic_Gonadal_Disorder	Turner's Syndrome|Gonadal Dysgenesis	genetic disease that produces sterile females due to monosomy for X chromosome; the ovaries are rudimentary or missing; other abnormalities include short stature, webbed neck, and a broad chest with widely spaced nipples.
C26901	Erythema	Skin_Discoloration	Erythema|erythema	Redness of the skin.
C26902	Ureteric_Calculus	Urinary_Stone	Ureteric Stone|Ureteric Calculus
C26903	Urethra_Disorder	Urinary_Tract_Disorder	Urethra Disorder|Urethra Disease
C26904	Urethritis	Non-Neoplastic_Urethra_Disorder	Urethritis
C26905	Urinary_Stone	Stone|Urinary_Tract_Finding	Urinary Stone|Urinary Calculus|Urolith
C26906	Urinary_Frequency	Genitourinary_Signs_and_Symptoms|Urinary_Tract_Finding	Urinary Frequency	urination at short intervals; it may result from increased urine formation, decreased bladder capacity, or lower urinary tract irritation.
C26907	Uterine_Disorder	Female_Reproductive_System_Disorder	Uterine Disorder|Uterine Disease
C26908	Uveal_Disorder	Eye_Disorder	Uveal Disorder|Uveal Disease
C26909	Uveitis	Non-Neoplastic_Uveal_Disorder	Uveitis
C26910	Vaginal_Disorder	Female_Reproductive_System_Disorder	Vaginal Disorder|Vaginal Disease
C26911	Vaginitis	Vaginal_Non-Neoplastic_Disorder	Vaginitis	Inflammation of the vagina.
C26912	Vasculitis	Non-Neoplastic_Vascular_Disorder	Vasculitis	Inflammation of a blood vessel.
C26913	Verruca_Plantaris	Benign_Verrucous_Lesion	Verruca Plantaris
C26914	Virilism	Endocrine_Syndrome	Virilism	abnormal development of secondary male sexual characteristics such as facial hair; in females, can be caused by androgen secretion by adrenal cortex.
C26915	Vitiligo	Dermatitis	Vitiligo
C26916	Anticipatory_Vomiting	Anticipatory_Nausea_and_Vomiting|Vomiting	Anticipatory Vomiting
C26917	Dry_Mouth	Symptom	Dry Mouth|Xerostomia|xerostomia	An oral condition in which salivary flow is reduced. --2004
C26918	AIDS-Related_Nephropathy	Diseases_Associated_with_AIDS|Focal_Segmental_Glomerulosclerosis	HIV-Associated Nephropathy|AIDS-Associated Nephropathy|AIDS-Related Nephropathy	Renal syndrome in human immunodeficiency virus-infected patients characterized by nephrotic syndrome, severe proteinuria, focal and segmental glomerulosclerosis with distinctive tubular and interstitial changes, enlarged kidneys, and peculiar tubuloreticular structures. The syndrome is distinct from heroin-associated nephropathy as well as other forms of kidney disease seen in HIV-infected patients.
C26919	Lymphosarcoma	Hematopoietic_and_Lymphoid_Neoplasms_Antiquated	Lymphosarcoma|lymphosarcoma	An obsolete term for a malignant tumor of lymphatic tissue.
C26920	Encephalopathy	Non-Neoplastic_Central_Nervous_System_Disorder	Encephalopathy|encephalopathy	A disorder of the brain that can be caused by disease, injury, drugs, or chemicals.
C26921	Fever_Chills	Chills	Fever Chills
C26922	Hepatic_Failure	Hepatic_Disorder	Hepatic Failure	The failure of the liver to detoxify chemicals in the body leading to a clinical disease
C26923	Sinus_Bradycardia	Arrhythmia	Sinus Bradycardia
C26924	Ventricular_Arrhythmia	Arrhythmia	Ventricular Arrhythmia	Irregular heart beat resulting from a pathologic process in the cardiac ventricles.--2004
C26925	Polymyositis	Dermatomyositis|Myositis	Polymyositis
C26926	Alcoholic_Polyneuropathy	Toxic_Polyneuropathy	Alcoholic Polyneuropathy
C26927	Hydroureter	Obstructive_Uropathy|Ureter_Disorder	Hydroureter|hydroureter	Abnormal enlargement of the ureter caused by any blockage that prevents urine from draining into the bladder.
C26928	Hemorrhagic_Gastritis	Gastritis	Hemorrhagic Gastritis
C26929	Chronic_Gastritis	Gastritis	Chronic Gastritis
C26930	Chronic_Prostatitis	Prostatitis	Chronic Prostatitis
C26931	Hypogammaglobulinemia	Deficiency_of_Humoral_Immunity	Hypogammaglobulinemia
C26932	Acute_Bronchitis	Bronchitis|Infectious_Lung_Disorder	Acute Bronchitis
C26933	Acute_Gastritis	Gastritis	Acute Gastritis
C26934	Acute_Cystitis	Cystitis	Acute Cystitis
C26935	Acute_Prostatitis	Prostatitis	Acute Prostatitis
C26936	Prostatic_Stone	Reproductive_System_Finding|Stone	Prostatic Stone|Prostate Calculus|Stone of Prostate
C26937	Cervical_Lymphadenitis	Lymphadenitis	Cervical Lymphadenitis
C26938	Fibula_Fracture	Lower_Extremity_Fracture	Fibula Fracture
C26939	Coccyx_Fracture	Fracture	Coccyx Fracture
C26940	Chronic_Pain	Pain	Chronic Pain|chronic pain	Pain that can range from mild to severe, and persists or progresses over a long period of time.
C26941	Cranial_Nerve_Paralysis	Cranial_Nerve_Disorder	Cranial Nerve Paralysis
C26942	Thyroid_Atrophy	Non-Neoplastic_Endocrine_Disorder|Non-Neoplastic_Thyroid_Gland_Disorder	Thyroid Gland Atrophy|Thyroid Atrophy
C26943	Gamma-Glutamyltransferase_Increased	Abnormal_Blood_and_Hematology_Test_Result	Gamma-Glutamyltransferase Increased	Increase in the level of the enzyme gamma-glutamyltransferase in the blood, which catalyzes the transfer of a gamma glutamyl group from a gamma glutamyl peptide to another peptide, aminoacids, or water. -- 2004
C26944	Retroperitoneal_Hemorrhage	Peritoneal_and_Retroperitoneal_Hemorrhage	Retroperitoneal Hemorrhage
C26945	Vaginal_Hemorrhage	Hemorrhage|Reproductive_System_Finding	Vaginal Hemorrhage
C26946	Hepatocellular_Damage	Hepatic_Disorder	Hepatocellular Damage
C26947	Aspartate_Aminotransferase_Increased	Abnormal_Blood_and_Hematology_Test_Result	Aspartate Aminotransferase Increased	An increase in the level of aspartate aminotransferase in the blood. -- 2003
C26948	Alanine_Aminotransferase_Increased	Abnormal_Blood_and_Hematology_Test_Result	Alanine Aminotransferase Increased	An increase in the level of alanine aminotransferase in the blood. -- 2003
C26949	Duodenal_Ulcer_Hemorrhage	Gastrointestinal_Hemorrhage	Duodenal Ulcer Hemorrhage
C26950	Esophageal_Ulcer	Esophageal_Disorder	Esophageal Ulcer
C26951	Polyneuropathy	Neuropathy	Polyneuropathy
C26952	Trigeminal_Nerve_Disorder	Cranial_Nerve_Disorder	Trigeminal Nerve Disorder
C26953	Disorder_of_the_11th_Nerve	Cranial_Nerve_Disorder	Accessory Nerve Disorder|Disorder of 11th Nerve|Disorder of the 11th Nerve|Eleventh Nerve Disorder
C26954	Hypoglossal_Nerve_Disorder	Cranial_Nerve_Disorder	Hypoglossal Nerve Disorder|Disorder of XII Nerve|Disorder of the XII Nerve|Twelfth Nerve Disorder
C26955	Familiar_Polycythemia	Polycythemia_Excluding_Polycythemia_Vera	Familiar Polycythemia
C26956	Hodgkin_s_Paragranuloma	Hodgkin_s_Lymphoma_Antiquated	Hodgkin's Paragranuloma
C26957	Tuberculous_Bronchiectasis	Lung_Tuberculosis	Tuberculous Bronchiectasis
C26958	Adrenal_Gland_Tuberculosis	Non-Neoplastic_Adrenal_Gland_Disorder|Tuberculosis	Adrenal Gland Tuberculosis
C26959	Reticulosarcoma_Involving_Spleen	Reticulosarcoma	Reticulosarcoma Involving Spleen
C26960	Lymphosarcoma_Involving_Spleen	Lymphosarcoma	Lymphosarcoma Involving Spleen
C26961	Hodgkin_s_Paragranuloma_Involving_Spleen	Hodgkin_s_Lymphoma_Antiquated	Hodgkin's Paragranuloma Involving Spleen
C26962	Thymus_Disorder	Thoracic_Disorder	Thymus Disorder
C26963	Carotenemia	Abnormal_Blood_and_Hematology_Test_Result	Carotenemia	A change in skin color due to deposition of carotene.
C26964	Selective_IgA_Immunodeficiency	Selective_Immunoglobulin_Isotype_Deficiency	Selective IgA Immunodeficiency
C26965	Selective_IgM_Immunodeficiency	Selective_Immunoglobulin_Isotype_Deficiency	Selective IgM Immunodeficiency
C26966	Chronic_Lymphadenitis	Lymphadenitis	Chronic Lymphadenitis
C26967	Retinal_Detachment_and_Defect	Non-Neoplastic_Retinal_Disorder	Retinal Detachment and Defect
C26968	Retinal_Defect	Retinal_Detachment_and_Defect	Retinal Defect
C26969	Corneal_Abscess	Abscess|Non-Neoplastic_Corneal_Disorder	Corneal Abscess
C26970	Bullous_Keratopathy	Keratopathy	Bullous Keratopathy
C26971	Dacryoadenitis	Lacrimal_System_Disorder|Non-Neoplastic_Eye_Disorder	Dacryoadenitis
C26972	External_Ear_Disorder	Ear_Disorder	External Ear Disorder
C26973	Sensory_Hearing_Loss	Hearing_Loss|Non-Neoplastic_Inner_Ear_Disorder	Sensory Hearing Loss|Sensorineural Hearing Loss
C26974	Mixed_Conductive_and_Sensorineural_Deafness	Deafness	Mixed Conductive and Sensorineural Deafness
C26975	Chronic_Laryngitis	Laryngitis	Chronic Laryngitis
C26976	Chronic_Obstructive_Asthma	Chronic_Obstructive_Airways_Disease	Chronic Obstructive Asthma
C26977	Alcoholic_Gastritis	Gastritis	Alcoholic Gastritis
C26978	Acute_Lymphadenitis	Lymphadenitis	Acute Lymphadenitis
C26979	Juvenile_Chronic_Polyarthritis	Polyarthritis	Juvenile Chronic Polyarthritis
C26980	Allergic_Arthritis	Arthritis	Allergic Arthritis
C26981	Climacteric_Arthritis	Arthritis	Climacteric Arthritis
C26982	Pathologic_Joint_Dislocation	Joint_Dislocation	Pathologic Joint Dislocation
C26983	Intervertebral_Disc_Degenerative_Disorder	Spinal_Degenerative_Disorder	Intervertebral Disc Degenerative Disorder|Intervertebral Disc Degeneration|Intervertebral Disc Degenerative Disease
C26984	Infective_Myositis	Myositis	Infective Myositis
C26985	Interstitial_Myositis	Myositis	Interstitial Myositis
C26986	Pharyngeal_Hemorrhage	Hemorrhage	Pharyngeal Hemorrhage
C26987	Clavicle_Fracture	Fracture	Clavicle Fracture
C26988	Forearm_Fracture	Upper_Extremity_Fracture	Forearm Fracture
C26989	Ankle_Fracture	Lower_Extremity_Fracture	Ankle Fracture
C26990	Transplanted_Kidney_Complication	Transplanted_Organ_Complication	Transplanted Kidney Complication|Complication of Transplanted Kidney
C26991	Transplanted_Liver_Complication	Transplanted_Organ_Complication	Transplanted Liver Complication|Complication of Transplanted Liver
C26992	Transplanted_Heart_Complication	Transplanted_Organ_Complication	Transplanted Heart Complication|Complication of Transplanted Heart
C26993	Transplanted_Lung_Complication	Transplanted_Organ_Complication	Transplanted Lung Complication|Complication of Transplanted Lung
C26994	Burn_of_Esophagus	Burn	Burn of Esophagus
C26995	Urethral_Stone	Urinary_Stone	Urethral Stone|Urethral Calculus
C26996	Polyarthritis	Arthritis	Polyarthritis
C26997	Hypertrophic_Scar	Reactive_Cutaneous_Fibrous_Lesions	Hypertrophic Scar
C26998	Allergic_Contact_Dermatitis	Contact_Dermatitis	Allergic Contact Dermatitis
C26999	Ruptured_Aneurysm	Aneurysm	Ruptured Aneurysm
C27000	Abdominal_Aortic_Aneurysm	Aortic_Aneurysm	Abdominal Aortic Aneurysm
C27001	Thoracic_Aortic_Aneurysm	Aortic_Aneurysm	Thoracic Aortic Aneurysm
C27002	Lower_Extremity_Fracture	Fracture	Lower Extremity Fracture
C27003	Acute_Pain	Pain	Acute Pain|acute pain	Pain that comes on quickly, can be severe, but lasts a relatively short time.
C27004	Sarcomatoid_Carcinoma	Carcinoma|Malignant_Spindle_Cell_Neoplasm	Sarcomatoid Carcinoma|Pseudosarcomatous Carcinoma|Spindle Cell Carcinoma	Cancer that arises in cells that appear spindle-shaped when viewed under a microscope. These cancers can occur in various places in the body, including the skin, lungs, kidney, breast, gastrointestinal tract, bone, and muscle.
C27005	Spindle_Cell_Sarcoma	Sarcoma_of_the_Soft_Tissue_and_Bone	Spindle Cell Sarcoma|spindle cell sarcoma	A malignant mesenchymal neoplasm composed of spindle-shaped cells.  This is a morphologic term which can be applied to a wide range of sarcomas. -- 2004
C27006	Interstitial_Pneumonitis	Pneumonia	Interstitial Pneumonia|Interstitial Pneumonitis
C27007	Spitz_Spindle_Cell_Nevus	Benign_Melanocytic_Nevus|Spindle_Cell_Neoplasm	Spitz (Spindle Cell) Nevus|Benign Juvenile Melanoma|Juvenile Nevus|Spindle Cell Nevus|Spindle and Epithelioid Cell Nevus|Spitz Nevus
C27008	Chronic_Cystitis	Cystitis	Chronic Cystitis
C27009	Myalgia	Pain	Myalgia|myalgia	(my-AL-juh) Pain in a muscle or group of muscles.
C27010	Sterile	Retired_Concepts	Sterile|sterile	The inability to produce children.
C27011	Euphoric_Mood	Mental_and_Behavioral_Signs_and_Symptoms	Euphoric Mood
C27012	Keratopathy	Non-Neoplastic_Corneal_Disorder	Keratopathy
C27013	Erosive_Gastritis	Gastritis	Erosive Gastritis
C27014	Chemical_Esophagitis	Esophagitis	Chemical Esophagitis
C27015	Granulomatous_Hepatitis	Hepatitis	Granulomatous Hepatitis
C27016	Submandibular_Lymphadenitis	Lymphadenitis	Submandibular Lymphadenitis
C27017	Aggravated_Arthritis	Arthritis	Aggravated Arthritis
C27018	Acquired_Hemangioma	Hemangioma	Acquired Hemangioma
C27019	Male_Reproductive_System_Disorder	Reproductive_System_Disorder	Male Reproductive System Disorder|Male Reproductive System Disease
C27020	Female_Reproductive_System_Disorder	Reproductive_System_Disorder	Female Reproductive System Disorder|Female Reproductive System Disease	note that mammary disorders are not treed under this heading.
C27021	Collagenous_Colitis	Microscopic_Colitis	Collagenous Colitis
C27022	Acute_Endometritis	Endometritis	Acute Endometritis
C27023	Herpes_Esophagitis	Viral_Esophagitis	Herpes Esophagitis
C27024	Selective_Immunoglobulin_G_Subclass_Deficiency	Deficiency_of_Humoral_Immunity	Selective Immunoglobulin G Subclass Deficiency
C27025	Ischemic_Neuropathy	Neuropathy	Ischemic Neuropathy
C27026	Talc_Pneumoconiosis	Pneumoconiosis	Talc Pneumoconiosis
C27027	Candida_Esophagitis	Candidiasis|Fungal_Esophagitis	Candida Esophagitis
C27028	Prolonged_Partial_Thromboplastin_Time	Abnormal_Hematology_Test_Result	Prolonged Partial Thromboplastin Time	An abnormal laboratory test result in which the partial thromboplastin time is found to be greater than the control value. As a possible indicator of coagulopathy, a prolonged partial thromboplastin time (PTT) may occur in a variety of diseases and disorders, both primary and related to treatment. --2004
C27029	Autoimmune_Hepatitis	Hepatitis	Autoimmune Hepatitis
C27030	Cerebral_Abscess	Central_Nervous_System_Infectious_Disorder|Intracranial_Abscess	Cerebral Abscess
C27031	Pancreatic_Endocrine_Neoplasm	Endocrine_Pancreas_Disorder|Gastrointestinal_Neuroendocrine_Neoplasm|Pancreatic_Neoplasm	Pancreatic Endocrine Tumor|Islet Cell Neoplasm|Islet Cell Tumor|Pancreatic Endocrine Neoplasm|Pancreatic Neuroendocrine Neoplasm|Pancreatic Neuroendocrine Tumor	An uncommon benign or malignant neoplasm, arising from the islet cells of the pancreas.  Based on the clinical manifestations, it is classified as functioning or non-functioning.
C27032	Anaplastic_Lymphoma_Kinase	Receptor_Tyrosine_Kinase	Anaplastic Lymphoma Kinase|ALK|Anaplastic Lymphoma Kinase Ki-1|CD246 Antigen	The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. (LocusLink)
C27033	Autonomic_Neuropathy	Neuropathy	Autonomic Neuropathy
C27034	Juvenile_Angiofibroma	Angiofibroma	Juvenile Angiofibroma
C27035	Lumbar_Vertebral_Fracture	Fracture	Lumbar Vertebral Fracture
C27036	Nerve_Paralysis	Paralysis	Nerve Paralysis
C27037	Spongiotic_Dermatitis	Dermatitis	Spongiotic Dermatitis
C27038	Hypereosinophilic_Syndrome	Syndrome	Hypereosinophilic Syndrome	A syndrome characterized by persistent eosinophilia, for which no underlying cause can be found, and which is associated with signs of organ involvement and dysfunction.  This term has often been applied to cases of chronic eosinophilic leukemia.  (WHO, 2001) -- 2003
C27039	Hemophilic_Arthritis	Arthritis	Hemophilic Arthritis
C27040	Spinal_Degenerative_Arthritis	Spinal_Degenerative_Disorder	Spinal Degenerative Arthritis
C27041	Neck_Arthritis	Arthritis	Neck Arthritis
C27042	Soft_Tissue_Disorder	Connective_and_Soft_Tissue_Disorder	Soft Tissue Disorder|Soft Tissue Disease|Soft Tissue Diseases|Soft Tissue Disorders
C27043	Acute_Respiratory_Failure	Respiratory_Failure	Acute Respiratory Failure
C27044	Eosinophilic_Endomyocardial_Disease	Heart_Disease	Eosinophilic Endomyocardial Disease
C27045	Nodal_Arrhythmia	Arrhythmia	Nodal Arrhythmia	Nodal arrhythmia is arrythmia occurring when the atrioventricular node or surrounding junctional tissue is acting as pacemaker.
C27046	Ruptured_Abdominal_Aortic_Aneurysm	Abdominal_Aortic_Aneurysm|Ruptured_Aortic_Aneurysm	Ruptured Abdominal Aortic Aneurysm
C27047	Connective_Tissue_Nevus	Retired_Concepts	Connective Tissue Nevus|Collagen Hamartoma|Collagen Nevus|Collagenoma
C27048	Congenital_Eyelid_Malformation	Congenital_Abnormality	Congenital Eyelid Malformation
C27049	Congenital_Eyelid_Ptosis	Congenital_Eyelid_Malformation|Eyelid_Ptosis	Congenital Eyelid Ptosis
C27050	Placenta_Malformation	Placental_Non-Neoplastic_Disorder	Placenta Malformation
C27051	Lymphocytic_Gastritis	Gastritis	Lymphocytic Gastritis
C27052	Eosinophilic_Gastritis	Eosinophilic_Gastroenteritis|Gastritis	Eosinophilic Gastritis
C27053	Eosinophilic_Colitis	Microscopic_Colitis	Eosinophilic Colitis
C27054	Rectal_Hemorrhage	Gastrointestinal_Hemorrhage	Rectal Hemorrhage	Discharge of blood from the anus. -- 2003
C27055	Uremic_Neuropathy	Neuropathy	Uremic Neuropathy
C27056	Acute_Cervicitis	Cervicitis	Acute Cervicitis
C27057	Chronic_Cervicitis	Cervicitis	Chronic Cervicitis
C27058	Brain_Damage	Non-Neoplastic_Central_Nervous_System_Disorder	Brain Damage
C27059	Leukoencephalopathy	Central_Nervous_System_Infectious_Disorder	Leukoencephalopathy	White matter changes first described in children with leukemia, associated with radiation and chemotherapy injury, often associated with methotrexate; pathologically characterised by diffuse reactive astrocytosis with multiple areas of necrotic foci without inflammation. (On-line Medical Dictionary)
C27060	Radiation-Induced_Myelopathy	Non-Neoplastic_Central_Nervous_System_Disorder|Radiation-Induced_Abnormalities	Radiation-Induced Myelopathy
C27061	Peroneal_Nerve_Paralysis	Non-Neoplastic_Peripheral_Nervous_System_Disorder	Peroneal Nerve Paralysis
C27062	Demyelinating_Polyneuropathy	Demyelinating_Disorder|Polyneuropathy	Demyelinating Polyneuropathy
C27063	Toxic_Polyneuropathy	Polyneuropathy	Toxic Polyneuropathy
C27064	Radiation-Induced_Cataract	Cataract|Radiation-Induced_Abnormalities	Radiation-Induced Cataract
C27065	Middle_Ear_Disorder	Ear_Disorder	Middle Ear Disorder
C27066	Pituitary_Necrosis	Non-Neoplastic_Pituitary_Gland_Disorder	Pituitary Gland Necrosis|Pituitary Necrosis
C27067	Endocrine_Pancreas_Disorder	Endocrine_Disorder|Pancreatic_Disorder	Endocrine Pancreas Disorder|Endocrine Pancreas Disease|Endocrine Pancreas Diseases|Endocrine Pancreas Disorders
C27068	Diabetic_Autonomic_Neuropathy	Autonomic_Neuropathy|Diabetic_Neuropathy	Diabetic Autonomic Neuropathy
C27069	Polycythemia_Neonatorum	Polycythemia_Excluding_Polycythemia_Vera	Polycythemia Neonatorum
C27070	Reticular_Dysgenesis	Congenital_Combined_Immunodeficiency	Reticular Dysgenesis
C27071	Transient_Hypogammaglobulinemia_of_Infancy	Transient_Hypogammaglobulinemia	Transient Hypogammaglobulinemia of Infancy
C27072	Finger_Fracture	Hand_Fracture	Finger Fracture
C27073	Cranial_Nerve_Injury	Nervous_System_Injury	Cranial Nerve Injury	Injury to, or disease of, the cranial nerve
C27074	Arthritis_or_Polyarthritis_due_to_Pneumococcus	Bacterial_Arthritis	Arthritis or Polyarthritis due to Pneumococcus
C27075	Arthritis_or_Polyarthritis_due_to_Streptococcus	Bacterial_Arthritis	Arthritis or Polyarthritis due to Streptococcus
C27076	Tuberculous_Ascites	Tuberculosis	Tuberculous Ascites
C27077	Arthritis_or_Polyarthritis_due_to_Pseudomonas	Bacterial_Arthritis	Arthritis or Polyarthritis due to Pseudomonas
C27078	Arthritis_or_Polyarthritis_due_to_Escherichia_Coli	Bacterial_Arthritis	Arthritis or Polyarthritis due to Escherichia Coli
C27079	Non-Gonococcal_Urethritis	Urethritis	Non-Gonococcal Urethritis
C27080	Refractory_Anemia_with_Excess_Blasts_in_Transformation	Hematopoietic_and_Lymphoid_Neoplasms_Antiquated	Refractory Anemia with Excess Blasts in Transformation|RAEB-T
C27081	Juvenile_Pilocytic_Astrocytoma	Childhood_Pilocytic_Astrocytoma	Juvenile Pilocytic Astrocytoma
C27082	Radiation-Induced_Cerebritis	Brain_Damage|Radiation-Induced_Abnormalities	Radiation-Induced Cerebritis
C27083	Blood_Clot	Cardiovascular_System_Finding	Blood Clot
C27084	Sarcomatoid_Squamous_Cell_Carcinoma	Sarcomatoid_Carcinoma|Squamous_Cell_Carcinoma	Sarcomatoid Squamous Cell Carcinoma|Epidermoid Spindle Cell Carcinoma|Spindle Cell (Sarcomatoid) Squamous Cell Carcinoma|Squamous Cell Carcinoma, Sarcomatoid|Squamous Cell Carcinoma, Spindle Cell|Squamous Cell Spindle Cell Carcinoma
C27085	Dissecting_Abdominal_Aortic_Aneurysm	Abdominal_Aortic_Aneurysm|Dissecting_Aortic_Aneurysm	Dissecting Abdominal Aortic Aneurysm
C27086	Polycystic_Ovarian_Disease	Ovarian_Non-Neoplastic_Disorder	Polycystic Ovarian Disease
C27087	Verruca_Vulgaris	Benign_Verrucous_Lesion	Verruca Vulgaris
C27088	Elevated_Bilirubin	Abnormal_Blood_and_Hematology_Test_Result	Elevated Bilirubin|Hyperbilirubinemia	Abnormally high level of bilirubin in the blood.  Excess bilirubin is associated with jaundice.
C27089	Vesicle	Other_Anatomic_Concept	Vesicle|VESCL	A closed structure surrounded by a single membrane.
C27090	Degenerative_Disorder	Diseases_and_Disorders	Degenerative Disorder|Degenerative Disease|degenerative disease	A disease in which the function or structure of the affected tissues or organs changes for the worse over time.  Osteoarthritis, osteoporosis, and Alzheimer's disease are examples.
C27091	Malignant_Spindle_Cell_Neoplasm	Spindle_Cell_Neoplasm	Malignant Spindle Cell Neoplasm|Malignant Spindle Cell Tumor|Spindle Cell Cancer|spindle cell cancer	Cancer that arises in cells that appear spindle-shaped when viewed under a microscope. These cancers can occur in various places in the body, including the skin, lungs, kidney, breast, gastrointestinal tract, bone, and muscle.
C27092	Small_Cell_Carcinoma_Fusiform_Cell_Type	Grade_III_Neuroendocrine_Carcinoma	Small Cell Carcinoma, Fusiform Cell Type
C27093	Stage_0_Squamous_Cell_Carcinoma	Carcinoma_in_situ|Grade_III_Intraepithelial_Neoplasia|High-Grade_Squamous_Intraepithelial_Neoplasia|Squamous_Cell_Carcinoma	Stage 0 Squamous Cell Carcinoma|Epidermoid Carcinoma in situ|Epidermoid Cell Carcinoma in situ|Grade 3 SIN|Grade 3 Squamous Intraepithelial Neoplasia|Grade III SIN|Grade III Squamous Intraepithelial Neoplasia|Intraepithelial Squamous Cell Carcinoma|Squamous Carcinoma in situ|Squamous Cell Carcinoma in situ
C27094	Cylindroma	Benign_Eccrine_Neoplasm	Cylindroma|Cylindroma of Skin|Cylindroma of the Skin|Dermal Cylindroma
C27095	Nonpigmented_Nevus	Melanocytic_Nevus	Nonpigmented Nevus
C27096	Undifferentiated_Embryonal_Sarcoma	Hepatic_Sarcoma|Primary_Malignant_Neoplasm_of_Liver|Sarcoma_Differentiation_Score_3	Undifferentiated (Embryonal) Sarcoma|Embryonal Sarcoma|Undifferentiated Sarcoma	Embryonal sarcoma is a rare malignant tumor of the liver, the incidence of which is highest in children between 6 and 10 years of age.
C27097	Anaplastic_Variant_of_Spermatocytic_Seminoma	Retired_Concepts	Anaplastic Variant of Spermatocytic Seminoma
C27098	Hodgkin_s_Disease_Nodular_Sclerosis_Mixed_Cellularity	Hodgkin_s_Lymphoma_Antiquated	Hodgkin's Disease, Nodular Sclerosis, Mixed Cellularity
C27099	Malignant_Lymphoma_Histiocytic_Diffuse	Diffuse_Malignant_Lymphoma|Malignant_Lymphoma_Large_Cell_Type	Malignant Lymphoma, Histiocytic, Diffuse
C27100	Actinomycotic_Cerebral_Abscess	Cerebral_Abscess	Actinomycotic Cerebral Abscess
C27101	Cognitive_Disturbance	Cognitive_Dysfunction	Cognitive Disturbance
C27102	Nasal_Cavity_Disorder	Nasal_Cavity_and_Paranasal_Sinus_Disorder	Nasal Cavity Disorder|Nasal Cavity Disease
C27103	Localized_Pulmonary_Fibrosis	Pulmonary_Fibrosis	Localized Pulmonary Fibrosis
C27104	Radiation-Induced_Damage_to_Artery	Radiation-Induced_Vascular_Disease	Radiation-Induced Damage to Artery
C27105	Eosinophilic_Esophagitis	Esophagitis	Eosinophilic Esophagitis
C27106	Bacterial_Esophagitis	Esophagitis	Bacterial Esophagitis
C27107	Fungal_Esophagitis	Esophagitis|Fungal_Infection|Gastrointestinal_Infection	Fungal Esophagitis
C27108	Viral_Esophagitis	Esophagitis|Gastrointestinal_Infection|Viral_Infection	Viral Esophagitis
C27109	Radiation-Induced_Esophageal_Stricture	Esophageal_Disorder|Non-Neoplastic_Gastrointestinal_Disorder|Radiation-Induced_Abnormalities	Radiation-Induced Esophageal Stricture|Radiation-Induced Stricture of Esophagus
C27110	Colitis_of_Indeterminate_Type	Inflammatory_Bowel_Disease	Colitis of Indeterminate Type
C27111	Radiation_Colitis	Radiation_Enteritis	Radiation Colitis
C27112	Congenital_Thyroid_Aplasia	Congenital_Thyroid_Disorder	Congenital Thyroid Gland Aplasia|Congenital Thyroid Aplasia
C27113	Congenital_Thyroid_Hypoplasia	Congenital_Thyroid_Disorder	Congenital Thyroid Gland Hypoplasia|Congenital Thyroid Hypoplasia
C27114	Congenital_Hypothyroidism_with_Ectopic_Thyroid	Congenital_Hypothyroidism	Congenital Hypothyroidism with Ectopic Thyroid
C27115	Thyroid_Gland_Abscess	Abscess|Non-Neoplastic_Thyroid_Gland_Disorder	Thyroid Gland Abscess
C27116	Congenital_Iodine_Deficiency_Hypothyroidism	Congenital_Hypothyroidism	Congenital Iodine Deficiency Hypothyroidism
C27117	Pituitary_Infarction	Non-Neoplastic_Pituitary_Gland_Disorder	Pituitary Gland Infarction|Pituitary Infarction
C27118	Pituitary_Hemorrhage	Hemorrhage	Pituitary Hemorrhage
C27119	Pituitary_Gland_Cyst	Central_Nervous_System_Cyst	Pituitary Gland Cyst
C27120	Electrolyte_Disorder	Metabolic_Disorder	Electrolyte Disorder
C27121	Helicobacter_Pylori-Associated_Gastritis	Gastritis	Helicobacter Pylori-Associated Gastritis|Helicobacter Gastritis
C27122	Endemic_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma	Endemic Burkitt's Lymphoma|African Burkitt Lymphoma|African Burkitt's Lymphoma|Endemic Burkitt Lymphoma
C27123	Blurred_Vision	Visual_Manifestations	Blurred Vision	Blurred vision is the loss of visual acuity (sharpness of vision) resulting in a loss of ability to see small details. (from MedlinePlus Medical Encyclopedia)
C27124	Congenital_Phimosis	Phimosis	Congenital Phimosis
C27125	Pilar_Tumor	Benign_Outer_Hair_Sheath_and_Infundibulum_Neoplasm	Proliferating Pilar Tumor|Pilar Tumor|Proliferating Trichilemmal Cyst|Proliferating Trichilemmal Tumor
C27126	Multiple_Pigmented_Terminal_Hair_Cysts	Skin_Cyst	Multiple Pigmented Terminal Hair Cysts
C27127	Benign_Cutaneous_Vascular_Neoplasm	Benign_Dermal_Neoplasm|Benign_Vascular_Neoplasm|Cutaneous_Vascular_Neoplasm	Benign Cutaneous Vascular Neoplasm|Benign Cutaneous Vascular Tumor|Benign Skin Vascular Neoplasm|Benign Skin Vascular Tumor
C27128	Adrenal_Gland_Injury	Abdominal_Injury	Adrenal Gland Injury
C27129	Acetabulum_Fracture	Fracture	Acetabulum Fracture
C27130	Ilium_Fracture	Fracture	Ilium Fracture
C27131	Early_Gastric_Cancer	Gastric_Adenocarcinoma	Early Gastric Cancer|EGC|Microinvasive Gastric Cancer|Superficial Gastric Cancer|Superficial Spreading Gastric Cancer|Surface Gastric Cancer	Recently defined by Japanese researchers as a superficial carcinoma confined to the mucosa, or mucosa and submucosa, of the gastric wall.  The regional lymph nodes may or may not be involved.  Most cases occur in the distal third of the stomach.  The 5-year survival following resection is between 80% and 95%, and remains high even when lymph node metastases are present.  -- 2003
C27132	Trichogenic_Trichoblastoma	Benign_Mixed_Epithelial_and_Mesenchymal_Hair_Follicle_Neoplasm	Trichoblastoma|Trichogenic Adnexal Tumor
C27133	Prostate_Endometrioid_Carcinoma	Retired_Concepts	Prostate Endometrioid Carcinoma|Endometrioid Adenocarcinoma of Prostate|Endometrioid Adenocarcinoma of the Prostate|Endometrioid Carcinoma of Prostate|Endometrioid Carcinoma of the Prostate|Prostate Endometrioid Adenocarcinoma|Prostatic Endometrioid Carcinoma
C27134	Hematopoietic_Cell_Neoplasm	Hematologic_Disorder|Hematopoietic_System_Neoplasm|Neoplasm_by_Morphology	Hematopoietic and Lymphoid Cell Neoplasm|Hematologic Cancer|Hematologic Malignancy|Hematologic Neoplasm|Hematological Neoplasm|Hematological Tumor|Hematological Tumors|Hematopoietic Cancer|Hematopoietic Cell Tumor|Hematopoietic Neoplasm|Hematopoietic Neoplasms|Hematopoietic Neoplasms including Lymphomas|Hematopoietic Tumor|Hematopoietic Tumors|Hematopoietic and Lymphoid Neoplasms|Hematopoietic, Including Myeloma|Malignant Hematologic Neoplasm|Malignant Hematopoietic Neoplasm|hematologic malignancies	Cancers of the blood or bone marrow, including leukemia and lymphoma. Also called hematologic cancers.
C27135	Suppurative_Lymphadenitis	Lymphadenitis	Suppurative Lymphadenitis
C27136	Placental_Necrosis	Placental_Non-Neoplastic_Disorder	Placental Necrosis
C27137	Radiation-Induced_Stomatitis	Radiation-Induced_Abnormalities|Stomatitis	Radiation-Induced Stomatitis
C27138	Peritoneal_Hemorrhage	Peritoneal_and_Retroperitoneal_Hemorrhage	Peritoneal Hemorrhage
C27139	Pyogenic_Arthritis	Arthritis	Pyogenic Arthritis
C27140	Ventricular_Aneurysm	Aneurysm	Ventricular Aneurysm
C27141	Immunoglobulin_Heavy_Chain_Deletion	Deficiency_of_Humoral_Immunity	Immunoglobulin Heavy Chain Deletion
C27142	Selective_IgG_Immunodeficiency	Selective_Immunoglobulin_Isotype_Deficiency	Selective IgG Immunodeficiency
C27143	Selective_IgE_Immunodeficiency	Selective_Immunoglobulin_Isotype_Deficiency	Selective IgE Immunodeficiency
C27144	Selective_IgD_Immunodeficiency	Selective_Immunoglobulin_Isotype_Deficiency	Selective IgD Immunodeficiency
C27145	T-Cell_Immunodeficiency	Immunodeficiency_Syndrome	T-Cell Immunodeficiency
C27146	Hemophilia_A	Hemophilia	Hemophilia A|Factor VIII Deficiency	An inherited deficiency of coagulation Factor VIII characterized by the tendency to spontaneous or exaggerated post-traumatic hemorrhage. Inherited as an x-linked recessive disease, hemophilia A is the most common hemophilia, occurring in approximately 1 in 10,000 male births. --2004
C27147	Lymphocytic_Colitis	Microscopic_Colitis	Lymphocytic Colitis
C27148	Ureter_Disorder	Urinary_Tract_Disorder	Ureter Disorder|Ureter Disease|Ureteric Disease|Ureteric Disorder
C27149	Aquired_Phimosis	Phimosis	Aquired Phimosis
C27150	Adrenal_Cortical_Insufficiency	Adrenal_Gland_Insufficiency	Adrenal Cortical Insufficiency
C27151	Irritant_Contact_Dermatitis	Contact_Dermatitis	Irritant Contact Dermatitis
C27152	Sebaceous_Hyperplasia	Benign_Sebaceous_Neoplasm	Sebaceous Hyperplasia
C27153	Lupus_Erythematosus	Autoimmune_Disease|Rheumatologic_Disorder	Lupus Erythematosus|Lupus|lupus	A chronic inflammatory connective tissue disease marked by skin rashes, joint pain and swelling, inflammation of the kidneys, inflammation of the fibrous tissue surrounding the heart (i.e., the pericardium), as well as other problems.  Not all affected individuals display all of these problems.  Also called systemic lupus erythematosus.
C27154	Lumbar_Disc_Degenerative_Disorder	Vertebral_Disc_Degenerative_Disorder	Lumbar Disc Degenerative Disorder|Lumbar Disc Degeneration|Lumbar Disc Degenerative Disease
C27155	Thoracic_Disc_Degenerative_Disorder	Vertebral_Disc_Degenerative_Disorder	Thoracic Disc Degenerative Disorder|Thoracic Disc Degeneration|Thoracic Disc Degenerative Disease
C27156	Cervical_Disc_Degenerative_Disorder	Vertebral_Disc_Degenerative_Disorder	Cervical Disc Degenerative Disorder|Cervical Disc Degeneration|Cervical Disc Degenerative Disease
C27157	Mouth_Sore	Non-Neoplastic_Oral_Cavity_Disorder	Mouth Sore
C27158	Supraventricular_Arrhythmia	Arrhythmia	Supraventricular Arrhythmia	An arrhythmia originating from centers proximal to the ventricles, namely in the atrium, A-V node, or A-V junction, in contrast to arrhythmias arising in the ventricles themselves. -- 2003
C27159	Gingival_Ecchymosis	Ecchymosis|Head_and_Neck_Finding	Gingival Ecchymosis
C27160	Injury_of_Inner_Ear	Ear_Injury	Injury of Inner Ear
C27161	Hand_Fracture	Upper_Extremity_Fracture	Hand Fracture
C27162	Non-Specific_Granulomatous_Orchitis	Testicular_Non-Neoplastic_Disorder	Non-Specific Granulomatous Orchitis
C27163	Arthritis_or_Polyarthritis_due_to_Staphylococcus	Bacterial_Arthritis	Arthritis or Polyarthritis due to Staphylococcus
C27164	Epiphyseal_Fracture	Fracture	Epiphyseal Fracture
C27165	Respiratory_Distress	Ventilation_or_Perfusion_Signs_and_Symptoms	Respiratory Distress
C27166	Inner_Ear_Disorder	Ear_Disorder	Inner Ear Disorder
C27167	Primary_Biliary_Cirrhosis	Cirrhosis	Primary Biliary Cirrhosis|Chronic Non-Suppurative Destructive Cholangitis	a form of biliary cirrhosis in which small intrahepatic ducts are destroyed while the major intra and extra hepatic ducts remain patent; most patients are middle aged females and have circulating antimitochondrial antibodies.
C27168	Obstructive_Sleep_Apnea_Syndrome	Sleep_Apnea	Obstructive Sleep Apnea Syndrome
C27169	Central_Sleep_Apnea_Syndrome	Sleep_Apnea	Central Sleep Apnea Syndrome
C27170	Compression_Fracture	Fracture	Compression Fracture
C27171	Systemic_Lupus_Erythematosus_Rash	Cutaneous_Lupus_Erythematosus|Systemic_Lupus_Erythematosus	Systemic Lupus Erythematosus Rash
C27172	Neonatal_Apneic_Attack	Apnea	Neonatal Apneic Attack
C27174	Stress_Polycythemia	Secondary_Polycythemia	Stress Polycythemia
C27175	Injection_Site_Thrombophlebitis	Thrombophlebitis	Injection Site Thrombophlebitis
C27176	Accelerated_Neoplasm_Growth	Neoplastic_Growth_or_Spread	Accelerated Neoplasm Growth	Neoplasm that is growing at a faster rate
C27177	Palmar-Plantar_Erythodysthesia	Side_Effect	Palmar-Plantar Erythodysthesia|Hand-Foot Syndrome|hand-foot syndrome|palmar-plantar erythrodysthesia	A condition marked by pain, swelling, numbness, tingling, or redness of the hands or feet. It sometimes occurs as a side effect of certain anticancer drugs. Also known as hand-foot syndrome.
C27178	Secondary_Polycythemia	Polycythemia_Excluding_Polycythemia_Vera	Secondary Polycythemia
C27179	Juvenile_Rheumatoid_Arthritis	Rheumatoid_Arthritis	Juvenile Rheumatoid Arthritis
C27180	Radiation-Induced_Fibrous_Mediastinitis	Radiation-Induced_Abnormalities	Radiation-Induced Fibrous Mediastinitis
C27181	Placental_Infarction	Placental_Non-Neoplastic_Disorder	Placental Infarction
C27182	Morphea-Type_Sclerosing_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma	Morphea-Type (Sclerosing) Basal Cell Carcinoma|Basal Cell Carcinoma Sclerosing Type|Morphea-Type Basal Cell Carcinoma|Morpheaform Basal Cell Carcinoma|Sclerosing Type Basal Cell Carcinoma
C27183	Adult_Spinal_Cord_Glioblastoma	Adult_Glioblastoma	Adult Spinal Cord Glioblastoma|Adult Spinal Cord Glioblastoma Multiforme	A rare spinal tumor which is highly malignant and tends to be locally invasive of surrounding neural tissue.  The tumor also tends to spread throughout the neuroaxis and is often rapidly progressive.  Histologically the tumors are highly cellular with nuclear and cellular pleomorphism, endothelial proliferation, mitotic figures, and, often, necrosis. This tumor has a relatively poor prognosis.  Clinical features may include pain followed by rapidly progressive neurologic deficits such as extremity weakness, sensory changes, spasticity, and incontinence. (From Innocenzi et al., Clin Neurol Neurosurg 1997 Feb;99(1):1-5)
C27184	Viral_Gastritis	Gastritis	Viral Gastritis
C27185	Disseminated_Adenocarcinoma	Disseminated_Carcinoma|Metastatic_Adenocarcinoma	Disseminated Adenocarcinoma
C27186	Clinical_Finding	Retired_Concepts	Clinical Finding
C27187	Inherited_Neuropathy	Neuropathy	Inherited Neuropathy
C27188	Radiation-Induced_Mosaicism	Radiation-Induced_Abnormalities	Radiation-Induced Mosaicism
C27189	Interstitial_Cystitis	Chronic_Cystitis	Interstitial Cystitis
C27190	Elbow_Fracture	Upper_Extremity_Fracture	Elbow Fracture
C27191	Hashimoto_s_Thyroiditis	Autoimmune_Disease|Lymphocytic_Thyroiditis	Hashimoto's Thyroiditis|Autoimmune Thyroiditis
C27192	Regional_Enteritis	Enteritis	Regional Enteritis|regional enteritis	Inflammation of the intestines, but usually only of the small intestine.  Regional enteritis increases the risk for developing colon cancer.  Also called Crohn's disease.
C27193	Ear_Infection	Infectious_Disorder_by_Site|Non-Neoplastic_Ear_Disorder	Ear Infection
C27194	Brachial_Plexopathy	Plexopathy	Brachial Plexopathy|brachial plexopathy	(BRAY-kee-ul pleks-AH-pah-thee) A condition marked by numbness, tingling, pain, weakness, or limited movement in the arm or hand. It is caused by an impairment of the brachial plexus, a network of nerves that affect the arm and hand.
C27195	Acne	Dermatitis	Acne|acne	A disorder of the skin marked by inflammation of oil glands and hair glands.
C27196	Lupus_Encephalitis	Systemic_Lupus_Erythematosus	Lupus Encephalitis
C27197	Acute_Pneumonia	Pneumonia	Acute Pneumonia
C27198	Ruptured_Aortic_Aneurysm	Aortic_Aneurysm|Ruptured_Aneurysm	Ruptured Aortic Aneurysm
C27199	Cerebritis	Central_Nervous_System_Infectious_Disorder	Cerebritis
C27200	Gastric_Leiomyosarcoma	Leiomyosarcoma|Malignant_Gastric_Mesenchymal_Neoplasm	Gastric Leiomyosarcoma
C27201	Knee_Fracture	Lower_Extremity_Fracture	Knee Fracture
C27202	Invasive_Papillary_Urothelial_Carcinoma	Invasive_Urothelial_Transitional_Cell_Carcinoma|Papillary_Urothelial_Carcinoma	Infiltrating Bladder Urothelial Carcinoma, Micropapillary Variant	An infiltrating bladder transitional cell carcinoma exhibiting micropapillary growth pattern. -- 2003
C27203	Bacterial_Prostatitis	Bacterial_Infection|Prostatitis	Bacterial Prostatitis
C27204	Rheumatologic_Disorder	Immune_System_Disorder	Rheumatologic Disorder|Collagen Disease|collagen disease	A term previously used to describe chronic diseases of the connective tissue (e.g., rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis), but now is thought to be more appropriate for diseases associated with defects in collagen, which is a component of the connective tissue.
C27205	Vertebral_Disc_Degenerative_Disorder	Spinal_Degenerative_Disorder	Vertebral Disc Degenerative Disorder|Vertebral Disc Degenerative Disease
C27206	Atrophic_Arthritis	Arthritis	Atrophic Arthritis
C27207	Vestibulocochlear_Nerve_Disorder	Cranial_Nerve_Disorder	Vestibulocochlear Nerve Disorder|Acoustic Nerve Disorder|Cochlear Nerve Disorder
C27208	Brain_Aneurysm	Intracranial_Aneurysm	Brain Aneurysm
C27209	Radiation-Related_Malignant_Neoplasm	Radiation-Related_Neoplasm	Radiation-Related Malignant Neoplasm|Radiation-Induced Cancer|Radiation-Induced Malignant Neoplasm|Radiation-Related Cancer
C27210	Olfactory_Nerve_Disorder	Cranial_Nerve_Disorder	Olfactory Nerve Disorder|Disorder of 1st Nerve|Disorder of the 1st Nerve
C27211	Glossopharyngeal_Nerve_Disorder	Cranial_Nerve_Disorder	Glossopharyngeal Nerve Disorder|IX Nerve Disorder|Ninth Nerve Disorder
C27212	Glossopharyngeal_Motor_Neuropathy	Peripheral_Motor_Neuropathy	Glossopharyngeal Motor Neuropathy
C27213	t_14_18_q32_q21	Chromosomal_Translocation	t(14;18)(q32;q21)
C27214	t_11_22_q24_q12_EWS-FLI1	Chromosomal_Translocation	t(11;22)(q24;q12)|t(11;22)(q24;q12)(EWS/FLI-1)
C27215	Coagulation_Factor_Deficiency	Coagulation_Disorder|Genetic_Disorder	Coagulation Factor Deficiency
C27216	Diffuse_Pulmonary_Fibrosis	Pulmonary_Fibrosis	Diffuse Pulmonary Fibrosis
C27217	Cytomegalovirus-Related_Gastritis	Viral_Gastritis	Cytomegalovirus-Related Gastritis|CMV Gastritis|CMV-Related Gastritis|Cytomegalovirus Gastritis
C27218	Cytomegalovirus_Esophagitis	Viral_Esophagitis	Cytomegalovirus Esophagitis|CMV Esophagitis
C27219	Viral_Respiratory_Tract_Infection	Pneumonia|Viral_Infection	Viral Respiratory Tract Infection
C27220	Bone_Infarction	Non-Neoplastic_Bone_Disorder	Bone Infarction
C27221	Entrapment_Neuropathy	Neuropathy	Entrapment Neuropathy
C27222	Cerebral_Aneurysm	Aneurysm	Cerebral Aneurysm
C27223	Infection-Related_Malignant_Neoplasm	Infection-Related_Neoplasm	Infection-Related Malignant Neoplasm|Infection Related Cancer|Infection Related Malignancy|Infection-Related Cancer|Infection-Related Malignancy
C27224	Infection-Related_Neoplasm	Neoplasm_by_Cause	Infection-Related Neoplasm
C27225	Environment-Related_Neoplasm	Neoplasm_by_Cause	Environment-Related Neoplasm
C27226	Testicular_Feminization_Syndrome	Feminization	Testicular Feminization Syndrome	aspects of female morphology in a XY genotype.
C27227	Neonatal_Leukopenia	Non-Neoplastic_Hematologic_Disorder	Neonatal Leukopenia
C27228	Gonadal_Agenesis	Non-Neoplastic_Endocrine_Disorder|Non-Neoplastic_Gonadal_Disorder	Gonadal Agenesis
C27229	Radiation_Induced_DNA_Damage_Retired	Retired_Concepts	Radiation Induced DNA Damage|Genotoxicity, Radiation Induced|Radiation-Induced DNA Damage	Damage to DNA caused by ionizing radiation.  Can cause base change mutations or strand breakage.
C27230	Respiratory_Thoracic_and_Mediastinal_Neoplasm	Retired_Concepts	Respiratory, Thoracic, and Mediastinal Neoplasm|Respiratory, Thoracic, and Mediastinal Tumor
C27231	Cardiovascular_Manifestation	Cardiovascular_System_Signs_and_Symptoms	Cardiovascular Manifestation	Patient complaints (symptoms), physical/laboratory findings(signs) related to the cardiovascular system.
C27232	Blood_Test_Result	Retired_Concepts	Blood Test Result	The result of a chemical, immunologic, or hematologic test performed on a peripheral blood sample.
C27233	Transplant-Related_Disorder	Immunodeficiency-Related_Disorder	Transplant-Related Disorder
C27234	Nipple_Duct_Carcinoma	Nipple_Carcinoma	Nipple Duct Carcinoma
C27235	Gastric_Non-Hodgkin_s_Lymphoma	Gastric_Lymphoma|Gastrointestinal_Non-Hodgkin_s_Lymphoma	Gastric Non-Hodgkin's Lymphoma|Non-Hodgkin's Lymphoma of Stomach|Non-Hodgkin's Lymphoma of the Stomach|Primary Gastric Non-Hodgkin's Lymphoma
C27236	Tobacco-Related_Carcinoma	Carcinoma|Neoplasm_by_Cause|Tobacco_Use_Disorder	Tobacco-Related Carcinoma
C27237	Familial_Adenomatous_Polyposis_Associated_Medulloblastomas	Medulloblastoma	Familial Adenomatous Polyposis Associated Medulloblastoma|FAP Associated Medulloblastoma
C27238	Low-Grade_Anal_Canal_Intraepithelial_Neoplasia	Anal_Canal_Intraepithelial_Neoplasia|Low_Grade_Intraepithelial_Neoplasia	Low Grade Anal Canal Intraepithelial Neoplasia|Low-Grade Intraepithelial Neoplasia of Anal Canal|Low-Grade Intraepithelial Neoplasia of the Anal Canal
C27239	Low_Risk_Gastric_Gastrointestinal_Stromal_Tumor	Gastric_Gastrointestinal_Stromal_Tumor|Low_Risk_Gastrointestinal_Stromal_Tumor	Low Risk Gastric Gastrointestinal Stromal Tumor|Low Risk Gastric GIST
C27240	High_Risk_Gastric_Gastrointestinal_Stromal_Tumor	Gastric_Gastrointestinal_Stromal_Tumor|High_Risk_Gastrointestinal_Stromal_Tumor	High Risk Gastric Gastrointestinal Stromal Tumor|High Risk Gastric GIST
C27241	Adult_Yolk_Sac_Tumor	Adult_Central_Nervous_System_Germ_Cell_Neoplasm|Yolk_Sac_Tumor	Adult Yolk Sac Tumor|Adult Endodermal Sinus Neoplasm|Adult Endodermal Sinus Tumor|Adult Yolk Sac Neoplasm
C27242	Low_Risk_Gastrointestinal_Stromal_Tumor	Gastrointestinal_Stromal_Tumor	Low Risk Gastrointestinal Stromal Tumor|LR GIST|Low Risk GIST
C27243	High_Risk_Gastrointestinal_Stromal_Tumor	Gastrointestinal_Stromal_Tumor	High Risk Gastrointestinal Stromal Tumor|HR GIST|High Risk GIST
C27244	Low_Risk_Small_Intestinal_Gastrointestinal_Stromal_Tumor	Low_Risk_Gastrointestinal_Stromal_Tumor|Small_Intestinal_Gastrointestinal_Stromal_Tumor	Low Risk Small Intestinal Gastrointestinal Stromal Tumor|Low Risk Small Intestinal GIST
C27245	High_Risk_Small_Intestinal_Gastrointestinal_Stromal_Tumor	High_Risk_Gastrointestinal_Stromal_Tumor|Small_Intestinal_Gastrointestinal_Stromal_Tumor	High Risk Small Intestinal Gastrointestinal Stromal Tumor|High Risk Small Intestinal GIST
C27246	Uterine_Corpus_Choriocarcinoma	Choriocarcinoma|Malignant_Uterine_Corpus_Neoplasm	Uterine Corpus Choriocarcinoma
C27247	Stage_IVB_Vulvar_Cancer	Stage_IV_Vulvar_Cancer	Stage IVB Vulvar Cancer|Metastatic Cancer of Vulva|Metastatic Cancer of the Vulva|Metastatic Vulvar Cancer|Metastatic Vulvar Carcinoma|Stage IVB Carcinoma of Vulva|Stage IVB Carcinoma of the Vulva|Stage IVB Vulva Carcinoma|Stage IVB Vulval Cancer|Stage IVB Vulval Carcinoma|Stage IVB Vulvar Carcinoma	Cancer has spread beyond the urethra, vagina, and anus into the lining of the bladder (the sac that holds urine) and the bowel (intestine); or it may have spread to the lymph nodes in the pelvis or to other parts of the body.
C27248	Cranial_Nodular_Fasciitis	Nodular_Fasciitis	Cranial Nodular Fasciitis|Cranial Pseudosarcomatous Fasciitis
C27249	Non-Hodgkin_s_Lymphoma_Lymphoblastic_WF	Lymphoma_by_Working_Formulation_Antiquated	Non-Hodgkin's Lymphoma, Lymphoblastic (WF)
C27250	Uterine_Corpus_Adenomatoid_Tumor	Adenomatoid_Tumor|Benign_Uterine_Corpus_Neoplasm	Uterine Corpus Adenomatoid Tumor|Uterine Corpus Localized Epithelial Mesothelioma
C27251	PDQ_Antiquated_Neoplastic_Concept	Retired_Concepts	PDQ Antiquated Neoplastic Concept
C27252	Enterochromaffin-Like_Cell_Carcinoid_Tumor	Gastrointestinal_Carcinoid_Tumor	Enterochromaffin-Like Cell Carcinoid Tumor
C27253	Metanephric_Adenoma	Benign_Renal_Neoplasm|Renal_Adenoma	Metanephric Adenoma	A benign, well-circumscribed renal cortical neoplasm affecting females more often than males.  Polycythemia has been reported in as many as 12% of patients. -- 2003
C27254	Eccrine_Papillary_Adenocarcinoma	Eccrine_Adenocarcinoma|Papillary_Carcinoma	Papillary Eccrine Carcinoma
C27255	Eccrine_Adenocarcinoma	Malignant_Eccrine_Neoplasm|Sweat_Gland_Carcinoma	Eccrine Carcinoma
C27256	Giant_Cell_Angiofibroma	Angiofibroma	Giant Cell Angiofibroma
C27257	Cellular_Angiofibroma	Angiofibroma	Cellular Angiofibroma
C27258	Malignant_Lymphoma_Non-Cleaved_Cell_Type	Malignant_Lymphoma_by_Cell_Type_Working_Formulation	Malignant Lymphoma, Non-Cleaved Cell Type
C27259	Malignant_Non-Hodgkin_s_Lymphoma_Diffuse_Lymphocytic_Poorly_Differentiated	Diffuse_Malignant_Lymphoma	Malignant Non-Hodgkin's Lymphoma, Diffuse, Lymphocytic, Poorly Differentiated
C27260	Dendritic_Cell_Sarcoma_Not_Otherwise_Specified	Histiocytic_and_Dendritic_Cell_Neoplasms	Dendritic Cell Sarcoma, not Otherwise Specified|Dendritic Cell Sarcoma, NOS	A dendritic cell neoplasm that does not fall into well-defined categories.  Such tumors have been called indeterminate cell sarcomas.  (WHO, 2001) -- 2003
C27261	Pre_T-ALL	Leukemia_Antiquated	Pre T-ALL
C27262	Myelodysplastic_Myeloproliferative_Disease	Myeloid_Neoplasm	Myelodysplastic/Myeloproliferative Disease|MDS-MPD|MDS/MPD|MPD-MDS|MPD/MDS|Myelodysplastic/Myeloproliferative Diseases|Myelodysplastic/Myeloproliferative Disorder|Myelodysplastic/Myeloproliferative Disorders|Myeloproliferative/Myelodysplastic Disorders|Myeloproliferative/Myelodysplastic Syndromes	A category of clonal myeloid disorders that have both myelodysplastic and chronic myeloproliferative features at the time of initial presentation.  (WHO, 2001) -- 2003
C27263	Spindle_Cell_Neoplasm	Neoplasm_by_Morphology	Spindle Cell Neoplasm|Spindle Cell Tumor
C27264	Familial_Atypical_Mole_Melanoma_Syndrome	Hereditary_Neoplastic_Syndrome	Familial Atypical Mole Melanoma Syndrome|FAMM Syndrome
C27265	Malignant_Lymphoma_Large_Cell_Cleaved	Malignant_Non-Hodgkin_s_Lymphoma_Cleaved_Cell	Malignant Lymphoma, Large Cell, Cleaved	Antiquated term describing non-Hodgkin's lymphomas that are usually diffuse and are composed of large cells with irregular nuclei, invisible nucleoli and a small amount of cytoplasm.  This morphologic category includes both mature B- and mature T-cell lymphomas.--2004
C27266	Malignant_Lymphoma_Non-Cleaved_Diffuse	Diffuse_Malignant_Lymphoma|Malignant_Lymphoma_Non-Cleaved_Cell_Type	Malignant Lymphoma, Non-Cleaved, Diffuse	Antiquated term for diffuse non-Hodgkin's lymphomas composed of non-cleaved cells.  The vast majority of cases are mature B-cell lymphomas (Burkitts or diffuse large B-cell lymphomas).--2004
C27267	Lymphoma_Leukemia_by_Kiel_Classification_Antiquated	Hematopoietic_and_Lymphoid_Neoplasms_Antiquated	Lymphoma/Leukemia by Kiel Classification (Antiquated)
C27268	Lymphoma_by_Stage	Lymphoma	Lymphoma by Stage
C27269	Glandular_Cell_Intraepithelial_Neoplasia	Glandular_Cell_Neoplasm|Intraepithelial_Neoplasia	Glandular Cell Intraepithelial Neoplasia
C27270	Hodgkin_s_Disease_Nodular_Sclerosis_Lymphocyte_Predominance	Hodgkin_s_Lymphoma_Antiquated	Hodgkin's Disease, Nodular Sclerosis, Lymphocyte Predominance
C27271	Intermediate_Risk_Gastrointestinal_Stromal_Tumor	Gastrointestinal_Stromal_Tumor	Intermediate Risk Gastrointestinal Stromal Tumor|IR GIST|Intermediate Risk GIST
C27272	Malignant_Lymphoma_Large_Cell_Cleaved_and_Non-Cleaved	Malignant_Lymphoma_Large_Cell_Type	Malignant Lymphoma, Large Cell, Cleaved and Non-Cleaved	Antiquated term describing follicular (nodular) or diffuse non-Hodgkin's lymphomas that are composed of a mixture of large cells: large cleaved cells, with irregular nuclei without visible nucleoli; and large non-cleaved cells (centroblasts), having a rounder nucleus with two to three small, peripherally placed nucleoli and a small amount of basophilic cytoplasm.  The follicular variants represent mature B-cell lymphomas, whereas the diffuse variants can be either mature B- or mature T-cell lymphomas. --2004
C27273	Poroma_Acrospiroma	Benign_Sweat_Gland_Neoplasm	Poroma
C27274	Premalignant_Hematologic_Condition	Hematologic_Disorder|Precancerous_Condition_by_Site	Premalignant Hematologic Condition
C27275	High_Grade_Anal_Canal_Intraepithelial_Neoplasia	Anal_Canal_Intraepithelial_Neoplasia	High Grade Anal Canal Intraepithelial Neoplasia
C27276	Increased_Atypical_Lymphocytes	Abnormal_Laboratory_Test	Increased Atypical Lymphocytes
C27277	Arrhythmia_Requiring_Therapy	Cardiovascular_System_Finding	Arrhythmia Requiring Therapy
C27278	L1_Adult_Acute_Lymphoblastic_Leukemia	L1_Acute_Lymphoblastic_Leukemia	L1 Adult Acute Lymphoblastic Leukemia
C27279	Localized_Pheochromocytoma	Pheochromocytoma	Localized Adrenal Gland Pheochromocytoma	A pheochromocytoma that does not invade surrounding tissues and is confined to the adrenal glands. (NCI05)
C27280	Secondary_Myelodysplastic_Syndrome	Myelodysplastic_Syndrome	Secondary Myelodysplastic Syndrome|Secondary MDS
C27281	FAB_L2	Leukemia_Antiquated	FAB L2|L2 Acute Lymphoblastic Leukemia
C27282	Stage_0_AIDS-Related_Anal_Canal_Cancer	AIDS-Related_Anal_Carcinoma|Stage_0_Anal_Canal_Cancer	Stage 0 AIDS-Related Anal Canal Cancer
C27283	Stage_I_AIDS-Related_Anal_Canal_Cancer	AIDS-Related_Anal_Carcinoma|Stage_I_Anal_Canal_Cancer	Stage I AIDS-Related Anal Canal Cancer
C27284	Stage_II_AIDS-Related_Anal_Canal_Cancer	AIDS-Related_Anal_Carcinoma|Stage_II_Anal_Canal_Cancer	Stage II AIDS-Related Anal Canal Cancer
C27285	Stage_III_AIDS-Related_Anal_Canal_Cancer	AIDS-Related_Anal_Carcinoma|Stage_III_Anal_Canal_Cancer	Stage III AIDS-Related Anal Canal Cancer
C27286	Stage_IV_AIDS-Related_Anal_Canal_Cancer	AIDS-Related_Anal_Carcinoma|Stage_IV_Anal_Canal_Cancer	Stage IV AIDS-Related Anal Canal Cancer
C27287	Ovarian_Endometrioid_Adenofibroma	Adenofibroma|Benign_Ovarian_Endometrioid_Tumor	Ovarian Endometrioid Adenofibroma
C27288	Ovarian_Endometrioid_Cystadenofibroma	Cystadenofibroma|Ovarian_Endometrioid_Adenofibroma	Ovarian Endometrioid Cystadenofibroma
C27289	Borderline_Ovarian_Endometrioid_Cystadenofibroma	Borderline_Ovarian_Endometrioid_Adenofibroma|Cystadenofibroma	Borderline Ovarian Endometrioid Cystadenofibroma|Borderline Malignancy Ovarian Endometrioid Cystadenofibroma|Low Malignant Potential Ovarian Endometrioid Cystadenofibroma
C27290	L1_Acute_Lymphoblastic_Leukemia	Leukemia_Antiquated	L1 Acute Lymphoblastic Leukemia
C27291	Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor	Neuroectodermal_Tumor	Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Ewing's Family of Tumors|Ewing's Family of Tumours|Tumors of Ewing's Family|Tumors of the Ewing's Family	A spectrum of malignant tumors, affecting mostly males under age 20, characterized morphologically by the presence of small round cells.  Ewing's sarcoma and peripheral primitive neuroectodermal tumor represent the ends of a spectrum, with Ewing's sarcoma lacking evidence of neural differentiation and the markers that characterize the peripheral primitive neuroectodermal tumor.  Ewing's sarcoma and peripheral primitive neuroectodermal tumor may share cytogenetic abnormalities, proto-oncogene expression, cell culture and immunohistochemical abnormalities.  These tumors may occur in the soft tissues or the bones.  Pain and the presence of a mass are the most common clinical symptoms. -- 2004
C27292	Metastatic_Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor	Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor	Metastatic Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor
C27293	Extraosseous_Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor	Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor	Extraosseous Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor
C27294	Localized_Primitive_Neuroectodermal_Tumor	Neuroectodermal_Tumor	Localized Primitive Neuroectodermal Tumor
C27295	Recurrent_Primitive_Neuroectodermal_Tumor	Neuroectodermal_Tumor	Recurrent Primitive Neuroectodermal Tumor
C27296	Positive_Lymph_Node	Positive_Test_Result	Positive Lymph Node|node-positive	Cancer that has spread to the lymph nodes.
C27297	Hormonal_Change	Endocrine_System_Finding	Hormonal Change
C27298	Ptosis	Congenital_or_Acquired_Anatomic_Abnormality	Ptosis
C27299	Ruptured_Thoracic_Aneurysm	Ruptured_Aortic_Aneurysm|Thoracic_Aortic_Aneurysm	Ruptured Thoracic Aneurysm
C27300	Meckel_s_Diverticulitis	Diverticulitis	Meckel's Diverticulitis
C27301	Axonal_Neuropathy	Neuropathy	Axonal Neuropathy
C27302	Xanthogranuloma	Benign_Fibrohistiocytic_Neoplasm	Xanthogranuloma
C27303	Peritoneal_and_Retroperitoneal_Hemorrhage	Hemorrhage	Peritoneal and Retroperitoneal Hemorrhage
C27304	Congenital_Thyroid_Disorder	Non-Neoplastic_Endocrine_Disorder|Non-Neoplastic_Thyroid_Gland_Disorder	Congenital Thyroid Gland Disorder|Congenital Thyroid Disorder
C27305	Viral_Laryngitis	Laryngitis	Viral Laryngitis
C27306	Staphylococcal_Septic_Arthritis	Arthritis_or_Polyarthritis_due_to_Staphylococcus|Septic_Arthritis	Staphylococcal Septic Arthritis
C27307	Anaplastic_Malignant_Intracranial_Meningioma	Anaplastic_Malignant_Meningioma|Intracranial_Meningioma	Anaplastic (Malignant) Intracranial Meningioma
C27308	Stage_I_B-Cell_Non-Hodgkin_s_Lymphoma	B-Cell_Non-Hodgkin_s_Lymphoma|Stage_I_Non-Hodgkin_s_Lymphoma	Stage I B-Cell Non-Hodgkin's Lymphoma|Stage I B-Cell Lymphoma
C27309	Ethmoid_Fracture	Fracture	Ethmoid Fracture
C27310	Dehydration_Polycythemia	Secondary_Polycythemia	Dehydration Polycythemia
C27311	Physiological_Polycythemia	Polycythemia_Excluding_Polycythemia_Vera	Physiological Polycythemia
C27312	Polycythemia_due_to_Hypoxia	Secondary_Polycythemia	Polycythemia due to Hypoxia
C27313	Adult_Dermatomyositis	Dermatomyositis	Adult Dermatomyositis
C27314	Mycobacterium_Avium_Complex_Lymphadenitis	Lymph_Node_Tuberculosis	Mycobacterium Avium Complex Lymphadenitis|MAC Lymphadenitis
C27315	Mycobacterium_Avium_Intracellulare_Lymphadenitis	Lymph_Node_Tuberculosis	Mycobacterium Avium Intracellulare Lymphadenitis|MAI Lymphadenitis
C27316	Permanent_Spinal_Nerve_Paralysis	Nerve_Paralysis	Permanent Spinal Nerve Paralysis
C27317	Conjunctival_Ecchymosis	Conjunctival_Haemorrhage|Ecchymosis	Conjunctival Ecchymosis
C27318	Dissecting_Thoracic_Aortic_Aneurysm	Dissecting_Aortic_Aneurysm|Thoracic_Aortic_Aneurysm	Dissecting Thoracic Aortic Aneurysm
C27319	Transient_Hypogammaglobulinemia	Hypogammaglobulinemia	Transient Hypogammaglobulinemia
C27320	Blennorrhagic_Arthritis	Bacterial_Arthritis	Blennorrhagic Arthritis
C27321	AIDS-Related_Enterocolitis	Diseases_Associated_with_AIDS	AIDS-Related Enterocolitis
C27322	Periampullary_Adenocarcinoma	Duodenal_Adenocarcinoma	Periampullary Adenocarcinoma
C27323	Resectable_Duodenal_Carcinoma	Duodenal_Carcinoma	Resectable Duodenal Carcinoma
C27324	Non-Resectable_Cholangiocarcinoma	Cholangiocarcinoma	Non-Resectable Cholangiocarcinoma|Non-Resectable Cholangiocellular Carcinoma
C27325	Recurrent_Cholangiocarcinoma	Cholangiocarcinoma	Recurrent Cholangiocarcinoma|Recurrent Cholangiocellular Carcinoma
C27326	Resectable_Cholangiocarcinoma	Cholangiocarcinoma	Resectable Cholangiocarcinoma|Resectable Cholangiocellular Carcinoma
C27327	Stage_I_Centroblastic_Follicular_Lymphoma	Malignant_Lymphoma_Centroblastic_Follicular	Stage I Centroblastic Follicular Lymphoma
C27328	Stage_II_Centroblastic_Follicular_Lymphoma	Malignant_Lymphoma_Centroblastic_Follicular	Stage II Centroblastic Follicular Lymphoma
C27329	Necrotizing_Gastritis	Gastritis	Necrotizing Gastritis
C27330	Injection_Site_Arthritis	Arthritis	Injection Site Arthritis
C27331	Thyroid_Malformation	Non-Neoplastic_Endocrine_Disorder|Non-Neoplastic_Thyroid_Gland_Disorder	Thyroid Gland Malformation|Thyroid Malformation
C27332	Postauricular_Lymphadenitis	Lymphadenitis	Postauricular Lymphadenitis
C27333	Axillary_Lymphadenitis	Lymphadenitis|Non-Neoplastic_Axillary_Disorder	Axillary Lymphadenitis|Axillary Adenitis
C27334	Adrenal_Gland_Abscess	Abscess|Non-Neoplastic_Adrenal_Gland_Disorder	Adrenal Gland Abscess
C27335	Glossopharyngeal_Nerve_Paralysis	Cranial_Nerve_Paralysis|Glossopharyngeal_Nerve_Disorder	Glossopharyngeal Nerve Paralysis
C27336	Lumbar_Vertebral_Fracture_L2	Lumbar_Vertebral_Fracture	Lumbar Vertebral Fracture L2
C27337	Median_Nerve_Paralysis	Non-Neoplastic_Peripheral_Nervous_System_Disorder	Median Nerve Paralysis
C27338	Congenital_Neuropathy	Neuropathy	Congenital Neuropathy
C27339	Inner_Ear_Infection	Non-Neoplastic_Inner_Ear_Disorder|Otitis	Inner Ear Infection
C27340	Bacterial_Gastritis	Gastritis	Bacterial Gastritis
C27341	Herpetic_Gastritis	Viral_Gastritis	Herpetic Gastritis
C27342	Fungal_Gastritis	Gastritis	Fungal Gastritis
C27343	Pituitary_Hypoplasia	Non-Neoplastic_Endocrine_Disorder|Non-Neoplastic_Pituitary_Gland_Disorder	Pituitary Gland Hypoplasia|Pituitary Hypoplasia
C27344	AIDS-Related_Retinopathy	Diseases_Associated_with_AIDS	AIDS-Related Retinopathy
C27345	Non-Resectable_Hepatocellular_Carcinoma	Hepatocellular_Carcinoma	Non-Resectable Hepatocellular Carcinoma
C27346	Parathyroid_Gland_Abscess	Abscess|Non-Neoplastic_Parathyroid_Gland_Disorder	Parathyroid Gland Abscess
C27347	Tuberculous_Abscess	Tuberculosis	Tuberculous Abscess
C27348	Granulomatous_Gastritis	Gastritis	Granulomatous Gastritis
C27349	Histiocytic_Sarcoma	Histiocytic_and_Dendritic_Cell_Neoplasms	Histiocytic Sarcoma
C27350	Chronic_Myeloproliferative_Disease_Unclassifiable	Chronic_Myeloproliferative_Disorder	Chronic Myeloproliferative Disease, Unclassifiable|CMPD, U|CMPD-U|Chronic Myeloproliferative Disorder, Unclassifiable|Unclassifiable Chronic Myeloproliferative Disease|Unclassifiable Chronic Myeloproliferative Disorder	This subgroup of chronic myeloproliferative disorders includes cases which do not meet the morphologic criteria of any of the defined chronic myeloproliferative disorders, or which have characteristics that overlap at least two of the chronic myeloproliferative disorders.
C27351	Immune_System_and_Related_Disorders	Diseases_and_Disorders	Immune System and Related Disorders|Immunodeficiency and Immunosuppression Disorders
C27352	Peripheral_T-Cell_Lymphoma_Large_Cell	Hematopoietic_and_Lymphoid_Neoplasms_Antiquated	Peripheral T-Cell Lymphoma, Large Cell
C27353	Localized_Peripheral_Primitive_Neuroectodermal_Tumor_of_Bone	Localized_Peripheral_Primitive_Neuroectodermal_Tumor|Peripheral_Neuroectodermal_Tumor_of_Bone	Localized Peripheral Primitive Neuroectodermal Tumor of Bone|Localized Neuroepithelioma of Bone|Localized PNET of Bone
C27354	Recurrent_Peripheral_Primitive_Neuroectodermal_Tumor_of_Bone	Peripheral_Neuroectodermal_Tumor_of_Bone|Recurrent_Peripheral_Primitive_Neuroectodermal_Tumor	Recurrent Peripheral Primitive Neuroectodermal Tumor of Bone|Recurrent Neuroepithelioma of Bone|Recurrent PNET of Bone	The reemergence of peripheral neuroepithelioma of bone after a period of remission
C27355	Mixed_Pineocytoma-Pineoblastoma	Retired_Concepts	Mixed Pineocytoma-Pineoblastoma
C27356	Leukemia_Antiquated	Hematopoietic_and_Lymphoid_Neoplasms_Antiquated	Leukemia (Antiquated)
C27357	Refractory_Hematologic_Malignancy	Hematopoietic_Cell_Neoplasm	Refractory Hematologic Malignancy|Refractory Hematologic Cancer
C27358	Relapsed_Hematologic_Malignancy	Hematopoietic_Cell_Neoplasm	Recurrent Hematologic Malignancy|Recurrent Hematologic Cancer|Relapsed Hematologic Cancer|Relapsed Hematologic Malignancy
C27359	Unresectable_Malignant_Neoplasm	Malignant_Neoplasm	Unresectable Malignant Neoplasm|Unresectable Malignant Tumor
C27360	Philadelphia_Chromosome_Negative_BCR-ABL_Positive_Chronic_Myelogenous_Leukemia	Philadelphia_Chromosome_Negative_Chronic_Myelogenous_Leukemia	Philadelphia Chromosome Negative BCR-ABL1 Positive Chronic Myelogenous Leukemia
C27361	Philadelphia_Chromosome_Negative_BCR-ABL_Negative_Chronic_Myelogenous_Leukemia	Leukemia_Antiquated	Philadelphia Chromosome Negative BCR-ABL1 Negative Chronic Myelogenous Leukemia
C27362	Childhood_Ganglioglioma	Childhood_Central_Nervous_System_Neoplasm|Ganglioglioma	Childhood Ganglioglioma
C27363	Adult_Ganglioglioma	Ganglioglioma	Adult Ganglioglioma
C27364	Childhood_Yolk_Sac_Tumor	Malignant_Childhood_Neoplasm|Yolk_Sac_Tumor	Childhood Yolk Sac Tumor|Childhood Endodermal Sinus Neoplasm|Childhood Endodermal Sinus Tumor|Childhood Yolk Sac Neoplasm|Pediatric Endodermal Sinus Neoplasm|Pediatric Yolk Sac Neoplasm|Pediatric Yolk Sac Tumor
C27365	Adult_Primary_Cutaneous_Anaplastic_Large_Cell_Lymphoma	Adult_Anaplastic_Large_Cell_Lymphoma|Primary_Cutaneous_Anaplastic_Large_Cell_Lymphoma	Adult Primary Cutaneous Anaplastic Large Cell Lymphoma|Adult Primary Cutaneous CD30+ Anaplastic Large Cell Lymphoma|Adult Primary Cutaneous K-1+ Anaplastic Large Cell Lymphoma
C27366	Adult_Systemic_Anaplastic_Large_Cell_Lymphoma	Adult_Anaplastic_Large_Cell_Lymphoma|Systemic_Anaplastic_Large_Cell_Lymphoma	Adult Systemic Anaplastic Large Cell Lymphoma|Adult Systemic CD30+ Anaplastic Large Cell Lymphoma|Adult Systemic K-1+ Anaplastic Large Cell Lymphoma
C27367	Adult_Anaplastic_Large_Cell_Lymphoma	Adult_Non-Hodgkin_s_Lymphoma|Anaplastic_Large_Cell_Lymphoma	Adult Anaplastic Large Cell Lymphoma|Adult CD30+ Anaplastic Large Cell Lymphoma|Adult K-1+ Anaplastic Large Cell Lymphoma
C27368	Childhood_Hepatic_Neoplasm	Childhood_Neoplasm|Hepatic_Disorder|Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm	Childhood Hepatic Neoplasm|Childhood Liver Neoplasm
C27369	Adult_Pleomorphic_Rhabdomyosarcoma	Adult_Rhabdomyosarcoma|Pleomorphic_Rhabdomyosarcoma	Adult Anaplastic Rhabdomyosarcoma|Adult Pleomorphic Rhabdomyosarcoma
C27370	Adult_Clear_Cell_Sarcoma_of_Soft_Parts	Adult_Soft_Tissue_Sarcoma|Clear_Cell_Sarcoma_of_Soft_Parts	Adult Clear Cell Sarcoma of Soft Parts	A rare malignant neoplasm with melanocytic differentiation characterized by the presence of polygonal or spindle shaped clear cells affecting young adults. This sarcoma usually affects the tendons and aponeuroses and is associated with a poor prognosis due to recurrences and metastases.
C27371	Childhood_Clear_Cell_Sarcoma_of_Soft_Parts	Childhood_Soft_Tissue_Sarcoma|Clear_Cell_Sarcoma_of_Soft_Parts	Childhood Clear Cell Sarcoma of Soft Parts|Pediatric Clear Cell Sarcoma of Soft Parts	A rare malignant neoplasm with melanocytic differentiation characterized by the presence of polygonal or spindle shaped clear cells affecting children. This sarcoma usually affects the tendons and aponeuroses and is associated with a poor prognosis due to recurrences and metastases.
C27372	Childhood_Desmoplastic_Small_Round_Cell_Tumor	Childhood_Soft_Tissue_Sarcoma|Desmoplastic_Small_Round_Cell_Tumor	Childhood Desmoplastic Small Round Cell Tumor|Pediatric Desmoplastic Small Round Cell Tumor
C27373	Adult_Desmoplastic_Small_Round_Cell_Tumor	Adult_Soft_Tissue_Sarcoma|Desmoplastic_Small_Round_Cell_Tumor	Adult Desmoplastic Small Round Cell Tumor
C27374	Childhood_Mesenchymal_Chondrosarcoma	Childhood_Soft_Tissue_Sarcoma|Mesenchymal_Chondrosarcoma	Childhood Mesenchymal Chondrosarcoma|Pediatric Mesenchymal Chondrosarcoma
C27375	Adult_Mesenchymal_Chondrosarcoma	Adult_Soft_Tissue_Sarcoma|Mesenchymal_Chondrosarcoma	Adult Mesenchymal Chondrosarcoma
C27376	Childhood_Extraskeletal_Osteosarcoma	Childhood_Soft_Tissue_Sarcoma|Extraskeletal_Osteosarcoma	Childhood Extraskeletal Osteosarcoma|Childhood Extraosseous Osteosarcoma|Pediatric Extraosseous Osteosarcoma|Pediatric Extraskeletal Osteosarcoma
C27377	Childhood_Myxoid_Chondrosarcoma	Childhood_Soft_Tissue_Sarcoma|Myxoid_Chondrosarcoma	Childhood Myxoid Chondrosarcoma|Pediatric Myxoid Chondrosarcoma
C27378	Adult_Myxoid_Chondrosarcoma	Adult_Soft_Tissue_Sarcoma|Myxoid_Chondrosarcoma	Adult Myxoid Chondrosarcoma
C27379	Mucin-Secreting_Adenocarcinoma	Adenocarcinoma|Mucin-Secreting_Carcinoma	Mucin-Secreting Adenocarcinoma|Mucin-Producing Adenocarcinoma
C27380	Thyroid_Adenocarcinoma	Adenocarcinoma|Common_Carcinoma|Malignant_Endocrine_Neoplasm|Thyroid_Carcinoma	Thyroid Gland Adenocarcinoma|Thyroid Adenocarcinoma	An adenocarcinoma arising from the follicular cells of the thyroid gland.  According to the degree of differentiation, it is classified either as differentiated carcinoma (extensive evidence of follicular cell differentiation), or poorly differentiated carcinoma (limited evidence of follicular cell differentiation).  (NCI05)
C27381	Metastatic_Carcinoma_to_Adrenal_Cortex	Malignant_Adrenal_Cortex_Neoplasm|Metastatic_Carcinoma|Metastatic_Neoplasm_to_the_Adrenal_Gland	Metastatic Carcinoma to the Adrenal Cortex|Metastatic Carcinoma to Adrenal Cortex	A carcinoma that has spread to the adrenal cortex from an adjacent or distal anatomic site.  (NCI05)
C27382	Abdominal_Carcinomatosis	Carcinomatosis|Metastatic_Neoplasm_to_the_Abdominal_Cavity	Abdominal Carcinomatosis
C27383	Meningeal_Carcinomatosis	Carcinomatosis|Malignant_Neoplasms_of_the_Meninges	Meningeal Carcinomatosis
C27384	Pleural_Carcinomatosis	Carcinomatosis|Metastatic_Neoplasm_to_the_Pleura	Pleural Carcinomatosis
C27385	Pericardial_Carcinomatosis	Carcinomatosis|Metastatic_Neoplasm_to_the_Pericardium	Pericardial Carcinomatosis
C27386	Lymphoepithelioma-Like_Gastric_Carcinoma	Retired_Concepts	Lymphoepithelioma-Like Gastric Carcinoma
C27387	Lymphoepithelioma-Like_Carcinoma	Carcinoma	Lymphoepithelioma-Like Carcinoma
C27388	Sclerosing_Hepatocellular_Carcinoma	Hepatocellular_Carcinoma	Sclerosing Hepatocellular Carcinoma|Sclerosing Hepatic Carcinoma
C27389	Carcinoma_Arising_in_Nasal_Papillomatosis	Nasal_Cavity_Carcinoma	Carcinoma Arising in Nasal Papillomatosis
C27390	Ovarian_Small_Cell_Carcinoma	Ovarian_Carcinoma|Small_Cell_Carcinoma	Ovarian Small Cell Carcinoma
C27391	Metastatic_Ovarian_Small_Cell_Carcinoma_with_Hypercalcemia	Ovarian_Small_Cell_Carcinoma_Hypercalcemic_Type	Metastatic Ovarian Small Cell Carcinoma, Hypercalcemic Type
C27392	Basophil_Adenocarcinoma	Pituitary_Gland_Neoplasm_Antiquated	Pituitary Gland Basophil Carcinoma|Basophil Adenocarcinoma|Basophil Carcinoma
C27393	Parathyroid_Oncocytic_Adenoma	Oxyphilic_Adenoma|Parathyroid_Adenoma	Parathyroid Gland Oncocytic Adenoma|Parathyroid Oncocytic Adenoma	A parathyroid gland adenoma composed predominantly or entirely of neoplastic cells with abundant granular eosinophilic cytoplasm. (NCI05)
C27394	Vaginal_Melanoma	Malignant_Vaginal_Neoplasm|Melanoma	Vaginal Melanoma|Melanoma of Vagina|Melanoma of the Vagina
C27395	Intraosseous_Ameloblastoma	Ameloblastoma	Intraosseous Ameloblastoma
C27396	Extraosseous_Ameloblastoma	Ameloblastoma	Extraosseous Ameloblastoma
C27397	Follicular_Ameloblastoma	Ameloblastoma	Follicular Ameloblastoma
C27398	Granular_Cell_Ameloblastoma	Ameloblastoma	Granular Cell Ameloblastoma
C27399	Adult_Spinal_Cord_Ependymoma	Adult_Ependymoma|Spinal_Cord_Ependymoma	Adult Spinal Cord Ependymoma
C27400	Adult_Central_Nervous_System_Mature_Teratoma	Adult_Central_Nervous_System_Teratoma|Central_Nervous_System_Mature_Teratoma	Adult Central Nervous System Mature Teratoma
C27401	Adult_Central_Nervous_System_Immature_Teratoma	Adult_Central_Nervous_System_Teratoma|Central_Nervous_System_Immature_Teratoma	Adult Central Nervous System Immature Teratoma
C27402	Adult_Central_Nervous_System_Mixed_Germ_Cell_Neoplasm	Adult_Central_Nervous_System_Germ_Cell_Neoplasm|Mixed_Germ_Cell_Neoplasms_of_the_Central_Nervous_System	Adult Central Nervous System Mixed Germ Cell Tumor
C27403	Childhood_Central_Nervous_System_Mixed_Germ_Cell_Neoplasm	Childhood_Central_Nervous_System_Germ_Cell_Neoplasm|Mixed_Germ_Cell_Neoplasms_of_the_Central_Nervous_System	Childhood Central Nervous System Mixed Germ Cell Tumor
C27404	Childhood_Central_Nervous_System_Mature_Teratoma	Central_Nervous_System_Mature_Teratoma|Childhood_Central_Nervous_System_Teratoma	Childhood Central Nervous System Mature Teratoma
C27405	Childhood_Central_Nervous_System_Immature_Teratoma	Central_Nervous_System_Immature_Teratoma|Childhood_Central_Nervous_System_Teratoma	Childhood Central Nervous System Immature Teratoma
C27406	Childhood_Central_Nervous_System_Germinoma	Childhood_Central_Nervous_System_Germ_Cell_Neoplasm|Germinoma_of_the_Central_Nervous_System	Childhood Central Nervous System Germinoma
C27407	Duodenal_Delta_Cell_Somatostatin_Producing_Neoplasm	Small_Intestinal_Delta_Cell_Somatostatin_Producing_Neoplasm	Duodenal Somatostatin Producing Tumor|Duodenal Somatostatin Producing Neoplasm|Duodenal Somatostatinoma
C27408	Metastatic_Carcinoma_to_the_Lung	Metastatic_Carcinoma|Metastatic_Neoplasm_to_the_Lung	Metastatic Carcinoma to the Lung
C27409	Small_Intestinal_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma|Small_Intestinal_Non-Hodgkin_s_Lymphoma	Small Intestinal Burkitt's Lymphoma|Primary Small Intestinal Burkitt's Lymphoma|Small Intestine Burkitt Lymphoma|Small Intestine Burkitt's Lymphoma
C27410	Small_Intestinal_Atypical_Burkitt_s_Burkitt_s-Like_Lymphoma	Atypical_Burkitt_s_Burkitt_s-Like_Lymphoma|Small_Intestinal_Burkitt_s_Lymphoma	Small Intestinal Atypical Burkitt's/Burkitt's-Like Lymphoma|Primary Small Intestinal Atypical Burkitt's/Burkitt's-Like Lymphoma|Small Intestine Atypical Burkitt's/Burkitt's-like Lymphoma
C27411	Colon_Mantle_Cell_Lymphoma	Mantle_Cell_Lymphoma	Colon Mantle Cell Lymphoma
C27412	Ampulla_of_Vater_Tubulovillous_Adenoma	Ampulla_of_Vater_Adenoma|Tubulovillous_Adenoma	Ampulla of Vater Tubulovillous Adenoma
C27413	Adenoma_of_the_Colon_with_Intramucosal_Adenocarcinoma	Colon_Intramucosal_Adenocarcinoma	Adenoma of the Colon with Intramucosal Adenocarcinoma|Adenoma of Colon with Intramucosal Adenocarcinoma|Colonic Adenoma with Intramucosal Adenocarcinoma
C27414	Ampulla_of_Vater_Clear_Cell_Adenocarcinoma	Ampulla_of_Vater_Adenocarcinoma|Clear_Cell_Adenocarcinoma	Ampulla of Vater Clear Cell Adenocarcinoma	A malignant glandular epithelial tumor affecting the ampulla of Vater.  It is composed of glycogen-rich cells with hyperchromatic nuclei.
C27415	Ampulla_of_Vater_Intestinal_Type_Adenocarcinoma	Ampulla_of_Vater_Adenocarcinoma|Intestinal_Type_Adenocarcinoma	Ampulla of Vater Intestinal Type Adenocarcinoma
C27416	Ampulla_of_Vater_Mucinous_Adenocarcinoma	Ampulla_of_Vater_Adenocarcinoma|Mucinous_Adenocarcinoma	Ampulla of Vater Mucinous Adenocarcinoma
C27417	Ampulla_of_Vater_Squamous_Cell_Carcinoma	Ampulla_of_Vater_Carcinoma|Squamous_Cell_Carcinoma	Ampulla of Vater Squamous Cell Carcinoma
C27418	Ampulla_of_Vater_Adenosquamous_Carcinoma	Adenosquamous_Carcinoma|Ampulla_of_Vater_Carcinoma	Ampulla of Vater Adenosquamous Carcinoma
C27419	Ampulla_of_Vater_Undifferentiated_Carcinoma	Ampulla_of_Vater_Carcinoma|Undifferentiated_Carcinoma	Ampulla of Vater Undifferentiated Carcinoma
C27420	Esophageal_Verrucous_Carcinoma	Esophageal_Squamous_Cell_Carcinoma|Verrucous_Carcinoma	Esophageal Verrucous Carcinoma|Verrucous Carcinoma of Esophagus|Verrucous Carcinoma of the Esophagus	A rare variant of esophageal squamous cell carcinoma.  It is an exophytic, cauliflower-like or papillary mass that can arise in any part of the esophagus.  This variant of squamous cell carcinoma grows slowly and invades locally, with a very low metastasizing potential.  (WHO, 2000) -- 2003
C27421	Esophageal_Adenosquamous_Carcinoma	Adenosquamous_Carcinoma|Esophageal_Carcinoma	Esophageal Adenosquamous Carcinoma	A carcinoma that has a significant squamous carcinomatous component that is intermingled with an adenocarcinoma.  (WHO, 2000) -- 2003
C27422	Esophageal_Undifferentiated_Carcinoma	Esophageal_Carcinoma|Undifferentiated_Carcinoma	Esophageal Undifferentiated Carcinoma
C27423	Esophageal_Squamous_Intraepithelial_Neoplasia	Esophageal_Intraepithelial_Neoplasia|Squamous_Cell_Intraepithelial_Neoplasia	Esophageal Squamous Intraepithelial Neoplasia
C27424	Esophageal_Glandular_Intraepithelial_Neoplasia	Esophageal_Intraepithelial_Neoplasia|Glandular_Cell_Intraepithelial_Neoplasia	Esophageal Glandular Intraepithelial Neoplasia
C27425	Esophageal_High-Grade_Intraepithelial_Neoplasia	Esophageal_Intraepithelial_Neoplasia|High_Grade_Intraepithelial_Neoplasia	Esophageal High-Grade Intraepithelial Neoplasia	A lesion in which the architectural and cytologic abnormalities involve both the lower and the upper half of the esophageal mucosa.  It includes lesions termed moderate dysplasia, and carcinoma in situ (severe dysplasia).  (WHO, 2000) -- 2003
C27426	Esophageal_High-Grade_Squamous_Intraepithelial_Neoplasia	Esophageal_High-Grade_Intraepithelial_Neoplasia|Esophageal_Squamous_Intraepithelial_Neoplasia|High-Grade_Squamous_Intraepithelial_Neoplasia	Esophageal High-Grade Squamous Intraepithelial Neoplasia
C27427	Esophageal_Low-Grade_Squamous_Intraepithelial_Neoplasia	Esophageal_Low-Grade_Intraepithelial_Neoplasia|Esophageal_Squamous_Intraepithelial_Neoplasia|Low_Grade_Squamous_Intraepithelial_Neoplasia	Esophageal Low Grade Squamous Intraepithelial Neoplasia
C27428	Esophageal_Low-Grade_Glandular_Intraepithelial_Neoplasia	Esophageal_Glandular_Intraepithelial_Neoplasia|Esophageal_Low-Grade_Intraepithelial_Neoplasia|Low_Grade_Glandular_Intraepithelial_Neoplasia	Esophageal Low Grade Glandular Intraepithelial Neoplasia
C27429	Esophageal_High-Grade_Glandular_Intraepithelial_Neoplasia	Esophageal_Glandular_Intraepithelial_Neoplasia|Esophageal_High-Grade_Intraepithelial_Neoplasia|High_Grade_Glandular_Intraepithelial_Neoplasia	Esophageal High-Grade Glandular Intraepithelial Neoplasia
C27430	Esophageal_Gastrointestinal_Stromal_Tumor	Esophageal_Neoplasm|Gastrointestinal_Stromal_Tumor_of_the_Gastrointestinal_Tract	Esophageal Gastrointestinal Stromal Tumor|Esophageal GIST	Located most frequently in the lower esophagus and begin as intramural lesions.  Predominantly occurs in older males.  Dysphagia is the usual complaint.  Most tumors are clinically malignant, and commonly develop liver metastases.  (WHO, 2000) -- 2003
C27431	Low_Risk_Esophageal_Gastrointestinal_Stromal_Tumor	Esophageal_Gastrointestinal_Stromal_Tumor|Low_Risk_Gastrointestinal_Stromal_Tumor	Low Risk Esophageal Gastrointestinal Stromal Tumor|Low Risk Esophageal GIST
C27432	High_Risk_Esophageal_Gastrointestinal_Stromal_Tumor	Esophageal_Gastrointestinal_Stromal_Tumor|High_Risk_Gastrointestinal_Stromal_Tumor	High Risk Esophageal Gastrointestinal Stromal Tumor|High Risk Esophageal GIST
C27433	Intermediate_Risk_Esophageal_Gastrointestinal_Stromal_Tumor	Esophageal_Gastrointestinal_Stromal_Tumor|Intermediate_Risk_Gastrointestinal_Stromal_Tumor	Intermediate Risk Esophageal Gastrointestinal Stromal Tumor|Intermediate Risk Esophageal GIST
C27434	Intermediate_Risk_Small_Intestinal_Gastrointestinal_Stromal_Tumor	Intermediate_Risk_Gastrointestinal_Stromal_Tumor|Small_Intestinal_Gastrointestinal_Stromal_Tumor	Intermediate Risk Small Intestinal Gastrointestinal Stromal Tumor|Intermediate Risk Small Intestinal GIST
C27435	Intermediate_Risk_Gastric_Gastrointestinal_Stromal_Tumor	Gastric_Gastrointestinal_Stromal_Tumor|Intermediate_Risk_Gastrointestinal_Stromal_Tumor	Intermediate Risk Gastric Gastrointestinal Stromal Tumor|Intermediate Risk Gastric GIST
C27436	Low-Grade_Gastric_Intraepithelial_Neoplasia	Gastric_Intraepithelial_Neoplasia|Low_Grade_Glandular_Intraepithelial_Neoplasia	Low Grade Gastric Intraepithelial Neoplasia|Low-Grade Gastric Glandular Intraepithelial Neoplasia	A lesion also known as mild dysplasia, shows a mildly modified mucosal architecture, including the presence of tubular structures with budding and branching, papillary enfolding, crypt lengthening, and cystic changes.  (WHO, 2000) -- 2003
C27437	High-Grade_Gastric_Intraepithelial_Neoplasia	Gastric_Intraepithelial_Neoplasia|High_Grade_Glandular_Intraepithelial_Neoplasia	High Grade Gastric Intraepithelial Neoplasia|High-Grade Gastric Glandular Intraepithelial Dysplasia|High-Grade Gastric Glandular Intraepithelial Neoplasia|High-Grade Gastric Intraepithelial Dysplasia
C27438	Benign_Gastric_Mesenchymal_Neoplasm	Benign_Gastric_Neoplasm|Gastric_Mesenchymal_Neoplasm	Benign Gastric Mesenchymal Neoplasm|Benign Mesenchymal Neoplasm of Stomach|Benign Mesenchymal Neoplasm of the Stomach
C27439	Malignant_Gastric_Mesenchymal_Neoplasm	Gastric_Mesenchymal_Neoplasm|Malignant_Gastric_Neoplasm	Malignant Gastric Mesenchymal Neoplasm|Malignant Mesenchymal Neoplasm of Stomach|Malignant Mesenchymal Neoplasm of the Stomach
C27440	Gastric_Mantle_Cell_Lymphoma	Mantle_Cell_Lymphoma	Gastric Mantle Cell Lymphoma|Mantle Cell Lymphoma of Stomach|Mantle Cell Lymphoma of the Stomach	Mantle cell lymphoma of the stomach is most often a component of multifocal lymphomatous polyposis of the gastrointestinal tract and it usually has an aggressive clinical course.  -- 2003
C27441	Small_Intestinal_Mantle_Cell_Lymphoma	Mantle_Cell_Lymphoma	Small Intestinal Mantle Cell Lymphoma|Mantle Cell Lymphoma of Small Intestine|Mantle Cell Lymphoma of the Small Intestine
C27442	Gastric_Enterochromaffin-Like_Cell_Carcinoid_Tumor	Enterochromaffin-Like_Cell_Carcinoid_Tumor|Gastric_Carcinoid_Tumor	Gastric Enterochromaffin-Like Cell Carcinoid Tumor|Gastric ECL-Cell Carcinoid Tumor
C27443	Gastric_EC-Cell_Serotonin_Producing_Carcinoid_Tumor	Gastric_Carcinoid_Tumor	Gastric EC-Cell Serotonin Producing Carcinoid Tumor
C27444	Gastric_G-Cell_Gastrin_Producing_Neoplasm	G-Cell_Gastrin_Producing_Neoplasm|Gastric_Neuroendocrine_Neoplasm	Gastrin Producing Tumor of the Stomach|Gastric Gastrin Producing Neoplasm|Gastric Gastrin Producing Tumor|Gastrin Producing Neoplasm of the Stomach
C27445	Appendiceal_L-Cell_Glucagon-Like_Peptide_Producing_Neoplasm	L-Cell_Glucagon-Like_Peptide_Producing_Neoplasm	Appendiceal L-Cell Glucagon-Like Peptide Producing Tumor|Appendiceal L-Cell Glucagon-Like Peptide Producing Neoplasm
C27446	Colonic_EC-Cell_Serotonin_Producing_Tumor	Colon_Carcinoid_Tumor	Colonic EC-Cell Serotonin Producing Tumor
C27447	Colonic_L-Cell_Glucagon-Like_Peptide_Producing_Neoplasm	Colon_Neuroendocrine_Neoplasm|L-Cell_Glucagon-Like_Peptide_Producing_Neoplasm	Colonic L-Cell Glucagon-Like Peptide Producing Tumor|Colonic L-Cell Glucagon-Like Peptide Producing Neoplasm
C27448	L-Cell_Glucagon-Like_Peptide_Producing_Neoplasm	Gastrointestinal_Neuroendocrine_Neoplasm	L-Cell Glucagon-Like Peptide Producing Tumor|L-Cell Glucagon-Like Peptide Producing Neoplasm|L-Cell Glucagon-like Peptide Producing Tumor
C27449	Small_Intestinal_Small_Cell_Carcinoma	Small_Cell_Carcinoma|Small_Intestinal_Carcinoma|Small_Intestinal_Neuroendocrine_Neoplasm	Small Intestinal Small Cell Carcinoma|Small Intestinal Poorly Differentiated Endocrine Neoplasm
C27450	Small_Intestinal_G-Cell_Gastrin_Producing_Neoplasm	G-Cell_Gastrin_Producing_Neoplasm|Small_Intestinal_Neuroendocrine_Neoplasm	Small Intestinal Gastrin Producing Tumor|Small Intestinal Gastrin Producing Neoplasm
C27451	Small_Intestinal_EC-Cell_Serotonin_Producing_Tumor	Small_Intestinal_Carcinoid_Tumor	Small Intestinal EC-Cell Serotonin Producing Tumor
C27452	Small_Intestinal_L-Cell_Glucagon-Like_Peptide_Producing_Neoplasm	L-Cell_Glucagon-Like_Peptide_Producing_Neoplasm|Small_Intestinal_Neuroendocrine_Neoplasm	Small Intestinal L-Cell Glucagon-Like Peptide Producing Tumor|Small Intestinal L-Cell Glucagon-Like Peptide Producing Neoplasm|Small Intestinal L-Cell Glucagon-like Peptide Producing Tumor
C27453	Small_Intestinal_Delta_Cell_Somatostatin_Producing_Neoplasm	Delta_Cell_Somatostatin_Producing_Neoplasm|Small_Intestinal_Neuroendocrine_Neoplasm	Small Intestinal Somatostatin Producing Tumor|Small Intestinal Somatostatin Producing Neoplasm
C27454	Pancreatic_Vasoactive_Intestinal_Peptide_Producing_Neoplasm	Functioning_Pancreatic_Endocrine_Neoplasm|Vasoactive_Intestinal_Peptide_Producing_Neoplasm	Pancreatic VIP Producing Tumor|Pancreatic VIP Producing Neoplasm|Pancreatic VIPoma|Pancreatic Vasoactive Intestinal Peptide Producing Neoplasm|Pancreatic Vasoactive Intestinal Peptide Producing Tumor	A usually malignant pancreatic endocrine neoplasm secreting vasoactive intestinal peptide (VIP).  It is associated with watery diarrhea, hypokalemia, and hypochlorhydria or achlorhydria.  One third of cases are metastatic at the time of diagnosis. -- 2005
C27455	Small_Intestinal_Vasoactive_Intestinal_Peptide_Producing_Neoplasm	Small_Intestinal_Neuroendocrine_Neoplasm|Vasoactive_Intestinal_Peptide_Producing_Neoplasm	Small Intestinal VIP Producing Tumor|Small Intestinal VIP Producing Neoplasm|Small Intestinal VIPoma|Small Intestinal Vasoactive Intestinal Peptide Producing Neoplasm|Small Intestinal Vasoactive Intestinal Peptide Producing Tumor
C27456	Colorectal_Tubular_Adenoma	Colorectal_Adenoma|Tubular_Adenoma	Colorectal Tubular Adenoma
C27457	Colorectal_Adenoma_with_Moderate_Dysplasia	Colorectal_Adenoma	Colorectal Adenoma with Moderate Dysplasia
C27458	Colorectal_Adenoma_with_Mild_Dysplasia	Colorectal_Adenoma	Colorectal Adenoma with Mild Dysplasia
C27459	Colorectal_Intraepithelial_Neoplasia	Colorectal_Neoplasm|Intestinal_Intraepithelial_Neoplasia	Colorectal Intraepithelial Neoplasia|Colorectal Dysplasia
C27460	Colorectal_Low-Grade_Intraepithelial_Neoplasia	Colorectal_Intraepithelial_Neoplasia|Low_Grade_Glandular_Intraepithelial_Neoplasia	Colorectal Low Grade Intraepithelial Neoplasia|Colorectal Low-Grade Dysplasia
C27461	Colorectal_High-Grade_Intraepithelial_Neoplasia	Colorectal_Intraepithelial_Neoplasia|High_Grade_Glandular_Intraepithelial_Neoplasia	Colorectal High-Grade Intraepithelial Neoplasia|Colorectal High-Grade Dysplasia
C27462	Small_Intestinal_Intraepithelial_Neoplasia	Intestinal_Intraepithelial_Neoplasia|Small_Intestinal_Neoplasm	Small Intestinal Intraepithelial Neoplasia|Small Intestinal Dysplasia
C27463	Small_Intestinal_Low-Grade_Intraepithelial_Neoplasia	Low_Grade_Glandular_Intraepithelial_Neoplasia|Small_Intestinal_Intraepithelial_Neoplasia	Small Intestinal Low Grade Intraepithelial Neoplasia|Small Intestinal Low-Grade Dysplasia
C27464	Small_Intestinal_High-Grade_Intraepithelial_Neoplasia	High_Grade_Glandular_Intraepithelial_Neoplasia|Small_Intestinal_Intraepithelial_Neoplasia	Small Intestinal High Grade Intraepithelial Neoplasia|Small Intestinal High-Grade Dysplasia
C27465	Colon_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma|Colon_Non-Hodgkin_s_Lymphoma	Colon Burkitt's Lymphoma|Colon Burkitt Lymphoma|Primary Colon Burkitt's Lymphoma
C27466	Pancreatic_Adrenocorticotropic_Hormone_Producing_Neoplasm	Functioning_Well_Differentiated_Pancreatic_Endocrine_Carcinoma	Pancreatic ACTH Producing Tumor|Pancreatic ACTH Producing Neoplasm|Pancreatic Adrenocorticotropic Hormone Producing Neoplasm|Pancreatic Adrenocorticotropic Hormone Producing Tumor	A malignant, ectopic ACTH secreting pancreatic endocrine neoplasm, associated with Cushing's syndrome.  The prognosis is usually poor.
C27467	Stage_0_Lung_Cancer	Carcinoma_in_situ|Lung_Carcinoma	Stage 0 Lung Cancer|Bronchial Carcinoma in situ|Stage 0 Lung Carcinoma	Stage 0 includes: Tis, N0, M0.  Tis: Carcinoma in situ.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C27468	Paraproteinemia	Abnormal_Blood_and_Hematology_Test_Result	Paraproteinemia	A plasma cell disorder in which an abnormal amount of a single immunoglobulin is present in the serum. Paraproteinemias may be seen in conjunction with various carcinomas, chronic inflammatory and infectious conditions, and other diseases. --2004
C27469	Disseminated_Carcinoma	Disseminated_Malignant_Neoplasm|Metastatic_Carcinoma	Disseminated Carcinoma	Carcinoma that is spread throughout the body, a metastatic phenomenon.
C27470	Disseminated_Malignant_Neoplasm	Metastatic_Malignant_Neoplasm	Disseminated Malignant Neoplasm	Cancer that is spread throughout the body, a metastatic phenomenon.
C27471	Peripheral_Neuroectodermal_Tumor_of_Soft_Tissues	Extraosseous_Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor|Peripheral_Primitive_Neuroectodermal_Tumor	Peripheral Primitive Neuroectodermal Tumor of Soft Tissues|Peripheral Neuroectodermal Tumor of Soft Tissues|Peripheral Neuroectodermal Tumor of the Soft Tissues|Peripheral Neuroepithelioma of Soft Tissues|Peripheral Neuroepithelioma of the Soft Tissues
C27472	Proximal-Type_Epithelioid_Sarcoma	Epithelioid_Sarcoma	Proximal-Type Epithelioid Sarcoma|Central Epithelioid Sarcoma
C27473	Distal-Type_Epithelioid_Sarcoma	Epithelioid_Sarcoma	Distal-Type Epithelioid Sarcoma|Peripheral Epithelioid Sarcoma
C27474	Superficial_Bladder_Cancer	Bladder_Carcinoma	Superficial Bladder Cancer|Superficial Bladder Carcinoma|Superficial Urinary Bladder Cancer|Superficial Urinary Bladder Carcinoma	Superficial Bladder Cancer is a term used by urologists to describe infiltrating carcinomas that have not invaded into the muscularis propia of the urinary bladder wall regardless of their histologic type or grade, and therefore it does not represent a pathologic entity.  It is important for the term stage 0is bladder cancer (carcinoma in situ of the bladder) not to be equated with superficial bladder cancer.  Stage I bladder cancer may be considered superficial. --2003
C27475	Bone_Lipoma	Benign_Bone_Neoplasm|Lipoma	Bone Lipoma|Lipoma of Bone|Lipoma of the Bone
C27476	Benign_Bone_Schwannoma	Benign_Bone_Neoplasm|Benign_Schwannoma|Peripheral_Nerve_Schwannoma	Benign Bone Schwannoma|Benign Bone Neurilemmoma|Benign Neurilemmoma of Bone|Benign Neurilemmoma of the Bone|Benign Schwannoma of Bone|Benign Schwannoma of the Bone
C27477	Benign_Giant_Cell_Tumor_of_Bone	Benign_Bone_Neoplasm|Giant_Cell_Tumor_of_Bone	Benign Giant Cell Tumor of Bone|Benign Bone Giant Cell Tumor
C27478	Gingival_Angiofibroma	Angiofibroma|Benign_Gingival_Neoplasm	Gingival Angiofibroma
C27479	Nasopharyngeal_Angiofibroma	Angiofibroma|Benign_Nasopharyngeal_Neoplasm	Nasopharyngeal Angiofibroma
C27480	Myxoid_Rhabdomyoma	Fetal_Rhabdomyoma	Myxoid Rhabdomyoma
C27481	Mesenchymal_Extraskeletal_Chondrosarcoma	Extraskeletal_Chondrosarcoma|Mesenchymal_Chondrosarcoma	Mesenchymal Extraskeletal Chondrosarcoma|Extraskeletal Mesenchymal Chondrosarcoma|Mesenchymal Extraosseous Chondrosarcoma
C27482	Secondary_Chondrosarcoma	Chondrosarcoma	Secondary Chondrosarcoma
C27483	Lipoblastoma	Benign_Lipomatous_Neoplasm	Lipoblastoma|Fetal Lipoma	This type of lipoma occurs in the extremities of young children (usually boys).  The lesion is characterized by lobules of mature adipose (fatty) tissue, separated by fibrous septa.  Scattered developing lipoblasts may be seen. -- 2003
C27484	Neural_Fibrolipoma	Fibrolipoma	Neural Fibrolipoma
C27485	Hepatic_Angiomyolipoma	Angiomyolipoma|Benign_Non-Epithelial_Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm	Hepatic Angiomyolipoma
C27486	Pelvic_Lipomatosis	Lipomatosis	Pelvic Lipomatosis
C27487	Steroid_Lipomatosis	Lipomatosis	Steroid Lipomatosis
C27488	Mediastinal_Lipomatosis	Benign_Mesenchymal_Mediastinal_Neoplasm|Lipomatosis	Mediastinal Lipomatosis
C27489	Spindle_Cell_Liposarcoma	Well-Differentiated_Liposarcoma	Spindle Cell Liposarcoma
C27490	t_11_14_q13_q32	Chromosomal_Translocation	t(11;14)(q13;q32)	An adult Hodgkin's lymphoma (PDQ)
C27491	Congenital_Granular_Cell_Tumor	Benign_Miscellaneous_Mesenchymal_Neoplasm	Congenital Granular Cell Tumor
C27492	Conventional_Alveolar_Rhabdomyosarcoma	Alveolar_Rhabdomyosarcoma	Conventional Alveolar Rhabdomyosarcoma
C27493	Solid_Alveolar_Rhabdomyosarcoma	Alveolar_Rhabdomyosarcoma	Solid Alveolar Rhabdomyosarcoma
C27494	Granular_Cell_Leiomyosarcoma	Leiomyosarcoma	Granular Cell Leiomyosarcoma
C27495	Inflammatory_Leiomyosarcoma	Leiomyosarcoma	Inflammatory Leiomyosarcoma
C27496	Glomangiomatosis	Hemangiopericytic_Neoplasm	Glomangiomatosis
C27497	Glomus_Tumor_of_Uncertain_Malignant_Potential	Glomus_Tumor	Glomus Tumor of Uncertain Malignant Potential
C27498	Infantile_Hemangiopericytoma	Benign_Hemangiopericytoma	Infantile Hemangiopericytoma
C27499	Lipomatous_Hemangiopericytoma	Benign_Hemangiopericytoma	Lipomatous Hemangiopericytoma
C27500	Lymphadenopathic_Kaposi_s_Sarcoma	Kaposi_s_Sarcoma	Lymphadenopathic Kaposi's Sarcoma
C27501	Well-Differentiated_Extraskeletal_Chondrosarcoma	Extraskeletal_Chondrosarcoma|Well_Differentiated_Chondrosarcoma	Well Differentiated Extraskeletal Chondrosarcoma|Extraskeletal Well Differentiated Chondrosarcoma|Well Differentiated Extraosseous Chondrosarcoma
C27502	Myxoid_Extraskeletal_Chondrosarcoma	Extraskeletal_Chondrosarcoma|Myxoid_Chondrosarcoma	Extraskeletal Myxoid Chondrosarcoma|Myxoid Extraosseous Chondrosarcoma|Myxoid Extraskeletal Chondrosarcoma
C27503	Angiomatosis	Benign_Blood_Vessel_Neoplasm	Angiomatosis
C27504	Diffuse_Angiomatosis	Angiomatosis	Diffuse Angiomatosis|Diffuse Hemangioma
C27505	Glomeruloid_Hemangioma	Reactive_Vascular_Proliferation	Glomeruloid Hemangioma
C27506	Hobnail_Hemangioma	Hemangioma	Hobnail Hemangioma|Targetoid Hemosiderotic Hemangioma
C27507	Hemangioma_of_Peripheral_Nerve	Hemangioma|Peripheral_Nervous_System_Neoplasm	Hemangioma of Peripheral Nerve
C27508	Intra-Abdominal_Lymphangioma	Lymphangioma	Intra-Abdominal Lymphangioma
C27509	Cutaneous_Lymphangioma	Lymphangioma	Cutaneous Lymphangioma
C27510	Kaposiform_Hemangioendothelioma	Hemangioendothelioma|Intermediate_Locally_Aggressive_Blood_Vessel_Neoplasm	Kaposiform Hemangioendothelioma
C27511	Hobnail_Hemangioendothelioma	Hemangioendothelioma	Retiform Hemangioendothelioma|Hobnail Hemangioendothelioma
C27512	Angiosarcoma_Associated_with_Lymphedema	Angiosarcoma	Angiosarcoma Associated with Lymphedema
C27513	Radiation-Related_Angiosarcoma	Angiosarcoma|Radiation-Related_Malignant_Neoplasm	Radiation-Related Angiosarcoma|Radiation-Induced Angiosarcoma
C27514	Adult_Xanthogranuloma	Xanthogranuloma	Adult Xanthogranuloma
C27515	Sclerotic_Fibroma	Dermal_Fibroma	Sclerotic Fibroma
C27516	Epidermolytic_Acanthoma	Acanthoma	Epidermolytic Acanthoma
C27517	Acantholytic_Acanthoma	Acanthoma	Acantholytic Acanthoma
C27518	Large_Cell_Acanthoma	Acanthoma	Large Cell Acanthoma
C27519	Epidermolysis_Verruciformis	Benign_Verrucous_Lesion	Epidermolysis Verruciformis
C27520	Benign_Hair_Follicle_Neoplasm	Benign_Skin_Appendage_Neoplasm|Hair_Follicle_Neoplasm	Benign Hair Follicle Neoplasm|Benign Follicular Neoplasm|Benign Follicular Tumor|Benign Hair Follicle Tumor
C27521	Classic_Type_Trichilemmoma	Trichilemmoma	Classic Type Trichilemmoma
C27522	Desmoplastic_Trichilemmoma	Trichilemmoma	Desmoplastic Trichilemmoma
C27523	Classic_Type_Trichoepithelioma	Trichoepithelioma	Classic Type Trichoepithelioma
C27524	Desmoplastic_Trichoepithelioma	Trichoepithelioma	Desmoplastic Trichoepithelioma|Sclerosing Epithelial Hamartoma
C27525	Trichoblastic_Fibroma	Retired_Concepts	Trichoblastic Fibroma
C27526	Trichogenic_Myxoma	Benign_Pilar-Associated_Mesenchyme_Neoplasm|Cutaneous_Myxoma	Follicular Myxoma|Trichogenic Myxoma
C27527	Tubular_Apocrine_Adenoma	Apocrine_Adenoma	Tubular Apocrine Adenoma
C27528	Angiokeratoma_Corporis_Diffusum	Skin_Angiokeratoma	Angiokeratoma Corporis Diffusum
C27529	Malignant_Cutaneous_Vascular_Neoplasm	Cutaneous_Vascular_Neoplasm|Malignant_Vascular_Neoplasm	Malignant Cutaneous Vascular Neoplasm|Malignant Cutaneous Vascular Tumor|Malignant Skin Vascular Neoplasm|Malignant Skin Vascular Tumor
C27530	Classic_Type_Lipoma	Lipoma	Classic Type Lipoma
C27531	Pre-Malignant_Skin_Epithelial_Lesions	Cutaneous_Precancerous_Condition|Epithelial_Skin_Neoplasm	Pre-Malignant Skin Epithelial Lesion
C27532	Malignant_Acrospiroma	Retired_Concepts	Malignant Acrospiroma
C27533	Adnexal_Mucinous_Adenocarcinoma	Eccrine_Adenocarcinoma|Mucinous_Adenocarcinoma	Mucinous Eccrine Carcinoma
C27534	Aggressive_Digital_Papillary_Adenocarcinoma	Eccrine_Papillary_Adenocarcinoma	Papillary Digital Eccrine Carcinoma
C27535	Adenoid_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma	Skin Adenoid Basal Cell Carcinoma
C27536	Clear_Cell_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma	Skin Clear Cell Basal Cell Carcinoma	A morphologic variant of basal cell carcinoma characterized by the presence of clear cells.
C27537	Cystic_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma	Skin Cystic Basal Cell Carcinoma
C27538	Follicular_Pilar_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma	Follicular (Pilar) Basal Cell Carcinoma
C27539	Infiltrating_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma	Skin Infiltrating Basal Cell Carcinoma
C27540	Infundibulocystic_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma	Skin Infundibulocystic Basal Cell Carcinoma
C27541	Micronodular_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma	Skin Micronodular Basal Cell Carcinoma
C27542	Skin_Pseudovascular_Squamous_Cell_Carcinoma	Skin_Squamous_Cell_Carcinoma	Skin Pseudovascular Squamous Cell Carcinoma|Pseudovascular Skin Squamous Cell Carcinoma
C27543	Skin_Basaloid_Squamous_Cell_Carcinoma	Basaloid_Carcinoma|Skin_Squamous_Cell_Carcinoma	Skin Basaloid Carcinoma|Basaloid Skin Squamous Cell Carcinoma|Skin Basaloid Squamous Cell Carcinoma
C27544	Retiform_Hemangioendothelioma	Retired_Concepts	Retiform Hemangioendothelioma
C27545	Classic_Type_Atypical_Fibroxanthoma	Atypical_Fibroxanthoma	Classic Type Atypical Fibroxanthoma
C27546	Spindle_Cell_Type_Atypical_Fibroxanthoma	Atypical_Fibroxanthoma	Spindle Cell Type Atypical Fibroxanthoma
C27547	Fibrosarcomatous_Dermatofibrosarcoma_Protuberans	Dermatofibrosarcoma_Protuberans	Fibrosarcomatous Dermatofibrosarcoma Protuberans
C27548	Melanoacanthoma	Seborrheic_Keratosis	Melanoacanthoma
C27549	Reactive_Cutaneous_Fibrous_Lesions	Non-Neoplastic_Skin_Disorder	Reactive Cutaneous Fibrous Lesions
C27550	Non-Neoplastic_Gastrointestinal_Disorder	Gastrointestinal_Disorder	Non-Neoplastic Gastrointestinal Disorder
C27551	Disorder_by_Site	Diseases_and_Disorders	Disorder by Site|Disease by Site
C27552	Multiple_Lobular_Capillary_Hemangiomas	Lobular_Capillary_Hemangioma	Multiple Lobular Capillary Hemangiomas|Multiple Pyogenic Granulomas
C27553	Genital_Human_Papilloma_Virus_Infection	Anogenital_Human_Papilloma_Virus_Infection	Genital Human Papilloma Virus Infection
C27554	Dermatosis	Non-Neoplastic_Skin_Disorder	Dermatosis	A disorder involving lesions or eruptions of the skin, usually without inflammation.
C27555	Non-Neoplastic_Skin_Disorder	Skin_Disorder	Non-Neoplastic Skin Disorder|Non-Neoplastic Cutaneous Disorder
C27556	Non-Neoplastic_Skin_Cyst	Retired_Concepts	Non-Neoplastic Skin Cyst
C27557	Non-Neoplastic_Lung_Disorder	Lung_Disorder|Non-Neoplastic_Respiratory_Disorder|Non-Neoplastic_Thoracic_Disorder	Non-Neoplastic Lung Disorder|Non-Neoplastic Pulmonary Disorder|Non-neoplastic Lung Disorders|Non-neoplastic Pulmonary Disease|Non-neoplastic Pulmonary Diseases
C27558	Lymphocytic_Interstitial_Pneumonitis	Idiopathic_Interstitial_Pneumonia	Lymphocytic Interstitial Pneumonia|Diffuse Hyperplasia of Bronchus-Associated Lymphoid Tissue|LIP|Lymphocytic Interstitial Pneumonitis	Mitelman_Code: 201
C27559	Mixed_Mineral_Dust_Pneumoconiosis	Pneumoconiosis	Mixed Mineral Dust Pneumoconiosis
C27560	Neonatal_Respiratory_Distress_Syndrome	Hyaline_Membrane_Syndrome|Respiratory_Distress_Syndrome	Neonatal Respiratory Distress Syndrome	a condition of the newborn marked by dyspnea with cyanosis, heralded by such prodromal signs as dilatation of the alae nasi, expiratory grunt, and retraction of the suprasternal notch or costal margins, most frequently occurring in premature infants, children of diabetic mothers, and infants delivered by cesarean section, and sometimes with no apparent predisposing cause.
C27561	Respiratory_Distress_Syndrome	Respiratory_Failure|Syndrome	Respiratory Distress Syndrome
C27562	Hyaline_Membrane_Syndrome	Non-Neoplastic_Lung_Disorder	Hyaline Membrane Syndrome
C27563	Non-Neoplastic_Pleural_Disorder	Non-Neoplastic_Thoracic_Disorder|Pleural_Disorder	Non-Neoplastic Pleural Disorder|Non-Neoplastic Pleural Disease
C27564	Endocrine_Syndrome	Endocrine_Disorder|Syndrome	Endocrine Syndrome
C27565	Non-Neoplastic_Endocrine_Disorder	Endocrine_Disorder	Non-Neoplastic Endocrine Disorder
C27566	Non-Neoplastic_Thyroid_Gland_Disorder	Non-Neoplastic_Neck_Disorder|Thyroid_Gland_Disorder	Non-Neoplastic Thyroid Gland Disorder
C27567	Non-Neoplastic_Pituitary_Gland_Disorder	Pituitary_Gland_Disorder	Non-Neoplastic Pituitary Gland Disorder
C27568	Non-Neoplastic_Parathyroid_Gland_Disorder	Non-Neoplastic_Neck_Disorder|Parathyroid_Gland_Disorder	Non-Neoplastic Parathyroid Gland Disorder
C27569	Non-Neoplastic_Adrenal_Gland_Disorder	Adrenal_Gland_Disorder|Non-Neoplastic_Retroperitoneal_Disorder	Non-Neoplastic Adrenal Gland Disorder
C27570	Non-Neoplastic_Gonadal_Disorder	Gonadal_Disorder	Non-Neoplastic Gonadal Disorder
C27571	Head_and_Neck_Disorder	Disorder_by_Site	Head and Neck Disorder
C27572	Non-Neoplastic_Bone_Disorder	Connective_Tissue_Disorder|Non-Neoplastic_Connective_and_Soft_Tissue_Disorder	Non-Neoplastic Bone Disorder
C27573	Non-Neoplastic_Soft_Tissue_Disorder	Non-Neoplastic_Connective_and_Soft_Tissue_Disorder|Soft_Tissue_Disorder	Non-Neoplastic Soft Tissue Disorder
C27574	Connective_and_Soft_Tissue_Disorder	Disorder_by_Site	Connective and Soft Tissue Disorder|Connective and Soft Tissue Disease|Connective and Soft Tissue Diseases
C27575	Idiopathic_Granulomatous_Myositis	Myositis	Idiopathic Granulomatous Myositis
C27576	Childhood_Dermatomyositis	Dermatomyositis	Childhood Dermatomyositis
C27577	Osteomyelitis	Bone_Infection	Osteomyelitis
C27578	Myositis	Non-Neoplastic_Soft_Tissue_Disorder	Myositis
C27579	Hyperimmunoglobulin_Syndrome	Genetic_Disorder	Hyperimmunoglobulin Syndrome
C27580	Peripheral_Nervous_System_Disorder	Nervous_System_Disorder	Peripheral Nervous System Disorder|Peripheral Nervous System Disease
C27581	Meningeal_Fibrosis	Fibrosis	Meningeal Fibrosis
C27582	Central_Nervous_System_Infectious_Disorder	Nervous_System_Infectious_Disorder|Non-Neoplastic_Central_Nervous_System_Disorder	Central Nervous System Infectious Disorder|Central Nervous System Infectious Disease
C27583	Infectious_Disorder_by_Site	Infectious_Disorder	Infectious Disorder by Site
C27584	HIV_Leukoencephalopathy	Leukoencephalopathy	HIV Leukoencephalopathy
C27585	Spongiform_Encephalopathy	Central_Nervous_System_Infectious_Disorder	Spongiform Encephalopathy
C27586	Non-Neoplastic_Central_Nervous_System_Disorder	Central_Nervous_System_Disorder|Non-Neoplastic_Nervous_System_Disorder	Non-Neoplastic Central Nervous System Disorder|Non-Neoplastic Central Nervous System Disease
C27587	Non-Neoplastic_Peripheral_Nervous_System_Disorder	Non-Neoplastic_Nervous_System_Disorder|Peripheral_Nervous_System_Disorder	Non-Neoplastic Peripheral Nervous System Disorder|Non-Neoplastic Peripheral Nervous System Disease
C27588	Non-Neoplastic_Nervous_System_Disorder	Nervous_System_Disorder	Non-Neoplastic Nervous System Disorder
C27589	Peripheral_Nervous_System_Infectious_Disorder	Nervous_System_Infectious_Disorder|Non-Neoplastic_Peripheral_Nervous_System_Disorder	Peripheral Nervous System Infectious Disorder
C27590	Nervous_System_Infectious_Disorder	Infectious_Disorder_by_Site	Nervous System Infectious Disorder
C27591	Vagus_Nerve_Disorder	Cranial_Nerve_Disorder	Vagus Nerve Disorder
C27592	Abducent_Nerve_Paralysis	Abducens_Nerve_Disorder|Cranial_Nerve_Paralysis	Abducent Nerve Paralysis|Sixth Nerve Paralysis|VIth Nerve Paralysis
C27593	Abducens_Nerve_Disorder	Cranial_Nerve_Disorder	Abducens Nerve Disorder|VIth Nerve Disorder
C27594	Facial_Nerve_Disorder	Cranial_Nerve_Disorder	Facial Nerve Disorder
C27595	Femoral_Neuropathy	Neuropathy	Femoral Neuropathy
C27596	Peroneal_Neuropathy	Neuropathy	Peroneal Neuropathy
C27597	Oculomotor_Nerve_Paralysis	Cranial_Nerve_Paralysis|Oculomotor_Nerve_Disorder	Oculomotor Nerve Paralysis|IIIrd Nerve Paralysis
C27598	Oculomotor_Nerve_Disorder	Cranial_Nerve_Disorder	Oculomotor Nerve Disorder
C27599	Non-Neoplastic_Urinary_Tract_Disorder	Urinary_Tract_Disorder	Non-Neoplastic Urinary Tract Disorder|Non-Neoplastic Urinary Tract Disease
C27600	Non-Neoplastic_Renal_Disorder	Non-Neoplastic_Urinary_Tract_Disorder|Renal_Disorder	Non-Neoplastic Renal Disorder
C27601	Non-Neoplastic_Bladder_Disorder	Bladder_Disorder|Non-Neoplastic_Urinary_Tract_Disorder	Non-Neoplastic Bladder Disorder
C27602	Non-Neoplastic_Urethra_Disorder	Non-Neoplastic_Urinary_Tract_Disorder|Urethra_Disorder	Non-Neoplastic Urethra Disorder|Non-Neoplastic Urethra Disease
C27603	Non-Neoplastic_Ureter_Disorder	Non-Neoplastic_Urinary_Tract_Disorder|Ureter_Disorder	Non-Neoplastic Ureter Disorder
C27604	Non-Neoplastic_Eye_Disorder	Eye_Disorder	Non-Neoplastic Eye Disorder|Non-Neoplastic Eye Disease
C27605	Conjunctival_Disorder	Eye_Disorder	Conjunctival Disorder|Conjunctival Disease
C27606	Conjuctivitis	Retired_Concepts	Conjuctivitis
C27607	Non-Neoplastic_Conjunctival_Disorder	Conjunctival_Disorder|Non-Neoplastic_Eye_Disorder	Non-Neoplastic Conjunctival Disorder
C27608	Non-Neoplastic_Corneal_Disorder	Corneal_Disorder|Non-Neoplastic_Eye_Disorder	Non-Neoplastic Corneal Disorder
C27609	Non-Neoplastic_Eyelid_Disorder	Eyelid_Disorder|Non-Neoplastic_Eye_Disorder	Non-Neoplastic Eyelid Disorder
C27610	Non-Neoplastic_Retinal_Disorder	Non-Neoplastic_Eye_Disorder|Retinal_Disorder	Non-Neoplastic Retinal Disorder
C27611	Male_Non-Neoplastic_Reproductive_System_Disorder	Male_Reproductive_System_Disorder|Non-Neoplastic_Reproductive_System_Disorder	Male Non-Neoplastic Reproductive System Disorder|Male Non-Neoplastic Reproductive System Disease
C27612	Female_Non-Neoplastic_Reproductive_System_Disorder	Female_Reproductive_System_Disorder|Non-Neoplastic_Reproductive_System_Disorder	Female Non-Neoplastic Reproductive System Disorder|Female Non-Neoplastic Reproductive System Disease
C27613	Non-Neoplastic_Reproductive_System_Disorder	Reproductive_System_Disorder	Non-Neoplastic Reproductive System Disorder|Non-Neoplastic Reproductive System Disease
C27614	Prostate_Non-Neoplastic_Disorder	Male_Non-Neoplastic_Reproductive_System_Disorder|Prostate_Disorder	Prostate Non-Neoplastic Disorder|Prostate Non-Neoplastic Disease
C27615	Prostatic_Infection	Genitourinary_System_Infection|Prostate_Non-Neoplastic_Disorder	Prostatic Infection
C27616	Testicular_Non-Neoplastic_Disorder	Male_Non-Neoplastic_Reproductive_System_Disorder|Testicular_Disorder	Testicular Non-Neoplastic Disorder|Testicular Non-Neoplastic Disease
C27617	Testicular_Infarction	Testicular_Non-Neoplastic_Disorder	Testicular Infarction
C27618	Penile_Non-Neoplastic_Disorder	Male_Non-Neoplastic_Reproductive_System_Disorder|Penile_Disorder	Penile Non-Neoplastic Disorder
C27619	Placental_Non-Neoplastic_Disorder	Female_Non-Neoplastic_Reproductive_System_Disorder|Placenta_Disorder	Placental Non-Neoplastic Disorder|Non-Neoplastic Placenta Disorder|Placental Non-Neoplastic Disease
C27620	Vulvar_Non-Neoplastic_Disorder	Female_Non-Neoplastic_Reproductive_System_Disorder|Vulvar_Disorder	Vulvar Non-Neoplastic Disorder|Vulvar Non-Neoplastic Disease
C27621	Vaginal_Non-Neoplastic_Disorder	Female_Non-Neoplastic_Reproductive_System_Disorder|Vaginal_Disorder	Vaginal Non-Neoplastic Disorder|Vaginal Non-Neoplastic Disease
C27622	Cervical_Non-Neoplastic_Disorder	Cervical_Disorder|Uterine_Non-Neoplastic_Disorder	Cervical Non-Neoplastic Disorder|Cervical Non-Neoplastic Disease
C27623	Cervical_Endometriosis	Cervical_Non-Neoplastic_Disorder|Endometriosis	Cervical Endometriosis
C27624	Uterine_Corpus_Non-Neoplastic_Disorder	Uterine_Non-Neoplastic_Disorder	Uterine Corpus Non-Neoplastic Disorder|Uterine Corpus Non-Neoplastic Disease
C27625	Non_Specific_Chronic_Endometritis	Endometritis	Non Specific Chronic Endometritis
C27626	Granulomatous_Endometritis	Endometritis	Granulomatous Endometritis
C27627	Ovarian_Non-Neoplastic_Disorder	Female_Non-Neoplastic_Reproductive_System_Disorder|Ovarian_Disorder	Ovarian Non-Neoplastic Disorder|Ovarian Non-Neoplastic Disease
C27628	Ovarian_Endometriosis	Endometriosis|Ovarian_Non-Neoplastic_Disorder	Ovarian Endometriosis
C27629	Uterine_Non-Neoplastic_Disorder	Female_Non-Neoplastic_Reproductive_System_Disorder|Uterine_Disorder	Uterine Non-Neoplastic Disorder|Uterine Non-Neoplastic Disease
C27630	Fallopian_Tube_Non-Neoplastic_Disorder	Fallopian_Tube_Disorder|Female_Non-Neoplastic_Reproductive_System_Disorder	Fallopian Tube Non-Neoplastic Disorder|Fallopian Tube Non-Neoplastic Disease
C27631	Vulvar_Disorder	Female_Reproductive_System_Disorder	Vulvar Disorder|Vulvar Disease
C27632	Transplant-Related_Malignant_Neoplasm	Immunodeficiency-Related_Malignant_Neoplasm|Transplant-Related_Disorder	Transplant-Related Malignant Neoplasm|Transplant-Related Cancer|Transplant-Related Malignancy
C27633	Transplant-Related_Carcinoma	Carcinoma|Transplant-Related_Malignant_Neoplasm	Transplant-Related Carcinoma
C27634	Transplant-Related_Urothelial_Transitional_Cell_Carcinoma	Bladder_Urothelial_Carcinoma|Transplant-Related_Carcinoma	Transplant-Related Bladder Urothelial Carcinoma|Transplant-Related Bladder Transitional Cell Carcinoma
C27635	Transplant-Related_Hepatocellular_Carcinoma	Hepatocellular_Carcinoma|Transplant-Related_Carcinoma	Transplant-Related Hepatocellular Carcinoma
C27636	Transplant-Related_Skin_Squamous_Cell_Carcinoma	Skin_Squamous_Cell_Carcinoma|Transplant-Related_Carcinoma	Transplant-Related Skin Squamous Cell Carcinoma
C27637	Transplant-Related_Lung_Carcinoma	Lung_Carcinoma|Transplant-Related_Carcinoma	Transplant-Related Lung Carcinoma	A lung carcinoma in a patient with a history of organ transplantation. (NCI05)
C27638	Transplant-Related_Renal_Cell_Carcinoma	Renal_Cell_Carcinoma|Transplant-Related_Carcinoma	Transplant-Related Renal Cell Carcinoma
C27639	Transplant-Related_Hematologic_Malignancy	Hematopoietic_Cell_Neoplasm|Transplant-Related_Malignant_Neoplasm	Transplant-Related Hematologic Malignancy
C27640	Transplant-Related_Kaposi_s_Sarcoma	Iatrogenic_Kaposi_s_Sarcoma|Transplant-Related_Malignant_Neoplasm	Transplant-Related Kaposi's Sarcoma
C27641	Oral_Cavity_Disorder	Oral_Disorder	Oral Cavity Disorder|Oral Cavity Disease
C27642	Head_and_Neck_Precancerous_Condition	Head_and_Neck_Disorder|Precancerous_Condition_by_Site	Head and Neck Precancerous Condition
C27643	Partial_Hearing_Loss	Hearing_Loss	Partial Hearing Loss
C27644	Deafness	Hearing_Loss	Deafness
C27645	Conductive_Hearing_Loss	Hearing_Loss	Conductive Hearing Loss
C27646	Conductive_Deafness	Conductive_Hearing_Loss|Deafness	Conductive Deafness
C27647	Nasal_Cavity_and_Paranasal_Sinus_Disorder	Head_and_Neck_Disorder	Nasal Cavity and Paranasal Sinus Disorder
C27648	Neck_Disorder	Head_and_Neck_Disorder	Neck Disorder|Neck Disease
C27649	Salivary_Cyst	Cyst|Head_and_Neck_Finding	Salivary Cyst
C27650	Non-Neoplastic_Oral_Disorder	Non-Neoplastic_Head_and_Neck_Disorder|Oral_Disorder	Non-Neoplastic Oral Disorder|Non-Neoplastic Oral Disease
C27651	Non-Neoplastic_Oral_Cavity_Disorder	Non-Neoplastic_Oral_Disorder|Oral_Cavity_Disorder	Non-Neoplastic Oral Cavity Disorder
C27652	Non-Neoplastic_Ear_Disorder	Ear_Disorder|Non-Neoplastic_Head_and_Neck_Disorder	Non-Neoplastic Ear Disorder|Non-Neoplastic Ear Disease
C27653	Non-Neoplastic_External_Ear_Disorder	External_Ear_Disorder|Non-Neoplastic_Ear_Disorder	Non-Neoplastic External Ear Disorder|Non-Neoplastic External Ear Disease
C27654	Non-Neoplastic_Inner_Ear_Disorder	Inner_Ear_Disorder|Non-Neoplastic_Ear_Disorder	Non-Neoplastic Inner Ear Disorder|Non-Neoplastic Inner Ear Disease
C27655	Skull_Disorder	Head_and_Neck_Disorder	Skull Disorder|Skull Disease
C27656	Non-Neoplastic_Nasal_Cavity_and_Paranasal_Sinus_Disorder	Nasal_Cavity_and_Paranasal_Sinus_Disorder|Non-Neoplastic_Head_and_Neck_Disorder	Non-Neoplastic Nasal Cavity and Paranasal Sinus Disorder|Non-Neoplastic Nasal Cavity and Paranasal Sinus Disease
C27657	Non-Neoplastic_Paranasal_Sinus_Disorder	Non-Neoplastic_Nasal_Cavity_and_Paranasal_Sinus_Disorder|Paranasal_Sinus_Disorder	Non-Neoplastic Paranasal Sinus Disorder|Non-Neoplastic Paranasal Sinus Disease
C27658	Non-Neoplastic_Nasal_Cavity_Disorder	Nasal_Cavity_Disorder|Non-Neoplastic_Nasal_Cavity_and_Paranasal_Sinus_Disorder	Non-Neoplastic Nasal Cavity Disorder|Non-Neoplastic Nasal Cavity Disease
C27659	Non-Neoplastic_Laryngeal_Disorder	Laryngeal_Disorder|Non-Neoplastic_Neck_Disorder	Non-Neoplastic Laryngeal Disorder|Non-Neoplastic Laryngeal Disease
C27660	Non-Neoplastic_Neck_Disorder	Neck_Disorder|Non-Neoplastic_Head_and_Neck_Disorder	Non-Neoplastic Neck Disorder|Non-Neoplastic Neck Disease
C27661	Non-Neoplastic_Pharyngeal_Disorder	Non-Neoplastic_Neck_Disorder|Pharyngeal_Disorder	Non-Neoplastic Pharyngeal Disorder|Non-Neoplastic Pharyngeal Disease
C27662	Non-Neoplastic_Salivary_Gland_Disorder	Non-Neoplastic_Head_and_Neck_Disorder|Salivary_Gland_Disorder	Non-Neoplastic Salivary Gland Disorder|Non-Neoplastic Salivary Gland Disease
C27663	Non-Neoplastic_Head_and_Neck_Disorder	Head_and_Neck_Disorder	Non-Neoplastic Head and Neck Disorder|Non-Neoplastic Head and Neck Disease
C27664	Peritoneal_and_Retroperitoneal_Disorder	Disorder_by_Site	Peritoneal and Retroperitoneal Disorder|Peritoneal and Retroperitoneal Disease
C27665	Non-Neoplastic_Peritoneal_and_Retroperitoneal_Disorder	Peritoneal_and_Retroperitoneal_Disorder	Non-Neoplastic Peritoneal and Retroperitoneal Disorder|Non-Neoplastic Peritoneal and Retroperitoneal Disease
C27666	Non-Neoplastic_Peritoneal_Disorder	Non-Neoplastic_Peritoneal_and_Retroperitoneal_Disorder|Peritoneal_Disorder	Non-Neoplastic Peritoneal Disorder|Non-Neoplastic Peritoneal Disease
C27667	Retroperitoneal_Disorder	Peritoneal_and_Retroperitoneal_Disorder	Retroperitoneal Disorder|Retroperitoneal Disease
C27668	Non-Neoplastic_Retroperitoneal_Disorder	Non-Neoplastic_Peritoneal_and_Retroperitoneal_Disorder|Retroperitoneal_Disorder	Non-Neoplastic Retroperitoneal Disorder|Non-Neoplastic Retroperitoneal Disease
C27669	Respiratory_and_Thoracic_Disorder	Disorder_by_Site	Respiratory and Thoracic Disorder|Respiratory and Thoracic Disease|Respiratory, Thoracic, and Mediastinal Disease|Respiratory, Thoracic, and Mediastinal Disorder
C27670	Non-Neoplastic_Respiratory_Thoracic_and_Mediastinal_Disorder	Retired_Concepts	Non-Neoplastic Respiratory, Thoracic, and Mediastinal Disorder|Non-Neoplastic Respiratory, Thoracic, and Mediastinal Disease
C27671	Non-Neoplastic_Mediastinal_Disorder	Mediastinal_Disorder|Non-Neoplastic_Thoracic_Disorder	Non-Neoplastic Mediastinal Disorder|Non-Neoplastic Mediastinal Disease
C27672	Non-Neoplastic_Cardiovascular_Disorder	Cardiovascular_Disorder	Non-Neoplastic Cardiovascular Disorder|Non-Neoplastic Cardiovascular Disease
C27673	Virus-Related_Malignant_Neoplasm	Infection-Related_Malignant_Neoplasm	Virus-Related Malignant Neoplasm|Virus Related Cancer|Virus Related Malignancy|Virus-Related Cancer|Virus-Related Malignancy	This category currently includes only malignancies in which there is a well documented association between the neoplastic process and a specific virus as a causative agent.--2003
C27674	Human_Papilloma_Virus-Related_Carcinoma	Human_Papilloma_Virus-Related_Malignant_Neoplasm|Virus-Related_Carcinoma	Human Papilloma Virus-Related Carcinoma|HPV-Related Carcinoma|Human Papilloma Virus Related Carcinoma
C27675	Human_Papilloma_Virus-Related_Cervical_Carcinoma	Cervical_Carcinoma|Human_Papilloma_Virus-Related_Carcinoma	Human Papilloma Virus-Related Cervical Carcinoma|HPV-Related Cervical Carcinoma|Human Papilloma Virus Related Cervical Carcinoma
C27676	Human_Papilloma_Virus-Related_Cervical_Squamous_Cell_Carcinoma	Cervical_Squamous_Cell_Carcinoma|Human_Papilloma_Virus-Related_Cervical_Carcinoma|Human_Papilloma_Virus-Related_Squamous_Cell_Carcinoma	Human Papilloma Virus-Related Cervical Squamous Cell Carcinoma|HPV-Related Cervical Squamous Cell Carcinoma|Human Papilloma Virus Related Cervical Squamous Cell Carcinoma
C27677	Human_Papilloma_Virus-Related_Endocervical_Adenocarcinoma	Cervical_Adenocarcinoma|Human_Papilloma_Virus-Related_Adenocarcinoma|Human_Papilloma_Virus-Related_Cervical_Carcinoma	Human Papilloma Virus-Related Endocervical Adenocarcinoma|HPV-Related Endocervical Adenocarcinoma|Human Papilloma Virus Related Endocervical Adenocarcinoma
C27678	Human_Papilloma_Virus-Related_Verrucous_Carcinoma	Human_Papilloma_Virus-Related_Squamous_Cell_Carcinoma|Verrucous_Carcinoma	Human Papilloma Virus-Related Verrucous Carcinoma|HPV-Related Verrucous Carcinoma|Human Papilloma Virus Related Verrucous Carcinoma
C27679	Human_Papilloma_Virus-Related_Vulvar_Squamous_Cell_Carcinoma	Human_Papilloma_Virus-Related_Squamous_Cell_Carcinoma|Vulvar_Squamous_Cell_Carcinoma	Human Papilloma Virus-Related Vulvar Squamous Cell Carcinoma|HPV-Related Vulvar Squamous Cell Carcinoma|Human Papilloma Virus Related Vulvar Squamous Cell Carcinoma
C27680	Human_Papilloma_Virus-Related_Esophageal_Squamous_Cell_Carcinoma	Esophageal_Squamous_Cell_Carcinoma|Human_Papilloma_Virus-Related_Squamous_Cell_Carcinoma	Human Papilloma Virus-Related Esophageal Squamous Cell Carcinoma|HPV-Related Esophageal Squamous Cell Carcinoma|Human Papilloma Virus Related Esophageal Squamous Cell Carcinoma
C27681	Human_Papilloma_Virus-Related_Anal_Squamous_Cell_Carcinoma	Anal_Squamous_Cell_Carcinoma|Human_Papilloma_Virus-Related_Squamous_Cell_Carcinoma	Human Papilloma Virus-Related Anal Squamous Cell Carcinoma|HPV-Related Anal Squamous Cell Carcinoma|Human Papilloma Virus Related Anal Squamous Cell Carcinoma
C27682	Human_Papilloma_Virus-Related_Penile_Squamous_Cell_Carcinoma	Human_Papilloma_Virus-Related_Squamous_Cell_Carcinoma|Squamous_Cell_Carcinoma_of_the_Penis	Human Papilloma Virus-Related Penile Squamous Cell Carcinoma|HPV-Related Penile Squamous Cell Carcinoma|Human Papilloma Virus Related Penile Squamous Cell Carcinoma
C27683	Human_Papilloma_Virus-Related_Squamous_Cell_Carcinoma	Human_Papilloma_Virus-Related_Carcinoma|Squamous_Cell_Carcinoma	Human Papilloma Virus-Related Squamous Cell Carcinoma|HPV-Related Squamous Cell Carcinoma|Human Papilloma Virus Related Squamous Cell Carcinoma
C27684	Human_Papilloma_Virus-Related_Adenocarcinoma	Adenocarcinoma|Human_Papilloma_Virus-Related_Carcinoma	Human Papilloma Virus-Related Adenocarcinoma|HPV-Related Adenocarcinoma|Human Papilloma Virus Related Adenocarcinoma
C27685	HTLV-1-Related_Malignant_Neoplasm	Virus-Related_Malignant_Neoplasm	HTLV-1-Related Malignant Neoplasm|HTLV-1 Related Malignancy
C27686	Hepatitis_Virus-Related_Hepatocellular_Carcinoma	Hepatocellular_Carcinoma|Virus-Related_Carcinoma	Hepatitis Virus-Related Hepatocellular Carcinoma|Hepatitis Virus Related Hepatocellular Carcinoma
C27687	Hepatitis_B_Virus-Related_Hepatocellular_Carcinoma	Hepatitis_Virus-Related_Hepatocellular_Carcinoma	Hepatitis B Virus-Related Hepatocellular Carcinoma|Hepatitis B Virus Related Hepatocellular Carcinoma
C27688	Hepatitis_C_Virus-Related_Hepatocellular_Carcinoma	Hepatitis_Virus-Related_Hepatocellular_Carcinoma	Hepatitis C Virus-Related Hepatocellular Carcinoma|Hepatitis C Virus Related Hepatocellular Carcinoma
C27689	Epstein-Barr_Virus-Related_Malignant_Neoplasm	Virus-Related_Malignant_Neoplasm	Epstein-Barr Virus-Related Malignant Neoplasm|EBV Related Malignancy|EBV-Related Malignancy|Epstein-Barr Virus Related Malignancy|Epstein-Barr Virus-Related Malignancy
C27690	Epstein-Barr_Virus-Related_Carcinoma	Epstein-Barr_Virus-Related_Malignant_Neoplasm|Virus-Related_Carcinoma	Epstein-Barr Virus-Related Carcinoma|EBV Related Carcinoma|EBV-Related Carcinoma|Epstein-Barr Virus Related Carcinoma
C27691	Epstein-Barr_Virus-Related_Lymphoma	Epstein-Barr_Virus-Related_Malignant_Neoplasm|Virus-Related_Lymphoma	Epstein-Barr Virus-Related Lymphoma|EBV Related Lymphoma|EBV-Related Lymphoma|Epstein-Barr Virus Related Lymphoma
C27692	Epstein-Barr_Virus-Related_Hodgkin_s_Lymphoma	Epstein-Barr_Virus-Related_Lymphoma|Hodgkin_s_Lymphoma	Epstein-Barr Virus-Related Hodgkin's Lymphoma|EBV Related Hodgkin's Lymphoma|EBV-Related Hodgkin's Lymphoma|Epstein-Barr Virus Related Hodgkin's Lymphoma
C27693	Epstein-Barr_Virus-Related_Non-Hodgkin_s_Lymphoma	Epstein-Barr_Virus-Related_Lymphoma|Non-Hodgkin_s_Lymphoma	Epstein-Barr Virus-Related Non-Hodgkin's Lymphoma|EBV Related Non-Hodgkin's Lymphoma|EBV-Related Non-Hodgkin's Lymphoma|Epstein-Barr Virus Related Non-Hodgkin's Lymphoma
C27694	Epstein-Barr_Virus-Related_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma|Epstein-Barr_Virus-Related_Non-Hodgkin_s_Lymphoma	Epstein-Barr Virus-Related Burkitt's Lymphoma|EBV Related Burkitt's Lymphoma|EBV-Related Burkitt's Lymphoma
C27695	Epstein-Barr_Virus-Related_Clonal_Post-Transplant_Lymphoproliferative_Disorder	Epstein-Barr_Virus-Related_Lymphoma|Epstein-Barr_Virus-Related_Post-Transplant_Lymphoproliferative_Disorder|Neoplastic_Post-Transplant_Lymphoproliferative_Disorder|Transplant-Related_Hematologic_Malignancy	Epstein-Barr Virus-Related Clonal Post-Transplant Lymphoproliferative Disorder|EBV Related Clonal PTLD|EBV-Related Clonal PTLD
C27696	Epstein-Barr_Virus-Related_Post-Transplant_Lymphoproliferative_Disorder	Post-Transplant_Lymphoproliferative_Disorder	Epstein-Barr Virus-Related Post-Transplant Lymphoproliferative Disorder|EBV-Related PTLD
C27697	Human_Herpes_Virus_8-Related_Malignant_Neoplasm	Virus-Related_Malignant_Neoplasm	Human Herpes Virus 8-Related Malignant Neoplasm|HHV-8 Related Malignancy|HHV-8-Related Malignancy|Human Herpes Virus 8 Related Malignancy|Human Herpes Virus 8-Related Malignancy
C27698	Virus-Related_Carcinoma	Carcinoma|Virus-Related_Malignant_Neoplasm	Virus-Related Carcinoma|Virus Related Carcinoma
C27699	Virus-Related_Lymphoma	Lymphoma|Virus-Related_Malignant_Neoplasm	Virus-Related Lymphoma|Virus Related Lymphoma
C27700	AIDS-Related_Carcinoma	AIDS-Related_Malignant_Neoplasm|Virus-Related_Carcinoma	AIDS-Related Carcinoma|AIDS Related Carcinoma
C27701	Secondary_Myelofibrosis	Myelofibrosis	Secondary Myelofibrosis
C27702	Previously_Treated_Myelodysplastic_Syndrome	Myelodysplastic_Syndrome	Previously Treated Myelodysplastic Syndrome
C27703	C-Myc_Translocation	Chromosomal_Translocation	C-Myc Translocation|C-MycT
C27704	t_8_14	Retired_Concepts	t(8;14)
C27705	t_2_8	Chromosomal_Translocation	t(2;8)(p11;q24)|t(2;8)
C27706	t_8_22	Retired_Concepts	t(8;22)(q24;q11)|t(8;22)
C27707	Virus-Related_Sarcoma	Virus-Related_Malignant_Neoplasm	Virus-Related Sarcoma
C27709	Psammoma_Body_Formation	Calcification	Psammoma Body Formation|psammoma bodies	(sam-O-ma) Structures found in some benign (noncancerous) or malignant (cancerous) tumor cells that look like hardened concentric rings when viewed under a microscope.  Can be a sign of chronic inflammation.
C27710	Pulmonary_Sulcus_Neoplasm	Lung_Neoplasm	Pulmonary Sulcus Neoplasm|Pulmonary Sulcus Tumor|pulmonary sulcus tumor	Non-small cell lung cancer that originates in the upper portion of the lung and extends to other nearby tissues such as the ribs and vertebrae. Also called a Pancoast tumor.
C27711	t_2_5	Chromosomal_Translocation	t(2;5)(p23;q35)|t(2;5)
C27712	_5q-	Chromosomal_Loss	Loss of Chromosome 5q|5q Deletion|5q-|del(5q)
C27713	t_11_18_q21_q21	Chromosomal_Translocation	t(11;18)(q21;q21)|AP12-MLT Translocation
C27714	CCND1_Gene_Rearrangement	Clonal_Gene_Rearrangement	Clonal CCND1 Gene Rearrangement|BCL-1 Rearrangement|CCND1 Gene Rearrangement|Clonal BCL-1 Gene Rearrangement|Monoclonal BCL-1 Gene Rearrangement
C27715	t_1_19_q23_p13_3_PBX_E2A	Chromosomal_Translocation	t(1;19)(q23;p13.3)|t(1;19) (q23;p13.3); PBX/E2A|t(1;19)(q23;p13.3); PBX/E2A
C27716	Extragastrointestinal_Gastrointestinal_Stromal_Tumor	Gastrointestinal_Stromal_Tumor	Extragastrointestinal Gastrointestinal Stromal Tumor|EGIST
C27717	Tubulolobular_Breast_Carcinoma	Retired_Concepts	Tubulolobular Breast Carcinoma
C27718	Human_Papilloma_Virus-Related_Malignant_Neoplasm	Virus-Related_Malignant_Neoplasm	Human Papilloma Virus-Related Malignant Neoplasm|HPV-Related Malignancy|Human Papilloma Virus-Related Malignancy
C27719	Cutaneous_Radiation-Related_Angiosarcoma	Radiation-Related_Angiosarcoma|Skin_Angiosarcoma	Cutaneous Radiation-Related Angiosarcoma|Cutaneous Radiation-Induced Angiosarcoma
C27720	Well-Differentiated_Pancreatic_Endocrine_Neoplasm	Pancreatic_Endocrine_Neoplasm	Well Differentiated Pancreatic Endocrine Tumor|Well Differentiated Islet Cell Neoplasm|Well Differentiated Pancreatic Endocrine Neoplasm	A functioning or non-functioning pancreatic endocrine neoplasm with indolent or uncertain behavior.  It is always confined to the pancreas.  Neoplasms associated with an indolent clinical course do not show evidence of angioinvasion or perineural invasion microscopically, and are always less than 2 cm in diameter.  Neoplasms associated with uncertain behavior are 2 cm or larger in diameter and/or show microscopic evidence of angioinvasion and/or perineural invasion.
C27721	Gastrointestinal_Neuroendocrine_Neoplasm	Gastrointestinal_Neoplasm|Neuroendocrine_Neoplasm	Gastrointestinal Neuroendocrine Neoplasm|Gastrointestinal Neuroendocrine Tumor
C27722	Therapy-Related_Myelodysplastic_Syndrome	Secondary_Myelodysplastic_Syndrome|Therapy-Related_Acute_Myeloid_Leukemia_and_Myelodysplastic_Syndrome	Therapy-Related Myelodysplastic Syndrome|Therapy Related Myelodysplastic Syndrome|Therapy-Related MDS
C27723	Vulvar_Lichen_Sclerosus	Cutaneous_Precancerous_Condition|Lichen_Sclerosus_et_Atrophicus|Vulvar_Dystrophy	Vulvar Lichen Sclerosus
C27724	Psoriasiform_Dermatitis	Dermatitis	Psoriasiform Dermatitis
C27725	Porphyria_Cutanea_Tarda	Dermatitis	Porphyria Cutanea Tarda
C27726	Refractory_Cytopenia_with_Multilineage_Dysplasia_and_Ringed_Sideroblasts	Refractory_Cytopenia_with_Multilineage_Dysplasia	Refractory Cytopenia with Multilineage Dysplasia and Ringed Sideroblasts|RCMD-RS	A myelodysplastic syndrome characterized by bi-cytopenia or pancytopenia, dysplastic changes in 10% or more of the cells in two or more of the myeloid cell lines, and 15% or more ringed sideroblasts in the bone marrow.  (WHO, 2001) -- 2003
C27727	Non-Functioning_Pancreatic_Endocrine_Neoplasm	Pancreatic_Endocrine_Neoplasm	Non-Functioning Pancreatic Endocrine Tumor|Inactive Pancreatic Endocrine Neoplasm|Inactive Pancreatic Endocrine Tumor|Non-Functioning Pancreatic Endocrine Neoplasm|Nonsyndromic Pancreatic Endocrine Neoplasm|Nonsyndromic Pancreatic Endocrine Tumor	A usually malignant pancreatic endocrine neoplasm which may be associated with elevated hormonal levels in the blood or show positive tissue immunologic reaction to hormonal antibodies, but it is not associated with a hormonal syndrome.
C27728	Poorly_Differentiated_Pancreatic_Endocrine_Carcinoma	Pancreatic_Endocrine_Carcinoma	Poorly Differentiated Pancreatic Endocrine Carcinoma|High Grade Pancreatic Neuroendocrine Carcinoma|Pancreatic Small Cell Carcinoma	An uncommon aggressive pancreatic carcinoma, characterized by the presence of nests and sheets of small to intermediate size malignant cells showing endocrine differentiation.
C27729	Atypical_Follicular_Adenoma	Thyroid_Adenoma	Thyroid Gland Atypical Follicular Adenoma|Atypical Follicular Adenoma	A thyroid gland adenoma with increased cellularity and nuclear atypia.  There is no capsular or vascular invasion. The clinical course is benign. (NCI05)
C27730	Childhood_Wilms_Tumor	Childhood_Renal_Neoplasm|Renal_Wilms_Tumor	Childhood Renal Wilms' Tumor|Childhood Renal Wilms Tumor
C27731	Very_Low_Risk_Gastrointestinal_Stromal_Tumor	Gastrointestinal_Stromal_Tumor	Very Low Risk Gastrointestinal Stromal Tumor|VLR GIST
C27732	Very_Low_Risk_Esophageal_Gastrointestinal_Stromal_Tumor	Esophageal_Gastrointestinal_Stromal_Tumor|Very_Low_Risk_Gastrointestinal_Stromal_Tumor	Very Low Risk Esophageal Gastrointestinal Stromal Tumor
C27733	Very_Low_Risk_Gastric_Gastrointestinal_Stromal_Tumor	Gastric_Gastrointestinal_Stromal_Tumor|Very_Low_Risk_Gastrointestinal_Stromal_Tumor	Very Low Risk Gastric Gastrointestinal Stromal Tumor
C27734	Very_Low_Risk_Small_Intestinal_Gastrointestinal_Stromal_Tumor	Small_Intestinal_Gastrointestinal_Stromal_Tumor|Very_Low_Risk_Gastrointestinal_Stromal_Tumor	Very Low Risk Small Intestinal Gastrointestinal Stromal Tumor
C27735	Colorectal_Gastrointestinal_Stromal_Tumor	Colorectal_Neoplasm|Gastrointestinal_Stromal_Tumor_of_the_Gastrointestinal_Tract	Colorectal Gastrointestinal Stromal Tumor|Colorectal GIST
C27736	Very_Low_Risk_Colorectal_Gastrointestinal_Stromal_Tumor	Colorectal_Gastrointestinal_Stromal_Tumor|Very_Low_Risk_Gastrointestinal_Stromal_Tumor	Very Low Risk Colorectal Gastrointestinal Stromal Tumor
C27737	Low_Risk_Colorectal_Gastrointestinal_Stromal_Tumor	Colorectal_Gastrointestinal_Stromal_Tumor|Low_Risk_Gastrointestinal_Stromal_Tumor	Low Risk Colorectal Gastrointestinal Stromal Tumor
C27738	Intermediate_Risk_Colorectal_Gastrointestinal_Stromal_Tumor	Colorectal_Gastrointestinal_Stromal_Tumor|Intermediate_Risk_Gastrointestinal_Stromal_Tumor	Intermediate Risk Colorectal Gastrointestinal Stromal Tumor
C27739	High_Risk_Colorectal_Gastrointestinal_Stromal_Tumor	Colorectal_Gastrointestinal_Stromal_Tumor|High_Risk_Gastrointestinal_Stromal_Tumor	High Risk Colorectal Gastrointestinal Stromal Tumor
C27740	Focal_Active_Colitis	Colitis	Focal Active Colitis
C27741	Thrombohemorrhagic_Event	Non-Neoplastic_Vascular_Disorder	Thrombohemorrhagic Event|thrombohemorrhagic event	A process that involves either a blood clot or bleeding, such as a heart attack or stroke.
C27742	Stage_IIB_Melanoma_of_the_Skin	Stage_II_Melanoma_of_the_Skin	Stage IIB Melanoma of the Skin|Stage IIB Melanoma|Stage IIB Melanoma of Skin|stage IIB melanoma	Melanoma in which the tumor is more than 4 millimeters thick. It has spread through the lower part of the inner layer of skin (dermis) and into subcutaneous (under the skin) tissue, but not to nearby lymph nodes.
C27743	Somnolence_Syndrome	Somnolence|Syndrome	Somnolence Syndrome|somnolence syndrome	(SOM-no-lens) Periods of drowsiness, lethargy, loss of appetite, and irritability in children following radiation therapy treatments to the head.
C27744	Plexopathy	Degenerative_Disorder	Plexopathy|plexopathy	(pleks-AH-pah-thee) A disorder affecting a network of nerves, blood vessels, or lymph vessels.
C27745	Non-Small_Cell_Adenocarcinoma	Adenocarcinoma	Non-Small Cell Adenocarcinoma|Nonsmall Cell Adenocarcinoma|nonsmall cell adenocarcinoma	(ADD-in-o-KAR-sin-O-ma) A type of cancer that begins in the glandular cells that line certain internal organs and most commonly affects the lungs. It is diagnosed by the way the cells appear under a microscope.
C27746	Hypoxic	Hypoxia	Hypoxic|hypoxic	Having too little oxygen.
C27747	Impotent	Retired_Concepts	Impotent|impotent	(IM-po-tent) Unable to have an erection adequate for sexual intercourse.
C27748	t_9_14_p13_q32	Chromosomal_Translocation	t(9;14)(p13;q32)|PAX5-IGH Translocation
C27749	Precancerous_Dermatitis	Cutaneous_Precancerous_Condition	Precancerous Dermatitis|precancerous dermatitis	A skin disease marked by scaly or thickened patches on the skin, and often caused by prolonged exposure to arsenic.  The patches often occur on sunexposed areas of the skin and in older white men.  These patches may become malignant (cancerous).
C27750	Spinal_Degenerative_Disorder	Degenerative_Disorder|Non-Neoplastic_Bone_Disorder	Spinal Degenerative Disorder|Spinal Degenerative Disease
C27751	t_1_14_p22_q32	Chromosomal_Translocation	t(1;14)(p22;q32)
C27752	t_2_18_p12_q21	Chromosomal_Translocation	t(2;18)(p12;q21)
C27753	Acute_Myeloid_Leukemia_not_Otherwise_Categorized	Acute_Myeloid_Leukemia	Acute Myeloid Leukemia not Otherwise Categorized	This category of acute myeloid leukemias is morphology based and reflects the morphologic subtypes present in the French-American-British (FAB) classification scheme.  (WHO, 2001) -- 2003
C27754	Alkylating_Agent-Related_Acute_Myeloid_Leukemia	Alkylating_Agent-Related_Acute_Myeloid_Leukemia_and_Myelodysplastic_Syndrome|Therapy-Related_Acute_Myeloid_Leukemia	Alkylating Agent-Related Acute Myeloid Leukemia|Alkylating Agent Related Acute Myeloid Leukemia|Alkylating Agent-Related AML
C27755	Topoisomerase_II_Inhibitor-Related_Acute_Myeloid_Leukemia	Therapy-Related_Acute_Myeloid_Leukemia	Topoisomerase II Inhibitor-Related Acute Myeloid Leukemia|Topoisomerase II Inhibitor Related Acute Myeloid Leukemia|Topoisomerase II Inhibitor-Related AML
C27756	Typical_Acute_Promyelocytic_Leukemia	Acute_Promyelocytic_Leukemia	Typical Acute Promyelocytic Leukemia|Hypergranular Acute Promyelocytic Leukemia
C27757	Microgranular_Acute_Promyelocytic_Leukemia	Acute_Promyelocytic_Leukemia	Microgranular Acute Promyelocytic Leukemia|Hypogranular Acute Promyelocytic Leukemia
C27758	t_15_17_q22_q12	Chromosomal_Translocation	t(15;17)(q22;q12)
C27759	t_16_16_p13_q22	Chromosomal_Translocation	t(16;16)(p13;q22)
C27760	Bacterium-Related_Malignant_Neoplasm	Infection-Related_Malignant_Neoplasm	Bacterium-Related Malignant Neoplasm|Bacterium-Related Cancer|Bacterium-Related Malignancy
C27761	Helicobacter_Pylori-Related_Malignant_Neoplasm	Bacterium-Related_Malignant_Neoplasm	Helicobacter Pylori-Related Malignant Neoplasm|Helicobacter Pylori-Related Malignancy
C27762	Helicobacter_Pylori-Related_Non-Hodgkin_s_Lymphoma	Helicobacter_Pylori-Related_Malignant_Neoplasm|Non-Hodgkin_s_Lymphoma	Helicobacter Pylori-Related Non-Hodgkin's Lymphoma|Helicobacter Pylori-Related Non-Hodgkin Lymphoma
C27763	Helicobacter_Pylori-Related_Gastric_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Gastric_Mucosa-Associated_Lymphoid_Tissue_Lymphoma|Helicobacter_Pylori-Related_Non-Hodgkin_s_Lymphoma	Helicobacter Pylori-Associated Gastric Mucosa-Associated Lymphoid Tissue Lymphoma|Helicobacter Pylori-Associated Gastric MALT
C27764	Helicobacter_Pylori-Related_Carcinoma	Carcinoma|Helicobacter_Pylori-Related_Malignant_Neoplasm	Helicobacter Pylori-Related Carcinoma
C27765	Helicobacter_Pylori-Related_Gastric_Adenocarcinoma	Helicobacter_Pylori-Related_Carcinoma|Sporadic_Gastric_Carcinoma	Helicobacter Pylori-Related Gastric Adenocarcinoma
C27766	Parasite-Related_Malignant_Neoplasm	Infection-Related_Malignant_Neoplasm	Parasite-Related Malignant Neoplasm|Parasite-Related Cancer|Parasite-Related Malignancy
C27767	Parasite-Related_Carcinoma	Carcinoma|Parasite-Related_Malignant_Neoplasm	Parasite-Related Carcinoma
C27768	Schistosoma_Hematobium-Related_Bladder_Squamous_Cell_Carcinoma	Bladder_Squamous_Cell_Carcinoma|Parasite-Related_Carcinoma	Schistosoma Hematobium-Related Bladder Squamous Cell Carcinoma
C27769	Opisthorchis_Viverrini-Related_Cholangiocarcinoma	Cholangiocarcinoma|Parasite-Related_Carcinoma	Opisthorchis Viverrini-Related Cholangiocarcinoma|Liver Fluke-Related Cholangiocarcinoma|Opisthorchis Viverrini-Related Cholangiocellular Carcinoma
C27770	Immunodeficiency-Related_Malignant_Neoplasm	Immunodeficiency-Related_Neoplasm	Immunodeficiency-Related Malignant Neoplasm|Immunosuppression-Related Cancer|Immunosuppression-Related Malignancy|Immunosuppression-Related Malignant Neoplasm
C27771	Old_Burn_Scar-Related_Neoplasm	Neoplasm_by_Cause	Old Burn Scar-Related Neoplasm
C27772	Cigarette_Smoking-Related_Carcinoma	Tobacco-Related_Carcinoma	Cigarette Smoking-Related Carcinoma
C27773	Tobacco_Chewing-Related_Carcinoma	Tobacco-Related_Carcinoma	Tobacco Chewing-Related Carcinoma
C27774	Asbestos-Related_Malignant_Neoplasm	Occupational_Malignant_Neoplasm	Asbestos-Related Malignant Neoplasm|Asbestos-Related Cancer
C27775	Aromatic_Dyes-Related_Malignant_Neoplasm	Occupational_Malignant_Neoplasm	Aromatic Dyes-Related Malignant Neoplasm|Aromatic Dyes-Related Cancer
C27776	Solar_Radiation-Related_Malignant_Neoplasm	Environment-Related_Malignant_Neoplasm|Radiation-Related_Malignant_Neoplasm	Solar Radiation-Related Malignant Neoplasm|Solar Radiation-Related Cancer
C27777	Giant_Hemangioma	Cavernous_Hemangioma	Giant Hemangioma
C27778	Autoimmune_Hepatitis_with_Centrilobular_Necrosis	Autoimmune_Hepatitis	Autoimmune Hepatitis with Centrilobular Necrosis
C27779	Lymphohistiocytoid_Mesothelioma	Sarcomatoid_Mesothelioma	Lymphohistiocytoid Mesothelioma
C27780	Myelodysplastic_Myeloproliferative_Disease_Unclassifiable	Myelodysplastic_Myeloproliferative_Disease	Myelodysplastic/Myeloproliferative Disease, Unclassifiable|MDS/MPD, U|MDS/MPD-U|Mixed Myelodysplastic/Myeloproliferative Disease, Unclassifiable|Mixed Myeloproliferative/Myelodysplastic Syndrome, Unclassifiable|Unclassifiable Myelodysplastic/Myeloproliferative Disease|Unclassifiable Myeloproliferative/Myelodysplastic Syndrome	This entity includes cases that have clinical, laboratory, and morphologic features that support the diagnosis of both a myelodysplastic syndrome and a chronic myeloproliferative disorder, but do not meet the criteria for any of the other entities included in the myelodysplastic/myeloproliferative disease category.  (WHO, 2001) -- 2003
C27781	Myxoid_Round_Cell_Liposarcoma	Liposarcoma	Myxoid/Round Cell Liposarcoma|Mixed-Type Liposarcoma
C27782	Upper_Extremity_Fracture	Fracture	Upper Extremity Fracture|Upper Limb Fracture
C27783	Arm_Fracture	Upper_Extremity_Fracture	Arm Fracture
C27784	Metastatic_Penile_Cancer	Stage_IV_Penile_Cancer	Metastatic Penile Cancer|Metastatic Carcinoma of Penis|Metastatic Carcinoma of the Penis|Metastatic Penile Carcinoma|Metastatic Penis Cancer|Metastatic Penis Carcinoma	Stage IV includes: (T4, Any N, M0); (Any T, N3, M0); (Any T, Any N, M1).  T4: Tumor invades other adjacent structures.  N3: Metastasis in deep inguinal or pelvic lymph node(s) unilateral or bilateral.  M1: Distant metastasis.  (AJCC 6th ed.) - 2003
C27785	Stage_I_Testicular_Non-Seminomatous_Germ_Cell_Tumor	Malignant_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Stage_I_Testicular_Cancer	Stage I Testicular Non-Seminomatous Germ Cell Tumor|Stage I Testicular Nonseminomatous Germ Cell Tumor
C27786	Stage_II_Testicular_Non-Seminomatous_Germ_Cell_Tumor	Malignant_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Stage_II_Testicular_Cancer	Stage II Testicular Non-Seminomatous Germ Cell Tumor|Stage II Testicular Nonseminomatous Germ Cell Tumor
C27787	Stage_III_Testicular_Non-Seminomatous_Germ_Cell_Tumor	Malignant_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Stage_III_Testicular_Cancer	Stage III Testicular Non-Seminomatous Germ Cell Tumor|Stage III Testicular Nonseminomatous Germ Cell Tumor
C27788	Female_Reproductive_System_Precancerous_Condition	Female_Reproductive_System_Disorder|Precancerous_Condition_by_Site	Female Reproductive System Precancerous Condition
C27789	Endometrial_Intraepithelial_Neoplasia	Endometrial_Neoplasm|Female_Reproductive_System_Precancerous_Condition|Glandular_Cell_Intraepithelial_Neoplasia	Endometrial Intraepithelial Neoplasia|EIN|EmGD|Endometrial Glandular Dysplasia
C27790	Penile_Carcinoma_in_situ	High_Grade_Penile_Intraepithelial_Neoplasia|Skin_Squamous_Cell_Carcinoma_in_situ|Stage_0_Penile_Cancer|Stage_0_Squamous_Cell_Carcinoma	Penile Carcinoma In Situ|Bowen's Disease of Penis|Bowen's Disease of the Penis|Carcinoma in situ of Penis|Carcinoma in situ of the Penis|Erythroplasia of Queyrat|Grade III Penile Intraepithelial Neoplasia|Grade III Squamous Intraepithelial Lesion of Penis|Grade III Squamous Intraepithelial Lesion of the Penis|Queyrat Erythroplasia|Queyrat's Erythroplasia	Stage 0 includes: (Tis, N0, M0) and (Ta, N0, M0).  Tis: Carcinoma in situ.  Ta: Non-invasive verrucous carcinoma.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.) - 2003
C27791	Non-Invasive_Verrucous_Carcinoma_of_the_Penis	Stage_0_Penile_Cancer|Verrucous_Carcinoma_of_the_Penis	Non-Invasive Verrucous Carcinoma of the Penis|Non-Invasive Penile Verrucous Carcinoma|Non-Invasive Verrucous Carcinoma of Penis
C27792	Spindle_Cell_Type_Gastrointestinal_Stromal_Tumor	Gastrointestinal_Stromal_Tumor	Spindle Cell Type Gastrointestinal Stromal Tumor|Spindle Cell Type GIST
C27793	Mixed_Cell_Type_Gastrointestinal_Stromal_Tumor	Gastrointestinal_Stromal_Tumor	Mixed Cell Type Gastrointestinal Stromal Tumor|Mixed Cell Type GIST
C27794	Polycythemia_Excluding_Polycythemia_Vera	Polycythemia	Polycythemia (Excluding Polycythemia Vera)|Polycythemia (Excluding Rubra Vera)
C27795	Urothelial_Transitional_Cell_Carcinoma_with_Glandular_Differentiation	Retired_Concepts	Urothelial (Transitional Cell) Carcinoma with Glandular Differentiation
C27796	Urothelial_Transitional_Cell_Carcinoma_with_Squamous_Differentiation	Retired_Concepts	Urothelial (Transitional Cell) Carcinoma with Squamous Differentiation
C27797	Common_Acute_Lymphoblastic_Leukemia	Leukemia_Antiquated	Common Acute Lymphoblastic Leukemia
C27798	Pre-B_Acute_Lymphoblastic_Leukemia	Leukemia_Antiquated	Pre-B Acute Lymphoblastic Leukemia
C27799	Pre-Pre-B_Acute_Lymphoblastic_Leukemia	Leukemia_Antiquated	Pre-Pre-B Acute Lymphoblastic Leukemia
C27800	Mycosis_Fungoides_Working_Formulation	Lymphoma_by_Working_Formulation_Antiquated	Mycosis Fungoides (Working Formulation)	(mye-KO-sis fun-GOY-deez)
C27801	Non-Neoplastic_Thymus_Disorder	Thymus_Disorder	Non-Neoplastic Thymus Disorder
C27802	Thymic_Dysplasia	Non-Neoplastic_Mediastinal_Disorder|Non-Neoplastic_Thymus_Disorder	Thymic Dysplasia
C27803	Acute_Thymic_Involution	Non-Neoplastic_Mediastinal_Disorder|Non-Neoplastic_Thymus_Disorder	Acute Thymic Involution
C27804	Ectopic_Thymus	Non-Neoplastic_Thymus_Disorder	Ectopic Thymus
C27805	True_Thymic_Hyperplasia	Non-Neoplastic_Mediastinal_Disorder|Non-Neoplastic_Thymus_Disorder	True Thymic Hyperplasia
C27806	Metastatic_Renal_Cell_Cancer	Stage_IV_Renal_Cell_Cancer	Metastatic Renal Cell Cancer|Metastatic Renal Cell Carcinoma	A renal cell cancer that has invaded the renal capsule and has spread to lymph nodes and other anatomic sites.  Metastatic renal cell cancer is stage IV, but stage IV includes some non-metastatic tumors, e.g. T4 M0. --2003
C27807	Hodgkin_s_Disease_Nodular_Sclerosis_Syncytial_Variant	Hodgkin_s_Lymphoma_Antiquated	Hodgkin's Disease, Nodular Sclerosis, Syncytial Variant
C27808	Hodgkin_s_Disease_Nodular_Sclerosis_Lymphocyte_Depletion	Hodgkin_s_Lymphoma_Antiquated	Hodgkin's Disease, Nodular Sclerosis, Lymphocyte Depletion
C27809	Hodgkin_s_Lymphoma_Antiquated	Hematopoietic_and_Lymphoid_Neoplasms_Antiquated	Hodgkin's Lymphoma (Antiquated)
C27810	Malignant_Non-Hodgkin_s_Lymphoma_Cleaved_Cell	Malignant_Lymphoma_by_Cell_Type_Working_Formulation	Malignant Non-Hodgkin's Lymphoma, Cleaved Cell
C27811	Malignant_Non-Hodgkin_s_Lymphoma_Small_Cleaved_Cell	Malignant_Non-Hodgkin_s_Lymphoma_Cleaved_Cell	Malignant Non-Hodgkin's Lymphoma, Small Cleaved Cell
C27812	Hematopoietic_Neoplasm_of_Unclear_Meaning	Retired_Concepts	Hematopoietic Neoplasm of Unclear Meaning
C27813	Bile_Duct_Adenocarcinoma	Adenocarcinoma|Bile_Duct_Carcinoma	Bile Duct Adenocarcinoma
C27814	Bile_Duct_Carcinoma	Bile_Duct_Neoplasm|Carcinoma|Malignant_Hepato-Biliary_Neoplasm	Bile Duct Carcinoma|Bile Duct Cancer	A malignant tumor arising from the epithelium of the intrahepatic or extrahepatic bile duct.  Intrahepatic bile duct carcinomas are adenocarcinomas and are called cholangiocarcinomas.  Extrahepatic bile duct carcinomas are adenocarcinomas, adenosquamous carcinomas, squamous cell carcinomas, small cell carcinomas, or mucoepidermoid carcinomas. -- 2004
C27815	Malignant_Endometrial_Neoplasm	Endometrial_Neoplasm|Malignant_Uterine_Corpus_Neoplasm	Malignant Endometrial Neoplasm	Primary or metastatic malignant neoplasm involving the endometrium (mucous membrane that lines the endometrial cavity).  --2003
C27816	Pigmented_Nevus	Melanocytic_Nevus	Pigmented Nevus	A nevus characterised by the presence of excessive pigment. --2003
C27817	Paget_s_Disease_of_Penis	Extramammary_Paget_s_Disease|Penile_Carcinoma	Paget's Disease of the Penis|Paget's Disease of Penis	A premalignant condition morphologically characterised by the presence of the characteristic Paget's cells in the intraepithelial tissue of the penis.  It presents as a smooth raised reddish area that may or may not be painful. -- 2003
C27818	Metastatic_Neoplasm_of_the_Ureter	Malignant_Ureter_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Neoplasm of the Ureter|Metastatic Neoplasm of Ureter|Ureter Metastatic Malignant Neoplasm	Abnormal malignant growth of cells in the ureter (upper urinary tract)that has progressed to involve other areas of the body.
C27819	Metastatic_Neoplasm_of_the_Urethra	Malignant_Urethral_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Neoplasm of the Urethra|Metastatic Neoplasm of Urethra|Urethra Metastatic Malignant Neoplasm	Abnormal malignant growth of cells in the urethra (lower urinary tract)that has spread either into adjacent tissue or to a distant site.
C27820	Mature_T-ALL	Leukemia_Antiquated	Mature T-ALL
C27821	Malignant_Lymphoma_Convoluted	Malignant_Lymphoma_by_Cell_Type_Working_Formulation	Malignant Lymphoma, Convoluted
C27822	Diffuse_Malignant_Lymphoma	Lymphoma_by_Working_Formulation_Antiquated	Diffuse Malignant Lymphoma
C27823	Malignant_Lymphoma_Large_Cell_Type	Malignant_Lymphoma_by_Cell_Type_Working_Formulation	Malignant Lymphoma, Large Cell Type
C27824	Reticulosarcoma	Hematopoietic_and_Lymphoid_Neoplasms_Antiquated	Reticulosarcoma
C27825	Mucin-Secreting_Carcinoma	Carcinoma	Mucin-Secreting Carcinoma|Mucin-Producing Carcinoma
C27826	AIDS-Related_Lymphoma_by_Working_Formulation	Lymphoma_by_Working_Formulation_Antiquated	AIDS-Related Lymphoma by Working Formulation
C27827	Malignant_Lymphoma_by_Cell_Type_Working_Formulation	Lymphoma_by_Working_Formulation_Antiquated	Malignant Lymphoma by Cell Type (Working Formulation)
C27828	Stage_IIIC_Breast_Cancer	Stage_III_Breast_Cancer	Stage IIIC Breast Cancer|Stage IIIC Breast Carcinoma	Stage IIIC Breast Cancer was added in the 6th Edition AJCC Staging Manual, on the basis of metastasis to the infraclavicular lymph nodes (N3) plus any T, M0.
C27829	Invasive_Breast_Carcinoma_by_Histologic_Grade	Invasive_Breast_Carcinoma	Invasive Breast Carcinoma by Histologic Grade|Infiltrating Breast Carcinoma by Histologic Grade|Infiltrating Breast Carcinoma by Nottingham Combined Histologic Grade|Invasive Breast Carcinoma by Nottingham Combined Histologic Grade
C27830	Grade_1_Invasive_Breast_Carcinoma	Invasive_Breast_Carcinoma_by_Histologic_Grade	Grade 1 Invasive Breast Carcinoma|Favorable Infiltrating Breast Carcinoma|Grade 1 Infiltrating Breast Carcinoma|Low Combined Histologic Grade Infiltrating Breast Carcinoma|Well Differentiated Infiltrating Breast Carcinoma|Well Differentiated Invasive Breast Carcinoma
C27831	Grade_2_Invasive_Breast_Carcinoma	Invasive_Breast_Carcinoma_by_Histologic_Grade	Grade 2 Invasive Breast Carcinoma|Grade 2 Infiltrating Breast Carcinoma|Intermediate Combined Histologic Grade Infiltrating Breast Carcinoma|Moderately Differentiated Infiltrating Breast Carcinoma|Moderately Differentiated Invasive Breast Carcinoma|Moderately Favorable Infiltrating Breast Carcinoma
C27832	Grade_3_Invasive_Breast_Carcinoma	Invasive_Breast_Carcinoma_by_Histologic_Grade	Grade 3 Invasive Breast Carcinoma|Grade 3 Infiltrating Breast Carcinoma|High Combined Histologic Grade Infiltrating Breast Carcinoma|Poorly Differentiated Infiltrating Breast Carcinoma|Poorly Differentiated Invasive Breast Carcinoma|Unfavorable Infiltrating Breast Carcinoma
C27833	Dysplasia_in_Barrett_s_Esophagus	Dysplasia	Dysplasia in Barrett's Esophagus
C27834	Low-Grade_Dysplasia_in_Barrett_s_Esophagus	Dysplasia_in_Barrett_s_Esophagus	Low Grade Dysplasia in Barrett's Esophagus
C27835	High-Grade_Dysplasia_in_Barrett_s_Esophagus	Dysplasia_in_Barrett_s_Esophagus	High Grade Dysplasia in Barrett's Esophagus
C27836	Persistent_Superficial_Gastritis	Gastric_Precancerous_Condition|Gastritis	Persistent Superficial Gastritis	This is a condition that predisposes to gastric mucosa-associated lymphoid tissue lymphoma. --2003
C27837	Gastritis_Associated_with_Crohn_s_Disease	Gastritis	Gastritis Associated with Crohn's Disease|Crohn's Associated Gastritis
C27838	Uterine_Serous_Carcinoma	Serous_Adenocarcinoma|Type_II_Endometrial_Adenocarcinoma	Endometrial Serous Adenocarcinoma|Uterine Corpus Serous Adenocarcinoma
C27839	Uterine_Corpus_Endometrioid_Adenocarcinoma_Secretory_Variant	Uterine_Corpus_Endometrioid_Adenocarcinoma	Endometrial Endometrioid Adenocarcinoma, Secretory Variant|Secretory Uterine Corpus Endometrioid Adenocarcinoma
C27840	Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Papillae	Uterine_Corpus_Endometrioid_Adenocarcinoma	Endometrial Endometrioid Adenocarcinoma with Papillae
C27841	Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Small_Glands_Tubules_or_Cords	Uterine_Corpus_Endometrioid_Adenocarcinoma	Endometrial Endometrioid Adenocarcinoma with Small Glands, Tubules or Cords
C27842	Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Metaplastic_Changes	Uterine_Corpus_Endometrioid_Adenocarcinoma	Endometrial Endometrioid Adenocarcinoma with Metaplastic Changes
C27843	Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Clear_Cell_Change	Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Metaplastic_Changes	Endometrial Endometrioid Adenocarcinoma with Clear Cell Change	A morphologic variant of endometrioid adenocarcinoma characterized by the presence of large multinucleated clear cells.
C27844	Uterine_Corpus_Endometrioid_Adenocarcinoma_with_a_Poorly_Differentiated_Carcinomatous_Component	Uterine_Corpus_Endometrioid_Adenocarcinoma	Endometrial Endometrioid Adenocarcinoma with a Poorly Differentiated Carcinomatous Component
C27845	Uterine_Corpus_Endometrioid_Adenocarcinoma_with_an_Undifferentiated_Carcinomatous_Component	Uterine_Corpus_Endometrioid_Adenocarcinoma	Endometrial Endometrioid Adenocarcinoma with an Undifferentiated Carcinomatous Component
C27846	Villoglandular_Uterine_Corpus_Endometrioid_Adenocarcinoma	Uterine_Corpus_Endometrioid_Adenocarcinoma	Villoglandular Endometrial Endometrioid Adenocarcinoma
C27847	Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Small_Nonvillous_Papillae	Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Papillae	Endometrial Endometrioid Adenocarcinoma with Small Nonvillous Papillae
C27848	Uterine_Corpus_Endometrioid_Adenocarcinoma_Ciliated_Variant	Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Metaplastic_Changes	Endometrial Endometrioid Adenocarcinoma, Ciliated Variant|Ciliated Uterine Corpus Endometrioid Adenocarcinoma
C27849	Oxyphilic_Uterine_Corpus_Endometrioid_Adenocarcinoma	Oxyphilic_Adenocarcinoma|Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Metaplastic_Changes	Oxyphilic Endometrial Endometrioid Adenocarcinoma
C27850	Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Spindled_Epithelial_Cells	Uterine_Corpus_Endometrioid_Adenocarcinoma_with_Metaplastic_Changes	Endometrial Endometrioid Adenocarcinoma with Spindled Epithelial Cells|Sarcomatoid Uterine Corpus Endometrioid Adenocarcinoma
C27851	Human_Papilloma_Virus_Infection	Viral_Infection	Human Papilloma Virus Infection
C27852	AIDS-Related_Human_Papilloma_Virus_Infection	Human_Papilloma_Virus_Infection	AIDS-Related Human Papilloma Virus Infection
C27853	Angiofollicular_Lymphoid_Hyperplasia_Hyaline-Vascular_Type	Angiofollicular_Lymphoid_Hyperplasia	Angiofollicular Lymphoid Hyperplasia, Hyaline-Vascular Type|Castleman's Disease, Hyaline-Vascular Type
C27854	Angiofollicular_Lymphoid_Hyperplasia_Plasma_Cell_Type	Angiofollicular_Lymphoid_Hyperplasia	Angiofollicular Lymphoid Hyperplasia, Plasma Cell Type|Castleman's Disease, Plasma Cell Type
C27855	Multicentric_Angiofollicular_Lymphoid_Hyperplasia	Angiofollicular_Lymphoid_Hyperplasia	Multicentric Angiofollicular Lymphoid Hyperplasia|Multicentric Castleman's Disease
C27856	Kaposi_s_Sarcoma-Associated_Human_Herpes_Virus_8_Positive_Extracavity_Lymphoma	Human_Herpes_Virus_8-Related_Malignant_Neoplasm|Plasmablastic_Lymphoma|Virus-Related_Lymphoma	Kaposi's Sarcoma-Associated Human Herpes Virus 8 Positive Extracavity Lymphoma|KSHV-8 Positive Extracavity Lymphoma|KSHV-8+ Extracavity Lymphoma|Kaposi's Sarcoma-Associated Human Herpes Virus 8+ Extracavity Lymphoma	This recently described type of plasmablastic B-cell lymphoma occurs primarily in patients with Kaposi's Sarcoma Herpes virus 8-related angiofollicular hyperplasia (Castleman's disease) of the multicentric type.  It has also been described in HIV+ patients and is related to the primary effusion lymphoma as well. --2003
C27857	V-ABL_Gene	Burkitt_s_Lymphoma_with_Plasmacytoid_Differentiation|ENV_Gene	AIDS-Related Burkitt's Lymphoma with Plasmacytoid Differentiation
C27858	AIDS-Related_Kaposi_s_Sarcoma-Associated_Human_Herpes_Virus_8_Positive_Extracavity_Lymphoma	AIDS-Related_Plasmablastic_Lymphoma|Kaposi_s_Sarcoma-Associated_Human_Herpes_Virus_8_Positive_Extracavity_Lymphoma	AIDS-Related Kaposi's Sarcoma-Associated Human Herpes Virus 8 Positive Extracavity Lymphoma
C27859	AIDS-Related_Plasmablastic_Lymphoma	AIDS-Related_Diffuse_Large_B-cell_Lymphoma|Plasmablastic_Lymphoma	AIDS-Related Plasmablastic Lymphoma
C27860	AIDS-Related_Vulvovaginal_Candidiasis	Diseases_Associated_with_AIDS|Vulvovaginal_Candidiasis	AIDS-Related Vulvovaginal Candidiasis
C27861	AIDS-Related_Cryptococcosis	Cryptococcosis|Diseases_Associated_with_AIDS	AIDS-Related Cryptococcosis
C27862	AIDS-Related_Herpes_Zoster	Diseases_Associated_with_AIDS	AIDS-Related Herpes Zoster
C27863	AIDS-Related_Pneumocystis_Carinii_Pneumonia	Diseases_Associated_with_AIDS|Pneumocystis_Carinii_Pneumonia	AIDS-Related Pneumocystis Carinii Pneumonia
C27864	Parasitic_Infection	Infectious_Disorder	Parasitic Infection	A successful invasion of a host by an organism that uses the host for food and shelter. (On-Line Medical Dictionary)
C27865	AIDS-Related_Toxoplasmosis	Diseases_Associated_with_AIDS|Toxoplasmosis	AIDS-Related Toxoplasmosis
C27866	AIDS-Related_Pelvic_Inflammatory_Disease	Diseases_Associated_with_AIDS|Pelvic_Inflammatory_Disease	AIDS-Related Pelvic Inflammatory Disease
C27867	AIDS-Related_Oropharyngeal_Candidiasis	Diseases_Associated_with_AIDS|Oropharyngeal_Candidiasis	AIDS-Related Oropharyngeal Candidiasis
C27868	AIDS-Related_Isosporiasis	Diseases_Associated_with_AIDS|Isosporiasis	AIDS-Related Isosporiasis
C27869	AIDS-Related_Idiopathic_Thrombocytopenic_Purpura	Diseases_Associated_with_AIDS|Idiopathic_Thrombocytopenic_Purpura	AIDS-Related Idiopathic Thrombocytopenic Purpura
C27870	Selective_Immunoglobulin_Isotype_Deficiency	Deficiency_of_Humoral_Immunity	Selective Immunoglobulin Isotype Deficiency
C27871	Congenital_Combined_Immunodeficiency	Genetic_Disorder|Immunodeficiency_Syndrome	Congenital Combined Immunodeficiency
C27872	Congenital_T-Cell_Immunodeficiency	Genetic_Disorder|T-Cell_Immunodeficiency	Congenital T-Cell Immunodeficiency
C27873	Congenital_Disorder_of_Natural_Immunity	Genetic_Disorder|Immunodeficiency_Syndrome	Congenital Disorder of Natural Immunity
C27874	Leukocyte_Adhesion_Deficiency	Congenital_Disorder_of_Natural_Immunity	Leukocyte Adhesion Deficiency
C27875	Low-Grade_Papillary_Urothelial_Carcinoma	Stage_0a_Bladder_Cancer	Non-Invasive Bladder Papillary Urothelial Carcinoma, Low Grade	A papillary transitional cell carcinoma of the urinary bladder, characterized by minimal cytologic atypia and infrequent mitotic figures (usually limited to the lower half of the tumor).  This type of carcinoma recurs frequently, may invade the bladder wall, and has a low risk of progression. -- 2003
C27876	High-Grade_Papillary_Urothelial_Carcinoma	Stage_0a_Bladder_Cancer	Non-Invasive Bladder Papillary Urothelial Carcinoma, High Grade	A papillary transitional cell carcinoma of the urinary bladder, characterized by marked architectural and cytologic abnormalities and frequent mitotic figures (at all levels of the urothelium).  This type of carcinoma is commonly associated with invasive disease at the time of presentation. -- 2003
C27877	Urothelial_Hyperplasia	Hyperplasia	Urothelial Hyperplasia	Hyperplasia of the transitional epithelium of the urinary tract.  Morphologically it is subdivided into flat and papillary hyperplasia. -- 2003
C27878	Flat_Urothelial_Hyperplasia	Urothelial_Hyperplasia	Flat Urothelial Hyperplasia	A type of hyperplasia that is characterized by a marked thickening of the urinary tract epithelium.  There is no evidence of cytologic atypia. -- 2003
C27879	Papillary_Urothelial_Hyperplasia	Urinary_Tract_Precancerous_Condition|Urothelial_Hyperplasia	Papillary Urothelial Hyperplasia	A type of hyperplasia that is characterized by variable thickening of the urinary tract epithelium and a slight papillary growth.  The latter is not associated with the presence of fibrovascular cores.  There is no evidence of atypia.  The relationship between this lesion and papillary urothelial neoplasia is not clear. -- 2003
C27880	Intraurothelial_Neoplasia	Non-Invasive_Urothelial_Neoplasm|Transitional_Cell_Intraepithelial_Neoplasia	Intraurothelial Neoplasia	Neoplastic changes in the urinary tract transitional cell epithelium, characterized by cytologic and architectural abnormalities involving part or the entire thickness of the urothelium.  It is classified as either low-grade or high-grade. -- 2003
C27881	Transitional_Cell_Intraepithelial_Neoplasia	Intraepithelial_Neoplasia|Transitional_Cell_Neoplasm	Transitional Cell Intraepithelial Neoplasia
C27882	Low-Grade_Intraurothelial_Neoplasia	Bladder_Flat_Intraepithelial_Lesion|Low_Grade_Intraepithelial_Neoplasia	Bladder Low Grade Intraurothelial Neoplasia|Low-Grade Bladder Intraurothelial Neoplasia	Intraurothelial neoplasia characterized by dysplastic changes which are not severe enough to warrant the diagnosis of bladder carcinoma in situ. -- 2003
C27883	Papillary_Urothelial_Neoplasm	Papillary_Epithelial_Neoplasm|Urothelial_Neoplasm	Papillary Urothelial Neoplasm|Papillary Transitional Cell Neoplasm of the Urinary Tract|Urinary Tract Papillary Transitional Cell Neoplasm	A neoplastic lesion of the urinary tract transitional cell epithelium characterized by papillary formations. -- 2003
C27884	Papillary_Urothelial_Neoplasm_of_Low_Malignant_Potential	Intraurothelial_Neoplasia|Non-Invasive_Bladder_Papillary_Urothelial_Neoplasm	Bladder Papillary Urothelial Neoplasm of Low Malignant Potential|Bladder PUNLMP|Bladder Papillary Neoplasm of Low Malignant Potential|Bladder Papillary Transitional Cell Neoplasm of Low Malignant Potential	A papillary neoplasm of the urinary bladder in which the transitional cells form papillae.  The papillary structures exhibit minimal architectural distortion and minimal atypia.  Mitoses are infrequent.  Patients are at an increased risk of developing new papillary lesions.  Occasionally, the new lesions are urothelial carcinomas. -- 2003
C27885	Invasive_Urothelial_Transitional_Cell_Carcinoma	Bladder_Urothelial_Carcinoma|Infiltrating_Urothelial_Carcinoma	Infiltrating Bladder Urothelial Carcinoma|Infiltrating Transitional Cell Carcinoma of the Urinary Bladder|Invasive Bladder Transitional Cell Carcinoma|Invasive Bladder Urothelial Carcinoma|Invasive Transitional Cell Carcinoma of the Urinary Bladder
C27886	Type_1_Papillary_Renal_Cell_Carcinoma	Sporadic_Papillary_Renal_Cell_Carcinoma	Type 1 Papillary Renal Cell Carcinoma
C27887	Type_2_Papillary_Renal_Cell_Carcinoma	Sporadic_Papillary_Renal_Cell_Carcinoma	Type 2 Papillary Renal Cell Carcinoma
C27888	Classic_Variant_of_Chromophobe_Renal_Cell_Carcinoma	Chromophobe_Renal_Cell_Carcinoma	Classic Variant of Chromophobe Renal Cell Carcinoma
C27889	Eosinophilic_Variant_of_Chromophobe_Renal_Cell_Carcinoma	Chromophobe_Renal_Cell_Carcinoma	Eosinophilic Variant of Chromophobe Renal Cell Carcinoma
C27890	Sporadic_Papillary_Renal_Cell_Carcinoma	Papillary_Renal_Cell_Carcinoma	Sporadic Papillary Renal Cell Carcinoma
C27891	Xp11_Translocation-Related_Renal_Cell_Carcinoma	Renal_Cell_Carcinoma	Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions|Xp11.2 Translocation-Related Renal Cell Carcinoma	A renal cell carcinoma, usually papillary, affecting younger patients.  It is associated with a translocation involving breakpoint at Xp11.2. --2003
C27892	Unclassified_Renal_Cell_Carcinoma	Renal_Cell_Carcinoma	Unclassified Renal Cell Carcinoma	An aggressive renal cell carcinoma.  It usually presents as a large tumor mass, and often has a poor clinical outcome. -- 2003
C27893	Sarcomatoid_Renal_Cell_Carcinoma	Renal_Cell_Carcinoma|Sarcomatoid_Carcinoma	Sarcomatoid Renal Cell Carcinoma	A high grade carcinoma of the kidney.  It is not a distinct clinicopathological entity and includes a diverse group of renal cell carcinomas which have been transformed from a lower to a higher grade. -- 2003
C27894	Carotenosis_Cutis	Skin_Discoloration	Carotenosis Cutis
C27895	Laboratory_and_Clinical_Finding	Retired_Concepts	Laboratory and Clinical Finding
C27896	Multicentric_Reticulohistiocytosis	Benign_Fibrohistiocytic_Neoplasm	Multicentric Reticulohistiocytosis	A systemic disease, often associated with arthritis, fever, and weight loss.  The cutaneous lesions consist of histiocytes, which are usually confined to the dermis.  A large number of patients develop malignant tumors (carcinomas, sarcomas, and lymphomas). --2003
C27897	T-Cell_Proliferation_of_Uncertain_Malignant_Potential	Mature_T-Cell_and_NK-Cell_Neoplasm|Neoplasm_of_Uncertain_Malignant_Potential|Premalignant_Hematologic_Condition	T-Cell Proliferation of Uncertain Malignant Potential
C27898	Recurrent_Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor	Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor|Recurrent_Primitive_Neuroectodermal_Tumor	Recurrent Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Recurrent Tumors of Ewing's Family|Recurrent Tumors of the Ewing's Family
C27899	Recurrent_Peripheral_Primitive_Neuroectodermal_Tumor	Peripheral_Primitive_Neuroectodermal_Tumor|Recurrent_Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor	Recurrent Peripheral Primitive Neuroectodermal Tumor
C27900	Recurrent_Askin_s_Tumor	Askin_s_Tumor|Recurrent_Peripheral_Primitive_Neuroectodermal_Tumor	Recurrent Askin's Tumor
C27901	Localized_Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor	Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor|Localized_Primitive_Neuroectodermal_Tumor	Localized Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor|Localized Tumors of Ewing's Family|Localized Tumors of the Ewing's Family
C27902	Localized_Askin_s_Tumor	Askin_s_Tumor|Localized_Peripheral_Primitive_Neuroectodermal_Tumor	Localized Askin's Tumor
C27903	Localized_Peripheral_Primitive_Neuroectodermal_Tumor	Localized_Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor|Peripheral_Primitive_Neuroectodermal_Tumor	Localized Peripheral Primitive Neuroectodermal Tumor
C27904	Retroperitoneal_Leiomyosarcoma	Leiomyosarcoma	Retroperitoneal Leiomyosarcoma	A highly aggressive leiomyosarcoma, predominantly affecting females. -- 2003
C27905	Well_Differentiated_Prostate_Adenocarcinoma	Prostate_Adenocarcinoma	Well Differentiated Prostate Adenocarcinoma
C27906	Moderately_Differentiated_Prostate_Adenocarcinoma	Prostate_Adenocarcinoma	Moderately Differentiated Prostate Adenocarcinoma
C27907	B-Cell_Lymphocytic_Neoplasm	Lymphocytic_Neoplasm	B-Cell Neoplasm|B-Cell Lymphocytic Neoplasm
C27908	T-Cell_and_NK-Cell_Neoplasm	Lymphocytic_Neoplasm	T-Cell and NK-Cell Neoplasm|T-Cell Neoplasm
C27909	Mature_T-Cell_and_NK-Cell_Neoplasm	T-Cell_and_NK-Cell_Neoplasm	Mature T-Cell and NK-Cell Neoplasm|Mature T-Cell Neoplasm	A group of neoplasms composed of T-lymphocytes with a mature (peripheral/post-thymic) immunophenotypic profile and/or NK-cells.  This group of neoplasms is more frequently seen in Asians, and generally has an aggressive clinical course.--2004
C27910	Mature_B-Cell_Lymphocytic_Neoplasm	B-Cell_Lymphocytic_Neoplasm	Mature B-Cell Neoplasm|Mature B-Cell Lymphocytic Neoplasm
C27911	Chronic_Lymphocytic_Leukemia_Small_Lymphocytic_Lymphoma	Mature_B-Cell_Lymphocytic_Neoplasm	Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma|CLL/SLL
C27912	Therapy-Related_Acute_Myeloid_Leukemia_and_Myelodysplastic_Syndrome	Myeloid_Neoplasm	Therapy-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome|Acute Myeloid Leukaemias and Myelodysplastic Syndromes, Therapy-Related|Therapy-Related AML and MDS
C27913	Alkylating_Agent-Related_Acute_Myeloid_Leukemia_and_Myelodysplastic_Syndrome	Therapy-Related_Acute_Myeloid_Leukemia_and_Myelodysplastic_Syndrome	Alkylating Agent-Related Acute Myeloid Leukemia and Myelodysplastic Syndrome|Alkylating Agent Related Acute Myeloid Leukemia and Myelodysplastic Syndrome|Alkylating Agent-Related AML and MDS
C27914	Sporadic_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma	Sporadic Burkitt's Lymphoma|Sporadic Burkitt Lymphoma
C27915	Immunodeficiency-Related_Burkitt_s_Lymphoma	Burkitt_s_Lymphoma	Immunodeficiency-Related Burkitt's Lymphoma|Immunodeficiency Associated Burkitt Lymphoma|Immunodeficiency Associated Burkitt's Lymphoma|Immunodeficiency Related Burkitt Lymphoma|Immunodeficiency Related Burkitt's Lymphoma|Immunodeficiency-Associated Burkitt Lymphoma|Immunodeficiency-Associated Burkitt's Lymphoma|Immunodeficiency-Related Burkitt Lymphoma
C27916	Poorly_Differentiated_Prostate_Adenocarcinoma	Prostate_Adenocarcinoma	Poorly Differentiated Prostate Adenocarcinoma
C27917	Lymphocytic_and_Plasma_Cell_Neoplasm	Retired_Concepts	Lymphocytic and Plasma Cell Neoplasm|Lymphocytic and Plasma Cell Tumor|Lymphocytic and Plasma Cell Tumour|Lymphocytic and Plasmacytic Neoplasm|Lymphoid and Plasma Cell Tumor|Lymphoid and Plasma Cell Tumour|Lymphoid and Plasmacytic Neoplasm|Lymphoid and Plasmacytic Tumor|Lymphoid and Plasmacytic Tumour
C27918	Old_Burn_Scar-Related_Skin_Squamous_Cell_Carcinoma	Old_Burn_Scar-Related_Neoplasm|Skin_Squamous_Cell_Carcinoma	Old Burn Scar-Related Skin Squamous Cell Carcinoma|Old Burn Scar-Related Squamous Cell Carcinoma of Skin|Old Burn Scar-Related Squamous Cell Carcinoma of the Skin
C27919	Old_Burn_Scar-Related_Melanoma_of_the_Skin	Cutaneous_Melanoma|Old_Burn_Scar-Related_Neoplasm	Old Burn Scar-Related Skin Melanoma|Old Burn Scar-Related Melanoma of Skin|Old Burn Scar-Related Melanoma of the Skin
C27920	Solar_Radiation-Related_Melanoma_of_the_Skin	Cutaneous_Melanoma|Solar_Radiation-Related_Malignant_Neoplasm	Solar Radiation-Related Skin Melanoma|Solar Radiation-Related Melanoma of Skin|Solar Radiation-Related Melanoma of the Skin
C27921	Solar_Radiation-Related_Skin_Squamous_Cell_Carcinoma	Skin_Squamous_Cell_Carcinoma|Solar_Radiation-Related_Malignant_Neoplasm	Solar Radiation-Related Skin Squamous Cell Carcinoma
C27922	Aflatoxins-Related_Hepatocellular_Carcinoma	Environment-Related_Malignant_Neoplasm|Hepatocellular_Carcinoma	Aflatoxins-Related Hepatocellular Carcinoma
C27923	Lifestyle-Related_Neoplasm	Retired_Concepts	Lifestyle-Related Neoplasm|Behavior-Related Neoplasm|Behaviour-Related Neoplasm
C27924	Alcohol-Related_Hepatocellular_Carcinoma	Alcohol-Related_Carcinoma|Hepatocellular_Carcinoma	Alcohol-Related Hepatocellular Carcinoma
C27925	Asbestos-Related_Lung_Carcinoma	Asbestos-Related_Malignant_Neoplasm|Lung_Carcinoma	Asbestos-Related Lung Carcinoma	A carcinoma arising in the lung due to exposure to asbestos. (NCI05)
C27926	Asbestos-Related_Malignant_Mesothelioma	Asbestos-Related_Malignant_Neoplasm|Malignant_Mesothelioma	Asbestos-Related Malignant Mesothelioma
C27927	Alcohol-Related_Carcinoma	Behavior-Related_Disorder|Carcinoma|Neoplasm_by_Cause	Alcohol-Related Carcinoma
C27928	Alcohol-Related_Esophageal_Carcinoma	Alcohol-Related_Carcinoma|Esophageal_Carcinoma	Alcohol-Related Esophageal Carcinoma
C27929	Alcohol-Related_Laryngeal_Carcinoma	Alcohol-Related_Carcinoma|Laryngeal_Carcinoma	Alcohol-Related Laryngeal Carcinoma
C27930	Ionizing_Radiation-Related_Malignant_Neoplasm	Occupational_Malignant_Neoplasm|Radiation-Related_Malignant_Neoplasm	Ionizing Radiation-Related Malignant Neoplasm
C27931	Benzene-Related_Acute_Myeloid_Leukemia	Occupational_Malignant_Neoplasm|Secondary_Acute_Myeloid_Leukemia	Benzene-Related Acute Myeloid Leukemia
C27932	Radiation-Induced_Pneumonitis	Radiation-Induced_Abnormalities	Radiation-Induced Pneumonitis
C27933	Neoplasm_by_Cause	Neoplasm_by_Special_Category	Neoplasm by Cause|Neoplasm by Etiology
C27934	Radiation-Related_Disorder	Retired_Concepts	Radiation-Related Disorder|Radiation-Induced Abnormality
C27935	Occupational_Neoplasm	Neoplasm_by_Cause	Occupational Neoplasm
C27936	Immunodeficiency-Related_Neoplasm	Immunodeficiency-Related_Disorder|Neoplasm_by_Cause	Immunodeficiency-Related Neoplasm|Immunosuppression-Related Neoplasm
C27937	Papillary_Thymic_Carcinoma	Papillary_Adenocarcinoma|Thymic_Adenocarcinoma	Thymic Papillary Adenocarcinoma|Papillary Carcinoma of Thymus|Papillary Carcinoma of the Thymus|Thymic Papillary Carcinoma|Thymus Papillary Carcinoma	A rare primary thymic adenocarcinoma, characterized by a papillary growth pattern.  There are only a few published cases, and no good data regarding prognosis. -- 2005
C27938	Combined_Thymoma	Retired_Concepts	Combined Thymoma
C27939	Lobular_Neoplasia	Breast_Neoplasm	Lobular Neoplasia|LIN|LN|Lobular Intraepithelial Neoplasia	(LOB-yoo-lar kar-sin-O-ma in SYE-too) LCIS. Abnormal cells found in the lobules of the breast. This condition seldom becomes invasive cancer; however, having lobular carcinoma in situ increases one's risk of developing breast cancer in either breast.
C27940	Gastrointestinal_Autonomic_Nerve_Tumor	Autonomic_Nervous_System_Neoplasm|Gastrointestinal_Neuroendocrine_Neoplasm	Gastrointestinal Autonomic Nerve Tumor|GANT	Benign and malignant neoplasms which arise from or directly involve components of the autonomic nervous system which innervate the stomach and/or intestines.
C27941	Usual_Ductal_Breast_Hyperplasia	Ductal_Breast_Hyperplasia|Mammary_Intraepithelial_Neoplasia_Ductal_Type	Usual Ductal Breast Hyperplasia|Ductal Breast Hyperplasia of Usual Type|Ordinary Intraductal Breast Hyperplasia|UDH
C27942	Mammary_Intraepithelial_Neoplasia_Ductal_Type	Glandular_Cell_Intraepithelial_Neoplasia|Intraductal_Breast_Neoplasm	Intraductal Proliferative Lesion of the Breast|DIN|Ductal Intraepithelial Neoplasia|Intraductal Proliferative Lesion|Mammary Intraepithelial Neoplasia, Ductal Type
C27943	Solitary_Intraductal_Breast_Papilloma	Intraductal_Breast_Papilloma	Solitary Intraductal Breast Papilloma|Central Breast Papilloma
C27944	Sclerosing_Breast_Papilloma	Intraductal_Breast_Papilloma	Sclerosing Breast Papilloma
C27945	Ductal_Adenoma	Adenoma	Ductal Adenoma
C27946	Multiple_Breast_Papillomas	Retired_Concepts	Multiple Breast Papillomas|Peripheral Breast Papillomas
C27947	Radiation_Anemia	Anemia|Radiation-Induced_Abnormalities	Radiation Anemia
C27948	Tuberculous_Bronchopneumonia	Lung_Tuberculosis	Tuberculous Bronchopneumonia
C27949	Metaplastic_Carcinoma	Carcinoma	Metaplastic Carcinoma|metaplastic carcinoma	A general term used to describe cancer that begins in cells that have changed into another cell type (for example, a squamous cell of the esophagus changing to resemble a cell of the stomach).  In some cases, metaplastic changes alone may mean there is an increased chance of cancer developing at the site.
C27950	Secretory_Carcinoma	Adenocarcinoma	Secretory Carcinoma
C27951	Lymphoma_by_Lukes-Collins_Classification_Antiquated	Hematopoietic_and_Lymphoid_Neoplasms_Antiquated	Lymphoma by Lukes-Collins Classification (Antiquated)
C27952	Senile_Sebaceous_Hyperplasia	Sebaceous_Hyperplasia	Senile Sebaceous Hyperplasia
C27953	Asymmetric_Motor_Neuropathy	Peripheral_Motor_Neuropathy	Asymmetric Motor Neuropathy
C27954	Adolescent	Age_Group	Adolescent|Adolescents	A juvenile between the onset of puberty and maturity; in the state of development between puberty and maturity.
C27955	Drug_Toxicity	Toxicity	Drug Toxicity|toxicity, drug	An adverse effect of a drug used therapeutically or diagnostically. --2004
C27956	Infant	Age_Group	Infant
C27957	Pedigree	Properties_or_Attributes	Pedigree|Genealogical Tree|pedigree	A record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition. (from MeSH)
C27958	Nasal	Anatomy_Modifier	Nasal|nasal	By or having to do with the nose.
C27959	Prostatic	Anatomy_Modifier	Prostatic	Of, or pertaining to, the prostate.
C27960	Personality_Traits	Retired_Concepts	Personality Traits	The characteristics in behavior that a certain person has.
C27961	Neurotoxicity	Toxicity	Neurotoxicity|neurotoxicity	The tendency of some treatments to cause damage to the nervous system.
C27962	Radiation_Toxicity	Toxicity	Radiation Toxicity|toxicity, radiation
C27963	Lytic	Disease_Laboratory_Finding_Modifier	Lytic|lytic	Having to do with lysis. In biology, lysis refers to the disintegration of a cell by disruption of its plasma membrane. Lysis can be caused by chemical or physical means (e.g., high-energy sound waves) or by a virus infection.
C27964	Stage_0a	Stage_0	Stage 0a
C27965	Stage_0is	Stage_0	Stage 0is
C27966	Stage_I	Disease_Stage_Modifier	Stage I|Stage 1
C27967	Stage_IIA	Stage_II	Stage IIA
C27968	Stage_IIB	Stage_II	Stage IIB
C27969	Stage_IIC	Stage_II	Stage IIC
C27970	Stage_III	Disease_Stage_Modifier	Stage III|Stage 3
C27971	Stage_IV	Disease_Stage_Modifier	Stage IV|Stage 4
C27972	Stage_IVS	Stage_IV	Stage IVS
C27973	Stage_V	Disease_Stage_Modifier	Stage V|Stage 5
C27974	Intramuscular	Anatomy_Modifier	Intramuscular|IM|intramuscular	IM.  Within or into muscle.
C27975	Stage_IA	Stage_I	Stage IA
C27976	Stage_IB	Stage_I	Stage IB
C27977	Stage_IIIA	Stage_III	Stage IIIA
C27978	Stage_IIIB	Stage_III	Stage IIIB
C27979	Stage_IVA	Stage_IV	Stage IVA
C27980	Stage_IVB	Stage_IV	Stage IVB
C27981	Stage_IC	Stage_I	Stage IC
C27982	Stage_IIIC	Stage_III	Stage IIIC
C27983	Stage_IA1	Stage_IA	Stage IA1
C27984	Stage_IA2	Stage_IA	Stage IA2
C27985	Viral	General_Modifier	Viral|viral	Having to do with a virus.
C27986	Ultraviolet_A_radiation	Ultraviolet_Radiation	Ultraviolet A Radiation|UVA Radiation|UVA radiation	A type of ultraviolet (UV) radiation. UV rays are invisible rays that are part of the energy that comes from the sun. UVA radiation also comes from sun lamps and tanning beds. Scientists think that UVA radiation may cause skin damage that can lead to skin cancer and premature aging. For this reason, skin specialists recommend that people use sunscreens that reflect, absorb, or scatter ultraviolet radiation.
C27987	Ultraviolet_B_Radiation	Ultraviolet_Radiation	Ultraviolet B Radiation|UVB|UVB Radiation|UVB radiation|Ultraviolet-B Radiation	A type of ultraviolet (UV) radiation. UV rays are invisible rays that are part of the energy that comes from the sun. UVB radiation causes sunburn, and scientists have long thought that it can cause melanoma and other types of skin cancer. Skin specialists recommend that people use sunscreens that reflect, absorb, or scatter ultraviolet radiation.
C27988	Cytotoxicity	Toxicity	Cytotoxicity|Lytotoxicity	The adverse effect of some iatrogenic therapies. It is an accepted side effect in radiation therapy where the desired effect is to kill rapidly growing tumor cells.  In the killing of tumor cells, other cells that are rapidly growing e.g hair, mucous membranes are also killed.
C27989	Physical_Property	Retired_Concepts	Physical Property
C27990	Toxicity	Injury	Toxicity|TOX	The degree to which something is poisonous.
C27991	Intrathecal	Retired_Concepts	Intrathecal|intrathecal
C27992	Disease_Modifier	Qualifier	Disease Qualifier
C27993	General_Modifier	Qualifier	General Qualifier|General Modifier|General Qualifiers
C27994	Cardiotoxicity	Toxicity	Cardiotoxicity|Cardiac Toxicity|cardiotoxicity|toxicity, cardiac	Toxicity that affects the heart.
C27995	Urinary_Tract_Toxicity	Toxicity	Urinary Tract Toxicity|toxicity, urinary tract
C27996	Myocardial_Infarction	Myocardial_Disorder	Myocardial Infarction|Myocardial Infarct
C27997	New_York_Heart_Association_Classification_III_or_IV	Classification	NYHA III/IV
C27998	Hereditary	Patient_Characteristics_Modifier	Hereditary|hereditary	(ha-RED-ih-tair-ee) Transmitted from parent to child by information contained in the genes.
C27999	Hypervascular	General_Modifier	Hypervascular|hypervascular	Having a large number of blood vessels.
C28000	Autologous	General_Modifier	Autologous|autologous	(aw-TAHL-o-gus) Taken from an individual's own tissues, cells, or DNA.
C28002	Activate	General_Modifier	Activate|activate	In biology, to stimulate a cell in a resting state to become active. This causes biochemical and functional changes in the activated cell.
C28003	Ultrasound_Therapy	Hyperthermia_Treatment	Ultrasound Therapy|ultrasound energy	A form of therapy being studied as an anticancer treatment.  Intensified ultrasound energy can be directed at cancer cells to heat them and kill them.
C28004	Toxic	General_Modifier	Toxic|toxic	Having to do with poison or something harmful to the body. Toxic substances usually cause unwanted side effects.
C28005	Preventive	General_Modifier	Preventive|preventive	Used to prevent disease.
C28006	Postoperative	Temporal_Modifier	Postoperative|PO|Post-Operative|postoperative	After surgery.
C28007	Median	General_Modifier	Median|median	A statistics term. The middle value in a set of measurements.
C28008	Irreversible_Toxicity	Toxicity	Irreversible Toxicity|irreversible toxicity	Side effects that are caused by toxic substances or something harmful to the body and do not go away.
C28009	Hydration	Physical_Phenomena_or_Properties	Hydration|hydration	Combining with water.
C28010	Retrospective	General_Modifier	Retrospective|retrospective	Looking back at events that have already taken place.
C28011	Biliary	Anatomy_Modifier	Biliary|biliary	Having to do with the liver, bile ducts, and/or gallbladder.
C28012	unilateral	General_Modifier	unilateral	Having to do with one side of the body.
C28013	Karnofsky_Performance_Status	Performance_Status	Karnofsky Performance Status|K|KPS|Karnofsky|Karnofsky Scale	Karnofsky Performance Status. A standard way of measuring the ability of cancer patients to perform ordinary tasks.  The scores range from 0 to 100, with a higher score indicating a better ability to carry out daily activities.  KPS may be used to determine a patient's prognosis, to measure changes in functioning, or to decide if a patient could be included in a clinical trial.
C28014	Dose-Limiting	Properties_or_Attributes	Dose-Limiting|dose-limiting	Describes side effects of a drug or other treatment that are serious enough to prevent an increase in dose or level of that treatment.
C28015	Bioavailable	General_Modifier	Bioavailable|bioavailable	The ability of a drug or other substance to be absorbed and used by the body.  Orally bioavailable means that a drug or other substance that is taken by mouth can be absorbed and used by the body.
C28016	Gynecologic	Disease_Modifier	Gynecologic|GYN|gynecologic	Of or relating to or practicing gynecology; pertaining to the health issues of women.
C28017	Transdermal	General_Modifier	Transdermal|transdermal	Through the skin.
C28018	Inherited	Patient_Characteristics_Modifier	Inherited|Heritable|inherited	Transmitted through genes from parents to offspring. (genome.gov)
C28019	Contiguous	General_Modifier	Contiguous|contiguous	Touching or very close together.
C28020	Problem	Properties_or_Attributes	Problem|PROB	A difficulty, disorder, or condition needing resolution.
C28022	Internal_Radiation	Radiation_Therapy	Internal Radiation|internal radiation	(ray-dee-AY-shun) A procedure in which radioactive material sealed in needles, seeds, wires, or catheters is placed directly into or near a tumor. Also called brachytherapy, implant radiation, or interstitial radiation therapy.
C28023	Dilate	General_Modifier	Dilate|dilate	(DYE-late) To widen or enlarge an opening or hollow structure beyond its usual size, such as the pupil of the eye or a blood vessel.
C28024	Hormone_Responsive	Disease_Treatment_Modifier	Hormone Responsive|Hormone-sensitive|hormone responsive	In oncology, describes cancer that responds to hormone treatment.
C28025	Asymmetry	General_Modifier	Asymmetry|asymmetry	Lack or absence of balanced proportions between parts of a thing.
C28026	Epigastric	Anatomy_Modifier	Epigastric|epigastric	Having to do with the upper middle area of the abdomen.
C28027	Germ-Free	General_Modifier	Germ-Free|germ-free	Free of bacteria, disease-causing viruses, and other organisms that can cause infection.
C28028	Protozoal	General_Modifier	Protozoal|protozoal	Having to do with the simplest organisms in the animal kingdom. Protozoa are single-cell organisms, such as ameba, and are different from bacteria, which are not members of the animal kingdom. Some protozoa can be seen without a microscope.
C28029	Dose-dependent	General_Modifier	Dose-dependent|dose-dependent	Refers to the effects of treatment with a drug.  If the effects change when the dose of the drug is changed, the effects are said to be dose-dependent.
C28030	Biochemical_Reactions	Retired_Concepts	Biochemical Reactions|biochemical reactions
C28031	Mutate	General_Modifier	Mutate|mutate	To change the genetic material of a cell.  The changes (mutations) can be harmful, beneficial, or have no effect.
C28032	Nontoxic	General_Modifier	Nontoxic|nontoxic	Not harmful or destructive.
C28033	Pontine	Anatomy_Modifier	Pontine|pontine	Having to do with the pons (part of the central nervous system, located at the base of the brain, between the medulla oblongata and the midbrain).
C28034	Attenuated	General_Modifier	Attenuated|attenuated	Weakened or thinned.  Attenuated strains of disease-causing bacteria and viruses are often used as vaccines.  The weakened strains are used as vaccines because they stimulate a protective immune response while causing no disease or only mild disease in the person receiving the vaccine.
C28035	Intracolonic	Anatomy_Modifier	Intracolonic|intracolonic	Within the colon.
C28036	Intratumoral	General_Modifier	Intratumoral|intratumoral	Within a tumor.
C28037	Inviable	General_Modifier	Inviable|inviable	Not able to survive.
C28038	Replicate	General_Modifier	Replicate|replicate	To make a copy or duplicate of something.
C28039	Electron_Beam	Charged_Particles_Radiation	Electron Beam|electron beam	A stream of electrons (small negatively charged particles found in atoms) that can be used for radiation therapy.
C28040	Intralesional	General_Modifier	Intralesional|intralesional	Within a cancerous area, for example, within a tumor in the skin.
C28041	Investigational	General_Modifier	Investigational|investigational	Being studied; experimental.
C28042	Proliferative_Index	Properties_or_Attributes	Proliferative Index|proliferative index	A measure of the number of cells in a tumor that are dividing (proliferating). May be used with the S-phase fraction to give a more complete understanding of how fast a tumor is growing.
C28043	Metasynchronous	Disease_Clinical_Modifier	Metasynchronous|metasynchronous	Occurring at nearly the same time.
C28044	Isointense	General_Modifier	Isointense|isointense	Having the same intensity as another object.  Used to describe the results of imaging tests, such as x-rays, MRIs, or CT scans.
C28045	Nonlytic	Disease_Laboratory_Finding_Modifier	Nonlytic|nonlytic	In biology, refers to viruses that do not kill infected cells by disrupting their plasma membranes.
C28046	Nonseminomatous	Disease_Morphology_Modifier	Nonseminomatous|Nonseminoma|nonseminoma	(non-sem-ih-NO-ma) A group of testicular cancers that begin in the germ cells (cells that give rise to sperm). Nonseminomas are identified by the type of cell in which they begin and include embryonal carcinoma, teratoma, choriocarcinoma, and yolk sac carcinoma.
C28047	Ovarian	Anatomy_Modifier	Ovarian|ovarian	Having to do with the ovaries, the female reproductive glands in which the ova (eggs) are formed. The ovaries are located in the pelvis, one on each side of the uterus.
C28048	Anal	Anatomy_Modifier	Anal|anal	Having to do with the anus, which is the posterior opening of the large bowel.
C28049	Intracavitary_Radiation	Internal_Radiation	Intracavitary Radiation|intracavitary radiation	A radioactive source (implant) placed in a body cavity such as the chest cavity or the vagina.
C28050	Subependymal	Anatomy_Modifier	Subependymal|subependymal	(SUB-ep-EN-di-mal) Below the ependyma (the membrane that lines the ventricles of the brain and the central canal of the spinal cord).
C28051	Stage_0	Disease_Stage_Modifier	Stage 0
C28052	Stage_IB1	Stage_IB	Stage IB1
C28053	Stage_IB2	Stage_IB	Stage IB2
C28054	Stage_II	Disease_Stage_Modifier	Stage II|Stage 2
C28055	Stage_IVC	Stage_IV	Stage IVC
C28056	Stage_A	Disease_Stage_Modifier	Stage A
C28057	Stage_B	Disease_Stage_Modifier	Stage B
C28058	Stage_B1	Stage_B	Stage B1
C28059	Stage_B2	Stage_B	Stage B2
C28060	Stage_C	Disease_Stage_Modifier	Stage C
C28061	Stage_D	Disease_Stage_Modifier	Stage D
C28062	Stage_D1	Stage_D	Stage D1
C28063	Stage_D2	Stage_D	Stage D2
C28064	Extensive_Stage	Disease_Stage_Modifier	Extensive Stage
C28065	Limited_Stage	Disease_Stage_Modifier	Limited Stage
C28066	Stage_Unspecified	Disease_Stage_Modifier	Stage Unspecified
C28067	Hepatoblastoma_Stage	Disease_Stage_Modifier	Hepatoblastoma Stage
C28068	Postsurgical_Stage_I	Hepatoblastoma_Stage	Postsurgical Stage I
C28069	Postsurgical_Stage_II	Hepatoblastoma_Stage	Postsurgical Stage II
C28070	Postsurgical_Stage_III	Hepatoblastoma_Stage	Postsurgical Stage III
C28071	Postsurgical_Stage_IV	Hepatoblastoma_Stage	Postsurgical Stage IV
C28072	PRETEXT_Stage_1	Hepatoblastoma_Stage	PRETEXT Stage 1|PRETEXT Stage I|Pretreatment Extent of Disease Stage 1	Hepatoblastoma Pretreatment Extent of Disease System stage in which tumor involves only one quadrant, while the three adjoining liver quadrants are free of tumor. -- 2004
C28073	PRETEXT_Stage_2	Hepatoblastoma_Stage	PRETEXT Stage 2|PRETEXT Stage II|Pretreatment Extent of Disease Stage 2	Hepatoblastoma Pretreatment Extent of Disease System stage in which tumor involves two adjoining quadrants, while the other two adjoining liver quadrants are free of tumor. -- 2004
C28074	PRETEXT_Stage_3	Hepatoblastoma_Stage	PRETEXT Stage 3|PRETEXT Stage III|Pretreatment Extent of Disease Stage 3	Hepatoblastoma Pretreatment Extent of Disease System stage in which tumor involves three adjoining quadrants or two nonadjoining quadrants, while one quadrant or two nonadjoining liver quadrants are free of tumor. -- 2004
C28075	PRETEXT_Stage_4	Hepatoblastoma_Stage	PRETEXT Stage 4|PRETEXT Stage IV|Pretreatment Extent of Disease Stage 4	Hepatoblastoma Pretreatment Extent of Disease System stage in which tumor involves all four quadrants of the liver. -- 2004
C28076	Disease_Grade_Modifier	Disease_Modifier	Disease Grade Qualifier
C28077	Grade_1	Disease_Grade_Modifier	Grade 1|G1|Grade I
C28078	Grade_2	Disease_Grade_Modifier	Grade 2|G2|Grade II
C28079	Grade_3	Disease_Grade_Modifier	Grade 3|G3|Grade III
C28080	Grade_3a	Grade_3	Grade 3a
C28081	Grade_3b	Grade_3	Grade 3b
C28082	Grade_4	Disease_Grade_Modifier	Grade 4|G4|Grade IV
C28083	Intermediate_Grade	Disease_Grade_Modifier	Intermediate Grade
C28084	Gleason_Score_for_Prostate_Cancer	Disease_Grade_Modifier	Gleason Score for Prostate Cancer|GLEASON-SC|Gleason Score|Gleason Sum|Gleason score	The score derived from universally embraced prostate cancer grading system developed by Dr. Donald F. Gleason in 1977. The system provides a reproducible description of the glandular architecture of prostate tissue to which a pathologist assigns a score depending primarily on the microscopic patterns of cancerous glands and cell morphology. The system correlates well with behavior at the extremes: Gleason 1+1 tumors are the most well differentiated, slowly growing and rarely spread; Gleason 4+5 tumors are the most poorly differentiated, often widely metastatic at the time of diagnosis. In the commoner intermediate grade tumors, however, behavior is extremely variable.
C28085	Gleason_Grade_1	Gleason_Grade_for_Prostate_Cancer	Gleason Grade 1
C28086	Gleason_Grade_2	Gleason_Grade_for_Prostate_Cancer	Gleason Grade 2
C28087	Gleason_Grade_3	Gleason_Grade_for_Prostate_Cancer	Gleason Grade 3
C28088	Gleason_Grade_4	Gleason_Grade_for_Prostate_Cancer	Gleason Grade 4
C28089	Gleason_Grade_5	Gleason_Grade_for_Prostate_Cancer	Gleason Grade 5
C28090	Gleason_Score_6	Gleason_Score_for_Prostate_Cancer	Gleason Score 6
C28091	Gleason_Score_7	Gleason_Score_for_Prostate_Cancer	Gleason Score 7
C28092	Gleason_Score_8	Gleason_Score_for_Prostate_Cancer	Gleason Score 8
C28093	Gleason_Score_9	Gleason_Score_for_Prostate_Cancer	Gleason Score 9
C28094	Gleason_Score_10	Gleason_Score_for_Prostate_Cancer	Gleason Score 10
C28095	Gleason_Score_2	Gleason_Score_for_Prostate_Cancer	Gleason Score 2
C28096	Gleason_Score_3	Gleason_Score_for_Prostate_Cancer	Gleason Score 3
C28097	Gleason_Score_4	Gleason_Score_for_Prostate_Cancer	Gleason Score 4
C28098	Gleason_Score_5	Gleason_Score_for_Prostate_Cancer	Gleason Score 5
C28099	Disease_Morphology_Modifier	Disease_Modifier	Disease Morphology Qualifier
C28100	Disease_Gross_Finding_Modifier	Disease_Modifier	Disease Gross Finding Qualifier
C28101	Disease_Laboratory_Finding_Modifier	Disease_Modifier	Disease Laboratory Finding Qualifier
C28102	Disease_Clinical_Modifier	Disease_Modifier	Disease Clinical Qualifier
C28103	Disease_Treatment_Modifier	Disease_Modifier	Disease Treatment Qualifier
C28104	Patient_Characteristics_Modifier	Properties_or_Attributes	Patient Characteristics Qualifier
C28105	Distantly_Metastatic	Metastatic	Distantly Metastatic
C28106	Locally_Metastatic	Metastatic	Locally Metastatic
C28107	Gleason_Grade_for_Prostate_Cancer	Disease_Grade_Modifier	Gleason Grade for Prostate Cancer|Gleason Grade
C28108	Disease_Stage_Modifier	Disease_Modifier	Disease Stage Qualifier
C28109	Pleomorphic	General_Modifier	Pleomorphic|pleomorphic	Occurring in various distinct forms.  In terms of cells, having variation in the size and shape of cells or their nuclei.
C28110	Statistically_Significant	Properties_or_Attributes	Statistically Significant|statistically significant	Describes a mathematical measure of difference between groups. The difference is said to be statistically significant if it is greater than what might be expected to happen by chance alone.
C28121	Gene-Modified	Properties_or_Attributes	Gene-Modified|gene-modified	Cells that have been altered to contain different genetic material than they originally contained.
C28128	Cleaved_Cell	Other_Anatomic_Concept	Cleaved Cell|Cleaved|cleaved	Having to do with the appearance of cells when viewed under a microscope. The nucleus of cleaved cells appears divided or segmented.
C28129	Renal_Tubular_Acidosis	Fluid_and_Electrolyte_Manifestation	Renal Tubular Acidosis|renal tubular acidosis	(REE-nal TOO-bu-lar as-ih-DO-sis) A rare disorder in which structures in the kidney that filter the blood are impaired, producing urine that is more acid than normal.
C28130	Acrylonitrile	Organo-nitrogen_Carcinogen	Acrylonitrile|2-Propenenitrile|Cyanoethylene|Vinylcyanide|acrylonitrile	A colorless, volatile liquid with a pungent, onion-like odor. Acrylonitrile is widely used in industry to produce rubber, resins, plastics, elastomers and synthetic fibers and to manufacture carbon fibers used in aircraft, defense and aerospace industries. Exposure to acrylonitrile irritates the mucous membranes and causes a headache, nausea, dizziness, impaired judgment, difficulty breathing, limb weakness, cyanosis, convulsions and collapse. Acrylonitrile is reasonably anticipated to be a human carcinogen and may be associated with an increased risk of developing lung and prostate cancer. (NCI05)
C28131	Arsenic	Element_or_Isotope	Arsenic|arsenic	A poisonous chemical used to kill weeds and pests. Also used in cancer therapy.
C28132	Asthenia	Symptom	Asthenia|asthenia	Weakness; lack of energy and strength.
C28133	Blood_Cell_Count	Test|Test_Generic	Blood Cell Count|blood cell count	A test to check the number of red blood cells, white blood cells, and platelets in a sample of blood.  Also called complete blood count (CBC).
C28134	Bromelain	Protease	Bromelain|Bromelase|EC 3.4.22.33|Pineapple Enzyme|bromelain	A proteolytic enzyme obtained from the pineapple plant that cleaves sulhydryl groups. The enzyme is adsorbed intact through the gastrointestinal tract and has demonstrated therapeutic benefit. Bromelain has the ability to modulate cytokines, and has also demonstrated anti-inflammatory activity, immune response activity, and fibrinolytic activity.
C28135	Caloric_Intake	Properties_or_Attributes	Caloric Intake|caloric intake	Refers to the number of calories (energy content) consumed.
C28136	Camphor	Topical_Anti-Infective_Agent	Camphor|camphor	A substance that comes from the wood and bark of the camphor tree or is made in the laboratory. It has a very unique smell and taste and is used in commercial products (for example, mothballs). Camphor is used in topical anti-infective and anti-pruritic (anti-itching) agents.
C28137	Oral_Candidiasis	Candidiasis	Oral Candidiasis|Thrush|thrush	A condition in which Candida albicans, a type of yeast, grows out of control in moist skin areas of the body. It is usually a result of a weakened immune system, but can be a side effect of chemotherapy or treatment with antibiotics. Thrush usually affects the mouth (oral thrush); however, rarely, it spreads throughout the entire body. Also called Candidiasis or Candidosis.
C28138	Catechol	Phenol_Compound	Catechol|1,2 dihydroxybenzene|1,2-Benzenediol|2-Hydroxyphenol|Pyrocatechin|Pyrocatechol|catechol	A chemical originally isolated from a type of mimosa tree. Catechol is used as an astringent, an antiseptic, and in photography, electroplating, and making other chemicals. It can also be man-made.
C28139	Decortication	Surgical_Procedure	Decortication|decortication	(de-KOR-tih-KAY-shun) Removal of part or all of the external surface of an organ.
C28140	Chlorine	Element_or_Isotope	Chlorine|chlorine	A chemical used to disinfect water and as a bleach.
C28141	Chondroitin_Sulfate	Glycosaminoglycan	Chondroitin Sulfate|Chondroitin|chondroitin sulfate	The major glycosaminoglycan (a type of sugar molecule) in cartilage.
C28142	Collagen_Disease	Retired_Concepts	Collagen Disease|collagen disease	A term previously used to describe chronic diseases of the connective tissue (e.g., rheumatoid arthritis, systemic lupus erythematosus, and systemic sclerosis), but now is thought to be more appropriate for diseases associated with defects in collagen, which is a component of the connective tissue.
C28143	Control_Group	Population_Group	Control Group|control group	A group used as a standard of comparison in a control experiment.
C28144	Drug_Tolerance	Retired_Concepts	Drug Tolerance|drug tolerance	A condition that occurs when the body gets used to a medicine so that either more medicine is needed or different medicine is needed.
C28145	Dysgeusia	Alterations_in_Smell_or_Taste	Dysgeusia|dysgeusia|parageusia	A bad taste in the mouth.
C28146	Electroacupuncture	Palliative_Care	Electroacupuncture|electroacupuncture	A procedure in which pulses of weak electrical current are sent through acupuncture needles into acupuncture points in the skin.  This procedure is being studied in the prevention of nausea and vomiting in patients undergoing chemotherapy.
C28147	Embryo	Embryonic_Structure	Embryo|embryo	Early stage in the development of a plant or an animal.  In vertebrate animals (have a backbone or spinal column), this stage lasts from shortly after fertilization until all major body parts appear.  In particular, in humans, this stage lasts from about 2 weeks after fertilization until the end of the seventh or eighth week of pregnancy.
C28148	Enema_Administration	Procedure	Enema Administration
C28149	Fluoride	Inorganic_Chemical	Fluoride|fluoride	A chemical that helps prevent tooth decay.  Fluoride may be present in drinking water or applied to the teeth.
C28150	Freeze-Drying	Preservation_Technique	Freeze-Drying|freeze-dried	A method used to dry substances, such as food, to make them last longer. The substance is frozen and then dried in a vacuum.
C28151	Gluconeogenesis	Carbohydrate_Metabolism	Gluconeogenesis|gluconeogenesis	The biosynthesis of new glucose as opposed to that generated by the metabolism of glycogen. Gluconeogenesis occurs mainly in the liver or kidneys, and involves the biosynthesis of glucose from 3-carbon or 4-carbon non-carbohydrate precursors such as amino acids or fats.
C28152	Glycolysis	Carbohydrate_Metabolism	Glycolysis|glycolysis	A process in which glucose (sugar) is partially broken down by cells in enzyme reactions that do not need oxygen. Glycolysis is one method that cells use to produce energy. When glycolysis is linked with other enzyme reactions that use oxygen, more complete breakdown of glucose is possible and more energy is produced.
C28153	Glycosaminoglycan	Polysaccharide	Glycosaminoglycan|glycosaminoglycan	A type of long, unbranched polysaccharide molecule.  Glycosaminoglycans are major structural components of cartilage and are also found in the cornea of the eye.
C28154	Hormone_Receptor	Cell_Surface_Receptor	Hormone Receptor|hormone receptor	A protein on the surface of a cell that binds to a specific hormone.  The hormone causes many changes to take place in the cell.
C28155	Horner_s_Syndrome	Neuropathy	Horner's Syndrome|Horner's syndrome	A condition in which one side of the face is flushed, does not produce sweat, and has a constricted pupil and drooping eyelid.  It can be caused by an injury to, or paralysis of, nerves in the neck, or by a tumor.
C28156	Hydrogen_Peroxide	Topical_Anti-Infective_Agent	Hydrogen Peroxide|H2O2|hydrogen peroxide	A chemical used in bleaches, dyes, cleansers, antiseptics, and disinfectants. In a concentrated form, it is toxic and irritating to tissues.
C28157	_5-Hydroxyindoleacetic_Acid	Diagnostic_Reagent	5-Hydroxyindoleacetic Acid|5-hydroxyindoleacetic acid	5HIAA. A breakdown product of serotonin that is excreted in the urine.  Serotonin is a hormone found at high levels in many body tissues.  Serotonin and 5HIAA are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors.
C28158	Hypnosis	Hypnotherapy	Hypnosis|hypnosis	A trance-like state in which a person becomes more aware and focused and is more open to suggestion.
C28159	Immunocompetence	General_Modifier	Immunocompetence|immunocompetence	The ability to produce a normal immune response.
C28160	Injection	Procedure	Injection|injection	Use of a syringe and needle to push fluids or drugs into the body; often called a "shot."
C28161	Intramuscular_Injection	Parenteral_Route_of_Drug_Administration	Intramuscular Route of Administration|IM|INTRAMUSCULAR|Intramuscular Administration of Drug|Intramuscular Injection|intramuscular injection	Administration within a muscle.
C28162	Intravenous_Injection	Retired_Concepts	Intravenous Injection|intravenous injection	IV.  Injection into a vein.
C28163	Inositol	Intracellular_Second_Messenger	Inositol|Cyclohexanehexol|cis-1,2,3,5-trans-4,6-Cyclohexanehexol|inositol|myo-Inositol	A natural sugar found in cell membrane phospholipids, plasma lipoproteins, and (as the phosphate form) in the nucleus with potential chemopreventive properties. As one of a number of intracellular phosphate compounds, inositol is involved in cell signaling and may stimulate tumor cell differentiation. (NCI04)
C28164	Keratan_Sulfate	Glycosaminoglycan	Keratan Sulfate|keratan sulfate	A glycosaminoglycan (a type of polysaccharide) found in cartilage and in the cornea of the eye.
C28165	Klebsiella	Bacteria	Klebsiella	A bacteria that frequently causes lung, urinary tract, intestinal, and wound infections.
C28166	Lactose	Oligosaccharide	Lactose|lactose	A type of sugar found in milk and milk products.
C28167	Laparoscope	Endoscope	Laparoscope|laparoscope	A long, thin tube with a camera lens attached that allows the physician to examine the organs inside the abdominal cavity.
C28168	Lentinan	Nutritional_Supplement	Lentinan|lentinan	A beta-glucan (a type of polysaccharide) from the mushroom Lentinus edodes (shiitake mushroom).  It has been studied in Japan as a treatment for cancer.
C28169	Linear_Accelerator	Medical_Device	Linear Accelerator|linear accelerator	A machine that creates high-energy radiation to treat cancer, using electricity to form a stream of fast-moving subatomic particles.  Also called mega-voltage (MeV) linear accelerator or a linac.
C28170	Myelin	Other_Anatomic_Concept	Myelin|myelin	(MYE-eh-lin) The fatty substance that covers and protects nerves.
C28171	narcotic	Retired_Concepts	narcotic
C28172	Nebulizer	Drug_Delivery_System	Nebulizer|nebulizer	A device used to turn liquid into a fine spray.
C28173	Nerve_Block	Retired_Concepts	Nerve Block|nerve block
C28174	Occupational_Therapist	Allied_Health_Profession	Occupational Therapist|occupational therapist	A health professional trained to help people who are ill or disabled learn to manage their daily activities.
C28175	Parachloroamphetamine	Neurotoxin	Parachloroamphetamine|PCA
C28176	Parasite	Other_Organism_Groupings	Parasite|parasite	An animal or a plant that lives on or in an organism of another species and gets some or all of its nutrients from it.
C28177	Paresthesia	Sensory_Manifestations	Paresthesia|paresthesias	Abnormal touch sensations, such as burning or prickling, that occur without an outside stimulus.
C28178	Plant_Sterol	Drug_Natural_Product	Plant Sterol|phytosterols|plant sterols	Plant-based compounds that can compete with dietary cholesterol to be absorbed by the intestines, resulting in lower blood cholesterol levels.  Phytosterols may have some effect in cancer prevention.
C28179	Polysaccharide	Carbohydrate	Polysaccharide|polysaccharide	A type of carbohydrate. It contains sugar molecules that are linked together chemically.
C28180	Prescription	Document_Type	Prescription|prescription	A doctor's order for medicine or another intervention.
C28181	Psychologist	Miscellaneous_Occupations	Psychologist|psychologist	A specialist who can talk with patients and their families about emotional and personal matters, and can help them make decisions.
C28182	Rabies	Viral_Infection	Rabies|rabies	A disease of the nervous system caused by the rabies virus.  Rabies is marked by an increase in saliva production, abnormal behavior, and eventual paralysis and death.
C28183	Radioactive_Fallout	Industrial_Product	Radioactive Fallout|radioactive fallout	(RAY-dee-o-AK-tiv) Airborne radioactive particles that fall to the ground during and after an atomic bombing, nuclear weapons test, or nuclear plant accident.
C28184	Relaxation_Technique	Palliative_Care	Relaxation Technique|relaxation techniques	Methods used to reduce tension and anxiety, and control pain.
C28185	Resting	Conceptual_Entities	Resting|resting	In biology, refers to a cell that is not dividing.
C28186	Selection_Bias	Conceptual_Entities	Selection Bias|selection bias	An error in choosing the individuals or groups to take part in a study.  Ideally, the subjects in a study should be very similar to one another and to the larger population from which they are drawn (for example, all individuals with the same disease or condition).  If there are important differences, the results of the study may not be valid.
C28187	Serum_Albumin	Other_Anatomic_Concept	Serum Albumin|serum albumin	The main protein in blood plasma. Low levels of serum albumin occur in people with malnutrition, inflammation, and serious liver and kidney disease.
C28188	Sialic_Acid	Carbohydrate	Sialic Acid|sialic acid	A type of sugar molecule.
C28189	Silicone	Biomaterials	Silicone|silicone	A synthetic gel that is used as an outer coating on breast implants and as the inside filling of some implants.
C28190	Social_Worker	Allied_Health_Profession	Social Worker|social worker	A professional trained to talk with people and their families about emotional or physical needs, and to find them support services.
C28191	Sulfuric_Acid	Reagent	Sulfuric Acid|sulfuric acid	A strong acid that, when concentrated is extremely corrosive to the skin and mucous membranes.  It is used in making fertilizers, dyes, electroplating, and industrial explosives.
C28192	Survival_Rate	Conceptual_Entities	Survival Rate|survival rate	The percentage of people in a study or treatment group who are alive for a given period of time after diagnosis.  This is commonly expressed as 5-year survival.
C28193	Syndrome	Diseases_and_Disorders	Syndrome|syndrome	(SIN-drome) A set of symptoms or conditions that occur together and suggest the presence of a certain disease or an increased chance of developing the disease.
C28194	Telangiectasia	Vascular_Ectasia	Telangiectasia|telangiectasia	(tel-AN-gee-ek-TAY-zha) The permanent enlargement of blood vessels, causing redness in the skin or mucous membranes.
C28195	Thromboembolism	Embolism	Thromboembolism
C28197	Anxiolytic	Adjuvant_Analgesic	Anxiolytic|anxiolytic	A medicine used to treat anxiety or muscle spasms.
C28198	Virulence	General_Modifier	Virulence|virulence	The ability of a microorganism to cause damage to its host.
C28199	Yttrium	Element_or_Isotope	Yttrium|yttrium	(IH-tree-um) A rare elemental metal.  A radioactive form of yttrium is used in radiation therapy and some types of immunotherapy.
C28200	Aluminum_Sulfate	Retired_Concepts	Aluminum Sulfate|aluminum sulfate	A type of immune adjuvant (a substance used to help boost the immune response to a vaccine).
C28201	Biochanin_A	Isoflavone	Biochanin A|5,7-Dihydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one|5,7-Dihydroxy-4'-methoxyisoflavone|Genistein 4-Methylether|biochanin A	An isoflavone found in soy products. Soy isoflavones are being studied to see if they help prevent cancer.
C28202	Nitric_Acid	Reagent	Nitric Acid|nitric acid	A toxic, corrosive, colorless liquid used to make fertilizers, dyes, explosives, and other chemicals.
C28203	Polyphenol	Antioxidant	Polyphenol|polyphenol	A substance that is found in many plants and gives some flowers, fruits, and vegetables their color. Polyphenols have antioxidant activity.
C28204	Potassium_Hydroxide	Reagent	Potassium Hydroxide|potassium hydroxide	A toxic and highly corrosive chemical used to make soap, in bleaching, and as a paint remover.  It is used in small amounts as a food additive and in the preparation of some drugs.
C28205	Sodium_Sulfite	Reagent	Sodium Sulfite|SODIUM SULFITE|sodium sulfite	A chemical used in photography, paper making, water treatment, and for other purposes.
C28206	Viscotoxin	Toxin	Viscotoxin|viscotoxin	A member of a group of small proteins produced by mistletoe plants that are able to kill cells and may stimulate the immune system.
C28207	Patient-Controlled_Analgesia	Retired_Concepts	Patient-Controlled Analgesia|patient-controlled analgesia
C28208	Mohs_Surgery	Surgical_Procedure	Mohs Surgery|Mohs surgery	A surgical technique used to treat skin cancer. Individual layers of cancerous tissue are removed and examined under a microscope one at a time until all cancerous tissue has been removed.
C28209	Obtundation	Nervous_System_Finding	Obtundation|obtundation	(ob-tun-DAY-shun) A dulled or reduced level of alertness or consciousness.
C28210	Photophobia	Visual_Manifestations	Photophobia|photophobia	A condition in which the eyes are more sensitive to light than normal.
C28211	Enclomiphene	Clomiphene	Enclomiphene|Enclomifene|ICI 46476|RMI 16,289|trans Clomiphene|trans-2-(4-(2-Chloro-1,2-diphenylethenyl)phenoxy)-N,N-diethylethanamine	The trans-isomer of clomiphene citrate (CC).  Enclomiphene has a higher rate of clearance and is less active than the cis-isomer, cis-clomiphene.  Clomiphene citrate has been evaluated for antineoplastic activity against breast cancer. (NCI04)
C28213	Intradermal	General_Modifier	Intradermal|intradermal	Within the dermis, which is the layer of skin below the epidermis (outermost layer).
C28214	Barbiturate_Intoxication	Intoxication	Barbiturate Intoxication
C28215	Transplanted_Pancreas_Complication	Transplanted_Organ_Complication	Transplanted Pancreas Complication
C28216	Chorioallantoic_Membrane	Experimental_Organism_Anatomical_Concepts	Chorioallantoic Membrane|chorioallantoic membrane	The membrane in hen's eggs that helps chicken embryos get enough oxygen and calcium for development.  The calcium comes from the egg shell.
C28217	Intracellular	General_Modifier	Intracellular|intracellular	Inside a cell.
C28218	Scalpel	Medical_Device	Scalpel|scalpel	(SKAL-pul) A small, thin knife used for surgery.
C28219	Electron_Microscope	Microscope	Electron Microscope|electron microscope	A microscope (device used to magnify small objects) that uses electrons (instead of light) to produce an enlarged image.  An electron microscope shows tiny details better than any other type of microscope.
C28220	Sensor	Medical_Device	Sensor|sensor	A device that responds to a stimulus, such as heat, light, or pressure, and generates a signal that can be measured or interpreted.
C28221	Phlebotomy	Diagnostic_Procedure	Phlebotomy|Venipuncture|phlebotomy|venipuncture	Technique used to draw blood from a vein for diagnostic purposes or for treatment of certain blood disorders. (From MSH 2002)
C28222	Disseminate	General_Modifier	Disseminate|disseminate	(dih-SEM-ih-NATE) Scatter or distribute over a large area or range.
C28223	Endogenous	General_Modifier	Endogenous|endogenous	Produced inside an organism or cell. The opposite is external (exogenous) production.
C28224	Focal	Disease_Modifier	Focal|focal	In terms of cancer, limited to a specific area.
C28225	Latent	General_Modifier	Latent|latent	Describes a condition that is present but not active or causing symptoms.
C28226	Biological	General_Modifier	Biological|BIO|biological	In medicine, a substance made from living organisms or things they produce, such as a vaccine. Some biologicals stimulate or restore the ability of the immune system to fight infection and disease.
C28227	Bispecific_Monoclonal_Antibody	Bispecific_Antibody	Bispecific Monoclonal Antibody|bispecific monoclonal antibody	A monoclonal antibody that binds two different types of antigen.  Bispecific monoclonal antibodies do not occur naturally; they must be made in the laboratory.
C28228	Metabolic_Acidosis	Electrolyte_Disorder	Acidosis|Metabolic Acidosis|metabolic acidosis	(met-ah-BOL-ik as-id-O-sis) A condition in which the blood is too acidic.  It may be caused by severe illness or sepsis (bacteria in the bloodstream).
C28229	Ingestion	Swallowing	Ingestion|ingestion	Taking into the body by mouth.
C28230	Conditioned_Stimulus	Stimulus	Conditioned Stimulus|conditioned stimulus	A situation in which one signal, or stimulus, is given just before another signal. After this happens several times, the first signal alone can cause the response that would usually need the second signal.
C28231	Nutritionist	Allied_Health_Profession	Nutritionist|nutritionist	A health professional with special training in nutrition who can offer help with the choice of foods a person eats and drinks.  Also called a dietitian.
C28232	Bias	Conceptual_Entities	Bias|bias	Any deviation of results or inferences from the truth, or processes leading to such deviation.
C28233	Single_Blind_Study	Study_Design	Single Blind Study|single blind study	A type of clinical trial in which only the doctor knows whether a patient is taking the standard treatment or the new treatment being tested.  This helps prevent bias in treatment studies.
C28234	Progression-free_Survival	Clinical_Trial_Design	Progression-free Survival|progression-free survival	One type of measurement that can be used in a clinical study or trial to help determine whether a new treatment is effective.  It refers to the probability that a patient will remain alive, without the disease getting worse.
C28235	Valacyclovir	Nucleic_Acid_Synthesis_Inhibitor	Valacyclovir|valacyclovir	A substance that is being studied in the prevention of fungal, bacterial, and viral infections in patients undergoing donor stem cell transplantation with cells that are infected with cytomegalovirus. It belongs to the family of drugs called antivirals.
C28236	Foot_Fracture	Lower_Extremity_Fracture	Foot Fracture
C28237	Clinical_Practice_Guidelines	Guidelines	Clinical Practice Guidelines|clinical practice guidelines	Guidelines developed to help health care professionals and patients make decisions about screening, prevention, or treatment of a specific health condition.
C28238	Soft_Diet	Diet	Soft Diet|soft diet	A diet consisting of bland foods that are softened by cooking, mashing, pureeing, or blending.
C28239	Cobalt_60	Radioisotope	Cobalt 60|cobalt 60	A radioactive form of the metal cobalt, which is used as a source of radiation to treat cancer.
C28240	Metabolic	General_Modifier	Metabolic|metabolic	Having to do with metabolism.
C28241	Effector_Cell	Cell	Effector Cell|effector cell	A cell that performs a specific function in response to a stimulus; usually used to describe cells in the immune system.
C28242	Idiopathic	General_Modifier	Idiopathic|idiopathic	Describes a disease of unknown cause.
C28243	Oncolysis	General_Modifier	Oncolysis|oncolysis	The breakdown, or lysis, of a tumor. This can occur by mechanical means, chemicals, or infectious agents such as viruses. Oncolytic viruses do not lyse most normal cells.
C28244	Birt-Hogg-Dube_Syndrome	Hereditary_Neoplastic_Syndrome	Birt-Hogg-Dube Syndrome|Birt-Hogg-Dube syndrome	An inherited condition in which benign tumors develop in hair follicles on the head, chest, back, and arms.  People who have this disorder may be at increased risk of developing colon or kidney cancer.
C28245	Inhalation	Conceptual_Entities	Inhalation|inhalation	In medicine, refers to the act of taking a substance into the body by breathing.
C28246	Dysesthesia	Sensory_Manifestations	Dysesthesia|dysesthesia	A condition in which a sense, especially touch, is distorted. Dysesthesia can cause an ordinary stimulus to be unpleasant or painful. It can also cause insensitivity to a stimulus.
C28247	Speech_Therapist	Allied_Health_Profession	Speech Therapist|speech therapist	A specialist who evaluates and treats people with communication and swallowing problems. Also called a speech pathologist.
C28248	Dietitian	Allied_Health_Profession	Dietitian|dietitian	A health professional with special training in nutrition who can offer help with the choice of foods a person eats and drinks.  Also called a nutritionist.
C28249	Scientist	Miscellaneous_Occupations	Scientist|scientist	A person who has studied science, especially one who is active in a particular field of investigation.
C28250	Nothing_by_Mouth	Treatment	Nothing by Mouth|NPO	A Latin abbreviation for "nothing by mouth".
C28251	Millimeter	Unit_of_Length|Unit_of_Potency	Millimeter|MILLIMETER|MM|mm	A measure of length.  A millimeter is approximately 26 times smaller than an inch.
C28252	Kilogram	Base_Unit_of_International_System_of_Units|Unit_of_Mass|Unit_of_Potency	Kilogram|KG|KILOGRAM|Kg	A unit of mass equal to 1,000 grams and 2.2 pounds.
C28253	Milligram	Unit_of_Mass|Unit_of_Potency	Milligram|MG|MILLIGRAM|mg	A measure of weight.  A milligram is approximately 450,000 times smaller than a pound and 28,000 times smaller than an ounce.
C28254	Milliliter	Unit_of_Potency|Unit_of_Volume	Milliliter|CU CM|CUBIC CENTIMETER|Cubic Centimeter|MILLILITER|ML|cc|cm3|milliliter|ml	A measure of volume for a liquid.  A milliliter is approximately 950 times smaller than a quart and 30 times smaller than a fluid ounce.  A milliliter of liquid and a cubic centimeter (cc) of liquid are the same.
C28255	International_Unit	Retired_Concepts	International Unit|IU	International unit. A unit of measurement based on the International System of Units. This system defines units to measure length, time, mass, electric current, temperature, light intensity, and the amount of a substance. It can be used to express measurements of fat-soluble vitamins and some hormones, enzymes, and drugs.
C28256	Retroperitoneal	General_Modifier	Retroperitoneal|retroperitoneal	(RET-row-PAIR-ih-toe-NEE-ul) Having to do with the area outside or behind the peritoneum (the tissue that lines the abdominal wall and covers most of the organs in the abdomen).
C28257	Pathological_Staging	Staging	Pathological Staging|pathological staging	A method used to determine the stage of cancer. Tissue samples are removed during surgery or a biopsy. The stage is determined based on how the cells in the samples look under a microscope.
C28258	Condom	Contraceptive_Device	Condom|Prophylactic|prophylactic	In medicine, something that prevents or protects.
C28259	Sensory	General_Modifier	Sensory|sensory	Having to do with the senses.
C28260	Phantom_Limb_Pain	Pain	Phantom Limb Pain|phantom limb pain	The sensation of pain or other unpleasant feelings in the place of a missing (phantom) limb.
C28261	Mung_Bean	Nutritional_Supplement	Mung Bean|mung bean	A type of bean grown in warm climates, usually for its seed and for bean sprouts. Mung bean may have anticancer effects.
C28262	Chronic_Phase	Disease_Modifier	Chronic Phase|chronic phase	(KRAHN-ik) Refers to the early stages of chronic myelogenous leukemia or chronic lymphocytic leukemia. The number of mature and immature abnormal white blood cells in the bone marrow and blood is higher than normal, but lower than in the accelerated or blast phase.
C28263	Accelerated_Phase	Disease_Modifier	Accelerated Phase|accelerated phase	(ak-SEL-er-ay-ted) Refers to chronic myelogenous leukemia that is progressing. The number of immature, abnormal white blood cells in the bone marrow and blood is higher than in the chronic phase but not as high as in the blast phase.
C28264	Localization	Disease_Modifier	Localization|localization	(LO-kal-ih-ZAY-shun) The process of determining or marking the location or site of a lesion or disease. May also refer to the process of keeping a lesion or disease in a specific location or site.
C28265	Light_Microscope	Microscope	Light Microscope|light microscope	A microscope (device to magnify small objects) in which objects are lit directly by white light.
C28266	Mold	Fungi	Mold|mold	A form of fungus. Some molds can cause disease in humans.
C28267	Urea_Nitrogen_Retired	Retired_Concepts	Urea Nitrogen|urea nitrogen	A chemical in the blood produced by the breakdown of protein.  Urea nitrogen is removed from the blood by the kidneys.  Blood urea nitrogen (BUN) tests are sometimes done to see how well the kidneys are working.
C28268	Burr_Hole	Surgically_Created_Structure	Burr Hole|burr hole	A small opening in the skull made with a surgical drill.
C28269	Phytochemical	Drug_Natural_Product	Phytochemical|phytochemicals	Any chemical compound derived from, or present in, plants.
C28270	Transplant_Surgeon	Surgeon	Transplant Surgeon|transplant surgeon	A doctor who specializes in transplantation surgery.  The surgeon replaces a patient's organ with an organ from another person.
C28272	Molecular_Mass	Physical_Phenomena_or_Properties	Molecular Mass|molecular mass	The sum of the atomic masses of all atoms in a molecule, based on a scale in which the atomic masses of hydrogen, carbon, nitrogen, and oxygen are 1, 12, 14, and 16, respectively.  For example, the molecular mass of water, which has two atoms of hydrogen and one atom of oxygen, is 18 (i.e., 2 + 16).
C28273	Aqueous	General_Modifier	Aqueous|aqueous	Having to do with water.
C28276	Skin_Patch	Patch	Skin Patch|skin patch	A bandage-like patch that releases medicine into the body through the skin.  The medicine enters the blood slowly and steadily.
C28277	Pathology_Report	Report	Pathology Report|pathology report	A report that provides a description of the gross and microscopic examination of the specimen and is used to make a diagnosis and to determine treatment. It defines which structures and organs of the body are involved by the tumor, verifies the primary site of the cancer and describes the extent to which it has spread.
C28278	Laboratory_Study	Research_Activity	Laboratory Study|laboratory study	Research done in a laboratory. These studies may use test tubes or animals to  find out if a drug, procedure, or treatment is likely to be useful.  Laboratory studies take place before any testing is done in humans.
C28279	Controlled_Study	Study_Design	Controlled Study|controlled study	An experiment or clinical trial that includes a comparison (control) group.
C28280	Uncontrolled_Study	Study_Design	Uncontrolled Study|uncontrolled study	A clinical study that lacks a comparison (i.e., a control) group.
C28282	Predictive_Factor	Diagnostic_or_Prognostic_Factor	Predictive Factor|predictive factor	(pre-DIK-tiv) A situation or condition that may increase a person's risk of developing a certain disease or disorder.
C28283	Intoxication	Finding_by_Cause	Intoxication
C28284	Filler	Drug_Vehicle	Filler|filler	An inactive substance used to make a product bigger or easier to handle.  For example, fillers are often used to make pills or capsules because the amount of active drug is too small to be handled conveniently.
C28285	Stage_Is	Disease_Stage_Modifier	Stage Is|Stage 1S
C28286	Insomnia	Sleep_Disorder	Insomnia|insomnia	Difficulty in going to sleep or getting enough sleep.
C28287	Viscera	Other_Anatomic_Concept	Viscera|viscera	The soft internal organs of the body, including the lungs, the heart, and the organs of the digestive, excretory, and reproductive systems.
C28288	UGT1A1_Protein	Glycosyltransferase	UDP-Glucuronosyltransferase 1A1|Bilirubin Specific UDPGT Isozyme 1|HUG-BR1|UDP-Glucuronosyltransferase 1-1|UDPGT|UGT1A|UGT1A1	A substance that is being studied as a treatment for cancer. It is an enzyme produced by the liver and intestine.
C28289	Enema	Procedure	Enema|enema	The injection of a liquid through the anus into the large bowel.
C28290	Panacea	Conceptual_Entities	Panacea|panacea	A cure-all.
C28292	Squamous_Cell_Carcinoma_In_Situ_of_the_Nipple	Nipple_Carcinoma|Stage_0_Squamous_Cell_Carcinoma	Squamous Cell Carcinoma In Situ of the Nipple|Intraepidermal Squamous Carcinoma of Nipple|Intraepidermal Squamous Carcinoma of the Nipple|Nipple Intraepidermal Squamous Carcinoma|Squamous Cell Carcinoma In Situ of Nipple	An intraepidermal squamous cell carcinoma involving the area of the nipple. -- 2003
C28293	Outpatient	Patient	Outpatient|outpatient	A patient who comes to the hospital, clinic, or another medical facility for diagnosis and/or treatment but is not hospitalised (does not occupy a bed or ward). Outpatient care is called ambulatory care.
C28294	Nutrition	Conceptual_Entities	Nutrition|nutrition	The taking in and use of food and other nourishing material by the body.  Nutrition is a 3-part process.  First, food or drink is consumed.  Second, the body breaks down the food or drink into nutrients.  Third, the nutrients travel through the bloodstream to different parts of the body where they are used as "fuel" and for many other purposes.  To give the body proper nutrition, a person has to eat and drink enough of the foods that contain key nutrients.
C28295	Randomized	General_Modifier	Randomized|randomized	 To make random in arrangement, especially in order to control the variables in an experiment. (dictionary.com)
C28296	Experimental	General_Modifier	Experimental|experimental	Being studied; investigational.
C28297	Pilocytic	Properties_or_Attributes	Pilocytic|pilocytic	(PI-lo-SIT-ik) Made up of cells that look like fibers when viewed under a microscope.
C28301	Physician_Data_Query	Database	Physician Data Query	PDQ.  The Physician Data Query is an online database developed and maintained by the National Cancer Institute.  Designed to make the most current, credible, and accurate cancer information available to health professionals and the public, PDQ contains peer-reviewed summaries on cancer treatment, screening, prevention, genetics, and supportive care; a registry of cancer clinical trials from around the world; and directories of physicians, professionals who provide genetics services, and organizations that provide cancer care. Most of this information is available on the Cancer.gov Web site.  More specific information about PDQ can be found at http://cancer.gov/cancer_information/pdq/.
C28302	Advanced_Adult_Primary_Hepatocellular_Carcinoma	Adult_Hepatocellular_Carcinoma	Advanced Adult Hepatocellular Carcinoma|Advanced Adult Hepatoma
C28303	Aggressive_Lymphoma	Retired_Concepts	Aggressive Lymphoma|aggressive lymphoma	A quickly growing cancer that arises in the cells of the lymphatic system.
C28304	Stage_I_Mesothelioma	Malignant_Mesothelioma	Stage I Mesothelioma|stage I mesothelioma	Cancer found in the lining of the chest cavity near the lung and heart, in the diaphragm (the thin muscle below the lungs and heart that separates the chest from the abdomen), or in the lung.
C28305	Stage_II_Mesothelioma	Malignant_Mesothelioma	Stage II Mesothelioma|stage II mesothelioma	Cancer that has spread beyond the lining of the chest to lymph nodes in the chest.
C28306	Stage_III_Mesothelioma	Malignant_Mesothelioma	Stage III Mesothelioma|stage III mesothelioma	Cancer has spread into the lung, chest wall, diaphragm (the muscle between the chest and the abdomen), the sac surrounding the heart, or the ribs.  It may also have spread to other organs or tissues in the chest.
C28307	Stage_IV_Mesothelioma	Malignant_Mesothelioma	Stage IV Mesothelioma|stage IV mesothelioma	Cancer has spread to distant organs or tissues.
C28308	APC_Vaccine	Antineoplastic_Vaccine	APC Vaccine|APC vaccine|antigen-presenting cell vaccine	A vaccine made of antigens and antigen-presenting cells (APCs).  Also called APC vaccine.
C28309	Whole_Cell_Vaccine	Vaccine	Whole Cell Vaccine|whole cell vaccine	Vaccine made from whole tumor cells that have been changed in the laboratory.
C28310	Dendritic_Cell_Vaccine	APC_Vaccine	Dendritic Cell Vaccine|dendritic cell vaccine	A vaccine made of antigens and dendritic antigen-presenting cells (APCs).
C28311	Breast_Carcinoma_Metastatic_to_the_Skin	Metastasis_to_Skin|Metastatic_Carcinoma|Stage_IV_Breast_Cancer	Breast Carcinoma Metastatic to the Skin|Cutaneous Breast Cancer|cutaneous breast cancer	Cancer that has spread from the breast to the skin.
C28312	High-Risk_Cancer	Properties_or_Attributes	High-Risk Cancer|high-risk cancer	Cancer that is likely to recur (come back), or spread.
C28313	Endothelin_Receptor_Antagonist	Miscellaneous_Angiogenesis_Inhibitor	Endothelin Receptor Antagonist|endothelin receptor antagonists	A family of drugs that block the hormone endothelin and may prevent prostate cancer from spreading to the bones. They may also prevent the growth and spread of other types of cancer, including colorectal cancer.
C28314	Lhermitte_s_Sign	Neurological_Signs_and_Symptoms	Lhermitte's Sign|Lhermitte's sign	(lair-MEETS) A sensation similar to an electrical shock radiating from the back of the head down the spine as the neck is bent forward.
C28315	Normal_Renal_Arteriogram	Radiologic_Finding	Normal Renal Arteriogram
C28316	Aggravated_Acne	Acne	Aggravated Acne
C28317	Normal_Carotid_Arteriogram	Radiologic_Finding	Normal Carotid Arteriogram
C28318	Normal_Cerebral_Arteriogram	Radiologic_Finding	Normal Cerebral Arteriogram
C28319	Normal_Coronary_Arteriogram	Radiologic_Finding	Normal Coronary Arteriogram
C28320	Booster	Vaccine_Therapy	Booster|booster	In medicine, refers to a vaccination given after a previous vaccination.  A booster helps maintain or increase a protective immune response.
C28322	Cisclomiphene	Clomiphene	Cisclomiphene|Cis Clomiphene|Cis-Clomiphene Citrate|Cisclomiphene Citrate|Clomiphene citrate, cis-|Zuclomiphene|cis-Clomiphene citrate	The cis isomer of clomiphene which exhibits weak estrogen agonist activity evaluated for antineoplastic activity against breast cancer. (NCI04)
C28323	stage_III_cancer_of_the_uterus	Retired_Concepts	stage III cancer of the uterus	Cancer cells have spread outside the uterus to the vagina and/or lymph nodes in the pelvis but have not spread outside the pelvis.
C28324	stage_II_cancer_of_the_uterus	Retired_Concepts	stage II cancer of the uterus	Cancer that has spread to the cervix.
C28325	stage_I_cancer_of_the_uterus	Retired_Concepts	stage I cancer of the uterus	Cancer found in only the main part of the uterus, not the cervix.
C28326	stage_IV_cancer_of_the_uterus	Retired_Concepts	stage IV cancer of the uterus	Cancer cells have spread to the lining of the bladder or rectum or to distant parts of the body.
C28327	Endocervical_Carcinoma	Cervical_Carcinoma	Endocervical Carcinoma|Carcinoma of Endocervix|Carcinoma of the Endocervix
C28328	Yttrium_Y90_or_Indium_111_Labeled_Humanized_Monoclonal_Antibody_BrE-3	Radioimmunoconjugate	Yttrium Y90 (or Indium 111) labeled humanized monoclonal antibody BrE-3	Radiolabeled monoclonal antibodies consisting of a humanized BrE-3 monoclonal antibody conjugated with either Yttrium Y90 or Indium 111.  Monoclonal antibody BrE-3 binds to breast epithelial mucin, a surface antigen expressed by breast cancer cells.  Yttrium Y90 and Indium 111 are isotopes that emit beta particles.  After binding, this agent delivers beta particle-mediated cytotoxicity to breast cancer cells, leading to single strand DNA breaks.  Used in combination, these agents have both diagnostic (imaging) and therapeutic uses. (NCI)
C28329	Commercial_or_Non-CTEP_IND_agent	Retired_Concepts	Commercial or Non-CTEP IND agent
C28330	Anti-Idiotype_Specified_Monoclonal_Antibody	Monoclonal_Antibody	Anti-Idiotype Specified Monoclonal Antibody|MoAb: Anti-Idiotype Specified	A synthetic antibody produced by a genetically homogenous population of hybrid cells (hybridoma) against determinant idiotypes (Id) which usually mimic human epitopes.  Anti-Id vaccines may be effective in the treatment of B-cell lymphomas, resulting in tumor regression.  Anti-idiotype vaccine therapy is less likely to induce autoimmunity if the target antigen is not normally expressed on normal tissues.  Monoclonal antibodies have become powerful tools for tumor targeting, recognizing different protein markers on certain cancer cells and may be used alone or as delivery agents for drugs, toxins or radioactive material targeted to tumors. (NCI04)
C28332	Follicle_Centre_Lymphoma_Follicular_Grade_I_II_III_Stage_IV	Retired_Concepts	Follicle Centre Lymphoma, Follicular Grade I, II, III Stage IV	Stage IV NHL means disseminated (multifocal) involvement of one or more extralymphatic sites with or without associated lymph node involvement or isolated extralymphatic organ involvement with distant (nonregional) nodal involvement.
C28333	Pancreatic_Non-Functioning_Delta_Cell_Neoplasm	Non-Functioning_Pancreatic_Endocrine_Neoplasm|Pancreatic_Delta_Cell_Neoplasm	Non-Functioning Pancreatic Delta Cell Tumor|Non-Functioning Pancreatic Delta Cell Neoplasm	A usually malignant endocrine neoplasm arising from the delta cells of the pancreas.  It is not associated with a hormonal syndrome. -- 2005
C28334	Endothelin-1_Protein_Receptor_Antagonist	Endothelin_Receptor_Antagonist	Endothelin-1 Protein Receptor Antagonist|endothelin-1 protein receptor antagonist	A group of agents that bind to the endothelin-1 receptor (primarily endothelin-A receptor, or ET-A), thereby inhibiting tumor cell proliferation and tumor associated angiogenesis. (NCI04)
C28335	Breast_Implant	Implant	Breast Implant|breast implant	A silicone gel-filled or saline-filled sac placed under the chest muscle to restore breast shape.
C28336	Breast_Prosthesis_Implantation	Breast_Reconstruction	Breast Prosthesis Implantation	Surgical implantation of a breast prosthesis.
C28337	Stage_IV_Testicular_Non-Seminomatous_Germ_Cell_Tumor	Malignant_Testicular_Non-Seminomatous_Germ_Cell_Tumor	Stage IV Testicular Non-Seminomatous Germ Cell Tumor|Stage IV Testicular Nonseminomatous Germ Cell Tumor
C28341	Aerobic	General_Modifier	Aerobic|aerobic	In biochemistry, reactions that need oxygen to happen or happen when oxygen is present.
C28342	Alkalinization	Biochemical_Reaction	Alkalinization|alkalinization	(AL-ka-LIN-ih-ZAY-shun) The process by which a substance becomes an alkali.  An alkali is the opposite of an acid.
C28343	Allogenic	General_Modifier	Allogenic|Allogeneic|allogeneic|allogenic	Taken from different individuals of the same species.  Also called allogeneic.
C28344	Alteration	Conceptual_Entities	Alteration|alteration	A change resulting in something that is different from the original.
C28345	Angelica_Root	Nutritional_Supplement	Angelica Root|Angelica root	The root of any of a group of herbs called Angelica. It has been used in some cultures to treat certain medical problems, including gastrointestinal problems such as loss of appetite, feelings of fullness, and gas.
C28346	Control_Animal	Laboratory_Animal	Control Animal|control animals	The animals in a study that do not receive the treatment being tested.  Comparing the health of control animals with the health of treated animals allows researchers to evaluate the effects of a treatment more accurately.
C28347	Anti-inflammatory	Therapeutic_Effect	Anti-inflammatory|anti-inflammatory	Having to do with reducing inflammation.
C28348	Carcinostatic	General_Modifier	Carcinostatic|carcinostatic	(KAR-sin-o-STAT-ik) Pertaining to slowing or stopping the growth of cancer.
C28349	Cauterize	Surgical_Procedure	Cauterize|cauterize	(KOT-uh-rize) To destroy tissue with a hot instrument, an electrical current, or a caustic substance.  Used to remove spots of tumor or seal off blood vessels to stop bleeding.
C28350	Cerebellopontine	Anatomy_Modifier	Cerebellopontine|cerebellopontine	(SER-ah-BELL-o-PON-teen) Going from the cerebellum (the part of the brain responsible for coordinating movement) to the pons (part of the central nervous system located near the base of the brain).
C28351	Chiasma	Other_Anatomic_Concept	Chiasma|chiasma	(ki-AZ-ma) An anatomy term for an X-shaped crossing (for example, of nerves or tendons).
C28352	Dukes_Classification	Staging_System	Dukes' Classification|Dukes' classification	A staging system used to describe the extent of colorectal cancer. Stages range from A (early stage) to D (advanced stage).
C28353	Cordectomy	Surgical_Procedure	Cordectomy|cordectomy	(kor-DEK-tuh-mee) An operation on the vocal cords or on the spinal cord.
C28354	de_novo	General_Modifier	de novo	(dih NO-vo) In cancer, the first occurrence of cancer in the body.
C28355	Derivative	General_Modifier	Derivative|derivative	In chemistry, a compound produced from or related to another.
C28356	Tropical_Disease	Infectious_Disorder	Tropical Disease|Tropical Diseases	Infectious and parasitic diseases endemic in tropical and subtropical zones, including Chagas' disease, leishmaniasis, leprosy, malaria, onchocerciasis, schistosomiasis, sleeping sickness, yellow fever, and others; often water- or insect-borne.
C28357	Dyscrasia	Retired_Concepts	Dyscrasia|dyscrasia	Disease. Usually refers to diseases of the blood.
C28358	Extrahepatic	Anatomy_Modifier	Extrahepatic|extrahepatic	(extra-heh-PAT-ik) Located or occurring outside the liver.
C28359	Heterogeneous	General_Modifier	Heterogeneous|heterogeneous	Made up of elements or ingredients that are not alike.
C28361	Heterogenous	General_Modifier	Heterogenous|heterogenic|heterogenous	(het-er-o-JEN-ik) Derived from a different source or species.
C28362	Hypothesis	Conceptual_Entities	Hypothesis|hypothesis	A tentative proposal made to explain certain observations or facts that requires further investigation to be verified.
C28363	Immunocompetent	General_Modifier	Immunocompetent|immunocompetent	Having the ability to produce a normal immune response.
C28364	Intracavitary	General_Modifier	Intracavitary|intracavitary	Within a cavity or space, such as the abdomen, pelvis, or chest.
C28365	Irradiated	General_Modifier	Irradiated|irradiated	Treated with radiation.
C28366	Dark-Field_Microscope	Microscope	Dark-Field Microscope|dark-field microscope	A microscope (device used to magnify small objects) in which objects are lit at a very low angle from the side so that the background appears dark and the objects show up against this dark background.
C28367	Motor	Conceptual_Entities	Motor|motor	In medicine, having to do with the movement of body parts.
C28368	Nephrotoxic	General_Modifier	Nephrotoxic|nephrotoxic	Poisonous or damaging to the kidney.
C28369	Neuroepithelial	General_Modifier	Neuroepithelial|neuroepithelial	Having to do with tissue made up of sensory cells, such as tissue found in the ear, nose, and tongue.
C28370	Neurotropism	Pathologic_Process	Neurotropism|neurotropism	An ability to invade and live in neural tissue.  This term is usually used to describe the ability of viruses to infect nerve tissue.
C28371	Cold_Nodule	Nodule	Cold Nodule|cold nodule	When radioactive material is used to examine the thyroid with a scanner, nodules that collect less radioactive material than the surrounding thyroid tissue are considered "cold." A nodule that is cold does not make thyroid hormone. Cold nodules may be benign or cancerous. Cold nodules are sometimes called hypofunctioning nodules.
C28372	Hot_Nodule	Nodule	Hot Nodule|hot nodule	When radioactive material is used to examine the thyroid with a scanner, nodules that collect more radioactive material than the surrounding thyroid tissue are considered "hot." Hot nodules are rarely malignant. Hot nodules are sometimes called hyperfunctioning nodules.
C28373	Oncolytic	General_Modifier	Oncolytic|oncolytic	Refers to viruses that kill cancer cells more often than they kill normal cells.
C28374	Perioperative	General_Modifier	Perioperative|perioperative	Around the time of surgery; usually lasts from the time of going into the hospital or doctor's office for surgery until the time the patient goes home.
C28375	Phosphorous	General_Modifier	Phosphorous|phosphorous	(FOS-for-us) Having to do with or containing the element phosphorus.
C28377	Pluripotent	General_Modifier	Pluripotent|pluripotent	Able to mature or develop in any of several ways.
C28378	Proliferating	Conceptual_Entities	Proliferating|proliferating	Multiplying or increasing in number.  In biology, cell proliferation occurs by a process known as cell division.
C28380	Septate	Conceptual_Entities	Septate|septate	(SEP-tate) An organ or structure that is divided into compartments.
C28381	Sphincter	Muscle	Sphincter|sphincter	A ring-shaped muscle that relaxes or tightens to open or close a passage or opening in the body. Examples are the anal sphincter (around the opening of the anus) and the pyloric sphincter (at the lower opening of the stomach).
C28382	Hand-Foot_Syndrome	Retired_Concepts	Hand-Foot Syndrome	A condition marked by pain, swelling, numbness, tingling, or redness of the hands or feet. It sometimes occurs as a side effect of certain anticancer drugs. Also known as palmar-plantar erythodysthesia.
C28383	Totipotent	General_Modifier	Totipotent|totipotent	Having to do with cells that are able to develop into any type of cell found in the body.
C28384	Tumor_Burden	Properties_or_Attributes	Tumor Burden|tumor burden	Refers to the number of cancer cells, the size of a tumor, or the amount of cancer in the body. Also called tumor load.
C28385	Vaccinated	General_Modifier	Vaccinated|vaccinated	Treated with a vaccine.
C28386	Vasomotor	Conceptual_Entities	Vasomotor|vasomotor	Affecting the narrowing and widening of the blood vessels.
C28387	Virulent	Disease_Modifier	Virulent|virulent	Refers to the ability of a virus or a bacterium to cause damage to its host.
C28389	NCI_Administrative_Concepts	root_node	NCI Administrative Concept
C28391	B-Cell_Development	Cell_Differentiation	B-Cell Development	In mammalian bone marrow, B-Cell Development consists of progressive differentiation from CD34+ progenitor cells to plasma and memory B cells by positive/negative selection in response to local signals, including antigens and cytokines. B cell development begins with immunoglobulin gene somatic recombination and pre-B cell receptor expression. Antigen-induced signal transduction via BCR-associated ITAM molecules activates B cell proliferation. Further differentiation involves additional immunoglobulin gene recombination and expression. Antigen-stimulated circulating (resting) B cells proliferate and differentiate into plasma and memory B cell clones expressing immunoglobulins with the same antigen recognition site.
C28392	_10q23_2-q23_33	Chromosome_Band	10q23.2-q23.33	A chromosome band present on 10q
C28393	Peptidase	Retired_Concepts	Peptidase|Proteolytic Enzyme
C28394	Topical_Anti-Infective_Agent	Anti-Infective_Agent	Topical Anti-Infective Agent	A natural or synthetic agent used for local application on skin, mucosa, or cavities, a Topical Anti-Infective Agent, formulated as a sterile solution or cream, commonly displays therapeutic or prophylactic antibiotic properties against infectious viral, bacterial, or protozoal agents by inhibiting growth and survival. (NCI04)
C28395	Computed_Tomography_Colonography	Computed_Tomography	Computed Tomography Colonography|CTC|computed tomographic colonography|computed tomography colography	A method under study to examine the colon by taking a series of x-rays (called a CT scan) and then using a high-powered computer to reconstruct 2-D and 3-D pictures of the interior surfaces of the colon from these x-rays.  The pictures can be saved, manipulated to better viewing angles, and reviewed after the procedure, even years later.  Also called virtual colonoscopy.
C28396	Pancreatic_Delta_Cell_Neoplasm	Pancreatic_Endocrine_Neoplasm	Pancreatic Delta Cell Tumor|Pancreatic Delta Cell Neoplasm	A usually malignant endocrine neoplasm arising from the delta cells of the pancreas.  It may be associated with inappropriate secretion of serotonin and an associated clinical syndrome, or it may be hormonally inactive (non-functioning).
C28397	Asthma	Non-Neoplastic_Lung_Disorder	Asthma
C28398	Allied_Health_Profession	Occupation	Allied Health Profession
C28400	CASP10_Gene	Caspase_Gene	CASP10 Gene|ALPS2|Apoptotic Protease MCH-4 Gene|CASP10|Caspase 10, Apoptosis-Related Cysteine Protease Gene|Caspase-10 Gene|FADD-Like ICE2 Gene|FAS-Associated Death Domain Protein Interleukin-1B-Converting Enzyme 2 Gene|FLICE2|Fas-Associated Death Domain Protein Gene|ICE-Like Apoptotic Protease 4 Gene|Interleukin-1B-Converting Enzyme 2 Gene|MCH4	The CASP10 gene at 2q33-q34 encodes Caspase-10, a member protein of the cysteine-aspartic acid protease (caspase) family. Caspases exist as inactive proenzymes that undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspase-10 is involved in the activation cascade of caspases responsible for apoptosis execution. It is recruited to both FAS- and TNFR-1 receptors in a FADD dependent manner. Caspase-10 cleaves and activates Caspases-3, -4, -6, -7, -8, and -9, and itself can be processed by Caspase-8. Mutations in the CASP10 gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Four alternatively spliced transcript variants encoding different isoforms have been described for this gene. (From LocusLink, Swiss-Prot and NCI)
C28401	Olfactory_Bulb	Brain_Part	Olfactory Bulb
C28402	Primitive_Streak	Other_Embryologic_Structure	Primitive Streak
C28404	Cysteine_Protease_Gene	Protease_Gene	Cysteine Protease Gene|Thiol Protease Gene	Cysteine Protease Genes encode endopeptidases, inactivated by sulfhydryl reagents, that have a cysteine residue involved in the catalytic process. (NCI)
C28405	CTSB_Gene	Cysteine_Protease_Gene	CTSB Gene|APPS|CPSB|CTSB|Cathepsin B Gene	The CTSB Gene at 8p22 encodes Cathepsin B, a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of Cathepsin B has been associated with esophageal adenocarcinoma and other tumors. Tumors with overexpression of cathepsins have powerful potential for invasiveness in the early stage of gastric carcinoma. Gastric carcinoma cells that oversecrete cathepsins B have a high invasive and metastatic potential. At least five transcript variants encoding the same protein have been found for this gene. (From LocusLink, PMID 10931446 and NCI)
C28406	CTSD_Gene	Protease_Gene	CTSD Gene|CPSD|CTSD|Cathepsin D (Lysosomal Aspartyl Protease) Gene|MGC2311	The CTSD Gene at 11p15.5 encodes Cathepsin D, which is a lysosomal aspartyl protease composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It has a specificity similar to but narrower than that of pepsin A, decomposing cytoplasmic proteins, cell organelles, collagen, elastase and proteoglycans. Cathepsin D takes part in angiogenesis and activates osteoclasts, and plays a major role in the destruction of bone tissue by cholesteatoma. Transcription of the CTSD gene is initiated from several sites, including one which is a start site for an estrogen-regulated transcript. Mutations in this gene are involved in the pathogenesis of several diseases, including breast and ovarian cancer, and possibly Alzheimer disease. (From LocusLink, PMID 12185597 and NCI)
C28407	National_Origin	Personal_Attribute	National Origin	System of classification based on nation from which a person originates, regardless of the nation in which he/she currently resides. (Diversity Dictionary: http://www.inform.umd.edu/EdRes/Topic/Diversity/Reference/divdic.html)
C28408	Quantitative_Reverse_Transcriptase_PCR	RT-PCR	Quantitative Reverse Transcriptase PCR|Quantitative RTPCR|qRTPCR	Quantitative PCR: a method to measure very small amounts of RNA transcripts as cDNA targets. There are two strategies currently used, one is called Competitive RTPCR and the other is called Real-Time PCR.
C28409	Chloroacetate_Esterase_Staining_Method	Special_Histology_Staining_Method	Chloroacetate Esterase Staining Method|Chloroacetate Esterase Stain|Leder Stain	Chloroacetate esterase (CAE) is a cytochemical staining technique to specifically identify cells of the granulocyte lineage, from the early promyelocyte stage to mature neutrophils.
C28411	Aspartyl_Protease	Protease	Aspartyl Protease|Aspartic Protease	Aspartyl Proteases (Aspartic Endopeptidases) have an acidic residue (aspartate) involved in the catalytic process, have a pH optimum below 5 and catalyze the cleavage of internal peptide bonds in a polypeptide or protein.
C28414	Wilson_s_Staining_Method	Special_Histology_Staining_Method	Wilson's Staining Method|Modified Wright Stain|Wilson's Stain|Wison's Stain|Wison's Staining Method	An immunohistochemical staining method to identify copper deposits in the liver, such as in Wilson's Disease, which is a genetic disorder of copper overload.(NCI2005)
C28415	Synaptophysin_and_Hematoxylin_Staining_Method	Special_Histology_Staining_Method	Synaptophysin and Hematoxylin Staining Method|Synaptophysin|Synaptophysin and Hematoxylin	Samples counterstained with hematoxylin following Synaptophysin staining.(NCI2005)
C28416	Alpha_Naphthyl_Butyrate_Esterase_Staining_Method	Alpha_Naphthyl_Esterase_Staining_Method	Alpha Naphthyl Butyrate Esterase Staining Method|Alpha Naphthyl Butyrate Esterase Stain	A cytochemical staining technique to detect esterase enzyme contained within monocytes and macrophages, which reacts strongly with the substrate alpha-naphthyl butyrate. Monoblastic [FAB M5a (without differentiation) or M5b (with differentiation)] and acute myelomonocytic (M4) leukemias have staining in blasts when the butyrate substrate is employed. Myeloid cells (either malignant or non-malignant) do not stain with nonspecific esterase techniques.
C28417	Alpha_Naphthyl_Acetate_Esterase_Staining_Method	Alpha_Naphthyl_Esterase_Staining_Method	Alpha Naphthyl Acetate Esterase Staining Method|Alpha Naphthyl Acetate Esterase Stain	A cytochemical staining technique to detect alpha-naphthyl acetate esterase (ANAE) activity. Nonspecific esterase stains with acetate substrate and is mainly used in the determination of lineage in acute myelogenous leukemia. Acute megakaryoblastic leukemia (M7) blasts stain strongly when the acetate substrate is used.
C28418	Somatostatin	Hypothalmic_Hormone	Somatostatin|AY 24910|Growth Hormone Release Inhibiting Factor|Growth Hormone-Inhibiting Hormone|Panhibin|SST|Somatotropin Release Inhibiting Factors	Expressed primarily by human SST Gene (Somatostatin Family) in the hypothalamic median eminence and in pancreatic delta cells, secreted 116-aa 13-kDa (precursor) Somatostatin is an important cyclic tetradecapeptide regulator of endocrine and nervous system function. Somatostatin inhibits release of adenohypophyseal GH, thyrotropin, and corticotropin, pancreatic insulin and glucagon, gastric mucosal gastrin, intestinal mucosal secretin, and renal renin by binding to specific high-affinity cell surface G protein-coupled receptors expressed in a tissue-specific manner. (NCI)
C28419	Growth_Hormone-Releasing_Hormone	Hypothalmic_Hormone	Growth Hormone Releasing Hormone|GHRH|Growth Hormone-Releasing Hormone|Sermorelin|Somatocrinin|Somatoliberin	This protein belongs to the glucagon family and is a preproprotein that is produced in the hypothalamus. The preproprotein is cleaved to form a 44 aa factor, also called somatocrinin, that acts to stimulate growth hormone release from the pituitary. Variant receptors for somatocrinin have been found in several types of tumors, and antagonists of these receptors can inhibit the growth of the tumors. Defects in the gene are a cause of dwarfism, while hypersecretion of the encoded protein is a cause of gigantism. (from RefSeq)
C28420	Thyrotropin-Releasing_Hormone	Hypothalmic_Hormone	Thyrotropin Releasing Hormone|Protirelin|TRH|Thyroid Releasing Hormone|Thyroid-Releasing Hormone|Thyroliberin|Thyrotropin-Releasing Hormone	Expressed (highest) in the medial hypothalamic paraventricular nuclei and median eminence by human TRH Gene, 242-aa 27-kDa (precursor) (prepro-)Thyrotropin-Releasing Hormone is a major regulator of TSH biosynthesis and release in the anterior pituitary gland and neurotransmitter/neuromodulator in the central and peripheral nervous systems. (NCI)
C28421	Sex	Personal_Attribute	Sex	The assemblage of physical properties or qualities by which male is distinguished from female; the physical difference between male and female; the distinguishing peculiarity of male or female. (from On-line Medical Dictionary)
C28422	Inbred_Strain	Laboratory_Animal	Inbred Strain	A strain that has been maintained by sibling (sister x brother) matings for 20 or more consecutive generations. (from JAX Strain Information)
C28424	CASP9_Gene	Caspase_Gene	CASP9 Gene|APAF-3|APAF3|Apoptotic Protease Activating Factor 3 Gene|Apoptotic Protease MCH-6 Gene|CASP-9|CASP9|Caspase 9 Gene|Caspase 9, Apoptosis-Related Cysteine Protease Gene|Caspase-9 Gene|ICE-LAP6 Gene|ICE-Like Apoptotic Protease 6 Gene|MCH6	The CASP9 Gene at 1p36.3-p36.1 encodes Caspase-9. Caspase-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP. Caspase-9 and APAF1 bind to each other in the presence of cytochrome c and dATP, an event that leads to caspase-9 activation. Activation of procaspase-9 by APAF1 requires proteolytic cleavage to generate the mature caspase molecule. Activated caspase-9 in turn cleaves and activates caspase-3. APAF1-mediated processing of procaspase-9 occurs at asp315 by an intrinsic autocatalytic activity of procaspase-9 itself. APAF1 can form oligomers and may facilitate procaspase-9 autoactivation by oligomerizing its precursor molecules. Once activated, caspase-9 can initiate a biochemical cascade involving the downstream executioners caspase-3, -6, and -7. Alternative splicing of this gene results in two transcript variants which encode different isoforms. (From LocusLink, OMIM and NCI)
C28425	_1p36_3-p36_1	Chromosome_Band	1p36.3-p36.1	A chromosome band present on 1p
C28427	Caspase-9	Caspase	Caspase-9|APAF-3|APAF3|Apoptotic Protease Activating Factor 3|Apoptotic Protease MCH-6|CASP-9|CASP9|CASP9 Protein|Caspase 9, Apoptosis-Related Cysteine Protease|EC 3.4.22.-|ICE-LAP6|ICE-Like Apoptotic Protease 6|MCH6	Caspase-9 is encoded by the CASP9 Gene. Caspase-9 is the most upstream member of the apoptotic protease cascade that is triggered by cytochrome c and dATP. Caspase-9 and APAF1 bind to each other in the presence of cytochrome c and dATP, an event that leads to caspase-9 activation. Activation of procaspase-9 by APAF1 requires proteolytic cleavage to generate the mature caspase molecule. Activated caspase-9 in turn cleaves and activates caspase-3. APAF1-mediated processing of procaspase-9 occurs at asp315 by an intrinsic autocatalytic activity of procaspase-9 itself. APAF1 can form oligomers and may facilitate procaspase-9 autoactivation by oligomerizing its precursor molecules. Once activated, caspase-9 can initiate a biochemical cascade involving the downstream executioners caspase-3, -6, and -7. Alternative splicing of this gene results in two transcript variants which encode different isoforms. (From LocusLink, OMIM and NCI)
C28428	Retired_Concepts	root_node	Retired Concept|All Retired Concepts|Retired Concepts|isRetired	Concept has been retired, and should not be used except to deal with old data.
C28429	CASP4_Gene	Caspase_Gene	CASP4 Gene|Apoptotic Cysteine Protease Mih1/TX Gene|CASP-4|CASP4|Caspase 4 Gene|Caspase 4, Apoptosis-Related Cysteine Protease Gene|Caspase-4 Gene|ICE(rel)II Gene|ICErel-II Gene|ICH-2|Mih1/TX Gene|TX|TX Protease Gene	The CASP4 Gene at 11q22.2-q22.3 encodes Caspase-4, a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. Caspase-4 is able to cleave and activate its own, as well as caspase 1, precursor proteins. When overexpressed, this gene has been shown to induce cell apoptosis. Alternative splicing results in 3 transcript variants encoding distinct isoforms. (From LocusLink and NCI)
C28430	_11q22_2-q22_3	Chromosome_Band	11q22.2-q22.3	A chromosome band present on 11q
C28431	Caspase-4	Caspase	Caspase-4|Apoptotic Cysteine Protease Mih1/TX|CASP-4|CASP4|CASP4 Protein|Caspase 4, Apoptosis-Related Cysteine Protease|EC 3.4.22.-|ICE(rel)II|ICErel-II|ICH-2|Mih1/TX|TX|TX Protease	Caspase-4, encoded by the CASP4 Gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. Caspase-4 is able to cleave and activate its own, as well as caspase 1, precursor proteins. When overexpressed, this gene has been shown to induce cell apoptosis. Alternative splicing results in 3 transcript variants encoding distinct isoforms. (From LocusLink and NCI)
C28432	Nipple_Carcinoma	Breast_Carcinoma|Malignant_Nipple_Neoplasm	Nipple Carcinoma
C28433	CASP5_Gene	Caspase_Gene	CASP5 Gene|CASP5|Caspase 5 Gene|Caspase 5, Apoptosis-Related Gene|Caspase-5 Gene|Cysteine Protease Gene|ICE(rel)-III Gene|ICH-3 Protease Gene|ICH3|TY Protease Gene	The CASP5 Gene at 11q22.2-q22.3 encodes Caspase-5, a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme has been shown to induce apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein, which required Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. (From LocusLink and NCI)
C28434	Caspase-5	Caspase	Caspase-5|CASP5|CASP5 Protein|Caspase 5, Apoptosis-Related Cysteine Protease|Cysteine Protease|EC 3.4.22.-|ICE(rel)-III|ICH-3 Protease|ICH3|TY Protease	Caspase-5, encoded by the CASP5 Gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme has been shown to induce apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein, which required Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. (From LocusLink and NCI)
C28435	CASP6_Gene	Caspase_Gene	CASP6 Gene|Apoptotic Cysteine Protease MCH2 Gene|Apoptotic Protease MCH-2 Gene|CASP6|CASPASE 6, Apoptosis-Related Cysteine Protease Gene|Caspase 6 Gene|Caspase-6 Gene|MCH2	The CASP6 Gene at 4q25 encodes Caspase-6, a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Caspase-6 can be processed by caspases 7, 8 and 10, and functions as a downstream enzyme in the activation cascade of caspases responsible for apoptosis execution. It cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Alternative splicing of this gene results in two transcript variants which encode different isoforms. Its overexpression promotes programmed cell death. (From LocusLink, Swiss-Prot and NCI)
C28436	Caspase-6	Caspase	Caspase-6|Apoptotic Cysteine Protease MCH2|Apoptotic Protease Mch-2|CASP6|CASP6 Protein|CASPASE 6, Apoptosis-Related Cysteine Protease|EC 3.4.22.-|MCH2	Caspase-6, encoded by the CASP6 Gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. Caspase-6 can be processed by caspases 7, 8 and 10, and functions as a downstream enzyme in the activation cascade of caspases responsible for apoptosis execution. It cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Alternative splicing of this gene results in two transcript variants which encode different isoforms. Its overexpression promotes programmed cell death. (From LocusLink, Swiss-Prot and NCI)
C28437	_5p13_2	Chromosome_Band	5p13.2	A chromosome band present on 5p
C28438	CASP7_Gene	Caspase_Gene	CASP7 Gene|Apoptotic Protease MCH-3 Gene|CASP7|CMH-1|Caspase 7 Gene|Caspase 7, Apoptosis-Related Cysteine Protease Gene|Caspase-7 Gene|ICE-LAP3 Gene|ICE-Like Apoptotic Protease 3 Gene|MCH3	The CASP7 Gene at 10q25 encodes Caspase-7, a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase can be cleaved by caspase 3 and 10. It has been shown to be activated upon cell death stimuli and induce apoptosis. Alternative splicing of this gene results in 4 transcript variants, which encode 3 distinct isoforms. (From LocusLink and NCI)
C28439	Caspase-7	Caspase	Caspase-7|Apoptotic Protease Mch-3|CASP7|CASP7 protein|CMH-1|Caspase 7|Caspase 7, Apoptosis-Related Cysteine Protease|EC 3.4.22.-|ICE-LAP3|ICE-Like Apoptotic Protease 3|MCH3	Caspase-7, encoded by the CASP7 Gene, is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase can be cleaved by caspase 3 and 10. It has been shown to be activated upon cell death stimuli and induce apoptosis. Alternative splicing of this gene results in 4 transcript variants, which encode 3 distinct isoforms. (From LocusLink and NCI)
C28440	Small_Nuclear_Ribonucleoprotein_Particle	Protein_or_Riboprotein_Complex	Small Nuclear Ribonucleoprotein Particle|Small Nuclear RNP|snRNP	Highly conserved small nuclear RNA-protein complexes that mediate splicing of hnRNP to mRNA, pre-mRNA 3'-end processing in the nucleoplasm, and pre-rRNA processing in the nucleolus. Small nuclear ribonuclear proteins draw together specific hnRNA sequences to form a loop that is then excised.
C28441	Alpha_Naphthyl_Esterase_Staining_Method	Special_Histology_Staining_Method	Alpha Naphthyl Esterase Staining Method|Alpha Naphthyl Butyrate Esterase Stain|Alpha Naphthyl Esterase Stain	Alpha Naphthyl Esterase staining method or nonspecific esterase staining is used for identification and quantitation of monoblasts and monocytes. This cytochemical staining technique detects esterase activity. The esterase enzyme contained within monocytes and macrophages reacts strongly with the substrate alpha-naphthyl butyrate. The test is useful in diagnosis of acute leukemias. It marks immature monocytes, and thus is useful in diagnosis of acute myelogenous leukemia of monocytic type.
C28442	EPO_Gene	Colony-Stimulating_Factor_Gene	EPO Gene|EP|EPO|Erythropoietin Gene	This gene encodes human erythropoietin, an acidic glycoprotein hormone with a molecular mass of 34 kD. As the prime regulator of red cell production, its major functions are to promote erythroid differentiation and to initiate hemoglobin synthesis.[supplied by OMIM](LocusLink)
C28443	Chromosomal_Nondisjunction	Retired_Concepts	Chromosomal Nondisjunction|Chromosomal Non-disjunction|Chromosome Nondisjunction|Nondisjunction	The failure of the chromosomes to disjoin and move to opposite poles.
C28444	Reciprocal_Translocation	Chromosomal_Translocation	Reciprocal Translocation
C28445	Paracentric_Inversion	Chromosomal_Inversion	Paracentric Inversion
C28446	Pericentric_Inversion	Chromosomal_Inversion	Pericentric Inversion
C28447	Robertsonian_Translocation	Chromosomal_Translocation	Robertsonian Translocation	A translocation in which the centromeres of two chromosomes are fused, forming a chromosome consisting of the long arms of two different chromosomes. -- 2003
C28448	Meiotic_Nondisjunction	Retired_Concepts	Meiotic Nondisjunction	The failure of the chromosomes to disjoin and move to opposite poles, may affect as many as 25% of all ova and 2% of all sperm. Half of these abnormal gametes are nullisomy, half are disomy. Two copies of a chromosome pass into the same gamete, leaving the other gamete as nullisomy. 95% of the Down Syndrome birth were result of meiotic disjunction.
C28449	Mitotic_Nondisjunction	Retired_Concepts	Mitotic Nondisjunction	The failure of the chromosomes to disjoin and move to opposite poles during mitosis, by which could result in mosaic individual.
C28450	Tetraploidy	Polyploidy	Tetraploidy
C28451	CSF1_Gene	Colony-Stimulating_Factor_Gene	CSF1 Gene|CSF1|Colony Stimulating Factor 1 (Macrophage) Gene|MCSF|MGC31930	The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. It may also be involved in development of the placenta. (from LocusLink)
C28452	Philadelphia_Chromosome	Chromosomal_Aberration	Philadelphia Chromosome|Philadelphia chromosome	An abnormality of chromosome 22 in which part of chromosome 9 is transferred to it.  Bone marrow cells that contain the Philadelphia chromosome are often found in chronic myelogenous leukemia.
C28453	Aberrant_Chromosome	Retired_Concepts	Aberrant Chromosome
C28454	hnRNA	Gene_Product	hnRNA|Heterogeneous Nuclear RNA|Pre-mRNA	The name originally given to large RNA molecules found in the nucleus, which are now known to be unedited messenger RNA transcripts, or pre-mRNAs. (BioTech Life Science Dictionary)
C28455	Ultrasonogram	Medical_Image	Ultrasonogram|Sonogram|sonogram|ultrasonogram	(SON-o-gram) A computer picture of areas inside the body created when sound waves bounce off organs and other tissues.
C28459	Oxygenase	Oxidoreductase	Oxygenase	Enzymes acting on single donors with incorporation of molecular oxygen. EC 1.13.-
C28460	Subcellular_Anatomy	Other_Anatomic_Concept	Subcellular Anatomy|Cell Anatomy|Cellular Anatomy
C28461	CTSL_Gene	Cysteine_Protease_Gene	CTSL Gene|CATL Gene|CTSL|Cathepsin L Gene|MEP Gene|Major Excreted Protein Gene	The CTSL Gene at 9q21-q22 encodes Cathepsin L, a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. Cathepsin L has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. Cathepsin L is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. At least two transcript variants encoding the same protein have been found for this gene. (From LocusLink and NCI)
C28462	_9q21-q22	Chromosome_Band	9q21-q22	A chromosome band present on 9q
C28463	CTSH_Gene	Cysteine_Protease_Gene	CTSH Gene|Aleurain Gene|CPSB Gene|CTSH|Cathepsin B3 Gene|Cathepsin BA Gene|Cathepsin H Gene|MGC1519 Gene|N-Benzoylarginine-Beta-Naphthylamide Hydrolase Gene	The CTSH Gene at 15q24-q25 encodes Cathepsin H, which is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. Cathepsin H is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. Cathepsin H can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene. (From LocusLink and NCI)
C28464	_5p13_1-p12	Chromosome_Band	5p13.1-p12	A chromosome band present on 5p
C28465	GDNF_Gene	Growth_Factor_Gene	GDNF Gene|GDNF|Glial Cell Derived Neurotrophic Factor Gene	Human GDNF Gene at 5p13.1-p12 encodes homodimeric secreted Glial Cell-Line Derived Neurotrophic Factor, a ligand for the RET receptor tyrosine kinase and containing 7 conserved cysteines spaced similar to TGF-Bs. GDNF promotes survival and differentiation of dopaminergic neurons, rescues motor neurons from programmed cell death, and protects cells from the neurotoxin MPTP. (NCI)
C28466	Neurturin	Transforming_Growth_Factor-Beta	Neurturin|NRTN	Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. (LocusLink)
C28467	Macrophage_Migration_Inhibitory_Factor	Lymphokine	Macrophage Migration Inhibitory Factor|Glycosylation-Inhibiting Factor|MIF|Phenylpyruvate Tautomerase	This protein is a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. (from Locuslink)
C28468	Small_Inducible_Cytokine-B9	Alpha_Chemokine	Small Inducible Cytokine B9|CXCL9|Chemokine (C-X-C Motif) Ligand 1|Monokine Induced by Gamma Interferon	Induced by INF gamma and encoded by human CXCL9 Gene (Intercrine Alpha/Chemokine CXC Family), secreted 125-aa 14-kD (precursor) chemoattractant (T-cells) Small Inducible Cytokine B9 binds to CXCR3 and is involved in angiogenesis and T-cell activation in inflammatory responses. (NCI)
C28469	F7_Gene	Coagulation_Factor_Gene	F7 Gene|Coagulation Factor VII (Serum Prothrombin Conversion Accelerator) Gene|F7|FA7	Human F7 Gene (Peptidase S1 Family) encodes 466-aa 51.6-kDa (precursor) Coagulation Factor VII, a heat-stable vitamin K-dependent serum clotting factor for hemostasis that contains 2 EGF-like domains and circulates as a zymogen. Glutamate carboxylation allows the protein to bind calcium. Proteolytically converted by factor IXa, factor Xa, factor XIIa, or thrombin, heterodimeric active factor VIIa contains a catalytic heavy chain disulfide-linked to a light chain containing 2 EGF-like domains. With and activated by tissue factor III and calcium, activated factor VIIa activates the coagulation cascade by converting/activating factor IX to factor IXa and/or factor X to factor Xa by limited proteolysis of an Arg-Ile bond. F7 defects can cause coagulopathy. (NCI)
C28470	F8_Gene	Coagulation_Factor_Gene	F8 Gene|AHF|Coagulation Factor VIII, Procoagulant Component (Hemophilia A) Gene|DXS1253E|F8|F8B|F8C|FVIII|HEMA	Expressed in the liver, human F8 Gene encodes 2351-aa 267-kDa (precursor) Coagulation Factor VIII, an extracellular antihemophilic factor with strong similarity to Coagulation Factor V that contains 3 F5/8 type A domains and 2 F5/8 type C domains and acts in the intrinsic blood coagulation pathway. Essential for Factor VIII activity, the F5/8 Type C 2 domain is responsible for phospholipid-binding. Alternative transcript Variant 1 encodes large glycoprotein isoform A that circulates in plasma noncovalently associated with von Willebrand factor and undergoes multiple cleavage events. Transcript Variant 2 encodes small isoform B consisting primarily of the Factor VIIIc phospholipid binding domain. Factor VIII acts as a cofactor (enhanced by thrombin) for Factor IXa, which, with Ca+2 and phospholipids, converts Factor X to activated Xa. F8 defects cause of hemophilia A. (NCI)
C28471	Inhibin_Alpha	Protein_Complex_Subunit	Inhibin Alpha|Alpha Inhibin|INHA	The inhibin alpha subunit joins either the beta A or beta B subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. However, in prostate cancer, expression of the inhibin alpha-subunit gene was suppressed and was not detectable in poorly differentiated tumor cells. Furthermore, because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. (LocusLink)
C28472	Inhibin_Beta-A	Protein_Complex_Subunit	Inhibin Beta A|Activin A|Activin AB Alpha|INHBA	The inhibin beta A subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta A subunit forms a homodimer, activin A, and also joins with a beta B subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. (from LocusLink)
C28473	Inhibin_Beta-B	Protein_Complex_Subunit	Inhibin Beta B|Activin AB Beta|Beta-2 Inhibin|INHBB|Inhibin Beta-2	The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumor-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. (LocusLink)
C28474	Insulin_Receptor_Substrate-1	Adaptor_Signaling_Protein	Insulin Receptor Substrate 1|IRS1	The protein IRS1 acts as an interface between signaling proteins with Src homology-2 domains (SH2 proteins) and the receptors for insulin, IGF2, growth hormone, several interleukins (IL4, IL9, IL13), and other cytokines. It regulates gene expression and stimulates mitogenesis and appears to mediate insulin/IGF1-stimulated glucose transport. (from OMIM 600797)
C28475	Insulin_Receptor_Substrate-2	Adaptor_Signaling_Protein	Insulin Receptor Substrate 2|IRS2	Similar in function to IRS1; insulin receptor substrate 2 is a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS2 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS2 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin-4 receptor (IL4R) -associated kinase in response to IL4 treatment. (LocusLink)
C28476	Insulin_Receptor_Substrate-4	Adaptor_Signaling_Protein	Insulin Receptor Substrate 4|IRS4	Similar in function to IRS1 and IRS2; insulin receptor substrate 4 is a cytoplasmic protein that contains many potential tyrosine and serine/threonine phosphorylation sites. Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains. The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation.(LocusLink)
C28480	Coagulation_Factor_Gene	Ligand_Binding_Protein_Gene	Coagulation Factor Gene	Coagulation Factor Genes encode endogenous Coagulation Factors, involved in blood coagulation. (NCI)
C28481	F9_Gene	Coagulation_Factor_Gene	F9 Gene|Coagulation Factor IX (Plasma Thromboplastic Component, Christmas Disease, Hemophilia B) Gene|F9|FIX|HEMB|PTC	Expressed primarily in the liver, human F9 Gene (Peptidase S1 Family) encodes 461-aa 52-kDa (precursor) Coagulation Factor IX, a vitamin K-dependent plasma protein involved in the intrinsic blood coagulation cascade that contains 2 EGF-like domains and circulates as an inactive zymogen. Gamma-carboxyglutamic acid residues bind calcium. Factor IX is converted to active form by Factor XIa, which excises the activation peptide and generates the disulfide-bound light and heavy chains. Through interaction with Ca(2+), membrane phospholipids, and Factor VIIIa, activated Factor IX converts Factor X to its active Xa form by hydrolyzing one Arg-Ile bond. F9 point mutation, insertion, and deletion defects cause hemophilia B. (NCI)
C28482	Coagulation_Factor-IX	Coagulation_Factor	Coagulation Factor IX|Christmas Factor|EC 3.4.21.22|F9|Factor IX	Factor ix is a vitamin k-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor x to its active form in the presence of ca(2+) ions, phospholipids, and factor VIIIa.
C28483	VWF_Gene	Coagulation_Factor_Gene	VWF Gene|F8VWF|VWD|VWF|Von Willebrand Factor Gene	The glycoprotein encoded by this gene functions as both an antihemophilic factor carrier and a platelet-vessel wall mediator in the blood coagulation system. It is crucial to the hemostasis process. Mutations in this gene or deficiencies in this protein result in von Willebrand's disease. An unprocessed pseudogene has been found on chromosome 22. (LocusLink)
C28484	_12p13_3	Chromosome_Band	12p13.3	A chromosome band present on 12p
C28485	Kallikrein-15_Protein	Kallikrein	Kallikrein 15|ACO Protease|EC 3.4.21.-|KLK15|Kallikrein-Like Serine Protease|Prostinogen	Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, this gene has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. (from LocusLink)
C28486	Cell_Movement	Cell_Movement_Process	Cell Movement	Cell Movement involves translocation of a whole cell, or cell body, from one site to another; distinct from cell motion that involves movement of cell processes (e.g., axons, microvilli, etc.). (NCI)
C28487	_8q21_12	Chromosome_Band	8q21.12	A chromosome band present on 8q
C28488	_7q31_1-q31_2	Chromosome_Band	7q31.1-q31.2	A chromosome band present on 7q
C28489	Integrin_Beta-2	Cell_Adhesion_Molecule	Integrin Beta-2|Beta 2 Integrin Chain|CD11a Beta Subunit|CD11b Beta Subunit|CD11c Beta Subunit|CD18 Antigen|ITGB2|LFA-1/CR3/P150, 959 Beta Subunit Precursor|Lymphocyte Function-Associated Cell Surface Adhesion Glycoprotein	Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGB2 encodes the integrin beta 2 chain. Mutations in the beta-2 subunit of the leukocyte cell adhesion molecule have been found to cause the autosomal recessive disorder of neutrophil function known as leukocyte adhesion deficiency(from LocusLink)
C28490	Integrin_Beta-4	Cell_Adhesion_Molecule	Integrin Beta-4|ITGB4	Integrins are transmembrane glycoprotein receptors that mediate cell-matrix or cell-cell adhesion, and transduce signals that regulate gene expression and cell growth. They are heterodimeric molecules consisting of noncovalently linked alpha and beta subunits. All integrin subunits display a cytoplasmic domain that interacts with the cytoskeleton, a transmembrane region, and a large extracellular domain that interacts with the extracellular matrix. The ITGB4 extracellular domain shows 35% identify with other integrin beta subunits, but is the most different among this class of molecules. The transmembrane region is poorly conserved, whereas the cytoplasmic domain showed no substantial identity in any region to the cytoplasmic tails of other integrin beta sequences or to other protein sequences. The integrin alpha-6/beta-4, a receptor for the laminins, is likely to play a pivotal role in the biology of invasive carcinoma. (from OMIM)
C28491	Cellular_Infiltration	Multicellular_Process	Cellular Infiltration	Cellular Infiltration involves normal or pathologic migration and accumulation of cells within tissues.
C28492	Janus_Kinase-3	Protein_Tyrosine_Kinase	Janus Kinase 3|JAK3	This protein is a member of janus family. JAK3 functions in signal transduction and interacts with members of the STAT (signal transduction and activators of transcription) family. JAK3 is predominantly expressed in immune cells and transduces a signal in response to its activation via tyrosine phosphorylation by interleukin receptors. Mutations that abrogate janus kinase 3 function cause an autosomal SCID (severe combined immunodeficiency disease). (from LocusLink)
C28493	Janus_Kinase-1	Protein_Tyrosine_Kinase	Janus Kinase 1|EC 2.7.1.112|JAK1|Tyrosine-Protein Kinase JAK1	Janus kinase 1 (JAK1), is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. JAK1 is a large, widely expressed membrane-associated phosphoprotein. It is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. (from LocusLink)
C28494	Janus_Kinase-2	Protein_Tyrosine_Kinase	Janus Kinase 2|EC 2.7.1.112|JAK-2|JAK2|Tyrosine-Protein Kinase JAK2	This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. (from LocusLink)
C28495	Motivation	Mental_Process	Motivation	The psychological feature that arouses an organism to action toward a desired goal; the reason for the action; that which gives purpose and direction to behavior.
C28496	Vascular_Endothelial_Growth_Factor_Receptor-2	Vascular_Endothelial_Growth_Factor_Receptor	Vascular Endothelial Growth Factor Receptor 2|EC 2.7.1.112|KDR|Kinase Insert Domain Receptor|Kinase Insert Domain Receptor (A Type III Receptor Tyrosine Kinase)|Protein-Tyrosine Kinase Receptor Flk-1|VEGFR-2	Receptor for vegf or vegf-c. Has a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. (from SwissProt)
C28498	Biochemical_Process	Subcellular_Process	Biochemical Process	A linked series of non-equivalent biochemical interactions and enzymatic reactions, and/or a linked series of biochemical processes.
C28499	Manic_Fringe_Protein	Signaling_Protein	Manic Fringe|MFNG	This protein is a member of the fringe family which also includes Radical and Lunatic fringe. They are evolutionarily conserved secreted proteins that participate in the Notch signaling pathway in determining boundaries during segmentation and cell fates during neurogenesis. (from LocusLink and OMIM)
C28500	Iodinated_Contrast_Dye	Contrast_Agent	Iodinated Contrast Dye	A contrast agent containing an iodine-based dye used in many diagnostic imaging examinations, including computed tomography, angiography, and myelography.(NCI)
C28501	Wobe-Mugos_E	Cytoprotective_Agent|Miscellaneous_Adjuvant	Wobe-Mugos E	A poly-enzymatic formulation containing three proteolytic enzymes, papain, trypsin, and chymotrypsin, used as an adjuvant in chemotherapy to modulate dendritic cells and tumor-associated macrophages. (NCI)
C28502	Bismuth_Bi213_Monoclonal_Antibody_M195	Radioimmunoconjugate	Bismuth Bi213 Monoclonal Antibody M195	A radioimmunoconjugate consisting of murine monoclonal antibody (M195) and bismuth 213 (Bi213).  Monoclonal antibody M195 binds to CD33, a surface antigen expressed by myelogenous leukemia cells.  Bismuth 213 is an isotope that emits short-ranged high-energy alpha particles.  This radioimmunoconjugate selectively delivers alpha particle-mediated cytotoxicity to leukemic cells, thereby limiting the exposure of normal tissues to ionizing radiation. (NCI04)
C28503	Globo_H-GM2-Lewis-y-MUC1-32-mer-TF_c_Tn_c_KLH_Conjugate_Vaccine	Antineoplastic_Vaccine	Globo H-GM2-Lewis-y-MUC1-32-mer-TF(c)-Tn(c)-KLH Conjugate Vaccine	A multivalent vaccine comprised of Globo H (Globo H Hexasaccharide 1), GM2, Lewis-y, MUC1-32-mer, TF(c), and Tn(c) antigens conjugated with Keyhole Limpet Hemocyanin, an immunomodulator.  This vaccine may induce the production of IgG and IgM antibodies and an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumors expressing these antigens. (NCI)
C28504	Globo-H-GM2-Lewis-y-MUC1-32-mer-TF_c_Tn_c_KLH-Conjugate-Vaccine_QS21	Chemotherapy_Regimen	Globo H-GM2-Lewis-y-MUC1-32-mer-TF(c)-Tn(c)-KLH Conjugate Vaccine/QS21	A multivalent vaccine comprised of Globo H (Globo H Hexasaccharide 1), GM2, Lewis-y, MUC1-32-mer, TF(c), and Tn(c) antigens conjugated with Keyhole Limpet Hemocyanin, an immunomodulator, plus QS21, an immune enhancer. (NCI)
C28505	Ion_Channel_Protein	Transport_Protein	Ion Channel Protein	Ion Channel Proteins typically aggregate in membrane-associated complexes forming pores whose activities regulate the movement of ions through cellular membranes to affect cellular homeostatic conditions and/or signaling processes. (NCI)
C28506	Nuclear_Translocation	Subcellular_Protein_Targeting	Nuclear Translocation	Nuclear Translocation is a subcellular process in which activated cytoplasmic proteins are transported into the cell nucleus as part of a signal transduction pathway to modify cell function (typically gene expression) in response to a signaling event or condition.
C28507	Transport_Reaction	Biochemical_Reaction	Transport Reaction	A Transport Reaction consists of a biochemical reaction directly involved in the physical translocation of a biological molecule from one site or compartment to another.
C28508	Interleukin-12A	Protein_Complex_Subunit	Interleukin-12A|CLMF|CLMF p35|Cytotoxic Lymphocyte Maturation Factor|Cytotoxic Lymphocyte Maturation Factor 1, p35|Cytotoxic Lymphocyte Maturation Factor 35 kDa Subunit|IL-12, subunit p35|IL-12A|IL12, Subunit P35|IL12A|IL12A Protein|Interleukin 12A|Interleukin 12A (Natural Killer Cell Stimulatory Factor 1, Cytotoxic Lymphocyte Maturation Factor 1, p35)|Interleukin 12A Precursor|Interleukin-12 Alpha Chain|Interleukin-12 Alpha Chain Precursor|NF Cell Stimulatory Factor Chain 1|NFSK|NKSF1|Natural Killer Cell Stimulatory Factor 1, 35 kD Subunit|Natural Killer Cell Stimulatory Factor, 35-kD Subunit|interleukin 12, p35	IL12A (p35) comprises one chain of the heterodimeric IL12. Interleukin-12 is a novel cytokine cloned from B-cell lines. It has a broad array of potent biologic activities, acting at picomolar and subpicomolar levels on both T and NK cells. It stimulates the production of interferon gamma from T-cells and natural killer cells and also induces differentiation of TH1 cells. Sequence comparisons showed that p35 is related in sequence to ligands of the cytokine receptor family, most closely to IL6 and GCSF. On the other hand, p40 is a member of the cytokine receptor family, most closely related to IL6R, and forms a subgroup with IL6R and GCSFR. (from OMIM 161560)
C28509	Interleukin-12B	Protein_Complex_Subunit	Interleukin-12B|Cytotoxic Lymphocyte Maturation Factor 2, p40|IL12B|IL23, subunit p40|Interkeukin-12 beta chain|Interleukin 12, p40|Interleukin 12B|Natural Killer Cell Stimulatory Factor-2	IL12B (p40) comprises one chain of the heterodimeric IL12. Interleukin-12 is a novel cytokine cloned from B-cell lines. It has a broad array of potent biologic activities, acting at picomolar and subpicomolar levels on both T and NK cells. It stimulates the production of interferon gamma from T-cells and natural killer cells and also induces differentiation of TH1 cells. Sequence comparisons showed that p40 is a member of the cytokine receptor family, most closely related to IL6R, and forms a subgroup with IL6R and GCSFR. On the other hand, p35 is related in sequence to ligands of the cytokine receptor family, most closely to IL6 and GCSF. (from OMIM 161560)
C28510	Fusion_Gene	Gene	Fusion Gene	A hybrid gene created by joining portions of two different genes (to produce a new protein) or by joining a gene to a different promoter (to alter or regulate gene transcription). These can be created by chromosomal aberration or by laboratory methods. (from On-line Medical Dictionary and NCI)
C28511	Nitric_Oxide_Synthetase	Oxidoreductase	Nitric Oxide Synthetase|EC 1.14.13.39|NADPH-Diaphorase|NO Synthase|Nitric Oxide Synthase|Nitric-Oxide Synthase	Expressed in various cell types, Nitric Oxide Synthases (NOS Family) are constitutive or inducible calcium/calmodulin stimulated homodimers stabilized by BH4 that bind FAD and FMN cofactors, generally contain a flavodoxin-like domain, and synthesize reactive free radical nitric oxide messenger from L-arginine. NO can act as a neurotransmitter and has antimicrobial and antitumoral activities in macrophages. IL12 requires NOS to stimulate tyrosine-phosphorylation of STAT4 by TYK2 in NK cytotoxicity. Vascular NO (endothelia) inhibits muscle contraction through a cGMP pathway, inhibits platelet aggregation, and mediates VEGF-induced angiogenesis. Endothelial AKT phosphorylates and enhances NOS activity. Potentially influencing energy balance, NO can trigger cGMP-dependent mitochondrial biogenesis mediated by induction of the master regulator PPARGC1. (NCI)
C28512	Mitochondrial_DNA	Deoxyribonucleic_Acid	Mitochondrial DNA|mtDNA	Typically small, circular, intronless, and maternally inherited, mitochondrial DNA (mtDNA) is the multicopy deoxyribonucleic acid genome of mitochondria, intracellular organelles responsible for vital respiratory chain and oxidative phosphorylation reactions in higher eukaryotes. Replicated and transcribed by a separate enzymatic machinery from that of nuclear DNA, mtDNA encodes only a subset of mitochondrial functions. (NCI04)
C28513	Heterodimerization	Dimerization	Heterodimerization	Heterodimerization involves a biophysical interaction between two dissimilar biological molecules or subunits, such as between two proteins. The interaction is often mediated by a biophysical interaction between one or more specific domains within each subunit and, typically, significantly influences the function of each subunit.
C28514	Homodimerization	Dimerization	Homodimerization	Homodimerization involves a biophysical interaction between two identical biological molecules or subunits, such as proteins. The interaction is often mediated by a biophysical interaction between one or more specific domains within the subunits and, typically, significantly influences the function of the subunits.
C28515	Glutamic_Acid_Hydrochloride	Miscellaneous_Adjuvant	Glutamic Acid Hydrochloride|Acidoride|Acidulin|Glutamic acid hydrochloride|Muriamic	The hydrochloride salt form of glutamic acid, a non-essential amino acid.  Used as a gastric acidifier, glutamic acid hydrochloride releases hydrochloric acid into the stomach, thereby lowering gastric pH. (NCI)
C28516	Sickle_Cell_Dactylitis	Palmar-Plantar_Erythodysthesia	Sickle Cell Dactylitis
C28517	Drug_Implant	Retired_Concepts	Drug Implant
C28518	Double_Stranded_RNA_Virus	RNA_Virus	Double Stranded RNA Virus|dsRNA Virus	A virus that has double stranded RNA as its genetic material.
C28519	FOXO3A_Gene	Transcription_Factor_Gene	FOXO3A Gene|FOXO3A|Forkhead Box O3A Gene	The FOXO3A Gene at 6q21 encodes Forkhead Box O3A, which belongs to the forkhead family of transcription factors characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. (From LocusLink and NCI)
C28520	Forkhead_Box-O3A_Protein	Transcription_Factor	Forkhead Box O3A|FOXO3A	Forkhead Box O3A, encoded by the FOXO3A Gene, belongs to the forkhead family of transcription factors characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. (From LocusLink and NCI)
C28521	JAW1-Related_Protein	Protein_with_Unknown_or_Unclassified_Function	JAW1-Related Protein|Inositol 1,4,5-triphosphate-associated cGMP Kinase Substrate|MRVI1	The gene encoding this protein is similar to a mouse putative tumor suppressor gene that is frequently disrupted by mouse AIDS-related virus (MRV). The protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is downregulated during myeloid differentiation. Therefore, this gene may be a myeloid leukemia tumor suppressor gene. This protein is an inositol 1,4,5-triphosphate-associated cGMP kinase substrate. Calcium release from the endoplasmic reticulum controls a number of cellular processes, including proliferation and contraction of smooth muscle and other cells and contributes to the antiproliferative and proapoptotic effects of nitric oxide and cGMP. (from LocusLink and OMIM)
C28522	Musculin	Protein_with_Unknown_or_Unclassified_Function	Musculin|Activated B-cell Factor-1|MSC|Myogenic Repressor	The predicted 218-amino acid protein contains a bHLH motif, a putative nuclear localization signal, a glycine-rich region, and a stretch of acidic residues. MSC is capable of binding an E-box element either as a homodimer or as a heterodimer with E2A in vitro, and forms heterodimers with E2A proteins in vivo. MSC contains a transcriptional repression domain and is capable of inhibiting the transactivation capability of E47, an E2A protein, in mammalian cells. MSC is a downstream target of the B-cell receptor signal transduction pathway. Mice engineered to lack the protein lack muscle structures derived from the first brachial arch. (from LocusLink and OMIM)
C28523	AHR_Gene	Transcription_Factor_Gene	AHR Gene|AHR|Ah Receptor Gene|Aryl Hydrocarbon Receptor Gene	The AHR gene at 7p15 encodes Aryl hydrocarbon receptor, which is a ligand-activated transcription factor involved in the regulation of biological responses to planar aromatic hydrocarbons. AHR has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. AHR ligands include a variety of aromatic hydrocarbons. (From LocusLink and NCI)
C28524	_7p15	Chromosome_Band	7p15	A chromosome band present on 7p
C28525	AMFR_Gene	Cytokine_Receptor_Gene	AMFR Gene|AMF Receptor Gene|AMFR|Autocrine Motility Factor Receptor Gene|GP78 Gene|RNF45 Gene	The AMFR Gene at 16q21 encodes Autocrine Mobility Factor Receptor, which is a glycosylated transmembrane protein and a specific receptor for autocrine motility factor. Autocrine Mobility Factor is a tumor motility-stimulating protein secreted by tumor cells. The receptor, which shows some sequence similarity to tumor protein p53, is localized to the leading and trailing edges of carcinoma balder cells. The level of expression in gastric cancer is associated with the pathologic stage and grade of tumor penetration. Positive AMFR expression is significantly associated with poor prognosis. Two transcript variants encoding different isoforms have been found for this gene. (From LocusLink, OMIM and NCI)
C28526	Macrophage_Stimulating-1_Receptor	Receptor_Tyrosine_Kinase	Macrophage Stimulating 1 Receptor|MSP Receptor|MST1R|Macrophage Stimulating Protein Receptor|c-Met-related Tyrosine Kinase	A member of the MET receptor family. The protein is membrane-spanning disulfide-linked heterodimer with intracellular tyrosine kinase activity.  It is synthesized as a single polypeptide which is processed to the 185-kD heterodimer of 35-kD (alpha) and 150-kD (beta) subunits joined by the predicted disulfide linkage. The protein is a specific cell surface receptor for macrophage stimulating protein. Targeted expression in mice results in frequent, multiple lung tumors. It may also play a role in progression of some colorectal cancers (from OMIM, Oncogene 2002;21:6382-6 and Oncogene 2003;22:186-97)
C28527	_16q21	Chromosome_Band	16q21	A chromosome band present on 16q
C28528	Muscle-Specific_Kinase	Receptor_Tyrosine_Kinase	Muscle-Specific Kinase|MUSK|Muscle, Skeletal, Receptor Tyrosine Kinase|Receptor Tyrosine Kinase MuSK	Called MuSK for muscle-specific kinase. It is a receptor-like tyrosine kinase restricted to skeletal muscle in its expression. Mice lacking MuSK show a defect in initiation of postsynaptic differentiation. (from OMIM)
C28529	ITGAX_Gene	Cell_Adhesion_Molecule_Gene	ITGAX Gene|CD11c|ITGAX|Integrin, Alpha X (Antigen CD11C (p150), Alpha Polypeptide) Gene	Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. ITGB2 encodes the integrin beta 2 chain. Mutations in the beta-2 subunit of the leukocyte cell adhesion molecule have been found to cause the autosomal recessive disorder of neutrophil function known as leukocyte adhesion deficiency(from LocusLink)
C28530	CDK5_Gene	Cyclin-Dependent_Kinase_Gene	CDK5 Gene|CDK5|Cell Division Kinase 5 Gene|Cyclin-Dependent Kinase 5 Gene|PSSALRE	The CDK5 Gene encodes Cyclin-Dependent Kinase 5 (CDK5), which is a dimeric serine/threonine protein kinase. CDK5 contains a catalytic and a regulatory subunit and is involved in cell cycle control. Expressed predominantly in neurons, CDK5 belongs to the CDC2/CDKX subfamily, interacts with D1- and D3-type G1 cyclins, and phosphorylates histone H1, TAU, MAP2, NF-H, and NF-M. (from SWISS-PROT Q00535, OMIM 123831, and NCI)
C28531	AZU1_Gene	Immunoprotein_Gene	AZU1 Gene|AZAMP Gene|AZU|AZU1|Azurocidin 1 (Cationic Antimicrobial Protein 37) Gene|Azurocidin 1 Gene|CAP37 Gene|Cationic Antimicrobial Protein 37 Gene|Cationic Antimicrobial Protein-37 Gene|HBP Gene|Heparin-Binding Protein Gene|Humazur Gene|NAZC Gene|Neutrophil Azurocidin Gene	The AZU1 Gene at 19p13.3 encodes Azurocidin, an antibiotic protein of azurophil granules (specialized lysosomes of the neutrophil) with monocyte chemotactic and antibacterial activity. It is also an important multifunctional inflammatory mediator. This gene is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at the tip of the short arm of chromosome 19. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. (From LocusLink, OMIM and NCI)
C28532	CEBPE_Gene	Transcription_Factor_Gene	CEBPE Gene|C/EBP-Epsilon|CCAAT/Enhancer Binding Protein (C/EBP), Epsilon Gene|CEBPE|CRP1	The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-delta. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with Specific Granule Deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.(LocusLink)
C28533	Transport_Protein_Gene	Ligand_Binding_Protein_Gene	Transport Protein Gene	Transport Protein Genes encode a diverse group of proteins that function as carriers of ligands through solubility barriers such as aqueous body fluids or in active transport across cell membranes. (NCI)
C28534	BDNF_Gene	Growth_Factor_Gene	BDNF Gene|BDNF|Brain-Derived Neurotrophic Factor Gene|MGC34632	The BDNF gene encodes Brain-Derived Neurotrophic Factor, a member of the nerve growth factor family. It exerts trophic action on retinal, cholinergic, and dopaminergic neurons in the brain and on motor and sensory neurons in the peripheral nervous system. Target cells regulate neuronal survival by producing neurotrophic factors, such as NGF and BDNF, which show sequence similarity. Proforms of NGF and BDNF are secreted and cleaved by plasmin serine protease and matrix metalloproteinases (MMP7, MMP3); proforms preferentially activate p75(NTR) to mediate apoptosis and mature forms activate TRK receptors to promote survival. Huntingtin up regulates transcription of BDNF. Mutated Huntingtin decreases production of BDNF leading to neuronal death. (from OMIM and NCI)
C28536	_12p13_1-p12	Chromosome_Band	12p13.1-p12	A chromosome band present on 12p
C28537	APP_Gene	Receptor_Gene	APP Gene|A4|AAA|ABETA|AD1|APP|Amyloid Beta (A4) Precursor Protein (Protease Nexin-II, Alzheimer Disease) Gene|CVAP	The 290-kb 19-exon human APP Gene (APP Family) at 21q21.3 encodes Amyloid Beta A4 Protein, an N-/O-glycosylated sulfated metal ion-binding type I cell surface protein containing a BPTI protease inhibitor domain. Widely expressed APP is processed by secretases into soluble peptides, membrane-anchored fragments, plaque amyloid components, and cytotoxic fragments. Phosphorylation by Casein Kinases, CDC5, CDC2, and MAPK10 can affect processing, interaction with Fe65, and SHC binding. A kinesin I membrane receptor for cell mobility, adhesion, and axonogenesis, APP variants inhibit Notch signaling, regulate copper homeostasis, bind lipoproteins, activate transcription, and enhance apoptosis via G(O) and JIP pathways. NPXY is required for binding protein PID domains, endocytosis, and BaSS sorting. APP defects cause Alzheimer's disease and cerebroarterial amyloidosis. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28538	_21q21_3	Chromosome_Band	21q21.3	A chromosome band present on 21q
C28539	AR_Gene	Nuclear_Receptor_Gene	AR Gene|AIS|AR|Androgen Receptor (Dihydrotestosterone Receptor; Testicular Feminization; Spinal and Bulbar Muscular Atrophy; Kennedy Disease) Gene|DHTR|HUMARA|KD|NR3C4|SBMA|SMAX1|TFM	The 180-kb human AR Gene (NR3 Family) at Xq11.2-q12 encodes the Androgen Receptor transcription factor that regulates gene expression, cell proliferation, and differentiation. AR has 3 domains: N-terminal modulating (exon 1), DNA-binding (two C4 Zinc fingers, exons 2-3), and C-terminal hormone-binding (5 remaining exons). Polymorphic N-terminal poly-Gln tracts bind RAN, enhancing transactivation; decreased with increased poly-Gln length. An 87-kD (AR-A) isoform lacks a normal N-terminus, seen in the 110 kD (AR-B) form; A and B may differ in function. Ligand bound receptor translocates to the nucleus, homodimerizes, binds DNA, and stimulates transcription. Polyglutamine expansion causes Kennedy's disease. Other mutations are associated with androgen insensibility syndrome. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28540	Xq11_2-q12	Chromosome_Band	Xq11.2-q12	A chromosome band present on Xq
C28541	PLG_Gene	Regulatory_Gene	PLG Gene|PLG|Plasminogen Gene	The PLG gene at 6q26 encodes Plasminogen, the zymogen in the circulating blood from which the active form, plasmin, is formed. Plasmin is a proteolytic enzyme with a specificity similar to that of trypsin, belonging to the family of serine proteinases. The main function of plasmin is the digestion of fibrin in blood clots. Angiostatin, an angiogenesis inhibitor that mediates the suppression of tumor metastases, is an internal proteolytic fragment of plasminogen containing at least 3 of the kringles of plasminogen. (From LocusLink and NCI)
C28542	BTC_Gene	Growth_Factor_Gene	BTC Gene|BTC|Betacellulin Gene	The 50-kb human BTC Gene (EGF Family) at 4q13-q21 encodes 178-aa 19.7-kD (precursor) Betacellulin, a potent growth factor ligand for the EGF (and related) receptor(s) containing an EGF-like domain and synthesized in several tissues primarily as a type I transmembrane precursor protein that is proteolytically processed to an extracellular mature form. (NCI)
C28543	TFAP2B_Gene	Transcription_Coactivator_Gene	TFAP2B Gene|AP-2 Beta|AP-2B|AP2-B|AP2-Beta|CHAR|TFAP2B|Transcription Factor AP-2 Beta (Activating Enhancer Binding Protein 2 Beta) Gene	Similar in structure toTFAP2A, 25-kb human TFAP2B Gene (AP-2 Family) at 6p21-p12 encodes 449-aa 49-kD AP-2 Beta, a sequence-specific dimeric transcription co-activator that binds to 5prime-GCCNNNGGC-3prime DNA sequence in cellular enhancers of many genes involved in retinoic acid-induced neuroectodermal differentiation. AP-2 Beta also suppresses expression of the C/EBP-Alpha, MCAM/MUC18, and c-MYC genes. Unlike the N-terminal activation domain, the DNA-binding and dimerization domains of AP-2-Beta are highly conserved with other family members. AP2-B can form homodimers or heterodimers with AP-2 family members. TFAP2B defects cause of Char syndrome. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28544	_6p21-p12	Chromosome_Band	6p21-p12	A chromosome band present on 6p
C28546	Alkyl-Guanine_Transferase_Inhibitor	Enzyme_Inhibitor	Alkyl-Guanine Transferase Inhibitor	A substance that inhibits Alkyl-Guanine Transferase, an enzyme involved with DNA repair.(NCI)
C28547	Chromosome_Segregation	Cell_Division_Process	Chromosome Segregation	The separation of chromosomes into daughter cells during cell division. (GO)
C28548	J5_Antiserum	Antiserum	Monoclonal J5|Antiserum to Endotoxin Core	An antiserum comprised of a J5 mutant of E. coli that targets the lipid A component of endotoxin of gram-negative bacteria. (NCI)
C28549	Synchrovax_SEM_Plasmid_DNA_Vaccine	DNA_Vaccine	Synchrovax SEM Plasmid DNA Vaccine|Synchrotope MA2M Plasmid DNA Vaccine	A vaccine comprised of recombinant plasmid DNA encoding Synchrovax SEM, a proprietary vaccine design employing multiple peptides, to manipulate cytotoxic T lymphocytes. (NCI)
C28550	Recombinant_Adenovirus-hIFN-beta	Viral_Vector-Gene_Complex	Recombinant Adenovirus-hIFN-beta|Ad-hIFN-beta|BG00001	A recombinant replication-defective adenovirus which encodes the gene for the cytokine human interferon-beta (IFN-beta). Once inserted into and replicating in host tumor cells, recombinant adenovirus-hIFN-beta expresses human IFN-beta, which may stimulate an antiproliferative natural killer (NK) cell response against tumor cells and induce caspase-mediated tumor cell apoptosis. (NCI04)
C28551	Globo-H-GM2-Lewis-y-MUC1-32_aa_sTn_c_TF_c_Tn_c_KLH_Conjugate_Vaccine	Antineoplastic_Vaccine	Globo-H-GM2-Lewis-y-MUC1-32(aa)-sTn(c)-TF(c)-Tn(c)-KLH Conjugate Vaccine	A heptavalent vaccine consisting of the tumor-associated carbohydrate antigens globohexaosylceramide (globo-H), GM2, Lewis-y, MUC1-32(aa), sTn(c), TF(c), and Tn(c) conjugated with keyhole limpet hemocyanin (KLH), an immunomodulator.  This vaccine may induce the production of IgG and IgM antibodies and an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumors expressing these antigens. (NCI04)
C28552	Globo-H-GM2-Lewis-y-MUC1-32_aa_sTn_c_TF_c_Tn_c_KLH-Conjugate-Vaccine_QS21	Chemotherapy_Regimen	Globo-H-GM2-Lewis-y-MUC1-32(aa)-sTn(c)-TF(c)-Tn(c)-KLH Conjugate Vaccine/QS21	A heptavalent vaccine comprised of Globo-H (Globo H Hexasaccharide 1), GM2, Lewis-y, MUC1-32(aa), sTn(c), TF(c), and Tn(c) antigens conjugated with Keyhole Limpet Hemocyanin, an immunomodulator, plus QS21, an immune enhancer. (NCI)
C28553	Aryl_Hydrocarbon_Receptor_Nuclear_Translocator	Protein_Complex_Subunit	Aryl Hydrocarbon Receptor Nuclear Translocator|ARNT|ARNT Protein|Dioxin Receptor, Nuclear Translocator|HIF-1 Beta|HIF-1Beta|HIF1-BETA|HIF1B|HIF1BETA|Hypoxia-Inducible Factor 1 Beta|Hypoxia-Inducible Factor 1, Beta Subunit	Aryl Hydrocarbon Receptor Nuclear Translocator, encoded by the ARNT gene, heterodimers with HIF1A or EPAS1/HIF2A and functions as a transcriptional regulator of the adaptive response to hypoxia. Efficient DNA binding requires dimerization with another bHLH protein. This nuclear protein is also required for activity of the Ah (dioxin) receptor and for the ligand-binding subunit to translocate from the cytosol to the nucleus after ligand binding. The complex then initiates transcription of genes involved in the activation of PAH procarcinogens. (From Swiss-Prot and LocusLink)
C28554	Death	Finding	Death	The absence of life or state of being dead.
C28555	_9q22_31	Chromosome_Band	9q22.31	A chromosome band present on 9q
C28556	MAX_Interacting_Protein-1	Transcription_Repressor_Corepressor	MAX Interacting Protein 1|MAD|MAD Protein|MAD Protein (MAX-Binding Protein)|MAX Dimerization Protein|MAX Dimerization Protein 2|MAX Dimerizer|MAX-Interacting Protein 1|MXD1|MXI1	Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. MAX Interacting Protein 1, encoded by the MXI1 gene, is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Two transcript variants encoding different isoforms have been identified for the MXI1 gene. (from LocusLink and NCI)
C28557	M-Phase_Promoting_Factor	Protein_or_Riboprotein_Complex	M-Phase Promoting Factor|MPF|Mitosis-Promoting Factor	M Phase-Promoting Factor is a protein kinase complex that drives both the mitotic and meiotic cycles in all eukaryotic organisms. In meiosis it induces immature oocytes to undergo meiotic maturation. In mitosis it has a role in the G2/M phase transition. Once activated by CYCLINS; MPF directly phosphorylates some of the proteins involved in nuclear envelope breakdown, chromosome condensation, spindle assembly, and the degradation of cyclins. The catalytic subunit of MPF is PROTEIN P34CDC2. (From http://www.online-medical-dictionary.org/medical-dictionary-m/M-Phase-Promoting-Factor.htm)
C28558	Neurotrophic_Tyrosine_Kinase_Receptor_Type-1	Receptor_Tyrosine_Kinase	Neurotrophic Tyrosine Kinase Receptor Type 1|NTRK1|Nerve Growth Factor Receptor Type 1	Human NTRK1 Gene (TKRI/INSR Family) encodes neuronal TRKA-I and non-neural TRKA-II isoforms (similar biological properties) of type I membrane protein Neurotrophic Tyrosine Kinase Receptor Type 1, containing 2 LRR repeats and 2 Ig-like C2-type domains. NTRK1 exists in dynamic equilibrium as low affinity monomers and high affinity dimers with TRKA, TRKB, or TRKC to bind NGF, NTF3, NTF4/5, and BDNF neurotrophins that regulate development and function of the nociceptive and thermoregulatory nervous systems. Ligand stimulation of TRK activates autophosphorylation, SHC, PI-3 kinase, PLC-gamma-1, and ERK1 signaling pathways. NTRK1 defects cause CIPA. Chromosomal rearrangements of NTRK1 fused to TPM3 or to TFG in t(1;3)(q21;q11) are associated with papillary thyroid carcinoma. (NCI)
C28559	CDC2_Gene	Cyclin-Dependent_Kinase_Gene	CDC2 Gene|CDC2|CDK1 Gene|Cell Cycle Controller CDC2 Gene|Cell Division Control Protein 2 Homolog Gene|Cell Division Cycle 2 Protein Gene|Cell Division Cycle 2, G1 to S and G2 to M Gene|Cyclin-Dependent Kinase 1 Gene|p34 Protein Kinase Gene|p34(CDC2) Gene	The CDC2 Gene at 10q21.1 encodes Cyclin-Dependent Kinase 1, which is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. (From LocusLink)
C28560	Xq22_2	Chromosome_Band	Xq22.2	A chromosome band present on Xq
C28561	Nerve_Growth_Factor_Receptor_Associated_Protein-1	Signaling_Protein	Nerve Growth Factor Receptor Associated Protein 1|NADE|NGFRAP1|Nerve Growth Factor Receptor-Associated Cell Death Executor|Ovarian Granulosa Cell Protein (13kD)|p75(NTR)-Associated Cell Death Executor	Cloned by its ability to interact with the death domain of nerve growth factor receptor. Likely to be involved in nerve growth factor-mediated apoptosis. (from OMIM)
C28562	_14q13_2	Chromosome_Band	14q13.2	A chromosome band present on 14q
C28563	G2-M_Transition	Cell_Division_Process	G2/M Transition	Progression from G2 phase to M phase of the standard mitotic cell cycle. (From Gene Ontology)
C28564	Neuromedin-B_Receptor	G_Protein-Coupled_Receptor	Neuromedin B Receptor|NMBR	A mammalian homolog of amphibian bombesin, Neuromedin B receptor binds neuromedin B, a potent mitogen and growth factor for normal and neoplastic lung and for gastrointestinal epithelial tissue. (from OMIM)
C28565	NMYC_Interactor	Ligand_Binding_Protein	NMYC Interactor|NMI|NMYC and STAT Interactor	NMYC interactor (NMI) is a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. (LocusLink)
C28566	Protein_Fragment	Gene_Product	Protein Fragment	A fragment of a protein, which may be a diagnostic or prognostic factor and used as a biomarker. (NCI)
C28567	CTLA4_Gene	Receptor_Gene	CTLA4 Gene|CD152 Antigen Gene|CD152 Gene|CTLA-4 Gene|CTLA4|Cytotoxic T-Lymphocyte Protein 4 Gene|Cytotoxic T-Lymphocyte-Associated Antigen 4 Gene|Cytotoxic T-Lymphocyte-Associated Protein 4 Gene|Cytotoxic T-Lymphocyte-Associated Serine Esterase-4 Gene	The CTLA4 gene at 2q33 encodes Cytotoxic T-Lymphocyte-Associated Protein 4, which is a Type I membrane protein, containing 1 immunoglobulin-like V-type domain and possibly involved in T-cell activation. This protein binds to B7-1 (CD80) and B7-2 (CD86), and is widely expressed with highest levels in lymphoid tissues. The variant Ala-17 is associated with an increased risk for autoimmune disorders as Graves disease (GRD), type I insulin-dependent diabetes mellitus (IDDM12), and thyroid-associated orbitopathy (TAO). The variant Thr-17 is associated with predisposition to celiac disease, a gluten sensitive enteropathy characterized by small bowel mucosal atrophy. (From LocusLink, Swiss-Prot and NCI)
C28568	_2q34	Chromosome_Band	2q34	A chromosome band present on 2q
C28569	MYB_Gene	Transcription_Factor_Gene	MYB Gene|MYB|V-Myb Myeloblastosis Viral Oncogene Homolog|c-MYB|v-MYB Myeloblastosis Viral Oncogene Homolog (Avian) Gene	Human v-myb myeloblastosis viral oncogene homolog (avian) (MYB) gene, a proto-oncogene located at 6q22, encodes the MYB proto-oncogene protein. MYB produces 6 isoforms of this protein via alternative splicing.
C28570	CBFA2T1_Gene	Transcription_Factor_Gene	RUNX1T1 Gene|AML1T1|CBFA2T1|CBFA2T1 Gene|CDR|ETO|MGC2796|MTG8|Myeloid Translocation Gene on 8q22|RUNX1T1|Runt-Related Transcription Factor 1; Translocated to, 1 (Cyclin D-Related) Gene|ZMYND2	Centromerically transcribed near MTGR1 and MTGR2, 13-exon human CBFA2T1 Gene at 8q22 expresses variant isoforms of conserved 604-aa 67.6-kD ETO Protein, a putative MYND zinc finger transcription factor in brain, heart, lung, pituitary, skeletal muscle, pancreas, placenta, testis, and ovary. With alternate 5-prime exon, variant 2 MTG8B has a distinct N-terminus. With alternate 5-prime exon and downstream translation, variants 3 and 4 encode MTG8C with a short N-terminus. One frameshifted MTG8 variant lacks C-terminal zinc fingers, a P/S/T-rich domain, and a coiled-coil structure. In AML-M2, t(8;21)(q22;q22) in stem cells produces a fused RUNX1-CBFA2T1 gene; the chimeric protein, associated with NCOR/HDAC, may repress transcription and differentiation in hematopoietic precursors. p14(ARF) may be a target of AML1-ETO. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28571	NR3C1_Gene	Nuclear_Receptor_Gene	NR3C1 Gene|GCR|GR|GRL|NR3C1|Nuclear Receptor Subfamily 3, Group C, Member 1 (Glucocorticoid Receptor) Gene	Widely expressed human NR3C1 Gene (NR3 Family) encodes 6 isoforms of phosphorylated cytoplasmic (inactive)/hyperphosphorylated nuclear (active) Glucocorticoid Receptor, containing a (N) modulating domain, a DNA-binding domain, and a (C) steroid-binding domain. Alpha-A (777-aa, 86-kDa precursor) predominates. Complexed with HSP90, HSP70, and FKBP5 or PPP5C, activate GR is transported (by dynein/FKBP4) to the nucleus and binds to target GREs as a homodimeric or heterodimeric (NR3C2/RXR) transcription factor and modulates other transcription factors to regulate blood glucose concentration, protein/fat metabolism, inflammatory responses, cell proliferation, and differentiation. GR appears to interact with NRIP1, POU2F1, POU2F2, STAT5A, STAT5B, SMARCA4, CREBBP/EP300, TADA2L, p160, NCOA2, and NCOA6. Sumoylation and BAG1 interaction inhibits transactivation. GR defects cause glucocorticoid resistance. (NCI)
C28572	SLC2A1_Gene	Transport_Protein_Gene	SLC2A1 Gene|GLUT|GLUT1|GTR1|Glucose Transporter Type 1 Gene|SLC2A1|Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 1 Gene	Expressed at variable levels in many tissues but at high levels in erythrocytes and brain endothelia, human SLC2A1 Gene (Glucose Transporter Family) at 1p35-p31.3 encodes 492-aa 54-kDa integral membrane glycoprotein Glucose Transporter Type 1 Erythrocyte/Brain, a major facilitative glucose transporter in the blood-brain barrier likely responsible for constitutive or basal glucose uptake/transport. With broad substrate specificity, SLC2A1 can transport a wide range of aldoses including pentoses and hexoses. SLC2A1 defects cause GLUT1 deficiency syndrome, a defect in glucose transport across the blood-brain barrier. (NCI)
C28573	ENG_Gene	Growth_Factor_Receptor_Gene	ENG Gene|CD105|CD105 Gene|END|END Gene|ENG|Endoglin (Osler-Rendu-Weber Syndrome 1) Gene|Endoglin Gene|HHT1|HHT1 Gene|ORW|ORW Gene|ORW1|ORW1 Gene	The ENG gene at 9q33-q34.1 encodes Endoglin, which is a homodimeric transmembrane glycoprotein highly expressed by endothelial cells. Endoglin may play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin homodimer forms an heteromeric complex with the signaling receptors for Transforming Growth Factor-Beta: TGF-Beta Receptors I and/or II. It is able to bind TGF-Beta 1, and 3 efficiently and TGF-Beta 2 less efficiently. Mutations in the ENG gene produce hereditary hemorrhagic telangiectasia. (From LocusLink, Swiss-Prot and NCI)
C28574	FN1_Gene	Extracellular_Matrix_Protein_Gene	FN1 Gene|CIG|FINC|FN|Fibronectin 1 Gene|LETS	The 75-kb single copy human FN1 Gene at 2q34 may encode alternative isoforms of 2386-aa 262.6-kD Fibronectin precursor, a sulfated disulfide bound glycoprotein with multiple type I, II, and III fibronectin domains. MSF FN70 is an isoform. Plasma (hepatocytes) and cellular (fibroblasts and epithelia) FN differ in activity. Cell surface cellular FN (di/multimeric) is deposited in the ECM. FN is involved in embryogenesis, cell adhesion, migration, and motility, opsonization, wound healing, coagulation, host defense, cell shape, and metastasis. It stimulates endocytosis and may promote clearance of C1q-coated immune complexes. FN binds cell surface integrin, C1q, collagen, fibrin, hyaluronic acid, heparin, FBLN1, and actin. Most cells depend on FN to bind collagen. Talin-1 may link FN/Integrin with the actin cytoskeleton. FN may promote contact inhibition. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28575	GATA1_Gene	Transcription_Factor_Gene	GATA1 Gene|ERYF1|GATA Binding Protein 1 (Globin Transcription Factor 1) Gene|GATA1|GF1|NFE1	The 7.8-kb human GATA1 Gene (GATA Family) at Xp11.23 encodes 413-aa 42.8-kD tissue-specific transcriptional activator GATA-1, a general switch factor for erythroid/megakaryocyte development, containing a conserved central domain of 2 GATA/C4 zinc fingers that recognize the WGATAR motif. The fingers cooperate in specific binding of the consensus DNA sequence (A/T)GATA(A/G) in erythroid genes. The N-finger interacts with zinc finger FOG1 protein, also essential for erythroid/megakaryocyte development. V205M abrogates GATA1 N-finger interaction with FOG. Regulatory feedback by death-receptor ligands results in caspase-mediated GATA1 degradation and impaired erythroblast development. Arg216gly substitution in the GATA1 N-finger causes X-linked thrombocytopenia; reduces GATA1/FOG1 affinity for palindromic GATA sites. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28576	_6p24_1	Chromosome_Band	6p24.1	A chromosome band present on 6p
C28577	EDN1_Gene	Peptide_Hormone_Gene	EDN1 Gene|ET1|Endothelin 1 Gene	The EDN1 gene at 6p24.1 encodes Endothelin-1, which is a potent, 21-amino acid vasoconstrictor peptide produced by vascular endothelial cells. Endothelin-1 inhibits active Na-K transport by inhibiting Na(+)-K(+)-ATPase in intact renaltubular epithelial cells. (From OMIM, PubMed and NCI)
C28578	Harvey_Murine_Sarcoma_Virus	Gammaretrovirus	Harvey Murine Sarcoma Virus
C28579	Ethylchlorformate_Vaccine	Antineoplastic_Vaccine	Ethylchlorformate Vaccine	A tumor vaccine comprised of ethylchlorformate polymerized tumor protein, obtained by treating tumor cells with ethylchloroformate to produce a tumor-specific immunotherapeutic agent. (NCI)
C28580	CpG_7909	Phosphorothioate_Oligonucleotide	CpG 7909	A synthetic 24-mer oligonucleotide containing 3 CpG motifs with potential antineoplastic and immunostimulatory activity. CpG 7909 selectively targets Toll-like receptor 9 (TLR9), thereby activating dendritic and B cells and stimulating cytotoxic T cell and antibody responses against tumor cells bearing tumor antigens. (NCI05)
C28581	psiCRIP-MFG-S-TK1-67	Viral_Vector-Gene_Complex	psiCRIP-MFG-S-TK1-67	A gene transfer agent comprised of murine packaging cell lines, psiCRIP, and an engineered retroviral vector MFG-S containing the coding region of amino acid residues from 1-67 of HSV Thymidine Kinase which allows gene transfer to occur without viral replication in transduced cells and has been used as a selection marker with ganciclovir treatment.(NCI)
C28582	H2AX_Gene	Structural_Gene	H2AFX Gene|H2A Histone Family, Member X Gene|H2A.X|H2A/X|H2AFX|H2AX	Human H2AX Gene (H2A Family) at 11q23.2-q23.3 produces an alternatively processed 0.6-kb stem loop transcript or a 1.6-kb read through transcript, that generate 142-aa basal Histone H2AX having a unique conserved C-terminal sequence, QASQEY. Expressed in G1 and S-phase, H2AX synthesis is not replication linked. An upstream CCAAT box shares binding factors with Histone H2AZ. Downstream H2AX overlaps HMBS. NBS1/phospho-H2AX (gamma-H2AX) associate with irradiation-induced and V(D)J-induced DNA double-strand breaks. In pre-thymocytes, NBS1/gamma-H2AX form at RAG1-mediated TCRA V(D)J cleavage sites. NBS1/gamma-H2AX facilitate AID-dependent DNA break repair in G1 cells undergoing Ig heavy-chain constant region class switch recombination. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28583	_11q23_2-q23_3	Chromosome_Band	11q23.2-q23.3	A chromosome band present on 11q
C28584	_7p14-p12	Chromosome_Band	7p14-p12	A chromosome band present on 7p
C28585	HLA-A_Gene	Immunoprotein_Gene|MHC_Class-I_Gene	HLA-A Gene|HLA-A|HLAA|Major Histocompatibility Complex, Class I, A Gene	Within the 2-Mb Class I region of the 4-Mb HLA complex, 122-kb human HLA-A (A2 allele) Gene (HLA Family) at 6p21.3 encodes HLA-A(2) Antigen, a 365-aa 41-kD membrane-anchored class I alpha heavy chain glycoprotein heterodimerized with 11.6-kD beta-2 microglobulin. HLA structure reflects protein organization: exon 1 (signal peptide), exons 2-3 (alpha1, 2 domains), exon 4 (alpha3 domain), exon 5 (transmembrane region), exons 6-8 (cytoplasmic tail). Hundreds of HLA-A alleles have been described. Polymorphic alpha1/2 determine peptide binding specificity. Ig-like alpha3 mediates CD8 binding on cytotoxic T-lymphocytes. In the immune response, HLA antigens mediate antigen presentation to TCR. HLA-A2 subtypes are associated with decreased risk of HIV-1 infection and increased frequency of early-onset Alzheimer disease.  (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28586	Transcription_Elongation	Transcription_Process	Transcription Elongation	The RNA polymerase moves along the DNA template, adding nucleotides to the growing RNA chain in accordance with the sequence of the template or coding strand. (From http://www.blc.arizona.edu/marty/411/Modules/RNAelong.html)
C28587	ID2_Gene	Transcription_Coregulator_Gene	ID2 Gene|ID2|Inhibitor of DNA Binding 2, Dominant Negative Helix-Loop-Helix Protein Gene|MGC26389	Highly expressed in most fetal tissues, the 15-kD human ID2 Gene (bHLH/ID Family) at 2p25 encodes 134-aa nuclear ID2 Protein, an HLH protein lacking a basic DNA-binding domain that heterodimerizes through the HLH domain with, and inhibits DNA binding of, other bHLH transcription factors in a dominant-negative manner by suppressing their heterodimerization with functional partners. ID proteins promote cell proliferation and likely influence of cell differentiation. ID2 inhibits antiproliferative effects of active, hypophosphorylated RB, p107, and p130 tumor suppressor proteins, allowing cell cycle progression. By inactivating RB, ID2 also abolishes p16 growth inhibitory protein function. During normal cell cycle, RB inhibits ID2 action on its targets. MYC activates ID2 transcription. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28588	IGFBP1_Gene	Transport_Protein_Gene	IGFBP1 Gene|IBP1|IGF-BP25|IGFBP1|Insulin-Like Growth Factor Binding Protein 1 Gene	Expressed in liver, endometrium, and decidua, 4-exon 6-kb human IGFBP1 Gene at 7p14-p12 encodes low molecular weight secreted 259-aa 29-kD Insulin-Like Growth Factor-Binding Protein 1 precursor containing an IGFBP domain and a thyroglobulin type-I domain. Hypoxia appears to upregulate IGFBP1 expression. IGFBP1 binds equally to plasma IGF I and IGF II with high affinity. The protein has 15 N- and C-terminal cysteines and a C-terminal RGD sequence that may promote potentiation of IGF I biologic actions. IGFBP1 is probably phosphorylated by casein kinase II, which alters IGF affinity. IGF-binding proteins prolong the half-life of IGFs and alter IGF interactions with cell surface receptors. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28589	IGFBP2_Gene	Transport_Protein_Gene	IGFBP2 Gene|BP2|IBP2|IGFBP2|Insulin-Like Growth Factor Binding Protein 2, 36kDa Gene	Separated from IGFBP5 (opposite orientation) by 20-40-kb, 4-exon 31-kb human IGFBP2 Gene at 2q33-q34 encodes cysteine-rich high molecular weight secreted 328-aa 35-kD Insulin-Like Growth Factor-Binding Protein 2 precursor, containing an IGFBP domain and a thyroglobulin type-I domain. IGF-binding proteins prolong plasma IGF half-life and alter IGF interaction with cell surface receptors. The predominant form in plasma (150-kD) contains IGF-BP53 with apparent molecular mass of 53-kD. IGFBP2 binds IGF-II with high affinity more than IGF-I. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28590	_6q14_3	Chromosome_Band	6q14.3	A chromosome band present on 6q
C28591	_4q31	Chromosome_Band	4q31	A chromosome band present on 4q
C28592	IL1A_Gene	Interleukin_Gene	IL1A Gene|Hematopoietin-1 Gene|IL-1A Gene|IL1 Gene|IL1-Alpha Gene|IL1A|IL1F1 Gene|Interleukin 1, Alpha Gene|Interleukin 1-Alpha Gene|Interleukin-1-Alpha Gene|Preinterleukin 1 Alpha Gene	The IL1A gene at 2q14 encodes Interleukin-1-Alpha, which is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. (From LocusLink)
C28593	IL1B_Gene	Interleukin_Gene	IL1B Gene|Catabolin Gene|IL-1 Gene|IL1-Beta Gene|IL1B|IL1F2 Gene|Interleukin 1 Gene|Interleukin 1, Beta Gene|Interleukin 1, Beta Proprotein Gene|Interleukin 1-Beta Gene|Interleukin-1-Beta Gene|Preinterleukin 1 Beta Gene	The IL1B gene at 2q14 encodes Interleukin-1-Beta, which is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. (From LocusLink)
C28594	Cell_Maturation	Cell_Growth_Process	Cell Maturation	Processes that create, promote, and maintain a differentiated cellular phenotype. (NCI)
C28595	IL3_Gene	Interleukin_Gene	IL3 Gene|Hematopoietic Growth Factor Gene|IL-3 Gene|IL3|Interleukin 3 (Colony-Stimulating Factor, Multiple) Gene|Interleukin 3 Gene|Interleukin 3 Precursor Gene|Interleukin-3 Gene|MCGF Gene|MULTI-CSF Gene|Mast-Cell Growth Factor Gene|Multilineage-Colony-Stimulating Factor Gene|Multipotential Colony-Stimulating Factor Gene|P-Cell Stimulating Factor Gene	The IL3 Gene at 5q31.1 encodes Interleukin-3, which is a potent growth promoting cytokine. This cytokine is capable of supporting the proliferation of a broad range of hematopoietic cell types. It is involved in a variety of cell activities such as cell growth, differentiation and apoptosis. This cytokine has been shown to also possess neurotrophic activity, and it may be associated with neurologic disorders. (From LocusLink)
C28596	IL4_Gene	Interleukin_Gene	IL4 Gene|B-Cell Stimulatory Factor 1 Gene|BSF-1 Gene|BSF1 Gene|IL-4 Gene|IL4|Interleukin 4 Gene|Interleukin-4 Gene|Interleukin-4 Precursor Gene	The IL4 Gene at 5q31.1 encodes Interleukin-4, which is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. (From LocusLink)
C28597	Kinase	Phosphotransferase	Kinase	Encoded by Kinase Family Genes, Kinase enzymes covalently transfer the terminal, gamma phosphate group from ATP to a variety of substrates and typically play key regulatory roles in diverse cellular functions. (NCI)
C28598	IL7_Gene	Interleukin_Gene	IL7 Gene|IL-7 Gene|IL7|Interleukin 7 Gene|Interleukin 7 Precursor Gene|Interleukin-7 Gene	The IL7 Gene at 8q12-q13 encodes Interleukin-7, which is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggest that this cytokine plays an essential role in lymphoid cell survival. (From LocusLink)
C28599	IL9_Gene	Interleukin_Gene	IL9 Gene|HP40 Gene|Homolog of Mouse T Cell and Mast Cell Growth Factor 40 Gene|IL-9 Gene|IL9|Interleukin 9 Gene|Interleukin 9 Precursor Gene|P40 Cytokine Gene|P40 Gene|P40 Protein Gene|P40 T-Cell and Mast Cell Growth Factor Gene|T-Cell Growth Factor P40 Gene|T-Cell/Mast Cell Growth Factor P40 Gene	Expressed by T-cells and macrophages, human IL9 Gene (IL-7/IL-9 Family) encodes 144-aa 16-kDa (precursor) secreted glycoprotein cytokine Interleukin-9, a growth factor that acts through the IL9R, which activates different STAT proteins connected to various biological processes. A hematopoietic regulator that stimulates cell proliferation and prevents apoptosis, IL9 enhances IL-2 independent and IL-4 independent growth of helper T-cells and growth of mast cells. (NCI)
C28600	IL10_Gene	Interleukin_Gene	IL10 Gene|CSIF Gene|Cytokine Synthesis Inhibitory Factor Gene|IL-10 Gene|IL10|IL10A Gene|Interleukin 10 Gene|Interleukin 10 Precursor Gene|Interleukin-10 Gene|TGIF Gene	The IL10 Gene at encodes Interleukin-10, which is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggest the function of this cytokine as an essential immunoregulator in the intestinal tract. (From LocusLink)
C28601	IL11_Gene	Interleukin_Gene	IL11 Gene|AGIF Gene|Adipogenesis Inhibitory Factor Gene|IL-11 Gene|Interleukin 11 Gene|Interleukin 11 Precursor Gene|Interleukin-11 Gene|Oprelvekin Gene	The IL11 Gene at 19q13.3-q13.4 encodes Interleukin-11, which is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. (From LocusLink)
C28602	IL14_Gene	Interleukin_Gene	IL14 Gene|HMW-BCGF Gene|High Molecular Weight B-Cell Growth Factor Gene|IL-14 Gene|IL14|Interleukin 14 Gene	The IL14 gene at 5q31 encodes Interleukin-14, which is a cytokine that induces B-cell proliferation, inhibits immunoglobulin secretion, and selectively expands certain B-cell subpopulations. (from The On-line Medical Dictionary http://cancerweb.ncl.ac.uk/omd/)
C28603	IFNG_Gene	Signaling_Pathway_Gene	IFNG Gene|IFG|IFI|IFNG|Interferon, Gamma Gene	The gamma or immune IFNs are produced by T lymphocytes in response to mitogens or to antigens to which they are sensitized. They are acid-labile and serologically distinct from alpha- and beta-IFNs. (from OMIM 147570)
C28604	IL15_Gene	Interleukin_Gene	IL15 Gene|IL-15 Gene|Interleukin 15 Gene|Interleukin-15 Gene|Interleukin-15 Precursor Gene|MGC9721 Gene	The IL15 gene at 4q31 encodes Interleukin-15, which is a cytokine that regulates T and natural killer cell activation and proliferation. This cytokine and interleukin 2 share many biological activities. They are found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity. The number of CD8+ memory cells is controlled by a balance between this cytokine and IL2. This cytokine induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6. Three alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported. (From LocusLink)
C28605	IL16_Gene	Interleukin_Gene	IL16 Gene|IL-16 Gene|IL16|Interleukin 16 (Lymphocyte Chemoattractant Factor) Gene|Interleukin 16 Precursor Gene|Interleukin-16 Gene|LCF Gene|Lymphocyte Chemoattractant Factor Gene|prIL-16 Gene	The IL16 gene at 15q26.3 encodes Interleukin-16, which is a pleiotropic cytokine that functions as a chemoattractant, a modulator of T cell activation, and an inhibitor of HIV replication. As a ligand for CD4, the signaling process of this cytokine is mediated by CD4. Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils as well as induces T-lymphocyte expression of interleukin 2 receptor. The product of this gene undergoes proteolytic processing, which yields two functional proteins. The cytokine function is exclusively attributed to the secreted C-terminal peptide, while the N-terminal product may play a role in cell cycle control. Caspase 3 is involved in the proteolytic processing of this protein. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. (From LocusLink, Swiss-Prot and NCI)
C28606	_15q26_3	Chromosome_Band	15q26.3	A chromosome band present on 15q
C28607	LDLR_Gene	Receptor_Gene	LDLR Gene|FH|FHC|LDLR|Low Density Lipoprotein Receptor (Familial Hypercholesterolemia) Gene	The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. (LocusLink)
C28608	IL17_Gene	Interleukin_Gene	IL17 Gene|CTLA-8 Gene|CTLA8 Gene|Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene|Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene|IL-17 Gene|IL-17A Gene|IL17|IL17A Gene|Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene|Interleukin 17 Precursor Gene	The IL17 gene at 6p12 encodes Interleukin-17, which is a proinflammatory cytokine produced by activated T cells. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. (From LocusLink)
C28609	IL18_Gene	Interleukin_Gene	IL18 Gene|IFN-Gamma-Inducing Factor Gene|IGIF Gene|IL-1 Gamma Gene|IL-18 Gene|IL-1g Gene|IL18|IL1F4 Gene|Interferon-Gamma Inducing Factor Gene|Interferon-Gamma-Inducing Factor Gene|Interleukin 18 (Interferon-Gamma-Inducing Factor) Gene|Interleukin 18 Proprotein Gene|Interleukin-1 Gamma Gene|Interleukin-18 Precursor Gene|MGC12320 Gene	The IL18 gene at 11q22.2-q22.3 encodes Interleukin-18, which is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 inhibits IL4 dependent IgE and IgG1 production, and enhances IgG2a production of B cells. IL-18 binding protein (IL18BP) can specifically interact with this cytokine, and thus negatively regulate its biological activity. (From LocusLink)
C28610	KLRA1_Gene	Receptor_Gene	KLRA1 Gene|KLRA1|Killer Cell Lectin-Like Receptor Subfamily A, Member 1 Gene|LY49|LY49L	A surface receptor on NK cells involved in binding to MHC Class I molecules presented on somatic cells as part of a recognition mechanism.
C28611	_12p13-p12	Chromosome_Band	12p13-p12	A chromosome band present on 12p
C28612	IL19_Gene	Interleukin_Gene	IL19 Gene|IL-10C Gene|IL-19 Gene|IL19|Interleukin 19 Gene|Interleukin 19 Precursor Gene|Interleukin-19 Gene|Interleukin-19 Precursor Gene|MDA1 Gene|Melanoma Differentiation Associated Protein-Like Protein Gene|NG.1 Gene|ZMDA1 Gene	The IL19 gene at 1q32.2 encodes Interleukin-19, which is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. (From LocusLink)
C28613	Interleukin-19	Interleukin	Interleukin-19|IL-10C|IL-19|IL19|IL19 Protein|Interleukin 19|Interleukin 19 Precursor|Interleukin-19 Precursor|MDA1|Melanoma Differentiation Associated Protein-Like Protein|NG.1|ZMDA1	Interleukin-19, encoded by the IL19 gene, is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. (From LocusLink)
C28614	Transcription_Process	Gene_Expression_Process	Transcription Process	A Transcription Process is any cellular event or activity directly involved in the synthesis a nascent RNA transcript.
C28615	Transcription_Termination	Transcription_Process	Transcription Termination	Transcription Termination is the cessation of cellular activities involved in the synthesis a nascent RNA transcript.
C28616	E7_86-93_Lipopeptide	Retired_Concepts	E7(86-93) Lipopeptide	Lipidated cytotoxic T-cell epitopes of Human Papilloma Virus Type 16 E7 for use in Vaccine Therapy. (NCI)
C28619	Mouse_Pulmonary_Disorder	Mouse_Respiratory_System_Disorder	Mouse Pulmonary Disorder|Pulmonary Disorder
C28620	Pulmonary_Proliferative_Lesions_of_the_Mouse	Mouse_Pulmonary_Disorder	Pulmonary Proliferative Lesions of the Mouse|Pulmonary Proliferative Lesions
C28621	Epithelial_Proliferative_Lesions_of_the_Mouse_Pulmonary_System	Pulmonary_Proliferative_Lesions_of_the_Mouse	Epithelial Proliferative Lesions of the Mouse Pulmonary System|Epithelial Proliferative Lesions of the Pulmonary System
C28622	Airway_Epithelial_Hyperplasia_of_the_Mouse_Pulmonary_System	Epithelial_Hyperplasia_of_the_Mouse_Pulmonary_System	Airway Epithelial Hyperplasia of the Mouse Pulmonary System|Airway Epithelial Hyperplasia of the Pulmonary System	Number of respiratory epithelial cells is increased diffusely or focally.  Frequently luminal protrusions are observed, sometimes forming papillae.  Mucous (goblet) cell metaplastic hyperplasia is a variant, in which the respiratory epithelium of conducting airways is replaced by mucous cells either as a single or a pseudostratified layer.
C28623	Alveoli_Epithelial_Hyperplasia_of_the_Mouse_Pulmonary_System	Epithelial_Hyperplasia_of_the_Mouse_Pulmonary_System	Alveoli Epithelial Hyperplasia of the Mouse Pulmonary System|Alveoli Epithelial Hyperplasia of the Pulmonary System	Solitary or multiple foci of increased cellularity distal to terminal bronchioles.  The background of broncho-alveolar architecture remains detectable, and epithelial cells are usually single layered.  Round to oval hypertrophic type II pneumocytes with abundant eosinophilic cytoplasm line alveolar walls.  In bronchiolar subvariant, also called bronchiolization of alveoli, alveolar walls are lined by cuboidal to columnar cells with features of bronchiloar differentiation such as formation of cilia, Clara cell resemblance and presence of mucous granules.  Foci of consolidation may indicate early stages of adenoma formation.  Macrophages may be present in the alveolar lumens.
C28624	Immunoglobulin_Family_Protein	Protein_Organized_by_Structure	Immunoglobulin Family Protein	Encoded by Immunoglobulin Family Genes, structurally-related Immunoglobulin Family Proteins contain one, or more, 100-aa Immunoglobulin domain that includes a conserved intradomain disulfide bond and may be involved in protein-protein or protein-ligand interactions. Immunoglobulin Family members include hundreds of functionally diverse proteins, such as Immunoglobulins, the muscle kinase titin, and receptor tyrosine kinases. (NCI)
C28625	Diffuse_Idiopathic_Pulmonary_Neuroendocrine_Cell_Hyperplasia_of_the_Mouse_Pulmonary_System	Preinvasive_Lesions_of_the_Mouse_Pulmonary_System	Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia of the Mouse Pulmonary System|Diffuse Idiopathic Pulmonary Hyperplasia of the Mouse Pulmonary System|Diffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia	Diffuse accumulation of groups of neuroendocrine cells confined to bronchiolar epithelium in the absence of airway inflammation or diffuse interstitial fibrosis. Not reported to occur spontaneously.
C28626	MAD_Gene	Transcription_Corepressor_Gene	MXD1 Gene|MAD|MAD Gene|MAD Protein (MAX-Binding Protein) Gene|MAX Dimerization Protein 1 Gene|MAX Dimerization Protein Gene|MAX Dimerizer Gene|MXD1	The MAD gene at 2p13-p12 encodes MAX Dimerization Protein 1, which belongs to a subfamily of MAX-interacting proteins. MAD competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex. MAD acts as a transcriptional repressor while MYC appears to function as an activator) and is a candidate tumor suppressor gene. (from LocusLink and NCI)
C28627	MAX_Dimerization_Protein-1	Transcription_Repressor_Corepressor	MAX Dimerization Protein 1	MAX Dimerization Protein 1, encoded by the MAD gene, belongs to a subfamily of MAX-interacting proteins. MAD competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex. MAD acts as a transcriptional repressor while MYC appears to function as an activator) and is a candidate tumor suppressor gene. (from LocusLink and NCI)
C28628	PCNA_Gene	Cell_Cycle_Gene	PCNA Gene|MGC8367|PCNA|Proliferating Cell Nuclear Antigen Gene	The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. (from LocusLink)
C28629	MLANA_Gene	Gene_with_Unknown_or_Unclassified_Function	MLANA Gene|Antigen LB39-AA Gene|Antigen SK29-AA Gene|MART-1 Antigen Gene|MART-1 Gene|MART1 Gene|MLANA|Melan A Gene|Melan-A Gene|Melan-A Protein Gene|Melanoma Antigen Recognized by T Cells 1 Gene|Melanoma Antigen Recognized by T-Cells 1 Gene	Expressed in melanocytes and retina, 5-exon 18.5-kb human MLANA Gene encodes 118-aa 13-kDa Pro-rich Melan-A Protein, an antigen recognized by cytolytic T lymphocytes and containing no leader sequence but having a putative transmembrane hydrophobic stretch, that may bind HLA-A2, followed by 3 Arg residues. (NCI)
C28630	_9p24_1	Chromosome_Band	9p24.1	A chromosome band present on 9p
C28631	Antitumor_Response	Immune_Response	Antitumor Response	An Antitumor Response involves destruction of cancer tumor cells primarily by activated T-cells induced to react to antigens recognized as foreign and expressed by the transformed cells.
C28632	PURA_Gene	Ligand_Binding_Protein_Gene	PURA Gene|PUR-Alpha|PUR1|PURA|PURALPHA|Purine-Rich Element Binding Protein A Gene	This gene encodes a sequence-specific, single-stranded DNA-binding protein. It binds preferentially to the single strand of the purine-rich element termed PUR, which is present at origins of replication and in gene flanking regions in a variety of eukaryotes from yeasts through humans. Thus, it is implicated in the control of both DNA replication and transcription. Deletion of this gene has been associated with myelodysplastic syndrome and acute myelogenous leukemia. (from LocusLink)
C28633	NCOR2_Gene	Transcription_Corepressor_Gene	NCOR2 Gene|CTG26|NCOR2|Nuclear Receptor Co-Repressor 2 Gene|SMRT|SMRTE|TNRC14|TRAC-1|TRAC1	SMRT is a receptor-interacting factor for retinoid and thyroid-hormone receptors. The repressor function of thyroid hormone and retinoic acid receptors involves direct interaction with SMRT, possibly by stabilizing/promoting interaction with transcription factor TFIIB. Ligand causes SMRT dissociation from the receptor, triggering activation. Binding of ligand to nuclear hormone receptors induces a conformation that attracts co-activator proteins containing a NR box. NCOR1 has a similar NR box, CoRNR box, that is required for nuclear hormone receptor interaction. Sequences flanking the corner box determine nuclear hormone receptor specificity. Hormone action and differential recognition of unliganded and liganded nuclear hormone receptors by co-activators and co-repressors appears to be due to subtle differences between CoRNR and NR boxes. (from OMIM 600848 and NCI)
C28634	_12q24	Chromosome_Band	12q24	A chromosome band present on 12q
C28635	ZNF145_Gene	Transcription_Corepressor_Gene	ZBTB16 Gene|PLZF|ZBTB16|ZNF145|ZNF145 Gene|Zinc Finger and BTB Domain Containing 16 Gene	Induced by retinoic acid in early myeloid cells, peripheral mononuclear cells, and in ovary, kidney, and lung, human ZNF145 Gene (Krueppel Family) encodes alternative isoforms PLZFA (550-aa) and PLZFB (673-aa, 74-kDa) of nuclear Zinc Finger Protein 145, a probable transcription factor containing a BTB/POZ domain. Conserved N-terminal protein interaction BTB/POZ domains of some C2H2 transcription factors interact with components of histone deacetylase complex and repress transcription. ZNF145 may play a role in myeloid maturation and development, or maintenance of differentiated tissues. A growth-inhibitory and pro-apoptotic factor in limb bud formation, ZNF145 is an axial and appendicular skeletal anterior/posterior patterning mediator that regulates HOX gene expression. APL associated translocation t(11;17)(q32;q21) involves ZNF145 and RARA. (NCI)
C28636	MKI67_Gene	Cell_Cycle_Gene	MKI67 Gene|Antigen Identified by Monoclonal Antibody Ki-67 Gene|Antigen KI-67 Gene|KIA Gene|MKI67|Proliferation-Related Ki-67 Antigen Gene	The MKI67 gene at 10q25-qter encodes Antigen Identified by Monoclonal Antibody Ki-67, which is a nuclear antigen expressed in proliferating cells but not in quiescent cells, and required for maintaining cell proliferation. Expression of this antigen occurs preferentially during late G1, S, G2, and M phases of the cell cycle, while in cells in G0 phase the antigen cannot be detected. Consequently, the monoclonal antibody Ki-67 is used in tumor pathology to detect proliferating cells in neoplastic diseases. This antigen is located in the nucleus, predominantly localized in the G1 phase in the perinucleolar region. In the later phases it is also detected throughout the nuclear interior, being predominantly localized in the nuclear matrix. In mitosis, it is present on all chromosomes. This antigen contains 1 FHA domain. Two alternative splicing forms exist, Long and Short. (from Swiss-Prot)
C28637	_10q25-qter	Chromosome_Band	10q25-qter	A chromosome band present on 10q
C28638	SSTR2_Gene	G_Protein-Coupled_Receptor_Gene	SSTR2 Gene|SSTR2|Somatostatin Receptor 2 Gene	Somatostatin binds to a group of structurally related tissue-specific high-affinity integral membrane GPCRs (family 1), coupled via G proteins to inhibition of adenylyl cyclase.  Somatostatin Receptor 2 is expressed highest in the cerebrum and kidney and inhibits DNA synthesis and cell proliferation.  SSTR2 appears to antagonize SSTR5, and vice versa, suggesting a tissue-specific function and interaction between these receptors.  SSTR2 stimulates phosphotyrosine phosphatase and PLC via G proteins.  It also appears to suppress voltage dependent calcium-channels.  Two isoforms are produced by alternative splicing.  (from OMIM 182452, SWISS-PROT P30874, and NCI)
C28639	SSTR5_Gene	G_Protein-Coupled_Receptor_Gene	SSTR5 Gene|SSTR5|Somatostatin Receptor 5 Gene	Somatostatin binds to a group of structurally related tissue-specific high-affinity integral membrane GPCRs (family 1), coupled via G proteins to inhibition of adenylyl cyclase.  The Somatostatin Receptor 5 and D2R GPCRs interact to create a novel receptor with enhanced activity; either ligand promotes heterodimerization.  SSTR5 increases DNA synthesis, whereas SSTR2 inhibits DNA synthesis and cell proliferation.  SSTR2 appears to antagonize SSTR5, and vice versa, suggesting a tissue-specific function and interaction between these receptors.  SSTR5 is expressed in adult pituitary gland, heart, small intestine, adrenal gland, cerebellum and fetal hypothalamus.  (from OMIM 182455, SWISS-PROT P35346, and NCI)
C28640	NCOR1_Gene	Transcription_Corepressor_Gene	NCOR1 Gene|KIAA1047 Gene|N-CoR Gene|N-CoR1 Gene|NCOR1|Nuclear Receptor Co-Repressor 1 Gene|Nuclear Receptor Corepressor 1 Gene|TRAC1 Gene|Thyroid Hormone- and Retinoic Acid Receptor-Associated Corepressor 1 Gene|hCIT529I10|hN-CoR Gene	The NCOR1 gene at 10q25-qter encodes Nuclear Receptor Co-Repressor 1, which mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. This protein is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined. (from LocusLink)
C28641	Hospice_Nursing	Palliative_Care_Nursing	Hospice Nursing|End-of-life Nursing	Nursing specialized in providing palliative care for terminally ill patients.  It includes support for both the patient and their family.
C28642	Minichromosome_Maintenance_Protein-2	MCM_Protein	Minichromosome Maintenance Protein 2|BM28|CCNL1|CDCL1|Cell Devision Cycle-Like 1|Cyclin-Like 1|D3S3194|DNA Replication Licensing Factor MCM2|KIAA0030|MCM2|MCM2 Minichromosome Maintenance Deficient 2, Mitotin (S. cerevisiae)|MCM2 Protein|MGC10606|Minichromosome Maintenance, S. cerevisiae, Homolog of, 2|Mitotin|Nuclear Protein BM28|cdc19	Minichromosome Maintenance Protein 2 (MCM2) is encoded by the MCM2 gene. This 100-kD nuclear protein allows the DNA to undergo a single round of replication per cell cycle and is required for the entry in S phase and for cell division. MCM4, MCM6, and MCM7 form a stable complex with which MCM2 is loosely associated. The trimeric complex of MCM4, -6, and -7 has ATPase and DNA helicase activities, which is involved in the initiation of DNA replication as a DNA unwinding enzyme. The presence of MCM2 disturbs the assembly of MCM4, MCM6, and MCM7 proteins to inhibit the DNA helicase activity. Through specific binding of MCM2 with histone H3, the complex binds chromatin. In addition, the CDC7L1 kinase complex triggers S phase by directly activating the replication initiation complex assembled at the origins. Phosphorylation of MCM2 and MCM3 in the MCM complex by the CDC7L1 kinase complex converts the inactive MCM complex into an active helicase. (NCI)
C28643	NID_Gene	Extracellular_Matrix_Protein_Gene	NID Gene|ENTACTIN|NID|NID1|Nidogen (Enactin) Gene	The NID gene encodes nidogen (entactin), a 150-kD sulfated glycoprotein that is a major component of basement membranes and forms a highly stable noncovalent complex with laminin. Vasculostatin, a 20 kDa C-terminal fragment of nidogen, has anti-angiogenesis activity. (from OMIM and NCI)
C28644	_1q43	Chromosome_Band	1q43	A chromosome band present on 1q
C28645	Nidogen	Extracellular_Matrix_Protein	Nidogen|Entactin|NID	Entactin, a 150-kD sulfated glycoprotein, is a major component of basement membranes and forms a highly stable noncovalent complex with laminin.  It is encoded by the NID gene. Vasculostatin, a 20 kDa C-terminal fragment of nidogen, has anti-angiogenesis activity. (from OMIM and NCI)
C28646	RELA_Gene	Transcription_Factor_Gene	RELA Gene|NFKB3|RELA|v-REL Reticuloendotheliosis Viral Oncogene Homolog A, Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells 3, p65 (Avian) Gene	The 10-exon 8-kb human RELA Gene (Rel/Dorsal Family) at 11q12-q13 encodes NF-Kappa B p65 (551-aa), an NFKB subunit, containing rel homology regions, an alpha helical segment, and NLS, that activates transcription as a heterodimer with a 50-kd DNA-binding (kappa-B motif) subunit. Alternatively spliced p65 Delta 2 (537-aa) is also produced. Cytoplasmic NFKB, sequestered by IKB interaction with p65, translocates to the nucleus on IKBKA/B-dependent ubiquitinated destruction of IKB. p65 ser276 phosphorylation by PKA stimulates coactivator CBP/p300 interaction and transcriptional activity. NFKB(pp65) associates with CBP and displaces DNA bound p50-HDAC1 complexes that suppress gene expression. Through N-terminal association, HDAC3 inhibits p65, abolishes CBP/p300 RELA acetylation, and promotes XPO1-dependent RELA/IKBA binding for nuclear export. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28647	_11q12-q13	Chromosome_Band	11q12-q13	A chromosome band present on 11q
C28648	_1q22-q23	Chromosome_Band	1q22-q23	A chromosome band present on 1q
C28649	POU2F1_Gene	Transcription_Factor_Gene	POU2F1 Gene|OCT1|OTF1|POU Domain, Class 2, Transcription Factor 1 Gene|POU2F1	The 195-kb 16-exon human POU2F1 Gene (POU2 Family) at 1q22-q23, near CD3Z, expresses alternative splice forms: a ubiquitous isoform 1 (743-aa, 76.5-kD) and a 755-aa lymphocyte-specific isoform 2. The ubiquitous transcription factor gene product OTF-1 contains one homeobox domain, binds to the octamer ATTTGCAT motif, and activates genes for some snRNA, histone H2B, and immunoglobulins. POU domain proteins contain a bipartite DNA-binding domain divided by a flexible linker that enables diverse monomeric configurations on DNA; additional versatility is conferred by dimerization. OTF-1 POU dimers on palindromic OCT factor recognition elements, or PORE, (ATTTGAAATGCAAAT) can recruit transcriptional coactivator OBF1. OTF-1 interacts with transcription activators NR3C1, AR, and PGR. (from LocusLink, Swiss-Prot, and NCI)
C28650	_19q13_31	Chromosome_Band	19q13.31	A chromosome band present on 19q
C28651	POU2F2_Gene	Transcription_Factor_Gene	POU2F2 Gene|OCT2|OTF2|POU Domain, Class 2, Transcription Factor 2 Gene|POU2F2	The 41.5-kb human POU2F2 Gene (POU2 Family) at 19q13.31 expresses alternative splice isoforms 1 (478-aa, 51-kD), 2 (466-aa), 3 (462-aa), and 4 (399-aa) of transcription factor OTF-2, which contains a DNA binding homeobox domain, binds to octamer motif ATTTGCAT, and regulates Ig gene expression and transcription in several other tissues. OTF-2 also interacts with transcription activators NR3C1, AR, and PGR. Neuronal NOS gene is a target of OTF-2. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28652	TRADD_Gene	Adaptor_Signaling_Protein_Gene	TRADD Gene|TNFRSF1A-Associated via Death Domain Gene|TRADD	The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. (from LocusLink)
C28653	TRAF2_Gene	Adaptor_Signaling_Protein_Gene	TRAF2 Gene|MGC:45012|TNF Receptor-Associated Factor 2 Gene|TRAF2|TRAP|TRAP3	The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, targets degradation of this protein, and thus potentiates TNF-induced apoptosis. (from LocusLink)
C28654	Retrograde_Pyelogram	Medical_Image	Retrograde Pyelogram	Radiographic image of the ureters and collecting system of the kidneys after introduction of a dye opaque to xrays by way of a urinary catheter. (from http://www.hyperdictionary.com/medical/retrograde+pyelogram)
C28655	PLCG2_Gene	Esterase_Gene	PLCG2 Gene|PLCG2|Phospholipase C, Gamma 2 (Phosphatidylinositol-Specific) Gene	Human PLCG2 Gene encodes 1265-aa 148-kDa Phospholipase C Gamma 2, a crucial enzyme that generates DAG and IP3 second messengers in the transmembrane signaling of ligand-activated growth factor receptors. Containing a PI-PLC X-box catalytic domain, a PI-PLC Y-box catalytic domain, a C2 domain, a PH domain, 2 SH2 domains, and an SH3 domain, PLCG2 phospholipase activity increases upon phosphorylation on tyrosine residues following activation of growth factor and immune system receptors. (NCI)
C28656	PGR_Gene	Nuclear_Receptor_Gene	PGR Gene|NR3C3|PGR|PR|Progesterone Receptor Gene	This gene encodes progesterone receptor that is a member of nuclear hormone receptor family of ligand-induced transcription factors. Progesterone receptor, can activates transcription from PRE-containing promoters. (NCI)
C28657	PRLR_Gene	Receptor_Gene	PRLR Gene|PRLR|Prolactin Receptor	This gene encodes prolactin receptor which binds prolactin. The prolactin receptor is homologous to members of the cytokine receptor superfamily, such as GHR, IL2R, IL3R, IL4R, IL6R, IL7R, EPOR, and GMCSFR.  PRLR isoforms differ in the length of their cytoplasmic domains.  The short form acts as a dominant-negative inhibitor, forming inactive heterodimers that inhibit Janus kinase 2 activation.  (from OMIM 176761 and NCI)
C28658	Telomeric_Repeat_Binding_Factor-2	Telomeric-Repeat_Binding_Factor	Telomeric Repeat Binding Factor 2|TERF2|Telomeric-Repeat Binding Factor 2	This protein is a telomere specific binding protein which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. (LocusLink)
C28659	Signal_Transducer_and_Activator_of_Transcription-1	Signal_Transducer_and_Activator_of_Transcription	Signal Transducer and Activator of Transcription 1|STAT1	This protein is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. (LocusLink)
C28660	Signal_Transducer_and_Activator_of_Transcription-2	Signal_Transducer_and_Activator_of_Transcription	Signal Transducer and Activator of Transcription 2|STAT2	This protein is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. (LocusLink)
C28661	THBS1_Gene	Regulatory_Gene	THBS1 Gene|THBS1|TSP Gene|TSP1 Gene|Thrombospondin 1 Gene|Thrombospondin-1 Gene	The THBS1 gene at 15q15 encodes Thrombospondin 1, a member of the thrombospondin family. Thrombospondin 1 is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. It can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1, alpha-V/beta-3 and alpha-IIb/beta-3. It forms a disulfide-linked homotrimer and contains 3 EGF-like domains, 3 TSP type-1 domains, 7 TSP type-3 domains, and 1 TSP N-terminal (TSPN) domain. (from Swiss-Prot)
C28662	_15q15	Chromosome_Band	15q15	A chromosome band present on 15q
C28663	THBS2_Gene	Regulatory_Gene	THBS2 Gene|THBS2|TSP2 Gene|Thrombospondin 2 Gene|Thrombospondin II Gene|Thrombospondin-2 Gene	The THBS2 gene at 6q27 encodes Thrombospondin 2, a member of the thrombospondin family. Thrombospondin 2 is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. It can bind to fibrinogen, fibronectin, laminin and type V collagen. It forms a disulfide-linked homotrimer. (from Swiss-Prot)
C28664	Signal_Transducer_and_Activator_of_Transcription-3	Signal_Transducer_and_Activator_of_Transcription	Signal Transducer and Activator of Transcription 3|APRF|Acute-Phase Response Factor|STAT3	This protein is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. (LocusLink)
C28665	Signal_Transducer_and_Activator_of_Transcription-4	Signal_Transducer_and_Activator_of_Transcription	Signal Transducer and Activator of Transcription 4|STAT4	This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. (LocusLink)
C28666	Placental_Growth_Factor	Growth_Factor	Placental Growth Factor|PGF|PLGF-2|PlGF	Placental Growth Factor, encoded by the PGF gene, belongs to the PDGF/VEGF growth factor family. Placental Growth Factor is active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration. Three isoforms exist from alternative splicing. (From LocusLink)
C28667	STAT5B_Gene	Signal_Transducer_and_Activator_of_Transcription_Family_Gene	STAT5B Gene|MGF|STAT5B	The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. (LocusLink)
C28668	Signal_Transducer_and_Activator_of_Transcription-5A	Signal_Transducer_and_Activator_of_Transcription	Signal Transducer and Activator of Transcription 5A|STAT1|STAT5A	This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart is found to induce the expression of BCL2L1/BCL-X(L), which suggests an antiapoptotic function in cells. (from LocusLink)
C28669	Signal_Transducer_and_Activator_of_Transcription-5B	Signal_Transducer_and_Activator_of_Transcription	Signal Transducer and Activator of Transcription 5B|STAT5B	This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. The gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. (LocusLink)
C28670	Signal_Transducer_and_Activator_of_Transcription-6	Signal_Transducer_and_Activator_of_Transcription	Signal Transducer and Activator of Transcription 6|STAT6|Transcription Factor IL-4 STAT	This protein is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this protein in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins. (LocusLink)
C28671	Activator_of_S_Phase_Kinase	Regulatory_Protein	Activator of S Phase Kinase|ASK|DBF4 Homolog|Dumbbell Former 4 Homolog	Encoded by growth factor and E2F-regulated widely expressed human ASK Gene, 77-kD nuclear Activator of S Phase Kinase (dup) is a cyclin-like regulatory subunit of CDC7L1 kinase involved in G1/S transition. ASK mRNA and protein are low in G1, peak in S phase, and reduce in G2/M; ASK is extensively phosphorylated during S phase. Containing a bipartite NLS, conserved motifs N (N-terminus) and C (central region), and 2 PEST sequences, ASK appears essential for entry into S phase. Motif C is essential for CDC7L1 catalytic subunit interaction with ASK, a major activator of CDC7L1 kinase activity on MCM2.  (NCI)
C28672	CDC7L1_Kinase_Complex	Protein_or_Riboprotein_Complex	CDC7L1 Kinase Complex	The G1/S transition in eukaryotic cells is strictly regulated so that DNA replication occurs only once during S phase. The CDC7L1 kinase complex may trigger S phase by directly activating the replication initiation complexes assembled at the origins. Phosphorylation of MCM2 and MCM3 in the MCM complex by the CDC7L1 kinase complex converts the inactive MCM complex into an active helicase. Activator of S Phase Kinase, encoded by the ASK gene, is a cyclin-like regulatory subunit of the CDC7L1 kinase complex. This protein is the major activator of CDC7L1. ASK plays a pivotal role in the G1/S transition in mammalian cells and its function is essential for entry into S phase. ASK interacts with CDC7L1 and stimulates the kinase activity of CDC7L1. CDC7L1-dependent kinase activity reflects the ASK protein level, significantly increasing in cells in S phase, and ASK protein is extensively phosphorylated during S phase, presumably by CDC7L1.
C28673	CDC45-Related_Protein	Regulatory_Protein	CDC45-Related Protein|CDC45|CDC45 (Cell Division Cycle 45, S. cerevisiae, Homolog)-Like|CDC45 Cell Division Cycle 45-Like (S. cerevisiae)|CDC45-Like|CDC45L|CDC45L2|Cell Division Cycle 45, S. cerevisiae, Homolog-Like|Cell Division Cycle 45-Like 2|PORC-PI-1	CDC45-Related Protein, encoded by the CDC45L gene, was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. CDC45-Related Protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggest that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. (from LocusLink)
C28674	_22q12_1-q13_2	Chromosome_Band	22q12.1-q13.2	A chromosome band present on 22q
C28675	TIMP1_Gene	Regulatory_Gene	TIMP1 Gene|CLGI|EPA|EPO|HCI|TIMP|TIMP1|Tissue Inhibitor of Metalloproteinase 1 (Erythroid Potentiating Activity, Collagenase Inhibitor) Gene	Highly inducible by cytokines and hormones, 4.5-kb human TIMP1 Gene (TIMP Family) at Xp11.3-p11.23 contains at least 2 introns and encodes TIMP-1, a 207-aa 28-kD secreted glycoprotein growth factor expressed by platelets and macrophages that mediates erythropoiesis. TIMP-1 tightly complexes with and inhibits interstitial collagenase activity as well as connective tissue metalloendoproteases, involved in extracellular matrix degradation and connective tissue remodeling. Located about 22 cM proximal to OTC, TIMP1 resides within intron 6 of SYN1 and is transcribed in the opposite direction. ARAF1, ELK1, ZNF41, and ZNF157 lie within 100-kb of TIMP1. X inactivation of TIMP1 appears polymorphic in human females. Activity dependent on disulfide bonds, TIMP1 acts on MMP-1, -2, -3, -7, -8, -9, -10, -11, -12, -13 and -16. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28676	Allogeneic_Lymphocytes	Biological_Agent	Therapeutic Allogeneic Lymphocyte|Allogeneic Lymphocytes	A population of lymphocytes therapeutically administered to a recipient individual who is genetically distinct from a donor of the same species. (NCI04)
C28677	Replication_Initiation	Replication-Associated_Process	Replication Initiation|DNA Replication Initiation	DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA. (from MedLine 11395402)
C28678	CDC7_Cell_Division_Cycle-7_Protein	Regulatory_Protein	CDC7 Cell Division Cycle 7|CDC7|CDC7 Cell Division Cycle 7 (S. cerevisiae)|CDC7 Cell Division Cycle 7-Like 1 (S. cerevisiae)|CDC7-Related Kinase|CDC7L1|Cell Division Cycle 7, S. cerevisiae, Homolog-Like 1|Cell Division Cycle 7-Related Protein Kinase|EC 2.7.1.-|HsCDC7|Hsk1|huCDC7	CDC7 Cell Division Cycle 7, encoded by the CDC7 gene, is predominantly localized in the nucleus and is a cell division cycle protein with kinase activity. Although expression levels of this protein appear constant throughout the cell cycle, the protein kinase activity appears to increase during S phase. This protein is essential for initiation of DNA replication and plays a role in regulating cell cycle progression. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Additional transcript sizes have been detected, suggesting the presence of alternative splicing. (From LocusLink and NCI)
C28679	TIMP2_Gene	Regulatory_Gene	TIMP2 Gene|TIMP2|Tissue Inhibitor of Metalloproteinase 2 Gene	The 83-kb 5-exon constitutive human TIMP2 Gene (TIMP Family) at 17q25 encodes 207-aa 28-kD secreted TIMP-2 protein, containing 12 cysteines and 3 conserved tryptophans. TIMP1, 2, and 3 splice sites are conserved. The TIMP2 5-prime region contains Sp1, AP2, AP1, and PEA3 regulatory elements. The 1.2- and 3.8-kb mRNAs employ different polyadenylation sites, which do not affect RNA stability. Activity dependent on disulfide bonds, TIMP-2 complexes with and inactivates matrix metalloproteinases, involved in extracellular matrix degradation and connective tissue remodeling. TIMP family members may possess selective affinities for matrix metalloproteinases and TIMP-2 may play a different role from TIMP-1 or TIMP-3. TIMP-2 inhibits type IV collagenase in a stoichiometric fashion and acts on MMP-1, -2, -3, -7, -8, -9, -10, -13, -14, -15, -16 and -19. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28680	TIMP3_Gene	Regulatory_Gene	TIMP3 Gene|HSMRK222|K222TA2|SFD|TIMP3|Tissue Inhibitor of Metalloproteinase 3 (Sorsby Fundus Dystrophy, Pseudoinflammatory) Gene	Mitogenically induced and cell cycle regulated, widely expressed 62-kb 5-exon human TIMP3 Gene (TIMP Family) at 22q12.1-q13.2 encodes 27-kD glycosylated TIMP-3, an angiogenesis inhibitor containing 12 conserved cysteines, localized in the ECM, and similar to TIMP-1 and TIMP-2. TIMP-3 complexes with and inactivates matrix metalloproteinases, involved in extracellular matrix degradation. TIMP family members may possess selective affinities for matrix metalloproteinases. Likely part of acute response tissue-specific remodeling, TIMP-3 acts on MMP-1, -2, -3, -7, -9, -13, -14 and -15. The N-terminus inhibits MMPs; the C-terminus mediates specific molecular functions. TIMP3 inhibits VEGF-mediated angiogenesis; it blocks VEGF binding to VEGFR2. Gene mutations cause Sorsby fundus dystrophy. (from LocusLink, Swiss-Prot, OMIM, and NCI)
C28681	Autologous_Lymphocytes	Biological_Agent	Therapeutic Autologous Lymphocytes	A population of lymphocytes isolated from an individual, altered in vitro, and returned to the same individual for therapeutic purposes. (NCI04)
C28682	AUT-OV-ALVAC-hB7_1_Vaccine	Autologous_Cell_Vaccine	AUT-OV-ALVAC-hB7.1 Vaccine|AUT-OV-ALVAC-hB7.1	A vaccine comprised of autologous epithelial ovarian cells infected with ALVAC-hB7.1. (NCI)
C28683	Cell_Cycle_Progression	Cell_Division_Process	Cell Cycle Progression	The cell cycle is an ordered set of events. Progression through the stages of cell cycle, including G1-S-G2-M, culminates in cell growth and division into two daughter cells. The G1 stage stands for "GAP 1". The S stage stands for "Synthesis". This is the stage when DNA replication occurs. The G2 stage stands for "GAP 2". The M stage stands for "mitosis", and is when nuclear (chromosomes separate) and cytoplasmic (cytokinesis) division occur. (NCI)
C28684	Minichromosome_Maintenance_Protein-3	MCM_Protein	Minichromosome Maintenance Protein 3	Minichromosome Maintenance Protein 3, encoded by the MCM3 gene, is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. (From LocusLink)
C28685	Pre-Replication_Complex	Protein_or_Riboprotein_Complex	Pre-Replication Complex|pre-RC	The Origin Recognition Complex (ORC) in eukaryotic cells selects genomic sites where pre-replication complexes (pre-RCs) can be assembled. Subsequent activation of these pre-RCs results in bi-directional DNA replication that originates at or close to the ORC DNA binding sites. (From PubMed 12801628)
C28686	Transcriptional_Co-Activator-CRSP150	Protein_Complex_Subunit	Cofactor Required for Sp1 Transcriptional Activation Subunit 2|CRSP2	Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP2 gene at Xp11.4-p11.2 encodes a 150-kD protein that is subunit 2 of the CRSP complex. This CRSP2 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. CRSP2 contains a cytochrome C family heme-binding motif and a bipartite nuclear localization signal. (from OMIM 300182, LocusLink 9282)
C28687	Cofactor_Required_for_SP1_Activation	Transcription_Coactivator	Cofactor Required for SP1 Activation|CRSP Complex	A protein complex, which, along with TFIID, is required for efficient transcriptional activation by SP1.
C28688	Transcriptional_Co-Activator-CRSP130	Protein_Complex_Subunit	Cofactor Required for Sp1 Transcriptional Activation Subunit 3|CRSP3	Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation) along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP3 gene encodes this 130-kD protein that is subunit 3 of the CRSP complex. The CRSP3 protein is required for Sp1 mediated transcriptional activation with TAF(II)s. (from OMIM 605042, LocusLink 9439)
C28689	Transcriptional_Co-Activator-CRSP77	Protein_Complex_Subunit	Cofactor Required for Sp1 Transcriptional Activation Subunit 6|CRSP6	Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP6 gene at 11q14 encodes this 80-kD protein that is subunit 6 of the CRSP complex. This CRSP6 protein is required for Sp1 mediated transcriptional activation with TAF(II)s.
C28690	Transcriptional_Co-Activator-CRSP70	Protein_Complex_Subunit	Cofactor Required for Sp1 Transcriptional Activation Subunit 7|CRSP7	Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP6 gene at 11q14 encodes this 80-kD protein that is subunit 6 of the CRSP complex. This CRSP6 protein is required for Sp1 mediated transcriptional activation with TAF(II)s.
C28691	Transcriptional_Co-Activator-CRSP34	Protein_Complex_Subunit	Cofactor Required for Sp1 Transcriptional Activation Subunit 8|CRSP8	Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), which, along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD. Nine polypeptides have been identified as CRSP subunits. The CRSP8 gene encodes this 34-kD protein that is subunit 8 of the CRSP complex. The CRSP8 protein is required for Sp1-mediated transcriptional activation with TAF(II)s. (from OMIM 605044, LocusLink 9442)
C28692	Transcriptional_Co-Activator-CRSP33	Protein_Complex_Subunit	Cofactor Required for Sp1 Transcriptional Activation Subunit 9|CRSP9	Gene transcription requires factors that recognize transcriptional enhancer sites in DNA. These factors work with coactivators to direct transcriptional initiation by the RNA polymerase II apparatus. Transcriptional activation by enhancer-binding factors such as SP1 requires interaction with the TFIID complex. A multisubunit cofactor, CRSP (cofactor required for SP1 activation), along with TFIID, is required for efficient activation by SP1. CRSP behaves as a single complex of approximately 700 kD and 9 polypeptides have been identified as CRSP subunits. The CRSP9 gene encodes this 33-kD protein that is subunit 9of the CRSP complex. The CRSP9 protein is required with the TAF(II)s for Sp1-mediated transcriptional activation. (from OMIM 605045, LocusLink 9443)
C28693	CRYPTIC_Protein	Epidermal_Growth_Factor_Superfamily_Protein	CRYPTIC Protein|CFC1|CRYPTIC	This protein is a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family. EGF-CFC family member proteins share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. These proteins play key roles in intercellular signaling pathways during vertebrate embryogenesis. Mutations in this gene can cause autosomal visceral heterotaxy. This protein is involved in left-right asymmetric morphogenesis during organ development. (LocusLink)
C28694	beta-Lapachone	Topoisomerase-I_Inhibitor	beta-Lapachone|3,4-Dihydro-2,2-dimethyl-2H-naphtho(1,2-b)pyran-5,6-dione|b-Lapachone	A lipophilic o-naphthoquinone plant product isolated from the Lapacho tree.  beta-Lapachone binds to and inhibits topoisomerase I, resulting in DNA replication inhibition and apoptosis.  Induction of apoptosis may be the result of a p53- and caspase-independent mechanism. (NCI)
C28696	Therapeutic_70-kD_Heat-Shock_Protein	Vaccine_Antigen	Recombinant 70-kD Heat-Shock Protein|70-kD Heat-Shock Protein|HSP70|Heat Shock Protein 70	A recombinant peptide that is chemically identical to or similar to the endogenous 70-kD heat shock protein (HSP70).  HSP70 is a molecular chaperone that prevents physiologic stress-induced cell death by inhibiting both caspase-dependent and caspase-independent apoptosis.  Because this peptide is often overexpressed in tumor cells, autologous vaccination with HSP70 derived from tumor cells may stimulate the host immune system to mount a tumoricidal cytotoxic T lymphocyte (CTL) response. (NCI04)
C28697	Baculoviral_IAP_Repeat-Containing_Protein-6	IAP_Family_Protein	Baculoviral IAP Repeat-Containing Protein 6|Apollon|BIRC6|KIAA1289	Baculoviral IAP Repeat-Containing Protein 6, encoded by the BIRC6 gene, is a member of the IAP (inhibitors of apoptosis proteins) family and the ubiquitin-conjugating enzyme family. This protein is expressed as a 530-kD protein in gliomas and ovarian cancers. BIRC6 may protect cancer cells from undergoing apoptosis and resist to apoptosis in the presence of anticancer drugs. BIRC6 contains a 70-amino acid cysteine- and histidine-rich baculovirus IAP repeat (BIR) and a zinc-binding RING finger.
C28698	Laniquidar	Multidrug_Resistance_Modulator	Laniquidar|R101933	A stereoisomer of verapamil and third-generation P-glycoprotein inhibitor. Laniquidar inhibits the drug efflux pump P-glycoprotein, resulting in higher concentrations of antineoplastic agents in tumor cells that are multi-drug resistant due to the overexpression of P-glycoprotein. (NCI04)
C28699	Therapeutic_Tumor_Infiltrating_Lymphocytes	Miscellaneous_Biologic_Response_Modifier	Therapeutic Tumor Infiltrating Lymphocytes|Tumor Infiltrating Lymphocytes	A preparation of cells, consisting of autologous tumor infiltrating lymphocytes, that are manipulated in vitro and, upon administration in vivo, re-infiltrate the tumor to initiate tumor cell lysis. In vitro, therapeutic tumor-infiltrating lymphocytes (TILs) are isolated from tumor tissue and cultured with lymphokines such as interleukin-2; the therapeutic TILs are then infused into the patient, where, after re-infiltration of the tumor, they may induce lysis of tumor cells and tumor regression.  The use of therapeutic TILs is considered a form of adoptive immunotherapy.
C28700	_5q23-q32	Chromosome_Band	5q23-q32	A chromosome band present on 5q
C28701	TFIIA-Alpha-Beta-Like_Factor	Transcription_Factor	TFIIA-Alpha/Beta-Like Factor|ALF|GTF2A1-Like Factor|General Transcription Factor II A 1-Like Factor|TFIIA Large Subunit Isoform ALF|TFIIA-Alpha and Beta Like Factor	Encoded by human ALF Gene, 69-kD TFIIA-Alpha/Beta-Like Factor is a testis-specific general transcription factor with conserved regions I and IV and acidic region III, but a distinct region II. With GTF2A2 and TBP, ALF binds DNA and allows mRNA transcription initiation. ALF may be functionally identical with GTF2A1. (NCI)
C28702	_19q13_13	Chromosome_Band	19q13.13	A chromosome band present on 19q
C28703	Activator_of_S_Phase_Kinase_retired	Retired_Concepts	Activator of S Phase Kinase|ASK|DBF4 Homolog|Dumbbell Former 4 Homolog	Encoded by growth factor and E2F-regulated widely expressed human ASK Gene, 77-kD nuclear Activator of S Phase Kinase (dup) is a cyclin-like regulatory subunit of CDC7L1 kinase involved in G1/S transition. ASK mRNA and protein are low in G1, peak in S phase, and reduce in G2/M; ASK is extensively phosphorylated during S phase. Containing a bipartite NLS, conserved motifs N (N-terminus) and C (central region), and 2 PEST sequences, ASK appears essential for entry into S phase. Motif C is essential for CDC7L1 catalytic subunit interaction with ASK, a major activator of CDC7L1 kinase activity on MCM2.  (NCI)
C28704	_9p12	Chromosome_Band	9p12	A chromosome band present on 9p
C28705	TAF3B2	Basal_Transcription_Factor	TAF3B2|B-Related Factor 1|BRF|BRF1|BRF1 Homolog|BRF1 Homolog Subunit of RNA Polymerase III Transcription Initiation Factor IIIB|BRF1, S. cerevisiae, Homolog of|BRF1: BRF1 Homolog, Subunit of RNA Polymerase III Transcription Initiation Factor IIIB (S.cerevisiae)|GTF3B|GTF3B 90-kD Subunit|GTF3B, 90-kD Subunit|General Transcription Factor 3B 90-kD Subunit|General Transcription Factor 3B, 90-kD Subunit|General Transcription Factor IIIB 90kD Subunit|TAF3C|TAFIII90|TATA Box Binding Protein (TBP)-Associated Factor 3C|TATA Box Binding Protein (TBP)-Associated Factor RNA Polymerase III Subunit 2|TATA Box-Binding Protein-Associated Factor RNA Polymerase III Subunit 2|TATA Box-Binding Protein-Associated Factor, RNA Polymerase III, Subunit 2|TBP-Associated Factor RNA Polymerase III 90kD|TBP-Associated Factor, RNA Polymerase III, 90-kD|TF3B90|TFIIIB90|Transcription Factor IIIB 90-kD Subunit|Transcription Factor IIIB, 90-kD Subunit|Transcription Initiation Factor IIIB|hBRF	Encoded by human BRF1 Gene (TFIIB Family), alternative isoforms 1 (677-aa, 74-kD), 2 (134-aa, altered N- and C-termini), 3 (473-aa, shorter N-terminus), and 4 (242-aa) of General Transcription Factor 3B 90-kD Subunit function at different promoters on tRNA, 5S rRNA, and other small RNA genes. Related to GTF2B (N-terminus), GTF3B contains a highly charged region and HMG2-related region. Essential for transcription initiation, GTF3B (C-terminus) binds TBP (collectively, TFIIIB) as one of three RNA polymerase III transcription factor subunits. Following GTF3A or GTF3C recognition of promoter elements, GTF3B and RNA polymerase III bind sequentially. (NCI)
C28706	BCL7A_Protein	Protein_with_Unknown_or_Unclassified_Function	BCL7A Protein|B-Cell CLL Protein|BCL7A|Lymphoma 7A Protein	Encoded by widely expressed human BCL7A Gene, 231-aa 25-kD serine-rich BCL7A Protein has 90% sequence identity (N-terminal 51-aa) with BCL7B and BCL7C; possible members of an evolutionarily conserved family. BCL7A exhibits no recognizable motifs but shows homology with actin-binding Caldesmon. Recurrent three-way translocations of BCL7A with MYC and IGH occur in a high-grade B cell non-Hodgkin (Burkitt) lymphoma; the N-terminal BCL7A region is disrupted. (NCI)
C28707	B-Cell_Lymphoma-9_Protein	Signaling_Protein	B-Cell Lymphoma 9 Protein|B-Cell CLL Protein|BCL-9|Legless Homolog Protein|Lymphoma 9 Protein	Expressed in thymus, prostate, testis, ovary, small intestine, spleen, colon, and blood, 85-kb human BCL9 Gene at 1q21 encodes 1426-aa 150-kD nuclear B-Cell Lymphoma 9 Protein, containing an HD1 domain that interacts with the conserved PHD finger of PYGO1 and PYGO2. BCL9 (Lgs homolog, Drosophila) also binds to beta-Catenin, involved in WNT signal transduction pathway control of many fundamental developmental processes. BCL9 recruitment of PYGO to beta-Catenin may permit association with DNA-binding TCF to transcriptionally activate WNT target genes. BCL9 translocation that leaves the coding region intact is associated with B-cell acute lymphoblastic leukemia.  (NCI)
C28708	Orthologous_Gene	Gene	Orthologous Gene|Ortholog	A gene from one species which corresponds to a gene in another species that is related via a common ancestral species (a homologous gene), but which has evolved to become different from the gene of the other species. (http://biotech.icmb.utexas.edu)
C28709	Homologous_Gene	Gene	Homologous Gene|Gene Homolog|Homolog|Homologous Association|Homologue	A gene from one species which corresponds to a gene in another species and that is related via a common ancestral species.  These genes retain a similar sequence and function. (from http://biotech.icmb.utexas.edu)
C28710	RNA_Polymerase-III_Transcription_Initiation_Factor-BRF2	Basal_Transcription_Factor	RNA Polymerase III Transcription Initiation Factor BRF2|BRF2 Subunit of RNA Polymerase III Transcription Initiation Factor|BRF2, Subunit of RNA Polymerase III Transcription Initiation Factor, BRF1-Like|BRFU|FLJ11052|TFIIIB50|Transcription Factor IIB-Related Factor	RNA Polymerase III Transcription Initiation Factor BRF2, encoded by the BRF2 gene, is a 50-kD protein that is a subunit of RNA polymerase III transcription initiation factor. BRF2 is involved in the nucleation of a polymerase III-specific small nuclear RNA (snRNA) transcription initiation complex. BRF2 does not directly bind DNA but it interacts with the TATA-binding protein (TBP), and they then bind cooperatively to the polymerase III promoter region of snRNA. The BRF2 protein has a zinc ribbon domain and a core domain. The TBP/BRF2 complex does not have strict requirements for sequence motifs outside the TATA box. Arg235 and phe250 of TBP, and repeat 2 of the BRF2 core domain, are necessary for complex formation with DNA. BRF2 also forms a stable complex on the TATA box of the polymerase II-specific adenovirus major late promoter. (from OMIM 607013, LocusLink 55290, and NCI)
C28711	Transcription_Factor-Like_Nuclear_Regulator	Transcription_Factor	Transcription Factor-Like Nuclear Regulator|B-Double Prime 1 Subunit of RNA Polymerase III Transcription Initiation Factor IIIB|BDP1|HSA238520|KIAA1241|KIAA1689|Putative Transcription Factor-Like Nuclear Regulator|Putative Transcription Regulation Nuclear Protein|RNA Polymerase III GTF3B Subunit 1|TAF3B1|TATA Box Binding Protein (TBP)-Associated Factor|TFC5|TFIIIB150|TFIIIB90|TFNR|hB-Double Prime	Encoded by widely expressed human BDP1 Gene, 2254-aa 253-kD highly hydrophilic Transcription Factor-Like Nuclear Regulator contains several potential phosphorylation sites, two bipartite NLS, a DNA-ligase A1 ATP-dependent binding site, a MYB-like domain, and 9 copies of a 55-amino acid motif. Similar to yeast TFC5 and required for RNA polymerase III transcription, BDP1 binds promoter regions, suggesting that it is part of the initiation complex. (NCI)
C28712	Xq26-q28	Chromosome_Band	Xq26-q28	A chromosome band present on Xq
C28713	General_Transcription_Factor_3B_90-kD_Subunit	Retired_Concepts	General Transcription Factor 3B 90-kD Subunit|B-Related Factor 1|BRF|BRF1|BRF1 Homolog|BRF1 Homolog Subunit of RNA Polymerase III Transcription Initiation Factor IIIB|GTF3B|GTF3B 90-kD Subunit|General Transcription Factor IIIB 90kD Subunit|TAF3B2|TAF3C|TAFIII90|TATA Box Binding Protein (TBP)-Associated Factor 3C|TATA Box Binding Protein (TBP)-Associated Factor RNA Polymerase III Subunit 2|TATA Box-Binding Protein-Associated Factor RNA Polymerase III Subunit 2|TBP-Associated Factor RNA Polymerase III 90kD|TF3B90|TFIIIB90|Transcription Factor IIIB 90-kD Subunit|Transcription Initiation Factor IIIB|hBRF	Encoded by human BRF1 Gene (TFIIB Family), alternative isoforms 1 (677-aa, 74-kD), 2 (134-aa, altered N- and C-termini), 3 (473-aa, shorter N-terminus), and 4 (242-aa) of General Transcription Factor 3B 90-kD Subunit function at different promoters on tRNA, 5S rRNA, and other small RNA genes. Related to GTF2B (N-terminus), GTF3B contains a highly charged region and HMG2-related region. Essential for transcription initiation, GTF3B (C-terminus) binds TBP (collectively, TFIIIB) as one of three RNA polymerase III transcription factor subunits. Following GTF3A or GTF3C recognition of promoter elements, GTF3B and RNA polymerase III bind sequentially. (NCI)
C28714	Activin-A_Type-B_Receptor	Receptor_Serine-Threonine_Kinase	Activin A Type IB Receptor|ACTR-IB|ALK-4|Activin A Receptor, Type II-Like Kinase 4|Activin Receptor-Like Kinase 4|SKR2|Serine/Threonine-Protein Kinase Receptor R2	Expressed in kidney, pancreas, brain, lung, and liver and encoded by human ACVR1B Gene (TGFBR Family), 505-aa 57-kD Activin A Type IB Receptor (isoforms A, B, and C) is a type I membrane protein with intracellular Ser/Thr kinase domain. Isoform A contains a complete kinase domain; B and C have truncated kinase domains and distinct C-termini. Activins signal through a transmembrane heteromeric complex of type I and type II receptors that all contain a ligand-binding extracellular domain with a cysteine-rich region. Type I receptors are essential for signaling and type II receptors are required for binding ligand. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. (NCI)
C28715	Aryl_Hydrocarbon_Receptor_Nuclear_Translocator-2	Protein_Complex_Subunit	Aryl Hydrocarbon Receptor Nuclear Translocator 2|ARNT Protein 2|ARNT2|Aryl-Hydrocarbon Receptor Nuclear Translocator 2|KIAA0307	Aryl Hydrocarbon Receptor Nuclear Translocator 2, encoded by the ARNT2 gene, is a member of a novel transcription factor family consisting of a conserved basic helix-loop-helix (bHLH) structural motif contiguous with a PAS domain. (From LocusLink)
C28716	Brain-Specific_Angiogenesis_Inhibitor-2	Regulatory_Protein	Brain-Specific Angiogenesis Inhibitor 2|BAI2	Encoded by human BAI2 Gene (GPCR2 Family), similar to BAI1, and expressed in brain, heart, thymus, and skeletal muscle, 1572-aa 171-kD (precursor) Brain-Specific Angiogenesis Inhibitor 2, a seven-span transmembrane protein containing a GPS and 4 TSP-1 domains, may play a role in angiogenesis. (NCI)
C28717	Brain-Specific_Angiogenesis_Inhibitor-3	Regulatory_Protein	Brain-Specific Angiogenesis Inhibitor 3|BAI3	Encoded by human BAI3 Gene (GPCR2 Family), similar to BAI1, and expressed in brain and heart, 1522-aa 171-kD (precursor) Brain-Specific Angiogenesis Inhibitor 3, a seven-span transmembrane protein containing a CUB domain, a GPS domain, and 4 TSP-1 domains, may play a role in angiogenesis. (NCI)
C28718	BAI1-Associated_Protein-1	Signaling_Protein	BAI1-Associated Protein 1|BAIAP1	Encoded by human BAIAP1 Gene (MAGUK Family), 1256-aa 137-kD BAI1-Associated Protein 1 contains 2 WW domains, a guanylate kinase domain, and 6 PDZ/DHR domains BAIAP1 protein interacts with the cytoplasmic region of BAI1 and may play a role in cell adhesion and signal transduction. (NCI)
C28719	Anti-human_Chorionic_Gonadotropin_Vaccine	Antineoplastic_Vaccine	Anti-human Chorionic Gonadotropin Vaccine
C28720	Bridging_Integrator-1_Protein	Adaptor_Signaling_Protein	Bridging Integrator 1|Amphiphysin II|Amphiphysin-Like Box Dependant MYC Interacting Protein 1|Amphiphysin-Like Protein|BIN1|Box-Dependent MYC-Interacting Protein-1|MYC Box Dependent Interacting Protein 1	Encoded as ten alternate splicing variant isoforms by human BIN1 Gene, ubiquitously expressed nucleocytoplasmic adaptor protein Bridging Integrator 1 exhibits differential binding to dynamin, synaptojanin (via sh3 domain), alpha-adaptin, endophilin, clathrin, and MYC protein. BIN1 interacts with the MYC N-transactivation domain in a manner requiring the conserved MYC box regions 1 and 2. Some isoforms may play a role in protein targeting during synaptic vesicle endocytosis. BIN1 contains a BAR domain and an SH3 domain and may be phosphorylated by protein kinase C. (NCI)
C28721	Recombinant_KSA_Glycoprotein	Tumor_Antigen	Recombinant KSA Glycoprotein|CO17-1A|EGP|Ep-CAM|GA733|KSA Glycoprotein	Recombinant KSA Glycoprotein is a therapeutic counterpart of tumor-associated KSA antigen, a type-I transmembrane glycoprotein cellular adhesion molecule with a molecular mass of 40 kDa, overexpressed on the majority of tumor cells of most human epithelia of variety of tumor tissues such as stomach, colon, pancreas, gall bladder, bile duct, mammary gland, breast and lung carcinoma. It has been suggested to be involved in the differentiation, growth and organization of epithelial cells within tissues under normal physiological conditions. The antigen has been used as a target for diagnosis and for passive and active immunotherapy of colorectal cancer. Immunization with KSA Glycoprotein elicits both humoral and Th1-associated cellular immune responses.(NCI)
C28724	MART-1_Antigen	Vaccine_Antigen	MART-1 Antigen|Antigen LB39-AA|Antigen SK29-AA|MART-1|MART-1 Tumor Antigen|MART1|MLANA|MLANA Protein|Melan A|Melan-A|Melan-A Protein|Melanoma Antigen Recognized by T-Cells 1	A tumor-associated melanocytic differentiation antigen. Vaccination with MART-1 antigen may stimulate a host cytotoxic T-cell response against tumor cells expressing the melanocytic differentiation antigen, resulting in tumor cell lysis. (NCI04)
C28725	Therapeutic_Tyrosinase-Related_Protein-1	Tumor_Antigen	Recombinant Tyrosinase-Related Protein-1|TRP-1|Tyrosinase-Related Protein-1	A tumor-associated antigen used in vaccine therapy to elicit antibody and T-cell response.(NCI)
C28726	Small_Inducible_Cytokine-A13	Beta_Chemokine	Small Inducible Cytokine A13|CCL13|CK-Beta-10|Chemokine (C-C Motif) Ligand 13|MCP-4|Monocyte Chemoattractant Protein 4|Monocyte Chemotactic Protein 4|NCC-1|New CC Chemokine 1|Small Inducible Cytokine Subfamily A (Cys-Cys), Member 13	Induced by IL-1 and TNF-alpha, widely expressed, and encoded by human CCL13 Gene (Intercrine Beta Family), 98-aa 11-kD (precursor) Small Inducible Cytokine A13 is a secreted chemotactic factor for monocytes, lymphocytes, basophils, and eosinophils that signals through CCR2B and CCR3 receptors and is involved in immunoregulatory and inflammatory processes. The protein can bind heparin and isoforms MCP-4, (LA)MCP-4, and (FNPQGLA)MCP-4 exist. CCL13 may be involved in atherosclerosis. (NCI)
C28727	Small_Inducible_Cytokine-A14	Beta_Chemokine	Small Inducible Cytokine A14|CCL14|Chemokine (C-C Motif) Ligand 14|Chemokine CC-1|Chemokine CC-1/CC-3|Chemokine CC-3|HCC-1/HCC-3|NCC-2|Small Inducible Cytokine Subfamily A (Cys-Cys), Member 14	Constitutively expressed in several tissues by human CCL14 Gene (Intercrine Beta Family), secreted 93-aa 11-kD (precursor) Small Inducible Cytokine A14 acts via MIP-1 alpha receptors to induce intracellular calcium changes and enzyme release in monocytes and to enhance CD34 myeloid progenitor cell proliferation. (NCI)
C28728	Small_Inducible_Cytokine-A3-Like-1_Protein	Beta_Chemokine	Small Inducible Cytokine A3-Like 1|464.2|CCL3L1|Chemokine (C-C Motif) Ligand 3-Like 1|Chemokine, CC Motif, Ligand 3-Like Protein 1|G0/G1 Switch Regulatory Protein 19-2|G0S19-2|LD78|LD78BETA|PAT 464.2|SCYA3L|SCYA3L1|Tonsillar Lymphocyte LD78 Beta Protein	Chemokine (C-C Motif) Ligand 3-Like 1, encoded by the CCL3L1 gene, belongs to an intercrine beta family. This signaling cytokine attracts and activates leukocytes, and has an anti-HIV-1 activity. It is implicated in cell cycle and signal transduction. (from http://www.dsi.univ-paris5.fr/genatlas/fiche.php?n=2076)
C28729	Small_Inducible_Cytokine-A15	Beta_Chemokine	Small Inducible Cytokine A15|CCL15|Chemokine (C-C Motif) Ligand 15|Chemokine CC-2|HCC-2|LKN-1|Leukotactin-1|MIP-1 Delta|MIP-5|MRP-2B|Macrophage Inflammatory Protein 5|NCC-3	Widely expressed by human CCL15 Gene (Intercrine Beta Family), secreted 113-aa 12-kDa (precursor) Small Inducible Cytokine A15 is a chemotactic factor for T cells and monocytes that acts mainly via CCR1, induces intracellular calcium changes in monocytes, and induces N-acetyl-beta-D-glucosaminidase release in monocytes. CCL15 also binds to CCR3. (NCI)
C28730	Small_Inducible_Cytokine-A17	Beta_Chemokine	Small Inducible Cytokine A17|CC Chemokine TARC|CCL17|Chemokine (C-C Motif) Ligand 17|Small Inducible Cytokine Subfamily A (Cys-Cys), Member 17|T Cell-Directed CC Chemokine|Thymus and Activation-Regulated Chemokine	Expressed by human CCL17 Gene (Intercrine Beta Family) in thymus, lung, colon, and small intestine and induced by PHA in mononuclear cells and by cytokines in monocytes, secreted 94-aa 10-kD (precursor) Small Inducible Cytokine A17 is an immunoregulatory chemotactic factor for T lymphocytes that binds to CCR4 and CCR8 receptors and is important in inflammatory processes, in thymic T cell development, and in trafficking and activation of mature T cells. (NCI)
C28731	Small_Inducible_Cytokine-A7	Beta_Chemokine	Small Inducible Cytokine A7|CCL7|FIC|MARC|MCP-3|MCP3|Monocyte Chemoattractant Protein 3|Monocyte Chemotactic Protein 3|NC28|SCYA7	Small Inducible Cytokine A7, encoded by the CCL7 gene, is a secreted chemokine which attracts macrophages during inflammation and metastasis. It is a member of the C-C subfamily of chemokines which are characterized by having two adjacent cysteine residues. The protein is an in vivo substrate of matrix metalloproteinase 2, an enzyme which degrades components of the extracellular matrix. (from LocusLink)
C28732	Small_Inducible_Cytokine-A18	Beta_Chemokine	Small Inducible Cytokine A18|AMAC-1|Alternative Macrophage Activation-Associated CC Chemokine 1|CC Chemokine PARC|CCL18|Chemokine (C-C Motif) Ligand 18|Chemokine (C-C Motif) Ligand 18 (Pulmonary and Activation-Regulated)|DC-CK1|Dendritic Cell Chemokine 1|MIP-4|Macrophage Inflammatory Protein 4|Pulmonary and Activation-Regulated Chemokine|Small Inducible Cytokine Subfamily A (Cys-Cys), Member 18|T Cell-Directed CC Chemokine|Thymus and Activation-Regulated Chemokine	Induced by glucocorticoids, PMA, IL-4, IL-13, and IL-10 and expressed by human CCL18 Gene (Intercrine Beta Family) in lung, lymph nodes, placenta, bone marrow, dendritic cells, and macrophages, secreted 89-aa 10-kDa (precursor) Small Inducible Cytokine A18, an immunoregulatory chemotactic cytokine for naive T cells, CD4+ and CD8+ T cells, and nonactivated lymphocytes involved in inflammatory processes s well as humoral and cell-mediated immunity. CCL18 may be involved in B cell migration into lymph node follicles. (NCI)
C28733	Small_Inducible_Cytokine-A19	Beta_Chemokine	Small Inducible Cytokine A19|Beta Chemokine Exodus-3|CC Chemokine Ligand 19|CCL19|CK Beta-11|Chemokine (C-C Motif) Ligand 19|EBI1-Ligand Chemokine|ELC|Exodus-3|MIP-3-Beta|Macrophage Inflammatory Protein 3 Beta|Small Inducible Cytokine Subfamily A (Cys-Cys), Member 19	Expressed in lymph nodes, thymus, appendix, colon, trachea, spleen, small intestine, lung, kidney, and stomach by human CCL19 Gene (Intercrine Beta Family), secreted immunoregulatory 98-aa 11-kD (precursor) Small Inducible Cytokine A19 is involved in inflammatory and immunological responses, binds to CCR7 receptor, and plays a role in thymic T cell trafficking and T and B cell migration. (NCI)
C28734	Small_Inducible_Cytokine-A20	Beta_Chemokine	Small Inducible Cytokine A20|Beta Chemokine Exodus-1|CC Chemokine LARC|CCL20|Chemokine (C-C Motif) Ligand 20|Exodus-1|Liver and Activation-Regulated Chemokine|MIP-3-Alpha|Macrophage Inflammatory Protein 3 Alpha|Small Inducible Cytokine Subfamily A (Cys-Cys), Member 20	Repressed by IL-10 and induced by LPS, PMA, TNF, and INF Gamma in liver, lymph nodes, appendix, PBL, thymus, prostate, testis, small intestine, colon, and fetal lung, the human CCL20 Gene product (Intercrine Beta Family), Small Inducible Cytokine A20, is a secreted chemotactic factor for lymphocytes, neutrophils, and dendritic cells that binds CCR6 and may inhibit proliferation of myeloid progenitors. (NCI)
C28735	Small_Inducible_Cytokine-A22	Beta_Chemokine	Small Inducible Cytokine A22|CC Chemokine STCP-1|CCL22|Chemokine (C-C Motif) Ligand 22|Macrophage-Derived Chemokine|Small Inducible Cytokine Subfamily A (Cys-Cys), Member 22|Stimulated T Cell Chemotactic Protein 1	Expressed in macrophage, monocyte-derived dendritic cells, thymus, lymph node, appendix, activated monocytes, resting and activated macrophages, lung, small intestine, and spleen by human CCL22 Gene (Intercrine Beta Family), secreted immunoregulatory 93-aa 11-kD (precursor) Small Inducible Cytokine A22 is a chemotactic factor for monocytes, dendritic cells, natural killer cells, and activated T lymphocytes that binds to receptor CCR4 and may play a role in activated/effector T lymphocyte trafficking to inflammatory sites. (NCI)
C28736	Small_Inducible_Cytokine-A24	Beta_Chemokine	Small Inducible Cytokine A24|CCL24|CK-Beta-6|Eotaxin-2|MPIF-2|Myeloid Progenitor Inhibitory Factor-2|Small Inducible Cytokine Subfamily A (Cys-Cys), Member 24	Expressed in activated monocytes and activated T lymphocytes by human CCL24 Gene (Intercrine Beta Family), N-glycosylated secreted immunoregulatory Small Inducible Cytokine A24 binds to CCR3, exerts chemotactic activity on resting T lymphocytes, neutrophils, and eosinophils in inflammatory processes, and exhibits strong suppression of hematopoietic progenitor colony formation. (NCI)
C28737	Small_Inducible_Cytokine-A25	Beta_Chemokine	Small Inducible Cytokine A25|CCL25|Chemokine (C-C Motif) Ligand 25|Chemokine TECK|Ck Beta-15|Small Inducible Cytokine Subfamily A (Cys-Cys), Member 25|TECKvar|Thymus Expressed Chemokine	Expressed in thymic and intestinal dendritic cells by CCL25 Gene (Intercrine Beta Family), secreted immunoregulatory 150-aa 17-kD (precursor) Small Inducible Cytokine A25 is a CCR9 receptor agonist and chemotactic for thymocytes, activated macrophages, THP-1 cells, and dendritics cells in inflammatory processes. Two alternatively spliced gene variants encode antagonist isoforms. (NCI)
C28738	Small_Inducible_Cytokine-A23_Isoform-CKBeta8	Beta_Chemokine	Small Inducible Cytokine A23 Isoform Ckbeta8|C6 Beta-Chemokine|CCL23|CK-Beta-8|CKB-8|Chemokine (C-C Motif) Ligand 23|HMRP-2A|MIP-3|MPIF-1|Macrophage Inflammatory Protein 3|Myeloid Progenitor Inhibitory Factor-1|Small Inducible Cytokine A23 Isoform Ckbeta8-1|Small Inducible Cytokine Subfamily A (Cys-Cys), Member 23	Expressed in lung, liver, skeletal muscle, bone marrow, placenta, pancreas, and fetal liver by human CCL23 Gene (Intercrine Beta Family), secreted immunoregulatory Small Inducible Cytokine A23 Isoform Ckbeta8 is a potent CCR1 receptor agonist and suppressor of progenitor cell colony formation with chemotactic activity for resting T lymphocytes, monocytes, and neutrophils in inflammatory processes.  (NCI)
C28739	Small_Inducible_Cytokine-A26	Beta_Chemokine	Small Inducible Cytokine A26|CC Chemokine IMAC|CCL26|Chemokine (C-C Motif) Ligand 26|Eotaxin-3|MIP-4-Alpha|Macrophage Inflammatory Protein 4-Alpha|Small Inducible Cytokine Subfamily A (Cys-Cys), Member 26|TSC-1|Thymic Stroma Chemokine-1	Ubiquitously expressed by human CCL26 Gene (Intercrine Beta Family), secreted monomeric immunoregulatory 94-aa 11-kD (precursor) Small Inducible Cytokine A26 is an activator of receptor CCR3 and chemotactic for eosinophils and basophils in inflammatory processes. CCL26 may contribute to eosinophil accumulation in atopic diseases. (NCI)
C28740	Small_Inducible_Cytokine-A27	Beta_Chemokine	Small Inducible Cytokine A27|CC Chemokine ILC|CCL27|CTACK|Chemokine (C-C Motif) Ligand 27|Cuteaneous T-Cell Attracting Chemokine|Eskine|IL-11R Alpha-Locus Chemokine|Skinkine|Small Inducible Cytokine Subfamily A (Cys-Cys), Member 27	Expressed in testis, thymus, placenta, ovary, and skin by human CCL27 Gene (Intercrine Beta Family), immunoregulatory 112-aa 12.6-kD (precursor) Small Inducible Cytokine A27 is a chemotactic factor that binds to CCR10 and mediates homing of memory T lymphocytes to cutaneous sites in inflammatory processes. (NCI)
C28741	Ideal	General_Modifier	Ideal	Conforming to an ultimate standard of perfection or excellence.
C28742	Body_Weight	Retired_Concepts	Body Weight	The measure of the weight of a person's body in standard units, such as pound or kilogram. (NCI)
C28743	Punch_Biopsy	Biopsy	Punch Biopsy|Trephine Biopsy	A biopsy performed using a punch, an instrument for cutting and removing a disk of tissue. (from medterms.com)
C28744	Tracheobronchial	Anatomy_Modifier	Tracheobronchial	Pertaining both to the tracheal and bronchial tubes, or to their junction.
C28745	Subsegmental_Lymph_Node	Lymph_Node_by_Anatomic_Site	Subsegmental Lymph Node|Subsegmental Lymph Node Station	The lymph nodes around the subsegmental bronchi.
C28746	Enhancing_Lesion	Radiologic_Finding	Enhancing Lesion|Contrast-Enhancing Lesion|Gadolinium-Enhancing Lesion|Gd-Enhancing Lesion	An enhancing lesion is a well-demarcated area of unequivocally increased signal intensity on T1-weighted spin-echo (SE) images compared with normal-appearing, surrounding tissue following intravenous injection of a gadolinium chelate. (from http://cni.bwh.harvard.edu/projects/gdc/gdc_MRcriteria.html)
C28747	Reader	Person	Reader	The specific medical individual, usually a radiologist, who looks at and interprets a medical image.
C28748	C-X-C_Motif_Chemokine_Receptor-6	Chemokine_Receptor	Chemokine (C-X-C Motif) Receptor 6|BONZO|CXC Chemokine Receptor Type 6|CXC-R6|CXCR-6|G Protein-Coupled Receptor Bonzo|G Protein-Coupled Receptor STRL33|G Protein-Coupled Receptor TYMSTR|STRL33|TYMSTR	Expressed in spleen, thymus, small intestine, activated T cells, peripheral blood leukocytes, prostate, colon, and placenta by human CXCR6 Gene (GPCR1 Family), 342-aa 39-kD integral membrane protein Chemokine (C-X-C Motif) Receptor 6 (CXCL16 ligand) appears to function in interactions between dendritic cells and T cells, in regulating T-cell migration, and in trafficking of effector T cells mediating type-1 inflammation. CXCR6 is a coreceptor for some strains of HIV. (from NCI)
C28749	Spiculate	Disease_Modifier	Spiculate|Spiculation	Covered with or having small needlelike structures (spicules) or fine fleshy points.
C28750	Cytochrome-P450-2C9	Cytochrome-P450	Cytochrome P450 2C9|CYP2C9|CYPIIC9|Cytochrome P450, Family 2, Subfamily C, Polypeptide 9|Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 10|Cytochrome P450, Subfamily IIC (Mephenytoin 4-Hydroxylase), Polypeptide 9|EC 1.14.14.1|Flavoprotein-Linked Monooxygenase|Mephenytoin 4-Hydroxylase|Microsomal Monooxygenase|P-450MP|P450 MP-4|P450 PB-1|S-Mephenytoin 4-Hydroxylase|Xenobiotic Monooxygenase	Induced by rifampin and expressed in liver by polymorphic human CYP2C9 Gene (CYP450 Family), 490-aa 56-kD Cytochrome P450 2C9 localizes to the endoplasmic reticulum membrane and oxidizes steroids, fatty acids, and xenobiotics in drug metabolism and in the synthesis of cholesterol, steroids and other lipids.  (NCI)
C28751	Phosphatidylcholine_Biosynthesis	Biosynthesis	Phosphatidylcholine Biosynthesis	The major pathway for the biosynthesis of phosphatidylcholine occurs via the CDP-choline pathway. Choline kinase is the initial enzyme that produces phosphocholine from choline in the sequence and may play a regulatory role. (From LocusLink and NCI)
C28752	Chromosome_Cohesion	Cell_Division_Process	Chromosome Cohesion	The faithful segregation of genetic information requires highly orchestrated changes of chromosome structure during the mitotic cell cycle. The linkage between duplicated sister DNAs is established during S phase and maintained throughout G2 phase (cohesion). In early mitosis, dramatic structural changes occur to produce metaphase chromosomes, each consisting of a pair of compacted sister chromatids (condensation). At anaphase onset, a signal is produced to disrupt the linkage between sister chromatids (separation), allowing them to be pulled apart to opposite poles of the cell. (from PubMed 10966455)
C28753	_10p12_1	Chromosome_Band	10p12.1	A chromosome band present on 10p
C28754	Innate_Bone_Remodeling	Bone_Remodeling	Innate Bone Remodeling|Biological Bone Remodeling|Normal Bone Remodeling	Innate Bone Remodeling takes place in the adult skeleton at discrete foci. The continuous turnover of bone matrix and mineral that involves first, an increase in bone resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). This process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.
C28755	Unclassified_Drugs_and_Chemicals	Drugs_and_Chemicals	Unclassified Drugs and Chemicals
C28756	Small_Inducible_Cytokine-B10	Alpha_Chemokine	Small Inducible Cytokine B10|CXCL10|Chemokine (C-X-C Motif) Ligand 10|Gamma IP10|IFN-Gamma-Inducible Protein-10|IP-10|Interferon-Gamma Induced Protein|Interferon-Inducible Cytokine IP-10|Interferon-alpha Inducible Protein 10|NEX348|Protein 10 from Interferon (Gamma)-Induced Cell Line|Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 10	A member of the alpha-chemokine family, IP10 is secreted from macrophages, endothelial cells, and keratinocytes in response to IFN-gamma and activates a G protein coupled receptor.  IP10 has homology to PFIV, BTG, CTAP-III, and peptides associated with cell proliferation, is a potent inhibitor of angiogenesis, inhibits bone marrow colony formation, has anti-tumor activity, is a chemoattractant for monocytes and T-cells, promotes T-cell adhesion to endothelial cells, and probably participates in chronic cell-mediated inflammatory reactions.  The IP10 gene is a RAS signaling target.  (from OMIM 147310 and NCI)
C28757	Small_Inducible_Cytokine-B11	Alpha_Chemokine	Small Inducible Cytokine B11|Beta-R1|CXCL11|Chemokine (C-X-C Motif) Ligand 11|H174|I-TAC|IP-9|Interferon-Gamma-Inducible Protein-9|Interferon-Inducible T-Cell Alpha Chemoattractant|Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 11|Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 9B	Encoded by INF gamma- and INF beta-induced human CXCL11 Gene (Intercrine Alpha/Chemokine CXC Family) in leukocytes, pancreas, liver, astrocytes, thymus, spleen, lung, placenta, prostate, small intestine, and keratinocytes, secreted 94-aa 10-kD (precursor) Small Inducible Cytokine B11 is a chemotactic ligand for 7-transmembrane, G protein-coupled receptor CXCR3 that regulates activated T cell response. (NCI)
C28774	Stromal_Cell-Derived_Factor-1	Alpha_Chemokine	Stromal Cell-Derived Factor 1|CXCL12|Chemokine (C-X-C Motif) Ligand 12|PBSF|Pre-B Cell Growth Stimulating Factor|SDF-1|hIRH	Encoded by human CXCL12 Gene (Intercrine Alpha/Chemokine CXC Family), alternative alpha and beta isoforms of secreted 93-aa 11-kD (precursor) Stromal Cell-Derived Factor 1 are chemoattractant ligands for CXCR4 on T-lymphocytes and monocytes. The beta form contains additional C-terminal sequence. SDF1 is cleaved of an N-terminal tetrapeptide by MMP2 and loses CXCR4 affinity. Human and mouse protein sequences are nearly 92% identical. SDF1 induces intracellular actin polymerization in lymphocytes and may regulate immune surveillance and extravasation of lymphocytes and monocytes rather than in inflammation. With CD4, SDF1 is a coreceptor on CD4+ lymphocytes for HIV-1. (NCI)
C28775	_161-180_ESO-1	NY-ESO-1_Peptide_Vaccine	ESO-1 (161-180) Peptide Vaccine|(161-180)ESO-1	A recombinant 19-residue peptide vaccine consisting of amino acids 161 through 180 of the cancer/testis (CT) antigen. ESO-1 (161-180) peptide vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for ESO-1, resulting in decreased tumor growth. ESO-1 is expressed in a variety of cancers, including melanoma, breast, bladder, prostate, and hepatocellular cancers. (NCI04)
C28776	_H115D_VHL35	Von_Hippel-Lindau_Peptide_Vaccine	(H115D)VHL35	A peptide vaccine derived from the von Hippel-Lindau (VHL) tumor suppressor protein, a general transcription factor.  In (H115D)VHL35 peptide, histidine is substituted for an aspartic acid in position 115.  It might be used to elicit or boost cellular immunity to cancers that expressing the von Hippel-Lindau mutation. (NCI04)
C28777	_1_9-Nonanediol	Organic_Solvents	1,9-Nonanediol	An aliphatic alcohol (with nine carbon atoms and two hydroxyl groups at positions 1 and 9) used in chemical synthesis and biomedical research.  1,9-Nonanediol suppresses glycine currents in neurons; glycine is a major inhibitory neurotransmitter in the mature mammalian central nervous system. (NCI04)
C28778	_1-Aminocyclopentane	Retired_Concepts	1-Aminocyclopentane
C28780	_117-126_FGF-5_Peptide	Vaccine_Antigen	117-126:FGF-5 Peptide|Fibroblast Growth Factor-5 (117-126) Peptide	A fragment of fibroblast growth factor-5 (FGF-5). Originally isolated from a renal cell carcinoma cell line that overexpressed FGF-5, FGF-5:117-126 peptide is recognized by tumor infiltrating cytotoxic T lymphocytes. Overexpressed by several cancer cell types, this peptide is being tested as a potential target for antineoplastic immunotherapies. (NCI04)
C28781	_11D10_AluGel_Anti-Idiotype_Monoclonal_Antibody	Monoclonal_Antibody_11D10	11D10 AluGel Anti-Idiotype Monoclonal Antibody	A monoclonal anti-idiotype antibody adsorbed to aluminum hydroxide gel (AluGel) with potential antineoplastic activity.  11D10 AluGel anti-idiotype monoclonal antibody mimics the human milk fat globule (HMFG) antigen found in breast and other cancers.  Vaccination with 11D10 AluGel anti-idiotype monoclonal antibody may induce a host antibody response against tumor cells positive for the HMFG antigen. (NCI04)
C28784	_27-35_27L_MART-1	Vaccine_Antigen	27-35(27L):MART-1
C28786	_3H1_Aluminum_Hydroxide-Precipitated_Anti-Idiotype_Monoclonal_Antibody	Monoclonal_Antibody	3H1 Aluminum Hydroxide-Precipitated Anti-Idiotype Monoclonal Antibody	An aluminum hydroxide-precipitated recombinant monoclonal antibody in which the heavy and light chain variable domains mimic a specific epitope of the tumor-associated protein carcinoembryonic antigen (CEA). This agent may be used as a cancer vaccine against tumors that express CEA. (NCI04)
C28787	_5-HP	Retired_Concepts	5-HP
C28788	_8-Azaguanine	Purine_Antagonist	8-Azaguanine	A purine analogue with potential antineoplastic activity.  8-Azaguanine interferes with the modification of transfer ribonucleic acid (tRNA) by competing with guanine for incorporation into tRNA catalyzed by the enzyme tRNA-guanine ribosyltransferase (tRNA-guanine transglycosylase).  Altered guanine modification of tRNA has been implicated in cellular differentiation and neoplastic transformation.  8-Azaguanine also inhibits the formation of 43S and 80S initiation complexes, thereby interfering with initiation of translation and inhibiting protein synthesis.  This agent inhibits tumor cell growth and stimulates cell differentiation. (NCI04)
C28789	_9-Ethyl_6-Mercaptopurine	Purine_Antagonist	9-Ethyl 6-Mercaptopurine|9-Ethyl 6-MP	A synthetic alkyl derivative prodrug of the antineoplastic agent 6-mercaptopurine (6-MP).  In vivo, 9-ethyl 6-mercaptopurine appears to be converted to 6-MP, which substitutes for the normal nucleoside and fraudulently incorporates into DNA and inhibits de novo purine synthesis, thereby inducing cell death. (NCI04)
C28793	_9H-Purine-6Thio-98D	Purine_Antagonist	9H-Purine-6Thio-98D	An antimetabolite analogue of purine with antineoplastic and immuno-suppressant properties.  9H-Purine-6Thio-98D substitutes for the normal nucleoside and fraudulently incorporates into DNA and inhibits de novo purine synthesis, thereby inducing cell death. In vivo, this agent, also known as 6MP-arabinoside, may occur as a metabolite of the antineoplastic agent mercaptopurine. (NCI04)
C28794	A_and_D_Ointment	Topical_Preparation	A and D Ointment|A&D Ointment	A topical preparation containing fat-soluble vitamins A and D usually in a lanolin-petrolatum base, A and D Ointment promotes healing of minor burns, rashes, sunburn, skin irritations, and acne; and prevents diaper rash. Vitamin A is essential for diverse cellular functions, immune system functions, and maintenance of mucous membranes, while vitamin D regulates calcium and phosphorous metabolism. (NCI04)
C28795	Alpha-Thioguanine_Deoxyriboside	Purine_Antagonist	Alpha-Thioguanine Deoxyriboside|6H-Purine-6-thione, 2-amino-9-(2-deoxy-.alpha.-D-erythro-pentofuranosyl)-1,9-dihydro- (9CI)|9H-Purine-6-thiol, 2-amino-9-(2-deoxy-.alpha.-D-erythro-pentofuranosyl)-|A-TGDR|Thioguanine 9.alpha.D-2'-deoxyriboside|alpha.-2'-Deoxy-6-thioguanosine|alpha.-2'-Deoxythioguanosine|alpha.-Thiodeoxyguanosine	A purine analog with potential antineoplastic activity. (NCI04)
C28796	Acronycine	DNA_Adduct_Forming_Agent	Acronycine	A natural alkaloid with an acridine structure isolated from the bark of the plant Acronychia baueri (Australian scrub ash) with antineoplastic properties.  Acronycine appears to alkylate DNA and interfere with DNA replication. (NCI04)
C28797	ADA_Transduced_T-Cell	Biological_Agent	ADA Transduced T Cell	T cells harvested from a patient with adenosine deaminase (ADA) deficiency and transduced with a vector containing the gene for ADA. ADA catalyzes the hydrolysis of adenosine to inosine; ADA deficiency causes a form of severe combined immunodeficiency (SCID).  Following genetic modification, the T cells are returned to the patient, where they produce functional ADA.  ADA-transduced T cells have been shown to improve immune function in individuals with ADA deficiency. (NCI04)
C28798	Ametantrone_Acetate	Ametantrone	Ametantrone Acetate	Acetate salt of Ametantrone, a topoisomerase II inhibitor of the anthrapyrazole family that causes covalent cross-links in DNA.
C28800	Amino-Arginine	Nitric_Oxide_Synthetase_Inhibitor	Amino-Arginine	An amino acid derivative.  As an analog of arginine, amino-arginine competes with the normal substrate arginine and binds to the heme of the NOS as a false substrate, thereby inhibiting endothelial and inducible nitric oxide synthetases (eNOS / NOS III and iNOS / NOS II).  Arginine is the only physiological substrate for NOS which, in eukaryotic cells, generates NO and L-citrulline from L-arginine and molecular oxygen in a five-electron transfer reaction.  This clinical use of amino-arginine is limited due to its epileptogenic properties. (NCI04)
C28801	Amygdalin	Cyanoglycoside_Agent	Amygdalin|D, L, - amygdalin	A cyanogenic glucoside isolated from almonds and seeds of other plants of the family Rosaceae. Amygdalin is converted by plant emulsin (a combination of a glucosidase and a nitrilase) or hydrochloric acid into benzaldehyde, D-glucose, and hydrocyanic acid. (NCI04)
C28802	Aphidicoline_Glycinate	DNA_Polymerase_Inhibitor	Aphidicoline Glycinate	A tetracyclic diterpene antibiotic isolated from the fungus Cephalosporium aphidicola and other fungal species with potential antineoplastic activity.  Aphidicoline glycinate blocks the cell cycle at early S-phase by specifically inhibiting DNA polymerases in eukaryotic cells, induces apoptosis, and stops the growth of eukaryotic cells and certain viruses by selectively inhibiting DNA polymerase II or viral-induced DNA polymerases. (NCI04)
C28803	Azotomycin	Miscellaneous_Antineoplastic_Antibiotic	Azotomycin|A 10270B|Diazomycin B|Duazomycin B|L-Norleucine, 6-diazo-N-(6-diazo-N-L-.gamma.-glutamyl-5-oxo-L-norleucyl)-5-oxo- (8CI 9CI)	An antineoplastic-antibiotic diazo analog of L-glutamine isolated from the bacterium Streptomyces ambofaciens.  Azotomycin inhibits glutamine-dependent enzymes involved in purine and pyrimidine biosynthesis, resulting in inhibition of DNA synthesis. (NCI04)
C28804	Abacavir	Reverse_Transcriptase_Inhibitor	Abacavir Sulfate|1592U89|ABACAVIR SULFATE|Abacavir|Ziagen	A synthetic carbocyclic nucleoside analog.  In vivo, the activated triphosphate metabolite of abacavir is incorporated into the viral DNA instead of the natural substrate deoxyguanosine, thereby inhibiting human immunodeficiency virus (HIV) reverse transcriptase (RT) and, so, the replication of the viral DNA and infectious viral particles.  This agent decreases HIV viral loads, retards or prevents the damage to the immune system, and reduces the risk of developing AIDS. (NCI04)
C28805	Denatured_Absolute_Ethanol	Drug_Vehicle	Denatured Absolute Ethanol|Absolute Ethanol; Denatured
C28806	Acebutolol	Beta-Adrenergic_Blocking_Agent	Acebutolol Hydrochloride|ACEBUTOLOL HYDROCHLORIDE|Acebutolol	A synthetic butyranilide derivative, hypotensive and antiarrhythmic Acebutolol acts as a cardioselective beta-adrenergic antagonist with little effect on bronchial receptors and has intrinsic sympathomimetic properties. Having stabilizing and quinidine-like effects on cardiac rhythm, Acebutolol is used in ventricular arrhythmias. Other indications include hypertension, alone or in combinations with other agents. (NCI04)
C28807	Acetaminophen_3	Analgesic_Preparation	Acetaminophen #3|Acetaminophen with Codeine|Tylenol with Codeine	A synthetic p-aminophenol derivative combined with codeine, anti-inflammatory and analgesic Acetaminophen 3 is used against inflammatory conditions, fever, and pain. Codeine is an opium alkaloid with analgesic properties. The active principal metabolite of phenacetin, Acetaminophen appears to inhibit prostaglandin biosynthesis in the central nervous system and less in peripheral tissues. Equipotent to acetylsalicylic acid, but more toxic, Acetaminophen may cause liver and kidney damage, especially in children. (NCI04)
C28808	Acetaminophen_Diphenhydramine	Cough_and_Cold_Preparation	Acetaminophen/Diphenhydramine	A synthetic p-aminophenol derivative and diphenhydramine combination, anti-inflammatory, analgesic, and anti-allergic Acetaminophen Diphenhydramine is used to treat symptoms of allergies and hay fever. The active principal metabolite of phenacetin, Acetaminophen appears to inhibit prostaglandin biosynthesis in the central nervous system and less in peripheral tissues. Diphenhydramine blocks histamine effects, preventing sneezing and itchy, watery eyes, as well as nasal and other allergy and hay fever symptoms. (NCI04)
C28809	Acetazolamide	Carbonic_Anhydrase_Inhibitor	Acetazolamide|ACETAZOLAMIDE|Diacarb|Diamox|Diluran|N-(5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl)acetamide|N-[5-(Aminosulfonyl)-1,3,4-thiadiazol-2-yl]acetamide	An agent that inhibits the function of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions.  Distributed throughout many cells and tissues, carbonic anhydrases play important roles in mineral and metabolic homeostasis. (NCI04)
C28810	Ad_CMV_I_kappaB_alpha	Viral_Vector-Gene_Complex	Ad CMV I kappaB alpha|AdCMVIkappaBalpha
C28811	Adefovir	Reverse_Transcriptase_Inhibitor	Adefovir Dipivoxil|ADEFOVIR DIPIVOXIL|Adefovir|GS-0393|Hepsera|PMEA|Phosphonylmethoxyethyl-a	An acyclic nucleotide adenine analogue with potent antiviral activity. Adefovir is activated in vivo to a diphosphate metabolite which is incorporated into viral DNA, leading to viral RNA-dependent DNA polymerase inhibition, DNA chain termination and impairment of viral replication.  This agent inhibits the reverse transcriptases of hepatitis B, herpes and HIV viruses, induces natural killer cell activity, and stimulates endogenous interferon production.  Viral resistance to adefovir develops at a slower rate compared to other antivirals. (NCI04)
C28814	Allergy_Shot	Immunologic_Desensitization	Allergy Shot
C28815	Aloe_Vera	Vascular_Plant	Aloe vera|Aloe Vera	A succulent, fibrous plant, of the family Liliaceae, with basal leaves, having toothed or fibrous margins. Native to southern Africa, it is a popular ornamental, and its juice is used alone or in preparations to soothe minor burns and skin irritations. (BioTech Life Sciences Dictionary)
C28816	Alprostadil	Vasodilating_Agent	Alprostadil|(11alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic Acid|Caverject|MUSE|PGE1|Prostaglandin E1	The naturally occuring prostaglandin E1 (PGE1) which displays a variety of pharmacologic actions.  Alprostadil is a potent vasodilator agent that increases peripheral blood flow, inhibits platelet aggregation, and induces bronchodilation. Used in the treatment of erectile dysfunction, this agent produces corporal smooth muscle relaxation by binding to PGE receptors, resulting in the activation of adenylate cyclase and the subsequent accumulation of 3'5'-cAMP.
C28817	Aluminum_Magnesium	Antacid_Preparation	Aluminum Magnesium	A salt or hydroxide mixture of aluminium and magnesium metals used as an antacid, Aluminum Magnesium absorbs and neutralizes stomach acid, helping to relieve intermittent, infrequent heartburn and indigestion. Aluminium and magnesium antiacids may be used to treat symptoms of peptic ulcer, gastritis, esophagitis, hiatal hernia and gastric hyperacidity. (NCI04)
C28818	Amantadine_Hydrochloride	Miscellaneous_Antiviral_Agent	Amantadine Hydrochloride|AMANTADINE HYDROCHLORIDE|Amantadine HCl
C28819	Amitriptyline	Antidepressant_Agent	Amitriptyline Hydrochloride|AMITRIPTYLINE HYDROCHLORIDE|Amitriptyline
C28820	Amlodipine_Besylate	Calcium_Channel_Blocker	Amlodipine Besylate|AMLODIPINE BESYLATE	A dihydropyridine calcium channel blocking agent. Amlodipine besylate inhibits the influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility.  This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. Amlodipine besylate exhibits a longer half-life in vivo compared to other dihydropyridine calcium channel blocking agents. (NCI04)
C28821	Ammonium_Lactate	Topical_Preparation	Ammonium Lactate|Ammonium lactate|Lactic Acid/Ammonium Hydroxide	An organic salt of ammonium (lactic acid neutralized with ammonium hydroxide), topical moisturizing Ammonium Lactate can be applied as a humectant in ichthyosis vulgaris and xerosis. Available as cream or lotion, this agent moisturizes the skin and breaks up the scales. (NCI04)
C28822	Amphetamine	Substance_of_Abuse	Amphetamine Sulfate|AMPHETAMINE SULFATE|Amphetamine	A synthetic substance related to natural sympathomimetic amines. Amphetamine appears to exert its central nervous system (CNS) and peripheral effects indirectly by inducing the release of biogenic amines from their storage sites in nerve terminals. This agent is a commonly abused psychostimulant drug, which may be snorted, taken orally, smoked, or injected.  Amphetamine induces psychologic dependence which is manifested by elevated mood, increased wakefulness, concentration, physical performance and a feeling of well-being. With sustained use, the effects of tachycardia and enhanced alertness diminish while psychotoxic effects such as hallucinations and delusions may occur. (NCI04)
C28823	Ampicillin_Sodium-Sulbactam_Sodium	Combination_Anti-Infective_Agent	Ampicillin Sodium/Sulbactam Sodium
C28824	Amprenavir	Protease_Inhibitor	Amprenavir|141W94|Agenerase|Carbamic acid, (3-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-2-hydroxy-1-(- phenylmethyl)propyl)-, tetrahydro-3-furanyl ester, (3S-(3R*(1S*,2R*)))-|KVX 478|VX 478	A synthetic antiviral agent.  As a derivative of hydroxyethylamine sulfonamide, amprenavir selectively binds to and inhibits human immunodeficiency virus (HIV) protease, thereby preventing cleavage of the gag-pol viral polyprotein and resulting in the release of immature, noninfectious virions. (NCI04)
C28825	Anagrelide	Antiplatelet_Agent	Anagrelide	A synthetic quinazoline derivative, Anagrelide reduces platelet production through a decrease in megakaryocyte maturation. Anagrelide inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. At therapeutic doses, it does not influence white cell counts or coagulation parameters. Anagrelide is used for treatment of essential thrombocythemia to reduce elevated platelet counts and the risk of thrombosis. (NCI04)
C28826	Anagrelide_Hydrochloride	Anagrelide	Anagrelide Hydrochloride|ANAGRELIDE HYDROCHLORIDE|Agrylin|Anagrelide HCl (Agrylin)	The hydrochloride salt of a synthetic quinazoline derivative, Anagrelide Hydrochloride reduces platelet production through a decrease in megakaryocyte maturation. Anagrelide inhibits cyclic AMP phosphodiesterase, as well as ADP- and collagen-induced platelet aggregation. At therapeutic doses, it does not influence white cell counts or coagulation parameters. Anagrelide is used for treatment of essential thrombocythemia to reduce elevated platelet counts and the risk of thrombosis. (NCI04)
C28827	Anthralin	Anti-psoriatic_Agent	Anthralin|1,8-Dihydroxy-9(10H)-anthracenone	A natural anthraquinone derivative, anti-psoriatic and anti-inflammatory Anthralin (dithranol) controls skin growth by reducing DNA synthesis and mitotic activity in the hyperplastic epidermis, restoring a normal rate of cell proliferation and keratinization. Used topically in the treatment of psoriasis, dermatoses, and alopecia areata, it is also used in biomedical research due to its effect on EGFR autophosphorylation. (NCI04)
C28831	Apheresis	Retired_Concepts	Apheresis|Hemapheresis|apheresis
C28832	Aquaphor	Drug_Vehicle	Aquaphor	A petrolatum-based ointment absorbed by dry and moist skin, Aquaphor is non-comedogenic, non-irritating, and non-sensitizing. It can reduce healing time of cracked, dry skin on hands, elbows, and knees, and helps prevent diaper rash. The original ointment also contained mineral oil, ceresin, lanolin alcohol. Its use is indicated in atopic dermatitis, eczema, and psoriasis when extra protection from a heavier base is needed. (NCI04)
C28833	Argatroban	Anticoagulant_Agent	Argatroban|Argatrodan|Argipidine|MD-805
C28834	Astemizole	Histamine-1_Receptor_Antagonist	Astemizole|Hismanal	A synthetic piperidinyl-benzimidazol derivative with antiallergic properties, Astemizole acts as a reversible competitive inhibitor of histamine H1 receptors, with less anticholinergic effects compared to related agents. It is a long-acting, non-sedative antihistaminic used in the treatment of seasonal allergic rhinitis, asthma, allergic conjunctivitis, and chronic idiopathic urticaria. (NCI04)
C28835	Atazanavir	Protease_Inhibitor	Atazanavir Sulfate|ATAZANAVIR SULFATE|Atazanavir|BMS-232632|CGP-73547|Reyataz	A synthetic antiviral agent.  As a symmetric azapeptide agent structurally different from other HIV protease inhibitors, atazanavir selectively binds to and inhibits human immunodeficiency virus (HIV) protease, thereby preventing cleavage of the gag-pol viral polyprotein and resulting in the release of immature, noninfectious virions.  This agent does not elevate serum lipids, a common problem with other protease inhibitors. (NCI04)
C28836	Atenolol	Beta-Adrenergic_Blocking_Agent	Atenolol|ATENOLOL	A synthetic isopropylamino-propanol derivative used as an antihypertensive, hypotensive and antiarrhythmic Atenolol acts as a peripheral, cardioselective beta blocker specific for beta1-receptors, without intrinsic sympathomimetic effects. It reduces exercise heart rates and delays atrioventricular conduction, with overall oxygen requirements decreasing. (NCI04)
C28837	Atorvastatin	HMG-CoA_Reductase_Inhibitor	Atorvastatin|(betaR,deltaR)-2-(4-Fluorophenyl)-beta,delta-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic Acid|(betaR,deltaR)-2-(p-Fluorophenyl)-beta,delta-dihydroxy-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-pyrrole-1-heptanoic Acid|Atorvastatin Calcium|CI-981|Lipitor	A synthetic lipid-lowering agent.  Atorvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis.  Atorvastatin also increases the number of LDL receptors on hepatic cell surfaces to enhance uptake and catabolism of LDL and reduces LDL production and the number of LDL particles.  This agent lowers plasma cholesterol and lipoprotein levels and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)
C28838	Atovoquone	Antiprotozoal_Agent	Atovoquone|566C80|ATOVAQUONE|BW-566C|BW-A566C|Mepron
C28839	Atracuruim_Besylate	Muscle_Relaxant	Atracurium Besylate	A synthetic dibenzensulfonate derivative muscle relaxant, Atracurium Besylate acts as a non-depolarizing neuromuscular blocking agent, with short to intermediary duration of action and no significant cardiovascular effects. Not dependent on kidney function for elimination, it provides clinical advantages over other non-depolarizing, neuromuscular blocking agents. (NCI04)
C28840	Atropine	Antimuscarinic_Agent	Atropine|ATROPINE|dl-Tropyl Tropate|endo-(+/-)-alpha-(Hydroxymethyl)benzeneacetic Acid 8-methyl-8-azabicyclo[3.2.1]oct-3-yl Ester	A synthetically-derived form of the endogenous alkaloid isolated from the plant Atropa belladonna.  Atropine functions as a sympathetic, competitive antagonist of muscarinic cholinergic receptors, thereby abolishing the effects of parasympathetic stimulation.  This agent may induce tachycardia, inhibit secretions, and relax smooth muscles. (NCI04)
C28841	Attapulgite	Antidiarrheal_Agent	Attapulgite	A natural clay-like mineral mixture of hydrated aluminum silicate containing magnesium, adsorbent Attapulgite (kaopectate) acts locally in the intestines to adsorb bacteria and toxins; reduce water loss; and treat diarrhea. Sometimes it is activated by heat to increase absorbency. (NCI04)
C28842	Autologous_Epstein-Barr_Virus-Specific_Cytotoxic_T_Lymphocytes	Autologous_Lymphocytes	Therapeutic Autologous Epstein-Barr Virus-Specific Cytotoxic T Lymphocytes|Autologous Epstein-Barr Virus-Specific Cytotoxic T Lymphocytes|Epstein-Barr Virus-Specific Cytotoxic T Lymphocytes|LMP2A CTL|LMP2A-Specific Cytotoxic T-Lymphocytes	A preparation of lymphocytes harvested from a patient with an Epstein-Barr virus (EBV)-positive tumor.  Ex vivo, the lymphocytes are activated against EBV-specific antigens and then returned to the patient, where they mount a specific immune response against EBV-positive tumor cells. (NCI04)
C28844	Azithromycin	Macrolide_Antibiotic	Azithromycin|(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[(3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentad|(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-alpha-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[(3,4,6-trideoxy-3-(dimethylamino)-beta-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentade|CP 62993|N-methyl-11-aza-10-deoxy-10-dihydroerythromycin A|XZ-450|Zithromax
C28845	Aztreonam	Beta-Lactam_Antibiotic	Aztreonam|AZTREONAM|Azactam|SQ 26,776
C28847	B3_90YB3_111Y-B3	Retired_Concepts	B3/90YB3/111Y-B3
C28850	Bactobolin	Miscellaneous_Antineoplastic_Antibiotic	Bactobolin|(-)-Bactobolin|2-Amino-N-[3-(dichloromethyl)-3,4,4a,5,6,7- hexahydro-5,6,8-trihydroxy-3-methyl-1-oxo-1H-2- benzopyran-4-yl], Propanamide|Antibiotic BN 183B|BN 183B|Y 12278	A 3-dichloromethylactinobolin antineoplastic antibiotic isolated from various Pseudomonas bacterial species.  BN-183 induces apoptosis via a caspase-dependent pathway.  This agent also has immunomodulatory properties. (NCI04)
C28851	Baculovirus_CEA_Protein_Vaccine	Antineoplastic_Vaccine	Baculovirus CEA Protein Vaccine|CEA Vaccine	A vaccine consisting of recombinant carcinoembryonic antigen (CEA) produced by a baculovirus expression system with potential antineoplastic activity.  Vaccination with baculovirus CEA protein vaccine stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against CEA positive cells, resulting in decreased tumor growth.  CEA is overexpressed in several cancer cell types, including gastrointestinal, breast, and non-small cell lung cancers. (NCI04)
C28852	Baculovirus-Derived_PSA_Protein	Antineoplastic_Vaccine	Baculovirus-Derived PSA Protein Vaccine|Baculovirus-Derived PSA Protein	A recombinant human prostate-specific antigen (PSA) protein expressed by baculovirus.  Baculovirus-derived PSA protein is cross-reactive with native PSA, and has potential use in immunotherapy for prostate cancer. (NCI04)
C28854	BLED	Retired_Concepts	BLED
C28855	Breflate	Unclassified_Chemotherapy_Agent	Breflate|13-(N,N-Dimethylglycyl)brefeldin A	A water soluble analogue of the antineoplastic agent brefeldin A (BFA). (NCI04)
C28856	BVCPP	Retired_Concepts	BVCPP
C28857	Bacitracin_Zinc	Bacitracin	Bacitracin Zinc
C28858	Baclofen	Muscle_Relaxant	Baclofen|4-Amino-3-(4-chlorophenyl)-butanoic Acid|BA34647|BACLOFEN|Lioresal|beta-(Aminomethyl)-4-chlorobenzenepropanoic Acid	A synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing Baclofen acts as a gamma-aminobutyric acid (GABA) agonist specific for GABA-B receptors. It acts at spinal and supraspinal sites, reducing excitatory transmission. (NCI04)
C28859	Barium_Sulfate	Contrast_Agent	Barium Sulfate|BARIUM SULFATE	The sulfate salt of barium, an alkaline, divalent metal.  Barium sulfate is quite insoluble in water, and is used as a radiopaque agent to diagnose gastrointestinal medical conditions.  Barium sulfate is taken by mouth or given rectally. (NCI04)
C28860	Bcl-Xs_Adenovirus_Vaccine	Antineoplastic_Vaccine	Bcl-Xs Adenovirus Vaccine|Bcl-Xs Adenovirus vaccine	A vaccine consisting of replication-defective recombinant adenovirus that encodes for Bcl-Xs with potential antineoplastic activity.  Vaccination with Bcl-Xs adenovirus vaccine induces apoptosis in Bcl-2 and Bcl-XL positive cancer cells, resulting in decreased tumor growth while leaving normal cells unaffected.  Bcl-Xs block the function of the protooncogenes Bcl-2 and Bcl-XL which are overexpressed in a variety of solid tumors and promote cancer cell survival by inhibiting apoptosis. (NCI04)
C28861	Belladona_Phenobarbital_Ergotamine	Miscellaneous_Adjuvant	Belladonna/Phenobarbital/Ergotamine|Belladonna/Phenobarb/Ergotamine|Bellergal-S	Used to relieve stomach/intestinal symptoms, menopause (hot flashes, sweats, restlessness, and insomnia), headaches, and tachycardia, Belladona Phenobarbital Ergotamine is a combination of an Atropa belladonna alkaloid, a Claviceps purpurea (Ergotamine) alkaloid, and a synthetic barbiturate. Parasympathomimetic Belladona decreases secretion, smooth muscle stimulant Ergotamine blocks alpha-adrenergic activity, and sedative Phenobarbital induces sleep. (NCI04)
C28862	Benazepril_Hydrochloride	ACE_Inhibitor	Benazepril Hydrochloride|BENAZEPRIL HYDROCHLORIDE|Benazepril HCl|CGS14824A|Lotensin	A synthetic benzazepine derivative used with other agents for hypertension.  Benazepril is metabolized to active benazeprilat, a non-sulfhydryl angiotensin-converting enzyme inhibitor that decreases vasoconstrictor angiotensin ll. (NCI04)
C28863	Benzonatate	Miscellaneous_Adjuvant	Benzonatate|KM-65|Tessalon	A synthetic butylamino-benzoate derivative related to tetracaine and a peripherally acting antitussive, nonnarcotic Benzonatate reduces the cough reflex by anesthetizing and depressing mechanoreceptors in the respiratory passages, lungs, and pleura. It is recommended for cough relief in the common cold, bronchitis, pneumonia, and for chronic cough such as in asthma. (NCI04)
C28864	Benztropine_Mesylate	Antimuscarinic_Agent	Benztropine Mesylate	A synthetic antiparkinson tertiary amine structurally related to atropine, Benztropine Mesylate acts as a central muscarinic antagonist and inhibits dopamine uptake. With antihistaminic and local anesthetic properties as well, it is indicated for symptomatic relief of parkinsonism and drug-induced extrapyramidal reactions. (NCI04)
C28865	Benzylpenicillin_Sodium	Penicillin_Antibiotic	Benzylpenicillin Sodium|4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3,3-dimethyl-7-oxo-6-((phenylacetyl)amino)-,(2S-(2alpha,5alpha,6beta))-, Monosodium Salt|Benzylpenicillin Sodium Salt|Novocillin|PENICILLIN G SODIUM|Penicillin|Penicillin G Sodium|Penilaryn|Sugracillin Sodium Salt|Veticillin
C28866	Bethanechol_Chloride	Antimuscarinic_Agent	Bethanechol Chloride|2-[(Aminocarbonyl)oxy]-N,N,N-trimethyl-1-propanaminium Chloride|BETHANECHOL CHLORIDE	A synthetic quaternary ammonium base derivative, parasympathomimetic Bethanechol is a slowly hydrolyzed muscarinic agonist with no nicotinic effects. Generally used to increase smooth muscle tone, Bethanechol is used to treat reflux esophagitis and to initiate urination after surgery, in urinary infections, or for enlarged prostate. It may cause hypotension, cardiac rate changes, and bronchial spasms. (NCI04)
C28867	Sodium_Bicarbonate-Aspirin-Citric_Acid	Analgesic_Preparation	Sodium Bicarbonate/Aspirin/Citric Acid|Alka Seltzer|Bicarb/ASA.Citric Acid|Bicarb/ASA/Citric Acid
C28868	Biotene_Mouthwash	Miscellaneous_Adjuvant	Biotene Mouthwash	Formulated for oral hygiene, Biotene Mouthwash contains antibacterial enzymes that boost natural salivary antibacterial defenses, protects teeth and gums, and provides relief or prevents dry mouth (xerostomia) induced by some drug therapies, as well as by acute renal failure, bone marrow transplant, hypertension, kidney dialysis, stroke, and radiation therapy. (NCI04)
C28869	Biotope_CD	Non-Viral_Vector-Gene_Complex	Biotope CD|ZY101	A non-viral expression system using multifunctional plasmid DNA to deliver disease-specific to immune cells and encode peptides/proteins to modulate various diseases. (NCI04)
C28870	Bisacodyl	Laxative	Bisacodyl|BISACODYL	A synthetic pyridinylmethylene-diacetate ester derivative stimulant laxative, Bisacodyl acts with a parasympathetic effect directly on mucosal sensory nerves, increasing peristaltic contractions. It is used for occasional constipation, in pre- and postoperative treatment, and in conditions that require facilitation of defecation. (NCI04)
C28871	Bisoprolol_Fumarate	Beta-Adrenergic_Blocking_Agent	Bisoprolol Fumarate|BISOPROLOL FUMARATE	A synthetic phenoxy-2-propanol derivative, antihypertensive Bisoprolol Fumarate acts as a selective beta-1 (cardio) adrenergic antagonist, without membrane stabilizing activity or intrinsic sympathomimetic activity. Used in the management of hypertension and angina pectoris, Bisoprolol may target bronchial and vascular beta-2 adrenoreceptors at higher doses. (NCI04)
C28872	Bisoprolol-Fumarate_Hydrochlorothiazide	Antihypertensive_Preparation	Bisoprolol Fumarate/Hydrochlorothiazide|Bisoprolol Fumarate/Hydrochlorithiazide|Ziac	A combination of a synthetic antihypertensive phenoxy-2-propanol derivative and a diuretic thiazide used for hypertension, Bisoprolol Fumarate Hydrochlorothiazide acts as a selective beta-1 (cardio) adrenergic antagonist, without membrane stabilizing activity or intrinsic sympathomimetic activity. Hydrochlorothiazide affects renal tubular electrolyte reabsorption, increasing excretion of sodium and chloride. (NCI04)
C28873	Brimodine	Alpha-adrenergic_Agonist	Brimodine	A synthetic quinoxaline derivative, Brimodine (brimonidine) acts as a relatively selective alpha-2 adrenergic receptor agonist. Used for open angle glaucoma and eye hypertension, topical administration decreases intraocular pressure with minimal effect on cardiovascular parameters, reducing aqueous humor production and increasing uveoscleral outflow. (NCI04)
C28874	Bromocryptine	Retired_Concepts	Bromocryptine|(5'alpha)-2-Bromo-12'-hydroxy-2'-(1-methylethyl)-5'-(2-methylpropyl)ergotaman-3',6',18-trione|2-Bromo-alpha-ergocryptine|Bromoergocryptine|CB-154
C28875	Bumetanide	Diuretic	Bumetanide|BUMETANIDE|Bumex	A synthetic butylamino-sulfamoylbenzoic acid derivative, Bumetanide is a loop diuretic that inhibits sodium reabsorption in the ascending limb of the loop of Henle; potassium excretion is increased in a dose-related fashion. Bumetanide is used for edema associated with congestive heart failure, cirrhosis, and nephrotic syndrome. (NCI04)
C28876	Bupivacaine	Anesthetic_Agent	Bupivacaine Hydrochloride|BUPIVACAINE HYDROCHLORIDE|Bupivacaine
C28877	CAP-2_CEA_Peptide_9-mer	Tumor_Specific_Peptide	CAP-2 (CEA Peptide 9-mer)
C28878	CAP-3_CEA_Peptide_9-Mer	Tumor_Specific_Peptide	CAP-3 (CEA Peptide 9-mer)
C28879	Carbestrol	Miscellaneous_Hormone_Agent	Carbestrol|3-Ethyl-4-(p-methoxyphenyl)-2-methyl-3-cyclohexene-1-carboxylic acid|U-2911
C28880	CC49-218_sFv	Immunoconjugate	CC-49/218 sFv|CC-49/218 SFV	An immunoglobulin derived from the single-chain antigen-binding domain (sFv) of the monoclonal antibody CC-49 with potential antineoplastic activity.  The parent monoclonal antibody CC-49 binds to the tumor-associated glycoprotein TAG-72 with high affinity, recognizing many tumor cell types that express TAG-72. Because of its single-chain structure, CC-49/218 sFv may exhibit a longer half-life than the parent monoclonal antibody CC-49; 218 represents the linker sequence that helps reduce aggregation and proteolysis of this agent.  (NCI04)
C28882	Cesalin	Intercalating_Agent|Miscellaneous_Antimetabolite	Cesalin	An antineoplastic protein isolated from the seeds of the plant Caesalpinia gilliesii with antineoplastic activity.  Cesalin intercalates into and crosslinks DNA and inhibits the incorporation of the nucleotides uridine and thymidine into DNA, thereby inhibiting DNA and protein synthesis. (NCI04)
C28883	CH-296_Fibronectin	Viral_Vector-Gene_Complex	CH-296 Fibronectin
C28884	Chelate_Monoclonal_Antibody_B72_3	Immunoconjugate	Chelate-Monoclonal Antibody B72.3|Chelate B72.3 MOAB|M A B72.3 (Chelated)
C28885	Chimeric_Antibody_CHCC49	Monoclonal_Antibody	Chimeric Antibody CHCC49
C28886	Chimeric_Monoclonal_Antibody_B72_3	Monoclonal_Antibody	Chimeric Monoclonal Antibody B72.3|Chimeric B72.3|MOAB CHIM B72.3 (LD)	A synthetic chimeric molecule in which a mouse monoclonal antibody variable region directed against the tumor-associated glycoprotein 72 (TAG-72) is fused to a human antibody constant region. This agent reacts to most human adenocarcinomas (colorectal, gastric, pancreatic, ovarian, endometrial, mammary) but has weak or undetectable reactivity to most normal tissues. (NCI04)
C28888	Clomesone	Alkylsulfonate_Compound	Clomesone	The 2-chloroethyl ester of (methylsulfonyl) methanesulfonic acid with potential antineoplastic effects.  Acting as a chloroethylating agent, clomesone induces the formation of DNA interstrand crosslinks in some cell lines, and exhibits antitumor activity in some animal models.  Alkylating agents exert cytotoxic and, in some cases, chemotherapeutic effects by transferring alkyl groups to DNA, thereby damaging DNA and interfering with DNA synthesis and cell division. (NCI04)
C28890	Cyclophosphamide_Mechlorethamine_Prednisone_Procarbazine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Mechlorethamine/Prednisone/Procarbazine/Vincristine|C-MOPP|CMOPP
C28891	CODP-WAC	Retired_Concepts	CODP-WAC
C28893	Monoclonal_Antibody_COL-1	Monoclonal_Antibody	Monoclonal Antibody COL-1|COL 1|COL-1	A recombinant immunoglobulin antibody directed against the tumor-associated antigen carcinoembryonic antigen (CEA). CEA is a cell surface glycoprotein expressed at high levels in embryonic and fetal digestive epithelial tissue, breast carcinoma, and squamous cell carcinoma of the head and neck. Except for some reactivity to skin and gastric and colon mucosa, monoclonal antibody COL-1COL-1 does not appear to react with normal tissues. (NCI04)
C28896	Cremophor	Drug_Vehicle	Cremophor|Polyethoxylated Castor Oil
C28898	CTLA4-Ig	Immunoconjugate|Immunosuppressant	CTLA4-Ig|BMS-188667|CTL A4-Ig B7 Inhibitor
C28899	Cyclodisone	Alkylsulfonate_Compound	Cyclodisone	A cyclic sulfonate ester with potential antineoplastic activity.  As an alkylating agent, clyclodisone induces the formation of DNA interstrand crosslinks, DNA strand breaks, and alkali-labile lesions in the DNA of some tumor cell lines.  Alkylating agents exert cytotoxic and chemotherapeutic effects by transferring alkyl groups to DNA, thereby damaging DNA and interfering with DNA synthesis and cell division. (NCI04)
C28900	Calcipotriene	Anti-psoriatic_Agent	Calcipotriene|CALCIPOTRIENE|Dovonex	A synthetic vitamin D derivative usually formulated for topical dermatological use, antipsoriatic Calcipotriene (calcipotriol) competes equally with active 1,25-hydroxy-2D3 (the natural form of vitamin D) for 1,25-hydroxy-2D3 receptors in regulating cell proliferation and differentiation. It induces differentiation and suppresses proliferation of keratinocytes, reversing abnormal keratinocyte changes in psoriasis, and leads to normalization of epidermal growth. (NCI04)
C28901	Calcium_Chloride	Electrolyte_Replacement_Agent	Calcium Chloride|Calcium Chloride Anhydrous|Calcium Chloride Dihydrate|Calcium Chloride Hexahydrate	A crystalline, white substance, soluble in water, Calcium Chloride is the chloride salt of calcium, a bivalent metallic element with many crucial biological roles. Calcium is a major constituent of the skeleton but plays many roles as an intracellular and plasma ion as well. In medicine, calcium chloride is also used as a 10% solution in injection, for calcium replenishment. (NCI04)
C28902	Calcium_Polycarbophil	Antidiarrheal_Agent	Calcium Polycarbophil|Fiberall|Fibercon|Mitrolan	A loosely cross-linked synthetic polycarboxylic-type hydrophilic polymer resin, laxative and anti-diarrheal Calcium Polycarbophil increases stool frequency, fecal water content, and fecal weight in a dose-dependent manner. It is used for idiopathic constipation, secretory diarrhea, and irritable bowel syndrome. (NCI04)
C28903	Candesartan_Cilexetil	Antihypertensive_Agent	Candesartan Cilexetil|Atacand|CANDESARTAN CILEXETIL	A synthetic antihypertensive benzimidazole-carboxylate derivative, Candesartan Cilexetil (Candesartan prodrug) selectively blocks angiotensin ll binding to specific receptors, inducing vasodilation and reduced aldosterone production. With other hypotensive agents, it is indicated in hypertension. (NCI04)
C28904	Carisoprodol	Muscle_Relaxant	Carisoprodol|CARISOPRODOL|Soma	A synthetic propanediol dicarbamate derivative and an adjunct in the treatment of painful muscle spasms, Carisoprodol is a centrally acting skeletal muscle relaxant that relieves stiffness, pain, and discomfort caused by muscle injuries. Its mechanism of action is not clear yet; perhaps due to its sedative actions. (NCI04)
C28905	Carteolol_Hydrochloride	Beta-Adrenergic_Blocking_Agent	Carteolol Hydrochloride|CARTEOLOL HYDROCHLORIDE|Carteolol HCl	A synthetic quinolinone derivative, antihypertensive Carteolol Hydrochloride is a nonselective beta-adrenoceptor blocking agent for beta-1 and beta-2 receptors with no membrane-stabilizing activity but moderate intrinsic sympathomimetic effects. It is used for treatment of hypertension and certain arrhythmias, and as an anti-angina and antiglaucoma agent. (NCI04)
C28906	Carvedilol	Beta-Adrenergic_Blocking_Agent	Carvedilol|CARVEDILOL|Coreg	A synthetic antihypertensive methoxyphenoxy- 2-propanol derivative with no intrinsic sympathomimetic activity, Carvedilol acts as a nonselective beta-adrenoceptor blocking agent (S(-) enantiomer) and as an alpha 1-adrenoceptor blocker (R(+) and S(-) enantiomers). Its acts more strongly on beta-receptors than on alpha 1-receptors, reduces peripheral vascular resistance by vasodilation, and prevents reflex tachycardia (beta-blockade) so that heart rate is either unchanged or decreased. Carvedilol also reduces renin release through beta-blockade. (NCI04)
C28907	Casanthranol	Laxative	Casanthranol	A concentrated mixture of anthranol glycosides from cascara sagrada (dried bark of Rhamnus p.) and used as a laxative in constipation and various medical conditions, stimulant laxative Casanthranol encourages bowel movements by acting on the intestinal wall to increase muscle contractions. (NCI04)
C28908	Casanthranol_Docusate	Laxative_Preparation	Casanthranol/Docusate|Peri-Colace	A combination of laxatives, Casanthranol Docusate is used in constipation and various medical conditions. Casanthranol is a concentrated mixture of anthranol glycosides from cascara sagrada (dried bark of Rhamnus p.) and a stimulant laxative that encourages bowel movements by acting on the intestinal wall to increase muscle contractions. A surface-active emollient, stool softener Docusate helps liquids to mix into dry stool, allowing patients to have a bowel movement without straining. (NCI04)
C28909	Cascara	Laxative	Cascara	Used as a laxative in constipation and various medical conditions, Cascara (cascara sagrada) is dried bark of Picramnia sp. (Simarubaceae) or Rhamnus purshiana (Rhamnaceae) containing stimulant laxative anthranol glycosides that act on the intestinal wall to increase muscle contractions and encourage bowel movements. (NCI04)
C28910	Caspofungin	Antifungal_Agent	Caspofungin	The acetate salt of an antimycotic echinocandin lipopeptide, semisynthetically derived from a fermentation product of the fungus Glarea lozoyensis. Caspofungin inhibits 1,3-beta-glucan synthase, resulting in decreased synthesis of beta(1,3)-D-glucan (an essential component of the fungal cell wall), weakening of the fungal cell wall, and fungal cell wall rupture. This agent is active against Aspergillus and Candida species.
C28911	Cefaclor	Cephalosporin_Antibiotic	Cefaclor|CEFACLOR
C28912	Cefadroxil	Cephalosporin_Antibiotic	Cefadroxil|(6R,7R)-7-(((2R)-Amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid|CEFADROXIL|Duricef
C28913	Cefazolin	Cephalosporin_Antibiotic	Cefazolin|(6R,7R)-3-(((5-Methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(2-(1H-tetrazol-1-yl)acetamido)-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid|CEFAZOLIN
C28914	Cefdinir	Cephalosporin_Antibiotic	Cefdinir
C28915	Cefoxitin_Sodium	Cephalosporin_Antibiotic	Cefoxitin Sodium|CEFOXITIN SODIUM
C28916	Cefpodoxime	Cephalosporin_Antibiotic	Cefpodoxime
C28917	Cefprozil	Cephalosporin_Antibiotic	Cefprozil
C28918	Cefurexine_Axetil	Cephalosporin_Antibiotic	Cefuroxime Axetil|Cefurexine Axetil
C28919	Cerivastatin_Sodium	HMG-CoA_Reductase_Inhibitor	Cerivastatin Sodium	The sodium salt of a synthetic lipid-lowering agent.  Cerivastatin sodium competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis.  This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. Muscle toxicity (myopathy and rhabdomyolysis) precludes the clinical use of this agent. (NCI04)
C28920	Cetirizine_Hydrochloride	Cetirizine	Cetirizine Hydrochloride|CETIRIZINE HYDROCHLORIDE|Cetirizine HCl|Zyrtec	A synthetic phenylmethyl-piperazinyl derivative, antihistaminic Cetirizine is a metabolite of hydroxyzine and a selective peripheral histamine H1-receptor antagonist. It is used for symptomatic treatment of seasonal and perennial allergic rhinitis and for chronic urticaria. (NCI04)
C28922	Chloral_Hydrate	Adjuvant_Analgesic	Chloral Hydrate
C28923	Benzocaines	Anesthetic_Agent	Benzocaines|Benzocaine|Chloraseptic
C28924	Chlorothiazide	Diuretic	Chlorothiazide|CHLOROTHIAZIDE|Diuril	A synthetic thiazide derivative similar to hydrochlorothiazide and used in the treatment of edema, hypertension, diabetes insipidus, and hypoparathyroidism, diuretic Chlorothiazide reduces renal tubule electrolyte reabsorption and increases water and electrolyte excretion (sodium, potassium, chloride, and magnesium). (NCI04)
C28925	Chlorpheniramine_Maleate	Histamine-1_Receptor_Antagonist	Chlorpheniramine Maleate|CHLORPHENIRAMINE MALEATE|Chlor-Trimeton|Dexchloropheniramine Maleate|Polaramine|gamma-(4-Chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine (Z)-2-butenedioate	A synthetic alkylamine derivative used in allergic reactions, hay fever, rhinitis, urticaria, and asthma, antihistamine Chlorpheniramine Maleate acts as a competitive histamine H1 receptor antagonist, and displays anticholinergic and mild sedative effects as well. (NCI04)
C28926	Chlorzoxazone	Muscle_Relaxant	Chlorzoxazone|CHLORZOXAZONE|Paraflex	A synthetic chlorobenzoxazolinone derivative, mild sedative, and centrally acting muscle relaxant in acute painful musculoskeletal diseases, Chlorzoxazone acts at the spinal cord and subcortical levels of the brain to inhibit multisynaptic reflex arcs that maintain muscle spasms. (NCI04)
C28927	Chlorzoxazone_Acetaminophen	Muscle_Relaxant_Preparation	Chlorzoxazone/Acetaminophen|Parafon Forte	Chlorzoxazone Acetaminophen is a combination of muscle relaxant (Chlorzoxazone) and anti-inflammatory analgesic (Acetaminophen) indicated in acute painful musculoskeletal diseases. The active principal metabolite of phenacetin, Acetaminophen appears to inhibit prostaglandin biosynthesis in the central nervous system and less in peripheral tissues. With mild sedative properties, centrally acting Chlorzoxazone inhibits muscle spasm at the spinal cord and subcortical levels of the brain. (NCI04)
C28928	Chlotrimazole	Retired_Concepts	Chlotrimazole|Gyne-Lotrimin|Lotrimin|Mycelex
C28929	Cholestyramine	Anti-lipidemic_Agent|Nephroprotective_Agent	Cholestyramine	An anion exchange resin.  Cholestyramine resin adsorbs and combines with bile acids in the intestine to form an insoluble complex, which is then excreted in the feces.  As a result, the absorption of bile acids from the enterohepatic circulation is partially prevented, resulting in an increased oxidation of cholesterol to bile acids, a decrease in low density lipoprotein in the plasma, and a decrease in serum cholesterol levels.  Cholestyramine also increases the elimination of methotrexate and leflunomide, thereby potentially decreasing related toxicities. (NCI04)
C28931	Chromium_Piccolinate	Anti-diabetic_Agent	Chromium Picolinate	Chromium Piccolinate is a salt of the trace metallic element chromium (Cr), essential in glucose metabolism. Found in vitamins and mineral supplements, Chromium may be necessary for utilization of dietary sugars and carbohydrates by optimizing the effects of insulin. Animal studies suggest that chromium picolinate may be carcinogenic, it enters cells directly and can causes mutations. (NCI04)
C28932	Citalopram_Hydrobromide	Antidepressant_Agent	Citalopram Hydrobromide|CITALOPRAM HYDROBROMIDE
C28933	Citrucel	Retired_Concepts	Methylcellulose|Citrucel
C28934	Clobetasol_Propionate	Therapeutic_Glucocorticoid	Clobetasol Propionate|CLOBETASOL PROPIONATE
C28935	Clonazepam	Anticonvulsant_Agent|Benzodiazepine	Clonazepam|CLONAZEPAM	A synthetic benzodiazepine derivative used for myotonic or atonic seizures, absence seizures, and photosensitive epilepsy, anticonvulsant Clonazepam appears to enhance gamma-aminobutyric acid receptor responses, although its mechanism of action is not clearly understood. It is seldom effective in generalized tonic-clonic or partial seizures. (NCI04)
C28936	Clozapine	Antipsychotic_Agent	Clozapine|CLOZAPINE	A synthetic dibenzo-diazepine derivative, atypical antipsychotic Clozapine blocks several neurotransmitter receptors in the brain (dopamine type 4, serotonin type 2, norepinephrine, acetylcholine, and histamine receptors). Unlike traditional antipsychotic agents, it weakly blocks dopamine type 2 receptors. It relieves schizophrenic symptoms (hallucinations, delusions, dementia). (NCI04)
C28937	Colesevelam_Hydrochloride	Anti-lipidemic_Agent	Colesevelam Hydrochloride|Colesevelam HCl|Welchol	A polymeric synthetic polyallylamine derivative cross-linked with epichlorohydrin, Colesevelam Hydrochloride is a non-absorbed, water-insoluble, lipid-lowering, hydrophilic agent that binds intestinal bile acids and impedes their reabsorption. Used alone or with other medications, Colesevelam increases cholesterol metabolism and decreases its plasma concentration. (NCI04)
C28938	Colestipol_Hydrochloride	Anti-lipidemic_Agent	Colestipol Hydrochloride|Colestid|Colestipol HCl	A synthetic triamine and epoxypropane copolymer used alone or with other medications, oral Colestipol Hydrochloride is a cholesterol-lowering bile acid-binding agent that acts as a non-absorbed intestinal anion-exchange resin. By reducing absorption of bile acids, it increases their production from cholesterol and reduces the amount of plasma cholesterol. (NCI04)
C28939	Lamivudine_Zidovudine	Chemotherapy_Regimen	Lamivudine/Zidovudine|Combivir	A combination of two synthetic nucleoside analogues with synergistic antiviral properties.  Lamivudine is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP); zidovudine is phosphorylated to its active 5'-triphosphate metabolite, zidovudine triphosphate (ZDV-TP). These active metabolites inhibit human immunodeficiency virus (HIV) viral reverse transcriptase (RT) by incorporating into viral DNA and terminating viral DNA chain elongation. (NCI04)
C28940	Comtrex	Cough_and_Cold_Preparation	Comtrex
C28941	Cortrsyn	Diagnostic_Reagent	Cortrosyn|COSYNTROPIN|Cosyntropin	A synthetically-derived subunit of the endogenous peptide pituitary hormone adrenocorticotropic hormone (ACTH).  Consisting of the first 24 amino acids from the amino terminal of ACTH, Cortrosyn is usually prepared for injection and intended for diagnostic and not therapeutic use.  Similar to endogenous ACTH, this agent stimulates the adrenal secretion of specific adrenal steroids that can be measured in the plasma. (NCI04)
C28942	Cosanthranol	Retired_Concepts	Casanthranol|Cosanthranol
C28943	Cranberry	Fruit_and_Vegetable	Cranberry	Fruit of the Cranberry plant, a Native American wetland plant, can be consumed whole or made into food products such as jellies and juices. Prevention of urinary tract infections by cranberries has been documented. Natural, unprocessed cranberries contain anthocyanidins, which prevent Escherichia coli, the typical cause urinary tract infections, from attaching to the urinary tract wall. Anthocyanidins are potent antioxidant substances. (NCI04)
C28944	Cream	Semisolid_Dosage_Form	Cream Dosage Form|CREAM|Cream|Cream Dose Form	A semisolid dosage form containing one or more drug substances dissolved or dispersed in a suitable base; more recently, the term has been restricted to products consisting of oil-in-water emulsions or aqueous microcrystalline dispersions of long chain fatty acids or alcohols that are water washable and more cosmetically and aesthetically acceptable.
C28945	Creatine_Supplement	Nutritional_Supplement	Creatine Supplement	Dietary Creatine Supplement, complements endogenous creatine produced in the liver, kidneys, and pancreas. An amino acid found in muscle cells, creatine phosphate stores energy for contraction. After intense effort, when ATP deposits are depleted, creatine phosphate donates phosphate groups toward the fast synthesis of ATP. Malnourished individuals benefit most from the increase of creatine in muscles after exogenous creatine supplement. (NCI04)
C28946	Cromolyn_Sodium	Mast_Cell_Stabilizer	Cromolyn Sodium|5,5'-[(2-Hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic Acid], Disodium Salt|CROMOLYN SODIUM|DSCG|Disodium Cromoglycate|Intal|Nasalcrom|Sodium Cromoglycate
C28947	Cyclobenzaprine	Muscle_Relaxant	Cyclobenzaprine|Flexeril
C28948	Cyclopentolate_Hydrochloride	Mydriatic_Agent	Cyclopentolate Hydrochloride|CYCLOPENTOLATE HYDROCHLORIDE|Cyclopentolate HCl
C28949	Cyproheptadine_Hydrochloride	Antihistamine	Cyproheptadine Hydrochloride|Cyproheptadine HCl|Periactin	The hydrochloride salt of a synthetic methyl-piperidine derivative with antihistaminic and anti-serotoninergic properties.  Cyproheptadine competes with free histamine (HA) for binding at HA-receptor sites, thereby competitively antagonizing histamine stimulation of HA-receptors in the gastrointestinal tract, large blood vessels, and bronchial smooth muscle. This agent also competes with free serotonin for binding at serotonin receptor sites. Cyproheptadine exhibits anticholinergic and sedative properties and has been shown to stimulate appetite and weight gain. (NCI04)
C28950	Cytochlor	Radiosensitizing_Agent	Cytochlor	A radio-sensitizing pyrimidine nucleoside with potential antineoplastic activity.  Cytochlor is metabolized first to a phosphate derivative, CldCMP, by the enzyme deoxycytidine kinase and then to the active uracyl derivative, CldUMP, by the enzyme dCMP deaminase; deoxycytidine kinase and dCMP deaminase have been found in abnormally high concentrations in most cancers. CldUMP, the active metabolite, incorporates into DNA and, upon exposure to radiation, induces the formation of uracil radicals and double-strand DNA breaks. (NCI04)
C28952	Tetrandrine	Calcium_Channel_Blocker|Immunosuppressant	Tetrandrine|D-Tetrandrine	A natural, bis-benzylisoquinoline alkaloid isolated from the root of the plant Radix stephania tetrandrae.  Tetrandrine non-selectively inhibits calcium channel activity and induces G1 blockade of the G1 phase of the cell cycle and apoptosis in various cell types, resulting in immunosuppressive, anti-proliferative and free radical scavenging effects. This agent also increases glucose utilization by enhancing hepatocyte glycogen synthesis, resulting in the lowering of plasma glucose. (NCI04)
C28954	DAB	Retired_Concepts	DAB|4-Dimethylaminoazobenzene|N,N-Dimethyl-4-(phenylazo)benzenamine
C28955	Dacplatinum	Platinum_Compound	Dacplatinum|(4-carboxyphthalato)(1,2-diaminocyclohexane)-platinum(II)|DACCP	A second-generation platinum analog with potential antineoplastic activity.  Dacplatinum alkylates DNA at the N-7 position of guanine, thereby producing DNA interstrand crosslinks and DNA strand breaks, and inhibiting DNA replication. (NCI04)
C28958	Diamorphine_Hydrochloride	Opioid|Substance_of_Abuse	Diamorphine Hydrochloride|Diamorphine HCl	The hydrochloride salt of a diacetyl derivative of the opiate morphine, a naturally occurring alkaloid extracted from the seedpod of the Asian poppy (Papaver sp.).  Once administered, diamorphine (or diacetylmorphine) is rapidly hydrolyzed to 6-monoacetylmorphine (6-MAM) and then to the end-product morphine which binds to opiate receptors located throughout the mammalian nervous and gastrointestinal systems.  Inducing a potent analgesia, the use of diamoprhine is often escalated due to a tolerance effect, resulting in abuse that is associated with fatal overdose, abortion, venous sclerosis, and opportunistic infections, among other adverse effects. (NCI04)
C28959	Dichloroallyl_Lawsone	Dihydroorotate_Dehydrogenase_Inhibitor|Pyrimidine_Antagonist	Dichloroallyl Lawsone	A triazine derivative with antineoplastic activity.  Dichloroallyl lawsone inhibits mitochondrial dihydroorotate dehydrogenase (DHOD), an enzyme that catalyzes the only redox step in de novo pyrimidine biosynthesis, and nucleotide (RNA and DNA) biosynthesis. (NCI04)
C28961	Diluent_12	Drug_Vehicle	Diluent 12
C28962	Diluent_for_BCG-Tice	Sodium_Chloride_0_9	Diluent for BCG-Tice
C28963	Diluent_for_Hepsulfam	Drug_Vehicle	Diluent for Hepsulfam
C28966	Anti-Dopamine-b-Hydroxylase_Monoclonal_Antibody-Saporin	Immunotoxin	Anti-Dopamine-b-Hydroxylase Monoclonal Antibody-Saporin|DSAP
C28967	Dacarbazine_Mesna	Chemotherapy_Regimen	Dacarbazine/Mesna|DTIC/Mesna
C28968	Deodorized_Tincture_of_Opium	Opium_Tincture	Deodorized Tincture of Opium|DTO
C28969	Dtpace	Chemotherapy_Regimen	Cisplatin/Cyclophosphamide/Dexamethasone/Doxorubicin/Etoposide/Thalidomide|Dtpace
C28970	Dakins_Solution	Topical_Anti-Infective_Agent	Dakins Solution|Aqueous Solution of Sodium Hypochlorite|Dakins
C28971	Danaparoid_Sodium	Low_Molecular_Weight_Heparin	Danaparoid Sodium|Orgaran
C28973	Dayquil	Cough_and_Cold_Preparation	Dayquil
C28974	Delavirdine_Mesylate	Reverse_Transcriptase_Inhibitor	Delavirdine Mesylate|DELAVIRDINE MESYLATE|Rescriptor|U-90|U90	A synthetic, non-nucleoside reverse transcriptase (RT) inhibitor with antiviral properties.  Delavirdine binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication.  In combination with at least two other anti-retroviral drugs, this agent has been shown to reduce HIV viral load and increase CD4 leukocyte counts in the majority of patients.  As an inhibitor of the cytochrome P450 system, delavirdine may result in increased serum levels of those co-administered protease inhibitors metabolized by the cytochrome P450 system. (NCI04)
C28975	Demeclocycline_Hydrochloride	Tetracycline_Antibiotic	Demeclocycline Hydrochloride|7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride|DEMECLOCYCLINE HYDROCHLORIDE|Declomycin|Demeclocycline HCl	A tetracycline derivative exhibiting antimicrobial activity.  Demeclocycline hydrochloride blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis.  In addition, this agent inhibits ADH-induced water reabsorption in the kidneys, thereby causing water diuresis. (NCI)
C28976	Dendritic_Cell_Therapy	Biological_Cancer_Immunotherapy	Dendritic Cell Therapy
C28977	Deniluekin	Retired_Concepts	Deniluekin
C28978	Deoxythioguanosine	Retired_Concepts	Deoxythioguanosine
C28979	Desipramine_Hydrochloride	Antidepressant_Agent	Desipramine Hydrochloride|DESIPRAMINE HYDROCHLORIDE|Desipramine HCl
C28980	Devils_Foot-Jambul	Chemotherapy_Regimen	Devil's Foot/Jambul	An herbal combination of two plants, devil's claw (Harpagophytum procumbens) and jambul (Eugenia jambolana) that may be administered both orally and topically in various formulations.  Devil's claw has been used as a tonic, as a hypoglycemic, to cleanse the lymph system, and in the treatment of arthritis and rheumatism.  This agent may have anti-inflammatory and analgesic properties, possibly due to the presence of antioxidants, phenols, tannins, triterpenoids and volatile oils.  Jambul seeds and fruits have important carminative and astringent properties and may reduce blood sugar levels. This agent contains glucosides, jamboline and ellagic acid which may check the conversion of starch into sugar. (NCI04)
C28981	Dextroamphetamine	Substance_of_Abuse	Dextroamphetamine|Dexedrine	A synthetic substance related to natural sympathomimetic amines and the synthetic agent amphetamine. In the central nervous system (CNS), dextroamphetamine induces the release of dopamine within the mesocorticolimbic system, a major component of the brain reward system, resulting in measurable behavioral changes such as euphoria. As a CNS stimulant, this agent may increase blood pressure and reduce appetite. Similar to other amphetamines, dextroamphetamine has a high potential for abuse, dependence, and addiction if used in large doses over extended periods of time. (NCI04)
C28982	Diazepam	Benzodiazepine	Diazepam|7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one|DIAZEPAM|Valium
C28983	Dibromannitol	Retired_Concepts	Dibromannitol
C28984	Dibucaine	Anesthetic_Agent	Dibucaine
C28985	Diclofenac	Cyclooxygenase_Inhibitor	Diclofenac|2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid	A nonsteroidal benzeneacetic acid derivative with anti-inflammatory activity.  As a nonsteroidal anti-inflammatory drug (NSAID), diclofenac binds and chelates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory-proprostaglandins.  This agent also may inhibit COX-2-mediated tumor angiogenesis.  When inhibiting COX-2, diclofenac may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects.  This agent may be more active against COX-2 than several other carboxylic acid-containing NSAIDs. (NCI04)
C28986	Dicloxacillin	Penicillin_Antibiotic	Dicloxacillin|3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolylpenicillin|DICLOXACILLIN
C28987	Dicyclomine_Hydrochloride	Antispasmotic_Agent	Dicyclomine Hydrochloride|Bentyl|DICYCLOMINE HYDROCHLORIDE|Dicyclomine HCl
C28989	Adapalene	Retinoic_Acid_Agent	Adapalene|6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid|6-(4-Methoxy-3-tricyclo(3.3.1.13,7)dec-1-ylphenyl)-2-naphthalenecarboxylic Acid|ADAPALENE|CD271|Differin	A topical retinoid-like compound, chemically similar to vitamin A.  Although the exact mechanism of action is unknown, adapalene binds to specific retinoic acid receptors in the nucleus, leading to specific gene expression.  This agent stimulates skin growth through modulation of cellular differentiation, inflammatory processes and keratinization of follicular epithelial cells.  Adapalene may increase dermal sensitivity to ultraviolet radiation. (NCI04)
C28990	Digoxin	Unclassified_Chemotherapy_Agent	Digoxin|DIGOXIN|Lanoxin	A cardiac glycoside. Digoxin inhibits the sodium potassium adenosine triphosphatase (ATPase) pump, thereby increasing intracellular calcium and enhancing cardiac contractility.  This agent also acts directly on the atrioventricular node to suppress conduction, thereby slowing conduction velocity.  Apparently due to its effects on intracellular calcium concentrations, digoxin induces apoptosis of tumor cells via a pathway involving mitochondrial cytochrome c and caspases 8 and 3. (NCI04)
C28991	Diluent_for_161-180_ESO-1_Peptide	Drug_Vehicle	Diluent for (161-180)ESO-1 Peptide|0.1% v/v TFA in Water for Injection|Diluent for (161-180)ESO-1 Peptide (0.1% v/v TFA in Water for Injection)	A water-based solution with 0.1 % v/v trifluoro acetic acid (TFA) for the preparation and use of the peptide ESO-1. (NCI04)
C28992	Dimenhydrinate	Antiemetic_Agent	Dimenhydrinate|DIMENHYDRINATE|Dramamine
C28993	Dimetapp	Cough_and_Cold_Preparation	Dimetapp
C28994	Diphencyprone	Immunostimulant	Diphencyprone|DPCP|Diphenylcyclopropenone
C28995	Diphenoxylate	Antidiarrheal_Agent	Diphenoxylate Hydrochloride|DIPHENOXYLATE HYDROCHLORIDE|Diphenoxylate
C28996	Divalproex	Anticonvulsant_Agent	Divalproex|Depakote|Depakote ER
C28997	Dobutamine_Hydrochloride	Adrenergic_Agent	Dobutamine Hydrochloride|DOBUTAMINE HYDROCHLORIDE|Dobutamine HCl|Dobutrex
C28998	Docetaxel_flavopiradol	Retired_Concepts	Docetaxel/flavopiradol
C28999	Docusate_Calcium	Stool_Softener	Docusate Calcium|Surfak
C29000	Docusate_Sodium	Stool_Softener	Docusate Sodium|Colace
C29001	Domeboro_Solution	Astringent	Domeboro Solution
C29002	Donnatol	Antispasmotic_Agent	Donnatol
C29003	Dorzolamide	Carbonic_Anhydrase_Inhibitor	Dorzolamide Hydrochloride|DORZOLAMIDE HYDROCHLORIDE|Dorzolamide	An inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions.  Distributed throughout many cells and tissues, various carbonic anhydrases play important roles in mineral and metabolic homeostasis. (NCI04)
C29004	Dorzolamide_Sodium	Dorzolamide	Dorzolamide Sodium|Trusopt	The sodium salt of Dorzolamide.  An inhibitor of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions.  Distributed throughout many cells and tissues, various carbonic anhydrases play important roles in mineral and metabolic homeostasis. (NCI04)
C29005	Doxazosin_Mesylate	Alpha-adrenergic_Agonist	Doxazosin Mesylate|Cardura|DOXAZOSIN MESYLATE
C29006	Doxepin_Hydrochloride	Antidepressant_Agent	Doxepin Hydrochloride|Adapin|Doxepin HCl|Sinequan
C29007	Doxycline_Hyclate	Doxycycline	Doxycycline Hyclate|DOXYCYCLINE HYCLATE|Doxycline Hyclate	Doxycycline in the monohydrate complex with ethanol form exhibiting antimicrobial activity.  Doxycycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis.  In addition, this agent has exhibited inhibition of collagenase activity. (NCI)
C29008	Doxycycline_Calcium	Doxycycline	Doxycycline Calcium	The calcium salt form of doxycycline exhibiting antimicrobial activity.  Doxycycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis.  In addition, this agent has exhibited inhibition of collagenase activity. (NCI)
C29009	Doxycycline_Chloride	Retired_Concepts	Doxycycline Chloride
C29010	Doxycycline_Hydrochloride	Doxycycline	Doxycycline Hydrochloride|Doxycycline Chloride|Doxycycline HCl	The hydrochloride salt form of doxycycline exhibiting antimicrobial activity.  Doxycycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis.  In addition, this agent has exhibited inhibition of collagenase activity. (NCI)
C29011	Doxycycline_Monohydrate	Retired_Concepts	Doxycycline Monohydrate	The monohydrate form of doxycycline exhibiting antimicrobial activity.  Doxycycline blocks binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis.  In addition, this agent has exhibited inhibition of collagenase activity. (NCI)
C29012	Drops	Drug_Vehicle	Drops	A popular term for a medicine taken in doses measured by drops. (from On-line Medical Dictionary)
C29013	DuraVent_DA	Cough_and_Cold_Preparation	DuraVent DA|DuraVent/DA
C29014	Duratec	Unclassified_Drugs_and_Chemicals	Duratec
C29015	Dyclonine	Anesthetic_Agent	Dyclonine|Cepacol|Sucrets
C29017	EGFRvIII_Peptide	Vaccine_Antigen	EGFRvIII Peptide	A synthetic peptide sequence derived from the tumor specific mutant variant of epidermal growth factor receptor EGFRvIII originally found in glioblastoma multiforme, caused by the deletion of exons 2-7. Unlike wild-type EGFR, EGFRvIII is a dominant oncogene that can directly lead to cancer. EGFRvIII is expressed in multiple cancer types including breast, ovarian, and metastatic prostate cancers, and other types of solid tumors due to alternative splicing; has not been observed in normal human tissues. Vaccination with EGFRvIII peptide stimulates the host immune system to mount a cytotoxic T lymphocyte response against tumor cells positive for EGFRvIII, resulting in decreased tumor growth. (NCI04)
C29018	Emetine_Hydrochloride	Protein_Synthesis_Inhibitor	Emetine Hydrochloride|Eemetine HCl	The chloride salt of a white crystalline bitter alkaloid isolated from the root of the plant Psychotria Ipecacuanha (ipecac root) and other plants with antiemetic and anthelminthic properties.  Emetine inhibits protein synthesis in eukaryotic (but not prokaryotic) cells by irreversibly blocking ribosome movement along the mRNA strand and inhibits DNA replication in the early S phase of the cell cycle. (NCI04)
C29019	Emfolin_Sodium	Dihydrofolate_Reductase_Inhibitor|Folate_Antagonist	Emfolin Sodium|Emofolin Sodium|Methyltetrahydrohomofolate	The sodium salt of a synthetic antimetabolite analogue of folate with antineoplastic activity.  Emfolin sodium competes for the folate binding site of the enzyme dihydrofolate reductase, resulting in inhibition of tetrahydrofolate synthesis, depletion of nucleotide pools, and inhibition of DNA, RNA and protein synthesis. (NCI04)
C29020	EQUILIN	Estrogen	Equilin|3-Hydroxyestra-1,3,5(10),7-tetraen-17-one	A naturally occurring steroid with estrogenic activity obtained from the urine of pregnant mares.
C29022	Ethidium_Chloride	Intercalating_Agent	Ethidium Chloride|3,8-Diamino-5-ethyl-6-phenylphenanthridinium Chloride|Homidium Chloride|Novidium Chloride	The chloride salt of ethidium (a fluorochrome), Ethidium Chloride intercalates within double-stranded nucleic acids, particularly DNA. In molecular biology, the bromide salt of ethidium is used to detect and visualize DNA after electrophoresis or in cytochemical preparations. In veterinary pharmacology, it is used as a trypanosomicide. Ethidium bromide and chloride are toxic substances and potent noncompetitive antagonists of the nicotinic acetylcholine receptor. (NCI04)
C29023	Etiocholanolone	Androgen|Immunostimulant	Etiocholanolone	A 17-ketosteroid which excreted in the urine as a metabolite of steroid hormones. The most common form of etiocholanolone present in the urine is the sulfate salt. This agent, also known as 5-isoandrosterone, may be used to evaluate adrenal cortex function, bone marrow performance and, in neoplastic disease, for immunostimulation.  (NCI04)
C29024	EWS-FLI1_Type_4	Antisense_Agent	EWS/FLI 1 Type 4|EWS/FLI 1 (Type 4)	The type 4 form of EWS/FLI-1, an oncogenic fusion gene found in Ewing's sarcoma and primitive neuro-ectodermal tumor (PNET). Resulting from a t(11;22) chromosomal translocation, EWS/FLI 1 appears to play an integral role in the development of Ewing's sarcoma and PNET; the type 4 form of this gene has been shown to transform non-neoplastic cells.  EWS/FLI 1 type 4 represents a potential target for antisense oligonucleotide therapy of Ewing's sarcoma and PNET. (NCI04)
C29025	EWS-FLI1_Type_8	Antisense_Agent	EWS/FLI 1 Type 8|EWS/FLI 1 (Type 8)|Sarcoma-specific Peptide SSSYGQQN/PYQILGPTSS	An antisense oligonucleotide that targets the type 8 form of EWS/FLI-1, an oncogenic fusion gene found in Ewing's sarcoma and primitive neuro-ectodermal tumor that results from a t(11;22) chromosomal translocation.  EWS/FLI 1 type 8 antisense oligonucleotide inhibits the expression of the EWS/FLI 1 type 8 gene and/or the translation of EWS/FLI 1 type 8 mRNA, thereby down-regulating the abnormal transcription factor and inhibiting tumor cell growth and tumorigenicity. (NCI04)
C29026	Echinacea	Immunostimulant	Echinacea
C29027	Efavirenz	Reverse_Transcriptase_Inhibitor	Efavirenz|DMP-266|EFAVIRENZ|L743726|Sustiva	A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral properties.  Efavirenz binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication.  In combination with other antiretroviral drugs, this agent has been shown to significantly reduce HIV viral loads, therefore retarding or preventing damage to the immune system, and reducing the risk of developing AIDS.  Efavirenz induces activity of the cytochrome P450 system, thereby accelerating its own metabolism. (NCI04)
C29028	Entex	Cough_and_Cold_Preparation	Entex
C29029	Ergocalciferol	Vitamin_D	Ergocalciferol|ERGOCALCIFEROL|Vitamin D	Vitamin D2, a fat-soluble vitamin important for many biochemical processes including the absorption and metabolism of calcium and phosphorus.  In vivo, ergocalciferol is formed after sun (ultraviolet) irradiation of plant-derived ergosterol, another form of vitamin D. Ergocalciferol is the form of vitamin D usually found in vitamin supplements. (NCI04)
C29030	Small_Inducible_Cytokine-B13	Alpha_Chemokine	Small Inducible Cytokine B13|ANGIE|B Cell-Attracting Chemokine 1|B Lymphocyte Chemoattractant|B-Cell Chemoattractant|B-Cell-Homing Chemokine|BCA-1|Burkitt's Lymphoma Receptor-1 Ligand|CXC Chemokine BLC|CXCL13|Chemokine (C-X-C Motif) Ligand 13|Small Inducible Cytokine B Subfamily (Cys-X-Cys Motif), Member 13	Expressed in liver, spleen, lymph node, Peyer's patches, appendix, stomach, salivary gland, mammary gland, and fetal spleen by human CXCL13 Gene (Intercrine Alpha/Chemokine CXC Family), secreted 109-aa 13-kD (precursor) Small Inducible Cytokine B13 binds to BLR1/CXCR5 and promotes migration and chemotaxis of B lymphocytes expressing BLR-1. It may function in B lymphocyte homing to follicles. (NCI)
C29031	Small_Inducible_Cytokine-B14	Alpha_Chemokine	Small Inducible Cytokine B14|BRAK|CXC Chemokine in Breast and Kidney|CXCL14|Chemokine (C-X-C Motif) Ligand 14|Chemokine BRAK|Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 14	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas by human CXCL14 Gene (Intercrine Alpha/Chemokine CXC Family), secreted immunoregulatory 99-aa 12-kD (precursor) Small Inducible Cytokine B14 is chemotactic for monocytes and likely involved in monocyte-derived macrophage homeostasis.  (NCI)
C29032	Esomeprazole_Magnesium	Proton_Pump_Inhibitor	Esomeprazole Magnesium
C29033	Ethambutol_Hydrochloride	Antitubercular_Agent	Ethambutol Hydrochloride|ETHAMBUTOL HYDROCHLORIDE|Ethambutol HCl|Myambutol
C29034	Ethinyl_Estradiol-Levonorgestrel	Oral_Contraceptive	Ethinyl Estradiol/Levonorgestrel|Ethinyl Estradiol/Levonorgestr	A combination of two steroid sex hormones, an estrogen and a progestin, used for contraceptive purposes.  Estradiol, the endogenous counterpart of ethinyl estradiol (EE), is the principal, most potent estrogen hormone produced by the ovaries and is vital to the maintenance of fertility and secondary sexual characteristics in females.  Levonorgestrel is a synthetic progestogen.  This drug combination prevents or delays ovulation and causes a variety of hormonal changes.  Ethinyl estradiol inhibits the release of follicle stimulating hormone (FSH), thus suppressing the development of ovarian follicle; levonorgestrel inhibits the release of luteinizing hormone (LH), thus preventing ovulation.  This combination of agents alters the endometrium in such a way as to discourage implantation. (NCI04)
C29035	Ethinyl_Estradiol-Norethindrone	Oral_Contraceptive	Ethinyl Estradiol/Norethindrone|Ethinyl Estradiol/Norethindron	A combination of two steroid sex hormones, an estrogen and a progestin, used for contraceptive purposes.  Estradiol, the endogenous counterpart of ethinyl estradiol (EE), is the principal, most potent estrogen hormone produced by the ovaries and is vital to the maintenance of fertility and secondary sexual characteristics in females.  Norethindrone is a synthetic progestogen.  This drug combination prevents or delays ovulation and causes a variety of hormonal changes.  Ethinyl estradiol inhibits the release of follicle stimulating hormone (FSH), thus suppressing the development of ovarian follicle; norethindrone levonorgestrel inhibits the release of luteinizing hormone (LH), thus preventing ovulation.  This combination of agents alters the endometrium in such a way as to discourage implantation. (NCI04)
C29036	Etretinate	Retinoic_Acid_Agent	Etretinate|(2E,4E,6E,8E)-9-(4-Methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic Acid, Ethyl Ester|Ethyl-all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate|Ro 10-9359|Tigason	A synthetic oral retinoid that is a prodrug of acitretin.  Etretinate activates retinoid receptors, causing an induction of cell differentiation, inhibition of cell proliferation, and inhibition of tissue infiltration by inflammatory cells.  Etretinate is no longer commercially available in the U.S. due to the extended potential for teratogenic effects related to its long half-life. (NCI04)
C29037	Ex-Lax	Laxative	Ex-Lax
C29038	Excedrin	Analgesic_Preparation	Excedrin
C29039	FDG	Retired_Concepts	FDG
C29040	FGF-5_172-176_217-220_Peptide	Vaccine_Antigen	FGF-5:172-176 / 217-220 Peptide	A naturally occurring 9-residue peptide of fibroblast growth factor 5 (FGF-5). Recognized by tumor infiltrating cytotoxic T lymphocytes originally isolated from a renal cell carcinoma that overexpressed FGF-5, FGF-5:172-176/217-220 peptide activates various cytotoxic CD8 lymphocytes in an HLA-restricted manner.  Overexpressed in several cancer cell lines, FGF-5 is a tumor-associated antigen that may be useful in cancer immunotherapy. (NCI04)
C29042	Fluorodopan	Nitrosourea_Compound	Fluorodopan	An alkylating agent with potential antineoplastic activity.  Fluorodopan alkylates DNA at the N7 position of guanine.  Alkylating agents exert cytotoxic and, in some cases, chemotherapeutic effects by transferring alkyl groups to DNA, thereby damaging DNA and interfering with DNA replication and cell division. (NCI04)
C29043	Fluorotestosterone	Therapeutic_Androgen	Fluorotestosterone|U-11207	A synthetic nonaromatizable androgen analog of testosterone.  Fluorotestosterone (6 alpha-fluorotestosterone) binds to and activates specific nuclear receptors inhibits and is equipotent to testosterone. (NCI04)
C29044	Famciclovir	Nucleic_Acid_Synthesis_Inhibitor	Famciclovir|FAMCICLOVIR|Famvir	A diacetyl 6-deoxy prodrug analog of the antiviral agent penciclovir.  Orally administered, famciclovir in vivo is converted to penciclovir triphosphate, which is active against the Herpes viruses, including herpes simplex 1 and 2 and varicella-zoster.  This agent inhibits the replication of viral DNA by interfering competitively with DNA polymerase. (NCI04)
C29045	Famotidine	Histamine-2_Receptor_Antagonist	Famotidine|Pepcid|Pepcid AC
C29046	Felodipine	Calcium_Channel_Blocker	Felodipine|FELODIPINE|Plendil	A dihydropyridine calcium channel blocking agent. Felodipine inhibits the influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
C29047	Fenofibrate	Anti-lipidemic_Agent	Fenofibrate|FENOFIBRATE|Tricor
C29048	Ferrous_Gluconate	Nutritional_Supplement	Ferrous Gluconate	A form of mineral iron for oral administration, Ferrous Gluconate is absorbed in the stomach and small intestine and combines with apoferritin to form ferritin, which is stored in the liver, spleen, red bone marrow, and intestinal mucosa. Important in transport of oxygen by hemoglobin to the tissues, iron is also found in myoglobin, transferrin, and ferritin, and is as a component of many enzymes such as catalase, peroxidase, and cytochromes. (NCI04)
C29049	Ferrous_Sulfate	Nutritional_Supplement	Ferrous Sulfate|Iron(II) Sulfate	A sulfate salt of mineral iron formulated for oral administration and used as a dietary supplement, Ferrous Sulfate is absorbed in the stomach and small intestine and combines with apoferritin to form ferritin, which is stored in the liver, spleen, red bone marrow, and intestinal mucosa. Important in transport of oxygen by hemoglobin to the tissues, iron is also found in myoglobin, transferrin, and ferritin, and is as a component of many enzymes such as catalase, peroxidase, and cytochromes. (NCI04)
C29050	Fexofenadine_Hydrochloride	Histamine-1_Receptor_Antagonist	Fexofenadine Hydrochloride|Allegra|FEXOFENADINE HYDROCHLORIDE|Fexofenadine HCl
C29051	Fioricet	Analgesic_Preparation	Fioricet
C29052	Fleets_Phospho-Soda	Laxative_Preparation	Fleets Phospho-Soda
C29053	Flucinolone	Therapeutic_Glucocorticoid	Flucinolone
C29054	Flunisolide	Therapeutic_Glucocorticoid	Flunisolide|FLUNISOLIDE
C29055	Fluocinolone_Acetonide	Therapeutic_Glucocorticoid	Fluocinolone Acetonide|(6alpha,11beta,16alpha)-6,9-Difluoro-11,21-dihydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione|FLUOCINOLONE ACETONIDE
C29056	Fluocinonide	Therapeutic_Glucocorticoid	Fluocinonide|(6alpha,11beta,16alpha)-21-(Acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione|Lidex
C29058	Fluorometholone	Therapeutic_Glucocorticoid	Fluorometholone|FLUOROMETHOLONE
C29059	Fluoxamine	Retired_Concepts	Fluoxamine|Luvox
C29060	Flurazepam	Benzodiazepine	Flurazepam Hydrochloride|Dalmane|FLURAZEPAM HYDROCHLORIDE|Flurazepam
C29061	Fluticasone_Propionate	Therapeutic_Glucocorticoid	Fluticasone Propionate|(6alpha,11beta,16alpha,17alpha)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic Acid, S-(Fluoromethyl) Ester|FLUTICASONE PROPIONATE|Flonase|Flovent
C29062	Fluvastatin_Sodium	HMG-CoA_Reductase_Inhibitor	Fluvastatin Sodium|(3R,5S,6E)-(+/-)-7-(3-(4-Fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl)-3,5-dihydroxy-6-heptenoic Acid|FLUVASTATIN SODIUM|Lescol	A synthetic lipid-lowering agent.  Formulated as as a sodium salt, fluvastatin sodium competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis.  Fluvastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by the suppression of MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)
C29063	Fluvoxamine_Maleate	Antidepressant_Agent	Fluvoxamine Maleate|Fluoxamine
C29065	FrSh61_MEA_VHL33	Von_Hippel-Lindau_Peptide_Vaccine	FrSh61 (MEA) VHL33	A peptide derived from the tumor suppressor protein Von Hippel-Lindau (VHL). The VHL gene produces two proteins; the more abundant protein is VHLp18(MEA) (where MEA stands for three amino acids, Met-Glu-Ala). VHLp18 (MEA) peptides share biological properties with native VHL proteins and have been shown to suppress tumorigenesis in animal models of VHL-deficient tumorigenesis. (NCI04)
C29066	Gamma_Interferon-SCH	Retired_Concepts	Gamma Interferon-SCH
C29067	GM-CSF_DNA	Transduction_Gene	GM-CSF DNA	DNA that encodes granulocyte-macrophage colony stimulating factor (GM-CSF).  GM-CSF enhances the host immune response to poorly immunogenic tumors, possibly by activating T-cell and macrophage anti-tumor responses, and, so, decreasing tumor growth. (NCI04)
C29068	gp100_Vaccinia_Vaccine	Vaccinia_Vaccine	gp100 Vaccinia Vaccine|GP100 Vaccinia Vaccine	A cancer vaccine consisting of a recombinant vaccinia virus encoding the gp100 melanoma-melanocyte antigen. gp100 human antigen is a wild-type self-antigen expressed by melanocytes, pigmented retinal cells and most melanomas. (NCI04)
C29069	Garlic_Extract	Nutritional_Supplement	Garlic Extract|Allium sativum Extract|CCRIS 7640|EINECS 232-371-1	The alcoholic extract of the bulb or whole garlic plant Allium sativum (Liliaceae) with potential antineoplastic activity. The garlic plant has long been considered a beneficial plant for health and has been used as an antihelmintic, a rubefacient, an anti-infective, and an antihypertensive. Fresh or aged, garlic extracts contain compounds such as diallyl and allyl propyl disulfides with potent antioxidant, cholesterol-lowering properties; regular ingestion may be preventative for atherosclerosis and cardiovascular diseases. (NCI04)
C29070	Gatifloxacin	Quinolone_Antibiotic	Gatifloxacin|GATIFLOXACIN|Tequin
C29071	Gemfibrozil	Anti-lipidemic_Agent	Gemfibrozil|GEMFIBROZIL|Lopid
C29072	Gingkgo	Antioxidant	Ginkgo|Gingkgo|Ginkgo biloba	A substance derived from the plant Ginkgo biloba.  Ginkgo biloba leaf extract contains potent anti-oxidants and substances believed to improve blood flow to the brain and peripheral tissues.  Ginkgo biloba exocarp polysaccharides (GBEP) can inhibit proliferation and induce apoptosis and differentiation of tumor cells.  As a medicinal herb, ginkgo requires standardization for medicinal use; typically, a 50:1 extract of ginkgo leaf is used in ginkgo supplements. (NCI04)
C29073	Glimepiride	Anti-diabetic_Agent	Glimepiride|Amaryl
C29074	Glipizide	Anti-diabetic_Agent	Glipizide|GLIPIZIDE|Glucotrol
C29075	Glucosamine_Sulfate	Nutritional_Supplement	Glucosamine Sulfate	An amino sugar (2-amino, 2-deoxyglucose) in cell membranes, Glucosamine Sulfate is believed to play a role in cartilage formation and repair. Long-term glucosamine sulfate treatment retards progression of knee osteoarthritis; the mechanism appears to involve glucosamine's role as an essential substrate for glycosaminoglycans and hyaluronic acid, needed for formation of the joint proteoglycan structural matrix. (NCI04)
C29076	Glyburide	Anti-diabetic_Agent	Glyburide|GLYBURIDE|Micronase
C29077	Glycerin	Drug_Vehicle	Glycerin|GLYCERIN
C29078	Glycopyrrolate	Anti-ulcer_Agent	Glycopyrrolate|Robinul|Robinul Forte
C29079	Glyoktyl	Laxative_Preparation	Glyoktyl|Glycerin/Docusate	A Danish brand name for a laxative product containing glycerin and docusate sodium.  As a hyperosmotic laxative, glycerin draws water into the bowel from surrounding tissues, thereby softening the stool and increasing bowel action.  Docusate sodium acts as a surface-active agent (emollient) that promotes the mixing of intestinal liquid and dry stool. (NCI04)
C29080	GoLYTELY	Laxative_Preparation	GoLYTELY|Go LYTELY
C29081	Guaifenesin	Expectorant	Guaifenesin|GUAIFENESIN|Humibid|Mucinex|Robitussin
C29082	Guaifenesin_Codeine	Cough_and_Cold_Preparation	Guaifenesin/Codeine|Robitussin AC
C29083	Guaifenisin-DM	Cough_and_Cold_Preparation	Guaifenisin-DM|Robitussin DM
C29084	Guaifenisin_Pseudoephedrine	Cough_and_Cold_Preparation	Guaifenisin/Pseudoephedrine
C29085	HIV_Peptide_Vaccine	HIV_Vaccine	HIV Peptide Vaccine	A vaccine containing one or more peptides derived from the human immunodeficiency virus (HIV). As a vaccine antigen, an HIV peptide may stimulate the host immune response against HIV, thereby preventing or treating HIV infection. (NCI04)
C29086	HIVgP160_Vaccine	HIV_Peptide_Vaccine	HIVgP160 Vaccine|HIVGP160 Vaccine	A synthetic HIV vaccine based on a recombinant canary pox virus vector expressing the human immunodeficiency virus (HIV) glycoprotein gp160.  HIVgP160 vaccine has been used to generate in vivo primary T lymphocyte response against HIV antigens. (NCI04)
C29088	HPV_16_L1-VLP	Human_Papilloma_Virus_Vaccine	HPV 16 L1-VLP	A vaccine consisting of human papillomavirus-derived noninfectious virus-like particles (VLPs), containing the L1 major capsid protein.  Vaccination with HPV 16 L1-VLP results in increases in T cell-proliferative response to HPV 16 L1-VLP, as well as significant increases in cytokine (interferon-gamma, interleukin-5 and -10) responses to L1 VLP.  This agent may reduce the incidence of persistent HPV-16 infection, which may be responsible for half of all cases of cervical cancer including high-grade cervical intraepithelial neoplasia. (NCI04)
C29089	Human_MOAB_LICO_28a32	Monoclonal_Antibody	Human MOAB LICO 28a32	A human monoclonal immunoglobulin M (IgM) antibody with potential antineoplastic activity.  Human MOAB LICO 28a32 binds to the colon tumor-associated antigen 28A32 (CTAA 28A32) found on the cell surface and in the cytoplasm of colon carcinoma cells. (NCI04)
C29090	Hepatitis_A_Vaccine	Inactivated_Vaccine	Hepatitis A Vaccine|Havrix|Vaqta	An inactivated virus vaccine that provides active immunization against hepatitis A virus (HAV).  Immunization with hepatitis A vaccine induces the formation of anti-HAV antibodies which provide protection against hepatitis A infection. (NCI04)
C29091	Hepatitis_B_Vaccine	Recombinant_Viral_Vaccine	Hepatitis B Vaccine	A non-infectious mixture containing recombinant hepatitis B surface antigen (HBsAg) in a liquid vehicle.  Immunization with the hepatitis B vaccine induces the formation of specific anti-hepatitis B antibodies and an active immunity against hepatitis B infection. (NCI04)
C29092	Hexylresorcinol	Topical_Anti-Infective_Agent	Hexylresorcinol
C29093	Homatropine_Hydrobromide	Mydriatic_Agent	Homatropine Hydrobromide|Isopto Homatropine	The bromide salt of homatropine, a synthetic alkaloid derivative of atropine (Atropa belladonna) used in ophthalmologic procedures.  Although less potent, homatropine hydrobromide possesses parasympatholytic properties similar to those of atropine. Inducing mydriasis and cycloplegia, this agent relaxes the ciliary muscle and sphincter muscles of the eye; relaxation of these muscles prevents the lens from focusing and widens the pupil. (NCI04)
C29095	HuCC49deltaCH2-PA-DOTA	Conjugated_Mononclonal_Antibody_CC49	HuCC49deltaCH2-PA-DOTA|HuCC49DCH2-PA-DOTA
C29096	Hycaptmn	Retired_Concepts	Hycaptmn
C29097	Hydrazine	Anticachexia_Agent|Monoamine_Oxidase_Inhibitor	Hydrazine	A highly reactive base and reducing agent used in many industrial and medical applications.  In biological applications, hydrazine and its derivatives exhibit antidepressant properties by inhibiting monoamine oxidase (MAO), an enzyme that catalyzes the deamination and inactivation of certain stimulatory neurotransmitters such as norepinephrine and dopamine.  In psychiatry, the use of hydrazine derivatives is limited due to the emergence of the tricyclic antidepressants. (NCI04)
C29098	Hydrochlorothiazide	Diuretic	Hydrochlorothiazide|6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide|HYDROCHLOROTHIAZIDE|Hydrodiuril
C29099	Hydrocodone	Opioid	Hydrocodone Bitartrate|HYDROCODONE BITARTRATE|Hycodan|Hydrocodone
C29100	Hydrocodone_Acetaminophen	Analgesic_Preparation	Hydrocodone/Acetaminophen|Lorcet|Vicodin
C29101	Hydroxychloroquine_Sulfate	Hydroxychloroquine	Hydroxychloroquine Sulfate|HYDROXYCHLOROQUINE SULFATE|Plaquenil	A synthetic derivative of quinolyl with chemotherapeutic and antibiotic properties, Hydroxychloroquine Sulfate acts against erythrocytic malarial parasites (Plasmodium vivax, ovale, and malariae) by concentrating in food vacuoles. It inhibits plasmodial heme polymerase and acts through other unknown mechanisms. Hydroxychloroquine also has anti-inflammatory properties and is used in the treatment of rheumatoid arthritis and lupus erythematosus. (NCI04)
C29102	Hydroxypropyl_Methycellulose_D	Drug_Vehicle	Hydroxypropyl Methylcellulose D
C29103	Hydroxyzine	Antiemetic_Agent	Hydroxyzine|Atarax|Vistaril
C29104	Hyoscyamine	Antimuscarinic_Agent	Hyoscyamine Sulfate|Cystospaz-M|HYOSCYAMINE SULFATE|Hyoscyamine|Levsin	A belladonna alkaloid derivative isolated from the plants Hyoscyamus niger and Atropa belladonna exhibiting anticholinergic activity.  Hyoscyamine functions as a non-selective, competitive antagonist of muscarinic receptors, thereby inhibiting parasympathetic effects.  This agent may induce tachycardia, inhibit secretions, and relax smooth muscles. (NCI)
C29105	Hypoxanthine	Purine	Hypoxanthine	A purine-based organic compound in human muscle tissues, Hypoxanthine is formed during purine catabolism as a product of xanthine oxidase action on xanthine, and occasionally is found as a constituent of nucleic acids. The potent anti-inflammatory and cytoprotective effects of purines may be mediated by cell surface adenosine receptors. Hypoxanthine protects against oxidant-induced cell injury by inhibiting activation of nuclear poly(ADP-ribose) polymerase (PARP). (NCI04)
C29106	I131-COL1	Radioimmunoconjugate	I131-COL1	A radioimmunoconjugate consisting of COL-1, a murine monoclonal antibody specific for carcinoembryonic antigen (CEA), linked to a beta- and gamma-emitting radioisotope iodine 131 (I 131)+B151.  I 131 COL-1 binds to tumor cells expressing CEA, delivering beta and gamma particle radiation.
C29107	IV_Fluid	Drug_Vehicle	IV Fluid|Intravenous Fluid	A sterile liquid preparation infused into a vein.  IV fluid is prescribed as a replacement of fluid, electrolytes, calories, vitamins, and other nutritional substances.  In addition, IV fluids are used to administer blood products and medications such as chemotherapy.  Examples of IV fluids include Normal Saline, Ringers Solution, and Lactated Ringers Solution. (NCI)
C29110	Id_Lymph_Skin_Test_Vaccine	Skin_Test	Id Lymph Vaccine Test|Id Lymph Skin Test Vaccine	A test consisting of a lymphoma idiotype (Id)-specific protein conjugated to the immunogen keyhole limpet hemocyanin (KLH).  As a test of innate host delayed-type hypersensitivity (DTH) and host DTH in response to therapeutic vaccination, Id lymph vaccine test is performed intradermally before and after therapeutic vaccination in lymphoma patients treated with Id-specific vaccines. (NCI04)
C29111	Id_MM_Skin_Test_Vaccine	Skin_Test	Id MM Vaccine Test|Id MM Skin Test Vaccine	A test consisting of a myeloma idiotype (Id)-specific protein conjugated to the immunogen keyhole limpet hemocyanin (KLH).  As a test of innate host delayed-type hypersensitivity (DTH) and host DTH in response to therapeutic vaccination, Id MM vaccine test is performed intradermally before and after therapeutic vaccination in multiple myeloma patients treated with Id-specific vaccines. (NCI04)
C29112	Interleukin-2_Anti-Idiotype_Vaccine	Anti-Idiotype_Vaccine	Interleukin-2 Anti-Idiotype Vaccine|Id/IL-2 Vaccine	A vaccine based on anti-idiotype (Id) monoclonal antibodies combined with interleukin-2 (IL-2).  Anti-Id vaccines have been shown to be effective in treatment of B-cell lymphoma in animal models and in clinical trials, resulting in tumor regression; the addition of interleukin-2 (IL-2) may augment the therapeutic effect of anti-Id vaccines. (NCI04)
C29115	Imexon	Unclassified_Chemotherapy_Agent	Imexon	A 2-cyanoaziridine derivative with antitumor activity in multiple myeloma.  Although its mechanism of action is not clearly known, imexon may induce apoptosis via a pathway involving cleaved caspase-3, caspase-9, and/or caspase-8.  Other cytotoxic mechanisms of action of this agent may involve thiol depletion, generation of reactive oxygen species (ROS), and decreases in the mitochondrial membrane potential. (NCI04)
C29116	Imipramine	Antidepressant_Agent	Imipramine Hydrochloride|IMIPRAMINE HYDROCHLORIDE|Imipramine|Tofranil|Tofranil-PM	A synthetic tricyclic derivative, antidepressant Imipramine enhances monoamine neurotransmission in certain areas of the brain. It also induces sedation through histamine 1 receptor blockage; hypotension through beta-adrenergic blockage; and diverse parasympatholytic effects. Imipramine has less sedative effect than other members of its therapeutic family. It is used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. (NCI04)
C29117	Immutol	Nutritional_Supplement	Immutol	A purified Norwegian Beta-Glucan (NBG), extracted from the cell walls of baker's yeast. Used as an immunostimulant in complementary medicine, NBG binds specifically to receptors found on the surface of specialized macrophages, granulocytes and natural killer cells and may stimulate these cells to become more active in engulfing and digesting foreign antigens; NBG also induces the production of cytokines that further augment the host immune response to foreign antigens. Use of this agent may enhance overall resistance to infectious agents and promote wound healing and tissue repair. (NCI04)
C29119	Indapamide	Diuretic	Indapamide|INDAPAMIDE|Lozol	An indole derivative of chlorosulphonamide with antihypertensive activity.  Indapamide reduces vacular hypersensitivity and peripheral and arterial resistance possibly by inhibition of transmembrane ionic influx and stimulation of prostaglandin E2 synthesis.
C29120	Influenza_Vaccine	Retired_Concepts	Influenza Vaccine
C29121	Insulin_70_30	Therapeutic_Insulin	Insulin, 70/30|Humulin 70/30|Novolin 70/30	A mixture of two types of insulin consisting of 70 percent long-acting insulin suspension and 30 percent rapid-acting insulin.  Typically administered twice a day, insulin 70/30 controls postprandial glycemia and allows convenient mealtime dosing. The long-acting insulin component controls blood glucose levels between meals. Endogenous human insulin, a pancreatic hormone composed of two polypeptide chains, is important for the normal metabolism of carbohydrates, proteins and fats; it has anabolic effects on many types of tissues. (NCI04)
C29122	Lente_Insulin	Therapeutic_Insulin	Insulin, Lente|Lente Iletin II	A long-acting crystalline insulin often used in combination with a short-acting insulin in the treatment of diabetes mellitus.  This type of insulin may be derived from porcine or recombinant sources.  Administered once daily, insulin Lente starts to lower blood glucose within 1 to 3 hours after injection and exerts its peak effect 7 to 15 hours after injection.  Endogenous human insulin, a pancreatic hormone composed of two polypeptide chains, is important for the normal metabolism of carbohydrates, proteins and fats; it has anabolic effects on many types of tissues. (NCI04)
C29123	Lispo_Insulin	Therapeutic_Insulin	Insulin, Lispro|Humalog|INSULIN LISPRO RECOMBINANT	A recombinant therapeutic agent which is chemically identical to or similar to endogenous human insulin.  In lispro insulin, the amino acid proline at B-28 and the amino acid lysine at B-29 are reversed, resulting in the rapid dissolution of this insulin to a monomer that is absorbed rapidly after subcutaneous administration.  Lispro insulin is equipotent to human insulin on a molar basis but its effects are faster and of shorter duration.  Endogenous insulin, a pancreatic hormone composed of two polypeptide chains, is important in the normal metabolism of carbohydrates, proteins and fats, promoting glucose utilization and protein synthesis; it has anabolic effects on many types of tissues. (NCI04)
C29124	NPH_Insulin	Therapeutic_Insulin	Insulin, NPH|Humulin N|Novolin N	An intermediate-acting insulin used in the treatment of diabetes mellitus.  Administered once or twice daily, NPH (neutral protamine hagedorn) insulin lowers blood glucose within 1 to 2 hours after administration and exerts a peak effect at 6 to 10 hours.  Endogenous insulin, a pancreatic hormone composed of two polypeptide chains, is important in the normal metabolism of carbohydrates, proteins and fats, promoting glucose utilization and protein synthesis; it has anabolic effects on many types of tissues. (NCI04)
C29125	Regular_Insulin	Therapeutic_Insulin	Insulin, Regular|Humulin R|Novolin R	A short-acting form of insulin.  Regular insulin is obtained from animal or recombinant sources.  The onset of action of regular insulin occurs at 30-90 minutes after injection; its effect lasts for 6 to 8 hours.  Endogenous human insulin, a pancreatic hormone composed of two polypeptide chains, is important for the normal metabolism of carbohydrates, proteins and fats; it has anabolic effects on many types of tissues. (NCI04)
C29126	Ultralente_Insulin	Therapeutic_Insulin	Insulin, Ultralente|Humulin U|Insulin Zinc Injectable Suspension	A long-acting form of crystalline insulin often used in combination with a short-acting insulin in the treatment of diabetes mellitus.  Administered once daily, this type of insulin may be derived from porcine, bovine, or recombinant sources.  Endogenous human insulin, a pancreatic hormone composed of two polypeptide chains, is important for the normal metabolism of carbohydrates, proteins and fats; it has anabolic effects on many types of tissues. (NCI04)
C29127	Iodine-131_Human_Serum_Albumin	Radioimmunoconjugate	Iodine-131 Human Serum Albumin|I 131 HSA|Iodine-131 Human Serum Albumin (HSA)	A synthetic radiopharmaceutical in which human serum albumin (HSA) is radiolabelled with iodine 131.  Upon intravenous injection, iodine-131 human serum albumin is slowly deiodinated in vivo, releasing radioactive iodide that is taken up by thyroid gland.  Iodine-131 primarily emits beta particles and has a half-life of 8 days. (NCI04)
C29128	Ipratropium_Bromide	Bronchodilator	Ipratropium Bromide|Atrovent	A synthetic quaternary ammonium compound related to atropine, an anticholinergic agent.  Ipratropium bromide competitively inhibits cholinergic receptors located in bronchial smooth muscle, thereby decreasing cholinergic activity and ultimately bronchodilation.
C29129	Ipratropium_Albuterol	Asthma_Preparation	Ipratropium/Albuterol|Combivent
C29130	Irbesartan	Antihypertensive_Agent	Irbesartan|Avapro|IRBESARTAN	A nonpeptide angiotensin II antagonist with antihypertensive activity. Irbesartan selectively and competitively blocks the binding of angiotensin II to the angiotensin I receptor. Angiotensin II stimulates aldosterone synthesis and secretion by adrenal cortex, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle. (NCI05)
C29132	Irritumomab_tiuxetan	Retired_Concepts	Irritumomab tiuxetan
C29133	Isoproterenol	Bronchodilator	Isoproterenol Hydrochloride|4-[1-Hydroxy-2-[(1-methylethyl)amino]ethyl]-1,2-benzenediol|ISOPROTERENOL HYDROCHLORIDE|Isoproterenol|Isuprel
C29134	Isosorbide_Dinitrate	Vasodilating_Agent	Isosorbide Dinitrate|ISOSORBIDE DINITRATE|Isordil	The dinitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide dinitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide dinitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05)
C29135	K-RAS_ASP-12_Mutant_Protein	Mutated_Ras_Peptide	K-RAS ASP-12 Mutant Protein	A mutant form of the p21-ras protein transcribed from a mutant form of the oncogene K-ras.  K-Ras is located in the plasma membrane and transduces growth and differentiation signals from activated receptors to protein kinases within the cell.  K-RAS ASP-12 contains a mutation at codon 12 and may be used in cancer immunotherapy. (NCI04)
C29136	K-RAS_ASP-13_Mutant_Protein	Mutated_Ras_Peptide	K-RAS ASP-13 Mutant Protein	A synthetic form of the ras protein containing a point mutation at position 13 (glycine to asparagine). Vaccines using mutant K-ras proteins may be used in the immunotherapy of various cancers that express mutated K-ras proteins. (NCI04)
C29137	K-RAS_GLY-12_Mutant_Protein	Mutated_Ras_Peptide	K-RAS GLY-12 Mutant Protein	A synthetic form of the K-ras protein containing any one of a number of point mutations at position 12 which is normally occupied by glycine (GLY). Vaccines using mutant K-ras proteins may be used in the immunotherapy of various cancers that express mutated K-ras proteins. (NCI04)
C29138	K-RAS_VAL-12_Mutant_Protein	Mutated_Ras_Peptide	K-RAS VAL-12 Mutant Protein	A synthetic form of the K-ras protein containing a point mutation at position 12 (glycine to valine). Vaccines using mutant K-ras proteins may be used in the immunotherapy of various cancers that express mutated K-ras proteins. (NCI04)
C29139	Hydroxypropylcellulose	Drug_Vehicle	Hydroxypropylcellulose|Klucel
C29140	KNI-272	Protease_Inhibitor	KNI-272|4-Thiazolidinecarboxamide, N-(1,1-dimethylethyl)-3- [2-hydroxy-3-[[2-[[(5-isoquinolinyloxy)acetyl]amino]-3- (methylthio)-1-oxopropyl]amino]-1-oxo-4-phenylbutyl]-,[4R-[3[2S*, 3S*(R*)],4R*]]	A synthetic peptide-based antiviral agent.  As a peptidomimetic substrate containing an unnatural amino acid, allophenylnorstatine, KNI-272 selectively binds to and inhibits the human immunodeficiency virus (HIV) 1 and 2 proteases, thereby preventing cleavage of the gag-pol viral polyprotein and resulting in the release of immature, noninfectious virions. (NCI04)
C29141	KRAS_CYS-12_Mutant_Protein	Mutated_Ras_Peptide	KRAS CYS-12 Mutant Protein	A synthetic form of the K-ras protein containing a point mutation at position 12 (glycine to cysteine). Vaccines using mutant K-ras proteins may be used in the immunotherapy of various cancers that express mutated K-ras proteins. (NCI04)
C29142	Ketamine_Hydrochloride	Anesthetic_Agent	Ketamine Hydrochloride|KETAMINE HYDROCHLORIDE|Ketalar|Ketamine HCl	A synthetic nonbarbiturate anesthetic derivative of cyclohexanone, Ketamine Hydrochloride can block NMDA receptors (N-methyl-D-aspartate) and may interact with sigma receptors. Its mechanism of action is not well understood. Ketamine reduces pain perception, causes sedation, and distorts perceptions. It is used for induction of anesthesia. (NCI04)
C29144	Lactobutyrin	Unclassified_Drugs_and_Chemicals	Lactobutyrin
C29146	Labetalol	Antihypertensive_Agent	Labetalol|Labetalol Hydrochloride|Normodyne|Trandate
C29147	Lactase_Enzyme	Nutritional_Supplement	Lactase Enzyme|Lactaid|Lactase	Formulated in various oral forms for use in lactose intolerance, Lactase Enzyme (Lactaid) is a dietary supplement that breaks down lactose (milk sugar) in dairy foods. It prevents gas, diarrhea, and bloating caused by consumption from dairy foods in people that lack the natural lactase enzyme. (NCI04)
C29148	Lactulose	Laxative|Oligosaccharide	Lactulose|Cephulac|Chronulac	A disaccharide (sugar) synthesized from fructose and galactose, Lactulose is used to treat constipation and some liver diseases. Nondigestible in mammals, lactulose passes unabsorbed down to the large intestine where resident bacteria consume it and produce lactic, acetic, and formic acids, which draw fluid into the bowel to soften the stool (laxative effect). Acidification of the colon contents attracts ammonia from the bloodstream, assisting stool excretion; helpful in liver failure when ammonia cannot be detoxified. (NCI04)
C29149	Laetrille	Cyanoglycoside_Agent	Laetrille|Laetrile	Originally, the name laetrile was the contraction of laevo-mandelonitrile glucoside, a cyanogenic glycoside found naturally in some plants.  Over the years the meaning of laetrile has changed.  There are now preparations called Laetrile where amygdalin is the major constituent.  Laetrile and amygdalin are often used interchangeably, but are different agents.  Cyanide and benzaldehyde are metabolites of both laetrile and amygdalin.  Both metabolites may possess antineoplastic properties.  Laetrile has been used as an anticancer treatment in humans worldwide, but scientific evidence does not support its effectiveness.  It is not approved for use in the United States. (NCI04)
C29150	Lansoprazole	Proton_Pump_Inhibitor	Lansoprazole|LANSOPRAZOLE|Prevacid	A substituted benzimidazole and selective and irreversible proton pump inhibitor. Lansoprazole is converted to active sulfenamide derivatives in the acidic environment of the gastric parietal cell. Lansoprazole sulfenamide binds to the gastric proton pump, H+/K+ ATPase, by forming a stable disulfide bond with the sulfhydryl group near the potassium-binding site on the luminal side. This inactivates ATPase, thereby decreasing the efflux and diminishing gastric acid secretion. Lansoprazole does not have anticholinergic or histamine H2 -receptor antagonistic properties.
C29151	Latanoprost	Anti-glaucoma_Agent	Latanoprost|Xalantan
C29152	Levarterenol_Bitartrate	Hypotensive_Agent	Levarterenol Bitartrate
C29153	Levobunolol	Anti-glaucoma_Agent	Levobunolol Hydrochloride|Betagan|LEVOBUNOLOL HYDROCHLORIDE|Levobunolol
C29154	Liboxin	Retired_Concepts	Liboxin
C29155	Lidobenalox	Magic_Mouthwash	Lidobenalox|Lidobenalox Solution|Lidocain,Viscous/Benadryl/Maalox	An oral suspension of viscous lidocaine, diphenhydramine (Benadryl) and aluminum and magnesium hydroxides (Maalox). This agent possesses anesthetic, antihistamine, and antacid properties. (NCI04)
C29156	Lidobenalox_Solution	Retired_Concepts	Lidobenalox Solution
C29158	Linezolid	Miscellaneous_Antibiotic	Linezolid|LINEZOLID|Zyvox	A synthetic oxazolidinone derivative, Linezolid selectively inhibits an early step in bacterial protein synthesis and affects blood pressure through monoamine oxidase inhibition. It is effective against Gram-positive organisms, including methicillin-resistant Staphylococcus aureus strains, coagulase-negative Staphylococci, vancomycin-resistant Enterococci, and penicillin-resistant Streptococcus pneumoniae strains. (NCI04)
C29159	Lisinopril	Antihypertensive_Agent	Lisinopril|LISINOPRIL|Prinivil|Zestril	A synthetic peptide derivate and long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Lisinopril specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II. This leads to a diminished vasopressor activity. In addition, angiotensin II-stimulated aldosterone secretion by adrenal cortex is decreased which results in a decrease of sodium and water retention and an increase of serum potassium.
C29160	Lodoxamide_Tromethamide	Mast_Cell_Stabilizer	Lodoxamide Tromethamine|Alomide|LODOXAMIDE TROMETHAMINE|Lodoxamide Tromethamide	The tromethamide salt form of lodoxamide, an ophthalmic mast cell stabilizer. Upon administration to the eye, lodoxamide tromethamide inhibits type I immediate hypersensitivity reaction by preventing the antigen-stimulated calcium influx into mast cells, thereby inhibiting release of histamine. Lodoxamide tromethamide also prevents the release of slow-reacting substances of anaphylaxis (SRS-A) and inhibits eosinophil chemotaxis.
C29161	Lomotrex	Retired_Concepts	Lomotrex
C29162	Loratadine	Histamine-1_Receptor_Antagonist	Loratadine|Claritin|LORATADINE	A piperidine histamine H1-receptor antagonist with anti-allergic properties and without sedative effects. Loratadine blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. Loratadine does not cross the blood-brain barrier and does not cause central nervous system effects.
C29163	Loratadine_Pseudoephedrine	Cough_and_Cold_Preparation	Loratadine/Pseudoephedrine|Claritin D|Pseudoephedrine/Loratadine|Pseudophedrine/Loratadine
C29164	Lorcet	Retired_Concepts	Lorcet
C29165	Losartan_Potassium	Antihypertensive_Agent	Losartan Potassium|2-Butyl-4-chloro-1-[[2'-(1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol, Monopotassium Salt|Cozaar|LOSARTAN POTASSIUM|Losartan	The potassium salt form of losartan, a non-peptide angiotensin II antagonist with antihypertensive activity. Losartan potassium selectively and competitively blocks the binding of angiotensin II to the angiotensin I (AT1) receptor. Angiotensin II, formed from angiotensin I by angiotensin-converting enzyme (ACE), stimulates the adrenal cortex to synthesize and secrete aldosterone, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle. Losartan potassium, by blocking the binding of angiotensin II to the AT 1 receptor, promotes vasodilatation and decreases the effects of aldosterone.
C29166	Losartan_Hydrochlorothiazide	Antihypertensive_Preparation	Losartan/Hydrochlorothiazide|Hyzaar
C29167	Lotion	Pharmaceutical_Dosage_Form	Lotion Dosage Form|LOTION|Lotion|Lotion Dose Form	A liquid preparation for bathing the skin, or an injured or diseased part, either for a medicinal purpose, or for improving its appearance. (On-line Medical Dictionary)
C29168	Amlodipine_Besylate_Benazepril_Hydrochloride	Antihypertensive_Preparation	Amlodipine Besylate/Benazepril Hydrochloride|Lotrel	Having a substantial blood pressure lowering capability, Amlodipine Besylate Benazepril Hydrochloride contains a dihydropyridine calcium blocker (amlodipine) and an angiotensin-converting enzyme (ACE) inhibitor (benazepril). A long-acting calcium channel antagonist, Amlodipine inhibits transmembrane calcium influx into vascular smooth muscle. Blocking ACE, Benazepril decreases vasopressive plasma angiotensin II. (NCI04)
C29169	Lubriderm	Topical_Preparation	Lubriderm
C29170	Lubrin	Topical_Preparation	Lubrin
C29171	Lysine	Essential_Amino_Acid	Lysine	One of nine essential amino acids in humans required for growth and tissue repair, Lysine is supplied by many foods, especially red meats, fish, and dairy products. Lysine seems to be active against herpes simplex viruses and present in many forms of diet supplements. The mechanism underlying this effect is based on the viral need for amino acid arginine; lysine competes with arginine for absorption and entry into cells. Lysine inhibits HSV growth by knocking out arginine. (NCI04)
C29172	M_A_131I_Osteogenic_Sarcoma	Radioimmunoconjugate	M A 131I Osteogenic Sarcoma	A radioimaging agent consisting of the 131 I-labeled murine monoclonal antibody 791T/36 which is directed against the tumor-associated antigen 791Tgp72. M A 131I Osteogenic Sarcoma binds to an antigen found in osteogenic sarcomas and colorectal and breast carcinomas, thereby enabling the scintigraphic visualization of primary and metastatic tumors that express 791Tgp72. (NCI04)
C29173	M_A_B72_3_CEL	Retired_Concepts	M A B72.3 (CEL)	A monoclonal antibody directed against an epitope derived from tumor-associated glycoprotein 72 (TAG-72) with potential antineoplastic activity.  M A B72.3 (CEL) binds to the majority of human adenocarcinomas (colorectal, gastric, pancreatic, ovarian, endometrial, mammary) that express TAG-72. (NCI04)
C29174	Monoclonal_Antibody_hB72_3	Monoclonal_Antibody	Monoclonal Antibody hB72.3|M A B72.3 (Damon)	A humanized monoclonal antibody directed against tumor-associated glycoprotein 72 (TAG72).  TAG72 is expressed in gastric, breast, pancreatic, colorectal, and ovarian carcinomas. (NCI04)
C29175	Monoclonal_Antibody_B72_3F	Monoclonal_Antibody	Monoclonal Antibody B72.3F(ab)|M A B72.3F	A mouse monoclonal antibody of the immunoglobulin G kappa subclass directed against the tumor-associated glycoprotein TAG-72. TAG-72 may be expressed in a variety of adenocarcinomas including colorectal and ovarian adenocarcinomas. Monoclonal Antibody B72.3F(ab) is generally not immunoreactive with normal adult tissues, but may crossreact with normal salivary gland ducts, normal post-ovulatory endometria, some benign ovarian tumors, and fetal gastrointestinal tissues. (NCI04)
C29176	Monoclonal_Antibody_hLEU_2A	Monoclonal_Antibody	Monoclonal Antibody hLEU 2A|M A Human T-Cell Antigen LEU 2A	A recombinant monoclonal antibody directed against the human suppressor-cytotoxic T-cell subset and designed to deplete circulating Leu 2A-positive lymphocytes.  The antigen LEU 2A, also known as CD8, is present on a subset of natural killer (NK) lymphocytes as well as the on the human suppressor/cytotoxic T-lymphocyte subset. (NCI04)
C29177	M_A_Idiotypic_Determinants	Radioimmunoconjugate	M A Idiotypic Determinants|M A IDIOTYPIC DETERMINANTS	A monoclonal antibody, subtype IgG2a, that targets lactate dehydrogenase (LDH) with potential use in cancer immunotherapy and immunodiagnostics.  Isoforms of LDH are recognized by the immune systems of patients with breast cancer, indicating that these antigens may be expressed by breast cancer cells.  Consequently, M A idiotypic determinants may have utility in the immunodiagnosis or immunotherapy of certain types of cancer. (NCI04)
C29178	Melanoma_Monoclonal_Antibody_hIgG2A	Monoclonal_Antibody	Melanoma Monoclonal Antibody hIgG2A|M A IG2A Human Melanoma	One of a number human monoclonal antibodies of the immunoglobulin subclass IgG2a directed against melanoma antigens with potential antineoplastic activity.  A melanoma monoclonal antibody, subclass IgG2A, may have potential use as a diagnostic agent and, therapeutically, may induce macrophage-mediated cytotoxicity against antibody-bound melanoma cells. (NCI04)
C29179	M_A_Radiolabeled_Anti-BRST_Cancer	Radioimmunoconjugate	M A Radiolabeled Anti-BRST Cancer|M A RADIOLABELED ANTI-BRST CANCER	A radiolabeled monoclonal antibody directed against an antigen expressed by breast cancer cells with potential use in cancer immunodiagnostics and immunotherapy. (NCI04)
C29180	M_A_Radiolabeled_Anti-Carcinoma	Radioimmunoconjugate	M A Radiolabeled Anti-Carcinoma|M A RADIOLABELED ANTI-CARCINOMA	A radiolabeled monoclonal antibody (also known as B72.3) directed against the tumor-associated glycoprotein (TAG)-72 with potential use in cancer radioimmunodiagnostics, radioimmunoscintigraphy, and radioimmunoguided surgery (RIGS). (TAG)-72 is an antigen that may be expressed by breast, colorectal, and ovarian carcinomas. (NCI04)
C29181	M_A_Radiolabeled_T101_Human_T-LYMP	Radioimmunoconjugate	M A Radiolabeled T101 Human T-LYMP|M A RADIOLABELED T101 HUMAN T-LYMP	A radiolabeled murine monoclonal antibody (also known as T101) directed against T65, an antigen found on cutaneous T cell lymphoma (CTCL) cells and chronic lymphocytic leukemia (CLL) cells as well as normal T lymphocytes. T101 labeled with 131I, 125I, or 111In has potential use in the radioimaging of CTCL.  M A radiolabeled T101 human T-lymph may induce a cytotoxic T-cell response response against T65-expressing T cells. (NCI04)
C29182	M_A_T101_HUMAN_T-LYMPHOCYTE	Retired_Concepts	M A T101 HUMAN T-LYMPHOCYTE	A murine monoclonal antibody (also known as T101) directed against T65, an antigen found on cutaneous T cell lymphoma (CTCL) cells and chronic lymphocytic leukemia (CLL) cells as well as normal T lymphocytes.  M A T101 human T-lymphocyte binds to T cells that express T65, potentially promoting their removal from the circulation, and may induce a cytotoxic T-cell response against T65-expressing T-cells.  This agent may also be conjugated to toxins such as ricin for targeted delivery to T65-expressing T cells. (NCI04)
C29183	M_A_TAC_Conjugated_Pseudomonas_EXO	Radioimmunoconjugate	M A TAC Conjugated Pseudomonas EXO|M A TAC CONJUGATED PSEUDOMONAS EXO	An immunotoxin consisting of the monoclonal antibody anti-Tac directed against the interleukin 2 receptor (also known as IL-2R or CD25) conjugated to a derivative of the pseudomonas exotoxin.  M A Tac conjugated pseudomonas exo is cytotoxic against T lymphocytes that express IL-2R. (NCI04)
C29185	M-BADOC	Retired_Concepts	M-BADOC
C29187	MAGE-1_VACCINIA_CONTAM_BVDV	Vaccinia_Vaccine	MAGE-1 Vaccinia Contaminated with BVDV|MAGE-1 Vaccinia Contam/BVDV	A cancer vaccine consisting of a recombinant vaccinia virus encoding the tumor-associated gene MAGE-1 that is contaminated with bovine viral diarrhea virus (BVDV).  The MAGE-1 gene is a member of the melanoma antigen-encoding gene family which is expressed in various malignant tumors such as hepatocellular carcinoma and germ cell tumors in addition to melanoma.  Vaccination with vaccinia virus expressing human MAGE-1 may generate antitumoral T-cell responses.  BVDV is an RNA pestivirus that may contaminate vaccines due to its presence in the fetal calf serum used as a growth supplement in the tissue culture of mammalian cells used in vaccine production. (NCI04)
C29188	MAGE-3_Peptide_Amino_acid_sequence_FLWGPRALV_plus_H22806	Vaccine_Antigen	MAGE-3 Peptide (9-mer)|MAGE-3 Peptide (Amino acid sequence FLWGPRALV)	A peptide derived from MAGE-3, a tumor-associated protein expressed by a variety of cancer cell types, including melanoma, breast, colon, lung, and thyroid.  Dendritic cells harvested from a cancer patient may be exposed to or pulsed with the 9-mer MAGE-3 peptide (FLWGPRALV). Autologous vaccination with these altered dendritic cells may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for MAGE-3, resulting in decreased tumor growth. (NCI04)
C29191	MELENGESTEROL	Retired_Concepts	Melengesterol
C29192	Retroviral_Vector_MFGS-MOv18-gamma	Viral_Vector-Gene_Complex	Retroviral Vector MFGS-MOv18-gamma|MFG-S MOv18-gamma-in Retroviral
C29193	Michellamine_B	Reverse_Transcriptase_Inhibitor	Michellamine B	A natural naphtylisoquinoline alkaloid with antiviral properties isolated from the tropical plant Ancistrocladus korupensis.  Michellamine B inhibits HIV reverse transcriptase (RT) activity and HIV-induced cellular fusion and syncytium formation, thereby inhibiting the propagation of HIV types 1 and 2.  In addition, this agent inhibits human DNA polymerases alpha and beta.  Michellamine B is also a noncompetitive protein kinase C inhibitor and potent antioxidant. (NCI04)
C29195	MITINDOMIDE	Topoisomerase-II_Inhibitor	Mitindomide|4, 8-Ethenopyrrolo[3',4':3,4]cyclobut[1,2-f]isoindole-1,3,5,7(2H, 6H)tetrone, octahydro-	A bisdioxopiperazines analog with antineoplastic activity.  Mitinomide inhibits topoisomerase II and slowly promotes DNA-interstrand cross-linking, thereby inhibiting DNA repair, RNA and protein synthesis.  This agent acts without increasing topoisomerase II-DNA covalent cleavable complex formation, as do most topoisomerase inhibitors. (NCI04)
C29196	Monoclonal_Antibody_1_4	Monoclonal_Antibody	Monoclonal Antibody 1.4|MOAB 1.4	A monoclonal immunoglobulin G 1 (IgG1) antibody to murine leukemia virus (MuLV) 1.4. (NCI04)
C29197	Monoclonal_Antibody_1_4_F_ab	Monoclonal_Antibody	Monoclonal Antibody 1.4 F(ab)|MOAB 1.4 FAB	A nonspecific monoclonal antibody Fab fragment for murine leukemia virus (MuLV) 1.4.  Monoclonal antibody 1.4 F(ab) has been used as a control in tests of specific monoclonal antibodies to cancers such as melanoma. (NCI04)
C29198	Monoclonal_Antibody_1F5	Monoclonal_Antibody	Monoclonal Antibody 1F5|Anti-CD20 Monoclonal Antibody 1F5|MOAB 1F5	A murine monoclonal antibody directed against CD20, a cross-membrane ion channel phosphoprotein expressed by B cells, with potential antineoplastic activity.  MOAB 1F5 binds to CD20, thereby directly inhibiting B-cell proliferation and differentiation. When cross-linked by secondary anti-mouse antibodies or Fc receptor-bearing cells, MOAB 1F5 may induce activation of B-cell protein tyrosine kinases, increases in B-cell intracellular calcium ion concentrations, and B-cell caspase activation, resulting in apoptosis of B cells expressing CD20. (NCI04)
C29199	Monoclonal_Antibody_48_7	Monoclonal_Antibody	Monoclonal Antibody 48.7|MOAB 48.7
C29200	Monoclonal_Antibody_48_7_F_ab	Monoclonal_Antibody	Monoclonal Antibody 48.7 F(ab)|MOAB 48.7 FAB
C29201	Monoclonal_Antibody_528	Monoclonal_Antibody	Monoclonal Antibody 528|MOAB 528 to EGF Receptor	A monoclonal antibody against the epidermal growth factor receptor (EGFR).  EGFR is a tyrosine kinase overexpressed or upregulated in various types of cancer.  By binding to EGFR, monoclonal antibody 528 specifically inhibits the activity of the EGFR tyrosine kinase. (NCI04)
C29202	Monoclonal_Antibody_8_2	Monoclonal_Antibody	Monoclonal Antibody 8.2|MOAB 8.2
C29203	Monoclonal_Antibody_8_2_F_ab	Monoclonal_Antibody	Monoclonal Antibody 8.2 F(ab)|MOAB 8.2 FAB
C29204	Monoclonal_Antibody_9_2_27_F_ab	Monoclonal_Antibody	Monoclonal Antibody 9.2.27 F(ab)|9.2.27 FAB|MOAB 9.2.27 FAB	The Fab fragment of the 9.2.27 monoclonal antibody.  9.2.27 monoclonal antibody recognizes the high-molecular-weight melanoma-associated antigen (HMW-MAA), an antigen expressed on a majority of melanomas.  Monoclonal antibody 9.2.27 FAB binds with high affinity to melanoma cells and has potential use in immunodiagnostic imaging and the immunotherapy of melanoma.  Monoclonal antibody 9.2.27 FAB exhibits improved tumor localization and a shorter half-life than the complete antibody. (NCI04)
C29205	Monoclonal_Antibody_96_5	Monoclonal_Antibody	Monoclonal Antibody 96.5|MOAB 96.5
C29206	Monoclonal_Antibody_96_5_F_ab	Monoclonal_Antibody	Monoclonal Antibody 96.5 F(ab)|96.5 FAB|MOAB 96.5 FAB
C29207	MOAB_B-3-CHX-A-DTPA	Immunoconjugate	MOAB B-3-CHX-A-DTPA
C29208	Monoclonal_Antibody_B6_2_F_ab	Monoclonal_Antibody	Monoclonal Antibody B6.2 F(ab')|MOAB B6.2 F(AB')	The Fab fragment of the B6.2 monoclonal antibody that recognizes the B6.2 antigen, a 90,000-d glycoprotein found on the surface of human mammary tumors.  MOAB B6.2 F (AB') binds to breast carcinoma cells and has potential use in immunodiagnostic imaging and the immunotherapy of breast cancer. MOAB B6.2 F (AB') exhibits improved tumor localization and a shorter half-life than the complete antibody. (NCI04)
C29209	Monoclonal_Antibody_B6_2F_ab_2	Monoclonal_Antibody	Monoclonal Antibody B6.2F(ab')2|B6.2F(AB)2 Abfragments|MOAB B6.2F(AB')2
C29210	Monoclonal_Antibody_BL-3	Monoclonal_Antibody	Monoclonal Antibody BL-3|BL-3 Monoclonal Antibody|MOAB BL-3	An isotype-matched monoclonal antibody that is used as a control when testing other monoclonal antibodies. (NCI04)
C29211	MOAB_BOMBESIN_2A11	Monoclonal_Antibody	Monoclonal Antibody 2A11|MOAB Bombesin|MOAB Bombesin (2A11)	A recombinant, murine monoclonal antibody directed against gastrin-releasing peptide, one of a number of bombesin-like peptides (BLP). Tumor cells, such as small cell lung cancer (SCLC) cells, express and secrete BLP that activate specific cell growth-promoting receptors. Monoclonal antibody 2A11 has been shown to decrease the growth of SCLC cells in vitro and in animal models. (NCI04)
C29212	MOAB_BOMBESIN_DTPA	Radioimmunoconjugate	MoAb Bombesin (DTPA)|MOAB BOMBESIN (DTPA)	A monoclonal antibody directed against the neurohormone bombesin that is conjugated to diethylenetriaminepenta-acetic acid (DPTA), a bifunctional chelating agent that allows the antibody to be labeled with a metal species such as radioactive indium.  Levels of bombesin, also known as gastrin releasing peptide (GRP), are elevated in lung and thyroid cancers, where the substance acts as an autocrine growth factor. (NCI04)
C29213	MOAB_BOMBESIN_ITC-D	Radioimmunoconjugate	MoAb Bombesin (ITC-D)|MOAB BOMBESIN (ITC-D)	A monoclonal antibody directed against the neurohormone bombesin that is conjugated to isothiocyanobenzyl diethylenetriaminepentaacetic acid (ITC-D), a bifunctional chelating agent that allows the antibody to be labeled with a metal species. Levels of the neurohormone bombesin, also known as gastrin releasing peptide (GRP), are elevated in lung and thyroid cancers, where the substance acts as an autocrine growth factor. (NCI04)
C29215	Monoclonal_Antibody_CC-83	Monoclonal_Antibody	Monoclonal Antibody CC-83|MOAB CC-83/TAG72|Murine Monoclonal Antibody CC-83 to TAG72	A second-generation murine monoclonal antibody based on monoclonal antibody B72.3 and directed against tumor-associated glycoprotein 72 (TAG72).  TAG72 is expressed in gastric, breast, pancreatic, colorectal, and ovarian carcinomas. (NCI04)
C29216	Monoclonal_Antibody_CC-92	Monoclonal_Antibody	Monoclonal Antibody CC-92|MOAB CC-92/TAG72|Murine Monoclonal Antibody CC-92 to TAG72	A second-generation murine monoclonal antibody based on the monoclonal antibody B72.3 and directed against tumor-associated glycoprotein 72 (TAG72).  TAG72 is expressed in gastric, breast, pancreatic, colorectal, and ovarian carcinomas. (NCI04)
C29217	Monoclonal_Antibody_CEM-231	Anti-CEA_Antibody	Monoclonal Antibody CEM-231|MOAB CEM-231	A monoclonal antibody directed against carcinoembryonic antigen (CEA) which is expressed by most gastrointestinal carcinomas and by some breast, lung and ovarian carcinomas. (NCI04)
C29219	Monoclonal_Antibody_COL-6	Monoclonal_Antibody	Monoclonal Antibody COL-6|MOAB COL-6
C29220	Monoclonal_Antibody_45-2D9	Monoclonal_Antibody_to_Colorectal_Cancer	Monoclonal Antibody 45-2D9|MOAB Colorectal (45-2D9)	A synthetic antibody targeted against a cell surface glycoprotein (gp74) on a human c-Ha-ras oncogene transformed cell line.  Monoclonal Antibody 45-2D9 also recognizes this epitope on certain human tumor cells. (NCI04)
C29221	MOAB_Colorectal_Carcinoma	Retired_Concepts	MOAB Colorectal Carcinoma
C29222	Monoclonal_Antibody_HD37-SMPT-dgA_Immunotoxin	Ricin_Immunoconjugate	Monoclonal Antibody HD37-SMPT-dgA Immunotoxin|IgG-HD37-SMPT-dgA|MoAb HD37-SMPT-DGA Immunotoxin|MoAb HD37-SMPT-dgA Immunotoxin	An immunotoxin consisting of the murine anti-CD19 monoclonal antibody HD37 conjugated to a deglycosylated ricin A chain (dgA) via the linking molecule N-succinimidyl-oxycarbonyl-alpha-methyl-alpha-(2-pyridyldithio) toluene (SMPT).  The HD37 component binds to CD19, a B-cell restricted antigen, thereby targeting the delivery of the cytotoxic ricin A chain to B-cells. The ricin A chain component binds to B-cells and disrupts ribosomal activity and protein synthesis and induces cell cycle arrest. (NCI04)
C29223	Monoclonal_Antibody_BL3-GD_Idiotypic_Determinant	Monoclonal_Antibody	Monoclonal Antibody BL3-GD Idiotypic Determinant|MOAB Idiotypic Determ BL3-GD	An idiotypic determinant of a monoclonal antibody directed against antigens preferentially expressed by the cell line BL-3 derived from bovine leukemia or lymphoma (BL) cells. (NCI04)
C29224	Monoclonal_Antibody_IMMU-14	Anti-CEA_Antibody	Monoclonal Antibody IMMU-14|MOAB IMMU-14	An anti-carcinoembryonic antigen (anti-CEA) murine monoclonal immunoglobulin G (IgG) with potential antineoplastic activity.  CEA is overexpressed in several cancer cell types, including gastrointestinal, breast, and non-small cell lung cancers.  MOAB IMMU-14 can be conjugated with a radioactive element for use in radioimmunotherapy (RIT), a regimen that uses a tumor-specific monoclonal antibody to deliver targeted radiation to cancer cells. (NCI04)
C29225	Monoclonal_Antibody_LYM-2	Monoclonal_Antibody	Monoclonal Antibody LYM-2|MOAB LYM-2	A recombinant murine monoclonal antibody directed against a human class II molecule variant found on the surfaces of normal and neoplastic human B cells. Monoclonal antibody LYM-2 may induce cell-mediated lysis of neoplastic human B cells. (NCI04)
C29226	Monoclonal_Antibody_N901-bR	Ricin_Immunoconjugate	Monoclonal Antibody N901-bR|MOAB N901-BR|MOAB N901-bR	A synthetic immunotoxin consisting of the murine monoclonal antibody N901 conjugated with toxin-blocked ricin (BR).  Monoclonal antibody N901-BR binds to CD56, a neural cell adhesion molecule (NCAM) that is expressed by tumor cells of neuroectodermal origin (including small cell lung cancer (SCLC) and neuroblastoma), and by normal cells (including neuroendocrine cells, cardiac muscle cells, and cells in peripheral nerve tissue).  (NCI04)
C29227	Monoclonal_Antibody_NR-CO-04	Monoclonal_Antibody	Monoclonal Antibody NR-CO-04|MOAB NR-CO-04
C29228	Monoclonal_Antibody_OVB3-PE	Immunotoxin	Monoclonal Antibody OVB3-PE|MOAB OVB3-P3|MOAB OVB3-PE	A recombinant monoclonal antibody (OVB3) directed against human ovarian cancer linked with an exotoxin derived from the bacterium Pseudomonas aeruginosa.  The antibody portion of the agent binds to human ovarian cancer cells; the pseudomonas exotoxin, a 66 kDa protein belonging to a family of enzymes known as mono-(ADP-ribosyl) transferases, stops tumor cell protein synthesis by inactivating elongation factor 2 and disrupting protein synthesis.. (NCI04)
C29229	Monoclonal_Antibody_RG_83852	Monoclonal_Antibody	Monoclonal Antibody RG 83852|MOAB RG 83852	A murine monoclonal antibody directed against the human epidermal growth factor receptor (EGFR).  Monoclonal antibody RG 83852 binds to the EGFR, inhibiting the high-affinity binding of epidermal growth factor (EGF) and receptor activation. Overexpression of EGFR, a tyrosine kinase, and its upregulated activity have been implicated in the pathogeneses of several malignancies. (NCI04)
C29230	In_111_Monoclonal_Antibody_Anti-TAC	Radioimmunoconjugate	In 111 Monoclonal Antibody Anti-TAC|MOAB TAC-111IN
C29233	MOv-gamma	Retired_Concepts	MOv-gamma	A chimeric antigen receptor gene derived from the murine monoclonal antibody MOv18 that binds to folate-binding protein (FBP).  Peripheral blood lymphocytes (PBL) are first harvested from a cancer patient and induced to express MOv-gamma.  Autologous vaccination with these activated PBL stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against ovarian cancer cells which often overexpress FBP. (NCI04)
C29234	MSM_Glucosamine	Antirheumatic_Preparation	MSM/Glucosamine|MSM w/Glucosamine
C29236	Mouse_Monoclonal_Antibody_LYM-1	Retired_Concepts	Murine Monoclonal Antibody (LYM-1)
C29237	Murine_Monoclonal_Antibody_D612	Monoclonal_Antibody	Murine Monoclonal Antibody D612	A murine monoclonal antibody directed against human colorectal carcinoma-associated cell-surface antigen D612. (NCI04)
C29238	Magic_Mouthwash	Analgesic_Preparation	Magic Mouthwash
C29239	Magnesium	Nutritional_Supplement	Magnesium	An alkaline earth metal, Magnesium is important for many biochemical functions and reactions; for bone and muscle function, protein and fatty acid formation, activation of B vitamins, blood clotting, insulin secretion, and ATP formation. More than 300 enzymes require magnesium for catalytic action. The adult daily requirement is about 300 mg/day. Magnesium is found in many green plants, vegetables, and seeds; chlorophyll is a magnesium-centered porphyrin compound. Magnesium salts are used for magnesium deficiency supplementation. (NCI04)
C29240	Magnesium_Chloride	Nutritional_Supplement	Magnesium Chloride	Magnesium Chloride was used as a laxative. An alkaline earth metal, magnesium is important for many biochemical functions and reactions; for bone and muscle function, protein and fatty acid formation, activation of B vitamins, blood clotting, insulin secretion, and ATP formation. More than 300 enzymes require magnesium for catalytic action. The adult daily requirement is about 300 mg/day. Magnesium is found in many green plants, vegetables, and seeds; chlorophyll is a magnesium-centered porphyrin compound. Magnesium salts are used for magnesium deficiency supplementation. (NCI04)
C29241	Magnesium_Citrate	Nutritional_Supplement	Magnesium Citrate	Well absorbed into the bloodstream, Magnesium Citrate is used as a laxative or for supplementation in magnesium deficiency. Important for many biochemical functions and reactions, magnesium is needed for bone and muscle function, protein and fatty acid formation, activation of B vitamins, blood clotting, insulin secretion, and ATP formation. More than 300 enzymes require magnesium for catalytic action. The adult daily requirement is about 300 mg/day. Magnesium is found in many green plants, vegetables, and seeds; chlorophyll is a magnesium-centered porphyrin compound. (NCI04)
C29242	Magnesium_Oxide	Laxative|Nutritional_Supplement	Magnesium Oxide|MAGNESIUM OXIDE
C29244	Choline_Magnesium_Trisalicylate	Nonsteroidal_Antiinflammatory_Drug	Choline Magnesium Trisalicylate|Magnesium trisalicylate|Trilisate|Trisalicylate	A nonsteroidal anti-inflammatory drug (NSAID) belonging to the salicylate family.  Choline magnesium trisalicylate inhibits inflammation-related prostaglandin synthesis. This agent's analgesic effect is mediated through peripheral and central pathways, resulting in a decrease in pain perception; its antipyretic effect is mediated via the hypothalamic heat regulation center. (NCI04)
C29245	Meclizine_Hydrochloride	Antiemetic_Agent|Histamine-1_Receptor_Antagonist	Meclizine Hydrochloride|1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine Dihydrochloride Monohydrate|Antivert|Bonine|MECLIZINE HYDROCHLORIDE|Meclizine|Meclizine HCl
C29247	Meglumine_Amidotrizoate	Contrast_Agent	Meglumine Amidotrizoate	A contrast medium based on diatrizoic acid or amidotrizoic acid solutions.  Meglumine amidotrizoate is used in a wide variety of imaging procedures including: cerebral, thoracic, abdominal and extremity angiography, phlebography, computerized tomography, for visualisation of cavities of the body, amniography, arthrography, fistulography, hysterosalpingography, vesiculography. (NCI04)
C29248	Meropenum	Retired_Concepts	Meropenem|Merrem I.V.
C29249	Mesalamine	Miscellaneous_Adjuvant	Mesalamine|5-Amino-2-hydroxybenzoic Acid|5-Aminosalicylic Acid|Asacol|MESALAMINE|Mesalazine|Pentasa|Rowasa	An agent derived from sulfasalazine, an antiinflammatory agent.  Mesalamine may reduce inflammation through inhibition of cyclooxygenase and prostaglandin production. Following rectal or oral administration, only a small amount of mesalamine is absorbed; the remainder, acting topically, reduces bowel inflammation, diarrhea, rectal bleeding and stomach pain. (NCI04)
C29250	Psyllium_Husk	Laxative	Psyllium|Isogel|Ispaghula|Metamucil|Plantaglucide|Psyllium Gum|Psyllium Husk|Psyllium Seed Gum|Psyllium Seed Husk
C29251	Metformin_Hydrochloride	Anti-diabetic_Agent	Metformin Hydrochloride|1,1-Dimethylbiguanide|Glucophage|METFORMIN HYDROCHLORIDE|Metformin|Metformin HCl|N,N-Dimethylimidodicarbonimidic Diamide
C29252	Methocarbamol	Muscle_Relaxant	Methocarbamol|METHOCARBAMOL|Robaxin
C29253	Methylcellulose	Laxative	Methylcellulose|Citrucel
C29254	Metoprolol_Succinate	Beta-Adrenergic_Blocking_Agent	Metoprolol Succinate|METOPROLOL SUCCINATE|Toprol XL
C29255	Metoprolol_Tartrate	Beta-Adrenergic_Blocking_Agent	Metoprolol Tartrate|Lopressor|METOPROLOL TARTRATE
C29256	Micellar_Paclitaxel	Paclitaxel	Micellar Paclitaxel|Paxceed
C29257	Miconazole	Antifungal_Agent	Miconazole Nitrate|1-[2-(2,4-Dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]-1H-imidazole|Lotrimin|MICONAZOLE NITRATE|Micatin|Miconazole|Monistat	An antifungal synthetic derivative of imidazole and used in the treatment of candidal skin infections, Miconazole selectively affects the integrity of fungal cell membranes, high in ergosterol content and different in composition from mammalian cells membranes. (NCI04)
C29258	Pyrilamine_Caffeine_Acetaminophen	Analgesic_Preparation	Pyrilamine/Caffeine/Acetaminophen|Midol Menstrual
C29259	Pyrilamine_Pamabrom_Acetaminophen	Analgesic_Preparation	Pyrilamine/Pamabrom/Acetaminophen|Midol PMS
C29260	Isometheptane_Dichloralphenazone_Acetaminophen	Analgesic_Preparation	Isometheptene/Dichloralphenazone/Acetaminophen|Midrin
C29261	Milk_Thistle	Antioxidant|Nutritional_Supplement	Milk Thistle	A substance derived from any of several Old World coarse prickly-leaved shrubs and subshrubs including the plant Silybum marianum.  Milk thistle's active chemical component is silymarin, which is a combination of flavonoids such as silibinin, dehydrosilibinin, silychristin and silydianin.  These compounds are antioxidants and may alter the membrane structure of the liver cell, thereby blocking the absorption of toxins; they may also stimulate the production of new liver cells. In addition, milk thistle may increase cellular adenosine triphosphate (ATP) levels, exhibiting dose-dependent cardiac myocyte cytoprotection against doxorubicin.  The silibinin component of milk thistle has been shown to inhibit growth factor receptor-mediated mitogenic and cell survival signaling, thereby inhibiting tumor growth. (NCI04)
C29262	Milk_of_Magnesium	Laxative	Magnesium Hydroxide|MAGNESIUM HYDROXIDE|Milk of Magnesium
C29263	Milrinone_Lactate	Phosphodiesterase_Inhibitor	Milrinone Lactate|Primacor	A bipyridine agent with positive inotropic and vasodilator properties.  Milrinone lactate selectively inhibits fraction III cyclic adenosine monophosphate (cAMP) phosphodiesterase isozymes in the heart and vascular muscles, thereby increasing cAMP and, consequently, an increase in cAMP-dependent intracellular ionized calcium and myocardium contractile force, and vasodilation in arteriolar and venous vascular smooth muscle.  This agent improves hemodynamics in patients with ventricular dysfunction by increasing the stroke volume index and left ventricular contractility and by producing pulmonary vasodilation. (NCI04)
C29264	Mineral_Oil	Carcinogenic_Hydrocarbon	Mineral Oil	A mixture of liquid paraffinic, naphthenic and polycyclic aromatic hydrocarbons obtained from petroleum in which the amount and types of aromatic hydrocarbons is dependent on the treatment process. Untreated and mildly treated mineral oils contain the highest amount of aromatic and unsaturated compounds and are primarily used as a lubricant base oil to produce further refined oil products. Exposure to these types of mineral oils can cause rapid respiration, cyanosis, tachycardia and low-grade fever. Untreated and mildly treated mineral oils are strongly associated with an increased risk of scrotal and skin cancer but can also cause gastrointestinal, rectal, bladder and certain respiratory-tract cancers. (NCI05)
C29265	Mirtazapine	Antidepressant_Agent	Mirtazapine|MIRTAZAPINE|Remeron	A synthetic derivative of piperazino-azepines, tetracyclic antidepressant Mirtazapine acts by an unknown mechanism that enhances central adrenergic and serotonergic transmission. Structurally unrelated to selective serotonin reuptake inhibitors, tricyclics, or monoamine oxidase inhibitors (MAOI), it also affects muscarinic transmission and has parasympatholytic properties. (NCI04)
C29266	Mivopenim	Muscle_Relaxant	Mivopenim
C29267	Moexipril_Hydrochloride	ACE_Inhibitor	Moexipril Hydrochloride|MOEXIPRIL HYDROCHLORIDE|Moexipril HCl|Univasc	A non-sulfhydryl-containing non-peptide with antihypertensive activity.  As a prodrug, moexipril hydrochloride is hydrolized into its active form moexiprilat.  Moexiprilat inhibits angiotensin converting enzyme, thereby blocking the conversion of angiotensin I to angiotensin II, decreasing aldosterone secretion, increasing bradykinin levels and ultimately causing vasodilation. (NCI)
C29268	Mometasone_Furoate	Therapeutic_Glucocorticoid	Mometasone Furoate|(11beta,16alpha)-9,21-Dichloro-17-[(2-furanylcarbonyl)oxy]-11-hydroxy-16-methylpregna-1,4-diene-3,20-dione|Elocon|MOMETASONE FUROATE|Nasonex|Sch-32088
C29269	Mouthwash	Solution_Dosage_Form	Mouthwash Dosage Form|MOUTHWASH|Mouthwash|Mouthwash Dose Form	An aqueous solution which is most often used for its deodorant, refreshing, or antiseptic effect.
C29270	Multivitamins_Minerals	Nutritional_Supplement	Multivitamins/Minerals	A dietary supplement containing all or most of the vitamins and some minerals which may not be readily available in the diet.  The vitamin component may be classified according to their solubility either in lipids (vitamins A, D, E, K, F) or in water (vitamins C, B- complex). Present in minute amounts in various foods, vitamins are essential to maintaining normal metabolism and biochemical functions. The mineral component contains essential microelements and metals such as iron, magnesium, chromium and iodine. In addition, these agents may include various anti-oxidant phytochemicals such as flavonoids. (NCI04)
C29271	Mupirocin	Topical_Anti-Infective_Agent	Mupirocin|Bactroban|MUPIROCIN	A natural crotonic acid derivative extracted from Pseudomonas fluorescens, Mupirocin inhibits bacterial protein synthesis by specific reversible binding to bacterial isoleucyl transfer-RNA synthetase. With excellent activity against gram-positive staphylococci and streptococci, it is primarily used for treatment of primary and secondary skin disorders, nasal infections, and wound healing. (NCI04)
C29272	Mycophenolate	Immunosuppressant|Inosine_Monophosphate_Dehydrogenase_Inhibitor	Mycophenolate	The morpholinoethyl ester of mycophenolic acid (MPA).  As an immunosuppressive agent in vivo, the active metabolite mycophenolate reversibly inhibits inosine 5'-monophosphate dehydrogenase (IMPDH), an enzyme involved in the de novo synthesis of guanine nucleotides, thereby retarding T-cell and B-cell proliferation.  MPA displays high lymphocyte specificity and cytotoxicity because lymphocyte metabolism is highly dependent on both salvage and de novo synthesis of guanine nucleotides. (NCI04)
C29273	Mylanta	Antacid_Preparation	Mylanta
C29274	N_N-Dimethylacetamide	Drug_Vehicle	N, N-Dimethylacetamide|Acetic Acid, Dimethylamide|Dimethyl Acetamide|N,N-Dimethylacetamide
C29276	NA17_Peptide_Amino_acid_sequence_VLPDVFIRCV	Vaccine_Antigen	NA17 Peptide (Amino acid sequence VLPDVFIRCV)	A synthetic peptide vaccine derived from the melanoma antigen NA17. Dendritic cells (DC) harvested from a cancer patient may be exposed to or pulsed with the NA17 peptide (VLPDVFIRCV). Autologous vaccination with these altered dendritic cells may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for NA17, resulting in decreased tumor growth. (NCI04)
C29277	Nevirapine	Reverse_Transcriptase_Inhibitor	Nevirapine|NEVIRAPINE|Viramune	A synthetic, non-nucleoside reverse transcriptase (RT) inhibitor with antiviral properties.  Nevirapine binds directly to the human immunodeficiency virus type 1 (HIV-1) RT, an RNA-dependent DNA polymerase, blocking its function in viral DNA replication.  In combination with other antiretroviral drugs, this agent reduces HIV viral loads and increases CD4 counts, thereby retarding or preventing the damage to the immune system and reducing the risk of developing AIDS. (NCI04)
C29278	Nitroestron_Meth_ETH	Retired_Concepts	Nitroestron Meth ETH
C29279	Nandrolone	Anabolic_Steroid|Therapeutic_Androgen	Nandrolone|19-Nortestosterone|Estrenolone|Norandrostenolone|Nortestosterone|Nortestrionate	A synthetic, anabolic steroid analog of testosterone. Similar to testosterone, nortestosterone (19-Nortestosterone) binds to and activates specific nuclear receptors.  This agent may be used for testosterone replacement therapy in hypogonadal men, in HIV-wasting syndrome, and in other conditions in order to increase nitrogen retention and fat-free muscle mass. (NCI04)
C29280	Nadolol	Beta-Adrenergic_Blocking_Agent	Nadolol|Corgard
C29281	Nafcillin	Beta-Lactam_Antibiotic	Nafcillin Sodium|NAFCILLIN SODIUM|Nafcil|Nafcillin|Nallpen	A semi-synthetic naphthalene, penicillin-related Nafcillin inhibits bacterial wall synthesis by a mechanism of action similar to penicillin. Penicillinase-resistant Nafcillin is used to treat infections caused by penicillin-resistant strains of Staphylococci. (NCI04)
C29282	Nature_s_Remedy	Retired_Concepts	Nature's Remedy
C29283	Nefazadone_Hydrochloride	Antidepressant_Agent	Nefazodone Hydrochloride|NEFAZODONE HYDROCHLORIDE|Nefazadone HCl|Serzone	A synthetic derivative of phenylpiperazine and chemically unrelated to selective serotonin reuptake inhibitors, tricyclics, tetracyclics, or monoamine oxidase inhibitors (MAOI), antidepressant Nefazadone Hydrochloride antagonizes central 5-HT2 receptors and inhibits reuptake of serotonin and norepinephrine. (NCI04)
C29284	Nefludan	Retired_Concepts	Nefludan
C29285	Nelfinavir	Protease_Inhibitor	Nelfinavir	A synthetic antiviral agent.  Nelfinavir selectively inhibits human immunodeficiency virus (HIV) protease, thereby preventing cleavage of the gag-pol viral polyprotein and resulting in the release of immature, noninfectious virions.  In vivo, this agent exhibits broad tissue distribution compared to related agents. (NCI04)
C29286	Neosporin_Cream	Anti-infective_Preparation	Neosporin Cream
C29287	Neosporin_Ophthalmic	Anti-infective_Preparation	Neosporin Ophthalmic
C29288	Potassium_Phosphate-Sodium_Phosphate	Electrolyte_Replacement_Preparation	Potassium Phosphate/Sodium Phosphate|Neutra-Phos|Neutra-phos
C29289	Nifabutin	Retired_Concepts	Nifabutin
C29290	Nifedipine	Calcium_Channel_Blocker	Nifedipine|Adalat|NIFEDIPINE|Procardia	A dihydropyridine calcium channel blocking agent. Nifedipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
C29291	Nisoldipine	Calcium_Channel_Blocker	Nisoldipine|NISOLDIPINE|Nisoldipine SR|Sular	A dihydropyridine calcium channel blocking agent. Nisoldipine inhibits the transmembrane influx of extracellular calcium ions into myocardial and vascular smooth muscle cells, causing dilatation of the main coronary and systemic arteries and decreasing myocardial contractility. This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in some multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
C29293	Nitrofurantoin	Urinary_Anti-Infective_Agent	Nitrofurantoin|Macrobid|Macrodantin	A synthetic derivative of imidazolidinedione, Nitrofurantoin inhibits bacterial DNA, RNA, and cell wall protein synthesis. Activated by bacterial flavoproteins to intermediates that inactivate bacterial ribosomal proteins, Nitrofurantoin is used prophylactically as a urinary anti-infective agent against most gram-positive and gram-negative organisms and for long-term suppression of infections. (NCI04)
C29294	Nitroglycerin	Vasodilating_Agent	Nitroglycerin|NITROGLYCERIN
C29295	Nizatidine	Histamine-2_Receptor_Antagonist	Nizatidine|Axid
C29296	Nyquil	Cough_and_Cold_Preparation	Nyquil
C29297	OXY_104	Retired_Concepts	OXY 104
C29298	Oatmeal_Powder	Topical_Preparation	Oatmeal Powder|Aveeno
C29299	Olizumab	Monoclonal_Antibody	Olizumab|Rhumab-E25	A synthetic, chimeric monoclonal antibody directed against the C-epsilon 3 domain of immunoglobulin E.  Omalizumab binds to this IgE domain, thereby preventing IgE from binding to its high-affinity mast-cell receptor. (NCI04)
C29300	Opium_Tincture	Opiate	Opium Tincture	Also known as Laudanum and formulated for oral administration, Opium tincture is made of air-dried poppy (Papaver somniferum) latex and contains alkaloids such as morphine and codeine. As an antidiarrheal agent, it slows transit of intestinal contents by increasing intestinal smooth muscle tone and inhibiting motility; water is absorbed from fecal contents, decreasing diarrhea. (NCI04)
C29302	Ophthalmic_Solution	Topical_Preparation	Ophthalmic Solution
C29303	Orlistat	Gastrointestinal_Lipase_Inhibitor	Orlistat|ORLISTAT|Xenical	A reversible active-site inhibitor of gastrointestinal lipases.  Orlistat forms a covalent bond with the active serine site in gastric and pancreatic lipases, thereby inhibiting their activity and preventing dietary fat from being hydrolyzed and absorbed. (NCI04)
C29304	Ethinyl_Estradiol-Norgestimate	Oral_Contraceptive_Preparation	Ethinyl Estradiol/Norgestimate|Ortho Tri-Cyclen|Orthotricyclen
C29305	Oseltamivir	Miscellaneous_Antiviral_Agent	Oseltamivir Phosphate|OSELTAMIVIR PHOSPHATE|Oseltamivir|Tamiflu	A synthetic derivative prodrug of ethyl ester and used in certain cases of influenza, antiviral Oseltamivir interferes with the final life cycle stage of influenza virus (host cell release of completed viral particles) by blocking neuraminidases on the surface of flu viruses. (NCI04)
C29306	Oxandrolone	Anabolic_Steroid|Therapeutic_Androgen	Oxandrolone|OXANDROLONE|Oxandrin	A synthetic, anabolic steroid hormone analog of testosterone. Similar to testosterone, oxandrolone binds to and activates specific nuclear receptors. This agent may be used for testosterone replacement therapy in hypogonadal men, in HIV-wasting syndrome, and in other conditions in order to increase nitrogen retention and fat-free muscle mass. (NCI04)
C29307	Oxaprozin	Cyclooxygenase_Inhibitor	Oxaprozin|4,5-Diphenyl-2-oxazolepropionic Acid|Daypro|OXAPROZIN|Wy 21743	A nonsteroidal anti-inflammatory drug (NSAID) derivative of oxazole-propionic acid with analgesic and antipyretic properties.  As a first generation NSAID inhibitor, oxaprozin binds to and inactivates both isoforms of cyclooxygenase (COX-1 and-2), thereby blocking the conversion of arachidonic acid to pro-inflammatory prostaglandins.  When inhibiting COX-2, this agent may be effective in relieving pain and inflammation; when inhibiting COX-1, it may produce unacceptable gastrointestinal side effects. (NCI04)
C29308	Oxybutynin_Cloride	Antimuscarinic_Agent|Antispasmotic_Agent	Oxybutynin Chloride|Ditropan|OXYBUTYNIN CHLORIDE|Oxybutynin Cl
C29309	Oxycodone	Opioid	Oxycodone|4,5-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one|Oxycodone SR	OxyContin's active ingredient is oxycodone, a morphine-like substance that is also found in drugs like Percodan and Tylox. OxyContin Tablets are administered chronically to patients with cancer-related pain in a usual clinical setting.
C29311	Oxycodone_Acetaminophen	Analgesic_Preparation	Oxycodone/Acetaminophen
C29312	Oxycodone_Rixicodone	Retired_Concepts	Oxycodone/Rixicodone
C29313	Oxymetazoline_Hydrochloride	Alpha-adrenergic_Agonist	Oxymetazoline Hydrochloride|Afrin|OXYMETAZOLINE HYDROCHLORIDE|Oxymetazoline HCl
C29314	Oxymorphone	Opioid	Oxymorphone	A semisynthetic narcotic analgesic related to hydromorphone and other opiates, Oxymorphone, hydroxy-dihydromorphinone, affects the central nervous system and smooth muscles by activation of specific opiate receptors. Similar to morphine, but more potent and without cough suppressant activity, it is used in treatment of moderate to severe pain, including obstetrical pain, or as an adjunct to anaesthesia. (NCI04)
C29315	P32	Retired_Concepts	P32
C29316	rFowlpox-CEA_D609_MUC1_L93_TRICOM	Fowlpox_Virus_Vaccine	Recombinant Fowlpox-CEA-MUC-1-TRICOM Vaccine|Fowlpox-CEA(D609)-MUC1(L93)-Tricom Vaccine|PANVAC-F|PANVAC-F [rFowlpox-CEA(D609)/MUC1(L93)/Tricom|fCEA-MUC-1-TRI|rFowlpox-CEA(D609)/MUC1(L93)/Tricom Vaccine	A cancer vaccine comprised of a recombinant fowlpox viral vector encoding the carcinoembryonic antigen (CEA), MUC-1, a transmembrane glycoprotein secreted by glandular epithelial tissues, and TRICOM, comprised of three co-stimulatory molecule transgenes (B7-1, ICAM-1 and LFA-3). This agent may enhance CEA and MUC-1 presentation to antigen-presenting cells (APC) and activate a cytotoxic T-cell response against CEA- and MUC-1-expressing tumor cells. (NCI05)
C29317	rVaccinia-CEA_D609_MUC1_L93_TRICOM	Vaccinia_Vaccine	Recombinant Vaccinia-CEA-MUC-1-TRICOM Vaccine|PANVAC-V|PANVAC-V [rVaccinia-CEA(D609)/MUC1(L93)/TRICOM]|rVaccinia-CEA(D609)/MUC1(L93)/TRICOM Vaccine	A cancer vaccine comprised of a recombinant vaccinia viral vector encoding the carcinoembryonic antigen (CEA), MUC-1, a transmembrane glycoprotein secreted by glandular tissues, and TRICOM, comprised of three co-stimulatory molecule transgenes (B7-1, ICAM-1 and LFA-3). This agent may enhance CEA and MUC-1 presentation to antigen presenting cells (APC) and activate a cytotoxic T-cells response against CEA- and MUC-1-expressing tumor cells. (NCI05)
C29318	PCLUS_3_18MN_PCLUS_6_1_18MN	Retired_Concepts	PCLUS 3:18MN/PCLUS 6.1:18MN
C29320	Phetharbital	Anticonvulsant_Agent	Phetharbital	A short-acting barbiturate derivative without hypnotic properties, Phetharbital (N-phenylbarbital) can be used as a sedative and anticonvulsant agent due to its mechanism of enhancing GABA (Gamma Amino Butyric Acid) transmission and inhibition of synaptic excitation. Phetharbital has generally been withdrawn from clinical use. (NCI04)
C29321	Phosphate_Buffer	Reagent	Phosphate Buffer	A chemical reagent containing at least any one of the many phosphoric acid derivatives, usually in salt form.  The phosphoric salt may be one of three types: strongly acid monometallic, neutral or mildly alkaline dimetallic, and strongly alkaline tri-metallic.  Phosphate buffers are typically adjusted to maintain a certain pH or are "buffered" with other chemical compounds.  Phosphate reagents are used in research laboratories, medicine or industry in various technical procedures. (NCI04)
C29322	Phosphoramide_Mustard	Immunosuppressant|Nitrogen_Mustard_Compound	Phosphoramide Mustard	One of a number of chemically-related alkylating agents with antineoplastic properties.  The prototype of this group of agents is cyclophosphamide.  Most phosphoramide mustards are administered as prodrugs that undergo reductive activation in hypoxic environments to yield cytotoxic metabolites. These agents alkylate and crosslink DNA, resulting in inhibition of DNA replication. Phosphoramide mustards are also immunosuppressants, mutagens and teratogens. (NCI04)
C29323	Phsap	Retired_Concepts	Phsap
C29324	Phyllanthoside	Antineoplastic_Plant_Product	Phyllanthoside
C29326	PIXY	Retired_Concepts	PIXY
C29328	PNU-214565	Immunoconjugate	PNU-214565
C29329	Purified_Protein_Derivative	Immunostimulant	Purified Protein Derivative|PPD|PPD Tine Test|Tubersol	A purified protein extract derived from the bacterium Mycobacterium tuberculosis. Intradermally-administered, PPD stimulates preprimed CD4 T cells in immunologically competent subjects previously exposed to the bacterium Mycobacterium tuberculosis; these activated CD4 T cells secrete various cytokines that attract granulocytes, monocytes, and macrophages in an inflammatory response known as delayed hypersensitivity. (NCI04)
C29330	PR-52	Retired_Concepts	PR-52
C29331	PR18_ras-12CYS_Peptide	Mutated_Ras_Peptide	PR18 (ras-12CYS) Peptide|Ras Peptide PR18 (YKLVVVGACGVGKSALT)	A synthetic form of the ras peptide containing a point mutation at position 12 (glycine to cysteine). Vaccines using mutant ras peptides may be used in the immunotherapy of various cancers that express ras mutations. (NCI04)
C29332	Pregn-4-ene_Trione	Therapeutic_Progestin	Pregn-4-ene Trione|6alpha-Methyl-11-oxoprogesterone|6alpha-Methylpregn-4-ene-3,11,20-trione|SKI 22936|U 7654	The basic, partial chemical structure of corticosteroid hormones such as cortisone and aldosterone. (NCI04)
C29333	Prospidin	DNA_Adduct_Forming_Agent|Immunosuppressant	Prospidin|3,12-Diaza-6,9-diazoniadispiro(5.2.5.2)hexadecane, 3,12-bis(3-chloro-2-hydroxypropyl)-, dichloride|Prospidine|Prospidium|Prospidium Chloride	An dispiropiperazine derivative with potential cytostatic, anti-inflammatory and immune-suppressive properties.  Although the exact mechanism of action of prospidin is not known, this agent was shown to interact with DNA, disrupting cell cycle at G2 phase, inhibiting phagocytic activity of monocytes and macrophage.  Prospidin has good anti-lupus activity due to its immunosuppressive effects and was also used in refractory rheumatoid arthritis as an anti-rheumatic drug. (NCI04)
C29334	PROSTVAC-CONTAMINATED_W_BVDV	Vaccinia_Prostate_Specific_Antigen_Vaccine	PROSTVAC-Contaminated W/ BVDV
C29335	PS_IL-10	Retired_Concepts	PS IL-10
C29336	PS_IL-10_Placebo	Clinical_Study_Element	PS IL-10/Placebo
C29337	PSA-OP_Peptide_Vaccine	Antineoplastic_Vaccine	PSA-OP Peptide Vaccine	A 30-residue prostate specific antigen (PSA) oligoepitope peptide (OP) vaccine with potential antineoplastic activity.  PSA-OP peptide vaccine contains the PSA-1 and PSA-3 HLA-A2 epitopes and the PSA-9 HLA-class I-A3 epitope joined by peptide linker sequences.  In an animal model, vaccination with this agent has been shown to elicit a cytotoxic T-lymphocyte immune response. (NCI04)
C29338	PSA_154-163_155L_PSA-3A	Vaccine_Antigen	PSA:154-163 Peptide Vaccine|PSA PEP VAC|PSA:154-163(155L) [PSA-3A]	A cancer vaccine comprised of a synthetic peptide with an amino acid sequence corresponding to positions 154-163 of the amino acid sequence for prostate-specific antigen (PSA) with potential antineoplastic activity. Upon administration, PSA:154-163 peptide vaccine may elicit a cytotoxic T-cell response against tumor cells that express PSA. (NCI05)
C29339	Small_Inducible_Cytokine-B6	Alpha_Chemokine	Small Inducible Cytokine B6|CKA-3|CXCL6|Chemokine (C-X-C Motif) Ligand 6|Chemokine Alpha 3|GCP-2|Granulocyte Chemotactic Protein 2|Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member 6|Small Inducible Cytokine Subfamily B (Cys-X-Cys), Member B	Encoded by human CXCL6 Gene (Intercrine Alpha/Chemokine CXC Family), secreted 114-aa 12-kD (precursor) Small Inducible Cytokine B6 is a potent inflammatory mediator and chemotactic factor for neutrophilic granulocytes that regulates leukocyte trafficking through interactions with a subset of 7-transmembrane, G protein-coupled receptors CXCR1 and CXCR2 and activates gelatinase B (MMP9) release from granulocytes. Human and bovine GCP2 are 67% identical at the amino acid level. (NCI)
C29340	PSMA_Peptide	Vaccine_Antigen	PSMA Peptide
C29341	PT523	Dihydrofolate_Reductase_Inhibitor|Folate_Antagonist	Talotrexin|PT523	An antimetabolite analog of aminopterin with antineoplastic activity.  As a folate antagonist, PT523 binds to and inhibits the function of dihydrofolate reductase.  Hydrosoluble, PT523 is actively transported into cells by the reduced folate carrier (RFC) and, therefore, is unlikely to be associated with P-glycoprotein-mediated multidrug resistance. (NCI04)
C29342	PTF	Retired_Concepts	PTF
C29343	Pyran_Polymer	Conjugating_Agent	Pyran Polymer	A hydrocarbon-based polymer containing a pyran nucleus used to bioconjugate various drugs,. Use of a pyran polymer-drug bioconjugate may alter the biodistribution of a low molecular weight drug, resulting in disease-specific targeting with reduced drug access to sites of toxicity such as the bone marrow; the large size of the bioconjugate does not allow the active agent to pass the blood-bone marrow barrier. (NCI04)
C29344	Pyrazole_Imidazole	Miscellaneous_Antimetabolite|Ribonucleotide_Reductase_Inhibitor	Imidazole-Pyrazole|2,3-Dihydro-1H-imidazo(1,2-b)pyrazole|BRN 0742753|IMPY|Imidazolepyrazole|Pyrazole Imidazole	A synthetic agent, also known as IMPY, with antineoplastic properties.  IMPY inhibits ribonucleotide reductase, an enzyme that converts ribonucleotides to deoxyribonucleotides during DNA synthesis; this agent specifically binds the smaller, nonheme-iron subunit of the enzyme. (NCI04)
C29345	Pancrelipase	Enzyme_Replacement_Preparation	Pancrelipase|Pancrease
C29346	Pantoprazole	Proton_Pump_Inhibitor	Pantoprazole
C29348	Pegfilgrastim_Neulasta	Retired_Concepts	Pegfilgrastim (Neulasta)
C29349	Pentamidine_Isethionate	Pentamidine	Pentamidine Isethionate|PENTAMIDINE ISETHIONATE|Pentacarinat|Pentam	A synthetic amidine derivative, Pentamidine Isethionate is an antiprotozoal and antifungal agent that appears to interact with the minor groove of AT-rich DNA regions of the pathogen genome, interfering with DNA replication and function. It is effective in the treatment of trypanosomiasis, leishmaniasis, some fungal infections, and Pneumocystis carinii pneumonia in HIV-infected patients. (NCI04)
C29350	Pentosan	Retired_Concepts	Pentosan
C29351	Percocet	Analgesic_Preparation	Percocet
C29352	Peri-Colace	Retired_Concepts	Peri-Colace
C29353	Peripheral_Stem_Cell_Transplant	Biological_Agent	Peripheral Stem Cell Transplant	A method of hematopoietic reconstitution, Peripheral Stem Cell Transplants utilize (transfuse) hematopoietic stem cells harvested from circulating blood of an autologous, syngeneic, or allogeneic donor to reconstitute the bone marrow of the transplant recipient. Peripheral stem cell transplants are performed following partial or complete bone marrow ablation of a patient, done as therapy for certain blood diseases or following high dose chemotherapy or radiation treatment for cancer. (NCI04)
C29354	Permethrin	Pediculocide	Permethrin
C29355	Perphenazine	Antipsychotic_Agent	Perphenazine|4-[3-(2-Chloro-10H-phenothiazin-10-yl)propyl]-1-piperazineethanol|PERPHENAZINE
C29356	Petrolatum_Hydrophilic	Drug_Vehicle	Petrolatum Hydrophilic
C29357	Phenazopyridine	Nonnarcotic_Analgesic	Phenazopyridine	A synthetic pyridine derivative anesthetic, Phenazopyridine is used as a local anesthetic in urinary tract disorders to relieve pain of lower urinary-tract irritation, as in cystitis, urethritis or prostatitis. Compatible with relief of pain and discomfort in antibacterial therapy, its use is limited however due to toxicity (primarily blood disorders) and potential carcinogenicity. (NCI04)
C29358	Pheniramine_Maleate	Histamine-1_Receptor_Antagonist	Pheniramine Maleate|PHENIRAMINE MALEATE
C29359	Phenolphthalein	Laxative	Phenolphthalein
C29360	Phenoxymethylpenicillin	Retired_Concepts	Phenoxymethylpenicillin
C29361	Phentermine_Hydrochloride	Anorexiant	Phentermine Hydrochloride|PHENTERMINE HYDROCHLORIDE|Phentermine HCl
C29362	Phenylephedrine_Phenylpropanolamine_Guaifenesin	Cough_and_Cold_Preparation	Phenylephrine/Phenylpropanolamine/Guaifenesin|Phenylephed/Phenylprop/Guaifen
C29363	Phenylephrine	Alpha-adrenergic_Agonist	Phenylephrine Hydrochloride|PHENYLEPHRINE HYDROCHLORIDE|Phenylephrine
C29364	Phenylpropanolamine	Alpha-adrenergic_Agonist	Phenylpropanolamine
C29365	Phytonadione	Vitamin_K	Phytonadione	An analogue of the napthoquinone vitamin K found in plants.  The vitamins K are essential for blood coagulation as it is necessary for the hepatic synthesis of the coagulation factors II, VII, IX, and X; deficiency results in a bleeding diathesis. These vitamins are lipo-soluble; absorption via intestinal lymphatics requires the presence of bile salts. (NCI04)
C29366	Pimonidazole_Hydrochloride	Pimonidazole	Pimonidazole Hydrochloride	A substituted nitroimidazole salt.  Hypoxic cells bioreductively activate and bind pimonidazole. This agent may be used as a hypoxia marker for detecting oxygen gradients in living tissues. Pimonidazole also exhibits radiosensitizing properties. (NCI04)
C29367	Pioglitazone	Anti-diabetic_Agent	Pioglitazone Hydrochloride|Actos|PIOGLITAZONE HYDROCHLORIDE|Pioglitazone	An orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity. Pioglitazone activates peroxisome proliferator-activated receptor gamma (PPAR-gamma), a ligand-activated transcription factor, thereby inducing cell differentiation and inhibiting cell growth and angiogenesis. This agent also modulates the transcription of insulin-responsive genes, inhibits macrophage and monocyte activation, and stimulates adipocyte differentiation. (NCI05)
C29368	Podofilox	Tubulin_Binding_Agent	Podofilox|PODOFILOX	A pure, stabilized form of podophyllin, in which only the biologically active portion of the compound is present.  Podophyllotoxin is a toxic, polycyclic antimitotic agent isolated primarily from the rhizome of the plant Podophyllum peltatum. This agent is formulated for topical applications. (NCI04)
C29369	Polycitra	Alkalinizing_Agent_Preparation	Polycitra
C29370	Polyvinyl_Alcohol	Drug_Vehicle	Polyvinyl Alcohol|PVA|Polyvinyl Alcohol (PVA)
C29371	Polyvinyl_Alcohol_PVA	Retired_Concepts	Polyvinyl Alcohol (PVA)|Polyvinyl Alcohol PVA
C29372	Potassium_Citrate	Electrolyte_Replacement_Agent	Potassium Citrate|2-Hydroxy-1,2,3-propanetricarboxylic Acid, Potassium Salt|POTASSIUM CITRATE
C29373	Potassium_Phosphate	Electrolyte_Replacement_Agent	Potassium Phosphate|Potassium phosphate
C29374	Pramipexole_Dihydrochloride	Antiparkinsonian_Agent	Pramipexole Dihydrochloride|PRAMIPEXOLE DIHYDROCHLORIDE	The hydrochloride salt of pramipexole, a benzothiazole derivative. As a nonergot dopamine agonist, pramipexole binds to D2 and D3 dopamine receptors in the striatum and substantia nigra of the brain. Compared to other dopamine agonists, the use of this agent may be associated with fewer dyskinetic side effects in treated subjects. (NCI04)
C29375	Pravastatin	HMG-CoA_Reductase_Inhibitor	Pravastatin Sodium|PRAVASTATIN SODIUM|Pravastatin|[1S-[1alpha(betaS*,!dS*),2alpha,6alpha,8beta(R*),8aalpha]]-1,2,6,7,8,8a-Hexahydro-beta,!d,6-trihydroxy-2-methyl-8-(2-methyl-1-oxobutoxy)-1-naphthaleneheptanoic Acid	A synthetic lipid-lowering agent.  Pravastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis.  Pravastatin lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)
C29376	Etoposide_Prednisone	Chemotherapy_Regimen	Etoposide/Prednisone|Prednisone/Etoposide
C29377	Prempro	Hormone_Replacement_Preparation	Prempro
C29378	Preparation_H	Hemmorrhoidal_Preparation	Preparation H
C29379	Probenecid_Colchicine	Antigout_Preparation	Probenecid/Colchicine
C29380	Proctofoam	Hemmorrhoidal_Preparation	Proctofoam
C29382	Propranolol_Hydrochloride	Beta-Adrenergic_Blocking_Agent	Propranolol Hydrochloride|1-[(1-Methylethyl)amino]-3-(1-naphthalenyloxy)-2-propanol|2-Propanol-1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy) Hydrochloride|Inderal|PROPRANOLOL HYDROCHLORIDE|Propranolol	A beta-adrenergic receptor blocker.  Propranolol competitively binds to beta-adrenergic receptors, resulting in a decrease in beta-adrenergic stimulation, vasodilation, and negative chronotropic and inotropic effects. (NCI04)
C29383	Propantheline_Bromide	Antimuscarinic_Agent	Propantheline Bromide|PROPANTHELINE BROMIDE
C29384	Propofol	Sedative_and_Hypnotic	Propofol|Diprivan|PROPOFOL|Propofol/Diprivan	A hypnotic alkylphenol derivative. Formulated for intravenous induction of sedation and hypnosis during anesthesia, propofol facilitates inhibitory neurotransmission mediated by gamma-aminobutyric acid (GABA. This agent is associated with minimal respiratory depression and has a short half-life with a duration of action of 2 to 10 minutes. (NCI04)
C29385	Propoxyphene_Hydrochloride	Opioid	Propoxyphene Hydrochloride|Propoxyphene HCl	A synthetic diphenyl propionate derivative structurally related to methadone, Propoxyphene Hydrochloride acts as a central narcotic and analgesic agent by interaction with mu opioid receptors, but with less selectivity then morphine. The dextro-isomer has analgesic effect, while the levo-isomer exerts an antitussive effect. (NCI04)
C29386	Propoxyphene_Napsylate	Opioid	Propoxyphene Napsylate|PROPOXYPHENE NAPSYLATE	A synthetic diphenyl propionate derivative structurally related to methadone, Propoxyphene Napsylate acts as a central narcotic and analgesic agent by interaction with mu opioid receptors, but with less selectivity then morphine. The dextro-isomer has analgesic effect, while the levo-isomer exerts an antitussive effect. The napsylate salt allows better dosage formulation than the hydrochloride salt. (NCI04)
C29387	Propoxyphene_Napsylate-Acetaminophen	Analgesic_Preparation	Propoxyphene Napsylate/Acetaminophen|Darvocet
C29388	Propylene_Glycol	Drug_Vehicle	Propylene Glycol|1,2-Dihydroxypropane|1,2-Propanediol|PEG
C29389	Propyllin_CCC	Topical_Preparation	Prophyllin CCC|Propyllin CCC
C29390	Pseudoephedrine_Hydrochloride	Alpha-adrenergic_Agonist	Pseudoephedrine Hydrochloride|PSEUDOEPHEDRINE HYDROCHLORIDE|Pseudoephedrine HCl|Pseudoephedrine.HCl
C29391	Pseudophedrine_Sulfate	Retired_Concepts	Pseudoephedrine Sulfate
C29392	Pseudophedrine_Loratadine	Retired_Concepts	Pseudophedrine/Loratadine
C29393	Psyllium	Retired_Concepts	Psyllium
C29394	Pyazoloacidine	Retired_Concepts	Pyrazoloacridine
C29395	Pyrazinamide	Antitubercular_Agent	Pyrazinamide|PYRAZINAMIDE	A synthetic pyrazinoic acid amide derivative, bactericidal tuberculostatic Pyrazinamide is particularly active against slowly multiplying intracellular bacilli (unaffected by other drugs) by an unknown mechanism of action. Its bactericidal action is dependent upon the presence of bacterial pyrazinamidase, which removes the amide group to produce active pyrazinoic acid. Pyrazinamide is an important component of multidrug therapy for tuberculosis. (NCI04)
C29396	Pyrazole	Heterocyclic_Compound	Pyrazole	A class of heterocyclic organic compounds characterized by a ring structure composed of three carbon atoms and two nitrogen atoms in adjacent positions. The simplest member of this chemical class is pyrazole itself, a compound with the molecular formula C3H4N2.  Depending on the chemical substitutions present, pyrazoles exhibit a variety of pharmacological properties, including those anti-inflammatory, anti-psychotic, antibiotic and anti-enzymatic. Some pyrazole derivatives are tubulin inhibitors with antiangiogenic and antineoplastic properties. (NCI04)
C29398	Quinapril	ACE_Inhibitor	Quinapril Hydrochloride|QUINAPRIL HYDROCHLORIDE|Quinapril	A non-sulfhydryl-containing non-peptide with antihypertensive activity.  As a prodrug, quinapril is hydrolized into its active form quinaprilat.  Quinaprilat inhibits angiotensin converting enzyme, thereby blocking the conversion of angiotensin I to angiotensin II, decreasing aldosterone secretion, increasing bradykinin levels and ultimately causing vasodilation. (NCI)
C29399	Quinine_Sulfate	Quinine	Quinine Sulfate	The sulfate salt form of the quinidine alkaloid isolate quinine. Quinine has many mechanisms of action, including reduction of oxygen intake and carbohydrate metabolism; disruption of DNA replication and transcription via DNA intercalation; and reduction of the excitability of muscle fibers via alteration of calcium distribution.  This agent also inhibits the drug efflux pump P-glycoprotein which is overexpressed in multi-drug resistant tumors and may improve the efficacy of some antineoplastic agents. (NCI04)
C29400	Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Vincristine_R-Verapamil	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Prednisone/Vincristine/R-Verapamil|R-Verap/EPOCH
C29401	RASVAC-C	Antineoplastic_Vaccine	RASVAC-C	A synthetic vaccine used for cancer immunotherapy also known as Ras(cis 12)-Vaccinia Vaccine, RASVAC-C is based on a mutant peptide epitope of the Ras oncoprotein at codon 12 that induces recognition and induction of tumor-specific, cell-mediated immune responses. Ras is an intracellular GTP-binding protein involved in signal transduction and regulation of proliferation and differentiation. (NCI04)
C29402	RASVAC-V	Antineoplastic_Vaccine	RASVAC-V	A synthetic vaccine used for cancer immunotherapy also known as Ras(val 12)-Vaccinia Vaccine, RASVAC-C is based on a mutant peptide epitope of the Ras oncoprotein at codon 12 (valine instead of glycine) that induces recognition and induction of tumor-specific, cell-mediated immune responses. Ras is an intracellular GTP-binding protein involved in signal transduction and regulation of proliferation and differentiation. (NCI04)
C29404	RH1	Miscellaneous_Alkylating_Agent	RH1	An alkylating aziridinylbenzoquinone with potential antineoplastic activity.  Activated by NAD(P)H: quinone acceptor oxidoreductase 1 (NQO1), RH1 induces interstrand DNA crosslinks in tumor cells that express NQO1, thereby irreversibly damaging DNA and resulting in cell death. (NCI04)
C29405	Rhizoxin_Diluent	Drug_Vehicle	Rhizoxin Diluent
C29406	Rifamycin	Antitubercular_Agent	Rifamycin	A natural antibiotic produced by Streptomyces mediterranei, Rifamycin (Ansamycin Family) is a commonly used antimycobacterial drug that inhibits prokaryotic DNA-dependent RNA synthesis and protein synthesis; it blocks RNA-polymerase transcription initiation. Rifamycin has an activity spectrum against Gram-positive and Gram-negative bacteria, but is mainly used against Mycobacterium sp. (especially M. tuberculosis) in association with other agents to overcome resistance. (NCI04)
C29407	RTGF-Beta	Retired_Concepts	RTGF-Beta
C29408	RV-B7_RECOMB_VACCINIA_B7	Retired_Concepts	RV-B7 (RECOMB VACCINIA/B7)
C29409	Recombinant_Vaccinia-MUC-1_B7	Vaccinia_Vaccine	Recombinant Vaccinia-MUC1-B7|MUC1-B7-Vaccinia Vaccine|RV-MUC-1/B7 (Recomb Vaccinia)|Recombinant Vaccinia-MUC1-B7.1|rV-MUC1-B7.1	An admixture of recombinant vaccinia virus encoding MUC-1 and recombinant vaccinia virus encoding the murine T-cell co-stimulatory molecule B7.1.  MUC-1 is a glycosylated mucin that is overexpressed in breast, lung, pancreatic, prostate, stomach, colon, and ovarian carcinomas.  Vaccination with MUC-1 in combination with B7.1 may enhance the cytotoxic T cell (CTL) immune response to tumors expressing MUC-1, compared to vaccination with MUC-1 alone. (NCI04)
C29410	Rabeprazole	Proton_Pump_Inhibitor	Rabeprazole Sodium|RABEPRAZOLE SODIUM|Rabeprazole
C29411	Ramipril	ACE_Inhibitor	Ramipril|RAMIPRIL	A non-sulfhydryl-containing substance with antihypertensive activity.  As a prodrug, ramipril is converted by de-esterification into its active form ramiprilat.  Ramiprilat inhibits angiotensin converting enzyme, thereby blocking the conversion of angiotensin I to angiotensin II, decreasing aldosterone secretion, increasing bradykinin levels and ultimately causing vasodilation. (NCI)
C29412	Ranitidine	Histamine-2_Receptor_Antagonist	Ranitidine|N-[2-[[[5-[(Dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-1,1-ethenediamine|Ranitidine Hydrochloride|Ranitidine.HCl|Zantac
C29413	Refresh_PM_Lubricant	Topical_Preparation	Refresh PM Lubricant
C29414	Replens	Topical_Preparation	Replens
C29415	Murine_MCA_Ricin_Conjugate	Ricin_Immunoconjugate	Murine MCA Ricin Conjugate|Ricin Conjug. Murine MCA	An immunotoxin consisting of a murine monoclonal antibody (MCA) conjugated to the toxin ricin. The monoclonal antibody component binds to cell surface antigens, thereby targeting delivery of cytotoxic ricin to a specific cell type. The ricin component binds to cells and disrupts ribosomal activity and protein synthesis and induces cell cycle arrest. (NCI04)
C29416	Risperidone	Antipsychotic_Agent	Risperidone|RISPERIDONE
C29417	Sangivamycin_Hydrochloride	Miscellaneous_Antineoplastic_Antibiotic|Protein_Kinase_C_Inhibitor	Sangivamycin Hydrochloride|Sangivamycin HCl	The salt of a deaza-adenosine antibiotic isolated from the bacterium Streptomyces rimosus with potent cytotoxic properties.  Sangivamycin inhibits protein kinase C (PKC), a signaling mediator important for cell growth and differentiation.  This agent may also interfere with protein synthesis by inhibiting the formation of complexes essential to the initiation of protein synthesis and DNA synthesis. (NCI04)
C29418	SBIL-2	Viral_Vector-Gene_Complex	SBIL-2
C29419	SCAB	Retired_Concepts	SCAB
C29420	Shared_Anti-Idiotype-AB-S002	Monoclonal_Antibody	Shared Anti-Idiotype AB-S002	A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)
C29421	Shared_Anti-Idiotype-AB-S003	Monoclonal_Antibody	Shared Anti-Idiotype-AB-S003	A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)
C29422	Shared_Anti-Idiotype-AB-S004	Monoclonal_Antibody	Shared Anti-Idiotype-AB-S004	A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)
C29423	Shared_Anti-Idiotype-AB-S005	Monoclonal_Antibody	Shared Anti-Idiotype-AB-S005|Shared Anti-Idiotype AB-S005	A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)
C29424	Shared_Anti-Idiotype-AB-S006	Monoclonal_Antibody	Shared Anti-Idiotype-AB-S006|Murine Monoclonal Antibody To Human B Cell Lymphomas (Anti- Idiotypes) (S006)|Shared Anti-Idiotype AB-S006	A murine monoclonal anti-idiotype antibody that targets human B-cell lymphomas with potential antineoplastic activity.  Shared Anti-Id-Ab-S006 binds to antigens on neoplastic B cells, resulting in tumor cell destruction by the reticuloendothelial system or cytotoxic T lymphocytes (CTL). (NCI04)
C29425	Shared_Anti-Idiotype-AB-S008A	Monoclonal_Antibody	Shared Anti-Idiotype-AB-S008A|Shared Anti-Idiotype AB-S008A	A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)
C29426	Shared_Anti-Idiotype-AB-S011A	Monoclonal_Antibody	Shared Anti-Idiotype-AB-S011A|Shared Anti-Idiotype AB-S0011A	A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)
C29427	Shared_Anti-Idiotype-AB-S012	Monoclonal_Antibody	Shared Anti-Idiotype-AB-S012|Shared Anti-Idiotype AB-S0012	A monoclonal antibody directed against a specific tumor-associated antigen (TAA).  (NCI04)
C29428	Shared_Anti-Idiotype-AB-S016	Monoclonal_Antibody	Shared Anti-Idiotype-AB-S016	A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)
C29429	Shared_Anti-Idiotpe-AB-S017	Monoclonal_Antibody	Shared Anti-Idiotype-AB-S017	A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)
C29430	Shared_Anti-Idiotype-AB-S018	Monoclonal_Antibody	Shared Anti-Idiotype-AB-S018	A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)
C29431	Shared_Anti-Idiotype-AB-S021A	Monoclonal_Antibody	Shared Anti-Idiotype-AB-S021A	A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)
C29432	Shared_Anti-Idiotype-AB-S024A	Monoclonal_Antibody	Shared Anti-Idiotype-AB-S024A
C29433	Shared_Anti-Idiotype-AB-S025	Monoclonal_Antibody	Shared Anti-Idiotype-AB-S025	A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)
C29434	Shared_Anti-Idiotype-AB-S027	Monoclonal_Antibody	Shared Anti-Idiotype-AB-S027	A monoclonal antibody directed against a specific tumor-associated antigen (TAA). (NCI04)
C29435	SJG-136	DNA_Crosslinking_Agent|DNA_Minor_Groove_Binding_Agent	SJG-136|SJG136	A pyrrolobenzodiazepine dimer with potential antineoplastic activity. SJG-136 binds to the minor groove of DNA and induces interstrand cross-links between two N-2 guanine positions, thereby inhibiting DNA replication and transcription. With a preference for binding to purine-GATC-pyrimidine sequences, SJG-136 adducts do not appear to be subject to p53-mediated DNA excision repair mechanisms. (NCI05)
C29436	SPI-77	Retired_Concepts	SPI-77
C29437	SS1_dsFv_PE38	Retired_Concepts	SS1(dsFv) PE38
C29438	STAMP	Retired_Concepts	STAMP
C29439	Steroid_Suspending_Vehicle	Drug_Vehicle	Steroid Suspending Vehicle|Steroid Suspending VEH
C29440	Stilbene_Aldehyde	Industrial_Aid	Stilbene Aldehyde	An organic derivative of the unsaturated hydrocarbon stilbene, an aromatic alkene that is the nucleus of diethylstilbestrol and related compounds. Stilbene aldehyde is used in the chemical synthesis of estrogenic agents as well as for the manufacture of research reagents such as trans-stilbene oxide, a substrate for glutathione S-transferase.  Estrogenic compounds containing the stilbene nucleus are known to be carcinogenic in humans and animals.  (NCI04)
C29441	Salicylic_Acid-Sulfur	Topical_Preparation	Salicylic Acid/Sulfur
C29442	Salivart	Topical_Preparation	Salivart
C29443	Salmeterol	Bronchodilator	Salmeterol
C29444	Saquinavir	Protease_Inhibitor	Saquinavir|Fortovase|SAQUINAVIR	A synthetic antiviral agent.  Saquinavir, a peptide-like substrate, selectively binds to and inhibits human immunodeficiency virus (HIV) protease, thereby preventing cleavage of the gag-pol viral polyprotein and resulting in the release of immature, noninfectious virions. (NCI04)
C29445	Sarna	Topical_Preparation	Sarna
C29446	Scopolamine_Hydrobromide	Antiemetic_Agent|Mydriatic_Agent	Scopolamine Hydrobromide
C29447	Senna_Fruit	Fruit_and_Vegetable	Senna Fruit	The fruit of C. acutifolia and C. angustifolia (Cassia), Senna Fruit is used as a laxative or purgative in many pharmacological preparations. A sulphur-containing glucoside, the main active ingredient is calcium and magnesium salts of cathartic acid. Senna stimulates the bowel muscular coat, particularly in the colon. In most patients, the drug has the advantage of not producing subsequent constipation. (NCI04)
C29448	Sennosides	Laxative	Sennosides|Nature's Remedy
C29449	Senokot	Laxative	Senokot
C29450	Senokot-S	Laxative_Preparation	Senokot-S
C29451	Sertraline_Hydrochloride	Antidepressant_Agent	Sertraline Hydrochloride|SERTRALINE HYDROCHLORIDE|Sertraline HCl|Zoloft	The salt form of a synthetic derivative of naphthalenamine with anti-serotoninergic and anti-depressant properties. Sertraline appears to selectively inhibit the neuronal uptake of serotonin, raising serotonin levels in the CNS. (NCI04)
C29452	Silenafil_Citrate	Retired_Concepts	Silenafil Citrate
C29453	Simethicone	Antiflatulent_Agent	Simethicone
C29454	Simvastatin	HMG-CoA_Reductase_Inhibitor	Simvastatin|MK 733|SIMVASTATIN|Synvinolin|Zocor|[1S-[1alpha,3alpha,7beta,8beta(2S*,4S*),8abeta]]-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl 2,2-dimethylbutanoate	A lipid-lowering agent derived synthetically from a fermentation product of the fungus Aspergillus terreus.  Hydrolyzed in vivo to an active metabolite, simvastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis.  This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing MHC II (major histocompatibility complex II) on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. (NCI04)
C29455	Sinucleanse_Kit	Cough_and_Cold_Preparation	Sinucleanse Kit
C29456	Skelex	Muscle_Relaxant_Preparation	Skelex	A recombinant vaccinia virus that encodes granulocyte-macrophage colony stimulating factor (GM-CSF).  By activating T-cells and macrophages, vaccination with recombinant vaccinia GM-CSF may enhance the host immune system response to poorly immunogenic tumors, resulting in decreased tumor growth. (NCI04)
C29457	Sodium_Bicarbonate	Electrolyte_Replacement_Agent	Sodium Bicarbonate|SODIUM BICARBONATE
C29458	Sodium_Cromoglycate	Retired_Concepts	Sodium Cromoglycate
C29459	Sodium_Phosphorus	Electrolyte_Replacement_Agent	Sodium Phosphate|Sodium Phosphorus
C29460	Sodium_Polystrene	Retired_Concepts	Sodium Polystyrene
C29461	Sodium_Polystyrene_Sulfonate	Electrolyte_Replacement_Agent	Sodium Polystyrene Sulfonate|Kayexalate|Sodium Polystrene|Sodium Polystyrene	A potassium ion exchange resin composed of benzene-diethyl polymer with ethenyl-benzene, sulfonated, sodium salt. Administered as an oral suspension, sodium polystyrene sulfonate lowers serum potassium levels by exchanging its sodium ions for potassium ions. Acting primarily in the large intestine, this agent also exchanges its sodium ions for calcium and magnesium ions, resulting in a decrease in serum calcium and magnesium levels. (NCI04)
C29462	Sorbitol	Artificial_Sweetener	Sorbitol|SORBITOL
C29463	Sotalol_Hydrochloride	Beta-Adrenergic_Blocking_Agent	Sotalol Hydrochloride|Betapace|SOTALOL HYDROCHLORIDE|Sotalol HCl
C29464	StudyMed_00C0080	Clinical_Study_Element	StudyMed 00C0080
C29465	StudyMed_98C0118	Clinical_Study_Element	StudyMed 98C0118
C29466	Succinylated_Dimer_Form_of	Retired_Concepts	Succinylated Dimer Form of
C29467	Sulfacetamide	Sulfonamide_Anti-infective_Agent	Sulfacetamide Sodium|SULFACETAMIDE SODIUM|Sulfacetamide	A synthetic sulfanylacetamide derivative, bacteriostatic Sulfacetamide inhibits bacterial folic acid synthesis by competing with para amino benzoic acid. With a broad spectrum of action, it is used as an anti-infective topical agent to treat skin infections and as an oral agent for urinary tract infections. (NCI04)
C29468	Sulfadiazine	Sulfonamide_Anti-infective_Agent	Sulfadiazine|SULFADIAZINE	A synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing with para amino benzoic acid. It is used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. (NCI04)
C29469	Sulfasalazine	Sulfonamide_Anti-infective_Agent	Sulfasalazine|2-Hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]azo]benzoic Acid|Azulfidine|SULFASALAZINE|Salazosulfapyridine|Sulphasalazine	A synthetic salicylic acid derivative with affinity for connective tissues containing elastin and formulated as a prodrug, antiinflammatory Sulfasalazine acts locally in the intestine through its active metabolites, sulfamide 5-aminosalicylic acid and salicylic acid, by a mechanism that is not clear. It appears inhibit cyclooxygenase and prostaglandin production and is used in the management of inflammatory bowel diseases. (NCI04)
C29470	Sumatriptan_Succinate	Sumatriptan	Sumatriptan Succinate|SUMATRIPTAN SUCCINATE
C29471	Aminoglutethimide_Hydrocortisone_Suramin	Chemotherapy_Regimen	Aminoglutethimide/Hydrocortisone/Suramin|Suramin/AGT/HC
C29472	Flutamide_Hydrocortisone_Suramin	Chemotherapy_Regimen	Flutamide/Hydrocortisone/Suramin|Suramin/HC/Flut
C29473	Swiss_Kiss	Retired_Concepts	Swiss Kiss
C29474	Synerlip_p53	Non-Viral_Vector-Gene_Complex	Synerlip p53|Synerlip p53 Liposome
C29475	TAS-106	Pyrimidine_Antagonist|RNA_Polymerase_Inhibitor	TAS-106|1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine	A synthetic pentofuranosyl analog of cytosine with antineoplastic properties.  As a fraudulent substrate, TAS-106 inhibits ribonucleic acid (RNA) synthesis by substituting for cytosine as a substrate for ribonucleoside- and ribonucleotide-metabolizing enzymes such as RNA polymerase, resulting in decreased cellular RNA pools and proteins, and cell death.  TAS-106 exhibits a broad spectrum of antitumor activity. (NCI04)
C29476	TBC-CEA_Contaminated_w_BVDV	Vaccinia_CEA_Vaccine	TBC-CEA-Contaminated W/ BVDV	A cancer vaccine consisting of a recombinant vector encoding the tumor-associated carcinoembryonic antigen (CEA) that is contaminated with bovine viral diarrhea virus (BVDV). The carcinoembryonic antigen (CEA) is a prevalent tumor marker expressed by a number of different cancers such as colorectal, breast, lung and ovarian carcinomas; vaccination with vaccinia virus genetically engineered to express CEA may generate antitumoral T-cell responses. BVDV is an RNA pestivirus that may contaminate vaccines due to its presence in fetal calf serum used as a growth supplement in the tissue culture of mammalian cells used in vaccine production. (NCI04)
C29477	THYMOSIN_FRACTION_5	Retired_Concepts	Thymosin Fraction 5
C29478	Tumor_Infiltrating_Lymphocytes-N2-Transduced	Biological_Agent	Tumor Infiltrating Lymphocytes-N2-Transduced|TI Lymphs-N2-Transduced	A preparation of lymphocytes harvested from a patient and genetically modified ex vivo for use in gene therapy for the patient's cancer.  Ex vivo, the lymphocytes are transduced with the N2 retroviral vector, which is modified to express a gene whose protein product either kills tumor cells or elicits specific anti-tumor immunity. Genetically modified lymphocytes are infused back into the patient from whom they were harvested, locate to the tumor site, and express the candidate protein that kills tumor cells or stimulates host anti-tumor immunity. (NCI04)
C29479	TIL_TRANSDUCED_GENE_CODING_FOR_TNF	Retired_Concepts	TNF Gene Transduced TIL|TIL Transduced/Gene Coding for TNF	Tumor infiltrating lymphocytes (TIL) that are genetically modified in vitro to express the protein cytokine tumor necrosis factor (TNF) with potential antineoplastic activity. After isolation from the patient and genetic modification, TNF gene-transduced TIL are transferred back to the same patient in an attempt to deliver cytotoxic TNF selectively to the tumor microenvironment, thereby potentially avoiding TNF-related systemic toxicity. (NCI04)
C29480	Cisplatin_Dacarbazine_Interferon-alpha_Tamoxifen_Tumor-Infiltrating-Lymphocytes	Chemotherapy_Regimen	Cisplatin/Dacarbazine/Interferon-alpha/Tamoxifen/Tumor Infiltrating Lymphocytes|TIL/DTIC/Cisplat/Tam/IFN
C29481	Monoclonal_Antibody_T101_F_AB_2	Monoclonal_Antibody	Monoclonal Antibody T101 F(ab)2|T101 Monoclonal Antibody F(ab)2	A synthetic mouse monoclonal antibody which targets CD5+ lymphocytes.  Monoclonal antibody T101 may be used in the immunotherapy of T-cell malignancies.  Containing only the antigen-binding fragment of an immunoglobulin molecule, an FAB (fragment antibody) offers the advantages of smaller size and lower cross-reactivity compared to complete antibodies. (NCI04)
C29482	TNF_Transduced_TIL	Biological_Agent	TNF Transduced TIL|TIL Transduced/Gene Coding for TNF|TNF Gene Transduced TIL	A preparation of autologous tumor-infiltrating lymphocytes (TILs) that have been transduced with a retroviral vector encoding the gene for tumor necrosis factor (TNF), a cytokine with anti-angiogenic and cytotoxic activity.  Following genetic modification, the lymphocytes are returned to the patient, infiltrate the tumor site, and deliver TNF directly to the tumor site, thereby exerting a specific antitumor effect, and avoiding TNF-related systemic toxicity. (NCI04)
C29483	TP-38	Immunotoxin	TGFa-PE38 Immunotoxin|Cervene|TP-38	A recombinant, chimeric toxin composed of human transforming growth factor alpha (TGF-alpha) fused to a fragment of Pseudomonas exotoxin (PE38) without its cell-binding domain.  The TGF-alpha moiety of the agent attaches to tumor cells expressing the epithelial growth factor receptor (EGFR); the exotoxin induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. (NCI04)
C29484	TPN	Nutritional_Support	Total Parenteral Nutrition|TPN	Total parenteral nutrition formulated for intravenous administration in patients who cannot eat or cannot get enough nutrients from the foods they eat.  It is a liquid mixture of proteins, carbohydrates, fats, vitamins, minerals and other nutrients.
C29485	Trimelamole	Ethylenimine_Compound	Trimelamol|BRN 4261541|Methanol, ((s-triazine-2,4,6-triyl)trimethyltrinitrilo)tri-|Trimethyloltrimethylmelamine	A synthetic derivative of trimethylmelamine with antineoplastic properties.  An analogue of siderophores (microbial iron chelators), trimelamol induces the formation of a reactive iminium species which may crosslink DNA. (NCI04)
C29486	Tamsulosin_Hydrochloride	Alpha-adrenergic_Blocking_Agent	Tamsulosin Hydrochloride|TAMSULOSIN HYDROCHLORIDE|Tamsulosin HCl
C29487	Tazarotene	Retinoic_Acid_Agent	Tazarotene|6-[(3,4-dihydro-4,4-dimethyl-2H-1-benzothiopyran-6-yl)ethynyl]- 3-Pyridinecarboxylic Acid, Ethyl Ester|AGN-190168|Avage|Ethyl 6-(2-(4,4-Dimethylthiochroman-6-yl)ethynyl)nicotinate|Renova|Retin-A MICRO|Retisol-A|Stieva-A|Stieva-A Forte|TAZAROTENE|Tazorac|Vitinoin	A synthetic, topical retinoid.  Tazarotene induces the expression of tazarotene-induced gene 3 (TIG3), a tumor suppressor gene.  In psoriasis, tazarotene normalizes abnormal keratinocyte differentiation and reduces their hyperproliferation. (NCI04)
C29488	Temezepam	Benzodiazepine	Temazepam|TEMAZEPAM|Temezepam
C29489	Tenecteplase	Recombinant_Tissue_Plasminogen_Activator	Tenecteplase|TNK-tPA|TNKase
C29490	Tenofovir	Reverse_Transcriptase_Inhibitor	Tenofovir	A synthetic antiviral acyclic nucleotide analogue of adenosine 5-monophosphate.  Tenofovir is incorporated into human immunodeficiency viral DNA instead of the natural substrate deoxyadenosine 5-triphosphate, thereby inhibiting HIV-1 reverse transcriptase (RT), an RNA-dependent DNA polymerase, and resulting in DNA chain termination and impairment of viral replication and propagation.  This agent prevents HIV from reproducing in uninfected cells only.  Tenofovir exhibits activity against the hepatitis B virus (HBV). (NCI04)
C29491	Terazosin_Hydrochloride	Alpha-adrenergic_Blocking_Agent	Terazosin Hydrochloride|Hytrin|TERAZOSIN HYDROCHLORIDE|Terazosin HCl
C29492	Terbinafine_Hydrochloride	Antifungal_Agent	Terbinafine Hydrochloride|(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethylamine Hydrochloride|Lamisil|TERBINAFINE HYDROCHLORIDE|Terbinafine HCl	A synthetic allylamine derivative structurally related to naftifine, antifungal Terbinafine Hydrochloride blocks ergosterol biosynthesis by inhibition of squalene epoxidase, part of the sterol synthesis pathway for the fungal cell membrane. Highly lipophilic, it tends to accumulate in skin, nails, and fatty tissues. Terbinafine is active against dermatophytes. (NCI04)
C29493	Terconzole	Antifungal_Agent	Terconazole|TERCONAZOLE	A synthetic triazole derivative structurally related to fluconazole, antifungal Terconazole seems to disrupt cell wall synthesis by inhibiting biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and promoting loss of essential intracellular elements.  Terconazole is active against Candida sp.. (NCI04)
C29494	Terfenadine	Histamine-1_Receptor_Antagonist	Terfenadine|Seldane|Teldane
C29495	Theraflu	Cough_and_Cold_Preparation	Theraflu
C29497	Thiethylperazine	Antiemetic_Agent	Thiethylperazine Maleate|THIETHYLPERAZINE MALEATE|Thiethylperazine
C29498	Thioridazine_Hydrochloride	Antipsychotic_Agent	Thioridazine Hydrochloride|THIORIDAZINE HYDROCHLORIDE|Thioridazine HCl
C29499	Thrombin	Miscellaneous_Adjuvant	Thrombin	A formulated therapeutic agent that contains endogenously produced thrombin isolated from human or animal plasma. (NCI04)
C29500	Tioconazole	Antifungal_Agent	Tioconazole|TIOCONAZOLE	A synthetic imidazole derivative, fungicidal Terconazole inhibits cell wall synthesis by inhibiting the biosynthesis of ergosterol or other sterols, damaging the fungal cell membrane, altering its permeability, and promoting loss of essential intracellular elements. Tioconazole is active against Candida sp.. (NCI04)
C29501	Timolol_Maleate	Beta-Adrenergic_Blocking_Agent	Timolol Maleate|TIMOLOL MALEATE
C29502	Tolazamide	Anti-diabetic_Agent	Tolazamide|TOLAZAMIDE
C29503	Tolmetin	Nonsteroidal_Antiinflammatory_Drug	Tolmetin	A synthetic non-steroidal anti-inflammatory agent with pyrrole structure, analgesic and antipyretic Tolmetin has a mode of action similar to indomethacin, but is less potent. Used in the treatment of rheumatoid arthritis, it inhibits prostaglandin synthetase and decreases production of inflammatory prostaglandin E. (NCI04)
C29504	Tolterodine	Antimuscarinic_Agent	Tolterodine Tartrate|TOLTERODINE TARTRATE|Tolterodine
C29505	Topical_Corticosteroids	Topical_Preparation	Topical Corticosteroids
C29506	Torsemide	Diuretic	Torsemide|TORSEMIDE
C29507	Tramadol	Opioid	Tramadol	A synthetic codeine analogue, Tramadol has central analgesic properties with effects similar to opioids, such as morphine and codeine, acting on specific opioid receptors. Used as a narcotic analgesic for severe pain, it can be addictive and weakly inhibits norepinephrine and serotonin reuptake. (NCI04)
C29508	Tramadol_Hydrochloride	Tramadol	Tramadol Hydrochloride|TRAMADOL HYDROCHLORIDE|Tramadol HCl|Ultram	A synthetic codeine analogue, Tramadol Hydrochloride has central analgesic properties with effects similar to opioids, such as morphine and codeine, acting on specific opioid receptors. The hydrochloride salt of Tramadol and used as a narcotic analgesic for severe pain, it can be addictive and weakly inhibits norepinephrine and serotonin reuptake. (NCI04)
C29509	Trastuzamab_Gemcitabine	Retired_Concepts	Gemcitabine/Trastuzumab|Gemcitabine/Trasbuzumab|Trastuzumab/Gemcitabine
C29510	Trazadone	Antidepressant_Agent	Trazodone	A synthetic triazolopyridine derivative, antidepressant and sedative Trazodone acts as a serotonin uptake inhibitor, chemically unrelated to tricyclic, tetracyclic, or other antidepressants. It is effective in patients with schizoaffective disorders; major depressive disorders; and depressive disorders associated with insomnia and anxiety. (NCI04)
C29511	TriGem	Monoclonal_Antibody	TriGem	An anti-idiotype monoclonal antibody that mimics the disialoganglioside GD2, a cancer-associated antigen present on melanoma, small cell lung cancer, sarcoma, neuroblastoma and other malignancies.  GD2 is a highly expressed glycosphingolipid by melanoma and other neuroectodermal tumors with only minimal expression on normal tissues.  TriGem induces an immune response and can be the base for immunotherapy of melanoma and other cancers. (NCI04)
C29512	Triaminic_AM_Cough_and_Decongestant	Cough_and_Cold_Preparation	Triaminic AM Cough and Decongestant|Triaminic AM Cough&Decongestant
C29513	Triaminic_AM_Decongestant	Cough_and_Cold_Preparation	Triaminic AM Decongestant
C29514	Triaminic_Cold	Cough_and_Cold_Preparation	Triaminic Cold
C29515	Triaminic_Cold_and_Allergy	Cough_and_Cold_Preparation	Triaminic Cold and Allergy|Triaminic Cold&Allergy
C29516	Triaminic_DM_Syrup	Cough_and_Cold_Preparation	Triaminic DM Syrup
C29517	Triaminic_Night_Time	Cough_and_Cold_Preparation	Triaminic Night Time
C29518	Triaminic_Syrup	Cough_and_Cold_Preparation	Triaminic Syrup
C29519	Triamterene	Diuretic	Triamterene|TRIAMTERENE
C29520	Triazolam	Benzodiazepine	Triazolam|TRIAZOLAM
C29521	Trilisate	Retired_Concepts	Trilisate
C29522	Trimethobenzamide_Hydrochloride	Antiemetic_Agent	Trimethobenzamide Hydrochloride|TRIMETHOBENZAMIDE HYDROCHLORIDE|Tigan|Trimethobenzamide HCl
C29523	Triptorelin_Pamoate	Triptorelin	Triptorelin Pamoate|6-D-Tryptophan-, 4,4'Mmethylenebis(3-hydroxy-2-naphthalenecarboxylate) (Salt)|Pamorelin|TRIPTORELIN PAMOATE|Trelstar Depot	The pamoate salt of triptorelin, a synthetic decapeptide agonist analog of luteinizing hormone releasing hormone (LHRH).  Possessing greater potency than endogenous LHRH, triptorelin reversibly represses gonadotropin secretion after prolonged administration.  After chronic, continuous administration, a sustained decrease in LH, FSH and testicular and ovarian steroidogenesis is observed.  The serum testosterone concentration may fall to levels typically seen in surgically castrated men. (NCI04)
C29524	Trisalicylate	Retired_Concepts	Trisalicylate
C29525	Tucks	Hemmorrhoidal_Preparation	Tucks
C29526	Tylenol_Sinus	Cough_and_Cold_Preparation	Tylenol Sinus
C29527	U-90	Retired_Concepts	U-90
C29528	Uniroyal_Compound	Anti-HIV_Agent	Uniroyal Compound|1-methylethyl-2-chloro-5-[[5,6-dihydro-2-methyl- 1, 4-oxathiin-3-yl-carbonyl]-amino]benzoate
C29529	UVB	Retired_Concepts	UVB
C29530	Undecyclenic_Acid	Antifungal_Agent	Undecylenic Acid|Cruex|Desinex	A natural or synthetic fungistatic fatty acid, antifungal Undecylenic Acid is used topically as a zinc salt in various creams against fungal infections, eczemas, ringworm, and other cutaneous conditions. The zinc provides an astringent action, reducing rawness and irritation. (NCI04)
C29531	Carbamide	Diuretic	Carbamide|Aqua Care|Elaqua XX|Lanaphilic|Nutraplus|UREA|Urea|Urea Carbamide|Ureaphil|Vanamide	As a natural compound and the chief solid component of mammalian urine, Carbamide (urea) is formed in the liver from ammonia by amino acid deamination as the principal end product of protein catabolism. Synthesized from ammonia and carbon dioxide, it is used as fertilizer, in animal feed, and in plastics. Intra-amniotic injection of urea is given to cause abortion. (NCI04)
C29532	Urised	Analgesic_Preparation	Urised
C29533	VAC0P	Retired_Concepts	VAC0P
C29534	VATH	Retired_Concepts	VATH
C29535	Valacyclovir_Hydrochloride	Valacyclovir	Valacyclovir Hydrochloride|VALACYCLOVIR HYDROCHLORIDE|Valacyclovir HCl	The hydrochloride salt of valacyclovir. Valacyclovir is an acyclovir prodrug that, after metabolization, inhibits viral DNA replication through interference with thymidine kinase. It is used in the management of herpes simplex and varicella zoster infections, as well as prophylactically for human cytomegalovirus infections. (NCI04)
C29536	Valproic_Acid	Anticonvulsant_Agent	Valproic Acid|2-Propylpentanoic Acid|2-Propylvaleric Acid|Depakene|Di-n-propylacetic Acid|VALPROIC ACID|Valproate	A synthetic derivative of propylpentanoic acid with antiepileptic properties and potential antineoplastic and antiangiogenesis activities.  In epilepsy, valproic acid appears to act by increasing the concentration of gamma-aminobutyric acid (GABA) in the brain. This agent's antitumor and antiangiogenesis activities may be related to the inhibition of histone deacetylases and nitric oxide synthase, which results in the inhibition of nitric oxide synthesis. (NCI04)
C29537	Variconazole	Retired_Concepts	Variconazole
C29538	Vaseline	Drug_Vehicle	Vaseline
C29539	Enalapril_Maleate-Hydrochlorothiazide	Antihypertensive_Preparation	Enalapril Maleate/Hydrochlorothiazide|Vaseretic
C29540	Venlafaxine_Hydrochloride	Venlafaxine	Venlafaxine Hydrochloride|Effexor|VENLAFAXINE HYDROCHLORIDE|Venlafaxine HCl	A synthetic ethyl-cyclohexanol derivative used for the treatment of depression, Venlafaxine Hydrochloride is metabolized to O-desmethylvenlafaxine, which potentiates CNS activity.  Both venlafaxine and its active metabolite inhibit neuronal reuptake of norepinephrine, dopamine, and serotonin. (NCI04)
C29541	Vicodin	Retired_Concepts	Vicodin
C29542	Etoposide_Prednisone_Vinblastine	Chemotherapy_Regimen	Etoposide/Prednisone/Vinblastine|Vinblastine/Etoposide/Pred
C29544	Vortex_Mixer	Diagnostic_Therapeutic_and_Research_Equipment	Vortex Mixer|Vortexer	An electrical rotator that blends or mixes substances or ingredients, in whirling or rotary motion, for homogenizing samples.
C29545	Warburg_Therapy	Pharmacological_Biological_and_Instrumental_Interventions	Warburg Therapy|Oxygen Therapy
C29547	White_Petrolatum-Minerals	Topical_Preparation	White Petrolatum/Minerals	White Petrolatum/Minerals is a compounded agent containing various minerals and white petrolatum, a colloid of semisolid hydrocarbons from petroleum. Approved as a skin protectant, it has topical therapeutic applications since it prevents moisture loss and forms a protective barrier on the skin. White Petrolatum provides an optimal vehicle for delivering many therapeutic ingredients.  It is also used in food, plastic and other industries. (NCI04)
C29548	Wild_Type_and_Mutant_MGMT_Vector	Gene-Vector_Complex	Wild Type and Mutant MGMT Vector	Wild Type and Mutant MGMT Vectors are genetic carrier vehicles containing an in vivo selection marker derived from natural or mutant O-6 methylguanine-DNA methyltransferase (MGMT) and are used in gene therapy and biomedical research for selection of specific traits in targeted cells, such as genes that confer resistance to chemotherapeutic agents. Mutant MGMTs resistant to the MGMT inactivator O-6-benzylguanine (BG) are potent markers for in vivo selection in irradiated and non-myelo ablated mouse models using BG plus alkylating agents to drive selection. (NCI04)
C29549	Zolimomab_Aritox	Ricin_Immunoconjugate	Zolimomab Aritox|Anti-CD5 MoAb|Anti-CD5 T-Lymphocyte Immunotoxin|Anti-T-Cell RTA Immunotoxin|Anti-T-Cell Ricin A Chain Immunotoxin|CD5-Immunoconjugate|H65-RTA|Orthozyme-CD5 Plus|Xomazyme CD5 Plus	An immunotoxin consisting of a murine anti-CD5 monoclonal antibody conjugated to the ricin A chain.  The anti-CD5 monoclonal antibody component binds to CD5, a T-cell associated antigen, thereby targeting the delivery of the cytotoxic ricin A chain to T-cells.  The ricin A chain component binds to T-cells and disrupts ribosomal activity and protein synthesis and induces cell cycle arrest. (NCI04)
C29551	Zaleplon	Sedative_and_Hypnotic	Zaleplon|Sonata|ZALEPLON
C29552	Zinc_Undecylenate	Antifungal_Agent	Zinc Undecylenate	A natural or synthetic fungistatic fatty acid, antifungal Zinc Undecylenate is used topically in creams against fungal infections, eczemas, ringworm, and other cutaneous conditions. The zinc provides an astringent action, reducing rawness and irritation. (NCI04)
C29553	Zolpidem_Tartrate	Sedative_and_Hypnotic	Zolpidem Tartrate|Ambien|ZOLPIDEM TARTRATE	The tartrate salt of a non-benzodiazepine of the imidazopyridine class with sedative-hypnotic activity. Zolpidem binds to the omega-1 subclass of the gamma-aminobutyric acid type A (GABA-A ) receptor-chloride ionophore complex, thereby opening the chloride channel and resulting in hyperpolarization and inhibition of neuronal firing. (NCI05)
C29554	gp-120_Antigen	Vaccine_Antigen	gp-120 Antigen|gp-120	A recombinant HIV gp120 envelope protein with potential use in HIV vaccine therapy. Gp-120 antigen is used to elicit a gp120-specific T-cell response. (NCI04)
C29555	gp100_Protein_184V	Vaccine_Antigen	gp100 Protein (184V)	A recombinant peptide derived from the gp100 melanoma- antigen with potential use in cancer immunotherapy.  Gp100 human antigen is a self-antigen expressed by melanocytes, pigmented retinal cells and most melanomas. Vaccination with this protein may evoke anti-tumor T cell-mediated cytotoxicity. (NCI04)
C29556	gp100_Peptide-sensitized_Autologous_T-cells_CD4_plus_and_CD8_plus	Biological_Agent	gp100 Peptide-sensitized Autologous T-cells (CD4+ and CD8+)	A population of CD4+ and CD8+ T-cells isolated from a cancer patient that have been sensitized in vitro to the melanoma-associated antigen gp100.  Infusion of gp100 peptide-sensitized autologous T-cells into the cancer patient may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against gp100-positive tumor cells, thereby decreasing tumor growth. (NCI04)
C29557	rCD4_IgG	Retired_Concepts	rCD4/IgG
C29558	rF-MUC-1_DF3-TRICOM	Fowlpox_Virus_Vaccine	rF-MUC-1(DF3)/TRICOM	A synthetic cancer vaccine containing the tumor-associated antigen (TAA) mucin-1 (MUC-1), a protein/antigen found in pancreatic tumor cells.  TRICOM stands for a TRIad of co-stimulatory molecules and is designed to enhance antigen presentation and activation of immune responses critical for tumor destruction.  TRICOM vaccines can introduce three co-stimulatory molecules into cells, thereby activating CD4 and CD8 T-cell populations to levels greater than those achieved with the use of only one-two co-stimulatory molecules.  Dendritic cells infected with TRICOM vectors greatly enhance naive T-cell activation and peptide-specific T-cell stimulation. (NCI04)
C29559	rF-PSA_PSMA_TRICOM	Fowlpox_Virus_Vaccine	rF-PSA/PSMA/TRICOM	A synthetic cancer vaccine containing the tumor-associated antigens prostate specific antigen (PSA) and prostate specific membrane antigen (PSMA), proteins found in prostate tumor cells.  TRICOM stands for a TRIad of co-stimulatory molecules and is designed to enhance antigen presentation and activation of immune responses critical for tumor destruction.  Dendritic cells infected with TRICOM vectors greatly enhance naive T-cell activation, and peptide-specific T-cell stimulation, effects desired in cancer immunotherapy. (NCI04)
C29560	rFowlpox-PSA_L155_TRICOM	Fowlpox_Virus_Vaccine	rFOWLPOX-PSA(L155)-TRICOM Vaccine|PROSTVAC-F|rFOWLPOX-PSA(L155)-TRICOM (PROSTVAC-F/TRICOM)	A synthetic pox-based cancer vaccine containing a tumor-associated antigen derived from prostate specific antigen (PSA), a protein found in prostate tumor cells.  Fowlpox virus is an attractive vector because its genome is easy to manipulate and it does not multiply in human tissues.  TRICOM stands for a TRIad of co-stimulatory molecules and is designed to enhance antigen presentation and activation of immune responses critical for tumor destruction.  Pox vectors can introduce multiple co-stimulatory molecules into cells, thereby activating CD4 and CD8 T-cell populations to levels greater than those achieved with the use of only one-two co-stimulatory molecules.  Dendritic cells infected with TRICOM vectors greatly enhance naive T-cell activation and peptide-specific T-cell stimulation. (NCI04)
C29561	rMVA-PSA_PSMA_TRICOM	Vaccinia_Vaccine	rMVA-PSA/PSMA/TRICOM
C29562	Recombinant_Vaccinia-MUC1-B7_1	Retired_Concepts	Recombinant Vaccinia-MUC1-B7.1|rV-MUC1-B7.1
C29563	Recombinant_Vaccinia-PSA_PSMA	Viral_Vector-Gene_Complex	Recombinant Vaccinia-PSA/PSMA|PSA-PSM-Vaccinia|rV-PSA/PSMA	A recombinant vaccinia virus encoding prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSM) with potential use in cancer immunotherapy. (NCI04)
C29564	Recombinant_Vaccinia-TRP1	Viral_Vector-Gene_Complex	Recombinant Vaccinia-TRP1|Tyrosinase-Related Protein-1-Vaccinia|rV-TRP1	A recombinant vaccinia virus encoding the melanocyte differentiation antigen tyrosinase-related protein-1 (TRP-1) with potential use in cancer immunotherapy. (NCI04)
C29565	rVaccinia-PSA_L155_TRICOM	Vaccinia_Vaccine	rVaccinia-PSA(L155)-TRICOM Vaccine|rVACCINIA-PSA(L155)-TRICOM (PROSTVAC-V/TRICOM)	A recombinant vaccinia virus encoding a modified peptide of the prostate-specific antigen, PSA (L155), and TRICOM with potential use in cancer immunotherapy. TRICOM is comprised of three co-stimulatory molecule transgenes (B7-1, ICAM-1 and LFA-3) that may enhance antigen presentation and activate cytotoxic T-cells against PSA-expressing tumor cells. (NCI04)
C29566	Recombinant_Vaccinia-gp100p209	Viral_Vector-Gene_Complex	Recombinant Vaccinia-gp100:209-217|rv-gp100P209	A recombinant vaccinia virus encoding a modified peptide of the gp100 melanoma-melanocyte antigen with potential use in cancer immunotherapy.  gp100 human antigen is a wild type self-antigen expressed by melanocytes, pigmented retinal cells and most melanomas. gp100p209 is a fragment epitope of gp100 in which the threonine in position 2 is replaced with methionine; this modification may stimulate tumor infiltrating lymphocytes (TIL) more efficiently. (NCI04)
C29567	y2B8	Retired_Concepts	y2B8
C29568	Dual_Specificity_Phosphatase-1	Dual-Specificity_Phosphoprotein_Phosphatase	Dual Specificity Phosphatase 1|DUSP1|Dual Specificity Protein Phosphatase 1|Dual Specificity Protein Phosphatase hVH1|Dual-Specificity Phosphatase 1|EC 3.1.3.16|EC 3.1.3.48|MAP Kinase Phosphatase 1|MAP Kinase Phosphatase-1|MKP-1|Protein-Tyrosine Phosphatase CL100|Protein-Tyrosine Phosphatase, Nonreceptor-Type, 10|Serine/Threonine Specific Protein Phosphatase	Dual Specificity Phosphatase 1, encoded by the DUSP1 gene, is induced by oxidative stress and heat shock. This protein specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. (from LocusLink and Swiss-Prot)
C29569	Presynaptic_Protein-SAP97	Regulatory_Protein	Presynaptic Protein SAP97|Discs Large (Drosophila) Homolog 1|Discs Large Homolog 1|Synapse-Associated Protein 97|hDlg	Encoded by human DLG1 Gene (MAGUK Family), alternative isoforms 1 (904-aa) and 2 (926-aa) of 100-kD Presynaptic Protein SAP97 are a putative kinase that appears to regulate protein targeting and contains one SH3, one Guanylate Kinase-like, and three PDZ/DHR domains. DLG1 binds to membrane cytoskeletal protein 4.1 (EPB41) and to KIF13B, and interacts with the KCNAB1 channel as well as the cytoplasmic tail of NMDA receptor subunits. LCK interacts with the proline-rich N-terminal domain of DLG1. Interacting with actin-binding ezrin, SAP97 is also involved in cell shape morphogenesis. (NCI)
C29570	Presynaptic_Density_Protein-95	Regulatory_Protein	Presynaptic Density Protein 95|Discs Large (Drosophila) Homolog 4|Discs Large Homolog 4|PSD-95|Postsynaptic Density-95|Synapse-Associated Protein 90	Widely expressed by human DLG4 Gene (MAGUK Family), 767-aa 85-kD cytoplasmic Presynaptic Density Protein 95 (concentrated at presynaptic junctions), contains one SH3, one Guanylate Kinase-like, and three PDZ/DHR domains. It heteromultimerizes with DLG2, interacts with the cytoplasmic tail of NMDA receptor subunits, and, with DLG2, mediates NMDA and potassium channel clustering. PSD-95 also binds to KIF13B and interacts through a PDZ domain with NLGN1. DLG4 may form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins. (NCI)
C29571	TATA-Binding_Protein-Associated_Phosphoprotein	Transcription_Repressor_Corepressor	TATA-Binding Protein-Associated Phosphoprotein|DR1 Protein|Down-Regulator of Transcription 1|Downregulator of Transcription 1 TBP-Binding DR1|NC2-Beta|Negative Cofactor 2-Beta|TATA Box-Binding Protein-Associated Phosphoprotein DR1	Encoded by human DR1 Gene, TATA-Binding Protein-Associated Phosphoprotein represses both basal and activated levels of transcription. DR1 phosphorylation affects its interaction with TBP. The DR1 protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region and represses transcription with DRAP1 by inhibiting pre-initiation complex formation through interaction with TFIID and DNA. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. (NCI)
C29572	DR1-Associated_Protein-1	Transcription_Repressor_Corepressor	DR1-Associated Protein 1|DR1-Associated Corepressor|NC2-Alpha|Negative Cofactor 2 Alpha	Encoded by human DRAP1 Gene, DR1-Associated Protein 1 is a corepressor of transcription that interacts with DR1 to enhance DR1-mediated repression. DR1 interacts with the TATA-binding protein (TBP) of TFIID and prevents formation of an active transcription complex by precluding TFIIA and/or TFIIB entry into the preinitiation complex. DRAP1 and DR1 interaction is required for corepressor function and stabilizes the TBP-DR1-DNA complex. DRAP1 protein contains a histone fold motif at the N terminus and a proline-rich region at the C terminus. The binding of DRAP1 to DR1 is dependent on the histone fold motif present in each protein. DRAP1 expression facilitates the maintenance of a differentiated state by silencing specific genes. (NCI)
C29573	HLA_Class-II_Histocompatibility_Antigen-DRB	HLA-DR_Antigen	HLA Class II Histocompatibility Antigen DRB	HLA class II DR beta chain proteins (26-28 kD) form heterodimers with alpha (DRA) chains, both anchored in the membrane. Expressed in antigen presenting cells (B lymphocytes, dendritic cells, macrophages), alpha/beta heterodimers present peptides derived from extracellular proteins. Hundreds of DRB alleles have been described and typing for these polymorphisms is done for transplantation. (NCI)
C29574	Nitric_Oxide_Synthetase_Inhibitor	Enzyme_Inhibitor	Nitric Oxide Synthetase Inhibitor	A class of agents that inhibit nitric oxide synthetases (NOSs), enzymes which catalyze the production of nitric oxide (NO).  The three known NOS isoforms (neuronal, endothelial and inducible) are all dimeric, bi-domain enzymes that contain iron protoporphyrin IX, flavin adenine dinucleotide, mononucleotide, and tetrahydrobiopterin as bound prosthetic groups. (NCI04)
C29575	DNA_Polymerase_Inhibitor	Enzyme_Inhibitor	DNA Polymerase Inhibitor	An agent that inhibits the function of DNA polymerase, an enzyme that is essential for DNA replication and repair, and subsequently for cell division.  By inhibiting DNA polymerase, a DNA polymerase inhibitor induces cell death, especially in the rapidly proliferating cell populations found in tumors. (NCI04)
C29576	Beta-Adrenergic_Blocking_Agent	Adrenergic_Agent|Antihypertensive_Agent	Beta-Adrenergic Antagonist|Beta-Adrenergic Blocking Agent|Beta-Blocker	Natural or synthetic Beta Adrenergic Blocking Agents typically bind to - but do not activate - beta-adrenergic receptors, blocking or diminishing physiologic beta-adrenergic agonist actions and activation of the sympathetic system. Reducing cardiac output, beta adrenergic antagonists are generally used for treatment of hypertension, cardiac arrythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. (NCI04)
C29577	Carbonic_Anhydrase_Inhibitor	Enzyme_Inhibitor	Carbonic Anhydrase Inhibitor	An agent that inhibits the function of carbonic anhydrase, a zinc-containing enzyme that catalyzes the rapid conversion of carbon dioxide and water into carbonic acid, protons and bicarbonate ions.  Distributed throughout many cells and tissues, carbonic anhydrases play important roles in mineral and metabolic homeostasis. (NCI04)
C29578	Histamine-1_Receptor_Antagonist	Antihistamine	Histamine-1 Receptor Antagonist|H-1 Receptor Antagonist
C29579	Thrombospondin_Type-I_Domain-2_Protein	Protein_with_Unknown_or_Unclassified_Function	Thrombospondin Type I Domain 2 Protein|THSD2	Encoded by human THSD2 Gene, Thrombospondin Type I Domain 2 Protein contains a furin-like cysteine-rich region and is similar to thrombospondin type 1 domain-containing proteins. Furin-like domains have been found in proteins involved in signal transduction by receptor tyrosine kinases. The function of this protein has not been determined. (NCI)
C29580	Hypothetical_Protein-FLJ20174	Protein_with_Unknown_or_Unclassified_Function	SID1 Transmembrane Family, Member 1|Hypothetical Protein FLJ20174|SID1|SIDT1	Encoded by human FLJ20174 Gene, Hypothetical Protein FLJ20174 is a potential homolog of sid-1 (C. elegans), a predicted transmembrane protein localized to the cell periphery, and required cell autonomously for systemic RNA interference (RNAi). (NCI)
C29581	Leucine-Rich_Repeat_Transmembrane_Protein_FLRT3	Protein_with_Unknown_or_Unclassified_Function	Leucine-Rich Repeat Transmembrane Protein FLRT3|Fibronectin Leucine Rich Transmembrane Protein 3|Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 3	Expressed in kidney, brain, pancreas, skeletal muscle, lung, liver, placenta, and heart by human FLRT3 Gene (FLRT Family), 649-aa 73-kDa (precursor) Leucine-Rich Repeat Transmembrane Protein FLRT3 is a probable type I membrane protein containing a fibronectin type III domain and 10 leucine-rich repeats that may have a function in cell adhesion and/or receptor signaling. FLRT3 resembles small leucine-rich proteoglycans found in the extracellular matrix and shares 55% amino acid sequence identity with FLRT1 and 44% identity with FLRT2. (NCI)
C29582	FGFR1_Oncogene_Partner	Protein_with_Unknown_or_Unclassified_Function	FGFR1 Oncogene Partner|FOP|Fibroblast Growth Factor Receptor 1 Oncogene Partner	Encoded by human FGFR1OP Gene, ubiquitous 399-aa 43-kDa hydrophilic FGFR1 Oncogene Partner protein contains N- and C-terminal alpha helices harboring leucine-rich repeats. FOP may play a role in erythroid cell proliferation and differentiation. (NCI)
C29583	Epithelial_Mesenchymal_Transition_Tumor_of_the_Mouse_Mammary_Gland	Malignant_Neoplasms_of_the_Mouse_Mammary_Gland	Epithelial Mesenchymal Transition Tumor of the Mouse Mammary Gland|EMT|Epithelial Mesenchymal Transition Tumor	A tumor composed of a prominent spindle cell population with or without an atypical epithelial component. These tumors are identified by immunohistochemical staining for cytokeratin, smooth muscle actin and vimentin. EMT tumors are more frequent in some GEM models than others (ILK1 and GSK3), frequently do not express the transgenic oncogene and are associated with up regulation of snail or slug. These tumors have been classified in the past as fibrosarcomas, carcinosarcomas, or metaplastic carcinomas. However, they deserve a distinctive taxonomic category.
C29584	FGF_Receptor_Activating_Protein-1	Protein_with_Unknown_or_Unclassified_Function	FGF Receptor Activating Protein 1|FRAG1	Encoded by human FRAG1 Gene, FGF Receptor Activating Protein 1 appears to be a 315-aa 36-kDa membrane-spanning protein whose function is not currently known. FRAG1 resides in a chromosome region implicated in Beckwith-Wiedemann syndrome and frequent loss of heterozygosity in multiple tumor types. (from Proc Natl Acad Sci 1996;93:8956-61 and Genomics 1999;62:59-66)
C29585	Proto-Oncogene-FRAT1_Protein	Protein_with_Unknown_or_Unclassified_Function	Proto-Oncogene FRAT1 Protein|FRAT1|Frequently Rearranged in Advanced T-Cell Lymphomas Protein	Encoded as same the isoform by two alternative transcripts of human FRAT1 Gene (GSK-3-Binding Protein Family), 279-aa 29-kDa Proto-Oncogene FRAT1 Protein is 79% identical to mouse Frat1, contains 3 conserved regions, and appears to participate in the WNT signaling pathway. FRAT1 binds DVL1. FRAT1 may bind GSK-3, preventing GSK-3-dependent phosphorylations and may inhibit beta-catenin phosphorylation, preventing its degradation by the ubiquitin-proteasome pathway. GBP, FRAT1, and FRAT2 contain similar sequences. GSK3-binding and -inhibitory activities of FRAT2 reside in the conserved C-terminal domain III. FRAT1 may play a role in tumor progression and lymphomagenesis with PIM1 and MYC. (NCI)
C29586	FYN-Related_Kinase	SRC_Family_Tyrosine_Kinase	FYN-Related Kinase|GTK|GTK Homolog|Nuclear Tyrosine Protein Kinase RAK|RAK|Tyrosine-Protein Kinase FRK	Encoded by human FRK Gene (SRC Family), 505-aa 58-kDa FYN-Related Kinase (tyrosine kinase) contains a putative ATP-binding motif, tyrosine kinase motifs, and SH2 and SH3 domains. FRK lacks a myristylation signal, has autophosphorylation activity, is C-terminal tyrosine phosphorylated by CSK, and may function during G1/S and suppress growth. (NCI)
C29587	FGFR_Signalling_Adaptor	Adaptor_Signaling_Protein	FGFR Substrate 2|FGFR Signaling Adaptor|FRS2|FRS2-Alpha|FRS2A|Fibroblast Growth Factor Receptor Substrate 2|SUC1-Associated Neurotrophic Factor Target	Encoded by human FRS2 Gene, 508-aa 56.8-kD FGFR Substrate 2 contains a myristylation sequence, a PTB domain, and 4 potential GRB2/SHP2-binding sites. FGFR-mediated Tyr-phosphorylated FRS2 binds to FGFR1 and GRB2/SOS in response to FGF or NGF. An FGFR1 juxtamembrane segment and the PTB domain appear to interact and mediate FRS Tyr phosphorylation. Myristylation is essential for FRS2 membrane localization, Tyr phosphorylation, GRB2/SOS recruitment, and MAPK activation. FRS2A is Thr phosphorylated by MAPK in response to FGF, insulin, EGF, and PDGF. FRS2 may function as a lipid-anchored docking protein that targets signaling molecules to the plasma membrane in response to FGF to link receptor activation with MAPK and other pathways essential for cell growth and differentiation. (NCI)
C29588	FGFR_Substrate-3	Adaptor_Signaling_Protein	FGFR Substrate 3|FRS2-Beta|FRS2B|FRS3|Fibroblast Growth Factor Receptor Substrate 3|SNT2|SUC1-Associated Neurotrophic Factor Target 2	Encoded by human FRS3 Gene, 492-aa 54-kDa plasma membrane-associated FGFR Substrate 3 is an FGFR substrate that links FGFR stimulation to RAS activators. Similar (49% identical) to FRS2, FRS3 also contains a myristylation sequence, a PTB domain, and Tyr-containing motifs that govern GRB2 and SHP2 recruitment. FRS2 and FRS3 bind directly to FGFR1; an FGFR1 juxtamembrane segment and the PTB domain appear to interact and mediate FRS Tyr phosphorylation. (NCI)
C29589	Phenylalanyl-tRNA_Synthetase_Beta-Subunit	Protein_with_Unknown_or_Unclassified_Function	Phenylalanyl-tRNA Synthetase Beta-Subunit|FARSLB|FRSB|HSPC173|PheRS|Phenylalanine-tRNA Ligase Beta Chain|Phenylalanyl-tRNA Synthetase Beta Chain	Human FRSB Gene at 2q36.1 encodes the non-catalytic beta subunit of heterodimeric (alpha/beta) 2 Phenylalanyl-tRNA Synthetase. The two subunits are coordinately overexpressed in an acute-phase chronic myeloid leukemia cell line. (Biochem Biophys Res Commun 1999;255:765-73)
C29590	FUS-1_Protein	Protein_with_Unknown_or_Unclassified_Function	FUS-1 Protein|Fusion 1 Protein|PDGFA associated protein 2	Expressed in heart, lung, skeletal muscle, kidney, pancreas, brain, liver, and placenta by human PDAP2 Gene (FUS1 Family), FUS-1 Protein may cause G1 arrest and induce apoptosis. (NCI)
C29591	Follicular_Variant_Translocation_Protein-1	Protein_with_Unknown_or_Unclassified_Function	Follicular Variant Translocation Protein 1|FVT1	Expressed in hematopoietic tissues and PHA-stimulated lymphocytes by human FVT1 Gene (SDR Family), the function of 332-aa 36-kDa (precursor) secreted Follicular Variant Translocation Protein 1 is unknown. (NCI)
C29592	EPS8-Related_Protein-1	Protein_with_Unknown_or_Unclassified_Function	Epidermal Growth Factor Receptor Pathway Substrate 8-Like Protein 1|EPS8-Like 1|EPS8-Related Protein 1|EPS8L1|Epidermal Growth Factor Receptor Pathway Substrate 8 Related Protein 1|Epidermal Growth Factor Receptor Pathway Substrate 8-Related Protein 1	Epidermal Growth Factor Receptor Pathway Substrate 8-Like Protein 1, encoded by the EPS8L1 gene, is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Several alternatively spliced transcript variants encoding different isoforms exist. (LocusLink)
C29593	EPS8-Related_Protein-2	Protein_with_Unknown_or_Unclassified_Function	Epidermal Growth Factor Receptor Pathway Substrate 8-Like Protein 2|EPS8-Related Protein 2|EPS8L2|Epidermal Growth Factor Receptor Pathway Substrate 8-Related Protein 2|Hypothetical Protein FLJ22171	Encoded by human EPS8L2 Gene, EPS8-Related Protein 2 is a protein of unknown function related to EGFR Pathway Substrate 8 (EPS8), a substrate for the EGFR. (NCI)
C29594	Growth-Arrest-Specific_Protein-2	Regulatory_Protein	Growth-Arrest-Specific Protein 2|GAS-2	Widely expressed at growth arrest by human GAS2 Gene, 36-kD Growth-Arrest-Specific Protein 2 is a component of the microfilament system. Localized at the actin cytoskeleton, along stress fibers, and at the plasma membrane, GS2 is phosphorylated on serine residues during G0/G1 transition. Hyperphosphorylated GAS2 accumulates at membrane ruffles. In apoptosis, GAS2 is a substrate for caspases; cleaved forms of GAS2 induce actin cytoskeletal rearrangements and cell shape changes. (NCI)
C29595	Essential_Amino_Acid	Amino_Acid|Nutritional_Supplement	Essential Amino Acid	Refer to those amino acids that can not be synthesized in the body and can only be obtained through food supply.(NCI)
C29596	Non-Essential_Amino_Acid	Amino_Acid	Non-Essential Amino Acid	Refer to those amino acids that your body can create out of other chemicals found in your body.(NCI)
C29597	Histidine	Essential_Amino_Acid	Histidine|l-Histidine	A semi-essential amino acid (children should obtain it from food) needed in humans for growth and tissue repair, Histidine is important for maintenance of myelin sheaths that protect nerve cells and is metabolized to the neurotransmitter histamine. Histamines play many roles in immunity, gastric secretion, and sexual functions. Histidine is also required for blood cell manufacture and protects tissues against damage caused by radiation and heavy metals. (NCI04)
C29598	Isoleucine	Essential_Amino_Acid	Isoleucine	One of nine essential amino acids in humans (present in dietary proteins), Isoleucine has diverse physiological functions, such as assisting wound healing, detoxification of nitrogenous wastes, stimulating immune function, and promoting secretion of several hormones. Necessary for hemoglobin formation and regulating blood sugar and energy levels, isoleucine is concentrated in muscle tissues in humans. Isoleucine is found especially in meats, fish, cheese, eggs, and most seeds and nuts. (NCI04)
C29599	Leucine	Essential_Amino_Acid	Leucine	One of nine essential amino acids in humans (provided by food), Leucine is important for protein synthesis and many metabolic functions. Leucine contributes to regulation of blood-sugar levels; growth and repair of muscle and bone tissue; growth hormone production; and wound healing. Leucine also prevents breakdown of muscle proteins after trauma or severe stress and may be beneficial for individuals with phenylketonuria. Leucine is available in many foods and deficiency is rare. (NCI04)
C29600	Methionine	Essential_Amino_Acid	Methionine|L-Methionine	One of nine essential amino acids in humans (provided by food), Methionine is required for growth and tissue repair. A sulphur-containing amino acid, methionine improves the tone and pliability of skin, hair, and strengthens nails. Involved in many detoxifying processes, sulphur provided by methionine protects cells from pollutants, slows cell aging, and is essential for absorption and bio-availability of selenium and zinc. Methionine chelates heavy metals, such as lead and mercury, aiding their excretion. It also acts as a lipotropic agent and prevents excess fat buildup in the liver. (NCI04)
C29601	Phenylalanine	Essential_Amino_Acid	Phenylalanine	An essential aromatic amino acid in humans (provided by food), Phenylalanine plays a key role in the biosynthesis of other amino acids and is important in the structure and function of many proteins and enzymes. Phenylalanine is converted to tyrosine, used in the biosynthesis of dopamine and norepinephrine neurotransmitters. The L-form of Phenylalanine is incorporated into proteins, while the D-form acts as a painkiller. Absorption of ultraviolet radiation by Phenylalanine is used to quantify protein amounts. (NCI04)
C29602	Threonine	Essential_Amino_Acid	Threonine	An essential amino acid in humans (provided by food), Threonine is an important residue of many proteins, such as tooth enamel, collagen, and elastin. An important amino acid for the nervous system, threonine also plays an important role in porphyrin and fat metabolism and prevents fat buildup in the liver. Useful with intestinal disorders and indigestion, threonine has also been used to alleviate anxiety and mild depression. (NCI04)
C29603	Tryptophan	Essential_Amino_Acid	Tryptophan	The least plentiful of all 22 amino acids and an essential amino acid in humans (provided by food), Tryptophan is found in most proteins and a precursor of serotonin. Tryptophan is converted to 5-hydroxy-tryptophan (5-HTP), converted in turn to serotonin, a neurotransmitter essential in regulating appetite, sleep, mood, and pain. Tryptophan is a natural sedative and present in dairy products, meats, brown rice, fish, and soybeans. (NCI04)
C29604	Valine	Essential_Amino_Acid	Valine	An aliphatic and extremely hydrophobic essential amino acid in humans related to leucine, Valine is found in many proteins, mostly in the interior of globular proteins helping to determine three-dimensional structure. A glycogenic amino acid, valine maintains mental vigor, muscle coordination, and emotional calm. Valine is obtained from soy, cheese, fish, meats and vegetables. Valine supplements are used for muscle growth, tissue repair, and energy. (NCI04)
C29605	Alanine	Non-Essential_Amino_Acid	Alanine	A small non-essential amino acid in humans, Alanine is one of the most widely used for protein construction and is involved in the metabolism of tryptophan and vitamin pyridoxine. Alanine is an important source of energy for muscles and central nervous system, strengthens the immune system, helps in the metabolism of sugars and organic acids, and displays a cholesterol-reducing effect in animals. (NCI04)
C29606	Arginine	Non-Essential_Amino_Acid	Arginine Hydrochloride|ARGININE HYDROCHLORIDE|Arginine|L-Arginine	An essential amino acid in juvenile humans, Arginine is a complex amino acid, often found at active site in proteins and enzymes due to its amine-containing side chain. Arginine may prevent or treat heart and circulatory diseases, combat fatigue, and stimulate the immune system. It also boosts production of nitric oxide, relaxing blood vessels, and treating angina and other cardiovascular problems. Arginine is also an important intermediate in the urea cycle and in detoxification of nitrogenous wastes. (NCI04)
C29607	Asparagine	Non-Essential_Amino_Acid	Asparagine	A non-essential amino acid in humans, Asparagine is a beta-amido derivative of aspartic acid and plays an important role in the biosynthesis of glycoproteins and other proteins. A metabolic precursor to aspartate, Asparagine is a nontoxic carrier of residual ammonia to be eliminated from the body. Asparagine acts as diuretic. (NCI04)
C29608	Aspartic_Acid	Non-Essential_Amino_Acid	Aspartic Acid	A non-essential amino acid in humans, Aspartic Acid has an overall negative charge and plays an important role in the synthesis of other amino acids and in the citric acid and urea cycles. Asparagine, arginine, lysine, methionine, isoleucine, and some nucleotides are synthesized from aspartic acid. Aspartic acid also serves as a neurotransmitter. (NCI04)
C29609	Cysteine	Non-Essential_Amino_Acid	Cysteine	A non-essential sulfur-containing amino acid in humans, related to cystine, Cysteine is important for protein synthesis, detoxification, and diverse metabolic functions. Found in beta-keratin, the main protein in nails, skin, and hair, Cysteine is important in collagen production, as well as skin elasticity and texture. Also required in the manufacture of amino acid taurine, Cysteine is a component of the antioxidant glutathione, and plays a role in the metabolism of essential biochemicals such as coenzyme A, heparin, and biotin. (NCI04)
C29610	Cystine	Non-Essential_Amino_Acid	Cystine|L-Cystine	Not considered one of the 20 amino acids, Cystine is a sulfur-containing derivative obtained from oxidation of cysteine amino acid thiol side chains.  It functions as an antioxidant and protects tissues against radiation and pollution, slowing the aging process.  It also aids protein synthesis. Cystine is abundant in many proteins of skeletal tissues and skin, and found in insulin and digestive enzymes chromotrypsinogen A, papain, and trypsinogen. (NCI04)
C29611	Ornithine	Non-Essential_Amino_Acid	Ornithine
C29612	Proline	Non-Essential_Amino_Acid	Proline	A cyclic, nonessential amino acid (actually, an imino acid) in humans (synthesized from glutamic acid and other amino acids), Proline is a constituent of many proteins. Found in high concentrations in collagen, proline constitutes almost a third of the residues. Collagen is the main supportive protein of skin, tendons, bones, and connective tissue and promotes their health and heeling. (NCI04)
C29613	Serine	Non-Essential_Amino_Acid	Serine|2-Amino-3-hydroxypropionic Acid|beta-Hydroxyalanine|l-Serine	A non-essential amino acid in humans (synthesized by the body), Serine is present and functionally important in many proteins. With an alcohol group, serine is needed for the metabolism of fats, fatty acids, and cell membranes; muscle growth; and a healthy immune system. It also plays a major role in pyrimidine, purine, creatine, and porphyrin biosynthetic pathways. Serine is also found at the active site of the serine protease enzyme class that includes trypsin and chymotrypsin. (NCI04)
C29614	EPS8-Related_Protein-3	Protein_with_Unknown_or_Unclassified_Function	Epidermal Growth Factor Receptor Pathway Substrate 8-Like Protein 3|EPS8-Like 3|EPS8-Related Protein 3|EPS8L3|Epidermal Growth Factor Receptor Pathway Substrate 8 Related Protein 3|Epidermal Growth Factor Receptor Pathway Substrate 8-Related Protein 3	Epidermal Growth Factor Receptor Pathway Substrate 8-Like Protein 3, encoded by the EPS8L3 gene, is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. (LocusLink)
C29615	Fatty_Acid-Binding_Protein-1	Ligand_Binding_Protein	Fatty Acid-Binding Protein 1|FABP1|Fatty Acid Binding Protein 1, Liver|Fatty Acid-Binding Protein, Liver|L-FABP|Z Protein	Fatty Acid-Binding Protein 1, encoded by the FABP1 gene, is the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein binds free fatty acids and their coenzyme a derivatives, bilirubin, and some other small molecules in the cytoplasm. It may be involved in intracellular lipid transport. (from LocusLink and Swiss-Prot)
C29616	Fatty_Acid-Binding_Protein-2	Ligand_Binding_Protein	Fatty Acid-Binding Protein 2|FABP2|FABPI|Fatty Acid Binding Protein 2, Intestinal|Fatty Acid-Binding Protein, Intestinal|I-FABP	Fatty Acid-Binding Protein 2, encoded by the FABP2 gene, belongs to the fatty-acid binding protein (FABP) family thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. Intestinal fatty acid-binding protein 2 gene contains four exons and is an abundant cytosolic protein in small intestine epithelial cells. The FABP2 gene has a polymorphism in position 54, which changes Ala-54 (71% of the population) to Thr-54 (29%). The Thr-54 allele has a 2-fold greater affinity for long-chain fatty acids than the Ala-54 allele. Thr-54 is associated with increased fat oxidation and insulin resistance. (from LocusLink and Swiss-Prot)
C29617	Fatty_Acid-Binding_Protein-4	Ligand_Binding_Protein	Fatty Acid-Binding Protein 4|FABP4	Fatty Acid-Binding Protein 4, encoded by the FABP4 gene, is a fatty acid binding protein found in adipocytes. This protein binds both long chain fatty acid and retinoic acid and is involved in lipid transport protein in adipocytes. (from LocusLink and Swiss-Prot)
C29618	Therapeutic_Androstanolone	Anabolic_Steroid	Therapeutic Androstanolone|DHT|Dihydrotestosterone	A therapeutic anabolic steroid hormone identical to endogenous dihydrotestosterone.  Androstanolone binds to and activates specific nuclear receptors.  This agent may be used for testosterone replacement therapy in hypogonadal men, in HIV-wasting syndrome, and in other conditions in order to increase nitrogen retention and fat-free muscle mass. (NCI04)
C29619	Androstanolone	Androgen	Androstanolone|DHT|Dihydrotestosterone
C29620	Geminin	Cell_Cycle_Protein	Geminin	Encoded by human GMNN Gene (Geminin Family), 209-aa 24-kDa Geminin inhibits DNA replication during S, G2, and M phases by sequestering CDT1, a replication initiation factor necessary for MCM loading, to prevent the incorporation of MCM complex into prereplication complex. Geminin has a destruction box sequence (RRTLKVIQP) and is ubiquitinated by the anaphase-promoting complex. Geminin destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Geminin may also inhibit inappropriate origin firing by targeting CDT1. In the normal cell cycle, CDT1 is present only in G1 and S phases, whereas geminin is present in S and G2 phases. (NCI)
C29621	Glycoprotein-A33	Protein_with_Unknown_or_Unclassified_Function|Transmembrane_Protein	Glycoprotein A33|Cell Surface A33 Antigen	Expressed in gastrointestinal epithelium by human GPA33 Gene, 319-aa 35.6-kDa (precursor) Glycoprotein A33 is a palmitoylated N-glycosylated type I transmembrane cell surface antigen with a 213-amino acid extracellular region (containing a Ig-like V domain and a Ig-like C2 domain), a transmembrane domain, and a 62-amino acid intracellular tail. GPA33 may function as a cell surface receptor or play a role in cell adhesion. (NCI)
C29627	Metaplasia_of_the_Mouse_Prostate_Gland	Other_Non-Neoplastic_Proliferation_of_the_Mouse_Prostate_Gland	Metaplasia of the Mouse Prostate Gland|Metaplasia of the Prostate Gland
C29628	Well_Differentiated_Invasive_Adenocarcinoma_of_the_Mouse_Prostate_Gland	Invasive_Adenocarcinoma_of_the_Mouse_Prostate_Gland	Well Differentiated Invasive Adenocarcinoma of the Mouse Prostate Gland|Well Differentiated Invasive Adenocarcinoma of the Prostate Gland	Majority of the invasive focus is composed of discreet, well formed glands.
C29629	Combination_Medication	Adjuvant	Combination Medication	A medication containing two or more active ingredients acting in a synergistic or potentiating manner to treat a disease state.(NCI)
C29630	Cough_and_Cold_Preparation	Combination_Medication	Cough and Cold Preparation
C29631	Analgesic_Preparation	Combination_Medication	Analgesic Preparation	Natural or synthetic compound mixtures, Analgesic Preparations relieve pain by altering the perception of nociceptive stimuli without loss of consciousness. Analgesic compounds may act at opioid receptors (morphine-like drugs) or at other central or peripheral sites (non-steroidal anti-inflammatory agents). (NCI04)
C29632	Laxative_Preparation	Combination_Medication	Laxative Preparation
C29633	Antacid_Preparation	Combination_Medication	Antacid Preparation	Natural or synthetic compounds or mixtures, Antiacid Preparations such as sodium bicarbonate, sodium citrate, and phosphate salts act as proton acceptors, neutralizing the acidity of a biologic environment (skin, gastric content, urine, etc.) and raising the pH. These agents are used topically or systemically for management of metabolic acidosis, improved muscle contraction, and hyper-acidic conditions (preventing, counteracting, or neutralizing stomach acidity). (NCI04)
C29634	Antirheumatic_Preparation	Combination_Medication	Antirheumatic Preparation	Used systemically or topically, natural or synthetic Antirheumatic Preparations relieve and control the symptoms of rheumatic diseases (rheumatoid arthritis) by reducing inflammation and pain, or reinstating mobility and function of articulations. Nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and immunosuppressive cytotoxics are examples of antirheumatic agents. (NCI04)
C29635	Asthma_Preparation	Combination_Medication	Asthma Preparation	Containing natural or synthetic agents, Asthma Preparations relieve asthma (a recurrent airway obstruction) in various ways by reducing bronchial spasm, dyspnea, allergic reaction, local inflammation, and pain. Anti-asthmatic agents can be mainly bronchodilators (beta-adrenoreceptor agonists, xanthines, muscarinic-receptor antagonists) and anti-inflammatory agents (glucocorticoids, cromolyn). Other agents, such as anti-histamines and antibiotics, may be used in asthma preparations. (NCI04)
C29636	Antihypertensive_Preparation	Combination_Medication	Antihypertensive Preparation	Natural or synthetic Antihypertensive Preparations reduce elevated blood pressure through diverse mechanisms: calcium channel (and conductance) blockage, beta- and alpha-adrenergic blockage, angiotensin-converting enzyme inhibition, etc.. Their effects induce diuresis and peripheral vasodilation. (NCI04)
C29637	Anti-infective_Preparation	Combination_Medication	Anti-infective Preparation	For internal or topical application, Anti-infective Preparations contain natural or synthetic antibiotic agents that act therapeutically or prophylactically against infectious viral, bacterial, protozoal, or other agents by inhibiting their growth, replication, and survival. Usually, antiinfective preparations are formulated sterile. (NCI04)
C29638	Electrolyte_Replacement_Preparation	Combination_Medication	Electrolyte Replacement Preparation
C29639	Topical_Preparation	Combination_Medication	Topical Preparation
C29640	Oral_Contraceptive_Preparation	Combination_Medication	Oral Contraceptive Preparation
C29641	G_Protein-Coupled_Receptor-39-1	G_Protein-Coupled_Receptor	G Protein-Coupled Receptor 39|GPR39|Putative G Protein-Coupled Receptor GPR39	Widely expressed by human GPR39 Gene (GPCR1 Family), 453-aa 51-kDa 7-transmembrane orphan G Protein-Coupled Receptor 39 exhibits high homology to the growth hormone secretagogue receptor (GHSR). (NCI)
C29642	Sexual_Maturation	Organismal_Process	Sexual Maturation	Becoming physiologically capable of sexual reproduction is marked by genital maturation, development of secondary sex characteristics, and, in girls, the first occurrence of menstruation. (from http://www.onelook.com)
C29643	G_Protein-Coupled_Receptor-54-1	G_Protein-Coupled_Receptor	G Protein-Coupled Receptor 54|G Protein-Coupled Receptor AXOR12|G-Protein-Coupled Receptor GPR54|GPR54|Metastin Receptor	Encoded by human GPR54 Gene, 395-aa 43-kDa G Protein-Coupled Receptor 54 is a Gq/11-coupled receptor for endogenous KISS1 (Metastin), which appears to inhibit chemotaxis. (NCI)
C29644	pH_Homeostasis	Homeostasis	pH Homeostasis	pH homeostasis is one of numerous control systems that are involved in keeping the body's internal milieu consistent within a narrow range of variation and are important to the continuation of life. Important homeostatic mechanisms in the maintenance of blood pH include the buffering action of bicarbonate, and the actions of the renal-respiratory system. (from NCI)
C29645	mRNA_Surveillance	Biochemical_Process	mRNA Surveillance	mRNA Surveillance works within elaborate cellular mechanisms to ensure accurate gene expression by assessing suitable mRNA quality for translation and prevents the synthesis of truncated or aberrant proteins. By nonsense-mediated decay, mRNA surveillance facilitates the detection and destruction of mRNAs that contain premature termination codons. Also, by nonstop decay, mRNA surveillance depletes mRNAs that lack in-frame termination codons.
C29646	RNA_Proof-Reading	mRNA_Surveillance	RNA Proof-Reading	RNA Proof-Reading is the process whereby RNA polymerase can backup and remove incorrect bases during the process of transcription.
C29647	Non-Stop_Decay	mRNA_Surveillance	Non-Stop Decay	In eukaryotes, the non-stop decay mechanism recognizes and degrades mRNAs that lack a stop codon. It releases ribosomes stalled at the 3' end of a mRNA and stimulates the exosome to rapidly degrade the transcript. (from PubMed 12210514)
C29648	Nonsense-Mediated_Decay	mRNA_Surveillance	Nonsense-Mediated Decay	Nonsense-Mediated Decay is the widely conserved process in eukaryotes whereby certain alternatively spliced RNAs, some selenoprotein mRNAs, and nonsense or frame-shift mutations that result in premature translation termination signal rapid mRNA degradation; the mechanism that eliminates mRNAs with premature termination codons, reducing the accumulation of deleterious proteins and their effects. NMD is initiated during translation when hUpf proteins phosphorylated by SMG proteins cooperate with an exon-junction complex to identify mRNAs with premature stop codons and mark the transcript for rapid decay. Degrading mRNAs from both ends, NMD involves decapping, deadenylating, and exonucleolytic activities.
C29667	Body_Surface	Anatomic_Surface	Body Surface	The surface of an external body region.
C29668	Signal_Repression	Cell_Signaling_Process	Signal Repression	Repression of any of several ways in which living cells of an organism communicate with one another, whether by direct contact between cells or by means of chemical signals.
C29669	H19_Imprinted_Maternal_Untranslated_mRNA	Functional_RNA	H19 Imprinted Maternal Untranslated mRNA|H19	Maternally expressed exclusively and developmentally regulated human putative tumor suppressor H19 Gene encodes H19 Imprinted Maternal Untranslated mRNA. Expression in developing skeletal and smooth muscles correlates with specific differentiation events. It accumulates during skeletal muscle development with maximal adult expression and correlates with the nonproliferative, actin-positive muscle cell phenotype. Loss of H19 expression may be involved in Wilms tumorigenesis. (NCI)
C29670	G_Protein-Coupled_Receptor_39	Retired_Concepts	G Protein-Coupled Receptor 39|GPR39|Putative G Protein-Coupled Receptor GPR39	GPR39 is a single-copy gene, expressed in brain and other peripheral tissues. It encodes G Protein-Coupled Receptor 39, which has high homology to the growth hormone secretagogue receptor (GHSR), a G protein-coupled receptor found in the pituitary gland and brain that is involved in the control of growth hormone release. The ligand-binding and functional properties of GPR39 remain to be determined. (from OMIM and Genomics 1997;46:426-34)
C29671	G_Protein-Coupled_Receptor_54	Retired_Concepts	G Protein-Coupled Receptor 54|G Protein-Coupled Receptor|G Protein-Coupled Receptor AXOR12|G-Protein-Coupled Receptor GPR54|GPR54|Metastin Receptor	Encoded by human GPR54 Gene, 395-aa 43-kDa G Protein-Coupled Receptor 54 is a Gq/11-coupled receptor for endogenous KISS1 (Metastin), which appears to inhibit chemotaxis. (NCI)
C29672	TFIIA_Alpha-p55	Basal_Transcription_Factor	TFIIA Alpha p55|GTF2A1	Encoded by human GTF2A1 Gene, TFIIA Alpha p55 is a 55-kDa post-translationally processed precursor of the 35-kD alpha (N-terminal) and 19-kD beta (C-terminal) subunits of general transcription initiation factor TFIIA. These subunits and the 12-kDa gamma subunit (GTF2A2 Gene) form a six strand beta-barrel that interacts with TBP and a separate four-helix bundle positioned just upstream of the TBP-TATA complex. Accurate transcription initiation on class II genes involves ordered assembly of RNA polymerase II and general initiation factors. (NCI)
C29673	Transcription_Initiation_Factor-IIA_Alpha_Chain	Basal_Transcription_Factor	Transcription Initiation Factor IIA Alpha Chain|GTF2A1|TFIIA p35 Subunit	Encoded by human GTF2A1 Gene, Transcription Initiation Factor IIA Alpha Chain is a 35-kD subunit of general transcription initiation factor TFIIA that is post-translationally processed (N-terminal) with the 19-kD beta subunit (C-terminal) from the 55-kDa TFIIA Alpha p55 precursor. These subunits and the 12-kDa gamma subunit (GTF2A2 Gene) form a six strand beta-barrel that interacts with TBP and a separate four-helix bundle positioned just upstream of the TBP-TATA complex. Accurate transcription initiation on class II genes involves ordered assembly of RNA polymerase II and general initiation factors. (NCI)
C29674	Transcription_Initiation_Factor-IIA_Beta_Chain	Basal_Transcription_Factor	Transcription Initiation Factor IIA Beta Chain|GTF2A1|TFIIA p19 Subunit	Encoded by human GTF2A1 Gene, Transcription Initiation Factor IIA Beta Chain is a 19-kD subunit of general transcription initiation factor TFIIA that is post-translationally processed (C-terminal) with the 35-kD alpha subunit (N-terminal) from the 55-kDa TFIIA Alpha p55 precursor. These subunits and the 12-kDa gamma subunit (GTF2A2 Gene) form a six strand beta-barrel that interacts with TBP and a separate four-helix bundle positioned just upstream of the TBP-TATA complex. Accurate transcription initiation on class II genes involves ordered assembly of RNA polymerase II and general initiation factors. (NCI)
C29675	Transcription_Initiation_Factor-IIA_Gamma_Chain	Basal_Transcription_Factor	Transcription Initiation Factor IIA Gamma Chain|GTF2A2|General Transcription Factor IIA2 12kDa|TFIIA p12 Subunit|TFIIA-12|TFIIA-Gamma|TFIIAS	Encoded by human GTF2A2 Gene, Transcription Initiation Factor IIA Gamma Chain is the 12-kD gamma subunit of TFIIA, along with 35-kD alpha and 19-kD beta subunits. Accurate transcription initiation on class II genes involves ordered assembly of RNA polymerase II and general initiation factors. The first step involves TATA box recognition by TBP, which may be regulated by TFIIA, a factor that interacts with both TBP and a TAF in TFIID. The TFIIA subunits form a six strand beta-barrel that interacts with TBP and a separate four-helix bundle positioned just upstream of the TBP-TATA complex. (NCI)
C29676	General_Transcription_Factor-TFIIB	Basal_Transcription_Factor	General Transcription Factor TFIIB|GTF2B|General Transcription Factor IIB|RNA Polymerase II Transcription Factor IIB|S300-II|Transcription Initiation Factor IIB	Encoded by human TFIIB Gene, ubiquitous nuclear General Transcription Factor TFIIB plays a central role in assembly of the preinitiation complex, required for transcription initiation by RNA polymerase II. Sequence-specific DNA-binding TFIIB forms the DAB complex with promoter-bound TFIID and TFIIA, bridging TFIID and RNA Polymerase II. TFIIB interacts with the promoter TFIIB-recognition element BRE. BRE suppresses basal transcription by a core promoter, which increases transcription in the presence of an activator that can disrupt promoter-bound TFIIB-BRE. (NCI)
C29677	Transcription_Initiation_Factor-IIE_Alpha_Subunit	Basal_Transcription_Factor	Transcription Initiation Factor IIE Alpha Subunit|GTF2E1|General Transcription Factor IIE 56 kDa Subunit|General Transcription Factor IIE1 Alpha 56kDa|TFIIE-Alpha	Encoded by human GTF2E1 Gene, 56-kD Transcription Initiation Factor IIE Alpha Subunit is the alpha subunit of RNA polymerase II TFIIE. GTF2E1 appears required with GTF2E2 for stable formation of a preinitiation complex and for basal, as well as Sp1-activated, transcription. (NCI)
C29678	Transcription_Initiation_Factor-IIF_Alpha_Subunit	Basal_Transcription_Factor	Transcription Initiation Factor IIF Alpha Subunit|GTF2F1|General Transcription Factor IIF1 74kDa|TFIIF-Alpha|Transcription Initiation Factor RAP74	Encoded by human GTF2F1 Gene, 74-kD Transcription Initiation Factor IIF Alpha Subunit is the large subunit of general transcription TFIIF, participating in initiation by RNA polymerase II. TFIIF binds to RNA polymerase II decreasing its affinity for nonspecific DNA and acts at an intermediate stage in initiation complex formation after TFIID associates with DNA, as RNA polymerase II binds to DNA, and before recruitment of TFIIE. GTF2F1 interacts with GTF2F2 to direct transcription initiation and is necessary for transcriptional activation by SRF. (NCI)
C29679	Transcription_Initiation_Factor-IIF_Beta_Subunit	Basal_Transcription_Factor	Transcription Initiation Factor IIF Beta Subunit|GTF2F2|General Transcription Factor IIF2 30kDa|TFIIF-Beta|Transcription Initiation Factor RAP30	Encoded by human GTF2F2 Gene, 30-kD Transcription Initiation Factor IIF Beta Subunit is the small subunit of transcription factor TFIIF. By distinct functional domains, TFIIF affects RNA polymerase II during initiation and elongation. It assists TFIIB in recruiting RNA polymerase II into a preinitiation complex and suppresses transient polymerase pausing. TFIIF beta initiation activity is mediated by a DNA-binding C-terminal domain. Elongation is mediated by sequences upstream of the C-terminus, where RNA polymerase II may bind, as well as by sequences near the N-terminus. (NCI)
C29680	General_Transcription_Factor-IIH1-62kDa	Basal_Transcription_Factor	General Transcription Factor IIH1 62kDa|BTF2-p62|Basic Transcription Factor 62kDa Subunit|GTF2H1|General Transcription Factor IIH1|TFIIH Basal Transcription Factor Complex p62 Subunit	Expressed in testis by human GTF2H1 Gene, General Transcription Factor IIH1 62kDa is a subunit of TFIIH, a multisubunit factor of at least 10 proteins involved in transcription, nucleotide excision repair, and cell cycle regulation. p62 is one of six subunits that constitutes the TFIIH core; the holoenzyme contains the ternary kinase CAK complex. Lacking any known motifs or enzymatic activity p62 may have only an architectural role. (NCI)
C29681	General_Transcription_Factor-IIIC1_Alpha_Subunit	Basal_Transcription_Factor	General Transcription Factor IIIC1 Alpha Subunit|GTF3C1|General Transcription Factor IIIC1 Alpha 220kDa|TFIIIC|TFIIIC Alpha|TFIIIC220	Encoded by human GTF3C1 Gene, 220-kD General Transcription Factor IIIC1 Alpha Subunit is a subunit of general transcription factor GTF3C, a component of RNA polymerase III. GTF3C is a multisubunit complex that binds B box promoter elements; GTF3C1 binds to the box B. GTF3C1 is absolutely required for RNA polymerase III transcription of 5S RNA, tRNA, and VAI RNA genes. (NCI)
C29682	General_Transcription_Factor-IIIC2_Beta_Subunit	Basal_Transcription_Factor	General Transcription Factor IIIC2 Beta Subunit|GTF3C2|General Transcription Factor IIIC2 Beta 110kDa|TFIIIC-Beta|TFIIIC110	Encoded by human GTF3C2 Gene, 110-kD ubiquitous General Transcription Factor IIIC2 Beta Subunit is the beta subunit of general transcription factor GTF3C, a component of RNA polymerase III and essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA. To initiate RNA synthesis, RNA polymerases need GTFs to assemble in a promoter-bound complex and recruit RNA polymerase. GTF3C2 contains stretches of acidic and basic regions, potential acidic and basic helices, and 5 putative WD40 repeats. (NCI)
C29683	General_Transcription_Factor-IIIC3-102kDa	Basal_Transcription_Factor	General Transcription Factor IIIC3 102kDa|GTF3C3|TFIIIC Gamma|TFIIIC102|Transcription Factor IIIC 102kD	Encoded by human GTF3C3 Gene, General Transcription Factor IIIC3 102kDa is a subunit of GTF3C and contains N-terminal basic and acidic regions, a central acidic region, a C-terminal helix-loop-helix region, and 11 tetratricopeptide repeats. The GTF3C complex interacts with GTF3B in the recruitment of RNA polymerase III. (NCI)
C29684	General_Transcription_Factor-IIIC4-90kDa	Basal_Transcription_Factor	General Transcription Factor IIIC4 90kDa|GTF3C4|TFIII90|TFIIIC Delta|TFIIIC90	Encoded by human GTF3C4 Gene, General Transcription Factor IIIC4 90kDa is a subunit of general transcription factor GTF3C, a component of RNA polymerase III and essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA. To initiate RNA synthesis, RNA polymerases need GTFs to assemble in a promoter-bound complex and recruit RNA polymerase. GTF3C4 interacts with GTF3B in recruiting RNA polymerase III and has histone acetyltransferase activity. GTF3C4 contains 2 C-terminal zinc fingers. (NCI)
C29685	General_Transcription_Factor-IIIC5-63kDa	Basal_Transcription_Factor	General Transcription Factor IIIC5 63kDa|GTF3C5|TFIIIC Epsilon|TFIIIC63|Transcription Factor IIIC 63 kD	Encoded by human GTF3C5 Gene, General Transcription Factor IIIC5 63kDa is a subunit of general transcription factor GTF3C, a component of RNA polymerase III and essential for RNA polymerase III to make a number of small nuclear and cytoplasmic RNAs, including 5S RNA, tRNA, and adenovirus-associated (VA) RNA. To initiate RNA synthesis, RNA polymerases need GTFs to assemble in a promoter-bound complex and recruit RNA polymerase. GTF3C complex interacts with GTF3B in recruiting RNA polymerase III. GTF3C5 contains a central helix-turn-helix motif and a C-terminal acidic region. (NCI)
C29686	Transcription_Initiation_Factor-IIE_Beta_Subunit	Basal_Transcription_Factor	Transcription Initiation Factor IIE Beta Subunit|GTF2E2|General Transcription Factor IIE2 Beta 34kDa|TFIIE-Beta	Encoded by human GTF2E2 Gene, 34-kD Transcription Initiation Factor IIE Beta Subunit appears to be required for formation of a stable preinitiation complex for RNA polymerase II, as well as for basal-level and Sp1-activated transcription. (NCI)
C29687	Putative_GR6_Protein	Protein_with_Unknown_or_Unclassified_Function	Putative GR6 Protein|GR6|GR6 Protein	Normally expressed in early fetal development by human GR6 Gene, the function of 149-aa 16-kDa Putative GR6 Protein is unknown. (NCI)
C29688	GR6_Protein	Retired_Concepts	GR6 Protein|GR6	Encoded by human GR6 Gene, the function of 149-aa 16-kDa GR6 Protein is unknown. (NCI)
C29689	Jumping_Translocation_Breakpoint_Protein	Transmembrane_Protein	Jumping Translocation Breakpoint Protein|JTB|JTB Protein|PAR Protein|Prostate Androgen Regulated Protein	Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomal segments jumping to various telomeres. The JTB gene (jumping translocation breakpoint) is found fused with the telomeric repeats of acceptor telomeres in a case of jumping translocation. Jumping Translocation Breakpoint is encoded by this open reading frame, and is highly conserved among divergent eukaryotic species.  JTB is a 146-aa protein with a 75-aa extracellular domain, a 21-aa transmembrane domain, and a 20-aa intracellular domain.  Jumping translocations have been reported in leukemia patients, in the Ewing family of tumors, in renal clear cell carcinoma, and in liposarcoma. (from OMIM)
C29690	Oligonucleotide_Linker	Retired_Concepts	Oligonucleotide Linker	Synthetic linkers used to generate nucleic acid miniduplexes that are capable of binding to nucleic acid-binding proteins.(NCI)
C29692	Merphalen	Retired_Concepts	Merphalen
C29693	Skin_Test_Vaccine	Retired_Concepts	Skin Test Vaccine	A preparation of an antigenic component of an infectious agent that is administered to a patient in order to determine whether previous exposure to the agent has occurred, and/or to assess the integrity of the patient's cellular immune system.  Depending on the clinical situation, the appearance of a delayed (cellular) hypersensitivity response, which manifests as an area of induration and erythema at the injection site, i.e. a positive test result, may indicate previous exposure to a particular infectious agent. (NCI04)
C29694	Inactivated_Vaccine	Vaccine	Inactivated Vaccine|Inactivated Virus Vaccine	A preparation of killed microorganisms that is intended to prevent or treat an infectious disease by inducing active immunity to the causative microorganism. (NCI04)
C29695	Yttrium_90_Monoclonal_Antibody_T101	Radioimmunoconjugate	Yttrium 90 Monoclonal Antibody T101|MOAB YT-90 T101	A murine monoclonal antibody directed against the CD5 antigen and labeled with Yttrium-90, a beta-emitting radioisotope. CD5 is a type-I transmembrane glycoprotein found on thymocytes, T-cells and a subset of B-cells. Yttrium 90 monoclonal antibody T101 may bind to and selectively irradiate and kill CD5-positive tumor cells. Yttrium 90 has a half-life of 2.5 days and can be administered on an outpatient basis. (NCI04)
C29696	Muscle_Relaxant	Adjuvant	Muscle Relaxant
C29697	Laxative	Adjuvant	Laxative
C29698	Antispasmotic_Agent	Adjuvant	Antispasmodic Agent	Natural or synthetic Antispasmodic Agents (commonly anticholinergic) relieve spasms or cramps of the stomach, intestines, and bladder. These agents often decrease secretions (acid and enzymes) and movements of the stomach and intestine. (NCI04)
C29699	Stool_Softener	Adjuvant	Stool Softener
C29700	Astringent	Adjuvant	Astringent	With a binding, contracting action on mucous membranes, skin, and other tissues, Astringent substances reduce irritation and inflammation; create a barrier against infection; help wounds and burns to heal; arrest secretion; and control bleeding. (NCI04)
C29701	Anti-ulcer_Agent	Adjuvant	Anti-ulcer Agent	Natural or synthetic Anti-ulcer Agents relieve and reduce the symptoms of ulcers in the stomach and upper small intestine, systemically and locally, by reducing gastric secretion (proton pump inhibitors), neutralizing hyperacidity (alkalinizing agents), or improving healing and protecting the mucosa (sucralfate). Recurrent gastric and duodenal ulcers caused by Helicobacter pylori infections are treated with antibiotic therapy. (NCI04)
C29702	Histamine-2_Receptor_Antagonist	Anti-ulcer_Agent	Histamine-2 Receptor Antagonist
C29703	Anti-lipidemic_Agent	Adjuvant	Antilipidemic Agent	Natural or synthetic Anti-lipidemic Agents reduce plasma lipids, such as cholesterol or low density lipoproteins (LDL), acting systemically or locally (intestines) to decrease fat digestion, absorption, production, and accumulation in the plasma and reducing pathogenic atherosclerosis and thrombosis. Cholestyramine, fibrates, nicotinic acid and HMG-CoA reductase inhibitors are examples of anti-lipidemic agents. (NCI04)
C29704	Antimuscarinic_Agent	Adjuvant	Antimuscarinic Agent	Natural or synthetic Antimuscarinic Agents inhibit acetylcholine neurotransmitter action at muscarinic receptors. Antimuscarinic drugs are used as antiarrhythmic, antiparkinson, antiasthmatic, and antispasmodic agents, as well as antidote of the natural mushroom alkaloid muscarine (Amanita muscaria) or to prevent parasympathetic stimulation at neuroeffector junctions. (NCI04)
C29705	Anti-glaucoma_Agent	Adjuvant	Anti-glaucoma Agent	Natural or synthetic Anti-glaucoma Agents relieve or prevent glaucoma, a condition characterized by increased intraocular pressure, excavation, and optic nerve damage. Such an agent may decrease ocular pressure and improve glaucoma as a beta-adrenergic blocker, a parasympathomimetic, an alpha-adrenergic agonist, a prostaglandin synthesis agonist, or by other mechanisms. (NCI04)
C29706	Mydriatic_Agent	Adjuvant	Mydriatic Agent
C29707	Vasodilating_Agent	Adjuvant	Vasodilating Agent
C29708	Anti-psoriatic_Agent	Adjuvant	Anti-psoriatic Agent	Used topically or systemically, natural or synthetic Anti-psoriatic agents relieve symptoms of psoriasis by controlling rapid growth of skin cells, reducing DNA synthesis and mitotic activity in hyperplastic epidermis, and restoring normal epidermal cell proliferation and keratinization. (NCI04)
C29709	Alpha-adrenergic_Agonist	Adrenergic_Agent	Alpha-Adrenergic Agonist	Natural or synthetic Alpha-adrenergic Agonists selectively bind to and activate alpha adrenergic receptors of the sympathetic nervous system, mimicking the actions of natural sympathomimetic neurotransmitters (norepinephrine and related substances). Alpha-adrenergic Agonists can initiate physiological responses such as vasoconstriction, pupil dilation, and contraction of pilomotor muscles. (NCI04)
C29710	Antipsychotic_Agent	Adjuvant	Antipsychotic Agent	Also known as neuroleptics, major tranquilizers, or antischizophrenics, natural or synthetic Antipsychotic Agents relieve and control the symptoms of schizophrenic illness (hallucinations, delusions, dementia). Most antipsychotic agents interfere with various neurotransmitter functions, often blocking dopamine receptors, and induce diverse behavioral, endocrine, motor-kinetic effects. (NCI04)
C29711	Anti-diabetic_Agent	Adjuvant	Anti-diabetic Agent	By supplying insulin or stimulating endogenous insulin production, natural or synthetic Anti-diabetic Agents relieve diabetes, reducing and controlling blood sugar levels. Most current insulin products are obtained by recombinant DNA technology and mimic natural insulin. Oral hypoglycemic agents that stimulate pancreatic insulin production and increase glucose uptake in various tissues mainly belong to sulfonylurea and biguanide classes. (NCI04)
C29712	Anti-asthmatic_Agent	Adjuvant	Anti-asthmatic Agent	Classified as bronchodilators (beta-adrenoreceptor agonists, xanthines, muscarinic-receptor antagonists) and anti-inflammatory agents (glucocorticoids, cromolyn), natural or synthetic Anti-asthmatic Agents relieve asthma (a recurrent airway obstruction) in multiple ways and at various sites, by reducing bronchial spasm, dyspnea, allergic reaction, local inflammation, and pain. Other agents, such as anti-histamine and antibiotics, may also be used in asthma. (NCI04)
C29713	Alpha-adrenergic_Blocking_Agent	Adrenergic_Agent	Alpha-Adrenergic Antagonist|Alpha-adrenergic Blocking Agent	Natural or synthetic Alpha-adrenergic Blocking Agents selectively bind to adrenergic receptors, or compete with natural adrenergic mediators, and inactivate alpha adrenergic receptors of the sympathetic nervous system. These agents block the action of natural sympathomimetic neurotransmitters (norepinephrine and related substances), and can initiate physiological responses such as vasodilation, bradycardia, and pupil contraction. (NCI04)
C29714	Mast_Cell_Stabilizer	Anti-asthmatic_Agent	Mast Cell Stabilizer
C29715	Gastrointestinal_Lipase_Inhibitor	Enzyme_Inhibitor	Gastrointestinal Lipase Inhibitor	An agent that inhibits lipases expressed by gastric and pancreatic epithelial cells.  Typically, a gastrointestinal lipase inhibitor binds to lipases, blocks their activities and results in a diminished digestion and absorption of dietary fat. (NCI04)
C29716	Antihistamine	Adjuvant	Antihistamine	As an antidote to histamine exposure, natural or synthetic Antihistamines block the deleterious effects of histamine overactivity, especially in allergic conditions. By competing with and displacing histamine from H1 and H2 receptors, they reduce inflammation, irritation, vasodilation, hypersecretion, and smooth muscle spasms induced by histamine. (NCI04)
C29717	DNA_Compaction_Peptide	Gene_Therapy_Agent	DNA Compaction Peptide	A synthetic peptide used to formulate and deliver deoxyribonucleic acids (DNA, usually in plasmid form) in gene therapy.  The carrier peptides may condense plasmids into nano-particles with a hydrodynamic diameter ranging from 40 to 200 nm, which are sterically stable for long periods of time.  Peptide-based gene delivery systems are used for transfection in a variety of cell lines. (NCI04)
C29719	Smoking_History	Personal_Medical_History	Smoking History	A record of an individual's background in regard to smoking tobacco.  This would include such factors as start date, end date (if applicable), number of cigarette smoked, attempts to quit, and others.
C29721	Monoclonal_Antibody_to_Colorectal_Cancer	Monoclonal_Antibody	Monoclonal Antibody to Colorectal Cancer|MOAB Colorectal Carcinoma	A monoclonal antibody (MOAB) directed against an antigen expressed by colorectal cancer cells. (NCI04)
C29722	Hypotensive_Agent	Adjuvant	Hypotensive Agent
C29723	Proton_Pump_Inhibitor	Anti-ulcer_Agent	Proton Pump Inhibitor
C29724	Cyanoglycoside_Agent	Antineoplastic_Plant_Product	Cyanoglycoside Agent
C29725	Conjugating_Agent	Drug_Vehicle	Conjugating Agent
C29726	Enzyme_Replacement_Preparation	Combination_Medication	Enzyme Replacement Preparation
C29727	Pediculocide	Adjuvant	Pediculicide
C29728	Anorexiant	Adjuvant	Anorexiant	The term anorexiant describes the category of drug whose original or most common use and intended therapeutic effect is to prevent weight gain or to promote weight loss by reducing appetite for food. (http://www.behavenet.com/capsules)
C29729	Alkalinizing_Agent_Preparation	Combination_Medication	Alkalinizing Agent Preparation	Used topically or systemically for management of metabolic acidosis, improved muscle contraction, and hyper-acidic conditions, Alkalinizing Agent Preparations contain one or more substances with basic properties, such as sodium bicarbonate, sodium citrate, and phosphate salts (potassium phosphate, sodium acid phosphate, and tribasic sodium phosphate). Usually the alkalinizing agent(s) acts as a proton acceptor, neutralizing the acidity of a biologic environment (skin, gastric content, urine, etc.) and raising the pH. (NCI04)
C29730	Electrolyte_Replacement_Agent	Adjuvant	Electrolyte Replacement Agent
C29731	Hormone_Replacement_Preparation	Combination_Medication	Hormone Replacement Preparation
C29733	Antigout_Preparation	Combination_Medication	Anti-gout Preparation	Pharmaceutical Anti-gout Preparations such as colchicine, allopurinol, probenecid, and sulfinpyrazone contain natural or synthetic agents against gout, a condition characterized by increased uric acid accumulation. Anti-gout agents may reduce inflammation, stimulate elimination of uric acid, or increase production of uric acid. (NCI04)
C29734	Hemmorrhoidal_Preparation	Combination_Medication	Hemmorrhoidal Preparation
C29736	Stress-Induced_Protein	Protein_Organized_by_Function	Stress-Induced Protein	Stress-Induced Proteins are activated in states of physiological strain caused by adverse internal or external stimuli that disturb the functioning of an organism.
C29737	_11q23_1-q23_3	Chromosome_Band	11q23.1-q23.3	A chromosome band present on 11q
C29738	Antiflatulent_Agent	Adjuvant	Antiflatulent Agent	Natural or synthetic compounds usually administered orally, Antiflatulent Agents relieve or prevent flatulence, excess gas in the stomach and intestines, by adsorbing the gas, stimulating intestinal elimination of gas, or preventing gas formation. Alpha-galactosidase and activated charcoal are used against flatulence. (NCI04)
C29739	Sulfonamide_Anti-infective_Agent	Anti-Infective_Agent	Sulfonamide Anti-infective Agent	A natural or synthetic sulfanilamide derivative, an antibacterial Sulfonamide Anti-infective Agent is a structural analogue of para-aminobenzoic acid (essential for microbial folate synthesis). Sulfonamides inhibit bacterial metabolism by competing with PABA for dihydropteroate synthetase, involved in folate synthesis. As a bacteriostatic, rather than bactericidal, agent it is effective in the presence of adequate host defenses. (NCI04)
C29740	Interleukin-17C	Interleukin	Interleukin-17C|Cytokine CX2|IL-17C|IL-21|IL17C	Expressed in activated T cells by human IL17C Gene (IL-17 Family), 197-aa 22-kDa (precursor) secreted cytokine Interleukin-17C (IL17-related) may stimulate release of TNF-alpha and IL-1beta from monocytes in inflammatory immune responses. IL17C differs from IL17 in its pattern of expression, biologic activity, and lack of interaction with IL17 receptor. (NCI)
C29744	Formaldehyde	Organic_Carcinogen|Reagent	Formaldehyde|Formalin|Formic Aldehyde|Formol|Methanal|Methyl Aldehyde|Oxomethane|formaldehyde	(for-MAL-duh-hide) A chemical used in manufacturing and chemical industries, and by anatomists, embalmers, and pathologists.  Exposure to formaldehyde may increase the risk of developing leukemia and brain cancer.
C29745	Metastin	Protein_Fragment	Metastin|KISS1	Metastin, encoded by the KISS1 Gene, is a placental truncated C-terminally amidated peptide form of KiSS1 Metastasis Suppressor Protein. Metastin is an endogenous ligand of orphan GPR54 (GPCR) and appears to inhibit chemotaxis and metastasis. (NCI)
C29747	Adrenergic_Agent	Adjuvant	Adrenergic Agent	Refer to a class of agents that acts upon adrenergic receptors associated with activities of Sympathetic Nerve System. The adrenergic receptors (adrenoceptors) belongs to the family of seven membrane spanning domain receptors that require G protein signaling pathway. (NCI04)
C29748	Interleukin-1_Receptor-Associated_Kinase-1	Serine-Threonine_Protein_Kinase|Signaling_Protein	Interleukin-1 Receptor-Associated Kinase 1|IRAK-1|IRAK1|Pelle Homolog	Encoded by human IRAK1 Gene (Pelle Ser/Thr Kinase Family), ubiquitous 712-aa 77-kDa Interleukin-1 Receptor-Associated Kinase 1 is one of two putative Ser/Thr kinases that rapidly associate with the Interleukin-1 Receptor (IL1R) upon stimulation. IRAK phosphorylation occurs after association with IL1-R-1, which may activate the kinase. Found in a complex containing TRAF6, PELI1 and IRAK4, IRAK1 interacts with PELI2 and PELI3. IRAK1 is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. (NCI)
C29749	Interleukin-1_Receptor-Associated_Kinase-2	Serine-Threonine_Protein_Kinase|Signaling_Protein	Interleukin-1 Receptor-Associated Kinase 2|IRAK-2|IRAK2	Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas, and peripheral leukocytes by human IRAK2 Gene (Pelle Ser/Thr Kinase Family), 590-aa 65-kDa Interleukin-1 Receptor-Associated Kinase 2 is one of two putative Ser/Thr kinases that rapidly associate with the Interleukin-1 Receptor (IL1R) upon stimulation. IRAK2 interacts with TRAF6 and is required for IL1R-induced NF-Kappa-B activation. (NCI)
C29750	Thrombolytic_Agent	Adjuvant	Thrombolytic Agent
C29751	Interleukin-1_Receptor-Associated_Kinase-3	Signaling_Protein	Interleukin-1 Receptor-Associated Kinase 3|IRAK3|IRAKM|Interleukin-1 Receptor-Associated Kinase M	Expressed in peripheral leukocytes and monocytes by human IRAK3 Gene, 596-aa Interleukin-1 Receptor-Associated Kinase 3 contains an N-terminal death domain and central kinase domain. IRAK3 appears to activate NF-kappa-B via IL1R. IRAK3 interacts with MYD88 and TRAF6 signaling proteins in a manner similar to the other IRAKs. It prevents dissociation of IRAK and IRAK4 from MYD88 and formation of IRAK/TRAF6 complexes. But IRAK3 does not autophosphorylate in the manner of IRAK1. IRAK1, -2, and -3 mediate the TLR2-dependent response to lipopolysaccharide. IRAK3 is induced upon TLR stimulation and negatively regulates TLR signaling. (NCI)
C29752	Interleukin-1_Receptor-Associated_Kinase-4	Signaling_Protein	Interleukin-1 Receptor-Associated Kinase 4|IRAK4|REN64	Widely expressed (strongest in kidney and liver) by human IRAK4 Gene, 460-aa Interleukin-1 Receptor-Associated Kinase 4 contains (like IRAK1, IRAK2, IRAKM, and Pelle) an N-terminal death domain and a central kinase domain. Similar to Pelle, IRAK4 has a short C-terminal domain. Like all IL1R-associated kinases, IRAK4 mediates Toll/IL1R family receptor signal transduction. Like IRAK1 and Pelle, IRAK4 has auto- and cross-phosphorylation activity. IRAK4 phosphorylates and activates IRAK1. It also interacts with MYD88 and TRAF6 and activates MAPK and NF kappa-B pathways. IRAK4 may act as an IRAK1 kinase, triggering phosphorylation cascades. (NCI)
C29753	IL2-Inducible_T-Cell_Kinase	Protein_Tyrosine_Kinase|Signaling_Protein	IL2-Inducible T-Cell Kinase|EMT|Kinase EMT|LYK|PSCTK2|T-Cell ITK/TSK Homolog|T-Cell-Specific Kinase|Tyrosine-Protein Kinase ITK/TSK|Tyrosine-Protein Kinase LYK	Expressed in T-cells and natural killer cells by interleukin-2-induced ITK Gene (TEC Tyr Kinase Family), 620-aa 72-kDa intracellular IL2-Inducible T-Cell (tyrosine) Kinase contains an SH2, SH3, and PH domain, appears to localize to cell surface receptors (TCR,CD28, CD2) after stimulation, and plays a role in T-cell proliferation and differentiation. (NCI)
C29754	Inositol-1-4-5-Triphosphate_Receptor_Type-1	Receptor	Inositol 1,4,5-Triphosphate Receptor Type 1|IP3 Receptor Isoform 1|IP3R|IP3R1|InsP3R1|Type 1 Inositol 1,4,5-Trisphosphate Receptor|Type 1 InsP3 Receptor	Widely expressed by human ITPR1 Gene (InsP3R Family) as 8 potential alternative isoforms, 2758-aa 314-kDa integral endoplasmic reticulum membrane protein Inositol 1,4,5-Triphosphate Receptor Type 1 mediates release of intracellular calcium in response to second messenger inositol 1,4,5-trisphosphate. A likely homotetramer, the receptor contains 5 MIR domains, a large N-terminal ligand-binding cytoplasmic region, and central modulatory sites immediately upstream of the C-terminal calcium channel. Calcium appears to inhibit ligand binding to the receptor, perhaps by interaction with an inhibitory calcium-binding protein. Phosphorylation may prevent ligand-induced opening of the calcium channel. ITPR1 interacts with TRPC4 and is phosphorylated by c-AMP kinase. (NCI)
C29756	Sedative_and_Hypnotic	Adjuvant	Sedative and Hypnotic
C29757	RAD54B_Homolog_Protein	DNA_Repair_Protein	RAD54B Homolog|RAD54B|RAD54B Protein	Highly expressed in testis and spleen by human RAD54B Gene (SNF2/SWI2 Family), the two isoforms of 910-aa 100-kD nucleoplasmic RAD54B Homolog exhibit significant homology to RAD54 and motifs similar to DNA and RNA helicases. RAD54B binds to double-stranded DNA and displays DNA-associated ATPase activity. RAD54B appears to associate indirectly with RAD51 through its N-terminal domain and may colocalize with RAD54 and BRCA1. Part of a complex involved in meiotic and mitotic homologous DNA recombination repair, RAD54B plays a critical role in targeted integration and recombination in concert with other RAD52 epistasis group members without affecting cell growth, sensitivity to DNA damaging agents, or sister chromatid exchange. (NCI)
C29758	RAS-Related_GTP-Binding_Protein-RAGA	Protein_with_Unknown_or_Unclassified_Function	RAS-Related GTP-Binding Protein RAGA|RAS-Related GTP Binding A|RAS-Related GTP-Binding Protein|RRAGA	Encoded by human RAGA Gene, RAS-Related GTP-Binding Protein RAGA is a RAS-related GTP-binding protein lacking GTPase activity that interacts with adenovirus E3 protein and may be part of the TNF Alpha signaling pathway. (NCI)
C29759	Renal_Tumor_Antigen	Mitogen-Activated_Protein_Kinase	Renal Tumor Antigen|MOK Protein Kinase|RAGE|RAGE1	Expressed in heart, brain, lung, kidney, pancreas, placenta, liver, and skeletal muscle by human RAGE Gene (MAPK Family), 419-aa cytoplasmic Renal Tumor Antigen is 84% identical overall to the mouse protein (96% identical in the kinase domain) and structurally similar to other MAPKs, including a TEY motif in the activation loop that probably requires autophosphorylation and is required for kinase activity. MOK phosphorylates myelin basic protein. (NCI)
C29760	Retinoic_Acid_Induced-3_Protein	G_Protein-Coupled_Receptor	Retinoic Acid Induced 3|GPRC5A|RAI3|RAIG1	Encoded by human RAI3 Gene (GPCR3 Family), 357-aa 40-kDa Retinoic Acid Induced 3 protein contains 7 predicted GPCR-signature transmembrane domains and a potential N-linked glycosylation site. Likely involved in the interaction between retinoid acid and G protein signaling pathways, RAI3 may play a role in embryonic development and epithelial cell differentiation. (NCI)
C29761	RAL_Guanine_Nucleotide_Dissociation_Stimulator	Guanine_Nucleotide_Exchange_Factor	RAL Guanine Nucleotide Dissociation Stimulator|RALGDS|RALGEF|RGF	Encoded by human RALGDS Gene, 914-aa 101-kDa RAL Guanine Nucleotide Dissociation Stimulator is a guanine nucleotide exchange factor containing an N-terminal RAS-GEF domain and a noncatalytic C-terminal RAS-associating domain. RALGDS interaction as an effector molecule with RAS-like molecules is specific and dependent on RAS activation by GTP. RALGDS stimulates dissociation of GDP from RAS-related RALA and RALB GTPases, allowing GTP binding and GTPase activation. (NCI)
C29762	RAN_GTPase_Activating_Protein-1	GTPase-Activating_Protein	RAN GTPase Activating Protein 1|FUG1|MGC20266|RANGAP1	RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle. (LocusLink)
C29763	RAS-Related_Protein-RAP1A	Signaling_Protein	RAS-Related Protein RAP1A|C21KG|G-22K|GTP-Binding Protein SMG-P21A|KREV-1 Protein|RAP1A|RAP1A Member of RAS Oncogene Family|SMGP21	Encoded by human RAP1A Gene (RAS GTPase Family), 184-aa 21-kDa (precursor) membrane-bound RAS-Related Protein RAP1A is activated by guanine nucleotide-exchange factors EPAC and EPAC2, in a cAMP-dependent manner, and by GFR. Interacting with RAS GAPs and RAF in a competitive manner, RAP1A counteracts RAS mitogenic function. (NCI)
C29764	Retinoic_Acid_Receptor_Beta	Retinoic_Acid_Receptor	Retinoic Acid Receptor Beta|HBV-Activated Protein|Hepatitis B Virus Activated Protein|RAR-Beta|RAR-Epsilon|RARB|Retinoic Acid Receptor Beta 2|Retinoic Acid Receptor Beta 4	Encoded by human RARB Gene (NR1 Family), alternative isoforms of Retinoic Acid Receptor Beta (1-4) are composed of three domains: an N-terminal modulating domain, a central DNA-binding domain, and a C-terminal ligand-binding domain. RARB controls embryonic morphogenesis, cell proliferation, and differentiation by directly regulating gene transcription. RARB appears to limit growth of many cell types. (NCI)
C29765	Retinoic_Acid_Receptor_Responder_Protein-3	Signaling_Protein	Retinoic Acid Receptor Responder Protein 3|RAR-Responsive Protein TIG3|RARRES3|Retinoid Inducible Gene 1 Protein|Tazarotene-Induced Gene 3 Protein	Expressed in many tissues, human RARRES3 Gene (H-REV107 Family) at 11q23 encodes 164-aa 18-kDa Retinoic Acid Receptor Responder Protein 3 thought act as a regulator that mediates some of the growth inhibitory and cell differentiation activities of retinoids. RARRES1, RARRES2, and RARRES3 genes are upregulated by the synthetic retinoid tazarotene. (NCI)
C29766	Activator_of_G-Protein_Signaling_1_Protein	Signaling_Protein	Activator of G-Protein Signaling 1|AGS1|Activator of G Protein Signaling|DEXRAS1|Dexamethasone-Induced RAS-Related Protein 1|RAS-Related Protein|RASD1	Expressed in a variety of tissues (heart strongest), human RASD1 Gene (RASD GTPase Family) at 17p11.2 encodes 281-aa 32-kDa Activator of G-Protein Signaling 1, a dexamethasone inducted RAS-related protein that may play a role in alterations of cell morphology, growth, and cell-extracellular matrix interactions. RASD1 may form a ternary complex with CAPON and NOS1 and may function as a physiologic nitric oxide (NO) effector. (NCI)
C29767	Expectorant	Adjuvant	Expectorant
C29768	_1-Aminobenzo_a_pyrene	Polycyclic_Aromatic_Hydrocarbons	1-Aminobenzo[a]pyrene|1-ABaP
C29769	Estradiol_Benzoate	Therapeutic_Estradiol	Estradiol Benzoate|(17beta)-Estra-1,3,5(10)-triene-3,17-diol 3-Benzoate	The synthetic benzoate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.  As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors.  This agent exhibits mild anabolic and metabolic properties, and increases blood coagulability. (NCI04)
C29770	Estradiol_Dipropionate	Therapeutic_Estradiol	Estradiol Dipropionate|(17beta)-Estra-1,3,5(10)-triene-3,17-diol Dipropanoate	The synthetic dipropionate ester of estradiol, a steroid sex hormone vital to the maintenance of fertility and secondary sexual characteristics in females.  As the primary, most potent estrogen hormone produced by the ovaries, estradiol binds to and activates specific nuclear receptors.  This agent exhibits mild anabolic and metabolic properties, and increases blood coagulability. (NCI04)
C29771	Horse_Anti-mouse_Anti-lymphocyte_Serum	Therapeutic_Immune_Globulin	Horse Anti-mouse Anti-lymphocyte Serum|HALS	Heterologous antisera to mouse lymphocytes produced in horses and used to treat or prevent transplant rejection.  These polyclonal antisera produced by immunization of horses with mice splenocytes exhibit some general anti-leucocyte activity as well as some antiplatelet activity and may produce varying degrees of leucopenia or thrombocytopenia; the primary effect of anti-lymphocyte antisera is to reduce the T-lymphocyte count.  Antibodies directed against lymphocytes are among the most potent immunosuppressive agents available for organ transplantation. (NCI04)
C29772	Normal_Horse_Serum	Therapeutic_Immune_Globulin	Normal Horse Serum|NHS	The serum of a healthy, unvaccinated adult horse.  Sera are lipid-extracted, dialyzed, sterilized, and filtered and may contain preservatives such as sodium azide.  Normal horse serum may be used as a blocking agent to reduce background from non-specific binding or as a negative control in immunoassays. (NCI04)
C29773	Pregnant_Mare_Serum_Gonadotropin	Biological_Agent	Pregnant Mare Serum Gonadotropin|Equine Chorionic Gonadotropin|Equine gonadotropin|PMSG|eCG	A polypeptide hormone isolated from the equine placenta. In animals, the activity of pregnant mare serum gonadotropin is similar to that of follicle-stimulating hormone; in humans, this agent is relatively ineffective. This agent is used in veterinary medicine to stimulate ovulation. (NCI04)
C29774	Plutonium-239	Radioisotope	Plutonium-239|239PU|Pu-239	An artificial radioactive element with long half-life, Plutonium-239 is produced by bombarding uranium-238 with slow neutrons and is used as the explosive in nuclear weapons and as fuel for nuclear reactors. Similar to uranium, Plutonium-239 is a heavy, fissionable metal that accumulates in bones upon exposure and presents health hazards. Plutonium oxidation results in stable, easily inhaled, particulate plutonium dioxide that represents a respiratory health hazard. Plutonium ingestion is considerably less dangerous since little is absorbed in the digestive system. (NCI04)
C29775	Radium-224	Radioisotope	Radium-224|224Ra|Ra-224	A short-lived, alpha-emitting isotope found in ground water and soils, Radium-224 has been used in biomedical treatments. Radium-224 in drinking water is a potential health risk due to its carcinogenic effects. In the first days after intake, radium heavily concentrates in endosteal bone. Because of the 3.5-day half-life, most Ra-224 decays while on bone surfaces, possibly inducing sarcomas in cells within range of the emitted alpha particles. (NCI04)
C29776	Strontium-90	Radioisotope	Strontium-90|90Sr|Sr-90	A radioactive isotope of the heavy metal strontium, Strontium-90 is a by-product of uranium and plutonium fission. SR-90 is linked to bone, and other, cancers. Acting chemically in vivo like calcium, it tends to concentrate in bones and teeth. Used as a radioactive tracer in medical and agricultural studies, controlled amounts of strontium-90 have also been used as a treatment for bone cancer. (NCI04)
C29777	Uranium_Ore_Dust	Inorganic_Carcinogen	Uranium Ore Dust	Resulting from mining of radioactive heavy metal uranium, Uranium Ore Dust presents chemical and radiological hazards linked to inducing cancer. The major uranium isotope, U-238 has a long half-life while U-235 with shorter half-life emits gamma rays and alpha particles. Ore dust emits primarily alpha radioactivity; gamma radiation comes from associated radium and bismuth elements that result from radioactive uranium decay. During mining, toxic radon gas can also escape into the air and seep into surface water and groundwater. (NCI04)
C29778	Adenovirus_5-Fibroblast_Growth_Factor_2	Viral_Vector-Gene_Complex	Adenovirus 5-Fibroblast Growth Factor 2|Ad5-bFGF|Adenovirus Serotype 5 Expressing bFGF
C29779	_1-Nitrobenzo_a_pyrene	Polycyclic_Aromatic_Hydrocarbons	1-Nitrobenzo[a]pyrene|1-NBaP
C29780	_1-Nitrobenzo_a_pyrene_trans-7_8-Dihydrodiol	Benzo_a_pyrene_trans-7_8-Dihydrodiol	1-Nitrobenzo[a]pyrene trans-7,8-Dihydrodiol
C29781	_1-Nitropyrene	Nitroarene_Carcinogen	1-Nitropyrene|1-NP	A synthetic, light sensitive, yellow crystalline solid that is practically insoluble in water and soluble in diethyl ether, acetone, ethanol, benzene and toluene. It is not used for any commercial applications and is used only for research purposes, principally as a marker for exposure to nitro-polycyclic aromatic hydrocarbons from diesel exhaust. When heated to decomposition, 1-nitropyrene emits toxic fumes of nitrogen oxides. This compound is found in particulate emissions from combustion products, of which diesel exhaust is the principle source. The primary route of potential human exposure to 1-nitropyrene is inhalation. This compound is one of the most abundant mononitroarenes detected in ambient air. Occupational exposure to 1-nitropyrene occurs primarily in workers exposed to diesel engine exhaust in the transport industry. It is reasonably anticipated to be a human carcinogen. (NCI05)
C29782	_19-nor-Progesterone	Therapeutic_Progestin	19-nor-Progesterone	A steroid progestin derivative with antigonadotropic activity.  19-nor-Progesterone decreases luteinizing hormone (LH) and follicle stimulatory hormone (FSH) secretion, which are effects likely mediated through the binding of this agent to the progesterone receptor.  The antigonadotropic activity of this hormone results in reinforcement of its antiestrogenic activity, allowing treatment of the clinical hyper-estrogenic symptoms of peri-menopause without negative metabolic or hemostatic effects.  19-nor-Progesterone, in addition to its inhibitory effect on ovulation, induces changes in the endometrium, rendering it resistant to implantation, and in the cervical mucus, rendering it hostile to spermatozoa migration.  This agent is also a potent mineralocorticoid. (NCI04)
C29783	Androsterone	Therapeutic_Androgen	Androsterone	A steroid metabolite derived from sex hormones, which displays weak androgenic properties.  In testes is formed from progesterone.  Androsterone sulfate is clinically recognized as one of the major androgen metabolites found in urine, in males and females.  It is made in the liver from the metabolism of testosterone.  Androsterone glucuronide, a dihydrotestosterone metabolite, is present in serum.  Androsterone is a weak anabolic hormone. (NCI04)
C29784	Bovine_Pituitary_Extract	Biological_Agent	Bovine Pituitary Extract	A substance isolated from the pituitary glands of cattle which contains a variety of proteins, hormones, and growth factors.  Bovine pituitary extract is used in research as a mitogenic supplement in the cell culture of various epithelial and endothelial cell lines. (NCI04)
C29785	Recombinant_Adenovirus-Cre_Recombinase	Viral_Vector-Gene_Complex	Recombinant Adenovirus-Cre Recombinase
C29786	Recombinant_Adenovirus-LacZ	Viral_Vector-Gene_Complex	Recombinant Adenovirus-LacZ
C29787	_1_2-Dimethylhydrazine	Organo-nitrogen_Carcinogen	1,2-Dimethylhydrazine|DMH|Hydrazomethane	A compound used experimentally to induce tumors in animal models of carcinogenesis.  In mice and rats, 1,2-dimethylhydrazine may induce carcinogenesis through deregulation of the cell cycle. This agent primarily induces gastrointestinal and vascular tumors. 1,2-Dimethylhydrazine may be found in small amounts in the environment due to its use in industry and agriculture. (NCI04)
C29788	_1_2-Dimethylhydrazine_Dihydrochloride	Organo-nitrogen_Carcinogen	1,2-Dimethylhydrazine Dihydrochloride	The chloride salt of a compound used experimentally to induce tumors in animal models of carcinogenesis.  In mice and rats, 1,2-dimethylhydrazine may induce carcinogenesis through deregulation of the cell cycle. This agent primarily induces gastrointestinal and vascular tumors. 1,2-Dimethylhydrazine may be found in small amounts in the environment due to its use in industry and agriculture. (NCI04)
C29789	_1_2_5_6-Dibenzanthracene	Retired_Concepts	1,2,5,6-Dibenzanthracene
C29790	_1_3-Butadiene	Carcinogenic_Hydrocarbon	1,3-Butadiene|Vinylethylene	A synthetic, colorless gas that is practically insoluble in water and soluble in ethanol, ether, acetone and benzene. It is used primarily as a monomer to manufacture many different types of polymers and copolymers and as a chemical intermediate in the production of industrial chemicals. When heated, 1,3-butadiene emits acrid fumes and is flammable. In the presence of air, it oxidizes to form explosive peroxides. The primary route of potential human exposure to this compound is inhalation. Acute exposure to 1,3-butadiene can cause irritation of the eyes, nasal passages and throat. At very high concentrations, inhalation of this gas can result in headache, fatigue, decreased blood pressure and pulse rate, central nervous system damage and unconsciousness. It is known to be a human carcinogen. (NCI05)
C29791	_2-Acetylaminofluorene	Organo-nitrogen_Carcinogen	2-Acetylaminofluorene|2-AAF	A synthetic, light tan crystalline solid that is insoluble in water and soluble in alcohols, glycols, ether, acetic acid, and fat solvents. It is used as a positive control by toxicologists to study the carcinogenicity and mutagenicity of aromatic amines. When heated to decomposition, 2-acetylaminofluorene emits toxic fumes of nitrogen oxides. The primary routes of potential human exposure to 2-acetylaminofluorene are inhalation and dermal contact. It is reasonably anticipated to be a human carcinogen. (NCI05)
C29792	_2-Amino-1-Methyl-6-Phenylimidazo_4_5-b_pyridine	Heterocyclic_Amine_Carcinogen	2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine|PhIP	A synthetic, gray-white crystalline solid that is soluble in dimethylsulfoxide and methanol. It is produced in small quantities for research purposes. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine is formed naturally during the cooking of muscle-derived foods (meat and fish). Levels of this chemical produced in this manner are dependent on cooking temperature, cooking time and method of cooking (direct or indirect). It is one of the most abundant heterocyclic amines in a typical Western diet. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine has also been detected in processed food flavorings, beer, wine, and cigarette smoke. It is reasonably anticipated to be a human carcinogen. (NCI05)
C29793	_2-Amino-3_4-Dimethylimidazole_4_5-f_quinoline	Heterocyclic_Amine_Carcinogen	2-Amino-3,4-Dimethylimidazole[4,5-f]quinoline|MeIQ	A synthetic, yellow-green crystalline solid that is soluble in dimethylsulfoxide and methanol. It is produced in small quantities for research purposes. 2-Amino-3,4-dimethylimidazo[4,5-f]quinoline is formed naturally during the cooking of muscle-derived foods (meat and fish). Levels of this chemical produced in this manner are dependent on cooking temperature, cooking time and method of cooking (direct or indirect). 2-Amino-3-methylimidazo[4,5-f]quinoline has also been detected in processed food flavorings, beer, wine, and cigarette smoke. It is reasonably anticipated to be a human carcinogen. (NCI05)
C29794	_2-Fluoroadenine	Organo-halide_Carcinogen|Organo-nitrogen_Carcinogen	2-Fluoroadenine
C29795	_20-Methylcholanthrene	Polycyclic_Aromatic_Hydrocarbons	20-Methylcholanthrene|MCA
C29796	_2_6-Diaminopurine	Analog	2,6-Diaminopurine	One of a number of organic compounds that share a similar purine structure and possess antiviral and antitumor properties. 2,6-Diaminopurine nucleosides are versatile synthetic precursors for specific N-6 modifications of antiviral and antitumor agents. (NCI04)
C29797	_3-Aminobenzo_a_pyrene	Polycyclic_Aromatic_Hydrocarbons	3-Aminobenzo[a]pyrene|3-ABaP
C29798	_3-Nitrobenzo_a_pyrene	Polycyclic_Aromatic_Hydrocarbons	3-Nitrobenzo[a]pyrene|3-NBaP
C29799	_3-Nitrobenzo_a_pyrene_trans-7_8-Dihydrodiol	Benzo_a_pyrene_trans-7_8-Dihydrodiol	3-Nitrobenzo[a]pyrene trans-7,8-Dihydrodiol
C29800	_3_4-Benzpyrene	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon|Tobacco-Associated_Carcinogen	3,4-Benzpyrene|Benzo[a]pyrene|Benzo[d,e,f]chrysene	A crystalline, aromatic hydrocarbon consisting of five fused benzene rings and formed during the incomplete combustion of organic matter. 3,4-Benzpyrene is primarily found in gasoline and diesel exhaust, cigarette smoke, coal tar and coal tar pitch, charcoal-broiled foods and certain other foods, amino acids, fatty acids and carbohydrate pyrolysis products, soot smoke, creosote oil, petroleum asphalt and shale oils. This substance is used only for research purposes. 3,4-Benzpyrene is reasonably anticipated to be a human carcinogen. (NCI05)
C29801	_4-Methylnitrosamino_1-3-Pyridyl_1-Butanone	Carcinogenic_Nitrosamine	4-Methylnitrosamino-1,3-pyridyl-1-butanone|4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone|4-N-Nitrosomethylamino-1-3-Pyridyl-1-Butanone|NNK	A yellowish crystalline solid nitrosamine that naturally occurs in tobacco products by oxidation and nitrosation of nicotine during the making and smoking of tobacco. 4-Methylnitrosamino-1,3-pyridyl-1-butanone is only used as a research chemical to induce tumorigenesis. This substance is reasonably anticipated to be a human carcinogen. (NCI05)
C29802	_4-Nitroquinoline_N-oxide	Retired_Concepts	4-Nitroquinoline N-oxide
C29803	_4-o-Tolylazo-o-Toluidine	Retired_Concepts	4-o-Tolylazo-o-Toluidine
C29804	_5-Methylchrysene	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	5-Methylchrysene|5-MeC	A crystalline, carcinogenic aromatic hydrocarbon consisting of four fused rings and produced by the incomplete combustion of organic matter. 5-Methylchrysene is primarily found in gasoline exhaust and tobacco smoke. 5-Methylchrysene is reasonably anticipated to be a human carcinogen. (NCI05)
C29805	_6-Nitrochrysene	Nitroarene_Carcinogen	6-Nitrochrysene|6-NC	A synthetic solid appearing as chrome-red crystals or orange-yellow to light-yellow needles that is slightly soluble in acetic acid, cold ethanol, diethyl ether, benzene, and carbon disulfide, and soluble in hot nitrobenzene. It is not used for any commercial applications and is used only for research purposes, principally as an internal standard in the chemical analysis of nitroarenes. The primary route of potential human exposure to 6-nitrochrysene is inhalation. Low concentrations of this chemical have been found in ambient airborne particulates. It is reasonably anticipated to be a human carcinogen. (NCI05)
C29806	_9_10-Dimethyl-1_2-Benzanthracene	Retired_Concepts	9,10-Dimethyl-1,2-Benzanthracene
C29807	Acetone	Reagent	Acetone|2-Propanone|Dimethyl Formaldehyde|Methyl Ketone	A colorless, volatile, flammable organic solvent.  Acetone occurs naturally in plants, trees, forest fires, vehicle exhaust and as a breakdown product of animal fat metabolism.  This agent may be normally present in very small quantities in urine and blood; larger amounts may be found in the urine and blood of diabetics.  Acetone is toxic in high doses. (NCI04)
C29808	Benzo_a_pyrene	Retired_Concepts	Benzo[a]pyrene
C29809	Benzo_a_pyrene_trans-7_8-Dihydrodiol	Polycyclic_Aromatic_Hydrocarbons	Benzo[a]pyrene trans-7,8-Dihydrodiol
C29810	Benzo_b_fluoranthene	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	Benzo[b]fluoranthene|2,3-Benzfluoranthene|3,4-Benz(e)acephenanthrylene|3,4-Benzfluoranthene|B(b)F|Benzo(e)fluoranthene	A colorless, aromatic hydrocarbon consisting of five fused rings and formed by the incomplete burning of organic matter. Benzo(b)fluoranthene is primarily found in gasoline exhaust, tobacco and cigarette smoke, coal tar, soot, amino acids and fatty acid pyrolysis products. This substance is used only for research purposes. Benzo(b)fluoranthene is reasonably anticipated to be a human carcinogen. (NCI05)
C29811	Benzotrichloride	Carcinogenic_Chlorinated_Hydrocarbon	Benzotrichloride|BTC	An oily, unstable, colorless, chlorinated hydrocarbon with a penetrating odor. Benzotrichloride is used extensively as a chemical intermediate in industry for the preparation of dyes. Its derivatives are used as UV stabilizers in plastic and to manufacture antiseptics and antimicrobial agents. In the presence of moisture, its hydrolyzed vapors (benzoic acid and hydrochloric acid) are highly irritating to the skin and mucous membranes in humans. Benzotrichloride is reasonably anticipated to be a human carcinogen. (NCI05)
C29812	Beta-Naphthoflavone	Polycyclic_Aromatic_Hydrocarbons	Beta-Naphthoflavone|3-Phenyl-1H-naphtho[2,1-b]pyran-1-one|5,6-Benzoflavone|betaNF
C29813	Carbon_Disulfide	Organic_Chemical	Carbon Disulfide
C29814	Chlordane	Pesticide	Chlordane	Chlordane is a chlorinated hydrocarbon used as a non-systemic contact insecticide for lawns and crops. Actually a complex mixture of isomers, other chlorinated hydrocarbons, and by-products, chlordane is used in termite and ant control, and as a protective treatment for underground cables. Chlordane may be irritant and toxic by ingestion, inhalation, or skin absorption; toxic effects may be cumulative. When heated to decomposition, chlordane emits toxic fumes of carbon monoxide, hydrogen chloride, chlorine, and phosgene. Chlordane is very persistent in the environment, surviving in soils for more than 20 years. U.S. production of chlordane was stopped in 1976. (NCI04)
C29815	Chloroform	Carcinogenic_Chlorinated_Hydrocarbon|Reagent	Chloroform|Trichloromethane	A colorless, volatile, liquid derivative of trichloromethane with an ether-like odor.  Formerly used as an inhaled anesthetic during surgery, the primary use of chloroform today is in industry, where it is used as a solvent and in the production of the refrigerant freon.  Acute chloroform toxicity results in impaired liver function, cardiac arrhythmia, nausea and central nervous system dysfunction.  As a byproduct of water chlorination, chloroform may be present in small amounts in chlorinated water. (NCI04)
C29816	Crocidolite_Asbestos	Asbestos	Crocidolite Asbestos	A naturally occurring, blue, fibrous amphibole asbestos mineral. Crocidolite is used extensively in industry for various purposes. Chronic inhalation of its dust may cause asbestosis and increases the risk of respiratory tract cancer, mesothelioma and other lung cancers. Crocidolite asbestos is a known human carcinogen. (NCI05)
C29817	Croton_Oil	Organic_Carcinogen	Croton Oil	A yellow to brown colored, thick, foul smelling, very toxic oil obtained from the seeds of a tropical plant, Croton Tiglium. Croton oil was used as a drastic purgative agent, but is now mostly used as a standard irritant in pharmacological research. Exposure to this substance causes severe skin irritation and affects the small intestine leading to severe diarrhea. Croton oil is a possible human carcinogen. (NCI05)
C29818	Cyclopenta_cd_pyrene	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	Cyclopenta[cd]pyrene|Acepyrene|CPP	An aromatic hydrocarbon that consists of five fused rings and is formed during the incomplete combustion of organic matter. Cyclopenta[c,d]pyrene is primarily found in gasoline engine exhaust. This substance is used in laboratory research as a mutagen and carcinogen. Cyclopenta[c,d]pyrene is reasonably anticipated to be a human carcinogen. (NCI05)
C29819	Ether	Reagent	Ether|1,1'-Oxybisethane|Ethyl Ether	An organic compound in which two carbon atoms are linked through an oxygen atom (C-O-C).  An ether may be a product of the condensation of alcohols.  Ether also refers loosely to diethyl-ether, a colorless, volatile, highly inflammable liquid used in industry and biomedical research, and historically important as an anesthetic agent.  In vivo, ether acts similarly to alcohol and chloroform, but its stimulant action on the heart is much more marked.  Ether is a rapidly diffusible stimulant. (NCI04)
C29820	Ethyl_Methanesulfonate	Alkylating_Agent|Organic_Carcinogen	Ethyl Methanesulfonate	A sulfonoxyalkane with carcinogenic and teratogenic properties.  Ethyl methanesulfonate ethylates DNA, thereby damaging DNA and leading to genetic mutations, single-stranded breaks in DNA, and chromosomal aberrations.  Ethyl methanesulfonate may be used experimentally in biomedical research. (NCI04)
C29821	Ethylene_Oxide	Carcinogenic_Epoxide	Ethylene Oxide|1,2-Epoxyethane|Oxirane	Colorless, odorless, flammable, toxic gaseous cyclic ether with a sweet ether-like smell. Ethylene oxide is used especially in the synthesis of ethylene glycol and as a sterilizing agent for medical supplies and foods, as a fumigant and as an insecticide. Exposure to this substance is highly irritating to the eyes, skin and respiratory tract, induces nausea and vomiting and causes central nervous system depression. Ethylene oxide is mutagenic in humans and chronic exposure is associated with an increased risk of leukemia, stomach cancer, pancreatic cancer and non-Hodgkin's lymphoma. (NCI05)
C29822	Ferric-Nitrilotriacetate	Organic_Carcinogen	Ferric-Nitrilotriacetate|Fe-NTA
C29823	Hydroquinone	Organic_Carcinogen	Hydroquinone|1,4-Benzenediol|Benzoquinol|HYDROQUINONE	Produced as an inhibitor, an antioxidant, and an intermediate in the synthesis of dyes, motor fuels, and oils; in photographic processing; and naturally in certain plant species, Hydroquinone is a phenol derivative with antioxidant properties that can cause toxicity in several organs, notably the kidney. Used as a topical treatment for skin hyperpigmentation and in various cosmetic products, it is metabolized mainly to glutathione conjugates and forms mutagenic DNA adducts in in-vitro systems. (NCI04)
C29824	Isoprene	Carcinogenic_Hydrocarbon	Isoprene|2-Methyl-1,3-butadiene|Isopentadiene	An unsaturated pentahydrocarbon, Isoprene is found in certain plants or obtained by distillation of caoutchouc or gutta-percha. In plants, it is elementary in the formation of isoprenoids, fat-soluble vitamins, carotenoids and related pigments. Isoprennes contribute to flavors and fragrances of essential oils and other plant-derived substances. (NCI04)
C29825	N-Amyl-N-Methylnitrosoamine	Carcinogenic_Nitrosamine	N-Amyl-N-Methylnitrosoamine|AMN	A synthetic or natural carcinogenic compound found in a variety of smokes and industrial products, N-Amyl-N-Methylnitrosoamine is used in biomedical research to induce experimental hepatocarcinogenesis, probably through abnormal DNA methylation. (NCI04)
C29826	N-butyl-N-4-hydroxybutyl_nitrosamine	Carcinogenic_Nitrosamine	N-butyl-N-(4-hydroxybutyl)nitrosamine	A synthetic carcinogenic compound found in a variety of smokes and industrial products, N-butyl-N-4-hydroxybutyl nitrosamine is used in biomedical research to induce transitional and squamous cell urinary bladder cancers and to promote experimental hepatocarcinogenesis, probably through abnormal DNA methylation. (NCI04)
C29827	N-Nitrosodiethylamine	Carcinogenic_Nitrosamine	N-Nitrosodiethylamine|N,N-diethylnitrosamine|N-ethyl-N-nitroso-ethanamine|NDEA	A synthetic light-sensitive, volatile, clear yellow oil that is soluble in water, lipids, and other organic solvents.  It is used as gasoline and lubricant additive, antioxidant, and stabilizer for industry materials.  When heated to decomposition, N-nitrosodiethylamine emits toxic fumes of nitrogen oxides.  N-Nitrosodiethylamine affects DNA integrity, probably by alkylation, and is used in experimental research to induce liver tumorigenesis. It is considered to be reasonably anticipated to be a human carcinogen. (NCI05)
C29828	N-ethyl-N_nitro-N-nitrosoguanidine	Carcinogenic_Nitrosamine	N-ethyl-N'-nitro-N-nitrosoguanidine|ENNG	An alkyl nitrosoguanidine with carcinogenic properties.  Used to induce cancer in experimental animal models, N-ethyl-N'-nitro-N-nitrosoguanidine ethylates DNA, resulting in single- and double-stranded DNA breaks and the inhibition of DNA replication. (NCI04)
C29829	N-nitroso-N-methylurethane	Nitroso_Carcinogen	N-nitroso-N-methylurethane|N-Methyl-N-nitroso-ethylcarbamate	A synthetic organic agent, N-nitroso-N-methylurethane is carcinogenic in all species tested. Carcinogenic in single-dose experiments and following pre-natal exposure, it is used in experimental research to induce tumors at different sites by oral administration and other routes. N-nitroso-N-methylurethane has local as well as systemic carcinogenic effects. (NCI04)
C29830	Retinoblastoma_Binding_Protein-9	Transcription_Regulatory_Protein	Retinoblastoma Binding Protein 9|B5T Overexpressed Gene Protein|BOG Protein|RBBP10|RBBP9|Retinoblastoma-Binding Protein 10	Widely expressed as two alternative transcript variants by human RBBP9 Gene, 186-aa 21-kDa nuclear/cytoplasmic Retinoblastoma Binding Protein 9 confers resistance to TGF-Beta 1 growth inhibition through interaction with Rb and subsequent displacement of E2F-1 and may play a role in regulation of cell proliferation and differentiation. (NCI)
C29831	Retinoblastoma-Like-2_Protein	Cell_Cycle_Protein	Retinoblastoma-Like 2|130 kDa Retinoblastoma-Associated Protein|PRB2|RBL2|RBR2|Retinoblastoma-Like Protein 2|p130	Expressed only in G0 by human RBL2 Gene (RB Family), 1139-aa 128-kDa nuclear Retinoblastoma-Like 2 protein binds to adenovirus E1A protein and to cyclins A and E, associates preferentially with E2F5, inhibits E2F-mediated trans-activation, and may function in cell cycle regulation. Ser-672 phosphorylation in G1 leads to ubiquitin-dependent proteolysis of RBL2. (NCI)
C29832	RNA_Binding_Motif_Protein-5	RNA_Binding_Protein	RNA Binding Motif Protein 5|G15 Protein|Putative Tumor Suppressor LUCA15|RNA-Binding Protein 5	Widely expressed by human RBM5 Gene, 815-aa 92-kDa RNA Binding Motif Protein 5 contains 2 RRM domains, a G-patch domain, and a RANBP2-type zinc finger and specifically binds to RNA. (NCI)
C29833	RNA_Binding_Motif_Protein-6	RNA_Binding_Protein	RNA Binding Motif Protein 6|Lung Cancer Antigen NY-LU-12|Protein 3G2|Protein G16|RNA-Binding Protein 6|RNA-Binding Protein DEF3	Widely expressed by human RBM6 Gene, 1,123-aa RNA Binding Motif Protein 6 contains 20 inexact 6-aa N-terminal repeats, 2 RNA-binding domains, 2 zinc finger motifs, nuclear localization signals, and specifically binds RNA. (NCI)
C29834	RING_Box_Protein-1	Regulatory_Protein	RING Box Protein 1|RBX1|RING Finger Protein|RING Finger Protein 75|ROC1|Regulator of Cullins 1|ZYP Protein	Widely expressed by human RBX1 Gene (RING-Box Family), conserved cytoplasmic and nuclear 108-aa 12.3-kDa RING Box Protein 1, containing a RING-type zinc finger, mediates protein turnover of cell cycle, signal transduction, and transcription proteins by ubiquitination and proteasomal degradation. A component of various SCF, SCF-like, and CBC multisubunit E3 ubiquitin ligase complexes, RBX1 may recruit E2 enzymes to the complex through its RING-type zinc finger and heterodimerizes with cullins in the third step of ubiquitin conjugation reactions to catalyze ubiquitin polymerization. RBX1 promotes neddylation of CUL1 and probably CUL2. It also probably interacts with CDC34 and may stimulate CDC34 autoubiquitination. (NCI)
C29835	Reticulocalbin-2	Calcium_Binding_Protein	Reticulocalbin 2|Calcium-Binding Protein ERC55|E6-Binding Protein|E6BP|Endoplasmic Reticulum Calcium-Binding Protein 55kD|RCN2	Encoded by human RCN2 Gene (CREC Family), ubiquitous 317-aa 55-kD calcium-binding Reticulocalbin 2 contains 6 conserved helix-loop-helix EF-hand calcium-binding domains and a C-terminal HDEL sequence required for ER retention. RCN2 appears to interact with human papillomavirus transforming protein E6 and with the vitamin D receptor. (NCI)
C29836	DNA_Topology_Regulation	DNA_Modification_Process	DNA Topology Regulation	DNA Topology Regulation involves DNA topoisomerases that catalyze essential DNA transaction processes, including DNA strand scission, manipulation, and rejoining, in order to attain a balanced topology of the genome. Contrasting activities of DNA topoisomerase I and DNA gyrase result in the maintenance of DNA topological homeostasis. (NCI)
C29837	RET_Finger_Protein	Transcription_Regulatory_Protein	RET Finger Protein|RFP|Tripartite Motif Protein 27|Tripartite Motif Protein TRIM27|Zinc-Finger Protein RFP	Encoded by human RFP Gene (TRIM Family), 513-aa 58.5-kDa RET Finger Protein contains a TRIM motif: 3 zinc-binding domains, a RING, a type 1 and type 2 B-box, and a coiled-coil region. Located in the nuclear matrix, RFP interacts with enhancer of polycomb protein, represses gene transcription, and is thought to be involved in male germ cell differentiation. Gene rearrangements with RET produce RET transforming protein, containing the RFP N-terminus with the RET protein tyrosine kinase. (NCI)
C29838	RET_Finger_Protein-2	Protein_with_Unknown_or_Unclassified_Function	RET Finger Protein 2|B-Cell Chronic Lymphocytic Leukemia Tumor Suppressor LEU5|CLL-Associated RING Finger|Leukemia Associated Protein 5|Putative Tumor Suppressor RFP2|Tripartite Motif Protein 13	Encoded by human RFP2 Gene (TRIM Family), 407-aa 47-kDa RET Finger Protein 2, of unknown function, is localized to cytoplasmic bodies near the nucleus and contains a TRIM motif: 3 zinc-binding domains, a RING, type 1 and type 2 B-boxes, and a coiled-coil region. RFP2 may act as a tumor suppressor and may be involved in 13q14 deletion B-CLL. (NCI)
C29839	Naphthalene	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	Naphthalene|Naphthene	A white, volatile, solid polycyclic hydrocarbon with a strong mothball odor. Naphthalene is obtained from either coal tar or petroleum distillation and is primarily used to manufacture phthalic anhydride, but is also used in moth repellents. Exposure to naphthalene is associated with hemolytic anemia, damage to the liver and neurological system, cataracts and retinal hemorrhage. Naphthalene is reasonably anticipated to be a human carcinogen and may be associated with an increased risk of developing laryngeal and colorectal cancer. (NCI05)
C29840	Nicardipine	Calcium_Channel_Blocker	Nicardipine Hydrochloride|NICARDIPINE HYDROCHLORIDE|Nicardipine	A synthetic derivative of nitrophenyl-pyridine and potent calcium channel blocker, Nicardipine (Nifedipine Family) blocks calcium ions from certain cell walls and inhibits contraction of coronary and peripheral arteries, resulting in lowered oxygen requirements for heart muscle and decreased arterial contraction and spasm. It is used clinically as a cerebral and coronary vasodilator. (NCI04)
C29841	Nickel_Subsulfide	Environmental_Carcinogen	Nickel Subsulfide	Exposure to inorganic carcinogenic Nickel Subsulfide, an atmospheric pollutant primarily generated by industries that manufacture lithium batteries, results in inflammation, hyperplasia, and fibrosis in the lungs and olfactory epithelium. (NCI04)
C29842	Nimesulide	Cyclooxygenase_Inhibitor	Nimesulide|N-(4-Nitro-2-phenoxyphenyl)methanesulfonamide	A nonsteroidal arylsulfonamide with anti-inflammatory properties.  Nimesulide inhibits the cyclooxygenase-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins.  Modestly selective for COX-2, this agent binds to the enzyme, thereby inactivating it.  Nimesulide may inhibit some carcinogenic COX-2-related carcinogenic effects on xenobiotic metabolism, apoptosis, immune surveillance and angiogenesis (overexpressed COX-2 in tumor epithelial cells enhances production of vascular growth factors and the formation of capillary-like networks). (NCI04)
C29843	Nitrogen_Dioxide	Inorganic_Chemical	Nitrogen Dioxide	Found in the atmosphere as a key ingredient in photochemical formation of smog and acid rain, Nitrogen Dioxide is a poisonous gas that forms during combustion. Toxic at high concentrations, it reacts with moisture in the air to form nitric acid, highly corrosive and hazardous to plants and animals. (NCI04)
C29844	Week	Temporal_Modifier	Week|Weeks	Any period of seven consecutive days.
C29845	o-Aminoazotoluene	Carcinogenic_Aromatic_Amine	o-Aminoazotoluene|4-o-Tolylazo-o-Toluidine	A synthetic organic azo dye used mainly in experimental research, carcinogenic o-Aminoazotoluene induces hepatomas, lung tumors, bladder tumors, and lung hemangioendotheliomas in animals when administered in the diet. (NCI04)
C29846	Month	Temporal_Modifier	Month|Months	One of the 12 divisions of a year as determined by a calendar.  It corresponds to the unit of time of approximately to one cycle of the moon's phases, about 30 days or 4 weeks.
C29847	Cresidine	Carcinogenic_Aromatic_Amine	Cresidine|2-Methoxy-5-Methyl-Benzenamine|2-Methoxy-5-Methylaniline|3-Amino-4-Methoxytoluene|4-Methyl-2-Aminoanisole|Azoic Red 36|p-Cresidine	A white, crystalline aromatic amine that is soluble in organic solvents and emits toxic fumes of nitrogen oxides when heated to decomposition. p-Cresidine is exclusively used as a chemical intermediate in the manufacture of dyes. p-Cresidine is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C29848	Year	Temporal_Modifier	Year|Years	The period of time that it takes for Earth to make a complete revolution around the sun, approximately 365 days; a specific one year period.
C29849	Piperonyl_Butoxide	Cyclic_Ether_Carcinogen	Piperonyl Butoxide|5-[[2-(2-Butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole|Alpha-[2-(2-butoxyethoxy)ethoxy-4,5-Methylenedioxy-2-Propyltoluene|NCI CO28l3|PBO|PIPERONYL BUTOXIDE	A synthetic derivative of benzodioxole and used as an insecticide synergist, Piperonyl Butoxide enhances the active properties of pyrethrin, pyrethroid, rotenone, and carbamate pesticide ingredients by inhibiting insect microsomal enzyme detoxification activity. It is toxic and suspected of causing anorexia, carcinogenesis, convulsions, and dermal irritation, as well as hepatic and renal damage. (NCI04)
C29850	Pristane	Carcinogenic_Hydrocarbon	Pristane|2,6,10,14-Tetramethylpentadecane	A natural or synthetic isoprenoid hydrocarbon (C19) derivative, Pristane is commonly used in research to prime the abdomen prior to hybridoma implantation in experimental animals. An irritant that induces granulomatous inflammation and interferes with local lymphatic drainage, it increases ascitic yields. Pristane has a low margin of safety and is toxic at levels slightly higher than used to prime animals. (NCI04)
C29851	Off_Study	General_Modifier	Off Study|Off Protocol|Off-Protocol|Off-Study	No longer participating in a study; not being followed and will not be retreated.
C29852	Rebamipide	Anti-ulcer_Agent	Rebamipide|alpha-[(4-Chlorobenzoyl)amino]-1,2-dihydro-2-oxo-4-quinolinepropanoic Acid
C29853	Silica	Carcinogenic_Mineral	Silica	A natural compound of silicon and oxygen found mostly in sand, Silica has three main crystalline varieties: quartz, tridymite, and cristobalite. Fine particulate silica dust from quartz rock causes over a long-term progressive lung injury, silicosis. (NCI04)
C29854	Sulindac_Sulfide	Cyclooxygenase_Inhibitor	Sulindac Sulfide|(1Z)-5-Fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic Acid	The active metabolite of sulindac, a sulfinylindene derivative with anti-inflammatory, analgesic and antipyretic properties.  Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) which inhibits cyclooxygenase (COX-1 and-2)-mediated conversion of arachidonic acid to pro-inflammatory prostaglandins.  This agent may possess chemopreventive activity against colorectal tumors through a mechanism that involves the induction of apoptosis.  The sulfide metabolite is excreted in the bile and reabsorbed from the intestine, thereby helping to maintain constant blood levels and reduce gastrointestinal side effects. (NCI04)
C29855	Theaflavins	Antioxidant	Theaflavins|Theaflavin	A class of natural flavonoids derived from the dried leaves of the plant Camellia sinensis (tea) and related plants with potent antioxidant properties.  Theaflavins are polymers derived from natural catechins which are oxidized upon drying of the plant leaf.  Flavonoids such as theaflavins neutralize free-radical species and increase the activity of detoxifying phase II enzymes in the liver.  In animal studies, theaflavins have been shown to exhibit antitumor effects by inducing tumor cell apoptosis, arresting cell division, inhibiting cancer cell invasion, and blocking growth factor-induced angiogenesis.  Black tea contains the highest concentrations of theaflavins. (NCI04)
C29856	Thiouracil	Nitric_Oxide_Synthetase_Inhibitor	Thiouracil	A sulfur-containing uracil.  An established antithyroid drug and highly selective inhibitor of nitric oxide synthase (NOS), thiouracil also covalently binds to dopaquinone, produced by tyrosinase catalyzed oxidation of tyrosine, thereby selectively accumulating in de novo-synthesized melanin in overactive melanin-producing cells and providing a means to localize melanoma cells. (NCI04)
C29857	Translational_Regulation	Gene_Regulation	Translational Regulation	The control of gene expression at the level of protein translation.
C29858	Triethylenemelamine	Ethylenimine_Compound	Triethylenemelamine|TEM|Triethylene Melamine	A trisaziridine alkylating agent with antineoplastic and carcinogenic properties.  Used to induce cancer in experimental animal models, triethylenemelamine ethylates DNA, resulting in inhibition of DNA replication, unscheduled DNA synthesis, chromosomal aberrations, and sister chromatid exchanges.  This agent also exhibits reproductive toxicities. (NCI04)
C29859	Translational_Activation	Translational_Regulation	Translational Activation	Translational Activation consists of cellular and enzymatic reactions that promote the process by which polypeptides are synthesized on ribosomes from information in mRNA transcripts.
C29860	Translational_Repression	Translational_Regulation	Translational Repression|Translational Inhibition	Translational Repression consists of cellular and enzymatic reactions that inhibit the process by which polypeptides are synthesized on ribosomes from information in mRNA transcripts.
C29861	Tricaprylin	Drug_Vehicle	Tricaprylin|Glycerol Tricaprylate|Octanoic Acid, 1,2,3-Propanetriyl Ester
C29862	Process	Conceptual_Entities	Process	A sequence of events which produces some outcome.
C29863	Triphenylethylene	Aromatic_Hydrocarbon	Triphenylethylene	the core chemical structure of a number of related anti-estrogen compounds. The triphenylethylene antiestrogens, which include idoxifene, toremifene, chlorotrianisene, raloxifene and tamoxifen, act at the level of the estrogen receptor, triggering inhibition or stimulation of estrogen-dependent gene transcription and cellular physiology.  Triphenylethylenes were initially developed for the treatment of estrogen-dependent breast cancers.  Selective estrogen receptor modulators (SERMs) such as raloxifene and tamoxifen represent triphenylethylene derivatives that affect transcriptional regulation through modulation of specific alpha and beta estrogen receptors that are differentially expressed in various normal and neoplastic tissues. (NCI04)
C29864	Vinyl_Carbamate	Organic_Carcinogen	Vinyl Carbamate	A synthetic organic compound produced in industry, Vinyl Carbamate is used in biomedical research to induce experimental (especially skin and lung) tumors in animals. Metabolism of Vinyl Carbamate leads to formation of electrophilic reactants that covalently bind to macromolecules (DNA-, RNA-, and protein-adducts) and initiate carcinogenesis. (NCI04)
C29865	Zinc_Chloride	Astringent	Zinc Chloride|ZINC CHLORIDE|ZnCl2
C29866	Pirinixic_Acid	Organic_Carcinogen	Pirinixic Acid|WY-14,643	A synthetic thiacetic acid derivative used in biomedical research, carcinogenic Pirinixic acid is a peroxisome proliferator that activates specific peroxisome proliferator-activated receptors (PPAR). PPARs play an important role in diverse cellular functions, including lipid metabolism, cell proliferation, differentiation, adipogenesis, and inflammatory signaling. (NCI04)
C29867	Participant	Population_Group	Participant	Someone who takes part in an activity.
C29868	Rhodopsin_Kinase	Regulatory_Protein	Rhodopsin Kinase|G Protein-Coupled Receptor Kinase 1B|GRK1|RHOK|RK	Encoded by human RHOK Gene (GPRK Family), 563-aa 64-kDa membrane-bound Rhodopsin Kinase, containing 1 RGS domain, regulates GPCR rhodopsin desensitization and initiates rhodopsin deactivation by phosphorylation following light stimulation. (NCI)
C29869	sn-1_2-Didecanoylglycerol	Tumor_Promoter	sn-1,2-Didecanoylglycerol|DiC10	A synthetic lipid second messenger.  As an analog of the second messenger diacylglycerol, sn-1,2-didecanoylglycerol substitutes for diacylglycerol in the cascade of calcium and phospholipid dependent PKC activation.  Topical application of this agent results in a striking inflammatory response characterized by edema, extensive epidermal infiltration of neutrophils and macrophages, intraepidermal microabscesses. sn-1,2-Didecanoylglycerol is used as a tumor promoter in experimental animal models of skin cancer due to its stimulation of epidermal protein kinase C activity. (NCI04)
C29870	LIM_Domain_Protein	Protein_with_Unknown_or_Unclassified_Function	LIM Domain Protein|Enigma Homolog|LIM Protein RIL|PDLIM4|Reversion-Induced LIM Protein	Encoded by human RIL Gene, 330-aa 35-kDa LIM Domain Protein contains a LIM zinc-binding domain and a PDZ/DHR domain. (NCI)
C29871	Black_Tea	Nutritional_Supplement	Black Tea|Tea, Black Extract	Black Tea is an infusion of dried leaves from plants of the Theaceae family. Due to the alkaloid caffeine, its main effect is stimulation. Black teas also contain other phytochemicals such as flavonoid and flavonoid-related compounds with strong antioxidant effects. They also attenuate atherosclerotic inflammation, reduce thrombosis, promote normal endothelial function, and block expression of cellular adhesion molecules. Black tea may reduce the risk of cancer, heart diseases, infectious diseases, and degenerative diseases. (NCI04)
C29872	Receptor-Interacting_Serine-Threonine_Protein_Kinase-2	Signaling_Protein	Receptor-Interacting Serine/Threonine Protein Kinase 2|CARD-Containing IL-1 Beta Ice-Kinase|CARD-Containing Interleukin-1 Beta Converting Enzyme Associated Kinase|RIP-Like Interacting CLARP Kinase|RIP2|RIPK2|Receptor Interacting Protein 2|Receptor-Interacting Protein 2	Expressed in heart, brain, placenta, lung, peripheral leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node by RIPK2 Gene (Ser/Thr Kinase Family), autophosphorylated. 540-aa 61-kDa cytoplasmic Receptor-Interacting Serine/Threonine Kinase 2, containing 1 CARD domain, activates NF-Kappa B and potentiates apoptosis by activating pro-caspase-1 and pro-caspase-8. RIPK2 binds to BIRC3/c-IAP1, BIRC2/c-IAP2, TRAF1, TRAF2, TRAF5, and TRAF6 and binds to CFLAR/CLARP and CASP1 via their CARD domains. RIPK2 may be a component of the TNFRSF1A and TNRFSF5/CD40 receptor complexes. (NCI)
C29873	Receptor-Interacting_Serine-Threonine_Protein_Kinase-3	Signaling_Protein	Receptor-Interacting Serine/Threonine Protein Kinase 3|RIP-Like Protein Kinase 3|RIP3|RIPK3|Receptor-Interacting Protein 3	Expressed in heart, brain, placenta, skeletal muscle, kidney, pancreas, spleen, lung, peripheral blood leukocytes, prostate, testis, and colon by human RIPK3 Gene (Ser/Thr Kinase Family), autophosphorylated (Lys50) cytoplasmic 518-aa 57-kDa Receptor-Interacting Serine/Threonine Kinase 3 contains a distinct C terminus that interacts with RIPK1and an N-terminal kinase domain similar to RIPK1 and RIPK2. RIPK3 also colocalizes in the mitochondrion with RIPK1. RIPK3 is recruited to the TNFR1 complex in a RIPK1-dependent manner and interacts with TRAF2. The RIPK3 C terminus is required to induce apoptosis through the activation of some or all caspases and also appears to activate NFKB. RIPK3 can stimulate NFKB nuclear translocation. (NCI)
C29874	Ring_Finger_Protein-11	Protein_with_Unknown_or_Unclassified_Function	Ring Finger Protein 11|CGI123|RNF11|SID1669	Encoded by human RNF11 Gene, 154-aa 17-kDa Ring Finger Protein 11 contains a RING-H2 zinc finger motif important for protein-protein interactions. RNF11 may interact with NEDD4. RNF11 expression is induced by mutant RET proteins (MEN2A/MEN2B).  (NCI)
C29875	Ribosomal_RNA-1	Ribosomal_RNA	RNA, Ribosomal 1|RNR1|Ribosomal RNA-1	Encoded by human RNR1 Gene, RNA Ribosomal 1 is a ribosomal RNA associated with proteins as structural components of a ribosome where polypeptides are produced by interacting with tRNA and mRNA. (From NCI)
C29876	Ribonuclease-III	Regulatory_Protein	Ribonuclease III|DROSHA|Nuclear RNase III Drosha|RN3|RNASE3L|RNase III|p241	Encoded as 2 alternative isoforms by human RNase III Gene, ubiquitous 1374-aa 159-kDa nuclear Ribonuclease III contains a DRBM domain and 2 RNase III domains. Involved in pre-rRNA processing, RNase III endonucleolytically cleaves double-strand, not single-strand, RNA to 5'-phosphomonoester. RNase III interacts with Sp1 and a fraction is translocated to the nucleolus during S phase. (NCI)
C29877	ROCK1_Protein	Signaling_Protein	Rho-Associated, Coiled-Coil Containing Protein Kinase 1|ROCK1|p160ROCK	Encoded by human ROCK1 Gene, Rho-Associated Coiled-Coil Containing Protein Kinase 1 is a Ser/Thr kinase activated when bound to GTP-bound Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between inactive GDP-bound and active GTP-bound forms. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. As a downstream effector of Rho, ROCK phosphorylates and activates LIM kinase, which phosphorylates cofilin and inhibits its actin-depolymerizing activity. (NCI)
C29878	Family_Cancer_History	Family_Medical_History	Family Cancer History	A record of a patient's medical background regarding the cancer and cancer-related problems of blood relatives.  (NCI)
C29879	Receptor_Tyrosine_Kinase-Like_Orphan_Receptor-1	Receptor_Tyrosine_Kinase	Receptor Tyrosine Kinase-Like Orphan Receptor 1|NTRKR1|Neurotrophic Tyrosine Kinase Receptor-Related 1|ROR1|Tyrosine-Protein Kinase Transmembrane Receptor ROR1	Expressed in heart, lung, kidney, and CNS as 2 alternative isoforms by human ROR1 Gene (ROR/Tyr Kinase Family), 937-aa 10-kDa (precursor) type I membrane protein Receptor Tyrosine Kinase-Like Orphan Receptor 1 is a receptor protein tyrosine kinase containing a FZ domain, 1 Ig-like C2-type domain, and 1 kringle domain whose cellular function has not been determined. ROR1 may interact with another receptor protein tyrosine kinase and be involved in skeletal and cardiac development. (NCI)
C29880	Receptor_Tyrosine_Kinase-Like_Orphan_Receptor-2	Receptor_Tyrosine_Kinase	Receptor Tyrosine Kinase-Like Orphan Receptor 2|BDB|BDB1|NTRKR2|Neurotrophic Tyrosine Kinase Receptor-Related 2|ROR2|Tyrosine-Protein Kinase Transmembrane Receptor ROR2	Expressed during early embryonic development and only at low levels in adult tissues by human ROR2 Gene (ROR/Tyr Kinase Family), 943-aa 105-kDa (precursor) Receptor Tyrosine Kinase-Like Orphan Receptor 2 is a type I transmembrane receptor protein tyrosine kinase containing a FZ domain, an Ig-like C2-type domain, and a kringle domain that may be involved in early formation of chondrocytes and cartilage development. (NCI)
C29881	RAR-Related_Orphan_Receptor-A	Nuclear_Orphan_Receptor	RAR-Related Orphan Receptor A|NR1F1|Nuclear Receptor ROR-Alpha|Nuclear Receptor RZR-Alpha|RAR-Related Orphan Receptor Alpha|ROR-Alpha|RORA|RZRA|Retinoic Acid Receptor-Related Orphan Receptor Alpha|Transcription Factor RZR-Alpha	Encoded by human RORA Gene (NR1 Family) as 4 alternative isoforms, monomeric or homodimeric 556-aa 63-kDa nuclear RAR-Related Orphan Receptor A is an orphan hormone receptor that binds to genomic DNA regulatory elements of hormone-responsive genes containing a single core motif half-site preceded by a short A-T-rich sequence. RORA interacts with nucleoside diphosphate kinase NM23-2, involved in organogenesis and differentiation, as well as with metastasis suppressor NM23-1 gene product. (NCI)
C29882	Ribosomal_Protein-L10	Ribosomal_Protein	Ribosomal Protein L10|60S Ribosomal Protein L10|Laminin Receptor Homolog|QM Protein|RPL10|Tumor Suppressor QM|Wilms Tumor-Related Protein	Encoded by human RPL10 Gene (L10E Family), down-regulated during adipocyte, kidney, and heart differentiation, 213-aa 24-kDa cytoplasmic Ribosomal Protein L10 is a component of the ribosomal 60S subunit. Ribosomes catalyze protein synthesis and consist of 40S and 60S subunits composed of 4 rRNAs and approximately 80 structurally distinct proteins. RPL10 may also bind to and repress c-Jun transcriptional activation. (NCI)
C29883	AS101	Immunostimulant	AS101|AS-101
C29884	Vaccinia_Virus_Study	Clinical_Study	Vaccinia Virus Study	Clinical Vaccinia Virus Studies employ vaccinia virus as an attenuated agent or as a vector for gene transfer. In attenuated form, Vaccinia virus can be used for protection against smallpox virus (variola) and is a highly effective immunizing agent. When genetically altered to contain human genes, Vaccinia virus can be used in cancer immunotherapy to induce immune protection against some forms of cancers. (NCI04)
C29885	Cholesterol_Homeostasis	Lipid_Metabolism	Cholesterol Homeostasis	Any of the processes involved in the maintenance of an internal equilibrium of cholesterol within an organism or cell. (Gene Ontology)
C29886	Airborne_Particulate_Matter	Pollutant	Airborne Particulate Matter|APM	Airborne Particulate Matter is a broad class of materials and substances of minute size present in the air that originate from industrial manufacturing processes, automobile exhaust, forest fires, and fossil fuel combustion. Scientific studies have shown that airborne particles are associated with adverse health effects inducing respiratory diseases, heart ailments, and other problems. When inhaled, these particles are likely to reach deeply into the lungs. The Environmental Protection Agency (EPA) sets standards to control the emission of these particulates and to protect the public health. (NCI04)
C29887	Californium-252_Fission_Neutron_Radiation	Alpha_Radiation	Californium-252 Fission Neutron Radiation|Cf-252	Californium-252 is a neutron emitter with a high specific activity.  It is used most often in brachytherapy for cancer patients.
C29888	Mumps	Viral_Infection	Mumps|Epidemic Parotitis|Parotitis
C29889	Regressing_Friend_Leukemia_Virus	Mouse_Leukemia_Virus	Regressing Friend Leukemia Virus|CFV|Friend Leukemia Virus, Regressing|Regressing FV	Animals inoculated with the regressing strain of Friend virus exhibited an initial pathologic response identical to that induced by conventional strains of Friend virus. Unlike the fatal leukemia produced by conventional Friend virus, the pathology of the disease induced by the regressing strain of Friend virus regresses in 50% of leukemic mice.
C29890	Gastrectomy_with_Esophagojejunostomy	Gastrectomy	Gastrectomy with Esophagojejunostomy
C29891	Muscle_Relaxant_Preparation	Combination_Medication	Muscle Relaxant Preparation
C29892	Unilateral_Oophorectomy	Oophorectomy	Unilateral Oophorectomy|Unilateral Ovariectomy|ovariectomy - unilateral	Surgery to remove one ovary.
C29893	Incomplete_Oophorectomy	Oophorectomy	Incomplete Oophorectomy|Incomplete Ovariectomy|Ovariectomy, Incomplete	Surgery that does not remove the entire ovary.  This can be by design or by error.
C29894	Thymectomy	Surgical_Procedure	Thymectomy	An operation to remove the thymus gland.
C29895	Inhibition_of_Cancer_Cell_Growth	Cancer_Cell_Growth_Regulation	Inhibition of Cancer Cell Growth	Inhibition of Cancer Cell Growth involves intercellular, cellular, and subcellular mechanisms that inhibit or block the induction, promotion, maintenance, or completion cell division in cancer cells.
C29896	Stimulation_of_Cancer_Cell_Growth	Cancer_Cell_Growth_Regulation	Stimulation of Cancer Cell Growth	Stimulation of Cancer Cell Growth involves intercellular, cellular, and subcellular mechanisms that induce, promote, sustain, or ensure cell division in cancer cells.
C29897	Ovarian_Implantation	Organism_Modification	Ovarian Implantation
C29898	Pituitary_Isograft	Organism_Modification	Pituitary Isograft	Grafting of pituitary tissue between genetically identical individuals; synonym for isogenic (pituitary) graft.(NCI2005)
C29899	Male_Gonadal_Ridge_Implantation	Organism_Modification	Male Gonadal Ridge Implantation	A technique for transplantation of stem cells, derived from embryonic gonadal ridge (embryonic germ cells), which are pluripotent and capable of self-renewal for long periods. The technique has a wide potential to cure diseases by repairing or replacing damaged cells and tissues as well as in gene therapy. (NCI2005)
C29900	Mechanical_Stimulation	Organism_Modification	Mechanical Stimulation
C29901	Moloney_Murine_Leukemia_Virus_TB	Moloney_Leukemia_Virus	Moloney Murine Leukemia Virus TB|MoMuLV-TB|Moloney Murine Leukemia Virus, TB Strain
C29902	Nodule-Inducing_Virus	Mouse_Mammary_Tumor_Virus	Nodule-Inducing Virus|NIV	An exogenous, infectious mouse mammary tumor virus isolated from BALB/cNIV/Crgl mice, thought to be derived from the endogenous low oncogenic mouse mammary tumor virus found in C3Hf mice. (from Cancer Res. 1984 Oct;44(10):4333-6)
C29903	Ribosomal_Protein-L7A	Ribosomal_Protein	Ribosomal Protein L7a|60S Ribosomal Protein L7a|PLA-X Polypeptide|RPL7A|SURF3|Surfeit 3|Surfeit Locus Protein 3|TRUP|Thyroid Hormone Receptor Uncoupling Protein	Encoded by human RPL7A Gene (L7AE Family), 265-aa 30-kDa Ribosomal Protein L7a is a component of the large 60S ribosomal subunit. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. RPL7A can inhibit a subclass of transactivating nuclear hormone receptors, including THR, by preventing DNA binding. Gene rearrangements with TRK form TRK-2H, which encodes an oncoprotein of the RPL7A N terminus fused to the TRK tyrosine kinase domain. (NCI)
C29904	Ribosomal_Protein-S19	Ribosomal_Protein	Ribosomal Protein S19|40S Ribosomal Protein S19|RPS19	Encoded by human RPS19 Gene (S19E Family), 144-aa 16-kDa cytoplasmic Ribosomal Protein S19 is a component of the 40S ribosomal subunit. S19 lacks cysteine residues and has a possible function in erythropoietic differentiation and proliferation. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. (NCI)
C29905	Ribosomal_Protein-S27	Ribosomal_Protein	Ribosomal Protein S27|40s Ribosomal Protein S27|MPS-1|Metallopan-Stimulin 1|Metallopanstimulin 1|RPS27	Expressed in actively proliferating cells by human RPS27 Gene (S27E Family), 83-aa 9-kDa Ribosomal Protein S27 is located in the cytoplasm as a component of the 40S ribosomal subunit, but is also detected in the nucleus. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. S27 appears to be located near ribosomal protein S18 and to be covalently linked to translation initiation factor eIF3. S27 contains a C4-type zinc finger domain and is able to bind to nucleic acid. (NCI)
C29906	Ribosomal_Protein-S3	Ribosomal_Protein	Ribosomal Protein S3|40S Ribosomal Protein S3|RPS3	Encoded by human RPS3 Gene (S3P Family), cytoplasmic and nuclear 243-aa 27-kDa Ribosomal Protein S3 contains a KH type-2 domain and is a component of the 40S ribosomal subunit as part of the translation initiation domain. Composed of small 40S and large 60S subunits containing 4 rRNAs and approximately 80 proteins, ribosomes catalyze protein synthesis. RPS3 also appears to be an endonuclease involved in UV-induced DNA repair. (NCI)
C29907	Murine_Retrovirus_Containing_Human_PDGFB_cDNA	Viral_Vector-Gene_Complex	Murine Retrovirus Containing Human PDGFB cDNA	A murine retrovirus that contains plasmid DNA (cDNA) coding for the B chain of platelet-derived growth factor (PDGFB).  Overexpressed in some human brain tumors, PDGFB and PDGF receptors may stimulate tumor development in an autocrine manner.  A murine retrovirus containing human PDGFB cDNA may be used to induce brain tumors in animal models of brain tumorigenesis. (NCI04)
C29908	RCAS-Akt	Viral_Vector-Gene_Complex	RCAS-Akt	A gene-vector complex composed of a retroviral vector derived from the SR-A strain of Rous sarcoma virus and carrying a constitutively active form of the AKT Gene. The name RCAS stands for Replication-Competent ASLV long terminal repeat (LTR) with a Splice acceptor.
C29909	Ribosomal_Protein-S6_Kinase_Alpha-5	Signaling_Protein	Ribosomal Protein S6 Kinase Alpha 5|90 kDa Ribosomal Protein S6 Kinase 5|Mitogen- and Stress-Activated Protein Kinase 1|Nuclear Mitogen-and Stress-Activated Protein Kinase-1|RLSK|RPS6KA5|RSK-Like Protein Kinase|Ribosomal Protein S6 Kinase 90kD Polypeptide 5	Widely expressed in heart, brain, placenta, lung, kidney, and liver by human RPS6KA5 Gene (S6 Ser/Thr Kinase Family), predominantly nuclear 802-aa 90-kDa Ribosomal Protein S6 Kinase Alpha 5 is a Ser/Thr kinase that associates with, phosphorylates, and controls NF-Kappa-B p65 subunit (RELA) transcriptional activity in response to TNF. RPS6KA5 activity requires the presence of both kinase domains. Likely activated by ERK1/2 and p38 Ser/Thr phosphorylations, RPS6KA5 transiently dissociates from complexes with ERK1/2 following mitogenic stimulation and may mediate growth factor and stress induced activation of transcription factor CREB. RPS6KA5 also associates with MAPK14/p38alpha. (NCI)
C29910	RCAS-Ras	Viral_Vector-Gene_Complex	RCAS-Ras	A gene-vector complex composed of the RCAS retroviral vector derived from the SR-A strain of Rous sarcoma virus and encoding the G12D mutant form of K-Ras. The name RCAS stands for Replication-Competent ASLV long terminal repeat (LTR) with a Splice acceptor.
C29911	Ribosomal_Protein_S6_Kinase_Beta-2	Protein_Kinase	Ribosomal Protein S6 Kinase Beta 2|70 kDa Ribosomal Protein S6 Kinase 2|RPS6KB2|Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2|S6 Kinase-Related Kinase|S6K-Beta 2|S6K2|SRK|Serine/Threonine-Protein Kinase 14 Beta|p70 Ribosomal S6 Kinase Beta|p70 S6K Beta|p70-Beta|p70-S6KB|p70S6KB	Encoded by human RPS6KB2 Gene (S6 Ser/Thr Kinase Family), 482-aa 53-kDa Ribosomal Protein S6 Kinase Beta 2 specifically phosphorylates 40S ribosomal protein S6, the major eukaryotic ribosome substrate of many kinases. S6 phosphorylation is stimulated by growth factors and mitogens; dephosphorylation occurs at growth arrest. S6 may control cell growth and proliferation through the selective translation of specific of mRNA classes. (NCI)
C29912	RAS-Related_Protein-RRAS2	RAS_Superfamily_Protein	RAS-Related Protein R-RAS2|RAS-Like Protein TC21|RRAS2|Related RAS Viral (R-Ras) Oncogene Homolog 2|TC21	Encoded by human RRAS2 Gene (RAS GTPase Family), ubiquitous 204-aa 23-kDa RAS-Related Protein R-RAS2 is a plasma membrane-associated GTP-binding GTPase that may transduce growth inhibitory signals by exerting an antagonistic effect on a RAS effector. RRAS2 may be posttranslationally modified by palmitoylation and polyisoprenylation. Attachment to the inner surface of plasma membrane may require acylation of a C-terminal cysteine. RRAS2 defects can cause ovarian tumors. (NCI)
C29913	RAS-Like_Protein-RRP22	Protein_with_Unknown_or_Unclassified_Function	RAS-Like Protein RRP22|RAS-Related Protein on Chromosome 22|RAS-Related on Chromosome 22|RRP22	The 203-aa 23-kDa RAS-Like Protein RRP22 is expressed in brain by human RRP22 Gene (Small GTPase Family). (NCI)
C29914	R7_Virus	Mouse_Leukemia_Virus	R7 Virus|MoMuSV 124 variant R7|R7|Recombinant 7	This virus is a spontaneous mutant of SV7, a molecular clone of MoMuSV124. Like SV7, R7 induces subcutaneous fibrosarcomas, spleen tumors, and mesentery tumors infiltrated by proliferating vessels lined by transformed endothelial cells. However, it also induces brain lesions. (from Virology. 1997 Sep 15;236(1):213-8)
C29915	RAS_Suppressor_Protein-1	Protein_with_Unknown_or_Unclassified_Function	RAS Suppressor Protein 1|RSP-1|RSU-1|RSU1	Expressed as multiple alternative transcript variants by human RSU1 Gene, RAS Suppressor Protein 1 is likely involved in the RAS signal transduction pathway, growth inhibition, and NGF-induced differentiation. RSU1 contains 7 LRR repeats and may antagonize RAS. (NCI)
C29916	Graffi_Murine_Leukemia_Virus	Mouse_Leukemia_Virus	Graffi Murine Leukemia Virus|Graffi MuLV	A mouse myeloleukemia virus isolated from filtrates of transplantable tumors; a species of gammaretrovirus.
C29917	Gross_Leukemia_Virus	Mouse_Leukemia_Virus	Gross Leukemia Virus|GLV
C29918	Inactivated_Vaccinia_Virus	Biological_Agent	Inactivated Vaccinia Virus	A poxvirus made non-infectious by ultraviolet light or other inactivation methods in order to reduce its pathogenicity. In cancer gene therapy, inactivated vaccinia virus may be used as a vector to express a protein that kills tumor cells or elicits specific anti-tumor immunity.  In a cancer vaccine application, tumor cells taken from the host may be adsorbed with inactivated vaccinia virus and returned to the host, where the modified tumor cells may stimulate an anti-tumor immune response. (NCI04)
C29919	LIM_Domains_Containing_1	Ligand_Binding_Protein	LIM Domains Containing 1|LIM Domains Containing Protein 1|LIMD1	LIM Domains Containing 1 is encoded by the LIMD1 gene. LIM domains consist of a cysteine-rich consensus sequence containing two distinct zinc-binding subdomains, which mediate protein-protein interactions. The predicted protein sequence reveals three LIM domains located at the C-terminal end, which indicates that it belongs to the group 3 of the gene family encoding LIM motifs. The LIM motif has been previously identified in many developmentally important factors from various eukaryotes. These factors have been shown to play a role in intracellular signaling, transcriptional regulation and cellular differentiation during development. The LIMD1 gene may have a role in tumor suppression. (from PubMed)
C29920	RYK_Receptor-Like_Tyrosine_Kinase	Protein_Tyrosine_Kinase	RYK Receptor-Like Tyrosine Kinase|Hydroxyaryl-Protein Kinase|RYK|RYK1|Tyrosine-Protein Kinase RYK	Widely expressed by human RYK Gene (TYR Kinase Family), 604-aa 68-kDa (precursor) RYK Receptor-Like Tyrosine Kinase is a potential growth factor receptor protein tyrosine kinase, containing a WIF domain, that differs from other family members at a number of conserved residues in the activation and nucleotide binding domains. RYK does not appear to be regulated by phosphorylation in the activation segment and mediation of biological activity may occur by recruitment of a signaling-competent auxiliary protein. (NCI)
C29921	Receptor_Serine-Threonine_Kinase	Cell_Surface_Receptor	Receptor Serine/Threonine Kinase	Encoded by Receptor Serine/Threonine Kinase Genes, Receptor Serine/Threonine Kinases bind to specific signaling factors causing a conformational and functional change in the ligand-bound receptor, altering its interaction with target molecules, increasing the receptor kinase activity, and leading to changes in cellular physiology through modification of the activity of one or more signal transduction pathways.
C29922	LIM_Domain_Kinase-1	Serine-Threonine_Protein_Kinase	LIM Domain Kinase 1|EC 2.7.1.37|LIM KINASE|LIMK-1|LIMK1	LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Two splice variants have been identified. (LocusLink)
C29923	PINCH_Protein	Ligand_Binding_Protein	LIM and Senescent Cell Antigen-Like Domains 1|LIMS1	LIM and Senescent Cell Antigen-Like Domains 1, encoded by the LIMS1 gene, is an adaptor protein which contains five LIM domains, or double zinc fingers. This protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. (LocusLink)
C29924	S100_Calcium_Binding_Protein	Calcium_Binding_Protein	S100 Calcium Binding Protein	Encoded by S100 Family Gene members, S100 Calcium Binding Proteins, localized in the cytoplasm and/or nucleus of many cells, often regulate cellular processes such as cell cycle progression and differentiation.
C29925	S100_Calcium_Binding_Protein-A11	S100_Calcium_Binding_Protein	S100 Calcium Binding Protein A11|Calgizzarin|MLN 70|S100A11|S100C Protein	Encoded by human S100A11 Gene (S100 Family), 105-aa 12-kDa homodimeric S100 Calcium Binding Protein A11, containing 2 EF-hand calcium-binding motifs, may function in motility, invasion, and tubulin polymerization. (NCI)
C29926	S100_Calcium_Binding_Protein-A12	S100_Calcium_Binding_Protein	S100 Calcium Binding Protein A12|CAAF1|CAGC|CGRP|Calcium-Binding Protein In Amniotic Fluid 1|Calgranulin C|ENRAGE|MRP6|Neutrophil S100 Protein|S100A12|p6	Expressed in monocytes and lymphocytes by human S100A12 Gene (S100 Family), 91-aa 10-kDa (precursor) homodimeric S100 Calcium Binding Protein A12, containing 2 EF-hand calcium-binding motifs, is involved in regulatory effects on cytoskeletal components and in calcium-dependent signal transduction pathways. (NCI)
C29927	S100_Calcium_Binding_Protein-A8	S100_Calcium_Binding_Protein	S100 Calcium Binding Protein A8|CAGA|CFAG|CGLA|CP-10|Calgranulin A|Calprotectin L1L Subunit|Cystic Fibrosis Antigen|L1Ag|Leukocyte L1 Complex Light Chain|MIF|MRP8|Migration Inhibitory Factor-Related Protein 8|NIF|S100A8|p8	Constitutively expressed in epithelial cells and in macrophages during chronic inflammation by human S100A8 Gene (S100 Family), 93-aa 11-kDa homodimeric S100 Calcium Binding Protein A8, containing 2 EF-hand calcium-binding motifs, may interact with intermediate filament components and function in casein kinase inhibition. (NCI)
C29928	S100_Calcium_Binding_Protein-A9	S100_Calcium_Binding_Protein	S100 Calcium Binding Protein A9|CAGB|CFAG|CGLB|Calgranulin B|Calprotectin L1H Subunit|L1Ag|Leukocyte L1 Complex Heavy Chain|MIF|MRP14|Migration Inhibitory Factor-Related Protein 14|NIF|S100 Calcium-Binding Protein A9|S100A9|p14	Constitutively expressed in epithelial cells and in macrophages within inflamed tissues by human S100A9 Gene (S100 Family), 114-aa 13-kDa S100 Calcium Binding Protein A9, containing 2 EF-hand calcium-binding motifs, may inhibit protein kinases and interact with intermediate filament components. Altered expression of S100A9 is associated with cystic fibrosis. (NCI)
C29929	S100_Calcium_Binding_Protein-P	S100_Calcium_Binding_Protein	S100 Calcium Binding Protein P|S100P|S100P Protein	Encoded by human S100P Gene (S100 Family), 95-aa 10-kDa S100 Calcium Binding Protein P, containing 2 EF-hand calcium-binding motifs, binds Ca2+, Zn2+, and Mg2+ and interacts with S100Z. (NCI)
C29930	SRC_Family_Associated_Phosphoprotein-2	Adaptor_Signaling_Protein	SRC Family Associated Phosphoprotein 2|FYN-Associated Phosphoprotein SKAP55 Homologue|SAPS|SCAP2|SKAP55-Related Protein|SKAP55R|SRC Kinase-Associated Phosphoprotein of 55-Related Protein|SRC-Associated Adaptor Protein	Expressed in lung, skeletal muscle, kidney, peripheral leukocytes, spleen, brain, placenta, heart, prostate, testis, ovary, and colon by human SCAP2 Gene (SRC Kinase Family), 359-aa SRC Family Associated Phosphoprotein 2, an adaptor protein implicated in myeloid differentiation and growth arrest, is thought to play a role in SRC signal transduction pathways of tyrosine and nontyrosine kinase receptors. Like SKAP55, SKAP55R contains a PH domain, multiple tyrosine phosphorylation sites, and an SH3 domain. Unlike SKAP55, SKAP55R has an N-terminal coiled-coil domain. SKAP55R and SKAP55 are phosphorylated by FYN, but not LCK or ZAP70. Unlike SKAP55, SKAP55R is not constitutively phosphorylated in T cells. FYB in T cells binds SKAP55 and SKAP55R through their SH3 domains. (NCI)
C29931	Secretin_Receptor	G_Protein-Coupled_Receptor	Secretin Receptor|Pancreatic Secretin Receptor|SCTR	Encoded by human SCTR Gene (GPCR2 Family), 440-aa 50-kDa (precursor) 7 transmembrane integral membrane protein Secretin Receptor binds secretin and, mediated by G proteins that activate adenylyl cyclase, regulates pancreatic bicarbonate, enzyme, and potassium ion secretion. (NCI)
C29932	Secreted_and_Transmembrane-1_Protein	Protein_with_Unknown_or_Unclassified_Function	Secreted and Transmembrane 1 Protein|K12 Protein|SECTM1|Type 1a Transmembrane Protein	Widely expressed (highest in myeloid leukocytes) by human SECTM1 Gene, 248-aa 27-kDa (precursor) Secreted and Transmembrane 1 Protein is an integral type 1a transmembrane protein (extracellular N terminus and cleaved signal peptide) found in the Golgi apparatus and thought to be involved in hematopoietic and/or immune system processes. K12 interacts with CD7 and an approximately 20-kD soluble form is secreted by cells. (NCI)
C29933	Ethnicity	Retired_Concepts	Ethnicity|ETHN|Ethnic Group|Ethnic Origin|Ethnic Origins	Ethnicity - an arbitrary classification of the social group a person belongs to, and either identifies with or is identified with by others, as a result of a complex of cultural, biological, geographical and other factors such as linguistic, dietary and religion traditions; ancestry, background, allegiance, or association; and physical characteristics traditionally associated with race. Increasingly the concept is used synonymously with race but this use trend has a pragmatic basis rather than scientific.  Also, sImilar to the concept of ethnic origin which is an attempt to classify people, not according to their current ethnicity, but according to where their ancestors came from.  Ethnic origin has become a popular classification in statistics, where the concept of race has been largely discarded. (from Wikipedia
C29934	Magnetic_Resonance_Spectroscopic_Imaging	Imaging_Technique	Magnetic Resonance Spectroscopic Imaging|1H- Nuclear Magnetic Resonance Spectroscopic Imaging|Proton Magnetic Resonance Spectroscopic Imaging|magnetic resonance spectroscopic imaging	MRSI.  A noninvasive imaging method that provides information about cellular activity (metabolic information).  It is used along with magnetic resonance imaging (MRI) which provides information about the shape and size of the tumor (spatial information).  Also called 1H-nuclear magnetic resonance spectroscopic imaging and proton magnetic resonance spectroscopic imaging.
C29935	Semaphorin-3E	Signaling_Protein	Semaphorin 3E|SEMA3E	Encoded by human SEMA3E Gene (Semaphorin Family), 775-aa 89-kDa (precursor) secreted Semaphorin 3E is a signaling protein containing a Sema domain and an Ig-like C2-type domain. (NCI)
C29936	Proteinase_Inhibitor_Gene	Enzyme_Inhibitor_Gene	Proteinase Inhibitor Gene	Proteinase Inhibitor Genes encode Proteinase Inhibitor Proteins that block the activity of proteases, endopeptidases that catalyze the cleavage of internal peptide bonds in a polypeptide or protein substrate (Serine Endopeptidases, Cysteine Endopeptidases, Aspartic Endopeptidases, Metalloendopeptidases, and other Endopeptidases). (NCI)
C29937	Protease_Inhibitor-14	Enzyme_Inhibitor_Protein	Protease Inhibitor 14|Myoepithelium-Derived Serine Protease Inhibitor|PI14|Pancpin|SERPINI2|Serpin I2|TSA2004	Expressed in pancreas and adipose tissues by human SERPINI2 Gene (PAI-1 Serpin Family), 405-aa 46-kDa (precursor) secreted Protease Inhibitor 14 contains a signal peptide, 3 cysteine residues, and 3 potential N-glycosylation sites. SERPINI2 may have a role in a growth-control, possibly growth-suppression. (NCI)
C29938	Enzyme_Inhibitor_Gene	Gene	Enzyme Inhibitor Gene	Enzyme Inhibitor Genes encode Enzyme Inhibitor Proteins, biological molecules that block or suppress the catalytic activity of enzymes. (NCI)
C29939	Phosphatase-2A_Inhibitor-I2PP2A	Enzyme_Inhibitor_Protein	Phosphatase 2A Inhibitor I2PP2A|2PP2A|HLA-DR Associated Protein II|I2PP2A|IGAAD|Inhibitor of GZMA-Activated DNase|PHAPII|SET|SET Protein|SET Translocation Inhibitor-2 of Protein Phosphatase-2A|TAF-IBeta|Template Activating Factor I Beta	Expressed by human SET Gene (NAP Family) in all tissues and responsive to serum factors, contact inhibition, or differentiation, 277-aa 32-kDa nuclear Phosphatase 2A Inhibitor I2PP2A is a specific inhibitor of PP2A that may be involved in intracellular signaling after ligand activation of HLA class II molecules. Serine phosphorylated SET has a long acidic C-terminus and SET domain. Located in an ER-associated complex containing pp32, HMG2, and APE1, SET is a specific inhibitor of GZMA-activated DNase/nucleoside diphosphate kinase (GAAD/NM23H1), which mediates GZMA-induced caspase-independent apoptosis characterized by single-stranded DNA nicks. GZMA cleavage of SET releases NM23H1 from bound inhibition to SET and results in SET degradation, NM23H1 translocation to the nucleus, and NM23H1 nicking of DNA. (NCI)
C29940	Histone-H3-K9_Methyltransferase-4	Chromatin_Remodeling_Factor	Histone H3-K9 Methyltransferase 4|ERG-Associated Protein with Set Domain|ESET|H3-K9-HMTase 4|Histone-Lysine N-Methyltransferase H3 Lysine-9 Specific 4|SET Domain Bifurcated 1|SETDB1	Widely expressed (high in testis) by human SETDB1 Gene (Suvar3-9 Family) as 2 alternative isoforms, 1291-aa 143-kDa nuclear Histone H3-K9 Methyltransferase 4, excluded from nucleoli and condensed chromatin, methylates histone H3 Lys-9 in epigenetic transcriptional repression that recruits HP1 proteins to methylated histones. SETDB1 contains an MBD domain, a pre-SET, a SET, and a post-SET domain, and 2 Tudor domains; pre-SET, SET and post-SET are required for methyltransferase activity. Isoform 2 lacks all methyltransferase domains. The conserved SET domain is implicated in transcriptional modulation of active or repressed chromatin through remodeling. Targeted to histone by TRIM28/TIF1B, SETDB1 contributes to euchromatic gene silencing by KRAB zinc-finger proteins and may interact with ERG. (NCI)
C29941	Secreted_Frizzled-Related_Protein-4	Signaling_Protein	Secreted Frizzled-Related Protein 4|FRPHE|Frizzled-Related Protein|SFRP4	Encoded by human SFRP4 Gene (SFRP Family), Secreted Frizzled-Related Protein 4 is a soluble modulator of WNT signaling that contains an N-terminal signal peptide, no transmembrane domain, a hydrophilic C terminus, and a Cys-rich domain homologous to the putative WNT-binding site of Frizzled proteins. Involved in cytoskeletal regulation, apoptosis, and proliferation, WNT-mediated simulation of 'Frizzled' receptors can activate beta-catenin, MAPK kinase, and G protein pathways. Bound to WNTs or frizzled receptors, secreted frizzled-related proteins antagonize WNT/frizzled pathways. SFRP4 may inhibit WNT8-mediated development of secondary axes. (NCI)
C29942	SH2-B_Homolog_Protein	Adaptor_Signaling_Protein	SH2-B Homolog|SH2-B Alpha Signaling Protein|SH2-B Gamma Signaling Protein|SH2B	Encoded by human SH2B Gene, SH2-B Homolog is similar to rat (FceRI gamma-chain interacting protein) SH2-B and may be involved in hormone and cytokine cellular signaling pathways. (NCI)
C29943	SH2_Domain_Containing_Protein-3A	Adaptor_Signaling_Protein	SH2 Domain Containing Protein 3A|NSP1|Novel SH2-Containing Protein 1|SH2 Domain Containing Protein 1|SH2D3A	Expressed in placenta, pancreas, kidney, lung, fetal kidney, and fetal lung by human SH2D3A Gene, 76-aa 64-kD adaptor protein SH2 Domain Containing Protein 3A contains a potential SH3 interaction domain. Insulin or EGF induce rapid tyrosine phosphorylation of SH2D3A and increased association with p130-Cas. SH2D3A appears to mediate activation of stress-activated JNK1, but not MAPK1. (NCI)
C29944	SH2_Domain_Containing_Protein-3C	Adaptor_Signaling_Protein	SH2 Domain Containing Protein 3C|CHAT|NSP3|Novel SH2-Containing Protein 3|SH2 Domain-Containing Protein 3|SH2D3C	Expressed in a variety of tissues by human SH2D3C Gene, 698-aa SH2 Domain Containing Protein 3C is a putative adaptor protein containing a potential SH3 interaction domain that may link integrin and tyrosine kinase receptors to the JNK/SAPK pathway. (NCI)
C29945	Recombinant_Vaccinia-Prostate_Specific_Antigen	Viral_Vector-Gene_Complex	Recombinant Vaccinia-Prostate Specific Antigen|Recombinant Vaccinia-PSA|rV-PSA	A recombinant vaccinia virus encoding prostate-specific antigen (PSA).  Vaccination with recombinant vaccinia-PSA stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for PSA, which may decrease tumor growth. (NCI04)
C29946	SH2_Domain_Containing_Transforming_Protein-1	Adaptor_Signaling_Protein	SH2 Domain Containing Transforming Protein 1|SHC|SHC Transforming Protein|SHC Transforming Protein 1|SHC1|SHCA|SRC Homology 2 Domain Containing Protein	Widely expressed as 3 isoforms, p66SHC, p52SHC and p46SHC, by human SHC1 Gene, 583-aa 63-kDa (precursor) cytoplasmic SH2 Domain Containing Transforming Protein 1 is a growth factor receptor adaptor protein containing collagen homology, SH2, SH3, and PID/PTB domains involved in many RAS mitogenic signal transduction pathways. p46, p52, and p66 differ in the N terminals. The PID domain specifically and rapidly binds to the Asn-Pro-Xaa-Tyr(P) motif of tyrosine-phosphorylated proteins. SHC1 is phosphorylated by activated growth factor receptor tyrosine kinases. p66, tyrosine phosphorylated by activated growth factor receptors, complexes with GRB2, an adaptor protein for RAS exchange factor SOS. (NCI)
C29947	Recombinant_Vaccinia-Tyrosinase	Viral_Vector-Gene_Complex	Recombinant Vaccinia-Tyrosinase|Vaccinia/Tyrosinase|rV-TYR
C29948	ACTG2_Gene	Microfilament_Gene	ACTG2 Gene|ACTA3|ACTE|ACTG2|ACTSG|Actin, Gamma 2, Smooth Muscle, Enteric Gene	The ACTG2 gene encodes Actin, Gamma 2, which is a smooth muscle actin found in enteric tissues. Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. (from LocusLink)
C29949	COL1A1_Gene	Collagen_Gene	COL1A1 Gene|COL1A1|Collagen, Type I, Alpha 1 Gene|OI4	The COL1A1 gene encodes Collagen I (Alpha 1), which is the major component of type I collagen, the fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. (from LocusLink)
C29950	COL1A2_Gene	Collagen_Gene	COL1A2 Gene|COL1A2|Collagen, Type I, Alpha 2 Gene|OI4	The COL1A2 gene encodes Collagen I (Alpha 2), one of the chains for type I collagen, the fibrillar collagen found in most connective tissues. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for alpha-1 type I collagen since alpha-2 is less abundant. Multiple messages for this gene result from multiple polyadenylation signals, a feature shared by most of the other collagen genes. (from LocusLink)
C29951	DHPS_Gene	Transferase_Gene	DHPS Gene|DHPS|DS|Deoxyhypusine Synthase Gene	The DHPS gene encodes Deoxyhypusine Synthase. The unusual amino acid hypusine is formed posttranslationally and is only found in a single cellular protein, eukaryotic translation initiation factor 5A. In the first step of hypusine biosynthesis, deoxyhypusine synthase catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the EIF5A precursor protein to form the intermediate deoxyhypusine residue. This gene consists of nine exons spanning 6.6 kb. Three transcript variants have been isolated. However, only transcript variant 1 encodes an active protein. The shorter variants may act as modulating factors of DHPS activity. (from LocusLink)
C29952	EIF4EL3_Gene	Translation_Process_Gene	EIF4EL3 Gene|4E-LP|4EHP|EIF4EL3|Eukaryotic Translation Initiation Factor 4E Member 2 Gene|IF4E	The EIF4EL3 Gene encodes eukaryotic translation initiation factor 4E-like 3, which belongs to the eukaryotic initiation factor 4E family. This protein recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. EIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. (from SWISS-Prot)
C29953	HLA-DPB1_Gene	MHC_Class-II_Gene	HLA-DPB1 Gene|HLA-DP1B|HLA-DPB1|HLADPB1|Major Histocompatibility Complex, Class II, DP Beta 1 Gene	The HLA-DPB1 gene encodes Major Histocompatibility Complex, Class II, DP Beta 1. HLA-DPB, an HLA class II beta chain paralogue, plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). HLA-DPB is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the HLA-DPB molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. (from LocusLink)
C29954	HNRPAB_Gene	Ligand_Binding_Protein_Gene	HNRPAB Gene|ABBP1|HNRPAB|Heterogeneous Nuclear Ribonucleoprotein A/B Gene	The HNRPAB gene encodes Heterogeneous Nuclear Ribonucleoprotein A/B, which belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and they form a component of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It acts as the catalytic component of the multiprotein editosome complex which mediates apolipoprotein B mRNA editing. Two alternatively spliced transcript variants has been described for this gene which encode different isoforms. (from LocusLink)
C29955	LMNB1_Gene	Intermediate_Filament_Gene	LMNB1 Gene|LMN|LMN2|LMNB|LMNB1|Lamin B1 Gene	The human LMNB1 gene encodes Lamin B1, one of the two B type proteins. Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. The lamin family of proteins are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. (from LocusLink and Swiss-Prot)
C29956	MT3_Gene	Ligand_Binding_Protein_Gene	MT3 Gene|GIF|GIFB|GRIF|MT3|Metallothionein 3 (Growth Inhibitory Factor (Neurotrophic)) Gene	The human MT3 gene encodes Metallothionein 3, which belongs to family 1 of the metallothionein superfamily. Metallothionein 3 binds heavy metals. It contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. Metallothionein 3 inhibits survival and neurite formation of cortical neurons in vitro. It is abundant in a subset of astrocytes in the normal human brain, but greatly reduced in the alzheimer's disease (AD) brain. (from Swiss-Prot)
C29957	MYH11_Gene	Microfilament_Gene	MYH11 Gene|KIAA0866|MYH11|Myosin, Heavy Polypeptide 11, Smooth Muscle Gene	The human MYH11 gene encodes Smooth Muscle Myosin Heavy Chain 11, which belonging to the myosin heavy chain family. This protein is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The pericentric inversion of chromosome 16 produces a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Additional splice variants exist. (from LocusLink)
C29958	MYLK_Gene	Serine-Threonine_Protein_Kinase_Gene	MYLK Gene|FLJ12216|KRP|MLCK|MLCK108|MLCK210|MYLK|Myosin, Light Polypeptide Kinase Gene	The MYLK gene encodes Myosin Light Polypeptide Kinase, which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the other arm of chromosome 3. Seven transcript variants that produce seven isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. (from LocusLink)
C29959	NR4A1_Gene	Nuclear_Receptor_Coactivator_Gene	NR4A1 Gene|GFRP1|HMR|MGC9485|N10|NAK-1|NAK1|NGFIB|NP10|NR4A1|NUR77|TR3	The NR4A1 gene encodes Nuclear Receptor Subfamily 4, Group A, Member 1, which is a member of the steroid-thyroid hormone-retinoid receptor superfamily. Its expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. This protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Three transcript variants encoding two distinct isoforms have been identified for this gene. (from LocusLink)
C29960	SNRPF_Gene	Protein_Complex_Subunit_Gene	SNRPF Gene|PBSCF|SMF|SNRPF|Small Nuclear Ribonucleoprotein Polypeptide F Gene	The SNRPF gene encodes Small Nuclear Ribonucleoprotein Polypeptide F, which belongs to the snRNP Sm proteins family. This nuclear protein is associated with sn-RNP U1, U2, U4/U6 and U5. The 4 major small nuclear ribonucleoprotein particles (snRNPs), U1, U2, U4/U6, and U5, are essential components of the eukaryotic pre-mRNA splicing machinery. These snRNPs share 8 proteins which form the snRNP structural core: SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, and SNRPG. These common proteins play an essential role in the biogenesis of the snRNPs. The assembly of the common proteins onto the small nuclear RNA (snRNA) appears to occur in at least 2 steps and involves the formation of RNA-free protein heterooligomers. The common proteins are referred to as Sm proteins because they represent the major targets for the anti-Sm autoantibodies which are diagnostic for SLE. (from OMIM and Swiss-Prot)
C29961	Neuronal-SHC_Protein	Adaptor_Signaling_Protein	Neuronal SHC|NSHC|Neuronal SHC-Like Protein|SHC3|SHCC|SRC Homology 2 Domain Containing Transforming Protein C3	Expressed in the brain by human SHC3 Gene, the 474-aa 52-kD and 594-aa 64-kD isoforms of Neuronal SHC are similar to SHC; nearly 70% homology in the PTB and SH2 domains. SHC3 appears involved in signaling from BDNF/TRKB to the RAS/MAPK pathway. BDNF induces tyrosine phosphorylation of SHC3 and binding to TRKB. Activated EGFR also interacts with and tyrosine-phosphorylates SHC3, inducing an association with GRB2. SHC3 and SCK mediate EGF signaling, but SHC3 has a higher affinity for TRKA and TRKB. (NCI)
C29962	Sonic_Hedgehog_Homolog_Protein	Signaling_Protein	Sonic Hedgehog Homolog|HHG1|SHH|Sonic Hedgehog Protein	Expressed only during embryogenesis by human SHH Gene (Hedgehog Family), 462-aa 50-kDa (precursor) Sonic Hedgehog Homolog is the notochord inductive signal in ventral neural tube and somite patterning and the polarizing signal for anterior-posterior limb axis patterning. The C-terminal domain displays precursor processing autoproteolytic activity that generates the soluble signaling N-portion. With transferase activity, the C-portion covalently attaches cholesterol to the new N-product C-terminus, restricting it to the cell surface and regulating distribution of protein activity throughout the embryo. SHH binds to PTC receptor, releasing constitutive SMO repression and activating target gene transcription. Defects in SHH cause HPE3. (NCI)
C29963	_12q23_1	Chromosome_Band	12q23.1	A chromosome band present on 12q
C29964	_17q21_3-q22_1	Chromosome_Band	17q21.3-q22.1	A chromosome band present on 17q
C29965	_19p13_2-p13_1	Chromosome_Band	19p13.2-p13.1	A chromosome band present on 19p
C29966	_5q35_3	Chromosome_Band	5q35.3	A chromosome band present on 5q
C29967	_5q23_3-q31_1	Chromosome_Band	5q23.3-q31.1	A chromosome band present on 5q
C29968	_16p13_13-p13_12	Chromosome_Band	16p13.13-p13.12	A chromosome band present on 16p
C29969	Signal-Regulatory_Protein_Beta-1	Cell_Surface_Receptor	Signal-Regulatory Protein Beta 1|SIRP Beta 1|SIRPB1	Expressed as 2 alternative isoforms in monocytes and dendritic cells by human SIRPB1 Gene (SIRPB Family/Ig Family), N-glycosylated 398-aa 43-kDa (precursor) type I membrane protein Signal-Regulatory Protein Beta 1 is a cell surface Ig-like transmembrane receptor glycoprotein containing an IgV-type domain and 2 IgC1-type domains involved in negative regulation of receptor tyrosine kinase-coupled signaling. Unlike SIRPAs, SIRPB1 lacks a C-terminal cytoplasmic SHP2-binding domain. SIRPB1 interacts with ITAM protein TYROBP/DAP12, resulting in SYK tyrosine kinase recruitment. (NCI)
C29970	SKI-Like_Protein-SKIL	Transcription_Repressor_Corepressor	SKI-Like Protein SKIL|SKI-Like|SKI-Related Oncogene SNON Protein|SKI-Related Protein|SKIL|SNO|SNOA|SNON	SKI-Like Protein SKIL is widely expressed by human SKIL Gene with immediate early kinetics upon serum stimulation as alternative isoforms: SNON (684-aa), SNOA (415-aa), SNON2, SNOI (skeletal muscle restricted). A component of the TGFB/SMAD pathway, SNON interacts with SMAD2/3 and regulates cell growth and cell differentiation signaling. Absent TGFB, SNON binds nuclear SMAD4 and represses target gene promoter activity. APC activator CDH1 forms a complex with SNON, SMAD3, and TGFB-regulated ubiquitin ligase APC, regulating SNON degradation. TGFB activates SMAD2/3/4 nuclear translocation. SNON degradation allows SMAD2/4 to activate TGFB target genes. TGFB also induces SNON expression, which binds to SMAD complexes and shuts off TGFB signaling. (NCI)
C29971	Helicase-SKI2W	RNA_Helicase	Helicase SKI2W|HLP|Helicase-Like Protein|SKIV2L|Superkiller Viralicidic Activity 2-Like Homolog	Encoded by human SKIV2L Gene (SKI2 Helicase Family), 1246-aa 138-kDa Helicase SKI2W is a conserved DEAD box protein yeast SKI2 homologue containing a leucine zipper domain, motifs associated with RNA helicases, and ATPase activity that may be involved in antiviral activity by blocking translation of poly(A) deficient mRNAs. Conserved motif DEAD box RNA helicases are implicated in translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Rapid 3-prime-to-5-prime degradation of unstable mammalian mRNAs containing 3-prime UTR AU-rich elements (AREs) is mediated by the multisubunit exosome. ARE-binding proteins interact with the exosome and recruit it to ARE-containing RNAs, promoting their degradation. Helicase SKI2W is an exosome-associated factor. (NCI)
C29972	S-Phase_Kinase-Associated_Protein-2	Cell_Cycle_Protein	S-Phase Kinase-Associated Protein 2|CDK2/Cyclin A-Associated Protein p45|Cyclin A/CDK2-Associated Protein p45|F-Box Protein SKP2|SKP2|p45 SKP2	Expressed by human SKP2 Gene (F-Box Family) as 3 alternative isoforms, alpha (42-aa 48-kDa), beta (410-aa), and gamma (442-aa), S-Phase Kinase-Associated Protein 2 contains an F-box domain and 10 tandem LRR repeats. SKP2 acts as a substrate recognition component of the SCF E3 ubiquitin ligase complex, which mediates ubiquitination and proteasomal degradation of target proteins involved in cell cycle progression, signal transduction, and transcription. SKP2 interacts with CUL1, SKP1, and CKS1, and with the Cyclin A/CDK2 complex as an essential element of Cyclin A/CDK2 S-Phase Kinase. Involved in the G1/S transition, SKP2 specifically recognizes phosphorylated CDKN1B/p27KIP predominantly in S phase and interacts with S-phase p19SKP1. CDKN1B/p27KIP degradation also requires CKS1. (NCI)
C29973	PUVA_Photochemotherapy	UVA_Light_Therapy	PUVA Photochemotherapy|PUVA
C29974	Sodium_Chloride	Electrolyte_Replacement_Agent	Sodium Chloride|SODIUM CHLORIDE|Saline|Salt
C29975	Recombinant_Fowlpox-GM-CSF	Viral_Vector-Gene_Complex	Recombinant Fowlpox-GM-CSF|rF-GM-CSF	A cancer vaccine comprised of a recombinant fowlpox virus vector encoding the protein cytokine GM-CSF. GM-CSF is a protein cytokine secreted by T cells and macrophages, following cell activation by antigens or mitogens, and is indispensable for the growth and development of granulocyte and macrophage progenitor cells.  Fowlpox virus is an attractive vaccine vector because its genome is easy to manipulate and it does not multiply in human tissues. (NCI04)
C29976	Recombinant_Vaccinia-GM-CSF	Viral_Vector-Gene_Complex	Recombinant Vaccinia-GM-CSF|rV GM-CSF|rV-GM-CSF	A recombinant vaccinia virus that encodes granulocyte-macrophage colony stimulating factor (GM-CSF).  By activating T-cells and macrophages, vaccination with recombinant vaccinia GM-CSF may enhance the host immune system response to poorly immunogenic tumors, resulting in decreased tumor growth. (NCI04)
C29977	Chloride_Anion_Exchanger	Ion_Channel_Protein	Chloride Anion Exchanger|CLD|DRA Protein|Down-Regulated in Adenoma Protein|Solute Carrier Family 26 Member 3	Encoded by human SLC26A3 Gene (SLC26A/SulP Transporter Family), 764-aa 85-kDa Chloride Anion Exchanger is a sulfate/chloride/bicarbonate transmembrane glycoprotein exchange transporter containing 1 STAS domain and localized in lower intestinal columnar epithelial apical membranes and some goblet cells. Involved in absorbtion, SLC26A3 mediates electrolyte and fluid absorption. Defects in SLC26A3 are the cause of congenital chloride diarrhea (CLD). (NCI)
C29978	Neuronal-SHC_Adaptor_Homolog_Protein	Adaptor_Signaling_Protein	SHC Transforming Protein 2|Neuronal SHC Adaptor Homolog|SCK|SHC-Like Protein SCK|SHC2|SHCB|SLI|Src Homology 2 Domain Containing Transforming Protein 2	Broadly expressed (highest in liver, pancreas, prostate, ovary, and brain) by human SLI Gene, 489-aa Neuronal SHC Adaptor Homolog contains a conserved N-terminal PTB domain, a CH domain, and a conserved C-terminal SH2 domain, as well as unique proline-rich motifs that may be SH3 recognition sites. SCK and NSHC mediate EGF signaling and both bind to neurotrophic receptors TRKA and TRKB. SCK appears to specifically associate with cytoplasmic c-SRC tyrosine kinase CSK (phosphorylated by SRC), which downregulates c-SRC kinase through C-terminal tyrosine phosphorylation. (NCI)
C29979	Secretory_Leukocyte_Protease_Inhibitor	Serine_Proteinase_Inhibitor	Secretory Leukocyte Protease Inhibitor|ALP|Antileukoproteinase|BLPI|HUSI-1|MPI|Mucus Proteinase Inhibitor|Protease Inhibitor WAP4|SLPI|Seminal Proteinase Inhibitor|WAP Four-Disulfide Core Domain Protein 4	Encoded by human SLPI Gene, 132-aa 14-kDa (precursor) Secretory Leukocyte Protease Inhibitor is an acid-stable proteinase inhibitor with 2 WAP-type domains found in seminal plasma, cervical mucus, and bronchial secretions. With affinity for trypsin, chymotrypsin, leukocyte elastase, and cathepsin G, SLPI contributes to the immune response by protecting epithelial surfaces from attack by endogenous serine proteases. (NCI)
C29980	Smoothened_Homolog_Protein	G_Protein-Coupled_Receptor	Smoothened Homolog|Gx Protein|SMO|SMOH|Smoothened	Encoded by human SMO Gene (FZ/SMO GPCR Family), 787-aa 86-kDa (precursor) Smoothened Homolog is a 7-transmembrane G protein-coupled receptor containing 1 FZ domain that seems to form a complex with PTCH to transduce the SHH signal. SHH binding to the PTCH receptor appears to relieve constitutive SMO repression by PTCH and to activate target gene transcription. Sonic Hedgehog Homolog is the notochord inductive signal in ventral neural tube and somite patterning and the polarizing signal for anterior-posterior limb axis patterning. SMO defects are involved in BCC. (NCI)
C29981	Ibritumomab_Tiuxetan	Immunoconjugate	Ibritumomab Tiuxetan	ZEVALIN (Ibritumomab Tiuxetan) is the immunoconjugate resulting from a stable thiourea covalent bond between the monoclonal antibody Ibritumomab and the linker-chelator tiuxetan.  This linker-chelator provides a high affinity, conformationally restricted chelation site for Indium-111 or Yttrium-90.  The ZEVALIN therapeutic regimen is administered in two steps: Step 1 includes one infusion of Rituximab preceding In-111 ZEVALIN. Step 2 follows Step 1 by seven to nine days and consists of a second infusion of Rituximab followed by Y-90 ZEVALIN.  ZEVALIN is supplied as two separate and distinctly labeled kits that contain all of the non-radioactive ingredients necessary to produce a single dose of In-111 ZEVALIN and a single dose of Y-90 ZEVALIN, both essential components of the ZEVALIN therapeutic regimen. (from http://www.rxlist.com)
C29982	ALVAC-CEA_6D_B7_1_Vaccine	ALVAC-CEA_Vaccine	ALVAC-CEA (6D)-B7.1 Vaccine|ALVAC-CEA (6D)-B7.1	A cancer vaccine consisting of ALVAC, a highly attenuated poxvirus strain derived from the canarypox virus.  ALVAC-CEA (6D)-B7.1 vaccine expresses both a highly immunogenic analogue (6D) of the immunodominant epitope of carcinoembryonic antigen (CEA) and B7.1 (also known as CD80), the natural ligand for the T-cell antigen CD28. This agent was designed to stimulate host immune responses against tumor cells that express CEA. (NCI04)
C29983	Anti-MUC-1_Monoclonal_Antibody	Monoclonal_Antibody	Anti-MUC-1 Monoclonal Antibody|Anti-MUC-1
C29984	Fluorouracil_Interferon-alpha_Interleukin-2_Leucovorin-Calcium	Chemotherapy_Regimen	Fluorouracil/Interferon alpha/Interleukin-2/Leucovorin Calcium|IFN/5FU/IL2/Leucovorin
C29985	Interleukin-1-beta_New_Formulation	Therapeutic_Interleukin-1	Interleukin-1-beta New Formulation|IL-1 beta New Formulation	An aqueous therapeutic analogue of the endogenous cytokine interleukin-1-beta (IL-1-beta). Produced mainly by monocytes, endogenous IL-1-beta plays a role in hematopoiesis, is a potent stimulator of T-cell activity, and may promote or inhibit tumor growth, depending on tumor type. (NCI04)
C29986	Interleukin-2_Jurkat_Derived	Therapeutic_Interleukin-2	Interleukin-2 Jurkat Derived|IL-2 Jurkat Derived	A glycoprotein cytokine produced by the human leukemia T-cell line Jurkat. As a paracrine factor, IL-2 drives the expansion of antigen- specific cells and stimulates B cell, NK cell and LAK cell activities. (NCI04)
C29987	Lidocaine_Oral_Solution	Topical_Preparation	Lidocaine Oral Solution|Viscous Lidocaine HCl
C29988	Lidocaine_Patch	Skin_Patch	Lidocaine Patch	A transdermal patch containing 5 percent lidocaine, that releases lidocaine into the body through the skin. It is used as a peripheral analgesic.
C29989	Lidocaine_Topical	Topical_Preparation	Lidocaine Topical
C29990	Monoclonal_Antibody_CC-46	Monoclonal_Antibody	Monoclonal Antibody CC-46|MOAB CC-46/TAG72	A recombinant monoclonal antibody directed against colon cancer (CC) epitopes, tumor-associated glycoprotein 72 (TAG72).  TAG72 is expressed in gastric, breast, pancreatic, colorectal, and ovarian carcinomas. (NCI04)
C29991	Serum-Inducible_Kinase	Serine-Threonine_Protein_Kinase	Serum-Inducible Kinase|SNK|Serine/Threonine-Protein Kinase SNK	Ubiquitously expressed by human SNK Gene (CDC5/Polo Ser/Thr Kinase Family), 685-aa 78-kDa Serum-Inducible Kinase contains an ATP-binding motif within the kinase domain and 2 POLO box domains. Highly similar to CNK and 97% identical to mouse and rat proteins, SNK may play a role in division of some cell types, in embryogenesis, or in wound healing. (NCI)
C29992	Cyclin-E_Binding_Protein-1	Ligand_Binding_Protein	Cyclin-E Binding Protein 1|CEB1|Cyclin E-Binding Protein 1|hect domain and RLD 5	Cyclin-E Binding Protein 1, encoded by the CEB1 gene, specifically interacts with cyclin E, as well as other cyclins tested, even in the absence of p21. CDK inhibitors, however, including p21 and p27, show either weak or no interaction with CEB1. The expression of CEB1 appears to be regulated by RB and p53. CEB1 may regulate or mediate the activity of CDKs because CEB1 is highly induced when both RB and p53 are inactivated, with subsequent elevation of CDK activity. (from OMIM)
C29993	SKI-Interacting_Protein	Transcription_Coactivator	SKI-Interacting Protein|BX42 Homolog|NCOA-62|Nuclear Protein SKIP|Nuclear Receptor Coactivator 62-kD|Nuclear Receptor Coactivator NCOA-62|SKIIP|SKIP|SNW1|SNW1 Protein	Encoded by human SNW1 Gene (SNW Family), 536-aa 61.5-kDa nuclear coactivator SKI-Interacting Protein binds to vitamin D receptor ligand-binding domain and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. SNW1 interacts with a region of SKI oncoproteins required for transforming activity and can interact with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. (NCI)
C29994	Signal_Recognition_Particle-19kDa	RNA_Binding_Protein	Signal Recognition Particle 19kDa|SRP19	Expressed by human SRP19 Gene (SRP19 Family), 144-aa cytoplasmic Signal Recognition Particle 19kDa, with 7 C-terminal Lys interrupted by 2 Gly residues, is involved in signal-recognition-particle assembly (SRP). Monomeric SRP19 mediates binding of the monomeric 54-kDa subunit and binds directly to the SRP 7SLRNA helix 6 stem-loop structure. Mediating signal recognition, translational arrest, and ER targeting by docking protein interaction, the SRP complex consists of a 7SLRNA and SRP9, SRP14, SRP19, SRP54, SRP68, and SRP72 protein subunits. SRP9/SRP14 (Alu domain) and SRP68/SRP72 (S domain) bind to 7SLRNA as heterodimers. (NCI)
C29995	Sushi-Repeat_Protein	Protein_with_Unknown_or_Unclassified_Function	Sushi-Repeat Protein|SRPUL|SRPX2|Sushi-Repeat Containing Protein	Human Sushi-Repeat Protein is encoded by SRPUL Gene. (NCI)
C29996	Spectrin_SH3-Domain_Binding_Protein-1	Adaptor_Signaling_Protein	Spectrin SH3 Domain Binding Protein 1|ABI1|ABL-Interactor Protein 1|E3B1|EPS8 Binding Protein|Interactor Protein ABLBP4|NAP1|NAP1 Binding Protein|SSH3BP1|Spectrin SH3 Binding Protein	Encoded by human SSH3BP1 Gene, Spectrin SH3 Domain Binding Protein 1 contains similarity to homeotic proteins, several polyproline stretches, and a C terminal SH3 domain required for binding to ABL proteins. Binding SH3 domains of EPS8, SSH3BP1 adaptor protein holds EGFR substrate EPS8 in complex with SOS1, mediating RAS signal transduction to RAC (activation) by regulating RAC-specific GEF activity. Depending on its association with SSH3BP1 or RNTRE, EPS8 participates in EGFR signaling through RAC or in EGFR trafficking through RAB5. EPS8 interacts through its SH3 domain with the EGFR-regulated RAB5 GAP RNTRE, which inhibits EGFR internalization. EPS8 diversion from RAC-activation by RNTRE, results in RAC signaling attenuation. (NCI)
C29997	Sarcospan	Cell_Adhesion_Molecule	Sarcospan|KRAG|KRAS Oncogene-Associated Protein|Kirsten-RAS Associated Protein|SPN1|SPN2|SSPN	Expressed in a variety of tissues (muscle highest) by human SSPN Gene, integral membrane protein Sarcospan is a component of the sarcolemma dystrophin-glycoprotein complex (DGC) that spans the muscle plasma membrane and links the F-actin cytoskeleton with the extracellular matrix. Isoform 1 (243-aa, 26.6-kDa) is expressed in heart and skeletal muscle; isoform 2 (132-aa) in heart, skeletal muscle, thymus, prostate, testis, ovary, small intestine, colon, and spleen. SSPN preferentially associates with the DGC sarcoglycan subcomplex and may be found in myotendinous junctions and in postsynaptic membrane of neuromuscular junctions. (NCI)
C29998	Heat_Shock_70kD_Protein_Binding_Protein	Regulatory_Protein	Heat Shock 70kD Protein Binding Protein|HIP|HSC70 Interacting Protein|HSP70 Interacting Protein|Progesterone Receptor-Associated p48 Protein|Putative Tumor Suppressor ST13|ST13|Suppression of Tumorigenicity 13	Encoded by human candidate tumor suppressor gene ST13 Gene, cytoplasmic 369-aa 41-kDa homotetrameric Heat Shock 70kD Protein Binding Protein is an adaptor protein containing 3 TPR repeats involved in assembly of glucocorticoid receptor, which requires the assistance of multiple chaperones. Dependent on HSC70 ATPase activation by HSP40, ST13 oligomer binds HSC70 ATPase domains and stabilizes the HSC70 ADP state that has high affinity for substrate protein. ST13 mediates HSP70 and HSP90 association and may interact with DNAJ homologs. Gene expression is downregulated in colorectal carcinoma. (NCI)
C30000	CTP-37-DT_Vaccine	Anti-human_Chorionic_Gonadotropin_Vaccine	CTP-37-DT Vaccine|Anti-human Chorionic Gonadotropin Vaccine|Avicine|CTP37-DT	A vaccine composed of two synthetic peptides derived from beta-human chorionic gonadotropin (hCG) conjugated to diphtheria toxoid that elicits an anti-human chorionic gonadotropin immune response against hCG-producing cancer cells. (NCI)
C30001	Link_Guanine_Nucleotide_Exchange_Factor-II	Guanine_Nucleotide_Exchange_Factor	Link Guanine Nucleotide Exchange Factor II|LOC51195|Link-GEFII	Link Guanine Nucleotide Exchange Factor II, encoded by the Link-GEFII gene, is a Rap guanine nucleotide exchange factor enriched highly in the basal ganglia. This protein is a Ras guanyl nucleotide-releasing protein with calcium- and diacylglycerol-binding motifs. (from LocusLink and PubMed)
C30002	BCSC-1	Protein_with_Unknown_or_Unclassified_Function	BCSC-1|Breast Cancer Suppressor Candidate 1|LOH11CR2A|Loss of Heterozygosity 11 Chromosomal Region 2 Gene A Protein	BCSC-1, encoded by the LOH11CR2A gene, is a predicted 438-amino acid protein. The LOH11CR2A coding region is composed of 10 exons and spans 30 to 40 kb. There are at least 2 additional exons encoding the 5-prime untranslated region. LOH11CR2A is expressed ubiquitously as a 3.3-kb mRNA. BCSC-1 is a putative tumor suppressor, but unlikely to be involved in the tumorigenic process. (from LocusLink and OMIM)
C30003	Suppression_of_Tumorigenicity-7_Protein	Protein_with_Unknown_or_Unclassified_Function	Suppression of Tumorigenicity 7 Protein|ST7	Widely expressed as different isoforms in nonepithelial tissues (heart, skeletal muscle, brain, lung, placenta and pancreas) by human ST7 Gene, highly conserved 859-aa 95-kDa Suppression of Tumorigenicity 7 Protein is a likely type II membrane protein, containing 2 CUB domains and 5 LDL-R Class A domains, that may act as a tumor suppressor. (NCI)
C30004	Stanniocalcin-1	Peptide_Hormone	Stanniocalcin 1|STC1	Expressed in most tissues (ovary, prostate, heart, kidney, and thyroid highest) by human STC1 Gene (Stanniocalcin Family), 247-aa 28-kDa (precursor) secreted Stanniocalcin 1 is a homodimeric 35-kD glycoprotein hormone involved in calcium homeostasis and renal phosphate reabsorption. In kidney, expression is confined to the distal convoluted tubule and the collecting tubule. STC1 is 96% identical to mouse protein and 73% similar to fish STC. Serine phosphorylation by PKC may regulate activity. Ovarian STC may signal between thecal-interstitial cells and the corpus luteum and oocyte. (NCI)
C30005	Stanniocalcin-2	Peptide_Hormone	Stanniocalcin 2|STC-Related Protein|STC2|STCRP|Stanniocalcin-Related Protein	Widely expressed in muscle and heart (strongest), pancreas, kidney, spleen, prostate, small intestine, colon, and peripheral leucocytes by human STC2 Gene (Stanniocalcin Family) at 5q35.2 encodes 302-aa Stanniocalcin 2, a constitutively secreted disulfide-linked homodimeric 32-kD protein that regulates calcium and phosphate homeostasis. STC2 shares 34% identity with STC1; human and mouse proteins are nearly 88% identical. A Cys-rich N-terminal region may mediate homodimerization. STC2 function on kidney phosphate transport appears to be opposite STC1. STC2 may be serine phosphorylated by a casein kinase-2 ecto-protein. STC2 is likely phosphorylated on serine 288. Phosphorylation may regulate calcium and phosphate homeostasis activity. (NCI)
C30006	Serine-Threonine_Kinase-6	Serine-Threonine_Protein_Kinase	Serine/Threonine Kinase 6|Aurora-A|Aurora-Related Kinase 1|Aurora/IPL1-Like Kinase|Aurora/IPL1-Related Kinase 1|Breast-Tumor-Amplified Kinase|IPL1-Related Kinase|STK15|STK6|Serine/Threonine Kinase 15|hARK1	Expressed in testis, skeletal muscle, thymus, and spleen by human STK6 Gene (Aurora Ser/Thr Kinase Family), 403-aa 45.8-kDa Serine/Threonine Kinase 6 is a phosphorylated cell cycle-regulated kinase localized on centrosomes in interphase cells and at spindle poles in mitosis. Cell cycle-regulated expression accumulates in G2/M and decrease rapidly thereafter. STK6 appears to be involved in cell cycle-regulated microtubule formation and/or stabilization of the spindle pole region during chromosome segregation in anaphase and telophase. STK6 defects are responsible for centrosome aberrations, including aneuploidy. (NCI)
C30007	Protein_Translation_Factor-SUI1_Homolog_Protein	Initiation_Factor	Protein Translation Factor SUI1 Homolog|Putative Translation Initiation Factor|SUI1|Sui1iso1|Translation Initiation Factor 1	Encoded by human SUI1 Gene (SUI1 Family), 113-aa 12.7-kDa Protein Translation Factor SUI1 Homolog is a putative negative growth regulator likely involved in translation. (NCI)
C30010	US_State	Geographic_Area	State|US State	One of the fifty states which is a member of the federation known as the United States of America. Other US geographic areas, such as Puerto Rico and the District of Columbia, are essentially equivalent to State when used in an address. (from Wikipedia and NCI)
C30011	Actin_Gamma-2	Actin	Actin, Gamma 2|ACTG2|Actin, Alpha-3|Actin, Gamma 2, Smooth Muscle, Enteric|Actin, Gamma-Enteric Smooth Muscle|Alpha-Actin 3	Actin, Gamma 2, encoded by the ACTG2 gene, is a smooth muscle actin found in enteric tissues. Actins are highly conserved proteins that are involved in various types of cell motility, and maintenance of the cytoskeleton. In vertebrates, three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. (from LocusLink)
C30012	Cell_Mobility	Cell_Movement	Cell Mobility|Cellular Mobility	Cell Mobility consists of passive translocation of the whole cell, or cell body, from one site to another.
C30013	Collagen_I_Alpha-1	Collagen	Collagen I (Alpha 1)|Alpha 1 Type I Collagen|COL1A1|Collagen Alpha 1(I) Chain|Collagen I, Alpha-1 Polypeptide|Collagen of Skin, Tendon and Bone, Alpha-1 Chain|Collagen of Skin, Tendon, and Bone, Alpha-1 Chain|Collagen, Type I, Alpha 1|Osteogenesis Imperfecta Type IV	Collagen I (Alpha 1), encoded by the COL1A1 gene, is the major component of type I collagen, the fibrillar collagen found in most connective tissues, and the only component of the collagen found in cartilage. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. (from LocusLink)
C30014	Gas_Chromatography	Column_Chromatography	Gas Chromatography|GC	A chromatographic technique in which the stationary phase is solid while the mobile phase is gaseous samples. The gaseous samples are separated based on their different adsorption ability to the solid phase.
C30015	Collagen_I_Alpha-2	Collagen	Collagen I (Alpha 2)|Alpha 2 Type I Collagen|COL1A2|Collagen Alpha 2(I) Chain|Collagen I, Alpha-2|Collagen of Skin, Tendon and Bone, Alpha-2 Chain|Collagen of Skin, Tendon, and Bone, Alpha-2 Chain|Collagen, Type I, Alpha-2	Collagen I (Alpha 2), encoded by the COL1A2 gene, is one of the chains for type I collagen, the fibrillar collagen found in most connective tissues. Mutations in this gene are associated with osteogenesis imperfecta, Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for alpha-1 type I collagen since alpha-2 is less abundant. Multiple messages for this gene result from multiple polyadenylation signals, a feature shared by most of the other collagen genes. (from LocusLink)
C30016	Deoxyhypusine_Synthase	Transferase	Deoxyhypusine Synthase|DHPS|DHS|EC 2.5.1.46	Deoxyhypusine Synthase is encoded by the DHPS gene. The unusual amino acid hypusine is formed posttranslationally and is only found in a single cellular protein, eukaryotic translation initiation factor 5A. In the first step of hypusine biosynthesis, deoxyhypusine synthase catalyzes the NAD-dependent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the EIF5A precursor protein to form the intermediate deoxyhypusine residue. This gene consists of nine exons spanning 6.6 kb. Three transcript variants have been isolated. However, only transcript variant 1 encodes an active protein. The shorter variants may act as modulating factors of DHPS activity. (from LocusLink)
C30017	Amino_Acid_Biosynthesis	Biosynthesis	Amino Acid Biosynthesis	Amino Acid Biosynthesis consists of cellular enzymatic reactions that produce amino acids, organic compounds containing an amino and a carboxyl group and often used in protein synthesis by the formation of peptide bonds during ribosomal translation of mRNA. Several important amino acids, such as the neurotransmitter g-aminobutyric acid, have other functions than protein synthesis.
C30021	Eukaryotic_Translation_Initiation_Factor-4E-Like-3_Protein	Initiation_Factor	Eukaryotic Translation Initiation Factor 4E-Like 3|EIF-4E Type 3|EIF4E Homologous Protein|EIF4E Type 3|EIF4E-Like Cap-Binding Protein|EIF4E-Like Protein 4E-LP|EIF4EL3|Eukaryotic Translation Initiation Factor 4E Homologous Protein|Eukaryotic Translation Initiation Factor 4E Type 3|mRNA Cap-Binding Protein 4EHP|mRNA Cap-Binding Protein Type 3	Eukaryotic Translation Initiation Factor 4E-Like 3, encoded by the EIF4EL3 gene, belongs to the eukaryotic initiation factor 4E family. This protein recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. EIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. (from SWISS-Prot)
C30022	Translation_Process	Gene_Expression_Process	Translation Process	A Translation Process consists of enzymatic reactions by which polypeptides are synthesized on ribosomes from information in mRNA transcripts to specify the sequence of amino acids in the polypeptide chain.
C30023	Translation_Initiation	Translation_Process	Translation Initiation	Translation Initiation consists of cellular and enzymatic reactions that instigate the process by which polypeptides are synthesized on ribosomes from information in mRNA transcripts to specify the sequence of amino acids in the polypeptide chain.
C30024	HLA-DP_Histocompatibility_Type_Beta-1_Subunit	MHC_Class-II_Protein	Major Histocompatibility Complex, Class II, DP Beta 1|HLA Class II Histocompatibility Antigen, DP(W4) Beta Chain|HLA-DP Histocompatibility Type, Beta-1 Subunit|HLA-DPB1|Major Histocompatibility Complex, Class II, DP Beta-1	Major Histocompatibility Complex, Class II, DP Beta 1 is encoded by the HLA-DPB1 gene. HLA-DPB, an HLA class II beta chain paralogue, plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). HLA-DPB is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the HLA-DPB molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. (from LocusLink)
C30025	Heterogeneous_Nuclear_Ribonucleoprotein-AB	RNA_Binding_Protein	Heterogeneous Nuclear Ribonucleoprotein A/B|ABBP-1|APOBEC-1 Binding Protein 1|Apolipoprotein B mRNA-Editing Enzyme, Catalytic Polypeptide 1-Binding Protein 1|HNRNP Core Protein C|HNRPAB|Heterogeneous Nuclear Ribonucleoprotein C|hnRNP A/B|hnRNP Type A/B Protein	Heterogeneous Nuclear Ribonucleoprotein A/B, encoded by the HNRPAB gene, belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are produced by RNA polymerase II and they form a component of the heterogeneous nuclear RNA (hnRNA) complexes. They are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. It acts as the catalytic component of the multiprotein editosome complex which mediates apolipoprotein B mRNA editing. Two alternatively spliced transcript variants has been described for this gene which encode different isoforms. (from LocusLink)
C30026	Transcriptional_Co-Activator-CRSP100	Protein_Complex_Subunit	Cofactor Required for Sp1 Transcriptional Activation Subunit 4|CRSP100|CRSP4	Encoded by human CRSP4 Gene, Cofactor Required for Sp1 Transcriptional Activation Subunit 4 is 100-kD protein of the CRSP (Cofactor Required for SP1 activation) complex, which, along with TFIID, is required for efficient activation of gene transcription by SP1, a transcription factor that recognizes enhancer sites in target DNA. Many CRSP complex proteins are also components of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins that interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. (NCI)
C30027	Transforming_Acidic_Coiled-Coil_Containing_Protein-3	Protein_with_Unknown_or_Unclassified_Function	Transforming Acidic Coiled-Coil Containing Protein 3|ERIC1|TACC3	Expressed in testis, thymus, and other immune system tissues by human TACC3 Gene (TACC Family), 838-aa 90-kDa cytoplasmic Transforming Acidic Coiled-Coil Containing Protein 3, with high amounts of serine, proline, and acidic residues and a tyrosine phosphorylation site, interacts with microtubules and may be involved in control of cell growth and differentiation. The coiled coil C-terminal region may interact with AH receptor nuclear translocator protein (ARNT) and with ARNT2. (NCI)
C30028	Mouse_Ovarian_Disorder	Mouse_Female_Reproductive_System_Disorder	Mouse Ovarian Disorder|Ovarian Disorder	Based on IC of Rodent Tumors: The Mouse
C30029	Mouse_Non-Neoplastic_Ovarian_Proliferative_Disorder	Mouse_Ovarian_Disorder	Mouse Non-Neoplastic Ovarian Proliferative Disorder|Non-Neoplastic Ovarian Proliferative Disorder
C30030	Mouse_Ovarian_Neoplasm	Mouse_Ovarian_Disorder	Mouse Ovarian Neoplasm|Ovarian Neoplasm
C30031	Mouse_Cystic_or_Papillary_Hyperplasia	Mouse_Non-Neoplastic_Ovarian_Proliferative_Disorder	Mouse Cystic or Papillary Hyperplasia|Cystic or Papillary Hyperplasia
C30032	Mouse_Sex_Cord_Stromal_Hyperplasia	Mouse_Non-Neoplastic_Ovarian_Proliferative_Disorder	Mouse Sex Cord Stromal Hyperplasia|Sex Cord Stromal Hyperplasia
C30033	Mouse_Tubulostromal_Hyperplasia	Mouse_Non-Neoplastic_Ovarian_Proliferative_Disorder	Mouse Tubulostromal Hyperplasia|Tubulostromal Hyperplasia
C30034	Mouse_Ovarian_Cysts	Mouse_Non-Neoplastic_Ovarian_Proliferative_Disorder	Mouse Ovarian Cysts|Ovarian Cysts
C30035	Mouse_Ovarian_Angiectasis	Mouse_Non-Neoplastic_Ovarian_Proliferative_Disorder	Mouse Ovarian Angiectasis|Ovarian Angiectasis
C30036	Mouse_Benign_Ovarian_Neoplasm	Mouse_Ovarian_Neoplasm	Mouse Benign Ovarian Neoplasm|Benign Ovarian Neoplasm
C30037	Mouse_Malignant_Ovarian_Neoplasm	Mouse_Ovarian_Neoplasm	Mouse Malignant Ovarian Neoplasm|Malignant Ovarian Neoplasm
C30038	Mouse_Ovarian_Tubulostromal_Adenoma	Mouse_Benign_Ovarian_Neoplasm	Mouse Ovarian Tubulostromal Adenoma|Ovarian Tubulostromal Adenoma
C30039	Mouse_Ovarian_Cystadenoma	Mouse_Benign_Ovarian_Neoplasm	Mouse Ovarian Cystadenoma|Ovarian Cystadenoma
C30040	Mouse_Benign_Luteoma	Mouse_Benign_Ovarian_Neoplasm	Mouse Benign Luteoma|Benign Luteoma
C30041	Mouse_Benign_Ovarian_Teratoma	Mouse_Benign_Ovarian_Neoplasm	Mouse Benign Ovarian Teratoma|Benign Ovarian Teratoma
C30042	Mouse_Benign_Thecoma	Mouse_Benign_Ovarian_Neoplasm	Mouse Benign Thecoma|Benign Thecoma
C30043	Mouse_Benign_Granulosa_Cell_Tumor	Mouse_Benign_Ovarian_Neoplasm	Mouse Benign Granulosa Cell Tumor|Benign Granulosa Cell Tumor
C30044	Mouse_Benign_Sertoli_Cell_Tumor	Mouse_Benign_Ovarian_Neoplasm	Mouse Benign Sertoli Cell Tumor|Benign Sertoli Cell Tumor
C30045	Mouse_Benign_Sex_Cord_Stromal_Mixed_Tumor	Mouse_Benign_Ovarian_Neoplasm	Mouse Benign Sex Cord Stromal Mixed Tumor|Benign Sex Cord Stromal Mixed Tumor
C30046	Mouse_Ovarian_Hemangioma	Mouse_Benign_Ovarian_Neoplasm	Mouse Ovarian Hemangioma|Ovarian Hemangioma
C30047	Mouse_Ovarian_Tubulostromal_Adenocarcinoma	Mouse_Malignant_Ovarian_Neoplasm	Mouse Ovarian Tubulostromal Adenocarcinoma|Ovarian Tubulostromal Adenocarcinoma
C30048	Mouse_Ovarian_Cystadenocarcinoma	Mouse_Malignant_Ovarian_Neoplasm	Mouse Ovarian Cystadenocarcinoma|Ovarian Cystadenocarcinoma
C30049	Mouse_Ovarian_Embryonal_Carcinoma	Mouse_Malignant_Ovarian_Neoplasm	Mouse Ovarian Embryonal Carcinoma|Ovarian Embryonal Carcinoma
C30050	Mouse_Yolk_Sac_Carcinoma	Mouse_Malignant_Ovarian_Neoplasm	Mouse Yolk Sac Carcinoma|Yolk Sac Carcinoma
C30051	Mouse_Choriocarcinoma	Mouse_Malignant_Ovarian_Neoplasm	Mouse Choriocarcinoma|Choriocarcinoma
C30052	Mouse_Malignant_Ovarian_Thecoma	Mouse_Malignant_Ovarian_Neoplasm	Mouse Malignant Ovarian Thecoma|Malignant Ovarian Thecoma
C30053	Mouse_Malignant_Ovarian_Granulosa_Cell_Tumor	Mouse_Malignant_Ovarian_Neoplasm	Mouse Malignant Ovarian Granulosa Cell Tumor|Malignant Ovarian Granulosa Cell Tumor
C30054	Mouse_Malignant_Ovarian_Sertoli_Cell_Tumor	Mouse_Malignant_Ovarian_Neoplasm	Mouse Malignant Ovarian Sertoli Cell Tumor|Malignant Ovarian Sertoli Cell Tumor
C30055	Mouse_Ovarian_Hemangiosarcoma	Mouse_Malignant_Ovarian_Neoplasm	Mouse Ovarian Hemangiosarcoma|Ovarian Hemangiosarcoma
C30056	Mouse_Ovarian_Histiocytic_Sarcoma	Mouse_Malignant_Ovarian_Neoplasm	Mouse Ovarian Histiocytic Sarcoma|Ovarian Histiocytic Sarcoma
C30057	Tachykinin_Receptor-3	G_Protein-Coupled_Receptor	Tachykinin Receptor 3|NK3 Receptor|NK3R|NKR|Neurokinin B Receptor|Neuromedin K Receptor|TAC3RL|TACR3	Encoded by human TACR3 Gene (GPCR1 Family), 465-aa 52-kDa integral membrane protein Tachykinin Receptor 3 is a receptor for the tachykinin neuropeptide Neuromedin K and interacts with G proteins that activate a PI-calcium second messenger system. Receptor anchoring to the plasma membrane is probably mediated by palmitoylation of a cysteine residue. Ligand affinity of the receptor (specified in the 5'-end) to tachykinins is: Neuromedin K > Substance K > Substance P. (NCI)
C30058	TBP-Related_Factor-10	Basal_Transcription_Factor	TBP-Related Factor 10|STAF28|TAF10|TAF10 RNA Polymerase II|TAF2A|TAF2H|TAFII30|TATA Box Binding Protein-Associated Factor 30kDa|TATA Box Binding Protein-Associated Factor RNA Polymerase II H 30kD|TBP-Associated Factor 30kDa|TBP-Associated Factor RNA Polymerase II H 30kD|Transcription Initiation Factor TFIID 30 kDa Subunit	Encoded by human TAF10 Gene (TAF2H Family), 218-aa nuclear Transcription Initiation Factor TFIID 30 kDa Subunit is a small subunit of TFIID and associated with a subset of TFIID complexes. A component of the PCAF complex, the TFTC-HAT complex, and the STAGA transcription coactivator-HAT complex, TAF10 is required for transcriptional activation by estrogen receptor, for cell cycle progression, and may be required for some cell differentiation programs. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals.  (NCI)
C30059	TBP-Associated_Factor-11	Basal_Transcription_Factor	TBP-Associated Factor 11|TAF11|TAF11 RNA Polymerase II|TAFII28|TATA Box Binding Protein-Associated Factor RNA Polymerase II I 28kD|TBP-Associated Factor 28kDa|TBP-Associated Factor RNA Polymerase II I 28kD|TFIID Subunit p30-Beta|Transcription Initiation Factor TFIID 28 kD Subunit	Encoded by human TAF11 Gene (TAF2I Family), 211-aa 23-kDa nuclear TBP-Associated Factor 11 is a small subunit of all TFIID complexes that interacts directly with TBP, interacts with TAFII18, and interacts with TAF13 to form a heterodimer with a structure similar to the histone core structure. TBP and TAFII18 bind to distinct domains of TAF11. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI)
C30060	TBP-Associated_Factor-20kDa	Basal_Transcription_Factor	TBP-Associated Factor 20 kDa|TAF12|TAF12 RNA Polymerase II|TAF2J|TAFII20|TATA Box Binding Protein-Associated Factor 20kDa|TATA Box Binding Protein-Associated Factor RNA Polymerase II J 20kD|TBP-Associated Factor RNA Polymerase II J 20kD|Transcription Initiation Factor TFIID 20 kDa Subunit	Ubiquitously expressed as alternative initiation isoforms by human TAF12 Gene (TAF2J Family), nuclear (18-kDa precursor) TBP-Associated Factor 15 kDa and 20 kDa, similar to Histones H2B and H3, are components of the TFIID complex essential for regulation of transcription. A component of the PCAF complex and the STAGA transcription coactivator-HAT complex, TAF12 interacts directly with TBP and TAF11, as well as with TAFII20 and TAFII30. TFIID is composed of TBP and many TAF proteins. Control of transcription by the RNA polymerase II basal transcription machinery complex is modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to transcription start sites. Some modulators interact directly with the basal complex; others may bridge transactivators to the basal factors. Different TAFs may mediate distinct transcriptional activators. (NCI)
C30061	TBP-Associated_Factor-15kDa	Basal_Transcription_Factor	TBP-Associated Factor 15 kDa|TAF12|TAF12 RNA Polymerase II|TAF2J|TAFII15|TATA Box Binding Protein-Associated Factor 15 kDa|Transcription Initiation Factor TFIID 15 kDa Subunit	Ubiquitously expressed as alternative initiation isoforms by human TAF12 Gene (TAF2J Family), nuclear (18-kDa precursor) TBP-Associated Factor 15 kDa and 20 kDa, similar to Histones H2B and H3, are components of the TFIID complex essential for regulation of transcription. A component of the PCAF complex and the STAGA transcription coactivator-HAT complex, TAF12 interacts directly with TBP and TAF11, as well as with TAFII20 and TAFII30. TFIID is composed of TBP and many TAF proteins. Control of transcription by the RNA polymerase II basal transcription machinery complex is modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to transcription start sites. Some modulators interact directly with the basal complex; others may bridge transactivators to the basal factors. Different TAFs may mediate distinct transcriptional activators. (NCI)
C30062	TBP-Associated_Factor-13	Basal_Transcription_Factor	TBP-Associated Factor 13|TAF13|TAF13 RNA Polymerase II|TAFII18|TATA Box Binding Protein-Associated Factor 18kDa|TBP-Associated Factor 18kDa|Transcription Initiation Factor TFIID 18 kD Subunit	Encoded by human TAF13 Gene (TAF2K Family), 124-aa 14-kDa nuclear TBP-Associated Factor 13 is a small subunit associated with a subset of TFIID complexes (TFIID Beta-specific). TAF13 interacts with TBP and with strongly TAF10 and TAF11; TAF10 and TAF11 binding involves distinct TAFII18 domains. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI)
C30063	TBP-Associated_Factor-2	Basal_Transcription_Factor	TBP-Associated Factor 2|TAF2|TAF2 RNA Polymerase II|TAF2B|TAFII150|TATA Box Binding Protein-Associated Factor 150kDa|TATA Box Binding Protein-Associated Factor RNA Polymerase II B 150kD|TBP-Associated Factor 150kDa|TBP-Associated Factor RNA Polymerase II B 150kD	Encoded by human TAF2 Gene, 1,199-aa TBP-Associated Factor 2 is one of the larger subunits associated with TFIID, shares 53% identity with its Drosophila homologue, and contains a stretch of 7 His residues near the C terminus. Stably associated with TAF2C1, TAF2D, and TBP as an essential cofactor for TFIID/TBP-dependent transcription from promoters containing initiator elements, TAF2B contributes to interactions that determine response of the complex to activators. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI)
C30064	TBP-Associated_Factor-140kDa	Basal_Transcription_Factor	TBP-Associated Factor 140kDa|RNA Polymerase II Transcription Factor TAFII140|TAF140|TAF3|TAF3 RNA Polymerase II|TAFII140|TATA Box Binding Protein-Associated Factor 140kDa	Encoded by human TAF3 Gene, 140-kD nuclear TBP-Associated Factor 140kDa apparently forms complexes with TBP, TAF10, and TAF13, as well as with SAP130 and GCN5. TAF3 contains an N-terminal HFD (interacts with TAF10) and is highly homologous to mouse Tafii140; a PHD finger motif is likely present. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI)
C30065	TBP-Associated_Factor-4	Basal_Transcription_Factor	TBP-Associated Factor 4|TAF2C|TAF2C1|TAF4|TAF4 RNA Polymerase II|TAF4A|TAFII130|TAFII135|TATA Box Binding Protein-Associated Factor 135 kD|TATA Box Binding Protein-Associated Factor RNA Polymerase II C1 130kD|TBP-Associated Factor 135 kD|TBP-Associated Factor RNA Polymerase II C1 130kD|Transcription Initiation Factor TFIID 135 kDa Subunit	Encoded by human TAF4 Gene (TAF2C Family), 1083-aa 110-kDa nuclear TBP-Associated Factor 4, containing 1 TAFH/NHR1 domain, is one of the larger subunits of the multimeric TFIID complex that mediates promoter responses to various activators and repressors. A component of the TFTC-HAT complex, TAF4 interacts with transcription factor CREB and other proteins containing glutamine-rich regions and potentiates transcriptional activation by the AF-2S of the RAR, THR and vitamin D3 receptor. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI)
C30066	TBP-Associated_Factor-5	Basal_Transcription_Factor	TBP-Associated Factor 5|TAF2D|TAF5|TAF5 RNA Polymerase II|TAFII100|TATA Box Binding Protein-Associated Factor|TATA Box Binding Protein-Associated Factor 100kDa|TATA Box Binding Protein-Associated Factor RNA Polymerase II D 100kD|TBP-Associated Factor 100kDa|TBP-Associated Factor 2D|TBP-Associated Factor RNA Polymerase II D 100kD|Transcription Initiation Factor TFIID 100 kD Subunit	Encoded by human TAF5 Gene, alternative 745-aa and 800-aa 87-kDa isoforms of nuclear TBP-Associated Factor 5 interact strongly with (histone H4-related) TAFII80 and (histone H3-related) TAFII31, as well as with TBP, TAFII250, TAFII28, and TAFII20. A component of the TFTC-HAT complex, TAFII100 contains 1 LisH domain and 6 WD repeats; distinct TAFII100 domains are required for interaction with TFIIFB and for incorporation into TFIID. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI)
C30067	TBP-Associated_Factor-6	Basal_Transcription_Factor	TBP-Associated Factor 6|TAF2E|TAF6|TAF6 RNA Polymerase II|TAFII70|TAFII80|TAFII85|TATA Box Binding Protein-Associated Factor 80kDa|TATA Box Binding Protein-Associated Factor RNA Polymerase II E 70/85kD|TBP-Associated Factor 80kDa|TBP-Associated Factor RNA Polymerase II E 70/85kD|Transcription Initiation Factor TFIID 70 kD Subunit	Encoded by human TAF6 Gene (TAF2E Family), 677-aa 73-kDa nuclear TBP-Associated Factor 6, one of the smaller TFIID subunits, binds tightly to TAF1 (the largest subunit of TFIID) to TBP, and directly to TAFII40. Four isoforms have been identified; one isoform precludes binding of another TFIID subunit, reducing transcription and initiating apoptotic signals. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI)
C30068	TBP-Associated_Factor-F	Basal_Transcription_Factor	TBP-Associated Factor F|TAF2F|TAF7|TAF7 RNA Polymerase II|TAFII55|TATA Box Binding Protein-Associated Factor 55kDa|TATA Box Binding Protein-Associated Factor RNA Polymerase II F 55kD|TATA Box-Binding Protein-Associated Factor 2F|TBP-Associated Factor 55kDa|TBP-Associated Factor RNA Polymerase II F 55kD|Transcription Factor IID Subunit TAFII55|Transcription Initiation Factor TFIID 55 kDa Subunit	Encoded by human TAF7 Gene (TAF2F Family), ubiquitous 349-aa 40-kDa nuclear TBP-Associated Factor F is a component of TFIID complex (with or without TAFII30) that binds class II promoter TATA boxes and recruits RNA polymerase II and other factors. TAF7 interacts with TAFII250, TAFII100, TAFII28, TAFII20, TAFII18, and multiple transcription activators. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI)
C30069	TBP-Associated_Factor-50kDa	Basal_Transcription_Factor	TBP-Associated Factor 50kDa|TAF2Q|TAF7-Like RNA Polymerase II|TAF7L|TATA Box Binding Protein-Associated Factor 50kDa|TATA Box Binding Protein-Associated Factor RNA Polymerase II Q|TBP-Associated Factor RNA Polymerase II Q	Expressed specifically in male germ cells (testis) by human TAF7L Gene, TBP-Associated Factor 50kDa is a component of TFIID, composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI)
C30070	Taube_Nuss_Homologue_Protein	Basal_Transcription_Factor	Taube Nuss Homologue|TAF8|TAF8 RNA Polymerase II|TATA Box Binding Protein-Associated Factor 50 kD|TATA Box Binding Protein-Associated Factor RNA Polymerase II A 45-50kD|TBN|TBP-Associated Factor 50 kD|TBP-Associated Factor RNA Polymerase II A 45-50kD	No info. in OMIM, PubMed or HUGO as of 12/09/2003.
C30071	TBP-Associated_Factor-9	Basal_Transcription_Factor	TBP-Associated Factor 9|Adrenal Gland Protein AD-004|STAF31/32|TAF2G|TAF9|TAF9 RNA Polymerase II|TAFII31|TAFII32|TATA Box Binding Protein-Associated Factor 32kDa|TATA Box Binding Protein-Associated Factor RNA Polymerase II G 32kD|TBP-Associated Factor 32kDa|TBP-Associated Factor RNA Polymerase II G 32kD|Transcription Initiation Factor TFIID 31 kD Subunit	Encoded by human TAF9 Gene (TAF2G Family), 264-aa 29-kDa nuclear TBP-Associated Factor 9 is a small TFIID subunit that binds to the basal transcription factor GTFIIB as well as transcriptional activators. A component of the PCAF complex and of the STAGA transcription coactivator-HAT complex, TAF9 is a p53 coactivator and interacts with viral transactivator VP16. TAF9 and TP53 bind via TP53 N-terminal amino acids that are essential for transcription. TFIID is composed of TBP and many evolutionarily conserved TAFs, which participate in basal transcription, serve as coactivators, and function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. Multimeric protein complex TFIID binds to the core promoter to position polymerase, serves as scaffold for assembly of the transcription complex, and acts as a channel for regulatory signals. (NCI)
C30072	T-Cell_Acute_Lymphocytic_Leukemia-2_Protein	BHLH_Protein	T-Cell Acute Lymphocytic Leukemia 2 Protein|T-Cell Acute Lymphocytic Leukemia 2|TAL2|TAL2 Protein	Encoded by human TAL2 Gene, 108-aa 12-kDa bHLH T-Cell Acute Lymphocytic Leukemia 2 Protein has sequence homology to TAL1 and LYL1, bHLH proteins involved in T-cell leukemogenesis. TAL2 also includes a DNA-binding domain homologous to those in TAL1 and LYL1. A T-ALL translocation, t(7;9)(q34;q32), results from a mistake during V(D)J recombination using a fortuitous 3-prime TAL2 recombination site and the TCRB J-beta-2 coding segment that juxtaposes TAL2 with the TCR-beta enhancer and results in TAL2 overexpression. (NCI)
C30073	Intermediate_Filament_Gene	Cytoskeletal_Gene	Intermediate Filament Gene	Intermediate Filament Genes encode a number of different Intermediate Filament Proteins (including keratin filaments, neurofilaments, desmin, and vimentin) that form polymeric structural cytoplasmic filaments, intermediate in diameter (8-10 nanometer) between actin microfilaments and microtubules, which comprise part of the cytoskeleton of most eukaryotic cells. (NCI)
C30074	Lamin-B1	Lamin	Lamin B1|LMNB1	Lamin B1, one of the two B type proteins, is encoded by the human LMNB1 gene. Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. The lamin family of proteins are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. (from LocusLink and Swiss-Prot)
C30075	Metallothionein-3	Metallothionein	Metallothionein 3|GIF|GIFB|Growth Inhibitory Factor|Growth Inhibitory Factor, Brain|Growth Inhibitory Factor, Neurotrophic|MT-III|MT3|Metallothionein III|Metallothionein-III	Metallothionein 3, encoded by the human MT3 gene, belongs to family 1 of the metallothionein superfamily. Metallothionein 3 contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium. It binds heavy metals. Metallothionein 3 inhibits survival and neurite formation of cortical neurons in vitro. It is abundant in a subset of astrocytes in the normal human brain, but greatly reduced in the alzheimer's disease (AD) brain. (from Swiss-Prot)
C30076	Transcriptional_Coactivator_with_PDZ-Binding_Motif	Transcription_Coactivator	WW Domain Containing Transcription Regulator 1|DKFZP586I1419|TAZ|Transcriptional Coactivator with PDZ-Binding Motif|WWTR1	With highest expression in kidney, heart, placenta, and lung by human TAZ Gene, 400-aa 45-kDa Transcriptional Coactivator with PDZ-Binding Motif contains a putative N-terminal 14-3-3 protein-binding motif, a central WW domain, and a C-terminal PDZ-binding motif and 2-stranded coiled-coil. The PDZ-binding domain localizes TAZ to discrete nuclear foci and is required for TAZ-stimulated gene transcription; it also mediates TAZ interaction with SLC9A3R2. Interaction with 14-3-3 appears to require TAZ phosphorylation on a specific serine residue; phosphorylation reduces TAZ transcriptional coactivation by inducing nuclear export through interaction with 14-3-3. TAZ shares 91% identity with mouse Taz and 45% identity with YAP. (NCI)
C30077	TANK-Binding_Kinase-1	Signaling_Protein	TANK-Binding Kinase 1|NAK|NF-KB-Activating Kinase|NF-KB-Activating Kinase NAK|T2K|TANK Binding Kinase TBK1|TBK1	Encoded by human TBK1 Gene, 729-aa 84-kDa TANK-Binding Kinase 1 (similar to IKB kinases) mediates NFKB activation in response to certain growth factors. TBK1 forms a complex with TRAF2 and TANK IKB protein to release NFKB inhibition by TANK. NFKB complex is inhibited by IKB proteins, which trap it in the cytoplasm. IKB serine phosphorylation by IKB kinases marks them for ubiquitinated destruction, allowing NFKB activation and nuclear translocation. (NCI)
C30078	TBP-Like_Protein-1	Basal_Transcription_Factor	TBP-Like Protein 1|21-kDa TBP-Like Protein|STUD Protein|TATA Box Binding Protein-Like Protein 1|TATA Box Binding Protein-Related Factor 2|TBP-Related Factor 2	Ubiquitously expressed (highest in testis and brain) human TBPL1 Gene (TBP Family), encodes 186-aa 21-kDa DNA-binding TBP-Like Protein 1, which serves the same function as TBP, substituting for TBP at some promoters not recognized by TFIID. TBPL1 binds TFIIA and TFIIB, does not bind the TATA box, may be important in expression of some developmentally regulated genes, and is essential for spermiogenesis. (NCI)
C30079	Transcription_Factor-3	Transcription_Factor	Transcription Factor 3|E2A|E2A Immunoglobulin Enhancer Binding Factor E12|E2A Immunoglobulin Enhancer Binding Factor E47|ITF1|Immunoglobulin Transcription Factor 1|Kappa-E2-Binding Factor|TCF3|Transcription Factor E2-Alpha	Encoded by human TCF3 Gene, E12 and E47 alternative isoforms of 654-aa 68-kDa nuclear bHLH Transcription Factor 3 are homologous to MYOD, MYC, 'daughterless', 'achaete-scute' and 'twist' families. As a heterodimer with tissue-specific bHLH proteins (e.g., ASH1 and TWIST2), TCF3 determines diverse cell fates during embryogenesis. TCF3 heterodimers bind DNA on CANNTG E-box motifs, such as kappa Ig gene enhancer E2 sites. TCF3 is likely phosphorylated following NGF stimulation. Crucial in dimerization and DNA binding, the bHLH motif forms 2 amphipathic helices that contain highly conserved hydrophobic residues. TCF3 is involved in B-ALL through a t(1;19)(q23;p13.3) translocation and fusion with PBX1. (NCI)
C30080	Transcription_Factor-7-Like-2_Protein	Transcription_Factor	Transcription Factor 7-Like 2|HMG Box Transcription Factor 4|T-Cell-Specific Transcription Factor 4|TCF4|TCF7L2|hTCF4	Decreasingly expressed from crypt to villus by human TCF7L2 Gene (TCF/LEF Family), nuclear DNA-binding HMG box Transcription Factor 7-Like 2, participates in the WNT pathway and maintains epithelial stem cells of the small intestine. Absent CTNNB1, TCF7L2 acts as a repressor. Bound to the CTNNB1 armadillo repeat in a stable complex, TCF7L2 activates transcription from promoters containing the TCF motif (CCTTTGATC). TCF7L2 binds to the MYC promoter in a sequence-specific manner and modulates MYC expression. The TCF7L2 activation domain binds transcriptional coactivator EP300. TLE1, TLE2, TLE3, and TLE4 repress TCF7L2/CTNNB1 mediated transactivation. Constitutive TCF7L2 activation may promote maintenance of the stem cell phenotype and initiate colorectal cancer. TCF7L2/CTNNB1 may control proliferation versus differentiation in intestinal epithelial cells. (NCI)
C30081	T-Cell_Leukemia_Lymphoma_1B_Protein	Protein_with_Unknown_or_Unclassified_Function	T-Cell Leukemia/Lymphoma 1B|SYN1|Syncytiotrophoblast-Specific Protein|TCL1B|TCL1B Protein	Expressed in a variety of tissues by human TCL1B Gene (TCL1 Family), 128-aa 15-kDa T-Cell Leukemia/Lymphoma 1B has 60% similarity to TCL1A protein and is activated in chronic T-cell leukemias (T-CLL) carrying rearrangements of the 14q32.1 region. (NCI)
C30082	TCTA_Protein	Protein_with_Unknown_or_Unclassified_Function	T-Cell Leukemia Translocation Altered Gene Product|TCTA	Ubiquitously expressed (highest in kidney) 103-aa 11-kDa T-Cell Leukemia Translocation Altered Gene Product is encoded by human TCTA Gene. (NCI)
C30083	TEC_Protein_Tyrosine_Kinase	Signaling_Protein	TEC Protein Tyrosine Kinase|TEC|Tyrosine-Protein Kinase TEC	Expressed in myeloid, B-, and T-cell lineages by human TEC Gene (TEC Tyr Kinase Family), 631-aa 74-kDa TEC Protein Tyrosine Kinase, a non-receptor protein-tyrosine kinase a containing a PH domain, an SH2 domain, and an SH3 domain, is an integral component of T cell signaling in T cell activation and regulation of immune functions. Human TEC is 60% homologous to mouse Tsk/ltk and 57% homologous to human BTK. Beyond the SH3, SH2, and kinase domains, the TEC family homology involves an N-terminal family-specific domain. TEC is associated with myelodysplastic syndrome. (NCI)
C30084	Smooth_Muscle_Myosin_Heavy_Chain-11	Microfilament_Protein	Smooth Muscle Myosin Heavy Chain 11|MYH11|Myosin Heavy Chain, Smooth Muscle Isoform|Myosin, Heavy Polypeptide 11, Smooth Muscle|Myosin, Smooth Muscle, Heavy Chain 11|SMHC|SMMHC	Smooth Muscle Myosin Heavy Chain 11, encoded by the human MYH11 gene belonging to the myosin heavy chain family. This protein is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The pericentric inversion of chromosome 16 produces a protein consisting of the first 165 residues from the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Alternative splicing generates isoforms that are differentially expressed, with ratios changing during muscle cell maturation. Additional splice variants exist. (from LocusLink)
C30085	Muscle_Contraction	Cell_Movement_Process	Muscle Contraction|Muscle Cell Contraction	Thick (myosin) and thin (actin) filaments slide against each other to produce contraction of the muscle cell or fiber. (NCI)
C30086	Myosin_Light_Polypeptide_Kinase	Serine-Threonine_Protein_Kinase	Myosin Light Polypeptide Kinase|EC 2.7.1.117|MLCK|MYLK|MYLK2|Myosin Light Chain Kinase|Myosin Light Chain Kinase, Smooth Muscle and Non-Muscle Isozymes|Myosin light chain kinase 2, skeletal/cardiac muscle|Myosin, Light Polypeptide Kinase	Myosin Light Polypeptide Kinase, encoded by the MYLK gene, is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the other arm of chromosome 3. Seven transcript variants that produce seven isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. (from LocusLink)
C30088	Early_Response_Protein-NAK1	Nuclear_Hormone_Receptor_Superfamily	Nuclear Receptor Subfamily 4, Group A, Member 1|Early Response Protein NAK1|Growth Factor Response Protein 1|Growth Factor-Inducible Nuclear Protein N10|Hormone Receptor|NR4A1|Nuclear Hormone Receptor TR3|Orphan Nuclear Receptor HMR|Steroid Receptor TR3|TR3 Orphan Receptor	Nuclear Receptor Subfamily 4, Group A, Member 1, encoded by the NR4A1 gene, is a member of the steroid-thyroid hormone-retinoid receptor superfamily. Its expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. This protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Three transcript variants encoding two distinct isoforms have been identified for this gene. (from LocusLink)
C30090	snRNP_Structural_Core_Protein	Structural_Protein	snRNP Structural Core Protein|Sm Protein|Small Nuclear Ribonucleoprotein Particle Structural Core Protein	The 4 major small nuclear ribonucleoprotein particles (snRNPs), U1, U2, U4/U6, and U5, are essential components of the eukaryotic pre-mRNA splicing machinery. These snRNPs share 8 proteins which form the snRNP structural core: SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, and SNRPG. These common proteins play an essential role in the biogenesis of the snRNPs. The assembly of the common proteins onto the small nuclear RNA (snRNA) appears to occur in at least 2 steps and involves the formation of RNA-free protein heterooligomers. The common proteins are referred to as Sm proteins because they represent the major targets for the anti-Sm autoantibodies which are diagnostic for SLE. (from OMIM and Swiss-Prot)
C30091	Small_Nuclear_Ribonucleoprotein_Polypeptide-F	snRNP_Structural_Core_Protein	Small Nuclear Ribonucleoprotein Polypeptide F|SNRPF|Sm Protein F|Sm-F|SmF|Sma|snRNP-F	Small Nuclear Ribonucleoprotein Polypeptide F, encoded by the SNRPF gene, belongs to the snRNP Sm proteins family. This nuclear protein is associated with sn-RNP U1, U2, U4/U6 and U5. The 4 major small nuclear ribonucleoprotein particles (snRNPs), U1, U2, U4/U6, and U5, are essential components of the eukaryotic pre-mRNA splicing machinery. These snRNPs share 8 proteins which form the snRNP structural core: SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, and SNRPG. These common proteins play an essential role in the biogenesis of the snRNPs. The assembly of the common proteins onto the small nuclear RNA (snRNA) appears to occur in at least 2 steps and involves the formation of RNA-free protein heterooligomers. The common proteins are referred to as Sm proteins because they represent the major targets for the anti-Sm autoantibodies which are diagnostic for SLE. (from OMIM and Swiss-Prot)
C30092	snRNP_Biogenesis	Biosynthesis	snRNP Biogenesis	The 4 major small nuclear ribonucleoprotein particles (snRNPs), U1, U2, U4/U6, and U5, share 8 proteins which form the snRNP structural core: SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, and SNRPG. These common proteins play an essential role in the biogenesis of the snRNPs. The assembly of the common proteins onto the small nuclear RNA (snRNA) appears to occur in at least 2 steps and involves the formation of RNA-free protein heterooligomers. (from OMIM)
C30093	Transcription_Factor-DP2	Transcription_Factor	Transcription Factor Dp-2|DRTF1|E2F Dimerization Partner 2|TFDP2	Expressed in heart, skeletal muscle, placenta, kidney, brain, lung, and liver, human TFDP2 Gene (E2F/DP Family) encodes alternative isoforms alpha (446-aa, 49-kDa), beta (369-aa, 43-kDa), gamma (370-aa), and delta (385-aa, 48-kDa) of phosphorylated nuclear Transcription Factor Dp-2, which in a heterodimeric complex with E2F family members regulates genes required for G1/S cell-cycle progression, S-phase progression, cell cycle regulation, DNA replication, or apoptosis. TFDP2 binds DNA cooperatively with E2F through the E2 recognition site, TTTCC/GCGC. Interact of DP/E2F with hypophosphorylated RB1, P107, and P130 inhibits the E2F transactivation domain. In mid-to-late G1, phosphorylated RB detaches from DP/E2F rendering E2F transcriptionally active. Viral oncoproteins E1A, T-antigen, and HPV E7 can sequester RB protein, releasing active DP/E2F complex. (NCI)
C30094	Transcription_Factor-E3	Transcription_Factor	Transcription Factor Binding to IGHM Enhancer 3|TFE3|Transcription Factor E3|Transcription Factor for IgH Enhancer	Ubiquitously expressed by human TFE3 Gene (bHLH Family), 743-aa 80-kDa nuclear Transcription Factor Binding to IGHM Enhancer 3 contains an activation domain, leucine zipper, and bHLH domain and binds to the Ig heavy-chain enchancer MUE3 motif and to the USF/MLTF site. Efficient DNA binding requires dimerization with another bHLH protein. TFE3 is involved in papillary renal cell carcinoma through chromosomal translocations t(X;1)(p11.2;q21.2) which involves PRCC; t(X;1)(p11.2;p34) which involves PSF, and Inv(X)(p11.2;q12) which involves NONO.  (NCI)
C30095	Cardiac_Muscle_Contraction	Muscle_Contraction	Cardiac Muscle Contraction	Driven primarily by voltage-gated Ca+2 action potentials originating in sinoatrial pace-maker cells, Cardiac Muscle Contraction involves shortening of the gap junction-linked nonsyncytial striated heart myocytes in the atrial and ventricular chambers that forces movement of the blood through the circulatory system.
C30096	Basal_Transcription_Factor_Gene	Transcription_Factor_Gene	Basal Transcription Factor Gene|General Transcription Factor Gene	Human Basal Transcription Factor Genes encode Basal Transcription Factors, a diverse group of general factors required for transcription of all eukaryotic PolII genes. Initiation of transcription from eukaryotic protein-coding genes is a complex process requiring RNA polymerase II (PolII) and a cadre of transcription factors. The general transcription factors and PolII form a multiprotein complex near the transcription start site by interacting with core promoter elements. The most common core element is the TATA box, typically 25-30 bp upstream of the start site.
C30097	LYL1_Protein	BHLH_Protein	Lymphoblastic Leukemia Derived Sequence 1|LYL1|Lyl-1 Protein	Lymphoblastic Leukemia Derived Sequence 1, encoded by the human LYL1 gene, contains 1 basic helix-loop-helix (bHLH) domain. Efficient DNA binding of this protein requires dimerization with another bHLH protein. This gene is involved in a form of T-cell acute lymphoblastic leukemia (T-ALL) through a chromosomal translocation t(7;9)(q35;p13) which involves LYL1 and T-cell receptor beta chain (TCRB) genes. (from Swiss-Prot)
C30098	Transforming_Growth_Factor_Beta_Receptor-I	Receptor_Serine-Threonine_Kinase	Transforming Growth Factor Beta Receptor I|ALK5|Activin A Receptor Type II-Like Kinase 53kDa|Activin Receptor-Like Kinase 5|SKR4|Serine/Threonine-Protein Kinase Receptor R4|TGF-Beta Receptor Type I|TGF-Beta Type I Receptor|TGFBR1|Transforming Growth Factor Beta Receptor Type I	Expressed in all tissues (most in placenta) by human TGFBR1 Gene (TGFBR Ser/Thr Family), 503-aa 53-kDa (56-kDa precursor) Transforming Growth Factor Beta Receptor I is a type I transmembrane protein receptor for multifunctional cytokine TGFB1 containing a signal peptide, an extracellular Cys-rich region with an N-glycosylation site, a transmembrane region, and a cytoplasmic protein Ser/Thr kinase domain that mediates induction of cell-matrix adhesion genes and regulates cell cycle progression. TGF-beta binds either TGFBR1 or transmembrane Ser/Thr TGF-Beta II receptor, which form an active heterodimeric complex. TGFB stimulation leads to phosphorylation and activation of SMAD2 and SMAD3, which, complexed with SMAD4, accumulate in the nucleus and regulate transcription of target genes. Continuous SMAD nucleocytoplasmic shuttling during TGFB signaling monitors receptor activity. (NCI)
C30099	Transforming_Growth_Factor_Beta_Receptor-III	Receptor_Serine-Threonine_Kinase	Transforming Growth Factor Beta Receptor III|Beta-Glycan|Betaglycan|TGF-Beta Receptor Type III|TGFR3|Transforming Growth Factor Beta Receptor Type III	Encoded by human TGFBR3 Gene, 849-aa 93-kDa (precursor) Transforming Growth Factor Beta Receptor III is a membrane-bound or soluble glycoprotein heavily modified by glycosaminoglycan groups, with regions of similarity to endoglin, and containing a ZP domain. Lacking a recognizable signaling domain, TGFBR3 binds to TGF-Beta and may be a TGFBR and FGFR receptor accessory molecule; it may capture and retain TGF-Beta for presentation to signaling receptors. TGF-beta is a multifunctional cytokine that modulates cell differentiation, cell cycle progression, cellular migration, adhesion, and extracellular matrix production. TGFBR3 can also bind inhibin and function as coreceptor with ActRII; inhibin forms crosslinked complexes with TGFBR3 and ActRII. TGFBR3 also binds beta arrestin 2, which appears to trigger cytoplasmic phosphorylation by TGFBR2. (NCI)
C30100	Protein_Receptor_Tyrosine_Kinase-TIE1	Receptor_Tyrosine_Kinase	Protein Receptor Tyrosine Kinase TIE 1|JTK14|TIE1|Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor Homology Domains|Tyrosine-Protein Kinase Receptor TIE1	Specifically expressed in developing endothelial cells by human TIE Gene (TIE Tyr Kinase Family), 1138-aa 125-kDa (precursor) type I transmembrane Protein Receptor Tyrosine Kinase TIE 1 contains 2 Ig-like C2-type domains, 3 fibronectin type III domains, and 3 EGF-like domains. TIE1 receptor may be involved in multiple protein-protein interactions, possibly including endothelial cell adhesion, blood clotting, and inflammation. TIE1 receptor is important in angiogenesis, particularly endothelial vascular formation. Combinatorial ANG-1 and TIE1 orphan receptor function is critical for right-side venous system development. (NCI)
C30101	Toll-Like_Receptor-1	Cell_Surface_Receptor	Toll-Like Receptor 1|TIL|TLR1|Toll/Interleukin-1 Receptor-Like	Ubiquitously expressed (highest in spleen, ovary, leukocytes, thymus, and small intestine) by human TLR1 Gene (TLR family), 786-aa 90-kDa (precursor) type I transmembrane Toll-Like Receptor 1 contains a TIR domain and 8 LRR repeats and has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR1 binds to the TLR2 extracellular domain and cooperates with TLR2. TLR1 appears to bind MyD88 via their TIR domains, and to TRAF6, leading to NF-Kappa-B activation, cytokine secretion, and inflammatory response. (NCI)
C30102	Toll-Like_Receptor-2	Cell_Surface_Receptor	Toll-Like Receptor 2|TIL4|TLR2|Toll/Interleukin 1 Receptor-Like 4|Toll/Interleukin 1 Receptor-Like Protein 4	Highly expressed in monocytes, bone marrow, lymph node, and spleen by human TLR2 Gene (TLR Family), 784-aa 90-kDa (precursor) type I transmembrane Toll-Like Receptor 2 contains a TIR domain and 14 LRR repeats and has a fundamental role in pathogen recognition and activation of innate immunity. Sharing structural and functional similarities, TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production for effective immunity. With LY96, TLR2 mediates response to microbial lipoproteins and cell wall components. Binding LY96 and TLR6 via the extracellular domains, TLR2 recognizes MALP-2, STF, PSM, and OspA-L with TLR6. TLR2 acts via MyD88 (via their TIR domains) and TRAF6, activating NF-Kappa-B, cytokine secretion, and inflammatory response. TLR2 may promote apoptosis in response to lipoproteins. (NCI)
C30103	Stable	Disease_Clinical_Modifier	Stable	Stable; subject to little fluctuation; showing little if any change.
C30104	Toll-Like_Receptor-3	Cell_Surface_Receptor	Toll-Like Receptor 3|TLR3	Expressed most in placenta, pancreas, and CD11c+ immature dendritic leukocytes by human TLR3 Gene (TLR Family), 904-aa 104-kDa (precursor) type I membrane protein Toll-Like Receptor 3 contains a TIR domain and 22 LRR repeats. Likely involved in host viral defense, TLR3 recognizes viral dsRNA and has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR3 appears to act via MyD88 (TIR interaction) and TRAF6, leading to NF-Kappa-B activation and production of type I interferons. (NCI)
C30105	Toll-Like_Receptor-4	Cell_Surface_Receptor	Toll-Like Receptor 4|TLR4|TOLL|Toll Homologue|hToll	Expressed most in placenta, spleen, and myelomonocytic leukocytes by human TLR4 Gene (TLR Family), isoforms A-D of 96-kDa (precursor) type I membrane protein Toll-Like Receptor 4 contains a TIR domain and 21 LRR repeats. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. As part of the LPS receptor (with CD14 and LY96), TLR4 mediates the immune response to LPS in gram-negative bacteria. Binding to LY96 via the extracellular domain and to MyD88 and TIRAP via their TIR domains, TLR4 acts via MyD88, TIRAP, and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and the inflammatory response. TLR4 Asn-526 and Asn-575 glycosylation seems necessary for the LPS-response. (NCI)
C30106	Toll-Like_Receptor-5	Cell_Surface_Receptor	Toll-Like Receptor 5|TIL3|TLR5|Toll/Interleukin-1 Receptor-Like Protein 3	Highly expressed in ovary and myelomonocytic cells by human TLR5 Gene (TLR Family), 858-aa 98-kDa (precursor) type I membrane protein Toll-Like Receptor 5 contains a TIR domain and 15 LRR repeats. Mediating detection of bacterial flagellin (a virulence factor), TLR5 has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. Likely bound to MyD88 via the TIR domains, TLR5 acts via MyD88 and TRAF6, leading to NF-Kappa-B activation, TNF-alpha production, and the inflammatory response. (NCI)
C30107	Toll-Like_Receptor-6	Cell_Surface_Receptor	Toll-Like Receptor 6|TLR6	Expressed in monocytes, CD11c+ immature dendritic cells, and dermal endothelial cells by human TLR6 Gene (TLR Family), 796-aa 92-kDa (precursor) type I membrane protein Toll-Like Receptor 6 contains a TIR domain and 13 LRR repeats. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. Bound extracellularly to TLR2, TLR6 mediates cellular response to fungi and bacterial lipoproteins MALP-2, STF, PSM, and OspA-L. TLR6 acts via MyD88 (TIR interaction) and TRAF6, leading to NF-kappa-B activation, cytokine secretion, and the inflammatory response. (NCI)
C30108	Toll-Like_Receptor-7	Cell_Surface_Receptor	Toll-Like Receptor 7|TLR7	Expressed in lung, placenta, spleen, brain, stomach, small intestine, and pre-dendritic cells by human TLR7 Gene (TLR Family), 104-aa 121-kDa (precursor) type I membrane protein Toll-Like Receptor 7 contains a TIR domain and 27 LRR repeats. TLR7 has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR7 likely acts via MyD88 (TIR interaction) and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. (NCI)
C30109	Toll-Like_Receptor-8	Cell_Surface_Receptor	Toll-Like Receptor 8|TLR8	Expressed in lung, brain, heart, liver, placenta, monocytes, peripheral leukocytes, and CD11c+ immature dendritic cells by human TLR8 Gene (TLR Family), 1041-aa 120-kDa (precursor) type I membrane protein Toll-Like Receptor 8 contains a TIR domain and 24 LRR repeats. TLR8 has a fundamental role in pathogen recognition and activation of innate immunity to microbial agents. Sharing structural and functional similarities, highly conserved TLRs recognize pathogen-associated molecular patterns expressed on infectious agents and mediate cytokine production necessary for effective immunity. TLR8 likely acts via MyD88 (TIR interaction) and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. (NCI)
C30110	Transmembrane_Protease_Serine-2	Protease	Transmembrane Protease Serine 2|Epitheliasin|TMPRSS2	Expressed in small intestine, prostate, colon, stomach, and salivary gland by human TMPRSS2 Gene (Peptidase S1 Family), 492-aa 54-kDa (precursor) Transmembrane Protease Serine 2 contains a type II transmembrane domain, an LDL-receptor class A domain, a scavenger receptor cysteine-rich (SRCR) domain, and a protease domain. The protease domain is thought to be cleaved, activated, and secreted after autocleavage. (NCI)
C30111	Osteoprotegerin	TNF_Receptor_Family_Protein	Tumor Necrosis Factor Receptor Superfamily Member 11B|Osteoclastogenesis Inhibitory Factor|Osteoprotegerin|TNFRSF11B	Widely expressed by estrogen- and glucocorticoid-regulated human TNFRSF11B Gene (TNFR Family), 401-aa 46-kDa (precursor) N-glycosylated homodimeric secreted Tumor Necrosis Factor Receptor Superfamily Member 11B contains a blocked N-terminus, 4 TNFR-Cys repeats, 2 death domains, and sialic acid residues. TNFRSF11B acts as a regulator of bone homeostasis and osteoclast development. A decoy receptor for RANKL (TNFSF11/OPGL), TNFRSF11B inhibits activation of osteoclasts (osteoclastogenesis) and promotes osteoclast apoptosis. TNFRSF11B may also act as decoy receptor for TRAIL, protecting against apoptosis and inhibition of osteoclastogenesis. (NCI)
C30112	FAS_Ligand_Decoy_Receptor	TNF_Receptor_Family_Protein	Decoy Receptor for FAS Ligand|DCR3|Decoy Receptor 3|M68|TNFRSF6B|TR6	Expressed in stomach, spinal cord, lymph node, trachea, spleen, colon and lung, human TNFRSF6B Gene (TNFR Family) encodes isoforms of 300-aa 33-kDa (precursor) secreted Decoy Receptor for FAS Ligand, a decoy receptor containing 4 TNFR-Cys repeats that protects against apoptosis by competing with death receptors for cytotoxic ligands TNFS14 and FasL. (NCI)
C30113	Osteoprotegerin_Ligand	Tumor_Necrosis_Factor_Family_Protein	Tumor Necrosis Factor Ligand Superfamily Member 11|ODF|OPGL|Osteoclast Differentiation Factor|Osteoprotegerin Ligand|RANKL|Receptor Activator of Nuclear Factor Kappa B Ligand|TNF-Related Activation-Induced Cytokine|TNFSF11|TRANCE	Most highly expressed in lymph nodes and upregulated by TCR stimulation, human TNFSF11 Gene (TNF Family) encodes alternative isoforms of 35-kDa (precursor) homotrimeric cytokine Tumor Necrosis Factor Ligand Superfamily Member 11, which binds as an osteoclast activation and differentiation ligand to TNFRSF11B/OPG and to TNFRSF11A/RANK. Isoforms 1 and 3 are type II membrane proteins; isoform 2 is secreted. A soluble form of isoform 1 likely derives from proteolytic processing by ADAM17. TNFSF11 activates antiapoptotic kinase AKT/PKB through a SRC kinase/TRAF6 signaling complex and augments or regulates dendritic cell stimulation of naive T-cell proliferation. (NCI)
C30114	Non-Receptor_Tyrosine_Kinase-1	Signaling_Protein	Non-Receptor Tyrosine Kinase 1|CD38-Negative Kinase|TNK1	Expressed in prostate, testis, ovary, small intestine, and colon by human TNK1 Gene, 666-aa 72-kDa Non-Receptor Tyrosine Kinase 1 contains a putative N-terminal phosphotyrosine-binding domain, a tyrosine kinase domain, a putative SH3 domain, and a Pro-rich C-terminus containing SH3-binding motifs. The kinase domain includes an ATP-binding site and many conserved tyrosine kinase features. TNK1 shares highest homology with ACK, especially in the kinase and putative SH3 domains. Like SRC and JAK family kinases, TNK1 mediates intracellular signaling downstream of receptor activation. (NCI)
C30115	Toll-Interacting_Protein	Adaptor_Signaling_Protein	Toll-Interacting Protein|TOLLIP|TOLLIP Protein	Encoded by human TOLLIP Gene, 274-aa 30-kDa oligomeric Toll-Interacting Protein, containing a CUE domain, is involved in IL-1 and Toll-like receptor signaling pathways. TOLLIP binds to TLR2 and TLR4/MD2 complex via its C-terminus. Complexed with Ser/Thr kinase IRAK in unstimulated cells, TOLLIP inhibits IRAK phosphorylation and kinase activity. Upon IL-1 signaling, TOLLIP interacts with the IL-1RacP TIR domain in the activated receptor complex (IL-1RI/IL-1RacP/MyD88), recruiting IRAK to the complex. MyD88 triggers IRAK1 autophosphorylation and IRAK1 dissociation. (NCI)
C30116	Tumor_Protein-D52	Protein_with_Unknown_or_Unclassified_Function	Tumor Protein D52|D52|N8 Protein|TPD52	Expressed in several tissues by human TPD52 Gene (TPD52 Family), 184-aa 20-kDa Tumor Protein D52 exhibits a potential glycosylation site, several potential phosphorylation sites, and homology to N-type calcium channels. TPD52 forms homodimers, or heterodimers with other family members; D52, D53, and D54 share homology, including a coiled-coil domain indicative of protein-protein interactions. D52 may be involved in calcium-mediated signal transduction and cell proliferation. (NCI)
C30117	Tumor_Protein-D52-Like-1_Protein	Protein_with_Unknown_or_Unclassified_Function	Tumor Protein D52-Like 1|D52-Like 1|D53|TPD52L1|Tumor Protein D53|hD53	Expressed in kidney and skin by human TPD52L1 Gene (TPD52 Family), 204-aa 22-kDa Tumor Protein D52-Like 1 exhibits 52% identity to D52, a coiled-coil domain, and PEST domains. D52, D53, and D54 share significant homology, including a coiled-coil domain indicative of protein-protein interactions. TPD52L1 forms homodimers, or heterodimers with other family members. Like D52, TPD52L1 may be involved in calcium-mediated signal transduction and cell proliferation.
C30118	Phosphoprotein_Associated_with_GEMs	Adaptor_Signaling_Protein	Phosphoprotein Associated with GEMs|PAG|Phosphoprotein Associated with Glycosphingolipid-Enriched Microdomains	Encoded by human PAG Gene, ubiquitous 432-aa 47-kDa Phosphoprotein Associated with GEMs is a type III plasma transmembrane adaptor protein located predominantly in membrane rafts (GEMs), associated with FYN and CSK tyrosine kinase, and thought to be involved in T cell activation and immunoreceptor signal transduction. PAG contains a 16-aa extracellular domain, a transmembrane domain, a putative palmitoylation site, and a 397-aa cytoplasmic tail with 9 potential tyrosine phosphorylation sites, ITAM-like motifs, and multiple putative casein kinase II and protein kinase C phosphorylation sites. Two Pro-rich sequences may bind to SH3 domains. PAG recruits CSK to the plasma membrane, independent of FYN. After T-cell activation, association with CSK, but not FYN, decreases. PAG/CSK may increase the signaling threshold for initiating an immune response, keeping lymphocytes in a resting state. (NCI)
C30119	p21-Activated_Kinase-6	Serine-Threonine_Protein_Kinase	p21-Activated Kinase 6|EC 2.7.1.-|PAK-5|PAK-6|PAK6|Serine/Threonine-Protein Kinase PAK 6|p21(CDKN1A)-Activated Kinase 6|p21-Activated Protein Kinase 6	p21-Activated Kinase 6, encoded by the PAK6 gene, shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. p21-Activated Kinase 6 was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. The PAK6 gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. (from LocusLink)
C30120	Apoptosis_Response_Protein	Transcription_Repressor_Corepressor	Apoptosis Response Protein|Hypothetical Protein|PAWR|PRKC, Apoptosis, WT1, Regulator|Prostate Apoptosis Response Protein 4|Transcriptional Repressor PAR4|WT1-Interacting Protein	Apoptosis Response Protein, encoded by the PAWR gene, is a WT1-interacting protein that itself functions as a transcriptional repressor. It contains a putative leucine zipper domain which interacts with the zinc finger DNA binding domain of WT1. Apoptosis Response Protein is specifically upregulated during apoptosis of prostate cells. (from LocusLink)
C30121	Smooth_Endoplasmic_Reticulum	Endoplasmic_Reticulum	Smooth Endoplasmic Reticulum|Smooth-Surfaced Endoplasmic Reticulum|sER	An internal membrane structure of the eukaryotic cell. Biochemically similar to the rough endoplasmic reticulum, but lacks the ribosome binding function. Tends to be tubular rather than sheet like, may be separate from the rough endoplasmic reticulum or may be an extension of it. Abundant in cells concerned with lipid metabolism and proliferates in hepatocytes when animals are challenged with lipophilic drugs. (On-line Medical Dictionary)
C30122	Tax_Interaction_Protein-40	Ligand_Binding_Protein	Tax Interaction Protein 40|PAR-6|PAR-6 Alpha|PAR-6A|PAR6C|PARD6A|Partitioning Defective-6 Homolog Alpha|TIP-40|Tax-Interaction Protein 40 Par-6 (Partitioning Defective 6, C.elegans) Homolog Alpha	Tax Interaction Protein 40, encoded by the PARD6A gene, belongs to the PAR6 family. It is an adapter protein involved in asymetrical cell division and cell polarization processes. It is probably involved in the formation of epithelial tight junctions. Its association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. (from Swiss-Prot)
C30123	Paired_Box_Protein_Pax-3	Transcription_Coactivator	Paired Box Protein Pax-3|PAX3|PAX3/FKHR Fusion Gene|Paired Box Homeotic Gene 3|Paired Domain Gene 3|Paired Domain Gene HuP2	Paired Box Protein Pax-3, encoded by the PAX3 gene, is a member of the paired box (PAX) family of transcription factors. Members of the PAX family typically contain a paired box domain and a paired-type homeodomain. These genes play critical roles during fetal development. Mutations in paired box gene 3 are associated with Waardenburg syndrome, craniofacial-deafness-hand syndrome, and alveolar rhabdomyosarcoma. The translocation t(2;13)(q35;q14), which represents a fusion between PAX3 and the forkhead gene, is a frequent finding in alveolar rhabdomyosarcoma. Alternative splicing results in transcripts encoding isoforms with different C-termini. (from LocusLink)
C30124	Paired_Box-5_Protein	Transcription_Coactivator	Paired Box 5|B-Cell Lineage Specific Activator Protein|B-Cell Specific Transcription Factor|BSAP|PAX5|Paired Box Homeotic Gene 5|Paired Box Protein Pax-5	Paired Box 5, encoded by the PAX5 gene, is a member of the paired box (PAX) family of transcription factors. Paired Box 5 is expressed at early stages of B-cell differentiation. Its expression is also detected in developing CNS and testis. Paired Box 5 may not only play an important role in B-cell differentiation, but also in neural development and spermatogenesis. This gene is located in chromosome 9p13 region, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoters. Deregulation of PAX5 gene transcription may contribute to the pathogenesis of these lymphomas. (from LocusLink)
C30125	TNF_Receptor-Associated_Factor-6	Adaptor_Signaling_Protein	TNF Receptor-Associated Factor 6|Interleukin 1 Signal Transducer|TRAF6	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas, human TRAF6 Gene (TRAF Family) encodes 522-aa 60-kDa oligomeric adapter protein and signal transducer TNF Receptor-Associated Factor 6, containing a MATH domain, a RING-type zinc finger, 2 TRAF-type zinc fingers, and a coiled coil domain that mediates homo- and hetero-oligomerization. The MATH/TRAF domain binds to receptor cytoplasmic domains. In mediating TNFR and Toll/IL-1 family signal transduction to diverse pathways, TRAF6 interacts with TNFRSF5, -11A, -11B, -16 and -17, SRC, PKC zeta, IRAK1, -2, and -3, RIPK2, MAP3K1, -5, and -14, CSK, TRIP, TRAF, TTRAP, PELI1, PELI2, and PELI3. TRAF6 activates IKK in the NF-kappa B pathway in response to proinflammatory cytokines and is involved in the IL-1 signaling pathway via MYD88 and IRAK kinases. (NCI)
C30126	Taxol_Resistance_Associated_Protein-3	Protein_with_Unknown_or_Unclassified_Function	Taxol Resistance Associated Protein 3|TRAG3	Expressed in kidney by human TRAG3 Gene, alternative isoforms 127-aa, 14.5-kDa TRAG-3L and 110-aa TRAG-3S of Taxol Resistance Associated Protein 3 are associated with chemotherapy drug-resistance. (NCI)
C30127	Multiple_Membrane_Spanning_Receptor-TRC8	Ligase	Multiple Membrane Spanning Receptor TRC8|Patched Related Protein TRC8|RNF139|Ring Finger 139|TRC8	Encoded by human TRC8 Gene, Multiple Membrane Spanning Receptor TRC8 is a multi-membrane spanning ER protein containing a RING-H2 zinc finger with ubiquitin ligase activity. TRC8 may interact with tumor suppressor protein VHL as well as with COPS5/JAB1, responsible for degradation of tumor suppressor CDKN1B/p27KIP. (NCI)
C30128	T-Cell_Receptor_Interacting_Molecule	Adaptor_Signaling_Protein	T-Cell Receptor Interacting Molecule|TCR-Interacting Molecule|TCRIM|TRIM	Expressed in T cells (not B cells or monocytes) of the thymus, spleen, lymph nodes, and peripheral leukocytes by human TRIM Gene, 186-aa 29/30-kD disulfide-linked dimeric type III transmembrane adaptor phosphoprotein T-Cell Receptor Interacting Molecule contains an 8-aa extracellular domain (includes a Cys residue), a 19-aa transmembrane region and an intracellular domain with 4 potential phosphorylation sites likely involved in SH2-mediated interactions with signaling proteins. Associated with CD3E and CD3Z, TRIM modulates the TCR-CD3 complex in T lymphocytes. After T-cell activation, TRIM is tyrosine phosphorylated by Src kinases and associates with PIK3R1. (NCI)
C30129	Triple_Functional_Domain_Protein	Guanine_Nucleotide_Exchange_Factor	Triple Functional Domain Protein|PTPRF Interacting Protein|TRIO	Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney, and lung by human TRIO Gene (Ser/Thr Kinase Family), 3038-aa 342-kDa serine phosphorylated Triple Functional Domain Protein contains a Ser/Thr kinase domain, 2 DH domains, a CRAL-TRIO domain, an Ig-like C2-type domain, 2 PH domains, an SH3 domain, and 4 spectrin repeats. The N-terminal DBL(DH)/GEF domain catalyzes RAC1 GDP/GTP exchange, leading to JUN kinase activation and membrane ruffling. The second DBL(DH)/GEF domain catalyzes RHOA GDP/GTP exchange, inducing stress fiber formation. Interacting with the cytoplasmic region of LAR tyrosine phosphatase, TRIO may coordinate cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth. (NCI)
C30130	Thyroid_Hormone_Receptor_Interactor-10	Signaling_Protein	Thyroid Hormone Receptor Interactor 10|CDC42-Interacting Protein 4|TRIP10|Thyroid Receptor Interacting Protein 10	Expressed in skeletal muscle, heart, placenta, pancreas, lung, liver, kidney, and brain by human TRIP10 Gene, 545-aa 63-kDa Thyroid Hormone Receptor Interactor 10 contains an SH3 domain, an FCH domain, and similarity to the non-kinase domains of FER and FES/FPS tyrosine kinases. Likely involved in CDC42 and WASP-dependent signal transduction, TRIP10 binds to activated CDC42 and may link CDC42 signaling with regulation of the actin cytoskeleton. TRIP10 specifically interacts (TH-dependent) with the ligand-binding domain of TR. (NCI)
C30131	MLSN1_and_TRP-Related_Protein	Protein_with_Unknown_or_Unclassified_Function	MLSN1 and TRP-Related Protein|LTRPC5|Long Transient Receptor Potential Channel 5|MTR1|TRPM5|Transient Receptor Potential Cation Channel, Subfamily M, Member 5	Expressed in various tissues by human TRPM5 Gene, Transient Receptor Potential Cation Channel Subfamily M Member 5 is related to the transient receptor potential (trp) protein TRPC1 and potentially involved in regulation of cellular Ca(2+) influx. The putative open reading frame encodes alternative 872-aa or 1,165-aa proteins, each with several predicted membrane-spanning domains. Mouse Trpm5 functions as a cationic channel that is gated when internal calcium stores are depleted. (NCI)
C30132	Transformation-Transcription_Domain-Associated_Protein	Transcription_Coactivator	Transformation/Transcription Domain-Associated Protein|350/400 kDa PCAF-Associated Factor|PAF350/400|STAF40|TRA1 Homologue|TRRAP	Encoded by human TRRAP Gene (TRA1 Kinase Family), 3859-aa 438-kDa and 3830-aa isoforms of adapter protein Transformation/Transcription Domain-Associated Protein, containing 2 TPR repeats, are a component of multiprotein chromatin PCAF histone acetylase complex, TFTC-HAT complex, STAGA complex, and TIP60 HAT and BAF53 complexes, which acetylate histone H4/H2A in nucleosomes. Required for p53-, E2F1- and E2F4-mediated transcription activation, TRRAP interacts with GCN5L2, TP53, MYC, E2F1, and E2F4 transcription factors; it probably links E1A, MYC, and E2F1 to HAT complexes allowing transcription activation. Lacking kinase catalytic motifs and activity, the PI3K/PI4K domain is required for recruitment of HAT complexes and MYC-dependent transactivation. Cell cycle TRRAP is probably not required in transcription activation following histone acetylation. (NCI)
C30133	Thyroid_Stimulating_Hormone_Receptor	G_Protein-Coupled_Receptor	Thyroid Stimulating Hormone Receptor|TSHR|Thyrotropin Receptor	Encoded by human TSHR Gene (FSH/LSH/TSH GPCR1 Family), alternative long and short isoforms of integral membrane protein Thyroid Stimulating Hormone Receptor act as a Thyrotropin receptor, containing 6 LRR repeats, whose activity is mediated by adenylate cyclase-activating G proteins and controls thyroid cell metabolism. TSHR also acts as a thyrostimulin receptor (GPA2+GPB5). TSHR defects cause hypothyroidism, Graves' disease, euthyroidism or papillary and follicular thyroid neoplasms. (NCI)
C30134	Testis-Specific_Kinase_Substrate	Protein_with_Unknown_or_Unclassified_Function	Testis-Specific Kinase Substrate|TSKS|TSKS1|Testis Specific Serine/Threonine Kinase Substrate	Greater than 24-kb, 11-exon human TSKS Gene encodes 592-aa 65-kDa Testis-Specific Kinase Substrate, expressed highest in the testis. With 73% amino acid identity to mouse Tsks, TSKS has an N-terminal signal peptide, several potential phosphorylation and glycosylation sites, but no transmembrane region. TSKS may play a role in testicular physiology, spermatogenesis or spermiogenesis. (NCI)
C30135	Thymic_Stromal_Lymphopoietin	Cytokine	Thymic Stromal Lymphopoietin|TSLP|Thymic Stromal Lymphopoietin Protein TSLP	Widely expressed in heart, liver, testis, prostate, smooth muscle, keratinocytes, epithelia, and lung fibroblasts by human TSLP Gene (B Cell-Stimulating Cytokine Family), 159-aa 18-kDa hemopoietic cytokine Thymic Stromal Lymphopoietin contains a 28-aa signal sequence, 6 conserved cysteines, 2 N-glycosylation sites, and 7 basic C-terminal amino acids (KKRRKRK). TSLP signals through a heterodimeric TSLPR(CRLF2)/IL7R Alpha receptor. Like IL7, TSLP stimulates STAT5 phosphorylation. Dendritic cells (DC) and monocytes coexpress IL7R and TSLPR. TSLP induces release of T cell-attracting chemokines from monocytes, expression of cytokines and costimulatory molecules in DCs, enhances DC maturation, and induces T-cell proliferation. TSLP also inhibits apoptosis in some cells. (NCI)
C30136	Interferon_Alfa-N3	Therapeutic_Interferon_Alfa	Interferon Alfa-N3|Alfa-N3 Interferon|Alferon N|Altemol	A formulated therapeutic analog of the endogenous alpha interferon containing multiple interferon species with antiviral and antitumor properties.  Interferons bind to specific cell-surface receptors, leading to the transcription and translation of genes with an interferon-specific response element, thereby inducing: antiviral effects (the most important being inhibition of viral protein synthesis); antiproliferative effects (including inhibition of cellular growth and alteration of cellular differentiation); anticancer effects (including interference with oncogene expression); and immune-modulating effects (including activation of natural killer cells, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04)
C30137	Paired_Box_Protein_Pax-7	Transcription_Coactivator	Paired Box Protein Pax-7|HUP1|PAX7|Paired Box Gene 7|Paired Box Homeotic Gene 7|Paired Domain Gene 7|Paired Domain Gene HuP1	Paired Box Protein Pax-7, encoded by the PAX7 gene, is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain. These genes play critical roles during fetal development and cancer growth. The specific function of Paired Box Protein Pax-7 is unknown but speculated to involve tumor suppression since fusion of this gene with a forkhead domain family member has been associated with alveolar rhabdomyosarcoma. Alternative splicing in this gene has produced two known products but the biological significance of the variants is unknown. (from LocusLink)
C30138	Pre-B-Cell_Colony-Enhancing_Factor	Cytokine	Pre-B-Cell Colony-Enhancing Factor|PBEF|Pre-B Cell Enhancing Factor	Pre-B-Cell Colony-Enhancing Factor, encoded by the PBEF gene, is a cytokine that acts on early B-lineage precursor cells by enhancing the effect of IL-7 and SCF on pre-B-cell colony formation. This protein is secreted and expressed in large amounts in bone marrow, liver tissue, and muscle. It is also present in heart, placenta, lung, and kidney tissues. (from LocusLink)
C30139	Pre-B-Cell_Leukemia_Transcription_Factor-3	Ligand_Binding_Protein	Pre-B-Cell Leukemia Transcription Factor 3|Homeobox Protein PBX3|PBX3	Pre-B-Cell Leukemia Transcription Factor 3 is encoded by the PBX3 gene. This protein is a transcriptional activator that binds the sequence 5'-ATCAATCAA-3'. Four alternative products result from alternative splicing. (from LocusLink)
C30140	Extremities	Anatomic_Sites	Extremities|Limbs|Non-Trunk	Body limbs, consisting of right upper and lower (arm and leg) and left upper and lower (arm and leg).
C30141	Constitutional_Finding	Retired_Concepts	Constitutional Finding|Constitutional Symptom	Systemic findings reflective of the basic human structure and function, such as temperature, energy/fatigue, and weight.
C30142	Transfusion_History	Personal_Medical_History	Transfusion History	An account of all experiences related to the receipt of blood, WBC, platelets, and/or other blood components.
C30143	Lerisetron	Antiemetic_Agent	Lerisetron|1-Phenyl-Methyl-2-Piperazinyl-1H-Benzimidazole Hydrochloride|F-0930-RS2|lerisetron	A drug that prevents or reduces nausea and vomiting.
C30144	Human_Achaete-Scute_Homolog-1_Protein	Retired_Concepts	Human Achaete-Scute Homolog 1 Protein|ACSL1|ASH1|Mammalian Achaete-Scute Homolog 1
C30145	Testis-Specific_Y-Encoded_Protein	Protein_with_Unknown_or_Unclassified_Function	Testis-Specific Y-Encoded Protein|TSPY|Testis Specific Protein, Y-Linked	Likely up-regulated by androgen and expressed in spermatogonia and spermatocytes by human TSPY Gene, 308-aa 35-kDa phosphorylated cytoplasmic Testis-Specific Y-Encoded Protein may be involved in sperm differentiation and proliferation. (NCI)
C30146	Tetratricopeptide_Repeat_Protein-4	Protein_with_Unknown_or_Unclassified_Function	Tetratricopeptide Repeat Protein 4|My044 Protein|TTC4|Tetratricopeptide Repeat Domain 4 Protein	Widely expressed by human TTC4 Gene, 387-aa 44-kDa Tetratricopeptide Repeat Protein 4 contains a coiled-coil domain and 4 repeats of the 34-amino acid tetratricopeptide repeat (TPR) motif that may mediate protein-protein or protein-membrane interactions. (NCI)
C30147	TTK_Protein_Kinase	Cell_Cycle_Protein	TTK Protein Kinase|Dual Specificity Protein Kinase TTK|ESK|ESK Homologue|MPS1L1|Monopolar Spindle 1-Like 1|PYT|Phosphotyrosine-Picked Threonine Kinase|TTK	Expressed as a 4-kb mRNA in proliferating cells by human TTK Gene (Ser/Thr Kinase Family), 841-aa 95-kDa TTK Protein Kinase is a likely dual-specificity kinase since it phosphorylates proteins on tyrosine as well as serine and threonine. TTK is probably associated with kinetochore or centrosome function in cell proliferation. Kinetochore-associated Mps1 kinase (Xenopus) is necessary to establish and maintain the mitotic checkpoint. Required for kinetochore recruitment and retention of active CENPE, Mps1 is necessary for Mad1 and Mad2 kinetochore association and inhibition of the Anaphase-Promoting Complex/Cyclosome. Mps1 (mouse), a Cdk2 substrate, regulates centrosome duplication jointly with Cdk2. By regulating Mps1 S phase stability, Cdk2 promotes centrosome duplication by Mps1. (NCI)
C30148	TYRO3_Protein_Tyrosine_Kinase	Protein_Tyrosine_Kinase	TYRO3 Protein Tyrosine Kinase|Protein Tyrosine Kinase 3|Protein-Tyrosine Kinase BYK|SEA-Related Receptor Tyrosine Kinase|TYRO3|Tyrosine-Protein Kinase DTK|Tyrosine-Protein Kinase RSE|Tyrosine-Protein Kinase Receptor TYRO3|Tyrosine-Protein Kinase SKY	Widely expressed (abundant in brain) by human TYRO3 Gene (AXL/UFO Tyr Kinase Family), 890-aa 97-kDa (precursor) type I membrane protein TYRO3 Protein Tyrosine Kinase is a putative receptor tyrosine kinase that may be involved in cell adhesion in the central nervous system and contains 2 Ig-like C2-type domains and 2 fibronectin type III domains. (NCI)
C30149	TYRO_Protein_Tyrosine_Kinase_Binding_Protein	Immunoprotein	TYRO Protein Tyrosine Kinase Binding Protein|DNAX-Activation Protein 12|TYROBP	Encoded by human TYROBP Gene, 113-aa 12-kDa (precursor) disulfide-linked homodimeric Tyr-phosphorylated TYRO Protein Tyrosine Kinase Binding Protein is a type I transmembrane polypeptide containing a cytoplasmic ITAM motif that may act as an activating signal transduction element in bone modeling, brain myelination, and inflammation. TYROBP associates with KIR family membrane glycoproteins without a cytoplasmic ITIM; KIR/TYROBP complexes promote cellular activation. TYROBP interacts with SIRPB1 and may bind TCR zeta chain-associated ZAP-70 kinase and SYK tyrosine kinase. (NCI)
C30150	Ubiquitin-Conjugating_Enzyme-E2D2	Ligase	Ubiquitin-Conjugating Enzyme E2D 2|E2(17)KB 2|UBC4/5|UBE2D2|Ubiquitin Carrier Protein|Ubiquitin-Conjugating Enzyme E2-17 kDa 2|Ubiquitin-Protein Ligase	Encoded by human UBE2D2 Gene (E2 Ubiquitin-Conjugating Enzyme Family), 147-aa 16.7-kDa Ubiquitin-Conjugating Enzyme E2D 2 targets selective degradation of short-lived and abnormal proteins, such as E6/E6-AP-induced p53 ubiquitination, through covalent attachment of ubiquitin, the second step of ubiquitin conjugation. UBE2D2 interacts with the SCF/E3 ubiquitin ligase complex. Ubiquitination involves E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. (NCI)
C30151	UNC-13_Homolog-B_Protein	Regulatory_Protein	UNC-13 Homolog B|Munc13 Homolog|UNC-13-Like|UNC13	Encoded by human UNC13 Gene, 1591-aa UNC-13 Homolog B contains 3 C2 domains, a C1 DAG-binding domain, and highly conserved N- and C-terminal similarity to rat Munc13 homologues. UNC13 is a putative DAG receptor and may act in a PKC-independent DAG-activated apoptosis pathway. UNC13 also appears to be a presynaptic protein that promotes synaptic vesicle priming by acting through syntaxin. Post-docking synaptic vesicle exocytosis priming requires SNARE complex formation. The default closed syntaxin configuration is incompatible with SNARE formation; the N-terminus binds the SNARE motif and occludes SNARE protein interactions. UNC13 binding to the syntaxin N-terminus may promote an open syntaxin configuration and prime synaptic vesicles for fusion. (NCI)
C30152	WD_Repeat_Domain_Protein-22	Protein_with_Unknown_or_Unclassified_Function	WD Repeat Domain Protein 22|BCRG2|BCRP2|Breakpoint Cluster Region Protein 2|WD Repeat-Containing Protein 22|WDR22	Widely expressed by human WDR22 Gene, the function of WD Repeat Domain Protein 22 is unknown. (NCI)
C30153	C_Motif_Chemokine_Ligand-2	Gamma_Chemokine	Chemokine (C Motif) Ligand 2|Cytokine SCM-1 Beta|SCM1B|SCYC2|Small Inducible Cytokine Subfamily C Member 2|XC Chemokine Ligand 2|XCL2	Expressed, like XCL1, in activated T cells (low levels in unstimulated cells) by human XCL2 Gene (Intercrine Gamma Family), 114-aa 12.5-kDa (precursor) secreted Chemokine (C Motif) Ligand 2 is most homologous to CCL8 and CCL3 chemokines, but lacks the first and third cysteines characteristic of CC and CXC chemokines and is chemotactic for lymphocytes, but not for monocytes or neutrophils. XCL2 differs from XCL1 (a separate gene product) by only 2 amino acids; XCL2 encodes His7 and Arg8 (mature protein) instead of Asp and Lys as in XCL1. XCL2 induces migration of cells expressing XCR1. Small (8-14 kD), mostly basic, chemokines interact with 7-transmembrane G protein-coupled receptors and regulate cell trafficking of leukocytes, as well as development, homeostasis, and immune system function. (NCI)
C30154	GH1_Gene	hGH_Gene	GH1 Gene|GH1|GHN|Growth Hormone 1 Gene|hGHN	Expressed in the anterior lobe of the pituitary gland under hypothalamic control, human GH1 Gene (Somatotropin/Prolactin Family) encodes Growth Hormone, a small secreted peptide hormone that affects gene expression, metabolism, and growth control. Due to alternative splicing, differential posttranslational modifications, optional binding to GHBP or alpha2-macroglobulin, and potential proteolytic processing, circulating GH shows great heterogeneity as a disulfide-linked or non-covalently associated monomer, dimer, trimer, tetramer, or pentamer in homopolymeric and heteropolymeric combinations. GH stimulates the liver and other tissues to secrete IGF-1. GH stimulates amino acid uptake and protein synthesis in muscle and other tissues and stimulates differentiation and proliferation of myoblasts. GH also stimulates mitosis, cell growth, and differentiation of other cell types. (NCI)
C30155	_17q24_2	Chromosome_Band	17q24.2	A chromosome band present on 17q
C30156	ADA_Gene	Hydrolase_Gene	ADA Gene|Adenosine Deaminase Gene	Adenosine deaminase catalyzes the hydrolysis of adenosine to inosine. ADA deficiency causes one form of severe combined immunodeficiency disease (SCID), in which there is dysfunction of both B and T lymphocytes with impaired cellular immunity and decreased production of immunoglobulins. (LocusLink)
C30157	_1p36_23-p35_1	Chromosome_Band	1p36.23-p35.1	A chromosome band present on 1p
C30158	_20q12-q13_11	Chromosome_Band	20q12-q13.11	A chromosome band present on 20q
C30159	Activated_RNA_Polymerase_II_Transcription_Cofactor-4	Transcription_Coactivator	Activated RNA Polymerase II Transcription Cofactor 4|Activated RNA Polymerase II Transcriptional Coactivator p15|PC4|Positive Cofactor 4|p14	Activated RNA Polymerase II Transcription Cofactor 4, encoded by the PC4 gene, is a general transcriptional coactivator for RNA polymerase II. This protein mediates transcriptional activation of class II genes. It is a single-stranded DNA-binding protein that functions through its interaction with TAFs. (from OMIM, LocusLink)
C30160	PCTAIRE_Protein_Kinase-1	Serine-Threonine_Protein_Kinase	PCTAIRE Protein Kinase 1|EC 2.7.1.-|PCTK1|Serine/Threonine-Protein Kinase|Serine/Threonine-Protein Kinase PCTAIRE-1	PCTAIRE Protein Kinase 1, encoded by the PCTK1 gene, belongs to the cdc2/cdkx subfamily of the ser/thr family of protein kinases. This protein may play a role in signal transduction cascades in terminally differentiated cells. The PCTK1 gene is thought to escape X inactivation. There are three alternatively spliced transcript variants described for this gene. (from LocusLink)
C30161	Phosducin	Signaling_Protein	Phosducin|33kDa Phototransducing Protein|G Beta Gamma Binding Protein|MEKA Protein|PDC|PHD|Phosducin-Like Orphan Protein|Phosducin-Like Protein	Phosducin, encoded by the PDC gene, is a phosphoprotein that is located in the outer and inner segments of the rod cells in the retina. This protein may participate in the regulation of visual phototransduction or in the integration of photoreceptor metabolism. It modulates the phototransduction cascade by interacting with the beta and gamma subunits of the retinal G-protein transducin. This gene is a potential candidate gene for retinitis pigmentosa and Usher syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. (from LocusLink)
C30162	Platelet-Derived_Growth_Factor_Alpha	Platelet-Derived_Growth_Factor	Platelet-Derived Growth Factor Alpha|PDGF A-Chain|PDGF-1|PDGFA|Platelet-Derived Growth Factor A Chain|Platelet-Derived Growth Factor Alpha Polypeptide	Expressed in platelets as 2 alternative isoforms by human PDGFA Gene (PDGF/VEGF Family), Platelet-Derived Growth Factor Alpha is a mitogenic factor for mesenchymal cells characterized by a motif of eight cysteines and released by platelets upon wounding to stimulate adjacent cell growth. PDGFA can exist as either antiparallel disulfide-linked homodimers or heterodimers with Platelet-Derived Growth Factor Beta. A long PDGFA isoform contains a basic insert that acts as a cell retention signal. A-A, B-B, and A-B, dimers can bind to PDGF receptor and elicit a variety of cellular responses. A and B homodimers are implicated in transformation processes. (NCI)
C30163	Platelet-Derived_Growth_Factor_Receptor_Alpha_Polypeptide	Receptor_Tyrosine_Kinase	Platelet-Derived Growth Factor Receptor Alpha Polypeptide|Alpha Platelet-Derived Growth Factor Receptor|CD140a Antigen|EC 2.7.1.112|PDGF-R-Alpha|PDGFRA	Platelet-Derived Growth Factor Receptor, Alpha Polypeptide, encoded by the PDGFRA gene, is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes. (from LocusLink)
C30164	Platelet-Derived_Growth_Factor_Receptor_Beta_Polypeptide	Receptor_Tyrosine_Kinase	Platelet-Derived Growth Factor Receptor Beta Polypeptide|Beta Platelet-Derived Growth Factor Receptor|CD140b Antigen|EC 2.7.1.112|PDGF-R-Beta|PDGFRB	Platelet-Derived Growth Factor Receptor, Beta Polypeptide, encoded by the PDGFRB gene, is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETS, leukemia gene, results in chronic myelomonocytic leukemia. (from LocusLink)
C30165	Platelet-Derived_Growth_Factor_Receptor-Like_Protein	Protein_with_Unknown_or_Unclassified_Function	Platelet-Derived Growth Factor Receptor-Like Protein|PDGFRL|Platelet-Derived Growth Factor Receptor-Like|Platelet-Derived Growth Factor-Beta-Like Tumor Suppressor	Platelet-Derived Growth Factor Receptor-Like Protein, encoded by the PDGFRL gene, has significant sequence similarity to the ligand binding domain of platelet-derived growth factor receptor beta. Mutations in this gene, or deletion of a chromosomal segment containing this gene, are associated with sporadic hepatocellular carcinomas, colorectal cancers, and non-small cell lung cancers. This suggests this gene product may function as a tumor suppressor. (from LocusLink)
C30166	PKB_Kinase	Serine-Threonine_Protein_Kinase	3-Phosphoinositide Dependent Protein Kinase-1|EC 2.7.1.37|PDPK1|PKB Kinase|hPDK1	3-Phosphoinositide Dependent Protein Kinase-1, encoded by the PDPK1 gene, belongs to the Ser/Thr family of protein kinases. This protein phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, p70S6K and p90S6K/RSK. It may play a general role in signaling processes and in development (by similarity). It becomes cytoplasmic and membrane-associated after cell stimulation leading to its translocation. Tyrosine phosphorylation seems to occur only at the plasma membrane. Three isoforms exist from alternative splicing and Isoform 3 is catalytically inactive. (from LocusLink)
C30167	Protein_Inhibitor_of_Activated_STAT3_Protein	Signaling_Protein	Protein Inhibitor of Activated STAT3|PIAS3|Protein Inhibitor of Activated STAT Protein 3	Widely expressed by human PIAS3 Gene, 619-aa 67-kDa Protein Inhibitor of Activated STAT3 contains a SAP domain and a MIZ-type zinc finger and specifically inhibits the DNA-binding signaling activity of activated STAT3, a latent cytoplasmic transcription factor that becomes activated by tyrosine phosphorylation in response to cytokine stimulation. PIAS3 shares 83% identity with mouse Pias3, approximately 55% identity with PIAS1 and PIASX proteins, and 39% identity with PIASY. Independent of STAT3 binding and by direct binding, PIAS3 also appears to block MITF DNA-binding and transcription activity. (NCI)
C30168	Phosphoinositide-3-Kinase_Catalytic_Alpha_Polypeptide	Protein_Complex_Subunit	Phosphoinositide-3-Kinase Catalytic Alpha Polypeptide|EC 2.7.1.153|PI3-Kinase P110 Subunit Alpha|PI3K|PIK3CA|Phosphatidylinositol 3-Kinase, Catalytic, 110-kD, Alpha|Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit, Alpha Isoform|PtdIns-3-Kinase p110|p110-Alpha	Phosphoinositide-3-Kinase, Catalytic, Alpha Polypeptide, encoded by the PIK3CA gene, belongs to the PI3/PI4-kinase family. Phosphatidylinositol 3 Kinase is a heterodimer of a P110 (catalytic) and a P85 (regulatory) subunit. It phosphorylates PTDINS, PTDINS4P and PTDINS(4,5)P2 with a preference for PTDINS(4,5)P2. (from Swiss-Prot)
C30170	Phosphoinositide-3-Kinase_Catalytic_Beta_Polypeptide	Protein_Complex_Subunit	Phosphoinositide-3-Kinase Catalytic Beta Polypeptide|EC 2.7.1.153|PI3-Kinase p110 Subunit Beta|PI3K|PI3KBeta|PIK3CB|Phosphatidylinositol 3-Kinase, Catalytic, 110-kD, Beta|Phosphatidylinositol 3-Kinase, Catalytic, Beta|Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit, Beta Isoform|PtdIns-3-Kinase p110|p110-Beta	Phosphoinositide-3-Kinase, Catalytic, Beta Polypeptide, encoded by the PIK3CB gene, belongs to the PI3/PI4-kinase family. Phosphatidylinositol 3 Kinase is a heterodimer of a P110 (catalytic) and a P85 (regulatory) subunit. It phosphorylates PTDINS, PTDINS4P and PTDINS(4,5)P2 with a preference for PTDINS(4,5)P2. (from Swiss-Prot)
C30171	Phosphoinositide-3-Kinase_Catalytic_Gamma_Polypeptide	Protein_Complex_Subunit	Phosphoinositide-3-Kinase Catalytic Gamma Polypeptide|1-Phosphatidylinositol 3-Kinase|EC 2.7.1.153|PI3-Kinase|PI3-Kinase p110 Subunit Gamma|PI3K|PI3KGamma|PIK3CG|PTDINS-3-Kinase|Phosphatidylinositol 3 Kinase Gamma, p110 Gamma|Phosphatidylinositol 3-Kinase Catalytic 110-kD Gamma|Phosphatidylinositol 3-Kinase, Catalytic, Gamma Polypeptide|Phosphatidylinositol-4,5-Bisphosphate 3-Kinase Catalytic Subunit, Gamma Isoform|Phosphoinositide-3-Kinase Gamma Catalytic Subunit|PtdIns-3-Kinase p110|p110-Gamma	Phosphoinositide-3-Kinase, Catalytic, Gamma Polypeptide, encoded by the PIK3CG gene, belongs to the PI3/PI4-kinase family of proteins. This protein is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. (from LocusLink)
C30172	Phosphoinositide-3-Kinase_Regulatory_Subunit_Polypeptide-3	Protein_Complex_Subunit	Phosphoinositide-3-Kinase Regulatory Subunit Polypeptide 3|PIK3R3|Phosphatidylinositol 3-Kinase Regulatory Gamma Subunit|Phosphatidylinositol 3-Kinase, Regulatory Subunit, Polypeptide 3 (p55, Gamma)|Phosphatidylinositol 3-Kinase, Regulatory, 3|Phosphatidylinositol 3-Kinase, Regulatory, 55-kD, Gamma|Pi3-Kinase p85-Gamma Subunit|PtdIns-3-Kinase p85-Gamma|p55-Gamma|p55PIK	Phosphoinositide-3-Kinase, Regulatory Subunit, Polypeptide 3, encoded by the PIK3CG gene, binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. (from Swiss-Prot)
C30173	Phosphoinositide-4-Kinase_Catalytic_Beta_Polypeptide	Protein_Complex_Subunit	Phosphoinositide-4-Kinase Catalytic Beta Polypeptide|EC 2.7.1.67|NPIK|PI4K-Beta|PI4K92|PI4KBeta|PIK4CB|Phosphatidylinositol 4-Kinase Beta|Phosphatidylinositol 4-Kinase, Catalytic, Beta|Phosphatidylinositol 4-Kinase, Type III, Beta|Phosphatidylinositol 4-Kinase, Wortmannin-Sensitive|PtdIns 4-Kinase	Phosphoinositide-4-Kinase, Catalytic, Beta Polypeptide, encoded by the PIK4CB gene, belongs to the PI3/PI4-kinase family. This protein phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). It may regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation. Its enzymatic activity is inhibited by wortmannin. This protein is found in the outer membrane of mitochondria and membranes of the rough endoplasmic reticulum, and recruited to the Golgi complex by the small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2) on the Golgi complex. Two named isoforms exist resulting from alternative splicing. (from Swiss-Prot)
C30174	EVI2B_Protein	Transmembrane_Protein	EVI2B Protein|EVDB|Ecotropic Viral Integration Site 2B Protein	Expressed in bone marrow, peripheral mononuclear cells, and fibroblasts by human EVI2B Gene, 448-aa 49-kDa (precursor) EVI2B Protein is a Pro-rich type I membrane protein containing an N-terminal signal peptide, an extracellular domain with 4 potential glycosylation sites, a hydrophobic transmembrane domain, and a hydrophilic cytoplasmic domain. (NCI)
C30175	Enhancer_of_Zeste_Homolog_2_Protein	Regulatory_Protein	Enhancer of Zeste Homolog 2|ENX-1|EZH1|EZH2|Enhancer of Zeste 2	Expressed in many tissues by human EZH2 Gene (EZ Family/PcG Family), 746-aa 85-kDa nuclear Enhancer of Zeste Homolog 2 protein, containing a SET domain, may be involved in regulation of gene transcription and chromatin structure in the hematopoietic and central nervous systems. PcG proteins form multimeric protein complexes involved in transcriptional repression over successive cell generations. EZH2 appears to associate with embryonic ectoderm development protein VAV1 and with ATRX via the SET domain. (NCI)
C30176	Fatty_Acid_Binding_Protein-5	Ligand_Binding_Protein	Fatty Acid Binding Protein 5|EFABP|Epidermal Fatty Acid-Binding Protein|FABP5|PAFABP	Expressed in keratinocytes by human FABP5 Gene (FABP Family), highly conserved 135-aa 15-kDa cytoplasmic Fatty Acid Binding Protein 5 binds long-chain fatty acids with high specificity, and other hydrophobic ligands. Likely involved in fatty acid uptake, transport, or metabolism and in keratinocyte differentiation, FABP5 has highest affinity for C18 chain lengths and decreasing affinity for decreasing chain lengths or chains with double bonds. (NCI)
C32038	Abdominal_Aorta	Aortic_Segment	Abdominal Aorta
C32039	Abdominal_Aorta_Branch	Artery	Abdominal Aorta Branch
C32040	Abdominal_Muscle	Muscle	Abdominal Muscle
C32041	Accessory_Nerve	Cranial_Nerve	Accessory Nerve|Eleventh Cranial Nerve
C32042	Acetabulum	Joint_of_the_Pelvic_Girdle	Acetabulum
C32043	Achilles_Tendon	Tendon	Achilles Tendon|Calcanean Tendon
C32044	Acidophilic_Cell	Adenohypophysial_Cell	Acidophilic Cell	A cell whose cytoplasm or its granules stain with acid dyes.
C32045	Acinar_Salivary_Gland_System	Salivary_Gland_Tissue	Acinar Salivary Gland System	The glandular portion of the salivary system whose combined secretions constitute the saliva; a clear, alkaline, somewhat viscus secretion that keeps the mouth moist and aids in swallowing and digesting food. It includes the major salivary glands - sublingual, submandibular, and parotid glands, as well as numerous minor glands.
C32046	Acromial_Thoracic_Artery	Axillary_Artery_Branch	Acromial Thoracic Artery|Thoracoacromial Artery
C32047	Acromioclavicular_Joint	Joint_By_Site	Acromioclavicular Joint
C32048	Acromion	Musculoskeletal_System_Part	Acromion
C32049	Activated_Lymphocyte	Lymphocyte	Activated Lymphocyte	A white blood cell that, after being in contact with an antigen, rearranges its DNA to defend against that one specific type of antigen. After activation, it can then proliferate and differentiate into memory cells, antibody-secreting cells or plasma cells.
C32050	Adrenal_Gland_Capsule	Organ_Capsule	Adrenal Gland Capsule
C32051	Adrenal_Gland_Tissue	Tissue	Adrenal Gland Tissue
C32052	Alpha_Cell	Islet_Cell	Alpha Cell|Glucagon Cell|Glucagon Secreting Cell	A cell in the periphery of the pancreatic islets that secretes glucagon.
C32053	Alveolar_Cell	Epithelial_Cell	Alveolar Cell	A cell found in the walls of the pulmonary alveoli; the term is limited to alveolar epithelial cells (type I and type II alveolar cells).
C32054	Alveolar_Cell_Type_I	Alveolar_Cell	Alveolar Cell Type I|Type I Pneumocyte	A flattened cell of the alveolar epithelium, distinguished by their greatly attenuated cytoplasm and paucity of organelles.
C32055	Alveolar_Cell_Type_II	Alveolar_Cell	Alveolar Cell Type II|Type II Pneumocyte	A pleomorphic cell of the pulmonary alveolar epithelium that secretes surfactant and is distinguished by abundant cytoplasm containing numerous lipid-rich multilamellar bodies.
C32056	Alveolar_Duct	Duct|Lung_Tissue	Alveolar Duct	The respiratory passage distal to the respiratory bronchiole. Alveolar sacs and alveoli arise from the alveolar duct.
C32057	Alveolar_Sac	Lung_Tissue	Alveolar Sac	The terminal dilation of an alveolar duct that gives rise to alveoli in the lung.
C32058	Alveus	Brain_Part	Alveus
C32059	Ambient_Cistern	Lateral_Supratentorial_Cistern	Ambient Cistern
C32060	A-Microtubule	Cilium_Microtubule	A-Microtubule
C32061	Amphiarthrosis	Joint	Amphiarthrosis
C32063	Ampullary_Crest	Ear_Part	Ampullary Crest|Cristae Ampullaris
C32064	Ampullary_Segment_of_the_Fallopian_Tube	Female_Reproductive_System_Part	Ampullary Segment of the Fallopian Tube
C32065	Amygdaloid_Body	Brain_Part	Amygdaloid Body|Amygdaloid Nucleus
C32067	Anal_Column	Gastrointestinal_System_Part	Anal Column
C32068	Anal_Gland	Exocrine_Gland	Anal Gland
C32069	Anal_Region	Body_Region	Anal Region
C32070	Anal_Sinus	Sinus	Anal Sinus
C32071	Anal_Squamous_Zone	Gastrointestinal_System_Part	Anal Squamous Zone
C32072	Anal_Transitional_Zone	Gastrointestinal_System_Part	Anal Transitional Zone
C32073	Anastomosing_Tubule_of_the_Smooth_Endoplasmic_Reticulum	Cell_Part	Anastomosing Tubule of the Smooth Endoplasmic Reticulum
C32074	Anastomotica_Magna_Artery	Brachial_Artery_Branch	Anastomotica Magna Artery
C32076	Angular_Artery	Middle_Cerebral_Artery_Branch	Angular Artery
C32077	Angular_Gyrus	Cerebral_Gyrus	Angular Gyrus
C32078	Ankle_Joint	Joint_By_Site	Ankle Joint
C32079	Anterior_Annular_Ligament	Ligament	Anterior Annular Ligament
C32080	Anterior_Carpal_Artery	Ulnar_Artery_Branch	Anterior Carpal Artery
C32081	Anterior_Caudate_Vein	Vein	Anterior Caudate Vein
C32082	Anterior_Cerebral_Artery_Branch	Internal_Carotid_Artery_Branch	Anterior Cerebral Artery Branch
C32083	Anterior_Choroidal_Artery	Internal_Carotid_Artery_Branch	Anterior Choroidal Artery
C32084	Anterior_Circulation_Intracranial_Artery	Intracranial_Artery	Anterior Circulation Intracranial Artery
C32085	Anterior_Circumflex_Artery	Axillary_Artery_Branch	Anterior Circumflex Artery
C32086	Anterior_Commissure	Brain_Part	Anterior Commissure
C32087	Anterior_Communicating_Artery	Internal_Carotid_Artery_Branch	Anterior Communicating Artery
C32088	Anterior_Cruciate_Ligament	Ligament	Anterior Cruciate Ligament
C32089	Anterior_Descending_Coronary_Artery	Left_Coronary_Artery_Branch	Anterior Descending Coronary Artery
C32090	Anterior_Fossa	Fossa	Anterior Fossa
C32091	Anterior_Inferior_Cerebellar_Artery	Basilar_Artery_Branch	Anterior Inferior Cerebellar Artery|AICA
C32092	Anterior_Inferior_Frontal_Convolution	Inferior_Frontal_Convolution	Anterior Inferior Frontal Convolution|Pars Orbitalis
C32093	Anterior_Infratentorial_Cistern	Infratentorial_Cistern	Anterior Infratentorial Cistern
C32094	Anterior_Jugular_Vein	Jugular_Vein	Anterior Jugular Vein
C32095	Anterior_Longitudinal_Ligament	Ligament	Anterior Longitudinal Ligament
C32096	Anterior_Median_Fissure_of_Spinal_Cord	Spinal_Cord_Fissure	Anterior Median Fissure of the Spinal Cord|Anterior Median Fissure of Spinal Cord
C32097	Anterior_Mediastinal_Lymph_Node	Mediastinal_Lymph_Node	Anterior Mediastinal Lymph Node
C32098	Anterior_Mediastinum	Mediastinum_Part	Anterior Mediastinum
C32099	Anterior_Meningeal_Artery	Vertebral_Artery_Branch	Anterior Meningeal Artery
C32100	Anterior_Olfactory_Lobule	Brain_Part	Anterior Olfactory Lobule
C32101	Anterior_Parietal_Artery	Middle_Cerebral_Artery_Branch	Anterior Parietal Artery
C32102	Anterior_Part_of_the_Calcarine_Fissure	Cerebral_Fissure	Anterior Part of the Calcarine Fissure
C32103	Anterior_Pole_of_the_Lens	Eye_Part	Anterior Pole of the Lens
C32104	Anterior_Portion_of_the_Corpus_Callosum_Cistern	Brain_Part	Anterior Portion of the Corpus Callosum Cistern
C32105	Anterior_Quadrigeminal_Body	Quadrigeminal_Body	Anterior Quadrigeminal Body|Superior Colliculus
C32106	Anterior_Supratentorial_Cistern	Supratentorial_Cistern	Anterior Supratentorial Cistern|Parasellar Cistern
C32107	Anterior_Surface_of_the_Kidney	Anatomic_Surface|Kidney_Part	Anterior Surface of the Kidney
C32108	Anterior_Surface_of_the_Lens	Anatomic_Surface	Anterior Surface of the Lens
C32109	Anterior_Surface_of_the_Liver	Anatomic_Surface|Gastrointestinal_System_Part	Anterior Surface of the Liver
C32111	Anterior_Surface_of_the_Stomach	Anatomic_Surface|Gastrointestinal_System_Part	Anterior Surface of the Stomach
C32112	Anterior_Surface_of_the_Vagina	Anatomic_Surface|Female_Reproductive_System_Part	Anterior Surface of the Vagina
C32113	Anterior_Temporal_Artery	Middle_Cerebral_Artery_Branch	Anterior Temporal Artery
C32114	Anterior_Tibial_Artery_Branch	Artery	Anterior Tibial Artery Branch
C32115	Anterior_Tibial_Vein	Tibial_Vein	Anterior Tibial Vein
C32116	Anterior_Ulnar_Vein	Superficial_Vein	Anterior Ulnar Vein
C32117	Anterior_Wall_of_the_Tympanum	Ear_Part	Anterior Wall of the Tympanum
C32118	Antero-lateral_Ascending_Tract	Spinal_Cord_Part	Antero-Lateral Ascending Tract
C32119	Antero-lateral_Column	Spinal_Cord_Column	Antero-Lateral Column
C32120	Antihelix	Ear_Part	Antihelix
C32121	Antitragus	Ear_Part	Antitragus
C32123	Aortic_Arch	Embryonic_Artery	Aortic Arch
C32124	Aortic_Arch_Branch	Artery	Aortic Arch Branch
C32125	Aortic_Opening	Diaphragm_Part	Aortic Opening
C32126	Apex_of_the_Heart	Heart_Part	Apex of the Heart
C32127	Apex_of_the_Lung	Respiratory_System_Part	Apex of the Lung
C32128	Apex_of_the_Pericardium	Membrane_Part	Apex of the Pericardium
C32130	Apex_of_the_Tongue	Organ_of_Special_Sense_Part	Apex of the Tongue|Apex of Tongue|Tip of Tongue|Tip of the Tongue
C32131	Apical_Domain_of_the_Epithelium	Epithelium_Part	Apical Domain of the Epithelium|Apical Domain of Epithelium|Free Surface of Epithelium|Free Surface of the Epithelium
C32132	Apocrine_Sweat_Gland	Sweat_Gland	Apocrine Sweat Gland
C32133	Aponeurosis	Musculoskeletal_System_Part	Aponeurosis
C32135	Aqueduct_of_Sylvius	Brain_Part	Aqueduct of Sylvius
C32136	Arachnoid_Membrane	Membrane_of_the_Brain_or_Spinal_Cord	Arachnoid Membrane	A delicate fibrous membrane interposed between the dura mater and the pia mater of the brain and spinal cord. It is separated from the pia mater by the subarachnoid space.
C32137	Arachnoid_Villus	Central_Nervous_System_Part	Arachnoid Villus|Glandulae Pacchioni
C32138	Arch_of_the_Vertebra	Musculoskeletal_System_Part	Arch of the Vertebra
C32139	Area_of_Broca	Brain_Part	Area of Broca
C32140	Argentaffin_Cell	Enteroendocrine_Cell	Argentaffin Cell	An enteroendocrine cell located in the basilar portions of the glands of the gastrointestinal tract. The granules in the cell stain readily with chromium and silver salts without pretreatment with a reducing agent.
C32141	Arm	Upper_Extremity_Part	Arm	Technically the part of the superior limb between the shoulder and the elbow but commonly used to refer to the whole superior limb.
C32142	Arteriovenous_Shunt	Blood_Vessel	Arteriovenous Shunt|AV Anastomosis|AV Shunt|Arteriovenous Anastomosis
C32143	Articular_Bone_Surface	Bone_Surface	Articular Bone Surface
C32144	Articular_Cartilage	Cartilage	Articular Cartilage
C32145	Articular_Muscle	Muscle	Articular Muscle
C32146	Aryepiglottic_Muscle	Laryngeal_Muscle	Aryepiglottic Muscle
C32147	Aryteno-epiglottic_Fold	Head_and_Neck_Part	Aryteno-Epiglottic Fold
C32148	Arytenoid_Cartilage	Laryngeal_Cartilage	Arytenoid Cartilage
C32149	Arytenoid_Muscle	Laryngeal_Muscle	Arytenoid Muscle
C32150	Ascending_Aorta	Aortic_Segment	Ascending Aorta
C32151	Ascending_Aorta_Branch	Artery	Ascending Aorta Branch
C32152	Ascending_Frontal_Artery	Middle_Cerebral_Artery_Branch	Ascending Frontal Artery
C32153	Ascending_Frontal_Convolution	Brain_Part	Ascending Frontal Convolution
C32154	Ascending_Limb_of_the_Henle_s_Loop	Kidney_Part	Ascending Limb of Henle's Loop
C32155	Ascending_Parietal_Convolution	Brain_Part	Ascending Parietal Convolution
C32156	Astragalus	Tarsal_Bone	Astragalus
C32157	Atlanto-axial_Joint	Joint_By_Site	Atlanto-Axial Joint
C32158	Atlanto-occipital_Joint	Joint_By_Site	Atlanto-Occipital Joint
C32159	Atlas_of_the_Vertebra	Musculoskeletal_System_Part	Atlas of the Vertebra
C32160	Atrioventricular_Bundle	Heart_Part	Atrioventricular Bundle|A-V Bundle|Bundle of His
C32161	Atrioventricular_Node	Heart_Part	Atrioventricular Node|A-V Node
C32162	Atrium_of_the_Middle_Ear	Ear_Part	Atrium of the Middle Ear
C32163	Attachment_Plaque	Cell_Part	Attachment Plaque
C32164	Auditory_Ossicle	Ear_Part	Auditory Ossicle|Bone of Tympanum|Bone of the Tympanum
C32165	Auricle	Ear_Part	Auricle
C32166	Autophagolysosome	Lysosome	Autophagolysosome
C32167	Autophagosome	Lysosome	Autophagosome
C32168	Autosome	Chromosome	Autosome	A chromosome not involved in sex determination. The diploid human genome consists of a total of 46 chromosomes which includes 22 pairs of autosomes.
C32169	Axillary_Artery	Artery	Axillary Artery
C32170	Axillary_Artery_Branch	Artery	Axillary Artery Branch
C32171	Axillary_Vein	Deep_Vein	Axillary Vein
C32172	Axial_Skeleton	Other_Anatomic_Concept	Axial Skeleton|Appendicular Skeleton	The part of the skeleton that includes the skull and spinal column and sternum and ribs.
C32173	Axis_of_the_Centriole	Cell_Part	Axis of the Centriole
C32174	Axis_of_the_Vertebra	Musculoskeletal_System_Part	Axis of the Vertebra
C32175	Axoaxonic_Synapse	Synapse	Axoaxonic Synapse
C32176	Axodendritic_Synapse	Synapse	Axodendritic Synapse
C32177	Axon	Nervous_System_Part	Axon|Nerve Fiber
C32178	Axosomatic_Synapse	Synapse	Axosomatic Synapse
C32179	Azurophilic_Granule	Cell_Part	Azurophilic Granule
C32180	Azygos_Articular_Artery	Popliteal_Artery_Branch	Azygos Articular Artery
C32181	Balbiani_Body	Cell_Part	Balbiani Body
C32182	Barr_Body	Cell_Part	Barr Body
C32183	Basal_Body	Nonmembranous_Cytoplasmic_Organelle	Basal Body
C32184	Basal_Cerebral_Vein_of_the_Rosenthal	Vein	Basal Cerebral Vein of Rosenthal
C32185	Basal_Domain_of_the_Epithelium	Epithelium_Part	Basal Domain of the Epithelium
C32186	Basal_Lamina	Epithelium_Part	Basal Lamina|Lamina Densa
C32187	Basal_Lamina_Collagen	Epithelium_Part	Basal Lamina Collagen
C32188	Basal_Lamina_of_the_Vascular_Endothelium	Tissue_Part	Basal Lamina of the Vascular Endothelium
C32189	Basal_Layer_of_the_Endometrium	Female_Reproductive_System_Part	Basal Layer of the Endometrium
C32190	Basaloid_Cell	Epithelial_Cell	Basaloid Cell	A cell usually of the epidermis that resembles a basal cell.
C32191	Base_of_the_Brain	Brain_Part	Base of the Brain|Base of Brain
C32192	Base_of_the_Lung	Respiratory_System_Part	Base of the Lung
C32193	Base_of_the_Pericardium	Membrane_Part	Base of the Pericardium
C32195	Basilar_Artery_Branch	Posterior_Circulation_Intracranial_Artery	Basilar Artery Branch
C32196	Basilar_Membrane_of_the_Membranous_Canal_of_the_Cochlea	Basilar_Membrane	Basilar Membrane of the Membranous Canal of the Cochlea	The wall of the cochlear duct, which separates it from the scala tympani. It vibrates in response to sound, exciting the hair cells and supports the organ of Corti.
C32197	Basilic_Vein	Superficial_Vein	Basilic Vein
C32198	Basophilic_Cell	Adenohypophysial_Cell	Basophilic Cell	A cell whose cytoplasm or granules stain readily with basic dyes.
C32199	Beta_Cell	Islet_Cell	Beta Cell|Insulin Cell|Insulin Secreting Cell	A cell that composes the bulk of the islets of Langerhans and secretes insulin.
C32200	Biceps	Muscle	Biceps|Biceps Brachii Muscle
C32201	Bicuspid_Tooth	Permanent_Tooth	Bicuspid Tooth|Premolar Tooth
C32202	Bile_Canaliculus	Gastrointestinal_System_Part	Bile Canaliculus
C32203	Bile_Salt	Body_Fluid_or_Substance	Bile Salt
C32204	Birbeck_Granule	Cell_Part	Birbeck Granule
C32205	Bladder_Mucosa	Bladder_Tissue|Mucosa	Bladder Mucosa
C32206	Bladder_Muscular_Coat	Bladder_Tissue	Bladder Muscular Coat
C32207	Bladder_Muscularis_Mucosa	Bladder_Mucosa|Muscularis_Mucosa	Bladder Muscularis Mucosa
C32208	Bladder_Serosal_Surface	Anatomic_Surface|Bladder_Tissue|Serosa	Bladder Serosal Surface
C32209	Bladder_Tissue	Tissue	Bladder Tissue
C32210	Bladder_Transitional_Cell	Urothelial_Cell	Bladder Urothelial Cell|Bladder Transitional Cell	An epithelial cell, found in the bladder, originally thought to represent a transitional form between stratified squamous and columnar epithelial cells.  In the contracted condition the epithelium consists of many cell layers, whereas in the stretched condition usually only two layers of cells can be distinguished.
C32211	Bladder_Transitional_Cell_Epithelium	Urothelium	Bladder Urothelium|Bladder Transitional Cell Epithelium
C32212	Blood_Capillary	Blood_Vessel|Capillary	Blood Capillary
C32213	Blood_Vessel_Tissue	Soft_Tissue	Blood Vessel Tissue
C32214	B-Microtubule	Cilium_Microtubule	B-Microtubule
C32215	Body_Cavity	Retired_Concepts	Body Cavity
C32216	Body_of_the_Corpus_Callosum	Brain_Part	Body of the Corpus Callosum
C32217	Body_of_the_Epididymis	Male_Reproductive_System_Part	Body of the Epididymis
C32218	Body_of_the_Lateral_Ventricle	Brain_Part	Body of the Lateral Ventricle
C32219	Body_of_the_Nail	Integumentary_System_Part	Body of the Nail
C32220	Body_of_the_Spermatozoon	Male_Reproductive_System_Part	Body of the Spermatozoon
C32221	Body_Part	Anatomic_Structure_System_or_Substance	Body Part	Any part of an organism.
C32222	Bone_Matrix	Bone_Tissue	Bone Matrix
C32223	Bone_of_the_Extremity	Bone	Bone of the Extremity|Bone of Extremity
C32224	Bone_Surface	Anatomic_Surface	Bone Surface
C32225	Bowman_s_Capsule	Kidney_Part|Organ_Capsule	Bowman's Capsule|Malpighian Capsule
C32226	Bowman_s_Membrane	Membrane	Bowman's Membrane	A transparent homogeneous acellular layer, 6 to 9 um thick, lying between the basal lamina of the outer layer of stratified epithelium and the substantia propria of the cornea; it is considered to be a basement membrane.
C32227	Brachial_Artery_Branch	Artery	Brachial Artery Branch
C32228	Brain_Infundibulum	Brain_Part	Brain Infundibulum
C32230	Bronchial_Artery	Thoracic_Aorta_Branch	Bronchial Artery
C32231	Bronchial_Epithelium	Pseudostratified_Columnar_Ciliated_Epithelium	Bronchial Epithelium
C32232	Bronchial_Lymph_Node	Lymph_Node_by_Anatomic_Site	Bronchial Lymph Node
C32233	Bronchial_Tree	Organ	Bronchial Tree
C32234	Bronchus-Associated_Lymphoid_Tissue	Mucosa-Associated_Lymphoid_Tissue	Bronchus-Associated Lymphoid Tissue|BALT
C32235	Brown_Adipose_Tissue	Adipose_Tissue	Brown Adipose Tissue
C32236	Brush_Cell	Glandular_Cell	Brush Cell	A cell characterized by the presence of a tuft of blunt, squat microvilli (120-140/cell) on the cell surface. The microvilli contain filaments that stretch into the underlying cytoplasm. It has a distinctive pear shape with a wide base and a narrow microvillus apex. This cell is distinct from the unipolar brush cell found in the cerebellar cortex.
C32237	Buccal_Salivary_Gland	Minor_Salivary_Gland	Buccal Salivary Gland
C32239	C1_Vertebra	Cervical_Vertebra	C1 Vertebra
C32240	C2_Vertebra	Cervical_Vertebra	C2 Vertebra
C32241	C3_Vertebra	Cervical_Vertebra	C3 Vertebra
C32242	C4_Vertebra	Cervical_Vertebra	C4 Vertebra
C32243	C5_Vertebra	Cervical_Vertebra	C5 Vertebra
C32244	C6_Vertebra	Cervical_Vertebra	C6 Vertebra
C32245	C7_Vertebra	Cervical_Vertebra	C7 Vertebra
C32246	CA1_Field_of_the_Cornu_Ammonis	Brain_Part	CA1 Field of the Cornu Ammonis
C32247	CA2_Field_of_the_Cornu_Ammonis	Brain_Part	CA2 Field of the Cornu Ammonis
C32248	CA3_Field_of_the_Cornu_Ammonis	Brain_Part	CA3 Field of the Cornu Ammonis
C32249	CA4_Field_of_the_Cornu_Ammonis	Brain_Part	CA4 Field of the Cornu Ammonis
C32250	Calcaneum	Tarsal_Bone	Calcaneum
C32251	Calcarine_Artery	Posterior_Cerebral_Artery_Branch	Calcarine Artery
C32252	Calcarine_Sulcus	Cerebral_Sulcus	Calcarine Sulcus
C32253	Callosomarginal_Artery	Anterior_Cerebral_Artery_Branch	Callosomarginal Artery
C32254	Canal_for_Tensor_Tympani	Ear_Part	Canal for Tensor Tympani
C32255	Canal_of_Hering	Gastrointestinal_System_Part	Canal of Hering
C32256	Canal_of_Schlemm	Eye_Part	Canal of Schlemm
C32257	Canalis_Radicis_Dentis	Tooth_Tissue	Canalis Radicis Dentis	The portion of the dental pulp cavity in the root of a tooth, extending from the pulp chamber to the apical foramen. More than one canal may be present in a single root.
C32258	Canine_Tooth	Permanent_Tooth	Canine Tooth
C32259	Capsular_Ligament	Laryngeal_Ligament	Capsular Ligament
C32261	Cardia_Gland	Exocrine_Gland	Cardia Gland
C32262	Cardia_Orifice	Gastrointestinal_System_Part	Cardia Orifice
C32263	Carotid_Cistern	Anterior_Supratentorial_Cistern	Carotid Cistern
C32264	Carpal_Joint	Joint_By_Site	Carpal Joint
C32265	Carpometacarpal_Joint	Joint_By_Site	Carpometacarpal Joint
C32266	Carpus_Bone	Short_Bone	Carpus Bone
C32267	Cartilage_Matrix	Musculoskeletal_System_Part	Cartilage Matrix
C32268	Cartilagenous_Tissue	Connective_Tissue	Cartilagenous Tissue
C32269	Cavum_Conchae	Ear_Part	Cavum Conchae
C32270	Perikaryon	Nervous_System_Part	Perikaryon|Cell Body
C32271	Cell_of_the_Epidermis	Cell	Cell of the Epidermis	An epithelial cell of the outer most layer of the skin.
C32272	Cell-to-extracellular_Matrix_Junction	Epithelial_Cell_Junction	Cell-to-Extracellular Matrix Junction
C32273	Cellular_Pump	Retired_Concepts	Cellular Pump
C32274	Cementoblast	Tooth_Cell	Cementoblast	A large cell ranging in shape from cuboidal to squamous with a large central nucleus. The nucleus usually has a single nucleolus, which is active in the formation of cementum.
C32275	Cementocyte	Tooth_Cell	Cementocyte	A cell in a hollow cavity of cellular cementum, ranging in shape from round to oval or flattened, and exhibiting numerous protoplasmic processes extending from its free surface.
C32276	Cementum	Tooth_Tissue	Cementum	Bone-like rigid connective tissue covering the root of a tooth from the cementoenamel junction to the apex and lining the apex of the root canal. It serves as an attachment for the periodontal ligament, thus assisting in tooth support.
C32277	Central_Artery	Middle_Cerebral_Artery_Branch	Central Artery
C32278	Central_Lobe	Brain_Part	Central Lobe|Island of Reil
C32279	Central_Pore_of_the_Nuclear_Pore_Complex	Cell_Part	Central Pore of the Nuclear Pore Complex|Central Pore of NPC|Central Pore of Nuclear Pore Complex|Central Pore of the NPC
C32280	Central_Sulcus_of_Rolando	Cerebral_Sulcus	Central Sulcus of Rolando
C32281	Central_Vein	Deep_Vein	Central Vein
C32282	Central_Zone_of_the_Prostatic_Parenchyma	Prostatic_Tissue	Central Zone of the Prostatic Parenchyma	Part of the functional area of the prostate that is above and in front of the transitional zone. The central zone comprises about 20-25% of the gland and is the location of about 10% of the prostate cancers found in the gland.
C32283	Centriole	Nonmembranous_Cytoplasmic_Organelle	Centriole
C32284	Centromedian_Nucleus_of_the_Thalamus	Brain_Part	Centromedian Nucleus of the Thalamus
C32285	Centrosome	Cell_Part	Centrosome|MTOC|Microtubule-organizing Center
C32286	Cephalic_Vein	Superficial_Vein	Cephalic Vein
C32287	Cerebral_Aqueduct	Brain_Part	Cerebral Aqueduct
C32288	Cerebral_Fissure	Brain_Part	Cerebral Fissure
C32289	Cerebral_Fornix	Brain_Part	Cerebral Fornix
C32290	Cerebral_Gyrus	Brain_Part	Cerebral Gyrus
C32291	Cerebral_Peduncle	Brain_Part	Cerebral Peduncle
C32292	Cerebral_Sulcus	Brain_Part	Cerebral Sulcus
C32293	Cerumen	Exocrine_Gland_Fluid_or_Secretion	Cerumen|Earwax
C32294	Ceruminous_Gland	Apocrine_Sweat_Gland	Ceruminous Gland
C32295	Cervical_Curve	Musculoskeletal_System_Part	Cervical Curve
C32296	Cervical_Gland	Exocrine_Gland	Cervical Gland
C32297	Cervical_Gland_Secretion	Female_Genital_System_Fluid_or_Secretion	Cervical Gland Secretion
C32298	Cervical_Lymph_Node	Lymph_Node_by_Anatomic_Site	Cervical Lymph Node
C32299	Cervical_Nerve	Spinal_Nerve	Cervical Nerve
C32301	Chamber_of_the_Eye	Eye_Part	Chamber of the Eye
C32302	Chemical_Synapse	Synapse	Chemical Synapse	A synapse in which an action potential causes the exocytosis of neurotransmitter from the presynaptic cell, which diffuses across the synaptic cleft and binds to ligand gated ion channels on the post synaptic cell. These ion channels then affect the resting potential of the post synaptic cell. (On-line Medical Dictionary)
C32303	Chemical_Synapse_Component	Cell_Part	Chemical Synapse Component
C32304	Chiasmatic_Cistern	Anterior_Supratentorial_Cistern	Chiasmatic Cistern
C32305	Chief_Cell_of_the_Stomach	Chief_Cell|Gastric_Glandular_Cell	Chief Cell of the Stomach|Chief Cell (Stomach)|Chief Cells, Gastric	An epithelial cell of the stomach that secretes digestive enzymes. Chief cells may be found at any level in the fundic glands, but are most common in the deeper region, toward the muscularis mucosae. They are basophilic.
C32306	Chondroblast	Cartilage_Cell	Chondroblast	A cartilage-forming cell derived from a mesenchymal cell. The chondroblast secretes hyaluronidase, chondroitin sulfates, and collagen II to form a collagen matrix. It differentiates into a chondrocyte.
C32307	Chordae_Tendineae	Heart_Part	Chordae Tendineae
C32308	Choroid_Plexus_of_the_Fourth_Ventricle	Choroid_Plexus	Choroid Plexus of the Fourth Ventricle
C32309	Choroid_Plexus_of_the_Lateral_Ventricle	Choroid_Plexus	Choroid Plexus of the Lateral Ventricle
C32310	Choroidal_Artery	Vertebral_Artery_Branch	Choroidal Artery
C32311	Choroidal_Fissure	Cerebral_Fissure	Choroidal Fissure
C32312	Chromatin_Fibril	Cell_Part	Chromatin Fibril
C32313	Chromophobe_Cell	Adenohypophysial_Cell	Chromophobe Cell	A small, faintly staining cell with scanty cytoplasm and rounded or polygonal contours. It is found in clusters in the anterior lobe of the pituitary gland.
C32314	Ciliary_Epithelium	Columnar_Epithelium	Ciliary Epithelium
C32315	Ciliary_Muscle	Eye_Part|Muscle	Ciliary Muscle
C32316	Ciliary_Process	Eye_Part	Ciliary Process
C32317	Ciliated_Bronchial_Epithelial_Cell	Columnar_Cell	Ciliated Bronchial Epithelial Cell	A columnar-shaped cell found in the epithelium of the lobular bronchiole. Each cell contains 200-300 cilia 5-8 mm long. The cilia are part of the mucociliary system, which extends through the tracheobronchial tree and into the respiratory bronchioles. This system protects the respiratory surface from dirt and airborne infection and represents the principal mechanism of defense in the respiratory tract. The cilia beat in unison (about 1,000 strokes per minute) and in a wave-like fashion, thereby propelling mucus and entrapped foreign material toward the oropharynx for expectoration or swallowing.
C32318	Cilium	Epithelium_Part	Cilium
C32319	Cilium_Microtubule	Microtubule	Cilium Microtubule
C32320	Circular_Ligament_of_the_Tooth	Ligament	Circular Ligament of the Tooth
C32321	Circular_Sulcus	Cerebral_Sulcus	Circular Sulcus
C32322	Circumvallate_Papilla	Papilla_of_the_Tongue	Circumvallate Papilla
C32323	Cis-Golgi_Network	Cell_Part	Cis-Golgi Network|CGN
C32324	Cisterna_Magna	Posterior_Infratentorial_Cistern	Cisterna Magna|Cerebellomedullary Cistern
C32325	Cisterna_of_the_Endosome	Cell_Part	Cisterna of the Endosome
C32326	Cisterna_of_the_Golgi_Apparatus	Cell_Part	Cisterna of the Golgi Apparatus
C32327	Cisterna_of_the_Rough_Endoplasmic_Reticulum	Cell_Part	Cisterna of the Rough Endoplasmic Reticulum
C32328	Classic_Lobule	Hepatic_Lobule	Classic Lobule
C32329	Claustrum	Brain_Part	Claustrum
C32330	C-Microtubule	Cell_Part	C-Microtubule
C32331	Coated_Vesicle	Transport_Vesicle	Coated Vesicle
C32332	Coccygeal_Muscle	Pelvic_Floor_Muscle	Coccygeal Muscle
C32333	Coccygeal_Nerve	Spinal_Nerve	Coccygeal Nerve
C32334	Coccygeal_Vertebra	Vertebra	Coccygeal Vertebra
C32335	Cochlear_Duct	Duct	Cochlear Duct
C32336	Cochlear_Labyrinth	Ear_Part	Cochlear Labyrinth
C32337	Cochlear_Nucleus	Central_Nervous_System_Part	Cochlear Nucleus
C32338	Collagen_Fiber	Connective_Tissue_Fiber	Collagen Fiber
C32339	Collagen_Fibril	Skin_Part	Collagen Fibril
C32340	Collateral_Fissure	Cerebral_Fissure	Collateral Fissure
C32341	Collateral_Gyrus	Cerebral_Gyrus	Collateral Gyrus
C32342	Collateral_Sulcus	Temporal_Sulcus	Collateral Sulcus
C32343	Collecting_Cell	Cuboidal_Cell	Collecting Cell	A simple cuboidal epithelial cell lining the collecting duct of the kidney. Its function is dependent upon its location on the collecting duct.
C32344	Collecting_Tube	Kidney_Part	Collecting Tube|Straight Tube
C32345	Colloid	Substance	Colloid	A mixture of microscopic particles suspended in some sort of liquid medium.
C32346	Collum_Dentis	Head_and_Neck_Part	Collum Dentis|Neck of Tooth|Neck of the Tooth
C32347	Colorectal_Zone_of_the_Anal_Canal	Gastrointestinal_System_Part	Colorectal Zone of the Anal Canal
C32348	Colostrum	Body_Fluid_or_Substance	Colostrum
C32349	Commissure	Spinal_Cord_Part	Commissure
C32350	Common_Bony_Limb	Ear_Part	Common Bony Limb
C32351	Common_Canaliculus	Head_and_Neck_Part	Common Canaliculus
C32352	Common_Carotid_Artery	Carotid_Artery	Common Carotid Artery
C32353	Common_Carotid_Artery_Branch	Artery	Common Carotid Artery Branch
C32354	Common_Femoral_Artery	Femoral_Artery_Branch	Common Femoral Artery
C32355	Common_Femoral_Artery_Branch	Artery	Common Femoral Artery Branch
C32356	Common_Hepatic_Duct	Extrahepatic_Bile_Duct|Hepatic_Duct	Common Hepatic Duct
C32357	Common_Iliac_Artery	Abdominal_Aorta_Branch	Common Iliac Artery
C32358	Common_Iliac_Artery_Branch	Artery	Common Iliac Artery Branch
C32359	Common_Iliac_Vein	Iliac_Vein	Common Iliac Vein
C32360	Common_Thymocyte	Thymocyte	Common Thymocyte	A lymphocyte found in the thymus. It is a precursor to a mature T-lymphocyte.
C32361	Common_Ulnar_Vein	Superficial_Vein	Common Ulnar Vein
C32362	Concha	Ear_Part	Concha
C32363	Condensed_Configuration_of_the_Mitochondrion	Mitochondrion	Condensed Configuration of the Mitochondrion
C32365	Conjunctival_Epithelium	Stratified_Columnar_Epithelium	Conjunctival Epithelium
C32366	Connecting_Segment_of_the_Photoreceptor_Cell	Eye_Part	Connecting Segment of the Photoreceptor Cell
C32367	Connective_Tissue_Component_of_the_Peripheral_Nerve	Connective_Tissue	Connective Tissue Component of the Peripheral Nerve
C32368	Connective_Tissue_Fiber	Tissue_Part	Connective Tissue Fiber
C32369	Connective_Tissue_Proper	Connective_Tissue	Connective Tissue Proper
C32370	Continuous_Capillary	Capillary	Continuous Capillary
C32371	Corneoscleral_Coat	Eye_Part	Corneoscleral Coat
C32373	Corniculate_Cartilage	Laryngeal_Cartilage	Corniculate Cartilage
C32374	Cornu_Ammonis	Brain_Part	Cornu Ammonis|CA
C32375	Corona_Dentis	Head_and_Neck_Part	Corona Dentis|Crown of Tooth|Crown of the Tooth
C32376	Coronary_Artery_Branch	Retired_Concepts	Coronary Artery Branch
C32377	Coronary_Ligament	Liver_Ligament	Coronary Ligament
C32378	Coronary_Sinus	Heart_Part	Coronary Sinus
C32379	Coronary_Valve	Cardiac_Valve	Coronary Valve
C32380	Corpora_Albicantia	Brain_Part	Corpora Albicantia
C32382	Corpora_Cavernosa	Male_Reproductive_System_Part	Corpora Cavernosa
C32383	Corpus_Callosum_Cistern	Superior_Supratentorial_Cistern	Corpus Callosum Cistern
C32384	Corpus_Spongiosum	Male_Reproductive_System_Part	Corpus Spongiosum
C32385	Cortical_Arch	Kidney_Part	Cortical Arch
C32386	Cortical_Cell_Layer	Nervous_Tissue	Cortical Cell Layer	Cerebral tissue composed of cells with distinctive characteristics. The cerebral cortex contains six cell layers.
C32387	Cortical_Column	Kidney_Part	Cortical Column|Column of Bertini|Renal Column of Bertini
C32388	Cortical_Nephron	Kidney_Part	Cortical Nephron|Subcapsular Nephron
C32389	Cortical_Vein	Vein	Cortical Vein
C32390	Corticotrope_Cell	Glandular_Cell	Corticotrope Cell|ACTH Cell
C32391	Costal_Cartilage	Cartilage	Costal Cartilage
C32392	Costochondral_Joint	Joint_By_Site	Costochondral Joint
C32393	Costophrenic_Angle	Diaphragm_Part	Costophrenic Angle
C32394	Costovertebral_Joint	Joint_By_Site	Costovertebral Joint
C32395	Cowper_s_Gland	Exocrine_Gland	Cowper's Gland|Bulbourethral Gland
C32396	Cremaster_Muscle	Superficial_Abdominal_Muscle	Cremaster Muscle
C32397	Cricoarytenoid_Joint	Joint_By_Site	Cricoarytenoid Joint
C32398	Cricoarytenoid_Muscle	Laryngeal_Muscle	Cricoarytenoid Muscle
C32399	Cricoesophageal_Tendon	Tendon	Cricoesophageal Tendon
C32400	Cricoid_Cartilage	Laryngeal_Cartilage	Cricoid Cartilage
C32401	Cricopharyngeus_Muscle	Pharyngeal_Muscle	Cricopharyngeus Muscle|Inferior Constrictor Muscle of Pharynx|Inferior Constrictor Muscle of the Pharynx
C32402	Cricothyroid_Joint	Joint_By_Site	Cricothyroid Joint
C32403	Cricothyroid_Ligament	Laryngeal_Ligament	Cricothyroid Ligament
C32404	Cricothyroid_Muscle	Laryngeal_Muscle	Cricothyroid Muscle
C32405	Cricotracheal_Ligament	Laryngeal_Ligament	Cricotracheal Ligament
C32406	Crossed_Pyramidal_Tract	Spinal_Cord_Part	Crossed Pyramidal Tract
C32407	Crosslinker	Cell_Part	Crosslinker
C32408	Crural_Cistern	Lateral_Supratentorial_Cistern	Crural Cistern
C32409	Crus_Cerebri	Brain_Part	Crus Cerebri
C32410	Crus_Helicis	Ear_Part	Crus Helicis
C32411	Crypts_of_the_Lieberkuhn	Gastrointestinal_System_Part	Crypt of Lieberkuhn
C32412	Crystal_of_Reinke	Male_Reproductive_System_Part	Crystal of Reinke
C32413	Crystalline_Inclusion	Cytoplasmic_Inclusion	Crystalline Inclusion
C32414	Cuboid_Bone	Tarsal_Bone	Cuboid Bone
C32415	Cuboidal_Epithelium	Glandular_Epithelium	Cuboidal Epithelium
C32416	Cuneiform_Bone_of_the_Foot	Tarsal_Bone	Cuneiform Bone of the Foot
C32417	Cuneiform_Cartilage	Laryngeal_Cartilage	Cuneiform Cartilage
C32418	Curved_Tube	Kidney_Part	Curved Tube
C32419	Cutaneous_Muscle	Muscle	Cutaneous Muscle
C32420	Cymba_Conchae	Ear_Part	Cymba Conchae
C32421	Cystic_Duct	Extrahepatic_Bile_Duct	Cystic Duct
C32422	Cystic_Vein	Vein	Cystic Vein
C32423	Cytoplasmic_Inclusion	Cell_Part	Cytoplasmic Inclusion
C32424	Cytoplasmic_Matrix	Cell_Part	Cytoplasmic Matrix|Cell Matrix|Cytomatrix|Ground Substance|Ground Substance Cytosol	A fluid cytoplasmic substance filling the interstices of the cytoskeleton. (On-line Medical Dictionary)
C32425	Decidua	Female_Reproductive_System_Part	Decidua|Decidua Graviditas
C32426	Decidua_Basalis	Other_Embryologic_Structure	Decidua Basalis
C32427	Decidua_Capsularis	Decidua	Decidua Capsularis
C32428	Decidua_Parietalis	Decidua	Decidua Parietalis
C32429	Decidual_Cell	Cell	Decidual Cell	An endometrial fibroblast that differentiates during pregnancy in response to the implanting embryo by accumulating lipid and glycogen. It is polygonal, possesses a large, vesicular nucleus and is believed to secrete placental prolactin. The decidual cells form a tightly adherent, massive cellular matrix that first surrounds the implanting embryo and later occupies most of the endometrium.
C32430	Deep_Abdominal_Muscle	Abdominal_Muscle	Deep Abdominal Muscle
C32431	Deep_Cervical_Lymph_Node	Cervical_Lymph_Node	Deep Cervical Lymph Node
C32432	Deep_Circumflex_Iliac_Artery	External_Iliac_Artery_Branch	Deep Circumflex Iliac Artery
C32433	Deep_Epigastric_Artery	External_Iliac_Artery_Branch	Deep Epigastric Artery
C32434	Deep_Epigastric_Vein	Deep_Vein	Deep Epigastric Vein
C32435	Deep_Fascia	Fascia	Deep Fascia
C32436	Deep_Femoral_Artery	Common_Femoral_Artery_Branch	Deep Femoral Artery|Profunda Femoris
C32437	Deep_Femoral_Artery_Branch	Artery	Deep Femoral Artery Branch
C32438	Deep_Intracranial_Venous_System	Intracranial_Venous_System	Deep Intracranial Venous System
C32439	Deep_Lymphatic_Vessel	Lymphatic_Vessel	Deep Lymphatic Vessel
C32440	Deep_Middle_Cerebral_Vein	Vein	Deep Middle Cerebral Vein
C32441	Deep_Palmar_Artery	Ulnar_Artery_Branch	Deep Palmar Artery
C32442	Deep_Palmar_Fascia	Deep_Fascia|Palmar_Fascia	Deep Palmar Fascia
C32443	Deep_Palmar_Vein	Deep_Vein	Deep Palmar Vein
C32444	Deep_Vein	Systemic_Vein	Deep Vein
C32446	Deltoid	Muscle	Deltoid
C32447	Dendrite	Nervous_System_Part	Dendrite
C32448	Dendritic_Tree	Retired_Concepts	Dendritic Tree
C32449	Dendrodendritic_Synapse	Synapse	Dendrodendritic Synapse
C32450	Dense_Connective_Tissue	Connective_Tissue_Proper	Dense Connective Tissue
C32451	Dental_Pulp	Tooth_Tissue	Dental Pulp	A richly vascularized and innervated connective tissue of mesodermal origin contained in the central cavity of a tooth and delimited by the dentin. It has formative, nutritive, sensory, and protective functions.
C32452	Dentate_Gyrus	Brain_Part	Dentate Gyrus
C32453	Dentin	Tooth_Tissue	Dentin	The hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root. Dentin is harder and denser than bone but softer than enamel.
C32454	Descemet_s_Membrane	Membrane	Descemet's Membrane	A thin hyaline membrane between the chief part of the sclera and the endothelial layer of the cornea.
C32455	Descending_Aorta	Aortic_Segment	Descending Aorta
C32456	Descending_Limb_of_the_Henle_s_Loop	Kidney_Part	Descending Limb of Henle's Loop
C32457	Desmoplakin	Cell_Part	Desmoplakin
C32458	Diagonal_Branch_of_the_Anterior_Descending_Artery	Left_Coronary_Artery_Branch	Diagonal Branch of the Anterior Descending Artery
C32459	Diaphragma_Sellae	Central_Nervous_System_Part	Diaphragma Sellae
C32460	Diaphysis_of_the_Bone	Bone_Surface	Diaphysis of the Bone
C32461	Diarthrosis	Joint	Diarthrosis
C32462	Digastric_Muscle	Neck_Muscle	Digastric Muscle
C32463	Dilator_Pupillae_Muscle	Muscle	Dilator Pupillae Muscle
C32464	Dimeric_Tubulin_Molecule	Cell_Part	Dimeric Tubulin Molecule
C32465	Direct_Cerebellar_Tract	Spinal_Cord_Part	Direct Cerebellar Tract
C32466	Direct_Pyramidal_Tract	Spinal_Cord_Part	Direct Pyramidal Tract
C32467	Discontinuous_Capillary	Capillary	Discontinuous Capillary|Sinusoid|Sinusoidal Capillary
C32468	Distal_Connecting_Fiber	Cell_Part	Distal Connecting Fiber
C32469	Distal_Convoluted_Tubule	Kidney_Part	Distal Convoluted Tubule
C32470	Distal_Part_of_the_Lumen_of_the_Centriole	Cell_Part	Distal Part of the Lumen of the Centriole
C32471	Dorsal_Cochlear_Nucleus	Vestibular_Nucleus	Dorsal Cochlear Nucleus
C32472	Dorsal_Curve	Musculoskeletal_System_Part	Dorsal Curve
C32473	Dorsal_Horn_of_the_Spinal_Cord	Spinal_Cord_Part	Dorsal Horn of the Spinal Cord
C32474	Dorsal_Muscle_of_the_Back	Muscle	Dorsal Muscle of the Back
C32475	Dorsal_Nucleus_of_the_Vagus_Nerve	Brain_Part	Dorsal Nucleus of the Vagus Nerve
C32476	Dorsal_Region_of_Foot	Lower_Extremity_Part	Dorsal Region of Foot
C32477	Dorsal_Root_of_the_Spinal_Nerve	Spinal_Nerve_Root	Dorsal Root of the Spinal Nerve
C32478	Dorsalis_Pedis_Artery	Artery	Dorsalis Pedis Artery
C32479	Dorsalis_Pedis_Artery_Branch	Artery	Dorsalis Pedis Artery Branch
C32480	Dorsomedial_Nucleus_of_the_Thalamus	Brain_Part	Dorsomedial Nucleus of the Thalamus
C32481	Dorsum	Musculoskeletal_System_Part	Dorsum
C32482	Dorsum_of_the_Tongue	Organ_of_Special_Sense_Part	Dorsum of the Tongue
C32484	Duct_of_the_Epididymis	Duct	Duct of the Epididymis
C32485	Duct_of_the_Gartner	Duct	Duct of Gartner
C32486	Duct_Salivary_Gland_System	Salivary_Gland_Tissue	Duct Salivary Gland System	The portion of the salivary system that conveys the saliva produced in the acinar salivary gland system to the oral cavity. The duct salivary gland system includes the ductus parotideus, ductus submandibularis, ductus sublingualis major, and ductus sublinguales minores, as well as the ducts from the minor salivary glands.
C32487	Ductus_Santorini	Duct	Ductus Santorini|Ductus Pancreaticus Accessorius
C32488	Dura_Mater	Membrane_of_the_Brain_or_Spinal_Cord	Dura Mater|Dura	Dura mater - the outermost, toughest, and most fibrous of the three membranes (meninges) that surround and protect the brain and spinal cord.
C32489	Early_Endosome	Endosome	Early Endosome|CURL|Compartment of Uncoupling Receptors and Ligands|Compartment of the Uncoupling Receptors and Ligands
C32490	Eccrine_Sweat_Gland	Sweat_Gland	Eccrine Sweat Gland
C32491	Ectocervical_Os	Female_Reproductive_System_Part	Ectocervical Os|Exocervical Os
C32492	Efferent_Ductule	Male_Reproductive_System_Part	Efferent Ductule
C32493	Ejaculatory_Duct	Duct	Ejaculatory Duct
C32494	Elastic_Cartilage	Cartilagenous_Tissue	Elastic Cartilage
C32495	Elastic_Fiber	Connective_Tissue_Fiber	Elastic Fiber
C32496	Elastin_Fiber	Skin_Part	Elastin Fiber
C32497	Elbow_Joint	Joint_By_Site	Elbow Joint
C32498	Electrical_Synapse	Synapse	Electrical Synapse	A synapse in which electrical connection is made directly through the cytoplasm, via gap junctions. (On-line Medical Dictionary)
C32499	Electron-dense_Plasma_Membrane_Layer	Cell_Part	Electron-Dense Plasma Membrane Layer
C32500	Electron-lucent_Plasma_Membrane_Layer	Cell_Part	Electron-Lucent Plasma Membrane Layer
C32501	Electron-transport_Chain_of_the_Respiratory_Enzymes	Cell_Part	Electron-Transport Chain of the Respiratory Enzymes
C32502	Elementary_Particles	Cell_Part	Elementary Particles
C32503	Ellipsoid_Portion_of_the_Inner_Segment_of_the_Photoreceptor_Cell	Eye_Part	Ellipsoid Portion of the Inner Segment of the Photoreceptor Cell
C32504	Embryonic_Connective_Tissue	Embryonic_Tissue	Embryonic Connective Tissue
C32505	Enamel	Tooth_Tissue	Enamel	A hard, thin, translucent layer of calcified substance that envelops and protects the dentin of the crown of the tooth. It is the hardest substance in the body and is almost entirely composed of calcium salts.
C32506	Endocrine_Cell_and_Neuroendocrine_Cell	Epithelial_Cell|Secretory_Cell	Endocrine Cell
C32508	Endocrine_Ovary	Endocrine_Sex_Organ	Endocrine Ovary
C32509	Endocrine_Pancreas	Endocrine_Gland	Endocrine Pancreas
C32510	Endocrine_Sex_Organ	Endocrine_Gland	Endocrine Sex Organ
C32511	Endocrine_Testis	Endocrine_Sex_Organ	Endocrine Testis
C32512	Endocytotic_Vesicle	Transport_Vesicle	Endocytotic Vesicle
C32513	Endolymph	Otolymph	Endolymph
C32514	Endometrial_Cavity	Cavity|Female_Reproductive_System_Part	Endometrial Cavity
C32515	Endometrial_Cell	Glandular_Cell	Endometrial Glandular Cell	An epithelial cell lining the endometrial cavity, located in the uterus. These cells proliferate and respond to the cyclic variations of estrogen and progesterone.  They synthesize or transport and secrete substances essential for survival and development of the embryo/fetus and associated extraembryonic membranes.
C32516	Endometrial_Stroma	Female_Reproductive_System_Part	Endometrial Stroma
C32517	Endomysium	Musculoskeletal_System_Part	Endomysium
C32518	Endoneurium	Connective_Tissue_Component_of_the_Peripheral_Nerve	Endoneurium
C32519	Endosome	Membranous_Cytoplasmic_Organelle	Endosome
C32520	Endosome_Proton	Cell_Part	Endosome Proton|Endosome Proton Pump|H+ Pump
C32521	Endosteal_Cell	Bone_Cell	Endosteal Cell	A cell lining the medullary cavity of bone.
C32522	Endothelium_of_the_Glomerular_Capillary	Endothelium	Endothelium of the Glomerular Capillary
C32523	Eparterial_Branch	Respiratory_System_Part	Eparterial Branch of the Right Main Bronchus
C32524	Epidermal_Ridges	Skin_Part	Epidermal Ridges|Epidermal Ridge|Rete Ridges
C32525	Epigastric_Region	Body_Region	Epigastric Region
C32526	Epiglottic_Cartilage	Laryngeal_Cartilage	Epiglottic Cartilage
C32527	Epimysium	Musculoskeletal_System_Part	Epimysium
C32528	Epineurium	Connective_Tissue_Component_of_the_Peripheral_Nerve	Epineurium
C32529	Epiphysis_of_the_Bone	Bone_Surface	Epiphysis of the Bone
C32530	Epithelial_Cell_Junction	Cell_Junction	Epithelial Cell Junction
C32531	Epithelial_Microvillus	Epithelium_Part	Epithelial Microvillus
C32532	Epithelial_Plica	Epithelium_Part	Epithelial Plica
C32533	Epitympanic_Recess	Ear_Part	Epitympanic Recess|Attic
C32534	Erector_Muscle_of_the_Hair	Cutaneous_Muscle	Erector Muscle of the Hair|Erector Muscle of Hair|Pilor Erectus
C32535	Esophageal_Artery	Thoracic_Aorta_Branch	Esophageal Artery
C32536	Esophageal_Gland	Exocrine_Gland	Esophageal Gland
C32537	Esophageal_Glandular_Cell	Glandular_Cell	Esophageal Glandular Cell	An epithelial cell that covers the lower third of the esophageal lumen. It is also found in the submucosal glands of the esophagus.
C32538	Esophageal_Mucosa	Esophageal_Tissue|Mucosa	Esophageal Mucosa
C32539	Esophageal_Muscular_Coat	Esophageal_Tissue	Esophageal Muscular Coat
C32540	Esophageal_Muscularis_Mucosa	Esophageal_Mucosa|Muscularis_Mucosa	Esophageal Muscularis Mucosa
C32541	Esophageal_Opening	Diaphragm_Part	Esophageal Opening
C32542	Esophageal_Squamous_Cell	Squamous_Cell	Esophageal Squamous Cell	A flat, scale-like epithelial cell that lines the upper and middle third of the esophageal lumen.
C32543	Esophageal_Tissue	Tissue	Esophageal Tissue
C32544	Eustachian_Valve	Cardiac_Valve	Eustachian Valve
C32545	Excitatory_Synapse	Chemical_Synapse	Excitatory Synapse	A synapse in which the firing of the presynaptic cell increases the probability of firing of the postsynaptic cell. (On-line Medical Dictionary)
C32546	Exocrine_Pancreas	Exocrine_Gland	Exocrine Pancreas
C32547	External_Abdominal_Ring	Superficial_Abdominal_Muscle	External Abdominal Ring
C32548	External_Anal_Sphincter	Gastrointestinal_Sphincter	External Anal Sphincter
C32549	External_Canal	Semicircular_Canal	External Canal|Horizontal Canal
C32550	External_Capsule	Brain_Part|Organ_Capsule	External Capsule
C32551	External_Carotid_Artery	Carotid_Artery|Common_Carotid_Artery_Branch	External Carotid Artery
C32552	External_Carotid_Artery_Branch	Artery	External Carotid Artery Branch
C32553	External_Circumflex_Artery	Deep_Femoral_Artery_Branch	External Circumflex Artery
C32554	External_Cuneiform_Bone_of_the_Foot	Cuneiform_Bone_of_the_Foot	External Cuneiform Bone of the Foot
C32555	External_Elastic_Membrane	Membrane	External Elastic Membrane	A thin layer of fibrous tissue capable of stretching and contracting. It is part of the tunica media of the blood vessels.
C32556	External_Geniculate_Body	Geniculate_Body	External Geniculate Body
C32557	External_Granular_Layer	Cortical_Cell_Layer	External Granular Layer|Outer Granular Layer|Small Pyramidal Cell Layer	The second layer of the cerebral cortex, composed of many small pyramidal cells and granule cells with short axons.
C32558	External_Iliac_Artery	Common_Iliac_Artery_Branch	External Iliac Artery
C32559	External_Iliac_Artery_Branch	Artery	External Iliac Artery Branch
C32560	External_Iliac_Vein	Iliac_Vein	External Iliac Vein
C32561	External_Intercostal_Muscle	Intercostal_Muscle	External Intercostal Muscle
C32562	External_Jugular_Vein	Jugular_Vein	External Jugular Vein
C32563	External_Lateral_Ligament_of_the_Ankle	Ligament	External Lateral Ligament of the Ankle|Ankle Lateral Collateral Ligament|External Lateral Ligament of Ankle|Lateral Collateral Ligament of Ankle|Lateral Collateral Ligament of the Ankle
C32564	External_Maleolus	Musculoskeletal_System_Part	External Maleolus
C32565	External_Malleolar_Artery	Anterior_Tibial_Artery_Branch	External Malleolar Artery
C32566	External_Nose	Organ_of_Special_Sense_Part	External Nose|Nasus Externus
C32567	External_Oblique_Muscle	Superficial_Abdominal_Muscle	External Oblique Muscle|Descending Oblique Muscle
C32568	External_Parieto-occipital_Fissure	Parieto-occipital_Fissure	External Parieto-Occipital Fissure
C32569	External_Plantar_Artery	Artery	External Plantar Artery
C32570	External_Pterygoid_Muscle	Muscle_of_the_Mastication	External Pterygoid Muscle
C32571	External_Pyramidal_Cell_Layer	Cortical_Cell_Layer	External Pyramidal Cell Layer|Medium Pyramidal Cell Layer|Outer Pyramidal Cell Layer	The third layer of the cerebral cortex, composed of an inner zone of medium sized pyramid-shaped cells with a single apical dendrite extending outward toward the surface and several dendrites extending inward and an outer zone of larger pyramid shaped cells whose dendrites and axons extend beyond this layer.
C32572	Extraglomerular_Mesangial_Cell	Mesangial_Cell	Extraglomerular Mesangial Cell
C32573	Extrahepatic_Bile_Duct	Bile_Duct	Extrahepatic Bile Duct
C32574	Eye_Appendage	Head_and_Neck_Part	Eye Appendage
C32575	Eyebrow	Eye_Appendage	Eyebrow
C32576	Eyelash	Hair	Eyelash
C32577	Facet_Joint	Joint_By_Site	Facet Joint|Zygapophyseal Joint
C32578	Facial_Artery	External_Carotid_Artery_Branch	Facial Artery
C32579	Facial_Vein	Vein_of_the_Head_or_Neck	Facial Vein
C32580	Facies_Posterior_Lentis	Eye_Part	Facies Posterior Lentis
C32581	F-actin	Actin_Filament	F-actin|Filamentous Actin
C32582	Falciform_Ligament	Liver_Ligament	Falciform Ligament
C32583	False_Vocal_Cord	Vocal_Cord	False Vocal Cord|Ventricular Fold
C32584	Falx_Cerebelli	Central_Nervous_System_Part	Falx Cerebelli
C32585	Fascia_Lata	Fascia	Fascia Lata
C32586	Fascicle	Nervous_Tissue	Fascicle	A small bundle of nerve fibers that is more or less associated functionally.
C32587	Fasciculata_Zone	Endocrine_System_Part	Fasciculata Zone
C32588	Fast-twitch_Motor_Unit	Cell_Part	Fast-twitch Motor Unit
C32589	Female_Genital_System_Fluid_or_Secretion	Body_Fluid_or_Substance	Female Genital System Fluid or Secretion|Female Genital System Fluid and Secretion
C32590	Female_Prepuce	Female_Reproductive_System_Part|Prepuce	Female Prepuce
C32591	Female_Urethra	Urethra	Female Urethra
C32592	Femoral_Artery_Branch	Artery	Femoral Artery Branch
C32593	Fenestra_Ovalis	Ear_Part	Fenestra Ovalis
C32594	Fenestra_Rotunda	Ear_Part	Fenestra Rotunda
C32595	Fenestrated_Capillary	Capillary	Fenestrated Capillary
C32596	Fibrillin	Tissue_Part	Fibrillin
C32597	Fibrillin_Microfibrils	Tissue_Part	Fibrillin Microfibrils
C32598	Fibrin	Body_Fluid_or_Substance	Fibrin
C32599	Fibrocartilage	Cartilagenous_Tissue	Fibrocartilage
C32600	Fibrous_Astrocyte	Astrocyte	Fibrous Astrocyte	A neuroglial cell of ectodermic origin having long, thin, infrequently branched cytoplasmic processes containing numerous fibrillar structures. It is found mainly in the white matter of the brain.
C32601	Fibrous_Coat_of_the_Liver	Gastrointestinal_System_Part	Fibrous Coat of the Liver
C32602	Fifth_Ventricle	Ventricle_Brain	Fifth Ventricle|Cavity of Septum Pellucidum|Cavity of the Septum Pellucidum
C32603	Filament	Cell_Part	Cytoskeleton Filament|Cytoskeletal Filament|Filament
C32604	Filiform_Papilla	Papilla_of_the_Tongue	Filiform Papilla
C32605	Filopodia	Cell_Part	Filopodia
C32606	Fimbria	Brain_Part	Fimbria
C32607	Fimbriated_End_of_the_Fallopian_tube	Female_Reproductive_System_Part	Fimbriated End of the Fallopian Tube
C32608	Finger	Digit|Upper_Extremity_Part	Finger
C32609	Fingernail	Nail	Fingernail|Finger Nail
C32610	First_Portion_of_the_Duodenum	Gastrointestinal_System_Part	First Portion of the Duodenum|First Portion of Duodenum|Superior Portion of Duodenum|Superior Portion of the Duodenum
C32611	Fissure_of_the_Ductus_Venosus	Liver_Fissure	Fissure of the Ductus Venosus
C32612	Fissure_of_the_Gallbladder	Liver_Fissure	Fissure of the Gallbladder
C32613	Fissure_of_the_Inferior_Vena_Cava	Liver_Fissure	Fissure of the Inferior Vena Cava
C32614	Fissure_of_Rolando	Cerebral_Fissure	Fissure of Rolando
C32615	Fissure_of_Sylvius	Cerebral_Fissure	Fissure of Sylvius|Sylvian Fissure
C32616	Flat_Bone	Bone	Flat Bone
C32617	Floor_of_the_Fourth_Ventricle	Brain_Part	Floor of the Fourth Ventricle
C32618	Focal_Adhesion	Anchoring_Junction	Focal Adhesion
C32619	Foliate_Papilla	Papilla_of_the_Tongue	Foliate Papilla
C32620	Follicular_Ovarian_Cell	Cell	Follicular Ovarian Cell	A cell located in the epithelium of the ovarian follicles.
C32621	Fontanelle	Other_Embryologic_Structure	Fontanelle
C32622	Foot	Lower_Extremity_Part	Foot
C32623	Foot_Process	Kidney_Part	Foot Process|Pedicel
C32624	Foramen_Apicis_Dentis	Tooth_Tissue	Foramen Apicis Dentis	A minute opening at or near the apex of a root of a tooth, but on occasion located on the side of a root, which allows passage to the vascular, lymphatic and neural structures supplying the pulp. Sometimes the main opening branches near the apex to form two or more apical openings.
C32625	Foramen_of_Luschka	Brain_Part	Foramen of Luschka
C32626	Foramen_of_Magendie	Brain_Part	Foramen of Magendie
C32627	Foramen_of_Monroe	Brain_Part	Foramen of Monroe
C32628	Forearm	Upper_Extremity_Part	Forearm
C32629	Fossa_of_the_Antihelix	Fossa	Fossa of the Antihelix|Fossa Triangularis|Fossa of Antihelix
C32630	Fossa_of_the_Helix	Fossa	Fossa of the Helix|Fossa of Helix|Scapha
C32631	Fourth_Portion_of_the_Duodenum	Gastrointestinal_System_Part	Fourth Portion of the Duodenum|Ascending Portion of Duodenum|Ascending Portion of the Duodenum|Fourth Portion of Duodenum
C32632	Foveolar_Cell	Glandular_Cell	Foveolar Cell	An epithelial cell found in the glands of the gastric mucosa.
C32633	Free_Edge_of_the_Nail	Integumentary_System_Part	Free Edge of the Nail
C32634	Free_Ribosome	Ribosome	Free Ribosome
C32635	Frontal_Bone	Flat_Bone	Frontal Bone
C32636	Frontal_Gyrus	Cerebral_Gyrus	Frontal Gyrus
C32637	Frontal_Horn_of_the_Lateral_Ventricle	Brain_Part	Frontal Horn of the Lateral Ventricle
C32638	Frontal_Nerve	Peripheral_Nerve	Frontal Nerve
C32639	Frontal_Sulcus	Cerebral_Sulcus	Frontal Sulcus
C32640	Frontopolar_Artery	Anterior_Cerebral_Artery_Branch	Frontopolar Artery
C32641	FSH_Cell	Gonadotrope_Cell	FSH Cell	A basophilic cell of the anterior pituitary gland whose granules secrete follicle-stimulating hormone
C32642	Functional_Layer_of_the_Endometrium	Female_Reproductive_System_Part	Functional Layer of the Endometrium
C32643	Fundic_Gland	Exocrine_Gland	Fundic Gland|Gastric Gland
C32644	Fungiform_Papilla	Papilla_of_the_Tongue	Fungiform Papilla
C32645	Fusiform_Cell	Cell	Fusiform Cell	A cell with spindle-like morphologic characteristics..
C32646	G-actin	Actin_Filament	G-actin|Globular Actin
C32647	Gallbladder_Body	Gastrointestinal_System_Part	Gallbladder Body
C32648	Gallbladder_Fundus	Gastrointestinal_System_Part	Gallbladder Fundus
C32649	Gallbladder_Neck	Gastrointestinal_System_Part	Gallbladder Neck
C32650	Gamma-Tubulin	Tubulin	Gamma-Tubulin|Gamma Tubulin	Ubiquitous or widely expressed 51-kDa conserved Gamma-Tubulins (Tubulin Family) constitute a major essential component of microtubule organizing centers such as spindle poles or centrosomes that are likely involved in minus-end nucleation of microtubule assembly. (NCI)
C32651	Gamma-tubulin_Ring	Cell_Part	Gamma-Tubulin Ring
C32652	Ganglion_Cell_Layer	Eye_Part	Ganglion Cell Layer
C32653	Ganglionic_Layer	Cortical_Cell_Layer	Ganglionic Layer|Ganglionic Layer of the Cerebral Cortex|Inner Pyramidal Cell Layer|Internal Pyramidal Cell Layer|Large Pyramidal Cell Layer	The fifth layer of the cerebral cortex, composed of the largest pyramidal cells (Martinotti's cells and Betz's cells), and traversed by a layer of horizontally arranged fibers.
C32654	Gastric_Artery	Abdominal_Aorta_Branch	Gastric Artery
C32655	Gastric_Glandular_Cell	Glandular_Cell	Gastric Glandular Cell	A cell found in the gastric mucosa that produces and secretes digestive enzymes and acid.
C32656	Gastric_Mucosa	Gastric_Tissue|Mucosa	Gastric Mucosa
C32657	Gastric_Muscular_Coat	Gastric_Tissue	Gastric Muscular Coat
C32658	Gastric_Muscularis_Mucosa	Gastric_Mucosa|Muscularis_Mucosa	Gastric Muscularis Mucosa
C32659	Gastric_Pit	Gastrointestinal_System_Part	Gastric Pit|Gastric Foveola
C32660	Gastric_Rugae	Gastrointestinal_System_Part	Gastric Rugae
C32661	Gastric_Secretion	Gastrointestinal_Fluid_or_Secretion	Gastric Secretion
C32662	Gastric_Serosal_Surface	Anatomic_Surface|Gastric_Tissue|Serosa	Gastric Serosal Surface
C32663	Gastric_Submucosa	Gastric_Tissue|Submucosa	Gastric Submucosa
C32664	Gastric_Tissue	Tissue	Gastric Tissue
C32665	Gastric_Vein	Vein	Gastric Vein
C32666	Gastrocnemius_Muscle	Muscle	Gastrocnemius Muscle
C32667	Gastrocolic_Ligament	Ligament	Gastrocolic Ligament
C32668	Gastroesophageal_Junction	Gastrointestinal_System_Part	Gastroesophageal Junction
C32669	Gastrointestinal_Sphincter	Gastrointestinal_System_Part|Muscle	Gastrointestinal Sphincter
C32670	Gastrophrenic_Ligament	Ligament	Gastrophrenic Ligament
C32671	Gastrosplenic_Omentum	Omentum	Gastrosplenic Omentum
C32672	G-Cell_of_the_Pancreas	Retired_Concepts	G-Cell of the Pancreas
C32673	Geniculate_Body	Brain_Part	Geniculate Body
C32674	Genito-urinary_Region	Body_Region	Genito-Urinary Region
C32675	Genu_of_the_Corpus_Callosum	Brain_Part	Genu of the Corpus Callosum
C32676	Germinal_Epithelium	Simple_Epithelium	Germinal Epithelium
C32677	Gingiva	Tissue	Gingiva|Gum	The mucous membrane-covered tissue of the jaws that surrounds the bases of the teeth.
C32678	Gland_of_Krause	Lacrimal_Gland	Gland of Krause
C32679	Gland_of_Moll	Apocrine_Sweat_Gland	Gland of Moll
C32680	Gland_of_Wolfring	Lacrimal_Gland	Gland of Wolfring
C32681	Glans_Clitoris	Female_Reproductive_System_Part	Glans Clitoris
C32682	Glenoid_Fossa	Fossa	Glenoid Fossa
C32683	Glomerular_Basement_Membrane	Membrane	Glomerular Basement Membrane|GBM	A sheet of amorphous extracellular material upon which the basal surfaces of epithelial cells rest and is the covering surface of a glomerular capillary, interposed between the cellular elements and the underlying connective tissue.
C32684	Glomerular_Capillary	Capillary	Glomerular Capillary
C32685	Glomerular_Mesangial_Cell	Mesangial_Cell	Glomerular Mesangial Cell	Cells found within the glomerular lobules of mammalian kidney, where they serve as structural supports, may regulate blood flow, are phagocytic and may act as accessory cells, presenting antigen in immune responses. (On-line Medical Dictionary)
C32686	Glomeruloza_Zone	Endocrine_System_Part	Glomerulosa Zone
C32688	Gluteal_Artery	Internal_Iliac_Artery_Branch	Gluteal Artery
C32689	Glycocalyx	Cell_Part	Glycocalyx
C32690	Glycogen_Inclusion	Cytoplasmic_Inclusion	Glycogen Inclusion
C32691	Gonadotrope_Cell	Glandular_Cell	Gonadotrope Cell
C32692	Graafian_Follicle	Ovarian_Follicle	Graafian Follicle|Mature Follicle
C32693	Granulosa_Lutein_Cell	Lutein_Cell|Ovarian_Granulosa_Cell	Granulosa Lutein Cell	A cell of the corpus luteum of the ovary that is derived from the granulosa cells of the preovulatory follicle; it secretes progesterone and estrogen.
C32694	Gray_Commissure	Commissure	Gray Commissure
C32695	Gray_Matter	Nervous_Tissue	Gray Matter	The nerve tissue composed of nerve cell bodies, unmyelinated nerve fibers and supportive tissue found in the brain and spinal cord. It is differentiated from the white matter by color of the tissues and the presence of more myelinated nerve cells in the white matter.
C32696	Gray_Matter_of_the_Spinal_Cord	Gray_Matter|Spinal_Cord_Part	Gray Matter of the Spinal Cord	The nervous tissue found in that part of the central nervous system that is lodged in the vertebral canal. It contains fewer myelinated fibers, but more nerve cell bodies, unmyelinated nerve fibers and blood vessels than the white matter.
C32697	Greater_Omentum	Omentum	Greater Omentum|Gastro-Colic Omentum
C32698	Great_Trochanter	Trochanter	Great Trochanter
C32700	Greater_Tuberosity	Musculoskeletal_System_Part	Greater Tuberosity
C32701	Ground_Substance	Tissue_Part	Ground Substance
C32702	Growing_Follicle	Ovarian_Follicle	Growing Follicle
C32703	Gyri_Breves_Insulae	Insula	Gyri Breves Insulae
C32704	Gyrus_Longus_Insulae	Insula	Gyrus Longus Insulae
C32705	Hair	Integumentary_System_Part	Hair
C32706	Hair_Bulb	Hair_Part	Hair Bulb
C32707	Hair_Follicle_Inferior_Segment	Hair_Part	Hair Follicle Inferior Segment
C32708	Hair_Follicle_Infundibulum	Hair_Part	Hair Follicle Infundibulum
C32709	Hair_Follicle_Isthmus	Hair_Part	Hair Follicle Isthmus
C32710	Hair_Papilla	Hair_Part	Hair Papilla
C32711	Hair_Root	Hair_Part	Hair Root
C32712	Hand	Upper_Extremity_Part	Hand	The distal portion of the upper extremity.  It consists of the carpus, metacarpus, and digits.
C32713	Haversian_Canal	Musculoskeletal_System_Part	Haversian Canal|Osteonal Canal
C32714	Haversian_System	Bone_Tissue	Haversian System|Osteon
C32716	Head_and_Neck_Muscle	Muscle	Head and Neck Muscle
C32717	Head_of_the_Epididymis	Male_Reproductive_System_Part	Head of the Epididymis
C32718	Head_of_the_Femur	Musculoskeletal_System_Part	Head of the Femur
C32719	Head_of_the_Fibula	Musculoskeletal_System_Part	Head of the Fibula
C32720	Head_of_the_Humerus	Musculoskeletal_System_Part	Head of the Humerus
C32722	Head_of_the_Tibia	Musculoskeletal_System_Part	Head of the Tibia
C32723	Helicotrema	Ear_Part	Helicotrema
C32724	Helix	Ear_Part	Helix|Auricle Helix
C32725	Hematopoietic_Cell	Cell	Hematopoietic and Lymphoid Cell	One of the cells of the blood, a leukocyte or erythrocyte.  SYN blood corpuscle.
C32726	Hemisphere_of_the_Cerebellum	Brain_Part	Hemisphere of the Cerebellum
C32727	Hemispheric_Cistern	Subarachnoid_Cistern	Hemispheric Cistern
C32728	Hemorrhoidal_Plexus	Deep_Vein	Hemorrhoidal Plexus
C32729	Hepatic_Artery	Abdominal_Aorta_Branch	Hepatic Artery
C32730	Hepatic_Duct	Bile_Duct	Hepatic Duct
C32732	Hepatic_Lobule	Hepatic_Tissue	Hepatic Lobule
C32733	Hepatic_Sinusoid	Hepatic_Tissue	Hepatic Sinusoid
C32734	Hepatic_Stellate_Cell	Cell	Hepatic Stellate Cell|Ito Cell	A star-shaped cell in the liver associated with the development of fibrosis. When stellate cells are activated in response to an injury, they proliferate and synthesize large amounts of extracellular matrix which results in deposition of scar or fibrous tissue.
C32735	Hepatic_Tissue	Hepatobiliary_Tissue	Hepatic Tissue|Hepatic Parenchyma
C32736	Hepatic_Vein	Deep_Vein	Hepatic Vein
C32737	Hepatogastric_Ligament	Ligament	Hepatogastric Ligament
C32738	Herring_Body	Endocrine_System_Part	Herring Body
C32739	High_Endothelial_Venule	Postcapillary_Venule	High Endothelial Venule
C32740	Hilar_Area_of_the_Kidney	Kidney_Part	Hilar Area of the Kidney|Hilar Area of Kidney|Hilum of Kidney|Hilum of the Kidney
C32741	Epencephalon	Brain_Part	Epencephalon
C32742	Hip_Joint	Joint_By_Site	Hip Joint
C32743	Hippocampal_Fissure	Cerebral_Fissure	Hippocampal Fissure|Dentate Fissure
C32744	Hippocampal_Sulcus	Brain_Part	Hippocampal Sulcus
C32745	Horizontal_Cell_of_Cajal	Fusiform_Cell|Neuron	Horizontal Cell of Cajal	A small fusiform neuroglial cell arranged horizontally in the molecular layer of the cerebral cortex.
C32746	Hyaline_Cartilage	Cartilagenous_Tissue	Hyaline Cartilage
C32747	Hydatid_of_Morgani	Male_Reproductive_System_Part	Hydatid of Morgani
C32748	Hydrophilic_Portion_of_the_Plasma_Membrane	Cell_Part	Hydrophilic Portion of the Plasma Membrane
C32749	Hydrophobic_Portion_of_the_Plasma_Membrane	Cell_Part	Hydrophobic Portion of the Plasma Membrane
C32750	Hymen	Female_Reproductive_System_Part	Hymen
C32751	Hyoepiglottic_Ligament	Laryngeal_Ligament	Hyoepiglottic Ligament
C32752	Hyoid_Bone	Irregular_Bone	Hyoid Bone
C32753	Hyoid_Muscle	Neck_Muscle	Hyoid Muscle
C32754	Hyparterial_Branch	Respiratory_System_Part	Hyparterial Branch of the Right Main Bronchus
C32755	Hypogastric_Region	Body_Region	Hypogastric Region
C32756	Hypoglossal_Triangle	Brain_Part	Hypoglossal Triangle|Trigonum Hypoglossi
C32757	Hypopharyngeal_Aspect_of_the_Aryteno-epiglottic_Fold	Head_and_Neck_Part	Hypopharyngeal Aspect of the Aryteno-Epiglottic Fold
C32758	Hypophyseal_Portal_Vein	Vein	Hypophyseal Portal Vein
C32759	Hypothalamohypophyseal_Portal_System	Portal_Venous_System	Hypothalamohypophyseal Portal System
C32760	Ileo-colic_Artery	Superior_Mesenteric_Artery_Branch	Ileo-Colic Artery
C32761	Iliac_Lymph_Node	Lymph_Node_by_Anatomic_Site	Iliac Lymph Node
C32762	Iliacus	Deep_Abdominal_Muscle	Iliacus
C32763	Iliocostal_Muscle	Muscle	Iliocostal Muscle
C32764	Iliopsoas_Muscle	Muscle	Iliopsoas Muscle
C32765	Ilium	Pelvic_Bone	Ilium
C32766	Immature_B-Lymphocyte	B-Lymphocyte|Immature_Lymphocyte	Immature B-Lymphocyte	A B-lymphocyte derived from a Pre B lymphocyte. It develops in bone marrow then exit via the central sinus. It goes through the vascular system to the spleen. It does not proliferate and differentiate in response to antigen, but instead responds to antigen by negative selection resulting in subsequent immune system tolerance to that antigen.
C32767	Immature_Bone	Bone_Tissue	Immature Bone|Bundle Bone|Nonlamellar Bone|Woven Bone	The earliest tissue to appear in embryonic development (it is the predominant bone in the developing fetus) and post fracture. The collagenous lamellae are randomly oriented and loosely intertwined. It is characterized by coarse fiber bundles approximately 30 um in diameter.
C32768	Immature_Centriole	Centriole	Immature Centriole
C32769	Incisor	Permanent_Tooth	Incisor
C32770	Incus	Auditory_Ossicle	Incus
C32771	Inferior_Anastomotic_Vein_of_the_Labbe	Vein	Inferior Anastomotic Vein of the Labbe|Inferior Anastomotic Vein of Labbe
C32772	Inferior_Cerebellopontine_Cistern	Lateral_Infratentorial_Cistern	Inferior Cerebellopontine Cistern|Lateral Cerebellomedullary Cistern
C32773	Inferior_External_Articular_Artery	Popliteal_Artery_Branch	Inferior External Articular Artery
C32774	Inferior_Frontal_Convolution	Brain_Part	Inferior Frontal Convolution
C32775	Inferior_Frontal_Gyrus	Frontal_Gyrus	Inferior Frontal Gyrus
C32776	Inferior_Frontal_Sulcus	Frontal_Sulcus	Inferior Frontal Sulcus
C32777	Inferior_Hypophyseal_Artery	Internal_Carotid_Artery_Branch	Inferior Hypophyseal Artery
C32778	Inferior_Internal_Articular_Artery	Popliteal_Artery_Branch	Inferior Internal Articular Artery
C32779	Inferior_Maxillary_Nerve	Peripheral_Nerve	Inferior Maxillary Nerve
C32780	Inferior_Mesenteric_Artery	Abdominal_Aorta_Branch	Inferior Mesenteric Artery
C32781	Inferior_Mesenteric_Artery_Branch	Artery	Inferior Mesenteric Artery Branch
C32782	Inferior_Mesenteric_Vein	Vein	Inferior Mesenteric Vein
C32783	Inferior_Oblique_Muscle	Oculomotor_Muscle	Inferior Oblique Muscle
C32784	Inferior_Occipital_Convolution	Brain_Part	Inferior Occipital Convolution
C32785	Inferior_Palpebral_Fold	Head_and_Neck_Part	Inferior Palpebral Fold
C32786	Inferior_Pancreatico-duodenal_artery	Superior_Mesenteric_Artery_Branch	Inferior Pancreatico-Duodenal Artery
C32787	Inferior_Parathyroid_Gland	Parathyroid_Gland	Inferior Parathyroid Gland
C32788	Inferior_Parietal_Convolution	Brain_Part	Inferior Parietal Convolution
C32789	Inferior_Profunda_Artery	Brachial_Artery_Branch	Inferior Profunda Artery
C32790	Inferior_Rectus_Muscle	Oculomotor_Muscle	Inferior Rectus Muscle
C32791	Inferior_Temporal_Convolution	Brain_Part	Inferior Temporal Convolution
C32792	Inferior_Temporal_Gyrus	Cerebral_Gyrus	Inferior Temporal Gyrus
C32793	Inferior_Temporal_Sulcus	Temporal_Sulcus	Inferior Temporal Sulcus
C32794	Inferior_Turbinate	Irregular_Bone	Inferior Turbinate
C32795	Inferior_Vena_Cava_Opening	Heart_Part	Inferior Vena Cava Opening
C32796	Inferior_Vermian_Artery	Vertebral_Artery_Branch	Inferior Vermian Artery
C32797	Infraspinatus	Rotator_Cuff	Infraspinatus
C32798	Infratentorial_Cistern	Subarachnoid_Cistern	Infratentorial Cistern
C32799	Infundibular_Cusp	Cardiac_Valve_Cusp	Infundibular Cusp
C32800	Infundibular_Segment_of_the_Fallopian_Tube	Female_Reproductive_System_Part	Infundibular Segment of the Fallopian Tube
C32801	Inguinal_Lymph_Node	Lymph_Node_by_Anatomic_Site	Inguinal Lymph Node
C32803	Inhibitory_Synapse	Chemical_Synapse	Inhibitory Synapse	A synapse in which the firing of the presynaptic cell reduces the probability of firing of the postsynaptic cell. (On-line Medical Dictionary)
C32804	Inner_Enamel_Epithelium	Epithelium	Inner Enamel Epithelium	The inner most layer of the enamel organ. It is derived from the ectoderm of the dental lamina and differentiates into ameloblasts that secrete the enamel of the root crown.
C32805	Inner_Hair_Cell_of_the_Organ_of_the_Corti	Hair_Cell	Inner Hair Cell of the Organ of the Corti|Inner Hair Cell of Organ of Corti	A cell situated on the inner most layer of the basilar membrane of the cochlea. Each cell has multiple, sensitive strands called stereocilia. In the resting state the stereocilia are leaning on each other in a conical bundle and touch the tectorial membrane. When the cochlea moves in response to sound, a slight shearing force occurs between the basilar and tectorial membranes, the stereocilia bend and send electrical impulses to the brain via the eighth cranial nerve.
C32806	Inner_Leaflet_of_the_Lipid_Bilayer	Cell_Part	Inner Leaflet of the Lipid Bilayer
C32807	Inner_Limiting_Membrane	Membrane	Inner Limiting Membrane	A retinal layer composed of the basal lamina of Muller's cells.
C32808	Inner_Nuclear_Layer	Eye_Part	Inner Nuclear Layer
C32809	Inner_Plexiform_Layer	Eye_Part	Inner Plexiform Layer
C32810	Inner_Rod_of_the_Corti	Ear_Part	Inner Rod of the Corti|Inner Rod of Corti
C32811	Inner_Segment_of_the_Photoreceptor_Cell	Eye_Part	Inner Segment of the Photoreceptor Cell
C32812	Inner_Supporting_Cell	Supporting_Cell_of_Organ_of_Corti	Inner Supporting Cell|Inner Phalangeal Cell	A tall, slender cell extending from the basilar membrane to the free surface of the organ of Corti. Each cell surrounds an inner hair cell.
C32813	Inner_Wall_of_the_Vestibule	Ear_Part	Inner Wall of the Vestibule
C32814	Innominate_Artery	Aortic_Arch_Branch	Innominate Artery
C32815	Innominate_Artery_Branch	Artery	Innominate Artery Branch
C32816	Innominate_Vein	Deep_Vein	Innominate Vein
C32817	Insula	Cerebral_Gyrus	Insula
C32818	Interatrial_Septum	Heart_Part	Interatrial Septum
C32819	Intercalated_Disk	Heart_Part	Intercalated Disk
C32820	Intercalated_Duct	Duct	Intercalated Duct
C32821	Intercostal_Artery	Thoracic_Aorta_Branch	Intercostal Artery
C32822	Intercostal_Artery_Branch	Artery	Intercostal Artery Branch
C32823	Intercostal_Fascia	Fascia	Intercostal Fascia
C32824	Intercostal_Muscle	Muscle	Intercostal Muscle|Respiratory Muscles
C32825	Intercostal_Nerve	Peripheral_Nerve	Intercostal Nerve
C32826	Interlobular_Artery	Artery	Interlobular Artery
C32827	Interlobular_Bile_Duct	Intrahepatic_Bile_Duct	Interlobular Bile Duct
C32828	Interlobular_Duct	Duct	Interlobular Duct
C32829	Intermediate_Fiber	Skeletal_Fiber	Intermediate Fiber
C32830	Intermediate_Line	Cell_Part	Intermediate Line|Intermediate Line of the Macula Adherens
C32831	Intermembrane_Space_of_the_Mitochondrion	Cell_Part	Intermembrane Space of the Mitochondrion
C32832	Internal_Abdominal_Ring	Superficial_Abdominal_Muscle	Internal Abdominal Ring
C32833	Internal_Anal_Sphincter	Gastrointestinal_Sphincter	Internal Anal Sphincter
C32834	Internal_Auditory_Artery	Basilar_Artery_Branch	Internal Auditory Artery|Labyrinthine Artery
C32835	Internal_Calcanean_Artery	Posterior_Tibial_Artery_Branch	Internal Calcanean Artery
C32836	Internal_Carotid_Artery	Carotid_Artery	Internal Carotid Artery
C32837	Internal_Carotid_Artery_Branch	Anterior_Circulation_Intracranial_Artery	Internal Carotid Artery Branch
C32838	Internal_Cerebral_Vein	Vein	Internal Cerebral Vein
C32839	Internal_Circumflex_Artery	Deep_Femoral_Artery_Branch	Internal Circumflex Artery
C32840	Internal_Cuneiform_Bone_of_the_Foot	Cuneiform_Bone_of_the_Foot	Internal Cuneiform Bone of the Foot
C32842	Internal_Elastic_Membrane	Membrane	Internal Elastic Membrane	A stretchable connective tissue membrane that is the outermost component of the tunica intima, delineating the border between the tunica media and the tunica intima.
C32843	Internal_Geniculate_Body	Geniculate_Body	Internal Geniculate Body
C32844	Internal_Granular_Layer	Cortical_Cell_Layer	Internal Granular Layer|Inner Granular Layer	The fourth layer of the cerebral cortex, composed of many densely packed granule cells with short axons and some small pyramidal cells, and traversed by a stria of horizontally arranged fibers. It contains neurites derived from cells of other layers and areas of the cerebral cortex and subcortical areas.
C32845	Internal_Iliac_Artery	Common_Iliac_Artery_Branch	Internal Iliac Artery
C32846	Internal_Iliac_Artery_Branch	Artery	Internal Iliac Artery Branch
C32847	Internal_Iliac_Vein	Iliac_Vein	Internal Iliac Vein
C32848	Internal_Intercostal_Muscle	Intercostal_Muscle	Internal Intercostal Muscle
C32849	Internal_Jugular_Vein	Jugular_Vein	Internal Jugular Vein
C32850	Internal_Lateral_Ligament_of_the_Ankle	Ligament	Internal Lateral Ligament of the Ankle
C32851	Internal_Lumen_of_the_Centriole	Cell_Part	Internal Lumen of the Centriole
C32852	Internal_Malleolar_Artery	Anterior_Tibial_Artery_Branch	Internal Malleolar Artery
C32853	Internal_Mammary_Lymph_Node	Lymph_Node_by_Anatomic_Site	Internal Mammary Lymph Node
C32854	Internal_Mammary_Vein	Deep_Vein	Internal Mammary Vein
C32855	Internal_Maxillary_Vein	Vein_of_the_Head_or_Neck	Internal Maxillary Vein
C32856	Internal_Nare	Organ_of_Special_Sense_Part	Internal Nare
C32857	Internal_Oblique_Muscle	Superficial_Abdominal_Muscle	Internal Oblique Muscle|Ascending Oblique Muscle
C32858	Internal_Occipital_Vein	Vein	Internal Occipital Vein
C32859	Internal_Parieto-occipital_Fissure	Parieto-occipital_Fissure	Internal Parieto-Occipital Fissure
C32860	Internal_Plantar_Artery	Artery	Internal Plantar Artery
C32861	Internal_Pterygoid_Muscle	Muscle_of_the_Mastication	Internal Pterygoid Muscle
C32862	Internal_Pubic_Artery	Internal_Iliac_Artery_Branch	Internal Pubic Artery
C32863	Internal_Wall_of_the_Tympanum	Ear_Part	Internal Wall of the Tympanum
C32864	Interosseous_Artery	Ulnar_Artery_Branch	Interosseous Artery
C32865	Interosseous_Vein	Deep_Vein	Interosseous Vein
C32866	Interpenduncular_Cistern	Anterior_Infratentorial_Cistern	Interpenduncular Cistern
C32867	Interphalangeal_Joint_of_the_Foot	Joint_By_Site	Interphalangeal Joint of the Foot
C32868	Interphalangeal_Joint_of_the_Hand	Joint_By_Site	Interphalangeal Joint of the Hand
C32869	Interphase_Cell	Cell	Interphase Cell|Non-dividing Cell|Resting Cell	A cell in a resting state. Individual chromosomes are not visible. The cell performs all biochemical and physiologic functions and replication of chromatin occurs.
C32870	Interstitial_Cell	Connective_and_Soft_Tissue_Cell	Interstitial Cell	An interstitial cell is a cell that is part of the connective and soft tissues.
C32871	Interstitial_Cell_of_Cajal	Smooth_Muscle_Tissue_Cell	Interstitial Cell of Cajal	A specialized cell found throughout the gastrointestinal tract. These cells are essential for normal gastrointestinal motility by functioning as the pacemaker cells in gastrointestinal muscles. They mediate or transduce inputs from enteric motor nerves to the smooth muscle syncytium.
C32872	Interstitial_Cell_of_the_Pineal_Gland	Interstitial_Cell	Interstitial Cell of the Pineal Gland	A non-neuronal cell that supports the pineal gland. It resembles an astrocyte and is found around blood vessels and among groups of pinealocytes. The nucleus is small, elongated and darkly stained.
C32873	Interstitial_Segment_of_the_Fallopian_Tube	Female_Reproductive_System_Part	Interstitial Segment of the Fallopian Tube
C32874	Interventricular_Septum	Heart_Part	Interventricular Septum
C32875	Intestinal_Secretion	Gastrointestinal_Fluid_or_Secretion	Intestinal Secretion
C32876	Intracellular_Membrane	Cellular_Membrane	Intracellular Membrane	A thin pliable sheet separating organelles from the protoplasm.
C32877	Intracranial_Venous_System	Venous_System	Intracranial Venous System
C32878	Intralaminar_Nucleus	Brain_Part	Intralaminar Nucleus
C32879	Intraparietal_Sulcus	Cerebral_Sulcus	Intraparietal Sulcus
C32880	Intra-thoracic_Lymph_Node	Thoracic_Lymph_Node	Intra-Thoracic Lymph Node
C32881	Irregular_Bone	Bone	Irregular Bone
C32882	Irregular_Dense_Connective_Tissue	Dense_Connective_Tissue	Irregular Dense Connective Tissue	Tissue characterized by a thick, random arrangement of collagen and elastin fibers with very few cells. The majority of the cells are fibroblasts, but mast cells and macrophages may also be seen. It is found in the dermis, periosteum, perichondrium, capsules of organs and sheaths of nerves and muscles.
C32883	Irregular_Tubule	Kidney_Part	Irregular Tubule
C32884	Ischium	Pelvic_Bone	Ischium|Hip
C32885	Islet_Cell	Endocrine_Cell_of_the_Gastrointestinal_System	Islet Cell	An Islet cell is a pancreatic cell that produces and secretes hormones such as insulin and glucagon.
C32886	Isthmic_Segment_of_the_Fallopian_Tube	Female_Reproductive_System_Part	Isthmic Segment of the Fallopian Tube
C32887	Thyroid_Gland_Isthmus	Endocrine_System_Part|Head_and_Neck_Part	Thyroid Gland Isthmus
C32888	Jaw_Joint	Joint_By_Site	Jaw Joint|Temporomandibular Joint
C32889	Joint_By_Site	Joint	Joint by Site
C32890	Joint_of_the_Pelvic_Girdle	Joint_By_Site	Joint of the Pelvic Girdle
C32891	Juxtaglomerular_Apparatus	Renal_Tissue	Juxtaglomerular Apparatus	Cellular population adjacent to the renal corpuscle, composed of the macula densa, the juxtaglomerular cells, and the extraglomerular mesangial cells. It regulates the blood pressure by activating the renin-angiotensin-aldosterone system.
C32892	Juxtamedullary_Nephron	Kidney_Part	Juxtamedullary Nephron
C32893	Karyosome	Heterochromatin	Karyosome
C32894	Kidney_Lower_Lobe	Kidney_Part	Kidney Lower Lobe|Lower Lobe of the Kidney
C32895	Kidney_Posterior_Surface	Kidney_Part	Kidney Posterior Surface
C32896	Kidney_Upper_Lobe	Kidney_Part	Kidney Upper Lobe|Upper Lobe of the Kidney
C32897	Kinocilium	Epithelium_Part	Kinocilium
C32898	Knee_Joint	Joint_By_Site	Knee Joint
C32899	L1_Vertebra	Lumbar_Vertebra	L1 Vertebra
C32900	L2_Vertebra	Lumbar_Vertebra	L2 Vertebra
C32901	L3_Vertebra	Lumbar_Vertebra	L3 Vertebra
C32902	L4_Vertebra	Lumbar_Vertebra	L4 Vertebra
C32903	L5_Vertebra	Lumbar_Vertebra	L5 Vertebra
C32904	Labial_Salivary_Gland	Minor_Salivary_Gland	Labial Salivary Gland
C32905	Lacrimal_Apparatus	Eye_Appendage	Lacrimal Apparatus
C32906	Lacrimal_Bone	Flat_Bone	Lacrimal Bone
C32907	Lacrimal_Canaliculus	Head_and_Neck_Part	Lacrimal Canaliculus
C32908	Lacrimal_Nerve	Peripheral_Nerve	Lacrimal Nerve
C32909	Lacrimal_Sac	Head_and_Neck_Part	Lacrimal Sac
C32910	Lactiferous_Duct	Duct|Mammary_Gland_Tissue	Lactiferous Duct	A channel conveying the milk secreted by the lobes of the breast to and through the nipple.
C32911	Lactotrope_Cell	Acidophilic_Cell	Lactotroph Cell|Lactotrope Cell|Lactotroph|Mammotrope|PRL Cell|Prolactin Cell
C32912	Lamella_of_Harvesian_System	Musculoskeletal_System_Part	Lamella of Harvesian System
C32913	Lamellar_Body	Respiratory_System_Part	Lamellar Body
C32914	Lamellipodia	Cell_Part	Lamellipodia
C32915	Lamina_Cinerea	Brain_Part	Lamina Cinerea
C32916	Lamina_Densa	Kidney_Part	Lamina Densa
C32917	Lamina_Lucida	Epithelium_Part	Lamina Lucida
C32918	Lamina_Propria	Mucosa	Lamina Propria	The connective tissue coat of a mucous membrane including the epithelium and basement membrane.
C32919	Lamina_Rara_Externa	Kidney_Part	Lamina Rara Externa
C32920	Lamina_Rara_Interna	Kidney_Part	Lamina Rara Interna
C32921	Lamina_Spiralis_Ossea	Ear_Part	Lamina Spiralis Ossea
C32922	Lamina_Terminalis_Cistern	Anterior_Supratentorial_Cistern	Lamina Terminalis Cistern
C32923	Large_Cleaved_Cell	Activated_Lymphocyte	Large Cleaved Cell	An activated lymphocyte with a diameter of about 12 micrometers, a nucleus with deep folds or clefts and clumped chromatin.
C32924	Large_Intestinal_Crypt_of_the_Lieberkuhn	Crypts_of_the_Lieberkuhn	Large Intestinal Crypt of Lieberkuhn
C32925	Large_Intestinal_Glandular_Cell	Enterocyte	Large Intestinal Glandular Cell	Intestinal enterocytes are low columnar to cuboidal cells comprising the majority of the epithelial tissue in the intestine and colon. They have both absorptive and secretory functions, absorbing water, sodium and short-chain fatty acids while secreting bicarbonate and potassium. Colonocytes originate from stem cells located at the base of the crypts. Enterocyte production, differentiation, and turnover occurs in topographically distinct regions of crypts. The transformation of colonic epithelial cells are frequently involved in colorectal cancers.
C32926	Large_Intestinal_Mucosa	Large_Intestinal_Wall_Tissue|Mucosa	Large Intestinal Mucosa	Mucosa consisting of the epithelium, basement membrane, lamina propria mucosae and lamina muscularis mucosae of the distal portion of the digestive tract from the small intestine to the anus.
C32927	Large_Intestinal_Muscular_Coat	Large_Intestinal_Wall_Tissue	Large Intestinal Muscular Coat	The portion of the intestinal covering that contracts causing peristalsis. It surrounds the weblike submucosa of the distal portion of the digestive tract from the small intestine to the anus.
C32928	Large_Intestinal_Muscularis_Mucosa	Large_Intestinal_Mucosa|Muscularis_Mucosa	Large Intestinal Muscularis Mucosa	The thin layer of smooth muscle fibers usually found as a part of the tunica mucosa deep to the lamina propria mucosae of the large intestine.
C32929	Large_Intestinal_Serosal_Surface	Anatomic_Surface|Large_Intestinal_Wall_Tissue|Serosa	Large Intestinal Serosal Surface	The membrane lining the external walls of the distal portion of the digestive tract from the small intestine to the anus. It consists of mesothelium on a connective tissue layer and it secretes a watery exudate.
C32930	Large_Intestinal_Submucosa	Large_Intestinal_Wall_Tissue|Submucosa	Large Intestinal Submucosa	The layer of areolar tissue situated beneath the mucous membrane in the distal portion of the digestive tract from the small intestine to the anus.
C32931	Large_Intestinal_Wall_Tissue	Tissue	Large Intestinal Wall Tissue	The tissue of the large intestine. It is composed of four layers - mucosa, submucosa, smooth muscle with inner circular and outer longitudinal layers, and serosa. The mucosa has a large number of goblet cells but does not have any villi. The longitudinal muscle layer is incomplete. The longitudinal muscle is limited to three distinct bands, called teniae coli that run the entire length of the colon. Contraction of the teniae coli exerts pressure on the wall and creates a series of pouches, called haustra, along the colon. Epiploic appendages, pieces of fat-filled connective tissue, are attached to the outer surface of the colon.
C32932	Large_Non-cleaved_Cell	Activated_B-Lymphocyte	Centroblast|Large Non-Cleaved Follicle Center Cell	An activated B-lymphocyte found in the germinal centers.  It has a large nucleus without clefts, finely dispersed chromatin, and a rim of basophilic cytoplasm.
C32933	Laryngeal_Ligament	Ligament	Laryngeal Ligament
C32934	Laryngeal_Muscle	Head_and_Neck_Muscle	Laryngeal Muscle
C32935	Laryngeal_Ventricle	Head_and_Neck_Part	Laryngeal Ventricle
C32936	Late_Endosome	Endosome	Late Endosome
C32937	Lateral_Domain_of_the_Epithelium	Epithelium_Part	Lateral Domain of the Epithelium
C32938	Lateral_Horn_of_the_Spinal_Cord	Spinal_Cord_Part	Lateral Horn of the Spinal Cord
C32939	Lateral_Infratentorial_Cistern	Infratentorial_Cistern	Lateral Infratentorial Cistern
C32940	Lateral_Lenticulostriate_Artery	Middle_Cerebral_Artery_Branch	Lateral Lenticulostriate Artery
C32941	Lateral_Ligament	Liver_Ligament	Lateral Ligament|Lateral Ligament of the Liver
C32943	Lateral_Orbitofrontal_Artery	Middle_Cerebral_Artery_Branch	Lateral Orbitofrontal Artery
C32944	Lateral_Posterior_Nucleus_of_the_Thalamus	Brain_Part	Lateral Posterior Nucleus of the Thalamus
C32945	Lateral_Rectus_Muscle	Oculomotor_Muscle	Lateral Rectus Muscle
C32946	Lateral_Sulcus_of_Sylvius	Cerebral_Sulcus	Lateral Sulcus of Sylvius
C32947	Lateral_Supratentorial_Cistern	Supratentorial_Cistern	Lateral Supratentorial Cistern|Parapeduncular Cistern
C32948	Lateral_Surface_of_the_Liver	Anatomic_Surface|Gastrointestinal_System_Part	Lateral Surface of the Liver|Lateral Surface of Liver|Right Surface of Liver|Right Surface of the Liver
C32949	Lateral_Surface_of_the_Prostate	Surface_of_the_Prostate	Lateral Surface of the Prostate
C32950	Lateral_Thyrohyoid_Ligament	Thyrohyoid_Ligament	Lateral Thyrohyoid Ligament
C32951	Lateral_Vestibular_Nucleus	Vestibular_Nucleus	Lateral Vestibular Nucleus
C32952	Lateral-occipital_Sulcus	Cerebral_Sulcus	Lateral-Occipital Sulcus
C32953	Layer_of_the_Ophthalmic_Nerve_Fibers	Eye_Part	Layer of the Ophthalmic Nerve Fibers
C32954	Layer_of_the_Rods_and_Cones	Eye_Part	Layer of the Rods and Cones|Layer of Rods and Cones
C32955	Left_Cerebral_Hemisphere	Cerebral_Hemisphere	Left Cerebral Hemisphere|Left Brain Hemisphere
C32956	Left_Common_Carotid_Artery	Aortic_Arch_Branch|Common_Carotid_Artery	Left Common Carotid Artery
C32957	Left_Common_Iliac_Artery	Common_Iliac_Artery	Left Common Iliac Artery
C32958	Left_Coronary_Artery_Branch	Coronary_Artery	Left Coronary Artery Branch
C32959	Left_Fallopian_Tube	Fallopian_Tube	Left Fallopian Tube
C32960	Left_Hepatic_Duct	Hepatic_Duct	Left Hepatic Duct
C32961	Left_Hypochondriac_Region	Hypochondrial_Region	Left Hypochondriac Region
C32962	Left_Inferior_Frontal_Convolution	Inferior_Frontal_Convolution	Left Inferior Frontal Convolution|Convolution of Broca
C32963	Left_Inguinal_Region	Inguinal_Region	Left Inguinal Region|Left Iliac Region
C32964	Left_Innominate_Vein	Innominate_Vein	Left Innominate Vein
C32965	Left_Lobe_of_the_Liver	Gastrointestinal_System_Part	Left Lobe of the Liver
C32966	Left_Lumbar_Region	Lumbar_Region	Left Lumbar Region
C32967	Left_Lung	Lung	Left Lung
C32968	Left_Main_Bronchus	Main_Bronchus	Left Main Bronchus
C32969	Left_Ovary	Ovary	Left Ovary
C32970	Left_Portion_of_the_Diaphragm	Diaphragm_Part	Left Portion of the Diaphragm
C32971	Left_Pulmonary_Artery	Pulmonary_Artery|Pulmonary_Artery_Branch	Left Pulmonary Artery
C32972	Left_Subclavian_Artery	Aortic_Arch_Branch|Subclavian_Artery	Left Subclavian Artery
C32973	Left_Thyroid_Gland_Lobe	Thyroid_Gland_Lobe	Left Thyroid Gland Lobe
C32974	Leg	Lower_Extremity_Part	Leg
C32975	Lens_Capsule	Organ_Capsule	Lens Capsule
C32976	Lens_Fiber	Eye_Part	Lens Fiber
C32977	Lenticular_Nucleus	Brain_Part	Lenticular Nucleus|Nucleus Lenticularis
C32978	Lentiform_Nucleus	Brain_Part	Lentiform Nucleus
C32979	Leptomeninges	Meninges	Leptomeninges	The two innermost layers of tissue that cover the brain and spinal cord, the arachnoid mater and the pia mater.
C32981	Lesser_Omentum	Omentum	Lesser Omentum|Gastro-Hepatic Omentum
C32982	Lesser_Trochanter	Trochanter	Lesser Trochanter|Lesser Trochanter of the Femur
C32983	Lesser_Tuberosity	Musculoskeletal_System_Part	Lesser Tuberosity|Lesser Tuberosity of the Humerus
C32984	Levator_Ani	Pelvic_Floor_Muscle	Levator Ani
C32985	LH_Cell	Gonadotrope_Cell	LH Cell	A luteinizing hormone secreting cell found in the anterior pituitary gland.
C32986	Ligamentum_Flavum	Ligament	Ligamentum Flavum
C32987	Lingual_Salivary_Gland	Minor_Salivary_Gland	Lingual Salivary Gland
C32988	Lingual_Tonsil	Tonsil	Lingual Tonsil
C32989	Lipid_Inclusion	Cytoplasmic_Inclusion	Lipid Inclusion|Fat Droplet
C32990	Lipoblast	Lipocyte	Lipoblast	A connective tissue cell that develops into a fat cell.
C32991	Lipocyte	Connective_and_Soft_Tissue_Cell	Lipocyte	A fat storing cell.
C32992	Liver_Acinus	Hepatic_Lobule	Liver Acinus	The smallest functional unit of the liver, comprising all of the liver parenchyma supplied by a terminal branch of the portal vein and hepatic artery; typically involves segments of two lobules lying between two terminal hepatic venules.
C32993	Liver_Acinus_Zone_1	Gastrointestinal_System_Part	Liver Acinus Zone 1|Zone 1|Zone 1 of Lliver Acinus|Zone 1 of the Lliver Acinus
C32994	Liver_Acinus_Zone_2	Gastrointestinal_System_Part	Liver Acinus Zone 2|Zone 2|Zone 2 of Lliver Acinus|Zone 2 of the Lliver Acinus
C32995	Liver_Acinus_Zone_3	Gastrointestinal_System_Part	Liver Acinus Zone 3|Zone 3|Zone 3 of Lliver Acinus|Zone 3 of the Lliver Acinus
C32996	Liver_Fissure	Gastrointestinal_System_Part	Liver Fissure
C32997	Liver_Ligament	Ligament	Liver Ligament
C32998	Lobar_Bronchus	Bronchus	Lobar Bronchus|Secondary Bronchus
C32999	Lobule_of_the_Auricle	Ear_Part	Lobule of the Auricle
C33000	Lobus_Caudatus	Gastrointestinal_System_Part	Lobus Caudatus|Caudal Lobe of the Cerebellum
C33001	Lobus_Quadratus	Gastrointestinal_System_Part	Lobus Quadratus|Quadrangular Lobule of the Cerebellum
C33002	Lobus_Spigelii	Gastrointestinal_System_Part	Lobus Spigelii
C33003	Long_Bone	Bone	Long Bone
C33004	Long_Saphenous_Vein	Saphenous_Vein	Long Saphenous Vein
C33005	Longitudinal_Fissure	Cerebral_Fissure	Longitudinal Fissure|Longitudinal Fissure of the Cerebrum
C33006	Loop_of_Henle	Kidney_Part	Henle's Loop|Loop of Henle
C33007	Loose_Connective_Tissue	Connective_Tissue_Proper	Loose Connective Tissue|Areolar Tissue	Irregular connective tissue, the intercellular matrix of which contains a sparse irregular network of collagen and elastic fiber bundles.
C33008	Low_Columnar_Cell	Columnar_Cell	Low Columnar Cell	A simple epithelial cell that is shaped like a short column.
C33009	Lower_Esophageal_Sphincter	Gastrointestinal_Sphincter	Lower Esophageal Sphincter|LES
C33010	Lower_Gastrointestinal_Tract	Gastrointestinal_System_Part	Lower Gastrointestinal Tract
C33011	Lower_Opening_of_the_Thorax	Opening_of_the_Thorax	Lower Opening of the Thorax
C33012	Lower_Respiratory_System	Respiratory_System_Part	Lower Respiratory System
C33013	Lumbar_Artery	Abdominal_Aorta_Branch	Lumbar Artery
C33014	Lumbar_Curve	Musculoskeletal_System_Part	Lumbar Curve
C33015	Lumbar_Nerve	Spinal_Nerve	Lumbar Nerve
C33016	Lumen_of_the_Endosome	Cell_Part	Lumen of the Endosome
C33017	Lumen_of_the_Lysosome	Cell_Part	Lumen of the Lysosome
C33018	Lumen_of_the_Peroxisome	Cell_Part	Lumen of the Peroxisome
C33019	Lunate_Sulcus	Cerebral_Sulcus	Lunate Sulcus
C33020	Lower_Lobe_of_the_Left_Lung	Lung_Lower_Lobe	Lower Lobe of the Left Lung|Lower Lobe of Left Lung-LLL|Lower Lobe of the Left Lung-LLL|Lung Left Lower Lobe
C33021	Upper_Lobe_of_the_Left_Lung	Lung_Upper_Lobe	Upper Lobe of the Left Lung|Lung Left Upper Lobe|Upper Lobe of Left Lung-LUL|Upper Lobe of the Left Lung-LUL
C33022	Lower_Lobe_of_the_Right_Lung	Lung_Lower_Lobe	Lower Lobe of the Right Lung|Lower Lobe of Right Lung -RLL|Lower Lobe of the Right Lung -RLL|Lung Right Lower Lobe
C33023	Upper_Lobe_of_the_Right_Lung	Lung_Upper_Lobe	Upper Lobe of the Right Lung|Lung Right Upper Lobe|Upper Lobe of Right Lung -RUL|Upper Lobe of the Right Lung -RUL
C33024	Lung_Tissue	Tissue	Lung Tissue|Lung Parenchyma	Tissue consisting of an external serous coat, subserous areolar tissue and lung parenchyma. The parenchyma is made up of lobules wound together by connective tissue. A primary lobule consists of a terminal bronchiole, respiratory bronchioles, and alveolar ducts, which communicate with many alveoli, each alveolus being surrounded by a network of capillary blood vessels.
C33025	Lunula	Integumentary_System_Part	Lunula
C33026	Lymph_Node_Afferent_Vessel	Lymph_Node_Part	Lymph Node Afferent Vessel
C33027	Lymph_Node_by_Anatomic_Site	Lymph_Node	Lymph Node by Anatomic Site
C33028	Lymph_Node_Capsule	Lymph_Node_Part|Organ_Capsule	Lymph Node Capsule
C33029	Lymph_Node_Cortex	Lymph_Node_Tissue|Lymphoid_Tissue	Lymph Node Cortex	The portion of the lymph node that contains nodules with germinal centers where B lymphocyte mature into plasma cells after activation. The nodules are separated by diffuse lymphatic tissue, lymph sinuses and trabeculae.
C33030	Lymph_Node_Efferent_Vessel	Lymph_Node_Part	Lymph Node Efferent Vessel
C33031	Lymph_Node_Hilum	Lymph_Node_Part	Lymph Node Hilum
C33032	Lymph_Node_Medullary_Portion	Lymph_Node_Tissue|Lymphoid_Tissue	Lymph Node Medullary Portion	The central portion of the lymph node. It is divided into sections by tracts of lymphatic tissue called medullary cords. Between the medullary cords are the medullary sinuses, which consist mainly of macrophages that engulf microorganisms as part of the lymph node's filtering function. Lymphocytes and plasma cells are also found in the medullary portion.
C33033	Lymph_Node_Sinus	Lymph_Node_Tissue|Sinus	Lymph Node Sinus	An irregular tortuous space within lymph nodes through which a continuous stream of lymph passes entering into the efferent lymphatic vessels.
C33034	Lymph_Node_Tissue	Lymph_Node_Part|Tissue	Lymph Node Tissue	Tissue composed of specialized cells that are organized as a definite organ, situated along the course of lymphatic vessels, and consisting of an outer cortical and an inner medullary part. The lymph nodes are the main source of lymphocytes of the peripheral blood and serve as a defense mechanism by removing noxious agents, such as bacteria and toxins, and probably play a role in antibody production.
C33035	Lymph_Node_Trabecula	Lymph_Node_Tissue	Lymph Node Trabecula|Lymph Node Trabeculae	The supporting and anchoring strand of connective tissue radiating out from the capsule through the interior of the lymph node.
C33037	Lymphatic_Capillary	Capillary|Lymphatic_Vessel	Lymphatic Capillary
C33038	Lymphatic_Vessel	Cardiovascular_System_Part	Lymphatic Vessel
C33040	Lymphoid_Follicle	Lymph_Node_Part	Lymphoid Follicle
C33041	Lymphokine-Activated_Natural_Killer_Cell	Activated_Natural-Killer_Cell	Lymphokine-Activated Natural Killer Cell	A natural killer cell, activated by a soluble cytokine released by a lymphocyte in response to an antigen. It is important in immune response.
C33042	Lysosome_Proton	Cell_Part	Lysosome Proton|H+ Pump|Lysosome Proton Pump
C33043	Macula_Densa	Kidney_Part	Macula Densa
C33044	Macula_Lutea	Eye_Part	Macula Lutea
C33045	Macula_of_Saccule	Ear_Part	Macula of Saccule
C33046	Macula_of_Utricle	Ear_Part	Macula of Utricle
C33047	Magendie_s_Foramen	Brain_Part	Magendie's Foramen
C33048	Male_Breast	Breast	Male Breast
C33049	Male_Prepuce	Male_Reproductive_System_Part|Prepuce	Male Prepuce|Foreskin
C33050	Male_Urethra	Urethra	Male Urethra
C33051	Malleus	Auditory_Ossicle	Malleus
C33052	Mamillary_Body	Brain_Part	Mamillary Body
C33053	Mantle_Zone	Lymph_Node_Part	Mantle Zone
C33054	Marginal_Chromatin	Heterochromatin	Marginal Chromatin
C33055	Marginal_Cusp	Cardiac_Valve_Cusp	Marginal Cusp
C33056	Marginal_Zone_of_Lymph_Node	Lymph_Node_Part	Marginal Zone of the Lymph Node|Marginal Zone of Lymph Node
C33057	Maturation-stage_Ameloblast	Ameloblast	Maturation-Stage Ameloblast	A short columnar epithelial cell that has deposited enamel and has lost organic material and water. It deposits calcium and phosphorus into the enamel matrix. The maturation-stage ameloblast produces and secretes small amounts of proteins.
C33058	Mature_B-Lymphocyte	B-Lymphocyte|Mature_Lymphocyte	Mature B-Lymphocyte|Mature B-Cell	A descendant of a lymphoid stem cell that differentiates into either a plasma cell or a memory B cell in response to a specific antigen. The mature B lymphocyte develops and differentiates in the bone marrow.
C33059	Mature_Bone	Bone_Tissue	Mature Bone|Lamellar Bone	A type of bone tissue. There are two subtypes of mature bone - compact and spongy. Compact bone is very dense and hard on the outside. Compact bone forms the thick-walled tube of the shaft of long bones and covers the epiphyses of long bones. Spongy bone is lightweight and consists of trabeculae, which branch and intersect to form a sponge like network, and red bone marrow for hematopoiesis. Short bones and the epiphyses of long bones consist mainly of spongy bone.
C33060	Mature_Centriole	Centriole	Mature Centriole
C33061	Mature_T-Lymphocyte	Mature_Lymphocyte|Peripheral_Post-Thymic_T-Lymphocyte	Mature T-Lymphocyte|Mature T-Cell	A lymphocyte derived from a pre T-lymphocyte in the thymus and stored in secondary lymphoid organs, bone marrow, and lymph nodes. It circulates in the bloodstream and the lymphatic system, where it searches for and attacks particular foreign or abnormal cells. A mature T lymphocyte has T cell receptors and other surface proteins on its cell surface.
C33062	Mature_Thymocyte	Thymocyte	Mature Thymocyte	A cell derived in the thymus from a T cell progenitor and then differentiates into a T-Lymphocyte.
C33063	Mechanoreceptor_Cell	Epithelial_Cell	Mechanoreceptor Cell|Auditory Receptor Cell
C33064	Medial_Collateral_Ligament_of_the_Knee	Ligament	Medial Collateral Ligament of the Knee
C33065	Medial_Golgi	Cell_Part	Medial Golgi
C33066	Medial_Lenticulostriate_Artery	Middle_Cerebral_Artery_Branch	Medial Lenticulostriate Artery
C33067	Medial_Orbitofrontal_Artery	Anterior_Cerebral_Artery_Branch	Medial Orbitofrontal Artery
C33068	Medial_Rectus_Muscle	Oculomotor_Muscle	Medial Rectus Muscle
C33069	Medial_Vestibular_Nucleus	Vestibular_Nucleus	Medial Vestibular Nucleus
C33070	Median_Basilic_Vein	Superficial_Vein	Median Basilic Vein
C33071	Median_Cephalic_Vein	Superficial_Vein	Median Cephalic Vein
C33072	Median_Vein	Superficial_Vein	Median Vein
C33073	Mediastinal_Lymph_Node	Lymph_Node_by_Anatomic_Site	Mediastinal Lymph Node
C33074	Medullary_Artery	Vertebral_Artery_Branch	Medullary Artery
C33075	Meibomian_Gland	Sebaceous_Gland	Meibomian Gland
C33077	Membrane_of_the_Brain_or_Spinal_Cord	Central_Nervous_System_Part|Membrane	Membrane of the Brain or Spinal Cord	The tissue that envelops the brain or spinal cord.
C33078	Membrane_of_Crista	Cell_Part	Membrane of Crista
C33079	Membrane_of_the_Endosome	Cell_Part	Membrane of the Endosome
C33080	Membrane_of_the_Golgi_Apparatus	Cell_Part	Membrane of the Golgi Apparatus
C33081	Membrane_of_the_Lysosome	Cell_Part	Membrane of the Lysosome
C33082	Membrane_of_the_Peroxisome	Cell_Part	Membrane of the Peroxisome
C33083	Vestibular_Membrane	Membrane	Membrane of Reissner|Vestibular Membrane	A thin layer of tissue that forms the anterior wall of the cochlear duct, which separates it from the vestibular canal.
C33084	Membrane_of_the_Rough_Endoplasmic_Reticulum	Cell_Part	Membrane of the Rough Endoplasmic Reticulum
C33085	Membrane_of_the_Smooth_Endoplasmic_Reticulum	Cell_Part	Membrane of the Smooth Endoplasmic Reticulum
C33086	Membrane-attached_Polyribosome	Ribosome	Membrane-Attached Polyribosome|Membrane-Attached Polysome
C33087	Membrane-attached_Ribosome	Ribosome	Membrane-Attached Ribosome
C33088	Membranous_Canal_of_the_Cochlea	Ear_Part	Membranous Canal of the Cochlea
C33089	Membranous_Cytoplasmic_Organelle	Cytoplasmic_Organelle	Membranous Cytoplasmic Organelle|Membrane-Limited Cytoplasmic Organelle
C33090	Membranous_Labyrinth	Ear_Part	Membranous Labyrinth
C33091	Membranous_Urethra	Urinary_System_Part	Membranous Urethra
C33093	Meningeal_Layer_of_the_Dura_Mater	Meninges	Meningeal Layer of the Dura Mater	The inner layer of the dura mater surrounding the brain. It is mostly fused with the outer layer, the endocranium that is adherent to the inner aspect of the cranial bones. These two layers form the dura mater. The latter covers and protects the brain and the spinal cord.
C33094	Meningeal_Nerve	Peripheral_Nerve	Meningeal Nerve
C33095	Meningothelial_Cell	Cell	Meningothelial Cell|Arachnoidal Cell
C33096	Meniscus	Cartilage	Meniscus
C33097	Meniscus_Lateralis	Meniscus	Meniscus Lateralis|Lateral Meniscus
C33098	Meniscus_Medialis	Meniscus	Meniscus Medialis|Medial Meniscus
C33099	Menses	Female_Genital_System_Fluid_or_Secretion	Menses
C33101	Mesangium	Renal_Tissue	Mesangium	A thin membrane in the central part of the renal glomerulus between capillaries. It helps to support the capillary loops in the glomerulus. Mesangial cells are phagocytic and for the most part separated from capillary lumina by endothelial cells.
C33102	Mesencephalic_Perforating_Artery	Posterior_Cerebral_Artery_Branch	Mesencephalic Perforating Artery
C33103	Mesentery	Body_Part	Mesentery
C33104	Mesothelial_Cell	Cell	Mesothelial Cell	A flat cell of mesenchymal origin that forms the superficial layer of the serosal membranes lining the body cavities of the abdomen and thorax.
C33105	Mesothelium	Tissue	Mesothelium	A simple layer of cells, derived from the mesoderm that lines the coelom or body cavity of the embryo. In the adult, it covers all true serous membranes (peritoneum, pericardium, pleura).
C33106	Metacarpophalangeal_Joint	Joint_By_Site	Metacarpophalangeal Joint
C33107	Metatarsal_Artery	Dorsalis_Pedis_Artery_Branch	Metatarsal Artery
C33108	Metatarsophalangeal_Joint	Joint_By_Site	Metatarsophalangeal Joint
C33109	Microcirculatory_Bed	Blood_Vessel	Microcirculatory Bed|Microvascular Bed
C33110	Microtrabecular_Strand	Cell_Part	Microtrabecular Strand
C33111	Microtubule_Triplet	Microtubule	Microtubule Triplet
C33112	Microvillus	Gastrointestinal_System_Part	Microvillus
C33113	Midcortical_Nephron	Kidney_Part	Midcortical Nephron|Intermediate Nephron
C33114	Middle_Cerebral_Artery_Branch	Internal_Carotid_Artery_Branch	Middle Cerebral Artery Branch
C33115	Middle_Constrictor_Muscle	Pharyngeal_Muscle	Middle Constrictor Muscle
C33116	Middle_Cuneiform_Bone_of_the_Foot	Cuneiform_Bone_of_the_Foot	Middle Cuneiform Bone of the Foot
C33117	Middle_Fossa	Fossa	Middle Fossa
C33118	Middle_Frontal_Convolution	Brain_Part	Middle Frontal Convolution
C33119	Middle_Frontal_Gyrus	Frontal_Gyrus	Middle Frontal Gyrus
C33120	Middle_Hemorrhoidal_Artery	Internal_Iliac_Artery_Branch	Middle Hemorrhoidal Artery
C33121	Middle_Inferior_Frontal_Convolution	Inferior_Frontal_Convolution	Middle Inferior Frontal Convolution|Pars Triangularis
C33123	Middle_Mediastinum	Mediastinum_Part	Middle Mediastinum
C33124	Middle_Occipital_Convolution	Brain_Part	Middle Occipital Convolution
C33125	Middle_Temporal_Convolution	Brain_Part	Middle Temporal Convolution
C33126	Middle_Temporal_Gyrus	Cerebral_Gyrus	Middle Temporal Gyrus
C33127	Middle_Temporal_Sulcus	Temporal_Sulcus	Middle Temporal Sulcus
C33128	Middle_Thyrohyoid_Ligament	Thyrohyoid_Ligament	Middle Thyrohyoid Ligament
C33129	Minor_Salivary_Gland	Salivary_Gland	Minor Salivary Gland
C33130	Minus_End_of_the_Actin_Filament	Cell_Part	Minus End of the Actin Filament|Minus End of Actin Filament|Pointed End of Actin Filament|Pointed End of the Actin Filament
C33131	Minus_End_of_the_Microtubule	Cell_Part	Minus End of the Microtubule|Minus End of Microtubule|Nongrowing End of Microtubule|Nongrowing End of the Microtubule
C33132	Mitochondrial_Crista	Cell_Part	Mitochondrial Crista
C33133	Mitochondrial_Matrix	Cell_Part	Mitochondrial Matrix
C33134	Mitochondrial_Matrix_Granule	Cell_Part	Mitochondrial Matrix Granule
C33135	Modiolus	Ear_Part	Modiolus|Columella
C33136	Molar_Tooth	Permanent_Tooth	Molar Tooth
C33137	Molecular_Layer	Cortical_Cell_Layer	Molecular Layer of the Cerebral Cortex|Plexiform Layer	The superficial layer of the cerebral cortex, containing nerve fibers, neuroglial cells, and occasional horizontal cells of Cajal.
C33138	Monocytoid_B-Cell	Mature_B-Lymphocyte	Monocytoid B-Lymphocyte|Monocytoid B-Cell	A lymphocyte derived most often from a pre-germinal center B cell, less often from a post-germinal center B cell. It is characterized by an abundant pale cytoplasm, indented nuclei with inconspicuous nucleoli, and open chromatin. It is found in the marginal zones of lymph nodes adjacent to the subcapsular and intermediary sinuses.
C33139	Mons_Pubis	Female_Reproductive_System_Part	Mons Pubis
C33140	Motor_Nucleus_of_the_Trigeminal_Nerve	Brain_Part	Motor Nucleus of the Trigeminal Nerve
C33141	Mucous_Salivary_Gland	Salivary_Gland	Mucous Salivary Gland
C33142	Multiform_Cell_Layer	Cortical_Cell_Layer	Multiform Cell Layer|Polymorphic Cell Layer	The innermost layer of the cerebral cortex. It consists of numerous small neurons, small pyramidal cells, stellate cells, especially superficially and fusiform cells in deeper part whose axons project into the white substance of the cerebral cortex hemisphere
C33143	Multipolar_Neuron	Neuron	Multipolar Neuron	A nerve cell with several processes, usually an axon and three or more dendrites.
C33144	Multivesicular_Body	Cell_Part	Multivesicular Body|MVB
C33145	Muscle_and_Fasciae_of_the_Thorax	Other_Anatomic_Concept	Muscle and Fasciae of the Thorax
C33146	Muscle_of_the_Coccyx	Muscle	Muscle of the Coccyx
C33147	Muscle_of_the_Mastication	Head_and_Neck_Muscle	Muscle of the Mastication|Muscle of Mastication
C33148	Muscle_of_the_Tympanum	Head_and_Neck_Muscle	Muscle of the Tympanum
C33149	Muscularis_Mucosa	Mucosa	Muscularis Mucosa	A thin layer of smooth muscle fibers found as a part of the tunica mucosa in the gastrointestinal tract and urinary bladder deep to the lamina propria mucosae.
C33150	Musculus_Latissimus_Dorsi	Muscle	Musculus Latissimus Dorsi
C33151	Myoblast	Muscle_Cell	Myoblast	A muscle cell precursor. It is essential for muscle repair.
C33152	Myoepithelial_Cell	Cell	Myoepithelial Cell|Basket Cell	A contractile cell found between the secretory cells and basement membrane of exocrine glands. Each myoepithelial cell has long cytoplasmic processes that wrap around a secretory unit. The contraction of the myoepithelial processes forces the secretory product from the secretory unit into its duct.
C33153	Myofibroblast	Connective_and_Soft_Tissue_Cell	Myofibroblast	A spindle-shaped cell that exhibits characteristics of both fibroblasts and smooth muscle cells. It has an elongated nucleus and does not have basal lamina. The cytoplasm can be distinguished from the surrounding matrix because of actin filaments, myosin and other muscle proteins arranged to suggest a contractile ability.
C33154	Myofilament	Musculoskeletal_System_Part	Myofilament
C33155	Myoid_Portion_of_the_Inner_Segment_of_the_Photoreceptor_Cell	Eye_Part	Myoid Portion of the Inner Segment of the Photoreceptor Cell
C33156	Nail	Integumentary_System_Part	Nail
C33157	Nasal_Bone	Flat_Bone	Nasal Bone
C33158	Nasal_Muscle	Head_and_Neck_Muscle	Nasal Muscle|Nasalis Muscle
C33159	Nasal_Nerve	Peripheral_Nerve	Nasal Nerve
C33160	Nasal_Septum	Musculoskeletal_System_Part	Nasal Septum
C33161	Nasolacrimal_Duct	Duct	Nasolacrimal Duct
C33162	Navicular_Bone	Tarsal_Bone	Navicular Bone
C33163	Neck_Muscle	Head_and_Neck_Muscle	Neck Muscle
C33164	Neck_of_the_Humerus	Musculoskeletal_System_Part	Neck of the Humerus
C33165	Nervi_Vascularis	Tissue_Part	Nervi Vascularis
C33166	Neural_Retina	Retina	Neural Retina|Retina Proper	A layer of nerve cells in the retina. Embryologically, it is part of the brain. Incoming light passes through nerve-fibres and intermediary nerve cells of the neural retina, before encountering the light-sensitive rods and cones at the interface between neural retina and the pigmented retinal epithelium.
C33167	Neurofilament-H	Neurofilament	Neurofilament-H|NF-H
C33168	Neurofilament-L	Neurofilament	Neurofilament-L|NF-L
C33169	Neurofilament-M	Neurofilament	Neurofilament-M|NF-M
C33170	Nissl_Body	Nervous_System_Part	Nissl Body
C33171	Node_of_Bizzozero	Skin_Part	Node of Bizzozero
C33172	Node_of_Ranvier	Nervous_System_Part	Node of Ranvier
C33173	Non-articular_Bone_Surface	Bone_Surface	Non-Articular Bone Surface
C33174	Nonmembranous_Cytoplasmic_Organelle	Cytoplasmic_Organelle	Nonmembranous Cytoplasmic Organelle
C33175	Nonphotosensitive_Region_of_the_Retina	Eye_Part	Nonphotosensitive Region of the Retina
C33176	Normal_Cell	Retired_Concepts	Normal Cell	A cell found naturally, in any part of the body that is free from disease.
C33177	Normal_Tissue	Retired_Concepts	Tissue|Normal Tissue	An anatomical structure, which consists of similarly specialized cells and intercellular matrix, aggregated according to genetically determined spatial relationships. Examples: epithelium, muscle tissue, connective tissue, neural tissue, lymphoid tissue.
C33178	Nostril	Organ_of_Special_Sense_Part	Nostril|External Nare
C33180	Nuclear_Lamin	Cell_Part	Nuclear Lamin
C33181	Nucleolar-Associated_Chromatin	Heterochromatin	Nucleolar-Associated Chromatin
C33182	Nucleolar_Fibrillar_Material	Cell_Part	Nucleolar Fibrillar Material|Pars Fibrosa
C33183	Nucleolar_Granular_Material	Cell_Part	Nucleolar Granular Material|Pars Granulosa
C33184	Nucleolonema	Cell_Part	Nucleolonema
C33185	Nucleus_of_the_Hypoglossal_Nerve	Retired_Concepts	Nucleus of the Hypoglossal Nerve
C33186	Nucleus_of_the_Mesencephalic_Tract_of_the_Trigeminal_Nerve	Brain_Part	Nucleus of the Mesencephalic Tract of the Trigeminal Nerve
C33187	Nucleus_of_the_Solitary_Tract	Retired_Concepts	Nucleus of the Solitary Tract|Nucleus of the Tractus Solitarius
C33188	Nucleus_of_the_Spinal_Tract_of_the_Trigeminal_Nerve	Brain_Part	Nucleus of the Spinal Tract of the Trigeminal Nerve
C33189	Nutrient_Artery	Brachial_Artery_Branch	Nutrient Artery
C33190	Obturator_Artery	Internal_Iliac_Artery_Branch	Obturator Artery
C33191	Obturator_Externus_Muscle	Obturator_Muscle	Obturator Externus Muscle
C33192	Obturator_Internus_Muscle	Obturator_Muscle	Obturator Internus Muscle
C33193	Obturator_Muscle	Muscle	Obturator Muscle
C33194	Occipital_Artery	External_Carotid_Artery_Branch	Occipital Artery
C33195	Occipital_Horn_of_the_Lateral_Ventricle	Brain_Part	Occipital Horn of the Lateral Ventricle
C33196	Occipital_Sulcus	Cerebral_Sulcus	Occipital Sulcus
C33197	Occipital-temporal_Gyrus	Cerebral_Gyrus	Occipital-Temporal Gyrus|Fusiform Gyrus
C33198	Occipito-frontalis_Muscle	Head_and_Neck_Muscle	Occipito-Frontalis Muscle
C33199	Oculomotor_Muscle	Head_and_Neck_Muscle	Oculomotor Muscle
C33200	Olecranon	Musculoskeletal_System_Part	Olecranon
C33201	Olfactory_Chemoreceptor	Nervous_System_Part	Olfactory Chemoreceptor
C33202	Olfactory_Cistern	Anterior_Supratentorial_Cistern	Olfactory Cistern
C33203	Olfactory_Epithelium	Epithelium	Olfactory Epithelium	An epithelium located in the roof, superior conchae, and septum of the nasal cavity. It is formed by ciliated olfactory receptor cells, supporting cells and basal cells. Olfactory glands in the epithelium produce and secrete mucus which forms a layer over the epithelium. The cilia of the receptor cells protrude into the mucous layer where molecular reception with odors occurs and sensory transduction begins.
C33204	Olfactory_Lobe	Brain_Part	Olfactory Lobe
C33205	Olfactory_Mucosa	Mucosa	Olfactory Mucosa	The part of the nasal mucosa composed of neuroepithelial tissue and mucus-producing Bowman's glands. The mucus moistens the epithelium and helps dissolve odor-containing gases.
C33206	Olfactory_Sulcus	Frontal_Sulcus	Olfactory Sulcus
C33207	Olfactory_Tract	Brain_Part	Olfactory Tract
C33209	Omentum	Body_Part	Omentum|Omental Fat
C33210	Oolemma	Cell_Part	Oolemma
C33211	Ooplasm	Cell_Part	Ooplasm
C33212	Opening_of_the_Antrum	Head_and_Neck_Part	Opening of the Antrum
C33213	Opening_of_the_Pulmonary_Vein	Heart_Part	Opening of the Pulmonary Vein
C33214	Opening_of_the_Vena_Cava	Diaphragm_Part	Opening of the Vena Cava|Foramen Quadratum|Opening of Vena Cava
C33215	Ophthalmic_Nerve	Peripheral_Nerve	Ophthalmic Nerve
C33216	Opthalmic_Artery	Internal_Carotid_Artery_Branch	Opthalmic Artery
C33217	Optic_Commissure	Brain_Part	Optic Commissure
C33218	Optic_Tract	Brain_Part	Optic Tract
C33219	Orbiculus_Ciliaris	Eye_Part	Orbiculus Ciliaris
C33220	Orbit_Disc	Musculoskeletal_System_Part	Orbit Disc
C33221	Orbital_Part_of_the_Inferior_Frontal_Gyrus	Brain_Part	Orbital Part of the Inferior Frontal Gyrus
C33222	Orbital_Sulcus	Frontal_Sulcus	Orbital Sulcus
C33223	Organ_of_Corti	Ear_Part	Organ of Corti|Spiral Organ of Corti
C33224	Organ_of_the_Special_Sense	Organ	Organ of Special Sense|Special Sense Organ
C33225	Orifice_of_the_Eustachian_Tube	Ear_Part	Orifice of the Eustachian Tube|Orifice of Auditory Tube|Orifice of Eustachian Tube|Orifice of the Auditory Tube
C33226	Orthodox_Configuration_of_the_Mitochondrion	Mitochondrion	Orthodox Configuration of the Mitochondrion
C33227	Osseous_Labyrinth	Ear_Part	Osseous Labyrinth|Bony Labyrinth
C33228	Osteoid	Bone_Tissue	Osteoid	A protein mixture secreted by osteoblasts. When the protein mixture mineralizes, it becomes bone. Osteoid is primarily composed of type 1 collagen.
C33229	Other_Body_Part	Other_Anatomic_Concept	Other Body Part
C33230	Otolith	Ear_Part	Otolith
C33231	Otolymph	Body_Fluid_or_Substance	Otolymph
C33232	Outer_Enamel_Epithelium	Epithelium	Outer Enamel Epithelium	Epithelium derived from the ectoderm of the dental lamina. It is found on the upper part of the bell or cap of the enamel organ of the developing tooth and is composed of cuboidal cells.
C33233	Outer_Hair_Cell_of_the_Organ_of_the_Corti	Hair_Cell	Outer Hair Cell of the Organ of the Corti|Outer Hair Cell of Organ of Corti	A cell situated on one of three of the most outer layers of the basilar membrane of the cochlea. Each cell has multiple, sensitive strands called stereocilia. In the resting state the stereocilia are leaning on each other in a conical bundle and are embedded in the tectorial membrane. When the cochlea moves in response to sound, a slight shearing force occurs between the basilar and tectorial membranes, the stereocilia bend and send electrical impulses to the brain via the eighth cranial nerve.
C33234	Outer_Leaflet_of_the_Lipid_Bilayer	Cell_Part	Outer Leaflet of the Lipid Bilayer
C33235	Outer_Limiting_Membrane	Membrane	Outer Limiting Membrane	A thin fenestrated layer of the pars nervosa retinae adjacent to the outer nuclear layer and through which extend the visual rods and cones.
C33236	Outer_Nuclear_Layer_of_Retina	Eye_Part	Outer Nuclear Layer of Retina|Outer Nuclear Layer of the Retina
C33237	Outer_Plexiform_Layer	Eye_Part	Outer Plexiform Layer|Outer Plexiform Layer of the Retina
C33238	Outer_Rod_of_the_Corti	Ear_Part	Outer Rod of the Corti|Outer Rod of Corti
C33239	Outer_Segment_of_the_Photoreceptor_Cell	Eye_Part	Outer Segment of the Photoreceptor Cell
C33240	Outer_Supporting_Cell	Supporting_Cell_of_Organ_of_Corti	Outer Supporting Cell|Outer Phalangeal Cell	A cell forming a cup for the outer hair cell of the Organ of Corti. The supporting cell sends out a narrow filament that angles towards the base of the cochlea. The structure is such that the supporting cell touches the outer hair cell only at the top and bottom.
C33241	Outer_Wall_of_the_Vestibule	Ear_Part	Outer Wall of the Vestibule|Outer Wall of Vestibule|Tympanic Wall of Vestibule|Tympanic Wall of the Vestibule
C33242	Ovarian_Artery	Abdominal_Aorta_Branch	Ovarian Artery
C33243	Ovarian_Cortex	Ovarian_Tissue	Ovarian Cortex	The outer layer of the ovary, composed of cellular connective tissue which contains the ovarian follicles.
C33244	Ovarian_Follicle	Female_Reproductive_System_Part	Ovarian Follicle
C33245	Ovarian_Medulla	Ovarian_Tissue	Ovarian Medulla	The central portion of the ovary, composed of loose connective tissue that contains blood vessels, lymph vessels and nerves.
C33246	Ovarian_Tissue	Endocrine_Reproductive_Tissue	Ovarian Tissue	Tissue comprised of specialized cells and intercellular matrix, aggregated according to genetically determined spatial relationships in order to carry out the functions of production and ovulation of oocytes and the production and secretion of hormones.
C33247	Palatal_Muscle	Head_and_Neck_Muscle	Palatal Muscle
C33248	Palate_Bone	Bone	Palate Bone
C33249	Palatine_Salivary_Gland	Minor_Salivary_Gland	Palatine Salivary Gland
C33250	Palatine_Tonsil	Tonsil	Palatine Tonsil
C33251	Palmar_Fascia	Fascia	Palmar Fascia
C33252	Palmar_Region	Body_Region	Palmar Region
C33254	Pancreatic_Centroacinar_Cell	Glandular_Cell	Pancreatic Centroacinar Cell	A cell with a centrally placed nucleus found in the proximal portion of pancreatic intercalated duct that protrudes into the acinus. It secretes bicarbonate made in the cell by the dissociation of carbonic acid in the presence of carbonic anhydrase II. These cells are thought to act as signal transducers, influencing the degranulation of the acinar cells.
C33255	Pancreatic_Endocrine_Secretion	Pancreatic_Secretion	Pancreatic Endocrine Secretion|Endocrine Pancreas Secretion
C33256	Pancreatic_Exocrine_Secretion	Pancreatic_Secretion	Pancreatic Exocrine Secretion|Exocrine Pancreas Secretion
C33258	Papilla_of_the_Tongue	Organ_of_Special_Sense_Part	Papilla of the Tongue
C33259	Papillary_Muscle	Muscle	Papillary Muscle
C33260	Parafascicular_Nucleus_of_the_Thalamus	Brain_Part	Parafascicular Nucleus of the Thalamus
C33261	Parafollicular_Cell	Neuroendocrine_Cell	C-Cell|Parafollicular Cell	A neuroendocrine cell found in the thyroid gland interspersed among the follicular cells or in clusters between the follicles. It produces and secretes calcitonin in response to its calcium receptor.
C33262	Parahippocampal_Gyrus	Cerebral_Gyrus	Parahippocampal Gyrus
C33263	Paranasal_Sinus_Retired	Retired_Concepts	Paranasal Sinus
C33264	Paranemin	Vimentin-like_Filament	Paranemin
C33265	Parathyroid_Gland_Capsule	Organ_Capsule	Parathyroid Gland Capsule
C33266	Parathyroid_Gland_Chief_Cell	Chief_Cell|Parathyroid_Gland_Parenchymal_Cell	Parathyroid Gland Chief Cell	The primary cell of the parathyroid gland. Its contains secretory granules, large Golgi complexes, and moderate numbers of mitochondria. It produces parathyroid hormone. The cells occur in sheets interspersed with areas of fatty tissue. Occasionally the cells are arranged in follicles.
C33267	Parathyroid_Gland_Clear_Cell	Clear_Cell|Parathyroid_Gland_Parenchymal_Cell	Parathyroid Gland Clear Cell	A large cell of the parathyroid gland. It has abundant clear cytoplasm packed with glycogen and a basal nucleus.
C33268	Parathyroid_Gland_Follicle	Parathyroid_Gland_Epithelial_Tissue	Parathyroid Gland Follicle	A follicle believed to be formed by degeneration of suppressed chief cells. Secretion of hormonal and/or other substances into intercellular spaces progressively forms follicular cavities.
C33269	Parathyroid_Gland_Oxyphil_Cell	Oxyphil_Cell|Parathyroid_Gland_Parenchymal_Cell	Parathyroid Gland Oxyphil Cell|Parathyroid Gland Oxyphilic Cell	A cell of the parathyroid gland that has condensed chromatin in a small round nucleus. Its cytoplasm is composed of tightly packed mitochondria and glycogen granules, with rare secretory granules, stains pink, and the margin is usually observed.
C33270	Parathyroid_Gland_Tissue	Tissue	Parathyroid Gland Tissue	Parathyroid gland tissue consists of three primary cell types - chief cells, oxyphil cells and clear cells. These glands are usually located in close proximity to the thyroid gland.
C33271	Parietal_Layer_of_Bowman_s_Capsule	Kidney_Part	Parietal Layer of Bowman's Capsule
C33272	Parietal_Part_of_the_Peritoneum	Membrane_Part	Parietal Part of the Peritoneum
C33273	Parietal_Pleura	Pleural_Tissue	Parietal Pleura	The outermost of the two pleural membranes. It consists of a thin basal layer of fibrous tissue upon which sits a continuous layer of mesothelial cells. The cells function to secrete the lubricant lining the pleural cavity.
C33274	Parieto-occipital_Artery	Posterior_Cerebral_Artery_Branch	Parieto-Occipital Artery
C33275	Parieto-occipital_Fissure	Cerebral_Fissure	Parieto-Occipital Fissure
C33276	Parieto-occipital_Sulcus	Cerebral_Sulcus	Parieto-Occipital Sulcus
C33277	Parotid_Duct	Duct	Parotid Duct|Stensen's Duct
C33278	Parotid_Gland_Lymph_Node	Head_and_Neck_Lymph_Node	Parotid Gland Lymph Node
C33279	Pars_Externa	Ear_Part	Pars Externa
C33280	Pars_Interna	Ear_Part	Pars Interna|Pars Interna of the External Acoustic Meatus
C33281	Pars_Media	Ear_Part	Pars Media|Pars Media of the External Acoustic Meatus
C33282	Patella	Bone_of_the_Lower_Extremity|Short_Bone	Patella
C33283	Patellar_Ligament	Ligament	Patellar Ligament
C33284	Pectoralis_Major	Pectoralis_Muscle	Pectoralis Major|Musculus Pectoralis Major
C33285	Pectoralis_Minor	Pectoralis_Muscle	Pectoralis Minor|Musculus Pectoralis Minor
C33286	Pectoralis_Muscle	Muscle	Pectoralis Muscle
C33287	Pelvic_Bone	Bone	Pelvic Bone
C33289	Pelvic_Curve	Musculoskeletal_System_Part	Pelvic Curve
C33290	Pelvic_Floor_Muscle	Abdominal_Muscle	Pelvic Floor Muscle
C33291	Pelvic_Girdle	Lower_Extremity_Part	Pelvic Girdle
C33292	Perforating_Artery	Deep_Femoral_Artery_Branch	Perforating Artery
C33293	Perforating_Canal	Musculoskeletal_System_Part	Perforating Canal|Volkmann's Canal
C33294	Periarteriolar_Lymphoid_Sheath	Spleen_Part	Periarteriolar Lymphoid Sheath|T-Cell Zone of Spleen|T-Cell Zone of the Spleen
C33295	Pericallosal_Artery	Anterior_Cerebral_Artery_Branch	Pericallosal Artery
C33296	Pericardiac_Artery	Thoracic_Aorta_Branch	Pericardiac Artery
C33297	Perilymph	Otolymph	Perilymph
C33298	Perimetrium	Anatomic_Surface|Female_Reproductive_System_Part	Perimetrium|Uterine Body Serosal Surface
C33299	Perimysium	Musculoskeletal_System_Part	Perimysium
C33300	Perineal_Muscle	Muscle	Perineal Muscle
C33301	Perineum	Body_Region	Perineum
C33302	Perineurium	Connective_Tissue_Component_of_the_Peripheral_Nerve	Perineurium	A layer of connective tissue surrounding bundles of nerve fibers. It is formed by flattened cells that have a basement membrane on each side.
C33303	Perinuclear_Cisternal_Space	Cell_Part	Perinuclear Cisternal Space
C33304	Periodontium	Tooth_Tissue	Periodontium|Periodontal Ligament|Periodontal Membrane	The fibrous connective tissue surrounding the root of a tooth that separates it from and attaches it to the alveolar bone.
C33305	Periosteal_Cell	Connective_and_Soft_Tissue_Cell	Periosteal Cell	A cell of the loose cellular inner layer of the periosteal tissue in the intramembranous ossification of bone
C33306	Periosteal_Layer_of_the_Dura_Mater	Central_Nervous_System_Part	Periosteal Layer of the Dura Mater
C33308	Peripheral_Zone_of_the_Prostatic_Parenchyma	Prostatic_Tissue	Peripheral Zone of the Prostatic Parenchyma	Prostatic parenchyma that occupies the posterior and lateral aspects of the prostate gland. The glandular architecture consists of small, round acini amid loosely woven, randomly oriented stroma. The peripheral zone contains large, so-called main glands, whose ducts run posteriorly to open into the urethra. Approximately 70% of the prostate gland lies in the peripheral zone.
C33309	Perisinusoidal_Space	Hepatic_Tissue	Perisinusoidal Space|Space of Disse	The area between hepatocytes and the epithelium lining the sinusoids of the liver. The space contains reticular fibers and microvilli from the hepatocytes. Proteins produced by the hepatocytes are transferred to the blood via the perisinusoidal space as blood fluids easily move through the epithelium and microvilli.
C33310	Peritoneal_Mesothelial_Cell	Mesothelial_Cell	Peritoneal Mesothelial Cell
C33311	Periurethral_Zone_of_the_Prostatic_Parenchyma	Prostatic_Tissue	Periurethral Zone of the Prostatic Parenchyma	The inner most portion of the prostatic parenchyma surrounding the mid and proximal portions of the prostatic urethra where the ejaculatory ducts enter the urethra.
C33312	Perivitelline_Space	Female_Reproductive_System_Part	Perivitelline Space
C33313	Permanent_Tooth	Tooth	Permanent Tooth
C33314	Peroneal_Artery	Posterior_Tibial_Artery_Branch	Peroneal Artery
C33315	Phagolysosome	Lysosome	Phagolysosome
C33316	Phagosome	Lysosome	Phagosome
C33317	Phalanx	Long_Bone	Phalanx
C33318	Pharyngeal_Tonsil	Tonsil	Pharyngeal Tonsil|Adenoid
C33319	Photosensitive_Region_of_the_Retina	Eye_Part	Photosensitive Region of the Retina
C33320	Phrenic_Artery	Abdominal_Aorta_Branch	Phrenic Artery
C33321	Pia_Mater	Membrane_of_the_Brain_or_Spinal_Cord	Pia Mater	The delicate, highly vascular, innermost membrane encasing the brain and spinal cord.
C33322	Pillar_Cell	Cell	Pillar Cell	A flattened cell that rests on the tympanic lip of the spiral lamina (inner pillar cell) and on the basilar membrane (outer pillar cell), thereby forming the tunnel of the Organ of Corti.
C33323	Pinealocyte	Neuroepithelial_Cell	Pineocyte|Pinealocyte	A cell of the pineal body with long processes ending in bulbous expansions. Pineocytes receive a direct innervation from sympathetic neurons that form recognizable synapses. The club-shaped endings of pineocyte processes terminate in perivascular spaces surrounding capillaries.
C33324	Pinocytotic_Vesicle	Transport_Vesicle	Pinocytotic Vesicle
C33325	Plantar_Fascia	Fascia	Plantar Fascia
C33326	Plantar_Region	Body_Region	Plantar Region
C33327	Plasma_Membrane_Glycolipid	Cell_Part	Plasma Membrane Glycolipid
C33328	Plasma_Membrane_Lipid_Bilayer	Cell_Part	Plasma Membrane Lipid Bilayer
C33329	Platysma_Myoides	Neck_Muscle	Platysma Myoides
C33330	Pleural_Mesothelial_Cell	Mesothelial_Cell	Pleural Mesothelial Cell
C33331	Pluripotential_Bone_Marrow_Stem_Cell	Bone_Marrow_Stem_Cell_with_Variable_Lineage_Potential|Pluripotent_Stem_Cell	Pluripotent Bone Marrow Stem Cell
C33332	Plus_End_of_the_Actin_Filament	Cell_Part	Plus End of the Actin Filament|Barbed End of Actin Filament|Barbed End of the Actin Filament|Plus End of Actin Filament
C33333	Plus_End_of_the_Microtubule	Cell_Part	Plus End of the Microtubule|Growing End of Microtubule|Growing End of the Microtubule|Plus End of Microtubule
C33334	Podocyte	Epithelial_Cell	Podocyte|Visceral Epithelial Cell	A modified epithelial cell of the capsular epithelium of the renal glomerulus. It has a small perikaryon and a number of primary and secondary foot-like radiating processes (pedicels) that interdigitate with those of other podocytes and embrace the basal lamina of glomerular capillaries.
C33336	Pontine_Branch	Basilar_Artery_Branch	Pontine Branch
C33337	Popliteal_Artery	Artery	Popliteal Artery
C33338	Popliteal_Artery_Branch	Artery	Popliteal Artery Branch
C33339	Popliteal_Vein	Deep_Vein	Popliteal Vein
C33340	Popliteus_Muscle	Muscle	Popliteus Muscle
C33341	Portal_Lobule	Hepatic_Lobule	Portal Lobule	A triangular-shaped unit of hepatic tissue, containing portions of three adjacent hepatic lobules with the portal canal in the center. The portal canal is composed of the portal vein, hepatic artery, bile ductile, and lymph vessel. There is a central vein at the apex of each peripheral corner. Blood flows from the portal vein and hepatic artery towards the central vein. Bile flows in the opposite direction, towards the portal canal.
C33342	Portal_Triad	Hepatic_Tissue	Portal Triad	An anatomical unit of hepatic tissue, composed of an interlobular vein of liver, an interlobular artery of liver and an interlobular bile duct. The triads are embedded in the interlobular connective tissue and travel together throughout the liver parenchyma.
C33343	Portal_Vein	Deep_Vein	Portal Vein
C33344	Portal_Venous_System	Venous_System	Portal Venous System
C33345	Postcapillary_Venule	Venule	Postcapillary Venule
C33346	Postcentral_Gyrus	Cerebral_Gyrus	Postcentral Gyrus
C33347	Postcentral_Sulcus	Cerebral_Sulcus	Postcentral Sulcus
C33348	Posterior_Annular_Ligament	Ligament	Posterior Annular Ligament
C33349	Posterior_Auricular_Vein	Vein_of_the_Head_or_Neck	Posterior Auricular Vein
C33350	Posterior_Carpal_Artery	Ulnar_Artery_Branch	Posterior Carpal Artery
C33351	Posterior_Cerebral_Artery_Branch	Basilar_Artery_Branch	Posterior Cerebral Artery Branch
C33352	Posterior_Choroidal_Artery	Posterior_Cerebral_Artery_Branch	Posterior Choroidal Artery
C33353	Posterior_Circulation_Intracranial_Artery	Intracranial_Artery	Posterior Circulation Intracranial Artery
C33354	Posterior_Circumflex_Artery	Axillary_Artery_Branch	Posterior Circumflex Artery
C33355	Posterior_Column	Spinal_Cord_Column	Posterior Column
C33356	Posterior_Commissure	Brain_Part	Posterior Commissure
C33357	Posterior_Communicating_Artery	Internal_Carotid_Artery_Branch	Posterior Communicating Artery
C33358	Posterior_Cricoarytenoid_Ligament	Laryngeal_Ligament	Posterior Cricoarytenoid Ligament
C33359	Posterior_Cruciate_Ligament	Ligament	Posterior Cruciate Ligament
C33360	Posterior_External_Jugular_Vein	Jugular_Vein	Posterior External Jugular Vein
C33361	Posterior_Fossa	Fossa	Posterior Fossa
C33362	Posterior_Inferior_Cerebellar_Artery	Vertebral_Artery_Branch	Posterior Inferior Cerebellar Artery|PICA
C33363	Posterior_Inferior_Frontal_Convolution	Inferior_Frontal_Convolution	Posterior Inferior Frontal Convolution|Pars Basalis
C33364	Posterior_Infratentorial_Cistern	Infratentorial_Cistern	Posterior Infratentorial Cistern
C33365	Posterior_Longitudinal_Ligament	Ligament	Posterior Longitudinal Ligament
C33366	Posterior_Median_Fissure	Spinal_Cord_Fissure	Posterior Median Fissure of the Spinal Cord
C33367	Posterior_Mediastinal_Artery	Thoracic_Aorta_Branch	Posterior Mediastinal Artery
C33368	Posterior_Mediastinum	Mediastinum_Part	Posterior Mediastinum
C33369	Posterior_Meningeal_Artery	Vertebral_Artery_Branch	Posterior Meningeal Artery
C33370	Posterior_Nucleus_of_the_Thalamus	Brain_Part	Posterior Nucleus of the Thalamus
C33371	Posterior_Olfactory_Lobule	Brain_Part	Posterior Olfactory Lobule|Anterior Perforated Space
C33372	Posterior_Parietal_Artery	Middle_Cerebral_Artery_Branch	Posterior Parietal Artery
C33373	Posterior_Part_of_the_Ambient_Cistern	Lateral_Infratentorial_Cistern	Posterior Part of the Ambient Cistern
C33374	Posterior_Pigment_Epithelium	Epithelium	Posterior Pigment Epithelium	Highly pigmented epithelium covering the posterior surface of the iris.
C33375	Posterior_Pole_of_the_Lens	Eye_Part	Posterior Pole of the Lens
C33376	Posterior_Portion_of_the_Corpus_Callosum_Cistern	Brain_Part	Posterior Portion of the Corpus Callosum Cistern
C33377	Posterior_Quadrigeminal_Body	Quadrigeminal_Body	Posterior Quadrigeminal Body|Inferior Colliculus
C33378	Posterior_Semicircular_Canal	Semicircular_Canal	Posterior Semicircular Canal
C33379	Posterior_Supratentorial_Cistern	Supratentorial_Cistern	Posterior Supratentorial Cistern|Tentorial Notch
C33380	Posterior_Surface_of_the_Liver	Anatomic_Surface|Gastrointestinal_System_Part	Posterior Surface of the Liver
C33382	Posterior_Surface_of_the_Stomach	Anatomic_Surface|Gastrointestinal_System_Part	Posterior Surface of the Stomach
C33383	Posterior_Surface_of_the_Vagina	Anatomic_Surface|Female_Reproductive_System_Part	Posterior Surface of the Vagina
C33384	Posterior_Temporal_Artery	Middle_Cerebral_Artery_Branch	Posterior Temporal Artery
C33385	Posterior_Tibial_Artery_Branch	Artery	Posterior Tibial Artery Branch
C33386	Posterior_Tibial_Vein	Tibial_Vein	Posterior Tibial Vein
C33387	Posterior_Ulnar_Vein	Superficial_Vein	Posterior Ulnar Vein
C33388	Posterior_Wall_of_the_Tympanum	Ear_Part	Posterior Wall of the Tympanum
C33389	Postero-lateral_Fissure	Spinal_Cord_Fissure	Postero-Lateral Fissure of the Spinal Cord
C33390	Postsynaptic_Membrane	Chemical_Synapse_Component	Postsynaptic Membrane
C33391	Pre-B_Lymphocyte	Immature_B-Lymphocyte	Pre-B Lymphocyte
C33392	Precentral_Artery	Middle_Cerebral_Artery_Branch	Precentral Artery
C33393	Precentral_Gyrus	Cerebral_Gyrus	Precentral Gyrus
C33394	Precentral_Sulcus	Cerebral_Sulcus	Precentral Sulcus
C33395	Precentral_Vermian_Vein	Vein	Precentral Vermian Vein
C33396	Premedullary_Cistern	Anterior_Infratentorial_Cistern	Premedullary Cistern
C33397	Prepontine_Cistern	Anterior_Infratentorial_Cistern	Prepontine Cistern
C33398	Presynaptic_Knob	Chemical_Synapse_Component	Presynaptic Knob
C33399	Pre-Thymocyte	Thymocyte	Pre-Thymocyte
C33400	Primordial_Follicle	Ovarian_Follicle	Primordial Follicle
C33401	Primordial_Germ_Cell	Embryonic_Cell|Germ_Cell	Primordial Germ Cell	A mesodermal precursor of germ cells, detectable at four weeks of fetal development. It originates in the allantois and then migrates through the hindgut and into the genital ridge, where it proliferates and differentiates into an oogonia or spermatogonia cell.
C33402	Principal_Sensory_Nucleus_of_the_Trigeminal_Nerve	Brain_Part	Principal Sensory Nucleus of the Trigeminal Nerve
C33403	Procentriole	Centriole	Procentriole
C33404	Processus_Cochleariformis	Ear_Part	Processus Cochleariformis
C33405	Promontory	Ear_Part	Promontory
C33406	Prostate_Capsule	Retired_Concepts	Prostate Capsule
C33407	Prostatic_Duct_Tissue	Prostatic_Tissue	Prostatic Duct Tissue	Simple columnar epithelial tissue of the small canals that transport prostatic secretions from the glandular tubules to the urethra.
C33409	Prostatic_Glandular_Cell	Glandular_Cell	Prostatic Glandular Cell	A secretory cell that produces and secretes prostatic fluid. Prostatic fluid contains citric acid, the enzyme fibrinolysin that liquefies the semen, acid phosphatase, a number of other enzymes and lipids. The secretion of the prostate is the first fraction of the ejaculate.
C33414	Prostatic_Tissue	Tissue	Prostatic Tissue|Prostatic Parenchyma	Tissue composed of tubuloalveolar glands embedded in fibromuscular stroma. The stroma is smooth muscle separated by strands of connective tissue rich in collagenous and elastic fibers. The secretory alveoli of the prostate are irregularly shaped with papillary projections of the mucosa into the lumen of the gland.
C33415	Protoplasmic_Astrocyte	Astrocyte	Protoplasmic Astrocyte
C33416	Proximal_Connecting_Fiber	Cell_Part	Proximal Connecting Fiber
C33417	Proximal_Convoluted_Tube	Kidney_Part	Proximal Convoluted Tube
C33418	Proximal_Part_of_the_Lumen_of_the_Centriole	Cell_Part	Proximal Part of the Lumen of the Centriole
C33419	Pseudostratified_Epithelium	Epithelium	Pseudostratified Epithelium
C33420	Psoas_Major	Psoas_Muscle	Psoas Major|Musculus Psoas Major|Psoas Magnus
C33421	Psoas_Minor	Psoas_Muscle	Psoas Minor|Musculus Psoas Minor|Psoas Parvus
C33422	Psoas_Muscle	Deep_Abdominal_Muscle	Psoas Muscle
C33423	Pubic_Bone	Pelvic_Bone	Pubic Bone
C33424	Pubic_Hair	Hair	Pubic Hair
C33425	Pubic_Symphisis	Joint_of_the_Pelvic_Girdle	Pubic Symphisis
C33426	Pulmonary_Acinus	Respiratory_System_Part	Pulmonary Acinus
C33427	Pulmonary_Artery_Branch	Artery	Pulmonary Artery Branch
C33428	Pulmonary_Lobule	Lung_Tissue	Pulmonary Lobule	The smallest anatomical unit of the lung, measuring 0.50 to 2.00 cm in diameter. Each lobule is composed of 4-8 terminal bronchioles and their distal alveolar ducts and sacs. The lobules are separated by fibrous interlobular septa.
C33429	Pupil	Eye_Part	Pupil
C33430	Purkinje_Fiber	Heart_Part	Purkinje Fiber
C33431	Pyloric_Gland	Exocrine_Gland	Pyloric Gland
C33432	Pyloric_Orifice	Gastrointestinal_System_Part	Pyloric Orifice
C33433	Pyloric_Sphincter	Gastrointestinal_Sphincter	Pyloric Sphincter
C33434	Pyramid	Ear_Part	Pyramid
C33435	Pyramid_of_Ferrein	Renal_Pyramid	Pyramid of Ferrein	Conical structures of the cortical portion of the kidney. The apices of these structures reach the periphery of the kidney, and the bases are applied to the medullary portion.
C33436	Pyramid_of_Malpighi	Renal_Pyramid	Pyramid of Malpighi	Red-colored, striated conical structures of the medullary portion of the kidney. The number of these structures varies from eight to eighteen.
C33437	Pyramidal_Lobe	Thyroid_Gland_Lobe	Pyramidal Lobe|Pyramidal Lobe of the Thyroid
C33438	Pyramidalis	Superficial_Abdominal_Muscle	Pyramidalis|Musculus Pyramidalis
C33439	Pyriform_Sinus	Sinus	Pyriform Sinus
C33440	Quadratus_Lumborum	Deep_Abdominal_Muscle	Quadratus Lumborum
C33441	Quadriceps_Muscle_of_the_Thigh	Muscle	Quadriceps Muscle of the Thigh
C33442	Quadrigeminal_Artery	Posterior_Cerebral_Artery_Branch	Quadrigeminal Artery
C33443	Quadrigeminal_Body	Brain_Part	Quadrigeminal Body
C33444	Quadrigeminal_Cistern	Posterior_Supratentorial_Cistern	Quadrigeminal Cistern
C33445	Radial_Vein_of_the_Upper_Extremity	Superficial_Vein	Radial Vein of the Upper Extremity
C33446	Radix_Dentis	Head_and_Neck_Part	Radix Dentis|Root of Tooth|Root of the Tooth
C33447	Recto-Vaginal_Pouch	Membrane_Part	Recto-Vaginal Pouch|Pouch of Douglass
C33448	Recto-Vesical_Pouch	Membrane_Part	Recto-Vesical Pouch
C33449	Rectus_Abdominis	Superficial_Abdominal_Muscle	Rectus Abdominis
C33450	Recurrent_Artery_of_Heubner	Anterior_Cerebral_Artery_Branch	Recurrent Artery of Heubner
C33451	Red_Fiber	Skeletal_Fiber	Red Fiber
C33452	Refractile_Media	Eye_Part	Refractile Media|Dioptric Media
C33453	Regular_Dense_Connective_Tissue	Dense_Connective_Tissue	Regular Dense Connective Tissue	Connective tissue mainly composed of parallel collagenous fibers leaving little room for embedded fibroblasts. This tissue has high tensile strength, but elasticity and flexibility are limited. Examples are tendons, ligaments and the fasciae and aponeuroses of muscles.
C33454	Renal_Afferent_Vessel	Kidney_Part	Renal Afferent Vessel
C33455	Renal_Cell	Glandular_Cell	Renal Cell	A glandular epithelial cell found in the kidney.
C33456	Renal_Corpuscle	Kidney_Part	Renal Corpuscle
C33457	Renal_Efferent_Vessel	Kidney_Part	Renal Efferent Vessel
C33458	Renal_Interstitial_Cell	Interstitial_Cell	Renal Interstitial Cell	A cell of the interstitial tissue of the renal parenchyma. A renal interstitial cell is one of two types. A type I interstitial cell is a fibroblastic cell that is active in the deposition and degradation of the interstitial matrix. It contributes to fibrosis in response to chronic irritation. A type II cell is a macrophage-derived mononuclear cell with phagocytic and immunologic properties. A type II cell is important in antigen presentation. Its cytokines contribute to recruitment of infiltrating cells, progression of injury, and sustenance of fibrogenesis.
C33459	Renal_Interstitial_Tissue	Connective_and_Soft_Tissue|Renal_Tissue	Renal Interstitial Tissue	Renal tissue consisting of peritubular and periarterial spaces. The relative contribution of each of these two spaces to interstitial volume varies, but increases in size from the cortex to the papilla. In the cortex there is little interstitium because the peritubular capillaries occupy most of the space between the tubules. The cortical interstitial cells and outer medula consist mainly of fibroblastic cells and mononuclear cells. The inner medulla consists primarily of pericytes, lipid-laden cells and mononuclear cells arranged like rungs of a ladder.
C33460	Renal_Papilla	Kidney_Part	Renal Papilla
C33461	Renal_Tissue	Tissue	Renal Tissue	Tissue composed of the renal cortex and the renal medulla. The basic functional unit of renal tissue is the nephron.
C33462	Renal_Vein	Deep_Vein	Renal Vein
C33463	Renshaw_Cell	Interneuron	Renshaw Cell	An inhibitory interneuron in the ventral horn of gray matter of the spinal cord that is held to be reciprocally innervated with a motoneuron so that nerve impulses received by way of processes of the motoneuron stimulate inhibitory impulses back to the motoneuron along an axon of the internuncial cell.
C33464	Reserve_Stem_Cell	Stem_Cell	Reserve Stem Cell
C33465	Respiratory_Bronchiole	Bronchiole	Respiratory Bronchiole
C33466	Rete_Malpighii	Skin_Part	Rete Malpighii|Stratum Germinativum
C33467	Rete_Testis	Male_Reproductive_System_Part	Rete Testis
C33468	Reticular_Fiber	Connective_Tissue_Fiber	Reticular Fiber
C33469	Reticularis_Zone	Endocrine_System_Part	Reticularis Zone
C33470	Retinal_Pigment_Epithelium	Epithelium|Retina	Retinal Pigment Epithelium|RPE	A continuous, insulating monolayer of cuboidal/columnar epithelium which extends from the margins of the optic nerve head to the ora serrata where it is continuous with the pigment epithelium of the pars plana. This cell layer has many physical, optical, metabolic/biochemical and transport functions which play a critical role in the normal visual process, including acting as a selective filter to determine what nutrients reach the retina from the choroid.
C33471	Ridge_of_the_Aqueductus_Fallopii	Ear_Part	Ridge of the Aqueductus Fallopii
C33472	Right_Cerebral_Hemisphere	Cerebral_Hemisphere	Right Cerebral Hemisphere|Right Brain Hemisphere
C33473	Right_Common_Carotid_Artery	Common_Carotid_Artery|Innominate_Artery_Branch	Right Common Carotid Artery
C33474	Right_Common_Iliac_Artery	Common_Iliac_Artery	Right Common Iliac Artery
C33475	Right_Fallopian_Tube	Fallopian_Tube	Right Fallopian Tube
C33476	Right_Hepatic_Duct	Hepatic_Duct	Right Hepatic Duct
C33477	Right_Hypochondriac_Region	Hypochondrial_Region	Right Hypochondriac Region
C33478	Right_Inferior_Frontal_Convolution	Inferior_Frontal_Convolution	Right Inferior Frontal Convolution
C33479	Right_Inguinal_Region	Inguinal_Region	Right Inguinal Region|Right Iliac Region
C33480	Right_Innominate_Vein	Innominate_Vein	Right Innominate Vein
C33481	Right_Lobe_of_the_Liver	Gastrointestinal_System_Part	Right Lobe of the Liver
C33482	Right_Lumbar_Region	Lumbar_Region	Right Lumbar Region
C33483	Right_Lung	Lung	Right Lung
C33484	Right_Lymphatic_Duct	Duct	Right Lymphatic Duct
C33485	Right_Lymphatic_Trunk	Lymphatic_Vessel	Right Lymphatic Trunk
C33486	Right_Main_Bronchus	Main_Bronchus	Right Main Bronchus
C33487	Right_Ovary	Ovary	Right Ovary
C33488	Right_Portion_of_the_Diaphragm	Diaphragm_Part	Right Portion of the Diaphragm
C33489	Right_Pulmonary_Artery	Pulmonary_Artery|Pulmonary_Artery_Branch	Right Pulmonary Artery
C33490	Right_Subclavian_Artery	Innominate_Artery_Branch|Subclavian_Artery	Right Subclavian Artery
C33491	Right_Thyroid_Gland_Lobe	Thyroid_Gland_Lobe	Right Thyroid Gland Lobe
C33493	Rokitansky-Aschoff_Sinus	Diverticulum	Rokitansky-Aschoff Sinus
C33494	Roof_of_the_Fourth_Ventricle	Brain_Part	Roof of the Fourth Ventricle
C33495	Root_of_the_Nail	Integumentary_System_Part	Root of the Nail
C33496	Rostrum_of_the_Corpus_Callosum	Brain_Part	Rostrum of the Corpus Callosum
C33497	Rotator_Cuff	Muscle	Rotator Cuff
C33498	S1_Vertebra	Sacral_Vertebra	S1 Vertebra
C33499	S2_Vertebra	Sacral_Vertebra	S2 Vertebra
C33500	S3_Vertebra	Sacral_Vertebra	S3 Vertebra
C33501	S4_Vertebra	Sacral_Vertebra	S4 Vertebra
C33502	S5_Vertebra	Sacral_Vertebra	S5 Vertebra
C33503	Saccule	Ear_Part	Saccule
C33504	Sacral_Bone	Irregular_Bone	Sacral Bone
C33505	Sacral_Nerve	Spinal_Nerve	Sacral Nerve
C33506	Sacrococcygeal_Joint	Joint_By_Site	Sacrococcygeal Joint
C33507	Sacroiliac_Joint	Joint_By_Site	Sacroiliac Joint
C33508	Sacrum	Body_Region	Sacrum
C33509	Salivary_Gland_Tissue	Tissue	Salivary Gland Tissue	Tissue consisting of mucous or serous secreting epithelial tissue, connective tissue, blood vessels, nerves and lymphatic tissue.
C33510	Salpingopharyngeus	Pharyngeal_Muscle	Salpingopharyngeus
C33511	Saphenous_Vein	Superficial_Vein	Saphenous Vein
C33512	Sarcolemma	Musculoskeletal_System_Part	Sarcolemma
C33513	Sarcoplasm	Musculoskeletal_System_Part	Sarcoplasm
C33514	Sarcoplasmic_Reticulum	Cell_Part	Sarcoplasmic Reticulum
C33515	Sartorius_Muscle	Muscle	Sartorius Muscle
C33516	Satellite_Cell	Connective_and_Soft_Tissue_Cell|Perineural_Cell	Satellite Cell	An elongated cell that is closely associated with a muscle fiber; it either is flattened against the fiber or occupies shallow depressions in its surface.
C33517	Scalene_Muscle	Neck_Muscle	Scalene Muscle
C33518	Sciatic_Artery	Internal_Iliac_Artery_Branch	Sciatic Artery
C33519	Sebaceous_Gland	Exocrine_Gland	Sebaceous Gland
C33520	Sebaceous_Gland_Duct	Duct	Sebaceous Gland Duct
C33521	Sebaceous_Gland_of_the_Eyelash	Sebaceous_Gland	Sebaceous Gland of the Eyelash|Gland of Zeis|Sebaceous Gland of Eyelash
C33522	Second_Portion_of_the_Duodenum	Gastrointestinal_System_Part	Second Portion of the Duodenum|Descending Portion of Duodenum|Descending Portion of the Duodenum|Second Portion of Duodenum
C33523	Secondary_Oocyte	Egg	Secondary Oocyte	A female germ cell in which the first meiotic division is completed. The second meiotic division usually stops short of completion unless fertilization occurs.
C33524	Secretory-stage_Ameloblast	Ameloblast	Secretory-Stage Ameloblast	A cylindrical cell in the innermost layer of the enamel organ which deposits the organic matrix of enamel to create tooth enamel on the surface of the developing tooth.
C33525	Eye_Segment	Eye_Part	Eye Segment|Segment of the Eye
C33526	Segmental_Bronchus	Bronchus	Segmental Bronchus|Tertiary Bronchus
C33527	Semicircular_Canal	Ear_Part	Semicircular Canal
C33528	Semicircular_Duct	Duct|Ear_Part	Semicircular Duct
C33529	Seminal_Fluid	Male_Reproductive_System_Part	Seminal Fluid
C33531	Sensory_Hair	Ear_Part	Sensory Hair
C33532	Sensory_Receptor_of_the_Ear	Ear_Part	Sensory Receptor of the Ear
C33533	Sensory-Somatic_Nervous_System	Peripheral_Nervous_System_Part	Sensory-Somatic Nervous System
C33534	Septal_Cusp	Cardiac_Valve_Cusp	Septal Cusp|Septal Cusp of the Tricuspid Valve
C33535	Septal_Vein	Vein	Septal Vein
C33536	Septum_Pellucidum	Brain_Part	Septum Pellucidum
C33537	Seromucous_Salivary_Gland	Salivary_Gland	Seromucous Salivary Gland
C33538	Serosal_Surface_of_the_Liver	Anatomic_Surface|Serosa	Serosal Surface of the Liver	The membrane lining the external surface of the liver.
C33539	Serous_Salivary_Gland	Salivary_Gland	Serous Salivary Gland
C33540	Serratus_Magnus	Muscle	Serratus Magnus
C33541	Sesamoid_Bone	Short_Bone	Sesamoid Bone
C33542	Sex_Chromosome	Chromosome	Sex Chromosome	The X or Y chromosome in human beings that determines the sex of an individual. Females have two X chromosomes in diploid cells; males have an X and a Y chromosome. The sex chromosomes comprise the 23rd chromosome pair in a human karyotype.
C33543	Shaft_of_the_Hair	Hair_Part	Shaft of the Hair
C33544	Sheath_of_Schwann	Nerve_Sheaths	Sheath of Schwann|Neurilemma	Nerve sheath that is part of the myelinated segment of an axon. It is composed of Schwann cells.
C33545	Short_Bone	Bone	Short Bone
C33546	Short_Saphenous_Vein	Saphenous_Vein	Short Saphenous Vein
C33547	Shoulder_Girdle	Other_Anatomic_Concept	Shoulder Girdle
C33548	Shoulder_Joint	Joint_By_Site	Shoulder Joint
C33549	Sigmoid_Artery	Inferior_Mesenteric_Artery_Branch	Sigmoid Artery
C33550	Sigmoid_Flexure	Gastrointestinal_System_Part	Sigmoid Flexure|Sigmoid Flexure of Colon|Sigmoid Flexure of the Colon
C33551	Sigmoid_Sinus	Retired_Concepts	Sigmoid Sinus
C33552	Simple_Columnar_Epithelium	Columnar_Epithelium|Simple_Epithelium	Simple Columnar Epithelium	Epithelium composed of a single layer of cells that are taller than they are wide. They are found lining the stomach, intestine, uterus and gall bladder. Simple columnar epithelium is efficient at secretion and absorption.
C33553	Simple_Cuboidal_Epithelium	Cuboidal_Epithelium|Simple_Epithelium	Simple Cuboidal Epithelium	Epithelium composed of a single layer of box-shaped cells found lining glands, ducts of glands and kidney tubules. This type of epithelium is efficient at secretion and absorption.
C33554	Simple_Epithelium	Epithelium	Simple Epithelium	Epithelium composed of a single layer of cells attached to a basement membrane.
C33555	Sinoatrial_Node	Heart_Part	Sinoatrial Node|S-A Node
C33556	Sinus	Body_Part	Sinus
C33557	Sinus_of_Valsava	Heart_Part	Sinus of Valsava|Pulmonary Sinus
C33558	Skeletal_Fiber	Musculoskeletal_System_Part	Skeletal Fiber|Skeletal Muscle Fiber
C33561	Skin_of_the_Face	Skin	Skin of the Face
C33562	Skin_Squamous_Cell	Cell_of_the_Epidermis|Squamous_Cell	Skin Squamous Cell	A flat, scale-like epithelial cell found on the outer covering of the body.
C33563	Skin_Tissue	Skin_Part|Tissue	Skin Tissue	Tissue composed of three layers- epidermis, dermis and subcutis which protect underlying muscles and organs. Skin is used for insulation, vitamin D production, sensation, and excretion through sweat.
C33564	Slow-twitch_Motor_Unit	Tissue_Part	Slow-Twitch Motor Unit
C33565	Small_Intestinal_Crypt_of_Lieberkuhn	Crypts_of_the_Lieberkuhn	Small Intestinal Crypt of Lieberkuhn
C33566	Small_Intestinal_Glandular_Cell	Enterocyte	Small Intestinal Glandular Cell	A glandular cell found in the epithelium of the small intestine.
C33567	Small_Intestinal_Goblet_Cell	Goblet_Cell	Small Intestinal Goblet Cell	A unicellular mucous cell found in the epithelium of the small intestine. Droplets of mucigen collect in the upper part of the cell and distend it, while the basal end remains slender, and the cell assumes the shape of a goblet.
C33568	Small_Intestinal_Mucosa	Mucosa|Small_Intestinal_Wall_Tissue	Small Intestinal Mucosa	Mucosa arranged into two fundamental structures - villi and crypts of Lieberkuhn. Villi are projections into the lumen of the small intestine, covered with simple columnar epithelium. Crypts of Lieberkuhn are moat-like invaginations of the epithelium around the villi that extend through the lamina propria down to the muscularis mucosae. Lymphocytes often invade the epithelium or form solitary lymphoid nodules in the lamina propria. Lymph nodules may form longitudinal aggregations of 30-50 nodules in the lamina propria of the ileum. These large aggregations are called Peyer's patches. The muscularis mucosae has two layers and extends into the intestinal villi, where the smooth muscle cells form a longitudinal bundle in the centre of the villi. The small intestinal mucosa secretes gastrin, somatostatin, cholecystokinin and secretin.
C33569	Small_Intestinal_Muscular_Coat	Small_Intestinal_Wall_Tissue	Small Intestinal Muscular Coat	Muscular coat consisting of two layers of smooth muscle - an external, longitudinal, and an internal, circular layer. The longitudinal fibers are thinly scattered over the surface of the small intestine, and are more distinct along its free border. The circular fibers form a thick, uniform layer, and are composed of plain muscle cells of considerable length. The muscular coat is thicker at the upper than at the lower part of the small intestine. Interstitial cells of Cajal are present in the small intestinal muscular coat.
C33570	Small_Intestinal_Muscularis_Mucosa	Muscularis_Mucosa|Small_Intestinal_Mucosa	Small Intestinal Muscularis Mucosa	Two-layered muscularis mucosa extending into the small intestinal villi, where the smooth muscle cells form a longitudinal bundle in the centre of the villi. It is located between the lamina propria and submucosa of the small intestine.
C33571	Small_Intestinal_Serosal_Surface	Anatomic_Surface|Serosa|Small_Intestinal_Wall_Tissue	Small Intestinal Serosal Surface	The thin outermost layer of loose connective tissue covering the outer surface of the small intestine. It is derived from the peritoneum.
C33572	Small_Intestinal_Submucosa	Small_Intestinal_Wall_Tissue|Submucosa	Small Intestinal Submucosa	Loose, filamentous areolar connective tissue between the muscularis mucosa and the muscular coat of the small intestine. It contains blood vessels, lymphatics, and nerves. The duodenal submucosa contains mucus-secreting Brunner's glands.
C33573	Small_Intestinal_Wall_Tissue	Tissue	Small Intestinal Wall Tissue	The tissue of the small intestine. It comprises four layers - mucosa with simple columnar epithelium, submucosa, smooth muscle with inner circular and outer longitudinal layers, and serosa.
C33574	Smegma	Exocrine_Gland_Fluid_or_Secretion	Smegma
C33577	Soluble_Enzymes_of_the_Citric_Acid_Cycle	Cell_Part	Soluble Enzyme of the Citric Acid Cycle|Soluble Enzyme of the Krebs Cycle
C33578	Somatotrope_Cell	Acidophilic_Cell	Somatotroph Cell|GH Cell|Somatotrope Cell|Somatotroph	An acidophil of the adenohypophysis that stains preferentially with orange G and secretes growth hormone.
C33579	Space_of_Fontana	Eye_Part	Space of Fontana
C33580	Space_of_Mall	Gastrointestinal_System_Part	Space of Mall
C33581	Spermatic_Artery	Abdominal_Aorta_Branch	Spermatic Artery
C33582	Spermatogenic_Cell	Germ_Cell	Spermatogenic Cell	A cell that produces sperm.
C33584	Sphenomaxillary_Fossa	Fossa	Sphenomaxillary Fossa
C33585	Sphenoparietal_Sinus	Cardiovascular_System_Part	Sphenoparietal Sinus
C33586	Sphincter_Pupillae_Muscle	Muscle	Sphincter Pupillae Muscle
C33587	Spinal_Artery	Intercostal_Artery_Branch	Spinal Artery
C33588	Spinal_Cord_Column	Spinal_Cord_Part	Spinal Cord Column
C33589	Spinal_Cord_Fissure	Spinal_Cord_Part	Spinal Cord Fissure
C33590	Spinal_Dorsal_Nerve	Spinal_Nerve	Spinal Dorsal Nerve
C33591	Spinal_Vestibular_Nucleus	Vestibular_Nucleus	Spinal Vestibular Nucleus
C33592	Spiral_Artery	Artery	Spiral Artery of the Endometrium|Spiral Artery
C33593	Spiral_Organ_of_Corti	Retired_Concepts	Spiral Organ of Corti
C33594	Spiral_Tube_of_Schchowa	Kidney_Part	Spiral Tube of Schchowa
C33595	Splenial_Artery	Posterior_Cerebral_Artery_Branch	Splenial Artery
C33596	Splenic_Arteriole	Arteriole|Spleen_Part	Splenic Arteriole
C33597	Splenic_Artery	Abdominal_Aorta_Branch	Splenic Artery
C33598	Splenic_Capsule	Organ_Capsule|Spleen_Part	Splenic Capsule
C33599	Splenic_Cord	Spleen_Part	Splenic Cord
C33600	Splenic_Hilar_Lymph_Node	Lymph_Node_by_Anatomic_Site	Splenic Hilar Lymph Node
C33601	Splenic_Hilum	Spleen_Part	Splenic Hilum
C33602	Splenic_Lymphoid_Follicle	Spleen_Part	Splenic Lymphoid Follicle|B-Cell Zone of Spleen|B-Cell Zone of the Spleen
C33603	Splenic_Pulp	Splenic_Tissue	Splenic Pulp	The parenchyma of the spleen, consisting of lymphocytes and macrophages. It lies between the splenic trabecula. Red pulp is the part suffused with blood and white pulp consists of areas of lymphatic tissue where there are sleeves of lymphocytes and macrophages.
C33605	Splenic_Sinus	Sinus|Spleen_Part	Splenic Sinus
C33607	Splenic_Trabecula	Splenic_Tissue	Splenic Trabecula|Splenic Trabeculae	Dense connective tissue structures composed of collagen, elastic, reticular fibers, and smooth muscle cells. They are projections from the splenic capsule into the parenchyma. The arrangement of the fibers permits the spleen to expand passively and to serve as a small temporary reservoir for blood. The trabeculae which originate at the hilus contain and support trabecular arteries and veins which enter and leave the organ at the hilus. Trabeculae from other areas of the capsule do not contain vessels. Arteries branching out of the trabeculae are immediately surrounded by lymphocytes forming the white pulp.
C33608	Splenic_Vein	Vein	Splenic Vein
C33610	Splenium_of_the_Corpus_Callosum	Brain_Part	Splenium of the Corpus Callosum
C33611	Stapedius_Muscle	Muscle_of_the_Tympanum	Stapedius Muscle|Stapedius
C33612	Stapes	Auditory_Ossicle	Stapes
C33613	Stellate_Reticulum	Head_and_Neck_Part	Stellate Reticulum
C33614	Stereocilium	Epithelial_Microvillus	Stereocilium|Stereovillus
C33615	Sternoclavicular_Joint	Joint_By_Site	Sternoclavicular Joint
C33616	Sternocleidomastoid_Muscle	Neck_Muscle	Sternocleidomastoid Muscle|Sternomastoid Muscle
C33617	Sternocostal_Joint	Joint_By_Site	Sternocostal Joint
C33618	Straight_Artery	Artery	Straight Artery of the Endometrium|Straight Artery
C33619	Straight_Sinus	Retired_Concepts	Straight Sinus
C33620	Stratified_Columnar_Epithelium	Columnar_Epithelium|Stratified_Epithelium	Stratified Columnar Epithelium	Epithelium consisting of multiple layers of cells in which the top layer of cells are taller than they are wide. This epithelium is found in salivary gland ducts.
C33621	Stratified_Cuboidal_Epithelium	Cuboidal_Epithelium|Stratified_Epithelium	Stratified Cuboidal Epithelium	Epithelium consisting of multiple layers of cells in which the top layer of cells are box-shaped. It is commonly found in large gland ducts such as sweat gland ducts.
C33622	Stratified_Epithelium	Epithelium	Stratified Epithelium
C33623	Stratum_Basale	Skin_Part	Stratum Basale|Basal Layer
C33624	Stratum_Conjunctum	Skin_Part	Stratum Conjunctum
C33625	Stratum_Corneum	Skin_Part	Stratum Corneum|Horny Layer
C33626	Stratum_Disjunctum	Skin_Part	Stratum Disjunctum
C33627	Stratum_Granulosum	Skin_Part	Stratum Granulosum|Granular Layer
C33628	Stratum_Intermedium	Head_and_Neck_Part	Stratum Intermedium
C33629	Stratum_Lucidum	Skin_Part	Stratum Lucidum|Clear Layer
C33630	Stratum_Papillare	Skin_Part	Stratum Papillare
C33631	Stratum_Reticulare	Skin_Part	Stratum Reticulare
C33632	Striae_Medullares	Brain_Part	Striae Medullares|Auditory Striae
C33634	Striated_Border	Gastrointestinal_System_Part	Striated Border
C33635	Striated_Duct	Duct	Striated Duct
C33637	Striated_Muscle_Tissue_Cell	Muscle_Cell	Striated Muscle Cell|Striated Muscle Tissue Cell|Striated Muscle Tissue Fiber	A cylindrical multinucleated cell containing contracting myofibrils, across which run transverse light and dark areas, enclosed in a delicate plasma membrane.
C33638	Stroma_of_the_Ovarian_Cortex	Female_Reproductive_System_Part	Stroma of the Ovarian Cortex
C33639	Stylopharyngeus	Pharyngeal_Muscle	Stylopharyngeus
C33640	Subarachnoid_Cistern	Central_Nervous_System_Part	Subarachnoid Cistern
C33641	Subcapsular_Epithelium_of_the_Lens	Cuboidal_Epithelium	Subcapsular Epithelium of the Lens	One of the 4 layers of the crystalline lens. It is found between the anterior surface of the capsule and the cortex. It is simple cuboidal epithelium responsible for creating new cells for the lens.
C33642	Lymph_Node_Subcapsular_Sinus	Lymph_Node_Sinus	Lymph Node Subcapsular Sinus|Subcapsular Sinus	The portion of the lymph node between the capsule and cortex. The subcapsular sinus receives lymph from the afferent lymph vessels and passes it to the cortical sinus.
C33643	Subclavian_Artery	Artery	Subclavian Artery
C33644	Subclavius	Muscle	Subclavius
C33645	Subcutis	Skin_Tissue	Subcutis|Subcutaneous Tissue	Adipose tissue located under the dermis. It binds underlying structures with the skin. The subcutis is important in the regulation of temperature of the skin itself and the body. The size of this layer varies throughout the body and from person to person
C33646	Subendocardial_Layer	Heart_Part	Subendocardial Layer
C33647	Subendothelial_Layer	Tissue_Part	Subendothelial Layer
C33648	Subiculum	Brain_Part	Subiculum
C33649	Submandibular_Duct	Duct	Submandibular Duct|Wharton's Duct
C33650	Subscapular_Artery	Axillary_Artery_Branch	Subscapular Artery
C33651	Subscapularis	Rotator_Cuff	Subscapularis
C33652	Substantia_Propria	Eye_Part	Substantia Propria|Sclera Proper|Tenon's Capsule
C33653	Subtalar_Joint	Joint_By_Site	Subtalar Joint
C33654	Sulcus_Centralis	Brain_Part	Sulcus Centralis|Sulcus Centralis Cerebri
C33655	Sulcus_Centralis_Insulae	Cerebral_Sulcus	Sulcus Centralis Insulae
C33656	Sulcus_Limitans	Brain_Part	Sulcus Limitans
C33657	Sulcus_Terminalis	Organ_of_Special_Sense_Part	Sulcus Terminalis
C33658	Superficial_Abdominal_Muscle	Abdominal_Muscle	Superficial Abdominal Muscle
C33659	Superficial_Cervical_Lymph_Node	Cervical_Lymph_Node	Superficial Cervical Lymph Node
C33660	Superficial_Fascia	Fascia	Superficial Fascia
C33661	Superficial_Femoral_Artery	Femoral_Artery_Branch	Superficial Femoral Artery
C33662	Superficial_Intracranial_Venous_System	Intracranial_Venous_System	Superficial Intracranial Venous System
C33663	Superficial_Lymphatic_Vessel	Lymphatic_Vessel	Superficial Lymphatic Vessel
C33664	Superficial_Middle_Cerebral_Vein	Vein	Superficial Middle Cerebral Vein
C33665	Superficial_Palmar_Arch	Ulnar_Artery_Branch	Superficial Palmar Arch
C33666	Superficial_Vein	Systemic_Vein	Superficial Vein
C33667	Superficial_Vein_of_the_Hand	Superficial_Vein	Superficial Vein of the Hand
C33668	Superior_Anastomotic_Vein_of_the_Trolard	Vein	Superior Anastomotic Vein of Trolard
C33669	Superior_Cerebellar_Artery	Basilar_Artery_Branch	Superior Cerebellar Artery|SCA
C33670	Superior_Cerebellar_Cistern	Posterior_Infratentorial_Cistern	Superior Cerebellar Cistern
C33671	Superior_Cerebellopontine_Cistern	Lateral_Infratentorial_Cistern	Superior Cerebellopontine Cistern
C33672	Superior_Constrictor_Muscle	Pharyngeal_Muscle	Superior Constrictor Muscle
C33673	Superior_External_Articular_Artery	Popliteal_Artery_Branch	Superior External Articular Artery
C33674	Superior_Frontal_Convolution	Brain_Part	Superior Frontal Convolution
C33675	Superior_Frontal_Gyrus	Frontal_Gyrus	Superior Frontal Gyrus
C33676	Superior_Frontal_Sulcus	Frontal_Sulcus	Superior Frontal Sulcus
C33677	Superior_Hemorrhoidal_Artery	Inferior_Mesenteric_Artery_Branch	Superior Hemorrhoidal Artery
C33678	Superior_Hypophyseal_Artery	Internal_Carotid_Artery_Branch	Superior Hypophyseal Artery
C33679	Superior_Infratentorial_Cistern	Infratentorial_Cistern	Superior Infratentorial Cistern
C33680	Superior_Intercostal_Vein	Deep_Vein	Superior Intercostal Vein
C33681	Superior_Internal_Articular_Artery	Popliteal_Artery_Branch	Superior Internal Articular Artery
C33682	Superior_Maxillary_Bone	Irregular_Bone	Superior Maxillary Bone
C33683	Superior_Maxillary_Nerve	Peripheral_Nerve	Superior Maxillary Nerve
C33684	Superior_Mediastinum	Mediastinum_Part	Superior Mediastinum
C33685	Superior_Mesenteric_Artery	Abdominal_Aorta_Branch	Superior Mesenteric Artery
C33686	Superior_Mesenteric_Artery_Branch	Artery	Superior Mesenteric Artery Branch
C33687	Superior_Mesenteric_Vein	Vein	Superior Mesenteric Vein
C33688	Superior_Oblique_Muscle	Oculomotor_Muscle	Superior Oblique Muscle
C33689	Superior_Occipital_Convolution	Brain_Part	Superior Occipital Convolution
C33690	Superior_Palpebral_Fold	Head_and_Neck_Part	Superior Palpebral Fold
C33691	Superior_Parathyroid_Gland	Parathyroid_Gland	Superior Parathyroid Gland
C33692	Superior_Parietal_Convolution	Brain_Part	Superior Parietal Convolution
C33693	Superior_Profunda_Artery	Brachial_Artery_Branch	Superior Profunda Artery|Arteria Profunda Brachii
C33694	Superior_Rectus_Muscle	Oculomotor_Muscle	Superior Rectus Muscle
C33695	Superior_Semicircular_Canal	Semicircular_Canal	Superior Semicircular Canal
C33696	Superior_Supratentorial_Cistern	Supratentorial_Cistern	Superior Supratentorial Cistern
C33697	Superior_Surface_of_the_Liver	Anatomic_Surface|Gastrointestinal_System_Part	Superior Surface of the Liver
C33698	Superior_Temporal_Convolution	Brain_Part	Superior Temporal Convolution
C33699	Superior_Temporal_Gyrus	Cerebral_Gyrus	Superior Temporal Gyrus
C33700	Superior_Temporal_Sulcus	Temporal_Sulcus	Superior Temporal Sulcus
C33701	Superior_Thoracic_Artery	Axillary_Artery_Branch	Superior Thoracic Artery
C33702	Superior_Vena_Cava_Opening	Heart_Part	Superior Vena Cava Opening
C33703	Superior_Vestibular_Nucleus	Vestibular_Nucleus	Superior Vestibular Nucleus
C33704	Supporting_Cell_of_the_Nervous_System	Neuron_and_Supporting_Cell_of_the_Nervous_System	Supporting Cell of the Nervous System	A cell that serves to provide support and protection and perhaps contribute to the nutrition of principal or other cells of the nervous system.
C33705	Suprachorioid_Lamina	Membrane	Suprachorioid Lamina|Lamina Fusca	The inner aspect of the sclera, located adjacent to the choroid. It contains thin collagen fibers and elastic fibers, fibroblasts, melanocytes, macrophages, and other connective tissue cells.
C33706	Supramarginal_Gyrus	Cerebral_Gyrus	Supramarginal Gyrus
C33707	Supra-orbital_Vein	Vein_of_the_Head_or_Neck	Supraorbital Vein|Supra-Orbital Vein
C33708	Suprarenal_Artery	Abdominal_Aorta_Branch	Suprarenal Artery
C33709	Supraspinatus	Rotator_Cuff	Supraspinatus
C33710	Supratentorial_Cistern	Subarachnoid_Cistern	Supratentorial Cistern
C33712	Sweat_Gland	Exocrine_Gland	Sweat Gland
C33713	Sweat_Gland_Duct	Duct	Sweat Gland Duct
C33714	Sylvian_Cistern	Anterior_Supratentorial_Cistern	Sylvian Cistern
C33715	Synaptic_Cleft	Chemical_Synapse_Component	Synaptic Cleft
C33716	Synarthrosis	Joint	Synarthrosis
C33717	Synovial_Bursa	Musculoskeletal_System_Part	Synovial Bursa
C33718	Synovial_Fluid	Body_Fluid_or_Substance	Synovial Fluid|Synovia
C33719	Systemic_Vein	Vein	Systemic Vein
C33720	T1_Vertebra	Thoracic_Vertebra	T1 Vertebra
C33721	T10_Vertebra	Thoracic_Vertebra	T10 Vertebra
C33722	T11_Vertebra	Thoracic_Vertebra	T11 Vertebra
C33723	T12_Vertebra	Thoracic_Vertebra	T12 Vertebra
C33724	T2_Vertebra	Thoracic_Vertebra	T2 Vertebra
C33725	T3_Vertebra	Thoracic_Vertebra	T3 Vertebra
C33726	T4_Vertebra	Thoracic_Vertebra	T4 Vertebra
C33727	T5_Vertebra	Thoracic_Vertebra	T5 Vertebra
C33728	T6_Vertebra	Thoracic_Vertebra	T6 Vertebra
C33729	T7_Vertebra	Thoracic_Vertebra	T7 Vertebra
C33730	T8_Vertebra	Thoracic_Vertebra	T8 Vertebra
C33731	T9_Vertebra	Thoracic_Vertebra	T9 Vertebra
C33732	Tail_of_the_Epididymis	Male_Reproductive_System_Part	Tail of the Epididymis
C33733	Tail_of_the_Spermatozoon	Male_Reproductive_System_Part	Tail of the Spermatozoon
C33734	Tarsal_Artery	Dorsalis_Pedis_Artery_Branch	Tarsal Artery
C33735	Tarsal_Joint	Joint_By_Site	Tarsal Joint
C33736	Tarsal_Plate	Head_and_Neck_Part	Tarsal Plate
C33737	Tarsus_Bone	Short_Bone	Tarsus Bone
C33738	Taste_Pore	Epithelium_Part|Organ_of_Special_Sense_Part	Taste Pore
C33739	Tear	Exocrine_Gland_Fluid_or_Secretion	Tear	The stylized shape of a tear or drop of water.  It differs from an oval because one end is clearly larger than the other.  It is synonymous with the shapes egg, pear, and almond.  See also oval.
C33740	Tectorial_Membrane	Membrane	Tectorial Membrane
C33741	Temporal_Artery	External_Carotid_Artery_Branch	Temporal Artery
C33742	Temporal_Fossa	Fossa	Temporal Fossa
C33743	Temporal_Muscle	Muscle_of_the_Mastication	Temporal Muscle
C33744	Temporal_Sulcus	Cerebral_Sulcus	Temporal Sulcus
C33745	Temporary_Tooth	Tooth	Temporary Tooth|Deciduous Tooth
C33746	Temporo-maxillary_Vein	Vein_of_the_Head_or_Neck	Temporo-Maxillary Vein
C33747	Tendinocyte	Connective_and_Soft_Tissue_Cell	Tendinocyte	An elongated cell with invisible cytoplasm and flattened, poorly-stained, nucleus. It is found in the tendon and is positioned in a very regular pattern of rows between parallel bundles of collagen fibers. It makes up the fibers and ground substance of the tendon.
C33748	Tensor_Tympani	Muscle_of_the_Tympanum	Tensor Tympani
C33749	Tentorium_Cerebelli	Central_Nervous_System_Part	Tentorium Cerebelli
C33750	Teres_Major_Muscle	Teres_Muscle	Teres Major Muscle
C33751	Teres_Minor_Muscle	Rotator_Cuff|Teres_Muscle	Teres Minor Muscle
C33752	Teres_Muscle	Muscle	Teres Muscle
C33753	Terminal_Bar	Epithelium_Part	Terminal Bar
C33754	Terminal_Bronchiole	Bronchiole	Terminal Bronchiole
C33755	Terminal_Bronchiole_Epithelium	Simple_Cuboidal_Epithelium	Terminal Bronchiole Epithelium	Epithelium consisting of a single layer of ciliated columnar epithelial cells without goblet cells.
C33756	Terminal_Ductal_Lobular_Unit_Cell	Glandular_Cell	Terminal Ductal Lobular Unit Cell	An epithelial cell found in the small lobes at the end of the milk ducts inside the breast where the milk-producing cells are.
C33757	Terminal_Ileum	Gastrointestinal_System_Part	Terminal Ileum
C33758	Testicular_Tissue	Endocrine_Reproductive_Tissue	Testicular Tissue|Testicular Parenchyma	Parenchyma composed of seminiferous tubules embedded in loose connective interstitial tissue. The interstitial tissue contains clusters of testosterone-secreting Leydig cells, collagen and myoid cells.
C33759	Thalamencephalon	Brain_Part	Thalamencephalon|Inter Brain|Inter-brain
C33760	Thalamostriate_Vein	Vein	Thalamostriate Vein
C33761	Theca_Lutein_Cell	Lutein_Cell	Theca Lutein Cell	A cell of the corpus luteum that is derived from the inner layer of the sheath surrounding the graafian follicle.
C33762	Thick_Filament	Myofilament	Thick Filament
C33763	Thigh	Lower_Extremity_Part	Thigh
C33764	Thin_Filament	Actin_Filament|Myofilament	Thin Filament
C33765	Third_Portion_of_the_Duodenum	Gastrointestinal_System_Part	Third Portion of the Duodenum|Third Portion of Duodenum|Transverse Portion of Duodenum|Transverse Portion of the Duodenum
C33766	Thoracic_Aorta	Aortic_Segment	Thoracic Aorta
C33767	Thoracic_Aorta_Branch	Artery	Thoracic Aorta Branch
C33768	Thoracic_Duct	Duct|Lymphatic_Vessel	Thoracic Duct
C33769	Thoracic_Lymph_Node	Lymph_Node_by_Anatomic_Site	Thoracic Lymph Node
C33770	Thymic_Capsule	Organ_Capsule	Thymic Capsule
C33771	Thymic_Epithelial_Cell	Epithelial_Cell	Thymic Epithelial Cell|TEC	A reticular epithelial cell generated in the thymus that affects T-lymphocyte cell production. Thymic epithelial cells are organized in a three-dimensional network rather than as a sheet of cells on a basement membrane.
C33772	Thymic_Lobule	Thymic_Tissue	Thymic Lobule	A structure in a lobe of the thymus 0.5 -2 mm in diameter. The lobule is divided into an outer cortex and inner medulla. Lobules are separated from each other by connective tissue septa, however, the medullary tissue is continuous from lobule to lobule. Lymphocytes, reticular cells and macrophages are found in the lobules.
C33773	Thymic_Trabecula	Thymic_Tissue	Thymic Trabecula|Thymic Trabeculae
C33774	Thymus_Cortex	Thymic_Tissue	Thymus Cortex
C33775	Thymus_Medulla	Thymic_Tissue	Thymus Medulla
C33776	Thyroarytenoid_Muscle	Laryngeal_Muscle	Thyroarytenoid Muscle
C33777	Thyroepiglottic_Ligament	Laryngeal_Ligament	Thyroepiglottic Ligament
C33778	Thyroepiglottic_Muscle	Laryngeal_Muscle	Thyroepiglottic Muscle|Thyro-epiglottic Muscle
C33779	Thyrohyoid_Ligament	Laryngeal_Ligament	Thyrohyoid Ligament
C33780	Thyroid_Cartilage	Laryngeal_Cartilage	Thyroid Cartilage
C33781	Thyroid_Gland_Capsule	Organ_Capsule	Thyroid Gland Capsule
C33782	Thyroid_Gland_Follicle	Glandular_Epithelial_Tissue|Thyroid_Gland_Epithelial_Tissue	Thyroid Gland Follicle
C33783	Thyroid_Gland_Follicular_Cell	Endocrine_Cell_and_Neuroendocrine_Cell|Glandular_Cell	Thyroid Gland Follicular Cell|Thyroid Follicular Cell	An epithelial cell lining the thyroid follicles.
C33784	Thyroid_Gland_Lobe	Endocrine_System_Part|Head_and_Neck_Part	Thyroid Gland Lobe
C33785	Thyroid_Gland_Tissue	Tissue	Thyroid Gland Tissue
C33786	Thyrotrope_Cell	Acidophilic_Cell	Thyrotroph Cell|Thyrotrope Cell|Thyrotroph
C33787	Tibial_Vein	Deep_Vein	Tibial Vein
C33788	Toe	Digit|Lower_Extremity_Part	Toe
C33789	Toe_Joint	Joint_By_Site	Toe Joint
C33790	Toe_Nail	Nail	Toenail|Toe Nail
C33791	Tonsillar_Crypt	Tonsil_Part	Tonsillar Crypt
C33792	Tonsillohemispheric_Artery	Vertebral_Artery_Branch	Tonsillohemispheric Artery
C33793	Tooth_Cell	Cell	Tooth Cell	The cell of the tooth. It includes the odontoblast, cementoblast, cementocyte, and ameloblast.
C33794	Tooth_Tissue	Tissue	Tooth Tissue
C33795	Torcular_Herophilli	Cardiovascular_System_Part	Torcular Herophilli
C33796	Totipotent_Neuroepithelial_Stem_Cell	Totipotent_Stem_Cell	Totipotent Neuroepithelial Stem Cell	A relatively undifferentiated cell that retains the ability to divide into any type of nerve cell.
C33797	Tracheal_Epithelium	Pseudostratified_Columnar_Ciliated_Epithelium	Tracheal Epithelium	Pseudostratified ciliated columnar epithelium with many Goblet cells, lining the lumen of the trachea. The basement membrane is thick.
C33798	Tract_of_Burdach	Spinal_Cord_Part	Tract of Burdach
C33799	Tract_of_Goll	Spinal_Cord_Part	Tract of Goll
C33800	Tract_of_Lissauer	Spinal_Cord_Part	Tract of Lissauer
C33801	Tragus	Ear_Part	Tragus
C33802	Trans-Golgi_Network	Cell_Part	Trans-Golgi Network|TGN
C33803	Transitional_Zone_of_the_Prostatic_Parenchyma	Prostatic_Tissue	Transitional Zone of the Prostatic Parenchyma
C33804	Transport_Vesicle	Membranous_Cytoplasmic_Organelle	Transport Vesicle
C33805	Transversalis	Muscle	Transversalis
C33806	Transverse_Fissure	Liver_Fissure	Transverse Fissure
C33807	Transverse_Rectal_Fold	Gastrointestinal_System_Part	Transverse Rectal Fold
C33808	Transverse_Sinus	Retired_Concepts	Transverse Sinus
C33809	Trapezius_Muscle	Muscle	Trapezius Muscle
C33810	Triangular_Ligament	Ligament	Triangular Ligament
C33811	Triangular_Part_of_the_Inferior_Frontal_Gyrus	Brain_Part	Triangular Part of the Inferior Frontal Gyrus
C33812	Triceps	Muscle	Triceps|Triceps Muscle
C33813	Trigonum_Olfactorium	Brain_Part	Trigonum Olfactorium
C33814	Trochanter	Musculoskeletal_System_Part	Trochanter
C33815	True_Vocal_Cord	Vocal_Cord	True Vocal Cord
C33816	Trunk	Body_Region	Trunk
C33817	Tuber_Cinereum	Brain_Part	Tuber Cinereum
C33818	Tunica_Adventitia	Blood_Vessel_Tissue	Tunica Adventitia	The outer connective tissue layer of the blood vessel wall. The adventitia consists of longitudinally arranged collagen fibers, elastic fibers, smooth muscle, fibroblasts, nerves and the vasa vasorum. It is thicker in veins than in arteries.
C33819	Tunica_Albuginea	Male_Reproductive_System_Part	Tunica Albuginea
C33820	Tunica_Intima	Blood_Vessel_Tissue	Tunica Intima	The inner most layer of the blood vessel wall. The consistency of the intima will vary depending on the type of blood vessel, but will always have an endothelial layer with a basal lamina. It may contain collagen and elastic fibers.
C33821	Tunica_Media	Vascular_Smooth_Muscle_Tissue	Tunica Media	The middle layer of the blood vessel wall. It consists of concentrically arranged smooth muscle and may include elastic tissue. Its thickness will depend on the type of vessel, thicker in arteries than in veins.
C33822	Tunica_Vaginalis	Male_Reproductive_System_Part	Tunica Vaginalis
C33823	Tunica_Vasculosa	Male_Reproductive_System_Part	Tunica Vasculosa
C33824	Type_I_Epithelial_Receptor_Cell	Taste_Bud_Cell	Type I Epithelial Receptor Cell|Type I Cell	A dark cell found in taste buds. It is rich in free ribosomes, tubular RER and has large dense granules and exhibits AbH immunoreactivity.
C33825	Type_II_Epithelial_Receptor_Cell	Taste_Bud_Cell	Type II Epithelial Receptor Cell|Type II Cell	A light cell found in taste buds that has large amorphous areas of cytoplasmic matrix, scarce ribosomes and RER. Most are alpha-gustducin immunoreactive, some may be AbH immunoreactive and/or PGP 9.5 immunoreactive.
C33826	Ulnar_Artery_Branch	Artery	Ulnar Artery Branch
C33827	Umbilical_Artery	Other_Embryologic_Structure	Umbilical Artery
C33828	Umbilical_Fissure	Liver_Fissure	Umbilical Fissure
C33829	Umbilical_Region	Body_Region	Umbilical Region
C33830	Umbilical_Vein	Other_Embryologic_Structure	Umbilical Vein
C33831	Uncus	Brain_Part	Uncus
C33832	Undersurface_of_the_Frontal_Lobe	Brain_Part	Undersurface of the Frontal Lobe
C33833	Undersurface_of_the_Temporal_Lobe	Brain_Part	Undersurface of the Temporal Lobe
C33834	Unipolar_Neuron	Neuron	Unipolar Neuron	A conducting cell of the nervous system that has only one process extending from the cell body. It is always a sensory neuron.
C33835	Unmyelinated_Nerve_Fiber	Axon	Unmyelinated Nerve Fiber
C33836	Upper_Esophageal_Sphincter	Gastrointestinal_Sphincter	Upper Esophageal Sphincter|UES
C33837	Upper_Gastrointestinal_Tract	Gastrointestinal_System_Part	Upper Gastrointestinal Tract
C33838	Upper_Opening_of_the_Thorax	Opening_of_the_Thorax	Upper Opening of the Thorax
C33839	Upper_Respiratory_System	Respiratory_System_Part	Upper Respiratory System
C33840	Urinary_Space	Kidney_Part	Urinary Space|Bowman's Space
C33841	Urothelial_Cell	Transitional_Cell	Urothelial Cell	A cell found in the layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria.
C33842	Uterine_Gland	Female_Reproductive_System_Part	Uterine Gland
C33843	Utero-Vesical_Pouch	Membrane_Part	Utero-Vesical Pouch
C33844	Utricle	Ear_Part	Utricle
C33845	Utriculosaccular_Duct	Duct	Utriculosaccular Duct
C33847	Vagal_Triangle	Brain_Part	Vagal Triangle
C33848	Vaginal_Fornix	Female_Reproductive_System_Part	Vaginal Fornix
C33849	Cardiac_Valve_Cusp	Heart_Part	Cardiac Valve Cusp
C33850	Valve_of_Kerckring	Gastrointestinal_System_Part	Valve of Kerckring|Circular Fold
C33851	Valve_of_Vieussens	Brain_Part	Valve of Vieussens
C33852	Vasa_Vasorum	Blood_Vessel	Vasa Vasorum
C33853	Vascular_Smooth_Muscle_Tissue	Blood_Vessel_Tissue|Smooth_Muscle_Tissue	Vascular Smooth Muscle Tissue	Smooth muscle tissue found in the tunica media of blood vessels. It controls the diameter of blood vessels. Vascular smooth muscle tissue is autonomous and is in a partial state of contraction at all times.
C33854	Vascular_System	Cardiovascular_System_Part	Vascular System
C33855	Great_Cerebral_Vein_of_Galen	Vein	Great Cerebral Vein of Galen|Vein of Galen
C33856	Vein_of_the_Head_or_Neck	Systemic_Vein	Vein of the Head or Neck
C33857	Velum_Interpositum_Cistern	Posterior_Supratentorial_Cistern	Velum Interpositum Cistern
C33858	Venous_System	Cardiovascular_System_Part	Venous System
C33859	Ventral_Horn_of_the_Spinal_Cord	Spinal_Cord_Part	Ventral Horn of the Spinal Cord
C33860	Ventral_Nerve_Root	Spinal_Cord_Part	Ventral Nerve Root
C33861	Ventroanterior_Nucleus_of_the_Thalamus	Brain_Part	Ventroanterior Nucleus of the Thalamus
C33862	Ventrolateral_Nucleus_of_the_Thalamus	Brain_Part	Ventrolateral Nucleus of the Thalamus
C33863	Ventroposterior_Lateral_Nucleus_of_the_Thalamus	Brain_Part	Ventroposterior Lateral Nucleus of the Thalamus
C33864	Ventroposterior_Medial_Nucleus_of_the_Thalamus	Brain_Part	Ventroposterior Medial Nucleus of the Thalamus
C33865	Vermian_Cistern	Superior_Infratentorial_Cistern	Vermian Cistern
C33866	Vermis	Brain_Part	Vermis|Vermis of Cerebelli
C33867	Vertebral_Artery_Branch	Posterior_Circulation_Intracranial_Artery	Vertebral Artery Branch
C33868	Vertebral_Bone	Irregular_Bone	Vertebral Bone
C33869	Vertebral_Canal	Musculoskeletal_System_Part	Vertebral Canal|Spinal Canal
C33870	Vestibular_Ganglion	Sensory_Ganglion	Vestibular Ganglion|Ganglion of Scarpa
C33871	Vestibular_Labyrinth	Ear_Part	Vestibular Labyrinth
C33873	Vestibule	Ear_Part	Vestibule
C33874	Villus	Gastrointestinal_System_Part	Villus
C33875	Vimentin-like_Filament	Intermediate_Filament	Vimentin-like Filament
C33876	Virchow_s_Cell	Bone_Cell	Virchow's Cell
C33877	Visceral_Afferent_Neuron	Sensory_Neuron	Visceral Afferent Neuron	A cell that conducts a nerve impulse that originated at a receptor in one of the interior organs of the one of the three cavities of the body and proceeds towards the central nervous system.
C33878	Visceral_Efferent_Neuron	Motor_Neuron	Visceral Efferent Neuron	A cell that conducts a nerve impulse that originated in the central nervous system and proceeds towards one of the interior organs of the one of the three cavities of the body.
C33879	Visceral_Layer_of_Bowman_s_Capsule	Kidney_Part	Visceral Layer of Bowman's Capsule
C33880	Visceral_Part_of_the_Peritoneum	Membrane_Part	Visceral Part of the Peritoneum
C33881	Visceral_Pleura	Pleural_Tissue	Visceral Pleura	The layer investing the lungs and dipping into the fissures between the several lobes.
C33882	Visceral_Striated_Muscle_Tissue	Striated_Muscle_Tissue	Visceral Striated Muscle Tissue	Muscle tissue associated with organs such as tongue, pharynx, diaphragm and upper part of the esophagus. It is identical in structure to skeletal muscle tissue.
C33883	Visceral_Surface_of_the_Liver	Anatomic_Surface|Gastrointestinal_System_Part	Visceral Surface of the Liver
C33884	Vitreous_Body	Eye_Part	Vitreous Body
C33885	Vitreous_Chamber	Chamber_of_the_Eye	Vitreous Chamber
C33886	Vocalis_Muscle	Laryngeal_Muscle	Vocalis Muscle
C33887	Voltage-dependent_Anion_Channel	Cell_Part	Voltage-Dependent Anion Channel|Mitochondrial Porin
C33888	Vomer	Musculoskeletal_System_Part	Vomer
C33889	White_Adipose_Tissue	Adipose_Tissue	White Adipose Tissue	Adipose tissue that collects, stores and releases fat in the form of triglycerides. It functions as a heat insulator, mechanical cushion and as a source of energy. White adipose tissue is composed of adipocytes that secrete leptin and other substances that effect energy homeostasis. Its distribution in the body is dependent on the sex of the individual.
C33890	White_Commissure	Commissure	White Commissure
C33891	White_Fiber	Other_Anatomic_Concept	White Fiber
C33892	White_Matter	Nervous_Tissue	White Matter	The nerve tissue forming the bulk of the deep parts of the brain and the superficial parts of the spinal cord. It is composed of nerve cell processes, i.e. extensions (axons), which connect various grey matter areas of the brain to each other and carry nerve impulses to and from the nerve cell bodies within the central nervous system (neurons). Cerebral and spinal white matter does not contain dendrites. White matter is distinguished in that it is composed of axonal nerve fibers covered by a myelin sheath.
C33893	White_Matter_of_the_Spinal_Cord	Spinal_Cord_Part|White_Matter	White Matter of the Spinal Cord	The superficial nerve tissue of the spinal cord. It is composed of nerve cell processes, i.e. extensions (axons), which connect various grey matter areas of the spinal cord to each other and carry nerve impulses to and from the nerve cell bodies within the central nervous system (neurons). Spinal white matter does not contain dendrites. White matter is distinguished in that it is composed of axonal nerve fibers covered by a myelin sheath.
C33894	Wrist_Joint	Joint_By_Site	Wrist Joint|Radiocarpal Joint
C33895	Xiphoid_Process	Musculoskeletal_System_Part	Xiphoid Process
C33896	Zona_Pellucida	Female_Reproductive_System_Part	Zona Pellucida
C33897	Zygomatic_Arch	Flat_Bone	Zygomatic Arch|Zygoma|Zygomatic Bone
C33898	Zygomatic_Fossa	Fossa	Zygomatic Fossa
C33899	Purdue_Pegboard_Test	Test|Test_Generic	Purdue Pegboard Test	The Purdue Pegboard test measures finger dexterity and hand-eye coordination by testing an individual's ability to move hands, fingers, and arms (gross motor movement) and to control movements of small objects (fingertip dexterity).  Measurements of the right hand, left hand, and both hands are part of the test.
C33900	Graviola	Vascular_Plant	Graviola|Annona macrocarpa|Annona muricata|Brazilian Cherimoya|Brazilian Paw Paw|Guanabana	A common name for the tropical tree Annona muricata whose tissues contain annonaceous acetogenins, compounds with antineoplastic activity.  Annonaceous acetogenins, derivatives of long-chain fatty acids, exhibit their anti-tumor properties by depleting cellular stores of adenosine 5'-triphosphate (ATP), a primary source of energy in cells.  These agents also inhibit ATP-driven drug resistance mechanisms.  Possessing a broad range of therapeutic activities, graviola has been used in different cultures for its pesticidal, antifungal,, antispasmodic, anticonvulsant, vasodilator, smooth-muscle relaxant, and hypotensive properties.  (NCI04)
C33901	Agent_Orange	Herbicide	Agent Orange|2,4,D/2,4,5,T	Code name for a synthetic defoliant developed for military use.  Agent Orange is a mixture of two chemicals, 2,4, dichlorophenoxyacetic acid (2,4-D) and 2,4,5 trichlorophenoxyacetic acid (2,4,5-T).  The toxicity of Agent Orange is due to by-products from metabolic processes upon intake. The toxic by products are dioxin derivatives, which have been linked to the wasting syndrome, gastric ulcer, cancer, immunotoxicity, hepatotoxicity, vascular lesions, teratogenicity, and impaired reproductive performance. (NCI04)
C33903	Mouse_Ovarian_Serous_Adenocarcinoma	Mouse_Malignant_Ovarian_Neoplasm	Mouse Ovarian Serous Adenocarcinoma
C33904	Other_Anatomic_Concept	Anatomic_Structure_System_or_Substance	Other Anatomic Concept|Other Anatomy Concept
C33907	Membrane_Associated_Protein-17kDa	Transmembrane_Protein	Membrane Associated Protein 17 kDa|DD96 Protein|Epithelial Protein Up-Regulated In Carcinoma, Membrane Associated Protein 17|MAP17	Mostly expressed in kidney proximal tubular epithelial cells by human MAP17 Gene, 114-aa Membrane Associated Protein 17 kDa is an intracellular protein associated with the cytoplasmic aspect of the apical brush border plasma membrane that interacts with PDZK1. (NCI)
C33908	Minichromosome_Maintenance_Protein-10	MCM_Protein	Minichromosome Maintenance Protein 10|MCM10 Homolog	Encoded by human MCM10 Gene, 98-kD Minichromosome Maintenance Protein 10 binds chromatin during S phase, dissociates in G(2), and is involved in eukaryotic genome replication initiation. MCM10 is regulated by proteolysis and phosphorylation in a cell cycle-dependent manner. MCM10 interacts with ORC2 and with MCM2 and MCM6 of the hexameric MCM2-7 protein complex, a key component of the pre-replication complex and likely involved in formation of replication forks and in recruitment of replication factors. Involved in S phase progression, MCM10 may release MCM2-7 from the origin of replication triggering DNA replication. MCM10 likely binds chromatin after pre-RC assembly and before origin unwinding. (NCI)
C33909	DNA_Replication_Licensing_Factor-MCM4	MCM_Protein	DNA Replication Licensing Factor MCM4|CDC21|CDC21 Homolog|CDC54|Cell Devision Cycle 21 Homolog|MCM4|MCM4 Minichromosome Maintenance Protein 4|P1-CDC21|hCDC21	Encoded by human MCM4 Gene (MCM Family), 863-aa 97-kDa DNA Replication Licensing Factor MCM4 is a highly conserved protein that binds to origin recognition complexes, is essential for replication initiation, and prevents over-replication. A stable complex of MCM4, MCM6, and MCM7 associates with MCM2 specifically bound to histone H3. A key component of the pre-replication complex, hexameric MCM2-7 complex is likely involved in formation of replication forks and recruitment of replication factors. MCM2/4/6/7 complex possesses ATP-dependent DNA helicase activity and may initiate replication as a DNA unwinding enzyme. MCM4 phosphorylation by Cyclin/CDK1,2 suppresses helicase activity and chromatin binding, regulating replication. MCM4 is highly phosphorylated in mitotic cells. (NCI)
C33910	DNA_Replication_Licensing_Factor-MCM5	MCM_Protein	DNA Replication Licensing Factor MCM5|CDC46|CDC46 Homolog|MCM5|P1-CDC46	Encoded by E2F growth-regulated human MCM5 Gene (MCM Family), 734-aa 82-kDa nuclear DNA Replication Licensing Factor MCM5 is a chromatin-binding protein that binds to origin recognition complexes, is required for replication initiation, is structurally similar to replication initiation protein CDC46 (S. cerevisiae), and is related to ATP-dependent helicases. Upregulated in the G0 to G1/S transition, MCM5 may participate in cell cycle regulation. A stable dimeric complex of MCM5/MCM3 associates with replication-specific DNA polymerase alpha-primase complex. MCM3 is acetylated by MCM3AP. MCM proteins also associate with RNA Pol II holoenzyme as components of the transcriptional apparatus. MCM5 interacts directly with the TAD of STAT1, enhancing transcription activation. (NCI)
C33911	DNA_Replication_Licensing_Factor-MCM6	MCM_Protein	DNA Replication Licensing Factor MCM6|MCM6|MIS5|Minichromosome Maintenance Protein 6|P105MCM	Widely expressed by E2F-regulated human MCM6 Gene (MCM Family), 821-aa 93-kDa DNA Replication Licensing Factor MCM6 is a highly conserved MCM protein essential for replication initiation and related to ATP-dependent helicases that binds to origin recognition complex during G1, detaches from it during S phase, and prevents over-replication. Repressed in quiescent cells, MCM6 is rapidly induced at G1/S by growth factor stimulation; protein level peaks at G1/S. A stable MCM2/4/6/7 complex exhibits DNA unwinding ATPase/DNA helicase activity involved in replication initiation. MCM2/4/6/7 phosphorylation by CDC2 kinase reduces helicase activity. Hexameric MCM2-7 complex is a key element of the pre-replication complex and may be involved in formation of replication forks and in recruitment of replication factors. (NCI)
C33912	DNA_Replication_Licensing_Factor-MCM7	MCM_Protein	DNA Replication Licensing Factor MCM7|CDC47|CDC47 Homolog|Minichromosome Maintenance Protein 7|P1.1-MCM3|P1CDC47|PNAS-146|p85MCM	Encoded by human MCM7 Gene (MCM Family), 719-aa 81-kDa DNA Replication Licensing Factor MCM7 is a highly conserved MCM protein essential for replication initiation and related to ATP-dependent helicases that binds to origin recognition complexes and prevents over-replication. A stable MCM2/4/6/7 complex possesses DNA helicase activity and may act as a DNA unwinding enzyme. CDC45 binds to MCM7 and DNA polymerase alpha p70 subunit in the final sequential step of active initiation complex assembly and recruits DNA polymerase alpha to origins of replication. Nonenzymatic p70 forms a tight complex with the catalytic DNA polymerase alpha p180 subunit. The hexameric MCM2-7 complex is a key component of the pre-replication complex and may be involved in formation of replication forks and in recruitment of replication factors. CDK4 associates with MCM7 and MCM7 binds RB1/RB. (NCI)
C33913	MCT-1_Protein	Protein_with_Unknown_or_Unclassified_Function	MCT-1 Protein|MCT-1|MCTS1|Malignant T Cell Amplified Sequence 1 Protein	Encoded by human MCT-1 Gene, MCT-1 Protein has unknown function. (NCI)
C33914	Endocervical_Columnar_Cell	Columnar_Cell	Endocervical Columnar Cell	A mucus-producing epithelial cell lining the endocervical lumen.
C33915	Ectocervical_Squamous_Cell	Squamous_Cell	Ectocervical Squamous Cell	A flat, scale-like epithelial cell that lines the vaginal portion of cervix.
C33916	Reserve_Cell	Epithelial_Cell	Reserve Cell
C33917	Trophoblastic_Cell	Epithelial_Cell	Trophoblastic Cell	A cell from the outside layer of tissue on the blastocyte, a hollow ball of cells formed in the early development of an embryo. It attaches the blastocyte to the endometrium of the uterus and supplies nourishment to the embryo. The chorion and amnion are derived from these cells.
C33918	Syncytiotrophoblast	Other_Embryologic_Structure	Syncytiotrophoblast
C33919	Cytotrophoblast	Other_Embryologic_Structure	Cytotrophoblast
C33920	Intermediate_Trophoblast	Trophoblastic_Cell	Intermediate Type Trophoblastic Cell|Intermediate Trophoblast	A trophoblast that travels into the junctional zone of the decidua, reacting with maternal tissue leukocytes, mainly NK cells, macrophages and T cells, and invades maternal blood vessels feeding the placenta, softening the walls and replacing the lining with fetal tissue.  This junctional zone extends at the edge of the placenta to the amino-chorionic membranes where the chorionic laeve trophoblast has intimate contact with decidua tissue.  One of the primary functions of this cell is in implantation and in the establishment of the uteroplacental circulation since it extensively invades the spiral arteries at the placental site.
C33921	Endometrial_Stromal_Cell	Stromal_Cell	Endometrial Stromal Cell	A cell of the uterine wall immediately underling the endometrial epithelium. Endometrial stromal cells proliferate and respond to the cyclic variations of estrogen and progesterone. These cells produce growth factors and hormones that mediate the proliferative response of epithelial cells to the steroid hormones estrogen and progesterone. In response to embryo implantation, endometrial stromal cells accumulate lipid and glycogen.
C33922	Mucinous_Bronchial_Cell	Goblet_Cell	Mucinous Bronchial Cell|Mucinous Goblet Cell	A columnar epithelial cell found in the bronchi. It secretes mucus.
C33923	Glandular_Cell	Epithelial_Cell	Glandular Cell	An epithelial cell which may release secretions to a free epithelial surface (exocrine) or to the circulatory system (endocrine).
C33924	Ductal_Epithelial_Cell_Retired	Retired_Concepts	Ductal Epithelial Cell
C33925	Thyroid_Gland_Oxyphil_Cell	Endocrine_Cell_and_Neuroendocrine_Cell|Oxyphil_Cell	Thyroid Gland Oxyphil Cell|Hurthle Cell|Hurthle Cells|Thyroid Gland Oxyphilic Cell	A large, granular eosinophilic cell derived from thyroid follicular epithelium by accumulation of mitochondria
C33926	B-Prolymphocyte	Mature_B-Lymphocyte|Prolymphocyte	B-Prolymphocyte	A developmental form in the B-lymphocyte series, intermediate between the B-lymphoblast and the mature B-cell.
C33927	T-Prolymphocyte	Mature_T-Lymphocyte|Prolymphocyte	T-Prolymphocyte	A medium sized round lymphocyte in the T-lymphocyte series, intermediate between the T-lymphoblast and the mature T-cell.
C33929	Left_Colon	Gastrointestinal_System_Part	Left Colon
C33930	T-Lymphoblast	Immature_T-Lymphocyte|Lymphoblast	Precursor T-Lymphoblast|T-Lymphoblast	An immature T-lymphocyte, that has enlarged following stimulation by an antigen, has the capacity to recognize the stimulating antigen and is undergoing proliferation and differentiation either to eliminate the antigen or to a memory state in order to recognize the future appearance of the antigen.
C33931	B-Lymphoblast	Immature_B-Lymphocyte|Lymphoblast	Precursor B-Lymphoblast|B-Lymphoblast	A morphologically immature B-lymphocyte, once thought to represent an early stage in lymphocyte development but now known to be an activated lymphocyte that has been transformed in response to antigenic stimulation.
C33932	Endoderm_Cell	Embryonic_Cell	Endoderm Cell|Endodermal Cell	An embryonic cell of the inner layer of three germ layers that forms the yolk sac and gives rise to the epithelium of the alimentary and respiratory tracts and the parenchyma of associated glands.
C33933	Yolk_Cell	Embryonic_Cell	Yolk Cell	A cell that splits off from the inner cell mass of the blastocyst and becomes part of the primitive yolk sac, which in non-mammals nourishes the embryo during development.
C33934	Angioblast	Embryonic_Cell	Angioblast	A pluripotent cell that can develop into a vascular endothelial cell.
C33935	Ectoderm_Cell	Embryonic_Cell	Ectoderm Cell|Ectodermal Cell	An embryonic cell of the outer layer of three germ layers. These cells give rise to the epidermis and neural tissue.
C33936	Mesoderm_Cell	Embryonic_Cell	Mesoderm Cell|Mesodermal Cell	An embryonic cell of the middle layer of three germ layers that gives rise to the musculoskeletal, vascular, urogenital systems, and connective tissue.
C33937	Neural_Crest_Cell	Ectoderm_Cell	Neural Crest Cell	An embryonic cell that separates from the neural plate during formation of the neural tube and migrates to give several different lineages of adult cells: the spinal and autonomic ganglia, the glial cells of the peripheral nervous system, and nonneuronal cells, such as chromaffin cells, melanocytes and some haemopoietic cells.
C33940	MED6_Homolog_Protein	Transcription_Regulatory_Protein	Mediator of RNA Polymerase II Transcription Subunit 6 Homolog|ARC33|Activator-Recruited Cofactor 33 kDa Component|MED6 Homolog|NY-REN-28 Antigen|RNA Polymerase II Transcriptional Regulation Mediator	Encoded by human MED6 Gene (MED6 Family), 246-aa 28-kDa nuclear Mediator of RNA Polymerase II Transcription Subunit 6 Homolog is a coactivation component of transcriptional mediator complexes involved in transcriptional activation and repression. Transcription requires intermediary proteins that transduce signals from regulatory activator proteins to the basal transcription machinery at the core promoter. Physically associated with RNA polymerase II and essential for transcriptional activation, MED6 appears required for transcriptional activation of most of the RNA polymerase II-transcribed genes and not to be involved in uninduced or repressed transcription, transcription of constitutively expressed genes, or transcription by RNA polymerases I or III. MED6 is a subunit of the multiprotein ARC/DRIP and CRSP complexes. (NCI)
C33941	MASL1_Protein	Protein_with_Unknown_or_Unclassified_Function	MASL1 Protein|MASL1|MFH-Amplified Sequences With Leucine-Rich Tandem Repeats 1 Protein|Malignant Fibrous Histiocytoma Amplified Sequence 1 Protein	Ubiquitously expressed by human MFHAS1 Gene, 1,052-aa 117-kDa MASL1 Protein contains an ATP/GTP-binding site, 3 leucine zipper regions, and a leucine-rich tandem repeat (often elements of interaction among proteins related to the cell cycle). MASL1 shares 36% sequence homology with IGFALS. (NCI)
C33942	Matrix_Gla_Protein	Protein_with_Unknown_or_Unclassified_Function	Matrix Gla Protein|MGLAP|MGP	Upregulated by vitamin D in bone cells and expressed at high levels in heart, kidney, and lung by human MGP Gene (Osteocalcin/MGP Family), 103-aa 12-kDa (precursor) secreted Matrix Gla Protein is associated with the organic matrix of bone and cartilage and is a putative inhibitor of bone formation. Like all known vertebrate vitamin K-dependent proteins, MGP contains a transmembrane signal peptide, a putative gamma-carboxylase recognition site, and a Gla-containing domain. MGP requires vitamin K-dependent gamma-carboxylation for its function. (NCI)
C33943	ENL_Protein	Transcription_Factor	ENL Protein|ENL|MLLT1|Trithorax Homolog 1	Encoded by human MLLT1 Gene, 559-aa 62-kDa nuclear ENL Protein is similar to MLLT3/AF9 (Human), TFG3/ANC1 (Yeast), and trithorax (Drosophila), contains nuclear targeting sequences, serine- and proline-rich regions, and stretches abundant in basic amino acids, and appears capable of transcriptional transactivation in lymphoid and myeloid cells. The C-terminal 90-aa of MLLT1 are required for activation of transcription. A common acute leukemia chromosomal translocation t(11;19)(q23;p13.3) involves MLL/HRX and MLLT1 that results in a rogue chimeric activator protein containing the MLL N-terminal AT-hook motifs. (NCI)
C33944	AF-4_Protein	Transcription_Factor	AF-4 Protein|AF4|FEL Protein|MLLT2|Proto-Oncogene AF4|Trithorax Homolog 2	Widely expressed by human MLLT2 Gene (AF4 Family), 1210-aa 131-kDa AF-4 Protein is a serine- and proline-rich putative transcription factor with a glutamine-rich carboxyl terminus and high sequence homology with ENL protein. A common acute leukemia chromosomal translocation t(4;11)(q21;q23) involves a fusion of MLLT2 and MLL/HRX that form reciprocal products coding for chimeric rogue proteins. (NCI)
C33945	AF-9_Protein	Transcription_Factor	AF-9 Protein|AF9|MLLT3|Trithorax Homolog 3	Encoded by human MLLT3 Gene, 568-aa 63-kDa AF-9 Protein is a putative transcription factor similar to TFG3/ANC1 (Yeast) and contains similar functional domains as MLLT1 and MLLT2 (Human), including nuclear targeting sequences, serine-rich and proline-rich regions, and stretches abundant in basic amino acids. A common acute leukemia chromosomal translocation t(9;11)(p22;q23) involves a fusion of MLLT3 and MLL/HRX that produces a chimeric rogue activator protein. (NCI)
C33946	AF-6_Protein	Protein_with_Unknown_or_Unclassified_Function	AF-6 Protein|AF6|MLLT4|Trithorax Homolog 4	Expressed in a variety of cell types by human MLLT4 Gene, 1816-aa 206-kDa AF-6 Protein is a possible signal transduction protein controlled by Ras signaling pathways that is strongly similar to afadin (rat) and contains short stretches rich in proline, charged amino acids, serines, or glutamines, 1 dilute domain, 1 FHA domain, 1 PDZ/DHR domain, and 2 RAS-associating domains. Shared with several vertebrate and invertebrate proteins, the MLLT4 GLGF motif may be involved in signal transduction at special cell-cell junctions. MLLT4 binds directly to ZO-1 and occludin. MLLT4 may bind to actin filaments, linking the actin cytoskeleton to the plasma membrane at cell-to-cell adherens junctions. A common acute leukemia chromosomal translocation t(6;11)(q27;q23) involves fusion of MLLT4 and MLL/HRX that results in production of a rogue activator protein. (NCI)
C33947	AF-17_Protein	Transcription_Factor	AF-17 Protein|AF17|MLLT6|Trithorax Homolog 6	Encoded by human MLLT6 Gene, 1093-aa 112-kDa AF-17 Protein has high similarity to AF10 and contains amino acid stretches associated with transcriptional repression or activation: a 3-prime leucine-zipper dimerization motif and a terminal cysteine-rich domain of 3 zinc fingers (2 PHD-type) similar to a domain in Br140 protein. A common acute leukemia chromosomal translocation t(11;17)(q23;q21) involves fusion of MLL/HRX and MLLT6 that produces a rogue activator protein. (NCI)
C33948	Forkhead_Box_Protein-O4_Protein	Transcription_Factor	Forkhead Box Protein O4|AFX|AFX1|FOXO4|Fork Head Domain Transcription Factor AFX1|MLLT7|Trithorax Homolog 7	Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas by human MLLT7 Gene (Forkhead Family), 505-aa 54-kDa Forkhead Box Protein O4 is highly similar to forkhead transcription factor FKHR protein within its single forkhead domain and contains serine- and proline-rich regions like ENL protein. AFX-like proteins appear involved in cell cycle regulation. MLLT7 appears to block cell cycle progression at G1, independent of Rb but dependent on p27(KIP1). MLLT7 transcriptionally activates p27(KIP1). MLLT7 may also play a role in the insulin signaling pathway. Acute leukemia chromosomal translocation t(X;11)(q13;q23) involves MLLT7 fused to MLL/HRX that encodes a chimeric rogue activator protein. (NCI)
C33949	Palmitoylated_Membrane_Protein-1	Signaling_Protein	Palmitoylated Membrane Protein 1|55 kDa Erythrocyte Membrane Protein|EMP55|Erythrocyte Membrane Protein p55|PEMP|Palmitoylated Membrane Protein 1 55kD|p55	Expressed in a variety of tissues (abundantly in erythroid stem cells to differentiated reticulocytes) by human MPP1 Gene (MAGUK Family), 466-aa 52-kDa Palmitoylated Membrane Protein 1 contains 1 PDZ/DHR domain, 1 conserved SH3 domain, 1 guanylate kinase-like domain, and a region that binds to cytoskeletal protein 4.1. Tightly associated with the plasma membrane and extensively palmitoylated, MPP1 interacts with DLG5 and is suspected to play a role in signal transduction. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. (NCI)
C33950	_1q23_3	Chromosome_Band	1q23.3	A chromosome band present on 1q
C33951	Myelin_Protein_Zero-Like-1_Protein	Protein_with_Unknown_or_Unclassified_Function	Myelin Protein Zero-Like 1|MPZL1|PZR|Protein Zero-Related	Widely expressed (highest in heart, placenta, kidney, and pancreas) by human MPZL1 Gene (Ig Superfamily), 269-aa 43-kD hyperphosphorylated cell surface membrane glycoprotein Myelin Protein Zero-Like 1 Protein contains an N-terminal signal sequence, an extracellular Ig-like domain with potential N-linked glycosylation sites, a single membrane-spanning segment, and an intracellular pair of consensus immunoreceptor tyrosine-based inhibitory motifs (ITIMs). Specifically binding through its ITIMs to tyrosine phosphatase PTPN11, a positive transducer of growth factor signal transduction, MPZL1 is dephosphorylated by PTPN11, but not by PTPN6, which has a negative role in hematopoietic cell proliferation. Having 45.8% identity with Myelin Protein Zero, MPZL1 may have a role in cell signaling via c-Src. (NCI)
C33952	Thymic_Tissue	Tissue	Thymic Tissue	Tissue composed of a highly cellular outer cortex, and less cellular inner medulla. Both cortex and medulla contain epithelial cells, interdigitating dendritic cells, macrophages, and lymphocytes.
C33953	Virosome	Liposome	Virosome|Virosomes	Virosomes are reconstituted influenza virus (A/Singapore) envelopes. The membrane of these vesicles consists of a spherical, unilamellar lipid bilayer. Purified influenza envelope glycoproteins (hemagglutinin HA and neuramindase NA) are inserted into the lipid bilayer. Virosomes with a bilayer consisting of neutral phospholipids can be used as an unspecific or a specific drug carrier system, while positively charged vesicles can be used as a transfer system for any genetic materials.
C33955	RAS-Related_Protein-MRAS	RAS_Superfamily_Protein	RAS-Related Protein MRAS|MRAS|Muscle RAS Oncogene Homolog|Muscle and Microspikes RAS Protein|RRAS3|Ras-Related Protein RRas3	Encoded by IL9-induced, but not IL2 or IL4, human MRAS Gene (Ras GTPase Family) in brain and heart only, 208-aa 24-kDa RAS-Related Protein MRAS is a GTP-binding protein implicated in neuronal differentiation and activated by NGF, basic FGF, and guanine nucleotide exchange factor GRP, but not by EGF. Activating the MAP kinase pathway, MRAS may serve as a signal transducer to couple specific trophic factors to the MAPK cascade for cell proliferation through activation of B-Raf. (NCI)
C33956	Mature_T-Cell_Proliferation-1_Protein	Protein_with_Unknown_or_Unclassified_Function	Mature T-Cell Proliferation 1 Protein|MTCP-1 Type A|MTCP-1 Type B1|MTCP1|Mature T-Cell Proliferation-1 Type A|Mature T-Cell Proliferation-1 Type B1|p13 MTCP-1 Protein|p13MTCP1|p8 MTCP-1 Protein|p8MTCP1	Expressed in many tissues by human MTCP1 Gene (TCL1 Family) as short 68-aa 8-kDa Type A (high in skeletal muscle) or long 107-aa 13-kDa Type B1 (low level) isoforms, mitochondrial Mature T-Cell Proliferation 1 Protein likely has a role in mature T cell proliferation. MTCP1 is overexpressed in T-cell leukemia bearing a t(X;14) translocation. (NCI)
C33957	MYB_Binding_Protein-1A	Protein_with_Unknown_or_Unclassified_Function	MYB Binding Protein 1A|MYB Binding Protein (p160) 1A|MYBBP1A|PAP2|p160|p53-Activated Protein-2	Widely expressed as a 4.5-kb transcript by human MYBBP1A Gene, 1328-aa 149-kDa MYB Binding Protein 1A contains a central acidic region, C-terminal basic amino acid repeats, and potential leucine charged domain motifs throughout. MYBBP1A shares approximately 80% amino acid sequence similarity with the mouse and rat Mybbp1a homolog, a ubiquitous nucleolar protein that specifically interacts with leucine zipper motifs in the MYB negative regulatory domain (NRD) to modulate MYB hemopoietic cell proliferation and differentiation activity. Disruption of the MYB NRD leucine zipper motif, increases MYB DNA binding, transactivation, and transformation. (NCI)
C33958	Eyelid_Part	Retired_Concepts	Eyelid Part
C33959	Lacrimal_Apparatus_Part	Retired_Concepts	Lacrimal Apparatus Part
C33960	N33_Protein	Protein_with_Unknown_or_Unclassified_Function	N33 Protein|N33|TUSC3	Expressed in most nonlymphoid tissues including prostate, lung, liver, and colon by human N33 Gene (OST3 Family), 348-aa 40-kDa N33 Protein is a potential integral membrane protein. (NCI)
C33961	Neuroblastoma-Amplified_Protein	Protein_with_Unknown_or_Unclassified_Function	Neuroblastoma-Amplified Protein|NAG	A 1352-aa 153-kDa and a 2371-aa 268-kDa isoform of Neuroblastoma-Amplified Protein are expressed in adult and fetal tissues by human NAG Gene. The 1,352-aa protein contains a C-terminal leucine zipper domain and a ribosomal protein S14 signature domain. In addition, the 2,371-aa protein contains an N-terminal leucine zipper motif, 3 putative transmembrane helices, an endoplasmic reticulum signal sequence, and 2 peroxisomal targeting signals. NAG has 2 clusters of nuclear localization signals, one in the N-terminus of the longer variant and the other in the common C-terminus. NAG shares 83 to 86% identity with orthologous mammalian proteins. The C-terminal leucine zipper and ribosomal S14 motif are not conserved in plant and nematode proteins. (NCI)
C33963	NCK_Adaptor_Protein-2	Adaptor_Signaling_Protein	NCK Adaptor Protein 2|Cytoplasmic Protein NCK2|GRB4|NCK-2|NCKBeta|SH2/SH3 Adaptor Protein NCK-Beta	Encoded by human NCK2 Gene, ubiquitous 380-aa 43-kDa cytoplasmic NCK Adaptor Protein 2, containing 1 SH2 domain and 3 SH3 domains, associates with tyrosine-phosphorylated growth factor receptors or their substrates. NCK2 interacts with PINCH and DOCK1. NCK2 shares 68% amino acid identity with NCK-alpha; most differences occur outside the SH2/SH3 domains. NCK2 associates with PDGF and EGF receptors via p62DOK and inhibits DNA synthesis. NCK2 binds to B ephrin cytoplasmic domains in a phosphotyrosine-dependent manner. NCK2-dependent (SH2 domain) B ephrin signaling increases FAK activity, redistributes paxillin, inhibits focal adhesions, and disassembles F-actin fibers. NCK2 SH3 domains bind proteins implicated in cytoskeletal regulation: CAP/ponsin, ABI1, dynamin, PAK1, HNRNPK, and axin. (NCI)
C33964	DNA-Binding_Transcriptional_Activator-NCYM	Transcription_Factor	DNA-Binding Transcriptional Activator NCYM|DNA-Binding Transcriptional Activator|MYCNOS|NCYM|NCYM Protein|V-Myc Myelocytomatosis Viral Related Oncogene, Neuroblastoma Derived (Avian) Opposite Strand	Expressed in fetal brain, lung, liver, and kidney by human NCYM Gene, 109-aa 12-kDa DNA-Binding Transcriptional Activator NCYM contains a helix-loop-helix motif and a basic region. NCYM appears to function as a DNA-binding protein during normal fetal development and is implicated in the pathogenesis of human tumors. The NCYM transcription unit is located on the opposite strand to NMYC, with extensive overlap between the 5-prime ends of the two units. NMYC and NCYM appear to be coregulated under basal growth conditions and in response to retinoic acid. (NCI)
C33965	N-Myc_Downstream_Regulated_Protein-1	Regulatory_Protein	N-Myc Downstream Regulated Protein 1|CAP43|DRG1|Differentiation-Related Gene 1 Protein|NDR1|NDRG1|NDRG1 Protein|Nickel-Specific Induction Protein CAP43|Protein Regulated By Oxygen-1|RIT42|RTP|Reducing Agents and Tunicamycin-Responsive Protein|Tunicamycin-Responsive Protein	Expressed most prominently in placenta, prostate, kidney, small intestine, and ovary, human NDRG1 Gene (NDRG Family, Alpha/Beta Hydrolase Superfamily) encodes ubiquitous cytoplasmic N-Myc Downstream Regulated Protein 1, also associated with the plasma membrane and nucleus. Downregulated by NMYC and rapidly induced by okadaic acid, a serine/threonine phosphatase inhibitor, increased NDRG1 levels are induced by an elevation of free intracellular calcium ion; cells that border lumenae show highest expression. Involved in stress responses, hormone responses, cell growth, and differentiation, NDRG1 may have a growth inhibitory role. (NCI)
C33966	Central_Nervous_System_Part	Nervous_System_Part	Central Nervous System Part
C33967	Neuralized-Like_Protein	Regulatory_Protein	Neuralized-Like Protein|NEURL|Neuralized Homolog|h-NEU	Expressed in brain by human NEURL Gene, 574-aa 62-kDa Neuralized-like Protein is a homolog of neuralized (neu: Drosophila, C. elegans) that appears to be involved in embryonic neurogenic cell fate determination in the central nervous system. Like neu, NEURL contains 2 NHRs (neuralized homology repeats) and a C-terminal RING finger. (NCI)
C33968	Peripheral_Nervous_System_Part	Nervous_System_Part	Peripheral Nervous System Part
C33969	Spinal_Cord_Part	Central_Nervous_System_Part	Spinal Cord Part
C33971	Homeobox_Protein-NK2_Homolog-H	Homeobox_Protein	Homeobox Protein NK2 Homolog H|Homeobox Protein NKX-2.8|NK-2 Homolog 8|NK-2 Homolog H|NK2 Transcription Factor Related Protein|NKX2-9|NKX2.8|NKX2H	Expressed in fetal liver by human NKX2H Gene (NK2 Homeobox Family), 239-aa 26-kDa Homeobox Protein NK2 Homolog H is a basic protein related to nk-2 (Drosophila) homeobox transcription factor containing a homeobox domain and a conserved peptide of nk-2-related proteins. A likely component of PCF (an AFP developmental regulator), NKX2H binds to the AFP gene promoter-linked coupling element (PCE) and activates transcription. (NCI)
C33972	Homeobox_Protein-NKX3A	Homeobox_Protein	Homeobox Protein NKX3A|Homeobox Protein NKX-3.1|NK Homeobox Family 3 Subunit A Homolog|NK3 Transcription Factor Homolog A|NK3 Transcription Factor Related Protein|NKX3-1|NKX3.1|NKX3A	Expressed in a largely prostate-specific and androgen-regulated manner by human NKX3-1 Gene (NK-3 Homeobox Family), nuclear Homeobox Protein NKX3A is a transcription factor containing 1 homeobox domain that preferentially binds the consensus sequence TAAGT[AG] and may regulate proliferation of glandular epithelium. NKX3A may interact with SRF and can also behave as a transcriptional repressor. (NCI)
C33973	Putative_Transmembrane_Protein-NMA	Protein_with_Unknown_or_Unclassified_Function	Putative Transmembrane Protein NMA|BAMBI|BMP and Activin Membrane-Bound Inhibitor|NMA	Expressed in melanocytes, kidney, placenta, spleen, liver, prostate, and gut by human NMA Gene, 260-aa 29-kDa (precursor) Putative Transmembrane Protein NMA contains a signal sequence and a transmembrane domain. (NCI)
C33974	Cell_Surface	Cell_Structure	Cell Surface	The part of the cell membrane that faces the exterior of the cell.
C33975	Neuromedin-U_Protein	Peptide_Hormone	Neuromedin U|NMU|NMU-25|Neuromedin U-25	Expressed throughout the enteric and central nervous systems by human NMU Gene (NMU Family), 174-aa 20-kDa (precursor) secreted Neuromedin U (25-aa) is a potent neuropeptide ligand of G Protein-Coupled Receptor 66 and Neuromedin U Receptor 2 (a GPCR) that stimulates smooth muscle contractions of the ileum, urinary bladder, and uterus, increases blood pressure, alters ion transport in the gut, controls local blood flow, and regulates adrenocortical function. The precursor contains a signal peptide and 4 paired basic residues, putative proteolytic processing sites, indicating that the precursor may generate 3 peptides, including NMU located near the C terminus. (NCI)
C33976	Notch_Homolog-1_Protein	Cell_Surface_Receptor	Notch Homolog 1|NOTCH1|Neurogenic Locus Notch Homolog Protein 1|Notch1 Preproprotein|TAN1|Translocation-Associated Notch Protein TAN-1|hN1	Expressed in adult/fetal tissues by human NOTCH1 Gene (Notch Family), 2556-aa 273-kDa phosphorylated type 1 transmembrane Notch Homolog 1 contains 36 extracellular EGF domains, 3 Lin/Notch repeats, and multiple intracellular domains, including 5 ANK repeats. Cleaved by a Golgi furin-like convertase, cell surface Notch protein is a disulfide linked N-/C-terminal heterodimeric receptor for membrane-bound Jagged1, Jagged2, Delta1, and Serrate on adjacent cells that activates an conserved intercellular signaling pathway (lateral inhibition) to regulate cell-fate determination, differentiation, proliferation, and apoptotic programs. Activated Notch cleavage by TACE and presenilin dependent gamma-secretase releases the intracellular domain to form a transcription complex with RBP-J kappa to activate enhancer of split genes. NOTCH1 interacts with DTX1 and DTX2 and may regulate thymic lymphocyte maturation. (NCI)
C33977	Neuro-Oncological_Ventral_Antigen-2	RNA_Binding_Protein	Neuro-Oncological Ventral Antigen 2|ANOVA|NOVA2|NOVA3|Neuro-Oncological Ventral Antigen 3	Expressed in brain by human NOVA2 Gene, RNA-binding NOVA2 protein is recognized by the paraneoplastic syndrome antibody anti-Ri. NOVA1 and NOVA2 bind to similar RNA ligands with high affinity and may regulate RNA splicing. The NOVA2 KH3 domain interacts with single-stranded RNA; KH3 bound to stem loop RNA resembles a vise, with UCAC held between an invariant Gly-X-X-Gly motif and a variable loop. Tetranucleotide recognition is supported by an aliphatic alpha-helix/beta-sheet RNA-binding platform that mimics UG by making Watson-Crick-like hydrogen bonds with CA. (NCI)
C33978	Natriuretic_Peptide_Receptor-B	Cell_Surface_Receptor	Natriuretic Peptide Receptor B|ANPB|ANPRB|Atrial Natriuretic Peptide B-Type Receptor|Atrial Natriuretic Peptide Receptor B|Atrionatriuretic Peptide Receptor B|GC-B|GUC2B|Guanylate Cyclase B|NPRB	Expressed in heart and vasculature by human NPR2 Gene (Guanylyl Cyclase Family), type I integral membrane protein Natriuretic Peptide Receptor B is the primary receptor for C-type natriuretic peptides that cause natriuresis, sodium excretion in the urine. NPR2 contains an extracellular ligand-binding domain, a membrane-spanning region, and an intracellular protein kinase homology domain, oligomerizing helical hinge region, and a C-terminal guanylyl cyclase catalytic domain activated upon receptor ligand binding. NPR2 seems to be more effectively stimulated by BNP than by ANP. NPR1 and NPR2 are ANP receptors with guanylate cyclase activity; NPR3 is probably responsible for ANP clearance from the circulation without a role in signal transduction. (NCI)
C33979	NR1_Protein	Oxidoreductase	NADPH Dependent Diflavin Oxidoreductase 1|NADPH-Dependent FMN and FAD Containing Oxidoreductase|NDOR1|NR1	Broadly expressed by human NR1 Gene (FNR Family), 597-aa 67-kDa cytoplasmic NADPH-Dependent FMN and FAD Containing Oxidoreductase is an enzyme homologous to cytochrome P-450 reductase that binds FMN, FAD, and NADPH cofactors, reduces cytochrome c, and metabolizes electron acceptors doxorubicin, menadione, and potassium ferricyanide. NR1 shares 41 to 44% similarity with nitric oxide synthase-2, methionine synthase transferase, and P-450 reductase. It may play a role in metabolic activation of bioreductive anticancer drugs and other chemicals activated by 1-electron reduction. (NCI)
C33980	Nuclear_Receptor_Binding_Protein	Protein_with_Unknown_or_Unclassified_Function	Nuclear Receptor Binding Protein|MADM|Multiple Domain Putative Nuclear Protein|Myeloid Leukemia Factor 1 Adaptor Molecule|NRBP|xMUDPNP	Expressed by human NRBP Gene, ubiquitous 535-aa 60-kDa Nuclear Receptor Binding Protein is a putative adaptor protein containing 2 putative nuclear receptor-binding motifs, a putative binding domain for SH2 domain-containing proteins, a kinase-like domain, a bipartite nuclear localization signal, and 3 PEST sequences. Mouse and rat NRBP homologs exhibit 91% and 89% identity with NRBP. (NCI)
C33981	Neuropilin-1_Protein	Cell_Surface_Receptor	Neuropilin 1|NRP|NRP1|VEGF165R|Vascular Endothelial Cell Growth Factor 165 Receptor	Encoded by human NRP1 Gene (Neuropilin Family), Neuropilin 1 contains 1 MAM, 2 F5/8 type C, and 2 CUB domains. Found in embryonic nervous system, and adult heart, placenta lung, liver, skeletal muscle, kidney, and pancreas, type I membrane-bound 923-aa 103-kDa (precursor) isoform 1, expressed by blood vessels, acts as a receptor in cardiovascular development, angiogenesis, formation of neuronal circuits, and organogenesis. Binding to semaphorin 3A, PLGF-2, VEGF-165, and VEGF-B, Isoform 1 appears to mediate chemorepulsion by semaphorins, to increase VEGF-165 binding to KDR, and to regulate VEGF-induced angiogenesis. Expressed in hepatocytes and kidney distal/proximal tubules, secreted 644-aa isoform 2 may bind semaphorins and induce apoptosis by sequestering VEGF-165; it has an adverse effect on blood vessel integrity. Expression of isoforms 1 and 2 does not seem to overlap. (NCI)
C33982	Netrin-1_Protein	Protein_with_Unknown_or_Unclassified_Function	Netrin 1|NTN1|NTN1L|Netrin 1 Homolog	Widely expressed in adult tissues (highest in heart, small intestine, colon, liver, and prostate) by human NTN1 Gene (Laminin Family), 604-aa 68-kDa (precursor) Netrin 1 contains an N-terminal laminin domain, 3 laminin EGF-like domains, and an NTR domain. NTN1 binds to DCC and is thought to be involved in CNS and peripheral motor axon guidance and cell migration during development. Defects in NTN1 are associated with some neuroblastomas. (NCI)
C33983	Neurotrophic_Tyrosine_Kinase_Receptor_Type-2	Receptor_Tyrosine_Kinase	Neurotrophic Tyrosine Kinase Receptor Type 2|BDNF/NT-3 Growth Factors Receptor|GP145-TRKB|NTRK2|TRKB|TRKB Tyrosine Kinase	Widely expressed (mainly neural tissue) by human NTRK2 Gene (IR Tyr Kinase Family) as alternative isoforms TRKB (822-aa 92-kDa precursor), TRKB-T1 (477-aa), and TRKB-T-SHC (537-aa), Neurotrophic Tyrosine Kinase Receptor Type 2 is a type I membrane receptor for BDNF, NTF3, and NTF4/5, but not NGF, involved in development and/or maintenance of the nervous system that contains 2 LRR repeats and 2 Ig-like C2-type domains. Monomeric (low affinity) and dimeric (high affinity) forms appear to exist in dynamic equilibrium. Known substrates for TRK receptors are SHC, PI-3 kinase, and PLC-gamma-1. NTRK2 undergoes ligand-mediated auto-phosphorylation. (NCI)
C33984	Neurotrophic_Tyrosine_Kinase_Receptor_Type-3	Receptor_Tyrosine_Kinase	Neurotrophic Tyrosine Kinase Receptor Type 3|GP145-TRKC|NT3 Growth Factor Receptor|NTRK3|TRKC|TRKC Tyrosine Kinase	Widely expressed (mainly nervous tissue) by human NTRK3 Gene (IR Tyr Kinase Family) as alternative isoforms A (839-aa 94-kDa precursor), B (612-aa), C (825-aa), and D (830-aa), Neurotrophic Tyrosine Kinase Receptor Type 3 is a type I membrane receptor for NTF3 containing 2 LRR repeats and 2 Ig-like C2-type domains. Monomeric (low affinity) and dimeric (high affinity) forms appear to exist in dynamic equilibrium and the isoforms do not have identical signaling properties. Known substrates for TRK receptors are SHC, PI-3 kinase, and PLC-gamma-1. NTRK3 undergoes ligand-mediated auto-phosphorylation. (NCI)
C33985	Nuclear_Mitotic_Apparatus_Protein-1	Regulatory_Protein	Nuclear Mitotic Apparatus Protein 1|NUMA|NUMA1	Encoded by human NUMA1 Gene, Nuclear Mitotic Apparatus Protein 1 is a structural component of the nucleus containing the largest known protein coiled-coil region, present throughout the interphase nucleus, and localized to the mitotic spindle apparatus. Required for organizing mitotic spindle poles, NUMA1 also appears to have a role in nuclear reassembly in late mitosis. NUMA C-terminal region specifically interacts with nuclear transport factor Importin-beta, which inhibits microtubule aster assembly. Regulating NUMA/Importin-beta interaction, Ran GTPase stimulates assembly of microtubule asters and spindles. (NCI)
C33986	Nucleoporin-214kDa	Nucleoporin|Transport_Protein	Nucleoporin 214kDa|CAIN|CAN|CAN Protein|N214|NUP214|Nuclear Pore Complex Protein NUP214|Nucleoporin NUP214|p250	Expressed in thymus, spleen, bone marrow, kidney, brain, and testis by human NUP214 Gene (FG-Repeat NUP Family), 2090-aa 214-kDa homodimeric Nuclear Pore Complex Protein NUP214, likely glycosylated, contains F-G repeats and is associated with cytoplasmic filaments and the cytoplasmic face of the nuclear pore complex. NUP214 is required for proper cell cycle progression and, as a nuclear pore component, may regulate nucleocytoplasmic transport by serving as a docking site in receptor-mediated nuclear import. NUP214 interacts with DDX19 and NUP88. Involved in some cases of leukemia, chromosomal translocation t(6;9)(p23;q34) results in a DEK-NUP214 fusion gene, while chromosomal translocation t(6;9)(q21;q34.1) involves a NUP214/SET gene fusion. (NCI)
C33987	PEG-Interferon_Alfa-2a	Pegylated_Interferon_Alfa	PEG-Interferon Alfa-2a	A covalent conjugate of recombinant interferon alfa, subtype 2a, and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha-2a protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha-2a, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. (NCI04)
C33988	Megakaryocyte-Associated_Tyrosine_Kinase	Protein_Tyrosine_Kinase	Megakaryocyte-Associated Tyrosine Kinase|CHK|CSK-Homologous Kinase|CSK-Type Protein Tyrosine Kinase|CTK|HYL|HYL Tyrosine Kinase|Hematopoietic Consensus Tyrosine-Lacking Kinase|Hydroxyaryl-Protein Kinase|LSK|Leukocyte Carboxyl-Terminal Src Kinase Related Protein|MATK|Megakaryocyte-Associated Tyrosine-Protein Kinase|Protein Kinase HYL|Tyrosine Kinase MATK|Tyrosine-Protein Kinase CTK	Expressed in various myeloid cells, brain, and lung by human MATK Gene (CSK Family), 507-aa 56-kDa cytoplasmic Megakaryocyte-Associated Tyrosine Kinase is similar to CSK tyrosine kinase. MATK contains an SH2 and SH3 domain, a catalytic domain, and a unique N-terminus; it lacks myristylation signals, a negative regulatory phosphorylation site, and an autophosphorylation site. Able to phosphorylate and inactivate SRC tyrosine kinases, MATK may regulate SRC activity in brain by phosphorylating the C-terminal negative regulatory tyrosine. Likely to play a significant role in signal transduction in hematopoietic cells, MATK may inhibit T-cell proliferation. (NCI)
C33989	Endocervical_Mucosa	Mucosa	Endocervical Mucosa	The mucous lining of the canal of the cervix uteri. It is composed of epithelium, basement membrane, lamina propria mucosae, and lamina muscularis mucosae.
C33990	Ectocervical_Mucosa	Mucosa	Ectocervical Mucosa	The mucous covering of the vaginal portion of the cervix. It is composed of epithelium, basement membrane, lamina propria mucosae, and lamina muscularis mucosae.
C33991	MAP-Kinase_Interacting_Kinase-1	Signaling_Protein	MAP Kinase Interacting Kinase 1|MAP Kinase-Interacting Serine/Threonine Kinase 1|MKNK1	Widely expressed by human MKNK1 Gene (Ser/Thr Kinase Family), alternative 465-aa (51-kDa) and 424-aa MAP Kinase Interacting Kinase 1 isoforms contain a typical Ser/Thr kinase domain, an N-terminal putative NLS, and share homology with MAPKAPK2, MAPKAPK3, and p90(RSK). Strongly interacting with, and phosphorylated/activated (via C-terminal region) by, dephosphorylated p38MAP and ERK kinases, but not JNK/SAPK, MKNK1 is activated by many extracellular mitogenic and stress stimuli. Docking with EIF4G1 and -2 C-terminal regions, MNK1 appears to regulate transcription by phosphorylating EIF4E and increasing affinity for the 7-methylG mRNA cap. MNK1 also interacts with the translational inhibitor p97 C- terminus. p97 may sequester MNK1, blocking eIF4E phosphorylation. (NCI)
C33992	Melan-A_Protein	Protein_with_Unknown_or_Unclassified_Function	Melan-A Protein|Antigen LB39-AA|Antigen SK29-AA|MART-1|MART1|MLANA|Melan-A|Melanoma Antigen Recognized By T-Cells 1	Expressed in melanocytes and retina by human MLANA Gene, 118-aa 13-kDa Pro-rich Melan-A Protein is an antigen recognized by cytolytic T lymphocytes that contains no leader sequence but has a putative transmembrane hydrophobic stretch, that may bind HLA-A2, followed by 3 Arg residues. (NCI)
C33993	ALL1-Related_Protein	Protein_with_Unknown_or_Unclassified_Function	Myeloid/Lymphoid or Mixed-Lineage Leukemia Protein 2|ALL1-Related Protein|ALR|MLL2	Expressed in most adult tissues, including hematopoietic cells, except liver by human MLL2 Gene (TRX Family), alternative 5262-aa (564-Da) and 4957-aa isoforms of Myeloid/Lymphoid or Mixed-Lineage Leukemia Protein 2 are putative nuclear transcription factors of the ASCOM complex likely to play a similar role to ALL1 and TRX, although the target genes have yet to be identified. The 5262-aa isoform contains 5 PHD-type zinc fingers, 1 post-SET domain, 1 RING-type zinc finger, and 1 SET domain; the 4957-aa isoform lacks an N-terminal zinc finger and a PHD finger. MLL2 contains 24 amino acid runs, all but 2 of which are Glu runs; proteins with similar features play roles in transcription, translation, and developmental regulation. (NCI)
C33994	Palmitoylated_Membrane_Protein-2	Signaling_Protein	Palmitoylated Membrane Protein 2|DLG2|Discs Large Homolog 2|MAGUK p55 Subfamily Member 2|MPP2|MPP2 Protein	Encoded by human MPP2 Gene (MAGUK Family), 576-aa 65-kDa Palmitoylated Membrane Protein 2 is suspected to play a role in signal transduction and contains 1 PDZ/DHR domain, a conserved SH3 domain, and 1 guanylate kinase-like domain. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. (NCI)
C33995	Palmitoylated_Membrane_Protein-3	Signaling_Protein	Palmitoylated Membrane Protein 3|DLG3|Discs Large Homolog 3|MAGUK p55 Subfamily Member 3|MPP3|MPP3 Protein	Encoded by human MPP3 Gene (MAGUK Family), 585-aa 66-kDa Palmitoylated Membrane Protein 3 is suspected to play a role in signal transduction and contains 1 PDZ/DHR domain, a conserved SH3 domain, and 1 guanylate kinase-like domain. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. (NCI)
C33996	Nuclear_Receptor_Coactivator-5	Transcription_Coactivator	Nuclear Receptor Coactivator 5|CIA|Coactivator Independent of AF2|NCOA5	Widely expressed by human NCOA5 Gene, 579-aa 66-kDa Nuclear Receptor Coactivator 5 contains an LXXLL motif essential for association with nuclear receptors and acts as a coregulator for ESR1, ESR2, and orphan nuclear receptor NR1D2. NCOA5 interacts with ESR1 and ESR2 independently of the steroid binding AF2 domain that regulates interaction with other coreceptors. NCOA5 exerts both coactivator and corepressor functions. (NCI)
C33997	Nuclear_Receptor_Coactivator-6	Transcription_Coactivator	Nuclear Receptor Coactivator 6|AIB3|ASC2|Activating Signal Cointegrator-2|Amplified in Breast Cancer-3 Protein|Cancer-Amplified Transcriptional Coactivator ASC-2|NCOA6|NRC|Nuclear Receptor Coactivator RAP250|Nuclear Receptor-Activating Protein 250 kDa|PPAR-Interacting Protein|PRIP|Peroxisome Proliferator-Activated Receptor Interacting Protein|RAP250|TRBP|Thyroid Hormone Receptor Binding Protein	Encoded by human NCOA6 Gene, ubiquitous 2063-aa 250-kDa mono-/homodimeric Nuclear Receptor Coactivator 6 is a general and nuclear receptor transcriptional coactivator of the ASCOM complex containing two LXXLL motifs (the first mediates ligand-dependent interaction with receptor AF2 domains). NCOA6 directly binds prostanoid, retinoid, vitamin D3, thyroid hormone, and steroid receptors, to strongly enhance transcription in a ligand-/AF2-dependent manner. NCOA6 also appears to interact with RNPC2, NCOA1, CRSP3, RBM14, histone acetyltransferases EP300 and CREBBP, methyltransferases NCOA6IP and HRMT1L1/PRMT2, and with basal transcription factors GTF2A and TBP. Phosphorylated by PRKDC, NCOA6 may coactivate expression via chromatin remodeling and interaction with histone acetyltransferases. It may be involved in coactivation of the NF-kappa-B pathway. (NCI)
C33999	Neogenin_Homolog-1_Protein	Membrane_Protein	Neogenin Homolog 1|NEO1|NGN	Widely expressed human NEO1 Gene (Ig/DCC Family) encodes alternative 1461-aa 60-kDa (precursor) and 1408-aa isoforms of type I membrane protein Neogenin Homolog 1, containing 6 fibronectin type III domains, 4 Ig-like C2-type domains, and roughly 50% amino acid identity to DCC. A possible cell adhesion molecule in many embryonic and adult tissues, NEO1 may be a regulatory protein in the transition of undifferentiated proliferating cells to the differentiated state; chicken neogenin is induced in neural cells immediately before cell cycle withdrawal and terminal differentiation. (NCI)
C34000	Orphan_Nuclear_Receptor-SHP	Transcription_Repressor_Corepressor	Orphan Nuclear Receptor SHP|NR0B2|Nuclear Receptor Subfamily 0 Group B Member 2|SHP|SHP1|Short Heterodimer Partner	Expressed in small intestine, spleen, liver, heart, adrenal gland, and pancreas, human NR0B2 Gene (NR0 Family) encodes 257-aa 28-kDa Orphan Nuclear Receptor SHP, containing a putative ligand-binding domain and a dimerization domain, but lacking a conventional DNA-binding domain. SHP heterodimerizes with nuclear hormone receptors ESR, RAR, RXR, TR, and NR1I3, specifically inhibiting their ligand-dependent transcriptional activation pathways. SHP may repress nuclear receptor-mediated transactivation via two steps: competition with coactivators and direct transcriptional repression. (NCI)
C34001	Neuronal_Cell_Adhesion_Molecule	Cell_Adhesion_Molecule	Neuronal Cell Adhesion Molecule|Bravo|NRCAM|Ng-CAM-Related|NgCAM-Related Cell Adhesion Molecule|Nr-CAM|hBravo	Widely expressed human NRCAM Gene (L1/Neurofascin/NgCAM Family) encodes alternative isoforms of Neuronal Cell Adhesion Molecule, a cell adhesion ankyrin-binding potential type I membrane protein involved in neuron-neuron adhesion and containing 5 fibronectin type III domains and 6 Ig-like C2-type domains. A likely constituent of a neurofascin/NRCAM/ankyrin G complex, NRCAM may play a role in development of the nervous system. Vertebrate and invertebrate cell adhesion molecules in the nervous system are usually cell surface membrane proteins with multiple N-terminal Ig domains, followed by several fibronectin type III repeats, and either a transmembrane intracellular domain or a C-terminal glycophosphatidylinositol-linked membrane anchor. (NCI)
C34002	Neurotrophin-3_Protein	Neurotrophic_Factor	Neurotrophin 3|HDNF|NGF-2|NT3|NTF3|Nerve Growth Factor 2|Neurotrophic Factor	Expressed in brain and peripheral tissues, human NTF3 Gene (NGF-Beta Family) encodes secreted 257-aa 29-kDa (precursor) Neurotrophin 3, a neurotrophin closely related to NGF and BDNF that seems to control survival and differentiation of neurons and may be involved in maintenance of adult nervous system. The mature NTF3 peptide is identical in all mammals examined including human, pig, rat, and mouse. (NCI)
C34003	Hypochondrial_Region	Body_Region	Hypochondrial Region
C34004	Lumbar_Region	Body_Region	Lumbar Region
C34005	Right_Kidney	Kidney	Right Kidney
C34006	Left_Kidney	Kidney	Left Kidney
C34007	Fossa	Body_Part	Fossa
C34008	Round_Ligament_of_the_Liver	Liver_Ligament|Round_Ligament	Round Ligament of the Liver
C34009	Round_Ligament_of_the_Uterus	Round_Ligament	Round Ligament of the Uterus
C34010	Olfactory_Receptor-1G1	G_Protein-Coupled_Receptor	Olfactory Receptor 1G1|OR17-209|OR1G1|OR1G2|Olfactory Receptor 17-209|Olfactory Receptor Family 1 Subfamily G Member 1	Encoded by human OR1G1 Gene (GPCR1 Family), 313-aa 35-kDa integral membrane protein Olfactory Receptor 1G1 is a putative odorant receptor. (NCI)
C34011	Origin_Recognition_Complex_Subunit-1	Sequence-Specific_DNA_Binding_Protein	Origin Recognition Complex Subunit 1|HSORC1|ORC1|ORC1L|Origin Recognition Complex 1|Origin Recognition Complex Subunit 1 Homolog-Like|Origin Recognition Complex Subunit 1-Like|PARC1|Replication Control Protein 1	Expressed by G1 cyclin-dependent kinase activated human ORC1L Gene (ORC1 Family), 861-aa 97-kDa nuclear Origin Recognition Complex Subunit 1 is the largest of 6 conserved subunits of the ORC complex that binds to the consensus ACS of Origins in an ATP-dependent manner, serves as a platform for assembly of additional initiation factors such as CDC6 and MCM proteins, initiates DNA replication, and is essential for viability. Bound to origins throughout the cell cycle, ORC and associated factors modulate local chromatin structure to facilitate replication initiation. Selectively phosphorylated during mitosis and unlike other ORC subunits, ORC1L levels vary during the cell cycle, regulated by ubiquitin-mediated proteolysis after replication initiation. Also involved in transcriptional silencing, ORC1L may interact with MYST histone acetyltransferase 2. (NCI)
C34012	Radial_Artery_of_the_Upper_Extremity	Radial_Artery	Radial Artery of the Upper Extremity
C34013	Radial_Artery_of_the_Endometrium	Radial_Artery	Radial Artery of the Endometrium
C34014	Origin_Recognition_Complex_Subunit-2	Sequence-Specific_DNA_Binding_Protein	Origin Recognition Complex Subunit 2|ORC2|ORC2L|Origin Recognition Complex Protein 2 Homolog|Origin Recognition Complex Subunit 2-Like|Origin of Replication 2 Homolog-Like	Expression (testes highest) not regulated during cell proliferation, human ORC2L Gene (ORC2 Family) encodes 577-aa 66-kDa nuclear Origin Recognition Complex Subunit 2, one of 6 conserved subunits of the ORC complex that binds to the consensus ACS of Origins in an ATP-dependent manner, serves as a platform for assembly of additional initiation factors such as CDC6 and MCM proteins, initiates DNA replication, and is essential for viability. Bound to origins throughout the cell cycle, ORC and associated factors modulate local chromatin structure to facilitate replication initiation. ORC2L forms a core ORC complex with ORC1L, -3L, -4L, and -5L, interacts with CDC45L and MCM10 (important for replication initiation), and has a role in transcriptional silencing. (NCI)
C34015	Origin_Recognition_Complex_Subunit-3	Sequence-Specific_DNA_Binding_Protein	Origin Recognition Complex Subunit 3|LAT|LATHEO|Latheo Homolog|ORC3|ORC3L|Origin Recognition Complex Subunit 3-Like|Origin Recognition Complex Subunit Latheo	Human ORC3L Gene (ORC3 Family) encodes 711-aa 82-kDa nuclear Origin Recognition Complex Subunit 3, one of 6 conserved subunits of the ORC complex that binds to the consensus ACS of Origins in an ATP-dependent manner, serves as a platform for assembly of additional initiation factors such as CDC6 and MCM proteins, initiates DNA replication, and is essential for viability. Bound to origins throughout the cell cycle, ORC and associated factors modulate local chromatin structure to facilitate replication initiation. Important for G1/S transition and containing HLH motifs, ORC3L forms a core ORC complex with ORC2, -3, -4, and -5. The ORC3 N-terminus interacts with the ORC2 C-terminus. The ORC3 C-terminus region brings ORC4 and ORC5 into the core complex. ORC3L has a role in transcriptional silencing and perhaps in neuronal proliferation and olfactory memory. (NCI)
C34016	Origin_Recognition_Complex_Subunit-4	Sequence-Specific_DNA_Binding_Protein	Origin Recognition Complex Subunit 4|ORC4|ORC4L|ORC4P|Origin Recognition Complex Subunit 4-Like	Human ORC4L Gene (ORC4 Family) encodes 436-aa 50-kDa nuclear Origin Recognition Complex Subunit 4, one of 6 conserved subunits of the ORC complex that binds to the consensus ACS of Origins in an ATP-dependent manner, serves as a platform for assembly of additional initiation factors such as CDC6 and MCM proteins, initiates DNA replication, and is essential for viability. Bound to origins throughout the cell cycle, ORC and associated factors modulate local chromatin structure to facilitate replication initiation. ORC4L has a putative nucleotide triphosphate binding motif, associates with multiple cellular proteins, forms a core ORC complex with ORC2L, -3L, and -5L, and has a role in transcriptional silencing. (NCI)
C34017	Origin_Recognition_Complex_Subunit-5	Sequence-Specific_DNA_Binding_Protein	Origin Recognition Complex Subunit 5|ORC5|ORC5L|ORC5P|ORC5T|Origin Recognition Complex Subunit 5-Like	Abundantly expressed in spleen, ovary, testes, colon mucosa, and prostate, human ORC5L Gene (ORC5 Family) encodes 435-aa 50-kDa nuclear Origin Recognition Complex Subunit 5, one of 6 conserved subunits of the ORC complex that binds to the consensus ACS of Origins in an ATP-dependent manner, serves as a platform for assembly of additional initiation factors such as CDC6 and MCM proteins, initiates DNA replication, and is essential for viability. Bound to origins throughout the cell cycle, ORC and associated factors modulate local chromatin structure to facilitate replication initiation. While ORC5 forms a core ORC complex with ORC2L, -3L, and -4L, the ORC5T isoform interacts with ORC4L, but not ORC2L, and regulates assembly of different ORC subcomplexes. ORC5 has a role in transcriptional silencing. (NCI)
C34018	Origin_Recognition_Complex_Subunit-6	Sequence-Specific_DNA_Binding_Protein	Origin Recognition Complex Subunit 6|ORC6|ORC6L|Origin Recognition Complex Subunit 6 Homolog-Like	Expressed throughout the cell cycle, human ORC6L Gene (ORC6 Family) encodes nuclear 252-aa 28-kDa Origin Recognition Complex Subunit 6, one of 6 conserved subunits of the ORC complex that binds to the consensus ACS of Origins in an ATP-dependent manner, serves as a platform for assembly of additional initiation factors such as CDC6 and MCM proteins, initiates DNA replication, and is essential for viability. Bound to origins throughout the cell cycle, ORC and associated factors modulate local chromatin structure to facilitate replication initiation. While ORC6L and ORC1L loosely associate with the core ORC complex of ORC2L, -3L, -4L and -5L, ORC6 also interacts with other proteins, including a 65-kDa hyperphosphoprotein (G1) dephosphorylated in mitosis. Essential in coordinating chromosome replication/segregation with cytokinesis, ORC6L also has a role in transcriptional silencing. (NCI)
C34019	Oncostatin-M_Specific_Receptor_Beta_Subunit	Cytokine_Receptor	Oncostatin-M Specific Receptor Beta Subunit|OSMR|OSMRB|Oncostatin M Receptor	Encoded by human OSMR Gene, 111-kDa 979-aa Oncostatin-M Specific Receptor Beta Subunit is a subunit, with gp130 (a common subunit of IL6 family receptors), for a heterodimeric OSM receptor complex. OSMR contains characteristic motifs of the hematopoietin receptor family. OSM may bind to the gp130 subunit. (NCI)
C34020	Nuclear_LIM_Interactor-Interacting_Factor-2	Protein_with_Unknown_or_Unclassified_Function	Nuclear LIM Interactor-Interacting Factor 2|CTD|CTDSP2|Carboxy-Terminal Domain RNA Polymerase II Polypeptide A Small Phosphatase 2|NIF2|NLI-Interacting Factor 2|OS4|Protein OS-4|SCP2|Small CTD Phosphatase 2	Ubiquitously expressed (highest in pancreas, lowest in liver) by human OS4 Gene (NIF Family), 283-aa 32-kDa Nuclear LIM Interactor-Interacting Factor 2 is a phosphatase that may interact with LDB1.
C34021	Lung_Lobe	Respiratory_System_Part	Lung Lobe
C34022	Anatomic_Surface	Body_Part	Anatomic Surface
C34023	Posterior_Surface_of_the_Kidney	Anatomic_Surface|Kidney_Part	Posterior Surface of the Kidney
C34024	Phosphatidylinositol-4-Phosphate-5-Kinase_Type-II_Alpha	Kinase	Phosphatidylinositol-4-Phosphate 5-Kinase Type II Alpha|1-Phosphatidylinositol-4-Phosphate 5-Kinase|1-Phosphatidylinositol-4-Phosphate Kinase|Diphosphoinositide Kinase|PIP5K2A|PIP5KII-Alpha|PIPK|PtdIns(4)P-5-Kinase|Type II Phosphatidylinositol-4-Phosphate 5-Kinase 53 K	Expressed ubiquitously (high in brain) by human PIP5K2A Gene (PtdIns(4)P-5-Kinase Family), 406-aa 46-kDa Phosphatidylinositol-4-Phosphate 5-Kinase Type II Alpha is a likely homodimer that catalyzes the phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-biphosphate, the precursor to second messengers of phosphoinositide signal transduction pathways involved in regulation of secretion, cell proliferation, differentiation, and motility. PIP5K2A does not show homology to other kinases, but the protein does exhibit kinase activity. (NCI)
C34025	Phosphatidylinositol-4-Phosphate-5-Kinase_Type-II_Beta	Kinase	Phosphatidylinositol-4-Phosphate 5-Kinase Type II Beta|1-Phosphatidylinositol-4-Phosphate Kinase|Diphosphoinositide Kinase|PIP5KIIB|PIPKII-Beta|PTDINS(4)P-5-Kinase	Abundantly expressed (6.3-kb mRNA) in many tissues, human PIP5K2B Gene (PtdIns(4)P-5-Kinase Family) encodes 416-aa plasma membrane targeted Phosphatidylinositol-4-Phosphate 5-Kinase Type II Beta, a homodimer 78% identical in sequence to PIP5K2A that catalyzes phosphorylation of phosphatidylinositol-4-phosphate on the fifth hydroxyl of the myo-inositol ring to form phosphatidylinositol-4,5-bisphosphate, precursor to second messengers of phosphoinositide signal transduction pathways involved in regulation of secretion, cell proliferation, differentiation, and motility. PIP5K isoforms possess almost no homology to kinase motifs in other phosphatidylinositol, protein, and lipid kinases. Conserved basic residues may form a dual specificity site for phosphatidylinositol 3- and 5-phosphates. PIP5K2B specifically interacts with the juxtamembrane region of TNFR1; PIP5K2B activity is increased by TNF-alpha. (NCI)
C34026	Placental_TGF-Beta	Transforming_Growth_Factor-Beta	Placental TGF-Beta|GDF15|Growth/Differentiation Factor 15|MIC1|Macrophage Inhibitory Cytokine-1|NAG1|NRG1|NSAID-Activated Protein 1|NSAID-Regulated Protein 1|Nonsteroidal Anti-Inflammatory Drug-Activated Protein 1|PDF|PTGF-Beta|PTGFB|Placental Bone Morphogenic Protein|Prostate Differentiation Factor	Expressed in activated, but not resting, macrophages and in placenta, prostate, colon, and kidney by human PLAB Gene (BMP/TGF-Beta Family), 308-aa 34-kDa (precursor) Placental TGF-Beta is processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in a disulfide-linked homodimeric secreted mature protein of 224 amino acids. PLAB regulates tissue differentiation and maintenance and reduces the growth of granulocytes and macrophages. Unlike most TGFB superfamily members, in which the amino acid sequence is completely conserved, PLAB shares only 70% amino acid identity with its rodent counterparts. (NCI)
C34027	Aortic_Segment	Blood_Vessel	Aortic Segment
C34028	Kidney_Part	Urinary_System_Part	Kidney Part
C34029	Mediastinum_Part	Body_Part	Mediastinum Part
C34030	Organ_Capsule	Body_Part	Organ Capsule
C34031	Mouse_Pancreatic_Disorder	Mouse_Digestive_System_Disorder	Mouse Pancreatic Disorder|Pancreatic Disorder
C34032	Immunoblast	Activated_Lymphocyte	Immunoblast	An antigenically stimulated lymphocyte. It is a large cell with well-defined cytoplasm, a large nucleus with prominent nuclear membrane, distinct nucleoli, and clumped chromatin.
C34033	B-Immunoblast	Activated_B-Lymphocyte|Immunoblast	B-Immunoblast	A B-lymphocyte that has been transformed (activated) in response to antigenic stimulation.
C34034	T-Immunoblast	Immunoblast|Mature_T-Lymphocyte	T-Immunoblast	A T-lymphocyte that has been transformed (activated) in response to antigenic stimulation. It will give rise to a population of T cells with specificity against the stimulating antigen.
C34035	Mouse_Pancreatic_Neoplasm	Mouse_Digestive_System_Neoplasms|Mouse_Pancreatic_Disorder	Mouse Pancreatic Neoplasm|Pancreatic Neoplasm
C34036	Mouse_Pancreatic_Acinar_Neoplasm	Mouse_Pancreatic_Neoplasm	Mouse Pancreatic Acinar Neoplasm|Pancreatic Acinar Neoplasm
C34037	Benign_Mouse_Pancreatic_Neoplasm	Mouse_Pancreatic_Neoplasm	Benign Mouse Pancreatic Neoplasm
C34038	Mouse_Acinar_Cell_Adenoma	Benign_Mouse_Pancreatic_Neoplasm	Mouse Acinar Cell Adenoma|Acinar Cell Adenoma
C34039	Mouse_Mixed_Acinar_Islet_Cell_Adenoma	Benign_Mouse_Pancreatic_Neoplasm	Mouse Mixed Acinar/Islet Cell Adenoma|Mixed Acinar/Islet Cell Adenoma	Prominent nucleolus, basophilic cytoplasm of enlarged acinar and islet cells
C34040	Malignant_Mouse_Pancreatic_Neoplasm	Mouse_Pancreatic_Neoplasm	Malignant Mouse Pancreatic Neoplasm|Malignant Pancreatic Neoplasm
C34041	Mouse_Pancreatic_Ductal_Adenocarcinoma	Malignant_Mouse_Pancreatic_Neoplasm	Mouse Pancreatic Ductal Adenocarcinoma|Pancreatic Ductal Adenocarcinoma
C34042	Mouse_Acinar_Cell_Adenocarcinoma	Malignant_Mouse_Pancreatic_Neoplasm	Mouse Acinar Cell Adenocarcinoma|Acinar Cell Adenocarcinoma
C34043	Mouse_Islet_Cell_Carcinoma	Malignant_Mouse_Pancreatic_Neoplasm	Mouse Islet Cell Carcinoma|Islet Cell Carcinoma|Pancreatic Endocrine Carcinoma
C34044	Mouse_Islet_Cell_Adenocarcinoma	Mouse_Islet_Cell_Carcinoma	Mouse Islet Cell Adenocarcinoma|Islet Cell Adenocarcinoma|Pancreatic Endocrine Adenocarcinoma	Severe dysplasia, disruption of normal architecture, increased mitotic activity, loss of cellular polarity
C34045	Mouse_Pancreatic_Intraepithelial_Neoplasia-1	Mouse_Pancreatic_Neoplasm	Mouse Pancreatic Intraepithelial Neoplasia-1|PanIN-1|Pancreatic Intraepithelial Neoplasia-1
C34047	Mouse_Pancreatic_Intraepithelial_Neoplasia-1B	Mouse_Pancreatic_Intraepithelial_Neoplasia-1	Mouse Pancreatic Intraepithelial Neoplasia-1B|Ductal Hyperplasia|PanIN-1B|Papillary Duct Lesion Without Atypia|Papillary Hyperplasia	These epithelial lesions have a papillary, micropapillary or basally pseudostratified architecture, but are otherwise identical to PanIN-1A.
C34048	Mouse_Pancreatic_Intraepithelial_Neoplasia-2	Mouse_Pancreatic_Neoplasm	Mouse Pancreatic Intraepithelial Neoplasia-2|Adenomatoid Hyperplasia|Adenomatous Hyperplasia|Atypical Hyperplasia|Low-Grade Dysplasia|PanIN-2|Pancreatic Intraepithelial Neoplasia-2|Papillary Duct Lesion With Atypia	These mucinous epithelial lesions may be flat or papillary. These lesions must have some nuclear abnormalities including some loss of polarity, nuclear crowding, enlarged nuclei, pseudo-stratification and hyperchromatism. Mitoses are rare, but when present are non-luminal (not apical) and not atypical.
C34049	Mouse_Pancreatic_Intraepithelial_Neoplasia-3	Mouse_Pancreatic_Neoplasm	Mouse Pancreatic Intraepithelial Neoplasia-3|Carcinoma Insitu|High-Grade Dysplasia|Intraductal Carcinoma|PanIN-3|Pancreatic Intraepithelial Neoplasia-3|Severe Dysplasia	These are usually papillary or micropapillary, however, they may rarely be flat. True cribriforming, budding off of small clusters of epithelial cells into the lumen and luminal necroses. There is loss of nuclear polarity, dystrophic goblet cells (goblet cells with nuclei oriented towards the lumen and mucinous cytoplasm oriented toward the basement membrane), mitoses which may occasionally be abnormal, nuclear irregularities and prominent (macro) nucleoli.
C34050	Mouse_Islet_Cell_Neoplasm	Mouse_Pancreatic_Neoplasm	Mouse Islet Cell Neoplasm|Islet Cell Neoplasm|Pancreatic Adenoma|Pancreatic Endocrine Neoplasm
C34051	Mouse_Islet_Cell_Adenoma	Mouse_Islet_Cell_Neoplasm	Mouse Islet Cell Adenoma|Islet Cell Adenoma	Increased size, compression of adjacent tissue. Often form branching tubular structures, enlarged nuclei with prominent nucleolus.
C34052	Mouse_Somatostatinoma	Mouse_Islet_Cell_Neoplasm	Mouse Somatostatinoma|Somatostatin Producing Neoplasm|Somatostatinoma	A rare somatostatin-secreting tumor of pancreatic delta cells associated with diabetes mellitus or abnormal glucose tolerance.
C34053	Mouse_Insulinoma	Mouse_Islet_Cell_Neoplasm	Mouse Insulinoma|Insulin Producing Neoplasm|Insulinoma	This is a rare insulin secreting neuroendocrine tumor.
C34054	Mouse_Glucagonoma	Mouse_Islet_Cell_Neoplasm	Mouse Glucagonoma|Glucagon Producing Neoplasm|Glucagonoma	Glucagon-secreting tumor of the pancreatic alpha cells.
C34055	Extraembryonic_Structure	Embryologic_Structure_or_System	Extraembryonic Structure
C34056	Mouse_Pancreatic_Intraepithelial_Neoplasia-1A	Mouse_Pancreatic_Intraepithelial_Neoplasia-1	Mouse Pancreatic Intraepithelial Neoplasia-1A|Flat Duct Lesion Without Atypia|Flat Ductal Hyperplasia|Goblet Cell Metaplasia|Mucinous Cell Hyperplasia|Mucinous Ductal Hyperplasia|Mucinous Hypertrophy|Non-Papillary Epithelial Hypertrophy|PanIN-1A|Pancreatic Intraepithelial Neoplasia-1A|Pyloric Gland Metaplasia|Simple Hyperplasia	Flat epithelial lesions composed of tall columnar cells with basally located nuclei and abundant supranuclear mucin. The nuclei are small and round to oval in shape. When oval the nuclei are oriented perpendicular to the basement membrane. There is considerable histologic overlap between non-neoplastic flat hyperplastic lesions and flat neoplastic lesions without atypia.
C34057	Gastrula	Embryo	Gastrula
C34058	Trilaminar_Embryonic_Disc	Embryonic_Disc	Trilaminar Embryonic Disc
C34059	Embryonic_Urogenital_System	Other_Embryologic_Structure	Embryonic Urogenital System
C34060	Autonomic_Nervous_System_Part	Peripheral_Nervous_System_Part	Autonomic Nervous System Part
C34061	Reproductive_System_Part	Body_Part	Reproductive System Part
C34062	Exocrine_Gland_Fluid_or_Secretion	Body_Fluid_or_Substance	Exocrine Gland Fluid or Secretion
C34063	Phospholipase-A2_Group-IIA	Phospholipase-A2	Phospholipase A2 Group IIA|GIIC sPLA2|Group IIA Phospholipase A2|Membrane Associated Phospholipase A2|NPS-PLA2|Non-Pancreatic Secretory Phospholipase A2|PLA2B|PLA2G2A|PLA2L|PLA2S|PLAS1|Phosphatidylcholine 2-Acylhydrolase	Expressed in many cells by human PLA2G2A Gene (PLA2 Type II Family), identical membrane-bound and secreted forms of 144-aa 16-kDa (precursor) Phospholipase A2 Group IIA catalyze calcium-dependent hydrolysis of sn-2 fatty acid acyl ester bonds in 3-sn-phosphoglycerides, releasing free fatty acids and lysophospholipids. Thought to regulate biomembrane phospholipid metabolism and eicosanoid biosynthesis, PLA2G2A is likely involved in a variety of cellular processes, including production of precursors for inflammatory reactions. (NCI)
C34064	Pleiomorphic_Adenoma-Like_Protein-1	Transcription_Factor	Pleiomorphic Adenoma-Like Protein 1|PLAG-Like 1|PLAGL1|Pleomorphic Adenoma Gene-Like 1 Protein|ZAC Tumor Supressor|Zinc Finger Protein PLAGL1	Widely expressed by human PLAGL1 Gene (Krueppel Family), 411-aa 45-kDa DNA-binding transcriptional activator Pleomorphic Adenoma-Like Protein 1 contains 7 C2H2-type zinc fingers and inhibits cell proliferation through induction of the p53 apoptosis and cell cycle arrest pathways. PLAGL1 also regulates pituitary adenylate cyclase-activating polypeptide type 1 receptor, a potent insulin secretagogue and mediator of autocrine control of insulin secretion in the pancreatic islets. (NCI)
C34065	Phospholipase-C_Beta-3	Phospholipase	Phospholipase C Beta 3|1-Phosphatidylinositol-4,5-Bisphosphate Phosphodiesterase Beta 3|PLC-Beta-3|PLCB3|Phosphoinositide Phospholipase C|Phospholipase C Beta 3, Phosphatidylinositol-Specific	Expressed in many tissues by human PLCB3 Gene, 1234-aa 139-kDa membrane-bound Phospholipase C Beta 3 contains a catalytic PI-PLC X-box domain, a catalytic PI-PLC Y-box domain, and a C2 domain. Activated in response to stimulation by hormones, growth factors, neurotransmitters, and other ligands, PLCB3 is a key enzyme in initiating receptor-mediated signal transduction by mediating production of DAG and IP3 second messengers. (NCI)
C34066	RBP2-Like_Protein	DNA_Binding_Protein	RBP2-Like Protein|AT Rich Interactive Domain 1B Protein|JARID1B|Jumonji Protein|PLU-1|PLU-1 Protein|PUT1|RBBP2H1A|Retinoblastoma-Binding Protein 2 Homolog 1A	Widely expressed by human PLU-1 Gene (RBBP Family) at varying levels (highest in Sertoli cells), 1544-aa 176-kDa nuclear RBP2-Like Protein contains 3 Cys-rich zinc-binding DNA-binding PHD/LAP domains, a DNA-binding dead ringer domain, 5 putative nuclear localization signals, a putative DNA/chromatin binding motif, and other conserved regions of unknown function. With an additional 137 amino acids, 1681-aa 190-kDa RBBP2H1A appears to be an alternate PLU-1 product that shares 56% overall amino acid sequence identity with RBBP2, important in RB tumor suppressor regulation. (NCI)
C34067	Immediate-Early-Response_Protein-APR	Apoptosis_Promoter	Immediate-Early-Response Protein APR|ATL-Derived PMA-Responsive Protein|Adult T Cell Leukemia-Derived PMA-Responsive Protein|NOXA|PMA-Induced Protein 1|PMAIP1|Phorbol-12-Myristate-13-Acetate-Induced Protein 1	Expressed by PMA-induced, p53-responsive immediate-early-response gene human PMAIP1 Gene, 54-aa Immediate-Early-Response Protein APR contains a BH3 motif and can induce apoptosis in various cells in a BH3-dependent manner. PMAIP1 shows highest similarity to p53- and X-ray responsive 103-aa Noxa protein (mouse) with 2 BH3 motifs. Noxa exhibits BH3-dependent localization to mitochondria and interacts with antiapoptotic BCL2 family proteins, resulting in activation of caspase-9. PMAIP1/Noxa may mediate p53-dependent apoptosis in cells exposed to noxious stresses. (NCI)
C34068	Tripartite_Motif_Protein-TRIM19	Transcription_Factor	Tripartite Motif Protein TRIM19|Inducer of Promyelocytic Leukemia Protein|PML|Promyelocytic Leukemia Protein|TRIM19|Transcription Factor PML	Expressed in a cell-cycle related manner by human PML Gene (TRIM Family), nuclear phosphoprotein Tripartite Motif Protein TRIM19 is a transcription factor and tumor suppressor that regulates the p53 response to oncogenic signals, interacts with SIRT1, and contains a TRIM motif: 3 zinc-binding domains, a RING-type zinc finger, a B-box type 1 zinc finger, a B-box type 2 zinc finger, and a coiled-coil region. Extensive alternative splicing results in fourteen variations of the protein's central and C-terminal regions with an invariant N-terminus. Chromosomal translocation t(15;17)(q21;q21) involving PML and RARA is associated with acute promyelocytic leukemia. (NCI)
C34069	Postmeiotic_Segregation_Increased-2-Like_Protein-1	Protein_with_Unknown_or_Unclassified_Function	Postmeiotic Segregation Increased 2-Like Protein 1|PMS2L1|PMS3|PostmeioticSegregation Increased-2-Like 1
C34070	Cell_Part	Body_Part	Cell Part	The components of the cell.
C34071	DNA-Directed_RNA_Polymerase-II_Polypeptide-A	DNA-Directed_RNA_Polymerase	DNA Directed RNA Polymerase II Polypeptide A|DNA-Directed RNA Polymerase II Largest Subunit|POLR2|POLR2A|POLRA|Polymerase (RNA) II (DNA Directed) Polypeptide A (220kD)|Polymerase (RNA) II (DNA Directed) Polypeptide A, 220kDa|RNA Polymerase II 220 kD Subunit|RPB1|RPBh1|RPO2|RPOL2|RpIILS|hRPB220|hsRPB1	Encoded by human POLR2A Gene (RNA Polymerase Beta Prime Chain Family), nuclear 1970-aa 220-kD DNA Directed RNA Polymerase II Polypeptide A is the largest of 12 subunits of RNA polymerase II that catalyzes transcription of DNA in eukaryotes into mRNA precursor. The C-terminal domain (CTD) heptapeptide repeats contain highly phosphorylated activating serine and threonine residues. POLR2A and other subunits form the polymerase DNA binding domain, where the DNA template is transcribed. POLR2A couples transcription with pre-mRNA processing. The hyperphosphorylated CTD interacts with FNBP3 and recruits factors for mRNA capping, splicing, and 3'-processing. POLR2A interacts with SAFB/SAFB1. POLR2A is ubiquitinated after damage of genes repaired by transcription-coupled repair.  (NCI)
C34072	Polymerization	Biochemical_Reaction	Polymerization	Polymerization consists of enzymatic reactions that form a compound (polymer), usually of high molecular weight, by combination of simpler molecules (monomers).
C34073	L-Type_Amino_Acid_Transporter-3	Transport_Protein	L-Type Amino Acid Transporter 3|LAT3|POV1|Prostate Cancer Overexpressed Protein 1|SLC43A1|Solute Carrier Family 43 Member 1	Expressed in a variety of tissues (fetal liver and adult pancreas highest) by human POV1 Gene, 559-aa L-Type Amino Acid Transporter 3 contains a putative secretory signal peptide and a leucine zipper motif. (NCI)
C34075	Phosphatidic_Acid_Phosphatase_Type-2A	Phosphatase	Phosphatidic Acid Phosphatase Type 2A|PAP2|PAP2A|PPAP2A|Phosphatidic Acid Phosphatase 2A|Phosphatidic Acid Phosphohydrolase Type 2A|Type 2 Phosphatidic Acid Phosphohydrolase|Type-2 Phosphatidic Acid Phosphatase Alpha	Expressed ubiquitously by human PPAP2A Gene (PAP Family), 284-aa 32-kDa Phosphatidic Acid Phosphatase Type 2A is a type 2 integral plasma membrane glycoprotein enzyme with extracellular activity predicted to contain 6 transmembrane regions and a conserved N-glycosylation site. PPAP2A exhibits 47% sequence identity with PPAP2B and 54% identity with PPAP2C; the C-terminal 40-aa of PPAP2A, PPAP2B, and PPAP2C show greatest divergence. PPAP2A has an active role in metabolic pathways controlling synthesis of glycerophospholipids and triacylglycerols, in hydrolysis and uptake of lipids from the extracellular space, in dephosphorylation of phosphatidic acid to diacylglycerol, and in receptor-activated signal transduction mediated by phospholipase D. (NCI)
C34076	Skeletal_System_Part	Other_Anatomic_Concept	Skeletal System Part
C34077	Peroxisome_Proliferative_Activated_Receptor_Gamma	Nuclear_Receptor	Peroxisome Proliferative Activated Receptor Gamma|PPAR Gamma|PPARG|PPARG1|PPARG2	Expressed as multiple variants in adipose tissue (highest), skeletal muscle, spleen, heart, liver placenta, lung, and ovary by human PPARG Gene (NR1/PPAR Family), nuclear Peroxisome Proliferative Activated Receptor Gamma heterodimerizes with RXRs and NCOA6 coactivator to regulate target gene transcription. A receptor that binds peroxisome proliferators, such as hypolipidemic drugs and fatty acids, PPARG is a key regulator of adipocyte differentiation and glucose homeostasis. Once activated by ligand, PPARG binds to an acyl-CoA oxidase gene promoter element, activates transcription, and controls the peroxisomal fatty acid beta-oxidation pathway. Defects in PPARG can lead to type 2 insulin-resistant diabetes and hypertension. (NCI)
C34078	Protein_Serine-Threonine_Phosphatase	Phosphoprotein_Phosphatase	Protein Serine/Threonine Phosphatase	Encoded by Protein Serine/Threonine Phosphatase Genes, Protein Serine/Threonine Phosphatases are a group of enzymes that specifically dephosphorylate phosphoserine and phosphothreonine residues in specific target proteins. Together with serine/threonine protein kinases, these enzymes regulate serine and threonine phosphorylation and dephosphorylation of target proteins in cellular signal transduction pathways typically involved in cell growth control. (NCI)
C34079	Protein_Phosphatase-1_Catalytic_Subunit_Alpha	Protein_Serine-Threonine_Phosphatase	Protein Phosphatase 1 Catalytic Subunit Alpha|PPP1A|PPP1CA|Serine/Threonine Protein Phosphatase PP1-Alpha 1 Catalytic Subunit	Expressed by human PPP1CA Gene (PP1 Family), cytoplasmic Protein Phosphatase 1 Catalytic Subunit Alpha is one of 3 catalytic subunits (A, B, or C) of PP1 folded by IPP2 and GSK3 and then complexed to various targeting or regulatory subunits. PPP1CA is inhibited by IPP1 and IPP2. Protein phosphorylation is crucial in the regulation of many cellular functions; the level of phosphorylation is controlled by the actions of opposing kinases and phosphatases. PP1 is a major serine/threonine-protein phosphatase essential for cell division, regulation of glycogen metabolism, muscle contractility protein synthesis, regulation of ionic conductances, and long-term synaptic plasticity/memory. PPP1CA may dephosphorylate postsynaptic density-associated Ca++/calmodulin dependent protein kinase II. (NCI)
C34080	Protein_Phosphatase-2_Catalytic_Subunit_Alpha	Protein_Serine-Threonine_Phosphatase	Protein Phosphatase 2 Catalytic Subunit Alpha|PP2A-Alpha|PP2CA|PPP2CA|RP-C|Replication Protein C|Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Alpha	Encoded by human PPP2CA Gene (PP1 Family), 309-aa 36-kDa cytoplasmic Protein Phosphatase 2 Catalytic Subunit Alpha forms alpha complexes with a structural PR65/A subunit and beta complexes with an alpha4 protein; association with a regulatory subunit that controls substrate selectivity and activity forms as a specific trimeric holoenzyme. PPP2CA is regulated by inactivating threonine or tyrosine phosphorylation, carboxy methylation, ceramide, and protein inhibitors. Carboxyl methylation may play a role in holoenzyme assembly; it varies during the cell cycle. PP2A can dephosphorylate p53, and modulate phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP2 kinase activity. Core PP2A enzyme consists of the catalytic subunit and a common 65-kDa regulatory subunit; additional regulatory subunits or signaling molecules further modify function. (NCI)
C34081	Protein_Phosphatase-2_Catalytic_Subunit_Beta	Protein_Serine-Threonine_Phosphatase	Protein Phosphatase 2 Catalytic Subunit Beta|PP2A-Beta|PPP2CB|Serine/Threonine Protein Phosphatase 2A Catalytic Subunit Beta	Encoded by human PPP2CB Gene (PP1 Family), ubiquitous 309-aa 36-kDa cytoplasmic serine/threonine-specific Protein Phosphatase 2 Catalytic Subunit Beta forms a core complex with a PR65/A subunit; association with additional regulatory subunits that control substrate selectivity/activity forms as a specific PP2A trimeric holoenzyme. PPP2CB is regulated by inactivating threonine or tyrosine phosphorylation and reversible carboxy methylation. Carboxyl methylation may play a role in holoenzyme assembly; it varies during the cell cycle. PP2A can dephosphorylate p53, and modulate phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP2 kinase activity. In dephosphorylating protein kinases and transcription factors, PPP2CB regulates major metabolic pathways, translation, transcription, and G2/M transition. (NCI)
C34082	Gastrointestinal_Tract	Gastrointestinal_System_Part	Gastrointestinal Tract|Alimentary Canal|Digestive Tract
C34083	Protein_Phosphatase_Regulatory_Protein	Regulatory_Protein	Protein Phosphatase Regulatory Protein	Protein Phosphatase Regulatory Proteins are constant regulatory/scaffolding subunits of PP2 that coordinate assembly of the phosphatase catalytic subunit and various regulatory subunits or cell signaling molecules. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI)
C34084	Protein_Phosphatase-2_Regulatory_Subunit-A_Beta	Protein_Phosphatase_Regulatory_Protein	Protein Phosphatase 2 Regulatory Subunit A Beta|PP2A Subunit A PR65-Beta|PP2A Subunit A R1-Beta|PPP2R1B|Protein Phosphatase 2 Structural/Regulatory Subunit A Beta|Serine/Threonine Protein Phosphatase 2A 65 kDa Regulatory Subunit A Beta	Encoded by human PPP2R1B Gene (PP2A Subunit A Family), 601-aa 66-kDa Protein Phosphatase 2 Regulatory Subunit A Beta contains 15 HEAT repeats that form a rod-like structure consisting of alpha helices joined by a hydrophilic loop. PPP2R1B is a constant regulatory/scaffolding subunit of PP2 that coordinates assembly of the phosphatase catalytic subunit and various regulatory subunits or cell signaling molecules. A major Ser/Thr phosphatase in cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. PPP2R1B interacts with IPO9. (NCI)
C34085	Protein_Phosphatase-2A_Regulatory_Subunit-PR53	Protein_Phosphatase_Regulatory_Protein	Protein Phosphatase 2A Regulatory Subunit PR53|PP2A|PP2A Subunit B Prime|PPP2R4|PR53|PTPA|Phosphotyrosyl Phosphatase Activator|Protein Phosphatase 2A Regulatory Subunit B Prime	Widely expressed (as alpha, beta, delta, and epsilon isoforms) by human PPP2R4 Gene, Protein Phosphatase 2A Regulatory Subunit PR53 is a specific and reversible phosphotyrosyl phosphatase activator of heterodimeric PP2A core enzyme in the presence of ATP and Mg(+2). Implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI)
C34086	Splenic_Tissue	Spleen_Part|Tissue	Splenic Tissue	The largest mass of lymphatic tissue in the body. It consists of cells and vessels contained within a capsule lined by mesothelium, from which trabecula enter the splenic parenchyma. The parenchyma is supported by a framework of reticular fibers. The spleen consists of two types of parenchymal tissue, the white and red pulp. The white pulp is composed of elongated cords of compact lymphatic tissue containing nodules. The red pulp is composed of pulp cords and splenic sinusoids.
C34087	Protein_Phosphatase-2_Regulatory_Subunit-B_Alpha	Protein_Phosphatase_Regulatory_Protein	Protein Phosphatase 2 Regulatory Subunit B Alpha|PP2A B Subunit B Prime Alpha|PP2A B Subunit B56 Alpha|PP2A B Subunit PR61 Alpha|PP2A B Subunit R5 Alpha|PPP2R5A|Protein Phosphatase 2A Regulatory Subunit B56 Alpha|Serine/Threonine Protein Phosphatase 2A 56 kDa Regulatory Subunit Alpha	Ubiquitously expressed (heart and skeletal muscle highest) by human PPP2R5A Gene (PP2A Subunit B Family), serine phosphorylated 486-aa 56-kDa cytoplasmic Protein Phosphatase 2 Regulatory Subunit B Alpha is a subunit of PP2A. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI)
C34088	Protein_Phosphatase-2_Regulatory_Subunit-B_Beta	Protein_Phosphatase_Regulatory_Protein	Protein Phosphatase 2 Regulatory Subunit B Beta|PP2A B Subunit B Prime Beta|PP2A B Subunit B56 Beta|PP2A B Subunit PR61 Beta|PP2A B Subunit R5 Beta|PPP2R5B|Protein Phosphatase 2A Regulatory Subunit B56 Beta|Serine/Threonine Protein Phosphatase 2A 56 kDa Regulatory Subunit Beta	Ubiquitously expressed (highest in brain) as 2 isoforms by human PPP2R5B Gene (PP2A Subunit B Family), serine phosphorylated cytoplasmic Protein Phosphatase 2 Regulatory Subunit B Beta is a regulatory subunit of PP2A. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI)
C34089	Protein_Phosphatase-2_Regulatory_Subunit-B_Gamma	Protein_Phosphatase_Regulatory_Protein	Protein Phosphatase 2 Regulatory Subunit B Gamma|B Prime Alpha Regulatory Subunit|B56G|PP2A B Subunit B Prime Gamma|PP2A B Subunit B56 Gamma|PP2A B Subunit PR61 Gamma|PP2A B Subunit R5 Gamma|PPP2R5C|Protein Phosphatase 2A Regulatory Subunit B56 Gamma|Serine/Threonine Protein Phosphatase 2A 56 kDa Regulatory Subunit Gamma	Ubiquitously expressed as 3 isoforms by human PPP2R5C Gene (PP2A Subunit B Family), Protein Phosphatase 2 Regulatory Subunit B Gamma is a regulatory subunit of PP2A. Nuclear Gamma-3 is serine phosphorylated, while nuclear Gamma-1 is not. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI)
C34090	Protein_Phosphatase-2_Regulatory_Subunit-B_Delta	Protein_Phosphatase_Regulatory_Protein	Protein Phosphatase 2 Regulatory Subunit B Delta|PP2A B Subunit B Prime Delta|PP2A B Subunit B56 Delta|PP2A B Subunit PR61 Delta|PP2A B Subunit R5 Delta|PPP2R5D|Protein Phosphatase 2A Regulatory Subunit B56 Delta|Serine/Threonine Protein Phosphatase 2A 56 kDa Regulatory Subunit Delta	Widely expressed (high in brain) as 3 isoforms by human PPP2R5D Gene (PP2A Subunit B Family), 70-kDa Protein Phosphatase 2 Regulatory Subunit B Delta is a cytoplasmic and nuclear regulatory subunit of PP2A in interphase, but nuclear in mitosis. PPP2R5D-1 is serine phosphorylated. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI)
C34091	Protein_Phosphatase-2_Regulatory_Subunit-B_Epsilon	Protein_Phosphatase_Regulatory_Protein	Protein Phosphatase 2 Regulatory Subunit B Epsilon|PP2A B Subunit B Prime Epsilon|PP2A B Subunit B56 Epsilon|PP2A B Subunit PR61 Epsilon|PP2A B Subunit R5 Epsilon|PPP2R5E|Protein Phosphatase 2A Regulatory Subunit B56 Epsilon|Serine/Threonine Protein Phosphatase 2A 56 kDa Regulatory Subunit Epsilon	Encoded as two isoforms by human PPP2R5E Gene (Phosphatase 2A Regulatory Subunit B Family), serine phosphorylated 55-kD Protein Phosphatase 2 Regulatory Subunit B Epsilon is a regulatory subunit of PP2A. PPP2R5E is predominantly concentrated in the perinuclear cytoplasm and excluded from the nucleus. A major Ser/Thr phosphatase implicated in negative control of cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression. (NCI)
C34092	PR-Domain_Zinc_Finger_Protein-1	Transcription_Repressor_Corepressor	PR-Domain Zinc Finger Protein 1|B-Lymphocyte-Induced Maturation Protein 1|BLIMP1|Beta-Interferon Gene Positive-Regulatory Domain I Binding Factor|PR Domain Containing 1 with ZNF Domain Protein|PRDI-BF1|PRDI-Binding Factor-1|PRDM1|Positive Regulatory Domain I-Binding Factor 1	Expression by human PRDM1 Gene increased on virus induction, 789-aa 88-kDa PR-Domain Zinc Finger Protein 1 is a transcriptional repressor containing a SET domain and 4 C2H2-type zinc fingers. PRDM1 specifically binds to the PRDI (positive regulatory domain I) element of the beta-IFN gene promoter and represses beta-interferon gene expression. PRDM1 also drives maturation of B lymphocytes into Ig secreting cells. (NCI)
C34093	PR-Domain_Zinc_Finger_Protein-4	Transcription_Factor	PR-Domain Zinc Finger Protein 4|PFM1|PR Domain Containing 4 Protein|PR-Domain Zinc-Finger Protein PFM1|PRDM4	Widely expressed (high in ovary, testis, pancreas, brain, heart, and prostate) by human PRDM4 Gene (PR-Domain Family), 801-aa 88-kDa transcription factor PR-Domain Zinc Finger Protein 4 contains a PR-domain, a SET domain, and multiple zinc finger motifs. PR-domain transcription factors are typically involved in cell differentiation. (NCI)
C34094	Type-II_cGMP-Dependent_Protein_Kinase	Signaling_Protein	Type II cGMP-Dependent Protein Kinase|CGK2|CGKII|PRKG2|PRKGR2|Q13237|cGMP-Dependent Protein Kinase 2|cGMP-Dependent Type II Protein Kinase	Highly expressed in brain, lung, prostate, thymus, and intestinal mucosa by human PRKG2 Gene (cGMP Ser/Thr Kinase Family), 762-aa 87-kDa Type II cGMP-Dependent Protein Kinase is a physiologic mediator of cGMP and contains 2 cyclic nucleotide-binding domains. Type I and II cGMP-dependent protein kinases are encoded by distinct genes. Human cGKII is 96% identical to mouse and rat cGKII. Though not well understood, cGKII function may mediate intestinal secretion of water and electrolytes. NO and diverse hormones, drugs, and toxins increase intracellular cGMP to activate receptors that regulate a variety of functions, including smooth muscle relaxation, neuronal excitability, and epithelial electrolyte transport. (NCI)
C34095	Interferon-Inducible_elF2Alpha_Kinase	Serine-Threonine_Protein_Kinase	Interferon-Inducible elF2Alpha Kinase|EIF2AK1|Interferon-Induced Double-Stranded RNA-Activated Protein Kinase|Interferon-Inducible Double Stranded RNA Dependent Protein Kinase|Interferon-Inducible RNA-Dependent Protein Kinase|P1/eIF2A Protein Kinase|PKR|PRKR|p68 Kinase	Expressed by interferon-induced human PRKR Gene (GCN2 Family), 551-aa 62-kDa Interferon-Inducible elF2Alpha Kinase is a homodimeric serine/threonine protein kinase containing 2 DRBM domains that is activated by double-stranded RNA in the presence of ATP. Binding to dsRNA induces PRKR dimerization and activation, leading to autophosphorylation in the activation loop, PRKR phosphorylation of EIF2-alpha, and inhibition of protein synthesis initiation. P58(IPK) inhibition by P52(rIPK) upregulates PRKR activity. IFNG mRNA activates PRKR through a conserved 5-prime UTR pseudoknot to control its own translation yield. HCV envelope protein E2 contains a sequence identical to phosphorylation sites of PRKR and EIF2-alpha. E2 inhibits PRKR inhibitory activity on protein synthesis and cell growth, which may contribute to HCV-associated hepatocellular carcinoma. (NCI)
C34096	Transcriptional_Coactivator-p52	Transcription_Coactivator	Transcriptional Coactivator p52|PAIP|PC4 and SFRS1 Interacting Protein 1|PC4 and SFRS1 Interacting Protein 2|PSIP1|PSIP2|p52	Encoded by human PSIP1 Gene, Transcriptional Coactivator p52 is an alternatively spliced product that shares a 325-aa region with Transcriptional Coactivator p75, but shows distinct coactivator properties. p52 interacts strongly with the VP16 activation domain and with components of the general transcriptional machinery. A potent broad-specificity coactivator, p52 interacts with transcriptional activators and general transcription factors, as well as with ASF/SF2 to modulate pre-mRNA splicing. Most p52 appears to be colocalized with ASF/SF2 in the nucleoplasm. p52 may coordinate pre-mRNA splicing and transcriptional activation of class II genes. (NCI)
C34097	Transcriptional_Coactivator-p75	Transcription_Coactivator	Transcriptional Coactivator p75|PAIP|PC4 and SFRS1 Interacting Protein 1|PC4 and SFRS1 Interacting Protein 2|PSIP1|PSIP2|p75	Encoded by human PSIP1 Gene, Transcriptional Coactivator p75 is an alternatively spliced product that shares a 325-aa region with Transcriptional Coactivator p52, but shows distinct coactivator properties. p75 interacts strongly with the VP16 activation domain. p52 is a potent broad-specificity coactivator; p75 is less active for most activation domains. (NCI)
C34098	Patched_Homolog-2_Protein	Signaling_Protein	Patched Homolog 2|PTC2|PTCH2|Patched 2|Patched Protein Homolog 2	Encoded by human PTCH2 Gene (Patched Family), 1203-aa transmembrane protein Patched Homolog 2 is a possible sonic hedgehog receptor, highly similar to PTCH and containing an SSD domain, that may have a role formation of embryonic structures and in epidermal development. The Drosophila patched-hedgehog signaling pathway establishes segment polarity and anterior-posterior orientation. The patched pathway is conserved from fly to vertebrates. With 56% identity to Patched-1, mouse Patched-2 diverges in the hydrophilic region between transmembrane domains 6 and 7 and in a region of the intracellular C terminus. (NCI)
C34099	PTK6_Protein_Tyrosine_Kinase-6	Protein_Tyrosine_Kinase	PTK6 Protein Tyrosine Kinase 6|BRK|Breast Tumor Kinase|PTK6|Protein-Tyrosine Kinase BRK|Tyrosine-Protein Kinase 6|Tyrosine-Protein Kinase BRK	Expressed in colon, small intestine, prostate, melanocytes, and some fetal tissues by human PTK6 Gene (BRK/PTK6/SIK Family), PTK6 Protein Tyrosine Kinase 6 is an autophosphorylated cytoplasmic nonreceptor protein tyrosine kinase containing an SH2 domain and an SH3 domain that may function as an intracellular signal transducer in epithelial tissues. (NCI)
C34100	Embryonic	Anatomy_Modifier	Embryonic|embryonic	Having to do with an embryo, which is an early stage in the development of a plant or animal.
C34101	Allantois	Other_Embryologic_Structure	Allantois
C34102	Amniotic_Cavity	Other_Embryologic_Structure	Amniotic Cavity
C34103	Amniotic_Sac	Other_Embryologic_Structure	Amniotic Sac
C34104	Amniotic_Surface_of_the_Placenta	Other_Embryologic_Structure	Amniotic Surface of the Placenta|Amniotic Surface of Placenta
C34105	Anal_Membrane	Other_Embryologic_Structure	Anal Membrane
C34106	Angioblastic_Cord	Other_Embryologic_Structure	Angioblastic Cord
C34107	Anocutaneous_Line	Other_Embryologic_Structure	Anocutaneous Line
C34108	Anterior_Cardinal_Vein	Cardinal_Vein	Anterior Cardinal Vein
C34109	Apical_Ectodermal_Ridge	Other_Embryologic_Structure	Apical Ectodermal Ridge
C34110	Auricular_Hillock	Other_Embryologic_Structure	Auricular Hillock
C34111	Basal_Plate	Other_Embryologic_Structure	Basal Plate
C34112	Bilaminar_Embryonic_Disc	Embryonic_Disc	Bilaminar Embryonic Disc
C34113	Blood_Island	Other_Embryologic_Structure	Blood Island
C34114	Bulbus_Cordis	Other_Embryologic_Structure	Bulbus Cordis
C34115	Cardiac_Jelly	Other_Embryologic_Structure	Cardiac Jelly
C34116	Cardinal_Vein	Embryonic_Vein	Cardinal Vein
C34117	Caudal_Ridge	Other_Embryologic_Structure	Caudal Ridge
C34118	Cecal_Diverticulum	Other_Embryologic_Structure	Cecal Diverticulum
C34119	Central_Tendon_of_the_Diaphragm	Other_Embryologic_Structure	Central Tendon of the Diaphragm|Central Tendon of Diaphragm
C34120	Chondrification_Center	Other_Embryologic_Structure	Chondrification Center
C34121	Chondrocranium	Other_Embryologic_Structure	Chondrocranium
C34122	Chorion	Extraembryonic_Structure	Chorion
C34123	Chorionic_Plate	Other_Embryologic_Structure	Chorionic Plate
C34124	Chorionic_Sac	Extraembryonic_Structure	Chorionic Sac
C34125	Chorionic_Villus	Extraembryonic_Structure	Chorionic Villus
C34126	Chyle_Cistern	Other_Embryologic_Structure	Chyle Cistern
C34127	Cloaca	Other_Embryologic_Structure	Cloaca
C34128	Cloacal_Membrane	Other_Embryologic_Structure	Cloacal Membrane
C34129	Cloacal_Sphincter	Other_Embryologic_Structure	Cloacal Sphincter
C34130	Common_Cardinal_Vein	Cardinal_Vein	Common Cardinal Vein
C34131	Conceptus	Embryo	Conceptus
C34132	Connecting_Stalk	Extraembryonic_Structure	Connecting Stalk
C34133	Connective_Tissue_of_Villus	Other_Embryologic_Structure	Connective Tissue of Villus
C34134	Cortical_Cord	Other_Embryologic_Structure	Cortical Cord
C34135	Cotyledon	Other_Embryologic_Structure	Cotyledon
C34136	Cranial_Ridge	Other_Embryologic_Structure	Cranial Ridge
C34137	Cytotrophoblastic_Shell	Other_Embryologic_Structure	Cytotrophoblastic Shell
C34138	Dental_Sac	Other_Embryologic_Structure	Dental Sac
C34139	Dermatome_Region	Other_Embryologic_Structure	Dermatome Region
C34140	Dermomyotome	Other_Embryologic_Structure	Dermomyotome
C34141	Digital_Ray	Other_Embryologic_Structure	Digital Ray
C34142	Dorsal_Mesogastrium	Other_Embryologic_Structure	Dorsal Mesogastrium
C34143	Ductus_Venosus	Embryonic_Vein	Ductus Venosus
C34144	Embryologic_Structure_or_System	Anatomic_Structure_System_or_Substance	Embryologic Structure or System
C34145	Embryonic_Artery	Other_Embryologic_Structure	Embryonic Artery
C34146	Embryonic_Atrium	Other_Embryologic_Structure	Embryonic Atrium
C34147	Embryonic_Body_Cavity	Other_Embryologic_Structure	Embryonic Body Cavity
C34148	Embryonic_Cardiovascular_System	Other_Embryologic_Structure	Embryonic Cardiovascular System
C34149	Embryonic_Digestive_System	Other_Embryologic_Structure	Embryonic Digestive System
C34150	Embryonic_Disc	Other_Embryologic_Structure	Embryonic Disc
C34151	Embryonic_Ear	Other_Embryologic_Structure	Embryonic Ear
C34152	Embryonic_Eye	Other_Embryologic_Structure	Embryonic Eye
C34153	Embryonic_Heart	Other_Embryologic_Structure	Embryonic Heart
C34154	Embryonic_Integumentary_System	Other_Embryologic_Structure	Embryonic Integumentary System
C34155	Embryonic_Muskuloskeletal_System	Other_Embryologic_Structure	Embryonic Muskuloskeletal System
C34156	Embryonic_Nervous_System	Other_Embryologic_Structure	Embryonic Nervous System
C34157	Embryonic_Palate	Other_Embryologic_Structure	Embryonic Palate
C34158	Embryonic_Respiratory_System	Other_Embryologic_Structure	Embryonic Respiratory System
C34159	Embryonic_Vein	Other_Embryologic_Structure	Embryonic Vein
C34160	Embryonic_Ventricle	Other_Embryologic_Structure	Embryonic Ventricle
C34161	Endocardial_Heart_Tube	Other_Embryologic_Structure	Endocardial Heart Tube
C34162	Endothelium_of_the_Fetal_Capillary	Other_Embryologic_Structure	Endothelium of the Fetal Capillary|Endothelium of Fetal Capillary
C34163	Epaxial_Division_of_the_Myotome	Other_Embryologic_Structure	Epaxial Division of the Myotome|Epaxial Division of Myotome
C34164	Epiblast	Other_Embryologic_Structure	Epiblast
C34165	Extraembryonic_Coelom	Extraembryonic_Structure	Extraembryonic Coelom
C34166	Fetal_Gastrointestinal_Tract	Other_Embryologic_Structure	Fetal Gastrointestinal Tract
C34167	Fetal_Heart	Other_Embryologic_Structure	Fetal Heart
C34168	Fetal_Kidney	Other_Embryologic_Structure	Fetal Kidney
C34169	Fetal_Liver	Other_Embryologic_Structure	Fetal Liver
C34170	Fetal_Lung	Other_Embryologic_Structure	Fetal Lung
C34171	Fetal_Skeleton	Other_Embryologic_Structure	Fetal Skeleton
C34172	Fetal_Skull	Other_Embryologic_Structure	Fetal Skull
C34173	Fetal_Spleen	Other_Embryologic_Structure	Fetal Spleen
C34174	Fifth_Pharyngeal_Pouch	Pharyngeal_Pouch	Fifth Pharyngeal Pouch
C34175	First_Pharyngeal_Arch	Pharyngeal_Arch	First Pharyngeal Arch
C34176	First_Pharyngeal_Pouch	Pharyngeal_Pouch	First Pharyngeal Pouch
C34177	Foot_Plate	Other_Embryologic_Structure	Foot Plate
C34178	Foramen_Primum	Other_Embryologic_Structure	Foramen Primum
C34179	Foramen_Secundum	Other_Embryologic_Structure	Foramen Secundum
C34180	Foregut	Other_Embryologic_Structure	Foregut
C34181	Fourth_Pharyngeal_Pouch	Pharyngeal_Pouch	Fourth Pharyngeal Pouch
C34182	Frontonasal_Prominence	Other_Embryologic_Structure	Frontonasal Prominence
C34183	Gonadal_Cord	Other_Embryologic_Structure	Gonadal Cord
C34184	Gonadal_Ridge	Other_Embryologic_Structure	Gonadal Ridge
C34185	Hand_Plate	Other_Embryologic_Structure	Hand Plate
C34186	Hepatic_Cord	Other_Embryologic_Structure	Hepatic Cord
C34187	Hepatic_Diverticulum	Other_Embryologic_Structure	Hepatic Diverticulum
C34188	Hindgut	Other_Embryologic_Structure	Hindgut
C34189	Hypaxial_Division_of_the_Myotome	Other_Embryologic_Structure	Hypaxial Division of the Myotome|Hypaxial Division of Myotome
C34190	Hypoblast	Other_Embryologic_Structure	Hypoblast
C34191	Iliac_Lymph_Sac	Primary_Lymph_Sac	Iliac Lymph Sac
C34192	Indifferent_Gonad	Other_Embryologic_Structure	Indifferent Gonad
C34193	Intermediate_Mesoderm	Mesoderm	Intermediate Mesoderm
C34194	Interventricular_Foramen	Other_Embryologic_Structure	Interventricular Foramen
C34195	Intraembryonic_Coelom	Other_Embryologic_Structure	Intraembryonic Coelom
C34196	Jugular_Lymph_Sac	Primary_Lymph_Sac	Jugular Lymph Sac
C34197	Lanugo	Other_Embryologic_Structure	Lanugo
C34198	Laryngotracheal_Tube	Other_Embryologic_Structure	Laryngotracheal Tube
C34199	Lateral_Mesoderm	Mesoderm	Lateral Mesoderm
C34200	Left_Brachiocephalic_Vein	Embryonic_Vein	Left Brachiocephalic Vein
C34201	Lens_Pit	Other_Embryologic_Structure	Lens Pit
C34202	Lens_Placodes	Other_Embryologic_Structure	Lens Placodes
C34203	Limb_Bud	Other_Embryologic_Structure	Limb Bud
C34204	Mandibular_Prominence	Other_Embryologic_Structure	Mandibular Prominence
C34205	Maxillary_Artery	Embryonic_Artery	Maxillary Artery
C34206	Maxillary_Prominence	Other_Embryologic_Structure	Maxillary Prominence
C34207	Metanephric_Diverticulum	Other_Embryologic_Structure	Metanephric Diverticulum|Ureteric Bud
C34208	Metanephric_Mass_of_the_Intermediate_Mesoderm	Other_Embryologic_Structure	Metanephric Mass of the Intermediate Mesoderm|Metanephrogenic Blastema
C34209	Metanephros	Other_Embryologic_Structure	Metanephros|Primordium of Permanent Kidney
C34210	Midgut	Other_Embryologic_Structure	Midgut
C34211	Midgut_Loop	Other_Embryologic_Structure	Midgut Loop
C34212	Morula	Embryo	Morula
C34213	Mucous_Connective_Tissue	Embryonic_Connective_Tissue	Mucous Connective Tissue|Wharton's Jelly
C34214	Myotome_Region	Other_Embryologic_Structure	Myotome Region
C34215	Nail_Fold	Other_Embryologic_Structure	Nail Fold
C34216	Nail_Plate	Other_Embryologic_Structure	Nail Plate
C34217	Nasal_Prominence	Other_Embryologic_Structure	Nasal Prominence
C34218	Nasolacrimal_Groove	Other_Embryologic_Structure	Nasolacrimal Groove
C34219	Nephrogenic_Cord	Other_Embryologic_Structure	Nephrogenic Cord|Nephrogenic Ridge
C34220	Nerve_of_the_Pharyngeal_Arch	Other_Embryologic_Structure	Nerve of the Pharyngeal Arch|Nerve of Pharyngeal Arch
C34221	Neural_Canal	Other_Embryologic_Structure	Neural Canal
C34222	Neural_Crest	Other_Embryologic_Structure	Neural Crest
C34223	Neural_Fold	Other_Embryologic_Structure	Neural Fold
C34224	Neural_Groove	Other_Embryologic_Structure	Neural Groove
C34225	Neural_Plate	Other_Embryologic_Structure	Neural Plate
C34226	Neural_Tube	Other_Embryologic_Structure	Neural Tube
C34227	Neurenteric_Canal	Other_Embryologic_Structure	Neurenteric Canal
C34228	Neuroectoderm	Ectoderm|Neuroepithelial_Tissue	Neuroectoderm	The dorsal surface of the early vertebrate embryo that gives rise to the nervous system.
C34229	Neurula	Embryo	Neurula
C34230	Notochordal_Canal	Other_Embryologic_Structure	Notochordal Canal
C34231	Notochordal_Plate	Other_Embryologic_Structure	Notochordal Plate
C34232	Notochordal_Process	Other_Embryologic_Structure	Notochordal Process
C34233	Optic_Cup	Other_Embryologic_Structure	Optic Cup
C34234	Optic_Groove	Other_Embryologic_Structure	Optic Groove
C34235	Optic_Stalk	Other_Embryologic_Structure	Optic Stalk
C34236	Optic_Vesicle	Other_Embryologic_Structure	Optic Vesicle
C34237	Other_Embryologic_Structure	Embryologic_Structure_or_System	Other Embryologic Structure
C34238	Otic_Pit	Other_Embryologic_Structure	Otic Pit
C34239	Otic_Placodes	Other_Embryologic_Structure	Otic Placodes
C34240	Otic_Vesicle	Other_Embryologic_Structure	Otic Vesicle
C34241	Oval_Foramen	Other_Embryologic_Structure	Oval Foramen
C34242	Pancreatic_Bud	Other_Embryologic_Structure	Pancreatic Bud
C34243	Parachordal_Cartilage	Other_Embryologic_Structure	Parachordal Cartilage
C34244	Paraxial_Mesoderm	Mesoderm	Paraxial Mesoderm
C34245	Pectinate_Line	Other_Embryologic_Structure	Pectinate Line
C34246	Pericardioperitoneal_Canal	Other_Embryologic_Structure	Pericardioperitoneal Canal
C34247	Periderm	Other_Embryologic_Structure	Periderm
C34248	Pharyngeal_Apparatus	Other_Embryologic_Structure	Pharyngeal Apparatus
C34249	Pharyngeal_Arch	Other_Embryologic_Structure	Pharyngeal Arch
C34250	Pharyngeal_Groove	Other_Embryologic_Structure	Pharyngeal Groove
C34251	Pharyngeal_Membrane	Other_Embryologic_Structure	Pharyngeal Membrane
C34252	Pharyngeal_Pouch	Other_Embryologic_Structure	Pharyngeal Pouch
C34253	Placental_Membrane	Other_Embryologic_Structure	Placental Membrane
C34254	Placental_Septum	Other_Embryologic_Structure	Placental Septum|Desidual Septum
C34255	Pleuropericardial_Membrane	Other_Embryologic_Structure	Pleuropericardial Membrane
C34256	Pleuroperitoneal_Membrane	Other_Embryologic_Structure	Pleuroperitoneal Membrane
C34257	Posterior_Cardinal_Vein	Cardinal_Vein	Posterior Cardinal Vein
C34258	Primordial_Uteroplacental_Circulation	Extraembryonic_Structure	Primordial Uteroplacental Circulation
C34259	Primary_Brain_Vesicle	Other_Embryologic_Structure	Primary Brain Vesicle|Primary Cerebral Vesicle
C34260	Primary_Bronchial_Bud	Other_Embryologic_Structure	Primary Bronchial Bud
C34261	Primary_Chorionic_Villus	Chorionic_Villus	Primary Chorionic Villus
C34262	Primary_Lymph_Sac	Other_Embryologic_Structure	Primary Lymph Sac
C34263	Primary_Ossification_Center	Other_Embryologic_Structure	Primary Ossification Center
C34264	Primary_Palate	Embryonic_Palate	Primary Palate
C34265	Primitive_Groove	Other_Embryologic_Structure	Primitive Groove
C34266	Primitive_Node	Other_Embryologic_Structure	Primitive Node
C34267	Primitive_Pit	Other_Embryologic_Structure	Primitive Pit
C34268	Primordial_Gut	Other_Embryologic_Structure	Primordial Gut
C34269	Primordial_Interventricular_Septum	Other_Embryologic_Structure	Primordial Interventricular Septum
C34270	Primordial_Laryngeal_Inlet	Other_Embryologic_Structure	Primordial Laryngeal Inlet
C34271	Primordial_Mediastinum	Other_Embryologic_Structure	Primordial Mediastinum
C34272	Primordial_Myocardium	Other_Embryologic_Structure	Primordial Myocardium
C34273	Primordial_Optic_Nerve	Other_Embryologic_Structure	Primordial Optic Nerve
C34274	Primordial_Phallus	Other_Embryologic_Structure	Primordial Phallus
C34275	Primordium	Other_Embryologic_Structure	Primordium
C34276	Primordium_of_the_Heart	Other_Embryologic_Structure	Primordium of the Heart|Primordium of Heart
C34277	Primordium_of_the_Liver	Other_Embryologic_Structure	Primordium of the Liver|Primordium of Liver
C34278	Proctodeum	Other_Embryologic_Structure	Proctodeum|Anal Pit
C34279	Pronephric_Duct	Other_Embryologic_Structure	Pronephric Duct
C34280	Pronephros	Other_Embryologic_Structure	Pronephros
C34281	Rathke_s_Pouch	Other_Embryologic_Structure	Rathke's Pouch
C34282	Respiratory_Diverticulum	Other_Embryologic_Structure	Respiratory Diverticulum
C34283	Respiratory_Primordium	Other_Embryologic_Structure	Respiratory Primordium
C34284	Retinal_Fissure	Other_Embryologic_Structure	Retinal Fissure
C34285	Retroperitoneal_Lymph_Sac	Primary_Lymph_Sac	Retroperitoneal Lymph Sac
C34286	Scalp_Vascular_Plexus	Other_Embryologic_Structure	Scalp Vascular Plexus
C34287	Sclerotome	Other_Embryologic_Structure	Sclerotome
C34288	Second_Pharyngeal_Arch	Pharyngeal_Arch	Second Pharyngeal Arch|Hyoid Arch
C34289	Second_Pharyngeal_Pouch	Pharyngeal_Pouch	Second Pharyngeal Pouch
C34290	Secondary_Brain_Vesicle	Other_Embryologic_Structure	Secondary Brain Vesicle
C34291	Secondary_Chorionic_Villus	Chorionic_Villus	Secondary Chorionic Villus
C34292	Secondary_Palate	Embryonic_Palate	Secondary Palate
C34293	Seminiferous_Cord	Other_Embryologic_Structure	Seminiferous Cord
C34294	Septum_Primum	Other_Embryologic_Structure	Septum Primum
C34295	Septum_Secundum	Other_Embryologic_Structure	Septum Secundum
C34296	Septum_Transversum	Other_Embryologic_Structure	Septum Transversum
C34297	Sinovaginal_Bulb	Other_Embryologic_Structure	Sinovaginal Bulb
C34298	Sinus_Tubercle	Other_Embryologic_Structure	Sinus Tubercle|Muller Tubercle
C34299	Sinus_Venarum	Other_Embryologic_Structure	Sinus Venarum
C34300	Sinus_Venosus	Other_Embryologic_Structure	Sinus Venosus
C34301	Somatopleure	Other_Embryologic_Structure	Somatopleure
C34302	Somite	Other_Embryologic_Structure	Somite
C34303	Splanchnopleure	Other_Embryologic_Structure	Splanchnopleure
C34304	Stapedial_Artery	Embryonic_Artery	Stapedial Artery
C34305	Stomach_Primordium	Other_Embryologic_Structure	Stomach Primordium
C34306	Stomodeum	Other_Embryologic_Structure	Stomodeum|Primordial Mouth
C34307	Subcardinal_Vein	Embryonic_Vein	Subcardinal Vein
C34308	Supracardinal_Vein	Embryonic_Vein	Supracardinal Vein
C34309	Surface_Ectoderm	Ectoderm	Surface Ectoderm
C34310	Tertiary_Chorionic_Villus	Chorionic_Villus	Tertiary Chorionic Villus
C34311	Third_Pharyngeal_Pouch	Pharyngeal_Pouch	Third Pharyngeal Pouch
C34312	Thyroid_Primordium	Other_Embryologic_Structure	Thyroid Primordium
C34313	Tooth_Bud	Other_Embryologic_Structure	Tooth Bud
C34314	Tracheal_Bud	Other_Embryologic_Structure	Tracheal Bud
C34315	Tracheoesophageal_Fold	Other_Embryologic_Structure	Tracheoesophageal Fold
C34316	Tracheoesophageal_Septum	Other_Embryologic_Structure	Tracheoesophageal Septum
C34317	Trancus_Arteriosus	Embryonic_Artery	Trancus Arteriosus
C34318	Tubotympanic_Recess	Other_Embryologic_Structure	Tubotympanic Recess
C34319	Umbilical_Blood	Other_Embryologic_Structure	Umbilical Blood
C34320	Umbilical_Cord	Extraembryonic_Structure	Umbilical Cord
C34321	Urogenital_Ridge	Other_Embryologic_Structure	Urogenital Ridge
C34322	Urogenital_Sinus	Other_Embryologic_Structure	Urogenital Sinus
C34323	Urorectal_Septum	Other_Embryologic_Structure	Urorectal Septum
C34324	Uterovaginal_Primordium	Other_Embryologic_Structure	Uterovaginal Primordium
C34325	Vaginal_Plate	Other_Embryologic_Structure	Vaginal Plate
C34326	Valve_of_the_Oval_Foramen	Other_Embryologic_Structure	Valve of the Oval Foramen|Valve of Oval Foramen
C34327	Ventral_Mesogastrium	Other_Embryologic_Structure	Ventral Mesogastrium
C34328	Vernix_Caseosa	Other_Embryologic_Structure	Vernix Caseosa
C34329	Vitelline_Vein	Embryonic_Vein	Vitelline Vein
C34330	PTK7_Protein_Tyrosine_Kinase-7	Transmembrane_Protein	PTK7 Protein Tyrosine Kinase 7|CCK4|Colon Carcinoma Kinase-4|PTK7|Protein-Tyrosine Kinase PTK7|Tyrosine-Protein Kinase-Like 7	Expressed in lung, liver, pancreas, kidney, placenta, melanocytes, thyroid gland, ovary, brain, heart, and skeletal muscle (but not in colon) by human PTK7 Gene (INSR family), 1070-aa 118-kDa (precursor) PTK7 Protein Tyrosine Kinase 7 is a type I membrane protein containing 7 Ig-like C2-type domains that appears to lack tyrosine kinase catalytic activity and may function as a cell adhesion molecule. PTK7 may be a colon carcinoma tumor progression marker. (NCI)
C34331	Abdominal_Cramp	Muscle_Cramp	Abdominal Cramp
C34332	Abdominal_Injury	Injury	Abdominal Injury
C34333	Abdominal_Mass	Mass	Abdominal Mass
C34334	Abnormal_Hard_Tissue_Formation_in_Pulp	Dental_Disorder	Abnormal Hard Tissue Formation in Pulp
C34336	Spontaneous_Abortion	Abortion	Spontaneous Abortion	the natural premature expulsion from the uterus of the products of conception, the embryo, or non-viable fetus.
C34337	Illegal_Abortion	Abortion	Illegal Abortion|Criminal Abortion
C34338	Therapeutic_Abortion	Abortion	Therapeutic Abortion|Pregnancy Termination
C34339	Legally_Induced_Abortion	Abortion	Legally Induced Abortion
C34340	Accident	Injury	Accident	an unforeseen and unplanned event or circumstance frequently causing loss or injury.
C34341	Aircraft_Accident	Accident	Aircraft Accident
C34342	Domestic_Accident	Accident	Domestic Accident
C34343	Industrial_Accident	Accident	Industrial Accident
C34344	Automobile_Accident	Accident	Automobile Accident
C34345	Achondroplasia	Non-Neoplastic_Bone_Disorder	Achondroplasia	An autosomal dominant disorder that is the most frequent form of short-limb dwarfism. Affected individuals exhibit short stature caused by rhizomelic shortening of the limbs, characteristic facies with frontal bossing and mid-face hypoplasia, exaggerated lumbar lordosis, limitation of elbow extension, genu varum, and trident hand. (MeSH)
C34346	Acne_Keloid	Keloid	Acne Keloid|Keloidal Folliculitis
C34347	Acquired_Coagulation_Factor_Deficiency	Coagulation_Factor_Deficiency	Acquired Coagulation Factor Deficiency
C34348	Acrocephalosyndactyly	Congenital_Abnormality	Acrocephalosyndactyly
C34349	Actinomycetoma	Actinomycosis	Actinomycetoma
C34350	Actinomycosis	Bacterial_Infection	Actinomycosis
C34351	Cervicofacial_Actinomycotic_Infection	Actinomycosis	Cervicofacial Actinomycotic Infection
C34352	Acute_Alcoholic_Hepatitis	Acute_Hepatitis|Alcoholic_Hepatitis	Acute Alcoholic Hepatitis
C34353	Acute_Atopic_Conjunctivitis	Acute_Conjunctivitis|Atopic_Conjunctivitis	Acute Atopic Conjunctivitis
C34354	Acute_Periodontitis	Periodontitis	Acute Periodontitis
C34355	Acute_Pharyngitis	Pharyngitis	Acute Pharyngitis
C34356	Acute_Intestinal_Ischemia	Ischemic_Bowel_Disease	Acute Intestinal Ischemia
C34357	Holmes-Adie_Syndrome	Syndrome	Holmes-Adie Syndrome
C34358	Adjustment_Reaction_with_Brief_Depressive_Reaction	Reactive_Depression	Adjustment Reaction with Brief Depressive Reaction
C34359	Adnexitis	Pelvic_Inflammatory_Disease	Adnexitis|Uterine Adnexitis
C34360	Congenital_Adrenal_Hyperplasia	Congenital_Adrenal_Gland_Disorder	Congenital Adrenal Gland Hyperplasia|Congenital Adrenal Hyperplasia	a group of syndromes caused by inherited defects in cortisol and/or aldosterone biosynthesis; ACTH elevation is caused by low levels of cortisol, whose production is impaired by absence or deficiency of one of the five enzymes necessary for its synthesis from cholesterol.
C34361	Affective_Psychosis	Psychiatric_Disorder	Affective Psychosis
C34362	Agoraphobia	Phobia	Agoraphobia	intense, irrational fear of open spaces, characterized by marked fear of being alone or of being in public places where escape would be difficult or help might not be available.
C34363	Agoraphobia_without_a_History_of_Panic_Disorder	Phobia	Agoraphobia without a History of Panic Disorder
C34364	Air_Sickness	Motion_Sickness	Air Sickness
C34365	Alastrim	Smallpox	Alastrim
C34366	Alcohol-Induced_Wernicke-Korsakoff_s_Syndrome	Wernicke-Korsakoff_Syndrome	Alcohol-Induced Wernicke-Korsakoff's Syndrome|Alcohol-Induced Amnestic Syndrome|Alcoholic Korsakoff's Psychosis
C34367	Alcohol_Intoxication	Intoxication	Alcohol Intoxication
C34368	Alpha_Thalassemia	Thalassemia	Alpha Thalassemia|Hemoglobin H Disease
C34369	Extrinsic_Allergic_Alveolitis	Alveolitis	Extrinsic Allergic Alveolitis|Allergic Pneumonitis|Hypersensitivity Pneumonitis	conditions in which inhalation of organic dusts results in hypersensitivity reactions at the alveolar level, associated with the production of precipitins.
C34370	Amelia	Ectromelia	Amelia
C34371	Ametropia	Vision_Disorder	Ametropia
C34372	Retrograde_Amnesia	Amnesia	Retrograde Amnesia
C34373	Amyotrophic_Lateral_Sclerosis	Neurodegenerative_Disorder	Amyotrophic Lateral Sclerosis|ALS|Lou Gehrig Disease	progressive degeneration of the neurons that give rise to the corticospinal tract and of the motor cells of the brain stem and spinal cord, resulting in a deficit of upper and lower motor neurons.
C34374	Ancylostomiasis_due_to_Ancylostoma_Duodenale	Ancylostomiasis	Ancylostomiasis due to Ancylostoma Duodenale
C34375	Thalassemia_Major	Thalassemia	Thalassemia Major|Beta Thalassemia|Cooley's Anemia
C34376	Hemolytic_Anemia	Normocytic_Anemia	Hemolytic Anemia	due to premature destruction of erythrocytes in the spleen or peripheral vessels; commonly associated with glucose-6-phosphate dehydrogenase deficiencies, splenomegaly, and malarial or other infections.
C34377	Acquired_Hemolytic_Anemia	Hemolytic_Anemia	Acquired Hemolytic Anemia
C34378	Autoimmune_Hemolytic_Anemia	Acquired_Hemolytic_Anemia	Autoimmune Hemolytic Anemia	due to acquired antierythrocyte autoantibodies causing premature erythrocyte clearance by the spleen; antibodies can be warm or cold active; usually slow developing and treatable.
C34379	Hereditary_Hemolytic_Anemia	Hemolytic_Anemia	Hereditary Hemolytic Anemia	includes hereditary erythrocyte membrane defects, enzyme deficiencies, hemoglobin abnormalities, stem cell defects (paroxysmal nocturnal hemoglobinuria), and alloimmune (Rh) disease of newborn.
C34380	Hypochromic_Anemia	Anemia	Hypochromic Anemia
C34381	Macrocytic_Anemia	Anemia	Macrocytic Anemia
C34382	Megaloblastic_Anemia	Macrocytic_Anemia	Megaloblastic Anemia	anemias associated with impaired DNA synthesis in bone marrow progenitor cells leading to odd shaped, macrocytic, or dysfunctional erythrocytes; usually caused by B12 or folate deficiency.
C34383	Sickle_Cell_Disease	Hemoglobinopathy	Sickle Cell Disease|Sickle Cell Anemia
C34384	Anemia_due_to_Disorder_of_Glutathione_Metabolism	Anemia	Anemia due to Disorder of Glutathione Metabolism
C34385	Anhidrosis	Symptom	Anhidrosis|Adiaphoresis
C34386	Anomia	Aphasia	Anomia|Nominal Aphasia
C34387	Anorexia_Nervosa	Anorexia|Psychiatric_Disorder	Anorexia Nervosa	syndrome in which the primary features include excessive fear of becoming overweight, body image disturbance, significant weight loss, refusal to maintain minimal normal weight, and amenorrhea; disorder occurs most frequently in adolescent females.
C34388	Anovulation	Endocrine_System_Finding	Anovulation
C34389	Anthracosilicosis	Pneumoconiosis	Anthracosilicosis
C34390	Coal_Miner_s_Pneumoconiosis	Pneumoconiosis	Coal Miner's Pneumoconiosis|Anthracosis
C34391	Aortic_Arch_Syndrome	Arterial_Occlusion|Syndrome	Aortic Arch Syndrome
C34392	Aphakia	Lens_Disorder	Aphakia
C34393	Aphasia	Nervous_System_Finding|Symptom	Aphasia	loss of ability to communicate verbally, whether by speech or reading-writing, due to organic brain dysfunction.
C34394	Broca_s_Aphasia	Aphasia	Broca's Aphasia|Motor Aphasia
C34395	Arthropod-Born_Hemorrhagic_Fever	Viral_Hemorrhagic_Fever	Arthropod-Born Hemorrhagic Fever
C34396	Arthropod-Born_Viral_Infection	Viral_Infection	Arthropod-Born Viral Infection|Arbovirus Infection
C34397	Arm_Pain	Pain	Arm Pain
C34398	Arteriosclerosis	Arterial_Disorder	Arteriosclerosis
C34399	Arteritis	Arterial_Disorder	Arteritis
C34400	Arthus_Reaction	Immediate_Hypersensitivity	Arthus Reaction|Arthus Phenomenon	development of an inflammatory lesion a few hours after intradermal injection of antigen into a sensitized animal; the lesion results from precipitation of immune complex, which causes complement activation and tissue destruction.
C34401	Aschoff_Body	Morphologic_Finding	Aschoff Body
C34402	Peritoneal_Effusion	Effusion	Peritoneal Effusion
C34403	Arteriosclerotic_Cardiovascular_Disease	Non-Neoplastic_Cardiovascular_Disorder	Arteriosclerotic Cardiovascular Disease
C34404	Aseptic_Necrosis_of_Head_and_Neck_of_Femur	Aseptic_Necrosis_of_Bone	Aseptic Necrosis of Head and Neck of Femur
C34405	Sports_Injury	Injury	Sports Injury
C34406	Avitaminosis	Vitamin_Deficiency_Disorder	Avitaminosis
C34407	Back_Injury	Injury	Back Injury
C34408	Background_Diabetic_Retinopathy	Diabetic_Retinopathy	Background Diabetic Retinopathy
C34409	Bagassosis	Extrinsic_Allergic_Alveolitis	Bagassosis
C34410	Baritosis	Pneumoconiosis	Baritosis
C34411	Cervicocranial_Syndrome	Syndrome	Cervicocranial Syndrome|Barre-Lieou Syndrome
C34412	Bartter_s_Syndrome	Syndrome	Bartter's Syndrome|Hypokalemic Alkalosis	transmitted as an autosomal recessive trait; characterized by hypertrophy and hyperplasia of the juxtaglomerular cells, and increased concentrations of renin, angiotensin II, and aldosterone in the absence of edema and hypertension.
C34413	Basilar_Artery_Syndrome	Syndrome	Basilar Artery Syndrome
C34414	Basophilia	Abnormal_Hematology_Test_Result	Basophilia
C34415	Beckwith-Wiedemann_Syndrome	Hereditary_Neoplastic_Syndrome	Beckwith-Wiedemann Syndrome
C34416	Behcet_s_Syndrome	Syndrome	Behcet's Syndrome	rare chronic inflammatory disease involving the small blood vessels; of unknown etiology and characterized by mucocutaneous ulceration in the mouth and genital region and uveitis with hypopyon; the neuroocular form may cause blindness and death; synovitis, thrombophlebitis, gastrointestinal ulcerations, retinal vasculitis, and optic atrophy may occur as well.
C34417	Benign_Neoplasm_of_Lower_Jaw_Bone	Benign_Bone_Neoplasm	Benign Neoplasm of Lower Jaw Bone
C34418	Beri_Beri	Vitamin_Deficiency_Disorder	Beri Beri
C34419	Berry_Aneurysm	Brain_Aneurysm	Berry Aneurysm|Saccular Aneurysm
C34420	Extrahepatic_Cholestasis	Gastrointestinal_System_Finding	Extrahepatic Cholestasis|Extrahepatic Bile Duct Obstruction|Extrahepatic Biliary Stasis
C34421	Biliary_Atresia	Non-Neoplastic_Biliary_Tract_Disorder	Biliary Atresia
C34422	Binocular_Vision_Disorder	Vision_Disorder	Binocular Vision Disorder
C34423	Bipolar_Disorder	Psychiatric_Disorder	Bipolar Disorder|Manic Depressive Disorder
C34424	Bipolar_Depression	Bipolar_Disorder|Depression	Bipolar Depression	severe disorder characterized by one or more manic episodes; although diagnosis does not require a major depressive episode, virtually all cases eventually develop one.
C34425	Bird_Fancier_s_Lung	Extrinsic_Allergic_Alveolitis	Bird Fancier's Lung|Avian Hypersensitivity Pneumonitis
C34426	Blackwater_Fever	Malaria	Blackwater Fever|Malarial Hemoglobinuria
C34427	Blast_Injury	Injury	Blast Injury
C34428	Blastomycosis	Fungal_Infection	Blastomycosis
C34429	North_American_Blastomycosis	Blastomycosis	North American Blastomycosis|Blastomyces Dermatitidis Infection
C34430	Blepharoconjunctivitis	Non-Neoplastic_Eye_Disorder	Blepharoconjunctivitis
C34431	Blind_Loop_Syndrome	Malabsorption_Syndrome	Blind Loop Syndrome|Stasis (Blind Loop) Syndrome|Stasis Syndrome
C34432	Bone_Development_Disorder	Non-Neoplastic_Bone_Disorder	Bone Development Disorder
C34433	Bone_Marrow_Disorder	Hematopoietic_System_Disorder	Bone Marrow Disorder|Bone Marrow Disease
C34434	Bonnevie-Ullrich_Syndrome	Syndrome	Bonnevie-Ullrich Syndrome
C34435	Chronic_Encephalopathy	Encephalopathy	Chronic Encephalopathy|Chronic Brain Damage	brain damage which has persisted over a long period of time.
C34436	Retinal_Arterial_Branch_Occlusion	Retinal_Artery_Occlusion	Retinal Arterial Branch Occlusion
C34437	Breast_Swelling	Reproductive_System_Finding	Breast Swelling
C34438	Breech_Presentation	Pregnancy_Complication	Breech Presentation
C34439	Bronchospasm	Non-Neoplastic_Lung_Disorder	Bronchospasm
C34440	Bulimia	Psychiatric_Disorder	Bulimia|Bulimia Nervosa
C34441	Burn	Injury	Burn
C34442	Chemical_Burn	Burn	Chemical Burn
C34443	Gallbladder_Stone	Gastrointestinal_System_Finding|Stone	Gallbladder Stone|Gallbladder Calculus
C34444	Chronic_Mucocutaneous_Candidiasis	Chronic_Candidiasis|Mucocutaneous_Candidiasis	Chronic Mucocutaneous Candidiasis
C34445	Cannabis_Dependence	Drug_Dependence	Cannabis Dependence
C34446	Capgras_Syndrome	Syndrome	Capgras Syndrome
C34447	Head_and_Neck_Squamous_Cell_Carcinoma	Head_and_Neck_Carcinoma|Squamous_Cell_Carcinoma	Head and Neck Squamous Cell Carcinoma|Squamous Cell Carcinoma of Head and Neck|Squamous Cell Carcinoma of the Head and Neck
C34448	Carcinosarcoma	Malignant_Mixed_Neoplasm	Carcinosarcoma|carcinosarcoma	A malignant tumor composed of a mixture of carcinomatous and sarcomatous elements.
C34449	Hypertrophic_Cardiomyopathy	Cardiomyopathy	Hypertrophic Cardiomyopathy
C34450	Carpal_Tunnel_Syndrome	Syndrome	Carpal Tunnel Syndrome
C34451	Car_Sickness	Motion_Sickness	Car Sickness
C34452	Catalepsy	Nervous_System_Finding	Catalepsy	diminished responsiveness characterized by trancelike states and by rigidity of muscles; patient tends to remain in any position in which he is placed.
C34453	Cauda_Equina_Syndrome_with_Neurogenic_Bladder	Cauda_Equina_Syndrome	Cauda Equina Syndrome with Neurogenic Bladder
C34454	Cellulitis_of_Hand	Cellulitis	Cellulitis of Hand
C34455	Central_Opacity_of_Cornea	Eye_and_Ear_Finding	Central Opacity of Cornea
C34456	Central_Retinal_Artery_Occlusion	Retinal_Artery_Occlusion	Central Retinal Artery Occlusion
C34457	Cutaneous_Schistosomiasis	Schistosomiasis|Skin_Infection	Cutaneous Schistosomiasis
C34458	Intracranial_Aneurysm	Aneurysm	Intracranial Aneurysm
C34459	Cerebral_Atherosclerosis	Atherosclerosis	Cerebral Atherosclerosis
C34460	Cerebral_Palsy	Neurodegenerative_Disorder	Cerebral Palsy
C34461	Cerebrospinal_Fluid_Otorrhea	Otorrhea	Cerebrospinal Fluid Otorrhea
C34462	Cardiomyopathy_in_Chagas_Disease	Cardiomyopathy	Cardiomyopathy in Chagas' Disease|Cardiovascular Trypanosomiasis
C34463	Chlamydial_Infection	Infectious_Disorder	Chlamydial Infection
C34464	Chronic_Non-Suppurative_Destructive_Cholangitis	Retired_Concepts	Chronic Non-Suppurative Destructive Cholangitis
C34465	Cholecystitis	Gallbladder_Disorder	Cholecystitis
C34466	Cartilage_Development_Disorder	Non-Neoplastic_Bone_Disorder	Cartilage Development Disorder
C34467	Synovial_Chondromatosis	Benign_Synovial_Neoplasm|Chondromatosis	Synovial Chondromatosis|Henderson-Jones Syndrome|Reichel's Syndrome
C34468	Choroid_Disorder	Uveal_Disorder	Choroid Disorder|Choroid Disease
C34469	Choroideremia	Non-Neoplastic_Eye_Disorder	Choroideremia|Progressive Choroidal Atrophy
C34470	Chromosome_Disorder	Genetic_Disorder	Chromosome Disorder|Chromosome Abnormality Disorder	clinical conditions caused by an abnormal chromosome constitution in which there is extra or missing chromosome material, either a whole chromosome or a chromosome segment.
C34471	Chronic_Eosinophilic_Pneumonia	Eosinophilic_Pneumonia	Chronic Eosinophilic Pneumonia
C34472	Chronic_Ethmoidal_Sinusitis	Chronic_Sinusitis|Ethmoidal_Sinusitis	Chronic Ethmoidal Sinusitis
C34473	Chronic_Frontal_Sinusitis	Chronic_Sinusitis|Frontal_Sinusitis	Chronic Frontal Sinusitis
C34474	Chronic_Gingivitis	Gingivitis	Chronic Gingivitis
C34475	Chronic_Glomerulonephritis_with_Lesion_of_Membranous_Glomerulonephritis	Chronic_Glomerulonephritis	Chronic Glomerulonephritis with Lesion of Membranous Glomerulonephritis
C34476	Chronic_Iridocyclitis	Iridocyclitis	Chronic Iridocyclitis
C34477	Chronic_Maxillary_Sinusitis	Chronic_Sinusitis|Maxillary_Sinusitis	Chronic Maxillary Sinusitis
C34478	Chronic_Pulmonary_Heart_Disease	Non-Neoplastic_Heart_Disorder	Chronic Pulmonary Heart Disease|Cor Pulmonale
C34479	Chronic_Rhinitis	Rhinitis	Chronic Rhinitis
C34480	Chronic_Sphenoidal_Sinusitis	Chronic_Sinusitis|Sphenoidal_Sinusitis	Chronic Sphenoidal Sinusitis
C34481	Churg-Strauss_Syndrome	Syndrome	Churg-Strauss Syndrome|Allergic Granulomatous Angiitis
C34482	Chylous_Ascites	Ascites	Chylous Ascites
C34483	Scar	Fibrosis	Scar
C34484	Clonus	Neurological_Signs_and_Symptoms	Clonus
C34485	Closed_Dislocation_of_Hip	Hip_Dislocation	Closed Dislocation of Hip
C34486	Closed_Dislocation_of_Shoulder	Shoulder_Dislocation	Closed Dislocation of Shoulder
C34487	Closed_Dislocation_Multiple_and_Ill-Defined_Sites	Closed_Dislocation	Closed Dislocation, Multiple and Ill-Defined Sites
C34488	Closed_Fracture_of_Carpal_Bone	Carpal_Bone_Fracture|Closed_Fracture	Closed Fracture of Carpal Bone
C34489	Closed_Fracture_of_Malar_and_Maxillary_Bone	Closed_Fracture	Closed Fracture of Malar and Maxillary Bone
C34490	Closed_Fracture_of_Mandible	Closed_Fracture|Mandible_Fracture	Closed Fracture of Mandible
C34491	Clubbing_of_Fingers	Congenital_or_Acquired_Anatomic_Abnormality	Clubbing of Fingers
C34492	Cocaine_Dependence	Drug_Dependence	Cocaine Dependence|Cocaine Addiction
C34493	Coccidiosis	Protozoal_Infection	Coccidiosis
C34494	Colic	Abdominal_Pain	Colic
C34495	Closed_Colles_Fracture	Closed_Fracture|Colles_Fracture	Closed Colles' Fracture
C34496	Defective_Color_Vision	Eye_and_Ear_Finding	Defective Color Vision
C34497	Coma	Nervous_System_Finding	Coma
C34498	Combat_Neurosis	Neurosis	Combat Neurosis
C34499	Common_Bile_Duct_Stone	Bile_Duct_Stone	Common Bile Duct Stone
C34500	Acute_Nasopharyngitis	Nasopharyngitis	Acute Nasopharyngitis|Common Cold
C34501	Communicating_Hydrocephalus	Hydrocephalus	Communicating Hydrocephalus
C34502	Congenital_Spondylolysis_Lumbosacral_Region	Congenital_Spondylolysis	Congenital Spondylolysis, Lumbosacral Region
C34503	Xerophthalmia	Non-Neoplastic_Conjunctival_Disorder	Xerophthalmia|Conjunctival Xerosis
C34504	Conjunctivitis	Non-Neoplastic_Conjunctival_Disorder	Conjunctivitis	Conjunctivitis; inflammation of the conjunctiva of the eye.
C34505	Acute_Hemorrhagic_Conjunctivitis	Acute_Conjunctivitis	Acute Hemorrhagic Conjunctivitis
C34506	Atopic_Conjunctivitis	Conjunctivitis	Atopic Conjunctivitis|Allergic Conjunctivitis
C34507	Giant_Papillary_Conjunctivitis	Papillary_Conjunctivitis	Giant Papillary Conjunctivitis
C34508	Vernal_Conjunctivitis	Chronic_Conjunctivitis	Vernal Conjunctivitis
C34509	Viral_Conjunctivitis	Conjunctivitis|Infectious_Disorder_by_Site	Viral Conjunctivitis
C34510	Conn_s_Syndrome	Endocrine_Syndrome	Conn's Syndrome|Primary Hyperaldosteronism
C34511	Coprophagia	Symptom	Coprophagia
C34512	Hereditary_Corneal_Dystrophy	Corneal_Dystrophy	Hereditary Corneal Dystrophy
C34513	Corneal_Dystrophy	Non-Neoplastic_Corneal_Disorder	Corneal Dystrophy
C34514	Corn	Non-Neoplastic_Skin_Disorder	Corn
C34515	Coronary_Vasospasm	Vasospasm	Coronary Vasospasm
C34516	Corpus_Luteum_Cyst	Benign_Ovarian_Cyst	Corpus Luteum Cyst
C34517	Limb_Cramp	Muscle_Cramp	Limb Cramp
C34518	Cri_du_Chat_Syndrome	Syndrome	Cri du Chat Syndrome|5p Deletion Syndrome|Cat-Cry Syndrome
C34519	Cystic_Endometrial_Hyperplasia	Endometrial_Hyperplasia	Cystic Endometrial Hyperplasia
C34520	Cysticercosis	Parasitic_Infection	Cysticercosis
C34521	Dacryocystitis	Lacrimal_System_Disorder	Dacryocystitis
C34522	Multi-infarct_Dementia	Vascular_Dementia	Multi-infarct Dementia|Multi Infarct Dementia	dementia, due to significant cerebrovascular disease, with a stepwise deteriorating course and a 'patchy' distribution of neurologic deficits.
C34523	Pre-senile_Dementia	Dementia	Pre-senile Dementia|Presenile Dementia
C34524	Senile_Dementia	Dementia	Senile Dementia
C34525	Vascular_Dementia	Dementia	Vascular Dementia
C34526	Demyelinating_Disorder_of_Central_Nervous_System	Demyelinating_Disorder	Demyelinating Disorder of Central Nervous System|Demyelinating Disease of Central Nervous System
C34527	Demyelinating_Disorder	Neurodegenerative_Disorder	Demyelinating Disorder|Demyelinating Disease
C34528	Dengue_Fever	Viral_Infection	Dengue Fever
C34529	Enamel_Hypoplasia	Non-Neoplastic_Dental_Disorder	Enamel Hypoplasia
C34530	Dental_Pulp_Disorder	Dental_Disorder	Dental Pulp Disorder
C34531	Amyloid_Deposition	Immunoglobulin_Deposition	Amyloid Deposition
C34532	Endogenous_Depression	Depression	Endogenous Depression	pervasive depression that adversely affects one's daily life; mental processes are slowed, thoughts are distorted by self-disgust and despair, concentration is difficult, and suicidal thoughts may intrude.
C34533	Reactive_Depression	Depression	Reactive Depression
C34534	Dermatitis_due_to_Food_taken_Internally	Dermatitis	Dermatitis due to Food taken Internally
C34535	Dermatophytosis_of_Groin_and_Perianal_Area	Dermatophytosis	Dermatophytosis of Groin and Perianal Area
C34536	Dermatophytosis_of_Scalp_and_Beard	Dermatophytosis	Dermatophytosis of Scalp and Beard
C34537	Lipoatrophic_Diabetes_Mellitus	Diabetes_Mellitus	Lipoatrophic Diabetes Mellitus
C34538	Diabetic_Retinopathy	Non-Neoplastic_Retinal_Disorder|Retinal_Vascular_Disorder	Diabetic Retinopathy
C34539	Digitalis_Toxicity	Drug_Toxicity	Digitalis Toxicity
C34540	Dipetalonemiasis	Parasitic_Infection	Dipetalonemiasis
C34541	Diphtheria	Bacterial_Infection	Diphtheria
C34542	Anterior_Nasal_Diphtheria	Diphtheria	Anterior Nasal Diphtheria
C34543	Pseudomembranous_Diphtheritic_Conjunctivitis	Infectious_Disorder_by_Site|Pseudomembranous_Conjunctivitis	Pseudomembranous Diphtheritic Conjunctivitis
C34544	Cutaneous_Diphtheria	Skin_Infection	Cutaneous Diphtheria
C34545	Faucial_Diphtheria	Head_and_Neck_Infection	Faucial Diphtheria
C34546	Laryngeal_Diphtheria	Head_and_Neck_Infection	Laryngeal Diphtheria
C34547	Nasopharyngeal_Diphtheria	Head_and_Neck_Infection	Nasopharyngeal Diphtheria
C34548	Fluid_Discharge	Symptom	Fluid Discharge|Discharge	Discharge; the pouring forth of a fluid.
C34549	Disturbance_of_Skin_Sensation	Sensory_Manifestations	Disturbance of Skin Sensation
C34550	Colonic_Diverticulum	Diverticulum	Colonic Diverticulum|Colon Diverticulum
C34551	Colonic_Diverticulosis	Diverticulosis	Colonic Diverticulosis
C34553	Dry_Eye_Syndrome	Non-Neoplastic_Eye_Disorder	Dry Eye Syndrome
C34554	Dwarfism	Endocrine_System_Finding	Dwarfism
C34555	Pituitary_Dwarfism	Dwarfism	Pituitary Dwarfism
C34556	Dyschondroplasia	Non-Neoplastic_Bone_Disorder	Dyschondroplasia
C34557	Skin_Pigmentation_Disorder	Non-Neoplastic_Skin_Disorder	Skin Pigmentation Disorder
C34558	Amebic_Colitis	Colitis	Amebic Colitis
C34559	Dysmenorrhea	Menstrual_Disorder	Dysmenorrhea
C34560	Dysostosis	Non-Neoplastic_Bone_Disorder	Dysostosis
C34561	Dyspnea_Paroxysmal_Nocturnal	Dyspnea	Dyspnea Paroxysmal Nocturnal|Cardiac Asthma
C34562	Dysthymic_Disorder	Psychiatric_Disorder	Dysthymic Disorder
C34563	Dystonia	Non-Neoplastic_Soft_Tissue_Disorder	Dystonia	syndrome dominated by involuntary, sustained or spasmodic, patterned, and repetitive muscle contractions; frequently causing twisting, flexing or extending, and squeezing movements or abnormal postures.
C34564	Idiopathic_Torsion_Dystonia	Dystonia	Idiopathic Torsion Dystonia
C34565	Vulvar_Dystrophy	Vulvar_Non-Neoplastic_Disorder	Vulvar Dystrophy
C34566	Congenital_Ectopic_Lens	Congenital_Lens_Disorder	Congenital Ectopic Lens
C34567	Ectromelia	Congenital_Abnormality	Ectromelia
C34568	Ehlers-Danlos_Syndrome	Syndrome	Ehlers-Danlos Syndrome
C34569	Elephantiasis	Swelling	Elephantiasis
C34570	Emaciation	Metabolic_Disorder	Emaciation
C34571	Interstitial_Emphysema	Emphysema	Interstitial Emphysema
C34572	Empyema	Bacterial_Infection	Empyema
C34573	Empyema_with_Fistula	Empyema	Empyema with Fistula
C34574	Pulmonary_Empyema	Empyema	Pulmonary Empyema
C34575	Tuberculous_Empyema	Empyema|Tuberculosis	Tuberculous Empyema
C34576	Epidemic_Encephalitis	Viral_Encephalitis	Epidemic Encephalitis
C34577	Japanese_B_Encephalitis	Mosquito-Born_Viral_Encephalitis	Japanese B Encephalitis
C34578	Acute_Disseminated_Encephalomyelitis	Encephalomyelitis	Acute Disseminated Encephalomyelitis
C34579	Tick-born_Viral_Encephalitis	Viral_Encephalitis	Tick-born Viral Encephalitis
C34580	Encephalomyelitis	Central_Nervous_System_Infectious_Disorder	Encephalomyelitis
C34581	Endarteritis	Arteritis	Endarteritis
C34582	Endocarditis	Non-Neoplastic_Heart_Disorder	Endocarditis
C34583	Subacute_Bacterial_Endocarditis	Endocarditis	Subacute Bacterial Endocarditis
C34584	Endocervical_Polyp	Benign_Cervical_Neoplasm|Cervical_Glandular_Neoplasm|Cervical_Polyp|Neoplastic_Polyp	Endocervical Polyp
C34585	Endomyocardial_Fibrosis	Non-Neoplastic_Heart_Disorder	Endomyocardial Fibrosis
C34586	Endophthalmitis	Eye_Infection	Endophthalmitis
C34587	Parasitic_Endophthalmitis	Endophthalmitis|Parasitic_Infection	Parasitic Endophthalmitis
C34588	Enuresis	Genitourinary_Signs_and_Symptoms	Enuresis
C34589	Epicondylitis	Non-Neoplastic_Soft_Tissue_Disorder	Epicondylitis
C34590	Epidemic_Keratoconjunctivitis	Keratoconjunctivitis	Epidemic Keratoconjunctivitis
C34591	Erythematosquamous_Dermatosis	Dermatosis	Erythematosquamous Dermatosis
C34592	Erythroid_Hyperplasia	Abnormal_Bone_Marrow_Test_Result	Erythroid Hyperplasia
C34593	Erythromelalgia	Symptom	Erythromelalgia
C34594	Escherichia_Coli_Infection	Bacterial_Infection	Escherichia Coli Infection|E Coli Infection
C34595	Esophageal_Stricture	Esophageal_Disorder	Esophageal Stricture
C34596	Internal_Strabismus	Strabismus	Internal Strabismus
C34597	Ethmoidal_Sinusitis	Sinusitis	Ethmoidal Sinusitis
C34598	Euphoria	Symptom	Euphoria
C34599	Excoriation	Injury|Integumentary_System_Signs_and_Symptoms	Excoriation
C34600	Exercise-Induced_Bronchospasm	Bronchospasm	Exercise-Induced Bronchospasm
C34601	Divergent_Strabismus	Strabismus	Divergent Strabismus
C34602	Ocular_Injury	Eye_and_Ear_Finding|Injury	Ocular Injury
C34603	Face_Injury	Head_Injury	Face Injury
C34605	Farmer_s_Lung	Pneumonia	Farmer's Lung
C34606	Fasciculation	Nervous_System_Finding	Fasciculation
C34607	Favism	Non-Autoimmune_Hemolytic_Anemia	Favism
C34608	Fever_of_Unknown_Origin	Fever	Fever of Unknown Origin
C34609	Fibrous_Dysplasia_of_Bone	Non-Neoplastic_Bone_Disorder	Fibrous Dysplasia of Bone
C34610	Polyostotic_Fibrous_Dysplasia_of_Bone	Fibrous_Dysplasia_of_Bone	Polyostotic Fibrous Dysplasia of Bone
C34611	Filariasis	Parasitic_Infection	Filariasis
C34612	Mansonella_Ozzardi_Infection	Filariasis	Mansonella Ozzardi Infection
C34613	Finger_Injury	Hand_Injury	Finger Injury
C34614	Intestinal_Fistula_excluding_Rectum_and_Anus	Intestinal_Fistula	Intestinal Fistula excluding Rectum and Anus
C34615	Flank_Pain	Pain	Flank Pain
C34616	Flat_Foot	Congenital_or_Acquired_Anatomic_Abnormality	Flat Foot|Fallen Arch
C34617	Follicular_Cyst_of_Ovary	Benign_Ovarian_Cyst	Follicular Cyst of Ovary
C34618	Foot_Pain	Pain	Foot Pain
C34619	Patent_Foramen_Ovale	Congenital_Cardiovascular_Disorder	Patent Foramen Ovale
C34620	Foreign_Body	Other_Finding	Foreign Body
C34621	Foreign_Body_Granuloma_of_Muscle	Foreign_Body_Granuloma	Foreign Body Granuloma of Muscle
C34622	Foreign_Body_in_Gastrointestinal_Tract	Foreign_Body|Gastrointestinal_System_Finding	Foreign Body in Gastrointestinal Tract
C34623	Closed_Fracture	Fracture	Closed Fracture
C34624	Open_Fracture	Fracture	Open Fracture|Compound Fracture
C34625	Frohlich_s_Syndrome	Syndrome	Frohlich's Syndrome
C34626	Frontal_Sinusitis	Sinusitis	Frontal Sinusitis
C34627	Frostbite	Injury	Frostbite
C34628	Nonorganic_Enuresis	Enuresis	Nonorganic Enuresis
C34629	Furunculosis	Skin_Infection	Furunculosis
C34630	Gagging	Gastrointestinal_System_Signs_and_Symptoms	Gagging
C34631	Gallbladder_Disorder	Biliary_Tract_Disorder	Gallbladder Disorder|Gallbladder Disease
C34632	Gastroenteritis	Gastrointestinal_Infection	Gastroenteritis
C34633	Gastrointestinal_Malfunction_Arising_from_Mental_Factor	Psychosomatic_Disorder	Gastrointestinal Malfunction Arising from Mental Factor
C34634	Congenital_Leucocyte_Anomaly	Genetic_Disorder|Non-Neoplastic_Hematologic_Disorder	Congenital Leucocyte Anomaly|Genetic Anomaly of Leucocyte
C34635	Gingival_Pocket	Head_and_Neck_Finding	Gingival Pocket
C34636	Gingivitis	Non-Neoplastic_Oral_Cavity_Disorder	Gingivitis	Gingivitis is a disorder involving inflammation of the gums (gingiva). (Medline Plus Medical Dictionary)
C34637	Necrotizing_Ulcerative_Gingivitis	Gingivitis	Necrotizing Ulcerative Gingivitis|Vincent's Angina
C34638	Glanders	Bacterial_Infection	Glanders
C34639	Angle_Closure_Glaucoma	Glaucoma	Angle Closure Glaucoma
C34640	Primary_Angle_Closure_Glaucoma	Angle_Closure_Glaucoma	Primary Angle Closure Glaucoma
C34641	Open_Angle_Glaucoma	Glaucoma	Open Angle Glaucoma
C34642	Globus_Hystericus	Hysteria	Globus Hystericus
C34643	IgA_Nephropathy	Glomerulonephritis	IgA Nephropathy	most common cause of primary glomerular disease in Europe, Australia, and United States; lesions formed as a consequence of mesangial formations of immune deposits composed of IgA.
C34644	Membranoproliferative_Glomerulonephritis	Glomerulonephritis	Membranoproliferative Glomerulonephritis
C34645	Membranous_Glomerulonephritis	Glomerulonephritis	Membranous Glomerulonephritis	characterized histologically by proteinaceous deposits on the glomerular capillary basement membrane or by thickening of the membrane; clinically similar to chronic glomerulonephritis, occasionally with transient nephrotic syndrome.
C34646	Glucose_Intolerance	Non-Neoplastic_Endocrine_Disorder	Glucose Intolerance
C34647	Non-toxic_Nodular_Goiter	Nontoxic_Goiter	Non-Toxic Nodular Goiter
C34648	Acute_Gonococcal_Infection_of_Lower_Genitourinary_Tract	Gonococcal_Infection_of_Genitourinary_Tract	Acute Gonococcal Infection of Lower Genitourinary Tract
C34649	Goodpasture_Syndrome	Syndrome	Goodpasture Syndrome|Lung Purpura with Glomerulonephritis
C34650	Gout	Arthritis|Metabolic_Disorder	Gout
C34651	Granular_Corneal_Dystrophy	Corneal_Dystrophy|Genetic_Disorder	Granular Corneal Dystrophy
C34652	Granulation_Tissue	Abnormal_Tissue_Present	Granulation Tissue
C34653	Granulomatous_Arteritis	Vasculitis	Granulomatous Arteritis
C34654	Hemophilus_Infection	Bacterial_Infection	Hemophilus Infection
C34655	Hemophilus_Influenza_Infection	Hemophilus_Infection	Hemophilus Influenza Infection
C34656	Hair_Disorder	Skin_Disorder	Hair Disorder
C34657	Hallucinogen_Dependence	Drug_Dependence	Hallucinogen Dependence
C34658	Hallux_Valgus	Congenital_or_Acquired_Anatomic_Abnormality	Hallux Valgus
C34659	Hand_Injury	Limb_Injury	Hand Injury
C34660	Head_Injury	Head_and_Neck_Finding|Injury	Head Injury
C34661	Headache	Neurological_Signs_and_Symptoms	Headache	Pain in various parts of the head, not confined to the area of distribution of any nerve.
C34662	Central_Hearing_Loss	Hearing_Loss	Central Hearing Loss
C34663	High_Frequency_Hearing_Loss	Hearing_Loss	High Frequency Hearing Loss
C34664	Noise_Induced_Hearing_Loss	Hearing_Loss	Noise Induced Hearing Loss
C34665	Heart_Block	Arrhythmia	Heart Block
C34666	Heart_Malformation	Congenital_Cardiovascular_Disorder	Heart Malformation
C34668	Cardiac_Rupture	Rupture	Cardiac Rupture|Myocardial Rupture
C34669	Post_Infarct_Cardiac_Rupture	Cardiac_Rupture	Post Infarct Cardiac Rupture
C34670	Heartburn	Pain	Heartburn
C34671	Heberden_s_Node	Exostosis	Heberden's Node|Tuberculum Arthriticum
C34672	Heinz_Body	Morphologic_Finding	Heinz Body
C34674	Hemimelia	Ectromelia	Hemimelia
C34675	Hemoglobin_C_Disease	Hemoglobinopathy	Hemoglobin C Disease
C34676	Hemoglobin_SC_Disease	Hemoglobinopathy	Hemoglobin SC Disease
C34677	Hemoglobinuria	Abnormal_Urine_Test_Result	Hemoglobinuria
C34678	Hemoglobinuria_due_to_Hemolysis_from_External_Causes	Hemoglobinuria	Hemoglobinuria due to Hemolysis from External Causes
C34679	Hemoperitoneum	Hemorrhage	Hemoperitoneum
C34680	Non-Traumatic_Hemoperitoneum	Hemoperitoneum	Non-Traumatic Hemoperitoneum
C34681	Hemorrhage_of_Rectum_and_Anus	Gastrointestinal_Hemorrhage	Hemorrhage of Rectum and Anus
C34682	Congo-Crimean_Hemorrhagic_Fever	Viral_Hemorrhagic_Fever	Congo-Crimean Hemorrhagic Fever
C34683	Dengue_Hemorrhagic_Fever	Dengue_Fever	Dengue Hemorrhagic Fever
C34684	Alcoholic_Hepatitis	Alcoholic_Liver_Disease|Hepatitis	Alcoholic Hepatitis
C34685	Hernia	Congenital_or_Acquired_Anatomic_Abnormality	Hernia
C34686	Hernia_without_mention_of_Obstruction_or_Gangrene	Hernia	Hernia without mention of Obstruction or Gangrene
C34687	Diaphragmatic_Hernia	Hernia	Diaphragmatic Hernia
C34688	Traumatic_Diaphragmatic_Hernia	Diaphragmatic_Hernia	Traumatic Diaphragmatic Hernia
C34689	Femoral_Hernia	Hernia	Femoral Hernia
C34690	Inguinal_Hernia	Hernia	Inguinal Hernia
C34691	Direct_Inguinal_Hernia	Inguinal_Hernia	Direct Inguinal Hernia
C34692	Indirect_Inguinal_Hernia	Inguinal_Hernia	Indirect Inguinal Hernia
C34693	Scrotal_Hernia	Hernia	Scrotal Hernia
C34694	Heroin_Dependence	Drug_Dependence	Heroin Dependence|Heroin Addiction
C34695	Cold_Sore	Viral_Infection	Cold Sore
C34696	Herpes_Zoster_Dermatitis_of_Eyelid	Herpes_Zoster_Dermatitis	Herpes Zoster Dermatitis of Eyelid
C34697	Herpetic_Vulvovaginitis	Genitourinary_System_Infection|Viral_Infection|Vulvovaginitis	Herpetic Vulvovaginitis
C34698	Hip_Dislocation	Joint_Dislocation	Hip Dislocation
C34699	Hip_Pain	Bone_Pain	Hip Pain|Coxalgia
C34700	Aganglionic_Megacolon	Megacolon	Aganglionic Megacolon|Hirschsprung's Disease
C34702	Hookworm_Infection	Parasitic_Infection	Hookworm Infection
C34703	Hyperalgesia	Symptom	Hyperalgesia	excessive sensitivity to painful stimuli.
C34704	Type_II_Hyperlipidemia	Hyperlipidemia	Type II Hyperlipidemia
C34705	Hypergammaglobulinemia	Abnormal_Blood_and_Hematology_Test_Result	Hypergammaglobulinemia
C34706	Hyperactivity	Symptom	Hyperactivity
C34707	Hyperlipidemia	Abnormal_Blood_and_Hematology_Test_Result	Hyperlipidemia
C34708	Type_IIb_Hyperlipoproteinemia	Hyperlipoproteinemia	Type IIb Hyperlipoproteinemia
C34709	Hyperlipoproteinemia	Abnormal_Blood_and_Hematology_Test_Result	Hyperlipoproteinemia
C34710	Remnant_Hyperlipidemia	Hyperlipidemia	Remnant Hyperlipidemia
C34711	Fredrickson_Type_IV_Lipidemia	Hyperlipidemia	Fredrickson Type IV Lipidemia
C34712	Hyperostosis	Non-Neoplastic_Bone_Disorder	Hyperostosis|Bone Hypertrophy
C34713	Hyperostosis_of_Skull	Hyperostosis	Hyperostosis of Skull
C34714	Hypersplenism	Hematopoietic_System_Finding	Hypersplenism
C34715	Hypertelorism	Congenital_Abnormality	Hypertelorism|Hypertelorism of Orbit
C34716	Hypertropia	Eye_and_Ear_Finding	Hypertropia
C34717	Hypogalactia	Endocrine_System_Signs_and_Symptoms	Hypogalactia
C34718	Hypohidrosis	Symptom	Hypohidrosis
C34719	Hypomenorrhea	Menstrual_Disorder	Hypomenorrhea
C34720	Hypotrichosis	Non-Neoplastic_Hair_Disorder	Hypotrichosis
C34721	Hysteria	Symptom	Hysteria
C34722	Illusion	Sensory_Manifestations	Illusion	An illusion is a misperception of a real external stimulus. (from Wikipedia)
C34723	Impulse-Control_Disorder	Socialized_Conduct_Disorder	Impulse-Control Disorder
C34724	Low_Birth_Weight	Pregnancy_Complication	Low Birth Weight	an infant weighing 5-1/2 pounds or less at birth.
C34725	Premature_Infant	Pregnancy_Complication	Premature Infant
C34726	Infectious_Mononucleosis	Benign_Lymphoproliferative_Disorder|Epstein-Barr_Virus_Infection	Infectious Mononucleosis
C34727	Infective_Otitis_Externa	External_Ear_Infection	Infective Otitis Externa
C34728	Inguinal_Hernia_without_mention_of_Obstruction_or_Gangrene	Hernia_without_mention_of_Obstruction_or_Gangrene|Inguinal_Hernia	Inguinal Hernia without mention of Obstruction or Gangrene
C34729	Injury_to_Diaphragm_without_mention_of_Open_Wound_into_Cavity	Injury_to_Diaphragm	Injury to Diaphragm without mention of Open Wound into Cavity
C34730	Insulin_Coma	Coma	Insulin Coma
C34731	Intestinal_Disaccharidase_Deficiency_and_Disaccharidase_Malabsorption	Malabsorption_Syndrome	Intestinal Disaccharidase Deficiency and Disaccharidase Malabsorption
C34732	Intestinal_Fistula	Fistula	Intestinal Fistula
C34733	Intestinal_Pseudo-obstruction	Intestinal_Disorder	Intestinal Pseudo-obstruction
C34734	Intracranial_Abscess	Abscess	Intracranial Abscess
C34735	Intraoperative_Complication	Complication	Intraoperative Complication
C34736	Iridocyclitis	Non-Neoplastic_Eye_Disorder	Iridocyclitis
C34737	Iris_Disorder	Uveal_Disorder	Iris Disorder
C34738	Ischemia	Cardiovascular_System_Finding	Ischemia
C34739	Jacksonian_Seizure	Seizure	Jacksonian Seizure
C34740	Cholestatic_Jaundice	Retired_Concepts	Cholestatic Jaundice
C34741	Dubin-Johnson_Syndrome	Syndrome	Dubin-Johnson Syndrome
C34742	Obstructive_Jaundice	Jaundice	Obstructive Jaundice|Cholestatic Jaundice
C34743	Dendritic_Keratitis	Keratitis	Dendritic Keratitis
C34744	Keratoconjunctivitis	Non-Neoplastic_Eye_Disorder	Keratoconjunctivitis
C34745	Keratoderma	Non-Neoplastic_Skin_Disorder	Keratoderma
C34746	Acquired_Keratoderma	Keratoderma	Acquired Keratoderma
C34747	Keratosis	Non-Neoplastic_Skin_Disorder	Keratosis
C34748	Palmoplantar_Keratoderma	Keratoderma	Palmoplantar Keratoderma
C34749	Acute_Renal_Failure_with_Tubular_Necrosis	Acute_Renal_Failure	Acute Renal Failure with Tubular Necrosis
C34750	Cystic_Kidney_Disease	Non-Neoplastic_Renal_Disorder	Cystic Kidney Disease|Polycystic Kidney
C34751	Medullary_Sponge_Kidney	Cystic_Kidney_Disease	Medullary Sponge Kidney
C34752	Klinefelter_s_Syndrome	Endocrine_Syndrome	Klinefelter's Syndrome|Hypogonadotropic Hypogonadism|XXY Syndrome	genetic disease that produces sterile males with small testes lacking sperm due to XXY karyotype.
C34753	Knee_Injury	Leg_Injury	Knee Injury
C34754	Kyphosis	Non-Neoplastic_Bone_Disorder	Kyphosis
C34755	Acquired_Kyphosis	Kyphosis	Acquired Kyphosis
C34756	Acquired_Postural_Kyphosis	Acquired_Kyphosis	Acquired Postural Kyphosis
C34757	Lacrimal_Duct_Obstruction	Obstruction	Lacrimal Duct Obstruction
C34758	Visceral_Larva_Migrans	Parasitic_Infection	Visceral Larva Migrans
C34759	Latent_Schizophrenia	Schizophrenia	Latent Schizophrenia
C34760	Laurence-Moon_Syndrome	Genetic_Disorder|Syndrome	Laurence-Moon Syndrome
C34761	Lead_Poisoning	Poisoning	Lead Poisoning
C34762	Leg_Cramp	Limb_Cramp	Leg Cramp
C34763	Leg_Injury	Limb_Injury	Leg Injury
C34764	Leg_Pain	Pain	Leg Pain
C34765	Lower_Extremity_Ulcer	Ulcer	Lower Extremity Ulcer
C34766	Perthes_Disease	Bone_Necrosis	Perthes Disease
C34767	Leishmaniasis	Parasitic_Infection	Leishmaniasis
C34768	Cutaneous_Leishmaniasis	Leishmaniasis|Skin_Infection	Cutaneous Leishmaniasis
C34769	American_Cutaneous_Leishmaniasis	Cutaneous_Leishmaniasis	American Cutaneous Leishmaniasis
C34770	Asian_Desert_Cutaneous_Leishmaniasis	Cutaneous_Leishmaniasis	Asian Desert Cutaneous Leishmaniasis
C34771	Kala-Azar	Leishmaniasis	Kala-Azar|Visceral Leishmaniasis
C34772	Lens_Subluxation	Lens_Disorder	Lens Subluxation
C34773	Leriche_Syndrome	Arterial_Occlusion|Syndrome	Leriche Syndrome
C34774	Chronic_Monocytic_Leukemia	Hematopoietic_and_Lymphoid_Neoplasms_Antiquated	Chronic Monocytic Leukemia
C34775	Leukorrhea	Genitourinary_Signs_and_Symptoms	Leukorrhea
C34776	Lice	Insect	Lice
C34777	Atrophic_Lichen_Planus	Lichen_Planus	Atrophic Lichen Planus
C34778	Bullous_Lichen_Planus	Lichen_Planus	Bullous Lichen Planus
C34779	Hypertrophic_Lichen_Planus	Lichen_Planus	Hypertrophic Lichen Planus
C34780	Lichenoid_Drug_Eruption	Dermatitis	Lichenoid Drug Eruption
C34781	Spastic_Diplegia	Cerebral_Palsy	Spastic Diplegia
C34782	Alcoholic_Cirrhosis	Alcoholic_Liver_Disease|Cirrhosis	Alcoholic Cirrhosis
C34783	Alcoholic_Liver_Disease	Hepatocellular_Damage	Alcoholic Liver Disease
C34784	Loiasis	Parasitic_Infection	Loiasis
C34785	Loneliness	Mental_and_Behavioral_Signs_and_Symptoms	Loneliness
C34786	Long_QT_Syndrome	Arrhythmia	Long QT Syndrome	prolongation of Q-T interval combined with torsades de pointes and manifests as several different forms; may be acquired or congenital; may lead to serious arrhythmia and sudden cardiac death.
C34787	Lordosis	Non-Neoplastic_Bone_Disorder	Lordosis
C34788	Lower_Back_Pain	Back_Pain	Lower Back Pain
C34789	Lupus_Glomerulonephritis	Glomerulonephritis	Lupus Glomerulonephritis
C34790	Lymphangitis	Infectious_Disorder	Lymphangitis
C34791	Lymphocytosis	Hematopoietic_System_Finding	Lymphocytosis
C34792	Hemophagocytic_Lymphohistiocytosis	Hemophagocytic_Syndrome	Hemophagocytic Lymphohistiocytosis
C34793	Macular_Corneal_Dystrophy	Corneal_Dystrophy	Macular Corneal Dystrophy
C34794	Cystoid_Macular_Edema	Macular_Edema	Cystoid Macular Edema
C34795	Macular_Hole	Non-Neoplastic_Retinal_Disorder	Macular Hole
C34796	Single_Episode_of_Major_Depressive_Disorder	Mental_and_Behavioral_Signs_and_Symptoms	Single Episode of Major Depressive Disorder
C34797	Malaria	Parasitic_Infection	Malaria
C34798	Falciparum_Malaria	Malaria	Falciparum Malaria
C34799	Quartan_Malaria	Malaria	Quartan Malaria
C34800	Vivax_Malaria	Malaria	Vivax Malaria
C34801	Male_Erectile_Disorder	Male_Orgasmic_Disorder	Male Erectile Disorder
C34802	Malignant_Essential_Hypertension	Essential_Hypertension|Malignant_Hypertension	Malignant Essential Hypertension
C34803	Primary_Malignant_Neoplasm_of_Liver	Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm|Malignant_Hepato-Biliary_Neoplasm	Primary Malignant Neoplasm of Liver
C34804	Malposition_of_Heart_and_Cardiac_Apex	Congenital_Cardiovascular_Abnormality	Malposition of Heart and Cardiac Apex
C34805	Manic_Bipolar_Affective_Disorder	Bipolar_Disorder	Manic Bipolar Affective Disorder
C34806	Maple_Syrup_Urine_Disease	Genetic_Disorder	Maple Syrup Urine Disease
C34807	Marfan_s_Syndrome	Syndrome	Marfan's Syndrome
C34808	Mass	Finding	Mass
C34809	Maxillary_Sinusitis	Sinusitis	Maxillary Sinusitis
C34810	Megacolon	Intestinal_Disorder	Megacolon
C34811	Megaesophagus	Esophageal_Disorder	Megaesophagus
C34812	Melancholia	Psychiatric_Disorder	Melancholia
C34813	Meningoencephalitis	Central_Nervous_System_Infectious_Disorder	Meningoencephalitis
C34814	Menopausal_Syndrome	Syndrome	Menopausal Syndrome
C34815	Menstrual_Disorder	Genitourinary_Signs_and_Symptoms|Reproductive_System_Finding	Menstrual Disorder
C34816	Inborn_Errors_of_Metabolism	Metabolic_Disorder	Inborn Errors of Metabolism
C34817	Methemoglobinemia	Abnormal_Blood_and_Hematology_Test_Result	Methemoglobinemia
C34818	Metrorrhagia	Hemorrhage|Reproductive_System_Finding	Metrorrhagia
C34819	Mikulicz_Disease	Salivary_Gland_Disorder	Mikulicz Disease|Sicca Syndrome
C34820	Miliaria	Syndrome	Miliaria
C34821	Mixed_Hyperlipidemia	Hyperlipidemia	Mixed Hyperlipidemia
C34822	Closed_Monteggia_s_Fracture	Closed_Fracture	Closed Monteggia's Fracture
C34823	Mosquito-Born_Viral_Encephalitis	Viral_Encephalitis	Mosquito-Born Viral Encephalitis
C34824	Motion_Sickness	Symptom	Motion Sickness|Travel Sickness
C34825	Kawasaki_Disease	Vasculitis	Kawasaki Disease	systemic disease primarily of infants and young children, characterized by skin rash, swelling of hands and feet, enlarged cervical lymph nodes, "strawberry tongue", dry and cracked lips, high fevers, and coronary artery disease.
C34826	Mucous_Polyp_of_Cervix	Cervical_Non-Neoplastic_Disorder	Mucous Polyp of Cervix
C34827	Muscle_Cramp	Connective_and_Soft_Tissue_Finding|Symptom	Muscle Cramp|Cramp
C34828	Flaccidity	Connective_and_Soft_Tissue_Finding	Flaccidity
C34829	Myocardial_Degeneration	Myocardial_Disorder	Myocardial Degeneration
C34830	Cardiomyopathy	Myocardial_Disorder	Cardiomyopathy
C34831	Myocarditis	Myocardial_Disorder	Myocarditis
C34832	Myoclonic_Jerk	Nervous_System_Finding	Myoclonic Jerk
C34833	Myotonic_Cataract	Cataract	Myotonic Cataract
C34834	Myxedema	Hypothyroidism	Myxedema
C34835	Nabothian_Cyst	Uterine_Cervix_Cyst	Nabothian Cyst
C34836	Ingrown_Toenail	Congenital_or_Acquired_Anatomic_Abnormality	Ingrown Toenail
C34837	Nasopharyngitis	Nasopharyngeal_Disorder	Nasopharyngitis
C34838	Necatoriasis	Parasitic_Infection	Necatoriasis
C34839	Neck_Sprain	Sprain	Neck Sprain
C34840	Necrobiosis_Lipoidica	Non-Neoplastic_Skin_Disorder	Necrobiosis Lipoidica
C34841	Avascular_Necrosis_of_Bone	Bone_Necrosis	Avascular Necrosis of Bone
C34842	Alport_s_Syndrome	Syndrome	Alport's Syndrome|Hereditary Nephritis	hereditary disorder characterized by progressive sensorineural hearing loss, progressive pyelonephritis or glomerulonephritis, and, occasionally, ocular defects; transmitted as an autosomal dominant or X-linked trait.
C34843	Nephropathy	Non-Neoplastic_Renal_Disorder	Nephropathy
C34844	Minimal_Change_Glomerulonephritis	Glomerulonephritis	Minimal Change Glomerulonephritis
C34845	Nephrotic_Syndrome	Non-Neoplastic_Renal_Disorder|Syndrome	Nephrotic Syndrome
C34846	Nervous_Debility	Fatigue	Nervous Debility
C34847	Neuronitis	Non-Neoplastic_Central_Nervous_System_Disorder	Neuronitis
C34848	Neurosis	Anxiety_Disorder	Neurosis	class of mental disorders milder than psychosis, including hysteria, fugue, obsession, phobia, etc.
C34849	Newcastle_Disease	Viral_Infection	Newcastle Disease
C34850	Night_Blindness	Vision_Disorder	Night Blindness
C34851	Increased_NPN	Abnormal_Blood_and_Hematology_Test_Result	Increased NPN
C34852	Gangrenous_Stomatitis	Ulcerative_Stomatitis	Gangrenous Stomatitis
C34853	Non-Autoimmune_Hemolytic_Anemia	Acquired_Hemolytic_Anemia	Non-Autoimmune Hemolytic Anemia
C34854	Noonan_Syndrome	Syndrome	Noonan Syndrome
C34855	Norwegian_Scabies	Scabies	Norwegian Scabies
C34856	Acquired_Deformity_of_Nose	Nose_Deformity	Acquired Deformity of Nose
C34857	Numbness	Disturbance_of_Skin_Sensation	Numbness|Loss of Sensation
C34858	Morbid_Obesity	Obesity	Morbid Obesity
C34859	Occupational_Dermatitis	Dermatitis	Occupational Dermatitis
C34860	Oligospermia	Sexual_Dysfunction_and_Infertility	Oligospermia
C34861	Onchocerciasis	Parasitic_Infection	Onchocerciasis
C34862	Ocular_Onchocerciasis	Eye_Infection|Onchocerciasis	Ocular Onchocerciasis
C34863	Optic_Atrophy	Non-Neoplastic_Eye_Disorder	Optic Atrophy
C34864	Hereditary_Optic_Atrophy	Optic_Atrophy	Hereditary Optic Atrophy
C34865	Optical_Illusion	Vision_Disorder	Optical Illusion
C34866	Oral_Cavity_Submucous_Fibrosis	Non-Neoplastic_Oral_Cavity_Disorder	Oral Cavity Submucous Fibrosis
C34867	Organic_Anxiety_Disorder	Anxiety_Disorder	Organic Anxiety Disorder
C34868	Organic_Brain_Syndrome	Behavior-Related_Disorder|Syndrome	Organic Brain Syndrome	broad group of severe mental and behavioral disorders etiologically traceable to brain disease, injury, or toxicosis; psychosis associated with endocrine disorders, drugs, and metabolic or nutritional abnormalities.
C34869	Organic_Delusional_Syndrome	Organic_Brain_Syndrome	Organic Delusional Syndrome
C34870	Organic_Mental_Disorder	Central_Nervous_System_Disorder	Organic Mental Disorder
C34871	Organic_Affective_Syndrome	Organic_Brain_Syndrome	Organic Affective Syndrome
C34872	Organic_Personality_Syndrome	Organic_Brain_Syndrome	Organic Personality Syndrome
C34873	Ornithosis	Chlamydial_Infection	Ornithosis
C34874	Osgood-Schlatter_s_Disease	Juvenile_Osteochondrosis	Osgood-Schlatter's Disease
C34875	Osteitis_Fibrosa_Cystica	Non-Neoplastic_Bone_Disorder	Osteitis Fibrosa Cystica|Von Recklinghausen's Disease of Bone
C34876	Hip_Osteoarthritis	Osteoarthritis	Hip Osteoarthritis
C34877	Osteochondritis	Non-Neoplastic_Bone_Disorder	Osteochondritis
C34878	Osteochondritis_Dissecans	Osteochondritis	Osteochondritis Dissecans
C34879	Osteochondrosis	Non-Neoplastic_Bone_Disorder	Osteochondrosis
C34880	Bone_Necrosis	Non-Neoplastic_Bone_Disorder	Bone Necrosis|Osteonecrosis	Death of bone tissue due to traumatic or nontraumatic causes. --2004
C34881	Congenital_Deformity_of_Hip	Non-Neoplastic_Bone_Disorder	Congenital Deformity of Hip
C34882	Rheumatic_Heart_Disease	Non-Neoplastic_Heart_Disorder	Rheumatic Heart Disease
C34883	Multiple_Dislocations	Dislocation	Multiple Dislocations
C34884	Otitis	Ear_Infection	Otitis
C34885	Otitis_Media	Middle_Ear_Disorder|Otitis	Otitis Media
C34886	Secretory_Otitis_Media	Otitis_Media	Secretory Otitis Media
C34887	Post-operative_Pain	Pain	Post-operative Pain
C34888	Palmoplantar_Pustulosis	Dermatitis	Palmoplantar Pustulosis
C34889	Pancytopenia	Cytopenia	Pancytopenia
C34890	Panic_Disorder	Socialized_Conduct_Disorder	Panic Disorder	specific psychological phenomenon characterized by sudden onset of anxiety (often unrelated to objective events), accompanied by autonomic symptoms such as tachycardia, paresthesia, flushing, and sweating.
C34891	Paracoccidioidomycosis	Fungal_Infection	Paracoccidioidomycosis
C34892	Parakeratosis	Morphologic_Finding	Parakeratosis
C34893	Paraphimosis	Penile_Non-Neoplastic_Disorder	Paraphimosis
C34894	Paratyphoid_Fever_A	Paratyphoid_Fever	Paratyphoid Fever A
C34895	Paratyphoid_Fever_B	Paratyphoid_Fever	Paratyphoid Fever B
C34896	Paratyphoid_Fever_C	Paratyphoid_Fever	Paratyphoid Fever C
C34897	Paratyphoid_Fever	Bacterial_Infection	Paratyphoid Fever
C34898	Postencephalitic_Parkinsonism	Non-Neoplastic_Central_Nervous_System_Disorder	Postencephalitic Parkinsonism
C34899	Secondary_Parkinsonism	Non-Neoplastic_Central_Nervous_System_Disorder	Secondary Parkinsonism
C34900	Paroxysmal_Atrial_Tachycardia	Atrial_Tachycardia|Paroxysmal_Supraventricular_Tachycardia	Paroxysmal Atrial Tachycardia
C34901	Paroxysmal_Supraventricular_Tachycardia	Paroxysmal_Tachycardia|Supraventricular_Tachycardia	Paroxysmal Supraventricular Tachycardia
C34902	Paroxysmal_Ventricular_Tachycardia	Paroxysmal_Tachycardia|Ventricular_Arrhythmia	Paroxysmal Ventricular Tachycardia
C34903	Pars_Planitis	Non-Neoplastic_Eye_Disorder	Pars Planitis
C34904	Passive-Aggressive_Personality	Personality_Disorder	Passive-Aggressive Personality
C34905	Head_Lice	Lice	Head Lice|Pediculus humanus capitis	Small parasitic insects that can cause a itching red rash to the skin of the waist, shoulders, armpits, neck and pubic area. Commonly spread from person-to-person via close contact. The eggs (nits) of head lice can be mistaken for dandruff, but they are adherent to the hair shafts. (On-line Medical Dictionary)
C34906	Body_Lice	Lice	Body Lice|Pediculus humanus corporis	Body lice are tiny parasitic insects (Pediculus humanus corporis) that spread through close contact with other people. Body lice may be 2 - 3 mm long, whereas head and public lice are much smaller. They feed on human blood, and they lay their eggs and deposit their fecal matter on the skin (they may also lay their eggs in clothing). Infestation by body lice causes intense itching. When body lice are not feeding on blood, they live in the seams and folds of clothing. Body lice are transmitted by contact with infected clothing and bedding as well as by direct contact with an infected person. Risk factors include close (overcrowded) living conditions, and poor hygiene. (MedlinePlus Medical Encyclopedia)
C34907	Benign_Mucous_Membrane_Pemphigoid	Pemphigoid	Benign Mucous Membrane Pemphigoid
C34908	Pemphigoid	Non-Neoplastic_Skin_Disorder	Pemphigoid
C34909	Pemphigus	Non-Neoplastic_Skin_Disorder	Pemphigus
C34910	Pemphigus_Vulgaris	Pemphigus	Pemphigus Vulgaris
C34911	Penicillin_Allergy	Hypersensitivity	Penicillin Allergy
C34912	Perceptual_Distortion	Perception_Disturbance	Perceptual Distortion
C34913	Dentoalveolar_Abscess	Tooth_Abscess	Dentoalveolar Abscess
C34914	Periapical_Abscess_with_Sinus	Periapical_Dental_Abscess	Periapical Abscess with Sinus
C34915	Pericarditis	Heart_Disease	Pericarditis
C34916	Pericholangitis	Non-Neoplastic_Biliary_Tract_Disorder	Pericholangitis
C34917	Periodontal_Abscess	Tooth_Abscess	Periodontal Abscess
C34918	Periodontitis	Non-Neoplastic_Dental_Disorder	Periodontitis
C34919	Peripheral_Retinal_Degeneration	Retinal_Degeneration	Peripheral Retinal Degeneration
C34920	Chronic_Peritoneal_Effusion	Peritoneal_Effusion	Chronic Peritoneal Effusion
C34921	Ostium_Primum_Defect	Congenital_Abnormality|Non-Neoplastic_Heart_Disorder	Ostium Primum Defect
C34922	Personality_Disorder	Psychiatric_Disorder	Personality Disorder	when normal personality traits become inflexible and maladaptive, causing subjective distress or impaired social functioning, they can be considered disorders.
C34923	Stump_Hallucination	Perceptual_Distortion	Stump Hallucination
C34924	Pharyngoconjunctival_Fever	Viral_Infection	Pharyngoconjunctival Fever
C34925	Phlegmon	Inflammation	Phlegmon	Purulent inflammation of the cellular or areolar tissue.
C34926	School_Phobia	Phobia	School Phobia
C34927	Social_Phobia	Phobia	Social Phobia
C34928	Phocomelia	Ectromelia	Phocomelia
C34929	Photodermatitis	Dermatitis	Photodermatitis
C34930	Abnormal_Pigmentation	Other_Finding	Abnormal Pigmentation
C34931	Pilonidal_Cyst	Skin_Cyst	Pilonidal Cyst|Pilonidal Sinus
C34932	Aspiration_Pneumonia	Pneumonia	Aspiration Pneumonia
C34933	Poisoning	Injury	Poisoning
C34934	Polyradiculopathy	Non-Neoplastic_Central_Nervous_System_Disorder	Polyradiculopathy
C34935	Baker_s_Cyst	Cyst	Baker's Cyst
C34936	Post_Kala-Azar_Dermal_Leishmaniasis	Leishmaniasis|Skin_Infection	Post Kala-Azar Dermal Leishmaniasis
C34937	Postmenopausal_Hemorrhage	Hemorrhage|Reproductive_System_Finding	Postmenopausal Hemorrhage
C34938	Postoperative_Bleeding	Hemorrhage	Postoperative Bleeding	A condition in which hemorrhage occurs after completion of a surgical procedure. Postoperative bleeding may follow surgery immediately or may be delayed; it may be wound-related or not. --2004
C34939	Potassium_Deficiency	Nutritional_Disorder	Potassium Deficiency Disorder
C34940	Pre-Excitation_Syndrome	Non-Neoplastic_Heart_Disorder	Pre-Excitation Syndrome
C34941	Pregnancy_Complication	Complication|Reproductive_System_Finding	Pregnancy Complication
C34942	Diabetes_in_Pregnancy	Diabetes_Mellitus	Diabetes in Pregnancy
C34943	Toxemia_of_Pregnancy	Hypertension_Associated_Disorders_of_Pregnancy	Toxemia of Pregnancy	pregnancy induced hypertensive states, including EPH gestosis when edema and proteinuria accompany hypertension; other hypertensive disorders that develop during pregnancy or the puerperium are preeclampsia and eclampsia, either of which may be superimposed upon chronic hypertensive vascular or renal disease.
C34944	Abdominal_Pregnancy	Mouse_Ectopic_Pregnancy	Abdominal Pregnancy
C34945	Ectopic_Pregnancy	Pregnancy_Disorder	Ectopic Pregnancy	development of a fertilized ovum outside of the uterine cavity.
C34946	Ovarian_Pregnancy	Mouse_Ectopic_Pregnancy	Ovarian Pregnancy
C34947	Tubal_Pregnancy	Mouse_Ectopic_Pregnancy	Tubal Pregnancy
C34948	Puncture_Wound	Injury	Puncture Wound
C34949	Primary_Insomnia	Insomnia	Primary Insomnia
C34950	Proctosigmoiditis	Non-Neoplastic_Gastrointestinal_Disorder	Proctosigmoiditis
C34951	Progeria	Syndrome	Progeria|Hutchinson-Gilford Disease|Premature Senility Syndrome
C34952	Protein_Energy_Malnutrition	Malnutrition	Protein Energy Malnutrition
C34953	Protozoal_Infection	Infectious_Disorder	Protozoal Infection
C34954	Pruritus_Vulvae	Pruritus	Pruritus Vulvae
C34955	Pseudogout	Arthritis|Metabolic_Disorder	Pseudogout
C34956	Psychosomatic_Disorder	Psychiatric_Disorder	Psychosomatic Disorder	characterized by physical symptoms and demonstrable structural or physiological changes in which emotional factors are believed to play a major etiologic role.
C34957	Drug-Induced_Psychosis	Psychiatric_Disorder	Drug-Induced Psychosis
C34958	Female_Orgasmic_Disorder	Female_Non-Neoplastic_Reproductive_System_Disorder	Female Orgasmic Disorder
C34959	Male_Orgasmic_Disorder	Male_Non-Neoplastic_Reproductive_System_Disorder	Male Orgasmic Disorder
C34960	Psychosexual_Dysfunction_with_Inhibited_Sexual_Excitement	Sexual_Dysfunction	Psychosexual Dysfunction with Inhibited Sexual Excitement
C34961	Congenital_Infundibular_Stenosis	Congenital_Abnormality	Congenital Infundibular Stenosis
C34962	Pulp_Degeneration	Non-Neoplastic_Dental_Disorder	Pulp Degeneration
C34963	Henoch-Schonlein_Purpura	Vascular_Purpura|Vasculitis	Henoch-Schonlein Purpura
C34964	Pyelitis	Genitourinary_System_Infection|Non-Neoplastic_Renal_Disorder	Pyelitis
C34965	Pyelonephritis	Non-Neoplastic_Renal_Disorder	Pyelonephritis
C34966	Pyloric_Stenosis	Stomach_Disorder	Pyloric Stenosis
C34967	Lobular_Capillary_Hemangioma_of_Skin_and_Subcutaneous_Tissue	Hemangioma_of_the_Skin|Lobular_Capillary_Hemangioma	Lobular Capillary Hemangioma of Skin and Subcutaneous Tissue|Pyogenic Granuloma of Skin and Subcutaneous Tissue
C34968	Pyosalpinx	Fallopian_Tube_Non-Neoplastic_Disorder|Genitourinary_System_Infection	Pyosalpinx
C34969	Pyridoxine_Deficiency	Vitamin_B_Deficiency	Pyridoxine Deficiency
C34970	Q_Fever	Bacterial_Infection	Q Fever
C34971	Rat-Bite_Fever	Zoonotic_Bacterial_Infection	Rat-Bite Fever
C34972	Raynaud_s_Disease	Non-Neoplastic_Vascular_Disorder	Raynaud's Disease	intermittent attacks of ischemia in the fingers, toes, ears, or nose, accompanied by pain, pallor, and prickling; phenomenon applies to secondary symptoms, disease when cause is unknown.
C34973	Rectal_Prolapse	Prolapse	Rectal Prolapse
C34974	Pure_Red_Cell_Aplasia	Non-Neoplastic_Hematologic_Disorder	Pure Red Cell Aplasia
C34975	Reiter_s_Syndrome	Syndrome	Reiter's Syndrome
C34976	Tick-Born_Relapsing_Fever	Rickettsiosis	Tick-Born Relapsing Fever
C34977	Reticuloendothelial_Hyperplasia	Hyperplasia	Reticuloendothelial Hyperplasia
C34978	Retinal_Artery_Occlusion	Arterial_Occlusion|Retinal_Vascular_Occlusion	Retinal Artery Occlusion
C34979	Retinal_Degeneration	Non-Neoplastic_Retinal_Disorder	Retinal Degeneration
C34980	Retinal_Vascular_Occlusion	Non-Neoplastic_Retinal_Disorder|Retinal_Vascular_Disorder	Retinal Vascular Occlusion
C34981	Retinal_Vein_Occlusion	Retinal_Vascular_Occlusion	Retinal Vein Occlusion
C34982	Retrolental_Fibroplasia	Non-Neoplastic_Retinal_Disorder	Retrolental Fibroplasia
C34983	Reye_s_Syndrome	Syndrome	Reye's Syndrome
C34984	Rheumatic_Fever	Bacterial_Infection	Rheumatic Fever
C34985	Acute_Rheumatic_Heart_Disease	Rheumatic_Heart_Disease	Acute Rheumatic Heart Disease
C34986	Rhinitis	Non-Neoplastic_Nasal_Cavity_Disorder	Rhinitis	An inflammation of the mucous membrane lining the nose, usually associated with nasal discharge.
C34987	Atopic_Rhinitis	Rhinitis	Atopic Rhinitis
C34988	Vasomotor_Rhinitis	Rhinitis	Vasomotor Rhinitis
C34989	Rhinophyma	Non-Neoplastic_Nasal_Cavity_Disorder	Rhinophyma
C34990	Rib_Fracture	Fracture	Rib Fracture|Fracture of Rib
C34991	Rickettsiosis	Bacterial_Infection	Rickettsiosis|Rickettsial Infectious Disease|Rickettsial Infectious Disorder
C34992	Congenital_Rubella	Viral_Infection	Congenital Rubella
C34993	Salivary_Duct_Stone	Salivary_Gland_Stone	Salivary Duct Stone|Salivary Duct Calculus
C34994	Salivary_Gland_Stone	Head_and_Neck_Finding|Stone	Salivary Gland Stone|Salivary Gland Calculus|Sialolithiasis
C34995	Sarcoidosis	Autoimmune_Disease	Sarcoidosis	inflammatory disease characterized by small lumps or granulomas in lymph nodes and other organs.
C34996	Cutaneous_Sarcoidosis	Non-Neoplastic_Skin_Disorder|Sarcoidosis	Cutaneous Sarcoidosis
C34997	Pulmonary_Sarcoidosis	Non-Neoplastic_Lung_Disorder|Sarcoidosis	Pulmonary Sarcoidosis|Lung Sarcoidosis
C34998	Scabies	Skin_Infection	Scabies
C34999	Juvenile_Osteochondrosis_of_Spine	Juvenile_Osteochondrosis	Juvenile Osteochondrosis of Spine
C35000	Schistosomiasis	Parasitic_Infection	Schistosomiasis	parasitic disease of tropical and subtropical countries; characterized initially by fever, chills, and abdominal and lower back pain; untreated patients may develop jaundice, liver cirrhosis, bladder tumors, and kidney failure.
C35001	Schistosoma_Japonicum_Infection	Schistosomiasis	Schistosoma Japonicum Infection
C35002	Schistosoma_Mansoni_Infection	Schistosomiasis	Schistosoma Mansoni Infection
C35003	Catatonic_Type_Schizophrenia	Schizophrenia	Catatonic Type Schizophrenia
C35004	Childhood_Schizophrenia	Schizophrenia	Childhood Schizophrenia
C35005	Disorganized_Type_Schizophrenia	Schizophrenia	Disorganized Type Schizophrenia
C35006	Paranoid_Type_Schizophrenia	Schizophrenia	Paranoid Type Schizophrenia	psychotic behavior accompanied simultaneously by persecutory or grandiose delusions (paranoia) and hallucinations (schizophrenia); delusional jealousy may be present.
C35007	Residual_Type_Schizophrenia	Schizophrenia	Residual Type Schizophrenia
C35008	Schwartz_Syndrome	Syndrome	Schwartz Syndrome|Myotonic Chondrodystrophy
C35009	Sclerema_Neonatorum	Non-Neoplastic_Soft_Tissue_Disorder	Sclerema Neonatorum
C35010	Scurvy	Vitamin_Deficiency_Disorder	Scurvy
C35011	Sea_Sickness	Motion_Sickness	Sea Sickness
C35012	Senile_Cataract	Cataract	Senile Cataract
C35013	Senile_Corneal_Change	Pathologic_Process	Senile Corneal Change	Senile Corneal Change involves degenerative changes of the cornea related to aging that are highly influenced by changes in the corneal endothelium. Changes include corneal topography, increased density, decreased hydration of the corneal stroma, and epithelial basement membrane dystrophy; The stroma appears hazier than in younger eyes and reduces light transmission. Changes may also include age-related stromal degeneration and deposition.
C35014	Separation_Anxiety_Disorder	Anxiety_Disorder	Separation Anxiety Disorder
C35015	Shivering	Symptom	Shivering
C35016	Shock	Fluid_and_Electrolyte_Manifestation	Shock|Circulatory Collapse	a profound hemodynamic and metabolic disturbance characterized by the failure of the circulatory system to maintain adequate perfusion of vital organs; causes inadequate delivery of nutrients and insufficient removal of cellular waste products to and from the tissues.
C35017	Hemorrhagic_Shock	Shock	Hemorrhagic Shock	hemorrhage decreases the mean systemic filling pressure, therefore decreasing venous return; as a result, the cardiac output falls below normal, and shock ensues.
C35018	Septic_Shock	Shock	Septic Shock	shock caused by infection; frequently caused by gram negative bacteria, although some cases have been caused by other bacteria, viruses, fungi, and protozoa; characterized by fever, chills, tachycardia, tachypnea, and hypotension.
C35019	Surgical_Shock	Shock	Surgical Shock
C35020	Shoulder_Dislocation	Joint_Dislocation	Shoulder Dislocation|Dislocated Shoulder
C35021	Shoulder_Fracture	Upper_Extremity_Fracture	Shoulder Fracture
C35022	Shoulder_Pain	Pain	Shoulder Pain
C35023	Endemic_Goiter	Goiter	Endemic Goiter|Simple Goiter
C35024	Sinusitis	Head_and_Neck_Infection|Non-Neoplastic_Paranasal_Sinus_Disorder	Sinusitis
C35025	Skin_Infection	Infectious_Disorder_by_Site|Non-Neoplastic_Skin_Disorder	Skin Infection
C35026	Skin_Pigmentation	Pigmentation	Skin Pigmentation
C35027	Smallpox	Viral_Infection	Smallpox
C35028	Modified_Smallpox	Smallpox	Modified Smallpox
C35029	Socialized_Conduct_Disorder	Behavior-Related_Disorder|Psychiatric_Disorder	Socialized Conduct Disorder
C35030	Sparganosis	Parasitic_Infection	Sparganosis
C35031	Sphenoidal_Sinusitis	Sinusitis	Sphenoidal Sinusitis
C35032	Splenic_Rupture	Rupture	Splenic Rupture
C35033	Spondylolisthesis	Non-Neoplastic_Bone_Disorder	Spondylolisthesis
C35034	Spondylolysis	Non-Neoplastic_Bone_Disorder	Spondylolysis
C35035	Sprain	Injury	Sprain
C35036	Staphylococcus_Aureus_Gastroenteritis	Infectious_Disorder_by_Site|Staphylococcal_Infection	Staphylococcus Aureus Gastroenteritis
C35037	Staphylococcal_Food_Poisoning	Staphylococcal_Infection	Staphylococcal Food Poisoning
C35038	Staphylococcal_Infection	Bacterial_Infection	Staphylococcal Infection
C35039	Ulcerative_Stomatitis	Stomatitis	Ulcerative Stomatitis
C35040	Strabismus	Vision_Disorder	Strabismus
C35041	Stress	Symptom	Stress	the biological response to noxious, demanding, or unpleasant stimuli or conditions; do not confuse stress with STRESSOR, which is the stimulus.
C35042	Female_Stress_Incontinence	Non-Neoplastic_Bladder_Disorder	Female Stress Incontinence
C35043	Stutter	Speech_Manifestations	Stutter	disorder in which speech is involuntarily interrupted by hesitations, repetitions, and spasms of the muscles involved in breathing or vocalization.
C35044	Subclavian_Steal_Syndrome	Syndrome	Subclavian Steal Syndrome
C35045	Subconjunctival_Hemorrhage	Eye_and_Ear_Finding|Hemorrhage	Subconjunctival Hemorrhage
C35046	Withdrawal_Syndrome	Behavior-Related_Disorder	Substance Withdrawal Syndrome|Withdrawal Syndrome	Substance withdrawal syndrome - a substance-specific organic brain syndrome that follows the discontinuation of administration or use, or reduction in intake of an addictive substance, e.g. opioids, barbiturates and alcohol; amphetamines or similarly acting sympathomimetics; cocaine; nicotine; sedatives, hypnotics, or anxiolytics. Syndrome manifests with diverse, often painful physical and psychological symptoms, which include but not limited to intense drug craving, anxiety, depression, insomnia, nausea, perspiration, body aches, tremors, hallucinations, and convulsions.
C35047	Sun_Stroke	Injury	Sun Stroke
C35048	Superficial_Injury_of_Cornea	Corneal_Injury	Superficial Injury of Cornea
C35049	Wound_Breakdown	Connective_and_Soft_Tissue_Finding	Wound Breakdown
C35050	Surgical_Wound_Infection	Wound_Infection	Surgical Wound Infection
C35051	Diaphoresis	Symptom	Diaphoresis
C35052	Sweating_Fever	Fever	Sweating Fever
C35053	Syncope	Neurological_Signs_and_Symptoms	Syncope	A spontaneous loss of consciousness caused by insufficient blood to the brain.
C35055	Syphilis	Sexually_Transmitted_Disorder	Syphilis
C35056	Latent_Syphilis	Latent_Infection|Syphilis	Latent Syphilis
C35057	Tabes_Dorsalis	Syphilis	Tabes Dorsalis
C35058	Atrioventricular_Nodal_Reentry_Tachycardia	Nodal_Arrhythmia	Atrioventricular Nodal Reentry Tachycardia
C35059	Junctional_Tachycardia	Supraventricular_Arrhythmia	Junctional Tachycardia
C35060	Paroxysmal_Tachycardia	Arrhythmia	Paroxysmal Tachycardia
C35061	Supraventricular_Tachycardia	Supraventricular_Arrhythmia	Supraventricular Tachycardia
C35062	Takayasu_s_Arteritis	Arteritis	Takayasu's Arteritis
C35063	Teething_Syndrome	Dental_Developmental_Disorder|Syndrome	Teething Syndrome
C35064	Hereditary_Hemorrhagic_Telangiectasia	Genetic_Disorder|Telangiectasia	Hereditary Hemorrhagic Telangiectasia|Osler-Weber-Rendu Disease
C35065	Temporal_Arteritis	Granulomatous_Arteritis	Temporal Arteritis|Giant Cell Arteritis
C35066	Temporomandibular_Joint_Dysfunction_Syndrome	Non-Neoplastic_Bone_Disorder	Temporomandibular Joint Dysfunction Syndrome
C35067	Lateral_Epicondylitis	Epicondylitis	Lateral Epicondylitis
C35068	Tetanic_Cataract	Cataract	Tetanic Cataract
C35069	Thalassemia	Hemoglobinopathy	Thalassemia
C35070	Buerger_s_Disease	Peripheral_Vascular_Disorder	Buerger's Disease|Thromboangiitis Obliterans
C35071	Subacute_Thyroiditis	Thyroiditis	Subacute Thyroiditis
C35072	Favus	Skin_Infection	Favus
C35073	Deep_Seated_Dermatophytosis	Skin_Infection	Deep Seated Dermatophytosis
C35074	Tobacco_Use_Disorder	Behavior-Related_Disorder	Tobacco Use Disorder
C35075	Hairy_Tongue	Non-Neoplastic_Oral_Cavity_Disorder	Hairy Tongue
C35076	Tooth_Abrasion	Injury	Tooth Abrasion
C35077	Dental_Disorder	Oral_Cavity_Disorder	Dental Disorder|Tooth Disorder
C35078	Tourette_s_Syndrome	Syndrome	Tourette's Syndrome	neuropsychological disorder related to alterations in dopamine metabolism and neurotransmission involving frontal-subcortical neuronal circuits; both multiple motor and one or more vocal tics need to be present with tics occurring many times a day, nearly daily, over a period of more than one year; disturbance causes marked distress or significant impairment in social, occupational, or other important areas of functioning.
C35079	Tracheal_Disorder	Respiratory_Disorder	Tracheal Disorder|Tracheal Disease
C35080	Tracheoesophageal_Fistula	Fistula	Tracheoesophageal Fistula|Tracheo-esophageal Fistula
C35081	Traumatic_Myositis_Ossificans	Myositis	Traumatic Myositis Ossificans
C35082	Traumatic_Subcutaneous_Emphysema	Injury	Traumatic Subcutaneous Emphysema
C35083	Trichomonas_Vaginitis	Trichomonas_Infection	Trichomonas Vaginitis
C35084	Gambian_Trypanosomiasis	Tropical_Disease	Gambian Trypanosomiasis
C35085	Rhodesian_Trypanosomiasis	Tropical_Disease	Rhodesian Trypanosomiasis
C35086	Miliary_Tuberculosis	Tuberculosis	Miliary Tuberculosis
C35087	Pott_s_Disease	Tuberculosis	Pott's Disease
C35088	Tuberculous_Fibrosis_of_Lung	Lung_Tuberculosis	Tuberculous Fibrosis of Lung
C35089	Typhoid_Fever	Bacterial_Infection	Typhoid Fever	acute systemic febrile infection caused by Salmonella typhi.
C35090	Umbilical_Hernia_without_mention_of_Obstruction_or_Gangrene	Hernia_without_mention_of_Obstruction_or_Gangrene	Umbilical Hernia without mention of Obstruction or Gangrene
C35091	Undersocialized_Conduct_Disorder_Aggressive_Type	Socialized_Conduct_Disorder	Undersocialized Conduct Disorder, Aggressive Type
C35092	Attention_Deficit_Disorder	Psychiatric_Disorder	Attention Deficit Disorder	behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity; although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant; symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood.
C35093	Solitary_Bone_Cyst	Non-Neoplastic_Bone_Disorder	Solitary Bone Cyst
C35094	Unipolar_Depression	Depression	Unipolar Depression
C35095	Perinatal_Disorder	Diseases_and_Disorders	Perinatal Disorder
C35096	Deformity_of_Forearm	Congenital_or_Acquired_Anatomic_Abnormality	Deformity of Forearm
C35098	Idiopathic_Neuropathy	Neuropathy	Idiopathic Neuropathy
C35099	Local_Infection_of_Skin_and_Subcutaneous_Tissue	Skin_Infection	Local Infection of Skin and Subcutaneous Tissue
C35100	Nonpsychotic_Mental_Disorder_Following_Organic_Brain_Damage	Organic_Mental_Disorder	Nonpsychotic Mental Disorder Following Organic Brain Damage
C35101	Pruritic_Disorder	Non-Neoplastic_Skin_Disorder	Pruritic Disorder
C35102	Transient_Organic_Mental_Disorder	Organic_Mental_Disorder	Transient Organic Mental Disorder
C35103	Uremia	Increased_NPN	Uremia
C35105	Increased_Uric_Acid_Level	Abnormal_Laboratory_Test	Increased Uric Acid Level
C35106	Female_Genitourinary_Fistula	Genitourinary_Fistula	Female Genitourinary Fistula|Female Urogenital Fistula
C35107	Congenital_Genitourinary_Abnormality	Congenital_Abnormality	Congenital Genitourinary Abnormality
C35108	Uterine_Prolapse	Prolapse|Uterine_Non-Neoplastic_Disorder	Uterine Prolapse
C35109	Anterior_Uveitis	Uveitis	Anterior Uveitis
C35110	Intermediate_Uveitis	Uveitis	Intermediate Uveitis
C35111	Posterior_Uveitis	Uveitis	Posterior Uveitis
C35112	Vaginal_Itching	Genitourinary_Signs_and_Symptoms|Reproductive_System_Finding	Vaginal Itching
C35113	Psychogenic_Vaginismus	Genitourinary_Signs_and_Symptoms|Reproductive_System_Finding	Psychogenic Vaginismus
C35114	Varicose_Vein	Cardiovascular_System_Finding	Varicose Vein
C35115	Varicose_Vein_of_Lower_Extremities_with_Inflammation	Varicose_Vein_of_Lower_Extremities	Varicose Vein of Lower Extremities with Inflammation
C35116	Conjunctival_Vascular_Disorder	Conjunctival_Disorder|Ocular_Vascular_Disorder	Conjunctival Vascular Disorder
C35117	Vascular_Disorder	Cardiovascular_Disorder	Vascular Disorder
C35118	Vascular_Headache	Headache	Vascular Headache
C35119	Allergic_Cutaneous_Angiitis	Vasculitis	Allergic Cutaneous Angiitis
C35120	Vasovagal_Syncope	Syncope	Vasovagal Syncope
C35121	Venezuelan_Equine_Fever	Viral_Hemorrhagic_Fever	Venezuelan Equine Fever
C35122	Ventral_Hernia_without_mention_of_Obstruction_or_Gangrene	Hernia_without_mention_of_Obstruction_or_Gangrene	Ventral Hernia without mention of Obstruction or Gangrene
C35123	Vertebral_Artery_Syndrome	Arterial_Occlusion|Syndrome	Vertebral Artery Syndrome
C35124	Viral_Hepatitis	Gastrointestinal_Infection|Hepatitis	Viral Hepatitis
C35125	Viremia	Abnormal_Blood_and_Hematology_Test_Result	Viremia	the presence of viruses in the blood.
C35126	Vision_Disorder	Disorder_by_Site	Vision Disorder|Visual Disorder
C35127	Partial_Sight	Eye_and_Ear_Finding	Partial Sight
C35128	Visual_Discomfort	Symptom	Visual Discomfort
C35129	Vitamin_B_Deficiency	Abnormal_Blood_and_Hematology_Test_Result	Vitamin B Deficiency
C35130	Volkmann_s_Ischemic_Contracture	Non-Neoplastic_Soft_Tissue_Disorder	Volkmann's Ischemic Contracture
C35131	Vulvovaginitis	Female_Non-Neoplastic_Reproductive_System_Disorder	Vulvovaginitis
C35132	Wolff-Parkinson-White_Syndrome	Syndrome	Wolff-Parkinson-White Syndrome
C35133	Wolfram_Syndrome	Syndrome	Wolfram Syndrome
C35134	Xeroderma	Non-Neoplastic_Skin_Disorder	Xeroderma
C35135	Operative_Hemorrhage	Hemorrhage	Operative Hemorrhage
C35136	Peripheral_Vascular_Disorder	Non-Neoplastic_Vascular_Disorder	Peripheral Vascular Disorder
C35137	Ankle_Injury	Lower_Leg_Injury	Ankle Injury
C35138	Pharyngoesophageal_Diverticulum	Diverticulum	Pharyngoesophageal Diverticulum|Zenker's Diverticulum
C35139	Alagille_Syndrome	Syndrome	Alagille Syndrome
C35140	Dental_Phobia	Phobia	Dental Phobia
C35141	Microcytic_Anemia	Anemia	Microcytic Anemia
C35142	Normocytic_Anemia	Anemia	Normocytic Anemia
C35143	Chills	Body_Temperature_Associated_Symptom	Chills|Chill	A sensation of cold that often marks the start of an infection and the development of a fever.
C35144	Vasospasm	Cardiovascular_System_Finding	Vasospasm|Vasoconstriction
C35145	Acute_Appendicitis	Intestinal_Disorder	Acute Appendicitis
C35146	Chronic_Cholecystitis	Cholecystitis	Chronic Cholecystitis
C35147	Monocytosis	Abnormal_Hematology_Test_Result	Monocytosis
C35148	Mycotic_Aneurysm	Aneurysm	Mycotic Aneurysm
C35149	Bullous_Dermatitis	Dermatitis	Bullous Dermatitis
C35150	Eosinophilic_Pneumonia	Pneumonia	Eosinophilic Pneumonia
C35151	Chronic_Sinusitis	Sinusitis	Chronic Sinusitis
C35152	Acute_Cholecystitis	Cholecystitis	Acute Cholecystitis
C35153	Fracture_of_Pelvis	Fracture	Fracture of Pelvis
C35154	Foreign_Body_in_Esophagus	Foreign_Body_in_Gastrointestinal_Tract	Foreign Body in Esophagus
C35155	Adnexal_Mass	Mass	Adnexal Mass
C35156	Elbow_Injury	Limb_Injury	Elbow Injury
C35157	Foot_Injury	Leg_Injury	Foot Injury
C35158	Lower_Respiratory_Tract_Infection	Infectious_Lung_Disorder	Lower Respiratory Tract Infection|Lower Respiratory Tract Inflammation
C35159	Pulmonary_Mass	Mass	Pulmonary Mass|Lung Mass
C35160	Neck_Mass	Mass	Neck Mass|Neck Lump
C35161	Nipple_Discharge	Fluid_Discharge	Nipple Discharge|nipple discharge	Fluid coming from the nipple.
C35162	Campylobacter_Gastroenteritis	Bacterial_Gastroenteritis	Campylobacter Gastroenteritis
C35163	Skin_Atrophy	Non-Neoplastic_Skin_Disorder	Skin Atrophy|Atrophy of Skin
C35164	Neutrophilia	Abnormal_Hematology_Test_Result	Neutrophilia
C35165	Accidental_Injury	Accident	Accidental Injury
C35166	Manic_Psychosis	Affective_Psychosis	Manic Psychosis
C35167	Hypocellular_Bone_Marrow	Abnormal_Bone_Marrow_Test_Result	Hypocellular Bone Marrow|Bone Marrow Hypoplasia
C35168	Megakaryocytes_Increased	Abnormal_Bone_Marrow_Test_Result	Megakaryocytes Increased in Bone Marrow
C35169	Pregnancy_Disorder	Female_Reproductive_System_Disorder	Pregnancy Disorder
C35170	Retinal_Vascular_Disorder	Ocular_Vascular_Disorder|Retinal_Disorder	Retinal Vascular Disorder
C35171	Toxic_Nodular_Goiter	Goiter	Toxic Nodular Goiter
C35172	Congenital_Aphakia	Aphakia|Congenital_Lens_Disorder	Congenital Aphakia
C35173	Chronic_Glomerulonephritis	Glomerulonephritis	Chronic Glomerulonephritis
C35174	Mosquito-Born_Hemorrhagic_Fever	Viral_Hemorrhagic_Fever	Mosquito-Born Hemorrhagic Fever
C35175	Ancylostomiasis_due_to_Ancylostoma_Braziliense	Ancylostomiasis	Ancylostomiasis due to Ancylostoma Braziliense
C35176	Trichomonas_Prostatitis	Prostatitis|Trichomonas_Infection	Trichomonas Prostatitis
C35177	Malignant_Uvula_Neoplasm	Malignant_Soft_Palate_Neoplasm	Malignant Uvula Neoplasm|Malignant Uvula Tumor|Malignant Uvula Tumour|Malignant Uvular Neoplasm|Malignant Uvular Tumor|Malignant Uvular Tumour
C35178	Malignant_Neoplasm_of_Lower_Jaw_Bone	Malignant_Bone_Neoplasm	Malignant Neoplasm of Lower Jaw Bone
C35180	Gastrointestinal_Carcinoma_in_situ	Carcinoma_in_situ|Gastrointestinal_Intraepithelial_Neoplasia	Gastrointestinal Carcinoma In Situ
C35181	Latent_Subchronic_Schizophrenia	Latent_Schizophrenia|Subchronic_Schizophrenia	Latent Subchronic Schizophrenia
C35182	Latent_Chronic_Schizophrenia	Chronic_Schizophrenia|Latent_Schizophrenia	Latent Chronic Schizophrenia
C35183	Residual_Subchronic_Schizophrenia	Residual_Type_Schizophrenia|Subchronic_Schizophrenia	Residual Subchronic Schizophrenia
C35184	Residual_Chronic_Schizophrenia	Chronic_Schizophrenia|Residual_Type_Schizophrenia	Residual Chronic Schizophrenia
C35185	Subchronic_Schizophrenia	Schizophrenia	Subchronic Schizophrenia
C35186	Physiological_Malfunction_Arising_from_Mental_Factor	Psychosomatic_Disorder	Physiological Malfunction Arising from Mental Factor
C35187	Musculoskeletal_Malfunction_Arising_from_Mental_Factor	Non-Neoplastic_Connective_and_Soft_Tissue_Disorder|Psychosomatic_Disorder	Musculoskeletal Malfunction Arising from Mental Factor
C35188	Skin_Disorder_Arising_from_Mental_Factor	Non-Neoplastic_Skin_Disorder|Psychosomatic_Disorder	Skin Disorder Arising from Mental Factor
C35189	Genitourinary_Malfunction_Arising_from_Mental_Factor	Psychosomatic_Disorder	Genitourinary Malfunction Arising from Mental Factor
C35190	Endocrine_Disorder_Arising_from_Mental_Factor	Non-Neoplastic_Endocrine_Disorder|Psychosomatic_Disorder	Endocrine Disorder Arising from Mental Factor
C35191	Adjustment_Reaction_with_Prolonged_Depressive_Reaction	Reactive_Depression	Adjustment Reaction with Prolonged Depressive Reaction
C35192	Partial_Retinal_Arterial_Occlusion	Retinal_Artery_Occlusion	Partial Retinal Arterial Occlusion
C35193	Transient_Retinal_Arterial_Occlusion	Retinal_Artery_Occlusion	Transient Retinal Arterial Occlusion
C35194	Hereditary_Retinal_Dystrophy	Retinal_Dystrophy	Hereditary Retinal Dystrophy
C35195	Acute_Conjunctivitis	Conjunctivitis	Acute Conjunctivitis
C35196	Pseudomembranous_Conjunctivitis	Conjunctivitis	Pseudomembranous Conjunctivitis
C35197	Chronic_Conjunctivitis	Conjunctivitis	Chronic Conjunctivitis
C35198	Eyelid_Vascular_Disorder	Eyelid_Disorder|Vascular_Disorder	Eyelid Vascular Disorder
C35199	Otorrhea	Eye_and_Ear_Finding|Fluid_Discharge	Otorrhea
C35200	Acute_Rheumatic_Pericarditis	Acute_Rheumatic_Heart_Disease|Pericarditis	Acute Rheumatic Pericarditis
C35201	Acute_Rheumatic_Endocarditis	Acute_Rheumatic_Heart_Disease	Acute Rheumatic Endocarditis
C35202	Acute_Rheumatic_Myocarditis	Acute_Myocarditis|Acute_Rheumatic_Heart_Disease	Acute Rheumatic Myocarditis
C35203	Unspecified_Renovascular_Hypertension	Hypertension	Unspecified Renovascular Hypertension
C35204	Acute_Myocardial_Infarction	Myocardial_Infarction	Acute Myocardial Infarction
C35205	Old_Myocardial_Infarction	Myocardial_Infarction	Old Myocardial Infarction
C35206	Acute_Myocarditis	Myocarditis	Acute Myocarditis
C35207	Non-Traumatic_Extradural_Hemorrhage	Hemorrhage	Non-Traumatic Extradural Hemorrhage
C35208	Varicose_Vein_of_Lower_Extremities	Varicose_Vein	Varicose Vein of Lower Extremities
C35209	Femoral_Hernia_with_Obstruction	Femoral_Hernia	Femoral Hernia with Obstruction
C35210	Crohn_s_Disease_of_Small_Intestine	Crohn_s_Disease	Crohn's Disease of Small Intestine
C35211	Crohn_s_Colitis	Crohn_s_Disease	Crohn's Colitis
C35212	Ischemic_Bowel_Disease	Intestinal_Disorder|Non-Neoplastic_Vascular_Disorder	Ischemic Bowel Disease
C35213	Acute_Glomerulonephritis	Glomerulonephritis	Acute Glomerulonephritis
C35214	Nephrotic_Syndrome_with_Lesion_of_Proliferative_Glomerulonephritis	Nephrotic_Syndrome	Nephrotic Syndrome with Lesion of Proliferative Glomerulonephritis
C35215	Nephrotic_Syndrome_with_Lesion_of_Membranous_Glomerulonephritis	Nephrotic_Syndrome	Nephrotic Syndrome with Lesion of Membranous Glomerulonephritis
C35216	Nephrotic_Syndrome_with_Lesion_of_Membranoproliferative_Glomerulonephritis	Nephrotic_Syndrome	Nephrotic Syndrome with Lesion of Membranoproliferative Glomerulonephritis
C35217	Chronic_Glomerulonephritis_with_Lesion_of_Proliferative_Glomerulonephritis	Chronic_Glomerulonephritis	Chronic Glomerulonephritis with Lesion of Proliferative Glomerulonephritis
C35218	Penile_Vascular_Disorder	Penile_Disorder|Vascular_Disorder	Penile Vascular Disorder
C35219	Irregular_Menstruation	Menstrual_Disorder	Irregular Menstruation
C35220	Postcoital_Bleeding	Hemorrhage|Reproductive_System_Finding	Postcoital Bleeding
C35221	Abortion	Pregnancy_Complication	Abortion
C35222	Unspecified_Antepartum_Hypertension	Hypertension	Unspecified Antepartum Hypertension
C35223	Unspecified_Postpartum_Hypertension	Postpartum_Hypertension	Unspecified Postpartum Hypertension
C35224	Dermatitis_due_to_Unspecified_Substance_taken_Internally	Dermatitis	Dermatitis due to Unspecified Substance taken Internally
C35225	Arthropathy_in_Behcet_s_Syndrome	Arthropathy	Arthropathy in Behcet's Syndrome
C35226	Aseptic_Necrosis_of_Head_of_Humerus	Aseptic_Necrosis_of_Bone	Aseptic Necrosis of Head of Humerus
C35227	Acquired_Hallux_Valgus	Hallux_Valgus	Acquired Hallux Valgus
C35228	Congenital_Anemia	Anemia	Congenital Anemia
C35229	Closed_Fracture_of_Mandible_Multiple_Sites	Closed_Fracture_of_Mandible	Closed Fracture of Mandible, Multiple Sites
C35230	Closed_Fracture_of_Ribs_Multiple_Sites	Closed_Fracture_of_Rib	Closed Fracture of Ribs, Multiple Sites
C35231	Open_Fracture_of_Carpal_Bone	Carpal_Bone_Fracture|Open_Fracture	Open Fracture of Carpal Bone
C35232	Closed_Fracture_of_Metacarpal_Bone	Closed_Fracture|Fracture_of_Metacarpal_Bone	Closed Fracture of Metacarpal Bone
C35233	Open_Fracture_of_Metacarpal_Bone	Fracture_of_Metacarpal_Bone	Open Fracture of Metacarpal Bone
C35234	Injury_to_Diaphragm_with_Open_Wound_into_Cavity	Injury_to_Diaphragm	Injury to Diaphragm with Open Wound into Cavity
C35235	Injury_to_Esophagus_without_mention_of_Open_Wound_into_Cavity	Injury_to_Esophagus	Injury to Esophagus without mention of Open Wound into Cavity
C35236	Injury_to_Esophagus_with_Open_Wound_into_Cavity	Injury_to_Esophagus	Injury to Esophagus with Open Wound into Cavity
C35237	Gastrointestinal_Injury	Gastrointestinal_System_Finding|Injury	Gastrointestinal Injury
C35238	Injury_to_Stomach_with_Open_Wound_into_Cavity	Gastrointestinal_Injury	Injury to Stomach with Open Wound into Cavity
C35239	Injury_to_Duodenum_with_Open_Wound_into_Cavity	Gastrointestinal_Injury	Injury to Duodenum with Open Wound into Cavity
C35240	Injury_to_Rectum_with_Open_Wound_into_Cavity	Gastrointestinal_Injury	Injury to Rectum with Open Wound into Cavity
C35241	Injury_to_Liver	Gastrointestinal_Injury	Injury to Liver
C35242	Injury_to_Liver_without_mention_of_Open_Wound_into_Cavity	Injury_to_Liver	Injury to Liver without mention of Open Wound into Cavity
C35243	Injury_to_Liver_with_Open_Wound_into_Cavity	Injury_to_Liver	Injury to Liver with Open Wound into Cavity
C35244	Injury_to_Spleen_with_Open_Wound_into_Cavity	Abdominal_Injury	Injury to Spleen with Open Wound into Cavity
C35245	Injury_to_Kidney	Injury	Injury to Kidney
C35246	Injury_to_Kidney_without_mention_of_Open_Wound_into_Cavity	Injury_to_Kidney	Injury to Kidney without mention of Open Wound into Cavity
C35247	Injury_to_Kidney_with_Open_Wound_into_Cavity	Injury_to_Kidney	Injury to Kidney with Open Wound into Cavity
C35248	Injury_to_Peritoneum_without_mention_of_Open_Wound_into_Cavity	Injury_to_Peritoneum	Injury to Peritoneum without mention of Open Wound into Cavity
C35249	Injury_to_Peritoneum_with_Open_Wound_into_Cavity	Injury_to_Peritoneum	Injury to Peritoneum with Open Wound into Cavity
C35250	Injury_to_Retroperitoneum_with_Open_Wound_into_Cavity	Injury	Injury to Retroperitoneum with Open Wound into Cavity
C35251	Foreign_Body_in_Stomach	Foreign_Body_in_Gastrointestinal_Tract	Foreign Body in Stomach
C35252	Foreign_Body_in_Genitourinary_Tract	Foreign_Body	Foreign Body in Genitourinary Tract
C35253	Foreign_Body_in_Penis	Foreign_Body_in_Genitourinary_Tract	Foreign Body in Penis
C35254	Skin_Vascular_Disorder	Skin_Disorder|Vascular_Disorder	Skin Vascular Disorder
C35255	Greig_s_Syndrome	Syndrome	Greig's Syndrome
C35256	Aicardi_Syndrome	Syndrome	Aicardi Syndrome
C35257	Alper_s_Syndrome	Syndrome	Alper's Syndrome
C35259	Chondromatosis	Enchondroma	Chondromatosis
C35261	Congenital_Adrenal_Hypoplasia	Congenital_Adrenal_Gland_Disorder	Congenital Adrenal Gland Hypoplasia|Congenital Adrenal Hypoplasia
C35262	Hereditary_Sideroblastic_Anemia	Anemia	Hereditary Sideroblastic Anemia
C35263	Stress_Ulcer	Duodenal_Ulcer	Stress Ulcer|Curling Ulcer
C35264	Rapidly_Progressive_Glomerulonephritis	Glomerulonephritis	Rapidly Progressive Glomerulonephritis
C35265	Acanthosis	Morphologic_Finding	Acanthosis
C35266	Anisocytosis	Abnormal_Hematology_Test_Result	Anisocytosis
C35267	Poikilocytosis	Abnormal_Hematology_Test_Result	Poikilocytosis
C35268	Macrocephaly	Congenital_or_Acquired_Anatomic_Abnormality	Macrocephaly|Megacephaly|Megalocephaly
C35269	Simple_Type_Schizophrenia	Schizophrenia	Simple Type Schizophrenia
C35270	Chronic_Schizophrenia	Schizophrenia	Chronic Schizophrenia
C35271	Nontoxic_Goiter	Goiter	Nontoxic Goiter
C35272	Lower_Abdominal_Pain	Abdominal_Pain	Lower Abdominal Pain
C35273	Animal_Phobia	Phobia	Animal Phobia
C35274	Perception_Disturbance	Psychiatric_Disorder	Perception Disturbance
C35275	Visual_Cortex_Disorder	Vision_Disorder	Visual Cortex Disorder
C35276	Visual_Agnosia	Vision_Disorder	Visual Agnosia
C35277	Acneiform_Dermatitis	Dermatitis	Acneiform Dermatitis
C35278	Chemically_Induced_Neurotoxicity	Chemically_Induced_Toxicity	Chemically Induced Neurotoxicity
C35279	Vein_Disorder	Non-Neoplastic_Vascular_Disorder	Vein Disorder
C35280	Focal_Glomerulonephritis	Glomerulonephritis	Focal Glomerulonephritis
C35281	Proliferative_Glomerulonephritis	Glomerulonephritis	Proliferative Glomerulonephritis
C35282	Alpha_Fetoprotein_Increased	Abnormal_Blood_and_Hematology_Test_Result	Alpha Fetoprotein Increased
C35284	Specific_Phobia	Phobia	Specific Phobia
C35285	Foreign_Body_in_Bladder	Foreign_Body_in_Genitourinary_Tract	Foreign Body in Bladder
C35286	C_Difficile_Colitis	Clostridium_Colitis	C.Difficile Colitis
C35287	Hemoglobin_E_Disease	Hemoglobinopathy	Hemoglobin E Disease
C35288	Desquamative_Interstitial_Pneumonia	Idiopathic_Interstitial_Pneumonia	Desquamative Interstitial Pneumonia|DIP|RBILD|Respiratory Bronchiolitis Interstitial Lung Disease
C35289	Axillary_Mass	Mass	Axillary Mass
C35290	Mass_of_the_Back	Mass	Mass of the Back|Mass of Back
C35291	Buttock_Mass	Mass	Buttock Mass
C35292	Low-Grade_Fever	Fever	Low Grade Fever
C35293	Inguinal_Mass	Mass	Inguinal Mass
C35294	Hepatic_Mass	Mass	Hepatic Mass|Liver Mass
C35295	Mediastinal_Mass	Mass	Mediastinal Mass
C35296	Nose_Deformity	Congenital_or_Acquired_Anatomic_Abnormality	Nose Deformity
C35297	Skin_Burning_Sensation	Disturbance_of_Skin_Sensation	Skin Burning Sensation
C35298	Inferior_Vena_Cava_Occlusion	Vena_Cava_Occlusion	Inferior Vena Cava Occlusion
C35299	Hemolytic_Jaundice	Jaundice	Hemolytic Jaundice
C35300	Sheehan_s_Syndrome	Syndrome	Sheehan's Syndrome|Postpartum Hypopituitarism
C35301	Loffler_s_Syndrome	Eosinophilic_Pneumonia|Syndrome	Loffler's Syndrome
C35302	Viral_Encephalitis	Encephalitis	Viral Encephalitis
C35303	Anterolateral_Myocardial_Infarction	Myocardial_Infarction	Anterolateral Myocardial Infarction
C35304	Anteroseptal_Myocardial_Infarction	Myocardial_Infarction	Anteroseptal Myocardial Infarction
C35305	Subendocardial_Myocardial_Infarction	Myocardial_Infarction	Subendocardial Myocardial Infarction
C35306	Renal_Mass	Mass	Renal Mass|Kidney Mass
C35307	Axillary_Abscess	Abscess|Non-Neoplastic_Axillary_Disorder	Axillary Abscess
C35308	Allergic_Dermatitis_due_to_Arnica	Dermatitis	Allergic Dermatitis due to Arnica
C35309	Dermatitis_due_to_Acids	Dermatitis	Dermatitis due to Acids
C35310	Dermatitis_due_to_Alkalis	Dermatitis	Dermatitis due to Alkalis
C35311	Dermatitis_due_to_Dichromate	Dermatitis	Dermatitis due to Dichromate
C35312	Sun_Exposure_Dermatitis	Photosensitive_Dermatitis	Sun Exposure Dermatitis
C35313	Juvenile_Osteochondrosis	Osteochondrosis	Juvenile Osteochondrosis
C35314	Tracheal_Calcification	Metabolic_Disorder|Non-Neoplastic_Tracheal_Disorder	Tracheal Calcification
C35315	Kaolin_Pneumoconiosis	Pneumoconiosis	Kaolin Pneumoconiosis
C35316	Chemical_Pneumonitis	Pneumonia	Chemical Pneumonitis
C35317	Arterial_Disorder	Non-Neoplastic_Vascular_Disorder	Arterial Disorder|Arteriopathy
C35318	Arterial_Occlusion	Arterial_Disorder	Arterial Occlusion|Arterial Obstruction
C35319	Internal_Hemorrhoid	Hemorrhoid	Internal Hemorrhoid
C35320	External_Hemorrhoid	Hemorrhoid	External Hemorrhoid
C35321	Coffin-Siris_Syndrome	Syndrome	Coffin-Siris Syndrome
C35322	Phocomelia_of_the_Upper_Limb	Phocomelia	Phocomelia of the Upper Limb|Phocomelia of Upper Limb
C35323	Phocomelia_of_the_Lower_Limb	Phocomelia	Phocomelia of the Lower Limb|Phocomelia of Lower Limb
C35324	Congenital_Hallux_Valgus	Congenital_Abnormality|Hallux_Valgus	Congenital Hallux Valgus
C35325	Congenital_Kyphosis	Kyphosis	Congenital Kyphosis
C35326	Chronic_Periodontitis	Periodontitis	Chronic Periodontitis
C35327	Broncho-Esophageal_Fistula	Fistula	Broncho-Esophageal Fistula|Esophagobronchial Fistula
C35328	Injury_to_Esophagus	Gastrointestinal_Injury	Injury to Esophagus
C35329	Crohn_s_Ileitis	Crohn_s_Disease_of_Small_Intestine	Crohn's Ileitis
C35330	Eosinophilic_Gastroenteritis	Gastroenteritis	Eosinophilic Gastroenteritis
C35331	Acute_Hepatitis	Hepatitis	Acute Hepatitis
C35332	Cholecystitis_with_Cholelithiasis	Cholecystitis	Cholecystitis with Cholelithiasis
C35333	Cystic_Duct_Stone	Gallbladder_Stone	Cystic Duct Stone
C35334	Acute_Cholangitis	Cholangitis	Acute Cholangitis
C35335	Chronic_Cholangitis	Cholangitis	Chronic Cholangitis
C35336	Suppurative_Cholangitis	Cholangitis	Suppurative Cholangitis
C35337	Congenital_Nephrotic_Syndrome	Nephrotic_Syndrome	Congenital Nephrotic Syndrome
C35338	Renal_Vascular_Disorder	Non-Neoplastic_Vascular_Disorder	Renal Vascular Disorder
C35339	First_Degree_Uterine_Prolapse	Uterine_Prolapse	First Degree Uterine Prolapse
C35340	Second_Degree_Uterine_Prolapse	Uterine_Prolapse	Second Degree Uterine Prolapse
C35341	Partial_Retinal_Vein_Occlusion	Retinal_Vein_Occlusion	Partial Retinal Vein Occlusion
C35342	Visual_Pathway_Disorder	Vision_Disorder	Visual Pathway Disorder
C35343	Drug-Induced_Aplastic_Anemia	Aplastic_Anemia	Drug-Induced Aplastic Anemia
C35344	Hemoglobin_D_Disease	Hemoglobinopathy	Hemoglobin D Disease
C35345	Acquired_Factor_VIII_Deficiency	Acquired_Coagulation_Factor_Deficiency	Acquired Factor VIII Deficiency
C35346	Lymph_Node_Disorder	Hematopoietic_System_Disorder	Lymph Node Disorder
C35347	Splenic_Abscess	Abscess|Splenic_Disorder	Splenic Abscess
C35348	Ear_Injury	Eye_and_Ear_Finding|Injury	Ear Injury
C35349	Nose_Injury	Face_Injury	Nose Injury|Nose Trauma
C35350	Closed_Fracture_of_Rib	Rib_Fracture	Closed Fracture of Rib
C35351	Open_Fracture_of_Rib	Open_Fracture|Rib_Fracture	Open Fracture of Rib
C35352	Closed_Fracture_of_Pelvis	Closed_Fracture|Fracture_of_Pelvis	Closed Fracture of Pelvis
C35353	Open_Fracture_of_Pelvis	Fracture_of_Pelvis|Open_Fracture	Open Fracture of Pelvis
C35354	Fracture_of_Metacarpal_Bone	Upper_Extremity_Fracture	Fracture of Metacarpal Bone
C35355	Closed_Fracture_of_Shaft_of_Metacarpal_Bone	Closed_Fracture_of_Metacarpal_Bone	Closed Fracture of Shaft of Metacarpal Bone
C35356	Closed_Fracture_of_Neck_of_Metacarpal_Bone	Closed_Fracture_of_Metacarpal_Bone	Closed Fracture of Neck of Metacarpal Bone
C35357	Open_Fracture_of_Shaft_of_Metacarpal_Bone	Open_Fracture_of_Metacarpal_Bone	Open Fracture of Shaft of Metacarpal Bone
C35358	Open_Fracture_of_Neck_of_Metacarpal_Bone	Open_Fracture_of_Metacarpal_Bone	Open Fracture of Neck of Metacarpal Bone
C35359	Burn_of_Axilla	Burn	Burn of Axilla
C35360	Cytomegaloviral_Pneumonia	Viral_Respiratory_Tract_Infection	Cytomegaloviral Pneumonia
C35361	Cryptococcal_Pneumonia	Pneumonia	Cryptococcal Pneumonia
C35362	Bladder_Schistosomiasis	Genitourinary_System_Infection|Schistosomiasis	Bladder Schistosomiasis
C35363	Infection_by_Schistosoma_Bovis	Schistosomiasis	Infection by Schistosoma Bovis
C35364	Infection_by_Schistosoma_Intercalatum	Schistosomiasis	Infection by Schistosoma Intercalatum
C35365	Infection_by_Schistosoma_Mattheii	Schistosomiasis	Infection by Schistosoma Mattheii
C35366	Ancylostomiasis_due_to_Ancylostoma_Ceylanicum	Ancylostomiasis	Ancylostomiasis due to Ancylostoma Ceylanicum
C35367	Intermittent_Pyrexia	Fever	Intermittent Pyrexia|Intermittent Fever
C35369	Neurotic_Depression	Depression	Neurotic Depression
C35370	Bone_Marrow_Neoplasm	Bone_Marrow_Disorder|Hematopoietic_System_Neoplasm	Bone Marrow Neoplasm|Bone Marrow Tumor	Neoplasms that affect the bone marrow.  Such neoplasms may arise in the bone marrow (e.g. myeloid leukemias) or may involve the bone marrow as secondary, metastatic tumors (e.g. metastatic carcinomas to the bone marrow). --2003
C35371	Lytic_Metastatic_Lesion	Lytic_Lesion|Metastatic_Lesion	Lytic Metastatic Bone Lesion|Osteolytic Lesion
C35372	Ascending_Cholangitis	Cholangitis	Ascending Cholangitis
C35373	Zoonotic_Bacterial_Infection	Bacterial_Infection|Zoonotic_Infection	Zoonotic Bacterial Infection|Zoonotic Bacterial Disease
C35374	Viral_Gastroenteritis	Gastroenteritis	Viral Gastroenteritis
C35375	Crush_Injury	Injury	Crush Injury
C35376	Tracheal_Agenesis	Non-Neoplastic_Tracheal_Disorder	Tracheal Agenesis|Tracheal Absence
C35377	Congenital_Arteriovenous_Fistula	Arteriovenous_Fistula|Congenital_Abnormality	Congenital Arteriovenous Fistula
C35378	Epiphrenic_Diverticulum	Diverticulum	Epiphrenic Diverticulum|Pulsion Diverticulum
C35379	Hyaline_Cast_Formation	Cast_Formation	Hyaline Cast Formation
C35380	Hemorrhagic_Change	Morphologic_Finding	Hemorrhagic Change
C35381	Mallory_Body	Morphologic_Finding	Mallory Bodies Present
C35382	True_Histiocytic_Lymphoma	Hematopoietic_and_Lymphoid_Neoplasms_Antiquated	True Histiocytic Lymphoma
C35383	Acute_Necrotizing_Encephalitis	Viral_Encephalitis	Acute Necrotizing Encephalitis
C35384	Hallucinogen_Dependence_Continuous_Use	Hallucinogen_Dependence	Hallucinogen Dependence, Continuous Use
C35385	Hallucinogen_Dependence_Episodic_Use	Hallucinogen_Dependence	Hallucinogen Dependence, Episodic Use
C35386	Cannabis_Dependence_Continuous_Use	Cannabis_Dependence	Cannabis Dependence, Continuous Use
C35387	Cannabis_Dependence_Episodic_Use	Cannabis_Dependence	Cannabis Dependence, Episodic Use
C35388	Cocaine_Dependence_Continuous_Use	Cocaine_Dependence	Cocaine Dependence, Continuous Use
C35389	Cocaine_Dependence_Episodic_Use	Cocaine_Dependence	Cocaine Dependence, Episodic Use
C35390	Respiratory_Malfunction_Arising_from_Mental_Factor	Non-Neoplastic_Lung_Disorder|Psychosomatic_Disorder	Respiratory Malfunction Arising from Mental Factor
C35391	Conjuctival_Injury	Ocular_Injury	Conjunctival Injury
C35392	Corneal_Injury	Ocular_Injury	Corneal Injury
C35393	Congenital_Lens_Disorder	Lens_Disorder	Congenital Lens Disorder
C35394	Primary_Open_Angle_Glaucoma	Open_Angle_Glaucoma	Primary Open Angle Glaucoma
C35395	Laryngeal_Injury	Head_and_Neck_Finding|Injury	Laryngeal Injury|Laryngeal Trauma
C35396	Toxoplasma_Pneumonia	Pneumonia	Toxoplasma Pneumonia
C35397	Slate_Pneumoconiosis	Pneumoconiosis	Slate Pneumoconiosis
C35398	Inferior_Myocardial_Infarction	Myocardial_Infarction	Inferior Myocardial Infarction
C35399	Posterior_Myocardial_Infarction	Myocardial_Infarction	Posterior Myocardial Infarction
C35400	Silent_Myocardial_Infarction	Myocardial_Infarction	Silent Myocardial Infarction
C35401	Arterial_Injury	Cardiovascular_Injury	Arterial Injury
C35402	Cytomegalovirus_Colitis	Colitis	Cytomegalovirus Colitis|CMV Colitis
C35403	Appendix_Mass	Mass	Appendix Mass|Appendiceal Mass
C35404	Pancreatic_Duct_Stone	Gastrointestinal_System_Finding|Stone	Pancreatic Duct Stone
C35405	Trichomonas_Cystitis	Trichomonas_Infection	Trichomonas Cystitis
C35406	Trichomonas_Balanoposthitis	Trichomonas_Infection	Trichomonas Balanoposthitis
C35407	Diffuse_C-Cell_Hyperplasia	Hyperplasia	Diffuse C-Cell Hyperplasia
C35408	Adrenal_Gland_Hyperplasia	Hyperplasia	Adrenal Gland Hyperplasia
C35409	Adrenal_Mass	Mass	Adrenal Mass
C35410	Mite-Born_Hemorrhagic_Fever	Viral_Hemorrhagic_Fever	Mite-Born Hemorrhagic Fever
C35411	Tick-Born_Hemorrhagic_Fever	Viral_Hemorrhagic_Fever	Tick-Born Hemorrhagic Fever
C35412	Rodent-Born_Hemorrhagic_Fever	Viral_Hemorrhagic_Fever	Rodent-Born Hemorrhagic Fever
C35413	Flying_Phobia	Phobia	Flying Phobia
C35414	Granular_Cast_Formation	Cast_Formation	Granular Cast Formation
C35415	Vaginal_Hypoplasia	Congenital_Genitourinary_Abnormality	Vaginal Hypoplasia|Hypoplasia of Vagina
C35416	Mixed_Tumor_of_the_Parotid_Gland	Mixed_Tumor_of_the_Salivary_Gland|Parotid_Gland_Neoplasm	Mixed Tumor of the Parotid Gland|Mixed Tumor of Parotid Gland
C35417	Intrahepatic_Cholangiocarcinoma	Cholangiocarcinoma|Hepatic_Disorder|Liver_and_Intrahepatic_Biliary_Tract_Carcinoma|Primary_Malignant_Neoplasm_of_Liver	Intrahepatic Cholangiocarcinoma|ICC|Intrahepatic Bile Duct Carcinoma|Intrahepatic Carcinoma of Bile Duct|Intrahepatic Carcinoma of the Bile Duct|Intrahepatic Cholangiocellular Carcinoma|Peripheral Cholangiocarcinoma	(ko-LAN-jee-o-sar-KO-ma) A tumor of the connective tissues of the bile ducts.
C35418	Local_Tumor_Spread	Neoplastic_Growth_or_Spread	Local Tumor Spread|Local Tumour Spread
C35419	Lipoma_of_Axilla	Benign_Axillary_Neoplasm|Lipoma	Axillary Lipoma|Lipoma of Axilla
C35420	Phobia	Socialized_Conduct_Disorder	Phobia	anxiety disorder characterized by intense, unrealistic, persistent fear and avoidance of an object, activity, or situation.
C35421	Nonorganic_Insomnia	Insomnia	Nonorganic Insomnia
C35422	Anal_Injury	Gastrointestinal_Injury	Anal Injury
C35423	Complex_Endometrial_Hyperplasia	Endometrial_Hyperplasia	Complex Endometrial Hyperplasia
C35424	Richter_s_Syndrome	Syndrome	Richter's Syndrome	Transformation of chronic lymphocytic leukemia into aggressive non-Hodgkin's lymphoma, usually diffuse large B-cell lymphoma (immunoblastic or centroblastic variant).  Occasional cases of transformation to Hodgkin's lymphoma have also been described, particularly in patients treated with purine nucleotide analogues.  Molecular genetic studies suggest that in approximately half of the cases, the lymphoma is clonally related to the underlying chronic lymphocytic leukemia, whereas in the remaining cases the lymphoma probably represents a secondary, unrelated neoplasm. -- 2004
C35425	Splenic_Marginal_Zone_B-Cell_Lymphoma_with_Villous_Lymphocytes	Splenic_Marginal_Zone_Lymphoma	Splenic Marginal Zone B-Cell Lymphoma with Villous Lymphocytes|Splenic Lymphoma with Circulating Villous Lymphocytes	A B-cell non-Hodgkin's lymphoma composed of small lymphocytes which surround and replace the splenic white pulp germinal centers.  This entity was previously known as a splenic lymphoma with circulating villous lymphocytes, is rare, and involves the spleen and splenic hilar lymph nodes, bone marrow, and often the peripheral blood.  The patients present with splenomegaly and the clinical course is indolent.  (WHO, 2001) -- 2003
C35426	Examination_Phobia	Phobia	Examination Phobia
C35427	Malignant_neoplasms_of_multiple_primary_sites	Malignant_Neoplasm	Malignant Neoplasms of Multiple Primary Sites
C35428	Epithelial_Cast_Formation	Cast_Formation	Epithelial Cast Formation
C35429	Fatty_Cast_Formation	Cast_Formation	Fatty Cast Formation
C35430	Waxy_Cast_Formation	Cast_Formation	Waxy Cast Formation
C35431	Acute_Gonococcal_Infection_of_Upper_Genitourinary_Tract	Gonococcal_Infection_of_Genitourinary_Tract	Acute Gonococcal Infection of Upper Genitourinary Tract
C35432	Acute_Endocarditis	Endocarditis	Acute Endocarditis
C35433	Adrenogenital_Syndrome	Syndrome	Adrenogenital Syndrome
C35434	Polycythaemia_due_to_Excess_Erythropoetin_Production	Secondary_Polycythemia	Polycythaemia due to Excess Erythropoetin Production
C35435	Enlarging_Abdomen	Symptom	Enlarging Abdomen
C35436	Cauda_Equina_Syndrome	Non-Neoplastic_Peripheral_Nervous_System_Disorder|Syndrome	Cauda Equina Syndrome
C35437	Familiar_Idiopathic_Dystonia	Familiar_Dystonia|Idiopathic_Torsion_Dystonia	Familiar Idiopathic Dystonia
C35438	Non-familiar_Idiopathic_Dystonia	Idiopathic_Torsion_Dystonia	Non-familiar Idiopathic Dystonia
C35439	Hemophagocytic_Syndrome	Syndrome	Hemophagocytic Syndrome
C35440	Acquired_Factor_IX_Deficiency	Acquired_Coagulation_Factor_Deficiency	Acquired Factor IX Deficiency
C35441	Cerebral_Sarcoidosis	Sarcoidosis	Cerebral Sarcoidosis
C35442	Hepatic_Vascular_Disorder	Hepatic_Disorder|Vascular_Disorder	Hepatic Vascular Disorder
C35443	Post-Streptococcal_Glomerulonephritis	Glomerulonephritis	Post-Streptococcal Glomerulonephritis
C35444	Crescentic_Glomerulonephritis	Glomerulonephritis	Crescentic Glomerulonephritis
C35445	Mesangial_Proliferative_Glomerulonephritis	Glomerulonephritis	Mesangial Proliferative Glomerulonephritis
C35446	Bladder_Injury	Injury	Bladder Injury
C35447	Avascular_Necrosis_of_Femoral_Head	Avascular_Necrosis_of_Femur	Avascular Necrosis of Femoral Head
C35448	Eye_Discharge	Fluid_Discharge	Eye Discharge
C35449	Negative_Sickling_Test	Negative_Test_Result	Negative Sickling Test
C35450	Negative_Pregnancy_Test	Negative_Test_Result	Negative Pregnancy Test
C35451	Electrocardiogram_QRS_Complex_Shortened	Electrocardiographic_Finding	Electrocardiogram QRS Complex Shortened
C35452	Urethral_Meatus_Stenosis	Non-Neoplastic_Urethra_Disorder	Urethral Meatus Stenosis|Meatal Stenosis
C35453	Bronchial_Injury	Injury	Bronchial Injury
C35454	Injury_to_Diaphragm	Injury	Injury to Diaphragm
C35455	Gallbladder_Injury	Gastrointestinal_Injury	Gallbladder Injury
C35456	Colon_Injury	Gastrointestinal_Injury	Colon Injury
C35457	Abnormal_Urine_Test_Result	Abnormal_Laboratory_Test	Abnormal Urine Test Result
C35458	Dependence	Behavior-Related_Disorder	Dependence
C35459	Chemical_Injury	Injury	Chemical Injury
C35460	Crystal_Formation	Deposit	Crystal Formation|Crystal Deposition
C35461	Clinical_Course_of_Disease	Finding	Clinical Course of Disease
C35462	Left_Ventricular_Mass	Mass	Left Ventricular Mass|LV Mass
C35463	Simple_Endometrial_Hyperplasia	Endometrial_Hyperplasia	Simple Endometrial Hyperplasia
C35464	Granulomatous_Slack_Skin_Disease	Mycosis_Fungoides_Variant	Granulomatous Slack Skin Disease	A rare variant of mycosis fungoides, characterized by the development of folds of lax skin in the axillae or groins.  It has been reported in association with Hodgkin's lymphoma.  Morphologically, there is a dense granulomatous dermal atypical lymphocytic infiltrate, often associated with multinucleated giant cells.  Destruction of elastic tissue is present.  Most cases have an indolent clinical course. -- 2005
C35465	Aplastic_Anemia_due_to_Radiation	Aplastic_Anemia	Aplastic Anemia due to Radiation
C35466	Aplastic_Anemia_due_to_Infection	Aplastic_Anemia	Aplastic Anemia due to Infection
C35467	Achenbach_Syndrome	Syndrome	Achenbach Syndrome
C35468	Macular_Edema	Non-Neoplastic_Retinal_Disorder	Macular Edema
C35469	Anemia_due_to_Disorder_of_Nucleotide_Metabolism	Anemia	Anemia due to Disorder of Nucleotide Metabolism
C35470	Behavior-Related_Disorder	Diseases_and_Disorders	Behavior-Related Disorder|Behavior-Related Problem|Behavioral Disorder|Behaviour-Related Disorder|Lifestyle-Related Condition|Lifestyle-Related Disorder|Lifestyle-Related Problem
C35471	Nucleated_Red_Blood_Cell_Present	Abnormal_Hematology_Test_Result	Nucleated Red Blood Cells Present
C35472	Anemia_due_to_Enzyme_Disorder	Anemia	Anemia due to Enzyme Disorder
C35473	Acute_Renal_Failure_with_Renal_Papillary_Necrosis	Acute_Renal_Failure	Acute Renal Failure with Renal Papillary Necrosis
C35474	Lower_Leg_Injury	Leg_Injury	Lower Leg Injury
C35475	Tooth_Abscess	Abscess|Non-Neoplastic_Dental_Disorder	Tooth Abscess
C35476	Aseptic_Necrosis_of_Bone	Bone_Necrosis	Aseptic Necrosis of Bone
C35477	Renal_Arteriovenous_Malformation	Arteriovenous_Malformation	Renal Arteriovenous Malformation
C35478	Congenital_Macular_Corneal_Dystrophy	Macular_Corneal_Dystrophy	Congenital Macular Corneal Dystrophy
C35479	Retinal_Arteriovenous_Malformation	Arteriovenous_Malformation	Retinal Arteriovenous Malformation
C35480	Aseptic_Necrosis_of_Femoral_Head	Aseptic_Necrosis_of_Head_and_Neck_of_Femur	Aseptic Necrosis of Femoral Head|Aseptic Necrosis of Head of Femur
C35481	Atrial_Tachycardia	Supraventricular_Tachycardia	Atrial Tachycardia
C35482	Alveolitis	Pneumonia	Alveolitis
C35483	Bacterial_Gastroenteritis	Gastroenteritis	Bacterial Gastroenteritis
C35484	Cardiovascular_Injury	Cardiovascular_System_Finding|Injury	Cardiovascular Injury	damage inflicted on any part of cardiovascular system as the direct or indirect result of an external force, with or without disruption of structural continuity.
C35485	Gingival_Injury	Head_and_Neck_Finding|Injury	Gingival Injury
C35486	Lower_Back_Injury	Back_Injury	Lower Back Injury
C35487	Bone_Injury	Injury	Bone Injury
C35488	Injury_to_Peritoneum	Abdominal_Injury	Injury to Peritoneum
C35489	Thoracic_Spine_Kyphosis	Kyphosis	Thoracic Spine Kyphosis
C35490	Esophageal_Mass	Mass	Esophageal Mass|Oesophageal Mass
C35491	Stomach_Mass	Abdominal_Mass	Stomach Mass|Gastric Mass|Mass of Stomach|Mass of the Stomach
C35492	Cancerphobia	Phobia	Cancerphobia
C35493	Axillary_Lymphadenopathy	Lymphadenopathy	Axillary Lymphadenopathy|Axillary Adenopathy
C35494	Epigastric_Mass	Abdominal_Mass	Epigastric Mass
C35495	Hilar_Mass	Pulmonary_Mass	Hilar Mass|Pulmonary Hilum Mass
C35496	Chemically_Induced_Cytotoxicity	Chemically_Induced_Toxicity	Chemically Induced Cytotoxicity	The adverse effect of some iatrogenic therapies. It is an accepted side effect in radiation therapy where the desired effect is to kill rapidly growing tumor cells.  In the killing of tumor cells, other cells that are rapidly growing e.g hair, mucous membranes are also killed.
C35497	Lymph_Node_Neoplasm	Hematopoietic_System_Neoplasm|Lymph_Node_Disorder	Lymph Node Neoplasm
C35498	Toxic_Shock_Syndrome	Syndrome	Toxic Shock Syndrome	syndrome characterized by high fever, vomiting, diarrhea, confusion, and skin rash; almost all cases have been related to an infection with toxin-producing Staphylococcus aureus.
C35499	Vascular_Purpura	Non-Neoplastic_Vascular_Disorder	Vascular Purpura
C35500	Chemically_Induced_Toxicity	Biological_Effect_of_Chemicals	Chemically Induced Toxicity
C35501	Malignant_Bone_Marrow_Neoplasm	Bone_Marrow_Neoplasm	Malignant Bone Marrow Neoplasm|Malignant Bone Marrow Tumor	Malignant neoplasms that either originate from the bone marrow (e.g. myeloid leukemias) or involve the bone marrow as secondary-metastatic tumors (e.g. metastatic carcinomas to the bone marrow).  --2003
C35503	Gastrointestinal_Infection	Abdominal_and_Gastrointestinal_Infection|Non-Neoplastic_Gastrointestinal_Disorder	Gastrointestinal Infection
C35504	Vascular_Proliferation	Vascular_Morphologic_Change	Vascular Proliferation
C35505	Coronary_Atherosclerosis	Atherosclerosis	Coronary Atherosclerosis
C35506	Throat_Cancer	Neck_Carcinoma	Throat Cancer|Throat Carcinoma	Carcinoma, predominantly squamous cell, arising from epithelial cells of the larynx or pharynx. -- 2004
C35507	Axillary_Lymph_Node_Involvement	Lymph_Node_Involvement	Axillary Lymph Node Involvement
C35508	Abnormal_Bone_Marrow_Test_Result	Abnormal_Hematology_Test_Result	Abnormal Bone Marrow Test Result
C35509	Brain_Mass	Mass	Brain Mass
C35510	Endobronchial_Mass	Pulmonary_Mass	Endobronchial Mass
C35511	Endocervical_Mass	Mass	Endocervical Mass
C35512	Limb_Injury	Injury	Limb Injury
C35513	Avascular_Necrosis_of_Femur	Avascular_Necrosis_of_Bone	Avascular Necrosis of Femur
C35514	Flank_Mass	Mass	Flank Mass
C35515	Gastrointestinal_Arteriovenous_Malformation	Arteriovenous_Malformation	Gastrointestinal Arteriovenous Malformation
C35516	Gastrointestinal_Polyp	Gastrointestinal_Disorder|Polyp	Gastrointestinal Polyp|GI Polyp
C35517	Avascular_Necrosis_of_Humerus	Avascular_Necrosis_of_Bone	Avascular Necrosis of Humerus
C35518	Lumbar_Spine_Kyphosis	Kyphosis	Lumbar Spine Kyphosis
C35519	Septal_Myocardial_Infarction	Myocardial_Infarction	Septal Myocardial Infarction
C35520	Nasal_Mass	Mass	Nasal Mass|Mass of Nose|Mass of the Nose
C35521	Lymph_Node_Mass	Mass	Lymph Node Mass|Nodal Mass
C35522	Periodontal_Infection	Dental_and_Periodontal_Infection	Periodontal Infection
C35523	Vaginal_Abscess	Abscess	Vaginal Abscess
C35524	White_Blood_Cell_Count_Increased	Abnormal_Hematology_Test_Result	White Blood Cell Count Increased|WBC Increased
C35525	Hemolytic_Anemia_due_to_Disseminated_Intravascular_Coagulation	Acquired_Hemolytic_Anemia	Hemolytic Anemia due to Disseminated Intravascular Coagulation
C35526	Chronic_Insomnia	Insomnia	Chronic Insomnia
C35527	Familiar_Dystonia	Dystonia	Familiar Dystonia
C35528	Wolf-Hirschhorn_Syndrome	Syndrome	Wolf-Hirschhorn Syndrome|4p Deletion Syndrome
C35529	Lymph_Node_Involvement	Hematopoietic_System_Finding	Lymph Node Involvement
C35530	Thrombocytosis	Abnormal_Hematology_Test_Result	Thrombocytosis
C35531	Pulmonary_Vascular_Disorder	Non-Neoplastic_Lung_Disorder|Vascular_Disorder	Pulmonary Vascular Disorder
C35532	Portal_Cirrhosis	Cirrhosis	Portal Cirrhosis
C35533	Nephrotic_Syndrome_with_Lesion_of_Focal_Glomerulosclerosis	Nephrotic_Syndrome	Nephrotic Syndrome with Lesion of Focal Glomerulosclerosis
C35534	Nephrotic_Syndrome_with_Lesion_of_Segmental_Hyalinosis	Nephrotic_Syndrome	Nephrotic Syndrome with Lesion of Segmental Hyalinosis
C35535	Nephrotic_Syndrome_with_Lesion_of_Endothelial_Glomerulonephritis	Nephrotic_Syndrome	Nephrotic Syndrome with Lesion of Endothelial Glomerulonephritis
C35536	Nephrotic_Syndrome_with_Lesion_of_Hypocomplementemic_Glomerulonephritis	Nephrotic_Syndrome	Nephrotic Syndrome with Lesion of Hypocomplementemic Glomerulonephritis
C35537	Nephrotic_Syndrome_with_Lesion_of_Persistent_Glomerulonephritis	Nephrotic_Syndrome	Nephrotic Syndrome with Lesion of Persistent Glomerulonephritis
C35538	Nephrotic_Syndrome_with_Lesion_of_Lobular_Glomerulonephritis	Nephrotic_Syndrome	Nephrotic Syndrome with Lesion of Lobular Glomerulonephritis
C35539	Nephrotic_Syndrome_with_Lesion_of_Mesangiocapillary_Glomerulonephritis	Nephrotic_Syndrome	Nephrotic Syndrome with Lesion of Mesangiocapillary Glomerulonephritis
C35540	Nephrotic_Syndrome_with_Lesion_of_Minimal_Change_Glomerulonephritis	Nephrotic_Syndrome	Nephrotic Syndrome with Lesion of Minimal Change Glomerulonephritis
C35541	Hyperkeratosis	Morphologic_Finding	Hyperkeratosis
C35542	Traumatic_Encephalopathy	Encephalopathy	Traumatic Encephalopathy	damage inflicted to the bra; may be acute or chronic.
C35543	Arteriolosclerosis	Arteriosclerosis	Arteriolosclerosis
C35544	Myocardial_Disorder	Non-Neoplastic_Heart_Disorder	Myocardial Disorder
C35545	Acroosteolysis	Non-Neoplastic_Bone_Disorder	Acroosteolysis
C35546	Dysphasia	Nervous_System_Finding|Symptom	Dysphasia
C35547	Yellow_Fever_Virus_Infection	Viral_Infection	Yellow Fever Virus Infection
C35548	Monoclonal_Gammopathy	Abnormal_Blood_and_Hematology_Test_Result	Monoclonal Gammopathy
C35549	Hypoxic_Encephalopathy	Encephalopathy	Hypoxic Encephalopathy|Anoxic encephalopathy
C35550	Acute_Poliomyelitis	Central_Nervous_System_Infectious_Disorder	Acute Poliomyelitis
C35552	Cardiovascular_System_Finding	Finding_by_Site_or_System	Cardiovascular System Finding	Patient complaints (symptoms), physical/laboratory findings(signs) related to the cardiovascular system.
C35553	Abnormal_Blood_and_Hematology_Test_Result	Abnormal_Laboratory_Test	Abnormal Blood and Hematology Test Result
C35555	Salivary_Gland_Sebaceous_Lymphadenoma	Salivary_Gland_Monomorphic_Adenoma	Salivary Gland Sebaceous Lymphadenoma|Sebaceous Lymphadenoma of Salivary Gland|Sebaceous Lymphadenoma of the Salivary Gland	A rare benign epithelial tumor composed of irregular, proliferating nests and islands of epithelium, including solid and gland-like sebaceous elements, surrounded by lymphoid stroma. Most occur in the parotid gland. Symptoms include a progressively enlarging, painless mass.  Sebaceous lymphadenocarcinoma is the malignant counterpart. -- 2003
C35556	Childhood_Botryoid-Type_Embryonal_Rhabdomyosarcoma_of_the_Vagina	Botryoid-Type_Embryonal_Rhabdomyosarcoma_of_the_Vagina|Childhood_Botryoid-Type_Embryonal_Rhabdomyosarcoma	Childhood Botryoid-Type Embryonal Rhabdomyosarcoma of the Vagina|Childhood Sarcoma Botryoides of the Vagina|Vaginal Childhood Botryoid-Type Embryonal Rhabdomyosarcoma|Vaginal Childhood Sarcoma Botryoides
C35557	Metastatic_Malignant_Neoplasm_to_the_Cervix	Retired_Concepts	Metastatic Malignant Neoplasm to the Cervix|Metastatic Malignant Neoplasm to the Uterine Cervix|Metastatic Malignant Tumor to the Cervix|Metastatic Malignant Tumor to the Uterine Cervix
C35558	Tall_Cell_Variant_Papillary_Carcinoma	Papillary_Thyroid_Carcinoma	Tall Cell Variant Thyroid Gland Papillary Carcinoma|Tall Cell Variant Papillary Carcinoma	A morphologic variant of papillary carcinoma of the thyroid gland characterized by the presence of tall malignant follicular cells, arranged in papillary and trabecular patterns.  Necrotic changes, and high mitotic activity are present. (NCI05)
C35560	Complex_Endometrial_Hyperplasia_with_Atypia	Atypical_Endometrial_Hyperplasia|Complex_Endometrial_Hyperplasia	Complex Endometrial Hyperplasia with Atypia	A hyperplasia characterized by excessive proliferation of endometrial cells, resulting in the formation of complex epithelial structures.  It is associated with cytologic atypia and an increased risk of endometrial adenocarcinoma. --2004
C35561	Rare_Cancer-associated_Syndrome	Rare_Disorder	Rare Cancer-Associated Syndrome
C35562	Neuroepithelial_Perineurial_and_Schwann_Cell_Neoplasm	Neoplasm_by_Morphology|Nervous_System_Neoplasm	Neuroepithelial, Perineurial, and Schwann Cell Neoplasm|Neural Neoplasm|Neural Tumor	A morphologic category that includes neoplasms arising from cells that form and support the nervous system.  Such neoplasms include neuroepithelial cell neoplasms and neoplasms that arise from the perineural sheaths (perineurial cell neoplasms and Schwann cell neoplasms). --2003
C35566	Atypical_Lymphocytes_Present	Abnormal_Hematology_Test_Result	Atypical Lymphocytes Present
C35567	Hurthle_Cell_Metaplasia	Metaplasia	Hurthle Cell Metaplasia
C35568	Astler-Coller_B1_Colon_Carcinoma	Astler-Coller_B1_Colorectal_Carcinoma|Colon_Cancer_by_Astler-Coller_Stage	Astler-Coller B1 Colon Carcinoma
C35569	Chemically_Induced_Cardiotoxicity	Chemically_Induced_Toxicity	Chemically Induced Cardiotoxicity|Chemically Induced Cardiac Toxicity|Toxicity, Chemically Induced Cardiac
C35570	Chemically_Induced_Urinary_Tract_Toxicity	Chemically_Induced_Toxicity	Chemically Induced Urinary Tract Toxicity|Toxicity, Chemically Induced Urinary Tract
C35571	Progressive_Disease	Clinical_Course_of_Disease	Progressive Disease|PD|progressive disease	Cancer that is increasing in scope or severity.
C35574	Childhood_Botryoid-Type_Embryonal_Rhabdomyosarcoma	Botryoid-Type_Embryonal_Rhabdomyosarcoma|Childhood_Embryonal_Rhabdomyosarcoma	Childhood Botryoid-Type Embryonal Rhabdomyosarcoma|Childhood Botryoid Rhabdomyosarcoma|Childhood Sarcoma Botryoides
C35575	Chemically_Induced_Irreversible_Toxicity	Chemically_Induced_Toxicity	Chemically Induced Irreversible Toxicity
C35576	Mucocutaneous_Candidiasis	Candidiasis	Mucocutaneous Candidiasis
C35577	Traumatic_Hemorrhage	Hemorrhage	Traumatic Hemorrhage
C35578	Acalculous_Cholecystitis	Cholecystitis	Acalculous Cholecystitis
C35579	Acute_Acalculous_Cholecystitis	Acalculous_Cholecystitis|Acute_Cholecystitis	Acute Acalculous Cholecystitis
C35580	Hemorrhagic_Complication_of_Pregnancy	Pregnancy_Complication	Hemorrhagic Complication of Pregnancy
C35581	Initial_Insomnia	Insomnia	Initial Insomnia
C35582	Middle_Insomnia	Insomnia	Middle Insomnia
C35583	Low_Frequency_Deafness	Deafness	Low Frequency Deafness
C35584	Erythrophagocytosis	Hemophagocytosis	Erythrophagocytosis|Erythrocytophagy|Erythrophagia	Erythrophagocytosis; phagocytosis of erythrocytes.
C35585	Mixed_Stone	Stone	Mixed Stone
C35586	Lateral_Myocardial_Infarction	Myocardial_Infarction	Lateral Myocardial Infarction
C35587	Acute_Diffuse_Glomerulonephritis	Acute_Glomerulonephritis|Diffuse_Glomerulonephritis	Acute Diffuse Glomerulonephritis
C35588	Trichomonas_Cervicitis	Trichomonas_Infection	Trichomonas Cervicitis
C35589	Cardiac_Sarcoidosis	Non-Neoplastic_Heart_Disorder|Sarcoidosis	Cardiac Sarcoidosis
C35590	Cryptococcal_Gastroenteritis	Viral_Gastroenteritis	Cryptococcal Gastroenteritis
C35591	Cryptosporidial_Gastroenteritis	Viral_Gastroenteritis	Cryptosporidial Gastroenteritis
C35592	Emphysematous_Cholecystitis	Cholecystitis	Emphysematous Cholecystitis
C35593	Congenital_Spondylolysis	Spondylolysis	Congenital Spondylolysis
C35594	Maternal_Complication_of_Pregnancy	Pregnancy_Complication	Maternal Complication of Pregnancy
C35595	Vascular_Hemorrhagic_Disorder	Non-Neoplastic_Vascular_Disorder	Vascular Hemorrhagic Disorder
C35596	Dental_Developmental_Disorder	Non-Neoplastic_Dental_Disorder	Dental Developmental Disorder
C35597	Dental_Surface_Disorder	Dental_Disorder	Dental Surface Disorder
C35598	Dental_Pain_and_Sensation_Disorder	Dental_Disorder	Dental Pain and Sensation Disorder
C35599	Congenital_Adrenal_Gland_Disorder	Non-Neoplastic_Adrenal_Gland_Disorder|Non-Neoplastic_Endocrine_Disorder	Congenital Adrenal Gland Disorder
C35600	Skin_Ischemic_Condition	Skin_Vascular_Disorder	Skin Ischemic Condition
C35601	Visual_Field_Disorder	Vision_Disorder	Visual Field Disorder
C35602	Chronic_Metabolic_Polyneuropathy	Chronic_Polyneuropathy	Chronic Metabolic Polyneuropathy
C35603	Chronic_Toxic_Polyneuropathy	Chronic_Polyneuropathy	Chronic Toxic Polyneuropathy
C35604	Sleep_Disorder_due_to_General_Medical_Condition	Sleep_Disorder	Sleep Disorder due to General Medical Condition
C35605	Glomerular_Vascular_Disorder	Renal_Disorder|Vascular_Disorder	Glomerular Vascular Disorder
C35606	Cartilage_Injury	Injury	Cartilage Injury
C35607	Blood_Alkaline_Phosphatase_Increased	Abnormal_Blood_and_Hematology_Test_Result	Blood Alkaline Phosphatase Increased
C35608	Aggravated_Colitis	Colitis	Aggravated Colitis
C35609	Exacerbated_Insomnia	Insomnia	Exacerbated Insomnia
C35610	Diabetic_Vascular_Disorder	Non-Neoplastic_Vascular_Disorder	Diabetic Vascular Disorder
C35611	Hepatic_Arteriovenous_Malformation	Arteriovenous_Malformation	Hepatic Arteriovenous Malformation
C35613	Negative_Schumm_s_Test	Negative_Test_Result	Negative Schumm's Test
C35614	AIDS_Phobia	Phobia	AIDS Phobia
C35615	Sputum_Excretion_Difficulty	Symptom	Sputum Excretion Difficulty
C35616	Papillary_Conjunctivitis	Conjunctivitis	Papillary Conjunctivitis
C35617	Post_Abortion_Hemorrhage	Hemorrhage|Reproductive_System_Finding	Post Abortion Hemorrhage
C35618	Iris_Vascular_Disorder	Iris_Disorder|Ocular_Vascular_Disorder	Iris Vascular Disorder
C35619	Herpes_Zoster_Dermatitis	Dermatitis|Skin_Infection	Herpes Zoster Dermatitis
C35620	Herpes_Simplex_Dermatitis	Dermatitis|Skin_Infection	Herpes Simplex Dermatitis
C35621	Gonococcal_Infection_of_Genitourinary_Tract	Genitourinary_System_Infection|Gonococcal_Infection	Gonococcal Infection of Genitourinary Tract
C35622	Caustic_Injury	Injury	Caustic Injury
C35623	Aortic_Injury	Cardiovascular_Injury	Aortic Injury
C35624	Enterovirus_Gastroenteritis	Viral_Gastroenteritis	Enterovirus Gastroenteritis
C35625	Retinal_Dystrophy	Non-Neoplastic_Retinal_Disorder	Retinal Dystrophy
C35626	Spinal_Vascular_Disorder	Vascular_Disorder	Spinal Vascular Disorder
C35627	Negative_Skin_Test	Negative_Test_Result	Negative Skin Test
C35628	Criminal_Injury	Injury	Criminal Injury
C35629	Submandibular_Duct_Stone	Salivary_Duct_Stone	Submandibular Duct Stone
C35630	Domestic_Injury	Injury	Domestic Injury
C35631	Periapical_Dental_Abscess	Tooth_Abscess	Periapical Dental Abscess
C35632	Fredrickson_Type_I_Lipidemia	Hyperlipidemia	Fredrickson Type I Lipidemia
C35633	Negative_Patch_Test	Negative_Test_Result	Negative Patch Test
C35634	C_Sordelli_Colitis	Clostridium_Colitis	C.Sordelli Colitis
C35635	Chronic_Candidiasis	Candidiasis	Chronic Candidiasis
C35636	Lower_Ribs_Pain	Bone_Pain	Lower Ribs Pain
C35637	Type_IIb_Hyperlipidemia	Type_II_Hyperlipidemia	Type IIb Hyperlipidemia
C35638	Increased_Sputum_Excretion	Symptom	Increased Sputum Excretion
C35639	Femoral_Hernia_with_Obstruction_without_mention_of_Gangrene	Femoral_Hernia_with_Obstruction|Hernia_with_Obstruction_without_mention_of_Gangrene	Femoral Hernia with Obstruction without mention of Gangrene
C35640	Umbilical_Hernia_with_Obstruction_without_mention_of_Gangrene	Hernia_with_Obstruction_without_mention_of_Gangrene	Umbilical Hernia with Obstruction without mention of Gangrene
C35641	Hernia_with_Obstruction_without_mention_of_Gangrene	Hernia	Hernia with Obstruction without mention of Gangrene
C35642	Ventral_Hernia_with_Obstruction_without_mention_of_Gangrene	Hernia_with_Obstruction_without_mention_of_Gangrene	Ventral Hernia with Obstruction without mention of Gangrene
C35643	Corrosive_Injury	Injury	Corrosive Injury
C35644	Fredrickson_Type_III_Lipidemia	Hyperlipidemia	Fredrickson Type III Lipidemia
C35645	Fredrickson_Type_V_Lipidemia	Hyperlipidemia	Fredrickson Type V Lipidemia|Type V Lipidemia
C35646	Pancreatic_Injury	Abdominal_Injury|Gastrointestinal_System_Finding	Pancreatic Injury|Pancreatic Trauma
C35647	Insomnia_due_to_Organic_Factor	Insomnia	Insomnia due to Organic Factor
C35648	Non-Resectable_Primary_Hepatic_Malignant_Neoplasm	Hepatic_Disorder|Hepatic_and_Intrahepatic_Bile_Duct_Neoplasm	Non-Resectable Hepatic Malignant Neoplasm|Non-Resectable Malignant Neoplasm of Liver
C35649	Hydroxyproline_Urine_Increased	Abnormal_Urine_Test_Result	Hydroxyproline Urine Increased
C35650	Upper_Respiratory_Tract_Infection	Infectious_Lung_Disorder	Upper Respiratory Tract Infection|Upper Respiratory Tract Inflammation
C35651	Post-Procedural_Pain	Pain	Post-Procedural Pain
C35652	Acquired_Macrocephaly	Macrocephaly	Acquired Macrocephaly|Acquired Megacephaly|Acquired Megalocephaly
C35653	Congenital_Macrocephaly	Congenital_Abnormality|Macrocephaly	Congenital Macrocephaly|Congenital Megacephaly|Congenital Megalocephaly
C35654	Carcinomatous_Ascites	Malignant_Ascites	Carcinomatous Ascites
C35655	Normal_Blood_Test_Result	Normal_Laboratory_Test_Result	Normal Blood Test Result
C35656	Post_Procedural_Hemorrhage	Hemorrhage	Post Procedural Hemorrhage
C35657	Normal_Phenolsulfonphthalein_Test	Normal_Blood_Test_Result	Normal Phenolsulfonphthalein Test|Normal PSP Test
C35658	Congenital_Dental_Disorder	Non-Neoplastic_Dental_Disorder	Congenital Dental Disorder
C35659	Anemia_due_to_Chronic_Disorder	Anemia	Anemia due to Chronic Disorder
C35660	Cytomegalovirus_Gastroenteritis	Viral_Gastroenteritis	Cytomegalovirus Gastroenteritis|CMV Gastroenteritis
C35661	Chest_Wall_Cyst	Cyst	Chest Wall Cyst
C35662	Tumor_Associated_Fever	Fever	Tumor Associated Fever|Tumor-Associated Fever
C35663	Injury_Asphyxation	Injury	Injury Asphyxation
C35664	Ocular_Vascular_Disorder	Eye_Disorder|Vascular_Disorder	Ocular Vascular Disorder
C35665	Neutropenic_Fever	Fever	Neutropenic Fever|Febrile Neutropenia
C35666	Ureter_Abscess	Abscess	Ureter Abscess|Pyoureter
C35667	Post-biopsy_Pain	Pain	Post-biopsy Pain
C35668	Non-Proliferative_Diabetic_Retinopathy	Diabetic_Retinopathy	Non-Proliferative Diabetic Retinopathy
C35669	Abdominal_Infection	Abdominal_and_Gastrointestinal_Infection	Abdominal Infection
C35670	Phobia_of_Driving	Phobia	Phobia of Driving
C35671	Bursa_Injury	Injury	Bursa Injury
C35672	Posterolateral_Myocardial_Infarction	Myocardial_Infarction	Posterolateral Myocardial Infarction
C35673	Inferolateral_Myocardial_Infarction	Myocardial_Infarction	Inferolateral Myocardial Infarction|Inferolateral Myocardial Infarct
C35674	Astler-Coller_B2_Colon_Carcinoma	Astler-Coller_B2_Colorectal_Carcinoma|Colon_Cancer_by_Astler-Coller_Stage	Astler-Coller B2 Colon Carcinoma
C35675	Recurrent_Malignant_Neoplasm_of_Salivary_Gland	Malignant_Salivary_Gland_Neoplasm	Recurrent Malignant Neoplasm of Salivary Gland	The reemergence of salivary gland cancer after a period of remission
C35676	Localized_Malignant_Gallbladder_Neoplasm	Malignant_Gallbladder_Neoplasm	Localized Malignant Gallbladder Neoplasm|Malignant Neoplasm of Gallbladder Localized
C35681	Negative_Test_Result	Test_Result	Negative Test Result|negative test result	A test result that fails to show the specific disease or condition for which the test was being done.
C35682	Positive_Test_Result	Test_Result	Positive Test Result|positive test result	A test result confirming the presence of a disease, condition, or microorganism. (NCI)
C35684	Localized_Pagetoid_Reticulosis	Retired_Concepts	Localized Pagetoid Reticulosis|Woringer-Kolopp Disease	This is a localized form of pagetoid reticulosis with an excellent prognosis.  --2003
C35685	Mycosis_Fungoides-Associated_Follicular_Mucinosis	Mycosis_Fungoides_Variant	Folliculotropic Mycosis Fungoides|Follicular Mycosis Fungoides|Mycosis Fungoides-Associated Follicular Mucinosis	A rare variant of mycosis fungoides, characterized by cerebriform lymphocytic infiltration of the hair follicles of the head and neck.  Most cases show mucinous degeneration of the hair follicles, and are designated as mycosis fungoides-associated follicular mucinosis.  Cases without mucinous degeneration have been reported as pilotropic mycosis fungoides.  There is no difference in clinical presentation or outcome between mycosis fungoides-associated follicular mucinosis and pilotropic mycosis fungoides.  In the recent WHO-EORTC classification, folliculotropic mycosis fungoides is the preferred term for all cases.
C35686	Immunodeficiency-Related_Disorder	Immune_System_and_Related_Disorders	Immunodeficiency-Related Disorder|Immunodepression-Related Disorder|Immunosuppression-Related Disorder
C35687	Parotid_Gland_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue|Parotid_Gland_Non-Hodgkin_s_Lymphoma	Parotid Gland Mucosa-Associated Lymphoid Tissue Lymphoma|Parotid Gland MALT lymphoma
C35688	Breast_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue|Primary_Non-Hodgkin_s_Breast_Lymphoma	Breast Mucosa-Associated Lymphoid Tissue Lymphoma|Breast MALT lymphoma
C35689	Ocular_Adnexae_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue|Eye_Lymphoma	Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma|Ocular Adnexal MALT lymphoma
C35690	Eye_Lymphoma	Lymphoma_by_Site|Malignant_Eye_Neoplasm	Eye Lymphoma|Primary Eye Lymphoma
C35691	Mixed_Tumor_of_the_Salivary_Gland	Mixed_Neoplasm	Mixed Tumor of the Salivary Gland|Mixed Tumor of Salivary Gland
C35692	Posterior_Pharyngeal_Wall_Carcinoma	Pharyngeal_Carcinoma	Posterior Pharyngeal Wall Carcinoma
C35693	Posterior_Pharyngeal_Wall_Squamous_Cell_Carcinoma	Head_and_Neck_Squamous_Cell_Carcinoma|Posterior_Pharyngeal_Wall_Carcinoma	Posterior Pharyngeal Wall Squamous Cell Carcinoma
C35694	Stage_IVA_Major_Salivary_Gland_Carcinoma	Stage_IV_Major_Salivary_Gland_Carcinoma	Stage IVA Major Salivary Gland Carcinoma|Stage IVA Major Salivary Gland Cancer|Stage IVA Salivary Gland Cancer
C35695	Stage_IVB_Major_Salivary_Gland_Carcinoma	Stage_IV_Major_Salivary_Gland_Carcinoma	Stage IVB Major Salivary Gland Carcinoma|Stage IVB Major Salivary Gland Cancer|Stage IVB Salivary Gland Cancer
C35696	Stage_IVC_Major_Salivary_Gland_Carcinoma	Stage_IV_Major_Salivary_Gland_Carcinoma	Stage IVC Major Salivary Gland Carcinoma|Stage IVC Major Salivary Gland Cancer|Stage IVC Salivary Gland Cancer
C35697	Epiglottic_Carcinoma	Malignant_Epiglottis_Neoplasm|Supraglottic_Carcinoma	Epiglottic Carcinoma|Epiglottic Cancer
C35698	Benign_Uvula_Neoplasm	Benign_Soft_Palate_Neoplasm	Benign Uvula Neoplasm|Benign Uvula Tumor|Benign Uvula Tumour|Benign Uvular Neoplasm|Benign Uvular Tumor
C35699	Diffuse_Infiltrative_Lymphocytosis_Syndrome	Syndrome	Diffuse Infiltrative Lymphocytosis Syndrome	This is usually an oligoclonal CD8+ lymphocytic infiltration of various organs.
C35700	Salivary_Gland_Myoepithelial_Carcinoma	Myoepithelial_Carcinoma|Salivary_Gland_Carcinoma|Salivary_Gland_Myoepithelial_Neoplasm	Salivary Gland Myoepithelial Carcinoma
C35701	Salivary_Gland_Epithelial_Myoepithelial_Carcinoma	Epithelial-Myoepithelial_Carcinoma|Salivary_Gland_Adenocarcinoma	Salivary Gland Epithelial Myoepithelial Carcinoma
C35702	Salivary_Gland_Polymorphous_Low-Grade_Adenocarcinoma	Salivary_Gland_Adenocarcinoma	Salivary Gland Polymorphous Low Grade Adenocarcinoma|Salivary Gland Terminal Duct Adenocarcinoma
C35703	Salivary_Gland_Anaplastic_Small_Cell_Carcinoma	Salivary_Gland_Carcinoma|Small_Cell_Carcinoma	Salivary Gland Anaplastic Small Cell Carcinoma|Anaplastic Small Cell Carcinoma of Salivary Gland|Anaplastic Small Cell Carcinoma of the Salivary Gland|Neuroendocrine Carcinoma of Salivary Gland|Neuroendocrine Carcinoma of the Salivary Gland|Salivary Gland Neuroendocrine Carcinoma
C35704	Acute_Contagious_Conjunctivitis	Acute_Conjunctivitis	Acute Contagious Conjunctivitis|Pinkeye
C35705	Closed_Dislocation	Dislocation	Closed Dislocation
C35706	Exudative_Glomerulonephritis	Glomerulonephritis	Exudative Glomerulonephritis
C35707	Focal_Embolic_Glomerulonephritis	Glomerulonephritis	Focal Embolic Glomerulonephritis
C35708	Stone	Other_Finding	Stone|Calculus
C35709	Aagenaes_Syndrome	Syndrome	Aagenaes Syndrome
C35710	Allgrove_Syndrome	Syndrome	Allgrove Syndrome
C35711	Testicular_Teratoma_with_Somatic-Type_Malignancy	Malignant_Testicular_Non-Seminomatous_Germ_Cell_Tumor|Teratoma_with_Malignant_Transformation|Testicular_Teratoma	Testicular Teratoma with Somatic-Type Malignancy|Testicular Teratoma with Non-Germ Cell Malignancy	This is a new term that will be included in the upcoming 2003 edition of the WHO classification of testicular tumors.  Previously, testicular teratomas were classified as mature, immature, and "with malignant transformation".  WHO '03 reorganizes the classification into two categories: teratoma and teratoma with somatic-type malignancy (possibly "non-germ cell malignancy").  It is clear by now that teratomas (both mature and immature) in postpubertal patients can be associated with metastases.  In contrast, teratomas (both mature and immature) in prepubertal patients are always benign (from the 2003 International Society of Urological Pathology companion meeting syllabus-annual meeting of the United States and Canadian Academy of Pathology).--2002
C35712	Follicular_Bronchitis_Bronchiolitis	Benign_Lymphoproliferative_Disorder|Non-Neoplastic_Lung_Disorder	Follicular Bronchitis/Bronchiolitis|Follicular Hyperplasia of BALT|Pulmonary Lymphoid Hyperplasia
C35713	Nodular_Lymphoid_Hyperplasia_of_Lung	Benign_Lymphoproliferative_Disorder|Non-Neoplastic_Lung_Disorder	Nodular Lymphoid Hyperplasia of Lung
C35714	Idiopathic_Interstitial_Pneumonia	Interstitial_Pneumonitis	Idiopathic Interstitial Pneumonia
C35715	Usual_Interstitial_Pneumonia	Idiopathic_Interstitial_Pneumonia	Usual Interstitial Pneumonia|UIP
C35716	Idiopathic_Pulmonary_Fibrosis	Pulmonary_Fibrosis	Idiopathic Pulmonary Fibrosis|IPF
C35717	Nonspecific_Interstitial_Pneumonia	Idiopathic_Interstitial_Pneumonia	Nonspecific Interstitial Pneumonia|NSIP
C35718	Undifferentiated_Thymic_Carcinoma	Thymoma_Type_C|Undifferentiated_Carcinoma	Thymic Undifferentiated Carcinoma	A rare primary thymic carcinoma, characterized by an undifferentiated solid tumor growth, without associated sarcomatoid features. -- 2005
C35719	Genitourinary_System_Infection	Infectious_Disorder_by_Site	Genitourinary System Infection
C35720	Trichomonas_Infection	Genitourinary_System_Infection|Protozoal_Infection	Trichomonas Infection
C35721	Paraphrenia	Psychiatric_Disorder	Paraphrenia
C35722	Third_Degree_Uterine_Prolapse	Uterine_Prolapse	Third Degree Uterine Prolapse
C35723	Nasopharyngeal_Disorder	Pharyngeal_Disorder	Nasopharyngeal Disorder
C35724	Dislocation	Injury	Dislocation
C35725	Grade_II_Neuroendocrine_Carcinoma	Neoplasm_by_Obsolete_Classification	Grade II Neuroendocrine Carcinoma
C35726	Grade_III_Neuroendocrine_Carcinoma	Neoplasm_by_Obsolete_Classification	Grade III Neuroendocrine Carcinoma
C35727	Grade_I_Neuroendocrine_Carcinoma	Neoplasm_by_Obsolete_Classification	Grade I Neuroendocrine Carcinoma
C35728	Congenital_Cardiovascular_Disorder	Non-Neoplastic_Cardiovascular_Disorder	Congenital Cardiovascular Disorder
C35729	Congenital_Cardiovascular_Abnormality	Congenital_Abnormality	Congenital Cardiovascular Abnormality|Congenital Cardiovascular Anomaly
C35730	Gonococcal_Infection	Bacterial_Infection	Gonococcal Infection
C35731	Hearing_Loss	Hearing_Disorder	Hearing Loss
C35732	High_Frequency_Deafness	Deafness	High Frequency Deafness
C35733	Head_and_Neck_Infection	Infectious_Disorder_by_Site	Head and Neck Infection
C35734	Small_Cell_Undifferentiated_Salivary_Gland_Carcinoma	Undifferentiated_Salivary_Gland_Carcinoma	Small Cell Undifferentiated Salivary Gland Carcinoma
C35735	Large_Cell_Undifferentiated_Salivary_Gland_Carcinoma	Undifferentiated_Salivary_Gland_Carcinoma	Large Cell Undifferentiated Salivary Gland Carcinoma
C35736	Lymphoepithelial_Salivary_Gland_Carcinoma	Undifferentiated_Salivary_Gland_Carcinoma	Lymphoepithelial Salivary Gland Carcinoma
C35737	Salivary_Gland_Adenosquamous_Carcinoma	Adenosquamous_Carcinoma|Salivary_Gland_Carcinoma	Salivary Gland Adenosquamous Carcinoma
C35738	Salivary_Gland_Sebaceous_Adenoma	Salivary_Gland_Monomorphic_Adenoma|Sebaceous_Adenoma	Salivary Gland Sebaceous Adenoma	A rare, benign, encapsulated epithelial tumor composed of cells that form solid, variably shaped islands and cysts, both showing focal sebaceous differentiation. The mean age of patients is reported to be 58 years, and most tumors occur in the parotid gland. There is a male predominance. Most patients are asymptomatic. -- 2003
C35739	Skin_Appendage_Sebaceous_Adenoma	Sebaceous_Adenoma|Skin_Appendage_Adenoma	Skin Appendage Sebaceous Adenoma
C35740	Non-Neoplastic_Vascular_Disorder	Non-Neoplastic_Cardiovascular_Disorder|Vascular_Disorder	Non-Neoplastic Vascular Disorder
C35741	Non-Neoplastic_Heart_Disorder	Heart_Disease|Non-Neoplastic_Cardiovascular_Disorder|Non-Neoplastic_Thoracic_Disorder	Non-Neoplastic Heart Disorder
C35742	Thoracic_Disorder	Respiratory_and_Thoracic_Disorder	Thoracic Disorder|Thoracic Disease
C35743	Non-Neoplastic_Thoracic_Disorder	Thoracic_Disorder	Non-Neoplastic Thoracic Disorder|Non-Neoplastic Thoracic Disease
C35744	Sternal_Disorder	Thoracic_Disorder	Sternal Disorder
C35745	Chest_Wall_Disorder	Thoracic_Disorder	Chest Wall Disorder|Chest Wall Disease
C35746	Axillary_Disorder	Thoracic_Disorder	Axillary Disorder|Axillary Disease
C35747	Non-Neoplastic_Axillary_Disorder	Axillary_Disorder|Non-Neoplastic_Thoracic_Disorder	Non-Neoplastic Axillary Disorder
C35748	Metastatic_Malignant_Neoplasm_to_the_Axilla	Axillary_Neoplasm|Malignant_Thoracic_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Axilla|Axillary Metastases|Axillary Metastasis|Metastatic Malignant Tumor to the Axilla
C35749	Axillary_Neoplasm	Axillary_Disorder|Thoracic_Neoplasm	Axillary Neoplasm
C35750	Benign_Axillary_Neoplasm	Axillary_Neoplasm|Benign_Thoracic_Neoplasm	Benign Axillary Neoplasm
C35751	Non-Neoplastic_Sternal_Disorder	Non-Neoplastic_Thoracic_Disorder|Sternal_Disorder	Non-Neoplastic Sternal Disorder
C35752	Non-Neoplastic_Chest_Wall_Disorder	Chest_Wall_Disorder|Non-Neoplastic_Thoracic_Disorder	Non-Neoplastic Chest Wall Disorder
C35753	Non-Neoplastic_Tracheal_Disorder	Non-Neoplastic_Respiratory_Disorder|Tracheal_Disorder	Non-Neoplastic Tracheal Disorder|Non-Neoplastic Tracheal Disease
C35754	Tracheal_Atresia	Non-Neoplastic_Tracheal_Disorder	Tracheal Atresia
C35755	Non-Neoplastic_Respiratory_Disorder	Respiratory_Disorder	Non-Neoplastic Respiratory Disorder|Non-Neoplastic Respiratory Disease
C35756	Stage_IIIB_Small_Cell_Lung_Carcinoma_with_Pleural_Effusion	Extensive_Stage_Small_Cell_Lung_Carcinoma|Stage_IIIB_Small_Cell_Lung_Carcinoma	Stage IIIB Small Cell Lung Carcinoma with Pleural Effusion|Stage IIIB Small Cell Cancer of Lung with Pleural Effusion|Stage IIIB Small Cell Cancer of the Lung with Pleural Effusion|Stage IIIB Small Cell Carcinoma of Lung with Pleural Effusion|Stage IIIB Small Cell Carcinoma of the Lung with Pleural Effusion|Stage IIIB Small Cell Lung Cancer with Pleural Effusion
C35757	Stage_IIIB_Small_Cell_Lung_Carcinoma_without_Pleural_Effusion	Limited_Stage_Small_Cell_Lung_Carcinoma|Stage_IIIB_Small_Cell_Lung_Carcinoma	Stage IIIB Small Cell Lung Carcinoma without Pleural Effusion|Stage IIIB Small Cell Cancer of Lung without Pleural Effusion|Stage IIIB Small Cell Cancer of the Lung without Pleural Effusion|Stage IIIB Small Cell Carcinoma of Lung without Pleural Effusion|Stage IIIB Small Cell Carcinoma of the Lung without Pleural Effusion|Stage IIIB Small Cell Lung Cancer without Pleural Effusion
C35758	Stage_0_Large_Cell_Lung_Carcinoma	Large_Cell_Lung_Carcinoma|Stage_0_Non-Small_Cell_Lung_Cancer	Stage 0 Large Cell Lung Carcinoma|Stage 0 Large Cell Carcinoma of Lung|Stage 0 Large Cell Carcinoma of the Lung|Stage 0 Large Cell Lung Cancer
C35759	Metastasizing_Mixed_Tumor_of_the_Salivary_Gland	Metastatic_Benign_Neoplasm|Mixed_Tumor_of_the_Salivary_Gland	Metastasizing Mixed Tumor of the Salivary Gland|Metastasizing Mixed Tumor of Salivary Gland
C35760	Arthropathy	Non-Neoplastic_Bone_Disorder	Arthropathy|Joint Disorder
C35761	Transient_Arthropathy	Arthropathy	Transient Arthropathy
C35762	Traumatic_Arthropathy	Arthropathy	Traumatic Arthropathy
C35763	Traumatic_Arthritis	Arthritis|Traumatic_Arthropathy	Traumatic Arthritis
C35764	Wernicke-Korsakoff_Syndrome	Syndrome	Wernicke-Korsakoff Syndrome|Amnestic Syndrome
C35765	Histiocytoma	Fibrohistiocytic_Neoplasm	Histiocytoma	A benign or malignant mesenchymal tumor composed of fibroblastic and histiocytic cells. -- 2004
C35766	Normal_Laboratory_Test_Result	Lab_Finding	Normal Laboratory Test Result|Normal Lab Test Result
C35767	Generalized_Atherosclerosis	Atherosclerosis|Generalized_Arteriosclerosis	Generalized Atherosclerosis
C35768	Atherosclerosis	Arteriosclerosis	Atherosclerosis
C35769	Generalized_Arteriosclerosis	Arteriosclerosis	Generalized Arteriosclerosis
C35770	Monckeberg_Arteriosclerosis	Arteriosclerosis	Monckeberg Arteriosclerosis
C35771	Atherosclerotic_Cardiovascular_Disease	Arteriosclerotic_Cardiovascular_Disease	Atherosclerotic Cardiovascular Disease
C35772	Vitamin_Deficiency_Disorder	Nutritional_Disorder	Vitamin Deficiency Disorder
C35773	Bile_Duct_Stone	Gastrointestinal_System_Finding|Stone	Bile Duct Stone|Bile Duct Calculus
C35774	Non-Neoplastic_Biliary_Tract_Disorder	Biliary_Tract_Disorder	Non-Neoplastic Biliary Tract Disorder
C35775	Ciliary_Body_Disorder	Uveal_Disorder	Ciliary Body Disorder|Ciliary Body Disease
C35776	Non-Neoplastic_Uveal_Disorder	Non-Neoplastic_Eye_Disorder|Uveal_Disorder	Non-Neoplastic Uveal Disorder
C35777	Pediculosis_Pubis	Skin_Infection	Pediculosis Pubis|Phthiriasis
C35778	Gastrointestinal_Stromal_Tumor_of_the_Gastrointestinal_Tract	Gastrointestinal_Neoplasm|Gastrointestinal_Stromal_Tumor	Gastrointestinal Stromal Tumor of the Gastrointestinal Tract|Digestive Stromal Neoplasm|Digestive Stromal Tumor|Digestive Tract Stromal Neoplasm|Digestive Tract Stromal Tumor|Gastrointestinal Stromal Tumor of Gastrointestinal Tract|Gastrointestinal Tract Stromal Neoplasm|Gastrointestinal Tract Stromal Tumor|Stromal Neoplasm of Digestive Tract|Stromal Neoplasm of Gastrointestinal Tract|Stromal Neoplasm of the Digestive Tract|Stromal Neoplasm of the Gastrointestinal Tract|Stromal Tumor of Digestive Tract|Stromal Tumor of Gastrointestinal Tract|Stromal Tumor of the Digestive Tract|Stromal Tumor of the Gastrointestinal Tract
C35779	Non-Neoplastic_Dental_Disorder	Dental_Disorder|Non-Neoplastic_Oral_Cavity_Disorder	Non-Neoplastic Dental Disorder
C35780	Epitheliod_Cell_Uveal_Melanoma	Epithelioid_Cell_Melanoma|Uveal_Melanoma	Epitheliod Cell Uveal Melanoma|Uveal Epithelioid Cell Melanoma
C35781	Mixed_Cell_Uveal_Melanoma	Uveal_Melanoma	Mixed Cell Uveal Melanoma
C35782	Choroid_Mixed_Cell_Melanoma	Choroid_Melanoma|Mixed_Cell_Uveal_Melanoma	Choroid Mixed Cell Melanoma
C35783	Ciliary_Body_Mixed_Cell_Melanoma	Ciliary_Body_Melanoma|Mixed_Cell_Uveal_Melanoma	Ciliary Body Mixed Cell Melanoma
C35784	Non-Neoplastic_Hair_Disorder	Hair_Disorder|Non-Neoplastic_Skin_Disorder	Non-Neoplastic Hair Disorder
C35785	Muscle_Soreness	Connective_and_Soft_Tissue_Finding|Symptom	Muscle Soreness
C35786	Interstitial_Myocarditis	Myocarditis	Interstitial Myocarditis
C35787	Unstable_Personality	Socialized_Conduct_Disorder	Unstable Personality
C35788	Hypercellular_Bone_Marrow	Abnormal_Bone_Marrow_Test_Result	Hypercellular Bone Marrow
C35789	Lower_Thigh_Pain	Leg_Pain	Lower Thigh Pain
C35790	Congenital_Alopecia	Alopecia	Congenital Alopecia
C35791	Passive-Aggressive_Behavior	Socialized_Conduct_Disorder	Passive-Aggressive Behavior
C35792	Xanthogranulomatous_Cholecystitis	Cholecystitis	Xanthogranulomatous Cholecystitis
C35793	Femoropopliteal_Occlusive_Disease	Arterial_Occlusion	Femoropopliteal Occlusive Disease
C35794	Pagetoid_Reticulosis	Localized_Lymphoma|Mycosis_Fungoides_Variant	Pagetoid Reticulosis	A variant of mycosis fungoides, characterized by an exclusively intraepidermal atypical (cerebriform) lymphocytic infiltrate.  Patients present with a localized psoriasiform or hyperkeratotic patch or plaque, usually in the extremities.  Extracutaneous dissemination of the disease has never been reported.
C35795	Acrofacial_Dysostosis	Dysostosis	Acrofacial Dysostosis
C35796	Acute_Hemorrhagic_Encephalitis	Viral_Encephalitis	Acute Hemorrhagic Encephalitis
C35797	Demyelinating_Encephalopathy	Demyelinating_Disorder_of_Central_Nervous_System	Demyelinating Encephalopathy
C35798	Anti-Basement_Membrane_Glomerulonephritis	Glomerulonephritis	Anti-Basement Membrane Glomerulonephritis
C35799	Diffuse_Glomerulonephritis	Glomerulonephritis	Diffuse Glomerulonephritis
C35800	Immune_Complex_Glomerulonephritis	Glomerulonephritis	Immune Complex Glomerulonephritis
C35801	Subacute_Glomerulonephritis	Glomerulonephritis	Subacute Glomerulonephritis
C35802	Postpartum_Hypertension	Hypertension	Postpartum Hypertension
C35803	Zoonotic_Infection	Infectious_Disorder	Zoonotic Infection
C35804	Conditioned_Insomnia	Insomnia	Conditioned Insomnia
C35805	Ancylostomiasis	Parasitic_Infection	Ancylostomiasis
C35806	Acute_Interstitial_Pneumonia	Idiopathic_Interstitial_Pneumonia	Acute Interstitial Pneumonia|AIP|Acute Interstitial Pneumonitis
C35807	Hypercalcemic_Sarcoidosis	Sarcoidosis	Hypercalcemic Sarcoidosis
C35808	Abstinence_Syndrome	Syndrome	Abstinence Syndrome
C35809	Achard_Syndrome	Syndrome	Achard Syndrome
C35810	Acroparesthesia_Syndrome	Syndrome	Acroparesthesia Syndrome
C35811	Adherence_Syndrome	Syndrome	Adherence Syndrome
C35812	Malignant_Lymph_Node_Neoplasm	Lymph_Node_Neoplasm	Malignant Lymph Node Neoplasm|Lymph Node Cancer	A primary or metastatic malignant tumor involving the lymph node.  Lymphomas and metastatic carcinomas are representative examples. -- 2004
C35813	Hematopoietic_System_Neoplasm	Hematopoietic_System_Disorder|Neoplasm_by_Site	Hematopoietic and Lymphoid System Neoplasm|Hematopoietic and Lymphoid System Tumor	Neoplasms of the hematopoietic system, including hematopoietic cell neoplasms (e.g. leukemias, lymphomas) and non-hematopoietic cell neoplasms that can affect the hematopoietic system (e.g. lymph node and splenic sarcomas).  --2003
C35814	Hematopoietic_System_Disorder	Disorder_by_Site	Hematopoietic and Lymphoid System Disorder|Hematopoietic and Lymphoid System Disease
C35815	Granulocytic_Sarcoma	Myeloid_Sarcoma	Granulocytic Sarcoma	A tumor mass composed of myeloblasts, neutrophils and neutrophil precursors.  Granulocytic sarcoma is the most common type of myeloid sarcoma.  (WHO, 2001) -- 2003
C35816	Monoblastic_Sarcoma	Myeloid_Sarcoma	Monoblastic Sarcoma	A less common form of myeloid sarcoma composed of monoblasts.  Monoblastic sarcoma may precede or occur simultaneously with acute monoblastic leukemia. (WHO 2001). --2003
C35817	Blastic_Granulocytic_Sarcoma	Granulocytic_Sarcoma	Blastic Granulocytic Sarcoma	A granulocytic sarcoma composed primarily of myeloblasts (WHO 2001). --2003
C35818	Immature_Granulocytic_Sarcoma	Granulocytic_Sarcoma	Immature Granulocytic Sarcoma	A granulocytic sarcoma composed of myeloblasts and promyelocytes (WHO 2001). --2003
C35819	Differentiated_Granulocytic_Sarcoma	Granulocytic_Sarcoma	Differentiated Granulocytic Sarcoma	A granulocytic sarcoma composed of promyelocytes and more mature neutrophils (WHO 2001). --2003
C35820	Reticulin_Fibrosis_of_the_Bone_Marrow	Bone_Marrow_Fibrosis	Reticulin Fibrosis of the Bone Marrow
C35821	Collagen_Fibrosis_of_the_Bone_Marrow	Bone_Marrow_Fibrosis	Collagen Fibrosis of the Bone Marrow
C35822	Perivascular_Fibrosis	Fibrosis	Perivascular Fibrosis
C35823	Splenic_Disorder	Hematopoietic_System_Disorder	Splenic Disorder
C35824	Amputation_Neuroma	Traumatic_Neuroma	Amputation Neuroma
C35825	Megaloblastic_Erythroid_Hyperplasia	Erythroid_Hyperplasia	Megaloblastic Erythroid Hyperplasia
C35826	Foveolar_Hyperplasia	Hyperplasia	Foveolar Hyperplasia
C35827	Riedel_s_Fibrosing_Thyroiditis	Thyroiditis	Riedel's Fibrosing Thyroiditis
C35828	Subacute_Granulomatous_Thyroiditis	Subacute_Thyroiditis	Subacute Granulomatous Thyroiditis|De Quervain's Thyroiditis
C35829	Subacute_Lymphocytic_Thyroiditis	Lymphocytic_Thyroiditis|Subacute_Thyroiditis	Subacute Lymphocytic Thyroiditis
C35830	Columnar_Cell_Variant_Papillary_Carcinoma	Papillary_Thyroid_Carcinoma	Columnar Cell Variant Thyroid Gland Papillary Carcinoma|Columnar Cell Variant Papillary Carcinoma|Columnar Cell Variant Papillary Thyroid Gland Carcinoma	A morphologic variant of papillary carcinoma of the thyroid gland characterized by the presence of pseudostratified malignant follicular cells. (NCI05)
C35831	Carcinosarcoma_of_the_Salivary_Gland	Carcinosarcoma|Malignant_Mixed_Tumor_of_the_Salivary_Gland	Carcinosarcoma of the Salivary Gland|Carcinosarcoma of Salivary Gland
C35832	Parotid_Gland_Carcinosarcoma	Carcinosarcoma_of_the_Salivary_Gland|Malignant_Parotid_Gland_Mixed_Tumor	Parotid Gland Carcinosarcoma
C35833	Salivary_Gland_Cystadenoma	Benign_Salivary_Gland_Neoplasm	Salivary Gland Cystadenoma	An uncommon benign epithelial tumor, characterized by predominantly unicystic or multicystic growth; there is focal intraluminal papillary proliferation of the lining epithelium. Nearly half occur in the parotid gland.  In the minor salivary glands, women are affected more than men. In the major salivary glands, cystadenomas present as slowly enlarging, asymptomatic masses that may be slightly compressible. Cystadenocarcinoma is the malignant counterpart. -- 2003
C35834	Salivary_Gland_Intraductal_Papilloma	Intraductal_Papilloma|Salivary_Gland_Ductal_Papilloma	Salivary Gland Intraductal Papilloma	An intraluminal papillary proliferation that causes unicystic dilatation of the duct and may have features in common with papillary cystadenoma. It is quite rare, and involves almost exclusively the excretory ducts of intraoral minor salivary glands. It presents as an asymptomatic submucosal swelling. -- 2003
C35835	Salivary_Gland_Inverted_Ductal_Papilloma	Inverted_Papilloma|Salivary_Gland_Ductal_Papilloma	Salivary Gland Inverted Ductal Papilloma	A very rare benign tumor of the minor salivary glands, characterized by a luminal papillary proliferation that arises at the junction of the salivary gland duct and the oral mucosal surface epithelium and expands as a nodular mass into the lamina propria.  It presents as an asymptomatic mucosal swelling. -- 2003
C35836	Salivary_Gland_Sialadenoma_Papilliferum	Salivary_Gland_Ductal_Papilloma	Salivary Gland Sialadenoma Papilliferum	An uncommon exophytic papillary proliferation that involves mucosal surface epithelium and salivary duct epithelium. It is exceptional among salivary gland neoplasms because it manifests as an exophytic papillary excrescence of the mucosa, rather than as a submucosal or intraglandular mass. It most often affects the hard or soft palate.  It is generally asymptomatic. -- 2003
C35837	Salivary_Gland_Sialoblastoma	Salivary_Gland_Neoplasm	Salivary Gland Sialoblastoma	A rare, congenital or perinatal, aggressive and potentially low-grade malignant, basaloid neoplasm that occurs in the major salivary glands. It typically presents as a mass over the angle of the mandible. Most involve the parotid gland. -- 2003
C35838	Adrenal_Medullary_Hyperplasia	Adrenal_Gland_Hyperplasia	Adrenal Medullary Hyperplasia
C35839	Salivary_Gland_Ductal_Papilloma	Benign_Salivary_Gland_Neoplasm	Salivary Gland Ductal Papilloma
C35840	Intraepithelial_Melanocytic_Hyperplasia	Hyperplasia	Intraepithelial Melanocytic Hyperplasia|Benign Acquired Melanosis
C35841	Melanocytic_Dysplasia	Dysplasia	Melanocytic Dysplasia
C35842	Microaneurysm	Aneurysm	Microaneurysm|Charcot-Bouchard Aneurysm
C35843	Traumatic_Aneurysm	Aneurysm	Traumatic Aneurysm|False Aneurysm|Pseudoaneurysm
C35844	Radiation-Induced_Vascular_Disease	Radiation-Induced_Abnormalities	Radiation-Induced Vascular Disease
C35845	Basal_Cell_Hyperplasia	Hyperplasia	Basal Cell Hyperplasia
C35846	Columnar_Metaplasia	Glandular_Metaplasia	Columnar Metaplasia
C35847	Liver_Cell_Dysplasia	Dysplasia	Liver Cell Dysplasia|LCD
C35848	Large_Liver_Cell_Dysplasia	Liver_Cell_Dysplasia	Large Liver Cell Dysplasia
C35849	Small_Liver_Cell_Dysplasia	Liver_Cell_Dysplasia	Small Liver Cell Dysplasia
C35850	Head_and_Neck_Carcinoma	Carcinoma|Malignant_Head_and_Neck_Neoplasm	Head and Neck Carcinoma|Carcinoma of Head and Neck|Carcinoma of the Head and Neck
C35851	Grade_1_Conventional_Clear_Cell_Renal_Cell_Carcinoma	Conventional_Clear_Cell_Renal_Cell_Carcinoma	Grade 1 Conventional (Clear Cell) Renal Cell Carcinoma
C35852	Grade_2_Conventional_Clear_Cell_Renal_Cell_Carcinoma	Conventional_Clear_Cell_Renal_Cell_Carcinoma	Grade 2 Conventional (Clear Cell) Renal Cell Carcinoma
C35853	Grade_3_Conventional_Clear_Cell_Renal_Cell_Carcinoma	Conventional_Clear_Cell_Renal_Cell_Carcinoma	Grade 3 Conventional (Clear Cell) Renal Cell Carcinoma
C35854	Grade_4_Conventional_Clear_Cell_Renal_Cell_Carcinoma	Conventional_Clear_Cell_Renal_Cell_Carcinoma	Grade 4 Conventional (Clear Cell) Renal Cell Carcinoma
C35855	Squamous_Hyperplasia	Hyperplasia	Squamous Hyperplasia
C35856	Mesonephric_Hyperplasia	Hyperplasia	Mesonephric Hyperplasia
C35857	Stromal_Hyperplasia	Hyperplasia	Stromal Hyperplasia
C35858	Stromal_Metaplasia	Metaplasia	Stromal Metaplasia
C35859	Osseous_Metaplasia	Metaplasia	Osseous Metaplasia|Bone Metaplasia
C35860	Cartilagenous_Metaplasia	Metaplasia	Cartilagenous Metaplasia
C35861	Mesothelial_Hyperplasia	Hyperplasia	Mesothelial Hyperplasia
C35862	Adrenal_Pheochromocytoma	Retired_Concepts	Adrenal Gland Pheochromocytoma|Adrenal Medullary Paraganglioma|Adrenal Medullary Pheochromocytoma|Adrenal Pheochromocytoma|Chromaffin Neoplasm|Chromaffin Paraganglioma|Chromaffin Tumor|Chromaffinoma|Intraadrenal Paraganglioma	A pheochromocytoma occurring in the adrenal gland (which is the typical site of pheochromocytomas). -- 2004
C35863	Malignant_Adrenal_Pheochromocytoma	Retired_Concepts	Malignant Adrenal Gland Pheochromocytoma|Malignant Adrenal Medullary Paraganglioma|Malignant Adrenal Medullary Pheochromocytoma|Malignant Adrenal Pheochromocytoma|Malignant Chromaffin Neoplasm|Malignant Chromaffin Paraganglioma|Malignant Chromaffin Tumor|Malignant Chromaffinoma
C35864	Extra-Adrenal_Pheochromocytoma	Retired_Concepts	Extra-Adrenal Pheochromocytoma|Extraadrenal Pheochromocytoma
C35865	Malignant_Extra-Adrenal_Pheochromocytoma	Retired_Concepts	Malignant Extra-Adrenal Pheochromocytoma|Malignant Extraadrenal Pheochromocytoma
C35866	Normal_Urine_Test_Result	Normal_Laboratory_Test_Result	Normal Urine Test Result
C35867	Morphologic_Finding	Finding	Morphologic Finding
C35868	Maxillary_Sinus_Cholesteatoma	Cholesteatoma|Non-Neoplastic_Paranasal_Sinus_Disorder	Maxillary Sinus Cholesteatoma
C35869	Radiologic_Finding	Test_Result	Radiologic Finding
C35870	Conventional_Osteosarcoma	Central_Osteosarcoma	Conventional Osteosarcoma|Conventional Central Osteosarcoma
C35871	Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor_of_Bone	Ewing_s_Sarcoma_Peripheral_Primitive_Neuroectodermal_Tumor	Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor of Bone
C35873	Iatrogenic_Kaposi_s_Sarcoma	Kaposi_s_Sarcoma	Iatrogenic Kaposi's Sarcoma
C35874	Endemic_African_Kaposi_s_Sarcoma	Kaposi_s_Sarcoma	Endemic African Kaposi's Sarcoma
C35875	Bronchogenic_Carcinoma	Lung_Carcinoma	Bronchogenic Carcinoma|Bronchial Carcinoma|Bronchiogenic Carcinoma|Bronchogenic Lung Carcinoma	A lung carcinoma arising from the bronchial epithelium. (NCI05)
C35876	Childhood_Intracranial_Neoplasm	Intracranial_Neoplasm	Childhood Intracranial Neoplasm
C35877	Abnormal_Hematology_Test_Result	Abnormal_Blood_and_Hematology_Test_Result|Hematopoietic_System_Finding	Abnormal Hematology Test Result
C35878	Monoclonal_Paraproteinemia	Paraproteinemia	Monoclonal Paraproteinemia
C35879	Anisochromasia	Abnormal_Hematology_Test_Result	Anisochromasia
C35880	Blast_Cells_Present	Abnormal_Hematology_Test_Result	Blast Cells Present
C35881	Blast_Cells_Present_in_Peripheral_Blood	Blast_Cells_Present	Blast Cells Present in Peripheral Blood
C35882	Hereditary_Elliptocytosis	Genetic_Disorder|Non-Neoplastic_Hematologic_Disorder	Hereditary Elliptocytosis
C35883	Blast_Cells_Increased_in_Bone_Marrow	Abnormal_Bone_Marrow_Test_Result|Blast_Cells_Present	Blast Cells Increased in Bone Marrow
C35884	Monoclonal_Hypergammaglobulinemia	Hypergammaglobulinemia	Monoclonal Hypergammaglobulinemia
C35885	Polyclonal_Hypergammaglobulinemia	Hypergammaglobulinemia	Polyclonal Hypergammaglobulinemia
C35886	Morphologic_Architectural_Pattern	Morphologic_Finding	Morphologic Architectural Pattern
C35887	Herringbone_Growth_Pattern	Morphologic_Architectural_Pattern	Herringbone Growth Pattern
C35888	Storiform_Growth_Pattern	Morphologic_Architectural_Pattern	Storiform Growth Pattern
C35889	Whorling_Growth_Pattern	Morphologic_Architectural_Pattern	Whorling Growth Pattern
C35890	Plexiform_Growth_Pattern	Morphologic_Architectural_Pattern	Plexiform Growth Pattern
C35891	Lobulated_Growth_Pattern	Morphologic_Architectural_Pattern	Lobulated Growth Pattern|Lobular Pattern
C35892	Nested_Proliferation	Morphologic_Architectural_Pattern	Nested Proliferation
C35893	Pagetoid_Proliferation	Morphologic_Architectural_Pattern	Pagetoid Proliferation
C35894	Junctional_Proliferation	Morphologic_Architectural_Pattern	Junctional Proliferation
C35895	Compound_Growth_Pattern	Morphologic_Architectural_Pattern	Compound Growth Pattern
C35896	Dermal_Growth_Pattern	Morphologic_Architectural_Pattern	Dermal Growth Pattern
C35897	Radial_Growth_Phase	Morphologic_Architectural_Pattern	Radial Growth Phase
C35898	Vertical_Growth_Phase	Morphologic_Architectural_Pattern	Vertical Growth Phase
C35899	Nodular_Pattern	Morphologic_Architectural_Pattern	Nodular Pattern
C35900	Multinodular_Pattern	Nodular_Pattern	Multinodular Pattern
C35901	Pseudofollicular_Pattern	Morphologic_Architectural_Pattern	Pseudofollicular Pattern
C35902	Interfollicular_Pattern	Morphologic_Architectural_Pattern	Interfollicular Pattern
C35903	Diffuse_Pattern	Morphologic_Architectural_Pattern	Diffuse Pattern
C35904	Nodular_and_Diffuse_Pattern	Morphologic_Architectural_Pattern	Nodular and Diffuse Pattern
C35905	Angiocentric_Pattern	Morphologic_Architectural_Pattern	Angiocentric Pattern
C35906	Angiodestructive_Pattern	Morphologic_Architectural_Pattern	Angiodestructive Pattern
C35907	Biphasic_Pattern	Morphologic_Architectural_Pattern	Biphasic Pattern
C35908	Monophasic_Pattern	Morphologic_Architectural_Pattern	Monophasic Pattern
C35909	Antoni_A_Pattern	Morphologic_Architectural_Pattern	Antoni A Pattern
C35910	Antoni_B_Pattern	Morphologic_Architectural_Pattern	Antoni B Pattern
C35911	Papillary_Pattern	Morphologic_Architectural_Pattern	Papillary Pattern
C35912	Pseudopapillary_Pattern	Morphologic_Architectural_Pattern	Pseudopapillary Pattern
C35913	Trabecular_Pattern	Morphologic_Architectural_Pattern	Trabecular Pattern
C35914	Gyriform_Trabecular_Pattern	Trabecular_Pattern	Gyriform Trabecular Pattern
C35915	Macrotrabecular_Pattern	Trabecular_Pattern	Macrotrabecular Pattern
C35916	Insular_Pattern	Morphologic_Architectural_Pattern	Insular Pattern
C35917	Alveolar_Pattern	Morphologic_Architectural_Pattern	Alveolar Pattern
C35918	Organoid_Pattern	Morphologic_Architectural_Pattern	Organoid Pattern
C35919	Cylindromatous_Pattern	Morphologic_Architectural_Pattern	Cylindromatous Pattern
C35920	Cribriform_Pattern	Morphologic_Architectural_Pattern	Cribriform Pattern
C35921	Pseudoglandular_Pattern	Morphologic_Architectural_Pattern	Pseudoglandular Pattern
C35922	Acinar_Pattern	Morphologic_Architectural_Pattern	Acinar Pattern
C35923	Compact_Pattern	Morphologic_Architectural_Pattern	Compact Pattern
C35924	Scirrhous_Pattern	Morphologic_Architectural_Pattern	Scirrhous Pattern
C35925	Tubular_Pattern	Morphologic_Architectural_Pattern	Tubular Pattern
C35926	Glomeruloid_Pattern	Vascular_Morphologic_Change	Glomeruloid Vessels Present
C35927	Syncytial_Pattern	Morphologic_Architectural_Pattern	Syncytial Pattern
C35928	Triphasic_Pattern	Morphologic_Architectural_Pattern	Triphasic Pattern
C35929	Glandular_Pattern	Morphologic_Architectural_Pattern	Glandular Pattern
C35930	Endodermal_Sinus_Pattern	Morphologic_Architectural_Pattern	Endodermal Sinus Pattern
C35931	Reticular_Pattern	Morphologic_Architectural_Pattern	Honeycomb Pattern|Microcystic Pattern|Reticular Pattern
C35932	Sex_Cord-Like_Pattern	Morphologic_Architectural_Pattern	Sex Cord-Like Pattern
C35933	Distantly_Metastatic_Neoplasm	Metastatic_Malignant_Neoplasm	Distantly Metastatic Malignant Neoplasm
C35934	Locally_Metastatic_Neoplasm	Metastatic_Malignant_Neoplasm	Locally Metastatic Malignant Neoplasm	Cancer that has grown beyond the original (primary) tumor to nearby lymph nodes or organs and tissues.
C35935	Sessile_Lesion	Lesion	Sessile Lesion
C35936	Pedunculated_Lesion	Lesion	Pedunculated Lesion
C35937	Rhabdomyosarcomatous_Differentiation	Mesenchymal_Differentiation	Rhabdomyosarcomatous Differentiation
C35938	Epithelioid_Differentiation	Tissue_Differentiation	Epithelioid Differentiation
C35939	Tumor_Vascular_Invasion	Angioinvasion	Tumor Vascular Invasion
C35940	Rosette_Formation	Morphologic_Finding	Rosette Formation
C35941	Flexner-Wintersteiner_Rosette_Formation	Rosette_Formation	Flexner-Wintersteiner Rosette Formation
C35942	Homer-Right_Rosette_Formation	Rosette_Formation	Homer Wright Rosette Formation
C35943	Pseudorosette_Formation	Rosette_Formation	Pseudorosette Formation
C35944	Ependymal_Rosette_Formation	Rosette_Formation	Ependymal Rosette Formation
C35945	Pineocytomatous_Rosette_Formation	Rosette_Formation	Pineocytomatous Rosette Formation
C35946	Multilayered_Rosette_Formation	Rosette_Formation	Multilayered Rosette Formation
C35947	Cementum_Formation	Morphologic_Finding	Cementum Formation
C35948	Dentin_Formation	Morphologic_Finding	Dentin Formation
C35949	Enamel_Formation	Morphologic_Finding	Enamel Formation
C35950	Fleurette_Formation	Morphologic_Finding	Fleurette Formation
C35951	Squamous_Pearl_Formation	Morphologic_Finding	Squamous Pearl Formation
C35952	Arias-Stella_Reaction	Morphologic_Finding	Arias-Stella Reaction
C35953	Hydropic_Villous_Change	Morphologic_Finding	Hydropic Villous Change
C35954	Stromal_Invasion	Morphologic_Finding	Stromal Invasion
C35955	Absence_of_Stromal_Invasion	Absence_of_Invasion	Absence of Stromal Invasion
C35956	Fibrinoid_Necrosis	Necrotic_Change	Fibrinoid Necrosis
C35957	Tumor_Cell_Necrosis	Morphologic_Finding	Tumor Cell Necrosis
C35958	Comedo-Like_Necrosis	Tumor_Cell_Necrosis	Comedo-Like Necrosis
C35959	Mitotic_Activity	Morphologic_Finding	Mitotic Activity|mitotic activity	Having to do with the presence of dividing (proliferating) cells. Cancerous tissue generally has more mitotic activity than normal tissues.
C35960	High_Mitotic_Activity	Mitotic_Activity	High Mitotic Activity
C35961	Low_Mitotic_Activity	Mitotic_Activity	Low Mitotic Activity
C35962	Atypical_Mitotic_Figures	Morphologic_Finding	Atypical Mitotic Figures
C35963	Vascular_Morphologic_Change	Morphologic_Finding	Vascular Morphologic Change
C35964	Cavernous-Like_Vascular_Space_Formation	Vascular_Morphologic_Change	Cavernous-Like Vascular Space Formation
C35965	Cavernous_Lymphatic_Space_Formation	Vascular_Morphologic_Change	Cavernous Lymphatic Space Formation
C35966	Dilated_Thick-Walled_Vascular_Space_Formation	Vascular_Morphologic_Change	Dilated Thick-Walled Vascular Space Formation
C35967	Dilated_Thin-Walled_Vascular_Space_Formation	Vascular_Morphologic_Change	Dilated Thin-Walled Vascular Space Formation
C35968	Intravascular_Thrombus_Formation	Vascular_Morphologic_Change	Intravascular Thrombus Formation
C35969	Thin-Walled_Branching_Vascular_Pattern	Vascular_Morphologic_Change	Thin-Walled Branching Vascular Pattern
C35970	Staghorn_Configuration	Thin-Walled_Branching_Vascular_Pattern	Staghorn Configuration
C35971	Angiectoid_Space_Formation	Vascular_Morphologic_Change	Angiectoid Space Formation
C35972	Small_Capillary-Sized_Vascular_Proliferation	Microvascular_Proliferation	Small Capillary-Sized Vascular Proliferation
C35973	Irregular_Vascular_Channel_Formation	Vascular_Channel_Formation	Irregular Vascular Channel Formation
C35974	Sinusoidal_Vascular_Channel_Formation	Vascular_Channel_Formation	Sinusoidal Vascular Channel Formation
C35975	Arborizing_Vascular_Channel_Formation	Vascular_Channel_Formation	Arborizing Vascular Channel Formation
C35976	Vascular_Channel_Formation	Vascular_Morphologic_Change	Vascular Channel Formation
C35977	Lobular_Capillary_Arrangement	Vascular_Morphologic_Change	Lobular Capillary Arrangement
C35978	Inflammatory_Infiltrate	Cellular_Infiltrate	Inflammatory Infiltrate
C35979	Acute_Inflammatory_Infiltrate	Inflammatory_Infiltrate	Acute Inflammatory Infiltrate
C35980	Chronic_Inflammatory_Infiltrate	Inflammatory_Infiltrate	Chronic Inflammatory Infiltrate
C35981	Eosinophilic_Infiltrate	Acute_Inflammatory_Infiltrate	Eosinophilic Infiltrate
C35982	Neutrophilic_Infiltrate	Acute_Inflammatory_Infiltrate	Neutrophilic Infiltrate
C35983	Lymphocytic_Infiltrate	Cellular_Infiltrate	Lymphocytic Infiltrate
C35984	Lymphoplasmacytic_Infiltrate	Cellular_Infiltrate	Lymphoplasmacytic Infiltrate
C35985	Hemophagocytosis	Morphologic_Finding	Hemophagocytosis	The term hemophagocytosis describes the pathologic finding of activated macrophages, engulfing erythrocytes, leukocytes, platelets, and their precursor cells. (from Medscape: Hemophagocytic Syndromes and Infection)
C35986	Onion-Skinning_Appearance	Morphologic_Finding	Onion-Skinning Appearance
C35987	Emperipolesis	Morphologic_Finding	Emperipolesis
C35988	Metaplastic_Bone_Formation	Morphologic_Finding	Metaplastic Bone Formation
C35989	Nuclear_Atypia_Present	Atypia	Nuclear Atypia|Nuclear Atypia Present
C35990	Hemosiderin_Deposition	Deposit	Hemosiderin Deposition
C35991	Red_Blood_Cells_Extravasation	Morphologic_Finding	Red Blood Cells Extravasation
C35992	Dystrophic_Calcification	Calcification	Dystrophic Calcification
C35993	Neoplastic_Bone_Formation	Morphologic_Finding	Neoplastic Bone Formation
C35994	Pseudoangiomatoid_Space_Formation	Morphologic_Finding	Pseudoangiomatoid Space Formation
C35995	Ringed_Sideroblasts_Present	Abnormal_Bone_Marrow_Test_Result	Ringed Sideroblasts Present
C35996	Stromal_Change	Abnormal_Tissue_Present	Stromal Change
C35997	Vascular_Collagenous_Stroma_Formation	Stromal_Change	Vascular Collagenous Stroma Formation
C35998	Myxoid_Stroma_Formation	Stromal_Change	Myxoid Stroma Formation
C35999	Mucinous_Stroma_Formation	Stromal_Change	Mucoid Stroma Formation
C36000	Hyalinized_Stroma_Formation	Stromal_Change	Hyalinized Stroma Formation
C36001	Fibromyxoid_Stroma_Formation	Stromal_Change	Fibromyxoid Stroma Formation
C36002	Chondromyxoid_Stroma_Formation	Stromal_Change	Chondromyxoid Stroma Formation
C36003	Desmoplastic_Stroma_Formation	Stromal_Change	Desmoplastic Stroma Formation
C36004	Fibroblastic_Stroma_Formation	Fibrotic_Stroma_Formation	Fibroblastic Stroma Formation
C36005	Edematous_Stroma_Formation	Stromal_Change	Edematous Stroma Formation
C36006	Stromal_Hemorrhage_Present	Stromal_Change	Stromal Hemorrhage Present
C36007	Cast_Formation	Morphologic_Finding	Cast Formation
C36008	Erythrocytic_Cast_Formation	Cast_Formation	Erythrocytic Cast Formation
C36009	Leukocytic_Cast_Formation	Cast_Formation	Leukocytic Cast Formation
C36010	Central_Scar	Scar	Central Scar
C36011	Decidual_Reaction	Morphologic_Finding	Decidual Reaction
C36012	Nodular_Neoplasm	Neoplasm_by_Special_Category	Nodular Neoplasm|Nodular Tumor
C36013	Bid-Like_Elastic_Fiber	Morphologic_Finding	Bid-Like Elastic Fibers Present
C36014	Russell_Body	Morphologic_Finding	Russell Body
C36015	Asbestos_Body	Morphologic_Finding	Asbestos Body
C36016	Michaelis-Gutmann_Body	Morphologic_Finding	Michaelis-Gutmann Body
C36017	Nuclear_Inclusion	Morphologic_Finding	Nuclear Inclusion
C36018	Ground_Glass_Nuclear_Inclusion	Nuclear_Inclusion	Ground Glass Nuclear Inclusion
C36019	Cowdry_Type_A_Eosinophilic_Intranuclear_Inclusion	Nuclear_Inclusion	Cowdry Type A Eosinophilic Intranuclear Inclusion
C36020	Dutcher_Body	Nuclear_Inclusion	Dutcher Body
C36021	Corpora_Amylacea	Morphologic_Finding	Corpora Amylacea|Blue Body
C36022	Verocay_Body	Morphologic_Finding	Verocay Bodies Present
C36023	Call_Exner_Body	Morphologic_Finding	Call Exner Bodies Present
C36024	Stary_Sky_Pattern	Morphologic_Finding	Starry Sky Pattern
C36025	Anaplastic_Malignant_Neoplasm	Malignant_Neoplasm	Anaplastic Malignant Neoplasm
C36026	Diffuse_Cellular_Infiltrate	Cellular_Infiltrate	Diffuse Cellular Infiltrate
C36027	Non-Invasive_Lesion	Lesion_by_Morphology	Non-Invasive Lesion
C36028	Microinvasive_Malignant_Neoplasm	Invasive_Malignant_Neoplasm	Microinvasive Malignant Neoplasm
C36029	Necrotic_Neoplasm	Neoplasm_by_Special_Category	Necrotic Neoplasm
C36030	Osteolytic_Neoplasm	Neoplasm_by_Special_Category	Osteolytic Neoplasm
C36031	Papillary_Neoplasm	Neoplasm_by_Special_Category	Papillary Neoplasm|Papillary Tumor|papillary tumor	(PAP-ih-lar-ee TOO-mer) A tumor shaped like a small mushroom, with its stem attached to the epithelial layer (inner lining) of an organ.
C36032	Premalignant_Neoplasm	Neoplasm_by_Special_Category	Premalignant Neoplasm
C36033	Tubular_Neoplasm	Neoplasm_by_Special_Category	Tubular Neoplasm
C36034	Villous_Neoplasm	Neoplasm_by_Special_Category	Villous Neoplasm
C36035	Encapsulated_Neoplasm	Neoplasm_by_Special_Category	Encapsulated Neoplasm
C36036	Non-Encapsulated_Neoplasm	Neoplasm_by_Special_Category	Non-Encapsulated Neoplasm
C36037	Non-Metastatic_Neoplasm	Neoplasm_by_Special_Category	Non-Metastatic Neoplasm
C36038	Non-Lytic_Metastatic_Lesion	Metastatic_Lesion|Radiologic_Finding	Non-Lytic Metastatic Lesion|Nonlytic Metastatic Lesion
C36039	Grade_1_Malignant_Neoplasm	Malignant_Neoplasm_by_Grade	Grade 1 Malignant Neoplasm
C36040	Grade_2_Malignant_Neoplasm	Malignant_Neoplasm_by_Grade	Grade 2 Malignant Neoplasm
C36041	Malignant_Neoplasm_by_Grade	Malignant_Neoplasm	Malignant Neoplasm by Grade
C36042	Grade_3_Malignant_Neoplasm	Malignant_Neoplasm_by_Grade	Grade 3 Malignant Neoplasm
C36043	Grade_3a_Malignant_Neoplasm	Grade_3_Malignant_Neoplasm	Grade 3a Malignant Neoplasm
C36044	Grade_3b_Malignant_Neoplasm	Grade_3_Malignant_Neoplasm	Grade 3b Malignant Neoplasm
C36045	Grade_4_Malignant_Neoplasm	Malignant_Neoplasm_by_Grade	Grade 4 Malignant Neoplasm
C36046	High_Grade_Malignant_Neoplasm	Malignant_Neoplasm_by_Grade	High Grade Malignant Neoplasm
C36047	Intermediate_Grade_Malignant_Neoplasm	Malignant_Neoplasm_by_Grade	Intermediate Grade Malignant Neoplasm
C36048	Low_Grade_Malignant_Neoplasm	Malignant_Neoplasm_by_Grade	Low Grade Malignant Neoplasm
C36049	Moderately_Differentiated_Malignant_Neoplasm	Malignant_Neoplasm	Moderately Differentiated Malignant Neoplasm
C36050	Poorly_Differentiated_Malignant_Neoplasm	Malignant_Neoplasm	Poorly Differentiated Malignant Neoplasm
C36051	Undifferentiated_Malignant_Neoplasm	Malignant_Neoplasm	Undifferentiated Malignant Neoplasm
C36052	Well_Differentiated_Malignant_Neoplasm	Malignant_Neoplasm	Well Differentiated Malignant Neoplasm
C36053	Epithelial_Predominant_Pulmonary_Blastoma	Pulmonary_Blastoma	Epithelial Predominant Pulmonary Blastoma	A non-encapsulated, well defined pulmonary blastoma, composed of irregular tubular structures.  It affects mostly middle-aged adults and it is rare in children.  The prognosis is better compared to the biphasic pulmonary blastoma. --2003
C36054	Biphasic_Pulmonary_Blastoma	Pulmonary_Blastoma	Biphasic Pulmonary Blastoma|Classic Pulmonary Blastoma	A pulmonary blastoma composed of a mixture of irregular tubular structures and mesenchymal elements. --2003
C36055	Acute_Promyelocytic_Leukemia_with_Variant_Translocations	Acute_Promyelocytic_Leukemia	Acute Promyelocytic Leukemia with Variant Translocations
C36056	Acute_Promyelocytic_Leukemia_with_t_11_17_q23_q21	Acute_Promyelocytic_Leukemia_with_Variant_Translocations	Acute Promyelocytic Leukemia with t(11;17)(q23;q21)
C36057	Acute_Promyelocytic_Leukemia_with_t_5_17_q32_q12	Acute_Promyelocytic_Leukemia_with_Variant_Translocations	Acute Promyelocytic Leukemia with t(5;17)(q32;q12)
C36058	Acute_Promyelocytic_Leukemia_with_t_11_17_q13_q21	Acute_Promyelocytic_Leukemia_with_Variant_Translocations	Acute Promyelocytic Leukemia with t(11;17)(q13;q21)
C36059	Granuloma-Like_Growth_Pattern	Morphologic_Architectural_Pattern	Granuloma-Like Growth Pattern
C36060	Chronic_Myelomonocytic_Leukemia_with_Eosinophilia	Chronic_Myelomonocytic_Leukemia	Chronic Myelomonocytic Leukemia with Eosinophilia|CMML with Eosinophilia
C36061	Chronic_Myelomonocytic_Leukemia-1	Chronic_Myelomonocytic_Leukemia	Chronic Myelomonocytic Leukemia-1|CMML-1
C36062	Chronic_Myelomonocytic_Leukemia-2	Chronic_Myelomonocytic_Leukemia	Chronic Myelomonocytic Leukemia-2|CMML-2
C36063	Hemorrhagic_Ascites	Ascites	Hemorrhagic Ascites
C36064	Vaginal_Stricture	Reproductive_System_Finding	Vaginal Stricture
C36065	Superior_Vena_Cava_Occlusion	Vena_Cava_Occlusion	Superior Vena Cava Occlusion
C36066	Orbivirus_Infection	Viral_Infection	Orbivirus Infection
C36067	Clostridium_Colitis	Colitis	Clostridium Colitis
C36068	Posteroinferior_Myocardial_Infarction	Myocardial_Infarction	Posteroinferior Myocardial Infarction
C36069	Dental_and_Periodontal_Infection	Infectious_Disorder_by_Site	Dental and Periodontal Infection
C36070	Abdominal_and_Gastrointestinal_Infection	Infectious_Disorder_by_Site	Abdominal and Gastrointestinal Infection
C36071	Chronic_Polyneuropathy	Polyneuropathy	Chronic Polyneuropathy
C36072	Abnormal_Phenolsulfonphthalein_Test	Abnormal_Blood_and_Hematology_Test_Result	Abnormal Phenolsulfonphthalein Test Result|Abnormal PSP Test
C36073	Apical_Myocardial_Infarction	Myocardial_Infarction	Apical Myocardial Infarction
C36074	Metastatic_Peripheral_Primitive_Neuroectodermal_Tumor_of_Bone	Peripheral_Neuroectodermal_Tumor_of_Bone	Metastatic Peripheral Primitive Neuroectodermal Tumor of Bone|Metastatic Peripheral Neuroepithelioma of Bone
C36075	Rosai-Dorfman_Disease	Non-Neoplastic_Hematologic_Disorder	Sinus Histiocytosis with Massive Lymphadenopathy|Rosai-Dorfman Disease
C36076	Malignant_Reproductive_System_Neoplasm	Reproductive_System_Neoplasm	Malignant Reproductive System Neoplasm
C36077	Hilar_Cholangiocarcinoma	Cholangiocarcinoma|Extrahepatic_Bile_Duct_Adenocarcinoma	Hilar Cholangiocarcinoma|Hilar Cholangiocellular Carcinoma	A cholangiocarcinoma arising from the hilar ducts located at the hilar area of the liver. --2003
C36078	Sideroblastic_Anemia	Anemia	Sideroblastic Anemia	A myelodysplastic syndrome characterized mainly by dysplasia of the erythroid series.  Refractory anemia is uncommon.  It is primarily a disease of older adults.  The median survival exceeds 5 years.  (WHO, 2001) -- 2003
C36079	Subungual_Glomus_Tumor	Glomus_Tumor	Subungual Glomus Tumor
C36080	Diffuse_Large_B-Cell_Lymphoma_with_a_Germinal_Center_B-Cell_Expression_Profile	Diffuse_Large_B-Cell_Lymphoma_by_Gene_Expression_Profile	Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma|Diffuse Large B-Cell Lymphoma with a Germinal Center B-Cell Expression Profile|GCB-DLBCL	A recently recognized biologic subset of diffuse large B-cell lymphomas with a unique molecular signature or expression profile.  It represents approximately 50% of diffuse large B-cell lymphomas, and is characterized by the expression of CD10, BCL-6, A-myb, and LMO2 genes, BCL-2 translocation, and c-REL amplification.  Morphologically, the vast majority of these lymphomas are centroblastic and a small minority are immunoblastic (ratio20:1).  Patients with this type of diffuse large B-cell lymphoma have a more favorable outcome, with a 5-year survival rate of 60% and a median survival of 10 years. -- 2004
C36081	Diffuse_Large_B-Cell_Lymphoma_with_an_Activated_B-Cell_Expression_Profile	Aggressive_Non-Hodgkin_s_Lymphoma|Diffuse_Large_B-Cell_Lymphoma_by_Gene_Expression_Profile	Activated B-Cell-Like Diffuse Large B-Cell Lymphoma|ABC-DLBCL|Diffuse Large B-Cell Lymphoma with an Activated B-Cell Expression Profile	A recently recognized biologic subset of diffuse large B-cell lymphomas with a unique molecular signature or expression profile.  It represents approximately 30% of diffuse large B-cell lymphomas, and is characterized by the expression of CD44, PKCbeta1, Cyclin D2, BCL-2, and IRF4/MUM1 genes.  Morphologically, these lymphomas are either centroblastic or immunoblastic (ratio 2:1).  Patients with this type of diffuse large B-cell lymphoma are reported to have a less favorable outcome compared to those with a germinal center B-cell expression profile, with a 5-year survival rate of 35% and a median survival of 2 years. -- 2004
C36082	Metastatic_Carcinoma_to_the_Bone	Metastatic_Carcinoma|Metastatic_Neoplasm_to_the_Bone	Metastatic Carcinoma to the Bone|Bone Carcinoma	A carcinoma that has spread to the bone from another, primary anatomic site.  Bone is one of the most frequent sites of metastatic carcinoma.  Common sites of origin include lung, breast, and prostate. --2003
C36083	Intraductal_Breast_Neoplasm	Breast_Neoplasm	Intraductal Breast Neoplasm
C36084	Invasive_Micropapillary_Breast_Carcinoma	Invasive_Papillary_Breast_Carcinoma	Invasive Micropapillary Breast Carcinoma|Infiltrating Micropapillary Breast Carcinoma
C36085	Invasive_Papillary_Breast_Carcinoma	Invasive_Breast_Carcinoma|Papillary_Breast_Carcinoma	Invasive Papillary Breast Carcinoma|Infiltrating Papillary Breast Carcinoma
C36086	Flat_Ductal_Epithelial_Atypia_of_the_Breast	Mammary_Intraepithelial_Neoplasia_Ductal_Type	Flat Ductal Epithelial Atypia of the Breast|DIN 1A|Ductal Intraepithelial Neoplasia, Grade 1A|Flat Ductal Epithelial Atypia
C36087	Central_Papilloma	Intraductal_Breast_Papilloma	Central Breast Papilloma|Large Duct Breast Papilloma
C36088	Peripheral_Papilloma	Intraductal_Breast_Papilloma	Peripheral Breast Papilloma|Microscopic Breast Papilloma
C36089	Atypical_Breast_Papilloma	Intraductal_Breast_Papilloma	Atypical Breast Papilloma
C36090	Intraductal_Papillary_Breast_Neoplasm	Intraductal_Breast_Neoplasm|Papillary_Breast_Neoplasm	Intraductal Papillary Breast Neoplasm
C36091	Crystal_of_Reinke_Formation	Crystal_Formation	Reinke Crystals Formation
C36092	Testicular_Dermoid_Cyst	Dermoid_Cyst|Testicular_Teratoma	Testicular Dermoid Cyst
C36093	Endometrial_Mucinous_Adenocarcinoma	Retired_Concepts	Endometrial Mucinous Adenocarcinoma
C36094	Early_Invasive_Cervical_Squamous_Cell_Carcinoma	Cervical_Squamous_Cell_Carcinoma	Early Invasive Cervical Squamous Cell Carcinoma|Microinvasive Cervical Squamous Cell Carcinoma
C36095	Cervical_Mucinous_Adenocarcinoma	Cervical_Adenocarcinoma|Mucinous_Adenocarcinoma	Cervical Mucinous Adenocarcinoma
C36096	Early_Invasive_Cervical_Adenocarcinoma	Cervical_Adenocarcinoma	Early Invasive Cervical Adenocarcinoma
C36097	Cervical_Malignant_Mixed_Mesodermal_Mullerian_Tumor	Malignant_Cervical_Mixed_Epithelial_and_Mesenchymal_Neoplasm|Uterine_Carcinosarcoma	Cervical Carcinosarcoma|Cervical Malignant Mixed Mesodermal (Mullerian) Tumor
C36098	Childhood_Botryoid-Type_Embryonal_Rhabdomyosarcoma_of_the_Vulva	Childhood_Botryoid-Type_Embryonal_Rhabdomyosarcoma|Vulvar_Sarcoma	Childhood Botryoid-Type Embryonal Rhabdomyosarcoma of the Vulva|Childhood Sarcoma Botryoides of the Vulva|Vulvar Childhood Botryoid-Type Embryonal Rhabdomyosarcoma
C36099	Adult_Botryoid-Type_Embryonal_Rhabdomyosarcoma	Adult_Rhabdomyosarcoma|Botryoid-Type_Embryonal_Rhabdomyosarcoma	Adult Botryoid-Type Embryonal Rhabdomyosarcoma|Adult Botryoid Sarcoma
C36100	BRCA_1_Syndrome	Hereditary_Breast_and_Ovarian_Cancer_Syndrome	BRCA 1 Syndrome|Early Onset Breast Ovarian Cancer Syndrome
C36101	BRCA_2_Syndrome	Hereditary_Breast_and_Ovarian_Cancer_Syndrome	BRCA 2 Syndrome|Site Specific Early Onset Breast Cancer Syndrome
C36102	Hereditary_Ovarian_Carcinoma	Familial_Cancer|Ovarian_Carcinoma	Hereditary Ovarian Carcinoma|Familiar Ovarian Carcinoma
C36103	Rapidly_Enlarging_Mass	Mass	Rapidly Enlarging Mass
C36104	Aggressive_Clinical_Course	Clinical_Course_of_Disease	Aggressive Clinical Course
C36105	Indolent_Clinical_Course	Clinical_Course_of_Disease	Indolent Clinical Course
C36106	Hereditary_Male_Breast_Carcinoma	Hereditary_Breast_Carcinoma|Male_Breast_Carcinoma	Hereditary Male Breast Carcinoma|Familiar Male Breast Carcinoma
C36107	Hereditary_Female_Breast_Carcinoma	Female_Breast_Carcinoma|Hereditary_Breast_Carcinoma	Hereditary Female Breast Carcinoma|Familiar Female Breast Carcinoma
C36108	Encapsulated_Mass	Mass	Encapsulated Mass
C36109	Superficial_Lesion	Lesion	Superficial Lesion
C36110	Non-Measurable_Lesion	Lesion	Non-Measurable Lesion
C36111	Non-Metastatic_Mass	Mass	Non-Metastatic Mass|Nonmetastatic Mass
C36112	Metastatic_Mass	Mass	Metastatic Mass
C36113	Anaplastic_Lesion	Lesion_by_Morphology	Anaplastic Lesion|Anaplasia|Anaplastic Change
C36114	Non-Melanomatous_Lesion	Lesion_by_Morphology	Non-Melanomatous Lesion
C36115	Malignant_Cellular_Infiltrate	Cellular_Infiltrate	Malignant Cellular Infiltrate
C36116	Borderline_Lesion	Premalignant_Lesion	Borderline Lesion
C36117	Invasive_Lesion	Lesion_by_Morphology	Invasive Lesion
C36118	In_Situ_Lesion	Non-Invasive_Lesion	In Situ Lesion
C36119	Mucinous_Lesion	Lesion_by_Morphology	Mucinous Lesion
C36120	Serous_Lesion	Lesion_by_Morphology	Serous Lesion
C36121	Villous_Pattern	Morphologic_Architectural_Pattern	Villous Pattern
C36122	Benign_Cellular_Infiltrate	Cellular_Infiltrate	Benign Cellular Infiltrate
C36123	Necrotic_Lesion	Lesion_by_Morphology	Necrotic Lesion
C36124	Microinvasive_Lesion	Invasive_Lesion	Microinvasive Lesion
C36125	Non-Malignant_Cellular_Infiltrate	Cellular_Infiltrate	Non-Malignant Cellular Infiltrate
C36126	Premalignant_Change	Morphologic_Finding	Premalignant Change
C36127	Non-Seminomatous_Lesion	Lesion_by_Morphology	Non-Seminomatous Lesion|Nonseminomatous Lesion
C36128	Comedo_Change	Morphologic_Finding	Comedo Change|Comedo Lesion
C36129	High_Grade_Lesion	Lesion_by_Grade	High Grade Lesion
C36130	Low_Grade_Lesion	Lesion_by_Grade	Low Grade Lesion
C36131	Moderately_Differentiated_Lesion	Lesion_by_Morphology	Moderately Differentiated Lesion
C36132	Poorly_Differentiated_Lesion	Lesion_by_Morphology	Poorly Differentiated Lesion
C36133	Well_Differentiated_Lesion	Lesion_by_Morphology	Well Differentiated Lesion
C36134	Undifferentiated_Lesion	Lesion_by_Morphology	Undifferentiated Lesion
C36135	Grade_1_Lesion	Lesion_by_Grade	Grade 1 Lesion
C36136	Grade_2_Lesion	Lesion_by_Grade	Grade 2 Lesion
C36137	Grade_3_Lesion	Lesion_by_Grade	Grade 3 Lesion
C36138	Grade_3a_Lesion	Grade_3_Lesion	Grade 3a Lesion
C36139	Grade_3b_Lesion	Grade_3_Lesion	Grade 3b Lesion
C36140	Grade_4_Lesion	Lesion_by_Grade	Grade 4 Lesion
C36141	Intermediate_Grade_Lesion	Lesion_by_Grade	Intermediate Grade Lesion
C36142	Stage_I_Lesion	Lesion_by_Stage	Stage I Lesion
C36143	Stage_II_Lesion	Lesion_by_Stage	Stage II Lesion
C36144	Stage_III_Lesion	Lesion_by_Stage	Stage III Lesion
C36145	Stage_IV_Lesion	Lesion_by_Stage	Stage IV Lesion
C36146	Stage_A_Lesion	Lesion_by_Stage	Stage A Lesion
C36147	Stage_B_Lesion	Lesion_by_Stage	Stage B Lesion
C36148	Stage_C_Lesion	Lesion_by_Stage	Stage C Lesion
C36149	Stage_D_Lesion	Lesion_by_Stage	Stage D Lesion
C36150	Extensive_Stage_Lesion	Lesion_by_Stage	Extensive Stage Lesion
C36151	Limited_Stage_Lesion	Lesion_by_Stage	Limited Stage Lesion
C36152	Unspecified_Stage_Lesion	Lesion_by_Stage	Unspecified Stage Lesion
C36153	Stage_Is_Lesion	Lesion_by_Stage	Stage Is Lesion
C36154	Chronic_Phase_of_Disease	Clinical_Course_of_Disease	Chronic Phase of Disease
C36155	Accelerated_Phase_of_Disease	Clinical_Course_of_Disease	Accelerated Phase of Disease
C36156	Favorable_Clinical_Outcome	Clinical_Course_of_Disease	Favorable Clinical Outcome
C36157	Acute_Clinical_Course	Clinical_Course_of_Disease	Acute Clinical Course
C36158	Chronic_Clinical_Course	Clinical_Course_of_Disease	Chronic Clinical Course
C36159	Progressive_Clinical_Course	Clinical_Course_of_Disease	Progressive Clinical Course
C36160	Newly_Diagnosed_Disease	Clinical_Course_of_Disease	Newly Diagnosed Disease
C36162	Localized_Disease	Clinical_Course_of_Disease	Localized Disease
C36163	Metastatic_Recurrent_Disease	Clinical_Course_of_Disease	Metastatic/Recurrent Disease
C36164	Metasynchronous_Lesion	Lesion	Metasynchronous Lesion
C36165	Unresectable_Mass	Mass	Unresectable Mass
C36166	Resectable_Mass	Mass	Resectable Mass
C36167	Resected_Mass	Mass	Resected Mass
C36168	Hormone_Responsive_Mass	Mass	Hormone Responsive Mass
C36169	Hemorrhagic_Fever	Fever	Hemorrhagic Fever
C36170	Viral_Hemorrhagic_Fever	Viral_Infection	Viral Hemorrhagic Fever
C36171	Ebola_Hemorrhagic_Fever	Viral_Hemorrhagic_Fever	Ebola Hemorrhagic Fever
C36172	Sweating	Body_Temperature_Associated_Symptom	Sweating|Sweats	Sweating is the loss of a watery fluid, consisting mainly of sodium chloride and urea in solution, that is secreted by the sweat glands in the skin of mammals. (from Wikipedia)
C36173	Prolapse	Congenital_or_Acquired_Anatomic_Abnormality	Prolapse|Procidentia
C36174	Negative_Lymph_Node	Negative_Test_Result	Negative Lymph Node
C36175	Stellate_Configuration	Morphologic_Finding	Stellate Configuration
C36176	Bilateral_Mass	Mass	Bilateral Mass
C36177	Single-File_Linear_Pattern	Morphologic_Architectural_Pattern	Single-File Linear Pattern
C36178	Fibrotic_Stroma_Formation	Stromal_Change	Fibrotic Stroma Formation
C36179	Paget_Involvement	Morphologic_Finding	Paget Involvement
C36180	Multifocal_Lesion	Lesion_by_Focality	Multifocal Lesion
C36181	Micropapillary_Pattern	Papillary_Pattern	Micropapillary Pattern
C36182	Solid_Pattern	Morphologic_Architectural_Pattern	Solid Growth Pattern|Solid Pattern
C36183	Firm_Mass	Mass	Firm Mass
C36184	Necrotic_Change	Morphologic_Finding	Necrotic Change
C36185	Fatty_Change	Morphologic_Finding	Fatty Change
C36186	Globular_Hyaline_Body	Morphologic_Finding	Globular Hyaline Body
C36187	Thorotrast_Exposure	Chemical_Exposure	Thorotrast Exposure
C36188	Multinodular_Mass	Mass	Multinodular Mass
C36189	Fetal_Epithelial_Differentiation	Epithelial_Differentiation	Fetal -Epithelial Differentiation
C36190	Mesenchymal_Differentiation	Tissue_Differentiation	Mesenchymal Differentiation
C36191	Neurosecretory_Granule	Morphologic_Finding	Neurosecretory Granules Present
C36192	Arteriovenous_Fistula	Fistula	Arteriovenous Fistula
C36193	Bilateral_Deafness	Deafness	Bilateral Deafness
C36194	Complete_Deafness	Deafness	Complete Deafness|Complete Hearing Loss|Total Deafness
C36195	Skin_Granuloma	Granuloma_by_Site	Skin Granuloma|Granuloma of Skin|Granuloma of the Skin
C36196	Vena_Cava_Occlusion	Vascular_Disorder	Vena Cava Occlusion
C36197	Mycobacterium_Avium_Infection	Mycobacterial_Infection	Mycobacterium Avium Infection
C36198	Astler-Coller_C2_Colon_Carcinoma	Astler-Coller_C2_Colorectal_Carcinoma|Colon_Cancer_by_Astler-Coller_Stage	Astler-Coller C2 Colon Carcinoma	Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.) - 2003
C36199	Astler-Coller_C1_Colon_Carcinoma	Astler-Coller_C1_Colorectal_Carcinoma|Colon_Cancer_by_Astler-Coller_Stage	Astler-Coller C1 Colon Carcinoma	Stage III includes: IIIA (T1-T2, N1, M0); IIIB (T3-T4, N1, M0); IIIC (Any T, N2, M0). N1: Metastasis in 1 to 3 regional lymph nodes.  N2: Metastasis in 4 or more regional lymph nodes. M0: No distant metastasis. (AJCC 6th ed.) - 2003
C36200	Astler-Coller_B2_Rectal_Carcinoma	Astler-Coller_B2_Colorectal_Carcinoma|Rectal_Cancer_by_Astler-Coller_Stage	Astler-Coller B2 Rectal Carcinoma
C36201	Astler-Coller_B2_Colorectal_Carcinoma	Colorectal_Cancer_by_Astler-Coller_Stage	Astler-Coller B2 Colorectal Carcinoma
C36202	Astler-Coller_A_Colon_Carcinoma	Astler-Coller_A_Colorectal_Carcinoma|Colon_Cancer_by_Astler-Coller_Stage	Astler-Coller A Colon Carcinoma	Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria.  N0: No regional lymph node metastasis.  M0: No distant metastasis. (AJCC 6th ed.)-2003
C36203	Astler-Coller_B1_Rectal_Carcinoma	Astler-Coller_B1_Colorectal_Carcinoma|Rectal_Cancer_by_Astler-Coller_Stage	Astler-Coller B1 Rectal Carcinoma	Stage I includes: (T1, N0, M0) and (T2, N0, M0).  T1: Tumor invades submucosa.  T2: Tumor invades muscularis propria. (AJCC 6th ed.) -2003
C36204	Astler-Coller_B1_Colorectal_Carcinoma	Colorectal_Cancer_by_Astler-Coller_Stage	Astler-Coller B1 Colorectal Carcinoma
C36205	Peutz-Jeghers_Polyp_of_the_Stomach	Gastric_Polyp|Peutz-Jeghers_Polyp	Peutz-Jeghers Polyp of the Stomach|Gastric Peutz-Jeghers Polyp
C36206	Small_Intestinal_Polyp	Gastrointestinal_Polyp	Small Intestinal Polyp|Polyp of the Small Bowel|Polyp of the Small Intestine|Small Bowel Polyp
C36207	Gastrointestinal_Adenoma	Gastrointestinal_Neoplasm|Gastrointestinal_Polyp	Gastrointestinal Adenoma|GI Adenoma
C36208	Myeloblasts_Under_2_Percent_of_Peripheral_Blood_White_Cells	Myeloblasts_Under_5_Percent_of_Peripheral_Blood_White_Cells	Myeloblasts Under 2 Percent of Peripheral Blood White Cells|Myeloblasts Under 2% of Peripheral Blood White Cells
C36209	Myeloblasts_Under_5_Percent_of_Bone_Marrow_Nucleated_Cells	Myeloblasts_Under_10_Percent_of_Bone_Marrow_Nucleated_Cells	Myeloblasts Under 5 Percent of Bone Marrow Nucleated Cells|Myeloblasts Under 5% of Bone Marrow Nucleated Cells
C36210	Myeloblasts_10-19_Percent_of_Bone_Marrow_Nucleated_Cells	Blasts_10-19_Percent_of_Bone_Marrow_Nucleated_Cells|Immature_Myeloid_Cells_Increased_in_Bone_Marrow|Myeloblasts_5-19_Percent_of_Bone_Marrow_Nucleated_Cells	Myeloblasts 10-19 Percent of Bone Marrow Nucleated Cells|Myeloblasts Between 10 and 19 Percent of Bone Marrow Nucleated Cells|Myeloblasts Between 10 and 19% of Bone Marrow Nucleated Cells
C36211	Myeloblasts_10-19_Percent_of_Peripheral_Blood_White_Cells	Myeloblasts_5-19_Percent_of_Peripheral_Blood_White_Cells	Myeloblasts 10-19 Percent of Peripheral Blood White Cells|Myeloblasts Between 10 and 19% of Peripheral Blood White Cells
C36212	Bone_Marrow_Fibrosis	Fibrosis	Bone Marrow Fibrosis
C36213	Blasts_20_Percent_or_More_of_Peripheral_Blood_White_Cells	Blast_Cells_Present_in_Peripheral_Blood	Blasts 20 Percent or More of Peripheral Blood White Cells|Blasts 20% or More of Peripheral Blood White Cells
C36214	Blasts_20_Percent_or_More_of_Bone_Marrow_Nucleated_Cells	Blast_Cells_Increased_in_Bone_Marrow	Blasts 20 Percent or More of Bone Marrow Nucleated Cells|Blasts 20% or More of Bone Marrow Nucleated Cells
C36215	Immature_Granulocytes_in_Peripheral_Blood_Increased	Abnormal_Hematology_Test_Result	Immature Granulocytes in Peripheral Blood Increased
C36216	Myeloblasts_Under_20_Percent_of_Bone_Marrow_Nucleated_Cells	Blasts_Under_20_Percent_of_Bone_Marrow_Nucleated_Cells	Myeloblasts Under 20 Percent of Bone Marrow Nucleated Cells|Myeloblasts Under 20% of Bone Marrow Nucleated Cells
C36217	Normoblastic_Erythroid_Hyperplasia	Erythroid_Hyperplasia	Normoblastic Erythroid Hyperplasia
C36218	Leukoerythroblastosis	Abnormal_Hematology_Test_Result	Leukoerythroblastosis
C36219	Myeloblasts_Under_10_Percent_of_Bone_Marrow_Nucleated_Cells	Blasts_Under_10_Percent_of_Bone_Marrow_Nucleated_Cells|Myeloblasts_Under_20_Percent_of_Bone_Marrow_Nucleated_Cells	Myeloblasts Under 10 Percent of Bone Marrow Nucleated Cells|Myeloblasts Under 10% of Bone Marrow Nucleated Cells
C36220	Blasts_Under_20_Percent_of_Peripheral_Blood_White_Cells	Blast_Cells_Present_in_Peripheral_Blood	Blasts Under 20 Percent of Peripheral Blood White Cells|Blasts Less than 20 Percent of Peripheral Blood White Cells|Blasts Less than 20% of Peripheral Blood White Cells|Blasts Under 20% of Peripheral Blood White Cells
C36221	Myeloblasts_Under_5_Percent_of_Peripheral_Blood_White_Cells	Myeloblasts_Under_20_Percent_of_Peripheral_Blood_White_Cells	Myeloblasts Under 5 Percent of Peripheral Blood White Cells|Myeloblasts Under 5% of Peripheral Blood White Cells
C36222	Myeloblasts_5-19_Percent_of_Peripheral_Blood_White_Cells	Blasts_5-19_Percent_of_Peripheral_Blood_White_Cells|Myeloblasts_Under_20_Percent_of_Peripheral_Blood_White_Cells	Myeloblasts 5-19 Percent of Peripheral Blood White Cells|Myeloblasts 5-19% of Peripheral Blood White Cells
C36223	Myeloblasts_Under_20_Percent_of_Peripheral_Blood_White_Cells	Blasts_Under_20_Percent_of_Peripheral_Blood_White_Cells	Myeloblasts Under 20 Percent of Peripheral Blood White Cells|Myeloblasts Under 20% of Peripheral Blood White Cells
C36224	Hemoglobin_F_Increased	Abnormal_Blood_and_Hematology_Test_Result	Hemoglobin F Increased
C36225	Ringed_Sideroblasts_Under_15_Percent_of_Erythroid_Precursors	Ringed_Sideroblasts_Present	Ringed Sideroblasts Under 15 Percent of Erythroid Precursors|Ringed Sideroblasts Under 15% of Erythroid Precursors
C36226	Ringed_Sideroblasts_15_Percent_or_More_of_Erythroid_Precursors	Ringed_Sideroblasts_Present	Ringed Sideroblasts 15 Percent or More of Erythroid Precursors|Ringed Sideroblasts 15% or More of Erythroid Precursors
C36227	Bi-Cytopenia	Cytopenia	Bi-Cytopenia
C36228	Myeloblasts_Under_1_Percent_of_Peripheral_Blood_White_Cells	Myeloblasts_Under_2_Percent_of_Peripheral_Blood_White_Cells	Myeloblasts Under 1 Percent of Peripheral Blood White Cells|Myeloblasts Under 1% of Peripheral Blood White Cells
C36229	Myeloblasts_5-19_Percent_of_Bone_Marrow_Nucleated_Cells	Myeloblasts_Under_20_Percent_of_Bone_Marrow_Nucleated_Cells	Myeloblasts 5-19 Percent of Bone Marrow Nucleated Cells|Myeloblasts 5-19% of Bone Marrow Nucleated Cells
C36230	Myeloblasts_5-9_Percent_of_Bone_Marrow_Nucleated_Cells	Myeloblasts_5-19_Percent_of_Bone_Marrow_Nucleated_Cells	Myeloblasts 5-9 Percent of Bone Marrow Nucleated Cells|Myeloblasts 5-9% of Bone Marrow Nucleated Cells
C36231	Myeloblasts_20_Percent_or_More_of_Bone_Marrow_Nucleated_Cells	Blasts_20_Percent_or_More_of_Bone_Marrow_Nucleated_Cells|Immature_Myeloid_Cells_Increased_in_Bone_Marrow	Myeloblasts 20 Percent or More of Bone Marrow Nucleated Cells|Myeloblasts 20% or More of Bone Marrow Nucleated Cells
C36232	Myeloblasts_20_Percent_or_More_of_Peripheral_Blood_White_Cells	Blasts_20_Percent_or_More_of_Peripheral_Blood_White_Cells	Myeloblasts 20 Percent or More of Peripheral Blood White Cells|Myeloblasts 20% or More of Peripheral Blood White Cells
C36233	Bone_Marrow_Eosinophilia	Abnormal_Bone_Marrow_Test_Result|Eosinophilia	Bone Marrow Eosinophilia
C36234	Peripheral_Blood_Eosinophilia	Eosinophilia	Peripheral Blood Eosinophilia
C36235	Bone_Marrow_Dysplasia_Present	Abnormal_Bone_Marrow_Test_Result	Bone Marrow Dysplasia Present
C36236	Bone_Marrow_Dysplasia_Present_in_50_Percent_or_More_of_the_Cells_of_Two_Cell_Lines	Bone_Marrow_Dysplasia_Present	Bone Marrow Dysplasia Present in 50 Percent or More of the Cells of Two Cell Lines|Bone Marrow Dysplasia Present in 50% or More of the Cells of Two Cell Lines
C36237	Bone_Marrow_Dysplasia_Present_in_10_Percent_or_More_of_the_Cells_of_Two_Cell_Lines	Bone_Marrow_Dysplasia_Present	Bone Marrow Dysplasia Present in 10 Percent or More of the Cells of Two or More Myeloid Cell Lines
C36238	Promyelocytes_Myelocytes_and_Mature_Neutrophils_10_Percent_or_More_of_Bone_Marrow_Cells	Normal_Bone_Marrow_Test_Results	Promyelocytes, Myelocytes, and Mature Neutrophils 10 Percent or More of Bone Marrow Cells|Promyelocytes, Myelocytes, and Mature Neutrophils 10% or More of Bone Marrow Cells
C36239	Neoplastic_Monocytes_and_Precursors_20_Percent_or_More_of_Bone_Marrow_Cells	Immature_Myeloid_Cells_Increased_in_Bone_Marrow	Neoplastic Monocytes and Precursors 20 Percent or More of Bone Marrow Cells|Neoplastic Monocytes and Precursors 20% or More of Bone Marrow Cells
C36240	Monoblasts_20_Percent_or_More_of_Bone_Marrow_Nucleated_Cells	Blasts_20_Percent_or_More_of_Bone_Marrow_Nucleated_Cells|Immature_Myeloid_Cells_Increased_in_Bone_Marrow	Monoblasts 20 Percent or More of Bone Marrow Nucleated Cells|Monoblasts 20% or More of Bone Marrow Nucleated Cells
C36241	Monoblasts_80_Percent_or_More_of_Bone_Marrow_Nucleated_Cells	Cells_of_Monocytic_Lineage_80_Percent_or_More_of_Bone_Marrow_Leukemic_Cells|Monoblasts_20_Percent_or_More_of_Bone_Marrow_Nucleated_Cells	Monoblasts 80 Percent or More of Bone Marrow Monocytic Cells|Monoblasts 80% or More of Bone Marrow Monocytic Cells
C36242	Neoplastic_Promonocytes_in_Bone_Marrow_Markedly_Increased	Cells_of_Monocytic_Lineage_80_Percent_or_More_of_Bone_Marrow_Leukemic_Cells	Neoplastic Promonocytes in Bone Marrow Markedly Increased
C36243	Erythroid_Precursors_50_Percent_or_More_of_Bone_Marrow_Nucleated_Cells	Immature_Myeloid_Cells_Increased_in_Bone_Marrow	Erythroid Precursors 50 Percent or More of Bone Marrow Nucleated Cells|Erythroid Precursors 50% or More of Bone Marrow Nucleated Cells
C36244	Myeloblasts_20_Percent_or_More_of_Bone_Marrow_Non-Erythroid_Cells	Myeloblasts_20_Percent_or_More_of_Bone_Marrow_Nucleated_Cells	Myeloblasts 20 Percent or More of Bone Marrow Non-Erythroid Cells|Myeloblasts 20% or More of Bone Marrow Non-Erythroid Cells
C36245	Erythroid_Precursors_80_Percent_or_More_of_Bone_Marrow_Nucleated_Cells	Erythroid_Precursors_50_Percent_or_More_of_Bone_Marrow_Nucleated_Cells	Erythroid Precursors 80 Percent or More of Bone Marrow Nucleated Cells|Erythroid Precursors 80% or More of Bone Marrow Nucleated Cells
C36246	Megakaryoblasts_50_Percent_or_More_of_Bone_Marrow_Nucleated_Cells	Immature_Myeloid_Cells_Increased_in_Bone_Marrow|Megakaryocytes_Increased	Megakaryoblasts 50 Percent or More of Bone Marrow Nucleated Cells|Megakaryoblasts 50% or More of Bone Marrow Nucleated Cells
C36247	Normal_Bone_Marrow_Test_Results	Normal_Laboratory_Test_Result	Normal Bone Marrow Test Results
C36248	Atypical_Lymphocytes_Present_in_Bone_Marrow	Abnormal_Bone_Marrow_Test_Result|Atypical_Lymphocytes_Present	Atypical Lymphocytes Present in Bone Marrow
C36249	Atypical_Lymphocytes_Present_in_Peripheral_Blood	Atypical_Lymphocytes_Present	Atypical Lymphocytes Present in Peripheral Blood
C36250	Auer_Rods_Present	Morphologic_Finding	Auer Rods Present
C36251	Benzene_Exposure	Chemical_Exposure	Benzene Exposure
C36252	Ineffective_Hematopoiesis_Present	Abnormal_Hematology_Test_Result	Ineffective Hematopoiesis
C36253	Bone_Marrow_Basophilia	Abnormal_Bone_Marrow_Test_Result|Basophilia	Bone Marrow Basophilia
C36254	Peripheral_Blood_Basophilia	Basophilia	Peripheral Blood Basophilia
C36255	Secondary_Neoplasm	Neoplasm_by_Special_Category	Secondary Neoplasm|Secondary Tumor|secondary tumor
C36256	Hematogenous_Spread	Neoplastic_Growth_or_Spread	Hematogenous Spread
C36257	Intravascular_Spread	Neoplastic_Growth_or_Spread	Intravascular Spread
C36258	Lymphatic_Spread	Neoplastic_Growth_or_Spread	Lymphatic Spread
C36259	Acute_Promyelocytic_Leukemia_with_t_15_17_q22_q12_PML_RARa	Acute_Promyelocytic_Leukemia	Acute Promyelocytic Leukemia with t(15;17)(q22;q12)(PML/RARa)|Acute Promyelocytic Leukemia with t(15;17) (q22;q12)	A type of acute myeloid leukemia, a quickly progressing disease in which too many immature blood-forming cells are found in the blood and bone marrow.
C36260	Hereditary_Conventional_Clear_Cell_Renal_Cell_Carcinoma	Conventional_Clear_Cell_Renal_Cell_Carcinoma|Hereditary_Renal_Cell_Carcinoma	Hereditary Conventional (Clear Cell) Renal Cell Carcinoma	A manifestation of von Hippel-Lindau disease or other familial renal cell cancer syndromes that present as a malignant epithelial neoplasm of the kidney.  It is characterized by the presence of lipid-containing clear cells within a vascular network.  The tumor usually is bilateral and polycentric, and metastasizes to unusual sites. Late metastasis is common.
C36261	Non-Hereditary_Conventional_Clear_Cell_Renal_Cell_Carcinoma	Conventional_Clear_Cell_Renal_Cell_Carcinoma	Non-Hereditary Conventional (Clear Cell) Renal Cell Carcinoma|Sporadic Conventional (Clear Cell) Renal Cell Carcinoma	The most common type of renal cell carcinoma, characterized by a loss of genetic material of the short arm of chromosome 3.  The most common symptom at the time of diagnosis is hematuria.  The tumor has a golden-yellow color because of the abundance of intracytoplasmic lipid.  This is a clinically aggressive type of renal cell carcinoma.  The tumor usually metastasizes to unusual sites and late metastasis is common.
C36262	Oral_Cavity_Leukoplakia	Oral_Leukoplakia	Oral Cavity Leukoplakia|Leukoplakia of Mouth|Leukoplakia of the Mouth|Mouth Leukoplakia	A white patch or plaque on oral cavity mucosa that cannot be characterized clinically or pathologically as any other disease. The diagnosis of leukoplakia is one of exclusion; other conditions such as candidiasis, lichen planus, leukoedema, etc. must be ruled out before a diagnosis of leukoplakia can be made. Leukoplakia may be a premalignant condition. --2004
C36263	Metastatic_Malignant_Neoplasm	Malignant_Neoplasm|Metastatic_Neoplasm	Metastatic Malignant Neoplasm|METC|Metastatic Cancer|metastatic cancer	A malignant tumor that has spread from its original (primary) site of growth to another site close to or distant from the primary site.--2004
C36264	Metastatic_Benign_Neoplasm	Benign_Neoplasm|Metastatic_Neoplasm	Metastatic Benign Neoplasm
C36265	Acute_Adult_T-Cell_Lymphoma_Leukemia	Adult_T-Cell_Lymphoma_Leukemia|Leukemic_Phase_of_Lymphoma	Acute Adult T-Cell Lymphoma/Leukemia	The most common variant of adult T-cell lymphoma/leukemia.  It is characterized by systemic disease with a leukemic phase, generalized lymphadenopathy, and skin lesions.  Hypercalcemia is commonly seen. -- 2004
C36266	Lymphomatous_Adult_T-Cell_Lymphoma_Leukemia	Adult_T-Cell_Lymphoma_Leukemia	Lymphomatous Adult T-Cell Lymphoma/Leukemia	An adult T-cell lymphoma/leukemia characterized by generalized lymphadenopathy without peripheral blood involvement.  Most patients have advanced disease, however hypercalcemia is not frequently present. -- 2004
C36268	Hodgkin_s-Like_Adult_T-Cell_Lymphoma_Leukemia	Adult_T-Cell_Lymphoma_Leukemia	Hodgkin's-Like Adult T-Cell Lymphoma/Leukemia
C36270	T-Cell_Prolymphocytic_Leukemia_Small_Cell_Variant	T-Cell_Prolymphocytic_Leukemia	T-Cell Prolymphocytic Leukemia, Small Cell Variant
C36271	T-Cell_Prolymphocytic_Leukemia_Cerebriform_Cell_Variant	T-Cell_Prolymphocytic_Leukemia	T-Cell Prolymphocytic Leukemia, Cerebriform Cell Variant|T-Cell Prolymphocytic Leukemia, Sezary Cell-like Variant
C36272	Chronic_Lymphocytic_Leukemia_with_Plasmacytoid_Differentiation	Chronic_Lymphocytic_Leukemia	Chronic Lymphocytic Leukemia with Plasmacytoid Differentiation
C36273	Small_Lymphocytic_Lymphoma_with_Plasmacytoid_Differentiation	Small_Lymphocytic_Lymphoma	Small Lymphocytic Lymphoma with Plasmacytoid Differentiation
C36275	Splenic_Marginal_Zone_B-Cell_Lymphoma_without_Villous_Lymphocytes	Splenic_Marginal_Zone_Lymphoma	Splenic Marginal Zone B-Cell Lymphoma without Villous Lymphocytes
C36276	Polyclonal_Polymorphic_Post-Transplant_Lymphoproliferative_Disorder	Polymorphic_Post-Transplant_Lymphoproliferative_Disorder	Polyclonal Polymorphic Post-Transplant Lymphoproliferative Disorder
C36277	Monoclonal_Polymorphic_Post-Transplant_Lymphoproliferative_Disorder	Polymorphic_Post-Transplant_Lymphoproliferative_Disorder	Monoclonal Polymorphic Post-Transplant Lymphoproliferative Disorder
C36278	Finding_by_Site_or_System	Finding	Finding by Site or System
C36279	Gastrointestinal_System_Finding	Finding_by_Site_or_System	Gastrointestinal System Finding
C36280	Nervous_System_Finding	Finding_by_Site_or_System	Nervous System Finding
C36281	Integumentary_System_Finding	Finding_by_Site_or_System	Integumentary System Finding
C36282	Head_and_Neck_Finding	Finding_by_Site_or_System	Head and Neck Finding
C36283	Eye_and_Ear_Finding	Head_and_Neck_Finding	Eye and Ear Finding
C36284	Reproductive_System_Finding	Finding_by_Site_or_System	Reproductive System Finding
C36285	Endocrine_System_Finding	Finding_by_Site_or_System	Endocrine System Finding
C36286	Urinary_Tract_Finding	Finding_by_Site_or_System	Urinary Tract Finding
C36287	Congenital_or_Acquired_Anatomic_Abnormality	Diseases_and_Disorders	Congenital or Acquired Anatomic Abnormality|Anatomic Abnormality|Anatomical Abnormality|Congenital or Acquired Anatomical Abnormality|Deformity
C36288	Connective_and_Soft_Tissue_Finding	Finding_by_Site_or_System	Connective and Soft Tissue Finding
C36289	Hematopoietic_System_Finding	Finding_by_Site_or_System	Hematopoietic System Finding
C36290	Chemical_Exposure	Finding_by_Cause	Chemical Exposure
C36291	Finding_by_Cause	Finding	Finding by Cause
C36292	Test_Result	Finding	Test Result	The outcome of a laboratory test.
C36293	Ovalocytosis	Abnormal_Hematology_Test_Result	Ovalocytosis
C36294	Neoplastic_Growth_or_Spread	Other_Finding	Neoplastic Growth or Spread|Tumor Growth or Spread
C36295	Other_Finding	Finding	Other Finding
C36296	Regional_Cancer	Retired_Concepts	Regional Cancer|regional cancer	Cancer that has grown beyond the original (primary) tumor to nearby lymph nodes or organs and tissues.
C36297	Regional_Lymph_Node_Involvement	Lymph_Node_Involvement	Regional Lymph Node Involvement
C36298	Lesion_by_Grade	Lesion|Morphologic_Finding	Lesion by Grade
C36299	Lesion_by_Stage	Lesion	Lesion by Stage
C36300	Breast_Carcinoma_Metastatic_to_the_Lung	Metastatic_Carcinoma_to_the_Lung|Stage_IV_Breast_Cancer	Breast Carcinoma Metastatic to the Lung
C36301	Breast_Carcinoma_Metastatic_to_the_Brain	Metastatic_Carcinoma|Metastatic_Neoplasm_to_the_Brain|Stage_IV_Breast_Cancer	Breast Carcinoma Metastatic to the Brain
C36302	Breast_Carcinoma_Metastatic_to_the_Liver	Metastatic_Carcinoma|Metastatic_Neoplasm_to_the_Liver|Stage_IV_Breast_Cancer	Breast Carcinoma Metastatic to the Liver
C36303	Breast_Carcinoma_Metastatic_to_the_Bone	Metastatic_Carcinoma_to_the_Bone|Stage_IV_Breast_Cancer	Breast Carcinoma Metastatic to the Bone
C36304	Lung_Carcinoma_Metastatic_to_the_Brain	Metastatic_Carcinoma|Metastatic_Neoplasm_to_the_Brain|Stage_IV_Lung_Cancer	Lung Carcinoma Metastatic to the Brain
C36305	Lung_Carcinoma_Metastatic_to_the_Bone	Metastatic_Carcinoma_to_the_Bone|Stage_IV_Lung_Cancer	Lung Carcinoma Metastatic to the Bone
C36306	Lung_Carcinoma_Metastatic_to_the_Liver	Metastatic_Carcinoma|Metastatic_Neoplasm_to_the_Liver|Stage_IV_Lung_Cancer	Lung Carcinoma Metastatic to the Liver
C36307	Prostate_Carcinoma_Metastatic_to_the_Lung	Metastatic_Carcinoma_to_the_Lung|Metastatic_Prostate_Cancer	Prostate Carcinoma Metastatic to the Lung
C36308	Prostate_Carcinoma_Metastatic_to_the_Bone	Metastatic_Carcinoma_to_the_Bone|Metastatic_Prostate_Cancer	Prostate Carcinoma Metastatic to the Bone
C36309	Colon_Carcinoma_Metastatic_to_the_Liver	Metastatic_Carcinoma|Metastatic_Neoplasm_to_the_Liver|Stage_IV_Colon_Cancer	Colon Carcinoma Metastatic to the Liver
C36310	Secondary_Carcinoma	Carcinoma|Secondary_Neoplasm	Secondary Carcinoma
C36311	Intestinal_Metaplasia_of_Esophageal_Mucosa	Esophageal_Precancerous_Condition	Intestinal Metaplasia of Esophageal Mucosa
C36312	Philadelphia_Positive_Acute_Lymphoblastic_Leukemia	Acute_Lymphoblastic_Leukemia	Philadelphia Positive Precursor Lymphoblastic Leukemia|Philadelphia Positive Acute Lymphoblastic Leukemia
C36315	Chromosomal_Loss	Numerical_Chromosome_Aberration	Chromosomal Loss	Loss of an entire chromosome or chromosome arm.
C36316	t_11_22_q24_q12	Chromosomal_Translocation	t(11;22) (q24;q12)
C36317	t_12_16_q13_p11	Chromosomal_Translocation	t(12;16)(q13;p11)
C36318	Microsatellite_Instability	Molecular_Genetic_Abnormality	Microsatellite Instability|MSI	Microsatellites are stretches of DNA in which a short motif (usually one to five nucleotides long) is repeated several times. Instability of these regions is initiated when mutations in genes that repair damaged DNA cause these regions to get longer or shorter. Hereditary colon cancer syndrome is associated with mutations in the DNA mismatch repair genes, which may result in alterations in the nucleotide sequence.
C36319	t_8_14_q24_q32	Chromosomal_Translocation	t(8;14)(q24;q32)
C36321	t_8_22_q24_q11	Chromosomal_Translocation	t(8;22)(q24;q11)
C36327	Gene_Abnormality	Molecular_Genetic_Abnormality	Gene Abnormality
C36328	RB_1Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	RB1 Gene Inactivation|Inactivation of Retinoblastoma Tumor-Suppressor Gene|RB1 Tumor-Suppressor Gene Inactivation
C36329	TP53_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	TP53 Gene Inactivation|Inactivation of p53 Tumor-Suppressor Gene|P53 Tumor-Suppressor Gene Inactivation|TP53 Tumor-Suppressor Gene Inactivation
C36330	TGFbetaRII_Tumor-Suppressor_Gene_Inactivation	Retired_Concepts	TGFbetaRII Tumor-Suppressor Gene Inactivation
C36331	Polysomy	Numerical_Chromosome_Aberration	Polysomy
C36333	Clonal_Gene_Rearrangement	Gene_Abnormality	Clonal Gene Rearrangement|Monoclonal Gene Rearrangement
C36334	Tumor-Suppressor_Gene_Inactivation	Gene_Abnormality	Tumor-Suppressor Gene Inactivation
C36335	Abnormal_DNA_Repair	Molecular_Genetic_Abnormality	Abnormal DNA Repair
C36336	Deregulation_of_Protein_and_Messenger_RNA_Expression	Molecular_Genetic_Abnormality	Deregulation of Protein and Messenger RNA Expression
C36337	Messenger_RNA_Overexpression	Deregulation_of_Protein_and_Messenger_RNA_Expression	Messenger RNA Overexpression
C36338	Deregulation_of_Apoptosis	Molecular_Genetic_Abnormality	Deregulation of Apoptosis|Deregulation of Programmed Cell Death
C36339	Cell_Cycle_Deregulation	Molecular_Genetic_Abnormality	Cell Cycle Deregulation
C36340	Molecular_Pathway_Deregulation	Molecular_Genetic_Abnormality	Molecular Pathway Deregulation
C36341	Signal_Transduction_Pathway_Deregulation	Molecular_Pathway_Deregulation	Signal Transduction Pathway Deregulation
C36342	Microsatellite_Mutation_Pathway_Deregulation	Molecular_Pathway_Deregulation	Microsatellite Mutation Pathway Deregulation
C36343	Tumor-Suppressor_Pathway_Deregulation	Molecular_Pathway_Deregulation	Tumor-Suppressor Pathway Deregulation
C36344	Oncogene_Deregulation	Gene_Abnormality	Oncogene Deregulation|Gene Deregulation
C36345	Protein_Deregulation	Deregulation_of_Protein_and_Messenger_RNA_Expression	Protein Deregulation
C36346	Fusion_Protein_Expression	Protein_Deregulation	Fusion Protein Expression
C36347	t_8_14_q24_q11	Chromosomal_Translocation	t(8;14)(q24;q11)
C36348	t_1_14_p32_q11	Chromosomal_Translocation	t(1;14)(p32;q11)
C36349	t_7_9_q34_q34_3	Chromosomal_Translocation	t(7;9)(q34;q34.3)
C36350	t_11_14_p15_q11	Chromosomal_Translocation	t(11;14)(p15;q11)
C36351	t_11_14_p13_q11	Chromosomal_Translocation	t(11;14)(p13;q11)
C36352	t_10_14_q24_q11	Chromosomal_Translocation	t(10;14)(q24;q11)
C36353	t_7_10_q34_q24	Chromosomal_Translocation	t(7;10)(q34;q24)
C36354	t_3_14_q27_q32	Chromosomal_Translocation	t(3;14)(q27;q32)
C36355	t_3_4_q27_p11	Chromosomal_Translocation	t(3;4)(q27;p11)
C36356	t_14_14_q11_q32	Chromosomal_Translocation	t(14;14)(q11;q32)
C36357	t_14_19_q32_q13_1	Chromosomal_Translocation	t(14;19)(q32;q13.1)
C36358	t_5_14_q31_q32	Chromosomal_Translocation	t(5;14)(q31;q32)
C36359	t_1_7_p33_q35	Chromosomal_Translocation	t(1;7)(p33;q35)
C36360	t_X_14_q28_11	Chromosomal_Translocation	t(X;14)(q28;11)
C36361	t_17_19_q22_p13	Chromosomal_Translocation	t(17;19)(q22;p13)
C36362	t_5_17_q32_q12	Chromosomal_Translocation	t(5;17)(q32;q12)
C36363	t_11_17_q23_q21	Chromosomal_Translocation	t(11;17)(q23;q21)
C36364	t_11_17_q13_q21	Chromosomal_Translocation	t(11;17)(q13;q21)
C36365	t_4_11_q21_q23	Chromosomal_Translocation	t(4;11)(q21;q23)
C36366	t_9_11_q21_q23	Chromosomal_Translocation	t(9;11)(q21;q23)
C36367	t_21_22_q22_q12	Chromosomal_Translocation	t(21;22)(q22;q12)
C36368	t_7_22_p22_q12	Chromosomal_Translocation	t(7;22)(p22;q12)
C36369	t_17_22_q21_q12	Chromosomal_Translocation	t(17;22)(q21;q12)
C36370	t_9_11_p22_q23	Chromosomal_Translocation	t(9;11)(p22;q23)
C36371	t_11_19_q23_p13_1	Chromosomal_Translocation	t(11;19)(q23;p13.1)
C36372	t_11_19_q23_p13_3	Chromosomal_Translocation	t(11;19)(q23;p13.3)
C36373	inv_16_p13_q22	Chromosomal_Inversion	inv(16)(p13;q22)
C36374	t_12_22_q13_q12	Chromosomal_Translocation	t(12;22)(q13;q12)
C36375	t_11_22_p13_q12	Chromosomal_Translocation	t(11;22)(p13;q12)
C36376	t_1_13_q36_q14	Chromosomal_Translocation	t(1;13)(q36;q14)
C36377	t_3_12_q27-28_q13-15	Chromosomal_Translocation	t(3;12)(q27-28;q13-15)
C36378	t_1_12_p36_q13-15	Chromosomal_Translocation	t(1;12)(p36;q13-15)
C36379	t_1_12_p32-34_q13-15	Chromosomal_Translocation	t(1;12)(p32-34;q13-15)
C36380	t_2_12_p22-24_q13-15	Chromosomal_Translocation	t(2;12)(p22-24;q13-15)
C36381	t_2_12_q35-37_q13-15	Chromosomal_Translocation	t(2;12)(q35-37;q13-15)
C36382	t_5_12_q33_q13-15	Chromosomal_Translocation	t(5;12)(q33;q13-15)
C36383	Monosomy_13	Monosomy	Monosomy 13
C36384	Monosomy_16	Monosomy	Monosomy 16
C36385	Giant_Rod_Chromosome	Chromosomal_Aberration	Giant Rod Chromosome
C36386	Aberrant_Chromosome_1	Chromosomal_Aberration	Aberrant Chromosome 1
C36387	t_12_15_p13_q26	Chromosomal_Translocation	t(12;15)(p13;q26)
C36388	t_1_2_p11_q35-36	Chromosomal_Translocation	t(1;2)(p11;q35-36)
C36389	t_2_13_q35_q14	Chromosomal_Translocation	t(2;13)(q35;q14)
C36390	t_X_18_p11_q11	Chromosomal_Translocation	t(X;18)(p11;q11)
C36391	Molecular_Genetic_Abnormality	Molecular_Abnormality	Molecular Genetic Abnormality|Anomaly|Genetic Abnormality|Genetic Alteration|Genetic Anomaly|Molecular Abnormality|Molecular Anomaly|Molecular Genetic Anomaly	Any alteration in the inherited nucleic acid sequence of the genotype of an organism.
C36392	t_X_17_p11_q25	Chromosomal_Translocation	t(X;17)(p11.2;q25)
C36393	t_9_17_q22_q11	Chromosomal_Translocation	t(9;17)(q22;q11)
C36394	t_9_15_q22_q21	Chromosomal_Translocation	t(9;15)(q22;q21)
C36396	Trisomy_8	Trisomy	Trisomy 8
C36397	Trisomy_20	Trisomy	Trisomy 20
C36398	inv_22	Chromosomal_Inversion	inv(22)
C36399	t_5_12_q33_p13	Chromosomal_Translocation	t(5;12)(q33;p13)
C36400	t_8_13_p11_q11	Chromosomal_Translocation	t(8;13)(p11;q11)
C36401	t_8_9_p11_q32-34	Chromosomal_Translocation	t(8;9)(p11;q32-34)
C36402	t_6_8_q27_p11	Chromosomal_Translocation	t(6;8)(q27;p11)
C36403	Loss_of_Chromosome_20q	Chromosomal_Loss	Loss of Chromosome 20q|del(20q)
C36406	t_3_3_q21_q26_2	Chromosomal_Translocation	t(3;3)(q21;q26.2)
C36407	inv_3_q21q26_2	Chromosomal_Inversion	inv(3)(q21q26.2)
C36408	Loss_of_Chromosome_7q	Chromosomal_Loss	Loss of Chromosome 7q|del(7q)
C36409	t_5_12_q31_p12	Chromosomal_Translocation	t(5;12)(q31;p12)
C36410	Loss_of_Chromosome_12p	Chromosomal_Loss	Loss of Chromosome 12p|del(12p)
C36411	Monosomy_7	Monosomy	Monosomy 7
C36414	ins_3_3	Chromosomal_Insertion	ins(3;3)
C36415	t_3_5_q25_q34	Chromosomal_Translocation	t(3;5)(q25;q34)
C36416	t_8_16_p11_p13	Chromosomal_Translocation	t(8;16)(p11;p13)
C36417	t_1_22_p13_q13	Chromosomal_Translocation	t(1;22)(p13;q13)
C36420	Trisomy_12	Trisomy	Trisomy 12
C36421	del_13q14	Chromosomal_Deletion	del(13q14)|del(13)(q14)
C36422	del_11q22q23	Chromosomal_Deletion	del(11q22q23)|del(11)(q22q23)
C36423	del_6q21	Chromosomal_Deletion	del(6q21)|del(6)(q21)
C36424	del_17p13	Chromosomal_Deletion	del(17p13)|del(17)(p13)
C36425	Trisomy_3	Trisomy	Trisomy 3
C36426	inv_14	Chromosomal_Inversion	inv(14)
C36427	t_8_8_p11-12_q12	Chromosomal_Translocation	t(8;8)(p11-12;q12)
C36428	Trisomy_8q	Trisomy	Trisomy 8q
C36429	del_12p13	Chromosomal_Deletion	del(12p13)|del(12)(p13)
C36430	CD95_Apoptotic_Pathway_Deregulation	Retired_Concepts	CD95 Apoptotic Pathway Deregulation
C36431	Apoptotic_Pathway_Deregulation	Molecular_Pathway_Deregulation	Apoptotic Pathway Deregulation
C36432	i_7q	Isochromosome	i(7q)|Isochromosome 7q
C36433	Trisomy_5	Trisomy	Trisomy 5
C36434	Additional_X_Chromosome	Numerical_Chromosome_Aberration	Additional X Chromosome
C36435	t_1_2_q25_p23	Chromosomal_Translocation	t(1;2)(q25;p23)
C36436	t_2_3_p23_q21	Chromosomal_Translocation	t(2;3)(p23;q21)
C36437	inv_2_p23q35	Chromosomal_Inversion	inv(2)(p23q35)
C36438	Chromosomal_Gain	Numerical_Chromosome_Aberration	Chromosomal Gain
C36439	Gain_of_Chromosome_2p	Chromosomal_Gain	Gain of Chromosome 2p
C36440	Gain_of_Chromosome_9p	Chromosomal_Gain	Gain of Chromosome 9p
C36441	Gain_of_Chromosome_12q	Chromosomal_Gain	Gain of Chromosome 12q
C36442	Clonal_BCL-2_Gene_Rearrangement	Clonal_Gene_Rearrangement	Clonal BCL2 Gene Rearrangement|Clonal BCL-2 Gene Rearrangement|Monoclonal BCL-2 Gene Rearrangement
C36443	Clonal_Immunoglobulin_Gene_Rearrangement	Clonal_Antigen_Receptor_Gene_Rearrangement	Clonal Immunoglobulin Gene Rearrangement|Monoclonal Immunoglobulin Gene Rearrangement
C36444	Clonal_Immunoglobulin_Heavy_Chain_Gene_Rearrangement	Clonal_Immunoglobulin_Gene_Rearrangement	Clonal Immunoglobulin Heavy Chain Gene Rearrangement|Monoclonal Immunoglobulin Heavy Chain Gene Rearrangement
C36445	Clonal_Immunoglobulin_Light_Chain_Gene_Rearrangement	Clonal_Immunoglobulin_Gene_Rearrangement	Clonal Immunoglobulin Light Chain Gene Rearrangement|Monoclonal Immunoglobulin Light Chain Gene Rearrangement
C36446	Clonal_T-Cell_Receptor_Gene_Rearrangement	Clonal_Antigen_Receptor_Gene_Rearrangement	Clonal T-Cell Receptor Gene Rearrangement|Monoclonal T-Cell Receptor Gene Rearrangement
C36447	Clonal_T-Cell_Receptor_Beta_Chain_Gene_Rearrangement	Clonal_T-Cell_Receptor_Gene_Rearrangement	Clonal T-Cell Receptor Beta Chain Gene Rearrangement|Monoclonal T-Cell Receptor Beta Chain Gene Rearrangement
C36448	Clonal_T-Cell_Receptor_Gamma_Chain_Gene_Rearrangement	Clonal_T-Cell_Receptor_Gene_Rearrangement	Clonal T-Cell Receptor Gamma Chain Gene Rearrangement|Monoclonal T-Cell Receptor Gamma Chain Gene Rearrangement
C36449	Clonal_BCL-6_Gene_Rearrangement	Clonal_Gene_Rearrangement	Clonal BCL6 Gene Rearrangement|Clonal BCL-6 Gene Rearrangement|Monoclonal BCL-6 Gene Rearrangement
C36450	Clonal_Antigen_Receptor_Gene_Rearrangement	Clonal_Gene_Rearrangement	Clonal Antigen Receptor Gene Rearrangement|Monoclonal Antigen Receptor Gene Rearrangement
C36451	Clonal_Immunoglobulin_Kappa_Light_Chain_Gene_Rearrangement	Clonal_Immunoglobulin_Light_Chain_Gene_Rearrangement	Clonal Immunoglobulin Kappa Light Chain Gene Rearrangement|Monoclonal Immunoglobulin Kappa Light Chain Gene Rearrangement
C36452	Clonal_Immunoglobulin_Lambda_Light_Chain_Gene_Rearrangement	Clonal_Immunoglobulin_Light_Chain_Gene_Rearrangement	Clonal Immunoglobulin Lambda Light Chain Gene Rearrangement|Monoclonal Immunoglobulin Lambda Light Chain Gene Rearrangement
C36453	Gain_of_Chromosome_7q	Chromosomal_Gain	Gain of Chromosome 7q
C36454	Gain_of_Chromosome_7	Chromosomal_Gain	Gain of Chromosome 7
C36455	Gain_of_Chromosome_8	Chromosomal_Gain	Gain of Chromosome 8
C36456	Gain_of_Chromosome_19	Chromosomal_Gain	Gain of Chromosome 19
C36457	Gain_of_Chromosome_22	Chromosomal_Gain	Gain of Chromosome 22
C36458	Gain_of_Chromosome_3	Chromosomal_Gain	Gain of Chromosome 3
C36461	Monosomy_22	Monosomy	Monosomy 22
C36463	Gain_of_Chromosome_9	Chromosomal_Gain	Gain of Chromosome 9
C36464	Gain_of_Chromosome_12	Chromosomal_Gain	Gain of Chromosome 12
C36465	Gain_of_Chromosome_15	Chromosomal_Gain	Gain of Chromosome 15
C36466	Gain_of_Chromosome_17	Chromosomal_Gain	Gain of Chromosome 17
C36467	Gain_of_Chromosome_18	Chromosomal_Gain	Gain of Chromosome 18
C36468	Monosomy_10	Monosomy	Monosomy 10
C36469	Monosomy_21	Monosomy	Monosomy 21
C36470	del_6q25	Chromosomal_Deletion	del(6q25)|del(6)(q25)
C36471	del_14q21	Chromosomal_Deletion	del(14q21)|del(14)(q21)
C36472	del_19p12	Chromosomal_Deletion	del(19p12)|del(19)(p12)
C36473	der_15_21_q10_q10	Derivative_Chromosome	der(15;21)(q10;q10)
C36474	Ring_Chromosome_1	Supernumerary_Circular_Chromosome	Ring Chromosome 1
C36475	Trisomy_6	Trisomy	Trisomy 6
C36476	Trisomy_7	Trisomy	Trisomy 7
C36477	i_17q	Isochromosome	i(17q)|Isochromosome 17q
C36478	Unbalanced_Translocation_of_Chromosome_1	Unbalanced_Chromosomal_Alteration	Unbalanced Translocation of Chromosome 1
C36480	Gain_of_Chromosome_20q	Chromosomal_Gain	Gain of Chromosome 20q
C36481	Gain_of_Chromosome_15q	Chromosomal_Gain	Gain of Chromosome 15q
C36482	Gain_of_Chromosome_1q	Chromosomal_Gain	Gain of Chromosome 1q
C36483	Gain_of_Chromosome_9q	Chromosomal_Gain	Gain of Chromosome 9q
C36484	Gain_of_Chromosome_17q	Chromosomal_Gain	Gain of Chromosome 17q
C36485	Cyclin_D1_Protein_Overexpression	Protein_Deregulation	Cyclin D1 Protein Overexpression
C36486	Gain_of_Chromosome_5	Chromosomal_Gain	Gain of Chromosome 5
C36487	Gain_of_Chromosome_3q	Chromosomal_Gain	Gain of Chromosome 3q
C36488	Gain_of_Chromosome_8q	Chromosomal_Gain	Gain of Chromosome 8q
C36489	Gain_of_Chromosome_5p	Chromosomal_Gain	Gain of Chromosome 5p
C36490	Loss_of_Chromosome_14	Chromosomal_Loss	Loss of Chromosome 14|del(14)
C36491	Loss_of_Chromosome_22	Chromosomal_Loss	Loss of Chromosome 22|del(22)
C36493	High-Frequency_Microsatellite_Instability	Microsatellite_Instability	High-Frequency Microsatellite Instability|MSI-H
C36494	Low-Frequency_Microsatellite_Instability	Microsatellite_Instability	Low-Frequency Microsatellite Instability|MSI-L
C36495	Trisomy_2	Trisomy	Trisomy 2
C36496	Loss_of_Chromosome_18q	Chromosomal_Loss	Loss of Chromosome 18q|del(18q)
C36497	Loss_of_Chromosome_13q	Chromosomal_Loss	Loss of Chromosome 13q|del(13q)
C36498	Loss_of_Chromosome_12q	Chromosomal_Loss	Loss of Chromosome 12q|del(12q)
C36499	Loss_of_Chromosome_17p	Chromosomal_Loss	Loss of Chromosome 17p|del(17p)
C36500	Loss_of_Chromosome_6p	Chromosomal_Loss	Loss of Chromosome 6p|del(6p)
C36501	Loss_of_Chromosome_1p	Chromosomal_Loss	Loss of Chromosome 1p|del(1p)
C36502	Loss_of_Chromosome_3p	Chromosomal_Loss	Loss of Chromosome 3p|del(13p
C36503	Loss_of_Chromosome_8p	Chromosomal_Loss	Loss of Chromosome 8p|del(8p)
C36504	Loss_of_Chromosome_6	Chromosomal_Loss	Loss of Chromosome 6|del(6)
C36505	Loss_of_Chromosome_11p	Chromosomal_Loss	Loss of Chromosome 11p|del(11p)
C36506	Loss_of_Chromosome_22q	Chromosomal_Loss	Loss of Chromosome 22q|del(22q)
C36507	Loss_of_Chromosome_19q	Chromosomal_Loss	Loss of Chromosome 19q|del(19q)
C36508	Monosomy_9	Monosomy	Monosomy 9
C36509	Monosomy_17	Monosomy	Monosomy 17
C36511	del_10q23	Chromosomal_Deletion	del(10q23)
C36512	Loss_of_Chromosome_10p	Chromosomal_Loss	Loss of Chromosome 10p|del(10p)
C36513	del_10q25-26	Chromosomal_Deletion	del(10q25-26)
C36514	del_5q22	Chromosomal_Deletion	del(5q22)
C36515	Loss_of_Chromosome_16q	Chromosomal_Loss	Loss of Chromosome 16q|del(16q)
C36516	Loss_of_Chromosome_10q	Chromosomal_Loss	Loss of Chromosome 10q|del(10q)
C36517	t_11_v_q23_v	Chromosomal_Translocation	t(11;v)(q23;v)
C36518	t_7_19_q34_q13	Chromosomal_Translocation	t(7;19)(q34;q13)
C36519	t_7_14_q35_q32_1	Chromosomal_Translocation	t(7;14)(q35;q32.1)
C36520	t_17_22_q22_q13	Chromosomal_Translocation	t(17;22)(q22;q13)
C36521	Partial_Trisomy_1q	Trisomy	Partial Trisomy 1q
C36522	Gain_of_Chromosome_13	Chromosomal_Gain	Gain of Chromosome 13
C36523	Monosomy_5	Monosomy	Monosomy 5
C36524	Loss_of_Chromosome_7	Chromosomal_Loss	Loss of Chromosome 7|del(7)
C36525	Gain_of_Chromosome_11	Chromosomal_Gain	Gain of Chromosome 11
C36526	Loss_of_Chromosome_5	Chromosomal_Loss	Loss of Chromosome 5|del(5)
C36527	Gain_of_Chromosome_21	Chromosomal_Gain	Gain of Chromosome 21
C36528	t_3_21_q21_q26	Chromosomal_Translocation	t(3;21)(q21;q26)
C36529	Trisomy_13	Trisomy	Trisomy 13
C36530	Trisomy_4	Trisomy	Trisomy 4
C36531	del_12p11p13	Chromosomal_Deletion	del(12p11p13)|del(12)(p11p13)
C36532	t_6_9_p23_q34	Chromosomal_Translocation	t(6;9)(p23;q34)
C36533	del_11q23	Chromosomal_Deletion	del(11q23)|del(11)(q23)
C36534	del_7q21-32	Chromosomal_Deletion	del(7q21-32)|del(7)(q21-32)
C36535	Loss_of_Chromosome_8	Chromosomal_Loss	Loss of Chromosome 8|del(8)
C36536	Loss_of_Chromosome_13	Chromosomal_Loss	Loss of Chromosome 13|del(13)
C36537	Loss_of_Chromosome_X	Chromosomal_Loss	Loss of Chromosome X|del(X)
C36538	del_6q23	Chromosomal_Deletion	del(6q23)|del(6)(q23)
C36539	Gain_of_Chromosome_X	Chromosomal_Gain	Gain of Chromosome X
C36540	Rearrangement_of_8q11-13	Chromosomal_Rearrangement	Rearrangement of 8q11-13
C36541	Chromosomal_Rearrangement	Structural_Chromosomal_Abnormality	Chromosomal Rearrangement
C36542	Loss_of_Chromosome_16	Chromosomal_Loss	Loss of Chromosome 16|del(16)
C36543	Rearrangement_of_11q13-21	Chromosomal_Rearrangement	Rearrangement of 11q13-21
C36544	Loss_of_Chromosome_17q	Chromosomal_Loss	Loss of Chromosome 17q|del(17q)
C36545	Gain_of_Chromosome_5q	Chromosomal_Gain	Gain of Chromosome 5q
C36546	Rearrangement_of_1p11-13	Chromosomal_Rearrangement	Rearrangement of 1p11-13
C36547	Loss_of_Chromosome_2p	Chromosomal_Loss	Loss of Chromosome 2p|del(2p)
C36548	Loss_of_Chromosome_2q	Chromosomal_Loss	Loss of Chromosome 2q|del(2q)
C36549	Loss_of_Chromosome_11	Chromosomal_Loss	Loss of Chromosome 11|del(11)
C36550	Gain_of_Chromosome_7p	Chromosomal_Gain	Gain of Chromosome 7p
C36551	Gain_of_Chromosome_7q32	Chromosomal_Gain	Gain of Chromosome 7q32
C36552	Gain_of_Chromosome_1p31	Chromosomal_Gain	Gain of Chromosome 1p31
C36553	Gain_of_Chromosome_1q21-31	Chromosomal_Gain	Gain of Chromosome 1q21-31
C36554	del_3p21-23	Chromosomal_Deletion	del(3p21-23)|del(3)(p21-23)
C36555	del_8p21-pter	Chromosomal_Deletion	del(8p21-pter)
C36556	del_13q12-13	Chromosomal_Deletion	del(13q12-13)
C36557	del_13q32-qter	Chromosomal_Deletion	del(13q32-qter)
C36558	Gain_of_Chromosome_1	Chromosomal_Gain	Gain of Chromosome 1
C36559	Gain_of_Chromosome_20	Chromosomal_Gain	Gain of Chromosome 20
C36560	del_11p15	Chromosomal_Deletion	del(11p15)
C36561	Rearrangement_of_1p11-q11	Chromosomal_Rearrangement	Rearrangement of 1p11-q11
C36562	Rearrangement_of_12q13	Chromosomal_Rearrangement	Rearrangement of 12q13
C36563	t_1_3_p36_3_q25	Chromosomal_Translocation	t(1;3)(p36.3;q25)
C36564	i_8_q10	Isochromosome	i(8)(q10)
C36565	del_8q24_1	Chromosomal_Deletion	del(8q24.1)
C36566	Rearrangement_of_8q21	Chromosomal_Rearrangement	Rearrangement of 8q21
C36567	Rearrangement_of_6q13	Chromosomal_Rearrangement	Rearrangement of 6q13
C36568	Rearrangement_of_6q25	Chromosomal_Rearrangement	Rearrangement of 6q25
C36569	del_1p36	Chromosomal_Deletion	del(1p36)
C36570	del_1p13-22	Chromosomal_Deletion	del(1p13-22)
C36571	Loss_of_Chromosome_4	Chromosomal_Loss	Loss of Chromosome 4|del(4)
C36572	del_5q13-31	Chromosomal_Deletion	del(5q13-31)
C36573	del_6q22-qter	Chromosomal_Deletion	del(6q22-qter)
C36574	del_9p22-pter	Chromosomal_Deletion	del(9p22-pter)
C36575	del_10q24-qter	Chromosomal_Deletion	del(10q24-qter)
C36576	del_11p13-pter	Chromosomal_Deletion	del(11p13-pter)
C36577	del_11q25	Chromosomal_Deletion	del(11q25)
C36578	del_13q21-qter	Chromosomal_Deletion	del(13q21-qter)
C36579	Loss_of_Chromosome_18p	Chromosomal_Loss	Loss of Chromosome 18p|del(18p)
C36580	del_22q13	Chromosomal_Deletion	del(22q13)
C36581	Gain_of_Chromosome_7p13-pter	Chromosomal_Gain	Gain of Chromosome 7p13-pter
C36582	Gain_of_Chromosome_12q15-qter	Chromosomal_Gain	Gain of Chromosome 12q15-qter
C36583	Loss_of_Chromosome_6q	Chromosomal_Loss	Loss of Chromosome 6q|del(6q)
C36584	Loss_of_Chromosome_9	Chromosomal_Loss	Loss of Chromosome 9|del(9)
C36585	Loss_of_Chromosome_10	Chromosomal_Loss	Loss of Chromosome 10|del(10)
C36586	Loss_of_Chromosome_3	Chromosomal_Loss	Loss of Chromosome 3|del(3)
C36587	Rearrangement_of_17p	Chromosomal_Rearrangement	Rearrangement of 17p11-13
C36588	t_14_18_q32_q11	Chromosomal_Translocation	t(14;18)(q32;q11)
C36589	t_1_2_p22_p12	Chromosomal_Translocation	t(1;2)(p22;p12)
C36590	t_2_17_p23_q23	Chromosomal_Translocation	t(2;17)(p23;q23)
C36591	t_X_2_q11-12_p23	Chromosomal_Translocation	t(X;2)(q11-12;p23)
C36592	Gain_of_Chromosome_9q34	Chromosomal_Gain	Gain of Chromosome 9q34
C36593	Increased_NFkappaB_Pathway_Activation	Signal_Transduction_Pathway_Deregulation	Increased NFkappaB Pathway Activation
C36594	del_6q21q25	Chromosomal_Deletion	del(6q21q25)|del(6)(q21q25)
C36595	Loss_of_Chromosome_16p	Chromosomal_Loss	Loss of Chromosome 16p|del(16p)
C36596	Gain_of_Chromosome_6q	Chromosomal_Gain	Gain of Chromosome 6q
C36597	Loss_of_Chromosome_1	Chromosomal_Loss	Loss of Chromosome 1|del(1)
C36598	Loss_of_Chromosome_18	Chromosomal_Loss	Loss of Chromosome 18|del(18)
C36599	Loss_of_Chromosome_Y	Chromosomal_Loss	Loss of Chromosome Y|del(Y)
C36600	Tetrasomy_12	Tetrasomy	Tetrasomy 12
C36601	Tetrasomy	Numerical_Chromosome_Aberration	Tetrasomy
C36602	inv_14_q11_q32_1	Chromosomal_Inversion	inv(14)(q11;q32.1)
C36603	t_7_9_q34_q32	Chromosomal_Translocation	t(7;9)(q34;q32)
C36604	del_9p21p22	Chromosomal_Deletion	del(9p21p22)|del(9)(p21p22)
C36605	i_19	Isochromosome	i(19)
C36606	t_3_21_q26_q22	Chromosomal_Translocation	t(3;21)(q26;q22)
C36607	t_12_22_p13_q11	Chromosomal_Translocation	t(12;22)(p13;q11)
C36608	inv_11_p15q22	Chromosomal_Inversion	inv(11)(p15q22)
C36609	t_7_11_p15_p15	Chromosomal_Translocation	t(7;11)(p15;p15)
C36610	t_6_11_q27_q23	Chromosomal_Translocation	t(6;11)(q27;q23)
C36611	t_10_11_p11_q23	Chromosomal_Translocation	t(10;11)(p11;q23)
C36612	del_16q22	Chromosomal_Deletion	del(16q22)|del(16)(q22)
C36613	t_1_21_p36_q22	Chromosomal_Translocation	t(1;21)(p36;q22)
C36614	t_5_21_q13_q22	Chromosomal_Translocation	t(5;21)(q13;q22)
C36615	t_17_21_q11_q22	Chromosomal_Translocation	t(17;21)(q11;q22)
C36616	t_16_21_p11_q22	Chromosomal_Translocation	t(16;21)(p11;q22)
C36620	del_7q31_1	Chromosomal_Deletion	del(7q31.1)
C36621	del_8p22	Chromosomal_Deletion	del(8p22)
C36622	del_8p12p21	Chromosomal_Deletion	del(8p12p21)|del(8)(p12p21)
C36623	del_10q24q25	Chromosomal_Deletion	del(10q24q25)|del (10)(q24q25)
C36625	del_16q23-24_2	Chromosomal_Deletion	del(16q23-24.2)|del(16)(q23-24.2)
C36626	Trisomy_18	Trisomy	Trisomy 18
C36627	Monosomy_6	Monosomy	Monosomy 6
C36628	Monosomy_8	Monosomy	Monosomy 8
C36629	Monosomy_11	Monosomy	Monosomy 11
C36630	Monosomy_X	Monosomy	Monosomy X
C36631	Loss_of_Chromosome_17	Chromosomal_Loss	Loss of Chromosome 17|del(17)
C36632	Loss_of_Chromosome_19	Chromosomal_Loss	Loss of Chromosome 19|del(19)
C36633	Gain_of_Chromosome_6p	Chromosomal_Gain	Gain of Chromosome 6p
C36634	Gain_of_Chromosome_17q22-q24	Chromosomal_Gain	Gain of Chromosome 17q22-q24
C36635	Gain_of_Chromosome_20q13	Chromosomal_Gain	Gain of Chromosome 20q13
C36636	Loss_of_Chromosome_9p	Chromosomal_Loss	Loss of Chromosome 9p|del(9p)
C36637	Gain_of_Chromosome_19q	Chromosomal_Gain	Gain of Chromosome 19q
C36638	ERBB2_Gene_Amplification	Oncogene_Deregulation	c-erbB2 Gene Amplification|ERBB2 Gene Amplification|HER-2 Gene Amplification|c-erbB2 Gene Activation
C36639	c-erbB2_Protein_Overexpression	Protein_Deregulation	ERBB2 Protein Overexpression
C36640	c-erbB2_Messenger_RNA_Overexpression	Messenger_RNA_Overexpression	c-erbB2 Messenger RNA Overexpression
C36641	c-myc_Gene_Amplification	c-myc_Gene_Mutation	MYC Gene Amplification|c-myc Gene Activation|c-myc Gene Amplification
C36642	Cyclin_D1_Messenger_RNA_Overexpression	Messenger_RNA_Overexpression	Cyclin D1 Messenger RNA Overexpression|CCND1 Gene Overexpression|CCND1 mRNA Overexpression|Cyclin D1 Gene Overexpression|Cyclin D1 mRNA Overexpression
C36643	Cyclin_E_Protein_Overexpression	Protein_Deregulation	Cyclin E Protein Overexpression
C36644	Loss_of_E-cadherin_Expression	Protein_Deregulation	Loss of E-cadherin Expression
C36645	Loss_of_Chromosome_3p_FHIT_Gene_Locus	Chromosomal_Deletion	Loss of Chromosome 3p FHIT Gene Locus
C36646	Loss_of_Chromosome_11q_ATM_Gene_Locus	Chromosomal_Deletion	Loss of Chromosome 11q ATM Gene Locus
C36647	i_1_q10	Isochromosome	i(1)(q10)
C36648	der_1_16_q10_p10	Unbalanced_Chromosomal_Alteration	der(1;16)(q10;p10)
C36649	EGFR_Gene_Amplification	Oncogene_Deregulation	EGFR Gene Amplification|EGFR Gene Activation|Epidermal Growth Factor Receptor Gene Activation|Epidermal Growth Factor Receptor Gene Amplification|c-erbB1 Gene Amplification
C36650	FGFR1_Gene_Amplification	Oncogene_Deregulation	FGFR1 Gene Amplification|FGFR1 Gene Activation|Fibroblast Growth Factor Receptor 1 Gene Activation|Fibroblast Growth Factor Receptor 1 Gene Amplification
C36651	FGFR_2_Gene_Amplification	Oncogene_Deregulation	FGFR2 Gene Amplification|BEK Gene Amplification|FGFR2 Gene Activation|Fibroblast Growth Factor Receptor 2 Gene Activation|Fibroblast Growth Factor Receptor 2 Gene Amplification
C36652	CCND1_Gene_Amplification	Oncogene_Deregulation	CCND1 Gene Amplification|CCND1 Gene Activation|Cyclin D1 Gene Activation|Cyclin D1 Gene Amplification
C36653	IGF2R_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	IGF2R Gene Inactivation|IGF2R Tumor-Suppressor Gene Inactivation
C36654	CDH1_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	CDH1 Gene Inactivation|CDH1 Tumor-Suppressor Gene Inactivation|E-CAD Tumor-Suppressor Gene Inactivation
C36655	Polysomy_3	Polysomy	Polysomy 3
C36656	Polysomy_10	Polysomy	Polysomy 10
C36657	Polysomy_17	Polysomy	Polysomy 17
C36658	Gain_of_Chromosome_Xq	Chromosomal_Gain	Gain of Chromosome Xq
C36659	Beta_Catenin_Gene_Mutation	Gene_Abnormality	CTNNB1 Gene Mutation|Beta Catenin Gene Mutation
C36660	Monoclonal_Hepatocyte_Population	Clonal_Cellular_Population_Present	Monoclonal Hepatocyte Population Present|Clonal Hepatocyte Population Present
C36661	Growth_Factor_Overexpression	Abnormal_Laboratory_Test	Growth Factor Overexpression
C36662	Transforming_Growth_Factor-Beta_Overexpression	Growth_Factor_Overexpression	Transforming Growth Factor-Beta Overexpression
C36663	Fibroblast_Growth_Factor_2_Overexpression	Growth_Factor_Overexpression	Fibroblast Growth Factor 2 Overexpression|Basic Fibroblast Growth Factor Overexpression|bFGF Overexpression
C36664	Aberrant_DNA_Methylation	Molecular_Genetic_Abnormality	Aberrant DNA Methylation
C36665	KRAS_Gene_Amplification	KRAS_Gene_Mutation	KRAS2 Gene Amplification|KRAS Gene Activation|KRAS Gene Amplification|c-K-ras Gene Amplification
C36666	Fibroblast_Growth_Factor_1_Overexpression	Growth_Factor_Overexpression	Fibroblast Growth Factor 1 Overexpression|Acidic Fibroblast Growth Factor Overexpression|aFGF Overexpression
C36667	Loss_of_Chromosome_4q	Chromosomal_Loss	Loss of Chromosome 4q|del(4q)
C36669	Gain_of_Chromosome_6	Chromosomal_Gain	Gain of Chromosome 6
C36670	Gain_of_Chromosome_16	Chromosomal_Gain	Gain of Chromosome 16
C36671	Gain_of_Chromosome_10	Chromosomal_Gain	Gain of Chromosome 10
C36672	v-fos_Gene_Amplification	Retired_Concepts	FOS Gene Amplification|v-fos Gene Amplification
C36673	N-myc_Gene_Amplification	Oncogene_Deregulation	NMYC Gene Amplification|N-myc Gene Amplification
C36675	L-myc_Gene_Amplification	Oncogene_Deregulation	LMYC Gene Amplification|L-myc Gene Amplification
C36676	c-erbB1_Gene_Amplification	Retired_Concepts	c-erbB1 Gene Amplification
C36678	c-fos_Gene_Amplification	Oncogene_Deregulation	FOS Gene Amplification|c-fos Gene Amplification|v-fos Gene Amplification
C36679	HRAS_Gene_Amplification	HRAS_Gene_Mutation	HRAS Gene Amplification|c-H-ras Gene Amplification
C36680	MYB_Gene_Amplification	Oncogene_Deregulation	MYB Gene Amplification
C36681	MDM2_Gene_Amplification	MDM2_Gene_Mutation	MDM2 Gene Amplification|Mouse Double Minute 2 Gene Amplification
C36682	CCNE_Gene_Amplification	Oncogene_Deregulation	CCNE1 Gene Amplification
C36683	APC_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	APC Gene Inactivation|APC Tumor-Suppressor Gene Inactivation
C36684	WT-1_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	WT1 Gene Inactivation|WT-1 Tumor-Suppressor Gene Inactivation|WT1 Tumor-Suppressor Gene Inactivation
C36685	NF-1_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	NF1 Gene Inactivation|NF-1 Tumor-Suppressor Gene Inactivation|NF1 Tumor-Suppressor Gene Inactivation
C36686	NF-2_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	NF2 Gene Inactivation|NF-2 Tumor-Suppressor Gene Inactivation|NF2 Tumor-Suppressor Gene Inactivation
C36687	VHL_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	VHL Gene Inactivation|VHL Tumor-Suppressor Gene Inactivation
C36688	BRCA1_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	BRCA1 Gene Inactivation|BRCA1 Tumor-Suppressor Gene Inactivation
C36689	BRCA2_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	BRCA2 Gene Inactivation|BRCA2 Tumor-Suppressor Gene Inactivation
C36690	MEN-1_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	MEN1 Gene Inactivation|MEN-1 Tumor-Suppressor Gene Inactivation|MEN1 Tumor-Suppressor Gene Inactivation
C36691	PTCH_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	PTCH Gene Inactivation|PTCH Tumor-Suppressor Gene Inactivation
C36692	PTEN_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	PTEN Gene Inactivation|PTEN Tumor-Suppressor Gene Inactivation
C36693	DPC4_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	SMAD4/DPC4 Gene Inactivation|DPC4 Tumor-Suppressor Gene Inactivation|MADH4 Gene Inactivation|MADH4 Tumor-Suppressor Gene Inactivation|SMAD4 Gene Inactivation
C36694	E-CAD_Tumor-Suppressor_Gene_Inactivation	Retired_Concepts	CDH1 Gene Inactivation|CDH1 Tumor-Suppressor Gene Inactivation|E-CAD Tumor-Suppressor Gene Inactivation
C36695	LKB1_STK1_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	LKB1 Gene Inactivation|LKB1 Tumor-Suppressor Gene Inactivation|STK11 Gene Inactivation|STK11 Tumor-Suppressor Gene Inactivation
C36696	TSC2_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	TSC2 Gene Inactivation|TSC2 Tumor-Suppressor Gene Inactivation
C36697	hMSH2_Mismatch_Repair_Gene_Inactivation	Mismatch_Repair_Gene_Inactivation	MSH2 Gene Inactivation|hMSH2 Mismatch Repair Gene Inactivation
C36698	hMLH1_Mismatch_Repair_Gene_Inactivation	Mismatch_Repair_Gene_Inactivation	MLH1 Gene Inactivation|hMLH1 Mismatch Repair Gene Inactivation
C36699	Mismatch_Repair_Gene_Inactivation	Gene_Abnormality	Mismatch Repair Gene Inactivation
C36700	TGF-beta_RII_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	TGFBR2 Gene Inactivation|TGF-beta RII Tumor-Suppressor Gene Inactivation|TGF-beta Receptor Type II Tumor-Suppressor Gene Inactivation|TGFBR2 Tumor-Suppressor Gene Inactivation|TGFbetaRII Tumor-Suppressor Gene Inactivation
C36701	hMSH6_Mismatch_Repair_Gene_Inactivation	Mismatch_Repair_Gene_Inactivation	MSH6 Gene Inactivation|hMSH6 Mismatch Repair Gene Inactivation
C36702	PMS1_Mismatch_Repair_Gene_Inactivation	Mismatch_Repair_Gene_Inactivation	PMS1 Gene Inactivation|PMS1 Mismatch Repair Gene Inactivation
C36703	PMS2_Mismatch_Repair_Gene_Inactivation	Mismatch_Repair_Gene_Inactivation	PMS2 Gene Inactivation|PMS2 Mismatch Repair Gene Inactivation
C36704	FHIT_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	FHIT Gene Inactivation|FHIT Tumor-Suppressor Gene Inactivation
C36706	NPM-ALK_Fusion_Protein_Expression	Fusion_Protein_Expression	NPM-ALK Fusion Protein Expression
C36707	TPM3-ALK_Fusion_Protein_Expression	Fusion_Protein_Expression	TPM3-ALK Fusion Protein Expression
C36708	TFG-ALK_Fusion_Protein_Expression	Fusion_Protein_Expression	TFG-ALK Fusion Protein Expression
C36709	TFG-ALKshort_Fusion_Protein_Expression	TFG-ALK_Fusion_Protein_Expression	TFG-ALKshort Fusion Protein Expression
C36710	TFG-ALKlong_Fusion_Protein_Expression	TFG-ALK_Fusion_Protein_Expression	TFG-ALKlong Fusion Protein Expression
C36711	ATIC-ALK_Fusion_Protein_Expression	Fusion_Protein_Expression	ATIC-ALK Fusion Protein Expression
C36712	p210_Fusion_Protein_Expression	BCR-ABL_Fusion_Protein_Expression	p210 Fusion Protein Expression
C36713	p230_Fusion_Protein_Expression	BCR-ABL_Fusion_Protein_Expression	p230 Fusion Protein Expression
C36714	p190_Fusion_Protein_Expression	BCR-ABL_Fusion_Protein_Expression	p190 Fusion Protein Expression
C36715	BCR-ABL_Fusion_Protein_Expression	Fusion_Protein_Expression	BCR-ABL1 Fusion Protein Expression
C36716	LE_Cell	Abnormal_Cell	LE Cell|Lupus Erythematosus Cell
C36717	Sickle_Cell	Abnormal_Red_Blood_Cell	Sickle Cell
C36718	Sideroblast	Abnormal_Erythroblast	Sideroblast
C36719	Segmented_Neutrophil	Abnormal_Neutrophil	Segmented Neutrophil
C36720	Malignant_Neuroendocrine_Fusiform_Small_Cell	Malignant_Neuroendocrine_Small_Cell	Malignant Neuroendocrine Fusiform Small Cell|Intermediate Small Cell
C36721	Pelger-Huet_Cell	Abnormal_Neutrophil	Pelger-Huet Cell
C36722	Sezary_Cell	Cerebriform_Lymphocyte|Leukemic_Lymphocyte	Sezary Cell|Cerebriform Lymphocyte
C36723	Giant_Platelet	Abnormal_Platelet	Giant Platelet
C36724	Neutrophil_with_Pseudo_Pelger-Huet_Nucleus	Dysplastic_Neutrophil	Neutrophil with Pseudo Pelger-Huet Nucleus
C36725	Abnormal_Lymphocyte	Abnormal_Hematopoietic_Cell	Abnormal Lymphocyte
C36726	Tear-Drop_Red_Blood_Cell	Abnormal_Red_Blood_Cell	Tear-Drop Red Blood Cell|Dacrocyte
C36731	Guacher_s_Cell	Abnormal_Macrophage	Guacher's Cell|Guacher Cells
C36732	Touton_Giant_Cell	Giant_Cell	Touton Giant Cell
C36733	Sea-Blue_Histiocyte	Abnormal_Macrophage	Sea-Blue Histiocyte
C36734	Anaplastic_Cell	Neoplastic_Large_Cell	Anaplastic Cell
C36735	Cytomegalic_Cell	Abnormal_Cell	Cytomegalic Cell
C36736	Downey_Cell	Abnormal_Lymphocyte	Downey Cell
C36737	Lepra_Cell	Abnormal_Macrophage	Lepra Cell|Lepra Cells
C36738	Mikulicz_Cell	Abnormal_Macrophage	Mikulicz Cell
C36739	Physaliphorous_Cell	Malignant_Connective_and_Soft_Tissue_Cell	Physaliphorous Cell|Physalipherous Cell
C36740	Pseudoxanthoma_Cell	Abnormal_Macrophage	Pseudoxanthoma Cell
C36741	Raji_Cell	Neoplastic_B-Lymphocyte	Raji Cell
C36742	Spider_Cell	Neoplastic_Striated_Muscle_Cell	Spider Cell
C36743	Centrocyte	Neoplastic_Follicle_Center_Cell	Neoplastic Centrocyte
C36744	Rhabdomyoblast	Neoplastic_Striated_Muscle_Cell	Rhabdomyoblast
C36745	Abnormal_Epithelial_Cell	Abnormal_Cell	Abnormal Epithelial Cell
C36746	Dyskeratotic_Keratinocyte	Abnormal_Keratinocyte|Dyskeratotic_Cell	Dyskeratotic Keratinocyte
C36747	Acantholytic_Keratinocyte	Abnormal_Keratinocyte	Acantholytic Keratinocyte
C36748	Multinucleated_Keratinocyte	Abnormal_Keratinocyte|Atypical_Squamous_Cell|Giant_Epithelial_Cell	Multinucleated Keratinocyte
C36749	Neoplastic_Keratinocyte	Abnormal_Keratinocyte|Neoplastic_Squamous_Cell	Neoplastic Keratinocyte
C36750	Large_Keratinocyte	Neoplastic_Keratinocyte	Large Keratinocyte
C36751	Balloon_Epithelial_Cell	Abnormal_Epithelial_Cell	Balloon Epithelial Cell
C36752	Castration_Cell	Abnormal_Glandular_Cell|Signet_Ring_Cell	Castration Cell
C36753	Neoplastic_Epithelial_Cell	Abnormal_Epithelial_Cell|Neoplastic_Cell	Neoplastic Epithelial Cell
C36754	Paget_s_Cell	Adenocarcinoma_Cell	Paget's Cell
C36755	Bowenoid_Cell	Neoplastic_Epithelial_Cell	Bowenoid Cell
C36756	Neoplastic_Epithelial_Clear_Cell	Neoplastic_Clear_Cell|Neoplastic_Epithelial_Cell	Neoplastic Epithelial Clear Cell
C36757	Neoplastic_Clear_Cell	Neoplastic_Cell	Neoplastic Clear Cell
C36758	Neoplastic_Hobnail_Cell	Neoplastic_Glandular_Cell	Neoplastic Hobnail Cell
C36759	Neoplastic_Basal_Cell	Neoplastic_Epithelial_Cell	Neoplastic Basal Cell
C36760	Neoplastic_Squamous_Cell	Abnormal_Squamous_Cell|Neoplastic_Epithelial_Cell	Neoplastic Squamous Cell
C36761	Neoplastic_Neuroendocrine_Cell	Neoplastic_Endocrine_Cell	Neoplastic Neuroendocrine Cell
C36762	Oat_Cell	Malignant_Neuroendocrine_Small_Cell	Oat Cell
C36763	Neoplastic_Glandular_Cell	Abnormal_Glandular_Cell|Neoplastic_Epithelial_Cell	Neoplastic Glandular Cell
C36764	Abnormal_Glandular_Cell	Abnormal_Epithelial_Cell	Abnormal Glandular Cell
C36765	Neoplastic_Glandular_Cell_with_Clear_Cytoplasm	Neoplastic_Glandular_Cell	Neoplastic Glandular Cell with Clear Cytoplasm
C36766	Abnormal_Keratinocyte	Abnormal_Squamous_Cell	Abnormal Keratinocyte
C36767	Abnormal_Transitional_Cell	Abnormal_Epithelial_Cell	Abnormal Transitional Cell
C36768	Neoplastic_Transitional_Cell	Abnormal_Transitional_Cell|Neoplastic_Epithelial_Cell	Neoplastic Transitional Cell
C36769	Abnormal_Myoepithelial_Cell	Abnormal_Cell	Abnormal Myoepithelial Cell
C36770	Neoplastic_Myoepithelial_Cell	Abnormal_Myoepithelial_Cell|Neoplastic_Epithelial_Cell	Neoplastic Myoepithelial Cell
C36771	Malignant_Squamous_Cell	Malignant_Epithelial_Cell|Neoplastic_Squamous_Cell	Malignant Squamous Cell
C36772	Abnormal_Squamous_Cell	Abnormal_Epithelial_Cell	Abnormal Squamous Cell
C36773	Adenocarcinoma_Cell	Malignant_Epithelial_Cell|Neoplastic_Glandular_Cell	Adenocarcinoma Cell|Malignant Glandular Cell
C36774	Multinucleated_Malignant_Squamous_Cell	Malignant_Epithelial_Giant_Cell|Malignant_Squamous_Cell	Multinucleated Malignant Squamous Cell
C36775	Malignant_Spindle_Squamous_Cell	Malignant_Epithelial_Spindle_Cell|Malignant_Squamous_Cell	Malignant Spindle Squamous Cell
C36776	Malignant_Tadpole_Squamous_Cell	Malignant_Squamous_Cell	Malignant Tadpole Squamous Cell
C36777	Signet_Ring_Adenocarcinoma_Cell	Mucin-Producing_Adenocarcinoma_Cell|Signet_Ring_Cell	Signet Ring Adenocarcinoma Cell|Signet Ring Malignant Glandular Cell
C36778	Malignant_Transitional_Cell	Malignant_Epithelial_Cell|Neoplastic_Transitional_Cell	Malignant Transitional Cell
C36779	Malignant_Epithelial_Cell	Malignant_Cell|Neoplastic_Epithelial_Cell	Malignant Epithelial Cell|Carcinoma Cell
C36780	Malignant_Myoepithelial_Cell	Malignant_Epithelial_Cell|Neoplastic_Myoepithelial_Cell	Malignant Myoepithelial Cell
C36781	Neoplastic_Cutaneous_Basal_Cell	Neoplastic_Basal_Cell	Neoplastic Cutaneous Basal Cell
C36782	Neoplastic_Non-Cutaneous_Basal_Cell	Neoplastic_Basal_Cell|Neoplastic_Glandular_Cell	Neoplastic Non-Cutaneous Basal Cell
C36783	Non-Cutaneous_Malignant_Basal_Cell	Adenocarcinoma_Cell|Neoplastic_Non-Cutaneous_Basal_Cell	Non-Cutaneous Malignant Basal Cell
C36784	Malignant_Epithelial_Clear_Cell	Malignant_Epithelial_Cell|Neoplastic_Epithelial_Clear_Cell	Malignant Epithelial Clear Cell
C36785	Atypical_Reparative_Cell	Atypical_Epithelial_Cell|Reactive_Epithelial_Cell	Atypical Reparative Cell|ARC
C36786	Metaplastic_Cell	Abnormal_Cell	Metaplastic Cell
C36787	Atypical_Parabasal_Cell	Atypical_Epithelial_Cell	Atypical Parabasal Cell
C36788	Giant_Epithelial_Cell	Atypical_Epithelial_Cell|Giant_Cell	Giant Epithelial Cell|Multinucleated Epithelial Cell
C36789	Dysplastic_Squamous_Cell	Dysplastic_Epithelial_Cell|Neoplastic_Squamous_Cell	Dysplastic Squamous Cell
C36790	Non-Keratinizing_Malignant_Small_Squamous_Cell	Non-Keratinizing_Malignant_Squamous_Cell	Non-Keratinizing Malignant Small Squamous Cell|Poorly Differentiated Squamous Cell
C36791	Keratinizing_Malignant_Squamous_Cell	Malignant_Squamous_Cell	Keratinizing Malignant Squamous Cell|Well Differentiated Malignant Squamous Cell
C36792	Non-Keratinizing_Malignant_Squamous_Cell	Malignant_Squamous_Cell	Non-Keratinizing Malignant Squamous Cell
C36793	Non-Keratinizing_Malignant_Large_Squamous_Cell	Non-Keratinizing_Malignant_Squamous_Cell	Non-Keratinizing Malignant Large Squamous Cell|Moderately Differentiated Malignant Squamous Cell
C36794	Dysplastic_Glandular_Cell	Dysplastic_Epithelial_Cell|Neoplastic_Glandular_Cell	Dysplastic Glandular Cell
C36795	Malignant_Epithelial_Small_Cell	Malignant_Epithelial_Cell|Malignant_Small_Cell	Malignant Epithelial Small Cell
C36796	Well_Differentiated_Adenocarcinoma_Cell	Adenocarcinoma_Cell	Well Differentiated Adenocarcinoma Cell|Well Differentiated Malignant Glandular Cell
C36797	Moderately_Differentiated_Adenocarcinoma_Cell	Adenocarcinoma_Cell	Moderately Differentiated Adenocarcinoma Cell|Moderately Differentiated Malignant Glandular Cell
C36798	Poorly_Differentiated_Adenocarcinoma_Cell	Adenocarcinoma_Cell	Poorly Differentiated Adenocarcinoma Cell|Poorly Differentiated Malignant Glandular Cell
C36799	Abnormal_Trophoblastic_Cell	Abnormal_Epithelial_Cell	Abnormal Trophoblastic Cell
C36800	Abnormal_Syncytiotrophoblastic_Cell	Abnormal_Trophoblastic_Cell	Abnormal Syncytiotrophoblastic Cell
C36801	Abnormal_Cytotrophoblastic_Cell	Abnormal_Trophoblastic_Cell	Abnormal Cytotrophoblastic Cell
C36802	Abnormal_Intermediate_Type_Trophoblastic_Cell	Abnormal_Trophoblastic_Cell	Abnormal Intermediate Type Trophoblastic Cell|Atypical Intermediate Type Trophoblastic Cell
C36803	Neoplastic_Trophoblastic_Cell	Abnormal_Trophoblastic_Cell|Neoplastic_Epithelial_Cell	Neoplastic Trophoblastic Cell
C36804	Postradiation_Dysplastic_Epithelial_Cell	Dysplastic_Epithelial_Cell	Postradiation Dysplastic Epithelial Cell
C36805	Postradiation_Dysplastic_Glandular_Cell	Dysplastic_Glandular_Cell|Postradiation_Dysplastic_Epithelial_Cell	Postradiation Dysplastic Glandular Cell
C36806	Postradiation_Dysplastic_Squamous_Cell	Dysplastic_Squamous_Cell|Postradiation_Dysplastic_Epithelial_Cell	Postradiation Dysplastic Squamous Cell
C36807	Dysplastic_Epithelial_Cell	Neoplastic_Epithelial_Cell	Dysplastic Epithelial Cell
C36808	Koilocytotic_Squamous_Cell	Atypical_Squamous_Cell	Koilocytotic Squamous Cell|Koilocyte
C36809	Reactive_Epithelial_Cell	Abnormal_Epithelial_Cell	Reactive Epithelial Cell
C36810	Reactive_Squamous_Cell	Abnormal_Squamous_Cell|Reactive_Epithelial_Cell	Reactive Squamous Cell
C36811	Reactive_Glandular_Cell	Abnormal_Glandular_Cell|Reactive_Epithelial_Cell	Reactive Glandular Cell
C36812	Warthin-Finkeldey_Polykaryocyte	Abnormal_Lymphocyte|Giant_Cell	Warthin-Finkeldey Polykaryocyte
C36813	Multinucleated_Reed-Sternberg_Cell	Classical_Reed-Sternberg_Cell|Neoplastic_Multinucleated_Giant_Cell	Multinucleated Reed-Sternberg Cell|Multinucleated Reed Sternberg Cell
C36814	Malignant_Clear_Squamous_Cell	Malignant_Epithelial_Clear_Cell|Malignant_Squamous_Cell	Malignant Clear Squamous Cell
C36815	Adenocarcinoma_Clear_Cell	Adenocarcinoma_Cell|Malignant_Epithelial_Clear_Cell|Neoplastic_Glandular_Cell_with_Clear_Cytoplasm	Adenocarcinoma Clear Cell|Malignant Glandular Clear Cell
C36816	Metaplastic_Epithelial_Cell	Metaplastic_Cell|Reactive_Epithelial_Cell	Metaplastic Epithelial Cell
C36817	Metaplastic_Squamous_Cell	Metaplastic_Epithelial_Cell	Metaplastic Squamous Cell
C36818	Large_Osteoclastic_Giant_Cell	Giant_Cell	Large Osteoclastic Giant Cell|Giant Cell, Large Osteoclastic
C36819	Neoplastic_Multinucleated_Giant_Cell	Giant_Cell|Neoplastic_Large_Cell	Neoplastic Multinucleated Giant Cell|Giant Cell, Neoplastic Multinucleated
C36820	Malignant_Neuroendocrine_Small_Cell	Malignant_Epithelial_Small_Cell|Malignant_Neuroendocrine_Cell	Malignant Neuroendocrine Small Cell
C36821	Malignant_Neuroendocrine_Large_Cell	Malignant_Epithelial_Large_Cell|Malignant_Neuroendocrine_Cell	Malignant Neuroendocrine Large Cell
C36822	Malignant_Epithelial_Large_Cell	Malignant_Epithelial_Cell|Neoplastic_Large_Cell	Malignant Epithelial Large Cell
C36823	Neoplastic_Spindle_Cell	Neoplastic_Cell	Neoplastic Spindle Cell
C36824	Malignant_Epithelial_Giant_Cell	Giant_Epithelial_Cell|Malignant_Epithelial_Large_Cell|Neoplastic_Multinucleated_Giant_Cell	Malignant Epithelial Giant Cell
C36825	Malignant_Neuroendocrine_Cell	Malignant_Endocrine_Cell|Neoplastic_Neuroendocrine_Cell	Malignant Neuroendocrine Cell
C36826	Bizarre_Neoplastic_Stromal_Giant_Cell	Neoplastic_Multinucleated_Stromal_Cell	Bizarre Neoplastic Stromal Giant Cell
C36827	Osteoclast-Like_Giant_Cell	Giant_Cell	Osteoclast-Like Giant Cell
C36828	Giant_Cell_with_Myoblastic_Differentiation	Neoplastic_Multinucleated_Giant_Cell|Neoplastic_Striated_Muscle_Cell	Giant Cell with Myoblastic Differentiation
C36829	Abnormal_Mesothelial_Cell	Abnormal_Cell	Abnormal Mesothelial Cell
C36830	Reactive_Mesothelial_Cell	Abnormal_Mesothelial_Cell	Reactive Mesothelial Cell
C36831	Malignant_Mesothelial_Cell	Malignant_Cell|Neoplastic_Mesothelial_Cell	Malignant Mesothelial Cell
C36832	Abnormal_Macrophage	Abnormal_Connective_and_Soft_Tissue_Cell	Abnormal Macrophage
C36833	Lipid-Laden_Macrophage	Abnormal_Macrophage	Lipid-Laden Macrophage
C36834	Tingible_Body_Macrophage	Abnormal_Macrophage	Tingible Body Macrophage|Tangible Body Macrophage
C36835	Neoplastic_Thyroid_Follicular_Cell	Neoplastic_Endocrine_Cell|Neoplastic_Glandular_Cell	Neoplastic Thyroid Gland Follicular Cell|Neoplastic Thyroid Follicular Cell
C36836	Malignant_Thyroid_Follicular_Cell	Adenocarcinoma_Cell|Malignant_Endocrine_Cell|Neoplastic_Thyroid_Follicular_Cell	Malignant Thyroid Gland Follicular Cell|Malignant Thyroid Follicular Cell
C36837	Metaplastic_Glandular_Cell	Metaplastic_Epithelial_Cell	Metaplastic Glandular Cell
C36838	High_Grade_Malignant_Transitional_Cell	Malignant_Transitional_Cell	High Grade Malignant Transitional Cell
C36839	Low_Grade_Malignant_Transitional_Cell	Malignant_Transitional_Cell	Low Grade Malignant Transitional Cell
C36840	Adenocarcinoma_Granular_Cell	Adenocarcinoma_Cell	Adenocarcinoma Granular Cell
C36841	Adenocarcinoma_Cell_with_Perinuclear_Clearing	Adenocarcinoma_Cell	Adenocarcinoma Cell with Perinuclear Clearing
C36842	Giant_Astrocyte	Neoplastic_Astrocyte|Neoplastic_Multinucleated_Giant_Cell	Giant Astrocyte
C36843	Abnormal_Connective_and_Soft_Tissue_Cell	Abnormal_Cell	Abnormal Connective and Soft Tissue Cell
C36844	Niemann-Pick_Cell	Abnormal_Macrophage	Niemann-Pick Cell
C36845	Xanthoma_Cell	Abnormal_Macrophage	Xanthoma Cell
C36846	Foamy_Macrophage	Abnormal_Macrophage	Foamy Macrophage
C36847	Hemosiderin-Laden_Macrophage	Abnormal_Macrophage	Hemosiderin-Laden Macrophage
C36848	Anaplastic_Carcinoma_Cell	Anaplastic_Cell|Malignant_Epithelial_Large_Cell	Anaplastic Carcinoma Cell|Anaplastic Malignant Epithelial Cell|Pleomorphic Carcinoma Cell|Pleomorphic Malignant Epithelial Cell
C36849	Neoplastic_Epithelial_Spindle_Cell	Neoplastic_Epithelial_Cell|Neoplastic_Spindle_Cell	Neoplastic Epithelial Spindle Cell
C36850	Polygonal_Adenocarcinoma_Cell_with_Eosinophilic_Cytoplasm	Adenocarcinoma_Cell|Neoplastic_Epithelial_Polygonal_Cell|Neoplastic_Polygonal_Cell_with_Eosinophilic_Cytoplasm	Polygonal Adenocarcinoma Cell with Eosinophilic Cytoplasm
C36851	Neoplastic_Polygonal_Cell	Neoplastic_Cell	Neoplastic Polygonal Cell
C36852	Neoplastic_Polygonal_Cell_with_Abundant_Granular_Cytoplasm	Neoplastic_Large_Cell|Neoplastic_Polygonal_Cell	Neoplastic Polygonal Cell with Abundant Granular Cytoplasm
C36853	Malignant_Neuroendocrine_Small_Cell_with_Round_Nucleus	Malignant_Neuroendocrine_Small_Cell	Malignant Neuroendocrine Small Cell with Round Nucleus
C36854	Malignant_Neuroendocrine_Spindle_Cell	Malignant_Neuroendocrine_Cell|Neoplastic_Neuroendocrine_Spindle_Cell	Malignant Neuroendocrine Spindle Cell
C36855	Malignant_Neuroendocrine_Polygonal_Cell	Malignant_Neuroendocrine_Cell|Neoplastic_Neuroendocrine_Polygonal_Cell	Malignant Neuroendocrine Polygonal Cell
C36856	Mucin-Producing_Adenocarcinoma_Cell	Adenocarcinoma_Cell|Mucin-Producing_Neoplastic_Epithelial_Cell	Mucin-Producing Adenocarcinoma Cell
C36857	Giant_Adenocarcinoma_Cell	Adenocarcinoma_Cell|Malignant_Epithelial_Giant_Cell	Giant Adenocarcinoma Cell
C36858	Ductal_Carcinoma_Cell	Adenocarcinoma_Cell|Neoplastic_Ductal_Epithelial_Cell	Ductal Carcinoma Cell
C36859	Acinar_Carcinoma_Cell	Adenocarcinoma_Cell|Neoplastic_Acinar_Cell	Acinar Carcinoma Cell
C36860	Malignant_Small_Cell	Malignant_Cell	Malignant Small Cell
C36861	Malignant_Small_Hyperchromatic_Cell	Malignant_Small_Cell	Malignant Small Hyperchromatic Cell
C36862	Neoplastic_Melanocyte	Neoplastic_Cell	Neoplastic Melanocyte
C36863	Balloon_Nevus_Cell	Nevus_Cell	Balloon Nevus Cell
C36864	Nevus_Cell_A-Type	Nevus_Cell	Nevus Cell A-Type
C36865	Nevus_Cell_B-Type	Nevus_Cell	Nevus Cell B-Type
C36866	Nevus_Cell_C-Type	Nevus_Cell	Nevus Cell C-Type
C36867	Atypical_Melanocyte	Neoplastic_Melanocyte	Atypical Melanocyte
C36868	Atypical_Spindle_Melanocyte	Atypical_Melanocyte|Spindle_Melanocyte	Atypical Spindle Melanocyte
C36869	Spindle_Melanocyte	Neoplastic_Melanocyte|Neoplastic_Spindle_Cell	Spindle Melanocyte
C36870	Epithelioid_Melanocyte	Neoplastic_Melanocyte	Epithelioid Melanocyte
C36871	Pagetoid_Cell	Neoplastic_Melanocyte	Pagetoid Cell
C36872	Epithelioid_Melanoma_Cell	Melanoma_Cell	Epithelioid Melanoma Cell
C36873	Melanoma_Cell	Malignant_Cell|Neoplastic_Melanocyte	Melanoma Cell
C36874	Spindle_Melanoma_Cell	Melanoma_Cell	Spindle Melanoma Cell
C36875	Metaplastic_Hurthle_Cell	Metaplastic_Glandular_Cell	Metaplastic Hurthle Cell
C36876	Adenocarcinoma_Cell_with_Intranuclear_Inclusion	Adenocarcinoma_Cell	Adenocarcinoma Cell with Intranuclear Inclusion
C36877	Neoplastic_Ductal_Epithelial_Cell	Neoplastic_Glandular_Cell	Neoplastic Ductal Epithelial Cell
C36878	Neoplastic_Lobular_Epithelial_Cell	Neoplastic_Glandular_Cell	Neoplastic Lobular Epithelial Cell
C36879	Lobular_Carcinoma_Cell	Adenocarcinoma_Cell|Neoplastic_Lobular_Epithelial_Cell	Lobular Carcinoma Cell
C36880	Adenocarcinoma_Cell_with_Eosinophilic_Granular_Cytoplasm	Adenocarcinoma_Cell|Neoplastic_Glandular_Cell_with_Eosinophilic_Granular_Cytoplasm	Adenocarcinoma Cell with Eosinophilic Granular Cytoplasm
C36881	Neoplastic_Glandular_Cell_with_Eosinophilic_Granular_Cytoplasm	Neoplastic_Cell_with_Eosinophilic_Cytoplasm|Neoplastic_Glandular_Cell	Neoplastic Glandular Cell with Eosinophilic Granular Cytoplasm
C36882	Metaplastic_Apocrine_Cell	Metaplastic_Glandular_Cell	Metaplastic Apocrine Cell
C36883	Atypical_Ductal_Epithelial_Cell	Atypical_Glandular_Cell	Atypical Ductal Epithelial Cell
C36884	Malignant_Polygonal_Cell_with_Abundant_Granular_Cytoplasm	Malignant_Cell|Neoplastic_Polygonal_Cell_with_Abundant_Granular_Cytoplasm	Malignant Polygonal Cell with Abundant Granular Cytoplasm
C36885	Atypical_Lobular_Epithelial_Cell	Atypical_Glandular_Cell	Atypical Lobular Epithelial Cell
C36886	Neoplastic_Plump_Epithelial_Cell	Neoplastic_Epithelial_Cell	Neoplastic Plump Epithelial Cell
C36887	Neoplastic_Connective_and_Soft_Tissue_Cell	Abnormal_Connective_and_Soft_Tissue_Cell|Neoplastic_Cell	Neoplastic Connective and Soft Tissue Cell
C36888	Neoplastic_Histiocyte	Neoplastic_Histiocytic_and_Dendritic_Cell	Neoplastic Histiocyte
C36889	Neoplastic_Langerhans_Cell	Neoplastic_Dendritic_Cell	Neoplastic Langerhans Cell
C36890	Malignant_Langerhans_Cell	Malignant_Cell|Neoplastic_Langerhans_Cell	Malignant Langerhans Cell
C36891	Mucin-Producing_Neoplastic_Epithelial_Cell	Neoplastic_Glandular_Cell	Mucin-Producing Neoplastic Epithelial Cell
C36892	Neoplastic_Interdigitating_Dendritic_Cell	Neoplastic_Dendritic_Cell	Neoplastic Interdigitating Dendritic Cell
C36893	Neoplastic_Follicular_Dendritic_Cell	Neoplastic_Dendritic_Cell	Neoplastic Follicular Dendritic Cell
C36894	Neoplastic_Granulosa_Cell	Neoplastic_Sex_Cord-Stromal_Cell	Neoplastic Granulosa Cell
C36895	Neoplastic_Sertoli_Cell	Neoplastic_Sex_Cord-Stromal_Cell	Neoplastic Sertoli Cell
C36896	Neoplastic_Leydig_Cell	Neoplastic_Sex_Cord-Stromal_Cell	Neoplastic Leydig Cell
C36897	Neoplastic_Primitive_Germ_Cell	Neoplastic_Germ_Cell	Neoplastic Primitive Germ Cell
C36898	Neoplastic_Sex_Cord-Stromal_Cell	Neoplastic_Cell	Neoplastic Sex Cord-Stromal Cell
C36899	Neoplastic_Stellate_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Neoplastic Stellate Cell
C36900	Neoplastic_Osteoblast	Neoplastic_Connective_and_Soft_Tissue_Cell	Neoplastic Osteoblast
C36901	Malignant_Osteoblast	Malignant_Connective_and_Soft_Tissue_Cell|Neoplastic_Osteoblast	Malignant Osteoblast
C36902	Signet_Ring_Stromal_Cell	Neoplastic_Sex_Cord-Stromal_Cell|Signet_Ring_Cell	Signet Ring Stromal Cell
C36903	Neoplastic_Germ_Cell	Neoplastic_Cell	Neoplastic Germ Cell
C36904	Neoplastic_Large_Germ_Cell	Neoplastic_Germ_Cell|Neoplastic_Large_Cell	Neoplastic Large Germ Cell
C36905	Neoplastic_Large_Pleomorphic_Germ_Cell	Neoplastic_Large_Germ_Cell	Neoplastic Large Pleomorphic Germ Cell
C36906	Neoplastic_Syncytiotrophoblastic_Cell	Abnormal_Syncytiotrophoblastic_Cell|Neoplastic_Trophoblastic_Cell	Neoplastic Syncytiotrophoblastic Cell
C36907	Primitive_Mesenchymal_Cell	Malignant_Connective_and_Soft_Tissue_Cell	Primitive Mesenchymal Cell
C36908	Apocrine_Ductal_Carcinoma_Cell	Ductal_Carcinoma_Cell	Apocrine Ductal Carcinoma Cell
C36909	Atypical_Metaplastic_Apocrine_Cell	Atypical_Glandular_Cell|Metaplastic_Apocrine_Cell	Atypical Metaplastic Apocrine Cell
C36910	Primitive_Mesenchymal_Round_Cell	Neoplastic_Round_Cell|Primitive_Mesenchymal_Cell	Primitive Mesenchymal Round Cell
C36911	Atypical_Transitional_Cell	Abnormal_Transitional_Cell|Atypical_Epithelial_Cell	Atypical Transitional Cell
C36912	Atypical_Glandular_Cell	Abnormal_Glandular_Cell|Atypical_Epithelial_Cell	Atypical Glandular Cell
C36913	Atypical_Squamous_Cell	Abnormal_Squamous_Cell|Atypical_Epithelial_Cell	Atypical Squamous Cell
C36914	Atypical_Epithelial_Cell	Abnormal_Epithelial_Cell	Atypical Epithelial Cell
C36915	Reactive_Transitional_Cell	Abnormal_Transitional_Cell|Reactive_Epithelial_Cell	Reactive Transitional Cell
C36916	Malignant_Neuroendocrine_Cell_with_Moderate_Cytoplasm	Malignant_Neuroendocrine_Cell	Malignant Neuroendocrine Cell with Moderate Cytoplasm
C36917	Malignant_Neuroendocrine_Cell_with_Abundant_Cytoplasm	Malignant_Neuroendocrine_Cell	Malignant Neuroendocrine Cell with Abundant Cytoplasm
C36918	Neoplastic_Prolactin_Cell	Neoplastic_Adenohypophysial_Cell	Neoplastic Lactotroph Cell|Neoplastic Prolactin Cell
C36919	Neoplastic_Growth_Hormone_Cell	Neoplastic_Adenohypophysial_Cell	Neoplastic Somatotroph Cell|Neoplastic Growth Hormone Cell
C36920	Neoplastic_Corticotroph_Cell	Neoplastic_Adenohypophysial_Cell	Neoplastic Corticotroph Cell
C36921	Neoplastic_Gonadotroph_Cell	Neoplastic_Adenohypophysial_Cell	Neoplastic Gonadotroph Cell
C36922	Neoplastic_Thyrotroph_Cell	Neoplastic_Adenohypophysial_Cell	Neoplastic Thyrotroph Cell
C36923	Neoplastic_Endocrine_Null_Cell	Neoplastic_Adenohypophysial_Cell	Neoplastic Endocrine Null Cell
C36924	Neoplastic_Acidophilic_Stem_Cell	Neoplastic_Adenohypophysial_Cell	Neoplastic Acidophilic Stem Cell
C36925	Neoplastic_Endocrine_Cell	Neoplastic_Epithelial_Cell	Neoplastic Endocrine Cell
C36926	Neoplastic_Fasciculata_Cell	Neoplastic_Adrenal_Cortical_Cell	Neoplastic Fasciculata Cell
C36927	Neoplastic_Glomerulosa_Cell	Neoplastic_Adrenal_Cortical_Cell	Neoplastic Glomerulosa Cell
C36928	Primitive_Mesenchymal_Stellate_Cell	Primitive_Mesenchymal_Cell	Primitive Mesenchymal Stellate Cell
C36929	Malignant_Endocrine_Cell	Malignant_Epithelial_Cell|Neoplastic_Endocrine_Cell	Malignant Endocrine Cell
C36930	Neoplastic_Endocrine_Clear_Cell	Neoplastic_Endocrine_Cell|Neoplastic_Epithelial_Clear_Cell	Neoplastic Endocrine Clear Cell
C36931	Neoplastic_Endocrine_Compact_Cell	Neoplastic_Adrenal_Cortical_Cell	Neoplastic Adrenal Cortical Compact Cell|Neoplastic Adrenal Compact Cell|Neoplastic Endocrine Compact Cell
C36932	Polygonal_or_Elongated_Mononuclear_Mesenchymal_Cell	Primitive_Mesenchymal_Cell	Polygonal or Elongated Mononuclear Mesenchymal Cell
C36933	Neoplastic_Neuroendocrine_Polygonal_Cell	Neoplastic_Epithelial_Polygonal_Cell|Neoplastic_Neuroendocrine_Cell	Neoplastic Neuroendocrine Polygonal Cell
C36934	Neoplastic_Neuroendocrine_Polygonal_Cell_with_Cytoplasmic_Eosinophilic_Globules	Neoplastic_Neuroendocrine_Polygonal_Cell	Neoplastic Neuroendocrine Polygonal Cell with Cytoplasmic Eosinophilic Globules
C36935	Neoplastic_Neuroendocrine_Spindle_Cell	Neoplastic_Epithelial_Spindle_Cell|Neoplastic_Neuroendocrine_Cell	Neoplastic Neuroendocrine Spindle Cell
C36936	Neoplastic_Muscle_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Neoplastic Muscle Cell
C36937	Neoplastic_Smooth_Muscle_Cell	Neoplastic_Muscle_Cell	Neoplastic Smooth Muscle Cell
C36938	Neoplastic_Endocrine_Chief_Cell	Neoplastic_Endocrine_Cell	Neoplastic Endocrine Chief Cell
C36939	Neoplastic_Clear_Cell_Oncocyte	Neoplastic_Epithelial_Clear_Cell|Neoplastic_Oncocyte	Neoplastic Clear Cell Oncocyte
C36940	Malignant_Clear_Cell_Oncocyte	Malignant_Epithelial_Clear_Cell|Malignant_Oncocyte|Neoplastic_Clear_Cell_Oncocyte	Malignant Clear Cell Oncocyte
C36941	Neoplastic_Oncocyte	Neoplastic_Glandular_Cell	Neoplastic Oncocyte
C36942	Malignant_Oncocyte	Adenocarcinoma_Cell|Neoplastic_Oncocyte	Malignant Oncocyte
C36943	Neoplastic_Acinar_Cell	Neoplastic_Glandular_Cell	Neoplastic Acinar Cell
C36944	Malignant_Small_Undifferentiated_Cell	Malignant_Small_Cell	Malignant Small Undifferentiated Cell
C36945	Spindle_Shaped_Smooth_Muscle_Cell	Neoplastic_Connective_and_Soft_Tissue_Spindle_Cell|Neoplastic_Smooth_Muscle_Cell	Neoplastic Spindle Shaped Smooth Muscle Cell
C36946	Pleomorphic_Smooth_Muscle_Cell	Neoplastic_Smooth_Muscle_Cell	Pleomorphic Smooth Muscle Cell
C36947	Neoplastic_Striated_Muscle_Cell	Neoplastic_Muscle_Cell	Neoplastic Striated Muscle Cell
C36948	Strap-Like_Striated_Muscle_Cell	Neoplastic_Striated_Muscle_Cell	Strap-Like Striated Muscle Cell
C36949	Primitive_Striated_Muscle_Cell	Neoplastic_Striated_Muscle_Cell	Primitive Striated Muscle Cell
C36950	Round_Striated_Muscle_Cell	Neoplastic_Striated_Muscle_Cell	Round Striated Muscle Cell
C36951	Round_Cell_with_Primitive_Myoblastic_Differentiation	Neoplastic_Round_Cell|Neoplastic_Striated_Muscle_Cell	Round Cell with Primitive Myoblastic Differentiation
C36952	Spindle_Cell_Myoblast	Neoplastic_Connective_and_Soft_Tissue_Spindle_Cell|Neoplastic_Striated_Muscle_Cell	Spindle Cell Myoblast
C36953	Bizarre_Cell_with_Evidence_of_Skeletal_Muscle_Differentiation	Neoplastic_Striated_Muscle_Cell	Bizarre Cell with Evidence of Skeletal Muscle Differentiation
C36954	Neoplastic_Connective_and_Soft_Tissue_Spindle_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell|Neoplastic_Spindle_Cell	Neoplastic Connective and Soft Tissue Spindle Cell
C36955	Spindle-Shaped_Fibroblast	Neoplastic_Fibroblast	Neoplastic Spindle-Shaped Fibroblast
C36956	Atypical_Fibroblastic_Spindle_Cell	Neoplastic_Fibroblast	Atypical Fibroblastic Spindle Cell
C36957	Spindle-Shaped_Myofibroblast	Neoplastic_Connective_and_Soft_Tissue_Spindle_Cell	Neoplastic Spindle-Shaped Myofibroblast
C36958	Immature_Spindle_Cell	Neoplastic_Connective_and_Soft_Tissue_Spindle_Cell	Immature Spindle Cell
C36959	Neoplastic_Fibroblast-Like_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Neoplastic Fibroblast-Like Cell
C36960	Neoplastic_Histiocytic_Cell	Retired_Concepts	Neoplastic Histiocytic Cell
C36961	Neoplastic_Histiocyte-Like_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Neoplastic Histiocyte-Like Cell
C36962	Neoplastic_Fibrohistiocytic_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Neoplastic Fibrohistiocytic Cell
C36963	Neoplastic_Fusiform_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Neoplastic Fusiform Cell
C36964	Neoplastic_Myoid_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Neoplastic Myoid Cell
C36965	Glomus_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Glomus Cell
C36966	Atypical_Glomus_Cell	Glomus_Cell	Atypical Glomus Cell
C36967	Polygonal_Brown_Fat_Cell	Neoplastic_Lipocyte|Neoplastic_Polygonal_Cell	Polygonal Brown Fat Cell
C36968	Multivacuolated_Brown_Fat_Cell	Polygonal_Brown_Fat_Cell	Multivacuolated Brown Fat Cell
C36969	Eosinophilic_Brown_Fat_Cell	Polygonal_Brown_Fat_Cell	Eosinophilic Brown Fat Cell|Granular Brown Fat Cell
C36970	Pale_Brown_Fat_Cell	Polygonal_Brown_Fat_Cell	Pale Brown Fat Cell
C36971	Multilobated_Lipoblast-Like_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Multilobated Lipoblast-Like Cell
C36972	Monovacuolated_Lipoblast	Neoplastic_Lipocyte	Monovacuolated Lipoblast
C36973	Multivacuolated_Lipoblast	Neoplastic_Lipocyte	Multivacuolated Lipoblast
C36974	Pleomorphic_Lipoblast	Neoplastic_Lipocyte|Pleomorphic_Connective_and_Soft_Tissue_Cell	Pleomorphic Lipoblast
C36975	Signet-Ring_Lipoblast	Neoplastic_Lipocyte	Signet Ring Lipoblast
C36976	Mature-Appearing_Adipocyte	Neoplastic_Lipocyte	Mature-Appearing Adipocyte
C36977	Atypical_Adipocyte	Neoplastic_Lipocyte	Atypical Adipocyte
C36978	Adipocyte_with_Nuclear_Atypia	Atypical_Adipocyte	Adipocyte with Nuclear Atypia
C36979	Hyperchromatic_Adipocyte	Atypical_Adipocyte	Hyperchromatic Adipocyte
C36980	Hyperchromatic_Stromal_Cell	Neoplastic_Stromal_Cell	Hyperchromatic Stromal Cell
C36981	Ganglion-Like_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Ganglion-Like Cell
C36982	Chondrocyte-Like_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Chondrocyte-like Cell
C36983	Neoplastic_Chondrocyte	Neoplastic_Cartilage_Cell	Neoplastic Chondrocyte
C36984	Atypical_Chondrocyte	Neoplastic_Chondrocyte	Atypical Chondrocyte
C36985	Neoplastic_Chondroblast	Neoplastic_Cartilage_Cell	Neoplastic Chondroblast
C36986	Neoplastic_Chondroblast-Like_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Neoplastic Chondroblast-Like Cell
C36987	Abnormal_Hematopoietic_Cell	Abnormal_Cell	Abnormal Hematopoietic and Lymphoid Cell
C36988	Neoplastic_Lymphocyte	Abnormal_Lymphocyte|Malignant_Cell|Neoplastic_Hematopoietic_Cell	Neoplastic Lymphocyte
C36989	Paraimmunoblast	Neoplastic_B-Lymphocyte	Paraimmunoblast
C36990	Neoplastic_Small_to_Medium-Sized_Lymphocyte	Neoplastic_Lymphocyte	Neoplastic Small to Medium-Sized Lymphocyte
C36991	Small_to_Medium-Sized_Lymphocyte_with_Pale_Cytoplasm	Neoplastic_B-Lymphocyte|Neoplastic_Small_to_Medium-Sized_Lymphocyte	Neoplastic Small to Medium-Sized B-Lymphocyte with Pale Cytoplasm
C36992	Neoplastic_Medium-Sized_to_Large_Lymphocyte	Neoplastic_Lymphocyte	Neoplastic Medium-Sized to Large Lymphocyte
C36993	Lymphocyte_with_Basophilic_Villous_Cytoplasm	Hairy_Cell	Lymphocyte with Basophilic Villous Cytoplasm
C36994	Neoplastic_Natural_Killer-Cell	Neoplastic_T-Lymphocyte_and_Neoplastic_Natural_Killer_Cell	Neoplastic Natural Killer Cell|Neoplastic NK-Cell
C36995	Pleomorphic_Lymphocyte	Neoplastic_Lymphocyte|Pleomorphic_Cell	Pleomorphic Lymphocyte
C36996	Pleomorphic_B-Cell	Neoplastic_B-Lymphocyte|Pleomorphic_Lymphocyte	Pleomorphic B-Lymphocyte
C36997	Pleomorphic_T-Cell	Neoplastic_T-Lymphocyte|Pleomorphic_Lymphocyte	Pleomorphic T-Lymphocyte
C36998	Neoplastic_Small_Lymphocyte	Neoplastic_Lymphocyte	Neoplastic Small Lymphocyte
C36999	Small_Lymphocyte_with_Clumped_Chromatin	Neoplastic_Small_B-Lymphocyte	Neoplastic Small Lymphocyte with Clumped Chromatin
C37000	Lymphoplasmacytoid_Cell	Neoplastic_B-Lymphocyte	Lymphoplasmacytoid Cell|Plasmacytoid Lymphocyte
C37001	Centrocyte-Like_Cell	Neoplastic_B-Lymphocyte	Centrocyte-Like Cell
C37002	Neoplastic_Small_Cleaved_Cell	Centrocyte|Neoplastic_Small_B-Lymphocyte	Neoplastic Small Cleaved Follicle Center Cell|Neoplastic Small Centrocyte
C37003	Neoplastic_Monocytoid_B-Cell	Neoplastic_B-Lymphocyte	Neoplastic Monocytoid B-Lymphocyte
C37004	Neoplastic_Medium-Sized_Lymphocyte	Neoplastic_Lymphocyte	Neoplastic Medium-Sized Lymphocyte
C37005	Medium-Sized_Lymphocyte_with_Basophilic_Cytoplasm	Neoplastic_B-Lymphocyte|Neoplastic_Medium-Sized_Lymphocyte	Neoplastic Medium-Sized B-Lymphocyte with Basophilic Cytoplasm
C37006	Medium-Sized_Lymphocyte_with_Eccentric_Basophilic_Cytoplasm	Medium-Sized_Lymphocyte_with_Basophilic_Cytoplasm	Neoplastic Medium-Sized B-Lymphocyte with Eccentric Basophilic Cytoplasm
C37007	Medium-Sized_Lymphocyte_with_Pale_Cytoplasm	Neoplastic_Medium-Sized_Lymphocyte	Neoplastic Medium-Sized Lymphocyte with Pale Cytoplasm
C37008	Neoplastic_Large_Lymphocyte	Neoplastic_Large_Cell|Neoplastic_Lymphocyte	Neoplastic Large Lymphocyte
C37009	Neoplastic_Immunoblast	Neoplastic_Large_Lymphocyte	Neoplastic Immunoblast
C37010	Neoplastic_B-Immunoblast	Neoplastic_Immunoblast|Neoplastic_Large_B-Lymphocyte	Neoplastic B-Immunoblast
C37011	Plasmablastic_Immunoblast	Neoplastic_B-Immunoblast	Plasmablastic Immunoblast
C37012	Neoplastic_T-Immunoblast	Neoplastic_Immunoblast|Neoplastic_Large_T-Lymphocyte	Neoplastic T-Immunoblast
C37013	Neoplastic_Large_B-Lymphocyte	Neoplastic_B-Lymphocyte|Neoplastic_Large_Lymphocyte	Neoplastic Large B-Lymphocyte
C37014	Neoplastic_Large_Non-Cleaved_Cell	Neoplastic_Follicle_Center_Cell|Neoplastic_Large_B-Lymphocyte	Neoplastic Centroblast|Neoplastic Large Non-Cleaved Follicle Center Cell
C37015	Anaplastic_Large_B-Cell	Anaplastic_Large_Lymphocyte|Neoplastic_Large_B-Lymphocyte	Anaplastic Large B-Lymphocyte
C37016	Neoplastic_Large_T-Lymphocyte	Neoplastic_Large_Lymphocyte|Neoplastic_T-Lymphocyte	Neoplastic Large T-Lymphocyte
C37017	Anaplastic_Large_T-Cell	Anaplastic_Large_Lymphocyte|Anaplastic_T-Cell|Neoplastic_Large_T-Lymphocyte	Anaplastic Large T-Lymphocyte
C37018	Anaplastic_Large_Lymphocyte	Anaplastic_Cell|Neoplastic_Large_Lymphocyte	Anaplastic Large Lymphocyte
C37019	Neoplastic_Large_Granular_Lymphocyte	Abnormal_Large_Granular_Lymphocyte|Leukemic_Lymphocyte|Neoplastic_Large_T-Lymphocyte	Neoplastic T-Cell Large Granular Lymphocyte
C37020	Neoplastic_Large_Cleaved_Cell	Centrocyte|Neoplastic_Large_B-Lymphocyte	Neoplastic Large Cleaved Follicle Center Cell|Neoplastic Large Centrocyte
C37021	Hodgkin_s_Cell	Reed-Sternberg_Cell	Hodgkin's Cell|Mononuclear Reed-Sternberg Cell Variant
C37022	Binucleated_Reed-Sternberg_Cell	Classical_Reed-Sternberg_Cell	Binucleated Reed-Sternberg Cell
C37023	Lacunar_Reed-Sternberg_Cell	Reed-Sternberg_Cell	Lacunar Reed-Sternberg Cell
C37024	Reed-Sternberg-Like_Cell	Neoplastic_Large_Lymphocyte	Reed-Sternberg-Like Cell|R-S-Like Cell
C37025	Mummified_Cell	Reed-Sternberg_Cell	Mummified Cell
C37026	Hodgkin_s-Like_Cell	Neoplastic_Large_Lymphocyte	Hodgkin's-Like Cell
C37027	Lymphocytic_and_Histiocytic_Cell	Reed-Sternberg_Cell	Lymphocytic and Histiocytic Cell|L&H Cell|Lymphocytic and Histiocytic Reed-Sternberg Cell Variant|Popcorn Cell
C37028	Lymphocyte_with_Abundant_Pale_Cytoplasm	Neoplastic_Large_Lymphocyte	Lymphocyte with Abundant Pale Cytoplasm
C37029	Abnormal_Neutrophil	Abnormal_Hematopoietic_Cell	Abnormal Neutrophil
C37030	Toxic_Neutrophil	Abnormal_Neutrophil	Toxic Neutrophil
C37031	Dysplastic_Neutrophil	Abnormal_Neutrophil	Dysplastic Neutrophil
C37032	Abnormal_Eosinophil	Abnormal_Hematopoietic_Cell	Abnormal Eosinophil
C37033	Hypochromic_Red_Blood_Cell	Abnormal_Red_Blood_Cell	Hypochromic Red Blood Cell
C37034	Microcytic_Red_Blood_Cell	Abnormal_Red_Blood_Cell	Microcytic Red Blood Cell
C37036	Neoplastic_Epithelial_Polygonal_Cell	Neoplastic_Epithelial_Cell|Neoplastic_Polygonal_Cell	Neoplastic Epithelial Polygonal Cell
C37037	Malignant_Basaloid_Squamous_Cell	Malignant_Squamous_Cell	Malignant Basaloid Squamous Cell
C37038	Abnormal_Platelet	Abnormal_Hematopoietic_Cell	Abnormal Platelet|Atypical Platelet
C37039	Large_Atypical_Platelet	Abnormal_Platelet	Large Atypical Platelet
C37040	Abnormal_Monocyte	Abnormal_Myeloid_Cell	Abnormal Monocyte
C37041	Neoplastic_Monocyte	Abnormal_Monocyte|Neoplastic_Myeloid_Cell	Neoplastic Monocyte
C37042	Abnormal_Myeloid_Cell	Abnormal_Hematopoietic_Cell	Abnormal Myeloid Cell
C37043	Abnormal_Megakaryocyte	Abnormal_Myeloid_Cell	Abnormal Megakaryocyte
C37044	Large_Megakaryocyte	Abnormal_Megakaryocyte	Large Megakaryocyte
C37045	Giant_Megakaryocyte	Abnormal_Megakaryocyte	Giant Megakaryocyte
C37046	Dysplastic_Megakaryocyte	Abnormal_Megakaryocyte	Dysplastic Megakaryocyte
C37047	Hypolobated_Megakaryocyte	Dysplastic_Megakaryocyte	Hypolobated Megakaryocyte
C37048	Monolobed_Megakaryocyte	Hypolobated_Megakaryocyte	Monolobed Megakaryocyte
C37049	Hyperchromatic_Megakaryocyte	Dysplastic_Megakaryocyte	Hyperchromatic Megakaryocyte
C37050	Abnormal_Granulocyte	Abnormal_Myeloid_Cell	Abnormal Granulocyte
C37051	Dysplastic_Granulocyte	Abnormal_Granulocyte	Dysplastic Granulocyte
C37052	Faggot_Cell	Neoplastic_Granulocyte	Faggot Cell
C37053	Abnormal_Erythroid_Precursor	Abnormal_Myeloid_Cell	Abnormal Erythroid Precursor
C37054	Dysplastic_Erythroid_Precursor	Abnormal_Erythroid_Precursor	Dysplastic Erythroid Precursor
C37055	Large_Multinucleated_Erythroid_Cell	Dysplastic_Erythroid_Precursor	Large Multinucleated Erythroid Cell
C37056	Dysplastic_Erythroblast	Abnormal_Erythroblast|Dysplastic_Erythroid_Precursor	Dysplastic Erythroblast
C37057	Abnormal_Erythroblast	Abnormal_Erythroid_Precursor	Abnormal Erythroblast
C37058	Ringed_Sideroblast	Sideroblast	Ringed Sideroblast
C37059	Large_Erythroblast	Neoplastic_Erythroblast	Neoplastic Large Erythroblast
C37060	Neoplastic_Hematopoietic_Cell	Abnormal_Hematopoietic_Cell|Neoplastic_Cell	Neoplastic Hematopoietic and Lymphoid Cell
C37061	Clonal_Hematopoietic_Stem_Cell	Malignant_Cell|Neoplastic_Hematopoietic_Cell	Clonal Hematopoietic Stem Cell
C37062	Neoplastic_Mast_Cell	Neoplastic_Hematopoietic_Cell	Neoplastic Mast Cell
C37063	Immature_Mast_Cell	Malignant_Cell|Neoplastic_Mast_Cell	Immature Mast Cell
C37064	Neoplastic_Blast	Leukemic_Cell	Neoplastic Blast
C37065	Neoplastic_Myeloblast	Neoplastic_Granulocyte|Neoplastic_Myeloid_Blast	Neoplastic Myeloblast
C37066	Neoplastic_Blast_with_Basophilic_Cytoplasm	Neoplastic_Myeloblast	Neoplastic Myeloblast with Basophilic Cytoplasm
C37067	Neoplastic_Myeloid_Blast	Neoplastic_Blast|Neoplastic_Myeloid_Cell	Neoplastic Myeloid Blast
C37068	Neoplastic_Megakaryoblast	Neoplastic_Myeloid_Blast	Neoplastic Megakaryoblast
C37070	Neoplastic_B-Lymphoblast	Atypical_Lymphoblast|Neoplastic_B-Lymphocyte	Neoplastic B-Lymphoblast
C37071	Neoplastic_T-Lymphoblast	Atypical_Lymphoblast|Neoplastic_T-Lymphocyte	Neoplastic T-Lymphoblast
C37072	Neoplastic_Promyelocyte	Neoplastic_Granulocyte	Neoplastic Promyelocyte
C37073	Hypergranular_Promyelocyte	Neoplastic_Promyelocyte	Hypergranular Promyelocyte
C37074	Hypogranular_Promyelocyte	Neoplastic_Promyelocyte	Hypogranular Promyelocyte
C37075	Neoplastic_Promonocyte	Neoplastic_Myeloid_Cell	Neoplastic Promonocyte
C37076	Neoplastic_Neutrophilic_Precursor	Neoplastic_Granulocyte	Neoplastic Neutrophilic Precursor
C37077	Neoplastic_Plasma_Cell	Neoplastic_B-Lymphocyte	Neoplastic Plasma Cell
C37078	Pseudo-Gaucher_Cell	Neoplastic_Plasma_Cell	Pseudo-Gaucher Cell|Thesaurocyte
C37079	Mott_Cell	Neoplastic_Plasma_Cell	Mott Cell
C37080	Flame_Cell	Neoplastic_Plasma_Cell	Flame Cell
C37081	Anaplastic_Plasma_Cell	Neoplastic_Plasma_Cell	Anaplastic Plasma Cell
C37082	Plasmablast	Neoplastic_Plasma_Cell	Plasmablast
C37083	Pleomorphic_Plasma_Cell	Neoplastic_Plasma_Cell	Pleomorphic Plasma Cell
C37084	Hyperchromatic_Spindle_Cell	Neoplastic_Spindle_Cell	Hyperchromatic Spindle Cell
C37085	Undifferentiated_Carcinoma_Cell	Malignant_Epithelial_Cell	Undifferentiated Carcinoma Cell
C37086	Abnormal_Endothelial_Cell	Abnormal_Connective_and_Soft_Tissue_Cell	Abnormal Endothelial Cell
C37087	Atypical_Endothelial_Cell	Abnormal_Endothelial_Cell	Atypical Endothelial Cell
C37088	Neoplastic_Endothelial_Cell	Abnormal_Endothelial_Cell|Neoplastic_Connective_and_Soft_Tissue_Cell	Neoplastic Endothelial Cell
C37089	Hyperchromatic_Endothelial_Cell	Neoplastic_Endothelial_Cell	Hyperchromatic Endothelial Cell
C37090	Primitive_Mesenchymal_Plump_Cell	Primitive_Mesenchymal_Cell	Primitive Mesenchymal Plump Cell
C37091	Vacuolated_Endothelial_Cell	Neoplastic_Endothelial_Cell	Vacuolated Endothelial Cell
C37092	Spindle_Endothelial_Cell	Neoplastic_Endothelial_Cell	Spindle Endothelial Cell
C37093	Epithelioid_Endothelial_Cell	Neoplastic_Endothelial_Cell	Epithelioid Endothelial Cell|Histiocytoid Endothelial Cell
C37094	Large_Round_Epithelioid_Endothelial_Cell	Epithelioid_Endothelial_Cell	Large Round Epithelioid Endothelial Cell
C37095	Neoplastic_Hurthle_Cell	Neoplastic_Oncocyte|Neoplastic_Thyroid_Follicular_Cell	Neoplastic Thyroid Gland Oncocyte|Neoplastic Hurthle Cell|Neoplastic Thyroid Gland Oxyphil Cell
C37096	Metaplastic_Columnar_Cell	Metaplastic_Glandular_Cell	Metaplastic Columnar Cell
C37097	Malignant_Hurthle_Cell	Malignant_Oncocyte|Malignant_Thyroid_Follicular_Cell|Neoplastic_Hurthle_Cell	Malignant Thyroid Gland Oncocyte|Malignant Hurthle Cell|Malignant Thyroid Gland Oxyphil Cell
C37098	Neoplastic_Merkel_Cell	Malignant_Neuroendocrine_Cell	Neoplastic Merkel Cell
C37099	Neoplastic_Round_Cell	Neoplastic_Cell	Neoplastic Round Cell
C37100	Neoplastic_Small_Round_Cell	Neoplastic_Round_Cell	Neoplastic Small Round Cell
C37101	Neoplastic_Round_Cell_with_Neuronal_Differentiation	Neoplastic_Round_Cell	Neoplastic Round Cell with Neuronal Differentiation
C37102	Neoplastic_Round_Cell_with_Lipomatous_Differentiation	Neoplastic_Round_Cell	Neoplastic Round Cell with Lipomatous Differentiation
C37103	Neoplastic_Small_Cell	Neoplastic_Cell	Neoplastic Small Cell
C37104	Neoplastic_Epithelioid_Cell	Neoplastic_Cell	Neoplastic Epithelioid Cell
C37105	Neoplastic_Cell_with_Eosinophilic_Cytoplasm	Neoplastic_Cell	Neoplastic Cell with Eosinophilic Cytoplasm
C37106	Neoplastic_Large_Cell_with_Abundant_Eosinophilic_Cytoplasm	Neoplastic_Cell_with_Eosinophilic_Cytoplasm|Neoplastic_Large_Cell_with_Abundant_Cytoplasm	Neoplastic Large Cell with Abundant Eosinophilic Cytoplasm
C37107	Neoplastic_Large_Cell_with_Abundant_Cytoplasm	Neoplastic_Large_Cell	Neoplastic Large Cell with Abundant Cytoplasm
C37108	Adenocarcinoma_Spindle_Cell	Adenocarcinoma_Cell|Malignant_Epithelial_Spindle_Cell	Adenocarcinoma Spindle Cell
C37109	Malignant_Epithelial_Spindle_Cell	Malignant_Epithelial_Cell|Neoplastic_Epithelial_Spindle_Cell	Malignant Epithelial Spindle Cell
C37110	Anaplastic_Melanocyte	Neoplastic_Melanocyte	Anaplastic Melanocyte
C37111	Pleomorphic_Cell	Neoplastic_Cell	Pleomorphic Cell
C37112	Pleomorphic_Connective_and_Soft_Tissue_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell|Pleomorphic_Cell	Pleomorphic Connective and Soft Tissue Cell
C37113	Neoplastic_Fetal_Epithelial_Cell	Neoplastic_Epithelial_Cell	Neoplastic Fetal Epithelial Cell
C37114	Neoplastic_Serous_Epithelial_Cell	Neoplastic_Glandular_Cell	Neoplastic Serous Epithelial Cell
C37115	Serous_Adenocarcinoma_Cell	Adenocarcinoma_Cell|Neoplastic_Serous_Epithelial_Cell	Serous Adenocarcinoma Cell
C37116	Neoplastic_Mucinous_Epithelial_Cell	Neoplastic_Glandular_Cell	Neoplastic Mucinous Epithelial Cell
C37117	Mucinous_Adenocarcinoma_Cell	Adenocarcinoma_Cell|Neoplastic_Mucinous_Epithelial_Cell	Mucinous Adenocarcinoma Cell
C37118	Atypical_Epithelioid_Cell	Neoplastic_Epithelioid_Cell	Atypical Epithelioid Cell
C37119	Immature_Myxoid_Mesenchymal_Cell	Primitive_Mesenchymal_Cell	Immature Myxoid Mesenchymal Cell
C37120	Immature_Spindle_Mesenchymal_Cell	Immature_Spindle_Cell|Primitive_Mesenchymal_Cell	Immature Spindle Mesenchymal Cell
C37121	Neoplastic_Blastemal_Cell	Neoplastic_Cell	Neoplastic Blastemal Cell
C37122	Neoplastic_Glandular_Cell_with_Enlarged_Nucleus	Dysplastic_Glandular_Cell	Neoplastic Glandular Cell with Enlarged Nucleus
C37123	Neoplastic_Spindle-Shaped_to_Round_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Neoplastic Spindle-Shaped to Round Cell
C37124	Neoplastic_Multinucleated_Stromal_Cell	Neoplastic_Stromal_Cell	Neoplastic Multinucleated Stromal Cell
C37125	Neoplastic_Neuroepithelial_Cell	Neoplastic_Neuroepithelial_Cell_and_Neoplastic_Perineural_Cell	Neoplastic Neuroepithelial Cell
C37126	Neoplastic_Glial_Cell	Neoplastic_Neuroepithelial_Cell	Neoplastic Glial Cell
C37127	Neoplastic_Astrocyte	Neoplastic_Glial_Cell	Neoplastic Astrocyte
C37128	Neoplastic_Glandular_Cell_with_Enlarged_Nucleus_and_Prominent_Nucleolus	Neoplastic_Glandular_Cell_with_Enlarged_Nucleus	Neoplastic Glandular Cell with Enlarged Nucleus and Prominent Nucleolus
C37129	Fibrillary_Neoplastic_Astrocyte	Neoplastic_Astrocyte	Fibrillary Neoplastic Astrocyte
C37130	Neoplastic_Germ_Cell_with_Clear_to_Lightly_Eosinophilic_Cytoplasm	Neoplastic_Germ_Cell	Neoplastic Germ Cell with Clear to Lightly Eosinophilic Cytoplasm
C37131	Small_Lymphocyte-Like_Neoplastic_Germ_Cell	Neoplastic_Germ_Cell	Small Lymphocyte-Like Neoplastic Germ Cell
C37132	Gemistocytic_Neoplastic_Astrocyte	Neoplastic_Astrocyte	Gemistocytic Neoplastic Astrocyte
C37133	Intermediate-Sized_Neoplastic_Germ_Cell	Neoplastic_Germ_Cell	Intermediate-Sized Neoplastic Germ Cell
C37134	Giant_Neoplastic_Germ_Cell	Neoplastic_Large_Germ_Cell|Neoplastic_Multinucleated_Giant_Cell	Giant Neoplastic Germ Cell
C37135	Neoplastic_Astrocyte_with_Few_Flaccid_Processes	Neoplastic_Astrocyte	Neoplastic Astrocyte with Few Flaccid Processes
C37136	Anaplastic_Astrocyte	Neoplastic_Astrocyte	Anaplastic Astrocyte
C37137	Poorly_Differentiated_Neoplastic_Astrocyte	Neoplastic_Astrocyte	Poorly Differentiated Neoplastic Astrocyte
C37138	Bipolar_Cell_with_Rosenthal_Fiber	Neoplastic_Astrocyte	Neoplastic Piloid Astrocyte|Neoplastic Bipolar Astrocyte
C37139	Xanthomatous_Astrocyte	Neoplastic_Astrocyte	Xanthomatous Astrocyte
C37140	Neoplastic_Cytotrophoblastic_Cell	Abnormal_Cytotrophoblastic_Cell|Neoplastic_Trophoblastic_Cell	Neoplastic Cytotrophoblastic Cell
C37141	Neoplastic_Oligodendroglia_Cell	Neoplastic_Glial_Cell	Neoplastic Oligodendrocyte|Neoplastic Oligodendroglia Cell
C37142	Neoplastic_Intermediate_Type_Trophoblastic_Cell	Abnormal_Intermediate_Type_Trophoblastic_Cell|Neoplastic_Trophoblastic_Cell	Neoplastic Intermediate Type Trophoblastic Cell
C37143	Neoplastic_Ependymal_Cell	Neoplastic_Glial_Cell	Neoplastic Ependymal Cell
C37144	Neoplastic_Elongated_Glial_Cell	Neoplastic_Glial_Cell	Neoplastic Elongated Glial Cell
C37145	Neuroblastic_Cell	Neoplastic_Neuroepithelial_Cell	Neoplastic Neuroblast
C37146	Neoplastic_Ganglion_Cell	Neoplastic_Neuroepithelial_Cell	Neoplastic Ganglion Cell
C37147	Neoplastic_Oligodendroglia-Like_Cell	Neoplastic_Glial_Cell	Neoplastic Oligodendrocyte-Like Cell
C37148	Neoplastic_Neural_Crest_Cell	Neoplastic_Cell	Neoplastic Neural Crest Cell
C37149	Rhabdoid_Cell	Neoplastic_Cell	Rhabdoid Cell
C37150	Neoplastic_Stromal_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Neoplastic Stromal Cell
C37151	Neoplastic_Schwann_Cell	Neoplastic_Perineural_Cell	Neoplastic Schwann Cell
C37152	Perineurial-Like_Cell	Neoplastic_Perineural_Cell	Neoplastic Perineurial-Like Cell
C37153	Malignant_Stromal_Cell	Malignant_Connective_and_Soft_Tissue_Cell|Neoplastic_Stromal_Cell	Malignant Stromal Cell
C37154	Neoplastic_Perineurial_Cell	Neoplastic_Perineural_Cell	Neoplastic Perineurial Cell
C37155	Neoplastic_Meningothelial_Cell	Neoplastic_Cell	Neoplastic Meningothelial Cell|Neoplastic Arachnoidal Cell
C37156	Spindle-Shaped_Meningothelial_Cell	Neoplastic_Meningothelial_Cell	Spindle-Shaped Meningothelial Cell
C37157	Meningothelial_Cell_with_Elongated_Processes	Neoplastic_Meningothelial_Cell	Meningothelial Cell with Elongated Processes
C37158	Pleomorphic_Meningothelial_Cell	Neoplastic_Meningothelial_Cell	Pleomorphic Meningothelial Cell
C37159	Eosinophilic_Meningothelial_Cell	Neoplastic_Meningothelial_Cell	Eosinophilic Meningothelial Cell
C37160	Meningothelial_Cell_with_Clear_Cytoplasm	Neoplastic_Meningothelial_Cell	Meningothelial Cell with Clear Cytoplasm
C37161	Small_Meningothelial_Cell	Neoplastic_Meningothelial_Cell	Small Meningothelial Cell
C37162	Neoplastic_Large_Cell	Neoplastic_Cell	Neoplastic Large Cell
C37163	Neoplastic_Large_Cell_with_Abundant_Pale_Cytoplasm	Neoplastic_Large_Cell_with_Abundant_Cytoplasm	Neoplastic Large Cell with Abundant Pale Cytoplasm
C37164	Neoplastic_Polygonal_Cell_with_Eosinophilic_Cytoplasm	Neoplastic_Cell_with_Eosinophilic_Cytoplasm|Neoplastic_Polygonal_Cell	Neoplastic Polygonal Cell with Eosinophilic Cytoplasm
C37165	Atypical_Lymphocyte	Abnormal_Lymphocyte	Atypical Lymphocyte
C37166	Neoplastic_Eosinophilic_Cell_Oncocyte	Neoplastic_Cell_with_Eosinophilic_Cytoplasm|Neoplastic_Oncocyte	Neoplastic Eosinophilic Cell Oncocyte
C37167	Malignant_Eosinophilic_Cell_Oncocyte	Malignant_Oncocyte|Neoplastic_Eosinophilic_Cell_Oncocyte	Malignant Eosinophilic Cell Oncocyte
C37168	Metaplastic_Myoepithelial_Cell	Metaplastic_Cell	Metaplastic Myoepithelial Cell
C37169	Multilobated_Neoplastic_B-Lymphocyte	Neoplastic_Large_B-Lymphocyte	Multilobated Neoplastic B-Lymphocyte
C37170	Pleomorphic_Epithelial_Cell	Malignant_Epithelial_Cell|Pleomorphic_Cell	Pleomorphic Epithelial Cell
C37171	Pleomorphic_Adenocarcinoma_Cell	Adenocarcinoma_Cell|Pleomorphic_Epithelial_Cell	Pleomorphic Adenocarcinoma Cell
C37172	Hypolobated_Neutrophil	Dysplastic_Neutrophil	Hypolobated Neutrophil
C37173	Neutrophil_with_Abnormal_Cytoplasmic_Granulation	Dysplastic_Neutrophil	Neutrophil with Abnormal Cytoplasmic Granulation
C37174	Neutriphil_with_Cytoplasmic_Hypogranularity	Neutrophil_with_Abnormal_Cytoplasmic_Granulation	Neutrophil with Cytoplasmic Hypogranularity
C37175	Neutriphil_with_pseudo_Chediak-Higashi_Granules	Neutrophil_with_Abnormal_Cytoplasmic_Granulation	Neutrophil with pseudo Chediak-Higashi Granules
C37176	Neoplastic_Myeloblast_with_Abundant_Basophilic_Cytoplasm	Neoplastic_Blast_with_Basophilic_Cytoplasm	Neoplastic Myeloblast with Abundant Basophilic Cytoplasm
C37177	Neoplastic_Medium-Sized_Myeloblast_with_Basophilic_Agranular_Cytoplasm	Neoplastic_Blast_with_Basophilic_Cytoplasm	Neoplastic Medium-Sized Myeloblast with Basophilic Agranular Cytoplasm
C37178	Neoplastic_Myeloblast_with_Azurophilic_Granules	Neoplastic_Myeloblast	Neoplastic Myeloblast with Azurophilic Granules
C37179	Neoplastic_Myeloblast_without_Azurophilic_Granules	Neoplastic_Myeloblast	Neoplastic Myeloblast without Azurophilic Granules
C37180	Medium-Sized_Neoplastic_Blast_with_Coarse_Cytoplasmic_Basophilic_Granules	Neoplastic_Myeloblast	Medium-Sized Neoplastic Myeloblast with Coarse Cytoplasmic Basophilic Granules
C37181	Neoplastic_Monoblast	Neoplastic_Myeloid_Blast	Neoplastic Monoblast
C37182	Neoplastic_Prolymphocyte	Leukemic_Lymphocyte	Neoplastic Prolymphocyte
C37183	Neoplastic_B-Prolymphocyte	Neoplastic_B-Lymphocyte|Neoplastic_Prolymphocyte	Neoplastic B-Prolymphocyte
C37184	Neoplastic_T-Prolymphocyte	Neoplastic_Prolymphocyte|Neoplastic_T-Lymphocyte	Neoplastic T-Prolymphocyte
C37185	Gain_of_Chromosome_12q13	Chromosomal_Gain	Gain of Chromosome 12q13|Gain in Chromosome 12(q13)
C37188	del_6q25-27	Chromosomal_Deletion	del(6q25-27)
C37189	del_17q25	Chromosomal_Deletion	del(17q25)
C37190	t_9_22_q22-31_q12	Chromosomal_Translocation	t(9;22)(q22-31;q12)
C37191	Trisomy_11	Trisomy	Trisomy 11
C37192	Intravascular_Metastasis	Metastasis	Intravascular Metastasis	Intravascular Metastasis involves transfer of malignant cells via the cardiovascular system from one organ or part to another that is not directly connected with it.
C37193	ALK-Positive_Anaplastic_Large_Cell_Lymphoma	Anaplastic_Large_Cell_Lymphoma	ALK-Positive Anaplastic Large Cell Lymphoma|ALKoma
C37194	ALK-Negative_Anaplastic_Large_Cell_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|Anaplastic_Large_Cell_Lymphoma	ALK-Negative Anaplastic Large Cell Lymphoma
C37195	Primary_Systemic_ALK-Positive_Anaplastic_Large_Cell_Lymphoma	ALK-Positive_Anaplastic_Large_Cell_Lymphoma|Systemic_Anaplastic_Large_Cell_Lymphoma	Primary Systemic ALK-Positive Anaplastic Large Cell Lymphoma|Primary Systemic ALK-Positive ALCL|Primary Systemic ALKoma
C37196	Primary_Systemic_ALK-Negative_Anaplastic_Large_Cell_Lymphoma	ALK-Negative_Anaplastic_Large_Cell_Lymphoma|Systemic_Anaplastic_Large_Cell_Lymphoma	Primary Systemic ALK-Negative Anaplastic Large Cell Lymphoma	A CD30 (Ki-1)-positive anaplastic large cell lymphoma with cytoplasmic and/or nuclear expression of the ALK (anaplastic lymphoma kinase) protein.  It usually affects both the lymph nodes and extranodal sites (primarily skin, bones, lungs, and soft tissues), and has been associated with a favorable clinical outcome. -- 2004
C37197	Pure_Bronchiolo-Alveolar_Lung_Carcinoma	Retired_Concepts	Pure Bronchiolo-Alveolar Lung Carcinoma|Pure BAC
C37198	Mixed_Adenocarcinoma-Bronchiolo-Alveolar_Lung_Carcinoma	Retired_Concepts	Mixed Adenocarcinoma-Bronchiolo-Alveolar Lung Carcinoma|AD-BAC
C37199	Lung_Papillary-Adenocarcinoma	Retired_Concepts	Lung Papillary-Adenocarcinoma|Lung PAP-AD
C37200	t_16_17_q22_p13	Chromosomal_Translocation	t(16;17)(q22;p13)
C37201	Chronic_Lymphocytic_Leukemia_Small_Lymphocytic_Lymphoma_with_Immunoglobulin_Heavy_Chain_Variable-Region_Gene_Somatic_Hypermutation	Chronic_Lymphocytic_Leukemia_Small_Lymphocytic_Lymphoma	Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation|CLL/SLL with IGVH SHM|Postgerminal Center Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma	A recently recognized variant of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) expressing somatic hypermutations of the Immunoglobulin heavy chain (IGH) genes.  The recognition of this variant alters the belief that CLL/SLL is always derived from a naive, pregerminal center B-cell.  The presence of somatic hypermutations of IGH genes occurs in approximately 50% of CLL/SLL cases and implies a postgerminal center, memory origin.  Patients with this variant of CLL/SLL have a favorable prognosis, with a reported median survival of more than 24 years. -- 2004
C37202	Chronic_Lymphocytic_Leukemia_with_Immunoglobulin_Heavy_Chain_Variable-Region_Gene_Somatic_Hypermutation	Chronic_Lymphocytic_Leukemia|Chronic_Lymphocytic_Leukemia_Small_Lymphocytic_Lymphoma_with_Immunoglobulin_Heavy_Chain_Variable-Region_Gene_Somatic_Hypermutation	Chronic Lymphocytic Leukemia with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation|CLL with IGVH SHM|Postgerminal Center Chronic Lymphocytic Leukemia
C37203	Small_Lymphocytic_Lymphoma_with_Immunoglobulin_Heavy_Chain_Variable-Region_Gene_Somatic_Hypermutation	Chronic_Lymphocytic_Leukemia_Small_Lymphocytic_Lymphoma_with_Immunoglobulin_Heavy_Chain_Variable-Region_Gene_Somatic_Hypermutation|Indolent_Non-Hodgkin_s_Lymphoma|Small_Lymphocytic_Lymphoma	Small Lymphocytic Lymphoma with Immunoglobulin Heavy Chain Variable-Region Gene Somatic Hypermutation|Postgerminal Center Small Lymphocytic Lymphoma|SLL with IGVH SH
C37204	Chronic_Lymphocytic_Leukemia_Small_Lymphocytic_Lymphoma_with_Unmutated_Immunoglobulin_Heavy_Chain-Region_Gene	Chronic_Lymphocytic_Leukemia_Small_Lymphocytic_Lymphoma	Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene|CLL/SLL with Unmutated IGVH|Pregerminal Center Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma	A recently recognized variant of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) that lacks somatic hypermutations of the Immunoglobulin heavy chain (IGH) genes, implying pregerminal center B-cell origin.  Microarray gene expression profiling studies have demonstrated the expression of ZAP-70 gene (Syk family tyrosine kinase) in this subset of CLL/CLL.  Patients with this variant of CLL/SLL have an unfavorable prognosis compared to those with somatic hypermutations of the IGH genes, with a median survival of approximately 6-8 years. --2004
C37205	Chronic_Lymphocytic_Leukemia_with_Unmutated_Immunoglobulin_Heavy_Chain-Region_Gene	Chronic_Lymphocytic_Leukemia|Chronic_Lymphocytic_Leukemia_Small_Lymphocytic_Lymphoma_with_Unmutated_Immunoglobulin_Heavy_Chain-Region_Gene	Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene|CLL with Unmutated IGVH|Pregerminal Center Chronic Lymphocytic Leukemia
C37206	Small_Lymphocytic_Lymphoma_with_Unmutated_Immunoglobulin_Heavy_Chain-Region_Gene	Chronic_Lymphocytic_Leukemia_Small_Lymphocytic_Lymphoma_with_Unmutated_Immunoglobulin_Heavy_Chain-Region_Gene|Small_Lymphocytic_Lymphoma	Small Lymphocytic Lymphoma with Unmutated Immunoglobulin Heavy Chain Variable-Region Gene|Pregerminal Center Small Lymphocytic Lymphoma|SLL with Unmutated IGVH
C37207	ZAP-70_Messenger_RNA_Overexpression	Messenger_RNA_Overexpression	ZAP-70 Messenger RNA Overexpression|ZAP-70 mRNA Overexpression|Zeta-Associated Protein-70 Messenger RNA Overexpression|Zeta-Associated Protein-70 mRNA Overexpression
C37208	Rearrangement_of_2p23	Chromosomal_Rearrangement	Rearrangement of 2p23
C37209	Blastoid_Follicular_Lymphoma	Follicular_Lymphoma	Blastoid Follicular Lymphoma	A recently described distinct subtype of high-grade follicular center cell lymphoma, representing a transformation of conventional follicular lymphomas.  Although this type of lymphoma strongly expresses BCL-2, it does not carry the characteristic t(14;18)(q32;q21) chromosomal translocation found in follicular lymphomas.  Instead, extra copies of chromosome 18 are often detected. -- 2004
C37210	Renal_Neoplasm_with_t_6_11_p21_q12	Renal_Neoplasm	Renal Neoplasm with t(6;11)(p21;q12)	A distinctive epithelioid renal neoplasm often affecting young patients, bearing a characteristic t(6;11)(p21;q12) chromosomal translocation resulting in Alpha-TFEB gene fusion. -- 2004
C37211	t_6_11_p21_q12	Chromosomal_Translocation	t(6;11)(p21;q12)
C37212	Solid_Pseudopapillary_Tumor_of_the_Pancreas	Borderline_Exocrine_Pancreatic_Neoplasm	Solid Pseudopapillary Tumor of the Pancreas|Solid Pseudopapillary Neoplasm of the Pancreas
C37213	Intraductal_Pancreatic_Mucinous_Neoplasm	Retired_Concepts	Pancreatic Intraductal Mucinous Neoplasm
C37214	Colloid_Carcinoma_of_the_Pancreas	Pancreatic_Ductal_Adenocarcinoma	Pancreatic Mucinous Noncystic Carcinoma|Colloid Carcinoma of the Pancreas	A pancreatic adenocarcinoma, clinicopathologically distinct from conventional pancreatic ductal adenocarcinomas, with a relatively indolent behavior (5-year survival of 55%).  It often arises in association with intraductal pancreatic mucinous neoplasms. -- 2004
C37215	Intraductal_Papillary_Mucinous_Neoplasm_of_the_Biliary_Tract	Bile_Duct_Neoplasm	Intraductal Papillary Mucinous Neoplasm of the Biliary Tract
C37216	CLTC-ALK_Fusion_Protein_Expression	Fusion_Protein_Expression	CLTC-ALK Fusion Protein Expression
C37217	FIP1L1-PDGFRalpha_Fusion_Protein_Expression	Fusion_Protein_Expression	FIP1L1-PDGFRalpha Fusion Protein Expression
C37218	AML1-ETO_Fusion_Protein_Expression	Fusion_Protein_Expression	AML1-ETO Fusion Protein Expression|CBFalpha2-ETO Fusion Protein Expression
C37219	CBFbeta-MYH11_Fusion_Protein_Expression	Fusion_Protein_Expression	CBFbeta-MYH11 Fusion Protein Expression
C37220	PLZF-RARalpha_Fusion_Protein_Expression	Fusion_Protein_Expression	PLZF-RARalpha Fusion Protein Expression
C37221	NPM-RARalpha_Fusion_Protein_Expression	Fusion_Protein_Expression	NPM-RARalpha Fusion Protein Expression
C37222	NuMA-RARalpha_Fusion_Protein_Expression	Fusion_Protein_Expression	NuMA-RARalpha Fusion Protein Expression
C37223	PML-RARalpha_Fusion_Protein_Expression	Fusion_Protein_Expression	PML-RARalpha Fusion Protein Expression
C37224	EWS-FL1_Fusion_Protein_Expression	Fusion_Protein_Expression	EWS-FL1 Fusion Protein Expression
C37226	E2A-PBX1_Fusion_Protein_Expression	Fusion_Protein_Expression	E2A-PBX1 Fusion Protein Expression
C37227	TEL-AML1_Fusion_Protein_Expression	Fusion_Protein_Expression	TEL-AML1 Fusion Protein Expression|ETV6-CBFalpha2 Fusion Protein Expression
C37228	MLL-AF4_Fusion_Protein_Expression	Fusion_Protein_Expression	MLL-AF4 Fusion Protein Expression|MLL-FEL Fusion Protein Expression
C37229	EWS-ERG_Fusion_Protein_Expression	Fusion_Protein_Expression	EWS-ERG Fusion Protein Expression
C37230	EWS-ETV1_Fusion_Protein_Expression	Fusion_Protein_Expression	EWS-ETV1 Fusion Protein Expression
C37231	EWS-E1AF_Fusion_Protein_Expression	Fusion_Protein_Expression	EWS-E1AF Fusion Protein Expression
C37232	EWS-ATF1_Fusion_Protein_Expression	Fusion_Protein_Expression	EWS-ATF1 Fusion Protein Expression
C37234	EWS-NR4A3_Fusion_Protein_Expression	Fusion_Protein_Expression	EWS-NR4A3 Fusion Protein Expression|EWS-CHN Fusion Protein Expression
C37235	RBP56-NR4A3_Fusion_Protein_Expression	Fusion_Protein_Expression	RBP56-NR4A3 Fusion Protein Expression|RBP56-CHN Fusion Protein Expression
C37236	TCF12-NR4A3_Fusion_Protein_Expression	Fusion_Protein_Expression	TCF12-NR4A3 Fusion Protein Expression|TCF12-CHN Fusion Protein Expression
C37237	EWS-WT1_Fusion_Protein_Expression	Fusion_Protein_Expression	EWS-WT1 Fusion Protein Expression
C37238	FUS-DDIT3_Fusion_Protein_Expression	Fusion_Protein_Expression	FUS-DDIT3 Fusion Protein Expression|FUS-CHOP Fusion Protein Expression
C37239	PAX3-FKHR_Fusion_Protein_Expression	Fusion_Protein_Expression	PAX3-FKHR Fusion Protein Expression
C37240	PAX7-FKHR_Fusion_Protein_Expression	Fusion_Protein_Expression	PAX7-FKHR Fusion Protein Expression
C37241	COL1A2-PLAG1_Fusion_Protein_Expression	Fusion_Protein_Expression	COL1A2-PLAG1 Fusion Protein Expression
C37242	HAS2-PLAG1_Fusion_Protein_Expression	Fusion_Protein_Expression	HAS2-PLAG1 Fusion Protein Expression
C37243	ETV6-NTRK3_Fusion_Protein_Expression	Fusion_Protein_Expression	ETV6-NTRK3 Fusion Protein Expression
C37244	FUS-ATF1_Fusion_Protein_Expression	Fusion_Protein_Expression	FUS-ATF1 Fusion Protein Expression
C37245	SS18-SSX1_Fusion_Protein_Expression	SS18-SSX_Fusion_Protein_Expression	SS18-SSX1 Fusion Protein Expression|SSXT-SSX1 Fusion Protein Expression|SYT-SSX1 Fusion protein Expression
C37246	SS18-SSX2_Fusion_Protein_Expression	SS18-SSX_Fusion_Protein_Expression	SS18-SSX2 Fusion Protein Expression|SSXT-SSX2 Fusion Protein Expression|SYT-SSX2 Fusion Protein Expression
C37247	SS18-SSX4_Fusion_Protein_Expression	SS18-SSX_Fusion_Protein_Expression	SS18-SSX4 Fusion Protein Expression|SSXT-SSX4 Fusion Protein Expression|SYT-SSX4 Fusion Protein Expression
C37248	ASPL-TFE3_Fusion_Protein_Expression	Fusion_Protein_Expression	ASPL-TFE3 Fusion Protein Expression|ASPSCR1-TFE3 Fusion Protein Expression|RCC17-TFE3 Fusion Protein Expression
C37249	t_2_22_q13_q22_t_3_18_p21_q23	Chromosomal_Translocation	t(2;22)(q33;q12)
C37250	EWS-FEV_Fusion_Protein_Expression	Fusion_Protein_Expression	EWS-FEV Fusion Protein Expression
C37251	t_1_22_p36_1_q12	Chromosomal_Translocation	t(1;22)(p36.1;q12)
C37252	EWS-ZSG_Fusion_Protein_Expression	Fusion_Protein_Expression	EWS-ZSG Fusion Protein Expression
C37253	HMGIC-LPP_Fusion_Protein_Expression	Fusion_Protein_Expression	HMGIC-LPP Fusion Protein Expression
C37254	Cardiovascular_System_Signs_and_Symptoms	Symptom	Cardiovascular System Signs and Symptoms
C37255	Atypical_Squamous_Cell_cannot_exclude_a_High_Grade_Lesion	Atypical_Squamous_Cell	Atypical Squamous Cell, cannot exclude a High Grade Lesion|ASC-H
C37256	Pancreatic_Foamy_Gland_Adenocarcinoma	Pancreatic_Adenocarcinoma	Pancreatic Foamy Gland Adenocarcinoma
C37257	Desmoplastic_Melanoma	Cutaneous_Melanoma|Spindle_Cell_Melanoma	Desmoplastic Melanoma
C37258	Paraganglioma-Like_Dermal_Melanocytic_Tumor	Benign_Dermal_Neoplasm	Paraganglioma-Like Dermal Melanocytic Tumor
C37259	Benign_Pilomatrixoma	Retired_Concepts	Benign Pilomatrixoma|Benign Pilomatricoma
C37260	Classic_Lymphocytic_Colitis	Lymphocytic_Colitis	Classic Lymphocytic Colitis
C37261	Hermansky-Pudlak_Syndrome	Syndrome	Hermansky-Pudlak Syndrome
C37262	Granulomatous_Colitis	Colitis	Granulomatous Colitis
C37263	Mixed_Epithelial_Stromal_Tumor_of_the_Kidney	Mixed_Neoplasm|Renal_Neoplasm	Mixed Epithelial Stromal Tumor of the Kidney|Adult Mesoblastic Nephroma|MEST
C37264	Benign_Mixed_Epithelial_Stromal_Tumor_of_the_Kidney	Benign_Renal_Neoplasm|Mixed_Epithelial_Stromal_Tumor_of_the_Kidney	Benign Mixed Epithelial Stromal Tumor of the Kidney|Benign MEST
C37265	Malignant_Mixed_Epithelial_Stromal_Tumor_of_the_Kidney	Malignant_Mixed_Neoplasm|Malignant_Renal_Neoplasm|Mixed_Epithelial_Stromal_Tumor_of_the_Kidney	Malignant Mixed Epithelial Stromal Tumor of the Kidney|Malignant MEST
C37266	Bladder_Flat_Intraepithelial_Lesion	Bladder_Neoplasm|Intraurothelial_Neoplasia	Bladder Flat Intraepithelial Lesion|Flat Intraepithelial Lesion of the Bladder|Flat Intraepithelial Lesion of the Urinary Bladder|Urinary Bladder Flat Intraepithelial Lesion
C37267	Bladder_Flat_Carcinoma_in_Situ	Retired_Concepts	Bladder Flat Carcinoma in Situ|Bladder Flat CIS|Flat CIS of the Bladder|Flat CIS of the Urinary Bladder|Flat Carcinoma in Situ of the Bladder|Flat Carcinoma in Situ of the Urinary Bladder|Urinary Bladder Flat CIS|Urinary Bladder Flat Carcinoma in Situ
C37268	Atypical_Small_Acinar_Proliferation_of_the_Prostate_Gland	Prostate_Neoplasm	Atypical Small Acinar Proliferation of the Prostate Gland|ASAP|Prostatic Atypical Small Acinar Proliferation
C37269	Morular_Metaplasia_of_the_Endometrium	Squamous_Metaplasia	Morular Metaplasia of the Endometrium|MM|Morular Metaplasia
C37270	Endometrial_Glandular_Dysplasia	Retired_Concepts	Endometrial Glandular Dysplasia|EmGD
C37271	Tyrosine_Phosphatase_SHP_Substrate-1	Cell_Surface_Receptor	Tyrosine Phosphatase SHP Substrate-1|BIT|Brain Ig-Like Molecule with Tyrosine-Based Activation Motifs|Inhibitory Receptor SHPS-1|MFR|MYD-1 Antigen|MYD1|Macrophage Fusion Receptor|PTPNS1|Protein Tyrosine Phosphatase Non-Receptor Type Substrate 1|SHP Substrate-1|SHPS1|SIRP|SIRP Alpha|SIRP Alpha 1|SIRP Alpha 2|SIRP Alpha 3|Signal Regulatory Protein Alpha Type 1|Signal Regulatory Protein Alpha Type 2|Signal-Regulatory Protein Alpha-1|p84	Encoded as 3 isoforms by human PTPNS1 Gene (SIRP/Ig Families), ubiquitous (high in brain) N-glycosylated Tyrosine Phosphatase SHP Substrate 1 is a type I membrane protein cell surface CD47 receptor that contains an Ig-V-type and 2 Ig-C1-type domains. A negative receptor tyrosine kinase regulator to cell adhesion, growth factors, or insulin and phosphorylated by receptor signal transduction, PTPNS1 recruits SH2 domain PTPs as signaling PTP substrates. PTPNS1 induces membrane translocation of PTPN6, -11, and other cytosolic partners; negatively regulates phagocytosis, mast cell activation, and dendritic cell activation/maturation; and regulates neural adhesion, neurite outgrowth, glial attachment, synaptogenesis, and synaptic function. Dephosphorylated by PTPN11 (PTPN6 in macrophages), PTPNS1 appears to bind GRB2, PTK2B, and FGR; forms a stable complex with JAK2; and binds SCAP1/SCAP2, recruiting FYB. (NCI)
C37272	Simplex_Differentiated_Type_of_Vulvar_Intraepithelial_Neoplasia	Vulvar_Intraepithelial_Neoplasia	Simplex (Differentiated) Vulvar Intraepithelial Neoplasia|Differentiated Vulvar Intraepithelial Neoplasia|SxVIN|d-VIN|dVIN
C37273	Protein_Tyrosine_Phosphatase-IVA1	Protein_Tyrosine_Phosphatase	Protein Tyrosine Phosphatase-IVA1|HH72|PRL1|PTP4A1|PTPCAAX1|Protein Tyrosine Phosphatase PTPCAAX1|Protein Tyrosine Phosphatase Type IVA Member 1	Encoded by human PTP4A1 Gene (PTP Family), Protein Tyrosine Phosphatase IVA1 is a regulatory cell signaling nuclear tyrosine phosphatase primarily associated with the plasma membrane that belongs to a small class of prenylated PTPs, contains a PTP domain and a characteristic C-terminal prenylation motif, and may be an immediate-early gene product in mitogen-stimulated cells. The surface membrane association of PTP4A1 depends on C-terminal prenylation. (NCI)
C37274	Interferon_Alpha_Receptor_Complex	Protein_or_Riboprotein_Complex	Interferon Alpha Receptor Complex|Interferon Alpha Receptor|Interferon Beta Receptor|Interferon-Alpha-Beta Receptor	Human Interferon Alpha Receptor Complex (Type II Cytokine Family Receptor) is a ubiquitous type I membrane protein heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. (NCI)
C37275	IFNAR1_Gene	Cytokine_Receptor_Gene	IFNAR1 Gene|IFNAR|IFNAR1|Interferon (Alpha, Beta and Omega) Receptor 1 Gene	Human IFNAR1 Gene (Type II Cytokine Receptor Family) encodes 557-aa 64-kDa (precursor) ubiquitous type I membrane protein Interferon Alpha-Beta Receptor Alpha Chain, containing 3 fibronectin type III domains and the alpha subunit of Interferon Alpha Receptor Complex, a heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. (NCI)
C37276	Interferon_Alpha-Beta_Receptor_Alpha_Chain	Cytokine_Receptor	Interferon Alpha-Beta Receptor Alpha Chain|AVP|Alpha-Beta-Omega Interferon Receptor-1|Antiviral Protein Alpha Type|HuIFN-Alpha-Rec|IFN-Alpha-REC|IFNBR|IFRC|Interferon Alpha Receptor	Encoded by human IFNAR1 Gene (Type II Cytokine Receptor Family), 557-aa 64-kDa (precursor) ubiquitous type I membrane protein Interferon Alpha-Beta Receptor Alpha Chain contains 3 fibronectin type III domains and is the alpha subunit of Interferon Alpha Receptor Complex, a heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. (NCI)
C37277	IFNAR2_Gene	Cytokine_Receptor_Gene	IFNAR2 Gene|IFNAR2|IFNARB|Interferon (Alpha, Beta and Omega) Receptor 2 Gene	Human IFNAR2 Gene (Type II Cytokine Receptor Family) encodes 515-aa 58-kDa (precursor), 331-aa, and 515-aa isoforms of ubiquitous type I membrane protein Interferon Alpha-Beta Receptor Beta Chain, the beta subunit of Interferon Alpha Receptor Complex, a heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. IFNAR2 interacts with RACK1. (NCI)
C37278	Interferon_Alpha-Beta_Receptor_Beta_Chain	Cytokine_Receptor	Interferon Alpha-Beta Receptor Beta Chain|Alpha-Beta-Omega Interferon Receptor-2|IFN-Alpha-REC|IFN-R|IFNABR|Interferon Alpha-Beta Receptor|Interferon Alpha-Beta Receptor-2|Type I Interferon Receptor	Encoded as 515-aa 58-kDa (precursor), 331-aa, and 515-aa isoforms by human IFNAR2 Gene (Type II Cytokine Receptor Family), ubiquitous type I membrane protein Interferon Alpha-Beta Receptor Beta Chain is the beta subunit of Interferon Alpha Receptor Complex, a heteromeric receptor for type I IFNs, alpha and beta, composed of at least 2 chains, IFNAR1 (alpha chain) and IFNAR2 (beta chain). In mediating innate immune responses to viral infection and specific interferon inhibition of virus replication, binding of alpha and beta IFNs triggers tyrosine phosphorylation of JAKs, TYK2, STAT proteins, autophosphorylation, and tyrosine phosphorylation by TYK2. IFNAR2 interacts with RACK1. (NCI)
C37279	Interferon_Gamma_Receptor_Complex	Protein_or_Riboprotein_Complex	Interferon Gamma Receptor Complex|IFN-Gamma Receptor	Expressed in monocytes, lymphocytes, and placenta, human Interferon Gamma Receptor Complex (Type II Cytokine Family Receptor) is a Ser/Thr phosphorylated type I membrane protein heteromeric receptor for IFN-gamma, composed of IFNGR1 and IFNGR2, that activates macrophages in host defenses. In mediating innate immune responses to viral infection, binding of IFN-gamma activates JAK kinases leading to tyrosine phosphorylation of STAT1 and STAT2. IFNGR1 constitutes the receptor ligand-binding alpha chain while the integral accessory factor IFNGR2 is required for signal transduction and may interact with GAF, JAK1, and/or JAK2. (NCI)
C37280	IFNGR1_Gene	Cytokine_Receptor_Gene	IFNGR1 Gene|IFNGR|IFNGR1|Interferon Gamma Receptor 1 Gene	Expressed as a 2.3-kb transcript in monocytes, lymphocytes, and placenta, human IFNGR1 Gene (Type II Cytokine Receptor Family) encodes monomeric 489-aa 90-kDa type I membrane protein Interferon Gamma Receptor Alpha Chain, a subunit of Ser/Thr phosphorylated heteromeric Interferon Gamma Receptor Complex, composed of IFNGR1 and IFNGR2, that activates macrophages in host defenses. Containing an N-terminal signal peptide, 7 potential N-linked glycosylation sites, several potential Ser- and Thr-rich O-linked glycosylation sites, 2 fibronectin type III domains, 2 Ig-like C2-type domains, a transmembrane domain, and a cytoplasmic portion, IFNGR1 acts as the receptor ligand-binding subunit. IFNGR2 constitutes an integral receptor accessory factor required for signal transduction. Defects in IFNGR1 are a cause of FDAMI. (NCI)
C37281	_6q23-q24	Chromosome_Band	6q23-q24	A chromosome band present on 6q
C37282	_10q22	Chromosome_Band	10q22	A chromosome band present on 10q
C37283	_8p11_2	Chromosome_Band	8p11.2	A chromosome band present on 8p
C37284	_Xq24-q26	Chromosome_Band	Xq24-q26	A chromosome band present on Xq
C37285	_Xp22_32	Chromosome_Band	Xp22.32	A chromosome band present on Xp
C37286	Interferon_Gamma_Receptor_Alpha_Chain	Cytokine_Receptor	Interferon Gamma Receptor Alpha Chain|CD119|CD119 Antigen|CDw119|IFN-Gamma-R1|Immune Interferon Receptor|Interferon Gamma Receptor-1	Expressed in monocytes, lymphocytes, and placenta by human IFNGR1 Gene (Type II Cytokine Receptor Family), monomeric 489-aa 90-kDa type I membrane protein Interferon Gamma Receptor Alpha Chain is a subunit of Ser/Thr phosphorylated heteromeric Interferon Gamma Receptor Complex, composed of IFNGR1 and IFNGR2, that activates macrophages in host defenses. Containing an N-terminal signal peptide, 7 potential N-linked glycosylation sites, several potential Ser- and Thr-rich O-linked glycosylation sites, 2 fibronectin type III domains, 2 Ig-like C2-type domains, a transmembrane domain, and a cytoplasmic portion, IFNGR1 acts as the receptor ligand-binding subunit. IFNGR2 constitutes an integral receptor accessory factor required for signal transduction. Defects in IFNGR1 are a cause of FDAMI. (NCI)
C37287	IFNGR2_Gene	Cytokine_Receptor_Gene	IFNGR2 Gene|IFNGR2|IFNGT1|Interferon Gamma Receptor 2 (Interferon Gamma Transducer 1) Gene	Expressed from multiple transcription start sites (absent TATA and CAAT boxes), 33-kb 7-exon human IFNGR2 Gene (Type II Cytokine Receptor Family), encodes 337-aa 38-kDa (precursor) type I membrane protein Interferon Gamma Receptor Beta Chain, an integral accessory factor subunit of Interferon Gamma Receptor Complex required for signal transduction. Ser/Thr phosphorylated IFN Gamma Receptor activates macrophages in innate immune responses to viral infection and host defenses. Ligand-bound receptor activates JAK kinases leading to tyrosine phosphorylation of STAT1 and STAT2. IFNGR1 constitutes the receptor ligand-binding alpha chain. Containing 2 fibronectin type III domains, IFNGR2 may interact with GAF, JAK1, and/or JAK2. (NCI)
C37288	Interferon_Gamma_Receptor_Beta_Chain	Cell_Surface_Receptor	Interferon Gamma Receptor Beta Chain|AF-1|IFGR2|Interferon Gamma Receptor Accessory Factor-1|Interferon Gamma Receptor-2|Interferon Gamma Transducer-1	Encoded by human IFNGR2 Gene (Type II Cytokine Receptor Family), 337-aa 38-kDa (precursor) type I membrane protein Interferon Gamma Receptor Beta Chain is an integral accessory factor subunit of Interferon Gamma Receptor Complex required for signal transduction. Ser/Thr phosphorylated IFN Gamma Receptor activates macrophages in innate immune responses to viral infection and host defenses. Ligand-bound receptor activates JAK kinases leading to tyrosine phosphorylation of STAT1 and STAT2. IFNGR1 constitutes the receptor ligand-binding alpha chain. Containing 2 fibronectin type III domains, IFNGR2 may interact with GAF, JAK1, and/or JAK2. (NCI)
C37289	Voltage-Dependant_Anion_Channel	Ion_Channel_Protein	Voltage-Dependant Anion Channel	The Voltage-Dependent Anion Channel (VDAC) is a small, abundant pore-forming eukaryotic protein in the outer mitochondrial membrane thought to form the major pathway for movement of adenine nucleotides through the outer membrane and to be the mitochondrial binding site for hexokinase and glycerol kinase. (NCI)
C37290	Head_and_Neck_Basaloid_Squamous_Cell_Carcinoma	Basaloid_Carcinoma|Head_and_Neck_Squamous_Cell_Carcinoma	Head and Neck Basaloid Carcinoma|Basaloid Squamous Cell Carcinoma of Head and Neck|Basaloid Squamous Cell Carcinoma of the Head and Neck|Head and Neck Basaloid Squamous Cell Carcinoma
C37291	VDAC1_Gene	Ion_Channel_Protein_Gene	VDAC1 Gene|VDAC|VDAC1|Voltage-Dependent Anion Channel 1 Gene	Expressed in heart, liver, and skeletal muscle, 9-exon human VDAC1 Gene (Mitochondrial Porin Family) encodes ubiquitous 282-aa 31-kDa Voltage-Dependent Anion Channel-1 protein, consisting mainly of membrane-spanning beta-sheets that form a channel in the outer mitochondrial membrane and plasma membrane that adopts transmembrane voltage-dependent open/closed conformations and allows diffusion of small hydrophilic molecules. In response to apoptotic signal transduction, BCL2 proteins regulate cell death by controlling mitochondrial membrane permeability during apoptosis; BCLXL binds to and closes VDAC. Proapoptotic BAX and BAK accelerate VDAC opening, allowing cytochrome C to pass through VDAC, which activates death-driving proteolytic caspases. (NCI)
C37292	Voltage-Dependent_Anion_Channel-1	Voltage-Dependant_Anion_Channel	Voltage-Dependent Anion Channel-1|Outer Mitochondrial Membrane Protein Porin-1|Plasmalemmal Porin|Porin|Porin 31HL|Porin 31HM|VDAC-1|Voltage-Dependent Anion-Selective Channel Protein-1|hVDAC1	Expressed in heart, liver, and skeletal muscle by human VDAC1 Gene (Mitochondrial Porin Family), ubiquitous 282-aa 31-kDa Voltage-Dependent Anion Channel-1 protein consists mainly of membrane-spanning beta-sheets that form a channel in the mitochondrial outer membrane and plasma membrane that adopts transmembrane voltage-dependent open/closed conformations and allows diffusion of small hydrophilic molecules. In response to apoptotic signal transduction, BCL2 proteins regulate cell death by controlling mitochondrial membrane permeability during apoptosis; BCLXL binds to and closes VDAC. Proapoptotic BAX and BAK accelerate VDAC opening, allowing cytochrome C to pass through VDAC, which activates death-driving proteolytic caspases. (NCI)
C37293	VDAC2_Gene	Ion_Channel_Protein_Gene	VDAC2 Gene|VDAC2|Voltage-Dependent Anion Channel-2 Gene	Human VDAC2 Gene (Mitochondrial Porin Family) encodes 4 isoforms of Voltage-Dependent Anion Channel-2 protein, consisting mainly of membrane-spanning beta-sheets that form a channel in the outer mitochondrial membrane that adopts transmembrane voltage-dependent open/closed conformations and allows diffusion of small hydrophilic molecules. VDAC2 interacts specifically with inactive BAK, preventing BAK activation and inhibiting the mitochondrial apoptotic pathway. Apoptotic signals activate BH3-molecules such as tBID, BIM, or BAD, which displace VDAC2 from BAK, enabling BAK homooligomerization and apoptosis. VDAC2 is also the mitochondrial binding site of metabolic enzymes hexokinase and glycerol kinase. (NCI)
C37294	Voltage-Dependent_Anion_Channel-2	Voltage-Dependant_Anion_Channel	Voltage-Dependent Anion Channel-2|Outer Mitochondrial Membrane Protein Porin-2|VDAC-2|Voltage-Dependent Anion-Selective Channel Protein-2|hVDAC2	Encoded as 4 isoforms by human VDAC2 Gene (Mitochondrial Porin Family), Voltage-Dependent Anion Channel-2 protein consists mainly of membrane-spanning beta-sheets that form a channel in the outer mitochondrial membrane that adopts transmembrane voltage-dependent open/closed conformations and allows diffusion of small hydrophilic molecules. VDAC2 interacts specifically with inactive BAK, preventing BAK activation and inhibiting the mitochondrial apoptotic pathway. Apoptotic signals activate BH3-molecules such as tBID, BIM, or BAD, which displace VDAC2 from BAK, enabling BAK homooligomerization and apoptosis. VDAC2 is also the mitochondrial binding site of metabolic enzymes hexokinase and glycerol kinase. (NCI)
C37295	VDAC3_Gene	Ion_Channel_Protein_Gene	VDAC3 Gene|VDAC3|Voltage-Dependent Anion Channel-3 Gene	Widely expressed (highest in testis) as 2 alternative isoforms, human VDAC3 Gene (Mitochondrial Porin Family) encodes Voltage-Dependent Anion Channel-3 protein, consisting mainly of membrane-spanning beta-sheets in the outer mitochondrial membrane forming a channel that allows diffusion of small hydrophilic molecules. (NCI)
C37296	Voltage-Dependent_Anion-Channel-3	Voltage-Dependant_Anion_Channel	Voltage-Dependent Anion Channel-3|Outer Mitochondrial Membrane Protein Porin-3|Voltage-Dependent Anion-Selective Channel Protein-3|hVDAC3	Widely expressed (highest in testis) as 2 alternative isoforms by human VDAC3 Gene (Mitochondrial Porin Family), Voltage-Dependent Anion Channel-3 protein consists mainly of membrane-spanning beta-sheets in the outer mitochondrial membrane forming a channel that allows diffusion of small hydrophilic molecules. (NCI)
C37297	Adenosine_Nucleotide_Transporter	Transport_Protein	Adenosine Nucleotide Transporter	The most abundant mitochondrial protein, Adenine Nucleotide Translocator (ANT), is a homodimer of 30-kD subunits embedded asymmetrically in the inner mitochondrial membrane that forms a gated pore through which ADP is moved from the matrix to the cytoplasm. (NCI)
C37298	SLC25A4_Gene	Transport_Protein_Gene	SLC25A4 Gene|ANT1|SLC25A4|Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 4 Gene	Expressed as a 1.4 kb mRNA in heart, kidney, liver, skeletal muscle, 6-kb 4-exon human SLC25A4 Gene (Mitochondrial Carrier Family) encodes 298-aa 33-kDa homodimeric Adenine Nucleotide Translocator-1, an integral membrane protein embedded asymmetrically in the inner mitochondrial membrane that catalyzes transmembrane exchange of ADP and ATP and determines the rate of ADP/ATP flux between mitochondrion and cytosol. Strongly similar to murine Ant1, ANT1 contains 3 Solcar repeats and the signature RRRMMM motif of nucleotide carriers; six alpha helices form a compact transmembrane domain. Defects in SLC25A4 are a cause of PEO. (NCI)
C37299	Adenine_Nucleotide_Translocator-1	Adenosine_Nucleotide_Transporter	Adenine Nucleotide Translocator-1|ADP-ATP Translocase-1|ANT|ANT1|Heart-Skeletal Muscle ADP-ATP Carrier Protein-T1|Mitochondrial Adenine Nucleotide Translocator Solute Carrier Family 25 Member-4|Skeletal Muscle Adenine Nucleotide Translocator-1|T1	Expressed in heart, kidney, liver, skeletal muscle by human SLC25A4 Gene (Mitochondrial Carrier Family), 298-aa 33-kDa homodimeric Adenine Nucleotide Translocator-1 is an integral membrane protein embedded asymmetrically in the inner mitochondrial membrane that catalyzes transmembrane exchange of ADP and ATP and determines the rate of ADP/ATP flux between mitochondrion and cytosol. Strongly similar to murine Ant1, ANT1 contains 3 solute carrier (Solcar) repeats and the signature RRRMMM motif of nucleotide carriers; six alpha helices form a compact transmembrane domain. Defects in SLC25A4 are a cause of PEO. (NCI)
C37300	SLC25A5_Gene	Transport_Protein_Gene	SLC25A5 Gene|ANT2|SLC25A5|Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 5 Gene	The 4-exon human SLC25A5 Gene (Mitochondrial Carrier Family) encodes 298-aa 33-kDa homodimeric integral membrane protein Adenine Nucleotide Translocator-2, containing 3 Solcar repeats and catalyzing ADP/ATP exchange of across the inner mitochondrial membrane. ANT2 facilitates ADP/ATP exchange between the cytosol and mitochondria. The mitochondrial permeability transition pore (mtPTP) complex, which includes ANT, mediates sudden increase in inner mitochondrial membrane permeability common in apoptosis. (NCI)
C37301	Adenine_Nucleotide_Translocator-2	Adenosine_Nucleotide_Transporter	Adenine Nucleotide Translocator-2|2F1|ADP-ATP Translocase-2|Fibroblast ADP-ATP Carrier Protein|Fibroblast Adenine Nucleotide Translocator-2|Mitochondrial Adenine Nucleotide Translocator Solute Carrier Family 25 Member-5|Solute Carrier Family 25 Member-5|T2|T3	Encoded by human SLC25A5 Gene (Mitochondrial Carrier Family), 298-aa 33-kDa homodimeric integral membrane protein Adenine Nucleotide Translocator-2 contains 3 Solcar repeats and catalyzes ADP/ATP exchange of across the inner mitochondrial membrane. ANT2 facilitates ADP/ATP exchange between the cytosol and mitochondria. The mitochondrial permeability transition pore (mtPTP) complex, which includes ANT, mediates sudden increase in inner mitochondrial membrane permeability common in apoptosis. (NCI)
C37302	SLC25A6_Gene	Transport_Protein_Gene	SLC25A6 Gene|ANT3|SLC25A6|Solute Carrier Family 25 (Mitochondrial Carrier; Adenine Nucleotide Translocator), Member 6 Gene	Human SLC25A6 Gene (Mitochondrial Carrier Family) encodes 298-aa 33-kDa homodimeric integral membrane protein Adenine Nucleotide Translocator-3, containing 3 Solcar repeats, that plays a fundamental role in cellular energy metabolism by catalyzing ADP/ATP exchange across the inner mitochondrial membrane. (NCI)
C37303	Adenine_Nucleotide_Translocator-3	Adenosine_Nucleotide_Transporter	Adenine Nucleotide Translocator-3|ADP-ATP Translocase-3|Liver ADP-ATP Carrier Protein-T2|Liver ADP-ATP Translocator|Mitochondrial Adenine Nucleotide Translocator Solute Carrier Family 25 Member-6|Solute Carrier Family 25 Member-A6	Encoded by human SLC25A6 Gene (Mitochondrial Carrier Family), 298-aa 33-kDa homodimeric integral membrane protein Adenine Nucleotide Translocator-3 contains 3 Solcar repeats and plays a fundamental role in cellular energy metabolism by catalyzing ADP/ATP exchange across the inner mitochondrial membrane. (NCI)
C37304	Multicentric_Papillary_Thyroid_Carcinoma	Papillary_Thyroid_Carcinoma	Multicentric Thyroid Gland Papillary Carcinoma|Multicentric Papillary Thyroid Carcinoma|Multicentric Papillary Thyroid Gland Carcinoma	A papillary carcinoma arising from the thyroid gland from multiple foci. (NCI05)
C37305	Reactive_Lymphocytosis	Lymphocytosis	Reactive Lymphocytosis
C37306	X-Chromosome_Aberration-Related_Renal_Cell_Carcinoma	Retired_Concepts	Renal Cell Carcinoma Associated with X Chromosome Aberrations|X Chromosome Aberration-Related Renal Cell Carcinoma
C37308	Focal_Segmental_Glomerulosclerosis	Nephropathy	Focal Segmental Glomerulosclerosis|FSGS
C37309	Protein_Tyrosine_Phosphatase_Receptor_Type_Epsilon_Isoform-1	Cell_Surface_Receptor	Protein Tyrosine Phosphatase Receptor Type Epsilon Isoform-1|HPTPE|PTPE|PTPRE|Protein Tyrosine Phosphatase Epsilon Isoform 1|Protein Tyrosine Phosphatase Receptor Type E Isoform 1|Protein Tyrosine Phosphatase Receptor Type Epsilon Polypeptide|R-PTP-Epsilon	Encoded by human PTPRE Gene (PTP Family), alternative isoform 700-aa 81-kDa (precursor) Protein Tyrosine Phosphatase Receptor Type Epsilon Isoform 1 is a type I membrane protein receptor-type PTP with a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic PTP catalytic domains. Alternative isoform 642-aa Protein Tyrosine Phosphatase Epsilon Isoform 2, encoded by human PTPRE Gene, is a cytoplasmic nonreceptor-type PTP with a distinct hydrophilic N-terminus and PTP catalytic domains. Studies of the mouse PTPRE homolog suggest a regulatory role for PTPRE in RAS related signal transduction pathways, cytokine-induced SATA signaling, and activation of voltage-gated K+ channels. (NCI)
C37310	Protein_Tyrosine_Phosphatase_Epsilon_Isoform-2	Protein_Tyrosine_Phosphatase	Protein Tyrosine Phosphatase Epsilon Isoform-2|HPTPE|PTPE|PTPRE|Protein Tyrosine Phosphatase E Isoform 2|Protein Tyrosine Phosphatase Epsilon Polypeptide	Encoded by human PTPRE Gene (PTP Family), alternative isoform 642-aa Protein Tyrosine Phosphatase Epsilon Isoform 2 is a cytoplasmic nonreceptor-type PTP with a distinct hydrophilic N-terminus and PTP catalytic domains. Alternative isoform 700-aa 81-kDa (precursor) Protein Tyrosine Phosphatase Receptor Type Epsilon Isoform 1 is a type I membrane protein receptor-type PTP with a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains. Studies of the mouse homolog suggest a regulatory role for PTPRE in RAS related signal transduction pathways, cytokine-induced SATA signaling, and activation of voltage-gated K+ channels. (NCI)
C37311	Protein_Tyrosine_Phosphatase_Receptor_Type-G	Cell_Surface_Receptor	Protein Tyrosine Phosphatase Receptor Type-G|HPTPG|PTPG|PTPRG|Protein Tyrosine Phosphatase Gamma|Protein Tyrosine Phosphatase Receptor Type Gamma Polypeptide|R-PTP-Gamma|RPTPG|Receptor Tyrosine Phosphatase Gamma|Receptor-Type Protein Phosphatase Gamma	Expressed in many tissues (likely developmentally regulated in brain) by human PTPRG Gene (PTP Family), Protein Tyrosine Phosphatase Receptor Type G is a likely type I membrane protein receptor-type PTP with an extracellular region containing an eukaryotic-type CAH domain and a fibronectin type III domain, a single transmembrane region, and two tandem intracytoplasmic catalytic PTP domains. PTPs typically regulate cell growth, differentiation, and mitotic cycle. (NCI)
C37312	Loss_of_Chromosome_11q	Chromosomal_Loss	del(11q)|Loss of Chromosome 11q
C37313	Protein_Tyrosine_Phosphatase_Receptor_Type-J	Cell_Surface_Receptor	Protein Tyrosine Phosphatase Receptor Type-J|CD148|CD148 Antigen|DEP1|Density Enhanced Phosphatase-1|HPTP Eta|PTPRJ|Protein Tyrosine Phosphatase Eta|Protein Tyrosine Phosphatase Receptor Type J Polypeptide|R-PTP-ETA|SCC1|Tyrosine Phosphatase Receptor Type J	Expressed in all hematopoietic lineages by human PTPRJ Gene (PTP Family), 1337-aa 146-kDa (precursor) N- and O-glycosylated type I membrane Protein Tyrosine Phosphatase Receptor Type J is a receptor-type PTP with an extracellular region containing 9 fibronectin type III repeats, a single transmembrane region, and a single intracytoplasmic PTP catalytic domain. PTPRJ negatively regulates TCR signaling, possibly by interfering with phosphorylation of PLCG1 and LAT. PTPRJ also dephosphorylates the PDGF beta receptor, may be involved in UV-induced signal transduction, and may contribute to contact inhibition of cell growth. Defects in PTPRJ are found in cancers of colon, lung, and breast. (NCI)
C37314	Protein_Tyrosine_Phosphatase-PCPTP1	Cell_Surface_Receptor	Protein Tyrosine Phosphatase-PCPTP1|Ch-1PTPase|EC-PTP|NC-PTPCOM1|PCPTP1|PTP-SL|PTPBR7|PTPRR|Protein Tyrosine Phosphatase Cr1PTPase|Protein Tyrosine Phosphatase NC-PTPCOM1|Protein Tyrosine Phosphatase Receptor Type R|Receptor Type Protein Tyrosine Phosphatase R	Alternative alpha, beta, gamma, and delta isoforms of Protein Tyrosine Phosphatase PCPTP1 are expressed in brain, kidney, placenta, small intestine, stomach, uterus, or prostate by human PTPRR Gene (PTP Family). Type I membrane protein receptor-type PTP isoforms alpha and beta possess an extracellular region, a single transmembrane region, and a single intracellular catalytic domain. Cytoplasmic nonreceptor-type PTP isoforms gamma and delta contain 1 PTP domain and locate in the perinuclear area. PTPRR sequesters inactive MAPKs, such as MAPK1, MAPK3, and MAPK14, in the cytoplasm. MAPKs likely bind to a dephosphorylated kinase interacting motif, phosphorylation of which by Protein Kinase A complex releases MAPKs for activation and nuclear translocation. Mouse Ptprr is expressed predominately in the brain and regulates MAP kinase activity and localization. (NCI)
C37315	Protein_Tyrosine_Phosphatase_Receptor_Type-T	Cell_Surface_Receptor	Protein Tyrosine Phosphatase Receptor Type-T|PTPRT|R-PTP-T|RPTP Rho|Receptor Protein Tyrosine Phosphatase|Receptor Type Protein Tyrosine Phosphatase T	Expressed in the central nervous system by human PTPRT Gene (PTP Family), type I membrane Protein Tyrosine Phosphatase Receptor Type T is a receptor-type PTP with an extracellular region containing 4 fibronectin type III domains, 1 Ig-like C2-type domain, and 1 MAM domain; a single transmembrane region; and 2 tandem intracellular PTP catalytic domains. PTPRT may be involved in signal transduction and cellular adhesion in the CNS. PTPs typically regulate cell growth, differentiation, and mitotic cycle. The mouse protein structure and expression also suggest a role in signal transduction and cellular adhesion in the central nervous system. (NCI)
C37316	_Xp22_33	Chromosome_Band	Xp22.33	A chromosome band present on Xp
C37317	Protein_Phosphatase-2A-48kDa_Regulatory_Subunit	Protein_Phosphatase_Regulatory_Protein	Protein Phosphatase-2A-48kDa Regulatory Subunit|B Double Prime|NY-REN-8|NY-REN-8 Antigen|PP2A B Double Prime Subunit PR48|PP2A Subunit B PR48 Isoform|PR48|Serine/Threonine Protein Phosphatase 2A 48kDa Regulatory Subunit|Serine/Threonine Protein Phosphatase 2A 48kDa Regulatory Subunit B	Encoded by human PR48 Gene (PP2A Regulatory Subunit B Family), 414-aa nuclear Protein Phosphatase 2A 48kDa Regulatory Subunit is a B regulatory subunit of PP2A. PR48 specifically interacts with the N-terminal region of and dephosphorylates CDC6, modulating initiation of DNA replication and cell cycle control. A major heterotrimeric Ser/Thr phosphatase implicated in negative control of many cellular processes including cell growth and division, PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A that may differ in substrate specificity, subcellular location, or tissue specific expression. (NCI)
C37318	_101_H_Mouse	Inbred_Mouse	101/H Mouse|101/H
C37319	_101_Rl_Mouse	Inbred_Mouse	101/Rl Mouse|101/Rl
C37320	_129_Sv_Mouse	Inbred_Mouse	129/Sv Mouse|129/Sv
C37321	_129P1_Re_Mouse	Inbred_Mouse	129P1/Re Mouse|129P1/Re
C37322	_129P1_ReJ_Mouse	Inbred_Mouse	129P1/ReJ Mouse|129P1/ReJ
C37323	_129P1_ReJLacFib_Mouse	Inbred_Mouse	129P1/ReJLacFib Mouse|129P1/ReJLacFib
C37324	_129P2_Ola_Mouse	Inbred_Mouse	129P2/Ola Mouse|129P2/Ola
C37325	_129P2_OlaHsd_Mouse	Inbred_Mouse	129P2/OlaHsd Mouse|129P2/OlaHsd
C37326	_129P2_SvOla_Mouse	Inbred_Mouse	129P2/SvOla Mouse|129P2/SvOla
C37327	_129P3_J_Mouse	Inbred_Mouse	129P3/J Mouse|129P3/J
C37328	_129P3_JEmsJ_Mouse	Inbred_Mouse	129P3/JEmsJ Mouse|129P3/JEmsJ
C37329	_129P4_Rr_Mouse	Inbred_Mouse	129P4/Rr Mouse|129P4/Rr
C37330	_129P4_RrJ_Mouse	Inbred_Mouse	129P4/RrJ Mouse|129P4/RrJ
C37331	_129P4_RrRkJ_Mouse	Inbred_Mouse	129P4/RrRkJ Mouse|129P4/RrRkJ
C37332	_129P4_RrSv_Mouse	Inbred_Mouse	129P4/RrSv Mouse|129P4/RrSv
C37333	_129S_Sv_Mouse	Inbred_Mouse	129S/Sv Mouse|129S/Sv
C37334	_129S_SvEv_Mouse	Inbred_Mouse	129S/SvEv Mouse|129S/SvEv
C37335	_129S1_Sv_Mouse	Inbred_Mouse	129S1/Sv Mouse|129S1/Sv
C37336	_129S1_SvImJ_Mouse	Inbred_Mouse	129S1/SvImJ Mouse|129S1/SvImJ
C37337	_129S2_SvPas_Mouse	Inbred_Mouse	129S2/SvPas Mouse|129S2/SvPas
C37338	_129S2_SvPasIco_Mouse	Inbred_Mouse	129S2/SvPasIco Mouse|129S2/SvPasIco
C37339	_129S3_SvImJ_Mouse	Inbred_Mouse	129S3/SvImJ Mouse|129S3/SvImJ
C37340	_129S4_SvJae_Mouse	Inbred_Mouse	129S4/SvJae Mouse|129S4/SvJae
C37341	_129S4_SvJaeSor_Mouse	Inbred_Mouse	129S4/SvJaeSor Mouse|129S4/SvJaeSor
C37342	_129S5_SvEvBrd_Mouse	Inbred_Mouse	129S5/SvEvBrd Mouse|129S5/SvEvBrd
C37343	_129S6_SvEvTac_Mouse	Inbred_Mouse	129S6/SvEvTac Mouse|129S6/SvEvTac
C37344	_129S7_SvEvBrd_Mouse	Inbred_Mouse	129S7/SvEvBrd Mouse|129S7/SvEvBrd
C37345	_129T2_SvEms_Mouse	Inbred_Mouse	129T2/SvEms Mouse|129T2/SvEms
C37346	_129T2_SvEmsJ_Mouse	Inbred_Mouse	129T2/SvEmsJ Mouse|129T2/SvEmsJ
C37347	_129X1_Sv_Mouse	Inbred_Mouse	129X1/Sv Mouse|129X1/Sv
C37348	A_Mouse	Inbred_Mouse	A Mouse|A
C37349	A_HeJ_Mouse	Inbred_Mouse	A/HeJ Mouse|A/HeJ
C37350	A_JOlaHsd_Mouse	Inbred_Mouse	A/JOlaHsd Mouse|A/JOlaHsd
C37351	A_WySnJ_Mouse	Inbred_Mouse	A/WySnJ Mouse|A/WySnJ
C37352	ABP_LeJ_Mouse	Inbred_Mouse	ABP/LeJ Mouse|ABP/LeJ
C37353	AEJ_Gn_Mouse	Inbred_Mouse	AEJ/Gn Mouse|AEJ/Gn
C37354	AKR_Mouse	Inbred_Mouse	AKR Mouse|AKR
C37355	AKR_N_Mouse	Inbred_Mouse	AKR/N Mouse|AKR/N
C37356	ALR_Mouse	Inbred_Mouse	ALR Mouse|ALR
C37357	BALB_c_Mouse	Inbred_Mouse	BALB/c Mouse|BALB/c
C37358	BALB_cAnPt_Mouse	Inbred_Mouse	BALB/cAnPt Mouse|BALB/cAnPt
C37359	BALB_cBy_Mouse	Inbred_Mouse	BALB/cBy Mouse|BALB/cBy
C37360	BALB_cByJ_Mouse	Inbred_Mouse	BALB/cByJ Mouse|BALB/cByJ
C37361	BALB_cCrl_Mouse	Inbred_Mouse	BALB/cCrl Mouse|BALB/cCrl
C37362	BALB_cHeA_Mouse	Inbred_Mouse	BALB/cHeA Mouse|BALB/cHeA
C37363	BALB_cRl_Mouse	Inbred_Mouse	BALB/cRl Mouse|BALB/cRl
C37364	BTBR_Mouse	Inbred_Mouse	BTBR Mouse|BTBR
C37365	BTBRTF_Mouse	Inbred_Mouse	BTBRTF Mouse|BTBRTF
C37366	C3H_Mouse	Inbred_Mouse	C3H Mouse|C3H
C37367	C3H_He_Mouse	Inbred_Mouse	C3H/He Mouse|C3H/He
C37368	C3H_HeH_Mouse	Inbred_Mouse	C3H/HeH Mouse|C3H/HeH
C37369	C3H_HeJ_Mouse	Inbred_Mouse	C3H/HeJ Mouse|C3H/HeJ
C37370	C3H_HeN_Mouse	Inbred_Mouse	C3H/HeN Mouse|C3H/HeN
C37371	C3H_HeOuJ_Mouse	Inbred_Mouse	C3H/HeOuJ Mouse|C3H/HeOuJ
C37372	C3H_HeSnJ_Mouse	Inbred_Mouse	C3H/HeSnJ Mouse|C3H/HeSnJ
C37373	C3H_Rl_Mouse	Inbred_Mouse	C3H/Rl Mouse|C3H/Rl
C37374	C3HeB_FeJ_Mouse	Inbred_Mouse	C3HeB/FeJ Mouse|C3HeB/FeJ
C37375	C57BL_Mouse	Inbred_Mouse	C57BL Mouse|C57BL
C37376	C57BL_10_Mouse	Inbred_Mouse	C57BL/10 Mouse|C57BL/10
C37377	C57BL_10J_Mouse	Inbred_Mouse	C57BL/10J Mouse|C57BL/10J
C37378	C57BL_10ScSnJ_Mouse	Inbred_Mouse	C57BL/10ScSnJ Mouse|C57BL/10ScSnJ
C37379	C57BL_10Sn_Mouse	Inbred_Mouse	C57BL/10Sn Mouse|C57BL/10Sn
C37380	C57BL_10SnJ_Mouse	Inbred_Mouse	C57BL/10SnJ Mouse|C57BL/10SnJ
C37381	C57BL_6By_Mouse	Inbred_Mouse	C57BL/6By Mouse|C57BL/6By
C37382	C57BL_6ByJ_Mouse	Inbred_Mouse	C57BL/6ByJ Mouse|C57BL/6ByJ
C37383	C57BL_6JEiJ_Mouse	Inbred_Mouse	C57BL/6JEiJ Mouse|C57BL/6JEiJ
C37384	C57BL_6JN_Mouse	Inbred_Mouse	C57BL/6JN Mouse|C57BL/6JN
C37385	C57BL_6N_Mouse	Inbred_Mouse	C57BL/6N Mouse|C57BL/6N
C37386	C57BL_6Pas_Mouse	Inbred_Mouse	C57BL/6Pas Mouse|C57BL/6Pas
C37387	C57BL_Ka_Mouse	Inbred_Mouse	C57BL/Ka Mouse|C57BL/Ka
C37388	C57BLKS_J_Mouse	Inbred_Mouse	C57BLKS/J Mouse|C57BLKS/J
C37389	C57BR_Mouse	Inbred_Mouse	C57BR Mouse|C57BR
C37390	C57BR_cdJ_Mouse	Inbred_Mouse	C57BR/cdJ Mouse|C57BR/cdJ
C37391	C57L_Mouse	Inbred_Mouse	C57L Mouse|C57L
C37392	C58_Mouse	Inbred_Mouse	C58 Mouse|C58
C37393	CASA_RkJ_Mouse	Inbred_Mouse	CASA/RkJ Mouse|CASA/RkJ
C37394	CAST_EiJ_Mouse	Inbred_Mouse	CAST/EiJ Mouse|CAST/EiJ
C37395	CBA_Mouse	Inbred_Mouse	CBA Mouse|CBA
C37396	CBA_Ca_Mouse	Inbred_Mouse	CBA/Ca Mouse|CBA/Ca
C37397	CBA_CaH_Mouse	Inbred_Mouse	CBA/CaH Mouse|CBA/CaH
C37398	CBA_CaJ_Mouse	Inbred_Mouse	CBA/CaJ Mouse|CBA/CaJ
C37399	CBA_J_Mouse	Inbred_Mouse	CBA/J Mouse|CBA/J
C37400	CBA_N_Mouse	Inbred_Mouse	CBA/N Mouse|CBA/N
C37401	CZECHII_Mouse	Inbred_Mouse	CZECHII Mouse|CZECHII
C37402	DBA_Mouse	Inbred_Mouse	DBA Mouse|DBA
C37403	DBA_1J_Mouse	Inbred_Mouse	DBA/1J Mouse|DBA/1J
C37404	DBA_1LacJ_Mouse	Inbred_Mouse	DBA/1LacJ Mouse|DBA/1LacJ
C37405	DBA_2N_Mouse	Inbred_Mouse	DBA/2N Mouse|DBA/2N
C37406	FVB_Mouse	Inbred_Mouse	FVB Mouse|FVB
C37407	HRS_J_Mouse	Inbred_Mouse	HRS/J Mouse|HRS/J
C37408	ICR_Mouse	Inbred_Mouse	ICR Mouse|ICR
C37409	LP_J_Mouse	Inbred_Mouse	LP/J Mouse|LP/J
C37410	LT_SvJ_Mouse	Inbred_Mouse	LT/SvJ Mouse|LT/SvJ
C37411	MOLD_RkJ_Mouse	Inbred_Mouse	MOLD/RkJ Mouse|MOLD/RkJ
C37412	MOLF_EiJ_Mouse	Inbred_Mouse	MOLF/EiJ Mouse|MOLF/EiJ
C37413	MRL_MpJ_Mouse	Inbred_Mouse	MRL/MpJ Mouse|MRL/MpJ
C37414	MSM_Ms_Mouse	Inbred_Mouse	MSM/Ms Mouse|MSM/Ms
C37415	NFS_N_Mouse	Inbred_Mouse	NFS/N Mouse|NFS/N
C37416	NMRI_Mouse	Inbred_Mouse	NMRI Mouse|NMRI
C37417	NOD_Mouse	Inbred_Mouse	NOD Mouse|NOD
C37418	NOD_Lt_Mouse	Inbred_Mouse	NOD/Lt Mouse|NOD/Lt
C37419	NOD_LtJ_Mouse	Inbred_Mouse	NOD/LtJ Mouse|NOD/LtJ
C37420	NOR_Mouse	Inbred_Mouse	NOR Mouse|NOR
C37421	NZB_Mouse	Inbred_Mouse	NZB Mouse|NZB
C37422	NZB_BlNJ_Mouse	Inbred_Mouse	NZB/BlNJ Mouse|NZB/BlNJ
C37423	NZC_Mouse	Inbred_Mouse	NZC Mouse|NZC
C37424	NZO_HlLt_Mouse	Inbred_Mouse	NZO/HlLt Mouse|NZO/HlLt
C37425	NZW_Mouse	Inbred_Mouse	NZW Mouse|NZW
C37426	NZW_LacJ_Mouse	Inbred_Mouse	NZW/LacJ Mouse|NZW/LacJ
C37427	O20_A_Mouse	Inbred_Mouse	O20/A Mouse|O20/A
C37428	PERA_EiJ_Mouse	Inbred_Mouse	PERA/EiJ Mouse|PERA/EiJ
C37429	PWK_Mouse	Inbred_Mouse	PWK Mouse|PWK
C37430	RBF_DnJ_Mouse	Inbred_Mouse	RBF/DnJ Mouse|RBF/DnJ
C37431	RIII_Mouse	Inbred_Mouse	RIII Mouse|RIII
C37432	RIII_2J_Mouse	Inbred_Mouse	RIII/2J Mouse|RIII/2J
C37433	RIIIS_J_Mouse	Inbred_Mouse	RIIIS/J Mouse|RIIIS/J
C37434	SEA_GnJ_Mouse	Inbred_Mouse	SEA/GnJ Mouse|SEA/GnJ
C37435	SEG_Mouse	Inbred_Mouse	SEG Mouse|SEG
C37436	SF_CamEiJ_Mouse	Inbred_Mouse	SF/CamEiJ Mouse|SF/CamEiJ
C37437	SJL_Mouse	Inbred_Mouse	SJL Mouse|SJL
C37438	SKIVE_Mouse	Inbred_Mouse	SKIVE Mouse|SKIVE
C37439	SPE_Pas_Mouse	Inbred_Mouse	SPE/Pas Mouse|SPE/Pas
C37440	SPRET_EiJ_Mouse	Inbred_Mouse	SPRET/EiJ Mouse|SPRET/EiJ
C37441	ST_bJ_Mouse	Inbred_Mouse	ST/bJ Mouse|ST/bJ
C37442	STS_A_Mouse	Inbred_Mouse	STS/A Mouse|STS/A
C37443	SWR_Mouse	Inbred_Mouse	SWR Mouse|SWR
C37444	WMP_Mouse	Inbred_Mouse	WMP Mouse|WMP
C37445	YBR_Ki_Mouse	Inbred_Mouse	YBR/Ki Mouse|YBR/Ki
C37446	Iodine_I_131_Tositumomab	I_131_Monoclonal_Antibody_Anti-B1	Iodine I 131 Tositumomab|Bexxar|I 131 Tositumomab|Iodine I-131 Tositumomab|Iodine-131 Tositumomab	A monoclonal antibody directed against a protein (CD20) expressed on the surface of B-lymphocytes and radiolabeled with the radioisotope I 131 with potential antineoplastic activity.  Iodine I 131 tositumomab delivers radiation selectively to neoplastic CD20-expressing B-lymphocytes cells, thereby decreasing the risk of systemic radiotoxicity.
C37447	ABT-510	Angiogenesis_Activator_Inhibitor	ABT-510	A synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1).  ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8). (NCI04)
C37448	Autologous_Heat-Shock_Protein_70_Peptide_Vaccine	Antineoplastic_Vaccine	Autologous Heat-Shock Protein 70 Peptide Vaccine|AG-858	A recombinant cancer vaccine made with tumor-derived heat shock protein 70 (HSP70) peptide complexes.  HSP70 associates with antigenic peptides, transporting them into antigen presenting cells (APC) for processing. Tumor-derived HSP70-peptide complexes used in vaccine preparations have been shown to prime tumor immunity and tumor-specific T cells in animal models. (NCI04)
C37449	Survivin_Antigen	Vaccine_Antigen	Survivin Antigen	A tumor-associated antigen. Overexpressed in many tumors, survivin inhibits tumor cell apoptosis. Vaccination with survivin may result in a cytotoxic T-cell response against survivin antigen-expressing tumor cells, resulting in decreased tumor cell proliferation and tumor cell death.
C37450	NA17-A_Antigen	Tumor_Antigen	NA17-A Antigen|NA17-A	A specific melanoma antigen protein derived from a patient (NA17) with cutaneous melanoma metastases.  The NA-17-A antigen is part of the enzyme N-acetyl glucosaminyl-transferase V (GnT-V). Approximately half of melanomas have been found to express significant levels of this atypical protein, which is not expressed by normal tissues. (NCI04)
C37451	DJ-927	Taxane_Compound	DJ-927	A semi-synthetic orally-available taxane derivative with potent antineoplastic properties.  DJ-927 binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein-related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors.  DJ-927I is more potent than paclitaxel and docetaxel and is the first oral taxane derivative. (NCI04)
C37452	Ixabepilone	Epothilone_B_Analogue	Ixabepilone|(1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione|Azaepothilone B|BMS 247550|BMS-247550|BMS247550|Epothilone-B BMS 247550	A semisynthetic analogue of epothilone B with antineoplastic activity.  Ixabepilone (BMS-247550) binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis. This agent demonstrates antineoplastic activity against taxane-resistant cell lines. (NCI04)
C37453	Efaproxiral	Retired_Concepts	Efaproxiral|RSR13	A synthetic small molecule with radiosensitizing activity.  Efaproxiral increases oxygen levels in hypoxic tumor tissues by binding non-covalently to the hemoglobin tetramer and decreasing hemoglobin-oxygen binding affinity.  Increasing tumor oxygenation reduces tumor radioresistance. (NCI04)
C37454	EL625	Antisense_Agent	EL625|OL(1)p53
C37455	Zebularine	DNA_Methyltransferase_Inhibitor	Zebularine|1-beta-D-Ribofuranosyl-2(1H)-pyrimidinone|2-Pyrimidone-1-beta-D-riboside|Pyrimidin-2-one beta-Ribofuranoside
C37456	Hypericin	Hypericum_Perforatum	Hypericin
C37457	C-C_Chemokine_Receptor_Type_9	Chemokine_Receptor	C-C Chemokine Receptor Type 9|CCR-9|CCR9|Chemokine (C-C Motif) Receptor 9|GPR-9-6	Differentially expressed in T lymphocytes in small intestine and colon as well as in thymus, lymph nodes, and spleen as two variants by human CCR9 Gene (GPCR1/Beta Chemokine Receptor Family), C-C Chemokine Receptor Type 9 is a seven transmembrane G protein-coupled receptor and regulator of thymocyte migration/recruitment and development that may promote specialization of immune responses and inflammation in different regions of the gastrointestinal tract. CCR9 mediates intracellular calcium flux and specifically binds to CC chemokine TECK/CCL25 ligand. (From LocusLink and NCI)
C37458	Ad5CMV-p53-Gene_Docetaxel_Doxorubicin	Chemotherapy_Regimen	Ad5CMV-p53 Gene/Docetaxel/Doxorubicin
C37459	Autologous-Dendritic-Cells_CMV-pp65-Peptide	Chemotherapy_Regimen	Autologous Dendritic Cells/CMV pp65 Peptide
C37460	Autologous-Dendritic-Cells_Keyhole-Limpet-Hemocyanin_MAGE-3_Melan-A_Survivin-Antigen	Chemotherapy_Regimen	Autologous Dendritic Cells/Keyhole Limpet Hemocyanin/MAGE-3/Melan-A/Survivin Antigen
C37461	Autologous-Dendritic-Cells_MAGE-3_Melan-A_Survivin-Antigen	Chemotherapy_Regimen	Autologous Dendritic Cells/MAGE-3/Melan-A/Survivin Antigen
C37462	Autologous-Lymphocytes_gp100-Antigen_Interleukin-12_MAGE-3_Melan-A_NA17-A-Antigen	Chemotherapy_Regimen	Autologous Lymphocytes/gp100 Antigen/Interleukin-12/MAGE-3/Melan-A/NA17-A Antigen
C37463	Autologous-Lymphocytes_gp100-Antigen_Interleukin-2_Interleukin-12_MAGE-3_Melan-A_NA17-A-Antigen	Chemotherapy_Regimen	Autologous Lymphocytes/gp100 Antigen/Interleukin-2/Interleukin-12/MAGE-3/Melan-A/NA17-A Antigen
C37464	Carboplatin_Doxorubicin-Hydrochloride-Liposome	Chemotherapy_Regimen	Carboplatin/Doxorubicin Hydrochloride Liposome
C37465	Carboplatin_Neovastat_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Neovastat/Paclitaxel
C37466	Carboplatin_Paclitaxel_ZD-6474	Chemotherapy_Regimen	Carboplatin/Paclitaxel/ZD-6474
C37467	cBR96-Doxorubicin-Immunoconjugate_Gemcitabine	Chemotherapy_Regimen	cBR96-Doxorubicin Immunoconjugate/Gemcitabine
C37468	Cisplatin_Doxorubicin-Hydrochloride-Liposome_Mitomycin	Chemotherapy_Regimen	Cisplatin/Doxorubicin Hydrochloride Liposome/Mitomycin
C37469	Cisplatin_Doxorubicin-Hydrochloride-Liposome_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Doxorubicin Hydrochloride Liposome/Paclitaxel
C37470	Cisplatin_Doxorubicin_Methotrexate_Pamidronate-Disodium	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Methotrexate/Pamidronate Disodium
C37471	Cisplatin_Geldanamycin-Analogue_Gemcitabine	Chemotherapy_Regimen	Cisplatin/Geldanamycin Analogue/Gemcitabine
C37472	Cisplatin_Neovastat_Vinorelbine	Chemotherapy_Regimen	Cisplatin/Neovastat/Vinorelbine
C37473	Cytarabine_Triapine	Chemotherapy_Regimen	Cytarabine/Triapine
C37474	D1_3-MAGE-3-Fusion-Protein_SB-AS02B-Adjuvant	Chemotherapy_Regimen	D1/3-MAGE-3 Fusion Protein/SB-AS02B Adjuvant
C37475	Docetaxel_Estramustine_Vitaxin-2_Zoledronate	Chemotherapy_Regimen	Docetaxel/Estramustine/Vitaxin-2/Zoledronate
C37476	Docetaxel_Geldanamycin-Analogue	Chemotherapy_Regimen	Docetaxel/Geldanamycin Analogue
C37477	Docetaxel_Vitaxin-2	Chemotherapy_Regimen	Docetaxel/Vitaxin-2
C37478	Flt3-Ligand_gp100-Antigen_Incomplete-Freund_s-Adjuvant_MART-1-Antigen_Tyrosinase	Chemotherapy_Regimen	Flt3 Ligand/gp100 Antigen/Incomplete Freund's Adjuvant/MART-1 Antigen/Tyrosinase|Flt3L/gp100/IFA/MART-1/TYR
C37479	Flu-Matrix_gp100-Antigen_Keyhole-Limpet-Hemocyanin_MAGE-3-MART-1-Antigen_Melan-A_NY-ESO-B_QS21_Tyrosinase-Peptide	Chemotherapy_Regimen	Flu Matrix/gp100 Antigen/Keyhole Limpet Hemocyanin/MAGE-3 /MART-1 Antigen/NY-ESO-B/QS21/Tyrosinase Peptide|Flu Matrix/gp100 Antigen/Keyhole Limpet Hemocyanin/MAGE-3 /MART-1 Antigen/Melan-A/NY-ESO-B/QS21/Tyrosinase Peptide
C37480	Flu-Matrix_gp100-Antigen_Keyhole-Limpet-Hemocyanin_MAGE-3_MART-1-Antigen_Melan-A_NY-ESO-B_Tyrosinase-Peptide	Chemotherapy_Regimen	Flu Matrix/gp100 Antigen/Keyhole Limpet Hemocyanin/MAGE-3/MART-1 Antigen/NY-ESO-B/Tyrosinase Peptide|Flu Matrix/gp100 Antigen/Keyhole Limpet Hemocyanin/MAGE-3/MART-1 Antigen/Melan-A/NY-ESO-B/Tyrosinase Peptide
C37481	Flu-Matrix_gp100-Antigen_MAGE-3_MART-1-Antigen_Melan-A_NY-ESO-B_QS21_Tyrosinase-Peptide	Chemotherapy_Regimen	Flu Matrix/gp100 Antigen/MAGE-3/MART-1 Antigen/NY-ESO-B/QS21/Tyrosinase Peptide|Flu Matrix/gp100 Antigen/MAGE-3/MART-1 Antigen/Melan-A/NY-ESO-B/QS21/Tyrosinase Peptide
C37482	Flu-Matrix_gp100-Antigen_MAGE-3_MART-1-Antigen_Melan-A_NY-ESO-B_Tyrosinase-Peptide	Chemotherapy_Regimen	Flu Matrix/gp100 Antigen/MAGE-3/MART-1 Antigen/NY-ESO-B/Tyrosinase Peptide|Flu Matrix/gp100 Antigen/MAGE-3/MART-1 Antigen/Melan-A/NY-ESO-B/Tyrosinase Peptide
C37483	Fludarabine_Triapine	Chemotherapy_Regimen	Fludarabine/Triapine
C37484	Fluorouracil_Leucovorin-Calcium_Oxaliplatin_PTK787_ZK-222584	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Oxaliplatin/PTK787|Fluorouracil/Leucovorin Calcium/Oxaliplatin/PTK787(ZK 222584)
C37485	Geldanamycin-Analogue_Imatinib-Mesylate	Chemotherapy_Regimen	Geldanamycin Analogue/Imatinib Mesylate|17-AAG/Imatinib Mesylate
C37486	Gemcitabine_Triapine	Chemotherapy_Regimen	Gemcitabine/Triapine
C37487	gp100-Antigen_Incomplete-Freund_s-Adjuvant_Interleukin-12_MART-1-Antigen_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant/Interleukin-12/MART-1 Antigen/Tyrosinase Peptide
C37488	gp100-Antigen_Incomplete-Freund_s-Adjuvant_Interleukin-2_MART-1-Antigen_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant/Interleukin-2/MART-1 Antigen/Tyrosinase Peptide
C37489	gp100-Antigen_Incomplete-Freund_s-Adjuvant_MART-1-Antigen_Sargramostim_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Incomplete Freund's Adjuvant/MART-1 Antigen/Sargramostim/Tyrosinase Peptide
C37490	gp100-Antigen_Melan-A_NA17-A-Antigen_Tyrosinase-Peptide	Chemotherapy_Regimen	gp100 Antigen/Melan-A/NA17-A Antigen/Tyrosinase Peptide
C37491	Interleukin-2_p53-Peptide-Vaccine	Chemotherapy_Regimen	Interleukin-2/p53 Peptide Vaccine
C37493	ABT-510_Carboplatin_Paclitaxel	Chemotherapy_Regimen	ABT-510/Carboplatin/Paclitaxel
C37494	AG-858_Imatinib-Mesylate	Chemotherapy_Regimen	AG-858/Imatinib Mesylate
C37495	ALVAC-CEA-B7-1-Vaccine_Tetanus-Toxoid	Chemotherapy_Regimen	ALVAC-CEA-B7.1 Vaccine/Tetanus Toxoid
C37496	AN-9_Docetaxel	Chemotherapy_Regimen	AN-9/Docetaxel
C37497	BCG_NY-ESO-1-Peptide-Vaccine	Chemotherapy_Regimen	BCG/NY-ESO-1 Peptide Vaccine
C37498	CC-5013_Dexamethasone	Chemotherapy_Regimen	CC-5013/Dexamethasone
C37499	CCI-779_Interferon-Alfa	Chemotherapy_Regimen	CCI-779/Interferon Alfa
C37500	CCI-779_Letrozole	Chemotherapy_Regimen	CCI-779/Letrozole
C37501	CpG-7909_Dacarbazine	Chemotherapy_Regimen	CpG 7909/Dacarbazine
C37502	DHA-Paclitaxel_Gemcitabine	Chemotherapy_Regimen	DHA-Paclitaxel/Gemcitabine
C37503	E7070_Irinotecan	Chemotherapy_Regimen	E7070/Irinotecan
C37504	EP-2101_Montanide-ISA-51	Chemotherapy_Regimen	EP-2101/Montanide ISA-51
C37505	GW572016_Letrozole	Chemotherapy_Regimen	GW572016/Letrozole
C37506	IDEC-114-Monoclonal-Antibody_Rituximab	Chemotherapy_Regimen	IDEC-114 Monoclonal Antibody/Rituximab
C37507	Montanide-ISA-51_NY-ESO-1-Peptide-Vaccine	Chemotherapy_Regimen	Montanide ISA-51/NY-ESO-1 Peptide Vaccine
C37508	Montanide-ISA-51_Multi-Epitope-Melanoma-Peptide-Vaccine_Sargramostim	Chemotherapy_Regimen	Montanide ISA-51/Multi-Epitope Melanoma Peptide Vaccine/Sargramostim
C37509	Montanide-ISA-51_Multi-Epitope-Melanoma-Peptide-Vaccine_Sargramostim_Tetanus-Peptide-Melanoma-Vaccine	Chemotherapy_Regimen	Montanide ISA-51/Multi-Epitope Melanoma Peptide Vaccine/Sargramostim/Tetanus Peptide Melanoma Vaccine
C37512	PEG-Interferon-Alfa-2b_Thalidomide	Chemotherapy_Regimen	PEG-Interferon Alfa-2b/Thalidomide
C37513	Adenovirus-5-Tumor-Necrosis-Factor-Alpha_Capecitabine	Chemotherapy_Regimen	Adenovirus 5-Tumor Necrosis Factor Alpha/Capecitabine
C37514	Adenovirus-L523S-Vaccine_L523S-DNA-Vaccine	Chemotherapy_Regimen	Adenovirus-L523S Vaccine/L523S DNA Vaccine|L523S Vaccine
C37515	Adenovirus_Interleukin-12-Gene	Chemotherapy_Regimen	Adenovirus/Interleukin-12 Gene
C37516	Alemtuzumab_Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Vincristine	Chemotherapy_Regimen	Alemtuzumab/Cyclophosphamide/Doxorubicin/Etoposide/Prednisone/Vincristine
C37517	Alemtuzumab_Fludarabine	Chemotherapy_Regimen	Alemtuzumab/Fludarabine
C37518	Allogeneic-Lymphocytes_MOv-Gamma-Chimeric-Receptor-Gene	Chemotherapy_Regimen	Allogeneic Lymphocytes/MOv-Gamma Chimeric Receptor Gene
C37519	Allogeneic-Lymphocytes_Cyclosporine	Chemotherapy_Regimen	Allogeneic Lymphocytes/Cyclosporine
C37520	Allogeneic-Lymphocytes_Cyclosporine_Sirolimus	Chemotherapy_Regimen	Allogeneic Lymphocytes/Cyclosporine/Sirolimus
C37521	Allogeneic-Lymphocytes_Interleukin-2_MOv-Gamma-Chimeric-Receptor-Gene	Chemotherapy_Regimen	Allogeneic Lymphocytes/Interleukin-2/MOv-Gamma Chimeric Receptor Gene
C37522	Amoxicillin-Clavulanate-Potassium_Ciprofloxacin	Chemotherapy_Regimen	Amoxicillin-Clavulanate Potassium/Ciprofloxacin
C37523	Amsacrine_Azacitidine_Etoposide	Chemotherapy_Regimen	Amsacrine/Azacitidine/Etoposide
C37524	Anastrozole_Celecoxib	Chemotherapy_Regimen	Anastrozole/Celecoxib
C37525	Anastrozole_Fulvestrant	Chemotherapy_Regimen	Anastrozole/Fulvestrant
C37526	Anastrozole_Gefitinib	Chemotherapy_Regimen	Anastrozole/Gefitinib
C37527	Anti-Cytotoxic-T-Lymphocyte-Associated-Antigen-4-Monoclonal-Antibody_Interleukin-2	Chemotherapy_Regimen	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody/Interleukin-2
C37528	Anti-Cytotoxic-T-Lymphocyte-Associated-Antigen-4-Monoclonal-Antibody_Sargramostim	Chemotherapy_Regimen	Anti-Cytotoxic T-Lymphocyte-Associated Antigen-4 Monoclonal Antibody/Sargramostim
C37529	Anti-Thymocyte-Globulin_Busulfan_Cyclophosphamide	Chemotherapy_Regimen	Anti-Thymocyte Globulin/Busulfan/Cyclophosphamide
C37530	Anti-Thymocyte-Globulin_Busulfan_Cyclophosphamide_Methylprednisolone	Chemotherapy_Regimen	Anti-Thymocyte Globulin/Busulfan/Cyclophosphamide/Methylprednisolone
C37531	Anti-Thymocyte-Globulin_Busulfan_Melphalan_Methylprednisolone	Chemotherapy_Regimen	Anti-Thymocyte Globulin/Busulfan/Melphalan/Methylprednisolone
C37532	Anti-Thymocyte-Globulin_Methotrexate_Mycophenolate-Mofetil_Tacrolimus	Chemotherapy_Regimen	Anti-Thymocyte Globulin/Methotrexate/Mycophenolate Mofetil/Tacrolimus
C37533	Arsenic-Trioxide_Imatinib-Mesylate	Chemotherapy_Regimen	Arsenic Trioxide/Imatinib Mesylate
C37534	Asparaginase_Cyclophosphamide_Cytarabine_Methotrexate_Thioguanine_Vincristine	Chemotherapy_Regimen	Asparaginase/Cyclophosphamide/Cytarabine/Methotrexate/Thioguanine/Vincristine
C37535	Asparaginase_Daunorubicin_Methotrexate_Nelarabine_Prednisone_Vincristine	Chemotherapy_Regimen	Asparaginase/Daunorubicin/Methotrexate/Nelarabine/Prednisone/Vincristine
C37536	Autologous-Dendritic-Cells_CD40-Ligand	Chemotherapy_Regimen	Autologous Dendritic Cells/CD40-Ligand
C37537	Autologous-Dendritic-Cells_Carcinoembryonic-Antigen-Peptide-1-6D_CMV-Pp65-Peptide	Chemotherapy_Regimen	Autologous Dendritic Cells/Carcinoembryonic Antigen Peptide 1-6D/CMV Pp65 Peptide
C37538	Autologous-Dendritic-Cells_Fowlpox-CEA-TRICOM-Vaccine	Chemotherapy_Regimen	Autologous Dendritic Cells/Fowlpox-CEA-TRICOM Vaccine
C37539	Autologous-Dendritic-Cells_Indinavir	Chemotherapy_Regimen	Autologous Dendritic Cells/Indinavir
C37540	Autologous-Dendritic-Cells_Tetanus-Toxoid	Chemotherapy_Regimen	Autologous Dendritic Cells/Tetanus Toxoid
C37541	Autologous-Immunoglobulin-Idiotype-KLH-Conjugate-Vaccine_Sargramostim	Chemotherapy_Regimen	Autologous Immunoglobulin Idiotype-KLH Conjugate Vaccine/Sargramostim
C37542	Autologous-Lymphocytes_Fludarabine	Chemotherapy_Regimen	Autologous Lymphocytes/Fludarabine
C37543	Autologous-Lymphocytes_Fluorouracil_Interferon-Alfa_Sargramostim	Chemotherapy_Regimen	Autologous Lymphocytes/Fluorouracil/Interferon Alfa/Sargramostim
C37544	Autologous-Tumor-Cell-Vaccine_CD40-Ligand_Interleukin-2-Gene	Chemotherapy_Regimen	Autologous Tumor Cell Vaccine/CD40-Ligand/Interleukin-2 Gene
C37545	Azacitidine_Carboplatin	Chemotherapy_Regimen	Azacitidine/Carboplatin
C37546	Azacitidine_Cyclophosphamide_Cytarabine_Thioguanine_Vincristine	Chemotherapy_Regimen	Azacitidine/Cyclophosphamide/Cytarabine/Thioguanine/Vincristine
C37547	Azacitidine_Cytarabine_Daunorubicin_Prednisone_Vincristine	Chemotherapy_Regimen	Azacitidine/Cytarabine/Daunorubicin/Prednisone/Vincristine
C37548	Azacitidine_Etoposide	Chemotherapy_Regimen	Azacitidine/Etoposide
C37549	Beclomethasone_Methylprednisolone	Chemotherapy_Regimen	Beclomethasone/Methylprednisolone
C37550	Beclomethasone_Prednisone	Chemotherapy_Regimen	Beclomethasone/Prednisone
C37551	Bevacizumab_PEG-Interferon-Alfa-2b	Chemotherapy_Regimen	Bevacizumab/PEG-Interferon Alfa-2b
C37552	Bevacizumab_Capecitabine_Oxaliplatin	Chemotherapy_Regimen	Bevacizumab/Capecitabine/Oxaliplatin
C37553	Bevacizumab_Cetuximab	Chemotherapy_Regimen	Bevacizumab/Cetuximab
C37554	Bevacizumab_Cetuximab_Irinotecan	Chemotherapy_Regimen	Bevacizumab/Cetuximab/Irinotecan
C37555	Bevacizumab_Cyclophosphamide	Chemotherapy_Regimen	Bevacizumab/Cyclophosphamide
C37556	Bevacizumab_Doxorubicin	Chemotherapy_Regimen	Bevacizumab/Doxorubicin
C37557	Bevacizumab_Erlotinib	Chemotherapy_Regimen	Bevacizumab/Erlotinib
C37558	Bevacizumab_Fluorouracil	Chemotherapy_Regimen	Bevacizumab/Fluorouracil
C37559	Bevacizumab_Imatinib-Mesylate	Chemotherapy_Regimen	Bevacizumab/Imatinib Mesylate
C37560	Bicalutamide_Triptorelin	Chemotherapy_Regimen	Bicalutamide/Triptorelin
C37561	Bleomycin_Cyclophosphamide_Doxorubicin_Methotrexate_Prednisone_Rituximab_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Doxorubicin/Methotrexate/Prednisone/Rituximab/Vincristine
C37562	Bleomycin_Cyclophosphamide_Etoposide_Mitoxantrone_Prednisolone_Rituximab_Vincristine	Chemotherapy_Regimen	Bleomycin/Cyclophosphamide/Etoposide/Mitoxantrone/Prednisolone/Rituximab/Vincristine
C37563	Boronophenylalanine-Fructose-Complex_Sodium-Borocaptate	Chemotherapy_Regimen	Boronophenylalanine-Fructose Complex/Sodium Borocaptate
C37564	Bortezomib_Carboplatin	Chemotherapy_Regimen	Bortezomib/Carboplatin
C37565	Bortezomib_Carboplatin_Etoposide	Chemotherapy_Regimen	Bortezomib/Carboplatin/Etoposide
C37566	Bortezomib_Carboplatin_Gemcitabine	Chemotherapy_Regimen	Bortezomib/Carboplatin/Gemcitabine
C37567	Bortezomib_Carboplatin_Paclitaxel	Chemotherapy_Regimen	Bortezomib/Carboplatin/Paclitaxel
C37568	Bortezomib_Cyclophosphamide_Doxorubicin_Etoposide_Prednisone_Vincristine	Chemotherapy_Regimen	Bortezomib/Cyclophosphamide/Doxorubicin/Etoposide/Prednisone/Vincristine
C37569	Bortezomib_Dexamethasone	Chemotherapy_Regimen	Bortezomib/Dexamethasone
C37570	Bortezomib_Docetaxel	Chemotherapy_Regimen	Bortezomib/Docetaxel
C37571	Bortezomib_Doxorubicin	Chemotherapy_Regimen	Bortezomib/Doxorubicin
C37572	Bortezomib_Fludarabine	Chemotherapy_Regimen	Bortezomib/Fludarabine
C37573	Bortezomib_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Bortezomib/Fluorouracil/Leucovorin Calcium
C37574	Bortezomib_Gemcitabine	Chemotherapy_Regimen	Bortezomib/Gemcitabine
C37575	Bortezomib_Irinotecan	Chemotherapy_Regimen	Bortezomib/Irinotecan
C37576	Bortezomib_Mitoxantrone	Chemotherapy_Regimen	Bortezomib/Mitoxantrone
C37577	Bortezomib_Oxaliplatin	Chemotherapy_Regimen	Bortezomib/Oxaliplatin
C37578	Bortezomib_Paclitaxel	Chemotherapy_Regimen	Bortezomib/Paclitaxel
C37579	Bortezomib_Topotecan	Chemotherapy_Regimen	Bortezomib/Topotecan
C37580	Calcitriol_Zoledronate	Chemotherapy_Regimen	Calcitriol/Zoledronate
C37581	Calcium-Carbonate_Cholecalciferol_Conjugated-Estrogens	Chemotherapy_Regimen	Calcium Carbonate/Cholecalciferol/Conjugated Estrogens
C37582	Calcium-Carbonate_Cholecalciferol_Conjugated-Estrogens_Risedronate	Chemotherapy_Regimen	Calcium Carbonate/Cholecalciferol/Conjugated Estrogens/Risedronate
C37583	Calcium-Carbonate_Cholecalciferol_Risedronate	Chemotherapy_Regimen	Calcium Carbonate/Cholecalciferol/Risedronate
C37584	Capecitabine_DJ-927	Chemotherapy_Regimen	Capecitabine/DJ-927
C37585	Capecitabine_GTI-2040	Chemotherapy_Regimen	Capecitabine/GTI-2040
C37586	Capecitabine_LY317615	Chemotherapy_Regimen	Capecitabine/LY317615
C37587	Capecitabine_Celecoxib_Gefitinib	Chemotherapy_Regimen	Capecitabine/Celecoxib/Gefitinib
C37588	Capecitabine_Celecoxib_Irinotecan	Chemotherapy_Regimen	Capecitabine/Celecoxib/Irinotecan
C37589	Capecitabine_Docetaxel_Tipifarnib	Chemotherapy_Regimen	Capecitabine/Docetaxel/Tipifarnib
C37590	Capecitabine_Fluorouracil_Leucovorin-Calcium_Oxaliplatin	Chemotherapy_Regimen	Capecitabine/Fluorouracil/Leucovorin Calcium/Oxaliplatin
C37591	Capecitabine_Ixabepilone	Chemotherapy_Regimen	Capecitabine/Ixabepilone
C37592	Capecitabine_Tipifarnib	Chemotherapy_Regimen	Capecitabine/Tipifarnib
C37593	Captopril_Tissue-Plasminogen-Activator	Chemotherapy_Regimen	Captopril/Tissue Plasminogen Activator
C37594	Carboplatin_Celecoxib_Gemcitabine	Chemotherapy_Regimen	Carboplatin/Celecoxib/Gemcitabine
C37595	Carboplatin_Celecoxib_Gemcitabine_Zileuton	Chemotherapy_Regimen	Carboplatin/Celecoxib/Gemcitabine/Zileuton
C37596	Carboplatin_Celecoxib_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Celecoxib/Paclitaxel
C37597	Carboplatin_Cetuximab_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Cetuximab/Paclitaxel
C37598	Carboplatin_Cyclophosphamide_Cytarabine_Etoposide-Phosphate_Rituximab_Sodium-Thiosulfate	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Cytarabine/Etoposide Phosphate/Rituximab/Sodium Thiosulfate
C37599	Carboplatin_Cyclophosphamide_Cytarabine_Etoposide_Rituximab_Sodium-Thiosulfate	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Cytarabine/Etoposide/Rituximab/Sodium Thiosulfate
C37600	Carboplatin_Cyclophosphamide_Doxorubicin_Etoposide	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Doxorubicin/Etoposide
C37601	Carboplatin_Cyclophosphamide_Etoposide-Phosphate	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Etoposide Phosphate
C37602	Carboplatin_Cyclophosphamide_Etoposide-Phosphate_Sodium-Thiosulfate	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Etoposide Phosphate/Sodium Thiosulfate
C37603	Carboplatin_Cyclophosphamide_Etoposide_Sodium-Thiosulfate	Chemotherapy_Regimen	Carboplatin/Cyclophosphamide/Etoposide/Sodium Thiosulfate
C37604	Carboplatin_Cytarabine_Etoposide_Ifosfamide_Methotrexate_Rituximab	Chemotherapy_Regimen	Carboplatin/Cytarabine/Etoposide/Ifosfamide/Methotrexate/Rituximab
C37605	Carboplatin_Dexamethasone_Gemcitabine	Chemotherapy_Regimen	Carboplatin/Dexamethasone/Gemcitabine
C37606	Carboplatin_Dexamethasone_Gemcitabine_Rituximab	Chemotherapy_Regimen	Carboplatin/Dexamethasone/Gemcitabine/Rituximab
C37607	Carboplatin_Etoposide_Filgrastim	Chemotherapy_Regimen	Carboplatin/Etoposide/Filgrastim
C37608	Carboplatin_Etoposide_Thalidomide	Chemotherapy_Regimen	Carboplatin/Etoposide/Thalidomide
C37609	Carboplatin_Fludarabine_Thalidomide_Topotecan	Chemotherapy_Regimen	Carboplatin/Fludarabine/Thalidomide/Topotecan
C37610	Carboplatin_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Carboplatin/Fluorouracil/Leucovorin Calcium
C37611	Carboplatin_Gefitinib_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Gefitinib/Paclitaxel
C37612	Carboplatin_Gemcitabine_Zileuton	Chemotherapy_Regimen	Carboplatin/Gemcitabine/Zileuton
C37613	Carboplatin_Irinotecan_Vincristine	Chemotherapy_Regimen	Carboplatin/Irinotecan/Vincristine
C37614	Carboplatin_Ixabepilone	Chemotherapy_Regimen	Carboplatin/Ixabepilone
C37615	Carboplatin_Ixabepilone_Trastuzumab	Chemotherapy_Regimen	Carboplatin/Ixabepilone/Trastuzumab
C37616	Carboplatin_Lobradimil	Chemotherapy_Regimen	Carboplatin/Lobradimil
C37617	Carboplatin_Monoclonal-Antibody-ABX-EGF_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Monoclonal Antibody ABX-EGF/Paclitaxel
C37618	Carboplatin_Oblimersen_Paclitaxel	Chemotherapy_Regimen	Carboplatin/Oblimersen/Paclitaxel
C37619	Carboplatin_Paclitaxel_Prinomastat	Chemotherapy_Regimen	Carboplatin/Paclitaxel/Prinomastat
C37620	Carboplatin_Paclitaxel_Trastuzumab	Chemotherapy_Regimen	Carboplatin/Paclitaxel/Trastuzumab
C37621	Carboplatin_Pemetrexed-Disodium	Chemotherapy_Regimen	Carboplatin/Pemetrexed Disodium
C37622	Carboplatin_Polyglutamate-Paclitaxel	Chemotherapy_Regimen	Carboplatin/Polyglutamate Paclitaxel
C37623	Carcinoembryonic-Antigen-Peptide-1-6D_Montanide-ISA-51	Chemotherapy_Regimen	Carcinoembryonic Antigen Peptide 1-6D/Montanide ISA-51
C37624	Carcinoembryonic-Antigen-Peptide-1-6D_Sargramostim	Chemotherapy_Regimen	Carcinoembryonic Antigen Peptide 1-6D/Sargramostim
C37625	Carmustine_Efaproxiral	Chemotherapy_Regimen	Carmustine/Efaproxiral
C37626	Celecoxib_Cyclophosphamide_Doxorubicin_Etoposide_Ifosfamide_Vinblastine_Vincristine	Chemotherapy_Regimen	Celecoxib/Cyclophosphamide/Doxorubicin/Etoposide/Ifosfamide/Vinblastine/Vincristine
C37627	Celecoxib_Cyclophosphamide_Etoposide_Thalidomide	Chemotherapy_Regimen	Celecoxib/Cyclophosphamide/Etoposide/Thalidomide
C37628	Celecoxib_Docetaxel_Irinotecan	Chemotherapy_Regimen	Celecoxib/Docetaxel/Irinotecan
C37629	Celecoxib_Epirubicin	Chemotherapy_Regimen	Celecoxib/Epirubicin
C37630	Celecoxib_Erlotinib	Chemotherapy_Regimen	Celecoxib/Erlotinib
C37631	Celecoxib_Exemestane	Chemotherapy_Regimen	Celecoxib/Exemestane|Celecoxib + Exemestane
C37632	Celecoxib_Fluorouracil_Irinotecan_Leucovorin-Calcium	Chemotherapy_Regimen	Celecoxib/Fluorouracil/Irinotecan/Leucovorin Calcium
C37633	Celecoxib_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Celecoxib/Fluorouracil/Leucovorin Calcium
C37634	Celecoxib_Fluorouracil_Leucovorin-Calcium_Oxaliplatin	Chemotherapy_Regimen	Celecoxib/Fluorouracil/Leucovorin Calcium/Oxaliplatin
C37635	Celecoxib_Gefitinib	Chemotherapy_Regimen	Celecoxib/Gefitinib|Celecoxib + Gefitinib
C37636	Celecoxib_Gemcitabine	Chemotherapy_Regimen	Celecoxib/Gemcitabine
C37637	Celecoxib_Temozolomide_Thalidomide	Chemotherapy_Regimen	Celecoxib/Temozolomide/Thalidomide
C37638	Celecoxib_Vinorelbine	Chemotherapy_Regimen	Celecoxib/Vinorelbine
C37639	Cetuximab_Cisplatin	Chemotherapy_Regimen	Cetuximab/Cisplatin
C37640	Cetuximab_Docetaxel_Irinotecan	Chemotherapy_Regimen	Cetuximab/Docetaxel/Irinotecan
C37641	Cetuximab_Doxorubicin	Chemotherapy_Regimen	Cetuximab/Doxorubicin|DOX/MOAB C225|Doxorubicin/Monoclonal Antibody C225
C37642	Cetuximab_Fluorouracil_Leucovorin-Calcium_Oxaliplatin	Chemotherapy_Regimen	Cetuximab/Fluorouracil/Leucovorin Calcium/Oxaliplatin
C37643	Cetuximab_Paclitaxel	Chemotherapy_Regimen	Cetuximab/Paclitaxel
C37644	Cisplatin_S-1	Chemotherapy_Regimen	Cisplatin/S-1
C37645	Cisplatin_Cytarabine_Methylprednisolone_Pixantrone	Chemotherapy_Regimen	Cisplatin/Cytarabine/Methylprednisolone/Pixantrone
C37646	Cisplatin_Cytarabine_Methylprednisolone_Pixantrone_Rituximab	Chemotherapy_Regimen	Cisplatin/Cytarabine/Methylprednisolone/Pixantrone/Rituximab
C37647	Cisplatin_Dimesna_Docetaxel	Chemotherapy_Regimen	Cisplatin/Dimesna/Docetaxel
C37648	Cisplatin_Doxorubicin_Methotrexate_Muramyl-Tripeptide-Phosphatidylethanolamine-Liposome	Chemotherapy_Regimen	Cisplatin/Doxorubicin/Methotrexate/Muramyl Tripeptide Phosphatidylethanolamine Liposome
C37649	Cisplatin_Edotecarin	Chemotherapy_Regimen	Cisplatin/Edotecarin
C37650	Cisplatin_Erlotinib_Etoposide	Chemotherapy_Regimen	Cisplatin/Erlotinib/Etoposide
C37651	Cisplatin_Etoposide_Irinotecan	Chemotherapy_Regimen	Cisplatin/Etoposide/Irinotecan
C37652	Cisplatin_Etoposide_Monoclonal-Antibody-11D10-Anti-Idiotype-Vaccine_Monoclonal-Antibody-GD2-Anti-Idiotype-Vaccine	Chemotherapy_Regimen	Cisplatin/Etoposide/Monoclonal Antibody 11D10 Anti-Idiotype Vaccine/Monoclonal Antibody GD2 Anti-Idiotype Vaccine
C37653	Cisplatin_Etoposide_Topotecan	Chemotherapy_Regimen	Cisplatin/Etoposide/Topotecan
C37654	Cisplatin_Filgrastim_Fluorouracil_Paclitaxel	Chemotherapy_Regimen	Cisplatin/Filgrastim/Fluorouracil/Paclitaxel
C37655	Cisplatin_Flavopiridol_Irinotecan	Chemotherapy_Regimen	Cisplatin/Flavopiridol/Irinotecan
C37656	Cisplatin_Fluorouracil_Irinotecan_Leucovorin-Calcium	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Irinotecan/Leucovorin Calcium
C37657	Cisplatin_Fluorouracil_Oblimersen	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Oblimersen
C37658	Cisplatin_Fluorouracil_Paclitaxel_Pegfilgrastim	Chemotherapy_Regimen	Cisplatin/Fluorouracil/Paclitaxel/Pegfilgrastim
C37659	Cisplatin_Gefitinib	Chemotherapy_Regimen	Cisplatin/Gefitinib
C37660	Cisplatin_Gefitinib_Gemcitabine	Chemotherapy_Regimen	Cisplatin/Gefitinib/Gemcitabine
C37661	Cisplatin_Gemcitabine_ISIS-3521	Chemotherapy_Regimen	Cisplatin/Gemcitabine/ISIS 3521
C37662	Cisplatin_Gemcitabine_LY293111	Chemotherapy_Regimen	Cisplatin/Gemcitabine/LY293111
C37663	Cisplatin_Gemcitabine_Tipifarnib	Chemotherapy_Regimen	Cisplatin/Gemcitabine/Tipifarnib
C37664	Cisplatin_Ifosfamide_Muramyl-Tripeptide-Phosphatidylethanolamine-Liposome	Chemotherapy_Regimen	Cisplatin/Ifosfamide/Muramyl Tripeptide Phosphatidylethanolamine Liposome
C37665	Cisplatin_Imatinib-Mesylate_Irinotecan	Chemotherapy_Regimen	Cisplatin/Imatinib Mesylate/Irinotecan
C37666	Cisplatin_Ixabepilone	Chemotherapy_Regimen	Cisplatin/Ixabepilone
C37667	Cisplatin_Pemetrexed-Disodium	Chemotherapy_Regimen	Cisplatin/Pemetrexed Disodium
C37668	Cladribine_Rituximab	Chemotherapy_Regimen	Cladribine/Rituximab
C37669	Clofarabine_Cytarabine	Chemotherapy_Regimen	Clofarabine/Cytarabine
C37670	Clofarabine_Cytarabine_Idarubicin	Chemotherapy_Regimen	Clofarabine/Cytarabine/Idarubicin
C37671	Clofarabine_Idarubicin	Chemotherapy_Regimen	Clofarabine/Idarubicin
C37672	Coenzyme-Q10_Vitamin-E	Chemotherapy_Regimen	Coenzyme Q10/Vitamin E
C37673	Cyclophosphamide_Cyclosporine_Fludarabine_Methylprednisolone_Thiotepa	Chemotherapy_Regimen	Cyclophosphamide/Cyclosporine/Fludarabine/Methylprednisolone/Thiotepa
C37674	Cyclophosphamide_Cytarabine_Daunorubicin_Dexamethasone_Leucovorin-Calcium_Mercaptopurine_Methotrexate_Pegaspargase_Thioguanine_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Daunorubicin/Dexamethasone/Leucovorin Calcium/Mercaptopurine/Methotrexate/Pegaspargase/Thioguanine/Vincristine
C37675	Cyclophosphamide_Cytarabine_Dexamethasone_Etoposide-Phosphate_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Cytarabine/Dexamethasone/Etoposide Phosphate/Methotrexate
C37676	Cyclophosphamide_Dactinomycin_Irinotecan_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Dactinomycin/Irinotecan/Vincristine
C37677	Cyclophosphamide_Decitabine_Doxorubicin	Chemotherapy_Regimen	Cyclophosphamide/Decitabine/Doxorubicin
C37678	Cyclophosphamide_Docetaxel	Retired_Concepts	Cyclophosphamide/Docetaxel
C37679	Cyclophosphamide_Doxorubicin_Epratuzumab_Prednisone_Rituximab_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Epratuzumab/Prednisone/Rituximab/Vincristine
C37680	Cyclophosphamide_Doxorubicin_Etoposide_Fludarabine_Prednisone_Rituximab_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Etoposide/Fludarabine/Prednisone/Rituximab/Vincristine
C37681	Cyclophosphamide_Doxorubicin_Leucovorin-Calcium_Methotrexate_Methylprednisolone_Rituximab_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Leucovorin Calcium/Methotrexate/Methylprednisolone/Rituximab/Vincristine
C37682	Cyclophosphamide_Doxorubicin_Leucovorin-Calcium_Methotrexate_Methylprednisolone_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Leucovorin Calcium/Methotrexate/Methylprednisolone/Vincristine
C37683	Cyclophosphamide_Doxorubicin_Oblimersen_Prednisone_Rituximab_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Oblimersen/Prednisone/Rituximab/Vincristine
C37684	Cyclophosphamide_Doxorubicin_Pegfilgrastim	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Pegfilgrastim
C37685	Cyclophosphamide_Doxorubicin_Prednisolone_Rituximab_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Prednisolone/Rituximab/Vincristine
C37686	Cyclophosphamide_Doxorubicin_Tipifarnib	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Tipifarnib
C37687	Cyclophosphamide_Doxorubicin_Trastuzumab	Chemotherapy_Regimen	Cyclophosphamide/Doxorubicin/Trastuzumab
C37688	Cyclophosphamide_Epirubicin_Trastuzumab	Chemotherapy_Regimen	Cyclophosphamide/Epirubicin/Trastuzumab
C37689	Cyclophosphamide_Etoposide_Imatinib-Mesylate	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Imatinib Mesylate
C37690	Cyclophosphamide_Etoposide_Imatinib-Mesylate_Leucovorin-Calcium_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Imatinib Mesylate/Leucovorin Calcium/Methotrexate
C37691	Cyclophosphamide_Etoposide_Iodine-I-131-Tositumomab	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Iodine I 131 Tositumomab
C37692	Cyclophosphamide_Etoposide_Leucovorin-Calcium_Methotrexate	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Leucovorin Calcium/Methotrexate
C37693	Cyclophosphamide_Etoposide_Prednisone	Chemotherapy_Regimen	Cyclophosphamide/Etoposide/Prednisone
C37694	Cyclophosphamide_Filgrastim_Rituximab	Chemotherapy_Regimen	Cyclophosphamide/Filgrastim/Rituximab
C37695	Cyclophosphamide_Fludarabine_Melphalan	Chemotherapy_Regimen	Cyclophosphamide/Fludarabine/Melphalan
C37696	Cyclophosphamide_Fludarabine_Rituximab	Chemotherapy_Regimen	Cyclophosphamide/Fludarabine/Rituximab
C37697	Cyclophosphamide_Methylprednisolone_Rasburicase_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Methylprednisolone/Rasburicase/Vincristine
C37698	Cyclophosphamide_Methylprednisolone_Rituximab	Chemotherapy_Regimen	Cyclophosphamide/Methylprednisolone/Rituximab
C37699	Cyclophosphamide_Oblimersen	Chemotherapy_Regimen	Cyclophosphamide/Oblimersen
C37700	Cyclophosphamide_Prednisone_Rasburicase_Vincristine	Chemotherapy_Regimen	Cyclophosphamide/Prednisone/Rasburicase/Vincristine
C37701	Cyclophosphamide_Prednisone_Rituximab	Chemotherapy_Regimen	Cyclophosphamide/Prednisone/Rituximab
C37702	Cyclosporine_Sirolimus	Chemotherapy_Regimen	Cyclosporine/Sirolimus
C37703	Cyproterone_Leuprolide	Chemotherapy_Regimen	Cyproterone/Leuprolide
C37704	Cyproterone_Triptorelin	Chemotherapy_Regimen	Cyproterone/Triptorelin
C37705	Cytarabine_EL625_Idarubicin	Chemotherapy_Regimen	Cytarabine/EL625/Idarubicin
C37706	Cytarabine_GTI-2040	Chemotherapy_Regimen	Cytarabine/GTI-2040
C37707	Cytarabine_VNP40101M	Chemotherapy_Regimen	Cytarabine/VNP40101M
C37708	Cytarabine_Daunorubicin_Dexamethasone_Methotrexate_Pegaspargase_Vincristine	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Dexamethasone/Methotrexate/Pegaspargase/Vincristine
C37709	Cytarabine_Daunorubicin_Etoposide_Gemtuzumab-Ozogamicin	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Etoposide/Gemtuzumab Ozogamicin
C37710	Cytarabine_Daunorubicin_Methotrexate_Pegaspargase_Prednisone_Vincristine	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Methotrexate/Pegaspargase/Prednisone/Vincristine
C37711	Cytarabine_Daunorubicin_Zosuquidar-Trihydrochloride	Chemotherapy_Regimen	Cytarabine/Daunorubicin/Zosuquidar Trihydrochloride
C37712	Cytarabine_Dexamethasone_Lomustine_Methotrexate_Procarbazine	Chemotherapy_Regimen	Cytarabine/Dexamethasone/Lomustine/Methotrexate/Procarbazine
C37713	Cytarabine_Etoposide_Gemtuzumab-Ozogamicin_Idarubicin	Chemotherapy_Regimen	Cytarabine/Etoposide/Gemtuzumab Ozogamicin/Idarubicin
C37714	Cytarabine_Etoposide_Methotrexate_Rituximab	Chemotherapy_Regimen	Cytarabine/Etoposide/Methotrexate/Rituximab
C37715	Cytarabine_Flavopiridol_Mitoxantrone	Chemotherapy_Regimen	Cytarabine/Flavopiridol/Mitoxantrone
C37716	Cytarabine_Gemtuzumab-Ozogamicin_Idarubicin	Chemotherapy_Regimen	Cytarabine/Gemtuzumab Ozogamicin/Idarubicin
C37717	Cytarabine_Irinotecan	Chemotherapy_Regimen	Cytarabine/Irinotecan
C37718	Cytarabine_Leucovorin-Calcium_Methotrexate	Chemotherapy_Regimen	Cytarabine/Leucovorin Calcium/Methotrexate
C37719	Cytarabine_Oblimersen	Chemotherapy_Regimen	Cytarabine/Oblimersen
C37720	Cytochlor_Tetrahydrouridine	Chemotherapy_Regimen	Cytochlor/Tetrahydrouridine
C37721	Dacarbazine_Interleukin-2_Temozolomide	Chemotherapy_Regimen	Dacarbazine/Interleukin-2/Temozolomide
C37722	Dacarbazine_Monoclonal-Antibody-Anti-Anb3-Integrin	Chemotherapy_Regimen	Dacarbazine/Monoclonal Antibody Anti-Avb3 Integrin
C37723	Dacarbazine_Temozolomide	Chemotherapy_Regimen	Dacarbazine/Temozolomide
C37724	Daclizumab_Interleukin-2	Chemotherapy_Regimen	Daclizumab/Interleukin-2
C37725	Daclizumab_Methylprednisolone	Chemotherapy_Regimen	Daclizumab/Methylprednisolone
C37726	Daunorubicin_Dexamethasone_Pegaspargase_Vincristine	Chemotherapy_Regimen	Daunorubicin/Dexamethasone/Pegaspargase/Vincristine
C37727	Decitabine_Imatinib-Mesylate	Chemotherapy_Regimen	Decitabine/Imatinib Mesylate
C37728	Decitabine_Valproic-Acid	Chemotherapy_Regimen	Decitabine/Valproic Acid
C37729	Dexamethasone_Doxorubicin_Thalidomide_Vincristine	Chemotherapy_Regimen	Dexamethasone/Doxorubicin/Thalidomide/Vincristine
C37730	Dexamethasone_Epoetin-Alfa	Chemotherapy_Regimen	Dexamethasone/Epoetin Alfa
C37731	Dexamethasone_Fludarabine_Pixantrone_Rituximab	Chemotherapy_Regimen	Dexamethasone/Fludarabine/Pixantrone/Rituximab
C37732	Dexamethasone_Idarubicin_Imatinib-Mesylate_Pegaspargase_Vincristine	Chemotherapy_Regimen	Dexamethasone/Idarubicin/Imatinib Mesylate/Pegaspargase/Vincristine
C37733	Dexamethasone_Idarubicin_Pegaspargase_Vincristine	Chemotherapy_Regimen	Dexamethasone/Idarubicin/Pegaspargase/Vincristine
C37734	Dexamethasone_Oblimersen_Thalidomide	Chemotherapy_Regimen	Dexamethasone/Oblimersen/Thalidomide
C37735	Docetaxel_DN-101	Chemotherapy_Regimen	Docetaxel/DN-101
C37736	Docetaxel_GTI-2040	Chemotherapy_Regimen	Docetaxel/GTI-2040
C37737	Docetaxel_TLK286	Chemotherapy_Regimen	Docetaxel/TLK286
C37738	Docetaxel_ZD6474	Chemotherapy_Regimen	Docetaxel/ZD6474
C37739	Docetaxel_Doxorubicin_Oblimersen	Chemotherapy_Regimen	Docetaxel/Doxorubicin/Oblimersen
C37740	Docetaxel_Epirubicin_Pegfilgrastim	Chemotherapy_Regimen	Docetaxel/Epirubicin/Pegfilgrastim
C37741	Docetaxel_Erlotinib	Chemotherapy_Regimen	Docetaxel/Erlotinib
C37742	Docetaxel_Estramustine_Exisulind	Chemotherapy_Regimen	Docetaxel/Estramustine/Exisulind
C37743	Docetaxel_Fowlpox-PSA-Vaccine	Chemotherapy_Regimen	Docetaxel/Fowlpox-PSA Vaccine
C37744	Docetaxel_Fowlpox-PSA-Vaccine_Sargramostim	Chemotherapy_Regimen	Docetaxel/Fowlpox-PSA Vaccine/Sargramostim
C37745	Docetaxel_Gefitinib	Chemotherapy_Regimen	Docetaxel/Gefitinib
C37746	Docetaxel_Leuprolide_Testosterone	Chemotherapy_Regimen	Docetaxel/Leuprolide/Testosterone
C37747	Docetaxel_Suramin	Chemotherapy_Regimen	Docetaxel/Suramin
C37748	Docetaxel_Tariquidar	Chemotherapy_Regimen	Docetaxel/Tariquidar
C37749	Doxorubicin_Etoposide_Mitotane_Tariquidar_Vincristine	Chemotherapy_Regimen	Doxorubicin/Etoposide/Mitotane/Tariquidar/Vincristine
C37750	Doxorubicin_Ifosfamide_Methotrexate_Muramyl-Tripeptide-Phosphatidylethanolamine-Liposome	Chemotherapy_Regimen	Doxorubicin/Ifosfamide/Methotrexate/Muramyl Tripeptide Phosphatidylethanolamine Liposome
C37751	Doxorubicin_Imatinib-Mesylate_Pegaspargase_Prednisone_Vincristine	Chemotherapy_Regimen	Doxorubicin/Imatinib Mesylate/Pegaspargase/Prednisone/Vincristine
C37752	Doxorubicin_Mercaptopurine_Methotrexate_Prednisone_Vinblastine	Chemotherapy_Regimen	Doxorubicin/Mercaptopurine/Methotrexate/Prednisone/Vinblastine
C37753	Doxorubicin_Oblimersen	Chemotherapy_Regimen	Doxorubicin/Oblimersen
C37754	Doxorubicin_Ranpirnase	Chemotherapy_Regimen	Doxorubicin/Ranpirnase
C37755	Edrecolomab_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Edrecolomab/Fluorouracil/Leucovorin Calcium
C37756	Edrecolomab_Fluorouracil_Levamisole	Chemotherapy_Regimen	Edrecolomab/Fluorouracil/Levamisole
C37757	Edrecolomab_Sargramostim	Chemotherapy_Regimen	Edrecolomab/Sargramostim
C37758	Eniluracil_Fluorouracil	Chemotherapy_Regimen	Eniluracil/Fluorouracil
C37759	Eniluracil_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Eniluracil/Fluorouracil/Leucovorin Calcium
C37760	Epirubicin_Rituximab	Chemotherapy_Regimen	Epirubicin/Rituximab
C37761	Epirubicin_Thalidomide	Chemotherapy_Regimen	Epirubicin/Thalidomide
C37762	Epoetin-Alfa_Thalidomide	Chemotherapy_Regimen	Epoetin Alfa/Thalidomide
C37763	Epratuzumab_Rituximab	Chemotherapy_Regimen	Epratuzumab/Rituximab
C37764	Erlotinib_Fluorouracil_Leucovorin-Calcium_Oxaliplatin	Chemotherapy_Regimen	Erlotinib/Fluorouracil/Leucovorin Calcium/Oxaliplatin
C37765	Erlotinib_Irinotecan	Chemotherapy_Regimen	Erlotinib/Irinotecan
C37766	Erlotinib_Paclitaxel_Trastuzumab	Chemotherapy_Regimen	Erlotinib/Paclitaxel/Trastuzumab
C37767	Erlotinib_Temozolomide	Chemotherapy_Regimen	Erlotinib/Temozolomide
C37768	Estradiol_Zoledronate	Chemotherapy_Regimen	Estradiol/Zoledronate
C37769	Estramustine_Ixabepilone	Chemotherapy_Regimen	Estramustine/Ixabepilone
C37770	Etoposide_Monoclonal-Antibody-3F8	Chemotherapy_Regimen	Etoposide/Monoclonal Antibody 3F8
C37771	Etoposide_Satraplatin	Chemotherapy_Regimen	Etoposide/Satraplatin
C37772	Exemestane_Trastuzumab	Chemotherapy_Regimen	Exemestane/Trastuzumab
C37773	Exemestane_Triptorelin	Chemotherapy_Regimen	Exemestane/Triptorelin
C37774	Filgrastim_Monoclonal-Antibody-Hu1D10	Chemotherapy_Regimen	Filgrastim/Monoclonal Antibody Hu1D10
C37775	Flavopiridol_Fludarabine_Rituximab	Chemotherapy_Regimen	Flavopiridol/Fludarabine/Rituximab
C37776	Flavopiridol_Fluorouracil_Irinotecan_Leucovorin-Calcium	Chemotherapy_Regimen	Flavopiridol/Fluorouracil/Irinotecan/Leucovorin Calcium
C37777	Flavopiridol_Fluorouracil_Leucovorin-Calcium	Chemotherapy_Regimen	Flavopiridol/Fluorouracil/Leucovorin Calcium
C37778	Flavopiridol_Imatinib-Mesylate	Chemotherapy_Regimen	Flavopiridol/Imatinib Mesylate
C37779	Floxuridine_Irinotecan	Chemotherapy_Regimen	Floxuridine/Irinotecan
C37780	Fluorouracil_Virulizin	Chemotherapy_Regimen	Fluorouracil/Virulizin
C37781	Fluorouracil_Gefitinib_Irinotecan_Leucovorin-Calcium	Chemotherapy_Regimen	Fluorouracil/Gefitinib/Irinotecan/Leucovorin Calcium
C37782	Fluorouracil_Gefitinib_Leucovorin-Calcium_Oxaliplatin	Chemotherapy_Regimen	Fluorouracil/Gefitinib/Leucovorin Calcium/Oxaliplatin
C37783	Fluorouracil_Irinotecan_Leucovorin-Calcium_Monoclonal-Antibody-ABX-EGF	Chemotherapy_Regimen	Fluorouracil/Irinotecan/Leucovorin Calcium/Monoclonal Antibody ABX-EGF
C37784	Fluorouracil_Leucovorin-Calcium_UCN-01	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/UCN-01
C37785	Fluorouracil_Leucovorin-Calcium_Lonafarnib	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Lonafarnib
C37786	Fluorouracil_Leucovorin-Calcium_Oblimersen_Oxaliplatin	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Oblimersen/Oxaliplatin
C37787	Fluorouracil_Leucovorin-Calcium_Oxaliplatin_ZD6126	Chemotherapy_Regimen	Fluorouracil/Leucovorin Calcium/Oxaliplatin/ZD6126
C37788	Fowlpox-CEA-TRICOM-Vaccine_Fowlpox-Sargramostim-Vaccine	Chemotherapy_Regimen	Fowlpox-CEA-TRICOM Vaccine/Fowlpox-Sargramostim Vaccine
C37789	Fowlpox-PSA-Vaccine_Sargramostim	Chemotherapy_Regimen	Fowlpox-PSA Vaccine/Sargramostim
C37790	Fowlpox-PSA-TRICOM-Vaccine_Fowlpox-Sargramostim-Vaccine_Vaccinia-Prostate-Specific-Antigen-TRICOM-Vaccine	Chemotherapy_Regimen	Fowlpox-PSA-TRICOM Vaccine/Fowlpox-Sargramostim Vaccine/Vaccinia-Prostate-Specific Antigen-TRICOM Vaccine
C37791	Fowlpox-PSA-TRICOM-Vaccine_Sargramostim_Vaccinia-Prostate-Specific-Antigen-TRICOM-Vaccine	Chemotherapy_Regimen	Fowlpox-PSA-TRICOM Vaccine/Sargramostim/Vaccinia-Prostate-Specific Antigen-TRICOM Vaccine
C37792	Fowlpox-PSA-TRICOM-Vaccine_Vaccinia-Prostate-Specific-Antigen-TRICOM-Vaccine	Chemotherapy_Regimen	Fowlpox-PSA-TRICOM Vaccine/Vaccinia-Prostate-Specific Antigen-TRICOM Vaccine
C37793	Fowlpox-Sargramostim-Vaccine_Fowlpox-TRICOM-Vaccine	Chemotherapy_Regimen	Fowlpox-Sargramostim Vaccine/Fowlpox-TRICOM Vaccine
C37794	Fowlpox-Tyrosinase-Vaccine_Interleukin-2_Vaccinia-Tyrosinase-Vaccine	Chemotherapy_Regimen	Fowlpox-Tyrosinase Vaccine/Interleukin-2/Vaccinia-Tyrosinase Vaccine
C37795	Fulvestrant_Gefitinib	Chemotherapy_Regimen	Fulvestrant/Gefitinib
C37796	Gefitinib_Oxaliplatin	Chemotherapy_Regimen	Gefitinib/Oxaliplatin
C37797	Gefitinib_Tamoxifen	Chemotherapy_Regimen	Gefitinib/Tamoxifen
C37798	Gefitinib_Temozolomide	Chemotherapy_Regimen	Gefitinib/Temozolomide
C37799	Gefitinib_Trastuzumab	Chemotherapy_Regimen	Gefitinib/Trastuzumab
C37800	Gemcitabine_Virulizin	Chemotherapy_Regimen	Gemcitabine/Virulizin
C37801	Gemcitabine_Ixabepilone	Chemotherapy_Regimen	Gemcitabine/Ixabepilone
C37802	Gemcitabine_Lonafarnib	Chemotherapy_Regimen	Gemcitabine/Lonafarnib
C37803	Gemcitabine_Mistletoe	Chemotherapy_Regimen	Gemcitabine/Mistletoe
C37804	Gemcitabine_Oblimersen	Chemotherapy_Regimen	Gemcitabine/Oblimersen
C37805	Gemcitabine_Soblidotin	Chemotherapy_Regimen	Gemcitabine/Soblidotin
C37806	Gemcitabine_Suramin	Chemotherapy_Regimen	Gemcitabine/Suramin
C37807	Gemcitabine_Tipifarnib	Chemotherapy_Regimen	Gemcitabine/Tipifarnib
C37808	Gemcitabine_Trastuzumab	Chemotherapy_Regimen	Gemcitabine/Trastuzumab|Trasbuzumab/Gemcitabine|Trastuzumab/Gemcitabine
C37809	Gusperimus_Monoclonal-Antibody-L6	Chemotherapy_Regimen	Gusperimus/Monoclonal Antibody L6
C37810	Imatinib-Mesylate_PEG-Interferon-Alfa-2a	Chemotherapy_Regimen	Imatinib Mesylate/PEG-Interferon Alfa-2a
C37811	Imatinib-Mesylate_Oblimersen	Chemotherapy_Regimen	Imatinib Mesylate/Oblimersen
C37812	Incomplete-Freund_s-Adjuvant_MART-1-Antigen	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/MART-1 Antigen|IFA/MART-1|Incomplete Freund's Adjuvant/MART-1
C37813	Incomplete-Freund_s-Adjuvant_Interleukin-12_Tyrosinase-Related-Protein-1	Retired_Concepts	Incomplete Freund's Adjuvant/Interleukin-12/Tyrosinase-Related Protein-1
C37814	Incomplete-Freund_s-Adjuvant_Interleukin-2_Tyrosinase-Related-Protein-1	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/Interleukin-2/Tyrosinase-Related Protein-1
C37815	Incomplete-Freund_s-Adjuvant_Peptide-946-Melanoma-Vaccine_Tetanus-Peptide-Melanoma-Vaccine	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/Peptide 946 Melanoma Vaccine/Tetanus Peptide Melanoma Vaccine
C37816	Incomplete-Freund_s-Adjuvant_Sargramostim_Tyrosinase-Related-Protein-1	Chemotherapy_Regimen	Incomplete Freund's Adjuvant/Sargramostim/Tyrosinase-Related Protein-1
C37817	Interferon-Alfa_Oblimersen	Chemotherapy_Regimen	Interferon Alfa/Oblimersen
C37818	Interferon-Gamma_Voriconazole	Chemotherapy_Regimen	Interferon Gamma/Voriconazole
C37819	Interleukin-12_Montanide_ISA-51_Tyrosinase-Related_Protein-1	Chemotherapy_Regimen	Interleukin-12/Montanide ISA-51/Tyrosinase-Related Protein-1
C37820	Interleukin-12_Paclitaxel	Chemotherapy_Regimen	Interleukin-12/Paclitaxel
C37821	Irinotecan_Pemetrexed-Disodium	Chemotherapy_Regimen	Irinotecan/Pemetrexed Disodium
C37822	Letrozole_Tipifarnib	Chemotherapy_Regimen	Letrozole/Tipifarnib
C37823	Leucovorin-Calcium_Mercaptopurine_Methotrexate_Vincristine	Chemotherapy_Regimen	Leucovorin Calcium/Mercaptopurine/Methotrexate/Vincristine
C37824	Lomustine_Temozolomide_Thalidomide	Chemotherapy_Regimen	Lomustine/Temozolomide/Thalidomide
C37825	Lonafarnib_Paclitaxel_Trastuzumab	Chemotherapy_Regimen	Lonafarnib/Paclitaxel/Trastuzumab
C37826	Marijuana_Morphine	Chemotherapy_Regimen	Marijuana/Morphine
C37827	Melanoma-Helper-Peptide-Vaccine_Montanide-ISA-51_Multi-Epitope-Melanoma-Peptide-Vaccine_Sargramostim	Chemotherapy_Regimen	Melanoma Helper Peptide Vaccine/Montanide ISA-51/Multi-Epitope Melanoma Peptide Vaccine/Sargramostim
C37828	Melanoma-Helper-Peptide-Vaccine_Montanide-ISA-51_Sargramostim	Chemotherapy_Regimen	Melanoma Helper Peptide Vaccine/Montanide ISA-51/Sargramostim
C37829	Mercaptopurine_Methotrexate_Nelarabine	Chemotherapy_Regimen	Mercaptopurine/Methotrexate/Nelarabine
C37830	Methotrexate_Mycophenolate-Mofetil_Tacrolimus	Chemotherapy_Regimen	Methotrexate/Mycophenolate Mofetil/Tacrolimus
C37831	Methotrexate_Procarbazine_Rituximab_Vincristine	Chemotherapy_Regimen	Methotrexate/Procarbazine/Rituximab/Vincristine
C37832	Methotrexate_Rituximab_Temozolomide	Chemotherapy_Regimen	Methotrexate/Rituximab/Temozolomide
C37833	Methotrexate_Thiotepa	Chemotherapy_Regimen	Methotrexate/Thiotepa
C37834	Methylprednisolone_Mycophenolate-Mofetil_Tacrolimus	Chemotherapy_Regimen	Methylprednisolone/Mycophenolate Mofetil/Tacrolimus
C37835	Mitoxantrone_Prednisone_YM598	Chemotherapy_Regimen	Mitoxantrone/Prednisone/YM598
C37836	Mitoxantrone_Prednisone_Prinomastat	Chemotherapy_Regimen	Mitoxantrone/Prednisone/Prinomastat
C37837	Monoclonal-Antibody-11D10-Anti-Idiotype-Vaccine_Monoclonal-Antibody-GD2-Anti-Idiotype-Vaccine	Chemotherapy_Regimen	Monoclonal Antibody 11D10 Anti-Idiotype Vaccine/Monoclonal Antibody GD2 Anti-Idiotype Vaccine
C37838	Multivitamins_Soy-Protein-Isolate	Chemotherapy_Regimen	Multivitamins/Soy Protein Isolate
C37839	Nilutamide_Triptorelin	Chemotherapy_Regimen	Nilutamide/Triptorelin
C37840	Nolatrexed-Dihydrochloride_Cisplatin	Chemotherapy_Regimen	Nolatrexed Dihydrochloride/Cisplatin
C37841	Oblimersen_Rituximab	Chemotherapy_Regimen	Oblimersen/Rituximab
C37842	Paclitaxel_Pegfilgrastim	Chemotherapy_Regimen	Paclitaxel/Pegfilgrastim
C37843	Paclitaxel_Suramin	Chemotherapy_Regimen	Paclitaxel/Suramin
C37844	Paclitaxel_Trastuzumab	Chemotherapy_Regimen	Paclitaxel/Trastuzumab
C37845	Patent-Blue-V-Dye_Technetium-Tc-99m-Sulfur-Colloid	Chemotherapy_Regimen	Patent Blue V Dye/Technetium Tc 99m Sulfur Colloid
C37846	Pixantrone_Rituximab	Chemotherapy_Regimen	Pixantrone/Rituximab
C37847	Prednisone_UCN-01	Chemotherapy_Regimen	Prednisone/UCN-01
C37848	Prednisone_Satraplatin	Chemotherapy_Regimen	Prednisone/Satraplatin
C37849	Rv-B7-1-Vaccine_Sargramostim_Vaccinia-Prostate-Specific-Antigen-Vaccine	Chemotherapy_Regimen	Rv-B7.1 Vaccine/Sargramostim/Vaccinia-Prostate-Specific Antigen Vaccine
C37850	Ranpirnase_Tamoxifen	Chemotherapy_Regimen	Ranpirnase/Tamoxifen
C37851	Rifampin_Tetracycline	Chemotherapy_Regimen	Rifampin/Tetracycline
C37852	Sargramostim_Telomerase_540-548-Peptide-Vaccine	Chemotherapy_Regimen	Sargramostim/Telomerase: 540-548 Peptide Vaccine
C37853	Sargramostim_Vaccinia-CEA-TRICOM-Vaccine	Chemotherapy_Regimen	Sargramostim/Vaccinia-CEA-TRICOM Vaccine
C37854	Sargramostim_Vaccinia-MUC-1-Vaccine_Vaccinia-TRICOM-Vaccine	Chemotherapy_Regimen	Sargramostim/Vaccinia-MUC-1 Vaccine/Vaccinia-TRICOM Vaccine
C37855	Selenium_Soy-Protein-Isolate_Vitamin-E	Chemotherapy_Regimen	Selenium/Soy Protein Isolate/Vitamin E
C37856	Sulindac_Tamoxifen	Chemotherapy_Regimen	Sulindac/Tamoxifen
C37857	Tamoxifen_Tipifarnib	Chemotherapy_Regimen	Tamoxifen/Tipifarnib
C37858	Tamoxifen_Triptorelin	Chemotherapy_Regimen	Tamoxifen/Triptorelin
C37859	Tipifarnib_Topotecan	Chemotherapy_Regimen	Tipifarnib/Topotecan
C37860	Tipifarnib_Trastuzumab	Chemotherapy_Regimen	Tipifarnib/Trastuzumab
C37861	Topotecan_UCN-01	Chemotherapy_Regimen	Topotecan/UCN-01
C37862	Vaccinia-MUC-1-Vaccine_Vaccinia-TRICOM-Vaccine	Chemotherapy_Regimen	Vaccinia-MUC-1 Vaccine/Vaccinia-TRICOM Vaccine
C37863	Vinorelbine_Zosuquidar-Trihydrochloride	Chemotherapy_Regimen	Vinorelbine/Zosuquidar Trihydrochloride
C37864	Autoimmune_Lymphoproliferative_Syndrome	Syndrome	Autoimmune Lymphoproliferative Syndrome|ALPS|Canale-Smith Syndrome
C37865	Trisomy_17	Trisomy	Trisomy 17
C37866	Trisomy_16	Trisomy	Trisomy 16
C37867	Tetrasomy_7	Tetrasomy	Tetrasomy 7
C37868	Tetrasomy_17	Tetrasomy	Tetrasomy 17
C37869	Gray_Zone_Lymphoma	Lymphoma	Gray Zone Lymphoma	A group of lymphomas displaying molecular, morphologic, immunophenotypic, and clinical overlap between Hodgkin's and non-Hodgkin's lymphoma.  This term particularly applies to mediastinal lymphomas with overlapping features of mediastinal (thymic) large B-cell lymphoma and classical Hodgkin's lymphoma. -- 2004
C37870	Mediastinal_Gray_Zone_Lymphoma	Gray_Zone_Lymphoma|Mediastinal_Lymphoma	Mediastinal Gray Zone Lymphoma	A mediastinal lymphoma with molecular, morphologic, immunophenotypic, and clinical features of both mediastinal (thymic) large B-cell lymphoma and nodular sclerosis classical Hodgkin's lymphoma.  The identification of this group of lymphomas, along with recent gene expression profiling results (PDL2 gene expression in both mediastinal (thymic) large B-cell lymphoma tissues and Hodgkin's lymphoma cell lines), further supports the hypothesis that mediastinal (thymic) large B-cell lymphomas and classical Hodgkin's lymphomas are related entities. -- 2004
C37871	Pityriasis_Lichenoides_et_Varioliformis_Acuta	Non-Neoplastic_Skin_Disorder	Pityriasis Lichenoides et Varioliformis Acuta|PLEVA
C37872	Renal_Cell_Carcinoma_with_t_X_1_p11_q21	Xp11_Translocation-Related_Renal_Cell_Carcinoma	Renal Cell Carcinoma Associated with t(X;1)(p11.2;q21)
C37873	t_X_1_p11_q21	Chromosomal_Translocation	t(X;1)(p11.2;q21)
C37874	Renal_Cell_Carcinoma_with_t_X_1_p11_p34	Xp11_Translocation-Related_Renal_Cell_Carcinoma	Renal Cell Carcinoma Associated with t(X;1)(p11.2;p34)
C37875	t_X_1_p11_p34	Chromosomal_Translocation	t(X;1)(p11.2;p34)
C37876	Renal_Cell_Carcinoma_with_t_X_17_p11_q25	Xp11_Translocation-Related_Renal_Cell_Carcinoma	Renal Cell Carcinoma Associated with t(X;17)(p11.2;q25)
C37878	Renal_Cell_Carcinoma_with_t_X_10_p11_q23	Retired_Concepts	Renal Cell Carcinoma Associated with t(X;10)(p11.2;q23)
C37879	t_X_10_p11_q23	Chromosomal_Translocation	t(X;10)(p11;q23)
C37880	t_8_22_p11_q11	Chromosomal_Translocation	t(8;22)(p11;q11)
C37881	BCR-FGFR1_Fusion_Protein_Expression	Fusion_Protein_Expression	BCR-FGFR1 Fusion Protein Expression
C37882	t_4_22_q12_q11	Chromosomal_Translocation	t(4;22)(q12;q11)
C37883	BCR-PDGFRA_Fusion_Protein_Expression	Fusion_Protein_Expression	BCR-PDGFRAlpha Fusion Protein Expression
C37884	TEL-ABL_Fusion_Protein_Expression	Fusion_Protein_Expression	TEL-ABL Fusion Protein Expression
C37885	t_9_12_q34_p13	Chromosomal_Translocation	t(9;12)(q34;p13)
C37886	TEL-JAK2_Fusion_Protein_Expression	Fusion_Protein_Expression	TEL-JAK2 Fusion Protein Expression
C37887	t_9_12_p24_p13	Chromosomal_Translocation	t(9;12)(p24;p13)
C37888	BCR-JAK2_Fusion_Protein_Expression	Fusion_Protein_Expression	BCR-JAK2 Fusion Protein Expression
C37889	Lysis	Cell_Viability_Process	Lysis	Rupture of cell membranes and loss of cytoplasm. (On-line Medical Dictionary)
C37890	t_9_22_p24_q11	Chromosomal_Translocation	t(9;22)(p24;q11)
C37893	Cytotoxic	General_Modifier	Cytotoxic|cytotoxic	Having the ability to kill cells.
C37894	Measurable	Properties_or_Attributes	Measurable|MSRBL	Capable of being measured.
C37895	Residual	General_Modifier	Residual|RSDL	Remaining or left behind.
C37896	Informed	General_Modifier	Informed|INF	Acquainted with knowledge of a subject.
C37897	Proliferation	Conceptual_Entities	Proliferation|PROLIF	Growth and reproduction of new similar forms, e.g. cells, buds, or offspring.
C37899	_17-Allylamino_17-demethoxygeldanamycin	Geldanamycin_Analogue	17-(Allylamino)-17-demethoxygeldanamycin|17-AAG|17-Allyl-aminogeldanamycin|17-Allylamino-17-demethoxy-geldanamycin|17-Allylamino-17-demethoxygeldanamycin|17-Demethoxy-17-(2-propenylamino)geldanamycin|17-N-Allylamino-17-demethoxy geldanamycin|17-N-allylamino-17-demethoxy geldanamycin|Geldanamycin, 17-allylamino-17-demethoxy-	A benzoquinone antineoplastic antibiotic derived from the antineoplastic antibiotic geldanamycin.  17-allylamino 17-demethoxygeldanamycin binds to and inhibits the cytosolic chaperone functions of heat shock protein 90 (HSP90).  HSP90 maintains the stability and functional shape of many oncogenic signaling proteins; the inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins that may be overexpressed by tumor cells. (NCI04)
C37900	Provider	Conceptual_Entities	Provider|PROV	One that makes something available.
C37901	Site	Conceptual_Entities	Site|Sites	A position in relation to its surroundings.
C37902	Support	Conceptual_Entities	Support	Support; approval; moral, psychological, physical, or financial aid or assistance.
C37903	Intestinal_Mass	Abdominal_Mass	Intestinal Mass
C37904	Colonic_Mass	Intestinal_Mass	Colonic Mass
C37905	Gain_of_Chromosome_14	Chromosomal_Gain	Gain of Chromosome 14
C37906	Acidosis	Retired_Concepts	Acidosis	An abnormally high acidity (excess hydrogen-ion concentration) of the blood and other body tissues.
C37907	Age-Months	Age	Age-Months	The length of a person's life, stated in months since birth.
C37908	Age-Years	Age	Age-Years	The length of a person's life, stated in years since birth.
C37909	Alkalosis	Electrolyte_Disorder	Alkalosis	An abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues.
C37910	Allergic	Personal_Attribute	Allergic	Pertaining to, caused by, affected with or of the nature of allergy. (On-line Medical Dictionary)
C37912	And	Conceptual_Entities	And	An article which expresses the relation of connection or addition. It is used to conjoin a word with a word, a clause with a clause, or a sentence with a sentence.
C37913	Arachnoiditis	Inflammation	Arachnoiditis	Inflammation of the arachnoid membrane and adjacent subarachnoid space. (On-line Medical Dictionary)
C37914	Atrial	Anatomy_Modifier	Atrial	Of or relating to a cavity or chamber in the body, especially one of the upper chambers of the heart.
C37915	Auditory	General_Modifier	Auditory	Of or relating to the process of hearing.
C37916	Autoimmune	General_Modifier	Autoimmune	Pertaining to autoimmunity.
C37917	Average	General_Modifier	Average|AVG	A statistical calculation describing the central tendency of a set of numbers; used to interpret quantitative data.
C37918	Bicarbonate	Ions	Bicarbonate	A polyatomic ion whose formula is HCO3-.
C37919	Blur	Properties_or_Attributes	Blur	A dim, vague appearance.
C37920	Bradycardia	Cardiovascular_System_Signs_and_Symptoms	Bradycardia	An abnormally slow heartbeat; as applied in adult medicine, it is defined as a heart rate of under 60 beats per minute. (from Wikipedia)
C37921	Bruising	Injury	Bruising	To injure the underlying soft tissue or bone of (part of the body) without breaking the skin, as by a blow. (from Dictionary.com)
C37922	Callback	Healthcare_Activity	Callback|CB	Callback is the act or an instance of returning from one location or situation to the previous one. Concept also refers to a return telephone or radio call, particularly when a survey is conducted; and to a recall of a recently sold product (e.g. pharmaceutical) by the manufacturer. In computer science, a callback is an argument passed from a parent function to a child function; the callback argument is itself a third function.
C37923	Cellularity	Anatomy_Modifier	Cellularity	The degree, quality, or condition of cells that are present. (On-line Medical Dictionary)
C37925	Clone	Specimen	Clone	A group of genetically identical cells, organisms, or DNA molecules.
C37926	Cognitive	General_Modifier	Cognitive	Cognitive; of or being or relating to or involving cognition.
C37927	Color	Appearance	Color	The appearance of objects (or light sources) described in terms of a person's perception of their hue and lightness (or brightness) and saturation.
C37928	Confusion	Symptom	Confusion	Confusion; a mental state characterized by a lack of clear and orderly thought and behavior.
C37929	Consciousness	Conceptual_Entities	Consciousness	Sense of awareness of self and of the environment.
C37930	Constipation	Disturbance_in_Bowel_Function	Constipation	Constipation; irregular and infrequent or difficult evacuation of the bowels.
C37931	Constitutional	General_Modifier	Constitutional	Constitutional; existing as an essential characteristic.
C37932	Contraception	Healthcare_Activity	Contraception	The prevention of conception or impregnation by the use of devices or drugs or surgery.
C37933	Contraindicated	Conceptual_Entities	Contraindicated|CON	State of a particular method of treatment, regimen, procedure, medication, etc. of being unsuitable and inadvisable, often because of a likely adverse reaction.
C37934	Corrected	Conceptual_Entities	Corrected|CORR	Corrected; having had errors or mistakes removed.
C37935	Cough	Symptom	Cough	A cough is a sudden, often repetitive, spasmodic contraction of the thoracic cavity, resulting in violent release of air from the lungs, and usually accompanied by a distinctive sound. (from Wikipedia)
C37936	Cranial	Anatomy_Modifier	Cranial	Of or relating to the cranium.
C37937	Creatine	Heterocyclic_Compound	Creatine|Glycine, N-(aminoiminomethyl)-N-methyl-	An endogenous amino acid derivative produced by vertebrate animals and occurring primarily in muscle cells.  Creatine is important for energy storage; it is phosphorylated to creatine phosphate, which serves as a phosphate donor in the conversion of ADP to ATP and supplies energy necessary for muscle contraction.  Dietary supplementation with creatine may improve muscle wasting associated with cancer and other chronic diseases.
C37938	Cushingoid	Disease_Modifier	Cushingoid	Resembling the signs and symptoms of Cushing's disease or syndrome: buffalo hump obesity, striations, adiposity, hypertension, diabetes, and osteoporosis, usually due to exogenous corticosteroids. (On-line Medical Dictionary)
C37939	Date_Time	Temporal_Modifier	Date and Time|DT-TM|Date/Time	An expression of both date and time that an event has happened or will happened.
C37940	Deficit	Conceptual_Entities	Deficit|DEF	Deficit; a lack or deficiency.
C37941	Diplopia	Visual_Manifestations	Diplopia	The condition in which a single object appears as two objects. Also called "double vision." (from medterms.com)
C37942	Distress	Other_Finding	Distress	Distress; extreme physical pain or psychological suffering.
C37943	Dizziness	Neurological_Signs_and_Symptoms	Dizziness	Dizziness is a medically indistinct term used to describe a variety of conditions such as lightheadedness, unsteadiness, giddiness, a sense of turning, spinning or rocking.
C37944	Earache	Pain	Earache	Earache; a pain localized in the middle or inner ear.
C37945	Echocardiogram	Medical_Image	Echocardiogram	An image of the heart produced by ultrasonography.
C37946	Ejection_Fraction	Cardiovascular_System_Finding	Left Ventricular Ejection Fraction|EFRAC|Ejection Fraction|LVEF	A measure of how much blood the left ventricle of the heart pumps out with each contraction. With each beat, a normal heart ejects about one-half to two-thirds of the blood in its left chamber.
C37947	Engraftment	Treatment	Engraftment	The establishment of viable, functional grafted tissue within the body of a host.
C37948	Enrollment	Clinical_or_Research_Activity	Enrollment	The act of registration, entering in a list, catalog, group, study; also, the number of subjects enrolled.
C37949	Entered	General_Modifier	Entered|ENT	Having made a record of, set down in permanent form, or formally registered to participate in an activity.
C37950	Esophageal	Anatomy_Modifier	Esophageal|esophageal	(eh-SOF-a-JEE-al) Having to do with the esophagus, the muscular tube through which food passes from the throat to the stomach.
C37951	Feminine	General_Modifier	Feminine	Feminine; associated with women.
C37953	Flare	Integumentary_System_Signs_and_Symptoms	Flare	Flare; reddening of the skin spreading outward from a focus of infection or irritation; a sudden recurrence or worsening of symptoms.
C37954	Flatulence	Gastrointestinal_System_Signs_and_Symptoms	Flatulence	Flatulence; a state of excessive gas in the alimentary canal.
C37955	Floaters	Visual_Manifestations	Floaters	Floaters; spots before the eyes caused by opaque cell fragments in the vitreous humor or lens.
C37956	Gain	General_Modifier	Gain	Gain; to increase or the amount of increase.
C37957	Geographic	General_Modifier	Geographic|GEO	Geographic; of or relating to the science of geography; determined by geography.
C37958	Germ	Conceptual_Entities	Germ	Germ; something that may serve as the basis of further growth or development.
C37959	Gamma-Glutamyl_Transpeptidase	Transferase	Gamma-Glutamyl Transpeptidase|GGT|Gamma-GT	GGT participates in the transfer of amino acids across the cellular membrane and in glutathione metabolism. High concentrations are found in the liver, bile ducts, and the kidney.  A test that measures the amount of GGT in the blood is used to detect diseases of the liver, bile ducts, and kidney; and to differentiate liver or bile duct (hepatobiliary) disorders from bone disease. (from http://health.allrefer.com)
C37960	Graph	Document_Type	Graph	A drawing illustrating the relations between certain quantities plotted with reference to a set of axes.
C37961	Hallucination	Sensory_Manifestations	Hallucination	A hallucination is a false sensory perception in the absence of an external stimulus, as distinct from an illusion which is a misperception of an external stimulus. (from Wikipedia)
C37962	Haptoglobin	Ligand_Binding_Protein	Haptoglobin|HP	A plasma protein that is a normal constituent of blood serum and functions in the binding of free hemoglobin in the bloodstream. (Dictionary.com)
C37963	Harvest	Procedure	Harvest	Remove from a culture or a living or dead body, as for the purposes of transplantation.
C37964	Hematemesis	Vomiting	Hematemesis	Hematemesis; vomiting blood.
C37965	Hemolysis	Lysis	Hemolysis	Disruption of the integrity of the red cell membrane causing release of hemoglobin. (On-line Medical Dictionary)
C37966	Hiccough	Alteration_in_Respiration	Hiccough|Hiccup|Hiccups|Singultus	A diaphragmatic spasm causing a sudden inhalation which is interrupted by a spasmodic closure of the glottis, producing a noise. (On-line Medical Dictionary)
C37967	Hypercholesterolemia	Abnormal_Blood_and_Hematology_Test_Result	Hypercholesterolemia	Hypercholesterolemia; the presence of an abnormal amount of cholesterol in the cells and plasma of the blood.
C37968	Hyperkalemia	Abnormal_Blood_and_Hematology_Test_Result	Hyperkalemia	Hyperkalemia; higher than normal levels of potassium in the circulating blood; associated with kidney failure or sometimes with the use of diuretic drugs.
C37969	Hypermagnesemia	Abnormal_Blood_and_Hematology_Test_Result	Hypermagnesemia	Hypermagnesemia; higher than normal levels of magnesium in the circulating blood.
C37970	Hypernatremia	Abnormal_Blood_and_Hematology_Test_Result	Hypernatremia	Hypernatremia; higher than normal levels of sodium in the circulating blood.
C37971	Hypertriglyceridemia	Abnormal_Blood_and_Hematology_Test_Result	Hypertriglyceridemia	Hypertriglyceridemia; the condition of elevated triglyceride concentration in the blood.
C37972	Hypoalbuminemia	Abnormal_Blood_and_Hematology_Test_Result	Hypoalbuminemia	Hypoalbuminemia; an abnormally low blood level of albumin.
C37973	Hypocalcemia	Abnormal_Blood_and_Hematology_Test_Result	Hypocalcemia	Hypocalcemia; lower than normal levels of calcium in the circulating blood.
C37974	Hypokalemia	Abnormal_Blood_and_Hematology_Test_Result	Hypokalemia	Hypokalemia; lower than normal levels of potassium in the circulating blood.
C37975	Hypomagnesemia	Abnormal_Blood_and_Hematology_Test_Result	Hypomagnesemia	Hypermagnesemia; lower than normal levels of magnesium in the circulating blood.
C37976	Hyponatremia	Abnormal_Blood_and_Hematology_Test_Result	Hyponatremia	Hypernatremia; lower than normal levels of sodium in the circulating blood.
C37977	Hypophophatemia	Abnormal_Blood_and_Hematology_Test_Result	Hypophosphatemia	Hypophosphatemia; lower than normal levels of phosphates in the circulating blood.
C37978	International_Classification_of_Disease_for_Oncology	Book	International Classification of Disease for Oncology|ICD-O	The International Classification of Disease for Oncology has been used for nearly 25 years as a tool for coding diagnoses of neoplasms in tumor and cancer registrars and in pathology laboratories. ICD-O is a dual classification with coding systems for both topography and morphology. The topography code describes the site of origin of the neoplasm. The morphology code describes the characteristics of the tumor itself, including its cell type and biologic activity. (from Amazon.com)
C37979	Ileus	Bowel_Obstruction	Ileus	An obstruction of the intestines, especially the ileum.
C37980	Inner	General_Modifier	Inner	Inner; inside or closer to the inside of the body.
C37981	Intubation	Procedure	Intubation	Intubation; the insertion of a cannula or tube into a hollow body organ.
C37984	Laboratory	Clinical_or_Research_Facility	Laboratory|Lab	A workplace for the conduct of scientific research.
C37986	Libido	Personal_Attribute	Libido	Sexual urge or desire.
C37987	Life	Conceptual_Entities	Life	Life; the organic phenomenon that distinguishes living organisms from nonliving ones.
C37988	Lipase	Esterase	Lipase	Lipase; an enzyme secreted in the digestive tract that catalyzes the breakdown of fats into individual fatty acids that can be absorbed into the bloodstream.
C37989	Masculine	General_Modifier	Masculine	Masculine; associated with men.
C37990	Measurement	Retired_Concepts	Measurement	Measurement is the act or process of determining the size or magnitude of something; the size or magnitude of something.
C37992	Memory	Mental_Process	Memory	Memory; the power of retaining and recalling past experience, something that is remembered.
C37993	Mitotic	General_Modifier	Mitotic	Pertaining to mitosis.
C37994	Movement	Conceptual_Entities	Movement	A change in location or position.
C37995	North_American_Brain_Tumor_Consortium	NCI_Consortium_or_Network	North American Brain Tumor Consortium|NABTC	Dedicated to the development and conduct of innovative clinical trials that will ultimately result in a cure for patients with malignant brain tumors. Their goals are 1) to discover new and effective therapies for the treatment of patients with brain tumors, including anti-angiogenesis drugs, differentiating agents, anti-invasive medications, and new molecular agents such as gene therapy; 2) to develop innovative combination strategies to enhance the therapeutic effects of chemotherapy and radiation treatments; and 3) to develop and fund translational research opportunities that will bring exciting new agents and strategies from the laboratory to the clinical setting. (http://www.nabtc.org)
C37996	New_Approaches_to_Brain_Tumor_Therapy_Consortium	NCI_Consortium_or_Network	New Approaches to Brain Tumor Therapy Consortium|NABTT	The primary objective of the "New Approaches to Brain Tumor Therapy (NABTT)" CNS Consortium is to improve the therapeutic outcome for adults with primary brain tumors. It is funded by the National Cancer Institute to conduct Phase I and II clinical evaluations of promising new treatment strategies (surgery, radiation, chemotherapy, and biologic therapies), routes of administration, and clinical trial design in the treatment of primary malignancies of the central nervous system. The secondary objective of the NABTT CNS Consortium is to share human brain tumor specimens and clinical and laboratory data to conduct additional research pertaining to 1) the basic biology of primary brain tumors, 2) the neuro-pharmacology of new therapies for primary brain tumors, and 3) improving the care and quality of life of adults with primary brain tumors. (http://www.nabtt.org)
C37997	Nyctalopia	Visual_Manifestations	Nyctalopia	Nyctalopia; inability to see clearly in dim light.
C37998	Or	Conceptual_Entities	Or	Or; used to connect words, phrases, or clauses representing alternatives; used to connect alternative terms for the same thing; used in correlation; used to correct or rephrase what was previously said; otherwise.
C37999	Palpitations	Cardiovascular_System_Signs_and_Symptoms	Palpitation|Palpitations	Palpitations; unpleasant sensation of irregular and/or forceful beating of the heart.
C38000	Performed	Properties_or_Attributes	Performed|PERF	Executed and carried through to completion.
C38001	Pericardial	Anatomy_Modifier	Pericardial	Located around the heart or relating to or affecting the pericardium.
C38002	Personality	Personal_Attribute	Personality	The complex of all the attributes--behavioral, temperamental, emotional and mental--that characterize a unique individual.
C38003	Phlebitis	Vascular_Disorder	Phlebitis	Phlebitis; inflammation of a vein.
C38004	Photosensitivity	Symptom	Photosensitivity	Photosensitivity; increased sensitivity of the skin to light and other sources of UV.
C38005	Pigmentation	Personal_Attribute	Pigmentation	Pigmentation; the coloring of the skin, hair, mucous membranes, and retina of the eye.
C38006	Pneumothorax	Non-Neoplastic_Pleural_Disorder	Pneumothorax	Pneumothorax; abnormal presence of air in the pleural cavity resulting in the collapse of the lung.
C38007	Portal	Anatomy_Modifier	Portal	Of or pertaining to a porta, especially the porta of the liver; as, the portal vein, which enters the liver at the porta, and divides into capillaries after the manner of an artery. Portal is applied to other veins which break up into capillaries; as, the renal portal veins in the frog. (On-line Medical Dictionary)
C38008	Post	Temporal_Modifier	Post	Occuring after in time.
C38009	Postal	General_Modifier	Postal	Of or relating to the system for delivering mail.
C38010	Pre-study	Temporal_Modifier	Pre-study|PS	Pre-study; occurring before enrollment/treatment on-study.
C38011	Proctitis	Anal_Disorder	Proctitis	Proctitis; inflammation of the rectum.
C38012	Proteinuria	Abnormal_Urine_Test_Result	Proteinuria	Proteinuria; the presence of excessive protein, chiefly albumin but also globulin, in the urine.
C38013	Range	Conceptual_Entities	Range	The difference between the lowest and highest numerical values.
C38014	Refractory	Disease_Treatment_Modifier	Refractory|REFRAC	Refractory; not responding to treatment.
C38015	Requirement	Conceptual_Entities	Requirement|REQ	Something that is necessary; condition, something that is obligatory.
C38016	Retention	Conceptual_Entities	Retention	The condition of remaining in a place or position or of holding within.
C38017	Salivary	Anatomy_Modifier	Salivary	Salivary; of or relating to saliva.
C38019	Shared	General_Modifier	Shared|Sharing	Shared; have in common; held or experienced in common.
C38020	Shortening_Fraction	Test|Test_Generic	Shortening Fraction|SFRAC	Shortening fraction is a way of measuring performance of left ventricle.  It measures and ratios the change in the diameter of the left ventricle between the contracted and relaxed states: the difference between LV end-diastolic diameter and LV end-systolic diameter over LV end-diastolic diameter.
C38021	Syndrome_of_Inappropriate_Antidiuretic_Hormone_Secretion	Retired_Concepts	Syndrome of Inappropriate Antidiuretic Hormone Secretion
C38023	Smell	Retired_Concepts	Smell	Smell; the faculty of smell, the sensation that results when olfactory receptors in the nose are stimulated by particular chemicals in gaseous form.
C38024	Specified	General_Modifier	Specified|SPEC	Specified; clearly and explicitly stated.
C38025	Speech	Organismal_Process	Speech	Speech; the exchange of spoken words.
C38026	Spinal	Anatomy_Modifier	Spinal	Spinal; of or relating to the spine or spinal cord.
C38027	Stage_Grouping	Healthcare_Activity	Stage Grouping|STG	Stage Grouping; an assessment based on the combined evaluation of the patient's T stage, M stage, and N stage.
C38028	Swallowing	Gastrointestinal_Process	Swallowing	Swallowing; the act of passing something through the mouth and throat into the stomach.
C38029	Tachycardia	Cardiovascular_System_Signs_and_Symptoms	Tachycardia	Tachycardia; an abnormally rapid heartbeat, usually applied to a heart rate above 100 per minute.
C38030	Taste	Retired_Concepts	Taste	Taste; the faculty of taste, distinguishing substances by means of the taste buds.
C38031	Tearing	Symptom	Tearing	Tearing; excessive shedding of tears.
C38032	Therapeutic_Effect	Biological_Effect_of_Chemicals	Therapeutic Effect|TE	Beneficial responses or outcomes in the prevention, treatment, or progression of a disease resulting from drug therapy.  Therapeutic effect also includes prevention or reduction of adverse effects. (NCI)
C38033	Arthroscopy	Endoscopy	Arthroscopy
C38034	Topography	Conceptual_Entities	Topography	Topography; the description of an anatomical region or of a body part.
C38036	Audiometric_Test	Procedure	Audiometric Test|Audiogram|Audiometry	Audiometric testing (hearing test) is conducted utilizing a manual or microprocessor audiometer. The test is usually carried out in a sound room or sound test chamber. Used to test for hearing loss.
C38037	Total_Bilirubin	Procedure	Total Bilirubin|TBILI	Bilirubin is a breakdown product of hemoglobin. Total and direct bilirubin are usually measured to screen for or to monitor liver or gall bladder dysfunction. (from MedlinePlus Medical Encyclopedia)
C38038	Tremor	Motor_Manifestations	Tremor	Tremor is the shaking movement of the whole body or just a certain part of it, often caused by problems of the neurons responsible for muscle action. (from Wikipedia)
C38039	Bone_Spectrometry	Procedure	Bone Spectrometry
C38040	Bronchography	Procedure	Bronchography|BRNCHGRM
C38041	Troponin_T	Microfilament_Protein	Troponin T	Troponin I, troponin T, and troponin C are the three closely associated subunits of the troponin complex of thin filaments in muscle.  The complex serves as a calcium-sensitive switch that regulates muscle contraction.  Because it is not normally found in blood, cardiac troponin-T in serum is a sensitive indicator of myocardial cell injury.
C38042	Bronchoscopy_with_Bronchoalveolar_Lavage	Bronchoscopy	Bronchoscopy with Bronchoalveolar Lavage|Bronchoscopy/Lavage
C38043	Typhlitis	Regional_Enteritis	Typhlitis	Typhlitis; inflammation of the cecum.
C38044	Cardiac_Catheterization	Catheterization	Cardiac Catheterization
C38045	Catheterization	Procedure	Catheterization|Cathetergram	Catheterization is a technique in which a hollow, flexible tube is used to drain body fluids or to introduce fluids into the body, or to examine or widen a narrowed vein or artery.
C38046	Unspecified	Missing_Value_Reason	Unspecified|Not Specified|UNS	Not stated explicitly or in detail.
C38047	Curative_Surgery	Procedure	Curative Surgery
C38048	Vasovagal	Anatomy_Modifier	Vasovagal	Vasovagal; relating to the action of the vagus nerve upon the blood vessels.
C38049	Cystography	Radiography	Cystography
C38050	Veno-occlusive	Disease_Modifier	Veno-occlusive	Veno-occlusive; pertaining to or characterized by obstruction of the veins.
C38052	Dental_Procedure	Procedure	Dental Procedure
C38053	Electrocardiography	Procedure	Electrocardiography|CEKG|ECG|EKG
C38054	Electroencephalography	Procedure	Electroencephalography|EEG
C38055	Ventricular	Anatomy_Modifier	Ventricular	Ventricular; of or relating to a ventricle (of the heart or brain).
C38056	Electromyography	Procedure	Electromyography|EMG
C38057	Vertigo	Neurological_Signs_and_Symptoms	Vertigo	Vertigo is a feeling of movement, a sensation as if the external world were revolving around the patient (objective vertigo) or as if he himself were revolving in space (subjective vertigo).  Vertigo is medically distinct from dizziness, lightheadedness, and unsteadiness.
C38058	Thallium_Myocardial_Perfusion_Imaging_Stress_Test	Procedure	Thallium Myocardial Perfusion Imaging Stress Test|Exercise Thallium|Stress Thallium Test
C38059	Visual	General_Modifier	Visual	Visual; relating to or using sight; able to be seen.
C38060	Eye_Examination	Examination	Eye Examination|Eye Exam
C38061	Withdrawn	General_Modifier	Withdrawn|WD	Withdrawn; having ceased active participation in.
C38062	Blood_Flow_Cytometry	Procedure	Blood Flow Cytometry|Flow Cytometry, Blood
C38063	Bone_Marrow_Cytometry	Procedure	Bone Marrow Cytometry|Flow Cytometry, Bone Marrow
C38064	Holter_Monitoring	Procedure	Holter Monitoring|HOLTMON|Holter Electrocardiography|Holter Monitor
C38065	Hyperbaric_Oxygen_Therapy	Treatment	Hyperbaric Oxygen Therapy|Hyperbaric Therapy|Hyperbaric Treatment(s)
C38066	Hysterosonography	Procedure	Hysterosonography
C38067	Incision_and_Drainage	Procedure	Incision and Drainage|I&D|Incision & Drainage
C38068	Lavage	Procedure	Lavage|Irrigation
C38069	Lymphangiography	Endoscopy	Lymphangiography|LAG
C38070	Lymphocyte_Harvest	Harvest	Lymphocyte Harvest	Lymphocyte Harvest; remove lymphocytes from a culture or a living or dead body, as for the purposes of transplantation.
C38071	Breast_Imaging_Reporting_and_Data_System_Mammography	Mammography	Breast Imaging Reporting and Data System Mammography|Mammogram, BIRAD
C38072	Wolfe_Classification_Mammography	Mammography	Wolfe Classification Mammography|Mammography, WOLFE
C38073	Radionuclide_Ventriculogram_Scan	Scanning_Procedure_or_Technique	Radionuclide Ventriculogram Scan|MUGA|MUGASCAN|Multi-Gated Acquisition Scan
C38074	Nasopharyngeal_Laryngoscopy	Endoscopy	Nasopharyngeal Laryngoscopy
C38075	Nasopharyngoscopy	Endoscopy	Nasopharyngoscopy
C38076	Nipple_Discharge_Aspiration	Procedure	Nipple Discharge Aspiration|Nipple Suction Aspiration
C38077	Ommaya_Reservoir_Access	Procedure	Ommaya Reservoir Access|Ommaya Resevoir Tap
C38078	Percutaneous_Transluminal_Coronary_Angioplasty	Procedure	Percutaneous Transluminal Coronary Angioplasty|PTCA
C38079	Peritoneoscopy	Endoscopy	Peritoneoscopy
C38080	Portacath_Placement	Procedure	Portacath Placement|Port-a-cath Placement
C38081	Pulmonary_Function_Test	Test|Test_Generic	Pulmonary Function Test
C38082	Inspired_Oxygen_Fraction_Test	Pulmonary_Function_Test	Inspired Oxygen Fraction Test|PFT/FIO2|Pulmonary Function Test/ Inspired Oxygen Fraction
C38083	Carbon_Monoxide_Diffusing_Capability_Test	Pulmonary_Function_Test	Carbon Monoxide Diffusing Capability Test|PFT/DLCO|Pulmonary Function Test/Carbon Monoxide Diffusing Capability
C38084	Forced_Expiratory_Volume_1_Test	Pulmonary_Function_Test	Forced Expiratory Volume in 1 Second|FEV1|FEV1%VC|Forced Expiratory Volume 1 Test|PFT/FEV1|Pulmonary Function Test/Forced Expiratory Volume 1	A test of lung function, the FEV1 is the volume exhaled during the first second of a forced expiratory maneuver started from the level of total lung capacity. It is the most frequently used index for assessing bronchoconstriction or bronchodilatation. (from http://www.spirxpert.com/indices7.htm)
C38085	Pulse_Oximetry	Procedure	Pulse Oximetry
C38086	Renography	Radiography	Renography
C38087	Gallium_Scan	Scanning_Procedure_or_Technique	Gallium Scan|Scan, Gallium
C38088	I-131_Uptake_and_Scan	Scanning_Procedure_or_Technique	I-131 Uptake Test|I-131 Uptake and Scan|Scan, I 131 Uptake	Radioactive Iodine Uptake is a type of nuclear test of the thyroid that measures how much radioactive iodine is taken up by the thyroid gland in a given time period. This test is performed to evaluate thyroid function, particularly when blood tests of thyroid function (for example, T3 or T4 levels) have abnormal results. (from Medline Plus Medical Encyclopedia)
C38089	Indium_Scan	Scanning_Procedure_or_Technique	Indium Scan|Scan, Indium
C38090	Lung_Perfusion_Scan	Scanning_Procedure_or_Technique	Lung Perfusion Scan|Scan, Lung Perfusion
C38091	Sestamibi_Scan	Scanning_Procedure_or_Technique	Sestamibi Scan|Scan, Sestamibi
C38092	Skeletal_Survey_X-Ray	Radiography	Skeletal Survey X-Ray|SKELSURV|Skeletal Survey
C38093	Tomography	Procedure	Tomography
C38094	Small_Bowel_Follow_Through_Procedure	Radiography	Small Bowel Follow Through Procedure
C38095	Urine_Casts	Urinary_Tract_Finding	Urine Casts|Urinary Casts	Tubules in the kidneys secrete proteins. Under some circumstances, these proteins precipitate out to form little cylindrical impressions of the tubules called casts. If anything is present in the tubules at the time, it gets trapped in the protein casts. This offers a "snap shot" of the tubular lumen at the time of cast formation. (from Medline Plus)
C38096	Vaginography	Radiography	Vaginography
C38097	Vascular_Access_Device_Placement	Procedure	Vascular Access Device Placement
C38098	Venacavography	Angiography	Venacavography
C38099	Venography	Angiography	Venography
C38100	Ventilation_Perfusion_Scanning	Procedure	Ventilation Perfusion Scanning|Ventilation-Perfusion Scan
C38101	Radiography	Procedure	Radiography|X-Ray|XRAY
C38102	Abdominal_Radiography	Radiography	Abdominal Radiography|KUB|X-Ray, Abdominal
C38103	Chest_Radiography	Radiography	Chest Radiography|CXR|X-ray, Chest
C38104	Pelvic_Examination	Physical_Examination	Pelvic Examination|Pelvic Exam
C38105	Myoid_Dermatofibrosarcoma_Protuberans	Dermatofibrosarcoma_Protuberans	Myoid Dermatofibrosarcoma Protuberans
C38106	Myxoid_Dermatofibrosarcoma_Protuberans	Dermatofibrosarcoma_Protuberans	Myxoid Dermatofibrosarcoma Protuberans
C38107	Dedifferentiated_Dermatofibrosarcoma_Protuberans	Dermatofibrosarcoma_Protuberans	Dedifferentiated Dermatofibrosarcoma Protuberans
C38108	Dermatofibrosarcoma_Protuberans_with_Giant_Cell_Fibroblastoma-Like_Differentiation	Dermatofibrosarcoma_Protuberans	Dermatofibrosarcoma Protuberans with Giant Cell Fibroblastoma-Like Differentiation
C38109	Basosebaceous_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma	Skin Basosebaceous Basal Cell Carcinoma
C38110	Signet_Ring_Cell_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma	Skin Signet Ring Cell Basal Cell Carcinoma
C38111	Sarcomatoid_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma|Sarcomatoid_Carcinoma	Skin Sarcomatoid Basal Cell Carcinoma
C38112	Esophagography	Radiography	Esophagography|Barium Swallow|Contrast Esophagraphy|barium swallow	The process of obtaining contrast esophagrams.
C38113	Cytology_Specimen_Collection_Procedure	Procedure	Cytology Specimen Collection Procedure|Cytology
C38114	Drug_Route_of_Administration	Route	Route of Administration|ROUTE OF ADMINISTRATION	The course by which a substance was administered in order to reach the site of action in the body. It is primarily determined by the properties of the substance and therapeutic objectives. The pharmacokinetic parameters of the drug are critically influenced by the route of administration. The major distinction between routes of administration is whether the drug takes effect merely in the local area where it is applied or whether it reaches targeted destination through the systemic circulation. In latter case the substance is a subject to possible first-pass effect in the lung, liver, and other organs. (NCI)
C38115	Estradiol_Mustard	Nitrogen_Mustard_Compound	Estradiol Mustard|p-(N,N-bis(2-chloroethyl)amino)phenylacetic acid 17-beta-estradiol diester	A conjugate of two agents, estradiol and an alkylating mustard (usually mechlorethamine or non-nitrogen mustard). Estramustine is one such agent (see Estramustine Phosphate Sodium).  (NCI04)
C38116	Murine_Monoclonal_Antibody_225	Epidermal_Growth_Factor_Receptor_Tyrosine_Kinase_Inhibitor|Monoclonal_Antibody	Murine Monoclonal Antibody 225|Anti-EGF Receptor IgG1(Hybritech)
C38117	HPV_16_E6_18-26_Peptide	Human_Papillomavirus_16_E6_Peptide	HPV 16 E6 (18-26) Peptide|HPV 16 E6:18-26	A peptide derived from the oncogenic human papillomavirus (HPV) early gene product E6.  The HPV 16 transforming protein E6 is expressed in precancerous and malignant cervical lesions and has a high affinity for the most common human lymphocyte antigen (HLA), HLA-A2.  Immunogenic peptides from the HPV 16 E6 may be used to trigger a T-cell-mediated immune response to HPV. (NCI04)
C38118	SBIL-2_Transduced_Autologous_Tumor-Infiltrating_Lymphocyte	Biological_Agent	SBIL-2 Transduced Autologous Tumor-Infiltrating Lymphocyte	A population of tumor-infiltrating lymphocytes (TILs) harvested from a patient and transduced with a retroviral vector encoding the gene for interleukin-2 (IL-2).  TILs require IL-2 to sustain them when they are transferred back to the patient.  By inserting the IL-2 gene into TILs in vitro so that TILs express IL-2 continuously it is possible to provide TIL-sustaining IL-2 in vivo specifically at the site of lymphocyte infiltration, thereby avoiding the toxicity associated with the systemic administration of IL-2. (NCI04)
C38119	ESO-1_Reactive_Autologous_Peripheral_Blood_Lymphocyte	Biological_Agent	ESO-1 Reactive Autologous Peripheral Blood Lymphocyte	Human peripheral blood lymphocytes (PBL) isolated from a patient, exposed to the tumor-associated protein ESO-1 in vitro, and then transferred back to the same patient to target tumor cells expressing ESO-1. ESO-1 is a human self-antigen expressed by melanomas. The ESO-1 gene encodes several MHC class I- and MHC class II-restricted epitopes that may activate cytotoxic T-cell-mediated tumor destruction. (NCI04)
C38120	ESO-1_Reactive_Autologous_Tumor_Infiltrating_Lymphocyte	Biological_Agent	ESO-1 Reactive Autologous Tumor Infiltrating Lymphocyte	Tumor infiltrating lymphocytes (TIL) isolated from a patient, exposed to the tumor-associated protein ESO-1 in vitro, and then transferred back to the same patient to target tumor cells expressing ESO-1. ESO-1 is a human self-antigen expressed by melanomas. The ESO-1 gene encodes several MHC class I- and MHC class II-restricted epitopes which may activate cytotoxic T-cell-mediated tumor destruction. (NCI04)
C38121	PR-151	Vaccine_Antigen	PR-151|p53:FrSh134 (LPTGQDL)
C38122	VHL-42_65-76	Von_Hippel-Lindau_Peptide_Vaccine	VHL-42: 65-76|V74G	A peptide (amino acids 65-76) derived from the tumor suppressor protein Von Hippel-Lindau (VHL). As a cancer vaccine, VHL-59: 65-76 may stimulate a cytotoxic T-cell response to VHL-associated tumors.  (NCI04)
C38123	VHL-59_116-128	Von_Hippel-Lindau_Peptide_Vaccine	VHL-59: 116-128|FrSh 116-128	A peptide (amino acids 116 to 128) derived from the tumor suppressor protein Von Hippel-Lindau (VHL). As a cancer vaccine, VHL-59: 116-128 may stimulate a cytotoxic T-cell response to VHL-associated tumors. (NCI04)
C38124	gp100-Reactive_Autologous_Peripheral_Blood_Lymphocyte	Biological_Agent	gp100-Reactive Autologous Peripheral Blood Lymphocyte|gp100-Reactive Autologous PBL	Human peripheral blood lymphocytes (PBL) isolated from a patient, exposed to the tumor-associated antigen gp100 in vitro, and then transferred back to the same patient to target tumor sites expressing gp100. gp100 human antigen is a wild-type self-antigen expressed by melanocytes, pigmented retinal cells and most melanomas. (NCI04)
C38125	gp100-Reactive_Autologous_Tumor_Infiltrating_Lymphocyte	Biological_Agent	gp100-Reactive Autologous Tumor Infiltrating Lymphocyte|gp100-Reactive Autologous TIL	Tumor infiltrating lymphocytes (TIL) isolated from a patient, exposed to the tumor-associated antigen gp100 in vitro, and then transferred back to the same patient to target tumor cells expressing gp100. gp100 human antigen is a wild-type self-antigen expressed by melanocytes, pigmented retinal cells and most melanomas. (NCI04)
C38126	Betulinic_Acid	Immunostimulant	Betulinic Acid|(3beta)-3-Hydroxy-lup-20(29)-en-28-oic Acid|Mairin	A natural pentacyclic triterpene isolated from plants (Acacia mellifera), Betulinic Acid displays cytotoxic properties, induces cell cycle arrest in G1 and G2/M, and causes apoptosis in melanoma, and other, tumor cells. Betulinic Acid may suppress metastasis of melanoma cells and is in study as a chemotherapeutic supplement for malignant melanoma and other forms of cancers. (NCI04)
C38127	_6-Aminonicotinamide	Radiosensitizing_Agent	6-Aminonicotinamide|6-AN|Aminonicotinamide|U-8774	A synthetic analogue and nicotinamide antagonist with cytotoxic properties, 6-Aminonicotinamide forms an abnormal NAD (ubiquitous metabolic pathway coenzyme) analog that inhibits NAD-dependent enzyme activity associated with ATP production. 6-Aminonicotinamide impairs cartilage formation, may have teratogenic effects, and enhances the effect of radiation and cisplatin treatment (formation of platinum-DNA complexes). (NCI04)
C38129	PPI-2458	Endothelial_Cell_Inhibitor	PPI-2458	A synthetic derivative of fumagillin with antineoplastic and cytotoxic properties.  PPI-2458 irreversibly inhibits the enzyme methionine aminopeptidase type 2 (MetAP2), thereby preventing abnormal cell growth and angiogenesis. PPI-2458 is reported to have a better toxicity profile compared to other agents of its class. (NCI04)
C38130	SL11093	Polyamine_Inhibitory_Agent	SL11093	A synthetic compound of the polyamine class of chemicals with potential antineoplastic activity. Natural endogenous polyamines bind to DNA and are involved in a number of cellular processes such as cell division, differentiation, and membrane function. SL11093 displaces these polyamines from their DNA binding sites, resulting in cessation of cell growth and cell death. (NCI04)
C38131	SB-715992	Antimitotic_Agent	SB-715992|CK0238273	A synthetic small molecule with antineoplastic properties. SB-715992 selectively inhibits kinesin spindle protein (KSP), resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase, and cell death in tumor cells that overexpress KSP. (NCI05)
C38132	_12_Melanoma_Peptide	Antineoplastic_Vaccine	12 Melanoma Peptide Vaccine|12 Melanoma Peptide|12MP
C38133	_6_Helper_Peptide	Vaccine_Adjuvant	6 Helper Peptide|6HP
C38134	Tetanus_Helper_Peptide	Vaccine_Adjuvant	Tetanus Toxoid Helper Peptide|Tet	Obtained by genetic engineering from the bacterial Clostridium tetani toxoid, tetanus toxoid helper peptide QYIKANSKFIGITEL (amino acids 830-844) binds to class II MHC molecules as a nonspecific vaccine helper epitope (adjuvant) and induces an increased (and long term) immune response by increasing the helper T-cell response. (NCI05)
C38135	Anti-gp100_TCR_Retroviral_Vector-Transduced_Autologous_TIL	Biological_Agent	Anti-gp100 TCR Retroviral Vector-Transduced Autologous TIL	Human tumor infiltrating lymphocytes (TIL) isolated from a patient with melanoma and genetically modified ex vivo to react with the melanoma antigen gp100.  When transferred back to the patient, recognition of gp100-expressing melanoma cells by these genetically modified tumor-infiltrating lymphocytes may result in tumor regression. (NCI04)
C38136	Anti-gp100_TCR_Retroviral_Vector-Transduced_Autologous_PBL	Biological_Agent	Anti-gp100 TCR Retroviral Vector-Transduced Autologous PBL	Human peripheral blood lymphocytes (PBL) isolated from a patient with melanoma and genetically modified ex vivo to react with the melanoma antigen gp100. These genetically modified PBL are stimulated with gp1000 and then transferred back to the patient to migrate to and kill gp100-expressing melanoma cells. (NCI04)
C38137	Anti-MART-1_TCR_Retroviral_Vector-Transduced_Autologous_TIL	Biological_Agent	Anti-MART-1 TCR Retroviral Vector-Transduced Autologous TIL	Human tumor infiltrating lymphocytes (TIL) isolated from a patient with melanoma and genetically modified ex vivo to react with the melanoma antigen MART.  These genetically modified TIL are stimulated with MART and then transferred back to the patient to migrate to and kill MART-expressing melanoma cells. (NCI04)
C38138	Ferumoxytol	Contrast_Agent	Ferumoxytol	A superparamagnetic iron oxide nanoparticle coated with a low molecular weight semi-synthetic carbohydrate, polyglucose sorbitol carboxymethyl ether, with potential anti-anemic and imaging properties. After intravenous administration, ferumoxytol replaces iron stores with fewer side effects compared to the use of oral iron.  In addition, this agent generates T1 relaxation, producing a magnetic field and enhancing T2 relaxation, thereby darkening contrast media-containing structures in magnetic resonance imaging (MRI). Due to small particle size, ferumoxytol remains in the intravasculature for a prolonged period and so may be used as a blood pool agent. (NCI05)
C38139	Talampanel	Anticonvulsant_Agent	Talampanel|GYKI-53773	A synthetic derivative of dioxolo-benzodiazepine with anti-seizure activity.  Talampanel noncompetitively binds to the AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) subtype of glutamate excitatory amino acid receptors and may inhibit the growth of gliomas by interfering with neurotransmitters involved in brain tumor growth. This agent may also protect against traumatic brain injury. (NCI04)
C38140	Ferumoxtran-10	Contrast_Agent	Ferumoxtran-10|Combidex	A synthetic ultrasmall superparamagnetic iron oxide composed of dextran-coated iron oxide nanoparticles (also known as 'ultrasmall particulate iron oxides' or USPIO). Ferumoxtran-10, which accumulates in non-cancerous lymphatic tissue, is used as a molecular resonance imaging (MRI) contrast agent. (NCI04)
C38141	Pneumococcal_7-Valent_Conjugate_Vaccine	Conjugate_Vaccine	Pneumococcal 7-Valent Conjugate Vaccine|Prevnar	An active immunizing agent used to prevent infection by the bacterium Streptococcus pneumoniae.  Pneumococcal 7-valent conjugate vaccine consists of a solution of saccharides of the capsular antigens of Streptococcus serotypes 4, 6B, 9V, 14, 18C, 19F, and 23F individually conjugated to diphtheria CRM 197 protein. (NCI04)
C38142	_17-Dimethylaminoethylamino_17-Demethoxygeldanamycin	Geldanamycin_Analogue	17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin|17-DMAG	An analogue of the benzoquinone antineoplastic antibiotic geldanamycin.  17-(Dimethylaminoethylamino)-17-Demethoxygeldanamycin binds to HSP90, a chaperone protein that aids in the assembly, maturation and folding of proteins.  Subsequently, the function of Hsp90 is inhibited, leading to the degradation and depletion of its client proteins such as kinases and transcription factors involved with cell cycle regulation and signal transduction.  (NCI04)
C38143	Recombinant_NY-ESO-1_Protein	Vaccine_Antigen	Recombinant NY-ESO-1 Protein	A genetically engineered synthetic protein, Recombinant NY-ESO-1 Protein (Cancer-Testis Tumor Antigen Family) elicits strong humoral and cellular immune responses to NY-ESO-1-expressing cancers and is used to produce specific vaccines to increase the immune response against tumors. NY-ESO-1 epitopes presented by human HLA are recognized by CD4(+) T lymphocytes in patients with NY-ESO-1-expressing melanoma. (NCI04)
C38144	Lansky_Play-Performance_Status	Performance_Status	Lansky Play-Performance Status|L|Lansky|Lansky Play Score|Lansky Play-Performance Scale	The play-performance scale for children is a parent-rated instrument which records usual play activity as the index of performance.  It is similar to the Karnofsky Performance Scale for adults.
C38145	Chronic_Allograft_Nephropathy	Focal_Segmental_Glomerulosclerosis|Transplant-Related_Disorder	Chronic Allograft Nephropathy|CAN
C38146	Chronic_Allograft_Arteriopathy	Arterial_Disorder|Transplant-Related_Disorder	Chronic Allograft Arteriopathy
C38147	Ind-2	Business_Rules	Ind-2	A caDSR representation term that is used to indicate a question with permissible values of yes/no.
C38148	Ind-3	Business_Rules	Ind-3	A caDSR representation term that is used to indicate a question with permissible values of yes/no/unknown.
C38149	Antiparkinsonian_Agent	Adjuvant	Antiparkinsonian Agent
C38150	Neoplasm_with_Perivascular_Epithelioid_Cell_Differentiation	Perivascular_Neoplasm	Neoplasm with Perivascular Epithelioid Cell Differentiation|PEComa
C38151	Epithelioid_Type_Angiomyolipoma	Angiomyolipoma	Epithelioid Type Angiomyolipoma
C38152	Clear_Cell-Sugar-Tumor_of_the_Lung	Benign_Lung_Neoplasm|Lung_Soft_Tissue_Neoplasm|Neoplasm_with_Perivascular_Epithelioid_Cell_Differentiation	Lung Clear Cell Tumor|Clear Cell-Sugar-Tumor of the Lung|Sugar Tumor	A rare benign mesenchymal lung tumor arising from perivascular cells with epithelioid differentiation.  It is composed of round or oval cells with abundant clear or eosinophilic cytoplasm and distinct cell borders.  The vast majority of patients are asymptomatic and the tumors are discovered incidentally.  Excision is curative.
C38153	Lung_Lymphangioleiomyomatosis	Lung_Soft_Tissue_Neoplasm|Lymphangiomyomatosis	Lung Lymphangioleiomyomatosis|Lung Lymphangiomyomatosis
C38154	Clear_Cell_Myomelanocytic_Tumor_of_the_Falciform_Ligament_Ligamentum_Teres	Neoplasm_with_Perivascular_Epithelioid_Cell_Differentiation	Clear Cell Myomelanocytic Tumor of the Falciform Ligament/Ligamentum Teres	A very rare, usually benign neoplasm with perivascular epithelioid cell differentiation characterized by the presence of clear spindle cells arranged in fascicles and nests that usually affects young girls.  Patients usually present with a painful abdominal mass.
C38155	Recurrent_Disease	Clinical_Course_of_Disease	Recurrent Disease|Relapsed Disease	The return of a disease after a remission.
C38156	Metachronous_Malignant_Neoplasm	Malignant_Neoplasm	Metachronous Malignant Neoplasm	A malignant tumor that arises at a site separate from another, primary malignant tumor in the same anatomic system.  It is not clear if metachronous malignant neoplasms represent new primary tumors or metastatic disease.  Examples include metachronous osteosarcoma of the bones that develops in patients with known primary bone osteosarcoma, and metachronous Wilms' tumor that affects the opposite kidney in patients with a history of Wilms' tumor.
C38157	Metachronous_Osteosarcoma	Metachronous_Malignant_Neoplasm|Osteosarcoma	Metachronous Osteosarcoma|Metachronous Osteosarcoma of the Bone
C38158	Metachronous_Wilms_Tumor	Metachronous_Malignant_Neoplasm|Renal_Wilms_Tumor	Metachronous Wilms' Tumor|Metachronous Wilms Tumor of the Kidney
C38159	Plasmablastic_Lymphoma_of_Mucosa_Site	Plasmablastic_Lymphoma	Plasmablastic Lymphoma of Mucosa Site
C38160	AIDS-Related_Plasmablastic_Lymphoma_of_Mucosa_Site	AIDS-Related_Plasmablastic_Lymphoma|Plasmablastic_Lymphoma_of_Mucosa_Site	AIDS-Related Plasmablastic Lymphoma of Mucosa Site
C38161	Gastrointestinal_Non-Hodgkin_s_Lymphoma	Gastrointestinal_Lymphoma|Non-Hodgkin_s_Lymphoma	Gastrointestinal Non-Hodgkin's Lymphoma|Primary Gastrointestinal Non-Hodgkin's Lymphoma
C38162	Gastrointestinal_Lymphoma	Lymphoma_by_Site|Malignant_Gastrointestinal_Neoplasm	Gastrointestinal Lymphoma|Primary Gastrointestinal Lymphoma
C38163	Gastrointestinal_Hodgkin_s_Lymphoma	Gastrointestinal_Lymphoma|Hodgkin_s_Lymphoma	Gastrointestinal Hodgkin's Lymphoma|Gastrointestinal Hodgkin Lymphoma|Primary Gastrointestinal Hodgkin's Lymphoma
C38164	Male_Reproductive_System_Precancerous_Condition	Male_Reproductive_System_Neoplasm|Precancerous_Condition_by_Site	Male Reproductive System Precancerous Condition
C38165	Therapeutic_Urokinase	Anticoagulant_Agent	Recombinant Urokinase|Abbokinase|Breokinase|Urinary Plasminogen Activator|Urokinase|Urokinase Plasminogen Activator|Urokinase-Type Plasminogen Activator|urokinase	A drug that dissolves blood clots or prevents them from forming.
C38166	Outer	General_Modifier	Outer	Outer; being on or toward the outside of the body.
C38167	CD10_Messenger_RNA_Overexpression	Messenger_RNA_Overexpression	CD10 Messenger RNA Overexpression|CD10 mRNA Overexpression|MME Gene mRNA Overexpression
C38168	BCL-6_Messenger_RNA_Overexpression	Messenger_RNA_Overexpression	BCL-6 Messenger RNA Overexpression|BCL-6 mRNA Overexpression
C38169	A-myb_Messenger_RNA_Overexpression	Messenger_RNA_Overexpression	A-myb Messenger RNA Overexpression|A-myb mRNA Overexpression
C38170	LMO2_Messenger_RNA_Overexpression	Messenger_RNA_Overexpression	LMO2 Messenger RNA Overexpression|LMO2 mRNA Overexpression
C38171	PKCbeta1_Messenger_RNA_Overexpression	Messenger_RNA_Overexpression	PKCbeta1 Messenger RNA Overexpression|PKCbeta1 mRNA Overexpression
C38172	Cyclin_D2_Messenger_RNA_Overexpression	Messenger_RNA_Overexpression	Cyclin D2 Messenger RNA Overexpression|Cyclin D2 mRNA Overexpression
C38173	BCL-2_Messenger_RNA_Overexpression	Messenger_RNA_Overexpression	BCL2 Gene mRNA Overexpression|BCL-2 Messenger RNA Overexpression|BCL-2 mRNA Overexpression
C38174	IRF4_MUM1_Messenger_RNA_Overexpression	Messenger_RNA_Overexpression	IRF4/MUM1 Messenger RNA Overexpression|IRF4 Gene mRNA Overexpression|IRF4/MUM1 mRNA Overexpression
C38175	CD44_Messenger_RNA_Overexpression	Messenger_RNA_Overexpression	CD44 Messenger RNA Overexpression|CD44 mRNA Overexpression
C38176	BCL-2_Translocation	Gene_Abnormality	BCL2 Gene Translocation|BCL-2 Translocation
C38177	APRT_Gene	Glycosyltransferase_Gene	APRT Gene|AMP|APRT|Adenine Phosphoribosyltransferase Gene	Human APRT Gene (Purine/Pyrimidine Phosphoribosyltransferase Family) encodes 179-aa 19-kDa homodimeric cytoplasmic Adenine Phosphoribosyltransferase, involved in an AMP purine salvage reaction that recycles adenine into nucleic acids by formation of AMP from adenine and 5-phosphoribosyl-1-pyrophosphate (PRPP). Defects in APRT cause APRT deficiency. (NCI)
C38178	POMC_Gene	Peptide_Hormone_Gene	POMC Gene|ACTH|CLIP|MSH|POC|POMC|Proopiomelanocortin (Adrenocorticotropin/ Beta-Lipotropin/ Alpha-Melanocyte Stimulating Hormone/ Beta-Melanocyte Stimulating Hormone/ Beta-Endorphin) Gene	Human POMC Gene (POMC Family) encodes NPP, MSHs, Beta-Endorphin, Met-Enkephalin, Lipotropins, Corticotropin-Like Intermediary Peptide, and Adrenocorticotropic Hormone. Specific enzymatic cleavages of a 267-aa 29-kDa (precursor) precursor at paired basic residues yield different active peptides. Secreted by the anterior pituitary gland, ACTH stimulates adrenal release of cortisol. (NCI)
C38179	GC_Gene	Transport_Protein_Gene	GC Gene|DBP|GC|Group-Specific Component (Vitamin D Binding Protein) Gene|VDBG|VDBP	Human GC Gene (ALB/AFP/VDB Family) encodes secreted 474-aa 53-kDa (precursor) Alpha-Globulin, a multifunctional plasma globulin protein containing 3 albumin domains also found in cerebrospinal fluid, urine, and on many cell surfaces. Alpha-Globulin transports vitamin D sterols in plasma to target tissues and associates with membrane-bound B-lymphocyte surface immunoglobulin and with IgG Fc receptors on T-lymphocyte membranes. Alpha-Globulin also prevents actin polymerization by binding monomers. (NCI)
C38181	_9q21	Chromosome_Band	9q21	A chromosome band present on 9q
C38182	_18q21_1-q21_32	Chromosome_Band	18q21.1-q21.32	A chromosome band present on 18q
C38183	_4q28_2-q31_1	Chromosome_Band	4q28.2-q31.1	A chromosome band present on 4q
C38184	ALK_Gene	Receptor_Tyrosine_Kinase_Gene	ALK Gene|ALK|Anaplastic Lymphoma Kinase (Ki-1) Gene	Expressed in CNS, small intestine, and testis, human ALK Gene (INSR/Tyr Kinase Family) encodes N-glycosylated 1620-aa 176-kDa (precursor) Anaplastic Lymphoma Kinase, a type I membrane protein orphan receptor protein-tyrosine kinase with greatest sequence similarity to LTK and containing an LDL-receptor class A domain and 2 MAM domains that plays an important role in development and function of the nervous system, effecting specific neurons. Chromosomal translocation (2;5) associated with some ALCLs creates an oncogenic fusion of 3' ALK and 5' NPM. (NCI)
C38185	AGT_Gene	Peptide_Hormone_Gene	AGT Gene|AGT|ANHU|Angiotensinogen (Serine (Or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 8) Gene|SERPINA8	Expressed in liver, human AGT Gene (Serpin Family) encodes secreted 485-aa 53-kDa (precursor) Angiotensinogen. In response to lowered blood pressure, renin cleaves Angiotensinogen to inactive Angiotensin I decapeptide, cleaved by ACE to generate physiologically active vasopressor Angiotensin II octapeptide, which maintains blood pressure and regulates the volume and mineral balance of body fluids. Angiotensin II is cleaved to Angiotensin III heptapeptide, an aldosterone stimulant. AGT variations may be associated with predisposition to or pathogenesis of essential hypertension, as well as preeclampsia. (NCI)
C38186	Clinical_or_Research_Facility	NCI_Administrative_Concepts	Clinical or Research Facility
C38187	Neuropeptide_Gene	Gene	Neuropeptide Gene	Genes which encode peptides that are released by both neurons and non-neuronal cells. Protein products of neuropeptide genes are intracellular messengers that function as neurotransmitters or hormones
C38188	KNG_Gene	Neuropeptide_Gene	KNG1 Gene|KNG|KNG Gene|KNG1|Kininogen 1 Gene	Human KNG Gene encodes secreted Bradykinin, an active nonapeptide kinin and neuropeptide enzymatically released in the blood from Kininogen, containing cystatin-like domains, by plasma kallikrein that has diverse physiological effects: smooth muscle contraction, hypotension, vasodilation, increased vascular permeability, natriuresis and diuresis, decreased blood glucose levels, mediation of inflammation, nociceptor stimulation, release of inflammatory prostaglandin mediators from damaged tissues, and cardioprotection. (NCI)
C38189	CALCA_Gene	Peptide_Hormone_Gene	CALCA Gene|CALC1|CALCA|CGRP|CGRP-I|CGRP1|CT|Calcitonin/Calcitonin-Related Polypeptide, Alpha Gene|KC	The 6.5-kb 6-exon human CALCA Gene (Calcitonin Family) encodes within a single mRNA multiple 32-aa 3.4-kD secreted Calcitonin hormone polypeptides (exon 4) cleaved from a large polyprotein precursor synthesized by thyroid parafollicular 'C' cells. Alternative processing results in production of a neural (hypothalamus) CGRP mRNA distinct from the thyroidal mRNA that encodes Calcitonin Gene-Related Peptide (exon 5). Opposite to the effect of PTH, Calcitonin induces a rapid drop in blood calcium and phosphate level by promoting bone incorporation. (NCI)
C38190	CRH_Gene	Peptide_Hormone_Gene	CRH Gene|CRF|CRH|Corticotropin Releasing Hormone Gene	Expressed in the hypothalamic paraventricular nucleus in response to stress, in placenta, and in peripheral tissues, human CRH Gene (Sauvagine/CRH/Urotensin I Family) encodes secreted 41-aa peptide Corticotropin Releasing Hormone, derived from a 196-aa 21-kDa preprohormone, that regulates release of corticotropin from pituitary gland. A rapid increase in circulating CRH occurs at the onset of parturition. (NCI)
C38191	CD36_Gene	Receptor_Gene	CD36 Gene|CD36|CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor) Gene|FAT|GP3B|GP4|GPIV|SCARB3	Human CD36 Gene (CD36 Family) encodes 471-aa 53-kDa CSVTCG-Specific TSP-1 Receptor, an integral membrane protein that binds to collagen, thrombospondin, anionic phospholipids, long chain fatty acids, and oxidized LDL. A thrombospondin and collagen receptor in platelets, CD36 may regulate fatty acid transport, binds Cys-Ser-Val-Thr-Cys-Gly (CSVTCG), and functions in widely distributed TSP-mediated cell adhesion. TSP-1 up-regulates MMP-9 expression through CD36, which mediates macrophage scavenging of apoptotic polymorphonuclear cells. Defects in CD36 cause platelet glycoprotein IV deficiency. (NCI)
C38192	Auricular_Route_of_Drug_Administration	Drug_Route_of_Administration	Auricular Route of Administration|AURICULAR (OTIC)|Auricular|OTIC|Otic	Administration of the drug to or by way of the ear. The drug action is mostly topical/local.
C38193	Buccal_Route_of_Drug_Administration	Oral_Route_of_Drug_administration	Buccal Route of Administration|BUCC|BUCCAL|Buccal	Administration directed toward the cheek, generally from within the mouth.
C38194	Conjunctival_Route_of_Drug_Administration	Ophthalmic_Route_of_Drug_Administration	Conjunctival Route of Administration|CONJUNC|CONJUNCTIVAL|Conjunctival	Administration of a drug to the conjunctiva, the most frequently used mode of ocular drug delivery. Advantages of this topical route include direct, localized delivery to the target tissue, good accessibility into the intraocular environment owing to membrane permeability and large intercellular spaces, avoidance of hepatic first-pass metabolism, convenience, and relative painlessness. Limitations include rapid drug elimination due to lacrimation and nasolacrimal drainage, drug binding to, and metabolism by, tear proteins, and target non-specificity as a result of systemic absorption through the nasal mucosa and conjunctival vasculature.
C38195	KRT19_Gene	Intermediate_Filament_Gene	KRT19 Gene|CK19|K19|K1CS|KRT19|Keratin 19 Gene	Human KRT19 Gene (Intermediate Filament/Keratin Family) encodes 400-aa 44-kDa Cytokeratin 19, a type I cytoskeletal intermediate filament subunit with an alpha-helical central domain that conforms to the canonical keratin structure and lacking the C-terminal non-helical Keratin tail domain, unlike all other IF proteins. Responsible for the structural integrity of epithelial cells, type I acidic (40-55-kDa) and type II basic/neutral (56-70-kDa) cytokeratins are coordinately expressed and arranged in heterotetrameric I/II keratin chains. The smallest known acidic cytokeratin, KRT19 is not paired with a basic cytokeratin in epithelial cells and is specifically expressed in the periderm that transiently envelopes the developing epidermis. (NCI)
C38196	Continuous_Intravenous_Infusion	Intravenous_Infusion	Continuous Intravenous Infusion|CIV	A route of administration of a fluid drug form into a vein or veins, over a time duration of equal to or more than 24 hours. Method allows to maintain steady state plasma/serum medication levels, a smaller total daily dose of drug to achieve the same pharmacodynamic endpoint in comparison with intermittent or bolus infusion, and may result in lower toxicity. The method has a positive impact on health-care costs.
C38197	Dental_Route_of_Drug_Administration	Drug_Route_of_Administration	Dental Route of Administration|DENT|DENTAL|Dental	Administration of the drug to a tooth or teeth.
C38198	Drug_Administration_into_Soft_Tissue	Parenteral_Route_of_Drug_Administration	Soft Tissue Route Of Administration|SOFT TIS|SOFT TISSUE|Soft Tissue	Administration into any soft tissue.
C38199	Drug_Administration_via_Gastrostomy	Intragastric_Route_of_Drug_Administration	Administration via Gastrostomy|G-TUBE|Gastrostomy	Drug administration through a gastric fistula or a surgically created artificial opening into the stomach through the abdominal wall with insertion of a tube.
C38200	Drug_Administration_via_Hemodialysis	Parenteral_Route_of_Drug_Administration	Administration Via Hemodialysis|HEMO|HEMODIALYSIS	Administration through hemodialysate fluid.
C38201	Drug_Administration_via_Implantation	Parenteral_Route_of_Drug_Administration	Administration via Implantation|Implant|Implantation	Drug administration via imbedded implants used as depot formulations to limit high drug concentrations to the area surrounding the pathology or to provide sustained drug release for systemic therapy. Implant systems are used when chronic therapy is indicated and may take the form of highly viscous liquids, semi-solid formulations, rod impregnated with drug substances, or a liquid which gels in situ. Release kinetics may be controlled by varying polymer composition, different types of stimuli, such as electrical, and varying of implant structure, e.g. as coating.
C38202	Drug_Administration_via_Jejunostomy	Enteral_Route_of_Drug_Administration	Administration via Jejunostomy|J-Tube|Jejunostomy	Administration of a drug through a surgical opening between the jejunum and the surface of the abdominal wall.
C38203	Drug_Iontophoresis	Drug_Route_of_Administration	Iontophoresis Route of Administration|ION|IONTOPHORESIS|Iontophoresis	Administration by means of an electric current where ions of soluble salts migrate into the tissues of the body.
C38205	Endocervical_Route_of_Drug_Administration	Intracavitary_Route_of_Drug_Administration	Endocervical Route of Administration|E-CERVIC|EC|ENDOCERVICAL|Endocervical|Intracervical Route of Administration	Administration of the drug within the canal of the cervix uteri.
C38206	Endosinusial_Route_of_Drug_Administration	Intrasinal_Route_of_Drug_Administration	Endosinusial Route of Administration|E-SINUS|ENDOSINUSIAL|ES|Endosinusial	Administration of the drug within the nasal sinuses.
C38207	Endothoracic_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Endothoracic Route of Administration|I-THORAC|INTRATHORACIC|Intrathoracic|Intrathoracic Route of Administration	Administration of a drug within the thorax (internal to the ribs).
C38208	Endotracheal_Route_of_Drug_Administration	Drug_Route_of_Administration	Endotracheal Route of Administration|E-TRACHE|ENDOTRACHEAL|ET|Endotracheal|I-TRACHE|INTRATRACHEAL|Intratracheal|Intratracheal Route of Administration	Administration directly into the trachea. Synonymous with the term intratracheal.
C38209	Enteral_Route_of_Drug_Administration	Drug_Route_of_Administration	Enteral Route of Administration|ENTER|ENTERAL|Enteral	Administration directly into the intestines.
C38210	Epidural_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Epidural Route of Administration|EPIDUR|EPIDURAL|Epidural	Administration of the drug in the epidural space, usually at the lumbar level of the spine. The drug must initially cross the dura mater before exerting its effect on the nervous system components. The drug is also subject to uptake into the rich epidural plexus of veins. Uptake and distribution after epidural administration resembles that seen after intramuscular injection. The portion of drug that is not taken into the vascular compartment is available to cross the dura. Hydrophilicity is a major component in the pharmacokinetics of drug transfer into the subdural space.
C38211	Extraamniotic_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Extraamniotic Route of Administration|EXTRA-AMNIOTIC|Extra-Amniotic|X-AMNI	Administration of the drug to the outside of the membrane enveloping the fetus.
C38212	Extracorporeal_Circulation_Route_of_Drug_Administration	Drug_Route_of_Administration	Extracorporeal Circulation Route of Administration|EXTRACORPOREAL|Extracorporeal|X-CORPOR	Administration outside of the body.
C38213	Extraluminal_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Extraluminal Route of Administration|Extraluminal|X-LUMIN	Administration of the agent involving the passage of an inflatable catheter outside the lumen of a blood vessel. The effects of the drug are prolonged when administered extra-luminary, potentially due to absorption in the perivascular fat-pad and subsequent slow release.
C38214	Genitourinary_Route_of_Drug_Administration	Drug_Route_of_Administration	Genitourinary Route of Administration|GU|Genitourinary	Route of drug administration through the irrigation of organs pertaining to the genital and urinary systems.
C38215	Infiltration_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Infiltration Route of Administration|INFIL|INFILTRATION|Infiltration	Administration that results in substances passing into tissue spaces or into cells.
C38216	Inhalation_Route_of_Drug_Administration	Drug_Route_of_Administration	Inhalation Route of Administration|INH|Inhalation|RESPIR|RESPIRATORY (INHALATION)	Administration of a substance in the form of a gas, aerosol, or fine powder via the respiratory tract, usually by oral or nasal inhalation, for local or systemic effect.
C38217	Intracoronal_Dental_Route_of_Drug_Administration	Dental_Route_of_Drug_Administration	Intracoronal Dental Route of Administration|I-CORONAL|INTRACORONAL, DENTAL|Intracoronal, Dental	Administration of a drug within a crown of tooth.
C38218	Intracoronary_Route_of_Drug_Administration	Intraarterial_Route_of_Drug_Administration	Intracoronary Route of Administration|I-CORONARY|INTRACORONARY|Intracoronary	Administration of a drug within the coronary arteries supplying blood to the tissues of the heart.
C38219	Interstitial_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Interstitial Route of Administration|INTERSTIT|INTERSTITIAL|Interstitial	Administration to or in the interstices of a tissue.
C38220	Intraabdominal_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intraabdominal Route of Administration|I-ABDOM|INTRA-ABDOMINAL|Intra-Abdominal	Administration of the drug within the abdominal cavity, typically as a loco-regional therapy for disease confined to the abdomen.
C38221	Intraamniotic_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intraamniotic Route of Administration|I-AMNI|INTRA-AMNIOTIC|Intra-Amniotic	Administration of the drug within the amnion.
C38222	Intraarterial_Route_of_Drug_Administration	Intravascular_Route_of_Drug_Administration	Intraarterial Route of Administration|I-ARTER|I-arter|IA|INTRA-ARTERIAL|Intra-Arterial Route of Administration|Intraarterial Infusion|Intraarterial Injection	Administration within an artery or arteries.
C38223	Intraarticular_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intraarticular Route of Administration|I-ARTIC|INTRA-ARTICULAR|Intra-Articular	Administration of the drug within a joint.
C38224	Intrabiliary_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intrabiliary Route of Administration|I-BILI|INTRABILIARY|Intrabiliary	Administration within the bile, bile ducts or gallbladder.
C38225	Intrabronchial_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intrabronchial Route of Administration|I-BRONCHI|INTRABRONCHIAL|Intrabronchial	Administration of a drug within a bronchus or bronchi. The intrabronchial drug delivery can be used for both local and systemic drug action.
C38226	Intrabursal_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intrabursal Route of Administration|I-BURSAL|INTRABURSAL|Intrabursal	Administration of a drug within a bursal cavity.
C38227	Intracardiac_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intracardiac Route of Administration|I-CARDI|INTRACARDIAC|Intracardiac	Administration of a drug within the heart. Concept refers both to administration into myocardium and within a chamber of the heart.
C38228	Intracartilaginous_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intracartilaginous Route of Administration|I-CARTIL|INTRACARTILAGINOUS|Intracartilaginous	Administration of a drug within a cartilage.
C38229	Intracaudal_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intracaudal Route of Administration|I-CAUDAL|INTRACAUDAL|Intracaudal	Administration of a drug within the cauda equina.
C38230	Intracavernous_Route_of_Drug_Administration	Drug_Route_of_Administration	Intracavernous Route of Administration|I-CAVERN|INTRACAVERNOUS|Intracavernous	Administration of a drug within a pathologic cavity.
C38231	Intracavitary_Route_of_Drug_Administration	Drug_Route_of_Administration	Intracavitary Route of Administration|I-CAVIT|INTRACAVITARY|Intracavitary	Administration of a drug within any natural, non-pathologic cavity, such as that of cervix, uterus, or penis.
C38232	Intracerebral_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intracerebral Route of Administration|I-CERE|INTRACEREBRAL|Intracerebral	Administration of a drug within the cerebrum, directly into brain tissue, usually by injection or direct application.
C38233	Intracisternal_Route_of_Drug_Administration	Intracerebral_Route_of_Drug_Administration	Intracisternal Route of Administration|I-CISTERN|INTRACISTERNAL|Intracisternal	Administration within the cisterna magna cerebellomedularis.
C38234	Intracorneal_Route_of_Drug_Administration	Ophthalmic_Route_of_Drug_Administration|Parenteral_Route_of_Drug_Administration	Intracorneal Route of Administration|I-CORNE|INTRACORNEAL|Intracorneal	Administration of a drug within the eye cornea.
C38235	Intracorporus_Cavernosum_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intracorporus Cavernosum Route of Administration|I-CORPOR|INTRACORPORUS CAVERNOSUM|Intracorporus Cavernosum	Administration of a drug within the dilatable venous spaces of the cavernous tissue of the penis.
C38236	Intracranial_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intracranial Route of Administration|I-CRAN|Intracranial	Administration of a drug within the skull.
C38238	Intradermal_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intradermal Route of Administration|DL|I-DERMAL|I-dermal|IC|ID|INTRADERMAL|Intracutaneous|Intradermal|Intradermal Injection	Administration within the dermis.
C38239	Intradiscal_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intradiscal Route of Administration|I-DISCAL|INTRADISCAL|Intradiscal	Administration of a drug within a fibrocartilaginous intervertebral disc.
C38240	Intraductal_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intraductal Route of Administration|I-DUCTAL|INTRADUCTAL|Intraductal	Administration of a drug within the duct of a gland.
C38241	Intraduodenal_Route_of_Drug_Administration	Enteral_Route_of_Drug_Administration	Intraduodenal Route of Administration|I-DUOD|INTRADUODENAL|Intraduodenal	Administration of a drug within the duodenum.
C38242	Intradural_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intradural Route of Administration|I-DURAL|INTRADURAL|Intradural	Administration of a drug within or beneath the dura mater.
C38243	Intraepidermal_Route_of_Drug_Administration	Intraepithelial_Route_of_Drug_Administration	Intraepidermal Route of Administration|I-EPIDERM|INTRAEPIDERMAL|Intraepidermal	Administration of a drug within the superficial epithelial layer of the skin.
C38244	Intraepithelial_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intraepithelial Route of Administration|IEL|Intraepithelial	Administration of a drug within the cellular avascular layer covering internal and external surfaces of the body, its parts, organs, and cavities.
C38245	Intraesophageal_Route_of_Drug_Administration	Enteral_Route_of_Drug_Administration	Intraesophageal Route of Administration|I-ESO|INTRAESOPHAGEAL|Intraesophageal	Administration of a drug within the esophagus.
C38246	Intragastric_Route_of_Drug_Administration	Enteral_Route_of_Drug_Administration	Intragastric Route of Administration|I-GASTRIC|INTRAGASTRIC|Intragastric	Administration of a drug within the stomach, e.g. via gavage or via gastrostomy.
C38247	Intragingival_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intragingival Route of Administration|I-GINGIV|INTRAGINGIVAL|Intragingival	Administration of a drug within the gingivae.
C38248	Intrahepatic_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intrahepatic Route of Administration|IH|Intrahepatic	Intrahepatic route of drug administration is a method of drug delivery within the liver, predominantly via hepatic vein or artery. Regimen might be more beneficial then systemic one by delivering a higher dose of drug to the liver and reducing overall systemic exposure.
C38249	Intraileal_Route_of_Drug_Administration	Enteral_Route_of_Drug_Administration	Intraileal Route of Administration|I-ILE|INTRAILEAL|Intraileal	Administration of a drug within the distal portion of the small intestine, from the jejunum to the cecum.
C38250	Intralesional_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intralesional Route of Administration|I-LESION|INTRALESIONAL|Intralesional	Administration of a drug within or introduced directly into a localized lesion. Method allows to achieve high concentration of the agent in the lesion and delay drug release in systemic circulation.
C38251	Intraluminal_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intraluminal Route of Administration|I-LUMIN|INTRALUMINAL|Intraluminal	Administration of a drug within the cavity or channel of a tubular structure or tubular organ.
C38252	Intralymphatic_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intralymphatic Route of Administration|I-LYMPHAT|INTRALYMPHATIC|Intralymphatic	Administration of a drug within the lymphatic system: into the lymph nodes or/and the lymph vessels.
C38253	Intramedullary_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intramedullary Route of Administration|I-MEDUL|INTRAMEDULLARY|Intramedullary	Administration of a drug within the marrow cavity of a bone. The essential premise for intraosseous administration is a functioning medullary cavity. The route is considered reasonably safe and permits rapid achievement of satisfactory plasma concentrations of therapeutic agent. The route is used for blood transfusion or fluid therapy when other routes are awkward, as in neonates.
C38254	Intrameningeal_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intrameningeal Route of Administration|I-MENIN|INTRAMENINGEAL|Intrameningeal	Administration within the meninges (the three membranes that envelope the brain and spinal cord).
C38255	Intraocular_Route_of_Drug_Administration	Ophthalmic_Route_of_Drug_Administration|Parenteral_Route_of_Drug_Administration	Intraocular Route of Administration|I-OCUL|INTRAOCULAR|Intraocular	Administration of a drug within the eye. Intraocular drugs are almost always used for their local effects.
C38256	Intraovarian_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intraovarian Route of Administration|I-OVAR|INTRAOVARIAN|Intraovarian	Administration of a drug within the ovary or ovaries.
C38257	Intrapericardial_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intrapericardial Route of Administration|I-PERICARD|INTRAPERICARDIAL|Intrapericardial	Administration of a drug within the pericardium. Intrapericardial application of therapeutic agents provides a strategy for site-specific treatment of heart or coronary diseases. The magnitude of the local advantage depends on substance exchange between the local and the blood compartments and on substance elimination from these compartments.
C38258	Intraperitoneal_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intraperitoneal Route of Administration|I-PERITON|INTRAPERITONEAL|IP|Intraperitoneal|Intraperitoneal Infusion|intraperitoneal infusion	A method of delivering fluids and drugs directly into the abdominal cavity through a thin tube.
C38259	Intrapleural_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intrapleural Route of Administration|I-PLEURAL|INTRAPLEURAL|Intrapleural	Administration of a drug within the pleural cavity. The intrapleural drug administration usually results in both local and systemic drug action.
C38260	Intraprostatic_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intraprostatic Route of Administration|I-PROSTAT|INTRAPROSTATIC|Intraprostatic	Administration of a drug within the prostate gland.
C38261	Intrapulmonary_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intrapulmonary Route of Administration|I-PULMON|INTRAPULMONARY|Intrapulmonary	Administration of a substance in the form gas, aerosol, emulsion, or liquid (during partial and tidal liquid ventilation), or fine powder into the lung, often with systemic action. Method limitations: insufficient drug delivery to peripheral lung regions, the inability to quantify the actually administered dose, and non-homogeneous distribution.
C38262	Intrasinal_Route_of_Drug_Administration	Nasal_Route_of_Drug_Administration	Intrasinal Route of Administration|I-SINAL|INTRASINAL|Intrasinal	Administration within the nasal or periorbital sinuses.
C38263	Intraspinal_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intraspinal Route of Administration|I-SPINAL|INTRASPINAL|Intraspinal	Administration within the vertebral column.
C38264	Intrasynovial_Route_of_Drug_Administration	Intraarticular_Route_of_Drug_Administration	Intrasynovial Route of Administration|I-SYNOV|INTRASYNOVIAL|Intrasynovial	Administration within the synovial cavity of a joint.
C38265	Intratendinous_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intratendinous Route of Administration|I-TENDIN|INTRATENDINOUS|Intratendinous	Administration within a tendon.
C38266	Intratesticular_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intratesticular Route of Administration|I-TESTIC|INTRATESTICULAR|Intratesticular	Administration within the testicle.
C38267	Intrathecal_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intrathecal Route of Administration|INTRATHECAL|IT|Intrathecal	Administration of drugs directly into spinal subarachnoid space in the cerebrospinal fluid, at any level of the cerebrospinal axis, including injection into the cerebral ventricles, in order to bypass the blood-brain barrier and achieve local, rapid effects on the meninges or cerebrospinal axis.
C38268	Intratubular_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intratubular Route of Administration|I-TUBUL|INTRATUBULAR|Intratubular	Administration within the tubules of an organ.
C38269	Intratumoral_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intratumoral Route of Administration|I-TUMOR|INTRATUMOR|Intratumor	Administration within a tumor.
C38270	Intratympanic_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intratympanic Route of Administration|I-TYMPAN|INTRATYMPANIC|Intratympanic	Administration within the auris media.
C38271	Intraurethral_Route_of_Drug_Administration	Drug_Route_of_Administration	Intraurethral Route of Administration|URETH|URETHRAL|Urethral|Urethral Route of Administration	Administration into the urethra.
C38272	Intrauterine_Route_of_Drug_Administration	Intracavitary_Route_of_Drug_Administration	Intrauterine Route of Administration|I-UTER|INTRAUTERINE|Intrauterine	Administration within the uterus.
C38273	Intravascular_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intravascular Route of Administration|I-VASC|INTRAVASCULAR|Intravascular	Administration within a vessel or vessels.
C38274	Intravenous_Bolus	Intravenous_Route_of_Drug_Administration	Intravenous Bolus|INTRAVENOUS BOLUS|IV BOLUS|IV Bolus|Intravenous Injection	Administration of a drug directly into circulation via a vein or veins over a time duration of less than or equal to 30 minutes. Method results in 100% bioavailability of the agent due to an absence of the absorption phase.
C38275	Intravenous_Infusion	Intravenous_Route_of_Drug_Administration	Intravenous Infusion|IVI	Introduction of a drug directly into venous circulation over the time duration of more than 30 minutes but less than 24 hours. Method results in 100% bioavailability of the agent due to an absence of the absorption phase and provides a precise and continuous mode of drug therapy, especially for drugs with a narrow therapeutic index. To achieve the steady state quickly, the loading dose is used. Intravenously administered drug is diluted in the pooled venous blood and pumped through lungs before entering systematic circulation (lung first-pass effect). The target organ receives only the fraction of drug corresponding to the fraction of received arterial blood.
C38276	Intravenous_Route_of_Drug_Administration	Intravascular_Route_of_Drug_Administration	Intravenous Route of Administration|INTRAVENOUS|IV|Intravenous	Administration of a drug within or into a vein or veins. Introduction of the drug directly into venous circulation results in 100% bioavailability due to an absence of the absorption phase, provides a precise and continuous mode of drug therapy, especially for drugs with a narrow therapeutic index.
C38277	Intraventricular_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Intraventricular Route of Drug Administration|I-VENTRIC|INTRAVENTRICULAR|Intraventricular|Intraventricular Route of Administration	Administration within a ventricle.
C38278	Intravesical_Route_of_Drug_Administration	Intracavitary_Route_of_Drug_Administration	Intravesical Route of Administration|I-VESIC|INTRAVESICAL|Intravesical	Administration within the bladder.
C38279	Intravenous_Drip	Intravenous_Route_of_Drug_Administration	Intravenous Drip|INTRAVENOUS DRIP|IV DRIP|IV Drip	Administration within or into a vein or veins over a sustained period of time.
C38280	Intravitreal_Route_of_Drug_Administration	Intraocular_Route_of_Drug_Administration	Intravitreal Route of Administration|I-VITRE|INTRAVITREAL|Intravitreal	Administration within the vitreous body of the eye.
C38281	Irrigation-Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration|Topical_Route_of_Drug_Administration	Irrigation-Route of Administration|IRRIG|IRRIGATION|Irrigation	Administration of a drug by bathing or flushing open wounds, body cavities or surfaces.
C38282	Laryngeal_Route_of_Drug_Administration	Drug_Route_of_Administration	Laryngeal Route of Administration|LARYN|LARYNGEAL|Laryngeal	Administration directly upon the larynx.
C38283	Mucosal_Route_of_Drug_Administration	Drug_Route_of_Administration	Mucosal Route of Administration|T-MUCOS|TRANSMUCOSAL|Transmucosal|Transmucosal Route of Administration	Administration across the mucosa.
C38284	Nasal_Route_of_Drug_Administration	Drug_Route_of_Administration	Nasal Route of Administration|NASAL|Nasal	Administration of a drug by the way of the nose. This often results in systemic action of the agent due to absorption through the nasal mucosa. The richly supplied vascular nature of the nasal mucosa coupled with its high drug permeation makes the nasal route of administration attractive for many drugs, including proteins and peptides.
C38285	Nasogastric_Route_of_Drug_Administration	Intragastric_Route_of_Drug_Administration	Nasogastric Route of Administration|NASOGASTRIC|NG|Nasogastric	Administration of a drug through the nose and into the stomach, usually by means of a tube.
C38286	Occlusive_Dressing_Technique	Topical_Route_of_Drug_Administration	Occlusive Dressing Technique|OCCLUS|OCCLUSIVE DRESSING TECHNIQUE	Administration by the topical route which is then covered by a dressing which occludes the area.
C38287	Ophthalmic_Route_of_Drug_Administration	Drug_Route_of_Administration	Ophthalmic Route of Administration|OPHTH|OPHTHALM|OPHTHALMIC|Ophthalmic	Administration of a drug to the external eye.
C38288	Oral_Route_of_Drug_administration	Drug_Route_of_Administration	Oral Route of Administration|ORAL|Oral|PO|Per Os	Administration to or by way of the mouth.
C38289	Oropharyngeal_Route_of_Drug_Administration	Oral_Route_of_Drug_administration	Oropharyngeal Route of Administration|ORO|OROPHARYNGEAL|Oropharyngeal	Administration directly to the mouth and pharynx..
C38290	Other_Routes_of_Drug_Administration	Drug_Route_of_Administration	Other Route of Administration|OTHER|Other	Administration is different from others on this list.
C38291	Parenteral_Route_of_Drug_Administration	Drug_Route_of_Administration	Parenteral Route of Administration|PAREN|PARENTERAL|Parenteral	Administration by injection, infusion, or implantation.
C38292	Periarticular_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Periarticular Route of Administration|P-ARTIC|PERIARTICULAR|Periarticular	Administration around a joint.
C38293	Perineural_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Perineural Route of Administration|P-NEURAL|PERINEURAL|Perineural	Administration of a substance within the tissues surrounding a nerve or nerves.
C38294	Periodontal_Route_of_Drug_Administration	Dental_Route_of_Drug_Administration	Periodontal Route of Administration|P-ODONT|PERIODONTAL|Periodontal	Administration around a tooth.
C38295	Rectal_Route_of_Drug_Administration	Drug_Route_of_Administration	Rectal Route of Administration|RECTAL|Rectal	Administration to the rectum.
C38296	Retrobulbar_Route_of_Drug_Administration	Ophthalmic_Route_of_Drug_Administration|Parenteral_Route_of_Drug_Administration	Retrobulbar Route of Administration|RETRO|RETROBULBAR|Retrobulbar	Administration behind the pons or behind the eyeball.
C38297	Subarachnoid_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Subarachnoid Route of Administration|S-ARACH|SUBARACHNOID|Subarachnoid	Administration beneath the arachnoid.
C38298	Subconjunctival_Route_of_Drug_Administration	Ophthalmic_Route_of_Drug_Administration	Subconjunctival Route of Administration|S-CONJUNC|SUBCONJUNCTIVAL|Subconjunctival	Administration beneath the conjunctiva.
C38299	Subcutaneous_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Subcutaneous Route of Administration|SC|SUBCUTANEOUS|Subcutaneous	Administration beneath the skin; hypodermic. Synonymous with the term SUBDERMAL.
C38300	Sublingual_Route_of_Drug_Administration	Oral_Route_of_Drug_administration	Sublingual Route of Administration|SL|SUBLINGUAL|Sublingual	Administration beneath the tongue.
C38301	Submucosal_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Submucosal Route of Administration|S-MUCOS|SUBMUCOSAL|Submucosal	Administration beneath the mucous membrane.
C38302	Swish_and_Spit_Route_of_Drug_Administration	Oral_Route_of_Drug_administration|Topical_Route_of_Drug_Administration	Swish and Spit Route of Administration|SWSP|Swish and Spit	Administration of a liquid substance to the oral mucosa by swishing the drug inside the mouth for a certain amount of time then spiting it out. The drug action is mostly topical/local.
C38303	Swish_and_Swallow_Route_of_Drug_Administration	Oral_Route_of_Drug_administration	Swish and Swallow Route of Administration|SWSW|Swish and Swallow	Administration of a liquid substance to the oral mucosa by swishing the drug inside the mouth for a certain amount of time then allowed to be swallowed. The drug action is both topical and systemic
C38304	Topical_Route_of_Drug_Administration	Drug_Route_of_Administration	Topical Route of Administration|T|TOPIC|TOPICAL|Topical	Administration to a particular spot on the outer surface of the body. The E2B term TRANSMAMMARY is a subset of the term TOPICAL.
C38305	Transdermal_Route_of_Drug_Administration	Drug_Route_of_Administration	Transdermal Route of Administration|Cutaneous Route of Administration|Percutaneous Route of Administration|T-DERMAL|TRANSDERMAL|Transdermal	Administration of a substance through the dermal layer of the skin into the systemic circulation by diffusion.
C38306	Transluminal_Route_of_Drug_Administration	Intravascular_Route_of_Drug_Administration	Transluminal Route of Administration|T-LUMIN|Transluminal	The route of drug administration involving the passage of an inflatable catheter along the lumen of a blood vessel.
C38307	Transplacental_Route_of_Drug_Administration	Drug_Route_of_Administration	Transplacental Route of Administration|T-PLACENT|TRANSPLACENTAL|Transplacental	Administration of a drug to an embryo in utero via systemic administration of the substance to the pregnant mother. Drugs cross the placenta through passive diffusion, active transport, pinocytosis and filtration. The properties of drugs that determine placental transfer by passive diffusion include molecular weight, pKa, lipid solubility and protein binding. Drugs with molecular weight of over 500 D are transferred incompletely. Drug metabolism and uptake can be altered by placental enzymes.
C38308	Transtracheal_Route_of_Drug_Administration	Drug_Route_of_Administration	Transtracheal Route of Administration|T-TRACHE|TRANSTRACHEAL|Transtracheal	Administration of a drug through the wall of the trachea.
C38309	Transtympanic_Route_of_Drug_Administration	Drug_Route_of_Administration	Transtympanic Route of Administration|T-TYMPAN|TRANSTYMPANIC|Transtympanic	Administration across or through the tympanic cavity.
C38310	Unassigned_Route_of_Drug_Administration	Drug_Route_of_Administration	Unassigned Route of Administration|UNAS|UNASSIGNED|Unassigned	Route of administration has not yet been assigned.
C38311	Unknown_Route_of_Drug_Administration	Drug_Route_of_Administration	Unknown Route of Administration|UNKNOWN|Unknown	Route of administration is unknown.
C38312	Ureteral_Route_of_Drug_Administration	Drug_Route_of_Administration	Ureteral Route of Administration|URETER|URETERAL|Ureter|Ureteral	Administration into the ureter.
C38313	Vaginal_Route_of_Drug_Administration	Drug_Route_of_Administration	Vaginal Route of Administration|VAG|VAGIN|VAGINAL|Vaginal	Administration into the vagina.
C38314	POLB_Gene	Polymerase_Gene	POLB Gene|POLB	Human POLB Gene (DNA Polymerase Type-X Family) encodes 334-aa 38-kDa monomeric nuclear DNA Polymerase Beta, a DNA repair enzyme that catalyzes "gap-filling" DNA synthesis in a stepwise distributive, rather than processive, fashion during base excision repair required for DNA maintenance, replication, recombination, and drug resistance. (NCI)
C38315	FOLH1_Gene	Hydrolase_Gene	FOLH1 Gene|FOLH|FOLH1|Folate Hydrolase (Prostate-Specific Membrane Antigen) 1 Gene|GCP2|NAALAD1|PSM|PSMA	Expressed on prostate epithelial cell surfaces, in small intestine brush border membranes, brain, kidney, liver, spleen, colon, and tumor-associated vascular endothelia, human FOLH1 Gene (Peptidase M28B Family) encodes Folate Hydrolase 1 (identical to glutamate carboxypeptidase II), a type II transmembrane protein with blocked N-terminus and required for folate uptake in the intestine. FOLH1 exhibits folate hydrolase activity, NAALADase activity in the central region, and C-terminal dipeptidyl peptidase IV type activity. FOLH1 modulates excitatory glutamate neurotransmission in the brain through hydrolysis of neuropeptide N-acetylaspartylglutamate (NAAG). A diagnostic and prognostic indicator of prostate cancer, FOLH1 is involved in prostate tumor progression. (NCI)
C38316	GNAQ_Gene	Heterotrimeric_G_Protein_Subunit_Gene	GNAQ Gene|GAQ|GNAQ|Guanine Nucleotide Binding Protein (G Protein), Q Polypeptide Gene	Expressed predominantly in ovary, prostate, testis, and colon, human GNAQ Gene (G-Alpha 3 (Gq) Family) encodes 353-aa 41-kDa G(q) Alpha, the alpha chain subunit of G(q) heterotrimeric G protein that contains a guanine nucleotide binding site and mediates phospholipase C-beta stimulation. Heterotrimeric G proteins are composed of alpha, beta, and gamma subunits that modulate/transduce transmembrane signaling by coupling cell surface 7-transmembrane domain receptor activity to regulating the functions of diverse cellular effectors. Receptor activation catalyzes GTP exchange for GDP bound to the inactive G protein alpha subunit, resulting in conformational change and dissociation of the heterotrimeric complex. Activation is terminated by GTPase activity intrinsic to the G-alpha subunit. GNAQ binds to SLC9A3R1. (NCI)
C38317	GNAS_Gene	Heterotrimeric_G_Protein_Subunit_Gene	GNAS Gene|AHO|GNAS|GNAS Complex Locus Gene|GNAS1|GNASXL|GPSA|GSA|GSP|NESP|NESP55|PHP1A|PHP1B|POH	Expressed in complex imprinted patterns as alternative transcripts with varied 5-prime exons (from differentially methylated regions), human GNAS Gene (G-Alpha 2 (Gs) Family) encodes G(s) Alpha, the alpha chain subunit of G(s) heterotrimeric G protein that contains a guanine nucleotide binding site and mediates hormonal activation of adenylate cyclase and cAMP signaling in response to beta-adrenergic stimuli. Heterotrimeric G proteins are composed of alpha, beta, and gamma subunits that modulate/transduce transmembrane signaling by coupling cell surface 7-transmembrane domain receptor activity to regulating the functions of diverse cellular effectors. Receptor activation catalyzes GTP exchange for GDP bound to the inactive G protein alpha subunit, resulting in conformational change and dissociation of the heterotrimeric complex. Activation is terminated by GTPase activity intrinsic to the G-alpha subunit. (NCI)
C38318	GRP_Gene	Neuropeptide_Gene	GRP Gene|GRP|Gastrin-Releasing Peptide Gene	Widely expressed in the gastrointestinal tract and nervous system, human GRP Gene (Bombesin/Neuromedin B/Ranatensin Family) encodes a 148-aa precursor of 27-aa secreted Gastrin Releasing Peptide, a gut neuropeptide/neuroregulator hormone that functions in neurotransmitter-like fashion and represents the mammalian equivalent of the amphibian bombesin tetradecapeptide. Regulating gastric acid secretion and motor function, GRP increases plasma gastrin (released from G cells), pancreatic polypeptide, glucagon, gastric inhibitory peptide, and insulin. In the fetus, GRP acts as a hormone and exerts growth factor-like activity on many organs, aiding development. (NCI)
C38319	GYPA_Gene	Transmembrane_Protein_Gene	GYPA Gene|GPA|GYPA|Glycophorin A (Includes MN Blood Group) Gene|MN|MNS	The 7-exon human GYPA Gene (Glycophorin A Family) encodes 150-aa 16-kDa (precursor) GPA (Glycophorin A), the major erythrocyte intrinsic type I membrane sialoglycoprotein. Along with GYPB, GYPA bears the antigenic determinants for the M/N and S/s blood groups. The N-terminal glycosylated extracellular segment contains the blood group receptors and binds influenza virus. (NCI)
C38320	GHRH_Gene	Peptide_Hormone_Gene	GHRH Gene|GHRF|GHRH|GRF|Growth Hormone Releasing Hormone Gene	Expressed in the hypothalamus and other tissues, human GHRH Gene (Glucagon Family) encodes 44-aa secreted Growth Hormone Releasing Hormone, a polypeptide hormone cleaved from a 108-aa 12-kDa preproprotein precursor that stimulates growth hormone release from the adenohypophysis, acts as a neurotransmitter in the central and peripheral nervous systems, and modulates kidney, pancreatic, and GI tract functions. GHRH defects cause dwarfism; hypersecretion causes gigantism. (NCI)
C38322	Marginal_Zone_B-Lymphocyte_of_Nodal_Type	Marginal_Zone_B-Lymphocyte	Marginal Zone B-Lymphocyte of Nodal Type	A lymphocyte found in the marginal zones of lymph nodes. It has a naive B lymphoid lineage and plays an important role in the early phases of immune response with its ability to rapidly differentiate into an antibody secreting cell. These cells can directly activate T cells, interact with other antigen presenting cells, transporting and concentrating antigen during the course of T-dependent and T-independent immune responses.
C38323	Peripheral_Epidermotropic_T-Lymphocyte	Mature_T-Lymphocyte	Peripheral Epidermotropic T-Lymphocyte
C38324	Mature_Cytotoxic_T-Lymphocyte	Cytotoxic_T-Lymphocyte	Mature Cytotoxic T-Lymphocyte	A peripheral white blood cell that produces cytokines and kills infected target cells. It has a CD8 marker on its surface and has been activated by contact with MHC class I receptors and cytokines.
C38325	Immature_T-Lymphocyte	Immature_Lymphocyte|T-Lymphocyte	Immature T-Lymphocyte	A cell developed in the thymus that differentiates into a mature T-lymphocyte. The maturation is dependent on several transcription factors including GATA-3 and c-Myb. The expression of the pre-T cell receptor alpha (pTa) gene occurs exclusively in the immature T lymphocyte.
C38326	Immature_Peripheral_Gamma-Delta_Cell_of_Cytotoxic_Type	Immature_T-Lymphocyte|Peripheral_Post-Thymic_T-Lymphocyte	Immature Peripheral Gamma/Delta Cell of Cytotoxic Type	A cell derived from stem cells in the bone marrow. It is a maturing T lymphocyte that expresses a gamma-delta antigen specific surface receptor (TCR). These cells exert major histocompatibility-unrestricted natural cytotoxicity against several types of solid tumors and some leukemias and lymphomas. They are also involved in the immune response to certain infections and are able to mediate antibody-dependent cytotoxicity and are not alloreactive.
C38327	Immature_Peripheral_Alpha-Beta_Cell_of_Cytotoxic_Type	Immature_T-Lymphocyte|Peripheral_Post-Thymic_T-Lymphocyte	Immature Peripheral Alpha/Beta Cell of Cytotoxic Type	A cell derived from stem cells in the bone marrow. It is a maturing T lymphocyte that expresses an alpha-beta antigen specific surface receptor (TCR) and the CD8 surface marker. These cells mature in the thymus.
C38328	Unfavorable_Clinical_Outcome	Clinical_Course_of_Disease	Unfavorable Clinical Outcome
C38329	Thymic_B-Lymphocyte	Mature_B-Lymphocyte	Thymic B-Lymphocyte	A white blood cell derived from bone marrow precursors which lack any T cell markers. It can give rise to either thymic cortical and medullary progeny, or medullary progeny alone.
C38330	Peripheral_B-Lymphocyte	Mature_B-Lymphocyte	Peripheral B-Lymphocyte	A mature B-lymphocyte outside the bone marrow. It may be in the general circulation or in lymphatic tissue.
C38331	Intraepithelial_T-Lymphocyte	Mature_T-Lymphocyte	Intraepithelial T-Lymphocyte	A mature T lymphocyte that migrates into epithelial tissue and contributes to the local and the systemic immune response.
C38332	Peripheral_B-Lymphocyte_of_Inner_Mantle_Zone	Mature_B-Lymphocyte	Peripheral B-Lymphocyte of Inner Mantle Zone
C38333	Activated_B-Lymphocyte	Activated_Lymphocyte|Mature_B-Lymphocyte	Activated B-Lymphocyte	A white blood cell produced in the bone marrow that, due to contact with an antigen, able to proliferate and differentiate into B memory cells, antibody-secreting B-lymphocytes or plasma cells.
C38334	Postgerminal_Center_Marginal_Zone_B-Lymphocyte	Marginal_Zone_B-Lymphocyte|Postgerminal_Center_B-Lymphocyte	Postgerminal Center Marginal Zone B-Lymphocyte
C38335	Germinal_Center_B-Lymphocyte	Mature_B-Lymphocyte	Germinal Center B-Lymphocyte
C38336	Interdigitating_Dendritic_Cell	Dendritic_Cell	Interdigitating Dendritic Cell|Interdigitating Cells	A dendritic cell found in the paracortex that captures blood-borne antigens in peripheral tissues and transports them to the periarteriolar lymphoid sheath where initial B and T cell activation takes place. These cells play an important role in cellular immunity.
C38337	Naive_Pregerminal_Center_B-Lymphocyte	Mature_B-Lymphocyte	Naive Pregerminal Center B-Lymphocyte	A mature B lymphocyte that expresses IgM and IgD. It is found in peripheral blood, lymph nodes and secondary lymphoid organs, but has not moved into the germinal center of lymphoid organs. Once this cell encounters an antigen in the presence of helper T cells and becomes activated, it moves to the next stage of B-lymphocyte development.
C38338	Activated_Skin-Homing_Lymphocyte	Retired_Concepts	Activated Skin-Homing Lymphocyte
C38339	Postgerminal_Center_Memory_B-Lymphocyte	Memory_B_Cell|Postgerminal_Center_B-Lymphocyte	Postgerminal Center Memory B-Lymphocyte
C38340	Postgerminal_Center_B-Lymphocyte	Mature_B-Lymphocyte	Postgerminal Center B-Lymphocyte
C38341	Postgerminal_Center_B-Lymphocyte_of_Unknown_Differentiation_Stage	Marginal_Zone_B-Lymphocyte|Postgerminal_Center_B-Lymphocyte	Postgerminal Center B-Lymphocyte of Unknown Differentiation Stage
C38342	Pancreatic_Intraductal_Papillary-Mucinous_Neoplasm	Exocrine_Pancreas_Neoplasm	Pancreatic Intraductal Papillary-Mucinous Neoplasm
C38343	JAK-STAT_Pathway_Deregulation	Molecular_Pathway_Deregulation	JAK-STAT Pathway Deregulation
C38344	RAS-RAF_Pathway_Deregulation	Molecular_Pathway_Deregulation	RAS-RAF Pathway Deregulation
C38345	JUN_Pathway_Deregulation	Molecular_Pathway_Deregulation	JUN Pathway Deregulation
C38346	MYC_Pathway_Deregulation	Molecular_Pathway_Deregulation	MYC Pathway Deregulation
C38347	P13K-AKT_Pathway_Deregulation	Molecular_Pathway_Deregulation	P13K-AKT Pathway Deregulation
C38348	MSN-ALK_Fusion_Protein_Expression	Fusion_Protein_Expression	MSN-ALK Fusion Protein Expression
C38349	ESR1_Gene	Nuclear_Receptor_Gene	ESR1 Gene|ER|ERA|ESR|ESR1|ESRA|Estrogen Receptor 1 Gene|NR3A1	Human ESR1 Gene (NR3 Family) encodes 2 alternative isoforms of Estrogen Receptor 1, a ligand-activated nuclear hormone receptor transcription factor composed of an N-terminal transcription activation/modulation domain, a DNA-binding domain, and a C-terminal steroid-binding domain. ESR1 binds DNA as a homodimer or as a heterodimer with ESR2 and interacts with NCOA3, NCOA5, and NCOA6 coactivators. Hormone-ESR1 complexes appear to recognize discrete upstream target ERE DNA sequences to regulate gene expression, cell proliferation, and differentiation. Phosphorylated by cyclin A/CDK2 may enhances transcriptional activity. (NCI)
C38350	del_4_q12	Chromosomal_Deletion	del(4)(q12)
C38351	t_1_4_q44_q12	Chromosomal_Translocation	t(1;4)(q44;q12)
C38352	_6q25_1	Chromosome_Band	6q25.1	A chromosome band present on 6q
C38353	_7q21	Chromosome_Band	7q21	A chromosome band present on 7q
C38354	_1p31_3-p31_2	Chromosome_Band	1p31.3-p31.2	A chromosome band present on 1p
C38355	_9q13	Chromosome_Band	9q13	A chromosome band present on 9q
C38356	_11q21-q22	Chromosome_Band	11q21-q22	A chromosome band present on 11q
C38358	_13q14_2-q14_3	Chromosome_Band	13q14.2-q14.3	A chromosome band present on 13q
C38359	_17p12-p11_2	Chromosome_Band	17p12-p11.2	A chromosome band present on 17p
C38360	_12q24_3	Chromosome_Band	12q24.3	A chromosome band present on 12q
C38361	Estrogen_Receptor_1	Estrogen_Receptor	Estrogen Receptor 1|ER|ER-Alpha|ESR1|Estradiol Receptor|Estrogen Receptor|Estrogen Receptor Alpha	Encoded by human ESR1 Gene (NR3 Family) as 2 alternative isoforms, Estrogen Receptor 1 is a ligand-activated nuclear hormone receptor transcription factor composed of an N-terminal transcription activation/modulation domain, a DNA-binding domain, and a C-terminal steroid-binding domain. ESR1 binds DNA as a homodimer or as a heterodimer with ESR2 and interacts with NCOA3, NCOA5, and NCOA6 coactivators. Hormone-ESR1 complexes appear to recognize discrete upstream target ERE DNA sequences to regulate gene expression, cell proliferation, and differentiation. Phosphorylated by cyclin A/CDK2 may enhances transcriptional activity. (NCI)
C38362	AML1_Mutation	Gene_Abnormality	RUNX1 Gene Mutation|AML1 Mutation|CBFalpha2 Mutation
C38363	ESR2_Gene	Nuclear_Receptor_Gene	ESR2 Gene|ER-BETA|ERB|ESR-BETA|ESR2|ESRB|ESTRB|Estrogen Receptor 2 (ER Beta) Gene|NR3A2	Widely expressed human ESR2 Gene (NR3 Family) encodes 8 alternative isoforms of Estrogen Receptor 2, a ligand-activated nuclear hormone receptor transcription factor composed of an N-terminal transcription activation/modulation domain, a DNA-binding domain, and a C-terminal steroid-binding domain. ESR2 binds estrogens with an affinity similar to ESR1 and transduces extracellular hormone signals into transcriptional responses by binding ERE DNA as a homodimer or as a heterodimer with ESR1, NCOA3, NCOA5, or NCOA6 coactivators and activating target gene expression in an estrogen-dependent manner; DNA-binding is lost in the absence of ligand. Lacking ligand binding ability and ERE binding activity, isoform Beta-2/CX preferentially forms a heterodimer with ESR1 and inhibits ligand-dependent DNA-binding and transactivation. (NCI)
C38364	Estrogen_Receptor_2	Estrogen_Receptor	Estrogen Receptor 2|ER-Beta|ESR2|Estrogen Receptor Beta	Widely expressed by human ESR2 Gene (NR3 Family) as 8 alternative isoforms, Estrogen Receptor 2 is a ligand-activated nuclear hormone receptor transcription factor composed of an N-terminal transcription activation/modulation domain, a DNA-binding domain, and a C-terminal steroid-binding domain. ESR2 binds estrogens with an affinity similar to ESR1 and transduces extracellular hormone signals into transcriptional responses by binding ERE DNA as a homodimer or as a heterodimer with ESR1, NCOA3, NCOA5, or NCOA6 coactivators and activating target gene expression in an estrogen-dependent manner; DNA-binding is lost in the absence of ligand. Lacking ligand binding ability and ERE binding activity, isoform Beta-2/CX preferentially forms a heterodimer with ESR1 and inhibits ligand-dependent DNA-binding and transactivation. (NCI)
C38365	TOP3B_Gene	Isomerase_Gene	TOP3B Gene|TOP3B|Topoisomerase (DNA) II Beta 180kDa Gene	Expressed as 3 alternative isoforms in testis, heart, skeletal muscle, thymus, kidney, and pancreas, human TOP3B Gene (Topoisomerase I/III Family) encodes Topoisomerase III Beta, a DNA topoisomerase that interacts with DNA helicase SGS1; plays a role in DNA recombination, cellular aging, and maintenance of genome stability; and controls/alters DNA topology by relieving torsional stress in negatively supercoiled DNA during transcription. TOP3B catalyzes transient ATP-independent breaking and rejoining of DNA single-strands. Alternative C-terminal splicing results in three transcript variants that have distinct tissue specificity. (NCI)
C38366	Topoisomerase-III_Beta	Topoisomerase-III	Topoisomerase III Beta|DNA Topoisomerase III Beta|TOP3B|Topoisomerase IIIB	Expressed as 3 alternative isoforms in testis, heart, skeletal muscle, thymus, kidney, and pancreas by human TOP3B Gene (Topoisomerase I/III Family), Topoisomerase III Beta is a DNA topoisomerase that interacts with DNA helicase SGS1; plays a role in DNA recombination, cellular aging, and maintenance of genome stability; and controls/alters DNA topology by relieving torsional stress in negatively supercoiled DNA during transcription. TOP3B catalyzes transient ATP-independent breaking and rejoining of DNA single-strands. Alternative C-terminal splicing results in three transcript variants that have distinct tissue specificity. (NCI)
C38367	USF1_Gene	Transcription_Factor_Gene	USF1 Gene|FCHL1|HYPLIP1|MLTF|MLTFI|UEF|USF|USF1|Upstream Transcription Factor 1 Gene	Ubiquitously expressed human USF1 Gene encodes 310-aa 34-kDa nuclear Upstream Stimulatory Factor 1, a bHLH transcription factor that binds to symmetrical E-box DNA (CACGTG) in viral and cellular promoters as a homodimer or USF1/USF2 heterodimer (USF). Efficient DNA binding requires dimerization with another bHLH protein and USF1 can act synergistically with GTF2I to activate transcription. Direct GTF2I interaction requires the USF1 activation and dimerization domains. USF1/USF2A heterodimer represents most USF binding activity. (NCI)
C38368	Upstream_Stimulatory_Factor_1	Protein_Complex_Subunit	Upstream Stimulatory Factor 1|Major Late Transcription Factor 1|USF1	Ubiquitously expressed by human USF1 Gene, 310-aa 34-kDa nuclear Upstream Stimulatory Factor 1 is a bHLH transcription factor that binds to symmetrical E-box DNA (CACGTG) in viral and cellular promoters as a homodimer or USF1/USF2 heterodimer (USF). Efficient DNA binding requires dimerization with another bHLH protein and USF1 can act synergistically with GTF2I to activate transcription. Direct GTF2I interaction requires the USF1 activation and dimerization domains. USF1/USF2A heterodimer represents most USF binding activity. (NCI)
C38369	USF2_Gene	Transcription_Factor_Gene	USF2 Gene|FIP|USF2|Upstream Transcription Factor 2, c-FOS Interacting Gene	Ubiquitously expressed by a putative GC-rich housekeeping promoter as 3 alternative isoforms, 11-kb 10-exon human USF2 Gene encodes nuclear Upstream Stimulatory Factor 2, a bHLH transcription factor involved in transcription of a variety of cellular genes that binds to symmetrical E-box DNA (CACGTG) in viral and cellular promoters as a homodimer or USF1/USF2 heterodimer (USF). Efficient DNA binding requires dimerization with another bHLH protein. USF1/USF2A heterodimer represents most USF binding activity. (NCI)
C38370	Upstream_Stimulatory_Factor_2	Protein_Complex_Subunit	Upstream Stimulatory Factor 2|FIP|FOS-Interacting Protein|Major Late Transcription Factor 2|USF2|Upstream Transcription Factor 2	Ubiquitously expressed as 3 alternative isoforms by human USF2 Gene, nuclear Upstream Stimulatory Factor 2 is a bHLH transcription factor involved in transcription of a variety of cellular genes that binds to symmetrical E-box DNA (CACGTG) in viral and cellular promoters as a homodimer or USF1/USF2 heterodimer (USF). Efficient DNA binding requires dimerization with another bHLH protein. USF1/USF2A heterodimer represents most USF binding activity. (NCI)
C38371	GNAI1_Gene	Heterotrimeric_G_Protein_Subunit_Gene	GNAI1 Gene|GNAI1|Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 1 Gene	Expressed as at least 2 classes of mRNA (brain and monocyte), human GNAI1 Gene (G-Alpha 1 Family) encodes 353-aa 40-kDa G(i) Alpha 1 Protein, a guanine nucleotide-binding alpha protein subunit of heterotrimeric G protein transducers (alpha, beta, gamma) in transmembrane signaling systems involved in hormonal regulation of adenylate cyclase. At least 3 nonallelic human genes encode alpha-i-type G protein subunits; GNAI1 is the predominant alpha(i) of brain. Containing virtually identical/similar beta and gamma chains, G proteins are most distinguished by alpha chains. G(i) proteins (alpha(i) subunit) inhibit cyclase in response to beta-adrenergic stimuli. Specific alpha chain regions appear to interact with guanine nucleotides, receptors, effector enzymes, and G protein beta-gamma complex. G proteins that inhibit adenylate kinase and regulate other plasma membrane enzymes are substrates for pertussis toxin. (NCI)
C38372	C_EBPalpha_Mutation	Gene_Abnormality	CEBPA Gene Mutation|C/EBPalpha Mutation
C38373	OTT-MAL_Fusion_Protein_Expression	Fusion_Protein_Expression	OTT-MAL Fusion Protein Expression|RBM15-MLK1 Fusion Protein Expression
C38374	t_8_22_p11_q13	Chromosomal_Translocation	t(8;22)(p11;q13)
C38375	t_V_11_v_q23	Chromosomal_Translocation	t(V;11)(v;q23)
C38377	Acute_Promyelocytic_Leukemia_with_t_17_17_q11_q11	Acute_Promyelocytic_Leukemia_with_Variant_Translocations	Acute Promyelocytic Leukemia with t(17;17)(q11;q11)
C38378	t_17_17_q11_q11	Chromosomal_Translocation	t(17;17)(q11;q11)
C38379	STAT5-RARalpha_Fusion_Protein_Expression	Fusion_Protein_Expression	STAT5-RARalpha Fusion Protein Expression
C38380	G-i_Alpha-1_Protein	G-i_Alpha	G(i) Alpha 1 Protein|Adenylate Cyclase-Inhibiting G Alpha Protein|G Protein Alpha Inhibiting Activity Polypeptide 1|GNAI1|Gi1 Protein Alpha Subunit|Guanine Nucleotide Binding Protein Alpha Inhibiting Activity Polypeptide 1|Guanine Nucleotide-Binding Protein G(i) Alpha-1 Subunit	Expressed as at least 2 classes (brain and monocyte) by human GNAI1 Gene (G-Alpha 1 Family), 353-aa 40-kDa G(i) Alpha 1 Protein is a guanine nucleotide-binding alpha protein subunit of heterotrimeric G protein transducers (alpha, beta, gamma) in transmembrane signaling systems involved in hormonal regulation of adenylate cyclase. GNAI1 is the predominant alpha(i) of brain. Containing virtually identical/similar beta and gamma chains, G proteins are most distinguished by alpha chains. G(i) proteins (alpha(i) subunit) inhibit cyclase in response to beta-adrenergic stimuli. Specific alpha chain regions appear to interact with guanine nucleotides, receptors, effector enzymes, and G protein beta-gamma complex. G proteins that inhibit adenylate kinase and regulate other plasma membrane enzymes are substrates for pertussis toxin. (NCI)
C38381	GNAI3_Gene	Heterotrimeric_G_Protein_Subunit_Gene	GNAI3 Gene|GNAI3|Guanine Nucleotide Binding Protein (G Protein), Alpha Inhibiting Activity Polypeptide 3 Gene	Human GNAI3 Gene (G-Alpha 1 Family) encodes 353-aa 40-kDa G(i) Alpha 3 Protein, a guanine nucleotide-binding alpha protein subunit of heterotrimeric G protein transducers (alpha, beta, gamma) in transmembrane signaling systems involved in hormonal regulation of adenylate cyclase. At least 3 nonallelic human genes encode alpha-i-type G protein subunits; GNAI2 and GNAI3 possess identical exon-intron organization. Containing virtually identical/similar beta and gamma chains, G proteins are most distinguished by alpha chains. G(i) proteins (alpha(i) subunit) inhibit cyclase in response to beta-adrenergic stimuli. Specific alpha chain regions appear to interact with guanine nucleotides, receptors, effector enzymes, and G protein beta-gamma complex. G proteins that inhibit adenylate kinase are substrates for pertussis toxin. GNAI3 is the stimulatory G protein of receptor-regulated K(+) channels. (NCI)
C38382	G-i_Alpha-3_Protein	G-i_Alpha	G(i) Alpha 3 Protein|87U6|G Protein Alpha Inhibiting Activity Polypeptide 3|G(i) Alpha-3|GNAI3|Guanine Nucleotide Binding Protein Alpha Inhibiting Activity Polypeptide 3|Guanine Nucleotide-Binding Protein G(k) Alpha Subunit	Encoded by human GNAI3 Gene (G-Alpha 1 Family), 353-aa 40-kDa G(i) Alpha 3 Protein is a guanine nucleotide-binding alpha protein subunit of heterotrimeric G protein transducers (alpha, beta, gamma) in transmembrane signaling systems involved in hormonal regulation of adenylate cyclase. Containing virtually identical/similar beta and gamma chains, G proteins are most distinguished by alpha chains. G(i) proteins (alpha(i) subunit) inhibit cyclase in response to beta-adrenergic stimuli. Specific alpha chain regions appear to interact with guanine nucleotides, receptors, effector enzymes, and G protein beta-gamma complex. G proteins that inhibit adenylate kinase are substrates for pertussis toxin. GNAI3 is the stimulatory G protein of receptor-regulated K(+) channels. (NCI)
C38383	Aneuploid_Dysplastic_Oral_Leukoplakia	Oral_Leukoplakia	Aneuploid Dysplastic Oral Leukoplakia
C38384	del_5_q12_q35	Chromosomal_Deletion	del(5)(q12;q35)
C38385	del_7_q11_q36	Chromosomal_Deletion	del(7)(q11;q36)
C38386	del_20_q11	Chromosomal_Deletion	del(20)(q11)
C38387	MLL-AF10_Fusion_Protein_Expression	Fusion_Protein_Expression	MLL-AF10 Fusion Protein Expression
C38388	Ventilator	Medical_Device	Ventilator	A medical device that facilitates breathing.
C38389	Sex_Personal_Attribute	Retired_Concepts	Sex
C38390	MLL-AF9_Fusion_Protein_Expressin	Fusion_Protein_Expression	MLL-AF9 Fusion Protein Expression
C38391	MLL-ENL_Fusion_Protein_Expression	Fusion_Protein_Expression	MLL-ENL Fusion Protein Expression
C38392	MLL-ELL_Fusion_Protein_Expression	Fusion_Protein_Expression	MLL-ELL Fusion Protein Expression
C38393	MLL-EEN_Fusion_Protein_Expression	Fusion_Protein_Expression	MLL-EEN Fusion Protein Expression
C38394	NFKBIB_Gene	Signaling_Pathway_Gene	NFKBIB Gene|IKBB|NFKBIB|Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, Beta Gene|TRIP9	Widely expressed human NFKBIB Gene (NFKBI Family) encodes 317-aa 36-kDa cytoplasmic I-Kappa-B-Beta, containing 6 ANK repeats and interacting with the ligand-binding domain of Thyroid Hormone Receptor-Beta, Inhibitor Kappa B-Interacting RAS-Like Protein 1, Inhibitor Kappa B-Interacting Protein RAS2, p65 RELA, and c-REL. By complexing with and trapping NF-Kappa-B in the cytoplasm, unphosphorylated NFKBIB inhibits and likely regulates NFKB. NFKBIB phosphorylation leads to degradation. Association with Inhibitor Kappa B-Interacting RAS-Like Proteins 1 and 2 may slow degradation. (NCI)
C38395	I-Kappa-B-Beta_Protein	I-Kappa-B_Protein	I-Kappa-B-Beta|IKB-B|IKB-Beta|NF-Kappa B Inhibitor Beta|NF-Kappa-B IB|NFKBIB|Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor Beta|TR-Interacting Protein 9|Thyroid Receptor Interacting Protein 9	Widely expressed by human NFKBIB Gene (NFKBI Family), 317-aa 36-kDa cytoplasmic I-Kappa-B-Beta contains 6 ANK repeats and interacts with the ligand-binding domain of Thyroid Hormone Receptor-Beta, Inhibitor Kappa B-Interacting RAS-Like Protein 1, Inhibitor Kappa B-Interacting Protein RAS2, p65 RELA, and c-REL. By complexing with and trapping NF-Kappa-B in the cytoplasm, unphosphorylated NFKBIB inhibits and likely regulates NFKB. NFKBIB phosphorylation leads to degradation. Association with Inhibitor Kappa B-Interacting RAS-Like Proteins 1 and 2 may slow degradation. (NCI)
C38396	NFKBIE_Gene	Signaling_Pathway_Gene	NFKBIE Gene|IKBE|NFKBIE|Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor, Epsilon Gene	Expressed in spleen, testis, lung, kidney, pancreas, heart, placenta, brain, granulocytes, and macrophages, human NFKBIE Gene (NFKBI Family) encodes 361-aa 38-kDa cytoplasmic I-Kappa-B-Epsilon, containing 6 ANK repeats and preferentially interacting with p65 RELA homodimers and with p65-cRel heterodimers. By complexing with and trapping NF-Kappa-B in the cytoplasm, NFKBIE inhibits and likely regulates NFKB. Serine phosphorylation of NFKBIE results in proteasome-dependent degradation. (NCI)
C38397	I-Kappa-B-Epsilon_Protein	I-Kappa-B_Protein	I-Kappa-B-Epsilon|IKB-Epsilon|IKBE|NF-Kappa B Inhibitor Epsilon|NF-Kappa-B IE|NFKBIE|Nuclear Factor of Kappa Light Polypeptide Gene Enhancer in B-Cells Inhibitor Epsilon	Expressed in spleen, testis, lung, kidney, pancreas, heart, placenta, brain, granulocytes, and macrophages by human NFKBIE Gene (NFKBI), 361-aa 38-kDa cytoplasmic I-Kappa-B-Epsilon contains 6 ANK repeats and preferentially interacts with p65 RELA homodimers and with p65-cRel heterodimers. By complexing with and trapping NF-Kappa-B in the cytoplasm, NFKBIE inhibits and likely regulates NFKB. Serine phosphorylation of NFKBIE results in proteasome-dependent degradation. (NCI)
C38398	NF-I_Gene	Transcription_Factor_Gene	NF-I Gene|CTF|NFI	Widely expressed human NF-I Genes (CTF/NF-I Family) encode NF-I Proteins that contain a DWA/MH1 domain and bind TTGGCNNNNNGCCAA DNA palindromes in viral and cellular promoters as a homodimeric factor capable of activating transcription and replication. (NCI)
C38399	NFIA_Gene	NF-I_Gene	NFIA Gene|NF-IA|NFI-L|NFIA|Nuclear Factor I/A Gene	Expressed in heart, liver, brain, lung, ovary, skeletal muscle, kidney, testis, fetal liver, fetal brain, pancreas, and spleen, 11-exon human NFIA Gene (CTF/NF-I Family) encodes 509-aa 56-kDa NF-IA Protein containing 1 DWA/MH1 domain that binds TTGGCNNNNNGCCAA DNA palindromes in viral and cellular promoters as a homodimeric factor capable of activating transcription and replication. (NCI)
C38400	NF-IA_Protein	NF-I	NF-IA Protein|CCAAT-Box Binding Transcription Factor|CTF|NF-I/A|NF-IA|NF1-A|NFI-L|NFIA|Nuclear Factor 1 A-Type|Nuclear Factor I/A|TGGCA-Binding Protein	Expressed in heart, liver, brain, lung, ovary, skeletal muscle, kidney, testis, fetal liver, fetal brain, pancreas, and spleen by human NFIA Gene (CTF/NF-I Family), 509-aa 56-kDa NF-IA Protein contains 1 DWA/MH1 domain and binds TTGGCNNNNNGCCAA DNA palindromes in viral and cellular promoters as a homodimeric factor capable of activating transcription and replication. (NCI)
C38401	NFIB_Gene	NF-I_Gene	NFIB Gene|NF-IB|NFI-RED|NFIB2|NFIB3|Nuclear Factor I/B Gene	Expressed as 3 alternative isoforms, 12-exon human NFIB Gene (CTF/NF-I Family) encodes nuclear NF-IB Protein, containing an N-terminal DNA-binding domain, a C-terminal transactivation domain, and a DWA/MH1 domain, that binds TTGGCNNNNNGCCAA DNA palindromes in viral and cellular promoters as a homodimeric factor capable of activating transcription and replication. Translated from a 1.8-kb message 188-aa truncated NFIB3 protein contains only the N-terminal DNA-binding domain. NFIB3 forms heterodimers with other NFI proteins, reduces their ability to bind DNA, and may repress transcription by other NFI proteins. (NCI)
C38402	NF-IB_Protein	NF-I	NF-IB Protein|CCAAT-Box Binding Transcription Factor|CTF|NF-I/B|NF-IB|NF1-B|NFI-B|NFI-RED|NFIB|NFIB2|NFIB3|Nuclear Factor 1 B-Type|Nuclear Factor I/B|TGGCA-Binding Protein	Expressed as 3 alternative isoforms by human NFIB Gene (CTF/NF-I Family), nuclear NF-IB Protein contains an N-terminal DNA-binding domain, a C-terminal transactivation domain, and a DWA/MH1 domain. NF-IB binds TTGGCNNNNNGCCAA DNA palindromes in viral and cellular promoters as a homodimeric factor capable of activating transcription and replication. Truncated 188-aa NFIB3 protein contains only the N-terminal DNA-binding domain, forms heterodimers with other NFI proteins, reduces their ability to bind DNA, and may repress transcription by other NFI proteins. (NCI)
C38403	NFIC-Gene	NF-I_Gene	NFIC Gene|CTF|CTF5|NF-I|NF-IC|NFI|NFIC|Nuclear Factor I/C (CCAAT-Binding Transcription Factor) Gene	Expressed as 5 alternative isoforms, 11-exon human NFIC Gene (CTF/NF-I Family) encodes nuclear NF-IC Protein containing a DWA/MH1 domain that binds TTGGCNNNNNGCCAA DNA palindromes in viral and cellular promoters as a homodimeric factor capable of activating transcription and replication. (NCI)
C38404	NF-IC_Protein	NF-I	NF-IC Protein|CCAAT-Binding Transcription Factor|CCAAT-Box Binding Transcription Factor|CTF|NF-I/C|NF1-C|NFI-C|NFIC|Nuclear Factor 1 C-Type|Nuclear Factor 1/C|Nuclear Factor I/C|TGGCA-Binding Protein	Expressed as 5 alternative isoforms by human NFIC Gene (CTF/NF-I Family), nuclear NF-IC Protein contains a DWA/MH1 domain and binds TTGGCNNNNNGCCAA DNA palindromes in viral and cellular promoters as a homodimeric factor capable of activating transcription and replication. (NCI)
C38405	NFIX_Gene	NF-I_Gene	NFIX Gene|NF-IX|NFIX|Nuclear Factor I/X (CCAAT-Binding Transcription Factor) Gene	Ubiquitously expressed as 5 alternative isoforms, 11-exon human NFIX Gene (CTF/NF-I Family) encodes 47-kD nuclear NF-IX Protein, containing 1 DWA/MH1 domain, that binds TTGGCNNNNNGCCAA DNA palindromes in viral and cellular promoters as a homodimeric factor capable of activating transcription and replication. NF-IX is capable of stimulating gene transcription in cooperation with other factors, such as estrogen receptor. (NCI)
C38406	NF-IX_Protein	NF-I	NF-IX Protein|CCAAT-Binding Transcription Factor|CTF|NF-I/X|NF1-X|NFI-X|NFIX|Nuclear Factor 1 X-Type|Nuclear Factor I/X|TGGCA-Binding Protein	Ubiquitously expressed as 5 alternative isoforms by human NFIX Gene (CTF/NF-I Family), 47-kD nuclear NF-IX Protein contains 1 DWA/MH1 domain and binds TTGGCNNNNNGCCAA DNA palindromes in viral and cellular promoters as a homodimeric factor capable of activating transcription and replication. NF-IX is capable of stimulating gene transcription in cooperation with other factors, such as estrogen receptor. (NCI)
C38407	C-KIT_Somatic_Point_Mutation	C-KIT_Mutation	C-KIT Somatic Point Mutation|CD117 Somatic Point Mutation
C38408	Progressive_Transformation_of_Germinal_Centers	Morphologic_Finding	Progressive Transformation of Germinal Centers
C38409	PRKACA_Gene	Serine-Threonine_Protein_Kinase_Gene	PRKACA Gene|PKACA|PRKACA|Protein Kinase, cAMP-Dependent, Catalytic, Alpha Gene	Expressed as 2 alternative isoforms (sperm-specific Isoform 2), human PRKACA Gene (cAMP Ser/Thr Protein Kinase Family) encodes Protein Kinase A C-Alpha, a catalytic subunit of tetrameric inactive cytoplasmic holoenzyme Protein Kinase A. Homo- or heterodimeric regulatory subunits of inactive PKA holoenzyme are associated with two catalytic subunits. Most cellular effects of cAMP are mediated through PKA. cAMP-induced dissociation of holoenzyme releases a dimer of cAMP-bound regulatory subunits and free monomeric catalytic subunits that serine/threonine phosphorylate many cytoplasmic and nuclear substrates. (NCI)
C38410	Protein_Kinase-A_C-Alpha	Protein_Kinase-A	Protein Kinase A C-Alpha|PKA C-Alpha|PRKACA|cAMP-Dependent Protein Kinase Alpha|cAMP-Dependent Protein Kinase Alpha-Catalytic Subunit	Expressed as 2 alternative isoforms (sperm-specific Isoform 2) by human PRKACA Gene (cAMP Ser/Thr Protein Kinase Family), Protein Kinase A C-Alpha is a catalytic subunit of tetrameric inactive cytoplasmic holoenzyme Protein Kinase A. Homo- or heterodimeric regulatory subunits of inactive PKA holoenzyme are associated with two catalytic subunits. Most cellular effects of cAMP are mediated through PKA. cAMP-induced dissociation of holoenzyme releases a dimer of cAMP-bound regulatory subunits and free monomeric catalytic subunits that serine/threonine phosphorylate many cytoplasmic and nuclear substrates. (NCI)
C38411	PRKACB_Gene	Serine-Threonine_Protein_Kinase_Gene	PRKACB Gene|PRKACB|Protein Kinase, cAMP-Dependent, Catalytic, Beta Gene	Human PRKACB Gene (cAMP Ser/Thr Protein Kinase Family) encodes 350-aa 40-kDa Protein Kinase A C-Beta, a catalytic subunit of tetrameric inactive cytoplasmic holoenzyme Protein Kinase A. Homo- or heterodimeric regulatory subunits of inactive PKA holoenzyme are associated with two catalytic subunits. Most cellular effects of cAMP are mediated through PKA. cAMP-induced dissociation of holoenzyme releases a dimer of cAMP-bound regulatory subunits and free monomeric catalytic subunits that serine/threonine phosphorylate many cytoplasmic and nuclear substrates. (NCI)
C38412	Protein_Kinase-A_C-Beta	Protein_Kinase-A	Protein Kinase A C-Beta|PKA C-Beta|PRKACB|cAMP-Dependent Protein Kinase Beta|cAMP-Dependent Protein Kinase Beta-Catalytic Subunit	Encoded by human PRKACB Gene (cAMP Ser/Thr Protein Kinase Family), 350-aa 40-kDa Protein Kinase A C-Beta is a catalytic subunit of tetrameric inactive cytoplasmic holoenzyme Protein Kinase A. Homo- or heterodimeric regulatory subunits of inactive PKA holoenzyme are associated with two catalytic subunits. Most cellular effects of cAMP are mediated through PKA. cAMP-induced dissociation of holoenzyme releases a dimer of cAMP-bound regulatory subunits and free monomeric catalytic subunits that serine/threonine phosphorylate many cytoplasmic and nuclear substrates. (NCI)
C38413	PRKACG_Gene	Serine-Threonine_Protein_Kinase_Gene	PRKACG Gene|PRKACG|Protein Kinase, cAMP-dependent, Catalytic, Gamma Gene	Thought to be a retrotransposon-derived form of PRKACBA, intronless human PRKACG Gene (cAMP Ser/Thr Protein Kinase Family) encodes 350-aa 40-kDa Protein Kinase A C-Gamma (may be testis-specific), a catalytic subunit of tetrameric inactive cytoplasmic holoenzyme Protein Kinase A. Homo- or heterodimeric regulatory subunits of inactive PKA holoenzyme are associated with two catalytic subunits. Most cellular effects of cAMP are mediated through PKA. cAMP-induced dissociation of holoenzyme releases a dimer of cAMP-bound regulatory subunits and free monomeric catalytic subunits that serine/threonine phosphorylate many cytoplasmic and nuclear substrates. (NCI)
C38414	Protein_Kinase-A_C-Gamma	Protein_Kinase-A	Protein Kinase A C-Gamma|KAPG|PKA C-Gamma|PRKACG|cAMP-Dependent Protein Kinase Gamma	Encoded by human PRKACG Gene (cAMP Ser/Thr Protein Kinase Family), 350-aa 40-kDa Protein Kinase A C-Gamma (may be testis-specific) is a catalytic subunit of tetrameric inactive cytoplasmic holoenzyme Protein Kinase A. Homo- or heterodimeric regulatory subunits of inactive PKA holoenzyme are associated with two catalytic subunits. Most cellular effects of cAMP are mediated through PKA. cAMP-induced dissociation of holoenzyme releases a dimer of cAMP-bound regulatory subunits and free monomeric catalytic subunits that serine/threonine phosphorylate many cytoplasmic and nuclear substrates. (NCI)
C38415	RXRA_Gene	Nuclear_Receptor_Gene	RXRA Gene|NR2B1|RXRA|Retinoid X Receptor, Alpha Gene	Expressed in liver, lung, kidney, and heart, human RXRA Gene (NR2/RXR Family) encodes 462-aa 51-kDa nuclear Retinoid X Receptor Alpha, a transcriptional regulator composed of N-terminal modulating domain, DNA-binding domain, and C-terminal 9-cis RA-binding domain. Involved in the retinoic acid response pathway, RXRA interacts with NCOA3 and NCOA6 coactivators and mediates RA biological effects by binding to specific target gene promoter sequences as homo- or heterodimers and inducing retinoic acid-mediated activation of target gene transcription. RXR/LXRs and RXR/FXR may mediate cholesterol homeostasis, by governing cholesterol transport from peripheral cells, inhibiting cholesterol absorption in the small intestine, and repressing bile acid synthesis through upregulation of ABC1 and repression of CYP7A1 expression. (NCI)
C38416	Retinoid_X_Receptor_Alpha	Retinoid-X_Receptor	Retinoid X Receptor Alpha|RXRA|Retinoic Acid Receptor RXR-Alpha|Retinoid X Receptor A	Expressed in liver, lung, kidney, and heart by human RXRA Gene (NR2/RXR Family), 462-aa 51-kDa nuclear Retinoid X Receptor Alpha is a transcriptional regulator composed of N-terminal modulating domain, DNA-binding domain, and C-terminal 9-cis RA-binding domain. Involved in the retinoic acid response pathway, RXRA interacts with NCOA3 and NCOA6 coactivators and mediates RA biological effects by binding to specific target gene promoter sequences as homo- or heterodimers and inducing retinoic acid-mediated activation of target gene transcription. RXR/LXRs and RXR/FXR may mediate cholesterol homeostasis, by governing cholesterol transport from peripheral cells, inhibiting cholesterol absorption in the small intestine, and repressing bile acid synthesis through upregulation of ABC1 and repression of CYP7A1 expression. (NCI)
C38417	RXRB_Gene	Nuclear_Receptor_Gene	RXRB Gene|DAUDI6|NR2B2|RXRB|Retinoid X Receptor, Beta Gene	Expressed as 2 alternative isoforms, human RXRB Gene (NR2/RXR Family) encodes nuclear Retinoid X Receptor Beta, a transcriptional regulator composed of N-terminal modulating domain, DNA-binding domain, and C-terminal 9-cis RA-binding domain. Involved in the retinoic acid response pathway, RXRB forms homodimers and heterodimers with RA-, TH-, and vitamin D receptors and mediates RA biological effects by binding specific target gene promoter sequences and inducing activation of target gene transcription. RARB/RXRB and RARB/RXRG may regulate locomotion and be functionally redundant. RXR/LXRs and RXR/FXR may mediate cholesterol homeostasis, by governing cholesterol transport from peripheral cells, inhibiting cholesterol absorption in the small intestine, and repressing bile acid synthesis through upregulation of ABC1 and repression of CYP7A1 expression. (NCI)
C38418	Retinoid_X_Receptor_Beta	Retinoid-X_Receptor	Retinoid X Receptor Beta|H-2RIIBP|MHC Class I Promoter Binding Protein|NR2B2|RCoR-1|RXRB|Retinoic Acid Receptor RXR-Beta|Retinoid X Receptor B	Expressed as 2 alternative isoforms by human RXRB Gene (NR2/RXR Family), nuclear Retinoid X Receptor Beta is a transcriptional regulator composed of N-terminal modulating domain, DNA-binding domain, and C-terminal 9-cis RA-binding domain. Involved in the retinoic acid response pathway, RXRB forms homodimers and heterodimers with RA-, TH-, and vitamin D receptors and mediates RA biological effects by binding specific target gene promoter sequences and inducing activation of target gene transcription. RARB/RXRB and RARB/RXRG may regulate locomotion and be functionally redundant. RXR/LXRs and RXR/FXR may mediate cholesterol homeostasis, by governing cholesterol transport from peripheral cells, inhibiting cholesterol absorption in the small intestine, and repressing bile acid synthesis through upregulation of ABC1 and repression of CYP7A1 expression. (NCI)
C38419	RXRG_Gene	Nuclear_Receptor_Gene	RXRG Gene|NR2B3|RXRC|RXRG|Retinoid X Receptor, Gamma Gene	Human RXRG Gene (NR2/RXR Family) encodes 463-aa 51-kDa nuclear Retinoid X Receptor Gamma, a transcriptional regulator composed of N-terminal modulating domain, DNA-binding domain, and C-terminal 9-cis RA-binding domain. Involved in the retinoic acid response pathway, RXRG acts as heterodimeric partner for RARA, RARB, RARG, TH-, and vitamin D receptor and mediates RA biological effects by binding specific target gene promoter sequences and inducing activation of target gene transcription. RARB/RXRB and RARB/RXRG may regulate locomotion and be functionally redundant. RXR/LXRs and RXR/FXR may mediate cholesterol homeostasis, by governing cholesterol transport from peripheral cells, inhibiting cholesterol absorption in the small intestine, and repressing bile acid synthesis through upregulation of ABC1 and repression of CYP7A1 expression. (NCI)
C38420	Retinoid_X_Receptor_Gamma	Retinoid-X_Receptor	Retinoid X Receptor Gamma|RXRG|Retinoic Acid Receptor RXR-Gamma|Retinoid X Receptor G	Encoded by human RXRG Gene (NR2/RXR Family), 463-aa 51-kDa nuclear Retinoid X Receptor Gamma is a transcriptional regulator composed of N-terminal modulating domain, DNA-binding domain, and C-terminal 9-cis RA-binding domain. Involved in the retinoic acid response pathway, RXRG acts as heterodimeric partner for RARA, RARB, RARG, TH-, and vitamin D receptor and mediates RA biological effects by binding specific target gene promoter sequences and inducing activation of target gene transcription. RARB/RXRB and RARB/RXRG may regulate locomotion and be functionally redundant. RXR/LXRs and RXR/FXR may mediate cholesterol homeostasis, by governing cholesterol transport from peripheral cells, inhibiting cholesterol absorption in the small intestine, and repressing bile acid synthesis through upregulation of ABC1 and repression of CYP7A1 expression. (NCI)
C38421	GUCY1A2_Gene	Protein_Complex_Subunit_Gene	GUCY1A2 Gene|GC-SA2|GUC1A2|GUCSA2|GUCY1A2|Guanylate Cyclase 1, Soluble, Alpha 2 Gene	Expressed as alternative isoforms in testis and fetal brain (Isoform 1), and in liver, colon, and endothelium (Isoform 1, 2), human GUCY1A2 Gene (Adenylyl Cyclase 4/Guanylyl Cyclase Family) encodes cytoplasmic Soluble Guanylate Cyclase 1 Alpha 2, a subunit of nitric oxide-activated heterodimeric (alpha/beta) soluble guanylate cyclases that catalyze conversion of GTP to cGMP second messenger. With regions of high similarity to alpha-1, GUCY1A2 exhibits guanylyl cyclase activity on binding to the beta subunit. Isoform alpha-2-I acts as a negative guanylyl cylase regulator; forming non-functional heterodimers with beta subunits. (NCI)
C38422	Soluble_Guanylate_Cyclase-1-Alpha-2	Protein_Complex_Subunit	Soluble Guanylate Cyclase 1 Alpha 2|GCS-Alpha-2|GUCY1A2|Soluble Guanylate Cyclase 1A2|Soluble Guanylate Cyclase Alpha-2 Chain	Expressed as alternative isoforms in testis and fetal brain (Isoform 1), and in liver, colon, and endothelium (Isoform 1, 2) by human GUCY1A2 Gene (Adenylyl Cyclase 4/Guanylyl Cyclase Family), cytoplasmic Soluble Guanylate Cyclase 1 Alpha 2 is a subunit of nitric oxide-activated heterodimeric (alpha/beta) soluble guanylate cyclases that catalyze conversion of GTP to cGMP second messenger. With regions of high similarity to alpha-1, GUCY1A2 exhibits guanylyl cyclase activity on binding to the beta subunit. Isoform alpha-2-I acts as a negative guanylyl cylase regulator; forming non-functional heterodimers with beta subunits. (NCI)
C38423	Pleomorphic_Reed_Sternberg_Cell	Reed-Sternberg_Cell	Pleomorphic Reed-Sternberg Cell
C38424	GUCY1A3_Gene	Protein_Complex_Subunit_Gene	GUCY1A3 Gene|GC-SA3|GUC1A3|GUCA3|GUCSA3|GUCY1A1|GUCY1A3|Guanylate Cyclase 1, Soluble, Alpha 3 Gene	Human GUCY1A3 Gene (Adenylyl Cyclase 4/Guanylyl Cyclase Family) encodes 690-aa 77-kDa cytoplasmic Soluble Guanylate Cyclase 1 Alpha 3, a subunit of heterodimeric (alpha/beta) soluble guanylate cyclases, the main receptors for nitric oxide and nitrovasodilator drugs that catalyze conversion of GTP to cGMP second messenger. (NCI)
C38425	_4q31_3-q33	Chromosome_Band	4q31.3-q33	A chromosome band present on 4q
C38426	Soluble_Guanylate_Cyclase-1-Alpha-3	Protein_Complex_Subunit	Soluble Guanylate Cyclase 1 Alpha 3|GCS-Alpha-1|GCS-Alpha-3|GUCY1A3|Soluble Guanylate Cyclase 1A3|Soluble Guanylate Cyclase Alpha-3 Chain|Soluble Guanylate Cyclase Large Subunit	Encoded by human GUCY1A3 Gene (Adenylyl Cyclase 4/Guanylyl Cyclase Family), 690-aa 77-kDa cytoplasmic Soluble Guanylate Cyclase 1 Alpha 3 is a subunit of heterodimeric (alpha/beta) soluble guanylate cyclases, the main receptors for nitric oxide and nitrovasodilator drugs that catalyze conversion of GTP to cGMP second messenger. (NCI)
C38427	GUCY1B2_Gene	Protein_Complex_Subunit_Gene	GUCY1B2 Gene|GC-SB2|GUCY1B2|Guanylate Cyclase 1, Soluble, Beta 2 Gene	Human GUCY1B2 Gene (Adenylyl Cyclase 4/Guanylyl Cyclase Family) encodes 617-aa 70-kDa cytoplasmic Soluble Guanylate Cyclase 1 Beta 2, a subunit of heterodimeric (alpha/beta) soluble guanylate cyclases, the main receptors for nitric oxide in the cardiovascular system, and for nitrovasodilator drugs, that catalyze conversion of GTP to cGMP second messenger. (NCI)
C38428	Soluble_Guanylate_Cyclase-1-Beta-2	Protein_Complex_Subunit	Soluble Guanylate Cyclase 1 Beta 2|GCS-Beta-2|GUCY1B2|Soluble Guanylate Cyclase 1B2|Soluble Guanylate Cyclase Beta-2 Chain	Encoded by human GUCY1B2 Gene (Adenylyl Cyclase 4/Guanylyl Cyclase Family), 617-aa 70-kDa cytoplasmic Soluble Guanylate Cyclase 1 Beta 2 is a subunit of heterodimeric (alpha/beta) soluble guanylate cyclases, the main receptors for nitric oxide in the cardiovascular system, and for nitrovasodilator drugs, that catalyze conversion of GTP to cGMP second messenger. (NCI)
C38429	GUCY1B3_Gene	Protein_Complex_Subunit_Gene	GUCY1B3 Gene|GUC1B3|GUCB3|GUCSB3|GUCY1B1|GUCY1B3|Guanylate Cyclase 1, Soluble, Beta 3 Gene	Human GUCY1B3Gene (Adenylyl Cyclase 4/Guanylyl Cyclase Family) encodes 2 alternative isoforms of 619-aa 71-kDa cytoplasmic Soluble Guanylate Cyclase 1 Beta 3, a subunit of heterodimeric (alpha/beta) soluble guanylate cyclases, the main receptors for nitric oxide and for nitrovasodilator drugs, that catalyze conversion of GTP to cGMP second messenger. (NCI)
C38430	Soluble_Guanylate_Cyclase-1-Beta-3	Protein_Complex_Subunit	Soluble Guanylate Cyclase 1 Beta 3|GCS-Beta-1|GCS-Beta-3|GUCY1B3|Soluble Guanylate Cyclase 1B3|Soluble Guanylate Cyclase Beta-1 Chain|Soluble Guanylate Cyclase Small Subunit	Encoded by human GUCY1B3Gene (Adenylyl Cyclase 4/Guanylyl Cyclase Family) as 2 alternative isoforms, 619-aa 71-kDa cytoplasmic Soluble Guanylate Cyclase 1 Beta 3 is a subunit of heterodimeric (alpha/beta) soluble guanylate cyclases, the main receptors for nitric oxide and for nitrovasodilator drugs, that catalyze conversion of GTP to cGMP second messenger. (NCI)
C38431	UBB_Gene	Regulatory_Gene	UBB Gene|UBB|Ubiquitin B Gene	Consisting of 3 direct repeats of the ubiquitin coding sequence, human UBB Gene encodes highly conserved 76-aa 8.6-kDa nuclear and cytoplasmic Ubiquitin B, synthesized as a polyubiquitin precursor with head to tail repeats and involved in selective ATP-dependent nonlysosomal degradation of cellular proteins, histone modification, maintenance of chromatin structure, regulation of gene expression, stress response, and ribosome biogenesis. UBB appears to be covalently bound to proteins as a marker for degradation, but also binds to histone H2A in actively transcribed regions and does not cause histone H2A degradation; UBB may be involved in regulation of gene expression. Polyubiquitin genes comprise tandem ubiquitin repeats in the coding unit, while ubiquitin fusion genes encode a single ubiquitin fused to an unrelated tail protein. (NCI)
C38432	Ubiquitin-B	Ubiquitin	Ubiquitin B|Polyubiquitin B|UBB	Encoded by human UBB Gene, highly conserved 76-aa 8.6-kDa nuclear and cytoplasmic Ubiquitin B is synthesized as a polyubiquitin precursor with head to tail repeats and involved in selective ATP-dependent nonlysosomal degradation of cellular proteins, histone modification, maintenance of chromatin structure, regulation of gene expression, stress response, and ribosome biogenesis. UBB appears to be covalently bound to proteins as a marker for degradation, but also binds to histone H2A in actively transcribed regions and does not cause histone H2A degradation; UBB may be involved in regulation of gene expression. (NCI)
C38433	UBC_Gene	Regulatory_Gene	UBC Gene|HMG20|UBC|Ubiquitin C Gene	Consisting of 9 ubiquitin repeats in the coding sequence, human UBC Gene encodes highly conserved 76-aa 8.6-kDa nuclear and cytoplasmic Ubiquitin C, synthesized as a polyubiquitin precursor with head to tail repeats and involved in selective ATP-dependent nonlysosomal degradation of cellular proteins, histone modification, maintenance of chromatin structure, regulation of gene expression, stress response, and ribosome biogenesis. Ubiquitins typically appear to be covalently bound to proteins as a marker for degradation, but may participate in other cellular functions as well. Polyubiquitin genes comprise tandem ubiquitin repeats in the coding unit, while ubiquitin fusion genes encode a single ubiquitin fused to an unrelated tail protein. (NCI)
C38434	Peripheral_Post-Thymic_T-Lymphocyte	Peripheral_T-Lymphocyte_and_Natural_Killer_Cell|T-Lymphocyte	Peripheral (Post-Thymic) T-Lymphocyte
C38435	Ubiquitin-C	Ubiquitin	Ubiquitin C|UBC	Encoded by human UBC Gene, highly conserved 76-aa 8.6-kDa nuclear and cytoplasmic Ubiquitin C is synthesized as a polyubiquitin precursor with head to tail repeats and involved in selective ATP-dependent nonlysosomal degradation of cellular proteins, histone modification, maintenance of chromatin structure, regulation of gene expression, stress response, and ribosome biogenesis. Ubiquitins typically appear to be covalently bound to proteins as a marker for degradation, but may participate in other cellular functions as well. (NCI)
C38436	Mature_B-Lymphocyte_at_the_Germinal_Center_Stage_of_Differentiation	Mature_B-Lymphocyte	Mature B-Lymphocyte at the Germinal Center Stage of Differentiation	A mature naive B-lymphocyte in the germinal center of secondary lymphoid organ that has had contact with an antigen and a helper T-cell.
C38437	UBD_Gene	Gene_with_Unknown_or_Unclassified_Function	UBD Gene|UBD|Ubiquitin D Gene	Expressed in DCs, B cells, germinal center cells, and crypt epithelia (not in basal cells), single-copy human UBD Gene encodes 165-aa Ubiquitin D, containing 2 ubiquitin-like domains, each with 2 Cys residues. Ubiquitin family proteins have many roles, including nonspecific ligation of polypeptides and protein-protein dimerization. (NCI)
C38438	Ubiquitin-D	Protein_with_Unknown_or_Unclassified_Function	Ubiquitin D|Diubiquitin|FAT10|UBD	Expressed in DCs, B cells, germinal center cells, and crypt epithelia (not in basal cells) by single-copy human UBD Gene, 165-aa Ubiquitin D contains 2 ubiquitin-like domains, each with 2 Cys residues. Ubiquitin family proteins have many roles, including nonspecific ligation of polypeptides and protein-protein dimerization. (NCI)
C38439	Mature_Lymphocyte	Lymphocyte	Mature Lymphocyte	A white blood cell that matures in the primary lymphoid organs and then circulates through the lymph system to the secondary lymphoid tissues where it interacts with antigens. A mature lymphocyte varies in size from 7 to 15 micrometer in diameter and is round or ovoid, but may be notched or slightly indented. The chromatin is generally diffusely dense and nucleoli are not usually visible.
C38440	Abnormal_Immunology_Test_Result	Abnormal_Laboratory_Test	Abnormal Immunology Test Result
C38441	Interleukin-2_Overexpression	Abnormal_Immunology_Test_Result	Interleukin-2 Overexpression|IL-2 Overexpression
C38442	Interleukin-5_Overexpression	Abnormal_Immunology_Test_Result	Interleukin-5 Overexpression|IL-5 Overexpression
C38443	Interleukin-6_Overexpression	Abnormal_Immunology_Test_Result	Interleukin-6 Overexpression|IL-6 Overexpression
C38444	Interleukin-7_Overexpression	Abnormal_Immunology_Test_Result	Interleukin-7 Overexpression|IL-7 Overexpression
C38445	Interleukin-9_Overexpression	Abnormal_Immunology_Test_Result	Interleukin-9 Overexpression|IL-9 Overexpression
C38446	Interleukin-10_Overexpression	Abnormal_Immunology_Test_Result	Interleukin-10 Overexpression|IL-10 Overexpression
C38447	Interleukin-13_Overexpression	Abnormal_Immunology_Test_Result	Interleukin-13 Overexpression|IL-13 Overexpression
C38448	Lymphotoxin-Alpha_Overexpression	Abnormal_Immunology_Test_Result	Lymphotoxin-Alpha Overexpression
C38450	Colony-Stimulating_Factor_Overexpression	Abnormal_Immunology_Test_Result	Colony-Stimulating Factor Overexpression
C38452	Peer_Pressure	Societal_Factors	Peer Pressure	Peer pressure comprises a set of group dynamics whereby a group in which one feels comfortable may override personal habits, individual moral inhibitions or idiosyncratic desires to impose a group norm of attitudes and/or behaviors. (from Wikipedia)
C38457	Clonal_BCL-3_Gene_Rearrangement	Clonal_Gene_Rearrangement	Clonal BCL3 Gene Rearrangement|Clonal BCL-3 Gene Rearrangement
C38458	Serrated_Adenoma	Adenomatous_Polyp	Serrated Adenoma
C38459	AP12-MLT_Fusion_Protein_Expression	Fusion_Protein_Expression	AP12-MLT Fusion Protein Expression
C38460	del_11q24	Chromosomal_Deletion	del(11q24)
C38461	Caspase_Inhibitor	Enzyme_Inhibitor	Caspase Inhibitor
C38462	Partial_Thromboplastin_Time_Test	Test|Test_Generic	Partial Thromboplastin Time|Activated Partial Thromboplastin Time|PTT|aPTT	This is a measurement of the intrinsic pathway of coagulation. Significant deficiency in factors II, V, VIII, IX, X, XI, XII or anticoagulants will prolong PTT. (BioTech Life Science Dictionary)
C38465	Hair_Part	Integumentary_System_Part	Hair Part
C38466	Lymph_Node_Part	Immune_System_Part	Lymph Node Part
C38467	Interfollicular_Area_of_the_Lymph_Node	Lymph_Node_Part	Interfollicular Area of the Lymph Node|Lymph Node Paracortex|Lymph Node Paracortical Region
C38468	_5-Hydroxypicolinaldehyde_Thiosemicarbazone	Pyrimidine_Antagonist|Ribonucleotide_Reductase_Inhibitor	5-Hydroxypicolinaldehyde Thiosemicarbazone|5-HP	A thiosemicarbazone antimetabolite. A derivative of 5-hydroxypicolinaldehyde, 5-HP inhibits DNA polymerase, resulting in the inhibition of DNA replication and cell death. (NCI04)
C38469	Constitutional_Symptom	Symptom	Constitutional Symptom|Constitutional Finding|Constitutional Findings
C38470	Lab_Finding	Test_Result	Laboratory Finding|Lab Findings|Labs	The result of a lab test to measure an attribute or to determine the presence, absence or degree of a condition.
C38471	Commercial_or_Non-CTEP_IND_Agents	Clinical_Study_Element	Commercial or Non-CTEP IND Agent
C38472	_2p15	Chromosome_Band	2p15	A chromosome band present on 2p
C38473	_3q26_2-qter	Chromosome_Band	3q26.2-qter	A chromosome band present on 3q
C38474	_3q27_3	Chromosome_Band	3q27.3	A chromosome band present on 3q
C38475	_4q21-q24	Chromosome_Band	4q21-q24	A chromosome band present on 4q
C38476	_8p21_2	Chromosome_Band	8p21.2	A chromosome band present on 8p
C38477	_9q31_1	Chromosome_Band	9q31.1	A chromosome band present on 9q
C38478	_9pter-p22_1	Chromosome_Band	9pter-p22.1	A chromosome band present on 9p
C38479	_10q24_1-q25_1	Chromosome_Band	10q24.1-q25.1	A chromosome band present on 10q
C38480	_10q21-q22	Chromosome_Band	10q21-q22	A chromosome band present on 10q
C38481	_12q24_2-q24_31	Chromosome_Band	12q24.2-q24.31	A chromosome band present on 12q
C38482	_16q12_1	Chromosome_Band	16q12.1	A chromosome band present on 16q
C38483	_16q22-q23_1	Chromosome_Band	16q22-q23.1	A chromosome band present on 16q
C38484	_17q23_2-q25_3	Chromosome_Band	17q23.2-q25.3	A chromosome band present on 17q
C38485	_17p13_1-q25	Chromosome_Band	17p13.1-q25	A chromosome band present on 17p
C38486	Micrometastasis_Finding	Morphologic_Finding	Micrometastasis|MICMET|Micrometastases|Micromets|micrometastases	Small numbers of cancer cells that have spread from the primary tumor to other parts of the body and are too few to be picked up in a screening or diagnostic test.
C38487	TUBG1_Gene	Cytoskeletal_Gene	TUBG1 Gene|TUBG|TUBG1|Tubulin, Gamma 1 Gene	Expressed most in prophase through metaphase, during maximal microtubule assembly from centrosomes, human TUBG1 Gene (Tubulin Family) encodes ubiquitous and highly conserved 451-aa 51-kDa Gamma Tubulin 1, a component of microtubule organizing centers such as spindle poles or pericentriolar microtubule-nucleating material of centrosomes that interacts with GCP2 and GCP3 and may be involved in minus-end nucleation of microtubule assembly. (NCI)
C38488	Gamma_Tubulin-1	Gamma-Tubulin	Gamma Tubulin 1|GCP-1|Gamma Tubulin Polypeptide|Gamma-1 Tubulin|Gamma-Tubulin Complex Component 1|TUBG1|Tubulin Gamma 1|Tubulin Gamma-1 Chain	Expressed most in prophase through metaphase, during maximal microtubule assembly from centrosomes, by human TUBG1 Gene (Tubulin Family), ubiquitous and highly conserved 451-aa 51-kDa Gamma Tubulin 1 is a component of microtubule organizing centers such as spindle poles or pericentriolar microtubule-nucleating material of centrosomes that interacts with GCP2 and GCP3 and may be involved in minus-end nucleation of microtubule assembly. (NCI)
C38489	TUBG2_Gene	Cytoskeletal_Gene	TUBG2 Gene|TUBG2|Tubulin, Gamma 2 Gene	Widely expressed like TUBG1, human TUBG2 Gene (Tubulin Family) encodes 451-aa 51-kDa Gamma Tubulin 2, an essential component of microtubule organizing centers such as spindle poles or centrosomes, with 97.3% sequence identity to TUBG1, and likely involved in minus-end nucleation of microtubule assembly. (NCI)
C38490	Gamma_Tubulin-2	Gamma-Tubulin	Gamma Tubulin 2|Gamma-2 Tubulin|TUBG2|Tubulin Gamma 2|Tubulin Gamma-2 Chain	Widely expressed like TUBG1 by human TUBG2 Gene (Tubulin Family), 451-aa 51-kDa Gamma Tubulin 2 is an essential component of microtubule organizing centers such as spindle poles or centrosomes, with 97.3% sequence identity to TUBG1, and likely involved in minus-end nucleation of microtubule assembly. (NCI)
C38491	GNRH1_Gene	Peptide_Hormone_Gene	GNRH1 Gene|GNRH|GNRH1|GRH|Gonadotropin-Releasing Hormone 1 (Luteinizing-Releasing Hormone) Gene|LHRH|LNRH	Specifically expressed in a small population of hypothalamic neurons, 4-exon human GNRH1 Gene (GnRH Family) encodes a 92-aa 10-kDa precursor of PIF and Gonadotropin Releasing Hormone 1, a hormone secreted into the median eminence capillary plexus that stimulates release of LHRH and FSH from anterior pituitary gonadotropes to control female reproduction. GNRH1 expression is regulated by specific upstream promoter binding elements: GATA transcription factors act through tandem GATA-A and GATA-B enhancer motifs; GBF-A1/A2 and GBF-B1 factors bind at GATA-motif overlapping sites; and OCT1 (critical in GNRH1 transcription) binds distal enhancer and proximal promoter elements. (NCI)
C38492	Gonadotrophin_Releasing_Hormone-1	Gonadotrophin_Releasing_Hormone	Gonadotropin Releasing Hormone 1|GNRH1|GnRH I|GnRH-Associated Peptide I|Gonadoliberin I|Gonadorelin|LH-RH I|Leutinizing-Releasing Hormone|Luliberin I|Luteinizing Hormone-Releasing Hormone I|Progonadoliberin I	Specifically expressed as a 92-aa 10-kDa precursor in a small population of hypothalamic neurons by human GNRH1 Gene (GnRH Family), Gonadotropin Releasing Hormone 1 is secreted into the median eminence capillary plexus and stimulates release of LHRH and FSH from anterior pituitary gonadotropes to control female reproduction. (NCI)
C38493	GNRH2_Gene	Peptide_Hormone_Gene	GNRH2 Gene|GNRH2|Gonadotropin-Releasing Hormone 2 Gene	Expressed in the midbrain, and at higher levels in the kidney, bone marrow, and prostate, human GNRH2 Gene (GnRH Family) encodes a preproprotein cleaved to form Gonadotropin Releasing Hormone 2, a secreted decapeptide hormone that stimulates secretion of LHRH and FSH gonadotropins from anterior pituitary gonadotropes to control female reproduction. Three transcript variants appear to encode unique proproteins that contain the same peptide hormone. (NCI)
C38494	Gonadotrophin_Releasing_Hormone-2	Gonadotrophin_Releasing_Hormone	Gonadotropin Releasing Hormone 2|GNRH2|GnRH II|GnRH-Associated Peptide II|GnRH-II|Gonadoliberin II|Gonadotropin-Releasing Hormone 2|Gonadotropin-Releasing Hormone II|LH-RH II|LH-RHII|Luliberin II|Luteinizing Hormone-Releasing Hormone II|Progonadoliberin II	Expressed as preproprotein in the midbrain, and at higher levels in the kidney, bone marrow, and prostate, by human GNRH2 Gene (GnRH Family), secreted decapeptide Gonadotropin Releasing Hormone 2 stimulates secretion of LHRH and FSH gonadotropins from anterior pituitary gonadotropes to control female reproduction. (NCI)
C38495	HPRT1_Gene	Glycosyltransferase_Gene	HPRT1 Gene|HGPRT|HPRT|HPRT1|Hypoxanthine Phosphoribosyltransferase 1 (Lesch-Nyhan Syndrome) Gene	The 9-exon 44-kb human HPRT1 Gene (Purine/Pyrimidine Phosphoribosyltransferase Family) encodes 217-aa 24-kDa homotetrameric cytoplasmic Hypoxanthine Phosphoribosyltransferase 1, involved in purine salvage. HPRT1 defects cause Lesch-Nyhan syndrome or gout. (NCI)
C38496	Hypoxanthine_Phosphoribosyltransferase-1	Hypoxanthine_Phosphoribosyltransferase	Hypoxanthine Phosphoribosyltransferase 1|HGPRT|HGPRTase|HPRT1|Hypoxanthine-Guanine Phosphoribosyltransferase	Encoded by human HPRT1 Gene (Purine/Pyrimidine Phosphoribosyltransferase Family), 217-aa 24-kDa homotetrameric cytoplasmic Hypoxanthine Phosphoribosyltransferase 1 is involved in purine salvage. HPRT1 defects cause Lesch-Nyhan syndrome or gout. (NCI)
C38497	HPRT2_Gene	Glycosyltransferase_Gene	HPRT2 Gene|HPRT2|Hypoxanthine Phosphoribosyltransferase 2 Gene
C38498	Hypoxanthine_Phosphoribosyltransferase-2	Hypoxanthine_Phosphoribosyltransferase	Hypoxanthine Phosphoribosyltransferase 2|HPRT2
C38499	GOT1_Gene	Transferase_Gene	GOT1 Gene|GOT1|Glutamic-Oxaloacetic Transaminase 1, Soluble (Aspartate Aminotransferase 1) Gene	Human GOT1 Gene (Class-I Pyridoxal-Phosphate-Dependent Aminotransferase Family) encodes 412-aa 46-kDa homodimeric cytoplasmic Aspartate Aminotransferase 1, a pyridoxal phosphate-dependent enzyme similar to mitochondrial GOT2 and involved in both amino acid metabolism and the urea and tricarboxylic acid cycles. (NCI)
C38500	Aspartate_Aminotransferase-1	SGOT-AST_Protein	Aspartate Aminotransferase 1|Cytoplasmic Aspartate Aminotransferase|GOT1|Glutamate Oxaloacetate Transaminase-1|Soluble Glutamic-Oxaloacetic Transaminase 1|Transaminase A	Encoded by human GOT1 Gene (Class-I Pyridoxal-Phosphate-Dependent Aminotransferase Family), 412-aa 46-kDa homodimeric cytoplasmic Aspartate Aminotransferase 1 is a pyridoxal phosphate-dependent enzyme similar to mitochondrial GOT2 and involved in both amino acid metabolism and the urea and tricarboxylic acid cycles. (NCI)
C38501	GOT2_Gene	Transferase_Gene	GOT2 Gene|GOT2|Glutamic-Oxaloacetic Transaminase 2, Mitochondrial (Aspartate Aminotransferase 2) Gene	Human GOT2 Gene (Class-I Pyridoxal-Phosphate-Dependent Aminotransferase Family) encodes 430-aa 47-kDa homodimeric Aspartate Aminotransferase 2, a pyridoxal phosphate-dependent enzyme of the inner mitochondrial membrane or matrix, similar to cytoplasmic GOT1, and involved in both amino acid metabolism and the urea and tricarboxylic acid cycles. (NCI)
C38502	Aspartate_Aminotransferase-2	SGOT-AST_Protein	Aspartate Aminotransferase 2|GOT2|Glutamate Oxaloacetate Transaminase-2|Mitochondrial Aspartate Aminotransferase|Mitochondrial Glutamic-Oxaloacetic Transaminase 2|Transaminase A	Encoded by human GOT2 Gene (Class-I Pyridoxal-Phosphate-Dependent Aminotransferase Family), 430-aa 47-kDa homodimeric Aspartate Aminotransferase 2 is a pyridoxal phosphate-dependent enzyme of the inner mitochondrial membrane or matrix, similar to cytoplasmic GOT1, and involved in both amino acid metabolism and the urea and tricarboxylic acid cycles. (NCI)
C38503	GPT_Gene	Transferase_Gene	GPT Gene|AAT1|GPT|GPT1	Induced by glucocorticoids and expressed (2-kb mRNA) in liver, kidney, heart, fat, and skeletal muscle, 3-kb 11-exon human GPT Gene (Alanine Aminotransferase Family) encodes 495-aa 54-kDa Glutamic-Pyruvate Transaminase, a homodimeric cytoplasmic pyridoxal phosphate-dependent enzyme involved in cellular nitrogen metabolism, amino acid metabolism, and liver gluconeogenesis. GPT mediates conversion of major intermediate metabolites, catalyzing reversible transamination between alanine and alpha-ketoglutarate to form pyruvate and glutamate. (NCI)
C38504	Microscopic_Colitis	Colitis	Microscopic Colitis
C38507	Glutamic-Pyruvate_Transaminase	SGPT-ALT_Protein	Glutamic-Pyruvate Transaminase|AAT1|ALT1|Alanine Aminotransferase|GPT|GPT1|Glutamic-Alanine Transaminase|Glutamic-Pyruvic Transaminase	Expressed in liver, kidney, heart, fat, and skeletal muscle by glucocorticoid-induced human GPT Gene (Alanine Aminotransferase Family), 495-aa 54-kDa Glutamic-Pyruvate Transaminase is a homodimeric cytoplasmic pyridoxal phosphate-dependent enzyme involved in cellular nitrogen metabolism, amino acid metabolism, and liver gluconeogenesis. GPT mediates conversion of major intermediate metabolites, catalyzing reversible transamination between alanine and alpha-ketoglutarate to form pyruvate and glutamate. (NCI)
C38508	GPT2_Gene	Transferase_Gene	GPT2 Gene|ALT2|GPT2|Glutamic Pyruvate Transaminase (Alanine Aminotransferase) 2 Gene	Expressed (4-kb mRNA) in muscle, fat, kidney, brain, liver, and breast, 50-kb 12-exon human GPT2 Gene (Alanine Aminotransferase Family) encodes 523-aa 58-kDa Glutamic-Pyruvate Transaminase 2, a mitochondrial pyridoxal phosphate-dependent enzyme involved in cellular nitrogen metabolism, amino acid metabolism, and gluconeogenesis. Sharing 69% identity with GPT, GPT2 contains a complete transaminase class I domain and a partial transaminase class II domain. GPT2 mediates conversion of major intermediate metabolites, catalyzing reversible transamination between alanine and alpha-ketoglutarate to form pyruvate and glutamate. (NCI)
C38509	Glutamic-Pyruvate_Transaminase-2	SGPT-ALT_Protein	Glutamic-Pyruvate Transaminase 2|ALT2|Alanine Aminotransferase 2|GPT2	Expressed in muscle, fat, kidney, brain, liver, and breast by human GPT2 Gene (Alanine Aminotransferase Family), 523-aa 58-kDa Glutamic-Pyruvate Transaminase 2 is a mitochondrial pyridoxal phosphate-dependent enzyme involved in cellular nitrogen metabolism, amino acid metabolism, and gluconeogenesis. Sharing 69% identity with GPT, GPT2 contains a complete transaminase class I domain and a partial transaminase class II domain. GPT2 mediates conversion of major intermediate metabolites, catalyzing reversible transamination between alanine and alpha-ketoglutarate to form pyruvate and glutamate. (NCI)
C38510	Spleen_Part	Immune_System_Part	Spleen Part
C38511	TK1_Gene	Kinase_Family_Gene	TK1 Gene|TK1|Thymidine Kinase 1, Soluble Gene	Maximally expressed like PCNA at the G1/S cell cycle boundary, 13-kb 7-exon human TK1 Gene (Thymidine Kinase Family) encodes conserved 234-aa 25-kDa cytoplasmic Thymidine Kinase 1: phosphorylated (Ser13) in mitosis, peak activity in S-phase, and catalyzes thymidine phosphorylation to deoxythymidine monophosphate. (NCI)
C38512	Thymidine_Kinase-1	Thymidine_Kinase	Thymidine Kinase 1|Cytosolic Thymidine Kinase|Soluble Thymidine Kinase 1|TK1	Maximally expressed like PCNA at the G1/S cell cycle boundary by human TK1 Gene (Thymidine Kinase Family), conserved 234-aa 25-kDa cytoplasmic Thymidine Kinase 1 is phosphorylated (Ser13) in mitosis, has peak activity in S-phase, and catalyzes thymidine phosphorylation to deoxythymidine monophosphate. (NCI)
C38513	Thymidine_Kinase-2	Thymidine_Kinase	Thymidine Kinase 2|Mitochondrial Thymidine Kinase 2|Mt-TK|TK2	Expressed (as long 266-aa 31-kDa precursor and short 235-aa alternative isoforms) predominantly in liver, pancreas, muscle, and brain by human TK2 Gene (DCK/DGK Family), Thymidine Kinase 2 is a monomeric mitochondrial deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, as well as anti-viral and anti-cancer nucleoside analogs. In nonreplicating cells, mtDNA synthesis depends on 2 salvage pathway deoxyribonucleoside kinases, DGK and Thymidine Kinase 2. Separated from cytosolic dNTPs by the mitochondria inner membrane, mitochondrial dNTPs are maintained by transporter import or deoxynucleoside salvaging; de novo dNTP synthetic enzymes appear not to be present in mitochondria. (NCI)
C38514	TK2_Gene	Kinase_Family_Gene	TK2 Gene|TK2|Thymidine Kinase 2, Mitochondrial Gene	Expressed (as long 266-aa 31-kDa precursor and short 235-aa alternative isoforms) predominantly in liver, pancreas, muscle, and brain, human TK2 Gene (DCK/DGK Family) encodes Thymidine Kinase 2, a monomeric mitochondrial deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, as well as anti-viral and anti-cancer nucleoside analogs. In nonreplicating cells, mtDNA synthesis depends on 2 salvage pathway deoxyribonucleoside kinases, DGK and Thymidine Kinase 2. Separated from cytosolic dNTPs by the mitochondria inner membrane, mitochondrial dNTPs are maintained by transporter import or deoxynucleoside salvaging; de novo dNTP synthetic enzymes appear not to be present in mitochondria. (NCI)
C38515	Thymic_Lymphoid_Tissue	Lymphoid_Tissue|Thymic_Tissue	Thymic Lymphoid Tissue	The lymphoid tissue of the thymus in which T cell maturation occurs.
C38516	Tonsilar_Tissue	Tissue|Tonsil_Part	Tonsillar Tissue
C38517	TFRC_Gene	Receptor_Gene	TFRC Gene|CD71|TFR|TFRC|TRFR	Regulated by mitogenic stimulation and cellular iron levels (through IRP1/2), TFRC Gene (M28B Peptidase Family) encodes 760-aa 85-kDa Transferrin Receptor 1, a glycosylated, phosphorylated, and palmitoylated type II membrane disulfide-linked homodimeric glycoprotein involved in cellular uptake of iron via receptor-mediated endocytosis. After intracellular iron release, apotransferrin-receptor is recycled to the cell surface with release of apotransferrin. Transferrin receptor appears necessary for nervous system and erythrocyte development, binds HLA class II histocompatibility antigen DR1, and binds parvoviruses that enter and infect cells. Ligand HFE competes with transferrin for binding to an overlapping C-terminal site. Proteolytic cleavage at Arg100 produces the glycosylated secreted sTfR isoform; used in a diagnostic test for anemia. (NCI)
C38518	Tonsillar_Lymphoid_Tissue	Lymphoid_Tissue|Tonsilar_Tissue	Tonsillar Lymphoid Tissue	Lymphoid tissue of the tonsils. It is composed of B and T lymphocytes. Lymphoid follicles with germinal centers occupy the areas that are populated with B lymphocytes.
C38519	Transferrin_Receptor-1	Transferrin_Receptor	Transferrin Receptor 1|CD71|CD71 Antigen|T9|TFR|TFR1|TFRC|TR|TRFR|Transferrin Receptor|Transferrin Receptor Protein 1|p90	Regulated by mitogenic stimulation and cellular iron levels (through IRP1/2), TFRC Gene (M28B Peptidase Family) encodes 760-aa 85-kDa Transferrin Receptor 1, a glycosylated, phosphorylated, and palmitoylated type II membrane disulfide-linked homodimeric glycoprotein involved in cellular uptake of iron via receptor-mediated endocytosis. After intracellular iron release, apotransferrin-receptor is recycled to the cell surface with release of apotransferrin. Transferrin receptor appears necessary for nervous system and erythrocyte development, binds HLA class II histocompatibility antigen DR1, and binds parvoviruses that enter and infect cells. Ligand HFE competes with transferrin for binding to an overlapping C-terminal site. Proteolytic cleavage at Arg100 produces the glycosylated secreted sTfR isoform; used in a diagnostic test for anemia. (NCI)
C38520	TFR2_Gene	Receptor_Gene	TFR2 Gene|HFE3|TFR2|Transferrin Receptor 2 Gene	Widely expressed human TFR2 Gene (M28B Peptidase Family) encodes alpha, beta, and gamma isoforms of homodimeric Transferrin Receptor 2, a second transferrin receptor that mediates cellular transport of transferrin-bound iron, in a non-iron dependent manner, and may be involved in iron metabolism, hepatocyte function, and erythrocyte differentiation. A 801-aa type II membrane protein, the alpha form (18 exons) has 45% identity and 66% similarity in its extracellular domain with TFRC. An alternative splicing or promoter product with altered exon 4, the beta form lacks the N-terminal portion (exons 1-3 absent), including the transmembrane domain. TFR2 defects cause HFE3. A Lys172 variant in HFE3 affects the putative initiation codon of the beta isoform, preventing translation. (NCI)
C38521	Transferrin_Receptor-2	Transferrin_Receptor	Transferrin Receptor 2|TFR2|Transferrin Receptor Protein 2	Human transferrin protein (698 aa, 77 kDa precursor) is encoded by the human transferrin (TF) gene. The protein is a serum beta-globulin glycoprotein that binds one ferric iron atom to homologous C- and N-terminal domains. Transferrin transports iron from the intestine, reticuloendothelial system, and liver parenchyma to all proliferating cells.
C38522	PPP3CA_Gene	Protein_Serine-Threonine_Phosphatase_Gene	PPP3CA Gene|CALN|CALNA|CALNA1|CCN1|CNA|CNA1|PPP2B|PPP3CA	Human PPP3CA Gene (PPP Phosphatase/PP-2B Family) encodes 521-aa 59-kDa Calcineurin A Alpha, a calmodulin-binding catalytic subunit of ubiquitous heterodimeric Ca(2+)/calmodulin-regulated protein phosphatase Calcineurin involved in many biologic activities as a modifier of phosphorylation status. Calcineurin catalytic subunits are derived from alternatively spliced highly conserved PPP3CA, PPP3CB, PPP3CC genes. IGF1 stimulates a myocyte switch to glycolytic metabolism by activating calcineurin A, inducing nuclear translocation of NFATC1 transcription factor, and association of calcineurin, GATA2, and dephosphorylated NFATC1. DSCR1 interacts with calcineurin A in the linker region between the catalytic domain and the calcineurin B-binding domain. DSCR1 and ZAKI4 may inhibit calcineurin-dependent gene transcription through inhibition of NFAT translocation to the nucleus. (NCI)
C38523	Calcineurin-A_Alpha	Protein_Complex_Subunit	Calcineurin A Alpha|CAM-PRP Catalytic Subunit|Calmodulin-Dependent Calcineurin A Subunit Alpha Isoform|PPP3CA|Protein Phosphatase 3 Catalytic Subunit Alpha Isoform|Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Alpha Isoform	Encoded by human PPP3CA Gene (PPP Phosphatase/PP-2B Family), 521-aa 59-kDa Calcineurin A Alpha is a calmodulin-binding catalytic subunit of ubiquitous heterodimeric Ca(2+)/calmodulin-regulated protein phosphatase Calcineurin involved in many biologic activities as a modifier of phosphorylation status. Calcineurin catalytic subunits are derived from alternatively spliced highly conserved PPP3CA, PPP3CB, PPP3CC genes. IGF1 stimulates a myocyte switch to glycolytic metabolism by activating calcineurin A, inducing nuclear translocation of NFATC1 transcription factor, and association of calcineurin, GATA2, and dephosphorylated NFATC1. DSCR1 interacts with calcineurin A in the linker region between the catalytic domain and the calcineurin B-binding domain. DSCR1 and ZAKI4 may inhibit calcineurin-dependent gene transcription through inhibition of NFAT translocation to the nucleus. (NCI)
C38524	PPP3CB_Gene	Protein_Serine-Threonine_Phosphatase_Gene	PPP3CB Gene|CALNA2|CALNB|CNA2|PPP3CB	Human PPP3CB Gene (PPP Phosphatase/PP-2B Family) encodes 510-aa Calcineurin A Beta, a brain calmodulin-binding catalytic subunit of ubiquitous heterodimeric Ca(2+)/calmodulin-regulated protein phosphatase Calcineurin. Calcineurin catalytic subunits are derived from alternatively spliced highly conserved PPP3CA, PPP3CB, PPP3CC genes. Activated PPP3CB appears involved in dopaminergic signal transduction and in some glutamatergic NMDA receptor-dependent synaptic plasticity. (NCI)
C38525	Calcineurin-A_Beta	Protein_Complex_Subunit	Calcineurin A Beta|CAM-PRP Catalytic Subunit|Calmodulin-Dependent Calcineurin A Subunit Beta Isoform|PPP3CB|Protein Phosphatase 3 Catalytic Subunit Beta Isoform|Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Beta Isoform	Encoded by human PPP3CB Gene (PPP Phosphatase/PP-2B Family), 510-aa Calcineurin A Beta is a brain calmodulin-binding catalytic subunit of ubiquitous heterodimeric Ca(2+)/calmodulin-regulated protein phosphatase Calcineurin. Calcineurin catalytic subunits are derived from alternatively spliced highly conserved PPP3CA, PPP3CB, PPP3CC genes. Activated PPP3CB appears involved in dopaminergic signal transduction and in some glutamatergic NMDA receptor-dependent synaptic plasticity. (NCI)
C38526	PPP3CC_Gene	Protein_Serine-Threonine_Phosphatase_Gene	PPP3CC Gene|CALNA3|CNA3|PPP3CC	Human PPP3CC Gene (PPP Phosphatase/PP-2B Family) encodes 502-aa 57-kDa Calcineurin A Gamma, a testicular calmodulin-binding catalytic subunit of ubiquitous heterodimeric Ca(2+)/calmodulin-regulated protein phosphatase Calcineurin involved in many biologic activities as a modifier of phosphorylation status. Calcineurin catalytic subunits are derived from alternatively spliced highly conserved PPP3CA, PPP3CB, PPP3CC genes. PPP3CC may be associated with the flagellum and regulate sperm motility. (NCI)
C38527	Calcineurin-A_Gamma	Protein_Complex_Subunit	Calcineurin A Gamma|CAM-PRP Catalytic Subunit|Calmodulin-Dependent Calcineurin A Subunit Gamma Isoform|PPP3CC|Protein Phosphatase 3 Catalytic Subunit Gamma Isoform|Serine/Threonine Protein Phosphatase 2B Catalytic Subunit Gamma Isoform|Testis-Specific Calcineurin Catalytic Subunit	Encoded by human PPP3CC Gene (PPP Phosphatase/PP-2B Family), 502-aa 57-kDa Calcineurin A Gamma is a testicular calmodulin-binding catalytic subunit of ubiquitous heterodimeric Ca(2+)/calmodulin-regulated protein phosphatase Calcineurin involved in many biologic activities as a modifier of phosphorylation status. Calcineurin catalytic subunits are derived from alternatively spliced highly conserved PPP3CA, PPP3CB, PPP3CC genes. PPP3CC may be associated with the flagellum and regulate sperm motility. (NCI)
C38528	PPP3R1_Gene	Regulatory_Gene	PPP3R1 Gene|CALNB1|CNA2|CNB|CNB1|PPP3R1|Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, 19kDa, Alpha Isoform (Calcineurin B, Type I) Gene	Expressed in all tissues as 2 alternative isoforms (isoform 2, testis-specific), human PPP3R1 Gene encodes highly conserved 19-kD Calcineurin B Type I, a Ca(2+)-sensitive regulatory subunit (containing 4 EF-hand calcium-binding domains) of ubiquitous heterodimeric Ca(2+)/calmodulin-regulated protein phosphatase Calcineurin involved in many biologic signaling activities as a modifier of phosphorylation status. (NCI)
C38529	Calcineurin-B_Type-I	Protein_Complex_Subunit	Calcineurin B Type I|Calcineurin B Subunit Isoform 1|PPP3R1|Protein Phosphatase 2B Regulatory Subunit 1|Protein Phosphatase 3 Regulatory Subunit B 19-kDa Alpha Isoform|Protein Phosphatase 3 Regulatory Subunit B Alpha Isoform 1	Expressed in all tissues by human PPP3R1 Gene as 2 alternative isoforms (isoform 2, testis-specific), highly conserved 19-kD Calcineurin B Type I is a Ca(2+)-sensitive regulatory subunit (containing 4 EF-hand calcium-binding domains) of ubiquitous heterodimeric Ca(2+)/calmodulin-regulated protein phosphatase Calcineurin involved in many biologic signaling activities as a modifier of phosphorylation status. (NCI)
C38530	PPP3R2_Gene	Gene_with_Unknown_or_Unclassified_Function	PPP3R2 Gene|PPP3R2|Protein Phosphatase 3 (Formerly 2B), Regulatory Subunit B, 19kDa, Beta Isoform (Calcineurin B, Type II) Gene
C38531	Calcineurin-B_Type-II	Protein_Complex_Subunit	Calcineurin B Type II|CBLP-Like Protein|PPP3R2|Protein Phosphatase 3 Regulatory Subunit B19-kDa Beta Isoform
C38533	Sight	Sensory_Process	Sight	Sight; the faculty of vision, the perception of objects by the eye.
C38534	CREB_Family_Gene	Transcription_Factor_Gene	CREB Family Gene	Ubiquitously or widely expressed human CREB Family Genes (bZIP/CREB Family) encode conserved cAMP Responsive Element Binding Proteins, nuclear bZIP domain dimeric transcription factors that bind to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induce gene transcription in response to cAMP signaling pathways. CREB proteins bind to DNA as a homodimer or a heterodimer with JUN/c-Jun or ATF2/CREBP1. Increased cAMP levels following stimulation activate cAMP-dependent protein kinase A, which phosphorylates CREB proteins that stimulate transcription of cAMP-responsive genes.  Calcium-regulated CREB transcription factors integrate calcium and cAMP signals.  cAMP pathways provide a chief means by which cellular growth, differentiation, and function can be influenced by extracellular signals. (NCI)
C38535	Touch	Sensory_Process	Touch	Touch; the faculty of touch, the sensation produced by pressure receptors in the skin.
C38536	CREB1_Gene	CREB_Family_Gene	CREB1 Gene|CREB|CREB1|cAMP Cesponsive Element Binding Protein 1 Gene	Human CREB1 Gene (bZIP/CREB Family) encodes alternative A, B isoforms of nuclear cAMP Responsive Element Binding Protein 1, a homodimeric transcription factor containing 1 KID domain, phosphorylated/stimulated by several protein kinases, that binds to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induces gene transcription in response to hormonal stimulation of the cAMP pathway. (NCI)
C38537	cAMP_Responsive_Element_Binding_Protein-1	cAMP_Responsive_Element_Binding_Protein	cAMP Responsive Element Binding Protein 1|Active Transcription Factor CREB|CREB1|Transactivator Protein	Encoded as alternative A, B isoforms by human CREB1 Gene (bZIP/CREB Family), nuclear cAMP Responsive Element Binding Protein 1 is a homodimeric transcription factor containing 1 KID domain, phosphorylated/stimulated by several protein kinases, that binds to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and induces gene transcription in response to hormonal stimulation of the cAMP pathway. (NCI)
C38538	CREB3_Gene	CREB_Family_Gene	CREB3 Gene|CREB3|LUMAN|LZIP|cAMP Responsive Element Binding Protein 3 Gene	Human CREB3 Gene (bZIP/CREB Family) encodes (1.4-kb mRNA) ubiquitous 371-aa cAMP Responsive Element Binding Protein 3, a conserved transcription factor that binds to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters; possesses an acidic Glu-rich N-terminal transcription activation domain, a Ser-rich region, a central bZIP domain, and a Pro-rich C-terminal region; and interacts with conserved HCFC1 and OCT1. Cytoplasmic CREB3 is colocalized with ER-associated Calnexin. CREB3 and HSV VP16 protein bind the same HCFC1 site. CREB3-HCFC1 release permits VP16-induced transcription of HSV immediate-early genes by association with OCT1, stabilized by interaction with the interacting HCFC1 N- and C-termini. HCV core protein C terminus interacts with the CREB3 bZIP domain and prevents nuclear CREB3 dimer formation. (NCI)
C38539	cAMP_Responsive_Element_Binding_Protein-3	cAMP_Responsive_Element_Binding_Protein	cAMP Responsive Element Binding Protein 3|Basic Leucine Zipper Protein|Basic Leucine Zipper Protein LZIP|CREB3|Cyclic AMP Response Element (CRE)-Binding Protein/Activating Transcription Factor 1|Luman|Transcription Factor LZIP-Alpha	Encoded by human CREB3 Gene (bZIP/CREB Family), ubiquitous 371-aa cAMP Responsive Element Binding Protein 3 is a conserved transcription factor that binds to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters; possesses an acidic Glu-rich N-terminal transcription activation domain, a Ser-rich region, a central bZIP domain, and a Pro-rich C-terminal region; and interacts with conserved HCFC1 and OCT1. Cytoplasmic CREB3 is colocalized with ER-associated Calnexin. CREB3 and HSV VP16 protein bind the same HCFC1 site. CREB3-HCFC1 release permits VP16-induced transcription of HSV immediate-early genes by association with OCT1, stabilized by interaction with the interacting HCFC1 N- and C-termini. HCV core protein C terminus interacts with the CREB3 bZIP domain and prevents nuclear CREB3 dimer formation. (NCI)
C38540	CREB4_Gene	CREB_Family_Gene	CREB4 Gene|CREB4|cAMP Responsive Element Binding Protein 1 Gene	Expressed in prostate, brain, pancreas, skeletal muscle, small intestine, testis, leukocytes, and thymus, 10-exon human CREB4 Gene (bZIP/CREB Family) encodes 395-aa cAMP Responsive Element Binding Protein 4, a transcription factor with a basic leucine zipper region that binds to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters. CREB4 has 62% identity with mouse Creb3. (NCI)
C38541	cAMP_Responsive_Element_Binding_Protein-4	cAMP_Responsive_Element_Binding_Protein	cAMP Responsive Element Binding Protein 4|CREB4	Expressed in prostate, brain, pancreas, skeletal muscle, small intestine, testis, leukocytes, and thymus by human CREB4 Gene (bZIP/CREB Family), 395-aa cAMP Responsive Element Binding Protein 4 is a transcription factor with a basic leucine zipper region that binds to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters. CREB4 has 62% identity with mouse Creb3. (NCI)
C38542	CREB5_Gene	CREB_Family_Gene	CREB5 Gene|CRE-BPA|CREB5|CREBPA|cAMP Responsive Element Binding Protein 5 Gene	Human CREB5 Gene (bZIP/CREB Family) encodes alpha, beta, gamma, and delta isoforms of cAMP Responsive Element Binding Protein 5, a transcription factor that binds to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and activates transcription. CREB5 binds to DNA as a homodimer or as a heterodimer with JUN/c-Jun or ATF2/CREBP1. (NCI)
C38543	cAMP_Responsive_Element_Binding_Protein-5	cAMP_Responsive_Element_Binding_Protein	cAMP Responsive Element Binding Protein 5|CREB5|cAMP Response Element-Binding Protein CRE-BPA	Encoded as alpha, beta, gamma, and delta isoforms by human CREB5 Gene (bZIP/CREB Family), cAMP Responsive Element Binding Protein 5 is a transcription factor that binds to octameric DNA palindrome cAMP-response elements (CRE) present in many viral and cellular promoters and activates transcription. CREB5 binds to DNA as a homodimer or as a heterodimer with JUN/c-Jun or ATF2/CREBP1. (NCI)
C38544	EIF2B1_Gene	Translation_Process_Gene	EIF2B1 Gene|EIF2B1|EIF2BA|Eukaryotic Translation Initiation Factor 2B, Subunit 1 Alpha, 26kDa Gene	Human EIF2B1 Gene (EIF2B Alpha/Beta/Delta Family) encodes 305-aa 34-kDa Translation Initiation Factor EIF-2B Alpha Subunit of EIF2B, a heteropentameric complex of alpha, beta, gamma, delta, and epsilon subunits essential for protein synthesis that catalyzes GDP/GTP exchange of its Eukaryotic Initiation Factor 2 substrate. For EIF2 to perform additional rounds of initiation, it must be recycled by GDP/GTP exchange. Rat Eif2b1 protein is 92% identical to human EIF2B1. EIF2B1 defects cause VWM. (NCI)
C38545	Translation_Initiation_Factor-EIF-2B_Alpha_Subunit	Protein_Complex_Subunit	Translation Initiation Factor EIF-2B Alpha Subunit|EIF-2-Beta|EIF-2B|EIF-2B Alpha|EIF-2B GDP-GTP Exchange Factor|EIF2B|EIF2B1|EIF2BA|Eukaryotic Translation Initiation Factor 2B|Eukaryotic Translation Initiation Factor 2B Subunit 1 Alpha 26-kDa	Encoded by human EIF2B1 Gene (EIF2B Alpha/Beta/Delta Family), 305-aa 34-kDa Translation Initiation Factor EIF-2B Alpha Subunit acts in EIF2B, a heteropentameric complex of alpha, beta, gamma, delta, and epsilon subunits essential for protein synthesis that catalyzes GDP/GTP exchange of its Eukaryotic Initiation Factor 2 substrate. For EIF2 to perform additional rounds of initiation, it must be recycled by GDP/GTP exchange. Rat Eif2b1 protein is 92% identical to human EIF2B1. EIF2B1 defects cause VWM. (NCI)
C38546	EIF2B2_Gene	Translation_Process_Gene	EIF2B2 Gene|EIF2B|EIF2B2|EIF2BB|Eukaryotic Translation Initiation Factor 2B, Subunit 2 Beta, 39kDa Gene	Human 8-exon EIF2B2 Gene (EIF2B Alpha/Beta/Delta Family) encodes 351-aa 39-kDa Translation Initiation Factor EIF-2B Beta Subunit of EIF2B, a heteropentameric complex of alpha, beta, gamma, delta, and epsilon subunits essential for protein synthesis that catalyzes GDP/GTP exchange of its Eukaryotic Initiation Factor 2 substrate. For EIF2 to perform additional rounds of initiation, it must be recycled by GDP/GTP exchange. EIF2B2 defects cause VWM and ovarioleukodystrophy. (NCI)
C38547	Translation_Initiation_Factor-EIF-2B_Beta_Subunit	Protein_Complex_Subunit	Translation Initiation Factor EIF-2B Beta Subunit|EIF-2B Beta|EIF-2B GDP-GTP Exchange Factor|EIF2B|EIF2B2|Eukaryotic Translation Initiation Factor 2B Subunit 2 Beta 39-kDa|S20I15|S20III15	Encoded by human EIF2B2 Gene (EIF2B Alpha/Beta/Delta Family), 351-aa 39-kDa Translation Initiation Factor EIF-2B Beta Subunit acts in EIF2B, a heteropentameric complex of alpha, beta, gamma, delta, and epsilon subunits essential for protein synthesis that catalyzes GDP/GTP exchange of its Eukaryotic Initiation Factor 2 substrate. For EIF2 to perform additional rounds of initiation, it must be recycled by GDP/GTP exchange. EIF2B2 defects cause VWM and ovarioleukodystrophy. (NCI)
C38548	EIF2B4_Gene	Translation_Process_Gene	EIF2B4 Gene|EIF2B4|EIF2BD|Eukaryotic Translation Initiation Factor 2B, Subunit 4 Delta, 67kDa Gene	Human EIF2B2 Gene (EIF2B Alpha/Beta/Delta Family) encodes 2 alternative isoforms of 523-aa 58-kDa Translation Initiation Factor EIF-2B Delta Subunit of EIF2B, a heteropentameric complex of alpha, beta, gamma, delta, and epsilon subunits essential for protein synthesis that catalyzes GDP/GTP exchange of its Eukaryotic Initiation Factor 2 substrate. For EIF2 to perform additional rounds of initiation, it must be recycled by GDP/GTP exchange. EIF2B4 defects cause VWM and ovarioleukodystrophy. (NCI)
C38549	Translation_Initiation_Factor-EIF-2B_Delta_Subunit	Protein_Complex_Subunit	Translation Initiation Factor EIF-2B Delta Subunit|EIF-2B|EIF-2B GDP-GTP Exchange Factor|EIF2B|EIF2B Delta|EIF2B4|Eukaryotic Translation Initiation Factor 2B Subunit 4 Delta 67-kDa	Encoded as 2 alternative isoforms by human EIF2B2 Gene (EIF2B Alpha/Beta/Delta Family), 523-aa 58-kDa Translation Initiation Factor EIF-2B Delta Subunit acts in EIF2B, a heteropentameric complex of alpha, beta, gamma, delta, and epsilon subunits essential for protein synthesis that catalyzes GDP/GTP exchange of its Eukaryotic Initiation Factor 2 substrate. For EIF2 to perform additional rounds of initiation, it must be recycled by GDP/GTP exchange. EIF2B4 defects cause VWM and ovarioleukodystrophy. (NCI)
C38550	EIF2B5_Gene	Translation_Process_Gene	EIF2B5 Gene|CACH|CLE|EIF2B5|EIF2BE|Eukaryotic Translation Initiation Factor 2B, Subunit 5 Epsilon, 82kDa Gene|LVWM	Human 16-exon EIF2B5 Gene (EIF2B Gamma/Epsilon Family) encodes 721-aa 80-kDa Translation Initiation Factor EIF-2B Epsilon Subunit of EIF2B, a heteropentameric complex of alpha, beta, gamma, delta, and epsilon subunits essential for protein synthesis that catalyzes GDP/GTP exchange of its Eukaryotic Initiation Factor 2 substrate. For EIF2 to perform additional rounds of initiation, it must be recycled by GDP/GTP exchange. The N-terminal region of eIF2B-epsilon contains a putative nucleotide-binding domain that may be directly involved in nucleotide exchange. EIF2B5 defects cause VWM, ovarioleukodystrophy, and CLE. (NCI)
C38551	Translation_Initiation_Factor-EIF-2B_Epsilon_Subunit	Protein_Complex_Subunit	Translation Initiation Factor EIF-2B Epsilon Subunit|EIF-2B|EIF-2B GDP-GTP Exchange Factor|EIF2B Epsilon|EIF2B5|Eukaryotic Translation Initiation Factor 2B Subunit 5 Epsilon 82-kDa	Encoded by human EIF2B5 Gene (EIF2B Gamma/Epsilon Family), 721-aa 80-kDa Translation Initiation Factor EIF-2B Epsilon Subunit acts in EIF2B, a heteropentameric complex of alpha, beta, gamma, delta, and epsilon subunits essential for protein synthesis that catalyzes GDP/GTP exchange of its Eukaryotic Initiation Factor 2 substrate. For EIF2 to perform additional rounds of initiation, it must be recycled by GDP/GTP exchange. The N-terminal region of eIF2B-epsilon contains a putative nucleotide-binding domain that may be directly involved in nucleotide exchange. EIF2B5 defects cause VWM, ovarioleukodystrophy, and CLE. (NCI)
C38552	FCGR2A_Gene	Receptor_Gene	FCGR2A Gene|CD32|FCG2|FCGR2A|Fc Fragment of IgG, Low Affinity IIA, Receptor (CD32) Gene|IGFR2	Expressed in monocytes, macrophages, neutrophils, eosinophils, platelets, NK cells, and T- and B-lymphocytes, human FCGR2A Gene encodes 281-aa (mature) IgG Fc Receptor IIA, a type I cell surface membrane protein with 2 extracellular IgC2 domains and a low affinity receptor for aggregated IgG Fc region. FCGR2A binding to IgG initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. An Arg167His polymorphism affects efficiency of IgG2 recognition. (NCI)
C38553	IgG-Fc-Receptor-IIA	Fc-Gamma_Receptor-II	IgG Fc Receptor IIA|CD32|CD32 Antigen|FCG2|FCGR2|FCGR2A|FCGR2A1|Fc-Gamma RIIA|Fc-Gamma-RIIA|FcGR|FcRIIA|IGFR2|Low Affinity IgG Fc Fragment Receptor IIA|Low Affinity Immunoglobulin Gamma Fc Region Receptor IIA	Expressed in monocytes, macrophages, neutrophils, eosinophils, platelets, NK cells, and T- and B-lymphocytes by human FCGR2A Gene, 281-aa (mature) IgG Fc Receptor IIA is a type I cell surface membrane protein with 2 extracellular IgC2 domains and a low affinity receptor for aggregated IgG Fc region. FCGR2A binding to IgG initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. An Arg167His polymorphism affects efficiency of IgG2 recognition. (NCI)
C38554	FCGR2B_Gene	Receptor_Gene	FCGR2B Gene|CD32|FCG2|FCGR2B|Fc Fragment of IgG, Low Affinity IIB, Receptor (CD32) Gene|IGFR2	Expressed in monocytes, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B cells, platelets, and placental endothelial, human FCGR2B Gene encodes 3 alternative isoforms of IgG Fc Receptor IIB, a type I cell surface protein with 2 IgC2 domains and the most broadly distributed low affinity receptor for aggregated IgG Fc region. FCGR2B binding to IgG initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. FCGR2B contains a cytoplasmic ITIM motif involved in down modulation of previous cell activation by BCR, TCR or another Fc receptor; phosphorylated ITIM binds to PTPN6/SHP-1 SH2 domain. Chromosome translocation t(1;22)(q22;q11) leads to FCGR2B hyperexpression in a follicular lymphoma. (NCI)
C38555	IgG-Fc-Receptor-IIB	Fc-Gamma_Receptor-II	IgG Fc Receptor IIB|CD32|CD32 Antigen|FCG2|FCGR2|FCGR2B|Fc-Gamma RIIB|Fc-Gamma-RIIB|FcRIIB|IGFR2|Low Affinity IgG Fc Fragment Receptor IIB|Low Affinity Immunoglobulin Gamma Fc Region Receptor IIB	Expressed as 3 alternative isoforms in monocytes, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B cells, platelets, and placental endothelial by human FCGR2B Gene, IgG Fc Receptor IIB is a type I cell surface protein with 2 IgC2 domains and the most broadly distributed low affinity receptor for aggregated IgG Fc region. FCGR2B binding to IgG initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. FCGR2B contains a cytoplasmic ITIM motif involved in down modulation of previous cell activation by BCR, TCR or another Fc receptor; phosphorylated ITIM binds to PTPN6/SHP-1 SH2 domain. Chromosome translocation t(1;22)(q22;q11) leads to FCGR2B hyperexpression in a follicular lymphoma. (NCI)
C38556	FCGR2C_Gene	Receptor_Gene	FCGR2C Gene|CD32|FCG2|FCGR2C|Fc Fragment of IgG, Low Affinity IIC, Receptor for (CD32) Gene|IGFR2	Expressed in monocytes, macrophages, polymorphonuclear cells, and natural killer cells (Isoform 1), human FCGR2C Gene encodes 4 alternative isoforms of IgG Fc Receptor IIC, a type I cell surface protein with 2 IgC2 domains and a low affinity receptor for aggregated IgG Fc region. FCGR2C binding to IgG initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. FCGR2C contains two cytoplasmic ITAM activator motifs involved in cell activation upon receptor aggregation. Isoform 4 may be soluble. (NCI)
C38557	IgG-Fc-Receptor-IIC	Fc-Gamma_Receptor-II	IgG Fc Receptor IIC|CD32|CD32 Antigen|FCGR2C|Fc-Gamma RIIC|Fc-Gamma-RIIC|FcRIIC|Low Affinity IgG Fc Fragment Receptor IIC|Low Affinity Immunoglobulin Gamma Fc Region Receptor IIC	Expressed as 4 alternative isoforms in monocytes, macrophages, polymorphonuclear cells, and natural killer cells (Isoform 1) by human FCGR2C Gene, IgG Fc Receptor IIC is a type I cell surface protein with 2 IgC2 domains and a low affinity receptor for aggregated IgG Fc region. FCGR2C binding to IgG initiates essential effector and regulatory cellular responses against foreign pathogens and soluble antigens that induce phagocytosis of antigen-antibody complexes, removing them from circulation, and modulate B-cell antibody production. FCGR2C contains two cytoplasmic ITAM activator motifs involved in cell activation upon receptor aggregation. Isoform 4 may be soluble. (NCI)
C38558	FCGR3A_Gene	Receptor_Gene	FCGR3A Gene|CD16A|FCG3|FCGR3|FCGR3A|Fc Fragment of IgG, Low Affinity IIIA, Receptor (CD16A) Gene|IGFR3	Highly similar to FCGR3B Gene and expressed in natural killer cells, macrophages, T cells, immature thymocytes, and trophoblasts, human FCGR3A Gene encodes 254-aa 29-kDa (precursor) glycosylated IgG Fc Receptor IIIA, a putative type I membrane protein containing 2 IgC2 domains and receptor for the Fc region of monomeric or aggregated IgG that mediates antibody-dependent responses, such as phagocytosis and antibody-dependent cellular cytotoxicity. FCGR3B exists in a hetero-oligomeric complex with the Fc epsilon receptor I gamma subunit and/or the CD3 zeta subunit, as a soluble receptor produced by proteolytic cleavage. Amino acid conservation between CD16, other Fc receptors, and related Ig suggest similar structures and modes of association. (NCI)
C38559	IgG-Fc-Receptor-IIIA	Fc-Gamma_Receptor-III	IgG Fc Receptor IIIA|CD16|CD16A|FCG3|FCGR3|FCGR3A|Fc-Gamma RIII|Fc-Gamma RIII-Alpha|Fc-Gamma RIIIA|FcR-10|FcRIII|FcRIIIA|IGFR3|IgG Fc Receptor III-2|Low Affinity IgG Fc Receptor IIIA|Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A	Expressed on natural killer cells, macrophages, T cells, immature thymocytes, and trophoblasts by human FCGR3A Gene, 254-aa 29-kDa (precursor) glycosylated IgG Fc Receptor IIIA is a putative type I membrane protein containing 2 IgC2 domains and a receptor for the Fc region of monomeric or aggregated IgG that mediates antibody-dependent responses, such as phagocytosis and antibody-dependent cellular cytotoxicity. FCGR3B exists in a hetero-oligomeric complex with the Fc epsilon receptor I gamma subunit and/or the CD3 zeta subunit, as a soluble receptor produced by proteolytic cleavage. Amino acid conservation between CD16, other Fc receptors, and related Ig suggest similar structures and modes of association. (NCI)
C38560	FCGR3B_Gene	Receptor_Gene	FCGR3B Gene|CD16|CD16B|FCG3|FCGR3|FCGR3B|Fc Fragment of IgG, Low Affinity IIIB, Receptor (CD16B) Gene|IGFR3	Expressed (as NA-1, NA-2, and SH allelic forms) specifically by neutrophils and stimulated eosinophils, human FCGR3B Gene encodes 233-aa 26-kDa (precursor) monomeric IgG Fc Receptor IIIB, a glycosylated (inhibits IgG3 interaction) low affinity receptor for monomeric or aggregated Fc region of IgG, attached to membrane by a GPI-anchor, and containing 2 IgC2 domains. FCGR3B also exists as a soluble receptor produced by proteolytic cleavage. Unlike FCGR3A, FCGR3B is not capable of mediating antibody-dependent cytotoxicity and phagocytosis; FCGR3B may serve as a trap for immune complexes in the peripheral circulation without activating neutrophils. Amino acid conservation between CD16, other Fc receptors, and related Ig suggest similar structures and modes of association. (NCI)
C38561	IgG-Fc-Receptor-IIIB	Fc-Gamma_Receptor-III	IgG Fc Receptor IIIB|CD16|CD16B|FCG3|FCGR3|FCGR3B|Fc Receptor III-1|Fc-Gamma RIII|Fc-Gamma RIII-Beta|Fc-Gamma RIIIB|FcR-10|FcRIII|FcRIIIB|Low Affinity IgG Fc Receptor IIIB|Low Affinity Immunoglobulin Gamma Fc Region Receptor III-B	Expressed (as NA-1, NA-2, and SH allelic forms) specifically by neutrophils and stimulated eosinophils, human FCGR3B Gene encodes 233-aa 26-kDa (precursor) monomeric IgG Fc Receptor IIIB, a glycosylated (inhibits IgG3 interaction) low affinity receptor for monomeric or aggregated Fc region of IgG, attached to membrane by a GPI-anchor, and containing 2 IgC2 domains. FCGR3B also exists as a soluble receptor produced by proteolytic cleavage. Unlike FCGR3A, FCGR3B is not capable of mediating antibody-dependent cytotoxicity and phagocytosis; FCGR3B may serve as a trap for immune complexes in the peripheral circulation without activating neutrophils. Amino acid conservation between CD16, other Fc receptors, and related Ig suggest similar structures and modes of association. (NCI)
C38562	NOS1_Gene	Oxidoreductase_Gene	NOS1 Gene|NOS|NOS1|Nitric Oxide Synthase 1 (Neuronal) Gene	Human NOS1 Gene (NOS Family) encodes 4 alternative isoforms of calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 1 that bind FAD and FMN cofactors, contain a PDZ/DHR and a flavodoxin-like domain, require BH4 which may stabilize the dimer, and synthesize nitric oxide messenger from L-arginine. Neuronal NO displays neurotransmitter properties. N-truncated Isoform 3 possesses enzymatic activity. C-truncated isoform 4 is produced by frameshift exon insertion. NOS1 may interact with DLG4 and forms a ternary complex with CAPON and RASD1. NOS1 is localized beneath the sarcolemma in fast-twitch skeletal muscle fibers by associating with the dystrophin glycoprotein complex. The N-terminal PDZ domain of the neuronal NOS1 may participate in protein-protein interaction and target nNos to synaptic membranes. PIN inhibition may prevent NOS1 dimerization. (NCI)
C38563	Nitric_Oxide_Synthetase-1	Nitric_Oxide_Synthetase	Nitric Oxide Synthase 1|BNOS|Brain Nitric Oxide Synthase|Constitutive NOS|NC-NOS|NNOS|NOS Type I|NOS1|Neuronal NOS|Neuronal Nitric Oxide Synthase	Encoded as 4 alternative isoforms by human NOS1 Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 1 binds FAD and FMN cofactors, contains a PDZ/DHR and a flavodoxin-like domain, requires BH4 which may stabilize the dimer, and synthesizes nitric oxide messenger from L-arginine. Neuronal NO displays neurotransmitter properties. N-truncated Isoform 3 possesses enzymatic activity. C-truncated isoform 4 is produced by frameshift exon insertion. NOS1 may interact with DLG4 and forms a ternary complex with CAPON and RASD1. NOS1 is localized beneath the sarcolemma in fast-twitch skeletal muscle fibers by associating with the dystrophin glycoprotein complex. The N-terminal PDZ domain of the neuronal NOS1 may participate in protein-protein interaction and target nNos to synaptic membranes. PIN inhibition may prevent NOS1 dimerization. (NCI)
C38564	NOS2A_Gene	Oxidoreductase_Gene	NOS2A Gene|NOS2|NOS2A|Nitric Oxide Synthase 2A (Inducible, Hepatocytes) Gene	Induced by lipopolysaccharide, endotoxins, and cytokines in liver, retina, bone cells, and airway epithelia, human NOS2A Gene (NOS Family) encodes 2 alternative isoforms of calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2A that bind FAD and FMN cofactors, contain a flavodoxin-like domain, require BH4 which may stabilize the dimer, and synthesize reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2A binds SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. Aspirin inhibits NOS2A. (NCI)
C38565	Nitric_Oxide_Synthase-2A	Nitric_Oxide_Synthetase	Nitric Oxide Synthase 2A|HEP-NOS|Hepatocyte Nitric Oxide Synthase|INOS|Inducible Nitric Oxide Synthase|Macrophage Nitric Oxide Synthase|NOS|NOS Type II|NOS2|NOS2A	Induced by lipopolysaccharide, endotoxins, and cytokines and expressed as 2 alternative isoforms in liver, retina, bone cells, and airway epithelia by human NOS2A Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2A binds FAD and FMN cofactors, contains a flavodoxin-like domain, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2A binds SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. Aspirin inhibits NOS2A. (NCI)
C38566	NOS2B_Gene	Oxidoreductase_Gene	NOS2B Gene|NOS2B|Nitric Oxide Synthase 2B Gene	Human NOS2B Gene (NOS Family) encodes calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2B that binds FAD and FMN cofactors, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2B may bind SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. (NCI)
C38567	Nitric_Oxide_Synthase-2B	Nitric_Oxide_Synthetase	Nitric Oxide Synthase 2B|NOS Type IIB|NOS2B|NOSIIB|Nitric Oxide Synthase IIB	Encoded by human NOS2B Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2B binds FAD and FMN cofactors, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2B may bind SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. (NCI)
C38568	NOS2C_Gene	Oxidoreductase_Gene	NOS2C Gene|NOS2C|Nitric Oxide Synthase 2C Gene	Human NOS2C Gene (NOS Family) encodes calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2C that binds FAD and FMN cofactors, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2C may bind SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. (NCI)
C38569	Nitric_Oxide_Synthase-2C	Nitric_Oxide_Synthetase	Nitric Oxide Synthase 2C|NOS Type IIC|NOS2C|NOSIIC|Nitric Oxide Synthase IIC	Encoded by human NOS2C Gene (NOS Family), calcium/calmodulin stimulated homodimeric Nitric Oxide Synthase 2C binds FAD and FMN cofactors, requires BH4 which may stabilize the dimer, and synthesizes reactive free radical nitric oxide messenger (from L-arginine). NO has antimicrobial and antitumoral activities in macrophages. NOS2C may bind SLC9A3R1. IL12 requires NOS2 to stimulate NK cell cytotoxicity and to activate STAT4 tyrosine-phosphorylation by TYK2 in innate immunity. (NCI)
C38570	NOS3_Gene	Oxidoreductase_Gene	NOS3 Gene|NOS3|Nitric Oxide Synthase 3 (Endothelial Cell) Gene	Expressed (4-kb mRNA) in platelets and endothelia, 21-kb 26-exon (constitutive TATA-less, SP1, GATA promoter) human NOS3 Gene (NOS Family) encodes conserved 1202-aa 133-kDa Nitric Oxide Synthase 3, a calcium/calmodulin stimulated homodimer stabilized by BH4 that contains a flavodoxin-like domain, binds FAD and FMN cofactors, and synthesizes NO from L-arginine. Endothelial NO appears to exert EDRF activity that inhibits vascular smooth muscle contraction through a cGMP pathway. NOS3 activity also inhibits platelet aggregation and mediates VEGF-induced angiogenesis. Vascular shear stress activates endothelial PI3K and AKT, which directly phosphorylates (Ser1177) and enhances NOS3 activity and calcium sensitivity. Potentially influencing the control of energy balance, NO also triggers cGMP-dependent mitochondrial biogenesis mediated by induction of the master regulator PPARGC1. (NCI)
C38571	Nitric_Oxide_Synthase-3	Nitric_Oxide_Synthetase	Nitric Oxide Synthase 3|CNOS|Constitutive NOS|ECNOS|ENOS|Endothelial NOS|Endothelial Nitric Oxide Synthase|Endothelial Nitric Oxide Synthase 3|NOS Type III|NOS3|NOSIII	Expressed in platelets and endothelia by human NOS3 Gene (NOS Family), conserved constitutive 1202-aa 133-kDa Nitric Oxide Synthase 3 is a calcium/calmodulin stimulated homodimer stabilized by BH4 that contains a flavodoxin-like domain, binds FAD and FMN cofactors, and synthesizes NO from L-arginine. Endothelial NO appears to exert EDRF activity that inhibits vascular smooth muscle contraction through a cGMP pathway. NOS3 activity also inhibits platelet aggregation and mediates VEGF-induced angiogenesis. Vascular shear stress activates endothelial PI3K and AKT, which directly phosphorylates (Ser1177) and enhances NOS3 activity and calcium sensitivity. Potentially influencing the control of energy balance, NO also triggers cGMP-dependent mitochondrial biogenesis mediated by induction of the master regulator PPARGC1. (NCI)
C38572	Leucine_Rich_Repeat_Containing_Protein-17	Protein_with_Unknown_or_Unclassified_Function	Leucine Rich Repeat Containing Protein 17|37-kDa Leucine-Rich Repeat (LRR) Protein|LRRC17|P37NB	Encoded by human P37NB Gene, the function of 313-aa 37-kDa Leucine Rich Repeat Containing Protein 17 is unknown. (NCI)
C38573	Cooperative_Prostate_Cancer_Tissue_Resource	Tissue_Collection	Cooperative Prostate Cancer Tissue Resource|CPCTR|NCI Cooperative Prostate Cancer Tissue Resource|National Cancer Institute Cooperative Prostate Cancer Tissue Resource	The National Cancer Institute (NCI) Cooperative Prostate Cancer Tissue Resource (CPCTR) is funded by the National Cancer Institute to provide researchers with access to primary prostate cancer tissues with associated clinical and followup data. The CPCTR can provide researchers with formalin-fixed, paraffin-embedded primary prostate cancer specimens,and their associated pathologic and clinical information.  This collection is intended to facilitate large research studies that require both archival tissue and clinical and outcome data. (http://www.prostatetissues.org/)
C38574	Syncytiotrophoblastic_Cell	Trophoblastic_Cell	Syncytiotrophoblastic Cell	A large, multinucleated cell having hyperchromatic nuclei and abundant eosinophilic, sometimes vacuolated cytoplasm, in the outer syncytial layer of the trophoblast.
C38575	Cytotrophoblastic_Cell	Trophoblastic_Cell	Cytotrophoblastic Cell	A polygonal, mononucleate cell resembling the cells of the inner layer of the trophoblast, having prominent nucleoli and clear, eosinophilic or basophilic cytoplasm.
C38576	Translation_Process_Protein	Protein_Organized_by_Function	Translation Process Protein	Translation Process Proteins participate in functions at the ribosome whereby the information in mRNA is used to specify the sequence of amino acids in a nascent polypeptide chain.
C38577	RARG_Gene	Nuclear_Receptor_Gene	RARG Gene|NR1B3|RARC|RARG|Retinoic Acid Receptor, Gamma Gene	Human RARG Gene (NR1 Family) encodes alternative 454-aa 50-kDa RARG1 and 443-aa 49-kDa RARG2 isoforms (differ in N-terminal region) of nuclear Retinoic Acid Receptor Gamma, composed of N-terminal modulating domain, DNA-binding domain, and C-terminal steroid-binding domain. RARG is a retinoic acid-activated transcription enhancer factor that exerts profound morphogenic effects on vertebrate development and controls cell functions by regulating gene expression. RARs (alpha, beta, and gamma) require co-regulators to increase selective binding to DNA response elements in target genes and enhance transcriptional activity. Interspecies conservation of each RAR is much higher than conservation of alpha, beta, and gamma receptors in any species. The 3 forms of retinoic acid receptor may perform specific functions. (NCI)
C38578	Retinoic_Acid_Receptor_Gamma	Retinoic_Acid_Receptor	Retinoic Acid Receptor Gamma|RAR Gamma-1|RAR Gamma-2|RARG|Retinoic Acid Receptor Gamma Polypeptide|Retinoic Acid Receptor Gamma-1|Retinoic Acid Receptor Gamma-2	Encoded by human RARG Gene (NR1 Family) as alternative 454-aa 50-kDa RARG1 and 443-aa 49-kDa RARG2 isoforms (differ in N-terminal region), nuclear Retinoic Acid Receptor Gamma is composed of N-terminal modulating domain, DNA-binding domain, and C-terminal steroid-binding domain. RARG is a retinoic acid-activated transcription enhancer factor that exerts profound morphogenic effects on vertebrate development and controls cell functions by regulating gene expression. RARs (alpha, beta, and gamma) require co-regulators to increase selective binding to DNA response elements in target genes and enhance transcriptional activity. Interspecies conservation of each RAR is much higher than conservation of alpha, beta, and gamma receptors in any species. The 3 forms of retinoic acid receptor may perform specific functions. (NCI)
C38579	EEF1A1_Gene	Translation_Process_Gene	EEF1A1 Gene|EEF1|EEF1A|EEF1A1|EEF1A1L14|EF-Tu|Eukaryotic Translation Elongation Factor 1 Alpha 1 Gene|GRAF-1EF|PTI1	Expressed in brain, placenta, lung, liver, kidney, and pancreas, human EEF1A1 Gene (EF-Tu/EF-1A Family) encodes 462-aa 50-kDa cytoplasmic Elongation Factor 1A1, alpha subunit of elongation factor-1 (EEF1) complex and containing domains that bind guanine nucleotides, 80S ribosomes, and aminoacyl-tRNAs. Involved in enzymatic delivery and GTP-dependent binding of aminoacyl-tRNAs to the A-site of 80S ribosomes during protein biosynthesis, EEF1A1 interacts with the beta subunit of EEF1 to hydrolyze GTP to GDP. (NCI)
C38580	_6q14_1	Chromosome_Band	6q14.1	A chromosome band present on 6q
C38581	Elongation_Factor-1A1	Protein_Complex_Subunit	Elongation Factor 1A1|CTCL Tumor Antigen|EEF1A1|EF-1-Alpha-1|EF-Tu|EF1A-Like Protein|Elongation Factor 1 Alpha Subunit|Elongation Factor 1-Alpha|Elongation Factor 1-Alpha 1|Elongation Factor Tu|Eukaryotic Translation Elongation Factor 1 Alpha 1|Eukaryotic Translation Elongation Factor 1 Alpha 1-Like 14|Glucocorticoid Receptor AF-1 Specific Elongation Factor|Prostate Tumor-Inducing Protein 1|Translation Elongation Factor 1 Alpha 1-Like 14|eEF1A-1	Expressed in brain, placenta, lung, liver, kidney, and pancreas by human EEF1A1 Gene (EF-Tu/EF-1A Family), 462-aa 50-kDa cytoplasmic Elongation Factor 1A1 is the alpha subunit of elongation factor-1 (EEF1) complex and contains domains that bind guanine nucleotides, 80S ribosomes, and aminoacyl-tRNAs. Involved in enzymatic delivery and GTP-dependent binding of aminoacyl-tRNAs to the A-site of 80S ribosomes during protein biosynthesis, EEF1A1 interacts with the beta subunit of EEF1 to hydrolyze GTP to GDP. (NCI)
C38582	EEF1A2_Gene	Translation_Process_Gene	EEF1A2 Gene|EEF1A2|EEF1AL|EF1A|Eukaryotic Translation Elongation Factor 1 Alpha 2 Gene|HS1|STN	Expressed in terminally differentiated brain, heart, and skeletal muscle cells, single-copy 12-kb 8-exon human EEF1A2 Gene (EF-Tu/EF-1A Family) encodes 463-aa 50-kDa Elongation Factor 1A2, the alpha subunit of elongation factor-1 (EEF1) complex responsible for enzymatic delivery and GTP-dependent binding of aminoacyl tRNAs to the A-site of ribosomes during protein biosynthesis. EEF1A gene coding regions are highly similar; EEF1A2 exhibits 92% amino acid identity to EEF1A1. The TATA-less EEF1A2 promotor contains a CpG island, E boxes, EGR-type binding sites, a GATA motif, and a MEF2-binding site. EEF1A2 has oncogenic properties: it enhances focus formation, allows anchorage-independent growth, and decreases fibroblast doubling time. EEF1A2 may be critical in development of ovarian cancer. (NCI)
C38583	Elongation_Factor-1A2	Protein_Complex_Subunit	Elongation Factor 1A2|EEF1A2|EF-1-Alpha-2|Elongation Factor 1-Alpha 2|Elongation Factor-1 Alpha|Eukaryotic Translation Elongation Factor 1 Alpha 2|Statin S1|eEF1A-2	Expressed in terminally differentiated brain, heart, and skeletal muscle cells by human EEF1A2 Gene (EF-Tu/EF-1A Family), 463-aa 50-kDa Elongation Factor 1A2 is an alpha subunit of elongation factor-1 (EEF1) complex responsible for enzymatic delivery and GTP-dependent binding of aminoacyl tRNAs to the A-site of ribosomes during protein biosynthesis. EEF1A gene coding regions are highly similar; EEF1A2 exhibits 92% amino acid identity to EEF1A1. EEF1A2 has oncogenic properties: it enhances focus formation, allows anchorage-independent growth, and decreases fibroblast doubling time. EEF1A2 may be critical in development of ovarian cancer. (NCI)
C38584	EEF2_Gene	Translation_Process_Gene	EEF2 Gene|EEF2|EF2|Eukaryotic Translation Elongation Factor 2 Gene	Human EEF2 Gene (EF-G/EF-2 Family) encodes highly conserved 857-aa 95-kDa cytoplasmic Elongation Factor 2, essential for protein synthesis and required for GTP-dependent ribosomal A-site to P-site translocation of nascent protein chains: peptidyl-tRNA is moved from the ribosome acceptor site to the next mRNA codon by hydrolysis of GTP bound to EF2. EF2 is completely inactivated by EF-2 kinase phosphorylation. Diphtheria and PA toxins inhibit protein synthesis by catalyzing covalent ADP-ribosylation of EF2 (from NAD). (NCI)
C38585	_19pter-q12	Chromosome_Band	19pter-q12	A chromosome band present on 19p
C38586	Elongation_Factor-2	Translation_Process_Protein	Elongation Factor 2|EEF2|EF2|Eukaryotic Translation Elongation Factor 2|Polypeptidyl-tRNA Translocase	Encoded by human EEF2 Gene (EF-G/EF-2 Family), highly conserved 857-aa 95-kDa cytoplasmic Elongation Factor 2 is essential for protein synthesis and required for GTP-dependent ribosomal A-site to P-site translocation of nascent protein chains: peptidyl-tRNA is moved from the ribosome acceptor site to the next mRNA codon by hydrolysis of GTP bound to EF2. EF2 is completely inactivated by EF-2 kinase phosphorylation. Diphtheria and PA toxins inhibit protein synthesis by catalyzing covalent ADP-ribosylation of EF2 (from NAD). (NCI)
C38587	Anti-MART-1_TCR_Retroviral_Vector-Transduced_Autologous_PBL	Biological_Agent	Anti-MART-1 TCR Retroviral Vector-Transduced Autologous PBL	Human peripheral blood lymphocytes (PBL) isolated from a patient with melanoma and genetically modified ex vivo to react with the melanoma antigen MART. These genetically modified PBL are stimulated with MART and then transferred back to the patient to migrate to and kill MART-expressing melanoma cells. (NCI04)
C38588	PLA2G4A_Gene	Esterase_Gene	PLA2G4A Gene|CPLA2|PLA2G4|PLA2G4A|Phospholipase A2, Group IVA (Cytosolic, Calcium-Dependent) Gene	Expressed in macrophages, platelets, neutrophils, fibroblasts, and lung endothelia, human PLA2G4A Gene encodes Cytosolic Phospholipase A2G4A, activated by serine phosphorylation and translocated to the membrane in a calcium-dependent fashion. The N-terminal lipid membrane-associated C2 domain regulates PLA2G4A by presenting the active site to substrates in response to cytosolic Ca(2+) elevation. PLA2G4A interacts with HTATIP and is stimulated by ATP, EGF, thrombin, and bradykinin. PLA2G4A selectively hydrolyzes ubiquitous membrane (sn-2) arachidonyl phospholipids releasing the 20-carbon arachidonic acid precursor for many eicosanoid effectors involved in hemodynamic regulation, inflammatory responses, and other cellular processes. Eicosanoid lipids include prostaglandins, thromboxanes, leukotrienes, hydroxy- and epoxy-fatty acids, lipoxins, and isoprostanes. (NCI)
C38589	Cytosolic_Phospholipase-A2G4A	Cytosolic_Phospholipase-A2	Cytosolic Phospholipase A2G4A|CPLA2|Calcium-Dependent Cytosolic Phospholipase A2 IVA|Cytosolic Phospholipase A2|Lysophospholipase|PLA2G4|PLA2G4A|Phosphatidylcholine 2-Acylhydrolase|Phospholipase A2|Phospholipase A2 Group IVA|Phospholipase A2 IVA|cPLA2-Alpha	Expressed in macrophages, platelets, neutrophils, fibroblasts, and lung endothelia by human PLA2G4A Gene, Cytosolic Phospholipase A2G4A is activated by serine phosphorylation and translocated to the membrane in a calcium-dependent fashion. The N-terminal lipid membrane-associated C2 domain regulates PLA2G4A by presenting the active site to substrates in response to cytosolic Ca(2+) elevation. PLA2G4A interacts with HTATIP and is stimulated by ATP, EGF, thrombin, and bradykinin. PLA2G4A selectively hydrolyzes ubiquitous membrane (sn-2) arachidonyl phospholipids releasing the 20-carbon arachidonic acid precursor for many eicosanoid effectors involved in hemodynamic regulation, inflammatory responses, and other cellular processes. Eicosanoid lipids include prostaglandins, thromboxanes, leukotrienes, hydroxy- and epoxy-fatty acids, lipoxins, and isoprostanes. (NCI)
C38590	_15q11_2-q21_3	Chromosome_Band	15q11.2-q21.3	A chromosome band present on 15q
C38591	PLA2G4B_Gene	Esterase_Gene	PLA2G4B Gene|PLA2G4B|Phospholipase A2, Group IVB (Cytosolic) Gene	Widely expressed (8.5-kb mRNA; brain, pancreas strongest), 5-exon human PLA2G4B Gene encodes 913-aa 100-kD calcium-dependent Cytosolic Phospholipase A2G4B, containing a calcium- and lipid-binding C2 domain. PLA2G4B shares approximately 30% sequence identity with PLA2G4A and PLA2G4C, including conservation of 4 catalytically essential residues, and initiates production of inflammatory mediators by hydrolyzing membrane phospholipid sn-2 bonds, releasing arachidonic acid. (NCI)
C38592	Cytosolic_Phospholipase-A2G4B	Cytosolic_Phospholipase-A2	Cytosolic Phospholipase A2G4B|Calcium-Dependent Cytosolic Phospholipase A2 IVB|Cytosolic Phospholipase A2IVB|HsT16992|PLA2G4B|Phospholipase A2 Group IVB|Phospholipase A2 IVB|cPLA2-Beta	Widely expressed (brain, pancreas strongest) by human PLA2G4B Gene, 913-aa 100-kD calcium-dependent Cytosolic Phospholipase A2G4B contains a calcium- and lipid-binding C2 domain and shares approximately 30% sequence identity with PLA2G4A and PLA2G4C, including conservation of 4 catalytically essential residues. PLA2G4B initiates production of inflammatory mediators by hydrolyzing membrane phospholipid sn-2 bonds, releasing arachidonic acid. (NCI)
C38593	PLA2G4C_Gene	Esterase_Gene	PLA2G4C Gene|PLA2G4C|Phospholipase A2, Group IVC (Cytosolic, Calcium-Independent) Gene	Expressed (3-kb mRNA) in skeletal muscle, heart, and other tissues, human PLA2G4C Gene encodes 541-aa Cytosolic Phospholipase A2G4C, a calcium-independent membrane-associated prenylated phospholipase with 28% amino acid sequence identity to cPLA2-Alpha that catalyzes (cleaving at sn-1 or sn-2 sites) release of arachidonate from phospholipids. (NCI)
C38594	Cytosolic_Phospholipase-A2G4C	Cytosolic_Phospholipase-A2	Cytosolic Phospholipase A2G4C|Calcium-Independent Cytosolic Phospholipase A2 Group IVC|Calcium-Independent Cytosolic Phospholipase A2 IVC|Cytosolic Phospholipase A2 Gamma|Cytosolic Phospholipase A2 IVC|PLA2G4C|Phospholipase A2 Group IVC|Phospholipase A2IVC|cPLA2-Gamma	Expressed (3-kb mRNA) in skeletal muscle, heart, and other tissues by human PLA2G4C Gene, 541-aa Cytosolic Phospholipase A2G4C is a calcium-independent membrane-associated prenylated phospholipase with 28% amino acid sequence identity to cPLA2-Alpha that catalyzes (cleaving at sn-1 or sn-2 sites) release of arachidonate from phospholipids. (NCI)
C38595	PLA2G4D_Gene	Esterase_Gene	PLA2G4D Gene|PLA2G4D|Phospholipase A2, Group IVD (Cytosolic) Gene	Human PLA2G4D Gene encodes Cytosolic Phospholipase A2G4D. Phospholipases catalyze release of fatty acids from phospholipids. (NCI)
C38596	Cytosolic_Phospholipase-A2G4D	Cytosolic_Phospholipase-A2	Cytosolic Phospholipase A2G4D|Cytosolic Phospholipase A2 Delta|Cytosolic Phospholipase A2 IVD|PLA2G4D|Phospholipase A2 Group IVD|Phospholipase A2 IVD|cPLA2-Delta	Human Cytosolic Phospholipase A2G4D is encoded by PLA2G4D Gene. Phospholipases catalyze release of fatty acids from phospholipids. (NCI)
C38597	PLA2G6_Gene	Esterase_Gene	PLA2G6 Gene|IPLA2|PLA2G6|Phospholipase A2, Group VI (Cytosolic, Calcium-Independent) Gene	Human PLA2G6 Gene encodes 4 alternative isoforms of conserved calcium-independent 806-aa 85-kD Cytosolic Phospholipase A2G6 expressed in distinct tissue distributions. Ankyrin-iPLA2-1 and -2 isoforms (encoding only ankyrin repeats) lack the catalytic domain and appear to exert negative regulation on PLA2G6. Cytoplasmic isoform SH-iPLA2 contains 7 ANK repeats. Isoform LH-iPLA2 is membrane bound. Implicated in normal phospholipid remodeling, in NO- or vasopressin-induced arachidonic acid release, and in leukotriene and prostaglandin production, PLA2G6 catalyzes release of fatty acids from phospholipids; PLA2G6 may selectively hydrolyze sn-2 over sn-1 fatty acids. PLA2G6 may participate in FAS-mediated apoptosis and in regulating transmembrane ion flux in B-cells. (NCI)
C38598	Cytosolic_Phospholipase-A2G6	Cytosolic_Phospholipase-A2	Cytosolic Phospholipase A2G6|85kDa Calcium-Independent Phospholipase A2|CaI-PLA2|Calcium-Independent Cytosolic Phospholipase A2|Calcium-Independent Cytosolic Phospholipase A2 Group VI|Calcium-Independent Cytosolic Phospholipase A2VI|Calcium-Independent Phospholipase A2|GVI PLA2|Group VI Phospholipase A2|PLA2G6|Phospholipase A2 Group VI|Phospholipase A2VI|iPLA2	Encoded as 4 alternative isoforms in distinct tissue distributions by human PLA2G6 Gene, conserved calcium-independent 806-aa 85-kD Cytosolic Phospholipase A2G6 appears to catalyze release of fatty acids from phospholipids in normal phospholipid remodeling, in NO- or vasopressin-induced arachidonic acid release, and in leukotriene and prostaglandin production; PLA2G6 may selectively hydrolyze sn-2 over sn-1 fatty acids. Cytoplasmic isoform SH-iPLA2 contains 7 ANK repeats. Isoform LH-iPLA2 is membrane bound. Ankyrin-iPLA2-1 and -2 isoforms (encoding only ankyrin repeats) lack the catalytic domain and appear to exert negative regulation on PLA2G6. PLA2G6 may participate in FAS-mediated apoptosis and in regulating transmembrane ion flux in B-cells. (NCI)
C38599	FNTA_Gene	Protein_Complex_Subunit_Gene	FNTA Gene|FNTA|FPTA|Farnesyltransferase, CAAX Box, Alpha Gene|PGGT1A	Human FNTA Gene (Protein Prenyltransferase Alpha Subunit Family) encodes 379-aa 44-kDa CAAX Box Farnesyltransferase Alpha Subunit of 100-kD heterodimeric Farnesyl Protein Transferase or GGTase-I (different beta chain), which catalyze 15-C farnesyl or 20-C geranylgeranyl thioether linkage to the C-terminal Cys in C(ys)AAX boxes of many proteins as a means of membrane localization. FTase and GGTase beta chains are catalytic for specific substrates. With both conserved alpha and beta subunits essential for catalytic activity, FNTA (5 PFTA repeats) may promote a stable complex with substrate; beta binds the substrate. Interacting with TGF-beta and Activin Type I receptors, FNTA is likely a key component of p21ras signaling, a farnesyltransferase substrate; membrane localization and activity of RAS is dependent on farnesylation. (NCI)
C38600	_8p22-q11	Chromosome_Band	8p22-q11	A chromosome band present on 8p
C38601	CAAX-Farnesyltransferase_Alpha-Subunit	Protein_Complex_Subunit	CAAX Box Farnesyltransferase Alpha Subunit|CAAX Box Farnesyltransferase Alpha|FNTA|FPTA|FTase-Alpha|GGTase-I-Alpha|PGGT1A|Protein Farnesyltransferase Type I Alpha Subunit|Protein Farnesyltransferase/Geranylgeranyltransferase Type I Alpha Subunit|RAS Proteins Prenyltransferase Alpha|Type I Protein Geranyl-Geranyltransferase Alpha Subunit	Encoded by human FNTA Gene (Protein Prenyltransferase Alpha Subunit Family), 379-aa 44-kDa CAAX Box Farnesyltransferase Alpha Subunit is part of 100-kD heterodimeric Farnesyl Protein Transferase or GGTase-I (different beta chain), which catalyze 15-C farnesyl or 20-C geranylgeranyl thioether linkage to the C-terminal Cys in C(ys)AAX boxes of many proteins as a means of membrane localization. FTase and GGTase beta chains are catalytic for specific substrates. With both conserved alpha and beta subunits essential for catalytic activity, FNTA (5 PFTA repeats) may promote a stable complex with substrate; beta binds the substrate. Interacting with TGF-beta and Activin Type I receptors, FNTA is likely a key component of p21ras signaling, a farnesyltransferase substrate; membrane localization and activity of RAS is dependent on farnesylation. (NCI)
C38602	_14q23-q24	Chromosome_Band	14q23-q24	A chromosome band present on 14q
C38603	FNTB_Gene	Protein_Complex_Subunit_Gene	FNTB Gene|FNTB|FPTB|Farnesyltransferase, CAAX Box, Beta Gene	Human FNTB Gene (Protein Prenyltransferase Alpha Subunit Family) encodes 437-aa 49-kDa CAAX Box Farnesyltransferase Beta Subunit of 100-kD heterodimeric Farnesyl Protein Transferase, which catalyzes 15-C farnesyl thioether linkage to the C-terminal Cys in C(ys)AAX boxes of many proteins as a means of membrane localization. The FTase beta chain is catalytic for specific substrates. With both conserved alpha and beta subunits essential for catalytic activity, FNTB (5 PFTB repeats) binds the substrate; the alpha subunit may promote a stable complex with substrate. (NCI)
C38604	CAAX-Farnesyltransferase_Beta_Subunit	Protein_Complex_Subunit	CAAX Box Farnesyltransferase Beta Subunit|CAAX Box Farnesyltransferase Beta|FNTB|FPTB|FTase-Beta|Protein Farnesyltransferase Beta Subunit|RAS Proteins Prenyltransferase Beta	Encoded by human FNTB Gene (Protein Prenyltransferase Alpha Subunit Family), 437-aa 49-kDa CAAX Box Farnesyltransferase Beta Subunit is part of 100-kD heterodimeric Farnesyl Protein Transferase, which catalyzes 15-C farnesyl thioether linkage to the C-terminal Cys in C(ys)AAX boxes of many proteins as a means of membrane localization. The FTase beta chain is catalytic for specific substrates. With both conserved alpha and beta subunits essential for catalytic activity, FNTB (5 PFTB repeats) binds the substrate; the alpha subunit may promote a stable complex with substrate. (NCI)
C38605	GCLM_Gene	Protein_Complex_Subunit_Gene	GCLM Gene|GCLM|GLCLR|Glutamate-Cysteine Ligase, Modifier Subunit Gene	Widely expressed (skeletal muscle highest), human GCLM Gene (Aldo/Keto Reductase Family) encodes 274-aa 31-kDa Gamma-Glutamylcysteine Synthetase Regulatory Protein, the light subunit of heterodimeric Gamma-Glutamylcysteine Synthetase, first rate limiting enzyme of the glutathione biosynthesis pathway. (NCI)
C38606	Gamma-Glutamylcysteine_Synthetase_Regulatory_Protein	Protein_Complex_Subunit	Gamma-Glutamylcysteine Synthetase Regulatory Protein|GCLM|GLCLR|GSC Light Chain|Gamma-ECS|Gamma-Glutamylcysteine Synthetase|Gamma-Glutamylcysteine Synthetase 30.8kD Protein|Glutamate-Cysteine Ligase|Glutamate-Cysteine Ligase Modifier Subunit|Glutamate-Cysteine Ligase Regulatory Protein|Glutamate-Cysteine Ligase Regulatory Subunit	Widely expressed (skeletal muscle highest) by human GCLM Gene (Aldo/Keto Reductase Family), 274-aa 31-kDa Gamma-Glutamylcysteine Synthetase Regulatory Protein is the light subunit of heterodimeric Gamma-Glutamylcysteine Synthetase, first rate limiting enzyme of the glutathione biosynthesis pathway. (NCI)
C38607	GCLC_Gene	Protein_Complex_Subunit_Gene	GCLC Gene|GCLC|GCS|GLCL|GLCLC|Glutamate-Cysteine Ligase, Catalytic Subunit Gene	Human GCLC Gene (Glutamate-Cysteine Ligase 3 Family) encodes 636-aa 73-kDa Gamma-Glutamylcysteine Synthetase Catalytic Subunit, the heavy subunit of heterodimeric Gamma-Glutamylcysteine Synthetase, first rate limiting enzyme of the glutathione biosynthesis pathway. GCLC defects cause hemolytic anemia. (NCI)
C38608	Gamma-Glutamylcysteine_Synthetase_Catalytic_Subunit	Protein_Complex_Subunit	Gamma-Glutamylcysteine Synthetase Catalytic Subunit|GCLC|GCS|GCS Heavy Chain|GLCL|GLCLC|Gamma-ECS|Gamma-Glutamylcysteine Synthetase|Glutamate-Cysteine Ligase Catalytic Subunit	Encoded by human GCLC Gene (Glutamate-Cysteine Ligase 3 Family), 636-aa 73-kDa Gamma-Glutamylcysteine Synthetase Catalytic Subunit is the heavy subunit of heterodimeric Gamma-Glutamylcysteine Synthetase, first rate limiting enzyme of the glutathione biosynthesis pathway. GCLC defects cause hemolytic anemia. (NCI)
C38609	ADORA1_Gene	G_Protein-Coupled_Receptor_Gene	ADORA1 Gene|ADORA1|Adenosine A1 Receptor Gene	Widely expressed (ubiquitous in CNS), 6-exon human ADORA1 Gene (GPCR1 Family) encodes conserved 326-aa 37-kDa Adenosine A1 Receptor, a cell-surface integral membrane protein containing 7 transmembrane domains that interacts with a heterotrimeric G protein complex in response to adenosine ligand to suppress cAMP accumulation through adenylate cyclase inhibition and regulate diverse physiologic functions including cardiac rate and contractility, smooth muscle tone, sedation, release of neurotransmitters, platelet function, lipolysis, renal function, white blood cell function, and spermatozoal capacitation. ADORA1 appears to colocalize with adenosine deaminase, which may be necessary for high affinity agonist binding. A potent biologic mediator, most effects of adenosine protect cells during stress. (NCI)
C38610	Adenosine-A1_Receptor	Adenosine_Receptor	Adenosine A1 Receptor|ADORA1	Widely expressed (ubiquitous in CNS) by human ADORA1 Gene (GPCR1 Family), conserved 326-aa 37-kDa Adenosine A1 Receptor is a cell-surface integral membrane protein containing 7 transmembrane domains that interacts with a heterotrimeric G protein complex in response to adenosine ligand to suppress cAMP accumulation through adenylate cyclase inhibition and regulate diverse physiologic functions including cardiac rate and contractility, smooth muscle tone, sedation, release of neurotransmitters, platelet function, lipolysis, renal function, white blood cell function, and spermatozoal capacitation. ADORA1 appears to colocalize with adenosine deaminase, which may be necessary for high affinity agonist binding. A potent biologic mediator, most effects of adenosine protect cells during stress. (NCI)
C38611	ADORA2A_Gene	G_Protein-Coupled_Receptor_Gene	ADORA2A Gene|ADORA2|ADORA2A|Adenosine A2A Receptor Gene|RDC8|hA2aR	Expressed in basal ganglia, vasculature, and platelets, human ADORA2A Gene (GPCR1 Family) encodes 412-aa 45-kDa Adenosine A2A Receptor, a cell-surface integral membrane protein containing 7 transmembrane domains that interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate cAMP accumulation through adenylate cyclase activation, is a major target of caffeine, and modulates the activity of various neuronal populations, platelets, neutrophils, and mast cells, and smooth muscle cells in bronchi and vasculature. A potent biologic mediator, most effects of adenosine protect cells during stress. (NCI)
C38612	Adenosine-A2A_Receptor	Adenosine_Receptor	Adenosine A2A Receptor|ADORA2|ADORA2A|Adenosine A2 Receptor|Adenosine Receptor Subtype A2A|RDC8|hA2aR	Expressed in basal ganglia, vasculature, and platelets by human ADORA2A Gene (GPCR1 Family), 412-aa 45-kDa Adenosine A2A Receptor is a cell-surface integral membrane protein containing 7 transmembrane domains that interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate cAMP accumulation through adenylate cyclase activation, is a major target of caffeine, and modulates the activity of various neuronal populations, platelets, neutrophils, and mast cells, and smooth muscle cells in bronchi and vasculature. A potent biologic mediator, most effects of adenosine protect cells during stress. (NCI)
C38613	ADORA2B_Gene	G_Protein-Coupled_Receptor_Gene	ADORA2B Gene|ADORA2|ADORA2B|Adenosine A2B Receptor Gene	Human ADORA2B Gene (GPCR1 Family) encodes 332-aa 360-kDa Adenosine A2B Receptor, a cell-surface integral membrane protein containing 7 transmembrane domains that interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate cAMP accumulation through adenylate cyclase activation. ADORA2B is also a Netrin-1 receptor in axon elongation, inducing cAMP accumulation. Netrin-1 also binds DCC, which interacts with ADORA2B as well; Netrin-1 growth-promotion may require a DCC/A2B receptor complex or act through DCC independently of ADORA2B. Cycling expression of clock gene Period-1 (rodent) depends on adenosine A2B receptor, which occurs through nocturnal activation of melatonin Mt1 receptors. (NCI)
C38614	Adenosine-A2B_Receptor	Adenosine_Receptor	Adenosine A2B Receptor|ADORA2|ADORA2B	Encoded by human ADORA2B Gene (GPCR1 Family), 332-aa 360-kDa Adenosine A2B Receptor is a cell-surface integral membrane protein containing 7 transmembrane domains that interacts with a heterotrimeric G protein complex in response to adenosine ligand to stimulate cAMP accumulation through adenylate cyclase activation. ADORA2B is also a Netrin-1 receptor in axon elongation, inducing cAMP accumulation. Netrin-1 also binds DCC, which interacts with ADORA2B as well; Netrin-1 growth-promotion may require a DCC/A2B receptor complex or act through DCC independently of ADORA2B. Cycling expression of clock gene Period-1 (rodent) depends on adenosine A2B receptor, which occurs through nocturnal activation of melatonin Mt1 receptors. (NCI)
C38615	ADORA3_Gene	G_Protein-Coupled_Receptor_Gene	ADORA3 Gene|A3AR|ADORA3|Adenosine A3 Receptor Gene	Widely expressed (2-kb mRNA) and having a TATA-less promotor with CCAAT box, SP1, CEBPB, and GATA sites, 2-exon human ADORA3 Gene (GPCR1 Family) encodes 318-aa 36-kDa Adenosine A3 Receptor, a cell-surface integral membrane protein containing 7 transmembrane domains and 3 potential N-glycosylation sites that interacts with a heterotrimeric G protein complex in response to adenosine ligand to suppress cAMP accumulation through adenylate cyclase inhibition. ADORA3 exhibits about 71% homology with A3ar (rat). Released during ischemia, adenosine exerts a potent protective effect through ADORA3 on cardiac ventricular cells. ADORA3 may have a role in reproduction. (NCI)
C38616	Adenosine-A3_Receptor	Adenosine_Receptor	Adenosine A3 Receptor|A3AR|ADORA3	Widely expressed by human ADORA3 Gene (GPCR1 Family), 318-aa 36-kDa Adenosine A3 Receptor is a cell-surface integral membrane protein containing 7 transmembrane domains and 3 potential N-glycosylation sites that interacts with a heterotrimeric G protein complex in response to adenosine ligand to suppress cAMP accumulation through adenylate cyclase inhibition. ADORA3 exhibits about 71% homology with A3ar (rat). Released during ischemia, adenosine exerts a potent protective effect through ADORA3 on cardiac ventricular cells. ADORA3 may have a role in reproduction. (NCI)
C38617	Head_and_Neck_Part	Body_Part	Head and Neck Part
C38618	PRIM2A_Gene	Protein_Complex_Subunit_Gene	PRIM2A Gene|PRIM2|PRIM2A|Primase, Polypeptide 2A, 58kDa Gene	Human PRIM2A Gene (Eukaryotic Primase Large Subunit Family) encodes 509-aa 58-kDa Primase Polypeptide 2A, the large subunit of heterodimeric DNA Primase. Eukaryotic DNA replication involves a chromosomal replication apparatus containing key enzymatic components DNA Primase and DNA Polymerase Alpha. DNA Primase is a polymerase that synthesizes small RNA primers for Okazaki fragments made during discontinuous DNA replication. (NCI)
C38619	Primase_Polypeptide-2A	Protein_Complex_Subunit	Primase Polypeptide 2A|DNA Primase 58kDa Subunit|DNA Primase Large Subunit|DNA Primase Large Subunit 58kDa|DNA Primase Subunit p58|p58	Encoded by human PRIM2A Gene (Eukaryotic Primase Large Subunit Family), 509-aa 58-kDa Primase Polypeptide 2A is the large subunit of heterodimeric DNA Primase. Eukaryotic DNA replication involves a chromosomal replication apparatus containing key enzymatic components DNA Primase and DNA Polymerase Alpha. DNA Primase is a polymerase that synthesizes small RNA primers for Okazaki fragments made during discontinuous DNA replication. (NCI)
C38620	Integumentary_System_Part	Body_Part	Integumentary System Part
C38621	Diaphragm_Part	Musculoskeletal_System_Part	Diaphragm Part
C38622	Epithelium_Part	Tissue_Part	Epithelium Part
C38624	Extracellular_Matrix_Part	Retired_Concepts	Extracellular Matrix Part
C38625	Tissue_Part	Body_Part	Normal Tissue Part
C38626	Organ_of_Special_Sense_Part	Body_Part	Organ of Special Sense Part
C38627	Membrane_Part	Tissue_Part	Membrane Part
C38628	Upper_Extremity_Part	Extremity_Part	Upper Extremity Part
C38629	Lower_Extremity_Part	Extremity_Part	Lower Extremity Part
C38630	Extremity_Part	Body_Part	Extremity Part
C38631	Opening_of_the_Thorax	Body_Part	Opening of the Thorax
C38632	Tonsil_Part	Immune_System_Part	Tonsil Part
C38633	Electro-osmosis_Route_of_Drug_Administration	Drug_Route_of_Administration	Electro-osmosis Route of Administration|EL-OSMOS|ELECTRO-OSMOSIS|Electro-Osmosis	Administration of drug by way of diffusion, through a membrane in an electric field. Electro-osmosis describes the active transport of non-ionized solutes associated with the bulk flow of fluid in the direction of the counter-ions that occurs with iontophoretic transport of other, ionized solutes. Using this method, even a neutral compound can be administered. Method can be used for local and systemic drug delivery.
C38634	Doppler_Echocardiography	Echocardiography	Doppler Echocardiography|Doppler Study
C38635	inv_22q12	Chromosomal_Inversion	inv(22q12)
C38636	t_11_17_q13q11	Chromosomal_Translocation	t(11;17)(q13;q11)
C38637	t_12_21_p13_q22_TEL-AML1	Chromosomal_Translocation	t(12;21)(p13;q22)	t(12;21) is a chromosomal translocation, involved in TEL-AML1 oncogene formation, that produces a chimeric gene encoding a protein consisting of the N-terminal HLH domain of the TEL ETS-like transcription factor fused with a nearly complete AML1 protein. t(12;21) is the most frequent translocation causing ALL, accounting for 20% of ALL cases.
C38638	t_1_14_q21-22q32	Chromosomal_Translocation	t(1;14)(q21-22;q32)
C38639	Delta_Cell_of_the_Pancreas	Delta_Cell|Islet_Cell	Delta Cell of the Pancreas|Pancreatic Somatostatin Cell|Pancreatic Somatostatin Secreting Cell|Somatostatin Cell of the Pancreas|Somatostatin Secreting Cell of the Pancreas	A type of cell in the pancreatic islets that secretes somatostatin.
C38640	Neoplastic_B-Lymphocyte	Neoplastic_Lymphocyte	Neoplastic B-Lymphocyte
C38641	Neoplastic_T-Lymphocyte	Neoplastic_T-Lymphocyte_and_Neoplastic_Natural_Killer_Cell	Neoplastic T-Lymphocyte
C38642	Lymphoblasts_25_Percent_or_Less_of_Bone_Marrow_Nucleated_Cells	Atypical_Lymphocytes_Present_in_Bone_Marrow|Blast_Cells_Increased_in_Bone_Marrow	Lymphoblasts 25 Percent or Less of Bone Marrow Nucleated Cells
C38643	Extensive_Bone_Marrow_and_Blood_Involvement	Bone_Marrow_and_Blood_Involvement	Extensive Bone Marrow and Blood Involvement
C38644	Bone_Pain	Pain	Bone Pain
C38645	Tartrate_Resistant_Acid_Phosphatase_Positivity	Abnormal_Hematology_Test_Result	Tartrate Resistant Acid Phosphatase Positive Cells Present|TRAP Positivite Cells Present
C38646	Fried-Egg_Appearance_of_the_Bone_Marrow	Morphologic_Finding	Fried-Egg Appearance of the Bone Marrow
C38647	Prolymphocytes_Exceed_55_Percent_of_Lymphoid_Cells_in_the_Peripheral_Blood	Atypical_Lymphocytes_Present_in_Peripheral_Blood	Prolymphocytes Exceed 55 Percent of Lymphoid Cells in the Peripheral Blood
C38648	Negative_Bone_Marrow_and_Peripheral_Blood	Negative_Test_Result	Negative Bone Marrow and Peripheral Blood
C38649	Vacuolated_Plasma_Cells_in_the_Bone_Marrow	Abnormal_Cells_Present	Vacuolated Plasma Cells in the Bone Marrow
C38650	Defective_Mu_Heavy_Chain_Present	Defective_Heavy_Chain_Present	Defective Mu Heavy Chain Present
C38653	Nuclear_Pleomorphism_Present	Retired_Concepts	Nuclear Pleomorphism Present
C38654	Bone_Marrow_and_Blood_Involvement	Hematopoietic_System_Finding	Bone Marrow and Blood Involvement
C38655	Bulky_Disease	Clinical_Course_of_Disease	Bulky Disease
C38656	ALK_Kinase_Upregulation	Protein_Deregulation	ALK Kinase Overexpression|ALK Kinase Upregulation|Anaplastic Lymphoma Kinase Overexpression
C38657	Neoplastic_Immunoblast-Like_B-Lymphocyte	Neoplastic_Large_B-Lymphocyte	Neoplastic Immunoblast-Like B-Lymphocyte
C38658	Transformed_Peripheral_B-Lymphocyte	Peripheral_B-Lymphocyte	Transformed Peripheral B-Lymphocyte	A mature lymphocyte that has entered the peripheral blood system and has been activated into one of several mature B-cell subtypes.
C38660	Neoplastic_Large_B-Lymphocyte_with_Pale_Cytoplasm	Neoplastic_Large_B-Lymphocyte	Neoplastic Large B-Lymphocyte with Pale Cytoplasm
C38661	Composite_Lymphoma	Lymphoma	Composite Lymphoma	Coexistence of Hodgkin's and non-Hodgkin's lymphoma in the same anatomic site.  A representative example is classical Hodgkin's lymphoma and chronic lymphocytic leukemia co-occurring in the same lymph node. --2004
C38662	Pericardial_Cavity	Cavity	Pericardial Cavity
C38664	Postmeiotic_Segregation_Increased-2-Like-1	Retired_Concepts	PostmeioticSegregation Increased-2-Like 1|PMS3|Postmeiotic Segregation Increased 2-Like Protein 1
C38665	Chest_Pain	Pain	Chest Pain
C38666	Monomorphic_Cellular_Infiltrate	Cellular_Infiltrate	Monomorphic Cellular Infiltrate
C38667	Polymorphic_Cellular_Infiltrate	Cellular_Infiltrate	Polymorphic Cellular Infiltrate
C38668	Intrahepatic_Portion_of_the_Left_Hepatic_Duct	Intrahepatic_Bile_Duct	Intrahepatic Portion of the Left Hepatic Duct
C38669	Intrahepatic_Portion_of_the_Right_Hepatic_Duct	Intrahepatic_Bile_Duct	Intrahepatic Portion of the Right Hepatic Duct
C38670	Hilar_Portion_of_the_Left_Hepatic_Duct	Hilar_Portion_of_the_Hepatic_Duct	Hilar Portion of the Left Hepatic Duct
C38671	Hilar_Portion_of_the_Right_Hepatic_Duct	Hilar_Portion_of_the_Hepatic_Duct	Hilar Portion of the Right Hepatic Duct
C38672	Transforming_Growth_Factor-Beta_Induced_Protein-IGH3	Protein_with_Unknown_or_Unclassified_Function	Transforming Growth Factor-Beta Induced Protein IGH3|Beta IGH3|Keratoepithelin|RGD-CAP|RGD-Containing Collagen Associated Protein|Transforming Growth Factor Beta-Induced 68kDa Protein	Constitutively expressed by human TGFBI Gene in many tissues (high in corneal epithelium) and TGF-beta induced, highly conserved 683-aa 75-kDa (precursor) extracellular Transforming Growth Factor-Beta Induced Protein IGH3 contains an N-signal peptide, four 140-aa FAS1 domains with internal homology, and a C-RGD motif. RGD is found in many extracellular matrix proteins that modulate cell adhesion and serves as a ligand recognition sequence for several integrins. With similar structure to fasciclin I (putative neuronal cell adhesion protein) and OSF-2 (potential bone adhesion protein), TGFBI binds to types I, II, and IV collagens. A potential adhesion protein, TGFBI may play role in cell-collagen interactions, may be associated with microfibrils and the cell surface, and may be involved in endochondral bone formation. TGFBI defects cause CDGG1, CDRB, CDL1, CDL3A, and ACD. (NCI)
C38673	T-Cell_Large_Granular_Lymphocyte	Large_Granular_Lymphocyte|Mature_T-Lymphocyte	T-Cell Large Granular Lymphocyte|T-LGL	A thymus-dependent white blood cell that has been activated by contact with antigen and has enlarged by macromolecular synthesis with presence of large granules visible by light microscopy.
C38674	Widespread_Disease	Clinical_Course_of_Disease	Widespread Disease|Extensive Disease|Generalized Disease
C38675	Cutaneous_Route_of_Drug_Administration	Topical_Route_of_Drug_Administration	Cutaneous Route of Administration|CUTAN|CUTANEOUS|Cutaneous	Administration to the skin.
C38676	Percutaneous_Route_of_Drug_Administration	Topical_Route_of_Drug_Administration	Percutaneous Route of Administration|PERCUT|PERCUTANEOUS|Percutaneous	Administration of a drug by the way of absorption through the skin, usually for systemic action. The route allows sustained therapeutic plasma drug levels and avoids first pass effect. Simplicity of administration tends to result in high patient compliance.
C38677	Peridural_Route_of_Drug_Administration	Parenteral_Route_of_Drug_Administration	Peridural Route of Administration|P-DURAL|PERIDURAL|Peridural	Administration to the outside of the dura mater of the spinal cord.
C38678	Yttrium_Y_90_Monoclonal_Antibody_Hu3S193	Radioimmunoconjugate	Yttrium Y 90 Monoclonal Antibody Hu3S193|Y90 MOAB Hu3S193	A radioimmunotherapeutic agent consisting of a humanized murine monoclonal antibody (hu3S193) directed against the tumor-associated Lewis Y epithelial antigen chelated to the radioisotope yttrium-90.  Yttrium Y 90 monoclonal antibody Hu3S193 binds to Lewis Y epithelial antigen-expressing tumor cells, selectively delivering a cytotoxic dose of beta radiation. (NCI04)
C38679	Yttrium_Y_90_Glass_Microspheres	Therapeutic_Implant	Yttrium Y 90 Glass Microspheres|TheraSphere	An injectable formulation of yttrium Y 90 consisting of glass microspheres containing the radioisotope yttrium Y 90.  When injected into the tumor vascular bed, yttrium Y 90 glass microspheres occlude tumor blood vessels and deliver a cytotoxic dose of beta radiation to the tumor site, thereby reducing the tumor burden. (NCI04)
C38680	Valeriana_Officinalis	Vascular_Plant	Valeriana officinalis|Valerian	A plant, the root of which is used to derive an herbal medicinal preparation with antianxiety and hypnotic activities.  Valerian root contains volatile oils (sesquiterpenes and monoterpenes), valepotriates, alkaloids and lignans.  This agent may inhibit the uptake and stimulate the release of [3H]GABA (gamma-aminobutyric acid), resulting in decreased central nervous system activity. (NCI04)
C38681	Vaccinia-PSA-TRICOM_Vaccine	Vaccinia_Vaccine	Vaccinia-PSA-TRICOM Vaccine|Vaccinia-Prostate-Specific Antigen-TRICOM Vaccine	A vaccine formulation consisting of recombinant vaccinia virus encoding prostate specific antigen (PSA) and recombinant vaccinia virus encoding three co-stimulatory molecule transgenes B7.1, ICAM-1, and LFA-3 (TRICOM). Vaccination with PSA in combination with TRICOM may enhance antigen presentation, resulting in the augmentation of a cytotoxic T cell (CTL) immune response against tumor cells expressing PSA.
C38682	Recombinant_Tyrosinase-Related_Protein-2	Tumor_Antigen	Recombinant Tyrosinase-Related Protein-3|TRP-2|Tyrosinase-Related Protein-2	A recombinant therapeutic agent which is chemically identical to or similar to an endogenous non-mutated melanocyte differentiation antigen expressed by both normal and malignant melanocytes. Vaccinations with recombinant tyrosinase-related protein-2 may elicit an antitumoral cytotoxic T-cell response against tumor cells and some normal cells that express tyrosinase-related protein-2. (NCI04)
C38683	Traumeel_S	Chemoprotective_Agent	Traumeel S|TRS	Diluted extracts isolated from plants and minerals, including belladonna, arnica, St. Johns wort, and Echinacea.  As a homeopathic mouth rinse preparation, Traumeel S exhibits antiinflammatory activity; the mechanism of action has not been fully elucidated.  This agent may reduce the severity and duration of treatment-related stomatitis. (NCI04)
C38684	TAC-101	Retinoic_Acid_Agent	TAC-101|TAC 101	A retinobenzoic acid with potential antineoplastic activity.  TAC-101 inhibits retinoblastoma-gene product (RB) phosphorylation and increases the presence of 2 cyclin-dependent kinase (CDK) inhibitors, resulting in cell cycle arrest.  This agent also causes a cytotoxic decline in cyclin A and thymidylate synthase expression. (NCI04)
C38685	Siplizumab	Monoclonal_Antibody	Siplizumab|MEDI-507	A monoclonal immunoglobulin G1 antibody with potential antineoplastic activity. Siplizumab binds to CD2, a specific receptor found in T cells and NK cells, thereby triggering a host immune response that results in lysis of CD2+ cells, selective suppression of the immune system, and control of activated T cell growth.
C38686	Ruthenium_106	Radioisotope	Ruthenium 106|Ru-106|Ruthenium Ru 106	A radioactive isotope of the rare element ruthenium, a member of the light platinum group. A radioactive plaque containing ruthenium 106 may be inserted into the eye to irradiate ophthalmic tumors. (NCI04)
C38687	Methoxypolyethylene_Glycol_Epoetin_beta	Epoetin_Beta	Methoxypolyethylene Glycol Epoetin beta|Ro 50-3821	A pegylated form of recombinant human erythropoietin, a glycosylated protein naturally produced in the kidney that stimulates erythrocyte production in the bone marrow. Methoxypolyethylene glycol epoetin beta may reverse anemias induced by cancer therapy. (NCI04)
C38688	Ravuconazole	Antifungal_Agent	Ravuconazole|BMS-207147	A triazole with antifungal activity. Ravuconazole inhibits 14a demethylase, an enzyme involved in sterol synthesis, resulting in lysis of the fungal cell wall and fungal cell death. (NCI04)
C38689	Polyphenon_E	Green_Tea_Extract	Polyphenon E|Polyphenon E Topical Ointment	A defined, decaffeinated green tea polyphenol mixture isolated from the plant Camellia sinensis with antiviral and antioxidant activities.  Polyphenon E may possess chemopreventive properties. (NCI04)
C38690	PI-88	Angiogenesis_Activator_Inhibitor	PI-88	A sulfated oligosaccharide. PI-88 inhibits heparanase activity and heparan sulfate binding to fibroblast growth factor (FGF) and vascular endothelial growth factor (VEGF), resulting in decreased tumor proliferation, inhibition of angiogenesis, and inhibition of metastasis. (NCI04)
C38691	Phentolamine	Alpha-adrenergic_Blocking_Agent	Phentolamine Mesylate|2-[N-p'-Tolyl-N-(m'-hydroxyphenyl)aminomethyl]imidazoline|PHENTOLAMINE MESYLATE|Phentolamine|Regitine	A synthetic imidazoline with alpha-adrenergic antagonist activity. As a competitive alpha-adrenergic antagonist, phentolamine binds to alpha-1 and alpha-2 receptors, resulting in a decrease in peripheral vascular resistance and vasodilatation. This agent also may block 5-hydroxytryptamine (5-HT) receptors and stimulate release of histamine from mast cells. (NCI04)
C38692	Pertuzumab	Monoclonal_Antibody_2C4	Pertuzumab|Omnitarg|rhuMAb2C4	A humanized recombinant monoclonal antibody directed against the extracellular dimerization domain of the HER-2 tyrosine kinase receptor. Binding of the antibody to the dimerization domain of the HER-2 tyrosine kinase receptor protein directly inhibits the ability of the HER-2 tyrosine kinase receptor protein (the most common pairing partner) to dimerize with other HER tyrosine kinase receptor proteins; inhibiting receptor protein dimerization prevents the activation of HER signaling pathways, resulting in tumor cell apoptosis. (NCI04)
C38693	Paricalcitol	Vitamin_D	Paricalcitol|PARICALCITOL	A synthetic noncalcemic, nonphosphatemic vitamin D analogue.  Paricalcitol binds to the vitamin D receptor and has been shown to reduce parathyroid hormone (PTH) levels. This agent also increases the expression of PTEN ('Phosphatase and Tensin homolog deleted on chromosome Ten'), a tumor-suppressor gene, in leukemic cells and cyclin-dependent kinase inhibitors, resulting in tumor cell apoptosis and tumor cell differentiation into normal phenotypes. (NCI04)
C38694	OSI-7904L	Thymidylate_Synthase_Inhibitor	OSI-7904L|GS7904L	A liposome-encapsulated formulation of the benzoquinazoline folate analog OSI-7904 with antineoplastic activity. As a thymidylate synthase inhibitor, OSI-7904 noncompetitively binds to thymidylate synthase, resulting in inhibition of thymine nucleotide synthesis and DNA replication. Liposome encapsulation improves the efficacy and increases the half-life of OSI-7904. (NCI04)
C38695	Multi-epitope_Melanoma_Peptide_Vaccine	Melanoma_Vaccine	Multi-epitope Melanoma Peptide Vaccine|MULTI-EP MP VAC	A peptide cancer vaccine consisting of a combination of peptides derived form several melanoma epitopes. Vaccination with multi-epitope melanoma peptide vaccine stimulates the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing the corresponding antigens, resulting in tumor cell lysis.  This vaccine may stimulate a broader CTL response compared to single-antigen vaccines. (NCI04)
C38696	Moxifloxacin	Quinolone_Antibiotic	Moxifloxacin Hydrochloride|Avelox|BAY 128039|MOXIFLOXACIN HYDROCHLORIDE|Moxifloxacin|Viagmox	A fluoroquinolone antibacterial antibiotic. Moxifloxacin binds to and inhibits the bacterial enzymes DNA gyrase (topoisomerase II) and topoisomerase IV, resulting in inhibition of DNA replication and repair and cell death in sensitive bacterial species. (NCI04)
C38697	Monoclonal_Antibody_HuHMFG1	Monoclonal_Antibody	Monoclonal Antibody HuHMFG1|HuHMFG1	A humanized monoclonal antibody directed against MUC1, a mucin glycoprotein overexpressed in breast and other carcinomas.  Monoclonal antibody HuHMFG1 stimulates antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells expressing MUC1, resulting in a decrease in tumor burden. (NCI04)
C38698	Hyperviscosity	Abnormal_Laboratory_Test	Hyperviscosity
C38700	Melanoma_Helper_Peptide_Vaccine	Melanoma_Vaccine	Melanoma Helper Peptide Vaccine|MHP VAC	A multivalent vaccine consisting of peptides derived from melanoma-associated antigens and an adjuvant peptide derived from tetanus toxoid. Vaccination with this agent may stimulate a host cytotoxic T-cell response against tumor cells expressing melanoma-associated antigens, resulting in tumor cell lysis. (NCI04)
C38701	Lutetium_Lu_177_Monoclonal_Antibody_J591	Radioimmunoconjugate	Lutetium Lu 177 Monoclonal Antibody J591|Lu 177 MOAB J591	A radioimmunoconjugate consisting of a humanized monoclonal antibody directed against the extracellular domain of prostate-specific membrane antigen linked to a beta-emitting radioisotope (lutetium-177).  This radioimmunoconjugate binds to tumor cells that express the extracellular domain of prostate-specific membrane antigen, delivering beta particle radiation selectively to tumor cells expressing this antigen and so limiting the exposure of normal tissues to ionizing radiation.
C38702	Neoplastic_Small_B-Lymphocyte	Neoplastic_B-Lymphocyte|Neoplastic_Small_Lymphocyte	Neoplastic Small B-Lymphocyte
C38703	Lamotrigine	Anticonvulsant_Agent	Lamotrigine|LAMOTRIGINE|Lamictal	A synthetic phenyltriazine with antiepileptic and analgesic properties.  Lamotrigine enhances the action of gamma-aminobutyric acid, an inhibitory neurotransmitter, which may result in a reduction of pain-related transmission of signals along nerve fibers. This agent may also inhibit voltage-gated sodium channels, suppress glutamate release, and inhibit serotonin reuptake. (NCI04)
C38705	Absorbable_Gelatin_Sponge	Sponge	Absorbable Gelatin Sponge|Gelatin Sponge, Absorbable|Gelfoam	A sterile hemostatic agent composed of purified porcine-derived gelatin.  In regional chemotherapy, absorbable gelatin sponge may be used to embolize arteries in the region of a tumor in order to block or retard blood flow; this blockage results in a locally increased concentration of chemotherapeutic agents delivered to the tumor when chemotherapeutic agents are infused into the embolized arterial circulation upstream of the blockage.
C38706	Garlic	Nutritional_Supplement	Garlic|Ajo|Allium Sativum|Allium sativum	A bulbous herb isolated from the plant Allium sativum with potential antineoplastic activity. Garlic contains a number of different organosulfur compounds, some of which have displayed antineoplastic activity. (NCI04)
C38707	Fruit_and_Vegetable_Extracts	Nutritional_Supplement	Fruit and Vegetable Extracts|Juice Plus	Extracts from fruits and vegetables that contain fiber, vitamins, minerals, and other natural substances with antioxidant, lipid-lowering, and antiproliferative properties. Used in chemoprevention therapy, these extracts may prevent the development or recurrence of cancer. (NCI04)
C38708	Fowlpox-PSA-TRICOM_Vaccine	Fowlpox_Virus_Vaccine	Fowlpox-PSA-TRICOM Vaccine|fPSA-TRI	A cancer vaccine consisting of a recombinant fowlpox virus encoding human prostate-specific antigen (PSA) and TRICOM, a combination of three immunostimulants (i.e., B7.1, ICAM-1, and LFA-3). Administration of this agent may induce a cytotoxic T cell response against PSA-expressing tumor cells.  Dendritic cells infected with TRICOM vectors greatly enhance naive T-cell activation and peptide-specific T-cell stimulation. Fowlpox adenovirus is an attractive vector because its genome is easy to manipulate and it is replication incompetent in mammalian cells. (NCI04)
C38709	Deslorelin	Gonadotropin-Releasing_Hormone_Analog	Deslorelin|6-D-Tryptophan-9-(N-ethyl-L-prolinamide)-1-9-luteinizing Hormone-releasing Factor (Swine)|Deslorelin Acetate|GnRH Agonist	A synthetic nonapeptide analogue of the natural gonadotrophin releasing hormone (GnRH) with potential antineoplastic activity. Deslorelin binds to and activates pituitary gonadotropin releasing hormone (GnRH) receptors. Continuous, prolonged administration of goserelin in males results in pituitary GnRH receptor desensitization and inhibition of pituitary secretion of follicle stimulating hormone (FSH) and luteinizing hormone (LH), leading to a significant decline in testosterone production; in females, prolonged administration results in a decrease in estradiol production. (NCI04)
C38710	Defective_Gamma_Heavy_Chain_Present	Defective_Heavy_Chain_Present	Defective Gamma Heavy Chain Present
C38711	CC-8490	Selective_Estrogen_Receptor_Modulator	CC-8490|SPC8490	A benzopyran with potential antineoplastic activity.  CC-8490 acts as a selective estrogen receptor modulator (SERM), inhibiting the proliferation of estrogen-sensitive breast cancer cells.  This agent also inhibits growth and induces apoptosis of glioblastoma cells via a mechanism independent of estrogen receptor-related mechanisms. (NCI04)
C38712	Carbon-11_Acetate	Radioconjugate	Carbon-11 Acetate	The acetate salt of the radioisotope carbon-11. Although the mechanism is unclear, carbon-11 acetate preferentially accumulates in tumor tissue, serving as a tracer for imaging tumors with positron emission tomography (PET). (NCI04)
C38713	BMS-354825	Tyrosine_Kinase_Inhibitor	BMS-354825	An orally bioavailable synthetic small molecule-inhibitor of SRC-family protein-tyrosine kinases.  BMS-354825 binds to and inhibits the growth-promoting activities of these kinases. Apparently because of its less stringent binding affinity for the BCR-ABL kinase, BMS-354825 has been shown to overcome the resistance to imatinib of chronic myeloid leukemia (CML) cells harboring BCR-ABL kinase domain point mutations. SRC-family protein-tyrosine kinases interact with variety of cell-surface receptors and participate in intracellular signal transduction pathways; tumorigenic forms can occur through altered regulation or expression of the endogenous protein and by way of virally-encoded kinase genes. (NCI04)
C38714	BB-10901	Immunoconjugate	BB-10901|huN901-DM1	An immunoconjugate of a humanized murine monoclonal antibody (huN-901) and DMI, a semi-synthetic derivative of the plant-derived ansa macrolide maytansine. The antibody moiety of BB-10901 selectively attaches to CD56 antigen, a neural cell adhesion molecule (NCAM)) expressed on the surface of cells of small cell lung cancer (SCLC) and other neuroendocrine (NE) tumors. Thus, the DMI conjugate is targeted specifically to CD56-expressing tumor cells, where it inhibits tubulin polymerization and assembly, resulting in inhibition of mitosis and cell cycle arrest in the S phase. (NCI04)
C38715	Autologous-Immunoglobulin-Idiotype-KLH-Conjugate-Vaccine	Antineoplastic_Vaccine	Autologous-Immunoglobulin-Idiotype-KLH-Conjugate-Vaccine|Autologous Immunoglobulin Idiotype-Keyhole Limpet Hemocyanin Conjugate Vaccine	A cancer vaccine composed of tumor-specific idiotype determinants derived from an individual's tumor cells which are conjugated to keyhole limpet hemocyanin, an immunostimulant carrier protein. When injected into the individual from whom the tumor cells were isolated, this vaccine may stimulate an antitumoral cytotoxic T-lymphocytic immune response. (NCI04)
C38716	Anidulafungin	Antifungal_Agent	Anidulafungin|LY303366	A cyclic lipopeptide echinocandin derivative with antifungal activity.  Anidulafungin inhibits 1,3 beta-D-glucan synthase, an enzyme involved in fungal cell wall synthesis, resulting in cell lysis and death. This agent is active against Candida species and Aspergillus. (NCI04)
C38717	Anakinra	Interleukin-1_Receptor_Antagonist	Anakinra|Kineret	A recombinant human nonglycosylated interleukin-1 (IL-1) receptor antagonist with potential antineoplastic activity. Anakinra binds to the IL-1 receptor, thereby blocking the binding of the IL-1 to and activation of its receptor. Blockade of IL-1 activity may inhibit the cascade of downstream pro-angiogenic factors such as vascular endothelial cell growth factor, tumor necrosis factor-alpha, and IL-6, resulting in inhibition of tumor angiogenesis. (NCI04)
C38718	AG-013736	Tyrosine_Kinase_Inhibitor	AG-013736	An orally bioavailable tyrosine kinase inhibitor. AG-013736 inhibits the proangiogenic cytokines vascular endothelial growth factor (VEGF) and platelet-derived growth factor receptor (PDGF), thereby exerting an anti-angiogenic effect.  (NCI04)
C38719	_3-AP_Fludarabine	Chemotherapy_Regimen	3-AP/Fludarabine|3AP/FAMP	A combination of the thiosemicarbazone 3-aminopyridine-2-carboxaldehyde (3-AP) and the nucleoside analogue fludarabine with antineoplastic activity. The agents in 3-AP/fludarabine, act synergistically to inhibit the enzyme ribonucleotide reductase.. Composed of two subunits, this enzyme catalyzes the rate-limiting step in the conversion of ribonucleotides to deoxyribonucleotides. The 3-AP binds to and inactivates one subunit while fludarabine binds to and inactivates the other.  Fludarabine also inhibits DNA polymerase alpha and DNA primase. At low concentrations, this agent arrests tumor cells in the S-phase of the cell cycle; at higher concentrations, in the G0/G1 phase of the cell cycle. (NCI04)
C38720	Transgenic_Lymphocyte_Immunization_Vaccine	Antineoplastic_Vaccine	Transgenic Lymphocyte Immunization Vaccine|TLI Vaccine	A vaccine consisting of a preparation of allogeneic lymphocytes that encode a gene for telomerase.  In transgenic lymphocyte immunization, the transgenic cells are infused into the patient, where they serve as antigen- presenting cells (APCs) with the dual function of antigen synthesis and presentation.  Vaccination produces an immune response targeting cancer cells expressing telomerase. (NCI04)
C38721	Nuclear_Pleomorphism	Morphologic_Finding	Nuclear Pleomorphism|Nuclear Pleomorphism Present
C38722	High-Dose_Chemotherapy_with_Stem_Cell_Support	High_Dose_Chemotherapy	High-Dose Chemotherapy with Stem Cell Support|HDC/ASCT|High-Dose Chemotherapy with Autologous Stem Cell Transplant
C38723	Humanized_Monoclonal_Antibody_LM609	Monoclonal_Antibody	Humanized Monoclonal Antibody LM609|Monoclonal Antibody Anti-alpha V beta 3 Integrin	A humanized monoclonal IgG1 antibody directed against the vitronectin receptor alpha v beta 3 integrin.  Humanized monoclonal antibody LM609 blocks the binding of ligands, such as vitronectin, to alpha v beta 3 integrin, resulting in inhibition of angiogenesis and metastasis. Alpha v beta 3 integrin is a cell adhesion and signaling receptor that is expressed on the surface of tumor vessel endothelial cells, some tumor cells, and a number of other cell types. (NCI04)
C38724	Recombinant_MAGE-3-1_Antigen	Vaccine_Antigen	Recombinant MAGE-3.1 Antigen|MAGE-3|MAGE-3.1	A recombinant tumor-specific melanoma antigen. Vaccination with recombinant MAGE-3.1 antigen may induce a host immune response against MAGE-expressing cells, resulting in antitumoral T cell-mediated cytotoxicity. MAGE-expressing cells are found in melanoma, non-small-cell lung carcinoma (NSCLC), head and neck squamous cell carcinoma, transitional cell carcinoma of the bladder, and esophageal carcinoma. (NCI04)
C38725	Valeriana_Officinalis_Extract	Sedative_and_Hypnotic	Valeriana Officinalis Extract|Valerian	An extract isolated from the root of the plant Valeriana officinalis.  Valeriana officinalis extract inhibits the metabolic enzyme gamma-aminobutyric acid (GABA) transaminase and stimulates the synaptic release of GABA, an inhibitory neurotransmitter, resulting in sedation. (NCI04)
C38726	Human_Papillomavirus_16_E6_Peptide	Vaccine_Antigen	Synthetic Human Papillomavirus 16 E6 Peptide|HPV-16 E6|Human Papillomavirus 16 E6 Peptide	A synthetic peptide sequence of human papillomavirus (HPV) type 16 oncoprotein E6.  The E6 oncoprotein is implicated in the tumorigenesis of cervical carcinoma.  Vaccination with HPV 16 E6 peptide may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against cells expressing the E6 oncoprotein, resulting in tumor cell lysis.
C38727	Villous_Lymphocyte	Neoplastic_B-Lymphocyte	Villous Lymphocyte
C38728	Proteolytic_Enzymes	Miscellaneous_Biologic_Response_Modifier	Proteolytic Enzymes|Enzymes, Proteolytic	Enzymes produced and secreted by the pancreas which aid in the proteolysis of proteins in the digestive tract. Pancreatic proteolytic enzymes include trypsin, chymotrypsin and carboxypeptidase; these enzymes are secreted as zymogens, inactive precursors of the enzymes, and are activated in the lumen of the digestive canal. Another proteolytic enzyme, enteropeptidase, is associated with the brush border of enterocytes; this enzyme catalyses the conversion of trypsinogen into trypsin which, in turn, can activate a number of other pancreatic zymogens. (NCI04)
C38729	Marginal_Zone_B-Lymphocyte	Mature_B-Lymphocyte	Marginal Zone B-Lymphocyte	A lymphocyte found in the marginal zones of lymphoid tissues. It has a naive B lymphoid lineage and plays an important role in the early phases of immune response with its ability to rapidly differentiate into an antibody secreting cell. These cells can directly activate T cells, interact with other antigen presenting cells, transporting and concentrating antigen during the course of T-dependent and T-independent immune responses.
C38730	Lymphoepithelial_Lesion_Present	Morphologic_Finding	Lymphoepithelial Lesion
C38731	Villous_Atrophy	Morphologic_Finding	Villous Atrophy
C38732	Defective_Alpha_Heavy_Chain_Present	Defective_Heavy_Chain_Present	Defective Alpha Heavy Chain Present
C38733	Mouse_Hepatic_System_Neoplasm	Mouse_Digestive_System_Neoplasms|Mouse_Liver_Disorder	Mouse Hepatic System Neoplasm
C38737	Mouse_Bile_Duct_Hyperplasia	Non-Neoplastic_Proliferation_of_the_Mouse_Liver	Mouse Bile Duct Hyperplasia
C38739	Mouse_Cholangiocarcinoma	Malignant_Neoplasms_of_Mouse_Liver	Mouse Cholangiocarcinoma|Bile Duct Carcinoma of Mouse	Cuboidal to columnar epithelium with prominent rounded nuclei.
C38740	Mouse_Cholangioma	Benign_Neoplasms_of_Mouse_Liver	Mouse Cholangioma|Bile Duct Adenoma of Mouse	Collection of multiple empty acini lined by a single layer of cuboidal or flattened epithelium. Papillary projections may be present.
C38743	Mouse_Hepatocellular_Hyperplasia	Non-Neoplastic_Proliferation_of_the_Mouse_Liver	Mouse Hepatocellular Hyperplasia
C38744	Mouse_Oval_Cell_Hyperplasia	Non-Neoplastic_Proliferation_of_the_Mouse_Liver	Mouse Oval Cell Hyperplasia
C38745	Mouse_Pre-Neoplastic_Hepatocellular_Foci	Non-Neoplastic_Proliferation_of_the_Mouse_Liver	Mouse Pre-Neoplastic Hepatocellular Foci|Mouse Hyperplastic Focus
C38748	Mouse_Hepatocholangiocellular_Adenoma	Benign_Neoplasms_of_Mouse_Liver	Mouse Hepatocholangiocellular Adenoma	combination of hepatocytes and bile duct epithelium lesions
C38749	Mouse_Hepatocholangiocellular_Adenocarcinoma	Malignant_Neoplasms_of_Mouse_Liver	Mouse Hepatocholangiocellular Adenocarcinoma|Mouse Hepatocholangiocellular Carcinoma	combination of hepatocytes and bile duct epithelium lesions
C38751	Mouse_Ito_Cell_Tumor	Benign_Neoplasms_of_Mouse_Liver	Mouse Ito Cell Tumor, Benign|Lipoma of Mouse
C38752	Non-Neoplastic_Proliferation_of_the_Mouse_Liver	Mouse_Cancer-Related_Conditions|Mouse_Liver_Disorder	Non-Neoplastic Proliferation of the Mouse Liver
C38754	Mouse_Liver_Disorder	Mouse_Digestive_System_Disorder	Mouse Liver Disorder
C38755	Hepatocellular_Adenoma_of_the_Mouse	Benign_Neoplasms_of_Mouse_Liver	Hepatocellular Adenoma of the Mouse	Distortion of normal architecture, hepatocellular plates; compression of adjacent tissue, cellular atypism. May be subclassified as to cell staining characteristics: basophilic, eosinophilic, amphophilic or mixed
C38756	Hepatocellular_Carcinoma_of_the_Mouse	Malignant_Neoplasms_of_Mouse_Liver	Hepatocellular Carcinoma of the Mouse	Cellular atypism, invasion into adjacent tissue, large nucleus with prominent nucleoli, mitotic figures are numerous and may be bizarre.
C38757	Negative_Finding	Disease_Laboratory_Finding_Modifier	Negative Finding	A finding of normality following an examination or investigation looking for the presence of a microorganism, disease, or condition. (NCI)
C38758	Positive_Finding	General_Modifier	Positive Finding	An observation confirming the presence of a disease, condition, or microorganism. (NCI)
C38759	Epstein-Barr_Virus_Infection	Viral_Infection	Epstein-Barr Virus Infection|EBV Infection
C38760	Submucosal_Invasive_Colon_Adenocarcinoma	Colon_Adenocarcinoma	Submucosal Invasive Colon Adenocarcinoma
C38761	HPV_16E7_86-93_Lipopeptide_Vaccine	Antineoplastic_Vaccine	HPV 16E7 86-93 Lipopeptide Vaccine|E7(86-93) Lipopeptide|HPV-16E7 (86-93)	A peptide vaccine consisting of amino acids 86 through 93 of the viral oncoprotein human papillomavirus (HPV) 16 E7.  HPV-16E7 is tumorigenic and strongly associated with cervical cancer.  Vaccination with HPV-16E7 (86-93) may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells positive for HPV-16 E7, resulting in decreased tumor growth. HPV-16 infection may be tumorigenic and is highly associated with cervical cancer. (NCI04)
C38762	Mucoepidermoid_Thyroid_Carcinoma	Mucoepidermoid_Carcinoma|Thyroid_Carcinoma	Thyroid Gland Mucoepidermoid Carcinoma|Mucoepidermoid Thyroid Carcinoma|Mucoepidermoid Thyroid Gland Carcinoma	A primary, low grade carcinoma of the thyroid gland composed of groups of squamoid and mucous cells, surrounded by fibrous tissue.  Prominent cystic structures may be present.  The clinical course is usually indolent. (NCI05)
C38763	Sclerosing_Mucoepidermoid_Thyroid_Carcinoma_with_Eosinophilia	Mucoepidermoid_Thyroid_Carcinoma	Thyroid Gland Sclerosing Mucoepidermoid Carcinoma with Eosinophilia|Sclerosing Mucoepidermoid Thyroid Carcinoma with Eosinophilia|Sclerosing Mucoepidermoid Thyroid Gland Carcinoma with Eosinophilia	A rare type of mucoepidermoid carcinoma of the thyroid gland, usually associated with chronic lymphocytic thyroiditis.  It exhibits a unique morphologic appearance consisting of a squamoid, nested growth pattern, dense fibrosis, and mucinous differentiation.  The histogenesis of this unusual carcinoma has been debated, and it is unclear if it arises from remnants of the ultimobranchial body or from the follicular epithelial cells.  -- 2004
C38764	Scaffolding_Protein	Structural_Protein	Scaffolding Protein	Scaffolding Proteins participate in many cellular functions by serving as a supportive base that spatially or temporally organizes, juxtaposes, regulates, and/or promotes the function of other cellular elements (usually proteins). (NCI)
C38765	Squamoid_Differentiation	Tissue_Differentiation	Squamoid Differentiation
C38766	Lymphocytic_Thyroiditis	Thyroiditis	Lymphocytic Thyroiditis
C38767	Chronic_Lymphocytic_Thyroiditis	Lymphocytic_Thyroiditis	Chronic Lymphocytic Thyroiditis
C38768	Mucinous_Differentiation	Tissue_Differentiation	Mucinous Differentiation
C38769	Therapeutic_Tyrosinase-Related_Protein-2	Retired_Concepts	Recombinant Tyrosinase-Related Protein-2|TRP-2|Tyrosinase-Related Protein-2
C38770	Squamous_Differentiation	Epithelial_Differentiation	Squamous Differentiation
C38771	Benign_Neoplasms_of_Mouse_Liver	Mouse_Hepatic_System_Neoplasm	Benign Neoplasms of Mouse Liver
C38772	Malignant_Neoplasms_of_Mouse_Liver	Mouse_Hepatic_System_Neoplasm	Malignant Neoplasms of Mouse Liver
C38775	Alanine_and_Aspartate_Metabolism_Pathway	Amino_Acid_Metabolism_Pathway	Alanine and Aspartate Metabolism Pathway|Alanine and Aspartate Metabolism
C38776	Alkaloid_Biosynthesis_I_Pathway	Biosynthesis_of_Secondary_Metabolites_Pathway	Alkaloid Biosynthesis I Pathway|Alkaloid Biosynthesis I
C38777	Alkaloid_Biosynthesis_II_Pathway	Biosynthesis_of_Secondary_Metabolites_Pathway	Alkaloid Biosynthesis II Pathway|Alkaloid Biosynthesis II
C38778	Alzheimers_Disease_Pathway	Neurodegenerative_Disorders_Pathway	Alzheimer's Disease Pathway|Alzheimer's Disease
C38779	Aminoacyl-tRNA_Biosynthesis_Pathway	Genetic_Information_Processing_Pathway	Aminoacyl-tRNA Biosynthesis Pathway|Aminoacyl-tRNA Biosynthesis
C38780	Aminophosphonate_Metabolism_Pathway	Metabolic_Pathways_of_Other_Amino_Acids	Aminophosphonate Metabolism Pathway|Aminophosphonate Metabolism
C38781	Aminosugars_Metabolism_Pathway	Carbohydrate_Metabolism_Pathway	Aminosugars Metabolism Pathway|Aminosugars Metabolism
C38782	Amyotrophic_Lateral_Sclerosis_Pathway	Neurodegenerative_Disorders_Pathway	Amyotrophic Lateral Sclerosis Pathway|Amyotrophic Lateral Sclerosis (ALS)
C38783	Androgen_and_Estrogen_Metabolism_Pathway	Lipid_Metabolism_Reference_Pathway	Androgen and Estrogen Metabolism Pathway|Androgen and Estrogen Metabolism
C38784	Apoptosis_Pathway	Apoptosis_Regulation_Pathway	Apoptosis Pathway|Apoptosis
C38785	Arginine_and_Proline_Metabolism_Pathway	Amino_Acid_Metabolism_Pathway	Arginine and Proline Metabolism Pathway|Arginine and Proline Metabolism
C38786	Ascorbate_and_Aldarate_Metabolism_Pathway	Carbohydrate_Metabolism_Pathway	Ascorbate and Aldarate Metabolism Pathway|Ascorbate and Aldarate Metabolism
C38787	ATP_Synthesis_Pathway	Energy_Metabolism_Pathway	ATP Synthesis Pathway|ATP Synthesis
C38788	Beta-Alanine_Metabolism_Pathway	Metabolic_Pathways_of_Other_Amino_Acids	Beta-Alanine Metabolism Pathway|Beta-Alanine Metabolism
C38789	Bile_Acid_Biosynthesis_Pathway	Lipid_Metabolism_Reference_Pathway	Bile Acid Biosynthesis Pathway|Bile Acid Biosynthesis
C38790	Biotin_Metabolism_Pathway	Cofactors_and_Vitamins_Metabolism_Pathway	Biotin Metabolism Pathway|Biotin Metabolism
C38791	Blood_Group_Glycolipid_Biosynthesis_Lact_Series_Pathway	Glycan_Biosynthesis_and_Metabolism_Pathway	Blood Group Glycolipid Biosynthesis - Lact Series Pathway|Blood Group Glycolipid Biosynthesis - Lact Series
C38792	Blood_Group_Glycolipid_Biosynthesis_Neolact_Series_Pathway	Glycan_Biosynthesis_and_Metabolism_Pathway	Blood Group Glycolipid Biosynthesis - Neolact Series Pathway|Blood Group Glycolipid Biosynthesis - Neolact Series
C38793	Butanoate_Metabolism_Pathway	Carbohydrate_Metabolism_Pathway	Butanoate Metabolism Pathway|Butanoate Metabolism
C38794	Cell_Cycle_Pathway	Cell_Cycle_Regulation_Pathway	Cell Cycle Pathway|Cell Cycle
C38795	Chondroitin_Heparan_Sulfate_Biosynthesis_Pathway	Glycan_Biosynthesis_and_Metabolism_Pathway	Chondroitin/Heparan Sulfate Biosynthesis Pathway|Chondroitin / Heparan Sulfate Biosynthesis
C38796	Circadian_Rhythm_Pathway	Other_Biochemical_Pathway	Circadian Rhythm Pathway|Circadian Rhythm
C38797	Citrate_Cycle_TCA_Cycle_Pathway	Carbohydrate_Metabolism_Pathway	Citrate Cycle (TCA Cycle) Pathway|Citrate Cycle (TCA cycle)
C38798	Cyanoamino_Acid_Metabolism_Pathway	Metabolic_Pathways_of_Other_Amino_Acids	Cyanoamino Acid Metabolism Pathway|Cyanoamino Acid Metabolism
C38799	Cysteine_Metabolism_Pathway	Amino_Acid_Metabolism_Pathway	Cysteine Metabolism Pathway|Cysteine Metabolism
C38800	C21-Steroid_Hormone_Metabolism_Pathway	Lipid_Metabolism_Reference_Pathway	C21-Steroid Hormone Metabolism Pathway|C21-Steroid Hormone Metabolism
C38801	D-Alanine_Metabolism_Pathway	Metabolic_Pathways_of_Other_Amino_Acids	D-Alanine Metabolism Pathway|D-Alanine Metabolism
C38802	D-Arginine_and_D-Ornithine_Metabolism_Pathway	Metabolic_Pathways_of_Other_Amino_Acids	D-Arginine and D-Ornithine Metabolism Pathway|D-Arginine and D-Ornithine Metabolism
C38803	D-Glutamine_and_D-Glutamate_Metabolism_Pathway	Metabolic_Pathways_of_Other_Amino_Acids	D-Glutamine and D-Glutamate Metabolism Pathway|D-Glutamine and D-Glutamate Metabolism
C38804	Dentatorubropallidoluysian_Atrophy_Pathway	Apoptosis_Regulation_Pathway|Neurodegenerative_Disorders_Pathway	Dentatorubropallidoluysian Atrophy (DRPLA) Pathway|Dentatorubropallidoluysian Atrophy (DRPLA)
C38805	Fatty_Acid_Biosynthesis_Pathway_1	Lipid_Metabolism_Reference_Pathway	Fatty Acid Biosynthesis Pathway 1|Fatty Acid Biosynthesis (path 1)
C38806	Fatty_Acid_Biosynthesis_Pathway_2	Lipid_Metabolism_Reference_Pathway	Fatty Acid Biosynthesis Pathway 2|Fatty Acid Biosynthesis (path 2)
C38807	Fatty_Acid_Metabolism_Pathway	Lipid_Metabolism_Reference_Pathway	Fatty Acid Metabolism Pathway|Fatty Acid Metabolism
C38808	Flavonoids_Stilbene_and_Lignin_Biosynthesis_Pathway	Biosynthesis_of_Secondary_Metabolites_Pathway	Flavonoids, Stilbene and Lignin Biosynthesis Pathway|Flavonoids, Stilbene and Lignin Biosynthesis
C38809	Folate_Biosynthesis_Pathway	Cofactors_and_Vitamins_Metabolism_Pathway	Folate Biosynthesis Pathway|Folate Biosynthesis
C38810	Fructose_and_Mannose_Metabolism_Pathway	Carbohydrate_Metabolism_Pathway	Fructose and Mannose Metabolism Pathway|Fructose and Mannose Metabolism
C38811	Galactose_Metabolism_Pathway	Carbohydrate_Metabolism_Pathway	Galactose Metabolism Pathway|Galactose Metabolism
C38812	Ganglioside_Biosynthesis_Pathway	Glycan_Biosynthesis_and_Metabolism_Pathway	Ganglioside Biosynthesis Pathway|Ganglioside Biosynthesis
C38813	Globoside_Metabolism_Pathway	Glycan_Biosynthesis_and_Metabolism_Pathway	Globoside Metabolism Pathway|Globoside Metabolism
C38814	Glutamate_Metabolism_Pathway	Amino_Acid_Metabolism_Pathway	Glutamate Metabolism Pathway|Glutamate Metabolism
C38815	Glutathione_Metabolism_Pathway	Metabolic_Pathways_of_Other_Amino_Acids	Glutathione Metabolism Pathway|Glutathione Metabolism
C38816	Glycerolipid_Metabolism_Pathway	Lipid_Metabolism_Reference_Pathway	Glycerolipid Metabolism Pathway|Glycerolipid Metabolism
C38817	Glycine_Serine_and_Threonine_Metabolism_Pathway	Amino_Acid_Metabolism_Pathway	Glycine, Serine and Threonine Metabolism Pathway|Glycine, Serine and Threonine Metabolism
C38818	Glycolysis_Gluconeogenesis_Pathway	Carbohydrate_Metabolism_Pathway	Glycolysis/Gluconeogenesis Pathway|Glycolysis / Gluconeogenesis
C38819	Glycoprotein_Biosynthesis_Pathway	Metabolic_Pathways	Glycoprotein Biosynthesis Pathway|Glycoprotein Biosynthesis
C38820	Glycoprotein_Degradation_Pathway	Degradation_Pathway	Glycoprotein Degradation Pathway|Glycoprotein Degradation
C38821	Glycosaminoglycan_Degradation_Pathway	Glycan_Biosynthesis_and_Metabolism_Pathway	Glycosaminoglycan Degradation Pathway|Glycosaminoglycan Degradation
C38822	Glycosylphosphatidylinositol-anchor_Biosynthesis_Pathway	Glycan_Biosynthesis_and_Metabolism_Pathway	Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis Pathway|Glycosylphosphatidylinositol(GPI)-anchor Biosynthesis
C38823	Glyoxylate_and_Dicarboxylate_Metabolism_Pathway	Carbohydrate_Metabolism_Pathway	Glyoxylate and Dicarboxylate Metabolism Pathway|Glyoxylate and Dicarboxylate Metabolism
C38824	Histidine_Metabolism_Pathway	Amino_Acid_Metabolism_Pathway	Histidine Metabolism Pathway|Histidine Metabolism
C38825	Huntingtons_Disease_Pathway	Neurodegenerative_Disorders_Pathway	Huntington's Disease Pathway|Huntington's Disease
C38826	Indole_and_Ipecac_Alkaloid_Biosynthesis_Pathway	Biosynthesis_of_Secondary_Metabolites_Pathway	Indole and Ipecac Alkaloid Biosynthesis Pathway|Indole and Ipecac Alkaloid Biosynthesis
C38827	Inositol_Metabolism_Pathway	Carbohydrate_Metabolism_Pathway	Inositol Metabolism Pathway|Inositol Metabolism
C38828	Inositol_Phosphate_Metabolism_Pathway	Carbohydrate_Metabolism_Pathway	Inositol Phosphate Metabolism Pathway|Inositol Phosphate Metabolism
C38829	Integrin-mediated_Cell_Adhesion_Pathway	Cell_Motility_Pathway	Integrin-mediated Cell Adhesion Pathway|Integrin-mediated Cell Adhesion
C38830	Keratan_Sulfate_Biosynthesis_Pathway	Glycan_Biosynthesis_and_Metabolism_Pathway	Keratan Sulfate Biosynthesis Pathway|Keratan Sulfate Biosynthesis
C38831	Lipopolysaccharide_Biosynthesis_Pathway	Glycan_Biosynthesis_and_Metabolism_Pathway	Lipopolysaccharide Biosynthesis Pathway|Lipopolysaccharide Biosynthesis
C38832	Lysine_Biosynthesis_Pathway	Amino_Acid_Metabolism_Pathway	Lysine Biosynthesis Pathway|Lysine Biosynthesis
C38833	Lysine_Degradation_Pathway	Amino_Acid_Metabolism_Pathway|Degradation_Pathway	Lysine Degradation Pathway|Lysine Degradation
C38834	MAPK_Signaling_Pathway	Signaling_Pathways	MAPK Signaling Pathway Pathway|MAPK Signaling Pathway
C38835	Methane_Metabolism_Pathway	Energy_Metabolism_Pathway	Methane Metabolism Pathway|Methane Metabolism
C38836	Methionine_Metabolism_Pathway	Amino_Acid_Metabolism_Pathway	Methionine Metabolism Pathway|Methionine Metabolism
C38837	mRNA_Biosynthesis_Pathway	Genetic_Information_Processing_Pathway	mRNA Biosynthesis Pathway|mRNA Biosynthesis (Eukaryotes)
C38838	Nicotinate_and_Nicotinamide_Metabolism_Pathway	Cofactors_and_Vitamins_Metabolism_Pathway	Nicotinate and Nicotinamide Metabolism Pathway|Nicotinate and Nicotinamide Metabolism
C38839	Nitrogen_Metabolism_Pathway	Energy_Metabolism_Pathway	Nitrogen Metabolism Pathway|Nitrogen Metabolism
C38840	Nucleotide_Sugars_Metabolism_Pathway	Carbohydrate_Metabolism_Pathway	Nucleotide Sugars Metabolism Pathway|Nucleotide Sugars Metabolism
C38841	O-Glycans_Biosynthesis_Pathway	Glycan_Biosynthesis_and_Metabolism_Pathway	O-Glycans Biosynthesis Pathway|O-Glycans Biosynthesis
C38842	One_Carbon_Pool_by_Folate_Pathway	Cofactors_and_Vitamins_Metabolism_Pathway	One Carbon Pool by Folate Pathway|One Carbon Pool by Folate
C38843	Oxidative_Phosphorylation_Pathway	Energy_Metabolism_Pathway	Oxidative Phosphorylation Pathway|Oxidative Phosphorylation
C38844	Pantothenate_and_CoA_Biosynthesis_Pathway	Cofactors_and_Vitamins_Metabolism_Pathway	Pantothenate and CoA Biosynthesis Pathway|Pantothenate and CoA Biosynthesis
C38845	Parkinsons_Disease_Pathway	Neurodegenerative_Disorders_Pathway	Parkinson's Disease Pathway|Parkinson's Disease
C38846	Pentose_and_Glucuronate_Interconversions_Pathway	Carbohydrate_Metabolism_Pathway	Pentose and Glucuronate Interconversions Pathway|Pentose and Glucuronate Interconversions
C38847	Pentose_Phosphate_Cycle_Pathway	Carbohydrate_Metabolism_Pathway	Pentose Phosphate Cycle Pathway|Pentose Phosphate Cycle
C38848	Phenylalanine_Metabolism_Pathway	Amino_Acid_Metabolism_Pathway	Phenylalanine Metabolism Pathway|Phenylalanine Metabolism
C38849	Phenylalanine_Tyrosine_and_Tryptophan_Biosynthesis_Pathway	Amino_Acid_Metabolism_Pathway	Phenylalanine, Tyrosine and Tryptophan Biosynthesis Pathway|Phenylalanine, Tyrosine and Tryptophan Biosynthesis
C38850	Phosphatidylinositol_Signaling_System_Pathway	Signaling_Pathways	Phosphatidylinositol Signaling System Pathway|Phosphatidylinositol Signaling System
C38851	Phospholipid_Degradation_Pathway	Degradation_Pathway|Lipid_Metabolism_Reference_Pathway	Phospholipid Degradation Pathway|Phospholipid Degradation
C38852	Porphyrin_and_Chlorophyll_Metabolism_Pathway	Cofactors_and_Vitamins_Metabolism_Pathway	Porphyrin and Chlorophyll Metabolism Pathway|Porphyrin and Chlorophyll Metabolism
C38853	Prion_Disease_Pathway	Neurodegenerative_Disorders_Pathway	Prion Disease Pathway|Prion Disease
C38854	Propanoate_Metabolism_Pathway	Carbohydrate_Metabolism_Pathway	Propanoate Metabolism Pathway|Propanoate Metabolism
C38855	Prostaglandin_and_Leukotriene_Metabolism_Pathway	Lipid_Metabolism_Reference_Pathway	Prostaglandin and Leukotriene Metabolism Pathway|Prostaglandin and Leukotriene Metabolism
C38856	Protein_Biosynthesis_Pathway	Genetic_Information_Processing_Pathway	Protein Biosynthesis Pathway|Protein Biosynthesis (Eukaryotes)
C38857	Protein_Export_Pathway	Genetic_Information_Processing_Pathway	Protein Export Pathway|Protein Export
C38858	Purine_Metabolism_Pathway	Nucleotide_Metabolism_Pathway	Purine Metabolism Pathway|Purine Metabolism
C38859	Pyrimidine_Metabolism_Pathway	Nucleotide_Metabolism_Pathway	Pyrimidine Metabolism Pathway|Pyrimidine Metabolism
C38860	Pyruvate_Metabolism_Pathway	Carbohydrate_Metabolism_Pathway	Pyruvate Metabolism Pathway|Pyruvate Metabolism
C38861	Retinol_Metabolism_Pathway	Cofactors_and_Vitamins_Metabolism_Pathway	Retinol Metabolism Pathway|Retinol Metabolism
C38862	Riboflavin_Metabolism_Pathway	Cofactors_and_Vitamins_Metabolism_Pathway	Riboflavin Metabolism Pathway|Riboflavin Metabolism
C38863	rRNA_Biosynthesis_Eukaryotes_Pathway	Genetic_Information_Processing_Pathway	rRNA Biosynthesis Pathway|rRNA Biosynthesis (Eukaryotes)
C38864	Selenoamino_Acid_Metabolism_Pathway	Metabolic_Pathways_of_Other_Amino_Acids	Selenoamino Acid Metabolism Pathway|Selenoamino Acid Metabolism
C38865	Sphingoglycolipid_Metabolism_Pathway	Metabolic_Pathways	Sphingoglycolipid Metabolism Pathway|Sphingoglycolipid Metabolism
C38866	Sphingophospholipid_Biosynthesis_Pathway	Metabolic_Pathways	Sphingophospholipid Biosynthesis Pathway|Sphingophospholipid Biosynthesis
C38867	Starch_and_Sucrose_Metabolism_Pathway	Carbohydrate_Metabolism_Pathway	Starch and Sucrose Metabolism Pathway|Starch and Sucrose Metabolism
C38868	Sterol_Biosynthesis_Pathway	Metabolic_Pathways	Sterol Biosynthesis Pathway|Sterol Biosynthesis
C38869	Sulfur_Metabolism_Pathway	Energy_Metabolism_Pathway	Sulfur Metabolism Pathway|Sulfur Metabolism
C38870	Synthesis_and_Degradation_of_Ketone_Bodies_Pathway	Lipid_Metabolism_Reference_Pathway	Synthesis and Degradation of Ketone Bodies Pathway|Synthesis and Degradation of Ketone Bodies
C38871	Taurine_and_Hypotaurine_Metabolism_Pathway	Metabolic_Pathways_of_Other_Amino_Acids	Taurine and Hypotaurine Metabolism Pathway|Taurine and Hypotaurine Metabolism
C38872	Terpenoid_Biosynthesis_Pathway	Biosynthesis_of_Secondary_Metabolites_Pathway	Terpenoid Biosynthesis Pathway|Terpenoid Biosynthesis
C38873	Thiamin_Metabolism_Pathway	Cofactors_and_Vitamins_Metabolism_Pathway	Thiamin Metabolism Pathway|Thiamin Metabolism
C38874	tRNA_Biosynthesis_Eukaryotes_Pathway	Genetic_Information_Processing_Pathway	tRNA Biosynthesis Pathway|tRNA Biosynthesis (Eukaryotes)
C38875	Tryptophan_Metabolism_Pathway	Amino_Acid_Metabolism_Pathway	Tryptophan Metabolism Pathway|Tryptophan Metabolism
C38876	Type_II_Secretion_System_Pathway	Genetic_Information_Processing_Pathway	Type II Secretion System Pathway|Type II Secretion System
C38877	Type_III_Secretion_System_Pathway	Genetic_Information_Processing_Pathway	Type III Secretion System Pathway|Type III Secretion System
C38878	Type_IV_Secretion_System_Pathway	Genetic_Information_Processing_Pathway	Type IV Secretion System Pathway|Type IV Secretion System
C38879	Tyrosine_Metabolism_Pathway	Amino_Acid_Metabolism_Pathway	Tyrosine Metabolism Pathway|Tyrosine Metabolism
C38880	Ubiquinone_Biosynthesis_Pathway	Cofactors_and_Vitamins_Metabolism_Pathway	Ubiquinone Biosynthesis Pathway|Ubiquinone Biosynthesis
C38881	Ubiquitin-mediated_Proteolysis_Pathway	Degradation_Pathway|Genetic_Information_Processing_Pathway	Ubiquitin-mediated Proteolysis Pathway|Ubiquitin-mediated Proteolysis
C38882	Urea_Cycle_and_Metabolism_of_Amino_Groups_Pathway	Amino_Acid_Metabolism_Pathway	Urea Cycle and Metabolism of Amino Groups Pathway|Urea Cycle and Metabolism of Amino Groups
C38883	Valine_Leucine_and_Isoleucine_Biosynthesis_Pathway	Amino_Acid_Metabolism_Pathway	Valine, Leucine and Isoleucine Biosynthesis Pathway|Valine, Leucine and Isoleucine Biosynthesis
C38884	Valine_Leucine_and_Isoleucine_Degradation_Pathway	Amino_Acid_Metabolism_Pathway|Degradation_Pathway	Valine, Leucine and Isoleucine Degradation Pathway|Valine, Leucine and Isoleucine Degradation
C38885	Vitamin_B6_Metabolism_Pathway	Cofactors_and_Vitamins_Metabolism_Pathway	Vitamin B6 Metabolism Pathway|Vitamin B6 Metabolism
C38886	CD19_Gene	Adaptor_Signaling_Protein_Gene	CD19 Gene|B4|CD19|CD19 Antigen Gene	Expressed by early B-cells, human CD19 Gene (Ig Superfamily) encodes 95-kDa CD19_Antigen, a type I cell surface protein with 2 extracellular IgC2 domains, a cytoplasmic tail with 9 conserved Tyr residues, and no significant homology with other known proteins. Assembled with BCR, CD19 decreases the threshold for antigen receptor-dependent stimulation of B lymphocyte proliferation and intersects with many intracellular signaling pathways. CD19 functions as an adaptor protein for Src family kinase amplification, crucial for antigen receptor-induced signal transduction. Following BCR/CD19 ligation, LYN (Src kinase) phosphorylates CD19-Y513, binds to the CD19-SH2 domain and phosphorylates CD19-Y482. CD19-pY482 recruits more LYN, leading to LYN phosphorylation and CD19-Y391 phosphorylation. CD19-pY391 recruits VAV, phosphorylated by LYN. (NCI)
C38887	_11q12	Chromosome_Band	11q12	A chromosome band present on 11q
C38888	_1p36_2	Chromosome_Band	1p36.2	A chromosome band present on 1p
C38889	_2q12-q22	Chromosome_Band	2q12-q22	A chromosome band present on 2q
C38890	_3p21_2	Chromosome_Band	3p21.2	A chromosome band present on 3p
C38891	_6p11_2	Chromosome_Band	6p11.2	A chromosome band present on 6p
C38892	_7q31_3-q32	Chromosome_Band	7q31.3-q32	A chromosome band present on 7q
C38893	_9p13-p12	Chromosome_Band	9p13-p12	A chromosome band present on 9p
C38894	CD19_Antigen	Adaptor_Signaling_Protein	CD19 Antigen|B-Lymphocyte Antigen CD19|B-Lymphocyte Surface Antigen B4|B4|CD19|Differentiation Antigen CD19|Leu-12	Expressed on early B-cells by human CD19 Gene (Ig Superfamily), 95-kDa CD19_Antigen is a type I cell surface protein with 2 extracellular IgC2 domains, a cytoplasmic tail with 9 conserved Tyr residues, and no significant homology with other known proteins. Assembled with BCR, CD19 decreases the threshold for antigen receptor-dependent stimulation of B lymphocyte proliferation and intersects with many intracellular signaling pathways. CD19 functions as an adaptor protein for Src family kinase amplification, crucial for antigen receptor-induced signal transduction. Following BCR/CD19 ligation, LYN (Src kinase) phosphorylates CD19-Y513, binds to the CD19-SH2 domain and phosphorylates CD19-Y482. CD19-pY482 recruits more LYN, leading to LYN phosphorylation and CD19-Y391 phosphorylation. CD19-pY391 recruits VAV, phosphorylated by LYN. (NCI)
C38895	MS4A1_Gene	Immunoprotein_Gene	MS4A1 Gene|B1|Bp35|CD20|LEU-16|MS4A1|MS4A2|Membrane-Spanning 4-Domains, Subfamily A, Member 1 Gene|S7	Expressed during B-cell ontogeny (early pre-B-cell to plasma cell), 8-exon 16-kb human CD20 Gene (MS4A Family) encodes 297-aa 33-kDa CD20 Antigen, a phosphorylated cell surface integral membrane protein shown to participate in B-cell proliferation, development, and differentiation into plasma cells. MS4A family genes/proteins share structural similarity, sequence homology, similar intron/exon splice boundaries, chromosomal location, and unique expression patterns among hematopoietic cells and nonlymphoid tissues. MS4A proteins contain 4 highly conserved transmembrane domains, flanked by N- and C-terminal cytoplasmic regions. CD20 may be involved in regulation of B-cell activation and may be regulated by protein kinases. (NCI)
C38896	CD20_Antigen	Immunoprotein	CD20 Antigen|B-Lymphocyte Antigen CD20|B-Lymphocyte Surface Antigen B1|B1|Bp35|CD20 Receptor|Leu-16|MS4A1|Membrane-Spanning 4-Domains Subfamily A Member 1	Expressed during B-cell ontogeny (early pre-B-cell to plasma cell) by human CD20 Gene (MS4A Family), 297-aa 33-kDa CD20 Antigen is a phosphorylated cell surface integral membrane protein shown to participate in B-cell proliferation, development, and differentiation into plasma cells. MS4A family proteins share structural similarity, sequence homology, and unique expression patterns among hematopoietic cells and nonlymphoid tissues. MS4A proteins contain 4 highly conserved transmembrane domains, flanked by N- and C-terminal cytoplasmic regions. CD20 may be involved in regulation of B-cell activation and may be regulated by protein kinases. (NCI)
C38897	CD3_Complex	Protein_or_Riboprotein_Complex	CD3 Complex|CD3	Consisting of cell surface type I membrane Delta, Epsilon, Gamma, Zeta, and Eta protein subunits with ITAM domains and noncovalently associated with the disulfide bound heterodimeric alpha/beta and gamma/delta TCR, the CD3 complex couples receptor antigen recognition to signal transduction pathways during T-cell activation. During TCR engagement with MHC-associated antigen on host cell surfaces and synapse formation, CD3 activity leads to Tyr-phosphorylated CD3 subunits, Tyr phosphorylation of LAT colocalized in lipid rafts, and MAPK activation. CD3 signal transduction appears to involve LCK, ZAP70, Nck, SLA, SLA2, and DOCK2. CD3 subunits may also associate with the cytoskeleton. CD3 also mediates TCR signal transduction during the developmental transition through positive selection of immature thymocytes to mature CD4+ or CD8+ T cells. (NCI)
C38898	CD3D_Gene	Protein_Complex_Subunit_Gene	CD3D Gene|CD3D|CD3D Antigen, Delta Polypeptide (TIT3 Complex) Gene|T3D	The 5-exon 4-kb human CD3D Gene encodes 171-aa 19-kDa (precursor) T-Cell Receptor-T3 Delta Chain, a cell surface type I membrane protein containing 1 ITAM domain and subunit of the CD3 complex (CD3D, CD3E, CD3G, CD3Zeta/Eta) noncovalently associated with the disulfide bound heterodimeric alpha/beta and gamma/delta TCR. Mediating signal transduction, CD3 complex plays an important role in the developmental transition of immature thymocytes to mature CD4+ or CD8+ T cells. Immature thymocytes in the thymus that recognize self-MHC survive and differentiate through positive selection; self-reactive thymocytes are removed through negative selection. Following TCR engagement, CD3D activity leads to tyrosine-phosphorylated CD3Z, tyrosine phosphorylation of colocalized LAT in lipid rafts, MAPK3 or MAPK8 activation, and positive selection. (NCI)
C38899	T-Cell_Receptor-T3_Delta_Chain	Protein_Complex_Subunit	T-Cell Receptor T3 Delta Chain|CD3 Delta|CD3D|T-Cell Surface Glycoprotein CD3 Delta Chain|T3D|TiT3 Complex CD3D Antigen Delta Polypeptide	Encoded by CD3D Gene, 171-aa 19-kDa (precursor) T-Cell Receptor-T3 Delta Chain is a cell surface type I membrane protein containing 1 ITAM domain and subunit of the CD3 complex (CD3D, CD3E, CD3G, CD3Zeta/Eta) noncovalently associated with the disulfide bound heterodimeric alpha/beta and gamma/delta TCR. Mediating signal transduction, CD3 complex plays an important role in the developmental transition of immature thymocytes to mature CD4+ or CD8+ T cells. Immature thymocytes in the thymus that recognize self-MHC survive and differentiate through positive selection; self-reactive thymocytes are removed through negative selection. Following TCR engagement, CD3D activity leads to tyrosine-phosphorylated CD3Z, tyrosine phosphorylation of colocalized LAT in lipid rafts, MAPK3 or MAPK8 activation, and positive selection. (NCI)
C38900	CD3G_Gene	Protein_Complex_Subunit_Gene	CD3G Gene|CD3G|CD3G Antigen, Gamma Polypeptide (TIT3 Complex) Gene|T3G	The 7-exon 9-kb human CD3G Gene encodes 182-aa 20.5-kDa (precursor) T-Cell Receptor-T3 Gamma Chain, a cell surface type I membrane protein similar to CD3D containing an Ig-like domain and a ITAM domain and subunit of the CD3 complex (CD3D, CD3E, CD3G, CD3Zeta/Eta) noncovalently associated with disulfide bound alpha/beta and gamma/delta TCR. Mediating signal transduction, CD3 plays a role in the transition of immature thymocytes to mature CD4+ or CD8+ T cells. Immature thymocytes that recognize self-MHC survive and differentiate through positive selection; self-reactive thymocytes are removed through negative selection. Following TCR engagement with MHC-associated antigen on host cell surfaces, CD3 activity leads to T-cell activation. CD3G defects are associated with T cell immunodeficiency. (NCI)
C38901	T-Cell_Receptor-T3_Gamma_Chain	Protein_Complex_Subunit	T-Cell Receptor T3 Gamma Chain	Encoded by human CD3G Gene, 182-aa 20.5-kDa (precursor) T-Cell Receptor-T3 Gamma Chain is a cell surface type I membrane protein similar to CD3D containing an Ig-like domain and a ITAM domain and subunit of the CD3 complex (CD3D, CD3E, CD3G, CD3Zeta/Eta) noncovalently associated with disulfide bound alpha/beta and gamma/delta TCR. Mediating signal transduction, CD3 plays a role in the transition of immature thymocytes to mature CD4+ or CD8+ T cells. Immature thymocytes that recognize self-MHC survive and differentiate through positive selection; self-reactive thymocytes are removed through negative selection. Following TCR engagement with MHC-associated antigen on host cell surfaces, CD3 activity leads to T-cell activation. CD3G defects are associated with T cell immunodeficiency. (NCI)
C38902	CD3Z_Gene	Protein_Complex_Subunit_Gene	CD3Z Gene|CD3Z|CD3Z Antigen, Zeta Polypeptide (TIT3 Complex) Gene|T3Z|TCRZ	T-cell specific human CD3Z Gene (CD3Z/FCER1G Family) encodes alternative isoforms of conserved nonglycosylated T-Cell Receptor-T3 Zeta/Eta Chain, a cell surface type I membrane protein containing 3 ITAM domains and subunit of the CD3 complex (CD3D, CD3E, CD3G, CD3Zeta/Eta) noncovalently associated with disulfide bound alpha/beta and gamma/delta TCR. CD3-zeta forms disulfide-linked homodimers or heterodimers with CD3-eta, couples antigen recognition to signal transduction pathways, and may be associated with the cytoskeleton. CD3Z interacts with SLA, SLA2, and DOCK2. Enhancing T-cell antigen sensitivity, accessory protein CD4 binds to MHC II molecules and to LCK, which phosphorylates CD3Z. CD3 plays a role in the transition of immature thymocytes to mature CD4+ or CD8+ T cells. Following TCR engagement, CD3 activity leads to T-cell activation. (NCI)
C38903	T-Cell_Receptor-T3_Zeta_Chain	Protein_Complex_Subunit	T-Cell Receptor T3 Zeta Chain	Encoded as alternative isoforms by T-cell specific human CD3Z Gene (CD3Z/FCER1G Family), conserved nonglycosylated T-Cell Receptor-T3 Zeta Chain is a cell surface type I membrane protein containing 3 ITAM domains and a subunit of the CD3 complex (CD3D, CD3E, CD3G, CD3Zeta/Eta) noncovalently associated with disulfide bound alpha/beta and gamma/delta TCR. CD3-zeta forms disulfide-linked homodimers or heterodimers with CD3-eta, couples antigen recognition to signal transduction pathways, and may be associated with the cytoskeleton. CD3Z interacts with SLA, SLA2, and DOCK2. Enhancing T-cell antigen sensitivity, accessory protein CD4 binds to MHC II molecules and to LCK, which phosphorylates CD3Z. CD3 plays a role in the transition of immature thymocytes to mature CD4+ or CD8+ T cells. Following TCR engagement, CD3 activity leads to T-cell activation. (NCI)
C38904	T-Cell_Receptor-T3_Eta_Chain	Protein_Complex_Subunit	T-Cell Receptor T3 Eta Chain	Encoded as alternative isoforms by T-cell specific human CD3Z Gene (CD3Z/FCER1G Family), conserved nonglycosylated T-Cell Receptor-T3 Eta Chain is a cell surface type I membrane protein containing 3 ITAM domains and a subunit of the CD3 complex (CD3D, CD3E, CD3G, CD3Zeta/Eta) noncovalently associated with disulfide bound alpha/beta and gamma/delta TCR. CD3-zeta forms disulfide-linked homodimers or heterodimers with CD3-eta, couples antigen recognition to signal transduction pathways, and may be associated with the cytoskeleton. CD3Z interacts with SLA, SLA2, and DOCK2. Enhancing T-cell antigen sensitivity, accessory protein CD4 binds to MHC II molecules and to LCK, which phosphorylates CD3Z. CD3 plays a role in the transition of immature thymocytes to mature CD4+ or CD8+ T cells. Following TCR engagement, CD3 activity leads to T-cell activation. (NCI)
C38905	TNFRSF8_Gene	TNF_Receptor_Family_Gene	TNFRSF8 Gene|CD30|KI-1|TNFRSF8|Tumor Necrosis Factor Receptor Superfamily, Member 8 Gene	Expressed by activated T- and B-cells, human TNFRSF8 Gene (TNFR Superfamily) encodes distinct serine and tyrosine phosphorylated Long (595-aa, 64-kDa precursor type I membrane protein) and Short (cytoplasmic) isoforms of TNF Receptor 8, containing 6 TNFR-Cys repeats. A positive regulator of apoptosis and receptor for TNFSF8/CD30L, TNFRSF8 interacts with the TRAF1, TRAF2, TRAF3, and TRAF5 mediators of signal transduction and regulates gene expression through NF-Kappa-B activation. A Hodgkin's disease associated antigen, TNFRSF8 limits the proliferative potential of autoreactive CD8 effector T cells and protects against autoimmunity. (NCI)
C38906	TNF_Receptor-8	TNF_Receptor_Family_Protein	TNF Receptor 8|CD30 Antigen	Expressed in activated T- and B-cells by human TNFRSF8 Gene (TNFR Superfamily) as distinct serine and tyrosine phosphorylated Long (595-aa, 64-kDa precursor type I membrane protein) and Short (cytoplasmic) isoforms, TNF Receptor 8 contains 6 TNFR-Cys repeats. A positive regulator of apoptosis and receptor for TNFSF8/CD30L, TNFRSF8 interacts with the TRAF1, TRAF2, TRAF3, and TRAF5 mediators of signal transduction and regulates gene expression through NF-Kappa-B activation. A Hodgkin's disease associated antigen, TNFRSF8 limits the proliferative potential of autoreactive CD8 effector T cells and protects against autoimmunity. (NCI)
C38907	CD52_Gene	Immunoprotein_Gene	CDW52 Gene|CD52|CD52 Antigen (CAMPATH-1 Antigen) Gene|CDW52|HE5	Expressed by lymphocytes and monocytes, human CD52 Gene encodes 61-aa 6.6-kDa (precursor) CD52 Antigen, having 37-aa residues plus a 24-aa signal peptide and membrane attached by a glycosylphosphatidylinositol (GPI) anchor. HE5, the peptide backbone of CDW52, is highly expressed in the distal corpus epididymis and in the vas deferens. (NCI)
C38908	CD52_Antigen	Immunoprotein	CDW52 Antigen|CAMPATH-1 Antigen|CDW52	Expressed on lymphocytes and monocytes by human CD52 Gene, 61-aa 6.6-kDa (precursor) CD52 Antigen has 37-aa residues plus a 24-aa signal peptide and is membrane attached by a glycosylphosphatidylinositol (GPI) anchor. HE5, the peptide backbone of CDW52, is highly expressed in the distal corpus epididymis and in the vas deferens. (NCI)
C38909	GNRHR_Gene	G_Protein-Coupled_Receptor_Gene	GNRHR Gene|GNRHR|GRHR|Gonadotropin-Releasing Hormone Receptor Gene|LHRHR	Expressed in pituitary, ovary, testis, breast, and prostate, 3-exon 19-kb single copy human GNRHR Gene (GPCR1 Family) encodes 2 alternative isoforms of Gonadotropin-Releasing Hormone Receptor, a cell surface G protein-coupled 7-transmembrane-domain receptor that transduces signals from hypothalamic decapeptide GNRH by association with G proteins that activate a calcium-phosphatidylinositol second messenger system. A neuroregulator of reproduction, the primary site of GNRH action is pituitary gonadotropes, which express GNRH receptors that modulate synthesis and secretion of gonadotropic hormones LH and FSH, which regulate gametogenic and hormonal functions of gonads. GNRHR Isoform 2 may act as an inhibitor of GNRHR signaling. (NCI)
C38910	Gonadotropin-Releasing_Hormone_Receptor	G_Protein-Coupled_Receptor	Gonadotropin-Releasing Hormone Receptor	Expressed as 2 alternative isoforms in pituitary, ovary, testis, breast, and prostate by human GNRHR Gene (GPCR1 Family), Gonadotropin-Releasing Hormone Receptor is a cell surface G protein-coupled 7-transmembrane-domain receptor that transduces signals from hypothalamic decapeptide GNRH by association with G proteins that activate a calcium-phosphatidylinositol second messenger system. A neuroregulator of reproduction, the primary site of GNRH action is pituitary gonadotropes, which express GNRH receptors that modulate synthesis and secretion of gonadotropic hormones LH and FSH, which regulate gametogenic and hormonal functions of gonads. GNRHR Isoform 2 may act as an inhibitor of GNRHR signaling. (NCI)
C38911	IL1R1_Gene	Cytokine_Receptor_Gene	IL1R1 Gene|IL1R|IL1R1|IL1RA|Interleukin 1 Receptor, Type I Gene	Human IL1R1 Gene (IL1R Family) encodes 569-aa 65-kDa (precursor) Interleukin 1Receptor Alpha Type I, a type I membrane protein cytokine receptor for IL1A, IL1B, and IL1R1/IL1RA that binds to IL1RAP and contains 3 IgC2 domains and 1 TIR domain. An important mediator in many cytokine induced immune and inflammatory responses, agonist binding by IL1R1 leads to formation of a ternary signaling complex of IL1RAP/TOLLIP/MYD88/IRAK1 (or IRAK2) and NF-Kappa-B activation. (NCI)
C38912	Interleukin-1-Receptor_Alpha_Type-I	Cytokine_Receptor	Interleukin-1 Receptor Alpha Type-I	Encoded by human IL1R1 Gene (IL1R Family), 569-aa 65-kDa (precursor) Interleukin-1 Receptor Alpha Type I is a type I membrane protein cytokine receptor for IL1A, IL1B, and IL1R1/IL1RA that binds to IL1RAP and contains 3 IgC2 domains and 1 TIR domain. An important mediator in many cytokine induced immune and inflammatory responses, agonist binding by IL1R1 leads to formation of a ternary signaling complex of IL1RAP/TOLLIP/MYD88/IRAK1 (or IRAK2) and NF-Kappa-B activation. (NCI)
C38913	IL1R2_Gene	Cytokine_Receptor_Gene	IL1R2 Gene|IL1R2|IL1RB|Interleukin 1 Receptor, Type II Gene	Human IL1R2 Gene (IL1R Family) encodes 398-aa 45-kDa (precursor) Interleukin 1 Receptor Beta Type II, a type I membrane protein decoy cytokine receptor that contains 3 IgC2 domains and inhibits the activity of its ligands IL1A, IL1B, and IL1R1/IL1RA. (NCI)
C38914	Interleukin-1-Receptor_Beta_Type-II	Cytokine_Receptor	Interleukin-1 Receptor Beta Type-II	Encoded by human IL1R2 Gene (IL1R Family), 398-aa 45-kDa (precursor) Interleukin 1 Receptor Beta Type II is a type I membrane protein decoy cytokine receptor that contains 3 IgC2 domains and inhibits the activity of its ligands IL1A, IL1B, and IL1R1/IL1RA. (NCI)
C38915	Interleukin-12_Receptor	Protein_or_Riboprotein_Complex	Interleukin 12 Receptor	Human high affinity Interleukin 12 Receptor is composed of Interleukin 12 Receptor Beta 1 Chain (I12RB1) and Interleukin 12 Receptor Beta 2 Chain (IL12RB2), each a type I transmembrane disulfide-linked dimer/oligomer protein containing 5 FNIII domains, a box 1 motif required for JAK interaction/activation, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. Involved in IL12 signal transduction, IL12RB1 and IL12RB2 oligomers act as low affinity IL12 receptors. (NCI)
C38916	IL12RB1_Gene	Protein_Complex_Subunit_Gene	IL12RB1 Gene|IL12R|IL12RB|IL12RB1|Interleukin 12 Receptor, Beta 1 Gene	Human IL12RB1 Gene (Type I Cytokine Receptor 2 Family) encodes 2 alternative isoforms of Interleukin 12 Receptor Beta 1 Chain, a type I transmembrane disulfide-linked dimer/oligomer protein containing 5 FNIII domains, a box 1 motif required for JAK interaction/activation, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. Involved in IL12 signal transduction, IL12RB1 oligomers act as a low affinity IL12 receptor; the high affinity IL12 receptor is composed of I12RB1 and IL12RB2. IL12RB1 defects cause mycobacterial and Salmonella susceptibility. (NCI)
C38917	Interleukin-12-Receptor_Beta-1-Chain	Protein_Complex_Subunit	Interleukin-12 Receptor Beta-1 Chain	Human IL12RB1 Gene (Type I Cytokine Receptor 2 Family) encodes 2 alternative isoforms of Interleukin 12 Receptor Beta 1 Chain, a type I transmembrane disulfide-linked dimer/oligomer protein containing 5 FNIII domains, a box 1 motif required for JAK interaction/activation, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. Involved in IL12 signal transduction, IL12RB1 oligomers act as a low affinity IL12 receptor; the high affinity IL12 receptor is composed of I12RB1 and IL12RB2. IL12RB1 defects cause mycobacterial and Salmonella susceptibility. (NCI)
C38918	IL12RB2_Gene	Protein_Complex_Subunit_Gene	IL12RB2 Gene|IL12RB2|Interleukin 12 Receptor, Beta 2 Gene	Induced by interferon gamma in Th1 cells, human IL12RB2 Gene (Type I Cytokine Receptor 2 Family) encodes 862-aa 97-kDa (precursor) Interleukin 12 Receptor Beta 2 Chain, a type I transmembrane disulfide-linked dimer/oligomer protein containing 5 FNIII domains, a box 1 motif required for JAK interaction/activation, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. Involved in Th1 cell differentiation and IL12 signal transduction, IL12RB2 oligomers act as a low affinity IL12 receptor; the high affinity IL12 receptor is composed of IL12RB2 and I12RB1. IL12RB2 expression is associated with several infectious diseases and may contribute to host defense and the inflammatory response. (NCI)
C38919	Interleukin-12-Receptor_Beta-2-Chain	Protein_Complex_Subunit	Interleukin-12 Receptor Beta-2 Chain	Encoded by interferon gamma-induced human IL12RB2 Gene (Type I Cytokine Receptor 2 Family), 862-aa 97-kDa (precursor) Interleukin 12 Receptor Beta 2 Chain is a type I transmembrane disulfide-linked dimer/oligomer protein containing 5 FNIII domains, a box 1 motif required for JAK interaction/activation, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. Involved in Th1 cell differentiation and IL12 signal transduction, IL12RB2 oligomers act as a low affinity IL12 receptor; the high affinity IL12 receptor is composed of IL12RB2 and I12RB1. IL12RB2 expression is associated with several infectious diseases and may contribute to host defense and the inflammatory response. (NCI)
C38920	IL6R_Gene	Cytokine_Receptor_Gene	IL6R Gene|IL6R1|Interleukin 6 Receptor Gene	Expressed as a type I membrane protein (isoform 1) and as a secreted (isoform 2) protein (peripheral blood mononuclear cells), human IL6R_Gene (Type I Cytokine Receptor 3 Family) encodes Interleukin 6 Receptor Alpha Subunit, containing an IgC2 domain, 2 FNIII cytokine-binding domains, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. A soluble IL6R may be released from the membrane by proteolysis. The IL6R subunit of the IL6 receptor complex binds to the potent pleiotropic cytokine IL6 with low affinity, but does not transduce a signal. Signal activation requires association with IL6ST, shared by other cytokine receptors, leading to regulation of the immune response, acute-phase reactions, and hematopoiesis. IL6R dysregulation is implicated in the pathogenesis of multiple myeloma, autoimmune disease, and prostate cancer. (NCI)
C38921	Interleukin-6-Receptor_Alpha_Subunit	Cytokine_Receptor	Interleukin-6 Receptor Alpha Subunit	Expressed as a type I membrane protein (isoform 1) and as a secreted (isoform 2) protein (peripheral blood mononuclear cells) by human IL6R_Gene (Type I Cytokine Receptor 3 Family), Interleukin 6 Receptor Alpha Subunit contains an IgC2 domain, 2 FNIII cytokine-binding domains, and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. A soluble IL6R may be released from the membrane by proteolysis. The IL6R subunit of the IL6 receptor complex binds to the potent pleiotropic cytokine IL6 with low affinity, but does not transduce a signal. Signal activation requires association with IL6ST, shared by other cytokine receptors, leading to regulation of the immune response, acute-phase reactions, and hematopoiesis. IL6R dysregulation is implicated in the pathogenesis of multiple myeloma, autoimmune disease, and prostate cancer. (NCI)
C38922	IMPDH1_Gene	Oxidoreductase_Gene	IMPDH1 Gene|IMP (Inosine Monophosphate) Dehydrogenase 1 Gene|IMPD|IMPD1|IMPDH1	Expressed as 2 alternative isoforms, human IMPDH1 Gene (IMPDH/GMPR Family) encodes conserved homotetrameric IMP Dehydrogenase 1, the rate-limiting enzyme in de novo guanine nucleotide synthesis and containing 2 CBS domains. Positioned at the branch point in adenine/guanine purine de novo synthesis, IMPDH1 catalyzes formation of xanthine monophosphate (XMP) from IMP, the first step in GMP biosynthesis from IMP. Involved in regulation of cell proliferation, inhibition of IMPDH1 activity blocks DNA synthesis and the cell cycle at the G1-S interface. IMPDH1 defects cause RP10. (NCI)
C38923	IMP-Dehydrogenase-1	Oxidoreductase	IMP Dehydrogenase 1	Expressed as 2 alternative isoforms by human IMPDH1 Gene (IMPDH/GMPR Family), conserved homotetrameric IMP Dehydrogenase 1 is the rate-limiting enzyme in de novo guanine nucleotide synthesis and contains 2 CBS domains. Positioned at the branch point in adenine/guanine purine de novo synthesis, IMPDH1 catalyzes formation of xanthine monophosphate (XMP) from IMP, the first step in GMP biosynthesis from IMP. Involved in regulation of cell proliferation, inhibition of IMPDH1 activity blocks DNA synthesis and the cell cycle at the G1-S interface. IMPDH1 defects cause RP10. (NCI)
C38924	IMPDH2_Gene	Oxidoreductase_Gene	IMPDH2 Gene|IMP (Inosine Monophosphate) Dehydrogenase 2 Gene|IMPD2|IMPDH2	The 14-exon 6-kb human IMPDH2 Gene (IMPDH/GMPR Family) encodes homotetrameric 514-aa 56-kDa IMP Dehydrogenase 2, the rate-limiting enzyme in de novo guanine nucleotide synthesis containing 2 CBS domains and a blocked N-terminus. Involved in regulation of cell proliferation, IMPDH2 catalyzes the first step in GMP biosynthesis from IMP. (NCI)
C38925	IMP-Dehydrogenase-2	Oxidoreductase	IMP Dehydrogenase 2	Encoded by 14-exon 6-kb human IMPDH2 Gene (IMPDH/GMPR Family), homotetrameric 514-aa 56-kDa IMP Dehydrogenase 2 is the rate-limiting enzyme in de novo guanine nucleotide synthesis, contains 2 CBS domains, and contains a blocked N-terminus. Involved in regulation of cell proliferation, IMPDH2 catalyzes the first step in GMP biosynthesis from IMP. (NCI)
C38926	CAD_Gene	Transferase_Gene	CAD Gene|CAD|Carbamoyl-Phosphate Synthetase 2, Aspartate Transcarbamylase, and Dihydroorotase Gene	Human CAD Gene (DHOase Family) encodes a trifunctional homohexameric cytoplasmic 2225-aa 243-kDa protein associated with the first 3 enzymatic activities of the 6-step de novo pyrimidine nucleotide biosynthesis pathway: Carbamoylphosphate Synthetase (GD-CPSASE), Aspartate Carbamoyltransferase, and Dihydroorotase, containing a CPSase domain and a type-1 glutamine amidotransferase domain. PRPP is a CAD activator and UMP is an inhibitor of CPSase. CAD is directly regulated allosterically by phosphorylation from the MAPK cascade. (NCI)
C38927	Aspartate_Carbamoyltransferase	Transferase	Aspartate Carbamoyltransferase	Human CAD Gene (DHOase Family) encodes a trifunctional homohexameric cytoplasmic 2225-aa 243-kDa protein associated with the first 3 enzymatic activities of the 6-step de novo pyrimidine nucleotide biosynthesis pathway: Carbamoylphosphate Synthetase (GD-CPSASE), Aspartate Carbamoyltransferase, and Dihydroorotase, containing a CPSase domain and a type-1 glutamine amidotransferase domain. PRPP is a CAD activator and UMP is an inhibitor of CPSase. CAD is directly regulated allosterically by phosphorylation from the MAPK cascade. (NCI)
C38928	FRAP1_Gene	Kinase_Family_Gene	FRAP1 Gene|FK506 Binding Protein 12-Rapamycin Associated Protein 1 Gene|FRAP|FRAP1|FRAP2|RAFT1|RAPT1	Human FRAP1 Gene (stress response PI3/PI4-Kinase Family) encodes 2549-aa 289-kDa ATP-sensor FKBP12-Rapamycin Complex Associated Protein 1, containing 8 HEAT repeats and target for the G1 cell-cycle arrest and immunosuppressive effects of FKBP12-rapamycin complex. mTOR regulates ribosome biogenesis and cell growth in response to ATP or nutrient concentrations. FRAP phosphorylation of p53 (inhibited by rapamycin) downregulates PP2A, activates BAX, and induces mitochondrial membrane permeability and caspase activation. Mitogen-induced phospholipase D-dependent phosphatidic acid interacts with the mTOR rapamycin target domain. Cellular stress inhibits MTOR activity by stabilizing MTOR-RAPTOR binding, which also promotes MTOR phosphorylation of 4EBP1 and enhances MTOR activity toward S6K1. MTOR binds UBQLN1. (NCI)
C38929	FKBP12-Rapamycin_Complex_Associated_Protein-1	Kinase	FKBP12 Rapamycin Complex Associated Protein 1|FK506 Binding Protein 12-Rapamycin Associated Protein 1|FK506 Binding Protein 12-Rapamycin Associated Protein 2|FKBP-Rapamycin Associated Protein|FRAP|FRAP1|FRAP2|RAFT1|RAPT1|Rapamycin Target Protein|mTOR	Encoded by human FRAP1 Gene (stress response PI3/PI4-Kinase Family), 2549-aa 289-kDa ATP-sensor FKBP12-Rapamycin Complex Associated Protein 1 contains 8 HEAT repeats and is a target for the G1 cell-cycle arrest and immunosuppressive effects of FKBP12-rapamycin complex. mTOR regulates ribosome biogenesis and cell growth in response to ATP or nutrient concentrations. FRAP phosphorylation of p53 (inhibited by rapamycin) downregulates PP2A, activates BAX, and induces mitochondrial membrane permeability and caspase activation. Mitogen-induced phospholipase D-dependent phosphatidic acid interacts with the mTOR rapamycin target domain. Cellular stress inhibits MTOR activity by stabilizing MTOR-RAPTOR binding, which also promotes MTOR phosphorylation of 4EBP1 and enhances MTOR activity toward S6K1. MTOR binds UBQLN1. (NCI)
C38930	ODC1_Gene	Lyase_Gene	ODC1 Gene|ODC|ODC1|Ornithine Decarboxylase 1 Gene	Transcriptional target of MYC and expressed most at G1/S and G2/M, human ODC1 Gene (Orn/Lys/Arg Decarboxylase Class-II Family) encodes 461-aa 51-kDa Ornithine Decarboxylase 1, a homodimeric rate-limiting enzyme with high turnover rate and pyridoxal phosphate cofactor that catalyzes conversion of ornithine to putrescine in the first step of the polyamine biosynthesis pathway. ODC promoter activity is influenced by cooperative E-box interactions, a cap-independent IRES in the mRNA functions at G2/M to ensure adequate polyamine levels, and enzyme activity fluctuates in response to growth-promoting stimuli. (NCI)
C38931	Ornithine_Decarboxylase-1	Lyase	Ornithine Decarboxylase 1	Expressed most at G1/S and G2/M by human ODC1 Gene (Orn/Lys/Arg Decarboxylase Class-II Family), 461-aa 51-kDa Ornithine Decarboxylase 1 is a homodimeric rate-limiting enzyme with high turnover rate and pyridoxal phosphate cofactor that catalyzes conversion of ornithine to putrescine in the first step of the polyamine biosynthesis pathway. ODC promoter activity is influenced by cooperative E-box interactions, a cap-independent IRES in the mRNA functions at G2/M to ensure adequate polyamine levels, and enzyme activity fluctuates in response to growth-promoting stimuli. (NCI)
C38932	GLIPR2_Gene	Gene_with_Unknown_or_Unclassified_Function	C9orf19 Gene|C9orf19|Chromosome 9 Open Reading Frame 19 Gene|GAPR1|GLIPR2|GLIPR2 Gene	Expressed in most tissues (2-kb mRNA highest in lung and leukocytes), 5-exon 27-kb human GLIPR2 Gene (CRISP Family) encodes 153-aa 17-kDa Golgi-Associated PR-1 Protein, which interacts with CAV1 and binds lipid-enriched Golgi membrane microdomains through myristate and ionic interactions. (NCI)
C38933	Golgi-Associated_PR-1_Protein	Protein_with_Unknown_or_Unclassified_Function	Golgi-Associated PR-1 Protein	Expressed in most tissues (highest in lung and leukocytes) by human GLIPR2 Gene (CRISP Family), 153-aa 17-kDa Golgi-Associated PR-1 Protein interacts with CAV1 and binds lipid-enriched Golgi membrane microdomains through myristate and ionic interactions. (NCI)
C38934	CD7_Gene	Immunoprotein_Gene	CD7 Gene|CD7|CD7 Antigen (p41) Gene|GP40|LEU9|TP40|TP41	Expressed in thymocytes and mature T cells, 4-exon 3.5-kb human CD7 Gene (Immunoglobulin Superfamily) encodes 240-aa 25-kDa (precursor) T-Cell Antigen CD7, a cell surface type I transmembrane glycoprotein that interacts with SECTM1, contains an Ig-like domain, and is essential in T-cell interactions and in T-cell/B-cell interaction during early lymphoid development. One of the earliest antigens on cells of the T-lymphocyte lineage, CD7 is the most reliable clinical marker of T-cell acute lymphocytic leukemia. (NCI)
C38935	T-Cell_Antigen_CD7	Immunoprotein	T-Cell Antigen CD7	Expressed in thymocytes and mature T cells by human CD7 Gene (Immunoglobulin Superfamily), 240-aa 25-kDa (precursor) T-Cell Antigen CD7 is a cell surface type I transmembrane glycoprotein that interacts with SECTM1, contains an Ig-like domain, and is essential in T-cell interactions and in T-cell/B-cell interaction during early lymphoid development. One of the earliest antigens on cells of the T-lymphocyte lineage, CD7 is the most reliable clinical marker of T-cell acute lymphocytic leukemia. (NCI)
C38936	Grade_I_Meningioma	Meningioma	Grade I Meningioma|Grade 1 Meningioma|WHO Grade I Meningioma
C38937	Grade_II_Meningioma	Meningioma	Grade II Meningioma|Grade 2 Meningioma|WHO Grade II Meningioma
C38938	Grade_III_Meningioma	Meningioma	Grade III Meningioma|Grade 3 Meningioma|WHO Grade III Meningioma
C38939	MUC1_Gene	Receptor_Gene	MUC1 Gene|CD227|EMA|MUC1|Mucin 1, Transmembrane Gene|PEM|PUM	Human mucin 1, transmembrane (MUC1) gene, located at 1q21, encodes mucin-1 protein. This gene is highly polymorphic and its allelic variants exhibit a variable number of tandem repeats. MUC1 transcribes alternatively-spliced mRNA products, resulting in different isoforms of mucin-1 protein. This gene is developmentally regulated and overexpresses mucin-1 in breast cancer.
C38940	_14q32_31	Chromosome_Band	14q32.31	A chromosome band present on 14q
C38941	_7p22_2	Chromosome_Band	7p22.2	A chromosome band present on 7p
C38942	_2p16_1	Chromosome_Band	2p16.1	A chromosome band present on 2p
C38943	_17q21_32	Chromosome_Band	17q21.32	A chromosome band present on 17q
C38944	_12q11-q13	Chromosome_Band	12q11-q13	A chromosome band present on 12q
C38945	_11q12_3	Chromosome_Band	11q12.3	A chromosome band present on 11q
C38946	PAPOLA_Gene	Polymerase_Gene	PAPOLA Gene|PAP|PAPOLA|Poly(A) Polymerase Alpha Gene	Human PAPOLA Gene (Poly A Polymerase Family) encodes phosphorylated nuclear and cytoplasmic Polynucleotide Adenylyltransferase Alpha, a possible monomeric polymerase that creates the 3 prime poly(A) tail during eukaryotic mRNA maturation. The N-terminal region is required for nonspecific polymerase activity, while the N- and C-termini are required for specific polymerase activity. Specificity may occur through C-terminus interaction with CPSF, regulated by phosphorylation/dephosphorylation. The poly(A) reaction involves endoribonucleolytic pre-RNA cleavage at the poly(A) site and synthesis of the poly(A) tail. PAPOLA is required for endoribonucleolytic cleavage at some polyadenylylation sites. (NCI)
C38947	Polynucleotide_Adenylyltransferase_Alpha	Riboadenylate_Transferase	Polynucleotide Adenylyltransferase Alpha|PAPOLA|Poly(A) Polymerase Alpha	Encoded by human PAPOLA Gene (Poly A Polymerase Family), phosphorylated nuclear and cytoplasmic Polynucleotide Adenylyltransferase Alpha is a possible monomeric polymerase that creates the 3 prime poly(A) tail during eukaryotic mRNA maturation. The N-terminal region is required for nonspecific polymerase activity, while the N- and C-termini are required for specific polymerase activity. Specificity may occur through C-terminus interaction with CPSF, regulated by phosphorylation/dephosphorylation. The poly(A) reaction involves endoribonucleolytic pre-RNA cleavage at the poly(A) site and synthesis of the poly(A) tail. PAPOLA is required for endoribonucleolytic cleavage at some polyadenylylation sites. (NCI)
C38948	PAPOLB_Gene	Polymerase_Gene	PAPOLB Gene|PAPOLB|PAPT|Poly(A) Polymerase Beta (Testis Specific) Gene|TPAP	Human PAPOLB Gene (Poly A Polymerase Family) encodes testis-specific 636-aa 72-kDa Polynucleotide Adenylyltransferase Beta, a polymerase that creates the 3 prime poly(A) tail during eukaryotic mRNA maturation. (NCI)
C38949	Polynucleotide_Adenylyltransferase_Beta	Riboadenylate_Transferase	Polynucleotide Adenylyltransferase Beta|PAPOLB|Poly(A) Polymerase Beta|Testis-Specific Poly(A) Polymerase	Encoded by human PAPOLB Gene (Poly A Polymerase Family), testis-specific 636-aa 72-kDa Polynucleotide Adenylyltransferase Beta is a polymerase that creates the 3 prime poly(A) tail during eukaryotic mRNA maturation. (NCI)
C38950	PAPOLG_Gene	Polymerase_Gene	PAPOLG Gene|PAP2|PAPOLG|Poly(A) Polymerase Gamma Gene	Human PAPOLG Gene (Poly A Polymerase Family) encodes 736-aa 83-kDa nuclear Polynucleotide Adenylyltransferase Gamma, a polymerase that catalyzes template-independent extension of the 3 prime end of an RNA strand by nonspecific and CPSF/AAUAAA-dependent polyadenylation activity. PAPOLG shares 60% amino acid identity with PAPOLA as well as similar organization of structural and functional domains. PAPOLG catalyzes post-transcriptional adenylation of several small RNAs: SRP RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. (NCI)
C38951	Polynucleotide_Adenylyltransferase_Gamma	Riboadenylate_Transferase	Polynucleotide Adenylyltransferase Gamma|Nuclear Poly(A) Polymerase Gamma|PAP Gamma|PAPOLG|Poly(A) Polymerase Gamma|SRP RNA 3-Prime Adenylating Enzyme/PAP2	Encoded by human PAPOLG Gene (Poly A Polymerase Family), 736-aa 83-kDa nuclear Polynucleotide Adenylyltransferase Gamma is a polymerase that catalyzes template-independent extension of the 3 prime end of an RNA strand by nonspecific and CPSF/AAUAAA-dependent polyadenylation activity. PAPOLG shares 60% amino acid identity with PAPOLA as well as similar organization of structural and functional domains. PAPOLG catalyzes post-transcriptional adenylation of several small RNAs: SRP RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA. (NCI)
C38952	High_Affinity_Interleukin-2_Receptor	Protein_or_Riboprotein_Complex	High Affinity Interleukin-2 Receptor|Interleukin-2 Receptor	Expressed on T- and B-cells, human heterodimeric High Affinity Interleukin-2 Receptor consists of IL2RA and IL2RB subunits, associated with a common IL2RG chain, and mediates IL2 mitogenic signaling. Homodimeric IL2RA chains constitute a low-affinity non-signaling receptor, while homodimeric IL2RB chains produce a medium-affinity signaling receptor. IL2RG comprises a signaling component of many interleukin receptors (IL2, IL4, IL7, IL9, and IL15). (NCI)
C38953	Integrin-aVBeta3	Protein_or_Riboprotein_Complex	Integrin aVBeta3|Integrin Alpha-V/Beta-3|aVBeta3|aVBeta3 Integrin	Involved in cell adhesion and signaling, human Integrin-aVBeta3 is composed of type I membrane protein chains Integrin Alpha 5 (disulfide-linked heavy and light chains) and Integrin Beta 3 that recognize RGD sequences. Multiple heterodimeric alpha/beta combinations result in different integrins. aV/beta-3 is a receptor for cytotactin, fibronectin, laminin, MMP-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin, and von Willebrand factor. (NCI)
C38954	ITGB3_Gene	Cell_Adhesion_Molecule_Gene	ITGB3 Gene|GP3A|ITGB3|Integrin, Beta 3 (Platelet Glycoprotein IIIa, Antigen CD61) Gene	Widely expressed, human ITGB3 Gene (ITGB Family) encodes type I membrane protein Integrin Beta 3, containing a VWFA-like domain and involved in cell adhesion and signaling. Multiple heterodimeric alpha/beta combinations result in different integrins. ITGB3 associates with alphaIIB or alphaV and recognize RGD; aIIB/beta-3 also recognizes HHLGGGAKQAGDV in FN gamma. Beta-3C interacts with FLNB. aV/beta-3 is a receptor for cytotactin, fibronectin, laminin, MMP-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin, and von Willebrand factor. Receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin, and vitronectin, aIIB/beta-3 binds fibrinogen to induce platelet aggregation and plug ruptured endothelia. In response to platelet aggregation, Tyr-773/785 phosphorylated ITGB3 appears to bind GRB2/SHC. ITGB3 defects cause Glanzmann thrombasthenia (GT). (NCI)
C38955	Integrin_Beta-3	Cell_Adhesion_Molecule	Integrin Beta 3|Antigen CD61|CD61|CD61 Antigen|GP3A|GPIIIa|ITGB3|Integrin Beta Chain Beta 3|Platelet Glycoprotein IIIa|Platelet Membrane Glycoprotein IIIa	Widely expressed by human ITGB3 Gene (ITGB Family), type I membrane protein Integrin Beta 3 contains a VWFA-like domain and is involved in cell adhesion and signaling. Multiple heterodimeric alpha/beta combinations result in different integrins. ITGB3 associates with alphaIIB or alphaV and recognize RGD; aIIB/beta-3 also recognizes HHLGGGAKQAGDV in FN gamma. Beta-3C interacts with FLNB. aV/beta-3 is a receptor for cytotactin, fibronectin, laminin, MMP-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin, and von Willebrand factor. Receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin, and vitronectin, aIIB/beta-3 binds fibrinogen to induce platelet aggregation and plug ruptured endothelia. In response to platelet aggregation, Tyr-773/785 phosphorylated ITGB3 appears to bind GRB2/SHC. ITGB3 defects cause Glanzmann thrombasthenia (GT). (NCI)
C38956	ITGA5_Gene	Cell_Adhesion_Molecule_Gene	ITGA5 Gene|FNRA|ITGA5|Integrin, Alpha 5 (Fibronectin Receptor, Alpha Polypeptide) Gene	Human ITGA5 Gene (ITGA Family) encodes 1049-aa 114.5-kDa (precursor) type I membrane protein Integrin Alpha 5, containing 7 FG-GAP repeats and involved in cell adhesion and signaling. Multiple heterodimeric alpha/beta combinations result in different integrins. The Alpha 5 chain undergoes post-translational cleavage of the extracellular domain to yield disulfide-linked heavy and light chains that associate with beta-1 (fibronectin and fibrinogen receptor) or beta-3 and recognize RGD. aV/beta-3 is a receptor for cytotactin, fibronectin, laminin, MMP-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin, and von Willebrand factor. Alpha-5 interacts with HPS5. (NCI)
C38958	Elongation_Factor-1	Protein_or_Riboprotein_Complex	Elongation Factor 1|E-F1|Eukaryotic Translation Elongation Factor 1	Heterotrimeric Elongation Factor 1 (containing alpha/beta/gamma or alpha/delta/gamma subunits) is responsible for delivery of aminoacyl tRNAs to the ribosome. Containing domains that bind guanine nucleotides, 80S ribosomes, and aminoacyl-tRNAs, the alpha EF-1 subunit interacts with beta/delta subunits and mediates delivery and GTP-dependent binding of aminoacyl-tRNAs to the 80S ribosome A-site. Homologous beta and delta subunits (guanine nucleotide exchange factors) stimulate GDP/GTP exchange bound to EF-1-alpha; phosphorylation affects the GDP/GTP exchange rate. The conserved gamma subunit contains an EEF1G domain and an N-terminal GST domain that may be involved in regulating EF-1 multisubunit assembly and anchorage to other cellular components. (NCI)
C38959	EEF1B1_Gene	Protein_Complex_Subunit_Gene	EEF1B1 Gene|EEF1B|EEF1B1|EF1B|Eukaryotic Translation Elongation Factor 1 Beta 1 Gene	Expressed as a 0.9-kb mRNA, human EEF1B1 Gene (EF1Beta/EF1Delta Family) encodes 224-aa 24.6-kDa Elongation Factor 1B1, a subunit of heterotrimeric Elongation Factor 1 containing alpha/beta/gamma or alpha/delta/gamma subunits. Composed of an alpha subunit nucleotide binding domain and a beta/gamma subunit nucleotide exchange complex, Elongation Factor 1 is responsible for delivery of aminoacyl tRNAs to the ribosome. The homologous guanine nucleotide exchange factor EF-1-beta and EF-1-delta subunits stimulate GDP/GTP exchange bound to EF-1-alpha; phosphorylation affects the GDP/GTP exchange rate. (NCI)
C38960	Elongation_Factor-1B1	Protein_Complex_Subunit	Elongation Factor 1B1|EEF1B1|EF-1-Beta1|Elongation Factor-1-Beta1|Eukaryotic Translation Elongation Factor 1 Beta 1	Encoded by human EEF1B1 Gene (EF1Beta/EF1Delta Family), 224-aa 24.6-kDa Elongation Factor 1B1 is a subunit of heterotrimeric Elongation Factor 1 (containing alpha/beta/gamma or alpha/delta/gamma subunits). Composed of an alpha subunit nucleotide binding domain and a beta/gamma subunit nucleotide exchange complex, Elongation Factor 1 is responsible for delivery of aminoacyl tRNAs to the ribosome. The homologous guanine nucleotide exchange factor EF-1-beta and EF-1-delta subunits stimulate GDP/GTP exchange bound to EF-1-alpha; phosphorylation affects the GDP/GTP exchange rate. (NCI)
C38961	EEF1B2_Gene	Protein_Complex_Subunit_Gene	EEF1B2 Gene|EEF1B|EF1B|Eukaryotic Translation Elongation Factor 1 Beta 2 Gene	Human EEF1B2 Gene (EF1Beta/EF1Delta Family) encodes Elongation Factor 1B2, a subunit of heterotrimeric Elongation Factor 1 containing alpha/beta/gamma or alpha/delta/gamma subunits. Composed of an alpha subunit nucleotide binding domain and a beta/gamma subunit nucleotide exchange complex, Elongation Factor 1 is responsible for delivery of aminoacyl tRNAs to the ribosome. The homologous guanine nucleotide exchange factor EF-1-beta and EF-1-delta subunits stimulate GDP/GTP exchange bound to EF-1-alpha; phosphorylation affects the GDP/GTP exchange rate. (NCI)
C38962	Elongation_Factor-1B2	Protein_Complex_Subunit	Elongation Factor 1B2|EEF1B2|EF-1-Beta2|Elongation Factor-1-Beta2|Eukaryotic Translation Elongation Factor 1 Beta 2	Encoded by human EEF1B2 Gene (EF1Beta/EF1Delta Family), Elongation Factor 1B2 is a subunit of heterotrimeric Elongation Factor 1 (containing alpha/beta/gamma or alpha/delta/gamma subunits). Composed of an alpha subunit nucleotide binding domain and a beta/gamma subunit nucleotide exchange complex, Elongation Factor 1 is responsible for delivery of aminoacyl tRNAs to the ribosome. The homologous guanine nucleotide exchange factor EF-1-beta and EF-1-delta subunits stimulate GDP/GTP exchange bound to EF-1-alpha; phosphorylation affects the GDP/GTP exchange rate. (NCI)
C38963	EEF1D_Gene	Protein_Complex_Subunit_Gene	EEF1D Gene|EEF1D|EF1D|Eukaryotic Translation Elongation Factor 1 Delta (Guanine Nucleotide Exchange Protein) Gene	Human EEF1D Gene (EF1Beta/EF1Delta Family) encodes 281-aa 31-kDa Elongation Factor 1D, a subunit of heterotrimeric Elongation Factor 1 containing alpha/beta/gamma or alpha/delta/gamma subunits. Composed of an alpha subunit nucleotide binding domain and a beta/gamma subunit nucleotide exchange complex, Elongation Factor 1 is responsible for delivery of aminoacyl tRNAs to the ribosome. The homologous guanine nucleotide exchange factor EF-1-delta and EF-1-beta subunits stimulate GDP/GTP exchange bound to EF-1-alpha; phosphorylation affects the GDP/GTP exchange rate. EEF1D may interact with HIV-1 Tat and repress host-cell mRNA translation. (NCI)
C38964	Elongation_Factor-1D	Protein_Complex_Subunit	Elongation Factor 1D|Antigen NY-CO-4|EEF1D|EF-1-Delta|Elongation Factor-1-Delta|Eukaryotic Translation Elongation Factor 1 Delta|Guanine Nucleotide Exchange Protein	Encoded by human EEF1D Gene (EF1Beta/EF1Delta Family), 281-aa 31-kDa Elongation Factor 1D is a subunit of heterotrimeric Elongation Factor 1 (containing alpha/beta/gamma or alpha/delta/gamma subunits). Composed of an alpha subunit nucleotide binding domain and a beta/gamma subunit nucleotide exchange complex, Elongation Factor 1 is responsible for delivery of aminoacyl tRNAs to the ribosome. The homologous guanine nucleotide exchange factor EF-1-delta and EF-1-beta subunits stimulate GDP/GTP exchange bound to EF-1-alpha; phosphorylation affects the GDP/GTP exchange rate. EEF1D may interact with HIV-1 Tat and repress host-cell mRNA translation. (NCI)
C38965	EEF1G_Gene	Protein_Complex_Subunit_Gene	EEF1G Gene|EEF1G|EF1G|Eukaryotic Translation Elongation Factor 1 Gamma Gene	Human EEF1G Gene encodes 437-aa 50-kDa conserved Elongation Factor 1G, containing an EEF1G domain and an N-terminal GST domain that may be involved in regulating assembly of multisubunit EF-1 and aminoacyl-tRNA synthetase complexes. EEF1G is a subunit of heterotrimeric Elongation Factor 1 (containing alpha/beta/gamma or alpha/delta/gamma subunits). Composed of an alpha subunit nucleotide binding domain and a beta/gamma subunit nucleotide exchange complex, Elongation Factor 1 is responsible for delivery of aminoacyl tRNAs to the ribosome. EEF1G may anchor complexes to other cellular components. (NCI)
C38966	Elongation_Factor-1G	Protein_Complex_Subunit	Elongation Factor 1G|EEF1G|EF-1-Gamma|Elongation Factor-1-Gamma|Eukaryotic Translation Elongation Factor 1 Gamma|PRO1608|Pancreatic Tumor-Related Protein|Translation Elongation Factor EEF-1 Gamma Chain|eEF-1B Gamma	Encoded by human EEF1G Gene, 437-aa 50-kDa conserved Elongation Factor 1G contains an EEF1G domain and an N-terminal GST domain that may be involved in regulating assembly of multisubunit EF-1 and aminoacyl-tRNA synthetase complexes. EEF1G is a subunit of heterotrimeric Elongation Factor 1 (containing alpha/beta/gamma or alpha/delta/gamma subunits). Composed of an alpha subunit nucleotide binding domain and a beta/gamma subunit nucleotide exchange complex, Elongation Factor 1 is responsible for delivery of aminoacyl tRNAs to the ribosome. EEF1G may anchor complexes to other cellular components. (NCI)
C38967	Mucin-1	Cell_Surface_Receptor	Mucin 1|Breast Carcinoma-Associated Antigen DF3|CD227|CD227 Antigen|Carcinoma-Associated Mucin|DF3 Antigen|EMA|Episialin|Epithelial Membrane Antigen|H23 Antigen|H23AG|MUC1|Mucin|PEM|PEMT|PUM|Peanut-Reactive Urinary Mucin|Polymorphic Epithelial Mucin|Transmembrane Mucin 1|Tumor-Associated Epithelial Membrane Antigen|Tumor-Associated Mucin	Expressed as alternative isoforms in some hematopoietic cells and most glandular and ductal epithelial cells by human MUC1 Gene, highly glycosylated Mucin-1 is a type I membrane protein (major form) containing a large extracellular tandem repeat domain and a SEA domain. The number of repeats is highly polymorphic. MUC1 may protect epithelial surfaces, play a role in adhesion, cell-cell interactions, signaling, and metastasis. MUC1 may interact directly or indirectly with the actin cytoskeleton. Isoforms 5 and 9 are secreted. Isoform 7 behaves as a receptor and binds isoform 5; binding induces phosphorylation of isoform 7, alters cell morphology, and initiates cell signaling. MUC1 can bind to GRB2. Cleaved isoform 1 forms a heterodimer with its secreted C-terminal peptide. Isoforms 1 and 7 are transphosphorylated on serine and tyrosine residues.
C38969	Angiotensin-converting_Enzyme_2_Pathway	Other_Biochemical_Pathway	Angiotensin-converting Enzyme 2 Pathway|Angiotensin-converting enzyme 2 regulates heart function
C38970	Acetaminophen_Pathway	Other_Biochemical_Pathway	Acetaminophen Pathway|Mechanism of Acetaminophen Activity and Toxicity
C38971	Regulation_of_Apoptosis_Pathway	Apoptosis_Regulation_Pathway	Regulation of Apoptosis Pathway|Role of nicotinic acetylcholine receptors in the regulation of apoptosis
C38972	AHR_Signal_Transduction_Pathway	Signaling_Pathways	AHR Signal Transduction Pathway|Ahr Signal Transduction Pathway	The Ah receptor, bHLH/PAS transcription factor, upon binding of an agonist such as 2,3,7,8-tetrachlorodibenzo-p-dioxin translocates into the nucleus and heterodimerizes with the transcription factor ARNT. The Ahreceptor/ARNT heterodimer binds to dioxin-responsive elements and alters expression of a number of genes including; CYP1A1, CYP1A2, CYP1B1, and NAD(P)H quinone oxidoreductase. The inactive form of the Ah receptor exists in the cytoplasm as a tetrameric complex composed of the ligand binding subunit, a dimer of the 90-kDa heat shock protein, and X-associated protein 2 (also refered to as AIP or ARA9). (BioCarta)
C38973	Actin_Branching_Pathway	Cell_Motility_Pathway	Actin Branching Pathway|Y branching of actin filaments
C38974	Attenuation_of_GPCR_Signaling_Pathway	Signaling_Pathways	Attenuation of GPCR Signaling Pathway|Attenuation of GPCR Signaling
C38975	Agrin_Pathway	Cell_Differentiation_or_Development_Pathway	Agrin Pathway|Agrin in Postsynaptic Differentiation	The heparan sulphate proteoglycan agrin is well known as the key assembly factor of postsynaptic differentiation at the neuromuscular junction (NMJ), but recent data suggest it also plays a direct role in the organization of the cytoskeleton in the skeletal muscle.  Signaling through muscle-specific proteins such as muscle specific kinase (MuSK) and or acetylcholine receptor (AchRs)/rapsyn, agrin can activate ubiquitously expressed Rac, Cdc42, and p21-activated kinase (PAK) that are involved in actin polymerization.  Agrin also engages signaling pathways of several potent oncogenes (i.e., SFK, ErbB receptors, and cortactin). (BioCarta)
C38976	Hemoglobin_Chaperone_Pathway	Other_Biochemical_Pathway	Hemoglobin Chaperone Pathway|Hemoglobin's Chaperone
C38977	AIF_Pathway	Apoptosis_Regulation_Pathway	AIF Pathway|Opposing roles of AIF in Apoptosis and Cell Survival
C38978	Stress_Fiber_Formation_Pathway	Other_Biochemical_Pathway	Stress Fiber Formation Pathway|Rho-Selective Guanine Exchange Factor AKAP13 Mediates Stress Fiber Formation
C38979	AKAP8_in_Mitosis_Pathway	Cell_Cycle_Regulation_Pathway	AKAP8 in Mitosis Pathway|AKAP95 role in mitosis and chromosome dynamics
C38980	Centrosome_Pathway	Other_Biochemical_Pathway	Centrosome Pathway|Protein Kinase A at the Centrosome
C38981	AKT_Signaling_Pathway	Signaling_Pathways	AKT Signaling Pathway	Many cell-surface receptors induce production of second messengers like PIP3, phosphatidylinositol 3,4,5-trisphosphate, that convey signals to the cytoplasm from the cell surface. PIP3 signals activate the kinase PDK1, 3-phosphoinositide-dependent protein kinase-1, which in turn activates the kinase AKT, also known as protein kinase B. Proteins phosphorylated by activated AKT promote cell survival. Phosphorylation of Ikappa-B kinase leads to activation of the transcription factor NF-kB to oppose apoptosis. Bad is a protein in the Bcl-2 gene family that opposes Bcl-2 to induce apoptosis. Phosphorylation of Bad by AKT blocks anti-apoptotic activity to promote cell survival. Similarly, phosphorylation of the protease caspase 9 or forkhead transcription factors by AKT block the induction of apoptosis by these factors. AKT promotes cell survival and opposes apoptosis by a variety of routes. (BioCarta)
C38982	ALK_Pathway	Cell_Differentiation_or_Development_Pathway	ALK Pathway|ALK in cardiac myocytes
C38983	Alternative_Complement_Pathway	Immune_Response_Regulation_Pathway	Alternative Complement Pathway
C38984	Glycosylation_of_N-linked_Oligosaccarides_Pathway	Other_Biochemical_Pathway	Glycosylation of N-linked Oligosaccarides Pathway|Steps in the Glycosylation of Mammalian N-linked Oligosaccarides	The biosynthesis pathway of N-glycans is a costly system with respect to the number of enzymes that are involved in the synthesis and trimming of N-glycans. While the structural diversity of N-glycans in mature proteins in the cell surface is introduced by glycosyltransferases in the Golgi complex, the core glycans in the ER are universal from yeast to mammal and have been considered as intermediates. (BioCarta)
C38985	Acute_Myocardial_Infarction_Pathway	Disease_Pathway	Acute Myocardial Infarction Pathway|Acute Myocardial Infarction
C38986	Anthrax_Toxin_Pathway	Infectious_Disease_Pathway	Anthrax Toxin Pathway|Anthrax Toxin Mechanism of Action
C38987	RNA_Interference_Pathway	Regulatory_Pathways	RNA Interference Pathway|RNA polymerase III transcription	About 8% of human genes have been estimated to carry out transcription from both DNA strands, resulting in significant level of endogenous antisense RNA.  In the cytoplasm the antisense RNA leads to formation of long dsRNA, which activates the interferon and RNA-dependent protein kinase antiviral pathway.  Most endogenous antisense RNA is made in the nucleus and two responses have been suggested for the nuclear dsRNA.  First, the dsRNA may be processed by enzymes of the family of adenosine deaminases that act on RNA (ADAR).  The deaminated dsRNAs contain various levels of inosines.  dsRNA containing high level of inosines are tightly bound by a protein complex that results in their nuclear retention.  dsRNA containing low level of inosines may be able to exit the nucleus.  Second, the nuclear dsRNA can lead to gene silencing and heterochromatin formation. (BioCarta)
C38988	Amyloid_Beta-Peptide_Pathway	Neurodegenerative_Disorders_Pathway	Amyloid Beta-Peptide Pathway|Generation of amyloid b-peptide by PS1
C38989	ADP-Ribosylation_Pathway	Other_Biochemical_Pathway	ADP-Ribosylation Pathway|ADP-Ribosylation Factor
C38990	Oxidative_Stress_Pathway	Regulatory_Pathways	Oxidative Stress Pathway|Oxidative Stress Induced Gene Expression Via Nrf2
C38991	GM-CSF_Receptor	Protein_or_Riboprotein_Complex	GM-CSF Receptor|CSF2RA/CSF2RB Complex|CSF2RA/CSF2RB Receptor	Heterodimeric human GM-CSF Receptor is composed of Colony Stimulating Factor 2 Receptor Alpha Chain and Colony Stimulating Factor 2 Receptor Beta Chain. CSF2RA is a type I membrane protein with a box 1 motif for JAK interaction/activation and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. The receptor signal transducing beta chain is common to the high affinity IL3-, IL5- and GM-CSF receptors. CSF2R transduces the CSF2 signal for proliferation, differentiation, and activation of (primarily) granulocyte and macrophage hematopoietic cells. (NCI)
C38992	Ribosomal_Biogenesis_Pathway	Metabolic_Pathways	Ribosomal Biogenesis Pathway|Tumor Suppressor Arf Inhibits Ribosomal Biogenesis
C38993	Arginine_Histidine_Glutamate_Glutamine_and_Proline_Degradation_Pathway	Degradation_Pathway	Arginine, Histidine, Glutamate, Glutamine, and Proline Degradation Pathway|Catabolic Pathways for Arginine , Histidine, Glutamate, Glutamine, and Proline	Glutamine is converted to glutamate by glutaminase, or several other enzymes, by the removal of the amide nitrogen.  Proline is first converted to a Schiff base and then converted by hydrolysis to glutamate-5-semialdehyde.  All of these changes occur on the same carbon.  Arginine and histidine contain 5 adjacent carbons and a sixth carbon attached through a nitrogen atom.  The catabolism of these amino acids is thus slightly more complicated than glutamine or proline.  Arginine is converted to ornithine and urea.  Ornithine is further transaminated to produce glutamate-5-semialdehyde.  Glutamate-5-semialdehyde is converted to glutamate.  Tetrahydrofolate is the cofactor in the final step converting histidine to glutamate.  Transamination or deamination of glutamate produces a-ketoglutarate which feeds into the citric acid cycle. (BioCarta)
C38994	Antigen_Dependent_B_Cell_Activation_Pathway	Immune_Response_Regulation_Pathway	Antigen Dependent B Cell Activation Pathway|Antigen Dependent B Cell Activation
C38995	Angiotensin_II_Signaling_Pathway	Signaling_Pathways	Angiotensin II Signaling Pathway|Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling	Ang II binding to AT1-R triggers the activation of Ca2+ signaling and PKC. The signal is then transmitted to Pyk2 and to the small G protein Rac1 but not Cdc42.  In turn, Rac1 activates a small G protein-activated kinase whose identity is still controversial, but which has been suggested to be PAK1.  Finally, the JNK cascade, including MEKK1, SEK1, and JNK, is activated, causing induction of the c-Jun gene via binding of ATF2 and c-Jun heterodimer to the junTRE2 site.  Ang II is closely involved in cardiac remodeling by stimulating synthesis of extracellular matrix proteins.  It was recently found that expression of fibronectin by Ang II is transcriptionally regulated by AP-1 complex in cardiac fibroblasts.  The collagenase gene, containing AP-1 sites, is also regulated by AP-1 components, including c-Jun.  AP-1 activity is also enhanced in Ang II-induced cardiac hypertrophy.  Expression of ANF is regulated by AP-1 components. (Biocarta)
C38996	ATM_Signaling_Pathway	DNA_Repair_Pathway|Signaling_Pathways	ATM Signaling Pathway	The ataxia telangiectasia-mutated gene (ATM) encodes a protein kinase that acts as a tumor suppressor. ATM activation by ionizing radiation damage to DNA stimulates DNA repair and blocks progression through the cell cycle. Mutation of the ATM gene causes the disease ataxia telangiectasia which involves an inherited predisposition to some cancers. To play this role ATM interacts with a broad network of proteins, including checkpoint factors (chk1, chk2), tumor suppressors (p53 and BRCA), DNA repair factors (RAD50, RAD51, GADD45), and other signaling molecules (c-Abl and NF-kB). In addition to regulating DNA repair and the cell cycle, ATM can also trigger apoptosis in radiation treated cells. (Biocarta)
C38997	Cancer_Susceptibility_Pathway	Disease_Pathway	Cancer Susceptibility Pathway|Role of BRCA1, BRCA2 and ATR in Cancer Susceptibility
C38998	BAD_Regulation_Pathway	Regulatory_Pathways	BAD Regulation Pathway|Regulation of BAD phosphorylation	The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112, 136, and 155). Phosphorylation at these sites results in loss of the ability of BAD to heterodimerize with the survival proteins BCL-XL or BCL-2. Phosphorylated BAD binds to 14-3-3 and is sequestered in the cytoplasm. While ser-136 phosphorylation is concordant with the activation of Akt, Ser-112 phosphorylation requires activation of the Ras-MAPK pathway. BAD Ser 155 was found to be a major site of phosphorylation induced following stimulation by growth factors and prevented by protein kinase A inhibitors. (Biocarta)
C38999	BARD1_Pathway	DNA_Repair_Pathway	BARD1 Pathway|BRCA1-dependent Ub-ligase activity	BRCA1 is a breast and ovarian cancer tumor suppressor protein that associates with BARD1 to form a RING/RING heterodimer. The BRCA1/BARD1 RING complex functions as an ubiquitin (Ub) ligase with activity substantially greater than individual BRCA1 or BARD1 subunits. The BRCA1 tumor suppressor forms a heterodimer with the BARD1 protein, and the resulting complex functions as an E3 ubiquitin ligase that catalyzes the synthesis of polyubiquitin chains. UbcH5c and UbcH7 also interact with the BRCA1/BARD1 complex with similar affinity (not shown on this figure). Although the in vivo substrate(s) is not yet known, BRCA1 has been observed to undergo autoubiquitination and is capable of monoubiquitinating histones 2A and 2AX in vitro. (Biocarta)
C39000	GPCR_Desensitization_Pathway	Regulatory_Pathways	GPCR Desensitization Pathway|beta-arrestins in GPCR Desensitization
C39001	GPCR_Signaling_Pathway	Signaling_Pathways	GPCR Signaling Pathway|Roles of beta-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling	The binding of b-arrestins to agonist-occupied GPCRs coincides with the recruitment of Src family tyrosine kinases, including c-Src, Hck and c-Fgr (Src-TK), to the receptor-b-arrestin complex. Several signaling events have been reported to involve b-arrestin-dependent Src recruitment. These include the regulation of clathrin-dependent beta2-adrenergic receptor endocytosis by tyrosine phosphorylation of dynamin, Ras-dependent activation of the ERK1/2 MAP kinase cascade and stimulation of cell proliferation by beta2-adrenergic and neurokinin NK1 receptors, and stimulation of chemokine CXCR1 receptor-mediated neutrophil degranulation. (Biocarta)
C39002	MAP_Kinase_Activation_Pathway	Protein_Activation_Pathway	MAP Kinase Activation Pathway|Role of beta-arrestins in the activation and targeting of MAP kinases
C39003	Bystander_B_Cell_Activation_Pathway	Immune_Response_Regulation_Pathway	Bystander B Cell Activation Pathway|Bystander B Cell Activation	Expression of Fas-Ligand by T cells can induce apoptosis through interaction with Fas on the target cell. A target of Fas-mediated apoptosis is the B cell. B cells that are not activated by antigen, bystander B cells, can interact through CD40 with the CD40 ligand on T cells. The CD40-CD40L interaction induces Fas expression by bystander B cells, and the interaction of Fas with the T cell Fas-Ligand, followed by B cell apoptosis. B cells that are activated by antigen binding and that interact with the T cell receptor through the B cell MHC II appear to become resistant to Fas-mediated apoptosis, survive and proliferate. IL-4 also appears to confer B cell resistance to Fas-mediated apoptosis. The induction of apoptosis in non-antigen stimulated B cells may prevent B cells from proliferating inappropriately and failure of this mechanism may be involved in autoimmune disorders and B cell lymphomas. (Biocarta)
C39004	B-Cell_Survival_Pathway	Immune_Response_Regulation_Pathway	B-Cell Survival Pathway|B Cell Survival Pathway	Physical interactions between integrin alpha4beta1 heterodimer expressed on B cells and counter receptors on stroma cells are key mediators of the survival of normal and malignant B cells. Recent data indicate that integrin stimulation increases FBI-1, XIAP, survivin, and CCT4 expression but inhibits Requiem, c-Fos, and caspase 3 and 7 induction. (Biocarta)
C39005	BCR_Signaling_Pathway	Signaling_Pathways	BCR Signaling Pathway
C39006	Bioactive_Peptide_Signaling_Pathway	Signaling_Pathways	Bioactive Peptide Signaling Pathway|Bioactive Peptide Induced Signaling Pathway
C39007	Botulin_Pathway	Infectious_Disease_Pathway	Botulin Pathway|Blockade of Neurotransmitter Relase by Botulinum Toxin
C39008	BTG_Cell_Cycle_Regulation_Pathway	Cell_Cycle_Regulation_Pathway	BTG Cell Cycle Regulation Pathway|BTG family proteins and cell cycle regulation
C39009	Calmodulin_Pathway	Regulatory_Pathways	Calmodulin Pathway|Ca++/ Calmodulin-dependent Protein Kinase Activation
C39010	Calcineurin_Pathway	Cell_Differentiation_or_Development_Pathway	Calcineurin Pathway|Effects of calcineurin in Keratinocyte Differentiation
C39011	Cardiac_Hypertrophy_Pathway	Disease_Pathway	Cardiac Hypertrophy Pathway|Role of EGF Receptor Transactivation by GPCRs in Cardiac Hypertrophy
C39012	CARM1_Transcription_Regulation_Pathway	Regulatory_Pathways	CARM1 Transcription Regulation Pathway|Transcription Regulation by Methyltransferase of CARM1
C39013	Estrogen_Receptor_Regulation_by_CARM1_Pathway	Regulatory_Pathways	Estrogen Receptor Regulation by CARM1 Pathway|CARM1 and Regulation of the Estrogen Receptor
C39014	Caspase_Cascade_Pathway	Apoptosis_Regulation_Pathway	Caspase Cascade Pathway|Caspase Cascade in Apoptosis
C39015	Anandamide_Metabolism_Pathway	Metabolic_Pathways	Anandamide Metabolism Pathway|Metabolism of Anandamide, an Endogenous Cannabinoid
C39016	EGF_Receptor_Downregulation_by_CBL_Pathway	Regulatory_Pathways	EGF Receptor Downregulation by CBL Pathway|CBL mediated ligand-induced downregulation of EGF receptors
C39017	CCR3_Signaling_Pathway	Signaling_Pathways	CCR3 Signaling Pathway|CCR3 signaling in Eosinophils
C39018	CCR5_Signaling_Pathway	Signaling_Pathways	CCR5 Signaling Pathway|Pertussis toxin-insensitive CCR5 Signaling in Macrophage	The chemokine receptors CCR5 and CXCR4 in macrophages are activated by their peptide ligands and also by the HIV envelope protein GP120 during HIV infection.  One mechanism of signaling by these GPCRs is through activation of Gi signaling.  These chemokine receptors can also signal through a Gi-independent pertussis toxin-insensitive pathway.  This pathway elevates calcium influx into the cell through CRAC channels, ion channels that are activated by calcium release.  Elevated calcium from CRAC is required for downstream activation of Pyk2, a focal adhesion-associated protein kinase.  Non Gi signaling by these chemokine receptors also involves the Jnk and p38 Map kinase pathways leading to AP-1 activation and activation of genes such as MIP-1 and MCP-1.  This pathway may be involved in the role of macrophages in the pathogenesis of AIDS. (BioCarta)
C39019	CD40L_Signaling_Pathway	Signaling_Pathways	CD40L Signaling Pathway	The CD40 receptor was first associated with expression in B cells and the role it plays through its ligand CD40L (CD154) in moderating T cell activation. Broader expression may indicate a broader role for CD40 and CD40L in immune function and disease states such as transplant rejection and HIV infection. Disruption and modulation of CD40 interaction with CD40L may prove therapeutic in the treatment of autoimmune disorders, heart disease, and cancer. As a member of the TNF receptor family, CD40 relies on interaction with TRAF proteins to mediate an intracellular signal in response to CD40L binding. The pathway downstream of TRAFs activates the transcription factor NF-kappaB through a kinase pathway involving map kinases, NIK (NF-kappaB inducing kinase) and I-kappa B kinases. Some CD40 responses like regulation of immunoglobulin expression might be mediated by NF-kappaB transcriptional activation. (BioCarta)
C39020	CDC25_and_CHK1_Regulatory_Pathway	Regulatory_Pathways	CDC25 and CHK1 Regulatory Pathway|cdc25 and chk1 Regulatory Pathway in response to DNA damage	Cdc25 is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into the M-phase of the cell cycle. Cdc25 is phosphorylated throughout interphase but not in mitosis. The primary site for phosphorylation of cdc25 is Ser216. Phosphorylated cdc25 binds to members of the 14-3-3 family of proteins which prevents its activation of cdc2. Chk1, a protein kinase involved in the DNA damage checkpoint response in fission yeast, has been shown to phosphorylate cdc25 at Ser216 in vitro. (BioCarta)
C39021	Cell_Migration_Pathway	Cell_Motility_Pathway	Cell Migration Pathway|Role of PI3K subunit p85 in regulation of Actin Organization and Cell Migration
C39022	MAP_Kinase_Downregulation_Pathway	Regulatory_Pathways	MAP Kinase Downregulation Pathway|Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway
C39023	Cadmium_Induction_Pathway	Regulatory_Pathways	Cadmium Induction Pathway|Cadmium induces DNA synthesis and proliferation in macrophages
C39024	Cell_to_Cell_Adhesion_Signaling_Pathway	Signaling_Pathways	Cell to Cell Adhesion Signaling Pathway|Cell to Cell Adhesion Signaling
C39025	Cyclin_Regulation_of_Cell_Cycle_Pathway	Cell_Cycle_Regulation_Pathway	Cyclin Regulation of Cell Cycle Pathway|Cyclins and Cell Cycle Regulation	The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted fashion to drive the stages of the cell cycle. Cyclins combine with cyclin dependent kinases (cdks) to form activated kinases that phosphorylate targets leading to cell cycle regulation. A breakdown in the regulation of this cycle can lead to out of control growth and contribute to tumor formation. Defects in many of the molecules that regulate the cell cycle have been implicated in cancer. Key among these are p53, the cdk inhibitors (p15, p16, p18, p19, p21, p27), and Rb, all of which act to keep the cell cycle from progressing until all repairs to damaged DNA have been completed. (BioCarta)
C39026	Ceramide_Signaling_Pathway	Signaling_Pathways	Ceramide Signaling Pathway
C39027	CFTR_Pathway	Regulatory_Pathways	CFTR Pathway|Cystic fibrosis transmembrane conductance regulator (CFTR) and beta 2 adrenergic receptor (b2AR) pathway	The defects in cAMP-regulated chloride channel CTFR are believed to be the major cause for cystic fibrosis. Regulation of CFTR protein by the surface receptor beta adrenergic receptor is mediated through the ezrin/radixin/moesin binding phosphoprotein 50 (EBP50), which binds both the C-termini CFTR and b2AR through their PDZ binding motifs.  In the resting state, CFTR, b2AR, and EBP50 exist as a macromolecular complex on the apical surface of epithelial cells.  Upon agonist activation of the b2AR, the adenylate cyclase is stimulated through the G protein pathway, leading to an increase in cAMP. The elevated concentration of cAMP activates PKA, which is anchored near CFTR via interaction with Ezrin. The phosphorylation of CFTR by PKA disrupts the complex and leads to compartmentalized and specific signaling of the channel. (BioCarta)
C39028	Apoptosis_DNA_Damage_Pathway	Apoptosis_Regulation_Pathway	Apoptosis DNA Damage Pathway|Apoptotic Signaling in Response to DNA Damage	The cellular activation of the caspase cascade resulting in cell death is triggered by chemical damage to DNA which stimulates a sequence resulting in the cleavage of BID or directly initiates the permeability transition of the mitochondrial membrane. The permeability transition releases several factors including cytochrome c, AIF and other factors in to the cytoplasm. Cytochrome c, a key protein in electron transport, is released from mitochondria in response to apoptotic signals, and activates Apaf-1, a protease released from mitochondria. Activated Apaf-1 activates caspase-9 and the rest of the caspase cascade. The caspases are a class of cysteine proteases that includes several representatives involved in apoptosis. The caspases convey the apoptotic signal in a proteolytic cascade, with caspases cleaving and activating other caspases that then degrade other cellular targets that lead to cell death. (BioCarta)
C39029	ChREBP_Pathway	Regulatory_Pathways	ChREBP Pathway|ChREBP regulation by carbohydrates and cAMP
C39030	BioCarta_Circadian_Rhythm_Pathway	Other_Biochemical_Pathway	Circadian Rhythm Pathway 2|Circadian Rhythms
C39031	CK1_CDK5_Regulation_Pathway	Regulatory_Pathways	CK1/CDK5 Regulation Pathway|Regulation of ck1/cdk5 by type 1 glutamate receptors
C39032	Classical_Complement_Pathway	Immune_Response_Regulation_Pathway	Classical Complement Pathway
C39033	Complement_Pathway	Immune_Response_Regulation_Pathway	Complement Pathway
C39034	Polyadenylation_Pathway	Other_Biochemical_Pathway	Polyadenylation Pathway|Polyadenylation of mRNA	Gene expression requires the coordination and integration of multiple processes, including transcription, splicing, polyadenylation, nucleocytoplasmic export, and translation of mRNAs. Posttranscriptional addition of poly (A) to the 3' end of mRNA is an important process conserved from bacteria to humans. In eukaryotes, polyadenylation is essential for the stability of many mRNAs and also influences the efficiency of translation. Most histone-mRNAs and all snRNAs (except U6), however are not polyadenylated. The mature mRNA moves to the nuclear surface and is exported through nuclear pores. (BioCarta)
C39035	Mitochondrial_Carnitine_Palmitoyltransferase_Pathway	Metabolic_Pathways	Mitochondrial Carnitine Palmitoyltransferase Pathway|Mitochondrial Carnitine Palmitoyltransferase (CPT) System
C39036	CREB_Activation_Signaling_Pathway	Signaling_Pathways	CREB Activation Signaling Pathway|Transcription factor CREB and its extracellular signals	The transcription factor CREB binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Protein kinase A and the calmodulin-dependent protein kinases CaMKII stimulate CREB phosphorylation at Ser133, a key regulatory site controlling transcriptional activity. Growth and neurotrophic factors also stimulate CREB phosphorylation at Ser133. Phosphorylation occurs at Ser133 via p44/42 MAP Kinase and p90RSK and also via p38 MAP Kinase and MSK1. CREB mutants exhibit deficiencies in spatial learning tasks, while flies overexpressing or lacking CREB show enhanced or diminished learning, respectively. (BioCarta)
C39037	Spermatogenesis_Regulation_Pathway	Regulatory_Pathways	Spermatogenesis Regulation Pathway|Regulation of Spermatogenesis by CREM
C39038	CSK_Protein_Kinase_Activation_Pathway	Immune_Response_Regulation_Pathway	CSK Protein Kinase Activation Pathway|Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor
C39039	Sumoylation_in_Modulation_of_CtBP-Dependent_Gene_Response_Pathway	Other_Biochemical_Pathway	Sumoylation in Modulation of CtBP-Dependent Gene Response Pathway|SUMOylation as a mechanism to modulate CtBP-dependent gene responses
C39040	CTCF_Pathway	Regulatory_Pathways	CTCF Pathway|CTCF: First Multivalent Nuclear Factor	CTCF is central to signaling pathways in immature B cells elicited by cross-linking the Ig BCR and stimulation with TGF. Both stimuli result in induction of cell cycle arrest and apoptosis. BCR ligation stimulates a transient induction of MYC that leads to high level CTCF expression and feedback suppression of MYC transcription. BCR ligation also activates PTEN opposing PI3K activation of MYC. Pharmacologic inactivation of PI3K or mTOR/FRAP results in suppression of S6K resulting in activation of CTCF and suppression of MYC. CTCF activation induces transcriptional activation of p19ARF, with its downstream consequences, and of p27. Growth arrest is occasioned by co-expression of p21 and p27 and inhibition of MYC. CTCF, is a multivalent DNA-sequence binder whose specificity is mediated by different sets of zinc finger (ZF) proteins. (BioCarta)
C39041	T-Cell_Activation_Co-Stimulatory_Signaling_Pathway	Immune_Response_Regulation_Pathway|Signaling_Pathways	T-Cell Activation Co-Stimulatory Signaling Pathway|The Co-Stimulatory Signal During T-cell Activation
C39042	CTL-mediated_Immune_Response_Pathway	Immune_Response_Regulation_Pathway	CTL-mediated Immune Response Pathway|CTL mediated immune response against target cells
C39043	CXCR4_Signaling_Pathway	Signaling_Pathways	CXCR4 Signaling Pathway
C39044	Cytokine_Network_Pathway	Immune_Response_Regulation_Pathway	Cytokine Network Pathway|Cytokine Network
C39045	D4-GDI_Signaling_Pathway	Signaling_Pathways	D4-GDI Signaling Pathway	D4-GDP dissociation inhibitor (D4-GDI) is a negative regulator of the ras related Rho Family of GTPases. Since the rho GTPases promote cytoskeletal and membrane changes associated with apoptotic cell death, the removal of the D4-GDI block through its cleavage is important for inducing apoptosis. Caspase-3 cleaves the 28 kDa mature form of D4-GDI to give a 5 kDa and 23 kDa size fragment. The 23 kDa fragment then translocates to the nucleus. The mechanisms involving cleavage of D4-GDI with apoptosis are not presently known. Activation of the Jun N-Terminal kinase, a regulator of apoptosis, may be one of the mechanisms. (BioCarta)
C39046	DBPB_Transcriptional_Activation_Pathway	Regulatory_Pathways	DBPB Transcriptional Activation Pathway|Transcriptional activation of dbpb from mRNA
C39047	CSF2RA_Gene	Cytokine_Receptor_Gene	CSF2RA Gene|CD116|CDw116|CSF2R|CSF2RA|CSF2RAX|CSF2RX|Colony Stimulating Factor 2 Receptor, Alpha, Low-Affinity (Granulocyte-Macrophage) Gene|GMCSFR|GMR	Expressed as 6 transcripts for five alternative membrane-bound and soluble isoforms (3, 4, and 6), human CSF2RA Gene (Type I Cytokine Receptor 5 Family) encodes Colony Stimulating Factor 2 Receptor Alpha Chain, a type I membrane protein with a box 1 motif for JAK interaction/activation; a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding; and the alpha subunit of a heterodimeric low affinity receptor for granulocyte-macrophage colony-stimulating factor. The receptor signal transducing beta chain is common to the IL3-, IL5- and GM-CSF receptors. CSF2R transduces the CSF2 signal for proliferation, differentiation, and activation of (primarily) granulocyte and macrophage hematopoietic cells. (NCI)
C39048	Dendritic_Cell_Pathway	Immune_Response_Regulation_Pathway	Dendritic Cell Pathway|Dendritic cells in regulating TH1 and TH2 Development
C39049	DR3_and_DR4_5_Mediated_Apoptosis_Pathway	Apoptosis_Regulation_Pathway	DR3 and DR4/5 Mediated Apoptosis Pathway|Induction of apoptosis through DR3 and DR4/5 Death Receptors
C39050	Dicer_Pathway	Regulatory_Pathways	Dicer Pathway	The degradation of endogenous mRNA in a sequence-specific manner can be induced by dsRNA [RNA interference (RNAi)], antisense transcription, or viral infection.  In the current model for posttranscriptional gene silencing by RNAi, the ribonuclease III like enzyme Dicer processes dsRNA into small fragments (siRNA) of 21-25 nts.  The siRNA is incorporated into the RNA-induced silencing complex (RISC), which targets and degrades the homologous mRNA.  Most of the proteins in the RISC (with the exception of Ago2 and Dicer have not been identified) but likely contain endonuclease, helicase, exonuclease and homology scanning activity. (BioCarta)
C39051	Apoptotic_DNA_Fragmentation_Pathway	Apoptosis_Regulation_Pathway	Apoptotic DNA Fragmentation Pathway|Apoptotic DNA fragmentation and tissue homeostasis
C39052	Pain_Repression_Pathway	Other_Biochemical_Pathway	Pain Repression Pathway|Repression of Pain Sensation by the Transcriptional Regulator DREAM
C39053	MAP_Kinase_Regulation_Pathway	Regulatory_Pathways	MAP Kinase Regulation Pathway|Regulation of MAP Kinase Pathways Through Dual Specificity Phosphatases
C39054	Extracellular_Matrix_Binding_Pathway	Cell_Motility_Pathway	Extracellular Matrix Binding Pathway|Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia
C39055	Phospholipid_Signaling_Pathway	Signaling_Pathways	Phospholipid Signaling Pathway|Phospholipids as signaling intermediaries
C39056	Vesicle_Transport_Pathway	Other_Biochemical_Pathway	Vesicle Transport Pathway|The role of FYVE-finger proteins in vesicle transport
C39057	EFP_Cell_Cycle_Pathway	Cell_Cycle_Regulation_Pathway	EFP Cell Cycle Pathway|Estrogen-responsive protein Efp controls cell cycle and breast tumors growth	The estrogen-inducible RING finger protein Efp stimulates proliferation of breast cancer cells. 14-3-3 is p53-inducible protein that sequesters mitotic Cdks in the cytoplasm to inhibit entry into mitosis. To allow cell-cycle progression, estrogens stimulate production of Efp, which binds and ubiquinates 14-3-3s sigma. 14-3-3s marked with ubiquitin chains is recognized and destroyed by the proteosome. Released Cdks are now free to escape into the nucleus and promote mitotic entry.
C39058	EGF_Signaling_Pathway	Signaling_Pathways	EGF Signaling Pathway
C39059	Map_Kinase_Inactivation_of_SMRT_Corepressor_Pathway	Regulatory_Pathways	Map Kinase Inactivation of SMRT Corepressor Pathway|Map Kinase Inactivation of SMRT Corepressor	Corepressors are coregulators that interact with transcriptional silencers in a variety of pathways such as cell proliferation, differentiation and apoptosis.  Abnormal corepressor-silencer interactions have been implicated in a variety of human disease pathways including several types of leukemia. The regulation of the SMRT corepressor via the p38 and Mek-1 Kinase pathway is represented in this pathway.  The EFG receptor represents one mechanism by which SMRT function is inhibited by the tyrosine kinase signaling pathway. The MEKK1 and p38 pathways are activated by EGF resulting in cross-regulation of SMRT.  The induction of SMRT phosphorylation by either pathway causes SMRT to unbind from the transcription factor complexes represented by RXR, RAR, T3R and PLZF.
C39060	Eicosanoid_Metabolism_Pathway	Metabolic_Pathways	Eicosanoid Metabolism Pathway|Eicosanoid Metabolism
C39061	eIF2_Regulation_Pathway	Regulatory_Pathways	eIF2 Regulation Pathway|Regulation of eIF2	Protein phosphorylation plays an important role in the control of translation by eukaryotic initiation factor-2 (eIF-2). eIF-2 binds GTP and Met-tRNAi and transfers the Met-tRNA to the 40S subunit, to form the 43S preinitiation complex. Later in the cycle, prior to elongation, the bound GTP is hydrolyzed , releasing eIF-2-GDP. For eIF-2 to promote another round of initiation, GDP must be exchanged for GTP, a reaction catalyzed by eIF-2B. Kinases activated by viral infection (PKR), endoplasmic reticulum stress (PERK/PEK), amino acid deprivation (GCN2), and hemin deficiency (HRI) can phosphorylate the a subunit of eIF-2. This phosphorylation stabilizes the eIF-2-GDP-eIF-2B complex, inhibiting the turnover of eIF-2B. eIF-2B is also inhibited by GSK-3b phosphorylation. These events result in a shut-down of cellular protein synthesis and can lead to apoptosis.
C39062	eIF4_Regulation_Pathway	Regulatory_Pathways	eIF4 Regulation Pathway|Regulation of eIF4e and p70 S6 Kinase
C39063	Protein_Translation_Pathway	Other_Biochemical_Pathway	Protein Translation Pathway|Eukaryotic protein translation	The scanning translation initiation model suggests that 40S ribosomal subunit preloaded with factors bind to the 5' end of the mRNA near the cap.  The 48S subunit moves along the mRNA until it finds the initiation triplet and in complex with tRNA and 60S subunit forms the first peptide bond. Translation control is mostly regulated at the protein initiation step through translation initiation factors such as eIF2 or eIF4.
C39064	Allergy_Chemokine_Network_Pathway	Immune_Response_Regulation_Pathway	Allergy Chemokine Network Pathway|The Role of Eosinophils in the Chemokine Network of Allergy
C39065	Platelet_Aggregation_Pathway	Other_Biochemical_Pathway	Platelet Aggregation Pathway|Eph Kinases and ephrins support platelet aggregation
C39066	Erythropoietin_Neuroprotection_Pathway	Apoptosis_Regulation_Pathway	Erythropoietin Neuroprotection Pathway|Erythropoietin mediated neuroprotection through NF-kB
C39067	EPO_Signaling_Pathway	Signaling_Pathways	EPO Signaling Pathway	Erythropoietin functions to increase the number of red blood cells. Thus, it has found utility as a drug for those needing to replenish erythrocytes for any number of reasons. The signaling mechanism includes multimerization of the receptor upon ligand binding, activation of MAPK cascade, and phosphorylation and activation of Stat5.
C39069	ErbB3_Receptor_Recycling_Pathway	Protein_Cycling_Pathway	ErbB3 Receptor Recycling Pathway|Neuroregulin receptor degradation protein-1 Controls ErbB3 receptor recycling
C39070	Gamma-Secretase_Mediated_ErbB4_Signaling_Pathway	Signaling_Pathways	Gamma-Secretase Mediated ErbB4 Signaling Pathway|g-Secretase mediated ErbB4 Signaling Pathway	The HER4/erbB4 receptor tyrosine kinase is a member of the EGF1 receptor family. HER4 is a receptor for the neuregulins (NRGs), a family of growth and differentiation factors. HER4 can also bind and be activated by heparin-binding EGF growth factor, betacellulin, and epiregulin, members of the EGF family which, unlike the NRGs, are also ligands for the EGF receptor. HER4 mRNA is expressed in several tissues such as heart, brain, kidney, and skeletal muscle, suggesting that this receptor is involved in the development and maintenance of a variety of organs and cell types.  It is likely that the control of expression and function of HER4 is important in normal development as well as in disease.
C39071	Neuronal_Survival_Pathway	Other_Biochemical_Pathway	Neuronal Survival Pathway|Role of Erk5 in Neuronal Survival
C39072	Erk1_Erk2_MAPK_Signaling_Pathway	Signaling_Pathways	Erk1/Erk2 MAPK Signaling Pathway|Erk1/Erk2 Mapk Signaling pathway	The p44/42 MAP Kinase pathway consists of a protein kinase cascade linking growth and differentiation signals with transcription in the nucleus. Growth factor receptors and tyrosine kinases activate Ras which in turn activates c-Raf, MEK, and MAP kinase. Activated p44/42 MAP Kinase translocates to the nucleus and activates transcription by phosphorylation of kinases such as p90 RSK, MSK, and transcription factors such as ELK-1 and Stat3. The importance of this pathway in both growth control and development has been demonstrated via the transforming properties of various mutant forms of Ras, Raf, MEK and by their effects on development. Signal amplification and the potential for crosstalk appear to be important features of this regulatory network.
C39073	Erythrocyte_Differentiation_Pathway	Cell_Differentiation_or_Development_Pathway	Erythrocyte Differentiation Pathway	Stem cells in the bone marrow produce a variety of hematopoietic cell types from common progenitor cells under the influence of cytokines and growth factors. CFU-GEMM cells are a key intermediate in the differentiation of granulocytes, erythrocytes, monocytes and megakaryocytes. Erythropoietin (EPO) is a cytokine produced in the kidneys that, along with other cytokines, induces red blood cell (erythrocyte) differentiation in the bone marrow from CFU-GEMM cells. As the erythrocyte lineage progresses, cells lose their nuclei, and move out of the bone marrow into circulation. The ability of EPO to selectively induce red blood cell differentiation has allowed extensive therapeutic use of the recombinant form of this cytokine to treat anemias.
C39074	Electron_Transport_Pathway	Metabolic_Pathways	Electron Transport Pathway|Electron Transport Reaction in Mitochondria
C39075	Macrophage_Differentiation_Pathway	Cell_Differentiation_or_Development_Pathway	Macrophage Differentiation Pathway|METS affect on Macrophage Differentiation
C39076	Extrinsic_Prothrombin_Activation_Pathway	Protein_Activation_Pathway	Extrinsic Prothrombin Activation Pathway
C39077	Fas_Signaling_Pathway	Apoptosis_Regulation_Pathway|Signaling_Pathways	Fas Signaling Pathway|FAS signaling pathway ( CD95 )
C39078	Cyclin_E_Degradation_Pathway	Degradation_Pathway	Cyclin E Degradation Pathway|Cyclin E Destruction Pathway
C39079	Fc_Epsilon_Receptor_I_Signaling_Pathway	Signaling_Pathways	Fc Epsilon Receptor I Signaling Pathway|Fc Epsilon Receptor I Signaling in Mast Cells	The Fc Epsilon Receptor 1 signaling pathway in mast cells uses multiple core signal paths to achieve its necessary ends. Through the BTK protein and PKC Mast cells are able to degranulate, through the PKC and MAPK paths the cells are able to alter cytokine expression and arachidonic acid release. (BioCarta)
C39080	Fibrinolysis_Pathway	Other_Biochemical_Pathway	Fibrinolysis Pathway
C39081	Flumazenil_Cardioprotection_Pathway	Other_Biochemical_Pathway	Flumazenil Cardioprotection Pathway|Cardiac Protection Against ROS
C39082	Formyl_Peptide_Receptor_1_Signaling_Pathway	Signaling_Pathways	Formyl Peptide Receptor 1 Signaling Pathway|fMLP induced chemokine gene expression in HMC-1 cells
C39083	FosB_Drug-induction_Pathway	Other_Biochemical_Pathway	FosB Drug-induction Pathway|FOSB gene expression and drug abuse
C39084	Free_Radical_Induced_Apoptosis_Pathway	Apoptosis_Regulation_Pathway	Free Radical Induced Apoptosis Pathway|Free Radical Induced Apoptosis
C39085	Regulation_of_Cholesterol_Metabolism_Pathway	Metabolic_Pathways	Regulation of Cholesterol Metabolism Pathway|FXR and LXR Regulation of Cholesterol Metabolism
C39086	G1_S_Checkpoint_Pathway	Cell_Cycle_Regulation_Pathway	G1/S Checkpoint Pathway|Cell Cycle: G1/S Check Point
C39087	Leloir_Pathway_of_Galactose_Metabolism	Metabolic_Pathways	Leloir Pathway of Galactose Metabolism|Leloir pathway of galactose metabolism
C39088	G2_M_Checkpoint_Pathway	Cell_Cycle_Regulation_Pathway	G2/M Checkpoint Pathway|Cell Cycle: G2/M Checkpoint
C39089	GABA_Receptor_Life_Cycle_Pathway	Protein_Cycling_Pathway	GABA Receptor Life Cycle Pathway|Gamma-aminobutyric Acid Receptor Life Cycle
C39090	Th2_Cytokine_Gene_Induction_Pathway	Regulatory_Pathways	Th2 Cytokine Gene Induction Pathway|GATA3 participate in activating the Th2 cytokine genes expression
C39091	Corticosteroid_Cardioprotection_Pathway	Other_Biochemical_Pathway	Corticosteroid Cardioprotection Pathway|Corticosteroids and cardioprotection
C39092	Growth_Hormone_Signaling_Pathway	Signaling_Pathways	Growth Hormone Signaling Pathway	Growth hormone plays a major role in regulating growth during childhood and adolescence and also regulates metabolism. Defects in growth hormone signaling can result in dwarfism and decreases in growth hormone levels with age have been suggested to play a role in the reduced function of some physiological systems. Growth hormone signals a response in cells through the growth hormone receptor, a member of the cytokine receptor gene family. Growth hormone causes the receptor to dimerize, activating the JAK2 protein kinase. The activity of JAK2 mediates many of the downstream responses to growth hormone through phosphorylation of STAT transcription factors, MAP kinases, other kinase cascades and molecules involved in metabolism like IRS-1. Factors like SOCS and SHP-1 appear to play a role in the down regulation of signaling by growth hormone and cytokines. (BioCarta)
C39093	Food_Intake_and_Energy_Homeostasis_Pathway	Metabolic_Pathways	Food Intake and Energy Homeostasis Pathway|Ghrelin: Regulation of Food Intake and Energy Homeostasis
C39094	Inhibition_of_Cellular_Proliferation_by_Gleevec_Pathway	Other_Biochemical_Pathway	Inhibition of Cellular Proliferation by Gleevec Pathway|Inhibition of Cellular Proliferation by Gleevec
C39095	Glycolysis_Pathway	Metabolic_Pathways	Glycolysis Pathway
C39096	G-Protein_Signaling_Pathway	Signaling_Pathways	G-Protein Signaling Pathway|Signaling Pathway from G-Protein Families	G-aS-coupled receptors stimulate adenylyl cyclase (AC), which synthesizes cAMP from ATP.  In contrast Gai-coupled receptors inhibit AC and so reduce cAMP formation.  The bg subunits from Gai and other G proteins are able to activate the MAP kinase pathways and PLCb.  GPCRs coupled to the Gaq family of G proteins stimulate PLCb, which cleaves membrane phospholipids to produce IP3, which mobilizes intracellular calcium, and DAG, which activates PKC.  Second messenger pathways then activate a range of effector systems to change cell behavior; in many cases this includes the regulation of gene transcription. (BioCarta)
C39097	Granulocyte_Adhesion_Pathway	Cell_Motility_Pathway	Granulocyte Adhesion Pathway|Adhesion and Diapedesis of Granulocytes
C39098	Beta-Catenin_Accumulation_Pathway	Other_Biochemical_Pathway	Beta-Catenin Accumulation Pathway|Inactivation of Gsk3 by AKT causes accumulation of b-catenin in Alveolar Macrophages
C39099	Protein_Kinase_A_Activation_Pathway	Protein_Activation_Pathway	Protein Kinase A Activation Pathway|Activation of cAMP-dependent protein kinase, PKA
C39100	HBx_Signaling_Pathway	Infectious_Disease_Pathway|Signaling_Pathways	HBx Signaling Pathway|Calcium Signaling by HBx of Hepatitis B virus
C39101	Human_Cytomegalovirus_Infection_Pathway	Infectious_Disease_Pathway	Human Cytomegalovirus Infection Pathway|Human Cytomegalovirus and Map Kinase Pathways
C39102	Skeletal_Myogenesis_Pathway	Other_Biochemical_Pathway	Skeletal Myogenesis Pathway|Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK)
C39103	ERBB2_Signaling_Pathway	Signaling_Pathways	ERBB2 Signaling Pathway|Role of ERBB2 in Signal Transduction and Oncology
C39104	Segmentation_Clock_Pathway	Other_Biochemical_Pathway	Segmentation Clock Pathway|Segmentation Clock	In most animal species, the anteroposterior body axis is generated by the formation of repeated structures called segments. In vertebrate segmentation, a specialized mesodermal structure called the somite gives rise to skeletal muscles, vertebrae, and some dermis. Formation of the somites is a rhythmic process that involves an oscillator, the segmentation clock, driven by Wnt and Notch signaling. The clock ticks in somite precursors and halts when they reach a specific maturation stage defined as the wavefront, established by FGF and Wnt signaling. Lunatic fringe was shown to act downstream of Notch and to bind and negatively regulate its own promoter. Another cyclic gene is hes1. It acts also downstream of Notch and codes for an unstable protein able to negatively regulate its own promoter too. (BioCarta)
C39105	Hypoxia-Inducible_Factor_Pathway	Regulatory_Pathways	Hypoxia-Inducible Factor Pathway|Hypoxia-Inducible Factor in the Cardiovascular System
C39106	HIV-I_Nef_in_Apoptosis_Pathway	Apoptosis_Regulation_Pathway	HIV-I Nef in Apoptosis Pathway|HIV-I Nef: negative effector of Fas and TNF	HIV infection leads to drastic declines in CD4 T helper cells, in part through apoptosis of uninfected cells. Apoptosis of uninfected cells may be induced through the expression of Fas ligand on the surface of HIV-infected cells, stimulating the Fas-dependent apoptotic pathway in cells that come in contact with infected cells. The NEF protein expressed by HIV may play a role in the inducing the expression of Fas-ligand by infected cells. If this is the case, then a question that arises is how infected cells themselves escape Fas-mediated apoptosis. The NEF protein appears to play a role in this process as well. NEF interacts with the ASK1 kinase (apoptosis signal-regulating kinase) involved in apoptotic signaling by TNF and Fas-ligand. Interaction of NEF with ASK1 prevents phosphorylation of downstream MAP kinases and JNK kinases involved in apoptotic signaling. (BioCarta)
C39107	HOP_Pathway	Cell_Differentiation_or_Development_Pathway	HOP Pathway|Hop Pathway in Cardiac Development
C39108	HSP27_Regulation_Pathway	Regulatory_Pathways	HSP27 Regulation Pathway|Stress Induction of HSP Regulation
C39109	hSWI-SNF_Pathway	Other_Biochemical_Pathway	hSWI-SNF Pathway|Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes
C39110	Inhibition_of_Huntingtons_Disease_Pathway	Neurodegenerative_Disorders_Pathway	Inhibition of Huntington's Disease Pathway|Inhibition of Huntington's disease neurodegeneration by histone deacetylase inhibitors
C39111	IFN_Alpha_Signaling_Pathway	Signaling_Pathways	IFN Alpha Signaling Pathway|IFN alpha signaling pathway	Interferon alpha plays a role in viral infections. Signaling takes place through an IFN receptor complex consisting of two alpha chains (type I receptor) complexed with Jak1 and Tyk2. These kinases phosphorylate Stat1 and Stat2 respectively. (BioCarta)
C39112	IFN_Gamma_Signaling_Pathway	Signaling_Pathways	IFN Gamma Signaling Pathway|IFN gamma signaling pathway	Interferon gamma is secreted from CD4+ Th1 cells, CD8 cells, gamma/delta T cells, and activated NK cells. It plays a role in activating lymphocytes to enhance anti-microbial and anti-tumor effects. In addition it plays a role in regulating the proliferation, differentiation, and response of lymphocyte subsets. Signaling takes place through an IFN Receptor complex consisting of two alpha chains (type I receptor) and two beta chains (type 2 receptor). Upon phosphorylation by Jak1, Stat1 (alpha) transduces the signal into transcriptional events. (BioCarta)
C39113	Skeletal_Muscle_Hypertrophy_Pathway	Disease_Pathway	Skeletal Muscle Hypertrophy Pathway|Skeletal muscle hypertrophy is regulated via AKT/mTOR pathway
C39114	IGF-1_Signaling_Pathway	Signaling_Pathways	IGF-1 Signaling Pathway	Insulin like growth factor 1 (IGF-1) and its receptor (IGF-1R) provide a potent proliferative signaling system that stimulates growth in many different cell types and blocks apoptosis. In vivo IGF-1 acts as an intermediate of many growth hormone responses, and may stimulate the growth of some types of cancer. IGF-1 also provides a mitogenic signal to act as a growth factor for many tissue culture cells. One component of IGF-1 mitogenic signaling is association of the receptor tyrosine kinase with Shc, Grb2, and Sos-1 to activate ras and the Map kinase cascade (raf, Mek, Erk). An endpoint of the Map kinase pathway is modification of transcription factor activity, such as activation of ELK transcription factors. Serum response factor (SRF) and AP-1 contribute to mitogenic signaling by many factors. Phosphorylation of IRS-1 and PI3 kinase activation are also involved in IGF-1 signaling, similar to insulin signaling. (BioCarta)
C39115	IGF1R_Antiapoptosis_Pathway	Apoptosis_Regulation_Pathway	IGF1R Antiapoptosis Pathway|Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation	IGF-1R, the type 1 receptor for insulin-like growth factor, mediates cell survival and growth in response to its ligands IGF-1 and IGF-2. This tyrosine kinase receptor is widely expressed in many cell types and is a key mediator of growth. Overexpression or activation of IGF-1R may be involved in the proliferation of transformed cells, making inhibition of IGF-1R signaling a strategy for the development of cancer drugs. IGF-1R activates three signaling pathways that converge to phosphorylate BAD protein and block apoptosis. The first pathway activated by IGF-1R stimulates PI3-kinase and the AKT pathway to phosphorylate BAD and block apoptosis. A second pathway activated by IGF-1R involves ras mediated activation of the map kinase pathway to block apoptosis. A third pathway involves interaction of raf with mitochondria in response to IGF-1R activation. The convergence of these pathways to block apoptosis may enhance the IGF-1R response. (BioCarta)
C39116	IL10_Anti-inflammatory_Signaling_Pathway	Immune_Response_Regulation_Pathway|Signaling_Pathways	IL10 Anti-inflammatory Signaling Pathway|IL-10 Anti-inflammatory Signaling Pathway
C39117	IL12_Signaling_Pathway	Signaling_Pathways	IL12 Signaling Pathway|IL12 and Stat4 Dependent Signaling Pathway in Th1 Development
C39118	IL17_Signaling_Pathway	Signaling_Pathways	IL17 Signaling Pathway|IL 17 Signaling Pathway	Inflammation is a complex response involving many different cells and signaling molecules, including the secretion of the cytokine IL-17 by activated T cells. IL-17 secretion is restricted to specific subsets of T cells but the receptor for IL-17 is widely expressed throughout the body, including fibroblasts and epithelial cells. Inflammatory responses involving IL-17 probably contribute to arthritis, asthma, skin immune reactions, and autoimmune disorders. Fibroblasts and other cells stimulated by IL-17 are induced themselves to secrete inflammatory and hematopoietic cytokines, including IL-6, IL-8, G-CSF, and Stem Cell Factor (SCF). These cytokines in turn provoke a range of activities, including the stimulation of neutrophil proliferation and differentiation. (BioCarta)
C39119	IL18_Signaling_Pathway	Signaling_Pathways	IL18 Signaling Pathway|IL 18 Signaling Pathway	IL-18 is a pro-inflammatory cytokine similar in structure and mechanism of action to IL-1 beta. Formation of active IL-18 by macrophages requires cleavage of an inactive precursor by caspase-1 protease, also termed the IL-1 converting enzyme (ICE). One of the key biological responses induced by IL-18 is that, in combination with IL-12, it stimulates Th1 cell differentiation and involvement in immune responses. IL-18 was originally known as interferon-gamma-inducing factor, named after its induction of interferon-gamma production. Up-regulation of Fas ligand in Th1 cells by IL-18 may increase apoptosis of Fas receptor expressing cells that interact with the activated Th1 cells. This induction of apoptosis may allow IL-18 to have anti-tumor activity and may also play a role in chronic inflammatory and autoimmune conditions. (BioCarta)
C39120	IL1R_Signaling_Pathway	Signaling_Pathways	IL1R Signaling Pathway|Signal transduction through IL1R
C39121	IL22_Signaling_Pathway	Signaling_Pathways	IL22 Signaling Pathway|IL22 Soluble Receptor Signaling Pathway	IL-22 is an inflammatory cytokine related to IL-10 that is produced by T cells and that induces a response in cells through a heterodimeric cell surface receptor composed of IL-22R1 and IL-10R2C.  One of the actions of IL-22 appears to be the induction of acute phase inflammatory response in hepatocytes, acting through activation of STATs and transcriptional regulation.  A gene with homology to the extracellular domain of the cell surface IL-22R1 receptor component was identified that lacked transmembrane and cytoplasmic domains.  The protein derived from this gene was found to bind IL-22 and block its interaction with the cell surface receptor.  The IL-22 soluble receptor (IL-22BP, IL-22 binding protein) also blocks some of the downstream effects of IL-22 such as STAT activation and the transcriptional induction of genes involved in the immune and inflammatory responses.  The IL-22 soluble receptor may act as an anti-inflammatory agent. (BioCarta)
C39122	IL2_Signaling_Pathway	Signaling_Pathways	IL2 Signaling Pathway|IL 2 signaling pathway	Interleukin 2 (IL-2) is a potent cytokine that can lead to cellular activation and proliferation. IL-2 receptors are found on activated B-cells, LPS treated monocytes, and many T-cells. The receptor is formed from three chains, alpha (CD25), beta (CD122), and gamma (CD132). Primary signaling is through the JAK/Stat pathway and MAPKs. (BioCarta)
C39123	IL2RB_Pathway	Immune_Response_Regulation_Pathway	IL2RB Pathway|IL-2 Receptor Beta Chain in T cell Activation
C39124	IL3_Signaling_Pathway	Signaling_Pathways	IL3 Signaling Pathway|IL 3 signaling pathway	Interleukin-3 promotes the proliferation and differentiation of hematopoietic cells through binding to its receptor. The receptor for IL-3 is a heterodimer with a ligand-specific alpha chain (70 kD, CD123) and a common beta chain (shared with IL-5 and GM-CSF). Signaling is believed to be primarily through Stat5 and the MAPK pathways. (BioCarta)
C39125	IL4_Signaling_Pathway	Signaling_Pathways	IL4 Signaling Pathway|IL 4 signaling pathway	Interleukin 4 (IL-4) is a cytokine that can lead to development of Th2 cells. The 140 kD IL-4 Receptor (CD124) is found on many cell types, even those of non-hematopoietic origin. The receptor is formed from two chains: IL-4R-alpha and the IL-2R gamma chain (CD132). Primary signaling is through the JAK/Stat6 pathway and MAPKs. (BioCarta)
C39126	IL5_Signaling_Pathway	Signaling_Pathways	IL5 Signaling Pathway|IL 5 Signaling Pathway
C39127	IL6_Signaling_Pathway	Signaling_Pathways	IL6 Signaling Pathway|IL 6 signaling pathway
C39128	IL7_Signaling_Pathway	Signaling_Pathways	IL7 Signaling Pathway|IL-7 Signal Transduction
C39129	Inflammatory_Response_Pathway	Immune_Response_Regulation_Pathway	Inflammatory Response Pathway|Cytokines and Inflammatory Response
C39130	Insulin_Signaling_Pathway	Signaling_Pathways	Insulin Signaling Pathway	The appropriate signaling through the insulin pathway is critical for the regulation of glucose levels and the avoidance of diabetes. Insulin forms a complex with the insulin receptor (IR) and b chains to form the active signaling complex. Through recruitment of adaptor molecules and the activation of RAS, the activated IR can cause transcriptional activation. (BioCarta)
C39131	Integrin_Signaling_Pathway	Signaling_Pathways	Integrin Signaling Pathway
C39132	Intrinsic_Prothrombin_Activation_Pathway	Protein_Activation_Pathway	Intrinsic Prothrombin Activation Pathway
C39133	Ion_Channel_and_Phorbal_Esters_Signaling_Pathway	Signaling_Pathways	Ion Channel and Phorbal Esters Signaling Pathway
C39134	Internal_Ribosome_Entry_Pathway	Other_Biochemical_Pathway	Internal Ribosome Entry Pathway|Internal Ribosome entry pathway
C39135	Keratinocyte_Differentiation_Pathway	Cell_Differentiation_or_Development_Pathway	Keratinocyte Differentiation Pathway|Keratinocyte Differentiation
C39136	Local_Acute_Inflammatory_Response_Pathway	Immune_Response_Regulation_Pathway	Local Acute Inflammatory Response Pathway|local acute inflammatory response
C39137	LDL_Pathway	Disease_Pathway	LDL Pathway|Low-density lipoprotein (LDL) pathway during atherogenesis
C39138	Lectin_Induced_Complement_Pathway	Immune_Response_Regulation_Pathway	Lectin Induced Complement Pathway
C39139	Insulin_Resistance_Pathway	Disease_Pathway	Insulin Resistance Pathway|Reversal of Insulin Resistance by Leptin
C39140	LIS1_Pathway	Cell_Motility_Pathway	LIS1 Pathway|Lissencephaly gene (LIS1) in neuronal migration and development	LIS1 can bind to MT bundles; however, phospho-LIS1 binding to MT bundles is mediated through the distal zinc finger motif of CLIP-170.  When the distal zinc finger motif of CLIP-170 is mutated, the phospho-LIS1 isoform can no longer bind to MT bundles. This can also explain why p150/dynactin is not recruited to the MT bundles.  CLIP-170 targets the dynein/dynactin complex to the MT, using phopho-LIS1 as an adapter; the motor complex, being in the proximity of the MT, associates with it.  The initial static link to the MT provided by CLIP-170 is released by its hyperphosphorylation and the retrograde dynein/dynactin-dependent movement of the cargo (endocytic vesicle, kinetochore, etc.) takes place. Doublecortin (DCX) is placed close to the LIS1 pathway based on its interaction with LIS1 and its role in microtubule dynamics. (BioCarta)
C39141	Longevity_Pathway	Other_Biochemical_Pathway	Longevity Pathway|The IGF-1 Receptor and Longevity
C39142	Lymphocyte_Adhesion_Pathway	Cell_Motility_Pathway	Lymphocyte Adhesion Pathway|Adhesion and Diapedesis of Lymphocytes
C39143	Malate-Aspartate_Shuttle_Pathway	Metabolic_Pathways	Malate-Aspartate Shuttle Pathway|Malate-aspartate shuttle
C39144	Acetyl_Group_Shuttle_Pathway	Metabolic_Pathways	Acetyl Group Shuttle Pathway|Shuttle for transfer of acetyl groups from mitochondria to the cytosol
C39145	SRF_Activation_Pathway	Protein_Activation_Pathway	SRF Activation Pathway|Role of MAL in Rho-Mediated Activation of SRF
C39146	MAPKinase_Signaling_Pathway	Signaling_Pathways	MAPKinase Signaling Pathway
C39147	Calpain_Cell_Motility_Pathway	Cell_Motility_Pathway	mCalpain Cell Motility Pathway|mCalpain and friends in Cell motility
C39148	CDK_Regulation_Pathway	Regulatory_Pathways	CDK Regulation Pathway|CDK Regulation of DNA Replication
C39149	T-Cell_Apoptosis_Pathway	Apoptosis_Regulation_Pathway|Immune_Response_Regulation_Pathway	T-Cell Apoptosis Pathway|Role of MEF2D in T-cell Apoptosis	Mef2 (Myocyte enhancer factor 2) transcription factors play a role in T-Cell calcium induced apoptosis. Several factors regulate Mef2 transcription factors, including Map kinases and histone deacetylase (HDAC) enzymes. (BioCarta)
C39150	Melanocyte_Development_Pathway	Cell_Differentiation_or_Development_Pathway	Melanocyte Development Pathway|Melanocyte Development and Pigmentation Pathway	Studies with homozygous knockout mice have suggested that stem cell factor (SCF or KITLG), c-Kit, microphthalmia (Mitf), and B-cell CLL/lymphoma 2 (Bcl2) genes regulate melanocytic development.  The SCF activation of Kit receptor leads to Mitf phosphorylation through the MAP kinase pathway.  The activated Mitf recruits p300 and up-regulates Bcl2 transcription, which plays an important role in modulating the development and survival of the melanocyte lineage. (BioCarta)
C39151	Methionine_Isoleucine_Threonine_and_Valine_Degradation_Pathway	Degradation_Pathway	Methionine, Isoleucine, Threonine and Valine Degradation Pathway|Catabolic Pathways for Methionine, Isoleucine, Threonine and Valine	The carbon chains of methionine, isoleucine, threonine, and valine are broken down to produce succinyl-CoA, which feeds into the Citric Acid Cycle.  Methionine donates its methyl group via S-adenosylmethionine to one of several acceptors and the four remaining carbons are the backbone of propionyl-CoA that is subsequently converted to succinyl-CoA.  The transdeamination and decarboxylation of valine are followed by a series of steps resulting in the formation of propionyl-CoA.  Isoleucine also undergoes transdeamination, followed by oxidative decarboxylation.  These steps yield propionyl-CoA as well as acetyl-CoA.  Deficiency in the steps that convert isoleucine to propionyl-CoA causes sudden unexplained infant death, Reye-like syndrome, cardiomyopathy, and skeletal myopathy. (BioCarta)
C39152	Hepatocyte_Growth_Factor_Receptor_Signaling_Pathway	Signaling_Pathways	Hepatocyte Growth Factor Receptor Signaling Pathway|Signaling of Hepatocyte Growth Factor Receptor
C39153	Antigen_Presentation_Pathway	Immune_Response_Regulation_Pathway	Antigen Presentation Pathway|Antigen Processing and Presentation	Invariant chain (Ii) associates with newly synthesized class II molecules in the endoplasmic reticulum (ER), an interaction that has been shown to interfere with peptide binding to class II molecules. The class II-associated invariant chain peptide (CLIP) region (residues 81-104) of Ii is believed to mediate this inhibition by engaging the binding domain of class II like an antigenic peptide. Together, these findings have given rise to a model in which CLIP association with the class II groove acts to prevent inappropriate presentation of peptides imported into the ER for association with major histocompatibility complex class I molecules. (BioCarta)
C39154	Mitochondria_in_Apoptotic_Signaling_Pathway	Apoptosis_Regulation_Pathway|Signaling_Pathways	Mitochondria in Apoptotic Signaling Pathway|Role of Mitochondria in Apoptotic Signaling
C39155	Signal_Dependent_Regulation_of_Myogenesis_Pathway	Regulatory_Pathways	Signal Dependent Regulation of Myogenesis Pathway|Signal Dependent Regulation of Myogenesis by Corepressor MITR
C39156	Oocyte_Maturation_Pathway	Cell_Differentiation_or_Development_Pathway	Oocyte Maturation Pathway|How Progesterone Initiates the Oocyte Maturation	Progesterone (Pg) binds to both intracellular iPR and plasma membrane-bound mPR. After binding to Pg, iPR is recruited to the membrane associated protein tyrosine kinase p60c-src, which induces activation of the MAPK signaling pathway. This results in activation of p90Rsk and the subsequent phosphorylation and inactivation of Myt1, which favors formation of the activated cell cycle complex cyclin B-Cdc2. Activation of cyclin B-Cdc2 causes breakdown of the germinal vesicle and the initiation of oocyte maturation. In contrast, binding of Pg to mPR leads to inhibition of adenylyl cyclase (AC) through activation of Gai or inhibition of Gas. This leads to a decrease in the cAMP-dependent kinase PKA, which relieves inhibition of Cdc25C and also indirectly promotes the activation of MAPK signaling. PKA also regulates the initiation of oocyte maturation through other effects that are independent of PKA activity. (BioCarta)
C39157	Macrophage_Stimulating_1_Receptor_Signaling_Pathway	Signaling_Pathways	Macrophage Stimulating 1 Receptor Signaling Pathway|Msp/Ron Receptor Signaling Pathway
C39158	MTA3_Pathway	Disease_Pathway	MTA3 Pathway|Downregulated of MTA-3 in ER-negative Breast Tumors
C39159	mTOR_Signaling_Pathway	Signaling_Pathways	mTOR Signaling Pathway
C39160	Myosin_Phosphatase_Pathway	Regulatory_Pathways	Myosin Phosphatase Pathway|Myosin Pathway|PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase
C39161	Endocytosis_Pathway	Other_Biochemical_Pathway	Endocytosis Pathway|Endocytotic role of NDK, Phosphins and Dynamin
C39162	NFAT_Pathway	Disease_Pathway|Regulatory_Pathways	NFAT Pathway|NFAT and Hypertrophy of the heart (Transcription in the broken heart)
C39163	NFKB_Signaling_Pathway	Signaling_Pathways	NFKB Signaling Pathway|NF-kB Signaling Pathway
C39164	Nerve_Growth_Factor_Pathway	Signaling_Pathways	Nerve Growth Factor Pathway|Nerve growth factor pathway (NGF)
C39165	Ras-Independent_Cell-Mediated_Cytotoxicity_Pathway	Immune_Response_Regulation_Pathway	Ras-Independent Cell-Mediated Cytotoxicity Pathway|Ras-Independent pathway in NK cell-mediated cytotoxicity
C39166	T-Cell_Polarization_Pathway	Immune_Response_Regulation_Pathway	T-Cell Polarization Pathway
C39167	Nitric_Oxide_Pathway	Other_Biochemical_Pathway	Nitric Oxide Pathway|Actions of Nitric Oxide in the Heart
C39168	NO2-Dependent_IL12_Pathway	Immune_Response_Regulation_Pathway	NO2-Dependent IL12 Pathway|NO2-dependent IL 12 Pathway in NK cells
C39169	Nitric_Oxide_Signaling_Pathway	Signaling_Pathways	Nitric Oxide Signaling Pathway	Glutamatergic-mediated nitric oxide (NO) production occurs via the N-methyl-D-aspartic acid (NMDA) postsynaptic density protein 95 (PSD95)-neuronal nitric oxide synthase (NOS1) ternary complex. The increased intracellular Ca2+ stimulates the interaction of nNOS and calmodulin (CaM) and the translocation of nNOS from the plasma membrane to the cytoplasm. The dephosphorylation of nNOS by Calcineurin catalyzes the conversion of arginine to citrulline and nitric oxide (NO), which turns on guanylate cyclase and the various cGMP regulated signaling pathways. (BioCarta)
C39170	Notch_Signaling_Pathway	Signaling_Pathways	Notch Signaling Pathway|Proteolysis and Signaling Pathway of Notch
C39171	Protein_Import_into_Nucleus_Pathway	Other_Biochemical_Pathway	Protein Import into Nucleus Pathway|Mechanism of Protein Import into the Nucleus
C39172	Bone_Mineralization_Regulation_Pathway	Regulatory_Pathways	Bone Mineralization Regulation Pathway|Regulators of Bone Mineralization	Osteoblasts mineralize bone matrix by promoting hydroxyapatite crystal formation and growth in the interior of membrane-limited matrix vesicles (MVs) and by propagating the crystals onto the collagenous extracellular matrix. Two osteoblast proteins, tissue-nonspecific alkaline phosphatase (TNAP) and plasma cell membrane glycoprotein-1 (PC-1) are involved in this process. In the bone matrix, PC-1 is the major producer of PPi, which in turn has an inhibitory effect on hydroxyapatite deposition. TNAP has a positive influence on mineralization primarily by controlling the size of the inhibitory pool of PPi through its inorganic pyrophosphatase activity. TNAP also generates Pi by using NTPs and PPi as substrates, but other more major sources of Pi e.g., intestinal absorption, are likely to contribute the bulk of the Pi needed for hydroxyapatite deposition. (BioCarta)
C39173	NFKB_Activation_Pathway	Infectious_Disease_Pathway	NFKB Activation Pathway|NFkB activation by Nontypeable Hemophilus influenzae
C39174	Lipid_Metabolism_Pathway	Lipid_Metabolism_Reference_Pathway	Lipid Metabolism and Toxicity Pathway|Nuclear Receptors in Lipid Metabolism and Toxicity
C39175	OX40_Signaling_Pathway	Signaling_Pathways	OX40 Signaling Pathway	Two key features of the immune system are the clonal expansion of B cells and T cells in response to antigens, and the potentiation of future immune responses by long-lived memory cells.  CD4-expressing T cells require costimulatory signals along with antigen stimulation to mount an effective immune response.  CD28 has been widely characterized as a costimulatory receptor for CD4+ T cells.  OX40, also called CD134, is another transmembrane receptor protein expressed by CD4 T cells that provides a costimulatory signal for T cell activation by antigen.  The OX40L ligand for OX40 is expressed as a transmembrane protein by antigen-presenting cells, and is required for function of antigen-presenting cells.  The T cell costimulatory signal provided by the OX40/OX40L interaction increases the clonal amplification of antigen-specific T cells and the survival of memory T cells that respond to this antigen. (BioCarta)
C39176	p27_Regulation_Pathway	Regulatory_Pathways	p27 Regulation Pathway|Regulation of p27 Phosphorylation during Cell Cycle Progression
C39177	BioCarta_Alzheimers_Disease_Pathway	Neurodegenerative_Disorders_Pathway	Alzheimer's Disease Pathway 2|Deregulation of CDK5 in Alzheimers Disease
C39178	p38_MAPK_Signaling_Pathway	Signaling_Pathways	p38 MAPK Signaling Pathway	p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, and Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activates MKK3/5.  The p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, Max/Myc complex, MEF-2, ELK-1, and indirectly CREB via activation of MSK1. (BioCarta)
C39179	Hypoxia_Pathway	Disease_Pathway	Hypoxia Pathway|Hypoxia and p53 in the Cardiovascular system
C39180	p53_Signaling_Pathway	DNA_Repair_Pathway|Signaling_Pathways	p53 Signaling Pathway	p53 is a transcription factor who's activity is regulated by phosphorylation. The function is p53 is to keep the cell from progressing through the cell cycle if there is damage to DNA present. It may do this in multiple ways from holding the cell at a checkpoint until repairs can be made to causing the cell to enter apoptosis if the damage cannot be repaired. The critical role of p53 is evidenced by the fact that it is mutated in a very large fraction of tumors from nearly all sources. (BioCarta)
C39182	Ubiquitin-Proteasomal_Pathway	Degradation_Pathway	Ubiquitin-Proteasomal Pathway|Role of Parkin in the Ubiquitin-Proteasomal Pathway
C39183	IFN-Beta_Enhancer_Pathway	Regulatory_Pathways	IFN-Beta Enhancer Pathway|The information-processing pathway at the IFN-beta enhancer
C39184	PDGF_Signaling_Pathway	Signaling_Pathways	PDGF Signaling Pathway	Platelet Derived Growth Factor (PDGF) plays a critical role in cellular proliferation and development. The biologically active form is a dimer formed from the A and B chains. PDGF is active to a differing degree depending on which dimer is formed (AA, AB, or BB). The PDGF Receptor (PDGFR) is also a dimer and can form from the combination of the alpha and beta chains in any order (alpha-alpha, alpha-beta, beta-beta). The PDGFR dimer is only formed after ligand binding so the alpha/beta composition of the receptor can be influenced by the form of PDGF that is present. Upon binding of ligand the PDGFR is tyrosine phosphorylated and leads to the phosphorylation of several other cellular proteins. (BioCarta)
C39185	Synaptic_Junction_Pathway	Other_Biochemical_Pathway	Synaptic Junction Pathway|Synaptic Proteins at the Synaptic Junction	The postsynaptic density (PSD) is a submembranous structure at the postsynaptic membrane mainly at the excitatory synapses. The neurotransmitter receptors are assembled and fixed at the PSD, and several molecules implicated in the synaptic plasticity are also enriched. PSD-95/synapse-associated protein (SAP) 90 is involved in the molecular organization of these components of the PSD and essential for learning and memory. The common feature of these postsynaptic proteins is that they have PSD-95/Dlg/ZO-1 (PDZ) modular domains for protein-protein interaction. PDZ domains of these proteins directly recognize the C termini of their target proteins and are believed to play a central role in targeting and clustering of receptors to proper synaptic membranes. (BioCarta)
C39186	Pelp1_Estrogen_Receptor_Pathway	Other_Biochemical_Pathway	Pelp1 Estrogen Receptor Pathway|Pelp1 Modulation of Estrogen Receptor Activity
C39187	Wound_Repair_Pathway	Other_Biochemical_Pathway	Wound Repair Pathway|Proepithelin Conversion to Epithelin and Wound Repair Control
C39188	PGC1a_Regulation_Pathway	Regulatory_Pathways	PGC1a Regulation Pathway|Regulation of PGC-1a
C39189	Pitx2_Transcription_Regulation_Pathway	Regulatory_Pathways	Pitx2 Transcription Regulation Pathway|Multi-step Regulation of Transcription by Pitx2
C39190	Protein_Kinase_C_Activation_Pathway	Protein_Activation_Pathway	Protein Kinase C Activation Pathway|Activation of PKC through G protein coupled receptor
C39191	Platelet_Amyloid_Precursor_Protein_Pathway	Other_Biochemical_Pathway	Platelet Amyloid Precursor Protein Pathway	The amyloid-beta peptide (Ab), a proteolytic fragment of amyloid precursor protein (APP), is the major component of senile plaques, the hallmark of Alzheimer's disease.  Platelets contain both APP and Ab and probably contribute greater than 90% of circulating APP.  The soluble APP is the major inhibitor of coagulation factors IXa and XIa, and platelet aggregation.  Agonists such as ADP, thrombin, epinephrine and collagen activate the release of APP and plasminogen activator inhibitor I (an important regulator of coagulation) from platelet storage granules.  These important molecules released from platelets are key regulators of hemostasis, the physiologic arrest of hemorrhage at site of vascular leakage. (BioCarta)
C39192	Phospholipid_Associated_Cell_Signaling_Pathway	Signaling_Pathways	Phospholipid Associated Cell Signaling Pathway|Phospholipase C d1 in phospholipid associated cell signaling
C39193	Phospholipase_C-Epsilon_Signaling_Pathway	Signaling_Pathways	Phospholipase C-Epsilon Signaling Pathway|Phospholipase C-epsilon pathway	Proposed model for b2-AR- and prostanoid-receptor-mediated PLC and calcium signalling.  Receptors coupling to Gs stimulate AC, resulting in elevated cAMP levels and activation of Epac1.  Epac1 then catalyses GTP-loading on Rap2B, which leads to PLC-e activation.  The proposed pathway may involve additional signalling components to attain PLC stimulation. The action of cAMP seems to be independent of PKA; instead, the cAMP-activated Rap-GEF Epac seems to serve as a cAMP effector, inducing GTP loading and, hence, activation of Rap2B, which then leads to specific activation of PLC-e, which has been shown to interact with Rap GTPases. It is an attractive hypothesis, therefore, that the Rap-dependent PLC and calcium signalling pathway reported here is not restricted to Gs-and AC-coupled receptors, such as the b2-AR and the prostanoid receptor, but could be used by other receptors as well. (BioCarta)
C39194	Phospholipase_C_Signaling_Pathway	Signaling_Pathways	Phospholipase C Signaling Pathway	Phospholipase C comes in multiple forms and plays a key role in the signal transduction process for many receptors. Its main function is to hydrolyze phosphatidylinositol diphosphate into diacylglycerol (DG) and inositol triphosphate (IP3). DG is necessary for further activation of Protein Kinase C while IP3 leads to the release of intracellular calcium. (BioCarta)
C39195	Cell_Cycle_Progression_Pathway	Cell_Cycle_Regulation_Pathway	Cell Cycle Progression Pathway|Regulation of cell cycle progression by Plk3
C39196	Transcription_Regulation_Pathway	Regulatory_Pathways	Transcription Regulation Pathway|Regulation of transcriptional activity by PML
C39197	PPARa-alpha_Gene_Regulation_Pathway	Regulatory_Pathways	PPARa-alpha Gene Regulation Pathway|Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)
C39198	Obesity_and_Thermogenesis_Pathway	Other_Biochemical_Pathway	Obesity and Thermogenesis Pathway|Role of PPAR-gamma Coactivators in Obesity and Thermogenesis
C39199	PPAR_Pathway	Other_Biochemical_Pathway	PPAR Pathway|Basic mechanism of action of PPARa, PPARb(d) and PPARg and effects on gene expression	Similar to other nuclear hormone receptors, PPAR acts as a ligand activated transcription factor. Upon binding fatty acids or hypolipidemic drugs, PPARa interacts with RXR and regulates the expression of target genes. These genes are involved in the catabolism of fatty acids. Conversely, PPARg is activated by prostaglandins, leukotrienes, and anti-diabetic thiazolidinediones and affects the expression of genes involved in the storage of the fatty acids. PPARb is only weakly activated by fatty acids, prostaglandins, and leukotrienes and has no known physiologically relevant ligand. However, data from PPARb null mice suggest PPARb does serve a role in fatty acid metabolism and perhaps in skin proliferation and cancer. (BioCarta)
C39200	Gene_Silencing_Pathway	Regulatory_Pathways	Gene Silencing Pathway|The PRC2 Complex Sets Long-term Gene Silencing Through Modification of Histone Tails
C39201	Prion_Pathway	Neurodegenerative_Disorders_Pathway	Prion Pathway	Transmissible spongiform encephalopathy (TSE) is thought to result from the structural conversion of cellular prion protein, PrP(C), into a misfolded oligomeric form, PrP(Sc).  PrP is a cell membrane GPI anchored glycoprotein that is expressed in most tissues and in high levels in the nervous system. Some likely cellular functions of PrP are (1) cell protection against oxidative stress, (2) induction of neuronal cell adhesion, neurite extension and maintenance, and (3) neuroprotective signalling through a cAMP/PKA-dependent pathway. (BioCarta)
C39202	Notch_and_Wnt_Signaling_Pathway	Signaling_Pathways	Notch and Wnt Signaling Pathway|Presenilin action in Notch and Wnt signaling
C39203	Ptc1_Regulation_of_Cell_Cycle_Pathway	Cell_Cycle_Regulation_Pathway	Ptc1 Regulation of Cell Cycle Pathway|Sonic Hedgehog (SHH) Receptor Ptc1 Regulates cell cycle
C39204	Phosphoinositide_Pathway	Other_Biochemical_Pathway	Phosphoinositide Pathway|Phosphoinositides and their downstream targets
C39205	PTEN-Dependent_Cell_Cycle_Arrest_and_Apoptosis_Pathway	Apoptosis_Regulation_Pathway|Cell_Cycle_Regulation_Pathway	PTEN-Dependent Cell Cycle Arrest and Apoptosis Pathway|PTEN dependent cell cycle arrest and apoptosis
C39206	Pyk2_and_Map_Kinase_Pathway	Other_Biochemical_Pathway	Pyk2 and Map Kinase Pathway|Links between Pyk2 and Map Kinases	This pathway is a compilation of Pyk2 effort cascades; in specific cell types the receptor and effectors will vary.  Binding of a transmembrane receptor triggers the activation of Ca2+ signaling and PKC.  The signal is then transmitted to Pyk2 and further to the small G protein Rac1. In turn, Rac1 initiatives the JNK cascade, starting with PAK followed by MEKK1, SEK1, and JNK.  JNK activation causes induction of c-Jun gene binding.  Pyk2 stimulation has also been shown to activate MKK3 leading to activation of p38.  The other major mitogen activated kinase cascade for ERK1/2 is stimulated via RAS, RAF and MEKK1/2. (BioCarta)
C39207	Rab_GTPases_in_Endocytosis_Pathway	Other_Biochemical_Pathway	Rab GTPases in Endocytosis Pathway|Rab GTPases Mark Targets in the Endocytotic Machinery
C39208	Rac1_Cell_Motility_Signaling_Pathway	Signaling_Pathways	Rac1 Cell Motility Signaling Pathway|Rac 1 cell motility signaling pathway
C39209	Ion_Channels_in_Vascular_Endothelium_Pathway	Regulatory_Pathways	Ion Channels in Vascular Endothelium Pathway|Ion Channels and Their Functional Role in Vascular Endothelium
C39210	G1_to_S_Transition_Pathway	Cell_Cycle_Regulation_Pathway	G1 to S Transition Pathway|Influence of Ras and Rho proteins on G1 to S Transition
C39211	Sumoylation_Regulation_of_Transcriptional_Repression_Pathway	Regulatory_Pathways	Sumoylation Regulation of Transcriptional Repression Pathway|Sumoylation by RanBP2 Regulates Transcriptional Repression	Current data indicates that nuclear pore complex (NPC) RanBP2 (SUMO E3 ligase) protein sumoylates Mdm2 and HDAC proteins during nuclear translocation. A sumoylation-deficient HDAC showed reduced deacetylation activity and suggests that sumoylation may be an important regulatory mechanism for the control of transcriptional repression. (BioCarta)
C39212	Bone_Remodelling_Pathway	Cell_Differentiation_or_Development_Pathway	Bone Remodelling Pathway|Bone Remodelling
C39213	Mitotic_Spindle_Regulation_Pathway	Regulatory_Pathways	Mitotic Spindle Regulation Pathway|Role of Ran in mitotic spindle regulation
C39214	Ran_Cycling_Pathway	Protein_Cycling_Pathway	Ran Cycling Pathway|Cycling of Ran in nucleocytoplasmic transport	Ran is a member of the Ras family of small GTPases.  Ran is an important component of many crucial nucleocytoplasmic transport pathways.  The cycling of Ran is controlled by the RanGTP-RanGDP gradient established by the Ran Guanine nucleotide exchange Factor (RanGEF) RCC1 and the Ran GTPase-activating Protein (RanGAP).  These two proteins combine to create a Ran gradient where RanGDP is predominantly cytoplasmic.  RCC1 binds to chromatin and so RanGTP is found associated with DNA.  RCC1 dissociated GDP from Ran and allows GTP to be bound.  As Ran leaves the nucleus the two Ran binding proteins, RanBP1 and RanBP2 cooperate with RanGAP to induce GTP hydrolysis of Ran.  There are several nuclear import factors that use the Ran gradient as part of their translocation mechanism. (BioCarta)
C39215	RAR_and_RXR_Degradation_Pathway	Degradation_Pathway	RAR and RXR Degradation Pathway|Degradation of the RAR and RXR by the proteasome	Once retinoids are bound by the RAR/RXR heterodimer they became transcriptional activated. As a consequence they are degraded by the proteasome. Phosphorylation in the activation domain one (AF1) and presence of the activation domain 2 (AF2) trigger the ubiquitination of the receptors. Moreover, heterodimerization of RAR and RXR accelerate degradation of the receptors. (BioCarta)
C39216	Chromatin_Remodeling_Complex_and_Coactivator_Pathway	Regulatory_Pathways	Chromatin Remodeling Complex and Coactivator Pathway|Nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells	RXR and RAR are nuclear receptors that bind either all trans retinoic (tRA) or 9cis retinoic acid (9cisRA). In the absence of ligand corepressors with histone deacetylase activity are bound to the RAR/RXR hetrodimer and suppress transcription. Once they bind retinoic acid a conformational change in the receptors cause the dissociation of the corepressors and the binding of coactivators with histone acetylase activity. Following ligand binding by the hetrodimer the receptors and proteins in the basal transcription machinery (like TBP and TAF135) are degraded by the proteasome. (BioCarta)
C39217	Ras_Signaling_Pathway	Signaling_Pathways	Ras Signaling Pathway
C39218	RB_Checkpoint_Signaling_Pathway	Cell_Cycle_Regulation_Pathway|Signaling_Pathways	RB Checkpoint Signaling Pathway|RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage
C39219	Inhibition_of_Matrix_Metalloproteinases_Pathway	Regulatory_Pathways	Inhibition of Matrix Metalloproteinases Pathway|Inhibition of Matrix Metalloproteinases
C39220	Reelin_Signaling_Pathway	Signaling_Pathways	Reelin Signaling Pathway
C39221	RELA_Pathway	Other_Biochemical_Pathway	RELA Pathway|Acetylation and Deacetylation of RelA in The Nucleus
C39222	Visual_Signal_Transduction_Pathway	Signaling_Pathways	Visual Signal Transduction Pathway|Visual Signal Transduction
C39223	Rho_Cell_Motility_Signaling_Pathway	Signaling_Pathways	Rho Cell Motility Signaling Pathway|Rho cell motility signaling pathway
C39224	dsRNA_Induction_Pathway	Immune_Response_Regulation_Pathway	dsRNA Induction Pathway|Double Stranded RNA Induced Gene Expression	One defense against viral infection is provided by PKR, double-stranded RNA activated protein kinase. When PKR interacts with dsRNA found in cells during viral infection, PKR phosphorylates itself and cellular proteins including the translation factor elF2a and the transcription factor NF-kB. The repression of translation caused by phosphorylation of elF2a prevents cells from producing viral proteins and creating infectious viral particles. PKR phosphorylation of I-kB kinase activates NF-kB to induce transcription of inflammatory factors and stimulate an immune response that impedes viral infection. The PKR kinase is induced by interferon and some of the anti-viral activity of interferon may be mediated by PKR. Some viruses have evolved mechanisms to inactivate PKR to promote successful infection. Another substrate of PKR, the tumor suppressor p53, may be involved in potential PKR regulation of the cell cycle and apoptosis. (BioCarta)
C39225	RNA_Polymerase_III_Transcription_Pathway	Regulatory_Pathways	RNA Polymerase III Transcription Pathway|RNA polymerase III transcription
C39226	Lipid_Synthesis_Pathway	Lipid_Metabolism_Reference_Pathway	Lipid Synthesis Pathway|SREBP control of lipid synthesis
C39227	Salmonella_Pathway	Infectious_Disease_Pathway	Salmonella Pathway|How does salmonella hijack a cell
C39228	Splicing_Regulation_Pathway	Regulatory_Pathways	Splicing Regulation Pathway|Regulation of Splicing through Sam68
C39229	SARS_Coronavirus_Protease_Pathway	Infectious_Disease_Pathway	SARS Coronavirus Protease Pathway|SARS Coronavirus Protease
C39230	Granzyme_A_Mediated_Apoptosis_Pathway	Apoptosis_Regulation_Pathway	Granzyme A Mediated Apoptosis Pathway|Granzyme A mediated Apoptosis Pathway
C39231	Sonic_Hedgehog_Pathway	Other_Biochemical_Pathway	Sonic Hedgehog Pathway|Sonic Hedgehog (Shh) Pathway
C39232	E2F1_Degradation_Pathway	Degradation_Pathway	E2F1 Degradation Pathway|E2F1 Destruction Pathway
C39233	Spliceosome_Assembly_Pathway	Other_Biochemical_Pathway	Spliceosome Assembly Pathway|Spliceosome Assembly
C39234	SODD_TNFR1_Signaling_Pathway	Signaling_Pathways	SODD/TNFR1 Signaling Pathway
C39235	Aspirin_Inhibition_of_Platelet_Activation_Pathway	Signaling_Pathways	Aspirin Inhibition of Platelet Activation Pathway|Aspirin Blocks Signaling Pathway Involved in Platelet Activation
C39236	Sprouty_Regulation_of_Tyrosine_Kinase_Signaling_Pathway	Signaling_Pathways	Sprouty Regulation of Tyrosine Kinase Signaling Pathway|Sprouty regulation of tyrosine kinase signals
C39237	SRC_Tyrosine_Kinase_Activation_Pathway	Protein_Activation_Pathway	SRC Tyrosine Kinase Activation Pathway|Activation of Src by Protein-tyrosine phosphatase alpha
C39238	Stat3_Signaling_Pathway	Signaling_Pathways	Stat3 Signaling Pathway
C39239	Stathmin_Pathway	Other_Biochemical_Pathway	Stathmin Pathway|Stathmin and breast cancer resistance to antimicrotubule agents
C39240	Hematopoiesis_Pathway	Cell_Differentiation_or_Development_Pathway	Hematopoiesis Pathway|Regulation of hematopoiesis by cytokines	The process of hematopoiesis is regulated by various cytokines.  The combination of cytokines stimulates the proliferation and/or differentiation of the various hematopoietic cell types.  Bone marrow stromal cells are the major source of hematopoietic cytokines in the non-infectious state.  In the presence of infection, cytokines produced by activated macrophages and TH cells induce hematopoietic activity.  The induction by cytokines results in rapid expansion of the population of white blood cells to fight infection. (BioCarta)
C39241	TNF_Stress_Related_Signaling_Pathway	Signaling_Pathways	TNF Stress Related Signaling Pathway|TNF/Stress Related Signaling
C39242	Sumoylation_Pathway	Other_Biochemical_Pathway	Sumoylation Pathway|Basic Mechanisms of SUMOylation
C39243	B-Cell_Immune_Response_Pathway	Immune_Response_Regulation_Pathway	B-Cell Immune Response Pathway|TACI and BCMA stimulation of B cell immune responses	APRIL and BAFF (also called TALL-I and BLyS) are TNF family members that act as ligands for the BCMA and TACI receptors. Both APRIL and BAFF bind to both the BCMA and TACI receptors to activate the humoral immune response, stimulating B cell immunoglobulin production and proliferation. BAFF is found as a membrane bound form in T cells and a soluble form that is released from the cell to stimulate B cell proliferation and differentiation. As members of the TNF receptor gene family, BCMA and TACI interact with TRAF family members to transduce signals downstream to NF-kappaB activation and MAP kinase pathways. Abnormally active BAFF or APRIL signaling may play a role in autoimmune disorders such as lupus. (BioCarta)
C39244	HIV_Induced_T_Cell_Apoptosis_Pathway	Apoptosis_Regulation_Pathway	HIV Induced T Cell Apoptosis Pathway|HIV Induced T Cell Apoptosis	HIV infection is associated with immunosuppression caused by a dramatic reduction in the helper T cell population. The loss of helper T cells may be caused by HIV-induced apoptosis of both infected and uninfected helper T cells. HIV uses the CCR5 chemokine receptor as a coreceptor for macrophage cell entry and upregulates fas-ligand on these cells. CD4 on helper T cells is essential for viral cell entry and infection. Cross-linking of CD4 on the T cell surface may be involved in upregulation of Fas and sensitization of T cells to apoptosis induced by the Fas/Fas-ligand interaction. (BioCarta)
C39245	TCR_Activation_Pathway	Immune_Response_Regulation_Pathway	TCR Activation Pathway|Lck and Fyn tyrosine kinases in initiation of TCR Activation	T cell activation is initiated by recognition of antigen by the T cell receptor (TCR) in the context of Class II MHC on an antigen-presenting cell. The T cell receptor contains multiple subunits and interacts with several factors to transduce antigen-stimulated T cell activation. One of the key steps that initiates receptor activation is the tyrosine phosphorylation of TCR subunits by the src family protein kinases Lck and Fyn. T cell receptor phosphorylated by Lck and Fyn recruits the ZAP-70 protein kinase to the receptor complex, which becomes activated and stimulates downstream pathways like the Map kinase cascade. The CD45 protein tyrosine phosphatase activates Lck and Fyn by dephosphorylating these proteins and is required for TCR activation. Association of the CD4 coreceptor with Lck may also be involved in Lck activation. (BioCarta)
C39246	T_Cell_Receptor_Signaling_Pathway	Immune_Response_Regulation_Pathway|Signaling_Pathways	T Cell Receptor Signaling Pathway	The T Cell Receptor plays a key role in the immune system. The specificity of the receptor is governed by the binding site formed from the mature alpha and beta chains or gamma and delta chains in gamma/delta T Cells. It is the ability of this receptor to bind a complex of foreign peptide in the groove of an MHC molecule that leads to T cell activation. Upon activation the T cell can assist in activating other cells or carry out cytolytic attacks depending on the particular T cell type. The CD3 complex and CD4 (Th cells) or CD8 (Tc cells) work to transmit the activation signal to the T cell's transcriptional machinery upon engagement of the receptor. (BioCarta)
C39247	Telomere_Pathway	Other_Biochemical_Pathway	Telomere Pathway|Telomeres, Telomerase, Cellular Aging, and Immortality
C39248	Terc_Regulation_Pathway	Regulatory_Pathways	Terc Regulation Pathway|Overview of telomerase RNA component gene hTerc Transcriptional Regulation
C39249	Tert_Regulation_Pathway	Regulatory_Pathways	Tert Regulation Pathway|Overview of telomerase protein component gene hTert Transcriptional Regulation
C39250	Mucosal_Healing_Pathway	Cell_Motility_Pathway	Mucosal Healing Pathway|Trefoil Factors Initiate Mucosal Healing
C39251	TGF_Beta_Signaling_Pathway	Signaling_Pathways	TGF Beta Signaling Pathway|TGF beta signaling pathway
C39252	Th1_Th2_Differentiation_Pathway	Cell_Differentiation_or_Development_Pathway	Th1/Th2 Differentiation Pathway|Th1/Th2 Differentiation
C39253	Interferon_Signaling_Modulation_Pathway	Signaling_Pathways	Interferon Signaling Modulation Pathway|Chaperones modulate interferon Signaling Pathway
C39254	TNFR1_Signaling_Pathway	Signaling_Pathways	TNFR1 Signaling Pathway	TNFR1 (p55, CD120a) is the receptor for TNF-alpha and also will bind TNF-beta. Upon binding TNF-alpha a TNFR1+ cell is triggered to undergo apoptosis. This critical regulatory process is accomplished by activating the proteolytic caspase cascade that results in the degradation of many critical cellular proteins. (BioCarta)
C39255	TNFR2_Signaling_Pathway	Signaling_Pathways	TNFR2 Signaling Pathway	TNFR2 is the receptor for the 171 amino acid 19 kD TNF-beta (a.k.a. lymphotoxin). TNF-beta is produced by activated lymphocytes and can be cytotoxic to many tumor and other cells. In neutrophils, endothelial cells and osteoclasts TNF-beta can lead to activation while in many other cell types it can lead to increased expression of MHC and adhesion molecules. (BioCarta)
C39256	T-Cell_Activation_Pathway	Immune_Response_Regulation_Pathway	T-Cell Activation Pathway|Role of Tob in T-cell activation
C39257	Toll-Like_Receptor_Pathway	Other_Biochemical_Pathway	Toll-Like Receptor Pathway
C39258	TPO_Signaling_Pathway	Signaling_Pathways	TPO Signaling Pathway	Thrombopoietin (TPO) binds to its receptor, inducing aggregation and activation. TPO signals its growth regulating effects to the cell through several major pathways including MAPK (ERK and JNK), Protein Kinase C, and JAK/Stat. (BioCarta)
C39259	Trka_Receptor_Signaling_Pathway	Signaling_Pathways	Trka Receptor Signaling Pathway	Nerve growth factor (NGF) is a neurotrophic factor that stimulates neuronal survival and growth through TrkA, a member of the trk family of tyrosine kinase receptors that also includes TrkB and TrkC. Some NGF responses are also mediated or modified by p75LNTR, a low affinity neurotrophin receptor. Binding of NGF to TrkA stimulates neuronal survival, and also proliferation. Pathways coupled to these responses are linked to TrkA through association of signaling factors with specific amino acids in the TrkA cytoplasmic domain. Cell survival through inhibition of apoptosis is signaled through activation of PI3-kinase and AKT. Ras-mediated signaling and phospholipase C both activate the MAP kinase pathway to stimulate proliferation. (BioCarta)
C39260	TSP-1_Induced_Apoptosis_Pathway	Apoptosis_Regulation_Pathway	TSP-1 Induced Apoptosis Pathway|TSP-1 Induced Apoptosis in Microvascular Endothelial Cell	As tissues grow they require angiogenesis to occur if they are to be supplied with blood vessels and survive. Factors that inhibit angiogenesis might act as cancer therapeutics by blocking vessel formation in tumors and starving cancer cells. Thrombospondin-1 (TSP-1) is a protein that inhibits angiogenesis and slows tumor growth, apparently by inducing apoptosis of microvascular endothelial cells that line blood vessels. TSP-1 appears to produce this response by activating a signaling pathway that begins with its receptor, CD36, at the cell surface of the microvascular endothelial cell. The non-receptor tyrosine kinase fyn is activated by TSP-1 through CD36, activating the apoptosis inducing proteases such as caspase-3 and p38 protein kinases. p38 is a mitogen-activated kinase that also induces apoptosis in some conditions, perhaps through AP-1 activation and the activation of genes that lead to apoptosis. (BioCarta)
C39261	Tubby_Signaling_Pathway	Signaling_Pathways	Tubby Signaling Pathway|G-Protein Signaling Through Tubby Proteins
C39262	uCalpain_Cell_Spread_Pathway	Cell_Motility_Pathway	uCalpain Cell Spread Pathway|uCalpain and friends in Cell spread	The mammalian calpain gene family currently contains 13 distinct large subunit products most of which complex with one of two smaller 30kDa subunits. Spreading cells display newly transiently formed integrin adhesion clusters containing Calpain1 (mu-Calpain), cleaved Talin, B3-Integrin, and SPTAN1 (Spectrin).  Recruitment of Rac to these clusters leads to the activation of Rac and the formation of Rac-induced focal clusters.  The Calpain1 in the integrin clusters initially inactivates RhoA allowing for the formation of lamellipodia.  The subsequent activation of newly synthesized RhoA transforms these clusters into Focal Adhesion Complexes and the formation of contractile actin-myosin stress fibers.  These mature adhesions do not contain calpain. (BioCarta)
C39263	Gene_Expression_Regulation_by_Vitamin_D_Receptor_Pathway	Regulatory_Pathways	Gene Expression Regulation by Vitamin D Receptor Pathway|Control of Gene Expression by Vitamin D Receptor
C39264	Angiogenesis_Pathway	Other_Biochemical_Pathway	Angiogenesis Pathway|VEGF, Hypoxia, and Angiogenesis
C39265	HIV-1_Infection_Pathway	Infectious_Disease_Pathway	HIV-1 Infection Pathway|HIV-1 defeats host-mediated resistance by CEM15
C39266	T-Cell_Antiapoptosis_Pathway	Apoptosis_Regulation_Pathway|Immune_Response_Regulation_Pathway	T-Cell Antiapoptosis Pathway|Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells	Vasoactive intestinal peptide (VIP) and the structurally related pituitary adenylate cyclase-activating polypeptide (PACAP), two neuropeptides present in the lymphoid microenvironment, elicit a broad spectrum of biological functions, including the modulation of innate and adaptive immunity. Another important immunoregulatory function of VIP and PACAP is their inhibition effect on AICD in T cells. They inhibit the TCR-stimulated FasL expression and apoptosis of T cell through specific receptors and induction of intracellular cAMP. VIP down-regulate c-Myc synthesis, the NF-AT-dependent Egr2 and Egr3 expression, the NF-AT and NF-kB. (BioCarta)
C39267	Vitamin_C_in_Brain_Pathway	Other_Biochemical_Pathway	Vitamin C in Brain Pathway|Vitamin C in the Brain
C39268	Metabolic_Syndrome_Pathway	Disease_Pathway	Metabolic Syndrome Pathway|Visceral Fat Deposits and the Metabolic Syndrome
C39269	Wnt_LRP6_Signaling_Pathway	Signaling_Pathways	Wnt/LRP6 Signaling Pathway|Wnt/LRP6 Signaling	Wnt glycoproteins play a role in diverse processes during embryonic patterning in metazoa through interaction with frizzled-type seven-transmembrane-domain receptors (Frz) to stabilize b-catenin.  LDL-receptor-related protein 6 (LRP6), a Wnt co-receptor, is required for this interaction.  Dikkopf (dkk) proteins are both positive and negative modulators of this signaling. (BioCarta)
C39270	WNT_Signaling_Pathway	Signaling_Pathways	WNT Signaling Pathway	Wnt family members are secreted glycoproteins that bind to cell surface receptors such as Frizzled. Wnt members can play a role in the expression of many genes by interacting with multiple disparate signaling pathways. (BioCarta)
C39271	West_Nile_Virus_Pathway	Infectious_Disease_Pathway	West Nile Virus Pathway|West Nile Virus
C39272	Colony_Stimulating_Factor-2-Receptor_Alpha_Chain	Colony_Stimulating_Factor_Receptor	Colony Stimulating Factor 2 Receptor Alpha Chain|CD116|CD116 Antigen|CDw116|CSF2R|CSF2RA|GM-CSF Receptor Alpha Subunit|GM-CSF-R-Alpha|GMCSFR|GMR|Granulocyte-Macrophage Colony-Stimulating Factor Receptor Alpha Chain|Low Affinity Granulocyte-Macrophage Colony Stimulating Factor 2 Receptor Alpha	Expressed as alternative membrane-bound and soluble isoforms (3, 4, and 6) by human CSF2RA Gene (Type I Cytokine Receptor 5 Family), Colony Stimulating Factor 2 Receptor Alpha Chain is a type I membrane protein with a box 1 motif for JAK interaction/activation; a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding; and the alpha subunit of a heterodimeric low affinity receptor for granulocyte-macrophage colony-stimulating factor. The receptor signal transducing beta chain is common to the IL3-, IL5- and GM-CSF receptors. CSF2R transduces the CSF2 signal for proliferation, differentiation, and activation of (primarily) granulocyte and macrophage hematopoietic cells. (NCI)
C39273	Interleukin-3_Receptor	Protein_or_Riboprotein_Complex	Interleukin 3 Receptor|IL-3 Receptor	Heterodimeric human Interleukin 3 Receptor is composed of 378-aa 43-kDa (precursor) Interleukin 3 Receptor Alpha and GM-CSF/IL-3/IL-5 Receptor Common Beta-Chain. IL3RA is a type I membrane protein with a box 1 motif for JAK interaction/activation and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. Receptor binding to IL3 depends on the signal transducing beta subunit, common to the high affinity IL3-, IL5- and GM-CSF receptors. (NCI)
C39274	IL3RA_Gene	Cytokine_Receptor_Gene	IL3RA Gene|CD123|IL3R|IL3RA|IL3RAX|IL3RX|Interleukin 3 Receptor, Alpha (Low Affinity) Gene	Human IL3RA Gene (Type I Cytokine Receptor 5 Family) encodes 378-aa 43-kDa (precursor) Interleukin 3 Receptor Alpha, a type I membrane protein with a box 1 motif for JAK interaction/activation; a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding; and the ligand-binding alpha subunit of a heterodimeric cytokine receptor for Interleukin 3. Receptor binding to IL3 depends on the signal transducing beta subunit, shared by IL3-, IL5-, and CSF2/GM-CSF receptors. (NCI)
C39275	Interleukin-3_Receptor_Alpha	Cytokine_Receptor	Interleukin 3 Receptor Alpha|CD123|CD123 Antigen|IL3R|IL3R-Alpha|IL3RA|IL3RX|Interleukin 3 Receptor|Interleukin 3 Receptor Alpha Chain|Low Affinity Interleukin 3 Receptor Alpha	Encoded by human IL3RA Gene (Type I Cytokine Receptor 5 Family), 378-aa 43-kDa (precursor) Interleukin 3 Receptor Alpha is a type I membrane protein with a box 1 motif for JAK interaction/activation; a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding; and the ligand-binding alpha subunit of a heterodimeric cytokine receptor for Interleukin 3. Receptor binding to IL3 depends on the signal transducing beta subunit, shared by IL3-, IL5-, and CSF2/GM-CSF receptors. (NCI)
C39276	BioCarta_Parkinsons_Disease_Pathway	Neurodegenerative_Disorders_Pathway	Parkinson's Disease Pathway 2|Alpha-synuclein and Parkin-mediated proteolysis in Parkinson's disease
C39277	_4-1BB-Dependent_Immune_Response_Pathway	Immune_Response_Regulation_Pathway	4-1BB-Dependent Immune Response Pathway
C39278	Thrombin_Protease-Activated_Receptor_Signaling_Pathway	Signaling_Pathways	Thrombin/Protease-Activated Receptor Signaling Pathway
C39280	BioCarta_Myosin_Pathway	Retired_Concepts	Myosin Pathway|PKC-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase
C39281	CDC91L1_Gene	Protein_Complex_Subunit_Gene	CDC91L1 Gene|CDC91 Cell Division Cycle 91-Like 1 (S. Cerevisiae) Gene|CDC91L1|PIGU	Ubiquitously expressed (2 alternative isoforms) 12-exon 110-kb human CDC91L1 Gene (PIGU Family) encodes conserved 435-aa 50-kD GPI Transamidase Component PIGU, an integral ER membrane protein containing 9 putative transmembrane domains, with similarity to Cdc91 (S. cerevisiae), and a critical subunit of the GPI transamidase complex (PIGU, PIGK/GPI8, PIGS, PIGT, and GPAA1/GAA1) that attaches posttranslational GPI-anchors to the C-termini of cell surface proteins attached to membranes via GPI. PIGU may be involved in recognition of the GPI attachment signal or the lipid portion of GPI. (NCI)
C39282	GPI-Transamidase_Component-PIGU	Protein_Complex_Subunit	GPI Transamidase Component PIGU|CDC91-Like 1 Protein|CDC91L1|Cell Division Cycle 91-Like 1 Protein|Cell Division Cycle Protein 91-Like 1 Protein|GPI Transamidase Component|PIGU|Phosphatidylinositol-Glycan Biosynthesis Class U Protein|UNQ3055/PRO9875	Ubiquitously expressed by human CDC91L1 Gene (PIGU Family), conserved 435-aa 50-kD GPI Transamidase Component PIGU is an integral ER membrane protein containing 9 putative transmembrane domains, with similarity to Cdc91 (S. cerevisiae), and a critical subunit of the GPI transamidase complex (PIGU, PIGK/GPI8, PIGS, PIGT, and GPAA1/GAA1) that attaches posttranslational GPI-anchors to the C-termini of cell surface proteins attached to membranes via GPI. PIGU may be involved in recognition of the GPI attachment signal or the lipid portion of GPI. (NCI)
C39283	FOLR1_Gene	Receptor_Gene	FOLR1 Gene|FBP|FOLR|FOLR1|Folate Receptor 1 (Adult) Gene|MOv18	The 7-exon (4-7 ORF) human FOLR1 Gene (FOLR Family) encodes 2 alternative isoforms of high affinity Folate Receptor 1, a protein with eight disulfide bonds and attached to the cell membrane by a GPI-anchor that mediates delivery of 5-methyltetrahydrofolate to the cell interior. (NCI)
C39284	Folate_Receptor-1	Cell_Surface_Receptor	Folate Receptor 1|Adult Folate Receptor|Adult Folate-Binding Protein|FBP|FOLR|FOLR1|FR-Alpha|Folate Receptor Alpha|MOv18|Ovarian Tumor-Associated Antigen MOv18	Encoded as 2 alternative isoforms by human FOLR1 Gene (FOLR Family), high affinity Folate Receptor 1 is a protein with eight disulfide bonds and attached to the cell membrane by a GPI-anchor that mediates delivery of 5-methyltetrahydrofolate to the cell interior. (NCI)
C39285	CTAG1_Gene	Gene_with_Unknown_or_Unclassified_Function	CTAG1B Gene|CTAG|CTAG1|CTAG1B|Cancer/Testis Antigen 1B Gene|ESO1|LAGE2B|NY-ESO-1	Expressed in testis and ovary (0.8-kb mRNA), 3-exon 8-kb human CTAG Gene (CTAG Family) encodes 180-aa Cancer/Testis Antigen 1, with 1 putative transmembrane domain. (NCI)
C39286	Cancer-Testis_Antigen-1	Protein_with_Unknown_or_Unclassified_Function	Cancer/Testis Antigen 1|Autoimmunogenic Cancer/Testis Antigen NY-ESO-1|CTAG|CTAG1|CTAG1B|Cancer Antigen 3|Cancer/Testis Antigen 1-B|ESO1|LAGE2B|NY-ESO-1|New York Esophageal Squamous Cell Carcinoma 1	Expressed in testis and ovary by human CTAG Gene (CTAG Family), 180-aa Cancer/Testis Antigen 1 has 1 putative transmembrane domain. (NCI)
C39288	ER_Degradation_Pathway	Degradation_Pathway	Endoplasmic Reticulum Degradation Pathway|ER-associated degradation (ERAD) Pathway
C39289	_20q11_22	Chromosome_Band	20q11.22	A chromosome band present on 20q
C39290	_11q13_3-q14_1	Chromosome_Band	11q13.3-q14.1	A chromosome band present on 11q
C39291	Human_Herpes_Virus_8_Infection	Viral_Infection	Human Herpes Virus 8 Infection
C39292	HTLV-1_Infection	Viral_Infection	HTLV-1 Infection
C39293	Helicobacter_Pylori_Infection	Bacterial_Infection|Gastrointestinal_Infection	Helicobacter Pylori Infection
C39294	Schistosoma_Hematobium_Infection	Schistosomiasis	Schistosoma Hematobium Infection
C39295	Opisthorchis_Viverrini_Infection	Parasitic_Infection	Opisthorchis Viverrini Infection
C39296	HP_Gene	Ligand_Binding_Protein_Gene	HP Gene|HP|Haptoglobin Gene	Expressed in liver, human HP Gene (Peptidase S1 Family) encodes 406-aa 45-kDa (precursor) secreted Haptoglobin, an alpha/beta tetramer (proteolytically processed from a single precursor protein) containing 2 Sushi domains. Binding free plasma hemoglobin, HP prevents loss of iron through the kidneys, protects the kidneys from oxidative damage by hemoglobin, and makes hemoglobin accessible to degradative enzymes. Hp/Hb clearance appears to be mediated by the monocyte/macrophage scavenger receptor CD163. (NCI)
C39297	CGB_Gene	Protein_Complex_Subunit_Gene	CGB Gene|CGB|Chorionic Gonadotropin, Beta Polypeptide Gene	Expressed by placental trophoblasts, human CGB Gene (Glycoprotein Hormone Beta Family) encodes 165-aa 18-kDa (precursor) Chorionic Gonadotropin Beta Subunit, the unique subunit of alpha (common)/beta heterodimeric Chorionic Gonadotropin that confers biological specificity to stimulate ovarian synthesis of steroids that maintain pregnancy. (NCI)
C39298	Adolescence	Conceptual_Entities	Adolescence	Adolescence is the time period between the beginning of puberty and adulthood.
C39299	Pediatric	Patient_Characteristics_Modifier	Pediatric|Childhood|PEDS|pediatric	(pee-dee-AT-rik) Having to do with children.
C39300	Precursor_NK-Cell	Immature_Lymphocyte|T-Lymphocyte_and_Natural_Killer_Cell	Precursor Natural Killer Cell|Precursor NK-Cell
C39301	Neoplastic_Medium-Sized_Natural_Killer_Cell	Neoplastic_Hematopoietic_Cell	CD4+/CD56+ Neoplastic Medium-Sized Cell
C39302	Abramson_Cancer_Center_at_the_University_of_Pennsylvania	Comprehensive_Cancer_Center	Abramson Cancer Center at the University of Pennsylvania	The Abramson Cancer Center at the University of Pennsylvania is an NCI-designated Comprehensive Cancer Center.
C39303	Active_Funded_Research_Project	Research	Active Funded Research Project	The Active Funded Research Project is a project during an active grant funding cycle.
C39304	Agency_for_Healthcare_Research_and_Quality	Other_Agency_or_Organization	Agency for Healthcare Research and Quality|AHCPR|AHRQ|Agency for Health Care Policy and Research	The Agency for Healthcare Research and Quality (AHRQ), a component of the US Department of Health and Human Services, Public Health Service, is the Federal Government's focal point for research of the availability, quality, and costs of health care services; and ways to improve the effectiveness and appropriateness of clinical practice, including the prevention of diseases. AHRQ uses mechanisms of grants, cooperative agreements, and contracts to carry out research projects, demonstrations, evaluations, and knowledge dissemination. Nearly 80 percent of AHRQ's budget is awarded as grants and contracts to researchers at universities and other research institutions across the country. AHRQ was formerly known as the Agency for Health Care Policy and Research (AHCPR).
C39305	Albert_Einstein_Cancer_Center	Comprehensive_Cancer_Center	Albert Einstein Cancer Center|AECC	Albert Einstein Cancer Center is an NCI-designated Comprehensive Cancer Center affiliated with Albert Einstein College of Medicine, and comprised of four basic research and three translational/clinical programs: the Immuno-Oncology Program focused on the genomic instability and the mechanisms underlying survival or death of lymphoid and hematopoietic cells, and mechanisms of immune response to tumor and pathogen antigens; the Signalling, Tumor Cell Motility and Invasion Program investigating biology of hormone/growth factor systems and components and mechanisms of cellular signal transduction, motility and invasion; the Cell Growth and Differentiation Control Program, the Molecular Membrane Biology Program, the Experimental Therapeutics Program, the Cancer Epidemiology Program, and the Colon Cancer Program.
C39306	Alliance_for_Lung_Cancer_Advocacy_Support_and_Education	Other_Agency_or_Organization	Alliance for Lung Cancer Advocacy Support and Education|ALCASE	The Alliance for Lung Cancer Advocacy, Support and Education is a nonprofit organization based in Vancouver, Washington, founded to improve the quality of live of lung cancer patients through raising awareness of issues concerning lung cancer diagnosis and treatment; psychosocial support; and providing education.
C39307	American_Association_for_the_Advancement_of_Science	Professional_Organization_or_Group	American Association for the Advancement of Science|AAAS	The world's largest general non-profit scientific society. It fulfills its mission to 'advance science and serve society' through initiatives in science policy; international programs; science education; and more. AAAS is a publisher of the Science and EurekAlert.
C39308	American_Association_of_Cancer_Research	Professional_Organization_or_Group	American Association of Cancer Research|AACR	Facilitates communication and dissemination of knowledge among scientists and others dedicated to the cancer problem through presentations and discussions of new and improved observations in the field. AACR also fosters research in cancer and related biomedical sciences and promotes public education, science education and training to advance the understanding of cancer etiology, prevention, diagnosis and treatment worldwide. Publishes the journal Cancer Research.
C39309	American_Brain_Tumor_Association	Other_Agency_or_Organization	American Brain Tumor Association|ABTA	The American Brain Tumor Association (ABTA) is a not-profit independent global organization that funds brain tumor research and provides the information patients need to make educated decisions about their health care. ABTA has a special funding program for scientists sponsored by NIH, and sponsors a research study focusing on familial brain tumors.
C39310	American_College_of_Obstetricians_and_Gynecologists	Professional_Organization_or_Group	American College of Obstetricians and Gynecologists|ACOG	A national medical society for obstetricians and gynecologists.
C39311	American_College_of_Oncology_Administrators	Professional_Organization_or_Group	American College of Oncology Administrators|ACOA	A non-profit association for cancer care administrators in the US.  The College focuses on providing educational, funding, peer resources/networking support and opportunity for oncology administrators and managers in all types of healthcare institutions.  Publishes Journal of Oncology Management.
C39312	American_College_of_Physicians	Professional_Organization_or_Group	American College of Physicians|ACP	A national medical society for internal medicine professionals. It publishes 'Annals of Internal Medicine'.
C39313	American_College_of_Radiation_Oncology	Professional_Organization_or_Group	American College of Radiation Oncology|ACRO	A professional society of physicians who limit their practice to radiation oncology, physicians currently enrolled in a fellowship program and radiation oncology physicists in all types of practices. ACRO promotes the education and science of radiation oncology to improve oncologic service, to study the socioeconomic aspects of the practice of radiation oncology, and to encourage improved and continuing education in radiation oncology and its allied professional fields.
C39314	American_College_of_Radiology	Professional_Organization_or_Group	American College of Radiology|ACR	An FDA-designated accrediting body that includes radiologists, radiation oncologists and medical physicists. The ACR focuses its activity on making imaging safe, effective and accessible trough its accreditation programs, research, and development of guidelines for quality imaging, and education.
C39315	American_Joint_Committee_on_Cancer	Professional_Organization_or_Group	American Joint Committee on Cancer|AJCC	A group formed for the purpose of developing a system of clinical staging for cancer that is acceptable to the American medical profession and is compatible with other accepted classifications.
C39316	American_Lung_Association	Other_Agency_or_Organization	American Lung Association	The American Lung Association is a voluntary national health organization funded by contributions from the public, along with gifts and grants from corporations, foundations and government agencies, and dedicated to fight against lung diseases with special emphasis on asthma, tobacco control and environmental health. The Association supports basic and clinical research through training and 'seed' grants for researchers who are at the early stage of their careers.
C39317	American_Medical_Association	Professional_Organization_or_Group	American Medical Association|AMA	A voluntary membership organization of physicians that sets standards for the profession of medicine, and is highly focused on medical education. Publishes JAMA, the Journal of the American Medical Association.
C39318	American_Public_Health_Association	Professional_Organization_or_Group	American Public Health Association|APHA	The oldest and largest organization of public health professionals in the world, representing more than 50,000 members from more than 50 occupations of public health. APHA brings together researchers, health service providers, administrators, teachers, and other health workers, forming multi-disciplinary environment for professional exchange, study, and action. Publishes the American Journal of Public Health.
C39319	American_Society_of_Clinical_Oncology	Professional_Organization_or_Group	American Society of Clinical Oncology|ASCO	The world's leading professional organization representing physicians of all oncology disciplines and subspecialties. ASCO sets the standard for cancer care, supports funding for clinical and translational research, fosters the exchange of information related to cancer, including cancer biology, diagnosis, staging, treatment and psychosocial impact.  ASCO provides training in clinical research and patient care and publishes the Journal of Clinical Oncology.
C39320	American_Society_of_Hematology	Professional_Organization_or_Group	American Society of Hematology|ASH	The world's largest professional society concerned with the causes and treatment of blood disorders. Its mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting the blood, bone marrow, and the immunologic, hemostatic and vascular systems, by promoting research, clinical care, education, training, and advocacy in hematology.
C39321	Analytical_Biochemistry_Shared_Resource	Clinical_or_Research_Facility	Analytical Biochemistry Shared Resource	The Analytical Biochemistry Shared Resource provides chemistry services featuring mass spectrometry, chromatography, organic synthesis, and analytical biochemistry. It serves as a center of expertise for a full range of chemical and biochemical services in support of the cancer research.
C39322	Animal_Models_Service_Shared_Resource	Clinical_or_Research_Facility	Animal Models Service Shared Resource	The Animal Models Service Shared Resource is primarily dedicated to the production, development and characterization of biomedical relevant animal models and species for cancer research including transgenic, knockout, mutant, etc. experimental animal lines. Strains, species and methods are considered according to particular Cancer Center investigators' requirements.
C39323	Animal_Pharmacology_Shared_Resource	Clinical_or_Research_Facility	Animal Pharmacology Shared Resource	Animal Pharmacology Shared Resource provides support and expertise to Cancer Center investigators in evaluation of the pharmacological effects of drug candidates in clinically relevant animal models.
C39324	Association_of_American_Cancer_Institutes	Professional_Organization_or_Group	Association of American Cancer Institutes|AACI	Comprised of 80 of the leading academic and freestanding cancer research centers in the United States.  Almost all of the National Cancer Institute-designated centers are members and the remaining member institutions are academic-based cancer programs that receive NCI support. The AACI's mission combines those of its member institutions and the national cancer program.
C39325	Association_of_American_Medical_Colleges	Professional_Organization_or_Group	Association of American Medical Colleges	A non-profit association of medical schools, teaching hospitals, and academic societies from the US and Canada, working with its members to set a national agenda for medical education, biomedical research, and health care, and assists its members by providing services at the national level that facilitate the accomplishment of their missions.
C39326	Association_of_Community_Cancer_Centers	Professional_Organization_or_Group	Association of Community Cancer Centers|ACCC	A non-NCI-affiliated cancer accreditated network. ACCC Institution/Group Practice members include more than 650 medical centers, hospitals, oncology practices, cancer programs, state oncology societies, physician groups, medical and radiation oncologists, and others associated with cancer care across the US. This group of organizations sees more than 40 percent of all new cancer patients in the United States each year.
C39327	Bachelor_s_Degree	Academic_Degree	Bachelor's Degree|Baccalaureate Degree	Bachelor's degree is an award (baccalaureate or equivalent degree, as determined by the Secretary of the U.S. Department of Education) conferred by a college, university, or other postsecondary education institution as official recognition for the successful completion of a program of studies, that normally requires at least four years of full-time equivalent college-level work. This includes bachelor's degrees conferred in a five-year cooperative program.
C39328	Barbara_Ann_Karmano_Cancer_Institute	Comprehensive_Cancer_Center	Barbara Ann Karmano Cancer Institute|The Cancer Center of Metropolitan Detroit|The Meyer L. Prentis Comprehensive Cancer Center Of Metropolitan Detroit	Barbara Ann Karmanos Cancer Institute - the Meyer L. Prentis Cancer Center of Metropolitan Detroit was awarded comprehensive status by the National Cancer Institute in 1978. The research programs are: Breast Cancer Program, Developmental Therapeutics Program, Molecular Biology and Human Genetics Program, Population studies and Prevention Program, and Proteases and Cancer program.
C39329	Barrier_Animal_Facility_Shared_Resource	Clinical_or_Research_Facility	Barrier Animal Facility Shared Resource	The Animal Barrier Shared Resource provides for acquisition and maintenance of both pathogen-free and infected laboratory animals, including immunodeficient strains, while permitting supervised access for investigators, stable husbandry conditions, and individualized daily health care for animals. The Resource implements methods that allow maximal retention of animals when an infectious agent is detected in a barrier room. These include static microisolator housing, handling animals with disinfected forceps, opening animal cages only in a hood, cage-by-cage testing and requiring that full barrier garb be worn by all persons entering animal rooms.
C39330	Bioinformatics_Shared_Resource	Clinical_or_Research_Facility	Bioinformatics Shared Resource	The Bioinformatics Shared Resource provides Cancer Center investigators with the infrastructure and guidance in the following areas: genomic data analysis, microarray data analysis, protein structure and molecular modeling, computational tools, database mining, development, and support, and training for user community.
C39331	Biosafety_Service_Shared_Resource	Clinical_or_Research_Facility	Biosafety Service Shared Resource|Biohazard Shared Resource	The Biosafety Service Shared Resource provides technical guidance and training in biological safety issues for members of Cancer Center including biological agents handling, registration of recombinant DNA and infectious agents, handling of human materials and potentially infectious materials, decontamination and disposal of biological waste, use of biosafety equipment, clean-up of biological spills. Resource assists in facilities design, advices during the construction of containment facilities, and maintains a liaison with governmental agencies regarding biosafety related matters.
C39332	Biostatistics_Shared_Resource	Clinical_or_Research_Facility	Biostatistics Shared Resource	The Biostatistics Shared Resource works with Cancer Center investigators to define study/protocol objectives and endpoints, analyze pilot data, select an appropriate study design, blinding methods and randomization scheme, plan interim analyses, define an adequate sample size and accrual rate, develop and evaluate the statistical methods and analyse data, prepare statistical sections of the grant and protocol applications, analyze and design relational databases, forms and reports.
C39333	Board_of_Scientific_Advisors_NCI	NCI_Advisory_Boards_and_Groups	Board of Scientific Advisors NCI|BSA|NCI Board of Scientific Advisors	The NCI Board of Scientific Advisors, comprised of leading scientists and members of lay community, advises the Director and Deputy Director for Extramural Science, and the Director of each NCI Division on matters concerning scientific program policy, progress and future direction of extramural research programs. The advisory role of the Board is scientific and does not include deliberation on matters of public policy.
C39334	California_Breast_Cancer_Research_Program	Funding_Opportunities	California Breast Cancer Research Program|CBCRP	The California Breast Cancer Research Program (CBCRP) is a program established pursuant to passage by the California Legislature of the 1993 Breast Cancer Act and responsible for administering funding for breast cancer research in the State of California. The mission of the CBCRP is to eliminate breast cancer by leading innovation in research, communication, and collaboration in the California scientific and lay communities.
C39335	Cancer_Center_at_Cold_Spring_Harbor_Laboratory	Cancer_Center	Cancer Center at Cold Spring Harbor Laboratory|CSHL Cancer Center	The Cancer Center at Cold Spring Harbor Laboratory has been designated as an NCI Basic Cancer Center since 1987. It is organized into three research programs (The Gene Expression Program, The Cell Biology Program, The Cancer Genetics Program), and twelve shared resources.
C39336	Cancer_Center_at_the_Burnham_Institute	Cancer_Center	Cancer Center at the Burnham Institute	The Cancer Center at The Burnham Institute represents one from eight basic science Cancer Centers sponsored by the NCI. Center received NCI designation in 1981. Major research topics include: strategies for preventing tumor metastasis, methods for blocking tumor angiogenesis, strategies for triggering apoptosis, study of mechanisms of chemoresistance and radioresistance, use of natural products in cancer prevention, and technologies for tumor-targeted therapy.
C39337	Cancer_Center_at_the_Salk_Institute_for_Biological_Studies	Cancer_Center	Cancer Center at the Salk Institute for Biological Studies	Cancer Center was established at the Salk Institute in 1970. The center includes 22 faculty members, 150 postdoctoral researchers, 45 graduate students and 80 research assistants. It comprises about half of the research at the Salk Institute. Major areas of research focus within three areas: molecular biology and genetics, growth control, and cell and developmental biology.
C39338	Cancer_Center_of_University_of_California_Irvine	Comprehensive_Cancer_Center	Cancer Center of University of California Irvine|Chao Family Comprehensive Cancer Center of University of California Irvine	The Cancer Center of University of California, Irvine was awarded with comprehensive cancer center status in 1997.
C39339	Cancer_Center_Organizational_Capabilities_Section_of_Cancer_Center_Support_Grant_Application	Grants_Preparing_Applications	Cancer Center Organizational Capabilities Section of Cancer Center Support Grant Application	The Cancer Center Organizational Capabilities section of the Cancer Center Support Grant Application Form PHS 398 is a part of application describing a cancer center's programmatic structure, administrative organization, advisory groups and decision-making committees and processes.
C39340	Cancer_Center_Planning_Grant	Extramural_Funding_Mechanisms	Cancer Center Planning Grant|P20 Grant	The Cancer Center Planning Grant (P20) is an NCI-provided grant available to research organizations interested in developing an NCI-designated Cancer Center. P20 Grant can be awarded for a maximum of 3 years of support. The applicant must identify the cancer center concept to be promoted within its institution, research objectives for the center, and ensure research goals are translated into improved patient care, cancer prevention and control, education programs, and community information services. At the end of the P20 grant cycle, the organization should be prepared to submit a CCSG application.
C39341	Cancer_Center_Support_Grant_Application	Grants_Preparing_Applications	Cancer Center Support Grant Application	The CCGA application (Form PHS-398) requests documentation on the qualifications of the principal investigators and associates, pertinent budget information and justification for the support of this proposed grant. Up to 5 years of support may be requested. Grants are funded based on scientific merit, program relevance, and program balance and are made annually.
C39342	Cancer_Clinical_and_Economic_Outcomes_Shared_Resource	Clinical_or_Research_Facility	Cancer Clinical and Economic Outcomes Shared Resource	The Cancer Clinical and Economic Outcomes Shared Resource is a multi-disciplinary resource providing methodologic expertise and support for Cancer Center investigators in patient-centered evaluation in patients at risk for or with cancer. The main areas of support include: cost and cost-effectiveness analyses of programs and initiatives, quality of life and functional status assessment, psychosocial outcome and satisfaction evaluation, survey design and research, and simulation modeling.
C39343	Cancer_Institute_at_Oregon_Health_and_Science_University	Clinical_Cancer_Center	Cancer Institute at Oregon Health and Science University|The OHSU Cancer Institute	The Cancer Institute at Oregon Health and Science University was designated as a Clinical Cancer Center by the NCI in 1997. The Institute explores cancer-related issues with five research programs, each interfacing with clinical care: the Cancer Biology Program, the Hematologic Malignancies Program, the Hormonal and Reproductive Cancers Program, the Gastrointestinal Malignancies Program, the Cancer Prevention and Control Program, The Institute provides eight shared resources for the use of its members.
C39344	Cancer_Institute_of_New_Jersey	Comprehensive_Cancer_Center	Cancer Institute of New Jersey|CINJ	The Cancer Institute of New Jersey is an NCI-designated Comprehensive Cancer Center affiliated with the Robert Wood Johnson Medical School. It includes a network of 20 affiliated hospitals, houses several specialized centers including the Dean and Betty Gallo Prostate Cancer Center, the LIFE Center for Breast Cancer Awareness, the Fannie E. Rippel Foundation Center for Women's Reproductive Cancers, and the Center for the Study of Diet and Nutrition. Major research programs are: Cancer Pharmacology Program, Clinical Investigations Program, Cancer Control Program, Pediatric Oncology Program
C39345	Cancer_Patient_Education_Network	Other_Agency_or_Organization	Cancer Patient Education Network|CPEN	The Cancer Patient Education Network is an NCI-sponsored organization of cancer patient education leaders from NCI-designated comprehensive and clinical centers nationwide.
C39346	Cancer_Prevention_Biomarker_and_Genotyping_Shared_Resource	Clinical_or_Research_Facility	Cancer Prevention Biomarker and Genotyping Shared Resource	The Cancer Prevention Biomarker and Genotyping Resource provides Cancer Center investigators with support in genotyping and biomarker assays to evaluate markers of disease susceptibility and therapeutic response including biochemical and immunological assays to detect or quantitate cellular proteins, hormones, or metabolites, polymorphism panels that include genes that are of highest interest in cancer prevention and treatment, i.e., DNA repair, detoxification, immunoregulation and viral clearance, steroidogenesis, cell cycle regulation, and drug metabolism; and appropriate sample collection, storage, and handling for genotyping or biomarker analysis, as well as consultation on testing and markers information.
C39347	Cancer_Research_and_Prevention_Foundation	Other_Agency_or_Organization	Cancer Research and Prevention Foundation|CRPF	The Cancer Research and Prevention Foundation is a national, non-profit health foundation whose mission is declared as the prevention and early detection of cancer through scientific research and education. The Foundation's expenses fall into two categories: research and education grants that are awarded to institutions, individuals and organizations, and are selected through a grant-review process approved by the National Institutes of Health.
C39348	Cancer_Research_Center_of_Hawaii	Clinical_Cancer_Center	Cancer Research Center of Hawaii|CRCH	The Cancer Research Center of Hawaii is a research unit of the University of Hawaii. It became an NCI-designated Clinical Cancer Center in 1996.
C39349	Cancer_Treatment_Research_Foundation	Other_Agency_or_Organization	Cancer Treatment Research Foundation|CTRF	The Cancer Treatment Research Foundation (CTRF) is a non-profit organization committed to the eradication of cancer by providing the most innovative and promising patient-driven clinical research that delivers immediate treatment options. CTRF stimulates and funds research relevant to cancer therapy (e.g., new agents, immunotherapy, biological response modifiers, gene therapy), clinical nutrition, quality of life and cancer integrative medicine.
C39350	Center_for_Cancer_Research_at_the_Massachusetts_Institute_of_Technology	Cancer_Center	Center for Cancer Research at the Massachusetts Institute of Technology|CCR at MIT	The Center for Cancer Research at the Massachusetts Institute of Technology is an NCI-designated Cancer Center. Areas of research include cancer molecular biology, genetics, cell biology and immunology.
C39351	CHAI_Foundation	Other_Agency_or_Organization	CHAI Foundation	CHAI Foundation is a 501(C)(3) non-profit organization formed to fund biomedical research into promising avenues largely ignored because they do not conform to current group-think. CHAI Foundation finds and funds credentialed researchers who are under funded because their theories do not fit into the mold of current group-think or who are overlooked in favor of younger researchers.
C39352	Children_s_Cancer_Group	Clinical_Trials_Cooperative_Group	Children's Cancer Group|CCG	An NCI-supported clinical cooperative group dedicated to conduct clinical research on childhood cancer, in 2001 was merged with the National Wilms Tumor Study Group, the Pediatric Oncology Group and the Intergroup Rhabdomyosarcoma Study Group to form a new national organization, the Children's Oncology Group.
C39353	Children_s_Oncology_Group	Clinical_Trials_Cooperative_Group	Children's Oncology Group|COG	An NCI-supported clinical cooperative group formed by the merger of the four national pediatric cancer research organizations: the Children's Cancer Group, the Intergroup Rhabdomyosarcoma Study Group, the National Wilms Tumor Study Group, and the Pediatric Oncology Group. The primary objective of the organization is to conduct clinical trials of new therapies for childhood and adolescent cancer. COG develops and coordinates clinical trials conducted at the 238 member institutions that include cancer centers of all major universities and teaching hospitals throughout the U.S. and Canada, as well as sites in Europe and Australia. COG members include over 5000 cancer researchers.
C39354	Chromatography_Shared_Resource	Clinical_or_Research_Facility	Chromatography Shared Resource	Chromatography Shared Resource provides Cancer Center investigators with support in the development of chromatography-based analytical methods and scanning calorimetry in studies of cancer and drug development.
C39355	City_of_Hope_Comprehensive_Cancer_Center	Comprehensive_Cancer_Center	City of Hope Comprehensive Cancer Center	City of Hope Comprehensive Cancer Center was designated a Comprehensive Cancer Center by NCI in 1998. This facility is located in Duarte, California, with high percentage of beds devoted to bone marrow transplantation patients. The center is a founding member of the National Comprehensive Cancer Network. It has two basic science research programs: Genetic, Epigenetic, and Post-Transcriptional Regulation Program and Program in DNA Damage and Repair, three clinical programs: Hematologic Malignancy Program, Clinical and Experimental Therapeutics Program, Cancer Immunotherapeutics Program (Radioimmunotherapy, Cellular Immunotherapy, Molecular Immunotherapeutics), and advanced Clinical, Genetic, and Psychosocial Determinants of Cancer Risk and Outcomes Program.
C39356	Clinical_Informatics_Shared_Resource	Clinical_or_Research_Facility	Clinical Informatics Shared Resource	The Clinical Informatics Shared Resource provides database and application support to the clinical research programs in Cancer Center including overall informatics support for clinical operations, patient registry services, development of clinical trials management applications, laboratory information management applications, privacy protection components necessary to maintain HIPAA-compliant research information services, storage, archival and other informatics services.
C39357	Clinical_Pathway	Clinical_or_Research_Activity	Clinical Pathway	Clinical Pathway is a defined set of diagnostic tests, treatments, and other interventions (including palliative care) for different types and stages of cancer.
C39358	Clinical_Protocol_Date_Closed_Standard_Cancer_Center_Information_Summary	Grants_Preparing_Applications	Clinical Protocol Date Closed Standard Cancer Center Information Summary	The Clinical Protocol Date Closed, Standard Cancer Center Information Summary for Cancer Center Support Grant Application, is the date when the clinical study was closed to accrual at the reporting Cancer Center during the 12-month reporting period.
C39359	Clinical_Protocol_Date_Opened_Standard_Cancer_Center_Information_Summary	Grants_Preparing_Applications	Clinical Protocol Date Opened Standard Cancer Center Information Summary	The Clinical Protocol Date Opened, Standard Cancer Center Information Summary for Cancer Center Support Grant Application, is the date when the clinical study was opened to accrual at the reporting Cancer Center.
C39360	Clinical_Research_Support_Shared_Resource	Clinical_or_Research_Facility	Clinical Research Support Shared Resource	The Clinical Research Shared Resource provides Cancer Center investigators with assistance in identification of prospective patients and determination of patient interest and eligibility to participate in clinical trials, in procurement and maintenance of the informed consent process, coordination of follow-up visits in conformance with protocol, hospital admission and discharge planning, coordination and safe administration of investigational agents, toxicity monitoring and reporting in compliance within Cancer Center and FDA regulations and the guidelines of GCP.
C39361	Clinical_Trials_Protocol_and_Data_Management_Shared_Resource	Clinical_or_Research_Facility	Clinical Trials Protocol and Data Management Shared Resource	The Clinical Trials Protocol and Data Management Shared Resource provides administrative support for Clinical Trials: assistance with protocol and budget development, submission and maintenance of IRB documentation, transmission of required information to study sponsors and federal oversight agencies, coordination of IRB approval, protocol conduct and data collection with affiliated institutions, data retrieval and data transcription in compliance within the guidelines of GCP, quality assurance to ensure completeness and accuracy of data, maintenance of protocol and patient registration system, protocol monitoring and generation of reports, hiring/training of data managers, contract development and management.
C39362	Clinical_Trials_Scientific_Review_and_Monitoring_System	Clinical_or_Research_Facility	Clinical Trials Scientific Review and Monitoring System	The Clinical Trials Scientific Review and Monitoring system is the system required by all NCI-designated cancer centers to stringently select for high quality research and to regularly monitor ongoing research for continued access to core grant resources.
C39363	Cloning_Laboratory_Shared_Resource	Clinical_or_Research_Facility	Cloning Laboratory Shared Resource	The Cloning Laboratory Shared Resource provides restriction enzymes, DNA and RNA modification enzymes, host cell lines, kits, cloning and expression vectors, competent cells, molecular weight markers, and other chemicals and reagents for Cancer Center research projects in the fields of molecular biology and biochemistry.
C39364	Common_Scientific_Outline_NCI	Cancer_Science	Common Scientific Outline NCI|CSO	The NCI Common Scientific Outline (CSO) is a classification system organized around seven broad areas of scientific interest in cancer research to lay the framework for better coordination among research organizations and funding agencies: cancer biology; cancer etiology; cancer prevention; cancer early detection, diagnosis, and prognosis; cancer treatment; cancer control, survivorship, and outcomes research; and scientific model systems. The NCI research portfolio is organized around the CSO categories.
C39365	Community_Trial	Research	Community Trial	The Community Trial is a planned experiment that involves administering an exposure within a community in order to elucidate its impact on the incidence of a specific disease in that community. The community trial is a choice when exposure cannot be prevented among control group.
C39366	Comprehensive_Cancer_Center_at_the_University_of_Arizona_Health_Sciences_Center_in_Tucson	Comprehensive_Cancer_Center	Comprehensive Cancer Center at the University of Arizona Health Sciences Center in Tucson	Comprehensive status was granted to the Center by the NCI in 1990. Comprehensive Cancer Center at The University of Arizona incorporates six programs: Therapeutic Development Program, Cancer Center Imaging and Technology Program, Cancer Metastasis and Signaling Program, Cancer Prevention and Control Program, Gastrointestinal Cancer Program, Molecular Genetics Program.
C39367	Comprehensive_Cancer_Center_of_Wake_Forest_University	Comprehensive_Cancer_Center	Comprehensive Cancer Center of Wake Forest University|CCCWFU	Major areas of research: mechanisms of cell growth and survival, DNA damage and cell defense, cancer control. The Center has an extensive Clinical Research Program and is a home for inter-programmatic Breast Cancer Center of Excellence and Prostate Cancer Center of Excellence.
C39368	Computer_Retrieval_of_Information_on_Scientific_Projects_Database	Data_Sources	Computer Retrieval of Information on Scientific Projects Database|CRISP	The Computer Retrieval of Information on Scientific Projects Database (CRISP) is a searchable database of federally funded biomedical research projects maintained by the Office of Extramural Research at NIH. It includes projects funded by NIH, Substance Abuse and Mental Health Services Administration, Health Resources and Services Administration, Food and Drug Administration, Centers for Disease Control and Prevention, Agency for Healthcare Research and Quality, and Office of Assistant Secretary of Health.
C39369	Computer_Service_Shared_Resource	Clinical_or_Research_Facility	Computer Service Shared Resource	The Computer Service Shared Resource provides Cancer Center members with the technical support related to computer issues: desktop computer assistance, upgrades, hardware and software related problems, problems maintenance of file/mail/Internet servers, security and backup systems, computer purchase assistance, network topology, operations management, data base administration, Web site development.
C39370	Consolidated_Budget_Request_of_Cancer_Center_Support_Grant_Application	Grants_Preparing_Applications	Consolidated Budget Request|Consolidated Budget Request of Cancer Center Support Grant Application	The Consolidated Budget Request is a part of the Cancer Center Support Grant Application Form PHS 398. It reflects requested budget for the first 12-month period and the summary budget for the entire proposed budget period.
C39371	Cure_for_Lymphoma_Foundation	Other_Agency_or_Organization	Cure for Lymphoma Foundation|CFL	The Cure For Lymphoma Foundation (CFL) is a nationwide not-for-profit organization dedicated to funding research and providing support and education for Hodgkins disease and non-Hodgkins lymphoma patients and their families.
C39372	Cytogenetics_Shared_Resource	Clinical_or_Research_Facility	Cytogenetics Shared Resource	Cytogenetics Shared Resource provides Cancer Center members with support in following areas: routine cytogenetic (such as giemsa (G)-banding on fibroblast, lymphoblast or somatic cell hybrid lines to determine karyotypes, etc.), fluorescence in situ hybridization (FISH) for clarification of karyotypes, and SKY (spectral karyotyping), to analyze chromosomal changes, microsatellite analysis of tumors for loss of heterozygosity, mutation analysis of tumors, chimerism studies of bone marrow transplants; maintenance of cell lines and lymphocytes.
C39373	Damon_Runyon_Cancer_Research_Foundation	Other_Agency_or_Organization	Damon Runyon Cancer Research Foundation	The Damon Runyon Cancer Research Foundation is a non-profit organization dedicated to advancing cancer research. It encourages extraordinary young scientists to pursue careers in cancer research by funding initial postdoctoral Fellowship Awards, Scholar Awards and Clinical Investigator Awards.
C39374	Dana-Farber_Cancer_Institute	Comprehensive_Cancer_Center	Dana-Farber Cancer Institute|DF/HCC	The Dana-Farber Cancer Institute is a founding member of the Dana-Farber/Harvard Cancer Center, a federally designated Comprehensive Cancer Center, a principal teaching affiliate of Harvard Medical School, and a federally designated Center for AIDS Research.
C39375	Data_Compilation_and_Analysis_Shared_Resource	Clinical_or_Research_Facility	Data Compilation and Analysis Shared Resource	The Data Compilation and Analysis Shared Resource provides Cancer Center investigators with design and programming of relational databases for clinical, population and other large-scale studies, development and supervision of a sophisticated data communication and reporting systems, software development for analyzing and interpreting data generated from clinical trials, population studies, microarray and proteomics technologies and other types of translational research.
C39376	Digital_Imaging_Shared_Resource	Clinical_or_Research_Facility	Digital Imaging Shared Resource	The Digital Imaging Shared Resource provides Cancer Center investigators with support in high-resolution deconvolution microscopy, digital epi-fluorescence and brightfield microscopy, quantitative image analysis, cell microinjection and resulting biological analyses, and photo-production.
C39377	Director_of_Cancer_Research_Center	Research_Personnel	Director of Cancer Research Center|Cancer Center Director	The Director of Cancer Research Center is professional, administrative, research and academic position with Cancer Center. The incumbent is responsible for the overall direction in the conduct of cancer and allied research; provision and coordination of training in cancer-related research and education; operations, staffing, and maintenance of research facilities; development of new research activities; developing and maintaining relationships with other cancer centers in the nation as well as with international scientific community.'
C39378	DNA_RNA_and_Peptide_Synthesis_Shared_Resource	Clinical_or_Research_Facility	DNA RNA and Peptide Synthesis Shared Resource	DNA, RNA and Peptide Synthesis Laboratories provide support to researchers regarding oligonucleotide and peptide chemistry. Primary services of this facility include: synthesis of DNA, RNA, chimeric DNA/RNA molecules, and custom oligonucleotides, including those containing modified bases, modified sugars, and incorporated labels and linkers, and synthesis of various types of peptides.
C39379	DNA_Sequencing_Shared_Resource	Clinical_or_Research_Facility	DNA'sequencing Shared Resource	The DNA Sequencing Shared Resource offers automated DNA sequencing for Cancer Center investigators. The resource provides sequence assembly services such as plasmid, PCR product, lambda, cosmid, PAC, BAC DNA templates sequencing, and consultation services and protocols for designing sequencing strategies and for the preparation of substrates.
C39380	Doctor_of_Chiropractic	Doctor_s_Degree	Doctor of Chiropractic|Chiropractic Physician|D.C.|D.C.M.|DC|DCM	The Doctor of Chiropractic degree is a degree awarded for graduates who have completed a medical doctoral program in accredited chiropractic college. The academic and clinical training include, but are not limited to, the use of current diagnostic and therapeutic procedures that specifically involve the adjustment and manipulation of the articulations and adjacent tissues of the human body, particularly of the spinal column. State laws, as well as the nation's antitrust laws, may allow Doctors of Chiropractic to utilize ancillary health care procedures commonly referred to as being in the common domain.
C39381	Doctor_of_Dental_Medicine	Doctor_s_Degree	Doctor of Dental Medicine|D.M.D.|DMD	The Doctor of Dental Medicine degree is the first-professional, postgraduate degree awarded for graduates who have completed a program of studies in dental medical science. The academic standard is equivalent to Ph.D.
C39382	Doctor_of_Dental_Surgery	Doctor_s_Degree	Doctor of Dental Surgery|D.D.S.|DDS	The Doctor of Dental Surgery degree is the first-professional, postgraduate degree awarded for graduates who have completed a program of studies in dental surgery.
C39383	Doctor_of_Medicine	Doctor_s_Degree	Doctor of Medicine|M.D.|MD	The Doctor of Medicine degree is the first-professional postgraduate degree that requires completion of a program that meets all of the following criteria: completion of the academic requirements to begin practice in the profession; at least 2 years of college work prior to entering the program; and a total of at least 6 academic years of college work to complete a program of studies in any branch of medical science, including prior required college work plus the length of the professional program itself. The academic standard is equivalent to Ph.D. science.
C39384	Doctor_of_Optometry	Doctor_s_Degree	Doctor of Optometry|OD	The Doctor of Optometry degree is the first-professional, postgraduate degree awarded to the graduates who have completed a specialized four year post-baccalaureate professional program in order to become independent health care providers who examine, diagnose, treat, and manage disorders of the visual systems and diseases of the eye and associated structures.
C39385	Doctor_of_Osteopathic_Medicine	Doctor_s_Degree	Doctor of Osteopathic Medicine|D.O.|DO	The Doctor of Osteopathic Medicine degree is the first-professional, postgraduate degree awarded to the graduates who have completed an osteopathic medicine program which is designed to prepare physicians who are especially concerned with maintaining continuing personal relationships with patients, their families and their optimum interaction with the community environmental patterns.
C39386	Doctor_of_Pharmacy	Doctor_s_Degree	Doctor of Pharmacy|Pharm.D.|PharmD	The Doctor of Pharmacy degree is the postgraduate, first-professional degree that requires completion of a program in pharmacy that meets all of the following criteria: completion of the academic requirements to begin practice in the profession; at least 2 years of college work prior to entering the program; eight academic semesters after admission to the School of Pharmacy and involves extensive instruction in professional pharmacy pre-clinical and clinical sciences.
C39387	Doctor_of_Philosophy	Doctor_s_Degree	Doctor of Philosophy|Ph.D.|PhD	The Doctor of Philosophy degree is the highest academic degree awarded in recognition of creative scholarship and research in a field of study. The recipient of this degree must have demonstrated proficiency in a broad area of learning and the ability to critically evaluate work in the discipline. The degree is not awarded solely for completing a prescribed number of courses, but for having undertaken and completed independent work in the discipline leading to an original contribution to knowledge.
C39388	Doctor_of_Philosophy_in_Human_Services	Doctor_of_Philosophy	Doctor of Philosophy in Human Services|Ph.D. in Human Services|PhD in Human Services	The Doctor of Philosophy in Human Services is a postgraduate degree in areas of specialization addressing social challenges within the health care field.
C39389	Doctor_of_Podiatric_Medicine	Doctor_s_Degree	Doctor of Podiatric Medicine|D.P.|D.P.M.|DP|DPM|Pod.D.|PodD	The Doctor of Podiatric Medicine degree is the first-professional, postgraduate degree awarded to the graduates who have completed an podiatric medicine program which is designed to prepare physicians who prevent, diagnose, and treat diseases and disorders that affect the human foot and ankle.
C39390	Doctor_of_Public_Health	Doctor_s_Degree	Doctor of Public Health|Dr.P.H.	Doctor of Public Health is an academic degree in public health. The prior degree is generally earned in the closely related professional field, e.g. medicine.
C39391	Doctor_of_Veterinary_Medicine	Doctor_s_Degree	Doctor of Veterinary Medicine|D.V.M.|DVM	The Doctor of Veterinary Medicine degree is a postgraduate first-professional degree awarded for graduates who have completed a program of studies in veterinary medicine.
C39392	Doctor_s_Degree	Academic_Degree	Doctor's Degree|Doctorate Degree	The Doctor's Degree is the highest award a student can earn for graduate study. The doctor's degree classification includes such degrees in any field.
C39393	Duke_Comprehensive_Cancer_Center	Comprehensive_Cancer_Center	Duke Comprehensive Cancer Center	The Duke Comprehensive Cancer Center received NCI-designated status in 1973. The Center has established programs in basic research (Cell Regulation and Transmembrane Signaling, Nucleic Acid Biology and Chemistry, Cellular and Structural Biology, and Molecular Oncology and Cancer Genetics); basic and translational research (Cancer Immunobiology, Radiation Oncology/Hyperthermia Research, Neuro-Oncology, Experimental Therapeutics); clinical and population research (Bone Marrow Transplantation, Breast and Ovarian Oncology, Cancer Prevention, Detection and Control Research).
C39394	Electron_Microscopy_Shared_Resource	Clinical_or_Research_Facility	Electron Microscopy Shared Resource	The Electron Microscopy Shared Resource provides the following services to Cancer Center researchers: counseling on the appropriate electron microscopy method for particular project, sample preparation and ultrastructural analysis by conventional electron microscopy, photographic and digital documentation of the samples, analysis and interpretation of the results, preparation of presentation-quality images.
C39395	Epidemiology_and_Cancer_Control_Shared_Resource	Clinical_or_Research_Facility	Epidemiology and Cancer Control Shared Resource	The Epidemiology and Cancer Control Shared Resource provides consultation and support to the Cancer Center investigators conducting research projects related to cancer epidemiology and control, health behavior and quality of life research, and molecular and clinical oncology. Areas of support are, but not limited to: study design, data collection, quality control and analysis, software and measurement error models development, statistical programming, and interpretation and dissemination of results.
C39397	Experimental_Pathology_and_Histopathology_Shared_Resource	Clinical_or_Research_Facility	Experimental Pathology and Histopathology Shared Resource	The Experimental Pathology and Histopathology Shared Resource provides Cancer Center investigators with support in the histopathology services including animal necropsies, routine and special histological preparations, histopathologic evaluation, and assistance in experimental design.
C39398	Experimental_Pathology_Shared_Resource	Clinical_or_Research_Facility	Experimental Pathology Shared Resource	The Experimental Pathology Shared Service provides Cancer Center investigators with access to histotechnology and pathology services including but not limited to routine histologic evaluation, enzyme histochemistry, immunohistochemistry, in situ hybridization, and autoradiography for diagnosis or characterization of tissue sections obtained from animal models.
C39399	Externally_Peer-Reviewed_Trial_Standard_Cancer_Center_Information_Summary	Grants_Preparing_Applications	Externally Peer-Reviewed Trial Standard Cancer Center Information Summary	The Externally Peer-Reviewed Trial, Standard Cancer Center Information Summary for Cancer Center Support Grant Application, is R01s and P01s study funded by NIH or trial supported by other peer-reviewed funding organization.
C39400	Familial_Cancer_Risk_Shared_Resource	Clinical_or_Research_Facility	Familial Cancer Risk Shared Resource	Fellow of American College of Surgeons is a member of a society of surgical medicine practitioners.  Reflects education and training, professional qualifications, surgical competence, and ethical conduct consistent with standards established by the College.
C39401	Fellow_of_American_College_of_Physicians	Training_and_Education	Fellow of American College of Physicians|FASP	The Familial Cancer Risk Shared Resource provides Cancer Center investigators with clinical genetic expertise, data on familial genetic syndromes, germline mutations and cancer modifier genes; access to a database of genotyped probands with hereditary cancers; and clinical specimens with correlative epidemiologic data from subjects with genetically verified hereditary cancer.
C39402	Fellow_of_American_College_of_Surgeons	Training_and_Education	Fellow of American College of'surgeons|FACS	Fellow of American College of Physicians is a member of society of internal medicine practitioners. Reflects education and training, professional qualifications and competence, and ethical conduct consistent with standards established by the College.
C39403	Fermentation_Shared_Resource	Clinical_or_Research_Facility	Fermentation Shared Resource	The Fermentation Shared Resource provides services for custom production, purification, and maintenance of microorganisms, microbial products, and other plant and animal cells for use in cancer research by Cancer Center investigators.
C39404	Field_Survey	Population_Study	Field Survey	A descriptive or analytic study of risk factors or disease determinants in populations. Most epidemiologic and some genetic studies fit within this category.
C39405	Flow_Cytometry_Shared_Resource	Clinical_or_Research_Facility	Flow Cytometry Shared Resource	The Flow Cytometry Shared Resource provides Cancer Center investigators with following support: analytical flow cytometry, sorting of cell subpopulations utilizing various criteria, such as intrinsic cell properties, e.g. DNA content, Green Fluorescent Protein, or extrinsic properties, such as molecular markers identified by fluorescently-labelled monoclonal antibodies, automated magnetic cell sorting. The resource operates, maintains, and upgrades instrumentation for flow cytometric analysis and cell sorting, advises in the design of experiments and contributes consultation in analysis of data.
C39406	Fly_Facility_Shared_Resource	Clinical_or_Research_Facility	Fly Facility Shared Resource	The Fly Facility Shared Resource provides housing for collection of the standard wild type and mutant strains of Drosophila melanogaster and all services related to maintenance of fly stocks.
C39407	Fox_Chase_Cancer_Center	Comprehensive_Cancer_Center	Fox Chase Cancer Center	The Fox Chase Cancer Center is an NCI-designated Comprehensive Cancer Center. Current faculty research programs include: the Breast Cancer Research Program, the Cellular and Developmental Biology Program, the Developmental Therapeutics Program, the Drug and Radiation Resistance Program, the Human Genetics Program, the Immunobiology Program, the Molecular Epidemiology Program, the Prostate Cancer Research Program, the Tumor Cell Biology Program, the Virology Program, the Ovarian Cancer Program, and NCI SPORE in prevention, diagnosis and treatment of ovarian cancer.
C39408	Fred_Hutchinson_Cancer_Research_Center	Comprehensive_Cancer_Center	Fred Hutchinson Cancer Research Center	The Fred Hutchinson Cancer Research Center is an NCI-designated Comprehensive Cancer Center. Scientific research is organized into following programs: Basic Sciences Program, Biostatistics Program, Breast Cancer Research Program, Cancer Biology, Cancer Prevention Research Program, Clinical Transplant Research Program, Epidemiology Program, Genetics, Genome Instability, Gynecologic Cancer Program, Human Biology Program, Human Immunogenetics Program, Immunology Program, Infectious Diseases Program, Molecular Imaging, Pediatric Oncology Program, Prostate Cancer Research Program, Transplantation Biology Program.
C39409	Funding_Agency	Professional_Organization_or_Group	Funding Agency|Funding Source	An organization that has funds for the projects of particular type, processes applications for funding, and awards funds to qualified applicants.
C39410	Gene_Therapy_and_Vector_Shared_Resource	Clinical_or_Research_Facility	Gene Therapy and Vector Shared Resource	The Gene Therapy and Vector Shared Resource is dedicated to the construction and production of viral and non-viral vectors to Cancer Center faculty members for use in human preclinical and clinical, and animal gene therapy studies, supports protocol development, study strategy development, and gene therapy adverse event risk assessment.
C39411	General_and_Equipment_Repair_Shared_Resource	Clinical_or_Research_Facility	General and Equipment Repair Shared Resource	The General and Equipment Repair Shared Resource provides biomedical and laboratory equipment management, maintenance, repair, and engineering support services for Cancer Center departments and laboratories.
C39412	Genomics_and_Proteomics_Shared_Resource	Clinical_or_Research_Facility	Genomics and Proteomics Shared Resource	The Genomics and Proteomics Shared Resource is an integrated resource that provides genomic and proteomic technologies to the Cancer Center investigators for basic and clinical research applications including DNA and RNA isolation, DNA sequencing, serial analysis of gene expression library production, SNP genotyping, STRP genotyping, microarray analysis, quantitative RT-PCR, protein identification and sequencing and profiling.
C39413	Genomics_Shared_Resource	Clinical_or_Research_Facility	Genomics Shared Resource	The Genomics Shared Resource provides Cancer Center researchers with support in areas of genetic and molecular biological analysis including DNA, RNA isolation, custom genotyping of structural genes, regulatory sequences, and non-coding segments, gene expression assays, library manipulation and construction, fluorescence in situ hybridization, and consultation services related to the above.
C39414	Glasswashing_and_Sterilization_Shared_Resource	Clinical_or_Research_Facility	Glasswashing and Sterilization Shared Resource	The Glasswashing and Sterilization Shared Resource perform the preparation of clean sterile regular and special needs glassware for Cancer Center laboratories.
C39415	H_Lee_Moffitt_Cancer_Center_and_Research_Institute_at_the_University_of_South_Florida	Clinical_Cancer_Center	H Lee Moffitt Cancer Center and Research Institute at the University of'south Florida	The H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida has NCI-designated status of Clinical Cancer Center.
C39416	Health_Care_Delivery_Study	Population_Study	Health Care Delivery Study	The Health Care Delivery Study is one that focuses on economic and social effects of health care practice and delivery.
C39417	Health_Resources_and_Services_Administration	Other_Agency_or_Organization	Health Resources and Services Administration|HRSA	The Health Resources and Services Administration (HRSA) is an Access Agency of the U.S. Department of Health and Human Services, charged with improving and expanding access to quality health care for low income, uninsured, isolated, vulnerable and special needs populations and meeting their unique health care needs. Provides funds for scientific projects and public health programs.
C39418	Herbert_Irving_Comprehensive_Cancer_Center	Comprehensive_Cancer_Center	Herbert Irving Comprehensive Cancer Center	The Herbert Irving Comprehensive Cancer Center at the College of Physicians and Surgeons at the Columbia University is an NCI-designated Comprehensive Cancer Center. It is comprised of four Clinical Research Programs: Breast cancer, Urologic Malignancies, Neuro-Oncology, Experimental Therapeutics; three programs in the field of cancer causation, prevention and control: Cancerogenesis, Molecular/Cancer Epidemiology, and Cancer Causation, Prevention and Control; and four basic research programs: Molecular Oncology and Virology, Developmental Biology and Genetics, Radiation, Physics and Biology, and Immunology programs.
C39419	Histology_and_Immunohistochemistry_Shared_Resource	Clinical_or_Research_Facility	Histology and Immunohistochemistry Shared Resource	The Histology and Immunohistochemistry Shared Resource provides Cancer Center investigators with histological and immunohistochemical technical services and expert histopathological and embryological advice, including frozen sections, slides preparation and assessment, specialized histochemical staining, antigen detection, individualized immunohistochemical assays, specialized assays: TUNEL, BrdU, beta galactosidase, etc. interpretation assistance and confirmation of diagnosis.'
C39420	Holden_Comprehensive_Cancer_Center_at_the_University_of_Iowa	Comprehensive_Cancer_Center	Holden Comprehensive Cancer Center at the University of Iowa	The Holden Cancer Center at the University of Iowa coordinates all cancer-related research, education, and patient care throughout the University by faculty from 38 departments in six colleges, as well as UI Hospitals and Clinics. The Holden Cancer Center at the University of Iowa was recognized by the National Cancer Institute as an NCI-designated Cancer Center in 2000 and received 'comprehensive' status shortly thereafter.
C39421	Human_Pharmacology_Study	Clinical_Study	Human Pharmacology Study	The Human Pharmacology Study is a clinical study that involves one or more of following activities: assesses tolerance to the agent, defines/describes pharmacokinetics and pharmacodynamics, explores drug metabolism, drugs interactions, and evaluates agent activity. The term usually refers to early clinical stages of drug development.
C39422	Huntsman_Cancer_Institute_at_the_University_of_Utah	Clinical_Cancer_Center	Huntsman Cancer Institute at the University of Utah|HCI	The Huntsman Cancer Institute at the University of Utah is an NCI-designated Clinical Cancer Center.
C39423	Illustration_Graphic_Art_Publication_and_Audiovisual_Service_Shared_Resource	Clinical_or_Research_Facility	Illustration Graphic Art Publication and Audiovisual Service Shared Resource	The Art Services Shared Resource supports Cancer Center members by providing advice, customized design, and reproduction services to meet the needs of individual scientists, departments and educational programs for art, computer-imaging, graphics and photography services, including needs for scientific publications and presentations, printing, and audiovisual media.
C39424	Immune_Monitoring_Shared_Resource	Clinical_or_Research_Facility	Immune Monitoring Shared Resource	The Immune Monitoring Shared Resource provides support to Cancer Center investigators in Immune status evaluation techniques including autoMACS magnetic bead cell separation, cell proliferation assays, cytokine assays, leukocyte subset C217
C39425	Immunoelectron_Microscopy_Shared_Facility	Clinical_or_Research_Facility	Immunoelectron Microscopy Shared Facility	The Immunoelectron Microscopy Shared Resource provides support to Cancer Center investigators in ultrastructural analysis by conventional electron microscopy in conjunction with immunolocalization techniques, including ultra-cryomicrotomy, and internal antigens immuno-labeling.
C39426	In_Situ_Hybridization_Shared_Resource	Clinical_or_Research_Facility	In Situ Hybridization Shared Resource	The In Situ Hybridization Shared Resource provides Cancer Center investigators with histological review and interpretation of immunohistochemical and in situ hybridization studies of human and experimental animal solid tumor specimens.
C39427	Indiana_University_Cancer_Center	Clinical_Cancer_Center	Indiana University Cancer Center	The Indiana University Cancer Center is an NCI-designated Clinical Cancer Center.
C39428	Industrial_Trial_Standard_Cancer_Center_Information_Summary	Grants_Preparing_Applications	Industrial Trial Standard Cancer Center Information Summary	The Industrial Trial, Standard Cancer Center Information Summary for Cancer Center Support Grant Application, is a clinical study which design and implementation is controlled by the pharmaceutical company.
C39429	Institute_for_Cancer_Prevention	Cancer_Center	Institute for Cancer Prevention|American Health Foundation	The Institute for Cancer Prevention is an NCI-designated Cancer Center. Since 2001, the Institute has been rapidly expanding its translational research and now is a home to a Clinical Nutrition Research Unit and is the coordinating institution for a 30-center national clinical trial - Women's Intervention Nutrition Study.
C39430	Institutional_Commitment_Section_of_Cancer_Center_Support_Grant_Application	Grants_Preparing_Applications	Institutional Commitment Section of Cancer Center Support Grant Application	The Institutional Commitment section of the Cancer Center Support Grant Application includes a schematic description of the Cancer Center's position within the institution(s) in relation to other organizational components (e.g., schools, departments, institutes, or the equivalent).
C39431	International_Agency_for_Research_on_Cancer	Other_Agency_or_Organization	International Agency for Research on Cancer|IARC	International Agency for Research on Cancer is part of the World Health Organization that coordinates and conducts both epidemiological and laboratory research into the causes of cancer. The Agency's work has four main objectives: to monitor global cancer occurrence in terms of cancer incidence, mortality, survival, and registration worldwide; cancer causes identification; elucidation of mechanisms of carcinogenesis, and development of scientific strategies for cancer control.
C39432	International_Cancer_Research_Portfolio_Database	Data_Sources	International Cancer Research Portfolio Database|ICRP	The International Cancer Research Portfolio (ICRP) is a searchable database of information on cancer research awards of the cancer funding organizations that comprise the Common Scientific Outline Partners. The ICRP provides the public at-large with opportunity to view and browse information about research supported by cancer funding organizations in the US and the UK.
C39433	International_Society_of_Preventive_Oncology	Other_Agency_or_Organization	International Society of Preventive Oncology|ISPO	The International Society of Preventive Oncology (ISPO) is the forum of an international membership committed to the study of interactive etiologic factors in cancer development and their impact on prevention, detection, and management of neoplastic diseases. Publishes CDP (Cancer Detection and Prevention) Journal.
C39434	International_Union_Against_Cancer	Other_Agency_or_Organization	International Union Against Cancer|UICC	The International Union Against Cancer (UICC) is the only global cancer organisation with members and activities covering all aspects of cancer control. Founded in 1933, UICC is an independent, international, non-governmental association of 291 member cancer fighting organizations in 87 countries. Located in Geneva, Switzerland.
C39435	Intervention_Community_Trial	Community_Trial	Intervention Community Trial	The Intervention Community Trial is a controlled study that involves modification of causal or conjectural causal factors in a population to test a cause-effect relationship.
C39436	Ireland_Cancer_Center	Comprehensive_Cancer_Center	Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University|ICC	Ireland Cancer Center at University Hospitals of Cleveland and Case Western Reserve University is an NCI-designated Comprehensive Cancer Center. Major research areas are: signal transaction processes in cancer, hormone responsive malignancies and apoptosis, cancer virology, cancer genetics, radiation biology, hematopoietic and immune cell biology, developmental therapeutics, behavioral cancer prevention and control, genetic epidemiology, imaging, aging and cancer. The Center has an extensive Clinical Research Program in the fields of breast, genito-urinary, digestive system, head and neck cancers, HIV-related malignancies, leukemia, lymphoma, melanoma, multiple myeloma, as well as in gynecology, neuro oncology, pediatric oncology, thoracic oncology, and transplantation.
C39437	Irradiation_Shared_Resource	Clinical_or_Research_Facility	Irradiation Shared Resource	The Irradiation Shared Resource provides Cancer Center investigators with support in the following areas: cell, tumor, specimen, animal irradiation for studies of radiobiologic mechanisms or to suppress immune responses in experimental animals, as well as to sterilize various cell, vaccine and drug preparations; radiotherapy models development and treatment planning, laser and photodynamic therapy, in vivo imaging, in vivo fluorescent imaging, atomic absorption spectroscopy, DNA damage and other radiation assays, safety training and dosimetry measurements.
C39438	Jonsson_Comprehensive_Cancer_Center_of_University_of_California_Los_Angeles	Comprehensive_Cancer_Center	Jonsson Comprehensive Cancer Center of University of California Los Angeles|JCCC|The UCLA's Jonsson Comprehensive Cancer Center	The UCLA's Jonsson Cancer Center was designated comprehensive status by NCI in 1976. With a membership of more than 230 physicians and scientists, the Center carries out studies through four basic research programs (Signal Transduction, Cancer Cell Biology, Tumor Immunology, Virology), four clinical/translational research programs (Women's Cancers, Genitourinary Oncology, Hematopoietic Malignancies, Cancer Translational Therapeutics), and two cancer prevention and control programs (Healthy and at Risk Populations, Patients and Survivors).
C39439	Kaplan_Cancer_Center	Comprehensive_Cancer_Center	Kaplan Cancer Center|Kaplan Cancer Center at NYU|The NYU Cancer Institute	The Rita J. & Stanley H. Kaplan Cancer Center at the New York University Medical Center became an NCI-designated comprehensive cancer center in 1991. It is comprised of six basic research and population research programs (Stem Cell Biology, Cancer Epidemiology and Prevention, cancer Immunology, Cancer Neurobiology, Environmental - and Molecular Carcinogenesis, Growth Control); seven disease-specific clinical research programs, and eleven shared resources.
C39440	Kimmel_Cancer_Center_at_the_Thomas_Jefferson_University	Clinical_Cancer_Center	Kimmel Cancer Center at the Thomas Jefferson University|KCC at the Thomas Jefferson University	The Kimmel Cancer Center at the Thomas Jefferson University - is an NCI-designated clinical cancer center. Basic scientists are organized into four programs focused on: cell biology and signaling, genetics and molecular biology, immunology, and structural biology and Bioinformatics. Medical science programs include the Developmental Therapeutics Program, the Hematologic Malignancies and Stem Cell Transplantation Program, and the Gastrointestinal Cancer Program. The KCC offers its members access to 16 core facilities.
C39441	Laboratory_Animal_Genetic_Monitoring_Resource	Clinical_or_Research_Facility	Laboratory Animal Genetic Monitoring Resource	The Genetic Monitoring Facility functions to protect the genetic integrity of the inbred strains and transgenic lines of rodents utilized in the various research programs at Fox Chase. Rodents used in today's biomedical research must not only be free of disease that may influence experimental results, but also be well-defined in terms of their genetic makeup. This is especially true with the increasing use of transgenic mice in most areas of biomedical research.
C39442	Laboratory_Animal_Health_and_Quality_Control_Shared_Resource	Clinical_or_Research_Facility	Laboratory Animal Health and Quality Control Shared Resource|General Technical Animal Service	The Laboratory Animal Health and Quality Control Shared Resource provides the primary conventional services including experimental animals health monitoring, maintenance of an specific pathogen free colonies, diagnostic services, disease elimination program, strict quarantine procedures, teaching and training for investigators and their technicians, consultation with investigators, and technical services.
C39443	Laboratory_Animal_Husbandry_Shared_Resource	Clinical_or_Research_Facility	Laboratory Animal Husbandry Shared Resource	The Laboratory Animal Husbandry Shared Resource provides basic husbandry service as well as technical support services to the Cancer Center research community. The Laboratory maintains centralized foundation breeding colonies, production colonies of selected strains, and special breeding and embryo transfer rederivation of animals for use by Cancer Center investigators.
C39444	Laboratory_Animal_Shared_Resource	Clinical_or_Research_Facility	Laboratory Animal Shared Resource	The Laboratory Animal Shared Resource is responsible for the supply, use, husbandry, and experimental model selection and development of laboratory animals utilized by the research programs at Cancer Center. The resource provides direction on appropriate techniques, strains or animal models to use in research protocols, maintains a pathogen-free environment, health surveillance, quarantine, full-panel testing and genetic monitoring for experimental animals.
C39445	Local_Protocol_Standard_Cancer_Center_Information_Summary	Grants_Preparing_Applications	Local Protocol Standard Cancer Center Information Summary	The Local Protocol, Standard Cancer Center Information Summary for Cancer Center Support Grant Application, is a study conducted by the reporting Cancer Center primarily in its catchment area (including institutional trials, either exclusive to the Center or in collaboration with other Centers, industry-sponsored trials, and other externally peer-reviewed trials).
C39446	Machine_Shop_Shared_Resource	Clinical_or_Research_Facility	Machine'shop Shared Resource	The Machine Shop Shared is available at Cancer Center to provide machining services, sheet metal work, wood work, welding, and consulting in support of the research activities.
C39447	Mass_Spectrometry_Shared_Resource	Clinical_or_Research_Facility	Mass'spectrometry Shared Resource	Mass Spectrometry Shared Resource provides support to cancer researchers in structural studies of proteins, peptides, nucleic acids, drug-DNA complexes, and complex carbohydrates. It provides molecular weight information on biomolecules, confirms the structure of expressed proteins and detects post-translational modifications, confirms the identity of synthetic peptides, detect and characterizes synthetic intermediates, identifies proteins in gel tryptic digests, screens proteins and peptides for purity.
C39448	Massey_Cancer_Center_at_the_Virginia_Commonwealth_University	Clinical_Cancer_Center	Massey Cancer Center at the Virginia Commonwealth University	Master of Health Services Administration is a master's degree in health administration and health care management.
C39449	Master_of_Business_Administration	Master_s_Degree	Master of Business Administration|M.B.A.|MBA	The Massey Cancer Center at the Virginia Commonwealth University Health System is an NCI-designated Clinical Cancer Center. Research at the Center is currently organized into five thematic programs: Cancer Cell Biology, Developmental Therapeutics, Immune Mechanisms, Radiation Biology and Oncology, and Cancer Control, and is supported by 11 shared resources.
C39450	Master_of_Health_Services_Administration	Master_s_Degree	Master of Health Services Administration|M.H.A.|M.H.S.A.|MHA|MHSA	Master of Business Administration is a master's degree in business.
C39451	Master_of_Public_Health	Master_s_Degree	Master of Public Health|M.P.H.|MPH	The Master's of Public Health is an academic degree awarded to graduates who have completed a program of studies in public health that usually address human population health, community program administration, research, and health policy development.
C39452	Master_of_Science	Master_s_Degree	Master of Science|M.S.|MS	The Master of Science Degree is an academic degree in science. The degree's classification includes such degrees in any scientific field.
C39453	Master_s_Degree	Academic_Degree	Master's Degree	The Master's Degree is an award that requires the successful completion of a program of study of at least the full-time equivalent of 1 but not more than two academic years of work beyond the bachelor's degree.
C39454	Mayo_Clinic_Cancer_Center	Comprehensive_Cancer_Center	Mayo Clinic Cancer Center	Mayo Clinic Cancer Center is an NCI-designated Comprehensive Cancer Center. The NCI first awarded its designation to Mayo Clinic Cancer Center in 1973.
C39455	McArdle_Laboratory_for_Cancer_Research	Cancer_Center	McArdle Laboratory for Cancer Research|The Department of Oncology of the University of Wisconsin-Madison	The McArdle Laboratory for Cancer Research, the Department of Oncology of the University of Wisconsin-Madison, is an NCI-designated Cancer Center. The McArdle Laboratory has 21 independent research laboratories organized into following programs: Tumor Virology, Signal Transduction, Cell Cycle, Cancer Genetics, Chemical Carcinogenesis. The Laboratory has 13 shared facilities.
C39456	Media_Preparation_Shared_Resource	Clinical_or_Research_Facility	Media Preparation Shared Resource	The Media Preparation Shared Resource provides Cancer Center investigators with a quality-controlled supply of culture media, reagents, and preparations.
C39457	Memorial_Sloan-Kettering_Cancer_Center	Comprehensive_Cancer_Center	Memorial Sloan-Kettering Cancer Center|MSKCC	The Memorial Sloan-Kettering Cancer Center, an NCI-designated Comprehensive Cancer Center, is composed of Memorial Hospital for Cancer and Allied Diseases and the Sloan-Kettering Institute, its basic-science research arm. The Center includes the Cancer Biology and Genetics Program, the Cell Biology Program, Computational Biology Program, Developmental Biology Program, the Immunology Program, the Molecular Biology Program, the Molecular Pharmacology and Chemistry Program, the Structural Biology Program, and more than 40 clinical research programs.
C39458	Microarray_Shared_Resource	Clinical_or_Research_Facility	Microarray Shared Resource	The Microarray Shared Resource supports Cancer Center research activity performing gene expression profiling in which the activity of many thousands of genes is measured simultaneously. The Resource provides biochemical, hybridization, and scanning services, genome-wide SNP analysis and resequencing analysis, consultation in experimental design and data mining.
C39459	Molecular_Biology_Shared_Resource	Clinical_or_Research_Facility	Molecular Biology Shared Resource	Molecular Biology Shared Resource provides molecular biology services to the Cancer Center investigators including automated DNA sequencing, DNA and peptide synthesis, protein sequencing, amino acid analysis, BIAcore protein ligand assays, and mass spectrometry.
C39460	Molecular_Diagnostics_Laboratory_Shared_Resource	Clinical_or_Research_Facility	Molecular Diagnostics Laboratory Shared Resource	The Molecular Diagnostics Laboratory Shared Resource provides support to Cancer Center investigators with specimen processing and tracking, DNA sequencing, microsatellite and SNP analyses, quantitative PCR, protein analysis as well as other services, to analyze genes and genes products that are, or may be, involved in the etiology of cancer.
C39461	Molecular_Imaging_Shared_Resource	Clinical_or_Research_Facility	Molecular Imaging Shared Resource	The Molecular Imaging Shared Resource develops imaging reagents and methods that can be widely applied, develops imaging instruments, translates imaging methods to human studies, identifies biological pathways and organs for disease-specific change targeting.'
C39462	Monoclonal_Antibody_Production_Shared_Resource	Clinical_or_Research_Facility	Monoclonal Antibody Production Shared Resource|Hybridoma Core Shared Resource	The Monoclonal Antibody Production Shared Resource is responsible for monoclonal antibody generation and production, provides other antibody-related products and services to support basic research and clinical projects at Cancer Center, and conducts research on the development of related novel immunological techniques.
C39463	Mouse_Pathology_Shared_Resource	Clinical_or_Research_Facility	Mouse Pathology Shared Resource	The Mouse Pathology Shared Resource provides histologic and hematopoietic research support services to Cancer Center investigators and others studying the pathogenesis and treatment of organ and hematologic malignancies in mouse models of human cancer.
C39464	National_Alliance_of_Breast_Cancer_Organizations	Other_Agency_or_Organization	National Alliance of Breast Cancer Organizations|NABCO	The National Alliance of Breast Cancer Organizations is a New York-based non-profit education and information resource on breast cancer in the US.
C39465	National_Brain_Tumor_Foundation	Other_Agency_or_Organization	National Brain Tumor Foundation|NBTF	The National Brain Tumor Foundation (NBTF) is a national non-profit health organization dedicated to providing information and support for brain tumor patients, family members, and healthcare professionals, and supporting research efforts to develop new modalities of brain tumors treatment.
C39466	National_Cancer_Institute_Cancer_Centers_Program	Extramural_Funding_Mechanisms	National Cancer Institute Cancer Centers Program	The NCI Cancer Centers Program comprises more than 50 NCI-designated cancer centers engaged in multidisciplinary research to reduce cancer incidence, morbidity and mortality. Through Cancer Center Support grants, this program supports three types of centers: Comprehensive Cancer Centers, Clinical Cancer Centers, and Cancer Centers. It was the National Cancer Act of 1971 that strengthened the program by authorizing the establishment of 15 new cancer centers and the continued support for existing ones.
C39467	National_Cancer_Institute_of_Canada_Clinical_Trials_Group	Clinical_Trials_Cooperative_Group	National Cancer Institute of Canada Clinical Trials Group|NCIC CTG	A cooperative oncology group which carries out clinical trials in cancer therapy and supportive care across Canada and internationally. It is supported by the National Cancer Institute of Canada with funds raised by the Canadian Cancer Society.
C39468	National_Cervical_Cancer_Coalition	Other_Agency_or_Organization	National Cervical Cancer Coalition|NCCC	The National Cervical Cancer Coalition (NCCC) is a non-profit organization focused on cervical cancer issues such as cervical cancer screening programs, new technology, research and treatment. The NCCC provides outreach support to cervical cancer patients and family members.
C39469	National_Childhood_Cancer_Foundation	Other_Agency_or_Organization	National Childhood Cancer Foundation|NCCF	The National Childhood Cancer Foundation is a non-profit organization that serves as the fund-raising foundation, grantee organization, and the fiscal agent for the Children Oncology Group. The Foundation conducts its fundraising and advocacy efforts on behalf of 90% of the children with cancer in North America, receiving federal and non-federal grants and awards to distribute to the member-institutions. Advocacy and public awareness are also parts of the mission of the Foundation.
C39470	National_Coalition_for_Cancer_Research	Professional_Organization_or_Group	National Coalition for Cancer Research|NCCR	A coalition of 26 national research and lay advocacy organizations, and professional groups working to secure adequate federal funding for research to improve cancer prevention, detection, treatment, and survivorship.
C39471	National_Comprehensive_Cancer_Network	Professional_Organization_or_Group	National Comprehensive Cancer Network|NCCN	An alliance of 19 leading US cancer centers, an authoritative source of information to help patients and health professionals make informed decisions about cancer care. Through the collective expertise of its member institutions, the NCCN develops, updates, and disseminates a complete library of clinical practice guidelines. These guidelines are the standard for clinical policy in oncology.
C39472	National_Protocol_Standard_Cancer_Center_Information_Summary	Grants_Preparing_Applications	National Protocol Standard Cancer Center Information Summary	The National Protocol, Standard Cancer Center Information Summary for Cancer Center Support Grant Application, is a multi-institutional trial in which the Cancer Center provides leadership or is a participant. The concept includes trials conducted by National Cooperative Groups.
C39473	Naturopathic_Doctor	Doctor_s_Degree	Naturopathic Doctor|N.D.|ND	The Naturopathic Doctor (N.D.) degree is a degree awarded for graduates who have completed a medical doctoral program in accredited school. N.D. has a qualification of primary care physicians with a specialized focus in preventative medicine, natural therapeutics, and emphasis on holistic and nontoxic approaches to therapy and optimizing wellness.
C39474	NCI-Funded_Research_Portfolio_Database	Data_Sources	NCI-Funded Research Portfolio Database	The NCI-Funded Research Portfolio Database is a searchable database that contains information about research grant and contract awards made by the NCI for the current and past five fiscal years.
C39475	Neuroblastoma_Children_s_Cancer_Society	Other_Agency_or_Organization	Neuroblastoma Children's Cancer Society|NCCS	The Neuroblastoma Children's Cancer Society is an advocate group dedicated to serving as a support center for children who suffer from neuroblastoma and their families and to fundraising and funding research efforts to develop new modalities of childhood neuroblastoma treatment.
C39476	Non-programmatically_Aligned_Cancer_Center_Research_Member_Section_of_Cancer_Center_Support_Grant_Application	Business_Rules	Non-programmatically Aligned Cancer Center Research Member Section of Cancer Center Support Grant Application	Non-programmatically Aligned Cancer Center Research Members are Cancer Center faculty and staff not affiliated with any of its research programs. A list of non-aligned cancer center members with their departmental affiliations, areas of expertise and research interests and description of the strategies used to take advantage of their scientific expertise in furthering the research objectives of the center, is an essential part of the Cancer Center Support Grant Application.
C39477	Norris_Cotton_Cancer_Center	Cancer_Center	Norris Cotton Cancer Center|Norris Cotton Cancer Center at the Dartmouth-Htchcock Medical Center	The Cotton Cancer Center is an NCI-designated Cancer Center at the Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire.
C39478	Nuclear_Magnetic_Resonance_Shared_Resource	Clinical_or_Research_Facility	Nuclear Magnetic Resonance Shared Resource	Nuclear Magnetic Resonance (NMR) Shared Resource serves cancer research projects in the field of structural biology as well as in synthesis and analysis of complex natural products and synthetic molecules, including conformational analysis and relationship of structure and biological activity.
C39479	Nude_Mouse_Shared_Resource	Clinical_or_Research_Facility	Nude Mouse Shared Resource	The Nude Mouse Shared Resource provides immunodeficient mice to Cancer Center investigators, appropriate housing and maintenance for these animals, as well as technical expertise and barrier working laboratories for in vivo experiments.
C39480	Nutrition_Shared_Resource	Clinical_or_Research_Facility	Nutrition Shared Resource	The Nutrition Shared Resource provides Cancer Center investigators with support in dietary and nutritional assessment and monitoring, including quantitative measurements of biochemical indicators of diet and other biomarkers in blood and other biological samples, for research that address nutritional or dietary factors in cancer prevention and treatment. The resource provides counseling service for promoting dietary change, surveys, and meta-analyses of available data.
C39481	Office_of_Assistant_Secretary_of_Health	Other_Agency_or_Organization	Office of Assistant'secretary of Health|AOSH	The Office of Assistant Secretary of Health (OASH) is a component of the Department of Health and Human Services. OASH administers and exercises oversight responsibility for the Public Health Service (PHS) and its component health agencies. The PHS is comprised of all agency divisions of HHS and the Commissioned Corps, uniformed health professionals who serve at HHS and other federal agencies. OASH provides funds for research and public health programs.
C39482	Oligonucleotide_Synthesis_Shared_Resource	Clinical_or_Research_Facility	Oligonucleotide Synthesis Shared Resource	Oligonucleotide Synthesis Shared Resource provides Cancer Center members with custom chemical synthesis of oligonucleotides of defined sequence.
C39483	Optical_Microscopy_Shared_Resource	Clinical_or_Research_Facility	Optical Microscopy Shared Resource	The Optical Microscopy Shared resource provides support for Cancer Center investigators in identification relevant methods for imaging study, and assists researchers with experimental design, image acquisition, training, technical support, and data interpretation.
C39484	Organic_and_Synthetic_Chemistry_Shared_Resource	Clinical_or_Research_Facility	Organic and'synthetic Chemistry Shared Resource	Organic and Synthetic Chemistry Shared Resource provides researchers in Cancer Center with custom synthesis of chemicals pertaining to cancer biology in terms of causation, prevention, and intervention, that are not commercially available or are prohibitively expensive, and expertise in biocatalysis, organometallics, chiral synthesis, biotransformations, enzyme inhibitors. Resource also provides consultations regarding problems in chemical synthesis and modification, assistance in the spectroscopic characterization of unknown compounds, access to combinatorial synthesis, and support in drug development efforts.
C39485	Other_Clinical_Research_Support_Shared_Resource	Clinical_or_Research_Facility	Other Clinical Research Support Shared Resource	Other Clinical Research Support Shared Resource provides types of support for Cancer Center investigators that are not provided by shared resources listed above.
C39486	Other_Epidemiology_and_Cancer_Control_Shared_Resource	Clinical_or_Research_Facility	Other Epidemiology and Cancer Control Shared Resource	Other Epidemiology and Cancer Control Shared Resource provides services not provided by resources listed above.
C39487	Other_Informatics_Shared_Resource	Clinical_or_Research_Facility	Other Informatics Shared Resource	Other Informatics Shared Resource provides Cancer Center investigators with types of informatics support that are not listed as provided by other informatics shared resources.
C39488	Other_Laboratory_Science_Support_Shared_Resource	Clinical_or_Research_Facility	Other Laboratory Science Support Shared Resource	Other Laboratory Science Support Shared Resource provides types of laboratory support for Cancer Center investigators that are not provided by shared resources listed above.
C39489	P20_Planning_Cancer_Center	Cancer_Center	P20 Planning Cancer Center	A P20 Planning Cancer Center is an institution awarded with an NCI-provided P20 Cancer Center Planning Grant.
C39490	Patient_Compliance	Personal_Behavior	Patient Compliance|Compliance	Patient Compliance is the extent to which the patient conforms to medical advice regarding prescribed regimen, lifestyle, dietary changes, follow-up schedule and other recommendations.
C39491	Peer-reviewed_Scientific_Project	Research	Peer-reviewed Scientific Project	The peer-reviewed scientific project is one which proposal was reviewed by experts in the field who are not part of the project staff (in some cases, are not affiliated with the submitting institution), and do not have any conflicts of interest that could bias their opinions. The number of reviewers, the reviewing procedures and criteria, and the use made of the reviewers' opinions may vary, and therefore each reviewing organization/committee has to publicly disclose its policies.
C39492	Pharmaceutical_Research_Shared_Resource	Clinical_or_Research_Facility	Pharmaceutical Research Shared Resource	The Pharmaceutical Research Shared Resource provides support to Cancer Center investigators involved in clinical research related to anticancer therapy with maintaining drug accountability records and investigational drug inventories according to FDA guidelines. The resource provides design consultation, professional staff education, implementation and report completion services for clinical studies, adverse drug reaction reports evaluation to ensure compliance with regulatory agencies.
C39493	Pharmacoeconomic_Study	Research_Activity	Pharmacoeconomic Study	The Pharmacoeconomic Study is one that assesses the value associated with a given drug in therapeutic and economic terms. This type of study is multidisciplinary in nature and takes into consideration the social and economic costs (resource utilization costs including direct, indirect, and intangible costs) of drug therapy in addition to its direct therapeutic benefits. Analyses relate the difference in therapeutic benefits to the difference in costs between treatment alternatives.
C39494	Pharmacology_Shared_Resource	Clinical_or_Research_Facility	Pharmacology Shared Resource	The Pharmacology Shared Resource provides Cancer Center investigators conducting preclinical and clinical studies with analytical and technical pharmacology support in the areas of sample handling and tracking, pharmacokinetic modeling, drug-drug interaction, pharmacodynamics, drug assays, in vitro toxicity assays and molecular analysis of tumor tissue; human safety issues, adverse reactions risk evaluation and management, chemotherapy monitoring; assistance in study design, optimal sampling techniques and data interpretation.
C39495	Pre-Clinical_Magnetic_Resonance_Imaging_Shared_Resource	Clinical_or_Research_Facility	Pre-Clinical Magnetic Resonance Imaging Shared Resource	The Pre-Clinical Magnetic Resonance Imaging Shared Resource provides heteronuclear magnetic resonance imaging (MRI) and spectroscopy expertise and facilities to Cancer Center investigators in designing, implementing and analyzing their image-based research on therapeutic assessments, diagnosis and monitoring of cancer progression, tumor characterization, molecular and cellular assessments, developing multimodality contrast enhancing agents, quality assurance testing of medical devices, development of therapies, and in studies of solid state and semi-solid state media samples.
C39496	Preventive_Clinical_Trial	Clinical_Study	Preventive Clinical Trial	The Preventive Clinical Trial is a controlled clinical study that involves administering of exposure to the agent to healthy subjects to test efficacy of this agent in prevention of specific medical condition.
C39497	Preventive_Community_Trial	Community_Trial	Preventive Community Trial	The Preventive Community Trial is a controlled study that involves administration of preventive program or/and preventive treatments in community.
C39498	Proteomics_Shared_Resource	Clinical_or_Research_Facility	Proteomics Shared Resource	Proteomics Shared Resource provides analysis and characterization of natural and recombinant proteins and candidate drugs and protein expression and profiling analysis using a combination of technologies: mass mapping and identification of unknown proteins from databases, HPLC-MS identification of components of macromolecular complexes, identification of sites of posttranslational modifications, sequencing, and screening techniques.
C39499	Protocol_Development_Shared_Resource	Clinical_or_Research_Facility	Protocol Development Shared Resource	The Protocol Development Shared Resource provides Cancer Center investigators with support in clinical and experimental research protocol development, including protocol content and form, sample size and patient safety related issues, and cost estimates to aid in budget development.
C39500	Public_Affairs_Network_of_Cancer_Centers	Professional_Organization_or_Group	Public Affairs Network of Cancer Centers|PAN
C39501	Public_Health_and_Epidemiology_Informatics_Shared_Resource	Clinical_or_Research_Facility	Public Health and Epidemiology Informatics Shared Resource	The Public Health and Epidemiology Informatics shared resource provides Cancer Center investigators with support in development informatics tools for public health programs, epidemiologic studies, cancer surveillance, interventional trials, and data collection, verification, analysis, and dissemination.
C39502	Purdue_Cancer_Center	Cancer_Center	Purdue Cancer Center	The Purdue Cancer Center is an NCI-designated Cancer Center
C39503	Radiolabeling_Shared_Resource	Clinical_or_Research_Facility	Radiolabeling Shared Resource	Radiolabeling Shared Resource provides Cancer Center investigators with support in preparation of radiolabeled reagents (proteins, peptides, hormones, oligonucleotides, antibodies, etc.) for in vitro and in vivo human and animal models studies, and is responsible for analysis of radiolabeled reagents for purity, specificity, structural integrity, degree of isotope binding, reactivity, and quality control. The resource assists in the preparation of Investigational New Drug applications to FDA on promising radiolabeled compounds for application in cancer diagnosis and treatment.
C39504	Rebecca_and_John_Moores_University_of_California_at_San_Diego_Cancer_Center	Comprehensive_Cancer_Center	Rebecca and John Moores UCSD Cancer Center|Rebecca and John Moores University of California at San Diego Cancer Center|The UCSD Cancer Center	The Rebecca and John Moores University of California at San Diego Comprehensive Cancer Center was founded in 1979. Research activities are grouped in seven programs: Cancer Biology, Cancer Genetics, Cancer Pharmacology, Cancer Prevention and Control, Cancer Symptom Control, Translational Oncology, Viral Malignancy. There are more than 260 faculty members of the Center, and 12 shared resources providing investigators with access to expensive equipment and specialized expertise. At any given time, the Cancer Center offers nearly 200 clinical trials.
C39505	Reportable_Cancer_Standard_Cancer_Center_Information_Summary	Grants_Preparing_Applications	Reportable Cancer Standard Cancer Center Information Summary	The Reportable Cancer, Standard Cancer Center Information Summary for Cancer Center Support Grant Application, is a case of malignant and carcinoma in-situ neoplasm in patient that was treated at Cancer Center during 12-month reporting period. Only primary malignant tumors have to be reported. ICD-O classification is to be used.
C39506	Reportable_Patient_Standard_Cancer_Center_Information_Summary	Cancer_Center|Grants_Preparing_Applications	Reportable Patient Standard Cancer Center Information Summary	The Reportable Patient, Standard Cancer Center Information Summary for Cancer Center Support Grant Application, is a Cancer Center patient with malignant neoplasm that was seen face-to-face and registered at Cancer Center in inpatient or outpatient setting during 12-month reportable period. The concept does not refer to consults, diagnoses at autopsy, former patients admitted for rehabilitation, and follow-up patients after treatment completion.
C39507	Reporting_Period_for_Cancer_Center_Support_Grant	Grants_Preparing_Applications	Reporting Period for Cancer Center Support Grant	The Reporting Period for Cancer Center Support Grant, is the 12-month period for which data are being provided for Standard Cancer Center Information Summary.
C39508	Robert_H_Lurie_Comprehensive_Cancer_Center_of_Northwestern_University	Comprehensive_Cancer_Center	Robert H Lurie Comprehensive Cancer Center of Northwestern University	The Robert H. Lurie Cancer Center of Northwestern University received NCI-designated status of comprehensive in
C39509	Roswell_Park_Cancer_Institute	Comprehensive_Cancer_Center	Roswell Park Cancer Institute	Roswell Park Cancer Institute, an NCI-designated Comprehensive Cancer Center, is comprised of sixteen basic research, population research, and translational/clinical programs, and sixteen shared resources.
C39510	Saint_Jude_Children_s_Research_Hospital	Clinical_Cancer_Center	Saint Jude Children's Research Hospital	The Saint Jude Children's Research Hospital is an NCI-designated Clinical Cancer Center. Research is focused specifically on childhood cancers, acquired and inherited immunodeficiencies and genetic disorders.
C39511	San_Antonio_Cancer_Institute	Comprehensive_Cancer_Center	San Antonio Cancer Institute|SACI	The San Antonio Cancer Institute is an NCI-designated Comprehensive Cancer Center. It represents the combined cancer research programs of the Cancer Therapy and Research Center and the University of Texas Health Science Center at San Antonio. There are six major research programs within the Institute: Cancer Metastasis, Cancer Prevention and Health Promotion, DNA Repair and Tumor Suppressor Genes, Experimental Therapeutics, Geriatric Oncology, and Signal Transduction and Macromolecular Interactions. The Institute provides its members with 14 shared recourses.
C39512	Secretarial_and_Word_Processing_Shared_Resource	Clinical_or_Research_Facility	Secretarial and Word Processing Shared Resource	Secretarial and Word Processing Shared Resource provides secretarial and technical support to Cancer Center members including preparation of typed material, distribution of postal and electronic mail, scheduling conference/rooms/seminars, FedEx supplies coordination.
C39513	Shared_Resource_Cancer_Center	Clinical_or_Research_Facility	Shared Resource Cancer Center|Cancer Center Core Resource|Cancer Center Shared Facility	The Shared Resources and Facilities of Cancer Centers are defined as centralized facilities and services that have been structured to fulfill the needs of the multi-disciplinary research programs. The facilities and resources have been designed to enhance on-going research by supplying information, reagents, equipment, and technical expertise that are not readily available to the individual investigator, and to enhance research productivity, foster scientific collaborations, and increase organizational and administrative cohesiveness.
C39514	Sidney_Kimmel_Cancer_Center_at_Johns_Hopkins_University	Comprehensive_Cancer_Center	Sidney Kimmel Cancer Center at Johns Hopkins University	The Sidney Kimmel Cancer Center at the Johns Hopkins University is a Comprehensive Cancer Center. Areas of research include biostatistics, cancer biology, cancer immunology, cancer prevention and control, experimental and therapeutic hematopoiesis, experimental therapeutic and solid tumors research, pediatric, radiation oncology, urologic oncology, viral oncology, and The Maryland Cigarette Restitution Fund Cancer Research Project.
C39515	Small_Animal_Imaging_Shared_Resource	Clinical_or_Research_Facility	Small Animal Imaging Shared Resource	The Small Animal Imaging Shared Resource provides Cancer Center investigators with imaging technologies for small animals, emphasizing, but not limited to those which can provide biochemical, genetic or pharmacological information in vivo, and training for both professional and technical personnel in the techniques and methodologies of small animal imaging.
C39516	Small_Molecule_Screening_Shared_Resource	Clinical_or_Research_Facility	Small Molecule Screening Shared Resource	The Small Molecule Screening Shared Resource is dedicated to provide Cancer Center members with access to high throughput screening of structurally-diverse, drug-like chemicals in appropriate biological assays. The resource provides screening and liquid handling equipment, informatics for data handling and analysis, assay design expertise, centralized storage of compound libraries and develops new methodologies for screening of small molecule agents that inhibit cancer phenotypes in cellular or animal models.
C39517	Social_Science_Shared_Resource	Clinical_or_Research_Facility	Social Science Shared Resource	The Social Science Shared Resource provides Cancer Center investigators with theoretical (applied and developmental), measurement and statistical design expertise in the studies of behavioral risks, risk reduction, screening behavior, quality of life, quality of care and health care delivery. The resource assists investigators in psychometric assessment of instruments for studies related to cancer etiology and treatment, develops sampling schemes, surveys, interview training, quality control procedures, and regulatory documents.
C39519	Standard_Cancer_Center_Information_Summary	Grants_Preparing_Applications	Standard Cancer Center Information Summary	The Standard Cancer Center Information Summary is a supplement to the Cancer Center Support Grant Application Form PHS 398. There are five types of summaries itemizing for easy reference the center's research programs, senior leaders, shared resources, base of funded research projects, patient information, clinical research protocols, and comparison of the current and requested budgets.
C39520	Study_of_Disease_Management	Research_Activity	Study of Disease Management	The Study of Disease Management is one that involves evaluations of developing treatments, modalities or preventive measures and has outcomes with direct clinical relevance. Most clinical trials fit within this category.
C39521	Study_of_Disease_Mechanisms	Research_Activity	Study of Disease Mechanisms	The Study of Disease Mechanisms is either descriptive or analytic study that requires laboratory methods and clinical observations under controlled conditions to investigate disease etiology and/or pathogenesis, e.g. metabolic and pharmacologic studies.
C39522	Substance_Abuse_and_Mental_Health_Services_Administration	Other_Agency_or_Organization	Substance Abuse and Mental Health Services Administration|SAMHSA	The Substance Abuse and Mental Health Services Administration (SAMHSA) is a Federal agency charged with improving the quality and availability of prevention, treatment, and rehabilitative services in order to reduce illness, death, disability, and cost to society resulting from substance abuse and mental illnesses. Provides funds for scientific research.
C39523	Survey_Shared_Resource	Clinical_or_Research_Facility	Survey Shared Resource	The Survey Shared Resource provides Cancer Center investigators with support in the survey methodology and conduct, questionnaires development, data quality control, database design, and data analysis
C39524	Susan_G_Komen_Breast_Cancer_Foundation	Other_Agency_or_Organization	Susan G Komen Breast Cancer Foundation	The Susan G. Komen Breast Cancer Foundation is the Dallas-based non-profit organization dedicated support of innovative breast cancer research and community-based outreach programs. The Komen Foundation fulfills its mission by funding research grants and supporting education, screening and treatment projects in communities around the world.
C39525	Targeted_Accrual_Standard_Cancer_Center_Information_Summary	Grants_Preparing_Applications	Targeted Accrual Standard Cancer Center Information Summary	The Targeted Accrual, Standard Cancer Center Information Summary for Cancer Center Support Grant Application, is the total number of patients needed for the entire clinical trial as stated in the protocol. Not a targeted range, but the number of patients the Cancer Center expects to accrue over the next 12 months of the reporting period should be indicated in the document.
C39526	Technology_Development_Study	Research_Activity	Technology Development Study	The Technology Development Study is one that includes development and mechanistic testing of new diagnostic and therapeutic methods.
C39527	The_Antitumor_Testing_Shared_Resource	Clinical_or_Research_Facility	The Antitumor Testing Shared Resource	The Antitumor Testing Shared Resource provides Cancer Center investigators with in vitro and in vivo testing and screening service aimed on identification and preclinical evaluation of potential anticancer drugs.
C39528	The_Comprehensive_Cancer_Center_Arthur_G_James_Cancer_Hospital_and_Richard_J_Solove_Research_Institute_at_Ohio_State_University	Comprehensive_Cancer_Center	The Comprehensive Cancer Center Arthur G James Cancer Hospital and Richard J Solove Research Institute at Ohio State University|OSUCCC	The Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at The Ohio State University includes several scientific programs: the Bone Marrow Transplant Program, the Human Cancer Genetics Program, the Cancer Pain and Palliative Medicine Program, and divisions: Surgical Oncology, Radiation Oncology, Pathology, Gynecologic Oncology, Urologic Surgery, Orthopaedic Oncology.
C39529	The_Jackson_Laboratory	Cancer_Center	The Jackson Laboratory|JAX|Jackson Labs	The Jackson Laboratory is an NCI-designated Cancer Center. Research programs include mouse genome informatics, comparative genomics, bone, cervical, liver, mammary, ovarian cancers, and leukemia and lymphoma. The Laboratory is the internationally recognized premier resource for genetically defined and genetically modified mice.
C39530	The_Lombardi_Cancer_Center	Comprehensive_Cancer_Center	The Lombardi Cancer Center	The Comprehensive Cancer Center at The Georgetown University. It received a NCI-designated comprehensive status in 1990.
C39531	The_University_of_California_Davis_Clinical_Cancer_Center	Clinical_Cancer_Center	The University of California Davis Clinical Cancer Center|The UC Davis Cancer Center	The University of California Davis Cancer Center is cancer research and clinical institution with more than 200 scientists in more than a dozen scientific disciplines actively engaged in cancer research. The Center offers 150 adult clinical trials and 50 pediatric clinical trials at any given time
C39532	The_University_of_California_San_Francisco_Cancer_Center	Comprehensive_Cancer_Center	The University of California San Francisco Cancer Center	The Comprehensive Cancer Center at the University of California, San Francisco.
C39533	The_University_of_Colorado_Cancer_Center	Cancer_Center	The University of Colorado Cancer Center	The University of Colorado Cancer Center is a Comprehensive Cancer Center at University of Colorado Health Science Center.
C39534	The_Vanderbilt-Ingram_Cancer_Center_at_the_Vanderbilt_University	Clinical_Cancer_Center	The Vanderbilt-Ingram Cancer Center at the Vanderbilt University|VICC	Vanderbilt-Ingram Cancer Center at the Vanderbilt University is an NCI-designated Clinical Cancer Center. It has seven research programs: Signal Transduction and Cell Proliferation program, Host-Tumor Interactions program, Gastrointestinal Cancer Program, Cancer Genetics Program, Breast Cancer Program, Cancer Prevention and Control Program, and Experimental Therapeutics Program.
C39535	The_Wistar_Institute	Cancer_Center	The Wistar Institute	The Wistar Institute is an independent nonprofit biomedical research institute, since 1972, an NCI-designated Cancer Center in basic research. The three complementary research programs at Institute are the Gene Expression and Regulation Program, the Molecular and Cellular Oncogenesis Program, and the Immunology Program.
C39536	Therapeutic_Clinical_Trial	Clinical_Study	Therapeutic Clinical Trial	The Therapeutic Clinical Trial is a controlled clinical study that involves administering of exposure to the agent/agents to subjects with particular disease to elucidate the most appropriate treatment for a specific medical condition, or to prolong or improve the patient's life.
C39537	Therapeutic_Confirmatory_Study	Clinical_Study	Therapeutic Confirmatory Study	The Therapeutic Confirmatory Study is a clinical study that demonstrates or confirms therapy efficacy, establish regimen safety profile and dose-response relationship. The Confirmatory Study provides basis for assessing the risk-benefit relationship to support therapy licensing.
C39538	Therapeutic_Exploratory_Study	Clinical_Study	Therapeutic Exploratory Study	The Therapeutic Exploratory Study is a study that explores the use of the particular medical technology for the targeted indication at the earliest stages of clinical development in well-defined patient populations. The Exploratory Study determines treatment regimen for subsequent studies, and provides basis for confirmatory study design, endpoints, and methodologies.
C39539	Therapeutic_Use_Study	Clinical_Study	Therapeutic Use Study	The Therapeutic Use Study is a clinical study that is conducted with the purpose to refine understanding of therapy risk-benefit relationship in general or special populations and/or environments; to identify less common adverse reactions, and to refine dosing/regimen/indications recommendations.
C39540	Tissue_Culture_Shared_Resource	Clinical_or_Research_Facility	Tissue Culture Shared Resource	The Cell Culture Shared Resource provides Cancer Center investigators with services, technical assistance and expertise in mammalian cell cultures development, maintenance and use including basic support, cell propagation procedures, establishing primary cultures from human and animal tissue samples, cell transformation and screening services, consultation in experimental design, and also provides cells, established cell lines, reagents, and supplies.
C39541	Tissue_Procurement_and_Distribution_Shared_Resource	Clinical_or_Research_Facility	Tissue Procurement and Distribution Shared Resource|Human Tissue Bank Shared Resource	The Tissue Procurement and Distribution Shared Resource provides centralized procurement, storage, and transfer of neoplastic and control human tissues from clinical and surgical pathology, autopsy, and cytology; procurement of physiologic fluids, bone marrow and other specimens for research purposes as requested by Cancer Center investigators, tissue preparation according to the protocol and samples preservation in compliance with rules of the HIC and HIPPA, as well as access to tissues through the Cooperative Human Tissue Network, handling and storing samples, and maintains information on banked samples.
C39542	Toxicology_and_Mutagenesis_Testing_Shared_Resource	Clinical_or_Research_Facility	Toxicology and Mutagenesis Testing Shared Resource	Toxicology and Mutagenesis Testing Shared Resource provides Cancer Center investigators with support and expertise in toxicology and mutagenesis testing of pharmaceuticals, drug candidates, biotechnology products, chemicals, agrochemicals, and other test substances in a variety of assays (e.g. Ames test, E. coli mutation assay, micronucleus and transgenic rodent mutagenesis assays, mammalian cell gene mutation and chromosome aberrations assays) according to the FDA, EPA and MAIR regulatory requirements; and develops new molecular biological techniques allowing detection and characterization of toxic responses at the cellular level.
C39543	Transgenic_and_Mutant_Animals_Shared_Resource	Clinical_or_Research_Facility	Transgenic and Mutant Animals Shared Resource	The Transgenic and Mutant Animals Shared Resource provides development and characterization of biomedically relevant transgenic animal models and knockout experimental animals for Cancer Center members and other investigators. Resource is responsible for maintenance of genetically altered animal lines and germplasm, animal embryo cryopreservation, assisted reproduction techniques, and access to national transgenic animal databases.
C39544	Translational_Cell_Therapy_Shared_Resource	Clinical_or_Research_Facility	Translational Cell Therapy Shared Resource	The Translational Cell Therapy Shared Resource serves as a resource for the members of the Cancer Center interested in basic and pre-clinical research involving human cells, developmental therapies and large-scale production of biologic products. The resource provides support in procurement, selection and manipulation of organ tissue, blood or marrow products including stem cells, cell separation, manipulation, and culture, and the development of large-scale processing of cells for clinical trials.
C39545	Translational_Research_Shared_Resource	Clinical_or_Research_Facility	Translational Research Shared Resource	The Translational Research Shared Resource supports Cancer Center clinical trials by providing infrastructure for laboratory correlate studies. The resource collects, tracks, processes and distributes samples to collaborating laboratories and shared resources, maintains database on samples information, and acts as a resource for investigators during protocol planning by providing information about all aspects of specimen handling.
C39546	Treatment_Effectiveness	Assessment	Treatment Effectiveness	The Treatment Effectiveness is a treatment effect sullied by the context of usual practice, usually determined in non-randomized outcome studies. Effectiveness is a measure of the ability of an intervention to produce the desired beneficial clinical effect in average conditions of use. Could be affected by lack of efficacy and/or patient compliance.
C39547	Treatment_Efficacy	Assessment	Treatment Efficacy	The Treatment Efficacy is the probability of benefit to individuals in a defined population from a medical technology applied for a given medical problem under ideal conditions of use. Efficacy is a measure of effect of therapy among appropriate patients in whom treatment is tolerated and effectively administered, under the condition of sufficient patients' compliance, usually determined in randomized trials.
C39548	University_of_Alabama_at_Birmingham_Cancer_Center	Comprehensive_Cancer_Center	University of Alabama at Birmingham Cancer Center|UAB Comprehensive Cancer Center	The University of Alabama at Birmingham Comprehensive Cancer Center received NCI- designated status in 1973. The Center's research activities are divided into eight major programs: Immunology, Structural Biology, Virology, and Molecular Genetics, Experimental Therapeutics Program, Neuro-Oncology Program, Cancer Control and Population Science Program, Woman's Cancer Program.
C39549	University_of_Chicago_Cancer_Research_Center	Comprehensive_Cancer_Center	University of Chicago Cancer Research Center|UCCRC	The University of Chicago Cancer Research Center is an NCI-designated Comprehensive Cancer Center comprised of seven programs and 14 core resources. This infrastructure provides the opportunity for integrating investigators in the basic, clinical and population sciences with the goal of fostering translational research
C39551	University_of_Michigan_Comprehensive_Cancer_Center	Cancer_Center	University of Michigan Comprehensive Cancer Center	University of Michigan Comprehensive Cancer Center comprised of four basic science programs: Cancer Cell Biology, Cancer Genetics Program, Experimental Therapeutics Program, and Tumor Immunology and Immunotherapy Program; the Cancer Prevention and Control Program with two sub-fields of inquiry: biomedical and socio-behavioral; and ten clinical research programs within the Clinical Science Division at the Cancer Center, and 14 core resources.
C39552	University_of_Minnesota_Cancer_Center	Comprehensive_Cancer_Center	University of Minnesota Cancer Center	The University of Minnesota Cancer Center is an NCI-designated Comprehensive Cancer Center. The Cancer Center sponsors eight research programs: breast cancer, cancer progression and metastasis, carcinogenesis and chemoprevention, genetic mechanisms of cancer, immunology, prevention and etiology, translational research, and transplant biology and therapy. The Cancer Center provides shared resources to its members in areas such as biostatistics, informatics, translational cell therapy, data collection, embryonic stem cell technology, flow cytometry, mass spectrometry, and tissue procurement.
C39553	University_of_Nebraska_Medical_Center_Eppley_Center_for_Cancer_Research_and_Cancer_Care	Cancer_Center	UNMC Eppley Cancer Center|UNMC Eppley Center for Cancer Research and Cancer Care|University of Nebraska Medical Center Eppley Center for Cancer Research and Cancer Care	The University of Nebraska Medical Center/Eppley Cancer Center is an NCI-designated Cancer Center. There are three main research programs at the UNMC Eppley Cancer Center: Developmental Therapeutics, Molecular and Biochemical Etiology of Cancer, and Cancer Biology.
C39554	University_of_North_Carolina_Chapel_Hill_Lineberger_Cancer_Center	Comprehensive_Cancer_Center	UNC Lineberger Comprehensive Cancer Center|University of North Carolina Chapel Hill Lineberger Cancer Center	The University of North Carolina Chapel Hill Lineberger Cancer Center is an NCI-designated Comprehensive Cancer Center. The Center has eleven programs in three major areas: in basic science (Cancer Cell Biology, Immunology, Molecular Carcinogenesis, Genetics, Molecular Therapeutics, and Virology); in clinical science (Clinical Research, Breast Cancer, and Radiobiology and Imaging) encompassing multidisciplinary translational research, clinical trials, and clinical applications of computer science in radiation oncology; and two public health programs (Cancer Prevention and Control and Cancer Epidemiology), and additional SPORE program in breast cancer funded by NCI.
C39555	University_of_Pittsburgh_Cancer_Institute	Comprehensive_Cancer_Center	University of Pittsburgh Cancer Institute|UPCI	The University of Pittsburgh Cancer Institute received the Comprehensive Cancer Center designation from NCI in 1990. Basic research programs include Immunology Program, Molecular and Cellular Oncology Program, Molecular Virology program. The Clinical Investigations division incorporates 14 clinical research programs and the Division of Cancer Control and Population Sciences three programs. The Institute provides 21 shared resources.
C39556	University_of_Southern_California_Norris_Cancer_Center	Comprehensive_Cancer_Center	USC/Norris Comprehensive Cancer Center and Hospital|USC/Norris Comprehensive Cancer Center|University of Southern California Norris Cancer Center	The USC/Norris Comprehensive Cancer Center was recognized by NCI as one of the first eight comprehensive cancer centers in the USA in 1973.
C39557	University_of_Texas_M_D_Anderson_Cancer_Center	Comprehensive_Cancer_Center	University of Texas M D Anderson Cancer Center|MDACC|University of Texas MD Anderson Cancer Center	The University of Texas M. D. Anderson Cancer Center is an NCI-designated Comprehensive Cancer Center. It ranked first in the number of grants awarded nationwide by the NCI in 2002. The Center holds eight NCI-recognized and sponsored Specialized Programs of Research Excellence (SPORE) grants.
C39558	University_of_Virginia_Cancer_Center	Clinical_Cancer_Center	University of Virginia Cancer Center|UVA Cancer Center	The University of Virginia Cancer Center of University of Virginia Health Sciences Center is an NCI-designated Clinical Cancer Center. Research is organized around 7 research programs: Cell Signaling, Endocrinology, Immunology, Migration and Metastasis, Structural Biology, Molecular Genetics, Clinical and Translational Oncology.  The Center includes 10 shared research cores.
C39559	University_of_Wisconsin_Comprehensive_Cancer_Center	Comprehensive_Cancer_Center	University of Wisconsin Comprehensive Cancer Center|UWCC	The University of Wisconsin Cancer Center is an NCI-designated Comprehensive cancer center. Major research programs are: Immunology and Immunotherapy, Imaging and Radiation Science, Cancer Genetics, Cell Signaling and Growth Control, Etiology and Chemoprevention, Experimental Therapeutics, Human Cancer Virology.
C39560	US_Army_Medical_Research_and_Materiel_Command	Other_Agency_or_Organization	US Army Medical Research and Material Command|USAMRMC	The US Army Medical Research and Materiel Command (USAMRMC) is a component of Department of Defense (DOD) managing biomedical research programs that are part of the DOD and Army budget submission. As directed by Congress, the USAMRMC manages congressionally targeted biomedical research programs.
C39561	Vermont_Cancer_Center_at_the_University_of_Vermont	Comprehensive_Cancer_Center	Vermont Cancer Center at the University of Vermont|VCC	Vermont Cancer Center at the University of Vermont is an NCI-designated Comprehensive Cancer Center. Research at the Center is currently organized into four thematic programs: Cancer Prevention and Control, Clinical, Cell Signaling and Growth Control, and Genome Stability and Expression and supported by eight shared resource facilities
C39562	X-ray_Crystallography_Shared_Resource	Clinical_or_Research_Facility	X-ray Crystallography Shared Resource	The X-ray Crystallography Shared Resource provides support to Cancer Center investigators in determination of both small molecule and macromolecular crystal structures, determination of protein structure-function relationships, quantitative analysis of protein crystallography data, X-ray diffraction data, and structure-based approaches to drug design.
C39563	Yale_Cancer_Center	Comprehensive_Cancer_Center	Yale Cancer Center	The comprehensive Cancer Center at the Yale University School of Medicine.
C39564	Health_Care_Visit	Visit	Health Care Visit|Healthcare Visit	A visit by a patient or study participant to a medical professional.
C39565	Coarse_Azurophilic_Granules_Present	Morphologic_Finding	Coarse Azurophilic Granules Present
C39566	Neoplastic_T-Lymphocyte_and_Neoplastic_Natural_Killer_Cell	Neoplastic_Lymphocyte	Neoplastic T-Lymphocyte and Neoplastic Natural Killer Cell
C39567	T-Lymphocyte_and_Natural_Killer_Cell	Lymphocyte	T-Lymphocyte and Natural Killer Cell|T-Lymphocyte and NK-Cell	Group of lymphocytes. A T-lymphocyte is a white blood cell differentiated in the thymus that possesses highly specific cell-surface antigen receptors. A natural killer cell resembles a T-lymphocyte, but it does not express markers of either T or B cell lineage. Its cytotoxic activity is not antibody dependent.
C39568	Peripheral_T-Lymphocyte_and_Natural_Killer_Cell	T-Lymphocyte_and_Natural_Killer_Cell	Peripheral (Post-Thymic) T-Lymphocyte and Natural Killer Cell|Peripheral (Post-Thymic) T-Lymphocyte and NK-Cell
C39569	Cytoplasmic_Protrusions_Present	Morphologic_Finding	Cytoplasmic Protrusions Present|Cytoplasmic Blebs Present
C39570	Cutaneous_Involvement	Integumentary_System_Finding	Cutaneous Involvement
C39571	Neoplastic_Small_T-Prolymphocyte	Neoplastic_Small_T-Lymphocyte|Neoplastic_T-Prolymphocyte	Neoplastic Small T-Prolymphocyte
C39572	Neoplastic_Cerebriform_T-Prolymphocyte	Neoplastic_T-Prolymphocyte	Neoplastic Cerebriform T-Prolymphocyte|Neoplastic Sezary Cell-like Prolymphocyte
C39573	T-Lymphocyte_with_a_Post-Thymic_Immunophenotype	Mature_T-Lymphocyte	T-Lymphocyte with a Post-Thymic Immunophenotype
C39574	Type_1a_Autoimmune_Lymphoproliferative_Syndrome	Autoimmune_Lymphoproliferative_Syndrome	Type 1a Autoimmune Lymphoproliferative Syndrome|Type 1a ALPS
C39575	Type_1b_Autoimmune_Lymphoproliferative_Syndrome	Autoimmune_Lymphoproliferative_Syndrome	Type 1b Autoimmune Lymphoproliferative Syndrome|Type 1b ALPS
C39576	Type_2_Autoimmune_Lymphoproliferative_Syndrome	Autoimmune_Lymphoproliferative_Syndrome	Type 2 Autoimmune Lymphoproliferative Syndrome|Type 2 ALPS
C39577	Type_3_Autoimmune_Lymphoproliferative_Syndrome	Autoimmune_Lymphoproliferative_Syndrome	Type 3 Autoimmune Lymphoproliferative Syndrome|TYpe 3 ALPS
C39578	Autoimmune_Lymphoproliferative_Syndrome-Associated_Lymphoma	Lymphoma	Autoimmune Lymphoproliferative Syndrome-Associated Lymphoma|ALPS-Associated Lymphoma
C39579	FAS_Gene_Mutation	Gene_Abnormality	TNFRSF6 Gene Mutation|FAS Gene Mutation
C39580	FAS_Ligand_Gene_Mutation	Gene_Abnormality	TNFSF6 Gene Mutation|FAS Ligand Gene Mutation
C39581	Casp_8_Gene_Mutation	Gene_Abnormality	CASP8 Gene Mutation|CASP8 Mutation|Casp 8 Gene Mutation
C39582	Casp_10_Gene_Mutation	Gene_Abnormality	CASP10 Gene Mutation|CASP10 Mutation|Casp 10 Gene Mutation
C39583	FAS_Apoptosis_Pathway_Deregulation	Apoptotic_Pathway_Deregulation	FAS Apoptosis Pathway Deregulation|CD95 Apoptotic Pathway Deregulation
C39584	T-Cell_Large_Granular_Lymphocyte_Leukemia_Common_Varianr	T-Cell_Large_Granular_Lymphocyte_Leukemia	T-Cell Large Granular Lymphocyte Leukemia, Common Variant
C39585	T_Gamma-Delta_Lymphocyte	Mature_T-Lymphocyte	Gamma/Delta T-Lymphocyte	A resting, mature T cell that probably plays a primary role in suppressor/cytotoxic phenomena.
C39586	T-Cell_Large_Granular_Lymphocyte_Leukemia_Expressing_the_T-Cell_Receptor_Gamma-Delta	T-Cell_Large_Granular_Lymphocyte_Leukemia	T-Cell Large Granular Lymphocyte Leukemia Expressing the T-Cell Receptor Gamma-Delta|T-Cell Large Granular Lymphocyte Leukemia Expressing the TCR Gamma-Delta
C39587	Xanthine_Dehydrogenase	Oxidoreductase	Xanthine Dehydrogenase|EC 1.1.1.204|EC 1.1.3.22|XDH|Xanthine Oxidase|Xanthine Oxidoreductase	A homodimer, belongs to the family of molybdenum-containing hydroxylases involved in the oxidative metabolism of purines.  Xanthine dehydrogenase can be converted to xanthine oxidase by reversible sulfhydryl oxidation or by irreversible proteolytic modification. Xanthine oxidase (EC 1.1.3.22), a unimolecular, multicomponent electron transport system (with cofactors), catalyzes the oxidation of xanthine to uric acid.  Xanthine dehydrogenase is the mian form exists in liver in vivo.  Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. (NCI)
C39588	Serum_Soluble_Fas_Ligand_Level_Increased	Abnormal_Blood_and_Hematology_Test_Result	Serum Soluble Fas Ligand Level Increased
C39589	Angioinvasion	Morphologic_Finding	Angioinvasion
C39590	XDH_Gene	Oxidoreductase_Gene	XDH Gene|XD|XO|XOR|Xanthine Dehydrogenase Gene	This gene encodes xanthine dehydrogenase, which involved in the oxidative metabolism of purines.  The XDH gene contains 36 exons and spans at least 60 kb.  Its gene product can be converted to xanthine oxidase by reversible or irreversible reactions.  The amino acids sequences involved in both reversible or irreversible conversions are completely conserved between rat and human enzymes.  Defects in xanthine dehydrogenase cause xanthinuria, may contribute to adult respiratory stress syndrome, and may potentiate influenza infection through an oxygen metabolite-dependent mechanism. (NCI)
C39591	Indolent_NK-Cell_Lymphoproliferative_Disorder	Benign_Lymphoproliferative_Disorder	Indolent NK-Cell Lymphoproliferative Disorder|Chronic NK-Cell Lymphocytosis|NK-Cell Large Granular Lymphocyte Lymphocytosis	An Epstein-Barr negative disorder with a nonprogressive clinical course affecting predominantly adults and characterised by the proliferation of large granular lymphocytes with natural killer cell immunophenotype.  The T-cell receptor genes are not rearranged and it is not clear whether this disorder is reactive or neoplastic. -- 2004
C39592	Integrin_Alpha-5	Cell_Adhesion_Molecule	Integrin Alpha 5|CD49e|FNRA|Fibronectin Receptor Alpha Polypeptide|Fibronectin Receptor Alpha Subunit|ITGA5|Integrin Alpha-F|VLA5|VLA5A	Encoded by human ITGA5 Gene (ITGA Family), 1049-aa 114.5-kDa (precursor) type I membrane protein Integrin Alpha 5 contains 7 FG-GAP repeats and is involved in cell adhesion and signaling. Multiple heterodimeric alpha/beta combinations result in different integrins. The Alpha 5 chain undergoes post-translational cleavage of the extracellular domain to yield disulfide-linked heavy and light chains that associate with beta-1 (fibronectin and fibrinogen receptor) or beta-3 and recognize RGD. aV/beta-3 is a receptor for cytotactin, fibronectin, laminin, MMP-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin, and von Willebrand factor. Alpha-5 interacts with HPS5. (NCI)
C39593	Peripheral_Blood_Involvement	Hematopoietic_System_Finding	Peripheral Blood Involvement
C39594	Skin_Rash	Integumentary_System_Signs_and_Symptoms	Skin Rash
C39595	Lactate_Dehydrogenase_Increased	Abnormal_Blood_and_Hematology_Test_Result	Lactate Dehydrogenase Increased|LDH Increased
C39596	CCND2_Gene	Cyclin_Gene	CCND2 Gene|CCND2|Cyclin D2 Gene|KIAK0002	Human cyclin D2 (CCND2) gene, located at 12p13, encodes G1/S-specific cyclin D2 protein. Methylation of the CCND2 promoter region, resulting in decreased cyclin D2 protein levels, has been detected in both gastric and prostate cancers in humans. Conversely, cyclin D2 is overexpressed in human brain tumors, specifically astrocytomas and glioblastomas.
C39597	PRKCB1_Gene	Serine-Threonine_Protein_Kinase_Gene	PRKCB1 Gene|MGC41878|PKC-beta|PKCB|PRKCB|PRKCB1|PRKCB2|Protein Kinase C, Beta 1 Gene	Human PRKCB1 Gene (Ser/Thr PKC Subfamily) encodes 671 aa 77-kDa Protein Kinase C-beta, a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. PRKCB1 may be a component of the NF-kappa-B signaling axis responsible for the survival and activation of B cells after BCR cross-linking. Phosphorylation on Thr-500 of isoform beta-I, within the activation loop, renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol.
C39598	CEBPA_Gene	Transcription_Factor_Gene	CEBPA Gene|C/EBP-alpha|CCAAT/Enhancer Binding Protein (C/EBP), Alpha Gene|CEBP|CEBPA	Human CCAAT/enhancer binding protein, alpha (CEBPA) gene, located at 19q13.1, encodes the alpha form of the CCAAT/enhancer binding protein. Some allelic variants of this gene are associated with acute myeloid leukemia.
C39599	Polylobated_T-Lymphocyte	Pleomorphic_T-Cell	Polylobated T-Lymphocyte|Flower Cell
C39600	Neoplastic_Medium-Sized_T-Lymphocyte	Neoplastic_Medium-Sized_Lymphocyte|Neoplastic_T-Lymphocyte	Neoplastic Medium-Sized T-Lymphocyte
C39601	Pleomorphic_Small_T-Lymphocyte	Neoplastic_Small_T-Lymphocyte|Pleomorphic_T-Cell	Pleomorphic Small T-Lymphocyte
C39602	Pleomorphic_Medium-Sized_to_Large_T-Lymphocyte	Neoplastic_Medium-Sized_to_Large_T-Lymphocyte|Pleomorphic_T-Cell	Pleomorphic Medium-Sized to Large T-Lymphocyte
C39603	Osteoclastic_Activity_Present	Morphologic_Finding	Osteoclastic Activity Present
C39604	Pautrier-like_Microabscess_Present	Morphologic_Finding	Pautrier-Like Microabscess Present
C39605	Neoplastic_Small_T-Lymphocyte	Neoplastic_Small_Lymphocyte|Neoplastic_T-Lymphocyte	Neoplastic Small T-Lymphocyte
C39606	Neoplastic_Small_to_Medium-Sized_T-Lymphocyte	Neoplastic_Small_to_Medium-Sized_Lymphocyte|Neoplastic_T-Lymphocyte	Neoplastic Small to Medium-Sized T-Lymphocyte
C39607	Recombinant_Tissue_Plasminogen_Activator	Thrombolytic_Agent	Recombinant Tissue Plasminogen Activator|Activase|Alteplase|TPA|rt-PA|t-PA	A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, recombinant tPA increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism. (NCI05)
C39608	Coagulative_Necrosis	Necrotic_Change	Coagulative Necrosis
C39609	Activated_Natural-Killer_Cell	Natural_Killer_Cell	Activated Natural Killer Cell	A cell that acts in a similar manner to a cytotoxic T cell. It must be activated like a cytotoxic T cell, but the killing is nonspecific and the cell does not need to recognize antigen/MHC on the target cell. This cell is not a T cell and the lineage of the NK cell is not well understood.
C39610	Small_Intestinal_Enteropathy-Type_T-Cell_Lymphoma	Enteropathy-Type_T-Cell_Lymphoma|Small_Intestinal_Non-Hodgkin_s_Lymphoma	Small Intestinal Enteropathy-Type T-Cell Lymphoma
C39611	Intestinal_Perforation	Perforation	Intestinal Perforation
C39612	Intestinal_Ulcerated_Mass	Intestinal_Mass	Intestinal Ulcerated Mass
C39613	Intraepithelial_T-Lymphocyte_of_the_Intestine	Intraepithelial_T-Lymphocyte	Intraepithelial T-Lymphocyte of the Intestine	A mature T lymphocyte, found in the intestinal lining that differentiates from its precursor outside the thymus, most likely in an area of the gut identified as cryptopatch aggregates. This cell plays a key role in cell-mediated mucosal defense, the down-regulation of immune responses to harmless luminal antigens and in epithelial cell growth and repair.
C39614	Neoplastic_Medium-Sized_to_Large_T-Lymphocyte	Neoplastic_Medium-Sized_to_Large_Lymphocyte|Neoplastic_T-Lymphocyte	Neoplastic Medium-Sized to Large T-Lymphocyte
C39615	Sinusoidal_Infiltration	Morphologic_Finding	Sinusoidal Infiltration
C39616	Karyorrhexis	Morphologic_Finding	Karyorrhexis
C39617	Subcutaneous_Involvement	Integumentary_System_Finding	Subcutaneous Involvement
C39618	Subcutaneous_Nodule	Nodule	Subcutaneous Nodule
C39619	DNA_Vaccine	Vaccine	DNA Vaccine	DNA vaccines are used in vaccination in way that differs from those are designed to be inserted into germ line of vaccines.  Therefore, this is a vaccine not a therapy for modifying genetic information (gene therapy).  Direct innoculation of DNA vaccine causes expression of the recombinant DNA by cells in the inoculated host.  This expression of the recombinant DNA produces protein of interest that promotes antibody, cytolytic T cell and protective immune responses.
C39620	Dermatopathic_Lymphadenopathy	Lymphadenopathy	Dermatopathic Lymphadenopathy
C39621	Cerebriform_Lymphocyte	Neoplastic_T-Lymphocyte	Cerebriform Lymphocyte
C39622	Scaly_Skin_Eruption	Integumentary_System_Signs_and_Symptoms	Scaly Skin Eruption
C39623	Skin_Patches	Integumentary_System_Signs_and_Symptoms	Skin Patch
C39624	Skin_Plaques	Integumentary_System_Signs_and_Symptoms	Skin Plaque
C39625	Extracutaneous_Dissemination_of_Disease	Clinical_Course_of_Disease	Extracutaneous Dissemination of Disease
C39626	Epidermotropic_Lymphocytic_Infiltrate	Lymphocytic_Infiltrate	Epidermotropic Lymphocytic Infiltrate
C39627	Pautrier_Microabscess_Present	Morphologic_Finding	Pautrier Microabscess Present
C39628	Single_Cell_Exocytosis	Morphologic_Finding	Single Cell Exocytosis
C39629	CDKN2A_Gene_Inactivation	Gene_Abnormality	CDKN2A Gene Inactivation|p16/CMM2 Gene Inactivation
C39630	Follicular_Lymphocytic_Infiltrate	Lymphocytic_Infiltrate	Folliculotropic Lymphocytic Infiltrate|Follicular Lymphocytic Infiltrate
C39631	Xp22_1	Chromosome_Band	Xp22.1	A chromosome band present on Xp
C39632	_4q31_1	Chromosome_Band	4q31.1	A chromosome band present on 4q
C39633	_4q31-q32	Chromosome_Band	4q31-q32	A chromosome band present on 4q
C39634	_6p25_3	Chromosome_Band	6p25.3	A chromosome band present on 6p
C39635	_6q25_3	Chromosome_Band	6q25.3	A chromosome band present on 6q
C39636	_6p22_2-p21_3	Chromosome_Band	6p22.2-p21.3	A chromosome band present on 6p
C39637	_7p15_1	Chromosome_Band	7p15.1	A chromosome band present on 7p
C39638	_7q21_3-q22	Chromosome_Band	7q21.3-q22	A chromosome band present on 7q
C39639	_8q24_2-q24_3	Chromosome_Band	8q24.2-q24.3	A chromosome band present on 8q
C39640	Mucinous_Degeneration	Morphologic_Finding	Mucinous Degeneration
C39641	_11q14-q21	Chromosome_Band	11q14-q21	A chromosome band present on 11q
C39642	SOD2_Gene	Oxidoreductase_Gene	SOD2 Gene|MNSOD|SOD2|Superoxide Dismutase 2, Mitochondrial Gene	Human SOD2 Gene (Fe/Mn SOD Family) encodes 222-aa 25-kDa (precursor) Manganese Superoxide Dismutase, a homotetrameric free radical scavenging indophenoloxidase in the mitochondrial matrix that is required for normal cell function. A first line of defense against toxic superoxide radical byproducts of the energy generating oxidative phosphorylation pathway, MnSOD maintains the integrity of mitochondrial respiratory chain enzymes susceptible to inactivation by superoxide. Reactive oxygen species and oxidative stress are implicated in a range of degenerative processes including ALS, ischemic heart disease, Alzheimer disease, Parkinson disease, and aging. Mitochondria are the chief source of reactive oxygen species in the cell. (NCI)
C39643	Elastophagocytosis	Morphologic_Finding	Elastophagocytosis
C39644	Mycosis_Fungoides_Variant	Cutaneous_T-Cell_Lymphoma|Indolent_Non-Hodgkin_s_Lymphoma|Mycosis_Fungoides_and_Sezary_Syndrome	Mycosis Fungoides Variant
C39645	NR3C2_Gene	Nuclear_Receptor_Gene	NR3C2 Gene|MCR|MLR|NR3C2|Nuclear Receptor Subfamily 3, Group C, Member 2 Gene	Highly expressed in kidney and sweat glands, human NR3C2 Gene (NR3 Family) encodes 4 alternative isoforms of ubiquitous phosphorylated Mineralocorticoid Receptor, containing an N-terminal modulating domain, a DNA-binding domain, and a C-terminal steroid (mineralocorticoid/glucocorticoid)-binding domain. Absent ligand, NR3C2 resides in a heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP4 or with HSD11B2 in the ER membrane. Ligand-activated NR3C2 translocates to the nucleus, binds to DNA mineralocorticoid response elements as a homodimer or heterodimer with NR3C1, and transactivates target gene expression, which increases ion and water transport; raises extracellular fluid volume and blood pressure; and lowers potassium levels. NR3C2 appears to bind NCOA1, NCOA2, TIF1, and NRIP1. NR3C2 defects cause PHA1 and early onset hypertension. (NCI)
C39646	Erythroderma	Non-Neoplastic_Skin_Disorder	Erythroderma
C39647	NPY_Gene	Neuropeptide_Gene	NPY Gene|NPY|Neuropeptide Y Gene	Single copy human NPY Gene (NPY Family) encodes 97-aa 11-kDa (precursor) secreted Neuropeptide Y, a 36-aa peptide neuromodulator with sequence homology to peptide YY and PNP. One of the most abundant widespread peptides in the nervous system and found in some adrenal medulla chromaffin cells, NPY is one of the most highly conserved peptides known; only 3 amino acid differences exist between human and shark. Implicated in control of feeding, energy balance, and secretion of GNRH, NPY may also regulate angiogenesis. NPY regulates proliferation of multipotent postnatal neuronal precursor or basal cells by PKC-dependent rapid and transient activation of ERK1/2 MAP kinases (via NPY Y1 receptor subtype). (NCI)
C39648	Lutzner_Cell	Cerebriform_Lymphocyte	Lutzner Cell
C39649	OXT_Gene	Peptide_Hormone_Gene	OXT Gene|OT|OXT|Oxytocin, Prepro- (Neurophysin I) Gene	Expressed in the hypothalamic supraoptic and paraventricular nuclei as an inactive precursor, human OXT Gene (Vasopressin/Oxytocin Family) encodes 125-aa 13-kDa (precursor) secreted Oxytocin (and Neurophysin I), a posterior pituitary nonapeptide hormone specifically bound to carrier protein Neurophysin I. Activated during axon transport to nerve endings, Oxytocin is packaged into neurosecretory vesicles, secreted into the neurohypophyseal bloodstream, and causes smooth muscle contraction in the uterus during parturition and in the mammary gland during lactation. Oxytocin is also involved in cognition, tolerance, adaptation, and complex sexual and maternal behavior, as well as in regulation of water excretion and cardiovascular functions. (NCI)
C39650	SERPINE1_Gene	Proteinase_Inhibitor_Gene	SERPINE1 Gene|PAI|PAI-1|PAI1|PLANH1|SERPINE1|Serine (or Cysteine) Proteinase Inhibitor, Clade E (Nexin, Plasminogen Activator Inhibitor Type 1), Member 1 Gene	Likely expressed primarily in vascular endothelia, single copy 9-exon 12-kb human SERPINE1 Gene (Serpin Family) encodes 402-aa 45-kDa (nonglycosylated, predicted) secreted plasma Plasminogen Activator Inhibitor 1, an acid-stable glycoprotein in plasma, platelets, and endothelia with structural similarity to angiotensinogen, alpha-1-antitrypsin, and antithrombin III. PAI-1 acts as bait for tissue plasminogen activator, urokinase, and protein C; rapid interaction with TPA may regulate fibrinolysis. SERPINE1 defects cause of PAI-1 deficiency. (NCI)
C39651	Proliferation_of_High_Endothelial_Venules_Present	Microvascular_Proliferation	Proliferation of High Endothelial Venules Present
C39652	Proliferation_of_Follicular_Dendritic_Cells_Present	Morphologic_Finding	Proliferation of Follicular Dendritic Cells Present
C39653	SERPINB2_Gene	Proteinase_Inhibitor_Gene	SERPINB2 Gene|PAI2|PLANH2|SERPINB2|Serine (or Cysteine) Proteinase Inhibitor, Clade B (Ovalbumin), Member 2 Gene	Expressed in keratinocytes, monocytes, macrophages, placenta, and trophoblast, human SERPINB2 Gene (Serpin Family) encodes 415-aa 47-kDa (predicted, unglycosylated) cytoplasmic Plasminogen Activator Inhibitor 2, a specific inhibitor of urokinase-type plasminogen activator thought to regulate plasminogen activation in the extravascular compartment and to have a possible role in placental maintenance or embryo development. The primary intracellular distribution of SERPINB2 may also indicate a regulatory role in a protease-dependent cellular process such as apoptosis. (NCI)
C39654	SERPINA5_Gene	Proteinase_Inhibitor_Gene	SERPINA5 Gene|PCI|PLANH3|PROCI|SERPINA5|Serine (or Cysteine) Proteinase Inhibitor, Clade A (Alpha-1 Antiproteinase, Antitrypsin), Member 5 Gene	Expressed in liver, 5-exon 11.5-kb human SERPINA5 Gene (Serpin Family) encodes 406-aa 46-kDa (precursor) secreted plasma Plasminogen Activator Inhibitor 3, an inhibitor of plasminogen activators and activated protein C, a potent vitamin K-dependent anticoagulant serine protease zymogen. (NCI)
C39655	PRL_Gene	Peptide_Hormone_Gene	PRL Gene|PRL|Prolactin Gene	Expressed in anterior pituitary lactotropes (under PIT1 control) and the decidual endometrium, human PRL Gene (Somatotropin/Prolactin Family) encodes 227-aa 26-kDa (precursor) secreted Prolactin, a lactogenic glycoprotein hormone the acts primarily on the mammary gland and in synergy with estrogen induces progesterone release by corpus luteum cells to render the uterine mucosa suited for implantation. (NCI)
C39657	Neoplastic_T-Lymphocyte_with_Clear_Cytoplasm	Neoplastic_T-Lymphocyte	Neoplastic T-Lymphocyte with Clear Cytoplasm
C39658	Bronchiolitis	Non-Neoplastic_Lung_Disorder	Bronchiolitis
C39659	Acute_Bronchiolitis	Bronchiolitis	Acute Bronchiolitis
C39660	PTMA_Gene	Immunoprotein_Gene	PTMA Gene|PTMA|Prothymosin, Alpha (Gene Sequence 28) Gene|TMSA	Human PTMA Gene encodes 110-aa 12-kDa (precursor) highly acidic (54/111 residues) conserved Prothymosin Alpha, which may be linked covalently to a small RNA; may be involved in ultraviolet irradiation-induced apoptosis; contains N-terminal thymosin-alpha-1 (28-aa) sequence; and may mediate immune function and confer resistance to opportunistic infections. While PHAP promotes caspase-9 activation after apoptosome formation, PTMA inhibits apoptosome formation and caspase-9 activation; caspase-3 activator PETCM relieves PTMA inhibition of apoptosome formation. (NCI)
C39661	Chest_Wall_Mass	Mass	Chest Wall Mass|Chest Mass
C39662	SAT_Gene	Transferase_Gene	SAT Gene|SSAT|Spermidine/Spermine N1-Acetyltransferase Gene	Human SAT Gene (TATA-less promoter) encodes 171-aa 20-kDa cytoplasmic Spermidine/Spermine N1-Acetyltransferase, a highly regulated homotetrameric rate-limiting enzyme in the catabolic polyamine metabolism pathway that regulates intracellular polyamine concentration and polyamine transport out of cells. SAT acts on putrescine, spermidine, spermine, N(1)-, and N(8)-acetylspermidine and catalyzes N(1)-acetylation of spermidine and spermine. (NCI)
C39663	Intrauterine_Mass	Mass	Intrauterine Mass|Mass of Uterine Body|Mass of Uterine Corpus|Mass of the Uterine Body|Mass of the Uterine Corpus|Uterine Body Mass|Uterine Corpus Mass
C39664	TAC1_Gene	Neuropeptide_Gene	TAC1 Gene|NK2|NKA|NKNA|TAC1|TAC2|Tachykinin, Precursor 1 (Substance K, Substance P, Neurokinin 1, Neurokinin 2, Neuromedin L, Neurokinin alpha, Neuropeptide K, Neuropeptide gamma) Gene	Human TAC1 Gene (Tachykinin Family) encodes alternative alpha, beta, delta, and gamma isoforms of Preprotachykinin 1 from which arise by proteolytic processing the secreted tachykinins: Substance P, Substance K, Neurokinin A, Neurokinin 2, Neuromedin L, Neurokinin Alpha, Neuropeptide K, and Neuropeptide Gamma. Tachykinins are amidated neuropeptides/neurotransmitters that share C-terminal Phe-X-Gly-Leu-Met sequence; interact with nerve receptors to excite neurons and evoke behavioral responses; are potent vasodilators and secretagogues; and directly or indirectly contract many smooth muscles. Substance P is produced in nociceptive primary sensory neurons and in many brain regions involved in pain signaling. (NCI)
C39665	Tzanck_Cell	Acantholytic_Keratinocyte	Tzanck Cell|Acantholytic Rounded Squamous Cell
C39666	TG_Gene	Structural_Gene	TG Gene|TG|Thyroglobulin Gene	Expressed in thyroid gland (8.7-kb mRNA), 37-exon 300-kb human TG Gene (Type-B Carboxylesterase/Lipase Family) encodes 2768-aa 305-kDa (precursor) Thyroglobulin, a sulfated homodimeric secreted (follicle) glycoprotein containing 11 thyroglobulin type-I domains and precursor of iodinated thyroid hormones triiodothyronine (T3) and thyroxine (T4). Free T4 and T3 hormones are released from hydrolyzed Thyroglobulin. TG defects cause goiter. (NCI)
C39667	Dyskeratotic_Cell	Abnormal_Squamous_Cell	Dyskeratotic Cell
C39668	TRH_Gene	Peptide_Hormone_Gene	TRH Gene|TRH|Thyrotropin-Releasing Hormone Gene	Expressed (highest) in the medial hypothalamic paraventricular nuclei and median eminence, 3-exon 3.3-kb human TRH Gene encodes 242-aa 27-kDa (precursor) (prepro-)Thyrotropin-Releasing Hormone, a major regulator of TSH biosynthesis and release in the anterior pituitary gland and neurotransmitter/neuromodulator in the central and peripheral nervous systems. (NCI)
C39669	TDO2_Gene	Oxidoreductase_Gene	TDO2 Gene|TDO|TPH2|Tryptophan 2,3-Dioxygenase Gene	Human TDO2 Gene encodes 406-aa 48-kDa Tryptophanase, a homotetramer that may bind protoheme IV involved in tryptophan catabolism with broad specificity towards tryptamine and derivatives including tryptophan, 5-hydroxytryptophan, and serotonin. (NCI)
C39670	TYR_Gene	Oxidoreductase_Gene	TYR Gene|TYR|Tyrosinase (Oculocutaneous Albinism IA) Gene	Expression increased after UV-B radiation, 5-exon human TYR Gene (Tyrosinase Family) encodes 2 alternative isoforms of 548-aa 63-kDa Tyrosinase, a type I melanosomal membrane protein and rate-limiting copper-binding oxidase containing glycosylation and histidine-rich sites that catalyzes the first 2 steps, and a subsequent step(s), in tyrosine to DOPA to DOPA-quinone conversion to melanin and formation other polyphenolic compounds. TYR defects cause OCA-IA and OCA-IB. (NCI)
C39671	Dual_Specificity_Phosphatase-22	Dual-Specificity_Phosphoprotein_Phosphatase	Dual Specificity Phosphatase 22|DUSP22|JKAP|JNK-Stimulating Phosphatase 1|JSP1|MKPX|Mitogen-Activated Protein Kinase Phosphatase X	Dual Specificity Phosphatase 22 (184-aa 21-kDa) is encoded by human MKPX Gene. While MAP kinases play a pivotal role in cellular signal transduction, dual-specificity phosphatases can reverse MAP kinase activation by dephosphorylating critical phosphotyrosine and phosphothreonine residues. (NCI)
C39672	Insulin_Receptor-Related_Receptor	Protein_Hormone_Receptor	Insulin Receptor-Related Receptor|INSRR|IR-Related Receptor|IRR|Insulin Receptor-Related Protein	Encoded by human INSRR Gene (Insulin Receptor Family), 1297-aa 144-kDa (precursor) Insulin Receptor-Related Receptor is a type I membrane protein containing 4 fibronectin type III domains, a probable tetramer of disulfide-linked alpha and beta chains, and structurally similar to INSR and IGF1R. The two alpha chains contribute to formation of the ligand-binding domain for an insulin related protein; the two beta chains carry the tyrosine kinase domain. INSRR phosphorylates insulin receptor substrates IRS-1 and IRS-2. (NCI)
C39673	Insulin-Like_Peptide-4	Peptide_Hormone	Insulin-Like Peptide 4|EPIL|Early Placenta Insulin-Like Peptide|INSL4|Placentin	Expressed in fetal perichondrium, uterus, cytotrophoblasts, and syncytiotrophoblasts as a 139-aa 15-kDa precursor by human INSL4 Gene (Insulin Family), Insulin-Like Peptide 4 contains 6 consensus half-cystine residues essential for tertiary structure. The precursor undergoes cleavage to produce A/B/C chains that form tertiary structures of all three chains, or just A and B chains. With insulin-like effects in cell growth control that are not mediated by the INSR, INSL4 may play role in trophoblast development, cell proliferation, differentiation, and bone formation. Acting through membrane tyrosine kinase receptors, INSL growth factors are essential for regulation of energy metabolism, proliferation, and differentiation; intracellular signal transduction pathways invoke a chain of phosphorylation-related events. Chorionic gonadotropin production is increased by INSL4. (NCI)
C39674	Small_Cell_Variant_Anaplastic_Large_Cell_Lymphoma_Giant_Cell_Rich_Subtype	Anaplastic_Large_Cell_Lymphoma	Anaplastic Large Cell Lymphoma, Giant Cell Rich Subtype
C39675	Small_Cell_Variant_Anaplastic_Large_Cell_Lymphoma_Sarcomatoid_Subtype	Anaplastic_Large_Cell_Lymphoma	Anaplastic Large Cell Lymphoma, Sarcomatoid Subtype
C39676	Small_Cell_Variant_Anaplastic_Large_Cell_Lymphoma_Signet_Ring_like_Subtype	Anaplastic_Large_Cell_Lymphoma	Anaplastic Large Cell Lymphoma, Signet Ring-Like Subtype
C39677	Flu-Matrix_Antigen	Vaccine_Antigen	Flu Matrix Antigen
C39678	Anaplastic_T-Cell	Anaplastic_Cell|Neoplastic_T-Lymphocyte	Anaplastic T-Lymphocyte
C39679	Hallmark_Cell	Anaplastic_T-Cell	Hallmark Cell|Anaplastic T-Lymphocyte with Horseshoe-Shaped Nucleus|Anaplastic T-Lymphocyte with Kidney-Shaped Nucleus
C39680	Doughnut_Cell	Anaplastic_T-Cell	Doughnut Cell
C39681	Neoplastic_Small_to_Medium-Sized_T-Lymphocyte_with_Irregular_Nucleus	Neoplastic_Small_to_Medium-Sized_T-Lymphocyte	Neoplastic Small to Medium-Sized T-Lymphocyte with Irregular Nucleus
C39682	Flower-like_T-Lymphocyte	Anaplastic_T-Cell	Flower-Like T-Lymphocyte
C39683	Signet_Ring-like_Neoplastic_T-Lymphocyte	Neoplastic_T-Lymphocyte	Signet Ring-Like Neoplastic T-Lymphocyte
C39684	Jambul	Nutritional_Supplement	Jambul	An herb obtained from the plant Eugenia jambolana.  Jambul seeds and fruits have important carminative and astringent properties and may reduce blood sugar levels.  This agent contains glucosides, jamboline and ellagic acid which may check the conversion of starch into sugar.  Jambul may have chemoprotective and chemopreventive effects. (NCI04)
C39685	Devils_Claw	Nutritional_Supplement	Devils Claw|Devils Foot	An herb obtained from the plant Harpagophytum procumbens.  Devil's claw has been used as a tonic, as a hypoglycemic, to cleanse the lymph system, and in the treatment of arthritis, rheumatism, and skin cancer.  This agent may have anti-inflammatory and analgesic properties, possibly due to the presence of antioxidants, phenols, tannins, triterpenoids and volatile oils. (NCI04)
C39686	Transformed_Skin-Homing_T-Lymphocyte	Activated_Lymphocyte|Mature_T-Lymphocyte	Activated Skin-Homing T-Lymphocyte|Transformed Skin-Homing T-Lymphocyte	A white blood cell, differentiated in the thymus, activated by an antigen that causes the cell to preferentially migrate to the skin.
C39687	Activated_Mature_Cytotoxic_T-Lymphocyte	Mature_Cytotoxic_T-Lymphocyte	Activated Mature Cytotoxic T-Lymphocyte	A white blood cell that is derived from a lymphocyte stem cell matured in the thymus and characterized by a CD8 marker on the surface and an antigen-specific T cell receptor which recognizes antigens in the context of MHC class I.
C39688	Localized_Skin_Lesion	Localized_Lesion	Localized Skin Lesion
C39689	Multicentric_Cutaneous_Involvement	Cutaneous_Involvement	Multicentric Cutaneous Involvement
C39690	Skin_Papules	Integumentary_System_Signs_and_Symptoms|Lesion	Papular Lesion|Skin Papule
C39691	Partial_Spontaneous_Regression	Regression	Partial Spontaneous Regression
C39692	Complete_Spontaneous_Regression	Regression	Complete Spontaneous Regression
C39693	Histiocytic_Infiltrate	Retired_Concepts	Histiocytic Infiltrate
C39694	Sarcomatoid_Features	Morphologic_Finding	Sarcomatoid Features
C39695	Extranodal_Disease	Clinical_Course_of_Disease	Extranodal Disease
C39698	Immune_Response_Regulation_Pathway	Regulatory_Pathways	Immune Response Regulation Pathway
C39699	Apoptosis_Regulation_Pathway	Regulatory_Pathways	Apoptosis Regulation Pathway
C39700	Cell_Cycle_Regulation_Pathway	Regulatory_Pathways	Cell Cycle Regulation Pathway
C39701	Disease_Pathway	Biochemical_Pathway	Disease Pathway
C39702	Degradation_Pathway	Metabolic_Pathways	Degradation Pathway|Degradative Pathway
C39703	Cell_Motility_Pathway	Biochemical_Pathway	Cell Motility Pathway
C39704	Cell_Differentiation_or_Development_Pathway	Biochemical_Pathway	Cell Differentiation or Development Pathway
C39705	DNA_Repair_Pathway	Biochemical_Pathway	DNA Repair Pathway
C39707	Aluminum_Hydroxide	Vaccine_Adjuvant	Aluminum Hydroxide|ALUMINUM HYDROXIDE|Aluminum hydroxide	An inorganic compound containing aluminium.  Used in various immunologic preparations to improve immunogenicity, aluminum hydroxide adjuvant consists of aluminium hydroxide gel in a saline solution.  In vaccines, this agent binds to the protein conjugate, resulting in improved antigen processing by the immune system. (NCI04)
C39708	Cerebriform-like_Lymphocyte	Neoplastic_T-Lymphocyte	Cerebriform-Like Lymphocyte
C39709	Confluent_Sheets_of_Anaplastic_T-Lymphocytes_Present	Abnormal_Cells_Present	Confluent Sheets of Anaplastic T-Lymphocytes Present
C39710	Solitary_Skin_Tumor	Integumentary_System_Finding	Solitary Skin Tumor
C39711	C-KIT_Tyrosine_Kinase_Protein_Overexpression	Protein_Deregulation	C-KIT Tyrosine Kinase Protein Overexpression|CD117 Tyrosine Kinase Protein Overexpression
C39712	C-KIT_Mutation	Oncogene_Deregulation	C-KIT Mutation|CD117 Mutation
C39713	Vitamin_D_Analog	Fat-Soluble_Vitamin	Vitamin D Analog
C39714	DN-101	Vitamin_D_Analog	DN-101|Calcijex|Ro 21-5535|Rocaltrol	An oral high dose formulation of calcitriol, the biologically active form of Vitamin D.  Acting as a ligand for the Vitamin D receptor (VDR), DN-101 binds to the VDR inhibiting VDR-regulated gene transcription involved in cell proliferation, differentiation and apoptosis. (NCI)
C39715	CD30-Positive_Neoplastic_Cells_Present	Positive_Immunophenotypic_Test_Result	CD30-Positive Neoplastic Cells Present|CD30+ Neoplastic Cells Present|Ki-1 Positive Neoplastic Cells Present
C39716	EGFR_Protein_Overexpression	Protein_Deregulation	EGFR Protein Overexpression|Epidermal Growth Factor Receptor Overexpression
C39717	MDM2_Gene_Mutation	Oncogene_Deregulation	MDM2 Gene Mutation|Mouse Double Minute 2 Gene Mutation
C39718	PDGFRalpha_Gene_Mutation	Gene_Abnormality	PDGFRalpha Gene Mutation|Platelet-Derived Growth Factor Receptor Alpha Gene Mutation
C39719	PDGFRalpha_Protein_Overexpression	Protein_Deregulation	PDGFRalpha Protein Overexpression|Platelet-Derived Growth Factor Receptor Alpha Protein Overexpression
C39720	Classical_Reed-Sternberg_Cell	Reed-Sternberg_Cell	Classical Reed-Sternberg Cell
C39721	Abundance_of_Small_Lymphocytes	Morphologic_Finding	Abundance of Small Lymphocytes
C39722	Defective_Heavy_Chain_Present	Abnormal_Blood_and_Hematology_Test_Result	Defective Heavy Chain Present
C39723	Immune_System_Finding	Finding_by_Site_or_System	Immune System Finding
C39725	Immunodeficiency	Immune_System_Finding	Immunodeficiency
C39726	Carbohydrate_Metabolism_Pathway	Metabolic_Pathways	Carbohydrate Metabolism Pathway|Carbohydrate Metabolism - Reference Pathway
C39727	Energy_Metabolism_Pathway	Metabolic_Pathways	Energy Metabolism Pathway|Energy Metabolism - Reference Pathway
C39728	Lipid_Metabolism_Reference_Pathway	Metabolic_Pathways	Lipid Metabolism Reference Pathway|Lipid Metabolism - Reference Pathway
C39729	Nucleotide_Metabolism_Pathway	Metabolic_Pathways	Nucleotide Metabolism Pathway|Nucleotide Metabolism - Reference Pathway
C39730	Amino_Acid_Metabolism_Pathway	Metabolic_Pathways	Amino Acid Metabolism Pathway|Amino Acid Metabolism - Reference Pathway
C39731	Metabolic_Pathways_of_Other_Amino_Acids	Metabolic_Pathways	Metabolic Pathways of Other Amino Acids|Metabolism of Other Amino Acids - Reference Pathway
C39732	Glycan_Biosynthesis_and_Metabolism_Pathway	Metabolic_Pathways	Glycan Biosynthesis and Metabolism Pathway|Glycan Biosynthesis and Metabolism - Reference Pathway
C39733	Cofactors_and_Vitamins_Metabolism_Pathway	Metabolic_Pathways	Cofactors and Vitamins Metabolism Pathway|Metabolism of Cofactors and Vitamins - Reference Pathway
C39734	Biosynthesis_of_Secondary_Metabolites_Pathway	Metabolic_Pathways	Biosynthesis of Secondary Metabolites Pathway|Biosynthesis of Secondary Metabolites - Reference Pathway
C39735	Biodegradation_of_Xenobiotics_Pathway	Degradation_Pathway	Biodegradation of Xenobiotics Pathway|Biodegradation of Xenobiotics
C39736	Genetic_Information_Processing_Pathway	Biochemical_Pathway	Genetic Information Processing Pathway|Genetic Information Processing
C39737	Neurodegenerative_Disorders_Pathway	Disease_Pathway	Neurodegenerative Disorders Pathway|Neurodegenerative Disorders
C39738	Infectious_Disease_Pathway	Disease_Pathway	Infectious Disease Pathway|Infectious Disease
C39739	Negative_Peripheral_Blood	Negative_Test_Result	Negative Peripheral Blood
C39740	Lung_Inflammatory_Myofibroblastic_Tumor	Inflammatory_Myofibroblastic_Tumor|Lung_Soft_Tissue_Neoplasm	Lung Inflammatory Myofibroblastic Tumor
C39741	Retroperitoneal_Inflammatory_Myofibroblastic_Tumor	Inflammatory_Myofibroblastic_Tumor|Retroperitoneal_Neoplasm	Retroperitoneal Inflammatory Myofibroblastic Tumor
C39743	Fascicular_Pattern	Morphologic_Architectural_Pattern	Fascicular Pattern
C39744	Myxoid_Background	Abnormal_Tissue_Present	Myxoid Background
C39745	Sparsely_Cellular_Collagenised_Areas_Present	Morphologic_Finding	Sparsely Cellular Collagenised Areas Present
C39746	Classic_Blastoid_Variant_Mantle_Cell_Lymphoma	Blastoid_Variant_Mantle_Cell_Lymphoma	Classic Blastoid Variant Mantle Cell Lymphoma
C39747	Pleomorphic_Blastoid_Variant_Mantle_Cell_Lymphoma	Blastoid_Variant_Mantle_Cell_Lymphoma	Pleomorphic Blastoid Variant Mantle Cell Lymphoma
C39748	Lymphoblast-like_Neoplastic_B-Lymphocyte	Neoplastic_B-Lymphocyte	Lymphoblast-Like Neoplastic B-Lymphocyte
C39749	Type_II_Endometrial_Adenocarcinoma	Endometrial_Adenocarcinoma	Type II Endometrial Adenocarcinoma|Type II Endometrial Carcinoma
C39750	Primary_Glioblastoma	Glioblastoma	Primary Glioblastoma|Primary Glioblastoma Multiforme	A glioblastoma arising de novo, with no prior evidence of lower grade astrocytoma.  It occurs mostly in older patients and is associated with specific molecular abnormalities, notably epidermal growth factor receptor (EGFR) overexpression and also mouse double minute 2 (MDM2) gene amplification. -- 2004
C39751	Secondary_Glioblastoma	Glioblastoma	Secondary Glioblastoma|Secondary Glioblastoma Multiforme	A glioblastoma arising from a lower grade astrocytoma.  It is more commonly seen in younger patients and is associated with specific molecular abnormalities including TP53 gene mutation, platelet-derived growth factor receptor alpha (PDGFRalpha) gene amplification, and loss of heterozygosity for 19q. -- 2004
C39752	Refractory_Disease	Clinical_Course_of_Disease	Refractory Disease
C39753	Plexiform_Ameloblastoma	Ameloblastoma	Plexiform Ameloblastoma
C39754	Acanthomatous_Ameloblastoma	Ameloblastoma	Acanthomatous Ameloblastoma
C39755	Multicystic_Ameloblastoma	Ameloblastoma	Multicystic Ameloblastoma
C39756	Unicystic_Ameloblastoma	Ameloblastoma	Unicystic Ameloblastoma
C39757	Basal_Cell_Ameloblastoma	Ameloblastoma	Basal Cell Ameloblastoma
C39758	Desmoplastic_Ameloblastoma	Ameloblastoma	Desmoplastic Ameloblastoma
C39760	Above_the_Diaphragm_Disease	Clinical_Course_of_Disease	Above the Diaphragm Disease
C39761	Below_the_Diaphragm_Disease	Clinical_Course_of_Disease	Below the Diaphragm Disease
C39762	Villous_Lymphocytes_not_Present	Morphologic_Finding	Villous Lymphocytes not Present|Villous Lymphocytes Absent
C39763	Neoplastic_Small_Cleaved_Follicle_Center_Cells_not_Present	Morphologic_Finding	Neoplastic Small Cleaved Follicle Center Cells not Present|Neoplastic Small Cleaved Follicle Center Cells Absent
C39765	Gadolinium	Metals	Gadolinium|Gd	An element with atomic symbol Gd, atomic number 64, and atomic weight 157.25.
C39766	Plastic_Surgery_Procedure	Surgical_Procedure	Plastic Surgery Procedure|plastic surgery	An operation that restores or improves the appearance of body structures.
C39767	Contiguous_Disease	Clinical_Course_of_Disease	Contiguous Disease
C39768	Non-Contiguous_Disease	Clinical_Course_of_Disease	Non-Contiguous Disease
C39769	Attempt	Conceptual_Entities	Attempt	An activity intended to do or accomplish something.  Routinely used as in "number of tries to complete a procedure".
C39771	Light_Exercise	Exercise	Light Exercise|Light Activity	Light exercise is defined as 20-60 minutes of exercise which elevates your heart rate to 35-60% of your maximum heart rate performed at least 3-4 times per week.  Your maximum heart rate is approximately 220 minus your age.  Light exercises include housework, gardening, bowling, and slow walking.
C39772	Moderate_Exercise	Exercise	Moderate Exercise|Moderate Activity	Moderate exercise is defined as 20-60 minutes of exercise which elevates your heart rate to 60-80% of your maximum heart rate performed at least 3-4 times per week.  Your maximum heart rate is approximately 220 minus your age.  Moderate exercises include basketball, singles tennis, downhill skiing, and moderate walking.
C39773	Strenuous_Exercise	Exercise	Strenuous Exercise|Strenuous Activity	Strenuous exercise is defined as 20-60 minutes of exercise which elevates your heart rate to 80-90% of your maximum heart rate performed at least 3-4 times per week.  Your maximum heart rate is approximately 220 minus your age.  Strenuous exercises include jogging, swimming, bicycling, and brisk walking.
C39774	Aerobic_Exercise	Exercise	Aerobic Exercise|Aerobic Activity	Brisk physical activity that requires the heart and lungs to work harder to meet the body's increased oxygen demand. Aerobic exercise promotes the circulation of oxygen through the blood.  Examples of aerobic exercise include running, swimming and cycling. (MedicineNet.com)
C39775	HTR2A_Gene	G_Protein-Coupled_Receptor_Gene	HTR2A Gene|5-HT-2A Gene|5-HT2A|5-Hydroxytryptamine (Serotonin) Receptor 2A Gene|5-Hydroxytryptamine Receptor 2A Gene|HTR2|HTR2 Gene|HTR2A|Serotonin 5-HT-2 Receptor Gene	Maternally expressed 20-kb 3-exon human HTR2A Gene (GPCR1/5HT2 Family) encodes 471-aa 53-kDa Serotonin 5-HT-2A Receptor, a conserved integral membrane 5-HT/serotonin receptor protein involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production by association with G proteins that activate a PI-calcium second messenger system. 5-HT is a biogenic hormone that affects specific receptors as a neurotransmitter, hormone, or mitogen. At least 6 types of 5-HT receptors have been identified: 5-HT-1A, -1B, -1C, -1D, -2, and -3. (NCI)
C39776	_13q14-q21	Chromosome_Band	13q14-q21	A chromosome band present on 13q
C39777	Very_Light_Exercise	Exercise	Very Light Exercise|Sedentary Exercise|Very Light Activity	Very light or sedentary exercise is defined as light exercise for less than 20 minutes or 20-60 minutes of exercise which elevates your heart rate to less than 35% of your maximum heart rate or light exercise less than 3 times per week.  Your maximum heart rate is approximately 220 minus your age.
C39778	ADRB1_Gene	Beta_Adrenergic_Receptor_Gene	ADRB1 Gene|ADRB1|ADRB1R|Adrenergic, Beta-1-, Receptor Gene|B1AR|BETA1AR|RHR	Human ADRB1 Gene (GPCR1 Family) encodes conserved 477-aa 51-kDa Beta-1-Adrenergic Receptor, an integral membrane protein receptor for catecholamine epinephrine and norepinephrine neurotransmitters that activates adenylate cyclase through G protein action. ADRB1 phosphorylation by beta-adrenergic receptor kinase mediates receptor desensitization. Agonist and antagonist drugs selective for beta-1 receptors have important applications in clinical medicine. (NCI)
C39779	Maximum_Heart_Rate	Personal_Attribute	Maximum Heart Rate|HR-max	Your maximum heart is approximately 220 minus your age.  Determination of a specific maximum heart rate must consider things like your sex, your general state of fitness, underlying disease, and medications you are taking.
C39780	CETP_Gene	Transport_Protein_Gene	CETP Gene|CETP|Cholesteryl Ester Transfer Protein, Plasma Gene	Expressed in liver human CETP Gene (BPI/LBP Family) encodes 493-aa 55-kDa (precursor) secreted plasma Cholesterol Ester Transfer Protein, involved in the transfer of insoluble cholesteryl esters among lipoproteins in the reverse transport of cholesterol, a vital step in normal cholesterol metabolism and homeostasis. CETP may affect susceptibility to atherosclerosis and CETP defects cause CETP deficiency. (NCI)
C39781	Transcription_Initiation_Factor-IIA	Protein_or_Riboprotein_Complex	Transcription Initiation Factor IIA|General Transcription Factor IIA|TFIIA|Transcription Factor IIA
C39782	Ganglioside_GD3	Ganglioside	Ganglioside GD3|Disialosyllactosylceramide|GD3 ganglioside|N-Acetylneuraminyl N-acetylneuraminylgalactosylglucosylceramide	A liposaccharide disialoganglioside, GD3 is displayed on the surface of most melanomas, soft tissue sarcomas and tumors of neuroectodermal origin, while normal tissues display little or no GD3.(NCI)
C39783	Retinal_Hemangioblastoma	Hemangioblastoma|Retinal_Neoplasm	Retinal Capillary Hemangioblastoma|Retinal Hemangioblastoma
C39784	Inner_Ear_Neoplasm	Ear_Neoplasm	Inner Ear Neoplasm
C39786	Bilateral_Disease	Clinical_Course_of_Disease	Bilateral Disease
C39787	Multiple_Tumor_Masses	Neoplastic_Growth_or_Spread	Multiple Tumor Masses
C39788	MET_Gene_Mutation	Oncogene_Deregulation	c-met Gene Mutation
C39789	Hereditary_Renal_Cell_Carcinoma	Familial_Cancer|Renal_Cell_Carcinoma	Hereditary Renal Cell Carcinoma
C39790	Renal_Cell_Carcinoma_with_Constitutional_Chromosome_3_Translocations	Hereditary_Renal_Cell_Carcinoma	Renal Cell Carcinoma with Constitutional Chromosome 3 Translocations
C39791	t_3_8_p14_q24	Chromosomal_Translocation	t(3;8)(p14;q24)
C39792	t_3_6_p13_q25	Chromosomal_Translocation	t(3;6)(p13;q25)
C39793	t_3_12_q13_q24	Chromosomal_Translocation	t(3;12)(q13;q24)
C39794	Philosophy	Social_Sciences	Philosophy	The field of study concerned with the rational investigation of questions about existence and knowledge and ethics.
C39795	Loss_of_Chromosome_14q	Chromosomal_Loss	Loss of Chromosome 14q
C39796	Ethics	Philosophy	Ethics	The philosophical study of moral values and rules.  Ethics is a general term for what is often described as the "science of morality". The Western tradition of ethics is sometimes called moral philosophy. This is one of the three major branches of philosophy, alongside metaphysics and logic. (from Wikipedia)
C39797	Gain_of_Chromosome_17p	Chromosomal_Gain	Gain of Chromosome 17p
C39798	Loss_of_Chromosome_2	Chromosomal_Loss	Loss of Chromosome 2
C39799	Loss_of_Chromosome_21	Chromosomal_Loss	Loss of Chromosome 21
C39800	Sickle_Cell_Trait	Hemoglobinopathy	Sickle Cell Trait
C39801	inv_X_p11_q12	Chromosomal_Inversion	inv(X)(p11;q12)
C39802	Renal_Cell_Carcinoma_with_inv_X_p11_q12	Xp11_Translocation-Related_Renal_Cell_Carcinoma	Renal Cell Carcinoma Associated with inv(X)(p11;q12)
C39803	PRCC-TFE3_Fusion_Protein_Expression	Fusion_Protein_Expression	PRCC-TFE3 Fusion Protein Expression
C39805	PSF-TFE3_Fusion_Protein_Expression	Fusion_Protein_Expression	PSF-TFE3 Fusion Protein Expression
C39806	NONO-TFE3_Fusion_Protein_Expression	Fusion_Protein_Expression	NONO-TFE3 Fusion Protein Expression
C39807	Mucinous_Tubular_and_Spindle_Renal_Cell_Carcinoma	Renal_Cell_Carcinoma	Mucinous Tubular and Spindle Renal Cell Carcinoma
C39808	Asymptomatic_Mass	Mass	Asymptomatic Mass
C39809	Type_1_Papillary_Adenoma_of_the_Kidney	Papillary_Adenoma	Type 1 Renal Papillary Adenoma|Type 1 Papillary Adenoma of the Kidney
C39810	Type_2_Papillary_Adenoma_of_the_Kidney	Papillary_Adenoma	Type 2 Renal Papillary Adenoma|Type 2 Papillary Adenoma of the Kidney
C39811	t_5_11_q35_q13	Chromosomal_Translocation	t(5;11)(q35;q13)
C39812	Metanephric_Adenofibroma	Benign_Renal_Neoplasm|Fibroepithelial_Neoplasm	Metanephric Adenofibroma
C39813	hSNF5_INI1_Tumor_Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	SMARCB1 Gene Inactivation|hSNF5/INI1 Gene Inactivation|hSNF5/INI1 Tumor Suppressor Gene Inactivation
C39814	Childhood_Classic_Congenital_Mesoblastic_Nephroma	Childhood_Congenital_Mesoblastic_Nephroma	Classic Congenital Mesoblastic Nephroma
C39815	Childhood_Cellular_Congenital_Mesoblastic_Nephroma	Childhood_Congenital_Mesoblastic_Nephroma	Cellular Congenital Mesoblastic Nephroma
C39816	Infiltrating_Bladder_Urothelial_Carcinoma_with_Squamous_Differentiation	Invasive_Urothelial_Transitional_Cell_Carcinoma	Infiltrating Bladder Urothelial Carcinoma with Squamous Differentiation
C39817	Infiltrating_Bladder_Urothelial_Carcinoma_with_Glandular_Differentiation	Invasive_Urothelial_Transitional_Cell_Carcinoma	Infiltrating Bladder Urothelial Carcinoma with Glandular Differentiation
C39818	Infiltrating_Bladder_Urothelial_Carcinoma_with_Trophoblastic_Differentiation	Invasive_Urothelial_Transitional_Cell_Carcinoma	Infiltrating Bladder Urothelial Carcinoma with Trophoblastic Differentiation
C39819	Infiltrating_Bladder_Urothelial_Carcinoma_Nested_Variant	Invasive_Urothelial_Transitional_Cell_Carcinoma	Infiltrating Bladder Urothelial Carcinoma, Nested Variant
C39820	Infiltrating_Bladder_Urothelial_Carcinoma_Microcystic_Variant	Invasive_Urothelial_Transitional_Cell_Carcinoma	Infiltrating Bladder Urothelial Carcinoma, Microcystic Variant
C39821	Infiltrating_Bladder_Lymphoepithelioma-like_Carcinoma	Invasive_Urothelial_Transitional_Cell_Carcinoma|Lymphoepithelioma-Like_Carcinoma	Infiltrating Bladder Lymphoepithelioma-Like Carcinoma
C39822	Infiltrating_Bladder_Urothelial_Carcinoma_Lymphoma-like_Variant	Invasive_Urothelial_Transitional_Cell_Carcinoma	Infiltrating Bladder Urothelial Carcinoma, Lymphoma-Like Variant
C39823	Infiltrating_Bladder_Urothelial_Carcinoma_Plasmacytoid_Variant	Invasive_Urothelial_Transitional_Cell_Carcinoma	Infiltrating Bladder Urothelial Carcinoma, Plasmacytoid Variant
C39824	Infiltrating_Bladder_Urothelial_Carcinoma_Sarcomatoid_Variant	Invasive_Urothelial_Transitional_Cell_Carcinoma|Sarcomatoid_Transitional_Cell_Carcinoma	Infiltrating Bladder Urothelial Carcinoma Sarcomatoid Variant
C39825	Infiltrating_Bladder_Urothelial_Carcinoma_Sarcomatoid_Variant_with_Heterologous_Elements	Infiltrating_Bladder_Urothelial_Carcinoma_Sarcomatoid_Variant	Infiltrating Bladder Urothelial Carcinoma, Sarcomatoid Variant with Heterologous Elements
C39826	Infiltrating_Bladder_Urothelial_Carcinoma_Sarcomatoid_Variant_without_Heterologous_Elements	Infiltrating_Bladder_Urothelial_Carcinoma_Sarcomatoid_Variant	Infiltrating Bladder Urothelial Carcinoma, Sarcomatoid Variant without Heterologous Elements
C39827	Infiltrating_Bladder_Urothelial_Carcinoma_Clear_Cell_Variant	Invasive_Urothelial_Transitional_Cell_Carcinoma	Infiltrating Bladder Urothelial Carcinoma, Clear Cell Variant	An invasive transitional cell carcinoma of the bladder characterized by the presence of clear cells.
C39828	Infiltrating_Bladder_Urothelial_Carcinoma_Lipid_Cell_Variant	Invasive_Urothelial_Transitional_Cell_Carcinoma	Infiltrating Bladder Urothelial Carcinoma, Lipid-Cell Variant
C39829	Infiltrating_Bladder_Urothelial_Carcinoma_with_Giant_Cells	Invasive_Urothelial_Transitional_Cell_Carcinoma	Infiltrating Bladder Urothelial Carcinoma with Giant Cells
C39830	Non-Invasive_Bladder_Urothelial_Carcinoma	Bladder_Urothelial_Carcinoma|Intraurothelial_Neoplasia	Non-Invasive Bladder Urothelial Carcinoma
C39831	Non-Invasive_Bladder_Papillary_Urothelial_Neoplasm	Bladder_Papillary_Urothelial_Neoplasm	Non-Invasive Bladder Papillary Urothelial Neoplasm
C39832	Bladder_Verrucous_Squamous_Cell_Carcinoma	Bladder_Squamous_Cell_Carcinoma|Verrucous_Carcinoma	Bladder Verrucous Carcinoma|Bladder Verrucous Squamous Cell Carcinoma
C39833	Schistosoma_Hematobium-Related_Bladder_Verrucous_Squamous_Cell_Carcinoma	Bladder_Verrucous_Squamous_Cell_Carcinoma|Schistosoma_Hematobium-Related_Bladder_Squamous_Cell_Carcinoma	Schistosoma Hematobium-Related Bladder Verrucous Carcinoma|Schistosoma Hematobium-Related Bladder Verrucous Squamous Cell Carcinoma
C39834	Bladder_Squamous_Cell_Papilloma	Benign_Bladder_Neoplasm|Squamous_Cell_Papilloma	Bladder Squamous Papilloma
C39835	Bladder_Enteric_Type_Adenocarcinoma	Bladder_Adenocarcinoma	Bladder Enteric Type Adenocarcinoma|Bladder Colonic Type Adenocarcinoma
C39836	Bladder_Adenocarcinoma_not_Otherwise_Specified	Bladder_Adenocarcinoma	Bladder Adenocarcinoma, Not Otherwise Specified|Bladder Adenocarcinoma NOS|Bladder Adenocarcinoma, NOS
C39837	Bladder_Mucinous_Adenocarcinoma	Bladder_Adenocarcinoma|Mucinous_Adenocarcinoma	Bladder Mucinous Adenocarcinoma|Bladder Colloid Adenocarcinoma
C39838	Bladder_Hepatoid_Adenocarcinoma	Bladder_Adenocarcinoma	Bladder Hepatoid Adenocarcinoma
C39839	Bladder_Mixed_Adenocarcinoma	Bladder_Adenocarcinoma	Bladder Mixed Adenocarcinoma
C39840	Urinary_Tract_Precancerous_Condition	Precancerous_Condition_by_Site	Urinary Tract Precancerous Condition
C39841	Intestinal_Metaplasia_of_Bladder_Urothelium	Bladder_Disorder|Urinary_Tract_Precancerous_Condition	Intestinal Metaplasia of Bladder Urothelium
C39842	Bladder_Urachal_Carcinoma	Bladder_Carcinoma	Bladder Urachal Carcinoma
C39843	Bladder_Urachal_Adenocarcinoma	Bladder_Adenocarcinoma|Bladder_Urachal_Carcinoma	Bladder Urachal Adenocarcinoma
C39844	Bladder_Urachal_Urothelial_Carcinoma	Bladder_Urachal_Carcinoma|Bladder_Urothelial_Carcinoma	Bladder Urachal Urothelial Carcinoma
C39845	Bladder_Urachal_Squamous_Cell_Carcinoma	Bladder_Squamous_Cell_Carcinoma|Bladder_Urachal_Carcinoma	Bladder Urachal Squamous Cell Carcinoma
C39846	Intestinal_Metaplasia_of_Bladder_Urachal_Epithelium	Urinary_Tract_Precancerous_Condition	Intestinal Metaplasia of Bladder Urachal Epithelium
C39847	Bladder_Tubulo-Cystic_Clear_Cell_Adenocarcinoma	Bladder_Clear_Cell_Adenocarcinoma	Bladder Tubulo-Cystic Clear Cell Adenocarcinoma	A rare morphologic variant of bladder carcinoma characterized by the presence of malignant glandular epithelial cells and clear cells forming a tubulo-cystic pattern.
C39848	Bladder_Papillary_Clear_Cell_Adenocarcinoma	Bladder_Clear_Cell_Adenocarcinoma	Bladder Papillary Clear Cell Adenocarcinoma	A rare morphologic variant of bladder adenocarcinoma characterized by the presence of malignant glandular epithelial cells and clear cells forming a papillary pattern.
C39849	Bladder_Diffuse_Clear_Cell_Adenocarcinoma	Bladder_Clear_Cell_Adenocarcinoma	Bladder Diffuse Clear Cell Adenocarcinoma	A rare morphologic variant of bladder adenocarcinoma characterized by the presence of malignant glandular epithelial cells and clear cells forming a diffuse pattern.
C39850	Stage_0_Renal_Pelvis_and_Ureter_Carcinoma	Renal_Pelvis_and_Ureter_Carcinoma	Stage 0 Renal Pelvis and Ureter Carcinoma
C39851	Bladder_Urothelial_Carcinoma	Bladder_Carcinoma|Common_Carcinoma|Urothelial_Transitional_Cell_Carcinoma	Bladder Urothelial Carcinoma|Bladder Transitional Cell Carcinoma|Transitional Cell Carcinoma of the Urinary Bladder|Urinary Bladder Transitional Cell Carcinoma|Urinary Bladder Urothelial Carcinoma|Urothelial Carcinoma of the Urinary Bladder
C39852	Urothelial_Neoplasm	Transitional_Cell_Neoplasm|Urinary_Tract_Neoplasm	Urothelial Neoplasm|Transitional Cell Neoplasm of the Urinary Tract
C39853	Infiltrating_Urothelial_Carcinoma	Urothelial_Transitional_Cell_Carcinoma	Infiltrating Urothelial Carcinoma|Infiltrating Transitional Cell Carcinoma of the Urinary Tract
C39854	Non-Invasive_Urothelial_Neoplasm	Urothelial_Neoplasm	Non-Invasive Urothelial Neoplasm|Non-Invasive Transitional Cell Neoplasm of the Urinary Tract
C39855	Diffuse_Leiomyomatosis_Syndrome	Syndrome	Diffuse Leiomyomatosis Syndrome
C39856	Urothelial_Dysplasia	Dysplasia	Urothelial Dysplasia|Transitional Cell Dysplasia of the Urinary Tract
C39857	Bladder_Papillary_Urothelial_Neoplasm	Bladder_Neoplasm|Papillary_Urothelial_Neoplasm	Bladder Papillary Urothelial Neoplasm|Bladder Papillary Transitional Cell Neoplasm|Urinary Bladder Papillary Transitional Cell Neoplasm|Urinary Bladder Papillary Urothelial Neoplasm
C39858	Bladder_Urothelial_Papilloma	Benign_Bladder_Neoplasm|Non-Invasive_Bladder_Papillary_Urothelial_Neoplasm|Urothelial_Papilloma	Bladder Urothelial Papilloma|Bladder Transitional Cell Papilloma|Urinary Bladder Transitional Cell Papilloma|Urinary Bladder Urothelial Papilloma
C39859	Bladder_Inverted_Papilloma	Bladder_Urothelial_Papilloma|Inverted_Urothelial_Papilloma	Bladder Inverted Papilloma|Urinary Bladder Inverted Papilloma
C39860	Cystitis_Glandularis	Chronic_Cystitis	Cystitis Glandularis
C39861	Urethral_Diverticulum	Diverticulum	Urethral Diverticulum
C39862	Human_Papilloma_Virus-Related_Urethral_Squamous_Cell_Carcinoma	Human_Papilloma_Virus-Related_Squamous_Cell_Carcinoma|Urethral_Squamous_Cell_Carcinoma	Human Papilloma Virus-Related Urethral Squamous Cell Carcinoma
C39863	Carcinoma_of_Skene_Glands	Female_Urethral_Malignant_Neoplasm|Paraurethral_Gland_Carcinoma	Carcinoma of Skene Glands
C39864	Carcinoma_of_Cowper_Glands	Male_Urethral_Malignant_Neoplasm|Paraurethral_Gland_Carcinoma	Carcinoma of Cowper Glands
C39865	Carcinoma_of_Littre_Glands	Male_Urethral_Malignant_Neoplasm|Paraurethral_Gland_Carcinoma	Carcinoma of Littre Glands
C39866	Female_Urethral_Malignant_Neoplasm	Malignant_Urethral_Neoplasm	Female Urethral Malignant Neoplasm
C39867	Male_Urethral_Malignant_Neoplasm	Malignant_Urethral_Neoplasm	Male Urethral Malignant Neoplasm
C39868	Penile_Urethral_Malignant_Neoplasm	Male_Urethral_Malignant_Neoplasm	Penile Urethral Malignant Neoplasm
C39869	Bulbomembranous_Urethral_Malignant_Neoplasm	Male_Urethral_Malignant_Neoplasm	Bulbomembranous Urethral Malignant Neoplasm
C39870	Prostatic_Urethral_Malignant_Neoplasm	Male_Urethral_Malignant_Neoplasm	Prostatic Urethral Malignant Neoplasm
C39871	Urethral_Caruncle	Non-Neoplastic_Urethra_Disorder	Urethral Caruncle
C39872	Urethral_Villous_Adenoma	Urethra_Neoplasm	Urethral Villous Adenoma
C39873	Urethral_Glandular_Metaplasia	Urinary_Tract_Precancerous_Condition	Urethral Glandular Metaplasia
C39874	Urethral_Verrucous_Carcinoma	Urethral_Squamous_Cell_Carcinoma|Verrucous_Carcinoma	Urethral Verrucous Carcinoma
C39875	Loss_of_Chromosome_9q	Chromosomal_Loss	Loss of Chromosome 9q
C39877	FGFR3_Gene_Mutation	Gene_Abnormality	FGFR3 Gene Mutation
C39878	Bladder_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Bladder_Lymphoma|Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue	Bladder Mucosa-Associated Lymphoid Tissue Lymphoma|Bladder MALT Lymphoma
C39879	Infiltrating_Renal_Pelvis_and_Ureter_Urothelial_Carcinoma	Infiltrating_Urothelial_Carcinoma|Transitional_Cell_Carcinoma_of_the_Renal_Pelvis_and_Ureter	Infiltrating Renal Pelvis and Ureter Urothelial Carcinoma|Infiltrating Renal Pelvis and Ureter Transitional Cell Carcinoma
C39880	Acinar_Prostate_Adenocarcinoma_Atrophic_Variant	Acinar_Prostate_Adenocarcinoma	Acinar Prostate Adenocarcinoma, Atrophic Variant
C39881	Acinar_Prostate_Adenocarcinoma_Pseudohyperplastic_Variant	Acinar_Prostate_Adenocarcinoma	Acinar Prostate Adenocarcinoma, Pseudohyperplastic Variant
C39882	Acinar_Prostate_Adenocarcinoma_Foamy_Gland_Variant	Acinar_Prostate_Adenocarcinoma	Acinar Prostate Adenocarcinoma, Foamy Gland Variant
C39884	Acinar_Prostate_Adenocarcinoma_Oncocytic_Variant	Acinar_Prostate_Adenocarcinoma	Acinar Prostate Adenocarcinoma, Oncocytic Variant
C39885	Acinar_Prostate_Adenocarcinoma_Lymphoepithelioma-like_Variant	Acinar_Prostate_Adenocarcinoma|Lymphoepithelioma-Like_Carcinoma	Acinar Prostate Adenocarcinoma, Lymphoepithelioma-Like Variant
C39887	High-Grade_Prostatic_Intraepithelial_Neoplasia_Signet_Ring_Variant	High-Grade_Prostatic_Intraepithelial_Neoplasia	High Grade Prostatic Intraepithelial Neoplasia, Signet Ring Variant
C39888	High-Grade_Prostatic_Intraepithelial_Neoplasia_Mucinous_Variant	High-Grade_Prostatic_Intraepithelial_Neoplasia	High Grade Prostatic Intraepithelial Neoplasia, Mucinous Variant
C39889	High-Grade_Prostatic_Intraepithelial_Neoplasia_Foamy_Variant	High-Grade_Prostatic_Intraepithelial_Neoplasia	High Grade Prostatic Intraepithelial Neoplasia, Foamy Variant
C39890	High-Grade_Prostatic_Intraepithelial_Neoplasia_Inverted_Variant	High-Grade_Prostatic_Intraepithelial_Neoplasia	High Grade Prostatic Intraepithelial Neoplasia, Inverted Variant
C39891	High-Grade_Prostatic_Intraepithelial_Neoplasia_Small_Cell_Neuroendocrine_Variant	High-Grade_Prostatic_Intraepithelial_Neoplasia	High Grade Prostatic Intraepithelial Neoplasia, Small Cell Neuroendocrine Variant
C39894	Dideaza-5_6_7_8-Tetrahydrofolic_Acid	Folate_Antagonist|Glycinamide_Ribonucleotide_Formyltransferase_Inhibitor	Dideaza-5,6,7,8-Tetrahydrofolic Acid|DDATHF	An antimetabolite (folate analogue) that inhibits glycinamide ribonucleotide formyltransferase (GARFT) an enzyme involved in de novo purine biosynthesis. (NCI)
C39895	Prostate_Ductal_Adenocarcinoma_Cribriform_Pattern	Prostate_Ductal_Adenocarcinoma	Prostate Ductal Adenocarcinoma, Cribriform Pattern
C39896	Prostate_Ductal_Adenocarcinoma_Papillary_Pattern	Prostate_Ductal_Adenocarcinoma	Prostate Ductal Adenocarcinoma, Papillary Pattern
C39897	Prostate_Ductal_Adenocarcinoma_Solid_Pattern	Prostate_Ductal_Adenocarcinoma	Prostate Ductal Adenocarcinoma, Solid Pattern
C39898	Primary_Prostate_Urothelial_Carcinoma	Prostate_Transitional_Cell_Carcinoma	Primary Prostate Urothelial Carcinoma
C39899	Secondary_Prostate_Urothelial_Carcinoma	Metastatic_Neoplasm_to_the_Prostate	Secondary Prostate Urothelial Carcinoma
C39900	Prostatic_Urethra_Urothelial_Carcinoma	Primary_Prostate_Urothelial_Carcinoma|Prostatic_Urethral_Malignant_Neoplasm|Urethral_Transitional_Cell_Carcinoma	Prostatic Urethra Urothelial Carcinoma
C39901	Prostatic_Duct_Urothelial_Carcinoma	Primary_Prostate_Urothelial_Carcinoma	Prostatic Duct Urothelial Carcinoma
C39902	Prostate_Basal_Cell_Carcinoma	Malignant_Basal_Cell_Neoplasm|Prostate_Carcinoma	Prostate Basal Cell Carcinoma|Basal Cell Carcinoma of the Prostate
C39903	Prostate_Adenocarcinoma_with_Focal_Neuroendocrine_Differentiation	Prostate_Adenocarcinoma	Prostate Adenocarcinoma with Focal Neuroendocrine Differentiation
C39904	Tumor_of_Specialized_Prostatic_Stroma	Prostate_Neoplasm|Stromal_Neoplasm	Tumor of Specialized Prostatic Stroma
C39905	Prostate_Stromal_Proliferation_of_Uncertain_Malignant_Potential	Intermediate_Soft_Tissue_Neoplasm|Male_Reproductive_System_Precancerous_Condition|Tumor_of_Specialized_Prostatic_Stroma	Prostate Stromal Proliferation of Uncertain Malignant Potential|STUMP
C39906	Seminal_Vesicle_Adenocarcinoma	Adenocarcinoma|Malignant_Male_Reproductive_System_Neoplasm|Seminal_Vesicle_Neoplasm	Seminal Vesicle Adenocarcinoma
C39907	Seminal_Vesicle_Cystadenoma	Benign_Male_Reproductive_System_Neoplasm|Cystadenoma|Seminal_Vesicle_Neoplasm	Seminal Vesicle Cystadenoma
C39908	Seminal_Vesicle_Neoplasm	Male_Reproductive_System_Neoplasm	Seminal Vesicle Neoplasm
C39909	Gain_of_Chromosome_18q	Chromosomal_Gain	Gain of Chromosome 18q
C39910	Gain_of_Chromosome_Y	Chromosomal_Gain	Gain of Chromosome Y
C39911	Testicular_Gonadoblastoma	Gonadoblastoma|Testicular_Mixed_Germ_Cell-Sex_Cord-Stromal_Tumor	Testicular Gonadoblastoma
C39912	Testicular_Mixed_Germ_Cell-Sex_Cord-Stromal_Tumor_Unclassified	Testicular_Mixed_Germ_Cell-Sex_Cord-Stromal_Tumor	Testicular Mixed Germ Cell-Sex Cord-Stromal Tumor, Unclassified
C39913	i_12p	Isochromosome	i(12p)|isochromosome 12p
C39914	Gain_of_Chromosome_12p	Chromosomal_Gain	Gain of Chromosome 12p
C39915	Pure_Testicular_Germ_Cell_Tumor	Testicular_Germ_Cell_Neoplasm	Testicular Pure Germ Cell Tumor
C39916	_7p21_2	Chromosome_Band	7p21.2	A chromosome band present on 7p
C39917	TWIST1_Gene	Transcription_Factor_Gene	TWIST1 Gene|ACS3|BPES2|BPES3|SCS|TWIST|TWIST1|Twist Homolog 1 (Acrocephalosyndactyly 3; Saethre-Chotzen Syndrome) (Drosophila) Gene	Expressed in placenta and a subset of adult mesodermal tissues, human TWIST1 Gene (bHLH Family) encodes 202-aa 21-kDa Twist Related Protein 1, a probable homodimeric nuclear bHLH transcription factor containing a bHLH domain, with similarity to Dermo1, and implicated in negative regulation of cell determination and differentiation in myogenic, osteogenic, and neurogenic lineages. Efficient DNA binding requires dimerization with another bHLH protein. TWIST1 inhibits myogenesis by sequestering E proteins, inhibiting transactivation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction probably involving the basic domains of both proteins. TWIST1 also represses expression of proinflammatory cytokines, such as TNFA and IL1B. TWIST1 defects cause Saethre-Chotzen syndrome, Robinow-Sorauf syndrome, and Baller-Gerold syndrome. (NCI)
C39918	Twist_Related_Protein-1	Transcription_Factor	Twist Related Protein 1|Acrocephalosyndactyly 3 Protein|H-Twist|TWIST|TWIST1|TWIST1 Protein|Twist Homolog|Twist Homolog 1	Expressed in placenta and a subset of adult mesodermal tissues by human TWIST1 Gene (bHLH Family), 202-aa 21-kDa Twist Related Protein 1 is a probable homodimeric nuclear bHLH transcription factor containing a bHLH domain, with similarity to Dermo1, and implicated in negative regulation of cell determination and differentiation in myogenic, osteogenic, and neurogenic lineages. Efficient DNA binding requires dimerization with another bHLH protein. TWIST1 inhibits myogenesis by sequestering E proteins, inhibiting transactivation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction probably involving the basic domains of both proteins. TWIST1 also represses expression of proinflammatory cytokines, such as TNFA and IL1B. TWIST1 defects cause Saethre-Chotzen syndrome, Robinow-Sorauf syndrome, and Baller-Gerold syndrome. (NCI)
C39919	Testicular_Seminoma_with_Syncytiotrophoblastic_Cells	Testicular_Seminoma	Testicular Seminoma with Syncytiotrophoblastic Cells
C39920	Testicular_Seminoma_with_High_Mitotic_Index	Testicular_Seminoma	Testicular Seminoma with High Mitotic Index|Anaplastic Seminoma|Atypical Seminoma
C39921	Testicular_Spermatocytic_Seminoma	Spermatocytic_Seminoma|Testicular_Seminoma	Testicular Spermatocytic Seminoma
C39922	Testicular_Spermatocytic_Seminoma_with_Sarcoma	Testicular_Spermatocytic_Seminoma	Testicular Spermatocytic Seminoma with Sarcoma
C39923	Testicular_Yolk_Sac_Tumor_Microcystic_Pattern	Testicular_Yolk_Sac_Tumor	Testicular Yolk Sac Tumor, Microcystic Pattern|Testicular Yolk Sac Tumor, Reticular Pattern
C39924	Testicular_Yolk_Sac_Tumor_Macrocystic_Pattern	Testicular_Yolk_Sac_Tumor	Testicular Yolk Sac Tumor, Macrocystic Pattern
C39925	Testicular_Yolk_Sac_Tumor_Solid_Pattern	Testicular_Yolk_Sac_Tumor	Testicular Yolk Sac Tumor, Solid Pattern
C39926	Testicular_Yolk_Sac_Tumor_Glandular-Alveolar_Pattern	Testicular_Yolk_Sac_Tumor	Testicular Yolk Sac Tumor, Glandular-Alveolar Pattern
C39927	Testicular_Yolk_Sac_Tumor_Endodermal_Sinus_Pattern	Testicular_Yolk_Sac_Tumor	Testicular Yolk Sac Tumor, Endodermal Sinus Pattern
C39928	Testicular_Yolk_Sac_Tumor_Papillary_Pattern	Testicular_Yolk_Sac_Tumor	Testicular Yolk Sac Tumor, Papillary Pattern
C39929	Testicular_Yolk_Sac_Tumor_Myxomatous_Pattern	Testicular_Yolk_Sac_Tumor	Testicular Yolk Sac Tumor, Myxomatous Pattern
C39930	Testicular_Yolk_Sac_Tumor_Polyvesicular_Vitelline_Pattern	Testicular_Yolk_Sac_Tumor	Testicular Yolk Sac Tumor, Polyvesicular Vitelline Pattern
C39931	Testicular_Yolk_Sac_Tumor_Hepatoid_Pattern	Testicular_Yolk_Sac_Tumor	Testicular Yolk Sac Tumor, Hepatoid Pattern
C39932	Testicular_Yolk_Sac_Tumor_Enteric_Pattern	Testicular_Yolk_Sac_Tumor	Testicular Yolk Sac Tumor, Enteric Pattern
C39934	Testicular_Trophoblastic_Neoplasm	Pure_Testicular_Germ_Cell_Tumor|Testicular_Non-Seminomatous_Germ_Cell_Tumor|Trophoblastic_Neoplasm	Testicular Trophoblastic Tumor
C39935	Testicular_Monomorphic_Choriocarcinoma	Testicular_Choriocarcinoma	Testicular Monophasic Choriocarcinoma
C39936	Monodermal_Testicular_Teratoma	Testicular_Teratoma	Monodermal Testicular Teratoma
C39938	RAPGEF1_Gene	Signaling_Pathway_Gene	RAPGEF1 Gene|C3G|GRF2|RGE1|Rap Guanine Nucleotide Exchange Factor (GEF) 1 Gene	The protein encoded by this gene is a human guanine nucleotide releasing protein for Ras protein. It belongs to the adaptor-type Src homology (SH)2-containing molecules. Src homology 2 domains are globular protein modules present in a large variety of functionally distinct proteins. They mediate binding events that control the activity and localization of many proteins involved in the transmission of signals from the cell surface to the nucleus. The mRNAs of these proteins are expressed ubiquitously in human adult and fetal tissues. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined. (from LocusLink)
C39939	RASGRF2_Gene	Signaling_Pathway_Gene	RASGRF2 Gene|GRF2|RAS-GRF2|Ras Protein-Specific Guanine Nucleotide-Releasing Factor 2 Gene	This gene belongs to the family of RAS Guanine-nucleotide exchange factors (GEFs) that stimulate the conversion of the GDP-bound form into the active form in RAS GTPase cycle. (from LocusLink)
C39940	Exercise_Physiology	Physiology	Exercise Physiology	Exercise Physiology is the identification of physiological mechanisms underlying physical activity, the comprehensive delivery of treatment services concerned with the analysis, improvement, and maintenance of health and fitness, rehabilitation of heart disease and other chronic diseases and/or disabilities, and the professional guidance and counsel of athletes and others interested in athletics, sports training, and human adaptability to acute and chronic exercise. (American Society of Exercise Physiologists)
C39941	_4q31_2	Chromosome_Band	4q31.2	A chromosome band present on 4q
C39942	Testicular_Malignant_Leydig_Cell_Tumor	Malignant_Leydig_Cell_Tumor|Testicular_Leydig_Cell_Tumor	Malignant Testicular Leydig Cell Tumor
C39943	Testicular_Sertoli_Cell_Tumor_Lipid_Rich_Variant	Benign_Testicular_Sertoli_Cell_Tumor	Testicular Sertoli Cell Tumor, Lipid Rich Variant
C39944	Testicular_Large_Cell_Calcifying_Sertoli_Cell_Tumor	Benign_Testicular_Sertoli_Cell_Tumor	Testicular Large Cell Calcifying Sertoli Cell Tumor
C39945	Testicular_Sclerosing_Sertoli_Cell_Tumor	Benign_Testicular_Sertoli_Cell_Tumor	Testicular Sclerosing Sertoli Cell Tumor
C39946	Testicular_Granulosa_Cell_Tumor_Adult_Type	Testicular_Granulosa_Cell_Tumor	Adult Type Testicular Granulosa Cell Tumor
C39947	Testicular_Granulosa_Cell_Tumor_Juvenile_Type	Juvenile_Granulosa_Cell_Tumor|Testicular_Granulosa_Cell_Tumor	Juvenile Type Testicular Granulosa Cell Tumor
C39948	Testicular_Malignant_Sex_Cord-Stromal_Tumor	Malignant_Testicular_Neoplasm|Testicular_Sex_Cord-Stromal_Tumor	Malignant Testicular Sex Cord-Stromal Tumor
C39949	Testicular_Tumor_of_the_Thecoma_Fibroma_Group	Testicular_Sex_Cord-Stromal_Tumor|Tumor_of_the_Thecoma_Fibroma_Group	Testicular Tumor of the Thecoma/Fibroma Group
C39950	Tumor_of_the_Thecoma_Fibroma_Group	Sex_Cord-Stromal_Tumor	Tumor of the Thecoma/Fibroma Group
C39951	Testicular_Fibroma	Testicular_Tumor_of_the_Thecoma_Fibroma_Group	Testicular Fibroma
C39952	Testicular_Thecoma	Testicular_Tumor_of_the_Thecoma_Fibroma_Group	Testicular Thecoma
C39953	Testicular_Brenner_Tumor	Brenner_Tumor|Testicular_Neoplasm	Testicular Brenner Tumor
C39954	Brenner_Tumor	Transitional_Cell_Neoplasm	Brenner Tumor
C39955	Rete_Testis_Neoplasm	Male_Reproductive_System_Neoplasm	Rete Testis Neoplasm
C39956	Rete_Testis_Adenoma	Benign_Male_Reproductive_System_Neoplasm|Rete_Testis_Neoplasm	Rete Testis Adenoma
C39957	Adenocarcinoma_of_the_Epididymis	Adenocarcinoma|Malignant_Epididymal_Neoplasm	Epididymal Adenocarcinoma|Adenocarcinoma of the Epididymis
C39958	Epididymal_Neoplasm	Male_Reproductive_System_Neoplasm	Epididymal Neoplasm
C39959	Mixed_Squamous_Cell_Carcinoma_of_the_Penis	Squamous_Cell_Carcinoma_of_the_Penis	Mixed Squamous Cell Carcinoma of the Penis
C39961	Penile_Basal_Cell_Carcinoma	Basal_Cell_Carcinoma|Penile_Carcinoma	Penile Basal Cell Carcinoma|Basal Cell Carcinoma of the Penis
C39963	Penile_Bowenoid_Papulosis	Bowenoid_Papulosis|Penile_Neoplasm	Penile Bowenoid Papulosis
C39964	Typical_Ovarian_Thecoma	Thecoma	Typical Ovarian Thecoma
C39965	Ovarian_Signet_Ring_Stromal_Tumor	Thecoma-Fibroma_Group_Ovarian_Tumor	Ovarian Signet Ring Stromal Tumor
C39966	Ovarian_Sertoli-Stromal_Cell_Tumor	Ovarian_Sex_Cord-Stromal_Tumor	Ovarian Sertoli-Stromal Cell Tumor
C39968	Intermediate_Differentiated_Ovarian_Sertoli-Leydig_Cell_Tumor	Androblastoma	Intermediate Differentiated Ovarian Sertoli-Leydig Cell Tumor
C39970	Ovarian_Sertoli-Leydig_Cell_Tumor_with_Heterologous_Elements	Androblastoma	Ovarian Sertoli-Leydig Cell Tumor with Heterologous Elements
C39971	Ovarian_Retiform_Sertoli-Leydig_Cell_Tumor	Androblastoma	Ovarian Retiform Sertoli-Leydig Cell Tumor
C39972	Intermediate_Differentiated_Ovarian_Sertoli-Leydig_Cell_Tumor_Variant_with_Heterologous_Elements	Intermediate_Differentiated_Ovarian_Sertoli-Leydig_Cell_Tumor|Ovarian_Sertoli-Leydig_Cell_Tumor_with_Heterologous_Elements	Intermediate Differentiated Ovarian Sertoli-Leydig Cell Tumor, Variant with Heterologous Elements
C39973	Poorly_Differentiated_Ovarian_Sertoli-Leydig_Cell_Tumor_Variant_with_Heterologous_Elements	Malignant_Androblastoma|Ovarian_Sertoli-Leydig_Cell_Tumor_with_Heterologous_Elements	Poorly Differentiated Ovarian Sertoli-Leydig Cell Tumor, Variant with Heterologous Elements
C39974	Ovarian_Sertoli-Leydig_Cell_Tumor_with_Retiform_Elements	Ovarian_Sertoli-Leydig_Cell_Tumor_with_Heterologous_Elements	Ovarian Sertoli-Leydig Cell Tumor with Retiform Elements
C39976	Sertoli_Cell_Tumor	Sex_Cord-Stromal_Tumor	Sertoli Cell Tumor
C39977	Ovarian_Stromal-Leydig_Cell_Tumor	Benign_Ovarian_Sex_Cord-Stromal_Tumor|Ovarian_Sertoli-Stromal_Cell_Tumor	Ovarian Stromal-Leydig Cell Tumor
C39978	Ovarian_Sex_Cord-Stromal_Tumor_of_Mixed_or_Unclassified_Cell_Types	Ovarian_Sex_Cord-Stromal_Tumor	Ovarian Sex Cord-Stromal Tumor of Mixed or Unclassified Cell Types
C39979	Ovarian_Steroid_Cell_Tumor_Not_Otherwise_Specified	Steroid_Cell_Tumor_of_the_Ovary	Ovarian Steroid Cell Tumor, not Otherwise Specified|Ovarian Steroid Cell Tumor, NOS
C39980	Well_Differentiated_Ovarian_Steroid_Cell_Tumor	Ovarian_Steroid_Cell_Tumor_Not_Otherwise_Specified	Well Differentiated Ovarian Steroid Cell Tumor
C39981	Malignant_Ovarian_Steroid_Cell_Tumor	Malignant_Ovarian_Sex_Cord-Stromal_Tumor|Ovarian_Steroid_Cell_Tumor_Not_Otherwise_Specified	Malignant Ovarian Steroid Cell Tumor
C39983	Ovarian_Leydig_Cell_Tumor_Non-Hilar_Type	Ovarian_Leydig_Cell_Tumor	Ovarian Leydig Cell Tumor, Non-Hilar Type
C39984	Ovarian_Leydig_Cell_Tumor_Not_Otherwise_Specified	Ovarian_Leydig_Cell_Tumor	Ovarian Leydig Cell Tumor, not Otherwise Specified
C39985	Ovarian_Gonadoblastoma	Gonadoblastoma|Ovarian_Mixed_Germ_Cell-Sex_Cord-Stromal_Tumor	Ovarian Gonadoblastoma
C39986	Ovarian_Primitive_Germ_Cell_Tumor	Malignant_Ovarian_Germ_Cell_Tumor	Ovarian Primitive Germ Cell Tumor
C39987	Ovarian_Yolk_Sac_Tumor_Polyvesicular_Vitelline_Pattern	Ovarian_Yolk_Sac_Tumor	Ovarian Yolk Sac Tumor, Polyvesicular Vitelline Pattern
C39988	Ovarian_Yolk_Sac_Tumor_Glandular_Pattern	Ovarian_Yolk_Sac_Tumor	Ovarian Yolk Sac Tumor, Glandular Pattern
C39989	Ovarian_Yolk_Sac_Tumor_Hepatoid_Pattern	Ovarian_Yolk_Sac_Tumor	Ovarian Yolk Sac Tumor, Hepatoid Pattern
C39990	Polyembryoma_of_the_Ovary	Ovarian_Primitive_Germ_Cell_Tumor	Ovarian Polyembryoma|Polyembryoma of the Ovary
C39991	Non-Gestational_Ovarian_Choriocarcinoma	Ovarian_Choriocarcinoma|Ovarian_Primitive_Germ_Cell_Tumor	Non-Gestational Ovarian Choriocarcinoma
C39992	Ovarian_Biphasic_or_Triphasic_Teratoma	Ovarian_Teratoma	Ovarian Biphasic or Triphasic Teratoma
C39993	Grade_1_Immature_Ovarian_Teratoma	Immature_Ovarian_Teratoma	Grade 1 Immature Ovarian Teratoma
C39994	Grade_2_Immature_Ovarian_Teratoma	Immature_Ovarian_Teratoma	Grade 2 Immature Ovarian Teratoma
C39995	Grade_3_Immature_Ovarian_Teratoma	Immature_Ovarian_Teratoma	Grade 3 Immature Ovarian Teratoma
C39996	Ovarian_Fetiform_Teratoma	Mature_Ovarian_Teratoma	Ovarian Fetiform Teratoma
C39997	Ovarian_Dermoid_Cyst_with_Secondary_Carcinoma	Ovarian_Dermoid_Cyst_with_Secondary_Tumor	Ovarian Dermoid Cyst with Secondary Carcinoma
C39998	Ovarian_Dermoid_Cyst_with_Squamous_Cell_Carcinoma	Ovarian_Dermoid_Cyst_with_Secondary_Carcinoma	Ovarian Dermoid Cyst with Squamous Cell Carcinoma
C39999	Ovarian_Dermoid_Cyst_with_Adenocarcinoma	Ovarian_Dermoid_Cyst_with_Secondary_Carcinoma	Ovarian Dermoid Cyst with Adenocarcinoma
C40000	Ovarian_Dermoid_Cyst_with_Secondary_Melanocytic_Lesion	Ovarian_Dermoid_Cyst_with_Secondary_Tumor	Ovarian Dermoid Cyst with Secondary Melanocytic Lesion
C40001	Ovarian_Dermoid_Cyst_with_Melanoma	Ovarian_Dermoid_Cyst_with_Secondary_Melanocytic_Lesion	Ovarian Dermoid Cyst with Melanoma
C40002	Ovarian_Dermoid_Cyst_with_Melanocytic_Nevus	Ovarian_Dermoid_Cyst_with_Secondary_Melanocytic_Lesion	Ovarian Dermoid Cyst with Melanocytic Nevus
C40003	Ovarian_Dermoid_Cyst_with_Secondary_Sebaceous_Tumor	Ovarian_Dermoid_Cyst_with_Secondary_Tumor	Ovarian Dermoid Cyst with Secondary Sebaceous Tumor
C40004	Ovarian_Dermoid_Cyst_with_Sebaceous_Carcinoma	Ovarian_Dermoid_Cyst_with_Secondary_Sebaceous_Tumor	Ovarian Dermoid Cyst with Sebaceous Carcinoma
C40005	Ovarian_Dermoid_Cyst_with_Sebaceous_Adenoma	Ovarian_Dermoid_Cyst_with_Secondary_Sebaceous_Tumor	Ovarian Dermoid Cyst with Sebaceous Adenoma
C40006	Ovarian_Dermoid_Cyst_with_Secondary_Pituitary-Type_Tumor	Ovarian_Dermoid_Cyst_with_Secondary_Tumor	Ovarian Dermoid Cyst with Secondary Pituitary-Type Tumor
C40007	Ovarian_Dermoid_Cyst_with_Corticotropin_Secreting_Adenoma	Ovarian_Dermoid_Cyst_with_Secondary_Pituitary-Type_Tumor	Ovarian Dermoid Cyst with Corticotropin Secreting Adenoma
C40008	Ovarian_Dermoid_Cyst_with_Prolactin_Secreting_Adenoma	Ovarian_Dermoid_Cyst_with_Secondary_Pituitary-Type_Tumor	Ovarian Dermoid Cyst with Prolactin Secreting Adenoma
C40009	Ovarian_Dermoid_Cyst_with_Secondary_Sarcoma	Ovarian_Dermoid_Cyst_with_Secondary_Tumor	Ovarian Dermoid Cyst with Secondary Sarcoma
C40010	Ovarian_Dermoid_Cyst_with_Leiomyosarcoma	Ovarian_Dermoid_Cyst_with_Secondary_Sarcoma	Ovarian Dermoid Cyst with Leiomyosarcoma
C40011	Ovarian_Dermoid_Cyst_with_Angiosarcoma	Ovarian_Dermoid_Cyst_with_Secondary_Sarcoma	Ovarian Dermoid Cyst with Angiosarcoma
C40012	Benign_Struma_Ovarii	Struma_Ovarii	Benign Struma Ovarii
C40013	Ovarian_Insular_Carcinoid_Tumor	Ovarian_Carcinoid_Tumor	Ovarian Insular Carcinoid Tumor
C40014	Ovarian_Trabeculal_Carcinoid_Tumor	Ovarian_Carcinoid_Tumor	Ovarian Trabecular Carcinoid Tumor
C40015	Ovarian_Mucinous_Carcinoid_Tumor	Ovarian_Carcinoid_Tumor	Ovarian Mucinous Carcinoid Tumor
C40016	Rete_Ovarii_Neoplasm	Female_Reproductive_System_Neoplasm	Rete Ovarii Neoplasm
C40017	Rete_Ovarii_Adenocarcinoma	Adenocarcinoma|Malignant_Female_Reproductive_System_Neoplasm|Rete_Ovarii_Neoplasm	Rete Ovarii Adenocarcinoma
C40018	Rete_Ovarii_Adenoma	Benign_Female_Reproductive_System_Neoplasm|Rete_Ovarii_Neoplasm	Rete Ovarii Adenoma
C40019	Rete_Ovarii_Cystadenoma	Benign_Female_Reproductive_System_Neoplasm|Cystadenoma|Rete_Ovarii_Neoplasm	Rete Ovarii Cystadenoma
C40020	Rete_Ovarii_Cystadenofibroma	Benign_Female_Reproductive_System_Neoplasm|Cystadenofibroma|Rete_Ovarii_Neoplasm	Rete Ovarii Cystadenofibroma
C40021	Ovarian_Lymphoma	Lymphoma_by_Site|Malignant_Ovarian_Neoplasm	Ovarian Lymphoma|Primary Ovarian Lymphoma
C40022	Primary_Peritoneal_Carcinoma	Carcinoma|Malignant_Peritoneal_Neoplasm	Primary Peritoneal Carcinoma
C40023	Primary_Peritoneal_Serous_Adenocarcinoma	Adenocarcinoma|Primary_Peritoneal_Carcinoma	Primary Peritoneal Serous Adenocarcinoma
C40024	Primary_Borderline_Peritoneal_Epithelial_Neoplasm	Neoplasm_of_Uncertain_Malignant_Potential|Peritoneal_Neoplasm	Primary Borderline Peritoneal Epithelial Neoplasm
C40025	Malignant_Ovarian_Serous_Tumor	Malignant_Ovarian_Surface_Epithelial_Stromal_Tumor|Ovarian_Serous_Neoplasm	Malignant Ovarian Serous Tumor
C40026	Malignant_Ovarian_Surface_Epithelial_Stromal_Tumor	Malignant_Ovarian_Neoplasm|Ovarian_Epithelial_Neoplasm	Malignant Ovarian Surface Epithelial-Stromal Tumor|Malignant Ovarian Surface Epithelial-Stromal Neoplasm
C40027	Borderline_Ovarian_Serous_Tumor_with_Microinvasion	Ovarian_Serous_Neoplasm	Borderline Ovarian Serous Tumor with Microinvasion|Borderline Ovarian Serous Neoplasm with Microinvasion
C40028	Borderline_Ovarian_Serous_Adenofibroma	Adenofibroma|Borderline_Ovarian_Serous_Neoplasm	Borderline Ovarian Serous Adenofibroma
C40029	Borderline_Ovarian_Serous_Cystadenofibroma	Borderline_Ovarian_Serous_Adenofibroma|Cystadenofibroma	Borderline Ovarian Serous Cystadenofibroma
C40030	Cryotherapy	Treatment	Cryotherapy|cryotherapy	Any method that uses cold temperature to treat disease.
C40031	Ovarian_Serous_Adenofibroma	Adenofibroma|Benign_Ovarian_Serous_Neoplasm	Ovarian Serous Adenofibroma
C40032	Ovarian_Serous_Cystadenofibroma	Cystadenofibroma|Ovarian_Serous_Adenofibroma	Ovarian Serous Cystadenofibroma
C40033	Malignant_Ovarian_Mucinous_Tumor	Malignant_Ovarian_Surface_Epithelial_Stromal_Tumor|Ovarian_Mucinous_Neoplasm	Malignant Ovarian Mucinous Tumor|Malignant Ovarian Mucinous Neoplasm
C40034	Ovarian_Mucinous_Adenocarcinofibroma	Adenocarcinofibroma|Malignant_Ovarian_Mucinous_Tumor	Ovarian Mucinous Adenocarcinofibroma|Ovarian Mucinous Malignant Adenofibroma
C40035	Adenocarcinofibroma	Malignant_Mixed_Neoplasm|Mixed_Mesodermal_Mullerian_Tumor	Adenocarcinofibroma|Malignant Adenofibroma
C40036	Borderline_Ovarian_Mucinous_Tumor	Borderline_Ovarian_Epithelial_Neoplasm|Ovarian_Mucinous_Neoplasm	Borderline Ovarian Mucinous Tumor|Borderline Ovarian Mucinous Neoplasm
C40037	Borderline_Ovarian_Mucinous_Tumor_Intestinal_Type	Borderline_Ovarian_Mucinous_Tumor	Borderline Ovarian Mucinous Tumor, Intestinal Type
C40038	Borderline_Ovarian_Mucinous_Tumor_Endocervical-like	Borderline_Ovarian_Mucinous_Tumor	Borderline Ovarian Mucinous Tumor, Endocervical-like
C40039	Benign_Ovarian_Mucinous_Tumor	Benign_Ovarian_Epithelial_Neoplasm|Ovarian_Mucinous_Neoplasm	Benign Ovarian Mucinous Tumor|Benign Ovarian Mucinous Neoplasm
C40040	Ovarian_Mucinous_Adenofibroma	Benign_Ovarian_Mucinous_Tumor|Mucinous_Adenofibroma	Ovarian Mucinous Adenofibroma
C40041	Ovarian_Mucinous_Cystadenofibroma	Mucinous_Cystadenofibroma|Ovarian_Mucinous_Adenofibroma	Ovarian Mucinous Cystadenofibroma
C40042	Mucinous_Cystic_Tumor_with_Mural_Nodules	Ovarian_Mucinous_Neoplasm	Ovarian Mucinous Cystic Tumor with Mural Nodules
C40043	Ovarian_Mucinous_Cystic_Tumor_Associated_with_Pseudomyxoma_Peritonei	Ovarian_Mucinous_Neoplasm	Ovarian Mucinous Cystic Tumor Associated with Pseudomyxoma Peritonei
C40044	_8q11-q12	Chromosome_Band	8q11-q12	A chromosome band present on 8q
C40045	_15q23-q24	Chromosome_Band	15q23-q24	A chromosome band present on 15q
C40046	_8q21-q22	Chromosome_Band	8q21-q22	A chromosome band present on 8q
C40047	_10q24_3	Chromosome_Band	10q24.3	A chromosome band present on 10q
C40048	_12q13_1-q13_3	Chromosome_Band	12q13.1-q13.3	A chromosome band present on 12q
C40049	CYP2B6_Gene	Cytochrome_P450_Family_Gene	CYP2B6 Gene|CYP2B6|Cytochrome P450, Family 2, Subfamily B, Polypeptide 6 Gene	Human CYP2B6 gene (cytochrome P450 family 2, subfamily B), located at 19q13.2, encodes cytochrome P450 2B6, a monooxygenase enzyme that catalyzes the oxidation of fatty acids, drugs and xenobiotics. This gene is embedded in the CYP2A7P1 pseudogene.
C40050	Cytochrome_P450-2B6	Cytochrome-P450	Cytochrome P450 2B6|CPB6|CYP2B|CYP2B6|CYPIIB6|Cytochrome P450 CYP2B6|Cytochrome P450 Family 2 Subfamily B Polypeptide 6|IIB1|P450|P450 IIB1	Expressed in liver, lung, and heart by phenobarbital-induced human CYP2B6 Gene (Cytochrome P450 Family), 491-aa 56-kDa Cytochrome P450 2B6 is an endoplasmic reticulum membrane-bound P450 heme-thiolate monooxygenase involved in an NADPH-dependent electron transport pathway that oxidizes diverse unrelated compounds, including steroids, fatty acids, and xenobiotics such as cyclophosphamide and ifosfamide. Phosphorylation may decrease CYP2B6 activity. P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
C40051	Malignant_Ovarian_Endometrioid_Tumor	Malignant_Ovarian_Surface_Epithelial_Stromal_Tumor|Ovarian_Endometrioid_Tumor	Malignant Ovarian Endometrioid Tumor
C40052	CYP7A1_Gene	Cytochrome_P450_Family_Gene	CYP7A1 Gene|CP7A|CYP7|CYP7A1|Cytochrome P450, Family 7, Subfamily A, Polypeptide 1 Gene	Human CYP7A1 gene (cytochrome P450 family 7, subfamily A), located at 8q11-q12, encodes cytochrome P450 7A1, a monooxygenase enzyme with cholesterol 7-alpha-hydroxylase activity that catalyzes the first step in bile acid synthesis. Functional mutations in CYP7A1 that decrease or abolish the catalytic activity of the enzyme are associated with elevated levels of low density lipoprotein.
C40053	Cytochrome-P450-7A1	Cytochrome-P450	Cytochrome P450 7A1|CYP7A1|CYPVII|Cholesterol 7 Alpha-Monooxygenase|Cholesterol 7-Alpha-Hydroxylase|Cytochrome P450 Family 7 Subfamily A Polypeptide 1|Cytochrome P450 Subfamily VIIA (Cholesterol 7 Alpha-Monooxygenase) Polypeptide 1	Encoded by human CYP7A1 Gene (Cytochrome P450 Family), 504-aa 58-kDa Cytochrome P450 7A1 is an endoplasmic reticulum membrane-bound P450 heme-thiolate monooxygenase in the liver that catalyzes the first (rate-limiting) reaction in the cholesterol catabolic pathway: cholesterol conversion to bile acids, the major site of regulation of bile acid synthesis and the primary mechanism for removal of cholesterol from the body. P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
C40054	CYP8B1_Gene	Cytochrome_P450_Family_Gene	CYP8B1 Gene|CP8B|CYP12|CYP8B1|Cytochrome P450, Family 8, Subfamily B, Polypeptide 1 Gene	Human CYP8B1 gene (cytochrome P450 family 8, subfamily 2), located at 3p22-p21.3, encodes cytochrome P450 8B1, a monooxygenase enzyme with sterol 12-alpha-hydroxylase activity that is important in bile acid biosynthesis. CYP8B1 is the only gene in the cytochrome P450 superfamily that does not contain introns.
C40055	Cytochrome-P450-8B1	Cytochrome-P450	Cytochrome P450 8B1|7 Alpha-Hydroxy-4-Cholesten-3-One 12-Alpha-Hydroxylase|CYP8B1|CYPVIIIB1|Cytochrome P450 CYP8B1|Cytochrome P450 Family 8 Subfamily B Polypeptide 1|Cytochrome P450 Subfamily VIIIB (Sterol 12-Alpha-Hydroxylase) Polypeptide 1|Steroid 12-Alpha-Hydroxylase|Sterol 12 Alpha Hydroxylase	Encoded by human CYP8B1 Gene (Cytochrome P450 Family), 501-aa 58-kDa Cytochrome P450 8B1 is a liver endoplasmic reticulum membrane P450 heme-thiolate monooxygenase involved in bile acid synthesis that catalyzes conversion of 7 alpha-hydroxy-4-cholesten-3-one into 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one. The balance between these steroids determines the relative amount of cholic and chenodeoxycholic acids secreted in the bile that affect cholesterol solubility. CYP8B1 has broad substrate specificity including 7-alpha-hydroxylated C27 steroids. P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
C40056	CYP11A1_Gene	Cytochrome_P450_Family_Gene	CYP11A1 Gene|CYP11A|CYP11A1|Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 Gene|P450SCC	Human CYP11A1 gene (cytochrome P450 family 11, subfamily A), located at 15q23-q24, encodes the cytochrome P450 11A1 protein, a monooxygenase enzyme that plays a role in steroid synthesis. Alleles of this gene that exhibit functional mutations typically result in 17-alpha-hydroxylase/17,20-lyase deficiency. CYP11A1 defects cause congenital adrenal insufficiency and congenital lipoid adrenal hyperplasia.
C40057	Cytochrome-P450C11A1	Cytochrome-P450	Cytochrome P450C11A1|CYP11A1|CYPXIA1|Cholesterol 20-22 Desmolase|Cholesterol Desmolase|Cholesterol Monooxygenase (Side-Chain Cleaving)|Cholesterol Side-Chain Cleavage Enzyme|Cytochrome P-450scc|Cytochrome P450 Subfamily XIA|Cytochrome P450 Subfamily XIA (Cholesterol Side Chain Cleavage)|Mitochondrial Cytochrome P450 11A1|P450(scc)|Steroid 20-22-Lyase	Encoded by human CYP11A1 Gene (Cytochrome P450 Family), 521-aa 60-kDa (precursor) Cytochrome P450C11A1 is a mitochondrial inner membrane P450 heme-thiolate monooxygenase that catalyzes a side-chain cleavage reaction conversion of cholesterol to pregnenolone, the first (rate-limiting) step in the synthesis of steroid hormones. CYP11A1 defects cause congenital adrenal insufficiency (CAI) and congenital lipoid adrenal hyperplasia (CLAH). P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
C40058	CYP11B1_Gene	Cytochrome_P450_Family_Gene	CYP11B1 Gene|CPN1|CYP11B|CYP11B1|Cytochrome P450, Family 11, Subfamily B, Polypeptide 1 Gene|FHI|P450C11|S11BH	Human CYP11B1 gene (cytochrome P450 family 11, subfamily B), located at 8q21, encodes the cytochrome P450 11B1 protein, a monooxygenase enzyme with steroid 11-beta-hydroxylase activity. Functional mutations in this gene can result in 11-beta-hydroxylase deficiency which, in turn, causes congenital adrenal hyperplasia. CYP11B1/CYP11B2 gene fusion causes glucocorticoid-remediable aldosteronism.
C40059	Cytochrome-P450-CYP11B1	Cytochrome-P450	Cytochrome P450 CYP11B1|CYP11B1|CYPXIB1|Cytochrome P450 CYP11B2|Cytochrome P450 Subfamily XIB (Steroid 11-Beta-Hydroxylase) Polypeptide 1|Cytochrome p450 XIB1|Mitochondrial Cytochrome P450 11B1|P450C11|Steroid 11 Beta Monooxygenase|Steroid 11-Beta-Hydroxylase	Encoded by human CYP11B1 Gene (Cytochrome P450 Family), 503-aa 58-kDa (precursor) Cytochrome P450 CYP11B1 is a mitochondrial inner membrane P450 heme-thiolate monooxygenase expressed in adrenal cortex with steroid 11-beta-hydroxylase activity and involved in conversion of progesterone to cortisol. The 18 or 19-hydroxylation of steroids and aromatization of androstendione to estrone have also been ascribed to CYP11B1. CYP11B1 defects cause adrenal hyperplasia type IV (AH-IV). CYP11B1/CYP11B2 gene fusion causes glucocorticoid-remediable aldosteronism (GRA). P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
C40060	Ovarian_Endometrioid_Adenocarcinofibroma	Adenocarcinofibroma|Malignant_Ovarian_Endometrioid_Tumor	Ovarian Endometrioid Adenocarcinofibroma|Ovarian Endometrioid Malignant Adenofibroma
C40061	Ovarian_Endometrioid_Adenocarcinoma_with_Squamous_Differentiation	Ovarian_Endometrioid_Adenocarcinoma	Ovarian Endometrioid Adenocarcinoma with Squamous Differentiation|Ovarian Adenoacanthoma|Ovarian Adenosquamous Carcinoma
C40062	CYP11B2_Gene	Cytochrome_P450_Family_Gene	CYP11B2 Gene|ALDOS|CPN2|CYP11B|CYP11B2|CYP11BL|Cytochrome P450, Family 11, Subfamily B, Polypeptide 2 Gene|P-450C18|P450Aldo	Human CYP11B2 gene (cytochrome P450 family 11, subfamily B), located at 8q21-q22, encodes cytochrome P450 11B2, a monooxygenase with steroid 11-beta-hydroxylase activity. Functional mutations in the CYP11B2 gene are typically associated with congenital hypoaldosteronism, a disorder that is due to corticosterone methyloxidase type II deficiency. CYP11B1/CYP11B2 gene fusion causes glucocorticoid-remediable aldosteronism.
C40063	Low_Grade_Ovarian_Endometrioid_Stromal_Sarcoma	Low_Grade_Endometrial_Stromal_Sarcoma|Ovarian_Endometrioid_Stromal_Sarcoma	Ovarian Low Grade Endometrioid Stromal Sarcoma
C40064	Cytochrome-P450-11B2	Cytochrome-P450	Cytochrome P450 11B2|ALDOS|Aldosterone Synthase|Aldosterone-Synthesizing Enzyme|CYP11B2|CYPXIB2|Cytochrome P450 Subfamily XIB (Steroid 11-Beta-Hydroxylase) Polypeptide 2|Cytochrome P450 Subfamily XIB Polypeptide 2|Mitochondrial Cytochrome P450 11B2|P-450Aldo|P-450C18|Steroid 11-Beta-Monooxygenase|Steroid 11-Beta/18-Hydroxylase|Steroid 18-Hydroxylase	Encoded by human CYP11B2 Gene (Cytochrome P450 Family), 503-aa 58-kDa (precursor) Cytochrome P450 11B2 is a mitochondrial inner membrane P450 heme-thiolate monooxygenase with steroid 18-hydroxylase activity involved in preferential conversion of 11-deoxycorticosterone to aldosterone and 18-oxocortisol via corticosterone and 18-hydroxycorticosterone. CYP11B2 also has steroid 11 beta-hydroxylase activity. CYP11B2 defects cause corticosterone methyloxidase type I deficiency (CMO-I deficiency) and corticosterone methyloxidase type II deficiency (CMO-II deficiency). CYP11B2/CYP11B1 gene fusion causes glucocorticoid-remediable aldosteronism (GRA). P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
C40065	Ovarian_Endometrioid_Stromal_Sarcoma	Endometrial_Stromal_Sarcoma|Ovarian_Sarcoma	Ovarian Endometrioid Stromal Sarcoma
C40066	Undifferentiated_Ovarian_Sarcoma	Ovarian_Endometrioid_Stromal_Sarcoma	Undifferentiated Ovarian Sarcoma|High Grade Ovarian Endometrioid Stromal Sarcoma
C40067	CYP17A1_Gene	Cytochrome_P450_Family_Gene	CYP17A1 Gene|CPT7|CYP17|CYP17A1|Cytochrome P450, Family 17, Subfamily A, Polypeptide 1 Gene|P450C17|S17AH	Human CYP17A1 gene (cytochrome P450 family 17, subfamily A), located at 10q24.3, encodes cytochrome P450 17A1, a monooxygenase enzyme with 17-alpha-hydroxylase activity that catalyzes the oxidation of steroids. Functional mutations in the CYP17A1 gene typically result in 17-alpha-hydroxylase deficiency which, in turn, causes adrenal hyperplasia.
C40068	Cytochrome-P450-XVIIA1	Cytochrome-P450	Cytochrome P450 XVIIA1|CYP17A1|CYPXVII|Cytochrome P450 Family 17|Cytochrome P450 Subfamily XVII (Steroid 17-Alpha-Hydroxylase)|P450-C17|Steroid 17-Alpha-Hydroxylase|Steroid 17-Alpha-Hydroxylase/17,20 Lyase|Steroid 17-Alpha-Monooxygenase	Encoded by human CYP17A1 Gene (Cytochrome P450 Family), 508-aa 57-kDa Cytochrome P450 XVIIA1 is a cAMP-regulated endoplasmic reticulum P450 heme-thiolate monooxygenase with 17alpha-hydroxylase and 17,20-lyase activity and a key enzyme in the steroidogenic pathway that produces progestins, mineralocorticoids, glucocorticoids, androgens, and estrogens. Involved in fetal and adult sexual development, CYP17A1 converts pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. CYP17A1 mutations are associated with steroid-17 alpha-hydroxylase deficiency, 17-alpha-hydroxylase/17,20-lyase deficiency, pseudohermaphroditism, and adrenal hyperplasia type V (AH-V). P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
C40069	Borderline_Ovarian_Endometrioid_Adenofibroma	Adenofibroma|Borderline_Ovarian_Endometrioid_Tumor	Borderline Ovarian Endometrioid Adenofibroma
C40070	CYP21A2_Gene	Cytochrome_P450_Family_Gene	CYP21A2 Gene|CA21H|CAH1|CPS1|CYP1ALPHA|CYP21|CYP21A2|CYP21B|CYP27B|CYP27B1|Cytochrome P450, Family 21, Subfamily A, Polypeptide 2 Gene|P450c21B	Human CYP21A2 gene (cytochrome P450 family 21, subfamily A), located at 6p21.3, encodes cytochrome P450 21A2, a monooxygenase enzyme that specifically catalyzes the 21-hydoxylation of steroids. Gene conversion events involving CYP21A2 and a nearby pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. Defects in CYP231A2 cause congenital adrenal hyperplasia.
C40071	Cytochrome-P450-XXIB	Cytochrome-P450	Cytochrome P450 XXIB|CYP21|CYP21A2|CYP21B|Cytochrome P450 Family 21 Subfamily A Polypeptide 2|Cytochrome P450 Subfamily XXIA (Steroid 21-Hydroxylase) Polypeptide 2|Cytosteroid 21-Monooxygenase|P450-C21B|Steroid 21-Hydroxylase	Encoded by human CYP21A2 Gene (Cytochrome P450 Family), 494-aa 56-kDa Cytochrome P450 XXIB is a membrane-bound endoplasmic reticulum P450 heme-thiolate monooxygenase that hydroxylates steroids at the 21 position and is required for synthesis of steroid hormones including cortisol and aldosterone. The leucine-rich hydrophobic N-terminal region may anchor the protein. CYP21A2 defects cause congenital adrenal hyperplasia (CAH). Gene conversion events involving CYP21A2 and a nearby pseudogene are thought to account for many cases of steroid 21-hydroxylase deficiency. P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
C40072	Benign_Ovarian_Endometrioid_Tumor	Benign_Ovarian_Epithelial_Neoplasm|Ovarian_Endometrioid_Tumor	Benign Ovarian Endometrioid Tumor
C40073	CYP27B1_Gene	Cytochrome_P450_Family_Gene	CYP27B1 Gene|CP2B|CYP1|CYP27B|CYP27B1|Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 Gene|P450c1|PDDR|VDD1|VDDR|VDDRI|VDR	Human CYP27B1 gene (cytochrome P450 family 27, subfamily B), located at 12q13.1-q13.3, encodes cytochrome P450 27B1 protein, a monooxygenase enzyme with 25-hydroxyvitamin D-1 alpha hydroxylase activity. Many CYP27B1 alleles encode proteins that are either inactive or have reduced catalytic activity which, in turn, results in pseudovitamin D deficiency rickets.
C40074	Cytochrome-P450-CYP27B	Cytochrome-P450	Cytochrome P450 CYP27B|25 Hydroxy Vitamin D3 1 Alpha Hydroxylase|25-Hydroxyvitamin D(3) 1-Alpha-Hydroxylase|25-Hydroxyvitamin D-1-Alpha-Hydroxylase|25-Hydroxyvitamin D3 1-Alpha-Hydroxylase|25-OHD-1 Alpha-Hydroxylase|CYP27B1|Calcidiol 1 Monooxygenase|Cytochrome P450 Family 27 Subfamily B Polypeptide 1|Cytochrome P450 Subfamily XXVIIB (25-Hydroxyvitamin D-1-Alpha-Hydroxylase) Polypeptide 1|Mitochondrial 25-Hydroxyvitamin D-1 Alpha Hydroxylase|P450C1 Alpha|P450VD1-Alpha|VD3 1A Hydroxylase	Encoded by human CYP27B1 Gene (Cytochrome P450 Family), 508-aa 57-kDa (precursor) Cytochrome P450 CYP27B is a kidney inner mitochondrial membrane P450 heme-thiolate monooxygenase that hydroxylates 25-hydroxyvitamin D3 at the 1alpha position to synthesize (second, last step) 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3 that binds to vitamin D receptor and regulates calcium metabolism. In regulating the level of biologically active vitamin D and calcium homeostasis, CYP27B1 plays an important role in normal bone growth and tissue differentiation. CYP27B1 defects cause vitamin D-dependent rickets type 1 (VDDR-1). P450 enzymes catalyze reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. (NCI)
C40075	Ovarian_Endometrioid_Cystadenoma	Benign_Ovarian_Endometrioid_Tumor|Ovarian_Cystadenoma	Ovarian Endometrioid Cystadenoma
C40076	Ovarian_Clear_Cell_Tumor	Ovarian_Epithelial_Neoplasm	Ovarian Clear Cell Tumor|Ovarian Clear Cell Neoplasm	A benign, borderline or malignant glandular epithelial neoplasm characterized by a predominance of clear and hobnail cells.
C40077	Malignant_Ovarian_Clear_Cell_Tumor	Malignant_Ovarian_Surface_Epithelial_Stromal_Tumor|Ovarian_Clear_Cell_Tumor	Malignant Ovarian Clear Cell Tumor|Malignant Ovarian Clear Cell Neoplasm	A malignant glandular epithelial neoplasm characterized by a predominance of glycogen-rich clear and hobnail cells.
C40078	Ovarian_Clear_Cell_Adenocarcinoma	Clear_Cell_Adenocarcinoma|Malignant_Ovarian_Clear_Cell_Tumor|Ovarian_Adenocarcinoma	Ovarian Clear Cell Adenocarcinoma	A malignant glandular epithelial tumor characterized by the presence of clear and hobnail cells. The tumor is highly associated with ovarian endometriosis, pelvic endometriosis and paraendocrine hypercalcemia.
C40079	Ovarian_Clear_Cell_Adenocarcinofibroma	Adenocarcinofibroma|Malignant_Ovarian_Clear_Cell_Tumor	Ovarian Clear Cell Adenocarcinofibroma|Ovarian Clear Cell Malignant Adenofibroma	A malignant tumor composed of glandular epithelium within a fibrous stroma.  It is characterized by the presence of clear cells.
C40080	Borderline_Ovarian_Clear_Cell_Tumor	Borderline_Ovarian_Epithelial_Neoplasm|Ovarian_Clear_Cell_Tumor	Borderline Ovarian Clear Cell Tumor|Borderline Ovarian Clear Cell Neoplasm	An epithelial neoplasm with low malignant potential affecting the ovary.  It is characterized by the presence of clear or hobnail cells.  In some cases, the cells may display nuclear atypia and prominent nucleoli.  When such cells are present, they remain confined to the glands.  There is no evidence of stromal invasion.
C40081	Borderline_Ovarian_Clear_Cell_Adenofibroma	Borderline_Ovarian_Clear_Cell_Tumor|Clear_Cell_Adenofibroma	Borderline Ovarian Clear Cell Adenofibroma	An epithelial neoplasm with low malignant potential affecting the ovary.  It is characterized by the presence of atypical glands and/or cystic spaces lined with clear or hobnail cells.
C40082	Borderline_Ovarian_Clear_Cell_Adenofibroma_with_Intraepithelial_Carcinoma	Borderline_Ovarian_Clear_Cell_Adenofibroma	Borderline Ovarian Clear Cell Adenofibroma with Intraepithelial Carcinoma	An epithelial neoplasm with low malignant potential affecting the ovary.  It is characterized by the presence of atypical glands and/or cystic spaces lined with clear or hobnail cells.  The cells display nuclear atypia and prominent nucleoli.  There is no invasion of the ovarian stroma by the atypical cells.
C40083	Borderline_Ovarian_Clear_Cell_Cystadenofibroma	Borderline_Ovarian_Clear_Cell_Adenofibroma|Clear_Cell_Cystadenofibroma	Borderline Ovarian Clear Cell Cystadenofibroma	An epithelial neoplasm with low malignant potential affecting the ovary.  It is characterized by the presence of prominent cystic spaces lined with clear or hobnail cells.
C40084	Benign_Ovarian_Clear_Cell_Tumor	Benign_Ovarian_Epithelial_Neoplasm|Ovarian_Clear_Cell_Tumor	Benign Ovarian Clear Cell Tumor|Benign Ovarian Clear Cell Neoplasm	A benign neoplasm of glandular epithelium affecting the ovary.  It is characterized by a predominance of clear and hobnail cells.
C40085	Ovarian_Clear_Cell_Adenofibroma	Benign_Ovarian_Clear_Cell_Tumor|Clear_Cell_Adenofibroma	Ovarian Clear Cell Adenofibroma	An uncommon benign neoplasm of glandular epithelium characterized by the presence of clear or hobnail cells within a dense fibrous stroma.
C40086	Ovarian_Clear_Cell_Cystadenofibroma	Clear_Cell_Cystadenofibroma|Ovarian_Clear_Cell_Adenofibroma	Ovarian Clear Cell Cystadenofibroma	A benign neoplasm of glandular epithelium characterized by the presence of clear or hobnail cells within a dense fibrous stroma and cystic structures.
C40087	Benign_Ovarian_Transitional_Cell_Tumor	Benign_Ovarian_Epithelial_Neoplasm|Ovarian_Transitional_Cell_Neoplasm	Benign Ovarian Transitional Cell Tumor|Benign Ovarian Transitional Cell Neoplasm
C40088	Borderline_Ovarian_Transitional_Cell_Tumor	Borderline_Ovarian_Epithelial_Neoplasm|Ovarian_Transitional_Cell_Neoplasm	Borderline Ovarian Transitional Cell Tumor|Borderline Ovarian Transitional Cell Neoplasm
C40089	Malignant_Ovarian_Transitional_Cell_Tumor	Malignant_Ovarian_Surface_Epithelial_Stromal_Tumor|Ovarian_Transitional_Cell_Neoplasm	Malignant Ovarian Transitional Cell Tumor|Malignant Ovarian Transitional Cell Neoplasm
C40090	Malignant_Ovarian_Mixed_Epithelial_Tumor	Malignant_Ovarian_Surface_Epithelial_Stromal_Tumor|Ovarian_Mixed_Epithelial_Neoplasm	Malignant Ovarian Mixed Epithelial Tumor|Malignant Ovarian Mixed Epithelial Neoplasm
C40091	Ovarian_Adenocarcinoma_Not_Otherwise_Specified	Ovarian_Adenocarcinoma	Ovarian Adenocarcinoma not Otherwise Specified|Ovarian Adenocarcinoma NOS
C40092	Ovarian_Squamous_Cell_Tumor	Ovarian_Epithelial_Neoplasm|Squamous_Cell_Neoplasm	Ovarian Squamous Cell Tumor|Ovarian Squamous Cell Neoplasm
C40093	Ovarian_Squamous_Cell_Carcinoma	Ovarian_Carcinoma|Ovarian_Squamous_Cell_Tumor|Squamous_Cell_Carcinoma	Ovarian Squamous Cell Carcinoma
C40095	Serotonin_2A_Receptor	G_Protein-Coupled_Receptor	Serotonin 2A Receptor|5-HT-2|5-HT-2A|5-Hydroxytryptamine 2A Receptor|5-Hydroxytryptamine Receptor 2A|HTR2A|Serotonin 5-HT-2A Receptor|Serotonin Receptor 2A	Encoded by human HTR2A Gene (GPCR1/5HT2 Family), 471-aa 53-kDa Serotonin 5-HT-2A Receptor is a conserved integral membrane 5-HT/serotonin receptor protein involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production by association with G proteins that activate a PI-calcium second messenger system. 5-HT is a biogenic hormone that affects specific receptors as a neurotransmitter, hormone, or mitogen. At least 6 types of 5-HT receptors have been identified: 5-HT-1A, -1B, -1C, -1D, -2, and -3. (NCI)
C40096	Beta-1_Adrenergic_Receptor	Beta_Adrenergic_Receptor	Beta-1 Adrenergic Receptor|ADRB1|Beta 1 Receptor|Beta-1 Adrenoceptor|Beta-1 Adrenoreceptor	Encoded by human ADRB1 Gene (GPCR1 Family), 477-aa 51-kDa conserved Beta-1-Adrenergic Receptor is an integral membrane protein receptor for catecholamine epinephrine and norepinephrine neurotransmitters that activates adenylate cyclase through G protein action. ADRB1 phosphorylation by beta-adrenergic receptor kinase mediates receptor desensitization. Agonist and antagonist drugs selective for beta-1 receptors have important applications in clinical medicine. (NCI)
C40097	Cholesterol_Ester_Transfer_Protein	Transport_Protein	Cholesteryl Ester Transfer Protein|CETP|Lipid Transfer Protein I|Plasma Cholesteryl Ester Transfer Protein	Expressed in liver by human CETP Gene (BPI/LBP Family), 493-aa 55-kDa (precursor) secreted plasma Cholesterol Ester Transfer Protein is involved in the transfer of insoluble cholesteryl esters among lipoproteins in the reverse transport of cholesterol, a vital step in normal cholesterol metabolism and homeostasis. CETP may affect susceptibility to atherosclerosis and CETP defects cause CETP deficiency. (NCI)
C40098	Taxon	Conceptual_Entities	Taxon|Biological Taxon|Taxonomy	Ranked categories for the classification of organisms according to their suspected evolutionary relationships.
C40099	Fallopian_Tube_Serous_Adenocarcinoma	Fallopian_Tube_Adenocarcinoma|Fallopian_Tube_Serous_Neoplasm|Serous_Adenocarcinoma	Fallopian Tube Serous Adenocarcinoma
C40101	Serous_Adenocarcinoma	Serous_Neoplasm	Serous Adenocarcinoma
C40102	Fallopian_Tube_Serous_Neoplasm	Fallopian_Tube_Neoplasm|Serous_Neoplasm	Fallopian Tube Serous Neoplasm|Fallopian Tube Serous Tumor
C40103	Fallopian_Tube_Mucinous_Adenocarcinoma	Fallopian_Tube_Adenocarcinoma|Fallopian_Tube_Mucinous_Neoplasm|Mucinous_Adenocarcinoma	Fallopian Tube Mucinous Adenocarcinoma
C40104	Fallopian_Tube_Transitional_Cell_Carcinoma	Fallopian_Tube_Carcinoma|Transitional_Cell_Carcinoma	Fallopian Tube Transitional Cell Carcinoma
C40105	Stage_0_Fallopian_Tube_Cancer	Fallopian_Tube_Carcinoma|Grade_III_Glandular_Intraepithelial_Neoplasia	Stage 0 Fallopian Tube Cancer|Fallopian Tube Carcinoma in Situ|Tubal Intraepithelial Carcinoma
C40106	Borderline_Fallopian_Tube_Neoplasm	Fallopian_Tube_Neoplasm|Neoplasm_of_Uncertain_Malignant_Potential	Borderline Fallopian Tube Neoplasm|Borderline Fallopian Tube Tumor|Fallopian Tube Neoplasm of Low Malignant Potential
C40107	Borderline_Fallopian_Tube_Serous_Neoplasm	Borderline_Fallopian_Tube_Neoplasm|Fallopian_Tube_Serous_Neoplasm	Borderline Fallopian Tube Serous Neoplasm|Borderline Fallopian Tube Serous Tumor
C40108	Borderline_Fallopian_Tube_Mucinous_Neoplasm	Borderline_Fallopian_Tube_Neoplasm|Fallopian_Tube_Mucinous_Neoplasm	Borderline Fallopian Tube Mucinous Neoplasm|Borderline Fallopian Tube Mucinous Tumor
C40109	Fallopian_Tube_Mucinous_Neoplasm	Fallopian_Tube_Neoplasm|Mucinous_Neoplasm	Fallopian Tube Mucinous Neoplasm|Fallopian Tube Mucinous Tumor
C40110	Borderline_Fallopian_Tube_Endometrioid_Neoplasm	Borderline_Fallopian_Tube_Neoplasm|Fallopian_Tube_Endometrioid_Tumor	Borderline Fallopian Tube Endometrioid Tumor|Borderline Fallopian Tube Endometrioid Neoplasm
C40111	Fallopian_Tube_Endometrioid_Tumor	Endometrioid_Tumor|Fallopian_Tube_Neoplasm	Fallopian Tube Endometrioid Tumor|Fallopian Tube Endometrioid Neoplasm
C40112	Fallopian_Tube_Papilloma	Benign_Fallopian_Tube_Neoplasm|Papilloma	Fallopian Tube Papilloma|Fallopian Tube Serous Papilloma
C40113	Fallopian_Tube_Adenofibroma	Adenofibroma|Benign_Fallopian_Tube_Neoplasm|Fallopian_Tube_Endometrioid_Tumor	Fallopian Tube Adenofibroma
C40114	Fallopian_Tube_Cystadenofibroma	Cystadenofibroma|Fallopian_Tube_Adenofibroma	Fallopian Tube Cystadenofibroma
C40115	Fallopian_Tube_Endometrioid_Polyp	Fallopian_Tube_Neoplasm|Neoplastic_Polyp	Fallopian Tube Endometrioid Polyp|Fallopian Tube Endometrioid Adenomatous Polyp
C40116	Fallopian_Tube_Metaplastic_Papillary_Tumor	Benign_Fallopian_Tube_Neoplasm	Fallopian Tube Metaplastic Papillary Tumor
C40117	Tubal_Epithelial_Hyperplasia	Hyperplasia	Tubal Epithelial Hyperplasia
C40118	Chronic_Salpingitis	Salpingitis	Chronic Salpingitis
C40119	Salpingitis_Isthmica_Nodosa	Salpingitis	Salpingitis Isthmica Nodosa
C40120	Acute_Salpingitis	Salpingitis	Acute Salpingitis
C40121	Endosalpingiosis	Peritoneal_Disorder	Endosalpingiosis
C40122	Pelvic_Pain	Pain	Pelvic Pain
C40123	Tubal_Diverticulosis	Diverticulosis	Tubal Diverticulosis
C40124	Fallopian_Tube_Malignant_Mixed_Mesodermal_Mullerian_Tumor	Fallopian_Tube_Endometrioid_Tumor|Malignant_Fallopian_Tube_Neoplasm|Malignant_Mixed_Mesodermal_Mullerian_Tumor	Fallopian Tube Carcinosarcoma|Fallopian Tube Malignant Mixed Mesodermal (Mullerian) Tumor
C40125	Fallopian_Tube_Mullerian_Adenosarcoma	Fallopian_Tube_Endometrioid_Tumor|Malignant_Fallopian_Tube_Neoplasm|Mullerian_Adenosarcoma	Fallopian Tube Adenosarcoma|Fallopian Tube Mullerian Adenosarcoma
C40126	Fallopian_Tube_Soft_Tissue_Neoplasm	Fallopian_Tube_Neoplasm|Soft_Tissue_Neoplasm	Fallopian Tube Soft Tissue Neoplasm
C40127	Fallopian_Tube_Leiomyoma	Benign_Fallopian_Tube_Neoplasm|Fallopian_Tube_Soft_Tissue_Neoplasm|Leiomyoma	Fallopian Tube Leiomyoma
C40128	Fallopian_Tube_Leiomyosarcoma	Fallopian_Tube_Soft_Tissue_Neoplasm|Leiomyosarcoma|Malignant_Fallopian_Tube_Neoplasm	Fallopian Tube Leiomyosarcoma
C40129	Fallopian_Tube_Adenomatoid_Tumor	Adenomatoid_Tumor|Benign_Fallopian_Tube_Neoplasm	Fallopian Tube Adenomatoid Tumor
C40130	Fallopian_Tube_Germ_Cell_Tumor	Fallopian_Tube_Neoplasm|Germ_Cell_Neoplasm|Reproductive_Endocrine_Neoplasm	Fallopian Tube Germ Cell Tumor|Fallopian Tube Germ Cell Neoplasm
C40131	Fallopian_Tube_Teratoma	Fallopian_Tube_Germ_Cell_Tumor|Teratoma	Fallopian Tube Teratoma
C40133	Uterine_Ligament_Neoplasm	Female_Reproductive_System_Neoplasm	Uterine Ligament Neoplasm|Neoplasm of the Uterine Ligament|Tumor of the Uterine Ligament|Uterine Ligament Tumor
C40134	BCHE_Gene	Esterase_Gene	BCHE Gene|BCHE|Butyrylcholinesterase Gene|CHE1|E1	Human butyrylcholinesterase (BCHE) gene (type-B carboxylesterase/lipase family), located at 3q26.1-q26.2, encodes butyrylcholinesterase protein. Allelic variants of BCHE are responsible for hypocholinesterasemia, resulting in suxamethonium sensitivity.
C40135	Uterine_Ligament_Adenocarcinoma	Malignant_Female_Reproductive_System_Neoplasm|Uterine_Ligament_Neoplasm	Uterine Ligament Adenocarcinoma
C40136	Uterine_Ligament_Serous_Adenocarcinoma	Serous_Adenocarcinoma|Uterine_Ligament_Adenocarcinoma	Uterine Ligament Serous Adenocarcinoma
C40137	Uterine_Ligament_Mucinous_Adenocarcinoma	Mucinous_Adenocarcinoma|Uterine_Ligament_Adenocarcinoma	Uterine Ligament Mucinous Adenocarcinoma
C40138	Uterine_Ligament_Endometrioid_Adenocarcinoma	Endometrioid_Carcinoma|Uterine_Ligament_Adenocarcinoma	Uterine Ligament Endometrioid Adenocarcinoma
C40139	Uterine_Ligament_Clear_Cell_Adenocarcinoma	Clear_Cell_Adenocarcinoma|Uterine_Ligament_Adenocarcinoma	Uterine Ligament Clear Cell Adenocarcinoma	A clear cell adenocarcinoma of the uterine ligament composed mainly of clear or hobnob cells. The clear cells are large, bizarre, and multinucleated.
C40140	Borderline_Uterine_Ligament_Neoplasm	Neoplasm_of_Uncertain_Malignant_Potential|Uterine_Ligament_Neoplasm	Borderline Uterine Ligament Neoplasm|Uterine Ligament Neoplasm of Low Malignant Potential
C40141	Wolffian_Adnexal_Tumor	Uterine_Ligament_Neoplasm	Wolffian Adnexal Tumor|Wolffian Adnexal Neoplasm
C40142	Uterine_Ligament_Papillary_Cystadenoma	Benign_Female_Reproductive_System_Neoplasm|Cystadenoma|Uterine_Ligament_Neoplasm	Uterine Ligament Papillary Cystadenoma
C40144	Uterine_Corpus_Mucinous_Adenocarcinoma	Mucinous_Adenocarcinoma|Type_I_Endometrial_Adenocarcinoma	Endometrial Mucinous Adenocarcinoma|Uterine Corpus Mucinous Adenocarcinoma
C40145	Type_I_Endometrial_Adenocarcinoma	Endometrial_Adenocarcinoma	Type I Endometrial Adenocarcinoma
C40146	Grade_1_Endometrial_Endometrioid_Adenocarcinoma	Uterine_Corpus_Endometrioid_Adenocarcinoma	Grade 1 Endometrial Endometrioid Adenocarcinoma
C40147	Grade_2_Endometrial_Endometrioid_Adenocarcinoma	Uterine_Corpus_Endometrioid_Adenocarcinoma	Grade 2 Endometrial Endometrioid Adenocarcinoma
C40148	Grade_3_Endometrial_Endometrioid_Adenocarcinoma	Uterine_Corpus_Endometrioid_Adenocarcinoma	Grade 3 Endometrial Endometrioid Adenocarcinoma
C40149	Grade_1_Endometrial_Mucinous_Adenocarcinoma	Uterine_Corpus_Mucinous_Adenocarcinoma	Grade 1 Endometrial Mucinous Adenocarcinoma
C40150	Grade_2_Endometrial_Mucinous_Adenocarcinoma	Uterine_Corpus_Mucinous_Adenocarcinoma	Grade 2 Endometrial Mucinous Adenocarcinoma
C40151	Grade_3_Endometrial_Mucinous_Adenocarcinoma	Uterine_Corpus_Mucinous_Adenocarcinoma	Grade 3 Endometrial Mucinous Adenocarcinoma
C40152	Endometrial_Serous_Intraepithelial_Carcinoma	Type_II_Endometrial_Adenocarcinoma	Serous Endometrial Intraepithelial Carcinoma|EIC|Endometrial Intraepithelial Carcinoma|Endometrial Serous Carcinoma in Situ|Endometrial Serous Intraepithelial Carcinoma|Endometrial Surface Serous Carcinoma
C40153	Endometrial_Mixed_Adenocarcinoma	Endometrial_Adenocarcinoma	Endometrial Mixed Adenocarcinoma
C40154	Endometrial_Transitional_Cell_Carcinoma	Endometrial_Carcinoma|Transitional_Cell_Carcinoma	Endometrial Transitional Cell Carcinoma
C40155	Endometrial_Small_Cell_Carcinoma	Endometrial_Carcinoma|Small_Cell_Carcinoma	Endometrial Small Cell Carcinoma
C40156	Endometrial_Undifferentiated_Carcinoma	Endometrial_Carcinoma|Undifferentiated_Carcinoma	Endometrial Undifferentiated Carcinoma|Undifferentiated Endometrial Carcinoma
C40157	Endometrial_Hyperplasia_without_Atypia	Endometrial_Hyperplasia	Endometrial Hyperplasia without Atypia|Typical Endometrial Hyperplasia
C40158	Endometrial_Cyst	Cyst	Endometrial Cyst
C40159	Tamoxifen-Related_Endometrial_Disorder	Endometrial_Disorder	Tamoxifen-Related Endometrial Disorder|Tamoxifen-Related Endometrial Lesion
C40160	t_7_17_p15_q21	Chromosomal_Translocation	t(7;17)(p15;q21)
C40161	JAZF1-JJAZ1_Fusion_Protein_Expression	Fusion_Protein_Expression	JAZF1-JJAZ1 Fusion Protein Expression
C40162	Uterine_Corpus_Leiomyoma_Mitotically_Active_Variant	Uterine_Corpus_Leiomyoma	Uterine Corpus Leiomyoma, Mitotically Active Variant
C40163	Uterine_Corpus_Cellular_Leiomyoma	Cellular_Leiomyoma|Uterine_Corpus_Leiomyoma	Uterine Corpus Cellular Leiomyoma
C40164	Uterine_Corpus_Epithelioid_Leiomyoma	Uterine_Corpus_Leiomyoma	Uterine Corpus Epithelioid Leiomyoma
C40165	Uterine_Corpus_Hemorrhagic_Cellular_Leiomyoma	Uterine_Corpus_Cellular_Leiomyoma	Uterine Corpus Hemorrhagic Cellular Leiomyoma|Uterine Corpus Apoplectic Leiomyoma
C40166	Uterine_Corpus_Myxoid_Leiomyoma	Uterine_Corpus_Leiomyoma	Uterine Corpus Myxoid Leiomyoma
C40167	Uterine_Corpus_Leiomyoma_Atypical_Variant	Bizarre_Leiomyoma|Uterine_Corpus_Leiomyoma	Uterine Corpus Leiomyoma, Atypical Variant|Uterine Corpus Bizarre Leiomyoma|Uterine Corpus Symplastic Leiomyoma
C40168	Uterine_Corpus_Lipoleiomyoma	Uterine_Corpus_Leiomyoma	Uterine Corpus Lipoleiomyoma
C40169	Uterine_Corpus_Diffuse_Leiomyomatosis	Uterine_Corpus_Leiomyomatosis	Uterine Corpus Diffuse Leiomyomatosis
C40170	Uterine_Corpus_Leiomyomatosis	Leiomyomatosis|Uterine_Corpus_Leiomyoma	Uterine Corpus Leiomyomatosis
C40172	Uterine_Corpus_Dissecting_Leiomyoma	Uterine_Corpus_Leiomyoma	Uterine Corpus Dissecting Leiomyoma
C40173	Benign_Metastasizing_Leiomyoma	Metastatic_Benign_Neoplasm|Uterine_Corpus_Leiomyoma	Benign Metastasizing Leiomyoma of the Uterine Corpus
C40174	Uterine_Corpus_Epithelioid_Leiomyosarcoma	Epithelioid_Leiomyosarcoma|Uterine_Corpus_Leiomyosarcoma	Uterine Corpus Epithelioid Leiomyosarcoma
C40175	Uterine_Corpus_Myxoid_Leiomyosarcoma	Myxoid_Leiomyosarcoma|Uterine_Corpus_Leiomyosarcoma	Uterine Corpus Myxoid Leiomyosarcoma
C40176	Uterine_Corpus_Smooth_Muscle_Neoplasm	Smooth_Muscle_Neoplasm|Uterine_Corpus_Soft_Tissue_Neoplasm	Uterine Corpus Smooth Muscle Neoplasm
C40177	Uterine_Corpus_Smooth_Muscle_Neoplasm_of_Uncertain_Malignant_Potential	Intermediate_Soft_Tissue_Neoplasm|Uterine_Corpus_Smooth_Muscle_Neoplasm	Uterine Corpus Smooth Muscle Neoplasm of Uncertain Malignant Potential
C40178	Mixed_Endometrial_Stromal_and_Smooth_Muscle_Neoplasm	Uterine_Corpus_Soft_Tissue_Neoplasm	Mixed Endometrial Stromal and Smooth Muscle Neoplasm|Mixed Endometrial Stromal and Smooth Muscle Tumor|Stromomyoma
C40179	Uterine_Corpus_Soft_Tissue_Neoplasm	Soft_Tissue_Neoplasm|Uterine_Corpus_Neoplasm	Uterine Corpus Soft Tissue Neoplasm
C40180	Uterine_Corpus_Perivascular_Epithelioid_Cell_Tumor	Neoplasm_with_Perivascular_Epithelioid_Cell_Differentiation|Uterine_Corpus_Soft_Tissue_Neoplasm	Uterine Corpus Perivascular Epithelioid Cell Tumor|Uterine Corpus PEComa
C40181	Uterine_Corpus_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Mixed_Neoplasm|Uterine_Corpus_Neoplasm	Uterine Corpus Mixed Epithelial and Mesenchymal Neoplasm|Uterine Corpus Mixed Epithelial and Mesenchymal Tumor
C40182	Uterine_Corpus_Adenocarcinofibroma	Adenocarcinofibroma|Malignant_Uterine_Corpus_Mixed_Neoplasm	Uterine Corpus Adenocarcinofibroma
C40183	Placental_Site_Nodule_or_Plaque	Non-Neoplastic_Non-Molar_Trophoblastic_Disorder	Placental Site Nodule or Plaque
C40184	Non-Neoplastic_Non-Molar_Trophoblastic_Disorder	Placental_Non-Neoplastic_Disorder	Non-Neoplastic, Non-Molar Trophoblastic Disorder
C40185	Fore-Brain	Brain_Part	Fore-Brain|Forebrain
C40186	Digit	Extremity_Part	Digit
C40187	Keratinizing_Cervical_Squamous_Cell_Carcinoma	Cervical_Squamous_Cell_Carcinoma	Cervical Keratinizing Squamous Cell Carcinoma
C40188	Non-Keratinizing_Cervical_Squamous_Cell_Carcinoma	Cervical_Squamous_Cell_Carcinoma	Cervical Non-Keratinizing Squamous Cell Carcinoma
C40189	Basaloid_Cervical_Squamous_Cell_Carcinoma	Basaloid_Carcinoma|Cervical_Squamous_Cell_Carcinoma	Cervical Basaloid Carcinoma|Cervical Basaloid Squamous Cell Carcinoma
C40190	Cervical_Verrucous_Carcinoma	Cervical_Squamous_Cell_Carcinoma|Verrucous_Carcinoma	Cervical Verrucous Carcinoma
C40191	Cervical_Warty_Carcinoma	Human_Papilloma_Virus-Related_Cervical_Squamous_Cell_Carcinoma	Cervical Warty Carcinoma|Cervical Condylomatous Squamous Cell Carcinoma|Cervical Warty Squamous Cell Carcinoma
C40192	Cervical_Papillary_Squamous_Cell_Carcinoma	Human_Papilloma_Virus-Related_Cervical_Squamous_Cell_Carcinoma|Papillary_Squamous_Cell_Carcinoma	Cervical Papillary Squamous Cell Carcinoma
C40193	Cervical_Lymphoepithelioma-like_Carcinoma	Cervical_Squamous_Cell_Carcinoma|Lymphoepithelioma-Like_Carcinoma	Cervical Lymphoepithelioma-Like Carcinoma
C40194	Cervical_Squamotransitional_Carcinoma	Human_Papilloma_Virus-Related_Cervical_Squamous_Cell_Carcinoma	Cervical Squamotransitional Carcinoma
C40195	Cervical_Squamous_Neoplasm	Cervical_Neoplasm|Squamous_Cell_Neoplasm	Cervical Squamous Neoplasm|Cervical Squamous Tumor
C40196	Low-Grade_Cervical_Squamous_Intraepithelial_Neoplasia	Cervical_Squamous_Intraepithelial_Neoplasia|Low-Grade_Cervical_Intraepithelial_Neoplasia	Low Grade Cervical Squamous Intraepithelial Neoplasia|Cervical Squamous Intraepithelial Neoplasia 1|Low-Grade CIN|Low-Grade Cervical SIL|Low-Grade Cervical Squamous Intraepithelial Lesion|Mild Squamous Dysplasia of the Cervix
C40197	High-Grade_Cervical_Squamous_Intraepithelial_Neoplasia	Cervical_Squamous_Intraepithelial_Neoplasia|High_Grade_Cervical_Intraepithelial_Neoplasia	High Grade Cervical Squamous Intraepithelial Neoplasia|High-Grade CIN|High-Grade Cervical SIL|High-Grade Cervical Squamous Intraepithelial Lesion
C40198	Cervical_Squamous_Intraepithelial_Neoplasia_2	High-Grade_Cervical_Squamous_Intraepithelial_Neoplasia	Cervical Squamous Intraepithelial Neoplasia 2|CIN 2|Moderate Squamous Dysplasia of the Cervix
C40199	Cervical_Squamous_Intraepithelial_Neoplasia_1	Low-Grade_Cervical_Squamous_Intraepithelial_Neoplasia	Cervical Squamous Intraepithelial Neoplasia 1|CIN 1
C40200	Cervical_Fibroepithelial_Polyp	Cervical_Non-Neoplastic_Disorder|Cervical_Polyp|Fibroepithelial_Polyp	Cervical Fibroepithelial Polyp|Uterine Cervix Fibroepithelial Polyp
C40201	Cervical_Serous_Adenocarcinoma	Cervical_Adenocarcinoma|Serous_Adenocarcinoma	Cervical Serous Adenocarcinoma
C40202	Cervical_Mucinous_Adenocarcinoma_Endocervical_Type	Cervical_Mucinous_Adenocarcinoma	Cervical Mucinous Adenocarcinoma, Endocervical Type
C40203	Cervical_Mucinous_Adenocarcinoma_Intestinal_Variant	Cervical_Mucinous_Adenocarcinoma	Cervical Mucinous Adenocarcinoma, Intestinal Variant
C40205	Cervical_Mucinous_Adenocarcinoma_Signet_Ring_Cell_Variant	Cervical_Mucinous_Adenocarcinoma	Cervical Mucinous Adenocarcinoma, Signet Ring Cell Variant
C40206	Cervical_Mucinous_Adenocarcinoma_Minimal_Deviation_Variant	Cervical_Mucinous_Adenocarcinoma	Cervical Mucinous Adenocarcinoma, Minimal Deviation Variant|Cervical Adenoma Malignum
C40207	Copy_Number_Polymorphism	Genetic_Polymorphism	Copy Number Polymorphism|CNP	Copy Number Polymorphism consists of variation in the number of copies of a particular sequence within the genetic material of an individual. Large-scale copy number polymorphisms are common and widely distributed in the human genome.
C40208	Cervical_Mucinous_Adenocarcinoma_Villoglandular_Variant	Cervical_Mucinous_Adenocarcinoma	Cervical Mucinous Adenocarcinoma, Villoglandular Variant
C40209	Cervical_Glandular_Dysplasia	Dysplasia	Cervical Glandular Dysplasia
C40210	Cervical_Glandular_Neoplasm	Cervical_Neoplasm|Glandular_Cell_Neoplasm	Cervical Glandular Neoplasm|Cervical Glandular Tumor
C40211	Representational_Oligonucleotide_Microarray_Analysis	Microarray_Analysis	Representational Oligonucleotide Microarray Analysis|ROMA	A genomic microarray-based method able to identify regions in the cancer genome that have undergone copy number fluctuation. This method is reported to be highly sensitive and quantitative, able to detect loss of a single allele. See: Genome Res. 2003 Oct;13(10):2291-305. Epub 2003 Sep 15.
C40212	Cervical_Adenosquamous_Carcinoma_Glassy_Cell_Variant	Cervical_Adenosquamous_Carcinoma	Cervical Adenosquamous Carcinoma, Glassy Cell Variant
C40213	Cervical_Adenoid_Basal_Carcinoma	Cervical_Carcinoma	Cervical Adenoid Basal Carcinoma
C40214	Cervical_Large_Cell_Neuroendocrine_Carcinoma	Cervical_Carcinoma|Large_Cell_Neuroendocrine_Carcinoma	Cervical Large Cell Neuroendocrine Carcinoma
C40215	Cervical_Mullerian_Papilloma	Benign_Cervical_Neoplasm|Cervical_Glandular_Neoplasm	Cervical Mullerian Papilloma
C40216	Cervical_Soft_Tissue_Neoplasm	Cervical_Neoplasm|Soft_Tissue_Neoplasm	Cervical Soft Tissue Neoplasm|Cervical Soft Tissue Tumor
C40217	Uterine_Corpus_Endometrial_Stromal_Neoplasm	Endometrial_Stromal_Neoplasm|Uterine_Corpus_Soft_Tissue_Neoplasm	Uterine Corpus Endometrial Stromal Neoplasm|Uterine Corpus Endometrial Stromal Tumor
C40218	Endometrial_Stromal_Neoplasm_of_the_Cervix	Cervical_Soft_Tissue_Neoplasm|Endometrial_Stromal_Neoplasm	Endometrial Stromal Neoplasm of the Cervix|Endometrial Stromal Tumor of the Cervix
C40219	Uterine_Corpus_Endometrial_Stromal_Sarcoma	Endometrial_Stromal_Sarcoma|Uterine_Corpus_Endometrial_Stromal_Neoplasm|Uterine_Corpus_Sarcoma	Uterine Corpus Endometrial Stromal Sarcoma
C40220	Endometrial_Stromal_Sarcoma_of_the_Cervix	Endometrial_Stromal_Neoplasm_of_the_Cervix|Endometrial_Stromal_Sarcoma|Malignant_Cervical_Neoplasm	Endometrial Stromal Sarcoma of the Cervix
C40222	Low_Grade_Endometrial_Stromal_Sarcoma_of_the_Cervix	Endometrial_Stromal_Sarcoma_of_the_Cervix|Low_Grade_Endometrial_Stromal_Sarcoma	Low Grade Endometrial Stromal Sarcoma of the Cervix
C40223	Uterine_Corpus_Low_Grade_Endometrial_Stromal_Sarcoma	Low_Grade_Endometrial_Stromal_Sarcoma|Uterine_Corpus_Endometrial_Stromal_Sarcoma	Uterine Corpus Low Grade Endometrial Stromal Sarcoma
C40224	Undifferentiated_Endocervical_Sarcoma	Cervical_Soft_Tissue_Neoplasm|Malignant_Cervical_Neoplasm|Soft_Tissue_Sarcoma	Undifferentiated Endocervical Sarcoma|Undifferentiated Sarcoma of the Endocervix
C40225	Cervical_Alveolar_Soft_Part_Sarcoma	Alveolar_Soft_Part_Sarcoma|Cervical_Soft_Tissue_Neoplasm|Malignant_Cervical_Neoplasm	Cervical Alveolar Soft Part Sarcoma
C40226	Cervical_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Cervical_Neoplasm|Mixed_Neoplasm	Cervical Mixed Epithelial and Mesenchymal Neoplasm
C40227	Benign_Cervical_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Benign_Cervical_Neoplasm|Cervical_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Benign Cervical Mixed Epithelial and Mesenchymal Neoplasm
C40228	Malignant_Cervical_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Cervical_Mixed_Epithelial_and_Mesenchymal_Neoplasm|Malignant_Cervical_Neoplasm|Malignant_Mixed_Neoplasm	Malignant Cervical Mixed Epithelial and Mesenchymal Neoplasm
C40229	Cervical_Mullerian_Adenosarcoma	Malignant_Cervical_Mixed_Epithelial_and_Mesenchymal_Neoplasm|Mullerian_Adenosarcoma	Cervical Adenosarcoma|Cervical Mullerian Adenosarcoma
C40230	Cervical_Adenofibroma	Adenofibroma|Benign_Cervical_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Cervical Adenofibroma
C40231	Cervical_Adenomyoma	Adenomyoma|Benign_Cervical_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Cervical Adenomyoma
C40232	Cervical_Adenomyoma_Endocervical_Type	Cervical_Adenomyoma	Cervical Adenomyoma, Endocervical Type
C40233	Cervical_Adenomyoma_Endometrial_Type	Cervical_Adenomyoma	Cervical Adenomyoma, Endometrial Type
C40234	Cervical_Atypical_Polypoid_Adenomyoma	Atypical_Polypoid_Adenomyoma|Cervical_Adenomyoma	Cervical Atypical Polypoid Adenomyoma
C40235	Uterine_Corpus_Atypical_Polypoid_Adenomyoma	Atypical_Polypoid_Adenomyoma|Uterine_Corpus_Adenomyoma	Uterine Corpus Atypical Polypoid Adenomyoma
C40236	Cervical_Wilms_Tumor	Malignant_Cervical_Mixed_Epithelial_and_Mesenchymal_Neoplasm|Wilms_Tumor	Cervical Wilms' Tumor|Cervical Wilms Tumor
C40239	Cervical_Melanoma	Malignant_Cervical_Neoplasm|Melanoma	Cervical Melanoma|Melanoma of the Cervix
C40240	Cervical_Blue_Nevus	Benign_Cervical_Neoplasm|Blue_Nevus|Nevus_of_External_Female_Genitalia	Cervical Blue Nevus|Blue Nevus of the Cervix
C40241	Cervical_Disorder	Uterine_Disorder	Cervical Disorder
C40242	Vaginal_Squamous_Neoplasm	Squamous_Cell_Neoplasm|Vaginal_Neoplasm	Vaginal Squamous Neoplasm|Vaginal Squamous Tumor
C40243	Vaginal_Keratinizing_Squamous_Cell_Carcinoma	Vaginal_Squamous_Cell_Carcinoma	Vaginal Keratinizing Squamous Cell Carcinoma
C40244	Vaginal_Non-Keratinizing_Squamous_Cell_Carcinoma	Vaginal_Squamous_Cell_Carcinoma	Vaginal Non-Keratinizing Squamous Cell Carcinoma
C40245	Vaginal_Basaloid_Carcinoma	Basaloid_Carcinoma|Vaginal_Squamous_Cell_Carcinoma	Vaginal Basaloid Carcinoma|Vaginal Basaloid Squamous Cell Carcinoma
C40246	_1q44	Chromosome_Band	1q44	A chromosome band present on 1q
C40247	SMYD3_Gene	Transcription_Factor_Gene	SMYD3 Gene|FLJ21080|SET and MYND Domain Containing 3 Gene|SMYD3|ZMYND1|ZNFN3A1	Expressed in testis and skeletal muscle (1.7-kb mRNA), human SMYD3 Gene encodes 428-aa 49-kDa Zinc Finger MYND Domain Containing Protein 1, a CCCTCC promoter-binding histone methyltransferase and transcriptional regulator that contains an N-terminal MYND-type zinc finger domain followed by a SET domain. Cytoplasmic at G0/G1 and nuclear at S and G2/M, SMYD3 appears to enhance cell proliferation. Through interaction with RNA helicase HELZ, SMYD3 forms a complex with RNA polymerase II. Enhanced by heat-shock protein HSP90A, the SET domain shows histone H3 lys4-specific methyltransferase activity and transcriptional activation of oncogenes, homeobox genes, and cell-cycle regulation genes. (NCI)
C40248	Vaginal_Warty_Carcinoma	Vaginal_Squamous_Cell_Carcinoma	Vaginal Warty Carcinoma
C40249	Zinc_Finger_MYND_Domain_Containing_Protein-1	Transcription_Factor	Zinc Finger MYND Domain Containing Protein 1|SET and MYND Domain Containing 3|SET and MYND Domain Containing Protein 3|SMYD3|Zinc Finger MYND Domain Containing 1|Zinc Finger Protein Subfamily 3A (MYND Domain Containing) 1	Expressed in testis and skeletal muscle by human SMYD3 Gene, 428-aa 49-kDa Zinc Finger MYND Domain Containing Protein 1 is a CCCTCC promoter-binding histone methyltransferase and transcriptional regulator that contains an N-terminal MYND-type zinc finger domain followed by a SET domain. Cytoplasmic at G0/G1 and nuclear at S and G2/M, SMYD3 appears to enhance cell proliferation. Through interaction with RNA helicase HELZ, SMYD3 forms a complex with RNA polymerase II. Enhanced by heat-shock protein HSP90A, the SET domain shows histone H3 lys4-specific methyltransferase activity and transcriptional activation of oncogenes, homeobox genes, and cell-cycle regulation genes. (NCI)
C40250	Vaginal_Glandular_Neoplasm	Glandular_Cell_Neoplasm|Vaginal_Neoplasm	Vaginal Glandular Neoplasm|Vaginal Glandular Tumor
C40251	Vaginal_Endometrioid_Adenocarcinoma	Endometrioid_Carcinoma|Vaginal_Adenocarcinoma	Vaginal Endometrioid Adenocarcinoma
C40252	Vaginal_Mucinous_Adenocarcinoma	Mucinous_Adenocarcinoma|Vaginal_Adenocarcinoma	Vaginal Mucinous Adenocarcinoma
C40253	Vaginal_Mesonephric_Adenocarcinoma	Mesonephric_Adenocarcinoma|Vaginal_Adenocarcinoma	Vaginal Mesonephric Adenocarcinoma|Gartner Duct Adenocarcinoma
C40254	Cervical_Mesonephric_Adenocarcinoma	Cervical_Adenocarcinoma|Mesonephric_Adenocarcinoma	Cervical Mesonephric Adenocarcinoma|Wolffian Duct Adenocarcinoma
C40255	Vaginal_Mullerian_Papilloma	Benign_Vaginal_Neoplasm|Vaginal_Glandular_Neoplasm	Vaginal Mullerian Papilloma
C40256	Vaginal_Adenoma	Adenoma|Vaginal_Glandular_Neoplasm	Vaginal Adenoma
C40257	Vaginal_Tubular_Adenoma	Vaginal_Adenoma	Vaginal Tubular Adenoma
C40258	Vaginal_Tubulovillous_Adenoma	Vaginal_Adenoma	Vaginal Tubulovillous Adenoma
C40259	Vaginal_Villous_Adenoma	Vaginal_Adenoma	Vaginal Villous Adenoma
C40260	Vaginal_Adenosquamous_Carcinoma	Adenosquamous_Carcinoma|Vaginal_Carcinoma	Vaginal Adenosquamous Carcinoma
C40261	Vaginal_Adenoid_Cystic_Carcinoma	Adenoid_Cystic_Carcinoma|Vaginal_Carcinoma	Vaginal Adenoid Cystic Carcinoma
C40262	Vaginal_Adenoid_Basal_Carcinoma	Vaginal_Carcinoma	Vaginal Adenoid Basal Carcinoma
C40263	Vaginal_Small_Cell_Carcinoma	Small_Cell_Carcinoma|Vaginal_Carcinoma	Vaginal Small Cell Carcinoma
C40264	Vaginal_Undifferentiated_Carcinoma	Undifferentiated_Carcinoma|Vaginal_Carcinoma	Vaginal Undifferentiated Carcinoma
C40265	Vaginal_Soft_Tissue_Neoplasm	Soft_Tissue_Neoplasm|Vaginal_Neoplasm	Vaginal Soft Tissue Neoplasm|Vaginal Soft Tissue Tumor
C40266	Cervical_Rhabdomyoma	Benign_Cervical_Neoplasm|Cervical_Soft_Tissue_Neoplasm|Genital_Rhabdomyoma	Cervical Rhabdomyoma
C40267	Adult_Botryoid-Type_Embryonal_Rhabdomyosarcoma_of_the_Vagina	Adult_Botryoid-Type_Embryonal_Rhabdomyosarcoma|Botryoid-Type_Embryonal_Rhabdomyosarcoma_of_the_Vagina	Adult Botryoid-Type Embryonal Rhabdomyosarcoma of the Vagina|Adult Sarcoma Botryoides of the Vagina
C40268	Botryoid-Type_Embryonal_Rhabdomyosarcoma_of_the_Vagina	Botryoid-Type_Embryonal_Rhabdomyosarcoma|Vaginal_Sarcoma	Botryoid-Type Embryonal Rhabdomyosarcoma of the Vagina|Sarcoma Botryoides of the Vagina
C40269	Endometrial_Stromal_Neoplasm_of_the_Vagina	Endometrial_Stromal_Neoplasm|Vaginal_Soft_Tissue_Neoplasm	Endometrial Stromal Neoplasm of the Vagina|Endometrial Stromal Tumor of the Vagina
C40270	Endometrial_Stromal_Sarcoma_of_the_Vagina	Endometrial_Stromal_Neoplasm_of_the_Vagina|Endometrial_Stromal_Sarcoma|Vaginal_Sarcoma	Endometrial Stromal Sarcoma of the Vagina
C40271	Low_Grade_Endometrial_Stromal_Sarcoma_of_the_Vagina	Endometrial_Stromal_Sarcoma_of_the_Vagina|Low_Grade_Endometrial_Stromal_Sarcoma	Low Grade Endometrial Stromal Sarcoma of the Vagina
C40272	Vaginal_Undifferentiated_Sarcoma	Vaginal_Sarcoma	Vaginal Undifferentiated Sarcoma
C40273	Vaginal_Deep_Angiomyxoma	Aggressive_Angiomyxoma|Vaginal_Soft_Tissue_Neoplasm	Vaginal Deep Angiomyxoma|Vaginal Aggressive Angiomyxoma
C40274	Vaginal_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Mixed_Neoplasm|Vaginal_Neoplasm	Vaginal Mixed Epithelial and Mesenchymal Neoplasm|Vaginal Mixed Epithelial and Mesenchymal Tumor
C40275	Benign_Vaginal_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Benign_Vaginal_Neoplasm|Vaginal_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Benign Vaginal Mixed Epithelial and Mesenchymal Neoplasm|Benign Vaginal Mixed Epithelial and Mesenchymal Tumor
C40276	Malignant_Vaginal_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Malignant_Mixed_Neoplasm|Malignant_Vaginal_Neoplasm|Vaginal_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Malignant Vaginal Mixed Epithelial and Mesenchymal Neoplasm|Malignant Vaginal Mixed Epithelial and Mesenchymal Tumor
C40277	Vaginal_Adenosarcoma	Malignant_Vaginal_Mixed_Epithelial_and_Mesenchymal_Neoplasm|Mullerian_Adenosarcoma	Vaginal Adenosarcoma|Vaginal Mullerian Adenosarcoma
C40278	Vaginal_Carcinosarcoma	Malignant_Mixed_Mesodermal_Mullerian_Tumor|Malignant_Vaginal_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Vaginal Carcinosarcoma|Vaginal Malignant Mixed Mesodermal (Mullerian) Tumor
C40279	Malignant_Vaginal_Mixed_Tumor_Resembling_Synovial_Sarcoma	Malignant_Vaginal_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Malignant Vaginal Mixed Tumor Resembling Synovial Sarcoma
C40280	Benign_Vaginal_Mixed_Tumor	Benign_Vaginal_Mixed_Epithelial_and_Mesenchymal_Neoplasm	Benign Vaginal Mixed Tumor|Vaginal Spindle Cell Epithelioma
C40281	Benign_Vaginal_Melanocytic_Nevus	Benign_Melanocytic_Nevus|Benign_Vaginal_Neoplasm|Nevus_of_External_Female_Genitalia	Benign Vaginal Melanocytic Nevus
C40282	Vaginal_Blue_Nevus	Benign_Vaginal_Melanocytic_Nevus|Blue_Nevus	Vaginal Blue Nevus
C40283	Vulvar_Squamous_Neoplasm	Squamous_Cell_Neoplasm|Vulvar_Neoplasm	Vulvar Squamous Neoplasm|Vulvar Squamous Tumor
C40284	Vulvar_Keratinizing_Squamous_Cell_Carcinoma	Vulvar_Squamous_Cell_Carcinoma	Vulvar Keratinizing Squamous Cell Carcinoma
C40285	Vulvar_Non-Keratinizing_Squamous_Cell_Carcinoma	Vulvar_Squamous_Cell_Carcinoma	Vulvar Non-Keratinizing Squamous Cell Carcinoma
C40286	Vulvar_Basaloid_Carcinoma	Basaloid_Carcinoma|Vulvar_Squamous_Cell_Carcinoma	Vulvar Basaloid Carcinoma|Vulvar Basaloid Squamous Cell Carcinoma
C40287	Vulvar_Warty_Carcinoma	Human_Papilloma_Virus-Related_Vulvar_Squamous_Cell_Carcinoma	Vulvar Warty Carcinoma|Vulvar Condylomatous Carcinoma
C40288	Vulvar_Keratoacanthoma-like_Carcinoma	Vulvar_Squamous_Cell_Carcinoma	Vulvar Keratoacanthoma-like Carcinoma
C40289	Vulvar_Squamous_Cell_Carcinoma_with_Tumor_Giant_Cells	Vulvar_Squamous_Cell_Carcinoma	Vulvar Squamous Cell Carcinoma with Tumor Giant Cells
C40290	Vestibular_Micropapillomatosis	Vulvar_Squamous_Papilloma	Vestibular Micropapillomatosis|Micropapillomatosis Labialis
C40291	Vulvar_Inverted_Follicular_Keratosis	Inverted_Follicular_Keratosis|Vulvar_Seborrheic_Keratosis	Vulvar Inverted Follicular Keratosis
C40292	Vulvar_Glandular_Neoplasm	Glandular_Cell_Neoplasm|Vulvar_Neoplasm	Vulvar Glandular Neoplasm|Vulvar Glandular Tumor
C40293	Bartholin_s_Gland_Squamous_Cell_Carcinoma	Bartholin_s_Gland_Carcinoma|Vulvar_Squamous_Cell_Carcinoma	Bartholin's Gland Squamous Cell Carcinoma
C40295	Bartholin_s_Gland_Adenoid_Cystic_Carcinoma	Adenoid_Cystic_Carcinoma|Bartholin_s_Gland_Carcinoma	Bartholin's Gland Adenoid Cystic Carcinoma
C40296	Bartholin_s_Gland_Adenosquamous_Carcinoma	Adenosquamous_Carcinoma|Bartholin_s_Gland_Carcinoma	Bartholin's Gland Adenosquamous Carcinoma
C40297	Bartholin_s_Gland_Transitional_Cell_Carcinoma	Bartholin_s_Gland_Carcinoma|Transitional_Cell_Carcinoma	Bartholin's Gland Transitional Cell Carcinoma
C40298	Bartholin_s_Gland_Small_Cell_Carcinoma	Bartholin_s_Gland_Carcinoma|Small_Cell_Carcinoma	Bartholin's Gland Small Cell Carcinoma
C40299	Bartholin_s_Gland_Adenoma	Adenoma|Benign_Bartholin_s_Gland_Neoplasm|Vulvar_Glandular_Neoplasm	Bartholin's Gland Adenoma
C40300	Bartholin_s_Gland_Adenomyoma	Benign_Bartholin_s_Gland_Neoplasm|Vulvar_Glandular_Neoplasm	Bartholin's Gland Adenomyoma
C40301	Adenoma_of_Minor_Vestibular_Glands	Adenoma|Benign_Vulvar_Neoplasm|Vulvar_Glandular_Neoplasm	Adenoma of Minor Vestibular Glands
C40302	Benign_Mixed_Tumor_of_the_Vulva	Benign_Mixed_Tumor_of_the_Skin_Chondroid_Syringoma|Benign_Vulvar_Neoplasm	Benign Mixed Tumor of the Vulva|Chondroid Syringoma of the Vulva
C40303	Vulvar_Tumor_of_Skin_Appendage_Origin	Skin_Appendage_Neoplasm|Vulvar_Neoplasm	Vulvar Neoplasm of Skin Appendage Origin|Vulvar Tumor of Skin Appendage Origin
C40304	Malignant_Vulvar_Sweat_Gland_Neoplasm	Malignant_Sweat_Gland_Neoplasm|Malignant_Vulvar_Neoplasm|Vulvar_Tumor_of_Skin_Appendage_Origin	Malignant Vulvar Sweat Gland Neoplasm
C40305	Vulvar_Eccrine_Adenocarcinoma	Eccrine_Adenocarcinoma|Malignant_Vulvar_Sweat_Gland_Neoplasm|Vulvar_Adenocarcinoma	Vulvar Eccrine Adenocarcinoma
C40306	Vulvar_Eccrine_Porocarcinoma	Eccrine_Porocarcinoma|Malignant_Vulvar_Sweat_Gland_Neoplasm	Vulvar Eccrine Porocarcinoma
C40307	Vulvar_Clear_Cell_Hidradenocarcinoma	Malignant_Vulvar_Sweat_Gland_Neoplasm|Sweat_Gland_Carcinoma	Vulvar Clear Cell Hidradenocarcinoma	A vulvar sweat gland carcinoma characterized by the presence of clear cells.
C40308	Vulvar_Apocrine_Adenocarcinoma	Apocrine_Carcinoma|Malignant_Vulvar_Sweat_Gland_Neoplasm|Vulvar_Adenocarcinoma	Vulvar Apocrine Adenocarcinoma
C40309	Vulvar_Sebaceous_Carcinoma	Extraocular_Cutaneous_Sebaceous_Carcinoma|Vulvar_Carcinoma|Vulvar_Tumor_of_Skin_Appendage_Origin	Vulvar Sebaceous Carcinoma
C40310	Sebaceous_Carcinoma	Adenocarcinoma|Adnexal_Carcinoma|Malignant_Sebaceous_Neoplasm	Sebaceous Carcinoma|Carcinoma of Sebaceous Gland|Carcinoma of the Sebaceous Gland|Sebaceous Gland Carcinoma
C40311	Vulvar_Syringoma	Benign_Vulvar_Neoplasm|Syringoma|Vulvar_Tumor_of_Skin_Appendage_Origin	Vulvar Syringoma
C40312	Vulvar_Nodular_Hidradenoma	Benign_Vulvar_Neoplasm|Nodular_Hidradenoma|Vulvar_Tumor_of_Skin_Appendage_Origin	Vulvar Nodular Hidradenoma
C40314	Vulvar_Trichoepithelioma	Benign_Vulvar_Neoplasm|Trichoepithelioma|Vulvar_Tumor_of_Skin_Appendage_Origin	Vulvar Trichoepithelioma
C40315	Pilomyxoid_Astrocytoma	Astrocytic_Tumor	Pilomyxoid Astrocytoma	A recently described astrocytic tumor of uncertain relation to pilocytic astrocytoma.  It occurs predominantly in infants and young children.  It is characterized by a monomorphic architectural pattern, usually associated with the absence of Rosenthal fibers and eosinophilic granular bodies.  The clinical course is usually aggressive -- 2004
C40316	Vulvar_Soft_Tissue_Neoplasm	Soft_Tissue_Neoplasm|Vulvar_Neoplasm	Vulvar Soft Tissue Neoplasm|Vulvar Soft Tissue Tumor
C40317	Vulvar_Sarcoma	Malignant_Vulvar_Neoplasm|Soft_Tissue_Sarcoma|Vulvar_Soft_Tissue_Neoplasm	Vulvar Sarcoma
C40318	Vulvar_Leiomyosarcoma	Leiomyosarcoma|Vulvar_Sarcoma	Vulvar Leiomyosarcoma
C40319	Vulvar_Proximal-Type_Epithelioid_Sarcoma	Proximal-Type_Epithelioid_Sarcoma|Vulvar_Sarcoma	Vulvar Proximal-Type Epithelioid Sarcoma
C40320	Vulvar_Alveolar_Soft_Part_Sarcoma	Alveolar_Soft_Part_Sarcoma|Vulvar_Sarcoma	Vulvar Alveolar Soft Part Sarcoma
C40321	Vulvar_Liposarcoma	Liposarcoma|Vulvar_Sarcoma	Vulvar Liposarcoma
C40322	Vulvar_Deep_Angiomyxoma	Aggressive_Angiomyxoma|Vulvar_Angiomyxoma	Vulvar Deep Angiomyxoma|Vulvar Aggressive Angiomyxoma
C40323	Superficial_Angiomyxoma	Angiomyxoma	Superficial Angiomyxoma
C40324	Vulvar_Superficial_Angiomyxoma	Superficial_Angiomyxoma|Vulvar_Angiomyxoma	Vulvar Superficial Angiomyxoma
C40325	Vulvar_Angiomyxoma	Angiomyxoma|Vulvar_Soft_Tissue_Neoplasm	Vulvar Angiomyxoma
C40326	Vulvar_Leiomyoma	Leiomyoma|Vulvar_Soft_Tissue_Neoplasm	Vulvar Leiomyoma
C40327	Vulvar_Cellular_Angiofibroma	Benign_Vulvar_Neoplasm|Cellular_Angiofibroma|Vulvar_Soft_Tissue_Neoplasm	Vulvar Cellular Angiofibroma
C40328	Vulvar_Granular_Cell_Tumor	Granular_Cell_Tumor|Vulvar_Soft_Tissue_Neoplasm	Vulvar Granular Cell Tumor
C40329	Vulvar_Melanoma	Malignant_Vulvar_Neoplasm|Melanoma|Vulvar_Melanocytic_Neoplasm	Vulvar Melanoma
C40330	Vulvar_Congenital_Melanocytic_Nevus	Benign_Melanocytic_Nevus|Benign_Vulvar_Neoplasm|Nevus_of_External_Female_Genitalia|Vulvar_Melanocytic_Neoplasm	Vulvar Congenital Melanocytic Nevus
C40331	Vulvar_Acquired_Melanocytic_Nevus	Benign_Melanocytic_Nevus|Benign_Vulvar_Neoplasm|Nevus_of_External_Female_Genitalia|Vulvar_Melanocytic_Neoplasm	Vulvar Acquired Melanocytic Nevus
C40332	Vulvar_Blue_Nevus	Benign_Vulvar_Neoplasm|Blue_Nevus|Nevus_of_External_Female_Genitalia|Vulvar_Melanocytic_Neoplasm	Vulvar Blue Nevus
C40333	Vulvar_Atypical_Melanocytic_Nevus_of_the_Genital_Type	Nevus_of_External_Female_Genitalia|Vulvar_Melanocytic_Neoplasm	Atypical Melanocytic Nevus of the Genital Type|Atypical Vulvar Nevus
C40334	Vulvar_Dysplastic_Melanocytic_Nevus	Dysplastic_Nevus|Nevus_of_External_Female_Genitalia|Vulvar_Melanocytic_Neoplasm	Vulvar Dysplastic Melanocytic Nevus
C40335	Vulvar_Melanocytic_Neoplasm	Melanocytic_Skin_Neoplasm|Vulvar_Neoplasm	Vulvar Melanocytic Neoplasm
C40336	Hind-Brain	Brain_Part	Hind-Brain
C40337	Retroperitoneal_Gastrointestinal_Stromal_Tumor	Extragastrointestinal_Gastrointestinal_Stromal_Tumor|Retroperitoneal_Neoplasm	Retroperitoneal Gastrointestinal Stromal Tumor
C40338	Peritoneal_Gastrointestinal_Stromal_Tumor	Extragastrointestinal_Gastrointestinal_Stromal_Tumor|Peritoneal_Neoplasm	Peritoneal Gastrointestinal Stromal Tumor
C40339	Mesenteric_Gastrointestinal_Stromal_Tumor	Peritoneal_Gastrointestinal_Stromal_Tumor	Mesenteric Gastrointestinal Stromal Tumor
C40340	Omentum_Gastrointestinal_Stromal_Tumor	Peritoneal_Gastrointestinal_Stromal_Tumor	Omentum Gastrointestinal Stromal Tumor
C40341	Hypospadias	Penile_Non-Neoplastic_Disorder	Hypospadias
C40342	Gene_Physical_Location	Microanatomy	Gene Physical Location	The physical location of a gene expressed as chromosome and start and end base positions as found in Entrez Gene.
C40343	Hypotriploidy	Aneuploidy	Hypotriploidy
C40344	Hypertriploidy	Aneuploidy	Hypertriploidy
C40345	Testicular_Intratubular_Germ_Cell_Neoplasia_Unclassified	Stage_0_Testicular_Cancer	Testicular Intratubular Germ Cell Neoplasia, Unclassified|Gonocytoma In Situ|IGCNU|Testicular Intraepithelial Neoplasia|Testicular Intratubular Germ Cell Neoplasia of Unclassified Type|Testicular Intratubular Germ Cell Neoplasia of the Unclassified Type
C40346	Culture_Setup	Culture_Procedure	Culture Setup	The preparation work required for doing cell or tissue culture.  This includes preparation of the medium and of the growth support material or growth chamber.
C40347	Invasive_Mixed_Breast_Carcinoma	Invasive_Breast_Carcinoma	Invasive Mixed Breast Carcinoma|Infiltrating Mixed Breast Carcinoma
C40348	Pleomorphic_Breast_Carcinoma	Grade_3_Invasive_Breast_Carcinoma|Invasive_Ductal_Carcinoma_not_Otherwise_Specified	Pleomorphic Breast Carcinoma	A rare, grade 3 (high grade) variant of invasive ductal carcinoma, not otherwise specified.  It is characterised by the presence of neoplastic bizarre and pleomorphic giant cells, which comprise at least 50% of the tumor cells. -- 2004
C40349	Breast_Carcinoma_with_Osteoclastic_Giant_Cells	Breast_Adenocarcinoma|Invasive_Breast_Carcinoma	Breast Carcinoma with Osteoclastic Giant Cells	An invasive breast adenocarcinoma characterised by the presence of non-neoplastic stromal osteoclastic giant cells.  The carcinomatous component is usually an invasive ductal carcinoma, although all other breast adenocarcinoma subtypes have also been described.  The prognosis depends on the characteristics of the adenocarcinomatous component, and is not related to the presence of the giant cells. -- 2004
C40350	Breast_Carcinoma_with_Choriocarcinomatous_Features	Invasive_Ductal_Carcinoma_not_Otherwise_Specified	Breast Carcinoma with Choriocarcinomatous Features
C40351	Breast_Carcinoma_with_Melanotic_Features	Invasive_Ductal_Carcinoma_not_Otherwise_Specified	Breast Carcinoma with Melanotic Features
C40352	Product	Conceptual_Entities	Product	A quantity obtained by multiplication.
C40353	Shipping	Clinical_or_Research_Activity	Shipping	The act or business of transporting goods.
C40354	Breast_Mucinous_Cystadenocarcinoma	Mucinous_Breast_Carcinoma|Mucinous_Cystadenocarcinoma	Breast Mucinous Cystadenocarcinoma
C40355	Breast_Columnar_Cell_Mucinous_Carcinoma	Mucinous_Breast_Carcinoma	Breast Columnar Cell Mucinous Carcinoma
C40356	Breast_Large_Cell_Neuroendocrine_Carcinoma	Breast_Neuroendocrine_Neoplasm|Invasive_Breast_Carcinoma|Large_Cell_Neuroendocrine_Carcinoma	Breast Large Cell Neuroendocrine Carcinoma
C40357	Squamous_Cell_Breast_Carcinoma_Large_Cell_Keratinizing_Variant	Squamous_Cell_Breast_Carcinoma	Squamous Cell Breast Carcinoma, Large Cell Keratinizing Variant
C40358	Squamous_Cell_Breast_Carcinoma_Spindle_Cell_Variant	Squamous_Cell_Breast_Carcinoma	Squamous Cell Breast Carcinoma, Spindle Cell Variant
C40359	Squamous_Cell_Breast_Carcinoma_Acantholytic_Variant	Squamous_Cell_Breast_Carcinoma	Squamous Cell Breast Carcinoma, Acantholytic Variant
C40360	Breast_Adenocarcinoma_with_Spindle_Cell_Metaplasia	Breast_Adenocarcinoma|Metaplastic_Breast_Carcinoma	Breast Adenocarcinoma with Spindle Cell Metaplasia
C40361	Adenosquamous_Breast_Carcinoma	Adenosquamous_Carcinoma|Metaplastic_Breast_Carcinoma	Adenosquamous Breast Carcinoma
C40362	Low_Grade_Adenosquamous_Breast_Carcinoma	Adenosquamous_Breast_Carcinoma	Low Grade Adenosquamous Breast Carcinoma|Infiltrating Breast Syringomatous Adenoma
C40363	Nipple_Syringomatous_Adenoma	Nipple_Neoplasm	Nipple Syringomatous Adenoma|Infiltrating Nipple Syringomatous Adenoma
C40364	Mixed_Epithelial_Mesenchymal_Metaplastic_Breast_Carcinoma	Metaplastic_Breast_Carcinoma	Mixed Epithelial/Mesenchymal Metaplastic Breast Carcinoma
C40365	Lipid-Rich_Breast_Carcinoma	Invasive_Breast_Carcinoma|Lipid-Rich_Carcinoma	Lipid-Rich Breast Carcinoma
C40366	Oncocytic_Breast_Carcinoma	Breast_Adenocarcinoma|Invasive_Breast_Carcinoma	Oncocytic Breast Carcinoma
C40367	Acinic_Cell_Breast_Carcinoma	Acinar_Cell_Carcinoma|Breast_Adenocarcinoma|Invasive_Breast_Carcinoma	Acinic Cell Breast Carcinoma
C40368	Glycogen-Rich_Clear_Cell_Breast_Carcinoma	Breast_Adenocarcinoma|Clear_Cell_Adenocarcinoma|Glycogen-Rich_Carcinoma|Invasive_Breast_Carcinoma	Glycogen-Rich, Clear Cell Breast Carcinoma	An uncommon, usually aggressive adenocarcinoma of the breast characterized by the presence of clear cells that contain glycogen.
C40369	Sebaceous_Breast_Carcinoma	Extraocular_Cutaneous_Sebaceous_Carcinoma|Invasive_Breast_Carcinoma	Sebaceous Breast Carcinoma
C40370	Synchronous_Bilateral_Breast_Carcinoma	Bilateral_Breast_Carcinoma	Synchronous Bilateral Breast Carcinoma
C40373	Lingula	Respiratory_System_Part	Lingula of the Lung
C40374	Microinvasive_Breast_Carcinoma	Invasive_Breast_Carcinoma	Microinvasive Breast Carcinoma
C40375	Breast_Diffuse_Large_B-Cell_Lymphoma	Breast_Lymphoma|Diffuse_Large_B-Cell_Lymphoma	Breast Diffuse Large B-Cell Lymphoma|Breast DLBCL
C40376	Breast_Burkitt_s_Lymphoma	Breast_Lymphoma|Burkitt_s_Lymphoma	Breast Burkitt's Lymphoma|Breast Burkitt Lymphoma
C40377	Breast_Follicular_Lymphoma	Breast_Lymphoma|Follicular_Lymphoma	Breast Follicular Lymphoma
C40378	Post-Radiotherapy_Breast_Angiosarcoma	Breast_Angiosarcoma	Post-Radiotherapy Breast Angiosarcoma
C40379	Angiosarcoma_of_the_Skin_of_the_Arm_after_Radical_Mastectomy_followed_by_Lymphedema	Angiosarcoma_Associated_with_Lymphedema	Angiosarcoma of the Skin of the Arm after Radical Mastectomy followed by Lymphedema|S-T Syndrome
C40380	Radial_Scar_Complex_Sclerosing_Lesion	Retired_Concepts	Radial Scar/Complex Sclerosing Lesion|Radial Scar
C40381	Breast_Angiomatosis	Benign_Breast_Neoplasm|Vascular_Breast_Neoplasm	Breast Angiomatosis
C40382	Breast_Adenoma	Adenoma|Benign_Breast_Neoplasm	Breast Adenoma
C40383	Breast_Apocrine_Adenoma	Breast_Adenoma	Breast Apocrine Adenoma
C40384	Breast_Ductal_Adenoma	Breast_Adenoma|Ductal_Adenoma	Breast Ductal Adenoma
C40385	Myoepitheliosis	Breast_Myoepithelial_Neoplasm	Breast Myoepitheliosis
C40386	Breast_Atypical_Myoepitheliosis	Atypical_Hyperplasia_of_the_Breast|Myoepitheliosis	Atypical Breast Myoepitheliosis
C40387	Intraductal_Breast_Myoepitheliosis	Ductal_Breast_Hyperplasia|Myoepitheliosis	Intraductal Breast Myoepitheliosis
C40388	Periductal_Breast_Myoepitheliosis	Myoepitheliosis	Periductal Breast Myoepitheliosis
C40389	Breast_Myoepithelial_Neoplasm	Breast_Neoplasm|Myoepithelial_Neoplasm	Breast Myoepithelial Neoplasm
C40391	Breast_Adenomyoepithelial_Adenosis	Breast_Adenosis	Breast Adenomyoepithelial Adenosis
C40392	Myoepithelial_Neoplasm	Neoplasm_by_Morphology	Myoepithelial Neoplasm|Myoepithelial Tumor
C40393	Salivary_Gland_Myoepithelial_Neoplasm	Myoepithelial_Neoplasm|Salivary_Gland_Neoplasm	Salivary Gland Myoepithelial Neoplasm|Salivary Gland Myoepithelial Tumor
C40395	Malignant_Breast_Myoepithelioma	Breast_Myoepithelial_Neoplasm|Invasive_Breast_Carcinoma|Myoepithelial_Carcinoma	Malignant Breast Myoepithelioma|Breast Myoepithelial Carcinoma
C40396	Breast_Hemangiopericytoma	Breast_Soft_Tissue_Neoplasm|Hemangiopericytoma	Breast Hemangiopericytoma
C40397	Breast_Myofibroblastoma	Benign_Breast_Neoplasm|Benign_Miscellaneous_Mesenchymal_Neoplasm|Breast_Soft_Tissue_Neoplasm	Breast Myofibroblastoma
C40398	Breast_Inflammatory_Myofibroblastic_Tumor	Breast_Soft_Tissue_Neoplasm|Inflammatory_Myofibroblastic_Tumor	Breast Inflammatory Myofibroblastic Tumor
C40399	Breast_Leiomyoma	Benign_Breast_Neoplasm|Breast_Soft_Tissue_Neoplasm|Leiomyoma	Breast Leiomyoma
C40400	Breast_Granular_Cell_Tumor	Breast_Neoplasm|Granular_Cell_Tumor	Breast Granular Cell Tumor
C40401	Breast_Hamartoma	Hamartoma|Non-Neoplastic_Breast_Disorder	Breast Hamartoma
C40402	Breast_Adenolipoma	Breast_Hamartoma	Breast Adenolipoma
C40403	Breast_Adenohibernoma	Breast_Hamartoma	Breast Adenohibernoma
C40404	Breast_Myoid_Hamartoma	Breast_Hamartoma	Breast Myoid Hamartoma
C40405	Breast_Fibroepithelial_Neoplasm	Breast_Neoplasm|Fibroepithelial_Neoplasm	Breast Fibroepithelial Neoplasm|Breast Fibroepithelial Tumor
C40406	Breast_Soft_Tissue_Neoplasm	Breast_Neoplasm|Soft_Tissue_Neoplasm	Breast Soft Tissue Neoplasm|Breast Soft Tissue Tumor
C40407	Renal_Wilms_Tumor	Malignant_Renal_Neoplasm|Wilms_Tumor	Renal Wilms' Tumor|Nephroblastoma|Renal Wilms Tumor|Wilms Tumor of the Kidney|Wilms' Tumor of the Kidney|Wilms' tumor	A kidney cancer that usually occurs in children younger than 5 years old.
C40408	Breast_Pleomorphic_Adenoma	Breast_Adenoma|Pleomorphic_Adenoma	Breast Pleomorphic Adenoma|Pleomorphic Adenoma of the Breast
C40409	Salivary_Gland_Pleomorphic_Adenoma	Benign_Salivary_Gland_Neoplasm|Mixed_Tumor_of_the_Salivary_Gland|Pleomorphic_Adenoma	Salivary Gland Pleomorphic Adenoma|Benign Mixed Salivary Gland Neoplasm|Benign Mixed Salivary Gland Tumor|Benign Mixed Salivary Neoplasm|Benign Mixed Salivary Tumor	A benign, slow-growing tumor composed of cells that demonstrate both epithelial and mesenchymal differentiation. It is the most common neoplasm of salivary gland origin, and mostly occurs in the parotid gland. The average age of patients has been reported to be 43 years; women are more often affected than men. The malignant change rate has been estimated to be 6%. The malignant counterpart is carcinoma ex pleomorphic adenoma. --2003
C40410	Salivary_Gland_Carcinoma_Ex_Pleomorphic_Adenoma	Carcinoma_Ex_Pleomorphic_Adenoma|Malignant_Mixed_Tumor_of_the_Salivary_Gland|Salivary_Gland_Carcinoma	Salivary Gland Carcinoma ex Pleomorphic Adenoma
C40411	Salivary_Gland_Myoepithelial_Cell	Myoepithelial_Cell	Salivary Gland Myoepithelial Cell
C40412	Ineligibility	Properties_or_Attributes	Ineligibility	The state or quality of being disqualified by law, rule, or provision.
C40413	No_Evidence_of_Disease	Clinical_Course_of_Disease	No Evidence of Disease|NED	Diagnostic tests fail to detect presence of disease.
C40414	Compatible	Properties_or_Attributes	Compatible	Able to exist in combination.
C40415	Pseudogene	Miscellaneous_Molecular_Biology_Terms	Pseudogene	Nonfunctional DNA sequences that are very similar to the sequences of known genes.  Many seem to have arisen as functional gene duplications that subsequently underwent mutation and loss of function.  Others are structurally similar to mRNA and seem to have arisen by a reverse transcription event followed by integration into the genome.  Some pseudogenes are transcribed and may play a role in regulation of its homologous gene.
C40416	Leakage	Conceptual_Entities	Leakage|Spillage	The unwanted discharge of a fluid from some container or vessel.
C40417	Tumor_Leakage	Leakage	Tumor Leakage|Tumor Spillage	The loss of a fluid from a tumor. This can occur under normal circumstances or during biopsy or other surgical procedure.
C40418	Abscess_Leakage	Leakage	Abscess Leakage|Abscess Spillage	The loss of a fluid from an abscess into the surrounding tissue or body cavity.
C40419	Body_Fluid_Leakage	Leakage	Body Fluid Leakage|Body Fluid Spillage	The loss of any normal body fluid into the surrounding tissue or body cavity.
C40420	Protein_Activation_Pathway	Regulatory_Pathways	Protein Activation Pathway|Positive Regulation of Protein Activity Pathway
C40421	Protein_Cycling_Pathway	Biochemical_Pathway	Protein Cycling Pathway|Protein Recycling Pathway
C40422	Other_Biochemical_Pathway	Biochemical_Pathway	Other Biochemical Pathway
C40423	Brain_Hamartoma	Central_Nervous_System_Hamartoma	Brain Hamartoma
C40424	Cartilagenous_Hamartoma	Mesenchymal_Hamartoma	Cartilagenous Hamartoma
C40425	Congenital_Hamartoma	Hamartoma	Congenital Hamartoma
C40426	Lipomatous_Hamartoma	Mesenchymal_Hamartoma	Lipomatous Hamartoma
C40427	Mesenchymal_Hamartoma	Hamartoma	Mesenchymal Hamartoma
C40428	Electron	Subatomic_Particle	Electron|Beta Particle|Negative Beta Particle
C40429	Subatomic_Particle	Inorganic_Chemical	Subatomic Particle|Elementary Particle
C40430	BRAF_Gene_Mutation	Gene_Abnormality	BRAF Gene Mutation
C40431	Proton_Radiation	Charged_Particles_Radiation	Proton Radiation|Radiation, Charged Particles-Protons	Radiation of protons during radioactive decay.
C40432	Neutron	Subatomic_Particle	Neutron	An elementary particle with 0 charge and a mass about equal to that of a proton.
C40434	Juvenile_Type_Bilateral_Ovarian_Granulosa_Cell_Tumor	Juvenile_Type_Ovarian_Granulosa_Cell_Tumor	Juvenile Type Bilateral Ovarian Granulosa Cell Tumor
C40435	Potter_Syndrome	Syndrome	Potter Syndrome
C40436	Ovarian_Sex_Cord-Stromal_Tumor_Associated_with_Peutz-Jeghers_Syndrome	Ovarian_Sex_Cord-Stromal_Tumor_of_Mixed_or_Unclassified_Cell_Types	Ovarian Sex Cord-Stromal Tumor Associated with Peutz-Jeghers Syndrome
C40438	Beck_Depression_Inventory	Symptom_Specific_Assessment_Tool	Beck Depression Inventory	A twenty-one question survey completed by a patient, with each answer scored on a scale of 0 to 3, designed to measure presence of depression.
C40439	Ovarian_Small_Cell_Carcinoma_Hypercalcemic_Type	Ovarian_Small_Cell_Carcinoma	Ovarian Small Cell Carcinoma, Hypercalcemic Type
C40440	Ovarian_Small_Cell_Carcinoma_Pulmonary_Type	Ovarian_Small_Cell_Carcinoma	Ovarian Small Cell Carcinoma, Pulmonary Type
C40442	Gestational_Ovarian_Choriocarcinoma	Ovarian_Choriocarcinoma	Gestational Ovarian Choriocarcinoma
C40443	Ovarian_Wilms_Tumor	Malignant_Ovarian_Neoplasm|Wilms_Tumor	Ovarian Wilms' Tumor|Ovarian Wilms Tumor
C40444	Ovarian_Malignant_Mesothelioma	Malignant_Mesothelioma|Malignant_Ovarian_Neoplasm	Ovarian Malignant Mesothelioma
C40445	Leuteoma_of_Pregnancy	Ovarian_Non-Neoplastic_Disorder|Pregnancy_Disorder	Leuteoma of Pregnancy
C40446	Ovarian_Stromal_Hyperthecosis	Ovarian_Non-Neoplastic_Disorder	Ovarian Stromal Hyperthecosis
C40447	Ovarian_Stromal_Hyperplasia	Ovarian_Non-Neoplastic_Disorder	Ovarian Stromal Hyperplasia
C40450	Off	Conceptual_Entities	Off	No longer planned or scheduled (said of events).
C40451	Off_Follow_Up	General_Modifier	Off Follow-up|Off Follow-Up	No longer participating in the follow-up phase of a study; not being followed.
C40455	Hereditary_Fallopian_Tube_Carcinoma	Fallopian_Tube_Carcinoma|Familial_Cancer	Hereditary Fallopian Tube Carcinoma|Familiar Fallopian Tube Carcinoma
C40457	ABC_Transporter_Interaction	Active_Transporter_Interaction	ABC Transporter Binding	ABC Transporter Binding involves temporary non-covalent interaction of a molecule through intermolecular physical forces of attraction with a protein complex that, after conformational change, moves a bound substrate across a cell membrane against a concentration gradient resulting directly from the expenditure of energy. ABC Transporter complexes consist of two conserved six-transmembrane proteins (permeases), two conserved ATP-hydrolyzing peripheral membrane proteins, and a periplasmic substrate-binding protein.
C40458	CHEK2_Gene_Mutation	Gene_Abnormality	CHEK2 Gene Mutation
C40459	ATM_Gene_Mutation	Gene_Abnormality	ATM Gene Mutation
C40460	Cafe_Au_Lait_Patch	Skin_Patches	Cafe Au Lait Patch|Cafe Au Lait Spot
C40461	Cerebral_Calcification	Calcification	Cerebral Calcification
C40462	TSC1_Tumor-Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	TSC1 Gene Inactivation|TSC1 Tumor-Suppressor Gene Inactivation
C40463	Turcot_Syndrome_Type_1	Turcot_Syndrome	Turcot Syndrome Type 1
C40464	Turcot_Syndrome_Type_2	Turcot_Syndrome	Turcot Syndrome Type 2
C40465	Jaw_Keratocyst	Cyst	Jaw Keratocyst
C40466	Active_Transporter_Interaction	Molecular_Interaction	Active Transporter Interaction	Active Transporter Interaction involves temporary non-covalent binding of a molecule through intermolecular physical forces of attraction with a protein that, after conformational change, moves a bound substrate across a cell membrane with (symport) or against (antiport) a concentration gradient resulting directly from the expenditure of energy.
C40468	Alkylating_Activity	Biochemical_Reaction	Alkylation	Alkylating Activity in biological systems is typically a process of covalent bonding in which a chemical substance replaces hydrogen atom(s) in biologically active molecules with alkyl radical(s), hindering proper function. DNA alkylation results in strand cross-linking and can inhibit DNA replication.
C40469	Amino_Acid_Receptor_Interaction	Receptor_Interaction	Amino Acid Receptor Binding	Amino Acid Receptor Interaction involves non-covalent binding through intermolecular physical forces of attraction with a group of intrinsic membrane proteins that bind to and mediate the biological effects of small organic compounds containing an amino and carboxyl group that act as neurotransmitters (e.g., glutamic acid or aspartic acid) through modification of the activity of signal transduction pathways in target cells.
C40471	Angiotensin_Receptor_Interaction	Receptor_Interaction	Angiotensin Receptor Binding	Angiotensin Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of intrinsic membrane proteins that mediate the vasopressor effects of secreted Angiotensin signaling molecules through modification of the activity of signal transduction pathways.
C40472	Anion_Transporter_Interaction	Active_Transporter_Interaction	Anion Transporter Binding	Anion Transporter Binding involves temporary non-covalent interaction of a molecule through intermolecular physical forces of attraction with a protein that, after conformational change, moves a bound ion carrying a negative charge across a cell membrane with (symport) or against (antiport) a concentration gradient resulting directly from the expenditure of energy.
C40473	Antidiuretic_Hormone_Receptor_Interaction	Receptor_Interaction	Antidiuretic Hormone Receptor Binding	Antidiuretic Hormone Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of intrinsic membrane proteins that mediate the urine suppressing effects of Antidiuretic Hormone signaling molecules through modification of the activity of signal transduction pathways.
C40474	Antigen_Binding_Interaction	Molecular_Interaction	Antigen Binding	Antigen Binding Interaction involves specific and high affinity non-covalent interaction (binding) of an endogenous antibody through intermolecular physical forces of attraction and spatial complementarity with a soluble or particulate substance (antigen) that induces an immune response.
C40475	Antigen_Presentation_Interaction	Antigen_Binding_Interaction	Antigen Presentation Interaction	Antigen Presentation Interaction involves specific non-covalent interaction (binding) through intermolecular physical forces of attraction and spatial complementarity of T-Cell Antigen Receptors with proteolytically processed fragments of antigenic foreign proteins displayed in association with self MHC antigens on the surface of antigen presenting macrophages.
C40476	B-Cell_Receptor_Interaction	Receptor_Interaction	B-Cell Receptor Binding	B-Cell Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity between antigens and intrinsic membrane immunoglobulins that mediate antigen activation of B cells through modification of the activity of signal transduction pathways.
C40481	Calcium_Channel_Interaction	Receptor_Interaction	Calcium Channel Binding	Calcium Channel Binding involves temporary non-covalent interaction through intermolecular physical forces of attraction with cell membrane glycoproteins selectively permeable to calcium ions.
C40483	Chelating_Activity	Molecular_Interaction	Chelating Activity	Chelating Activity involves non-covalent, often coordination, bonding between a chemical element and a biological molecule or complex.
C40484	Chloride_Channel_Interaction	Receptor_Interaction	Chloride Channel Binding	Chloride Channel Binding involves temporary non-covalent interaction through intermolecular physical forces of attraction with cell membrane glycoproteins selectively permeable to chloride ions.
C40485	Copper_Chelating	Metal_Ion_Binding	Copper Chelation	Copper Chelation involves non-covalent coordination bonding between the central heavy metal trace element (atomic symbol Cu) with atomic number 29 and an organic chemical, often as part of an enzyme.
C40486	Cyclooxygenase_Interaction	Enzyme_Interaction	Cyclooxygenase Interaction	Cyclooxygenase Interaction involves temporary non-covalent binding, typically through intermolecular physical forces of attraction and spatial complementarity, between a molecular entity and Cyclooxygenase, an enzyme complex that catalyzes the formation of prostaglandins from unsaturated fatty acid, molecular oxygen, and a reduced acceptor.
C40487	Cytokine_Receptor_Interaction	Receptor_Interaction	Cytokine Receptor Binding	Cytokine Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of cell surface intrinsic membrane proteins that mediate the immunoregulatory effects of secreted paracrine cytokine signaling molecules through modification of the activity of signal transduction pathways.
C40491	DNA_Groove_Binding	DNA_Binding	DNA Groove Binding	DNA Groove Binding involves temporary non-covalent interaction through intermolecular physical forces of attraction by a protein or low molecular weight ligand with double-stranded DNA in either the major or minor groove formed by the double helical structure, in either a sequence dependent or independent fashion.
C40492	DNA_Intercalation	DNA_Binding	DNA Intercalation	DNA Intercalation involves insertion by covalent linkage of a molecule into the double-stranded deoxyribonucleotide polymer between the internal purine and pyrimidine base pairs stacked one on another perpendicular to the double helix axis.
C40493	DNA_Major_Groove_Binding	DNA_Groove_Binding	DNA Major Groove Binding	DNA Major Groove Binding involves temporary non-covalent interaction through intermolecular physical forces of attraction by a protein or low molecular weight ligand with double-stranded DNA in the larger (major) groove formed between successive turns by the double helical structure, in either a sequence dependent or independent fashion.
C40494	DNA_Minor_Groove_Binding	DNA_Groove_Binding	DNA Minor Groove Binding	DNA Minor Groove Binding involves temporary non-covalent interaction through intermolecular physical forces of attraction by a protein or low molecular weight ligand with double-stranded DNA in the smaller (minor) groove formed by the two antiparallel chains of the double helical structure, in either a sequence dependent or independent fashion.
C40498	Enzyme_Interaction	Molecular_Interaction	Enzyme Interaction	Enzyme Interaction involves temporary non-covalent binding, typically through intermolecular physical forces of attraction and spatial complementarity, between a molecular entity and biological molecules, usually proteins, that possess catalytic activity. Catalytic RNA and DNA molecules have also been identified.
C40500	Enzyme_Uncoupling	Enzyme_Activity_Alteration	Enzyme Uncoupling	Through physical or functional dissociation, Enzyme Uncoupling involves alteration (typically disruption) of activity of a physically or functionally coordinated biological multiplex that possesses catalytic activity (usually protein, RNA, or DNA).
C40502	Free_Radical_Formation	Free_Radical_Alteration	Free Radical Formation	Free Radical Formation involves production in normal or pathological processes of chemically unstable, short half-life and highly reactive molecules carrying at least one unpaired or 'free' electron in the outermost electron shell. Appropriating electron(s) from a nearby molecule and damaging that molecule by altering the electron number in its outermost electron shell, Free Radicals produce tissue damage.
C40503	Free_Radical_Scavenging	Free_Radical_Suppression	Free Radical Scavenging	Free Radical Scavenging involves interference with, or restraint of, production, by ready combination with, chemically unstable, short half-life and highly reactive molecules carrying at least one unpaired or 'free' electron in the outermost electron shell. Appropriating electron(s) from a nearby molecule and damaging that molecule by altering the electron number in its outermost electron shell, Free Radicals produce tissue damage.
C40504	GABA_A_Receptor_Interaction	Chloride_Channel_Interaction	GABA A Receptor Binding	GABA A Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of intrinsic membrane proteins (class A GABA receptors) that mediate the biological effects of gamma amino butyric acid (GABA) signaling molecules through modification of the activity of signal transduction pathways.
C40505	GABA_B_Receptor_Interaction	Receptor_Interaction	GABA B Receptor Binding	GABA B Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of intrinsic membrane proteins (class B GABA receptors) that mediate the biological effects of gamma amino butyric acid (GABA) signaling molecules through modification of the activity of signal transduction pathways.
C40506	Glucagon_Receptor_Interaction	Receptor_Interaction	Glucagon Receptor Binding	Glucagon Receptor Interaction involves non-covalent binding through intermolecular physical forces of attraction with a G protein-coupled intrinsic membrane protein that binds to and mediates the biological effects of glucagon through modification of the activity of adenylyl cyclase and PI-Ca signal transduction pathways. Glucagon is a polypeptide hormone, secreted by islets of Langerhans alpha cells, that regulates blood glucose level; activates liver phosphorylase; stimulates glycogenolysis; promotes gluconeogenesis and ketogenesis; and stimulates insulin release.
C40507	Glycine_Receptor_Interaction	Chloride_Channel_Interaction	Glycine Receptor Binding	Glycine Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of intrinsic membrane proteins that mediate the fast inhibitory neurotransmitter effects of secreted glycine signaling molecules through modification of the activity of signal transduction pathways.
C40508	Growth_Factor_Interaction	Molecular_Interaction	Growth Factor Binding	Growth Factor Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction and often spatial complementarity with extracellular signaling molecules (ligands) involved in the control of target cell proliferation, survival, and differentiation.
C40510	Histamine_Receptor_Interaction	Receptor_Interaction	Histamine Receptor Binding	Histamine Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of cell surface intrinsic membrane proteins that mediate the vasodilation, smooth muscle contraction, gastric secretion, tachycardia, hypersensitivity, and neurotransmission effects of histamine signaling molecules through modification of the activity of signal transduction pathways.
C40512	Immunologic_Factor_Interaction	Molecular_Interaction	Immunologic Factor Interaction	Immunologic Factor Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction and often spatial complementarity with antibody or cytokine proteins that affect immune functions, immune responses, or inflammation.
C40514	Ion_Exchanger_Interaction	Molecular_Interaction	Ion Pump Interaction	Ion Exchanger Interaction consists of temporary non-covalent binding of a molecule through intermolecular physical forces of attraction with a membrane associated enzyme, or complex, involved in ATP-dependent transmembrane transport of a positively (cation) or negatively (anion) charged atom or radical against a concentration gradient resulting directly from the expenditure of energy.
C40515	Ionophore_Activity	Cellular_Transport_Alteration	Ionophore Activity	Ionophore Activity involves the functions of molecules that form a transmembrane channel, or act as a transmembrane carrier, and increase the ionic permeability of cell membranes.
C40516	Iron_Chelating	Metal_Ion_Binding	Iron Chelation|Iron Chelating	Iron Chelation involves non-covalent coordination bonding between a central heavy metal trace element (atomic symbol Fe) with atomic number 26 and an organic chemical, often as part of an enzyme or protein complex, as in the iron-binding porphyrin group of hemoglobin.
C40517	Leukotriene_Receptor_Interaction	Receptor_Interaction	Leukotriene Receptor Binding	Leukotriene Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of cell surface intrinsic membrane proteins that mediate the inflammatory and host defense effects of arachidonic acid-derived leukotriene signaling molecules through modification of the activity of signal transduction pathways.
C40518	Lipoprotein_Interaction	Retired_Concepts	Lipoprotein Binding
C40519	MHC_Interaction	Molecular_Interaction	MHC Interaction	MHC Interaction involves temporary non-covalent binding of a molecule through intermolecular physical forces of attraction with protein complexes on the surface of diverse cell types that typically mediate cellular cooperation in the immune response.
C40521	Muscarinic_Receptor_Interaction	Receptor_Interaction	Muscarinic Receptor Binding	Muscarinic Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of cell surface intrinsic membrane proteins, stimulated by muscarine and blocked by atropine, that mediate the biological effects of acetylcholine signaling molecules through modification of the activity of signal transduction pathways.
C40523	Nucleic_Acid_Binding	Molecular_Interaction	Nucleic Acid Binding	Nucleic Acid Binding involves temporary non-covalent interaction of a protein or low molecular weight ligand through intermolecular physical forces of attraction with DNA or RNA, in either a sequence dependent or independent fashion.
C40524	Nucleoside_Receptor_Interaction	Receptor_Interaction	Nucleoside Receptor Binding	Nucleoside Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of cell surface intrinsic membrane proteins that mediate the biological effects of purine or pyrimidine nucleoside signaling molecules through modification of the activity of signal transduction pathways.
C40525	Opioid_Receptor_Interaction	Receptor_Interaction	Opioid Receptor Binding	Opioid Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of cell surface intrinsic membrane proteins that mediate the pain suppression and neurobehavioral effects of endogenous secreted peptide opioid signaling molecules through modification of the activity of signal transduction pathways.
C40526	Osmotic_Activity	Biophysical_Process	Osmotic Activity	Osmotic Activity is a passive process in which water diffuses across a cell membrane in response to a concentration gradient.
C40527	Parathormone_Receptor_Interaction	Receptor_Interaction	Parathormone Receptor Binding	Parathormone Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of cell surface intrinsic membrane proteins that mediate the homeostatic calcium and phosphate regulation, bone metabolism regulation, and bone cell regulation by secreted parathormone through modification of the activity of signal transduction pathways.
C40528	Pituitary_Hormone_Receptor_Interaction	Receptor_Interaction	Pituitary Hormone Receptor Binding	Pituitary Hormone Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of cell surface intrinsic membrane proteins that mediate the biological effects of secreted pituitary hormone signaling molecules through modification of the activity of signal transduction pathways.
C40529	Plasminogen_Activator_Interaction	Enzyme_Interaction	Plasminogen Activator Interaction	Plasminogen Activator Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction with heterogeneous group of widely expressed lysosomal and secreted serine proteases having fibrin-binding activity that convert plasminogen to fibrinolytic plasmin. Inhibited by PAI-1, encoded by the PLAT Gene (Peptidase S1 Family), and cleaved by plasmin, tissue kallikrein, or factor XA to disulfide-linked A/B chains, tissue-type plasminogen activator plays a role in cell migration and tissue remodeling.
C40530	Potassium_Channel_Interaction	Receptor_Interaction	Potassium Channel Binding	Potassium Channel Binding involves temporary non-covalent interaction through intermolecular physical forces of attraction with several types of cell membrane glycoproteins selectively permeable to potassium ions and each with different functions.
C40532	Prostaglandin_Receptor_Interaction	Receptor_Interaction	Prostaglandin Receptor Binding	Prostaglandin Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of cell surface intrinsic membrane proteins that mediate the biological effects of arachidonic acid-derived prostaglandin signaling molecules through modification of the activity of signal transduction pathways.
C40533	Protein_Kinase_Interaction	Enzyme_Interaction	Protein Kinase Interaction	Protein Kinase Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction and spatial complementarity with members of a family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.
C40534	Protein_Kinase_Receptor_Interaction	Receptor_Interaction	Protein Kinase Receptor Binding	Protein Kinase Receptor Binding involves a temporary non-covalent and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of cell surface intrinsic membrane proteins that mediate the biological effects of highly specific secreted signaling molecules through modification of the activity of signal transduction pathways by protein conversion to phosphoprotein.
C40535	Proton_Pump_Interaction	Ion_Exchanger_Interaction	Proton Pump Interaction	Proton Pump Interaction consists of temporary non-covalent binding of a molecule through intermolecular physical forces of attraction with a membrane associated enzyme, or complex, involved in ATP-dependent transmembrane transport of protons against a concentration gradient, often in exchange for other cations, resulting directly from the expenditure of energy.
C40536	Receptor_Interaction	Molecular_Interaction	Receptor Binding	Receptor Binding involves a temporary non-covalent, typically highly specific and high affinity, interaction through intermolecular physical forces of attraction and spatial complementarity with a diverse group of intrinsic membrane or cytoplasmic proteins that mediate the biological effects of secreted regulatory signaling molecules through modification of the activity of signal transduction pathways.
C40539	Ribosomal_Interaction	Molecular_Interaction	Ribosomal Interaction	Ribosomal Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction with small 120-150A diameter cytoplasmic ribonucleoprotein organelles composed of rRNA and some 80 different proteins that, assembled as a complex (free or attached to the ER), constitute the site of protein synthesis from aminoacyl-tRNAs as directed by mRNAs.
C40540	Ribosome_Assembly_Interference	Ribosomal_Function_Inhibition	Ribosome Assembly Interference	Ribosome Assembly Interference involves inhibition or restraint of the formation of small 120-150A diameter cytoplasmic ribonucleoprotein organelles in the nucleolus and composed of rRNA and some 80 different imported cytoplasmic proteins. Assembled, exported ribosomes (free or attached to the ER) are the site of protein synthesis from aminoacyl-tRNAs as directed by mRNAs.
C40542	Serotonin_Receptor_Interaction	Receptor_Interaction	Serotonin Receptor Binding	Serotonin Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of cell surface intrinsic membrane proteins that mediate the neurotransmission, gastrointestinal, hemostatic, and cardiovascular effects of secreted serotonin signaling molecules through modification of the activity of signal transduction pathways.
C40543	Sodium_Channel_Interaction	Receptor_Interaction	Sodium Channel Binding	Sodium Channel Binding involves temporary non-covalent interaction through intermolecular physical forces of attraction with cell membrane glycoproteins selectively permeable to sodium ions. Fast sodium current is associated with the action potential in neural membranes.
C40545	Spindle_Assembly_Interaction	Molecular_Interaction	Spindle Assembly Interaction	Spindle Assembly Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction with the mitotic spindle that can affect spindle function and mitosis.
C40548	Topoisomerase_Interaction	Enzyme_Interaction	Topoisomerase Interaction	Topoisomerase Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction and spatial complementarity with enzymes that change the degree of supercoiling in DNA by cutting one or both strands. Type I topoisomerases cut only one strand of DNA, while type II topoisomerases cut both strands of DNA.
C40549	Tubulin_Interaction	Molecular_Interaction	Tubulin Binding|Tubulin Interaction	Tubulin Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction with highly conserved globular alpha, beta, or gamma tubulin protein subunits of microtubules.
C40550	Tumor_Necrosis_Factor_Receptor_Interaction	Cytokine_Receptor_Interaction	Tumor Necrosis Factor Receptor Binding	Tumor Necrosis Factor Receptor Binding involves a temporary non-covalent highly specific and high affinity interaction through intermolecular physical forces of attraction and spatial complementarity with a group of cell surface intrinsic membrane proteins (alpha and beta TNF Receptors, NGFR family) that mediate the cytotoxic effects of secreted glycoprotein cytokine TNF signaling molecules through modification of the activity of signal transduction pathways to regulate immune responses to infection.
C40551	Unknown_Cellular_or_Molecular_Interaction	Biophysical_Process	Unknown Cellular or Molecular Mechanism|Unknown Cellular or Molecular Interaction	An Unknown Cellular or Molecular Interaction consists of an activity or association of biologic molecules, complexes, or subcellular components that is currently undetermined.
C40552	CDK4_Gene_Inactivation	Gene_Abnormality	CDK4 Gene Inactivation
C40553	Tooth_and_Nail_Syndrome	Syndrome	Tooth and Nail Syndrome|Witkop Syndrome
C40554	MSX1_Gene_Mutation	Gene_Abnormality	MSX1 Gene Mutation
C40555	Composite_Lesion	Lesion	Composite Lesion
C40556	Morphologic_Overlap	Morphologic_Finding	Morphologic Overlap
C40557	Metastatic_Lesion	Lesion	Metastatic Lesion
C40558	Primary_Lesion	Lesion	Primary Lesion
C40559	Intraocular_Lesion	Lesion	Intraocular Lesion
C40560	Polypoid_Lesion	Lesion	Polypoid Lesion
C40561	Transformed_Phase_of_Disease	Clinical_Course_of_Disease	Transformed Phase of Disease
C40562	Transformed_Neoplastic_Lymphocyte	Neoplastic_Lymphocyte	Transformed Neoplastic Lymphocyte
C40563	Reactive_Plasma_Cell	Reactive_Lymphocyte	Reactive Plasma Cell
C40564	LOINC_Axis	Conceptual_Entities	LOINC Axis
C40565	Component_LOINC_Axis_1	LOINC_Axis	Component, LOINC Axis 1|Component|LOINC Axis 1	The name of the thing (chemical, protein, gene, cell, organ, antigen, event, action) that is being observed, assessed, detected, measured, counted, or evaluated.
C40566	Property_LOINC_Axis_2	LOINC_Axis	Property, LOINC Axis 2|LOINC Axis 2|Property	The type of characteristic that is being evaluated about the component.  For example, some kinds of properties are: mass, concentration, velocity, size, color, shape, duration, volume, count, and time of event.
C40567	Timing_LOINC_Axis_3	LOINC_Axis	Timing, LOINC Axis 3|LOINC Axis 3|Timing	The chronological relationship between when an observation is made and other relevant associated periods of time.  For example, the timing axis specifies whether a given observation represents the value of a measurement at a moment (point) in time, an average of the measurement over a period of time (24 hours, 72 hours, a nursing shift, a clinical encounter), a minimum or maximum over a period of time (24 hour maximum), or its ordinal rank within a period of time (first, second, last).
C40568	System_LOINC_Axis_4	LOINC_Axis	System, LOINC Axis 4|LOINC Axis 4|System	The physical environment (milieu, context) within which an observation is made.  For example, the system in which a sodium concentration is measured could be a urine sample, serum sample, or a plasma sample.
C40569	Scale_LOINC_Axis_5	LOINC_Axis	Scale, LOINC Axis 5|LOINC Axis 5|Scale	The metrological type (formal measurement type) of an observation. For example, some measurements are quantitative (the values for the measurement can be represented as solutions to an algebraic equation), ordinal (the values for the measurement can be placed in rank order), nominal (the values of the observation represent the names of the things that were seen), or narrative (the values of the observation are represented by free text expressions).
C40570	Method_LOINC_Axis_6	LOINC_Axis	Method, LOINC Axis 6|LOINC Axis 6|Method	The process by which an observation value was obtained.  Example methods include: weighing, use of a mass spectrometer, use of an ion sensitive electrode, and examination using a microscope.
C40571	REL_Gene_Amplification	Oncogene_Deregulation	REL Gene Amplification
C40574	Coagulation_Factor_Alteration	Biochemical_Process	Coagulation Factor Alteration	Coagulation Factor Alteration involves a change in the quality of the existing state of activity of endogenous substances, usually proteins, involved in the blood coagulation process. Alterations include increased or decreased production, activity, or degradation of coagulation factors.
C40575	DNA_Methylation_Inhibition	DNA_Methylation_Regulation	DNA Methylation Inhibition	DNA Methylation Inhibition involves interference with, or restraint of, the process by which methyl groups are added to genomic DNA nucleotides.
C40576	Enzyme_Activity_Alteration	Biochemical_Process	Enzyme Activity Alteration	Enzyme Activity Alteration involves a change in the quality of the existing state of function of a biological molecule (usually protein, RNA, or DNA) that possesses catalytic activity.
C40577	Enzyme_Inhibition	Enzyme_Activity_Alteration	Enzyme Inhibition	Enzyme Inhibition involves interference with, or restraint of, the function of a biological molecule (usually protein, RNA, or DNA) that possesses catalytic activity.
C40578	Enzyme_Reactivation	Enzyme_Activity_Alteration	Enzyme Reactivation	Enzyme Reactivation involves initiation of function, following prior inhibition, of a biological molecule (usually protein, RNA, or DNA) that possesses catalytic activity.
C40579	Growth_Factor_Inhibition	Intercellular_Signaling_Alteration	Growth Factor Inhibition	Growth Factor Inhibition involves interference with, or restraint of, the activities of extracellular signaling molecules (ligands) involved in the control of target cell proliferation, survival, and differentiation. Inhibition may involve interference with growth factor binding to receptors.
C40580	Histone_Deacetylation	Post-Translational_Modification	Histone Deacetylation	Histone Deacetylation is the covalent post-translational enzymatic addition of an acetyl group(s) to a histone protein. By exposing cationic sites on the protein that promote ionic interaction with the negatively charged DNA backbone, Histone Deacetylation induces DNA condensation and regulates genetic functions, such as transcription. (NCI)
C40582	Immunologic_Factor_Activation	Biochemical_Process	Immunologic Factor Activation	By decreased degradation, or increased production or receptor binding, Immunologic Factor Activation involves induction of the activity of antibody or cytokine proteins that affect immune functions, immune responses, or inflammation.
C40583	Antibody_Activation	Immunologic_Factor_Activation	Antibody Activation	Antibody Activation involves induction of the function of a class of cell-surface or secreted B lymphocyte proteins that non-covalently interact through intermolecular physical forces of attraction and spatial complementarity selectively and specifically with foreign substances (antigens), typically as part of an immune response. Activation mechanisms include decreased degradation or increased production and binding to antigen.
C40584	Cytokine_Activation	Immunologic_Factor_Activation	Cytokine Activation	Through decreased degradation, or increased production or receptor binding, Cytokine Activation involves induction of the activity of a class of soluble non-antibody paracrine or autocrine signaling glycoproteins (cytokines) secreted by immune cells that regulate immune responses through high affinity binding with specific receptors. Cytokines act as intercellular mediators regulating immune and inflammatory responses. Activation enhances cell proliferation and differentiation, secretion of other biologically active molecules, and responses to immune and inflammatory stimuli.
C40585	Colony_Stimulating_Factor_Activation	Cytokine_Activation	Colony Stimulating Factor Activation	Through decreased degradation, or increased production or receptor binding, Colony Stimulating Factor Activation involves induction of the activity of synergistic paracrine or autocrine glycoprotein growth factors (IL-3, G-CSF, M-CSF, and GM-CSF) that stimulate myeloid cell proliferation and differentiation of granulocyte and/or macrophage colonies.
C40586	Interferon_Activation	Cytokine_Activation	Interferon Activation	Through decreased degradation, or increased production or receptor binding, Interferon Activation involves induction of the activity of secreted proteins (alpha, beta, and gamma interferon types) that confer viral resistance, inhibit cell proliferation, enhance phagocytosis, augment NK cell activity, and show other immunomodulatory functions.
C40588	Interleukin_Activation	Cytokine_Activation	Interleukin Activation	Through decreased degradation, or increased production or receptor binding, Interleukin Activation involves induction of the activity of soluble cytokine factors with broad regulatory function (interleukins) produced by leukocytes and other cells that enhance leukocyte cell proliferation and differentiation, promote secretion of biologically active molecules, and regulate immune and inflammatory responses.
C40589	Tumor_Necrosis_Factor_Activation	Cytokine_Activation	Tumor Necrosis Factor Activation	By decreased degradation, or increased production or receptor binding, Tumor Necrosis Factor Activation involves induction of the activity of a family of cell surface or secreted cytotoxic glycoprotein cytokines (tumor necrosis factors) produced by activated leukocytes and involved in allergies, inflammation, lymphoid neogenesis, and lymphocyte homeostasis through stimulation of apoptosis.
C40592	Platelet_Activating_Factor_Activation	Immunologic_Factor_Activation	Platelet Activating Factor Activation	By decreased degradation, or increased production or receptor binding, Platelet Activating Factor Activation involves induction of the activity of a phospholipid derivative (platelet activating factor) formed by platelets, basophils, neutrophils, monocytes, and macrophages that acts as a potent agent of platelet aggregation, inflammation, neutrophil activity, prostaglandin synthesis, and systemic anaphylaxis: hypotension, thrombocytopenia, neutropenia, and bronchoconstriction.
C40593	Immunologic_Factor_Suppression	Biochemical_Process	Immunologic Factor Suppression	By increased degradation, or decreased production or receptor binding, Immunologic Factor Suppression involves interference with, or restraint of, the activities of antibody or cytokine proteins that affect immune functions, immune responses, or inflammation.
C40594	Antibody_Suppression	Immunologic_Factor_Suppression	Antibody Suppression	Antibody Suppression involves interference with, or restraint of, the activity of a class of cell-surface or secreted B lymphocyte proteins that non-covalently interact through intermolecular physical forces of attraction and spatial complementarity selectively and specifically with foreign substances (antigens), typically as part of an immune response. Suppression mechanisms include increased degradation or decreased production and binding to antigen.
C40595	Complement_Suppression	Immunologic_Factor_Suppression	Complement Suppression	By increased degradation, or by decreased production or activation, Complement Suppression consists of interference with, or restraint of, the activities of sequentially interacting serum proteins (some serine proteases), their receptors, and related regulatory proteins activated by cell-surface bound antibody, immune complexes, or a microbial membrane carbohydrate and involved in complex cascades (classical or properdin pathway) that generate Membrane Attack Complex, which creates target cell wall pores and lysis. The complement system also plays a role in antibody-dependent cytolysis, anaphylaxis, phagocytosis, opsonization, chemotaxis, and hemolysis.
C40596	Cytokine_Suppression	Immunologic_Factor_Suppression	Cytokine Suppression	Through increased degradation, or decreased production or receptor binding, Cytokine Suppression involves interference with, or restraint of, the activity of a class of soluble non-antibody paracrine or autocrine signaling glycoproteins (cytokines) secreted by immune cells that regulate immune responses through high affinity binding with specific receptors. Cytokines act as intercellular mediators regulating immune and inflammatory responses. Suppression decreases cell proliferation and differentiation, secretion of other biologically active molecules, and responses to immune and inflammatory stimuli.
C40597	Colony_Stimulating_Factor_Suppression	Cytokine_Suppression	Colony Stimulating Factor Suppression	Through increased degradation, or decreased production or receptor binding, Colony Stimulating Factor Suppression involves interference with, or restraint of, the activities of synergistic paracrine or autocrine glycoprotein growth factors (IL-3, G-CSF, M-CSF, and GM-CSF) that stimulate myeloid cell proliferation and differentiation of granulocyte and/or macrophage colonies.
C40598	Interferon_Suppression	Cytokine_Suppression	Interferon Suppression	Through increased degradation, or decreased production or receptor binding, Interferon Suppression involves interference with, or restraint of, the activities of secreted proteins (alpha, beta, and gamma interferon types) that confer viral resistance, inhibit cell proliferation, enhance phagocytosis, augment NK cell activity, and show other immunomodulatory functions.
C40599	Interleukin_Suppression	Cytokine_Suppression	Interleukin Suppression	Through increased degradation, or decreased production or receptor binding, Interleukin Suppression involves interference with, or restraint of, the activities of soluble cytokine factors with broad regulatory function (interleukins) produced by leukocytes and other cells that enhance leukocyte cell proliferation and differentiation, promote secretion of biologically active molecules, and regulate immune and inflammatory responses.
C40601	Tumor_Necrosis_Factor_Suppression	Cytokine_Suppression	Tumor Necrosis Factor Suppression	By increased degradation, or decreased production or receptor binding, Tumor Necrosis Factor Suppression involves interference with, or restraint of, the activities of a family of cell surface or secreted cytotoxic glycoprotein cytokines (tumor necrosis factors) produced by activated leukocytes and involved in allergies, inflammation, lymphoid neogenesis, and lymphocyte homeostasis through stimulation of apoptosis.
C40604	Platelet_Activating_Factor_Suppression	Immunologic_Factor_Suppression	Platelet Activating Factor Suppression	By increased degradation, or decreased production or receptor binding, Platelet Activating Factor Suppression involves interference with, or restraint of, the activity of a phospholipid derivative (platelet activating factor) formed by platelets, basophils, neutrophils, monocytes, and macrophages that acts as a potent agent of platelet aggregation, inflammation, neutrophil activity, prostaglandin synthesis, and systemic anaphylaxis: hypotension, thrombocytopenia, neutropenia, and bronchoconstriction.
C40613	Placental_Hormone_Activity_Alteration	Intercellular_Signaling_Alteration	Placental Hormone Activity Alteration	By increased or decreased production, release, or degradation, Placental Hormone Activity Alteration involves a change in the quality of the existing state of activity of hormones secreted by the placenta. Influencing ovarian, uterine, mammary, and fetal physiology, placental hormones include progestins, estrogens, relaxin, and placental lactogens.
C40614	Prolactin_Inhibiting_Factor_Activity_Alteration	Intercellular_Signaling_Alteration	Prolactin Inhibiting Factor Activity Alteration	By increased or decreased production, release, or degradation, Prolactin Inhibiting Factor Activity Alteration involves a change in the quality of the existing state of activity of Prolactin Inhibiting Factor. Such alterations result in increased or decreased release of prolactin.
C40615	Prolactin_Releasing_Factor_Activity_Alteration	Intercellular_Signaling_Alteration	Prolactin Releasing Factor Activity Alteration	By increased or decreased production, release, or degradation, Prolactin Releasing Factor Activity Alteration involves a change in the quality of the existing state of activity of Prolactin Releasing Factor. Such alterations result in increased or decreased release of prolactin.
C40616	Renal_Hormone_Activity_Alteration	Intercellular_Signaling_Alteration	Renal Hormone Activity Alteration	By increased or decreased production, release, or degradation, Renal Hormone Activity Alteration involves a change in the quality of the existing state of activity of hormones secreted by the kidney. Alterations in renal erythropoietin increase or decrease red blood cell production.
C40624	Amino_Acid_Synthesis_Inhibition	Amino_Acid-Peptide-Protein_Metabolism	Amino Acid Synthesis Inhibition	Amino Acid Synthesis Inhibition involves interference with, or restraint of, enzymatic formation of organic compounds that contain an amino (-NH2) and a carboxyl (-COOH) group.
C40625	Biogenic_Amine_Metabolism	Metabolic_Process	Biogenic Amine Metabolism	Biogenic Amine Metabolism involves anabolic and catabolic biochemical changes to a type of nitrogen containing hydrocarbons (biogenic amines) involved in signaling as neurotransmitters or hormones or as components of vitamins, phospholipids, or ribosomes within a cell as materials needed for important life processes.
C40626	Histamine_Degradation	Biogenic_Amine_Metabolism	Histamine Degradation	Histamine Degradation consists of conjugation, transport, oxidation, or enzymatic breakdown of a decarboxylation product of histidine (histamine), found particularly in mast cells and basophils, and involved in capillary dilation and permeability; blood pressure decrease; smooth muscle contraction; gastric secretion; heart rate acceleration; immediate hypersensitivity; and central neurotransmission.
C40627	Histamine_Production	Biogenic_Amine_Metabolism	Histamine Production	Histamine Production consists of synthesis of a decarboxylation product of histidine (histamine), found particularly in mast cells and basophils, and involved in capillary dilation and permeability; blood pressure decrease; smooth muscle contraction; gastric secretion; heart rate acceleration; immediate hypersensitivity; and central neurotransmission.
C40628	Serotonin_Degradation	Biogenic_Amine_Metabolism	Serotonin Degradation	By induction of conjugation, transport, and/or oxidation, Serotonin Degradation consists of breakdown of a secreted biochemical messenger and regulator (serotonin) synthesized from L-Tryptophan that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity through multiple receptor families on specific target cells.
C40629	Serotonin_Production	Biogenic_Amine_Metabolism	Serotonin Production	Serotonin Production consists of synthesis from L-Tryptophan of a secreted biochemical messenger and regulator (serotonin) that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity through multiple receptor families on specific target cells.
C40630	Carbohydrate_Metabolism_Alteration	Carbohydrate_Metabolism	Carbohydrate Metabolism Alteration	Carbohydrate Metabolism Alteration involves a change in the quality of the existing state of cellular oxidation, breakdown, and synthesis of carbohydrates.
C40632	Gluconeogenesis_Induction	Carbohydrate_Metabolism_Alteration	Gluconeogenesis Induction	Gluconeogenesis Induction involves initiation of the biosynthesis of glucose from 3-carbon non-carbohydrate precursors, including amino acids (the basis of protein breakdown during starvation).
C40633	Gluconeogenesis_Inhibition	Carbohydrate_Metabolism_Alteration	Gluconeogenesis Inhibition	Gluconeogenesis Inhibition involves interference with, or restraint of, the biosynthesis of glucose from 3-carbon non-carbohydrate precursors, including amino acids (the basis of protein breakdown during starvation).
C40634	Glycolysis_Induction	Carbohydrate_Metabolism_Alteration	Glycolysis Induction	Glycolysis Induction involves initiation of activities of the pathway by which glucose is catabolized into two molecules of pyruvic acid with the generation of ATP.
C40635	Glycolysis_Inhibition	Carbohydrate_Metabolism_Alteration	Glycolysis Inhibition	Glycolysis Inhibition involves interference with, or restraint of, the activities of the pathway by which glucose is catabolized into two molecules of pyruvic acid with the generation of ATP.
C40637	Glycogenesis_Induction	Carbohydrate_Metabolism_Alteration	Glycogenesis Induction	Glycogenesis Induction consists of initiation of activities of biologic molecules or complexes involved in the formation of glycogen from glucose.
C40638	Glycogenesis_Inhibition	Carbohydrate_Metabolism_Alteration	Glycogenesis Inhibition	Glycogenesis Inhibition consists of interference with, or restraint of, the activities of biologic molecules or complexes involved in the formation of glycogen from glucose.
C40639	Glycogenolysis_Induction	Carbohydrate_Metabolism_Alteration	Glycogenolysis Induction	Glycogenolysis Induction involves initiation of activities of biologic molecules or complexes involved in the breakdown of glycogen to glucose by hydrolysis or phosphorolysis. Glycogen is released in response to low blood glucose and epinephrine release.
C40640	Glycogenolysis_Inhibition	Carbohydrate_Metabolism_Alteration	Glycogenolysis Inhibition	Glycogenolysis Inhibition involves interference with, or restraint of, the activities of biologic molecules or complexes involved in the breakdown of glycogen to glucose by hydrolysis or phosphorolysis. Glycogen is released in response to low blood glucose and epinephrine release.
C40641	Carbohydrate_Processing_Inhibition	Metabolic_Process	Carbohydrate Processing Inhibition	Carbohydrate Processing Inhibition consists of interference with, or restraint of, activities involved in assembly of carbohydrate-linked structures on cell surfaces, such as inhibition of enzymes responsible for the formation of these structures.  Since evidence indicates that carbohydrate structures are involved in intercellular communication, inhibition potentially results in decreased cancer cell growth, invasiveness, and metastasis.
C40642	Estrogen_Metabolism_Alteration	Estrogen_Metabolism	Estrogen Metabolism Alteration	Estrogen Metabolism Alteration involves a change in the quality of the existing state of diverse biochemical reactions primarily in the ovary that produce 19-carbon steroid hormones, which promote secondary female sexual development and menstrual function or convert such steroids to metabolic derivatives.
C40643	Folic_Acid_Metabolism_Inhibition	Folate_Metabolism	Folic Acid Metabolism Inhibition	Folic Acid Metabolism Inhibition involves interference with, or restraint of, the activities of enzymatic biotransforming chemical modifications of folic acid.
C40644	Gene_Expression_Alteration	Gene_Expression_Process	Gene Expression Alteration	Gene Expression Alteration involves a change in the quality of the existing state of transcription of genetically encoded information into an intermediary message (messenger RNA) and subsequent translation into a functional protein. (NCI)
C40645	Lipid_Metabolism	Lipid-Lipoprotein-Membrane_Constituent_Metabolism	Lipid Metabolism	Lipid Metabolism involves anabolic and catabolic biochemical changes to the hydrophobic class of biochemicals within a cell as materials needed for important life processes.
C40646	Cholesterol_Synthesis_Inhibition	Lipid_Metabolism	Cholesterol Synthesis Inhibition	Cholesterol Synthesis Inhibition involves interference with, or restraint of, the enzymatic formation of the principal sterol of vertebrates in body tissues and blood plasma, an important component of cell membranes, the major precursor for the synthesis of vitamin D and steroid hormones, and an important substance for brain synapses and immune functions.
C40647	Eicosanoid_Modulation	Lipid_Metabolism	Eicosanoid Modulation	Eicosanoid Modulation involves a change in the quality of the existing state of activity of hormone-like endogenous unsaturated and oxygenated fatty acid derivatives of arachidonic acid (eicosanoids) that act near the site of synthesis and have a specific regulatory effect on the activity of target cells in host defense reactions, immediate hypersensitivity, and inflammation. Eicosanoids include prostaglandins, leukotrienes, thromboxanes, and hydroxyeicosatetraenoic acid compounds.
C40648	Eicosanoid_Degradation	Eicosanoid_Modulation	Eicosanoid Degradation	Eicosanoid Degradation consists of conjugation, transport, and/or oxidation of hormone-like endogenous unsaturated and oxygenated fatty acid derivatives of arachidonic acid (eicosanoids) that act near the site of synthesis and have a specific regulatory effect on the activity of target cells in host defense reactions, immediate hypersensitivity, and inflammation. Eicosanoids include prostaglandins, leukotrienes, thromboxanes, and hydroxyeicosatetraenoic acid compounds.
C40649	Leukotriene_Degradation	Eicosanoid_Degradation	Leukotriene Degradation	Leukotriene Degradation consists of conjugation, transport, and/or oxidation of a family of oxidative derivatives of arachidonic acid (5-lipoxygenase pathway) (leukotrienes) having potent regulatory effects on the activity of cardiovascular, pulmonary, central neural, gastrointestinal, and immune system cells involved in host defense, immediate hypersensitivity, and inflammation.
C40650	Prostaglandin_Degradation	Eicosanoid_Degradation	Prostaglandin Degradation	Prostaglandin Degradation consists of conjugation, transport, and/or oxidation of compounds derived primarily from arachidonic acid (cyclooxygenase pathway) (prostaglandins) having potent regulatory effects on the activity of cells involved in host defense and inflammation.
C40651	Thromboxane_Degradation	Eicosanoid_Degradation	Thromboxane Degradation	Thromboxane Degradation consists of conjugation, transport, and/or oxidation of widely distributed compounds formed by cyclooxygenase from polyunsaturated fatty acid prostaglandin endoperoxides (thromboxanes) and have a regulatory effect on platelet aggregation, contraction of arteries, and other biological effects.
C40652	Eicosanoid_Production	Eicosanoid_Modulation	Eicosanoid Production	Eicosanoid Production consists of synthesis of hormone-like endogenous unsaturated and oxygenated fatty acid derivatives of arachidonic acid (eicosanoids) that act near the site of synthesis and have a specific regulatory effect on the activity of target cells in host defense reactions, immediate hypersensitivity, and inflammation. Eicosanoids include prostaglandins, leukotrienes, thromboxanes, and hydroxyeicosatetraenoic acid compounds.
C40653	Leukotriene_Production	Eicosanoid_Production	Leukotriene Production	Leukotriene Production consists of synthesis of a family of oxidative derivatives of arachidonic acid (5-lipoxygenase pathway) (leukotrienes) having potent regulatory effects on the activity of cardiovascular, pulmonary, central neural, gastrointestinal, and immune system cells involved in host defense, immediate hypersensitivity, and inflammation.
C40654	Prostaglandin_Production	Eicosanoid_Production	Prostaglandin Production	Prostaglandin Production consists of synthesis of compounds derived primarily from arachidonic acid (cyclooxygenase pathway) (prostaglandins) having potent regulatory effects on the activity of cells involved in host defense and inflammation.
C40655	Thromboxane_Production	Eicosanoid_Production	Thromboxane Production	Thromboxane Production consists of synthesis of widely distributed compounds formed by cyclooxygenase from polyunsaturated fatty acid prostaglandin endoperoxides (thromboxanes) and have a regulatory effect on platelet aggregation, contraction of arteries, and other biological effects.
C40656	Phospholipid_Metabolism	Lipid_Metabolism	Phospholipid Metabolism	Phospholipid Metabolism involves anabolic and catabolic biochemical changes made to the heterogeneous class of phosphate derivative hydrophobic aliphatic hydrocarbons within a cell needed for important life processes and a major form of lipid in all cell membranes.
C40657	Triglyceride_Metabolism	Lipid_Metabolism	Triglyceride Metabolism	Triglyceride Metabolism involves anabolic and catabolic biochemical changes to the hydrophobic class of biochemicals within a cell composed of three fatty acid chains linked to a glycerol molecule as materials needed for important life processes.
C40658	Nucleic_Acid_Synthesis_Alteration	Nucleotide_Metabolism	Nucleic Acid Synthesis Alteration	Nucleic Acid Synthesis Alteration involves a change in the quality of the existing cellular state of polymeric linkage of ribose or deoxyribose purine and pyrimidine nucleotides together by phosphate groups attached to their 5-prime and 3-prime sugar hydroxyls.
C40661	DNA_Repair_Inhibition	DNA_Maintenance_Process	DNA Repair Inhibition	DNA Repair Inhibition involves interference with, or restraint of, the enzymatic restoration of a continuous two-stranded DNA molecule without mismatch from a molecule that contains regions damaged by chemical or radiation exposure or by spontaneous damage. The major repair mechanisms are photoreactivation repair, excision repair, and post-replication repair.
C40662	Nucleotide_Excision_Repair_Inhibition	DNA_Repair_Inhibition	Nucleotide Excision Repair Inhibition	Nucleotide Excision Repair (NER) Inhibition involves interference with, or restraint of, the activities that mend DNA regions containing chemical adducts, carcinogenic adducts, or thymine dimers. During NER in eukaryotes, protein complexes detect DNA shape irregularities, induce cuts on each side of the lesion, remove the damaged fragment, and repair the helix by synthesis and ligation.
C40663	DNA_Synthesis_Induction	Nucleic_Acid_Synthesis_Alteration	DNA Synthesis Induction	DNA Synthesis Induction consists of the initiation of activities involved in the polymeric linkage of deoxyribose moieties (with adenine, guanine, cytosine, or thymine side chains) by phosphate groups attached to their 5-prime and 3-prime sugar hydroxyls.
C40664	DNA_Synthesis_Inhibition	Nucleic_Acid_Synthesis_Alteration	DNA Synthesis Inhibition	DNA Synthesis Inhibition involves interference with, or restraint of, the activities involved in the polymeric linkage of deoxyribose moieties (with adenine, guanine, cytosine, or thymine side chains) by phosphate groups attached to their 5-prime and 3-prime sugar hydroxyls.
C40666	RNA_Synthesis_Induction	Nucleic_Acid_Synthesis_Alteration	RNA Synthesis Induction	RNA Synthesis Induction consists of the initiation of activities involved in the polymeric linkage of ribose purine and pyrimidine nucleotides together by phosphate groups attached to their 5-prime and 3-prime sugar hydroxyls.
C40667	RNA_Synthesis_Inhibition	Nucleic_Acid_Synthesis_Alteration	RNA Synthesis Inhibition	RNA Synthesis Inhibition involves interference with, or restraint of, the activities involved in the polymeric linkage of ribose purine and pyrimidine nucleotides together by phosphate groups attached to their 5-prime and 3-prime sugar hydroxyls.
C40668	Nucleotide_Synthesis_Alteration	Nucleotide_Metabolism_Alteration	Nucleotide Synthesis Alteration	Nucleotide Synthesis Alteration involves a change in the quality of the existing state of activities of biologic molecules or complexes involved in the enzymatic formation of nucleoside phosphates, the monomeric building blocks from which DNA or RNA polymers are constructed that consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group.
C40669	Purine_Synthesis_Inhibition	Nucleotide_Synthesis_Inhibition	Purine Synthesis Inhibition	Purine Synthesis Inhibition involves interference with, or restraint of, the activities of biologic molecules or complexes involved in the enzymatic formation of purine nucleoside phosphates, monomeric building blocks from which DNA or RNA polymers are constructed that consist of a purine base, a pentose sugar, and a phosphate group.
C40670	Pyrimidine_Synthesis_Inhibition	Nucleotide_Synthesis_Inhibition	Pyrimidine Synthesis Inhibition	Pyrimidine Synthesis Inhibition involves interference with, or restraint of, the activities of biologic molecules or complexes involved in the enzymatic formation of pyrimidine nucleoside phosphates, monomeric building blocks from which DNA or RNA polymers are constructed that consist of a pyrimidine base, a pentose sugar, and a phosphate group.
C40671	Polyamine_Synthesis_Inhibition	Intermediary_Metabolism	Polyamine Synthesis Inhibition	Polyamine Synthesis Inhibition involves interference with, or restraint of, the activities of biologic molecules or complexes involved in the enzymatic formation of low molecular weight organic cations containing two or more amine groups (polyamines).
C40673	Protein_Degradation_Induction	Amino_Acid-Peptide-Protein_Metabolism	Protein Degradation Induction	Protein Degradation Induction involves initiation of specific degradation of a protein - involving conjugation, transport, oxidation, and proteolysis. Often involved in signal transduction or cell communication events, protein degradation is not to be confused with proteolysis, which applies only to peptide bond hydrolysis. (NCI)
C40674	Adhesion_Factor_Degradation	Protein_Degradation_Induction	Adhesion Factor Degradation	By induction of conjugation, transport, oxidation, and/or proteolysis, Adhesion Factor Degradation consists of breakdown of members of the class of cell surface proteins involved in cell-cell or cell-matrix attachment.
C40676	Antibody_Degradation	Protein_Degradation_Induction	Antibody Degradation	Antibody Degradation consists of conjugation, transport, oxidation, and/or proteolysis of members of a class of cell-surface or secreted B lymphocyte proteins that non-covalently interact through intermolecular physical forces of attraction and spatial complementarity selectively and specifically with foreign substances (antigens), typically as part of an immune response.
C40677	Complement_Degradation	Protein_Degradation_Induction	Complement Degradation	Complement Degradation consists of conjugation, transport, oxidation, and/or proteolysis of complement system proteins; sequentially interacting serum proteins (some serine proteases), their receptors, and related regulatory proteins. Activated by cell-surface bound antibody, immune complexes, or a microbial membrane carbohydrate, complex complement cascades (classical or properdin pathway) generate Membrane Attack Complex, which creates target cell wall pores and lysis. The complement system also plays a role in antibody-dependent cytolysis, anaphylaxis, phagocytosis, opsonization, chemotaxis, and hemolysis.
C40678	Cytokine_Degradation	Protein_Degradation_Induction	Cytokine Degradation	Cytokine Degradation consists of conjugation, transport, oxidation, and/or proteolysis of a class of soluble non-antibody paracrine or autocrine signaling glycoproteins (cytokines) secreted by immune cells that regulate immune responses through high affinity binding with specific receptors. Cytokines act as intercellular mediators regulating immune and inflammatory responses. Activation enhances cell proliferation and differentiation, secretion of other biologically active molecules, and responses to immune and inflammatory stimuli.
C40679	Platelet_Activating_Factor_Degradation	Phospholipid_Metabolism	Platelet Activating Factor Degradation	Platelet Activating Factor Degradation consists of conjugation, transport, and/or oxidation of a phospholipid derivative (platelet activating factor) formed by platelets, basophils, neutrophils, monocytes, and macrophages that acts as a potent agent of platelet aggregation, inflammation, neutrophil activity, prostaglandin synthesis, and systemic anaphylaxis: hypotension, thrombocytopenia, neutropenia, and bronchoconstriction.
C40680	Protein_Degradation_Inhibition	Amino_Acid-Peptide-Protein_Metabolism	Protein Degradation Inhibition	Protein Degradation Inhibition involves interference with, or restraint of, specific degradation of a protein - involving conjugation, transport, oxidation, and proteolysis. Often involved in signal transduction or cell communication events, protein degradation is not to be confused with proteolysis, which applies only to peptide bond hydrolysis. (NCI)
C40681	Adhesion_Factor_Stabilization	Protein_Degradation_Inhibition	Adhesion Factor Stabilization	Adhesion Factor Stabilization inhibits conjugation, transport, oxidation, or proteolysis of cell surface proteins involved in cell-cell or cell-matrix attachment. Such stabilization can alter maintenance of tissue integration, wound healing, cellular migrations, and metastasis.
C40683	Antibody_Stabilization	Protein_Degradation_Inhibition	Antibody Stabilization	Antibody Stabilization inhibits conjugation, transport, oxidation, or proteolysis of a class of cell-surface or secreted B lymphocyte proteins that non-covalently interact through intermolecular physical forces of attraction and spatial complementarity selectively and specifically with foreign substances (antigens), typically as part of an immune response.
C40684	Complement_Stabilization	Protein_Degradation_Inhibition	Complement Stabilization	Complement Stabilization inhibits conjugation, transport, oxidation, or proteolysis of complement system proteins; sequentially interacting serum proteins (some serine proteases), their receptors, and related regulatory proteins. Activated by cell-surface bound antibody, immune complexes, or a microbial membrane carbohydrate, complex complement cascades (classical or properdin pathway) generate Membrane Attack Complex, which creates target cell wall pores and lysis. The complement system also plays a role in antibody-dependent cytolysis, anaphylaxis, phagocytosis, opsonization, chemotaxis, and hemolysis.
C40685	Cytokine_Stabilization	Protein_Degradation_Inhibition	Cytokine Stabilization	Cytokine Stabilization inhibits conjugation, transport, oxidation, or proteolysis of a class of soluble non-antibody paracrine or autocrine signaling glycoproteins (cytokines) secreted by immune cells that regulate immune responses through high affinity binding with specific receptors. Cytokines act as intercellular mediators regulating immune and inflammatory responses. Activation enhances cell proliferation and differentiation, secretion of other biologically active molecules, and responses to immune and inflammatory stimuli.
C40686	Platelet_Activating_Factor_Stabilization	Phospholipid_Metabolism	Platelet Activating Factor Stabilization	Platelet Activating Factor Stabilization inhibits conjugation, transport, oxidation, or proteolysis of a phospholipid derivative (platelet activating factor) formed by platelets, basophils, neutrophils, monocytes, and macrophages that acts as a potent agent of platelet aggregation, inflammation, neutrophil activity, prostaglandin synthesis, and systemic anaphylaxis: hypotension, thrombocytopenia, neutropenia, and bronchoconstriction.
C40687	Thyroid_Hormone_Iodination_Alteration	Metabolic_Process	Thyroid Hormone Iodination Alteration|Thyroid Hormone Organification Alteration	Thyroid Hormone Iodination Alteration involves a change in the quality of the existing state of incorporation of iodine into T3 (triiodothyronine) and T4 (thyroxine) hormones secreted by the thyroid gland after conversion from thyroglobulin.
C40688	Thyroid_Hormone_Organification_Alteration	Retired_Concepts	Thyroid Hormone Organification Alteration
C40689	Transcription_Alteration	Transcription_Process	Transcription Alteration	Transcription Alteration involves a change in the quality of the existing state of the cellular process in which genetic information is transferred from DNA to messenger RNA by DNA-directed RNA polymerase.
C40690	Reverse_Transcription_Induction	Replication-Associated_Process	Reverse Transcription Induction	Reverse Transcription Induction involves initiation of activities involved in copying RNA into DNA by reverse transcriptase.
C40691	Reverse_Transcription_Inhibition	Replication-Associated_Process	Reverse Transcription Inhibition	Reverse Transcription Inhibition involves interference with, or restraint of, activities involved in copying RNA into DNA by reverse transcriptase.
C40692	RNA_Transcription_Inhibition	Transcription_Alteration	RNA Transcription Inhibition	RNA Transcription Inhibition involves interference with, or restraint of, the activities of the cellular process in which genetic information is transferred from DNA to messenger RNA by DNA-directed RNA polymerase.
C40693	Translation_Alteration	Translation_Process	Translation Alteration	Translation Alteration involves a change in the quality of the existing state of the cellular process at the ribosome whereby the information in mRNA is used to specify the sequence of amino acids in a polypeptide chain.
C40694	Protein_Synthesis_Induction	Translation_Alteration	Protein Synthesis Induction	Protein Synthesis Induction involves initiation of the activities of the chemical process by which polypeptide chains are synthesized.
C40695	Adhesion_Factor_Production	Biosynthesis	Adhesion Factor Production	Adhesion Factor Production consists of synthesis of cell surface proteins involved in cell-cell or cell-matrix attachment. Such synthesis can alter maintenance of tissue integration, wound healing, cellular migrations, and metastasis.
C40697	Protein_Synthesis_Inhibition	Translation_Alteration	Protein Synthesis Inhibition	Protein Synthesis Inhibition involves interference with, or restraint of, the activities of the chemical process by which polypeptide chains are synthesized.
C40698	Adhesion_Factor_Suppression	Metabolic_Process	Adhesion Factor Suppression	By decreased production or increased degradation, Adhesion Factor Suppression consists of interference with, or restraint of, the expression or activity of cell surface proteins involved in cell-cell or cell-matrix attachment. Such suppression alters maintenance of tissue integration, wound healing, cellular migrations, and metastasis.
C40699	Uric_Acid_Synthesis_Inhibition	Intermediary_Metabolism	Uric Acid Synthesis Inhibition	Uric Acid Synthesis Inhibition involves interference with, or restraint of, the formation of the water-insoluble end-product of purine catabolism in primates.
C40700	Molecular_Marker_Activity	Biochemical_Process	Molecular Marker Activity	Molecular Marker Activity involves temporary non-covalent interaction through intermolecular physical forces of attraction and spatial complementarity with a substance, such as a cell surface antigen, that assists in antigen localization or evaluation of cellular activity.
C40702	Receptor_Activation	Cell_Signaling_Process	Receptor Activation	Receptor Activation typically involves a high-affinity binding interaction of a signaling molecule (ligand) with a specific target protein causing a conformational and functional change in the receptor molecule. Altered interaction of the ligand-bound receptor with target molecules leads in turn to changes in cellular physiology through modification of the activity of one or more signal transduction pathways.
C40703	Receptor_Inhibition	Protein_Inhibition	Receptor Inhibition|Receptor Inactivation	Receptor Inhibition typically involves an interference with, or restraint of, the activity of any member of a diverse group of membrane or cytoplasmic proteins that regulate the activity of signal transduction pathways and cellular physiology in response to regulatory signaling molecules.
C40704	Tyrosine_Kinase_Receptor_Inhibition	Receptor_Inhibition	Tyrosine Kinase Receptor Inhibition	Tyrosine Kinase Receptor Inhibition involves interference with, or restraint of, the activity of cellular receptors for mitogenic and cell differentiation factors that have an intrinsic protein-tyrosine kinase activity integral to receptor function as a signal transducer; phosphorylation alters the function of the receptor's protein substrate(s).
C40708	Cell_Adhesion_Inhibition	Cell_Adhesion_Process	Cell Adhesion Inhibition	Cell Adhesion Inhibition involves interference with, or restraint of, the activities of biologic molecules, biologic complexes, or subcellular components that promote the adherence of cells to surfaces or to other cells.
C40709	Cell-Cell_Adhesion_Inhibition	Cell_Adhesion_Inhibition	Cell-Cell Adhesion Inhibition	Cell-Cell Adhesion Inhibition involves interference with, or restraint of, the activities of biologic molecules, biologic complexes, or subcellular components that promote the adherence of cells to other cells.
C40710	Cell-Matrix_Adhesion_Inhibition	Cell_Adhesion_Inhibition	Cell-Matrix Adhesion Inhibition	Cell-Matrix Adhesion Inhibition involves interference with, or restraint of, the activities of biologic molecules, biologic complexes, or subcellular components that promote the adherence of cells to the extracellular matrix.
C40711	Platelet_Aggregation_Alteration	Multicellular_Process	Platelet Aggregation Alteration	Platelet Aggregation Alteration involves a change in the quality of the existing state of platelet attachment to one another. Platelet Aggregation can be affected by a number of agents as part of the mechanism regulating to the formation of a thrombus.
C40712	Platelet_Aggregation_Induction	Platelet_Aggregation_Alteration	Platelet Aggregation Induction	Platelet Aggregation Induction involves initiation of activities of biologic molecules or complexes involved in the attachment of platelets to one another. Induced by a number of agents (e.g., thrombin, collagen), platelet aggregation is part of the mechanism leading to the formation of a thrombus.
C40713	Platelet_Aggregation_Inhibition	Platelet_Aggregation_Alteration	Platelet Aggregation Inhibition	Platelet Aggregation Inhibition involves interference with, or restraint of, the activities of biologic molecules or complexes involved in the attachment of platelets to one another. Platelet Aggregation can be affected by a number of agents as part of the mechanism regulating to the formation of a thrombus.
C40715	Cell_Death_Induction	Cell_Death_Process	Cell Death Induction	Cell Death Induction involves initiation of activities of biologic molecules, biologic complexes, or subcellular components within a cell or among cells that lead to the termination of a cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
C40716	Immune_Cell_Destruction_Induction	Cell_Death_Induction	Immune Cell Destruction Induction	Immune Cell Destruction Induction involves initiation of activities that result in elimination of one or more lymphoid or myeloid cell types associated with the immune response.
C40717	Lymphocyte_Destruction_Induction	Immune_Cell_Destruction_Induction	Lymphocyte Destruction Induction	Lymphocyte Destruction Induction involves initiation of activities that result in elimination of white blood cells formed in lymphoid tissue and generally classified as T- or B-cells. T-lymphocytes provide cell-mediated immunity, while B-lymphocytes produce antibodies that provide humoral immunity.  Stimulation increases the immune response to invading substances.
C40720	Myeloid_Cell_Destruction_Induction	Immune_Cell_Destruction_Induction	Myeloid Cell Destruction Induction	Myeloid Cell Destruction Induction involves initiation of activities that result in elimination of leukocytes formed in the bone marrow, such as monocytes and granulocytes, that protect the body against foreign substances by ingesting or phagocytizing them.
C40724	Cytolysis_Induction	Cell_Death_Induction	Cytolysis Induction	Cytolysis Induction involves initiation of cell membrane rupture, loss of cytoplasm, and dissolution or destruction of cells.
C40725	Hemolysis_Induction	Cytolysis_Induction	Hemolysis Induction	Hemolysis Induction involves initiation of disruption of the red blood cell membrane causing release of hemoglobin.
C40726	Necrosis_Induction	Cell_Death_Induction	Necrosis Induction	Necrosis Induction involves initiation of pathologic, localized and unprogrammed cell death caused by the progressive action of degradative enzymes. Generally associated with severe cellular trauma, necrosis is characterized by mitochondrial swelling, nuclear flocculation, cell lysis, and cell death. (NCI)
C40727	Cell_Death_Inhibition	Cell_Death_Process	Cell Death Inhibition	Cell Death Inhibition involves interference with, or restraint of, the activities of biologic molecules, biologic complexes, or subcellular components within a cell or among cells that lead to the termination of a cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
C40728	Immune_Cell_Destruction_Inhibition	Cell_Death_Inhibition	Immune Cell Destruction Inhibition	Immune Cell Destruction Inhibition involves interference with, or restraint of, activities that result in elimination of one or more lymphoid or myeloid cell types associated with the immune response.
C40729	Lymphocyte_Destruction_Inhibition	Immune_Cell_Destruction_Inhibition	Lymphocyte Destruction Inhibition	Lymphocyte Destruction Inhibition involves interference with, or restraint of, activities that result in elimination of white blood cells formed in lymphoid tissue and generally classified as T- or B-cells. T-lymphocytes provide cell-mediated immunity, while B-lymphocytes produce antibodies that provide humoral immunity.  Stimulation increases the immune response to invading substances.
C40732	Myeloid_Cell_Destruction_Inhibition	Immune_Cell_Destruction_Inhibition	Myeloid Cell Destruction Inhibition	Myeloid Cell Destruction Inhibition involves interference with, or restraint of, activities that result in elimination of leukocytes, formed in the bone marrow (monocytes and granulocytes), that protect the body against foreign substances by ingesting or phagocytizing them.
C40736	Hemolysis_Inhibition	Cytolysis_Inhibition	Hemolysis Inhibition	Hemolysis Inhibition involves interference with, or restraint of, disruption of the red blood cell membrane.
C40738	Cell_Differentiation_Induction	Cell_Differentiation_Process	Cell Differentiation Induction	Cell Differentiation Induction involves initiation of progressive and normally irreversible processes whereby restriction of the developmental potential of immature precursor cells results in increasing specialization of cell function and morphology.
C40739	Hematopoiesis_Induction	Cell_Differentiation_Induction	Hematopoiesis Induction	Hematopoiesis Induction involves initiation of a process of blood formation; more specifically formation of blood cells that are all derived from hematopoietic stem cells.
C40740	Cell_Differentiation_Inhibition	Cell_Differentiation_Process	Cell Differentiation Inhibition	Cell Differentiation Inhibition involves interference or restraint of progressive and normally irreversible processes whereby restriction of the developmental potential of immature precursor cells results in increasing specialization of cell function and morphology.
C40741	Hematopoiesis_Inhibition	Cell_Differentiation_Inhibition	Hematopoiesis Inhibition	Hematopoiesis Inhibition involves interference or restraint of a process of blood formation; more specifically formation of blood cells that are all derived from hematopoietic stem cells.
C40742	Cell_Migration_Alteration	Cell_Movement_Process	Cell Migration Alteration	Cell Migration Alteration involves a change in the quality of the existing state of a cell regarding active translocation of the whole cell, or cell body, from one site to another in response to a gradient. (NCI)
C40743	Cell_Migration_Induction	Cell_Migration_Alteration	Cell Migration Induction	Cell Migration Induction involves initiation of active directed translocation of a whole cell, or cell body, from one site to another in response to a gradient. (NCI)
C40746	Cell_Migration_Inhibition	Cell_Migration_Alteration	Cell Migration Inhibition	Cell Migration Inhibition involves interference with, or restraint of, active directed translocation of a whole cell, or cell body, from one site to another in response to a gradient. (NCI)
C40751	Chemotaxis_Induction	Cell_Migration_Induction	Chemotaxis Induction	Chemotaxis Induction involves initiation of characteristic movement or orientation of an organism or cell along a chemical concentration gradient either toward or away from a chemical stimulus.
C40752	Chemotaxis_Inhibition	Cell_Migration_Inhibition	Chemotaxis Inhibition	Chemotaxis Inhibition involves interference with, or restraint of, characteristic movement or orientation of an organism or cell along a chemical concentration gradient either toward or away from the chemical stimulus.
C40754	Leukocyte_Trafficking_Induction	Cell_Migration_Induction	Leukocyte Trafficking Induction	Leukocyte Trafficking Induction involves initiation of circulation of white blood cells from the blood stream to tissues or secondary lymphoid organs, to the lymphatics, and back to the bloodstream via the thoracic duct.
C40755	Leukocyte_Trafficking_Inhibition	Cell_Migration_Inhibition	Leukocyte Trafficking Inhibition	Leukocyte Trafficking Inhibition involves interference with, or restraint of, circulation of white blood cells from the blood stream to tissues or secondary lymphoid organs, to the lymphatics, and back to the bloodstream via the thoracic duct.
C40757	Metastasis_Induction	Cell_Migration_Induction	Metastasis Induction	Metastasis Induction involves initiation of the spread or migration of cancer cells from one part of the body (the organ in which it first appeared) to another. The secondary tumor contains cells that are like those in the original (primary) tumor. (NCI)
C40765	Oxidative_Stress_Induction	Cell_Stress_Process	Oxidative Stress Induction	Oxidative Stress Induction involves initiation of activities that induce a disturbance in the pro-oxidant/antioxidant balance, leading to disruption of cell function by superoxide and other free radicals through damage to DNA bases, protein oxidation products, and lipid peroxidation products. Not synonymous with hypoxia or hyperoxia, oxidative stress promotes a range of degenerative disorders.
C40767	Intercellular_Communication_Induction	Intercellular_Communication_Process	Intercellular Communication Induction	Intercellular Communication Induction involves initiation of activities of biologic molecules, biologic complexes, or subcellular components involved in the transmission of signals between cells.
C40768	Intercellular_Communication_Inhibition	Intercellular_Communication_Process	Intercellular Communication Inhibition	Intercellular Communication Inhibition involves interference with, or restraint of, the activities of biologic molecules, biologic complexes, or subcellular components involved in the transmission of signals between cells.
C40772	G0_to_G1_Phase_Arrest	Cell_Cycle_Arrest	G0 to G1 Phase Arrest	G0 to G1 Phase Arrest consists of interference with, or restraint of, activities that regulate cellular capability to transition from the resting stage (between successive cell divisions) and the initial phase of the cell cycle (Gap 1 phase), preceding DNA synthesis. G1 subphases include competence, entry (G1a), progression (G1b), and assembly (G1c), based on effects of limiting growth factors, nutrients, or inhibitors.
C40775	G2_Phase_Arrest	Cell_Cycle_Arrest	G2 Phase Arrest	G2 Phase Arrest consists of interference with, or restraint of, activities that regulate the cellular capacity to transit the cell cycle phase preceding mitosis (Gap 2 phase). The chromosomes are tetraploid in this phase.
C40777	M_Phase_Arrest	Cell_Cycle_Arrest	M Phase Arrest	M Phase Arrest consists of interference with, or restraint of, activities that regulate the cellular capacity to transit the last cell cycle stage during which replicated daughter chromosomes separate into separate nuclei and cytokinesis occurs to produce separate daughter cells. M phase consists of Prophase, Metaphase, Anaphase, and Telophase. (NCI)
C40778	S_Phase_Arrest	Cell_Cycle_Arrest	S Phase Arrest	S Phase Arrest consists of interference with, or restraint of, activities that regulate the cellular capacity to transit the cell cycle stage preceding G2 phase, when the entire DNA content of the nucleus is replicated (Synthesis phase).
C40779	Cell_Senescence_Induction	Cell_Proliferation_Regulation	Cell Senescence Induction	Cell Senescence Induction involves initiation of growing old, especially from deleterious aging processes, by protoplasmic entities that make up the fundamental, structural, and functional units of cellular living organisms and consist of a nucleus (in eukaryotes) surrounded by cytoplasm contains various organelles and enclosed in a plasma membrane.
C40780	Nuclear_Division_Alteration	Cell_Cycle_Regulation	Nuclear Division Alteration	Nuclear Division Alteration involves a change in the quality of the existing state of the complex cell division process (consisting of prophase, prometaphase, metaphase, anaphase, telophase) by which two daughter nuclei receive identical complements of the chromosomes and DNA content characteristic of the original somatic cells of the species. (NCI)
C40781	Meiosis_Induction	Nuclear_Division_Alteration	Meiosis Induction	Meiosis Induction involves the initiation of activities involved in the special method of cell division, occurring in maturation of the germ cells, by which each daughter nucleus receives half the number of chromosomes characteristic of the somatic cells of the species.
C40782	Meiosis_Inhibition	Nuclear_Division_Alteration	Meiosis Inhibition	Meiosis Inhibition involves interference with, or restraint of, the activities involved in the special method of cell division, occurring in maturation of the germ cells, by which each daughter nucleus receives half the number of chromosomes characteristic of the somatic cells of the species.
C40783	Mitosis_Induction	Nuclear_Division_Alteration	Mitosis Induction	Mitosis Induction involves the initiation of activities involved in division of the eukaryotic cell nucleus to produce two daughter nuclei that contain the same chromosome and DNA content as that of the parent cell.
C40784	Mitosis_Inhibition	Nuclear_Division_Alteration	Mitosis Inhibition	Mitosis Inhibition involves interference with, or restraint of, the activities involved in division of the eukaryotic cell nucleus to produce two daughter nuclei that contain the same chromosome and DNA content as that of the parent cell.
C40785	Cellular_Digestion_Alteration	Catabolic_Process	Cellular Digestion Alteration	Cellular Digestion Alteration involves a change in the existing state of enzyme-catalyzed processes by which cellular components are broken down and destroyed.
C40786	Lysosomal_Function_Induction	Cellular_Digestion_Alteration	Lysosomal Function Induction	Lysosomal Function Induction involves initiation of activities of diverse glycoprotein hydrolytic enzymes, active at acid pH, with structure-linked latency, and stored in single unit membrane-bound and morphologically heterogeneous cytoplasmic vesicles.
C40787	Lysosomal_Function_Inhibition	Cellular_Digestion_Alteration	Lysosomal Function Inhibition	Lysosomal Function Inhibition involves interference with, or restraint of, the activities of diverse glycoprotein hydrolytic enzymes, active at acid pH, with structure-linked latency, and stored in single unit membrane-bound and morphologically heterogeneous cytoplasmic vesicles.
C40792	Cell_Membrane_Alteration	Biochemical_Process	Cell Membrane Alteration	Cell Membrane Alteration consists of a change in the quality of the existing state of activities involved in the composition, fabrication, construction, or maintenance of the regular structure and function of semipermeable lipid bilayer membranes that surround or reside within a cell.
C40793	Impaired_Cell_Membrane_Integrity	Pathologic_Process	Impaired Cell Membrane Integrity	Impaired Cell Membrane Integrity consists of activities that interfere with, or restrain, fabrication, construction, or maintenance of the regular structure and function of semipermeable lipid bilayer membranes that surround or reside within a cell.
C40794	Cell_Wall_Alteration	Biochemical_Process	Cell Wall Alteration	Cell Wall Alteration involves a change in the existing structure or function of the rigid protective structure outside of, and joined to, the plasma membrane of plant cells and most prokaryotic cells that maintains cell shape.
C40795	Cytoskeleton_Alteration	Biochemical_Process	Cytoskeleton Alteration	Cytoskeletal Alteration consists of a change in the construction, maintenance, or function of the network of protein scaffolding, filaments, tubules, and interconnecting filamentous bridges (microfilaments, microtubules, intermediate filaments, and associated proteins) that give shape, structure, and organization to the cytoplasm and to a cell.
C40796	Cytoskeletal_Synthesis_Inhibition	Metabolic_Process	Cytoskeletal Synthesis Inhibition	Cytoskeletal Synthesis Inhibition consists of interference with, or restraint of, the activities of enzymes involved in the formation of the protein scaffolding network of filaments, tubules, and interconnecting filamentous bridges that give shape, structure, and organization to the cytoplasm and a cell its shape.
C40797	Impaired_Cytoskeletal_Integrity	Pathologic_Process	Impaired Cytoskeletal Integrity	Impaired Cytoskeletal Integrity consists of activities that interfere with, or restrain, fabrication, construction, or maintenance of the network of protein scaffolding, filaments, tubules, and interconnecting filamentous bridges (microfilaments, microtubules, intermediate filaments, and associated proteins) that give shape, structure, and organization to the cytoplasm and to a cell.
C40798	Microtubule_Alteration	Cytoskeleton_Alteration	Microtubule Alteration	Microtubule Alteration consists of a change in the composition, construction, maintenance, or function of filaments of variable length in the cytoskeleton composed primarily of conserved alpha, beta, and gamma tubulin that support movement of chromosomes or chromatids during mitosis and meiosis; and give shape, structure, and organization to the cytoplasm and to a cell.
C40799	Microtubule_Assembly_Inhibition	Microtubule_Alteration	Microtubule Assembly Inhibition	Microtubule Assembly Inhibition consists of interference with, or restraint of, activities involved in construction or maintenance of filaments of variable length in the cytoskeleton composed primarily of conserved alpha, beta, and gamma tubulin that support movement of chromosomes or chromatids during mitosis and meiosis; and give shape, structure, and organization to the cytoplasm and to a cell.
C40800	Chromatin_Structure_Alteration	Biochemical_Process	Chromatin Structure Alteration	Chromatin Structure Alteration involves a change in the existing euchromatic and heterochromatic configuration of nuclear fibrils of deoxyribonucleic acid with attached proteins (histone and non-histone).
C40801	Cellular_Transport_Alteration	Transport_Process	Cellular Transport Alteration	Cellular Transport Alteration involves a change in the quality of the existing state of any subcellular or molecular event, process, or condition involved in translocation of a biological macromolecule from one site or compartment to another, entirely within a cell. (NCI)
C40803	Endocytosis_Induction	Cellular_Transport_Alteration	Endocytosis Induction	Endocytosis Induction involves initiation of cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles by invagination of the plasma membrane.
C40804	Phagocytosis_Induction	Endocytosis_Induction	Phagocytosis Induction	Phagocytosis Induction involves initiation of the process of endocytosis of particulate material by phagocytes, such as microorganisms or cellular fragments and debris, into membranous phagosomes that fuse with lysosmes and result in digestion of the ingested material; an important defense against infection. (NCI)
C40805	Endocytosis_Inhibition	Cellular_Transport_Alteration	Endocytosis Inhibition	Endocytosis Inhibition involves interference with, or restraint of, cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles by invagination of the plasma membrane.
C40806	Phagocytosis_Inhibition	Endocytosis_Inhibition	Phagocytosis Inhibition	Phagocytosis Inhibition involves interference with, or restraint of, the process of endocytosis of particulate material by phagocytes, such as microorganisms or cellular fragments and debris, into membranous phagosomes that fuse with lysosmes and result in digestion of the ingested material; an important defense against infection. (NCI)
C40808	Exocytosis_Induction	Cellular_Transport_Alteration	Exocytosis Induction	Exocytosis Induction involves initiation of the cellular release of secretory products within membrane-limited vesicles or granules.
C40809	Exocytosis_Inhibition	Cellular_Transport_Alteration	Exocytosis Inhibition	Exocytosis Inhibition involves interference with, or restraint of, the cellular release of secretory products granules.
C40811	Glucose_Transport_Induction	Cellular_Transport_Alteration	Glucose Transport Induction	Glucose Transport Induction consists of the initiation of subcellular or molecular processes directly involved in the physical translocation from one site or compartment to another (typically, extracellular to intracellular) of the simple C6H12O6 monosaccharide, glucose, that acts as an energy source for cells.(NCI)
C40812	Glucose_Transport_Inhibition	Cellular_Transport_Alteration	Glucose Transport Inhibition	Glucose Transport Inhibition involves interference with, or restraint of, subcellular or molecular processes directly involved in the physical translocation from one site or compartment to another (typically, extracellular to intracellular) of the simple C6H12O6 monosaccharide, glucose, that acts as an energy source for cells.(NCI)
C40813	Iodine_Uptake_Alteration	Cellular_Transport_Alteration	Iodine Uptake Alteration	Iodine Uptake Alteration involves a change in the quality of the existing state of subcellular or molecular processes directly involved in the physical translocation from the extracellular to intracellular compartment of the nutritionally essential nonmetallic halogen element, Iodine, which is especially important in thyroid hormone synthesis.
C40815	Vitamin_Uptake_Alteration	Cellular_Transport_Alteration	Vitamin Uptake Alteration	Vitamin Uptake Alteration involves a change in the quality of the existing state of subcellular or molecular processes directly involved in the physical translocation from the extracellular to intracellular compartment of trace dietary organic nutrient substances required for normal metabolic function, often as enzyme cofactors or cofactor precursors.
C40817	Multidrug_Resistance_Induction	Resistance_Process	Multidrug Resistance Induction	Multidrug Resistance Induction involves initiation of activities of biologic molecules or complexes involved in processes that increase the ability of cancer cells to counteract, defeat, or withstand the effects of multiple chemotherapeutic agents. Mechanisms involve expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, decreased topoisomerase II activity, and changes in various cellular proteins.
C40818	Multidrug_Resistance_Inhibition	Resistance_Process	Multidrug Resistance Inhibition	Multidrug Resistance Inhibition involves interference with, or restraint of, the activities of biologic molecules or complexes involved in processes that increase the ability of cancer cells to counteract, defeat, or withstand the effects of multiple chemotherapeutic agents. Mechanisms involve decreased expression of multidrug efflux pumps (p-glycoprotein), altered glutathione metabolism, increased topoisomerase II activity, and changes in various cellular proteins. Inhibition results in increased transport of drug into, or decreased transport out of, cells and increased effectiveness of chemotherapeutic agents.
C40820	Signal_Transduction_Induction	Signal_Transduction_Alteration	Signal Transduction Induction	Signal Transduction Induction involves the initiation of activity in cellular processes by which a cell propagates information from an extracellular signal through a series of biochemical reactions inside the cell to produce biological responses to events in the environment or internal milieu.
C40821	Signal_Transduction_Inhibition	Signal_Transduction_Alteration	Signal Transduction Inhibition	Signal Transduction Inhibition involves interference with, or restraint of, the activities in cellular processes by which a cell propagates information from an extracellular signal through a series of biochemical reactions inside the cell to produce biological responses to events in the environment or internal milieu.
C40823	Keratinization_Induction	Biosynthesis	Keratinization Induction	Keratinization Induction consists of initiation of activities involved in proliferation and maturation of tightly bound keratinocytes transiting passively from the basal to the corneal layer of the skin.
C40824	Keratinization_Inhibition	Metabolic_Process	Keratinization Inhibition	Keratinization Inhibition involves interference with, or restraint of, activities involved in proliferation and maturation of tightly bound keratinocytes transiting passively from the basal to the corneal layer of the skin.
C40827	DNA_Replication_Induction	Replication-Associated_Process	DNA Replication Induction	DNA Replication Induction involves initiation of activities of biologic molecules or complexes involved in the process by which the two strands of a DNA double helix separate and each strand acts as a template for the synthesis of a complementary strand by specific base pairing.
C40828	DNA_Replication_Inhibition	Replication-Associated_Process	DNA Replication Inhibition	DNA Replication Inhibition involves interference with, or restraint of, the activities of biologic molecules or complexes involved in the process by which the two strands of a DNA double helix separate and each strand acts as a template for the synthesis of a complementary strand by specific base pairing.
C40833	Lymphocyte_Activation	Immune_Cell_Activation	Lymphocyte Activation	Lymphocyte Activation involves stimulation of the production and activity of lymphocytes. Formed in lymphoid tissue, lymphocytes are white blood cells that can generally be classified as either T- or B-cells. T-lymphocytes provide cell-mediated immunity, while B-lymphocytes produce antibodies that provide humoral immunity.  Stimulation increases the immune response to invading substances.
C40839	Myeloid_Cell_Activation	Immune_Cell_Activation	Myeloid Cell Activation	Myeloid Cell Activation involves stimulation of the production and activity of myeloid cells. Formed in the bone marrow, myeloid cells are leukocytes that defend the body against foreign substances. These cells include monocytes and granulocytes that protect the body against invading substances by ingesting or phagocytizing them.
C40844	Immune_Cell_Suppression	Immune_Function	Immune Cell Suppression	Immune Cell Suppression consists of interference with, or restraint of, the activity of one or more lymphoid or myeloid cell types associated with the immune response.
C40846	Lymphocyte_Suppression	Immune_Cell_Suppression	Lymphocyte Suppression	Lymphocyte Suppression involves interference with, or restraint of, the production and activity of lymphocytes. Formed in lymphoid tissue, lymphocytes are white blood cells that can generally be classified as either T- or B-cells. T-lymphocytes provide cell-mediated immunity, while B-lymphocytes produce antibodies that provide humoral immunity. Suppression decreases the ability of lymphocytes to mount an immune response to invading substances.
C40850	Myeloid_Cell_Suppression	Immune_Cell_Suppression	Myeloid Cell Suppression	Myeloid Cell Suppression involves interference with, or restraint of, the production and activity of myeloid cells. Formed in the bone marrow, myeloid cells are leukocytes that defend the body against foreign substances. These cells include monocytes and granulocytes that protect the body against invading substances by ingesting or phagocytizing them. Suppression decreases the body's ability to combat disease and toxic substances.
C40854	Platelet_Activation	Coagulation_Process	Platelet Activation	Platelet Activation involves initiation of a set of stimulated platelet activities involved in aggregation of platelets and fibrin during blood coagulation. Containing mitochondria and granules of active enzymes, blood platelets are non-nucleated irregular disk-shaped cytoplasmic fragments of megakaryocytes and shed from the marrow sinus into the peripheral blood.
C40856	Antiemetic_Effect	Neurologic_Effect	Antiemetic Effect	An Antiemetic Effect involves suppression of nausea and vomiting. Emesis is a complex process coordinated by a central emesis center located in the lateral reticular formation of the mid-brainstem. Inhibition of certain neurotransmitters (e.g., 5-HT) or their receptors located in this region inhibits emesis.
C40857	Antiinflammatory_Effect	Inflammation_Process	Antiinflammatory Effect	An Antiinflammatory Effect involves interference with, or restraint of, local events that constitute part of innate immunity, involve increased blood supply, and infiltration and activity of leukocytes at a site of injury or disease. Inflammation is induced by release of vasodilatory, opsonizing, and chemotactic mediators that attract phagocytizing macrophages and leukocytes; dilate local blood vessels, increasing local blood flow and capillary permeability; and induce pain.
C40858	Antimicrobial_Effect	Biochemical_Process	Antimicrobial Effect	An Antimicrobial Effect involves interference with, or restraint of, the activities of biologic molecules and complexes, or cellular components involved in the life cycle of a microorganism, resulting in suppression of microbial growth.  Mechanisms to suppress growth include inhibition of cell wall synthesis; increased cell wall permeability; protein synthesis inhibition; and inhibition of reverse transcriptase and protease.
C40859	Antipruritic_Effect	Neurologic_Effect	Antipruritic Effect	An Antipruritic Effect involves suppression of an itching sensation caused by histamine stimulation of epidermal nerve endings. Inhibition of histamine or histamine release can produce an antipruritic effect.
C40860	Sunscreen_Effect	Biophysical_Process	Sunscreen Effect	A Sunscreen Effect involves absorption, reflection, or scattering of ultraviolet radiation, resulting in decreased penetration of the skin by ultraviolet radiation.  Decreased radiation penetration reduces the risk of DNA damage and skin cancer.
C40863	Cardiovascular_Effect	Retired_Concepts	Cardiovascular Effect	A Cardiovascular Effect involves a change in the existing function of biologic molecules and complexes, or cellular, cell, or tissue components of the heart and vascular system by which blood is pumped and circulated through the body to provide tissues with oxygen and nutrients and to remove waste products.
C40864	Vascular_Permeability_Alteration	Cardiovascular_Alteration	Vascular Permeability Alteration	Vascular Permeability Alteration involves a qualitative change in the existing capacity of substances to pass from the vascular lumen, through a blood vessel wall, into surrounding tissue, or vice versa.
C40866	Vasoconstriction	Cardiovascular_Alteration	Vasoconstriction	Vasoconstriction involves narrowing of a blood vessel lumen due to smooth muscle contraction in the vessel wall and leads to decreased blood flow.
C40867	Vasodilation	Cardiovascular_Alteration	Vasodilation	Vasodilation involves widening of a blood vessel lumen due to smooth muscle relaxation in the vessel wall and leads to increased blood flow.
C40869	Thrombolysis_Induction	Coagulation_Process	Thrombolysis Induction	Thrombolysis Induction involves initiation of a complex series of events that result in dissolution of a thrombus (blood clot) and restoration of normal blood flow.
C40870	Connective_Tissue_Alteration	Multicellular_Process	Connective Tissue Alteration	Connective Tissue Alteration involves a qualitative change in the existing state of supporting tissue derived from mesenchyme that binds other tissues and consists of various cell types embedded in a fibrous and ground substance extracellular matrix.
C40912	Immunopotentiation_Effect	Immunoregulation	Immunopotentiation	An Immunopotentiation Effect involves stimulation of biologic molecules and complexes, or cellular, cell, or tissue components of a normal immune response.
C40913	Immunosuppressive_Effect	Immunoregulation	Immunosuppressive Effect|Immunosuppression Effect	An Immunosuppressive Effect involves interference with, or restraint of, the function of biologic molecules and complexes, or cellular, cell, or tissue components of a normal immune response.
C40917	Bone_Formation_Inhibition	Musculoskeletal_Process	Bone Formation Inhibition	Bone Formation Inhibition involves interference with, or restraint of, synthesis by osteoblasts of the hard connective tissue that constitutes the vertebrate skeleton and consists of a matrix of collagenous fibers impregnated chiefly with calcium phosphate and calcium carbonate.
C40918	Bone_Formation_Stimulation	Musculoskeletal_Process	Bone Formation Stimulation	Bone Formation Stimulation involves initiation of synthesis by osteoblasts of the hard connective tissue that constitutes the vertebrate skeleton and consists of a matrix of collagenous fibers impregnated chiefly with calcium phosphate and calcium carbonate.
C40920	Bone_Resorption_Inhibition	Musculoskeletal_Process	Bone Resorption Inhibition	Bone Resorption Inhibition involves interference with, or restraint of, absorption and removal of the hard connective tissue that constitutes the vertebrate skeleton and consists of a matrix of collagenous fibers impregnated chiefly with calcium phosphate and calcium carbonate and release of bone salts (phosphorus and, especially, calcium) into the extracellular fluid by osteoclasts, activated by parathyroid hormone.
C40921	Bone_Resorption_Stimulation	Musculoskeletal_Process	Bone Resorption Stimulation	Bone Resorption Stimulation involves initiation of absorption and removal of the hard connective tissue that constitutes the vertebrate skeleton and consists of a matrix of collagenous fibers impregnated chiefly with calcium phosphate and calcium carbonate and release of bone salts (phosphorus and, especially, calcium) into the extracellular fluid by osteoclasts, activated by parathyroid hormone.
C40922	Neurologic_Effect	Neurologic_Process	Neurologic Effect	A Neurologic Effect involves a change in the existing function of biologic molecules and complexes, or cellular, cell, or tissue components of the nervous system.
C40924	Neuron_Conduction_Induction	Neurologic_Effect	Neuron Conduction Induction	Neuron Conduction Induction involves initiation of activities that propagate the transfer of the electrochemical action potential process along nerve fibers away from the cell body.
C40925	Neuron_Conduction_Inhibition	Neurologic_Effect	Neuron Conduction Inhibition	Neuron Conduction Inhibition involves interference with, or restraint of, activities that propagate the transfer of the electrochemical action potential process along nerve fibers away from the cell body.
C40928	Female_Reproductive_System_Alteration	Reproductive_System_Process	Female Reproductive System Alteration	Female Reproductive System Alteration involves a change in the quality of the existing state of functionality of one or more female reproductive organs or organ processes.
C40929	Cervical_Function_Alteration	Female_Reproductive_System_Alteration	Cervical Function Alteration	Cervical Function Alteration involves a change in the quality of the existing biochemical composition or functionality of the cervix.
C40930	Ovulation_Alteration	Female_Reproductive_System_Alteration	Ovulation Alteration	Ovulation Alteration consists of a change in the quality of the existing state of processes involved in release of an egg from the ovary. Mechanisms of alteration include increased or decreased secretion of Luteinizing Hormone or Follicle Stimulating Hormone.
C40931	Uterine_Function_Alteration	Female_Reproductive_System_Alteration	Uterine Function Alteration	Uterine Function Alteration involves a qualitative change in the existing activity of the hollow muscular female organ in which an impregnated ovum develops into a child.
C40932	Uterine_Proliferative_Phase_Alteration	Uterine_Function_Alteration	Uterine Proliferative Phase Alteration	Uterine Proliferative Phase Alteration involves a change in the existing state of any process involving the uterine lining during the early stage of the menstrual cycle (Proliferative Phase) that may affect endometrial proliferation and alter uterine function.
C40933	Vaginal_Function_Alteration	Female_Reproductive_System_Alteration	Vaginal Function Alteration	Vaginal Function Alteration involves a qualitative change in the existing activity of the female genital canal, extending from the uterus to the vulva.
C40934	Male_Reproductive_System_Alteration	Reproductive_System_Process	Male Reproductive System Alteration	Male Reproductive System Alteration involves a qualitative change in the existing activity of the male reproductive organs, which include the penis, scrotum, urethra, testis, epididymis, ductus deferens, seminal vesicle, ejaculatory duct, prostate, and bulbourethral gland.
C40935	Penile_Erectile_Alteration	Male_Reproductive_System_Alteration	Penile Erectile Alteration	Penile Erectile Alteration involves a change in quality of the ability of the penis to achieve and maintain an erection. Mechanisms of alteration include induction or inhibition of blood flow to the corpus cavernosa and nerve stimuli to the penile musculature.
C40936	Prostatic_Alteration	Male_Reproductive_System_Alteration	Prostatic Alteration	Prostatic Alteration involves a qualitative change in the existing activity of the accessory sex gland (prostate gland) of the male reproductive system that surrounds the neck of the bladder and urethra and secretes into seminal fluid acid phosphatase, citric acid, and proteolytic enzymes that liquefy coagulated semen.
C40937	Prostatic_Secretion_Alteration	Prostatic_Alteration	Prostatic Secretion Alteration	Prostatic Secretion Alteration involves a qualitative change in existing activities involved in release into seminal fluid of acid phosphatase, citric acid, and proteolytic enzymes that liquefy coagulated semen, from the accessory sex gland of the male reproductive system that surrounds the neck of the bladder and urethra (prostate gland).
C40938	Prostatic_Size_Alteration	Prostatic_Alteration	Prostatic Size Alteration	Prostatic Size Alteration involves a change in the dimensions of the accessory sex gland (prostate gland) of the male reproductive system that surrounds the neck of the bladder and urethra and secretes into seminal fluid acid phosphatase, citric acid, and proteolytic enzymes that liquefy coagulated semen.
C40940	Respiratory_Mucosal_Edema_Alteration	Respiratory_Process	Respiratory Mucosal Edema Alteration	Respiratory Mucosal Edema Alteration involves a change in the quality of the existing state of swelling in the respiratory tract mucosa due to abnormally large amounts of fluid in the extracellular space. Such alterations may increase or decrease blockage of airways.
C40942	Bronchoconstriction	Respiratory_Process	Bronchoconstriction	Bronchoconstriction involves narrowing of air passage lumina, typically due to bronchial smooth muscle contraction, and leads to decreased air flow.
C40943	Bronchodilation	Respiratory_Process	Bronchodilation	Bronchodilation involves widening of air passage lumina, typically due to bronchial smooth muscle relaxation, and leads to increased air flow.
C40944	Respiratory_Secretion_Alteration	Respiratory_Process	Respiratory Secretion Alteration	Respiratory Secretion Alteration involves a change in the quality of the existing state of fluid release from cells in the respiratory tract. Such alterations increase or decrease the surfactant, protective, and lubricating effects of respiratory secretions.
C40945	Respiratory_Secretion_Viscosity_Alteration	Respiratory_Secretion_Alteration	Respiratory Secretion Viscosity Alteration	Respiratory Secretion Viscosity Alteration involves a change in the quality of the existing state of thickness of fluids released from cells in the respiratory tract.  Such alterations increase or decrease blockage of air passages.
C40946	Skin-Associated_Alteration	Organismal_Process	Skin-Associated Alteration	Skin-Associated Alteration involves a qualitative change in the existing state of activities of skin-related glands, tissues, and cells, resulting in increased or decreased integrity, functionality, or activity of skin-related structures, such as sebaceous glands.
C40947	Sebaceous_Gland_Alteration	Skin-Associated_Alteration	Sebaceous Gland Alteration	Sebaceous Gland Alteration involves a change in the existing function of cellular, cell, or tissue components of the holocrine glands of the skin situated in the corium and that secrete sebum.
C40952	Chaperone_Protein_Interaction	Molecular_Interaction	Chaperone Protein Interaction	Chaperone Protein Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction by cellular proteins that mediate assembly/disassembly, stabilization, and transmembrane translocation of other polypeptides or complexes, but which are not components of those final structures.
C40953	Free_Radical_Interaction	Molecular_Interaction	Free Radical Binding	Free Radical Binding involves temporary interaction with chemically unstable and highly reactive molecules (free radicals) having an unsatisfied electron valence pair. Agents of tissue damage through exposure to radiation, environment chemicals, and aging, reactive free radicals stabilize themselves by appropriating an electron from a nearby molecule and damaging that molecule by altering the electron number in its outermost electron shell.
C40954	GD2_Binding_Interaction	Antigen_Binding_Interaction	GD2 Binding	GD2 Binding Interaction involves non-covalent attachment of a molecule through intermolecular physical forces of attraction to a widely expressed cell surface ganglioside antigen, GD2.
C40955	GD3_Binding_Interaction	Antigen_Binding_Interaction	GD3 Binding	GD3 Binding Interaction involves non-covalent attachment of a molecule through intermolecular physical forces of attraction to a cell surface liposaccharide disialoganglioside, GD3.
C40957	Testicular_Seminoma_Cribriform_Variant	Testicular_Seminoma	Testicular Seminoma, Cribriform Variant
C40958	Testicular_Seminoma_Pseudoglandular_Variant	Testicular_Seminoma	Testicular Seminoma, Pseudoglandular Variant
C40959	Testicular_Seminoma_Tubular_Variant	Testicular_Seminoma	Testicular Seminoma, Tubular Variant
C40960	Chromogenic_in_situ_Hybridization	in_situ_Hybridization	Chromogenic in situ Hybridization|CISH	Chromogenic in situ hybridization is a technique that combines the sequence-specific detection aspects of FISH with the simple detection methods of immunohistochemistry. Briefly, sequence-specific probes are hybridized to cells fixed on slides and the sequestered probe is visualized by a peroxidase reaction. It has the advantage of being a less costly assay that does not require fluorescence microscopy with results that are stable over time.
C40961	Partial_Hysterectomy	Hysterectomy	Partial Hysterectomy	A surgical procedure to remove the uterine body. -- 2004
C40962	Polyembryoma_of_the_Testis	Malignant_Testicular_Germ_Cell_Tumor	Testicular Polyembryoma|Polyembryoma of Testis|Polyembryoma of the Testis
C40964	_4p16_3-p16_1	Chromosome_Band	4p16.3-p16.1	A chromosome band present on 4p
C40965	CHEK2_Gene	Serine-Threonine_Protein_Kinase_Gene	CHEK2 Gene|CDS1|CHEK2|CHK2|CHK2 Checkpoint Homolog (S. Pombe) Gene|PP1425|RAD53	Highly expressed in testis, spleen, colon, and peripheral leukocytes, human CHEK2 Gene (CDS1 Ser/Thr Kinase Family) encodes 543-aa 61-kDa nuclear Serine/Threonine-Protein Kinase CHK2, a cell cycle checkpoint regulator containing a protein interaction FHA domain for activation in response to DNA damage. Rapidly phosphorylated and activated in response to DNA damage and replication block stress signal transduction, CHEK2 phosphorylates and inhibits CDC25C phosphatase; stabilizes p53 protein leading to G1 cell cycle arrest and preventing mitosis; and phosphorylates BRCA1 allowing survival after DNA damage. CHEK2 defects are associated with Li-Fraumeni syndrome and predisposition to prostate cancer, osteosarcoma, breast cancer, and brain tumors. (NCI)
C40966	Serine-Threonine_Protein_Kinase-CHK2	Serine-Threonine_Protein_Kinase	Serine/Threonine-Protein Kinase CHK2|CDS1|CHEK2|CHK2|CHK2 Checkpoint Homolog|CHK2 Homolog|Checkpoint-Like Protein CHK2|Protein Kinase CHK2	Highly expressed in testis, spleen, colon, and peripheral leukocytes by human CHEK2 Gene (CDS1 Ser/Thr Kinase Family), 543-aa 61-kDa nuclear Serine/Threonine-Protein Kinase CHK2 is a cell cycle checkpoint regulator containing a protein interaction FHA domain for activation in response to DNA damage. Rapidly phosphorylated and activated in response to DNA damage and replication block stress signal transduction, CHEK2 phosphorylates and inhibits CDC25C phosphatase; stabilizes p53 protein leading to G1 cell cycle arrest and preventing mitosis; and phosphorylates BRCA1 allowing survival after DNA damage. CHEK2 defects are associated with Li-Fraumeni syndrome and predisposition to prostate cancer, osteosarcoma, breast cancer, and brain tumors. (NCI)
C40967	MSX1_Gene	Homeobox_Gene	MSX1 Gene|HOX7|HYD1|MSH Homeo Box Homolog 1 (Drosophila) Gene|MSX1	Human MSX1 Gene (MSH Family) encodes 297-aa 31-kDa nuclear Homeobox Protein MSX-1, a transcription repressor involved in cranofacial development, odontogenesis, and perhaps limb-pattern formation. MSX1 Defects cause hypodontia (HYD1), Witkop syndrome, nonsyndromic orofacial cleft (OFC) and possibly (deleted in) Wolf-Hirschorn syndrome (WHS). (NCI)
C40968	Homeobox_Protein_MSX-1	Homeobox_Protein	Homeobox Protein MSX-1|HOX7|Homeo Box 7|MSH Homeo Box Homolog 1|MSX1	Encoded by human MSX1 Gene (MSH Family), 297-aa 31-kDa nuclear Homeobox Protein MSX-1 is a transcription repressor involved in craniofacial development, odontogenesis, and perhaps limb-pattern formation. MSX1 Defects cause hypodontia (HYD1), Witkop syndrome, nonsyndromic orofacial cleft (OFC) and possibly (deleted in) Wolf-Hirschorn syndrome (WHS). (NCI)
C40970	Angiocentric_Immunoproliferative_Lesion	Lymphocytic_Neoplasm	Angiocentric Immunoproliferative Lesion|AIL
C40971	Examination_Under_Anesthesia	Examination	Examination Under Anesthesia	A medical inspection, qualified according to the methods employed, as physical examination, radiologic examination, diagnostic imaging examination, etc., performed under conditions of patient's complete or partial local or general insensibility to pain with or without the loss of consciousness, induced by an anesthetic agent or by non-pharmacological anesthesia technique.
C40972	Central_Venous_Cannula_Insertion	Procedure	Central Venous Cannula Insertion	A procedure of surgical placement of a catheter, which lumen is usually occupied by a trocar, into the central vein (internal jugular, subclavian, and femoral often used) or veins, to provide vascular access for measurement of hemodynamic variables that cannot be measured accurately by noninvasive means.  It also can be used to deliver medications that were too potent or too toxic to be administered through peripheral access, for parenteral nutrition delivery; and for placing wires and pulmonary artery catheters. Central veins are usually cannulated percutaneously. The procedure is associated with many adverse events and has to be performed or supervised by an experienced physician.
C40973	Non-CTC	General_Modifier	Non-CTC	Designates that a term or concept does not use the NCI Common Toxicity Criteria as a reference.
C40974	First_Name	Name	First Name|Forename|Given Name	A word or group of words indicating a person's first (personal or given) name; the name that precedes the surname.
C40975	Last_Name	Name	Last Name|Family Name|Surname	A word or group of words indicating a person's last (family) name.
C40976	Journal	Document_Type	Journal	A periodical dedicated to a particular subject.
C40978	Telephone_Number	Number	Telephone Number|Phone|Phone Number	A sequence of decimal digits (0-9) that is used for identifying a destination telephone line or other device in a telephone network.
C40982	Consensus_Sequence	Sequence	Consensus Sequence	A sequence pattern derived from the alignment of multiple sequences that represents the nucleotide or amino acid most likely to occur at each position in a sequence. (Drug Discovery & Development, www.dddmag.com glossary)
C40983	Abnormal_Large_Granular_Lymphocyte	Abnormal_Lymphocyte	Abnormal Large Granular Lymphocyte
C40984	Contig	Conceptual_Entities	Contig	A group of overlapping clones representing regions of the genome; the contiguous sequence of DNA created by assembling these overlapping chromosome fragments.
C40985	Engineered_Gene	Gene	Engineered Gene	A gene that has been artificially altered in sequence or structure.
C40986	Diffuse_Immunoblastic_Proliferation	Cellular_Infiltrate	Diffuse Immunoblastic Proliferation
C40987	Induced_Mutation	Mutation	Induced Mutation|Induced DNA Alteration|Induced Sequence Alteration	A mutation triggered by outside influences (e.g., radiation, chemicals or other means) as opposed to those created by the inherent infidelity of DNA polymerase.
C40988	Case_Report_Form	Form	Case Report Form|CRF	A printed, optical, or electronic document designed to record all of the clinical study-required information stipulated in the protocol to be reported to the sponsor on each trial subject.
C40989	Cervical_Lymphadenopathy	Lymphadenopathy	Cervical Lymphadenopathy
C40990	Plasmacytic_Infiltrate	Cellular_Infiltrate	Plasmacytic Infiltrate
C40991	Massive_Sinusoidal_Histiocytic_Infiltrate	Histiocytosis	Massive Sinusoidal Histiocytic Infiltrate
C40992	Homologous_Protein	Protein	Homologous Protein|Protein Homolog	A protein similar in structure and evolutionary origin to a protein in another species.
C40993	S-100_Positive_Histiocytes_Present	Positive_Immunophenotypic_Test_Result	S-100-Positive Neoplastic Cells Present
C40994	Sex_Distribution	Properties_or_Attributes	Sex Distribution	A description of the distribution of a trait between sexes in a population; number of males and females in a given population.
C40995	CD68_Positive_Histiocytes_Present	Positive_Immunophenotypic_Test_Result	CD68-Positive Neoplastic Cells Present
C40996	CD14_Positive_Histiocytes_Present	Positive_Immunophenotypic_Test_Result	CD14-Positive Neoplastic Cells Present
C40998	Positive_Immunophenotypic_Test_Result	Positive_Test_Result	Positive Immunophenotypic Test Result
C40999	Atypical_Histiocyte	Abnormal_Macrophage	Atypical Histiocyte
C41000	UML_Entity	NCI_Administrative_Concepts	UML Entity|caBIO Entity	caBIO domain objects represent entities found in biomedical research.  The objects simulate the behavior of components such as genes, chromosomes, sequences, libraries, clones, and ontologies. The caBIO objects include the behavior (operations) and the relationships that the actual bioinformatics objects have, for example, a gene can retrieve its EST's, SNP's, or clones. (from National Cancer Institute Center for Bioinformatics)
C41001	Peribronchial_and_Lobular_Septal_Involvement_Only	Morphologic_Finding	Peribronchial and Lobular Septal Involvement Only
C41002	Data_Element	NCI_Administrative_Concepts	Data Element	A unit of data for which the definition, identification, representation and permissible values are specified by means of a set of attributes. (ISO 11179)
C41004	Solitary_Nodule	Nodule	Solitary Nodule
C41005	Reactive_Germinal_Centers_Present	Morphologic_Finding	Reactive Germinal Centers Present
C41006	Germinal_Centers_with_Prominent_Hyalinized_Vessels_Present	Morphologic_Finding	Germinal Centers with Prominent Hyalinized Vessels Present
C41007	Sheets_of_Interfollicular_Plasma_Cells_Present	Abnormal_Cells_Present	Sheets of Interfollicular Plasma Cells Present
C41009	Qualifier	Properties_or_Attributes	Qualifier|Modifier	A term that helps define and render a concept unique.
C41010	Single_Nucleotide_Polymorphism_in_Regulatory_Sequences	Single_Nucleotide_Polymorphism	Regulatory Region SNP|Single Nucleotide Polymorphism in Regulatory Sequences|rSNP	Single Nucleotide Polymorphism in Regulatory Sequences (Regulatory Region SNP) consists of a variation at an appreciable frequency between individuals of a single interbreeding population of a single nucleotide, due to base substitution, at an equivalent location within a gene region that is involved in the regulation of genetic processes, such as transcription and replication.
C41011	_5p13-p11	Chromosome_Band	5p13-p11	A chromosome band present on 5p
C41012	_11p15_3-p15_1	Chromosome_Band	11p15.3-p15.1	A chromosome band present on 11p
C41013	_7p22_1	Chromosome_Band	7p22.1	A chromosome band present on 7p
C41014	_14q11-q12	Chromosome_Band	14q11-q12	A chromosome band present on 14q
C41015	_5q22_3	Chromosome_Band	5q22.3	A chromosome band present on 5q
C41016	GHR_Gene	Receptor_Gene	GHR Gene|GHR|Growth Hormone Receptor Gene	Widely expressed, human GHR Gene (Cytokine Receptor I Subfamily 1) encodes Growth Hormone Receptor, a type I membrane receptor for growth hormone with a ligand-binding extracellular domain (GHBP); a FnIII domain; a WSXWS motif; a cytoplasmic UbE motif for ubiquitination and internalization; and a cytoplasmic JAK interaction box 1 motif. Produced by cleavage by cell surface ADAM17, secreted GHBP may modulate GH signaling; GH appears to inhibit ADAM17. Tyr phosphorylated on GH binding by JAK2, homodimerized GHR appears to activate JAK2/STAT pathways that produce IGF1, which activates mitogenic and anabolic growth responses. SOCS3 may inhibit JAK2 activation while CIS and SOCS2 may inhibit STAT5 activation by GHR. GHR defects cause Laron dwarfism and idiopathic short stature. (NCI)
C41017	Growth_Hormone_Receptor	Cell_Surface_Receptor	Growth Hormone Receptor|GH Receptor|GHR|Somatotropin Receptor	Widely expressed by human GHR Gene (Cytokine Receptor I Subfamily 1), Growth Hormone Receptor is a type I membrane receptor for growth hormone with a ligand-binding extracellular domain (GHBP); a FnIII domain; a WSXWS motif; a cytoplasmic UbE motif for ubiquitination and internalization; and a cytoplasmic JAK interaction box 1 motif. Produced by cleavage by cell surface ADAM17, secreted GHBP may modulate GH signaling; GH appears to inhibit ADAM17. Tyr phosphorylated on GH binding by JAK2, homodimerized GHR appears to activate JAK2/STAT pathways that produce IGF1, which activates mitogenic and anabolic growth responses. SOCS3 may inhibit JAK2 activation while CIS and SOCS2 may inhibit STAT5 activation by GHR. GHR defects cause Laron dwarfism and idiopathic short stature. (NCI)
C41018	Osteosclerotic_Lesion	Radiologic_Finding	Osteosclerotic Lesion
C41019	HRH2_Gene	G_Protein-Coupled_Receptor_Gene	HRH2 Gene|H2R|HRH2|Histamine Receptor H2 Gene	Human HRH2 Gene (GPCR1 Family) encodes 359-aa 40-kDa Histamine Receptor H2, an integral membrane protein that stimulates gastric acid secretion, regulates gastrointestinal motility and intestinal secretion, and may regulate cell growth and differentiation. Histamine is a ubiquitous messenger released from mast cells, enterochromaffin-like cells, and neurons; its actions are mediated by histamine receptors H1, H2, H3 and H4. HRH2 activity appears to be mediated by separate G proteins that activate adenylyl cyclase and PKC signaling pathways. (NCI)
C41020	Histamine_Receptor-H2	G_Protein-Coupled_Receptor	Histamine Receptor H2|Gastric Receptor I|H2R|HRH2|Histamine H2 Receptor|Histamine-2 Receptor	Encoded by human HRH2 Gene (GPCR1 Family), 359-aa 40-kDa Histamine Receptor H2 is an integral membrane protein that stimulates gastric acid secretion, regulates gastrointestinal motility and intestinal secretion, and may regulate cell growth and differentiation. Histamine is a ubiquitous messenger released from mast cells, enterochromaffin-like cells, and neurons; its actions are mediated by histamine receptors H1, H2, H3 and H4. HRH2 activity appears to be mediated by separate G proteins that activate adenylyl cyclase and PKC signaling pathways. (NCI)
C41021	TACR1_Gene	G_Protein-Coupled_Receptor_Gene	TACR1 Gene|NK1R|SPR|TAC1R|TACR1|Tachykinin Receptor 1 Gene	Human TACR1 Gene (GPCR1 Family) encodes 407-aa 46-kDa Tachykinin Receptor 1, a receptor for the tachykinin neuropeptide substance P and an integral membrane protein with 7 hydrophobic transmembrane regions that probably associates with G proteins that activate a phosphatidylinositol-calcium second messenger system. TACR1 is also involved in mediation of phosphatidylinositol metabolism of substance P. Receptor affinity for tachykinins is: substance P, substance K, neuromedin K. (NCI)
C41022	Neoplastic_Plasma_Cells_Present_in_Bone_Marrow	Abnormal_Bone_Marrow_Test_Result	Neoplastic Plasma Cells Present in Bone Marrow
C41023	Tachykinin_Receptor-1	G_Protein-Coupled_Receptor	Tachykinin Receptor 1|NK-1 Receptor|NK1R|NKIR|Neurokinin 1 Receptor|SPR|Substance P Receptor|TAC1R|TACR1|Tachykinin 1 Receptor	Encoded by human TACR1 Gene (GPCR1 Family), 407-aa 46-kDa Tachykinin Receptor 1 is a receptor for the tachykinin neuropeptide substance P and an integral membrane protein with 7 hydrophobic transmembrane regions that probably associates with G proteins that activate a phosphatidylinositol-calcium second messenger system. TACR1 is also involved in mediation of phosphatidylinositol metabolism of substance P. Receptor affinity for tachykinins is: substance P, substance K, neuromedin K. (NCI)
C41024	Neoplastic_Plasma_Cells_Under_10_Percent_of_Bone_Marrow_Nucleated_Cells	Neoplastic_Plasma_Cells_Present_in_Bone_Marrow	Neoplastic Plasma Cells Under 10 Percent of Bone Marrow Nucleated Cells
C41025	PTH_Gene	Peptide_Hormone_Gene	PTH Gene|PTH|Parathyroid Hormone Gene	Human PTH Gene (Parathyroid Hormone Family) encodes secreted (parathyroid cells) 115-aa 13-kDa (precursor) Parathyroid Hormone. PTH elevates blood Ca2+ levels by dissolving the salts in bone and preventing renal excretion. PTH defects cause familial isolated hypoparathyroidism. (NCI)
C41026	Neoplastic_Plasma_Cells_Between_10_and_30_Percent_of_Bone_Marrow_Nucleated_Cells	Neoplastic_Plasma_Cells_More_than_10_Percent_of_Bone_Marrow_Nucleated_Cells	Neoplastic Plasma Cells Between 10 and 30 Percent of Bone Marrow Nucleated Cells
C41027	Parathyroid_Hormone	Peptide_Hormone	Parathyroid Hormone|PTH|Parathormone|Parathyrin	Encoded by human PTH Gene (Parathyroid Hormone Family), secreted (parathyroid cells) 115-aa 13-kDa (precursor) Parathyroid Hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing renal excretion. PTH defects cause familial isolated hypoparathyroidism. (NCI)
C41028	Neoplastic_Plasma_Cells_More_Than_30_Percent_of_Bone_Marrow_Nucleated_Cells	Neoplastic_Plasma_Cells_More_than_10_Percent_of_Bone_Marrow_Nucleated_Cells	Neoplastic Plasma Cells More than 30 Percent of Bone Marrow Nucleated Cells
C41029	Heparin_Binding_Growth_Factor	Growth_Factor	Heparin Binding Growth Factor	Exhibiting high affinity for heparin, Heparin-Binding Growth Factors (HBGF) control proliferation and differentiation of mesenchymal, epithelial, and neuroectodermal cells. Heparin may store some growth factors in the extracellular matrix, stabilize these proteins, and protect them. For some factors, heparin binding is essential to interact with receptors; it enhances the activity of some HBGF. Class 1 factors comprise acidic proteins, related to (acidic) aFGF. Class 2 factors comprise basic proteins, related to (basic) bFGF. HBGFs appear to be products of different genes; some may not be mitogenic or secreted. Current members include FGF-1, FGF-2, FGF-3, FGF-4, FGF-5, FGF-6, FGF-7, FGF-8, FGF-9, FGF-10, FGF-11, FGF-12, FGF-13, FGF-14, FGF-15, FGF-16, FGF-17, FGF-18, FGF-19, FGF-20, FGF-21, FGF-22, and FGF-23. (NCI)
C41030	Monoclonal_Paraproteinemia_Present_in_Lower_than_Myeloma_Levels	Monoclonal_Paraproteinemia	Monoclonal Paraproteinemia Present in Lower than Myeloma Levels
C41031	Neoplastic_Plasma_Cells_More_than_10_Percent_of_Bone_Marrow_Nucleated_Cells	Neoplastic_Plasma_Cells_Present_in_Bone_Marrow	Neoplastic Plasma Cells 10 Percent or More of Bone Marrow Nucleated Cells
C41032	Bone_Marrow-Homing_Plasma_Cell	Plasma_Cell	Bone Marrow-Homing Plasma Cell	A mature white blood cell, differentiated in the bone marrow, activated to preferentially migrate to the bone marrow.
C41033	SILV_Gene	Gene_with_Unknown_or_Unclassified_Function	SILV Gene|ME20|PMEL17|SI|SIL|SILV|Silver Homolog (Mouse) Gene|gp100	Expressed in melanocytes and melanomas, human SILV Gene (PMEL17/NMB Family) encodes 661-aa 70-kDa (precursor) Melanocyte Lineage-Specific Antigen gp100, a probable type I membrane protein containing a putative leader sequence, a potential membrane anchor segment, 5 potential N-glycosylation sites, high levels of serine and threonine, a PKD domain, and amino acid similarity to tyrosinase and CAS2 protein. PMEL17 cross reacts with antityrosinase antibodies and expression correlates with melanin content. The soluble ME20-S form is a probable proteolytic cleavage product. CD8 T lymphocytes recognize a noncontiguous spliced nonameric sequence of gp100 on melanoma cells. Splicing appears to occur by transpeptidation involving an acyl-enzyme intermediate. (NCI)
C41034	Neoplastic_Plasma_Cells_Less_than_20_Percent_of_Bone_Marrow_Nucleated_Cells	Neoplastic_Plasma_Cells_Present_in_Bone_Marrow	Neoplastic Plasma Cells Under 20 Percent of Bone Marrow Nucleated Cells
C41035	Neoplastic_Plasma_Cells_Between_20_and_50_Percent_of_Bone_Marrow_Nucleated_Cells	Neoplastic_Plasma_Cells_Present_in_Bone_Marrow	Neoplastic Plasma Cells Between 20 and 50 Percent of Bone Marrow Nucleated Cells
C41036	Neoplastic_Plasma_Cells_More_than_50_Percent_of_Bone_Marrow_Nucleated_Cells	Neoplastic_Plasma_Cells_Present_in_Bone_Marrow	Neoplastic Plasma Cells More than 50 Percent of Bone Marrow Nucleated Cells
C41037	Melanocyte_Lineage-Specific_Antigen-gp100	Protein_with_Unknown_or_Unclassified_Function	Melanocyte Lineage-Specific Antigen gp100|95 kDa Melanocyte-Specific Secreted Glycoprotein|ME20|ME20-M/ME20-S|ME20M/ME20S|Melanocyte Protein MEL17|Melanocyte Protein PMEL17|Melanoma-Associated ME20 Antigen|PMEL17|SI|SIL|SILV|Silver Homolog|Silver Like|gp100	Expressed in melanocytes and melanomas by human SILV Gene (PMEL17/NMB Family), 661-aa 70-kDa (precursor) Melanocyte Lineage-Specific Antigen gp100is a probable type I membrane protein containing a putative leader sequence, a potential membrane anchor segment, 5 potential N-glycosylation sites, high levels of serine and threonine, a PKD domain, and amino acid similarity to tyrosinase and CAS2 protein. PMEL17 cross reacts with antityrosinase antibodies and expression correlates with melanin content. The soluble ME20-S form is a probable proteolytic cleavage product. CD8 T lymphocytes recognize a noncontiguous spliced nonameric sequence of gp100 on melanoma cells. Splicing appears to occur by transpeptidation involving an acyl-enzyme intermediate. (NCI)
C41038	Riboadenylate_Transferase	RNA_Polymerase	Riboadenylate Transferase|Polynucleotide Adenylyltransferase	Nuclear or cytoplasmic human Riboadenylate Transferases (Poly A Polymerase Family) catalyze template-independent post-transcriptional extension of the 3 prime end of an RNA strand by nonspecific and CPSF/AAUAAA-dependent polyadenylation activity during eukaryotic mRNA maturation. The N-terminal region appears required for nonspecific polymerase activity, while the N- and C-termini are required for specific polymerase activity. Specificity may occur through C-terminus interaction with CPSF, regulated by phosphorylation. The poly(A) reaction involves endoribonucleolytic pre-RNA cleavage at the poly(A) site and synthesis of the poly(A) tail. (NCI)
C41039	Localized_Lesion	Lesion	Localized Lesion
C41040	Lytic_Lesion	Bone_Lesion|Radiologic_Finding	Lytic Bone Lesion
C41041	Solitary_Lytic_Metastatic_Lesion	Lytic_Metastatic_Lesion	Solitary Lytic Metastatic Bone Lesion
C41042	Immunoglobulin_Deposition	Deposit	Immunoglobulin Deposition
C41043	MMP1_Gene	Metalloproteinase_Gene	MMP1 Gene|CLG|Matrix Metalloproteinase 1 (Interstitial Collagenase) Gene	Human MMP1 Gene (M10A Peptidase Family) encodes 469-aa 54-kDa (precursor) secreted zinc- and calcium-binding Matrix Metalloproteinase-1, containing a hemopexin-like domain, an N-terminal catalytic domain, and a C-terminal substrate- and TIMP-binding domain. MMP1 undergoes autolytic cleavage to major forms 27-kDa (inactive) and 22-kDa (a collagenase activator). MMP1 preferentially cleaves interstitial collagens types I, II, and III at one site in the triple helical domain. MMP1 also cleaves collagens types VII and X and alpha-macroglobulins. (NCI)
C41044	Matrix_Metalloproteinase-1	Matrix_Metalloproteinase	Matrix Metalloproteinase-1|CLG|Fibroblast Collagenase|Interstitial Collagenase|MMP-1Fibroblast Collagenase|MMP1	Encoded by human MMP1 Gene (M10A Peptidase Family), 469-aa 54-kDa (precursor) secreted zinc- and calcium-binding Matrix Metalloproteinase-1 contains a hemopexin-like domain, an N-terminal catalytic domain, and a C-terminal substrate- and TIMP-binding domain. MMP1 undergoes autolytic cleavage to major forms 27-kDa (inactive) and 22-kDa (a collagenase activator). MMP1 preferentially cleaves interstitial collagens types I, II, and III at one site in the triple helical domain. MMP1 also cleaves collagens types VII and X and alpha-macroglobulins. (NCI)
C41045	MMP8_Gene	Metalloproteinase_Gene	MMP8 Gene|CLG1|HNC|MMP8|Matrix Metalloproteinase 8 (Neutrophil Collagenase) Gene|PMNL-CL	Expressed in neutrophils, human MMP8 Gene (M10A Peptidase Family) encodes 467-aa 53-kDa (precursor) zinc- and calcium-binding Matrix Metalloproteinase-8, containing a hemopexin-like domain and stored in secondary granules. Activated by autolytic cleavage, MMP8 degrades fibrillar type I, II, and III interstitial collagens by cleavage in the triple helical domain. (NCI)
C41046	Matrix_Metalloproteinase-8	Matrix_Metalloproteinase	Matrix Metalloproteinase-8|CLG1|HNC|MMP8|Neutrophil Collagenase|PMNL Collagenase|PMNL-CL	Expressed in neutrophils by human MMP8 Gene (M10A Peptidase Family), 467-aa 53-kDa (precursor) zinc- and calcium-binding Matrix Metalloproteinase-8 contains a hemopexin-like domain and is stored in secondary granules. Activated by autolytic cleavage, MMP8 degrades fibrillar type I, II, and III interstitial collagens by cleavage in the triple helical domain. (NCI)
C41047	Light_Chain_Deposition	Immunoglobulin_Deposition	Immunoglobulin Light Chain Deposition
C41048	Heavy_Chain_Deposition	Immunoglobulin_Deposition	Immunoglobulin Heavy Chain Deposition
C41049	MMP14_Gene	Metalloproteinase_Gene	MMP14 Gene|MMP-X1|MT1-MMP|MTMMP1|Matrix Metalloproteinase 14 (Membrane-Inserted) Gene	Expressed in colon, breast, head, and neck, human MMP14 Gene (M10A Peptidase/MT-MMP Subfamily) encodes 582-aa 66-kDa (precursor) Matrix Metalloproteinase-14, a potential type I membrane protein endopeptidase expressed at the cell surface that contains a hemopexin-like domain and may bind zinc and calcium ions. MMP14 activates MMP2 protein and progelatinase A by cleavage and hydrolyzes collagenase 3 and the aggrecan interglobular domain. MMP14 may trigger tumor cell invasion by activating progelatinase A on the cell surface. (NCI)
C41050	Matrix_Metalloproteinase-14	Matrix_Metalloproteinase	Matrix Metalloproteinase-14|MMP-X1|MMP14|MT1-MMP|MTMMP1|Matrix Metalloproteinase 14|Membrane-Inserted Matrix Metalloproteinase|Membrane-Type Matrix Metalloproteinase 1|Membrane-Type-1 Matrix Metalloproteinase	Expressed in colon, breast, head, and neck by human MMP14 Gene (M10A Peptidase/MT-MMP Subfamily), 582-aa 66-kDa (precursor) Matrix Metalloproteinase-14 is a potential type I membrane protein endopeptidase expressed at the cell surface that contains a hemopexin-like domain and may bind zinc and calcium ions. MMP14 activates MMP2 protein and progelatinase A by cleavage and hydrolyzes collagenase 3 and the aggrecan interglobular domain. MMP14 may trigger tumor cell invasion by activating progelatinase A on the cell surface. (NCI)
C41051	Solitary_Mass	Mass	Solitary Mass
C41052	MAGEA12_Gene	Gene_with_Unknown_or_Unclassified_Function	MAGEA12 Gene|MAGE12|Melanoma Antigen Family A, 12 Gene	Expressed only in normal testis, human MAGEA12 Gene (MAGE Family) encodes 314-aa 35-kDa MAGE-12 Antigen, a tumor-specific antigen of unknown function recognized by autologous cytolytic T lymphocytes and containing a MAGE domain. (NCI)
C41053	MAGE-12_Antigen	Protein_with_Unknown_or_Unclassified_Function	MAGE-12 Antigen|MAGE12|MAGEA12|Melanoma Antigen Family A 12	Expressed only in normal testis by human MAGEA12 Gene (MAGE Family), 314-aa 35-kDa MAGE-12 Antigen is a tumor-specific antigen of unknown function recognized by autologous cytolytic T lymphocytes and containing a MAGE domain. (NCI)
C41054	PGGT1B_Gene	Protein_Complex_Subunit_Gene	PGGT1B Gene|BGGI|GGTI|PGGT1B|Protein Geranylgeranyltransferase Type I, Beta Subunit Gene	Human PGGT1B Gene (Protein Prenyltransferase Beta Subunit Family) encodes 377-aa 42-kDa Protein Geranylgeranyltransferase Type I Beta Subunit of alpha-beta heterodimeric GGTase-I, an enzyme that transfers a geranylgeranyl moiety to the Cys of a C-terminal CAAX motif in candidate proteins as a means of membrane localization. The 48-kDa alpha subunit of GGTase-I is identical to the alpha subunit (FNTA) of Farnesyl Protein Transferase. Containing 4 PFTB repeats, the beta chain (PGGT1B) of GGTase-I is distinct from the beta subunit (FNTB) of Farnesyl Protein Transferase; FNTB and PGGT1B are catalytic for specific substrates. The mammalian counterpart of CDC43 (S. cerevisiae) and responsible for peptide binding, PGGT1B acts on Rac1, Rac2, Rap1A, and Rap1B. (NCI)
C41055	Protein_Geranylgeranyltransferase_Type-I_Beta_Subunit	Protein_Complex_Subunit	Protein Geranylgeranyltransferase Type I Beta Subunit|BGGI|GGTI|GGTase-I-Beta|Geranylgeranyl Transferase Type I Beta Subunit|PGGT1B|Type I Protein Geranyl-Geranyltransferase Beta Subunit	Encoded by human PGGT1B Gene (Protein Prenyltransferase Beta Subunit Family), 377-aa 42-kDa Protein Geranylgeranyltransferase Type I Beta Subunit is part of the alpha-beta heterodimeric GGTase-I, an enzyme that transfers a geranylgeranyl moiety to the Cys of a C-terminal CAAX motif in candidate proteins as a means of membrane localization. The 48-kDa alpha subunit of GGTase-I is identical to the alpha subunit (FNTA) of Farnesyl Protein Transferase. Containing 4 PFTB repeats, the beta chain (PGGT1B) of GGTase-I is distinct from the beta subunit (FNTB) of Farnesyl Protein Transferase; FNTB and PGGT1B are catalytic for specific substrates. The mammalian counterpart of CDC43 (S. cerevisiae) and responsible for peptide binding, PGGT1B acts on Rac1, Rac2, Rap1A, and Rap1B. (NCI)
C41056	Geranylgeranyl_Transferase	Protein_or_Riboprotein_Complex	Geranylgeranyl Transferase|GGTase-I|Geranylgeranyltransferase Type I	Alpha-beta heterodimeric human GGTase-I transfers a geranylgeranyl moiety to the Cys of a C-terminal CAAX motif in candidate proteins as a means of membrane localization. The conserved 48-kDa alpha subunit of GGTase-I is identical to the alpha subunit (FNTA) of Farnesyl Protein Transferase. The conserved 42-kDa Protein Geranylgeranyltransferase Type I Beta Subunit (PGGT1B Gene), containing 4 PFTB repeats, is distinct from the beta subunit (FNTB) of Farnesyl Protein Transferase; FNTB and PGGT1B are catalytic for specific substrates. The mammalian counterpart of CDC43 (S. cerevisiae) and responsible for peptide binding, PGGT1B acts on Rac1, Rac2, Rap1A, and Rap1B. Interacting with TGF-beta and Activin Type I receptors, FNTA is likely a key component of p21ras signaling, a farnesyltransferase substrate. (NCI)
C41057	Interleukin-12_Receptor_Beta	Protein_or_Riboprotein_Complex	Interleukin 12 Receptor Beta|High Affinity Interleukin 12 Receptor|High Affinity Interleukin 12 Receptor Beta|Interleukin 12 Receptor	Human high affinity Interleukin 12 Receptor Beta (Type I Cytokine Receptor 2 Family) is composed of Interleukin 12 Receptor Beta 1 Chain (IL12RB1 Gene) and Interleukin 12 Receptor Beta 2 Chain (IL12RB2 Gene), both type I transmembrane proteins involved in signal transduction and each containing 5 FNIII domains; a box 1 motif required for JAK interaction/activation; and a WSXWS motif for protein folding, intracellular transport, and cell-surface receptor binding. IL12RB1/2 activity appears to contribute to host defense mechanisms and the inflammatory response. Both IL12RB1 oligomers and IL12RB2 oligomers act as a low affinity IL12 receptor. (NCI)
C41058	Multipotent_Bone_Marrow_Stem_Cell	Bone_Marrow_Stem_Cell_with_Variable_Lineage_Potential|Multipotent_Stem_Cell	Multipotent Bone Marrow Stem Cell	A specialized, self-renewing cell in the bone marrow that has the capacity to differentiate into a cell with a particular function.
C41059	Bone_Marrow_Myeloid_Stem_Cell	Retired_Concepts	Bone Marrow Myeloid Stem Cell|Myeloid Progenitor Cell|Myeloid Progenitor Cells|Stem Cells, Myeloid	One of the two stem cells derived from HEMATOPOIETIC STEM CELLS - the other being the lymphoid progenitor cell. Derived from these myeloid progenitor cells are the ERYTHROID PROGENITOR CELLS and the MYELOID CELLS (MONOCYTES and GRANULOCYTES).
C41060	Bone_Marrow_Myeloid_Stem_Cell_with_Predominant_Neutrophil_Differentiation	Myeloid_Progenitor_Cell	Bone Marrow Stem Cell with Predominant Neutrophil Differentiation	A primitive, undifferentiated blood cell which can undergo division and usually gives rise to a white blood cell in the neutrophil lineage.
C41061	Bone_Marrow_Stem_Cell_at_the_Earliest_Stage_of_Myeloid_Differentiation	Myeloid_Progenitor_Cell	Bone Marrow Stem Cell at the Earliest Stage of Myeloid Differentiation	An undifferentiated cell which can undergo division and can give rise to any of the early stage myeloid cells.
C41063	Neoplastic_Myeloid_Cell	Abnormal_Myeloid_Cell|Leukemic_Cell	Neoplastic Myeloid Cell
C41064	Endocrine	Anatomy_Modifier	Endocrine|ENDO	Collective designation for those tissues capable of secreting hormones.
C41065	Locally	General_Modifier	Locally	To a restricted area (of the body).
C41066	Leukemic_Small_Lymphocyte_with_Clumped_Chromatin	Leukemic_Lymphocyte|Small_Lymphocyte_with_Clumped_Chromatin	Leukemic Small Lymphocyte with Clumped Chromatin
C41067	Whole_Blood	Blood_Sample	Whole Blood|WHBLOOD|whole blood	Blood that has not been separated into its various components; blood that has not been modified except for the addition of an anticoagulant.
C41068	Leukemic_Medium_Sized_Lymphocyte_with_Basophilic_Cytoplasm	Leukemic_Lymphocyte|Medium-Sized_Lymphocyte_with_Basophilic_Cytoplasm	Leukemic Medium-Sized B-Lymphocyte with Basophilic Cytoplasm
C41069	Leukemic_Hematopoietic_Stem_Cell	Clonal_Hematopoietic_Stem_Cell|Leukemic_Cell	Leukemic Hematopoietic Stem Cell
C41070	Leukemic_Natural_Killer_Cell	Leukemic_Lymphocyte|Neoplastic_Natural_Killer-Cell	Leukemic Natural Killer Cell
C41071	Leukemic_Plasma_Cell	Leukemic_Lymphocyte|Neoplastic_Plasma_Cell	Leukemic Plasma Cell
C41072	Coronary	Anatomy_Modifier	Coronary|COR	Surrounding like a crown (especially of the blood vessels surrounding the heart).
C41073	Leukemic_Lymphocyte	Leukemic_Cell|Neoplastic_Lymphocyte	Leukemic Lymphocyte
C41074	EVI1-AML1_Fusion_Protein_Expression	Fusion_Protein_Expression	EVI1-AML1 Fusion Protein Expression
C41075	Implant	Prosthesis	Implant|IMPL	A prosthesis placed permanently in tissue.
C41077	Date_Available	UML_Entity	Date Available|Availablibility	Dates on which an animal model record was entered, modified or release to the intended viewing audience.
C41078	Carcinogenic_Intervention	UML_Entity	Carcinogenic Intervention	Treatment or procedure that the animal model was exposed to in order to initiate or support the development of neoplastic lesions.
C41079	Classification_Scheme	UML_Entity	Classification Scheme	An arrangement or division of objects into groups based on characteristics that the objects have in common, e.g., origin, composition, structure, application, function, etc. Adds information not easily included in definitions, helps organize the registry and facilitates access to the registry.
C41080	Classification_Scheme_Item	UML_Entity	Classification Scheme Item	A component of content in a Classification Scheme. This may be a node in a taxonomy or ontology or a term in a thesaurus, etc.
C41081	Class_Scheme_Class_Scheme_Item	UML_Entity	Class Scheme Class Scheme Item	This builds the relationships between Classification Schemes and Classification Scheme Items.
C41082	CMAP_Ontology_ID	UML_Entity	CMAP Ontology ID	An object providing entry to the CMAP gene ontology.
C41083	Conceptual_Domain	UML_Entity	Conceptual Domain	The set of all possible Valid Value meanings of a Data Element Concept expressed without representation.
C41084	Transgene_Conditionality	UML_Entity	Transgene Conditionality|Conditionality	Indicates if a transgene or targeted modification is done conditionally (time or tissue specific).
C41085	Contact_Info	Information	Contact Info	Information regarding the person who is acting as a channel for communication between groups.
C41086	Application_Context	UML_Entity	Application Context|Context	A designation or description of the application environment or discipline in which a name is applied or from which it originates.
C41087	Data_Element_Concept	UML_Entity	Data Element Concept	A concept that can be represented in the form of a data element, described independently of any particular representation. (ISO 11179)
C41088	Data_Element_Concept_Relationships	Retired_Concepts	Data Element Concept Relationships	A description of the affiliation between two occurrences of Data Element Concepts.
C41089	Data_Element_Derivation	UML_Entity	Data Element Derivation	The data element component(s) used for a derived data element.
C41090	Derivation_Type	UML_Entity	Derivation Type	The type of Derived Data Element that is being created. For example a Data Element that is derived/created by subtracting two dates represented by other data elements would be a Calculated Representation Type. Types include: Calculated, Complex Recode, Compound, Concatenation, Object Class, and Simple Recode.
C41091	Derived_Data_Element	UML_Entity	Derived Data Element	The Data Element that is derived from one or more data elements. ISO DEF: the relationship among a Data Element which is derived, the rule controlling its derivation, and the Data Element(s) from which it is derived.
C41092	Administered_Component_Designation	UML_Entity	Administered Component Designation|Designation	A name by which an Administered Component is known in a specific Context. Also a placeholder to track the usage of Administered Components by different Contexts.
C41093	Expression_Measurement_Object	UML_Entity	Expression Measurement Object|Expression Measurement	An object representing a structure that is capable of measuring the absolute or relative amount of a given compound.
C41094	Expression_Measurement_Array	UML_Entity	Expression Measurement Array	An array of expression measurement objects.
C41095	Gene_Alias	UML_Entity	Gene Alias	This object describes the gene alias.
C41096	Gene_Delivery	UML_Entity	Gene Delivery	Gene is delivered to specific organs or specific receptors within the animal model using viral vectors.
C41097	Genomic_Segment	UML_Entity	Genomic Segment	Genomic segment extracted from a library e.g. BAC or YAC library to be used in the genetic manipulation of the animal model.
C41098	Genotype_Summary	UML_Entity	Genotype Summary	Listing of the genetic changes made deliberately in order to generate the animal model.
C41099	Integration_Type	UML_Entity	Integration Type|Location of Integration	Location of the integration of the engineered gene e.g. random or targeted.
C41100	Invivo_Result	UML_Entity	In vivo Result|Invivo Result	An Invivo Result captures the results of anti-tumor drug screening.
C41101	Jax_Info	UML_Entity	Jax Info|Jax Stock Number	Identification number (stock number) of strain at the Jackson Laboratory.
C41102	Micro_Array_Data	Retired_Concepts	Microarray Data|Micro Array Data	Data of microarray experiments generated from the animal model.
C41103	Modification_Type	Retired_Concepts	Modification Type
C41104	Data_Element_Module	UML_Entity	Data Element Module	A collection of data elements, or Common Data Elements, logically grouped on a case report form.
C41105	Rodent_Nomenclature_Name	UML_Entity	Rodent Nomenclature Name|Nomenclature	Official nomenclature name for mouse and rat models.
C41106	Object_Class	UML_Entity	Object Class|Object	A set of ideas, abstractions, or things in the real world that can be identified with explicit boundaries and meaning and whose properties and behavior follow the same rules. (ISO 11179)
C41107	Party_Name	UML_Entity	Party|Party Name	An informal term specifying an organization or person.
C41108	Party_Role	UML_Entity	Party Role	This object connects the party (organization or person) with the animal model.
C41109	Permissible_Value	UML_Entity	Permissible Value	The exact names, codes and text that can be stored in a data field in an information management system.
C41110	EVS_Concept_Property	UML_Entity	EVS Concept Property|Property	This class encapsulates the name value properties of EVS Concept object. (NCI-SC)
C41111	Library_Protocol	Protocol_Generic_Term	Library Protocol|Protocol	Laboratory protocol used to prepare a Library.
C41112	Protocol_Association	UML_Entity	Protocol Association	An association class relating between Clinical Trial Protocols to Diseases.
C41113	Protocol_Forms_Set	UML_Entity	Protocol Forms Set	Protocols, with Case Report Forms included, stipulate the execution of Clinical Trials.
C41114	Protocol_Forms_Template	UML_Entity	Protocol Forms Template	The description and the values of the components comprising Case Report forms.
C41115	Publication_Status	Retired_Concepts	Publication Status	Status of the publication e.g. published, submitted.
C41116	Question_Text	UML_Entity	Question Text|Question	The actual text of the data element as specified on a Case Report Form of a Protocol.
C41117	Reference_Document	Document_Type	Reference Document	A document that provides pertinent details for consultation about a subject. (ISO 11179)
C41118	Regulatory_Element_Type	Retired_Concepts	Regulatory Element Type	Type of the regulatory element e.g. promoter, polyA signal.
C41119	Repository_Info	UML_Entity	Repository Info	An object that contains information about the availability of a particular model from the repository. A submitter of data to the cancer models database can also indicate if their model should be submitted to the repository.
C41120	Representation_Component	UML_Entity	Representation Component|Representation	Mechanism by which the functional and/or presentational category of an item may be conveyed to a user. Component of a Data Element Name that describes how data are represented (i.e. the combination of a Value Domain, data type, and if necessary a unit of measure or a character set.) The Representation occupies the last position in the Data Element name (i.e. rightmost).
C41121	Screening_Result	UML_Entity	Screening Result	A Screening Result captures the results of the tens of thousands of compounds screened for their ability to inhibit the growth of selected yeast strains altered in DNA damage repair or cell cycle control.
C41122	Segment_Type	Retired_Concepts	Segment Type	Specifies the type of library that the genomic segment was retrieved from such as BAC or YAC.
C41123	Tumor_Code	Retired_Concepts	Tumor Code	A tumor code captures the tumor type and origin species used for a drug screen test.
C41124	Valid_Value	UML_Entity	Valid Value	The allowable values for a given data element (question) on a Case Report Form.
C41125	Value_Domain_Permissible_Value	UML_Entity	Value Domain Permissible Value	This captures the many to many relationship between value domain and permissible values and allows to associate a value domain to a permissible value.
C41126	Value_Meaning	UML_Entity	Value Meaning	The significance associated with an allowable/permissible value.
C41127	Dalton	Unit_of_Mass	Dalton|Da	A non-SI unit of mass equivalent of the weight of a hydrogen atom or one-sixteenth of mass of oxygen atom, or 1.657 x 10(e-24) grams. Proteins and other macromolecule molecular weights are usually measured in kilodaltons (kDa or kD). Named for British chemist John Dalton who proposed the atomic theory of the matter.
C41128	Dermatologic	Properties_or_Attributes	Dermatologic	Having to do with the skin, relating to or practicing dermatology.
C41129	Region	Properties_or_Attributes	Region	An area or portion of something such as the surface of the body, the land surface, or part of the world, with more or less definite boundaries designed according to some established biological, administrative, economic, demographic, etc. criteria.
C41130	Significant	General_Modifier	Significant	A term applied to differences, correlations, cause-and-effect relationships, etc., to indicate that they are noticeable, probably too closely correlated to be attributed to chance and therefore indicating a systematic relation: substantial, fairly large; also having consequence or import, important in effect or meaning. In statistics significant ordinarily indicates a probability of not less than 95 percent, while highly significant indicates a probability of not less than 99 percent.
C41132	None	General_Modifier	None	No person or thing, nobody, not any.
C41133	Healed	Disease_Modifier	Healed	Recovered, restored to healthy condition by natural processes, e.g. by scar formation; freed from illness or injury.
C41134	Today	Temporal_Modifier	Today	The day that includes the present moment, as distinct from yesterday or tomorrow.
C41135	Birth_Weight	Retired_Concepts	Birth Weight	In humans, the weight of a neonate measured within one hour after birth. The factors influencing the birth weight include but not limited to infant sex, racial and ethnic group, maternal size and health status, concurrent diseases, parity, and nutrition, pregnancy environment and conditions, e.g. altitude of geographic area.
C41136	Dental	Anatomy_Modifier	Dental	Pertaining to a tooth or teeth, or to odontology.
C41137	Amyloidoma	Amyloidosis	Amyloidoma|Nodular Amyloidosis	Amyloidoma - nodular localized form of amyloidosis with predominantly thoracic localization (pulmonary amyloidosis), considered as secondary protein structure diseases in which insoluble protein fibrils accumulate extracellularly. The form of primary amyloid in amyloidoma is characterized by abnormal deposition of light chain proteins composed of monoclonal immunoglobulin. Pulmonary amyloidomas are rare and are often found incidentally as solitary or multiple calcified nodules and masses on chest radiographs in asymptomatic elderly patients. Cavitation is rare, the prognosis is good.
C41139	Meter	Base_Unit_of_International_System_of_Units|Unit_of_Length	Meter|Metr|Metras|Metre|Metri|Metro|m	The unit of linear measure in the metric system, one of the seven base units of the International System of Units (Systeme International d'Unites, SI). Meter is defined as the length of the path traveled by light in a vacuum during a time interval of 1/299 792 458 of a second and is equal to 1.093 61 yards.
C41140	Millisecond	Unit_of_Time	Millisecond|Msec|ms	A unit of time, which is equal to one thousandth of a second.
C41141	Flow	Physical_Phenomena_or_Properties	Flow	The continuous movement characteristic of a liquid or gas.
C41142	Fahrenheit_Scale	Properties_or_Attributes	Fahrenheit Scale	A thermometric scale named after the German physicist Gabriel Fahrenheit, on which under standard atmospheric pressure the boiling point of water is at 212 degrees above the zero of the scale, the freezing point is at 32 degrees above zero, and the zero point approximates the temperature produced by mixing equal quantities by weight of snow and common salt. The scale is used by the general population of USA and Jamaica for non-scientific temperature measurement.
C41144	Texture	Physical_Phenomena_or_Properties	Texture	A measure of the variation of the intensity of a surface, quantifying properties such as smoothness, coarseness, regularity, and resiliency. The term is often used as a descriptor for the structure or organization of a tissue or organ. The three principal approaches used to describe texture are statistical, structural and spectral.
C41145	Thickness	Characteristics	Thickness	The dimension between two surfaces of an object, usually the smallest dimension as opposed to the width or the length: also, viscous consistency.
C41146	Speed	Characteristics	Speed	A scalar measure of the rate of movement of the object expressed either as the distance travelled divided by the time taken (average speed) or the rate of change of position with respect to time at a particular point (instantaneous speed).
C41147	Modality	Characteristics	Modality	A specific manner, characteristic, pattern of application or the employment of, any therapeutic agent or method of treatment, especially involving the physical treatment of a condition.
C41148	Placement	Properties_or_Attributes	Placement	Position or arrangement, as of the teeth; the state of being placed or arranged, as the assignment of a person to a appropriate clinical study.
C41149	Spatial_Design	Properties_or_Attributes	Spatial Design	Spatial design refers to the ways in which objects or bodies are placed in space.
C41150	Income	Socioeconomic_Factors	Income	A gain or recurrent benefit during a period of time, usually measured in money that derives from capital or labor. Income is one of the major demographic parameters used in population-based biomedical research.
C41151	Celsius_Scale	Properties_or_Attributes	Celsius Scale|Celsius	The temperature scale defined by the values 0 degree Celsius for the freezing point of water and 100 degrees Celsius for the boiling point of water.  The Celsius degree (C) is the same size as a Kelvin and equal to (F - 32)/1.8.
C41152	Indigenous	Personal_Attribute	Indigenous	A person who belongs naturally to a place in the sense of long-term family origins. The term is used specifically to refer to aboriginal populations, e.g. Aborigine in Australia; as well as to identify the majority population, e.g. in the UK it is an alternative to the White.
C41161	Protocol_Agent	UML_Entity	Protocol Agent|Agent	A therapeutic agent (drug, intervention therapy) used in a clinical trial protocol.
C41162	Animal_Cancer_Model	Animal_Model	Animal Cancer Model	An animal model which develops cancer or can be used to generate a model that develops cancer.
C41163	IMAGE_Clone_Object	Retired_Concepts	IMAGE Clone Object|Clone|IMAGE Clone	I.M.A.G.E. clone object; provides access to sequence, associated trace files and the clone's source library.
C41164	Expression_Feature	UML_Entity	Expression Feature	Describes the expression pattern of a gene.
C41165	Hematopoietic_and_Lymphatic_System	Organ_System	Hematopoietic and Lymphatic System
C41166	Hematopoietic_and_Lymphatic_System_Part	Body_Part	Hematopoietic and Lymphatic System Part
C41167	Organizational_Unit	UML_Entity	Organizational Unit|Organization	Organizational unit like a laboratory, institute or consortium.
C41168	Hematopoietic_and_Lymphoid_Tissue	Tissue	Hematopoietic and Lymphoid Tissue
C41169	GO_Ontology_Object	UML_Entity	GO Ontology Object|GO Ontology	An object providing entry to a Gene object's position in the Gene Ontology Consortium's controlled vocabularies.
C41170	Gene_Function_Object	Retired_Concepts	Gene Function Object|Gene Function	Functions of the engineered genes.
C41171	Person_Info	UML_Entity	Person Info|Person	Person's first and last name and the connection to the party.
C41172	Protein_Info	UML_Entity	Protein Info|Protein	Protein; provides access to the encoding gene via its GenBank Accession, the taxon in which this instance of the protein occurs, and references to homologous proteins in other species.
C41173	SNP_Info	UML_Entity	SNP Info|SNP	Provides access to the clones and the trace files from which it was identified, the two most common substitutions at that position, the offset of the SNP in the parent sequence, and a confidence score.
C41174	Therapy_Object	UML_Entity	Therapy Object|Therapy	Pre-clinical trials experiment conducted on the animal model with the goal to reduce cancer burden.
C41175	Map_Location_Object	UML_Entity	Map Location Object|Map Location	Physical map location of a Gene, expressed as either a cytological chromosomal band or by chromosome, start point and end point.
C41176	Immature_Granulocytes_in_Peripheral_Blood_Under_10_Percent	Abnormal_Hematology_Test_Result	Immature Granulocytes in Peripheral Blood Under 10 Percent
C41177	Eosinophil_Precursor_Cell	Myeloid_Cell	Eosinophil Precursor Cell
C41178	Clonal_Eosinophils_Present	Clonal_Cellular_Population_Present	Monoclonal Eosinophils Present|Clonal Eosinophils Present
C41179	Clonal_Cellular_Population_Present	Abnormal_Laboratory_Test	Monoclonal Cellular Population Present|Clonal Cellular Population Present
C41184	Indication	Conceptual_Entities	Indication	A sign, signal, circumstance, or symptom which serves to indicate or point out the cause, pathology, treatment, or issue of an attack of disease; the basis for initiation of a treatment for a disease or of a diagnostic test (causal, or symptomatic, or disease-specific indication).
C41185	Concentration	Characteristics	Concentration	The quantity of a substance per unit volume or weight; a measure of the amount of substance present in a unit amount of mixture, particularly, the amount of solute dissolved in a solvent. The amounts can be expressed as moles, masses, volumes, or parts.
C41186	Structure	Conceptual_Entities	Structure	The components and their relationship and manner of arrangement in constituting a whole.
C41187	Preference	Conceptual_Entities	Preference	The act, fact, or principle of giving advantages to some particular person, object, or course of action over others.
C41188	Consult	Clinical_or_Research_Activity	Consult	To consult is the act to deliberate together, to confer with another researcher, physician about an issue, or a case; to look to for advice or information.
C41189	Study_Subject	Conceptual_Entities	Study Subject|Subject	A matter or person that is analyzed, examined, investigated, experimented upon, or treated in the course of particular study.
C41190	Diversion_Program	Behavioral_Intervention	Diversion Program	Diversion program is the type of program designed to assist individuals and families to address diverse issues such as alcohol and drug abuse, child disobedience, behavioral deviations, misdemeanor and felony. Essential components of the program include but are not limited to: information and referral, case management, advocacy, short term support, help in identifying and assessing the services most appropriate to meet the needs of the individual and family. The program helps to guide each individual towards a positive understanding, acceptance and change of the problems at hand whereby the health and safety of the public is maintained.
C41191	Reporter	Research_Personnel	Reporter	Somebody who makes a report of any kind, e.g. a person who is authorized to gather and give a formal or official account or description of findings, events, issues and other information regarding clinical study, drug adverse effect, preclinical research results, data and safety monitoring, etc. to appropriate agency or institution.
C41192	Authorization	Document_Type	Authorization|Allowance|Permission	Decision of the competent authorities in form of a letter, document, or verbal or electronic form, that confirms that somebody has permission to do something or be somewhere, e.g. to realize a given project.
C41193	Olfactory_Learning	Animal_Model	Olfactory Learning	A model used in behavioral neuroscience to study behavioral processes and plasticity, memory, learning and perceptual processes and underlying neural mechanisms such as the cellular changes and modulations in sensory transduction and their evolutionary control. The model uses odorant conditioned stimuli temporally paired with unconditioned stimuli to produce conditioned responses to the odorant. Learned behaviors include conditioned behavioral activation and approach responses to the conditioned stimulus odor. The model is effective in diverse range of laboratory species such as honeybees, worms, flies, rats, and canines.
C41194	Household	Social_Group	Household	A social unit comprised of one or more individuals living together (all of whom need not be related) in the same dwelling, who aggregate and share their incomes. Household is a common unit for classifying population data.
C41195	Equation	Conceptual_Entities	Equation	A statement written in symbols that two objects, e.g. mathematical expressions, or arrays of symbols representing a chemical reaction, are equal under certain conditions. Equations are usually and sometimes tacitly accompanied by the requirement to establish these conditions. In the case where mathematical or chemical objects contain arbitrary variables, such a requirement may mean finding those values of the variables that turn the equation into equality. Equations are sometimes called more explicitly as conditional equations.
C41196	Citation	Conceptual_Entities	Citation	An extract or quotation from or reference to an authoritative source, e.g. a book or author, used, for example, to support an idea, theory, or argument.
C41198	Investigation	Clinical_or_Research_Activity	Investigation	The act or process of a systematic and thorough examination; research, study; the process of inquiring into or following up, intended to develop facts.
C41199	Filter	Diagnostic_Therapeutic_and_Research_Equipment	Filter	A device that removes something from whatever passes through it.
C41200	Amendment	Document_Type	Amendment	A change in a document made by correction, adding, substituting or omitting a certain part. Amendments are the mechanism of changes introduction, further development and improvement of previously submitted or approved clinical study protocols and proposals.
C41201	Monitor	Miscellaneous_Occupations	Monitor	An individual who over a period of time checks on and maintains continuous observation of state, condition, situation, or process as a check on output, efficiency, incorrect conduct etc. and warns of faults, or gives advice and instruction by way of reporting or caution.
C41202	Completion_Status	Business_Rules	Completion Status	A term used to describe the workflow progression of a document or the state of the project or activity in term of being finished, concluded, or made whole.
C41203	Label	Pharmaceutical_Product_Information	Pharmaceutical Product Label|Drug Label|Label	A written, printed, or graphic matter upon the immediate container of any substance or device to identify something and to indicate the nature, ownership, contents and other characteristic particulars of the object. FDA and the Supreme Court have stated that labeling is to be interpreted liberally, and includes not only that which accompanies an article but also that which spiritually accompanies an article as well as supplements. Drug label must include: trademark and category of product, description of product chemical and physical characteristics, clinical pharmacology, pharmacokinetics, data on absorption, distribution, metabolism and excretion, special populations, clinical studies, efficacy and safety data, indications, contraindications, adverse events warnings and precautions including lab tests; potential drug interactions, carcinogens statement, pregnancy category.
C41204	Need	Conceptual_Entities	Need|Needs	Anything that is necessary but lacking; the psychological feature that arouses an organism to action toward a desired goal; the reason for the action; that which gives purpose and direction to behavior.
C41205	Disposition	Conceptual_Entities	Disposition	Disposition - the tendency of something to act in a certain manner under given circumstances resulting from natural constitution; nature; quality; orderly arrangement.
C41206	Institution	Professional_Organization_or_Group	Institution|Institute	An established society, corporation, foundation or other organization founded and united for a specific purpose, e.g. for health-related research as, a literary institution; also, a building or the buildings occupied or used by such organization.
C41207	Chain	Conceptual_Entities	Chain	A series of objects linked, connected, or associated together in linear fashion (e.g., the assemblage of atoms, radicals and chemical groups in a chemical compound, or an assemblage of individual microorganisms).
C41208	Compression	Conceptual_Entities	Compression	The act, process, or result of pressing together, flattening, or condensing, particularly, increasing an external physical pressure on a body structure. Also refers to the reduction in the volume of a body or substance and augmentation of its density due to pressure.
C41209	Attention_Concentration	Mental_Process	Attention Concentration	The act or process of concentrating, focusing the undivided attention and mental energy on a single object. MeSH: Focusing on certain aspects of current experience to the exclusion of others. It is the act of heeding or taking notice or concentrating.
C41210	Stimulus	Conceptual_Entities	Stimulus|Stimuli	An environmental event, agent, act, or influence that can be detected by a receptor in the body and will invariably produce a reaction in a living organism, e.g. change in the behavior, functional or trophic reaction.
C41211	Positive_Reinforcer	Stimulus	Positive Reinforcer	A stimulus that increases the frequency of behavior that leads to its presentation. Things such as food, water, sex, and the opportunity to explore are usually considered as positive reinforcers. Also many dependence-producing drugs, such as cocaine, morphine, phencyclidine, barbiturates, ethanol and some volatile solvents serve as a positive reinforcer.
C41212	Negative_Reinforcer	Stimulus	Negative Reinforcer	A stimulus that increases the frequency of a behavior that prevents or terminates its presentation. Noxious stimuli, such as shock in laboratory animal experiments, are considered to be negative reinforcers.
C41215	Pavlovian_Conditioning	Conditioning	Pavlovian Conditioning	A classical conditioning procedures that present different stimuli in temporal proximity (contiguity), but where resulting responses have no reinforcing or aversive consequences. Named after the author of the experiments (Dr. I. Pavlov) in which dogs were conditioned to salivate at the sound of a tone.
C41216	Addendum	Document_Type	Addendum	An appendage to an existing document that contains supplemental information. The parent document remains content is unaltered.
C41219	Native_Hawaiian_or_Other_Pacific_Islander	Race	Native Hawaiian or Other Pacific Islander	A person having origins in any of the original peoples of Hawaii, Guam, Samoa, or other Pacific Islands. The term covers particularly people who identify themselves as part-Hawaiian, Native Hawaiian, Guamanian or Chamorro, Carolinian, Samoan, Chuukese (Trukese), Fijian, Kosraean, Melanesian, Micronesian, Northern Mariana Islander, Palauan, Papua New Guinean, Pohnpeian, Polynesian, Solomon Islander, Tahitian, Tokelauan, Tongan, Yapese, or Pacific Islander, not specified.
C41221	Ethnicity_not_Reported	Retired_Concepts	Ethnicity not Reported	Ethnicity not reported record means that data on ethnicity is not provided or available.
C41222	Not_Hispanic_or_Latino	Ethnic_Group	Not Hispanic or Latino|Non-Hispanic|Non-Hispanic or Latino	A person not of Cuban, Mexican, Puerto Rican, South or Central American, or other Spanish culture or origin, regardless of race. An arbitrary ethnic classification.
C41226	African_Caribbean	Race	African Caribbean	A person of African ancestral origins whose family settled in the Caribbean region.
C41227	Surgical_Margin	Diagnostic_or_Prognostic_Factor	Surgical Margin|Surgical Margins|margin	The edge or border of the tissue removed in cancer surgery.  The margin is described as negative or clean when the pathologist finds no cancer cells at the edge of the tissue, suggesting that all of the cancer has been removed.  The margin is described as positive or involved when the pathologist finds cancer cells at the edge of the tissue, suggesting that all of the cancer has not been removed.
C41228	IL13RA1_Gene	Cytokine_Receptor_Gene	IL13RA1 Gene|IL-13Ra|IL13RA1|Interleukin 13 Receptor, Alpha 1 Gene|NR4	The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. (from LocusLink RefSeq)
C41229	Xq24	Chromosome_Band	Xq24	A chromosome band present on Xq
C41230	Interleukin-13_Receptor_Alpha_1	Cytokine_Receptor	Interleukin-13 Receptor Alpha 1|CD213a1 Antigen|IL13RA1|Interleukin-13 Receptor Alpha	This protein is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. (from LocusLink RefSeq)
C41231	Charcot-Leyden_Crystal_Formation	Crystal_Formation	Charcot-Leyden Crystals Formation
C41232	Polycythemia_Vera_Polycythemic_Stage	Polycythemia_Vera	Polycythemia Vera, Polycythemic Stage
C41233	Polycythemia_Vera_Post-Polycythemic_Myelofibrosis_and_Myeloid_Metaplasia_Phase	Polycythemia_Vera	Polycythemia Vera, Post-Polycythemic Myelofibrosis and Myeloid Metaplasia Stage|Polycythemia Vera, "Spent" Phase
C41234	Increased_Red_Cell_Mass	Abnormal_Blood_and_Hematology_Test_Result	Increased Red Cell Mass
C41235	Extramedullary_Hematopoiesis	Morphologic_Finding	Extramedullary Hematopoiesis
C41236	Osteosclerosis	Morphologic_Finding	Osteosclerosis
C41237	Chronic_Idiopathic_Myelofibrosis_Prefibrotic_Stage	Chronic_Idiopathic_Myelofibrosis	Chronic Idiopathic Myelofibrosis, Prefibrotic Stage|Chronic Idiopathic Myelofibrosis, Cellular Phase
C41238	Chronic_Idiopathic_Myelofibrosis_Fibrotic_Stage	Chronic_Idiopathic_Myelofibrosis	Chronic Idiopathic Myelofibrosis, Fibrotic Stage
C41239	Minimal_Reticulin_Fibrosis_of_the_Bone_Marrow	Reticulin_Fibrosis_of_the_Bone_Marrow	Minimal Reticulin Fibrosis of the Bone Marrow
C41240	Marked_Bone_Marrow_Fibrosis	Bone_Marrow_Fibrosis	Marked Bone Marrow Fibrosis
C41241	Blasts_Under_10_Percent_of_Peripheral_Blood_White_Cells	Blasts_Under_20_Percent_of_Peripheral_Blood_White_Cells	Blasts Under 10 Percent of Peripheral Blood White Cells
C41242	Granulocytes_Increased_in_Bone_Marrow	Immature_Myeloid_Cells_Increased_in_Bone_Marrow	Granulocytes Increased in Bone Marrow
C41243	NSC_Code	Code	NSC Code|Nomenclature Standards Committee Code	A unique drug identifier issued by the Nomenclature Standards Committee of the U.S. Food and Drug Administration.
C41244	NSC_Generic_Product_Identifier	NSC_Code	NSC Generic Product Identifier|NSC/GPI|Nomenclature Standards Committee Generic Product Identifier	An NSC code identifier issued for a generic product.
C41245	Pancreatic_Non-Invasive_Mucinous_Cystadenocarcinoma	Pancreatic_Mucinous_Cystadenocarcinoma	Pancreatic Non-Invasive Mucinous Cystadenocarcinoma
C41246	Pancreatic_Invasive_Mucinous_Cystadenocarcinoma	Pancreatic_Mucinous_Cystadenocarcinoma	Pancreatic Invasive Mucinous Cystadenocarcinoma
C41247	Pancreatic_Mucinous_Cystic_Neoplasm	Exocrine_Pancreas_Neoplasm|Mucinous_Neoplasm	Pancreatic Mucinous Cystic Neoplasm
C41248	Pancreatic_Serous_Cystic_Neoplasm	Exocrine_Pancreas_Neoplasm|Serous_Neoplasm	Pancreatic Serous Cystic Neoplasm
C41249	Pancreatic_Intraductal_Papillary-Mucinous_Adenoma	Benign_Exocrine_Pancreatic_Neoplasm|Pancreatic_Intraductal_Papillary-Mucinous_Neoplasm	Pancreatic Intraductal Papillary-Mucinous Adenoma
C41251	Pancreatic_Non-Invasive_Intraductal_Papillary-Mucinous_Carcinoma	Pancreatic_Intraductal_Papillary-Mucinous_Carcinoma	Pancreatic Non-Invasive Intraductal Papillary-Mucinous Carcinoma
C41253	Zinc_Finger_Protein-265	Transcription_Factor	Zinc Finger Protein-265|Zis-Protein-265	A product of a developmentally regulated gene expressed in differentiated renal myoepithelioid juxtaglomerular cells located in the afferent arteriole at the entrance to the glomerulus. Their main function and distinctive feature is the synthesis and release of renin, the key hormone-enzyme of the renin-angiotensin system that regulates arterial blood pressure. Zis protein reveals transcription factor activity and was shown to contain zinc fingers and domains characteristic of splicing factors and RNA binding proteins.
C41254	DNA_Resequencing	Nucleic_Acid_Sequencing	DNA Resequencing|Resequencing	A specific application of gene sequencing that precisely determines the sequence of bases in DNA. Resequencing is used to identify single nucleotide polymorphisms (SNPs).
C41255	Interpretation	Mental_Process	Interpretation	An act or process of elucidation; explication, or explanation of the meaning of the event or thing via the assignment of objects from the domain to the constants of a formal language, truth-values to the proposition symbols, truth-functions to the connectives, other functions to the function symbols, and extensions to the predicates, if any. The assignments are result of human logic application and are not native to the symbols of the formal language. Examples of interpretation include rendering by the psychotherapist the latent or hidden meaning of what the patient says, does, or experiences in understandable to him format; the conception of another's behavior; the establishment of significance of something; the result of EKG tracing reading.
C41256	Family_Member	Member	Family Member	A member of the fundamental unit of society designed primarily to regulate sexual behavior and reproduce, nurture, protect, and socialize the youngs, traditionally organized around kinship ties, descend from the common progenitor or related by marriage or by a feeling of closeness; or of any of various social units differing from but regarded as equivalent to the traditional family.
C41257	Aversive_Stimulus	Stimulus	Aversive Stimulus|Aversive Stimuli	A stimulus causing an organism to behave so as to minimize exposure to it (as in negative reinforcement or punishment procedures).
C41258	Conditioning	Conceptual_Entities	Conditioning	Generally refers to relative simple learning situations in which a stimulus initially incapable of evoking a certain response acquires the ability to do so by repeated pairing with another stimulus that does elicit the response.
C41259	American_Indian_or_Alaska_Native	Race|Underrepresented_Minority	American Indian or Alaska Native|First Nations|Native American|Native Americans	A person having origins in one of the indigenous peoples of North America, who lived on the continent prior to the European colonization. The term includes individuals belonging to a large number of tribes, states, and ethnic groups, many of them still enduring as communities.
C41260	Asian	Race	Asian|Asians	A person having origins in any of the original peoples of the Far East, Southeast Asia, or the Indian subcontinent, including Cambodia, China, India, Japan, Korea, Malaysia, Mongolia, Pakistan, the Philippine Islands, Thailand, and Vietnam.
C41261	White	Race	White|Caucasian|Caucasians|Caucasoid|Occidental|Whites	A person with European, Middle Eastern, or North African ancestral origin who identifies, or is identified, as White.
C41262	Asian_Indian	South_Asian	Asian Indian|Asian Indians|Hindu	A person having origins in the original peoples of the Indian sub-continent. In North America the term is used to distinguish this population group from Native Americans. The concept is close to the term South Asian but several major South Asian populations such as Pakistani and Bangladeshi may not identify with it.
C41263	South_Asian	Asian	South Asian|South Asians	A person whose ancestry is in the countries of the Indian sub-continent, including India, Pakistan, Bangladesh, and Sri Lanka.
C41264	Serological	General_Modifier	Serological|Serologic	Pertaining to the in vitro reactions and properties of immune sera, particularly, the concept refers to the use of such reactions to measure serum titers of antibody against infectious and non-infectious agents (serologic tests), to the clinical correlations of the antibody titer, and to the use of serologic reactions to detect antigens.
C41265	Significance_Level	Properties_or_Attributes	Significance Level	The probability of a type I error of a statistical hypothesis test, a fixed probability of wrongly rejecting the null hypothesis H0, if it is in fact true. It is set by the investigator in relation to the consequences of such an error. The often chosen significance level is 5%.
C41266	Subsegmental_Bronchus	Bronchus	Subsegmental Bronchus	A part the bronchial tree, an air passage arising from the segmental bronchus and passing to the naturally delimited part of lung segment (subsegment), where it further subdivides into smaller passages.
C41267	Subsegmental_Bronchus_of_Left_Lung	Subsegmental_Bronchus	Subsegmental Bronchus of Left Lung	A part the bronchial tree of the left lung, an air passage arising from any segmental bronchus of the left lung and passing to the naturally delimited part of lung segment (subsegment), where it further subdivides into smaller passages.
C41268	Subsegmental_Bronchus_of_Right_Lung	Subsegmental_Bronchus	Subsegmental Bronchus of Right Lung	A part the bronchial tree of the right lung, an air passage arising from any segmental bronchus of the right lung and passing to the naturally delimited part of lung segment (subsegment), where it further subdivides into smaller passages.
C41270	Wall_of_Body_of_Uterus	Female_Reproductive_System_Part	Wall of Body of Uterus	Wall of body of uterus is composed of three layers: endometrium, myometrium, and perimetrium. Endometrium is the inner mucosal layer lining and is covered with columnar epithelium and tubular glands. Myometrium is a thick, muscular layer, consisting largely of bundles of smooth muscle fibers arranged in longitudinal, circular, and spiral patterns, and interlaced with connective tissue. Perimetrium is the outer layer composed of the peritoneal layer of the broad ligament that covers the body of the uterus and part of the cervix.
C41275	Vial	Drug_Packaging_Device	Vial|Phial	A small, often stoppered glass or plastic bottle for holding medicines and chemicals.
C41276	Detector	Diagnostic_Therapeutic_and_Research_Equipment	Detector	A mechanical, electrical, or chemical device with sensor properties, that automatically identifies and records or registers a stimulus, such as change in pressure or temperature or content, movement, an electrical signal, radiation from a radioactive material or presence of subatomic particles, etc.
C41277	Tube	Conceptual_Entities	Tube	A hollow cylinder, especially one for holding or conveying liquids; anything shaped like such a hollow cylinder, e.g. an organic structure having the shape or function of a tube such as channel within a plant or animal body (e.g. fallopian tube).
C41278	Monitoring_Device	Medical_Device	Monitoring Device	A recording device or display that continuously keeps track of the function, condition, or operation of the system or organism and warns of an abnormal or potentially dangerous situation.
C41327	EKG_P_Wave	Electrocardiographic_Finding	EKG P Wave|P Wave	P wave is the electrical signature of the current that causes atrial contraction - the portion of the EKG tracing that represents depolarization of the atrial myocardium. Initial portion of the P wave is largely a reflection of right atrial depolarization and the terminal portion reflects depolarization of the left atrium.
C41328	Electrocardiographic_Finding	Cardiovascular_System_Finding	Electrocardiographic Finding|Electrocardiographic Findings	Results of graphic tracing and measurements of the variations in electrical potential caused by the excitation of the heart muscle and detected at the body surface in relation to the diagnosis of coronary events compared with the absolute level of the measurement. The concept encompasses entirely normal, nonspecifically abnormal, and clearly abnormal findings.
C41329	EKG_QRS_Complex	Electrocardiographic_Finding	EKG QRS Complex|QRS Complex	QRS complex is a portion of the EKG tracing that represents depolarization of the ventricular myocardium. Normally the ventricles are activated simultaneously.
C41330	EKG_ST_Segment_Depression	Electrocardiographic_Finding	EKG ST Segment Depression|ST Segment Depression	The normal ST segment of the EKG tracing begins at the isoelectric line, is typically isoelectric (flat), extending from the end of the S wave and curving gradually upward to the beginning of the T wave. Causes of ST segment depression include myocardial ischemia, digoxin effect, ventricular hypertrophy, acute posterior myocardial infarction, pulmonary embolus, left bundle branch block.
C41331	Adverse_Event	Finding_by_Cause	Adverse Event|AE|Adverse Experience	Any unfavorable or unintended symptom, sign, or disease (including abnormal lab) temporally associated with the use of a medical treatment or procedure that may or may not be considered related to the medical treatment or procedure.  Such events can be intervention related, dose related, route related, patient related, caused by an interaction with another drug.  See NCI Common Terminology Criteria for Adverse Events.
C41332	Adverse_Reaction	Finding_by_Cause	Adverse Reaction|AR|Adverse Effect	Any noxious and unintended responses to a medical product or procedure, for which a causal relationship with this product or procedure is at least a reasonable possibility i.e., the relationship cannot be ruled out. The old term Side Effect is retired and should not be used
C41333	Expected_Adverse_Event	Adverse_Event	Expected Adverse Event|EAE	Any adverse reaction to a medical product or procedure, whose nature and severity have been previously observed, identified in nature, severity, or frequency, and documented in the investigator brochure, investigational plan, protocol, current consent form, scientific publication, or in other relevant and reliable document. The old term Side Effect is retired and should not be used.
C41334	Unexpected_Adverse_Event	Adverse_Event	Unexpected Adverse Event|UAE	Any adverse experience with a medical product or procedure that has not been previously observed, whether or not the event was anticipated because of the pharmacologic properties of the study agent or the nature of the medical procedure. This includes events that are more serious than expected or occur more frequently than expected, particularly, any adverse experience, the nature, severity or frequency of which is not consistent with the current investigator brochure for investigational agent; or with the risk information described in the investigational plan or protocol or consent form.
C41335	Serious_Adverse_Event	Adverse_Event	Serious Adverse Event|SAE	Any expected or unexpected adverse event, related or unrelated to the intervention, occurring at any agent dose, any phase of product o procedure testing, that results in any of the following outcomes: death, a life-threatening adverse event, requires inpatient hospitalization (not required as part of the treatment) or prolongation of existing hospitalization, a persistent or significant disability or incapacity, or cancer, or a congenital anomaly or birth defect. Important medical events that may not result in the listed outcomes may be considered as serious when, based upon appropriate medical judgment, they represent significant hazards or potentially serious harm to the research subject or others and may require medical intervention to prevent one of the outcomes listed in this definition.
C41336	Non-serious_Adverse_Event	Adverse_Event	Non-serious Adverse Event|Non Serious Adverse Event	Any adverse experience that does not meet the definition of serious. Non-serious adverse events are classified as mild, moderate and severe.
C41337	Life_Threatening_Adverse_Event	Adverse_Event	Life Threatening or Disabling Adverse Event|Life Threatening Adverse Event	An adverse event, and/or its immediate sequelae, which is associated with an imminent risk of death or which is associated with physical or mental disabilities that affect or limit the ability of a person to perform activities of daily living (eating, ambulation, toileting, etc.) See NCI Common Terminology Criteria for Adverse Events.
C41338	Mild_Adverse_Event	Adverse_Event	Mild Adverse Event	An experience that is usually transient, and requires no special treatment or intervention. The event does not generally interfere with usual daily activities. Includes transient laboratory test alterations. See NCI Common Terminology Criteria for Adverse Events.
C41339	Moderate_Adverse_Event	Adverse_Event	Moderate Adverse Event	An experience that is alleviated with simple therapeutic treatments. The event impacts usual daily activities. Includes laboratory test alterations indicating injury, but without long-term risk.  See NCI Common Terminology Criteria for Adverse Events.
C41340	Severe_Adverse_Event	Adverse_Event	Severe Adverse Event	Severe adverse event is an experience that requires therapeutic intervention and interrupts usual daily activities.  See NCI Common Terminology Criteria for Adverse Events.
C41341	Withdrawal	Socialized_Conduct_Disorder	Withdrawal	A social or emotional detachment, pathological retreat from objective reality, interpersonal contact and social involvement, as in some forms of schizophrenia, depression, or schizoid, avoidant, or schizotypal personality disorders.
C41352	Early_Yaws	Yaws	Early Yaws	Early yaws includes primary and secondary stages of yaws, endemic tropical treponemal nonvenereal infection: development of initial lesion at inoculation site followed by widespread dissemination of treponemes and generalized secondary granulomatous lesions that may relapse repeatedly.
C41353	Yaws	Tropical_Disease	Yaws	An endemic, infectious, nonvenereal disease in humans that presents mainly in children younger than 15 years. The disease occurs primarily in warm, humid, tropical areas of Africa, Asia, South America, and Oceania, among poor rural populations where conditions of overcrowding and poor sanitation prevail. Infection with Treponema pertenue, a subspecies of Treponema pallidum, causes the disease.
C41354	Late_Yaws	Yaws	Late Yaws	Late yaws is the tertiary, non-contagious stage of yaws, endemic tropical treponemal nonvenereal infection. Late yaws is characterized by destructive and deforming lesions of the skin, bones, and joints.
C41355	EKG_Normal_Axis_Deviation	Electrocardiographic_Finding	EKG Normal Axis Deviation|Normal Axis Deviation	EKG represents the graphical information about the position of the heart in the chest (axis). The electrical axis of the heart is a term used to describe the mean direction and magnitude of electrical impulses generated by the heart during the cardiac cycle. Normally, the heart is positioned in the chest so that the majority of the electrical impulse travels downward (interior) and towards the left. The normal axis of the heart is called normal axis deviation. Age, body build, and sex may influence axis location and produce a number of normal variations. The axis may deviate from normal position due to structural problems (valve conditions), pulmonary or systemic hypertension and/or heart attacks.
C41356	Definite_Adverse_Event_Relationship_to_Product_or_Procedure	Adverse_Event_Relationship_to_Product_or_Procedure	Definite Adverse Event Relationship to Product or Procedure	Definite adverse event relationship to study product or procedure is established when there is a clear-cut temporal association between product or procedure administration and adverse event, and no other possible cause is present.
C41357	Probable_Adverse_Event_Relationship_to_Product_or_Procedure	Adverse_Event_Relationship_to_Product_or_Procedure	Probable Adverse Event Relationship to Product or Procedure	Probable adverse event relationship to study product or procedure is defined when there is a clear-cut temporal association between product or procedure administration and adverse event, and a potential alternative etiology of the event is not apparent.
C41358	Adverse_Event_Relationship_to_Product_or_Procedure	Other_Finding	Adverse Event Relationship to Product or Procedure	A specific identifiable level (defined qualitatively or quantitatively) of probability of adverse event being caused or associated with the product or procedure administration to a patient.
C41359	Possible_Adverse_Event_Relationship_to_Product_or_Procedure	Adverse_Event_Relationship_to_Product_or_Procedure	Possible Adverse Event Relationship to Product or Procedure	Possible adverse event relationship to study product or procedure is defined when there is less clear temporal association between product or procedure administration and adverse event, and other etiologies of the event are also possible.
C41360	Drug_Sensitization	Drug_Exposure	Drug Sensitization	The term describes the situation in which a constant drug dose elicits increasing effects.The condition is opposite to drug tolerance since less dose of the substance is required to reinstate the initial effect (reverse-tolerance). The concept does not refer to cumulative drug effect.
C41361	KRAS_Gene_Mutation	Oncogene_Deregulation	KRAS Gene Mutation|KRAS-2 Gene Mutation|KRAS2 Gene Mutation|c-K-ras Gene Mutation
C41362	Drug_Exposure	Finding_by_Cause	Drug Exposure	The term describes the situation in which a constant drug dose elicits increasing effects.The condition is opposite to drug tolerance since less dose of the substance is required to reinstate the initial effect (reverse-tolerance). The concept does not refer to cumulative drug effect.
C41363	MKK4_Tumor_Suppressor_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	MAP2K4 Gene Inactivation|MAP2K4 Tumor Suppressor Gene Inactivation|MKK4 Gene Inactivation|MKK4 Tumor Suppressor Gene Inactivation
C41365	Craving	Nervous_System_Finding	Craving	The desire to experience the effect(s) of a previously used psycho-active substance. It has to be noted that not all drug craving is based on withdrawal, since craving can often occur in the absence of withdrawal.
C41366	Atopy	Immune_System_Finding	Atopy|Atopic Allergy	A genetic predisposition to form IgE antibodies in response to exposure to allergens and therefore, for the development of immediate (type I) hypersensitivity and atopic conditions, such as allergic rhinitis; bronchial asthma, atopic dermatitis, and food allergy. Mutations of specific alleles on the long arm of chromosome 5 have been associated with higher levels of IL-4 and IgE and are known as IL-4 promoter polymorphisms.
C41367	AKT2_Gene_Amplification	Oncogene_Deregulation	AKT2 Gene Amplification
C41371	Loss_of_Chromosome_12	Chromosomal_Loss	Loss of Chromosome 12
C41372	Peak_Expiratory_Flow	Pulmonary_Function_Test	Peak Expiratory Flow	Peak Expiratory Flow (PEF) - one of the lung function testing parameters measuring the rate at which a patient can exhale for vital lung capacity evaluation. PEF records the maximum flow that can be sustained for 10 milliseconds on forced expiration starting from full inflation of the lungs. It is a useful tool in defining characteristics and monitoring such conditions as obstructive lung disease, asthma, and bronchitis.
C41375	Cutaneous_Oximetry	Test|Test_Generic	Cutaneous Oximetry	Noninvasive measurement or determination of the partial pressure of oxygen and carbon dioxide locally in the capillaries of a tissue by the application to the skin of a special set of electrodes. These electrodes contain photoelectric sensors capable to detect the specific wavelengths of radiation emitted by oxygenated versus reduced hemoglobin. Tissue oxygenation measurement is a useful tool for appropriate patient selection for HBO therapy and for choosing strategies for management of peripheral vascular diseases, chronic nonhealing wounds and other conditions.
C41376	Glucose_Plasma_Concentration	Diagnostic_Test	Plasma Glucose Measurement	Glucose Plasma Concentration (GPC) measurement is an essential diagnostic modality for different types of carbohydrate metabolism derangements including diabetes mellitus. The disordered carbohydrate metabolism that underlies diabetes manifests as hyperglycemia. Plasma glucose concentrations in healthy individuals vary with age. Normal fasting plasma glucose intervals (in the morning after an overnight fast) in children are 3.3 - 5.6 mmol/L (60-100 mg/dL); adult range - 4.1- 5.9 mmol/L (74-106 mg/dL). GPCs are approximately 11% higher than whole blood if the hematocrit is normal. Glucose concentrations in heparinized plasma are reported to be 5% lower than in serum.
C41377	del_3p25	Chromosomal_Deletion	del(3p25)
C41378	Derivation	Palliative_Care	Derivation	A drawing fluids from one part of the body to another, to relieve symptoms, reduce the inflammation or to otherwise lessen a morbid process.
C41379	HST-1_Gene_Amplification	Oncogene_Deregulation	FGF4 Gene Amplification|HST-1 Gene Amplification
C41380	HST-2_Gene_Amplification	Oncogene_Deregulation	FGF6 Gene Amplification|HST-2 Gene Amplification
C41381	N-RAS_Gene_Mutation	Gene_Abnormality	NRAS Gene Mutation|N-RAS Gene Mutation
C41382	TEL-PDGFbeta_Receptor_Fusion_Protein_Expression	Fusion_Protein_Expression	TEL-PDGFbeta Receptor Fusion Protein Expression
C41383	Checkup	Physical_Examination	Checkup|Check-up	Checkup is a general examination or inspection, especially one carried out by a doctor or dentist.
C41385	Human_Subject_Research	Research_Activity	Human Subject Research	A study that has gone beyond the laboratory research and the testing that can be done with experimental animals, and needs to involve humans if it is to be continued at all. Under current law, usually the testing of a new pharmaceutical product or medical device on humans is mandatory. The concept also refers to population-based research in which an investigator directly interacts with individuals.
C41386	Minimal_Risk_Study	Human_Subject_Research	Minimal Risk Study	The clinical research that involves testing an approved drug with a well-known adverse event profile, and includes physiologic measurements and procedures that carry little risk to the participant.
C41387	Diagnostic_Test_Quality_Assessment_Criterion	Technology_Assessment	Diagnostic Test Quality Assessment Criterion|Diagnostic Test Quality Assessment Criteria	A qualitative characteristic or quantitative parameter used to evaluate the performance of particular diagnostic test.
C41388	Specificity_of_Diagnostic_Test	Diagnostic_Test_Quality_Assessment_Criterion	Specificity of Diagnostic Test	The probability that test will produce a true negative result when used on non-effected subjects as compared to a reference or "gold standard". The specificity of a test can be determined by calculating: number of true negative results divided by the sum of true negative results plus number of false positive results.
C41389	Positive_Predictive_Value_of_Diagnostic_Test	Diagnostic_Test_Quality_Assessment_Criterion	Positive Predictive Value of Diagnostic Test	The probability that an individual is affected with the condition when a positive test result is observed. Predictive values should only be calculated from cohort studies or studies that legitimately reflect the number of people in the population who have the condition of interest at that time since predictive values are inherently dependent upon the prevalence. PPVDT can be determined by calculating: number of true positive results divided by the sum of true positive results plus number of false positive results.
C41390	Negative_Predictive_Value_of_Diagnostic_Test	Diagnostic_Test_Quality_Assessment_Criterion	Negative Predictive Value of Diagnostic Test	Negative Predictive Value of Diagnostic Test (NPVDT) is a probability that an individual is not affected with the condition when a negative test result is observed. This measure of accuracy should only be used if the data on the prevalence of condition of interest in given population is available. NPVDT can be determined by calculating: number of true negative results divided by the sum of true negative results plus number of false negative results.
C41392	Quality_of_Health_Care_Assessment	Clinical_or_Research_Activity	Quality of Health Care Assessment	The systemic measurement of the quality of health care that includes a broad set of perfomance measures such as the quality of services and the outcomes analysis for particular diseases and conditions, mortality and morbidity, patient safety, data on maternal and child health, as well as evaluation of quality of diagnosis, care excessability, implementation of proven evidence-based practices, quality of reporting systems for errors and adverse events, reliability and excessability of health and health care-related information, and health care organizations infrastructure.
C41393	Diagnostic_Accuracy_Assessment_Criterion	Quality_of_Health_Care_Assessment	Diagnostic Accuracy Assessment Criterion|Diagnostic Accuracy Assessment Criteria	A qualitative characteristic or quantitative parameter used to provide a reliable and valid estimate of the degree to which patients who were diagnosed with particular condition or disease, match the traditional (prototypical) conception of this disease or condition.
C41394	Diagnostic_Sensitivity	Diagnostic_Accuracy_Assessment_Criterion	Diagnostic Sensitivity	The probability that an individual who has the condition of interest is indeed classified as diseased as a result of diagnostic evaluation.
C41395	Diagnostic_Specificity	Diagnostic_Accuracy_Assessment_Criterion	Diagnostic Specificity	The probability that an individual who does not have a particular condition is classified as not diseased as a result of diagnostic evaluation.
C41396	Lot	Conceptual_Entities	Lot	Any collection in its entirety; miscellaneous articles considered as one unit for purchase.
C41397	Blasts_Under_20_Percent_of_Bone_Marrow_Nucleated_Cells	Blast_Cells_Increased_in_Bone_Marrow	Blasts Under 20 Percent of Bone Marrow Nucleated Cells
C41398	Blasts_Under_10_Percent_of_Bone_Marrow_Nucleated_Cells	Blasts_Under_20_Percent_of_Bone_Marrow_Nucleated_Cells	Blasts Under 10 Percent of Bone Marrow Nucleated Cells
C41399	Blasts_Under_5_Percent_of_Peripheral_Blood_White_Cells	Blasts_Under_10_Percent_of_Peripheral_Blood_White_Cells	Blasts Under 5 Percent of Peripheral Blood White Cells
C41400	Blasts_5-19_Percent_of_Peripheral_Blood_White_Cells	Blasts_Under_20_Percent_of_Peripheral_Blood_White_Cells	Blasts 5-19 Percent of Peripheral Blood White Cells
C41401	Blasts_10-19_Percent_of_Bone_Marrow_Nucleated_Cells	Blasts_Under_20_Percent_of_Bone_Marrow_Nucleated_Cells	Blasts 10-19 Percent of Bone Marrow Nucleated Cells
C41402	Myeloblasts_Under_10_Percent_of_Peripheral_Blood_White_Cells	Blasts_Under_10_Percent_of_Peripheral_Blood_White_Cells|Myeloblasts_Under_20_Percent_of_Peripheral_Blood_White_Cells	Myeloblasts Under 10 Percent of Peripheral Blood White Cells
C41403	Elevated_Serum_Lysozyme	Abnormal_Blood_and_Hematology_Test_Result	Elevated Serum Lysozyme
C41404	Absence_of_Bone_Marrow_Dysplasia	Normal_Bone_Marrow_Test_Results	Absence of Bone Marrow Dysplasia
C41405	Neuron_and_Supporting_Cell_of_the_Nervous_System	Cell	Neuron, Neuroepithelial Cell, and Supporting Cell of the Nervous System|Nerve Cell, Neuroepithelial Cell, and Supporting Cell of the Nervous System|Neural Cell, Neuroepithelial Cell, and Supporting Cell of the Nervous System	A grouping for all the different types of cells of the nervous system.
C41406	Nerve_and_Perineural_Tissue	Tissue	Nerve Tissue, Neuroepithelial Tissue, and Nerve Sheaths	The basic components of the nervous system.  They contain neurons, supporting cells, and neuroepithelial cells.
C41407	Perineural_Tissue	Nerve_Sheaths	Perineural Tissue	Tissue that surrounds nerves.
C41408	Neoplastic_Neuroepithelial_Cell_and_Neoplastic_Perineural_Cell	Neoplastic_Cell	Neoplastic Neuroepithelial Cell and Neoplastic Perineural Cell
C41409	Neuroepithelial_Tissue	Nerve_and_Perineural_Tissue	Neuroepithelial Tissue	Tissue composed of neuroepithelial cells. The latter include astrocytes, oligodendrocytes, ependymal cells, neuroblasts, and olfactory receptor cells.
C41410	Neuroepithelial_Cell	Neuron_and_Supporting_Cell_of_the_Nervous_System	Neuroepithelial Cell	A cell found in the nervous system. It includes glial cells, neuroblasts, and olfactory cells.
C41413	Neoplastic_Perineural_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell|Neoplastic_Neuroepithelial_Cell_and_Neoplastic_Perineural_Cell	Neoplastic Perineural Cell
C41414	Pseudo-Onion_Bulbs_Formation	Morphologic_Finding	Pseudo-Onion Bulbs Formation
C41415	Melanosomes_Present	Morphologic_Finding	Melanosomes Present
C41416	Perineural_Cell	Supporting_Cell_of_the_Nervous_System	Perineural Cell	A cell surrounding a neuron.
C41417	Vater-Pacini_Corpuscles-like_Structures_Present	Morphologic_Finding	Vater-Pacini Corpuscles-like Structures Present
C41421	Cystic_Lesion	Lesion	Cystic Lesion
C41422	Multicystic_Lesion	Cystic_Lesion	Multicystic Lesion
C41423	Unicystic_Lesion	Cystic_Lesion	Unicystic Lesion
C41424	Loss_of_Merlin_Expression	Protein_Deregulation	Loss of Merlin Expression
C41425	Nodular_Lesion	Lesion	Nodular Lesion
C41426	Atypical_Neurofibroma	Neurofibroma	Atypical Neurofibroma
C41427	Cellular_Neurofibroma	Neurofibroma	Cellular Neurofibroma
C41428	Increased_Cellularity_Present	Morphologic_Finding	Increased Cellularity Present
C41429	Absense_of_Malignant_Features	Morphologic_Finding	Absense of Malignant Features
C41430	Peripheral_Nerve_Schwannoma	Peripheral_Nervous_System_Neoplasm|Schwannoma	Peripheral Nerve Schwannoma
C41431	Thick-Walled_Hyalinized_Vessels_Present	Hyalinized_Vessels_Present	Thick-Walled Hyalinized Vessels Present
C41432	Pseudoencapsulated_Mass	Mass	Pseudoencapsulated Mass
C41433	Geographic_Necrosis	Necrotic_Change	Geographic Necrosis
C41434	Malignant_Perineural_Cell	Malignant_Connective_and_Soft_Tissue_Cell|Neoplastic_Perineural_Cell	Malignant Perineural Cell
C41435	Malignant_Epithelioid_Cell	Neoplastic_Epithelioid_Cell	Malignant Epithelioid Cell
C41436	Sex_Not_Known	Retired_Concepts	Sex Not Known|Not Known	Sex type was not observed or recorded.
C41437	Sex_Not_Specified	Retired_Concepts	Sex Undifferentiated	Sex type could not be determined.
C41438	Undifferentiated_Sex	General_Modifier	Undifferentiated Sex|Not Specified|Sex Not Specified|Undifferentiated	Sex could not be determined; not uniquely defined; undifferentiated.
C41439	Nerve_Sheaths	Nerve_Tissue_and_Nerve_Sheaths|Soft_Tissue	Nerve Sheaths	Protective covers encircling nerves, nerve fibers or axons.
C41440	Diagnostic_Accuracy	Quality_of_Health_Care_Assessment	Diagnostic Accuracy|Accuracy of Diagnosis	Tthe proportion of all the observations that have been classified correctly by the diagnostic procedures in given population, or using some diagnostic test, or by some medical institution or professional.
C41441	_12-Allyldeoxoartemisinin	Antimalarial_Agent	12-Allyldeoxoartemisinin	A semi-synthetic analogue of Artemisinin - a sesquiterpene lactone extracted from the dry leaves of Artemisia Annua (sweet wormwood) used as anti-malaria agent. Limited data is available on Artemisinin antineoplastic activity.
C41442	Perineurial_Cell	Perineural_Cell	Perineurial Cell	A cell that belongs to the supporting tissue surrounding a nerve fiber bundle. It has thin long bipolar cytoplasmic processes, pinocytotic vesicles, fragments of external lamina and/or external lamina-like material, attachment plaques, and desmosome-like junctions.
C41443	Nerve_Tissue_and_Nerve_Sheaths	Nerve_and_Perineural_Tissue	Nerve Tissue and Nerve Sheaths	Tissues that contain neurons and supporting cells that form the covers encircling nerves, nerve fibers, and axons.
C41444	Secondary_Lesion	Lesion	Secondary Lesion
C41445	Visual_Pathway	Neural_Pathway	Visual Pathway
C41448	Subependymal_Tissue	Ependyma_and_Remnants_of_the_Central_Canal_of_the_Spinal_Cord	Subependymal Tissue	Tissue located below the ependyma lining the ventricles of the brain and central canal of the spinal cord. It is a dense feltwork of glial processes and is believed to contain neural stem cells.
C41449	Epidural_Spinal_Canal_Space	Musculoskeletal_System_Part	Epidural Spinal Canal Space
C41450	Intradural_Extramedullary_Spinal_Canal_Space	Musculoskeletal_System_Part	Intradural Extramedullary Spinal Canal Space
C41451	Neoplastic_Subependymal_Cell	Neoplastic_Ependymal_Cell	Neoplastic Subependymal Glial Cell
C41452	Subependymal_Cell	Ependymocyte	Subependymal Cell	A neuroepithelial cell that is situated just beneath the ependyma, which is the lining membrane of the ventricles of the brain and of the central canal of the spinal cord.
C41453	Infiltrative_Pattern	Morphologic_Architectural_Pattern	Infiltrative Growth
C41454	Cystic_Changes	Morphologic_Finding	Cystic Changes|Cystic Structures Present
C41455	Microvascular_Proliferation	Vascular_Proliferation	Microvascular Proliferation
C41456	Microcystic_Changes	Cystic_Changes	Microcystic Changes|Microcystic Structures Present
C41457	Circumscribed_Lesion	Lesion	Circumscribed Lesion
C41458	Slow_Growing_Mass	Mass	Slow Growing Mass
C41459	Neoplastic_Multipolar_Astrocyte_with_Microcysts_and_Granular_Bodies	Neoplastic_Astrocyte	Neoplastic Protoplasmic Astrocyte|Neoplastic Multipolar Astrocyte
C41460	Low_Cellularity_Present	Morphologic_Finding	Low Cellularity Present
C41461	Hyalinized_Vessels_Present	Vascular_Morphologic_Change	Hyalinized Vessels Present
C41463	Eosinophilic_Granular_Bodies_Present	Morphologic_Finding	Eosinophilic Granular Bodies Present
C41464	Macrocystic_Changes	Cystic_Changes	Macrocystic Changes|Macrocystic Structures Present
C41465	Rosenthal_Fibers_Present	Morphologic_Finding	Rosenthal Fibers Present
C41466	Multinodular_Lesion	Nodular_Lesion	Multinodular Lesion
C41467	Dense_Intercellular_Reticulin_Network_Present	Morphologic_Finding	Dense Intercellular Reticulin Network Present
C41468	Intracellular_Accumulation_of_Lipids	Morphologic_Finding	Intracellular Accumulation of Lipids
C41469	Neoplastic_Large_Ganglioid_Astrocyte	Neoplastic_Astrocyte	Neoplastic Large Ganglioid Astrocyte
C41470	Perivascular_Pseudopalisading	Morphologic_Architectural_Pattern	Perivascular Pseudopalisading
C41471	Gliomatous_Differentiation	Tissue_Differentiation	Glial Differentiation
C41472	Collagenous_Stroma_Formation	Stromal_Change	Collagenous Stroma Formation
C41473	Cardiovascular_Alteration	Circulatory_Process	Cardiovascular Alteration	Cardiovascular Alteration involves a change in the existing function of biologic molecules and complexes, or cellular, cell, or tissue components of the heart and vascular system by which blood is pumped and circulated through the body to provide tissues with oxygen and nutrients and to remove waste products.
C41474	Dihydrotestosterone_Secretion_Induction	Testosterone_Secretion_Induction	Dihydrotestosterone Secretion Induction	Dihydrotestosterone Secretion Induction involves stimulation of dihydrotestosterone release into the bloodstream from the testes. Alteration of positive or negative feedback mechanisms or induction of testosterone synthesis will stimulate dihydrotestosterone synthesis and release.
C41475	Testosterone_Secretion_Induction	Endocrine_Secretory_Induction	Testosterone Secretion Induction	Testosterone Secretion Induction consists of initiation of activities involved in release into the bloodstream by testicular interstitial (Leydig's) cells of the major androgenic steroid hormone (testosterone) produced in response to adenohypophyseal luteinizing hormone that regulates gonadotropic secretion; Wolffian duct differentiation into epididymis, vas deferens, and seminal vesicle; spermatogenesis after peripheral conversion to dihydrotestosterone by 5a-reductase; and skeletal muscle and bone tissue. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41476	Estrogen_Activity_Inhibition	Hormone_Activity_Inhibition	Estrogen Activity Inhibition	Estrogen Activity Inhibition involves interference with, such as receptor binding, or restraint of the biological function of biochemical substances (estrogens) secreted by the ovaries that have a specific regulatory effect on the activity of cells involved in development and maintenance of secondary female sex characteristics and control of the cyclical changes in the reproductive cycle, as well as pregnancy maintenance and an anabolic effect on protein metabolism and water retention.
C41477	Respiratory_Process	Organismal_Process	Respiratory Process	A Respiratory Process involves the function of components of the respiratory tract involved in breathing, which include the nose, throat, larynx, trachea, bronchi, and lungs.
C41478	Reproductive_System_Process	Organismal_Process	Reproductive System Process	A Reproductive System Process involves a function of cellular, cell, or tissue components of the organ system involved in generation of offspring that includes the ovaries, fallopian tubes, uterus, cervix, and vagina in women or the prostate, testes, and penis in men.
C41479	Renal_and_Urologic_Process	Organismal_Process	Renal and Urologic Process	A Renal and Urologic Process consists of functions of cellular, cell, or tissue components of organs that produce and discharge urine, which include the kidneys, ureters, bladder, and urethra.
C41480	Musculoskeletal_Process	Organismal_Process	Musculoskeletal Process	A Musculoskeletal Process consists of a function of cellular, cell, or tissue components of the organ system comprised of muscle, bone, and cartilage.
C41481	Gastrointestinal_Process	Organismal_Process	Gastrointestinal Process	A Gastrointestinal Process involves the function of components of the digestive system, which includes the esophagus, stomach, small and large intestine, anus, liver, biliary tract, and pancreas.
C41482	Gastrointestinal_Secretory_Inhibition	Gastrointestinal_Process	Gastrointestinal Secretory Inhibition	Gastrointestinal Secretory Inhibition involves interference with, or restraint of, gastric and intestinal fluid release from cells into the lumen of the gastrointestinal (GI) tract. Suppression decreases digestion and absorption of nutrients as well as protection and lubrication of the GI tract.
C41483	Saliva_Production_Inhibition	Gastrointestinal_Secretory_Inhibition	Saliva Production Inhibition	Saliva Production Inhibition involves interference with, or restraint of, synthesis of the clear, slightly acid (pH 6.8) viscous fluid secreted from the parotid, sublingual, and submandibular salivary glands and the mucous glands of the oral cavity that contain mucins, water, organic salts, and ptylin and keep the oral mucous membrane moist, lubricate food, and partially convert starch into maltose.
C41484	Gastrointestinal_Secretory_Induction	Gastrointestinal_Process	Gastrointestinal Secretory Induction	Gastrointestinal Secretory Induction involves stimulation of gastric and intestinal fluid release from cells into the lumen of the gastrointestinal (GI) tract. Stimulation aids digestion and absorption of nutrients as well as protection and lubrication of the GI tract.
C41485	Saliva_Production_Induction	Gastrointestinal_Secretory_Induction	Saliva Production Induction	Saliva Production Induction involves initiation of synthesis of the clear, slightly acid (pH 6.8) viscous fluid secreted from the parotid, sublingual, and submandibular salivary glands and the mucous glands of the oral cavity that contain mucins, water, organic salts, and ptylin and keep the oral mucous membrane moist, lubricate food, and partially convert starch into maltose.
C41486	Thyroid_Hormone_Secretion_Inhibition	Endocrine_Secretory_Inhibition	Thyroid Hormone Secretion Inhibition	Thyroid Hormone Secretion Inhibition consists of interference with, or restraint of, activities involved in release into the bloodstream by thyroid gland follicular cells of closely related iodine-containing triiodothyronine and thyroxine (thyroid hormones) formed from thyroglobulin that increase the rate of cell metabolism and are essential for central nervous system maturation. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41487	Gastric_Acid_Secretion_Induction	Gastrointestinal_Secretory_Induction	Gastric Acid Secretion Induction	Gastric Acid Secretion Induction involves stimulation of hydrochloric acid release from gastric cells into the lumen of the stomach. Stimulation results in release of pepsinogen and inactivation of ingested microorganisms.
C41488	Bile_Secretion_Inhibition	Gastrointestinal_Secretory_Inhibition	Bile Secretion Inhibition	Bile Secretion Inhibition consists of interference with, or restraint of, activities involved in release from the gallbladder into the duodenum of an emulsifying agent (bile) produced in the liver that contains bile acids and salts, cholesterol, and electrolytes and that aids digestion of fats.
C41489	Bile_Secretion_Induction	Gastrointestinal_Secretory_Induction	Bile Secretion Induction	Bile Secretion Induction involves initiation of activities involved in release from the gallbladder into the duodenum of an emulsifying agent (bile) produced in the liver that contains bile acids and salts, cholesterol, and electrolytes and that aids digestion of fats.
C41490	Gastrointestinal_Absorption_Induction	Gastrointestinal_Process	Gastrointestinal Absorption Induction	Gastrointestinal Absorption Induction involves initiation of activities of uptake from the intestinal lumen of fluids, solutes, proteins, fats, and other nutrients into the intestinal epithelial cells, blood, lymph, or interstitial fluids.
C41491	Gastrointestinal_Absorption_Inhibition	Gastrointestinal_Process	Gastrointestinal Absorption Inhibition	Gastrointestinal Absorption Inhibition involves interference with, or restraint of, activities of uptake from the intestinal lumen of fluids, solutes, proteins, fats, and other nutrients into the intestinal epithelial cells, blood, lymph, or interstitial fluids.
C41492	Endocrine_System_Process	Organismal_Process	Endocrine System Process	An Endocrine System Process consists of function of cellular, cell, or tissue components of glands that release hormones into the circulatory system.
C41493	Endocrine_Secretory_Induction	Endocrine_System_Process	Endocrine Secretory Induction	Endocrine Secretory Induction involves stimulation of hormone release into the bloodstream from endocrine glands. Alteration of positive or negative feedback mechanisms can induce hormone release.
C41494	Endocrine_Secretory_Inhibition	Endocrine_System_Process	Endocrine Secretory Inhibition	Endocrine Secretory Inhibition involves interference with, or restraint of, hormone release into the bloodstream from endocrine glands. Alteration of positive or negative feedback mechanisms can inhibit hormone release.
C41495	Thyroid_Hormone_Secretion_Induction	Endocrine_Secretory_Induction	Thyroid Hormone Secretion Induction	Thyroid Hormone Secretion Induction consists of initiation of activities involved in release into the bloodstream by thyroid gland follicular cells of closely related iodine-containing triiodothyronine and thyroxine (thyroid hormones) formed from thyroglobulin that increase the rate of cell metabolism and are essential for central nervous system maturation. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41496	Testosterone_Secretion_Inhibition	Endocrine_Secretory_Inhibition	Testosterone Secretion Inhibition	Testosterone Secretion Inhibition consists of interference with, or restraint of, activities involved in release into the bloodstream by testicular interstitial (Leydig's) cells of the major androgenic steroid hormone (testosterone) produced in response to adenohypophyseal luteinizing hormone that regulates gonadotropic secretion; Wolffian duct differentiation into epididymis, vas deferens, and seminal vesicle; spermatogenesis after peripheral conversion to dihydrotestosterone by 5a-reductase; and skeletal muscle and bone tissue. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41497	Dihydrotestosterone_Secretion_Inhibition	Testosterone_Secretion_Inhibition	Dihydrotestosterone Secretion Inhibition	Dihydrotestosterone Secretion Inhibition involves interference with, or restraint of, dihydrotestosterone release into the bloodstream from the testes. Alteration of positive or negative feedback mechanisms or inhibition of testosterone synthesis will suppress dihydrotestosterone synthesis and release.
C41498	Progesterone_Secretion_Inhibition	Endocrine_Secretory_Inhibition	Progesterone Secretion Inhibition	Progesterone Secretion Inhibition consists of interference with, or restraint of, activities involved in release into the bloodstream by the corpus luteum and placenta of a steroid estrogen antagonist (progesterone) that prevents follicular development and promotes proliferation of uterine mucosa and blastocyst implantation. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41499	Progesterone_Secretion_Induction	Endocrine_Secretory_Induction	Progesterone Secretion Induction	Progesterone Secretion Induction consists of the initiation of activities involved in release into the bloodstream by the corpus luteum and placenta of a steroid estrogen antagonist (progesterone) that prevents follicular development and promotes proliferation of uterine mucosa and blastocyst implantation. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41500	Norepinephrine_Secretion_Inhibition	Endocrine_Secretory_Inhibition	Norepinephrine Secretion Inhibition	Norepinephrine Secretion Inhibition consists of interference with, or restraint of, the activities involved in release into the bloodstream of a catecholamine hormone and sympathetic neurotransmitter (norepinephrine) involved in stimulation of alpha-adrenergic (vasoconstriction), beta(1)-adrenergic (increase myocardial contractility, heart rate, and AV conduction), and beta(2)-adrenergic (peripheral vasodilation) activity. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41501	Norepinephrine_Secretion_Induction	Endocrine_Secretory_Induction	Norepinephrine Secretion Induction	Norepinephrine Secretion Induction consists of initiation of activities involved in release into the bloodstream of a catecholamine hormone and sympathetic neurotransmitter (norepinephrine) involved in stimulation of alpha-adrenergic (vasoconstriction), beta(1)-adrenergic (increase myocardial contractility, heart rate, and AV conduction), and beta(2)-adrenergic (peripheral vasodilation) activity. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41502	Mineralocorticoid_Secretion_Inhibition	Endocrine_Secretory_Inhibition	Mineralocorticoid Secretion Inhibition	Mineralocorticoid Secretion Inhibition consists of interference with, or restraint of, activities involved in release into the bloodstream of a class of C21 corticosteroids (mineralocorticoids) involved in regulation of electrolyte homeostasis (sodium retention and potassium loss) and water balance (retention) through effects on epithelial ion transport. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41503	Mineralocorticoid_Secretion_Induction	Endocrine_Secretory_Induction	Mineralocorticoid Secretion Induction	Mineralocorticoid Secretion Induction consists of initiation of activities involved in release into the bloodstream of a class of C21 corticosteroids (mineralocorticoids) involved in regulation of electrolyte homeostasis (sodium retention and potassium loss) and water balance (retention) through effects on epithelial ion transport. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41504	Melatonin_Secretion_Inhibition	Endocrine_Secretory_Inhibition	Melatonin Secretion Inhibition	Melatonin Secretion Inhibition consists of interference with, or restraint of, activities involved in release into the bloodstream from the pineal gland of a hormone (melatonin) implicated in regulation of sleep, mood, puberty, and ovarian cycles.
C41505	Glucocorticoid_Secretion_Inhibition	Endocrine_Secretory_Inhibition	Glucocorticoid Secretion Inhibition	Glucocorticoid Secretion Inhibition consists of interference with, or restraint of, activities involved in release into the bloodstream by the adrenal cortex of a class of steroid substances (glucocorticoids) that affect fat, protein, and carbohydrate metabolism (gluconeogenesis, liver glycogen deposition, elevation of blood sugar); inhibit corticotropin secretion; possess anti-inflammatory activity; and play a role in arterial blood pressure, connective tissue response to injury, reduction of circulating lymphocytes, and central nervous system function. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41506	Estrogen_Secretion_Inhibition	Endocrine_Secretory_Inhibition	Estrogen Secretion Inhibition	Estrogen Secretion Inhibition consists of interference with, or restraint of, activities involved in release into the bloodstream by the ovaries of a class of steroid substances (estrogens) that have a specific regulatory effect on the activity of cells involved in development and maintenance of secondary female sex characteristics and control of the cyclical changes in the reproductive cycle, as well as pregnancy maintenance and an anabolic effect on protein metabolism and water retention. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41507	Estrogen_Secretion_Induction	Endocrine_Secretory_Induction	Estrogen Secretion Induction	Estrogen Secretion Induction consists of the initiation of activities involved in release into the bloodstream by the ovaries of a class of steroid substances (estrogens) that have a specific regulatory effect on the activity of cells involved in development and maintenance of secondary female sex characteristics and control of the cyclical changes in the reproductive cycle, as well as pregnancy maintenance and an anabolic effect on protein metabolism and water retention. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41508	Epinephrine_Secretion_Inhibition	Endocrine_Secretory_Inhibition	Epinephrine Secretion Inhibition	Epinephrine Secretion Inhibition consists of interference with, or restraint of, activities involved in release across the cell membrane into the bloodstream from the adrenal medulla of a sympathomimetic hormone (epinephrine) that stimulates the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41509	Epinephrine_Secretion_Induction	Endocrine_Secretory_Induction	Epinephrine Secretion Induction	Epinephrine Secretion Induction consists of the initiation of activities involved in release across the cell membrane into the bloodstream from the adrenal medulla of a sympathomimetic hormone (epinephrine) that stimulates the alpha- and beta- adrenergic systems, causes systemic vasoconstriction and gastrointestinal relaxation, stimulates the heart, and dilates bronchi and cerebral vessels. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41510	Circulatory_Process	Organismal_Process	Circulatory Process	A Circulatory Process consists of functions of cellular, cell, or tissue components of the heart or blood vessels by which blood is pumped and circulated through the body to provide tissues with oxygen and nutrients and to remove waste products.
C41511	Intercellular_Communication_Process	Multicellular_Process	Intercellular Communication Process	An Intercellular Communication Process consists of activities of biologic molecules, biologic complexes, or subcellular components involved in the transmission of signals between cells.
C41512	Immunosuppression_Effect	Retired_Concepts	Immunosuppression Effect
C41513	Cell_Differentiation_Process	Developmental_Process	Cell Differentiation Process	A Cell Differentiation Process in multicellular organisms consists of genetically controlled activities of biologic molecules, complexes, subcellular components, or cells involved in progressive restriction of cellular developmental potential in which immature (unspecialized) precursor cells become functionally and morphologically mature (specialized), leading to the formation of organs, tissues, and specialized cell types.
C41514	Cell_Adhesion_Process	Multicellular_Process	Cell Adhesion Process	A Cell Adhesion Process consists of the activities of biologic molecules, biologic complexes, or subcellular components that promote the adherence of cells to surfaces or to other cells.
C41515	Cell_Death_Process	Cell_Viability_Process	Cell Death Process	A Cell Death Process consists of activities of biologic molecules, biologic complexes, or subcellular components within a cell or among cells that lead to the termination of a cell's ability to carry out vital functions such as metabolism, growth, reproduction, responsiveness, and adaptability.
C41516	Cytolysis_Inhibition	Cell_Death_Inhibition	Cytolysis Inhibition	Cytolysis Inhibition involves interference with, or restraint of, cell membrane rupture, loss of cytoplasm, and dissolution or destruction of cells.
C41517	Cell_Movement_Process	Cellular_Process	Cell Movement Process	A Cell Movement Process consists of a change of position or place of a major cell surface extension (such as cilia, axons, micorovilli, filopodia), or of a whole cell or a cell body from one site to another. (NCI)
C41518	Intercellular_Signaling_Alteration	Cell_Signaling_Process	Intercellular Signaling Alteration	Intercellular Signaling Alteration involves a change in the quality of the existing state of communication between cells, whether by direct cell contact or by chemical signals.
C41519	Hormone_Activity_Induction	Intercellular_Signaling_Alteration	Hormone Activity Induction	Hormone Activity Induction involves initiation of the biological function of a biochemical substance (typically secreted by an endocrine gland) having a selective regulatory effect on the activity of a specific cell type(s) or organ(s).
C41520	Hormone_Activity_Inhibition	Intercellular_Signaling_Alteration	Hormone Activity Inhibition	Hormone Activity Inhibition involves interference with, or restraint of, the biological function of a biochemical substance (typically secreted by an endocrine gland) having a selective regulatory effect on the activity of a specific cell type(s) or organ(s).
C41521	Neurotransmitter_Activity_Inhibition	Intercellular_Signaling_Alteration	Neurotransmitter Activity Inhibition	Neurotransmitter Activity Inhibition involves interference with, such as receptor binding, decreased production, neuronal release, or increased re-uptake, or restraint of the biological function of endogenous signaling molecules secreted by neurons that have specific regulatory effects on the activity of ion channels or second messenger systems in target effector cells.
C41522	Neurotransmitter_Activity_Induction	Intercellular_Signaling_Alteration	Neurotransmitter Activity Induction	Neurotransmitter Activity Induction involves initiation of the biological function, through increased production, neuronal release, or decreased re-uptake, of endogenous signaling molecules secreted by neurons that have specific regulatory effects on the activity of ion channels or second messenger systems in target effector cells.
C41523	Adrenal_Hormone_Activity_Inhibition	Hormone_Activity_Inhibition	Adrenal Hormone Activity Inhibition	Adrenal Hormone Activity Inhibition involves interference with, such as receptor binding, or restraint of the biological function of biochemical substances secreted by the adrenal gland that have a specific regulatory effect on electrolyte balance, blood pressure, inflammation, blood sugar balance, and immune system control.
C41524	Androgen_Activity_Inhibition	Hormone_Activity_Inhibition	Androgen Activity Inhibition	Androgen Activity Inhibition involves interference with, such as receptor binding, or restraint of the biological function of biochemical substances (androgens) secreted by the testes that have a specific regulatory effect on the activity of cells involved in development and maintenance of male sex characteristics.
C41525	Estrogen_Activity_Induction	Hormone_Activity_Induction	Estrogen Activity Induction	Estrogen Activity Induction involves initiation of the biological function of biochemical substances (estrogens) secreted by the ovaries that have a specific regulatory effect on the activity of cells involved in development and maintenance of secondary female sex characteristics and control of the cyclical changes in the reproductive cycle, as well as pregnancy maintenance and an anabolic effect on protein metabolism and water retention.
C41526	Adrenal_Hormone_Activity_Induction	Hormone_Activity_Induction	Adrenal Hormone Activity Induction	Adrenal Hormone Activity Induction involves initiation of the biological function of biochemical substances secreted by the adrenal gland that have a specific regulatory effect on electrolyte balance, blood pressure, inflammation, blood sugar balance, and immune system control.
C41527	Androgen_Activity_Induction	Hormone_Activity_Induction	Androgen Activity Induction	Androgen Activity Induction involves initiation of the biological function of biochemical substances (androgens) secreted by the testes that have a specific regulatory effect on the activity of cells involved in development and maintenance of male sex characteristics.
C41528	Histamine_Activity_Inhibition	Neurotransmitter_Activity_Inhibition	Histamine Activity Inhibition	Through decreased production or release, Histamine Activity Inhibition involves interference with, or restraint of, the biological function of a decarboxylation product of histidine (histamine), found particularly in mast cells and basophils, and involved in capillary dilation and permeability; blood pressure decrease; smooth muscle contraction; gastric secretion; heart rate acceleration; immediate hypersensitivity; and central neurotransmission.
C41529	Nitric_Oxide_Activity_Inhibition	Neurotransmitter_Activity_Inhibition	Nitric Oxide Activity Inhibition	Through decreased production or release, Nitric Oxide Activity Inhibition involves interference with, or restraint of, the biological function of a substance (nitric oxide) formed by arginine oxidation catalyzed by Nitric Oxide Synthase that mediates cell communication, activates cytosolic guanylate cyclase or protein nitrosylation, and has a specific vasodilatory effect on vascular smooth muscle cells induced by acetylcholine and bradykinin, inhibits platelet aggregation, and mediates neuron to neuron signaling.
C41530	Serotonin_Activity_Inhibition	Neurotransmitter_Activity_Inhibition	Serotonin Activity Inhibition	Through decreased production or release, or increased re-uptake, Serotonin Activity Inhibition involves interference with, or restraint of, the biological function of a secreted biochemical messenger and regulator (serotonin) synthesized from L-Tryptophan that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity through multiple receptor families on specific target cells.
C41531	Histamine_Activity_Induction	Neurotransmitter_Activity_Induction	Histamine Activity Induction	Through increased production or release, Histamine Activity Induction consists of initiation of the biological function of a decarboxylation product of histidine (histamine), found particularly in mast cells and basophils, and involved in capillary dilation and permeability; blood pressure decrease; smooth muscle contraction; gastric secretion; heart rate acceleration; immediate hypersensitivity; and central neurotransmission.
C41532	Nitric_Oxide_Activity_Induction	Neurotransmitter_Activity_Induction	Nitric Oxide Activity Induction	Through increased production or release, Nitric Oxide Activity Induction involves initiation of the biological function of a substance (nitric oxide) formed by arginine oxidation catalyzed by Nitric Oxide Synthase that mediates cell communication, activates cytosolic guanylate cyclase or protein nitrosylation, and has a specific vasodilatory effect on vascular smooth muscle cells induced by acetylcholine and bradykinin, inhibits platelet aggregation, and mediates neuron to neuron signaling.
C41533	Serotonin_Activity_Induction	Neurotransmitter_Activity_Induction	Serotonin Activity Induction	Through increased production or release, or decreased re-uptake, Serotonin Activity Induction involves initiation of the biological function of a secreted biochemical messenger and regulator (serotonin) synthesized from L-Tryptophan that mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity through multiple receptor families on specific target cells.
C41534	Signal_Transduction_Alteration	Cell_Signaling_Process	Signal Transduction Alteration	Signal Transduction Alteration involves a change in the quality of existing cellular processes by which a cell propagates information from an extracellular signal through a series of biochemical reactions inside the cell to produce biological responses to events in the environment or internal milieu.
C41535	Eicosanoid_Activity_Induction	Signal_Transduction_Alteration	Eicosanoid Activity Induction	Through increased production or release, or inhibited degradation, Eicosanoid Activity Induction involves initiation of the biological function of hormone-like endogenous unsaturated and oxygenated fatty acid derivatives of arachidonic acid (eicosanoids) that act near the site of synthesis and have a specific regulatory effect on the activity of target cells in host defense reactions, immediate hypersensitivity, and inflammation. Eicosanoids include prostaglandins, leukotrienes, thromboxanes, and hydroxyeicosatetraenoic acid compounds.
C41536	Leukotriene_Activity_Induction	Eicosanoid_Activity_Induction	Leukotriene Activity Induction	Through increased production or release, or inhibited degradation, Leukotriene Activity Induction involves initiation of the biological function of a family of oxidative derivatives of arachidonic acid (5-lipoxygenase pathway) (leukotrienes) having potent regulatory effects on the activity of cardiovascular, pulmonary, central neural, gastrointestinal, and immune system cells involved in host defense, immediate hypersensitivity, and inflammation.
C41537	Prostaglandin_Activity_Induction	Eicosanoid_Activity_Induction	Prostaglandin Activity Induction	Through increased production or release, or inhibited degradation, Prostaglandin Activity Induction involves initiation of the biological function of compounds derived primarily from arachidonic acid (cyclooxygenase pathway) (prostaglandins) having potent regulatory effects on the activity of cells involved in host defense and inflammation.
C41538	Thromboxane_Activity_Induction	Eicosanoid_Activity_Induction	Thromboxane Activity Induction	Through increased production or release, or inhibited degradation, Thromboxane Activity Induction involves initiation of the biological function of widely distributed compounds formed by cyclooxygenase from polyunsaturated fatty acid prostaglandin endoperoxides (thromboxanes) and have a regulatory effect on platelet aggregation, contraction of arteries, and other biological effects.
C41539	Eicosanoid_Activity_Inhibition	Signal_Transduction_Alteration	Eicosanoid Activity Inhibition	Through decreased production or release, or enhanced degradation, Eicosanoid Activity Inhibition involves interference with, or restraint of, the biological function of hormone-like endogenous unsaturated and oxygenated fatty acid derivatives of arachidonic acid (eicosanoids) that act near the site of synthesis and have a specific regulatory effect on the activity of target cells in host defense reactions, immediate hypersensitivity, and inflammation. Eicosanoids include prostaglandins, leukotrienes, thromboxanes, and hydroxyeicosatetraenoic acid compounds.
C41540	Leukotriene_Activity_Inhibition	Eicosanoid_Activity_Inhibition	Leukotriene Activity Inhibition	Through decreased production or release, or enhanced degradation, Leukotriene Activity Inhibition involves interference with, or restraint of, the biological function of a family of oxidative derivatives of arachidonic acid (5-lipoxygenase pathway) (leukotrienes) having potent regulatory effects on the activity of cardiovascular, pulmonary, central neural, gastrointestinal, and immune system cells involved in host defense, immediate hypersensitivity, and inflammation.
C41541	Prostaglandin_Activity_Inhibition	Eicosanoid_Activity_Inhibition	Prostaglandin Activity Inhibition	Through decreased production or release, or enhanced degradation, Prostaglandin Activity Inhibition involves interference with, or restraint of, the biological function of compounds derived primarily from arachidonic acid (cyclooxygenase pathway) (prostaglandins) having potent regulatory effects on the activity of cells involved in host defense and inflammation.
C41542	Thromboxane_Activity_Inhibition	Eicosanoid_Activity_Inhibition	Thromboxane Activity Inhibition	Through decreased production and release, or enhanced degradation, Thromboxane Activity Inhibition involves interference with, or restraint of, the biological function of widely distributed compounds formed by cyclooxygenase from polyunsaturated fatty acid prostaglandin endoperoxides (thromboxanes) and have a regulatory effect on platelet aggregation, contraction of arteries, and other biological effects.
C41543	DNA_Maintenance_Process	Biochemical_Process	DNA Maintenance Process	A DNA Maintenance Process consists of activities of biologic molecules, complexes, or subcellular components that preserve DNA integrity through faithful DNA replication, DNA repair, or recombination. (NCI)
C41544	Catabolic_Process	Intermediary_Metabolism	Catabolic Process	A Catabolic Process consists of activities of biologic molecules, biologic complexes, or subcellular components involved in the enzyme-catalyzed biochemical process by which complex molecules are degraded to simpler molecules releasing energy.
C41545	Nucleotide_Biosynthesis	Nucleotide_Metabolism	Nucleotide Biosynthesis	Nucleotide Biosynthesis consists of activities of biologic molecules or complexes involved in the enzymatic formation of nucleoside phosphates, the monomeric building blocks from which DNA or RNA polymers are constructed that consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group.
C41546	Resistance_Process	Metabolic_Process	Resistance Process	A Resistance Process consists of activities of biologic molecules or complexes involved in processes that maintain immunity to, or counteract, defeat, or withstand the effects of, an antagonistic agent.
C41547	Fluid_Absorption_Alteration	Osmotic_Activity	Fluid Absorption Alteration	Fluid Absorption Alteration involves a qualitative change in the existing state of water diffusion from the renal or intestinal lumen into renal or intestinal epithelial cells, blood, lymph, or interstitial fluids.
C41548	Fluid_Secretion_Alteration	Osmotic_Activity	Fluid Secretion Alteration	Fluid Secretion Alteration involves a qualitative change in the existing state of water diffusion from the renal or intestinal epithelial cells, blood, lymph, or interstitial fluids into the renal or intestinal lumen.
C41549	Enzyme_Secretion_Alteration	Protein_Secretion	Enzyme Secretion Alteration	Enzyme Secretion Alteration involves a change in the quality of the existing state of movement out of a cell (across the cell membrane) or organ of origin into the intracellular space or ducts of catalytic proteins, RNA, or DNA.
C41550	Ion_Transport_Alteration	Transmembrane_Transport	Ion Transport Alteration	Ion Transport Alteration involves a change in the quality of the existing state of active uptake into, across or out of tissues or active translocation across a cell membrane from one site or compartment to another of an atom, radical, or substance having a positive or negative electrical charge owing to the loss or gain of electron(s).
C41551	Electrolyte_Absorption_Alteration	Ion_Transport_Alteration	Electrolyte Absorption Alteration	Electrolyte Absorption Alteration involves a change in the quality of the existing state of active uptake into or across tissues or active translocation across a cell membrane from one site or compartment to another of a substance having a positive or negative electrical charge owing to the loss or gain of electron(s). Electrolytes regulate nerve and muscle function and water distribution between cells, plasma, and interstitial fluid.
C41552	Electrolyte_Secretion_Alteration	Ion_Transport_Alteration	Electrolyte Secretion Alteration	Electrolyte Secretion Alteration involves a change in the quality of the existing state of active translocation across a cell membrane into the intracellular space or movement out of an organ of origin of a substance having a positive or negative electrical charge owing to the loss or gain of electron(s).
C41553	Deacetylation	Biochemical_Reaction	Deacetylation	Deacetylation is the covalent chemical or post-translational biochemical addition of an acetyl group(s) to a peptide or protein. (NCI)
C41554	Lewis_Y_Antigen_Binding	Antigen_Binding_Interaction	Lewis Y Antigen Binding	Lewis Y Antigen Binding involves non-covalent interaction of a molecule through intermolecular physical forces of attraction with the Lewis Y cell surface antigen.
C41555	Phospholipid_Interaction	Lipid_Binding	Phospholipid Binding	Phospholipid Interaction involves temporary non-covalent binding of a molecule through intermolecular physical forces of attraction with a member of a heterogeneous group of water-insoluble aliphatic hydrocarbons that contain phosphorus (phosphoglycerides, plasmalogens, or sphingomyelins), the major form of lipid in cell membranes.
C41556	Substrate_Interaction	Molecular_Interaction	Substrate Interaction	Substrate Interaction involves temporary non-covalent binding through intermolecular physical forces of attraction and spatial complementarity between biological molecules, usually proteins, that possess catalytic activity and a target molecule upon which the enzyme produces a chemical or topological transformation.
C41557	Intracellular_Communication_Induction	Cell_Signaling_Process	Intracellular Communication Induction	Intracellular Communication Induction involves initiation of activities that propagate information from one location to another within a cell.
C41558	Intracellular_Communication_Inhibition	Cell_Signaling_Process	Intracellular Communication Inhibition	Intracellular Communication Inhibition involves interference with, or restraint of, activities that propagate information from one location to another within a cell.
C41559	Glucocorticoid_Secretion_Induction	Endocrine_Secretory_Induction	Glucocorticoid Secretion Induction	Glucocorticoid Secretion Induction consists of initiation of activities involved in release into the bloodstream by the adrenal cortex of a class of steroid substances (glucocorticoids) that affect fat, protein, and carbohydrate metabolism (gluconeogenesis, liver glycogen deposition, elevation of blood sugar); inhibit corticotropin secretion; possess anti-inflammatory activity; and play a role in arterial blood pressure, connective tissue response to injury, reduction of circulating lymphocytes, and central nervous system function. Alteration of positive or negative feedback mechanisms can affect hormone release.
C41560	Melatonin_Secretion_Induction	Endocrine_Secretory_Induction	Melatonin Secretion Induction	Melatonin Secretion Induction involves initiation of activities involved in release into the bloodstream from the pineal gland of a hormone (melatonin) implicated in regulation of sleep, mood, puberty, and ovarian cycles.
C41561	Gastric_Acid_Secretion_Inhibition	Gastrointestinal_Secretory_Inhibition	Gastric Acid Secretion Inhibition	Gastric Acid Secretion Inhibition involves interference with, or restraint of, hydrochloric acid release from gastric cells into the lumen of the stomach. Suppression decreases release of pepsinogen and inactivation of ingested microorganisms.
C41562	Gastric_Mucous_Secretion_Inhibition	Gastrointestinal_Secretory_Inhibition	Gastric Mucus Secretion Inhibition	Gastric Mucus Secretion Inhibition involves interference with, or restraint of, mucus release from gastric cells into the lumen of the stomach. Suppression decreases mucous protection and lubrication of the stomach.
C41563	Gastric_Mucous_Secretion_Induction	Gastrointestinal_Secretory_Induction	Gastric Mucus Secretion Induction	Gastric Mucus Secretion Induction involves stimulation of mucus release from gastric cells into the lumen of the stomach. Stimulation promotes mucous protection and lubrication of the stomach.
C41564	Enzyme_Induction	Enzyme_Activity_Alteration	Enzyme Induction	Enzyme Induction involves initiation of function of a biological molecule (usually protein, RNA, or DNA) that possesses catalytic activity.
C41565	Amyloid_Fibril_Interaction	Molecular_Interaction	Amyloid Fibril Interaction	Amyloid Fibril Interaction involves temporary non-covalent binding of a molecule through intermolecular physical forces of attraction with insoluble forms of a secretase-processed metal ion-binding type I cell surface glycoprotein (APP Family) required for endocytosis and BaSS sorting; important in developing synapses, for cell mobility, adhesion, and axonogenesis; and Notch signaling inhibitor, copper homeostasis regulator, transcription activator, and apoptosis enhancer.
C41566	Amyloid_Resorption_Induction	Metabolic_Process	Amyloid Resorption Induction	Amyloid Resorption Induction involves initiation of activities of involved in the breakdown and assimilation of amyloid deposits.
C41567	Antigen_Targeting	Biochemical_Process	Antigen Targeting	Antigen Targeting involves specific and high affinity non-covalent interaction (binding) of an antibody reagent through intermolecular physical forces of attraction and spatial complementarity with a soluble or particulate substance (antigen) that induces an immune response. Using the keen specificity of antigen recognition by antibodies, targeting selectively localizes antibody-associated reagents to antigen sites for therapeutic or diagnostic effect.
C41568	Base_Pair_Miscoding	Mutation	Base Pair Miscoding	Base Pair Miscoding involves flawed activity of biologic molecules or complexes that incorporate incorrect non-complementary paired nucleotides (base pairs) between the linear polymeric antiparallel double helical DNA strands during replication (typically), repair, or rearrangement. The antiparallel double helical strands contain phosphate-linked deoxyribose units in N-glycosidic linkage with heterocyclic nitrogenous pyrimidine (cytosine, thymine) or purine (adenine, guanine) bases lying internal and perpendicular to the axis; complementary adenine-thymine or cytosine-guanine base pairs on the adjacent strands hydrogen bond. In a transition point mutation, a purine base replaces a purine base, or a pyrimidine base replaces a pyrimidine base. In a transversion point mutation a purine base replaces a pyrimidine base, or vice versa.
C41569	Beta_Radiation_Effect	Genotoxic_Stress	Beta Radiation Effect	A Beta Radiation Effect involves biological damage caused by beta particles emitted from a radioactive source. Beta particle energy causes breakage of chemical bonds and ion formation in molecules, such as DNA and RNA, resulting in cell death or damage.
C41570	Calcium_Channel_Inhibition	Protein_Inhibition	Calcium Channel Inhibition	Calcium Channel Inhibition involves interference with, or restraint of, the activities of cell membrane glycoproteins selectively permeable to calcium ions.
C41571	Chaperone_Protein_Inhibition	Protein_Inhibition	Chaperone Protein Inhibition	Chaperone Protein Inhibition involves interference with, or restraint of, the activities of diverse cellular proteins that noncovalently bind to nascent or unfolded polypeptides and mediate assembly/disassembly, stability, and transmembrane translocation of other polypeptides or complexes, but which are not components of those structures.
C41572	Complement-Dependent_Cytotoxicity	Cytolysis_Induction	Complement-Dependent Cytotoxicity	Activated by cell-surface bound antibody, by immune complexes, or by microbial membrane carbohydrate, Complement-Dependent Cytotoxicity involves complex cascades (classical or properdin pathway) of sequentially interacting serum proteins (some serine proteases), their receptors, and related regulatory proteins that generate Membrane Attack Complex, which creates target cell pores and lysis.
C41573	Covalent_Interaction	Biophysical_Process	Covalent Interaction	A Covalent Interaction is a non-enzymatic physical connection between two atoms or radicals in which a chemical bond is formed by sharing electrons.
C41574	Depurination	Biochemical_Reaction	Depurination	Depurination involves cleavage of the N-glycosidic link between a purine base and the remaining deoxyribose portion of the effected nucleotide in DNA, leading to loss of the purine base while leaving the DNA backbone intact. Depurination must be enzymically repaired to ensure genetic stability; transversion mutations result from purine loss.
C41575	Detoxification_Process	Metabolic_Process	Detoxification Process	A Detoxification Process consists of activities of biologic molecules, complexes, or subcellular components involved in reducing the pharmacologic activity or toxicity of a drug or other foreign substance, typically by enzymatic transformations that make a substance more soluble for faster renal excretion.
C41576	DNA_Synthesis_Rescue	DNA_Synthesis_Induction	DNA Synthesis Rescue	DNA Synthesis Rescue involves resumption of DNA synthesis, polymeric linkage of deoxyribonucleotides by phosphate linkage, following arrest of DNA synthesis due to DNA damage. One rescue mechanism involves activation of proteins involved in DNA repair.
C41577	Drug_Metabolism_Alteration	Detoxification_Process	Drug Metabolism Alteration	Drug Metabolism Alteration involves a change in the quality of the existing state of enzymatic biotransforming chemical modifications exerted on a naturally occurring or synthetically produced organic or inorganic substances, elements, and isotopes used in research or for prevention, diagnosis, and /or treatment of disease states.
C41578	Drug_Metabolism_Induction	Drug_Metabolism_Alteration	Drug Metabolism Induction	Drug Metabolism Induction involves the initiation of enzymatic biotransforming chemical modifications exerted on a naturally occurring or synthetically produced organic or inorganic substances, elements, and isotopes used in research or for prevention, diagnosis, and /or treatment of disease states.
C41579	Drug_Metabolism_Inhibition	Drug_Metabolism_Alteration	Drug Metabolism Inhibition	Drug Metabolism Inhibition involves interference with, or restraint of, enzymatic biotransforming chemical modifications exerted on a naturally occurring or synthetically produced organic or inorganic substances, elements, and isotopes used in research or for prevention, diagnosis, and /or treatment of disease states.
C41580	Extracellular_Matrix_Degradation	Biochemical_Process	Extracellular Matrix Degradation	Extracellular Matrix Degradation consists of conjugation, transport, oxidation, and/or proteolysis of the supporting meshwork-like network of fibers and substances in the extracellular space or basement membrane to which cells adhere and that promotes cell proliferation. Extracellular Matrix is broken down during normal physiological and disease processes such as bone remodeling, embryogenesis, cancer, and arthritis.
C41581	Farnesylation_Inhibition	Isoprenylation_Inhibition	Farnesylation Inhibition	Farnesylation Inhibition involves interference with, or restraint of, enzymatic activities involved in covalent addition of farnesyl group(s) (three isoprene units) to polypeptide chains that contain the C terminal motif CAAX after assembly from messenger RNA at the ribosome.
C41582	Farnysylation	Isoprenylation	Farnysylation	A likely membrane attachment device, Farnesylation involves enzymatic covalent addition of farnesyl group(s) (three isoprene units) to polypeptide chains that contain the C terminal motif CAAX after assembly from messenger RNA at the ribosome. The addition involves cleavage and addition to the SH group of C, the free carboxylate group is also methylated.
C41583	Free_Radical_Alteration	Biochemical_Reaction	Free Radical Alteration	Free Radical Alteration involves a change in the quality of the existing cellular state of production in normal or pathological processes of chemically unstable, short half-life and highly reactive molecules carrying at least one unpaired or 'free' electron in the outermost electron shell. Appropriating electron(s) from a nearby molecule and damaging that molecule by altering the electron number in its outermost electron shell, Free Radicals produce tissue damage.
C41584	Free_Radical_Suppression	Free_Radical_Alteration	Free Radical Suppression	Free Radical Suppression involves interference with, or restraint of, production in normal or pathological processes of chemically unstable, short half-life and highly reactive molecules carrying at least one unpaired or 'free' electron in the outermost electron shell. Appropriating electron(s) from a nearby molecule and damaging that molecule by altering the electron number in its outermost electron shell, Free Radicals produce tissue damage.
C41585	Integrin_Inhibition	Receptor_Inhibition	Integrin Inhibition	Integrin Inhibition involves interference with, or restraint of, the activities of a family of noncovalent heterodimeric transmembrane glycoprotein signal transduction receptors for fibronectin, laminin, and other adhesive extracellular matrix glycoproteins, complement, and other cells. Different alpha and beta complexes vary in ligand-specificity and the intracellular domains interact with cytoskeleton.
C41586	Isoprenylation_Inhibition	Post-Translational_Modification_Alteration	Isoprenylation Inhibition	Isoprenylation Inhibition involves interference with, or restraint of, enzymatic activities involved in covalent addition of prenyl and multiprenyl residues to polypeptide chains after assembly from messenger RNA at the ribosome.
C41587	Metabolite_Interaction	Biophysical_Process	Metabolite Interaction	Metabolite Interaction involves a biophysical interaction with a biological metabolite.
C41588	Microtubule_Disassembly_Inhibition	Microtubule_Alteration	Microtubule Disassembly Inhibition	Microtubule Disassembly Inhibition consists of interference with, or restraint of, activities that dismantle the filamentous tubes of variable length in the cytoskeleton composed primarily of conserved alpha, beta, and gamma tubulin that support movement of chromosomes or chromatids during mitosis and meiosis; and give shape, structure, and organization to the cytoplasm and to a cell.
C41589	Microtubule_Stabilization	Microtubule_Alteration	Microtubule Stabilization	Microtubule Stabilization consists of activities involved in maintenance of filamentous tubes of variable length in the cytoskeleton composed primarily of conserved alpha, beta, and gamma tubulin that support movement of chromosomes or chromatids during mitosis and meiosis; and give shape, structure, and organization to the cytoplasm and to a cell.
C41590	Nephrotoxicity_Inhibition	Cell_Viability_Process	Nephrotoxicity Inhibition	Nephrotoxicity Inhibition involves interference with, or restraint of, the activities of an agent, a biologic molecule or complex, or a cell having toxic or destructive action on kidney cells.
C41591	Nucleic_Acid_Cleavage	Biochemical_Process	Nucleic Acid Cleavage	Nucleic Acid Cleavage involves a process of enzymatically cutting by the addition of a water molecule to high molecular weight polymers of purine and pyrimidine nucleotides covalently bound by ribose or deoxyribose linkages.
C41592	Nucleotide_Synthesis_Inhibition	Nucleotide_Synthesis_Alteration	Nucleotide Synthesis Inhibition	Nucleotide Synthesis Inhibition involves interference with, or restraint of, the activities of biologic molecules or complexes involved in the enzymatic formation of nucleoside phosphates, the monomeric building blocks from which DNA or RNA polymers are constructed that consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group.
C41593	Oxidation-Reduction_Interaction	Biophysical_Process	Oxidation-Reduction Interaction	An Oxidation-Reduction Interaction is a non-enzymatic physical interaction between atoms or radicals in which the positive charges on an atom increase (or the negative charges on that atom decrease) while the negative charges on the other atom increase (or the positive charges on that other atom decrease).
C41594	Phosphorylation_Inhibition	Biochemical_Process	Phosphorylation Inhibition	Phosphorylation Inhibition involves interference with, or restraint of, the enzymatic creation of a phosphate derivative of an organic molecule; often by transfer of a phosphate group from ATP via the action of a kinase.
C41595	Post-Translational_Modification_Alteration	Post-Translational_Regulation	Post-Translational Modification Alteration	Post-Translational Modification Alteration involves a change in the quality of the existing state of biosynthetic enzymatic reactions that occur after polypeptide chain assembly from messenger RNA at the ribosome.
C41596	Proteasome_Binding	Molecular_Interaction	Proteasome Binding|Proteasome Interaction	Proteasome Binding involves temporary non-covalent interaction through intermolecular physical forces of attraction with multicatalytic macromolecular cellular structures in the cytosol and nucleus with multiple proteolytic activities involved in ATP-dependent ubiquitinated protein degradation and antigen processing.
C41597	Proteasome_Inhibition	Protein_Inhibition	Proteasome Function Inhibition|Proteasome Inhibition	Proteasome Inhibition involves interference with, or restraint of, the activities of macromolecular multicatalytic cellular structures in the cytosol and nucleus with multiple proteolytic activities involved in ATP-dependent ubiquitinated protein degradation and antigen processing.
C41598	Protein_Cleavage	Post-Translational_Modification	Protein Cleavage	Protein Cleavage involves hydrolysis by proteolytic enzymes of specific peptide bond(s), forming smaller polypeptides in the target protein during maturation or modification of functional activity.
C41599	Protein_Inhibition	Biochemical_Process	Protein Inhibition	Protein Inhibition involves interference with, or restraint of, the activities of the group of complex organic macromolecules composed of at least one chain (linear polymer) of alpha-L-amino acids linked by peptide bonds and ranging in size from a few thousand to over 1 million Daltons. Proteins are genetically encoded components of living cells with specific structures and functions dictated by amino acid sequence and include diverse functional classes such as enzymes, hormones, receptors, and antibodies.
C41600	Protein_Phosphorylation_Inhibition	Post-Translational_Modification_Alteration	Protein Phosphorylation Inhibition	Protein Phosphorylation Inhibition involves interference with, or restraint of, enzymatic activities involved in covalent transfer of a phosphate group from ATP to a protein via the action of a kinase. The major phosphoryl acceptors in proteins are serine, threonine, and tyrosine. Typically, such post-translational modifications regulate protein function.
C41601	Radiation_Interaction	Biophysical_Process	Radiation Interaction	Radiation Interaction involves the interaction of a stream of subatomic particles or transmitted energy waves (such as electromagnetic radiation) with a biological component.
C41602	Ribosome_Inactivation	Ribosomal_Function_Inhibition	Ribosome Inactivation	Ribosome Inactivation involves interference with, or restraint of, the activity of small 120-150A diameter cytoplasmic ribonucleoprotein organelles composed of rRNA and some 80 different proteins that, assembled as a complex (free or attached to the ER), constitute the site of protein synthesis from aminoacyl-tRNAs as directed by mRNAs.
C41603	Desmoplastic	Disease_Morphology_Modifier	Desmoplastic|Desmoplastic Reaction	This term refers to the growth of fibrous or connective tissue. Some tumors elicit a desmoplastic reaction, the pervasive growth of dense fibrous tissue around the tumor. Scar tissue (adhesion) within the abdomen after abdominal surgery is another type of desmoplastic reaction. (MedicineNet.com)
C41604	Specimen_Processing	Clinical_or_Research_Activity	Specimen Processing	The process of preparing a sample or portion of a sample for storage, preservation, or further analysis.
C41605	Neoplastic_Mesothelial_Cell	Abnormal_Mesothelial_Cell|Neoplastic_Cell	Neoplastic Mesothelial Cell
C41607	Ovarian_Granulosa_Cell	Follicular_Ovarian_Cell|Granulosa_Cell	Ovarian Granulosa Cell	A cuboidal cell derived from a spindle-shaped granulosa cell precursor. Initially, ovarian granulosa cells create a single layer surrounding an oocyte. The oocyte and its single layer of ovarian granulosa cells make up a primary follicle. Proliferation of the ovarian granulosa cells leads to multiple cell layers surrounding the oocyte and maturation into a secondary follicle. The granulosa cells extend cytoplasmic processes to form gestational gap-junction-like unions with the plasma membrane of the oocyte. The continued growth of the ovarian granulosa cells takes the oocyte to the Graafian follicle stage. Once ovulation occurs, the granulosa cells become part of the corpus luteum. A major function of an ovarian granulosa cell is hormone production and secretion.
C41608	Endocrine-Stromal_Cell	Secretory_Cell	Endocrine-Stromal Cell	A cell that forms the supporting matrix of one of the glands that secretes substances into the blood or lymph.
C41609	Endocrine_Reproductive_Tissue	Tissue	Endocrine Reproductive Tissue
C41610	Mixed_Cellular_Population	Cellular_Infiltrate	Mixed Cellular Population
C41611	Cellular_Origin_Unknown	Lab_Finding	Precise Histogenesis Unknown
C41612	Extensive_Necrosis	Necrotic_Change	Extensive Necrosis
C41613	CDKN2C_Gene_Mutation	Gene_Abnormality	CDKN2C Gene Mutation
C41614	CDKN2C_Gene_Deletion	Chromosomal_Deletion	CDKN2C Gene Deletion
C41615	CDKN2A_Gene_Deletion	Chromosomal_Deletion	CDKN2A Gene Deletion
C41617	Cholangiolocellular_Carcinoma	Intrahepatic_Cholangiocarcinoma	Cholangiolocellular Carcinoma
C41618	Mucinous_Intrahepatic_Cholangiocarcinoma	Intrahepatic_Cholangiocarcinoma|Mucinous_Adenocarcinoma	Mucinous Intrahepatic Cholangiocarcinoma
C41619	Signet_Ring_Cell_Intrahepatic_Cholangiocarcinoma	Intrahepatic_Cholangiocarcinoma|Signet_Ring_Cell_Carcinoma	Signet Ring Cell Intrahepatic Cholangiocarcinoma
C41620	Sarcomatous_Intrahepatic_Cholangiocarcinoma	Intrahepatic_Cholangiocarcinoma	Sarcomatous Intrahepatic Cholangiocarcinoma
C41621	Nucleotide_Metabolism_Alteration	Nucleotide_Metabolism	Nucleotide Metabolism Alteration	Nucleotide Metabolism Alteration involves a change in the quality of the existing state of activities of biologic molecules or complexes involved in the enzymatic formation or degradation of nucleoside phosphates, the monomeric building blocks from which DNA or RNA polymers are constructed that consist of a purine or pyrimidine base, a pentose sugar, and a phosphate group.
C41622	Iron_Uptake_Inhibition	Cellular_Transport_Alteration	Iron Uptake Inhibition	Iron Uptake Inhibition involves interference with, or restraint of, subcellular or molecular processes directly involved in the physical translocation from the extracellular to intracellular compartment of the metallic element Iron, which forms part of hemoglobin and enzyme systems essential for energy metabolism.
C41623	Ependyma_and_Remnants_of_the_Central_Canal_of_the_Spinal_Cord	Membrane_of_the_Brain_or_Spinal_Cord|Neuroepithelial_Tissue	Ependyma and Remnants of the Central Canal of the Spinal Cord	Structures that have evolved from embryonic development of the neural tube. The ependyma is a specialised epithelium lining the ventricles and central canal of the brain and spinal cord. The remnants of the central canal of the spinal cord represent modified ependyma left from embryonic development of the neural tube
C41624	Remnants_of_the_Central_Canal_of_the_Spinal_Cord	Ependyma_and_Remnants_of_the_Central_Canal_of_the_Spinal_Cord	Remnants of the Central Canal of the Spinal Cord	A solid strand of modified ependyma left from embryonic development of the neural tube.
C41625	Protein_Kinase_B	Serine-Threonine_Protein_Kinase	Protein Kinase B|AKT	Expressed in diverse tissues, Protein Kinase B (AKT/RAC Family) is a group (Alpha, Beta and Gamma) of cytoplasmic serine/threonine enzymes that covalently transfer the terminal, gamma phosphate group from ATP to a variety of substrate proteins and regulate cell signaling responses to insulin, PDGF, and IGF1 (through PI3K) involved in cell survival, cell proliferation, differentiation, apoptosis, glycogen synthesis, and glucose uptake.
C41626	Perivascular_Pseudorosette_Formation	Pseudorosette_Formation	Perivascular Pseudorosette Formation
C41627	Non-Voltage-Dependent_Calcium_Channel	Ion_Channel_Protein	Non-Voltage-Dependent Calcium Channel	Non-Voltage-Dependent Calcium Channels are membrane-associated protein-based structures that regulate the movement of calcium ions through cellular membranes, independent of the transmembrane potential gradient, to affect cellular homeostatic conditions and/or signaling processes.
C41628	DNA_Methyltransferase	Methyltransferase	DNA Methyltransferase	DNA Methyltransferases are a subclass of transferase enzymes that catalyze the transfer of a methyl group from a donor compound to DNA.
C41629	Clear_Perinuclear_Halo_Present	Morphologic_Finding	Clear Perinuclear Halo Present
C41630	Fascicles_of_Spindly_Tumor_Cells_Present	Abnormal_Cells_Present	Fascicles of Spindly Tumor Cells Present
C41631	_7_86987215-86777599	Chromosome_7_Physical_Location	7: 86987215-86777599	Physical location of ABCB1_Gene
C41632	_2_219909177-219899999	Chromosome_2_Physical_Location	2: 219909177-219899999	Physical location of ABCB6_Gene
C41633	_16_15950935-16143774	Chromosome_16_Physical_Location	16: 15950935-16143774	Physical location of ABCC1_Gene
C41634	_4_89436901-893700019	Chromosome_4_Physical_Location	4: 89436901-893700019	Physical location of ABCG2_Gene
C41635	_2_204018668-204117838	Chromosome_2_Physical_Location	2: 204018668-204117838	Physical location of ABI2_Gene
C41636	_9_130619261-130792614	Chromosome_9_Physical_Location	9: 130619261-130792614	Physical location of ABL1_Gene
C41637	_1_175930393-175808414	Chromosome_1_Physical_Location	1: 175930393-175808414	Physical location of ABL2_Gene
C41638	_3_197124265-197078545	Chromosome_3_Physical_Location	3: 197124265-197078545	Physical location of ACK1_Gene
C41639	_3_133518957-133560302	Chromosome_3_Physical_Location	3: 133518957-133560302	Physical location of ACPP_Gene
C41640	_12_6626841-6617503	Chromosome_12_Physical_Location	12: 6626841-6617503	Physical location of ACRBP_Gene
C41641	_4_186122364-186051899	Chromosome_4_Physical_Location	4: 186122364-186051899	Physical location of ACSL1_Gene
C41642	_2_74031790-74058434	Chromosome_2_Physical_Location	2: 74031790-74058434	Physical location of ACTG2_Gene
C41643	_2_158500579-158418469	Chromosome_2_Physical_Location	2: 158500579-158418469	Physical location of ACVR1_Gene
C41644	_12_50631753-50677127	Chromosome_12_Physical_Location	12: 50631753-50677127	Physical location of ACVR1B_Gene
C41645	_2_148436296-148519244	Chromosome_2_Physical_Location	2: 148436296-148519244	Physical location of ACVR2_Gene
C41646	_3_384700814-38499868	Chromosome_3_Physical_Location	3: 384700814-38499868	Physical location of ACVR2B_Gene
C41647	_12_50587469-50601120	Chromosome_12_Physical_Location	12: 50587469-50601120	Physical location of ACVRL1_Gene
C41648	_20_42723790-42681578	Chromosome_20_Physical_Location	20: 42723790-42681578	Physical location of ADA_Gene
C41649	_17_40192094-40213504	Chromosome_17_Physical_Location	17: 40192094-40213504	Physical location of ADAM11_Gene
C41650	_1_151836835-151848325	Chromosome_1_Physical_Location	1: 151836835-151848325	Physical location of ADAM15_Gene
C41651	_21_27239386-27130479	Chromosome_21_Physical_Location	21: 27239386-27130479	Physical location of ADAMTS1_Gene
C41652	_3_64648405-64476373	Chromosome_3_Physical_Location	3: 64648405-64476373	Physical location of ADAMTS9_Gene
C41653	_16_4105460-3954907	Chromosome_16_Physical_Location	16: 4105460-3954907	Physical location of ADCY9_Gene
C41654	_1_199791439-199868189	Chromosome_1_Physical_Location	1: 199791439-199868189	Physical location of ADORA1_Gene
C41655	_22_23153646-23162879	Chromosome_22_Physical_Location	22: 23153646-23162879	Physical location of ADORA2A_Gene
C41656	_17_15788956-15819935	Chromosome_17_Physical_Location	17: 15788956-15819935	Physical location of ADORA2B_Gene
C41657	_1_111758785-111754097	Chromosome_1_Physical_Location	1: 111758785-111754097	Physical location of ADORA3_Gene
C41658	_8_26778839-26661584	Chromosome_8_Physical_Location	8: 26778839-26661584	Physical location of ADRA1A_Gene
C41659	_5_159276318-159332129	Chromosome_5_Physical_Location	5: 159276318-159332129	Physical location of ADRA1B_Gene
C41660	_10_112826911-112830560	Chromosome_10_Physical_Location	10: 112826911-112830560	Physical location of ADRA2A_Gene
C41661	_2_96203762-96200497	Chromosome_2_Physical_Location	2: 96203762-96200497	Physical location of ADRA2B_Gene
C41662	_10_115793796-115795518	Chromosome_10_Physical_Location	10: 115793796-115795518	Physical location of ADRB1_Gene
C41663	_5_148186369-148188379	Chromosome_5_Physical_Location	5: 148186369-148188379	Physical location of ADRB2_Gene
C41664	_11_66790663-66810945	Chromosome_11_Physical_Location	11: 66790663-66810945	Physical location of ADRBK1_Gene
C41665	_22_24285500-24444470	Chromosome_22_Physical_Location	22: 24285500-24444470	Physical location of ADRBK2_Gene
C41666	_5_132327181-132244244	Chromosome_5_Physical_Location	5: 132327181-132244244	Physical location of AF5Q31_Gene
C41667	_4_74666968-74686527	Chromosome_4_Physical_Location	4: 74666968-74686527	Physical location of AFP_Gene
C41668	_7_16617848-16604676	Chromosome_7_Physical_Location	7: 16617848-16604676	Physical location of AGR2_Gene
C41669	_1_227156602-227145020	Chromosome_1_Physical_Location	1: 227156602-227145020	Physical location of AGT_Gene
C41670	_X_115113885-115117702	Chromosome_X_Physical_Location	X: 115113885-115117702	Physical location of AGTR2_Gene
C41671	_7_17111486-17158632	Chromosome_7_Physical_Location	7: 17111486-17158632	Physical location of AHR_Gene
C41672	_6_106915002-107125017	Chromosome_6_Physical_Location	6: 106915002-107125017	Physical location of AIM1_Gene
C41673	_1_155859720-155845348	Chromosome_1_Physical_Location	1: 155859720-155845348	Physical location of AIM2_Gene
C41674	_6_151653623-151770023	Chromosome_6_Physical_Location	6: 151653623-151770023	Physical location of AKAP12_Gene
C41675	_15_83724875-840-93590	Chromosome_15_Physical_Location	15: 83724875-840-93590	Physical location of AKAP13_Gene
C41676	_7_91214843-91384640	Chromosome_7_Physical_Location	7: 91214843-91384640	Physical location of AKAP9_Gene
C41677	_1_19383946-19375770	Chromosome_1_Physical_Location	1: 19383946-19375770	Physical location of AKR7A2_Gene
C41678	_14_104330732-104306753	Chromosome_14_Physical_Location	14: 104330732-104306753	Physical location of AKT1_Gene
C41679	_19_45483036-45431556	Chromosome_19_Physical_Location	19: 45483036-45431556	Physical location of AKT2_Gene
C41680	_1_240332594-239977576	Chromosome_1_Physical_Location	1: 240332594-239977576	Physical location of AKT3_Gene
C41681	_3_106568880-106776709	Chromosome_3_Physical_Location	3: 106568880-106776709	Physical location of ALCAM_Gene
C41682	_15_56145198-56032919	Chromosome_15_Physical_Location	15: 56145198-56032919	Physical location of ALDH1A2_Gene
C41683	_2_48756599-48871936	Chromosome_2_Physical_Location	2: 48756599-48871936	Physical location of ALF_Gene
C41684	_2_30056083-29327293	Chromosome_2_Physical_Location	2: 30056083-29327293	Physical location of ALK_Gene
C41685	_17_4491709-4480965	Chromosome_17_Physical_Location	17: 4491709-4480965	Physical location of ALOX15_Gene
C41686	_16_55016804-54952865	Chromosome_16_Physical_Location	16: 55016804-54952865	Physical location of AMFR_Gene
C41687	_12_52103908-52111579	Chromosome_12_Physical_Location	12: 52103908-52111579	Physical location of AMHR2_Gene
C41688	_7_38444260-38196547	Chromosome_7_Physical_Location	7: 38444260-38196547	Physical location of AMPH_Gene
C41689	_2_73967741-74001666	Chromosome_2_Physical_Location	2: 73967741-74001666	Physical location of AMSH_Gene
C41690	_14_20222609-20232185	Chromosome_14_Physical_Location	14: 20222609-20232185	Physical location of ANG_Gene
C41691	_8_108579430-108330886	Chromosome_8_Physical_Location	8: 108579430-108330886	Physical location of ANGPT1_Gene
C41692	_8_6408172-6347601	Chromosome_8_Physical_Location	8: 6408172-6347601	Physical location of ANGPT2_Gene
C41693	_9_97825196-97857776	Chromosome_9_Physical_Location	9: 97825196-97857776	Physical location of ANP32B_Gene
C41694	_4_165476468-165475764	Chromosome_4_Physical_Location	4: 165476468-165475764	Physical location of ANP32C_Gene
C41695	_12_47152715-47153110	Chromosome_12_Physical_Location	12: 47152715-47153110	Physical location of ANP32D_Gene
C41696	_4_122975781-122946753	Chromosome_4_Physical_Location	4: 122975781-122946753	Physical location of ANXA5_Gene
C41697	_10_47127013-47233044	Chromosome_10_Physical_Location	10: 47127013-47233044	Physical location of ANXA8_Gene
C41698	_12_97541546-97631679	Chromosome_12_Physical_Location	12: 97541546-97631679	Physical location of APAF1_Gene
C41699	_5_112118469-112209533	Chromosome_5_Physical_Location	5: 112118469-112209533	Physical location of APC_Gene
C41700	_19_1402288-1424237	Chromosome_19_Physical_Location	19: 1402288-1424237	Physical location of APCL_Gene
C41701	_3_49686439-49695938	Chromosome_3_Physical_Location	3: 49686439-49695938	Physical location of APEH_Gene
C41702	_14_19993130-19995766	Chromosome_14_Physical_Location	14: 19993130-19995766	Physical location of APEX1_Gene
C41703	_X_54909801-54917233	Chromosome_X_Physical_Location	X: 54909801-54917233	Physical location of APEXL2_Gene
C41704	_21_26465003-26174733	Chromosome_21_Physical_Location	21: 26465003-26174733	Physical location of APP_Gene
C41705	_17_55958362-55875302	Chromosome_17_Physical_Location	17: 55958362-55875302	Physical location of APPBP2_Gene
C41706	_13_32058624-32250157	Chromosome_13_Physical_Location	13: 32058624-32250157	Physical location of APRIN_Gene
C41707	_16_87405879-87403380	Chromosome_16_Physical_Location	16: 87405879-87403380	Physical location of APRT_Gene
C41708	_7_101521887-101555613	Chromosome_7_Physical_Location	7: 101521887-101555613	Physical location of APS_Gene
C41709	_X_66546895-66727140	Chromosome_X_Physical_Location	X: 66546895-66727140	Physical location of AR_Gene
C41710	_X_47176761-47187553	Chromosome_X_Physical_Location	X: 47176761-47187553	Physical location of ARAF1_Gene
C41711	_4_75675888-75685761	Chromosome_4_Physical_Location	4: 75675888-75685761	Physical location of AREG_Gene
C41712	_3_49424403-49371582	Chromosome_3_Physical_Location	3: 49424403-49371582	Physical location of ARHA_Gene
C41713	_2_20568463-20570829	Chromosome_2_Physical_Location	2: 20568463-20570829	Physical location of ARHB_Gene
C41714	_1_112961762-112955795	Chromosome_1_Physical_Location	1: 112961762-112955795	Physical location of ARHC_Gene
C41715	_19_47079107-47103444	Chromosome_19_Physical_Location	19: 47079107-47103444	Physical location of ARHGEF1_Gene
C41716	_7_143500552-143515372	Chromosome_7_Physical_Location	7: 143500552-143515372	Physical location of ARHGEF5_Gene
C41717	_4_40021168-40068421	Chromosome_4_Physical_Location	4: 40021168-40068421	Physical location of ARHH_Gene
C41718	_1_68228334-68223668	Chromosome_1_Physical_Location	1: 68228334-68223668	Physical location of ARHI_Gene
C41719	_3_51397518-51401815	Chromosome_3_Physical_Location	3: 51397518-51401815	Physical location of ARMET_Gene
C41720	_1_147662259-147595259	Chromosome_1_Physical_Location	1: 147662259-147595259	Physical location of ARNT_Gene
C41721	_15_78483887-78677329	Chromosome_15_Physical_Location	15: 78483887-78677329	Physical location of ARNT2_Gene
C41722	_11_74678732-74654811	Chromosome_11_Physical_Location	11: 74678732-74654811	Physical location of ARRB1_Gene
C41723	_19_50651307-50605864	Chromosome_19_Physical_Location	19: 50651307-50605864	Physical location of ASE-1_Gene
C41724	_7_87150195-87183507	Chromosome_7_Physical_Location	7: 87150195-87183507	Physical location of ASK_Gene
C41725	_2_175858404-175763515	Chromosome_2_Physical_Location	2: 175858404-175763515	Physical location of ATF2_Gene
C41726	_11_107599053-107741971	Chromosome_11_Physical_Location	11: 107599053-107741971	Physical location of ATM_Gene
C41727	_13_24941115-25492996	Chromosome_13_Physical_Location	13: 24941115-25492996	Physical location of ATP8A2_Gene
C41728	_3_143780349-143650778	Chromosome_3_Physical_Location	3: 143780349-143650778	Physical location of ATR_Gene
C41729	_9_91203730-91055664	Chromosome_9_Physical_Location	9: 91203730-91055664	Physical location of AUH_Gene
C41730	_20_3014058-3011186	Chromosome_20_Physical_Location	20: 3014058-3011186	Physical location of AVP_Gene
C41731	_12_61832857-61826483	Chromosome_12_Physical_Location	12: 61832857-61826483	Physical location of AVPR1A_Gene
C41732	_1_202767011-202774706	Chromosome_1_Physical_Location	1: 202767011-202774706	Physical location of AVPR1B_Gene
C41733	_X_152691217-152693487	Chromosome_X_Physical_Location	X: 152691217-152693487	Physical location of AVPR2_Gene
C41734	_16_342465-277441	Chromosome_16_Physical_Location	16: 342465-277441	Physical location of AXIN1_Gene
C41735	_17_60985289-60956106	Chromosome_17_Physical_Location	17: 60985289-60956106	Physical location of AXIN2_Gene
C41736	_19_46416663-46459511	Chromosome_19_Physical_Location	19: 46416663-46459511	Physical location of AXL_Gene
C41737	_19_778831-783017	Chromosome_19_Physical_Location	19: 778831-783017	Physical location of AZU1_Gene
C41738	_11_63808740-63793878	Chromosome_11_Physical_Location	11: 63808740-63793878	Physical location of BAD_Gene
C41739	_9_33254737-33245026	Chromosome_9_Physical_Location	9: 33254737-33245026	Physical location of BAG1_Gene
C41740	_8_38153263-38187694	Chromosome_8_Physical_Location	8: 38153263-38187694	Physical location of BAG4_Gene
C41741	_14_103098383-103093192	Chromosome_14_Physical_Location	14: 103098383-103093192	Physical location of BAG5_Gene
C41742	_8_143542379-143623370	Chromosome_8_Physical_Location	8: 143542379-143623370	Physical location of BAI1_Gene
C41743	_1_31898729-31861812	Chromosome_1_Physical_Location	1: 31898729-31861812	Physical location of BAI2_Gene
C41744	_6_69404158-7056120	Chromosome_6_Physical_Location	6: 69404158-7056120	Physical location of BAI3_Gene
C41745	_3_65999265-65321090	Chromosome_3_Physical_Location	3: 65999265-65321090	Physical location of BAIAP1_Gene
C41746	_17_76623557-76705827	Chromosome_17_Physical_Location	17: 76623557-76705827	Physical location of BAIAP2_Gene
C41747	_6_33655959-33648307	Chromosome_6_Physical_Location	6: 33655959-33648307	Physical location of BAK1_Gene
C41748	_3_52419049-52410067	Chromosome_3_Physical_Location	3: 52419049-52410067	Physical location of BAP1_Gene
C41749	_2_215499872-215418783	Chromosome_2_Physical_Location	2: 215499872-215418783	Physical location of BARD1_Gene
C41750	_19_54149929-54156867	Chromosome_19_Physical_Location	19: 54149929-54156867	Physical location of BAX_Gene
C41751	_19_63758298-63754746	Chromosome_19_Physical_Location	19: 63758298-63754746	Physical location of BC-2_Gene
C41752	_1_231817541-231656253	Chromosome_1_Physical_Location	1: 231817541-231656253	Physical location of BCAA_Gene
C41753	_16_73843004-73820430	Chromosome_16_Physical_Location	16: 73843004-73820430	Physical location of BCAR1_Gene
C41754	_1_93859223-93739372	Chromosome_1_Physical_Location	1: 93859223-93739372	Physical location of BCAR3_Gene
C41755	_20_52120490-51993924	Chromosome_20_Physical_Location	20: 52120490-51993924	Physical location of BCAS1_Gene
C41756	_1_114836302-114822227	Chromosome_1_Physical_Location	1: 114836302-114822227	Physical location of BCAS2_Gene
C41757	_17_65110015-56824974	Chromosome_17_Physical_Location	17: 65110015-56824974	Physical location of BCAS3_Gene
C41758	_20_48844975-49827121	Chromosome_20_Physical_Location	20: 48844975-49827121	Physical location of BCAS4_Gene
C41759	_3_167037952-166973395	Chromosome_3_Physical_Location	3: 167037952-166973395	Physical location of BCHE_Gene
C41760	_1_85455604-85443954	Chromosome_1_Physical_Location	1: 85455604-85443954	Physical location of BCL10_Gene
C41761	_18_59137025-58941558	Chromosome_18_Physical_Location	18: 59137025-58941558	Physical location of BCL2_Gene
C41762	_20_29774317-29715924	Chromosome_20_Physical_Location	20: 29774317-29715924	Physical location of BCL2L1_Gene
C41763	_2_111597541-111640818	Chromosome_2_Physical_Location	2: 111597541-111640818	Physical location of BCL2L11_Gene
C41764	_14_22845866-22850798	Chromosome_14_Physical_Location	14: 22845866-22850798	Physical location of BCL2L2_Gene
C41765	_19_49943871-49955140	Chromosome_19_Physical_Location	19: 49943871-49955140	Physical location of BCL3_Gene
C41766	_3_188946177-188921867	Chromosome_3_Physical_Location	3: 188946177-188921867	Physical location of BCL6_Gene
C41767	_12_120921747-120962668	Chromosome_12_Physical_Location	12: 120921747-120962668	Physical location of BCL7A_Gene
C41768	_1_144237996-144322828	Chromosome_1_Physical_Location	1: 144237996-144322828	Physical location of BCL9_Gene
C41769	_22_21847106-21982698	Chromosome_22_Physical_Location	22: 21847106-21982698	Physical location of BCR_Gene
C41770	_14_95740950-95780542	Chromosome_14_Physical_Location	14: 95740950-95780542	Physical location of BDKRB2_Gene
C41771	_11_27699851-27633020	Chromosome_11_Physical_Location	11: 27699851-27633020	Physical location of BDNF_Gene
C41772	_5_70787261-70877060	Chromosome_5_Physical_Location	5: 70787261-70877060	Physical location of BDP1_Gene
C41773	_22_16631812-16591460	Chromosome_22_Physical_Location	22: 16631812-16591460	Physical location of BID_Gene
C41774	_22_41831255-41850216	Chromosome_22_Physical_Location	22: 41831255-41850216	Physical location of BIK_Gene
C41775	_2_127581094-127521837	Chromosome_2_Physical_Location	2: 127581094-127521837	Physical location of BIN1_Gene
C41776	_5_70352369-70300066	Chromosome_5_Physical_Location	5: 70352369-70300066	Physical location of BIRC1_Gene
C41777	_11_101723176-101754611	Chromosome_11_Physical_Location	11: 101723176-101754611	Physical location of BIRC2_Gene
C41778	_11_101693404-101713675	Chromosome_11_Physical_Location	11: 101693404-101713675	Physical location of BIRC3_Gene
C41779	_X_122719583-122773357	Chromosome_X_Physical_Location	X: 122719583-122773357	Physical location of BIRC4_Gene
C41780	_17_73721944-73732372	Chromosome_17_Physical_Location	17: 73721944-73732372	Physical location of BIRC5_Gene
C41781	_2_32493965-32754622	Chromosome_2_Physical_Location	2: 32493965-32754622	Physical location of BIRC6_Gene
C41782	_20_61337721-61342299	Chromosome_20_Physical_Location	20: 61337721-61342299	Physical location of BIRC7_Gene
C41783	_8_11388930-11459517	Chromosome_8_Physical_Location	8: 11388930-11459517	Physical location of BLK_Gene
C41784	_15_89061606-89159602	Chromosome_15_Physical_Location	15: 89061606-89159602	Physical location of BLM_Gene
C41785	_10_98021316-97941447	Chromosome_10_Physical_Location	10: 98021316-97941447	Physical location of BLNK_Gene
C41786	_11_118259777-118272181	Chromosome_11_Physical_Location	11: 118259777-118272181	Physical location of BLR1_Gene
C41787	_10_22650146-22660194	Chromosome_10_Physical_Location	10: 22650146-22660194	Physical location of BMI1_Gene
C41788	_2_69010300-69004264	Chromosome_2_Physical_Location	2: 69010300-69004264	Physical location of BMP10_Gene
C41789	_X_50486820-50492643	Chromosome_X_Physical_Location	X: 50486820-50492643	Physical location of BMP15_Gene
C41790	_20_6697207-6707769	Chromosome_20_Physical_Location	20: 6697207-6707769	Physical location of BMP2_Gene
C41791	_4_82309298-82331904	Chromosome_4_Physical_Location	4: 82309298-82331904	Physical location of BMP3_Gene
C41792	_6_55848334-55728199	Chromosome_6_Physical_Location	6: 55848334-55728199	Physical location of BMP5_Gene
C41793	_6_7672009-7826724	Chromosome_6_Physical_Location	6: 7672009-7826724	Physical location of BMP6_Gene
C41794	_20_55274708-55178962	Chromosome_20_Physical_Location	20: 55274708-55178962	Physical location of BMP7_Gene
C41795	_1_39923389-39892996	Chromosome_1_Physical_Location	1: 39923389-39892996	Physical location of BMP8_Gene
C41796	_10_88506376-88674925	Chromosome_10_Physical_Location	10: 88506376-88674925	Physical location of BMPR1A_Gene
C41797	_2_203067105-203257980	Chromosome_2_Physical_Location	2: 203067105-203257980	Physical location of BMPR2_Gene
C41798	_X_15278609-15334309	Chromosome_X_Physical_Location	X: 15278609-15334309	Physical location of BMX_Gene
C41799	_8_26296440-26326561	Chromosome_8_Physical_Location	8: 26296440-26326561	Physical location of BNIP3L_Gene
C41800	_6_3064041-3098288	Chromosome_6_Physical_Location	6: 3064041-3098288	Physical location of BPHL_Gene
C41801	_7_140077748-139887463	Chromosome_7_Physical_Location	7: 140077748-139887463	Physical location of BRAF_Gene
C41802	_17_38530934-38449844	Chromosome_17_Physical_Location	17: 38530934-38449844	Physical location of BRCA1_Gene
C41803	_13_31787617-31871805	Chromosome_13_Physical_Location	13: 31787617-31871805	Physical location of BRCA2_Gene
C41804	_6_33044415-33057059	Chromosome_6_Physical_Location	6: 33044415-33057059	Physical location of BRD2_Gene
C41805	_4_68253212-68301377	Chromosome_4_Physical_Location	4: 68253212-68301377	Physical location of BRDG1_Gene
C41806	_14_104838374-104746670	Chromosome_14_Physical_Location	14: 104838374-104746670	Physical location of BRF1_Gene
C41807	_8_37826569-37820563	Chromosome_8_Physical_Location	8: 37826569-37820563	Physical location of BRF2_Gene
C41808	_11_65869132-65861387	Chromosome_11_Physical_Location	11: 65869132-65861387	Physical location of BRMS1_Gene
C41809	_X_135295645-135300118	Chromosome_X_Physical_Location	X: 135295645-135300118	Physical location of BRS3_Gene
C41810	_10_93673716-93779349	Chromosome_10_Physical_Location	10: 93673716-93779349	Physical location of BTAF1_Gene
C41811	_4_7607708-76028627	Chromosome_4_Physical_Location	4: 7607708-76028627	Physical location of BTC_Gene
C41812	_1_200006321-200010387	Chromosome_1_Physical_Location	1: 200006321-200010387	Physical location of BTG2_Gene
C41813	_2_111151853-111111643	Chromosome_2_Physical_Location	2: 111151853-111111643	Physical location of BUB1_Gene
C41814	_22_28274230-28228872	Chromosome_22_Physical_Location	22: 28274230-28228872	Physical location of C22orf19_Gene
C41815	_19_6671660-6628878	Chromosome_19_Physical_Location	19: 6671660-6628878	Physical location of C3_Gene
C41816	_9_120892108-120794170	Chromosome_9_Physical_Location	9: 120892108-120794170	Physical location of C5_Gene
C41817	_6_41857025-41865610	Chromosome_6_Physical_Location	6: 41857025-41865610	Physical location of C6orf49_Gene
C41818	_2_27351909-273738305	Chromosome_2_Physical_Location	2: 27351909-273738305	Physical location of CAD_Gene
C41819	_11_14950427-14946626	Chromosome_11_Physical_Location	11: 14950427-14946626	Physical location of CALCA_Gene
C41820	_14_89933126-89944151	Chromosome_14_Physical_Location	14: 89933126-89944151	Physical location of CALM1_Gene
C41821	_5_134102105-134115746	Chromosome_5_Physical_Location	5: 134102105-134115746	Physical location of CAMLG_Gene
C41822	_11_104411067-104401445	Chromosome_11_Physical_Location	11: 104411067-104401445	Physical location of CASP1_Gene
C41823	_2_201873361-201919616	Chromosome_2_Physical_Location	2: 201873361-201919616	Physical location of CASP10_Gene
C41824	_7_142502239-142521622	Chromosome_7_Physical_Location	7: 142502239-142521622	Physical location of CASP2_Gene
C41825	_4_185945750-185924000	Chromosome_4_Physical_Location	4: 185945750-185924000	Physical location of CASP3_Gene
C41826	_11_104344503-104318805	Chromosome_11_Physical_Location	11: 104344503-104318805	Physical location of CASP4_Gene
C41827	_5_104384909-104370180	Chromosome_5_Physical_Location	5: 104384909-104370180	Physical location of CASP5_Gene
C41828	_4_110982233-110967389	Chromosome_4_Physical_Location	4: 110982233-110967389	Physical location of CASP6_Gene
C41829	Pseudopalisading_Necrosis	Necrotic_Change	Pseudopalisading Necrosis
C41830	Back_Pain	Pain	Back Pain
C41831	Nests_of_Tumor_Cell_Nuclei_in_a_Fibrillary_Matrix	Abnormal_Tissue_Present	Nests of Tumor Cell Nuclei in a Fibrillary Matrix
C41832	Convolution_Kernel	Algorithms	Convolution Kernel	An algorithm used to reconstruct imaging data.  Convolution kernels can be used to filter images to smooth them and reduce noise or to enhance edges or other image features.
C41833	Pineocyte	Retired_Concepts	Pineocyte
C41834	Pineal_Parenchyma	Neuroepithelial_Tissue	Pineal Parenchyma	The tissue of the pineal gland. The pineal gland is a small reddish-gray body, about 8 mm. in length which lies in the depression between the superior colliculi. It is attached to the roof of the third ventricle near its junction with the mid-brain. It develops as an outgrowth from the third ventricle of the brain. The pineal parenchyma consists of follicles lined by epithelium and enveloped by connective tissues. It produces and secretes melatonin.
C41835	Neoplastic_Small_Neuroepithelial_Cell	Neoplastic_Neuroepithelial_Cell	Neoplastic Small Neuroepithelial Cell
C41836	Neoplastic_Small_Immature_Neuroepithelial_Cell	Neoplastic_Small_Neuroepithelial_Cell	Neoplastic Small Immature Neuroepithelial Cell
C41837	Neoplastic_Small_Mature_Neuroepithelial_Cell	Neoplastic_Small_Neuroepithelial_Cell	Neoplastic Small Mature Neuroepithelial Cell
C41838	Large_Pineocytomatous_Rosette_Formation	Pineocytomatous_Rosette_Formation	Large Pineocytomatous Rosette Formation
C41839	Perivascular_Arrangement_of_Tumor_Cells	Morphologic_Architectural_Pattern	Perivascular Arrangement of Tumor Cells
C41840	Yp11_3	Chromosome_Band	Yp11.3	A chromosome band present on Yp
C41841	Clusters_and_Cords_of_GFAP_Positive_Epithelioid_Tumor_Cells_Present	Abnormal_Cells_Present	Clusters and Cords of GFAP Positive Epithelioid Tumor Cells Present
C41842	Gliomatosis_Cerebri_Type_I	Gliomatosis_Cerebri	Gliomatosis Cerebri Type I
C41843	Gliomatosis_Cerebri_Type_II	Gliomatosis_Cerebri	Gliomatosis Cerebri Type II
C41844	Regional_Disease	Clinical_Course_of_Disease	Regional Disease
C41845	_7_115428952-115480652	Chromosome_7_Physical_Location	7: 115428952-115480652	Physical location of CASP7_Gene
C41846	_2_201923719-201977938	Chromosome_2_Physical_Location	2: 201923719-201977938	Physical location of CASP8_Gene
C41847	_1_15596096-15564103	Chromosome_1_Physical_Location	1: 15596096-15564103	Physical location of CASP9_Gene
C41848	_7_115758790-115795181	Chromosome_7_Physical_Location	7: 115758790-115795181	Physical location of CAV1_Gene
C41849	_7_115733395-115742546	Chromosome_7_Physical_Location	7: 115733395-115742546	Physical location of CAV2_Gene
C41850	_8_93176619-93040326	Chromosome_8_Physical_Location	8: 93176619-93040326	Physical location of CBFA2T1_Gene
C41851	_16_65620551-65692462	Chromosome_16_Physical_Location	16: 65620551-65692462	Physical location of CBFB_Gene
C41852	_11_118582196-118675922	Chromosome_11_Physical_Location	11: 118582196-118675922	Physical location of CBL_Gene
C41853	_3_107070518-106859808	Chromosome_3_Physical_Location	3: 107070518-106859808	Physical location of CBLB_Gene
C41854	_3_42825980-42883779	Chromosome_3_Physical_Location	3: 42825980-42883779	Physical location of CCBP2_Gene
C41855	_11_6237542-6249932	Chromosome_11_Physical_Location	11: 6237542-6249932	Physical location of CCKBR_Gene
C41856	_17_29714365-29711512	Chromosome_17_Physical_Location	17: 29714365-29711512	Physical location of CCL1_Gene
C41857	_17_29636800-29639312	Chromosome_17_Physical_Location	17: 29636800-29639312	Physical location of CCL11_Gene
C41858	_17_29707584-29709742	Chromosome_17_Physical_Location	17: 29707584-29709742	Physical location of CCL13_Gene
C41859	_17_31337852-31334805	Chromosome_17_Physical_Location	17: 31337852-31334805	Physical location of CCL14_Gene
C41860	_17_31353125-31348777	Chromosome_17_Physical_Location	17: 31353125-31348777	Physical location of CCL15_Gene
C41861	_16_55996180-56007475	Chromosome_16_Physical_Location	16: 55996180-56007475	Physical location of CCL17_Gene
C41862	_17_31415756-31422954	Chromosome_17_Physical_Location	17: 31415756-31422954	Physical location of CCL18_Gene
C41863	_9_34681274-34679567	Chromosome_9_Physical_Location	9: 34681274-34679567	Physical location of CCL19_Gene
C41864	_17_29606411-29608335	Chromosome_17_Physical_Location	17: 29606411-29608335	Physical location of CCL2_Gene
C41865	_2_228504075-228507755	Chromosome_2_Physical_Location	2: 228504075-228507755	Physical location of CCL20_Gene
C41866	_9_34700147-34699002	Chromosome_9_Physical_Location	9: 34700147-34699002	Physical location of CCL21_Gene
C41867	_16_55950219-55957602	Chromosome_16_Physical_Location	16: 55950219-55957602	Physical location of CCL22_Gene
C41868	_17_31369118-31364210	Chromosome_17_Physical_Location	17: 31369118-31364210	Physical location of CCL23_Gene
C41869	_7_75087684-75085765	Chromosome_7_Physical_Location	7: 75087684-75085765	Physical location of CCL24_Gene
C41870	_19_8023934-8033547	Chromosome_19_Physical_Location	19: 8023934-8033547	Physical location of CCL25_Gene
C41871	_7_75046225-75043493	Chromosome_7_Physical_Location	7: 75046225-75043493	Physical location of CCL26_Gene
C41872	_9_34652689-34651894	Chromosome_9_Physical_Location	9: 34652689-34651894	Physical location of CCL27_Gene
C41873	_17_31441600-31439716	Chromosome_17_Physical_Location	17: 31441600-31439716	Physical location of CCL3_Gene
C41874	_17_31649843-31647955	Chromosome_17_Physical_Location	17: 31649843-31647955	Physical location of CCL3L1_Gene
C41875	_17_31455333-31457127	Chromosome_17_Physical_Location	17: 31455333-31457127	Physical location of CCL4_Gene
C41876	_17_31231490-31222611	Chromosome_17_Physical_Location	17: 31231490-31222611	Physical location of CCL5_Gene
C41877	_17_29621353-29623369	Chromosome_17_Physical_Location	17: 29621353-29623369	Physical location of CCL7_Gene
C41878	_17_29670179-29672534	Chromosome_17_Physical_Location	17: 29670179-29672534	Physical location of CCL8_Gene
C41879	_7_91520065-91472934	Chromosome_7_Physical_Location	7: 91520065-91472934	Physical location of CCM1_Gene
C41880	_4_123102497-123096130	Chromosome_4_Physical_Location	4: 123102497-123096130	Physical location of CCNA2_Gene
C41881	_5_68498669-68509826	Chromosome_5_Physical_Location	5: 68498669-68509826	Physical location of CCNB1_Gene
C41882	_15_57184612-57204536	Chromosome_15_Physical_Location	15: 57184612-57204536	Physical location of CCNB2_Gene
C41883	_11_69165054-69178423	Chromosome_11_Physical_Location	11: 69165054-69178423	Physical location of CCND1_Gene
C41884	_12_4253199-4284777	Chromosome_12_Physical_Location	12: 4253199-4284777	Physical location of CCND2_Gene
C41885	_19_34994741-35007059	Chromosome_19_Physical_Location	19: 34994741-35007059	Physical location of CCNE1_Gene
C41886	_8_95976660-95961628	Chromosome_8_Physical_Location	8: 95976660-95961628	Physical location of CCNE2_Gene
C41887	_3_46224820-46218720	Chromosome_3_Physical_Location	3: 46224820-46218720	Physical location of CCR1_Gene
C41888	_6_46386637-46392695	Chromosome_6_Physical_Location	6: 46386637-46392695	Physical location of CCR5_Gene
C41889	_6_167506668-167523040	Chromosome_6_Physical_Location	6: 167506668-167523040	Physical location of CCR6_Gene
C41890	_3_39346219-39351077	Chromosome_3_Physical_Location	3: 39346219-39351077	Physical location of CCR8_Gene
C41891	_3_45903023-45919671	Chromosome_3_Physical_Location	3: 45903023-45919671	Physical location of CCR9_Gene
C41892	_3_133798792-133804080	Chromosome_3_Physical_Location	3: 133798792-133804080	Physical location of CCRL1_Gene
C41893	_3_95821-98085	Chromosome_3_Physical_Location	3: 95821-98085	Physical location of CCRL2_Gene
C41894	_5_139992960-139991505	Chromosome_5_Physical_Location	5: 139992960-139991505	Physical location of CD14_Gene
C41895	_16_28850779-28858164	Chromosome_16_Physical_Location	16: 28850779-28858164	Physical location of CD19_Gene
C41896	_1_117009144-117023893	Chromosome_1_Physical_Location	1: 117009144-117023893	Physical location of CD2_Gene
C41897	_19_7718406-7710882	Chromosome_19_Physical_Location	19: 7718406-7710882	Physical location of CD209_Gene
C41898	_19_40511953-40530104	Chromosome_19_Physical_Location	19: 40511953-40530104	Physical location of CD22_Gene
C41899	_2_204396704-204428062	Chromosome_2_Physical_Location	2: 204396704-204428062	Physical location of CD28_Gene
C41900	_1_204472910-204448280	Chromosome_1_Physical_Location	1: 204472910-204448280	Physical location of CD34_Gene
C41901	_7_79920284-79948387	Chromosome_7_Physical_Location	7: 79920284-79948387	Physical location of CD36_Gene
C41902	_11_117718669-117714999	Chromosome_11_Physical_Location	11: 117718669-117714999	Physical location of CD3D_Gene
C41903	_11_117680824-117692096	Chromosome_11_Physical_Location	11: 117680824-117692096	Physical location of CD3E_Gene
C41904	_11_117720311-117729261	Chromosome_11_Physical_Location	11: 117720311-117729261	Physical location of CD3G_Gene
C41905	_1_164219484-164131543	Chromosome_1_Physical_Location	1: 164219484-164131543	Physical location of CD3Z_Gene
C41906	_12_6769005-6800235	Chromosome_12_Physical_Location	12: 6769005-6800235	Physical location of CD4_Gene
C41907	_11_35117306-35208150	Chromosome_11_Physical_Location	11: 35117306-35208150	Physical location of CD44_Gene
C41908	_3_109281882-109244836	Chromosome_3_Physical_Location	3: 109281882-109244836	Physical location of CD47_Gene
C41909	_1_26328627-26331156	Chromosome_1_Physical_Location	1: 26328627-26331156	Physical location of CD52_Gene
C41910	_1_116825645-116769199	Chromosome_1_Physical_Location	1: 116825645-116769199	Physical location of CD58_Gene
C41911	_17_77868741-77866035	Chromosome_17_Physical_Location	17: 77868741-77866035	Physical location of CD7_Gene
C41912	_9_35608408-35599976	Chromosome_9_Physical_Location	9: 35608408-35599976	Physical location of CD72_Gene
C41913	_3_120761139-120725832	Chromosome_3_Physical_Location	3: 120761139-120725832	Physical location of CD80_Gene
C41914	_2_87000696-86954120	Chromosome_2_Physical_Location	2: 87000696-86954120	Physical location of CD8B1_Gene
C41915	_19_14353266-14380535	Chromosome_19_Physical_Location	19: 14353266-14380535	Physical location of CD97_Gene
C41916	_10_62208242-62223930	Chromosome_10_Physical_Location	10: 62208242-62223930	Physical location of CDC2_Gene
C41917	_3_48204805-48173672	Chromosome_3_Physical_Location	3: 48204805-48173672	Physical location of CDC25A_Gene
C41918	_1_1686433-1666482	Chromosome_1_Physical_Location	1: 1686433-1666482	Physical location of CDC2L1_Gene
C41919	_19_10375271-10362809	Chromosome_19_Physical_Location	19: 10375271-10362809	Physical location of CDC37_Gene
C41920	_1_22124488-22164742	Chromosome_1_Physical_Location	1: 22124488-22164742	Physical location of CDC42_Gene
C41921	_22_17841970-17882689	Chromosome_22_Physical_Location	22: 17841970-17882689	Physical location of CDC45L_Gene
C41922	_17_35697672-35712539	Chromosome_17_Physical_Location	17: 35697672-35712539	Physical location of CDC6_Gene
C41923	_1_91678465-91703335	Chromosome_1_Physical_Location	1: 91678465-91703335	Physical location of CDC7_Gene
C41924	_20_3278550-32612008	Chromosome_20_Physical_Location	20: 3278550-32612008	Physical location of CDC91L1_Gene
C41925	_16_67328696-67426945	Chromosome_16_Physical_Location	16: 67328696-67426945	Physical location of CDH1_Gene
C41926	_16_81218079-82387702	Chromosome_16_Physical_Location	16: 81218079-82387702	Physical location of CDH13_Gene
C41927	_16_67236277-67290443	Chromosome_16_Physical_Location	16: 67236277-67290443	Physical location of CDH3_Gene
C41928	_16_64958064-64996190	Chromosome_16_Physical_Location	16: 64958064-64996190	Physical location of CDH5_Gene
C41929	_16_88280579-88290263	Chromosome_16_Physical_Location	16: 88280579-88290263	Physical location of CDK10_Gene
C41930	_12_54646826-54652835	Chromosome_12_Physical_Location	12: 54646826-54652835	Physical location of CDK2_Gene
C41931	_12_122281567-122270422	Chromosome_12_Physical_Location	12: 122281567-122270422	Physical location of CDK2AP1_Gene
C41932	_17_71509014-71513251	Chromosome_17_Physical_Location	17: 71509014-71513251	Physical location of CDK3_Gene
C41933	_12_56432431-56428270	Chromosome_12_Physical_Location	12: 56432431-56428270	Physical location of CDK4_Gene
C41934	_7_150192644-150188547	Chromosome_7_Physical_Location	7: 150192644-150188547	Physical location of CDK5_Gene
C41935	_4_76912750-76861526	Chromosome_4_Physical_Location	4: 76912750-76861526	Physical location of CDKL2_Gene
C41936	_6_36754465-36763087	Chromosome_6_Physical_Location	6: 36754465-36763087	Physical location of CDKN1A_Gene
C41937	_12_12761576-12766570	Chromosome_12_Physical_Location	12: 12761576-12766570	Physical location of CDKN1B_Gene
C41938	_11_2863551-2861452	Chromosome_11_Physical_Location	11: 2863551-2861452	Physical location of CDKN1C_Gene
C41939	_9_21984490-21957752	Chromosome_9_Physical_Location	9: 21984490-21957752	Physical location of CDKN2A_Gene
C41940	_9_21999312-21992903	Chromosome_9_Physical_Location	9: 21999312-21992903	Physical location of CDKN2B_Gene
C41941	_1_51146388-51152327	Chromosome_1_Physical_Location	1: 51146388-51152327	Physical location of CDKN2C_Gene
C41942	_14_53933476-53956682	Chromosome_14_Physical_Location	14: 53933476-53956682	Physical location of CDKN3_Gene
C41943	_11_125438397-125335784	Chromosome_11_Physical_Location	11: 125438397-125335784	Physical location of CDON_Gene
C41944	_X_139592243-139591945	Chromosome_X_Physical_Location	X: 139592243-139591945	Physical location of CDR1_Gene
C41945	_16_87397687-87413167	Chromosome_16_Physical_Location	16: 87397687-87413167	Physical location of CDT1_Gene
C41946	_13_27441317-27434279	Chromosome_13_Physical_Location	13: 27441317-27434279	Physical location of CDX2_Gene
C41947	_19_46914377-46925686	Chromosome_19_Physical_Location	19: 46914377-46925686	Physical location of CEACAM5_Gene
C41948	_19_46883936-46869075	Chromosome_19_Physical_Location	19: 46883936-46869075	Physical location of CEACAM7_Gene
C41949	_4_89735485-89784497	Chromosome_4_Physical_Location	4: 89735485-89784497	Physical location of CEB1_Gene
C41950	_19_38485160-38482776	Chromosome_19_Physical_Location	19: 38485160-38482776	Physical location of CEBPA_Gene
C41951	_14_22658314-22656355	Chromosome_14_Physical_Location	14: 22658314-22656355	Physical location of CEBPE_Gene
C41952	_22_45253586-45077250	Chromosome_22_Physical_Location	22: 45253586-45077250	Physical location of CELSR1_Gene
C41953	_1_211175452-211226309	Chromosome_1_Physical_Location	1: 211175452-211226309	Physical location of CENPF_Gene
C41954	_16_55553263-55575257	Chromosome_16_Physical_Location	16: 55553263-55575257	Physical location of CETP_Gene
C41955	_19_54219405-54217939	Chromosome_19_Physical_Location	19: 54219405-54217939	Physical location of CGB_Gene
C41956	_11_125001547-125030847	Chromosome_11_Physical_Location	11: 125001547-125030847	Physical location of CHEK1_Gene
C41957	_22_27465251-27408285	Chromosome_22_Physical_Location	22: 27465251-27408285	Physical location of CHEK2_Gene
C41958	_14_89155209-88697458	Chromosome_14_Physical_Location	14: 89155209-88697458	Physical location of CHES1_Gene
C41959	_14_92459245-92471389	Chromosome_14_Physical_Location	14: 92459245-92471389	Physical location of CHGA_Gene
C41960	_20_5840168-5854003	Chromosome_20_Physical_Location	20: 5840168-5854003	Physical location of CHGB_Gene
C41961	_11_67645434-67576904	Chromosome_11_Physical_Location	11: 67645434-67576904	Physical location of CHK_Gene
C41962	_11_62445588-62432728	Chromosome_11_Physical_Location	11: 62445588-62432728	Physical location of CHRM1_Gene
C41963	_1_236396793-236398565	Chromosome_1_Physical_Location	1: 236396793-236398565	Physical location of CHRM3_Gene
C41964	_11_46364683-46363244	Chromosome_11_Physical_Location	11: 46364683-46363244	Physical location of CHRM4_Gene
C41965	_15_32097720-32144579	Chromosome_15_Physical_Location	15: 32097720-32144579	Physical location of CHRM5_Gene
C41966	_1_232323008-232150384	Chromosome_1_Physical_Location	1: 232323008-232150384	Physical location of CHS1_Gene
C41967	_3_50624207-50618930	Chromosome_3_Physical_Location	3: 50624207-50618930	Physical location of CISH_Gene
C41968	_14_103058923-103055749	Chromosome_14_Physical_Location	14: 103058923-103055749	Physical location of CKB_Gene
C41969	_4_55365089-55447783	Chromosome_4_Physical_Location	4: 55365089-55447783	Physical location of C-KIT_Gene
C41970	_19_44920508-44913736	Chromosome_19_Physical_Location	19: 44920508-44913736	Physical location of CLC_Gene
C41971	_1_86601846-86633961	Chromosome_1_Physical_Location	1: 86601846-86633961	Physical location of CLCA2_Gene
C41972	_1_24817154-24916065	Chromosome_1_Physical_Location	1: 24817154-24916065	Physical location of CLIC4_Gene
C41973	_7_115906410-116032391	Chromosome_7_Physical_Location	7: 115906410-116032391	Physical location of C-MET_Gene
C41974	_12_107325559-107187814	Chromosome_12_Physical_Location	12: 107325559-107187814	Physical location of CMKLR1_Gene
C41975	_1_44935129-44940760	Chromosome_1_Physical_Location	1: 44935129-44940760	Physical location of CNK_Gene
C41976	_1_26188145-26200517	Chromosome_1_Physical_Location	1: 26188145-26200517	Physical location of CNK1_Gene
C41977	_17_68088158-38105358	Chromosome_17_Physical_Location	17: 68088158-38105358	Physical location of CNTNAP1_Gene
C41978	_21_45649525-45758062	Chromosome_21_Physical_Location	21: 45649525-45758062	Physical location of COL18A1_Gene
C41979	_17_45633992-45616456	Chromosome_17_Physical_Location	17: 45633992-45616456	Physical location of COL1A1_Gene
C41980	_7_93668858-93705195	Chromosome_7_Physical_Location	7: 93668858-93705195	Physical location of COL1A2_Gene
C41981	_2_227854786-228005012	Chromosome_2_Physical_Location	2: 227854786-228005012	Physical location of COL4A3_Gene
C41982	_X_10748856-107204991	Chromosome_X_Physical_Location	X: 10748856-107204991	Physical location of COL4A6_Gene
C41983	_22_18303863-18331084	Chromosome_22_Physical_Location	22: 18303863-18331084	Physical location of COMT_Gene
C41984	_8_100975071-100959548	Chromosome_8_Physical_Location	8: 100975071-100959548	Physical location of COX6C_Gene
C41985	_2_42500007-42489298	Chromosome_2_Physical_Location	2: 42500007-42489298	Physical location of COX7A2L_Gene
C41986	_16_88169677-88191155	Chromosome_16_Physical_Location	16: 88169677-88191155	Physical location of CPNE7_Gene
C41987	_2_208220192-208289079	Chromosome_2_Physical_Location	2: 208220192-208289079	Physical location of CREB1_Gene
C41988	_9_35722317-35727005	Chromosome_9_Physical_Location	9: 35722317-35727005	Physical location of CREB3_Gene
C41989	_7_28112180-18632857	Chromosome_7_Physical_Location	7: 28112180-18632857	Physical location of CREB5_Gene
C41990	_16_3870712-3716570	Chromosome_16_Physical_Location	16: 3870712-3716570	Physical location of CREBBP_Gene
C41991	_12_12656098-12689308	Chromosome_12_Physical_Location	12: 12656098-12689308	Physical location of CREBL2_Gene
C41992	_8_67253252-67251173	Chromosome_8_Physical_Location	8: 67253252-67251173	Physical location of CRH_Gene
C41993	_17_1306294-1272199	Chromosome_17_Physical_Location	17: 1306294-1272199	Physical location of CRK_Gene
C41994	_22_19596268-19632444	Chromosome_22_Physical_Location	22: 19596268-19632444	Physical location of CRKL_Gene
C41995	_X_40351037-40263812	Chromosome_X_Physical_Location	X: 40351037-40263812	Physical location of CRSP2_Gene
C41996	_6_131991056-131936801	Chromosome_6_Physical_Location	6: 131991056-131936801	Physical location of CRSP3_Gene
C41997	_11_93157096-93186102	Chromosome_11_Physical_Location	11: 93157096-93186102	Physical location of CRSP6_Gene
C41998	_19_16599754-16547838	Chromosome_19_Physical_Location	19: 16599754-16547838	Physical location of CRSP7_Gene
C41999	_9_131984807-131765053	Chromosome_9_Physical_Location	9: 131984807-131765053	Physical location of CRSP8_Gene
C42000	_5_156502453-156498017	Chromosome_5_Physical_Location	5: 156502453-156498017	Physical location of CRSP9_Gene
C42001	_2_131073278-131066531	Chromosome_2_Physical_Location	2: 131073278-131066531	Physical location of CRYPTIC_Gene
C42002	_1_110165499-110184397	Chromosome_1_Physical_Location	1: 110165499-110184397	Physical location of CSF1_Gene
C42003	_5_149473128-149413051	Chromosome_5_Physical_Location	5: 149473128-149413051	Physical location of CSF1R_Gene
C42004	_5_131437384-131439758	Chromosome_5_Physical_Location	5: 131437384-131439758	Physical location of CSF2_Gene
C42005	_X_9897925-9900718	Chromosome_X_Physical_Location	X: 9897925-9900718	Physical location of CSF2RA_Gene
C42006	_22_35642722-35659318	Chromosome_22_Physical_Location	22: 35642722-35659318	Physical location of CSF2RB_Gene
C42007	_17_35425214-35427592	Chromosome_17_Physical_Location	17: 35425214-35427592	Physical location of CSF3_Gene
C42008	_1_36617602-36600737	Chromosome_1_Physical_Location	1: 36617602-36600737	Physical location of CSF3R_Gene
C42009	_15_72861768-72882558	Chromosome_15_Physical_Location	15: 72861768-72882558	Physical location of CSK_Gene
C42010	_5_148910850-148855742	Chromosome_5_Physical_Location	5: 148910850-148855742	Physical location of CSNK1A1_Gene
C42011	_20_472482-411340	Chromosome_20_Physical_Location	20: 472482-411340	Physical location of CSNK2A1_Gene
C42012	_15_73792151-73754019	Chromosome_15_Physical_Location	15: 73792151-73754019	Physical location of CSPG4_Gene
C42013	_10_112317474-112354382	Chromosome_10_Physical_Location	10: 112317474-112354382	Physical location of CSPG6_Gene
C42014	_11_65536038-65537552	Chromosome_11_Physical_Location	11: 65536038-65537552	Physical location of CST6_Gene
C42015	_4_1232621-1195118	Chromosome_4_Physical_Location	4: 1232621-1195118	Physical location of CTBP1_Gene
C42016	_10_126839019-126667391	Chromosome_10_Physical_Location	10: 126839019-126667391	Physical location of CTBP2_Gene
C42017	_16_30815429-30822382	Chromosome_16_Physical_Location	16: 30815429-30822382	Physical location of CTF1_Gene
C42018	_2_204558017-204564189	Chromosome_2_Physical_Location	2: 204558017-204564189	Physical location of CTLA4_Gene
C42019	_3_41216004-41256938	Chromosome_3_Physical_Location	3: 41216004-41256938	Physical location of CTNNB1_Gene
C42020	_8_11763044-11739236	Chromosome_8_Physical_Location	8: 11763044-11739236	Physical location of CTSB_Gene
C42021	_11_1741798-1730561	Chromosome_11_Physical_Location	11: 1741798-1730561	Physical location of CTSD_Gene
C42022	_15_77024475-77001162	Chromosome_15_Physical_Location	15: 77024475-77001162	Physical location of CTSH_Gene
C42023	_9_87570534-87575862	Chromosome_9_Physical_Location	9: 87570534-87575862	Physical location of CTSL_Gene
C42024	_20_57015697-57003635	Chromosome_20_Physical_Location	20: 57015697-57003635	Physical location of CTSZ_Gene
C42025	_7_147833581-147935850	Chromosome_7_Physical_Location	7: 147833581-147935850	Physical location of CUL1_Gene
C42026	_10_35419300-35338814	Chromosome_10_Physical_Location	10: 35419300-35338814	Physical location of CUL2_Gene
C42027	_2_225275619-225160374	Chromosome_2_Physical_Location	2: 225275619-225160374	Physical location of CUL3_Gene
C42028	_13_112912288-112967400	Chromosome_13_Physical_Location	13: 112912288-112967400	Physical location of CUL4A_Gene
C42029	_11_107384855-107482789	Chromosome_11_Physical_Location	11: 107384855-107482789	Physical location of CUL5_Gene
C42030	_16_55963900-55976457	Chromosome_16_Physical_Location	16: 55963900-55976457	Physical location of CX3CL1_Gene
C42031	_3_39296526-39279991	Chromosome_3_Physical_Location	3: 39296526-39279991	Physical location of CX3CR1_Gene
C42032	_4_75100144-75101988	Chromosome_4_Physical_Location	4: 75100144-75101988	Physical location of CXCL1_Gene
C42033	_4_77301829-77299452	Chromosome_4_Physical_Location	4: 77301829-77299452	Physical location of CXCL10_Gene
C42034	_4_77314415-77312021	Chromosome_4_Physical_Location	4: 77314415-77312021	Physical location of CXCL11_Gene
C42035	_10_44200551-44185613	Chromosome_10_Physical_Location	10: 44200551-44185613	Physical location of CXCL12_Gene
C42036	_4_78884157-78890165	Chromosome_4_Physical_Location	4: 78884157-78890165	Physical location of CXCL13_Gene
C42037	_5_134942868-134934274	Chromosome_5_Physical_Location	5: 134942868-134934274	Physical location of CXCL14_Gene
C42038	_4_75329947-75327791	Chromosome_4_Physical_Location	4: 75329947-75327791	Physical location of CXCL2_Gene
C42039	_4_75269440-75267349	Chromosome_4_Physical_Location	4: 75269440-75267349	Physical location of CXCL3_Gene
C42040	_4_75229451-775226395	Chromosome_4_Physical_Location	4: 75229451-775226395	Physical location of CXCL5_Gene
C42041	_4_75067448-75069512	Chromosome_4_Physical_Location	4: 75067448-75069512	Physical location of CXCL6_Gene
C42042	_4_77285820-77279802	Chromosome_4_Physical_Location	4: 77285820-77279802	Physical location of CXCL9_Gene
C42043	_X_70621388-70618788	Chromosome_X_Physical_Location	X: 70621388-70618788	Physical location of CXCR3_Gene
C42044	_2_136709450-136705639	Chromosome_2_Physical_Location	2: 136709450-136705639	Physical location of CXCR4_Gene
C42045	_3_45959977-45964849	Chromosome_3_Physical_Location	3: 45959977-45964849	Physical location of CXCR6_Gene
C42046	Undifferentiated_Neuroblastoma	Neuroblastoma	Undifferentiated Neuroblastoma
C42047	Poorly_Differentiated_Neuroblastoma	Neuroblastoma	Poorly Differentiated Neuroblastoma
C42048	Differentiating_Neuroblastoma	Neuroblastoma	Differentiating Neuroblastoma
C42049	Prominent_Schwannian_Stroma_Present	Stromal_Change	Prominent Schwannian Stroma Present
C42050	Neuroectodermal_Cell	Ectoderm_Cell|Neuroepithelial_Cell	Neuroectodermal Cell	An embryonic cell on the dorsal surface of the early vertebrate embryo that gives rise to the cells of the nervous system
C42051	Neuropil_Present	Morphologic_Finding	Neuropil Present
C42052	Differentiating_Neuroblasts_Under_5_Percent	Differentiating_Neuroblasts_Present	Differentiating Neuroblasts Under 5 Percent of the Tumor Cells
C42053	Differentiating_Neuroblasts_More_than_5_Percent_of_the_Tumor_Cells	Differentiating_Neuroblasts_Present	Differentiating Neuroblasts More than 5 Percent of the Tumor Cells
C42054	Differentiating_Neuroblasts_Present	Abnormal_Cells_Present	Differentiating Neuroblasts Present
C42055	Monoclonal_Antibody_Bombesin-DTPA	Monoclonal_Antibody	Monoclonal Antibody Bombesin-DTPA|MOAB BOMBESIN (DTPA)	A monoclonal antibody directed against the neurohormone bombesin that is conjugated to diethylenetriaminepenta-acetic acid (DPTA), a bifunctional chelating agent that allows the antibody to be labeled with a metal species such as radioactive indium.  Levels of bombesin, also known as gastrin releasing peptide (GRP), are elevated in lung and thyroid cancers, where the substance acts as an autocrine growth factor. (NCI04)
C42056	Monoclonal_Antibody_Bombesin-ITC-D	Monoclonal_Antibody	Monoclonal Antibody Bombesin-ITC-D|MOAB BOMBESIN (ITC-D)	A monoclonal antibody directed against the neurohormone bombesin that is conjugated to isothiocyanobenzyl diethylenetriaminepentaacetic acid (ITC-D), a bifunctional chelating agent that allows the antibody to be labeled with a metal species. Levels of the neurohormone bombesin, also known as gastrin releasing peptide (GRP), are elevated in lung and thyroid cancers, where the substance acts as an autocrine growth factor. (NCI04)
C42057	Ganglioneuroblastoma_Intermixed	Ganglioneuroblastoma	Ganglioneuroblastoma, Intermixed|Ganglioneuroblastoma, Intermixed (Schwannian Stroma-Rich)
C42058	Ganglioneuroblastoma_Nodular	Ganglioneuroblastoma	Ganglioneuroblastoma, Nodular
C42059	Composite_Ganglioneuroblastoma_Schwannian_Stroma_Rich_and_Stroma_Poor	Ganglioneuroblastoma_Nodular	Composite Ganglioneuroblastoma, Schwannian Stroma-Rich and Stroma-Poor
C42060	Composite_Ganglioneuroblastoma_Stroma_Dominant_and_Stroma_Poor	Ganglioneuroblastoma_Nodular	Composite Ganglioneuroblastoma, Stroma-Dominant and Stroma-Poor
C42062	Schwannian_Stroma_More_than_50_Percent_of_the_Tumor_Volume	Prominent_Schwannian_Stroma_Present	Schwannian Stroma More than 50 Percent of the Tumor Volume
C42063	Schwannian_Stroma_Predominant_Component_of_the_Tumor_Volume	Schwannian_Stroma_More_than_50_Percent_of_the_Tumor_Volume	Schwannian Stroma Predominant Component of the Tumor Volume
C42064	Maturing_Ganglioneuroma	Ganglioneuroma	Maturing Ganglioneuroma
C42065	Mature_Ganglioneuroma	Ganglioneuroma	Mature Ganglioneuroma
C42066	Hemorrhagic_Neuroblastic_Nodules_Present	Morphologic_Finding	Hemorrhagic Neuroblastic Nodules Present|Stroma-Poor Component Present
C42067	Ganglioneuroblastoma_Component_Present	Abnormal_Tissue_Present	Ganglioneuroblastoma Component Present
C42068	Ganglioneuroma_Component_Present	Abnormal_Tissue_Present	Ganglioneuroma Component Present
C42069	Maturing_Ganglion_Cells_Present	Abnormal_Cells_Present|Ganglion_Cells_Present	Maturing Ganglion Cells Present
C42070	Mature_Ganglion_Cells_Present	Ganglion_Cells_Present	Mature Ganglion Cells Present
C42071	Mature_Schwannian_Stroma_Present	Abnormal_Tissue_Present	Mature Schwannian Stroma Present
C42072	Ganglion_Cells_Present	Morphologic_Finding	Ganglion Cells Present
C42074	Scattered_Collections_of_Differentiating_Neuroblasts_Present	Abnormal_Cells_Present	Scattered Collections of Differentiating Neuroblasts Present
C42075	Abnormal_Tissue_Present	Morphologic_Finding	Abnormal Tissue Present
C42076	Abnormal_Cells_Present	Morphologic_Finding	Abnormal Cells Present
C42077	Cellular_Infiltrate	Morphologic_Finding	Cellular Infiltrate
C42078	Lesion_by_Morphology	Lesion|Morphologic_Finding	Lesion by Morphology
C42079	Choroid_Plexus_Epithelium	Epithelium	Choroid Plexus Epithelium
C42080	Childhood_Choroid_Plexus_Neoplasm	Choroid_Plexus_Neoplasm	Childhood Choroid Plexus Neoplasm
C42081	Cauliflower_like_Mass	Mass	Cauliflower-Like Mass
C42082	Neoplastic_Cuboidal_Cell	Neoplastic_Epithelial_Cell	Neoplastic Cuboidal Cell
C42083	Neuronal_Differentiation	Tissue_Differentiation	Neuronal Differentiation
C42084	Neoplastic_Mature_Ganglion_Cell	Neoplastic_Ganglion_Cell	Neoplastic Mature Ganglion Cell
C42085	Dysplastic_Ganglion_Cell	Neoplastic_Ganglion_Cell	Dysplastic Ganglion Cell
C42086	Downward_Ocular_Deviation	Eye_and_Ear_Finding	Downward Ocular Deviation|Sunset Sign
C42087	Aggregates_of_Poorly_Differentiated_Neuroepithelial_Cells_Present	Morphologic_Finding	Aggregates of Poorly Differentiated Neuroepithelial Cells Present
C42088	Cortical_Dysplasia	Dysplasia	Cortical Dysplasia
C42089	Pale_Eosinophilic_Stroma_Formation	Stromal_Change	Pale Eosinophilic Stroma Formation
C42091	Lipomatous_Differentiation	Mesenchymal_Differentiation	Lipomatous Differentiation
C42092	Neoplastic_Round_Neuroepithelial_Cell	Neoplastic_Neuroepithelial_Cell	Neoplastic Round Neuroepithelial Cell
C42093	Neoplastic_Maturing_Ganglion_Cell	Neoplastic_Ganglion_Cell	Neoplastic Maturing Ganglion Cell
C42094	Rare_Lesion	Lesion	Rare Lesion
C42095	Tissue_Differentiation	Morphologic_Finding	Tissue Differentiation
C42096	_15_72447020-72417157	Chromosome_15_Physical_Location	15: 72447020-72417157	Physical location of CYP11A1_Gene
C42097	_8_143958238-143952218	Chromosome_8_Physical_Location	8: 143958238-143952218	Physical location of CYP11B1_Gene
C42098	_8_143996261-143988977	Chromosome_8_Physical_Location	8: 143996261-143988977	Physical location of CYP11B2_Gene
C42099	_10_104587168-104580284	Chromosome_10_Physical_Location	10: 104587168-104580284	Physical location of CYP17A1_Gene
C42100	_15_49403413-49288961	Chromosome_15_Physical_Location	15: 49403413-49288961	Physical location of CYP19A1_Gene
C42101	_15_72804930-72798943	Chromosome_15_Physical_Location	15: 72804930-72798943	Physical location of CYP1A1_Gene
C42102	_15_72828237-72835994	Chromosome_15_Physical_Location	15: 72828237-72835994	Physical location of CYP1A2_Gene
C42103	_6_32114061-32117396	Chromosome_6_Physical_Location	6: 32114061-32117396	Physical location of CYP21A2_Gene
C42104	_12_56447151-56442386	Chromosome_12_Physical_Location	12: 56447151-56442386	Physical location of CYP27B1_Gene
C42105	_19_46189044-46216141	Chromosome_19_Physical_Location	19: 46189044-46216141	Physical location of CYP2B6_Gene
C42106	_10_9643368-96485514	Chromosome_10_Physical_Location	10: 9643368-96485514	Physical location of CYP2C18_Gene
C42107	_10_96512453-96602661	Chromosome_10_Physical_Location	10: 96512453-96602661	Physical location of CYP2C19_Gene
C42108	_10_96688430-96739137	Chromosome_10_Physical_Location	10: 96688430-96739137	Physical location of CYP2C9_Gene
C42109	_22_40851379-40847001	Chromosome_22_Physical_Location	22: 40851379-40847001	Physical location of CYP2D6_Gene
C42110	_10_135229746-135241501	Chromosome_10_Physical_Location	10: 135229746-135241501	Physical location of CYP2E1_Gene
C42111	_7_99026459-98999255	Chromosome_7_Physical_Location	7: 99026459-98999255	Physical location of CYP3A4_Gene
C42112	_8_59575275-59565292	Chromosome_8_Physical_Location	8: 59575275-59565292	Physical location of CYP7A1_Gene
C42113	_3_42892637-42888688	Chromosome_3_Physical_Location	3: 42892637-42888688	Physical location of CYP8B1_Gene
C42114	_10_61336314-61218528	Chromosome_10_Physical_Location	10: 61336314-61218528	Physical location of D10S170
C42115	_5_39430280-39408488	Chromosome_5_Physical_Location	5: 39430280-39408488	Physical location of DAB2_Gene
C42116	_6_33398676-33394367	Chromosome_6_Physical_Location	6: 33398676-33394367	Physical location of DAXX_Gene
C42117	_9_119211255-119008462	Chromosome_9_Physical_Location	9: 119211255-119008462	Physical location of DBCCR1_Gene
C42118	_18_48121156-49311286	Chromosome_18_Physical_Location	18: 48121156-49311286	Physical location of DCC_Gene
C42119	_4_72224427-72261648	Chromosome_4_Physical_Location	4: 72224427-72261648	Physical location of DCK_Gene
C42120	_6_30959840-30975912	Chromosome_6_Physical_Location	6: 30959840-30975912	Physical location of DDR1_Gene
C42121	_1_159333918-159481869	Chromosome_1_Physical_Location	1: 159333918-159481869	Physical location of DDR2_Gene
C42122	_2_15682368-15721823	Chromosome_2_Physical_Location	2: 15682368-15721823	Physical location of DDX1_Gene
C42123	_6_30748736-30728886	Chromosome_6_Physical_Location	6: 30748736-30728886	Physical location of DDX16_Gene
C42124	_13_50925135-50837364	Chromosome_13_Physical_Location	13: 50925135-50837364	Physical location of DDX26_Gene
C42125	_11_118167082-118125623	Chromosome_11_Physical_Location	11: 118167082-118125623	Physical location of DDX6_Gene
C42126	_9_114983651-115244477	Chromosome_9_Physical_Location	9: 114983651-115244477	Physical location of DEC1_Gene
C42127	_8_6722860-6715525	Chromosome_8_Physical_Location	8: 6722860-6715525	Physical location of DEFB1_Gene
C42128	_6_18372750-18332392	Chromosome_6_Physical_Location	6: 18372750-18332392	Physical location of DEK_Gene
C42129	_5_79986572-79957804	Chromosome_5_Physical_Location	5: 79986572-79957804	Physical location of DHFR_Gene
C42130	_16_70600164-70616456	Chromosome_16_Physical_Location	16: 70600164-70616456	Physical location of DHODH_Gene
C42131	_19_12653677-12647534	Chromosome_19_Physical_Location	19: 12653677-12647534	Physical location of DHPS_Gene
C42132	_14_94693512-94622319	Chromosome_14_Physical_Location	14: 94693512-94622319	Physical location of DICER1_Gene
C42133	_8_13416766-12985243	Chromosome_8_Physical_Location	8: 13416766-12985243	Physical location of DLC1_Gene
C42134	_3_38055700-38139233	Chromosome_3_Physical_Location	3: 38055700-38139233	Physical location of DLEC1_Gene
C42135	_13_49554308-49577434	Chromosome_13_Physical_Location	13: 49554308-49577434	Physical location of DLEU1_Gene
C42136	_13_49554115-49515574	Chromosome_13_Physical_Location	13: 49554115-49515574	Physical location of DLEU2_Gene
C42137	_3_198513757-198259733	Chromosome_3_Physical_Location	3: 198513757-198259733	Physical location of DLG1_Gene
C42138	_17_7063754-7033933	Chromosome_17_Physical_Location	17: 7063754-7033933	Physical location of DLG4_Gene
C42139	_10_124310171-124393242	Chromosome_10_Physical_Location	10: 124310171-124393242	Physical location of DMBT1_Gene
C42140	_20_30813852-30860823	Chromosome_20_Physical_Location	20: 30813852-30860823	Physical location of DNMT3B_Gene
C42141	_10_98054202-98088311	Chromosome_10_Physical_Location	10: 98054202-98088311	Physical location of DNTT_Gene
C42142	_11_67032678-67030545	Chromosome_11_Physical_Location	11: 67032678-67030545	Physical location of DOC-1R_Gene
C42143	_10_128658955-129140571	Chromosome_10_Physical_Location	10: 128658955-129140571	Physical location of DOCK1_Gene
C42144	_2_74693515-74696318	Chromosome_2_Physical_Location	2: 74693515-74696318	Physical location of DOK1_Gene
C42145	_1_98098600-97255323	Chromosome_1_Physical_Location	1: 98098600-97255323	Physical location of DPYD_Gene
C42146	_1_93523499-93540170	Chromosome_1_Physical_Location	1: 93523499-93540170	Physical location of DR1_Gene
C42147	_11_65443304-65445607	Chromosome_11_Physical_Location	11: 65443304-65445607	Physical location of DRAP1_Gene
C42148	_5_174803769-1748006433	Chromosome_5_Physical_Location	5: 174803769-1748006433	Physical location of DRD1_Gene
C42149	_11_112851091-112785527	Chromosome_11_Physical_Location	11: 112851091-112785527	Physical location of DRD2_Gene
C42150	_11_627305-630703	Chromosome_11_Physical_Location	11: 627305-630703	Physical location of DRD4_Gene
C42151	_4_9459872-9461902	Chromosome_4_Physical_Location	4: 9459872-9461902	Physical location of DRD5_Gene
C42152	_5_139706358-139692613	Chromosome_5_Physical_Location	5: 139706358-139692613	Physical location of DTR_Gene
C42153	_12_11958382-111998553	Chromosome_12_Physical_Location	12: 11958382-111998553	Physical location of DTX1_Gene
C42154	_5_172130809-172127707	Chromosome_5_Physical_Location	5: 172130809-172127707	Physical location of DUSP1_Gene
C42155	_17_39211872-39199016	Chromosome_17_Physical_Location	17: 39211872-39199016	Physical location of DUSP3_Gene
C42156	_20_31737854-31727150	Chromosome_20_Physical_Location	20: 31737854-31727150	Physical location of E2F1_Gene
C42157	_1_222435655-222431039	Chromosome_1_Physical_Location	1: 222435655-222431039	Physical location of EBAF_Gene
C42158	_22_49258599-49254325	Chromosome_22_Physical_Location	22: 49258599-49254325	Physical location of ECGF1_Gene
C42159	_6_12398645-12404771	Chromosome_6_Physical_Location	6: 12398645-12404771	Physical location of EDN1_Gene
C42160	_1_41619390-41613540	Chromosome_1_Physical_Location	1: 41619390-41613540	Physical location of EDN2_Gene
C42161	_6_74287475-74283962	Chromosome_6_Physical_Location	6: 74287475-74283962	Physical location of EEF1A1_Gene
C42162	_20_61600949-61589810	Chromosome_20_Physical_Location	20: 61600949-61589810	Physical location of EEF1A2_Gene
C42163	_15_50584606-50585400	Chromosome_15_Physical_Location	15: 50584606-50585400	Physical location of EEF1B1_Gene
C42164	_2_206849840-206853158	Chromosome_2_Physical_Location	2: 206849840-206853158	Physical location of EEF1B2_Gene
C42165	_8_144750726-144733041	Chromosome_8_Physical_Location	8: 144750726-144733041	Physical location of EEF1D_Gene
C42166	_11_62097927-62083649	Chromosome_11_Physical_Location	11: 62097927-62083649	Physical location of EEF1G_Gene
C42167	_19_3936446-3927055	Chromosome_19_Physical_Location	19: 3936446-3927055	Physical location of EEF2_Gene
C42168	_4_111191654-111291023	Chromosome_4_Physical_Location	4: 111191654-111291023	Physical location of EGF_Gene
C42169	_X_13347398-13411351	Chromosome_X_Physical_Location	X: 13347398-13411351	Physical location of EGFL6_Gene
C42170	_7_54860934-55049240	Chromosome_7_Physical_Location	7: 54860934-55049240	Physical location of EGFR_Gene
C42171	_11_34599244-34639357	Chromosome_11_Physical_Location	11: 34599244-34639357	Physical location of EHF_Gene
C42172	_12_122642993-122630453	Chromosome_12_Physical_Location	12: 122642993-122630453	Physical location of EIF2B1_Gene
C42173	_14_74539401-74546045	Chromosome_14_Physical_Location	14: 74539401-74546045	Physical location of EIF2B2_Gene
C42174	_2_27504851-27498881	Chromosome_2_Physical_Location	2: 27504851-27498881	Physical location of EIF2B4_Gene
C42175	_3_185335826-185345798	Chromosome_3_Physical_Location	3: 185335826-185345798	Physical location of EIF2B5_Gene
C42176	_8_109330128-109283148	Chromosome_8_Physical_Location	8: 109330128-109283148	Physical location of EIF3S6_Gene
C42177	_2_233240926-233259424	Chromosome_2_Physical_Location	2: 233240926-233259424	Physical location of EIF4EL3_Gene
C42178	_1_198708730-198716790	Chromosome_1_Physical_Location	1: 198708730-198716790	Physical location of ELF3_Gene
C42179	_X_47266274-47251174	Chromosome_X_Physical_Location	X: 47266274-47251174	Physical location of ELK1_Gene
C42180	_12_95090785-95064077	Chromosome_12_Physical_Location	12: 95090785-95064077	Physical location of ELK3_Gene
C42181	_2_27213585-27220914	Chromosome_2_Physical_Location	2: 27213585-27220914	Physical location of EMILIN_Gene
C42182	_12_13240924-13260975	Chromosome_12_Physical_Location	12: 13240924-13260975	Physical location of EMP1_Gene
C42183	_11_69922292-69960338	Chromosome_11_Physical_Location	11: 69922292-69960338	Physical location of EMS1_Gene
C42184	_9_12769538-127656850	Chromosome_9_Physical_Location	9: 12769538-127656850	Physical location of ENG_Gene
C42185	_22_39812290-39900045	Chromosome_22_Physical_Location	22: 39812290-39900045	Physical location of EP300_Gene
C42186	_7_142622822-142605042	Chromosome_7_Physical_Location	7: 142622822-142605042	Physical location of EPHA1_Gene
C42187	_1_16228780-16196139	Chromosome_1_Physical_Location	1: 16228780-16196139	Physical location of EPHA2_Gene
C42188	_3_89239364-89613974	Chromosome_3_Physical_Location	3: 89239364-89613974	Physical location of EPHA3_Gene
C42189	_2_222262515-222108254	Chromosome_2_Physical_Location	2: 222262515-222108254	Physical location of EPHA4_Gene
C42190	_1_22635323-22675393	Chromosome_1_Physical_Location	1: 22635323-22675393	Physical location of EPHA8_Gene
C42191	_3_135996958-136461353	Chromosome_3_Physical_Location	3: 135996958-136461353	Physical location of EPHB1_Gene
C42192	_1_22782764-22987098	Chromosome_1_Physical_Location	1: 22782764-22987098	Physical location of EPHB2_Gene
C42193	_3_185762289-185782898	Chromosome_3_Physical_Location	3: 185762289-185782898	Physical location of EPHB3_Gene
C42194	_1_222319711-222339996	Chromosome_1_Physical_Location	1: 222319711-222339996	Physical location of EPHX1_Gene
C42195	_7_99963074-99965974	Chromosome_7_Physical_Location	7: 99963074-99965974	Physical location of EPO_Gene
C42196	_19_11356019-11349475	Chromosome_19_Physical_Location	19: 11356019-11349475	Physical location of EPOR_Gene
C42197	_1_51697016-51532920	Chromosome_1_Physical_Location	1: 51697016-51532920	Physical location of EPS15_Gene
C42198	_12_15833589-15664365	Chromosome_12_Physical_Location	12: 15833589-15664365	Physical location of EPS8_Gene
C42199	_19_60275200-60291103	Chromosome_19_Physical_Location	19: 60275200-60291103	Physical location of EPS8L1_Gene
C42200	_11_696120-717727	Chromosome_11_Physical_Location	11: 696120-717727	Physical location of EPS8L2_Gene
C42201	_1_110018606-110004744	Chromosome_1_Physical_Location	1: 110018606-110004744	Physical location of EPS8L3_Gene
C42202	_13_42464366-42360123	Chromosome_13_Physical_Location	13: 42464366-42360123	Physical location of EPSTI1_Gene
C42203	_17_35109922-35138436	Chromosome_17_Physical_Location	17: 35109922-35138436	Physical location of ERBB2_Gene
C42204	_5_65258140-65412100	Chromosome_5_Physical_Location	5: 65258140-65412100	Physical location of ERBB2IP_Gene
C42205	_12_54760154-54782854	Chromosome_12_Physical_Location	12: 54760154-54782854	Physical location of ERBB3_Gene
C42206	_2_213228793-212072321	Chromosome_2_Physical_Location	2: 213228793-212072321	Physical location of ERBB4_Gene
C42207	_19_50619017-50604712	Chromosome_19_Physical_Location	19: 50619017-50604712	Physical location of ERCC1_Gene
C42208	_19_50565669-50546686	Chromosome_19_Physical_Location	19: 50565669-50546686	Physical location of ERCC2_Gene
C42209	_2_127767982-127731096	Chromosome_2_Physical_Location	2: 127767982-127731096	Physical location of ERCC3_Gene
C42210	_16_13921524-13949705	Chromosome_16_Physical_Location	16: 13921524-13949705	Physical location of ERCC4_Gene
C42211	_13_102296421-102326346	Chromosome_13_Physical_Location	13: 102296421-102326346	Physical location of ERCC5_Gene
C42212	_10_50417078-50336715	Chromosome_10_Physical_Location	10: 50417078-50336715	Physical location of ERCC6_Gene
C42213	_4_75595895-75619512	Chromosome_4_Physical_Location	4: 75595895-75619512	Physical location of EREG_Gene
C42214	_19_48451113-47443542	Chromosome_19_Physical_Location	19: 48451113-47443542	Physical location of ERF_Gene
C42215	_21_38878739-38675671	Chromosome_21_Physical_Location	21: 38878739-38675671	Physical location of ERG_Gene
C42216	_6_152220800-152516520	Chromosome_6_Physical_Location	6: 152220800-152516520	Physical location of ESR1_Gene
C42217	_14_63830831-63769608	Chromosome_14_Physical_Location	14: 63830831-63769608	Physical location of ESR2_Gene
C42218	_11_127897371-127833873	Chromosome_11_Physical_Location	11: 127897371-127833873	Physical location of ETS1_Gene
C42219	_21_39099719-39118749	Chromosome_21_Physical_Location	21: 39099719-39118749	Physical location of ETS2_Gene
C42220	_7_13803555-13708330	Chromosome_7_Physical_Location	7: 13803555-13708330	Physical location of ETV1_Gene
C42221	_1_153921250-153916049	Chromosome_1_Physical_Location	1: 153921250-153916049	Physical location of ETV3_Gene
C42222	_17_38978773-38960740	Chromosome_17_Physical_Location	17: 38978773-38960740	Physical location of ETV4_Gene
C42223	_12_11694055-11939603	Chromosome_12_Physical_Location	12: 11694055-11939603	Physical location of ETV6_Gene
C42224	_3_170346795-170285252	Chromosome_3_Physical_Location	3: 170346795-170285252	Physical location of EVI1_Gene
C42225	_17_26665217-26654919	Chromosome_17_Physical_Location	17: 26665217-26654919	Physical location of EVI2B_Gene
C42226	_22_27988825-28021059	Chromosome_22_Physical_Location	22: 27988825-28021059	Physical location of EWSR1_Gene
C42227	_1_238337576-238379089	Chromosome_1_Physical_Location	1: 238337576-238379089	Physical location of EXO1_Gene
C42228	_8_119193239-118880787	Chromosome_8_Physical_Location	8: 119193239-118880787	Physical location of EXT1_Gene
C42229	_11_44073675-44223556	Chromosome_11_Physical_Location	11: 44073675-44223556	Physical location of EXT2_Gene
C42230	_1_26032413-26047074	Chromosome_1_Physical_Location	1: 26032413-26047074	Physical location of EXTL1_Gene
C42231	_1_101072389-101049965	Chromosome_1_Physical_Location	1: 101072389-101049965	Physical location of EXTL2_Gene
C42232	_8_28626893-28667121	Chromosome_8_Physical_Location	8: 28626893-28667121	Physical location of EXTL3_Gene
C42233	_7_148019062-147942123	Chromosome_7_Physical_Location	7: 148019062-147942123	Physical location of EZH2_Gene
C42234	_5_76047542-76067054	Chromosome_5_Physical_Location	5: 76047542-76067054	Physical location of F2R_Gene
C42235	_1_94719336-94706894	Chromosome_1_Physical_Location	1: 94719336-94706894	Physical location of F3_Gene
C42236	_13_112808106-112822346	Chromosome_13_Physical_Location	13: 112808106-112822346	Physical location of F7_Gene
C42237	_X_154175290-153627773	Chromosome_X_Physical_Location	X: 154175290-153627773	Physical location of F8_Gene
C42238	_X_138228415-138371137	Chromosome_X_Physical_Location	X: 138228415-138371137	Physical location of F9_Gene
C42239	_2_88266840-88261772	Chromosome_2_Physical_Location	2: 88266840-88261772	Physical location of FABP1_Gene
C42240	_4_120600921-120596009	Chromosome_4_Physical_Location	4: 120600921-120596009	Physical location of FABP2_Gene
C42241	_1_31514981-31507594	Chromosome_1_Physical_Location	1: 31514981-31507594	Physical location of FABP3_Gene
C42242	_8_82552004-82553481	Chromosome_8_Physical_Location	8: 82552004-82553481	Physical location of FABP4_Gene
C42243	_8_82355340-82359563	Chromosome_8_Physical_Location	8: 82355340-82359563	Physical location of FABP5_Gene
C42244	_11_69726917-69731144	Chromosome_11_Physical_Location	11: 69726917-69731144	Physical location of FADD_Gene
C42245	_9_35070013-35063835	Chromosome_9_Physical_Location	9: 35070013-35063835	Physical location of FANCG_Gene
C42246	_2_162925552-162852709	Chromosome_2_Physical_Location	2: 162925552-162852709	Physical location of FAP_Gene
C42247	_17_77649395-77629503	Chromosome_17_Physical_Location	17: 77649395-77629503	Physical location of FASN_Gene
C42248	_7_150215599-150211356	Chromosome_7_Physical_Location	7: 150215599-150211356	Physical location of FASTK_Gene
C42249	_4_188020126-187884098	Chromosome_4_Physical_Location	4: 188020126-187884098	Physical location of FAT_Gene
C42250	_4_153690635-153601100	Chromosome_4_Physical_Location	4: 153690635-153601100	Physical location of FBXW7_Gene
C42251	_1_158288316-158302322	Chromosome_1_Physical_Location	1: 158288316-158302322	Physical location of FCGR2A_Gene
C42252	_1_158364622-158379489	Chromosome_1_Physical_Location	1: 158364622-158379489	Physical location of FCGR2B_Gene
C42253	_1_158364633-158379375	Chromosome_1_Physical_Location	1: 158364633-158379375	Physical location of FCGR2C_Gene
C42254	_1_158332873-158324608	Chromosome_1_Physical_Location	1: 158332873-158324608	Physical location of FCGR3A_Gene
C42255	_1_158332614-158325768	Chromosome_1_Physical_Location	1: 158332614-158325768	Physical location of FCGR3B_Gene
C42256	_5_108111422-108551272	Chromosome_5_Physical_Location	5: 108111422-108551272	Physical location of FER_Gene
C42257	_5_142045812-141953308	Chromosome_5_Physical_Location	5: 142045812-141953308	Physical location of FGF1_Gene
C42258	_5_44424541-44340854	Chromosome_5_Physical_Location	5: 44424541-44340854	Physical location of FGF10_Gene
C42259	_4_124105468-124176995	Chromosome_4_Physical_Location	4: 124105468-124176995	Physical location of FGF2_Gene
C42260	_8_16904045-16894705	Chromosome_8_Physical_Location	8: 16904045-16894705	Physical location of FGF20_Gene
C42261	_19_53951306-53953289	Chromosome_19_Physical_Location	19: 53951306-53953289	Physical location of FGF21_Gene
C42262	_11_69343129-69333917	Chromosome_11_Physical_Location	11: 69343129-69333917	Physical location of FGF3_Gene
C42263	_11_69299352-69296978	Chromosome_11_Physical_Location	11: 69299352-69296978	Physical location of FGF4_Gene
C42264	_4_81545011-81569338	Chromosome_4_Physical_Location	4: 81545011-81569338	Physical location of FGF5_Gene
C42265	_12_4425041-4413569	Chromosome_12_Physical_Location	12: 4425041-4413569	Physical location of FGF6_Gene
C42266	_15_47502751-47566815	Chromosome_15_Physical_Location	15: 47502751-47566815	Physical location of FGF7_Gene
C42267	_10_103525817-103519877	Chromosome_10_Physical_Location	10: 103525817-103519877	Physical location of FGF8_Gene
C42268	_13_21143875-21174187	Chromosome_13_Physical_Location	13: 21143875-21174187	Physical location of FGF9_Gene
C42269	_8_38445293-338389449	Chromosome_8_Physical_Location	8: 38445293-338389449	Physical location of FGFR1_Gene
C42270	_6_167383227-167424477	Chromosome_6_Physical_Location	6: 167383227-167424477	Physical location of FGFR1OP_Gene
C42271	_10_123347907-123227846	Chromosome_10_Physical_Location	10: 123347907-123227846	Physical location of FGFR2_Gene
C42272	_4_1762854-1777829	Chromosome_4_Physical_Location	4: 1762854-1777829	Physical location of FGFR3_Gene
C42273	_5_176556527-176457733	Chromosome_5_Physical_Location	5: 176556527-176457733	Physical location of FGFR4_Gene
C42274	_4_996082-1010516	Chromosome_4_Physical_Location	4: 996082-1010516	Physical location of FGFRL1_Gene
C42275	_1_27634715-27622953	Chromosome_1_Physical_Location	1: 27634715-27622953	Physical location of FGR_Gene
C42276	_3_61212164-59712987	Chromosome_3_Physical_Location	3: 61212164-59712987	Physical location of FHIT_Gene
C42277	_2_105513478-105435803	Chromosome_2_Physical_Location	2: 105513478-105435803	Physical location of FHL2_Gene
C42278	_11_65412586-65407787	Chromosome_11_Physical_Location	11: 65412586-65407787	Physical location of FIBP_Gene
C42279	_11_128069199-128187521	Chromosome_11_Physical_Location	11: 128069199-128187521	Physical location of FLI1_Gene
C42280	_3_114734183-114830960	Chromosome_3_Physical_Location	3: 114734183-114830960	Physical location of FLJ20174_Gene
C42281	_20_14266270-14252643	Chromosome_20_Physical_Location	20: 14266270-14252643	Physical location of FLRT3_Gene
C42282	_13_27967232-27773790	Chromosome_13_Physical_Location	13: 27967232-27773790	Physical location of FLT1_Gene
C42283	_13_27542750-27475753	Chromosome_13_Physical_Location	13: 27542750-27475753	Physical location of FLT3_Gene
C42284	_19_54669298-54681300	Chromosome_19_Physical_Location	19: 54669298-54681300	Physical location of FLT3LG_Gene
C42285	_5_180009172-179962148	Chromosome_5_Physical_Location	5: 180009172-179962148	Physical location of FLT4_Gene
C42286	_2_216126297-216050687	Chromosome_2_Physical_Location	2: 216126297-216050687	Physical location of FN1_Gene
C42287	_8_43030641-43060080	Chromosome_8_Physical_Location	8: 43030641-43060080	Physical location of FNTA_Gene
C42288	_14_64523260-64599123	Chromosome_14_Physical_Location	14: 64523260-64599123	Physical location of FNTB_Gene
C42289	_11_49186798-49124764	Chromosome_11_Physical_Location	11: 49186798-49124764	Physical location of FOLH1_Gene
C42290	_11_71578250-71585014	Chromosome_11_Physical_Location	11: 71578250-71585014	Physical location of FOLR1_Gene
C42291	_14_74815284-74818666	Chromosome_14_Physical_Location	14: 74815284-74818666	Physical location of FOS_Gene
C42292	_19_50663093-50670276	Chromosome_19_Physical_Location	19: 50663093-50670276	Physical location of FOSB_Gene
C42293	_11_65424573-65416268	Chromosome_11_Physical_Location	11: 65424573-65416268	Physical location of FOSL1_Gene
C42294	_2_28527430-28549167	Chromosome_2_Physical_Location	2: 28527430-28549167	Physical location of FOSL2_Gene
C42295	_14_28306038-28308622	Chromosome_14_Physical_Location	14: 28306038-28308622	Physical location of FOXG1B_Gene
C42296	Pseudoautosomal_Region	Chromosome_Structure	Pseudoautosomal Region	The human Y chromosome is composed of two different parts: a pseudoautosomal region that is homologous to a region of the X chromosome and which is responsible for sex chromosome pairing and a Y-specific part that encodes the sex determining gene.  Genes within the pseudoautosomal region are not sex linked.
C42297	Glucksberg_Scale	Clinical_Assessment_Tool	Glucksberg Scale|Glucksberg|Glucksberg GVHD Scale	The Glucksberg scale is a severity index for grading acute graft-versus-host disease (GVHD) after allogeneic marrow transplantation. This index is based on the results of an analysis in which distinct patterns in the peak severity of GVHD involvement in the skin, liver, and gut were correlated with the risks of transplant-related mortality (TRM) and treatment failure (defined as relapse or death).
C42298	Gracely_Pain_Intensity_Scale	Pain_Assessment_Tool	Gracely Pain Intensity Scale|Gracely Intensity Scale	The Gracely pain intensity scale is a visual analog scale of 0 to 20, used by a subject to define their pain intensity experience.  Together with the unpleasantness scale these tools serve to differentiate the patient's sensory perception of pain intensity from their affective experience of the pain's "unpleasant" quality.
C42299	Gracely_Pain_Unpleasantness_Scale	Pain_Assessment_Tool	Gracely Pain Unpleasantness Scale|Gracely Pain Discomfort Scale|Gracely Pain Effect Scale|Gracely Unpleasantness Scale	The Gracely Pain Unpleasantness Scale is a visual analog scale of 0 to 20 used by a subject to define their pain unpleasantness experience.  Together with the intensity scale these tools serve to differentiate the patient's sensory perception of pain intensity from their affective experience of the pain's "unpleasant" quality.
C42300	Head_Ears_Eyes_Nose_and_Throat	Body_Region	Head, Ears, Eyes, Nose and Throat|HEENT	HEENT is the Head, Ears, Eyes, Nose and Throat, and is referred to as a body system on a physical or medical examination.  The term is typically used as 'HEENT' in a physician or caregiver notes.
C42301	Chairperson	Person	Chairperson|Chair|Chairman|Chairwoman	A chairperson is the officer who presides at the meetings of an organization, committee, or other organizational structure.
C42302	Chromosome_1_Physical_Location	Gene_Physical_Location	Chromosome 1 Physical Location
C42303	Chromosome_2_Physical_Location	Gene_Physical_Location	Chromosome 2 Physical Location
C42304	Chromosome_3_Physical_Location	Gene_Physical_Location	Chromosome 3 Physical Location
C42305	Chromosome_4_Physical_Location	Gene_Physical_Location	Chromosome 4 Physical Location
C42306	Chromosome_5_Physical_Location	Gene_Physical_Location	Chromosome 5 Physical Location
C42307	Chromosome_6_Physical_Location	Gene_Physical_Location	Chromosome 6 Physical Location
C42308	Chromosome_7_Physical_Location	Gene_Physical_Location	Chromosome 7 Physical Location
C42309	Chromosome_8_Physical_Location	Gene_Physical_Location	Chromosome 8 Physical Location
C42310	Chromosome_9_Physical_Location	Gene_Physical_Location	Chromosome 9 Physical Location
C42311	Chromosome_10_Physical_Location	Gene_Physical_Location	Chromosome 10 Physical Location
C42312	Chromosome_11_Physical_Location	Gene_Physical_Location	Chromosome 11 Physical Location
C42313	Chromosome_12_Physical_Location	Gene_Physical_Location	Chromosome 12 Physical Location
C42314	Chromosome_13_Physical_Location	Gene_Physical_Location	Chromosome 13 Physical Location
C42315	Chromosome_14_Physical_Location	Gene_Physical_Location	Chromosome 14 Physical Location
C42316	Chromosome_15_Physical_Location	Gene_Physical_Location	Chromosome 15 Physical Location
C42317	Chromosome_16_Physical_Location	Gene_Physical_Location	Chromosome 16 Physical Location
C42318	Chromosome_17_Physical_Location	Gene_Physical_Location	Chromosome 17 Physical Location
C42319	Chromosome_18_Physical_Location	Gene_Physical_Location	Chromosome 18 Physical Location
C42320	Chromosome_19_Physical_Location	Gene_Physical_Location	Chromosome 19 Physical Location
C42321	Chromosome_20_Physical_Location	Gene_Physical_Location	Chromosome 20 Physical Location
C42322	Chromosome_21_Physical_Location	Gene_Physical_Location	Chromosome 21 Physical Location
C42323	Chromosome_22_Physical_Location	Gene_Physical_Location	Chromosome 22 Physical Location
C42324	Chromosome_X_Physical_Location	Gene_Physical_Location	Chromosome X Physical Location
C42325	Chromosome_Y_Physical_Location	Gene_Physical_Location	Chromosome Y Physical Location
C42327	CHUK_Gene	Signaling_Pathway_Gene	CHUK Gene|CHUK|Conserved Helix-Loop-Helix Ubiquitous Kinase Gene|IKBKA|IKK-Alpha|IKK1|IKKA|NFKBIKA|TCF16	Widely expressed human CHUK Gene (Ser/Thr IKBK Family) encodes 745-aa 85-kDa Conserved Helix-Loop-Helix Ubiquitous Kinase, an autophosphorylated cytoplasmic protein found in active heterodimer with IKK-beta bound to MAP3K14/NIK, MEKK1, IKAP, IKB-alpha-p65-p50 complex, and in complex with NCOA2, NCOA3, IKKB, IKBKG, and CREBBP. CHUK may interact with TRAF2, IKK-gamma/NEMO, and TRPC4AP. Inactivated by PP2A and activated by MAP3K14/NIK, AKT, and MEKK1, CHUK (or IKBKB) serine phosphorylates NFKB inhibitors (I-Kappa-Bs, NFKBIA or NFKBIB) leading to dissociation from cytoplasmically-trapped NFKB and ubiquitinated inhibitor degradation. Activated NFKB translocates to the nucleus, binds at kappa-B DNA binding motifs, and regulates transcription of target genes. CHUK also phosphorylates NCOA3. (NCI)
C42328	Conserved_Helix-Loop-Helix_Ubiquitous_Kinase	Signaling_Protein	Conserved Helix-Loop-Helix Ubiquitous Kinase|CHUK|I Kappa-B Kinase Alpha|I-Kappa-B Kinase 1|IKBKA|IKK-Alpha|IKK1|IKKA|IKappaB Kinase|Inhibitor of Nuclear Factor Kappa-B Kinase Alpha Subunit|NFKBIKA|Nuclear Factor NFKappaB Inhibitor Kinase Alpha	Widely expressed by human CHUK Gene (Ser/Thr IKBK Family), 745-aa 85-kDa Conserved Helix-Loop-Helix Ubiquitous Kinase is an autophosphorylated cytoplasmic protein found in active heterodimer with IKK-beta bound to MAP3K14/NIK, MEKK1, IKAP, IKB-alpha-p65-p50 complex, and in complex with NCOA2, NCOA3, IKKB, IKBKG, and CREBBP. CHUK may interact with TRAF2, IKK-gamma/NEMO, and TRPC4AP. Inactivated by PP2A and activated by MAP3K14/NIK, AKT, and MEKK1, CHUK (or IKBKB) serine phosphorylates NFKB inhibitors (I-Kappa-Bs, NFKBIA or NFKBIB) leading to dissociation from cytoplasmically-trapped NFKB and ubiquitinated inhibitor degradation. Activated NFKB translocates to the nucleus, binds at kappa-B DNA binding motifs, and regulates transcription of target genes. CHUK also phosphorylates NCOA3. (NCI)
C42331	African	Race	African	A person with African ancestral origins who self identifies, or is identified, as African. The concept does not refer to those of other ancestry, for example, European and South Asian. In practice, the term mainly refers to people originated from forty-eight sub-Saharan Africa nations; and excudes individuals from North Africa countries, e.g. such as Algeria, Morocco, Egypt, Tunisia with Arab and Berber ethnicity.
C42332	_13_40138734-40027817	Chromosome_13_Physical_Location	13: 40138734-40027817	Physical location of FOXO1A_Gene
C42333	_6_109897719-109108661	Chromosome_6_Physical_Location	6: 109897719-109108661	Physical location of FOXO3A_Gene
C42334	_19_56946962-56940839	Chromosome_19_Physical_Location	19: 56946962-56940839	Physical location of FPR1_Gene
C42335	_11_3786360-3804160	Chromosome_11_Physical_Location	11: 3786360-3804160	Physical location of FRAG1_Gene
C42336	_1_11256832-11100858	Chromosome_1_Physical_Location	1: 11256832-11100858	Physical location of FRAP1_Gene
C42337	_10_99069012-99071665	Chromosome_10_Physical_Location	10: 99069012-99071665	Physical location of FRAT1_Gene
C42338	_6_116488614-116369687	Chromosome_6_Physical_Location	6: 116488614-116369687	Physical location of FRK_Gene
C42339	_12_68150453-68255011	Chromosome_12_Physical_Location	12: 68150453-68255011	Physical location of FRS2_Gene
C42340	_6_41588608-41845892	Chromosome_6_Physical_Location	6: 41588608-41845892	Physical location of FRS3_Gene
C42341	_2_223346310-223260765	Chromosome_2_Physical_Location	2: 223346310-223260765	Physical location of FRSB_Gene
C42342	_19_627417-634389	Chromosome_19_Physical_Location	19: 627417-634389	Physical location of FSTL3_Gene
C42343	_15_89212889-89227691	Chromosome_15_Physical_Location	15: 89212889-89227691	Physical location of FURIN_Gene
C42344	_18_59185438-59148813	Chromosome_18_Physical_Location	18: 59185438-59148813	Physical location of FVT1_Gene
C42345	_6_112301320-112089178	Chromosome_6_Physical_Location	6: 112301320-112089178	Physical location of FYN_Gene
C42346	_17_39990451-39992433	Chromosome_17_Physical_Location	17: 39990451-39992433	Physical location of FZD2_Gene
C42347	_8_28407692-28477901	Chromosome_8_Physical_Location	8: 28407692-28477901	Physical location of FZD3_Gene
C42348	_11_86344081-86334370	Chromosome_11_Physical_Location	11: 86344081-86334370	Physical location of FZD4_Gene
C42349	_8_104380276-104414270	Chromosome_8_Physical_Location	8: 104380276-104414270	Physical location of FZD6_Gene
C42350	_2_202724816-202728666	Chromosome_2_Physical_Location	2: 202724816-202728666	Physical location of FZD7_Gene
C42351	_7_72292964-72295149	Chromosome_7_Physical_Location	7: 72292964-72295149	Physical location of FZD9_Gene
C42352	_22_40341854-40384543	Chromosome_22_Physical_Location	22: 40341854-40384543	Physical location of G22P1_Gene
C42353	_X_153339173-153323310	Chromosome_X_Physical_Location	X: 153339173-153323310	Physical location of G6PD_Gene
C42354	_12_55168448-55151004	Chromosome_12_Physical_Location	12: 55168448-55151004	Physical location of GA_Gene
C42355	_11_77806414-77603990	Chromosome_11_Physical_Location	11: 77806414-77603990	Physical location of GAB2_Gene
C42356	_1_201384254-201317962	Chromosome_1_Physical_Location	1: 201384254-201317962	Physical location of GAC1_Gene
C42357	_1_67862904-67866040	Chromosome_1_Physical_Location	1: 67862904-67866040	Physical location of GADD45A_Gene
C42358	_X_51945089-51951834	Chromosome_X_Physical_Location	X: 51945089-51951834	Physical location of GAGED3_Gene
C42359	_17_71582487-71585168	Chromosome_17_Physical_Location	17: 71582487-71585168	Physical location of GALR2_Gene
C42360	_11_22646230-22791123	Chromosome_11_Physical_Location	11: 22646230-22791123	Physical location of GAS2_Gene
C42361	_12_68039799-68070843	Chromosome_12_Physical_Location	12: 68039799-68070843	Physical location of GAS41_Gene
C42362	_16_88616509-88638880	Chromosome_16_Physical_Location	16: 88616509-88638880	Physical location of GAS8_Gene
C42363	_X_48401210-48408967	Chromosome_X_Physical_Location	X: 48401210-48408967	Physical location of GATA1_Gene
C42364	_4_73014923-72972448	Chromosome_4_Physical_Location	4: 73014923-72972448	Physical location of GC_Gene
C42365	_2_162834264-162824895	Chromosome_2_Physical_Location	2: 162834264-162824895	Physical location of GCG_Gene
C42366	_6_53517790-53470098	Chromosome_6_Physical_Location	6: 53517790-53470098	Physical location of GCLC_Gene
C42367	_1_94086987-94066034	Chromosome_1_Physical_Location	1: 94086987-94066034	Physical location of GCLM_Gene
C42368	_10_48059172-48045795	Chromosome_10_Physical_Location	10: 48059172-48045795	Physical location of GDF10_Gene
C42369	_20_33489441-33484563	Chromosome_20_Physical_Location	20: 33489441-33484563	Physical location of GDF5_Gene
C42370	_2_190752961-190745933	Chromosome_2_Physical_Location	2: 190752961-190745933	Physical location of GDF8_Gene
C42371	_5_132228124-132225180	Chromosome_5_Physical_Location	5: 132228124-132225180	Physical location of GDF9_Gene
C42372	_5_37875539-37851510	Chromosome_5_Physical_Location	5: 37875539-37851510	Physical location of GDNF_Gene
C42373	_9_132883652-132896636	Chromosome_9_Physical_Location	9: 132883652-132896636	Physical location of GFI1B_Gene
C42374	_8_21702292-21688429	Chromosome_8_Physical_Location	8: 21702292-21688429	Physical location of GFRA2_Gene
C42375	_17_59349930-59348295	Chromosome_17_Physical_Location	17: 59349930-59348295	Physical location of GH1_Gene
C42376	_5_42601723-42757736	Chromosome_5_Physical_Location	5: 42601723-42757736	Physical location of GHR_Gene
C42377	_20_35318706-35312903	Chromosome_20_Physical_Location	20: 35318706-35312903	Physical location of GHRH_Gene
C42378	_19_50863342-50877557	Chromosome_19_Physical_Location	19: 50863342-50877557	Physical location of GIPR_Gene
C42379	_17_24940735-24924620	Chromosome_17_Physical_Location	17: 24940735-24924620	Physical location of GIT1_Gene
C42380	_12_108896820-108830329	Chromosome_12_Physical_Location	12: 108896820-108830329	Physical location of GIT2_Gene
C42381	_12_56140201-56152312	Chromosome_12_Physical_Location	12: 56140201-56152312	Physical location of GLI_Gene
C42382	_2_121266089-121465186	Chromosome_2_Physical_Location	2: 121266089-121465186	Physical location of GLI2_Gene
C42383	_7_42036134-41776911	Chromosome_7_Physical_Location	7: 42036134-41776911	Physical location of GLI3_Gene
C42384	_9_36126742-36153903	Chromosome_9_Physical_Location	9: 36126742-36153903	Physical location of GLIPR2_Gene
C42385	_1_92476565-92424068	Chromosome_1_Physical_Location	1: 92476565-92424068	Physical location of GLMN_Gene
C42386	_19_52874031-52898291	Chromosome_19_Physical_Location	19: 52874031-52898291	Physical location of GLTSCR1_Gene
C42387	_19_52940620-52952127	Chromosome_19_Physical_Location	19: 52940620-52952127	Physical location of GLTSCR2_Gene
C42388	_6_24883143-24894257	Chromosome_6_Physical_Location	6: 24883143-24894257	Physical location of GMNN_Gene
C42389	_7_2657200-2540984	Chromosome_7_Physical_Location	7: 2657200-2540984	Physical location of GNA12_Gene
C42390	_7_79408791-79493376	Chromosome_7_Physical_Location	7: 79408791-79493376	Physical location of GNAI1_Gene
C42391	_3_50248652-50271291	Chromosome_3_Physical_Location	3: 50248652-50271291	Physical location of GNAI2_Gene
C42392	_1_109803343-109849017	Chromosome_1_Physical_Location	1: 109803343-109849017	Physical location of GNAI3_Gene
C42393	_9_77875746-77564747	Chromosome_9_Physical_Location	9: 77875746-77564747	Physical location of GNAQ_Gene
C42394	_20_56848190-56919642	Chromosome_20_Physical_Location	20: 56848190-56919642	Physical location of GNAS_Gene
C42395	_22_21737223-21791778	Chromosome_22_Physical_Location	22: 21737223-21791778	Physical location of GNAZ_Gene
C42396	_1_1854657-1748892	Chromosome_1_Physical_Location	1: 1854657-1748892	Physical location of GNB1_Gene
C42397	_7_99916026-99921443	Chromosome_7_Physical_Location	7: 99916026-99921443	Physical location of GNB2_Gene
C42398	_12_6819636-6826818	Chromosome_12_Physical_Location	12: 6819636-6826818	Physical location of GNB3_Gene
C42399	_8_25337836-25332693	Chromosome_8_Physical_Location	8: 25337836-25332693	Physical location of GNRH1_Gene
C42400	_20_2972268-2974391	Chromosome_20_Physical_Location	20: 2972268-2974391	Physical location of GNRH2_Gene
C42401	_4_68450570-68434964	Chromosome_4_Physical_Location	4: 68450570-68434964	Physical location of GNRHR_Gene
C42402	_10_101180336-101146618	Chromosome_10_Physical_Location	10: 101180336-101146618	Physical location of GOT1_Gene
C42403	_16_57325641-57298538	Chromosome_16_Physical_Location	16: 57325641-57298538	Physical location of GOT2_Gene
C42404	_1_163791526-163753740	Chromosome_1_Physical_Location	1: 163791526-163753740	Physical location of GPA33_Gene
C42405	_19_39547909-39583076	Chromosome_19_Physical_Location	19: 39547909-39583076	Physical location of GPI_Gene
C42406	_2_128119977-128126443	Chromosome_2_Physical_Location	2: 128119977-128126443	Physical location of GPR17_Gene
C42407	_17_38087371-38084961	Chromosome_17_Physical_Location	17: 38087371-38084961	Physical location of GPR2_Gene
C42408	_19_55965670-55966740	Chromosome_19_Physical_Location	19: 55965670-55966740	Physical location of GPR32_Gene
C42409	_2_133008348-133236911	Chromosome_2_Physical_Location	2: 133008348-133236911	Physical location of GPR39_Gene
C42410	_19_868503-872001	Chromosome_19_Physical_Location	19: 868503-872001	Physical location of GPR54_Gene
C42411	_14_90790022-90769965	Chromosome_14_Physical_Location	14: 90790022-90769965	Physical location of GPR68_Gene
C42412	_17_69939262-69955163	Chromosome_17_Physical_Location	17: 69939262-69955163	Physical location of GPRC5C_Gene
C42413	_4_3002549-3079479	Chromosome_4_Physical_Location	4: 3002549-3079479	Physical location of GPRK2L_Gene
C42414	_10_120957193-121205126	Chromosome_10_Physical_Location	10: 120957193-121205126	Physical location of GPRK5_Gene
C42415	_5_176786389-176802456	Chromosome_5_Physical_Location	5: 176786389-176802456	Physical location of GPRK6_Gene
C42416	_3_142979741-143020030	Chromosome_3_Physical_Location	3: 142979741-143020030	Physical location of GPRK7_Gene
C42417	_17_77603052-77608635	Chromosome_17_Physical_Location	17: 77603052-77608635	Physical location of GPS1_Gene
C42418	_8_145700231-145703357	Chromosome_8_Physical_Location	8: 145700231-145703357	Physical location of GPT_Gene
C42419	_16_45475809-45522699	Chromosome_16_Physical_Location	16: 45475809-45522699	Physical location of GPT2_Gene
C42420	_3_129777627-129773542	Chromosome_3_Physical_Location	3: 129777627-129773542	Physical location of GR6_Gene
C42421	_17_18890997-18865810	Chromosome_17_Physical_Location	17: 18890997-18865810	Physical location of GRAP_Gene
C42422	_7_50624473-50434254	Chromosome_7_Physical_Location	7: 50624473-50434254	Physical location of GRB10_Gene
C42423	_2_165303867-165174840	Chromosome_2_Physical_Location	2: 165303867-165174840	Physical location of GRB14_Gene
C42424	_17_70913384-70825753	Chromosome_17_Physical_Location	17: 70913384-70825753	Physical location of GRB2_Gene
C42425	_17_35147744-35157063	Chromosome_17_Physical_Location	17: 35147744-35157063	Physical location of GRB7_Gene
C42426	_X_122043693-122348328	Chromosome_X_Physical_Location	X: 122043693-122348328	Physical location of GRIA3_Gene
C42427	_6_146392112-146800427	Chromosome_6_Physical_Location	6: 146392112-146800427	Physical location of GRM1_Gene
C42428	_11_88420838-87881006	Chromosome_11_Physical_Location	11: 88420838-87881006	Physical location of GRM5_Gene
C42429	_5_178354730-178337938	Chromosome_5_Physical_Location	5: 178354730-178337938	Physical location of GRM6_Gene
C42430	_18_55038380-55048983	Chromosome_18_Physical_Location	18: 55038380-55048983	Physical location of GRP_Gene
C42431	_1_109942484-109948409	Chromosome_1_Physical_Location	1: 109942484-109948409	Physical location of GSTM1_Gene
C42432	_11_67107862-67110699	Chromosome_11_Physical_Location	11: 67107862-67110699	Physical location of GSTP1_Gene
C42433	_22_22708785-22700695	Chromosome_22_Physical_Location	22: 22708785-22700695	Physical location of GSTT1_Gene
C42434	_14_80757328-80716147	Chromosome_14_Physical_Location	14: 80757328-80716147	Physical location of GTF2A1_Gene
C42435	_15_57736987-57718358	Chromosome_15_Physical_Location	15: 57736987-57718358	Physical location of GTF2A2_Gene
C42436	_1_89069241-89030638	Chromosome_1_Physical_Location	1: 89069241-89030638	Physical location of GTF2B_Gene
C42437	_3_121952059-121984605	Chromosome_3_Physical_Location	3: 121952059-121984605	Physical location of GTF2E1_Gene
C42438	_8_30635274-30555575	Chromosome_8_Physical_Location	8: 30635274-30555575	Physical location of GTF2E2_Gene
C42439	_19_6344184-6330581	Chromosome_19_Physical_Location	19: 6344184-6330581	Physical location of GTF2F1_Gene
C42440	_13_44592672-44756237	Chromosome_13_Physical_Location	13: 44592672-44756237	Physical location of GTF2F2_Gene
C42441	_11_18300719-18345153	Chromosome_11_Physical_Location	11: 18300719-18345153	Physical location of GTF2H1_Gene
C42442	_16_27468775-27379570	Chromosome_16_Physical_Location	16: 27468775-27379570	Physical location of GTF3C1_Gene
C42443	_2_27478096-27460374	Chromosome_2_Physical_Location	2: 27478096-27460374	Physical location of GTF3C2_Gene
C42444	_2_197489931-197454606	Chromosome_2_Physical_Location	2: 197489931-197454606	Physical location of GTF3C3_Gene
C42445	_9_132575282-132594368	Chromosome_9_Physical_Location	9: 132575282-132594368	Physical location of GTF3C4_Gene
C42446	_9_132935667-132963441	Chromosome_9_Physical_Location	9: 132935667-132963441	Physical location of GTF3C5_Gene
C42447	_11_106394381-106063120	Chromosome_11_Physical_Location	11: 106394381-106063120	Physical location of GUCY1A2_Gene
C42448	_4_156945483-157009387	Chromosome_4_Physical_Location	4: 156945483-157009387	Physical location of GUCY1A3_Gene
C42449	_13_50538143-50466770	Chromosome_13_Physical_Location	13: 50538143-50466770	Physical location of GUCY1B2_Gene
C42450	_4_157037820-157085661	Chromosome_4_Physical_Location	4: 157037820-157085661	Physical location of GUCY1B3_Gene
C42451	_4_145419449-145388062	Chromosome_4_Physical_Location	4: 145419449-145388062	Physical location of GYPA_Gene
C42452	_11_1979276-1973489	Chromosome_11_Physical_Location	11: 1979276-1973489	Physical location of H19_Gene
C42453	_11_118471387-118469797	Chromosome_11_Physical_Location	11: 118471387-118469797	Physical location of H2AX_Gene
C42454	_2_172604482-172674045	Chromosome_2_Physical_Location	2: 172604482-172674045	Physical location of HAT1_Gene
C42455	_20_30103718-30153320	Chromosome_20_Physical_Location	20: 30103718-30153320	Physical location of HCK_Gene
C42456	_1_32426801-32468317	Chromosome_1_Physical_Location	1: 32426801-32468317	Physical location of HDAC1_Gene
C42457	_6_114398967-114368621	Chromosome_6_Physical_Location	6: 114398967-114368621	Physical location of HDAC2_Gene
C42458	_5_140996596-140980627	Chromosome_5_Physical_Location	5: 140996596-140980627	Physical location of HDAC3_Gene
C42459	_2_240058897-239706636	Chromosome_2_Physical_Location	2: 240058897-239706636	Physical location of HDAC4_Gene
C42460	_17_39556512-39509647	Chromosome_17_Physical_Location	17: 39556512-39509647	Physical location of HDAC5_Gene
C42461	_X_48416735-48439629	Chromosome_X_Physical_Location	X: 48416735-48439629	Physical location of HDAC6_Gene
C42462	_7_81044003-80976096	Chromosome_7_Physical_Location	7: 81044003-80976096	Physical location of HGF_Gene
C42463	_17_77261425-77279553	Chromosome_17_Physical_Location	17: 77261425-77279553	Physical location of HGS_Gene
C42464	_14_61231992-61284729	Chromosome_14_Physical_Location	14: 61231992-61284729	Physical location of HIF1A_Gene
C42465	_2_74971437-75032136	Chromosome_2_Physical_Location	2: 74971437-75032136	Physical location of HK2_Gene
C42466	_1_6574377-6583605	Chromosome_1_Physical_Location	1: 6574377-6583605	Physical location of HKR3_Gene
C42467	_6_30018310-30021042	Chromosome_6_Physical_Location	6: 30018310-30021042	Physical location of HLA-A_Gene
C42468	_6_33151738-33162954	Chromosome_6_Physical_Location	6: 33151738-33162954	Physical location of HLA-DPB1_Gene
C42469	_12_121726224-121724184	Chromosome_12_Physical_Location	12: 121726224-121724184	Physical location of HM74_Gene
C42470	_6_34312628-34321986	Chromosome_6_Physical_Location	6: 34312628-34321986	Physical location of HMGA1_Gene
C42471	_12_64504458-64646266	Chromosome_12_Physical_Location	12: 64504458-64646266	Physical location of HMGA2_Gene
C42472	_13_29938013-29931997	Chromosome_13_Physical_Location	13: 29938013-29931997	Physical location of HMGB1_Gene
C42473	_4_174630322-174627518	Chromosome_4_Physical_Location	4: 174630322-174627518	Physical location of HMGB2_Gene
C42474	_X_149822337-149827902	Chromosome_X_Physical_Location	X: 149822337-149827902	Physical location of HMGB3_Gene
C42475	_21_39642835-39636112	Chromosome_21_Physical_Location	21: 39642835-39636112	Physical location of HMGN1_Gene
C42476	_1_26483139-26486599	Chromosome_1_Physical_Location	1: 26483139-26486599	Physical location of HMGN2_Gene
C42477	_6_80001174-79967683	Chromosome_6_Physical_Location	6: 80001174-79967683	Physical location of HMGN3_Gene
C42478	_6_26646551-26655144	Chromosome_6_Physical_Location	6: 26646551-26655144	Physical location of HMGN4_Gene
C42479	_5_162820241-162851525	Chromosome_5_Physical_Location	5: 162820241-162851525	Physical location of HMMR_Gene
C42480	_2_177903035-177909534	Chromosome_2_Physical_Location	2: 177903035-177909534	Physical location of HNRPA3_Gene
C42481	_5_177564147-177570788	Chromosome_5_Physical_Location	5: 177564147-177570788	Physical location of HNRPAB_Gene
C42482	_10_102880252-102887536	Chromosome_10_Physical_Location	10: 102880252-102887536	Physical location of HOX11_Gene
C42483	_7_26993083-26983451	Chromosome_7_Physical_Location	7: 26993083-26983451	Physical location of HOXA10_Gene
C42484	_7_26978389-26975298	Chromosome_7_Physical_Location	7: 26978389-26975298	Physical location of HOXA9_Gene
C42485	_12_52697103-52710865	Chromosome_12_Physical_Location	12: 52697103-52710865	Physical location of HOXC6_Gene
C42486	_16_70646027-70652455	Chromosome_16_Physical_Location	16: 70646027-70652455	Physical location of HP_Gene
C42487	_1_33021191-33029340	Chromosome_1_Physical_Location	1: 33021191-33029340	Physical location of HPCA_Gene
C42488	_16_70665292-70668646	Chromosome_16_Physical_Location	16: 70665292-70668646	Physical location of HPR_Gene
C42489	_X_133319777-133360216	Chromosome_X_Physical_Location	X: 133319777-133360216	Physical location of HPRT1_Gene
C42490	_4_84613484-84570794	Chromosome_4_Physical_Location	4: 84613484-84570794	Physical location of HPSE_Gene
C42491	_11_525550-522242	Chromosome_11_Physical_Location	11: 525550-522242	Physical location of HRAS_Gene
C42492	_5_175042318-475044164	Chromosome_5_Physical_Location	5: 175042318-475044164	Physical location of HRH2_Gene
C42493	_12_115781952-115761748	Chromosome_12_Physical_Location	12: 115781952-115761748	Physical location of HRK_Gene
C42494	_16_80656364-80689638	Chromosome_16_Physical_Location	16: 80656364-80689638	Physical location of HSD17B2_Gene
C42495	_1_159492238-159514266	Chromosome_1_Physical_Location	1: 159492238-159514266	Physical location of HSD17B7_Gene
C42496	_7_75576574-75578263	Chromosome_7_Physical_Location	7: 75576574-75578263	Physical location of HSPB1_Gene
C42497	_11_65236065-65243651	Chromosome_11_Physical_Location	11: 65236065-65243651	Physical location of HTATIP_Gene
C42498	_11_20341924-20361904	Chromosome_11_Physical_Location	11: 20341924-20361904	Physical location of HTATIP2_Gene
C42499	_13_46368176-46305514	Chromosome_13_Physical_Location	13: 46368176-46305514	Physical location of HTR2A_Gene
C42500	_11_113351120-113366245	Chromosome_11_Physical_Location	11: 113351120-113366245	Physical location of HTR3_Gene
C42501	_11_118433122-118420110	Chromosome_11_Physical_Location	11: 118433122-118420110	Physical location of HYOU1_Gene
C42502	_19_10242779-10258291	Chromosome_19_Physical_Location	19: 10242779-10258291	Physical location of ICAM1_Gene
C42503	_17_59437839-59433688	Chromosome_17_Physical_Location	17: 59437839-59433688	Physical location of ICAM2_Gene
C42504	_19_10311307-10305452	Chromosome_19_Physical_Location	19: 10311307-10305452	Physical location of ICAM3_Gene
C42505	_2_8772711-8775181	Chromosome_2_Physical_Location	2: 8772711-8775181	Physical location of ID2_Gene
C42506	_11_303853-305272	Chromosome_11_Physical_Location	11: 303853-305272	Physical location of IFITM1_Gene
C42507	_9_21358075-21357423	Chromosome_9_Physical_Location	9: 21358075-21357423	Physical location of IFNA13_Gene
C42508	_9_21375396-21374254	Chromosome_9_Physical_Location	9: 21375396-21374254	Physical location of IFNA2_Gene
C42509	_21_33619084-33653999	Chromosome_21_Physical_Location	21: 33619084-33653999	Physical location of IFNAR1_Gene
C42510	_21_33524101-33558697	Chromosome_21_Physical_Location	21: 33524101-33558697	Physical location of IFNAR2_Gene
C42511	_12_66839770-66834816	Chromosome_12_Physical_Location	12: 66839770-66834816	Physical location of IFNG_Gene
C42512	_6_137582200-137560315	Chromosome_6_Physical_Location	6: 137582200-137560315	Physical location of IFNGR1_Gene
C42513	_21_33697072-33731696	Chromosome_21_Physical_Location	21: 33697072-33731696	Physical location of IFNGR2_Gene
C42514	_9_21132144-21130631	Chromosome_9_Physical_Location	9: 21132144-21130631	Physical location of IFNW1_Gene
C42515	_X_69136812-69169146	Chromosome_X_Physical_Location	X: 69136812-69169146	Physical location of IGBP1_Gene
C42516	_12_101376791-101295444	Chromosome_12_Physical_Location	12: 101376791-101295444	Physical location of IGF1_Gene
C42517	_15_97010288-97319134	Chromosome_15_Physical_Location	15: 97010288-97319134	Physical location of IGF1R_Gene
C42518	_11_2116578-2110532	Chromosome_11_Physical_Location	11: 2116578-2110532	Physical location of IGF2_Gene
C42519	_6_160360542-160497994	Chromosome_6_Physical_Location	6: 160360542-160497994	Physical location of IGF2R_Gene
C42520	_7_45701327-45706499	Chromosome_7_Physical_Location	7: 45701327-45706499	Physical location of IGFBP1_Gene
C42521	_2_217323633-217354662	Chromosome_2_Physical_Location	2: 217323633-217354662	Physical location of IGFBP2_Gene
C42522	_7_45734052-45725189	Chromosome_7_Physical_Location	7: 45734052-45725189	Physical location of IGFBP3_Gene
C42523	_17_35853236-35867457	Chromosome_17_Physical_Location	17: 35853236-35867457	Physical location of IGFBP4_Gene
C42524	_2_217385777-217362335	Chromosome_2_Physical_Location	2: 217385777-217362335	Physical location of IGFBP5_Gene
C42525	_12_51777716-51782391	Chromosome_12_Physical_Location	12: 51777716-51782391	Physical location of IGFBP6_Gene
C42526	_10_203334234-203329343	Chromosome_10_Physical_Location	10: 203334234-203329343	Physical location of IL10_Gene
C42527	_21_33560542-33591390	Chromosome_21_Physical_Location	21: 33560542-33591390	Physical location of IL10RB_Gene
C42528	_19_60573626-60567569	Chromosome_19_Physical_Location	19: 60573626-60567569	Physical location of IL11_Gene
C42529	_9_34643932-34651884	Chromosome_9_Physical_Location	9: 34643932-34651884	Physical location of IL11RA_Gene
C42530	_3_161189331-161196508	Chromosome_3_Physical_Location	3: 161189331-161196508	Physical location of IL12A_Gene
C42531	_5_158690059-158674369	Chromosome_5_Physical_Location	5: 158690059-158674369	Physical location of IL12B_Gene
C42532	Unit_of_International_System_of_Units	Unit_of_Measure	Unit of International System of Units|IU|SI Unit	A base or derived unit of weight or measure that belongs to the decimal International System of Units (Systeme International d'Unites, SI) derived from and extending the metric system.
C42533	Base_Unit_of_International_System_of_Units	Unit_of_International_System_of_Units	Base Unit of International System of Units|Base SI Unit	The base units are a choice of seven well-defined units within the International System of Units (Systeme International d'Unites, SI), which by convention are regarded as dimensionally independent and therefore defined in an absolute way without referring to any other units: the meter, the kilogram, the second, the ampere, the kelvin, the mole, and the candela. The base units are consistent with the part of the metric system called the MKS system.
C42534	Derived_Unit_of_International_System_of_Units	Unit_of_International_System_of_Units	Derived Unit of International System of Units|Derived SI Unit	Derived units of the International System of Units (Systeme International d'Unites, SI) are those formed by combining base SI units according to the algebraic relations linking the corresponding quantities. The names and symbols of some of the units thus formed can be replaced by special names and symbols which can themselves be used to form expressions and symbols of other derived units.
C42535	Second_Unit_of_Time	Base_Unit_of_International_System_of_Units|Unit_of_Time	Second|Sec|Seconde|Segundo|Sekund|Sekunda|s	The second is the unit of time, one of the seven base units of the International System of Units (Systeme International d'Unites, SI). The second is the duration of 919 263 177 0 periods of the specified light radiation corresponding to the transition between the two hyperfine levels of the ground state of the caesium 133 atom in its ground state at 0 K. According to the convention, 60 seconds constitute one minute; 3,600 seconds constitute one hour. Abbreviation Sec. is acceptable in non-scientific usage only.
C42536	Ampere	Base_Unit_of_International_System_of_Units	Ampere|A|amp	One of the seven base units of the International System of Units (Systeme International d'Unites, SI), the unit of electric current, named after the French physicist Andre Ampere. It is that constant current which, if maintained in two straight parallel conductors of infinite length and zero diameter separated by one meter in a vacuum, would produce between these conductors a force equal to 2x10(e)7 newton per meter of length. This is dependent upon the definitions of the meter, kilogram, and second. One ampere represents 6.24 x 10(e+18) unit electric charge carriers, such as electrons, passing a specified fixed point in one second.
C42537	Kelvin	Base_Unit_of_International_System_of_Units|Unit_of_Temperature	Kelvin|Degree Kelvin|K	The kelvin is the basic unit of thermodynamic temperature, one of the seven base units of the International System of Units (Systeme International d'Unites, SI). It is 1/273.16th of the thermodynamic temperature of the triple point of water, named after the Scottish mathematician and physicist William Thomson 1st Lord Kelvin. This sets the size of the kelvin unit for temperature differences and defines the thermodynamic temperature of an equilibrium mixture of waters ice-liquid-vapor as 273.16 K, where 0 K is the lowest possible temperature ("absolute zero").
C42538	Candela	Base_Unit_of_International_System_of_Units	Candela|cd	The candela is the basic unit of luminous intensity, one of the seven base units of the International System of Units (Systeme International d'Unites, SI). It is the luminous intensity in a given direction of a monochromatic light small source at 540 terahertz emitting 1/683 watt per steradian in that direction. This is dependent upon the definitions of the meter, kilogram, and second.
C42539	Mole	Base_Unit_of_International_System_of_Units|Unit_of_Amount_of_Substance|Unit_of_Potency	Mole|MOLE|Mol	The the basic unit of substance, one of the seven base units of the International System of Units (Systeme International d'Unites, SI). It is the amount of substance that contains as many elementary units as there are atoms in 0.012 kg of carbon-12. When the mole is used, the elementary entities must be specified and may be atoms, molecules, ions, electrons, other particles, or specified groups of such particles.
C42540	Metric_System	Conceptual_Entities	Metric System|MS	An international decimal system of weights and measures, in which the basic units are the meter for length, the gram for weight, and the liter for volume. The metric system units have to satisfy three conditions: one fundamental unit is defined for each quantity; multiples and fractions of fundamental units are created by adding prefixes (denoting powers of ten) to the names of the defined units; the fundamental units are defined rationally and are related to each other in a rational fashion. The metric system evolved into the International System of Units (Systeme International d'Unites, SI).
C42541	International_System_of_Units	Conceptual_Entities	International System of Units|Modern Metric System|SI	The International System of Units (Systeme International d'Unites, SI) is a decimal system of weights and measures derived from and extending the metric system of units established through the Treaty of the Meter (Convention du Metre) signed in Paris in 1875 and currently signed by 48 nations including all the major industrialized countries. The SI is maintained by the International Bureau of Weights and Measures (BIPM, for Bureau International des Poids et Mesures), and is updated every few years by an international conference, the General Conference on Weights and Measures (CGPM, for Conference Generale des Poids et Mesures). SI has a short list of base units defined in an absolute way without referring to any other units: the metre, the kilogram, the second, the ampere, the kelvin, the mole, and the candela. The base units are consistent with the part of the metric system called the MKS system.
C42542	International_Bureau_of_Weights_and_Measures	Other_Agency_or_Organization	International Bureau of Weights and Measures|BIPM	International Bureau of Weights and Measures (BIPM, for Bureau International des Poids et Mesures) is the agency which was given authority by diplomatic treaty the Convention of the Metre to maintain the International System of Units and to act in matters of world metrology, particularly concerning the demand for measurement standards of ever increasing accuracy, range and diversity, and the need to demonstrate equivalence between national measurement standards.
C42543	Radian	Derived_Unit_of_International_System_of_Units	Radian|Rad	A SI-derived unit of plane angle measurement defined and named by James Thomson in 1873. One radian is the plane angle between two radii of a circle that cuts off on the circumference an arc equal in length to the radius. There are 2pi radians in a complete circle. SI units: m/m = 1.
C42544	Steradian	Derived_Unit_of_International_System_of_Units	Steradian|str	A SI derived unit of solid angle measurement. One steradian is the solid angle that, having its vertex in the center of a sphere, cuts off an area on the surface of the sphere equal to that of a square with sides of length equal to the radius of the sphere. It is equal to 0.25 of the solid angle around a point, 0.079 58 sphere, 0.159 16 hemisphere, 0.636 6 spherical right angle, 3,282.8 square degrees. The solid angle corresponding to all of space being subtended is 4pi steradians.
C42545	Hertz	Derived_Unit_of_International_System_of_Units	Hertz|Hz	The SI derived unit of frequency; equal to one oscillation per second.
C42546	Newton	Derived_Unit_of_International_System_of_Units	Newton|N	A SI derived unit of force. The force which, when applied in a vacuum to a body having a mass of one kilogram, causes an acceleration of one meter/sec(2). It is equal to 10(e+5) dyne.
C42547	Pascal	Derived_Unit_of_International_System_of_Units	Pascal|Pa	A SI derived unit of pressure equivalent to one newton per square meter or 10 bars or to 1.45x10(e-4) pounds per square inch.
C42548	Joule	Derived_Unit_of_International_System_of_Units	Joule|J|Watt second	The fundamental unit of electrical, mechanical, and thermal energy (as well as work and quantity of heat) in the SI system, equal to the work done when a force of one newton acts through a distance of one meter or the work done when a current of one ampere passes through a resistance of one ohm for one second. Joule is equal to 0.23889 gram-calorie (mean).
C42549	Watt	Derived_Unit_of_International_System_of_Units	Watt|W	Watt is an SI derived unit of power equal to one joule per second; the power dissipated by a current of one ampere flowing across a resistance of one ohm. Equal to 1/746 of horsepower.
C42550	Coulomb	Derived_Unit_of_International_System_of_Units	Coulomb|Amp-second|Ampere second|C	The SI derived unit of quantity of electricity, equal to the quantity of charge transferred in one second across a conductor in which there is a constant current of one ampere.
C42551	Volt	Derived_Unit_of_International_System_of_Units	Volt|V	The SI derived unit of electric potential and electromotive force, equal to the difference of electric potential between two points on a conducting wire carrying a constant current of one ampere when the power dissipated between the points is one watt, equivalent to the potential difference across a resistance of one ohm when one ampere of current flows through it.
C42552	Farad	Derived_Unit_of_International_System_of_Units	Farad|F	The SI unit of capacitance equal to the capacitance of a capacitor having an equal and opposite charge of one coulomb on each plate and a potential difference of one volt between the plates.
C42553	Sievert	Derived_Unit_of_International_System_of_Units	Sievert	Sievert (Sv) is the SI derived unit of equivalent radiation dose. One Sv is received when the actual absorbed dose of ionizing radiation, after being multiplied by the dimensionless factors Q (quality factor) and N (the product of any other multiplying factors), is one joule per kilogram. In this scheme, the relationship between the absorbed dose of radiation D and the dose equivalent H is, therefore, given by H = QND. Both Q and N are stipulated by the International Commission on Radiological Protection. Also known as the relative biological efficiency, Q depends on the nature of the radiation and has a value of one for x rays, gamma rays, and beta particles; 10 for neutrons; and 20 for alpha particles. N is a factor that takes into account the distribution of energy throughout the dose. One Sv is equal to 100 rem.
C42554	Ohm	Derived_Unit_of_International_System_of_Units	Ohm	A unit of electrical resistance equal to the resistance between two points on a conductor when a potential difference of one volt between them produces a current of one ampere. Ohm is also used to measure impedance and reactance for complex resistance. A measurement in ohms is the reciprocal of a measurement in siemens.
C42555	Siemens	Derived_Unit_of_International_System_of_Units	Siemens|Reciprocal ohm|S|mho	A unit of electrical conductance, admittance, and susceptance. A conductor has a conductance of one siemens if an electrical potential difference of one volt produces a one ampere current in it. The conductance in siemens is the reciprocal of its resistance in ohms.
C42556	Weber	Derived_Unit_of_International_System_of_Units	Weber|Wb	The SI derived unit of magnetic flux, equal to the flux that produces in a circuit of one turn an electromotive force of one volt, when the flux is uniformly reduced to zero within one second.
C42557	Tesla	Derived_Unit_of_International_System_of_Units	Tesla|T	The unit of magnetic flux density in the SI, equal to the magnitude of the magnetic field vector necessary to produce a force of one newton on a charge of one coulomb moving perpendicular to the direction of the magnetic field vector with a velocity of one meter per second. It is equivalent to one weber per square meter.
C42558	Henry	Derived_Unit_of_International_System_of_Units	Henry|H	The SI derived unit of electric inductance. A coil with an inductance of one henry requires a flux of one weber for each ampere of induced current. If it is the current which changes, then the induced field will generate a potential difference within the coil: if the inductance is one henry a current change of one ampere per second generates a potential difference of one volt. The henry is a large unit; inductances in practical circuits are measured in millihenrys or microhenrys.
C42559	Degree_Celsius	Derived_Unit_of_International_System_of_Units|Unit_of_Temperature	Degree Celsius|C|Celsius Degree|Degree Centigrade	A unit of temperature of the temperature scale designed so that the freezing point of water is 0 degrees and the boiling point is 100 degrees at standard atmospheric pressure. The current official definition of the Celsius sets 0.01 C to be at the triple point of water and a degree to be 1/273.16 of the difference in temperature between the triple point of water and absolute zero. One degree Celsius represents the same temperature difference as one Kelvin.
C42560	Lumen	Derived_Unit_of_International_System_of_Units	Lumen|lm	The SI derived unit of luminous flux. It is the amount of light that falls on a unit area at unit distance from a source of one candela.
C42561	Lux	Derived_Unit_of_International_System_of_Units	Lux|lx	The SI derived unit of illuminance equal to the direct illumination on a surface that is everywhere one meter from a uniform point source of one candela; a unit of illuminance that is equal to one lumen per square meter.
C42562	Becquerel	Derived_Unit_of_International_System_of_Units	Becquerel|Bq	The SI derived unit of radioactivity, equal to one nuclear disintegration or other nuclear transformation per second.
C42563	MKS_System	Metric_System	MKS System|MKS	The cluster of metric units based on the centimeter, the gram, and the second as base units.
C42564	CGS_System	Metric_System	CGS System|CGS	CGS system is a clustering of metric units based on the centimeter, the gram, and the second. The ratio between a CGS unit and the corresponding MKS unit is usually a power of 10. The CGS system was introduced formally by the British Association for the Advancement of Science in 1874. Although some of the CGS units remain in use (e.g. by scientists working in small subject contexts) for a variety of purposes, they are being replaced gradually by the SI units selected from the MKS system.
C42565	Gal	Unit_of_Linear_Acceleration	Gal|Galileo	Gal is a non-SI, CGS system unit of gravitational acceleration equal to one centimeter per second per second, named after Galileo.
C42566	Katal	Derived_Unit_of_International_System_of_Units	Katal|kat	The SI unit for measuring catalytic (e.g. enzymatic) activity, the ability of the compound to accelerate the chemical reaction by providing a lower energy pathway between the reactants and the products. One katal is that catalytic activity which will raise the rate of reaction by one mole per second in a specified assay system. When the katal is used, the measurand be specified by reference to the measurement procedure; the measurement procedure must identify the indicator reaction. The katal is not used to express a rate of reaction itself, which should be expressed in moles per second. The katal is too large for most purposes and is usually encountered as the microkatal, nanokatal or picokatal. Non-SI unit called unit (U) defined as micromoles per minute is commonly used, but its definition lacks coherence with the SI system.
C42568	Unit_by_Category	Unit_of_Measure	Unit by Category
C42569	Square_Meter	Derived_Unit_of_International_System_of_Units|Unit_of_Area	Square Meter|Centare|Square Metre|sq. m	The SI unit of area measurement equal to a square whose sides are one meter long. Square meter is equal to 10,000 square centimeters; 0.01 ares; 1.196 square yards; 10.76 square feet; 1550 square inches.
C42570	Cubic_Meter	Derived_Unit_of_International_System_of_Units|Unit_of_Volume	Cubic Meter|Cub. m|Cubic Metre	The SI unit of volume or capacity equal to the volume of a cube with edges one meter in length. It is equal to 1,000 liters; 1,000 cubic decimeters; 10(e+6) cubic centimeters; 25.3 cubic feet; 6.29 barrels.
C42571	Meter_per_Second	Derived_Unit_of_International_System_of_Units|Unit_of_Linear_Velocity	Meter Per Second|Metre Per Second|m/c	Meter per second is the SI derived unit of both speed (scalar) and velocity (vector), defined by distance in meters divided by time in seconds.
C42572	Meter_per_Second_Squared	Derived_Unit_of_International_System_of_Units|Unit_of_Acceleration	Meter Per Second Squared|Meter Per Second Per Second|Metre Per Second Per Second|Metre Per Second Squared|m/c(2)	Meter per second squared is a SI unit of acceleration.
C42573	Reciprocal_Meter	Derived_Unit_of_International_System_of_Units|Unit_of_Wave_Number	Reciprocal Meter|Reciprocal Metre	The SI unit of wave number, the spatial analogue of frequency; closely related to the concept of the wave vector.
C42574	Unit_of_Time	Unit_by_Category	Unit of Time	A measure of duration, a quantity used to specify the order in which events occurred and measure the amount by which one event preceded or followed another.
C42575	Unit_of_Mass_Density	Unit_by_Category	Unit of Mass Density|Unit of Density	An indication of the type of unit of measure being used to express a mass density.
C42576	Kilogram_per_Cubic_Meter	Derived_Unit_of_International_System_of_Units|Unit_of_Mass_Density|Unit_of_Potency	Kilogram Per Cubic Meter|Kilogram Per Cubic Metre	Kilogram per cubic meter is the SI derived unit measure of mass density.
C42577	Cubic_Meter_per_Kilogram	Derived_Unit_of_International_System_of_Units	Cubic Meter Per Kilogram|Cubic Metre Per Kilogram	A SI derived unit of specific volume, a property of materials defined as the number of cubic meters occupied by one kilogram of a particular substance. Specific volume is inversely proportional to density.
C42578	Unit_of_Length	Unit_by_Category	Unit of Length	An indication of the type of unit of measure being used to express a length.
C42579	Unit_of_Mass	Unit_by_Category	Unit of Mass	An indication of the type of unit of measure being used to express a mass.
C42580	Eligibility_Waiver	Document_Type	Eligibility Waiver	An eligibility waiver is an approved exemption to the requirement for a participant to meet eligibility criteria prior to study enrollment.  A sponsor-approved waiver is necessary when a subject fails to meet enrollment criteria, but wishes to be accrued to the trial.
C42581	Precis	Document_Type	Summary|Precis	A shortened version of a speech or written text, containing only the main points.
C42582	Protein_Phosphatase_2A_Complex	Protein_or_Riboprotein_Complex	Protein Phosphatase 2A|PP2A	PP2A core enzyme consists of a 36-kDa catalytic C subunit and a constant 65-kDa regulatory/structural A subunit that interact with either a B regulatory subunit or with cell signaling molecules, that likely modulate substrate selectivity, catalytic activity, and subcellular localization, yielding the trimeric holoenzyme. Combinations of different subunit isoforms can generate many forms of PP2A, which may differ in substrate specificity, subcellular localization, or tissue specific expression.
C42584	Ossified_Mass	Mass	Ossified Mass
C42585	Epithelial_Differentiation	Tissue_Differentiation	Epithelial Differentiation
C42586	Pseudo-Psammoma_Body_Formation	Deposit	Pseudo-Psammoma Body Formation
C42587	Sheet-Like_Growth_Pattern	Morphologic_Architectural_Pattern	Sheet-Like Growth Pattern
C42589	Chondroid_Hamartoma	Hamartoma	Chondroid Hamartoma
C42592	PAK1_Gene	Serine-Threonine_Protein_Kinase_Gene	PAK1 Gene|PAK1|PAK1alpha|p21-Activated Kinase 1 Gene|p21/Cdc42/Rac1-Activated Kinase 1 (STE20 Homolog, Yeast) Gene	The PAK1 gene encodes for p21-Activated Kinase 1 protein, which is one of critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling. Alternative transcripts of this gene have been found, but their full-length natures have not yet been determined.(Gene)
C42593	_11q13-q14	Chromosome_Band	11q13-q14	A chromosome band present on 11q
C42594	p21-Activated_Kinase-1	Serine-Threonine_Protein_Kinase	p21-Activated Kinase 1|AlphaPAK|EC 2.7.1.3|PAK-1	p21-Activated Kinase 1, encoded by the PAK1 gene, shares a high degree of sequence similarity with p21-activated kinase (PAK) family members. PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling and serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology. Alternative transcripts of this gene have been found, but their full-length natures have not yet been determined. (from Gene)
C42596	Sporadic_Retinoblastoma	Retinoblastoma	Sporadic Retinoblastoma
C42597	Epitope_Spreading	Immune_Response	Epitope Spreading	A normal feature of responses to infectious agents that allows recognition of multiple antigenic targets, Epitope Spreading involves non-cross-reactive epitopes, distinct from the inducing epitope, becoming major targets of an ongoing immune response. Epitope spreading (ES) involves an increased presentation of cryptic epitopes (intermolecular ES) or cryptic antigens (intramolecular ES) via MHC II molecules or cross-priming onto MHC I molecules. Subsequently, reactive T-cell and antibody repertoires diversify, resulting in an enhanced overall immune response. Epitope spreading is the primary immunopathogenic event in autoimmune diseases.
C42598	Low_Grade_Appendix_Mucinous_Neoplasm	Appendix_Mucinous_Adenocarcinoma	Appendix Well Differentiated Mucinous Adenocarcinoma|LAMN|Low Grade Appendiceal Mucinous Neoplasm|Low Grade Appendix Mucinous Neoplasm|Low-Grade Appendix Mucinous Neoplasm
C42599	Serrated_Glandular_Architecture	Morphologic_Architectural_Pattern	Serrated Glandular Architecture
C42600	RB-E2F_Pathway_Deregulation	Tumor-Suppressor_Pathway_Deregulation	RB-E2F Pathway Deregulation
C42601	Extraocular_Dissemination_of_Disease	Clinical_Course_of_Disease	Extraocular Dissemination of Disease
C42602	Suprasellar_Region	Body_Region	Suprasellar Region
C42604	Neoplastic_Retinal_Cell	Neoplastic_Cell	Neoplastic Retinal Cell
C42605	Property	Properties_or_Attributes	Property	A basic or essential attribute shared by all members of a class.
C42606	Chemotherapeutic_Agent_Toxicity	Drug_Toxicity|Therapy-Related_Toxicity	Chemotherapeutic Agent Toxicity
C42607	Therapy-Related_Toxicity	Toxicity	Therapy-Related Toxicity
C42608	Computer_Application	Computer_Program	Computer Application|Application	A program that gives a computer instructions that provide the user with tools to accomplish a task.
C42609	Ancestor	Relative	Ancestor|Ancestors	Someone from whom you are descended (but usually more remote than a grandparent).
C42610	Abbreviation	Terminology_Entity	Abbreviation	A shortened form of a word or phrase.
C42612	Active_Flag	Flag	Active Flag	An indication of whether the item in question is an active item.
C42613	Administered_Component	UML_Entity	Administered Item|Administered Component	A registry item for which administrative information is recorded in an Administration Record. (ISO 11179)
C42614	Name_Generic_Concept	Conceptual_Entities	Name	The words or language units by which a thing is known.
C42615	Approved_By	General_Modifier	Approved By	Indicates the person or authoritative body who has given approval.
C42616	Protection_Element_Attribute	UML_Entity	Protection Element Attribute|Attribute	It is the attribute of the object which is to be protected. It along with the object id forms the unique key which can identify the protection element.
C42617	Authentication_Policy_Configuration_Name	UML_Entity	Authentication Policy Configuration Name	This name represents the name that should be used to get all the configuration for authentication for this application.
C42618	GSK3A_Gene	Serine-Threonine_Protein_Kinase_Gene	GSK3A Gene|GSK3-alpha|GSK3A|Glycogen Synthase Kinase 3 Alpha Gene	Glycogen synthase kinase 3-alpha gene product is a multifunctional protein and is implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN (By similarity).
C42619	Note	Document_Type	Note	A brief written record.
C42620	Created	General_Modifier	Created	Brought into existence.
C42621	Glycogen_Synthase_Kinase_3_Alpha	Serine-Threonine_Protein_Kinase	Glycogen Synthase Kinase 3 Alpha|EC 2.7.1.37|GSK3-alpha|GSK3A	This protein belongs to the Ser/Thr protein kinase family, CDC2/CDKX subfamily; GSK-3 subsubfamily and is implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN (By similarity).GSK3alpha is a potential regulator of platelet function.(from OMIM, Gene)
C42624	Premalignant_Lesion	Lesion_by_Morphology	Premalignant Lesion
C42625	RASGRF1_Gene	Signaling_Pathway_Gene	RASGRF1 Gene|CDC25|GNRP|GRF55|RAS-GRF1|RASGRF1|Ras Protein-Specific Guanine Nucleotide-Releasing Factor 1 Gene|Ras-Specific Nucleotide Exchange Factor CDC25	This gene belongs to the family of RAS Guanine-nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) which stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. (from Gene)
C42627	Ras_Protein_Specific_Guanine_Nucleotide_Releasing_Factor_1	Guanine_Nucleotide_Exchange_Factor	Ras Protein Specific Guanine Nucleotide Releasing Factor 1|CDC25|GNRP|GRF1|GRF55|Guanine Nucleotide-Releasing Factor, 55KD|H-GRF55|RASGRF1|Ras-specific nucleotide exchange factor|Ras-specific nucleotide exchange factor CDC25	The protein is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested, that the Ras-GEF activity of this protein in brain, can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.(from Gene)
C42628	Created_By	General_Modifier	Created By	Indicates the person or authoritative body who brought the item into existence.
C42629	Modified_By	General_Modifier	Modified By	Indicates the person or authoritative body who changed an item.
C42630	Attribute_Set_Descriptor	UML_Entity	Attribute Set Descriptor
C42631	Character_Set	Document_Type	Character Set	A defined list of characters recognized by the computer hardware and software. Each character is represented by a number.
C42632	Classification_Scheme_Item_Relationship	UML_Entity	Classification Scheme Item Relationship	The affiliation between two occurrences of Classification Scheme Items.
C42633	Classification_Scheme_Relationship	UML_Entity	Classification Scheme Relationship	The affiliation between two occurrences of Classification Schemes.
C42634	Dental_Material	Biomaterials	Dental Material	Material or substance used in dentistry, both inorganic and organic. The term refers particularly, to thermoplastic and thermosetting resins, poly-siloxanes, polymers associated with restorative materials; ionic polymers, silicones, polymethylmethacrylate, BIS-GMA, reinforced polymers, composites, metals, cements, dental porcelains, etc.
C42635	Cement	Dental_Material	Cement Material|Cement
C42636	Pharmaceutical_Dosage_Form	Diagnostic_Therapeutic_and_Research_Equipment	Pharmaceutical Dosage Form|Drug Dosage Form|Drug Dosage Forms|PHARMACEUTICAL DOSAGE FORM|Pharmaceutical Agent Dosage Form|Pharmaceutical Agent Dosage Forms|Pharmaceutical Dosage Forms|Pharmaceutical Dose Form	The form of the completed pharmaceutical product, e.g. tablet, capsule, injection, elixir, suppository. Dosage form can have a significant effect on the onset, duration and intensity of the pharmacological action of a drug. A pharmaceutical dosage form controls the rate at which the drug is released into the biological fluids. This release rate affects its intrinsic absorption pattern and therefore, the bioavailability of the drug.
C42637	Pharmaceutical_Excipient	Industrial_Aid	Pharmaceutical Excipient|Drug Excipient|Excipient|Pharmaceutical Excipients
C42638	Pharmaceutical_Formulation	Pharmaceutical_Product_Characteristics	Pharmaceutical Formulation|Drug Formulation	The composition of a dosage form, including the characteristics of its raw materials and the operations required to process it.Formulation factors include chemical nature of the drug (ester, salt, complex, etc), drug solubility in water and organic solvents, particle size and surface area, type of dosage form (solution, suspension, capsule, tablet) and the excipients and processes used in the manufacturing of the drug delivery systems. The design of optimal drug delivery systems is thus an important part of providing an effective therapeutic.Official formulations for approved agents are presented in such books as the National Formulary and US Pharmacopeia. Whereas at one time, these were detailed and almost recipe-like, more recent entries may be limited to specifying the formula and imposing a standard limit for the active agent.
C42639	Finished_Pharmaceutical_Product	Drugs_and_Chemicals_Functional_Classification	Finished Pharmaceutical Product	A pharmaceutical product that has undergone all stages of production and testing, including packaging in its final container and labelling.
C42640	Component_Concept	UML_Entity	Component Concept	The concept component(s) used for a concept derivation.
C42641	Concatenation_Character	UML_Entity	Concatenation Character	The symbol used to represent a linking of separate elements.
C42642	Administered_Component_Concept	UML_Entity	Administered Component Concept|Concept	The concept for an administered component.
C42643	Concept_Derivation_Rule	Retired_Concepts	Concept Derivation Rule	The derivation rule between one or more concepts.
C42644	Data_Element_Relationship	UML_Entity	Data Element Relationship|Data Element Relationships	The affiliation between two occurrences of Data Elements.
C42645	Data_Type	Conceptual_Entities	Data Type	An indication of the form that a value will have.  Examples include string, integer, and character.
C42646	Decimal_Place	Conceptual_Entities	Decimal Place	An indication of the specific number of digits to be expected to the right of the decimal point in a line of numbers.
C42647	Binder_Excipient	Pharmaceutical_Excipient	Binder Excipient|Binder	An inactive ingredient of the solid pharmaceutical dosage form added to cement the active and inert components of tablets together to maintain cohesive and discrete portions. These are especially important in the production of time-release products. Binders provide the matrix from which the drug is gradually secreted.Binding agents which have adhesive properties are important excipients, especially for lozenges and tablets. The choice of the particular binder or thickening agent is dependent upon the desired properties of adhesive strength and thickness. Thus, one would be a better agent for a lozenge when slow dissolution in the mouth is desirable whereas another would provide more rapid disintegration for other purposes. The commonly used binder excipients in U.S.-manufactured drug products are microcrystalline cellulose and starch.
C42648	Disintegrant_Excipient	Pharmaceutical_Excipient	Disintegrant Excipient|Disintegrant	Disintegrant excipient is a therapeutically inactive ingredient of a solid pharmaceutical dosage form that helps the form to dissolve within the gastrointestinal tract to ensure full release of the pharmaceutically active material. Disintegration rate of the tablet may be the rate limiting step for the absorption of the drug. Currently, disintegrants have been developed to the point that disintegration is not usually the rate limiting step. The US Pharmacopeia sets a time limit for disintegration. Microcrystalline cellulose and starch are examples of disintegrants.
C42649	Declarative_Flag	Flag	Declarative Flag	An indication of whether an application uses declarative security.
C42650	Filler_Excipient	Pharmaceutical_Excipient	Filler Excipient|Filler	A therapeutically inactive ingredient of a solid pharmaceutical dosage form that is used to increase the volume of the material to accommodate easier processing of the drug and to make it a suitable size for patient consumption Typical fillers include calcium phosphate (also an added source of both minerals), lactose, powder, sucrose powder.
C42651	Protocol_Generic_Term	Document_Type	Protocol	A rule which guides how an activity should be performed.
C42652	Diluent_Excipient	Pharmaceutical_Excipient	Diluent Excipient|Diluent	A therapeutically inactive ingredient of a fluid pharmaceutical dosage form that is used to increase the volume of the material to accommodate easier processing of the drug (especially accurate dilutions) and to make it a suitable size for patient consumption.
C42653	Lubricant_Excipient	Pharmaceutical_Excipient	Lubricant Excipient|Lubricant	Lubricant excipient is a therapeutically inactive substance used to facilitate the release of stamped solid pharmaceutical dosage forms, e.g. tablets, out of the die once pressed, improving the efficiency of manufacturing. Magnesium stearate is an example.
C42654	Glidant_Excipient	Pharmaceutical_Excipient	Glidant Excipient|Glidant	An inactive ingredient of the solid pharmaceutical dosage form added to cement the active and inert components of tablets together to maintain cohesive and discrete portions. These are especially important in the production of time-release products. Binders provide the matrix from which the drug is gradually secreted. The commonly used binder excipients in U.S.-manufactured drug products are microcrystalline cellulose and starch.
C42655	Compression_Aid_Excipient	Pharmaceutical_Excipient	Compression Aid Excipient|Compression Aid	Therapeutically inactive substance that helps to make pills hold their shape upon compression and improve compressibility properties in general.
C42656	Color_Excipient	Pharmaceutical_Excipient	Color Excipient|Color|Coloring Excipient	Therapeutically inactive dye or coloring agent that is a component of pharmaceutical product. There are the more than 100 excipient colors approved by the FDA for pharmaceutical use.
C42657	Printing_Ink_Excipient	Pharmaceutical_Excipient	Printing Ink Excipient|Drug Printing Ink|Printing Ink	An inactive ingredient of the solid pharmaceutical dosage form added to cement the active and inert components of tablets together to maintain cohesive and discrete portions. These are especially important in the production of time-release products. Binders provide the matrix from which the drug is gradually secreted. The commonly used binder excipients in U.S.-manufactured drug products are microcrystalline cellulose and starch.
C42658	Sweetener_Excipient	Pharmaceutical_Excipient	Sweetener Excipient|Drug Sweetener|Sweetener	Therapeutically inactive ingredient of pharmaceutical dosage form used to improve taste of a drug. Aspartame, fructose, saccharin, sorbitol, and sucrose are the most commonly used sweeteners in the United States.
C42659	Preservative_Excipient	Pharmaceutical_Excipient	Preservative Excipient|Drug Preservative|Preservative	Chemicals that are added to drug products to prolong shelf life and maintain sterility. Protection of formulations, especially aqueous solutions, against microbial growth requires use of either antibacterial or antifungal preservatives. Generally, such agents are active against either bacteria or fungi but a few are active against both. The antimicrobials include but not limited to chlorobutanol, benzyl alcohol, sodium benzoate, sorbic acid, and phenol. The antioxidizing agents include butylated hydroxytolune, hydroxyanisole, propyl gallate, and sulfites. The necessary addition of preservatives for both safety and economy sometimes has been associated with significant adverse effects in certain patient populations.
C42660	Suspending_Excipient	Pharmaceutical_Excipient	Suspending Excipient|Drug Suspending Agent|Suspending|Suspending Agent|Suspensing Excipient	Therapeutically inactive ingredient of pharmaceutical dosage form used to prevent aggregation of the active drug in liquid form, allowing uniform concentrations to be maintained for accurate dosing.
C42661	Definition_Class_Scheme_Item	UML_Entity	Definition Class Scheme Item	A class that serves to allow many to many relationships between Definitions and ClassSchemeClassSchemeItem, providing uniqueness to the CS/CSI pairing to a definition.
C42662	Dispersing_Excipient	Pharmaceutical_Excipient	Dispersing Excipient|Dispersing|Drug Dispersing Agent	An inactive ingredient of the solid pharmaceutical dosage form added to cement the active and inert components of tablets together to maintain cohesive and discrete portions. These are especially important in the production of time-release products. Binders provide the matrix from which the drug is gradually secreted. The commonly used binder excipients in U.S.-manufactured drug products are microcrystalline cellulose and starch.
C42663	Coating_Excipient	Pharmaceutical_Excipient	Coating Excipient|Coating	Therapeutically inactive ingredient of pharmaceutical dosage form used to protect it against premature physical breakup and to prevent unwanted environmental interactions. Coating can mask bad taste and allow pills to be swallowed easily. Several types of coatings are used: thin film, sugar coating, enteric coating (the most unpredictable because such coated tablets may pass through the stomach intact and be released into the intestine at unpredictable intervals all at one time rather than slowly over a period of time. Typical pill coatings include zein, shellac, or sugars.
C42664	Flavor_Excipient	Pharmaceutical_Excipient	Flavor Excipient|Drug Flavoring Agent|Flavor|Flavoring Excipient	Therapeutically inactive natural or synthetic ingredient(s) of pharmaceutical dosage form used to improve drug palatability. Flavors are often complex mixtures of compounds and often fall under the rubric of trade secrets, being unspecified on labels. Such nondisclosure can cause difficulties in identifying flavor-related adverse events, e.g. allergic reactions from common allergens such as menthol, lemon oil, or peppermint oil.
C42665	Essential_Minor_Component_of_Pharmaceutical_Excipient	Pharmaceutical_Excipient	Essential Minor Component of Pharmaceutical Excipient|Essential Minor Component of Drug Excipient|Essential Minor Component of Excipient	Any material present in a pharmaceutical excipient that is not the main chemical component or components, and is necessary for the excipients proper performance during use.
C42666	Pharmaceutical_Product-related_Substance	Pharmacologic_Substance	Pharmaceutical Product-related Substance	Molecular variants of the desired biological product formed during manufacture and/or storage, which are active and have no deleterious effect on the safety and efficacy of the drug substance or drug product. These variants possess properties comparable to the desired product and are not considered impurities.
C42667	Pharmaceutical_Product_Information	Document_Type	Pharmaceutical Product Information	A document defining content and form of the information that has to be supplied with or about a pharmaceutical product by or on behalf of the marketing authorization holder. The minimum information in the product information is that defined by WHOs sample product information sheet. In international setting according to WHOs requirements, the content of the product information is agreed between the marketing authorization holder and the drug authorization authorities at the time the market authorization is issued.
C42668	Master_Formula_of_Pharmaceutical_Product	Pharmaceutical_Product_Information	Master Formula of Pharmaceutical Product	A document or set of documents specifying the starting materials with their quantities and the packaging materials, together with a description of the procedures and precautions required to produce a specified quantity of a finished pharmaceutical product as well as the processing instructions, including in-process controls.
C42669	Immediate_Release_Dosage_Form	Drug_Release_Formulation	Immediate Release Dosage Form|Conventional Release Dosage Form|Immediate Release Dose Form	A pharmaceutical dosage form that is intended to release all its active ingredient(s) on administration with no enhanced, delayed or extended release effect.
C42670	Deleted_Indicator	UML_Entity	Deleted Indicator
C42671	Department_Name	UML_Entity	Department	A specialized division of a large organization.
C42672	Sustained-release_Dosage_Form	Modified-Release_Dosage_Form	Sustained-release Dosage Form|Sustained-release Dose Form
C42673	Definition_Source	Retired_Concepts	Definition Source	The person or authoritative body who provided the definition.
C42674	Descendent	Relative	Descendent|Descendents	Someone deriving or descending from an ancestor.
C42675	Designation_Class_Scheme_Item	UML_Entity	Designation Class Scheme Item	A class that serves to allow many to many relationships between Designation and ClassSchemeClassSchemeItem, providing uniqueness to the CS/CSI pairing to an Designation.
C42676	Dimensionality	Characteristics	Dimensionality	The state of having dimensions; an indication of the dimensions associated with an object.
C42677	Direction	Conceptual_Entities	Direction	The spatial relation between something and the course along which it points or moves.
C42678	Cigarette_Dosage_Form	Solid_Dosage_Form	Cigarette Dosage Form|CIGARETTE|Cigarette Dose Form	A narrow tube filled with material that is capable to burn with release of therapeutically-active substance(s) during the process of smoking. Cigarette is a very efficient drug-delivery inhaler system for fast-acting substances.
C42679	Douche_Dosage_Form	Solution_Dosage_Form	Douche Dosage Form|DOUCHE|Douche Dose Form	A liquid preparation, intended for the irrigative cleansing of the vagina, that is prepared from powders, liquid solutions, or liquid concentrates and contains one or more chemical substances dissolved in a suitable solvent or mutually miscible solvents.
C42680	Order	Properties_or_Attributes	Order	A logical or comprehensible arrangement of separate elements.
C42682	Edit_Action	Conceptual_Entities	Edit Action	The type of change made to an element.
C42684	User_Group	Population_Group	User Group|Group	A user group is a set of people who have similar interests, goals, or concerns.
C42685	Group_Object	UML_Entity	Group Object|Group	The group object of the group which assumes the roles in context of a protection group.
C42686	Group_Role_Context	UML_Entity	Group Role Context	It is the class which hold the roles which are assumed by a particular group in the context of a protection group.
C42687	EVS_Concept_Object_History	UML_Entity	EVS Concept Object History|History	This class encapsulates the history of an EVS concept object.
C42688	Instruction	Document_Type	Instruction	A message describing how something is to be done.
C42689	Spinal_Disk_Implant	Implant	Spinal Disk Implant	An interbody spinal implant of flat circular form for insertion at least in part across a disc space between adjacent vertebral bodies of a human spine as a part of surgical solution for degenerative disk disease or another morbid condition, which causes serious vertebral disk structure damage.
C42690	Lip_and_Oral_Cavity_Squamous_Cell_Carcinoma	Head_and_Neck_Squamous_Cell_Carcinoma|Lip_and_Oral_Cavity_Carcinoma	Lip and Oral Cavity Squamous Cell Carcinoma
C42691	Large_Element_Count_Flag	Flag	Large Element Count Flag	A flag indicating whether the protection group has a large number of protection elements.
C42692	Latest_Version_Indicator	Retired_Concepts	Latest Version Indicator|latestVersionIndicator
C42693	Pharmaceutical_Product_Expiration_Date	Pharmaceutical_Product_Characteristics	Pharmaceutical Product Expiration Date	A date, determined by stability tests for pharmaceutical agent batch, lot, etc., after which the product may not meet the appropriate regulatory agencies requirements. Expiration dates are generally limited to no more than 3 years after production, but longer stability periods are allowed for some very stable materials.
C42694	Login_Name	UML_Entity	Login Name|Account Name|User ID|User Name	The account name used by a person to access a computer system.
C42695	Meta_Thesaurus_Concept	UML_Entity	Meta Thesaurus Concept	This class encapsulates the attributes of EVS MetaThesaurus Concept object.
C42696	Maximum_Length_Number	UML_Entity	Maximum Length Number	Indicates the greatest number of characters permissible in a value.
C42697	Minimum_Length_Number	UML_Entity	Minimum Length Number	Indicates the least number of characters permissible in a value.
C42698	Terminology_Entity	NCI_Administrative_Concepts	Terminology Entity	Terminology entities represent the elements that form and define an ontology.
C42699	Namespace_Entity	Terminology_Entity	Namespace|Namespace Entity	In general, a namespace is an abstract container, which is or could be filled by names, or technical terms, or words, and these represent or stand for real-world things.  A description logic terminology namespace is a collection of Kind, Role, Property and Concept definitions. As in computer programming, context namespaces are intended to allow multiple knowledge bases to reside in the same physical database. (from Wikipedia and Apelon)
C42700	Uterine_Carcinosarcoma	Malignant_Mixed_Mesodermal_Mullerian_Tumor|Malignant_Uterine_Neoplasm	Uterine Carcinosarcoma|Carcinosarcoma of the Uterus|Malignant Mixed Mesodermal (Mullerian) Tumor of the Uterus|Uterine Malignant Mixed Mesodermal (Mullerian) Tumor
C42702	Object_Class_Relationship	UML_Entity	Object Class Relationship	A description of the affiliation between two occurrences of Object Classes.
C42703	Origin	Conceptual_Entities	Origin	The place where something begins or comes from in either the sense of a physical location or a metaphysical source.
C42704	Owner	Person	Owner	One with an interest in, dominion of, or control over an object or property.
C42705	Drug_Release_Formulation	Pharmaceutical_Dosage_Form	Drug Release Formulation	Classification of dosage forms according to the characteristics of drug release.
C42706	Protection_Group	UML_Entity	Protection Group	This class represents a Protection Group. It is nothing but a collection of protection elements. A user or a user-group can assume various roles on a protection group.
C42708	Child_Offspring	Relative	Child|Children|Human, Child|Offspring|progeny	A human offspring (son or daughter) of any age.
C42709	Parent	Relative	Parent|Parental	A mother or a father; an immediate progenitor.
C42710	Password	Conceptual_Entities	Password	A secret set of characters, numbers, or symbols used as a form of authentication.
C42711	Preferred	General_Modifier	Preferred	Designated as more desirable.
C42712	Modified-Release_Dosage_Form	Drug_Release_Formulation	Modified-Release Dosage Form|Modified-Release Dose Form	A term used to describe pharmaceutical products that have a reduced rate of release of active substance including extended-release, prolonged-release, controlled-release, controlled-delivery, slow-release and sustained-release dosage forms.
C42713	Extended-Release_Dosage_Form	Modified-Release_Dosage_Form	Extended-Release Dosage Form|Extended-Release Dose Form|Prolonged-Release Dosage Form	Extended release dosage form is a modified pharmaceutical form of which the release of the active substance and its subsequent absorption are prolonged in comparison with a conventional non-modified form. The prolonged release of the active substance in man produces a spread of blood/plasma concentration as a function of time, with an increased apparent elimination half-life and/or reduction in peaks or achievement of a plateau. The staggering of concentrations is accompanied by a prolongation of therapeutic action without any increase, and possibly with and possibly with a reduction of probability of adverse events.
C42716	Bone_Marrow_Myeloid_Stem_Cell_with_Potential_to_Differentiate_to_Granulocytic_Lineage	Myeloid_Progenitor_Cell	Bone Marrow Stem Cell with Potential to Differentiate to Granulocytic Lineage	A primitive, undifferentiated blood cell which can undergo division and give rise to white blood cells in the neutrophil, eosinophil or basophil lines.
C42717	Description_Logic_Concept	UML_Entity	Description Logic Concept|Desc Logic Concept	This class encapsulates the attributes of EVS DescLogicConcept object.
C42718	Concept_Unique_Identifier	Identifier|Terminology_Entity	Concept Unique Identifier|CUI|NLM CUI|UMLS CUI	In the Unified Medical Language System (UMLS) of the National Library of Medicine (NLM) the concept unique identifier (CUI) is an 8-character identifier beginning with the letter "C" and followed by 7 digits.  Each concept is assigned such a CUI.  The CUI has no intrinsic meaning but remains constant through time and across versions.
C42719	Cells_of_Monocytic_Lineage_80_Percent_or_More_of_Bone_Marrow_Leukemic_Cells	Immature_Myeloid_Cells_Increased_in_Bone_Marrow	Cells of Monocytic Lineage 80 Percent or More of Bone Marrow Leukemic Cells
C42720	Ras_Protein_Specific_Guanine_Nucleotide_Releasing_Factor_2	Guanine_Nucleotide_Exchange_Factor	Ras Protein Specific Guanine Nucleotide Releasing Factor 2|GRF2|RASGRF2|Ras-specific nucleotide exchange factor	Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form. RASGRF2 is able to activate both RAS and RAC, thereby coordinating the signaling of distinct MAP kinase cascades.(from OMIM, Gene)
C42721	Module	UML_Entity	Module	A self-contained component (unit or item) that is used in combination with other components.
C42722	User_Privilege	UML_Entity	User Privilege|Privilege	The operations and access levels which are allowed to a user (e.g Create, Read, Update, Delete).
C42723	Role_Privilege	UML_Entity	Role Privilege|Privilege|Privileges	A collection of Privilege objects. Indicates which privileges belong to this role.
C42724	Protection_Element	UML_Entity	Protection Element	A Protection Element is any resource that is protected. This way the access to different part of the data can be restricted.
C42725	Protection_Group_Role_Context	UML_Entity	Protection Group Role Context	This class establishes the relationship between protection group and roles and becomes a member for a user and a group.
C42726	Neoplastic_Granulocytes_and_Precursors_20_Percent_or_More_of_Bone_Marrow_Cells	Granulocytes_Increased_in_Bone_Marrow	Neoplastic Granulocytes and Precursors 20 Percent or More of Bone Marrow Cells
C42727	Concept_Relationship	Terminology_Entity	Concept Relationship|Relationship|rel|rela	Any of the relationships between concepts. The vertical, hierarchical relationships may be referred to as Parent, Child, Broader, Narrower, isa, inverse-isa, Super Concept, Subconcept, etc.  The horizontal named relationships include Roles and Associations.
C42728	Reviewed_By	General_Modifier	Reviewed By	Indicates the person or authoritative body who appraised, evaluated, or analyzed the item.
C42729	Review	Clinical_or_Research_Activity	Review	The act of appraisal, evaluation, or analysis.
C42730	Delayed-Release_Dosage_Form	Modified-Release_Dosage_Form	Delayed-Release Dosage Form|Delayed-Release Dose Form	Pharmaceutical formulation that involves the release of discrete amount(s) of drug some time after drug administration, e.g. enteric-coated products, and exhibit a lag time during which little or no absorption occurs.
C42731	Controlled-Release_Dosage_Form	Modified-Release_Dosage_Form	Controlled-Release Dosage Form|Controlled-Release Dose Form	A dosage form designed to release medication over extended time periods to avoid high concentrations in the digestive tract or to provide longer duration of action than are available through conventional dosage forms. Controlled release system is able to provide some actual therapeutic control, whether of a temporal nature, spatial nature, or both.
C42732	Semantic_Type_Property	NCI_Thesaurus_Property	Semantic Type	The semantic type describes the sort of thing or category to which a concept belongs in the context of the UMLS semantic network.
C42733	Protein_Kinase_C_Beta_1	Protein_Kinase-C	Protein Kinase C-Beta 1|PKCB|PRKCB1|Protein Kinase C Beta,polypeptide 1	Protein Kinase C-beta is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. May be considered as a novel component of the NF-kappa-B signaling axis responsible for the survival and activation of B cells after BCR cross-linking (By similarity). Phosphorylation on Thr-500 of isoform beta-I, within the activation loop, renders it competent to autophosphorylate. Subsequent autophosphorylation of Thr-642 maintains catalytic competence, and autophosphorylation on Ser-661 appears to release the kinase into the cytosol.(NCI)
C42734	Contraceptive_Device	Medical_Device	Contraceptive Device	A device designed to prevent conception through local or systemic effect, such as a barrier contraceptive, an intrauterine device, or a means of preventing ovulation (e.g., birth control pill).
C42735	Serial_Version_Unique_Identifier	Identifier	Serial Version Unique Identifier|Serial Version UID	Maintains a reference (via a proxy to the EVSManager).
C42736	Polymeric_Microsphere_Dosage_Form	Controlled-Release_Dosage_Form	Polymeric Microsphere Dosage Form|Polymeric Microsphere Dose Form	A controlled release formulation in which the drug is incorporated into polymeric microspheres consisting of biocompatible polymer The reconstituted microspheres are injected usually intramuscularly and erode slowly in vivo, releasing the drug. Some microsphere polymers can enhance the efficacy of adjuvants in sustained- and controlled-release systems.
C42737	Term_Type_Property	Terminology_Entity	Term Type|Term Group|Term Type Property|Termgroup	An indicator of a particular "meaning" of a term.  In the NCI Thesaurus the most term types common are 'Preferred Term' (PT) and 'Synonym' (SY).  The term type resides in the second subfield of the NCI FULL_SYN property.
C42738	Biopharmaceutics	Pharmacology	Biopharmaceutics	The study of the physical and chemical properties of a drug and its dosage forms and study of the influence of formulation factors of the agent on the therapeutic activity of a drug product.
C42739	Surfactant_Excipient	Pharmaceutical_Excipient	Surfactant Excipient|Surface Active Excipient	A surface active agent (surfactant), in dilute solution, moves to the interface of a two-phase system and reduces the surface free energy. This permits the two phases to mix more completely. Surface active agents are usually soluble both in aqueous and non-aqueous solvents. They are exemplified by soap-type molecules (long chain fatty acid salts) such as sodium lauryl sulfate.
C42740	Diffusion-Controlled_Extended-Release_Dosage_Form	Extended-Release_Dosage_Form	Diffusion-Controlled Extended-Release Dosage Form|Diffusion-Controlled Extended-Release Dose Form	A dosage form with a water-insoluble polymer which controls the flow of water and the subsequent egress of dissolved drug. Both diffusional and dissolution processes are involved. In reservoir devices, a core of drug is coated with the polymer and, in matrix systems, the drug is dispensed throughout the matrix. Cellulose derivatives are commonly used in the reservoir types, while the matrix material may be plastics, e.g. methylacrylate-methyl methacrylate, polyvinyl chloride, hydrophilic polymers such as cellulose derivatives or fatty compounds including carnauba wax.
C42741	Dissolution-Controlled_Extended-Release_Dosage_Form	Extended-Release_Dosage_Form	Dissolution-Controlled Extended-Release Dosage Form|Dissolution-Controlled Extended-Release Dose Form	A dosage form with the rate of dissolution of the drug (and thereby bioavailability) controlled by slowly soluble polymers or by microencapsulation. Once the coating is dissolved, the drug becomes available for dissolution. By varying the thicknesses of the coat and its composition, the rate of drug release can be controlled. Some preparations contain a fraction of the total dose as an immediate-release component to provide a pulse dose soon after administration. The pellet dosage forms of diffusion- or dissolution-controlled products can be encapsulated or prepared as a tablet.
C42742	Erosion-Controlled_Extended-Release_Dosage_Form	Extended-Release_Dosage_Form	Erosion-Controlled Extended-Release Dosage Form|Erosion-Controlled Extended-Release Dose Form	A dosage form with the release of drug controlled by the erosion rate of a carrier matrix. The rate of release is determined by the rate of erosion.
C42743	Uniform_Resource_Locator	Uniform_Resource_Identifier	Uniform Resource Locator|URL	An Internet address which tells a browser where to find an Internet resource. (from http://www.computeruser.com)
C42744	Oral_Dosage_Form	Dosage_Form_By_Route_Of_Administration	Oral Dosage Form|Oral Dose Form	Different formulations for oral administration include solutions, suspensions, capsules, compressed tablets, coated medications and controlled release dosage forms. The availability of a drug for absorption is maximal in solutions and decreases in descending order with suspensions, capsules, compressed tablets, and coated tablets, respectively.
C42745	User	Person	User|Users	An individual who uses a computer, program, network, or related service for work or entertainment. (from http://www.computeruser.com/resources/dictionary/index.html)
C42746	Parenteral_Dosage_Form	Dosage_Form_By_Route_Of_Administration	Parenteral Dosage Form|Parenteral Dose Form	A dosage form designed for administration not through the alimentary canal but rather by injection through some other route, such as subcutaneous, intramuscular, intraorbital, intracapsular, intraspinal, intrasternal, or intravenous. Formulations for parenteral administration include solutions, emulsions, suspensions, lyophilized formulations and sustained-release dosage forms. Common excipients used in parenteral formulations include: solvents and co-solvents; solubilizing, wetting, suspending, emulsifying or thickening agents; chelating agents; antioxidants and reducing agents; antimicrobial preservatives; buffers and pH adjusting agents and bulking agent, protectants and tonicity adjusters.
C42747	Topical_Dosage_Form	Dosage_Form_By_Route_Of_Administration	Topical Dosage Form|Dosage Form For Local Administration|Topical Dose Form	A dosage form designed for the local administration a particular surface area, and affecting only the area to which it is applied.
C42748	Value_Domain	UML_Entity	Value Domain	A set of permissible values for a data element.
C42749	Value_Domain_Concept	UML_Entity	Value Domain Concept	Concepts for a Value Domain.
C42750	Value_Domain_Relationship	UML_Entity	Value Domain Relationship	The affiliation between two occurrences of Value Domains.
C42751	Sublingual_Tablet	Oral_Tablet_Dosage_Form	Sublingual Tablet Dosage Form|Sublingual Tablet Dose Form	A sublingual tablet can offer many of the benefits of a non-oral route without the unpleasant effects of a troche. Dissolving the tablet under the tongue introduces drug directly into the blood stream while by passing the metabolism that may occur in the liver. By delivering substance directly into the circulation, problems with bio-availability due to the digestive tract might also be avoided, and often a lower dose can be used effectively. Generally there may be a 5-7% increase in absorption when using a sublingual tablet in comparison with a standard oral dosage form.
C42752	Hypodermic_Tablet	Tablet_Dosage_Form	Hypodermic Tablet Dosage Form|Hypodermic Tablet Dose Form	A tablet containing a medicinal substance to be dissolved in solvent for hypodermic (subcutaneous, intracutaneous, intramuscular, or intravenous) injection by means of a hypodermic syringe and needle.
C42753	Workflow	Conceptual_Entities	Workflow	Workflow is the operational aspect of a work procedure: how tasks are structured, who performs them, what their relative order is, how they are synchronized, how information flows to support the tasks and how tasks are being tracked. (from Wikipedia)
C42754	Role_Entity	Terminology_Entity	Role Entity|Role|Terminology Role	A non-hierarchical, named relationship between concepts.  They are binary relationships pointing from one concept to another concept.  Roles are unidirectional and each role has a Domain and a Range; the role points from one kind, the domain, to another (or same) kind, the range.  The specific concept pointed to is considered the Role Value.
C42755	Buccal_Tablet	Tablet_Dosage_Form	Buccal Tablet Dosage Form|Buccal Tablet Dose Form	A small flat tablet to be administered by placing it between the cheek and gum, permitting the direct absorption through the oral mucosa of the medicinal substance contained therein.
C42756	Dispensing_Tablet	Tablet_Dosage_Form	Dispensing Tablet Dosage Form|Dispensing Tablet Dose Form	A compressed or molded tablet containing a large quantity of a drug, usually used by dispensing pharmacists in compounding prescriptions.
C42757	NCI_Concept_Atom	Terminology_Entity	NCI Concept Atom|Atom|Concept Atom	In the NCI Thesaurus an atom consists of a term string, a term type, a term source, and an optional term code.  They can be thought of as synonyms or alternative valid forms of a particular concept. This information resides in the property FULL_SYN.
C42758	Enteric-Coated_Tablet	Coated_Tablet_Dosage_Form	Enteric-Coated Tablet Dosage Form|Enteric-Coated Tablet Dose Form	A tablet coated with material that delays release of the medication until after it leaves the stomach.
C42759	Tablet_Triturate	Solid_Dosage_Form	Tablet Triturate Dosage Form|Tablet Triturate Dose Form	A small, usually cylindrical compressed tablet containing medicated powder dispersed with a mixture of lactose and powdered sucrose, in varying proportions, with a moistening agent.
C42760	Osmotic_Pump_Extended-Release_Dosage_Form	Extended-Release_Dosage_Form	Osmotic Pump Extended-Release Dosage Form|Osmotic Pump Extended-Release Dose Form	A dosage form with the release of drug determined by the constant inflow of water across a semipermeable membrane into a reservoir which contains an osmotic agent. The drug is either mixed with the agent or is located in a reservoir. The dosage form contains a small hole from which dissolved drug is pumped at a rate determined by the rate of entrance of water due to osmotic pressure. The rate of release is constant and can be controlled within tight limits yielding relatively constant blood concentrations. The advantage of this type of product is that the constant release is unaltered by the environment of the gastrointestinal tract and relies simply on the passage of water into the dosage form. The rate of release can be modified by altering the osmotic agent and the size of the hole.
C42761	Format	Properties_or_Attributes	Format	The organization of information according to preset specifications.
C42762	Abnormal_Eosinophilic_Granules_Present	Morphologic_Finding	Abnormal Eosinophilic Granules Present
C42763	Dressing_Dosage_Form	Solid_Dosage_Form	Dressing Dosage Form|DRESSING|Dressing Dose Form	A dosage form designed for local administration, usually placed on a pad that will cover an affected area. This dosing form is used in order to support the natural healing process, protect granulation tissue and nerve endings and to reduce the risk of secondary infection.
C42764	Living_Culture	Research_Techniques	Living Culture
C42765	Tree_Node	Terminology_Entity	Tree Node|Node	A term that refers to any individual item or entity in a hierarchy or pedigree.
C42766	Bone_Marrow_Myeloid_Stem_Cell_with_Potential_to_Differentiate_to_Granulocytic_and_Monocytic_Lineages	Myeloid_Progenitor_Cell	Bone Marrow Stem Cell with Potential to Differentiate to Granulocytic and Monocytic Lineages	A primitive, undifferentiated blood cell which can undergo division and give rise to white blood cells in the neutrophil, eosinophil, basophil or monocyte lines.
C42767	Vaginal_Diaphragm	Contraceptive_Device	Vaginal Diaphragm	A medical contraceptive device of soft flexible material, usually of thin rubber, that is designed to cover the cervix uteri prior to sexual intercourse to prevent the entry of spermatozoa. To enhance efficacy, a spermicidal agent is often placed within the device. Antimicrobial agent(s) can also be used to prevent sexually transmitted diseases. Efficacy of vaginal diaphragm against infections is very limited.
C42768	Security_Role_Object	UML_Entity	Security Role Object|Role|Security Role	This class defines the security role object in context of an application. The roles are collection of privileges.
C42769	Wound_Dressing_Material	Medical_Device	Wound Dressing Material	The material used for protecting the wound site from external factors that disrupt healing and cause infection and pain. Effective dressing protects and manages the microenvironment of the healing wound. Management of the wound environment includes consideration of moisture, temperature and the presence of pathogens.
C42770	Generator	Medical_Device	Generator
C42771	Intrauterine_Device	Contraceptive_Device	Intrauterine Contraceptive Device|IUCD|Intrauterine Device	A device usually made of plastic or metal, inserted into the uterus to prevent conception. IUCD can be a coil, loop, triangle o T in shape; its material can be impregnated with a pharmaceutical agent. The primary action of all IUCDs is the induction of a foreign-body reaction within the endometrium. This sterile inflammatory process is toxic to gametes, primarily spermatozoa, and effectively prevents viable sperm from passing into the fallopian tubes. The copper-bearing device has an independent toxic effect on spermatozoa. The progestin-releasing devices produce changes in endometrial architecture and function that reduce the potential for implantation of a fertilized egg. The progestin effect on the cervical mucus also reduces the penetrability of sperm.
C42773	Neoplastic_Promyelocytes_in_Bone_Marrow_Markedly_Increased	Granulocytes_Increased_in_Bone_Marrow	Neoplastic Promyelocytes in Bone Marrow Markedly Increased
C42774	Document_Title	Document_Type	Title	A general or descriptive designator for an object, work of art, or literary composition.
C42775	Email_Address	Document_Type	E-mail Address|E-mail|Electronic Mail Address|Email|Email Address	A text string identifier for a location to which e-mail can be delivered.
C42776	Immature_Myeloid_Cells_Increased_in_Bone_Marrow	Abnormal_Bone_Marrow_Test_Result	Immature Myeloid Cells Increased in Bone Marrow
C42777	Definition	Document_Type	Definition	A concise explanation of the meaning of a word or phrase or symbol.
C42778	Uniform_Resource_Identifier	Identifier	Uniform Resource Identifier|URI	A character string that can identify any kind of resource on the Internet, including images, text, video, audio and programs.  The most commom type of a URI is a URL. (from http://www.computeruser.com)
C42779	Acute_Myelomonocytic_Leukemia_without_Abnormal_Eosinophils	Acute_Myelomonocytic_Leukemia	Acute Myelomonocytic Leukemia without Abnormal Eosinophils
C42780	Bone_Marrow_Myeloid_Stem_Cell_with_Some_Commitment_to_Monocytic_Differentiation	Myeloid_Progenitor_Cell	Bone Marrow Stem Cell with Some Commitment to Monocytic Differentiation	A primitive, undifferentiated blood cell which can undergo division and tends to give rise to a blood cell of the monocyte lineage.
C42781	Author	Person	Author|Authors|Writer	The writer of a book, article, or other text.
C42782	Approval	Conceptual_Entities	Approval	Acceptance as satisfactory.
C42783	Page	Document_Type	Page|Pages	One side of one leaf (of a book or magazine or newspaper or letter etc.) or the written or pictorial matter it contains.
C42784	Caspase_Activation	Enzyme_Induction	Caspase Activation	Caspase Activation involves induction of the activity of intracellular cysteine endopeptidase family members kept inactive by mitochondrial surface proteins (BcL-2 Family) and involved in initial signaling and downstream proteolytic cleavages (at P1 aspartic acids) in inflammation and apoptotic cell death when signals block BcL-2 function and activators initiate caspase cascades.
C42785	Caspase-Dependent_Apoptosis	Apoptosis	Caspase-Dependent Apoptosis	Characterized by distinctive nuclear and cytoplasmic morphologic changes, Caspase-Dependent Apoptosis is an active and selective process of cell destruction in multicellular organisms that involves the activity of intracellular cysteine endopeptidase family members kept inactive by mitochondrial surface proteins (BcL-2 Family) and involved in initial signaling and downstream proteolytic cleavages (at P1 aspartic acids) in apoptotic cell death when signals block BcL-2 function and activators initiate caspase cascades.
C42786	Caspase-Independent_Apoptosis	Apoptosis	Caspase-Independent Apoptosis	Caspase-Independent Apoptosis is a process of cell destruction in multicellular organisms that does not involve the activity of intracellular cysteine endopeptidase family members (Caspases) kept inactive by mitochondrial surface proteins (BcL-2 Family).
C42787	Retinoid_Receptor_Binding	Receptor_Interaction	Retinoid Receptor Binding	Retinoid Receptor Binding involves temporary non-covalent interaction through intermolecular physical forces of attraction with a member of the Nuclear Receptor Superfamily that modulate diverse cell functions when specifically bound to a retinoid or agonist.
C42788	Receptor_Down_Regulation	Receptor_Desensitization	Receptor Down Regulation	Due to internalization of ligand-receptor complexes, increased receptor turnover, or decreased receptor expression following exposure to a ligand or agent, Receptor Down Regulation involves a decrease in the number of ligand-specific cellular proteins that bind to, and mediate, the effects of a regulatory molecule.
C42789	Receptor_Tyrosine_Kinase_Down_Regulation	Receptor_Down_Regulation	Receptor Tyrosine Kinase Down Regulation	Due to internalization of ligand-receptor complexes, increased receptor turnover, or decreased receptor expression following exposure to a ligand or agent, Receptor Tyrosine Kinase Down Regulation involves a decrease in the number of ligand-specific cell membrane proteins that bind to, and mediate, the effects of a regulatory molecule and that have intrinsic cytoplasmic protein-tyrosine kinase activity integral to, and critical for, receptor function; the ligand-induced phosphorylation event alters the function of protein substrates involved in signal transduction pathways.
C42790	Experiment	Research_Activity	Experiment	A set of actions and observations, performed to verify or falsify a hypothesis or research a causal relationship between phenomena.
C42791	Inhibition	Conceptual_Entities	Inhibition	The interference with or prevention of an action or response even though the stimulus for that action or response is present.
C42792	LocusLink	Information_Resources	LocusLink	LocusLink is a web application from the National Center for Biotechnology Information (NCBI).  It provides a single query interface to curated sequence and descriptive information about genetic loci. It presents information on official nomenclature, aliases, sequence accessions, phenotypes, EC numbers, MIM numbers, UniGene clusters, homology, map locations, and related web sites.  It was replaced by Entrez Gene.
C42793	Kit	Diagnostic_Therapeutic_and_Research_Equipment	Kit
C42794	Drug_Packaging_Tube	Drug_Packaging_Device	Packaging Tube|TUBE	A flexible container for semisolid drug products which is flattened and crimped or sealed at one end and has a reclosable opening at the other.
C42795	Dental_Liner	Dental_Material	Dental Liner Material
C42796	Packing_Material	Medical_Device	Packing Material	A material used in medical and dental practice for filling a natural cavity or deep or tunneled wound. The packing absorbs drainage from the wound so the tissues can heal from the inside out. Without the packing, the wound could close without healing the deep areas of the wound.
C42797	Poultice	Medical_Device	Poultice|Cataplasm	A soft, moist mass or mush made by wetting a powder or other absorbent substance with oily or watery fluid; or prepared from meal, clay, or other adhesive substance, sometimes medicated, and usually applied hot to a given area in order to create local heat, decrease irritation and to exert an emollient, relaxing, or stimulant effect upon the skin and underlying tissues.
C42852	EVS_Code_Type	UML_Entity	EVS Code Type|EVS Source	The type of EVS concept code (e.g., NCI_CONCEPT_CODE, UML_CUI).
C42853	High_Value_Number	UML_Entity	High Value Number	Indicates the upper limit permissible for a value.
C42854	Label_Type_Flag	Flag	Label Type Flag	An indicator that specifies if the classification scheme is A= alphanumeric; C=character; N=numeric.
C42855	Long_Name	Retired_Concepts	Long Name|longName	A lengthier name possibly revealing more about an entity than the shorter Preferred Name but intended to have the same meaning.
C42856	Sponge	Medical_Device	Sponge	A soft flexible, absorbent pad usually made from natural material such as gauze or cotton, used to absorb blood and other fluids, as in surgery or the dressing of a wound. The term also refers to a small absorbent contraceptive pad that contains a spermicide and is placed against the cervix of the uterus before sexual intercourse.
C42857	Low_Value_Number	UML_Entity	Low Value Number	Indicates the lower limit permissible for a value.
C42858	Suture_Material	Medical_Device	Suture Material	A natural (e.g. catgut, silk, or linen) or synthetic, or other (e.g. thin metal wire) monofilament or multifilament material used surgically to close a surgical or accidental wound and to secure apposition of the edges and join tissues. Three properties of a suture material affect its handling: memory, elasticity, and knot strength. Tensile strength, tissue reaction, and capability to be absorbed are other important characteristics of the suture material. The selection of the type of suture to be used depends on tissue type and anatomical location.
C42859	Public_Identifier	Retired_Concepts	Public Identifier|publicID	A unique identifier for every administered component.
C42860	Tampon	Medical_Device	Tampon	A plug of absorbent material, e.g. cotton inserted into a body cavity or wound during the surgical intervention to check a flow of blood and arrest hemorrhaging, or to absorb body fluid secretions. Particularly, the concept refers to commercially manufactured small cylinder of cotton or other material which is placed in vagina to absorb menstrual blood.
C42861	Derivation_Rule	UML_Entity	Derivation Rule|Rule	The logical, mathematical, and/or other operations specifying derivation. The rule may range from a simple operation such as subtraction to a very complex set of derivations.
C42863	Tape	Medical_Device	Tape
C42865	Strip	Medical_Device	Strip
C42868	Source_Role	UML_Entity	Source Role	Role of the source class in the association.
C42869	Unresolved_Issue	UML_Entity	Unresolved Issue	Any problem that remains unresolved regarding proper documentation of the Administered Item. (ISO 11179)
C42871	Search_Criteria	UML_Entity	Search Criteria	An object that exists for defining the search parameters for a domain.
C42872	Washout_Period	Conceptual_Entities	Washout Period|Agent Washout|Washout	A period of time to allow one agent to clear the body before another agent can be safely introduced.  Washout periods vary depending on the agents involved.
C42873	Undifferentiated_Neoplastic_Blast	Neoplastic_Blast	Undifferentiated Neoplastic Blast
C42874	Abstract	General_Modifier	Abstract	A concept or idea not associated with any specific instance.
C42875	Neoplastic_Blast_Coexpressing_Myeloid_and_Lymphoid_Lineage_Antigens	Neoplastic_Blast	Neoplastic Blast Coexpressing Myeloid and Lymphoid Lineage Antigens|Neoplastic Blast Co-expressing Myeloid and Lymphoid Lineage Antigens
C42876	Dual_Population_of_Bone_Marrow_Blasts_Present	Blast_Cells_Increased_in_Bone_Marrow	Dual Population of Bone Marrow Blasts Present
C42877	Breeding	Clinical_or_Research_Activity	Breeding	The production of animals or plants by selective pairing.
C42878	Cancer_Bioinformatics_Infrastructure_Object_Model	Cancer_Research_Project	Cancer Bioinformatics Infrastructure Objects|Cancer Bioinformatics Infrastructure Object Model|caBIO	The vision for caCORE is to provide a common data management framework that will support the consistency, clarity, and comparability of biomedical research data and information. The cancer Bioinformatics Infrastructure Objects (caBIO) model and architecture is the primary programmatic interface to caCORE. The heart of caBIO is its domain objects, each of which represents an entity found in biomedical research. These domain objects are related to each other, and examining these relationships can bring to the surface biomedical knowledge that was previously buried in the various primary data sources. (http://ncicb.nci.nih.gov/core)
C42879	Fax_Number	Telephone_Number	Fax Number|FAX	A telephone number that is used for identifying a destination fax machine in a telephone network.
C42881	PubMed	Information_Resources	PubMed	A web application from the National Library of Medicine (NLM).  It provides a single query interface to over 15 million citations for biomedical articles back to the 1950's. These citations are from MEDLINE and additional life science journals. PubMed includes links to many sites providing full text articles and other related resources.
C42882	Released	General_Modifier	Release|Released	To make available; set free.
C42883	File	Document_Type	File	A set of related records (either written or electronic) kept together.
C42884	Bone_Marrow_Stem_Cell_with_Variable_Lineage_Potential	Bone_Marrow_Stem_Cell	Bone Marrow Stem Cell with Variable Lineage Potential	A bone marrow stem cell with variable lineage potential is an undifferentiated cell which can undergo division and give rise to a variety of hematopoietic cells.
C42885	Derived	General_Modifier	Derived	To take, obtain, or receive from a source; having been determined by mathematical computation.
C42886	Bioassay_Class	UML_Entity	Bioassay Class|Bioassay	An abstract class which represents both physical and computational groupings of arrays and biomaterials.
C42887	Aerosol_Dosage_Form	Pharmaceutical_Dosage_Form	Aerosol Dosage Form|AER|AEROSOL|Aerosol Dose Form	A product that is packaged under pressure and contains therapeutically active ingredients that are released upon activation of an appropriate valve system; it is intended for topical application to the skin as well as local application into the nose (nasal aerosols), mouth (lingual aerosols), or lungs (inhalation aerosols).
C42888	Aerosol_Foam_Dosage_Form	Aerosol_Dosage_Form	Aerosol Foam Dosage Form|AER FOAM|AEROSOL, FOAM|Aerosol Foam Dose Form	An emulsion containing one or more active ingredients, surfactants, aqueous or non-aqueous liquids, and the propellants; if the propellant is in the internal (discontinuous) phase (i.e., of the oil-in-water type), a stable foam is discharged, and if the propellant is in the external (continuous) phase (i.e., of the water-in-oil type), a spray or a quick-breaking foam is discharged.
C42889	Aerosol_Spray_Dosage_Form	Aerosol_Dosage_Form|Spray_Dosage_Form	Aerosol Spray Dosage Form|AER SPRAY|AEROSOL, SPRAY|Aerosol Spray Dose Form	An aerosol product which utilizes a compressed gas as the propellant to provide the force necessary to expel the product as a wet spray; it is applicable to solutions of medicinal agents in aqueous solvents.
C42890	Bead_Dosage_Form	Solid_Dosage_Form	Bead Dosage Form|BEAD|Bead Dose Form	A solid dosage form in the shape of a small ball.
C42891	Block_Dosage_Form	Solid_Dosage_Form	Block Dosage Form|BLOCK|Block Dose Form	Solid dosage form, usually in the shape of a square or rectangle.
C42892	Chewable_Bar_Dosage_Form	Solid_Dosage_Form	Chewable Bar Dosage Form|BAR CHEW|BAR, CHEWABLE|Chewable Bar Dose Form	A solid dosage form usually in the form of a rectangle that is meant to be chewed.
C42893	Chewable_Tablet_Dosage_Form	Oral_Tablet_Dosage_Form	Chewable Tablet Dosage Form|Chewable Tablet Dose Form|TAB CHEW|TABLET, CHEWABLE	A solid dosage form containing medicinal substances with or without suitable diluents that is intended to be chewed, producing a pleasant tasting residue in the oral cavity that is easily swallowed and does not leave a bitter or unpleasant after-taste.
C42894	Chewing_Gum_Dosage_Form	Gum_Dosage_Form	Chewing Gum Dosage Form|Chewing Gum Dose Form|GUM CHEWING|GUM, CHEWING	A sweetened and flavored insoluble plastic material of various shapes which when chewed, releases a drug substance into the oral cavity.
C42895	Coated_Capsule_Dosage_Form	Capsule	Coated Capsule Dosage Form|CAP COATED|CAPSULE, COATED|Coated Capsule Dose Form	A solid dosage form in which the drug is enclosed within either a hard or soft soluble container or "shell" made from a suitable form of gelatin; additionally, the capsule is covered in a designated coating.
C42896	Coated_Pellets_Capsule	Capsule	Coated Pellets in Capsule Dosage Form|CAP COATED PELLETS|CAPSULE, COATED PELLETS|Coated Pellets in Capsule Dose Form	A solid dosage form in which the drug is enclosed within either a hard or soft soluble container or "shell" made from a suitable form of gelatin; the drug itself is in the form of granules to which varying amounts of coating have been applied.
C42897	Coated_Tablet_Dosage_Form	Tablet_Dosage_Form	Coated Tablet Dosage Form|Coated Tablet Dose Form|TAB COATED|TABLET, COATED	A solid dosage form that contains medicinal substances with or without suitable diluents and is covered with a designated coating.
C42898	Concentrate_for_Solution_Dosage_Form	Solution_Dosage_Form	Concentrate for Solution Dosage Form|Concentrate For Solution Dosage Form|Concentrate For Solution Dose Form|Concentrated Solution Dosage Form|SOL CONC|SOLUTION, CONCENTRATE	A liquid preparation (i.e., a substance that flows readily in its natural state) that contains a drug dissolved in a suitable solvent or mixture of mutually miscible solvents; the drug has been strengthened by the evaporation of its non-active parts.
C42899	Concentrate_for_Solution_for_Injection	Injectable_Solution	Concentrate for Injectable Solution Dosage Form|Concentrate for Injectable Solution Dose Form|Concentrated Solution for Injection Dosage Form|INJ SOL CONC|INJECTION, SOLUTION, CONCENTRATE	A sterile preparation for parenteral use which, upon the addition of suitable solvents, yields a solution conforming in all respects to the requirements for Injections.
C42900	Cone_Dosage_Form	Solid_Dosage_Form	Cone Dosage Form|CONE|Cone Dose Form	A solid dosage form bounded by a circular base and the surface formed by line segments joining every point of the boundary of the base to a common vertex. A cone (usually containing antibiotics) is normally placed below the gingiva after a dental extraction.
C42901	Crystal_Dosage_Form	Solid_Dosage_Form	Crystal Dosage Form|CRYSTAL|Crystal Dose Form	A naturally produced angular solid of definite form in which the ultimate units from which it is built up are systematically arranged; they are usually evenly spaced on a regular space lattice.
C42902	Delayed_Release_Capsule	Capsule	Delayed Release Capsule Dosage Form|CAP DR|CAPSULE, DELAYED RELEASE|Delayed Release Capsule Dose Form	A solid dosage form in which the drug is enclosed within either a hard or soft soluble container made from a suitable form of gelatin, and which releases a drug (or drugs) at a time other than promptly after administration. Enteric-coated articles are delayed release dosage forms.
C42903	Delayed_Release_Granule_Dosage_Form	Granule_Dosage_Form	Delayed Release Granule Dosage Form|Delayed Release Granule Dose Form|GRAN DR|GRANULE, DELAYED RELEASE	A small medicinal particle or grain to which an enteric or other coating has been applied, thus delaying release of the drug until its passage into the intestines.
C42904	Delayed_Release_Pellets_Capsule	Capsule	Delayed Release Pellets in Capsule Dosage Form|CAP DR PELLETS|CAPSULE, DELAYED RELEASE PELLETS|Delayed Release Pellets in Capsule Dose Form	A solid dosage form in which the drug is enclosed within either a hard or soft soluble container or "shell" made from a suitable form of gelatin; the drug itself is in the form of granules to which enteric coating has been applied, thus delaying release of the drug until its passage into the intestines.
C42905	Delayed_Release_Tablet	Tablet_Dosage_Form	Delayed Release Tablet Dosage Form|Delayed Release Tablet Dose Form|TAB DR|TABLET, DELAYED RELEASE	A solid dosage form which releases a drug (or drugs) at a time other than promptly after administration. Enteric-coated articles are delayed release dosage forms.
C42906	Dentifrice_Gel_Dosage_Form	Gel_Dosage_Form	Dentifrice Gel Dosage Form|Dentifrice Gel Dose Form|GEL DENT|GEL, DENTIFRICE	A combination of a dentifrice (formulation intended to clean and/or polish the teeth, and which may contain certain additional agents), and a gel (a semisolid system which consists of suspensions made up of either small inorganic particles or large organic molecules interpenetrated by a liquid) and which is used with a toothbrush for the purpose of cleaning and polishing the teeth.
C42907	Dentifrice_Paste_Dosage_Form	Paste_Dosage_Form	Dentifrice Paste Dosage Form|Dentifrice Paste Dose Form|PASTE DENT|PASTE, DENTIFRICE	A paste formulation intended to clean and/or polish the teeth, and which may contain certain additional agents.
C42908	Dentifrice_Powder_Dosage_Form	Powder_Dosage_Form	Dentifrice Powder Dosage Form|Dentifrice Powder Dose Form|POWDER, DENTIFRICE|PWD DENT	A powder formulation intended to clean and/or polish the teeth, and which may contain certain additional agents.
C42909	Effervescent_Granule_Dosage_Form	Granule_Dosage_Form	Effervescent Granule Dosage Form|Effervescent Granule Dose Form|GRAN EFFRV|GRANULE, EFFERVESCENT	A small particle or grain containing a medicinal agent in a dry mixture usually composed of sodium bicarbonate, citric acid, and tartaric acid which, when in contact with water, has the capability to release gas, resulting in effervescence.
C42910	Effervescent_Tablet_Dosage_Form	Tablet_Dosage_Form	Effervescent Tablet Dosage Form|Effervescent Tablet Dose Form|TAB EFFRV|TABLET, EFFERVESCENT	A solid dosage form containing, in addition to active ingredients, mixtures of acids (citric acid, tartaric acid) and sodium bicarbonate, which release carbon dioxide when dissolved in water; it is intended to be dissolved or dispersed in water before administration.
C42911	Electrically_Controlled_Extended_Release_Patch	Extended_Release_Patch	Electrically Controlled Extended Release Patch Dosage Form|Electrically Controlled Extended Release Patch Dose Form|PATCH ER ELCON|PATCH, EXTENDED RELEASE, ELECTRICALLY CONTROLLED	A drug delivery system in the form of a patch which is controlled by an electric current that releases the drug in such a manner that a reduction in dosing frequency compared to that drug presented as a conventional dosage form (e.g., a solution or a prompt drug-releasing, conventional solid dosage form).
C42912	Elixir_Dosage_Form	Solution_Dosage_Form	Elixir Dosage Form|ELIXIR|Elixir Dose Form	A clear, pleasantly flavored, sweetened hydroalcoholic liquid containing dissolved medicinal agents; it is intended for oral use.
C42913	Emulsion_Dosage_Form	Pharmaceutical_Dosage_Form	Emulsion Dosage Form|EMULSION|Emulsion Dose Form	A two-phase system in which one liquid is dispersed throughout another liquid in the form of small droplets.
C42914	Emulsion_For_Injection	Emulsion_Dosage_Form	Emulsion For Injection Dosage Form|INJ EMULSION|INJECTION, EMULSION|Injectable Emulsion Dosage Form|Injectable Emulsion Dose Form	An emulsion, a two-phase system in which one liquid is dispersed throughout another liquid in the form of small droplets, consisting of a sterile, pyrogen-free preparation intended to be administered parenterally.
C42915	Enema_Dosage_Form	Solution_Dosage_Form	Enema Dosage Form|ENEMA|Enema Dose Form	A rectal preparation for therapeutic, diagnostic, or nutritive purposes.
C42916	Extended_Release_Capsule	Capsule	Extended Release Capsule Dosage Form|CAP ER|CAPSULE, EXTENDED RELEASE|Extended Release Capsule Dose Form	A solid dosage form in which the drug is enclosed within either a hard or soft soluble container made from a suitable form of gelatin, and which releases a drug (or drugs) in such a manner to allow a reduction in dosing frequency as compared to that drug (or drugs) presented as a conventional dosage form.
C42917	Extended_Release_Coated_Capsule	Coated_Capsule_Dosage_Form	Extended Release Coated Capsule Dosage Form|CAP COATED ER|CAPSULE, COATED, EXTENDED RELEASE|Extended Release Coated Capsule Dose Form	A solid dosage form in which the drug is enclosed within either a hard or soft soluble container or "shell" made from a suitable form of gelatin; additionally, the capsule is covered in a designated coating, and which releases a drug (or drugs) in such a manner to allow at least a reduction in dosing frequency as compared to that drug (or drugs) presented as a conventional dosage form.
C42918	Extended_Release_Coated_Pellet	Pellet_Dosage_Form	Extended Release Coated Pellets Dosage Form|Extended Release Coated Pellets Dose Form|PELLETS COATED ER|PELLETS, COATED, EXTENDED RELEASE	A solid dosage form in which the drug itself is in the form of granules to which varying amounts of coating have been applied, and which releases a drug (or drugs) in such a manner to allow a reduction in dosing frequency as compared to that drug (or drugs) presented as a conventional dosage form
C42919	Extended_Release_Core_Dosage_Form	Solid_Dosage_Form	Extended Release Core Dosage Form|CORE ER|CORE, EXTENDED RELEASE|Extended Release Core Dose Form	An ocular system placed in the eye from which the drug diffuses through a membrane at a constant rate over a specified period.
C42920	Extended_Release_Film_Dosage_Form	Film_Dosage_Form	Extended Release Film Dosage Form|Extended Release Film Dose Form|FILM ER|FILM, EXTENDED RELEASE	A drug delivery system in the form of a film that releases the drug over an extended period in such a way as to maintain constant drug levels in the blood or target tissue.
C42921	Extended_Release_Granule_For_Suspension_Dosage_Form	Granule_For_Suspension_Dosage_Form	Extended Release Granule For Suspension Dosage Form|Extended Release Granule For Suspension Dose Form|GRAN F/SUSP ER|GRANULE, FOR SUSPENSION, EXTENDED RELEASE	A small medicinal particle or grain made available in its more stable dry form, to be reconstituted with solvent just before dispensing to form a suspension; the extended release system achieves slow release of the drug over an extended period of time and maintains constant drug levels in the blood or target tissue.
C42922	Extended_Release_Insert	Solid_Dosage_Form	Extended Release Insert Dosage Form|Extended Release Insert Dose Form|INSERT ER|INSERT, EXTENDED RELEASE	A specially formulated and shaped solid preparation (e.g., ring, tablet, or stick) intended to be placed in the vagina by special inserters, where the medication is released, generally for localized effects; the extended release preparation is designed to allow a reduction in dosing frequency.
C42923	Extended_Release_Patch	Patch_Dosage_Form	Extended Release Patch Dosage Form|Extended Release Patch Dose Form|PATCH ER|PATCH, EXTENDED RELEASE	A drug delivery system in the form of a patch that releases the drug in such a manner that a reduction in dosing frequency compared to that drug presented as a conventional dosage form (e.g., a solution or a prompt drug-releasing, conventional solid dosage form).
C42924	Extended_Release_Suppository	Suppository_Dosage_Form	Extended Release Suppository Dosage Form|Extended Release Suppository Dose Form|SUPP ER|SUPPOSITORY, EXTENDED RELEASE	A drug delivery system in the form of a suppository that allows at least a reduction in dosing frequency.
C42925	Extended_Release_Suspension	Suspension_Dosage_Form	Extended Release Suspension Dosage Form|Extended Release Suspension Dose Form|SUSP ER|SUSPENSION, EXTENDED RELEASE	A liquid preparation consisting of solid particles dispersed throughout a liquid phase in which the particles are not soluble; the suspension has been formulated in a manner to allow at least a reduction in dosing frequency as compared to that drug presented as a conventional dosage form (e.g., as a solution or a prompt drug-releasing, conventional solid dosage form).
C42926	Extended_Release_Suspension_For_Injection	Extended_Release_Suspension	Injectable Extended Release Suspension Dosage Form|Extended Release Suspension For Injection Dosage Form|INJ SUSP ER|INJECTION, SUSPENSION, EXTENDED RELEASE|Injectable Extended Release Suspension Dose Form	A sterile preparation intended for parenteral use which has been formulated in a manner to allow at least a reduction in dosing frequency as compared to that drug presented as a conventional dosage form (e.g., as a solution or a prompt drug-releasing, conventional solid dosage form).
C42927	Extended_Release_Tablet	Tablet_Dosage_Form	Extended Release Tablet Dosage Form|Extended Release Tablet Dose Form|TAB ER|TABLET, EXTENDED RELEASE	A solid dosage form containing a drug which allows at least a reduction in dosing frequency as compared to that drug presented in conventional dosage form.
C42928	Extended_Release_Film_Coated_Capsule	Coated_Capsule_Dosage_Form	Extended Release Film Coated Capsule Dosage Form|CAP FILM COATED ER|CAPSULE, FILM COATED, EXTENDED RELEASE|Extended Release Film Coated Capsule Dose Form	A solid dosage form in which the drug is enclosed within either a hard or soft soluble container or "shell" made from a suitable form of gelatin; additionally, the capsule is covered in a designated film coating, and which releases a drug (or drugs) in such a manner to allow at least a reduction in dosing frequency as compared to that drug (or drugs) presented as a conventional dosage form.
C42929	Extract_Dosage_Form	Pharmaceutical_Dosage_Form	Extract Dosage Form|EXTRACT|Extract Dose Form	A concentrated preparation of vegetable or animal drugs obtained by removal of the active constituents of the respective drugs with a suitable menstrua, evaporation of all or nearly all of the solvent, and adjustment of the residual masses or powders to the prescribed standards.
C42930	Film_Coated_Extended_Release_Tablet	Film_Coated_Tablet_Dosage_Form	Film Coated Extended Release Tablet Dosage Form|Film Coated Extended Release Tablet Dose Form|TAB FILM COATED ER|TABLET, FILM COATED, EXTENDED RELEASE	A solid dosage form that contains medicinal substances with or without suitable diluents and is coated with a thin layer of a water-insoluble or water-soluble polymer; the tablet is formulated in such manner as to make the contained medicament available over an extended period of time following ingestion.
C42931	Film_Coated_Tablet_Dosage_Form	Coated_Tablet_Dosage_Form	Film Coated Tablet Dosage Form|Film Coated Tablet Dose Form|TAB FILM COATED|TABLET, FILM COATED	A solid dosage form that contains medicinal substances with or without suitable diluents and is coated with a thin layer of a water-insoluble or water-soluble polymer.
C42932	Film_Dosage_Form	Solid_Dosage_Form	Film Dosage Form|FILM|Film Dose Form	A thin layer or coating.
C42933	Gas_Dosage_Form	Pharmaceutical_Dosage_Form	Gas Dosage Form|GAS|Gas Dose Form	Any elastic aeriform fluid in which the molecules are separated from one another and have free paths.
C42934	Gel_Dosage_Form	Semisolid_Dosage_Form	Gel Dosage Form|GEL|GEL DOSAGE FORM|Gel Dose Form	A semisolid system consisting of either suspensions made up of small inorganic particles or large organic molecules interpenetrated by a liquid.
C42935	Gel_Forming_Extended_Release_Solution	Solution_Dosage_Form	Extended Release Gel Forming Solution Dosage Form|Extended Release Gel Forming Solution Dose Form|SOL GF ER|SOLUTION, GEL FORMING, EXTENDED RELEASE	A solution that forms a gel when it comes in contact with ocular fluid, and which allows at least a reduction in dosing frequency
C42936	Gelatin_Coated_Capsule_Dosage_Form	Coated_Capsule_Dosage_Form	Gelatin Coated Capsule Dosage Form|CAP GELATIN COATED|CAPSULE, GELATIN COATED|Gelatin Coated Capsule Dose Form	A solid dosage form in which the drug is enclosed within either a hard or soft soluble container made from a suitable form of gelatin; through a banding process, the capsule is coated with additional layers of gelatin so as to form a complete seal.
C42937	Globule_Dosage_Form	Solid_Dosage_Form	Globule Dosage Form|GLOBULE|Globule Dose Form	Also called pellets or pilules, are made of pure sucrose, lactose, or other polysaccharides. They are formed into small globular masses of various sizes, and are medicated by placing them in a vial and adding the liquid drug attenuation in the proportion not less than one percent (v/w). After shaking, the medicated globules are dried at temperatures not to exceed 40 degrees Centigrade.
C42938	Granule_Dosage_Form	Solid_Dosage_Form	Granule Dosage Form|GRAN|GRANULE|Granule Dose Form	A small particle or grain.
C42939	Granule_For_Solution_Dosage_Form	Granule_Dosage_Form	Granule For Solution Dosage Form|GRAN F/SOL|GRANULE, FOR SOLUTION|Granule For Solution Dose Form	A small medicinal particle or grain made available in its more stable dry form, to be reconstituted with solvent just before dispensing; the granules are so prepared to contain not only the medicinal agent, but the colorants, flavorants, and any other desired pharmaceutic ingredient. (Dorland's Illustrated Medical Dictionary, 24th Ed.; INTRODUCTION TO PHARMACEUTICAL DOSAGE FORMS, 4th Ed.)
C42940	Granule_For_Suspension_Dosage_Form	Granule_Dosage_Form	Granule For Suspension Dosage Form|GRAN F/SUS|GRANULE, FOR SUSPENSION|Granule For Suspension Dose Form	A small medicinal particle or grain made available in its more stable dry form, to be reconstituted with solvent just before dispensing to form a suspension; the granules are so prepared to contain not only the medicinal agent, but the colorants, flavorants, and any other desired pharmaceutic ingredient.
C42941	Gum_Dosage_Form	Solid_Dosage_Form	Gum Dosage Form|GUM|Gum Dose Form	A mucilaginous excretion from various plants.
C42942	Implant_Dosage_Form	Solid_Dosage_Form	Implant Dosage Form|IMP|IMPLANT|Implant Dose Form	A material containing drug intended to be inserted securely of deeply in a living site for growth, slow release, or formation of an organic union.
C42943	Implantable_Pellet_Dosage_Form	Implant_Dosage_Form|Pellet_Dosage_Form	Implantable Pellet Dosage Form|Implantable Pellet Dose Form|PELLET IMP|PELLET, IMPLANTABLE	A small sterile solid mass consisting of a highly purified drug (with or without excipients) made by the formation of granules, or by compression and molding; they are intended for implantation in the body (usually subcutaneously) for the purpose of providing continuous release of the drug over long periods of time.
C42944	Inhalant_Dosage_Form	Pharmaceutical_Dosage_Form	Inhalant Dosage Form|INHALANT|Inhalant Dose Form	A special class of inhalations consisting of a drug or combination of drugs, that by virtue of their high vapor pressure, can be carried by an air current into the nasal passage where they exert their effect; the container from which the inhalant generally is administered is known as an inhaler.
C42945	Injectable_Solution	Solution_Dosage_Form	Injectable Solution Dosage Form|INJ SOL|INJECTION, SOLUTION|Injectable Solution Dose Form	A liquid preparation containing one or more drug substances dissolved in a suitable solvent or mixture of mutually miscible solvents that is suitable for injection.
C42946	Injection_Dosage_Form	Pharmaceutical_Dosage_Form	Injectable Dosage Form|INJ|INJECTION|Injectable Dose Form|Injection Dosage Form|Injection Dose Form	A sterile preparation intended for parenteral use; five distinct classes of injections exist as defined by the USP.
C42947	Irrigant_Dosage_Form	Solution_Dosage_Form	Irrigant Dosage Form|IRRIGANT|Irrigant Dose Form	A sterile solution intended to bathe or flush open wounds or body cavities; they're used topically, never parenterally.
C42948	Jelly_Gel_Dosage_Form	Gel_Dosage_Form	Jelly Gel Dosage Form|GEL JELLY|GEL, JELLY|Jelly Gel Dose Form	A class of gels--semisolid systems which consist of suspensions made up of either small inorganic particles or large organic molecules interpenetrated by a liquid--in which the structural coherent matrix contains a high portion of liquid, usually water.
C42949	Liniment_Dosage_Form	Solution_Dosage_Form	Liniment Dosage Form|LINIMENT|Liniment Dose Form	A solution or mixture of various substances in oil, alcoholic solutions of soap, or emulsions intended for external application.
C42950	Lipid_Complex_For_Injection	Injection_Dosage_Form	Injectable Lipid Complex Dosage Form|INJ LIPID COMPLEX|INJECTION, LIPID COMPLEX|Injectable Lipid Complex Dose Form|Lipid Complex For Injection Dosage Form	[definition pending]
C42951	Liposomal_Suspension_For_Injection	Suspension_For_Injection	Injectable Liposomal Suspension Dosage Form|INJ SUSP LIPOS|INJECTION, SUSPENSION, LIPOSOMAL|Injectable Liposomal Suspension Dose Form|Liposomal Suspension For Injection Dosage Form	A liquid parenteral pharmaceutical dosage form structured as a multilamellar composition of concentric phospholipid spheres that encapsulate the drug (drug delivery systems) separated by layers of water. Drug release is facilitated and controlled by in vivo erosion of the liposomes. To further increase the in vivo circulation time, liposomes in some preparations are covalently derivatized with PEG to produce PEGylated or stealth liposomes. Covalent attachment of drugs to the outer surface of liposomes can potentially serve as a delayed-release product.
C42952	Lipstick_Dosage_Form	Solid_Dosage_Form	Lipstick Dosage Form|LIPSTICK|Lipstick Dose Form	A waxy solid, usually colored cosmetic, in stick form for the lips.
C42953	Liquid_Dosage_Form	Pharmaceutical_Dosage_Form	Liquid Dosage Form|LIQ|LIQUID|Liquid Dose Form	A state of substance that is an intermediate one entered into as matter goes from solid to gas; liquids are also intermediate in that they have neither the orderliness of a crystal nor the randomness of a gas. (Note: This term should not be used to describe solutions, only pure chemicals in their liquid state.)
C42954	Liquid_Filled_Capsule_Dosage_Form	Capsule	Liquid Filled Capsule Dosage Form|CAP LIQ FILLED|CAPSULE, LIQUID FILLED|Liquid Filled Capsule Dose Form	A solid dosage form in which the drug is enclosed within a soluble, gelatin shell which is plasticized by the addition of a polyol, such as sorbitol or glycerin, and is therefore of a somewhat thicker consistency than that of a hard shell capsule; typically, the active ingredients are dissolved or suspended in a liquid vehicle.
C42955	Lozenge_Dosage_Form	Solid_Dosage_Form	Lozenge Dosage Form|LOZENGE|Lozenge Dose Form	A solid preparation containing one or more medicaments, usually in a flavored, sweetened base which is intended to dissolve or disintegrate slowly in the mouth. A lollipop is a lozenge on a stick.
C42956	Lyophilized_Powder_For_Extended_Release_Injectable_Suspension	Lyophilized_Powder_For_Injectable_Suspension	Lyophilized Powder For Extended Release Injectable Suspension Dosage Form|INJ PWD LYO F/SUSPER|INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION, EXTENDED RELEASE|Injectable Lyophilized Powder for Extended Release Suspension Dosage Form|Lyophilized Powder For Extended Release Injectable Suspension Dose Form	A sterile freeze dried preparation intended for reconstitution for parenteral use which has been formulated in a manner to allow at least a reduction in dosing frequency as compared to that drug presented as a conventional dosage form (e.g., as a solution).
C42957	Lyophilized_Powder_For_Injectable_Solution	Powder_For_Solution_for_Injection	Lyophilized Powder For Injectable Solution Dosage Form|INJ PWD LYO F/SOL|INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION|Injectable Lyophilized Powder for Solution Dosage Form|Lyophilized Powder For Injectable Solution Dose Form|Lyophilized Powder For Solution For Injection Dosage Form	A dosage form intended for the solution prepared by lyophilization ('freeze drying'), a process which involves the removal of water from products in the frozen state at extremely low pressures; this is intended for subsequent addition of liquid to create a solution that conforms in all respects to the requirements for Injections.
C42958	Lyophilized_Powder_For_Injectable_Suspension	Powder_For_Suspension_For_Injection	Lyophilized Powder For Injectable Suspension Dosage Form|INJ PWD LYO F/SUSP|INJECTION, POWDER, LYOPHILIZED, FOR SUSPENSION|Injectable Lyophilized Powder for Suspension Dosage Form|Lyophilized Powder For Injectable Suspension Dose Form|Lyophilized Powder For Suspension For Injection Dosage Form	A liquid preparation, intended for parenteral use, that contains solids suspended in a suitable fluid medium and conforms in all respects to the requirements for Sterile Suspensions; the medicinal agents intended for the suspension are prepared by lyophilization ("freeze drying"), a process which involves the removal of water from products in the frozen state at extremely low pressures.
C42959	Lyophilized_Powder_For_Liposomal_Suspension_For_Injection	Lyophilized_Powder_For_Injectable_Suspension	Lyophilized Powder For Injectable Liposomal Suspension Dosage Form|INJ PWD LYO F/LS|INJECTION, POWDER, LYOPHILIZED, FOR LIPOSOMAL SUSPENSION|Injectable Lyophilized Powder for Liposomal Suspension Dosage Form|Lyophilized Powder For Injectable Liposomal Suspension Dose Form|Lyophilized Powder For Liposomal Suspension For Injection Dosage Form	A sterile freeze dried preparation intended for reconstitution for parenteral use which has been formulated in a manner that would allow liposomes (a lipid bilayer vesicle usually composed of phospholipids which is used to encapsulate an active drug substance, either within a lipid bilayer or in an aqueous space) to be formed upon reconstitution.
C42960	Metered_Aerosol_Dosage_Form	Aerosol_Dosage_Form	Metered Aerosol Dosage Form|AER MET|AEROSOL, METERED|Metered Aerosol Dose Form	A pressurized dosage form consisting of metered dose valves which allow for the delivery of a uniform quantity of spray upon each activation.
C42961	Metered_Powder_Dosage_Form	Powder_Dosage_Form	Metered Powder Dosage Form|Metered Powder Dose Form|POWDER, METERED|PWD MET	A powder dosage form that is situated inside a container that has a mechanism to deliver a specified quantity.
C42962	Metered_Spray_Dosage_Form	Spray_Dosage_Form	Metered Spray Dosage Form|Metered Spray Dose Form|SPRAY MET|SPRAY, METERED	A non-pressurized dosage form consisting of valves which allow the dispensing of a specified quantity of spray upon each activation.
C42963	Multilayered_Extended_Release_Tablet	Multilayered_Tablet_Dosage_Form	Multilayered Extended Release Tablet Dosage Form|Multilayered Extended Release Tablet Dose Form|TAB MULTILAYER ER|TABLET, MULTILAYER, EXTENDED RELEASE	A solid dosage form containing medicinal substances that have been compressed to form a multiple-layered tablet or a tablet-within-a-tablet, the inner tablet being the core and the outer portion being the shell, which, additionally, is covered in a designated coating; the tablet is formulated in such manner as to allow at least a reduction in dosing frequency as compared to that drug presented as a conventional dosage form.
C42964	Multilayered_Tablet_Dosage_Form	Tablet_Dosage_Form	Multilayered Tablet Dosage Form|Multilayered Tablet Dose Form|TAB MULTILAYER|TABLET, MULTILAYER	A solid dosage form containing medicinal substances that have been compressed to form a multiple-layered tablet or a tablet-within-a-tablet, the inner tablet being the core and the outer portion being the shell.
C42965	Oil_Dosage_Form	Pharmaceutical_Dosage_Form	Oil Dosage Form|OIL|Oil Dose Form	An unctuous, combustible substance which is liquid, or easily liquefiable, on warming, and is soluble in ether but insoluble in water. Such substances, depending on their origin, are classified as animal, mineral, or vegetable oils.
C42966	Ointment_Dosage_Form	Semisolid_Dosage_Form	Ointment Dosage Form|OINTMENT|Ointment Dose Form	A semisolid preparation intended for external application to the skin or mucous membranes.
C42967	Paste_Dosage_Form	Semisolid_Dosage_Form	Paste Dosage Form|PASTE|Paste Dose Form	A semisolid dosage form that contains one or more drug substances intended for topical application.
C42968	Patch_Dosage_Form	Solid_Dosage_Form	Patch Dosage Form|PATCH|Patch Dose Form	A drug delivery system that contains an adhesive backing and that permits its ingredients to diffuse from some portion of it (e.g., the backing itself, a reservoir, the adhesive, or some other component) into the body from the external site where it is applied.
C42969	Pellet_Dosage_Form	Solid_Dosage_Form	Pellet Dosage Form|PELLET|Pellet Dose Form	A small sterile solid mass consisting of a highly purified drug (with or without excipients) made by the formation of granules, or by compression and molding.
C42970	Plaster_Dosage_Form	Solid_Dosage_Form	Plaster Dosage Form|PLASTER|Plaster Dose Form	Substance intended for external application made of such materials and of such consistency as to adhere to the skin and attach to a dressing; plasters are intended to afford protection and support and/or to furnish an occlusion and macerating action and to bring medication into close contact with the skin.
C42971	Powder_Aerosol_Dosage_Form	Aerosol_Dosage_Form	Powder Aerosol Dosage Form|AER PWD|AEROSOL, POWDER|Powder Aerosol Dose Form	A product that is packaged under pressure and contains therapeutically active ingredients, in the form of a powder, that are released upon activation of an appropriate valve system.
C42972	Powder_Dosage_Form	Solid_Dosage_Form	Powder Dosage Form|POWDER|PWD|Powder Dose Form	An intimate mixture of dry, finely divided drugs and/or chemicals that may be intended for internal or external use.
C42973	Powder_for_Solution_Dosage_Form	Powder_Dosage_Form	Powder for Solution Dosage Form|POWDER, FOR SOLUTION|PWD F/SOL|Powder for Solution Dose Form	An intimate mixture of dry, finely divided drugs and/or chemicals, which, upon the addition of suitable vehicles, yields a solution.
C42974	Powder_For_Solution_for_Injection	Powder_for_Solution_Dosage_Form	Powder For Injectable Solution Dosage Form|INJ PWD F/SOL|INJECTION, POWDER, FOR SOLUTION|Injectable Powder for Solution Dosage Form|Powder For Injectable Solution Dose Form|Powder For Solution For Injection Dosage Form	A sterile preparation intended for reconstitution to form a solution for parenteral use.
C42975	Powder_for_Suspension_Dosage_Form	Powder_Dosage_Form	Powder for Suspension Dosage Form|POWDER, FOR SUSPENSION|PWD F/SUSP|Powder for Suspension Dose Form	An intimate mixture of dry, finely divided drugs and/or chemicals, which, upon the addition of suitable vehicles, yields a suspension (a liquid preparation containing the solid particles dispersed in the liquid vehicle).
C42976	Powder_For_Suspension_For_Injection	Powder_for_Suspension_Dosage_Form	Powder For Injectable Suspension Dosage Form|INJ PWD F/SUSP|INJECTION, POWDER, FOR SUSPENSION|Injectable Powder For Suspension Dosage Form|Powder For Injectable Suspension Dose Form|Powder For Suspension For Injection Dosage Form|Powder For Suspension For Injection Dose Form	A sterile preparation intended for reconstitution to form a suspension for parenteral use.
C42977	Powder_For_Suspension_For_Injection_Extended_Release_Dosage_Form	Powder_For_Suspension_For_Injection	Powder For Injectable Extended Release Suspension Dosage Form|INJ PWD F/SUSP ER|INJECTION, POWDER, FOR SUSPENSION, EXTENDED RELEASE|Injectable Powder For Extended Release Suspension Dosage Form|Powder For Extended Release Suspension For Injection Dosage Form|Powder For Injectable Extended Release Suspension Dose Form	A sterile freeze dried preparation intended for reconstitution to form a suspension for parenteral use which has been formulated in a manner to allow at least a reduction in dosing frequency as compared to that drug presented as a conventional dosage form (e.g., as a solution).
C42978	Resin_Gum_Dosage_Form	Gum_Dosage_Form	Resin Gum Dosage Form|GUM RESIN|GUM, RESIN|Resin Gum Dose Form	Natural mixture of gum and resin, usually obtained as exudations from plants.
C42979	Rinse_Dosage_Form	Solution_Dosage_Form	Rinse Dosage Form|RINSE|Rinse Dose Form	A liquid used to cleanse by flushing.
C42980	Salve_Dosage_Form	Semisolid_Dosage_Form	Salve Dosage Form|SALVE|Salve Dose Form	A thick ointment or cerate (a fat or wax based preparation with a consistency between an ointment and a plaster).
C42981	Shampoo_Dosage_Form	Pharmaceutical_Dosage_Form	Shampoo Dosage Form|SHAMPOO|Shampoo Dose Form	A liquid soap or detergent used to clean the hair and scalp and is often used as a vehicle for dermatologic agents.
C42982	Shampoo_Suspension_Dosage_Form	Shampoo_Dosage_Form	Shampoo Suspension Dosage Form|SHAMPOO SUSP|SHAMPOO, SUSPENSION|Shampoo Suspension Dose Form	A liquid soap or detergent containing one or more solid, insoluble substances dispersed in a liquid vehicle that is used to clean the hair and scalp and is often used as a vehicle for dermatologic agents.
C42983	Soap_Dosage_Form	Pharmaceutical_Dosage_Form	Soap Dosage Form|SOAP|Soap Dose Form	Any compound of one or more fatty acids, or their equivalents, with an alkali; soap is detergent and is much employed in liniments, enemas, and in making pills. It is also a mild aperient, antacid and antiseptic.
C42984	Soluble_Film_Dosage_Form	Film_Dosage_Form	Soluble Film Dosage Form|FILM SOLUBLE|FILM, SOLUBLE|Soluble Film Dose Form	A thin layer or coating which is susceptible to being dissolved when in contact with a liquid.
C42985	Soluble_Tablet_Dosage_Form	Tablet_Dosage_Form	Soluble Tablet Dosage Form|Soluble Tablet Dose Form|TAB SOLUBLE|TABLET, SOLUBLE	A solid dosage form that contains medicinal substances with or without suitable diluents and possesses the ability to dissolve in fluids.
C42986	Solution_Dosage_Form	Pharmaceutical_Dosage_Form	Solution Dosage Form|SOL|SOLUTION|Solution Dose Form	A liquid preparation that contains one or more chemical substances dissolved, i.e., molecularly dispersed, in a suitable solvent or mixture of mutually miscible solvents.
C42987	Solution_for_Slush_Dosage_Form	Solution_Dosage_Form	Solution For Slush Dosage Form|SOL F/SLUSH|SOLUTION, FOR SLUSH|Solution For Slush Dose Form	A solution for the preparation of an iced saline slush, which is administered by irrigation and used to induce regional hypothermia (in conditions such as certain open heart and kidney surgical procedures) by its direct application.
C42988	Sonicated_Suspension_For_Injection	Suspension_For_Injection	Injectable Sonicated Suspension Dosage Form|INJ SUSP SON|INJECTION, SUSPENSION, SONICATED|Injectable Sonicated Suspension Dose Form|Sonicated Suspension For Injection Dosage Form	A liquid preparation, suitable for injection, which consists of solid particles dispersed throughout a liquid phase in which the particles are not soluble. In addition, the product is sonicated while a gas is bubbled through the suspension, and this results in the formation of microspheres by the solid particles.
C42989	Spray_Dosage_Form	Pharmaceutical_Dosage_Form	Spray Dosage Form|SPRAY|Spray Dose Form	A liquid minutely divided as by a jet of air or steam.
C42990	Spray_Suspension_Dosage_Form	Suspension_Dosage_Form	Spray Suspension Dosage Form|SPRAY SUSP|SPRAY, SUSPENSION|Spray Suspension Dose Form	A liquid preparation containing solid particles dispersed in a liquid vehicle and in the form of coarse droplets or as finely divided solids to be applied locally, most usually to the nasal-pharyngeal tract, or topically to the skin.
C42991	Stick_Dosage_Form	Solid_Dosage_Form	Stick Dosage Form|STICK|Stick Dose Form	A dosage form prepared in a relatively long and slender often cylindrical form.
C42992	Sugar_Coated_Tablet_Dosage_Form	Oral_Tablet_Dosage_Form	Sugar Coated Tablet Dosage Form|Sugar Coated Tablet Dose Form|TAB SUGAR COATED|TABLET, SUGAR COATED	A solid dosage form that contains medicinal substances with or without suitable diluents and is coated with a colored or an uncolored water-soluble sugar.
C42993	Suppository_Dosage_Form	Solid_Dosage_Form	Suppository Dosage Form|SUPP|SUPPOSITORY|Suppository Dose Form	A solid body of various weights and shapes, adapted for introduction into the rectal, vaginal, or urethral orifice of the human body; they usually melt, soften, or dissolve at body temperature.
C42994	Suspension_Dosage_Form	Pharmaceutical_Dosage_Form	Suspension Dosage Form|SUSP|SUSPENSION|Suspension Dose Form	A liquid preparation which consists of solid particles dispersed throughout a liquid phase in which the particles are not soluble.
C42995	Suspension_For_Injection	Suspension_Dosage_Form	Injectable Suspension Dosage Form|INJ SUSP|INJECTION, SUSPENSION|Injectable Suspension Dose Form|Suspension For Injection Dosage Form	A liquid preparation, suitable for injection, which consists of solid particles dispersed throughout a liquid phase in which the particles are not soluble. It can also consist of an oil phase dispersed throughout an aqueous phase, or vice-versa.
C42996	Syrup_Dosage_Form	Solution_Dosage_Form	Syrup Dosage Form|SYRUP|Syrup Dose Form	An oral solution containing high concentrations of sucrose or other sugars; the term has also been used to include any other liquid dosage form prepared in a sweet and viscid vehicle, including oral suspensions.
C42997	Tablet_Delayed_Release_Particles_Dosage_Form	Tablet_Dosage_Form	Delayed Release Particles Tablet Dosage Form|Delayed Release Particles Tablet Dose Form|TAB DR PARTICLES|TABLET, DELAYED RELEASE PARTICLES	A solid dosage form containing a conglomerate of medicinal particles that have been covered with a coating which releases a drug (or drugs) at a time other than promptly after administration. Enteric-coated articles are delayed release dosage forms.
C42998	Tablet_Dosage_Form	Solid_Dosage_Form	Tablet Dosage Form|TAB|TABLET|Tablet Dose Form	A solid dosage form containing medicinal substances with or without suitable diluents.
C42999	Tablet_Orally_Disintegrating	Oral_Tablet_Dosage_Form	Orally Disintegrating Tablet Dosage Form|Orally Disintegrating Tablet Dose Form|TAB ORALLY DIS|TABLET, ORALLY DISINTEGRATING	A solid dosage form containing medicinal substances which disintegrates rapidly, usually within a matter of seconds, when placed upon the tongue.
C43000	Tincture_Dosage_Form	Pharmaceutical_Dosage_Form	Tincture Dosage Form|TINCTURE|Tincture Dose Form	An alcoholic or hydroalcoholic solution prepared from vegetable materials or from chemical substances.
C43001	Troche_Dosage_Form	Solid_Dosage_Form	Troche Dosage Form|TROCHE|Troche Dose Form	A discoid-shaped solid containing the medicinal agent in a suitably flavored base; troches are placed in the mouth where they slowly dissolve, liberating the active ingredients.
C43002	Unassigned_Dosage_Form	Pharmaceutical_Dosage_Form	Unassigned Dosage Form|UNASSIGNED|Unassigned Dose Form	A dosage form has yet to be assigned.
C43003	Wafer_Dosage_Form	Solid_Dosage_Form	Wafer Dosage Form|WAFER|Wafer Dose Form	A thin slice of material containing a medicinal agent.
C43005	DEK-CAN_Fusion_Protein_Expression	Fusion_Protein_Expression	DEK-CAN Fusion Protein Expression
C43006	Myeloblasts_90_Percent_or_More_of_Bone_Marrow_Non-Erythroid_Cells	Myeloblasts_20_Percent_or_More_of_Bone_Marrow_Nucleated_Cells	Myeloblasts 90 Percent or More of Bone Marrow Non-Erythroid Cells
C43164	Drug_Packaging_Device	Medical_Device	Package Type|PACKAGE TYPE	This standard provides for all types of packages that bulk drug substances and final drug dosage forms are contained in, including both the immediate (or primary) and secondary containers.
C43165	Ampule	Drug_Packaging_Device	Ampule|AMP|AMPULE	A container capable of being hermetically sealed, intended to hold sterile materials.
C43166	Drug_Applicator	Drug_Packaging_Device	Applicator|AP|APPLICATOR	A pre-filled non-injectable pipette, syringe or tube.
C43167	Bag	Drug_Packaging_Device	Bag|BAG	A sac or pouch.
C43168	Blister_Pack	Drug_Packaging_Device	Blister Pack|BLISTER PACK|BLPK	A package that consists of molded plastic or laminate that has indentations (viewed as 'blisters' when flipped) into which a dosage form, is placed. A covering, usually of laminated material, is then sealed to the molded part. A strip pack is a specialized type of blister pack where there are no pre-formed or molded parts; in this case there are two flexible layers that are sealed with the dosage form in between. Suppositories that are strip packed between two layers of foil are also considered a blister pack.
C43169	Bottle	Drug_Packaging_Device	Bottle|BOT|BOTTLE	A vessel with a narrow neck designed to accept a specific closure.
C43170	Dispensing_Bottle	Bottle	Dispensing Bottle|BOTDIS|BOTTLE, DISPENSING	A bottle that is used by the pharmacist to dispense the prescribed medication. It includes preparations for which a dropper accompanies the bottle.
C43171	Dropper_Bottle	Bottle	Dropper Bottle|BOTDR|BOTTLE, DROPPER	A bottle that has a device specifically intended for the application of a liquid in a drop by drop manner, or a device intended for the delivery of an exact dose (e.g., calibrated dropper for oral medications).
C43172	Glass_Bottle	Bottle	Glass Bottle|BOTGL|BOTTLE, GLASS	A glass vessel with a narrow neck designed to accept a specific closure.
C43173	Plastic_Bottle	Bottle	Plastic Bottle|BOTPL|BOTTLE, PLASTIC	A plastic vessel with a narrow neck designed to accept a specific closure.
C43174	Pump_Bottle	Bottle	Pump Bottle|BOTPU|BOTTLE, PUMP	A bottle that is fitted with a pumping mechanism for the administration of drug product.
C43175	Spray_Bottle	Bottle	Spray Bottle|BOTSPR|BOTTLE, SPRAY	A bottle that is fitted with an atomizer or a device which produces finely divided liquid carried by air.
C43176	Unit_Dose_Bottle	Bottle	Unit Dose Bottle|BOTTLE, UNIT-DOSE|BOTUD	A bottle that contains a single whole dose of a non-parenteral drug product.
C43177	Applicator_Bottle	Bottle|Drug_Applicator	Applicator Bottle|BOTAP|BOTTLE, WITH APPLICATOR	A bottle which includes a device for applying its contents.
C43178	Box	Drug_Packaging_Device	Box|BOX	A square or rectangular vessel, usually made of cardboard or plastic.
C43179	Unit_Dose_Box	Box	Unit Dose Box|BOX, UNIT-DOSE|BOXUD	A box that contains a single dose of a non-parenteral drug product. [Note: Boxes that contain 100 unit dose blister packs should be classified under blister pack, since this is the immediate container into which the dosage form is placed.]
C43180	Can	Drug_Packaging_Device	Can|CAN	A cylindrical vessel, usually made of metal.
C43181	Drug_Canister	Can	Canister|CANISTER|CSTR	A type of can for holding a drug product.
C43182	Carton	Drug_Packaging_Device	Carton|CARTON|CRTN	A cardboard box or container which is usually considered a secondary packaging component.
C43183	Drug_Cartridge	Drug_Packaging_Device	Cartridge|CARTRIDGE|CTG	A container consisting of a cylinder with a septum at one end, and a seal at the other end, which is inserted into a device to form a syringe which contains a single dose of a parenteral drug product.
C43184	Packaging_Case	Drug_Packaging_Device	Packaging Case|CASE	A receptacle for holding something (e.g., that into which some oral contraceptive blister packs are placed).
C43185	Cello_Pack	Drug_Packaging_Device	Cello Pack|CELLO|CELLO PACK	A plastic 'clamshell' [thin plastic pre-formed structure for a device].
C43186	Container	Drug_Packaging_Device	Container|CONTAINER|CTR	A receptacle designed to hold a specific dosage form.
C43187	Cup	Drug_Packaging_Device	Cup|CUP	A bowl-shaped container.
C43188	Unit_Dose_Cup	Cup	Unit Dose Cup|CUP, UNIT-DOSE|CUPUD	A cup intended to hold a single dose of a non-parenteral drug product.
C43189	Gas_Cylinder	Drug_Packaging_Device	Gas Cylinder|CYL|CYLINDER	A container designed specifically to hold gases.
C43190	Dewar	Drug_Packaging_Device	Dewar|DEW|DEWAR	A container, usually made of glass or metal, that has at least two walls with the space between each wall evacuated so as to prevent the transfer of heat. The inside of the container often has a coating (as silvering) on the inside to reduce heat transfer, and is used especially for storing liquified gases or for experiments at low temperatures. The size can vary from that of a small thermos bottle up to that which may be mounted upon a large truck (also known as a 'cryogenic truck').
C43191	Dialpack	Dose_Pack	Dialpack|DIALPACK|DLPK	A dose pack container designed to assist with patient compliance. The patient turns a dial to the correct day and the correct dose is made available and the container indicates that the dose has been removed.
C43192	Dose_Pack	Drug_Packaging_Device	Dose Pack|DOSE PACK|DSPK	A container in which a preselected dose or dose regimen of the medication is placed.
C43193	Packaging_Drum	Drug_Packaging_Device	Packaging Drum|DRUM	A straight-sided cylindrical shipping container with flat ends; one of which can be opened/closed.
C43194	Inhaler_Refill	Inhaler	Inhaler Refill|INHALER, REFILL|INHLRE	A container of medication intended to refill an inhaler.
C43195	Jar	Drug_Packaging_Device	Jar|JAR	A rigid container having a wide mouth and often no neck which typically holds solid or semisolid drug products.
C43196	Jug	Drug_Packaging_Device	Jug|JUG	A large, deep container that has a narrow mouth, is typically fitted with a handle, and is used to hold liquids.
C43197	Drug_Kit	Drug_Packaging_Device|Kit	Drug Kit|KIT	A package which includes a container of drug product(s) and the equipment and supplies used with it.
C43198	Combination_Package	Drug_Packaging_Device	Combination Package|PACKAGE, COMBINATION|PKGCOM	A package in which two or more drug products that are normally available separately are now available together.
C43199	Drug_Packet	Drug_Packaging_Device	Packet|PACKET|PKT	An envelope into which only one dose of a drug product, usually in the form of granules or powder, has been directly placed. An example includes glassine powder paper containing aspirin. Other examples include aluminum foil packets into which alcohol swabs and pledgets are placed.
C43200	Drug_Pouch	Drug_Packaging_Device	Pouch|POU|POUCH	A flexible container used to protect or hold one or more doses of a drug product (e.g. a pouch into which oral contraceptive blister packs are inserted, and an overwrap pouch for large volume parenterals).
C43201	Supersack	Bag	Supersack|SUPERSACK|SUPSACK	A multilayer paper bag for shipping some solid bulk excipients, usually in the form of powder or granules.
C43202	Syringe	Drug_Packaging_Device	Syringe|SYR|SYRINGE	A device for the administration of parenteral drug products that consists of a rigid barrel fitted with septum with a plunger at one end and a seal or needle at the other end. The needle assembly may be part of the device or separate.
C43203	Glass_Syringe	Syringe	Glass Syringe|SYRGL|SYRINGE, GLASS	A device for the administration of parenteral drug products that consists of a rigid glass barrel fitted with septum with a plunger at one end and a seal or needle at the other end. The needle assembly may be part of the device or separate.
C43204	Plastic_Syringe	Syringe	Plastic Syringe|SYRINGE, PLASTIC|SYRPL	A device for the administration of parenteral drug products that consists of a rigid plastic barrel fitted with septum with a plunger at one end and a seal or needle at the other end. The needle assembly may be part of the device or separate.
C43205	Tabminder	Drug_Packaging_Device	Tabminder|TABMIND|TABMINDER	A specialized package; it registers each time it is opened and is used for checking patient compliance to prescribed medication regimens.
C43206	Packaging_Tank	Drug_Packaging_Device	Packaging Tank|TANK	A large receptacle used for holding, transporting, or storing liquids or gases, and often referred to as a reservoir.
C43207	Applicator_Tube	Drug_Applicator	Applicator Tube|TUBE, WITH APPLICATOR|TUBEAP	A tube which is provided with a device (the applicator) for administering the dosage form. The applicator may be part of the tube closure or be separate.
C43208	Dispensing_Vial	Vial	Dispensing Vial|VIAL, DISPENSING|VIALDIS	A vial that is used by the pharmacist to dispense the prescribed medication.
C43209	Glass_Vial	Vial	Glass Vial|VIAL, GLASS|VIALGL	A glass container designed for use with parenteral drug products.
C43210	Multi_Dose_Vial	Vial	Multi Dose Vial|VIAL, MULTI-DOSE|VIALMD	A vial intended to contain more than one dose of the drug product.
C43211	Patent_Delivery_System_Vial	Vial	Patent Delivery System Vial|VIAL, PATENT DELIVERY SYSTEM|VIALPAT	A vial that has a patented delivery system.
C43212	Pharmacy_Bulk_Vial	Vial	Pharmacy Bulk Vial|VIAL, PHARMACY BULK PACKAGE|VIALPHR	A container of a sterile preparation whose contents are intended for use in a pharmacy admixture program and are restricted to the preparation of admixtures for infusion or, through a sterile transfer device, for the filling of empty sterile syringes.
C43213	Piggyback_Vial	Vial	Piggyback Vial|VIAL, PIGGYBACK|VIALPIG	A vial that contains a parenteral preparation that can be attached directly to the tubing of a parenterally administered fluid.
C43214	Plastic_Vial	Vial	Plastic Vial|VIAL, PLASTIC|VIALPL	A plastic container designed for use with parenteral drug products.
C43215	Single_Dose_Vial	Vial	Single Dose Vial|VIAL, SINGLE-DOSE|VIALSD	A vial containing a single unit of a parenteral drug product.
C43216	Single_Use_Vial	Vial	Single Use Vial|VIAL, SINGLE-USE|VIALSU	A vial where a single dose of a parenteral drug product can be removed, and then the vial and its remaining contents can be disposed.
C43217	Neoplastic_Erythroblast	Abnormal_Erythroblast|Neoplastic_Myeloid_Blast	Neoplastic Erythroblast
C43218	Medium_to_Large_Size_Neoplastic_Erythroblast	Neoplastic_Erythroblast	Neoplastic Medium to Large Size Erythroblast
C43219	Multipotent_Bone_Marrow_Stem_Cell_with_Wide_Myeloid_Potential	Multipotent_Bone_Marrow_Stem_Cell	Multipotent Bone Marrow Stem Cell with Wide Myeloid Potential	A specialized, self-renewing cell in the bone marrow that has the capacity to differentiate into a cell with a particular function, but especially a myeloid progenitor cell.
C43220	Primitive_Stem_Cell_with_Some_Degree_of_Commitment_to_the_Erythroid_Lineage	Bone_Marrow_Stem_Cell	Primitive Stem Cell with Some Degree of Commitment to the Erythroid Lineage
C43221	Bone_Marrow_Stem_Cell_Committed_to_the_Megakaryocytic_Lineage	Myeloid_Progenitor_Cell	Bone Marrow Stem Cell Committed to the Megakaryocytic Lineage	A primitive undifferentiated cell which can undergo division and can give rise to one of the early megakaryocytes.
C43223	Acute_Myeloid_Leukemia_Transient_Myeloproliferative_Disorder_in_Down_Syndrome	Acute_Myeloid_Leukemia_not_Otherwise_Categorized	Acute Myeloid Leukemia/Transient Myeloproliferative Disorder
C43224	Trisomy_21	Trisomy	Trisomy 21
C43225	Bone_Marrow_Stem_Cell_with_Potential_for_Megakaryocytic_and_Erythroid_Differentiation	Myeloid_Progenitor_Cell	Bone Marrow Stem Cell with Potential for Megakaryocytic and Erythroid Differentiation	An undifferentiated cell which can undergo division and can give rise to either a megakaryocyte or a cell in the erythrocytic series.
C43226	Parenteral_Vial	Vial	Parenteral Vial|VIAL	A container designed for use with parenteral drug products.
C43227	Bone_Marrow_Stem_Cell_Committed_to_the_Basophil_Lineage	Myeloid_Progenitor_Cell	Bone Marrow Stem Cell Committed to the Basophil Lineage	A primitive, undifferentiated blood cell which can undergo division and will give rise to a cell in the basophil lineage.
C43228	Rapidly_Progressive_Clinical_Course	Progressive_Clinical_Course	Rapidly Progressive Clinical Course|Rapidly Progressing Clinical Course
C43229	Primitive_Bone_Marrow_Myeloid_Stem_Cell	Myeloid_Progenitor_Cell	Primitive Bone Marrow Myeloid Stem Cell
C43230	Neoplastic_Granulocyte	Abnormal_Granulocyte|Neoplastic_Myeloid_Cell	Neoplastic Granulocyte
C43231	Mature_Neutrophils_Present	Hematopoietic_System_Finding	Mature Neutrophils Present
C43232	Neoplastic_Eosinophilic_Precursor	Neoplastic_Granulocyte	Neoplastic Eosinophilic Precursor
C43233	Package	Drug_Packaging_Device	Package|PACKAGE|PKG	The drug product container with any accompanying materials or components. This may include the protective packaging, labeling, administration devices, etc.
C43234	Not_Stated	Business_Rules	Not Stated|Not Reported
C43235	Not_Reported	Retired_Concepts	Not Reported
C43236	WAS_Gene	Regulatory_Gene	WAS Gene|IMD2|THC|WAS|WASP|Wiskott-Aldrich Syndrome (Eczema-Thrombocytopenia) Gene|Wiskott-Aldrich syndrome Gene	WAS gene encodes for Wiskott-Aldrich syndrome (WAS) family of proteins, which share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. The phenotype Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene.(from Gene)
C43237	_Xp11_4-p11_21	Chromosome_Band	Xp11.4-p11.21	A chromosome band present on Xp
C43238	Wiskott_Aldrich_Syndrome_Protein	Regulatory_Protein	Wiskott-Aldrich Syndrome Protein|IMD2|WAS|WASP|WASp	The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients. A transcript variant arising as a result of alternative promoter usage, and containing a different 5' UTR sequence, has been described, however, its full-length nature is not known. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. (From Gene, OMIM)
C43239	NP_Gene	Glycosyltransferase_Gene	NP Gene|NP|Nucleoside Phosphorylase Gene|PNP|PRO1837	NP gene encodes the enzyme purine nucleoside phosphorylase that together with adenosine deaminase (ADA) serves a key role in purine catabolism, referred to as the salvage pathway. Mutations in either enzyme result in a severe combined immunodeficiency (SCID). (from Gene)
C43241	Purine_Nucleoside_Phosphorylase	Glycosyltransferase	Purine Nucleoside Phosphorylase|EC 2.4.2.1|NP|PNP|PNP Human	The enzyme purine nucleoside phosphorylase belongs to the PNP/MTAP phosphorylase family and together with adenosine deaminase (ADA) serves a key role in purine catabolism, referred to as the salvage pathway. Defects in NP are the cause of nucleoside phosphorylase deficiency (NP deficiency). It leads to a severe T-cell immunodeficiency with neurologic disorder in children.(NCI)
C43242	Pharmaceutical_Product_Characteristics	Characteristics	Pharmaceutical Product Characteristics	The distinguishing qualities of a pharmaceutical product or substance.
C43243	Oral_Tablet_Dosage_Form	Tablet_Dosage_Form	Oral Tablet Dosage Form|Oral Tablet Dose Form	A solid dosage form for oral administration containing medicinal substances with or without appropriate diluent(s).
C43245	Pyramidal_Tract_Dysfunction	Neurological_Signs_and_Symptoms	Pyramidal Tract Dysfunction|Dysfunction of the Pyramidal Tract	Dysfunction of the corticospinal (pyramidal) tracts of the spinal cord.  Symptoms include increased muscle tone in the lower extremities, hyperreflexia, positive Babinski, and decreased fine motor coordination.
C43246	Mass_Property	Properties_or_Attributes	Mass	The amount of matter in an object.
C43247	Babinski_s_Sign	Motor_Manifestations	Babinski's Sign|Babinski's Phenomenon|Babinski's Reflex
C43248	Hyperreflexia	Motor_Manifestations	Hyperreflexia
C43249	Mature_Tissue_Histiocyte	Histiocyte	Mature Tissue Histiocyte	A macrophage found in connective tissue. It is part of the reticuloendothelial system. The primary function of a mature tissue histiocyte is to phagocytose and digest tissue fragments especially apoptotic bodies and those fragments resulting from tissue injury and death.
C43251	Histiocytic_and_Dendritic_Cell	Hematopoietic_Cell	Histiocytic and Dendritic Cell	A grouping of hematopoietic cells derived from monocytes.
C43252	Antigen_Processing_Cell	Cell	Antigen Processing Cell	A cell that enables a T-lymphocyte to recognize an antigen by engulfing the antigen, breaking down the antigen into smaller fragments which bind to MHC molecules on the surface of the antigen processing cell. The T-lymphocyte can now recognize and bind with the MHC-linked antigen.
C43253	Neoplastic_Histiocytic_and_Dendritic_Cell	Neoplastic_Hematopoietic_Cell	Neoplastic Histiocytic and Dendritic Cell
C43255	Large_Round_to_Oval_Malignant_Histiocyte	Neoplastic_Histiocyte	Large Malignant Histiocyte
C43256	Large_Multinucleated_Malignant_Histiocyte	Large_Round_to_Oval_Malignant_Histiocyte	Large Multinucleated Malignant Histiocyte
C43257	Unifocal_Disease	Localized_Disease	Unifocal Disease
C43258	Multifocal_Unisystem_Disease	Clinical_Course_of_Disease	Multifocal Unisystem Disease
C43259	Multifocal_Multisystem_Disease	Systemic_Disease	Multifocal Multisystem Disease
C43260	Bone_Lesion	Lesion	Bone Lesion
C43261	Multiple_Destructive_Bone_Lesions	Bone_Lesion	Multiple Destructive Bone Lesions
C43262	Exophthalmos	Eye_and_Ear_Finding	Exophthalmos
C43263	Diabetes_Insipidus	Non-Neoplastic_Endocrine_Disorder	Diabetes Insipidus
C43264	Monoclonal_Langerhans_Cells_Present	Clonal_Cellular_Population_Present	Monoclonal Langerhans Cells Present|Clonal Langerhans Cells Present
C43265	Ultrastructural_Finging	Finding	Ultrastructural Finding
C43266	Birbeck_Granules_Present	Ultrastructural_Finging	Birbeck Granules Present
C43267	CD1a_Positive_Neoplastic_Cells_Present	Positive_Immunophenotypic_Test_Result	CD1a-Positive Neoplastic Cells Present
C43268	HMB-45_Positive_Neoplastic_Cells_Present	Positive_Immunophenotypic_Test_Result	HMB-45-Positive Neoplastic Cells Present
C43269	CD21_Positive_Neoplastic_Cells_Present	Positive_Immunophenotypic_Test_Result	CD21-Positive Neoplastic Cells Present
C43270	CD35_Positive_Neoplastic_Cells_Present	Positive_Immunophenotypic_Test_Result	CD35-Positive Neoplastic Cells Present
C43271	Neoplastic_Dendritic_Cell	Neoplastic_Histiocytic_and_Dendritic_Cell	Neoplastic Dendritic Cell
C43273	Paracortical_Involvement_with_Residual_Follicles_Present	Morphologic_Finding	Paracortical Involvement with Residual Follicles Present
C43274	Leukemic_Mast_Cell	Leukemic_Cell|Neoplastic_Mast_Cell	Leukemic Mast Cell
C43275	Inverse_Role	Terminology_Entity	Inverse Role|Inverse Role Entity	An inverse role has the same basic meaning of a role entity but is expressed in the opposite direction.  For computational reasons these can't be directly modeled in the NCI Thesaurus but are computed after the fact.
C43276	Serum_Total_Tryptase_Levels_Increased	Abnormal_Blood_and_Hematology_Test_Result	Serum Total Tryptase Levels Increased
C43277	Pure_Cutaneous_Mastocytosis	Cutaneous_Mastocytosis	Pure Cutaneous Mastocytosis
C43278	Macular_Lesion	Integumentary_System_Signs_and_Symptoms|Lesion	Macular Lesion
C43280	Peau_Chagrine_Lesion	Integumentary_System_Signs_and_Symptoms|Lesion	Peau Chagrine Lesion|Grain Leather Skin
C43281	Mast_Cells_20_Percent_or_More_of_Bone_Marrow_Nucleated_Cells	Abnormal_Bone_Marrow_Test_Result	Mast Cells 20 Percent or More of Bone Marrow Nucleated Cells
C43282	Mast_Cells_10_Percent_or_More_of_Peripheral_Blood_White_Cells	Abnormal_Hematology_Test_Result	Mast Cells 10 Percent or More of Peripheral Blood White Cells
C43283	B-Symptoms	Hematopoietic_System_Finding|Symptom	B-Symptoms|B Symptoms	Features commonly associated with lymphoma, including fever above 38C, drenching night sweats, and weight loss of more than 10% of body mass in the previous 6 months.  B symptoms are signs of a poor prognosis in patients with lymphoma. -- 2005
C43284	Primary_Systemic_Mastocytosis	Systemic_Mastocytosis	Primary Systemic Mastocytosis
C43285	Unifocal_Disease_at_Presentation	Unifocal_Disease	Unifocal Disease at Presentation
C43286	Monoclonal_Myeloid_or_Lymphoid_Cells_Present	Clonal_Cellular_Population_Present	Monoclonal Myeloid or Lymphoid Cells Present|Clonal Myeloid or Lymphoid Cells Present
C43287	BLM_Gene_Mutation	Gene_Abnormality	BLM Gene Mutation
C43288	Precontrast	Temporal_Modifier	Precontrast	Refers to the time before a contrast agent is added in an imaging study.
C43289	WAS_Gene_Mutation	Gene_Abnormality	WAS Gene Mutation
C43290	Postcontrast	Temporal_Modifier	Postcontrast	Refers to the time after a contrast agent is added in an imaging study.
C43291	CDKN1C_Gene_Inactivation	Gene_Abnormality	CDKN1C Gene Mutation
C43292	WRN_Gene_Mutation	Gene_Abnormality	WRN Gene Mutation
C43293	RET_Gene_Mutation	Gene_Abnormality	RET Gene Mutation
C43294	KLK11_Gene	Protease_Gene	KLK11 Gene|KLK11|Kallikrein 11 Gene|MGC33060|PRSS20|TLSP	This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in two transcript variants encoding two different isoforms, which are differentially expressed. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers.(from Gene)
C43295	Hereditary_Diffuse_Gastric_Adenocarcinoma	Diffuse_Gastric_Adenocarcinoma|Familial_Cancer	Hereditary Diffuse Gastric Adenocarcinoma
C43297	Kallikrein-11_Precursor	Kallikrein	Kallikrein 11|EC 3.4.21.-|Hippostasin|KLK11|Kallikrein-Like Serine Protease|Trypsin-like protease	Kallikreins are a subgroup of serine proteases having diverse physiological functions. Possible multifunctional protease. Efficiently cleaves bz-Phe-Arg-4-methylcoumaryl-7-amide, a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin.( from Gene, Swiss_Prot)
C43298	Hereditary_Pancreatic_Carcinoma	Familial_Cancer|Pancreatic_Carcinoma	Hereditary Pancreatic Carcinoma
C43300	Campylobacter_Jejuni_Infection	Bacterial_Infection|Gastrointestinal_Infection	Campylobacter Jejuni Infection
C43301	COL1A1-PDGFbeta_Fusion_Protein_Expression	Fusion_Protein_Expression	COL1A1-PDGFbeta Fusion Protein Expression
C43302	Intracerebral	Anatomy_Modifier	Intracerebral	Of, ocurring in, or situated within the cerebrum.
C43303	t_12_19_q13_q13_3	Chromosomal_Translocation	t(12;19)(q13;q13.3)
C43304	t_13_22_q22_q13_3	Chromosomal_Translocation	t(13;22)(q22;q13.3)
C43305	Monosomy_3	Monosomy	Monosomy 3
C43306	SS18-SSX_Fusion_Protein_Expression	Fusion_Protein_Expression	SS18-SSX Fusion Protein Expression|SSXT-SSX Fusion Protein Expression|SYT-SSX Fusion Protein Expression
C43307	Neoplastic_Connective_and_Soft_Tissue_Epithelioid_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell|Neoplastic_Epithelioid_Cell	Neoplastic Connective and Soft Tissue Epithelioid Cell
C43308	t_3_8_p12_q21	Chromosomal_Translocation	t(3;8)(p12;q21)
C43309	Gain_of_Chromosome_10p	Chromosomal_Gain	Gain of Chromosome 10p
C43310	Malignant_Hair_Follicle_Neoplasm	Hair_Follicle_Neoplasm|Malignant_Skin_Appendage_Neoplasm	Malignant Hair Follicle Neoplasm|Malignant Hair Follicle Tumor
C43311	Germinative_Follicular_Epithelium_Neoplasm	Epithelial_Neoplasm|Hair_Follicle_Neoplasm	Germinative Follicular Epithelium Neoplasm|Germinative Follicular Epithelium Tumor
C43312	Mixed_Epithelial_and_Mesenchymal_Hair_Follicle_Neoplasm	Hair_Follicle_Neoplasm|Mixed_Neoplasm	Mixed Epithelial and Mesenchymal Hair Follicle Neoplasm|Mixed Epithelial and Mesenchymal Hair Follicle Tumor
C43313	Pilar-Associated_Mesenchyme_Neoplasm	Hair_Follicle_Neoplasm	Pilar-Associated Mesenchyme Neoplasm|Pilar-Associated Mesenchyme Tumor
C43314	HMOX1_Gene	Oxidoreductase_Gene	HMOX1 Gene|HMOX1|HO|HO1|Heme Oxygenase (Decycling) 1 Gene	Oriented from centromere to telomere, 5-exon human HMOX1 Gene (Heme Oxygenase Family) encodes 288 aa 33-kD conserved Heme Oxygenase 1, a microsomal enzyme (highest activity in spleen) involved in heme catabolism and highly inducible by its heme substrate, heavy metals, bromobenzene, endotoxin, oxidizing agents, and UV-A. A protective antioxidant, heme oxygenase cleaves the alpha methene bridge of the heme ring to form biliverdin (converted to bilirubin by biliverdin reductase) and carbon monoxide, a putative neurotransmitter. (NCI)
C43315	Benign_Outer_Hair_Sheath_and_Infundibulum_Neoplasm	Benign_Hair_Follicle_Neoplasm|Outer_Hair_Sheath_and_Infundibulum_Neoplasm	Benign Outer Hair Sheath and Infundibulum Neoplasm|Benign Outer Hair Sheath and Infundibulum Tumor
C43316	Malignant_Outer_Hair_Sheath_and_Infundibulum_Neoplasm	Malignant_Hair_Follicle_Neoplasm|Outer_Hair_Sheath_and_Infundibulum_Neoplasm	Malignant Outer Hair Sheath and Infundibulum Neoplasm|Malignant Outer Hair Sheath and Infundibulum Tumor
C43318	Heme_Oxygenase-1	Oxygenase	Heme Oxygenase 1|HMOX1|HO1|Heme Oxygenase (Decyclizing)	Encoded by human HMOX1 Gene (Heme Oxygenase Family), 288 aa 33-kD conserved Heme Oxygenase 1 is a microsomal enzyme (highest activity in spleen) involved in heme catabolism and highly inducible by its heme substrate, heavy metals, bromobenzene, endotoxin, oxidizing agents, and UV-A. A protective antioxidant, heme oxygenase cleaves the alpha methene bridge of the heme ring to form biliverdin (converted to bilirubin by biliverdin reductase) and carbon monoxide, a putative neurotransmitter. (NCI)
C43319	Benign_Germinative_Epithelium_Neoplasm	Benign_Hair_Follicle_Neoplasm|Germinative_Follicular_Epithelium_Neoplasm	Benign Germinative Follicular Epithelium Neoplasm|Benign Germinative Follicular Epithelium Tumor
C43320	Publication_Volume	Document_Type	Volume	A publication that is one of a set of several similar publications.
C43321	Malignant_Germinative_Follicular_Epithelium_Neoplasm	Germinative_Follicular_Epithelium_Neoplasm|Malignant_Hair_Follicle_Neoplasm	Malignant Germinative Follicular Epithelium Neoplasm|Malignant Germinative Follicular Epithelium Tumor
C43322	Benign_Mixed_Epithelial_and_Mesenchymal_Hair_Follicle_Neoplasm	Benign_Hair_Follicle_Neoplasm|Mixed_Epithelial_and_Mesenchymal_Hair_Follicle_Neoplasm	Benign Mixed Epithelial and Mesenchymal Hair Follicle Neoplasm|Benign Mixed Epithelial and Mesenchymal Hair Follicle Tumor
C43323	Benign_Pilar-Associated_Mesenchyme_Neoplasm	Benign_Hair_Follicle_Neoplasm|Pilar-Associated_Mesenchyme_Neoplasm	Benign Pilar-Associated Mesenchyme Neoplasm|Benign Pilar-Associated Mesenchyme Tumor
C43324	Outer_Hair_Sheath_and_Infundibulum_Neoplasm	Hair_Follicle_Neoplasm	Outer Hair Sheath and Infundibulum Neoplasm|Neoplasm of the Outer Hair Sheath and Infundibulum|Outer Hair Sheath and Infundibulum Tumor|Tumor of the Outer Hair Sheath and Infundibulum
C43325	Trichoadenoma	Benign_Outer_Hair_Sheath_and_Infundibulum_Neoplasm	Trichoadenoma
C43326	Trichilemmal_Carcinoma	Adnexal_Carcinoma|Malignant_Outer_Hair_Sheath_and_Infundibulum_Neoplasm	Trichilemmal Carcinoma
C43327	Malignant_Proliferating_Pilar_Tumor	Malignant_Outer_Hair_Sheath_and_Infundibulum_Neoplasm	Malignant Proliferating Pilar Tumor|Giant Hair Matrix Tumor|Malignant Pilar Tumor
C43328	Trichoepithelial_Carcinoma	Adnexal_Carcinoma|Malignant_Germinative_Follicular_Epithelium_Neoplasm	Trichoepithelial Carcinoma
C43329	Trichofollicular_Carcinoma	Adnexal_Carcinoma|Malignant_Germinative_Follicular_Epithelium_Neoplasm	Trichofollicular Carcinoma
C43331	Fibrofolliculoma	Benign_Pilar-Associated_Mesenchyme_Neoplasm	Fibrofolliculoma
C43332	Pilar_Leiomyoma	Benign_Pilar-Associated_Mesenchyme_Neoplasm|Cutaneous_Leiomyoma	Pilar Leiomyoma
C43333	Trichodiscoma	Benign_Pilar-Associated_Mesenchyme_Neoplasm	Trichodiscoma
C43334	Superficial_Epithelioma_with_Sebaceous_Differentiation	Benign_Sebaceous_Neoplasm|Epithelioma	Superficial Epithelioma with Sebaceous Differentiation
C43336	Sebaceoma	Benign_Sebaceous_Neoplasm	Sebaceoma|Infundibular Adenoma|Poroma-like Adnexal Neoplasm|Sebocrine Adenoma
C43337	Sebocyte	Glandular_Cell	Sebocyte	An epithelial cell that produces sebum, a thick, semi-fluid substance composed of fat and epithelial debris from the cells of innermost layer of the epithelium.
C43338	Neoplastic_Sebocyte	Neoplastic_Epithelial_Cell	Neoplastic Sebocyte
C43339	Malignant_Sebocyte	Malignant_Epithelial_Cell|Neoplastic_Sebocyte	Malignant Sebocyte
C43340	Ocular_Sebaceous_Carcinoma	Eye_Carcinoma|Sebaceous_Carcinoma	Ocular Sebaceous Carcinoma|Eye Sebaceous Carcinoma
C43341	Extraocular_Cutaneous_Sebaceous_Carcinoma	Sebaceous_Carcinoma	Extraocular Cutaneous Sebaceous Carcinoma
C43342	Apocrine_Hydrocystoma	Apocrine_Adenoma|Hidrocystoma	Apocrine Hidrocystoma|Apocrine Hydrocystoma
C43344	Carcinoma_ex_Eccrine_Spiradenoma	Eccrine_Adenocarcinoma|Malignant_Eccrine_Spiradenoma	Carcinoma ex Eccrine Spiradenoma
C43345	Ductal_Eccrine_Carcinoma	Eccrine_Adenocarcinoma	Ductal Eccrine Carcinoma
C43346	Ductal_Eccrine_Carcinoma_with_Spindle_Cell_Elements	Ductal_Eccrine_Carcinoma	Ductal Eccrine Carcinoma with Spindle Cell Elements
C43347	Ductal_Eccrine_Carcinoma_with_Squamous_Metaplasia	Ductal_Eccrine_Carcinoma	Ductal Eccrine Carcinoma with Squamous Metaplasia
C43349	Ductal_Eccrine_Carcinoma_with_Abundant_Fibromyxoid_Stroma	Ductal_Eccrine_Carcinoma	Ductal Eccrine Carcinoma with Abundant Fibromyxoid Stroma
C43351	Sporadic_Cylindroma	Cylindroma	Sporadic Cylindroma
C43352	Turban_Tumor	Cylindroma	Turban Tumor|Ancell-Spiegler Syndrome
C43353	Classical_Eccrine_Poroma	Benign_Eccrine_Neoplasm|Poroma_Acrospiroma	Classical Eccrine Poroma
C43354	Hidroacanthoma_Simplex	Poroma_Acrospiroma	Hidroacanthoma Simplex
C43355	Syringoacanthoma	Poroma_Acrospiroma	Syringoacanthoma
C43356	Eccrine_Syringofibroadenoma	Benign_Eccrine_Neoplasm|Sweat_Gland_Adenoma	Eccrine Syringofibroadenoma
C43357	Eccrine_Acrospiroma	Benign_Eccrine_Neoplasm	Eccrine Acrospiroma
C43358	Design	Clinical_or_Research_Activity	Design	The act of working out the form of something (as by making a sketch or outline or plan) or the result of this activity.
C43359	Group	Conceptual_Entities	Group	Any number of entities (members) considered as a unit.
C43360	Manufacture	Clinical_or_Research_Activity	Manufacture	The act of making something (a product) from raw materials.
C43361	Barcode	Code	Barcode|Bar Code	A machine-readable representation of information in a visual format on a surface.
C43362	Anus	Gastrointestinal_System_Part	Anus|anus	(AY-nus) The opening of the rectum to the outside of the body.
C43364	Anal_Margin	Skin	Anal Margin|Perianal Skin
C43366	Compound	Conceptual_Entities	Compound	A substance formed by chemical union of two or more elements or ingredients in definite proportion by weight.
C43367	Confidence	Conceptual_Entities	Confidence	A feeling of trust (in someone or something).
C43368	Editor	Miscellaneous_Occupations	Editor	A person who edits material for publication; a person having managerial and sometimes policy-making responsibility for the editorial part of a publishing firm or of a newspaper, magazine, or other publication; the supervisor or conductor of a department of a newspaper, magazine, etc.
C43369	Error	Conceptual_Entities	Error	A discrepancy between a computed, observed, or measured value or condition and the true, specified, or theoretically correct value or condition. (http://foldoc.doc.ic.ac.uk/foldoc/foldoc.cgi?error)
C43370	Glandular_Epithelium	Epithelium|Glandular_Epithelial_Tissue	Glandular Epithelium
C43371	Variable	Conceptual_Entities	Variable	Any characteristic or attribute that can be measured. (CDC)
C43372	Lentigo_Maligna	Melanoma_in_situ	Lentigo Maligna|Hutchinson's Melanotic Freckle
C43373	Eccrine_Cell	Epithelial_Cell	Eccrine Cell	A secretory cell that discharges its product without loss of cytoplasm.
C43374	Apocrine_Cell	Glandular_Cell	Apocrine Cell	A glandular secreting cell in which the apical portion of the secreting cell is cast off along with the secretory products that have accumulated therein.
C43375	HRPT2_Gene_Mutation	Gene_Abnormality	HRPT2 Gene Mutation
C43376	Biologically-Derived_Material	Miscellaneous_Molecular_Biology_Terms	Biologically-Derived Material|Biomaterial|Biospecimen	Natural substances derived from living organisms such as cells, tissues, proteins, and DNA.
C43377	Microplate	Diagnostic_Therapeutic_and_Research_Equipment	Microplate	A flat dish with multiple individual wells that are arrayed in a standardized number, size, and arrangement.
C43378	Row	Conceptual_Entities	Row	An arrangement of objects side by side in a line.
C43379	Column	Conceptual_Entities	Column	An arrangement of objects one under another in a line.
C43380	Biosequence	UML_Entity	Biosequence	A BioSequence is an object representation of a DNA, RNA, or protein sequence.  It can be represented by a Clone, Gene, or the sequence. (caMAGE)
C43381	Entry	Document_Type	Entry	An item inserted in a written or electronic record.
C43382	Signal	Conceptual_Entities	Signal	A detectable physical quantity or impulse (e.g., voltage, current, or magnetic field strength). (from Merriam Webster OnLine)
C43383	Model	Conceptual_Entities	Model	A style or design of an item.
C43384	Acquisition	Clinical_or_Research_Activity	Acquisition	The process by which something is acquired or obtained.
C43385	Image_Acquisition	Imaging_Technology	Image Acquisition	The process by which an image is acquired or obtained.
C43386	Labeled	General_Modifier	Labeled|Tagged	Bearing or marked with a label or tag.
C43387	Zinc_Finger_and_BTB_Domain_Containing_Protein_7	Transcription_Repressor_Corepressor	Zinc Finger and BTB Domain Containing Protein 7|FBI-1|Factor Binding IST Protein 1|Factor That Binds To Inducer Of Short Transcripts Protein 1|HIV-1 1st-Binding Protein 1|Leukemia/Lymphoma Related Factor|POK Erythroid Myeloid Ontogenic Factor|Pokemon|TTF-I Interacting Peptide 21|ZBTB7	Encoded by ZBTB7 gene, Zinc Finger and BTB Domain Containing Protein 7 or leukemia/lymphoma-related factor is a 584-amino acid protein containing 4 C-terminal Kruppel-type zinc fingers, a bipartite nuclear localization signal, and an N-terminal POZ domain.  It is also known as Pokemon (POK Erythroid Myeloid ONtogenic factor), which belongs to the POK family (POZ domain and Kruppel zinc fingers) of transcriptional factors. If mutated, they become transcriptional repressors through the engagement of histone deacetylases, causing chromatin remodeling and in turn tumorigenesis.  Pokemon functions as a proto-oncogene via direct binding and repress the expression of the tumor suppressor ARF.  It also play a role in cellular differentiation and physically interact with other members of the POK family. (NCI)
C43388	ZBTB7_Gene	Transcription_Corepressor_Gene	ZBTB7A Gene|FBI-1|FBI1|Factor That Binds To IST Gene|LRF|Leukemia/Lymphoma-Related Factor Gene|POK|ZBT7|ZBTB7 Gene|ZBTB7A|Zinc Finger and BTB Domain Containing 7A Gene	ZBTB7 gene encodes a transcription repressor, leukemia/lymphoma-related factor or Zinc Finger and BTB Domain Containing Protein 7.  It belongs to the POK (POZ domain and Kruppel zinc fingers) gene family that encodes proteins which turn off gene expression.  The gene product is implicated in adipogenesis, cell proliferation, and oncogenesis.  It was mapped to 19p13.3 by FISH. (NCI)
C43389	Aleutian	Unangan_Aleut	Aleutian	Aleutian - a person having origins from the Aleut indigenous group of Alaska and their descendants and who maintains tribal affiliation, or community or cultural attachment.
C43390	Eskimo	Alaska_Native	Eskimo	Eskimo- a person having origins from the Eskimo indigenous group of Alaska and their descendants and who maintains tribal affiliation, or community or cultural attachment.
C43391	Chinese	Asian	Chinese	A person having origins in any of the original peoples of China.
C43392	Japanese	Asian	Japanese	A person having origins in any of the original peoples of Japan.
C43393	Filipino	Asian	Filipino	A person having origins in the Philippine Islands.
C43394	Hawaiian	Polynesian	Hawaiian|Native Hawaiian	A person having origins in any of the original peoples of Hawaii.
C43395	Korean	Asian	Korean	A person having origins in any of the original peoples of Korea.
C43396	Vietnamese	Asian	Vietnamese	A person having origins in any of the original peoples of Vietnam.
C43397	Laotian	Asian	Laotian	A person having origins in any of the original peoples of Laos.
C43398	Hmong	Asian	Hmong	A person having origins in any of the original Hmong people originating in China around the Yellow River or Hoang Ho.  Early in the 19th century, the Hmong migrated to French Indochina, which comprised Vietnam, Cambodia and Laos.  In 1947, Hmong officially became citizens of Loas.  Later a number of Hmong emigrated to Thailand and the United States.
C43399	Kampuchean	Asian	Cambodian|Kampuchean	A person from Cambodia (formerly Kampuchea) or of that ancestry.
C43400	Thai	Asian	Thai	A person having origins in any of the original peoples of Thailand.
C43402	Micronesian	Native_Hawaiian_or_Other_Pacific_Islander	Micronesian	A person from any of the islands in the western pacific encompassing the area from the Philippines in the west, Indonesia to the south west, Papua New Guinea and Melanesia to the south, and Polynesia to the south-east and east.
C43403	Chamorran	Guamanian_or_Chamorro	Chamorran|Chamorro	Any of the indigenous Chamorro people of Guam and the Mariana Islands or persons of that ancestry.
C43404	Guamanian	Guamanian_or_Chamorro	Guamanian	A person from Guam or of that ancestry.
C43405	Polynesian	Native_Hawaiian_or_Other_Pacific_Islander	Polynesian	A person from any of the over 1,000 islands in the central and southern Pacific Ocean bounded by a triangle with its three corners at Hawaii, New Zealand, and Easter Island or a person of that ancestry.
C43406	Tahitian	Polynesian	Tahitian	A person from Tahiti or of that ancestry.
C43407	Samoan	Polynesian	Samoan	A person from Samoa or of that ancestry.
C43408	Tongan	Polynesian	Tongan	A person from Tonga or of that ancestry.
C43409	Melanesian	Native_Hawaiian_or_Other_Pacific_Islander	Melanesian	A person from any of the islands in the region extending from the west Pacific to the Arafura Sea, north and north-east of Australia. or of that ancestry.
C43410	Fiji_Islander	Melanesian	Fiji Islander|Fijian	A person from Fiji or of that ancestry.
C43411	New_Guinean	Melanesian	New Guinean|Papua New Guinean	A person from Papua New Guinea or of that ancestry.
C43412	Biosample	UML_Entity	Biosample	BioSamples are products of treatments that are of interest.  BioSamples are often used as the sources for other biosamples.  The Type attribute describes the role the BioSample holds in the treatment hierarchy.  This type can be an extract. (caMAGE)
C43413	Toll-Free_Telephone_Number	Telephone_Number	Toll-Free Telephone Number|Toll-Free Number|Toll-Free Phone|Toll-Free Phone Number	A toll-free telephone number is a special telephone number in which the calling party is not charged for the cost of the call. Instead, the called party pays all of the charges for the call.
C43414	Tolerance_Value	Conceptual_Entities	Tolerance	The allowable deviation from a standard; a permissible difference.
C43415	Publication_Issue	Document_Type	Issue	One of a series of documents that are published periodically.
C43416	Publisher	Miscellaneous_Occupations	Publisher	A person or firm engaged in publishing periodicals or books or music.
C43417	Creation	Clinical_or_Research_Activity	Creation	The process by which something is brought into existence.
C43418	Cluster	Conceptual_Entities	Cluster	A grouping of a number of similar things.
C43419	Multipotent_Stem_Cell	Stem_Cell	Multipotent Stem Cell	A cell that can only differentiate to a particular type of cells (e.g. hematopoietic cells or epithelial cells). --2005
C43420	Adult_Stem_Cell	Stem_Cell	Adult Stem Cell	Mostly multipotent undifferentiated stem cells found in a specific tissue admixed with differentiated cells. --2005
C43422	Epithelial_Stem_Cell	Stem_Cell	Epithelial Stem Cell
C43423	Mesenchymal_Stem_Cell	Stem_Cell	Mesenchymal Stem Cell
C43424	Umbilical_Cord_Blood_Stem_Cell	Stem_Cell	Umbilical Cord Blood Stem Cell	A stem cell obtained from the umbilical cord. --2005
C43425	Wolffian_Duct_Cell	Embryonic_Cell	Wolffian Duct Cell	A cell of the embryonic mesonephric duct. This duct connects the primitive kidney and urogenital sinus. In the presence of testosterone, it develops into the sperm collecting apparatus - epididymis, the vas deferens, and seminal vesicles. Without testosterone, it becomes vestigial.
C43426	Tuple	Conceptual_Entities	Tuple	A data object containing two or more components.
C43427	Pakistani	South_Asian	Pakistani	This primarily refers to a person having origins in the original peoples of the Indian sub-continent, a subset of which formed Pakistan.  The term also refers to a person from Pakistan, whether or not ancestors were from India.
C43428	Zone	Conceptual_Entities	Zone	An area or region distinguished from adjacent parts by a distinctive feature or characteristic.
C43429	Defect	Conceptual_Entities	Defect	A failing or deficiency.
C43430	Layout	Conceptual_Entities	Layout	A plan or design of something that is laid out.
C43431	Activity	Conceptual_Entities	Activity	The state of being active; any specific activity.
C43432	List	Document_Type	List	A series of names, words, or other items written, printed, or imagined one after the other. (Bartleby.com)
C43433	Map	Document_Type	Map	A usually 2-dimensional diagrammatic representation of an object or area.
C43434	Functional_Map	Conceptual_Entities	Functional Map|Map|Map Function	A function such that for every element of one set there is a unique element of another set.
C43435	Composite_Sequence	UML_Entity	Composite Sequence	A collection of Reporter or CompositeSequence Design Elements, annotated through the association to BioSequence. (caMAGE)
C43436	Composite_Group	UML_Entity	Composite Group	Allows specification of the type of Composite Design Element. (caMAGE)
C43437	Composite_Position	UML_Entity	Composite Position	The location in the compositeSequence target's sequence to which a source compositeSequence maps.  The association to MismatchInformation allows the specification, usually for control purposes, of deviations from the CompositeSequence's BioMaterial. (caMAGE)
C43438	Composite_Sequence_Dimension	UML_Entity	Composite Sequence Dimension	Specialized DesignElementDimension to hold CompositeSequences. (caMAGE)
C43439	New_England_States	Geographic_Area	New England States|New England	The area in the United States comprised of the following states: Maine, New Hampshire, Vermont, Massachusetts, Rhode Island, Connecticut, and New Jersey. (from SEERS 2004 codeset)
C43440	North_Mid_Atlantic_States	Geographic_Area	North Mid-Atlantic States	The area in the United States comprised of the following states: New York, Pennsylvania and Delaware.  (from SEERS 2004 codeset)
C43441	South_Mid_Atlantic_States	Geographic_Area	South Mid-Atlantic States	The area in the United States comprised of the District of Columbia and the following states: Maryland, Virginia, West Virginia, North Carolina and South Carolina.  (from SEERS 2004 codeset)
C43442	Biomaterial_Treatment	UML_Entity	Biomaterial Treatment|Treatment	The process by which a biomaterial is created (from source biomaterials).  Treatments have an order and an action. (caMAGE)
C43443	Describable_Class	UML_Entity	Describable Class|Describable	Abstract class that allows subclasses to inherit the association to Description, for detailed annotations such as Ontology entries and Database references, the association to Audit, for tracking changes, and the association to Security for indicating permissions. (caMAGE)
C43445	Design_Element	UML_Entity	Design Element	An element of an array.  This is generally of type feature but can be specified as reporters or compositeSequence for arrays that are abstracted from a physical array. (caMAGE)
C43446	Container_Object	UML_Entity	Container Object|Collection|Collection Object|Container	An object that holds the values or locations of other objects.
C43447	Quantitation_Type	UML_Entity	Quantitation Type	A method for calculating a single datum of the matrix (e.g. raw intensity, background, error). (caMAGE)
C43448	Southeastern_States	Geographic_Area	Southeastern States	The area in the United States comprised of the following states: Tennessee, Georgia, Florida, Alabama and Mississippi. (from SEERS 2004 codeset)
C43449	North_Central_States	Geographic_Area	North Central States	The area in the United States comprised of the following states: Michigan, Ohio, Indiana, Kentucky.  (from SEERS 2004 codeset)
C43450	Northern_Midwest_States	Geographic_Area	Northern Midwest States	The area in the United States comprised of the following states: Wisconsin, Minnesota, Iowa, North Dakota, South Dakota, Montana.  (from SEERS 2004 codeset)
C43451	Extended_Release_Bead_Implant_Dosage_Form	Bead_Dosage_Form|Implant_Dosage_Form	Extended Release Bead Implant Dosage Form|BEAD IMP ER|BEAD, IMPLANT, EXTENDED RELEASE|Extended Release Bead Implant Dose Form|Extended Release Implant Bead|Extended Release Implant Bead Dosage Form	A small sterile solid mass consisting of a highly purified drug intended for implantation in the body which would allow at least a reduction in dosing frequency as compared to that drug presented as a conventional dosage form.
C43452	Southern_Midwest_States	Geographic_Area	Southern Midwest States	The area in the United States comprised of the following states: Arkansas, Louisiana, Oklahoma and Texas. (from SEERS 2004 codeset)
C43453	Central_Midwest_States	Geographic_Area	Central Midwest States	The area in the United States comprised of the following states: Illinois, Missouri, Kansas and Nebraska. (from SEERS 2004 codeset)
C43454	Mountain_States	Geographic_Area	Mountain States	The area in the United States comprised of the following states: Idaho, Wyoming, Colorado, Utah, Nevada, New Mexico and Arizona (from SEERS 2004 codeset.)
C43455	Pacific_Coast_States	Geographic_Area	Pacific Coast States	The area in the United States comprised of the following states: Alaska, Washington, Oregon, California and Hawaii (from SEERS 2004 codeset.)
C43456	District_of_Columbia	Geographic_Area	District of Columbia|D.C.|DC	The area in the United States comprised of a 68 square mile area northeast of the Potomac River donated by the state of Maryland.  The District of Columbia, also known as D.C., is not a state, nor is it part of any state.  It is a "federal district" established by the US Constitution as the seat of government. The district is occupied entirely by the city of Washington. (from SEERS 2004 codeset.)
C43457	Maine	US_State	Maine|ME	A state in the northeastern United States. Its capital is Augusta.
C43458	Cloning_Site	DNA_Sequence	Cloning Site|Insert Site|Insertion Site	The specific restriction enzyme site within a vector into which an insert was placed.
C43459	Scientific_Name	Name_Generic_Concept	Scientific Name	The name applied to a plant, animal, or other organism, according to the Codes of Nomenclature, consisting of a Genus and species.
C43460	New_Hampshire	US_State	New Hampshire|NH	A state in the northeastern United States. Its capital is Concord.
C43461	Common	General_Modifier	Common	Widely known or encountered.
C43462	Vermont	US_State	Vermont|VT	A state in the northeastern United States. Its capital is Montpelier.
C43463	Massachusetts	US_State	Massachusetts|MA	A state in the northeast United States. Its capital is Boston.
C43464	Rhode_Island	US_State	Rhode Island|RI	A state in the northeastern United States. Its capital is Providence.
C43465	Sequence_Object	Retired_Concepts	Sequence Object|Sequence	An object representation of a gene sequence; provides access to the clones from which it was derived, the ASCII representation of the residues it contains, and the sequence ID.
C43466	Connecticut	US_State	Connecticut|CT	A state in the northeastern United States. Its capital is Hartford.
C43467	New_Jersey	US_State	New Jersey|NJ	A state in the mid-atlantic United States. Its capital is Trenton.
C43468	New_York	US_State	New York|NY	A state in the northeastern United States. Its capital is Albany.
C43469	Pennsylvania	US_State	Pennsylvania|PA	A state in the mid-atlantic United States. Its capital is Harrisburg.
C43470	Delaware	US_State	Delaware|DE	A state in the mid-atlantic United States. Its capital is Dover.
C43471	Maryland	US_State	Maryland|MD	A state in the mid-atlantic United States. Its capital is Annapolis.
C43472	Virginia	US_State	Virginia|VA	A state in the mid-atlantic United States. Its capital is Richmond.
C43473	West_Virginia	US_State	West Virginia|WV	A state in the mid-atlantic United States. Its capital is Charleston.
C43474	North_Carolina	US_State	North Carolina|NC	A state in the mid-atlantic United States. Its capital is Raleigh.
C43475	South_Carolina	US_State	South Carolina|SC	A state in the mid-atlantic United States. Its capital is Columbia.
C43476	Tennessee	US_State	Tennessee|TN	A state in the southeastern United States. Its capital is Nashville.
C43477	Georgia_US_State_of	US_State	Georgia|GA|Georgia US State of	A state in the southeastern United States. Its capital is Atlanta.
C43478	Florida	US_State	Florida|FL	A state in the southeastern United States. Its capital isTallahassee.
C43479	Alabama	US_State	Alabama|AL	A state in the southeast United States. Its capital is Montgomery.
C43480	Mississippi	US_State	Mississippi|MS	A state in the southeastern United States. Its capital is Jackson.
C43481	Michigan	US_State	Michigan|MI	A state in the north central United States. Its capital is Lansing.
C43482	Ohio	US_State	Ohio|OH	A state in the north central United States. Its capital is Columbus.
C43483	Indiana	US_State	Indiana|IN	A state in the north central United States. Its capital is Indianapolis.
C43484	Kentucky	US_State	Kentucky|KY	A state in the north central United States. Its capital is Frankfort.
C43485	Wisconsin	US_State	Wisconsin|WI	A state in the northern midwest United States. Its capital is Madison.
C43486	Minnesota	US_State	Minnesota|MN	A state in the northern midwest United States. Its capital is St. Paul.
C43487	Iowa	US_State	Iowa|IA	A state in the northern midwest United States. Its capital is Des Moines.
C43488	North_Dakota	US_State	North Dakota|ND	A state in the northern midwest United States. Its capital is Bismarck.
C43489	South_Dakota	US_State	South Dakota|SD	A state in the northern midwest United States. Its capital is Pierre.
C43490	Montana	US_State	Montana|MT	A state in the northern midwest United States. Its capital is Helena.
C43491	Illinois	US_State	Illinois|IL	A state in the central midwest United States. Its capital is Springfield.
C43492	Missouri	US_State	Missouri|MO	A state in the central midwest United States. Its capital is Jefferson City.
C43493	Kansas	US_State	Kansas|KS	A state in the central midwest United States. Its capital is Topeka.
C43494	Nebraska	US_State	Nebraska|NE	A state in the central midwest United States. Its capital is Lincoln.
C43495	Arkansas	US_State	Arkansas|AR	A state in the southern midwest United States. Its capital is Little Rock.
C43496	Louisiana	US_State	Louisiana|LA	A state in the southern midwest United States. Its capital is Baton Rouge.
C43497	Oklahoma	US_State	Oklahoma|OK	A state in the southern midwest United States. Its capital is Oklahoma City.
C43498	Texas	US_State	Texas|TX	A state in the southern midwest United States. Its capital is Austin.
C43499	Idaho	US_State	Idaho|ID	A state in the northern Rocky Mountains of western United States. Its capital is Boise.
C43500	Wyoming	US_State	Wyoming|WY	A state in the western United States. Its capital is Cheyenne.
C43501	Colorado	US_State	Colorado|CO	A state in the Rocky Mountains of western United States. Its capital is Denver.
C43502	Utah	US_State	Utah|UT	A state in the western United States. Its capital is Salt Lake City.
C43503	Nevada	US_State	Nevada|NV	A state in the western United States. Its capital is Carson City.
C43504	New_Mexico	US_State	New Mexico|NM	A state in the southwestern United States. Its capital is Santa Fe.
C43505	Arizona	US_State	Arizona|AZ	A state in the southwestern United States. Its capital is Phoenix.
C43506	Alaska	US_State	Alaska|AK	A state in the far northwestern United States. Its capital is Juneau.
C43507	Washington	US_State	Washington|WA|Washington state	A state in the northwest United States. Its capital is Olympia.
C43508	Oregon	US_State	Oregon|OR	A state in the northwestern United States. Its capital is Salem.
C43509	California	US_State	California|CA	A state on the western coast of the United States. Its capital is Sacramento.
C43510	Hawaii	US_State	Hawaii|HI	A pacific island state in the United States. Its capital is Honolulu.
C43511	Organ_Relationship_Object	UML_Entity	Organ Relationship Object|Organ Relationship	An organ relationship object describes relationships among organs. (caBIO)
C43513	Keyword	Conceptual_Entities	Keyword	A small set of words designed to convey the subject of a technical article.
C43514	Disease_Relationship_Object	UML_Entity	Disease Relationship Object|Disease Relationship	The diseaser relationship specifies the relationship among diseases. (caBIO)
C43515	NCI_Enterprise_Vocabulary_Services	Information_Resources	NCI Enterprise Vocabulary Services|EVS|Enterprise Vocabulary Services|Enterprise Vocabulary System|NCI EVS	The NCI EVS is set of services and resources that address NCI's needs for controlled vocabulary. The EVS Project is a collaborative effort of the Center for Bioinformatics and the NCI Office of Communications. The NCI Thesaurus, which is a biomedical thesaurus created specifically to meet the needs of the NCI, is produced by the NCI EVS project. The NCI Thesaurus is provided under an open content license.  The EVS Project also produces the NCI Metathesaurus, which is based on NLM's Unified Medical Language System Metathesaurus supplemented with additional cancer-centric vocabulary. In addition the EVS Project provides NCI with licenses for MedDRA, SNOMED, ICD-O-3, and other proprietary vocabularies. (http://ncicb.nci.nih.gov/core/EVS)
C43516	NCI_Concept_Code	Concept_Unique_Identifier	NCI Concept Code|Concept Code|NCI Code|NCI Thesaurus Code	A concept unique identifier within the NCI Enterprise Vocabulary Service's NCI Thesaurus.
C43517	Lowest	General_Modifier	Lowest|Nadir	In the lowest position, nearest the ground, at the bottom; minimal in magnitude, lowest in rank or importance; an extreme state of adversity.
C43518	Expression_Experiment_Object	UML_Entity	Expression Experiment Object|Expression Experiment	This class encapsulates the properties of an NCICB caBIO ExpressionExperiment object. (caMAGE)
C43519	Online_Mendelian_Inheritance_in_Man	Information_Resources	Online Mendelian Inheritance in Man|OMIM	This database is a catalog of human genes and genetic disorders authored and edited by Dr. Victor A. McKusick and his colleagues at Johns Hopkins and elsewhere, and developed for the World Wide Web by NCBI, the National Center for Biotechnology Information. The database contains textual information and references. It also contains copious links to MEDLINE and sequence records in the Entrez system, and links to additional related resources at NCBI and elsewhere. (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM)
C43520	Gene_Ontology	Information_Resources	Gene Ontology|GO|GO Ontology	The Gene Ontology (GO) project is a collaborative effort to address the need for consistent descriptions of gene products in different databases.  The goal of the Gene Ontology project is to produce a controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms, molecular function, biological process, and cellular component, to describe gene product attributes. (from http://www.geneontology.org/)
C43521	Molecular_Weight	Weight	Molecular Weight|Mass|Molecular Mass	The molecular mass of a substance is the sum of the relative atomic masses of the constituent atoms of a molecule.
C43522	Checksum	Value	Checksum	A computed value which depends on the contents of a block of data and which is transmitted or stored along with the data in order to detect corruption of the data. The receiving system recomputes the checksum based upon the received data and compares this value with the one sent with the data. If the two values are the same, the receiver has some confidence that the data was received correctly. (Free On-Line Dictionary of Computing)
C43523	Probe	Nucleic_Acids	Probe	General term for a piece of DNA or RNA corresponding to a gene or sequence of interest, that has been labelled either radioactively or with some other detectable molecule, such as biotin, digoxygenin or fluorescein. As stretches of DNA or RNA with complementary sequences will (hybridize), a probe will label viral plaques, bacterial colonies or bands on a gel that contain the gene of interest. (On-line Medical Dictionary)
C43524	Brief_Symptom_Inventory_18	Symptom_Specific_Assessment_Tool	Brief Symptom Inventory 18|BSI 18	The Brief Symptom Inventory 18 (BSI 18) assessment gathers patient-reported data to help measure psychological distress and psychiatric disorders in medical and community populations. (http://www.pearsonassessments.com)
C43525	Disc_Dosage_Form	Solid_Dosage_Form	Disc Dosage Form|DISC|Disc Dose Form	A circular plate-like organ or structure.
C43526	Pyloric_Gland_Adenoma	Gastric_Intraepithelial_Neoplasia	Pyloric Gland Adenoma
C43527	Sporadic_Gastric_Carcinoma	Gastric_Adenocarcinoma	Sporadic Gastric Adenocarcinoma
C43528	Vocabulary_Object	Information_Sciences	Vocabulary|Vocabulary Object	A listing of the words used in some enterprise.
C43529	Sporadic_Diffuse_Gastric_Adenocarcinoma	Diffuse_Gastric_Adenocarcinoma|Sporadic_Gastric_Carcinoma	Sporadic Diffuse Gastric Adenocarcinoma
C43530	Supplier	Miscellaneous_Occupations	Supplier	Someone whose business is to supply a particular service or commodity.
C43531	Developmental_Stage	Developmental_Process	Developmental Stage	A general term that usually refers to named landmark events during development of an organism.
C43532	c-met_Gene_Amplification	MET_Gene_Mutation	c-met Gene Amplification
C43534	Small_Intestinal_Squamous_Cell_Carcinoma	Small_Intestinal_Carcinoma|Squamous_Cell_Carcinoma	Small Intestinal Squamous Cell Carcinoma
C43535	Small_Intestinal_Adenosquamous_Carcinoma	Adenosquamous_Carcinoma|Small_Intestinal_Carcinoma	Small Intestinal Adenosquamous Carcinoma
C43536	Small_Intestinal_Mucinous_Adenocarcinoma	Mucinous_Adenocarcinoma|Small_Intestinal_Adenocarcinoma	Small Intestinal Mucinous Adenocarcinoma
C43537	Small_Intestinal_Medullary_Carcinoma	Medullary_Carcinoma|Small_Intestinal_Carcinoma	Small Intestinal Medullary Carcinoma
C43538	Small_Intestinal_Undifferentiated_Carcinoma	Small_Intestinal_Carcinoma|Undifferentiated_Carcinoma	Small Intestinal Undifferentiated Carcinoma
C43539	Pituitary_Tumor_Transforming_Gene_Overexpression	Oncogene_Deregulation	Pituitary Tumor Transforming Gene Overexpression|PTTG Overexpression|Securin Overexpression
C43541	Pituitary_Gland_Microadenoma	Pituitary_Gland_Adenoma	Pituitary Gland Microadenoma	A pituitary gland adenoma with a diameter equal or less than 10 mm. (NCI05)
C43542	Pituitary_Gland_Macroadenoma	Pituitary_Gland_Adenoma	Pituitary Gland Macroadenoma	A pituitary gland adenoma with a diameter greater than 10 mm.  Clinical manifestations include headache, visual field disturbances, pituitary insufficiency, and mild hyperprolactinemia. (NCI05)
C43543	Small_Intestinal_Signet_Ring_Cell_Carcinoma	Signet_Ring_Cell_Carcinoma|Small_Intestinal_Adenocarcinoma	Small Intestinal Signet Ring Cell Carcinoma
C43545	Bioelectric_Impedance_Analysis	Techniques	Bioelectric Impedance Analysis|BIA|Bioelectric Impedance Test|Bioelectrical Impedance Analysis|Bioimpedance Analysis	Bioelectric impedance analysis is a method to assess body composition, i.e., the relative percentages of body weight comprised of fat and fat-free body tissue.  It is based on the principle that the resistance to an applied electric current is inversely related to the amount of fat-free mass within the body.
C43546	Appendix_Tubular_Adenoma	Appendix_Adenoma|Tubular_Adenoma	Appendix Tubular Adenoma
C43547	Appendix_Tubulovillous_Adenoma	Appendix_Adenoma|Tubulovillous_Adenoma	Appendix Tubulovillous Adenoma
C43548	Reactance	Properties_or_Attributes	Reactance|Inductive Resistance	An opposition to the flow of electric current resulting from inductance and capacitance (rather than resistance).
C43549	Appendix_Serrated_Adenoma	Appendix_Adenoma|Serrated_Adenoma	Appendix Serrated Adenoma
C43550	Appendix_Adenoma	Appendix_Neoplasm|Gastrointestinal_Adenoma	Appendix Adenoma
C43551	Small_Intestinal_Villous_Adenoma	Small_Intestinal_Adenoma|Villous_Adenoma	Small Intestinal Villous Adenoma
C43552	Small_Intestinal_Tubular_Adenoma	Small_Intestinal_Adenoma|Tubular_Adenoma	Small Intestinal Tubular Adenoma
C43553	Small_Intestinal_Tubulovillous_Adenoma	Small_Intestinal_Adenoma|Tubulovillous_Adenoma	Small Intestinal Tubulovillous Adenoma
C43554	Appendix_Signet_Ring_Cell_Carcinoma	Appendix_Adenocarcinoma|Signet_Ring_Cell_Carcinoma	Appendix Signet Ring Cell Carcinoma
C43555	Appendix_Small_Cell_Carcinoma	Appendix_Carcinoma|Small_Cell_Carcinoma	Appendix Small Cell Carcinoma
C43556	Appendix_Undifferentiated_Carcinoma	Appendix_Carcinoma|Undifferentiated_Carcinoma	Appendix Undifferentiated Carcinoma
C43557	International_Medical_Terminology	Information_Resources	International Medical Terminology|IMT	The International Medical Terminology is a clinically validated standard terminology for the reporting of regulatory activities, originally based upon the Medical Dictionary for Drug Regulatory Affairs (MedDRA), developed under the auspices of the International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH).
C43558	Appendix_Mucinous_Adenocarcinoma	Appendix_Adenocarcinoma|Mucinous_Adenocarcinoma	Appendix Mucinous Adenocarcinoma
C43559	Diagram	Document_Type	Diagram	A drawing intended to explain how something works; a drawing showing the relation between the parts.
C43560	Organ_Relationship	Retired_Concepts	Organ Relationship|OrganRelationship	An organ relationship object describes relationships among organs. (caBIO)
C43563	UniGene	Information_Resources	UniGene	An experimental system for automatically partitioning GenBank sequences into a non-redundant set of gene-oriented clusters. Each UniGene cluster contains sequences that represent a unique gene, as well as related information such as the tissue types in which the gene has been expressed and map location.  It is provided as a web application from the National Center for Biotechnology Information (NCBI).
C43564	Appendix_Mixed_Endocrine-Exocrine_Neoplasm	Combined_Carcinoid_and_Adenocarcinoma|Malignant_Appendix_Neoplasm	Appendix Mixed Endocrine-Exocrine Neoplasm
C43565	Appendix_Tubular_Carcinoid	Appendix_Mixed_Endocrine-Exocrine_Neoplasm	Appendix Tubular Carcinoid Tumor|Appendix Tubular Carcinoid
C43566	Gross	General_Modifier	Gross|Macroscopic	Visible to the naked eye.
C43567	GO_Ontology_Relationship	UML_Entity	GO Ontology Relationship	This object specifies GoOntologyrRelationship. (caBIO)
C43568	Gene_Symbol	Identifier	Gene Symbol|Official Gene Name	A unique gene name approved by an organism specific nomenclature committee.
C43569	HRPT2_Gene	Gene_with_Unknown_or_Unclassified_Function	HRPT2 Gene|C1orf28|FLJ23316|HPT-JT|Hyperparathyroidism 2 (with Jaw Tumor) Gene|parafibromin Gene	HRPT2 is a putative tumor suppressor gene, which consists of 17 exons, all of which are coding. Inactivation of HRPT2 gene is directly involved in predisposition to HPT-JT and in development of some sporadic parathyroid tumors. A single locus associated with hyperparathyroidism-2 had been mapped to a 15-cM region within 1q24-q32. This region was further refined to a critical interval of 12 cM, by genotyping in 26 affected kindreds and HRPT2 gene was identified using a positional candidate approach. The HRPT2 open reading frame of 1,596 nucleotides encodes a protein of 531 amino acids. Northern blot analysis detected a 2.7-kb transcript expressed at varying levels in all tissues examined. HRPT2 and its encoded protein, parafibromin, are evolutionarily conserved; human parafibromin shares 54% and 25% identity with the D. melanogaster and C. elegans orthologs, respectively. (from OMIM, and NCI)
C43570	Object_Relationship	UML_Entity	Object Relationship|Relationship	How objects are related to other objects.
C43571	Disease_Object	UML_Entity	Disease Object|Disease Vocabulary	Disease objects specify a disease name and ID; disease objects also provide access to: ontological relations to other diseases; clinical trial protocols treating the disease; and specific histologies associated with instances of the disease. (caBIO)
C43572	Parafibromin	Protein_with_Unknown_or_Unclassified_Function	Parafibromin|HRPT2|Hyperparathyroidism 2 protein	Parafibromin is the 531-amino-acid protein product of HRPT2 Gene. The protein is evolutionarily conserved. Human parafibromin shares 54% and 25% identity with the D. melanogaster and C. elegans orthologs, respectively.(from NCI and OMIM)
C43573	Glandular_Differentiation	Epithelial_Differentiation	Glandular Differentiation
C43574	Neuroendocrine_Differentiation	Epithelial_Differentiation	Neuroendocrine Differentiation
C43576	Appendix_Lipoma	Benign_Appendix_Neoplasm|Lipoma	Appendix Lipoma
C43577	Colon_Serrated_Adenoma	Colonic_Adenoma|Colorectal_Serrated_Adenoma	Colon Serrated Adenoma
C43578	Flag	UML_Entity	Flag	An indicator that can be set or unset in order to signal whether a particular condition is true.
C43579	Universal_Protein_Resource	Information_Resources	Universal Protein Resource|UniProt	UniProt (Universal Protein Resource) is the world's most comprehensive catalog of information on proteins. It is a central repository of protein sequence and function created by joining the information contained in Swiss-Prot, TrEMBL, and PIR.  The UniProt Knowledgebase (UniProt) is the central access point for extensive curated protein information, including function, classification, and cross-reference.  (http://www.pir.uniprot.org/)
C43580	Protein_Families_Database	Information_Resources	Protein Families Database|Pfam	Pfam is a large collection of multiple sequence alignments and hidden Markov models covering many common protein domains and families. For each family in Pfam you can 1) look at multiple alignments; 2) view protein domain architectures; 3) examine species distribution; 4) follow links to other databases; and 5) view known protein structures. (http://www.sanger.ac.uk/Software/Pfam/)
C43581	Provenance	Conceptual_Entities	Provenance	Where something originated or was nurtured in its early existence.
C43582	Data_Transformation	Clinical_or_Research_Activity	Data Transformation|Transformation	A process whereby data is changed from one format to another.
C43583	Evidence	Conceptual_Entities	Evidence	Knowledge on which to base belief.
C43584	Rectosigmoid_Adenocarcinoma	Colorectal_Adenocarcinoma|Rectosigmoid_Carcinoma	Rectosigmoid Adenocarcinoma
C43585	Colorectal_Mucinous_Adenocarcinoma	Colorectal_Adenocarcinoma|Mucinous_Adenocarcinoma	Colorectal Mucinous Adenocarcinoma
C43586	Colorectal_Signet_Ring_Cell_Carcinoma	Colorectal_Adenocarcinoma|Signet_Ring_Cell_Carcinoma	Colorectal Signet Ring Cell Carcinoma
C43587	Colorectal_Small_Cell_Carcinoma	Colorectal_Carcinoma|Small_Cell_Carcinoma	Colorectal Small Cell Carcinoma
C43588	Colorectal_Squamous_Cell_Carcinoma	Colorectal_Carcinoma|Squamous_Cell_Carcinoma	Colorectal Squamous Cell Carcinoma
C43589	Colorectal_Adenosquamous_Carcinoma	Adenosquamous_Carcinoma|Colorectal_Carcinoma	Colorectal Adenosquamous Carcinoma
C43590	Colorectal_Medullary_Carcinoma	Colorectal_Carcinoma|Medullary_Carcinoma	Colorectal Medullary Carcinoma
C43591	Colorectal_Undifferentiated_Carcinoma	Colorectal_Carcinoma|Undifferentiated_Carcinoma	Colorectal Undifferentiated Carcinoma
C43592	Rectosigmoid_Mucinous_Adenocarcinoma	Colorectal_Mucinous_Adenocarcinoma|Rectosigmoid_Adenocarcinoma	Rectosigmoid Mucinous Adenocarcinoma
C43593	Rectosigmoid_Signet_Ring_Cell_Carcinoma	Colorectal_Signet_Ring_Cell_Carcinoma|Rectosigmoid_Adenocarcinoma	Rectosigmoid Signet Ring Cell Carcinoma
C43594	Rectal_Adenosquamous_Carcinoma	Colorectal_Adenosquamous_Carcinoma|Rectal_Carcinoma	Rectal Adenosquamous Carcinoma
C43595	Mammary	Anatomy_Modifier	Mammary|mammary	Having to do with the breast.
C43596	Protoplasm	Cell_Structure	Protoplasm	The organized colloidal complex of organic and inorganic substances (as proteins and water) that constitutes the living nucleus, cytoplasm, plastids, and mitochondria of the cell. It is composed mainly of nucleic acids, proteins, lipids, carbohydrates, and inorganic salts.
C43597	c-myc_Gene_Mutation	Oncogene_Deregulation	c-myc Gene Mutation
C43598	Anal_Margin_Intraepithelial_Neoplasia	Anal_Intraepithelial_Neoplasia	Anal Margin Intraepithelial Neoplasia
C43599	Palifermin	Recombinant_Human_Keratinocyte_Growth_Factor	Palifermin|Kepivance	A recombinant form of the endogenous human keratinocyte growth factor.  Palifermin binds to epithelial cell surface receptors in the lining of the mouth and gastrointestinal tract, resulting in stimulation of epithelial cell proliferation, differentiation and upregulation of cytoprotective mechanisms. (NCI)
C43600	Datum	Retired_Concepts	Datum	A single item of factual information derived from measurement or research.
C43601	Gallbladder_Tubular_Adenoma	Gallbladder_Adenoma|Tubular_Adenoma	Gallbladder Tubular Adenoma
C43602	Gallbladder_Papillary_Adenoma	Gallbladder_Adenoma	Gallbladder Papillary Adenoma
C43603	Gallbladder_Tubulopapillary_Adenoma	Gallbladder_Adenoma	Gallbladder Tubulopapillary Adenoma
C43604	Gallbladder_Adenocarcinoma_Intestinal_Type	Gallbladder_Adenocarcinoma	Gallbladder Adenocarcinoma, Intestinal Type
C43605	Gallbladder_Clear_Cell_Adenocarcinoma	Clear_Cell_Adenocarcinoma|Gallbladder_Adenocarcinoma	Gallbladder Clear Cell Adenocarcinoma	A rare morphologic variant of gallbladder adenocarcinoma composed of malignant glandular epithelium with a predominance of glycogen rich clear cells.  The cells display hyperchromic nuclei and well-defined cytoplasmic borders.
C43606	Gallbladder_Intraepithelial_Neoplasia	Gallbladder_Neoplasm|Gastrointestinal_Intraepithelial_Neoplasia|Glandular_Cell_Intraepithelial_Neoplasia|Hepato-Biliary_Precancerous_Condition	Gallbladder Intraepithelial Neoplasia
C43607	Gallbladder_Flat_Intraepithelial_Neoplasia	Gallbladder_Intraepithelial_Neoplasia	Gallbladder Flat Intraepithelial Neoplasia
C43608	Qualification	Conceptual_Entities	Qualification	A quality, ability, or accomplishment that makes a person suitable for a particular position or task.
C43609	Gallbladder_Papillary_Intraepithelial_Neoplasia	Gallbladder_Intraepithelial_Neoplasia	Gallbladder Papillary Intraepithelial Neoplasia
C43610	Certification	Conceptual_Entities	Certification	A designation earned by a person that indicates that the person has specific knowledge, skills, or abilities in the view of the certifying body.  Similarly, a product or process can achieve certification indicating its suitability for a specific purpose.
C43611	License	Conceptual_Entities	License	Official or legal permission to do or own a specified thing.
C43612	Hepatobiliary_System	Gastrointestinal_System_Part	Hepatobiliary System
C43613	Visible_To	UML_Entity	Visible To	This property describes the intended viewing audience.
C43614	Hepatobiliary_Tissue	Tissue	Hepatobiliary Tissue
C43615	Bile_Duct_Tissue	Hepatobiliary_Tissue	Bile Duct Tissue
C43616	Bile_Duct_Epithelium	Bile_Duct_Tissue|Glandular_Epithelium	Bile Duct Epithelium
C43617	Intrahepatic_Bile_Duct_Epithelium	Bile_Duct_Epithelium	Intrahepatic Bile Duct Epithelium	Epithelium composed of one or more layers of glandular epithelial cells and a basement membrane lining the lumen of the intrahepatic bile duct.
C43618	Extrahepatic_Bile_Duct_Epithelium	Bile_Duct_Epithelium	Extrahepatic Bile Duct Epithelium
C43619	Cancer_Models_Database	Information_Resources	Cancer Models Database|caMOD	The cancer Models Database (caMOD) allows researchers to retrieve and submit animal models of cancer.  caMOD currently supports the Mouse Models of Human Cancer Consortium (MMHCC).
C43620	Enterprise_Java_Bean	Computer_Program	Enterprise Java Bean	The server-side component architecture for the Java 2 Platform, Enterprise Edition (J2EE) platform. EJB technology enables rapid and simplified development of distributed, transactional, secure and portable applications based on Java technology. (Sun Microsystems)
C43621	Cross-Reference	Document_Type	Cross-Reference	A notation or direction at one place (as in a book or filing system) to pertinent information at another place.
C43622	Experimental_Method	Research_Techniques	Experimental Method	The use of controlled observations and measurements to test hypotheses.
C43623	Persistent	General_Modifier	Persistent	Retained; never-ceasing.
C43624	In_the_Repository	Retired_Concepts	In the Repository	An indication that representative samples have been received and are present in the repository.
C43625	Pleomorphic_Hepatocellular_Carcinoma	Hepatocellular_Carcinoma	Pleomorphic Hepatocellular Carcinoma
C43626	Lamellar_Pattern	Morphologic_Architectural_Pattern	Lamellar Pattern
C43627	Sarcomatous_Hepatocellular_Carcinoma	Hepatocellular_Carcinoma	Sarcomatous Hepatocellular Carcinoma
C43628	KRAS-2_Gene_Mutation	Retired_Concepts	KRAS-2 Gene Mutation
C43629	Conjugated_Linoleic_Acid	Omega-6_Fatty_Acid	Conjugated Linoleic Acid|9,11-Conjugated Linoleic Acid|9,11-Linoleic Acid|9,11-Octadecadienoic Acid|CLA|Pamolyn 300	A slightly altered form of linoleic acid, which is an omega-6 fatty acid important to human health.  It is found in beef and dairy fats.
C43630	Hilar_Portion_of_the_Hepatic_Duct	Extrahepatic_Bile_Duct|Hepatic_Duct	Hilar Portion of the Hepatic Duct
C43633	Concept_Status	Status	Concept Status	The standing of a concept in relation to currently accepted classifications and concepts. In NCI Thesaurus and NCI Metathesaurus, concept status subtypes are linked to concepts with unusual and problematic characteristics that should be evaluated by people and/or programs before those concept are used. -- 2004.
C43634	Obsolete_Concept	Concept_Status	Obsolete Concept	Concept is no longer considered correct, and should not be used except as encountered in mappings and old data. -- 2004.
C43635	Deprecated_Concept	Concept_Status	Deprecated Concept	Concept is being phased out, but is still used with a reasonably clear meaning (example: Mesenchymoma). -- 2004.
C43636	Provisional_Concept	Concept_Status	Provisional Concept	Concept is a novel one that may or may not pass the test of time, and is particularly open to change, requiring caution in its use. -- 2004.
C43637	Header_Concept	Concept_Status	Header Concept	Concept indicates something about concepts grouped under it, but not intended for coding etc. (example: Neoplasm by Site). -- 2004.
C43638	UMLS_Cross-Reference_Concept	Concept_Status	UMLS Cross-Reference Concept	Concept is kept separate from one or more closely related NCI concepts, because it contains synonymy or other features not considered valid for NCI systems (NCI Metathesaurus only). This should apply only to UMLS concepts NCI cannot edit. NCI users should normally look to the related NCI concepts to use instead. -- 2004.
C43639	NCI_Thesaurus_Entity	Terminology_Entity	NCI Thesaurus Entity	The terminology entities that represent the elements that form and define the NCI Thesaurus.
C43640	NCI_Namespace	NCI_Thesaurus_Entity	NCI Namespace	The terminology entity that represents the NCI Thesaurus universe; the abstract container that holds all of the NCI Thesaurus terminology entities and concepts.
C43641	NCI_Thesaurus_Kind	NCI_Thesaurus_Entity	NCI Thesaurus Kind	The type of thing (disjoint set) represented in the NCI Thesaurus.
C43642	Terminology_Kind	Terminology_Entity	Kind|Terminology Kind	Kinds are types. By definition, kinds are all pairwise disjoint from one another. In other words the sets of individuals of a given kind have no overlap with any other kind. A namespace can contain multiple kinds, and often will. (Apelon)
C43643	NCI_Thesaurus_Role	NCI_Thesaurus_Entity	NCI Thesaurus Role|Role	A specific non-hierarchical, named relationship between concepts present in the NCI Thesaurus.
C43644	NCI_Thesaurus_Property	NCI_Thesaurus_Entity	NCI Thesaurus Property|Property	A specific terminology property present in the NCI Thesaurus.
C43645	Terminology_Property	Terminology_Entity	Property|Terminology Property	Properties are a convenience that allows the knowledge engineer to attach auxilary or non-semantic external information to concepts. They can be used for anything whatsoever, and have no bearing on classification and do not inherit. Often they are used for storing documentation strings and numeric codes. (from Apelon)
C43646	NCI_Thesaurus_Association	NCI_Thesaurus_Entity	NCI Thesaurus Association|Association	An association is a non-hierarchical, named relationship between a source and target concept that does not affect classification and is not inherited by child concepts during classification.  Associations are bidirectional and have a stated inverse.  Unlike roles, associations do not have a domain or range.
C43647	NCI_Thesaurus_Qualifier	NCI_Thesaurus_Entity	NCI Thesaurus Qualifier|Qualifier	For each property or association you assign to a concept you also can specify an established qualifier type and value. For properties, the qualifier provides additional detail regarding the nature of a concept property (e.g., a property effective date, or an indicator reflecting that the property is Current). For associations, the qualifier provides additional detail regarding the nature of the concept association (for example, the degree of accuracy of the relationship, such as Usually).
C43648	NCI_Thesaurus_Association_Qualifier	NCI_Thesaurus_Qualifier	NCI Thesaurus Association Qualifier|Association Qualifier	For each association you assign to a concept you also can specify an established qualifier type and value. The qualifier provides additional detail regarding the nature of the concept association (for example, the degree of accuracy of the relationship, such as Usually).
C43649	NCI_Thesaurus_Property_Qualifier	NCI_Thesaurus_Qualifier	NCI Thesaurus Property Qualifier|Property Qualifier	For each property you assign to a concept you also can specify an established qualifier type and value. The qualifier provides additional detail regarding the nature of a concept property (e.g., a property effective date, or an indicator reflecting that the property is Current).
C43650	Alaska_Indian	Alaska_Native	Alaska Indian
C43651	Abnormal_Cell_Kind	NCI_Thesaurus_Kind	Abnormal_Cell_Kind	An enumeration of abnormal cell types that occur in human cells and in cells of experimental models of human cancer.
C43652	Anatomy_Kind	NCI_Thesaurus_Kind	Anatomy_Kind	Naturally occurring human biological structures, fluids, and substances.  Includes embryological, gross and micro anatomic structures.  Excludes proteins and protein complexes smaller than that that can be visualized by light microscopy.
C43653	Biological_Process_Kind	NCI_Thesaurus_Kind	Biological_Process_Kind	A Biological Process is an activity that occurs between organisms or that occurs within an organism and involves the function, or modification of function by external factors, of biologic molecules, biologic complexes, subcellular components, cells, tissues, organs, or organ systems.
C43654	Chemicals_and_Drugs_Kind	NCI_Thesaurus_Kind	Chemicals_and_Drugs_Kind	Organic and inorganic substances, elements, and isotopes used in research, or for the prevention, diagnosis, and/or treatment of disease states. Includes biologically active substances, that are either synthetically manufactured, or endogenous substances extracted and processed to be reintroduced into an organism.
C43655	Chemotherapy_Regimen_Kind	NCI_Thesaurus_Kind	Chemotherapy_Regimen_Kind	Combinations of multiple drugs used in standard and clinical trial treatments. They do not currently specify order, dosage or dosing interval of the individual ingredients.
C43656	Clinical_or_Research_Activity_Kind	NCI_Thesaurus_Kind	Clinical_or_Research_Activity_Kind	Includes concepts used to describe clinical or research events and activities.
C43657	Diagnostic_and_Prognostic_Factors_Kind	NCI_Thesaurus_Kind	Diagnostic_and_Prognostic_Factors_Kind	Characteristics of an organism or of a pathologic process that contribute to clinical diagnosis, treatment selection or prediction of clinical outcome.
C43658	EO_Anatomy_Kind	NCI_Thesaurus_Kind	EO_Anatomy_Kind	Naturally occurring biological structures in non-human organisms. Includes embryological, gross and micro anatomic structures in all species used in research, and as models of human cancer. Excludes proteins and protein complexes smaller than can be visualized by light microscopy.
C43659	EO_Findings_and_Disorders_Kind	NCI_Thesaurus_Kind	EO_Findings_and_Disorders_Kind	Classification of conditions of non-human organisms that are relevant to cancer. Includes observations, test results, history and other concepts relevant to characterization of cancer-related conditions in species used as models of human cancer.
C43660	Equipment_Kind	NCI_Thesaurus_Kind	Equipment_Kind	Supplies or apparatus used for cancer-related research, diagnosis or therapy.
C43661	Findings_and_Disorders_Kind	NCI_Thesaurus_Kind	Findings_and_Disorders_Kind	The Findings and Disorders Kind specifies human conditions relevant to cancer.  This kind includes observations, test results, history and other concepts relevant to characterization of human cancer-related conditions.  Non-neoplastic conditions of interest are also included in this kind.
C43662	Gene_Kind	NCI_Thesaurus_Kind	Gene_Kind	Any endogenous functionally coherent unit of nucleotide sequence, capable of being transcribed into a chemically related nucleic acid species with biologically functional significance.
C43663	Gene_Product_Kind	NCI_Thesaurus_Kind	Gene_Product_Kind	Endogenous RNAs, proteins, protein complexes and riboprotein complexes. Excludes exogenous chemicals.
C43664	Molecular_Abnormality_Kind	NCI_Thesaurus_Kind	Molecular_Abnormality_Kind	An enumeration of the molecular abnormalities that occur in human cells and tissues and non-human models of human cancer. Includes abnormalities such as translocation, polymorphism, under expression, over expression.
C43665	NCI_Kind	NCI_Thesaurus_Kind	NCI_Kind	Conceptual entities required by NCI operations and systems. Includes administrative, financial, organizational and quasiscientific concepts.
C43666	Organism_Kind	NCI_Thesaurus_Kind	Organism_Kind	A living entity; includes viruses.
C43667	Pathway_Kind	NCI_Thesaurus_Kind	Pathway_Kind	A reaction or series of reactions. Includes both anabolic and catabolic reactions, and functional outputs such as transcription, activation, promotion and so forth.
C43668	Properties_or_Attributes_Kind	NCI_Thesaurus_Kind	Properties_or_Attributes_Kind	Modifiers and qualifiers.  Any concept in the form of an adjective, adverb, passive voice verb.
C43669	Retired_Kind	NCI_Thesaurus_Kind	Retired_Kind	This kind contains concepts that have been removed from active NCI Thesaurus kinds to ensure the integrity of the vocabulary. The concept codes and identifiers in Retired_Kind will not be reused. In those cases where the concepts in this kind were semantically valid, equivalent concepts remain in the other NCI Thesaurus kinds. The concepts in this Kind should not be used for coding purposes and should be ignored by application software systems. History table entries show when the concepts were inactivated, and the properties OLD_CHILD, OLD_PARENT, OLD_KIND, OLD_ROLE, OLD_SOURCE_ROLE and OLD_STATE indicate the contents of the concept when it was in active status.
C43670	Technique_Kind	NCI_Thesaurus_Kind	Technique_Kind	Scientific or clinical procedures and methods.
C43671	Bangladeshi	South_Asian	Bangladeshi	A person from Bangladesh or of that ancestry.
C43672	Sri_Lankan	South_Asian	Sri Lankan	A person from Sri Lanka or of that ancestry.
C43673	Bhutanese	Asian	Bhutanese	A person from Bhutan or of that ancestry.
C43674	Burmese	Asian	Burmese	A person from Myanmar (formerly Burma) or of that ancestry.
C43675	Taiwanese	Asian	Taiwanese	A person from Taiwan or of that ancestry.
C43676	Accepted_Therapeutic_Use_For_Property	NCI_Thesaurus_Property	Accepted_Therapeutic_Use_For	Indicates a disease or condition for which this drug is an accepted treatment.  Used in Chemicals and Drug Kind.
C43677	BioCarta_ID_Property	NCI_Thesaurus_Property	BioCarta_ID	Indicates the BioCarta ID code for a pathway. It can be used to link a BioCarta pathway reference to the primary pathway information.
C43678	CAS_Registry_Property	NCI_Thesaurus_Property	CAS_Registry	Indicates the Chemical Abstracts Service number for a Chemical or Drug.
C43679	Citation_Property	NCI_Thesaurus_Property	Citation	Provides a journal reference.
C43680	DEFINITION_Property	NCI_Thesaurus_Property	DEFINITION	English language definitions of what NCI, or selected sources, means by the concept. These are limited to 1024 characters. They also include information about the definition's source that can easily be interpreted by software.
C43681	DesignNote_Property	NCI_Thesaurus_Property	DesignNote	Design notes are notations made by NCI vocabulary curators. They are intended to provide supplemental, unstructured information to the user or additional insight about the concept.
C43682	Display_Name_Property	NCI_Thesaurus_Property	Display_Name|Display Name	Provides an alternative Preferred Name for use in some NCI systems.
C43683	Editor_Note_Property	NCI_Thesaurus_Property	Editor_Note	Provides a place for an editor to record information that another editor may need to know about how a concept was modeled. These are used for internal purposes and are not published.
C43684	FULL_SYN_Property	NCI_Thesaurus_Property	FULL_SYN|Synonym with Source Data	Fully qualified synonym, contains the string, term type, source, and an optional source code if appropriate. Each subfield is deliniated to facilitate interpretation by software.
C43685	GenBank_Accession_Number_Property	NCI_Thesaurus_Property	GenBank_Accession_Number	Indicates the accession number for a Gene within the GenBank database.
C43686	Gene_Encodes_Product_Property	NCI_Thesaurus_Property	Gene_Encodes_Product	Indicates the protein or RNA product expressed by a gene.
C43687	GO_Annotation_Property	NCI_Thesaurus_Property	GO_Annotation	Contains a value that can be used for cross-referencing to relevant entries in the Gene Ontology database.
C43688	Homologous_Gene_Property	NCI_Thesaurus_Property	Homologous_Gene	This indicates genes from other organisms that are similar in sequence and provide insight to the gene's function.
C43689	Image_Link_Property	NCI_Thesaurus_Property	Image_Link	Provides a link to an image in an external database.
C43690	In_Clinical_Trial_For_Property	NCI_Thesaurus_Property	In_Clinical_Trial_For	Indicates a disease for which this drug is currently being tested as a potential treatment.
C43691	IND_Code_Property	NCI_Thesaurus_Property	IND_Code	Investigational New Drug Code. Code assigned by the FDA to a new drug or device before entering a clinical trial; it is utilized in some NCI systems.
C43692	KEGG_ID_Property	NCI_Thesaurus_Property	KEGG_ID	Indicates the KEGG ID code for a pathway. It can be used to link a KEGG pathway reference to the primary pathway information.
C43693	Locus_ID_Property	NCI_Thesaurus_Property	Locus_ID|GeneID	Indicates the accession number for a Protein or Gene within the LocusLink database.
C43694	LONG_DEFINITION_Property	NCI_Thesaurus_Property	LONG_DEFINITION	Used to house the full text of a definition that is too long to conform to the 1024 character limit of a DEFINITION.
C43695	Maps_To_LASH_Property	NCI_Thesaurus_Property	Maps_To_LASH	Used for mapping from the IMT disease codes used by NCI's Cancer Therapy Evaluation Program (CTEP) to the LASH morphology and topography. This is not an exact mapping.
C43696	Mitelman_Code_Property	NCI_Thesaurus_Property	Mitelman_Code	Felix Mitelman's codes for the topography and morphology terms he uses to code his Chromosome Aberrations Database, data which is included in NCI's Cancer Genome Anatomy Project (CGAP) databases.
C43697	NCI_META_CUI_Property	NCI_Thesaurus_Property	NCI_META_CUI	Contains a Concept Unique Identifier for those concepts that appear in NCI Metathesaurus but not in the NLM UMLS.
C43698	NDFRT_Code_Property	NCI_Thesaurus_Property	NDFRT_Code	Holds the unique US Veterans Affairs Administration National Drug Formulary Reference Terminology concept code associated with the NDFRT_Name.
C43699	NDFRT_Name_Property	NCI_Thesaurus_Property	NDFRT_Name	Used to hold US Veterans Affairs Administration National Drug Formulary Reference Terminology concept name with the same intended meaning as the associated Thesaurus Concept. Used for the purpose of mapping between NDFRT and NCI Thesaurus.
C43700	NSC_Code_Property	NCI_Thesaurus_Property	NSC_Code	Drug codes provided by NCI's Developmental Therapeutics Program (DTP).
C43701	OLD_CHILD_Property	NCI_Thesaurus_Property	OLD_CHILD	Used to store the name of children concepts present at the time a concept was retired.
C43702	OLD_KIND_Property	NCI_Thesaurus_Property	OLD_KIND	Used to store the name of the concept's kind at the time a concept was retired.
C43703	OLD_PARENT_Property	NCI_Thesaurus_Property	OLD_PARENT	Used to store the name of parent concepts present at the time a concept was retired.
C43704	OLD_ROLE_Property	NCI_Thesaurus_Property	OLD_ROLE	Used to store the name and value of asserted roles present at the time a concept was retired.
C43705	OLD_STATE_Property	NCI_Thesaurus_Property	OLD_STATE	Used to store the state of a concept, primitive or defined, at the time a concept was retired.
C43706	OMIM_Number_Property	NCI_Thesaurus_Property	OMIM_Number	Indicates the accession number for a Protein or Gene within the OMIM database.
C43707	Preferred_Name_Property	NCI_Thesaurus_Property	Preferred_Name	The preferred name is the word or phrase that NCI uses by preference to refer to the concept.
C43708	PubMedID_Primary_Reference_Property	NCI_Thesaurus_Property	PubMedID_Primary_Reference	Used by the MMHCC vocabulary to provide a primary reference for descriptions of mouse diseases.
C43709	Related_Lash_Concept_Property	NCI_Thesaurus_Property	Related_Lash_Concept	Direct mapping from LASH (ELC2001) to the NCI Thesaurus. This property is provided for use by the Cancer Genome Anatomy Project (CGAP) and the Cancer Molecular Analysis Project (CMAP).
C43710	Related_MedDRA_Code_Property	NCI_Thesaurus_Property	Related_MedDRA_Code	Nearest matching MedDRA code for MedDRA/ CTEP disease names used in coding CTEP Clinical Trials.
C43711	Subsource_Property	NCI_Thesaurus_Property	Subsource	Currently used by MMHCC to identify the source of various mouse disease concepts.
C43712	Swiss_Prot_Property	NCI_Thesaurus_Property	Swiss_Prot	Indicates the accession number for a Protein within the Swiss-Prot database.
C43713	Synonym_Property	NCI_Thesaurus_Property	Synonym	Synonyms are ways of referring to a concept that are valid alternatives to the preferred name that NCI uses to refer to the concept.
C43714	UMLS_CUI_Property	NCI_Thesaurus_Property	UMLS_CUI	Concept Unique Identifiers, or CUIs, are concept numbers assigned by the National Library of Medicine (NLM). If a concept in any NCI-maintained knowledgebase exists in the NLM Unified Medical Language System (UMLS), NCI includes the NLM CUI among the information we provide about the concept.
C43715	Indonesian	Asian	Indonesian	A person from Indonesia or of that ancestry.
C43716	Malaysian	Asian	Malaysian	A person from Malasyia or of that ancestry.
C43717	Okinawan	Asian	Okinawan	A person from the japanese island of Okinawa or of that ancestry.
C43718	Iwo_Jiman	Asian	Iwo Jiman	A person from Iwo Jima or of that ancestry.
C43719	Maldivian	Asian	Maldivian	A person from the Maldives or of that ancestry.
C43720	Nepalese	Asian	Nepalese	A person from Nepal or of that ancestry.
C43721	Singaporean	Asian	Singaporean	A person from Singapore or of that ancestry.
C43722	Madagascar_Race	Asian	Malagasy|Madagascar	A person from Madagascar or of that ancestry.
C43723	Anatomic_Structure_Has_Location_Role	NCI_Thesaurus_Role	Anatomic_Structure_Has_Location	Intended to be used to indicate the physical location of an anatomic structure in the body. Both domain and range for this role are Anatomy_Kind.
C43724	Anatomic_Structure_is_Physical_Part_of_Role	NCI_Thesaurus_Role	Anatomic_Structure_is_Physical_Part_of	Used to indicate that an anatomic structure has physical association with a broader system or organ. Both domain and range for this role are Anatomy_Kind.
C43725	Biological_Process_Has_Associated_Location_Role	NCI_Thesaurus_Role	Biological_Process_Has_Associated_Location	The organ, organ system, cellular or subcellular location where the process occurs in the living system. The domain and range kind for this role are Biological_Process_Kind and Anatomy_Kind, respectively.
C43726	Biological_Process_Has_Initiator_Chemical_or_Drug_Role	NCI_Thesaurus_Role	Biological_Process_Has_Initiator_Chemical_or_Drug	This role asserts the relationship between biological processes and drugs or chemicals that initiate the process. The role implicates the direct physical interaction of a chemical or drug with a target molecule or biologic complex that results in the initiation of the process. The domain and range kind for this role are Biological_Process_Kind and Chemicals_and_Drugs_Kind, respectively.
C43727	Biological_Process_Has_Initiator_Process_Role	NCI_Thesaurus_Role	Biological_Process_Has_Initiator_Process	The role implies a direct physical and functional interaction of an element of a preceding biological process with a target molecule or complex of the stated process. Both, the domain and the range for this role, is the Biological_Process_Kind.
C43728	Biological_Process_Has_Result_Anatomy_Role	NCI_Thesaurus_Role	Biological_Process_Has_Result_Anatomy	This role asserts that some organ, tissue or cellular function results in the formation of a subcellular complex, structure, cell, or tissue. The role is used to establish this relationship between the biological process and the anatomical factor formed. The domain and range kind for this role are Biological_Process_Kind and Anatomy_Kind, respectively.
C43729	Biological_Process_Has_Result_Biological_Process_Role	NCI_Thesaurus_Role	Biological_Process_Has_Result_Biological_Process	This role asserts that the end result of a biological process initiates a subsequent biological process. Both the domain and the range for this role is the Biological_Process_Kind.
C43730	Biological_Process_Has_Result_Chemical_or_Drug_Role	NCI_Thesaurus_Role	Biological_Process_Has_Result_Chemical_or_Drug	This role asserts that the endpoint of a biological process is the creation of a molecule that is a value included in the Drugs or Chemical Kind. The domain and range kind for this role are Biological_Process_Kind and Chemicals_and_Drugs_Kind, respectively.
C43731	Biological_Process_Is_Part_of_Process_Role	NCI_Thesaurus_Role	Biological_Process_Is_Part_of_Process	This role asserts that a biological process operates as a component of another biological process. Both the domain and the range for this role is the Biological_Process_Kind.
C43732	Chemical_or_Drug_Affects_Abnormal_Cell_Role	NCI_Thesaurus_Role	Chemical_or_Drug_Affects_Abnormal_Cell	Used to establish the relation of a therapeutic agent and an abnormal cell target associated with a disease condition.  By pointing to abnormal cells, the therapeutic treatment of a drug can be more clearly conveyed.  The domain and range for this role are Chemicals_and_Drugs_Kind and Abnormal_Cell_Kind, respectively.
C43733	Chemical_or_Drug_Affects_Cell_Type_or_Tissue_Role	NCI_Thesaurus_Role	Chemical_or_Drug_Affects_Cell_Type_or_Tissue	Use in representing intended target cells of chemicals or drugs.  This does not include unintended target cells or tissues that were associated with side effect or toxicity of chemicals or drugs.  The domain and range for this role are Chemicals_and_Drugs_Kind and Anatomy_Kind, respectively.
C43734	Chemical_Or_Drug_Affects_Gene_Product_Role	NCI_Thesaurus_Role	Chemical_Or_Drug_Affects_Gene_Product	Used to represent the target of a therapeutic agent, one with which it has direct interaction.  It is not to be used to implicate any general specific association (e.g., involvement, interferenceinhibition or cleavage) with a referenced gene product.  The domain and range for this role are Chemicals_and_Drugs_Kind and Gene_Product_Kind, respectively.
C43735	Chemical_or_Drug_FDA_Approved_for_Disease_Role	NCI_Thesaurus_Role	Chemical_or_Drug_FDA_Approved_for_Disease	This role describes disease treatments by drugs that are approved by FDA.  The domain and range for this role are Chemicals_and_Drugs_Kind and Findings_and_Disorders_Kind, respectively.
C43736	Chemical_or_Drug_Has_Accepted_Therapeutic_Use_For_Role	NCI_Thesaurus_Role	Chemical_or_Drug_Has_Accepted_Therapeutic_Use_For
C43737	Chemical_or_Drug_Has_Mechanism_Of_Action_Role	NCI_Thesaurus_Role	Chemical_or_Drug_Has_Mechanism_Of_Action	This role implies the interaction or binding of an active ingredient of a drug/chemical agent at the molecular level with its target. When possible, the role value should reflect the direct alteration of function of a target molecule or complex.  The domain and range for this role are Chemicals_and_Drugs_Kind and Biological_Process_Kind, respectively.
C43738	Chemical_or_Drug_Has_Physiologic_Effect_Role	NCI_Thesaurus_Role	Chemical_or_Drug_Has_Physiologic_Effect	This role describes the primary detectable alterations of subcellular, cellular, tissue, or organ functions that directly result from alteration of function of a target biological molecule or complex caused by interaction of a therapeutic agent with a target molecule or complex.  The domain and range for this role are Chemicals_and_Drugs_Kind and Biological_Process_Kind, respectively.
C43739	Chemical_or_Drug_Has_Study_Therapeutic_Use_For_Role	NCI_Thesaurus_Role	Chemical_or_Drug_Has_Study_Therapeutic_Use_For
C43740	Chemical_or_Drug_Is_Metabolized_By_Enzyme_Role	NCI_Thesaurus_Role	Chemical_or_Drug_Is_Metabolized_By_Enzyme	This role addresses the pharmacokinetics concern of an agent.  Certain agents or pro-drugs need to be activated by an enzyme before the active form can deliver its action whereas others are specifically inactivated by an enzyme.  The domain and range for this role are Chemicals_and_Drugs_Kind and Gene_Product_Kind, respectively.
C43741	Chemical_or_Drug_Plays_Role_in_Biological_Process_Role	NCI_Thesaurus_Role	Chemical_or_Drug_Plays_Role_in_Biological_Process
C43742	Chemotherapy_Regimen_Has_Component_Role	NCI_Thesaurus_Role	Chemotherapy_Regimen_Has_Component	This role specifies the component agents which are used in a particular chemotherapy regimen.  The domain and the range for this role are Chemotherapy_Regimen_Kind and Chemicals_and_Drugs_Kind, respectively.
C43743	Conceptual_Part_Of_Role	NCI_Thesaurus_Role	Conceptual_Part_Of	This role is used to indicate a conceptual entity is a sub-entity of another conceptual entity.  Both the domain and the range for this role are NCI_Kind.
C43744	Disease_Excludes_Abnormal_Cell_Role	NCI_Thesaurus_Role	Disease_Excludes_Abnormal_Cell	This role can be seen as part of a role hierarchy and can be viewed as a specialization of Disease_Has_Abnormal_Cell; the role can be used to negate the positive assertions made by the role Disease_Has_Abnormal_Cell.  The roles share the same domain, range and value domain.
C43745	Disease_Excludes_Cytogenetic_Abnormality_Role	NCI_Thesaurus_Role	Disease_Excludes_Cytogenetic_Abnormality	This role can be seen as part of a role hierarchy and can be viewed as a specialization of Disease_Has_Cytogenetic_Abnormality; the role can be used to negate the positive assertions made by the role Disease_Has_Cytogenetic_Abnormality.  The roles share the same domain, range and value domain.
C43746	Disease_Excludes_Finding_Role	NCI_Thesaurus_Role	Disease_Excludes_Finding	This role can be seen as part of a role hierarchy and can be viewed as a specialization of Disease_Has_Finding; the role can be used to negate the positive assertions made by the role Disease_Has_Finding.  The roles share the same domain, range and value domain.
C43747	Disease_Excludes_Metastatic_Anatomic_Site_Role	NCI_Thesaurus_Role	Disease_Excludes_Metastatic_Anatomic_Site	This role can be seen as part of a role hierarchy and can be viewed as a specialization of Disease_Has_ Metastatic_Anatomic_Site; the role can be used to negate the positive assertions made by the role Disease_Has_ Metastatic_Anatomic_Site.  The roles share the same domain, range and value domain.
C43748	Disease_Excludes_Molecular_Abnormality_Role	NCI_Thesaurus_Role	Disease_Excludes_Molecular_Abnormality	This role can be seen as part of a role hierarchy and can be viewed as a specialization of Disease_Has_ Molecular_Abnormality; the role can be used to negate the positive assertions made by the role Disease_Has_ Molecular_Abnormality.  The roles share the same domain, range and value domain.
C43749	Disease_Excludes_Normal_Cell_Origin_Role	NCI_Thesaurus_Role	Disease_Excludes_Normal_Cell_Origin	This role can be seen as part of a role hierarchy and can be viewed as a specialization of Disease_Has_ Normal_Cell_Origin; the role can be used to negate the positive assertions made by the role Disease_Has_ Normal_Cell_Origin.  The roles share the same domain, range and value domain.
C43750	Disease_Excludes_Normal_Tissue_Origin_Role	NCI_Thesaurus_Role	Disease_Excludes_Normal_Tissue_Origin	This role can be seen as part of a role hierarchy and can be viewed as a specialization of Disease_Has_Normal_Tissue_Origin; the role can be used to negate the positive assertions made by the role Disease_Has_ Normal_Tissue_Origin.  The roles share the same domain, range and value domain.
C43751	Disease_Excludes_Primary_Anatomic_Site_Role	NCI_Thesaurus_Role	Disease_Excludes_Primary_Anatomic_Site	This role can be seen as part of a role hierarchy and can be viewed as a specialization of Disease_Has_Associated_Anatomic_Site; the role can be used to negate the positive assertions made by the role Disease_Has_ Primary_Anatomic_Site.  The roles share the same domain, range and value domain.
C43752	Disease_Has_Abnormal_Cell_Role	NCI_Thesaurus_Role	Disease_Has_Abnormal_Cell	Disease_Has_Abnormal_Cell is a defining role used to relate the concept of the disease to the type of neoplastic cell present in and characteristic of the disease.  The domain of the disease concept is the Findings_and_Disorders_Kind, the range of which is Abnormal_Cell_Kind.  The value domain within the range is the Neoplastic_Cell subset.
C43753	Disease_Has_Associated_Anatomic_Site_Role	NCI_Thesaurus_Role	Disease_Has_Associated_Anatomic_Site	Disease_Has_Associated_Anatomic_Site is a non-defining role used to relate the concept of the disease to the general site, structure or system where the more specific pathological process is located.  The domain of the disease concept is the Findings_and_Disorders_Kind, the range of which is the Anatomy_Kind.  The value domain consists of all concepts within the Anatomy_Kind.
C43754	Disease_Has_Associated_Disease_Role	NCI_Thesaurus_Role	Disease_Has_Associated_Disease	Disease_Has_Associated_Disease is a non-defining role used to relate the concept of the disease to another disease or disorder, but without specification or limitation of the relationship (causality or timing for example.)  The domain and range of the disease concept is the Findings_and_Disorders_Kind.  The value domain consists of the Diseases and Disorders subset within the Findings_and_Disorders_Kind.
C43755	Disease_Has_Cytogenetic_Abnormality_Role	NCI_Thesaurus_Role	Disease_Has_Cytogenetic_Abnormality	Disease_Has_Cytogenetic_Abnormality is a non-defining role used to relate the concept of the disease to the type of chromosomal abnormality present in the specified disease state.  The domain of the disease concept is the Findings_and_Disorders_Kind, the range of which is the Molecular_Abnormality_Kind.  The value domain within the range is the Cytogenic Abnormality subset.
C43756	Disease_Has_Finding_Role	NCI_Thesaurus_Role	Disease_Has_Finding	Disease_Has_Finding is a defining role used to relate the concept of the disease to a clinical observation, sign or symptom present in and characteristic of the disease.  The domain and range of the disease concept is the Findings_and_Disorders_Kind.  The value domain consists of all concepts within the Findings_and_Disorders_Kind.
C43757	Disease_Has_Metastatic_Anatomic_Site_Role	NCI_Thesaurus_Role	Disease_Has_Metastatic_Anatomic_Site	Disease_Has_Metastatic_Anatomic_Site is a non-defining role used to relate the concept of the disease to the site of a metastatic lesion associated with the disease.  The domain of the disease concept is the Findings_and_Disorders_Kind, the range of which is the Anatomy_Kind.  The value domain consists of all concepts within the Anatomy_Kind.
C43758	Disease_Has_Molecular_Abnormality_Role	NCI_Thesaurus_Role	Disease_Has_Molecular_Abnormality	Disease_Has_Molecular_Abnormality is a non-defining role used to relate the concept of the disease to the type of Molecular Abnormality present in the specified disease state.  The domain of the disease concept is the Findings_and_Disorders_Kind, the range of which is the Molecular_Abnormality_Kind.  The value domain consists of all concepts within the Molecular_Abnormality_Kind.
C43759	Disease_Has_Normal_Cell_Origin_Role	NCI_Thesaurus_Role	Disease_Has_Normal_Cell_Origin	Disease_Has_Normal_Cell_Origin is a defining role used to relate the concept of the disease to the type of normal cell in which the disease process began.  The domain of the disease concept is the Findings_and_Disorders_Kind, the range of which is the Anatomy_Kind.  The value domain within the range is the Normal Cell subset.
C43760	Disease_Has_Normal_Tissue_Origin_Role	NCI_Thesaurus_Role	Disease_Has_Normal_Tissue_Origin	Disease_Has_Normal_Tissue_Origin is a defining role used to relate the concept of the disease to the type of normal tissue in which the disease process began.  The domain of the disease concept is the Findings_and_Disorders_Kind, the range of which is the Anatomy_Kind.  The value domain within the range is the Tissue subset.
C43761	Disease_Has_Primary_Anatomic_Site_Role	NCI_Thesaurus_Role	Disease_Has_Primary_Anatomic_Site	Disease_Has_Primary_Anatomic_Site is a defining role used to relate the concept of the disease to the anatomical site where the originating pathological process is located.  The domain of the disease concept is the Findings_and_Disorders_Kind, the range of which is the Anatomy_Kind.  The value domain consists of all concepts within the Anatomy_Kind.
C43762	Disease_Is_Grade_Role	NCI_Thesaurus_Role	Disease_Is_Grade	The role is used to relate the disease concepts to a grading system, which refer to a system for classifying cancer cells in terms of how abnormal they appear when examined under a microscope. The domain of the disease concept is Findings_and_Disorders_Kind, the range of which is the Properties_or_Attributes_Kind. The value domain within the range is the Disease_Grade_Modifier subset.
C43763	Disease_is_Stage_Role	NCI_Thesaurus_Role	Disease_Is_Stage	This is a defining role used to relate the concept of the disease to the disease stage.  The stage refers to extent to which a cancer has spread from the original site to other parts of the body.  The domain of the disease concept is Findings_and_Disorders_Kind, the range of which is the Properties_or_Attributes_Kind.  The value domain within the range is the Disease_Stage_Modifier subset.
C43764	Disease_May_Have_Abnormal_Cell_Role	NCI_Thesaurus_Role	Disease_May_Have_Abnormal_Cell	The non-defining role Disease_May_Have_Abnormal_Cell represents non-essential characteristics which are true in some cases.  The domain, range and value domain of this role are identical to those of the role Disease_Has_Abnormal_Cell.
C43765	Disease_May_Have_Associated_Disease_Role	NCI_Thesaurus_Role	Disease_May_Have_Associated_Disease	The non-defining role Disease_May_Have_Associated_Disease represents non-essential characteristics which are true in some cases.  The domain, range and value domain of this role are identical to those of the role Disease_Has_Associated_Disease.
C43766	Disease_May_Have_Cytogenetic_Abnormality_Role	NCI_Thesaurus_Role	Disease_May_Have_Cytogenetic_Abnormality	The non-defining role Disease_May_Have_Cytogenetic_Abnormality represents non-essential characteristics which are true in some cases.  The domain, range and value domain of this role are identical to those of the role Disease_Has_Cytogenetic_Abnormality.
C43767	Disease_May_Have_Finding_Role	NCI_Thesaurus_Role	Disease_May_Have_Finding	The non-defining role Disease_May_Have_Finding represents non-essential characteristics which are true in some cases.  The domain, range and value domain of this role are identical to those of the role Disease_Has_Finding.
C43768	Disease_May_Have_Molecular_Abnormality_Role	NCI_Thesaurus_Role	Disease_May_Have_Molecular_Abnormality	The non-defining role Disease_May_Have_Molecular_Abnormality represents non-essential characteristics which are true in some cases.  The domain, range and value domain of this role are identical to those of the role Disease_Has_Molecular_Abnormality.
C43769	Disease_May_Have_Normal_Cell_Origin_Role	NCI_Thesaurus_Role	Disease_May_Have_Normal_Cell_Origin	The non-defining role Disease_May_Have_Normal_Cell_Origin represents non-essential characteristics which are true in some cases.  The domain, range and value domain of this role are identical to those of the role Disease_Has_Normal_Cell_Origin.
C43770	Disease_May_Have_Normal_Tissue_Origin_Role	NCI_Thesaurus_Role	Disease_May_Have_Normal_Tissue_Origin	The non-defining role Disease_May_Have_Normal_Tissue_Origin represents non-essential characteristics which are true in some cases.  The domain, range and value domain of this role are identical to those of the role Disease_Has_Normal_Tissue_Origin.
C43771	EO_Anatomic_Structure_is_Physical_Part_of_Role	NCI_Thesaurus_Role	EO_Anatomic_Structure_is_Physical_Part_of	The role is used to associate the anatomical structure of the experimental organism being a part of the larger structure or system. Both the domain and range for this role is EO_Anatomy_Kind.
C43772	EO_Derived_by_Technique_Role	NCI_Thesaurus_Role	EO_Derived_by_Technique
C43773	EO_Develops_Disease_Role	NCI_Thesaurus_Role	EO_Develops_Disease
C43774	EO_Disease_Has_Associated_Cell_Type_Role	NCI_Thesaurus_Role	EO_Disease_Has_Associated_Cell_Type	The role establishes a relationship between the disease or disorder in the experimental organism and the associated anatomy of the organism. The domain and range for this role are EO_Findings_and_Disorders_Kind and EO_Anatomy_Kind, respectively.
C43775	EO_Disease_Has_Associated_EO_Anatomy_Role	NCI_Thesaurus_Role	EO_Disease_Has_Associated_EO_Anatomy	The role is used to relate the concept of the disease in the experimental organism to the anatomical site of the experimental organism, where the more specific pathological process is located.  The domain is EO_Findings_and_Disorders_Kind and the range is the EO_Anatomy_Kind.
C43776	EO_Disease_Has_Property_or_Attribute_Role	NCI_Thesaurus_Role	EO_Disease_Has_Property_or_Attribute	The purpose of this role is to provide semantic relationship between a disease concept in an experimental organism and disease modifiers and qualifiers. The domain for this role is EO_Findings_and_Disorders_Kind and the range is Properties_or_Attributes_Kind.
C43777	EO_Disease_Maps_to_Human_Disease_Role	NCI_Thesaurus_Role	EO_Disease_Maps_to_Human_Disease	The role is used to establish a relationship between a disease in an experimental organism and a corresponding human disease. The domain and the range for this role is EO_Findings_and_Disorders_Kind and Findings_and_Disorders_Kind, respectively.
C43778	EO_Disease_Metastatic_to_EO_Anatomy_Role	NCI_Thesaurus_Role	EO_Disease_Metastatic_to_EO_Anatomy	The role is used to relate the concept of the disease in experimental organism to the site of a metastatic lesion associated with the disease.  The domain of the disease concept is the EO_Findings_and_Disorders_Kind, the range of which is the EO_Anatomy_Kind.
C43779	EO_Models_Human_Disease_Role	NCI_Thesaurus_Role	EO_Models_Human_Disease
C43780	Gene_Associated_With_Disease_Role	NCI_Thesaurus_Role	Gene_Associated_With_Disease	Molecular abnormalities in the gene may be associated with the manifestation of disease. The role is used to assert a link between gene and disease and is considered to have clinical relevance. The domain and range kind for this role are Gene_Kind and Findings_and_Disorders_Kind, respectively.
C43781	Gene_Found_In_Organism_Role	NCI_Thesaurus_Role	Gene_Found_In_Organism	This role is used to differentiate genes of same name and functions that originate from different organisms. The domain and range kind for this role are Gene_Kind and Organism_Kind, respectively.
C43782	Gene_Has_Abnormality_Role	NCI_Thesaurus_Role	Gene_Has_Abnormality	This role is used to establish a link between a gene and the genetic or molecular abnormalities that have been observed in human cells and tissues associated with cancers. The gene involved, could be over- or under-expressed, amplified, translocated, etc. to cause these abnormalities. The domain and range kind for this role are Gene_Kind and Molecular_Abnormality_Kind, respectively.
C43783	Gene_Has_Physical_Location_Role	NCI_Thesaurus_Role	Gene_Has_Physical_Location	The role is used to link the gene with its actual physical extent on a chromosome, denoted by the chromosome number and start and end base positions (with numbering beginning at the telomere of the short p arm). The domain and range kind for this role are Gene_Kind and Anatomy_Kind, respectively.
C43784	Gene_In_Chromosomal_Location_Role	NCI_Thesaurus_Role	Gene_In_Chromosomal_Location	The role is used to assert a relationship between the gene and its general location, specified by chromosomal band position (infrequently by chromosome number or chromosome arm). The domain and range kind for this role are Gene_Kind and Anatomy_Kind, respectively.
C43785	Gene_is_Biomarker_of_Role	NCI_Thesaurus_Role	Gene_is_Biomarker_of	Often, expression or alteration in a gene is correlated with a particular disease or disease state. This role asserts this relationship and can suggest that the gene or protein is predictive of the disease or disease state. The domain and range kind for this role are Gene_Kind and Findings_and_Disorder_Kind, respectively.
C43786	Gene_is_Biomarker_Type_Role	NCI_Thesaurus_Role	Gene_is_Biomarker_Type	The role is used to designate the type of biomarker the gene is and points to a small tree of biomarker types (e.g., Disease Marker, Metabolic Marker, or Prognostic Marker). The domain and range kind for this role are Gene_Kind and Diagnostic_or_Prognostic_Factors_Kind, respectively.
C43787	Gene_Is_Element_in_Pathway_Role	NCI_Thesaurus_Role	Gene_Is_Element_in_Pathway	Biochemical pathways denote a sequence of chemical reactions of known or inferred interactions in a biological process which the gene encoded products carry out. This role is used to assert the relationships between the encoding gene products and the pathways in which they participate to carry out the biological process. The domain and range kind for this role are Gene_Kind and Pathway_Kind, respectively.
C43788	Gene_Plays_Role_in_Process_Role	NCI_Thesaurus_Role	Gene_Plays_Role_in_Process	This role intends to answer the question, "what biological function does the encoded product carry out?"  It refers to the function of the wild type gene/gene product. The domain and range kind for this role are Gene_Kind and Biological_Process_Kind, respectively.
C43789	Gene_Product_Encoded_by_Gene_Role	NCI_Thesaurus_Role	Gene_Product_Encoded_by_Gene	This role asserts the connection between a gene product and the gene that encodes it.  Since a protein can only be encoded by a single gene this is considered a defining role. The domain and range kind for this role are Gene_Product_Kind and Gene_Kind, respectively.
C43790	Gene_Product_Expressed_In_Tissue_Role	NCI_Thesaurus_Role	Gene_Product_Expressed_In_Tissue	Expression is the cellular production of the protein encoded by a particular gene. The role is used to link the protein information where it is expressed. The domain and range kind for this role are Gene_Product_Kind and Anatomy_Kind, respectively.
C43791	Gene_Product_Has_Abnormality_Role	NCI_Thesaurus_Role	Gene_Product_Has_Abnormality	This role is used to establish a link between a gene product and the molecular abnormalities that are observed in human cells and tissues in association with diseases such as cancers, for example over or under-expression of gene product. The domain and range kind for this role are Gene_Product_Kind and Molecular_Abnormality_Kind, respectively.
C43792	Gene_Product_Has_Associated_Anatomy_Role	NCI_Thesaurus_Role	Gene_Product_Has_Associated_Anatomy	This role is used to tie proteins to physical structures or to denote the typical subcellular location of the gene product. The domain and range kind for this role are Gene_Product_Kind and Anatomy_Kind, respectively.
C43793	Gene_Product_Has_Biochemical_Function_Role	NCI_Thesaurus_Role	Gene_Product_Has_Biochemical_Function	The role denotes the biochemical activity of the gene product. Both the domain and range for this role are Gene_Product_Kind.
C43794	Gene_Product_Has_Chemical_Classification_Role	NCI_Thesaurus_Role	Gene_Product_Has_Chemical_Classification	The role is intended for indicating the protein structure. Both the domain and range for this role are Gene_Product_Kind.
C43795	Gene_Product_Has_Malfunction_Type_Role	NCI_Thesaurus_Role	Gene_Product_Has_Malfunction_Type	The role is used to link proteins with a specific type of abnormality present in a disease state (e.g., overexpression, gene fusion, gene amplification, protein truncation).  The domain and range kind for this role are Gene_Product_Kind and Biological_Process_Kind, respectively.
C43796	Gene_Product_Has_Organism_Source_Role	NCI_Thesaurus_Role	Gene_Product_Has_Organism_Source	As with Gene_Found_In_Organism, this role is used to differentiate homologous proteins from different organisms. The domain and range kind for this role are Gene_Product_Kind and Organism_Kind, respectively.
C43797	Gene_Product_Has_Structural_Domain_Or_Motif_Role	NCI_Thesaurus_Role	Gene_Product_Has_Structural_Domain_Or_Motif	Information about protein domains or motifs can give insight into protein function. This role is used to indicate the presence of a specified domain or motif in a protein. The domain and range kind for this role are Gene_Product_Kind and Anatomy_Kind, respectively.
C43798	Gene_Product_is_Biomarker_of_Role	NCI_Thesaurus_Role	Gene_Product_is_Biomarker_of	The role is used to indicate that a gene product may contribute to clinical diagnosis, treatment selection or prediction of clinical outcome. The domain and range kind for this role are Gene_Product_Kind and Findings_and_Disorders_Kind, respectively.
C43799	Gene_Product_is_Biomarker_Type_Role	NCI_Thesaurus_Role	Gene_Product_is_Biomarker_Type	The role is used to designate the type of biomarker the gene product is and points to a small tree of biomarker types (e.g., Disease Marker, Metabolic Marker, or Prognostic Marker). The domain and range kind for this role are Gene_Kind and Diagnostic_or_Prognostic_Factors_Kind, respectively.
C43800	Gene_Product_Is_Element_in_Pathway_Role	NCI_Thesaurus_Role	Gene_Product_Is_Element_in_Pathway	Biochemical pathways denote sequence of chemical reactions of a known or inferred interaction in a biological process which the gene encoded product carries out. This role is used to assert a relationship between a gene product and the biochemical pathways in which it participates in order to carry out the biological process. The domain and range kind for this role are Gene_Product_Kind and Pathway_Kind, respectively.
C43801	Gene_Product_is_Physical_Part_of_Role	NCI_Thesaurus_Role	Gene_Product_is_Physical_Part_of	This role is used to indicate that a gene product normally functions either as a catalytic unit, regulatory unit, or a structural component of a "functional complex". Individual gene products are classified by their function or by their anticipated biological function. Both the domain and range for this role are Gene_Product_Kind.
C43802	Gene_Product_Malfunction_Associated_With_Disease_Role	NCI_Thesaurus_Role	Gene_Product_Malfunction_Associated_With_Disease	The role is used to assert a link between a gene product and a disease when it is considered to have clinical relevance. The domain and range kind for this role are Gene_Product_Kind and Findings_and_Disorders_Kind, respectively.
C43803	Gene_Product_Plays_Role_In_Biological_Process_Role	NCI_Thesaurus_Role	Gene_Product_Plays_Role_In_Biological_Process	The role is used to assert that a gene product participates in a specific biological process. The domain and range kind for this role are Gene_Product_Kind and Biological_Process_Kind, respectively.
C43804	Technique_Has_Associated_Condition_Role	NCI_Thesaurus_Role	Technique_Has_Associated_Condition	The role indicates that a procedure or method is used in association with a finding or disease condition. The domain and range for this role are Technique_Kind and Findings_and_Disorders_Kind, respectively.
C43805	Technique_Has_Purpose_Role	NCI_Thesaurus_Role	Technique_Has_Purpose	A technique is a well-defined procedure used to accomplish a specific activity or task. The choice of the technique depends on the purpose of the study. The domain and range for this role are Technique _Kind and Clinical_or_Research_Activity_Kind, respectively.
C43806	Technique_Has_Sample_or_Specimen_Anatomy_Role	NCI_Thesaurus_Role	Technique_Has_Sample_or_Specimen_Anatomy	The role asserts that a procedure or a method uses a biological or clinical sample of anatomic origin. The domain and range for this role are Technique _Kind and Anatomy_Kind, respectively.
C43807	Technique_Has_Sample_or_Specimen_Chemical_or_Drug_Role	NCI_Thesaurus_Role	Technique_Has_Sample_or_Specimen_Chemical_or_Drug	This role asserts that a procedure or method uses a specific chemical or drug. The domain and range for this role are Technique _Kind and Chemicals_and_Drugs_Kind, respectively.
C43808	Technique_Has_Target_Anatomy_Role	NCI_Thesaurus_Role	Technique_Has_Target_Anatomy	This role asserts that a procedure or method detects or targets an anatomic structure.  The domain and range for this role are Technique _Kind and Anatomy_Kind, respectively.
C43809	Technique_Has_Target_Chemical_or_Drug_Role	NCI_Thesaurus_Role	Technique_Has_Target_Chemical_or_Drug	This role asserts that a procedure or method detects or targets a specific chemical or drug. The domain and range for this role are Technique _Kind and Chemical_and_Drugs_Kind, respectively.
C43810	Technique_Has_Target_Disease_Role	NCI_Thesaurus_Role	Technique_Has_Target_Disease	This role asserts that a procedure or method detects, diagnoses, or treats a specified disease state. The domain and range for this role are Technique _Kind and Findings_and_Disorders_Kind, respectively.
C43811	Technique_Has_Target_Organism_Role	NCI_Thesaurus_Role	Technique_Has_Target_Organism	This role asserts that a procedure or method detects, targets, or treats a specified organism. The domain and range for this role are Technique _Kind and Organism_Kind, respectively.
C43812	Technique_Has_Target_Protein_Role	NCI_Thesaurus_Role	Technique_Has_Target_Protein	This role asserts that a procedure or method identifies, isolates, or inactivates a specified protein. The domain and range for this role are Technique _Kind and Gene_Product_Kind, respectively.
C43813	Technique_Is_Used_In_Technique_Role	NCI_Thesaurus_Role	Technique_Is_Used_In_Technique	Many techniques utilize other techniques or procedures in its accomplishment. This role emphasizes on the sub techniques used in the fulfillment of the procedure or method. Both the range and domain are Technique Kind.
C43814	Technique_Uses_Equipment_Role	NCI_Thesaurus_Role	Technique_Uses_Equipment	Many techniques require use of specific artifacts or pieces of equipment. The domain and range for this role are Technique_Kind and Equipment_Kind, respectively.
C43815	US_Department_of_Veterans_Affairs_National_Drug_Formulary_Reference_Terminology	Information_Resources	US Department of Veterans Affairs National Drug Formulary Reference Terminology|NDFRT|US Veterans' Administration National Drug Formulary Reference Terminology	Published by the US Veterans' Administration. National Drug File Reference Terminology covers clinical drugs used at the VA.
C43816	NCI_Thesaurus	Information_Resources	NCI Thesaurus|Thesaurus	The NCI Thesaurus is a product of NCI's Enterprise Vocabulary Services. It arose from the need to have an institute wide common terminology to integrate the diverse data systems in use throughout NCI.  Centralized coding of research related activities helped to meet various responsibilities of the Institute; however, supplementary data coding assigned independently by various components of the NCI made it difficult to find and combine related information across programs. By incorporating the terms in use by the various programs and mapping those to unique concepts, it was intended that the NCI Thesaurus would facilitate interoperability and data sharing within NCI. The NCI Thesaurus is a rigorous, cancer-centric, formal reference vocabulary with true is_a taxonomic structure, polyhierarchy, inferred partonomy, and other features that make it suitable for supporting complex query operations against appropriately coded data repositories.
C43817	Unified_Medical_Language_System	Information_Resources	Unified Medical Language System|NLM UMLS|UMLS	The purpose of NLM's Unified Medical Language System (UMLS) is to facilitate the development of computer systems that behave as if they "understand" the meaning of the language of biomedicine and health. To that end, NLM produces and distributes the UMLS Knowledge Sources and associated software tools for use in building or enhancing electronic information systems that create, process, retrieve, integrate, and/or aggregate biomedical and health data and information, as well as in informatics research. The UMLS Knowledge Sources are multi-purpose and can be applied in systems that perform a range of functions involving one or more types of information, e.g., patient records, scientific literature, guidelines, public health data. The associated software tools assist developers in customizing or using the UMLS Knowledge Sources. There are three UMLS Knowledge Sources: the Metathesaurus, the Semantic Network, and the SPECIALIST lexicon.
C43818	GenBank	Information_Resources	GenBank	GenBank is the NIH genetic sequence database, an annotated collection of all publicly available DNA sequences. GenBank records are annotated using a standard set of biological terms and show these annotations in a Feature Table. A new release is made every two months. GenBank is part of the International Nucleotide Sequence Database Collaboration, which comprises the DNA DataBank of Japan (DDBJ), the European Molecular Biology Laboratory (EMBL), and GenBank at NCBI. These three organizations exchange data on a daily basis. The GenBank database is designed to provide and encourage access within the scientific community to the most up to date and comprehensive DNA sequence information. Therefore, NCBI places no restrictions on the use or distribution of the GenBank data. GenBank is available for searching at NCBI via several methods.
C43819	Swiss-Prot	Information_Resources	Swiss-Prot	Swiss-Prot is a protein knowledgebase established in 1986 and maintained collaboratively, since 1987, by the Department of Medical Biochemistry of the University of Geneva (now the Swiss Institute of Bioinformatics) and the EMBL Data Library.  It is a curated protein sequence database which strives to provide a high level of annotation (such as the description of the function of a protein, its domains structure, post-translational modifications, variants, etc.), a minimal level of redundancy and high level of integration with other databases.
C43820	MedDRA	Information_Resources	MedDRA|Medical Dictionary for Regulatory Activities	MedDRA is an international medical terminology designed to support the classification, retrieval, presentation, and communication of medical information throughout the medical product regulatory cycle. MedDRA was developed under the auspices of the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH). The MedDRA Maintenance and Support Services Organization (MSSO) holds a contract with the International Federation of Pharmaceutical Manufacturers Associations (IFPMA) to maintain and support the implementation of the terminology.
C43821	Terminology_Concept	Terminology_Entity	NCI Thesaurus Concept|Concept|Terminology Concept	A concept is the basic unit of information contained in the Thesaurus. They describe sets of individuals in a given domain. A concept has a name, belongs to a Namespace and exists in relation to other concepts. The vertical relationships consist of "isa" statements that form a logical hierarchy (taxonomy or subsumption graph). In general, concepts above a given concept are referred to as superconcepts or parents and those below as subconcepts or children. In addition, there are horizontal named realationships between concepts called Roles, binary relations between concepts that provide a machine-interpretable definition of a concept and the means for discrimination of sibling concepts. A concept may also include Properties, named slots that allow attachment of external information to concepts.
C43822	Term_Source	Terminology_Entity	Term Source|Source|Term Source Property	An indicator of the particular group or agency that supplied a specific term.  All concepts are expected to have a single preferred name term with NCI specified as the source. In addition, a concept may have other, synonymous NCI atoms and may also have additional preferred names or synonyms from other sources. The term source resides in the third subfield of the FULL_SYN property.
C43823	Barbadian	African_Caribbean	Barbadian	A person from Barbados or of that ancestry.
C43824	Dominican	African_Caribbean	Dominican	A person from Dominica or of that ancestry.
C43825	Haitian	African_Caribbean	Haitian	A person from Haiti or of that ancestry.
C43826	Jamaican	African_Caribbean	Jamaican	A person from Jamaica or of that ancestry.
C43827	Tobagoan	African_Caribbean	Tobagoan	A person from Tobago or of that ancestry.
C43828	Trinidadian	African_Caribbean	Trinidadian	A person from Trinidad or of that ancestry.
C43829	West_Indian	African_Caribbean	West Indian	A person fromany of the West Indies islands or of that ancestry.
C43830	Botswanan	African	Botswanan|Motswana	A person from Botswana or of that ancestry.
C43831	Ethiopian	African	Ethiopian	A person from Ethiopia or of that ancestry.
C43832	Liberian	African	Liberian	A person from Liberia or of that ancestry.
C43833	Namibian	African	Namibian	A person from Namibia or of that ancestry.
C43834	Nigerian	African	Nigerian	A person from Nigeria or of that ancestry.
C43835	Zairean	African	Zairean	A person from Democratic Republic of the Congo (formerly Zaire) or of that ancestry.
C43836	Tokelauan	Polynesian	Tokelauan	A person from Tokelau or of that ancestry.
C43837	Guamanian_or_Chamorro	Micronesian	Guamanian or Chamorro	A person from Guam or the indigenous Chamorro people of Guam and the Mariana Islands or of that ancestry.
C43838	Mariana_Islander	Micronesian	Mariana Islander	A person from any of the Northern Mariana Islands or of that ancestry.
C43839	Marshallese	Micronesian	Marshallese	A person from any of the Marshall Islands or of that ancestry.
C43840	Palauan	Micronesian	Palauan	A person from Palau or of that ancestry.
C43841	Carolinian	Micronesian	Carolinian
C43842	Kosraean	Micronesian	Kosraean	A person from the Micronesian island of Kosrae or of that ancestry.
C43843	Pohnpeian	Micronesian	Pohnpeian	A person from the Micronesian island of Pohnpei or of that ancestry.
C43844	Saipanese	Micronesian	Saipanese	A person from any of the Saipan islands or of that ancestry.
C43845	Kiribati_Race	Micronesian	Kiribati	A person from Kiribati or of that ancestry.
C43846	Chuukese	Micronesian	Chuukese	A person from the Micronesian island of Chuuk or of that ancestry.
C43847	Yapese	Micronesian	Yapese	A person from the Micronesian island of Yap or of that ancestry.
C43848	Clear_Cell_Intrahepatic_Cholangiocarcinoma	Clear_Cell_Adenocarcinoma|Intrahepatic_Cholangiocarcinoma	Clear Cell Intrahepatic Cholangiocarcinoma	A morphologic variant of intrahepatic cholangiocarcinoma composed of malignant glandular epithelium, an abundant fibrous stroma, and the presence of clear cells. Clinical symptoms include abdominal pain, weight loss and malaise.
C43849	Solomon_Islander	Melanesian	Solomon Islander	A person from any of the Solomon Islands or of that ancestry.
C43850	New_Hebrides	Melanesian	New Hebrides	A person from any of the islands of Vanuatu or of that ancestry.
C43851	European	White	European	A person from any of the countries of Europe or of that ancestry.
C43852	Armenian	White	Armenian	A person from Armenia or of that ancestry.
C43853	English	White	English	A person from England or of that ancestry.
C43854	French	White	French	A person from France or of that ancestry.
C43855	German	White	German	A person from Germany or of that ancestry.
C43856	Irish	White	Irish	A person from Ireland or of that ancestry.
C43857	Italian	White	Italian	A person from Italy or of that ancestry.
C43858	Polish	White	Polish	A person from Poland or of that ancestry.
C43859	Scottish	White	Scottish	A person from Scotland or of that ancestry.
C43860	Russian	White	Russian	A person from Poland or of that ancestry.
C43861	Swedish	White	Swedish	A person from Sweden or of that ancestry.
C43862	Norwegian	White	Norwegian	A person from Norway or of that ancestry.
C43863	Ukranian	White	Ukranian	A person from Ukraine or of that ancestry.
C43864	Mongolian	Asian	Mongolian	A person from Mongolia or of that ancestry.
C43865	Finnish	White	Finnish	A person from Finland or of that ancestry.
C43866	Middle_Eastern_or_North_African	White	Middle Eastern or North African
C43867	Assyrian	Middle_Eastern_or_North_African	Assyrian	Assyrian is a collective term used to identify indigenous peoples of northern Iraq and neighboring areas of Syria and Turkey, who also identify themselves as Aramaeans and Chaldeans. They are the survivors of the formerly extensive Aramaic- or Syriac- speaking Christian community of northern Iraq, southeastern Turkey, and northwestern Iran. (from Wikipedia).
C43868	Egyptian	Middle_Eastern_or_North_African	Egyptian	A person from Egypt or of that ancestry.
C43869	Iranian	Middle_Eastern_or_North_African	Iranian	A person from Iran or of that ancestry.
C43870	Iraqi	Middle_Eastern_or_North_African	Iraqi	A person from Iraq or of that ancestry.
C43871	Lebanese	Middle_Eastern_or_North_African	Lebanese	A person from Lebanon or of that ancestry.
C43872	Palestinian	Middle_Eastern_or_North_African	Palestinian	The Palestinians are a group of mainly Arabic speakers who regard themselves as a distinct branch of the Arabic-speaking peoples, with family origin in Palestine being the defining characteristic. (Wikipedia)
C43873	Syrian	Middle_Eastern_or_North_African	Syrian	A person from Syria or of that ancestry.
C43874	Afghanistani	Middle_Eastern_or_North_African	Afghanistani	A person from Afghanistan or of that ancestry.
C43875	Israeli	Middle_Eastern_or_North_African	Israeli	A person from Israel or of that ancestry.
C43876	Arab	Middle_Eastern_or_North_African	Arab	A person with ethnic origins in the Semitic people originally from the Arabian peninsula and surrounding territories in the Middle East and northern Africa.
C43877	American_Indian	American_Indian_or_Alaska_Native	American Indian
C43878	Abenaki	American_Indian	Abenaki
C43879	Algonquian	American_Indian	Algonquian
C43880	Apache	American_Indian	Apache
C43881	Chiricahua	Apache	Chiricahua
C43882	Fort_Sill_Apache	Apache	Fort Sill Apache
C43883	Jicarilla_Apache	Apache	Jicarilla Apache
C43884	Lipan_Apache	Apache	Lipan Apache
C43885	Mescalero_Apache	Apache	Mescalero Apache
C43886	Oklahoma_Apache	Apache	Oklahoma Apache
C43887	Payson_Apache	Apache	Payson Apache
C43888	San_Carlos_Apache	Apache	San Carlos Apache
C43889	White_Mountain_Apache	Apache	White Mountain Apache
C43890	Arapaho	American_Indian	Arapaho
C43891	Northern_Arapaho	Arapaho	Northern Arapaho
C43892	Southern_Arapaho	Arapaho	Southern Arapaho
C43893	Wind_River_Arapaho	Arapaho	Wind River Arapaho
C43894	Arikara	American_Indian	Arikara
C43895	Assiniboine	American_Indian	Assiniboine
C43896	Assiniboine_Sioux	American_Indian	Assiniboine Sioux
C43897	Fort_Peck_Assiniboine_Sioux	Assiniboine_Sioux	Fort Peck Assiniboine Sioux
C43898	Bannock	American_Indian	Bannock
C43899	Blackfeet	American_Indian	Blackfeet
C43900	Brotherton	American_Indian	Brotherton
C43901	Burt_Lake_Band	American_Indian	Burt Lake Band
C43902	Caddo	American_Indian	Caddo
C43903	Oklahoma_Cado	Caddo	Oklahoma Cado
C43904	Cahuilla	American_Indian	Cahuilla
C43905	Agua_Caliente_Cahuilla	Cahuilla	Agua Caliente Cahuilla
C43907	Neutral_Epithelial_Mucin_Present	Morphologic_Finding	Neutral Epithelial Mucin Present
C43908	Bile_Pigment_Present	Morphologic_Finding	Bile Pigment Present
C43909	Augustine	Cahuilla	Augustine
C43910	Cabazon	Cahuilla	Cabazon
C43911	Los_Coyotes	Cahuilla	Los Coyotes
C43912	Morongo	Cahuilla	Morongo
C43913	Santa_Rosa_Cahuilla	Cahuilla	Santa Rosa Cahuilla
C43914	Torres_Martinez	Cahuilla	Torres-Martinez
C43915	California_Tribes	American_Indian	California Tribes
C43916	Canadian_and_Latin_American_Indian	American_Indian	Canadian and Latin American Indian
C43917	Catawba	American_Indian	Catawba
C43918	Cayuse	American_Indian	Cayuse
C43919	Chehalis	American_Indian	Chehalis
C43920	Chemakuan	American_Indian	Chemakuan
C43921	Hoh	Chemakuan	Hoh
C43922	Quileute	Chemakuan	Quileute
C43923	Chemehuevi	American_Indian	Chemehuevi
C43924	Cherokee	Cherokee_Shawnee	Cherokee
C43925	Cherokee_Shawnee	American_Indian	Cherokee Shawnee
C43926	Cheyenne	American_Indian	Cheyenne
C43927	Northern_Cheyenne	Cheyenne	Northern Cheyenne
C43928	Southern_Cheyenne	Cheyenne	Southern Cheyenne
C43929	Cheyenne_Arapaho	American_Indian	Cheyenne-Arapaho
C43930	Chickahominy	American_Indian	Chickahominy
C43931	Eastern_Chickahominy	Chickahominy	Eastern Chickahominy
C43932	Western_Chickahominy	Chickahominy	Western Chickahominy
C43933	Chickasaw	American_Indian	Chickasaw
C43934	Chinook	American_Indian	Chinook
C43935	Chippewa	American_Indian	Chippewa
C43936	Chippewa_Cree	American_Indian	Chippewa Cree
C43937	Rocky_Boy_s_Chippewa_Cree	Chippewa_Cree	Rocky Boy's Chippewa Cree
C43938	Chitimacha	American_Indian	Chitimacha
C43939	Choctaw	American_Indian	Choctaw
C43940	Clifton_Choctaw	Choctaw	Clifton Choctaw
C43941	Jena_Choctaw	Choctaw	Jena Choctaw
C43942	Mississippi_Choctaw	Choctaw	Mississippi Choctaw
C43943	Mowa_Band_of_Choctaw	Choctaw	Mowa Band of Choctaw
C43944	Oklahoma_Choctaw	Choctaw	Oklahoma Choctaw
C43945	Chumash	American_Indian	Chumash
C43946	Santa_Ynez	Chumash	Santa Ynez
C43947	Clear_Lake	American_Indian	Clear Lake
C43948	Coeur_D_Alene	American_Indian	Coeur D'Alene
C43949	Coharie	American_Indian	Coharie
C43950	Colorado_River	American_Indian	Colorado River
C43951	Colville	American_Indian	Colville
C43952	Comanche	American_Indian	Comanche
C43953	Oklahoma_Comanche	Comanche	Oklahoma Comanche
C43954	Coos_Lower_Umpqua_Siuslaw	American_Indian	Coos Lower Umpqua Siuslaw
C43955	Coos	American_Indian	Coos
C43956	Coquilles	American_Indian	Coquilles
C43957	Costanoan	American_Indian	Costanoan
C43958	Coushatta	American_Indian	Coushatta
C43959	Alabama_Coushatta	Coushatta	Alabama Coushatta
C43960	Health_Care_Organization	Other_Agency_or_Organization	Health Care Organization|HCO|Healthcare Organization	An organization that provides healthcare services or that is involved in the provision of health care activities. Groupings or subdivisions of an organization, such as departments, may also be considered as organizations where there is a need to identify them.
C43961	Cowlitz	Yakama_Cowlitz	Cowlitz
C43962	Cree	American_Indian	Cree
C43963	Creek	American_Indian	Creek
C43964	Croatan	American_Indian	Croatan
C43965	Crow	American_Indian	Crow
C43966	International_Commission_on_Radiation_Units_and_Measurements	Other_Agency_or_Organization	International Commission on Radiation Units and Measurements|ICRU|International Commission of Radiation Units and Measurements	The International Commission on Radiation Units and Measurements (ICRU) was established in 1925 by the International Congress of Radiology. Since its inception, it has had as its principal objective the development of internationally acceptable recommendations regarding (1) quantities and units of radiation and radioactivity; (2) procedures suitable for the measurement and application of these quantities in diagnostic radiology, radiation therapy, radiation biology, and industrial operations; and (3) physical data needed in the application of these procedures, the use of which tends to assure uniformity in reporting. The ICRU endeavors to collect and evaluate the latest data and information pertinent to the problems of radiation measurement and dosimetry, and to recommend in its publications the most acceptable values and techniques for current use. (http://www.ircu.org)
C43967	Cupeno	American_Indian	Cupeno
C43968	Agua_Caliente	Cupeno	Agua Caliente
C43969	Delaware_Indian	American_Indian	Delaware
C43970	Diegueno	American_Indian	Diegueno
C43971	Eastern_Tribes	American_Indian	Eastern Tribes
C43972	Esselen	American_Indian	Esselen
C43973	Fort_Belknap	American_Indian	Fort Belknap
C43974	Fort_Berthold	American_Indian	Fort Berthold
C43975	Fort_McDowell	American_Indian	Fort McDowell|Fort Mcdowell
C43976	Fort_Hall	American_Indian	Fort Hall
C43977	Gabrieleno	American_Indian	Gabrieleno
C43978	Grand_Ronde	American_Indian	Grand Ronde
C43979	Gros_Ventres	American_Indian	Gros Ventres
C43980	Atsina	Gros_Ventres	Atsina
C43981	Haliwa	American_Indian	Haliwa
C43982	Hidatsa	American_Indian	Hidatsa
C43983	Hoopa	American_Indian	Hoopa
C43984	Trinity	Hoopa	Trinity
C43985	Whilkut	Hoopa	Whilkut
C43986	Hoopa_Extension	American_Indian	Hoopa Extension
C43987	Houma	American_Indian	Houma
C43988	Inaja_Cosmit	American_Indian	Inaja-Cosmit
C43989	Iowa_Indian	American_Indian	Iowa
C43990	Iowa_of_Kansas_Nebraska	Iowa_Indian	Iowa of Kansas-Nebraska
C43991	Iowa_of_Oklahoma	Iowa_Indian	Iowa of Oklahoma
C43992	Iroquois	American_Indian	Iroquois
C43993	Juaneno	American_Indian	Juaneno
C43994	Kalispel	American_Indian	Kalispel
C43995	Karuk	American_Indian	Karuk
C43996	Kaw	American_Indian	Kaw
C43997	Kickapoo	American_Indian	Kickapoo
C43998	Oklahoma_Kickapoo	Kickapoo	Oklahoma Kickapoo
C43999	Texas_Kickapoo	Kickapoo	Texas Kickapoo
C44000	Kiowa	American_Indian	Kiowa
C44001	Oklahoma_Kiowa	Kiowa	Oklahoma Kiowa
C44002	Klallam	American_Indian	Klallam
C44003	Jamestown	Klallam	Jamestown
C44004	Lower_Elwha	Klallam	Lower Elwha
C44005	Port_Gamble_Klallam	Klallam	Port Gamble Klallam
C44006	Klamath	American_Indian	Klamath
C44007	Konkow	American_Indian	Konkow
C44008	Kootenai	Salish_and_Kootenai	Kootenai
C44009	Lassik	American_Indian	Lassik
C44010	Long_Island	American_Indian	Long Island
C44011	Matinecock	Long_Island	Matinecock
C44012	Montauk	Long_Island	Montauk
C44013	Poospatuck	Long_Island	Poospatuck
C44014	Setauket	Long_Island	Setauket
C44015	Luiseno	American_Indian	Luiseno
C44016	La_Jolla	Luiseno	La Jolla
C44017	Pala	Luiseno	Pala
C44018	Pauma	Luiseno	Pauma
C44019	Pechanga	Luiseno	Pechanga
C44020	Soboba	Luiseno	Soboba
C44021	Twenty_Nine_Palms	Luiseno	Twenty-Nine Palms
C44022	Temecula	Luiseno	Temecula
C44023	Lumbee	American_Indian	Lumbee
C44024	Lummi	American_Indian	Lummi
C44025	Maidu	American_Indian	Maidu
C44026	Mountain_Maidu	Maidu	Mountain Maidu
C44027	Nishinam	Maidu	Nishinam
C44028	Makah	American_Indian	Makah
C44029	Maliseet	American_Indian	Maliseet
C44030	Mandan	American_Indian	Mandan
C44031	Mattaponi	American_Indian	Mattaponi
C44032	Menominee	American_Indian	Menominee
C44033	Miami	American_Indian	Miami
C44034	Illinois_Miami	Miami	Illinois Miami
C44035	Indiana_Miami	Miami	Indiana Miami
C44036	Oklahoma_Miami	Miami	Oklahoma Miami
C44037	Miccosukee	American_Indian	Miccosukee
C44038	Micmac	American_Indian	Micmac
C44039	Aroostook	Micmac	Aroostook
C44040	Mission_Indians	American_Indian	Mission Indians
C44041	Miwok	American_Indian	Miwok
C44042	Modoc	American_Indian	Modoc
C44043	Mohegan	American_Indian	Mohegan
C44044	Mono	American_Indian	Mono
C44045	Nanticoke	American_Indian	Nanticoke
C44046	Narragansett	American_Indian	Narragansett
C44048	Dine	American_Indian	Dine|Navaho|Navajo
C44049	Alamo_Dine	Dine	Alamo Dine|Alamo Navaho|Alamo Navajo
C44050	Canoncito_Dine	Dine	Canoncito Dine|Canoncito Navaho|Canoncito Navajo
C44051	Ramah_Dine	Dine	Ramah Dine|Ramah Navaho|Ramah Navajo
C44052	Nez_Perce	American_Indian	Nez Perce
C44053	Nomalaki	American_Indian	Nomalaki
C44054	Northwest_Tribes	American_Indian	Northwest Tribes
C44055	Alsea	Northwest_Tribes	Alsea
C44056	Celilo	Northwest_Tribes	Celilo
C44057	Columbia_Indian	Northwest_Tribes	Columbia
C44058	Kalapuya	Northwest_Tribes	Kalapuya
C44059	Molala	Northwest_Tribes	Molala
C44060	Talakamish	Northwest_Tribes	Talakamish
C44061	Tenino	Northwest_Tribes	Tenino
C44062	Tillamook	Northwest_Tribes	Tillamook
C44063	Wenatchee	Northwest_Tribes	Wenatchee
C44064	Yahooskin	Northwest_Tribes	Yahooskin
C44065	Omaha	American_Indian	Omaha
C44066	Oregon_Athabaskan	American_Indian	Oregon Athabaskan
C44067	Osage	American_Indian	Osage
C44068	Otoe_Missouria	American_Indian	Otoe-Missouria
C44069	Ottawa	American_Indian	Ottawa
C44070	Burt_Lake_Ottawa	Ottawa	Burt Lake Ottawa
C44071	Michigan_Ottawa	Ottawa	Michigan Ottawa
C44072	Oklahoma_Ottawa	Ottawa	Oklahoma Ottawa
C44073	Paiute	Shoshone_Paiute	Paiute
C44074	Pamunkey	American_Indian	Pamunkey
C44075	Passamaquoddy	American_Indian	Passamaquoddy
C44076	Indian_Township	Passamaquoddy	Indian Township
C44077	Pleasant_Point_Passamaquoddy	Passamaquoddy	Pleasant Point Passamaquoddy
C44078	Pawnee	American_Indian	Pawnee
C44079	Oklahoma_Pawnee	Pawnee	Oklahoma Pawnee
C44080	Penobscot	American_Indian	Penobscot
C44081	Peoria	American_Indian	Peoria
C44082	Oklahoma_Peoria	Peoria	Oklahoma Peoria
C44083	Pequot	American_Indian	Pequot
C44084	Marshantucket_Pequot	Pequot	Marshantucket Pequot
C44085	Pima	American_Indian	Pima
C44086	Gila_River_Pima_Maricopa	Pima	Gila River Pima-Maricopa
C44087	Salt_River_Pima_Maricopa	Pima	Salt River Pima-Maricopa
C44088	Piscataway	American_Indian	Piscataway
C44089	Pit_River	American_Indian	Pit River
C44090	Pomo	American_Indian	Pomo
C44091	Ponca	American_Indian	Ponca
C44092	Nebraska_Ponca	Ponca	Nebraska Ponca
C44093	Oklahoma_Ponca	Ponca	Oklahoma Ponca
C44094	Potawatomi	American_Indian	Potawatomi
C44095	Powhatan	American_Indian	Powhatan
C44096	Pueblo	American_Indian	Pueblo
C44097	Concept_Status_Property	NCI_Thesaurus_Property	Concept_Status	The standing of a concept in relation to currently accepted classifications and concepts. In NCI Thesaurus concept status subtype indicates concepts with unusual and problematic characteristics that should be evaluated by people and/or programs before those concept are used.
C44098	Role_Has_Domain_Association	NCI_Thesaurus_Association	Role_Has_Domain	For an NCI Thesaurus role this association specifies the role's domain kind.
C44099	Role_Has_Range_Association	NCI_Thesaurus_Association	Role_Has_Range	For an NCI Thesaurus role this association specifies the role's range kind.
C44100	Role_Has_Parent_Association	NCI_Thesaurus_Association	Role_Has_Parent	For an NCI Thesaurus role this association specifies that the role exists as part of a role hierarchy and specifies the role's parent, the role that this role specializes.
C44101	Qualifier_Applies_To	NCI_Thesaurus_Association	Qualifier_Applies_To	Indicates the property or association that the qualifier is to be used with.
C44102	Puget_Sound_Salish	American_Indian	Puget Sound Salish
C44103	Quapaw	American_Indian	Quapaw
C44104	Quinault	American_Indian	Quinault
C44105	Rappahannock	American_Indian	Rappahannock
C44106	Reno_Sparks	American_Indian	Reno-Sparks
C44107	Round_Valley	American_Indian	Round Valley
C44108	Sac_and_Fox	American_Indian	Sac and Fox
C44109	Iowa_Sac_and_Fox	Sac_and_Fox	Iowa Sac and Fox
C44110	Missouri_Sac_and_Fox	Sac_and_Fox	Missouri Sac and Fox
C44111	Oklahoma_Sac_and_Fox	Sac_and_Fox	Oklahoma Sac and Fox
C44112	Salinan	American_Indian	Salinan
C44113	Salish	Salish_and_Kootenai	Salish
C44114	Salish_and_Kootenai	American_Indian	Salish and Kootenai
C44115	Schaghticoke	American_Indian	Schaghticoke
C44116	Scott_Valley	American_Indian	Scott Valley
C44117	Seminole	American_Indian	Seminole
C44118	Big_Cypress	Seminole	Big Cypress
C44119	Brighton	Seminole	Brighton
C44120	Florida_Seminole	Seminole	Florida Seminole
C44121	Hollywood_Seminole	Seminole	Hollywood Seminole
C44122	Oklahoma_Seminole	Seminole	Oklahoma Seminole
C44123	Serrano	American_Indian	Serrano
C44124	San_Manual	Serrano	San Manual
C44125	Shasta	American_Indian	Shasta
C44126	Shawnee	Cherokee_Shawnee	Shawnee
C44127	Absentee_Shawnee	Shawnee	Absentee Shawnee
C44128	Eastern_Shawnee	Shawnee	Eastern Shawnee
C44129	Shinnecock	American_Indian	Shinnecock
C44130	Shoalwater_Bay	American_Indian	Shoalwater Bay
C44131	Shoshone	Shoshone_Paiute	Shoshone
C44132	Shoshone_Paiute	American_Indian	Shoshone Paiute
C44133	Duck_Valley	Shoshone_Paiute	Duck Valley
C44134	Fallon	Shoshone_Paiute	Fallon
C44135	Fort_McDermitt	Shoshone_Paiute	Fort McDermitt
C44136	Siletz	American_Indian	Siletz
C44137	Sioux	American_Indian	Sioux
C44138	Blackfoot_Sioux	Lakota	Blackfoot Sioux
C44139	Brule_Sioux	Lakota	Brule Sioux
C44140	Cheyenne_River_Sioux	Lakota	Cheyenne River Sioux
C44141	Lakota	Sioux	Lakota|Lakota Sioux|Teton Sioux
C44142	Dakota	Sioux	Dakota|Dakota Sioux
C44143	Nakota	Sioux	Nakota|Nakota Sioux
C44144	Crow_Creek_Sioux	Dakota	Crow Creek Sioux
C44145	Flandreau_Santee	Dakota	Flandreau Santee
C44146	Lake_Traverse_Sioux	Dakota	Lake Traverse Sioux
C44147	Fort_Peck_Sioux	Nakota	Fort Peck Sioux|Fort Peck
C44148	Lower_Brule_Sioux	Lakota	Lower Brule Sioux
C44149	Lower_Sioux	Dakota	Lower Sioux
C44150	Mdewakanton_Sioux	Dakota	Mdewakanton Sioux
C44151	Miniconjou	Lakota	Miniconjou
C44152	Oglala_Sioux	Lakota	Oglala Sioux
C44153	Pine_Ridge_Sioux	Lakota	Pine Ridge Sioux
C44154	Pipestone_Sioux	Dakota	Pipestone Sioux
C44155	Prairie_Island_Sioux	Dakota	Prairie Island Sioux
C44156	Prior_Lake_Sioux	Dakota	Prior Lake Sioux
C44157	Rosebud_Sioux	Lakota	Rosebud Sioux
C44158	Sans_Arc_Sioux	Lakota	Sans Arc Sioux
C44159	Santee_Sioux	Dakota	Santee Sioux
C44160	Sisseton_Wahpeton	Dakota	Sisseton-Wahpeton
C44161	Sisseton_Sioux	Sisseton_Wahpeton	Sisseton Sioux
C44162	Wahpeton_Sioux	Sisseton_Wahpeton	Wahpeton Sioux
C44163	Spirit_Lake_Sioux	Nakota	Spirit Lake Sioux
C44164	Standing_Rock_Sioux	Lakota	Standing Rock Sioux
C44165	Two_Kettle_Sioux	Lakota	Two Kettle Sioux
C44168	N-_5-tert-butyl-3-isoxazolyl_-N-_4-_4-pyridinyl_oxyphenyl_-Urea	Raf_Kinase_Inhibitor	N-(5-tert-butyl-3-isoxazolyl)-N-(4-(4-pyridinyl)oxyphenyl) Urea|N-(5-tert-butyl-3-isoxazolyl)-N-(4-(4-pyridinyl)oxyphenyl)urea	An orally available isoxazole urea with potential anti-tumor activity.  In preclinical trials, N-(5-tert-butyl-3-isoxazolyl)-N-(4-(4-pyridinyl)oxyphenyl)urea inhibited raf kinase, an enzyme capable of reversing the phenotype of ras-transformed cells and blocking tumor growth. (NCI)
C44169	Audit_Object	UML_Entity	Audit Object|Audit	Tracks information on the contact that creates or modifies an object.
C44170	Channel_Object	UML_Entity	Channel Object|Channel	A channel represents an independent acquisition scheme for the ImageAcquisition event, typically a wavelength. (caMAGE)
C44171	Data_Cube	UML_Entity	Data Cube	A data cube is a multidimensional representation of data which provides fast retrieval and drill down facilities. (Australian Institute of Health and Welfare)
C44172	Bio_Event	UML_Entity	Bio Event	An abstract class to capture the concept of an event (either in the laboratory or a computational analysis). (caMAGE)
C44173	Experiment_Object	UML_Entity	Experiment Object|Experiment	The Experiment is the collection of all the BioAssays that are related by the ExperimentDesign. (caMAGE)
C44174	Ontology_Entry_Object	UML_Entity	Ontology Entry Object|Ontology Entry	A single entry from an ontology or a controlled vocabulary.  For instance, category could be 'species name', value could be 'homo sapiens' and ontology would be taxonomy database, NCBI. (caMAGE)
C44175	Parameter_Object	Conceptual_Entities	Parameter	Any factor that defines a system and determines (or limits) its performance.
C44176	Parameterizable_Object	UML_Entity	Parameterizable Object|Parameterizable	The Parameterizable interface encapsulates the association of Parameters with ParameterValues. (caMAGE)
C44177	Sex_or_Gender	General_Modifier	Sex or Gender
C44178	Parameterizable_Application	UML_Entity	Parameterizable Application	The interface that is the use of a Parameterizable class. (caMAGE)
C44179	Parameter_Value	UML_Entity	Parameter Value	The value of a Parameter. (caMAGE)
C44180	Physical_Array_Design_Object	UML_Entity	Physical Array Design Object	A design that is expected to be used to manufacture physical arrays. (caMAGE)
C44181	Physical_Bioassay_Object	UML_Entity	Physical Bioassay Object|Physical Bioassay	A bioAssay created by the bioAssayCreation event (e.g. in gene expression analysis this event is represented by the hybridization event). (caMAGE)
C44182	Position_Delta	UML_Entity	Position Delta	The delta the feature was actually printed on the array from the position specified for the feature in the array design. (caMAGE)
C44183	Present_Absent_Object	UML_Entity	Present/Absent Object|Present Absent|Present/Absent	Indicates relative presence or absence.  From the enumeration AbsoluteCallTypeEnum (Present / Absent / Marginal / No call) or ComparisonCallTypeEnum (Increase / Marginal Increase / Decrease / Marginal Decrease / No change / No Call / Unknown), as specified by the dataType. (caMAGE)
C44184	Protocol_Application_Object	UML_Entity	Protocol Application Object|Protocol Application	The use of a protocol with the requisite Parameters and ParameterValues. (caMAGE)
C44185	P-Value	Value	P-Value|P Value	A measure of the probability that a result happened by chance. The lower the p-value, the more likely it is that the result was caused by treatment.
C44186	Quantitation_Type_Dimension	UML_Entity	Quantitation Type Dimension	An ordered list of quantitationTypes.
C44187	Upper_Sioux	Dakota	Upper Sioux
C44188	Wahpekute_Sioux	Dakota	Wahpekute Sioux
C44189	Wazhaza_Sioux	Dakota	Wazhaza Sioux
C44190	Yankton_Sioux	Nakota	Yankton Sioux
C44191	Yanktonai_Sioux	Nakota	Yanktonai Sioux
C44192	Siuslaw	American_Indian	Siuslaw
C44193	Spokane	American_Indian	Spokane
C44194	Stewart	American_Indian	Stewart
C44195	Stockbridge	American_Indian	Stockbridge
C44196	Susanville	American_Indian	Susanville
C44197	Tohono_O_Odham	American_Indian	Tohono O'Odham
C44198	Ak_Chin	Tohono_O_Odham	Ak-Chin
C44199	Gila_Bend	Tohono_O_Odham	Gila Bend
C44200	San_Xavier	Tohono_O_Odham	San Xavier
C44201	Sells	Tohono_O_Odham	Sells
C44202	Tolowa	American_Indian	Tolowa
C44203	Tonkawa	American_Indian	Tonkawa
C44204	Tygh	American_Indian	Tygh
C44205	Umatilla	American_Indian	Umatilla
C44206	Umpqua	American_Indian	Umpqua
C44207	Cow_Creek_Umpqua	Umpqua	Cow Creek Umpqua
C44208	Ute	American_Indian	Ute
C44209	Allen_Canyon	Ute	Allen Canyon
C44210	Uintah_Ute	Ute	Uintah Ute
C44211	Ute_Mountain_Ute	Ute	Ute Mountain Ute
C44212	Wailaki	American_Indian	Wailaki
C44213	Walla_Walla	American_Indian	Walla-Walla
C44214	Wampanoag	American_Indian	Wampanoag
C44215	Gay_Head_Wampanoag	Wampanoag	Gay Head Wampanoag
C44216	Mashpee_Wampanoag	Wampanoag	Mashpee Wampanoag
C44217	Warm_Springs	American_Indian	Warm Springs
C44218	Wascopum	American_Indian	Wascopum
C44219	Washoe	American_Indian	Washoe
C44220	Alpine	Washoe	Alpine
C44221	Carson	Washoe	Carson
C44222	Dresslerville	Washoe	Dresslerville
C44223	Wichita	American_Indian	Wichita
C44224	Wind_River	American_Indian	Wind River
C44225	Winnebago	American_Indian	Winnebago
C44226	Ho_Chunk	Winnebago	Ho-Chunk
C44227	Nebraska_Winnebago	American_Indian	Nebraska Winnebago
C44228	Winnemucca	American_Indian	Winnemucca
C44229	Wintun	American_Indian	Wintun
C44230	Wiyot	American_Indian	Wiyot
C44231	Table_Bluff	Wiyot	Table Bluff
C44232	Yakama	Yakama_Cowlitz	Yakama
C44233	Yakama_Cowlitz	American_Indian	Yakama Cowlitz
C44234	Yaqui	American_Indian	Yaqui
C44235	isa_Relationship	Concept_Relationship	isa Relationship|Is-A|Parent-Child Relationship|isa	A relationship of specialization that states that a concept is a particular kind of another concept. This relationship relates concepts through logical hierarchy and forms the foundation of a taxonomy.
C44236	Barrio_Libre	Yaqui	Barrio Libre
C44237	Pascua_Yaqui	Yaqui	Pascua Yaqui
C44238	Yavapai_Apache	American_Indian	Yavapai Apache
C44239	Yokuts	American_Indian	Yokuts
C44240	Chukchansi	Yokuts	Chukchansi
C44241	Tachi	Yokuts	Tachi
C44242	Tule_River	Yokuts	Tule River
C44243	Traverse_Down	UML_Entity	Traverse Down	Specifies the default behavior of a tree search or traversal.
C44244	Yuchi	American_Indian	Yuchi
C44245	Yuman	American_Indian	Yuman
C44246	Cocopah	Yuman	Cocopah
C44247	Havasupai	Yuman	Havasupai
C44248	Hualapai	Yuman	Hualapai
C44249	Maricopa	Yuman	Maricopa
C44250	Mohave	Yuman	Mohave
C44251	Quechan	Yuman	Quechan
C44252	Yurok	American_Indian	Yurok
C44253	Coast_Yurok	Yurok	Coast Yurok
C44254	Alaskan_Athabascan	Alaska_Indian	Alaskan Athabascan
C44255	Reporter_Object	UML_Entity	Reporter Object|Reporter	A Design Element that represents some biological material (clone, oligo, etc.) on an array which will report on some biosequence or biosequences.  The derived data from the measured data of its Features represents the presence or absence of the biosequence or biosequences it is reporting on in the BioAssay.  Reporters are Identifiable and several Features on the same array can be mapped to the same reporter as can Features from a different ArrayDesign.  The granularity of the Reporter's independence is dependent on the technology and the intent of the ArrayDesign.  Oligos using mature technologies can in general be assumed to be safely replicated on many features where as with PCR Products there might be the desire for quality assurence to make reporters one to one with features and use the mappings to CompositeSequences for replication purposes.
C44256	Ratio	Conceptual_Entities	Ratio	The relative magnitudes of two quantities (usually expressed as a quotient).
C44257	Southeast_Alaska	Alaska_Indian	Southeast Alaska
C44258	Unit_of_Quantity	Unit_by_Category	Unit of Quantity|Quantity Unit	An indication of the type of unit of measure being used to express a quantity.
C44259	Tlingit_Haida	Southeast_Alaska	Tlingit-Haida|Tlinit-Haida
C44260	Reporter_Composite_Map	UML_Entity	Reporter Composite Map	A ReporterCompositeMap is the description of how source Reporters are transformed into a target CompositeSequences.  For instance, several reporters that tile across a section of a chromosome could be mapped to a CompositeSequence. (caMAGE)
C44261	Tsimshian	Southeast_Alaska	Tsimshian
C44262	Reporter_Dimension	UML_Entity	Reporter Dimension	Specialized DesignElementDimension to hold Reporters. (caMAGE)
C44263	Metlakatla	Tsimshian	Metlakatla
C44265	Greenland_Eskimo	Eskimo	Greenland Eskimo
C44266	Reporter_Group	UML_Entity	Reporter Group	Allows specification of the type of Reporter Design Element. (caMAGE)
C44267	Reporter_Position	UML_Entity	Reporter Position	The location in the composite target's sequence to which a source reporter maps.  The association to MismatchInformation allows the specification, usually for control purposes, of deviations from the CompositeSequence's BioMaterial. (caMAGE)
C44268	Inupiat_Eskimo	Eskimo	Inupiat Eskimo
C44269	Siberian_Eskimo	Eskimo	Siberian Eskimo
C44270	Yupik_Eskimo	Eskimo	Yupik Eskimo
C44271	Security_Group	UML_Entity	Security Group	Groups contacts together based on their security privileges. (caMAGE)
C44272	Annotation	Document_Type	Annotation	An explanatory or critical comment that has been added to a text.
C44274	Specialized	General_Modifier	Specialized	Developed or designed for a special activity or function.
C44275	Standard	General_Modifier	Standard	Regularly and widely used.
C44276	Unit_of_Temperature	Unit_by_Category	Unit of Temperature|Temperature Unit	An indication of the type of unit of measure being used to express a temperature.
C44277	Degree_Fahrenheit	Unit_of_Temperature	Degree Fahrenheit|F	The Fahrenheit temperature scale is named after the German physicist Gabriel Fahrenheit (1686-1736), who proposed it in 1724.  In this scale, the freezing point of water is 32 degrees Fahrenheit and the boiling point is 212 degrees, placing the boiling and melting points of water 180 degrees apart. In this scale a degree Fahrenheit is 5/9ths of a kelvin (or of a degree Celsius), and minus 40 degrees Fahrenheit is equal to minus 40 degrees Celsius.
C44278	Unit	Conceptual_Entities	Unit|UNITS	A single undivided thing occurring in the composition of something else.
C44279	Unit_of_Volume	Unit_by_Category	Unit of Volume|Volume Unit	An indication of the type of unit of measure being used to express a volume.
C44280	External	General_Modifier	External	Happening or arising or located outside or beyond some limits, or especially, some surface.
C44281	Failed	General_Modifier	Failed	Having undergone failure; did not accomplish the intended purpose.
C44282	Microarray	Diagnostic_Therapeutic_and_Research_Equipment	Microarray|High-Density Microarray	A microarray is a piece of glass or plastic on which different samples have been affixed at separate locations in an ordered manner thus forming a microscopic array.  The samples are usually DNA fragments but may also be antibodies, other proteins, or tissues.
C44283	Array_Feature	UML_Entity	Array Feature|Feature	A specific position on a microarray.
C44284	Feature_Dimension	UML_Entity	Feature Dimension	Specialized DesignElementDimension to hold Features. (caMAGE)
C44285	Data_Extraction	Clinical_or_Research_Activity	Data Extraction	A process whereby specific data is taken out of a larger set of data and presented in a usable format.
C44286	Alutiiq_Aleut	Aleut	Alutiiq Aleut
C44287	Tatitlek	Alutiiq_Aleut	Tatitlek
C44288	Ugashik	Alutiiq_Aleut	Ugashik
C44289	Bristol_Bay_Aleut	Aleut	Bristol Bay Aleut
C44290	Chugach_Aleut	Aleut	Chugach Aleut
C44291	Feature_Information	UML_Entity	Feature Information	As part of the map information, allows the association of one or more differences in the BioMaterial on a feature from the BioMaterial of the Reporter.  Useful for control purposes such as in Affymetrix probe pairs. (caMAGE)
C44295	_1_2_3-Trichloropropane	Carcinogenic_Chlorinated_Hydrocarbon	1,2,3-Trichloropropane|Allyl Trichloride|Glycerol Trichlorohydrin	A synthetic, colorless to light yellow liquid that is soluble in polar organic solvents and only slightly soluble in water. 1,2,3-Trichloropropane is used as both a chemical intermediate and cross-linking agent in the production of polymers. 1,2,3-Trichloropropane is flammable and, when heated to decomposition, emits toxic fumes of hydrogen chloride. Exposure of humans to 1,2,3-trichloropropane vapor causes irritation of the eyes and throat. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44296	_1_3-Dichloropropene	Carcinogenic_Chlorinated_Hydrocarbon	1,3-Dichloropropene|1,3-Dichloro-1-propene|1,3-Dichloropropylene	A synthetic, flammable, colorless liquid that is relatively insoluble in water and soluble in ether, acetone, toluene and benzene. It is used as an intermediate in the manufacture of 3,3-dichloro-1-propene and other pesticides. When heated to decomposition, 1,3-dichloropropene produces toxic fumes of hydrochloric acid and other chlorinated compounds. The primary routes of exposure are inhalation of vapors, dermal contact, and ingestion of contaminated foods and drinking water. Acute exposure can cause irritation of the eyes, skin and mucous membranes. Inhale a low concentration of vapors can result in irritation of the respiratory tract and central nervous system depression. Breathing higher vapor concentrations of this substance may cause coughing, breathing difficulties, substernal pain and extreme respiratory distress. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44297	_1_4-Dichlorobenzene	Carcinogenic_Chlorinated_Hydrocarbon	1,4-Dichlorobenzene|1,4-Dichlor-B|PDB|Parazene|p-Chlorophenyl Chloride|p-DCB|p-Dichlorobenzene|p-Dichlorobenzol|para-DCB	A synthetic, white crystalline solid that is practically insoluble in water and soluble in ether, chloroform, carbon disulfide, benzene, alcohol and acetone. It is used primarily as a space deodorant in products such as room deodorizers, urinal and toilet bowl blocks, and as an insecticide fumigant for moth control. When 1,4-dichlorobenzene is heated to decomposition, toxic gases and vapors (such as hydrochloric acid and carbon monoxide) are released. The primary route of potential human exposure to this compound is inhalation. Acute inhalation exposure to 1,4-dichlorobenzene can result in coughing and breathing difficulties. Breathing high levels of this chemical can cause headaches, dizziness and liver damage. Contact with 1,4-dichlorobenzene can irritate the eyes, leading to burning and tearing. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44298	_1_4-Dioxane	Cyclic_Ether_Carcinogen	1,4-Dioxane|1,4 Diethylene Ether|1,4-Diethylene Dioxide|Dioxyethylene Ether|Tetrahydro-p-dioxin	A synthetic, volatile, colorless liquid that is miscible with water, most organic solvents, aromatic hydrocarbons and oils. It is used primarily as a stabilizer in chlorinated solvents. 1,4-Dioxane is also used as a solvent for numerous commercial products and as a wetting/dispersing agent in textile processing. In research, it is used in certain biological procedures such as liquid scintillation counting and the preparation of histological sections for microscopic examination. The primary routes of potential human exposure to 1,4-dioxane are inhalation, ingestion and dermal contact. Acute exposure to low levels of 1,4-dioxane vapors causes eye and nose irritation. Exposure to very high levels of these vapors can result in liver and kidney damage and death. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44299	_1_6-Dinitropyrene	Nitroarene_Carcinogen	1,6-Dinitropyrene	A synthetic, yellow crystalline solid that is insoluble in water and moderately soluble in toluene. It is not used for any commercial applications and is used only for research purposes. When heated to decomposition, 1,6-dinitropyrene emits toxic fumes of nitrogen oxides. 1,6-dinitropyrene is found in particulate emissions from combustion products, of which diesel exhaust is the principle source. The primary route of potential human exposure to this chemical is inhalation. 1,6-dinitropyrene has been detected at low concentrations in ambient air. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44300	_1_8-Dinitropyrene	Nitroarene_Carcinogen	1,8-Dinitropyrene	A synthetic, yellow crystalline solid that is insoluble in water and moderately soluble in toluene. It is not used for any commercial applications and is used only for research purposes. When heated to decomposition, 1,8-dinitropyrene emits toxic fumes of nitrogen oxides. 1,8-dinitropyrene is found in particulate emissions from combustion products, of which diesel exhaust is the principle source. The primary route of potential human exposure to this chemical is inhalation. Detectable levels of 1,8-dinitropyrene have been found in respirable particulates from ambient atmospheric samples. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44301	_1-Amino-2_4-Dibromoanthraquinone	Carcinogenic_Anthraquinone	1-Amino-2,4-dibromoanthraquinone|1-Amino-2,4-dibromo-9,10-anthracenedione|2,4-Dibromo-1-anthraquinonylamine|CI-55458	A synthetic, light sensitive, red powder that is insoluble in water and soluble in many organic solvents. It is used as both an intermediate for the production of anthraquinone dyes and as a starting material for the manufacture of vat dyes. The primary route of potential human exposure to 1-amino-2,4-dibromoanthraquinone is dermal contact. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44302	_1-Amino-2-Methylanthraquinone	Carcinogenic_Anthraquinone	1-Amino-2-methylanthraquinone|1-Amino-2-methyl-9,10-anthracenedione|2-Methyl-1-anthraquinonylamine|Acetate Fast Orange R|Acetoquinone Light Orange JL|Artisil Orange 3RP|C.I. 60700|C.I. Disperse Orange 11|Celliton Orange R	A synthetic, red powder that is insoluble in water and soluble in acetone, ethanol, ether, benzene, chloroform and acetic acid. It is used almost exclusively as a dye and dye intermediate for the production of a variety of anthraquinone dyes. The primary routes of potential human exposure to 1-amino-2-methylanthraquinone are inhalation and dermal contact. However, human exposure is limited because this compound is no longer produced in the United States. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44303	_2_3-Dibromo-1-Propanol	Carcinogenic_Brominated_Hydrocarbon	2,3-Dibromo-1-propanol|1,2-Dibromopropan-3-ol|2,3-Dibromopropyl Alcohol|Allyl Alcohol Dibromide|DBP|Dibromopropanol|Glycerol 1,2-Dibromohydrin|beta-Dibromohydrin	A synthetic, colorless liquid that is soluble in water, alcohol, ether, benzene and acetone. It is used as an intermediate in the production of flame retardants, insecticides and pharmaceuticals. The primary routes of potential human exposure to 2,3-dibromo-1-propanol are inhalation and dermal contact. Currently, exposure of humans to this chemical is limited to workers who are exposed in an occupational setting. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44304	_2_4_6-Trichlorophenol	Carcinogenic_Chlorinated_Hydrocarbon	2,4,6-Trichlorophenol|Dowiside 2S|Omal|Phenachlor|TCP	A synthetic, colorless crystalline solid that is slightly soluble in water and soluble in organic solvents. It has been used primarily in pesticide formulations and as a wood preservative, although most uses have been cancelled in the US. When heated to decomposition, 2,4,6-trichlorophenol emits toxic and corrosive fumes of hydrochloric acid and other toxic gases. Exposure of humans to 2,4,6-trichrophenol via inhalation has been reported to cause respiratory effects, altered pulmonary function and pulmonary lesions. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44305	_2_4-Diaminoanisole_Sulfate	Organo-sulfur_Carcinogen	2,4-Diaminoanisole Sulfate|1,3-Diamino-4-methoxybenzene Sulphate|2,4-DAA Sulphate|4-Methoxy-1,3-benzenediamine Sulfate|C.I. 76051|p-Methoxy-m-phenylene-diamine Sulphate	A synthetic, off-white to violet solid that is soluble in water and ethanol. It is used primarily as a component of oxidizing 'permanent' hair- and fur-dye formulations. 2,4-Diaminoanisole sulfate is also used as an intermediate in the production of C.I. Basic Brown 2, a dye commonly used in numerous consumer products. The primary routes of potential human exposure to 2,4-diaminoanisole sulfate are dermal contact and inhalation. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44306	_2_4-Diaminotoluene	Carcinogenic_Aromatic_Amine	2,4-Diaminotoluene|1,3-Diamino-4-methylbenzene|3-Amino-para-toluidine|4-Methyl-1,3-benzenediamine|4-Methyl-meta-phenylenediamine|Diaminotoluene	A synthetic, colorless to brown crystalline solid that is soluble in water, ethanol, ether and benzene. It is used primarily as an intermediate in the production of toluene diisocyanate, which is used to produce polyurethane. Small amounts of 2,4-diaminotoluene are also used to produce dyes for textiles, leathers, furs, and wood and biological stains. When heated to decomposition, it emits toxic fumes of nitrogen oxides. The primary routes of potential human exposure to 2,4-diaminotoluene are dermal contact and inhalation. Contact with this chemical can irritate the eyes and skin. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44308	_2-Amino-3_8-Dimethylimidazo_4_5-f_Quinoxaline	Heterocyclic_Amine_Carcinogen	2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline|3,8-Dimethyl-3H-imidazo[4,5-f]quinoxalin-2-amine|MeIQx	A synthetic, pale orange to brown crystalline solid that is soluble in dimethylsulfoxide and methanol. It is produced in small quantities for research purposes. 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline is formed naturally during the cooking of muscle-derived foods (meat and fish). Levels of this chemical produced in this manner are dependent on cooking temperature, cooking time and method of cooking (direct or indirect).  It is one of the most abundant heterocyclic amines in a typical Western diet. 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline has also been detected in processed food flavorings, beer, wine, and cigarette smoke. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44309	_2-Amino-3-Methylimidazo_4_5-f_Quinoline	Heterocyclic_Amine_Carcinogen	2-Amino-3-methylimidazo[4,5-f]quinoline|3-Methyl-3H-imidazo[4,5-f]quinolin-2-amine|IQ	A synthetic, light tan crystalline solid that is soluble in dimethylsulfoxide and methanol. It is produced in small quantities for research purposes. 2-Amino-3-methylimidazo[4,5-f]quinoline is formed naturally during the cooking of muscle-derived foods (meat and fish). Levels of this chemical produced in this manner are dependent on cooking temperature, cooking time and method of cooking (direct or indirect). 2-Amino-3-methylimidazo[4,5-f]quinoline has also been detected in processed food flavorings, beer, wine, and cigarette smoke. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44310	_2-Aminoanthraquinone	Carcinogenic_Anthraquinone	2-Aminoanthraquinone|2-Amino-9,10-anthracenedione|2-Amino-9,10-anthraquinone|AAQ|beta-Aminoanthraquinone	A synthetic, red or orange-brown needle-shaped solid that is insoluble in water and soluble in alcohol, acetone, benzene and chloroform. It is used as intermediate for the synthesis of both anthraquinone dyes and pharmaceutical products. When 2-aminoanthraquinone is heated to decomposition, it emits toxic fumes of nitrogen oxides. The primary route of potential human exposure to this chemical is dermal contact. Acute exposure of humans to 2-aminoanthraquinone can cause irritation of the eyes and skin. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44311	_2-Naphthylamine	Carcinogenic_Aromatic_Amine	2-Naphthylamine|2-Aminonaphthalene|Beta-naphthylamine|Fast Scarlet Base B	A synthetic, air-sensitive, colorless crystalline solid that is soluble in hot water, alcohol, ether and many organic solvents. Currently, it is only used in laboratory research. Because the commercial production and use of 2-naphthylamine are banned, the potential for human exposure is low. The general population may be exposed to this chemical through inhalation of emissions from sources where nitrogen-containing organic matter is burned, such as coal furnaces and cigarettes. At greatest risk of occupational exposure to 2-naphthylamine are laboratory technicians and scientists who use it in research. Acute inhalation exposure to high levels of 2-naphthylamine can result in methemoglobinemia, dyspnea, ataxia, hematuria, dysuria and hemorrhagic cystitis. It is known to be a human carcinogen. (NCI05)
C44312	_2-Nitroanisole	Nitro-compound_Carcinogen	2-Nitroanisole|1-Methoxy-2-nitrobenzene|o-Nitroanisole|o-Nitrophenyl Methyl Ether	A synthetic, colorless or slightly yellow liquid that is insoluble in water and soluble in most organic solvents. It is used primarily as a precursor to o-anisidine, which is used extensively in the synthesis of azo dyes. 2-Nitroanisole is also used as an intermediate for the preparation of pharmaceuticals products. The primary routes of potential human exposure to 2-nitroanisole are dermal contact, ingestion and inhalation. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44313	_2-Nitropropane	Nitro-compound_Carcinogen	2-Nitropropane|2-NP|Dimethylnitromethane|Iso-nitropropane|Sec-nitropropane	A synthetic, flammable, colorless liquid that is slightly soluble in water, and miscible with most aromatic hydrocarbons, ketones, esters, ethers and the lower carboxylic acids. It is used primarily both as a chemical intermediate and as a solvent for numerous commercial products. 2-Nitropropane is also used as a component of explosives and propellants, and in fuels for internal combustion engines. The primary routes of potential human exposure to 2-nitropropane are dermal contact, inhalation, and ingestion. Contact with this compound can cause irritation of the eyes and skin. Acute inhalation exposure to low levels of 2-nitropropane vapors can result in irritation of the respiratory tract. Breathing higher levels of this chemical may cause anorexia, nausea, vomiting and diarrhea. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44314	_3_3-Dichlorobenzidine	Carcinogenic_Aromatic_Amine	3,3-Dichlorobenzidine|3,3-Dichloro-(1,1-Biphenyl)-4,4-Diamine|Curithane C126|DCB	A synthetic, light-sensitive, gray to purple crystalline solid that is insoluble in cold water but is soluble in ether, benzene, glacial acetic acid and alcohol. It is used primarily in the manufacture of pigments for printing ink, textiles, paper, paint, rubber, and plastics and as a curing agent for isocyanate-containing polymers and solid urethane plastics. When heated to decomposition, 3,3-dichlorobenzidine emits toxic fumes of chlorinated compounds and nitrogen oxides.  The primary routes of potential human exposure to 3,3?-dichlorobenzidine are inhalation of airborne dust, ingestion of contaminated well water by those living near hazardous waste sites, and dermal contact, primarily during industrial operations. Contact with this compound may cause dermatitis. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44315	_3_3-Dimethoxybenzidine	Retired_Concepts	3,3-Dimethoxybenzidine
C44316	_3_3-Dimethylbenzidine	Retired_Concepts	3,3-Dimethylbenzidine
C44317	_3-Chloro-2-Methylpropene	Carcinogenic_Chlorinated_Hydrocarbon	3-Chloro-2-methylpropene|2-Methylallyl Chloride|3-Chloro-2-methyl-1-propene	A synthetic, flammable, volatile, colorless to straw-colored liquid that is insoluble in water and soluble in chloroform, acetone, alcohol, ether and benzene. It is used primarily as a chemical intermediate in the production of carbofuran, a carbamate insecticide; used in the production of herbicides, plastics, pharmaceuticals, and other organic as well as an additive in textiles and perfumes. When heated to decomposition, it emits toxic fumes of hydrochloric acid and other chlorinated compounds. Contact exposure of this substance causes irritation of the eyes and skin. Inhalation can lead to irritation of the respiratory tract and depression of the central nervous system. Breathing at high levels of 3-chloro-2-methylpropene vapors may induce coughing, gasping, breathing difficulties and extreme respiratory distress, even coma. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44318	_4-N-Nitrosomethylamino-1-3-Pyridyl-1-Butanone	Retired_Concepts	4-N-Nitrosomethylamino-1-3-Pyridyl-1-Butanone|NNK
C44319	_4_4-Methylenebis_2-Chloroaniline	Carcinogenic_Aromatic_Amine	4,4-Methylenebis,2-Chloroaniline|2,2'-Dichloro-4,4'-methylenedianiline|4,4'-Methylene(bis)chloroaniline|4,4'-Methylenebis(2-chlorobenzeneamine)|DACPM|MBOCA|di(4-Amino-3-chlorophenyl)methane	A tan-colored, solid, chlorinated aromatic amine with an amine-like odor that emits toxic fumes of hydrochloric acid and other chlorinated compounds when heated to decomposition. 4,4-Methylenebis-2-chloroaniline is primarily used in industry as a curing agent for liquid polyurethane elastomers and is used as an experimental carcinogen in research. Exposure to this substance can cause gastrointestinal distress and severe irritation of the face and eyes. 4,4-Methylenebis-2-chloroaniline is reasonably anticipated to be a human carcinogen and may be associated with an increased risk of developing bladder cancer. (NCI05)
C44320	_4_4-Methylenedianiline	Carcinogenic_Aromatic_Amine	4,4-Methylenedianiline|4,4'-Methylenebisbenzenamine	A yellowish to brownish colored crystalline solid aromatic amine with a faint amine-like odor that is unstable in the presence of light or air and emits toxic fumes of aniline and nitrogen oxides when heated to decomposition. 4,4'-Methylenedianiline is primarily used in industry as a chemical intermediate in the production of 4,4-methylenedianiline diisocyanates and polyisocyanates, but is also used as a cross-linking agent for the determination of tungsten and sulfates, and as a corrosion inhibitor. Exposure to this substance irritates the skin and eyes and causes liver damage. 4,4'-Methylenedianiline is reasonably anticipated to be a human carcinogen. (NCI05)
C44321	_4_4-Oxydianiline	Carcinogenic_Aromatic_Amine	4,4-Oxydianiline|4,4'-DADPE|4,4'-Diaminodiphenyl Ether|4-Aminophenyl Ether|DADPE|ODA|bis(4-Aminophenyl) Ether|p-Aminophenyl Ether	A colorless, odorless, combustible aromatic amine that emits toxic fumes of nitrogen oxides when heated to decomposition. 4,4'-Oxydianiline is used in industry in the manufacture of polyimide and polyester resins. Exposure to this substance is irritating to the eyes, skin and respiratory-tract. 4,4'-Oxydianiline is reasonably anticipated to be a human carcinogen. (NCI05)
C44322	_4_4-Thiodianiline	Carcinogenic_Aromatic_Amine	4,4-Thiodianiline|4,4'-Diaminodiphenylsulfide|4,4'-Thiobis-benzenamine	A brown to violet colored solid aromatic amine that emits toxic fumes of nitrogen oxides, carbon monoxide, carbon dioxide, nitrogen and sulfur oxides when heated to decomposition. 4,4'-Thiodianiline is primarily used as a chemical intermediate in the production of certain dyes. Exposure to this substance is irritating to the respiratory tract and can result in methemoglobinemia causing headache, dizziness, weakness and can lead to shortness of breath, collapse and even death. 4,4'-Thiodianiline is a possible mutagen and is reasonably anticipated to be a human carcinogen. (NCI05)
C44323	_4-Chloro-Ortho-Phenylenediamine	Carcinogenic_Aromatic_Amine	4-Chloro-ortho-phenylenediamine|1,2-Diamine-4-chlorobenzene|1-Chloro-3,4-diaminebenzene|2-Amino-4-chloroaniline|3,4-Diaminochlorobenzene|4-Chloro-1,2-phenylenediamine|CI 76015|Ursol Olive 6g|p-Chloro-1,2-phenylenediamine	A synthetic, beige to grey-brown crystalline powder that is slightly soluble in water, soluble in benzene and petroleum ether, and very soluble in ethanol and diethyl ether. It is used as an oxidative base, a chemical intermediate to produce 5-chlorobenzotriazole (an isomer which is a photographic chemical), a curing agent for epoxy resins and a reagent in gas chromatography. The primary routes of potential human exposure to 4-chloro-o-phenylenediamine are ingestion, inhalation, and dermal contact during its production. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44324	_4-Dimethylaminoazobenzene	Carcinogenic_Aromatic_Amine	4-Dimethylaminoazobenzene|C.I. 11020|C.I. Solvent Yellow 2|DAB|DMAB|Dimethylaminoazobenzol|Methyl Yellow|N,N-Dimethyl-4-(phenylazo)benzenamine|N,N-Dimethyl-4-aminoazobenzene|N,N-dimethyl-p-phenylazoaniline|p-Dimethylaminoazobenzene	A yellow, crystalline solid compound. 4-Dimethylaminoazobenzene was used as a dye for coloring polishes, wax products, polystyrene and soap, and was also used as a pH indicator, but is no longer used or produced in the United States. Exposure to this substance causes dermatitis. 4-dimethylaminoazobenzene is reasonably anticipated to be a human carcinogen. (NCI05)
C44325	_4-Nitropyrene	Nitroarene_Carcinogen	4-Nitropyrene	A synthetic, orange needle-shaped solid that is that is practically insoluble in water and soluble in diethyl ether, acetone, ethanol, benzene and toluene. It is not used for any commercial applications and is used only for research purposes. When heated to decomposition, 4-nitropyrene emits toxic fumes of nitrogen oxides. 4-Nitropyrene is found in particulate emissions from combustion products, of which diesel exhaust is the principle source. The primary route of potential human exposure to 4-nitropyrene is inhalation. Low concentrations of 6-nitrochrysene have been found in ambient airborne particulates. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44326	_4-Vinyl-1-Cyclohexene_Diepoxide	Carcinogenic_Epoxide	4-Vinyl-1-cyclohexene Diepoxide|1-Epoxyethyl-3,4-epoxycyclohexane|1-Vinyl-3-cyclohexene Dioxide|3-(1,2-Epoxyethyl)-7-oxabicyclo(4.1.0)heptane|3-Oxiranyl-7-oxabicyclo[4.1.0]heptane,|4-Vinyl-1-cyclohexene Dioxide	A synthetic, colorless liquid that is soluble in water. It is used as a reactive diluent for other epoxides and as a monomer in the production of epoxy resins for coatings and adhesives. Occupational exposure of humans to 4-vinyl-1-cyclohexene diepoxide results in skin irritation. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44327	_7H-Dibenzo_c_g_Carbazole	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	7H-Dibenzo[c,g]carbazole|3,4,5,6-Dibenzocarbazole|7-Aza-7H-dibenzo(c,g)fluorene	A crystalline, carcinogenic aromatic hydrocarbon consisting of five fused rings and produced during the incomplete combustion of organic matter. 7H-Dibenzo[c,g]carbazole is primarily found in cigarette tar. This substance is used only for research purposes. 7H-Dibenzo[c,g]carbazole is reasonably anticipated to be a human carcinogen. (NCI05)
C44328	Acetaldehyde	Organic_Carcinogen	Acetaldehyde|Acetic Aldehyde|Acetylaldehyde|Ethanal|Ethyl Aldehyde	A widespread, naturally occurring, colorless and flammable liquid with a suffocating smell. Acetaldehyde is found in various plants, ripe fruits, vegetables, cigarette smoke, gasoline and diesel exhaust. This substance is widely used in the manufacture of acetic acid, perfumes, dyes and drugs, as a flavoring agent and as an intermediate in the metabolism of alcohol. Acute exposure to its vapors results in irritation of the eyes, skin, and respiratory tract. Acetaldehyde is reasonably anticipated to be a human carcinogen. (NCI05)
C44329	Acrylamide	Organo-nitrogen_Carcinogen	Acrylamide|2-Propenamide|Ethylene Carboxamide|Propenoic Acid Amide|Vinyl Amide	A colorless, odorless, crystalline amide that polymerizes rapidly and can form as a byproduct during the heating of starch-rich foods to high temperatures. Acrylamide is used in the production of polymers mainly in the water treatment industry, pulp and paper industry and textile treatment industry and is used as a laboratory reagent. The polymer is nontoxic, but exposure to the monomer can cause central and peripheral nervous system damage resulting in hallucinations, drowsiness and numbness in the hands and legs. Acrylamide is reasonably anticipated to be a human carcinogen. (NCI05)
C44330	a-Hexachlorocyclohexane	Chlorinated_Ring_Carcinogen	a-Hexachlorocyclohexane|1a,2a,3b,4a,5b,6a-Hexachlorocyclohexane|a-1,2,3,4,5,6-Hexachlorocyclohexane|a-Benzene Hexachloride|a-HCH|a-Lindane	A brownish-white colored, sand-like powder with a phosgene-like odor that emits toxic fumes of phosgene gas, hydrochloric acid and other chlorinated compounds when heated to decomposition. a-Hexachlorocyclohexane is the alpha-isomer of hexachlorocyclohexane and is used as an insecticide to treat lice and scabies. Inhalation exposure to this substance causes severe irritation of the nose, throat and lungs; causes anemia, and affects the liver, kidneys, nervous system, cardiovascular system and immune system. a-Hexachlorocyclohexane is reasonably anticipated to be a human carcinogen. (NCI05)
C44331	Amitrole	Carcinogenic_Aromatic_Amine	Amitrole|1H-1,2,4-Triazol-3-Amine|3-Amino-1,2,4-Triazole|ATA|Aminotriazole|Amizol|Cytrol|ENT 25445	A colorless, odorless crystalline, aromatic amine with a bitter taste. Amitrole is a widely used herbicide for nonfood croplands to control annual and perennial grass type weeds, pondweeds and broad leaf. This substance has a very low acute toxicity in humans and is characterized by skin rash, diarrhea, nausea, vomiting and nose bleeds. Amitrole is reasonably anticipated to be a human carcinogen. (NCI05)
C44332	Basic_Fuchsin	Carcinogenic_Aromatic_Amine	Basic Fuchsin|4,4'-[(4-Imino-2,5-cyclohexadien-1-ylidene)methylene]bisbenzenamine Monohydrochloride|4-[(4-Aminophenyl)(4-imino-2,5-cyclohexadien-1-ylidene)methyl]-benzenamine, Monohydrochloride|Basic Parafuchsin|C.I. 42500|C.I. Basic Red 9|C.I.Basic Red 9 Monohydrochloride|Calcozine Magenta N|Fuchsine DR 001|Fuchsine SPC|Orient Para Magenta Base|Para Magenta|Pararosaniline|p-Fuchsin|p-Rosaniline Hydrochloride	A green, crystalline, solid dye that is one of the major components of magenta. Basic fuchsin is primarily used for bacterial identification, but is also used as a dye in textiles, leather, and printing inks. Exposure to basic fuchsin is irritating to the eyes and skin. The substance is reasonably anticipated to be a human carcinogen. (NCI05)
C44333	BBMP	Organo-halide_Carcinogen	BBMP|2,2-bis(Bromomethyl)-1,3-Propanediol|FR-1138	A solid, white, organo-halide carcinogen with a musty odor that consists for 78% of 2,2-Bis(Bromomethyl)-1,3-Propanediol. BBMP is used in industry as a flame retardant in unsaturated polyester resins, in molded products and in rigid polyurethane foam. BBMP is mutagenic and carcinogenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05)
C44334	Benz_a_anthracene	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	Benz[a]anthracene|1,2-Benz(a)anthracene|1,2-Benzoanthracene|2,3-Benzophenanthrene|2,3-Benzphenanthrene|BA|Benz(b)phenanthrene|Benzanthrene|Benzoanthracene|Naphthanthracene|Tetraphene	A crystalline, aromatic hydrocarbon consisting of four fused benzene rings, produced by incomplete combustion of organic matter. Benz(a)anthracene is primarily found in gasoline and diesel exhaust, tobacco and cigarette smoke, coal tar and coal tar pitch, coal combustion emissions, charcoal-broiled foods, amino acids, fatty acids and carbohydrate pyrolysis products, wood and soot smoke, and creosote, asphalt and mineral oils. This substance is used only for research purposes. Benz(a)anthracene is reasonably anticipated to be a human carcinogen. (NCI05)
C44335	Benzidine	Carcinogenic_Aromatic_Amine	Benzidine|4,4'-Diamonophenyl|4,4'-Diphenylenediamine|Fast Corinth Base B|p-Benzidine|p-Diaminodiphenyl	A grayish-red, yellowish or white colored, very toxic, crystalline aromatic amine that darkens when exposed to air and light. Benzidine has been widely used for the detection of blood and as a reagent in the manufacture of dyes. Ingestion of benzidine causes cyanosis, headache, mental confusion, nausea and vomiting. Its use is now limited because of strong association between exposure to benzidine and an increased risk of bladder cancer in humans. (NCI05)
C44336	Benzo_j_fluoranthene	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	Benzo[j]fluoranthene|10,11-Benzofluoranthene|7,8-Benzofluoranthene|B(j)F|Benzo(l)fluoranthene|Benzo-12,13-fluoranthene|Dibenzo(a,jk)fluorene	A yellowish, aromatic hydrocarbon consisting of five fused rings and formed by the incomplete combustion of organic matter. Benzo(j)fluoranthene is primarily found in certain foods, cigarette smoke, gasoline exhaust, coal tar, coal smoke, oil heat emissions, crude oils and used motor oils. This substance is used only for research purposes. Benzo(j)fluoranthene is reasonably anticipated to be a human carcinogen. (NCI05)
C44337	Benzo_k_fluoranthene	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	Benzo[k]fluoranthene|11,12-Benzo[k]fluoranthene|2,3,1',8'-Binapthylene|8,9-Benzofluorathene|B(K)F|BKF|Dibenzo(b,jk)fluorene	A pale yellow aromatic hydrocarbon consisting of five fused rings and is produced by the incomplete combustion of organic matter. Benzo(k)fluoranthene is primarily found in gasoline exhaust, cigarette smoke, coal tar, coal and oil combustion emissions, lubricating oils, used motor oils and crude oils. This substance is used only for research purposes. Benzo(k)fluoranthene is reasonably anticipated to be a human carcinogen. (NCI05)
C44338	Beryllium	Carcinogenic_Metal|Metals	Beryllium|Be|Beryllium Metal|Beryllium Powder	AN element with atomic symbol Be, atomic number 4, and atomic weight 9.01
C44339	Beta-Propiolactone	Cyclic_Ether_Carcinogen	Beta-Propiolactone|2-Oxetanone|3-Hydroxypropionic Acid, b-Lactone|3-Propanolide|3-Propiolactone|Hydracrylic Acid, b-Lactone|b-Propionolactone	A colorless, highly reactive, liquid, cyclic ether with a slightly sweet odor. Beta-propiolactone was used once mainly in the manufacture of acrylic acid and esters. It also was used as a sterilant for medical materials and procedures. However, it is no longer used for medical disinfection. Dermal exposure to beta-propiolactone causes the burning or blistering of the skin, and ingestion of this substance burns the mouth and stomach while exposure to its vapors causes severe irritation of the eyes, throat and respiratory tract. This substance is reasonably anticipated to be a human carcinogen. (NCI05)
C44340	b-Hexachlorocyclohexane	Chlorinated_Ring_Carcinogen	b-Hexachlorocyclohexane|1a,2b,3a,4b,5a,6b-Hexachlorocyclohexane|b-Benzene Hexachloride|b-HCH|b-Hexachlorobenzene|b-Lindane	A colorless, sand-like powder that emits toxic fumes of phosgene gas, hydrochloric acid and other chlorinated compounds when heated to decomposition. b-Hexachlorocyclohexane is the beta-isomer of hexachlorocyclohexane and is used as an insecticide. Inhalation exposure to this substance causes severe irritation of the nose, throat, and lungs; causes anemia, and affects the liver, kidneys, nervous system, cardiovascular system and immune system. b-Hexachlorocyclohexane is reasonably anticipated to be a human carcinogen. (NCI05)
C44341	Bis_2-Ethylhexyl_Phthalate	Organic_Carcinogen	Bis(2-ethylhexyl) Phthalate|1,2-Benzenedicarboxylic Acid, Bis(2-ethylhexyl)|BEHP|Bis(2-ethylhexyl) 1,2-Benzenedicarboxylate|di(2-Ethylhexyl) Phthalate	A colorless, oily organic carcinogen with a slight odor. Bis(2-Ethylhexyl) Phthalate is mainly used as a plasticizer for fabricating flexible materials for many household products. Inhalation, digestion, and dermal contact are the primary routes of potential exposure, which was linked to increased incidence of hepatocellular carcinomas in animals. This substance is reasonably anticipated to be a human carcinogen. (NCI05)
C44342	Bis_Chloroethyl_Nitrosourea	Retired_Concepts	Bis(chloroethyl) Nitrosourea|1,3-Bis(2-chloroethyl)-1-nitrosourea|1,3-Bis(beta-chloroethyl)-1-nitrosourea|BCNU|BiCNU|Carmubris|Carmustin|FDA 0345|N,N'-bis(2-chloroethyl)-N-nitrosourea|Nitrumon|SK 27702|SRI 1720
C44343	Bis_Chloromethyl_Ether	Organo-halide_Carcinogen	Bis(chloromethyl) Ether|1,1'-Dichlorodimethyl Ether|BCME|BRN 1679223|Bis-CME|CCRIS 90|Dichlorodimethyl Ether|Dichloromethyl Ether|Oxybis(chloromethane)	A colorless, flammable, carcinogenic liquid with an extremely suffocating odor. Bis(Chloromethyl) Ether is used in industry as an alkylating agent, a chemical intermediate, a monitoring indicator for the presence of chloromethyl ether, and as a laboratory reagent. This substance is irritating to eyes and mucous membranes and emits toxic vapors of hydrochloric acid and other chlorinated compounds when heated to decomposition. Exposure to Bis(Chloromethyl) ether is associated with higher risk of developing lung cancer, mainly small-cell type, and the risk increases with increasing duration and cumulative exposure. (NCI05)
C44344	Broad-Spectrum_UV_Radiation	Ultraviolet_Radiation	Broad-Spectrum UV Radiation
C44345	Bromodichloromethane	Carcinogenic_Brominated_Hydrocarbon|Carcinogenic_Chlorinated_Hydrocarbon	Bromodichloromethane|BDCM|Monobromodichloromethane|NCI-C55243	A colorless, liquid halogenated hydrocarbon. Bromodichloromethane is used in the synthesis of chemicals and as a reagent in laboratory research. This substance is also found as a by-product in chlorinated water. Bromodichloromethane is reasonably anticipated to be a human carcinogen. (NCI05)
C44346	Bromoethene	Carcinogenic_Brominated_Hydrocarbon	Bromoethene|Bromoethylene|Monobromoethylene|Vinyl Bromide	A colorless, highly flammable gas of brominated hydrocarbon, with a characteristic pungent odor. Bromoethene is mainly used in the production of polymers and copolymers for rubber, plastic, leather and fabricated metal production. Exposure to bromoethene causes dizziness, disorientation, sleepiness. Chronic exposure causes liver and kidney damage. Its metabolites, via cytochrome P450 oxidation, are potent alkylating agents and causes DNA adducts, which is responsible for the carcinogenic effect. Bromoethene is reasonably anticipated to be a human carcinogen. (NCI05)
C44347	Butylated_Hydroxyanisole	Organic_Carcinogen	Butylated Hydroxyanisole|(1,1-Dimethylethyl)-4-methoxyphenol|2(3)-Tert-butyl-4-hydroxyanisole|Antioxyne B|BHA|BOA|Tert-butyl-4-methoxyphenol	A white, waxy solid mixture of 2- and 3-Tert-butyl-4-hydroxyanisole with a faint aromatic odor. Butylated Hydroxyanisole is a widely used synthetic antioxidant in foods, cosmetics and pharmaceuticals mainly to preserve fats and oils. Butylated Hydroxyanisole is reasonably anticipated to be a human carcinogen. (NCI05)
C44348	Cadmium	Carcinogenic_Metal|Metals	Cadmium|Cadmium Metal|Cd	An element with atomic symbol Cd, atomic number 48, and atomic weight 112.4.
C44349	Cadmium_Compound	Carcinogenic_Metal	Cadmium Compound	An inorganic substance that contains the metallic element cadmium usually in its positive-2 valence state and forms toxic fumes of cadmium oxide when heated. Cadmium compounds are used in industry in electroplating and coating, in pigments, in batteries, in alloys, and as stabilizers. Exposure to these substances affects the lungs and kidneys and is associated with an increased risk of developing lung cancer. (NCI05)
C44350	Carbon_Tetrachloride	Carcinogenic_Chlorinated_Hydrocarbon	Carbon Tetrachloride|Carbon Chloride|Carbon Tet|Freon 10|Perchloromethane|Tetrachloromethane	A clear, colorless, volatile and very stable chlorinated hydrocarbon. Carbon Tetrachloride is used as a solvent for oils and fats, as a refrigerant and as a dry-cleaning agent. Inhalation of its vapors can depress central nervous system activity and cause degeneration of the liver and kidneys. Carbon Tetrachloride is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44351	Carcinogenic_Hydrocarbon	Organic_Carcinogen	Carcinogenic Hydrocarbon	An organic compound that is likely to cause cancer and contains only carbon and hydrogen that can be arranged in rows, rings, or both, and connected by single, double or triple bonds. Carcinogenic hydrocarbons are often found in petroleum, natural gas and coal and are capable of causing cancer. (NCI05)
C44352	Chlordecone	Chlorinated_Ring_Carcinogen	Chlordecone|Compound 1189|Decachloroketone|Decachlorooctahydro-1,3,4-metheno-2H-cyclobuta(cd)-pentalen-2-one|Decachlorooctahydro-kepone-2-one|Decachlorotetracyclodecanone|Kepone	A very stable, colorless, odorless, synthetic chlorinated polycyclic hydrocarbon that is a degradation product of Mirex. Chlordecone has been used as an insecticide on bananas, non-bearing citrus trees, tobacco, lawns and flowers. Exposure to this substance causes neurological symptoms, such as tremors and slurred speech. Chlordecone is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44353	Chlorendic_Acid	Chlorinated_Ring_Carcinogen	Chlorendic Acid|1,4,5,6,7,7-Hexachloro-5-norbornene-2,3-dicarboxylic Acid|1,4,5,6,7,7-Hexachlorobicyclo(2.2.1)-5-heptene-2,3-dicarboxylic Acid|Het Acid|Hexachloroentomethylenetetrahydrophthalic Acid	A white, crystalline carcinogenic chlorinated hydrocarbon that emits toxic fumes of hydrochloric acid and other chlorinated compounds when heated to decomposition. Chlorendic acid is used as a reactive flame retardant, chemical intermediate, hardening agent and as an extreme pressure lubricant. Exposure to chlorendic acid causes skin, eye and respiratory tract irritation. Chlorendic acid is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44354	Chlorinated_Paraffin	Carcinogenic_Chlorinated_Hydrocarbon	Chlorinated Paraffin|Chlorinated Parafins (Average Chain Length, C12; Approximately 60 % Chlorine By Weight)	A yellowish, odorless, viscous, oily carcinogenic chlorinated hydrocarbon. Chlorinated paraffin is used as an extreme pressure lubricant, flame retardant and plasticizer. Chlorinated paraffins, with chain lengths of C12 and chlorine contents of 60%, are reasonably anticipated to be human carcinogens based on evidence of carcinogenicity in experimental animals. (NCI05)
C44355	Chloromethyl_Methyl_Ether	Organo-halide_Carcinogen	Chloromethyl Methyl Ether|CMME|Chlorodimethylether|Chloromethoxymethane|Dimethylchloroether|Monochloromethyl Methyl Ether	A colorless, flammable, carcinogenic liquid with a highly irritating odor. Chloromethyl methyl ether is used in the synthesis of chloromethylated compounds, as an alkylating agent, and as a solvent in the manufacture of water repellents, ion-exchange resins, and industrial polymers. Exposure to its vapors causes severe irritation of the skin, eyes, mucous membranes, respiratory tract as well as pulmonary edema, pneumonia and lung cancer (mainly small-cell type) in humans. Chloromethyl methyl ether is a known human carcinogen. (NCI05)
C44356	Chloroprene	Carcinogenic_Chlorinated_Hydrocarbon	Chloroprene|2-Chloro-1,3-butadiene|Neoprene|beta-Chloroprene	A colorless, flammable, carcinogenic, chlorinated hydrocarbon with a pungent, ethereal odor. Chloroprene is used as a chemical intermediate in the manufacture of neoprene rubber. Exposure to this substance causes damage to the skin, lungs, CNS, kidneys, liver and depression of the immune system. Chloroprene is a mutagen and carcinogen in animals and is reasonably anticipated to be a human carcinogen. (NCI05)
C44357	Chromium_Hexavalent_Compound	Carcinogenic_Metal	Chromium Hexavalent Compound|Chromium Hexavalent (VI) Compounds	A highly corrosive, inorganic substance that contains the metallic element chromium in its positive-6 valence state. Chromium hexavalent compounds are used in stainless steel production, in chrome plating, in the manufacture of dyes and pigments, in leather tanning, in wood preservation and are used as corrosion inhibitors. Inhalation exposure of these compounds mainly affects the respiratory tract causing shortness of breath, nasal itching, asthma, coughing, bronchitis and pneumonia, but can also affect the liver, kidneys, gastrointestinal tract and the immune system. Chromium hexavalent compounds are carcinogenic in humans and are associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity. (NCI05)
C44358	Coal_Tar	Carcinogenic_Mixture	Coal Tar	A dark brown or black thick liquid obtained by roasting pine wood or formed as a by-product in the production of coke. Coal tar is a complex mixture of organic substances, including benzene, phenols, sulfur, aniline, toluene, xylene, naphthalene, anthracene and phenanthrene. This substance is used to treat certain skin diseases, especially psoriasis, and is used in the synthesis of dyes, drugs, explosives, flavorings, perfumes, preservatives, synthetic resins, paints and stains. Coal tar exposure leads to an increased risk of developing cancer of skin, lung, bladder, kidney and digestive tract as well as leukemia. It is known to be a human carcinogen. (NCI05)
C44359	Coal_Tar_Pitch	Carcinogenic_Mixture	Coal Tar Pitch|Coal Tar Pitches	A shiny, dark brown to black by-product of the distillation of coal tars and contains various polycyclic aromatic hydrocarbons and their methyl and polymethyl derivatives, as well as hetero-nuclear compounds. Coal tar pitch is mainly used as a binder for aluminum smelting electrodes, but is also used in coating surfaces, in roofing materials, to impregnate and strengthen refractory brick and is used to produce pitch coke. Coal tar pitch exposure leads to an increased risk of developing skin, lung, bladder, kidney and digestive-tract cancer as well as leukemia. It is known to be a human carcinogen. (NCI05)
C44360	Cobalt_Sulfate	Carcinogenic_Salt	Cobalt Sulfate|Cobalt Monosulfate Heptahydrate|Cobalt Sulfate Heptahydrate|Cobalt Sulfate, 7-Hydrate|Cobalt(II) Sulfate Heptahydrate|Cobaltous Sulfate|Sulfuric Acid, Cobalt (2+) Salt (1:1) Heptahydrate	A reddish, toxic, metallic salt. Cobalt sulfate is used in the electrochemical industries, as a drier in paints and inks, as a coloring agent, in storage batteries and as a supplement for Vitamin B12 deficiency. Exposure to cobalt sulfate results in irritation of the skin, eyes and respiratory tract and affects the thyroid, lungs, heart and kidneys. Cobalt sulfate is mutagenic in mammalian cells and is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44361	Coke_Oven_Emission	Carcinogenic_Mixture	Coke Oven Emission	A complex mixture of dusts, vapors and gases that contains various known or potential carcinogens, including polycyclic aromatic hydrocarbons, formaldehyde, nitrosamines, coal tar and coal tar pitch, cadmium, benzene and arsenic compounds. Coke Oven Emissions are produced during the conversion of coal into coke by heating the coal in the absence of oxygen. Chronic exposure to coke oven emissions in humans results in conjunctivitis, severe dermatitis, and lesions in the respiratory and digestive-tract. Coke Oven Emissions are associated with an increased risk of developing lung, skin, kidney and bladder cancer. (NCI05)
C44362	Cupferron	Carcinogenic_Aromatic_Amine	Cupferron|Ammonium N-hydroxy-N-nitrosobenzenamine|Inhibitor NPH|N-nitroso-N-phenylhydroxylamine Ammonium Salt	A creamy, white crystalline substance. Cupferron is used as an analytical reagent to separate copper, iron and vanadium from other metals. Exposure to this substance causes gastrointestinal disturbances and skin, eye and respiratory-tract irritation. Cupferron is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44363	Danthron	Carcinogenic_Anthraquinone	Danthron|1,4,5,8-Tetroxyantraquinone|1,8-Dihydroxy-9,10-anthracenedione|1,8-Dihydroxy-9,10-anthraquinone|1,8-Dihydroxyanthraquinone|1,8-Dioxyanthraquinone|Chrysazin|Dioxyanthrachinonum	A reddish, synthetic anthraquinone derivative. Danthron has been widely used as a laxative, but is no longer used to treat constipation and is currently used as an antioxidant in synthetic lubricants, in the synthesis of experimental antitumor agents, as a fungicide and as an intermediate for making dyes. This substance is a suspected mutagen and is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44364	DDT	Carcinogenic_Chlorinated_Hydrocarbon	DDT|1,1'-(2,2,2-Trichloroethylidene)-bis[4-chlorobenzene]|1,1,1-Trichloro-2,2-bis(p-chlorophenyl)ethane|1,1-Bis(4-chlorophenyl)-2,2,2-trichloroethane|Dichlorodiphenyltrichloroethane|p,p'-DDT|p,p'-Dichlorodiphenyltrichloroethane	A white, odorless and tasteless, very stable, water-insoluble, synthetic, crystalline chlorinated hydrocarbon that is soluble in most organic solvents, fat and oils and tends to accumulate in ecosystems. DDT was once widely used as a pesticide to control insects in agriculture and to control malaria, typhus and body lice, but its use is now limited. Exposure to DDT mainly affects the nervous system resulting in tremors, dizziness, nausea, incoordination, convulsions and seizures. This substance is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44365	Dianisidine	Carcinogenic_Aromatic_Amine	Dianisidine|3,3'-Dimethoxybenzidine|3,3'-Dimethoxybenzidine Dihydrochloride|4,4'-Diamino-3,3'-dimethoxybiphenyl|Bianisidine|ortho-Dianisidine	A colorless, highly toxic, crystalline compound that turns violet when exposed to air. Dianisidine is used exclusively as an intermediate for the production of dyes and pigments. Exposure to this substance causes skin irritation and sensitization. Dianisidine is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44366	Diazoaminobenzene	Carcinogenic_Aromatic_Amine	Diazoaminobenzene|1,3-Diphenyl-1-triazene|Anilinoazobenzene|DAAB|N-(phenylazo)-aniline|p-Diazoaminobenzene	An orange crystalline solid compound that is metabolized to benzene in vivo. Diazoaminobenzene is used as a chemical intermediate, complexing agent and polymer additive and is a contaminant in several dyes used in drugs, cosmetics and foods.  Diazoaminobenzene is genotoxic in bacteria and rodents.  It is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44367	Dibenz_a_h_acridine	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	Dibenz[a,h]acridine|1,2,5,6-Dibenzacridine|1,2,5,6-Dinaphthacridine|7-Azadibenz(a,h)anthracene|DB(a,h)AC|Dibenz(a,d)acridine	A aromatic hydrocarbon consisting of five fused rings formed during the incomplete burning of organic matter. Benz[a,h]acridine is primarily found in petroleum refinery incinerator emissions, coal combustion emissions, cigarette smoke and coal tar pitch. This substance is used only for research purposes. Benzo[a,h]acridine is reasonably anticipated to be a human carcinogen. (NCI05)
C44368	Dibenz_a_j_acridine	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	Dibenz[a,j]acridine|1,2,7,8-Dibenzacridine|3,4,5,6-Dibenzacridine|3,4,6,7-Dinaphthacridine|7-Azadibenz(a,j)anthracene|DB(a,j)AC|Dibenzo(a,j)acridine	A yellowish aromatic hydrocarbon consisting of five fused rings formed by the incomplete burning of organic matter. Dibenz[a,j]acridine is primarily found in gasoline exhaust, petroleum refinery incinerator emissions, coal combustion emissions, cigarette smoke and coal tar pitch. This substance is used only for research purposes. Dibenz[a,j]acridine is reasonably anticipated to be a human carcinogen. (NCI05)
C44369	Dibenzo_a_e_pyrene	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	Dibenzo[a,e]pyrene|1,2,4,5-Dibenzopyrene|DB(a,e)P|Naphtho(1,2,3,4,def)chrysene	A yellowish-reddish, aromatic hydrocarbon consisting of six fused rings and produced by incomplete combustion of organic matter. Dibenzo[a,e]pyrene is primarily found in gasoline exhaust, tobacco smoke and fossil fuels. This substance is used only for research purposes. Dibenzo[a,e]pyrene is reasonably anticipated to be a human carcinogen. (NCI05)
C44370	Dibenzo_a_h_pyrene	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	Dibenzo[a,h]pyrene|1,2,6,7-Dibenzopyrene|DB(a,h)P|Dibenzo(b,def)chrysene	A crystalline, aromatic hydrocarbon consisting of six fused rings and formed during the incomplete combustion of organic matter. Dibenzo[a,h]pyrene is primarily found in engine exhaust, cigarette tar and coal tar pitch. Dibenzo[a,h]pyrene is reasonably anticipated to be a human carcinogen. (NCI05)
C44371	Dibenzo_a_i_pyrene	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	Dibenzo[a,i]pyrene|1,2,7,8-Dibenzopyrene|3,4,9,10-Dibenzpyrene|Benzo(rst)pentaphene|DB(a,i)P	An aromatic hydrocarbon that consists of six fused rings and is produced by the incomplete combustion of organic matter. Dibenzo[a,i]pyrene is primarily found in gasoline exhaust, tobacco smoke and coal tar. Dibenzo[a,i]pyrene is reasonably anticipated to be a human carcinogen. (NCI05)
C44372	Dibromochloropropane	Carcinogenic_Brominated_Hydrocarbon	Dibromochloropropane|1,2-Dibromo-3-chloropropane|DBCP|Fumazone|Nemafume|Nemagon|OS-1897	A dark amber to dark brown colored, halogenated liquid with a pungent odor. Dibromochloropropane is a formerly known pesticide that was used as a soil fumigant and nematocide on crops, and is currently only used as an intermediate in organic synthesis and as a research chemical. Inhalation exposure to this substance results in central nervous system depression and pulmonary edema, while oral exposure causes gastrointestinal distress. Dibromochloropropane is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44373	Diepoxybutane	Carcinogenic_Epoxide	Diepoxybutane|1,1'-Bi(ethylene Oxide)|1,2,3,4- Diepoxybutane|2,2'-Bioxirane|Butadiene Dioxide|DEB	A colorless, highly flammable, liquid cyclic ether. Diepoxybutane is primarily used for research purposes, but is also used as a curing agent for polymer resins and as a cross-linking agent for making synthetic textile fibers. Exposure to this substance can severely irritate and burn the eyes and skin and can cause liver damage. Diepoxybutane is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44374	Diesel_Exhaust_Particulate	Carcinogenic_Mixture	Diesel Exhaust Particulate|Diesel Exhaust Particulates	A complex mixture of combustion products of diesel fuel including carbon monoxide, carbon dioxide, sulfur oxides, nitrogen oxides, volatile hydrocarbons, aldehydes, alkenes, alkanes and nitroarenes, polycyclic aromatic hydrocarbons and other derivates. Lymphocyte-DNA adduct formation is associated with exposure to diesel exhaust particulates and may be associated with an increased risk of developing lung cancer. Diesel Exhaust Particulate is reasonably anticipated to be a human carcinogen. (NCI05)
C44375	Diethyl_Sulfate	Organo-sulfur_Carcinogen	Diethyl Sulfate|DS|Ethyl Sulfate|Sufuric Acid Diethyl Ester	A colorless, corrosive, oily liquid that darkens with age and has a faint peppermint odor. Diethyl sulfate is mainly used as an ethylating agent in organic synthesis and in the dye and textile manufacturing. Exposure to this substance results in severe irritation to the eyes, skin and respiratory tract. It is a possible mutagen and is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals and may be associated with developing laryngeal cancer. (NCI05)
C44376	Diglycidyl_Resorcinol_Ether	Carcinogenic_Epoxide	Diglycidyl Resorcinol Ether|1,3-Bis(2,3-epoxypropoxy)benzene|1,3-Diglycidyloxybenzene|2,2'-[1,3-Phenylenebis(oxymethylene)]bisoxirane|Araldite ERE 1359|NCI-C54966|RDGE|Resorcinol Bis(2,3-epoxypropyl)ether	A combustible, yellowish liquid with a slight phenolic odor. Diglycidyl resorcinol ether is used as a liquid spray epoxy resin and in the production of other epoxy resins. Exposure to this substance irritates the eyes, skin and respiratory tract and adversely affects the immune system, central nervous system, liver and gastrointestinal tract. This substance is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44377	Dimethyl_Sulfate	Organo-sulfur_Carcinogen	Dimethyl Sulfate|Dimethyl Monosulfate|Methyl Sulfate|Sulfuric Acid Dimethyl Ester	An odorless, corrosive, oily liquid with an onion-like odor that emits toxic fumes upon heating. Dimethyl sulfate is used in industry as a methylating agent in the manufacture of many organic chemicals. Inhalation exposure to its vapors is highly irritating to the eyes and lungs and may cause damage to the liver, kidney, heart and central nervous system, while dermal contact causes severe blistering. It is a possible mutagen and is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44378	Dimethylcarbamoyl_Chloride	Organic_Carcinogen	Dimethylcarbamoyl Chloride|Chloroformic Acid Dimethylamide|DMCC|Dimethylcarbamic Chloride|N,N-Dimethylcarbamoyl Chloride	A colorless liquid that is rapidly hydrolyzed in water. Dimethylcarbamoyl chloride is used as a chemical intermediate in the production of pharmaceuticals, pesticides and dyes. Exposure to this substance results in eye irritation, damaged mucous membranes of the nose, throat, and lungs and causes liver disturbance. Dimethylcarbamoyl chloride is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44379	Dimethylvinyl_Chloride	Carcinogenic_Chlorinated_Hydrocarbon	Dimethylvinyl Chloride|1-Chloroisobutylene|2,2-Dimethylvinyl Chloride|2-Methyl-1-chloropropene|2-Methyl-1-propenyl Chloride|Isocrotyl Chloride	A clear, colorless, highly volatile and flammable liquid chlorinated hydrocarbon that emits highly toxic fumes of hydrochloric acid and other chlorinated compounds when heated to decomposition. Dimethylvinyl chloride is exclusively used for research purposes in organic synthesis and in the production of isobutylene compounds.  This substance is reasonably anticipated to be a human carcinogen. (NCI05)
C44380	Disperse_Blue_1	Carcinogenic_Anthraquinone	Disperse Blue 1|1,4,5,8-Tetraamino Anthraquinone|1,4,5,8-Tetraamino-9,10-anthracenedione|Acetate Blue G|Acetoquinone Blue L|Amacel Blue GG|C.I. Disperse Blue 1|CI 64500|Celliton Blue Extra|Celliton Blue G	A blue to black colored aminoanthraquinone dye. Disperse blue 1 is primarily used in hair color formulations and in coloring fabrics and plastics, but has also been used as a fabric dye. Exposure to disperse blue 1 irritates the eye and skin. Disperse blue 1 is a mutagen and is reasonably anticipated to be a human carcinogen. (NCI05)
C44381	Epichlorohydrin	Carcinogenic_Epoxide	Epichlorohydrin|1-Chloro-2,3-epoxypropane|3-Chloro-1,2-propylene Oxide|Chloromethylethylene Oxide|Chloromethyloxirane|EPA|Epichlorhydrin|NCI-CO7001|dl-a-Epichlorohydrin	A volatile and flammable, clear, colorless, liquid, chlorinated cyclic ether with an irritating, chloroform-like odor that emits toxic fumes of hydrochloric acid and other chlorinated compounds when heated to decomposition. Epichlorohydrin is used in the manufacture of epoxy resins, synthetic glycerin and elastomers. Exposure to epichlorohydrin irritates the eyes, skin and respiratory tract, and can cause chemical pneumonitis, pulmonary edema, and renal lesions.  This substance also affects the blood. Epichlorohydrin is reasonably anticipated to be a human carcinogen and may be associated with an increased risk of developing respiratory cancer. (NCI05)
C44382	Erionite	Carcinogenic_Mineral	Erionite|Zeolite	A naturally occurring, fibrous mineral consisting of white, prismatic crystals. Erionite is one of the more common types of zeolites that are found in the earth's crust. This mineral is used as a metal-impregnated catalyst, as a fertilizer, to control odors in livestock production and is used in animal feed, pet litter and horticultural applications. Excessive inhalation of its dust can cause pulmonary fibrosis or silicatosis and prolonged exposure to erionite causes mesothelioma in humans. It is known to be a human carcinogen. (NCI05)
C44383	Ethylene_Dichloride	Carcinogenic_Chlorinated_Hydrocarbon	Ethylene Dichloride|1,2-Dichloroethane|1,2-Ethylene Dichloride|Dichloroethylene|EDC|Ethane Dichloride|Ethylene Chloride|Glycol Dichloride|NCI-C00511|NU-G00511	A clear, colorless, oily, synthetic, flammable liquid chlorinated hydrocarbon with a pleasant chloroform-like smell that emits toxic fumes of hydrochloric acid when heated to decomposition. Ethylene dichloride is primarily used to produce vinyl chloride. Inhalation exposure to this substance induces respiratory distress, nausea and vomiting and affects the central nervous system, liver and kidneys. It is mutagenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05)
C44384	Ethylene_Thiourea	Organic_Carcinogen	Ethylene Thiourea|1,3-Ethylene-2-thiourea|2-Imidazolidine-2-thione|2-Mercaptoimidazoline|4,5-Dihydroimidazol-2(3h)-thione|ETU|N,N-Ethylenethiourea	A greenish, crystalline compound with a faint amine smell and emits toxic fumes of nitrogen oxides and sulfur oxides when heated to decomposition. Ethylene thiourea is mainly used as an accelerator in the production of rubber, and in the manufacture of ethylene bisdithiocarbamate pesticides. This substance is teratogenic in animals and is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44385	Furan	Cyclic_Ether_Carcinogen	Furan|1,4-Epoxy-1,3-butadiene|Furfuran|Oxycyclopentadiene	A clear, colorless, flammable liquid cyclic ether with an ethereal odor. Furan is used as an intermediate in the production of tetrahydrofuran, pyrrole and thiophene. Inhalation exposure to this substance causes eye and skin irritation and central nervous system depression. Furan is mutagenic in animals and is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44386	Gamma_Radiation	Ionizing_Radiation	Gamma Radiation|Gamma Ray	High-energy, short wavelength, ionizing electromagnetic radiation emitted from the nucleus. Gamma radiation frequently accompanies alpha and beta emissions and always accompanies fission. Gamma rays are very penetrating and are best stopped or shielded by dense materials, such as lead or depleted uranium. Gamma rays are identical to x-rays and are only fifferentiated by their origin. (from NRC Glossary)
C44387	Glycidol	Carcinogenic_Epoxide	Glycidol|2,3-Epoxy-1-propanol|2,3-Epoxypropanol|3-Hydroxy-1,2-epoxypropane|Epihydrin Alcohol|Glycide|Glycidyl Alcohol|Oxiranylmethanol|Oxyranyl Methyl Alcohol	Slightly viscous, colorless and odorless liquid cyclic ether. Glycidol is used as a stabilizer for natural oils and vinyl polymers, as an alkylating agent, a sterilant, a demulsifier, a dye-leveling agent and it is also used as an intermediate in the synthesis of glycerol, glycidyl ethers and amines. Exposure to Glycidol irritates the skin, eyes, and mucous membranes and depresses the central nervous system in humans. Glycidol induces mutations in human lymphocytes and is reasonably anticipated to be a human carcinogen. (NCI05)
C44388	Hexachlorobenzene	Carcinogenic_Chlorinated_Hydrocarbon	Hexachlorobenzene|HCB|Pentachlorophenyl Chloride|Perchlorobenzene	A stable, white, crystalline chlorinated hydrocarbon that emits very toxic fumes of carbon monoxide, carbon dioxide, hydrochloric acid and other chlorinated compounds when heated to decomposition. Hexachlorobenzene was used as a fungicide and was also used as a chemical intermediate in the manufacture of dyes, synthesis of organic chemicals, rubber and in wood preservation. Prolonged oral exposure to this substance results in a liver disease with associated skin lesions. Hexachlorobenzene is reasonably anticipated to be a human carcinogen based on association between thyroid, liver and kidney cancer and oral exposure in animals. (NCI05)
C44389	Hexachloroethane	Carcinogenic_Chlorinated_Hydrocarbon	Hexachloroethane|1,1,1,2,2,2-Hexachloroethane|Hexachloroethylene|NCI-C04604|Perchloroethane	A crystalline, colorless, toxic, solid chlorinated hydrocarbon with a camphor-like odor and emits toxic and irritating fumes when heated to decomposition. Hexachloroethane was used as an anthelmintic to treat fascioliasis in cattle and sheep, in refining aluminium alloys, in smoke bombs and pyrotechnic and as a degassing agent and polymer additive. Exposure to this substance irritates the skin and mucous membranes, causes liver damage and acts as a central nervous system depressant. Hexachloroethane is reasonably anticipated to be a human carcinogen. (NCI05)
C44390	Hexamethylphosphoramide	Organic_Carcinogen	Hexamethylphosphoramide|ENT-50882|HMPA|Hexamethylphosphamide|Hexamethylphosphorotriamide|Phosphoryl Hexamethyltriamide	A clear, colorless liquid with an aromatic odor that emits toxic fumes of phosphorous oxides and nitrogen oxides when heated to decomposition. Hexamethylphosphoramide is used as a stabilizer against thermal degradation in polystyrene and is used as a solvent in research laboratories. Exposure to this substance irritates the eyes, skin and respiratory-tract. Hexamethylphosphoramide is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44391	HPV-High_Risk	Human_Papillomavirus	HPV-High Risk|Human Papillomaviruses, High Risk
C44392	Hydrazobenzene	Carcinogenic_Aromatic_Amine	Hydrazobenzene|1,1-Hydrazodibenzene|1,2-Diphenylhydrazine|n,n-Bianiline	A colorless, crystalline compound that emits toxic fumes of nitrogen oxides when heated to decomposition. Hydrazobenzene has been used primarily in the dye manufacturing industry as the precursor of the dye intermediate benzidine and is also used as an intermediate in the manufacture of pharmaceuticals. Exposure to this substance irritates the skin, nose, throat and lungs and can eventually lead to liver, kidney and brain damage. Hydrazobenzene is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in experimental animals. (NCI05)
C44393	Indeno_1_2_3-cd_pyrene	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	Indeno[1,2,3-cd]pyrene|1,10-(1,2-Phenylene)pyrene|1,10-(o-Phenylene)pyrene|IP|ortho-Phenylenepyrene	A yellowish, aromatic hydrocarbon consisting of six fused rings and produced by the incomplete combustion of organic matter. Indene[1,2,3-cd]pyrene is primarily found in certain foods, gasoline and diesel exhaust, cigarette smoke, coal tar and coal tar pitch, soot and petroleum asphalt. This substance is used only for research purposes. Indene[1,2,3-cd]pyrene is reasonably anticipated to be a human carcinogen. (NCI05)
C44394	Iron_Dextran_Complex	Carcinogenic_Mixture	Iron Dextran Complex|Iron Dextran Injection	A complex of ferric hydroxide and dextran that is a sterile, dark brown colloidal solution when used for human injection. Iron dextran complex is primarily used for parental treatment of iron-deficiency anemia when oral administration of iron has failed. This complex is reasonably anticipated to be a human carcinogen based on formation of local sarcomas at the site of injection in experimental animals. (NCI05)
C44395	Lead_Compound	Carcinogenic_Metal	Lead Compound	An inorganic or organic substance that contains the metallic element lead either in its positive-2 or 4 valence state. Lead compounds have a wide variety of applications in industry. Exposure to lead compounds affects the lungs, central nervous system and kidneys. Lead compounds are possible mutagens and are reasonably anticipated to be human carcinogens. The substance may be associated with an increased risk of developing lung and stomach cancer. (NCI05)
C44396	Lead_Metal	Carcinogenic_Metal|Metals	Lead Metal|Metallic Lead|Pb	An element with atomic symbol Pb, atomic number 82, and atomic weight 207.2.
C44397	Lindane	Chlorinated_Ring_Carcinogen	Lindane|(1alpha,2alpha,3beta,4alpha,5alpha,6beta)1,2,3,4,5,6-Hexachlorocyclohexane|LINDANE|g-Benzene Hexachloride|gamma-HCH|gamma-Hexachlorocyclohexane	A colorless to white colored, synthetic, crystalline solid chlorinated hydrocarbon with a slight musty odor that emits toxic fumes of hydrochloric acid and other chlorinated compounds when heated to decomposition. Lindane is used as an insecticide for hardwood logs, lumber, and crops.  It is also used topically against lice and scabies. Inhalation exposure to this substance causes severe irritation of the nose, throat, causes anemia and affects the liver, nervous, cardiovascular and immune system. Lindane is reasonably anticipated to be a human carcinogen. (NCI05)
C44398	Methoxsalen_With_Ultraviolet_A_Therapy	Phototherapy	Methoxsalen With Ultraviolet A Therapy|8-Methoxypsoralen Plus Ultraviolet Radiation|PUVA|Ultraviolet Light Therapy Using Methoxsalen	Strong evidences have indicated causal association between 8-methoxypsoralen with UVA (PUVA) treatment and non-melanocytic skin patients with psoriasis.  8-Methoxypsoralen alone did not alter the incidence of new skin cancer development in a 2-year study.  In a large number of studies, 8-Methoxypsoralen in combination with ultraviolet A radiation induced chromosomal aberrations, sister chromatid exchanges, mutation, DNA damage and DNA cross-links in human cells in vitro.  This treatment is classified as carcinogenic to Human by IARC. (NCI05)
C44399	Methyl_Methanesulfonate	Organo-sulfur_Carcinogen	Methyl Methanesulfonate|MMS|Methanesulfonic Acid Methyl Ester|Methyl Mesylate|NSC-50256|as-Dimethyl Sulfite	A stable, colorless, combustible liquid that emits toxic fumes of sulfoxide when heated to decomposition. Methyl methanesulfonate is used for laboratory purposes as a catalyst in chemical synthesis and has been tested clinically as a cancer chemotherapeutic agent. This substance is an alkylating agent and acts as a mutagen by altering and damaging DNA and is reasonably anticipated to be a human carcinogen. (NCI05)
C44400	Methylene_Chloride	Carcinogenic_Chlorinated_Hydrocarbon	Methylene Chloride|DCM|Dichloromethane|Methane Dichloride|Methylene Dichloride|NCI-C50102	A clear, colorless, nonflammable, volatile liquid chlorinated hydrocarbon with a sweet, pleasant smell and emits highly toxic fumes of phosgene when heated to decomposition. Methylene chloride is primarily used as a solvent in paint removers, but is also used in aerosol formulations, as a solvent in the manufacture of pharmaceuticals, as a degreasing agent, in electronics manufacturing and as an ethane foam blowing agent. Inhalation exposure to this substance irritates the nose and throat and affects the central nervous system. Methylene chloride is a possible mutagen and is reasonably anticipated to be a human carcinogen. (NCI05)
C44401	Methyleugenol	Organic_Carcinogen	Methyleugenol|1,2-Dimethoxy-4-allylbenzene|1,3,4-Eugenol Methyl Ether|1-(3,4-Dimethoxyphenyl)-2-propene|1-Allyl-3,4-dimethoxybenzene|4-Allyl-1,2-dimethoxybenzene|4-Allylveratrole|Veratrole Methyl Ether	A yellowish, oily, naturally occurring liquid with a clove-like aroma and is present in many essential oils. Methyleugenol is used as a flavoring agent, as a fragrance and as an anesthetic in rodents. Methyleugenol is mutagenic in animals and is reasonably anticipated to be a human carcinogen based on evidence of carcinogenicity in animals. (NCI05)
C44402	Michlers_Base	Carcinogenic_Aromatic_Amine	Michler's Base|4,4'-Bis(dimethylamino)diphenylmethane|4,4'-Methylenebis(N,N-dimethyl)benzenamine|4,4'-Methylenebis(N,N-dimethylaniline)|4,4'-Methylenebis(N,N-dimethylbenzenamine)|4,4'-Tetramethyldiaminodiphenylmethane|Arnold's Base|Methane Base|Michler's Hydride|Michler's Methane|Tetra-base|Tetrabase	A yellow colored, combustible leaflet material that emits toxic fumes of nitrogen oxides when heated to decomposition. Michler's base is used as a chemical intermediate in the manufacture of dyes and for its hydrochloric salt and is also used as an analytical reagent in the determination of lead. Exposure to Michler's base irritates the skin and eyes and can lead to methemoglobinemia and respiratory tract distress. Michler's base is reasonably anticipated to be a human carcinogen. (NCI05)
C44403	Michlers_Ketone	Organic_Carcinogen	Michler's Ketone|4,4'-(Dimethylamino)benzophenone|Bis(4-(dimethylamino)phenyl)methanone|Bis(p-(N,N-dimethylamino)phenyl)ketone|NCI-C02006|Tetramethyldiaminobenzophenone|p,p'-Bis(N,N-dimethylamino)benzophenone|p,p'-Michler's Ketone	A white to green colored leaflet material that emits toxic fumes of nitrogen oxides when heated to decomposition. Michler's ketone is used as a chemical intermediate in making dyes and pigments, particularly auramine derivatives, for dyeing paper, textiles, and leather. Exposure to Michler's ketone affects the central nervous system. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44404	Mirex	Chlorinated_Ring_Carcinogen	Mirex|1,1a,2,2,3,3a,4,5,5,5a,5b,6-Dodecachloro-octahydro-1,3,4-metheno-1H-cyclbuta[cd]pentalene|CG-1283|Dechlorane|ENT-025719|Hexachloropentadiene Dimer|Perchloropentacyclodecane	A white, stable, odorless, synthetic, crystalline solid chlorinated hydrocarbon. Mirex was used as an insecticide against ants and as a fire-retardant for plastics, paint, rubber, paper and electrical appliances, but it is no longer produced or used in the US. Exposure to Mirex irritates the skin and eyes and causes a headache as well as dizziness, nausea and vomiting and affects the central nervous system, lungs, liver and kidneys. Mirex is reasonably anticipated to be a human carcinogen. (NCI05)
C44405	Monofluoroethene	Carcinogenic_Fluorinated_Hydrocarbon	Monofluoroethene|1-Fluoroethene|1-Fluoroethylene|Monofluoroethylene|Vinyl Fluoride	A synthetic, colorless gas that is insoluble in water and soluble in organic solvents. It is used primarily in the production of polyvinyl fluoride and other fluoropolymers. Vinyl fluoride is extremely flammable and emits highly toxic hydrogen fluoride gas when burned. Vinyl fluoride metabolites form covalent DNA adducts that attribute to inhibition of DNA replication and to mutagenicity consequences. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44406	Mustard_Gas	Organo-sulfur_Carcinogen	Mustard Gas|1,1'-Thiobis(2-chloroethane)|2,2'-Dichlorodiethyl Sulfide|Dichlorodiethyl Sulfide|Sulfur Mustard Gas|bis(2-Chloroethyl) Sulfide	A pale yellow, oily, highly toxic, volatile, liquid alkylating compound with a sweet to garlic-like odor that evaporates to a poisonous gas. Mustard gas is a vesicant that was first used in chemical warfare in World War I, but is now only used in small amounts in research studies involving alkylating agents. Exposure to this substance is corrosive to the eyes, skin and lungs and leads to blindness and blistering of the skin and can cause severe and sometimes fatal respiratory damage. Mustard gas is a mutagen and is a known carcinogen that is associated with an increased risk of developing lung and other respiratory tract cancers. (NCI05)
C44407	Nickel_Compound	Carcinogenic_Metal	Nickel Compound	A strong, corrosion and heat resistant, inorganic substance that contains the metallic element nickel. Nickel compounds are used in industry for electroplating, nickel-alloy production, stainless steel production, in batteries, in electronics, in the ceramic industry and as catalysts. Exposure to nickel compounds affects the kidneys and respiratory tract and is associated with developing lung and nasal cancer. (NCI05)
C44408	Nitrilotriacetic_Acid	Organo-nitrogen_Carcinogen	Nitrilotriacetic Acid|N,N-bis(carboxymethoxy)glycine|NTA|Tri(carboxymethyl)amine|Triglycine|Triglycollamic Acid	A white, crystalline solid compound. Nitrilotriacetic acid is mainly used as a chelating and eluting agent and is found in laundry detergents. Exposure to Nitrilotriacetic acid irritates the skin, eyes and respiratory tract and causes kidney and bladder damage. Nitrilotriacetic acid is reasonably anticipated to be a human carcinogen. (NCI05)
C44409	Nitroarene_Compound	Organic_Chemical	Nitroarene Compound|Nitroarenes
C44410	Nitrobenzene	Nitro-compound_Carcinogen	Nitrobenzene|Mirbane Oil|Nitrobenzol	A yellowish, oily, aromatic nitro-compound with an almond-like odor that emits toxic fumes of nitrogen oxides upon combustion. Nitrobenzene is primarily used in the manufacture of aniline, but is also used in the manufacture of lubricating oils, dyes, drugs, pesticides, and synthetic rubber. Exposure to nitrobenzene irritates the skin, eyes and respiratory tract and can result in methemoglobinemia causing fatigue, dyspnea, dizziness, disturbed vision, shortness of breath, collapse and even death. Nitrobenzene also damages the liver, spleen, kidneys and central nervous system. This substance is a possible mutagen and is reasonably anticipated to be a human carcinogen. (NCI05)
C44411	Nitrofen	Nitro-compound_Carcinogen	Nitrofen|2,4-Dichloro-1-(4-nitrophenoxy)benzene|2,4-Dichloro-4'-nitrodiphenyl Ether|2,4-Dichlorophenyl p-Nitrophenyl Ether|FW-925|Nitraphen	A white, crystalline, solid, combustible, chlorinated compound. Nitrofen was used as an herbicide, but is no longer used or manufactured in the United States. Exposure to nitrofen irritates the skin, eyes and respiratory tract and affects the blood and central nervous system. This substance is teratogenic and carcinogenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05)
C44412	Nitromethane	Nitro-compound_Carcinogen	Nitromethane|Nitrocarbol	A colorless, oily, highly flammable liquid with a strong, disagreeable odor that emits toxic fumes of nitrogen oxides upon decomposition. Nitromethane is used to make industrial antimicrobials and pharmaceuticals, and is also used as a soil fumigant and as a fuel in race car engines. Exposure to nitromethane irritates the skin and affects the central nervous system causing nausea, dizziness and narcosis. This substance is reasonably anticipated to be a human carcinogen. (NCI05)
C44413	Nitrosodipropylamine	Carcinogenic_Nitrosamine	Nitrosodipropylamine|DPNA|Di-n-propylnitrosamine|N-Nitroso-N-propyl-1-propanamine|N-Nitrosodi-n-propylamine|NDPA	A yellow, liquid nitrosamine that rapidly degrades in the presence of light and emits toxic fumes of nitrogen oxides when heated to decomposition. Nitrosodipropylamine is found as a contaminant in cheese, alcoholic beverages, rubber products and certain herbicides. Nitrosodipropylamine may be formed in vivo by the nitrosation of propylamine in the presence of nitrite. This substance is solely used for research purposes to induce tumors in experimental animals. Nitrosodipropylamine is reasonably anticipated to be a human carcinogen. (NCI05)
C44414	Nitrosonornicotine	Carcinogenic_Cyclic_Nitrosamine	Nitrosonornicotine|1'-Demethyl-1'-nitroso-nicotine|1'-Nitrosonornicotine|3-(1-Nitroso-2-pyrrolidinyl)pyridine|N-nitrosonornicotine|NNN|anti-N'-nitrosonornicotine|syn-N'-nitrosonornicotine	A yellow, oily liquid nitrosamine that solidifies at cold temperatures and emits toxic fumes of nitrogen oxides when heated to decomposition. Nitrosonornicotine is found in tobacco products and is likely produced by the nitrosation of nicotine during the making and smoking of tobacco products. This substance is only used in research to induce tumors in experimental animals. Exposure to nitrosonornicotine affects the liver and nitrosonornicotine is reasonably anticipated to be a human carcinogen. (NCI05)
C44415	N-Methyl-N-nitro-N-Nitrosoguanidine	Carcinogenic_Nitrosamine	N-Methyl-N-nitro-N-Nitrosoguanidine|1-Methyl-3-nitro-1-nitrosoguanidine|MNG|MNNG|N'-nitro-N-nitroso-N-methylguanidine|NCI-C01423|NG|NSC-9369	A pale yellow to pink colored, crystalline solid nitrosamine that turns green or orange when exposed to light and emits very toxic fumes of nitrogen oxides when heated to decomposition. N-methyl-N-nitro-N-nitrosoguanidine is used in laboratory research as an experimental mutagen, teratogen and carcinogen. Exposure to this substance irritates the eyes, skin and respiratory-tract. N-methyl-N-nitro-N-nitrosoguanidine is reasonably anticipated to be a human carcinogen. (NCI05)
C44416	N-Nitrosodiethanolamine	Carcinogenic_Nitrosamine	N-Nitrosodiethanolamine|2,2'-(Nitrosoimino)bisethanol|N-nitrosobis(2-hydroxyethyl)amine|N-nitrosoiminodiethanol	A pale yellow, oily liquid nitrosamine with a characteristic odor that is light sensitive and emits toxic fumes of nitrogen oxides when heated to decomposition. N-Nitrosodi-n-butylamine is primarily used in laboratory research to induce tumors in experimental animals, but is also used as an intermediate in the synthesis of di-n-butylhydrazine. This substance is detected in various foods, including smoked meats, cheese and soybean oil, as a result of nitrosation of amines that are present in these products and is detected as a contaminant in rubber products. Exposure to N-Nitrosodi-n-butylamine irritates the skin and eyes and may damage the liver and kidneys. This substance is mutagenic in animals and is reasonably anticipated to be a human carcinogen. (NCI05)
C44417	N-Nitrosodimethylamine	Carcinogenic_Nitrosamine	N-Nitrosodimethylamine|DMN|DMNA|Dimethylnitrosamine|N-Methyl-N-nitrosomethanamine|NDMA	A volatile, combustible, yellow, oily liquid nitrosamine with a faint characteristic odor that decomposes when exposed to light and emits toxic fumes of nitrogen oxides when heated to decomposition. N-Nitrosodimethylamine is primarily used in laboratory research to induce tumors in experimental animals. This substance may be formed during the cooking of foods, especially cured meats and fish, that contain sodium nitrite as a preservative, but is also found in several vegetables, cheeses, alcoholic beverages and fruits, and as a contaminant in rubber products. Exposure to NNitrosodimethylamine irritates the skin and eyes and damages the liver. This substance is reasonably anticipated to be a human carcinogen. (NCI05)
C44418	N-Nitrosodi-n-butylamine	Carcinogenic_Nitrosamine	N-Nitrosodi-n-butylamine|N-butyl-N-nitroso-1-butanamine|NDBA	A yellow, viscous, oily nitrosamine that is highly unstable in the presence of light. N-Nitrosodiethanolamine is ubiquitously found in the environment and is a contaminant formed by the reaction of nitrites with ethanolamines in a wide range of products including tobacco, pesticides, antifreeze and personal care products. This substance is only used for research purposes to induce tumors in experimental animals. N-Nitrosodiethanolamine is reasonably anticipated to be a human carcinogen. (NCI05)
C44419	N-Nitrosomethylvinylamine	Carcinogenic_Nitrosamine	N-Nitrosomethylvinylamine|N-Methyl-N-nitroso-ethenylamine|N-Methyl-N-nitrosovinylamine|NMVA	A yellow, volatile liquid nitrosamine that emits toxic fumes of nitrogen oxides when heated to decomposition.  N-Nitrosomethylvinylamine has been found in several vegetables, cheeses, meats, alcoholic beverages and fruits. It is only used as a research chemical to induce tumor formation. Exposure to this substance causes liver and kidney damage. N-Nitrosomethylvinylamine is reasonably anticipated to be a human carcinogen. (NCI05)
C44420	N-Nitrosomorpholine	Carcinogenic_Cyclic_Nitrosamine	N-Nitrosomorpholine|4-Nitrosomorpholine|NMOR	A yellow, crystalline nitrosamine that is sensitive to light. N-Nitrosomorpholine is not used or produced commercially in the US. This substance has been found as a contaminant in rubber products, including rubber nipples for baby bottles, and is also found in several vegetables, cheeses, alcoholic beverages and fruits. N-Nitrosomorpholine is reasonably anticipated to be a human carcinogen. (NCI05)
C44421	N-Nitroso-N-Ethylurea	Retired_Concepts	N-Nitroso-N-Ethylurea|1-Ethyl-1-nitrosourea|ENU
C44422	N-Nitroso-N-Methylurea	Retired_Concepts	N-Nitroso-N-Methylurea|1-Methyl-1-nitrosourea|MNU|N-nitroso-N-methylcarbamide|NMH|NMU
C44423	N-Nitrosopiperidine	Carcinogenic_Cyclic_Nitrosamine	N-Nitrosopiperidine|1-Nitrosopiperidine|Hexahydro-N-nitroso-pyridine|N-N-PIP|NO-PIP|NPIP	A clear, yellow, oily, liquid that is light sensitive and emits toxic fumes of nitrogen oxides when heated to decomposition. N-Nitrosopiperidine is used in laboratory research to induce tumors in experimental animals. This substance is naturally formed in foods that contain sodium nitrite as a preservative, including meat, fish and cheese, as a result of nitrosation of piperidine in the presence of nitrite. N-Nitrosopiperidine is reasonably anticipated to be a human carcinogen. (NCI05)
C44424	N-Nitrosopyrrolidine	Carcinogenic_Cyclic_Nitrosamine	N-Nitrosopyrrolidine|1-Nitrosopyrrolidine|Tetrahydro-N-nitroso-pyrrole	A clear, yellow, oily, liquid nitrosamine that decomposes when exposed to light and emits toxic fumes of nitrogen oxides when heated to decomposition. N-Nitrosopyrrolidine is used in laboratory research to induce tumors in experimental animals. This substance may be formed during cooking of foods that contain sodium nitrite as a preservative, including meat, fish and cheese. Exposure to N- Nitrosopyrrolidine irritates the skin and eyes and can damage the liver and kidneys. This substance is reasonably anticipated to be a human carcinogen. (NCI05)
C44425	N-Nitrososarcosine	Carcinogenic_Nitrosamine	N-Nitrososarcosine|N-Methyl-N-Nitroso-Glycine|N-Nitrosomethylglycine|NSAR	A pale yellow, crystalline solid nitrosamine that decomposes when exposed to light and emits toxic fumes of nitrogen oxides when heated to decomposition. N-Nitrososarcosine is used in laboratory research to induce tumors in experimental animals. This substance may be formed during the cooking of foods that contain sodium nitrite as a preservative, including meat, fish and cheese. Exposure to N-Nitrososarcosine irritates the skin and eyes. This substance is reasonably anticipated to be a human carcinogen. (NCI05)
C44426	o-Anisidine_Hydrochloride	Carcinogenic_Aromatic_Amine	o-Anisidine Hydrochloride|1-Amino-2-Methylbenzene Hydrochloride|2-Aminoanisole Hydrochloride|2-Methoxyaniline Hydrochloride|2-Methoxybenzenamine Hydrochloride|C.I. 37115|Fast Red BB Base	A pink to yellow colored, liquid, aromatic amine with an amine-like odor that emits toxic fumes of nitrogen oxide when heated to decomposition. o-Anisidine hydrochloride is used in industry as a chemical intermediate in the production of dyes and pharmaceuticals. Exposure to this substance irritates the skin and can cause headaches, vertigo, and affects the blood. o-Anisidine hydrochloride is reasonably anticipated to be a human carcinogen. (NCI05)
C44427	Ochratoxin_A	Organic_Carcinogen	Ochratoxin A|(R)-N-[(5-chloro-3,4-dihydro-8-hydroxy-3-methyl-1-oxo-1H-2-benzopyran-7-yl)carbonyl]-L-phenylalanine|OTA	A white, crystalline powder that is very unstable in the presence of light but fairly heat resistant. Ochratoxin A is a widespread, naturally occurring mycotoxin that is produced by some fungi, especially by Aspergillus and Penicillium, and is a very common food contaminant found on grains, coffee beans, nuts, decaying vegetation, moldy cereals and animal feeds. This toxin is used in research as an experimental teratogen and carcinogen. Ochratoxin A is reasonably anticipated to be a human carcinogen and may be associated with an increased risk of developing urinary tract tumors. (NCI05)
C44428	o-Tolidine	Carcinogenic_Aromatic_Amine	o-Tolidine|3,3'-Dimethyl-4,4'-biphenyldiamine|3,3'-Dimethylbenzidine|3,3'-Dimethyldiphenyl-4,4'-diamine|3,3'-Tolidine|3,3-Dimethylbenzidine|4,4'-Bi-o-toluidine|4,4'-Diamino-3,3'-dimethylbiphenyl|C.I. Azoic Diazo Component 113|Diaminoditolyl|Fast dark blue base R	A white to reddish colored, combustible, aromatic amine that emits toxic fumes of nitrogen oxides when heated to decomposition. o-Tolidine is used in industry as a dye or as an intermediate in the manufacture of dyes and pigments and is also used in clinical laboratories for the detection of blood. Exposure to this substance irritates the eyes, skin and respiratory tract and damages the kidneys and liver. o-Tolidine is reasonably anticipated to be a human carcinogen. (NCI05)
C44429	o-Toluidine	Carcinogenic_Aromatic_Amine	o-Toluidine|2-Aminotoluene|2-Methylaniline|2-Methylbenzenamine|CI 37077|o-Toluidine Hydrochloride|ortho-Toluidine	A synthetic, light sensitive, light yellow liquid that is slightly soluble in water and miscible with carbon tetrachloride, diethyl ether and ethanol. The hydrochloride is a synthetic, light sensitive, white crystalline powder that is soluble in dimethylsulfoxide and ethanol. o-Toluidine and o-toluidine hydrochloride are used primarily as intermediates in the manufacture of dyes and pigments. When heated to decomposition, o-toluidine emits toxic fumes of nitrogen oxides while the hydrochloride also produces hydrochloric acid. Four studies of workers exposed to o-toluidine reported an excess of bladder cancers. o-Toluidine and o-toluidine hydrochloride are reasonably anticipated to be human carcinogens. (NCI05)
C44430	p-Biphenylamine	Carcinogenic_Aromatic_Amine	p-Biphenylamine|1,1'-Biphenyl-4-amine|4-Aminobiphenyl|Anilinobenzene|p-Aminodiphenyl	A colorless, crystalline, solid aromatic amine that turns purple when exposed to air and emits toxic fumes when heated. p-Biphenylamine is used only in laboratory research to induce tumorigenesis. Exposure to p-biphenylamine causes headaches, lethargy, cyanosis, urinary burning and hematuria. p-Biphenylamine is a mutagen and carcinogen in humans and is associated with an increased risk of developing bladder cancer. (NCI05)
C44431	p-Chloro-o-toluidine	Carcinogenic_Aromatic_Amine	p-Chloro-o-toluidine|2-Amino-5-chlorotoluene|2-Methyl-4-chloroaniline|3-Chloro-6-aminotoluene|4-Chloro-2-methylaniline|p-Chloro-o-toluidine Hydrochloride	A yellowish to pinkish colored, synthetic leaflet material. p-Chloro-o-toluidine is used in industry in the manufacture of azo dyes and is used in the production of the pesticide chlordimeform. This substance is a possible mutagen and is reasonably anticipated to be a human carcinogen that may be associated with an increased risk of bladder cancer. (NCI05)
C44432	Phenacetin	Organo-nitrogen_Carcinogen	Phenacetin|1-Acetamido-4-ethoxybenzene|4-Ethoxy Acetanilide|Acetophenetin|N-(4-ethoxyphenol)acetamide|p-Acetophenetidide|para Acetylphenetidin	A synthetic, white crystalline solid that is slightly soluble in water and benzene, soluble in acetone and very soluble in pyrimidine. It is used in research as the preferred marker for detecting CYP1A2-based inhibition potential in vitro. Human ingestion of phenacetin can result in a bluish discoloration of the skin due to a lack of oxygen in the blood (cyanosis), dizziness and respiratory depression. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44433	Phenacetin-Containing_Mixture	Organo-nitrogen_Carcinogen	Phenacetin-Containing Mixture|Analgesic Mixtures Containing Phenacetin	Analgesic mixtures containing phenacetin are no longer available in the United States. These are known to be human carcinogens. (NCI05)
C44434	Phenazopyridine_Hydrochloride	Carcinogenic_Aromatic_Amine	Phenazopyridine Hydrochloride|2,6-Diamino-3-(phenylazo)-pyridine Hydrochloride|3-(Phenylazo)-2,6-pyridinediamine Monohydrochloride	A synthetic, brick-red crystalline solid that is only slightly soluble in cold water and ethanol but is soluble in boiling water, acetic acid, glycerol, ethylene glycol and propylene glycol. It is used orally as a urinary tract analgesic. Side effects of phenazopyridine hydrochloride administration can include nausea, interference with the oxygen-carrying capacity of red blood cells (methemoglobinemia), hemolytic anemia as well as renal and hepatic toxicity. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44435	Phenoxybenzamine	Carcinogenic_Aromatic_Amine	Phenoxybenzamine Hydrochloride|N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine|N-(2-chloroethyl)-N-(1-methyl-2-phenoxyethyl)-benzenemethanamine Hydrochloride|PHENOXYBENZAMINE HYDROCHLORIDE|Phenoxybenzamine	A synthetic, light-sensitive, colorless crystalline solid that is only sparingly soluble in water but is soluble in ethanol, chloroform and propylene glycol. It is used primarily to treat hypertension and, under certain conditions, to treat enlargement of the prostate gland. Phenoxybenzamine is also the preferred alpha-blocker in preparation for surgery. Side effects of phenoxybenzamine hydrochloride administration may include sedation, fatigue, nasal congestion, contraction of the pupil of the eye (miosis), postural hypotension with dizziness and compensatory tachycardia. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44436	Polybrominated_Biphenyl	Carcinogenic_Brominated_Hydrocarbon	Polybrominated Biphenyl|Brominated Biphenyls|Hexabromobiphenyls|PBBs|Polybromobiphenyls	A mixture of synthetic solids, containing three or more bromine atoms, that is virtually insoluble in water but is soluble in fat and various organic solvents. There are 209 different molecular combinations, or congeners, that are possible for polybrominated biphenyls. These mixtures are no longer used or produced in commercial quantities in the United States. Residues remaining in and around plants that formerly manufactured, processed or produced products using polybrominated biphenyls are the current sources for human exposure. The primary routes of potential human exposure to polybrominated biphenyls are ingestion, inhalation, and dermal contact. A commercial mixture of these compounds is reasonably anticipated to be a human carcinogen. (NCI05)
C44437	Propanesultone	Organo-sulfur_Carcinogen	Propanesultone|1,2-Oxathiolane 2,2-Dioxide|1,3-Propane Sultone|3-Hydroxy-1-propanesulfonic Acid gamma-Sultone|gamma-Propane Sultone	A synthetic, colorless liquid or white crystalline solid that is readily soluble in water and many organic solvents such as ketones, esters and aromatic hydrocarbons. 1,3-propanesultone is used as a chemical intermediate in the production of detergents, dyes, lathering agents, bacteriostats, fungicides, insecticides, cation-exchange resins, corrosion inhibitors and vulcanization accelerators. When heated to decomposition, it emits toxic fumes of sulfur oxides. Humans are potentially exposed to residues of 1,3-propane sultone when using products manufactured from this compound. The primary routes of potential human exposure to 1,3-propane sultone are ingestion and inhalation. Contact with this chemical can cause mild irritation of the eyes and skin. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44438	Propylene_Oxide	Carcinogenic_Epoxide	Propylene Oxide|1,2-Epoxypropane|1,2-Propylene Oxide|Methyl Oxirane|Methylethylene Oxide|Propene Oxide	A synthetic, highly-flammable, volatile, colorless liquid that is soluble in water and miscible with many organic solvents. Propylene oxide is used primarily as a chemical intermediate in the production of polyethers and propylene glycol. It is also used as a pesticide and a fumigant for the sterilization of packaged foods and plastic medical instruments. Acute inhalation exposure to vapors of this compound can result in respiratory tract irritation, coughing, difficulty in breathing (dyspnea) and buildup of fluid in the lungs (pulmonary edema) that can possibly lead to pneumonia. Inhale high concentrations of the vapors for short time periods may cause headache, motor weakness, incoordination, ataxia and coma. Contact with propylene oxide can irritate the eyes and skin. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44439	Propylenimine	Organo-nitrogen_Carcinogen	Propylenimine|1,2-Propyleneimine|2-Methylazacyclopropane|2-Methylaziridine|2-Methylethyleneimine	A synthetic, flammable, volatile, colorless oily liquid that is soluble in water, ethanol and most organic solvents. Propylenimine is used in the United States exclusively as an intermediate, and its derivatives are used in the paper, textile, rubber and pharmaceutical industries. Due to its volatility, potential exposure could occur during production, packaging, or use of substances made with this liquid. The primary routes of potential human exposure to propylenimine are inhalation, ingestion and dermal contact. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44440	Respirable_Ceramic_Fiber	Inorganic_Carcinogen	Respirable Ceramic Fiber|Mineral Wool|Respirable Size Ceramic Fiber	Most ceramic fibers are white to cream colored and are typically composed of alumina, silica and other metal oxides. Ceramic fibers are able to withstand high temperatures and are used as insulation material, primarily for lining furnaces and kilns. These fibers are the primary replacement for asbestos. Exposure to ceramic fiber irritates the skin and upper-respiratory tract. Respirable ceramic fiber is reasonably anticipated to be a human carcinogen. (NCI05)
C44441	Respirable_Crystalline_Silica	Silica	Respirable Crystalline Silica|Quartz|Silica Anhydride|Silicon Dioxide|Tripoli	A widespread, naturally occurring, crystalline metal oxide that consists of different forms including quartz, cristobalite, tridymite, tripoli, ganister, chert and novaculite. Respirable crystalline silica is found in industry in metal and nonmetal mining and milling operations as well as in foundries, ceramic industries and at construction sites. Inhalation exposure to respirable crystalline silica causes chronic silicosis, emphysema, lymph node fibrosis and is associated with an increased risk of developing lung cancer. (NCI05)
C44442	Respirable_Glass_Wool	Inorganic_Carcinogen	Respirable Glass Wool|Fiberglass|Fibrous Glass|Glass Fiber	A manufactured fiber in which the fiber-forming substance is glass. Silicon dioxide is the primary chemical component in all glass types; however, many other metal oxides are present. Respirable glass wool has a mass median aerodynamic diameter of approximately 3.5 ?m or less. Fibers less than 1 ?m in diameter have the highest probability for deposition in the alveolar regions of the lung, where gas exchange occurs. The major uses of glass wool are in thermal, electrical, and acoustical insulation, weatherproofing and filtration media. The highest levels of occupational exposure to  this fiber occur when it is used in confined spaces. The primary routes of potential human exposure to glass wool are inhalation and dermal and/or eye contact. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44443	Safrole	Cyclic_Ether_Carcinogen	Safrole|1-Allyl-3,4-methylenedioxybenzene|5-(2-Propenyl)-1,3-benzodioxole|Allylcatechol Methylene Ether	A naturally-occurring, colorless to slightly yellow liquid that is soluble in ethanol, ether, and chloroform. Safrole is no longer used in the United States. Minimal exposure to safrole may occur through the use of edible spices, including nutmeg and mace, which contain low levels of this compound. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44444	Selenium_Sulfide	Topical_Anti-Infective_Agent	Selenium Sulfide|SELENIUM SULFIDE	An orange-yellow powder that is soluble in carbon disulfide and practically insoluble in both water and organic solvents. Selenium sulfide is used as an ingredient in antidandruff shampoos and as a constituent of fungicides. When heated to decomposition, it emits toxic fumes of sulfur oxides and selenium. The primary routes of potential human exposure to selenium sulfide are dermal contact and inhalation. Contact with selenium sulfide can cause severe redness or irritation of the skin. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44445	Solar_Radiation	Nonionizing_Radiation	Solar Radiation
C44446	Soot	Carcinogenic_Mixture	Soot	Black particulate matter formed as by-products of combustion or pyrolysis of organic (carbon-containing) materials, such as coal, wood, fuel oil, waste oil, paper, plastics and household refuse. Their chemical compositions and physical properties are highly variable and depend on the type of starting material and the combustion conditions. Chemically, soots vary with respect to their relative amounts of carbon and the types of organic and inorganic compounds adsorbed to the particles. Physically, soots vary with respect to their particle types, sizes, and shapes. The primary routes of potential human exposure to soots are inhalation, ingestion and dermal contact. The general population may be exposed to soots from fireplaces, furnaces, engine exhaust and particulate emissions from any combustion source. These are known to be human carcinogens. (NCI05)
C44447	Styrene_Oxide	Carcinogenic_Epoxide	Styrene Oxide|1,2-Epoxyethylbenzene|1-Phenyl-1,2-epoxyethane|1-Phenyloxirane|Epoxystyrene|Phenylethylene Oxide|Styrene-7,8-oxide	A synthetic, colorless liquid that is very soluble in water. Styrene oxide is used as a chemical intermediate in the production of styrene glycol and its derivatives, cosmetics, surface coatings and other chemicals (agricultural and biological). It is also used as a reactive diluent for epoxy resins and in cross-linked polyesters and polyurethanes. Humans in the general population may be exposed to styrene oxide by contact with contaminated air or water. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44448	Sulfallate	Organic_Carcinogen	Sulfallate|2-Chlorallyl Diethyldithiocarbamate|2-Chloro-2-propene-1-thiol Diethyldithiocarbamate|2-Chloro-2-propenyl Diethylcarbamodithioate|2-Chloroallyl N,N-diethyldithiocarbamate|CDEC|CP 4572|Carbamic Acid, Diethyldithio-, 2-Chloroallyl Ester|Carbamodithioic Acid, Diethyl-, 2-Chloro-2-propenyl Ester|NCI CO0453|Thioallate|Vegadex	A synthetic, amber oil that is slightly soluble in water and soluble in most organic solvents. Sulfallate products are no longer used in the United States. Therefore, the potential for human exposure is low. When heated to decomposition, sulfallate emits toxic fumes of hydrochloric acid, nitrogen, and sulfur oxides. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44449	Sulfuric_Acid-Containing_Mist	Inorganic_Carcinogen	Sulfuric Acid-Containing Mist|Strong Inorganic Acid Mists Containing Sulfuric Acid	A mist is defined as a liquid aerosol formed by condensation of a vapor or by atomization of a liquid. Sulfuric acid-containing mist may be generated during a process when factors such as evaporation, solution strength, temperature, and pressure combine to effect release of a mist. Sulfuric-acid containing mist may be generated during the production or use of sulfuric acid, sulfur trioxide, or oleum. Acute inhalation exposure to this aerosol can result in respiratory tract irritation. Ingestion of this mist can burn the mouth, throat and stomach; it may ultimately result in death. Contact with sulfuric acid containing mist can both irritate and burn the eyes and skin. It is known to be a human carcinogen. (NCI05)
C44450	Sunlamp_Exposure	Environmental_and_Occupational_Exposure	Sunlamp Exposure|Sunbed Exposure	Using an artificial light source, either sunlamp or sunbed, to generate a tanned skin.
C44451	Tetrachloroethylene	Carcinogenic_Chlorinated_Hydrocarbon	Tetrachloroethylene|1,1,2,2-Tetrachloroethylene|AI3-01860|Carbon Bichloride|Ethylene Tetrachloride|Perchloroethylene|Tetrachloroethene	A colorless, volatile, nonflammable, liquid, chlorinated hydrocarbon with an ether-like odor that may emit toxic fumes of phosgene when exposed to sunlight or flames. Tetrachloroethylene is mainly used as a cleaning solvent in dry cleaning and textile processing and in the manufacture of fluorocarbons. Exposure to this substance irritates the upper respiratory tract and eyes and causes neurological effects as well as kidney and liver damage. Tetrachloroethylene is reasonably anticipated to be a human carcinogen and may be linked to an increased risk of developing skin, colon, lung, esophageal, and urogenital tract cancer as well as lymphosarcoma and leukemia. (NCI05)
C44452	Tetrafluoroethylene	Carcinogenic_Fluorinated_Hydrocarbon	Tetrafluoroethylene|1,1,2,2-Tetrafluoroethylene|Fluoroplast 4|Perfluoroethylene|TFE|Tetrafluoroethene	A synthetic, colorless, flammable gas that is insoluble in water. Tetrafluoroethylene is used primarily in the synthesis of polytetrafluoroethylene resins. It is also used as a monomer in the synthesis of copolymers and as a propellant for food product aerosols. When heated to decomposition, tetrafluoroethylene emits highly toxic fluorocarbon fumes. The primary route of human exposure to this compound is inhalation. Acute inhalation exposure to tetrafluoroethylene may result in irritation of the respiratory tract and buildup of fluid in the lungs (pulmonary edema). Contact with this gas can cause eye irritation. This chemical is reasonably anticipated to be a human carcinogen. (NCI05)
C44453	Tetranitromethane	Nitro-compound_Carcinogen	Tetranitromethane|TNM|Tetan	A synthetic, oily, colorless to pale yellow liquid that is insoluble in water and soluble in alcohol and ether. Tetranitromethane is used as an oxidizing agent in rocket propellants and explosives as well as an additive to increase the cetane number of diesel fuel. In science, it is used as both an analytical reagent for the detection of double bonds in organic compounds and as a mild nitrating reagent that reacts with tyrosine residues in proteins. The primary route of potential human exposure to tetranitromethane is inhalation. Acute inhalation exposure to tetranitromethane can result in irritation of the respiratory tract, buildup of fluid in the lungs (pulmonary edema) and interference with the oxygen-carrying capacity of red blood cells (methemoglobinemia). Contact with this compound can cause irritation of the eyes and skin. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44454	Thioacetamide	Organic_Carcinogen	Thioacetamide|Acetothioamide|Ethanethioamide|Sulfo-amine|TAA|Thioacetimidic Acid	A synthetic, colorless crystalline solid that is soluble in water and ethanol. Thioacetamide is currently only used as a replacement for hydrogen sulfide in qualitative analysis. When heated to decomposition, it emits toxic fumes of nitrogen oxides and sulfur oxides. The primary routes of potential human exposure to thioacetamide are inhalation and dermal contact. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44455	Thiourea	Organic_Carcinogen	Thiourea|2-Thiourea|Isothiourea|Pseudothiourea|Sulfourea|THU|Thiocarbamide|USAF EK-497	A white crystalline solid, both naturally occurring and synthetic, that is soluble in water, ammonium thiocyanate solution and ethanol. In the past, it was used as a photographic toning agent, a component of hair preparations and a dry cleaning agent. Currently, it is only used in animal glue liquefiers and silver tarnish removers. When heated to decomposition, thiourea emits toxic fumes of nitrogen oxides and sulfur oxides. Long-term exposure of humans to thiourea may cause bone marrow damage, resulting in reduced levels of red blood cells, white blood cells and/or platelets. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44456	Tobacco_Related_Exposure	Environmental_Exposure	Tobacco Related Exposure
C44457	Toluene_Diisocyanate	Carcinogenic_Aromatic_Amine	Toluene Diisocyanate|1,3-Diisocyanatomethylbenzene|Methyl-meta-phenylene Ester Isocyanic Acid|TDI	A synthetic mixture of the 2,4- and 2,6-isomers is a volatile, colorless to pale yellow liquid that is soluble in many organic solvents. These isomers are used primarily in the synthesis of polyurethane foams. When heated to decomposition, toluene diisocyanate emits toxic fumes of cyanides and nitrogen oxides. Exposure of humans to toluene diisocyanate causes tissue irritation, especially to the mucous membranes, and can produce severe respiratory problems. These isomers are reasonably anticipated to be human carcinogens. (NCI05)
C44458	Toxaphene	Carcinogenic_Chlorinated_Hydrocarbon	Toxaphene|Agricide Maggot Killer|Alltex|Attac 6|Attac 8|Camphochlor|Crestoxo|Estonox|Octachlorocamphene|Phenacide|Polychlorocamphene|Strobane-T|Toxadust|Toxyphen	A synthetic mixture of chlorinated camphenes with a yellow waxy appearance that is practically insoluble in water and soluble in aromatic hydrocarbons. Toxaphene had been used as a pesticide in the US before and all uses were banned in 1990. When heated to decomposition, toxaphene emits toxic fumes of hydrochloric acid and other chlorinated compounds. Exposure of humans to toxaphene causes stimulation of the central nervous system, which results in convulsive seizures. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44459	Trichloroethylene	Carcinogenic_Chlorinated_Hydrocarbon	Trichloroethylene|1,1-Dichloro-2-chloroethylene|Ethinyl Trichloride|Ethylene Trichloride|Trichloroethene	A synthetic, light sensitive, volatile, colorless, liquid that is miscible with many non-polar organic solvents. Trichloroethylene is used mainly as a degreaser for metal parts. Upon combustion, it produces irritants and toxic gases. Occupational exposure to trichloroethylene is associated with excess incidences of liver cancer, kidney cancer and non-Hodgkin's lymphoma. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44460	TRIS-BP	Organic_Carcinogen	TRIS-BP|2,3-Dibromo-1-propanol Phosphate(3:1)|Phosphoric Acid Tris(2,3-dibromopropyl) Ester|Tris|Tris(2,3-dibromopropyl) Phosphate	A synthetic, colorless or pale yellow liquid that is insoluble in water and miscible with carbon tetrachloride, chloroform and methylene chloride. TRIS-BP is no longer used in the United States. The primary routes of human exposure to TRIS-BP are inhalation, dermal contact and ingestion. Since this compound is no longer produced in the United States, the risk of exposure is low. However, TRIS-BP persists in fabric and plastics, making occupational and consumer exposure possible. Contact with this chemical can irritate the eyes and skin. It is reasonably anticipated to be a human carcinogen. (NCI05)
C44461	Ultraviolet_C_Radiation	Ultraviolet_Radiation	Ultraviolet C Radiation|UVC Radiation	Many scientists rate wavelengths in the C range of the ultraviolet (UVC) solar spectrum, between 200 and 290 nm, as the most carcinogenic. The ozone layer absorbs most UVC rays. Recent ozone depletion has permitted more UV radiation to reach the Earth's surface with a wide range of potentially damaging health effects related to skin, eyes, and immune system. (NCI04)
C44462	UV_Radiation_Exposure	Sun_Exposure	UV Radiation Exposure|Ultraviolet Radiation Related Exposures	The exposure to uv radiation via incident light from the sun.
C44463	Wood_Dust	Carcinogenic_Mixture	Wood Dust|Sanderdust|Sawdust|Wood Flour|Wood Meal	A light- to dark-colored granular solid mixture that is generated when timber is processed, such as when it is chipped, sawed, turned, drilled or sanded. The chemical composition of wood dust depends on the species of tree and consists mainly of cellulose, polyoses and lignin, with a large and variable number of substances with lower relative molecular mass. Wood dust is not typically produced for specific uses. However, it is used commercially for wood composts. The primary routes of potential human exposure to wood dust are inhalation and dermal contact. It is known to be a human carcinogen. (NCI05)
C44464	Carcinogen_Containing_Dye	Organic_Carcinogen	Carcinogen Containing Dye	A dye that consists of a carcinogenic nucleus that is attached to chromophores by azo-linkages and is broken down in vivo to form the free carcinogenic nucleus. (NCI05)
C44465	Coordinate	Conceptual_Entities	Coordinate|Coordinates	A number or other designation that identifies a position relative to an axis or grid.
C44466	Feature_Reporter_Map	UML_Entity	Feature Reporter Map	A FeatureReporterMap is the description of how source features are transformed into a target reporter.  These would map replicate features for a reporter to the reporter. (caMAGE)
C44467	Fiducial	General_Modifier	Fiducial|Fiduciary	Used as a fixed standard of reference for comparison or measurement.
C44468	Hardware_Application	UML_Entity	Hardware Application	The use of a piece of hardware with the requisite Parameters and ParameterValues. (caMAGE)
C44469	Identifiable_Class	UML_Entity	Identifiable Class|Identifiable	An Identifiable class is one that has an unambiguous reference within the scope.  It also has a potentially ambiguous name. (caMAGE)
C44470	Manufacture_LIMS	UML_Entity	Manufacture LIMS	Information on the physical production of arrays within the laboratory. (caMAGE)
C44471	Measured_Bioassay	UML_Entity	Measured Bioassay	A measured bioAssay is the direct processing of information in a physical bioAssay by the featureExtraction event.  Often uses images which are referenced through the physical bioAssay. (caMAGE)
C44473	Measured	General_Modifier	Measured	Having been determined by measurement.
C44474	Mismatch_Information	UML_Entity	Mismatch Information	Describes how a reporter varies from its ReporterCharacteristics sequence(s) or how a Feature varies from its Reporter sequence. (caMAGE)
C44475	Cluster_Node	UML_Entity	Cluster Node	An individual component of a clustering.  May contain other nodes. (caMAGE)
C44476	Content	Conceptual_Entities	Content|Contents	Everything that is included in a collection, container, or communication.
C44477	X-Coordinate	Coordinate	X-Coordinate|x	A horizontal coordinate that is used together with a vertical coordinate to specify an exact point in space.
C44478	Y-Coordinate	Coordinate	Y-Coordinate|y	A vertical coordinate that is used together with a horizontal coordinate to specify an exact point in space.
C44479	Z-Coordinate	Coordinate	Z-Coordinate|z	A third coordinate that is used together with horizontal (x) and vertical (y) coordinates to specify an exact point in a three dimensional space.
C44480	Isle_of_Man	Country	Isle of Man|833|IM|IMN	An enclave of Rome (Italy). (CIA World Factbook 2002)
C44481	Aland_Islands	Country	Aland Islands|248|ALA|AX|Ahvenanmaa|Ahvenanmaa Islands	 An archipelago in the Baltic Sea at the entrance to the Gulf of Bothnia between Sweden and Finland. (American Heritage Dictionary)
C44482	Christmas_Island	Country	Christmas Island|162|CX|CXR|KT	An Australian-administered island in the eastern Indian Ocean south of Java, Indonesia. (American Heritage Dictionary)
C44483	Applicable	General_Modifier	Applicable	Having relevance; capable of being applied.
C44486	Eyak	Aleut	Eyak
C44487	Koniag_Aleut	Aleut	Koniag Aleut
C44488	Sugpiaq	Aleut	Sugpiaq
C44489	Suqpigaq	Aleut	Suqpigaq
C44490	Unangan_Aleut	Aleut	Unangan Aleut
C44491	Chenega	Chugach_Aleut	Chenega
C44492	Chugach_Corporation	Chugach_Aleut	Chugach Corporation
C44493	English_Bay	Chugach_Aleut	English Bay
C44494	Port_Graham	Chugach_Aleut	Port Graham
C44495	Akhiok	Koniag_Aleut	Akhiok
C44496	Agdaagux	Koniag_Aleut	Agdaagux
C44497	Karluk	Koniag_Aleut	Karluk
C44498	Kodiak	Koniag_Aleut	Kodiak
C44499	Larsen_Bay	Koniag_Aleut	Larsen Bay
C44500	Old_Harbor	Koniag_Aleut	Old Harbor
C44501	Ouzinkie	Koniag_Aleut	Ouzinkie
C44502	Port_Lions	Koniag_Aleut	Port Lions
C44503	Gambell	Siberian_Eskimo	Gambell
C44504	Savoonga	Siberian_Eskimo	Savoonga
C44505	Siberian_Yupik	Siberian_Eskimo	Siberian Yupik
C44506	Cahto	California_Tribes	Cahto
C44507	Chimariko	California_Tribes	Chimariko
C44508	Coast_Miwok	California_Tribes	Coast Miwok
C44509	Digger	California_Tribes	Digger
C44510	Kawaiisu	California_Tribes	Kawaiisu
C44511	Kern_River	California_Tribes	Kern River
C44512	Mattole	California_Tribes	Mattole
C44513	Red_Wood	California_Tribes	Red Wood
C44514	Santa_Rosa	California_Tribes	Santa Rosa
C44515	Takelma	California_Tribes	Takelma
C44516	Wappo	California_Tribes	Wappo
C44517	Yana	California_Tribes	Yana
C44518	Yuki	California_Tribes	Yuki
C44519	Radiosensitization_Induction	Multicellular_Process	Radiosensitization Induction|Induction of Radiosensitization	The process via certain compounds with specific carrier to deliver to target anatomic structures for selectively enhancing radiation cytotoxicity. (NCI)
C44520	_17q21_31	Chromosome_Band	17q21.31	A chromosome band present on 17q
C44521	t_3_14_p14_1_q32	Chromosomal_Translocation	t(3;14)(p14.1;q32)
C44522	_18q21_32	Chromosome_Band	18q21.32	Part of the chromosome bands present on the long (q) arm of chromosome 18.
C44523	_11p14_3-p15_2	Chromosome_Band	11p14.3-p15.2	Part of the chromosome bands present on the short (p) arm of chromosome 11.
C44525	Campo	Diegueno	Campo
C44526	Capitan_Grande	Diegueno	Capitan Grande
C44527	Cuyapaipe	Diegueno	Cuyapaipe
C44528	La_Posta	Diegueno	La Posta
C44529	Manzanita	Diegueno	Manzanita
C44530	Mesa_Grande	Diegueno	Mesa Grande
C44531	San_Pasqual	Diegueno	San Pasqual
C44532	Santa_Ysabel	Diegueno	Santa Ysabel
C44533	Sycuan	Diegueno	Sycuan
C44534	Bishop	Paiute	Bishop
C44535	Bridgeport	Paiute	Bridgeport
C44536	Burns_Paiute	Paiute	Burns Paiute
C44537	Cedarville	Paiute	Cedarville
C44538	Fort_Bidwell	Paiute	Fort Bidwell
C44539	Fort_Independence	Paiute	Fort Independence
C44540	Kaibab	Paiute	Kaibab
C44541	Las_Vegas	Paiute	Las Vegas
C44542	Lone_Pine	Paiute	Lone Pine
C44543	Lovelock	Paiute	Lovelock
C44544	Malheur_Paiute	Paiute	Malheur Paiute
C44545	Moapa	Paiute	Moapa
C44546	Northern_Paiute	Paiute	Northern Paiute
C44547	Owens_Valley	Paiute	Owens Valley
C44548	Pyramid_Lake	Paiute	Pyramid Lake
C44549	San_Juan_Southern_Paiute	Paiute	San Juan Southern Paiute
C44550	Southern_Paiute	Paiute	Southern Paiute
C44551	Summit_Lake	Paiute	Summit Lake
C44552	Utu_Utu_Gwaitu_Paiute	Paiute	Utu Utu Gwaitu Paiute
C44553	Walker_River	Paiute	Walker River
C44554	Yerington_Paiute	Paiute	Yerington Paiute
C44555	Battle_Mountain	Shoshone	Battle Mountain
C44556	Duckwater	Shoshone	Duckwater
C44557	Elko	Shoshone	Elko
C44558	Ely	Shoshone	Ely
C44559	Goshute	Shoshone	Goshute
C44560	Panamint	Shoshone	Panamint
C44561	Ruby_Valley	Shoshone	Ruby Valley
C44562	Skull_Valley	Shoshone	Skull Valley
C44563	South_Fork_Shoshone	Shoshone	South Fork Shoshone
C44564	Te_Moak_Western_Shoshone	Shoshone	Te Moak Western Shoshone|Te-Moak Western Shoshone
C44565	Timbi_Sha_Shoshone	Shoshone	Timbi Sha Shoshone|Timbi-Sha Shoshone
C44566	Washakie	Shoshone	Washakie
C44567	Wind_River_Shoshone	Shoshone	Wind River Shoshone
C44568	Yomba	Shoshone	Yomba
C44569	Akiachak	Yupik_Eskimo	Akiachak
C44570	Akiak	Yupik_Eskimo	Akiak
C44571	Alakanuk	Yupik_Eskimo	Alakanuk
C44572	Aleknagik	Yupik_Eskimo	Aleknagik
C44573	Andreafsky	Yupik_Eskimo	Andreafsky
C44574	Aniak	Yupik_Eskimo	Aniak
C44575	Atmautluak	Yupik_Eskimo	Atmautluak
C44576	Bethel	Yupik_Eskimo	Bethel
C44577	Bill_Moore_s_Slough	Yupik_Eskimo	Bill Moore s Slough|Bill Moore's Slough
C44578	Bristol_Bay_Yupik	Yupik_Eskimo	Bristol Bay Yupik
C44579	Calista_Yupik	Yupik_Eskimo	Calista Yupik
C44580	Chefornak	Yupik_Eskimo	Chefornak
C44581	Chevak	Yupik_Eskimo	Chevak
C44582	Chuathbaluk	Yupik_Eskimo	Chuathbaluk
C44583	Clark_s_Point	Yupik_Eskimo	Clark s Point|Clark's Point
C44584	Crooked_Creek	Yupik_Eskimo	Crooked Creek
C44585	Dillingham	Yupik_Eskimo	Dillingham
C44586	Eek	Yupik_Eskimo	Eek
C44587	Ekuk	Yupik_Eskimo	Ekuk
C44588	Ekwok	Yupik_Eskimo	Ekwok
C44589	Emmonak	Yupik_Eskimo	Emmonak
C44590	Goodnews_Bay	Yupik_Eskimo	Goodnews Bay
C44591	Hooper_Bay	Yupik_Eskimo	Hooper Bay
C44592	Iqurmuit_Russian_Mission	Yupik_Eskimo	Iqurmuit Russian Mission|Iqurmuit (Russian Mission)
C44593	Kalskag	Yupik_Eskimo	Kalskag
C44594	Kasigluk	Yupik_Eskimo	Kasigluk
C44595	Kipnuk	Yupik_Eskimo	Kipnuk
C44596	Koliganek	Yupik_Eskimo	Koliganek
C44597	Kongiganak	Yupik_Eskimo	Kongiganak
C44598	Kotlik	Yupik_Eskimo	Kotlik
C44599	Kwethluk	Yupik_Eskimo	Kwethluk
C44600	Kwigillingok	Yupik_Eskimo	Kwigillingok
C44601	Levelock	Yupik_Eskimo	Levelock
C44602	Lower_Kalskag	Yupik_Eskimo	Lower Kalskag
C44603	Manokotak	Yupik_Eskimo	Manokotak
C44604	Marshall	Yupik_Eskimo	Marshall
C44605	Mekoryuk	Yupik_Eskimo	Mekoryuk
C44606	Mountain_Village	Yupik_Eskimo	Mountain Village
C44607	Naknek	Yupik_Eskimo	Naknek
C44608	Napaumute	Yupik_Eskimo	Napaumute
C44609	Napakiak	Yupik_Eskimo	Napakiak
C44610	Napaskiak	Yupik_Eskimo	Napaskiak
C44611	Newhalen	Yupik_Eskimo	Newhalen
C44612	New_Stuyahok	Yupik_Eskimo	New Stuyahok
C44613	Newtok	Yupik_Eskimo	Newtok
C44614	Nightmute	Yupik_Eskimo	Nightmute
C44615	Nunapitchukv	Yupik_Eskimo	Nunapitchukv
C44616	Oscarville	Yupik_Eskimo	Oscarville
C44617	Pilot_Station	Yupik_Eskimo	Pilot Station
C44618	Pitkas_Point	Yupik_Eskimo	Pitkas Point
C44619	Portage_Creek	Yupik_Eskimo	Portage Creek
C44620	Quinhagak	Yupik_Eskimo	Quinhagak
C44621	Red_Devil	Yupik_Eskimo	Red Devil
C44623	Scammon_Bay	Yupik_Eskimo	Scammon Bay
C44624	Sheldon_s_Point	Yupik_Eskimo	Sheldon s Point|Sheldon's Point
C44625	Sleetmute	Yupik_Eskimo	Sleetmute
C44626	Stebbins	Yupik_Eskimo	Stebbins
C44627	Togiak	Yupik_Eskimo	Togiak
C44628	Toksook	Yupik_Eskimo	Toksook
C44629	Tulukskak	Yupik_Eskimo	Tulukskak
C44630	Tuntutuliak	Yupik_Eskimo	Tuntutuliak
C44631	Tununak	Yupik_Eskimo	Tununak
C44632	Twin_Hills	Yupik_Eskimo	Twin Hills
C44633	Georgetown	Yupik_Eskimo	Georgetown
C44635	Umkumiate	Yupik_Eskimo	Umkumiate
C44636	Akutan	Unangan_Aleut	Akutan
C44637	Aleut_Corporation	Unangan_Aleut	Aleut Corporation
C44638	Aleutian_Islander	Unangan_Aleut	Aleutian Islander
C44639	Atka	Unangan_Aleut	Atka
C44640	Belkofski	Unangan_Aleut	Belkofski
C44641	Chignik_Lagoon	Unangan_Aleut	Chignik Lagoon
C44642	King_Cove	Unangan_Aleut	King Cove
C44643	False_Pass	Unangan_Aleut	False Pass
C44644	Nelson_Lagoon	Unangan_Aleut	Nelson Lagoon
C44645	Nikolski	Unangan_Aleut	Nikolski
C44646	Pauloff_Harbor	Unangan_Aleut	Pauloff Harbor
C44647	Qagan_Toyagungin	Unangan_Aleut	Qagan Toyagungin
C44648	Qawalangin	Unangan_Aleut	Qawalangin
C44651	Sand_Point	Unangan_Aleut	Sand Point
C44652	South_Naknek	Unangan_Aleut	South Naknek
C44653	Unalaska	Unangan_Aleut	Unalaska
C44654	Unga	Unangan_Aleut	Unga
C44655	Chignik	Bristol_Bay_Aleut	Chignik
C44656	Chignik_Lake	Bristol_Bay_Aleut	Chignik Lake
C44657	Egegik	Bristol_Bay_Aleut	Egegik
C44658	Igiugig	Bristol_Bay_Aleut	Igiugig
C44659	Ivanof_Bay	Bristol_Bay_Aleut	Ivanof Bay
C44660	King_Salmon	Bristol_Bay_Aleut	King Salmon
C44661	Kokhanok	Bristol_Bay_Aleut	Kokhanok
C44662	Perryville	Bristol_Bay_Aleut	Perryville
C44663	Pilot_Point	Bristol_Bay_Aleut	Pilot Point
C44664	Port_Heiden	Bristol_Bay_Aleut	Port Heiden
C44665	Ambler	Inupiat_Eskimo	Ambler
C44666	Anaktuvuk	Inupiat_Eskimo	Anaktuvuk
C44667	Anaktuvuk_Pass	Inupiat_Eskimo	Anaktuvuk Pass
C44668	Arctic_Slope_Inupiat	Inupiat_Eskimo	Arctic Slope Inupiat
C44669	Arctic_Slope_Corporation	Inupiat_Eskimo	Arctic Slope Corporation
C44670	Atqasuk	Inupiat_Eskimo	Atqasuk
C44671	Barrow	Inupiat_Eskimo	Barrow
C44672	Bering_Straits_Inupiat	Inupiat_Eskimo	Bering Straits Inupiat
C44673	Brevig_Mission	Inupiat_Eskimo	Brevig Mission
C44674	Buckland	Inupiat_Eskimo	Buckland
C44675	Chinik	Inupiat_Eskimo	Chinik
C44676	Council	Inupiat_Eskimo	Council
C44677	Deering	Inupiat_Eskimo	Deering
C44678	Elim	Inupiat_Eskimo	Elim
C44679	Golovin	Inupiat_Eskimo	Golovin
C44680	Inalik_Diamede	Inupiat_Eskimo	Inalik Diamede|Inalik Diomede
C44681	Inupiaq	Inupiat_Eskimo	Inupiaq|Inupiaq 
C44682	Kaktovik	Inupiat_Eskimo	Kaktovik
C44683	Kawerak	Inupiat_Eskimo	Kawerak
C44684	Kiana	Inupiat_Eskimo	Kiana
C44685	Kivalina	Inupiat_Eskimo	Kivalina
C44686	Kobuk	Inupiat_Eskimo	Kobuk
C44687	Kotzebue	Inupiat_Eskimo	Kotzebue
C44688	Koyuk	Inupiat_Eskimo	Koyuk
C44689	Kwiguk	Inupiat_Eskimo	Kwiguk
C44690	Mauneluk_Inupiat	Inupiat_Eskimo	Mauneluk Inupiat
C44691	Nana_Inupiat	Inupiat_Eskimo	Nana Inupiat
C44692	Noatak	Inupiat_Eskimo	Noatak
C44693	Nome	Inupiat_Eskimo	Nome
C44694	Noorvik	Inupiat_Eskimo	Noorvik
C44695	Nuiqsut	Inupiat_Eskimo	Nuiqsut
C44696	Point_Hope	Inupiat_Eskimo	Point Hope
C44697	Point_Lay	Inupiat_Eskimo	Point Lay
C44698	Selawik	Inupiat_Eskimo	Selawik
C44699	Shaktoolik	Inupiat_Eskimo	Shaktoolik
C44700	Shishmaref	Inupiat_Eskimo	Shishmaref
C44701	Shungnak	Inupiat_Eskimo	Shungnak
C44702	Solomon	Inupiat_Eskimo	Solomon
C44703	Teller	Inupiat_Eskimo	Teller
C44704	Unalakleet	Inupiat_Eskimo	Unalakleet
C44705	Wainwright	Inupiat_Eskimo	Wainwright
C44706	Wales	Inupiat_Eskimo	Wales
C44707	White_Mountain	Inupiat_Eskimo	White Mountain
C44708	White_Mountain_Inupiat	Inupiat_Eskimo	White Mountain Inupiat
C44709	Mary_s_Igloo	Inupiat_Eskimo	Mary s Igloo|Mary's Igloo
C44710	Angoon	Tlingit_Haida	Angoon
C44711	Central_Council_of_Tlingit_and_Haida_Tribes	Tlingit_Haida	Central Council of Tlingit and Haida Tribes
C44712	Chilkat	Tlingit_Haida	Chilkat
C44713	Chilkoot	Tlingit_Haida	Chilkoot
C44714	Craig	Tlingit_Haida	Craig
C44715	Douglas	Tlingit_Haida	Douglas
C44716	Haida	Tlingit_Haida	Haida
C44717	Hoonah	Tlingit_Haida	Hoonah
C44718	Hydaburg	Tlingit_Haida	Hydaburg
C44719	Kake	Tlingit_Haida	Kake
C44720	Kasaan	Tlingit_Haida	Kasaan
C44721	Kenaitze	Tlingit_Haida	Kenaitze
C44722	Ketchikan	Tlingit_Haida	Ketchikan
C44723	Klawock	Tlingit_Haida	Klawock
C44724	Pelican	Tlingit_Haida	Pelican
C44725	Petersburg	Tlingit_Haida	Petersburg
C44726	Saxman	Tlingit_Haida	Saxman
C44727	Sitka	Tlingit_Haida	Sitka
C44728	Tenakee_Springs	Tlingit_Haida	Tenakee Springs
C44729	Tlingit	Tlingit_Haida	Tlingit
C44730	Wrangell	Tlingit_Haida	Wrangell
C44731	Yakutat	Tlingit_Haida	Yakutat
C44732	Ahtna	Alaskan_Athabascan	Ahtna
C44733	Alatna	Alaskan_Athabascan	Alatna|Alatna 
C44734	Alexander	Alaskan_Athabascan	Alexander
C44735	Allakaket	Alaskan_Athabascan	Allakaket
C44736	Alanvik	Alaskan_Athabascan	Alanvik
C44737	Anvik	Alaskan_Athabascan	Anvik
C44738	Arctic	Alaskan_Athabascan	Arctic
C44739	Beaver	Alaskan_Athabascan	Beaver
C44740	Birch_Creek	Alaskan_Athabascan	Birch Creek
C44741	Cantwell	Alaskan_Athabascan	Cantwell
C44742	Chalkyitsik	Alaskan_Athabascan	Chalkyitsik
C44743	Chickaloon	Alaskan_Athabascan	Chickaloon
C44744	Chistochina	Alaskan_Athabascan	Chistochina
C44745	Chitina	Alaskan_Athabascan	Chitina
C44746	Circle_Tribe	Alaskan_Athabascan	Circle
C44747	Cook_Inlet	Alaskan_Athabascan	Cook Inlet
C44748	Copper_Center	Alaskan_Athabascan	Copper Center
C44749	Copper_River	Alaskan_Athabascan	Copper River
C44750	Dot_Lake	Alaskan_Athabascan	Dot Lake
C44751	Doyon	Alaskan_Athabascan	Doyon
C44752	Eagle	Alaskan_Athabascan	Eagle
C44753	Eklutna	Alaskan_Athabascan	Eklutna
C44754	Evansville	Alaskan_Athabascan	Evansville
C44755	Fort_Yukon	Alaskan_Athabascan	Fort Yukon
C44756	Gakona	Alaskan_Athabascan	Gakona
C44757	Galena	Alaskan_Athabascan	Galena
C44758	Grayling	Alaskan_Athabascan	Grayling
C44759	Gulkana	Alaskan_Athabascan	Gulkana
C44760	Healy_Lake	Alaskan_Athabascan	Healy Lake
C44761	Holy_Cross	Alaskan_Athabascan	Holy Cross
C44762	Hughes	Alaskan_Athabascan	Hughes
C44763	Huslia	Alaskan_Athabascan	Huslia
C44764	Iliamna	Alaskan_Athabascan	Iliamna
C44765	Kaltag	Alaskan_Athabascan	Kaltag
C44766	Kluti_Kaah	Alaskan_Athabascan	Kluti Kaah
C44767	Knik	Alaskan_Athabascan	Knik
C44768	Koyukuk	Alaskan_Athabascan	Koyukuk
C44769	Lake_Minchumina	Alaskan_Athabascan	Lake Minchumina
C44770	Lime	Alaskan_Athabascan	Lime
C44771	Mcgrath	Alaskan_Athabascan	Mcgrath
C44772	Manley_Hot_Springs	Alaskan_Athabascan	Manley Hot Springs
C44773	Mentasta_Lake	Alaskan_Athabascan	Mentasta Lake
C44774	Minto	Alaskan_Athabascan	Minto
C44775	Nenana	Alaskan_Athabascan	Nenana
C44776	Nikolai	Alaskan_Athabascan	Nikolai
C44777	Ninilchik	Alaskan_Athabascan	Ninilchik
C44778	Nondalton	Alaskan_Athabascan	Nondalton
C44779	Northway	Alaskan_Athabascan	Northway
C44780	Nulato	Alaskan_Athabascan	Nulato
C44781	Pedro_Bay	Alaskan_Athabascan	Pedro Bay
C44782	Rampart	Alaskan_Athabascan	Rampart
C44783	Ruby	Alaskan_Athabascan	Ruby
C44784	Salamatof	Alaskan_Athabascan	Salamatof
C44785	Seldovia	Alaskan_Athabascan	Seldovia
C44786	Slana	Alaskan_Athabascan	Slana
C44787	Shageluk	Alaskan_Athabascan	Shageluk
C44788	Stevens	Alaskan_Athabascan	Stevens
C44789	Stony_River	Alaskan_Athabascan	Stony River
C44790	Takotna	Alaskan_Athabascan	Takotna
C44791	Tanacross	Alaskan_Athabascan	Tanacross
C44792	Tanaina	Alaskan_Athabascan	Tanaina
C44793	Tanana	Alaskan_Athabascan	Tanana
C44794	Tanana_Chiefs	Alaskan_Athabascan	Tanana Chiefs
C44795	Tazlina	Alaskan_Athabascan	Tazlina
C44796	Telida	Alaskan_Athabascan	Telida
C44797	Tetlin	Alaskan_Athabascan	Tetlin
C44798	Tok	Alaskan_Athabascan	Tok
C44799	Tyonek	Alaskan_Athabascan	Tyonek
C44800	Venetie	Alaskan_Athabascan	Venetie
C44801	Wiseman	Alaskan_Athabascan	Wiseman
C44802	Duwamish	Puget_Sound_Salish	Duwamish
C44803	Kikiallus	Puget_Sound_Salish	Kikiallus
C44804	Lower_Skagit	Puget_Sound_Salish	Lower Skagit
C44805	Muckleshoot	Puget_Sound_Salish	Muckleshoot
C44806	Nisqually	Puget_Sound_Salish	Nisqually
C44807	Nooksack	Puget_Sound_Salish	Nooksack
C44808	Port_Madison	Puget_Sound_Salish	Port Madison
C44809	Puyallup	Puget_Sound_Salish	Puyallup
C44810	Samish	Puget_Sound_Salish	Samish
C44811	Sauk-Suiattle	Puget_Sound_Salish	Sauk-Suiattle
C44812	Skokomish	Puget_Sound_Salish	Skokomish
C44813	Skykomish	Puget_Sound_Salish	Skykomish
C44814	Snohomish	Puget_Sound_Salish	Snohomish
C44815	Snoqualmie	Puget_Sound_Salish	Snoqualmie
C44816	Squaxin_Island	Puget_Sound_Salish	Squaxin Island
C44817	Steilacoom	Puget_Sound_Salish	Steilacoom
C44818	Stillaguamish	Puget_Sound_Salish	Stillaguamish
C44819	Suquamish	Puget_Sound_Salish	Suquamish
C44820	Swinomish	Puget_Sound_Salish	Swinomish
C44821	Tulalip	Puget_Sound_Salish	Tulalip
C44822	Upper_Skagit	Puget_Sound_Salish	Upper Skagit
C44823	Acoma	Pueblo	Acoma
C44824	Arizona_Tewa	Pueblo	Arizona Tewa
C44825	Cochiti	Pueblo	Cochiti
C44826	Hopi	Pueblo	Hopi
C44827	Isleta	Pueblo	Isleta
C44828	Jemez	Pueblo	Jemez
C44829	Keres	Pueblo	Keres
C44830	Laguna	Pueblo	Laguna
C44831	Nambe	Pueblo	Nambe
C44832	Picuris	Pueblo	Picuris
C44833	Piro	Pueblo	Piro
C44834	Pojoaque	Pueblo	Pojoaque
C44835	San_Felipe	Pueblo	San Felipe
C44836	San_Ildefonso	Pueblo	San Ildefonso
C44837	San_Juan_Pueblo	Pueblo	San Juan Pueblo
C44838	San_Juan_De	Pueblo	San Juan De
C44839	San_Juan	Pueblo	San Juan
C44840	Sandia	Pueblo	Sandia
C44841	Santa_Ana	Pueblo	Santa Ana
C44842	Santa_Clara	Pueblo	Santa Clara
C44843	Santo_Domingo	Pueblo	Santo Domingo
C44844	Taos	Pueblo	Taos
C44845	Tesuque	Pueblo	Tesuque
C44846	Tewa	Pueblo	Tewa
C44847	Tigua	Pueblo	Tigua
C44848	Zia	Pueblo	Zia
C44849	Zuni	Pueblo	Zuni
C44850	Citzen_Band_Potawatomi	Potawatomi	Citzen Band Potawatomi|Citizen Band Potawatomi
C44851	Forest_County	Potawatomi	Forest County
C44852	Hannahville	Potawatomi	Hannahville
C44853	Huron_Potawatomi	Potawatomi	Huron Potawatomi
C44854	Pokagon_Potawatomi	Potawatomi	Pokagon Potawatomi
C44855	Prairie_Band	Potawatomi	Prairie Band
C44856	Wisconsin_Potawatomi	Potawatomi	Wisconsin Potawatomi
C44857	Central_Pomo	Pomo	Central Pomo
C44858	Dry_Creek	Pomo	Dry Creek
C44859	Eastern_Pomo	Pomo	Eastern Pomo
C44860	Kashia	Pomo	Kashia
C44861	Northern_Pomo	Pomo	Northern Pomo
C44862	Scotts_Valley	Pomo	Scotts Valley
C44863	Stonyford	Pomo	Stonyford
C44864	Sulphur_Bank	Pomo	Sulphur Bank
C44865	Cayuga	Iroquois	Cayuga
C44866	Mohawk	Iroquois	Mohawk
C44867	Oneida	Iroquois	Oneida
C44868	Onondaga	Iroquois	Onondaga
C44869	Seneca	Iroquois	Seneca
C44870	Seneca_Nation	Iroquois	Seneca Nation
C44871	Seneca-Cayuga	Iroquois	Seneca-Cayuga
C44872	Tonawanda_Seneca	Iroquois	Tonawanda Seneca
C44873	Tuscarora	Iroquois	Tuscarora
C44874	Wyandotte	Iroquois	Wyandotte
C44875	Attacapa	Eastern_Tribes	Attacapa
C44876	Biloxi	Eastern_Tribes	Biloxi
C44877	Moor	Eastern_Tribes	Moor
C44878	Nansemond	Eastern_Tribes	Nansemond
C44879	Natchez	Eastern_Tribes	Natchez
C44880	Nausu_Waiwash	Eastern_Tribes	Nausu Waiwash
C44881	Nipmuc	Eastern_Tribes	Nipmuc
C44882	Paugussett	Eastern_Tribes	Paugussett
C44883	Pocomoke_Acohonock	Eastern_Tribes	Pocomoke Acohonock
C44884	Southeastern_Indians	Eastern_Tribes	Southeastern Indians
C44885	Susquehanock	Eastern_Tribes	Susquehanock
C44886	Tunica_Biloxi	Eastern_Tribes	Tunica Biloxi
C44887	Waccamaw_Siousan	Eastern_Tribes	Waccamaw Siousan
C44888	Wicomico	Eastern_Tribes	Wicomico
C44889	Eastern_Delaware	Deleware_Indian	Eastern Delaware
C44890	Lenni_Lenape	Deleware_Indian	Lenni Lenape
C44891	Munsee	Deleware_Indian	Munsee
C44892	Oklahoma_Delaware	Deleware_Indian	Oklahoma Delaware
C44893	Rampough_Mountain	Deleware_Indian	Rampough Mountain
C44894	Sand_Hill	Deleware_Indian	Sand Hill
C44895	Alabama_Creek	Creek	Alabama Creek
C44896	Alabama_Quassarte	Creek	Alabama Quassarte
C44897	Eastern_Creek	Creek	Eastern Creek
C44898	Eastern_Muscogee	Creek	Eastern Muscogee
C44899	Kialegee	Creek	Kialegee
C44900	Lower_Muscogee	Creek	Lower Muscogee
C44901	Machis_Lower_Creek_Indian	Creek	Machis Lower Creek Indian
C44902	Poarch_Band	Creek	Poarch Band
C44903	Principal_Creek_Indian_Nation	Creek	Principal Creek Indian Nation
C44904	Star_Clan_of_Muscogee_Creeks	Creek	Star Clan of Muscogee Creeks
C44905	Thlopthlocco	Creek	Thlopthlocco
C44906	Tuckabachee	Creek	Tuckabachee
C44907	Bad_River	Chippewa	Bad River
C44908	Bay_Mills_Chippewa	Chippewa	Bay Mills Chippewa
C44909	Bois_Forte	Chippewa	Bois Forte
C44910	Burt_Lake_Chippewa	Chippewa	Burt Lake Chippewa
C44911	Fond_du_Lac	Chippewa	Fond du Lac
C44912	Grand_Portage	Chippewa	Grand Portage
C44913	Grand_Traverse_Band_of_Ottawa_Chippewa	Chippewa	Grand Traverse Band of Ottawa Chippewa
C44914	Keweenaw	Chippewa	Keweenaw
C44915	Lac_Courte_Oreilles	Chippewa	Lac Courte Oreilles
C44916	Lac_du_Flambeau	Chippewa	Lac du Flambeau
C44917	Lac_Vieux_Desert_Chippewa	Chippewa	Lac Vieux Desert Chippewa
C44918	Lake_Superior	Chippewa	Lake Superior
C44919	Leech_Lake	Chippewa	Leech Lake
C44920	Little_Shell_Chippewa	Chippewa	Little Shell Chippewa
C44921	Mille_Lacs	Chippewa	Mille Lacs
C44922	Minnesota_Chippewa	Chippewa	Minnesota Chippewa
C44923	Ontonagon	Chippewa	Ontonagon
C44924	Red_Cliff_Chippewa	Chippewa	Red Cliff Chippewa
C44925	Red_Lake_Chippewa	Chippewa	Red Lake Chippewa
C44926	Saginaw_Chippewa	Chippewa	Saginaw Chippewa
C44929	Sokoagon_Chippewa	Chippewa	Sokoagon Chippewa|Sokoagon Chippewa 
C44930	Turtle_Mountain	Chippewa	Turtle Mountain
C44931	White_Earth	Chippewa	White Earth
C44932	Clatsop	Chinook	Clatsop
C44934	Kathlamet	Chinook	Kathlamet
C44935	Upper_Chinook	Chinook	Upper Chinook
C44936	Wakiakum_Chinook	Chinook	Wakiakum Chinook
C44937	Willapa_Chinook	Chinook	Willapa Chinook
C44938	Wishram	Chinook	Wishram
C44939	Cherokee_Alabama	Cherokee	Cherokee Alabama
C44940	Cherokees_of_Northeast_Alabama	Cherokee	Cherokees of Northeast Alabama
C44941	Cherokees_of_Southeast_Alabama	Cherokee	Cherokees of Southeast Alabama
C44942	Eastern_Cherokee	Cherokee	Eastern Cherokee
C44943	Echota_Cherokee	Cherokee	Echota Cherokee
C44944	Etowah_Cherokee	Cherokee	Etowah Cherokee
C44946	Tuscola	Cherokee	Tuscola
C44947	United_Keetowah_Band_of_Cherokee	Cherokee	United Keetowah Band of Cherokee
C44948	Western_Cherokee	Cherokee	Western Cherokee
C44949	Canadian_Indian	Canadian_and_Latin_American_Indian	Canadian Indian
C44950	Central_American_Indian	Canadian_and_Latin_American_Indian	Central American Indian
C44951	French_American_Indian	Canadian_and_Latin_American_Indian	French American Indian
C44952	Mexican_American_Indian	Canadian_and_Latin_American_Indian	Mexican American Indian
C44953	South_American_Indian	Canadian_and_Latin_American_Indian	South American Indian
C44954	Spanish_American_Indian	Canadian_and_Latin_American_Indian	Spanish American Indian
C44955	Amyloidogenesis	Pathologic_Process	Amyloidogenesis	Amyloidogenesis is the formation or growth of amyloid structures, implicated in many human diseases including Alzheimer s disease (AD), Parkinson s disease (PD), type II diabetes, and spongiform encephalopathies. In these disease states, normally soluble proteins aggregate as amyloidogenic insoluble fibrils that accumulate in affected tissues or organs.
C44956	_12p13_11	Chromosome_Band	12p13.11	Part of the chromosome bands present on the short (p) arm of chromosome 12.
C44957	_14q13_3	Chromosome_Band	14q13.3	Part of the chromosome bands present on the long (q) arm of chromosome 14.
C44958	_15q22_33	Chromosome_Band	15q22.33	Part of the chromosome bands present on the long (q) arm of chromosome 15.
C44959	Chlamydia_Psittaci_Infection	Chlamydial_Infection	Chlamydia Psittaci Infection
C44960	Chlamydia_Psittaci-Related_Ocular_Adnexal_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Ocular_Adnexae_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Chlamydia Psittaci-Associated Ocular Adnexal Mucosa-Associated Lymphoid Tissue Lymphoma
C44961	_1_147365209-147360110	Chromosome_1_Physical_Location	1: 147365209-147360110	Physical location of MCL1_Gene
C44962	_1_148822584-148818055	Chromosome_1_Physical_Location	1: 148822584-148818055	Physical location of S100A11_Gene
C44963	_1_150143403-150146572	Chromosome_1_Physical_Location	1: 150143403-150146572	Physical location of S100A9_Gene
C44964	_1_150161148-150159257	Chromosome_1_Physical_Location	1: 150161148-150159257	Physical location of S100A12_Gene
C44965	_1_150176622-150175582	Chromosome_1_Physical_Location	1: 150176622-150175582	Physical location of S100A8_Gene
C44966	_1_150351379-150346660	Chromosome_1_Physical_Location	1: 150351379-150346660	Physical location of S100A2_Gene
C44967	_1_150763524-150759820	Chromosome_1_Physical_Location	1: 150763524-150759820	Physical location of JTB_Gene
C44968	_1_151190742-151253261	Chromosome_1_Physical_Location	1: 151190742-151253261	Physical location of IL6R_Gene
C44969	_1_153641739-153623738	Chromosome_1_Physical_Location	1: 153641739-153623738	Physical location of INSRR_Gene
C44970	_1_157825530-157822115	Chromosome_1_Physical_Location	1: 157825530-157822115	Physical location of USF1_Gene
C44971	_1_163921801-164117000	Chromosome_1_Physical_Location	1: 163921801-164117000	Physical location of POU2F1_Gene
C44972	_1_189276582-189280811	Chromosome_1_Physical_Location	1: 189276582-189280811	Physical location of RGS1_Gene
C44973	_1_189509828-189513060	Chromosome_1_Physical_Location	1: 189509828-189513060	Physical location of RGS2_Gene
C44974	_1_200897271-200891127	Chromosome_1_Physical_Location	1: 200897271-200891127	Physical location of KISS1_Gene
C44975	_1_203360610-203404720	Chromosome_1_Physical_Location	1: 203360610-203404720	Physical location of IL19_Gene
C44976	_1_203459184-203465879	Chromosome_1_Physical_Location	1: 203459184-203465879	Physical location of IL24_Gene
C44977	_1_222383571-222380718	Chromosome_1_Physical_Location	1: 222383571-222380718	Physical location of LEFTB_Gene
C44978	_1_233007606-233039037	Chromosome_1_Physical_Location	1: 233007606-233039037	Physical location of LGALS8_Gene
C44979	_1_32409019-32420854	Chromosome_1_Physical_Location	1: 32409019-32420854	Physical location of LCK_Gene
C44980	_1_3592286-3673013	Chromosome_1_Physical_Location	1: 3592286-3673013	Physical location of TP73_Gene
C44981	_1_40036668-40034495	Chromosome_1_Physical_Location	1: 40036668-40034495	Physical location of LMYC_Gene
C44982	_1_47367791-47361281	Chromosome_1_Physical_Location	1: 47367791-47361281	Physical location of MAP17_Gene
C44983	_1_52394062-52524379	Chromosome_1_Physical_Location	1: 52394062-52524379	Physical location of MADHIP_Gene
C44984	_1_58961806-58958486	Chromosome_1_Physical_Location	1: 58961806-58958486	Physical location of JUN_Gene
C44985	_1_61260314-61634057	Chromosome_1_Physical_Location	1: 61260314-61634057	Physical location of NFIA_Gene
C44986	_1_65064007-65012229	Chromosome_1_Physical_Location	1: 65064007-65012229	Physical location of JAK1_Gene
C44987	_1_65603007-65815197	Chromosome_1_Physical_Location	1: 65603007-65815197	Physical location of LEPR_Gene
C44988	_1_67485068-67574604	Chromosome_1_Physical_Location	1: 67485068-67574604	Physical location of IL12RB2_Gene
C44989	_10_6144278-6093512	Chromosome_10_Physical_Location	10: 6144278-6093512	Physical location of IL2RA_Gene
C44990	_10_95507668-95547906	Chromosome_10_Physical_Location	10: 95507668-95547906	Physical location of LGI1_Gene
C44991	_11_102100868-102088540	Chromosome_11_Physical_Location	11: 102100868-102088540	Physical location of MMP8_Gene
C44992	_11_102174104-102165861	Chromosome_11_Physical_Location	11: 102174104-102165861	Physical location of MMP1_Gene
C44993	_11_102219550-102211743	Chromosome_11_Physical_Location	11: 102219550-102211743	Physical location of MMP3_Gene
C44994	_11_111540050-111519186	Chromosome_11_Physical_Location	11: 111540050-111519186	Physical location of IL18_Gene
C44995	_11_123491321-123522829	Chromosome_11_Physical_Location	11: 123491321-123522829	Physical location of LOH11CR2A_Gene
C44996	_11_2139000-2137585	Chromosome_11_Physical_Location	11: 2139000-2137585	Physical location of INS_Gene
C44997	_11_33870412-33836701	Chromosome_11_Physical_Location	11: 33870412-33836701	Physical location of LMO2_Gene
C44998	_11_44543784-44597891	Chromosome_11_Physical_Location	11: 44543784-44597891	Physical location of KAI1_Gene
C44999	_11_47247535-47308158	Chromosome_11_Physical_Location	11: 47247535-47308158	Physical location of MADD_Gene
C45000	_11_6581588-6588677	Chromosome_11_Physical_Location	11: 6581588-6588677	Physical location of ILK_Gene
C45001	_12_10351684-10359227	Chromosome_12_Physical_Location	12: 10351684-10359227	Physical location of KLRD1_Gene
C45002	_12_10643431-10633039	Chromosome_12_Physical_Location	12: 10643431-10633039	Physical location of KLRA1_Gene
C45003	_12_116262302-116113699	Chromosome_12_Physical_Location	12: 116262302-116113699	Physical location of NOS1_Gene
C45004	_12_25295121-25249447	Chromosome_12_Physical_Location	12: 25295121-25249447	Physical location of KRAS2_Gene
C45005	_12_42439047-42468166	Chromosome_12_Physical_Location	12: 42439047-42468166	Physical location of IRAK4_Gene
C45006	_12_48765279-48780692	Chromosome_12_Physical_Location	12: 48765279-48780692	Physical location of SMARCD1_Gene
C45007	_12_53099272-53075315	Chromosome_12_Physical_Location	12: 53099272-53075315	Physical location of ITGA5_Gene
C45008	_12_53534588-53538370	Chromosome_12_Physical_Location	12: 53534588-53538370	Physical location of LOC118430_Gene
C45009	_12_54869544-54843396	Chromosome_12_Physical_Location	12: 54869544-54843396	Physical location of SMARCC2_Gene
C45010	_12_64869284-64928652	Chromosome_12_Physical_Location	12: 64869284-64928652	Physical location of IRAK3_Gene
C45011	_12_87476713-87393065	Chromosome_12_Physical_Location	12: 87476713-87393065	Physical location of KITLG_Gene
C45012	_12_9651758-9639137	Chromosome_12_Physical_Location	12: 9651758-9639137	Physical location of KLRB1_Gene
C45013	_13_107665883-107657795	Chromosome_13_Physical_Location	13: 107665883-107657795	Physical location of LIG4_Gene
C45014	_13_109236915-109204187	Chromosome_13_Physical_Location	13: 109236915-109204187	Physical location of IRS2_Gene
C45015	_13_110163084-110171422	Chromosome_13_Physical_Location	13: 110163084-110171422	Physical location of ING1_Gene
C45016	_13_20533654-20446577	Chromosome_13_Physical_Location	13: 20533654-20446577	Physical location of LATS2_Gene
C45017	_13_45654395-45598060	Chromosome_13_Physical_Location	13: 45654395-45598060	Physical location of LCP1_Gene
C45018	_14_22375633-22386643	Chromosome_14_Physical_Location	14: 22375633-22386643	Physical location of MMP14_Gene
C45019	_14_23852357-23855992	Chromosome_14_Physical_Location	14: 23852357-23855992	Physical location of LTB4R_Gene
C45020	_14_26136535-25984929	Chromosome_14_Physical_Location	14: 26136535-25984929	Physical location of NOVA1_Gene
C45021	_14_74148787-74034640	Chromosome_14_Physical_Location	14: 74148787-74034640	Physical location of LTBP2_Gene
C45022	_15_39593369-39583132	Chromosome_15_Physical_Location	15: 39593369-39583132	Physical location of LTK_Gene
C45023	_15_64466679-64570936	Chromosome_15_Physical_Location	15: 64466679-64570936	Physical location of MAP2K1_Gene
C45024	_15_64781738-64861380	Chromosome_15_Physical_Location	15: 64781738-64861380	Physical location of MADH6_Gene
C45025	_15_65145331-65270904	Chromosome_15_Physical_Location	15: 65145331-65270904	Physical location of MADH3_Gene
C45026	_15_79262255-79392157	Chromosome_15_Physical_Location	15: 79262255-79392157	Physical location of IL16_Gene
C45027	_16_27248888-27283596	Chromosome_16_Physical_Location	16: 27248888-27283596	Physical location of IL4R_Gene
C45028	_16_30391572-30442007	Chromosome_16_Physical_Location	16: 30391572-30442007	Physical location of ITGAL_Gene
C45029	_16_31178812-31251691	Chromosome_16_Physical_Location	16: 31178812-31251691	Physical location of ITGAM_Gene
C45030	_16_31274010-31301819	Chromosome_16_Physical_Location	16: 31274010-31301819	Physical location of ITGAX_Gene
C45031	_16_54070604-54097652	Chromosome_16_Physical_Location	16: 54070604-54097652	Physical location of MMP2_Gene
C45032	_16_78192112-78185751	Chromosome_16_Physical_Location	16: 78192112-78185751	Physical location of MAF_Gene
C45033	_16_87232502-87234383	Chromosome_16_Physical_Location	16: 87232502-87234383	Physical location of IL17C_Gene
C45034	_17_17340432-17338480	Chromosome_17_Physical_Location	17: 17340432-17338480	Physical location of RASD1_Gene
C45035	_17_22898282-22968585	Chromosome_17_Physical_Location	17: 22898282-22968585	Physical location of KSR_Gene
C45036	_17_23151682-23107920	Chromosome_17_Physical_Location	17: 23151682-23107920	Physical location of NOS2A_Gene
C45037	_17_32368612-23274607	Chromosome_17_Physical_Location	17: 32368612-23274607	Physical location of LHX1_Gene
C45038	_17_35591394-35605426	Chromosome_17_Physical_Location	17: 35591394-35605426	Physical location of Link-GEFII_plus_H1171Gene
C45039	_17_36057629-36037508	Chromosome_17_Physical_Location	17: 36057629-36037508	Physical location of SMARCE1_Gene
C45040	_17_36938160-36933396	Chromosome_17_Physical_Location	17: 36938160-36933396	Physical location of KRT19_Gene
C45041	_17_37181645-37164390	Chromosome_17_Physical_Location	17: 37181645-37164390	Physical location of JUP_Gene
C45042	_17_39265136-39233695	Chromosome_17_Physical_Location	17: 39265136-39233695	Physical location of MPP3_Gene
C45043	_17_39340415-39308258	Chromosome_17_Physical_Location	17: 39340415-39308258	Physical location of MPP2_Gene
C45044	_17_42686207-42745076	Chromosome_17_Physical_Location	17: 42686207-42745076	Physical location of ITGB3_Gene
C45045	_17_59274083-59263176	Chromosome_17_Physical_Location	17: 59274083-59263176	Physical location of SMARCD2_Gene
C45046	_17_64922434-65051067	Chromosome_17_Physical_Location	17: 64922434-65051067	Physical location of MAP2K6_Gene
C45047	_17_6599880-6619690	Chromosome_17_Physical_Location	17: 6599880-6619690	Physical location of XAF1_Gene
C45048	_17_71229111-71265494	Chromosome_17_Physical_Location	17: 71229111-71265494	Physical location of ITGB4_Gene
C45049	_17_74487656-74478932	Chromosome_17_Physical_Location	17: 74487656-74478932	Physical location of LGALS3BP_Gene
C45050	_17_77474382-77469438	Chromosome_17_Physical_Location	17: 77474382-77469438	Physical location of MAFG_Gene
C45051	_18_43710924-43621616	Chromosome_18_Physical_Location	18: 43710924-43621616	Physical location of MADH2_Gene
C45052	_18_44731079-44700221	Chromosome_18_Physical_Location	18: 44731079-44700221	Physical location of MADH7_Gene
C45053	_18_46810611-4680145	Chromosome_18_Physical_Location	18: 46810611-4680145	Physical location of MADH4_Gene
C45054	_18_55718217-55722517	Chromosome_18_Physical_Location	18: 55718217-55722517	Physical location of PMAIP1_Gene
C45055	_19_10932606-11033953	Chromosome_19_Physical_Location	19: 10932606-11033953	Physical location of SMARCA4_Gene
C45056	_19_11061132-11105490	Chromosome_19_Physical_Location	19: 11061132-11105490	Physical location of LDLR_Gene
C45057	_19_12763310-12765125	Chromosome_19_Physical_Location	19: 12763310-12765125	Physical location of JUNB_Gene
C45058	_19_12996776-13066584	Chromosome_19_Physical_Location	19: 12996776-13066584	Physical location of NFIX_Gene
C45059	_19_13074681-13070848	Chromosome_19_Physical_Location	19: 13074681-13070848	Physical location of LYL1_Gene
C45060	_19_18058697-18031704	Chromosome_19_Physical_Location	19: 18058697-18031704	Physical location of IL12RB1_Gene
C45061	_19_18253468-18251570	Chromosome_19_Physical_Location	19: 18253468-18251570	Physical location of JUND_Gene
C45062	_19_18719800-17797961	Chromosome_19_Physical_Location	19: 18719800-17797961	Physical location of JAK3_Gene
C45063	_19_3310616-3414603	Chromosome_19_Physical_Location	19: 3310616-3414603	Physical location of NFIC-Gene
C45064	_19_40451736-40462558	Chromosome_19_Physical_Location	19: 40451736-40462558	Physical location of USF2_Gene
C45065	_19_414665-369928	Chromosome_19_Physical_Location	19: 414665-369928	Physical location of SLI_Gene
C45066	_19_47328422-47286963	Chromosome_19_Physical_Location	19: 47328422-47286963	Physical location of POU2F2_Gene
C45067	_19_51168497-51134631	Chromosome_19_Physical_Location	19: 51168497-51134631	Physical location of NOVA2_Gene
C45068	_19_54860926-54854641	Chromosome_19_Physical_Location	19: 54860926-54854641	Physical location of IRF3_Gene
C45069	_19_56026591-56020357	Chromosome_19_Physical_Location	19: 56026591-56020357	Physical location of KLK15_Gene
C45070	_19_56049983-56055832	Chromosome_19_Physical_Location	19: 56049983-56055832	Physical location of KLK3_Gene
C45071	_19_56068501-56073673	Chromosome_19_Physical_Location	19: 56068501-56073673	Physical location of KLK2_Gene
C45072	_19_7245011-7067638	Chromosome_19_Physical_Location	19: 7245011-7067638	Physical location of INSR_Gene
C45073	_2_100179488-99626334	Chromosome_2_Physical_Location	2: 100179488-99626334	Physical location of LAF4_Gene
C45074	_2_102066824-102103403	Chromosome_2_Physical_Location	2: 102066824-102103403	Physical location of IL1R2_Gene
C45075	_2_102228920-102254852	Chromosome_2_Physical_Location	2: 102228920-102254852	Physical location of IL1R1_Gene
C45076	_2_108553285-108759407	Chromosome_2_Physical_Location	2: 108553285-108759407	Physical location of LIMS1_Gene
C45077	_2_113259202-113247724	Chromosome_2_Physical_Location	2: 113259202-113247724	Physical location of IL1A_Gene
C45078	_2_113310587-113303568	Chromosome_2_Physical_Location	2: 113310587-113303568	Physical location of IL1B_Gene
C45079	_2_120819229-120825204	Chromosome_2_Physical_Location	2: 120819229-120825204	Physical location of INHBB_Gene
C45080	_2_218816252-218827481	Chromosome_2_Physical_Location	2: 218816252-218827481	Physical location of IL8RB_Gene
C45081	_2_218857222-218853076	Chromosome_2_Physical_Location	2: 218857222-218853076	Physical location of IL8RA_Gene
C45082	_2_219548961-219564457	Chromosome_2_Physical_Location	2: 219548961-219564457	Physical location of WNT6_Gene
C45083	_2_219570760-219584156	Chromosome_2_Physical_Location	2: 219570760-219584156	Physical location of WNT10A_Gene
C45084	_2_220262459-220265932	Chromosome_2_Physical_Location	2: 220262459-220265932	Physical location of INHA_Gene
C45085	_2_227489980-227425443	Chromosome_2_Physical_Location	2: 227489980-227425443	Physical location of IRS1_Gene
C45086	_2_70053968-70077256	Chromosome_2_Physical_Location	2: 70053968-70077256	Physical location of MAD_Gene
C45087	_20_1548630-1491568	Chromosome_20_Physical_Location	20: 1548630-1491568	Physical location of SIRPB1_Gene
C45088	_20_1823425-1868537	Chromosome_20_Physical_Location	20: 1823425-1868537	Physical location of PTPNS1_Gene
C45089	_20_44070954-44078606	Chromosome_20_Physical_Location	20: 44070954-44078606	Physical location of MMP9_Gene
C45090	_21_45165232-45130314	Chromosome_21_Physical_Location	21: 45165232-45130314	Physical location of ITGB2_Gene
C45091	_22_22439590-22451056	Chromosome_22_Physical_Location	22: 22439590-22451056	Physical location of MMP11_Gene
C45092	_22_22453764-22501255	Chromosome_22_Physical_Location	22: 22453764-22501255	Physical location of SMARCB1_Gene
C45093	_22_28967302-28960997	Chromosome_22_Physical_Location	22: 28967302-28960997	Physical location of LIF_Gene
C45094	_22_35870462-35846382	Chromosome_22_Physical_Location	22: 35870462-35846382	Physical location of IL2RB_Gene
C45095	_3_10181630-10255723	Chromosome_3_Physical_Location	3: 10181630-10255723	Physical location of IRAK2_Gene
C45096	_3_150287015-150230612	Chromosome_3_Physical_Location	3: 150287015-150230612	Physical location of SMARCA3_Gene
C45097	_3_184363325-184322706	Chromosome_3_Physical_Location	3: 184363325-184322706	Physical location of LAMP3_Gene
C45098	_3_187917822-187944445	Chromosome_3_Physical_Location	3: 187917822-187944445	Physical location of KNG_Gene
C45099	_3_3127031-3086421	Chromosome_3_Physical_Location	3: 3127031-3086421	Physical location of IL5RA_Gene
C45100	_3_39423209-39428929	Chromosome_3_Physical_Location	3: 39423209-39428929	Physical location of LAMR1_Gene
C45101	_3_4510137-4864081	Chromosome_3_Physical_Location	3: 4510137-4864081	Physical location of ITPR1_Gene
C45102	_3_45611355-45696569	Chromosome_3_Physical_Location	3: 45611355-45696569	Physical location of LIMD1_Gene
C45103	_3_47798410-47602391	Chromosome_3_Physical_Location	3: 47798410-47602391	Physical location of SMARCC1_Gene
C45104	_3_49041832-49036767	Chromosome_3_Physical_Location	3: 49041832-49036767	Physical location of IMPDH2_Gene
C45105	_4_123735485-123730230	Chromosome_4_Physical_Location	4: 123735485-123730230	Physical location of IL2_Gene
C45106	_4_142915359-143012217	Chromosome_4_Physical_Location	4: 142915359-143012217	Physical location of IL15_Gene
C45107	_4_144792221-144832172	Chromosome_4_Physical_Location	4: 144792221-144832172	Physical location of SMARCA5_Gene
C45108	_4_185770852-185684064	Chromosome_4_Physical_Location	4: 185770852-185684064	Physical location of IRF2_Gene
C45109	_4_55832690-55785577	Chromosome_4_Physical_Location	4: 55832690-55785577	Physical location of KDR_Gene
C45110	_4_6803638-6816969	Chromosome_4_Physical_Location	4: 6803638-6816969	Physical location of S100P_Gene
C45111	_4_74971310-74974468	Chromosome_4_Physical_Location	4: 74971310-74974468	Physical location of IL8_Gene
C45112	_4_75218935-75217793	Chromosome_4_Physical_Location	4: 75218935-75217793	Physical location of PPBP_Gene
C45113	_5_121441853-121429918	Chromosome_5_Physical_Location	5: 121441853-121429918	Physical location of LOX_Gene
C45114	_5_126140732-126200608	Chromosome_5_Physical_Location	5: 126140732-126200608	Physical location of LMNB1_Gene
C45115	_5_131424246-131426795	Chromosome_5_Physical_Location	5: 131424246-131426795	Physical location of IL3_Gene
C45116	_5_131854326-131846679	Chromosome_5_Physical_Location	5: 131854326-131846679	Physical location of IRF1_Gene
C45117	_5_131907113-131905035	Chromosome_5_Physical_Location	5: 131907113-131905035	Physical location of IL5_Gene
C45118	_5_132021764-132024700	Chromosome_5_Physical_Location	5: 132021764-132024700	Physical location of IL13_Gene
C45119	_5_132037272-132046267	Chromosome_5_Physical_Location	5: 132037272-132046267	Physical location of IL4_Gene
C45120	_5_135259415-135255834	Chromosome_5_Physical_Location	5: 135259415-135255834	Physical location of IL9_Gene
C45121	_5_156540485-156614687	Chromosome_5_Physical_Location	5: 156540485-156614687	Physical location of ITK_Gene
C45122	_5_169657400-169607667	Chromosome_5_Physical_Location	5: 169657400-169607667	Physical location of LCP2_Gene
C45123	_5_35892748-35912681	Chromosome_5_Physical_Location	5: 35892748-35912681	Physical location of IL7R_Gene
C45124	_5_38631253-38515662	Chromosome_5_Physical_Location	5: 38631253-38515662	Physical location of LIFR_Gene
C45125	_5_55326520-55272452	Chromosome_5_Physical_Location	5: 55326520-55272452	Physical location of IL6ST_Gene
C45126	_6_150131506-150023744	Chromosome_6_Physical_Location	6: 150131506-150023744	Physical location of LATS1_Gene
C45127	_6_31648072-31650077	Chromosome_6_Physical_Location	6: 31648072-31650077	Physical location of LTA_Gene
C45128	_6_31651329-31654091	Chromosome_6_Physical_Location	6: 31651329-31654091	Physical location of TNF_Gene
C45129	_6_31658181-31656314	Chromosome_6_Physical_Location	6: 31658181-31656314	Physical location of LTB_Gene
C45130	_6_32914499-32897588	Chromosome_6_Physical_Location	6: 32914499-32897588	Physical location of TAP2_Gene
C45131	_6_32929729-32920965	Chromosome_6_Physical_Location	6: 32929729-32920965	Physical location of TAP1_Gene
C45132	_6_336760-3356193	Chromosome_6_Physical_Location	6: 336760-3356193	Physical location of IRF4_Gene
C45133	_6_52159144-52163395	Chromosome_6_Physical_Location	6: 52159144-52163395	Physical location of IL17_Gene
C45134	_7_127644257-127626283	Chromosome_7_Physical_Location	7: 127644257-127626283	Physical location of IMPDH1_Gene
C45135	_7_150409988-150373707	Chromosome_7_Physical_Location	7: 150409988-150373707	Physical location of SMARCD3_Gene
C45136	_7_22540060-22544856	Chromosome_7_Physical_Location	7: 22540060-22544856	Physical location of IL6_Gene
C45137	_7_23283235-23123069	Chromosome_7_Physical_Location	7: 23283235-23123069	Physical location of KOC1_Gene
C45138	_7_41513299-41502036	Chromosome_7_Physical_Location	7: 41513299-41502036	Physical location of INHBA_Gene
C45139	_7_72942807-72981505	Chromosome_7_Physical_Location	7: 72942807-72981505	Physical location of LIMK1_Gene
C45140	_8_144171300-144175199	Chromosome_8_Physical_Location	8: 144171300-144175199	Physical location of LY6E_Gene
C45141	_8_56954926-57085685	Chromosome_8_Physical_Location	8: 56954926-57085685	Physical location of LYN_Gene
C45142	_8_79880313-79807561	Chromosome_8_Physical_Location	8: 79880313-79807561	Physical location of IL7_Gene
C45143	_9_123853443-123874996	Chromosome_9_Physical_Location	9: 123853443-123874996	Physical location of LHX2_Gene
C45144	_9_131642479-131481711	Chromosome_9_Physical_Location	9: 131642479-131481711	Physical location of RAPGEF1_Gene
C45145	_9_133026115-133002662	Chromosome_9_Physical_Location	9: 133026115-133002662	Physical location of RALGDS_Gene
C45146	_9_14303719-14077373	Chromosome_9_Physical_Location	9: 14303719-14077373	Physical location of NFIB_Gene
C45147	_9_2005342-2183620	Chromosome_9_Physical_Location	9: 2005342-2183620	Physical location of SMARCA2_Gene
C45148	_9_4975245-5117995	Chromosome_9_Physical_Location	9: 4975245-5117995	Physical location of JAK2_Gene
C45149	_9_5221419-5223967	Chromosome_9_Physical_Location	9: 5221419-5223967	Physical location of INSL4_Gene
C45150	_X_107785796-107781857	Chromosome_X_Physical_Location	X: 107785796-107781857	Physical location of IRS4_Gene
C45151	_X_117643441-117710378	Chromosome_X_Physical_Location	X: 117643441-117710378	Physical location of IL13RA1_Gene
C45152	_X_128382976-128306013	Chromosome_X_Physical_Location	X: 128382976-128306013	Physical location of SMARCA1_Gene
C45153	_X_1499188-1545409	Chromosome_X_Physical_Location	X: 1499188-1545409	Physical location of IL3RA_Gene
C45154	_X_151573740-151569863	Chromosome_X_Physical_Location	X: 151573740-151569863	Physical location of MAGEA12_Gene
C45155	_X_151608808-151605221	Chromosome_X_Physical_Location	X: 151608808-151605221	Physical location of MAGEA3_Gene
C45156	_X_152806189-152796809	Chromosome_X_Physical_Location	X: 152806189-152796809	Physical location of IRAK1_Gene
C45157	_X_153597467-153570672	Chromosome_X_Physical_Location	X: 153597467-153570672	Physical location of MPP1_Gene
C45158	_X_51469782-51478486	Chromosome_X_Physical_Location	X: 51469782-51478486	Physical location of MAGED1_Gene
C45159	_X_70114424-70110580	Chromosome_X_Physical_Location	X: 70114424-70110580	Physical location of IL2RG_Gene
C45160	_Y_9897925-9900718	Chromosome_Y_Physical_Location	Y: 9897925-9900718	Physical location of TSPY_Gene
C45161	Borrelia_Burgdoferi_Infection	Bacterial_Infection	Borrelia Burgdoferi Infection
C45162	_16q24_1	Chromosome_Band	16q24.1	Part of the chromosome bands present on the long (q) arm of chromosome 16.
C45163	Borrelia_Burgdoferi-Related_Cutaneous_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue	Bacterium-Related_Malignant_Neoplasm|Cutaneous_Marginal_Zone_B_Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue	Borrelia Burgdoferi-Associated Cutaneous Marginal Zone B-Cell Lymphoma of Mucosa-Associated Lymphoid Tissue
C45164	_17q21_1-q21_2	Chromosome_Band	17q21.1-q21.2	Part of the chromosome bands present on the long (q) arm of chromosome 17.
C45165	_9q34_11	Chromosome_Band	9q34.11	Part of the chromosome bands present on the long (q) arm of chromosome 9.
C45166	Campylobacter_Jejuni-Related_Small_Intestinal_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Bacterium-Related_Malignant_Neoplasm|Small_Intestinal_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Campylobacter Jejuni-Associated Small Intestinal Mucosa-Associated Lymphoid Tissue Lymphoma
C45167	_1q25_2	Chromosome_Band	1q25.2	Part of the chromosome bands present on the long (q) arm of chromosome 1.
C45168	_2p25_1	Chromosome_Band	2p25.1	Part of the chromosome bands present on the short (p) arm of chromosome 2.
C45169	_2q31_1	Chromosome_Band	2q31.1	Part of the chromosome bands present on the long (q) arm of chromosome 2.
C45170	Aleut	Alaska_Native	Aleut
C45171	_3q13_2	Chromosome_Band	3q13.2	Part of the chromosome bands present on the long (q) arm of chromosome 3.
C45172	_3q27_1	Chromosome_Band	3q27.1	Part of the chromosome bands present on the long (q) arm of chromosome 3.
C45173	Primary_Cutaneous_Lymphoma	Retired_Concepts	Primary Cutaneous Lymphoma
C45174	Inorganic_Carcinogen	Chemical_Carcinogen	Inorganic Carcinogen	A substance with carcinogenic potential that does not have carbon or its derivatives incorporated in its structure. (NCI05)
C45175	Organic_Carcinogen	Chemical_Carcinogen	Organic Carcinogen	A substance that can increase human cancer risk and contains carbon and its derivatives. Many of these carcinogenic chemicals will frequently contain hydrogen with or without oxygen, nitrogen, sulfur, phosphorus, and other elements. They exist in either carbon chain or carbon ring form. (NCI05)
C45176	Organo-nitrogen_Carcinogen	Organic_Carcinogen	Organo-nitrogen Carcinogen	An organic carcinogen having a C-N bond incorporated in its structure. (NCI05)
C45177	Carcinogenic_Anthraquinone	Organic_Carcinogen	Carcinogenic Anthraquinone	A compound that increases the risk of human cancer and is mainly used in the manufacture of dyes. These compounds consist of an anthracene ring that contains two ketone moieties in any position and can be substituted in any position except on the ketone groups. (NCI05)
C45178	Carcinogenic_Aromatic_Amine	Organo-nitrogen_Carcinogen	Carcinogenic Aromatic Amine	Potentially cancer-causing compound containing amine with an aromatic ring substituted for one or more of its hydrogen atoms, i.e., -NH2, -NH- or nitrogen group(s) attached to an aromatic hydrocarbon, whose structure usually contains one or more benzene rings. This group includes many industrial and tobacco carcinogens. (NCI05)
C45179	Nitro-compound_Carcinogen	Organo-nitrogen_Carcinogen	Nitro-compound Carcinogen	An organic compound with a cyclic or non-cyclic structure with single, double bonds or both that contains the monovalent group, -NO2, linked to a carbon atom and exposure to one of these compounds may increase human cancer risk. (NCI05)
C45180	Heterocyclic_Amine_Carcinogen	Organo-nitrogen_Carcinogen	Heterocyclic Amine Carcinogen	A cyclic compound that has at least one nitrogen incorporated into its structure instead of carbon and contains an amino (-NH2) group. Heterocyclic Amines are formed from cooking meat such as beef, pork, fowl, and fish when amino acids and creatine (found in muscle) react at high temperatures. Because of the high temperatures used, frying, broiling, and barbecuing produce the largest amounts of heterocyclic amines. These compounds that result from cooking meat may increase human cancer risk. (NCI05)
C45181	Nitroso_Carcinogen	Organo-nitrogen_Carcinogen	Nitroso Carcinogen	A compound with carcinogenic properties that contains an -NO group. (NCI05)
C45182	Nitroarene_Carcinogen	Nitro-compound_Carcinogen	Nitroarene Carcinogen	Potentially cancer-causing compound containing carbon and hydrogen in the form of an unsaturated, usually hexagonal, ring structure with one or more nitro-group(s), -NO2, attached to one or more aromatic ring(s). The compounds can be single ring, or double, triple, or multiple fused rings. These compounds are normally found in particulate emissions from many combustion sources, like diesel exhaust. (NCI05)
C45183	Organo-halide_Carcinogen	Organic_Carcinogen	Organo-halide Carcinogen	A compound with carcinogenic activity that has a carbon-based backbone that may be a cyclic or non-cyclic structure with single, double or triple bonds and can have other elements besides hydrogen incorporated in its structure but has at least one halogen (chloride, bromide, fluoride, iodide, and astatine) atom substituted for one of the hydrogen atoms. (NCI05)
C45184	Carcinogenic_Halogenated_Hydrocarbon	Organo-halide_Carcinogen	Carcinogenic Halogenated Hydrocarbon	Molecules with carcinogenic activity that almost entirely consist of carbon and hydrogen that may be cyclic or non-cyclic structures with single, double bonds or both but have at least one halogen element (chloride, bromide, fluoride, iodide, astatine) atom substituted for one of the hydrogen atoms. (NCI05)
C45185	Carcinogenic_Halogenated_Aromatic_Hydrocarbon	Organo-halide_Carcinogen	Carcinogenic Halogenated Aromatic Hydrocarbon	A compound that can increase human cancer risk and consists of hydrogen and carbon atoms arranged in a symmetrical 6-carbon ring structure with single and double bonds alternating around the ring (benzene ring) and in which at least one of the hydrogen atoms is substituted for a halogen (chlorine, bromine, fluorine) atom. These carcinogenic compounds can have single, double or multiple fused rings and can have other chemical groups attached to them in place of hydrogen. (NCI05)
C45186	Halogenated_Ring_Carcinogen	Organo-halide_Carcinogen	Halogenated Ring Carcinogen	A cyclic compound in which at least one hydrogen is replaced by a halogen (chlorine, bromine, iodine, fluorine, astatine) and exposure to this compound can increase the risk human cancer. (NCI05)
C45187	Cyclic_Ether_Carcinogen	Organic_Carcinogen	Cyclic Ether Carcinogen	A cyclic compound in which two carbon atoms are linked through an oxygen atom and exposure to these compounds can increase the risk of cancer in humans. (NCI05)
C45188	Carcinogenic_Polycyclic_Aromatic_Hydrocarbon	Carcinogenic_Hydrocarbon	Carcinogenic Polycyclic Aromatic Hydrocarbon	Carcinogenic Polycyclic Aromatic Hydrocarbons (PAH) are ubiquitous environmental pollutants that are formed in the process of incomplete burning of organic material and can cause cancer in humans. PAH molecules are made up of two or more fused aromatic rings. PAH causes a carcinogenic effect by metabolic activation to diol epoxides, which bind covalently to DNA. (NCI05)
C45189	Carcinogenic_Mixture	Chemical_Carcinogen	Carcinogenic Mixture	A compound that consists of a combination of more than one substance that can cause cancer in humans. (NCI05)
C45190	Organo-sulfur_Carcinogen	Organic_Carcinogen	Organo-sulfur Carcinogen	An organic compound that has sulfur incorporated into its structure and exposure to this compound can increase the risk of human cancer. (NCI05)
C45191	Primary_Cutaneous_B-Cell_Non-Hodgkin_s_Lymphoma	Retired_Concepts	Primary Cutaneous B-Cell Non-Hodgkin's Lymphoma
C45192	Primary_Cutaneous_T-Cell_Non-Hodgkin_s_Lymphoma	Retired_Concepts	Primary Cutaneous T-Cell Non-Hodgkin's Lymphoma
C45193	Primary_Cutaneous_Diffuse_Large_B-Cell_Lymphoma	Cutaneous_B-Cell_Lymphoma|Diffuse_Large_B-Cell_Lymphoma	Primary Cutaneous Diffuse Large B-Cell Lymphoma
C45194	Primary_Cutaneous_Diffuse_Large_B-Cell_Lymphoma_Leg_Type	Aggressive_Non-Hodgkin_s_Lymphoma|Primary_Cutaneous_Diffuse_Large_B-Cell_Lymphoma	Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type	An aggressive primary cutaneous B-cell lymphoma, usually involving the lower leg.  It is composed of a generally monotonous proliferation of immunoblasts, or less frequently centroblasts, with few admixed reactive cells.  This type of lymphoma occurs most often in elderly women who present with rapidly growing tumors, usually on one or both legs.  Dissemination to extracutaneous sites is frequent.  Treatment with combination chemotherapy is usually required.
C45195	_5p14-p13	Chromosome_Band	5p14-p13	Part of the chromosome bands present on the short (p) arm of chromosome 5.
C45196	_6p12_1	Chromosome_Band	6p12.1	A chromosome band present on 6p
C45197	_7q22_3	Chromosome_Band	7q22.3	A chromosome band present on 7q
C45198	Xp11_22-p11_21	Chromosome_Band	Xp11.22-p11.21	A chromosome band present on Xp
C45199	Xp11_4-p11_2	Chromosome_Band	Xp11.4-p11.2	A chromosome band present on Xp
C45200	Xq27	Chromosome_Band	Xq27	A chromosome band present on Xq
C45201	_3q23-q24	Chromosome_Band	3q23-q24	A chromosome band present on 3q
C45202	Low_Grade_Fibromyxoid_Sarcoma	Soft_Tissue_Fibrosarcoma	Low Grade Fibromyxoid Sarcoma	An indolent, late-metastasizing variant of fibrosarcoma characterized by alternating fibrous and myxoid areas and a whorling growth pattern.  The neoplastic cells have a spindle morphology, and lack hyperchromasia or significant nuclear atypia.  Approximately 40% of cases show the focal presence of collagen rosettes.  A consistent, balanced t(7;16)(q32-34;p11) translocation has been identified, associated with the presence of FUS-CREB3L2 fusion protein.  Most recent evidence suggests that rare cases may express the FUS-CREB3L1 fusion protein.
C45203	Low_Grade_Fibromyxoid_Sarcoma_with_Giant_Collagen_Rosettes	Low_Grade_Fibromyxoid_Sarcoma	Low Grade Fibromyxoid Sarcoma with Giant Collagen Rosettes	A fibromyxoid sarcoma with particularly prominent and well formed collagen rosettes.  The behavior of this subtype of fibromyxoid sarcoma is identical to classical low grade fibromyxoid sarcoma.
C45204	Collagen_Rosette_Formation	Rosette_Formation	Collagen Rosette Formation
C45205	Prominent_Collagen_Rosette_Formation	Collagen_Rosette_Formation	Prominent Collagen Rosette Formation
C45206	t_7_16_q32-34_p11	Chromosomal_Translocation	t(7;16)(q32-34;p11)
C45207	FUS-CREB3L2_Fusion_Protein_Expression	Fusion_Protein_Expression	FUS-CREB3L2 Fusion Protein Expression
C45208	FUS-CREB3L1_Fusion_Protein_Expression	Fusion_Protein_Expression	FUS-CREB3L1 Fusion Protein Expression
C45209	Poor_Collagen_Rosette_Formation	Collagen_Rosette_Formation	Poor Collagen Rosette Formation
C45210	Classical_Low_Grade_Fibromyxoid_Sarcoma	Low_Grade_Fibromyxoid_Sarcoma	Classical Low Grade Fibromyxoid Sarcoma	A fibromyxoid sarcoma that may have poorly formed collagen rosettes, but lacks prominent, well formed collagen rosettes.  The behavior of this subtype of fibromyxoid sarcoma is identical to low grade fibromyxoid sarcoma with giant collagen rosettes.
C45212	PDL2_Gene_Overexpression	Gene_Abnormality	PDCD1LG2 Gene Overexpression|PDL2 Gene Overexpression
C45213	Primary_Cutaneous_Diffuse_Large_B-Cell_Lymphoma_Other	Primary_Cutaneous_Diffuse_Large_B-Cell_Lymphoma	Primary Cutaneous Diffuse Large B-Cell Lymphoma, Other	A rare type of primary cutaneous diffuse large B-cell lymphoma that does not belong in the group of primary cutaneous diffuse large B-cell lymphomas, leg type, or the group of primary cutaneous follicle center lymphomas.  It includes morphologic variants of diffuse large B-cell lymphoma (e.g. intravascular large B-cell lymphoma, plasmablastic lymphoma, T-cell/histiocyte rich lymphoma) that can involve the skin as the primary anatomic site.  Such cases, unlike their nodal counterparts, usually have an excellent prognosis. -- 2005
C45214	Primary_Cutaneous_Intravascular_Large_B-Cell_Lymphoma	Intravascular_Large_B-Cell_Lymphoma|Primary_Cutaneous_Diffuse_Large_B-Cell_Lymphoma_Other	Primary Cutaneous Intravascular Large B-Cell Lymphoma
C45215	Primary_Cutaneous_T-Cell_Histiocyte_Rich_Lymphoma	Primary_Cutaneous_Diffuse_Large_B-Cell_Lymphoma_Other|T-Cell_Histiocyte_Rich_Lymphoma	Primary Cutaneous T-Cell/Histiocyte Rich Lymphoma
C45216	Primary_Cutaneous_Plasmablastic_Lymphoma	Plasmablastic_Lymphoma|Primary_Cutaneous_Diffuse_Large_B-Cell_Lymphoma_Other	Primary Cutaneous Plasmablastic Lymphoma
C45217	Regional_Implant	Metastatic_Lesion	Regional Implant	A tumor deposit found in a resected specimen in the fatty adjacent tissue and not contained within lymphoid tissue.
C45218	Columbia_River_Chinook	Chinook	Columbia River Chinook
C45219	Diffuse_Large_B-Cell_Lymphoma_by_Gene_Expression_Profile	Diffuse_Large_B-Cell_Lymphoma	Diffuse Large B-Cell Lymphoma by Gene Expression Profile
C45220	Northern_Cherokee	Cherokee	Northern Cherokee
C45221	Platinum_Eskimo	Yupik_Eskimo	Platinum Eskimo|Platinum
C45222	Deleware_Indian	American_Indian	Deleware Indian|Deleware
C45223	Sault_Ste_Marie_Chippewa	Chippewa	Sault Ste. Marie Chippewa
C45224	St_Croix_Chippewa	Chippewa	St. Croix Chippewa
C45225	St_George	Unangan_Aleut	St. George
C45226	St_Paul	Unangan_Aleut	St. Paul
C45227	St_Marys	Yupik_Eskimo	St. Mary's
C45228	St_Michael	Yupik_Eskimo	St. Michael
C45229	Yavapai	Yuman	Yavapai
C45230	Neoplasm_by_Obsolete_Classification	Neoplasm_by_Special_Category	Neoplasm by Obsolete Classification
C45231	Type_3_Diffuse_Large_B-Cell_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|Diffuse_Large_B-Cell_Lymphoma_by_Gene_Expression_Profile	Type 3 Diffuse Large B-Cell Lymphoma|Non-GCB/ABC DLBCL|Non-GCB/ABC Diffuse Large B-Cell Lymphoma|Type 3 DLBCL	A recently recognized biologic subset of diffuse large B-cell lymphomas (DLBCL) that do not overexpress the genes whose overexpression characterizes the germinal center B-cell-like and activated B-cell-like DLBCL.  Morphologically, these lymphomas are either immunoblastic or centroblastic.  Patients with this type of diffuse large B-cell lymphoma are reported to have a less favorable outcome, similar to those with an activated B-cell-like gene expression profile.
C45233	Respiratory_System_Finding	Finding_by_Site_or_System	Respiratory System Finding	Patient complaints (symptoms), physical/laboratory findings(signs) related to the respiratory system.
C45234	Wound_Infection	Infectious_Disorder	Wound Infection	Infection occurring in the wound.
C45235	Solid_Dosage_Form	Pharmaceutical_Dosage_Form	Solid Dosage Form|Solid Dose Form
C45236	Plasmacytoid_Dendritic_Cell_Precursor	Dendritic_Cell	Plasmacytoid Dendritic Cell Precursor	A cell found in peripheral blood, lymphoid tissue, and some inflamed tissue. It produces vast amounts of type I interferons especially in response to viruses, therefore playing an important role in antiviral immunity and triggers for adaptive immune responses.
C45238	Cutaneous_Precursor_Lymphoblastic_Leukemia_Lymphoma	Cutaneous_Hematopoietic_and_Lymphoid_Cell_Neoplasm|Cutaneous_Lymphoproliferative_Disorder|Malignant_Skin_Neoplasm|Precursor_Lymphoblastic_Leukemia_Lymphoma	Cutaneous Precursor Lymphoblastic Lymphoma/Leukemia
C45240	Cutaneous_Hematopoietic_and_Lymphoid_Cell_Neoplasm	Hematopoietic_Cell_Neoplasm|Skin_Neoplasm	Cutaneous Hematopoietic and Lymphoid Cell Neoplasm
C45241	Cutaneous_Precursor_B-Lymphoblastic_Leukemia_Lymphoma	Cutaneous_Precursor_Lymphoblastic_Leukemia_Lymphoma|Precursor_B_Lymphoblastic_Leukemia_Lymphoma	Cutaneous Precursor B-Lymphoblastic Lymphoma/Leukemia
C45242	Cutaneous_Precursor_T-Lymphoblastic_Leukemia_Lymphoma	Cutaneous_Precursor_Lymphoblastic_Leukemia_Lymphoma|Precursor_T_Lymphoblastic_Leukemia_Lymphoma	Cutaneous Precursor T-Lymphoblastic Lymphoma/Leukemia
C45244	Semisolid_Dosage_Form	Pharmaceutical_Dosage_Form	Semisolid Dosage Form|Semisolid Dose Form
C45245	Dosage_Form_By_Phase_of_Matter	Retired_Concepts	Dosage Form By Phase of Matter|Dosage Form By Phase
C45246	Dosage_Form_By_Route_Of_Administration	Pharmaceutical_Dosage_Form	Dosage Form By Route Of Administration
C45247	Mus_musculus	Mouse	Mus musculus|House Mouse	The common house mouse, often used as an experimental organism.
C45249	Cutaneous_Mature_B-Cell_Neoplasm	Cutaneous_Hematopoietic_and_Lymphoid_Cell_Neoplasm|Cutaneous_Lymphoproliferative_Disorder|Mature_B-Cell_Lymphocytic_Neoplasm	Cutaneous Mature B-Cell Neoplasm|Cutaneous Mature B-Cell Lymphocytic Neoplasm
C45250	Cutaneous_Mature_T-Cell_and_NK-Cell_Neoplasm	Cutaneous_Hematopoietic_and_Lymphoid_Cell_Neoplasm|Cutaneous_Lymphoproliferative_Disorder|Mature_T-Cell_and_NK-Cell_Neoplasm	Cutaneous Mature T-Cell and NK-Cell Neoplasm
C45252	European_Union	Geographic_Area	European Union|EU	A supranational organization of 25 countries across the European continent.
C45253	String_Value	Data_Type	String|String Value	An expression consisting of a linear sequence of symbols (characters or words or phrases).
C45254	Boolean_Value	Data_Type	Boolean|Boolean Value	The type of an expression with two possible values, "true" and "false". Also, a variable of Boolean type or a function with Boolean arguments or result. The most common Boolean functions are AND, OR and NOT. (Free On-Line Dictionary of Computing)
C45255	Integer	Number	Integer|Integer Value	A number with no fractional part.
C45256	Vitreous_Body_Disorder	Eye_Disorder	Vitreous Body Disorder
C45257	Accession	Clinical_or_Research_Activity	Accession	A process of increasing by addition (as to a collection or group).
C45258	Medical_Record	Record	Medical Record|Medical Report	A chronological written account of a patient's examination and treatment that includes the patient's medical history and complaints, the physician's physical findings, the results of diagnostic tests and procedures, and medications and therapeutic procedures. (dictionary.com)
C45259	Electronic_Medical_Record	Medical_Record	Electronic Medical Record|EMR	An automated, on-line medical record containing clinical and demographic information about a patient that is available to providers, ancillary service departments, pharmacies, and others involved in patient treatment or care. (http://www.agencyinfo.net/iv/medical/health-glossary.htm)
C45260	Surgical_Pathology_Report	Pathology_Report	Surgical Pathology Report	A pathology report based upon samples obtained by or during surgery.
C45261	Collection_Object	Conceptual_Entities	Item Collection|Collection|Collection Object	A group of items of the same type, gathered for display or study.
C45262	Collected_By	General_Modifier	Collected By	Indicates the person, group, or institution who performed the collection act.
C45263	Due	General_Modifier	Due	Expected or scheduled.
C45264	Cutaneous_Chronic_Lymphocytic_Leukemia	Chronic_Lymphocytic_Leukemia|Cutaneous_Mature_B-Cell_Neoplasm	Cutaneous Chronic Lymphocytic Leukemia
C45265	Received_By	General_Modifier	Received By	Indicates the person or authoritative body who has received something.
C45266	Cutaneous_Mantle_Cell_Lymphoma	Cutaneous_Mature_B-Cell_Neoplasm|Mantle_Cell_Lymphoma	Cutaneous Mantle Cell Lymphoma
C45267	Cutaneous_Lymphomatoid_Granulomatosis	Cutaneous_Mature_B-Cell_Neoplasm|Lymphomatoid_Granulomatosis	Cutaneous Lymphomatoid Granulomatosis
C45268	Cutaneous_Nasal_Type_Extranodal_NK_T-Cell_Lymphoma	Cutaneous_Mature_T-Cell_and_NK-Cell_Neoplasm|Nasal_Type_Extranodal_NK_T-Cell_Lymphoma	Cutaneous Nasal Type Extranodal NK/T-Cell Lymphoma
C45269	Audit	Clinical_or_Research_Activity	Audit	A methodical examination or review of a condition or situation.
C45270	Biospecimen_Distribution_Object	UML_Entity	Biospecimen Distribution Object|Biospecimen Distribution	A dimension table that lists the material distributed. This includes:  ITEM_TYPE, ITEM_ID, ITEM_QUANT, and ITEM QUANT_UNIT.  (caTISSUE)
C45271	Cutaneous_Angioimmunoblastic_T-Cell_Lymphoma	Angioimmunoblastic_T-Cell_Lymphoma|Cutaneous_Mature_T-Cell_and_NK-Cell_Neoplasm	Cutaneous Angioimmunoblastic T-Cell Lymphoma
C45272	Cutaneous_Adult_T-Cell_Lymphoma_Leukemia	Adult_T-Cell_Lymphoma_Leukemia|Cutaneous_Mature_T-Cell_and_NK-Cell_Neoplasm	Cutaneous Adult T-Cell Lymphoma/Leukemia
C45273	Distribution_Activity	Clinical_or_Research_Activity	Distribution|Distributed	The act of distributing or spreading or apportioning.
C45274	Distributed_By	General_Modifier	Distributed By	Indicates the person or authoritative body who has distributed something.
C45275	Tracking	Clinical_or_Research_Activity	Tracking	The act or process of following a person, animal, or object through space or time.
C45276	Kingdom_Taxon	Taxon	Kingdom	The highest taxonomic rank, immediately above phylum or division. There are five biological kingdoms (Monera, Protista, Plantae, Fungi, Animalia) into which organisms are grouped, based on common characteristics.
C45277	Phylum_Taxon	Taxon	Phylum	A major division of a biological kingdom, consisting of closely-related classes; represents a basic fundamental pattern of organization and, presumably, a common descent.
C45278	Subphylum_Taxon	Taxon	Subphylum	A taxonomic group ranking between a phylum and a class.
C45279	Log	Document_Type	Log|Event Log	A written record of events.
C45280	Class_Taxon	Taxon	Class	A collection of taxonomic subdivisions directly under Phylum. It is a major group of organisms, e.g. Mammalia, Reptilia, Gastropoda, Insecta, etc that contains a large number of different sublineages, but have shared characteristics in common (e.g. warm-blooded, fur, six legs etc).
C45281	Object	Conceptual_Entities	Object	Something perceptible by one or more of the senses, especially by vision or touch; a material thing. (dictionary.com)
C45282	Unique	General_Modifier	Unique	The single one of its kind.
C45284	Coordinator	Person	Coordinator	A person responsible for organizing multiple events or efforts into a smaller number of tasks.
C45285	Subclass_Taxon	Taxon	Subclass	A taxonomic subdivisions more specific than class but more general than order.
C45286	Infraclass_Taxon	Taxon	Infraclass	A taxonomic category of related organisms ranking below a subclass and above an order.
C45287	Order_Taxon	Taxon	Order	A taxonomic category between Class and Family.  It is group of organisms that although differing quite a bit among themselves still have a large degree of characteristics in common.
C45288	Suborder_Taxon	Taxon	Suborder	A taxonomic group that is a subdivision of an order.
C45289	Infraorder_Taxon	Taxon	Infraorder	A taxonomic category of related organisms ranking below a suborder and above a family.
C45290	Family_Taxon	Taxon	Family	A taxonomic category between Order and Genus. It consists of a group of organisms among which the differences are quite minor, e.g. Equiidae - horses and their relatives.
C45291	Subfamily_Taxon	Taxon	Subfamily	A taxonomic category below a family.
C45292	Genus_Taxon	Taxon	Genus	A taxonomic category ranking below a family (or Subfamily) and above a species and generally consisting of a group of species exhibiting similar characteristics.
C45293	Species_Taxon	Taxon	Species	A group of organisms that differ from all other groups of organisms and that are capable of breeding and producing fertile offspring.
C45294	Protocol_Requirement_Object	UML_Entity	Protocol Requirement Object|Protocol Requirement	A dimension table that lists the specimen requirements for this protocol. Specimen requirements include:  SPECIMEN_TYPE, SPECIMEN_QUANT, and DISEASE_STATUS. (caTISSUE)
C45295	CD4_Positive_Neoplastic_Cells_Present	Positive_Immunophenotypic_Test_Result	CD4-Positive Neoplastic Cells Present
C45296	CD56_Positive_Neoplastic_Cells_Present	Positive_Immunophenotypic_Test_Result	CD56-Positive Neoplastic Cells Present
C45297	Gel	Substance	Gel	Jelly like material formed by the coagulation of a colloidal liquid. (from On-line Medical Dictionary)
C45298	Liquid	Fluid	Liquid	A substance in the fluid state of matter having no fixed shape but a fixed volume.
C45299	Gas	Fluid	Gas	A fluid in the gaseous state having neither independent shape nor volume and being able to expand indefinitely.
C45300	Solid	Substance	Solid	The state in which a substance has no tendency to flow under moderate stress; resists forces (such as compression) that tend to deform it; and retains a definite size and shape.
C45301	Glass	Solid	Glass	A brittle transparent solid with irregular atomic structure.
C45302	Powder	Solid	Powder	A solid substance in the form of tiny loose particles; a solid that has been pulverized.
C45303	Mist	Substance	Mist	A suspension of fine drops of a liquid in a gas. (dictionary.com)
C45304	Suspension	Mixture	Suspension	A mixture in which fine particles are suspended in a fluid where they are supported by buoyancy.
C45305	Mixture	Substance	Suspension	A substance consisting of two or more substances mixed together (not in fixed proportions and not with chemical bonding).
C45306	Substance	Material	Substance	A material with particular features.
C45307	Electrophoresis_Gel	Diagnostic_Therapeutic_and_Research_Equipment	Electrophoresis Gel|Gel	A gel matrix through which molecules are separated, usually by size or charge, under the influence of an electrical field.
C45308	Agarose_Gel	Electrophoresis_Gel	Agarose Gel	An electrophoresis gel composed of agarose dissolved in an aqueous buffer.
C45309	Polyacrylamide_Gel	Electrophoresis_Gel	Polyacrylamide Gel	An electrophoresis gel composed of polyacrylamide in an aqueous buffer.
C45310	Neoplastic_Small_to_Medium-Sized_B-Lymphocyte_Resembling_a_Centrocyte	Neoplastic_B-Lymphocyte|Neoplastic_Small_to_Medium-Sized_Lymphocyte	Neoplastic Small to Medium-Sized B-Lymphocyte Resembling a Centrocyte
C45311	Lane	Conceptual_Entities	Lane	A defined path with physical dimensions through which an object or substance may traverse.
C45312	Segment	Part	Segment	One of the parts into which something naturally divides.
C45313	Part	Conceptual_Entities	Part	One of the portions into which something is regarded as divided and which together constitute a whole.
C45314	Reviewed	General_Modifier	Reviewed	Having been appraised, evaluated, or analyzed.
C45315	Neoplastic	Disease_Laboratory_Finding_Modifier	Neoplastic	Exhibiting characteristics of independently proliferating cells, notably altered morphology, growth characteristics, and/or biochemical and molecular properties.
C45317	Neoplastic_Follicle_Center_Cell	Neoplastic_B-Lymphocyte	Neoplastic Follicle Center B-Cell
C45318	Confluent_Sheets_of_Neoplastic_B-Lymphocytes_Present	Abnormal_Cells_Present	Confluent Sheets of Neoplastic B-Lymphocytes Present
C45319	Study_Object	UML_Entity	Study Object|Study	An abbreviated set of written procedures that describe how a previously collected biospecimen will be utilized.  Note that biospecimens may be collected (and utilized) with one PROTOCOL and then later utilized by multiple different STUDIES. (caTISSUE)
C45320	Study_Requirement_Object	UML_Entity	Study Requirement Object	A dimension table that lists the biospecimen requirements for this STUDY Biospecimen requirements include: .  (caTISSUE)
C45321	Dermal_Involvement	Integumentary_System_Finding	Dermal Involvement
C45322	Storage_Unit	Diagnostic_Therapeutic_and_Research_Equipment	Storage Unit|Storage Device|Unit	A physical structure or device capable of holding objects or samples.
C45324	CD8_Positive_Neoplastic_Cells_Present	Positive_Immunophenotypic_Test_Result	CD8-Positive Neoplastic Cells Present
C45325	Since	Temporal_Modifier	Since	Subsequent to; after.
C45327	Hydroa_Vacciniforme-Like_Cutaneous_T-Cell_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|Childhood_Mature_T-and_NK-Cell_Lymphoma|Cutaneous_T-Cell_Lymphoma|Epstein-Barr_Virus-Related_Non-Hodgkin_s_Lymphoma	Hydroa Vacciniforme-Like Cutaneous T-Cell Lymphoma	A rare, EBV-positive primary cutaneous T-cell lymphoma, composed of CD8 positive cytotoxic T-lymphocytes.  It is considered a variant of nasal type extranodal NK/T-cell lymphoma.  It affects children, almost exclusively in Latin America and Asia.  Patients present with papulovesicular skin lesions, clinically resembling hydroa vacciniforme, in areas of sun-exposed skin.  The prognosis is poor. -- 2005
C45328	Papulovesicular_Lesion	Integumentary_System_Signs_and_Symptoms|Lesion	Papulovesicular Lesion
C45329	Active	General_Modifier	Active	Taking part in an activity.
C45330	Added	General_Modifier	Added	Combined or joined to increase in size or quantity or scope.
C45331	Neoplastic_Immunoblast-Like_T-Lymphocyte	Neoplastic_T-Lymphocyte	Neoplastic Immunoblast-Like T-Lymphocyte
C45332	Unspecified_Primary_Cutaneous_Peripheral_T-Cell_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|Cutaneous_T-Cell_Lymphoma	Primary Cutaneous Peripheral T-Cell Lymphoma, Unspecified|Unspecified Primary Cutaneous Peripheral T-Cell Lymphoma	A primary cutaneous T-cell lymphoma that does not fit into any of the well defined groups of cutaneous T-cell lymphomas.  It usually affects adults.  Patients present with localized or generalized skin nodules or tumor masses.  Morphologically, there is a nodular or diffuse lymphocytic infiltrate, composed of medium-sized to large T-cells or immunoblast-like T-cells.  Neoplastic large T-lymphocytes represent at least 30% of the total cellular population.  The prognosis is poor.
C45333	Sequence_Similarity	Properties_or_Attributes	Sequence Similarity	The degree of similarity between the primary sequence of two biological macromolecules.
C45334	Rimming_of_Adipose_Tissue_Cells_Present	Morphologic_Finding	Rimming of Adipose Tissue Cells Present
C45335	RefSeq	Information_Resources	RefSeq|Reference Sequence Collection	The Reference Sequence (RefSeq) collection aims to provide a comprehensive, integrated, non-redundant set of sequences, including genomic DNA, transcript (RNA), and protein products, for major research organisms.  RefSeq standards serve as the basis for medical, functional, and diversity studies; they provide a stable reference for gene identification and characterization, mutation analysis, expression studies, polymorphism discovery, and comparative analyses. RefSeqs are used as a reagent for the functional annotation of some genome sequencing projects, including those of human and mouse. 
C45336	Producer	Person	Producer	A person or group that creates or manufactures something.
C45337	Copyright	Document_Type	Copyright	A document or statement granting exclusive right to own, publish, and sell literary, musical, or artistic work, or intellectual property.
C45338	Authoritative	General_Modifier	Authoritative	Sanctioned by established authority; having authority or ascendancy or influence; of recognized authority or excellence..
C45339	Primary_Cutaneous_Aggressive_Epidermotropic_CD8-Positive_T-Cell_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|Cutaneous_T-Cell_Lymphoma	Primary Cutaneous Aggressive Epidermotropic CD8-Positive T-Cell Lymphoma	An aggressive, epidermotropic primary cutaneous T-cell lymphoma.  It is characterized by the presence of eruptive papules and nodules, or tumors, which may be localized or disseminated.  Morphologically, it is composed of small to medium-sized, or medium-sized to large, CD8-positive T-lymphocytes with pleomorphic or blastic nuclei.  Epidermotropism is often pronounced.  Angiocentricity and angioinvasion may be present. -- 2005
C45340	Cutaneous_Gamma_Delta_T-Cell_Lymphoma	Aggressive_Non-Hodgkin_s_Lymphoma|Cutaneous_T-Cell_Lymphoma	Cutaneous Gamma/Delta T-Cell Lymphoma	An aggressive cutaneous lymphoma of mature, activated gamma/delta T-lymphocytes.  It usually presents with disseminated plaques and nodules.  Involvement of mucosal sites is frequent.  However, involvement of lymph nodes, spleen, or bone marrow is uncommon.  Morphologically, there are three patterns of cutaneous involvement: epidermotropic, dermal, and subcutaneous.  Often, more than one pattern may co-exist in a single biopsy specimen, or may be present in different biopsy specimens from the same patient.  The lymphocytic infiltrate is composed of medium- to large-sized lymphocytes expressing CD56.  Most cases lack both CD4 and CD8, although CD8 may be present in some cases.  This group of lymphomas includes cases previously known as subcutaneous panniculitis-like T-cell lymphoma with a gamma/delta phenotype.
C45341	Mature_Activated_Gamma_Delta_T-Lymphocyte	T_Gamma-Delta_Lymphocyte	Activated Mature Gamma/Delta T-Lymphocyte with a Cytotoxic Phenotype	A mature lymphocyte whose T cell receptor, a gamma polypeptide chain linked by a disulfide bridge to a delta polypeptide chain, has recognized specific foreign antigens and self MHC antigens.  This type of cell is most often found in the gut and epidermis.
C45366	Primary_Cutaneous_CD4-Positive_Small_Medium-Sized_Pleomorphic_T-Cell_Lymphoma	Cutaneous_T-Cell_Lymphoma|Indolent_Non-Hodgkin_s_Lymphoma	Primary Cutaneous CD4-Positive Small/Medium-Sized Pleomorphic T-Cell Lymphoma	A primary cutaneous T-cell lymphoma.  It usually presents with a solitary plaque or tumor on the face, neck, or upper trunk.  Morphologically, it is composed of small to medium-sized CD4-positive, CD8-negative, and CD30-negative pleomorphic T-lymphocytes.  A small number of large pleomorphic T-lymphocytes may also be present.  The lymphocytic infiltrate is dermal.  Focal epidermotropism and subcutaneous involvement may be present.  The prognosis is favorable.
C45367	Minor	General_Modifier	Minor	Lesser or smaller in amount, extent, or size.
C45368	Major	General_Modifier	Major	Greater or bigger in amount, extent, or size.
C45369	Single_Nucleotide_Polymorphism_Database	Information_Resources	Single Nucleotide Polymorphism Database|dbSNP	The Single Nucleotide Polymorphism database (dbSNP) is a database repository and internet resource for a broad collection of simple genetic polymorphisms.  It is hosted by the National Center for Biotechnology Information.
C45370	Disease_Ontology_Object	UML_Entity	Disease Ontology Object|Disease Ontology	Disease objects specify a disease name and ID; disease objects also provide access to: ontological relations to other diseases; clinical trial protocols treating the disease; and specific histologies associated with instances of the disease.
C45371	Disease_Ontology_Relationship	UML_Entity	Disease Ontology Relationship	The disease relationship specifies the relationship among diseases.
C45372	Eye_Infection	Infectious_Disorder_by_Site|Non-Neoplastic_Eye_Disorder	Eye Infection
C45373	Population_Frequency	Frequency	Population Frequency|Allele Frequency|Gene Frequency	A description of the relative rate of occurrence of specific alleles, traits, or other factors within a population of organisms.
C45374	Nucleotide_Sequence	Macromolecular_Structure	Nucleotide Sequence|Sequence	The sequence of nucleotide residues along an RNA or DNA chain.
C45377	Gene_Relative_Location_Object	UML_Entity	Gene Relative Location|Gene Relative Location Object|Location on Gene	The location of a feature (for example a SNP, repeat, etc.) relative to the coding sequence of a gene.
C45378	Technology_Platform	Diagnostic_Therapeutic_and_Research_Equipment	Technology Platform|Platform	The specific version (manufacturer, model, etc.) of a technology that is used to carry out a laboratory or computational experiment.
C45379	Multilocular_Thymic_Cyst	Thymic_Cyst	Multilocular Thymic Cyst
C45380	Thymic_Mucosa-Associated_Lymphoid_Tissue_Lymphoma	Extranodal_Marginal_Zone_B-Cell_Lymphoma_of_Mucosa-Associated_Lymphoid_Tissue|Thymic_Lymphoma	Thymic Mucosa-Associated Lymphoid Tissue Lymphoma
C45381	CD15-Positive_Neoplastic_Cells_Present	Positive_Immunophenotypic_Test_Result	CD15-Positive Neoplastic Cells Present
C45382	Cell_Strain	Specimen	Cell Strain	Cells adapted to culture, but with finite division potential. (On-line Medical Dictionary)
C45383	Carcinogenic_Metal	Inorganic_Carcinogen	Carcinogenic Metal	An electropositive element that can increase the risk of human cancer and is characterized by ductility, malleability, luster, the ability to conduct heat and electricity and the tendency to lose rather than gain electrons in chemicals. (NCI05)
C45384	Single_Nucleotide_Polymorphism_in_Intergenic_Sequences	Single_Nucleotide_Polymorphism	Intergenic SNP|Single Nucleotide Polymorphism in Intergenic Sequences	Single Nucleotide Polymorphism in Intergenic Sequences consists of a variation at an appreciable frequency between individuals of a single interbreeding population of a single nucleotide, due to base substitution, at an equivalent location within a DNA sequence of genetic material that lies between the boundaries of adjacent genes. SNPs occur, on average, once every 1000 bases and can be used in gene mapping and linkage analysis.
C45385	Carcinogenic_Mineral	Inorganic_Carcinogen	Carcinogenic Mineral	An inorganic, crystalline solid substance with a well-defined chemical composition and with characteristic physical properties that is found in nature and has the ability to increase human cancer risk. (NCI05)
C45386	Carcinogenic_Chlorinated_Hydrocarbon	Carcinogenic_Halogenated_Hydrocarbon	Carcinogenic Chlorinated Hydrocarbon	A hydrocarbon compound consisting of carbons with one or more chloride atom incorporated in its structure that can increase the risk of human cancer. (NCI05)
C45387	Single_Nucleotide_Polymorphism_in_Intronic_Sequences	Single_Nucleotide_Polymorphism	Intronic SNP|Intronic, Intron SNP|Single Nucleotide Polymorphism in Intronic Sequences	Single Nucleotide Polymorphism in Intronic Sequences (Intronic SNP) consists of a variation at an appreciable frequency between individuals of a single interbreeding population of a single nucleotide, due to base substitution, at an equivalent location within a transcribed non-coding intervening DNA sequence separating protein-coding sequences (exons) in an eukaryotic nuclear gene. Poorly conserved and of variable length and number, intron sequences are removed from nascent message RNA transcripts in the nucleus after the 5' cap and polyA tail have been added. Self-complementary sequences at exon-intron junctions form a hairpin structure recognized by enzymes that splice exons together into a mature mRNA that is ready for translation in the cytoplasm. When the intron is removed, the donor junction at the 5' end of the intron is spliced to the acceptor junction at the 3' end of the intron.
C45388	Carcinogenic_Brominated_Hydrocarbon	Carcinogenic_Halogenated_Hydrocarbon	Carcinogenic Brominated Hydrocarbon	A hydrocarbon compound consisting of carbons with one or more bromide atom incorporated in its structure that can increase the risk of human cancer. (NCI05)
C45389	Acceptor_Splice_Site_SNP	Splice_Site_SNP	Acceptor Splice Site SNP|Intronic, Acceptor Splice Site SNP	A heritable single nucleotide polymorphism located at the acceptor splice site in certain allelic variants of eukaryotic genes. These sites are located in genes at intron to exon junctions at the 3' end of the intron.
C45390	Donor_Splice_Site_SNP	Splice_Site_SNP	Donor Splice Site SNP|Intronic, Donor Splice Site SNP	An inherited single base change at a donor splice site in a genomic DNA sequence that results in an allelic variant of the wild-type gene. Donor splice sites are located at exon to intron junctions at the 5' end of the intron.
C45391	Carcinogenic_Fluorinated_Hydrocarbon	Carcinogenic_Halogenated_Hydrocarbon	Carcinogenic Fluorinated Hydrocarbon	A hydrocarbon compound consisting of carbons with one or more fluoride atom incorporated in its structure that can increase the risk of human cancer. (NCI05)
C45392	Single_Nucleotide_Polymorphism_in_UTR_Sequences	Single_Nucleotide_Polymorphism	Untranslated Region SNP|Single Nucleotide Polymorphism in UTR Sequences|UTR SNP	Single Nucleotide Polymorphism in UTR Sequences consists of a variation at an appreciable frequency between individuals of a single interbreeding population of a single nucleotide, due to base substitution, at an equivalent location within the sequence region at the 5' end (preceding the initiation codon) or at the 3' end (following the stop codon) of a messenger RNA that are not translated into protein and may contain transcription and translation regulating sequences.
C45393	_5_Untranslated_Region_SNP	Single_Nucleotide_Polymorphism_in_UTR_Sequences	5' Untranslated Region SNP|5' UTR SNP|UTR, 5' SNP	A 5' Untranslated Region SNP consists of a variation at an appreciable frequency between individuals of a single interbreeding population of a single nucleotide, due to base substitution, at an equivalent location within the sequence region at the 5' end of a messenger RNA (preceding the initiation codon) that is not translated into protein and may contain the ribosome binding site and other transcription and translation regulating sequences.
C45394	_3_Untranslated_Region_SNP	Single_Nucleotide_Polymorphism_in_UTR_Sequences	3' Untranslated Region SNP|3' UTR SNP|UTR, 3' SNP	A 3' Untranslated Region SNP consists of a variation at an appreciable frequency between individuals of a single interbreeding population of a single nucleotide, due to base substitution, at an equivalent location within the sequence region at the 3' end of a messenger RNA (following the stop codon) that is not translated into protein and may contain transcription and translation regulating sequences.
C45396	Synonymous_Coding_SNP	Single_Nucleotide_Polymorphisms_in_Coding_Sequences	Synonymous Coding SNP|Coding, Synonymous SNP	Synonymous Coding SNP consists of a variation at an appreciable frequency between individuals of a single interbreeding population of a single nucleotide, due to base substitution, at an equivalent location within a protein-coding region of a gene that causes no amino acid change in the protein product and no detectable phenotypic effect; a silent mutation.
C45397	Non-synonymous_Coding_SNP	Single_Nucleotide_Polymorphisms_in_Coding_Sequences	Non-synonymous Coding SNP|Coding, Non-synonymous SNP	A Non-synonymous Coding SNP consists of a variation at an appreciable frequency between individuals of a single interbreeding population of a single nucleotide, due to base substitution, at an equivalent location within a protein-coding region of a gene that causes an alteration of the translation of the affected codon into a different amino acid in the protein product. A missense non-synonymous SNP results in an amino acid change in the protein product due to a codon change, while a nonsense non-synonymous SNP results in a termination codon.
C45398	Carcinogenic_Nitrosamine	Nitroso_Carcinogen	Carcinogenic Nitrosamine	An organic N-nitroso compound with possible carcinogenic activity characterized by the group -NNO or -NHNO in its structure, formed by combining nitrates with amines. These compounds are found in various foods and many are carcinogenic or are suspected carcinogens. Cured meats can contain nitrosamines because meats contain amines and can react during cooking with sodium nitrite that is added as a preservative. (NCI05)
C45399	V-MLL_Fusion_Protein_Expression	Fusion_Protein_Expression	V-MLL Fusion Protein Expression
C45400	MOZ-V_Fusion_Protein_Expression	Fusion_Protein_Expression	MOZ-V Fusion Protein Expression
C45401	t_8_V_p11_v	Chromosomal_Translocation	t(8;V)(p11;v)
C45402	Carcinogenic_Cyclic_Nitrosamine	Carcinogenic_Nitrosamine	Carcinogenic Cyclic Nitrosamine	A ring compound that increases the risk of human cancer and is a N-nitroso derivative of secondary amines (R2N-NO), formed by combining nitrates with amines. (NCI05)
C45403	NOTCH1_Mutation	Gene_Abnormality	NOTCH1 Gene Mutation
C45404	_3_3-Dimethoxybenzidine_Containing_Dye	Carcinogen_Containing_Dye	3,3-Dimethoxybenzidine Containing Dye	A dye consisting of a diazotized dimethoxybenzidine nucleus that can have a wide variety of colors depending on the chemical groups attached at the diazo linkages. 3,3'-Dimethoxybenzidine containing dyes are mainly used to color textiles, leather, rubber and paper. All 3,3'-dimethoxybenzidine containing dyes are reasonably anticipated to be human carcinogens based on the fact that dimethoxybenzidine-based dyes are metabolized in vivo to form free 3,3'-dimethoxybenzidine. 3,3'-dimethoxybenzidine is possibly carcinogenic in humans. (NCI05)
C45405	_3_3-Dimethylbenzidine_Containing_Dye	Carcinogen_Containing_Dye	3,3-Dimethylbenzidine Containing Dye	A dye consisting of a diazotized dimethylbenzidine nucleus that can have a wide variety of colors depending on the chemical groups attached at the diazo linkages. 3,3'-Dimethylbenzidine containing dyes are mainly used to color textiles, as biological stains and are used in color photography. All 3,3'-dimethylbenzidine containing dyes are possible mutagens and are reasonably anticipated to be human carcinogens based on the fact that dimethylbenzidine-based dyes are metabolized in vivo to form free 3,3'-dimethylbenzidine. 3,3'-dimethylbenzidine is possibly carcinogenic in humans. (NCI05)
C45406	Benzidine_Containing_Dye	Carcinogen_Containing_Dye	Benzidine Containing Dye	A dye consisting of a diazotized benzidine nucleus that can have a wide variety of colors depending on the chemical groups attached at the diazo linkages. Benzidine based dyes are mainly used to color textiles, leather and paper but are also found in the rubber, plastic, soap, hair dye and petroleum industries. All benzidine containing dyes are considered human carcinogens based on the fact that they are metabolized in vivo to form free benzidine. (NCI05)
C45407	Electrical_Exposure	Finding_by_Cause	Electrical Exposure
C45408	Carcinogenic_Epoxide	Cyclic_Ether_Carcinogen	Carcinogenic Epoxide	A ring-shaped organic compound that can potentially cause cancer in humans and consists of an oxygen atom bonded to two other atoms, usually of carbon, that are already bonded to each other. (NCI05)
C45409	Carcinogenic_Salt	Inorganic_Carcinogen	Carcinogenic Salt	A chemical substance that can potentially cause cancer in humans and is produced from the reaction between acids and bases and consists of electropositive and electronegative radicals. (NCI05)
C45410	Chlorinated_Ring_Carcinogen	Halogenated_Ring_Carcinogen	Chlorinated Ring Carcinogen	A cancer causing cyclic compound in which one or more hydrogen atoms attached to the cyclic carbon atoms are substituted for chloride atoms. Many of which are pesticides. (NCI05)
C45411	Carcinogenic_Nitrosourea	Nitroso_Carcinogen	Carcinogenic Nitrosourea	Any of several chemically related nitrosourea-derivates that increases the risk of human cancer and are highly lipid-soluble and act by alkylation, carbamoylation, and inhibition of DNA repair. (NCI05)
C45412	Web_Services	Telecommunications	Web Services	Web services are software-powered resources or functional components whose capabilities can be accessed at an internet URI; automated resources accessed via the Internet. (from looselycoupled.com)
C45413	Dental_Liner_Dosage_Form	Solid_Dosage_Form	Dental Liner Dosage Form|Dental Liner Dose Form|LINER DENTAL|LINER, DENTAL	A material applied to the inside of the dental cavity, for protection or insulation of the surface.
C45414	Cement_Dosage_Form	Solid_Dosage_Form	Cement Dosage Form|CEMENT|Cement Dose Form	A substance that serves to produce solid union between two surfaces.
C45415	Culture_Dosage_Form	Pharmaceutical_Dosage_Form	Culture Dosage Form|CULTURE|Culture Dose Form	The propagation of microorganisms or of living tissue sells in special media conducive to their growth.
C45416	Graft_Dosage_Form	Pharmaceutical_Dosage_Form	Graft Dosage Form|GRAFT|Graft Dose Form|Graft Material Dosage Form	A slip of skin or of other tissue for implantation.
C45417	Encrypted	General_Modifier	Encrypted	Having been converted from text into code so as to be unintelligible to unauthorized parties.
C45418	Hierarchy	Terminology_Entity	Hierarchy|Tree	A series of ordered groupings of people or things within a system; an organization with one or a few things at the top and with several things below each other thing.
C45419	Biological_Process_Modifier	Qualifier	Biological Process Qualifier|Biological Process Modifier	A Biological Process Modifier is a term that helps define and render a biological process concept unique by further defining or describing a specific aspect of a biological process.
C45420	Biochemical_Activity_Level	Biological_Process_Modifier	Biochemical Activity Level	Biochemical Activity Level is a measurable amount of a specific function or role performed by a biological entity in a Biophysical Process, Biochemical Reaction, or Biochemical Process.
C45421	Enhanced_Activity	Biochemical_Activity_Level	Enhanced Activity	Enhanced Activity is a quantitative increase in a measurable amount of a specific function or role performed by a biological entity in a Biophysical Process, Biochemical Reaction, or Biochemical Process compared to the level of activity exhibited by that same biological entity in the majority of healthy individuals in a reference population.
C45422	Inactive_Activity	Biochemical_Activity_Level	Inactive	Inactive indicates an absence of a measurable amount of a specific function or role performed by a biological entity in a Biophysical Process, Biochemical Reaction, or Biochemical Process.
C45423	Reduced_Activity	Biochemical_Activity_Level	Decreased Activity|Reduced Activity	Decreased Activity is a quantitative reduction in a measurable amount of a specific function or role performed by a biological entity in a Biophysical Process, Biochemical Reaction, or Biochemical Process compared to the level of activity exhibited by that same biological entity in the majority of healthy individuals in a reference population.
C45424	Standard_Activity	Biochemical_Activity_Level	Standard Activity	Standard Activity is a measurable amount of a specific function or role performed by a biological entity in a Biophysical Process, Biochemical Reaction, or Biochemical Process that is similar to the level of activity exhibited by that same biological entity in the majority of healthy individuals in a reference population.
C45425	Latent_Celiac_Disease	Celiac_Disease	Latent Celiac Disease
C45426	Collagenous_Sprue	Celiac_Disease	Collagenous Sprue
C45427	Medical_Science	Occupation_or_Discipline	Medical Science	The science of dealing with the maintenance of health and the prevention and treatment of disease.
C45428	Tropical_Sprue	Malabsorption_Syndrome	Tropical Sprue|Post-Infective Tropical Malabsorption
C45429	Colon_Intramucosal_Adenocarcinoma	Colon_Adenocarcinoma	Colon Intramucosal Adenocarcinoma
C45430	Heart_Injury	Injury	Heart Injury
C45431	Low_Grade_Dysplasia_in_Ulcerative_Colitis	Dysplasia_in_Ulcerative_Colitis	Low Grade Dysplasia in Ulcerative Colitis
C45432	High_Grade_Dysplasia_in_Ulcerative_Colitis	Dysplasia_in_Ulcerative_Colitis	High Grade Dysplasia in Ulcerative Colitis
C45433	Dysplasia_in_Ulcerative_Colitis	Dysplasia	Dysplasia in Ulcerative Colitis
C45434	Primary_Focal_Segmental_Glomerulosclerosis	Focal_Segmental_Glomerulosclerosis	Primary Focal Segmental Glomerulosclerosis|Idiopathic Focal Segmental Glomerulosclerosis
C45435	Secondary_Focal_Segmental_Glomerulosclerosis	Focal_Segmental_Glomerulosclerosis	Secondary Focal Segmental Glomerulosclerosis
C45436	_9p24_2	Chromosome_Band	9p24.2	A chromosome band present on 9p
C45437	PDCD1LG2_Gene	Gene_with_Unknown_or_Unclassified_Function	PDCD1LG2 Gene|B7DC|BTDC|PD-L2|PDCD1L2|PDCD1LG2|PDL2|Programmed Cell Death 1 Ligand 2 Gene|bA574F11.2	Widely expressed (highest in placenta, heart, pancreas, lung, and liver), human PDCD1LG2 Gene encodes 273 aa 31-kDa Programmed Death Ligand 2 Protein, 70% identical to mouse Pdl2 protein and containing a signal sequence, IgV- and IgC-like domains, a transmembrane region, and a cytoplasmic region. Gamma-interferon stimulates PDCD1LG2 expression in monocytes. The IgV domain appears to bind to PDCD1, but not to CTLA4, CD28, or ICOS. Stimulation with anti-CD3 and Pdl2, or Pdl1, inhibits proliferation of mouse T cells and cytokine production. At low anti-CD3 concentrations, mouse Pdl2 preferentially co-stimulates CD4-positive (Th1) T-cell proliferation and Ifng production.
C45438	Programmed_Death_Ligand-2_Protein	Protein_with_Unknown_or_Unclassified_Function	Programmed Death Ligand 2 Protein|B7DC|Butyrophilin B7-DC|PD1 Ligand 2 Protein|PDCD1 Ligand 2 Protein|PDCD1L2|PDCD1LG2|PDL2|Programmed Cell Death 1 Ligand 2 Protein	Widely expressed (highest in placenta, heart, pancreas, lung, and liver) by human PDCD1LG2 Gene, 273 aa 31-kDa Programmed Death Ligand 2 Protein is 70% identical to mouse Pdl2 protein and contains a signal sequence, IgV- and IgC-like domains, a transmembrane region, and a cytoplasmic region. Gamma-interferon stimulates PDCD1LG2 expression in monocytes. The IgV domain appears to bind to PDCD1, but not to CTLA4, CD28, or ICOS. Stimulation with anti-CD3 and Pdl2, or Pdl1, inhibits proliferation of mouse T cells and cytokine production. At low anti-CD3 concentrations, mouse Pdl2 preferentially co-stimulates CD4-positive (Th1) T-cell proliferation and Ifng production.
C45439	t_2_19_p23_p13	Chromosomal_Translocation	t(2;19)(p23;p13)
C45440	t_2_17_p23_q35	Chromosomal_Translocation	t(2;17)(p23;q35)
C45441	t_2_22_p23_q11	Chromosomal_Translocation	t(2;22)(p23;q11)
C45442	TPM4-ALK_Fusion_Protein_Expression	Fusion_Protein_Expression	TPM4-ALK Fusion Protein Expression
C45443	ALO17-ALK_Fusion_Protein_Expression	Fusion_Protein_Expression	ALO17-ALK Fusion Protein Expression
C45444	MYH9-ALK_Fusion_Protein_Expression	Fusion_Protein_Expression	MYH9-ALK Fusion Protein Expression
C45445	Vaginal_Angiomyofibroblastoma	Benign_Vaginal_Neoplasm|Vaginal_Soft_Tissue_Neoplasm	Vaginal Angiomyofibroblastoma
C45446	Vulvar_Angiomyofibroblastoma	Benign_Vulvar_Neoplasm|Vulvar_Soft_Tissue_Neoplasm	Vulvar Angiomyofibroblastoma
C45447	Genotyping	Genetic_Techniques	Genotyping	The process of assessing genetic variation present in an individual.
C45448	t_X_2_q13_q35	Chromosomal_Translocation	t(X;2)(q13;q35)
C45449	t_2_2_q35_p23	Chromosomal_Translocation	t(2;2)(q35;p23)
C45450	PAX3-AFX_Fusion_Protein_Expression	Fusion_Protein_Expression	PAX3-AFX Fusion Protein Expression
C45451	PAX3-NCOA1_Fusion_Protein_Expression	Fusion_Protein_Expression	PAX3-NCOA1 Fusion Protein Expression
C45452	Allele_Associated_With_Disease_Role	NCI_Thesaurus_Role	Allele_Associated_With_Disease	This is a specializing role which may be used to override Gene_Associated_With_Disease that has been asserted for the gene class. The role is used to assert a link between the specific allele and disease and is considered to have clinical relevance. The domain and range kind for this role are Gene_Kind and Findings_and_Disorders_Kind, respectively.
C45453	Allele_Not_Associated_With_Disease_Role	NCI_Thesaurus_Role	Allele_Not_Associated_With_Disease	This is a specializing role which may be used to override Gene_Associated_With_Disease that has been asserted for the gene class. The role is used when the assertion on the gene class is not valid for the specific allele. The domain and range kind for this role are Gene_Kind and Findings_and_Disorders_Kind, respectively.
C45454	Allele_Has_Abnormality_Role	NCI_Thesaurus_Role	Allele_Has_Abnormality	This is a specializing role which may be used to override Gene_Has_Abnormality that has been asserted for the gene class. This role is used to establish a link between a specific allele and genetic or molecular abnormalities that have been observed in human cells and tissues associated with cancer or another disease of interest. The domain and range kind for this role are Gene_Kind and Molecular_Abnormality_Kind, respectively.
C45455	FUS-ERG_Fusion_Protein_Expression	Fusion_Protein_Expression	FUS-ERG Fusion Protein Expression
C45456	Allele_Not_Associated_With_Abnormality_Role	NCI_Thesaurus_Role	Allele_Not_Associated_With_Abnormality	This is a specializing role that overrides the inherited role Gene_Has_Abnormality, retained at the Gene Class.  This role is used to suppress Gene_Has_Abnormality inherited from Gene Class. It is used when the assertion on the gene class is not valid for the specific allele. The domain and range kind for this role are Gene_Kind and Molecular_Abnormality_Kind, respectively.
C45457	Allele_In_Chromosomal_Location_Role	NCI_Thesaurus_Role	Allele_In_Chromosomal_Location	This role is used for alleles whose location has changed from the wild-type gene chromosomal location. This role is used to assert a new location that differs from the wild-type gene chromosomal location. Chromosome number or chromosome arm specifies the location of allele and in such cases chromosome band becomes essentially meaningless. The domain and range kind for this role are Gene_Kind and Anatomy_Kind, respectively.
C45458	Allele_Absent_From_Wild-type_Chromosomal_Location_Role	NCI_Thesaurus_Role	Allele_Absent_From_Wild-type_Chromosomal_Location	This role is used for alleles whose location has changed from the wild-type gene chromosomal location. This role is used to negate a role relationship, inherited by a moved allele (e.g., translocation, inversion, etc.) that is asserted between the parent gene class and a chromosomal location. The domain and range kind for this role are Gene_Kind and Anatomy_Kind, respectively.
C45459	Allele_Ceases_Function_In_Pathway_Role	NCI_Thesaurus_Role	Allele_Ceases_Function_In _Pathway	This is a specializing role, which may be used to override (negate) the role Gene_is_Element_in_Pathway asserted at the gene class. This is used when an allele no longer functions in the specified pathway, due to a variation in the gene. The domain and range kind for this role are Gene_Kind and Pathway_Kind, respectively.
C45460	Allele_Plays_Altered_Role_in_Process_Role	NCI_Thesaurus_Role	Allele_Plays_Altered_Role_in_Process	This is a specializing role for alleles whose encoded products function differently (qualitatively or quantitatively) from the function asserted on their gene classes. It specializes the function of the wild type gene/gene product. The domain and range kind for this role are Gene_Kind and Biological_Process_Kind, respectively.
C45461	Allele_Has_Activity_Role	NCI_Thesaurus_Role	Allele_Has_Activity	This role asserts the observed level of activity associated with an allele in a given biological process, compared to the wild-type gene. The domain and range kind for this role are Gene_Kind and Properties_or_Attributes Kind, respectively.
C45462	Allele_Plays_Role_In_Metabolism_of_Chemical_or_Drug_Role	NCI_Thesaurus_Role	Allele_Plays_Role_In_Metabolism_of_Chemical_or_Drug	The role asserts a relationship between a specific allele (product; enzyme) and drug-metabolizing efficacy. The domain and range kind for this role are Gene_Kind and Chemicals_and_Drugs_Kind, respectively.
C45463	Allele_Is_Cancer_Related_Type_Role	NCI_Thesaurus_Role	Allele_Is_Cancer_Related_Type	The role asserts a relationship between a gene/allele and its cancer-related gene type (e.g. oncogene, tumor suppressor gene). The role is used to tag oncogenes/TSGs/etc. Both the domain and range kind for this role are Gene_Kind.
C45464	Relative_Enzyme_Activity_Property	NCI_Thesaurus_Property	Relative_Enzyme_Activity	Indicates drug efficacy of the allelic product.
C45465	SNP_ID_Property	NCI_Thesaurus_Property	SNP_ID	Indicates the dbSNP id number for the genetic polymorphism due to base substitutions.
C45466	SNP_Type_Property_Qualifier	NCI_Thesaurus_Property_Qualifier	SNP_Type	Indicates the location of the genetic polymorphisms in the gene region (e.g., Coding, UTR, Intronic)
C45467	TFG-NR4A3_Fusion_Protein_Expression	Fusion_Protein_Expression	TFG-NR4A3 Fusion Protein Expression|TFG-CHN Fusion Protein Expression
C45468	FDA_Table_Property	NCI_Thesaurus_Property	FDA_Table	Used to flag terms that are part of an FDA data standard manual, including Route of Administration, Dosage Form, Package Type and Potency.
C45469	t_3_9_q11-12_q22	Chromosomal_Translocation	t(3;9)(q11-12;q22)
C45470	t_X_20_p11_q13	Chromosomal_Translocation	t(X;20)(p11;q13)
C45471	SS18L1-SSX1_Fusion_Protein_Expression	Fusion_Protein_Expression	SS18L1-SSX1 Fusion Protein Expression
C45472	EWS-DDIT3_Fusion_Protein_Expression	Fusion_Protein_Expression	EWS-DDIT3 Fusion Protein Expression|EWS-CHOP Fusion Protein Expression
C45473	Intermediate_Locally_Aggressive_Blood_Vessel_Neoplasm	Intermediate_Blood_Vessel_Neoplasm	Intermediate (Locally Aggressive) Blood Vessel Neoplasm
C45474	Intermediate_Rarely_Metastasizing_Blood_Vessel_Neoplasm	Intermediate_Blood_Vessel_Neoplasm	Intermediate (Rarely Metastasizing) Blood Vessel Neoplasm
C45475	Composite_Hemangioendothelioma	Hemangioendothelioma|Intermediate_Rarely_Metastasizing_Blood_Vessel_Neoplasm	Composite Hemangioendothelioma
C45476	Polymorphus_Hemangioendothelioma	Hemangioendothelioma|Intermediate_Rarely_Metastasizing_Blood_Vessel_Neoplasm	Polymorphus Hemangioendothelioma
C45479	Reactive_Vascular_Proliferation	Non-Neoplastic_Vascular_Disorder	Reactive Vascular Proliferation
C45481	Vascular_Ectasia	Non-Neoplastic_Vascular_Disorder	Vascular Ectasia
C45483	Venous_Lake	Vascular_Ectasia	Venous Lake
C45485	Lymphangioma_Circumscriptum	Lymphangioma	Lymphangioma Circumscriptum
C45486	Butyrylcholinesterase	Esterase	Butyrylcholinesterase|Acylcholine Acylhydrolase|BCHE|Butyrylcholine Esterase|CHE1|Choline Esterase II|Cholinesterase|Plasma Cholinesterase|Pseudocholinesterase|Pseudocholinesterase E1	Human butyrylcholinesterase protein (602 aa, 68 kD), a serine esterase, is encoded by the human butyrylcholinesterase (BCHE) gene. This protein, a homotetramer, is present in most cells (except erythrocytes) and catalyzes the hydrolysis of acylcholines to yield a choline and a carboxylate anion. Reduced serum activity of the BCHE protein causes hypocholinesterasemia, a condition resulting in sensitivity to the muscle relaxant suxamethonium, which is commonly used in association with surgical anesthesia.
C45487	Cyclin-D2	Cyclin	Cyclin-D2|CCND2|G1/S-Specific Cyclin D2	Human G1/S-specific cyclin D2 protein (289 aa, 33 kD) is encoded by the human cyclin D2 (CCND2) gene. This protein is essential for control of the G1/S phase of the cell cycle. Cyclin D2 protein binds to the protein kinases CDK4 and CDK6 (which are also required for the G1/S transition) to form a serine/threonine kinase haloenzyme complex. Cyclin D2 protein both regulates these protein kinases and confers substrate specificity to this complex. It also interacts with the Rb tumor suppressor protein and plays a role in the phosphorylation of this protein. Cyclin D2 protein plays a role in the proliferation of gonadal cells and is associated with malignant transformation of these cells. High levels of this protein have been detected in both ovarian and testicular tumors.
C45488	CCAAT-Enhancer_Binding_Protein_Alpha	Transcription_Factor	CCAAT/Enhancer Binding Protein Alpha|CEBP|CEBP Alpha|CEBPA	Human CCAAT/enhancer binding protein alpha (358 aa, 38 kD) is encoded by the human CCAAT/enhancer binding protein (C/EBP), alpha (CEBPA) gene. This nuclear protein is a DNA-binding bZIP transcription factor that, as a homodimer, recognizes common motifs in both the promoter (CCAAT sequence) and enhancer (core homology sequence) regions of genes. CEBPA protein binds to the leptin gene promoter and modulates expression of the leptin protein, which is important in body weight homeostasis. CEBPA protein interacts with CDK2 and CDK4, thereby inhibiting kinase activity which results in cell growth arrest. This protein also plays an important role in the differentiation of immature granulocytes. Low levels of CEBPA protein has been associated with poor prognosis in acute myeloid leukemia patients.
C45489	MCF2_Gene	Signaling_Pathway_Gene	MCF2 Gene|DBL|MCF.2 Cell Line Derived Transforming Sequence Gene|MCF2	Human MCF.2 cell line derived transforming sequence (MCF2) gene, located at Xq27, undergoes alternative splicing to produce four alternative variants of the proto-oncogene DBL protein. Oncogenic activation of this gene occurs through rearrangement and loss of 5' sequences.
C45490	MCF2_p66_Protein	Guanine_Nucleotide_Exchange_Factor	MCF2 p66 Protein	Widely expressed by human MCF2 Gene as 4 alternative variants, 66-kDa MCF2 (DBL) p66 Protein is a cytoplasmic and membrane phosphoserine guanine nucleotide exchange factor that modulates the activity of small RHO GTPases by promoting conversion from GDP- to GTP-bound form. p66 contains a CRAL-TRIO domain, a DH domain, a PH domain and a spectrin repeat; the DH domain catalyzes GDP-GTP exchange. Each MCF2 variant displays distinct tissue distribution and unique specificities for modulating RHOA, RAC1 and CDC42.
C45491	Oncogene_MCF2	MCF2_Gene	Oncogene MCF2|DBL|MCF2	Human Oncogene MCF2 is a mutated variant of widely expressed MCF2 Gene, which encodes 4 alternative variants of 66-kDa MCF2 (DBL) p66 Protein, a cytoplasmic and membrane phosphoserine guanine nucleotide exchange factor that modulates the activity of small RHO GTPases by promoting conversion from GDP- to GTP-bound form. p66 contains a CRAL-TRIO domain, a DH domain, a PH domain and a spectrin repeat; the DH domain catalyzes GDP-GTP exchange. Five-prime recombinations of MCF2 delete N-terminal codons, producing activated oncogenic variant; the upstream replacing sequence, URS, is derived from D15S93 at 15q15-q23. Oncogene MCF2 disrupts normal cell function.
C45493	MCF2_Oncoprotein	MCF2_p66_Protein	MCF2 Oncoprotein|DBL|MCF2	Human MCF2 Oncoprotein is a product of a mutated variant (Oncogene MCF2) of widely expressed MCF2 Gene, which encodes 4 alternative variants of 66-kDa MCF2 (DBL) p66 Protein, a cytoplasmic and membrane phosphoserine guanine nucleotide exchange factor that modulates the activity of small RHO GTPases by promoting conversion from GDP- to GTP-bound form. p66 contains a CRAL-TRIO domain, a DH domain, a PH domain and a spectrin repeat; the DH domain catalyzes GDP-GTP exchange. Five-prime recombinations of MCF2 delete N-terminal codons, producing activated oncogenic variant; the upstream replacing sequence, URS, is derived from D15S93 at 15q15-q23. MCF2 Oncoprotein disrupts normal cell function.
C45494	Phenol_Compound	Organic_Chemical	Phenol Compound
C45495	Hydroquinone_Compound	Phenol_Compound	Hydroquinone Compound
C45496	Sulfur_Compound	Organic_Chemical	Organic Sulfur Compound
C45497	FES_Gene	Non-Receptor_Tyrosine_Kinase_Gene	FES Gene|FES|Feline Sarcoma Oncogene Gene	Human feline sarcoma oncogene (FES), located at 15q26.1, encodes the human homolog of a feline sarcoma retrovirus protein. The gene product produces twelve transcript variants encoding twelve distinct proteins. The FES gene is translocated in acute promyelocytic leukemia.
C45498	Tyrosine-Protein_Kinase_FES-FPS	Protein_Tyrosine_Kinase	Tyrosine-Protein Kinase FES/FPS|FES/FPS Protein Tyrosine Kinase|c-FES	Encoded by human FES Gene (FES/FPS Subfamily), 822 aa 93-kDa Tyrosine-Protein Kinase FES/FPS is a tyrosine-specific protein kinase involved in normal hematopoiesis and contains an FCH and SH2 domain.
C45499	Selenium_Compound	Inorganic_Chemical	Selenium Compound
C45500	Alkyne_Compound	Hydrocarbon	Alkyne Compound
C45501	Treatment_Status	Properties_or_Attributes	Treatment Status
C45502	Squamous_Cell_Lung_Carcinoma_Papillary_Variant	Non-Small_Cell_Lung_Carcinoma|Squamous_Cell_Lung_Carcinoma	Squamous Cell Lung Carcinoma, Papillary Variant	A morphologic variant of squamous cell lung carcinoma characterized by the presence of papillary structures. (NCI05)
C45503	Squamous_Cell_Lung_Carcinoma_Clear_Cell_Variant	Non-Small_Cell_Lung_Carcinoma|Squamous_Cell_Lung_Carcinoma	Squamous Cell Lung Carcinoma, Clear Cell Variant	A well differentiated morphologic variant of squamous cell lung carcinoma characterized by the presence of clear cells. (NCI05)
C45504	Squamous_Cell_Lung_Carcinoma_Small_Cell_Variant	Squamous_Cell_Lung_Carcinoma	Squamous Cell Lung Carcinoma, Small Cell Variant	A poorly differentiated morphologic variant of squamous cell lung carcinoma characterized by the presence of small tumor cells with focal squamous differentiation. (NCI05)
C45505	Oncogene_E1A	Viral_Oncogene	Oncogene E1A|E1A	Viral Oncogene E1A encodes E1A Protein, a regulator of early viral gene transcription. E1A interacts with diverse cellular proteins to override host cell controls of cell cycle, differentiation or apoptosis. E1A reprograms gene expression and other processes, which leads to transformation. E1A interacts with general and specific transcription factors, co-activators and chromatin-modifying enzymes. Targeted proteins include pRbs, p300/CBP, cyclin/Cdk, transcriptional corepressor CtBP, YY1, RACK1 and SWI/SNF complex, as well as cAMP/PKA signal components. E1A N-terminus binds pRb and p300/CBP regulators. E1A C-terminus negatively modulates the N-terminus and interacts with CtBP. By binding COUP-TF repressor and decreasing NF-kB Class I enhancer binding, E1A can repress MHC Class I gene transcription and allow tumor cells to avoid lysis by cytotoxic T lymphocytes. E1A also determines susceptibility to NK cell lysis.
C45506	Oncogene_E1B	Viral_Oncogene	Oncogene E1B|E1B	Viral Oncogene E1B encodes 55-kDa E1B Protein, a regulator of early and late viral gene expression. E1B is implicated in selective nuclear export of viral late mRNAs and inhibition of export of cellular mRNAs. E1B counters host cell defenses mediated by p53.
C45507	Squamous_Cell_Lung_Carcinoma_Basaloid_Variant	Non-Small_Cell_Lung_Carcinoma|Squamous_Cell_Lung_Carcinoma	Squamous Cell Lung Carcinoma, Basaloid Variant	A well differentiated morphologic variant of squamous cell lung carcinoma characterized by nuclear palisading. (NCI05)
C45508	Lung_Adenocarcinoma_Mixed_Subtype	Lung_Adenocarcinoma	Lung Adenocarcinoma, Mixed Subtype	A morphologic variant of lung adeoncarcinoma characterized by a predominant brochiolo-alveolar pattern and areas of invasive growth. (NCI05)
C45509	Fetal_Lung_Adenocarcinoma	Lung_Adenocarcinoma	Fetal Lung Adenocarcinoma|Pulmonary Adenocarcinoma of Fetal Type|Pulmonary Endodermal Tumor Resembling Fetal Lung	A very rare, well differentiated morphologic variant of lung adenocarcinoma characterized by the absence of morular structures and composed of glycogen-rich cells forming tubules that resemble fetal lung tubules. (NCI05)
C45511	Lung_Mucinous_Cystadenocarcinoma	Lung_Mucinous_Adenocarcinoma|Mucinous_Cystadenocarcinoma	Lung Mucinous Cystadenocarcinoma	A morphologic variant of lung mucinous adenocarcinoma characterized by the presence of a partially fibrous tissue capsule.  (NCI05)
C45512	Lung_Mucinous_Adenocarcinoma	Lung_Adenocarcinoma|Mucinous_Adenocarcinoma	Lung Mucinous Adenocarcinoma|Lung Colloid Adenocarcinoma	A circumscribed morphologic variant of lung adenocarcinoma characterized by the presence of mucin producing cells. (NCI05)
C45513	Verified	Properties_or_Attributes	Verified	Supported or established by evidence or proof.
C45514	Lung_Signet_Ring_Cell_Carcinoma	Lung_Adenocarcinoma|Signet_Ring_Cell_Carcinoma	Lung Signet Ring Cell Carcinoma	A morphologic variant of lung adenocarcinoma characterized by the presence of signet ring cells.  (NCI05)
C45515	Recombinant_Endostatin	Endothelial_Cell_Inhibitor|Matrix_Metalloproteinase_Inhibitor	Recombinant Endostatin|Endostatin|endostatin	A drug that is being studied for its ability to prevent the growth of new blood vessels into a solid tumor.  Endostatin belongs to the family of drugs called angiogenesis inhibitors.
C45516	Lung_Clear_Cell_Adenocarcinoma	Clear_Cell_Adenocarcinoma|Lung_Adenocarcinoma	Lung Clear Cell Adenocarcinoma	A well differentiated morphologic variant of lung adenocarcinoma characterized by the predominance of clear cells. (NCI05)
C45517	Chromosome_Object	Retired_Concepts	Chromosome Object	An object representing a specific chromosome for a specific taxon; provides access to all known genes contained in the chromosome and to the taxon.
C45518	Insert	Conceptual_Entities	Insert|Insertion	Something inserted or to be inserted.
C45519	Lymphoepithelioma-Like_Lung_Carcinoma	Large_Cell_Lung_Carcinoma|Lymphoepithelioma-Like_Carcinoma	Lymphoepithelioma-Like Lung Carcinoma	A morphologic variant of large cell lung carcinoma characterized by the presence of a syncytial growth pattern, large vesicular nuclei with esophnophilic nucleoi, and dense lymphocytic infiltration. (NCI05)
C45520	Gene_Object	Retired_Concepts	Gene Object|Gene	Gene objects are the effective portal to most of the genomic information provided by the caBIO data services; organs, diseases, chromosomes, pathways, sequence data, and expression experiments are among the many objects accessible via a gene. (caBIO)
C45521	Library_Object	Retired_Concepts	Library Object|Library	An object representing a CGAP library; provides access to information about: the tissue sample and its method of preparation, the library protocol that was used, the clones contained in the library, and the sequence information derived from the library.
C45523	Taxon_Object	Retired_Concepts	Taxon Object|Taxon	An object representing the various names (scientific, common, abbreviated, etc.) for a species associated with a specific instance of a Gene, Chromosome, Pathway, Protein, or Tissue.
C45524	Mitochondrial_Damage	Pathologic_Process	Mitochondrial Damage|Mitochondrial Toxicity	Mitochondrial Damage involves any process that leads to dysfunction of mitochondria, whether by oxidative damage, mutation of mitochondrial DNA or other by means.
C45525	Valvular_Heart_Disorder	Non-Neoplastic_Heart_Disorder	Valvular Heart Disorder
C45526	Actinolite_Asbestos	Asbestos	Actinolite Asbestos	A naturally occurring, bright green, fibrous amphibole asbestos mineral found in metamorphic rocks and as a contaminant in amosite asbestos. Chronic inhalation of its dust may cause asbestosis and increases the risk of respiratory tract cancer, mesothelioma and other lung cancers. Actinolite asbestos is a known human carcinogen. (NCI05)
C45527	Amosite_Asbestos	Asbestos	Amosite Asbestos	A naturally occurring, fibrous amphibole asbestos mineral with a color ranging from gray to greenish-brown. Amosite is used extensively in industry for various purposes. Chronic inhalation of its dust may cause asbestosis and increases the risk of respiratory tract cancer, mesothelioma and other lung cancers. Amosite asbestos is a known human carcinogen. (NCI05)
C45528	Anthophyllite_Asbestos	Asbestos	Anthophyllite Asbestos	A naturally occurring, rare, fibrous amphibole asbestos mineral with a color ranging from grayish-white to green. Chronic inhalation of its dust may cause asbestosis and increases the risk of respiratory tract cancer, mesothelioma and other lung cancers. Anthophyllite asbestos is a known human carcinogen. (NCI05)
C45529	Chrysotile_Asbestos	Asbestos	Chrysotile Asbestos|Chrysotile|White Asbestos	A naturally occurring, fibrous and silky, serpentine asbestos mineral with a color ranging from gray-white to yellow-green and is the most abundant and widely-used form of asbestos. Chrysotile is widely used in industry for various purposes. Chronic inhalation of its dust may cause asbestosis and increases the risk of digestive tract cancer, laryngeal cancer, mesothelioma and other lung cancers. Chrysotile asbestos is a known human carcinogen. (NCI05)
C45530	Tremolite_Asbestos	Asbestos	Tremolite Asbestos	A naturally occurring, grayish, fibrous amphibole asbestos mineral and occurs as a contaminant in chrysotile asbestos. Chronic inhalation of its dust may cause asbestosis and increases the risk of respiratory tract cancer, mesothelioma and other lung cancers. Tremolite Asbestos is a known human carcinogen. (NCI05)
C45531	Direct_Black_38	Benzidine_Containing_Dye	Direct Black 38|4-Amino-3-[[4'-((2,4-Diaminophenyl)azo)(1,1'-Biphenyl)-4-yl]azo]-5-Hydroxy-6-(Phenylazo)- 2,7-Naphthalenedisulfonic Acid, Disodium Salt|CI 30235|CI Direct Black 38	A Benzidine-based azo dye that is metabolized to free Benzidine in vivo. Direct black 38 is primarily used for the dyeing of textiles, leather and paper. Benzidine and its metabolic derivatives have been detected in the urine of workers exposed to Benzidine-based dyes. Exposure to this dye is strongly associated with the occurrence of bladder cancer. (NCI05)
C45532	Direct_Blue_6	Benzidine_Containing_Dye	Direct Blue 6|3,3'-[(1,1'-Biphenyl)-4,4'-Diylbis(Azo)]Bis(5-Amino-4-Hydroxy)- 2,7-Naphthalenedisulfonic Acid, Tetrasodium Salt|CI 22610|CI Direct Blue 6|Diphenyl-4,4'-Bis-Azo-2"-8"-Amino-1"-Naphthol-3",6"-Disulphonatesodium	A Benzidine-based azo dye that is metabolized to free Benzidine in vivo. Direct blue 6 is primarily used for the dyeing of textiles, leather and paper. Benzidine and its metabolic derivatives have been detected in the urine of workers exposed to Benzidine-based dyes.  Exposure to this dye is strongly associated with the occurrence of bladder cancer. (NCI05)
C45533	ASCII	Code	ASCII	The worldwide standard for the code numbers used by computers to represent all the uppercase and lowercase Latin letters, numbers, punctuation, and other symbols. There are 128 standard ASCII codes, each of which can be represented by a 7 digit binary number: 0000000 through 1111111.
C45534	Direct_Brown_95	Benzidine_Containing_Dye	Direct Brown 95|CI 30145|CI Direct Brown 95|Dihydrogen(5-[(4'-((2,6-Dihydroxy-3-((2-Hydroxy-5-Sulphophenyl)azo)Phenyl)azo)-4- Biphenylazo]Salicylato(2-))-Copper, Disodium Salt	A Benzidine-based azo dye that is metabolized to free Benzidine in vivo. Direct brown 95 is primarily used for the dyeing of textiles, leather and paper. Benzidine and its metabolic derivatives have been detected in the urine of workers exposed to direct Benzidine-based dyes and exposure is strongly associated with the occurrence of bladder cancer. (NCI05)
C45535	Is_Reference_Sequence	Retired_Concepts	Is Reference Sequence	Whether the sequence is a reference sequence.
C45536	Is_Preferred	Retired_Concepts	Is Preferred	Boolean value indicating if this is the preferred taxon.
C45537	Respirable_Quartz	Respirable_Crystalline_Silica	Respirable Quartz	A widespread, naturally occurring, crystalline metal oxide, and is a component in most rocks. Respirable quartz is found in metal and nonmetal mining and milling operations as well as in industries of foundry, granite, ceramic and stone. Inhalation exposure to respirable quartz causes chronic silicosis, emphysema, lymph node fibrosis and is associated with an increased risk of developing lung cancer. (NCI05)
C45538	Respirable_Cristobalite	Respirable_Crystalline_Silica	Respirable Cristobalite	A naturally occurring, crystalline metal found in volcanic rocks. Heating of silica generates respirable cristobalite, which is primarily found in refractory silica bricks. Inhalation exposure to respirable cristobalite causes chronic silicosis, emphysema, lymph node fibrosis and is associated with an increased risk of developing lung cancer. (NCI05)
C45539	Respirable_Tridymite	Respirable_Crystalline_Silica	Respirable Tridymite	A naturally occurring, crystalline metal oxide. Respirable tridymite is mainly found in volcanic rocks. Inhalation exposure to respirable tridymite causes chronic silicosis, emphysema, lymph node fibrosis and is associated with an increased risk of developing lung cancer. (NCI05)
C45540	Lung_Sarcomatoid_Carcinoma	Non-Small_Cell_Lung_Carcinoma|Sarcomatoid_Carcinoma	Lung Sarcomatoid Carcinoma	A rare, aggressive, poorly differentiated, non-small cell lung carcinoma characterized by the presence of a sarcomatoid component often associated with giant cell differentiation. There is a male to female ratio of 4:1.  Clinical symptoms include cough, hemoptysis, chest pain, progressive dyspnea and fever secondary to recurrent pneumonia. Cigarette smoking is a major risk factor. (NCI05)
C45541	Lung_Spindle_Cell_Carcinoma	Lung_Sarcomatoid_Carcinoma	Lung Spindle Cell Carcinoma	A rare, aggressive, poorly differentiated morphologic variant of sarcomatoid carcinoma characterized by the presence of malignant spindle cells with irregular nucleoli and nuclear hyperchromasia. (NCI05)
C45542	Lung_Pleomorphic_Carcinoma	Lung_Sarcomatoid_Carcinoma|Pleomorphic_Carcinoma	Lung Pleomorphic Carcinoma	A rare, aggressive, poorly differentiated morphologic variant of sarcomatoid carcinoma characterized by the presence of malignant glandular or squamous cells associated with malignant giant and/or spindle cells. (NCI05)
C45543	Lung_Carcinosarcoma	Carcinosarcoma|Lung_Sarcomatoid_Carcinoma	Lung Carcinosarcoma	A rare, aggressive, morphologic variant of lung sarcomatoid carcinoma composed of a mixture of non-small cell lung carcinoma and a sarcomatous component. (NCI05)
C45544	Lung_Mucoepidermoid_Carcinoma	Lung_Carcinoma|Mucoepidermoid_Carcinoma	Lung Mucoepidermoid Carcinoma	A lung carcinoma characterized by the presence of malignant non-keratinizing squamoid cells, mucin-producing cells and intermediate type cells. (NCI05)
C45545	Lung_Epithelial-Myoepithelial_Carcinoma	Epithelial-Myoepithelial_Carcinoma|Lung_Carcinoma	Lung Epithelial-Myoepithelial Carcinoma	A lung carcinoma usually arising within the bronchi or bronchial tubes characterized by the presence of myoepithelial cells, spindle cells, clear cells, and duct-forming epithelial cells.  Surgical resection may be curative. (NCI05)
C45546	Retinoic_Acid_Receptor_Activation	Receptor_Activation	Retinoic Acid Receptor Activation	Retinoic acid receptor activation is induced by specific ligand binding, resulting in transcriptional modulation. The mechanism of activation entails four steps necessary to achieve biological activity. These steps are as follows: 1) high-affinity binding of the retinoic acid signaling ligand to specific soluble cytoplasmic target carrier proteins at or near the cell membrane; 2) transport to the nucleus; 3) selective binding to DNA response elements in target genes; and 4) enhanced transcriptional activity of specific target genes.
C45547	Cytokine_Receptor_Activation	Receptor_Activation	Cytokine Receptor Activation	Cytokine receptor activation involves high-affinity binding of a cytokine-signaling ligand to specific cell surface target receptor proteins. Upon binding, conformational and functional changes take place in the receptor protein. Altered interaction of the ligand-bound receptor induces changes in cellular physiology through modification of the activity of one or more signal transduction pathways.
C45548	Antigen_Sensitization	Immune_Response	Antigen Sensitization	Antigen Sensitization is a process of immunization with an antigen preparation that renders an immune-response involving generation of antibodies against the specific antigen(s) injected.
C45549	Receptor_Desensitization	Biochemical_Process	Receptor Desensitization	Receptor Desensitization involves a reduction of receptor or cellular responsiveness to a continued or increased presence of ligand. Desensitization often involves inhibition of receptor activity or a reduction in the pool of available receptors, which alters the activity of associated signal transduction pathways and cellular physiology.
C45550	Lung_Typical_Carcinoid_Tumor	Low_Grade_Lung_Neuroendocrine_Neoplasm|Lung_Carcinoid_Tumor	Lung Typical Carcinoid Tumor
C45551	Lung_Atypical_Carcinoid_Tumor	Intermediate_Grade_Lung_Neuroendocrine_Neoplasm|Lung_Carcinoid_Tumor	Lung Atypical Carcinoid Tumor
C45552	Microtubule_Dynamic_Alteration	Microtubule_Alteration	Microtubule Dynamics Alteration	Microtubule structures are disassembled and re-assembled during mitosis to achieve the final state of cell division.  Microtubule dynamic alteration involves an interruption of the microtubule assembly and disassembly dynamics during cell cycle via exogenous agents.
C45553	Inhibition_Of_Amyloidogenesis	Biochemical_Process	Inhibition of Amyloidogenesis	Inhibition of Amyloidogenesis is a process that prevents the formation or growth of amyloid structures.
C45554	Ribosomal_Function_Inhibition	Biochemical_Process	Ribosomal Function Inhibition	Ribosomal Function Inhibition is a process that prevents normal translation, typically by interfering with ribosomal protein subunits or RNA components.
C45555	ABC_Transporter_Inhibition	Protein_Inhibition	ABC Transporter Inhibition	ABC Transporter Inhibition involves interference with, or restraint of, the activities of cell membrane glycoproteins selectively permeable to P-glycoprotein substrates.
C45556	Nucleoside_Analogue_Incorporation	Biochemical_Reaction	Nucleoside Analogue Incorporation|Incorporation of Nucleoside Analogue	Nucleoside Analogue Incorporation involves assimilation of nucleoside or nucleotide analogues into DNA or RNA.
C45557	Arsenic_Compound	Inorganic_Carcinogen	Arsenic Compound	A white, odorless, inorganic substance that contains the semi-metallic element arsenic usually in the 3 and 5-valence state, and emits toxic arsenic fumes when heated to decomposition. Arsenic compounds are primarily used in wood preservation. Exposure to this substance irritates skin and mucous membranes, and can affect the gastrointestinal tract, CNS, cardiovascular system, liver, kidneys and blood. Arsenic compounds are known human carcinogens and are associated with an increased risk of developing lung, skin, bladder, kidney, liver, prostate, digestive tract and colon cancer as well as cancer of the lymphatic and hematopoietic system. (NCI05)
C45558	Beryllium_Compound	Carcinogenic_Metal	Beryllium Compound	An inorganic substance that contains the metallic element beryllium with excellent thermal and electrical conductivity and is corrosion resistant. Beryllium compounds are used in the electronics, automotive, aerospace, defense and nuclear industries. Inhalation exposure to beryllium compounds can cause pneumonitis, and prolonged exposure can result in berylliosis, characterized by occurrence of granulomatous fibrosis in the lungs. Beryllium compounds are known human carcinogens and are associated with an increased risk of developing lung cancer. (NCI05)
C45559	Term_Word	Terminology_Entity	Term	A word or expression used for some particular thing.
C45560	Enhanced_Symbol	UML_Entity	Enhanced Symbol	This is a modification to the original GO database.  For many UniProt records, this field is the gene symbol for the specified gene_product.  For all other cases, it is the same as the symbol field. (GoMiner)
C45561	Label_Generic_Concept	Pharmaceutical_Product_Information	Label	A brief description given for purposes of identification; an identifying or descriptive marker that is attached to an object.
C45562	Phosphoribosyl_Pyrophosphate_Amidotransferase	Glycosyltransferase	Phosphoribosyl Pyrophosphate Amidotransferase|Amidophosphoribosyltransferase|EC 2.4.2.14|Glutamine PRPP Amidotransferase|Glutamine Phosphoribosylpyrophosphatate Amidotransferase|PPAT|Phosphoribosyldiphosphate 5-amidotransferase	The protein encoded by this gene is a member of the purine/pyrimidine phosphoribosyltransferase family. This protein is a regulatory allosteric enzyme that catalyzes the first step of de novo purine nucleotide biosynthesis. This gene and PAICS/AIRC, a bifunctional enzyme catalyzing steps six and seven in the purine nucleotide biosynthesis pathway, are located in close proximity on chromosome 4. (from Gene)
C45563	PPAT_Gene	Glycosyltransferase_Gene	PPAT Gene|ATASE|GPAT|Inorganic Pyrophosphatase 2 Gene|PPAT|Phosphoribosyl Pyrophosphate Amidotransferase Gene	This gene is a member of the purine/pyrimidine phosphoribosyltransferase family, encoding phosphoribosyl pyrophosphate amidotransferase that catalyzes the first step of de novo purine nucleotide biosynthesis. This gene was mapped to 4q12. (from Gene)
C45564	Amine	Organic_Chemical	Amine
C45565	Organoselenium_Compound	Organic_Chemical	Organoselenium Compound
C45566	Gain_of_Chromosome_3q24-qter	Chromosomal_Gain	Gain of Chromosome 3q24-qter
C45567	Low_Grade_Lung_Neuroendocrine_Neoplasm	Lung_Neuroendocrine_Neoplasm	Low Grade Lung Neuroendocrine Neoplasm
C45568	Intermediate_Grade_Lung_Neuroendocrine_Neoplasm	Lung_Neuroendocrine_Neoplasm	Intermediate Grade Lung Neuroendocrine Neoplasm
C45569	High_Grade_Lung_Neuroendocrine_Neoplasm	Lung_Neuroendocrine_Neoplasm	High Grade Lung Neuroendocrine Neoplasm
C45572	Pulmonary_Neuroendocrine_Cell	Neuroendocrine_Cell	Pulmonary Neuroendocrine Cell
C45573	Lung_Squamous_Papilloma	Respiratory_Papilloma|Squamous_Cell_Papilloma	Lung Squamous Papilloma|Lung Squamous Cell Papilloma
C45574	Splice_Site_SNP	Single_Nucleotide_Polymorphism_in_Intronic_Sequences	Splice Site SNP	An inherited single base substitution in a sequence of eukaryotic DNA located in either an acceptor (3' or downstream) or donor (5' or upstream) splice site of a gene. Functional single nucleotide polymorphisms in these intron-exon junctions can cause incorrect RNA splicing which, in turn, alters gene expression.
C45575	Upstream_Region_SNP	Single_Nucleotide_Polymorphism	Upstream Region SNP	An inherited single base substitution in a sequence of eukaryotic DNA located within a region 5' to the transcription start site of a gene. This type of single nucleotide polymorphism may affect gene expression if it occurs in the promoter region of a gene and alters the recognition sequence of a specific promoter protein.
C45576	Mutation_Abnormality	Molecular_Genetic_Abnormality	Mutation Abnormality|Mutation	A general term referring to single or multiple alterations in the genetic material of an organism that ranges from a single base change in a gene to the loss or addition of complete chromosomes. A mutation abnormality may be heritable or occur somatically.
C45577	Deletion_Abnormality	Mutation_Abnormality	Deletion Abnormality|Deletion	Loss of a genomic DNA sequence. The extent of a deletion ranges from the loss of a single nucleotide to the loss of a substantial portion of an entire chromosome. Thus, deletions may alter the function of a single gene or multiple genes.
C45578	Dominant-Negative_Mutation_Abnormality	Mutation_Abnormality	Dominant-Negative Mutation Abnormality|Dominant-Negative Mutation	An alteration in a DNA sequence from a eukaryotic or a prokaryotic organism that results in the expression of a variant gene product that inhibits the function of the related wild-type gene product in heterozygotes. This type of abnormality is typically heritable, although it can also occur somatically.
C45579	Embryonic_Lethal_Mutation_Abnormality	Mutation_Abnormality	Embryonic Lethal Mutation Abnormality|Embryonic Lethal Mutation	A heritable or somatic mutation in a genomic DNA sequence that causes the death of a eukaryotic organism at the embryonic stage of development. Embryonic lethal mutants result in phenotypes that do not allow life to be sustained.
C45580	Frameshift_Mutation_Abnormality	Mutation_Abnormality	Frameshift Mutation Abnormality|Frameshift|Frameshift Mutation	Insertion or deletion of one, two or four nucleotides that alters the correct reading frame of an amino acid-coding DNA sequence, resulting in an amino acid sequence that is changed or truncated. Frame shift mutations typically result in a mutated protein product that is inactive. This type of mutation abnormality can be either inherited or somatic.
C45581	Gene_Amplification_Abnormality	Gene_Abnormality	Gene Amplification Abnormality|Amplification|Gene Amplification	An increase in the copy number of a particular gene. This type of abnormality can be either inherited or somatic.
C45582	Gene_Duplication_Abnormality	Gene_Amplification_Abnormality	Gene Duplication Abnormality|Duplication|Gene Duplication	Generation of an extra copy of a particular gene in the genome. A gene duplication abnormality may occur by gene amplification, random breakage and reunion, retrotransposition or unequal crossing-over at meiosis. A gene duplication abnormality can be either heritable or somatic.
C45583	Gene_Deletion_Abnormality	Gene_Abnormality	Gene Deletion Abnormality|Deletion|Gene Deletion	Loss of a DNA sequence that contains one or more genes. This typically occurs via rearrangement, whereby DNA sequences that are normally separated become joined together. A gene deletion abnormality can be either heritable or somatic.
C45584	Gene_Fusion_Abnormality	Gene_Abnormality	Gene Fusion Abnormality|Gene Fusion	Fusion of two genes or segments of genes that were previously separated prior to a mutation abnormality such as translocation. A gene fusion abnormality results in the formation of a new genetic unit that typically exhibits altered functional characteristics. This type of mutation abnormality can be either heritable or occur somatically.
C45585	Missense_Mutation_Abnormality	Mutation_Abnormality	Missense Mutation Abnormality|Missense Mutation	A point mutation in a coding DNA sequence that causes a base change which results in an amino acid change in the protein product. This alteration may affect the stability and/or activity of the protein. A missense mutation abnormality may be heritable or occur spontaneously.
C45586	Splice-Site_Mutation_Abnormality	Mutation_Abnormality	Splice-Site Mutation Abnormality|Splice-Site Mutation	An aberrant DNA sequence that results from a mutation in a sequence of eukaryotic DNA located in either an acceptor (3' or downstream) or donor (5' or upstream) splice site of a gene. Functional mutations in these intron-exon junctions cause incorrect RNA splicing, resulting in altered gene expression. Splice-site mutations may be heritable or occur somatically.
C45587	Germline_Mutation_Abnormality	Mutation_Abnormality	Germline Mutation Abnormality|Germline Mutation	A mutation in the genomic DNA of reproductive cells (egg or sperm) that is retained during meiosis, mitosis, and cell differentiation. Ultimately, the mutation is present in every cell in the body of the offspring.
C45588	Insertion_Mutation_Abnormality	Mutation_Abnormality	Insertion Mutation Abnormality|Insertion|Insertion Mutation	Insertion of one or more nucleotides into a DNA sequence. An insertion mutation abnormality can result in a frame shift abnormality if the length of the inserted nucleotide strand is not divisible by three. This type of mutation abnormality can be either heritable or occur somatically.
C45589	Inversion_Mutation_Abnormality	Mutation_Abnormality	Inversion Mutation Abnormality|Inversion|Inversion Mutation	A structural change in genomic DNA where the 5' to 3' order of a nucleotide sequence is completely reversed to the 3' to 5' order relative to its adjacent sequences. This inversion is termed either pericentric, if it includes the centromere of a chromosome, or pancentric, if it excludes the centromere. An inversion mutation abnormality may be heritable or occur somatically.
C45590	Nucleotide_Transition_Abnormality	Mutation_Abnormality	Nucleotide Transition Abnormality|Transition|Transition Mutation	A point mutation that involves the substitution of a pyrimidine base for a different pyrimidine base or substitution of a purine base for a different purine base. Nucleotide transitions do not change the purine-pyrimidine orientation of a DNA sequence. A nucleotide transition abnormality may be heritable or occur somatically.
C45591	Nucleotide_Transversion_Abnormality	Mutation_Abnormality	Nucleotide Transversion Abnormality|Transversion|Transversion Mutation	A point mutation that involves the substitution of a pyrimidine base for a purine base or substitution of a purine base for a pyrimidine base. Nucleotide transversions change the purine-pyrimidine orientation of a DNA sequence. A nucleotide transversion abnormality may be heritable or occur somatically.
C45592	Somatic_Mutation_Abnormality	Mutation_Abnormality	Somatic Mutation Abnormality|Somatic Mutation	A mutation in a somatic cell. All eukaryotic cells, with the exception of germ cells (egg and sperm), are classified as somatic cells. A somatic mutation may affect the phenotype of the cell in which it occurs. However, the mutation will not be transmitted to offspring. These alterations are postulated to contribute to the development of cancer and other diseases.
C45593	UV_Mutation_Abnormality	Mutation_Abnormality	UV Mutation Abnormality|UV-Mutagenesis	A UV Mutation Abnormality is an altered heritable state of the genetic DNA nucleotide sequence caused by exposure to ultraviolet light (UV) that results mostly in the formation of cyclobutane pyrimidine dimers and (6-4) photoproducts. UV-damaged DNA interferes with DNA replication and transcription, and can lead to cell killing or mutagenesis if the damage is not properly repaired.
C45594	Protein_Sequence_Abnormality	Molecular_Abnormality	Protein Sequence Abnormality|Protein Sequence Alteration	A change in the amino acid sequence of a wild-type protein. This alteration typically occurs due to a mutation of the gene that encodes the protein. The change in amino acid sequence may enhance, reduce, abolish or have no effect on protein activity.
C45595	Protein_Splicing_Abnormality	Protein_Sequence_Abnormality	Protein Splicing Abnormality	A change in the amino acid sequence of a wild-type protein, resulting from aberrant excision of in-frame protein sequences (inteins) from a precursor protein followed by ligation of the flanking sequences (exteins).
C45596	Protein_Truncation_Abnormality	Protein_Sequence_Abnormality	Protein Truncation Abnormality|Protein Truncation|Truncation	Translation of a truncated form of a wild-type protein that originates from a mutation or mutations in the coding sequence of a gene. Genetic alterations that yield truncated protein products include frameshift mutations, nonsense mutations or splice site mutations. The activity of a truncated protein is usually reduced or abolished in comparison to the activity of the wild-type protein.
C45597	Coumarin_Compound	Heterocyclic_Compound	Coumarin Compound
C45598	CYP2C19_1_Allele	CYP2C19_Gene	CYP2C19*1 Allele|CYP2C19*1|CYP2C19, I331V|CYP2C19, c.991A>G|CYP2C19, wild-type|Cytochrome P450, Family 2, Subfamily C, Polypeptide 19*1 Allele	CYP2C19*1 allele is a variant form of the human CYP2C19 gene (cytochrome P450 family 2, subfamily C), located at 10q24.1-q24.3, which encodes the cytochrome P450 2C19 protein. CYP2C19*1A is the wild-type allele and exhibits no mutations. CP2C19*1B and CYP2C19*1C, haplotypes of this allele, both exhibit a clinically-relevant SNP (c.991A>G) in exon 7 that results in a I331V coding change. This alteration in protein sequence has no effect of the catalytic activity of the corresponding enzymes.
C45600	CYP2C19_2_Allele	CYP2C19_Gene	CYP2C19*2 Allele|CYP2C19*2|CYP2C19, c.681G>A|CYP2C19, m1|CYP2C19, m1A|CYP2C19, m1B|Cytochrome P450, Family 2, Subfamily C, Polypeptide 19*2 Allele	CYP2C19*2 allele is a variant form of the human CYP2C19 gene (cytochrome P450 family 2, subfamily C), located at 10q24.1-q24.3, which encodes the cytochrome P450 2C19 protein. CYP2C19*2 exhibits a clinically-relevant SNP (c.681G>A) in exon 5 that causes a splicing defect. This alteration results in a truncated CYP2C19*2 enzyme that is catalytically inactive.
C45601	Lung_Glandular_Papilloma	Glandular_Papilloma|Respiratory_Papilloma	Lung Glandular Papilloma
C45602	Lung_Mixed_Squamous_and_Glandular_Papilloma	Respiratory_Papilloma	Lung Mixed Squamous and Glandular Papilloma|Lung Mixed Squamous Cell and Glandular Papilloma
C45603	Lung_Pleomorphic_Adenoma	Lung_Adenoma|Pleomorphic_Adenoma	Lung Pleomorphic Adenoma
C45604	Lung_Mucinous_Cystadenoma	Benign_Lung_Neoplasm|Mucinous_Cystadenoma	Lung Mucinous Cystadenoma
C45605	Primary_Pulmonary_Diffuse_Large_B-Cell_Lymphoma	Diffuse_Large_B-Cell_Lymphoma|Lung_Non-Hodgkin_s_Lymphoma	Primary Pulmonary Diffuse Large B-Cell Lymphoma|High Grade MALT Lymphoma of the Lung
C45606	CYP2C19_3_Allele	CYP2C19_Gene	CYP2C19*3 Allele|CYP2C19*3|CYP2C19, W212X|CYP2C19, c.636G>A|CYP2C19, m2|Cytochrome P450, Family 2, Subfamily C, Polypeptide 19*3 Allele	CYP2C19*3 allele is a variant form of the human CYP2C19 gene (cytochrome P450 family 2, subfamily C), located at 10q24.1-q24.3, which encodes the cytochrome P450 2C19 protein. CYP2C19*3 exhibits a clinically-relevant SNP (c.636G>A) in exon 3 that results in a W212X coding change. This alteration in protein sequence abolishes the catalytic activity of the CYP2C19*3 enzyme.
C45607	Pulmonary_Lymphomatoid_Granulomatosis	Lung_Neoplasm|Lymphomatoid_Granulomatosis	Pulmonary Lymphomatoid Granulomatosis
C45608	CYP2C19_4_Allele	CYP2C19_Gene	CYP2C19*4 Allele|CYP2C19*4|CYP2C19, c.1A>G|CYP2C19, m3|Cytochrome P450, Family 2, Subfamily C, Polypeptide 19*4 Allele	CYP2C19*4 allele is a variant form of the human CYP2C19 gene (cytochrome P450 family 2, subfamily C), located at 10q24.1-q24.3, which encodes the cytochrome P450 2C19 protein. CYP2C19*4 exhibits a clinically-relevant SNP (c.1A>G) in the initiation codon that prevents translation of a protein product. Individuals who are heterozygous for this allele exhibit a poor metabolizer phenotype.
C45609	CYP2C19_5_Allele	CYP2C19_Gene	CYP2C19*5 Allele|CYP2C19*5|CYP2C19, R433W|CYP2C19, c.1297C>T|CYP2C19, m4|Cytochrome P450, Family 2, Subfamily C, Polypeptide 19*5 Allele	CYP2C19*5 allele is a variant form of the human CYP2C19 gene (cytochrome P450 family 2, subfamily C), located at 10q24.1-q24.3, which encodes the cytochrome P450 2C19 protein. CYP2C19*5 exhibits a clinically-relevant SNP (c.1297C>T) in exon 9 that results in a R433W coding change in the heme-binding region of the protein. This alteration in protein sequence abolishes the catalytic activity of the CYP2C19*5 enzyme.
C45610	CYP2C9_1_Allele	CYP2C9_Gene	CYP2C9*1 Allele|CYP2C9*1|CYP2C9, Wild-Type|CYP2C9, g.-2665delTG, g.-1188T>C|Cytochrome P450, Family 2, Subfamily C, Polypeptide 9*1 Allele	CYP2C9*1 allele is a variant form of the human CYP2C9 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C19 protein. CYP2C9*1A is the wild-type form and has no mutations. However, three other haplotypes of this allele exhibit a deletion (g.-2665delTG) and/or a SNP (g.-1188T>C) in the 5'- flanking region upstream of the gene. However, these nucleotide changes have no effect of the catalytic activity of the corresponding enzymes.
C45612	Lung_Soft_Tissue_Neoplasm	Lung_Neoplasm|Soft_Tissue_Neoplasm	Lung Soft Tissue Neoplasm
C45613	CYP2C9_2_Allele	CYP2C9_Gene	CYP2C9*2 Allele|CYP2C9*2|CYP2C9, R144C|CYP2C9, c.430C>T|Cytochrome P450, Family 2, Subfamily C, Polypeptide 9*2 Allele	CYP2C9*2 allele is a variant form of the human CYP2C9 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C19 protein. This allele exhibits a clinically-relevant SNP (c.430C>T) in exon 3 that results in a R144C coding change. This alteration in protein sequence decreases the catalytic activity of the CYP2C9*2 enzyme.
C45614	CYP2C9_3_Allele	CYP2C9_Gene	CYP2C9*3 Allele|CYP2C9*3|CYP2C9, I359L|CYP2C9, c.1075A>C|Cytochrome P450, Family 2, Subfamily C, Polypeptide 9*3 Allele	CYP2C9*3 allele is a variant form of the human CYP2C9 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C19 protein. This allele exhibits a clinically-relevant SNP (c.1075A>C) in exon 7 that results in an I359L coding change. This alteration in protein sequence decreases the catalytic activity of the CYP2C9*3 enzyme.
C45615	CYP2C9_5_Allele	CYP2C9_Gene	CYP2C9*5 Allele|CYP2C9*5|CYP2C9, D360E|CYP2C9, c.1080C>G|Cytochrome P450, Family 2, Subfamily C, Polypeptide 9*5 Allele	CYP2C9*5 allele is a variant form of the human CYP2C9 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C19 protein. This allele exhibits a clinically-relevant SNP (c.1080C>G) in exon 7 that results in a D360E coding change. This alteration in protein sequence increases the Km of the CYP2C9*3 enzyme for (S)-warfarin, diclofenac, and lauric acid, thereby decreasing clearance of these drugs.
C45616	CYP2D6_1_Allele	CYP2D6_Gene	CYP2D6*1 Allele|CYP2D6*1|CYP2D6, M4|CYP2D6, M5|CYP2D6, Wild-Type|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*1 Allele	CYP2D6*1 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. CYP2D6*1 is the wild-type form and exhibits no mutations. However, four other haplotypes of this allele exhibit SNPs that have no effect of the catalytic activity of the corresponding enzymes.
C45617	CYP2D6_10_Allele	CYP2D6_Gene	CYP2D6*10 Allele|CYP2D6*10|CYP2D6, P34S|CYP2D6, g.100C>T|CYP2D6J|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*10 Allele	CYP2D6*10 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a single nucleotide polymorphism (g.100C>T) that results in a P34S coding change. This alteration decreases the catalytic activity of the CYP2D6*10 enzyme.
C45618	CYP2D6_17_Allele	CYP2D6_Gene	CYP2D6*17 Allele|CYP2D6*17|CYP2D6, T107I, R296C|CYP2D6, g.1023C>T, g.2850C>T|CYP2D6Z|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*17 Allele	CYP2D6*17 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits two clinically-relevant SNPs (g.1023C>T, g.2850C>T) in that result in coding changes (T107I, R296C). These alterations decrease the catalytic activity of the CYP2D6*17 enzyme.
C45619	CYP2D6_2N_Allele	CYP2D6_Gene	CYP2D6*2N Allele|CYP2D6*2XN|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*2N Allele	CYP2D6*2N allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. Amplification of the CYP2D6 gene (up to 12 copies) produces the CYP2D6*2N allele. Although the catalytic activity of the resulting enzyme is not significantly different from wild-type, individuals who carry this allele exhibit an ultra-rapid metabolizer phenotype.
C45620	CYP2D6_4_Allele	CYP2D6_Gene	CYP2D6*4 Allele|CYP2D6(B)|CYP2D6*4|CYP2D6, K29-1|CYP2D6, g.1846G>A|CYP2D6B|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*4 Allele	CYP2D6*4 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a clinically-relevant SNP (g.1846G>A) at the consensus sequence of the splice site of intron 3 that results in a premature stop codon. This alteration yields a truncated CYP2D6*4 enzyme that is catalytically inactive.
C45621	CYP2D6_5_Allele	CYP2D6_Gene	CYP2D6*5 Allele|CYP2D6 Deleted|CYP2D6*5|CYP2D6, del|CYP2D6D|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*5 Allele	CYP2D6*5 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele results from deletion of the entire CYP2D6 gene. Thus, the CYP2D6*5 allele does not encode a CYP2D6 protein. This is the basis of the poor metabolizer phenotype in individuals who carry this allele.
C45622	CYP2D6_6_Allele	CYP2D6_Gene	CYP2D6*6 Allele|CYP2D6*6|CYP2D6, g.1707delT|CYP2D6T|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*6 Allele	CYP2D6*6 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a single nucleotide deletion (g.1707delT) in exon 3 that results in a frameshift and generates a stop codon one codon after the deletion. This alteration yields a truncated CYP2D6*6 enzyme that is catalytically inactive.
C45623	CYP2D6_8_Allele	CYP2D6_Gene	CYP2D6*8 Allele|CYP2D6*8|CYP2D6, g.1758G>T|CYP2D6G|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*8 Allele	CYP2D6*8 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a clinically-relevant SNP (g.1758G>T) in exon 3 that generates a stop codon. This alteration yields a truncated CYP2D6*8 enzyme that is catalytically inactive.
C45625	Malignant_Lung_and_Pleural_Neoplasm	Malignant_Thoracic_Neoplasm	Malignant Lung and Pleural Neoplasm
C45626	Type_I_Pleuropulmonary_Blastoma	Pleuropulmonary_Blastoma	Type I Pleuropulmonary Blastoma
C45627	Type_II_Pleuropulmonary_Blastoma	Pleuropulmonary_Blastoma	Type II Pleuropulmonary Blastoma
C45628	Type_III_Pleuropulmonary_Blastoma	Pleuropulmonary_Blastoma	Type III Pleuropulmonary Blastoma
C45629	Lung_Chondroma	Benign_Lung_Neoplasm|Extraskeletal_Chondroma|Lung_Soft_Tissue_Neoplasm	Lung Chondroma
C45630	Diffuse_Pulmonary_Lymphangiomatosis	Lung_Soft_Tissue_Neoplasm|Lymphangiomatosis	Diffuse Pulmonary Lymphangiomatosis
C45631	Lung_Synovial_Sarcoma	Lung_Sarcoma|Synovial_Sarcoma	Lung Synovial Sarcoma
C45632	Lung_Biphasic_Synovial_Sarcoma	Biphasic_Synovial_Sarcoma|Lung_Synovial_Sarcoma	Lung Biphasic Synovial Sarcoma
C45633	Lung_Monophasic_Synovial_Sarcoma	Lung_Synovial_Sarcoma|Monophasic_Synovial_Sarcoma	Lung Monophasic Synovial Sarcoma
C45634	Perivascular_Epithelioid_Cell	Epithelioid_Cell	Perivascular Epithelioid Cell|PEC	A perivascular cell with abundant clear or eosinophilic cytoplasm that contains glycogen. -- 2005
C45635	Translation_Initiation_Abnormality	Protein_Sequence_Abnormality	Translation Initiation Abnormality	An abnormality that results from a functional change in the mRNA sequence at the translation initiation codon. In eukaryotic organisms, the initiation codon is always AUG. A mutation in either DNA or corresponding mRNA that alters this initiation sequence causes termination of mRNA translation. No functional protein product is synthesized when a translation initiation abnormality exists.
C45636	Lung_Germ_Cell_Neoplasm	Extragonadal_Germ_Cell_Neoplasm|Lung_Neoplasm	Lung Germ Cell Tumor|Lung Germ Cell Neoplasm
C45637	Lung_Teratoma	Lung_Germ_Cell_Neoplasm|Teratoma	Lung Teratoma
C45638	Intrapulmonary_Thymoma	Lung_Neoplasm|Thymoma	Intrapulmonary Thymoma
C45639	Mediastinal_Thymoma	Mediastinal_Neoplasm|Thymoma	Mediastinal Thymoma
C45640	Adenosine_To_Guanine_Transition_Abnormality	Nucleotide_Transition_Abnormality	Adenosine to Guanosine Transition Abnormality|Adenosine to Guanosine Mutation|Adenosine to Guanosine Transition	A point mutation involving the substitution of Guanosine (a purine base) for Adenosine (a purine base) in a DNA sequence from eukaryotic or prokaryotic organisms. This abnormality can be either heritable or occur somatically.
C45641	Guanine_To_Adenosine_Transition_Abnormality	Nucleotide_Transition_Abnormality	Guanosine to Adenosine Transition Abnormality|Guanosine to Adenosine Mutation|Guanosine to Adenosine Transition	A point mutation involving the substitution of Adenosine (a purine base) for Guanosine (a purine base) in a DNA sequence from eukaryotic or prokaryotic organisms. This abnormality can be either heritable or occur somatically.
C45642	Thymidine_To_Cytosine_Transition_Abnormality	Nucleotide_Transition_Abnormality	Thymidine to Cytosine Transition Abnormality|Thymidine to Cytosine Mutation|Thymidine to Cytosine Transition	A point mutation involving the substitution of Cytosine (a pyrimidine base) for Thymidine (a pyrimidine base) in a DNA sequence from eukaryotic or prokaryotic organisms. This abnormality can be either heritable or occur somatically.
C45643	Cytosine_To_Thymidine_Transition_Abnormality	Nucleotide_Transition_Abnormality	Cytosine to Thymidine Transition Abnormality|Cytosine to Thymidine Mutation|Cytosine to Thymidine Transition	A point mutation involving the substitution of Thymidine (a pyrimidine base) for Cytosine (a pyrimidine base) in a DNA sequence from eukaryotic or prokaryotic organisms. This abnormality can be either heritable or occur somatically.
C45644	Adenosine_To_Thymidine_Transversion_Abnormality	Nucleotide_Transversion_Abnormality	Adenosine to Thymidine Transversion Abnormality|Adenosine to Thymidine Mutation|Adenosine to Thymidine Transversion	A point mutation involving the substitution of Thymidine (a pyrimidine base) for Adenosine (a purine base) in a DNA sequence from eukaryotic or prokaryotic organisms. This abnormality can be either heritable or occur somatically.
C45645	Adenosine_To_Cytosine_Transversion_Abnormality	Nucleotide_Transversion_Abnormality	Adenosine to Cytosine Transversion Abnormality|Adenosine to Cytosine Mutation|Adenosine to Cytosine Transversion	A point mutation involving the substitution of Cytosine (a pyrimidine base) for Adenosine (a purine base) in a DNA sequence from eukaryotic or prokaryotic organisms. This abnormality can be either heritable or occur somatically.
C45646	Guanine_To_Thymidine_Transversion_Abnormality	Nucleotide_Transversion_Abnormality	Guanosine to Thymidine Transversion Abnormality|Guanosine to Thymidine Mutation|Guanosine to Thymidine Transversion	A point mutation involving the substitution of Thymidine (a pyrimidine base) for Guanosine (a purine base) in a DNA sequence from eukaryotic or prokaryotic organisms. This abnormality can be either heritable or occur somatically.
C45647	Guanine_To_Cytosine_Transversion_Abnormality	Nucleotide_Transversion_Abnormality	Guanosine to Cytosine Transversion Abnormality|Guanosine to Cytosine Mutation|Guanosine to Cytosine Transversion	A point mutation involving the substitution of Cytosine (a pyrimidine base) for Guanosine (a purine base) in a DNA sequence from eukaryotic or prokaryotic organisms. This abnormality can be either heritable or occur somatically.
C45648	Thymidine_To_Adenosine_Transversion_Abnormality	Nucleotide_Transversion_Abnormality	Thymidine to Adenosine Transversion Abnormality|Thymidine to Adenosine Mutation|Thymidine to Adenosine Transversion	A point mutation involving the substitution of Adenosine (a purine base) for Thymidine (a pyrimidine base) in a DNA sequence from eukaryotic or prokaryotic organisms. This abnormality can be either heritable or occur somatically.
C45649	Thymidine_To_Guanine_Transversion_Abnormality	Nucleotide_Transversion_Abnormality	Thymidine to Guanosine Transversion Abnormality|Thymidine to Guanosine Mutation|Thymidine to Guanosine Transversion	A point mutation involving the substitution of Guanosine (a purine base) for Thymidine (a pyrimidine base) in a DNA sequence from eukaryotic or prokaryotic organisms. This abnormality can be either heritable or occur somatically.
C45650	Cytosine_To_Adenosine_Transversion_Abnormality	Nucleotide_Transversion_Abnormality	Cytosine to Adenosine Transversion Abnormality|Cytosine to Adenosine Mutation|Cytosine to Adenosine Transversion	A point mutation involving the substitution of Adenosine (a purine base) for Cytosine (a pyrimidine base) in a DNA sequence from eukaryotic or prokaryotic organisms. This abnormality can be either heritable or occur somatically.
C45651	Cytosine_To_Guanine_Transversion_Abnormality	Nucleotide_Transversion_Abnormality	Cytosine to Guanosine Transversion Abnormality|Cytosine to Guanosine Mutation|Cytosine to Guanosine Transversion	A point mutation involving the substitution of Guanosine (a purine base) for Cytosine (a pyrimidine base) in a DNA sequence from eukaryotic or prokaryotic organisms. This abnormality can be either heritable or occur somatically.
C45652	Lung_Melanoma	Malignant_Lung_Neoplasm|Melanoma	Lung Melanoma
C45653	Glycoside_Compound	Carbohydrate	Glycoside Compound
C45654	Multiple_Nucleotide_Abnormalities	Mutation_Abnormality	Multiple Nucleotide Abnormalities	Point mutations at various locations in a DNA sequence from either a eukaryotic or prokaryotic organism that causes a base change which results in an amino acid change in the protein product. This alteration may affect the stability and/or activity of the protein. Multiple mutation abnormalities may be heritable or occur spontaneously.
C45655	Sarcomatoid_Mesothelioma	Diffuse_Malignant_Mesothelioma|Malignant_Spindle_Cell_Neoplasm	Sarcomatoid Mesothelioma
C45656	Multiple_Transition_Abnormalities	Multiple_Nucleotide_Abnormalities	Multiple Transition Abnormalities|Multiple Transition Mutations|Transition Mutations	Multiple point mutations in a DNA sequence from eukaryotic or prokaryotic organisms in which each mutation occurs by substitution of a purine base for a different purine base or a pyrimidine base for another pyrimidine base. These abnormalities can be either heritable or occur somatically.
C45657	Multiple_Transversion_Abnormalities	Multiple_Nucleotide_Abnormalities	Multiple Transversion Abnormalities|Multiple Transversion Mutations|Transversion Mutations	Multiple point mutations in a DNA sequence from eukaryotic or prokaryotic organisms in which each mutation occurs by substitution of a purine base for a pyrimidine base or vice versa. These abnormalities can be either heritable or occur somatically.
C45658	Mixed_Nucleotide_Abnormalities	Multiple_Nucleotide_Abnormalities	Mixed Nucleotide Abnormalities|Mixed Mutations|Mixed Nucleotide Mutations	Point mutations at various locations in a DNA sequence from eukaryotic or prokaryotic organisms in which a nucleotide substitution, deletion or insertion has occurred at each affected site. These abnormalities can be either heritable or occur somatically.
C45659	Absence_of_Invasion	Morphologic_Finding	Absence of Invasion
C45660	Pleural_Well_Differentiated_Papillary_Mesothelioma	Pleural_Mesothelioma|Well-Differentiated_Papillary_Mesothelioma	Pleural Well Differentiated Papillary Mesothelioma
C45661	Peritoneal_Well_Differentiated_Papillary_Mesothelioma	Peritoneal_Mesothelioma|Well-Differentiated_Papillary_Mesothelioma	Peritoneal Well Differentiated Papillary Mesothelioma
C45662	Pleural_Epithelioid_Mesothelioma	Epithelial_Mesothelioma|Malignant_Pleural_Mesothelioma	Pleural Epithelioid Mesothelioma
C45663	Pleural_Sarcomatoid_Mesothelioma	Malignant_Pleural_Mesothelioma|Sarcomatoid_Mesothelioma	Pleural Sarcomatoid Mesothelioma
C45664	Pleural_Desmoplastic_Mesothelioma	Malignant_Fibrous_Mesothelioma|Malignant_Pleural_Mesothelioma	Pleural Desmoplastic Mesothelioma
C45665	Pleural_Biphasic_Mesothelioma	Malignant_Pleural_Mesothelioma|Mixed_Mesothelioma	Pleural Biphasic Mesothelioma
C45666	Localized_Pleural_Malignant_Mesothelioma	Localized_Malignant_Mesothelioma|Malignant_Pleural_Mesothelioma	Localized Pleural Malignant Mesothelioma
C45667	Atypical_Mesothelial_Hyperplasia	Atypical_Hyperplasia|Mesothelial_Hyperplasia	Atypical Mesothelial Hyperplasia
C45668	GPC3_Gene_Inactivation	Tumor-Suppressor_Gene_Inactivation	GPC3 Gene Inactivation
C45669	NF2_Gene_Mutation	Gene_Abnormality	NF2 Gene Mutation
C45670	_1H-Pyrazole	Pyrazole	Pyrazole|1,2-Diazole|1H-Pyrazol|1H-Pyrazole|Pyrazol	A heterocyclic organic compound characterized by a ring structure composed of three carbon atoms and two nitrogen atoms in adjacent positions, with the molecular formula C3H4N2.  Derivatives of pyrazole exhibit a variety of pharmacological properties, including those anti-inflammatory, anti-psychotic, antibiotic and anti-enzymatic. Some pyrazole derivatives are tubulin inhibitors with anti-angiogenic and antineoplastic properties. (NCI04)
C45671	Hidden	General_Modifier	Hidden	Not accessible to view.
C45672	Association_Class	UML_Entity	Association Class|Association	In UML modeling, an association that is also a class.  It not only connects a set of classes, but also defines a set of features that belong to the relationship itself. (ISO 11179)
C45673	Deriving	Properties_or_Attributes	Deriving	An explanation of the historical origins of a word, phrase, or object.
C45674	Enumerated	General_Modifier	Enumeration|Enumerated	The act of specifying individually; expressing as a list.
C45675	Non-enumerated	General_Modifier	Non-enumerated|Nonenumerated	Not individually specified; expressed as a descrition, text, or set of instructions.
C45676	Multiplicity	Conceptual_Entities	Multiplicity|Cardinality	The number of values for which a given condition holds; an indcation of how many objects may participate in a given relationship; the property of being multiple.
C45677	Template	Conceptual_Entities	Template	Something that establishes or serves as a pattern for reference; a form, mold, or pattern used as a guide to making something.
C45678	Industrial_Aid	Industrial_Product	Industrial Aid|Industrial Additive	Substances that are necessary in the manufacture and storage properties of industrial products, such as pharmaceuticals, foods, and cosmetics.  Examples include antioxidants, preservatives, flavoring agents, vehicles, and excipients. (NCI)
C45679	Restriction_Site_Polymorphism	Mutation_Abnormality	Restriction Site Polymorphism	An inherited change of a single base in a DNA sequence from an organism that changes the specific pattern of bases recognized and hydrolyzed by a restriction endonuclease enzyme. Restriction site polymorphisms can either create or abolish recognition sites for restriction enzymes.
C45680	Tandem_Repeat_Variation	Mutation_Abnormality	Tandem Repeat Variation	An inherited polymorphism in eukaryotic DNA that results from variations in the number of tandem repeat nucleotide sequences, which are end-to-end adjacent copies of a short (2 to 60 nucleotides) DNA sequence located between two restriction endonuclease recognition sites. These are referred to as variable number of tandem repeats (VNTR), and the number of alleles at these loci can vary from 2 to more than 20. VNTRs provide important genetic information that is used to identify an individual via the DNA fingerprinting technique.
C45681	CETP_B1_Allele	CETP_Gene	CETP B1 Allele|CETP B1	Expressed in liver, human CETP B1 Allele is a variant form of CETP Gene (BPI/LBP Family), which encodes Cholesterol Ester Transfer Protein, a secreted plasma protein involved in the transfer of insoluble cholesteryl esters among lipoproteins in the reverse transport of cholesterol, a vital step in normal cholesterol metabolism and homeostasis. HDL cholesterol concentration is inversely related to the risk of coronary artery disease. CETP has a central role in HDL metabolism and may affect susceptibility to atherosclerosis; defects cause CETP deficiency. CETP B1 contains a polymorphic TaqI restriction site in intron 1, absent in CETP B2. B2 individuals show lower CETP activity and concentrations and higher plasma HDL-cholesterol; the B1 variant is associated with higher CETP and lower HDL-cholesterol. Atherosclerotic progression is more prevalent in B1 subjects than B2 subjects.
C45682	CETP_B2_Allele	CETP_Gene	CETP B2 Allele|CETP B2	Expressed in liver, human CETP B2 Allele is a variant form of CETP Gene (BPI/LBP Family), which encodes Cholesterol Ester Transfer Protein, a secreted plasma protein involved in the transfer of insoluble cholesteryl esters among lipoproteins in the reverse transport of cholesterol, a vital step in normal cholesterol metabolism and homeostasis. HDL cholesterol concentration is inversely related to the risk of coronary artery disease. CETP has a central role in HDL metabolism and may affect susceptibility to atherosclerosis; defects cause CETP deficiency. CETP B2 lacks a polymorphic TaqI restriction site in intron 1, present in CETP B1. B2 individuals show lower CETP activity and concentrations and higher plasma HDL-cholesterol; the B1 variant is associated with higher CETP and lower HDL-cholesterol. Atherosclerotic progression is more prevalent in B1 subjects than B2 subjects.
C45683	ABCB1-C_Allele	ABCB1_Gene	ABCB1-C Allele|ABCB1-C|MDR1-C|MDR1-C Allele|P-Glycoprotein Transporter C Allele	Human ABCB1-C allele is the wild-type form of the human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) gene (ABC gene family), located at located at 7q21.1, which encodes multidrug resistance protein 1. Amplification of the ABCB1 gene is a major determinant in the development of multi-drug resistance which decreases the effectiveness of many chemotherapeutic agents used in cancer treatment.
C45684	ABCB1-T_Allele	ABCB1_Gene	ABCB1-T Allele|ABCB1, 3435C>T|ABCB1-T|ABCB1: c3435C>T|MDR1-T|MDR1-T Allele|P-Glycoprotein Transporter T Allele	Human ABCB1-T allele is a variant form of the human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) gene, located at 7q21.1, which encodes multidrug resistance protein 1. This allele exhibits a SNP (3435 C>T) in exon 26 that results in wobble. This alteration in DNA sequence decreases the in vivo catalytic activity of the protein encoded by the ABCB1-2 allele. Duodenal expression of multidrug resistance protein 1 is also significantly reduced in individuals that have a homozygous phenotype for this allele.
C45685	HTR2A-C_Allele	HTR2A_Gene	HTR2A-C Allele|5-Hydroxytryptamine (Serotonin) Receptor 2A A2 Allele|HTR2A A2|HTR2A A2 Allele|HTR2A C|HTR2A, 102T>C|HTR2A-C|HTR2A: g102T>C	HTR2A-C Allele is a variant form of 20-kb 3-exon human HTR2A Gene (GPCR1/5HT2 Family), which encodes Serotonin 5-HT-2A Receptor, a conserved integral membrane 5-HT/serotonin receptor protein involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production by association with G proteins that activate a PI-calcium second messenger system. 5-HT is a biogenic hormone that affects specific receptors as a neurotransmitter, hormone, or mitogen. HTR2A contains several polymorphic sites. Different alleles differ in the concentration of RNA and protein product of 5HTR2A. HTR2A-C Allele contains a single-nucleotide polymorphism (102 T>C) in an intron and is expressed at a lower level than the 102 C>T allele.
C45686	HTR2A-T_Allele	HTR2A_Gene	HTR2A-T Allele|5-Hydroxytryptamine (Serotonin) Receptor 2A A1 Allele|HTR2A A1|HTR2A A1 Allele|HTR2A T|HTR2A, 102C>T|HTR2A-T|HTR2A: g102C>T	HTR2A-T Allele is a variant form of 20-kb 3-exon human HTR2A Gene (GPCR1/5HT2 Family), which encodes Serotonin 5-HT-2A Receptor, a conserved integral membrane 5-HT/serotonin receptor protein involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production by association with G proteins that activate a PI-calcium second messenger system. 5-HT is a biogenic hormone that affects specific receptors as a neurotransmitter, hormone, or mitogen. HTR2A contains several polymorphic sites. Different alleles differ in the concentration of RNA and protein product of 5HTR2A. HTR2A-T Allele contains a single-nucleotide polymorphism (102 C>T) in an intron and is expressed at a higher level than the 102 T>C allele.
C45687	Pleural_Lymphoma	Lymphoma_by_Site|Malignant_Pleural_Neoplasm	Pleural Lymphoma|Primary Pleural Lymphoma
C45688	TPMT-1_Allele	TPMT_Gene	TPMT*1 Allele|TPMT Wild-type Allele|TPMT*1|TPMT, Wild-type	One of five major TPMT alleles, TPMT*1 Allele is the wild-type form of 34-kb 10-exon human TPMT Gene (TPMT Family), which encodes highly active monomeric 245-aa 28-kDa cytoplasmic Thiopurine S-Methyltransferase. Inhibited by S-adenosyl-L-homocysteine, TPMT catalyzes thiopurine S-methylation, an important metabolic pathway for thiopurine drugs such as 6-mercaptopurine. Individual tolerance, and therapeutic efficacy, of thiopurine drugs is associated with several polymorphisms, including base substitutions, that control levels of TPMT activity. TPMT activity varies among ethnic groups and is thought to be an important determinant of toxicity associated with thiopurine medications.
C45689	TPMT-3A_Allele	TPMT_Gene	TPMT*3A Allele|TPMT*3A|TPMT, 460G-A, 719A-G|TPMT, 460G>A, 719A>G|TPMT, ALA154THR, TYR240CYS|TPMT, G460A, A719G|TPMT-3A_Allele|TPMT: cG460A, A719G	One of five major TPMT alleles, TPMT*3A Allele is a variant form of 34-kb 10-exon human TPMT Gene (TPMT Family), which encodes polymorphic monomeric 245-aa 28-kDa cytoplasmic Thiopurine S-Methyltransferase. Inhibited by S-adenosyl-L-homocysteine, TPMT catalyzes thiopurine S-methylation, an important metabolic pathway for thiopurine drugs such as 6-mercaptopurine. TPMT*3A contains two transition point mutations (G460A, A719G) associated with Ala154Thr and Tyr240Cys substitutions. Each mutation alone reduces catalytic activity; both together eliminate activity. TPMT deficiency is associated with severe hematopoietic toxicity with standard doses of mercaptopurine, azathioprine, or thioguanine medications.
C45690	Amidino_TIC	Unclassified_Chemotherapy_Agent	Amidino TIC|1, 4-Benzenedicarboximidamide, N, N''-bis[4-[Imino(methylamino)methyl]phenyl]-, Tetrahydrochloride|1, 4-Benzenedicarboximidamide, N, N''-bis[4-[imino(methylamino)methyl]phenyl]-, tetrahydrochloride|HR 2166|Symetamine|Terephthalamidine|Terephthalamidine, N, N''-bis[p-(Methylamidino)phenyl]-, Tetrahydrochloride|Terephthalamidine, N, N''-bis[p-(methylamidino)phenyl]-, tetrahydrochloride	One of 800 terephthalanilides synthesized and tested preclinically in the late 1950's and early 1960's.  Chosen in the 1990's for further clinical investigation by the NCI's Project for the Review of Old Drugs because of its structure and activity spectrum.
C45691	Pyothorax-Associated_Lymphoma	Diffuse_Large_B-Cell_Lymphoma|Pleural_Lymphoma	Pyothorax-Associated Lymphoma|PAL
C45692	Pyothorax	Non-Neoplastic_Pleural_Disorder	Pyothorax
C45693	Pleural_Mass	Mass	Pleural Mass
C45694	EBV-Transformed_Late_Germinal_Center_Post-Germinal_Center_B-Lymphocyte	Mature_B-Lymphocyte	EBV-Transformed Late Germinal Center/Post-Germinal Center B-Lymphocyte	A B-lymphocyte that has been activated to be receptive to Epstein Barr virus and is found in the area of a lymph nodule containing aggregations of actively proliferating lymphocytes.
C45695	Pleural_Epithelioid_Hemangioendothelioma	Epithelioid_Hemangioendothelioma|Malignant_Pleural_Neoplasm	Pleural Epithelioid Hemangioendothelioma
C45696	Pleural_Synovial_Sarcoma	Malignant_Pleural_Neoplasm|Synovial_Sarcoma	Pleural Synovial Sarcoma
C45697	Pleural_Monophasic_Synovial_Sarcoma	Monophasic_Synovial_Sarcoma|Pleural_Synovial_Sarcoma	Pleural Monophasic Synovial Sarcoma
C45698	Pleural_Biphasic_Synovial_Sarcoma	Biphasic_Synovial_Sarcoma|Pleural_Synovial_Sarcoma	Pleural Biphasic Synovial Sarcoma
C45699	Minimally_Invasive_Thymoma	Invasive_Thymoma	Minimally Invasive Thymoma	A thymoma that focally infiltrates the surrounding capsule and invades the mediastinal fat.  This type of thymoma is usually recognized only after microscopic examination.  Grossly, it appears indistinguishable from encapsulated thymoma. -- 2005
C45700	Widely_Invasive_Thymoma	Invasive_Thymoma	Widely Invasive Thymoma	A thymoma that spreads by direct extension into adjacent tissues (lung, pericardium, or large vessels).  This type of thymoma usually appears invasive at the time of excision. -- 2005
C45702	Thymic_Medullary_Epithelial_Cell	Thymic_Epithelial_Cell	Thymic Medullary Epithelial Cell	An epithelial cell located in the inner portion of the thymus where the T lymphocytes become mature and are released into the circulation.
C45703	t_15_22_p11_q11	Chromosomal_Translocation	t(15;22)(p11;q11)
C45704	Thymic_Epithelial_Cell_Capable_of_Differentiating_Towards_Both_Cortical_and_Medullary_Type	Thymic_Epithelial_Cell	Thymic Epithelial Cell Capable of Differentiating Towards Both Cortical and Medullary Cell Type	A reticular epithelial cell generated in the thymus that, in optimal conditions, can become either a cortex type of thymus cell that mediates positive selection or a medullary type of thymus cell that mediates negative selection of developing thymocytes.
C45705	Thymic_Epithelial_Cell_Capable_of_Differentiating_Towards_Cortical_Cell_Type	Thymic_Epithelial_Cell	Thymic Epithelial Cell Capable of Differentiating Towards Cortical Cell Type	A reticular epithelial cell generated in the thymus that, in optimal condition, can become a cortex type of thymus cell that mediates positive selection of developing thymocytes.
C45706	Micronodular_Thymoma	Thymoma	Micronodular Thymoma|Micronodular Thymoma with Lymphoid B-Cell Hyperplasia|Micronodular Thymoma with Lymphoid Stroma	A rare type of thymoma characterized by the presence of multiple, well formed epithelial nodules separated by a lymphocytic stroma that usually contains germinal centers.  Reported cases have not been associated with recurrences or metastases. -- 2005
C45707	Metaplastic_Thymoma	Thymoma	Metaplastic Thymoma|Biphasic Thymoma Mixed Polygonal and Spindle Cell Type|Low Grade Thymic Metaplastic Carcinoma|Thymoma with Pseudosarcomatous Stroma	A rare type of well circumscribed or encapsulated thymoma with a biphasic architecture, consisting of epithelial cell islands and bundles of spindle cells.  The vast majority of reported cases had a benign clinical course. -- 2005
C45708	Microscopic_Thymoma	Thymoma	Microscopic Thymoma	A rare type of thymoma, composed of multifocal epithelial proliferations less than 1 mm in diameter.  This type of thymoma usually occurs in myasthenia gravis patients without any macroscopic (gross) evidence of tumor. -- 2005
C45709	Sclerosing_Thymoma	Thymoma	Sclerosing Thymoma	A rare type of thymoma, characterized by an exuberant amount of collagen-rich stroma. -- 2005
C45710	Thymic_Lipofibroadenoma	Benign_Thymus_Neoplasm	Thymic Lipofibroadenoma|Thymus Lipofibroadenoma	A recently reported thymic tumor, morphologically resembling fibroadenoma of the breast, and described in a patient with thymoma type B1 and pure red cell aplasia. -- 2005
C45711	Isothiocyanate	Sulfur_Compound	Isothiocyanate
C45713	Thymic_Epithelial_Tissue	Epithelial_Tissue|Thymic_Tissue	Thymic Epithelial Tissue
C45714	Epithelial_Tissue	Tissue	Epithelial Tissue
C45715	Glandular_Epithelial_Tissue	Epithelial_Tissue	Glandular Epithelial Tissue
C45716	Carcinoma_with_t_15_19_q13_p13_1_Translocation	Undifferentiated_Carcinoma	Carcinoma with t(15;19)(q13;p13.1) Translocation	A rare, aggressive carcinoma of unknown histogenesis, characterized by the presence of undifferentiated malignant cells affecting the mediastinum and other midline organs.  It is associated with the t(15;19)(q13;p13.1) translocation that generates the BRD4-NUT fusion oncogene. -- 2005
C45717	t_15_19_q13_p13_1	Chromosomal_Translocation	t(15;19)(q13;p13.1)
C45718	BRD4-NUT_Fusion_Protein_Expression	Fusion_Protein_Expression	BRD4-NUT Fusion Protein Expression
C45719	Thymic_Atypical_Carcinoid_Tumor	Thymus_Carcinoid_Tumor	Thymic Atypical Carcinoid Tumor	A primary thymic carcinoid tumor, characterized by a high mitotic rate often associated with the presence of necrosis and nuclear pleomorphism.  This type of thymic carcinoid tumor has a more aggressive clinical course, compared to typical thymic carcinoid tumors. -- 2005
C45720	Thymic_Typical_Carcinoid_Tumor	Thymus_Carcinoid_Tumor	Thymic Typical Carcinoid Tumor	A primary thymic carcinoid tumor, characterized by the presence of uniform, polygonal neoplastic cells, a low mitotic rate, and absence of necrosis. -- 2005
C45722	Combined_Thymic_Epithelial_Neoplasm	Thymus_Epithelial_Neoplasm	Combined Thymic Epithelial Neoplasm|Combined Thymic Epithelial Tumor|Composite Thymoma|Composite Thymoma-Thymic Carcinoma	A primary thymic epithelial neoplasm, characterized by the presence of at least two distinct areas, one representing a thymoma and the other a carcinoma.  The most aggressive component usually determines the clinical outcome. -- 2005
C45723	Thymic_Epithelial_Stem_Cell	Epithelial_Stem_Cell|Thymic_Epithelial_Cell	Thymic Epithelial Stem Cell	An epithelial cell that exists in the early fetal thymus that has the capacity to give rise to both cortical and medullary thymic epithelium.
C45724	GoMiner	Computer_Program	GoMiner	GoMiner is a tool for biological interpretation of 'omic' data, including data from gene expression microarrays. Omic experiments often generate lists of dozens or hundreds of genes that differ in expression between samples, raising the question: "What does it all mean biologically?" To answer this question, GoMiner leverages the Gene Ontology (GO) to identify the biological processes, functions and components represented in these lists. Instead of analyzing microarray results with a gene-by-gene approach, GoMiner classifies the genes into biologically coherent categories and assesses these categories. The insights gained through GoMiner can generate hypotheses to guide additional research. (http://discover.nci.nih.gov/gominer/)
C45725	Fishers_Exact_Test	Statistical_Methods	Fisher's Exact Test	Fisher's exact test is a statistical test used to determine if there are nonrandom associations between two categorical variables.  It is an alternative to the Chi-square test.
C45726	False_Positive	Test_Result	False Positive|False Alarm|False Discovery	A test result that shows evidence of a result or condition although it is not actually present.
C45727	BioCarta	Other_Agency_or_Organization	BioCarta	BioCarta is a developer, supplier and distributor of reagents and assays for biopharmaceutical and academic research. BioCarta aims to be the leader in the development and commercialization of new technology for functional proteomics by creating an international organization geared towards identifying, acquiring, and commercializing novel products. The BioCarta web site serves as an interactive web-based resource for life scientists. Their web site provides immediate access to existing life science research and integrates new data as it emerges. Broadly, this information falls into four categories: gene function, proteomic pathways, ePosters, and research reagents. BioCarta offers an easy and dynamic forum for information exchange and collaboration between researchers, educators and students. Scientists moderate BioCarta, and the site is open and without restriction or cost to participants. (from biocarta.com/about)
C45728	Concept_ISO	Terminology_Entity	Concept	A unit of knowledge created by a unique combination of characteristics. (ISO 1087)
C45732	Mediastinal_Germ_Cell_Tumor_with_Somatic-Type_Malignancy	Malignant_Mediastinal_Germ_Cell_Neoplasm	Mediastinal Germ Cell Tumor with Somatic-Type Malignancy
C45733	Mediastinal_Malignant_Germ_Cell_Tumor_with_Associated_Hematologic_Malignancy	Mediastinal_Malignant_Non-Seminomatous_Germ_Cell_Neoplasm	Mediastinal Malignant Germ Cell Tumor with Associated Hematologic Malignancy
C45734	Totipotent_Primordial_Germ_Cell	Primordial_Germ_Cell	Totipotent Primordial Germ Cell	One of the earliest cells of an organism that will be able to reproduce that kind of organism. It is able to develop into any variety of germ cell.
C45735	Pluripotent_Primordial_Germ_Cell	Primordial_Germ_Cell	Pluripotent Primordial Germ Cell
C45738	Mediastinal_Precursor_T_Lymphoblastic_Leukemia_Lymphoma	Malignant_Mediastinal_Neoplasm|Precursor_T_Lymphoblastic_Leukemia_Lymphoma	Mediastinal Precursor T-Lymphoblastic Lymphoma/Leukemia
C45739	Mediastinal_Precursor_T-Lymphoblastic_Leukemia	Mediastinal_Precursor_T_Lymphoblastic_Leukemia_Lymphoma|Precursor_T_Lymphoblastic_Leukemia	Mediastinal Precursor T-Lymphoblastic Leukemia
C45740	Mediastinal_Precursor_T-Lymphoblastic_Lymphoma	Mediastinal_Lymphoma|Mediastinal_Precursor_T_Lymphoblastic_Leukemia_Lymphoma|Precursor_T_Lymphoblastic_Lymphoma	Mediastinal Precursor T-Lymphoblastic Lymphoma|Primary Mediastinal Precursor T-Lymphoblastic Lymphoma
C45741	Mediastinal_Myeloid_Sarcoma	Malignant_Mediastinal_Neoplasm|Myeloid_Sarcoma	Mediastinal Myeloid Sarcoma
C45743	Mediastinal_Paraganglioma	Mediastinal_Neural_Neoplasm|Parasympathetic_Paraganglioma	Mediastinal Paraganglioma	A benign or malignant extra-adrenal parasympathetic paraganglioma that arises from paraganglia in the mediastinum.  Clinical signs and symptoms include chest pain, cough, hoarseness, and dysphagia.
C45744	Mediastinal_Solitary_Fibrous_Tumor	Benign_Mesenchymal_Mediastinal_Neoplasm|Solitary_Fibrous_Tumor	Mediastinal Solitary Fibrous Tumor
C45745	Histiocytoid_Cardiomyopathy	Cardiomyopathy	Histiocytoid Cardiomyopathy|Arachnocytosis of the Myocardium|Congenital Cardiomyopathy|Infantile Xanthomatous Cardiomyopathy|Isolated Cardiac Lipidosis|Myocardial Hamartoma|Oncocytic Cardiomyopathy|Purkinje Cell Hamartoma
C45746	Hamartoma_of_Mature_Cardiac_Myocytes	Benign_Myocardial_Neoplasm|Hamartoma	Hamartoma of Mature Cardiac Myocytes
C45747	Adult_Cardiac_Cellular_Rhabdomyoma	Adult_Rhabdomyoma|Cardiac_Rhabdomyoma	Adult Cardiac Cellular Rhabdomyoma
C45748	Ventricular_Myxoma	Endocardial_Myxoma	Ventricular Myxoma
C45749	Cardiac_Hemangioma	Benign_Cardiac_Neoplasm|Hemangioma	Cardiac Hemangioma
C45750	Cardiac_Cavernous_Hemangioma	Cardiac_Hemangioma|Cavernous_Hemangioma	Cardiac Cavernous Hemangioma
C45751	Cardiac_Capillary_Hemangioma	Capillary_Hemangioma|Cardiac_Hemangioma	Cardiac Capillary Hemangioma
C45752	Cardiac_Intramuscular_Hemangioma	Cardiac_Hemangioma|Intramuscular_Hemangioma	Cardiac Intramuscular Hemangioma
C45753	Cardiac_Inflammatory_Myofibroblastic_Tumor	Cardiac_Neoplasm|Inflammatory_Myofibroblastic_Tumor	Cardiac Inflammatory Myofibroblastic Tumor
C45754	Cystic_Tumor_of_Atrioventricular_Node	Benign_Cardiac_Neoplasm	Cystic Tumor of Atrioventricular Node|Benign Mesothelioma of Mahaim|Endodermal Rest|Intracardiac Endodermal Heterotopia|Mesothelioma of Atrioventricular Node|Tawarian Node
C45755	Cardiac_Malignant_Fibrous_Histiocytoma	Cardiac_Sarcoma|Malignant_Fibrous_Histiocytoma	Cardiac Malignant Fibrous Histiocytoma
C45756	Cardiac_Synovial_Sarcoma	Cardiac_Sarcoma|Synovial_Sarcoma	Cardiac Synovial Sarcoma
C45757	Cardiac_Biphasic_Synovial_Sarcoma	Biphasic_Synovial_Sarcoma|Cardiac_Synovial_Sarcoma	Cardiac Biphasic Synovial Sarcoma
C45758	Cardiac_Monophasic_Synovial_Sarcoma	Cardiac_Synovial_Sarcoma|Monophasic_Synovial_Sarcoma	Cardiac Monophasic Synovial Sarcoma
C45759	Cardiac_Rhabdomyosarcoma	Cardiac_Sarcoma|Rhabdomyosarcoma	Cardiac Rhabdomyosarcoma
C45760	Primary_Cardiac_Lymphoma	Retired_Concepts	Primary Cardiac Lymphoma
C45761	Pericardial_Germ_Cell_Tumor	Extragonadal_Germ_Cell_Neoplasm|Pericardial_Neoplasm	Pericardial Germ Cell Tumor
C45762	Metastatic_Neoplasm_to_the_Pericardium	Malignant_Pericardial_Neoplasm|Metastatic_Malignant_Neoplasm	Metastatic Malignant Neoplasm to the Pericardium|Metastatic Neoplasm to the Pericardium
C45763	Ensembl	Information_Resources	Ensembl	Ensembl is a joint project between EMBL-EBI and the Sanger Institute to develop a software system which produces and maintains automatic annotation on selected eukaryotic genomes. Ensembl is primarily funded by the Wellcome Trust.  The Ensembl Genome Browser can be accessed through www.ensembl.org.
C45764	Entrez	Information_Resources	Entrez	Entrez, the Life Sciences Search Engine, integrates the scientific literature, DNA and protein sequence databases, 3D protein structure and protein domain data, population study datasets, expression data, assemblies of complete genomes, and taxonomic information into a tightly interlinked system.  It is a product of the National Center for Biotechnology Information (NCBI).
C45765	Entrez_Gene	Information_Resources	Entrez Gene	NCBI's database for gene-specific information. It focuses on the genomes that have been completely sequenced, that have an active research community to contribute gene-specific information, or that are scheduled for intense sequence analysis. The content of Entrez Gene represents the result of curation and automated integration of data from NCBI's Reference Sequence project (RefSeq), from collaborating model organism databases, and from many other databases available from NCBI. (from Nucleic Acids Res. 2005; 33(Database Issue): D54-D58)
C45766	Genomic_Identifier	Identifier	Genomic Identifier	One or more characters and/or numbers that are used to identify, name, or characterize the nature, properties, or contents of genomic sequences, mRNA transcripts, protein products, or other class of entities that occurs throughout the genome.
C45767	AB_Term_Type	Term_Type_Property	AB Term Type|AB	The term type designation for "abbreviation".
C45768	AD_Term_Type	Term_Type_Property	AD Term Type|AD	The term type designation for the adjectival form of a noun.
C45769	AQ_Term_Type	Term_Type_Property	AQ Term Type|AQ	The term type designation for an "aniquated disease term".
C45770	BR_Term_Type	Term_Type_Property	BR Term Type|BR	The term type designation for the US brand name of a drug.
C45771	CI_Term_Type	Term_Type_Property	CI Term Type|CI	The term type designation for an ISO standard country code.
C45772	CU_Term_Type	Term_Type_Property	CU Term Type|CU	The term type designation for a US State Department standard country code.
C45773	CN_Term_Type	Term_Type_Property	CN Term Type|CN	The term type designation for a study code for a drug.
C45774	DN_Term_Type	Term_Type_Property	DN Term Type|DN	The term type designation for a "display name".
C45775	FB_Term_Type	Term_Type_Property	FB Term Type|FB	The term type designation for a foreign brand name of a drug.
C45776	HD_Term_Type	Term_Type_Property	HD Term Type|HD	The term type designation for a header term.
C45778	PT_Term_Type	Term_Type_Property	PT Term Type|PT	The term type designation for a preferred term (preferred name).
C45779	SN_Term_Type	Term_Type_Property	SN Term Type|SN	The term type designation for a chemical structure name.
C45780	SY_Term_Type	Term_Type_Property	SY Term Type|SY	The term type designation for a synonym.
C45781	Density	Characteristics	Density	The amount of something per unit size.
C45782	Background	Conceptual_Entities	Background	Existing conditions, especially those that would be confused with the phenomenon to be observed or measured.
C45783	Noise	Conceptual_Entities	Noise	Electrical or acoustic activity that can disturb communication.
C45784	X-Dimension	Dimension	X-Dimension	The magnitude of something in a horizontal direction.
C45785	Y-Dimension	Dimension	Y-Dimension	The magnitude of something in a vertical direction.
C45786	Spacing	Characteristics	Spacing	An intervening interval of space or time.
C45787	Mark	Properties_or_Attributes	Mark	A distinguishing symbol, a written or printed symbol, or a visible indication made on a surface.
C45788	Orientation	Properties_or_Attributes	Orientation	Position or alignment relative to points of the compass or other specific directions.
C45789	Circle	Conceptual_Entities	Circle|Circular	A ring-shaped structure with every point equidistant from the center.
C45790	Solvent	Reagent	Solvent	A liquid that dissolves or that is capable of dissolving; the component of a solution that is present in greater amount. (Online-Medical Dictionary)
C45791	Network_Address	Document_Type	Network Address|IP Address|Internet Protocol Address	A means of identifying and locating an individual computer on a computer network. This may include a name based address (i.e., ncicb.nci.nih.gov), or a numeric internet protocol address.
C45792	First-Line_Therapy	Treatment	First-Line Therapy|First Line Therapy|First Line Treatment|First-Line Treatment	The preferred standard treatment for a particular condition.
C45793	Reference_Point	Reference_Object	Reference Point	A specified location to which measurements are referred.
C45794	Mapping_Table	Conceptual_Entities	Mapping Table	A function, represented as a table, such that for every element of one set there is a unique element of another set.
C45795	JDBC_Driver	Computer_Program	JDBC Driver	An application program interface specification for connecting programs written in Java to the data in a database. It is a Java API that enables Java programs to execute SQL statements and interact with any SQL-compliant database. (letlingo.com)
C45796	TPMT_V3_Allele	TPMT_Gene	TPMT*V3 Allele|TPMT*V3|TPMT-V3	TPMT*V3 Allele is a variant form of 34-kb 10-exon human TPMT Gene (TPMT Family), which encodes polymorphic monomeric 245-aa 28-kDa cytoplasmic Thiopurine S-Methyltransferase. Inhibited by S-adenosyl-L-homocysteine, TPMT catalyzes thiopurine S-methylation, an important metabolic pathway for thiopurine drugs such as 6-mercaptopurine. TPMT contains a variable number of 17/18 bp tandem repeats (VNTR), from 3-9 (*V3-*V9), within the GC-rich 5'-flanking TPMT promoter region that modulate the level of TPMT enzyme activity (to a smaller extent than ORF-based SNP effects). A decrease in gene expression is seen with increasing repeat numbers. TPMT*V3 contains 3 VNTR. TPMT activity is thought to be an important determinant of toxicity associated with thiopurine medications.
C45797	TPMT_V4_Allele	TPMT_Gene	TPMT*V4 Allele|TPMT*V4|TPMT-V4	TPMT*V4 Allele is a variant form of 34-kb 10-exon human TPMT Gene (TPMT Family), which encodes polymorphic monomeric 245-aa 28-kDa cytoplasmic Thiopurine S-Methyltransferase. Inhibited by S-adenosyl-L-homocysteine, TPMT catalyzes thiopurine S-methylation, an important metabolic pathway for thiopurine drugs such as 6-mercaptopurine. TPMT contains a variable number of 17/18 bp tandem repeats (VNTR), from 3-9 (*V3-*V9), within the GC-rich 5'-flanking TPMT promoter region that modulate the level of TPMT enzyme activity (to a smaller extent than ORF-based SNP effects). A decrease in gene expression is seen with increasing repeat numbers. TPMT*V4 contains 4 VNTR. TPMT activity is thought to be an important determinant of toxicity associated with thiopurine medications.
C45798	TPMT_V5_Allele	TPMT_Gene	TPMT*V5 Allele|TPMT*V5|TPMT-V5	TPMT*V5 Allele is a variant form of 34-kb 10-exon human TPMT Gene (TPMT Family), which encodes polymorphic monomeric 245-aa 28-kDa cytoplasmic Thiopurine S-Methyltransferase. Inhibited by S-adenosyl-L-homocysteine, TPMT catalyzes thiopurine S-methylation, an important metabolic pathway for thiopurine drugs such as 6-mercaptopurine. TPMT contains a variable number of 17/18 bp tandem repeats (VNTR), from 3-9 (*V3-*V9), within the GC-rich 5'-flanking TPMT promoter region that modulate the level of TPMT enzyme activity (to a smaller extent than ORF-based SNP effects). A decrease in gene expression is seen with increasing repeat numbers. TPMT*V5 contains 5 VNTR. TPMT activity is thought to be an important determinant of toxicity associated with thiopurine medications.
C45799	National_Center_for_Biotechnology_Information	Component_of_the_National_Cancer_Institute	National Center for Biotechnology Information|NCBI	Established in 1988 as a national resource for molecular biology information, NCBI creates public databases, conducts research in computational biology, develops software tools for analyzing genome data, and disseminates biomedical information - all for the better understanding of molecular processes affecting human health and disease. (http://www.ncbi.nlm.nih.gov/)
C45800	Tree_Root	Terminology_Entity	Tree Root|Root	Concepts in a hierarchy are often said to be in a tree.  A root refers to a concept that is considered as the top node for a specific purpose.
C45801	Filter_Program	Computer_Program	Filter	A higher-order function which takes a predicate and a list and returns those elements of the list for which the predicate is true. It is a means of narrowing the scope of a report by specifying ranges or types of data to include or exclude. (Free On-Line Dictionary of Computing and Netlingo.com)
C45802	Matrix_Array	Array	Matrix|Matrix Array	A rectangular array of elements (or entries) set out by rows and columns.
C45803	Directed_Acyclic_Graph	Graph	Directed Acyclic Graph|DAG	A graph whose edges are ordered pairs of vertices or nodes and which contains no path that starts and ends at the same vertex (from NIST Dictionary of Algorithms and Data Structures).
C45804	Node	Other_Anatomic_Concept	Node	Any bulge or swelling of an anatomical structure or part.
C45805	Matrix	Other_Anatomic_Concept	Matrix	Ground substance in which things are embedded or that fills a space (e.g., extracellular matrix or nuclear matrix). (from On-line Medical Dictionary)
C45806	Lobular_Cancerization	Morphologic_Finding	Lobular Cancerization|COL|Cancerization of a Lobule	Lobular Cancerization (or cancerization of lobules, COL) is the presence in a lobule of ductal carcinoma in situ (DCIS) tumor cells with preservation of the normal lobular pattern. It appears to represents a variation in the growth pattern of DCIS, not secondary extension of DCIS into a lobule.
C45807	Gain_of_Chromosome_13q	Chromosomal_Gain	Gain of Chromosome 13q
C45808	Gain_of_Chromosome_22q	Chromosomal_Gain	Gain of Chromosome 22q
C45809	Gain_of_Chromosome_11q13	Chromosomal_Gain	Gain of Chromosome 11q13
C45810	CA_Repeat	Short_Tandem_Repeat	CA Repeat|CA/GT Repeat|GT Repeat|GT/CA Repeat	A dinucleotide repeat consisting of (CA/GT)n.
C45812	B_Vitamin	Water-Soluble_Vitamin	B Vitamin|B Vitamin Family|B Vitamins	A class of nutrients that are in the water-soluble B-vitamin family.  B vitamins include thiamine, riboflavin, niacin (nicotinic acid), niacinamide (nicotinamide), the vitamin B6 group (including pyridoxine, pyridoxal, pyridoxamine), biotin, pantothenic acid, folic acid, and possibly para-aminobenzoic.
C45813	Pellet_Formation	Centrifugation	Pellet Formation|Pellet	Formation by cetrifugation of a tightly packed sample in the bottom of a tube.
C45814	Genbank_Accession_Number_Versioned	UML_Entity	Versioned Genbank Accession Number|Genbank Accession Number, Versioned	A Genbank accession number with an explicit version.
C45822	Locus	Chromosome_Structure	Locus|Gene Locus	The position of a gene or a chromosomal marker on a chromosome; also, a stretch of DNA at a particular place on a particular chromosome. The use of locus is sometimes restricted to mean regions of DNA that are expressed.
C45824	Zygosity	Miscellaneous_Molecular_Biology_Terms	Zygosity	The genetic condition of a zygote, especially with respect to its being a homozygote or a heterozygote.
C45825	Heterozygous	Zygosity	Heterozygous	Having two different allelic form of a gene, one inherited from each parent, on each of the two homologous chromosomes.
C45826	Homozygous	Zygosity	Homozygous	Having two identical allelic form of a gene, one inherited from each parent, on each of the two homologous chromosomes.
C45827	Inheritance_Mode	Miscellaneous_Molecular_Biology_Terms	Inheritance Mode|Mode of Inheritance	The manner in which a particular genetic trait or disorder is passed from one generation to the next.
C45828	Approximate	Properties_or_Attributes	Approximate	Not quite exact or correct; almost exact or correct.
C45829	Absolute	Properties_or_Attributes	Absolute|Absolute Value	Complete and without restriction or qualification (sometimes used informally as an intensifier).
C45830	Relative_Value	Properties_or_Attributes	Relative Value|Relative	Considered in comparison with something else; dependent on or interconnected with something else; not absolute.
C45831	Nucleic_Acid_Strand	Miscellaneous_Molecular_Biology_Terms	Nucleic Acid Strand|Strand	A single chain of nucleotides.
C45832	Absolute_vs_Relative_Indicator	UML_Entity	Absolute vs Relative Indicator	An indicator that a measurement is reported as absolute or relative to some other measurement. (caMAGE)
C45833	Feature_Strand_Type	UML_Entity	Feature Strand Type	Indicates the direction and/or type of the SeqFeature, i.e. whether it is in the 5' or 3' direction, is double stranded, etc. (caMAGE)
C45834	Pancreatic_Endocrine_Microadenoma	Non-Functioning_Well_Differentiated_Pancreatic_Endocrine_Neoplasm	Pancreatic Endocrine Microadenoma	A well differentiated pancreatic endocrine neoplasm which measures less than 0.5 cm in diameter and it is not associated with a hormonal syndrome. -- 2005
C45835	Well_Differentiated_Pancreatic_Endocrine_Carcinoma	Pancreatic_Endocrine_Carcinoma	Well Differentiated Pancreatic Endocrine Carcinoma	A pancreatic endocrine carcinoma with a low grade malignant potential.  Grossly, it shows evidence of local invasion and/or metastases.
C45836	Functioning_Pancreatic_Endocrine_Neoplasm	Pancreatic_Endocrine_Neoplasm	Functioning Pancreatic Endocrine Tumor|Functioning Pancreatic Endocrine Neoplasm	A benign or malignant pancreatic endocrine neoplasm that is associated with a hormonal syndrome caused by inappropriate secretion of hormones from the islet cells.
C45837	Non-Functioning_Well_Differentiated_Pancreatic_Endocrine_Neoplasm	Non-Functioning_Pancreatic_Endocrine_Neoplasm|Well-Differentiated_Pancreatic_Endocrine_Neoplasm	Non-Functioning Well Differentiated Pancreatic Endocrine Tumor|Non-Functioning Well Differentiated Pancreatic Endocrine Neoplasm	A benign pancreatic endocrine neoplasm not associated with a hormonal syndrome. -- 2005
C45838	Non-Functioning_Well_Differentiated_Pancreatic_Endocrine_Carcinoma	Non-Functioning_Pancreatic_Endocrine_Neoplasm|Well_Differentiated_Pancreatic_Endocrine_Carcinoma	Non-Functioning Well Differentiated Pancreatic Endocrine Carcinoma	A pancreatic endocrine carcinoma which has a low grade malignant potential and it is not associated with a hormonal syndrome.
C45839	Suspension-Induced_Apoptosis	Apoptosis	Suspension-Induced Apoptosis|Anoikis|Detachment-Induced Cell Death	Anoikis (detachment induced cell death or suspension induced apoptosis) is the name given to a special form of cell death by apoptosis. It was observed initially after disruption of the interactions between normal epithelial cells and extracellular matrix. In an intact organism anoikis ensures that cells are unable to survive in an inappropriate location. Anoikis thus is apoptosis caused by cell isolation or apoptosis of cells in suspension or, generally speaking, apoptosis caused by loss of adherence to substrate. (from Cytokines Online Pathfinder Encyclopaedia)
C45840	Functioning_Well_Differentiated_Pancreatic_Endocrine_Neoplasm	Functioning_Pancreatic_Endocrine_Neoplasm|Well-Differentiated_Pancreatic_Endocrine_Neoplasm	Functioning Well Differentiated Pancreatic Endocrine Tumor|Functioning Well Differentiated Pancreatic Endocrine Neoplasm	A pancreatic endocrine neoplasm with indolent or uncertain behavior, associated with a hormonal syndrome. -- 2005
C45841	Functioning_Well_Differentiated_Pancreatic_Endocrine_Carcinoma	Functioning_Pancreatic_Endocrine_Neoplasm|Well_Differentiated_Pancreatic_Endocrine_Carcinoma	Functioning Well Differentiated Pancreatic Endocrine Carcinoma	A pancreatic endocrine carcinoma which has a low grade malignant potential and is associated with a hormonal syndrome. -- 2005
C45842	ERBB2_Protein	ErbB_Receptor_Family_Protein	ERBB2 Protein	The ERBB2 gene encodes two forms of ERBB2 protein.  One is a transmembrane protein that forms a heterodimer to act as the heregulin/neuregulin receptor. The other is a secreted form that consists only of the extracellular domain. It is capable of disrupting ERBB2 dimers thereby inhibiting growth.
C45843	Mixed_Exocrine-Endocrine_Carcinoma	Carcinoma|Malignant_Pancreatic_Neoplasm	Mixed Exocrine-Endocrine Carcinoma|Mixed Carcinoid-Adenocarcinoma of the Pancreas	A rare carcinoma with a poor prognosis, characterized by the presence of a mixture of exocrine and endocrine malignant epithelial cells in both the pancreas and metastatic sites.  Symptoms include jaundice, abdominal pain, and weight loss.
C45844	CT_Scanner	Imaging_Device	CT Scanner|Computerised (Axial) Tomography	CT (Computerised (Axial) Tomography) scanner is a special kind of machine which directs a series of X-ray pulses through the body, to produce detailed pictures of internal body structures.
C45845	Nitric_Oxide-Releasing_Compound	Adjuvant	Nitric Oxide-Releasing Compound|Nitric Oxide Donor Drug|Nitric Oxide-Donating Drug|Nitric Oxide-Releasing Drug
C45846	Extendable_Class	UML_Entity	Extendable Class|Extendable	Abstract class that specifies for subclasses an association to NameValueTypes.  These can be used, for instance, to specify proprietary properties and in-house processing hints. (NCI-SC)
C45847	Cardinal_Direction	Direction	Cardinal Direction	Any of the four principal astronomical directions on the surface of the earth: north, east, south, west. The Cardinal directions correspond to the following degrees of a compass: North: 0 degrees, East: 90 degrees, South: 180 degrees and West: 270 degrees.
C45848	Ordinal_Direction	Direction	Ordinal Direction	Ordinal directions are the four compass directions: northeast, southeast, southwest, and northwest, located halfway between the cardinal directions. (From Wikipedia)
C45849	North	Cardinal_Direction	North	North is one of the four primary cardinal directions, It is the direction toward the North Pole and is at 0 degree on a compass card. It is the direction to the left of sunrise.
C45850	South	Cardinal_Direction	South	South is one of the four primary cardinal directions. South is the direction toward the South Pole and is at 180 degree on a compass card. It is the direction to the right of sunrise.
C45851	East	Cardinal_Direction	East	East is one of the four primary cardinal directions. East is at 90 degree on a compass card. It is the direction of the sunrise.
C45852	West	Cardinal_Direction	West	West is one of the four primary cardinal directions. West is at 270 degree on a compass card. It is the direction of the sunset.
C45853	Northeast	Ordinal_Direction	Northeast	Northeast is the ordinal direction halfway between north and east. It is the opposite of southwest (From Wikipedia).
C45854	Northwest	Ordinal_Direction	Northwest	Northwest is the ordinal direction halfway between west and north on a compass. It is the opposite of southeast.(From Wikipedia).
C45855	Southeast	Ordinal_Direction	Southeast	Southeast is the ordinal direction halfway between south and east. It is the opposite of northwest (From Wikipedia).
C45856	Southwest	Ordinal_Direction	Southwest	Southwest is the ordinal direction halfway between south and west. It is the opposite of northeast (From Wikipedia).
C45857	Piloid_Astrocyte	Astrocyte	Piloid Astrocyte
C45858	Gain_of_Chromosome_4	Chromosomal_Gain	Gain of Chromosome 4
C45859	Loss_of_Chromosome_3q	Chromosomal_Loss	Loss of Chromosome 3q
C45860	Loss_of_Chromosome_1p36	Chromosomal_Loss	Loss of Chromosome 1p36
C45861	Loss_of_Chromosome_18q21	Chromosomal_Loss	Loss of Chromosome 18q21
C45863	Nickel_Hydroxide	Nickel_Compound	Nickel Hydroxide	A green, crystalline, inorganic compound that produces toxic gases upon heating. Nickel hydroxide is used in nickel-cadmium batteries and as a catalyst in chemical reactions. Exposure to this substance can cause severe dermatitis, skin and asthma-like allergies and affects the lungs, kidneys, gastrointestinal tract and neurological system. Nickel hydroxide is a known carcinogen and is associated with an increased risk of developing lung and nasal cancers. (NCI05)
C45864	Nickel_Monoxide	Nickel_Compound	Nickel Monoxide	A green to black colored, inorganic compound that turns yellow and produces toxic gases upon heating. Nickel monoxide is used in the electronics, ceramics, steel and alloy industries. Exposure to this substance can cause severe dermatitis, skin and asthma-like allergies and damages the lungs, kidneys, gastrointestinal tract and neurological system. Nickel monoxide is a known carcinogen and is associated with an increased risk of developing lung and nasal cancers. (NCI05)
C45866	Nickel_Sulfide	Nickel_Compound	Nickel Sulfide	A dark green to black colored, crystalline inorganic compound that produces toxic gases upon heating. Nickel sulfide is used in lithium batteries, as a catalyst in the petrochemical industry and is used in the manufacture of silicate-oxide nickel ores. Exposure to this substance can cause severe dermatitis, skin and asthma-like allergies and affects the lungs, kidneys, gastrointestinal tract and neurological system. Nickel sulfide is a known carcinogen and is associated with an increased risk of developing lung and nasal cancers. (NCI05)
C45867	Nickel_Acetate	Nickel_Compound	Nickel Acetate	A greenish, crystalline inorganic compound that produces toxic gases upon heating. Nickel acetate is used in textile dyeing processes, in electroplating, and as a catalyst intermediate. Exposure to this substance can cause severe dermatitis, skin and asthma-like allergies and causes damage to the lungs, kidneys, gastrointestinal tract and neurological system. Nickel acetate is a known carcinogen and is associated with an increased risk of developing lung and nasal cancers. (NCI05)
C45868	Nickel_Chloride	Nickel_Compound	Nickel Chloride	A green or yellow colored, crystalline inorganic compound that produces toxic gases upon heating. Nickel chloride is used in electroplating, in nickel catalysts and to absorb ammonia in industrial gas masks. Exposure to this substance can cause severe dermatitis, skin and asthma-like allergies and affects the lungs, kidneys, gastrointestinal tract and neurological system. Nickel chloride is a known carcinogen and is associated with an increased risk of developing lung and nasal cancers. (NCI05)
C45869	Nickel_Sulfate	Nickel_Compound	Nickel Sulfate	A yellow, green or blue colored, crystalline inorganic compound that produces toxic gases upon heating. Nickel sulfate is used in electroplating and as a chemical intermediate to produce other nickel compounds. Exposure to this substance can cause severe dermatitis, skin and asthma-like allergies and affects the lungs, kidneys, gastrointestinal tract and neurological system. Nickel sulfate is a known carcinogen and is associated with an increased risk of developing lung and nasal cancers. (NCI05)
C45870	Nickel_Carbonate	Nickel_Compound	Nickel Carbonate	A light green, crystalline inorganic compound that produces toxic gases upon heating. Nickel carbonate is used in electroplating, to prepare nickel monoxide, to make colored glass and as a catalyst in the treatment of wastewater. Exposure to this substance can cause severe dermatitis, skin and asthma-like allergies and affects the lungs, kidneys, gastrointestinal tract and neurological system. Nickel carbonate is a known carcinogen and is associated with an increased risk of developing lung and nasal cancers. (NCI05)
C45871	Nickel_Carbonyl	Nickel_Compound	Nickel Carbonyl	A colorless, volatile and highly flammable, liquid inorganic compound with a characteristic, musty odor that emits toxic carbon monoxide fumes upon heating. Nickel carbonyl is primarily used for nickel coatings and to manufacture high-purity nickel powder. Exposure to this substance can cause severe dermatitis, skin and asthma-like allergies and affects the lungs, kidneys, gastrointestinal tract and neurological system. Nickel carbonyl is a known carcinogen and is associated with an increased risk of developing lung and nasal cancers. (NCI05)
C45872	Nickelocene	Nickel_Compound	Nickelocene	A dark green colored, crystalline, inorganic compound that produces toxic gases upon heating. Nickelocene is used as a catalyst and as a complexing agent. Exposure to this substance can cause severe dermatitis, skin and asthma-like allergies and affects the lungs, kidneys, gastrointestinal tract and neurological system. Nickelocene is a known carcinogen and is associated with an increased risk of developing lung and nasal cancers. (NCI05)
C45873	EF5	Halogenated_Hydrocarbon	EF5|EF-5	A drug that is used to plan cancer treatment by measuring oxygen levels in tumor cells.
C45874	Dorsal	Anatomy_Modifier	Dorsal	Pertaining to the back or upper surface of the body; opposite of ventral.
C45875	Ventral	Anatomy_Modifier	Ventral	Pertaining to the underside or lower surface of the body; opposite of dorsal.
C45876	Beryllium_Chloride	Beryllium_Compound	Beryllium Chloride	A yellowish, crystalline, inorganic compound with a sharp odor that emits toxic fumes of beryllium oxides, hydrochloric acid and other chlorinated compounds upon heating. Beryllium chloride is mainly used to produce beryllium metal, but is also used as an acid catalyst in organic reactions. Inhalation exposure to its dust irritates the nose, throat and lungs and can cause pneumonitis. Prolonged exposure can result in a chronic beryllium disease called berylliosis causing granuloma and fibrosis formation in the lungs. Beryllium is a known human carcinogen and is associated with an increased risk of developing lung cancer. (NCI05)
C45877	Beryllium_Fluoride	Beryllium_Compound	Beryllium Fluoride	A white colored, crystalline, inorganic compound that emits toxic fumes of beryllium oxides, hydrofluoric acid and other fluorinated compounds upon heating. Beryllium fluoride is mainly used to produce beryllium metal and alloys and is also used in the production of glass and nuclear reactors. Inhalation exposure to its dust irritates the nose, throat and lungs and can cause pneumonitis. Prolonged exposure can result in a chronic beryllium disease called berylliosis causing granuloma and fibrosis formation in the lungs. Beryllium is a known carcinogen and is associated with an increased risk of developing lung cancer. (NCI05)
C45878	Beryllium_Hydroxide	Beryllium_Compound	Beryllium Hydroxide	A white colored, crystalline, inorganic compound that emits toxic fumes of beryllium oxides upon heating. Beryllium hydroxide is mainly used to produce beryllium metal and alloys. Inhalation exposure to its dust irritates the nose, throat and lungs and can cause pneumonitis. Prolonged exposure can result in a chronic beryllium disease called berylliosis causing granuloma and fibrosis formation in the lungs. Beryllium is associated with an increased risk of developing lung cancer. (NCI05)
C45879	Beryllium_Oxide	Beryllium_Compound	Beryllium Oxide	A white colored, crystalline, inorganic compound that emits toxic fumes of beryllium oxides upon heating. Beryllium oxide is widely used in industry due to its low density and high thermal and electrical conductivity. It is used in high-technology ceramics, electronic heat sinks, electrical insulators, high-power devices, high-density electrical circuits, microwaves, X-ray windows, nuclear reactor fuels and for various aerospace and military applications. Inhalation exposure to its dust irritates the nose, throat and lungs and can cause pneumonitis. Prolonged exposure can result in a chronic beryllium disease called berylliosis causing granuloma and fibrosis formation in the lungs. Beryllium is associated with an increased risk of developing lung cancer. (NCI05)
C45880	Beryllium_Metaphosphate	Beryllium_Compound	Beryllium Metaphosphate	A white colored, crystalline, inorganic compound that emits toxic fumes of beryllium oxides and phosphorus oxides upon heating. Beryllium metaphosphate is used in small amounts for special ceramic compositions and as a catalyst in organic reactions. Inhalation exposure to its dust irritates the nose, throat and lungs and can cause pneumonitis. Prolonged exposure can result in a chronic beryllium disease called berylliosis causing granuloma and fibrosis formation in the lungs. Beryllium is associated with an increased risk of developing lung cancer. (NCI05)
C45881	Beryllium_Sulfate	Beryllium_Compound	Beryllium Sulfate	A white colored, crystalline, inorganic compound that emits toxic fumes of beryllium oxides and sulfur oxides upon heating. Beryllium sulfate is mainly used to produce beryllium oxide for high-technology ceramics. Inhalation exposure to its dust and fumes irritates the nose, throat and lungs and can cause pneumonitis. Prolonged exposure can result in a chronic beryllium disease called berylliosis causing granuloma and fibrosis formation in the lungs. Beryllium is associated with an increased risk of developing lung cancer. (NCI05)
C45882	Beryl_Ore	Beryllium_Compound	Beryl Ore	A transparent, beryllium-containing, naturally occurring mineral that forms distinctive hexagonal crystals in a variety of colors due to different impurities that emits toxic fumes of beryllium oxides upon heating and is colorless in its pure form. Beryl ore is found in deeply buried rocks mainly in pegmatites. This mineral is primarily used to produce beryllium metal and beryllium compounds for use in high-technology applications in the nuclear, electronics, defense, aerospace and ceramics industry. Inhalation exposure to its dust and fumes irritates the nose, throat and lungs and can cause pneumonitis. Prolonged exposure can result in a chronic beryllium disease called berylliosis causing granuloma and fibrosis formation in the lungs. Beryllium is associated with an increased risk of developing lung cancer. (NCI05)
C45883	Beryllium-Copper_Alloy	Beryllium_Compound	Beryllium-Copper Alloy	A white colored, crystalline, inorganic compound composed of beryllium and copper in which beryllium increases the alloys thermal and electrical conductivity. This alloy emits toxic fumes of beryllium oxides upon heating. Beryllium-copper alloy is used in the electronics industry for numerous applications. Inhalation exposure to its dust and fumes irritates the nose, throat and lungs and can cause pneumonitis. Prolonged exposure can result in a chronic beryllium disease called berylliosis causing granuloma and fibrosis formation in the lungs. Beryllium is associated with an increased risk of developing lung cancer. (NCI05)
C45884	Beryllium-Aluminium_Alloy	Beryllium_Compound	Beryllium-Aluminium Alloy	A crystalline, inorganic compound composed of beryllium and copper in which beryllium increases the alloys thermal and electrical conductivity and emits toxic fumes of beryllium oxides upon heating. Beryllium-aluminium alloy is mainly used in light aircraft construction. Inhalation exposure to its dust and fumes irritates the nose, throat and lungs and can cause pneumonitis. Prolonged exposure can result in a chronic beryllium disease called berylliosis causing granuloma and fibrosis formation in the lungs. Beryllium is associated with an increased risk of developing lung cancer. (NCI05)
C45885	Calcium_Chromate	Chromium_Hexavalent_Compound	Calcium Chromate	A yellowish, crystalline, inorganic compound that emits toxic chromium fumes upon heating. Calcium chromate is highly corrosive and is a strong oxidizing agent. This substance is mainly used as a corrosion inhibitor and as a depolarizer in batteries. Calcium chromate primarily affects the nose, throat and lungs causing ulcerations, shortness of breath, bronchitis, pneumonia and asthma-like allergy but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity. (NCI05)
C45886	Chromium_Trioxide	Chromium_Hexavalent_Compound	Chromium Trioxide	A dark red to brown colored, crystalline, inorganic compound that emits toxic chromium fumes upon heating. Chromium trioxide is highly corrosive and is a strong oxidizing agent. This substance is mainly used in the production of wood preservatives and organic chemicals, but is also used in metal finishing and chrome plating and as a corrosion inhibitor. Chromium trioxide primarily affects the nose, throat and lungs causing ulcerations, shortness of breath, bronchitis, pneumonia and asthma-like allergy but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity. (NCI05)
C45887	Sodium_Chromate	Chromium_Hexavalent_Compound	Sodium Chromate	A yellowish, crystalline, inorganic compound that emits toxic chromium fumes upon heating. Sodium chromate is highly corrosive and is a strong oxidizing agent. This substance is used in wood preservatives, drilling muds, cutting oils, water treatment, textile dyeing processes, inks, paints, leather tanning and as a corrosion inhibitor. Sodium chromate primarily affects the respiratory tract causing ulcerations, shortness of breath, bronchitis, pneumonia and asthma but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity. (NCI05)
C45888	Sodium_Dichromate	Chromium_Hexavalent_Compound	Sodium Dichromate	An orange to red colored, crystalline, inorganic compound that emits toxic chromium fumes upon heating. Sodium dichromate is highly corrosive and is a strong oxidizing agent. This substance is mainly used to produce other chromium compounds, but is also used in drilling muds, in metal treatments, in wood preservatives, in the production of dyes and organic chemicals and as a corrosion inhibitor. Sodium dichromate primarily affects the respiratory system causing ulcerations, shortness of breath, bronchitis, pneumonia and asthma but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity. (NCI05)
C45889	Potassium_Chromate	Chromium_Hexavalent_Compound	Potassium Chromate	A yellowish, crystalline, inorganic compound that emits toxic chromium fumes upon heating. Potassium chromate is highly corrosive and is a strong oxidizing agent. This substance is used in the manufacture of dyes and in textile dyeing processes. Potassium chromate primarily affects the nose, throat and lungs causing ulcerations, shortness of breath, bronchitis, pneumonia and asthma but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity. (NCI05)
C45890	Potassium_Dichromate	Chromium_Hexavalent_Compound	Potassium Dichromate	An orange to red colored, crystalline, inorganic compound that emits toxic chromium fumes upon heating. Potassium dichromate is highly corrosive and is a strong oxidizing agent. This substance is used in wood preservatives, in the manufacture of pigments and in photomechanical processes, but is mainly replaced by sodium dichromate. Potassium dichromate primarily affects the respiratory tract causing ulcerations, shortness of breath, bronchitis, pneumonia and asthma but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity. (NCI05)
C45891	Lead_Chromate	Chromium_Hexavalent_Compound|Lead_Compound	Lead Chromate	A yellow, orange or red colored, crystalline, inorganic compound that emits toxic chromium fumes upon heating. Lead chromate is highly corrosive and is a strong oxidizing agent. This substance is used in printing inks, paints and to color vinyl, rubber and paper. Lead chromate primarily affects the lungs causing shortness of breath, bronchitis, pneumonia and asthma but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity. (NCI05)
C45892	Strontium_Chromate	Chromium_Hexavalent_Compound	Strontium Chromate	A yellowish, crystalline, inorganic compound that emits toxic chromium fumes upon heating. Strontium chromate is highly corrosive and is a strong oxidizing agent. This substance is used as a colorant in polyvinyl chloride, in pyrotechnics, in chrome plating, in aluminium flake coatings, and as a corrosion inhibitor and metal conditioner. Strontium chromate primarily affects the lungs causing shortness of breath, bronchitis, pneumonia and asthma but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity. (NCI05)
C45893	Zinc_Chromate	Chromium_Hexavalent_Compound	Zinc Chromate	A yellowish, crystalline, inorganic compound that emits toxic chromium fumes upon heating. Zinc chromate is highly corrosive and is a strong oxidizing agent. This substance is used as a corrosion inhibitor, metal conditioner and is used in paints, varnishes and oil colors. Zinc chromate primarily affects the lungs causing shortness of breath, bronchitis, pneumonia and asthma but can also affect the gastrointestinal tract, liver, kidneys and immune system. This substance is a known human carcinogen and is associated with an increased risk of developing lung cancer and cancer of the sinonasal cavity. (NCI05)
C45894	Cadmium_Chloride	Cadmium_Compound	Cadmium Chloride	A whitish, crystalline, inorganic compound that forms toxic fumes of cadmium oxides when heated. Calcium chloride is used in electroplating, printing, photocopying, dyeing, mirrors, vacuum tubes, lubricants, analytical chemistry and as a chemical intermediate to produce cadmium containing pigments and stabilizers. Exposure to this substance irritates the eyes, skin and respiratory tract and causes damage to the lungs resulting in shortness of breath, chest pain and pulmonary edema, and can also damage the kidneys causing proteinuria and decreased renal function. Calcium chloride is a known carcinogen and is associated with an elevated risk of developing lung cancer. (NCI05)
C45895	Cadmium_Sulfate	Cadmium_Compound	Cadmium Sulfate	A whitish, crystalline, inorganic compound that forms toxic fumes of cadmium oxides when heated. Calcium sulfate is used in electroplating, vacuum tubes, fluorescent screens, analytical chemistry, as a fungicide and as a chemical intermediate to produce cadmium containing pigments and stabilizers. Exposure to this substance irritates the eyes, skin and respiratory tract and causes damage to the lungs resulting in shortness of breath, chest pain and pulmonary edema, and can also damage the kidneys causing proteinuria and decreased renal function. Calcium sulfate is a known carcinogen and is associated with an elevated risk of developing lung cancer. (NCI05)
C45896	Cadmium_Nitrate	Cadmium_Compound	Cadmium Nitrate	A colorless, crystalline, inorganic compound that forms toxic fumes of cadmium oxides when heated. Calcium nitrate is used in the production of cadmium hydroxide for use in alkaline batteries, to color glass and porcelain, in photography and in nuclear reactors. Exposure to this substance irritates the eyes, skin and respiratory tract and causes damage to the lungs resulting in shortness of breath, chest pain and pulmonary edema, and can also damage the kidneys causing proteinuria and decreased renal function. Calcium nitrate is a known carcinogen and is associated with an elevated risk of developing lung cancer. (NCI05)
C45897	Cadmium_Oxide	Cadmium_Compound	Cadmium Oxide	A dark brown colored, crystalline, inorganic compound that forms toxic fumes of cadmium oxides when heated. Calcium oxide is mainly used in nickel-cadmium batteries, but is also used in electroplating, in the production of plastics and nitrile rubbers and as a nematocide and ascaricide in swine. Exposure to this substance irritates the eyes, skin and respiratory tract and causes damage to the lungs resulting in shortness of breath, chest pain and pulmonary edema, and can also damage the kidneys causing proteinuria and decreased renal function. Calcium oxide is a known carcinogen and is associated with an elevated risk of developing lung cancer. (NCI05)
C45898	Cadmium_Sulfide	Cadmium_Compound	Cadmium Sulfide	A yellow to orange colored, crystalline, inorganic compound that forms toxic fumes of cadmium oxides when heated. Calcium sulfide is used as pigment in paints, plastics, textiles, ceramic and glass and is also used in solar cells, smoke and radiation detectors, light-emitting diodes and photomultipliers. Exposure to this substance irritates the eyes, skin and respiratory tract and causes damage to the lungs resulting in shortness of breath, chest pain and pulmonary edema, and can also damage the kidneys causing proteinuria and decreased renal function. Calcium sulfide is a known carcinogen and is associated with an elevated risk of developing lung cancer. (NCI05)
C45899	FACT-G_Questionnaire	Clinical_Assessment_Tool	FACT-G Questionnaire|FACT-G|Functional Assessment of Cancer Therapy General Questionaire	A general quality of life instrument intended for use with a variety of chronic illness conditions. A core instrument in the Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System, a system which has multiple disease-, treatment-, and condition-specific subscales to complement the FACT-G. (from http://www.atsqol.org/fact-g.asp)
C45900	FACT-BMT_Questionnaire	Clinical_Assessment_Tool	FACT-BMT Questionnaire|FACT-BMT|Functional Assessment of Cancer Therapy Bone Marrow Transplant Questionnaire	A subscale complement to the FACT-G developed specifically for evaluating quality of life of bone marrow transplant (BMT) patients.
C45902	Alcoholic_Beverage	Carcinogenic_Mixture	Alcoholic Beverage	A drink, either beer, wine or liquor, that is made by fermentation of raw materials and consists mostly of ethanol and water but also contains numerous known or suspected carcinogens including acetaldehyde, aflatoxins, asbestos, nitrosamines, urethane and arsenic compounds. Consumption of this substance may cause local irritation of the upper gastrointestinal tract and affects the central nervous system. Prolonged and excessive drinking causes fatty liver, liver cirrhosis and jaundice. Alcoholic beverage is a known human carcinogen and is associated with an increased risk of developing cancer of the esophagus, pharynx, larynx and mouth and may be associated with liver and breast cancer. (NCI05)
C45907	Promethazine_Hydrochloride	Promethazine	Promethazine Hydrochloride|Anergan|N-(2-Dimethylaminopropyl-1)phenothiazine Hydrochloride|PROMETHAZINE HYDROCHLORIDE|Phenergan|Promethazine HCl|Remsed|Zipan
C45908	Intersex	General_Modifier	Intersex|Intersexed	A person (one of unisexual specimens) who is born with genitalia and/or secondary sexual characteristics of indeterminate sex, or which combine features of both sexes.
C45909	Hermaphrodite	General_Modifier	Hermaphrodite	An organism having both male and female sexual characteristics and organs.
C45910	Pooled_Sample	Specimen	Pooled Sample|Pooled|Pooled Specimen	A mix of specimens from multiple individuals representing multiple sex groups.
C45911	Tuberculum_Sellae	Musculoskeletal_System_Part	Tuberculum Sellae
C45912	Pituitary_Stalk	Brain_Part	Pituitary Stalk
C45914	Acyl-CoA_Synthetase_Long-Chain_Family_Member_1	Ligase	Acyl-CoA Synthetase Long-Chain Family Member 1|ACS1|Acyl-CoA Synthetase 1|FACL1|FACL2|Fatty-Acid-Coenzyme A Ligase|Fatty-Acid-Coenzyme A Ligase, Long-Chain 1|Fatty-Acid-Coenzyme A Ligase, Long-Chain 2|LACS 1|LACS 2|Lignoceroyl-CoA Synthase|Long-Chain Acyl-CoA Synthetase 1|Long-Chain Acyl-CoA Synthetase 2|Long-Chain-Fatty-Acid CoA Ligase 1|Long-Chain-Fatty-Acid CoA Ligase 2|Palmitoyl-CoA Ligase 1|Palmitoyl-CoA Ligase 2	Expressed as alternative isoforms in liver, heart, skeletal muscle, kidney, early erythroid cells, brain, lung, placenta and pancreas by human ACSL1 Gene (Long-Chain Fatty-Acid-CoA Ligase Family), 698-aa 78 kDa Acyl-CoA Synthetase Long-Chain Family Member 1 is a magnesium-cofactor type III membrane protein likely located in microsomes, outer mitochondrial membranes and peroxisomal membranes. Preferentially using palmitoleate, oleate and linoleate, ACSL1 converts free long-chain fatty acids into fatty acyl-CoA esters for biosynthesis of cellular lipids and degradation via beta-oxidation.
C45915	Gonadotropin_Producing_Pituitary_Gland_Adenoma	Pituitary_Gland_Adenoma	Gonadotropin Producing Pituitary Gland Adenoma|Gonadotropin Secreting Pituitary Gland Adenoma	An adenoma of the anterior lobe of the pituitary gland that produces gonadotrophic hormones (FSH and/or LH) or shows evidence towards gonadotroph differentiation.  The majority of cases are hormonally non-functional.  Clinical manifestations include visual disturbances, hypopituitarism, headache, and acute hemorrhagic necrosis of the pituitary gland. (NCI05)
C45916	Plurihormonal_Pituitary_Gland_Adenoma	Pituitary_Gland_Adenoma	Plurihormonal Pituitary Gland Adenoma|Multihormonal Adenoma|Multihormonal Pituitary Gland Adenoma|Plurihormonal Adenoma	An infrequent chromophobic or slightly eosinophilic pituitary gland adenoma that shows immunoreactivity for more than one pituitary hormone, excluding the following two combinations: growth hormone/prolactin/TSH, and FSH/LH. (NCI05)
C45917	Pituitary_Gland_Gangliocytoma	Gangliocytoma|Pituitary_Gland_Neoplasm	Pituitary Gland Gangliocytoma|Adenohypophysial Choristoma	A tumor characterized by the presence of mature ganglion cells and neuronal differentiation, arising in the pituitary gland.  It is often associated with the presence of pituitary gland adenomas.  Symptoms include acromegaly and precocious puberty. (NCI05)
C45918	Hypothalamic_Gangliocytoma	Gangliocytoma|Hypothalamic_Neoplasm	Hypothalamic Gangliocytoma	A tumor characterized by the presence of mature ganglion cells and neuronal differentiation, arising in the hypothalamus.  It is often associated with the presence of pituitary gland adenomas.  Symptoms include acromegaly and precocious puberty. (NCI05)
C45919	Pituicyte	Glial_Cell	Pituicyte	A cell of the neural lobe of the hypophysis. It has long branching processes and resembles neuroglia. It secretes antidiuretic hormone.
C45920	Adenohypophysial_Cell	Endocrine_Cell_and_Neuroendocrine_Cell|Glandular_Cell	Adenohypophysial Cell	One of five types of secreting cells (somatotrophs, lactotrophs, corticotrophs, thyrotrophs, and gonadotrophs) found in the anterior lobe of the pituitary gland.
C45921	Anterior_Pituitary_Gland_Neoplasm	Endocrine_Neoplasm|Pituitary_Gland_Neoplasm	Anterior Pituitary Gland Neoplasm|Neoplasm of the Anterior Lobe of the Pituitary Gland	A neoplasm arising from the anterior lobe of the pituitary gland.  The vast majority are adenomas. (NCI05)
C45922	Pituitary_Gland_Neoplasm_Antiquated	Neoplasm_by_Obsolete_Classification	Pituitary Gland Neoplasm (Antiquated)
C45924	Null_Cell_Pituitary_Gland_Adenoma	Non-Functioning_Pituitary_Gland_Adenoma	Null Cell Pituitary Gland Adenoma|Hormone Immunonegative Adenoma|Hormone Immunonegative Pituitary Gland Adenoma|Null Cell Adenoma	A non-functioning pituitary gland adenoma without hormonal immunoreactivity or evidence of specific adenohypophysial cell derivation. (NCI05)
C45925	Densely_Granulated_Pituitary_Gland_Somatotroph_Adenoma	Growth_Hormone_Secreting_Pituitary_Adenoma	Densely Granulated Pituitary Gland Somatotroph Adenoma|Densely Granulated Somatotroph Adenoma	A growth hormone producing pituitary gland adenoma composed of medium-sized acidophilic cells with granular cytoplasm and abundant secretory granules. (NCI05)
C45926	Sparsely_Granulated_Pituitary_Gland_Somatotroph_Adenoma	Growth_Hormone_Secreting_Pituitary_Adenoma	Sparsely Granulated Pituitary Gland Somatotroph Adenoma|Sparsely Granulated Somatotroph Adenoma	A growth hormone producing pituitary gland adenoma composed of small, round cells containing fibrous bodies and scarce, small secretory granules. (NCI05)
C45927	Mixed_Somatotroph-Lactotroph_Pituitary_Gland_Adenoma	Pituitary_Gland_Adenoma	Mixed Somatotroph-Lactotroph Pituitary Gland Adenoma|Mixed GH-PRL Cell Adenoma|Mixed Somatotroph-Lactotroph Adenoma	An infrequent pituitary gland adenoma composed of an admixture of acidophilic and chromophobic cells that produce growth hormone and prolactin respectively.  Unlike mammosomatotroph adenomas, these two hormones are not localized in the same cell by immunohistochemistry. (NCI05)
C45928	Mammosomatotroph_Pituitary_Gland_Adenoma	Pituitary_Gland_Adenoma	Mammosomatotroph Pituitary Gland Adenoma|Mammosomatotroph Adenoma	A pituitary gland adenoma composed of acidophilic cells that produce both growth hormone and prolactin.  Immunohistochemical studies reveal the presence of these two hormones localized in the same cell. (NCI05)
C45929	Acidophil_Stem_Cell_Pituitary_Gland_Adenoma	Pituitary_Gland_Adenoma	Acidophil Stem Cell Pituitary Gland Adenoma|Acidophil Stem Cell Adenoma	An infrequent pituitary gland adenoma composed of cells showing immunoreactivity for prolactin and less often growth hormone.  Electron microscopic studies reveal giant mitochondria, a finding not present in any other type of pituitary gland adenomas. (NCI05)
C45930	Gsalpha_Gene_Mutation	Gene_Abnormality	Gsalpha Gene Mutation
C45931	Densely_Granulated_Pituitary_Gland_Lactotroph_Adenoma	Prolactin_Secreting_Pituitary_Gland_Adenoma	Densely Granulated Pituitary Gland Lactotroph Adenoma	A rare prolactin producing pituitary gland adenoma composed of acidophilic cells with many large secretory granules.  The endoplasmic reticulum is not as abundant as in the sparsely granulated subtype. (NCI05)
C45932	Sparsely_Granulated_Pituitary_Gland_Lactotroph_Adenoma	Prolactin_Secreting_Pituitary_Gland_Adenoma	Sparsely Granulated Pituitary Gland Lactotroph Adenoma	A prolactin producing pituitary gland adenoma composed of relatively large, chromophobic or slightly acidophilic cells with well developed, abundant endoplasmic reticulum, and many immature secretory granules.  Mature secretory granules are sparse. (NCI05)
C45933	Gain_of_Chromosome_4q	Chromosomal_Gain	Gain of Chromosome 4q
C45934	HRAS_Gene_Mutation	Oncogene_Deregulation	HRAS Gene Mutation
C45935	Pituitary_Gland_Oncocytoma	Null_Cell_Pituitary_Gland_Adenoma|Oxyphilic_Adenoma	Pituitary Gland Oncocytic Adenoma|Null Cell Pituitary Gland Adenoma, Oncocytic Variant	A null cell pituitary gland adenoma, characterized by the presence of eosinophilic cells and mitochondrial abundance.  (NCI05)
C45936	Premature_Termination_Abnormality	Mutation_Abnormality	Premature Termination Abnormality|Premature Termination Mutation	A state of anomaly derived from mutations, which create new stop codons that precedes the stop codon of a wildtype counterpart.  The These mutations may be induced by certain types of mutagens or may occur spontaneously.
C45937	Somatotroph	Retired_Concepts	Somatotroph Cell|Somatotroph	An acidophil of the adenohypophysis that stains preferentially with orange G and secretes growth hormone.
C45938	Neoplastic_Somatotroph_Cell	Retired_Concepts	Neoplastic Somatotroph Cell
C45939	Neoplastic_Somatotroph_Cell_with_Abundant_Secretory_Granules	Neoplastic_Growth_Hormone_Cell	Neoplastic Somatotroph Cell with Abundant Secretory Granules
C45940	Neoplastic_Somatotroph_Cell_with_Scarce_Secretory_Granules	Neoplastic_Growth_Hormone_Cell	Neoplastic Somatotroph Cell with Scarce Secretory Granules
C45941	Malignant_Somatotroph_Cell	Malignant_Adenohypophysial_Cell|Neoplastic_Growth_Hormone_Cell	Malignant Somatotroph Cell
C45943	Corticotroph_Cell	Basophilic_Cell	Corticotroph Cell|Corticotroph	A small, irregularly stellate, acidophilic cell of the adenohypophysis, having small, sparsely distributed secretory granules and secreting adrenocorticotropic hormone and b-endorphin, which are cleaved from a large prohormone called pro-opiomelanocortin.
C45944	Malignant_Corticotroph_Cell	Malignant_Adenohypophysial_Cell|Neoplastic_Corticotroph_Cell	Malignant Corticotroph Cell
C45946	Glucose_Tolerance_Test	Diagnostic_Test	Glucose Tolerance Test	The Glucose Tolerance Test involves administration of a know quantity of glucose as a means of screening for glucose intolerance or diabetes mellitus. Typically a baseline (fasting plasma or serum glucose) is drawn prior to the administration of the glucose bolus.  Serial plasma glucose levels are obtained (e.g. 30min, 1hr, 2hr, 3hr) and a plot of plasma glucose versus time is created.  Comparison of these values against standardized results can be used in establishing the diagnosis of glucose intolerance or diabetes mellitus. (NCI2005)
C45947	Thyrotroph_Cell	Retired_Concepts	Thyrotroph Cell|Thyrotroph	A cell of the adenohypophysis that secretes thyrotropin.
C45948	Malignant_Thyrotroph_Cell	Malignant_Adenohypophysial_Cell|Neoplastic_Thyrotroph_Cell	Malignant Thyrotroph Cell
C45949	Lactotroph_Cell	Retired_Concepts	Lactotroph Cell|Lactotroph|Prolactin Cell	A cell of the anterior pituitary that produces and secretes prolactin.
C45950	Neoplastic_Lactotroph_Cell	Retired_Concepts	Neoplastic Lactotroph Cell|Neoplastic Prolactin Cell
C45951	Malignant_Lactotroph_Cell	Malignant_Adenohypophysial_Cell|Neoplastic_Prolactin_Cell	Malignant Lactotroph Cell|Malignant Prolactin Cell
C45952	Lactotroph_Cell_with_Large_Secretory_Granules	Neoplastic_Prolactin_Cell	Neoplastic Lactotroph Cell with Large Secretory Granules
C45953	Neoplastic_Lactotroph_Cell_with_Small_Secretory_Granules	Neoplastic_Prolactin_Cell	Neoplastic Lactotroph Cell with Small Secretory Granules
C45954	Misplaced_Exocytosis_Present	Ultrastructural_Finging	Misplaced Exocytosis Present
C45955	Well_Developed_Rough_Endoplasmic_Reticulum_Present	Ultrastructural_Finging	Well Developed Rough Endoplasmic Reticulum Present|Well Developed RER Present
C45956	Concentric_Aggregates_of_Intermediate_Filaments_Present	Ultrastructural_Finging	Concentric Aggregates of Intermediate Filaments Present
C45957	Precursor_Adenohypophysial_Cell	Adenohypophysial_Cell	Precursor Adenohypophysial Cell
C45958	Gonadotroph_Cell	Adenohypophysial_Cell	Gonadotroph Cell|Gonadotroph	An endocrine cell of the adenohypophysis that affects certain cells of the ovary or testis.
C45960	No_Evidence_of_Hormone_Immunoreactivity_Present	Negative_Test_Result	No Evidence of Hormonal Immunoreactivity Present|No Evidence of Hormone Immunoreactivity Present
C45961	Giant_Mitochondria_Present	Ultrastructural_Finging	Giant Mitochondria Present
C45962	Multihormonal_Immunoreactivity_Present	Positive_Immunophenotypic_Test_Result	Multihormonal Immunoreactivity Present
C45963	Neoplastic_Adenohypophysial_Cell	Neoplastic_Endocrine_Cell|Neoplastic_Glandular_Cell	Neoplastic Adenohypophysial Cell
C45964	Lesion_with_Diameter_of_10mm_or_Less	Lesion	Lesion with Diameter of 10mm or Less
C45965	Lesion_with_Diameter_Greater_than_10mm	Lesion	Lesion with Diameter Greater than 10mm
C45966	Subsite	Site	Subsite	A position within another named site.
C45967	Extensible_Markup_Language	Language	Extensible Markup Language|XML	Extensible Markup Language (XML) is a general-purpose markup language for creating special-purpose markup languages. It is capable of describing many different kinds of data. Its primary purpose is to facilitate the sharing of data across different systems, particularly systems connected via the Internet. (from Wikipedia)
C45968	Enteroendocrine_Cell	Endocrine_Cell_of_the_Gastrointestinal_System	Enteroendocrine Cell|Kulchitsky Cell	A hormone-secreting cell present in the epithelium of the intestine.
C45969	Binary_Value	Data_Type	Binary|Binary Value	Consisting of two (e.g., units, components, elements, terms, possibilities) or based on two.
C45970	Deidentification	Data_Processing	Deidentification	Removal of text elements that would make data individually identifiable.
C45971	Coding	Clinical_or_Research_Activity	Coding	The activity of implementing rules that are used to map the elements of one set onto the elements of another set, usually on a one-to-one basis. (from Wikipedia)
C45972	NCI_Metathesaurus_Code	Concept_Unique_Identifier	NCI Metathesaurus Code|Concept Code|Metathesaurus Code|Metathesaurus Concept Code|NCI Metathesaurus Concept Code	A concept unique identifier within the NCI Enterprise Vocabulary Service's NCI Metathesaurus.
C45973	Malignant_Adenohypophysial_Cell	Adenocarcinoma_Cell|Malignant_Endocrine_Cell|Neoplastic_Adenohypophysial_Cell	Malignant Adenohypophysial Cell
C45974	Computer_Programming_Object	Conceptual_Entities	Computer Programming Object|Object	In object-oriented programming, an object is a self-contained entity that consists of both data and procedures to manipulate the data. (pcwebopaedia.com)
C45976	XX_Genotype	Genotype	XX Genotype|46XX|Male Genotype|XX	The normal genotype of a female human.
C45977	XY_Genotype	Genotype	XY Genotype|46XY|Female Genotype|XY	The normal genotype of a male human.
C45978	Fungating_Mass	Mass	Fungating Mass
C45979	Lesion_Less_than_5mm_in_Diameter	Lesion_with_Diameter_of_10mm_or_Less	Lesion Less than 5mm in Diameter
C45980	Absence_of_a_Hormonal_Syndrome	Endocrine_System_Finding	Absence of a Hormonal Syndrome
C45981	Presence_of_a_Hormonal_Syndrome	Endocrine_System_Finding	Presence of a Hormonal Syndrome
C45982	Malignant_Neuroendocrine_Small_to_Intermediate_Size_Cell	Malignant_Neuroendocrine_Cell	Malignant Neuroendocrine Small to Intermediate Size Cell
C45983	Metastatic_Inhibitory_Effect	Biological_Process	Metastatic Inhibitory Effect
C45985	Bed_Rest	Treatment	Bed Rest|Bed Confinement|Confinement to Bed	Confinement of an individual to bed for therapeutic reasons.
C45986	FDA_UNII_Code_Property	NCI_Thesaurus_Property	FDA_UNII_Code	Contains the FDA Unique Ingredient Identifier, a key component of the new federal drug information model.
C45989	CYP2C19_6_Allele	CYP2C19_Gene	CYP2C19*6 Allele|CYP2C19*6|CYP2C19, R132Q|CYP2C19, c.395G>A|CYP2C19, m5|Cytochrome P450, Family 2, Subfamily C, Polypeptide 19*6 Allele	CYP2C19*6 allele is a variant form of the human CYP2C19 gene (cytochrome P450 family 2, subfamily C), located at 10q24.1-q24.3, which encodes the cytochrome P450 2C19 protein. This allele exhibits a clinically-relevant SNP (c.395G>A) in exon 3 that results in a R132Q coding change. This alteration in protein sequence abolishes the catalytic activity of the CYP2C19*6 enzyme.
C45991	Claus_Model	Computer_Program	Claus Model|Claus Breast Cancer Risk Assessment Model	The Claus model predicts the probability of a woman's risk for developing breast cancer based on her family history. It focuses solely on family history to estimate the probability that a woman will develop breast cancer. Using this model requires providing information about first-degree and second-degree relatives who have had breast cancer. It factors in the ages at which these relatives were diagnosed. It can also include breast cancer history on the father's side of the family as well. It's main advantage is its expanded inclusion of family history information. It is limited in that it can be used only with women who have at least one first- or second-degree relative with breast cancer. Also, it does not take into account other risk factors such as the presence of atypical hyperplasia, age of first menstrual period, or age of first live birth. (http://www.thinprep.com/women/women_breast_cancer_risk_methods.shtml)
C45992	Subtlety_Score	Disease_Modifier	Subtlety Score|Subtlety|Subtlety Rating	A subjective rating of the visibility of a lesion in a medical image, ranging from not visible to obvious.
C45993	Integrated_Molecular_Analysis_of_Genomes_and_their_Expression_Consortium	Professional_Organization_or_Group	Integrated Molecular Analysis of Genomes and their Expression Consortium|I.M.A.G.E.|I.M.A.G.E. Consortium|IMAGE|IMAGE Consortium	A group formed in 1993 by four academic groups on a collaborative basis after informal discussions led to a common vision of how to achieve an important goal in the study of the human genome: the Integrated Molecular Analysis of Genomes and their Expression. They share high-quality, arrayed cDNA libraries and place sequence, map, and expression data on the clones in these arrays into the public domain. The human and mouse genomes were the first to be studied, and the collection now contains clones from rat, zebrafish, Fugu, Xenopus and rhesus macaque. They anticipate arraying (and sharing) cDNA libraries from additional species over time. A majority of their clones are publicly available, free of any royalties, and may be used by anyone agreeing with their guidelines. (from http://image.llnl.gov/image/html/igoals.shtml)
C45994	Protein_Component	Miscellaneous_Molecular_Biology_Terms	Protein Component|Component|Functional Component|Protein Functional Component	A protein cleavage product with a demonstrated function.
C45995	Absorption	Physical_Phenomena_or_Properties	Absorption	The process in which incident radiated energy is retained without reflection or transmission on passing through a medium.
C45996	Dependency	Properties_or_Attributes	Dependency|Dependence	Related so that change in one leads to change in the other.
C45997	pH	Physical_Phenomena_or_Properties	pH|potential of Hydrogen	The logarithm of the reciprocal of hydrogen-ion concentration in gram atoms per lite, providing a measure, on a scale from 0 to 14, of the acidity or alkalinity of a solution where less than 7 is acidic, greater than 7 is basic, and 7 is neutral.
C45998	Oxidation-Reduction_Potential	Physical_Phenomena_or_Properties	Oxidation-Reduction Potential|Redox Potential	The potential developed by a metallic electrode when placed in a solution containing a species in two different oxidation states. (http://www.flw.com/define_r.htm)
C45999	Cytochrome-P450-3A5	Cytochrome-P450	Cytochrome P450 3A5
C46000	Cytochrome-P450-3A7	Cytochrome-P450	Cytochrome P450 3A7
C46001	Cytochrome-P450-2C8	Cytochrome-P450	Cytochrome P450 2C8
C46002	Key	UML_Entity	Key	A value used to identify a record in a database. (from Free On-Line Dictionary of Computing)
C46003	Difference	Properties_or_Attributes	Difference|Conflict|Different	The quality of being unlike or dissimilar.
C46004	Papillary_Thyroid_Gland_Microcarcinoma	Papillary_Thyroid_Carcinoma	Thyroid Gland Papillary Microcarcinoma|Papillary Microcarcinoma of the Thyroid|Papillary Microcarcinoma of the Thyroid Gland|Papillary Thyroid Gland Microcarcinoma|Papillary Thyroid Microcarcinoma	A papillary carcinoma of the thyroid gland measuring 10mm or less in diameter.  The survival rates of patients with this type of carcinoma are the same with those of the normal population. --2005
C46005	RET_PTC_Rearrangement	Clonal_Gene_Rearrangement	RET/PTC Rearrangement
C46006	TRK_Rearrangement	Clonal_Gene_Rearrangement	TRK Rearrangement
C46007	PPAR-gamma_Rearrangement	Clonal_Gene_Rearrangement	PPAR-gamma Rearrangement
C46008	Squamous_Cell_Thyroid_Gland_Carcinoma	Squamous_Cell_Carcinoma|Thyroid_Carcinoma	Thyroid Gland Squamous Cell Carcinoma|Squamous Cell Thyroid Gland Carcinoma	A rapidly growing primary carcinoma of the thyroid gland composed of malignant squamous cells.  The clinical course is usually aggressive. (NCI05)
C46009	CYP2C19_7_Allele	CYP2C19_Gene	CYP2C19*7 Allele|CYP2C19*7|CYP2C19, c.IVS5+2T>A|Cytochrome P450, Family 2, Subfamily C, Polypeptide 19*7 Allele	CYP2C19*7 allele is a variant form of the human CYP2C19 gene (cytochrome P450 family 2, subfamily C), located at 10q24.1-q24.3, which encodes the cytochrome P450 2C19 protein. This allele exhibits a clinically-relevant SNP (c.IVS5+2T>A) in the invariant GT at the 5' donor splice site of intron 5 that results in a splicing defect. This alteration abolishes the catalytic activity of the CYP2C19*7 enzyme.
C46010	CYP2C19_8_Allele	CYP2C19_Gene	CYP2C19*8 Allele|CYP2C19*8|CYP2C19, W120R|CYP2C19, c.358T>C|Cytochrome P450, Family 2, Subfamily C, Polypeptide 19*8 Allele	CYP2C19*8 allele is a variant form of the human CYP2C19 gene (cytochrome p450 family 2, subfamily C), located at 10q24.1-q24.3, which encodes the cytochrome P450 2C19 protein. This allele exhibits a clinically-relevant SNP (c.358T>C) in exon 3 that results in a W120R coding change. This alteration in protein sequence severely decreases the catalytic activity of the CYP2C19*8 enzyme.
C46011	CYP2C19_9_Allele	CYP2C19_Gene	CYP2C19*9 Allele|CYP2C19*9|CYP2C19, R144H|CYP2C19, c.431G>A|Cytochrome P450, Family 2, Subfamily C, Polypeptide 19*9 Allele	CYP2C19*9 allele is a variant form of the human CYP2C19 gene (cytochrome P450 family 2, subfamily C), located at 10q24.1-q24.3, which encodes the cytochrome P450 2C19 protein. This allele exhibits a clinically-relevant SNP (c.431G>A) in exon 3 that results in a R144H coding change. This alteration in protein sequence decreases the catalytic activity of the CYP2C19*9 enzyme.
C46012	CYP2C19_10_Allele	CYP2C19_Gene	CYP2C19*10 Allele|CYP2C19*10|CYP2C19, P227L|CYP2C19, c.680C>T|Cytochrome P450, Family 2, Subfamily C, Polypeptide 19*10 Allele	CYP2C19*10 allele is a variant form of the human CYP2C19 gene (cytochrome P450 subfamily 2C), located at 10q24.1-q24.3, which encodes the cytochrome P450 2C19 protein. This allele exhibits a clinically-relevant SNP (c.680C>T) in exon 5 that results in a P227L coding change. This alteration in protein sequence severely decreases the catalytic activity of the CYP2C19*10 enzyme.
C46013	CYP2C19_12_Allele	CYP2C19_Gene	CYP2C19*12 Allele|CYP2C19*12|CYP2C19, X491C|CYP2C19, c.1473A>C|Cytochrome P450, Family 2, Subfamily C, Polypeptide 19*12 Allele	CYP2C19*12 allele is a variant form of the human CYP2C19 gene (cytochrome P450 family 2, subfamily C), located at 10q24.1-q24.3, which encodes the cytochrome P450 2C19 protein. This allele exhibits a clinically-relevant SNP (c.1473A>C) in exon 9 that results in a X491C coding change. This alteration yields an unstable CYP2C19*12 protein that is predicted to have an additional 26 amino acids.
C46014	CYP2C9_6_Allele	CYP2C9_Gene	CYP2C9*6 Allele|CYP2C9*6|CYP2C9, c.818delA|Cytochrome P450, Family 2, Subfamily C, Polypeptide 9*6 Allele	CYP2C9*6 allele is a variant form of the human CYP2C9 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C9 protein. This allele exhibits a clinically-relevant SNP (c.818delA) in exon 5 that results in a coding frameshift. This alteration in protein sequence severely decreases the catalytic activity of the CYP2C9*6 enzyme.
C46015	CYP2C9_8_Allele	CYP2C9_Gene	CYP2C9*8 Allele|CYP2C9*8|CYP2C9, R150H|CYP2C9, c.449G>A|Cytochrome P450, Family 2, Subfamily C, Polypeptide 9*8 Allele	CYP2C9*8 allele is a variant form of the human CYP2C9 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C19 protein. This allele exhibits a clinically-relevant SNP (c.449G>A) in exon 3 that results in a R150H coding change. This alteration in protein sequence increases the catalytic activity of the CYP2C9*8 enzyme.
C46016	CYP2C9_11_Allele	CYP2C9_Gene	CYP2C9*11 Allele|CYP2C9*11|CYP2C9, R335W|CYP2C9, c.1003C>T|Cytochrome P450, Family 2, Subfamily C, Polypeptide 9*11 Allele	CYP2C9*11 allele is a variant form of the human CYP2C9 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C19 protein. This allele exhibits a clinically-relevant SNP (c.1003C>T) in exon 7 that results in a R335W coding change. This alteration in protein sequence severely decreases the catalytic activity of the CYP2C9*11 enzyme.
C46017	CYP2C9_12_Allele	CYP2C9_Gene	CYP2C9*12 Allele|CYP2C9*12|CYP2C9, P489S|CYP2C9, c.1465C>T|Cytochrome P450, Family 2, Subfamily C, Polypeptide 9*12 Allele	CYP2C9*12 allele is a variant form of the human CYP2C9 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C19 protein. This allele exhibits a clinically-relevant SNP (c.1465C>T) in exon 9 that results in a P489S coding change. This alteration in protein sequence decreases the catalytic activity of the CYP2C9*12 enzyme.
C46018	CYP2C9_16_Allele	CYP2C9_Gene	CYP2C9*16 Allele|CYP2C9*16|CYP2C9, T299A|CYP2C9, c.895A>G|Cytochrome P450, Family 2, Subfamily C, Polypeptide 9*16 Allele	CYP2C9*16 allele is a variant form of the human CYP2C9 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C19 protein. This allele exhibits a clinically-relevant SNP (c.895A>G) that results in a T299A coding change. This alteration in protein sequence decreases the in vivo catalytic activity of the CYP2C9*16 enzyme.
C46019	CYP2C9_18_Allele	CYP2C9_Gene	CYP2C9*18 Allele|CYP2C9*18|CYP2C9, D397A|CYP2C9, c.1190A>C|Cytochrome P450, Family 2, Subfamily C, Polypeptide 9*18 Allele	CYP2C9*18 allele is a variant form of the human CYP2C9 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C19 protein. This allele exhibits a clinically-relevant SNP (c.1190A>C) in exon 8 that results in a D397A coding change. The alteration in protein sequence decreases the in vivo catalytic activity of the CYP2C9*18 enzyme.
C46020	CYP3A7_2_Allele	CYP3A7_Gene	CYP3A7*2 Allele|CYP3A7*2|CYP3A7, T409R|CYP3A7, c.1226C>G|Cytochrome P450, Family 3, Subfamily A, Polypeptide7*2 Allele	CYP3A7*2 allele is a variant form of the human CYP3A7 gene (cytochrome P450 family 3, subfamily A), located at 7q22.1, which encodes the cytochrome P450 3A7 protein. This allele exhibits a clinically-relevant SNP (c.1226C>G) in exon 11 that results in a T409R coding change. This alteration in protein sequence increases the catalytic activity of the CYP3A7*2 enzyme.
C46021	CYP3A5_3_Allele	CYP3A5_Gene	CYP3A5*3 Allele|CYP3A5*3|CYP3A5, g.6986A>G|Cytochrome P450, Family 3, Subfamily A, Polypeptide 5*3 Allele	CYP3A5*3 allele is a variant form of the human CYP3A5 gene (cytochrome P450 family 3, subfamily A), located at 7q22.1, which encodes the cytochrome P450 3A5 protein. Although a number of individual cases of this variant allele have been identified, the clinically-significant mutation in all of these cases is a SNP (g.6986A>G) in intron 3 that results in a splicing defect and premature stop at 102 amino acids. This alteration severely decreases the catalytic activity of the CYP3A5*3 enzyme.
C46022	CYP3A5_6_Allele	CYP3A5_Gene	CYP3A5*6 Allele|CYP3A5*6|CYP3A5, g.14690G>A|Cytochrome P450, Family 3, Subfamily A, Polypeptide 5*6 Allele	CYP3A5*6 allele is a variant form of the human CYP3A5 gene (cytochrome P450 family 3, subfamily A), located at 7q22.1, which encodes the cytochrome P450 3A5 protein. This allele exhibits a clinically-relevant SNP (g.14690G>A), resulting in deletion of exon 7 from the splice variant, a frame shift and premature stop at 184 amino acids. Truncation of the CYP3A5*6 protein causes loss of enzymatic activity.
C46023	CYP3A5_8_Allele	CYP3A5_Gene	CYP3A5*8 Allele|CYP3A5*8|CYP3A5, R28C|CYP3A5, g.3699C>T|Cytochrome P450, Family 3, Subfamily A, Polypeptide 5*8 Allele	CYP3A5*8 allele is a variant form of the human CYP3A5 gene (cytochrome P450 family 3, subfamily A), located at 7q22.1, which encodes the cytochrome P450 3A5 protein. This allele exhibits a clinically-relevant SNP (g.3699C>T) in exon 2 that results in a R28C coding change. This alteration in protein sequence decreases the activity of the CYP3A5*8 enzyme.
C46024	CYP3A5_9_Allele	CYP3A5_Gene	CYP3A5*9 Allele|CYP3A5*9|CYP3A5, A337T|CYP3A5, g.19386G>A|Cytochrome P450, Family 3, Subfamily A, Polypeptide 5*9 Allele	CYP3A5*9 allele is a variant form of the human CYP3A5 gene (cytochrome P450 family 3, subfamily A), located at 7q22.1, which encodes the cytochrome P450 3A5 protein. This allele exhibits a clinically-relevant SNP (g.19386G>A) in exon 10 that results in an A337T coding change. This alteration in protein sequence decreases the catalytic activity of the CYP3A5*9 enzyme.
C46025	CYP3A5_10_Allele	CYP3A5_Gene	CYP3A5*10 Allele|CYP3A5*10|CYP3A5, g.6986A>G|Cytochrome P450, Family 3, Subfamily A, Polypeptide 5*10 Allele	CYP3A5*10 allele is a variant form of the human CYP3A5 gene (cytochrome P450 family 3, subfamily A), located at 7q22.1, which encodes the cytochrome P450 3A5 protein. This allele exhibits a clinically-relevant SNP (g.6986A>G) in exon 10 that causes a splicing defect. The resulting alteration in protein sequence almost completely abolishes the catalytic activity of the CYP3A5*10 enzyme.
C46026	CYP3A4_17_Allele	CYP3A4_Gene	CYP3A4*17 Allele|CYP3A4*17|CYP3A4, F189S|CYP3A4, g.15615T>C|Cytochrome P450, Family 3, Subfamily A, Polypeptide 4*17 Allele	CYP3A4*17 allele is a variant form of the human CYP3A4 gene (cytochrome P450 family 3, subfamily A), located at 7q22.1, which encodes the cytochrome P450 3A4 protein. This allele exhibits a clinically-relevant SNP (g.15615T>C) in exon 7 that results in a F189S coding change. This alteration in protein sequence severely decreases the catalytic activity of the CYP3A4*17 enzyme.
C46027	CYP3A4_18_Allele	CYP3A4_Gene	CYP3A4*18 Allele|CYP3A4*18|CYP3A4, L293P|CYP3A4, g.20070T>C|Cytochrome P450, Family 3, Subfamily A, Polypeptide 4*18 Allele	CYP3A4*18 allele is a variant form of the human CYP3A4 gene (cytochrome P450 family 3, subfamily A), located at 7q22.1, which encodes the cytochrome P450 3A4 protein. This allele exhibits a clinically-relevant SNP (g.20070T>C) in exon 10 that results in a L293P coding change. This alteration in protein sequence dramatically increases the catalytic activity of the CYP3A4*18 enzyme.
C46028	CYP2E1_1_Allele	CYP2E1_Gene	CYP2E1*1 Allele|CYP2E1*1|Cytochrome P450, Family 2, Subfamily E, Polypeptide 1*1 Allele	CYP2E1*1 allele is a variant form of the human CYP2E1 gene (cytochrome P450 family 2, subfamily E), located at 10q24.3-qter, which encodes the cytochrome P450 2E1 protein. This allele contains 6 to 8 repeats of cis-acting elements (each 42-60 bp long) in the 5'-flanking region of the gene. This repeat polymorphism results in increased catalytic activity in individuals who carry this allele. However, enhanced in vivo enzymatic activity is only detected after alcohol consumption or in obese individuals.
C46029	CYP2E1_2_Allele	CYP2E1_Gene	CYP2E1*2 Allele|CYP2E1*2|CYP2E1, R76H|CYP2E1, g.1132G>A|Cytochrome P450, Family 2, Subfamily E, Polypeptide 1*2 Allele	CYP2E1*2 allele is a variant form of the human CYP2E1 gene (cytochrome P450 family 2, subfamily E), located at 10q24.3-qter, which encodes the cytochrome P450 2E1 protein. This allele exhibits a clinically-relevant SNP (g.1132G>A) in exon 2 that results in a R76H coding change. This alteration in protein sequence severely decreases the catalytic activity of the CYP2E1*2 enzyme.
C46030	CYP2C8_2_Allele	CYP2C8_Gene	CYP2C8*2 Allele|CYP2C8*2|CYP2C8, I269F|CYP2C8, c.805A>T|Cytochrome P450, Family 2, Subfamily C, Polypeptide 8*2 Allele	CYP2C8*2 allele is a variant form of the human CYP2C8 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C8 protein. This allele exhibits a clinically-relevant SNP (c.805A>T) in exon 5 that results in an I269F coding change. This alteration in protein sequence increases the Km of the CYP2C8*2 enzyme for paclitaxel, thereby decreasing the clearance of this drug.
C46031	CYP2C8_3_Allele	CYP2C8_Gene	CYP2C8*3 Allele|CYP2C8*3|CYP2C8, R139K, K399R|CYP2C8, c.416G>A, c.1196A>G|Cytochrome P450, Family 2, Subfamily C, Polypeptide 8*3 Allele	CYP2C8*3 allele is a variant form of the human CYP2C8 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C8 protein. This allele exhibits clinically-relevant SNPs (c.416G>A, c.1196A>G) in exons 3 and 8 that result in coding changes (R139K, K399R). These alterations in protein sequence severely decrease the catalytic activity of the CYP2C8*3 enzyme.
C46032	CYP2C8_4_Allele	CYP2C8_Gene	CYP2C8*4 Allele|CYP2C8*4|CYP2C8, I264M|CYP2C8, c.792C>G|Cytochrome P450, Family 2, Subfamily C, Polypeptide 8*4 Allele	CYP2C8*4 allele is a variant form of the human CYP2C8 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C8 protein. This allele exhibits a SNP (c.792C>G) in exon 5 that results in an I264M coding change. This alteration in protein sequence has no significant effect on the catalytic activity of the CYP2C8*4 enzyme in individuals heterozygous for this allele.
C46033	CYP2C8_5_Allele	CYP2C8_Gene	CYP2C8*5 Allele|CYP2C8*5|CYP2C8, c.475delA|Cytochrome P450, Family 2, Subfamily C, Polypeptide 8*5 Allele	CYP2C8*5 allele is a variant form of the human CYP2C8 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C8 protein. This allele exhibits a clinically-relevant single nucleotide deletion (c.475delA), resulting in a coding frameshift that is predicted to cause amino acid alterations from codon 159 and an early stop codon at residue 477. The CYP2C8*5 enzyme is expected to be catalytically inactive since it lacks 64% of the protein coding structure, including the heme binding site and 5 out of 6 substrate recognition sites.
C46034	CYP2C8_6_Allele	CYP2C8_Gene	CYP2C8*6 Allele|CYP2C8*6|CYP2C8, G171S|CYP2C8, c.511G>A|Cytochrome P450, Family 2, Subfamily C, Polypeptide 8*6 Allele	CYP2C8*6 allele is a variant form of the human CYP2C8 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C8 protein. This allele exhibits a SNP (c.511G>A) in exon 4 that results in a G171S coding change. However, this alteration in protein sequence has no effect on the catalytic activity of the CYP2C8*6 enzyme.
C46035	CYP2C8_7_Allele	CYP2C8_Gene	CYP2C8*7 Allele|CYP2C8*7|CYP2C8, R186X|CYP2C8, c.556C>T|Cytochrome P450, Family 2, Subfamily C, Polypeptide 8*7 Allele	CYP2C8*7 allele is a variant form of the human CYP2C8 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C8 protein. This allele exhibits a clinically-relevant SNP (c.556C>T) in exon 4 that results in a R186X coding change. This alteration yields a truncated CYP2C8*7 enzyme that is catalytically inactive.
C46036	CYP2C8_8_Allele	CYP2C8_Gene	CYP2C8*8 Allele|CYP2C8*8|CYP2C8, R186G|CYP2C8, c.556C>G|Cytochrome P450, Family 2, Subfamily C, Polypeptide 8*8 Allele	CYP2C8*8 allele is a variant form of the human CYP2C8 gene (cytochrome P450 family 2, subfamily C), located at 10q24, which encodes the cytochrome P450 2C8 protein. This allele exhibits a clinically-relevant SNP (c.556C>G) in exon 4 that results in a R186G coding change. This alteration in protein sequence severely decreases the catalytic activity of the CYP2C8*8 enzyme.
C46037	CYP1A2_1_Allele	CYP1A2_Gene	CYP1A2*1 Allele|CYP1A2*1|CYP1A2, g.-3860G>A, g.-729C>T, g.-163C>A|CYP1A2, wild-type|Cytochrome P450, Family 1, Subfamily A, Polypeptide 2*1 Allele	CYP1A2*1 allele is a variant form of the human CYP1A2 gene (cytochrome P450 family 1, subfamily A), located at 15q22-qter, which encodes the cytochrome P450 1A2 protein. There are multiple haplotypes of this allele. Both CYP1A2*1C, which has a SNP (g.-3860G>A) in the 5' flanking region of the gene, and CYP1A2*1K, which has a SNP (g.-729C>T) in intron 1, yield enzymes that exhibit decreased in vivo catalytic activity. CYP1A2*1F exhibits a SNP (g.-163C>A) in intron 1 that has been linked with higher enzyme inducibility.
C46038	CYP1A2_7_Allele	CYP1A2_Gene	CYP1A2*7 Allele|CYP1A2*7|CYP1A2, g.3534G>A|Cytochrome P450, Family 1, Subfamily A, Polypeptide 2*7 Allele	CYP1A2*7 allele is a variant form of the human CYP1A2 gene (cytochrome P450 family 1, subfamily A), located at 15q22-qter, which encodes the cytochrome P450 1A2 protein. This allele exhibits a clinically-relevant SNP (g.3534G>A) in the 5' splice-site consensus sequence of intron 6 that is predicted to result in abnormal mRNA splicing. This alteration decreases the in vivo catalytic activity of the CYP1A2*7 enzyme.
C46039	CYP1A2_11_Allele	CYP1A2_Gene	CYP1A2*11 Allele|CYP1A2*11|CYP1A2, F186L|CYP1A2, g.558C>A|Cytochrome P450, Family 1, Subfamily A, Polypeptide 2*11 Allele	CYP1A2*11 allele is a variant form of the human CYP1A2 gene (cytochrome P450 family 1, subfamily A), located at 15q22-qter, which encodes the cytochrome P450 1A2 protein. This allele exhibits a clinically-relevant SNP (g.558C>A) in exon 2 that results in a F186L coding change. This alteration in protein sequence severely decreases the catalytic activity of the CYP1A2*11 enzyme.
C46040	CYP2D6_2_Allele	CYP2D6_Gene	CYP2D6*2 Allele|CYP2D6*2|CYP2D6, R296C, S486T|CYP2D6, g.2850C>T, g.4180G>C|CYP2D6L|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*2 Allele	CYP2D6*2 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. The majority of haplotypes of this allele exhibit SNPs (g.2850C>T; g.4180G>C) in exons 6 and 9 that result in R296C and S486T coding changes. These alterations in protein sequence have no significant effect on the catalytic activity of the CYP2D6*2 enzyme.
C46041	CYP2D6_3_Allele	CYP2D6_Gene	CYP2D6*3 Allele|CYP2D6*3|CYP2D6, g.2549delA|CYP2D6A|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*3 Allele	CYP2D6*3 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a single nucleotide deletion (g.2549A>del) that results in a frameshift during protein coding. This alteration abolishes the catalytic activity of the CYP2D6*3 enzyme.
C46042	CYP2D6_7_Allele	CYP2D6_Gene	CYP2D6*7 Allele|CYP2D6*7|CYP2D6, H324P|CYP2D6, g.2935A>C|CYP2D6E|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*7 Allele	CYP2D6*7 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a clinically-relevant SNP (g.2935A>C) that results in a H324P coding change. This alteration in amino acid sequence causes an alteration of the 3D protein structure in close vicinity to the active site that abolishes the catalytic activity of the CYP2D6*7 enzyme.
C46043	CYP2D6_9_Allele	CYP2D6_Gene	CYP2D6*9 Allele|CYP2D6*9|CYP2D6, K281del|CYP2D6, g.2613delAGA|CYP2D6C|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*9 Allele	CYP2D6*9 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a deletion of three nucleotides (g.2613delAGA) at the 3' end of exon 5 that results in a K281 deletion during coding. This alteration in protein sequence decreases the catalytic activity of the CYP2D6*9 enzyme.
C46044	CYP2D6_11_Allele	CYP2D6_Gene	CYP2D6*11 Allele|CYP2D6*11|CYP2D6, g.883G>C|CYP2D6F|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*11 Allele	CYP2D6*11 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a clinically-relevant SNP (g.883G>C) that eliminates the splice acceptor site of intron 1 and results in a premature stop codon. This alteration abolishes the catalytic activity of the CYP2D6*11 enzyme.
C46045	CYP2D6_12_Allele	CYP2D6_Gene	CYP2D6*12 Allele|CYP2D6*12|CYP2D6, G42R|CYP2D6, g.124G>A|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*12 Allele	CYP2D6*12 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a clinically-relevant SNP (g.124G>A) in exon 1 that results in a G42R coding change. This alteration in protein sequence abolishes the catalytic activity of the CYP2D6*12 enzyme.
C46046	CYP2D6_13_Allele	CYP2D6_Gene	CYP2D6*13 Allele|CYP2D6*13|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*13 Allele	CYP2D6*13 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele, resulting from large deletions (approximately 20 kb) in the CYP2D gene cluster, is a hybrid gene consisting of exon 1 of CYP2D7 and exons 2-9 of CYP2D6. The protein product of this chimeric gene is catalytically inactive due to an insertion in exon 1 which causes a reading frame shift and protein truncation.
C46047	CYP2D6_14_Allele	CYP2D6_Gene	CYP2D6*14 Allele|CYP2D6*14|CYP2D6, G169R|CYP2D6, g.1758G>A|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*14 Allele	CYP2D6*14 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a clinically-relevant SNP (g.1758G>A) that results in a G169R coding change. This alteration in protein sequence decreases the catalytic activity of the CYP2D6*14 enzyme.
C46048	CYP2D6_15_Allele	CYP2D6_Gene	CYP2D6*15 Allele|CYP2D6*15|CYP2D6, g.138insT|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*15 Allele	CYP2D6*15 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a single nucleotide insertion (g.138insT) in exon 1 that causes in a frameshift during coding. This alteration abolishes the catalytic activity of the resulting CYP2D6*15 enzyme.
C46049	CYP2D6_16_Allele	CYP2D6_Gene	CYP2D6*16 Allele|CYP2D6*16|CYP2D6D2|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*16 Allele	CYP2D6*16 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele, resulting from large deletions in the CYP2D gene cluster, is a hybrid gene consisting of exons 1-7 of CYP2D7P-related and exons 8-9 of CYP2D6. This chimeric gene encodes a catalytically inactive CYP2D6*16 enzyme.
C46050	CYP2D6_18_Allele	CYP2D6_Gene	CYP2D6*18 Allele|CYP2D6(J9)|CYP2D6*18|CYP2D6, g.4125insGTGCCCACT|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*18 Allele	CYP2D6*18 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a nine nucleotide insertion (g.4125insGTGCCCACT) in exon 9. This alteration increased the Km value of the CYP2D6*18 enzyme toward bufuralol, resulting in a decreased catalytic activity.
C46051	CYP2D6_19_Allele	CYP2D6_Gene	CYP2D6*19 Allele|CYP2D6*19|CYP2D6, g.2539delAACT|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*19 Allele	CYP2D6*19 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a four nucleotide deletion (g.2539delAACT) that results in a frameshift during protein coding. This alteration abolishes the catalytic activity of the CYP2D6*19 enzyme.
C46052	CYP2D6_20_Allele	CYP2D6_Gene	CYP2D6*20 Allele|CYP2D6*20|CYP2D6, g.1973insG|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*20 Allele	CYP2D6*20 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a single nucleotide insertion (g.1973insG) that results in a frameshift during protein coding. This alteration abolishes the catalytic activity of the CYP2D6*20 enzyme.
C46053	CYP2D6_21_Allele	CYP2D6_Gene	CYP2D6*21 Allele|CYP2D6*21|CYP2D6, g.2573insC|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*21 Allele	CYP2D6*21 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a single nucleotide insertion (g.2573insC) in exon 5 that results in a frameshift and generates a stop codon 17 bp downstream of the insertion site. This alteration abolishes the catalytic activity of the CYP2D6*21 enzyme.
C46054	CYP2D6_35X2_Allele	CYP2D6_Gene	CYP2D6*35X2 Allele|CYP2D6*35X2|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*35X2 Allele	CYP2D6*35X2 allele is an amplification variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits four SNPs (g.31G>A; g.1661G>C; g.2850C>T; g.4180G>C) that result in three coding changes (V11M; R296C; S486T). CYP2D6*35X2 allele has two copies of the CYP2D6*35 variant, and this duplication increases CYP2D6 enzymatic activity in subjects who carry this allele.
C46055	CYP2D6_36_Allele	CYP2D6_Gene	CYP2D6*36 Allele|CYP2D6*36|CYP2D6, P34S|CYP2D6, g.100C>T|CYP2D6Ch2|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*36 Allele	CYP2D6*36 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a clinically-relevant SNP (g.100C>T) that results in a P34S coding change. This alteration decreases the catalytic activity of the CYP2D6*36 enzyme.
C46056	CYP2D6_38_Allele	CYP2D6_Gene	CYP2D6*38 Allele|CYP2D6*38|CYP2D6, N2|CYP2D6, g.2587delGACT|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*38 Allele	CYP2D6*38 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a four nucleotide deletion (g.2587delGACT) that results in a frameshift during protein coding. This alteration abolishes the catalytic activity of the CYP2D6*38 enzyme.
C46057	CYP2D6_40_Allele	CYP2D6_Gene	CYP2D6*40 Allele|CYP2D6*40|CYP2D6, g.1863insTTTCGCCCCTTTCGCCCC|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*40 Allele	CYP2D6*40 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits an 18 nucleotide insertion (g.1863insTTTCGCCCCTTTCGCCCC) that abolishes the catalytic activity of the CYP2D6*40 enzyme.
C46058	CYP2D6_41_Allele	CYP2D6_Gene	CYP2D6*41 Allele|CYP2D6*41|CYP2D6, R296C, S486T|CYP2D6, g.2850C>T, g.4180G>C|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*41 Allele	CYP2D6*41 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits clinically-relevant SNPs (g.2850C>T; g.4180G>C) in exons 6 and 9 that result in R296C and S486T coding changes. These alterations in protein sequence decrease the catalytic activity of the CYP2D6*41 enzyme.
C46059	CYP2D6_42_Allele	CYP2D6_Gene	CYP2D6*42 Allele|CYP2D6*42|CYP2D6, g.3259insGT|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*42 Allele	CYP2D6*42 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a two nucleotide insertion (g.3259insGT) that results in a frameshift during protein coding. This alteration abolishes the catalytic activity of the CYP2D6*42 enzyme.
C46060	CYP2D6_44_Allele	CYP2D6_Gene	CYP2D6*44 Allele|CYP2D6*44|CYP2D6, g.2950G>C|Cytochrome P450, Family 2, Subfamily D, Polypeptide 6*44 Allele	CYP2D6*44 allele is a variant form of the human CYP2D6 gene (cytochrome P450 family 2, subfamily D), located at 22q13.1, which encodes the cytochrome P450 2D6 protein. This allele exhibits a clinically-relevant SNP (g.2950G>C) in the intron 6 donor splice junction that results in a splicing defect. This alteration abolishes the catalytic activity of the CYP2D6*44 enzyme.
C46061	TPMT_V2_Allele	TPMT_Gene	TPMT*V2 Allele|TPMT*V2|TPMT-V2	Human TPMT*V2 allele is a variant form of the TPMT Gene (TPMT Family), located at chromosome 6p22.3, which encodes Thiopurine S-Methyltransferase. Some TPMT alleles contain variable numbers of 17/18 bp tandem repeats (VNTR), within the GC-rich 5'-flanking TPMT promoter region that modulate the level of TPMT enzyme activity (to a smaller extent than ORF-based SNP effects). TPMT*V2 contains 2 VNTR. A decrease in gene expression is seen with increasing repeat numbers.
C46062	TPMT-3C_Allele	TPMT_Gene	TPMT*3C Allele|TPMT*3C|TPMT, TYR240CYS|TPMT-3C|TPMT: cA719G	One of five major TPMT alleles, the human TPMT*3C allele is a variant form of the TPMT Gene (TPMT gene family), located at chromosome 6p22.3, which encodes Thiopurine S-Methyltransferase. This allele contains a single nucleotide transition point mutation (719A>G) that results in a tyr240-to-cys (Y240C) coding change. This alteration decreases the catalytic activity of the TPMT enzyme.
C46063	TPMT-2_Allele	TPMT_Gene	TPMT*2 Allele|TPMT*2|TPMT, ALA80PRO|TPMT: cG238C	One of five major TPMT alleles, human TPMT*2 allele is a variant form of the TPMT Gene (TPMT gene family), located at chromosome 6p22.3, which encodes Thiopurine S-Methyltransferase. This allele contains a single nucleotide transversion point mutation (238G>C) that results in a ala80-to-pro (A80P) coding change. Despite a comparable level of TPMP*2 mRNA expression compared to the wild type allele, studies with subjects who exhibit this allele showed enhanced protein degradation that leads to a significant reduction in TPMT catalytic activity.
C46067	Presymptomatic_Cancer	Neoplasm_by_Special_Category	Presymptomatic Cancer	The state before the onset or development of clinical disease. Persons who have presymptomatic cancer already have developed the disease of cancer, which is in a pre-clinical state. 2005
C46068	Thyroid_Gland_Oncocytic_Neoplasm	Oncocytic_Neoplasm|Thyroid_Neoplasm	Thyroid Gland Oncocytic Neoplasm|Hurthle Cell Neoplasm|Hurthle Cell Tumor|Hurthle cell neoplasm|Thyroid Gland Hurthle Cell Neoplasm	(HER-tel cell) An uncommon type of thyroid tumor that can be benign or malignant.
C46069	Amsterdam_Criteria	Diagnostic_or_Prognostic_Factor	Amsterdam Criteria	The clinical criteria established to determine the risk and diagnosis of Hereditary Non-Polyposis Colorectal Cancer (HNPCC). The criterion are as follows: 2 cases of colorectal cancer where families are small (one under age 55) and 2 cases of colorectal cancer and 1 case of endometrial cancer, or other early onset cancer.
C46070	Contralateral_Prophylactic_Mastectomy	Mastectomy	Contralateral Prophylactic Mastectomy|CPM	Surgical breast removal of the opposing breast to prevent breast carcinoma. 2005
C46071	CYP2C8_Gene	Cytochrome_P450_Family_Gene	CYP2C8 Gene|CPC8|CYP2C8|Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 Gene|P450 MP-12/MP-20	Human CYP2C8 gene (cytochrome P450 family 2, subfamily C), located at 10q23.33, encodes the cytochrome P450 2C8 protein, a monooxygenase enzyme that catalyzes the metabolism of drugs and xenobiotics. Several alleles of this gene contribute to the poor metabolizer phenotype, which is characterized by the inability to use cytochrome P450-dependent metabolic pathways for drug elimination.
C46072	Bilateral_Prophylactic_Mastectomy	Mastectomy	Bilateral Prophylactic Mastectomy|BPM	Surgical breast removal of the opposing breast to prevent breast carcinoma. 2005
C46073	Unilateral_Breast_Carcinoma	Breast_Carcinoma	Unilateral Breast Carcinoma|Unilateral Breast Cancer	Breast carcinoma of one breast, or one side of the breast. 2005
C46074	CYP3A5_Gene	Cytochrome_P450_Family_Gene	CYP3A5 Gene|CYP3A5|Cytochrome P450, Family 3, Subfamily A, Polypeptide 5 Gene	Human CYP3A5 gene (cytochrome P450 family3, subfamily A), located at 7q22.1, encodes cytochrome P450 3A5, a monooxygenase enzyme that catalyzes the oxidation of fatty acids, steroids, drugs and xenobiotics. Some alleles of this gene contribute to the poor metabolizer phenotype, which is characterized by the inability to use cytochrome P450-dependent metabolic pathways for drug elimination.
C46077	CYP3A7_Gene	Cytochrome_P450_Family_Gene	CYP3A7 Gene|CYP3A7|Cytochrome P450, Family 3, Subfamily A, Polypeptide 7 Gene	Human CYP3A7 gene (cytochrome P450 family 3, subfamily A), located at 7q21-q22.1, encodes cytochrome P450 3A7, a monooxygenase enzyme that primarily catalyzes the hydroxylation of testosterone and dehydroepiandrosterone 3-sulfate. This enzyme is also involved in the metabolism of drugs and xenobiotics.
C46078	Endoscopic_Ultrasound	Diagnostic_Ultrasound	Endoscopic Ultrasound	An ultrasound administered by using a tube containing flexible fibre optic wires that allows for the analysis of tissues inside the body.  Ultrasound technology utilizes high frequency waves and their echoes to produce an image. 2005
C46079	Randomized_Controlled_Clinical_Trial	Clinical_Trial	Randomized Controlled Clinical Trial	A study in which the participants are assigned by chance to separate groups to evaluate treatments.  The study also includes a control group, which is undergoing the same rigors of the study with placebo treatment or standard treatment.  The trial can also be controlled by the addition of a test group to ensure there are no factors present to skew the results and by the inclusion of peer-review analysis by appropriate government officials. 2005
C46080	Nonestrogen-dependent_Cancer	Malignant_Neoplasm	Nonestrogen-dependent Cancer|Nonestrogen-dependent Carcinoma	Cancer that is not dependent upon the presence of estrogen for metastasis or growth. 2005
C46081	Leptin	Regulatory_Protein	Leptin	Human leptin (167 aa, ~16 kD) is encoded by the leptin gene (LEP).  Leptin is secreted by adipocytes and is involved in the regulation of body fat stores. 2005
C46082	Osteopontin	Extracellular_Matrix_Protein	Osteopontin	Human osteopontin ( 314 aa, ~32,000 kD) is a bone phosphoprotein that interacts with the extracellular matrix. Osteopontin exists in 4 isoforms, and is secreted by secretory phase ductal epithelium. Implicated in the pathogenesis of several cancers. 2005
C46083	Cognitive_Dysfunction	Psychiatric_Disorder	Cognitive Dysfunction	Interference or disruption of cognitive processes.  This term encompasses a large number of problems and issues associated with intellectual functioning and information processing. 2005
C46084	Memory_Dysfunction	Psychiatric_Disorder	Memory Dysfunction	Interference or disruption of memory processes. Memory dysfunction refers to the inability to store  and retrieve information. This term encompasses a large number of problems and issues associated with intellectual functioning. 2005
C46085	Circumferential_Resection_Margin	Surgical_Margin	Circumferential Resection Margin|CRM	The distance between the radial extent of the tumor and the surgical incision used to excise the tumor. This distance is measured microscopically. 2005
C46086	Cancer_Risk_Prevention_Model	Cancer_Model	Cancer Risk Prevention Model	Model systems that predict the occurrence of cancer in a population based on several parameters. These parameters serve as indicators of the predisposition for cancer development in populations or individuals. 2005
C46087	Contrast-enhanced_Magnetic_Resonance_Imaging	Magnetic_Resonance_Imaging	Contrast-enhanced Magnetic Resonance Imaging|Contrast-enhanced MRI	A technique that uses radiofrequency waves and a magnet to image the body.  The images are enhanced by the addition of contrast agents which selectively intensify anatomical regions to intensify the clarity of the image for diagnostic purposes. 2005
C46088	Caesarian_Section	Conventional_Surgery	Caesarian Section|C-Section	The delivery of an infant through a surgical abdominal incision.  Surgery is performed when there may be complications associated with a vaginal birth and increased risk to the mother or fetus. 2005
C46089	Allogeneic_Hematopoietic_Stem_Cell_Transplantation	Stem_Cell_Transplantation	Allogeneic Hematopoietic Stem Cell Transplantation|HSC|HSCT	A clinical treatment in which HSC capable of reconstituting the immune system and blood production (hematopoiesis) are transferred from one genetically dissimilar individual to another. The donor and recipient may or may not be related. 2005
C46090	Glycemic_Index	Diagnostic_Factor	Glycemic Index|GI	A ranking of the relationship between various foods and glucose blood serum levels. The carbohydrate composition of the food directly effects the concentration of glucose in the blood. 2005
C46091	Melanoma_Biomarker	Biomarker	Melanoma Biomarker	Skin cancer in melanocytes is termed melanoma, which is frequently centralized in a nevus or mole. A host of molecular proteins can be utilized as measurable phenotypic parameters to characterize or indicate the disease state of melanoma. 2005
C46092	Macrofollicular_Variant_Thyroid_Gland_Papillary_Carcinoma	Papillary_Thyroid_Carcinoma	Macrofollicular Variant Thyroid Gland Papillary Carcinoma|Macrofollicular_Variant_Thyroid_Gland_Papillary_Carcinoma	A morphologic variant of papillary carcinoma of the thyroid gland characterized by the predominance or the exclusive presence of macrofollicles.  Some of the malignant follicular cells display the nuclear characteristics that characterize the papillary adenocarcinomas of the thyroid gland. (NCI05)
C46093	Oncocytic_Variant_Thyroid_Gland_Papillary_Carcinoma	Papillary_Thyroid_Carcinoma|Thyroid_Gland_Oncocytic_Neoplasm	Oncocytic Variant Thyroid Gland Papillary Carcinoma	A morphologic variant of papillary carcinoma of the thyroid gland characterized by the presence of papillary or follicular structures, containing malignant follicular cells with abundant granular eosinophilic cytoplasm.  These cells have the nuclear features that characterize the papillary carcinomas of the thyroid gland. (NCI05)
C46094	Clear_Cell_Variant_Thyroid_Gland_Papillary_Carcinoma	Papillary_Thyroid_Carcinoma	Clear Cell Variant Thyroid Gland Papillary Carcinoma	A morphologic variant of papillary carcinoma of the thyroid gland characterized by the predominance of malignant follicular clear cells.  These cells have the nuclear features that characterize the papillary carcinomas of the thyroid gland. (NCI05)
C46095	Solid_Variant_Thyroid_Gland_Papillary_Carcinoma	Papillary_Thyroid_Carcinoma	Solid Variant Thyroid Gland Papillary Carcinoma	A morphologic variant of papillary carcinoma of the thyroid gland that predominantly affects children.  It is characterized by the presence of a solid growth pattern.  The malignant cells have nuclear features that are characteristic of papillary carcinomas of the thyroid gland. (NCI05)
C46096	Clear_Cell_Variant_Thyroid_Gland_Follicular_Carcinoma	Follicular_Thyroid_Carcinoma	Clear Cell Variant Thyroid Gland Follicular Carcinoma	A morphologic variant of follicular carcinoma of the thyroid gland characterized by the predominance of malignant follicular clear cells.  These cells lack the nuclear features that characterize the papillary carcinomas of the thyroid gland. (NCI05)
C46098	Sporadic_Thyroid_Gland_Medullary_Carcinoma	Medullary_Thyroid_Carcinoma	Sporadic Thyroid Gland Medullary Carcinoma	A non-hereditary medullary carcinoma of the thyroid gland not associated with multiple endocrine neoplasia.  The majority of thyroid gland medullary carcinomas are sporadic. (NCI05)
C46099	Hereditary_Thyroid_Gland_Medullary_Carcinoma	Familial_Cancer|Medullary_Thyroid_Carcinoma	Hereditary Thyroid Gland Medullary Carcinoma|Familiar Thyroid Gland Medullary Carcinoma	A medullary thyroid gland carcinoma inherited through an autosomal dominant mode.  It is associated with multiple endocrine neoplasia type II (2a) or III (2b). (NCI05)
C46100	C-Cell_Hyperplasia	Hyperplasia|Non-Neoplastic_Endocrine_Disorder|Thyroid_Gland_Disorder	C-Cell Hyperplasia
C46101	Neoplastic_C-Cell_Hyperplasia	Atypical_Hyperplasia|C-Cell_Hyperplasia|Thyroid_Neoplasm	Neoplastic C-Cell Hyperplasia	A neoplastic process arising from the C-cells of the thyroid gland.  It is considered a precursor of hereditary medullary thyroid gland carcinoma, and it is associated with mutations of the RET gene. (NCI05)
C46102	Reactive_C-Cell_Hyperplasia	C-Cell_Hyperplasia|Non-Neoplastic_Thyroid_Gland_Disorder	Reactive C-Cell Hyperplasia
C46103	Sporadic_Thyroid_Gland_Micromedullary_Carcinoma	Sporadic_Thyroid_Gland_Medullary_Carcinoma	Sporadic Thyroid Gland Micromedullary Carcinoma	A sporadic thyroid gland medullary carcinoma measuring less than 10mm in diameter.
C46104	Thyroid_Gland_Mixed_Medullary_and_Follicular_Cell_Carcinoma	Malignant_Endocrine_Neoplasm|Thyroid_Carcinoma	Thyroid Gland Mixed Medullary and Follicular Cell Carcinoma	A primary carcinoma of the thyroid gland containing a medullary carcinoma component that is immunohistochemically positive for calcitonin, and follicular cell carcinoma structures that are immunohistochemically positive for thyroglobulin. (NCI05)
C46105	Thyroid_Gland_Spindle_Cell_Tumor_with_Thymus-Like_Differentiation	Thyroid_Carcinoma	Thyroid Gland Spindle Cell Tumor with Thymus-Like Differentiation|SETTLE	A rare, slow growing, primary carcinoma of the thyroid gland characterized by a lobulated architectural pattern and the presence of a biphasic cellular population composed of spindle epithelial cells and glandular cells.  A small number of cases are composed exclusively of spindle epithelial cells or glandular cells.
C46106	Thyroid_Gland_Carcinoma_Showing_Thymus-Like_Differentiation	Thyroid_Carcinoma	Thyroid Gland Carcinoma Showing Thymus-Like Differentiation|CASTLE	A rare primary carcinoma of the thyroid gland, composed of groups of carcinoma cells, separated by a desmoplastic stroma.  The architectural pattern resembles the lobulation that is present in thymomas and thymic carcinomas. (NCI05)
C46107	Male_Self-Report	General_Modifier	Male, Self-Report|Male|Male, Self Report|Male, Self Reported	An individual who reports to be male, the sex that ordinarily produces sperm.
C46108	Female_Self-Report	General_Modifier	Female, Self-Report|Female|Female, Self Report|Female, Self Reported	An individual who reports to be female, the sex that ordinarily produces ova.
C46109	Male_Gender	General_Modifier	Male Gender|Male|Male Gender, Self Report|Male Gender, Self Reported	An individual who reports belonging to the cultural gender role distinction of male.
C46110	Female_Gender	General_Modifier	Female Gender|Female|Female Gender, Self Report|Female Gender, Self Reported	An individual who reports belonging to the cultural gender role distinction of female.
C46111	Thyroid_Gland_Follicular_Adenoma_with_Papillary_Hyperplasia	Thyroid_Adenoma	Thyroid Gland Follicular Adenoma with Papillary Hyperplasia|Papillary Variant Thyroid Gland Follicular Adenoma	A thyroid gland adenoma affecting predominantly children and adolescents.  It is composed of branching papillary structures and follicles. (NCI05)
C46112	Male_Phenotype	General_Modifier	Male Phenotype|Male	An animal who is observed by researcher or clinician to be male, the sex that ordinarily produces sperm.
C46113	Female_Phenotype	General_Modifier	Female Phenotype|Female	An animal who is observed by researcher or clinician to be female, the sex that ordinarily produces ova.
C46115	Thyroid_Gland_Signet_Ring_Cell_Follicular_Adenoma	Thyroid_Adenoma	Thyroid Gland Signet Ring Cell Follicular Adenoma|Thyroid Gland Signet-Ring Cell Follicular Adenoma	A thyroid gland adenoma characterized by the presence of signet ring cells that stain positive for thyroglobulin.  (NCI05)
C46116	Thyroid_Gland_Mucinous_Follicular_Adenoma	Thyroid_Adenoma	Thyroid Gland Mucinous Follicular Adenoma	A thyroid gland adenoma composed of follicles and characterized by the presence of abundant extracellular mucin. (NCI05)
C46117	Transsexual	General_Modifier	Transsexual	A person who was assigned to one gender at birth based on physical characteristics but who self-identifies psychologically and emotionally as the other.
C46118	Thyroid_Gland_Lipoadenoma	Lipoadenoma|Thyroid_Adenoma	Thyroid Gland Lipoadenoma	A thyroid gland adenoma composed of follicles and mature adipocytes.
C46119	Thyroid_Gland_Clear_Cell_Follicular_Adenoma	Thyroid_Adenoma	Thyroid Gland Clear Cell Follicular Adenoma	A thyroid gland adenoma composed of follicular cells with cytoplasmic clearing. (NCI05)
C46120	Male-to-Female_Transsexual	Transsexual	Male-to-Female Transsexual|M-to-F|M2F|MTF|Male-to-Female Transsexual, Self-Report	A person who was assigned to the male gender at birth based on physical characteristics but who self-identifies psychologically and emotionally as female.
C46121	Female-to-Male_Transsexual	Transsexual	Female-to-Male Transsexual|F-to-M|F2M|FTM|Female-to-Male Transsexual, Self-Report	A person who was assigned to the female gender at birth based on physical characteristics but who self-identifies psychologically and emotionally as male.
C46122	Thyroid_Gland_Toxic_Hyperfunctioning_Adenoma	Thyroid_Adenoma	Thyroid Gland Toxic (Hyperfunctioning) Adenoma	A thyroid gland adenoma producing thyroxin.  It is associated with hyperthyroidism.  Radioactive iodine scan reveals a hot nodule. (NCI05)
C46123	Thyroid_Gland_Follicular_Adenoma_with_Bizarre_Nuclei	Thyroid_Adenoma	Thyroid Gland Follicular Adenoma with Bizarre Nuclei	A thyroid gland adenoma containing follicular cells with large hyperchromatic nuclei.  The clinical course is benign. (NCI05)
C46124	Thyroid_Gland_Teratoma	Teratoma|Thyroid_Neoplasm	Thyroid Gland Teratoma	A mature or immature multicystic germ cell tumor involving or being in direct continuity with the thyroid gland.  Microscopically, many tissue types and growth patterns may be seen.  According to the presence of mature or immature tissue elements, these lesions are graded from I to IV.  The prognosis depends on the age of the patient, the tumor size at presentation, and the histologic grade. (NCI05)
C46125	Thyroid_Gland_Paraganglioma	Head_and_Neck_Paraganglioma|Thyroid_Neoplasm	Thyroid Gland Paraganglioma	A rare, circumscribed or encapsulated neuroendocrine tumor arising from the thyroid gland.  Microscopically, it is characterized by the presence of tumor cells arranged in a nesting (Zellballen) growth pattern.  The reported cases have followed a benign clinical course. (NCI05)
C46126	Ordinal_Number	Number	Ordinal Number|Ordinal|Ordinal Position Number	A number designating a place in an ordered sequence.
C46128	Capsular_Invasion	Morphologic_Finding	Capsular Invasion
C47380	Acetohexamide	Anti-diabetic_Agent	Acetohexamide|1-(p-Acetylbenzenesulfonyl)-3-Cyclohexylurea|3-Cyclohexyl-1-(p-acetylphenylsulfonyl)urea|4-Acetyl-N-((cyclohexylamino)carbonyl)benzenesulfonamide|ACETOHEXAMIDE|Cyclamide|Dimelin|Dymelor|N-(p-Acetylbenzenesulfonyl)-N'-cyclohexylurea|N-(p-Acetylphenylsulfonyl)-N'-cyclohexylurea	A sulfonylurea with oral hypoglycemic properties that is used in the treatment of Type II diabetes mellitus. Acetohexamide lowers blood sugar by stimulating insulin release from the pancreas and increases the sensitivity of beta cells to glucose stimulus. This drug also increases the sensitivity of insulin receptors in muscle, liver, and adipose tissue thereby promoting glucose transport across cell membranes. This results in better controlled blood glucose levels. (NCI05)
C47381	Acetohydroxamic_Acid	Enzyme_Inhibitor	Acetohydroxamic Acid|2-Hydroxyamino-2-ethanal|ACETOHYDROXAMIC ACID|AHA|Lithostat|N-Acetyl Hydroxyacetamide|N-Hydroxy-acetamide	A urea analogue with bacterial urease inhibiting activity. Acetohydroxamic acid is used as adjunctive therapy in the treatment of urinary tract infections caused by urease-producing bacteria. In addition, this drug is used in the prophylaxis and treatment of struvite renal calculi, whose formation is favored by urease-producing bacteria, by dissolving renal stones as well as preventing the formation of new crystals. (NCI05)
C47382	Acetylcholine_Chloride	Cholinergic_Agonist	Acetylcholine Chloride|2-Acetoxyethyltrimethylammonium Chloride|ACETYLCHOLINE CHLORIDE|ACH Chloride|Ethanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, Chloride|Miochol-E|Ovisot	A synthetic, quaternary amino alcohol with cholinergic properties. Acetylcholine chloride mimics the parasympathomimetic effect of the endogenous compound acetylcholine. Administered as an ophthalmic solution, this drug stimulates the cholinoceptors in the sphincter muscle of the iris, causing the pupil to constrict. (NCI05)
C47383	Acrivastine	Histamine-1_Receptor_Antagonist	Acrivastine|(E)-6-((E)-3-(1-Pyrrolidinyl)-1-p-tolylpropenyl)-2-pyridineacrylic Acid|2-Propenoic Acid, 3-(6-(1-(4-Methylphenyl)-3-(1-pyrrolidinyl)-1-propenyl)-2-pyridinyl)-,(E,E)-|ACRIVASTINE|BW 825C|Semprex	A synthetic alkylamine with non-sedative antihistaminergic activity. Acrivastine competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of gastrointestinal smooth muscle, caused by actions of histamine on bronchial, and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes. (NCI05)
C47384	Albendazole	Antihelminthic_Agent	Albendazole|ALBENDAZOLE|Albenza|Bilutac|Carbamic Acid,(5-(Propylthio)-1H-benzimidazol-2-yl)-, Methyl Ester|Proftril|SKF 62979|Zentel	A broad-spectrum, synthetic benzimidazole-derivative anthelmintic. Albendazole interferes with the reproduction and survival of helminths by inhibiting the formation of microtubules from tubulin. This leads to an impaired uptake of glucose, a depletion of glycogen stores, and results in the worm's death. Albendazole is used in the treatment of dog and pork tapeworm-causing diseases, including hydatid disease and neurocysticercosis. Albendazole may also be used to treat a variety of other roundworm infections. (NCI05)
C47385	Alclometasone_Dipropionate	Therapeutic_Glucocorticoid	Alclometasone Dipropionate|(7alpha,11beta,16alpha)-7-Chloro-11-hydroxy-16-methyl-17,21-bis(1-oxopropoxy)pregna-1,4-diene-3,20-dione|7a-Chloro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione-17,21-dipropionate|ALCLOMETASONE DIPROPIONATE|Aclovate|BRN 2317658|Delonal|Vaderm	A synthetic corticosteroid with low to medium potency. Alclometasone dipropionate is a glucocorticoid receptor agonist that mimics the metabolic, anti-inflammatory, immunosuppressive, antipruritic, and vasoconstrictive effects of natural glucocorticoids. This drug interacts with specific intracellular receptors and binds to DNA to modify gene expression. This results in an induction of synthesis of certain proteins while inhibiting the synthesis of others. Alclometasone dipropionate is used for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. (NCI05)
C47386	Alosetron_Hydrochloride	Antidiarrheal_Agent	Alosetron Hydrochloride|1H-Pyrido(4,3-b)indol-1-one, 2,3,4,5-tetrahydro-5-methyl-2((5-methyl-1H-imidazol-4-yl)methyl)-, Monohydrochloride|2,3,4,5-Tetrahydro-5-methyl-2-((5-methylimidazol-4-yl)methyl)-1H-pyrido(4,3-b)indol-1-one Monohydrochloride|ALOSETRON HYDROCHLORIDE|Lotronex	A potent and selective 5-HT3 receptor antagonist. Alosetron hydrochloride blocks the actions of serotonin at 5-HT3 sites in the peripheral nervous system, particularly on enteric and nociceptive sensory neurons. Alosteron hydrochloride affects the regulation of visceral pain, decreases gastrointestinal contraction and motility, and decreases gastrointestinal secretions. This drug is used to treat diarrhea-predominant irritable bowel syndrome in women. (NCI05)
C47387	Aluminum_Acetate	Topical_Anti-Infective_Agent	Aluminum Acetate|ALUMINUM ACETATE|Hydroxyaluminium Di(acetate)	A topical astringent that is used as an antiseptic agent. Aluminum acetate is used to treat inflammation, itching, and stinging of the infected skin and promotes healing.
C47388	Ambenonium_Chloride	Acetylcholinesterase_Inhibitor	Ambenonium Chloride|AMBENONIUM CHLORIDE|Ammonium,(Oxalylbis(iminoethylene))bis((o-chlorobenzyl)diethyl-, Dichloride|Benzenemethanaminium, N,N'-((1,2-Dioxo-1,2-ethanediyl)bis(imino-2,1-ethanediyl))bis(2-chloro-N,N-diethyl-, Dichloride|Misuran|Mytelase|Oxazyl|Win 8077	A quaternary ammonium compound with parasympathomimetic activity. Ambenonium chloride is an indirect-acting cholinergic agonist that blocks the activity of acetylcholinesterase, thereby enhancing cholinergic receptor stimulation by acetylcholine. This drug is particularly used to treat muscle weakness in patients with myasthenia gravis by enhancing acetylcholine activity on nicotinic receptors at the neuromuscular junction.
C47389	Amcinonide	Therapeutic_Glucocorticoid	Amcinonide|1,4-Pregnadiene-2,20-dione-16,17-cyclopentylidenedioxy-9-fluoro-11,21-dihydroxy-21-acetate|AMCINONIDE|CL 34699|Cyclocort|Triamcinolonacetatcyclopentanonid|Visderm	A synthetic glucocorticoid receptor agonist that mimics the metabolic, anti-inflammatory, and immunosuppressive activity of the natural glucocorticoids. Amcinonide interacts with specific corticosteroid receptors and was internalized, which leads to binding of DNA and modification of gene expression. This results in synthesis of anti-inflammatory mediators while inhibiting synthesis of inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are achieved.
C47390	Amiloride_Hydrochloride	Diuretic	Amiloride Hydrochloride|AMILORIDE HYDROCHLORIDE|CCRIS 5959|Midamor|N-Amidino-3,5-diamino-6-chloropyrazinecarboxamide Monohydrochloride|Pyrazinecarboxamide, N-Amidino-3,5-diamino-6-chloro-, Monohydrochloride	A synthetic pyrazine derivative. Amiloride hydrochloride is a potassium-sparing diuretic that acts directly on the late distal tubule and collecting duct by blocking sodium channels, thereby disrupting sodium exchange with potassium and hydrogen, and decreasing the driving force for secretion of potassium and hydrogen. The net effect is an increase of sodium and water excretion without removing potassium. Amiloride hydrochloride is used in the treatment of hypertension, congestive heart failure, hyperaldosteronism, nephrotic syndrome, and hepatic cirrhosis.
C47391	Aminocaproic_Acid	Miscellaneous_Adjuvant	Aminocaproic Acid|6-Aminocaproic Acid|6-Aminohexanoic Acid|AMINOCAPROIC ACID|Amicar|Cyklokapron|Epsilon S	A synthetic lysine derivative with antifibrinolytic activity. Aminocaproic acid competitively inhibits activation of plasminogen, thereby reducing conversion of plasminogen to plasmin (fibrinolysin), an enzyme that degrades fibrin clots as well as fibrinogen and other plasma proteins including the procoagulant factors V and VIII. Aminocaproic acid competitively reduces the conversion of plasminogen to plasmin by plasminogen activators. It directly inhibits proteolytic activity of plasmin, but higher doses are required than are needed to reduce plasmin formation. Aminocaproic acid is used in the treatment of hemorrhage and prophylactically against hemorrhage, including hyperfibrinolysis-induced hemorrhage and postsurgical hemorrhage.
C47392	Aminohippurate_Sodium	Diagnostic_Reagent	Aminohippurate Sodium|AMINOHIPPURATE SODIUM|Glycine, N-(4-Aminobenzoyl)-, Monosodium Salt|p-Aminohippuric Acid Sodium Salt	Sodium salt of aminohippuric acid. Aminohippurate sodium is used as a non-toxic diagnostic tool to measure effective renal plasma flow. At low plasma concentration this agent is filtered by the glomeruli and almost completely cleared from the renal blood stream by active tubular secretion in a single transit through the kidney. Its clearance corresponds to the renal plasma blood flow. Aminohippurate sodium is also used to measure functional capacity of the renal tubular secretory mechanism. This is achieved by elevating the drug plasma concentration to levels sufficient to saturate the maximal secretion capacity of the tubular cells.
C47393	Aminophylline	Bronchodilator	Aminophylline|1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compound with 1,2-Ethanediamine(2:1)|AMINOPHYLLINE|Ammophyllin|Phyllocontin|Theophyline Ethylenediamine|Truphylline	A methylxanthine and derivative of theophylline. Aminophylline relaxes smooth muscles, particularly bronchial muscles. This xanthine most likely exerts its effect by inhibiting cAMP or cGMP phosphodiesterases, thereby increasing levels of the second messenger cAMP or cGMP intracellularly. Other mode of actions include an adenosine antagonistic effect on the activity of CD4 lymphocytes and mediator release from mast cells thereby decreasing lung sensitivity to allergens and other substances that cause inflammation. Aminophylline also acts as a CNS stimulant and exerts a positive chronotropic and inotropic effect on the heart.
C47394	Aminosalicylic_Acid	Antitubercular_Agent	Aminosalicylic Acid|4-Aminosalicylic Acid|AMINOSALICYLIC ACID|Benzoic Acid, 4-Amino-2-hydroxy-|NIH 2939|Pamisyl|Paser|p-Aminosalicylic Acid
C47395	Amlexanox	Topical_Anti-Infective_Agent	Amlexanox|5H-(1)Benzopyrano(2,3-b)pyridine-3-carboxylic Acid, 2-Amino-7-(1-methylethyl)-5-oxo-|AMLEXANOX|Aphthasol	An anti-aphthous ulcer drug. Amlexanox inhibits the synthesis and release of inflammatory mediators, including leukotrienes and histamine, from mast cells, neutrophils, and mononuclear cells. Amlexanox also acts as a leukotriene D4 antagonist and a phosphodiesterase inhibitor. Amlexanox decreases the time ulcers take to heal as well as the pain associated with the ulcers.
C47396	Ammonium_Chloride	Expectorant	Ammonium Chloride|AMMONIUM CHLORIDE|Amchlor|Ammonium Muriate|Sal Ammoniac|Salammonite|Salmiac	A systemic and urinary acidifying salt. Ammonium chloride helps maintain pH and exerts a mild diuretic effect. This acid forming salt also exerts an expectorant effect by irritating the mucous membranes and is used for alleviation of cough.
C47397	Amoxapine	Antidepressant_Agent	Amoxapine|AMOXAPINE|Asendin|Demolox|Dibenz(b,f)(1,4)oxazepine, 2-Chloro-11-(1-piperazinyl)-	A tricyclic antidepressant of the dibenzoxazepine class. Amoxapine exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopamine. This drug is used to treat symptoms of depression and may cause tardive dyskinesia. Amoxapine also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which accounts for many of the side effects seen with this agent.
C47398	Anisindione	Anticoagulant_Agent	Anisindione|1,3-Indandione, 2-(p-methoxyphenyl)-|2-p-Anisyl-1,3-indandione|ANISINDIONE|Coumadin|Miradon|Unidone|Warfilone	A synthetic indanedione anticoagulant. Anisindione interferes with the vitamin K-dependent hepatic synthesis of active clotting factors by inhibiting the reduction of vitamin K. This leads to an inhibition of gamma-carboxylation of glutamic acid residues to gamma-carboxyglutamic acid in clotting factors II, VII, IX and X. The consequential effects of this inhibition include a reduced activity of these clotting factors and prolonged blood clotting time.
C47399	Antazoline_Phosphate	Histamine-1_Receptor_Antagonist	Antazoline Phosphate|1H-Imidazole-2-methanamine, 4,5-Dihydro-N-phenyl-N-(phenylmethyl)-, Phosphate(1:1)|2-((N-Benzylanilino)methyl)-2-imidazoline Phosphate(1:1)|ANTAZOLINE PHOSPHATE|EINECS 205-831-4|N-Benzyl-4,5-dihydro-N-phenyl-1H-imidazole-2-methylamine Monophosphate|Vasocon-A	An ethylenediamine derivative with histamine H1 antagonistic and sedative properties. Antazoline phosphate blocks the H1 histamine receptor and prevents the typical allergic symptoms that are caused by histamine activity on capillaries, skin, mucous membranes, gastrointestinal and bronchial smooth muscles. The histamine activities include vasodilation, bronchoconstriction, increased vascular permeability, pain, itching, and spasmodic contractions of gastrointestinal smooth muscles. Antazoline phosphate is used to provide symptomatic relieve of allergic symptoms.
C47400	Apomorphine_Hydrochloride	Antiparkinsonian_Agent	Apomorphine Hydrochloride|4H-Dibenzo(de,g)quinoline-10,11-diol, 5,6,6a,7-Tetrahydro-6-methyl-, Hydrochloride,(6aR)-|6ab-Aporphine-10,11-diol Hydrochloride Hemihydrate|APOMORPHINE HYDROCHLORIDE|Apokyn|N-Methylnorapomorphine Hydrochloride|Uprima	A derivative of morphine and non-ergoline dopamine agonist with high selectivity for dopamine D2, D3, D4 and D5 receptors. Apomorphine hydrochloride acts by stimulating dopamine receptors in the nigrostriatal system, hypothalamus, limbic system, pituitary gland, and blood vessels. This enhances motor function, suppresses prolactin release, and causes vasodilation and behavioral effects. Apomorphine hydrochloride is used in the treatment of Parkinson's disease and erectile dysfunction. In addition, apomorphine hydrochloride acts on the chemoreceptor trigger zone and is used as a central emetic in the treatment of drug overdose.
C47401	Apraclonidine_Hydrochloride	Alpha-adrenergic_Agonist	Apraclonidine Hydrochloride|1,4-Benzenediamine, 2,6-Dichloro-N(sup 1)-(4,5-dihydro-1H-imidazol-2-yl), Monohydrochloride|APRACLONIDINE HYDROCHLORIDE|Iopidine|p-Aminoclonidine Hydrochloride	A clonidine derivative with selective alpha2-adrenergic agonistic property. Apraclonidine hydrochloride enhances aqueous humor outflow and decreases aqueous production by vasoconstriction. It is used mostly in ophthalmic preparations for decreasing intraocular pressure.
C47402	Aprotinin_Bovine	Protease_Inhibitor	Aprotinin Bovine|APROTININ BOVINE|Trasylol	A single chain polypeptide from bovine lung with antifibrinolytic activity. Aprotinin bovine is a serine protease inhibitor and competitively and reversibly inhibits the activity of a number of different esterases and proteases, including trypsin, chymotrypsin, kallikrein, plasmin, tissue plasminogen activator, tissue and leukocytic proteinases. This drug is used intravenously to reduce bleeding and the need for transfusions during surgery. (NCI05)
C47403	Aripiprazole	Antipsychotic_Agent	Aripiprazole|2(1H)-Quinolinone, 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-|ARIPIPRAZOLE|Abilify|Opc 14597	A quinoline derivate and atypical anti-psychotic agent. Aripiprazole has partial agonistic activity at dopamine D2 receptors and serotonin 5-HT1A receptors, as well as potent antagonistic activity on serotonin 5-HT2A receptors. This drug stabilizes dopamine and serotonin activity in the limbic and cortical system. Aripiprazole is used in the treatment of positive and negative symptoms of schizophrenia and of acute manic and mixed episodes associated with bipolar I disorders.
C47404	Articaine_Hydrochloride	Anesthetic_Agent	Articaine Hydrochloride|2-Thiophenecarboxylic Acid, 4-Methyl-3-((1-oxo-2-(propylamino)propyl)amino)-, Methyl Ester, Monohydrochloride|4-Methyl-3-(2-(propylamino)propionamido)-2-thiophenecarboxylic Acid Methyl Ester HCl|ARTICAINE HYDROCHLORIDE|Septanest|Septocaine|Ultracaine	An amide-type local anesthetic. Articaine hydrochloride reversibly blocks nerve impulse conduction by binding to specific membrane sodium ion channels thereby interfering with the electrical excitation in the nerve, slowing the propagation of the nerve impulse and reducing the rate of rise of the action potential. This results in a loss of sensation at the injection site. Articaine hydrochloride is used for relief of pain in minor operations, usually in combination with the vasoconstrictor epinephrine.
C47405	Atomoxetine_Hydrochloride	Adrenergic_Agent	Atomoxetine Hydrochloride|(-)-N -Methyl-3-phenyl-3-(o-tolyloxy)-propylamine Hydrochloride|(-)-N-methyl-gamma(2-methylphenoxy)benzenepropamine Hydrochloride|ATOMOXETINE HYDROCHLORIDE|Strattera|Tomoxetine	A selective non-stimulant, norepinephrine reuptake inhibitor. Atomoxetine hydrochloride selectively inhibits the presynaptic reabsorption of norepinephrine, with minimal effect on other noradrenergic receptors or neurotransmitter transporters. Norepinephrine improves cognitive functioning, is secreted in the locus ceruleus, and released into the prefrontal cortex.  The action of atomoxetine hydrochloride prolongs the activity of norepinephrine in the synaptic cleft. Therefore, it is used in conjunction with norepinephrine in the symptomatic treatment of attention-deficit hyperactivity disorder.
C47406	Avobenzone	Sunscreen	Avobenzone|1-(4-(1,1-Dimethylethyl)phenyl)-3-(4-methoxyphenyl)-1,3-propanedione|1-(p-tert-Butylphenyl)-3-(p-methoxyphenyl)-1,3-propanedione|AVOBENZONE|Butyl Methoxydibenzoylmethane|Parsol 1789|Shade UVAguard	A sunscreen blocker. Avobenzone is a topical, broad range UV protector and blocks UVA I, UVA II, and UVB wavelengths, thereby limiting the impact of UV rays on skin. (NCI05)
C47407	Azelaic_Acid	Topical_Anti-Infective_Agent	Azelaic Acid|1,9-Nonanedioic Acid|AZELAIC ACID|Azelex|Finacea|Heptanedicarboxylic Acid|Lepargylic Acid|ZK 62498	A naturally occurring dicarboxylic acid produced by Malassezia furfur andfound in whole grain cereals, rye, barley and animal products.  Azelaic acid possesses antibacterial, keratolytic, comedolytic, and anti-oxidant activity. Azelaic acid is bactericidal against Proprionibacterium acnes and Staphylococcus epidermidis due to its inhibitory effect on the synthesis of microbial cellular proteins. Azelaic acid exerts its keratolytic and comedolytic effects by reducing the thickness of the stratum corneum and decreasing the number of keratohyalin granules by reducing the amount and distribution of filaggrin in epidermal layers. Azelaic acid also possesses a direct anti-inflammatory effect due to its scavenger activity of free oxygen radical. This drug is used topically to reduce inflammation associated with acne and rosacea.
C47408	Azelastine_Hydrochloride	Histamine-1_Receptor_Antagonist	Azelastine Hydrochloride|1(2H)-Phthalazinone, 4-((4-Chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, Monohydrochloride|AZELASTINE HYDROCHLORIDE|Astelin|Optivar|W-2979M
C47409	Balsalazide_Disodium	Anti-Infective_Agent	Balsalazide Disodium|BALSALAZIDE DISODIUM|Benzoic Acid, 5-((1E)-(4-(((2-Carboxyethyl)amino)carbonyl)phenyl)azo)-2-hydroxy-, Disodium Salt|Colazal	An aminosalicylate and oral prodrug that is enzymatically cleaved in the colon to produce the anti-inflammatory agent mesalazine. Mesalazine acts locally on the mucosa of the colon where it diminishes inflammation by blocking the production of arachidonic acid metabolites, including leukotriens, prostaglandins and hydroxyeicosatetraenoic acids, and other inflammatory agents. Balsalazide disodium is used to treat chronic inflammatory bowel disease.
C47410	Bendroflumethiazide	Diuretic	Bendroflumethiazide|2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-Dihydro-3-(phenylmethyl)-6-(trifluoromethyl)-, 1,1-Dioxide|BENDROFLUMETHIAZIDE|Naturetin	A thiazide diuretic. Bendroflumethiazide directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment of the distal convoluted tubule in the kidney. This drug increases water, sodium, chloride, potassium and bicarbonate excretion and decreases calcium and uric acid secretion. Bendroflumethiazide is commonly used to treat hypertension, edema, and congestive heart failure.
C47411	Benzoyl_Peroxide	Topical_Anti-Infective_Agent	Benzoyl Peroxide|Acnegel|BENZOYL PEROXIDE|Benoxyl	A peroxide with antibacterial, irritant, keratolytic, comedolytic, and anti-inflammatory activity. Upon topical application, benzoyl peroxide decomposes to release oxygen which is lethal to the bacteria Proprionibacterium acnes. Due to its irritant effect, benzoyl peroxide increases turnover rate of epithelial cells, thereby peeling the skin and promoting the resolution of comedones. Benzoyl peroxide is used in the treatment of acne vulgaris.
C47412	Bepridil_Hydrochloride	Calcium_Channel_Blocker	Bepridil Hydrochloride|1-Pyrrolidineethanamine, beta-((2-Methylpropoxy)methyl)-N-phenyl-N-(phenylmethyl)-, Monohydrochloride|BEPRIDIL HYDROCHLORIDE|Cordium|Vascor	A calcium antagonist and class IV anti-arrhythmic agent. Bepridil hydrochloride blocks calcium entry through membranous calcium channels of coronary and peripheral vascular smooth muscle, thereby dilating coronary arteries and peripheral arterioles. This increases oxygen delivery and reduces oxygen requirements. This drug is used to treat chronic stable and variant angina pectoris.
C47413	Betaxolol_Hydrochloride	Beta-Adrenergic_Blocking_Agent	Betaxolol Hydrochloride|1-(Isopropylamino)-3-(4-(2-(cyclopropylmethoxy)ethyl)phenoxy)propan-2-ol Hydrochloride|BETAXOLOL HYDROCHLORIDE|Betoptic|Kerlone	A beta-1-selective adrenergic receptor antagonist without intrinsic sympathomimetic activity. Betaxolol hydrochloride acts on the heart and circulatory system and decreases cardiac contractility and rate, thereby reducing cardiac output. When applied topically in the eye, it lowers intraocular pressure by reducing aqueous humor secretion.
C47414	Bimatoprost	Anti-glaucoma_Agent	Bimatoprost|5-Heptenamide, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3S)-3-hydroxy-5-phenyl-1-pentenyl)cyclopentyl)-N-ethyl-,(5Z)-|AGN 192024|BIMATOPROST|Lumigan	A synthetic prostamide and structural prostaglandin analogue with ocular hypotensive activity. Bimatoprost mimics the effects of the endogenous prostamides and reduces intracocular pressure by increasing outflow of aqueous humor through both the pressure-sensitive outflow pathway (the trabecular meshwork), and the pressure-insensitive outflow pathway (the uveoscleral routes).  It is not clear whether bimatoprost lowers intraocular pressure by stimulating F-Prostanoid receptors or by acting on specific prostamide receptors.
C47415	Bivalirudin	Anticoagulant_Agent	Bivalirudin|Angiomax|BIVALIRUDIN|Hirulog|L-Leucine, D-phenylalanyl-L-prolyl-L-arginyl-L-prolylglycylglycylglycylglycyl-L-asparaginylglycyl-L-alpha-aspartyl-L-phenylalanyl-L-alpha-glutamyl-L-alpha-glutamyl-L-isoleucyl-L-prolyl-L-alpha-glutamyl-L-alpha-glutamyl-L-tyrosyl-	A 20 amino acid long synthetic peptide with thrombin-specific anticoagulant properties. Bivalirudin reversibly binds thrombin, free as well as clot bound, at the catalytic site and the anion-binding exosite, thereby preventing the formation and activation of fibrin, factor XIIIa, and other coagulation factors. This drug is primarily used during coronary angioplasty procedures, in combination with aspirin, in patients with unstable angina.
C47416	Boric_Acid	Topical_Anti-Infective_Agent	Boric Acid|BORIC ACID|Orthoboric Acid	A weakly acidic hydrate of boric oxide with mild antiseptic, antifungal, and antiviral properties.  The exact mechanism of action of boric acid is unknown; generally cytotoxic to all cells.  It is used in the treatment of yeast infections and cold sores.
C47417	Bosentan	Antihypertensive_Agent	Bosentan|4-(1,1-Dimethylethyl)-N-(6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-(2,2'-bipyrimidin)-4-yl)benzenesulfornamide|BOSENTAN|Ro 47-0203|Tracleer	A sulfonamide-derived, competitive and specific endothelin receptor antagonist with a slightly higher affinity for the endothelin A receptor than endothelin B receptor. Bosentan blocks the action of endothelin 1, an extremely potent endogenous vasoconstrictor and bronchoconstrictor, by binding to endothelin A and endothelin B receptors in the endothelium and vascular smooth muscle. Bosentan decreases both pulmonary and systemic vascular resistance and is particularly used in the treatment of pulmonary arterial hypertension.
C47418	Bretylium_Tosylate	Antiarrhythmic_Agent	Bretylium Tosylate|(o-Bromobenzyl)ethyldimethylammonium p-Toluenesulfonate|2-Bromo-N-ethyl-N,N-dimethylbenzenemethanaminium 4-Methylbenzenesulfonate|BRETYLIUM TOSYLATE|Bretylol|Darentin	A quaternary ammonium salt and non-selective adrenergic neuronal blocking agent with anti-arrhythmic properties. Bretylium tosylate is selectively taken up into peripheral nerve terminals and initially causes a release of norepinephrine from sympathetic nerve endings, thereby causing a sympathomimetic effect. This is followed by a prolonged anti-adrenergic action which prevents further discharge of neurotransmitter from sympathetic nerve endings. Its myocardial effects include a prolongation of action potential as well as refractory period. This drug is used to treat and suppress ventricular arrhythmias, particularly ventricular fibrillation and ventricular tachycardia.
C47419	Brimonidine_Tartrate	Alpha-adrenergic_Agonist	Brimonidine Tartrate|6-Quinoxalinamine, 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-,(2R,3R)-2,3-dihydroxybutanedioate(1:1)|Alphagan|BRIMONIDINE TARTRATE|Lumigan	An imidazole derivative and a selective alpha-2 adrenergic receptor agonist. Upon ocular administration, brimonidine tartrate acts on the blood vessels causing them to constrict which leads to a decrease in the production of aqueous humor. Brimonidine tartrate also enhances the outflow of aqueous humor. This drug is used in the treatment of glaucoma to reduce intraocular pressure.
C47420	Brinzolamide	Anti-glaucoma_Agent	Brinzolamide|(R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno(3,2-e)-1,2-thiazine-6-sulfonamide|AL 4862|Azopt|BRINZOLAMIDE	A sulfonamide and carbonic anhydrase inhibitor with specific affinity for carbonic anhydrase II. Following topical ocular administration, brinzolamide inhibits carbonic anhydrase II, an enzyme that is responsible for the movement of sodium and fluid transport in the eye. This inhibition leads to a decrease in aqueous humor secretion, probably by slowing the formation of bicarbonate ions, and results in a reduction in intraocular pressure. Brindazolamide is used to treat increased pressure in the eye caused by open-angle glaucoma.
C47421	Bromodiphenhydramine_Hydrochloride	Histamine-1_Receptor_Antagonist	Bromodiphenhydramine Hydrochloride|2-((p-Bromo-alpha-phenylbenzyl)oxy)-N,N-dimethylethylamine Hydrochloride|2-(4-Bromobenzohydryloxy)-ethyl-dimethylamine Hydrochloride|Ambodryl Hydrochloride|BROMODIPHENHYDRAMINE HYDROCHLORIDE|Bromanyl|Ethanamine, 2-((4-bromophenyl)phenylmethoxy)-N,N-dimethyl-, Hydrochoride	A synthetic ethanolamine with histamine H1 antagonistic and sedative properties. Bromodiphenhydramine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. This drug also prevents histamine-induced pain and itching of mucous membranes.
C47422	Brompheniramine_Maleate	Histamine-1_Receptor_Antagonist	Brompheniramine Maleate|2-(p-Bromo-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine Maleate|2-Pyridinepropanamine, gamma-(4-Bromophenyl)-N,N-dimethyl-,(Z)-butenedioate(1:1)|BROMPHENIRAMINE MALEATE|Parabromdylamine Maleate
C47423	Bromthymol_Blue	Diagnostic_Reagent	Bromthymol Blue|4,4'-(3H-2,1-Benzoxathiol-3-ylidene)bis(2-bromo-3-methyl-6-(1-met-hylethyl)phenol) S,S-dioxide|BROMTHYMOL BLUE|Dibromothymolsulfophthalein
C47424	Buprenorphine_Hydrochloride	Opioid	Buprenorphine Hydrochloride|5alpha,7alpha(S))-alpha-tert-Butyl-17-(cyclopropylmethyl)-4,5-epoxy-18,19-dihydro-3-hydroxy-6-methoxy-alpha-methyl-6,14-ethenomorphinan-7-methanol Hydrochloride|BUPRENORPHINE HYDROCHLORIDE|Buprenex|NIH 8805|RX 6029-M HCl|Subutex	A synthetic phenanthrene with narcotic analgesic activity. Buprenorphine hydrochloride is a partial agonist at the mu-opioid receptor and an antagonist at the kapa-opioid receptor in the central nervous system. However, under the conditions of recommended use it behaves as a classic mu-opioid agonist, mimicking the actions of endogenous peptides at CNS opioid receptors. The agonist action results in a raised pain threshold and increased tolerance to pain.  However, it also causes sedation, physical dependence, and respiratory depressant effects and decreases heart rate and blood pressure.
C47425	Butalbital	Sedative_and_Hypnotic	Butalbital|2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(2-Methylpropyl)-5-(2-propenyl)-|5-Allyl-5-isobutylbarbituric Acid|Allylbarbital|Allylbarbituric Acid|BUTALBITAL|Optalidon	A barbiturate that exerts its effect by mimicking the inhibitory effect of gamma-aminobutyric acid (GABA) by binding to a site, distinct from the benzodiazepine binding site, on the GABA receptor. This leads to an increase in the duration of GABA-mediated opening of chloride channels and enhances the inhibitory effect of GABA. Consequently, its physiologic effects include sedation, hypnosis, reduction of anxiety, and respiratory depression and the drug causes tolerance and dependence.
C47426	Butenafine_Hydrochloride	Antifungal_Agent	Butenafine Hydrochloride|BUTENAFINE HYDROCHLORIDE|KP-363|Mentax|N-((4-(1,1-Dimethylethyl)phenyl)methyl)-N-methyl-1-naphthalenemethanamine Hydrochloride|N-4-tert-Butylbenzyl-N-methyl-1-naphthalenemethylamine Hydrochloride	A synthetic benzylamine derivative with fungicidal properties. Butenafine hydrochloride interferes with the biosynthesis of ergosterol, an important component of fungal cell membranes, by inhibiting the epoxidation of squalene. This alters fungal membrane permeability and causes growth inhibition. Butenafine hydrochloride is active against a number of dermatophytes, including Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis, Sporothrix schenckii, and yeasts, including Candida albicans and C. parapsilosis.
C47427	Butoconazole_Nitrate	Antifungal_Agent	Butoconazole Nitrate|(+-)-1-(4-(4-Chlorophenyl)-2-((2,6-dichlorophenyl)thio)butyl)-1H-imidazole Mononitrate|BUTOCONAZOLE NITRATE|Exelgyn|Femstat|Gynomyk|Mycelex-3|RS-35887	A synthetic imidazole derivative with fungistatic properties. Butoconazole nitrate interferes with steroid biosynthesis by inhibiting the conversion of lanosterol to ergosterol, thereby changing the fungal cell membrane lipid composition. This alters cell permeability and leads to growth inhibition. Butaconazole nitrate is active against many dermatophytes and yeasts. It also contains antibacterial effects against some gram-positive organisms.
C47428	Cabergoline	Antiparkinsonian_Agent	Cabergoline|1-((6-Allylergolin-8beta-yl)carbonyl)-1-(3-(dimethylamino)propyl)-3-ethylurea|CABERGOLINE|Dostinex|FCE 21336	A synthetic ergoline derivative and a long-acting dopamine receptor agonist with high affinity for the dopamine D2 receptor. Cabergoline exerts an inhibitory effect on prolactin secretion by acting on dopamine receptors present in pituitary lactotrophes. This drug also binds to dopamine D2 receptors in the corpus striatum, thereby mimicking the actions of dopamine on motor control. Cabergoline also possesses antioxidant and neuroprotective properties due to its free radical scavenging activity. Cabergoline is used in the treatment of Parkinson's disease and in the treatment of hyperprolactinemia.
C47429	Calcium_Acetate	Nutritional_Supplement	Calcium Acetate|Acetic Acid, Calcium Salt|CALCIUM ACETATE|Calphron|PhosLo	A calcium salt of acetic acid. Calcium is a mineral essential for many cellular functions including nerve impulse transmission, muscle contraction, cardiac function, bone formation, and capillary and cell membrane permeability. Calcium acetate is admixture orally to prevent or treat calcium deficiency and to treat hyperphosphatemia due to its phosphate-binding properties.
C47430	Carbachol	Anti-glaucoma_Agent	Carbachol|2-((Aminocarbonyl)oxy)-N,N,N-trimethylethanaminium Chloride|CARBACHOL|Carbastat|Carboptic|Isopto Carbachol|Miostat	A synthetic choline ester and a positively charged quaternary ammonium compound. Carbachol is a parasympathomimetic that mimics the effect of acetylcholine on both the muscarinic and nicotinic receptors. This drug is administered ocularly to induce miosis to reduce intraocular pressure in the treatment of glaucoma. Carbachol is also used to stimulate micturition by contraction of detrusor muscle. This drug may cause hypotension, bradycardia, nausea, vomiting, bronchospasm, and abdominal cramps.
C47431	Carbidopa	Antiparkinsonian_Agent	Carbidopa|(-)-L-alpha-Hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic Acid|Benzenepropanoic Acid, alpha-hydrazino-3,4-dihydroxy-alpha-methyl-,(S)-|CARBIDOPA|Lodosyn|alpha-Methyldopahydrazine	A hydrazine derivative of dopa. Carbidopa is a peripheral dopa decarboxylase inhibitor that is used as an adjunct to levodopa administration to prevent peripheral biosynthesis of levodopa to dopamine, thereby reducing peripheral side effects. Carbidopa does not penetrate the blood brain barrier so that levodopa, after it reaches the brain, can be metabolized to dopamine by dopa decarboxylase where it exerts its effect on dopamine receptors.
C47432	Carbinoxamine_Maleate	Histamine-1_Receptor_Antagonist	Carbinoxamine Maleate|2-(p-Chloro-alpha-(2-(dimethylamino)ethoxy)benzyl)pyridine Bimaleate|CARBINOXAMINE MALEATE|Ethanamine, 2-((4-chlorophenyl)-2-pyridinylmethoxy)-N,N-dimethyl-,(2Z)-2-butenedioate(1:1)|Palgic	An ethanolamine class of H1 antihistamines with mild antimuscarinic and sedative properties. Carbinoxamine diminishes the typical histaminergic effects on H1-receptors in bronchial smooth muscle, capillaries, and gastrointestinal smooth muscle, including vasodilation, bronchoconstriction, increased vascular permeability, pain, itching, and spasmodic contractions of gastrointestinal smooth muscle. Carbinoxamine maleate is used to provide symptomatic relieve of allergic symptoms.
C47433	Carboprost_Tromethamine	Miscellaneous_Adjuvant	Carboprost Tromethamine|(15S)-15-Methylprostaglandin F(sub 2alpha) Tromethamine|(15S)-9a, 11a, 15-Trihydroxy-15-methyl-prosta-cis-5, trans-13-dienoic Acid Tromethamine Salt|CARBOPROST TROMETHAMINE|Hemabate|Prosta-5,13-dien-1-oic acid, 9,11,15-trihydroxy-15-methyl-,(5Z,9-alpha,11-alpha,13E,15S)-, compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol(1:1)	A synthetic 15-methyl analogue of the naturally occurring prostaglandin F2alpha. Carboprost tromethamine induces myometrium smooth muscle contraction by binding to the prostaglandin F2alpha receptors. This drug can be used to induce contractions to end pregnancy or to induce labour and to control severe postpartum bleeding. Due to its contractile effects on gastrointestinal smooth muscle, carboprost tromethamine can cause vomiting and diarrhea.
C47434	Cefditoren_Pivoxil	Cephalosporin_Antibiotic	Cefditoren Pivoxil|5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-3-((1Z)-2-(4-methyl-5-thiazolyl)ethenyl)-8-oxo-,2,2-dimethyl-1-oxopropoxy)methyl Ester,(6R,7R)-|CCRIS 7768|CEFDITOREN PIVOXIL|ME 1207|Spectracef	A semi-synthetic, broad-spectrum, beta-lactam, third-generation cephalosporin antibiotic derived from cephalosporium. Cefditoren pivoxil is a prodrug that is rapidly hydrolyzed by intestinal esterases during absorption to the microbiologically active cefditoren. The bactericidal activity of cefditoren results from the inhibition of bacterial cell wall synthesis through interference with peptidoglycan synthesis. This results in a reduction of cell wall stability and causes cell lysis. Cefditoren pivoxil is more active against gram-negative and less active against gram-positive pathogens compared to second-generation cephalosporins. Cefditoren pivoxil is stable in the presence of a variety of beta-lactamases.
C47435	Cefoperazone_Sodium	Cephalosporin_Antibiotic	Cefoperazone Sodium|CEFOPERAZONE SODIUM|CP 52640-2|Cefobid|Sodium (6R,7R)-7-((R)-2-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-2-(p-hydroxyphenyl)acetamido)-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylate|T 1551	A semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic derived from cephalosporium. The bactericidal activity of cefoperazone sodium results from the inhibition of bacterial cell wall synthesis through inhibition of cross-linking of peptidoglycans. This results in a reduction of cell wall stability and causes cell lysis. Cefoperazone sodium is more effective against gram-negative bacteria but less effective against gram-positive bacteria than second-generation cephalosporins.
C47436	Ceforanide	Cephalosporin_Antibiotic	Ceforanide|(6R-trans)-7-(((2-(Aminomethyl)phenyl)acetyl)amino)-3-(((1-(carboxymethyl)-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid|CEFORANIDE|Precef	A semi-synthetic, broad-spectrum, beta-lactam, second-generation cephalosporin antibiotic derived from cephalosporium. Ceforanide is bactericidal due to the inhibition of bacterial cell wall synthesis through interference with peptidoglycan cross-linking. This results in a reduction of cell wall stability and causes cell lysis. Ceforanide is more active against gram-negative organisms and less active against gram-positive organisms compared to first-generation cephalosporins and is stable in the presence of a variety of beta-lactamases.
C47437	Cefotetan_Disodium	Cephalosporin_Antibiotic	Cefotetan Disodium|5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((4-(2-amino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl)carbonyl)amino)-7-methoxy-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-, Disodium Salt,(6R-(6alpha,7alpha))-|CEFOTETAN DISODIUM|Cefotan|Ceftenon|Cepan|Darvilen	A semi-synthetic, broad-spectrum, beta-lactamase-resistant, second-generation cephalosporin antibiotic derived from cephalosporium. The bactericidal activity of cefotetan disodium is caused by an inhibition of bacterial cell wall synthesis via inhibition of cross-linking of peptidoglycans. This results in a reduction of cell wall stability and causes cell lysis. Cefotetan disodium is more active against gram-negative organisms and less active against gram-positive organisms compared to first-generation cephalosporins.
C47438	Ceftizoxime_Sodium	Cephalosporin_Antibiotic	Ceftizoxime Sodium|5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 7-(((2,3-dihydro-2-imino-4-thiazolyl)(methoxyimino)acetyl)amino)-8-oxomonosodium Salt,(6R-(6alpha,7beta(Z)))-|CEFTIZOXIME SODIUM|Cefizox|Epocelin	A semi-synthetic, broad-spectrum, beta-lactamase resistant, third-generation cephalosporin antibiotic derived from cephasporium. The bactericidal activity of ceftizoxime sodium results from the inhibition of bacterial cell wall synthesis by inhibiting cross-linking of peptidoglycans. This results in a reduction of cell wall stability and causes cell lysis. Ceftizoxime sodium is more active against gram-negative and less active against gram-positive pathogens compared to second-generation cephalosporins.
C47439	Cefuroxime_Sodium	Cephalosporin_Antibiotic	Cefuroxime Sodium|5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, 3-(((aminocarbonyl)oxy)methyl)-7-((2-furanyl(methoxyimino)acetyl)amino)-8-oxo-, Monosodium Salt(6R-(6alpha,7beta(Z)))-|CEFUROXIME SODIUM|Cefurox|Kefurox|Lifurox|Zinacef	A semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic derived from cephasporium. The bactericidal activity of cefuroxime sodium results from the inhibition of bacterial cell wall synthesis through interference with the cross-linking of peptidoglycan units. This results in a reduction of cell wall stability and causes cell lysis. Cefuroxime sodium is more active against a variety of gram-negative organisms but less active against gram-positive pathogens compared to first-generation agents.
C47440	Cephapirin_Sodium	Cephalosporin_Antibiotic	Cephapirin Sodium|7-(D-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)-oct-2-ene-2-caboxylic Acid|7-(alpha-(4-Pyridylthio)acetamido)cephalosporanic acid sodium salt|Bristocef|CEPHAPIRIN SODIUM|Cefadyl|Cefalak|Cephatrexil	A semi-synthetic, broad-spectrum, beta-lactam, first-generation cephalosporin antibiotic derived from cephasporium. The bactericidal activity of cephapirin sodium results from the inhibition of bacterial cell wall synthesis via inhibition of cross-linking of peptidoglycan units. This results in a reduction of cell wall stability and causes cell lysis. Cephapirin sodium is active against a variety of gram-positive organisms but is less active against gram-negative bacteria.
C47441	Cephradine	Cephalosporin_Antibiotic	Cephradine|(6R,7R)-7-((R)-2-Amino-2-(1,4-cyclohexadien-1-yl)acetamido)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid|Velosef
C47442	Cetyl_Alcohol	Surfactant_Excipient	Cetyl Alcohol|1-Hexadecanol|CETYL ALCOHOL|Palmityl Alcohol|n-Hexadecyl Alcohol	A synthetic, solid, fatty alcohol and nonionic surfactant. Cetyl alcohol is used as an emulsifying agent in pharmaceutical preparations.
C47443	Chlordiazepoxide	Benzodiazepine	Chlordiazepoxide|3H-1,4-Benzodiazepin-2-amine, 7-chloro-N-methyl-5-phenyl, 4-oxide|CHLORDIAZEPOXIDE
C47444	Chloroprocaine_Hydrochloride	Anesthetic_Agent	Chloroprocaine Hydrochloride|2-Diethylaminoethyl 4-amino-2-chlorobenzoate Hydrochloride|Benzoic Acid, 4-amino-2-chloro-, 2-(diethylamino)ethyl Ester, Hydrochloride|CHLOROPROCAINE HYDROCHLORIDE|Nesacaine	A synthetic, aminoester, local, anesthetic agent. At the injection site, chloroprocaine hydrochloride acts by inhibiting sodium influx through binding to specific membrane sodium ion channels in the neuronal cell membranes, restricting sodium permeability, and blocking nerve impulse conduction. This leads to a loss of sensation. Chloroprocaine hydrochloride is short-acting due to rapid hydrolysis by pseudocholinesterase into para-aminobenzoic acid in plasma.
C47445	Chloroquine_Phosphate	Antimalarial_Agent	Chloroquine Phosphate|1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-, Phosphate (1:2)|7-Chloro-4-((4-(diethylamino)-1-methylbutyl)amino)quinoline Phosphate (1:2)|Aralen Phosphate|Avloclor|CHLOROQUINE PHOSPHATE|Tanakan	A quinoline compound with antimalarial and amebicide properties. Although the mechanism of action of chloroquine phosphate is uncertain, it is thought to inhibit the parasitic heme polymerase, an enzyme that converts the toxic heme into non-toxic hemazoin. This leads to an accumulation of toxic heme within the parasites. Another theory is that chloroquine phosphate binds and alters the properties of microbial DNA. Chloroquine phosphate is active against the erythrocytic forms of Plasmodium vivax and falciparum, and against gametocytes of P. vivax, P. malariae, and P. ovale.
C47446	Chloroxine	Anti-psoriatic_Agent	Chloroxine|5,7-Dichloro-8-hydroxyquinoline|CHLOROXINE|Capitrol	A synthetic quinoline derivative with antibacterial activity. Although the mechanism of action is not fully understood, topical administration of chloroxine diminishes mitotic activity in the epidermis, thereby reducing excessive scaling associated with dandruff or seborrheic dermatitis of the scalp, including psoriasis and eczema.
C47447	Chlorpropamide	Anti-diabetic_Agent	Chlorpropamide|Benzenesulfonamide, 4-chloro-N-((propylamino)carbonyl)-|CHLORPROPAMIDE|Diabinese|Urea, 1-((p-chlorophenyl)sulfonyl)-3-propyl-	A sulfonylurea with oral hypoglycemic properties that is used in the treatment of Type II diabetes mellitus. Chlorpropamide stimulates pancreatic secretion of insulin and improves insulin release by increasing sensitivity of beta cells to glucose stimuli. This drug also increases the sensitivity of insulin receptors in muscle, liver, and adipose tissue thereby promoting glucose transport across cell membranes. This results in better controlled blood glucose levels. Chlorpropamide has the longest duration of action of the sulfonylurea class but could cause more severe and frequent side effects, including hypoglycemia and hyponatremia.
C47448	Chlortetracycline_Hydrochloride	Tetracycline_Antibiotic	Chlortetracycline Hydrochloride|2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, Monohydrochloride(4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha))-|7-Chlorotetracycline Hydrochloride|CHLORTETRACYCLINE HYDROCHLORIDE	A tetracycline with broad-spectrum antibacterial and antiprotozoal activity. Chlortetracycline hydrochloride is bacteriostatic and inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, thereby preventing the addition of amino acids to the growing peptide chain. This tetracycline is active against a wide range of gram-positive and gram-negative organisms, spirochetes, rickettsial species, certain protozoa and Mycoplasma and Chlamydia organisms.
C47449	Chlorthalidone	Diuretic	Chlorthalidone|Benzenesulfonamide, 2-Chloro-5-(2,3-dihydro-1-hydroxy-3-oxo-1H-isoindol-1-yl)-|Benzenesulfonamide, 2-chloro-5-(1-hydroxy-3-oxo-1-isoindolinyl)-|CHLORTHALIDONE|Chlorphthalidolone|Hygroton|Thalitone	A thiazide diuretic of the sulfamoylbenzamide class. Chlorthalidone directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment in the distal convoluted tubule in the kidney. This leads to an increase in water, sodium, chloride, bicarbonate, and potassium secretion and a decrease in calcium and uric acid secretion. Chlorthalidone is used in the treatment of high blood pressure, edema and congestive heart failure.
C47450	Cinacalcet_Hydrochloride	Malignancy-Associated_Hypercalcemia_Inhibitor	Cinacalcet Hydrochloride|1-Naphthalenemethanamine, a-methyl-N-(3-(3-(trifluoromethyl)phenyl)propyl)-,(aR)-, Hydrochloride|CINACALCET HYDROCHLORIDE|Sensipar	An oral calcimimetic. Cinacalcet hydrochloride increases the sensitivity of the calcium-sensing receptors on the chief cells in the parathyroid gland to extracellular calcium, thereby reducing parathyroid hormone secretion. A reduction in parathyroid hormone levels inhibits osteoclast activity, favourably impacts bone-specific alkaline phosphatase, bone turnover, and bone fibrosis, and leads to normalization of serum calcium and phosphate levels. Cinacalcet hydrochloride is a treatment option for primary and secondary hyperparathyroidism and parathyroid carcinoma.
C47451	Cisatracurium_Besylate	Muscle_Relaxant	Cisatracurium Besylate|(1R,2R)-2-(2-Carboxyethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium Benzenesulfonate, Pentamethylene Ester|51W89|Atracurium besylate 1R-cis,1R'-cis form|CISATRACURIUM BESYLATE|Nimbex	A non-depolarizing skeletal muscle relaxant of the benzylisoquinolinium class. Cisatracurium besylate acts as a competitive acetylcholine antagonist that binds to nicotinic receptors at the neuromuscular junction. Compared to other neuromuscular blocking agents, it is intermediate in its onset and duration of action. Cisatracurium besylate is used to maintain neuromuscular relaxation during major surgical procedures, primarily to facilitate endotracheal intubation. Cisatracurium besylate can cause bronchospasms, hypotension, and bradycardia.
C47452	Citric_Acid	Antioxidant	Citric Acid|2-Hydroxy-1,2,3-propanetricarboxylic Acid|2-Hydroxypropanetricarboxylic Acid|CITRIC ACID	A tricarboxylic acid found in citrus fruits. Citric acid is used as an excipient in pharmaceutical preparations due to its antioxidant properties.  It maintains stability of active ingredients and is used as a preservative. It is also used as an acidulant to control pH and acts as an anticoagulant by chelating calcium in blood.
C47453	Clavulanate_Potassium	Beta-Lactam_Antibiotic	Clavulanate Potassium|4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-(2-hydroxyethylidene)-7-oxo-, Monopotassium Salt,(2R-(2alpha,3Z,5alpha))-|Amonate|CLAVULANATE POTASSIUM	A semi-synthetic beta-lactamase inhibitor isolated from streptomyces. Clavunalate potassium contains a beta-lactam ring and binds strongly to beta-lactamase at or near its active site. This protects other beta-lactam antibiotics from beta-lactamase catalysis. This drug is used in conjunction with beta-lactamase susceptible penicillins to treat infections caused by beta-lactamase producing organisms.
C47454	Clemastine_Fumarate	Histamine-1_Receptor_Antagonist	Clemastine Fumarate|(+)-2-(2-((p-Chloro-alpha-methyl-alpha-phenylbenzyl)oxy)ethyl)-1-methyl Pyrrolidine Fumarate|CLEMASTINE FUMARATE|Tavist	A synthetic ethanolamine with anticholinergic, sedative, and histamine H1 antagonistic properties. Clemastine fumarate blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial and gastrointestinal smooth muscles, including vasodilation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscles. This drug also prevents histamine-induced pain and itching of mucous membranes.
C47455	Clocortolone_Pivalate	Therapeutic_Glucocorticoid	Clocortolone Pivalate|9-Chloro-6alpha-fluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 21-pivalate|CLOCORTOLONE PIVALATE|Cloderm	A glucocorticoid receptor agonist with metabolic, anti-inflammatory, and immunosuppressive activity. Clocortolone pivalate exerts its effect by interacting with specific intracellular receptors and subsequently binds to DNA to modify gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are accomplished.
C47456	Clofazimine	Miscellaneous_Antibiotic	Clofazimine|2-Phenazinamine, 3,5-dihydro-N,5-bis(4-chlorophenyl)-3-((1-methylethyl)imino)-|3-(p-Chloranilino)-10-(p-chlorophenyl)-2,10-dihydro-2-(isopropylimino)-phenazine|CLOFAZIMINE|Lamprene	A phenazine dye with anti-mycobacterial and anti-inflammatory activity. The exact mechanism through which clofazime exerts its effect is unknown.  However, it binds preferentially to mycobacterial DNA, thereby inhibiting DNA replication and cell growth. Clofazimine has a slow bactericidal effect on Mycobacterium leprae and is active against various other Mycobacteria.
C47457	Cloflucarban	Topical_Anti-Infective_Agent	Cloflucarban|4,4'-Dichloro-3-(trifluoromethyl)-carbanilide|CLOFLUCARBAN|Halocarban|Irgasan|N-(4-Chlorophenyl)-N'-(4-chloro-3-(trifluoromethyl)phenyl)urea	A synthetic, carbanilide compound with antiseptic activity. Cloflucarban is used as disinfectant and is found in antimicrobial soaps and deodorants.
C47458	Clomipramine_Hydrochloride	Antidepressant_Agent	Clomipramine Hydrochloride|3-Chloro-5-(3-(dimethylamino)propyl)-10,11-dihydro-5H-dibenz(b,f)azepine monohydrochloride|3-Chloroimipramine Hydrochloride|Anafranil|CLOMIPRAMINE HYDROCHLORIDE|Clomipramine	A tertiary amine salt derivative of dibenzazepine. Clomipramine hydrochloride is a tricyclic antidepressant that acts by reducing the re-uptake of norepinephrine and serotonin in the central nervous system, thereby enhancing the effects of these neurotransmitters. This drug also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which are responsible for the many side effects seen with this agent.
C47459	Clorazepate_Dipotassium	Benzodiazepine	Clorazepate Dipotassium|1H-1,4-Benzodiazepine-3-carboxylic acid, 7-chloro-2,3-dihydro-2-oxo-5-phenyl-, Monopotassium Salt, compound with Potassium Hydroxide|CLORAZEPATE DIPOTASSIUM|Gen-Xene|Potassium 7-chloro-2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepine-3-carboxylate KOH|Tranxene	A benzodiazepine with anxiolytic, sedative, hypnotic, and anticonvulsant properties. Clorazepate dipotassium exerts its effect by de-activating the nervous system through potentiation of the inhibitory effect of gamma-aminobutyric acid (GABA) on the GABA-A receptors by binding to a site that is distinct from the GABA binding site. Its inhibitory effect is caused by an increase in GABA-mediated chloride channel opening events, leading to hyperpolarization and synaptic inhibition.
C47460	Cloxacillin_Sodium	Penicillin_Antibiotic	Cloxacillin Sodium|3-o-Chlorophenyl-5-methyl-4-isoxazolylpenicillin Sodium|4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(3-(2-chlorophenyl)-5-methyl-4-isoxazolecarboxamido)-3,3-dimethyl-7-oxo-, Monosodium Salt,(2S,5R,6R)-|CLOXACILLIN SODIUM|Cloxapen|Orbenin|Tegopen	A semi-synthetic beta-lactam penicillin antibiotic with beta-lactamase resistant activity. Cloxacillin sodium is bactericidal and binds to specific penicillin-binding proteins on the bacterium and inhibits the transpeptidation enzyme, thereby preventing the cross-linking of peptidoglycans. This leads to an interruption of the bacterial cell wall and causes bacterial lysis. Cloxacillin sodium is active against beta-lactamase producing staphylococci.
C47461	Cobalt_Chloride_Co-57	Radioconjugate	Cobalt Chloride Co-57|COBALT CHLORIDE, CO-57|Cobalt-57 Chloride|Cobaltous Chloride Co 57	A radioactive salt of the metal cobalt. Cobalt chloride Co-57 is a radiopharmaceutical used in nuclear medicine as an imaging agent in the diagnosis of certain forms of cancer.
C47462	Colfosceril_Palmitate	Surfactant_Excipient	Colfosceril Palmitate|(R)-(4-Oxido-10-oxo-7-palmitoyl-3,5,9-trioxa-4-phosphapentacosyl)trimethylammonium 4-Oxide|1,2-Dipalmitoyl-sn-glycero-3-phosphocholine|COLFOSCERIL PALMITATE|Exosurf Neonatal	A lung surfactant agent that is used as a replacement for endogenous lung surfactant. Colfosceril palmitate is effective in reducing the surface tension of pulmonary fluids, thereby increasing lung compliance properties to prevent alveolar collapse and improve breathing. This drug is used in the treatment of neonatal respiratory distress.
C47463	Corticorelin_Ovine_Triflutate	Miscellaneous_Hormone_Agent	Corticorelin Ovine Triflutate|Acthrel|CORTICORELIN OVINE TRIFLUTATE	A synthetic trifluoroacetate salt of Corticorelin Ovine, an analogue of the naturally occurring human corticotropin-releasing hormone (hCRH) peptide. Corticorelin ovine triflutate is a potent stimulator of adrenocorticotropic hormone (ACTH), secreted from the anterior pituitary gland. In turn, ACTH stimulates cortisol production from the adrenal cortex and is regulated by a negative feedback mechanism. Corticorelin ovine triflutate is used as a diagnostic tool in differentiating pituitary and ectopic production of ACTH.
C47464	Cyclacillin	Penicillin_Antibiotic	Cyclacillin|4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(((1-aminocyclohexyl)carbonyl)amino)-3,3-dimethyl-7-oxo-,(2S-(2alpha,5alpha,6beta))-|Aminocyclohexylpenicillin|CYCLACILLIN|Cyclapen-W|Wy-4508	A semi-synthetic beta-lactam aminocyclohexylpenicillin antibiotic. Cyclacillin is bactericidal and binds to specific penicllin-binding proteins, thereby inhibiting transpeptidation during peptidoglycan synthesis. This leads to an interruption of the bacterial cell wall, causing instability of bacterial cell wall and results in cell lysis. Cyclacillin is beta-lactamase susceptible.
C47465	Cyclobenzaprine_Hydrochloride	Muscle_Relaxant	Cyclobenzaprine Hydrochloride|1-Propanamine, 3-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-N,N-dimethyl-, Hydrochloride|10,11delta-Amitriptyline Hydrochloride|3-(5H-Dibenzo(a,d)cyclohepten-5-ylidene)propyl(dimethyl)ammonium Chloride|CYCLOBENZAPRINE HYDROCHLORIDE|Cloben|Cycloflex|FR2100873|Flexeril|Flexiban|Novo-Cycloprine	A centrally acting muscle relaxant, chemically similar to amitriptyline hydrochloride with antidepressant activity. The exact mechanism of action of cyclobenzaprine hydrochloride has not been fully determined.  However, it primarily acts at the brain stem to reduce tonic somatic motor activity, influencing both gamma and alpha motor neurons. This leads to a reduction in muscle spasms.
C47466	Cycloserine	Antitubercular_Agent	Cycloserine|(+)-4-Amino-3-isoxazolidinone|3-Isoxazolidinone, 4-amino-, d-|CYCLOSERINE|Oxamycin|Seromycin|Tisomycin	An analogue of the amino acid D-alanine and a broad-spectrum antibiotic. Cycloserine may be bactericidal or bacteriostatic, depending on its concentration at the infection site and the susceptibility of the organism. This antibiotic interferes with bacterial cell wall synthesis by competitively inhibiting two enzymes, L-alanine racemase and D-alanine:D-alanine ligase, thereby impairing peptidoglycan formation necessary for bacterial cell wall synthesis. Cycloserine is active against Mycobacterium tuberculosis.
C47467	Cysteamine_Bitartrate	Miscellaneous_Adjuvant	Cysteamine Bitartrate|CYSTEAMINE BITARTRATE|Cystagon	An aminothiol salt used in the treatment of nephropathic cystinosis. Cysteamine bitartrate enters the cell and reacts with cystine producing cysteine and cysteine-cysteamine mixed disulfide compound, both of which, unlike cystine, can pass through the lysosomal membrane. This prevents the accumulation of cystine crystals in the lysosomes of patients with cystinosis, which can cause considerable damage and eventual destruction of the cells, particularly in the kidneys. (NCI05)
C47468	Dalfopristin	Antibiotic	Dalfopristin|3R,4R,5E,10E,12E,14S,26R,26aS)-26-((2-(Diethylamino)ethyl)sulfonyl)-8,9,14,15,24,25,26,26a-octahydro-14-hydroxy-3-isopropyl-4,12-dimethyl-3H-21,18-nitrilo-1H,22H-pyrrolo(2,1-c)(1,8,4,19)dioxadiazacyclotetracosine-1,7,16,22(4H,17H)-tetrone|DALFOPRISTIN|Virginiamycin M1, 26-((2-(diethylamino)ethyl)sulfonyl)-26,27-dihydro-,(26R,27S)-	A semi-synthetic derivative of streptogramin A produced by streptomycetes. Dalfopristin inhibits the early phase of protein synthesis in the bacterial ribosome by binding to the 70S subunit, and also alters the configuration of the ribosome to make it more susceptible for streptogramin B binding. Dalfopristin is used in combination with quinopristin, a streptogramin B derivative. This combination is active against most gram-positive organisms, including Enterococcus faecium, and is also active against some gram-negative organisms and mycoplasma.
C47469	Dapiprazole_Hydrochloride	Alpha-adrenergic_Blocking_Agent	Dapiprazole Hydrochloride|1,2,4-Triazolo(4,3-a)pyridine, 5,6,7,8-tetrahydro-3-(2-(4-(2-methylphenyl)-1-piperazinyl)ethyl)-, monohydrochloride|AF 2139|DAPIPRAZOLE HYDROCHLORIDE|Rev-Eyes	An alpha1-adrenergic antagonist that acts by blocking alpha-adrenergic receptors in the smooth muscle of blood vessels (arteries, arterioles and veins), gastrointestinal tract, and radial smooth muscle of the iris. This prevents smooth muscle contraction and results in vasodilatation. Administered in the eye, dapiprazole hydrochloride produces miosis. In the heart, it may antagonize alpha-1 adrenoreceptors in myocytes causing a mild negative inotropic effect.
C47470	Daptomycin	Aminoglycoside_Antibiotic	Daptomycin|Cubicin|DAPTOMYCIN|LY146032|N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone	A semi-synthetic cyclic lipopeptide antibiotic derived from Streptomyces roseosporus. Daptomycin has a distinct mechanism of action, in which it binds to bacterial membrane and causes rapid depolarization of the cell membrane due to potassium efflux. The loss of membrane potential leads to inhibition of DNA, RNA and protein synthesis and eventually results in bacterial cell death. Daptomycin is unable to penetrate the outer membrane of gram-negative organisms. This antibiotic is used topically to treat infections caused by susceptible strains of gram-positive bacteria.
C47471	Daunorubicin_Citrate	Anthracycline_Antibiotic	Daunorubicin Citrate|DAUNORUBICIN CITRATE|DaunoXome	A semi-synthetic anthracycline glycoside antibiotic obtained from Streptomyces with antineoplastic activity. Daunorubicin citrate intercalates DNA, which leads to inhibition of DNA and RNA synthesis, and consequently blocks cell division and results in apoptosis. This anti-tumor antibiotic is most active in the S phase of cell division. Daunorubicin is indicated in the treatment of a wide variety of cancers including acute non-lymphocytic leukemia, non-Hodgkin's lymphomas, Ewing's sarcoma, Wilms' tumor, and chronic myelocytic leukemia. (NCI05)
C47472	Desflurane	Anesthetic_Agent	Desflurane|DESFLURANE|Ethane, 2-(difluoromethoxy)-1,1,1,2-tetrafluoro-,(+-)-|I 653|Suprane	A fluorinated ether and inhalation general anesthetic agent with analgesic and muscle relaxant activity. Although the exact mechanism through which desflurane exerts its effect has not been established, it probably acts on nerve cell membranes to disrupt neuronal transmission in the brain, probably via an action at the lipid matrix of the neuronal membrane. Desflurane may also enhance the activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) on synaptic transmission.
C47473	Desirudin	Anticoagulant_Agent	Desirudin|63-Desulfohirudin(Hirudo medicinalis isoform HV1)|CGP 39393|DESIRUDIN|Iprivask	A synthetic recombinant form of the naturally occurring hirudin, the anticoagulant substance found in leech. Desirudin is a selective and almost irreversible inhibitor of thrombin, both free and clot-bound, by blocking its active site. This anticoagulant agent has no effect on other components of the hemostatic system. Desirudin is particularly used to prevent deep vein thrombosis in patients undergoing hip and knee replacement surgery.
C47474	Desloratadine	Histamine-1_Receptor_Antagonist	Desloratadine|5H-Benzo(5,6)cyclohepta(1,2-b)pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene)-|Clarinex|DESLORATADINE|Sch 34117	A long-acting piperidine derivate with selective H1 antihistaminergic and non-sedating properties. Desloratadine diminishes the typical histaminergic effects on H1-receptors in bronchial smooth muscle, capillaries and gastrointestinal smooth muscle, including vasodilation, bronchoconstriction, increased vascular permeability, pain, itching and spasmodic contractions of gastrointestinal smooth muscle. Desloratidine is used to provide symptomatic relieve of allergic symptoms.
C47475	Desmopressin_Acetate	Therapeutic_Vasopressin	Desmopressin Acetate|1-(3-Mercaptopropionic acid)-8-D-arginine Vasopression Monoacetate|Concentraid|DDAVP|DESMOPRESSIN ACETATE|Octostim|Stimate	An analogue of the hormone vasopressin with antidiuretic and antihemorrhagic properties. Desmopressin acetate has selective affinity for the V2 receptor and acts on the distal kidney tubule by increasing the cellular permeability thereby stimulating water reabsorption. This antidiuretic agent is used in the treatment of central diabetes insipidus. An unrelated action of desmopressin acetate is to increases circulating factor VIII and is used in patients with haemophilia and von Willebrand's disease.
C47476	Desogestrel	Therapeutic_Progestin	Desogestrel|13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol|Cerazette|DESOGESTREL	A synthetic progestogen with progesterone hormone receptor agonistic activity. Desogestrel binds intracellular progesterone receptors in progesterone responsive tissue and the resultant complex interacts with DNA and results in either gene transcription or gene repression. This leads to an inhibition of LH release and prevents ovulation and alters the cervical mucus. Desogestrel is used in birth control pills alone or in combination with estrogens.
C47477	Desoximetasone	Therapeutic_Glucocorticoid	Desoximetasone|9-Fluoro-11-beta,21-dihydroxy-16-alpha-methylpregna-1,4-diene-3,20-dione|DESOXIMETASONE|Topicort|Topicort LP|Topsilon	A synthetic glucocorticoid receptor agonist with metabolic, anti-inflammatory and immunosuppressive activity. Desoximetasone activates specific intracellular receptors, which bind to distinct sites on DNA to modify gene transcription. This results in an induction of the synthesis of anti-inflammatory proteins and suppression of the synthesis of inflammatory mediators. This leads to an overall reduction in chronic inflammation and autoimmune reactions. Desoximetasone is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.
C47478	Dexchlorpheniramine_Maleate	Histamine-1_Receptor_Antagonist	Dexchlorpheniramine Maleate|(+)-2-(p-Chloro-alpha-(2-(dimethylamino)ethyl)benzyl)pyridine Maleate(1:1)|(gamma-(4-Chlorophenyl)-pyridine-2-propyl)(dimethyl)ammonium hydrogen(Z)-maleate|DEXCHLORPHENIRAMINE MALEATE|Mylaramine|Polaramine
C47479	Dexmedetomidine	Anesthetic_Agent	Dexmedetomidine|(+)-4-((S)-alpha,2,3-Trimethylbenzyl)imidazole|DEXMEDETOMIDINE|Precedex
C47480	Dexmethylphenidate_Hydrochloride	CNS_Stimulant	Dexmethylphenidate Hydrochloride|2-Piperidineacetic Acid, Alpha-phenyl-, Methyl Ester, Hydrochloride, (alphaR,2R)-|DEXMETHYLPHENIDATE HYDROCHLORIDE|Focalin|d-threo-Methylphenidate Hydrochloride	A synthetic sympathomimetic amine with CNS stimulating properties. Dexmethylphenidate hydrochloride acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from nerve terminals in the brain and inhibits their uptake. This leads to an increase in motor activity, causes euphoria, mental alertness and excitement and suppresses appetite. This drug causes dependence and may cause an increase in heart rate and blood pressure. It is used in the treatment of attention deficit hyperactivity disorder. It may also be used in the treatment of fatigue and other nervous system effects seen with chemotherapy.
C47481	Dexpanthenol	Miscellaneous_Adjuvant	Dexpanthenol|D-(+)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide|D-Pantothenyl Alcohol|DEXPANTHENOL|Ilopan|Motilyn|Pantenyl|Provitamin B5|d-Pantothenol	An alcoholic analogue of D-pantothenic acid and cholinergic agent. Dexpanthenol acts as a precursor of coenzyme A necessary for acetylation reactions and is involved in the synthesis of acetylcholine. Although the exact mechanism of the actions of dexpanthenol is unclear, it may enhance the effect of acetylcholine. Dexpanthenol acts on the gastrointestinal tract and increases lower intestinal motility. It is also applied topically to the skin to relieve itching and to promote healing.
C47482	Dextroamphetamine_Sulfate	CNS_Stimulant	Dextroamphetamine Sulfate|(S)-alpha-Methylbenzeneethanamine Sulfate|DEXTROAMPHETAMINE SULFATE|Dexedrine|d-alpha-Methylphenethylamine Sulfate	The salt of the dextro-isomer of amphetamine and sympathomimetic amine with CNS stimulating properties. Dextroamphetamine sulphate acts by facilitating the release of catecholamines, particularly noradrenaline and dopamine, from nerve terminals in the brain and inhibits their uptake. This leads to an increase in motor activity, causes euphoria, mental alertness and excitement and suppresses appetite. This drug causes dependence and may cause an increase in heart rate and blood pressure. It is used in the treatment of narcolepsy and attention deficit hyperactivity disorder.
C47483	Diatrizoate	Contrast_Agent	Diatrizoate|3,5-Bis(acetylamino)-2,4,6-triiodobenzoic Acid|Diatrizoic Acid|Urografin Acid|Urotrast
C47484	Dibenzothiophene	Miscellaneous_Adjuvant	Dibenzothiophene|2,2'-Biphenylylene Sulfide|DIBENZOTHIOPHENE|Dibenzo(b,d)thiophene|Diphenylene Sulfide
C47485	Dichlorophen	Antihelminthic_Agent	Dichlorophen|4,4'-Dichloro-2,2'-methylenediphenol|Anthiphen|Cordocel|DICHLOROPHEN|Parabis|Prevental|Teniathane|bis(2-Hydroxy-5-chlorophenyl)methane|bis(5-Chloro-2-hydroxyphenyl)methane
C47486	Diethylpropion_Hydrochloride	Anorexiant	Diethylpropion Hydrochloride|1-phenyl-2-diethyl-amino-1-propanone Hydrochloride|DIETHYLPROPION HYDROCHLORIDE|Tenuate|Tepanil	A sympathomimetic amine structurally similar to amphetamine with anorexiant activity. Diethylpropion hydrochloride stimulates the central nervous system and increases the release of norepinephrine and dopamine from nerve terminals and inhibits their uptake. This suppresses appetite, increases motor activity, causes euphoria, mental alertness and excitement. This drug may also cause an increase in heart rate and blood pressure. Diethylpropion hydrochloride is used in the treatment of obesity.
C47487	Difenoxin_Hydrochloride	Antidiarrheal_Agent	Difenoxin Hydrochloride|4-Piperidinecarboxylic Acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, Monohydrochloride|DIFENOXIN HYDROCHLORIDE|Isonipecotic Acid, 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-, Hydrochloride	A phenylpiperidine with antidiarrheal activity and active metabolite of diphenoxylate. Difenoxin is chemically related to the narcotic opioid meperidine. Difenoxin hydrochloride acts primarily on the gastrointestinal wall by binding to opioid receptors on acetylcholine-containing nerves and inhibits the release of acetylcholine from presynaptic nerve terminals. This leads to a reduction in intestinal motility. Difenoxin hydrochloride also mimics the action of endogenous opioid peptides at the CNS opioid receptors, (primarily mu-receptors), thereby inducing CNS effects.
C47488	Diflorasone_Diacetate	Therapeutic_Glucocorticoid	Diflorasone Diacetate|6alpha,9-Difluoro-11beta,17,21-trihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17,21-Diacetate|6alpha-Fluorobetamethasone-17,21 Diacetate|DIFLORASONE DIACETATE|Florone	A difluorophenyl derivate of salicylic acid and nonsteroidal anti-inflammatory agent with analgesic and antipyretic properties. Diflunisal inhibits cyclooxygenase I and II, thereby inhibiting prostaglandin synthesis locally at the inflammation site as well as in the gastrointestinal tract. It also blocks the synthesis of thromboxane A2 thereby inhibiting platelet aggregation and thrombus formation.
C47489	Diflunisal	Nonsteroidal_Antiinflammatory_Drug	Diflunisal|(1,1'-Biphenyl)-3-carboxylic Acid, 2',4'-difluoro-4-hydroxy-|2',4'-Difluoro-4-hydroxy-(1,1'-biphenyl)-3-carboxylic Acid|Apo-Diflunisal|DIFLUNISAL|Dolobid|Flovacil|Novo-Diflunisal|Nu-Diflunisal
C47490	Dihydrocodeine_Bitartrate	Opioid	Dihydrocodeine Bitartrate|Codeine, dihydro-, Tartrate(1:1)|DIHYDROCODEINE BITARTRATE|Dihydrocodeine Acid Tartrate|Morphinan-6-alpha-ol, 4,5-alpha-epoxy-3-methoxy-17-methyl-, Tartrate(1:1)|Parzone|Tuscodin	A synthetic opioid analgesic. Dihydrocodeine bitartrate mimics the actions of the endogenous opioid peptides due to its agonistic effects on the opioid receptors. Stimulation of the mu receptors produces the typical narcotic effects of analgesia, miosis, euphoria, respiratory depression, sedation, physical dependence and bradycardia. Dihydrocodeine bitartrate is twice as potent as codeine and has one third of the potency of morphine. This analgesic is used for the relief of moderate to moderately severe pain.
C47491	Dihydroergotamine_Mesylate	Serotonin_Agonist	Dihydroergotamine Mesylate|9,10-Dihydroergotamine Mesylate|DIHYDROERGOTAMINE MESYLATE|Ergotoman-3',6',18-trione,9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-,(5'alpha)-, monomethanesulfonate(salt)|Migranal	An ergot derivative with agonistic activity for alpha-adrenergic, serotonergic, and dopaminergic receptors. Dihydroergotamine mesylate most likely relieves migraine headaches by binding to and stimulating the 5-HT1D receptor subtype, thereby causing constriction of cerebral blood vessels. However, it has also been proposed that dihydroergotamine mesylate acts upon 5-HT1D receptors on sensory nerve endings of the trigeminal system, thereby decreasing the release of pro-inflammatory neuropeptide release.
C47492	Dihydrostreptomycin_Sulfate	Aminoglycoside_Antibiotic	Dihydrostreptomycin Sulfate|D-Streptamine, O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-(hydroxymethyl)-alpha-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-, Sulfate(2:3)(salt)|DIHYDROSTREPTOMYCIN SULFATE|Dihydrostreptomycin Sequisulphate	A semi-synthetic aminoglycoside antibiotic with bactericidal properties. Dihydrostreptomycin sulfate inhibits protein synthesis by binding to the 30S ribosomal subunit. This antibiotic is active against most gram-positive and gram-negative organisms and is used in the treatment of tuberculosis and tulemia.
C47493	Diltiazem_Malate	Calcium_Channel_Blocker	Diltiazem Malate|1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(di-methylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-(2S-cis)-,(S)-hydoxybutanedioate(1:1)|DILTIAZEM MALATE	A benzothiazepine derivative and calcium channel blocker with vasodilator, antihypertensive and cardiovascular activity. Diltiazem maleate inhibits the influx of calcium ions of coronary and peripheral vascular smooth muscle. This leads to a dilation of peripheral and coronary blood vessels, and results in a reduction of myocardial oxygen requirement and in an increase in myocardial oxygen delivery. In addition, diltiazem maleate has a potent negative chronotropic effect with only a mild negative inotropic effect. This drug is used as an antiarrhythmic and an antianginal agent.
C47494	Dimercaprol	Chelating_Agent	Dimercaprol|1,2-Dithioglycerol|2,3-Dimercapto-1-propanol|BAL in Oil|DIMERCAPROL	A metal chelating agent that is used as an antidote in arsenic, gold, lead, mercury and other heavy metal poisoning. Metals form ligands in the body with the sulfhydryl groups of the pyruvate-oxidase enzyme system. This leads to an inhibition of the normal functioning of these enzymes that are dependent on free sulfhydryl groups for their activity. Dimercaprol reverses the enzyme inhibition by chelating the metal and regenerates free sulfhydryl groups, thereby preventing and reversing the metals toxic effects.
C47495	Dipivefrin_Hydrochloride	Anti-glaucoma_Agent	Dipivefrin Hydrochloride|(1)-4-(1-Hydroxy-2-(methylamino)ethyl)-1,2-phenylene Dipivalate Hydrochloride|Alcon|DIPIVEFRIN HYDROCHLORIDE|Propanoic Acid, 2,2-dimethyl-, 4-(1-hydroxy-2-(methylamino)ethyl)-1,2-phenylene Ester, Hydrochloride,(+-)-|Propine	An ester with symphatomimetic activities. Dipivefrin hydrochloride is a prodrug of epinephrine that, due to its greater lipophilicity, allows for better penetration into the anterior chamber. Once inside the eye, dipivefrin hydrochloride is converted by hydrolysis to epinephrine. Epinephrine enhances the outflow of aqueous humor and decreases the production of aqueous humor by vasoconstriction. This leads to a reduction in intraocular pressure.
C47496	Dirithromycin	Macrolide_Antibiotic	Dirithromycin|DIRITHROMYCIN|Dynabac|Erythromycin, 9-deoxo-11-deoxy-9,11-(imino(2-(2-methoxyethoxy)ethylidene)oxy)-,(9S(R))-	A semi-synthetic macrolide antibiotic pro-drug. Dirithromycin is converted by hydrolysis during intestinal absorption into the microbiologically active erythromycylamine. Eryhtromylamine binds to the 50 S subunit of the 70 S ribosome of susceptible organisms, thereby inhibiting bacterial RNA-dependent protein synthesis. This antibiotic is used in the treatment of infections of the respiratory tract, skin and soft tissue caused by gram-postive microorganisms, including S. aureus, S. pneumonia and pyogenes, gram-negative microorganisms, including H. influenzae, L. pneumophila, M. catarrhalis, and M. pneumoniae.
C47497	Disopyramide_Phosphate	Antiarrhythmic_Agent	Disopyramide Phosphate|2-(1-(Ammoniocarbonyl)-3-(diisopropylammonio)-1-phenylpropyl)pyridinium Phosphate|DISOPYRAMIDE PHOSPHATE|Norpace|Rythmodan|alpha-(2-(Diisopropylamino)ethyl)-alpha-phenyl-2-pyridineacetamide Phosphate(1:1)	A class Ia antiarrhythmic agent with cardiac depressant properties. Disopyramide phosphate exerts its actions by blocking both sodium and potassium channels in cardiac membrane during phase 0 of the action potential. This slows the impulse conduction through the AV node and prolongs the duration of the action potential of normal cardiac cells in atrial and ventricular tissues. Disopyramide prolongs the QT interval and causes a widening of the QRS complex. It also posesses some anticholinergic and local anaesthetic properties. Disopyramide phosphate is used in the treatment of supraventricular tachycardia.
C47498	Docosanol	Miscellaneous_Antiviral_Agent	Docosanol|Abreva|Behenyl Alcohol|DOCOSANOL	A saturated 22-carbon aliphatic alcohol with antiviral activity. Docosanol has a distinct mechanism of action and inhibits fusion between the plasma membrane and the herpes simplex virus envelope, thereby preventing viral entry into cells and subsequent viral activity and replication. Docosanol is used topically in the treatment of recurrent herpes simplex labialis episodes and relieves associated pain and may help heal sores faster.
C47499	Dofetilide	Antiarrhythmic_Agent	Dofetilide|DOFETILIDE|Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl-|Tikosyn|beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide	A sulfonamide class III antiarrhythmic agent and potassium channel blocker. Dofetilide selectively blocks cardiac ion channels of the rapid component of the delayed rectifier potassium current Ikr. This antiarrhythmic agent prolongs cardiac action potential duration and effective refractory period due to delayed repolarization without affecting conduction velocity. This results in a normal sinus rhythm. Dofetilide is used in the treatment of atrial fibrillation and flutter.
C47500	Doxapram_Hydrochloride	CNS_Stimulant	Doxapram Hydrochloride|1-ethyl-4-[2-(4-morpholinyl)ethyl]-3,3-diphenyl-2-pyrrolidinone Monohydrochloride, Monohydrate|3,3-Diphenyl-1-ethyl-4-(2-morpholinoethyl)-2-pyrrolidinone Hydrochloride|DOXAPRAM HYDROCHLORIDE|Dopram|Stimulexin	A peripheral and central respiratory stimulant with a brief duration of action. Doxapram hydrochloride stimulates respiration by an action on chemoreceptors in the carotid arteries and, at increased dosage, stimulates central respiratory centers in the medulla as well as other parts of the brain and spinal cord. This results in an increased tidal volume and a slightly increased respiratory rate. Doxapram hydrochloride may also improve cardiac output probably due to an increased release of catecholamines. This respiratory stimulant is used in postanesthesia respiratory depression.
C47501	Doxylamine_Succinate	Antihistamine	Doxylamine Succinate|Butanedioic Acid, compound with N,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy]ethanamine(1:1)|DOXYLAMINE SUCCINATE|Decapryn|Dimethylaminoethoxy-methyl-benzyl-pyridine Succinate|Mereprine|N,N-dimethyl-2-[1-phenyl-1-(2-pyridinyl)ethoxy] ethanamine, butanedioate(1:1)|Sedaplus|Unisom	A pyridine derivate histamine H1 antagonist with pronounced sedative properties. Doxylamine succinate competitively blocks the histamine H1 receptor and limits the typical allergic and anaphylactic responses, including bronchoconstriction, vasodilation, increased capillary permeability, and spasmodic contraction of gastrointestinal smooth muscle, caused by actions of histamine on bronchial and gastrointestinal smooth muscles, and on capillaries. This drug also prevents histamine-induced pain and itching of the skin and mucous membranes.
C47502	Drospirenone	Therapeutic_Progestin	Drospirenone|(6R,7R,8R,9S,10R,13S,14S,15S,16S,17S)-1,3',4',6,6a,7,8,9,10,11,12,13,14,15,15a,16-Hexadecahydro-10,13-dimethylspiro-(17H-dicyclopropa(6,7:15,16)cyclopenta(a)phenanthrene-17,2'(5'H)-furan)-3,5'(2H)-dione|1,2-Dihydrospirorenone|6-beta,7-beta;15-beta,16-beta-Dimethylene-3-oxo-17-alpha-pregn-4-ene-21,17-carbolactone|DROSPIRENONE	A synthetic spironolactone analogue and progestin with progestational and anti-mineralocorticoid activity. Drospirenone binds to the progesterone receptor, the resulting complex becomes activated and binds to specific sites on DNA. This results in a suppression of LH activity and an inhibition of ovulation as well as an alteration in the cervical mucus and endometrium. This leads to an increased difficulty of sperm entry into the uterus and implantation. This drug is used in oral contraceptives.
C47503	Dutasteride	Anti-Androgen	Dutasteride|Avodart|Avolve,(5alpha,17beta)-N-(2,5-Bis(trifluoromethyl)phenyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide|DUTASTERIDE|GG 745|alpha,alpha,alpha,alpha',alpha',alpha'-Hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide	A synthetic 4-azasteroid compound. Dutasteride competitively and specificly inhibits both 5-alpha-reductase 1 and 2 isoenzymes that convert testosterone to dihydrotestosterone. The type 2 isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also responsible for conversion of testosterone in the skin and liver. Inhibition of 5-alpha reductase leads to a reduction of dihydrotestosterone formation and subsequently prevents the enlargement of the prostate gland. Dutasteride is used in the treatment of benign prostatic hyperplasia.
C47504	Dyphylline	Bronchodilator	Dyphylline|1H-Purine-2,6-dione, 7-(2,3-dihydroxypropyl)-3,7-dihydro-1,3-dimethyl|7-(2,3-Dioxypropyl)theophylline|DYPHYLLINE|Dilor|Diprophylline|Dylix|Lyfillin|Neothylline	A xanthine derivative. Dyphilline exerts bronchodilator effects and to a lesser extent vasodilator and diuretic properties. Dyphilline probably acts as a competitive inhibitor of phosphodiesterase which leads to an increase in intracellular cAMP. This results in relaxation of bronchial smooth muscle and other smooth muscles. Dyphylline may also antagonize adenosine receptors. Dyphylline is used in the treatment of acute bronchial asthma, chronic bronchitis and emphysema.
C47505	Echothiophate_Iodide	Acetylcholinesterase_Inhibitor	Echothiophate Iodide|(2-Mercaptoethyl)trimethylammonium Iodide S-ester with O,O-diethyl Phosphorothioate, Diethoxyphosphoryl-thiocholine Iodide|2-((Diethoxyphosphinyl)thio)-N,N,N,-trimethylethanaminium Iodide|ECHOTHIOPHATE IODIDE|Phospholine Iodide	A long-acting cholinesterase inhibitor with parasympathomimetic properties. Intraocular, echothiophate iodide enhances the actions of acetylcholine thereby producing miosis and increasing aqueous humor outflow. This results in a reduction of intraocular pressure. Echothiophate iodide is used in the treatment of glaucoma.
C47506	Econazole_Nitrate	Antifungal_Agent	Econazole Nitrate|1-[2-{(4-chloro-phenyl)methoxy}-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole Mononitrate|ECONAZOLE NITRATE|Ifenec|Pevaryl|R 14827|Spectazole	An imidazole derivative and broad-spectrum antimycotic agent with fungistatic properties. Econazole nitrate inhibits biosynthesis of ergosterol, thereby damaging the fungal cell wall membrane and altering its permeability which leads to a loss of essential intracellular components. In addition, econazole nitrate inhibits biosynthesis of triglycerides and phospholipids and inhibits oxidative and peroxidative enzyme activity which may contribute to cellular necrosis and cell death. Econazole nitrate is also active against some gram positive bacteria. This antifungal agent is used in the treatment various dermatomycoses.
C47507	Edrophonium_Chloride	Acetylcholinesterase_Inhibitor	Edrophonium Chloride|Antirex|Benzenaminium, N-ethyl-3-hydroxy-N,N-dimethyl-, Chloride|EDROPHONIUM CHLORIDE|Enlon|Ethyl(m-hydroxyphenyl) Dimethylammonium Chloride|Reversol|Tensilon	A short and rapid-acting cholinergic agent. Edrophonium chloride inhibits cholinesterase, thereby enhancing the effects of acetylcholine on muscarinic and nicotinic receptors. This drug is mainly used for differential diagnosis and evaluation of treatment requirements in myasthenia gravis and as an antagonist to nondepolarizing neuromuscular blocking agents.
C47508	Eletriptan_Hydrobromide	Serotonin_Agonist	Eletriptan Hydrobromide|3-[[(R)-1-Methyl-2-pyrrolidinyl]methyl]-5-[2-(phenylsulfonyl)ethyl]indole, Monohydrobromide|ELETRIPTAN HYDROBROMIDE|Relpax	A triptan with specific affinity for the 5-hydroxytriptamine1B/1D receptor. Eletriptan hydrobromide binds to and acts at serotonin 5-HT1B receptors located on intracranial blood vessels which leads to vasoconstriction. This drug may also exerts its effects by binding to and activating 5-HT 1D receptors on sensory nerve endings in the trigeminal system, which results in the inhibition of pro-inflammatory neuropeptide release. Eletriptan hydrobromide is used to relieve pain in nerve endings and associated symptoms caused by migraine headaches.
C47509	Emtricitabine	Anti-HIV_Agent	Emtricitabine|(-)-2'-Deoxy-5-fluoro-3'-thiacytidine|2(1H)-Pyrimidinone, 4-amino-5-fluoro-1-(2-(hydroxymethyl)-1,3-oxathiolan-5-yl)-,(2R-cis)-|Coviracil|EMTRICITABINE|Emtriva|FTC	A synthetic nucleoside analog of cytosine with activity against human immunodeficiency virus type 1 reverse transcriptase. Emtricitabine is phosphorylated by cellular enzymes to form emtricitabine 5'-triphosphate. Emtricitabine 5'-triphosphate inhibits the activity of the HIV-1 reverse transcriptase by competing with the natural substrate deoxycytidine 5'-triphosphate. Incorporation of emtricabine 5'-triphosphate into nascent viral DNA results in chain termination. Emtricitabine 5'-triphosphate is a weak inhibitor of mammalian DNA polymerase alpha, beta, epsilon and mitochondrial DNA polymerase gamma.
C47510	Enalaprilat	ACE_Inhibitor|Antihypertensive_Agent	Enalaprilat|Accuprill|Capoten|ENALAPRILAT|N-(1(S)-Carboxy-3-phenylpropyl)-L-alanyl-L-proline|Vasotec	The intravenously adminstered active metabolite of the oral pro-drug enalapril and angiotensin-converting enzyme inhibitor. Enlaprilat inhibits angiotensin converting enzyme thereby prevention the conversion of angiotensin I into angiotensin II. This leads to decreased vasopressor activity and results in vasodilation. Enalapril also decreases aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow. Enalaprilat is effective in the treatment of hypertensive crisis.
C47511	Enflurane	Anesthetic_Agent	Enflurane|2-Chloro-1,1,2-trifluoroethyl difluoromethyl Ether|2-Chloro-1-(difluoromethoxy)-1,1,2-trifluoroethane|ENFLURANE|Ethrane|Methylflurether	A fluorinated ether and very potent and stable general anaesthetic agent. The mechanism through which enflurane exerts its effect is not clear, it probably acts on nerve cell membranes to disrupt neuronal transmission in the brain, probably via an action at the lipid matrix of the neuronal membrane. Enflurane may also enhance the activity of the inhibitory neurotransmitter gamma-aminobutyric acid on synaptic transmission. Enflurane may also inhibit glutamatergic excitatory transmission.
C47512	Epinastine_Hydrochloride	Histamine-1_Receptor_Antagonist	Epinastine Hydrochloride|9,13b-Dihydro-1H-dibenz(c,f)imidazo(1,5-a)azepin-3-amine Hydrochloride|Alesion|EPINASTINE HYDROCHLORIDE|Elestat	An histamine H1 receptor antagonist without sedative activity. Epinastine hydrochloride blocks the histamine H1 receptor and inhibits the release of histamine from mast cells. This prevents the typical allergic symptoms that are caused by histamine activity on capillaries, skin, mucous membranes, and on gastrointestinal and bronchial smooth muscles. Typical histamine activities include vasodilation, bronchoconstriction, increased vascular permeability, pain, itching, and spasmodic contractions of gastrointestinal smooth muscles. Epinastine also has affinity for the histamine H2, 5-HT2, and the alpha1, alpha2 adrenergic receptors.
C47513	Eplerenone	Antihypertensive_Agent	Eplerenone|9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid, gamma-lactone, Methyl Ester|EPLERENONE|Inspra	A selective aldosterone receptor antagonist. Eplerenone binds to the mineralocorticoid receptor and blocks the binding of aldosterone, thereby decreasing sodium resorption and subsequently increasing water outflow. This leads to a decrease in blood pressure. Eplerone is used in the treatment of hypertension and congestive heart failure.
C47514	Epoprostenol_Sodium	Antihypertensive_Agent	Epoprostenol Sodium|Cyclo-Prostin|EPOPROSTENOL SODIUM|Flolan|Prosta-5,13-dien-1-oic acid, 6,9-epoxy-11,15-dihydroxy-, Sodium salt, (5Z,9alpha,11alpha,13E,15S)-|Sodium(Z)-(3aR,4R,5R,6aS)-hexahydro-5-hydroxy-4-((E)-(3S)-3-hydroxy-1-octenyl)-2H-cyclopenta(b)furan-delta(sup 2,delta)-valerate
C47515	Eprosartan_Mesylate	Antihypertensive_Agent	Eprosartan Mesylate|(E)-2-Butyl-1-(p-carboxybenzyl)-alpha-2-thenylimidazole-5-acrylic Acid, Monomethanesulfonate|2-Thiophenepropanoic Acid, alpha-((2-butyl-1-((4-carboxyphenyl)methyl)-1H-imidazol-5-yl)methylene)-,(E)-, Monomethanesulfonate|EPROSARTAN MESYLATE|Teveten
C47516	Eptifibatide	Anticoagulant_Agent	Eptifibatide|EPTIFIBATIDE|Integrelin|L-Cysteinamide, N6-(aminoiminomethyl)-N2-(3-mercapto-1-oxopropyl)-L-lysylglycyl-L-alpha-aspartyl-L-tryptophy-L-prolyl-, cyclic(1-6)-disulfide
C47517	Ergotamine_Tartrate	Serotonin_Agonist	Ergotamine Tartrate|ERGOTAMINE TARTRATE|Ergostat|Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-,(5'alpha)-,(2R,3R)-2,3-dihydroxybutanedioate(2:1)(salt)|Femergin|Lingran|Secupan
C47518	Escitalopram_Oxalate	Antidepressant_Agent	Escitalopram Oxalate|5-Isobenzofurancarbonitrile, 1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydro-,(1S)-, ethanedioate(1:1)|ESCITALOPRAM OXALATE|Lexapro|Lu 26-054-0
C47519	Esmolol_Hydrochloride	Beta-Adrenergic_Blocking_Agent	Esmolol Hydrochloride|(+-)-Methyl p-(2-hydroxy-3-(isopropylamino)propoxy)hydrocinnamate Hydrochloride|4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoic Acid Methyl Ester HCl|ASL 8052|Brevibloc|ESMOLOL HYDROCHLORIDE
C47520	Estazolam	Benzodiazepine	Estazolam|8-Chloro-6-phenyl-4H-(1,2,4)triazolo-(4,3-a)(1,4)benzodiazepine|ESTAZOLAM|Esilgan|ProSom
C47521	Estropipate	Therapeutic_Estrone	Estropipate|ESTROPIPATE|Estrone Hydrogen Sulfate compound with Piperazine(1:1)|Ogen|Ortho-Est, Estra-1,3,5(10)-trien-17-one 3-sulphate, compound with Piperazine(1:1)|Piperazine, compound with 3-(Sulfooxy)estra-1,3,5(10)-trien-17-one(1:1)(9CI)|Sulestrex
C47522	Ethionamide	Antitubercular_Agent	Ethionamide|2-Ethyl-4-pyridinecarbothioamide|2-Ethylthioisonicotinamide|ETHIONAMIDE|Trecator-SC
C47523	Ethosuximide	Anticonvulsant_Agent	Ethosuximide|3-Ethyl-3-methylpyrrolidine-2,5-dione|ETHOSUXIMIDE|Zarontin
C47524	Ethotoin	Anticonvulsant_Agent	Ethotoin|3-ethyl-5-phenyl-2,4-imidazolidinedione|ETHOTOIN|Hydantoin, 3-ethyl-5-phenyl-|Peganone
C47525	Ethynodiol_Diacetate	Therapeutic_Progestin	Ethynodiol Diacetate|(3-beta,17-alpha)-19-Norpregn-4-en-20-yne-3,17-diol Diacetate|17-alpha-Ethynyl-19-norandrost-4-ene-3-beta,17-beta-diol Diacetate|ETHYNODIOL DIACETATE
C47526	Etodolac	Nonsteroidal_Antiinflammatory_Drug	Etodolac|1,3,4,9-Tetrahydro-1,8-diethylpyrano(3,4-b)indole-1-acetic Acid|ETODOLAC|Lodine|Ultradol
C47527	Etomidate	Anesthetic_Agent	Etomidate|1H-Imidazole-5-Carboxylic Acid, 1-((1R)-1-phenylethyl)-, Ethyl Ester|Amidate|ETOMIDATE|R-(+)-Ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate
C47528	Etonogestrel	Therapeutic_Progestin	Etonogestrel|(17-alpha)-13-Ethyl-17-hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one|3-Keto-Desogestrel|ETONOGESTREL|Implanon
C47529	Ezetimibe	Anti-lipidemic_Agent	Ezetimibe|1-(4-fluorophenyl)-3(R)-[3-(4-fluorophenyl)-3(S)-hydroxypropyl]-4(S)-(4-hydroxyphenyl)-2-azetidinone|EZETIMIBE|Ezedoc|Zetia
C47530	Felbamate	Anticonvulsant_Agent	Felbamate|2-Phenyl-1,3-propanediol Dicarbamate|Carbamic Acid, 2-phenyltrimethylene Ester|FELBAMATE|Felbatol
C47531	Fenoldopam_Mesylate	Vasodilating_Agent	Fenoldopam Mesylate|6-Chloro-2,3,4,5-tetrahydro-1-(p-hydroxyphenyl)-1H-3-benzazepine-7,8-diol methanesulfonate(salt)|Corlopam|FENOLDOPAM MESYLATE
C47532	Ferric_Hexacyanoferrate_II	Chelating_Agent	Ferric Hexacyanoferrate (II)|Antidotum Thallii-Heyl|FERRIC HEXACYANOFERRATE(II)|Ferrocin|Insoluble Prussian Blue|Iron Ferrocyanide|Radiogardase-Cs
C47533	Flavoxate_Hydrochloride	Muscle_Relaxant	Flavoxate Hydrochloride|2-piperidinoethyl 3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate Hydrochloride|4H-1-Benzopyran-8-carboxylic Acid, 3-methyl-4-oxo-2-phenyl-, 2-(1-piperidinyl)ethyl Ester, Hydrochloride|DW 61|FLAVOXATE HYDROCHLORIDE|Spasmal|Urispas
C47534	Flumazenil	Protective_Agent	Flumazenil|4H-Imidazo(1,5-a)(1,4)benzodiazepine-3-carboxylic Acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, Ethyl Ester|Anexate|FLUMAZENIL|Lanexat|Ro 151788|Romazicon
C47535	Fluorometholone_Acetate	Therapeutic_Glucocorticoid	Fluorometholone Acetate|9-Fluoro-11beta,17-dihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 17-acetate|Eflone|FLUOROMETHOLONE ACETATE|Flarex
C47536	Fluphenazine	Antipsychotic_Agent	Fluphenazine|1-Piperazineethanol, 4-(3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)propyl)-(9CI)
C47537	Flurandrenolide	Therapeutic_Glucocorticoid	Flurandrenolide|6alpha-Fluoro-11beta,16alpha,17,21-tetrahydroxypregn-4-ene-3,20-dione, cyclic 16,17-acetal with Acetone|Cordran|FLURANDRENOLIDE|Fludroxycortide
C47538	Fomepizole	Enzyme_Inhibitor	Fomepizole|1H-Pyrazole, 4-methyl-|4-Methylpyrazol|Antizol|FOMEPIZOLE	A pyrazole with competitive alcohol dehydrogenase inhibitor activity. Fomepizole prevents the metabolism of ethylene glycol and methanol by alcohol dehydrogenase, thereby inhibiting the formation of their toxic metabolites, glycolate and oxalate (from ethylene glycol), and formic acid (from methanol). Fomepizole is indicated for use as an antidote in ethylene glycol and methanol poisoning. (NCI05)
C47539	Fondaparinux_Sodium	Anticoagulant_Agent	Fondaparinux Sodium|Arixtra|FONDAPARINUX SODIUM|alpha-D-Glucopyranoside, methyl O-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranosyl-(1-4)-O-beta-D-glucopyranuronosyl(1-4)-O-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranosyl-(1-4)-O-2-O-sulfo-alpha-L-idopyranuronosyl-(1-4)-2-deoxy-2-(sulfoamino)-, 6-(hydrogen sulfate)|decasodium salt	The sodium salt form of fondaparinux, a synthetic glucopyranoside with antithrombotic activity. Fondaparinux sodium selectively binds to antithrombin III, thereby potentiating the innate neutralization of activated factor X (Factor Xa) by antithrombin. Neutralization of Factor Xa inhibits its activity and interrupts the blood coagulation cascade, thereby preventing thrombin formation and thrombus development. (NCI05)
C47540	Formoterol_Fumarate	Bronchodilator	Formoterol Fumarate|FORMOTEROL FUMARATE|Foradil|Formamide, N-(2-hydroxy-5-((1R)-1-hydroxy-2-(((1R)-2-(4-methoxyphenyl)-1-methylethyl)amino)ethyl)phenyl)-, rel-,(E)-2-butenedioate(2:1)(salt)	The fumarate salt form of formoterol, a long-acting and selective sympathomimetic beta-receptor agonist with bronchodilator activity. Formoterol fumarate binds beta 2 adrenergic receptors in bronchial smooth muscle and stimulates intracellular adenyl cyclase, thereby increasing the production of cyclic adenosine monophosphate (cAMP). Increased cAMP levels cause relaxation of bronchial smooth muscle, improve mucociliary clearance and reduce mediator substance release in inflammatory cells, especially from mast cells. (NCI05)
C47541	Fosfomycin_Tromethamine	Urinary_Anti-Infective_Agent	Fosfomycin Tromethamine|(1R,2S)-(1,2-Epoxypropyl)phosphonic Acid, compound with 2-Amino-2-(hydroxymethyl)-1,3-propanediol(1:1)|FOSFOMYCIN TROMETHAMINE|Fosfomycin Trometamol Salt|Fosfomycin compound with Trometamol|Monural	The tromethamine salt form of fosfomycin, a synthetic broad-spectrum antibiotic. Fosfomycin tromethamine binds to and inactivates the enzyme enolpyruvyl transferase. This leads to an irreversible blockage of the condensation of uridine diphosphate-N-acetylglucosamine with p-enolpyruvate, which is one of the first steps of bacterial cell wall synthesis, thereby eventually causing cell lysis. In addition, fosfomycin tromethamine reduces the adherence of bacteria to uroepithelial cells. (NCI05)
C47542	Fosinopril_Sodium	ACE_Inhibitor	Fosinopril Sodium|Eliten|FOSINOPRIL SODIUM|L-proline, 4-Cyclohexyl-1-[[[2-methyl-1-(1-oxopropoxy) propoxyl](4-phenylbutyl) phosphinyl]acetyl]-,Sodium Salt, trans-|Monopril|Newace	The sodium salt of fosinopril, a phosphinic acid-containing angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Fosinopril sodium is an ester prodrug that is hydrolysed by esterases to its active metabolite fosinoprilat. Fosinoprilat specifically and competitively inhibits angiotensin-converting enzyme thereby decreasing the formation of the potent vasoconstrictor angiotensin II, resulting in diminished vasopressor activity. In addition, angiotensin II-mediated aldosterone secretion by adrenal cortex is decreased, which results in a decrease of sodium retention and an increase of serum potassium. (NCI05)
C47543	Fosphenytoin_Sodium	Anticonvulsant_Agent	Fosphenytoin Sodium|2,4-Imidazolidinedione, 5,5-diphenyl-3-((phosphonooxy)methyl)-, Disodium Salt|Cerebryx|FOSPHENYTOIN SODIUM	The sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin upon parental administration. Phenytoin exerts its effect most likely through an enhancement of sodium efflux from neurons in the motor cortex. This leads to a suppression of excessive neuronal firing and spread of seizure activity. Other physiologic effects from actions of phenytoin include modulation of the voltage-dependent calcium channels of neurons, inhibition of calcium flux across neuronal membranes and enhancement of sodium-potassium ATPase activity of neurons and glial cells. (NCI05)
C47544	Frovatriptan_Succinate	Serotonin_Agonist	Frovatriptan Succinate|1H-Carbazole-6-carboxamide, 2,3,4,9-tetrahydro-3-(methylamino)-,(3R)-, Butanedioate(1:1)|FROVATRIPTAN SUCCINATE|Frova	The succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity. Frovatriptan succinate binds selectively and with high affinity to 5-HT 1B and presynaptic 5-HT 1D receptors in the extracerebral and intracranial arteries. This leads to an inhibition of serotonin activity and results in vasoconstriction of the painfully dilated blood vessels during migraine attack. Frovatriptan succinate is indicated for the acute treatment of migraine. (NCI05)
C47545	Gadoversetamide	Diagnostic_Reagent	Gadoversetamide|GADOVERSETAMIDE|Optimark	A paramagnetic extracellular magnetic resonance imaging (MRI) contrast agent that facilitates visualization of abnormal vascularity. When placed in a magnetic field, gadoversetamide decreases T1 (spin-lattice or longitudinal relaxation time) and T2 (spin-spin or transverse relaxation time) values in tissues where it accumulates. At the recommended dose, the effect is primarily on T1 relaxation time, and produces an increase in signal intensity. Gadoversetamide does not cross the intact blood-brain barrier. However, abnormal vascularity or disruption of the blood-brain barrier allows accumulation of gadoversetamide. (NCI05)
C47546	Galantamine_Hydrobromide	Acetylcholinesterase_Inhibitor	Galantamine Hydrobromide|Benzofuro(4,3,2-efg)(2)benzazocin-6-ol, 1,2,3,4,6,7,7a,11c-octahydro-9-methoxy-2-methyl-, Hydrobromide|GALANTAMINE HYDROBROMIDE|Lycoremine Hydrobromide|Nivalin|Reminyl	The hydrobromide salt form of galantamine, a tertiary alkaloid extracted from the bulbs of daffodil. Galantamine hydrobromide competitively and reversibly inhibits acetylcholinesterase, thereby increasing the concentration and enhancing the action of acetylcholine. Galantamine hydrobromide is used in the treatment of Alzheimer's disease. The effect may lessen as the disease progresses due to fewer cholinergic neurons remaining functionally intact. (NCI05)
C47547	Gallium_Citrate_Ga-67	Radioconjugate	Gallium Citrate Ga-67|1,2,3-Propanetricarboxylic Acid, 2-hydroxy-, Gallium-(sup 67)Ga(1:1) Salt|GALLIUM CITRATE, GA-67|Neoscan	A radioactive salt of gallium used as a radiopharmaceutical. The exact mechanism of action is unknown, but gallium citrate Ga-67 has been found to concentrate in certain viable primary and metastatic tumors as well as focal sites of inflammation. Adequate blood supply is essential for delivery of gallium citrate Ga-67 to the lesion. Gallium citrate Ga-67 is used as a diagnostic tool in neoplastic disease and inflammatory lesions. (NCI05)
C47548	Gemifloxacin_Mesylate	Quinolone_Antibiotic	Gemifloxacin Mesylate|7-((4Z)-3-(Aminomethyl)-4-methoxyiminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-(1,8)naphthyridine-3-carboxylic Acid Monomethanesulfonate|Factive|GEMIFLOXACIN MESYLATE	The mesylate salt form of gemifloxacin, a synthetic broad-spectrum fluoroquinolone with antibacterial activity. Gemifloxacin mesylate inhibits activities of DNA gyrase and topoisomerase IV, thereby inhibiting DNA replication and eventually bacterial growth. This fluoroquinolone exerts an enhanced spectrum of activity against gram-positive bacteria such as Streptococcus pneumoniae and Staphylococcus aureus, in addition to its activity against gram-negative bacteria.
C47549	Gluconolactone	Antioxidant	Gluconolactone|D-Gluconic Acid, delta-Lactone|D-Glucono-1,5-lactone|GLUCONOLACTONE	A naturally occurring polyhydroxy acid (PHA) with metal chelating, moisturizing and antioxidant activity. Gluconolactone can be produced by enzymatic oxidation of D-glucose oxidation. Its ability in free radicals scavenging accounts for its antioxidant property. It is used in cosmetic product and as a coagulant in tofu processing. (NCI05)
C47550	Guanfacine_Hydrochloride	Alpha-adrenergic_Agonist|Antihypertensive_Agent	Guanfacine Hydrochloride|Estulic|GUANFACINE HYDROCHLORIDE|N-(Aminoiminomethyl)-2,6-dichlorobenzeneacetamide Hydrochloride|Tenex	The hydrochloride salt form of guanfacine, a centrally acting alpha2-adrenergic agonist with antihypertensive activity. Alpha 2 receptor stimulation by guanfacine hydrochloride results in a decreased sympathetic outflow from the vasomotor center to the heart, kidneys, and peripheral vasculature. This leads to a decrease in heart rate and peripheral vascular resistance. (NCI05)
C47551	Guanidine_Hydrochloride	Cholinergic_Agonist	Guanidine Hydrochloride|Aminoformamidine Hydrochloride|GUANIDINE HYDROCHLORIDE	The hydrochloride salt form of guanidine, a strong basic compound with parasympathomimetic activity. Guanidine hydrochloride enhances the release of acetylcholine following a nerve impulse and potentiates acetylcholine actions on muscarinic and nicotinic receptors. It also appears to slow the rates of depolarization and repolarization of muscle cell membranes. (NCI05)
C47552	Halcinonide	Therapeutic_Glucocorticoid	Halcinonide|21-Chloro-9-fluoro-11beta,16alpha,17-trihydroxypregn-4-ene-3,20-dione Cyclic 16,17-Acetal with Acetone|HALCINONIDE|Halciderm|Halcort|Pregn-4-ene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))-,(11beta,16alpha)-|Volog	A topical, synthetic glucocorticoid with anti-inflammatory and anti-allergic properties. Halcinonide exerts its effect by interacting with specific intracellular receptors, and the ligand-receptor complex subsequently modulates gene expressions via the typical glucocorticoid signalling pathway. This results in the synthesis of certain anti-inflammatory proteins as well as in synthesis inhibition of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are accomplished. (NCI05)
C47553	Halobetasol_Propionate	Therapeutic_Glucocorticoid	Halobetasol Propionate|21-Chloro-6alpha,9-difluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate|HALOBETASOL PROPIONATE|Ultravate	The propionate salt form of halobetasol, a topical, synthetic corticosteroid with anti-inflammatory, antipruritic and vasoconstrictor activity. Halobetasol propionate exerts its effect via a typical glucocorticoid signalling pathway, binding to specific intracellular receptors and the ligand-receptor complex acts as gene expression modulator by binding to DNA sequences. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Consequently, an overall reduction in chronic inflammation and autoimmune reactions are accomplished. (NCI05)
C47554	Halothane	Anesthetic_Agent	Halothane|1,1,1-Trifluoro-2-bromo-2-chloroethane|HALOTHANE|Narcotan	A nonflammable, halogenated, hydrocarbon and general inhalation anesthetic. Although the exact mechanism of action is unknown, halothane provides relatively rapid induction of anesthesia by depressing the central nervous system, thereby producing a reversible loss of consciousness and sensation. (NCI05)
C47555	Hetacillin	Penicillin_Antibiotic	Hetacillin|6-(2,2-Dimethyl-5-oxo-4-phenyl-1-imidazolidinyl)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid|HETACILLIN|N,N'-Isopropylidene-A-amino-benzyl Penicillin|Phenazacillin	A semi-synthetic penicillin compound with bactericidal properties. Hetacillin is a prodrug that is converted to ampicillin. Ampicillin binds to inactivated penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs, including transpeptidases, carboxypeptidases, and endopeptidases, participate in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. This results in the weakening of the bacterial cell wall and eventually causes cell lysis. (NCI05)
C47556	Hexachlorophene	Topical_Anti-Infective_Agent	Hexachlorophene|2,2'-Methylenebis(3,4,6-trichlorophenol)|Bis(3,5,6-trichloro-2-hydroxyphenyl)-methane|Dermadex|HEXACHLOROPHENE|Phisohex|Septisol	A chlorinated bisphenol antiseptic agent with bacteriostatic activity. Hexachlorophene is used topically in soaps, creams and dermatological preparations and is active against gram-positive organisms, but much less effective against gram-negative organisms. (NCI05)
C47557	Hydroflumethiazide	Diuretic	Hydroflumethiazide|2H-1,2,4-Benzothiadiazine-7-sulfonamide, 3,4-dihydro-6-(trifluoromethyl)-, 1,1-Dioxide|Aquatensen|Diucardin|HYDROFLUMETHIAZIDE|Hydgroton|Saluron|Trifluoromethylhydrazide	A thiazide diuretic with antihypertensive activity. Hydroflumethiazide directly inhibits sodium and chloride reabsorption on the luminal membrane of the early segment of the distal convoluted tubule in the kidney. This results in an increase in water, sodium, chloride, potassium and bicarbonate excretion and a decrease in calcium and uric acid secretion. (NCI05)
C47558	Hydroxyamphetamine_Hydrobromide	Adrenergic_Agent	Hydroxyamphetamine Hydrobromide|HYDROXYAMPHETAMINE HYDROBROMIDE|Paredrine|Phenol, 4-(2-aminopropyl)-, Hydrobromide|Predrolon|beta-(p-Hydroxyphenyl)isopropylamine Hydrobromide	The hydrobromide salt form of hydroxyamphetamine with indirect-acting sympathomimetic activity. Hydroxyamphetamine hydrobromide releases norepinephrine from storage sites in adrenergic neurons. Upon topical administration in the eye, hydroxyamphetamine hydrobromide causes the release of endogenous norepinephrine from intact adrenergic nerve terminals, thereby constricting the iris sphincter muscle, resulting in mydriasis. In addition, hydroxyamphetamine hydrobromide is used topically as a nasal decongestant by constricting blood vessels of mucous membranes. (NCI05)
C47559	Hydroxyzine_Hydrochloride	Histamine-1_Receptor_Antagonist	Hydroxyzine Hydrochloride|1-(p-Chlorobenzhydryl)-4-(2-(2-hydroxyethoxy)ethyl)diethylenediamine Hydrochloride|Anxanil|Atarax|HYDROXYZINE HYDROCHLORIDE|Hyzine-50	The hydrochloride salt form of hydroxyzine, a piperazine histamine H1-receptor antagonist with anti-allergic, antispasmodic, sedative, anti-emetic and anti-anxiety properties. Hydroxyzine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. In addition, hydroxyzine hydrochloride crosses the blood-brain barrier and acts on the histamine H1-receptors in the central nervous system. (NCI05)
C47560	Hydroxyzine_Pamoate	Histamine-1_Receptor_Antagonist	Hydroxyzine Pamoate|2-Naphthoic Acid, 4,4'-methylenebis(3-hydroxy-, ester with 2-(2-(4-(p-chloro-alpha-phenylbenzyl)-1-piperazinyl)-ethoxy)ethanol|Atarax P|Ethanol, 2-(2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-, compound with 4,4'-Methylenebis(3-hydroxy-2-naphthalenecarboxylic Acid)(1:1)|HYDROXYZINE PAMOATE|Masmoran|Paxistil|Vistaril	The pamoate salt form of hydroxyzine, a synthetic piperazine histamine H1-receptor antagonist with anti-allergic, antispasmodic, sedative, anti-emetic and anti-anxiety properties. Hydroxyzine pamoate blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. In addition, hydroxyzine pamoate crosses the blood-brain barrier and acts on the histamine H1-receptors in the central nervous system. (NCI05)
C47561	Ibutilide_Fumarate	Antiarrhythmic_Agent	Ibutilide Fumarate|(+-)-4'-(4-(Ethylheptylamino)-1-hydroxybutyl)methanesulfonanilide Fumarate(2:1)(salt)|Corvert|IBUTILIDE FUMARATE	The fumarate salt form of ibutilide, a class III antiarrhythmic agent. Ibutilide exerts its effect by activating a slow, inward, predominately sodium current rather than by blocking outward potassium currents. This results in prolongation of atrial and ventricular action potential duration and refractory periods. Ibutilide slightly decreases the sinus rate and atrioventricular (AV) conduction and produces a dose-related prolongation of the QT interval. (NCI05)
C47562	Indium_In_111_Chloride	Radioconjugate	Indium In 111 Chloride|INDIUM IN 111 CHLORIDE|Indiclor|Indium Trichloride	A radioactive salt that is used as a reagent in the preparation of indium 111-labeled radiopharmaceuticals. Indium 111-labeled radioconjugates are used as radioactive tracers in nuclear medicine that detect malignant lesions and inflammatory tissues probably due to an increased capillary permeability. Indium-111 chloride is particularly used in the radiolabeling of the monoclonal antibodies satumomab pendetide, 7E11-C5.3 (CYT-356), and ibritumomab tiuxetan. (NCI05)
C47563	Insulin_Aspart_Recombinant	Therapeutic_Insulin	Insulin Aspart Recombinant|INSULIN ASPART RECOMBINANT|Novolog	A recombinant human insulin analog with rapid-acting, blood glucose-lowering activity. Insulin aspart, acting faster than regular human insulin, regulates glucose metabolism by binding to insulin receptors on muscle and fat cells, thereby facilitating the cellular uptake of glucose. This lowers blood glucose levels. At the same time, insulin aspart inhibits the liver's conversion of stored glycogen into glucose, which also contributes to lower blood glucose levels. Insulin aspart also inhibits lipolysis in adipose tissue, inhibits proteolysis, and enhances protein synthesis. (NCI05)
C47564	Insulin_Glargine_Recombinant	Therapeutic_Insulin	Insulin Glargine Recombinant|INSULIN GLARGINE RECOMBINANT|Lantus	A recombinant human insulin analog with long-acting, blood glucose-lowering activity. Insulin glargine, like regular types of human insulin, regulates glucose metabolism by binding to insulin receptors on muscle and fat cells, thereby facilitating the cellular uptake of glucose. This lowers blood glucose levels. At the same time, insulin glargine inhibits the liver's conversion of stored glycogen into glucose, which also contributes to lower blood glucose levels. Insulin glargine also inhibits lipolysis in adipose tissue, inhibits proteolysis, and enhances protein synthesis. (NCI05)
C47565	Iobenguane_Sulfate_I-131	Radioconjugate	Iobenguane Sulfate I-131|Guanidine,((3-(iodo-131I)phenyl)methyl)-, Sulfate(2:1)|IOBENGUANE SULFATE I 131
C47566	Iodipamide_Meglumine	Contrast_Agent	Iodipamide Meglumine|Adipiodone, Dimeglumine Salt|Benzoic Acid, 3,3'-((1,6-dioxo-1,6-hexanediyl)diimino)bis(2,4,6-triiodo-, compound with 1-Deoxy-1-(methylamino)-D-glucitol(1:2)|Biligrafin|Cholografin|Endografin|Glucitol, 1-deoxy-1-(methylamino)-, 3,3'-(adipoyldiimino)bis(2,4,6-triiodobenzoate)(2:1)(salt)|IODIPAMIDE MEGLUMINE	The meglumine salt form of iodipamide, an organic iodine compound and radiopaque contrast medium used for diagnostic tests. Iodipamide meglumine blocks x-rays, thereby allowing visualization of those structures that do not contain iodine. The degree of opacity is directly proportional to the total amount of this contrast agent in the path of the x-rays. Iodipamide meglumine is excreted through the hepato-biliary system and concentrated in bile which makes this contrast agent especially useful in the visualization of the gallbladder and biliary ducts. (NCI05)
C47567	Iopamidol	Contrast_Agent	Iopamidol|(S)-N,N'-bis(2-Hydroxy-1-(hydroxymethyl)ethyl)-2,4,6-triiodo-5-lactamidoisophthalamide|1,3-Benzenedicarboxamide, N,N'-bis(2-hydroxy-1-(hydroxymethyl)ethyl)-5-((2-hydroxy-1-oxopropyl)amino)-2,4,6-triiodo-|IOPAMIDOL|Isovue|Niopam|Solutrast	An organic iodine compound and used as a non-ionic water soluble radiographic contrast medium. Iopamidol blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by iopamidol is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of iopamidol. (NCI05)
C47568	Iothalamate_Meglumine	Contrast_Agent	Iothalamate Meglumine|1-Deoxy-1-(methylamino)-D-glucitol 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoate|Benzoic Acid, 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)-, compound with 1-Deoxy-1-(methylamino)-D-glucitol (1:1)|Conray|IOTHALAMATE MEGLUMINE|Iothalamic Acid N-Methylgucamine Salt|Meglumine Conray	The meglumine salt form of iothalamate, an organic iodine compound and a radiographic contrast medium. Iothalamate meglumine blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by iothalamate meglumine is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of iothalamate meglumine. (NCI05)
C47569	Iothalamate_Sodium	Contrast_Agent	Iothalamate Sodium|Angio-Conray|Benzoic Acid, 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)-, Monosodium Salt|IOTHALAMATE SODIUM|Isophthalamic Acid, 5-acetamido-2,4,6-triiodo-N-methyl-, Monosodium Salt|Mediocontrix	The sodium salt form of iothalamate, an organic iodine compound and a radiographic contrast medium. Iothalamate sodium blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by iothalamate sodium is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of iothalamate sodium. (NCI05)
C47570	Iothalamate_Sodium_I-125	Radioconjugate	Iothalamate Sodium I-125|Benzoic Acid, 3-(acetylamino)diiodoiodo-(sup 125)I-5-((methylamino)carbonyl)-, Monosodium Salt|Diatrizoate Sodium I 125|Glofil-125|IOTHALAMATE SODIUM, I-125|Monosodium 5-acetamido-triiodo-N-methylisophthalamate, labeled with Iodine-125
C47571	Ioxaglate_Meglumine	Contrast_Agent	Ioxaglate Meglumine|1-Deoxy-1-(methylamino)-D-glucitol 3-((((3-(acetylmethylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoyl)amino)acetyl)amino)-5-(((2-hydroxyethyl)amino)carbonyl)-2,4,6-triiodobenzoate|Benzoic Acid, 3-((((3-(acetylmethylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoyl)amino)acetyl)amino)-5-(((2-hydroxyethyl)amino)carbonyl)-2,4,6-triiodo-, compound with 1-deoxy-1-(methylamino)-D-glucitol(1:1)|IOXAGLATE MEGLUMINE	The meglumine salt form of ioxaglate, an organic iodine compound and a radiographic contrast medium. Ioxaglate meglumine blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by ioxaglate meglumine is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of ioxaglate meglumine. (NCI05)
C47572	Ioxaglate_Sodium	Contrast_Agent	Ioxaglate Sodium|Benzoic Acid, 3-((((3-(acetylmethylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoyl)amino)acetyl)amino)-5-(((2-hydroxyethyl)amino)carbonyl)-2,4,6-triiodo-, Monosodium Salt|IOXAGLATE SODIUM|Sodium N-(2-hydroxyethyl)-2,4,6-triiodo-5-(2-(2,4,6-triiodo-3-(N-methylacetamido)-5-(methylcarbamoyl)benzamido)acetamido)isophthalamate	The sodium salt form of ioxaglate, an organic iodine compound and a radiographic contrast medium. Ioxaglate sodium blocks x-rays as they pass through the body, thereby allowing body structures not containing iodine to be visualized. The degree of opacity produced by ioxaglate sodium is directly proportional to the total amount of the iodinated contrast agent in the path of the x-rays. The visualization of body structures is dependent upon the distribution and elimination of ioxaglate sodium. (NCI05)
C47573	Isocarboxazid	Monoamine_Oxidase_Inhibitor	Isocarboxazid|3-Isoxazolecarboxylic Acid, 5-methyl-, 2-(phenylmethyl)hydrazide|ISOCARBOXAZID|Marplan|Nardil|Parnate|Ro 5-0831	A hydralazine and monoamine oxidase (MAO) inhibitor with antidepressant activity. Isocarboxazid blocks the breakdown (oxidative deamination) of biogenic amines by inhibiting MAO, thereby increasing the concentrations of norepinephrine and 5-hydroxytrytamine (5-HT) at central aminergic receptors. These neurotransmitters are involved in sustaining mood and emotions. The down-regulation of central beta-adrenergic and serotonergic receptors by chronic inhibition of MAO may also contribute to the antidepressant effects seen by isocarboxazid. (NCI05)
C47575	Isosorbide_Mononitrate	Vasodilating_Agent	Isosorbide Mononitrate|1,4:3,6-Dianhydro-D-glucitol 5-nitrate|ISMO|ISOSORBIDE MONONITRATE|Imdur|Monoket|Monosordil	The mononitrate salt form of isosorbide, an organic nitrate with vasodilator activity. Isosorbide mononitrate relaxes vascular smooth muscle by formation of the free radical nitric oxide (NO), which is identical to the endothelium-derived relaxing factor (EDRF). NO activates guanylyl cyclase, thereby increasing the synthesis of cGMP within smooth muscle, resulting in dephosphorylation of light chain myosin and relaxation of peripheral arteries and veins. In addition, isosorbide mononitrate relaxes coronary arteries, thereby increasing the blood circulation through the ischemic area. (NCI05)
C47576	Isoxsuprine_Hydrochloride	Vasodilating_Agent	Isoxsuprine Hydrochloride|1-(p-Hydroxyphenyl)-2-(1'-methyl-2'-phenoxy)ethylaminopropanol-1 Hydrochloride|ISOXSUPRINE HYDROCHLORIDE|Norephedrine, p-hydroxy-N-(1-methyl-2-phenoxyethyl)-, Hydrochloride|Vasodilan	The hydrochloride salt form of isoxsuprine, a compound with vasodilator activity. Isoxsuprine hydrochloride directly acts on vascular and uterine smooth muscle, with little effect on cutaneous blood vessels, causing vascular and uterine smooth muscle relaxation. Its effects are thought to be due to beta-adrenergic receptor stimulation but are not reversed by beta-adrenergic blocking agents. This agent also causes cardiac stimulation by increasing heart rate and cardiac output. Isoxsuprine hydrochloride is used in the treatment of peripheral vascular disease and in the prevention of premature labour. (NCI05)
C47577	Isradipine	Antihypertensive_Agent|Calcium_Channel_Blocker	Isradipine|3,5-Pyridinedicarboxylic Acid, 4-(2,1,3-benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-, Methyl 1-methylethyl Ester|Dynacirc|ISRADIPINE|Isopropyl methyl(+-)-4-(4-benzofurazanyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate|Lomir	A dihydropyridine calcium channel blockers with antihypertensive and vasodilator activity. Isradipine blocks the calcium entry through the calcium ion channels of coronary and peripheral vascular smooth muscle, thereby dilating coronary arteries and peripheral arterioles. This increases oxygen delivery due to an increased blood flow and reduces oxygen requirements due to decrease in total peripheral resistance. (NCI05)
C47578	Ketoprofen	Nonsteroidal_Antiinflammatory_Drug	Ketoprofen|Benzeneacetic Acid, 3-benzoyl-alpha-methyl-|Capisten|KETOPROFEN|Orudis|Oruvail|Propionic Acid, 2-(3-benzoylphenyl)-	A propionic acid derivate and nonsteroidal anti-inflammatory drug (NSAID) with anti-inflammatory, analgesic and antipyretic effects. Ketoprofen inhibits the activity of the enzymes cyclo-oxygenase I and II, resulting in a decreased formation of precursors of prostaglandins and thromboxanes. The resulting decrease in prostaglandin synthesis, by prostaglandin synthase, is responsible for the therapeutic effects of ibuprofen. Ketoprofen also causes a decrease in the formation of thromboxane A2 synthesis, by thromboxane synthase, thereby inhibiting platelet aggregation.
C47579	Ketotifen_Fumarate	Histamine-1_Receptor_Antagonist	Ketotifen Fumarate|10H-Benzo(4,5)cyclohepta(1,2-b)thiophen-10-one, 4,9-dihydro-4-(1-methyl-4-piperidinylidene)-,(E)-2-butenedioate(1:1)|4-(1-Methyl-4-piperidylidene)-4H-benzo[4,5]cyclohepta[1,2-b] thiophen-10(9H)-one hydrogen fumarate|KETOTIFEN FUMARATE|Zaditen|Zaditor	The fumarate salt form of ketotifen, a cycloheptathiophene and relatively selective, non-competitive antihistamine H1 receptor antagonist and mast cell stabilizer with anti-allergic activity. Upon ocular administration, ketotifen fumarate blocks histamine h1 receptors and prevents the typical symptoms caused by histamine release. Ketotifen fumarate also interferes with the release of inflammatory mediators from cells involved in hypersensitivity reactions, thereby decreasing chemotaxis and activation of eosinophils.
C47580	Levalbuterol_Hydrochloride	Bronchodilator	Levalbuterol Hydrochloride|(-)-Salbutamol Hydrochloride|1,3-Benzenedimethanol, alpha1-(((1,1-dimethylethyl)amino)methyl)-4-hydroxy-, Hydrochloride,(alpha1R)-|LEVALBUTEROL HYDROCHLORIDE|Xopenex	The hydrochloride salt form of levalbuterol, a relatively selective sympathomimetic beta2 receptor agonist with bronchodilator activity. Levalbuterol hydrochloride binds to beta2-adrenergic receptors in bronchial smooth muscle and activates intracellular adenyl cyclase, thereby increasing the production of cyclic-3', 5'-adenosine monophosphate (cAMP). Increased cAMP levels lead to the activation of protein kinase A, which inhibits the phosphorylation of myosin and lowers intracellular ionic calcium concentrations, resulting in relaxation of bronchial smooth muscles. The increased cyclic AMP concentrations also inhibit the release of inflammatory mediators from mast cells.
C47581	Levetiracetam	Anticonvulsant_Agent	Levetiracetam|(S)-alpha-Ethyl-2-oxo-1-pyrrolidineacetamide|1-Pyrrolidineacetamide, Alpha-ethyl-2-oxo-,(S)-|Keppra|LEVETIRACETAM	A pyrrolidine with antiepileptic activity. The exact mechanism through which levetiracetam exerts its effects is unknown but does not involve inhibitory and excitatory neurotransmitter activity. Stereoselective binding of levetiracetam was confined to synaptic plasma membranes in the central nervous system with no binding occurring in peripheral tissue. Levetiracetam inhibits burst firing without affecting normal neuronal excitability, which suggests that it may selectively prevent hyper-synchronization of epileptiform burst firing and propagation of seizure activity.
C47582	Levocabastine_Hydrochloride	Histamine-1_Receptor_Antagonist	Levocabastine Hydrochloride|4-Piperidinecarboxylic Acid, 1-(4-cyano-4-(4-fluorophenyl)cyclohexyl)-3-methyl-4-phenyl-, Monohydrochloride,(-)-(1(cis)3alpha,4beta)-|LEVOCABASTINE HYDROCHLORIDE|Livostin|R 50,547	The hydrochloride salt form of levocabastine, a piperidine and potent histamine H1-receptor antagonist with anti-allergic properties without sedative effects. Levocabastine hydrochloride blocks the H1 histamine receptor and prevents the symptoms that are caused by histamine activity on capillaries, bronchial smooth muscle, and gastrointestinal smooth muscle, including vasodilatation, increased capillary permeability, bronchoconstriction, and spasmodic contraction of gastrointestinal smooth muscle. Levocabastine hydrochloride does not cross the blood-brain barrier and does not cause central nervous system effects.
C47583	Levomethadyl_Acetate_Hydrochloride	Opioid	Levomethadyl Acetate Hydrochloride|3-Heptanol, 6-(dimethylamino)-4,4-diphenyl-, Acetate (Ester), (3S,6S)-(-)-|Benzeneethanol, beta-(2-(dimethylamino)propyl)-alpha-ethyl-beta-phenyl-, Acetate(Ester)|LEVOMETHADYL ACETATE HYDROCHLORIDE|Orlaam|l-Acetylmethadol Hydrochloride
C47584	Levonordefrin	Adrenergic_Agent	Levonordefrin|(-)-alpha-(1-Aminoethyl)-3,4-dihydroxybenzyl Alcohol|1,2-Benzenediol, 4-(2-amino-1-hydroxypropyl)-,(R-(R*,S*))-|LEVONORDEFRIN|Neo-Cobefrin
C47585	Levonorgestrel	Oral_Contraceptive	Levonorgestrel|(17Alpha)-13-ethyl-17-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one|13-Ethyl-17-hydroxy-18,19-dinor-17alpha-pregn-4-en-20-yn-3-one|18-Methylnorethisterone|D-(-)-Norgestrel|LEVONORGESTREL|Norplant|Plan B
C47586	Levorphanol_Tartrate	Opioid	Levorphanol Tartrate|2H-10,4a-Iminoethanophenanthren-6-ol, 1,3,4,9,10,10a-hexahydro-11-methyl-, Tartrate|LEVORPHANOL TARTRATE|Lemoran|Levo-Dromoran|Morphinan-3-ol, 17-methyl-, Tartrate(1:1)(Salt)|Morphinan-3-ol, 17-methyl-,(2R,3R)-2,3-dihydroxybutanedioate(1:1)|NIH 4590|Ro 1-5431/7|l-3-Hydroxy-N-methylmorphinan Bitartrate	The tartrate salt form of levorphanol, a synthetic phenanthrene with potent opioid analgesic activity. Levorphanol tartrate mimics the actions of endogenous peptides at CNS opioid receptors, thereby producing the characteristic morphine-like effects on the mu-opioid receptor, including analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence.
C47587	Lomefloxacin_Hydrochloride	Quinolone_Antibiotic	Lomefloxacin Hydrochloride|(+-)-1-Ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid, monohydrochloride|LOMEFLOXACIN HYDROCHLORIDE|Maxaquin|Mazaquin|NY 198	The hydrochloride salt form of lomefloxacin, a synthetic broad-spectrum fluoroquinolone with antibacterial activity. Lomefloxacin hydrochloride inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. This inhibition leads to a decrease in DNA synthesis during bacterial replication, resulting in cell growth inhibition and eventually cell lysis.
C47588	Loracarbef	Cephalosporin_Antibiotic	Loracarbef|(6R, 7S)-7-[(R)-2-Amino-2-phenylacetamido]-3-chloro-8-oxo-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid, Monohydrate|LORACARBEF|Lorabid	A semi-synthetic, broad-spectrum, beta-lactamase resistant, second-generation cephalosporin antibiotic derived from cephasporium. The bactericidal activity of loracarbef results from the inhibition of bacterial cell wall synthesis through interference with the cross-linking of peptidoglycan units. This results in a reduction of cell wall stability and causes cell lysis. Loracarbef is more active against a variety of gram-negative organisms but less active against gram-positive pathogens compared to first-generation agents.
C47589	Loteprednol_Etabonate	Therapeutic_Glucocorticoid	Loteprednol Etabonate|Alrex|Androsta-1,4-diene-17-carboxylic Acid, 17-((ethoxycarbonyl)oxy)-11-hydroxy-3-oxo-, chloromethyl Ester,(11beta,17alpha)-|LOTEPREDNOL ETABONATE|Lotemax	The etabonate salt form of loteprednol, an ophthalmic analog of the corticosteroid prednisolone with anti-inflammatory activity. Loteprednol etabonate exerts its effect by interacting with specific intracellular receptors and subsequently binds to DNA to modify gene expression. This results in an induction of the synthesis of certain anti-inflammatory proteins while inhibiting the synthesis of certain inflammatory mediators. Loteprednol etabonate specifically induces phospholipase A2 inhibitory proteins (collectively called lipocortins), which inhibit the release of arachidonic acid, thereby inhibiting the biosynthesis of potent mediators of inflammation, such as prostaglandins and leukotrienes.
C47590	Loxapine_Succinate	Antipsychotic_Agent	Loxapine Succinate|2-Chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine Succinate(1:1)|Butanedioic Acid, compound with 2-Chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine(1:1)|Cloxazepin|Daxolin|LOXAPINE SUCCINATE|Lederle|Loxapac|Loxitane	The succinate salt form of loxapine, a tricyclic dibenzoxazepine antipsychotic agent with antiemetic, sedative, anticholinergic, and antiadrenergic actions. Loxapine succinate exerts its actions by blocking the dopamine receptors at postsynaptic receptor sites in the limbic system, cortical system and basal ganglia, thereby reducing the hallucinations and delusions that are associated with schizophrenia. This agent also exerts extrapyramidal side effects.
C47591	Mafenide_Acetate	Topical_Anti-Infective_Agent	Mafenide Acetate|4-(Aminomethyl)benzenesulfonamide Monoacetate|MAFENIDE ACETATE|Sulfamilon|Sulfamylon|alpha-Amino-p-toluenesulfonamide Monoacetate
C47592	Magnesium_Acetate	Nutritional_Supplement	Magnesium Acetate|Acetic Acid, Magnesium Salt|MAGNESIUM ACETATE
C47593	Malathion	Pediculocide	Malathion|Butanedioic Acid,((dimethoxyphosphinothioyl)thio)-, Diethyl Ester|MALATHION|Ovide|Succinic Acid, mercapto-, Diethyl Ester, S-ester with O,O-Dimethylphosphorodithioate
C47594	Maprotiline_Hydrochloride	Antidepressant_Agent	Maprotiline Hydrochloride|1-(3-Methylaminopropyl)dibenzo(b,e)bicyclo(2.2.2)octadiene Hydrochloride|9-(gamma-Methylaminopropyl)-9,10-dihydro-9,10-ethanoanthracene Hydrochloride|Ludiomil|MAPROTILINE HYDROCHLORIDE
C47595	Mebendazole	Antihelminthic_Agent	Mebendazole|(5-Benzoyl-1H-benzimidazol-2-yl)-carbamic Acid Methyl Ester|MEBENDAZOLE|Methyl 5-benzoyl benzimidazole-2-carbamate|R 17635|Vermox
C47596	Meclocycline_Sulfosalicylate	Tetracycline_Antibiotic	Meclocycline Sulfosalicylate|(4S,4aR,5S,5aR,12aS)-7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-2-naphthacenecarboxamide Mono(5-sulfosalicylate)(Salt)|MECLOCYCLINE SULFOSALICYLATE|Meclan|Mecloderm
C47597	Meclofenamate_Sodium	Nonsteroidal_Antiinflammatory_Drug	Meclofenamate Sodium|Benzoic Acid, 2-((2,6-dichloro-3-methylphenyl)amino)-, Monosodium Salt|MECLOFENAMATE SODIUM|Meclomen|Meclonax|Sodium 2-((2,6-dichloro-3-methylphenyl)amino)benzoate
C47598	Medrysone	Therapeutic_Glucocorticoid	Medrysone|11-beta-Hydroxy-6-alpha-methylpregn-4-ene-3,20-dione|6-alpha-Methyl-11-beta-hydroxyprogesterone|MEDRYSONE
C47599	Mefenamic_Acid	Nonsteroidal_Antiinflammatory_Drug	Mefenamic Acid|2-((2,3-Dimethylphenyl)amino)benzoic Acid|Anthranilic Acid, N-2,3-xylyl-|MEFENAMIC ACID|Ponstel
C47600	Mefloquine_Hydrochloride	Antimalarial_Agent	Mefloquine Hydrochloride|DL-erythro-alpha-2-Piperidyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol Monohydrochloride|Lariam|MEFLOQUINE HYDROCHLORIDE|Mephaquin|Ro 21-5998/001
C47601	Memantine_Hydrochloride	Antiparkinsonian_Agent	Memantine Hydrochloride|1-amino-3,5-dimethyladamantane Hydrochloride|Ebixia|MEMANTINE HYDROCHLORIDE|Namenda
C47602	Mepivacaine_Hydrochloride	Anesthetic_Agent	Mepivacaine Hydrochloride|(1-Methyl-DL-piperidine-2-carboxylic acid)-2,6-dimethylanilide hydrochloride|1-Methyl-2',6'-pipecoloxylidide Monohydrochloride|Carbocaine|MEPIVACAINE HYDROCHLORIDE
C47603	Meprobamate	Muscle_Relaxant	Meprobamate|1,3-Propanediol, 2-methyl-2-propyl-, Dicarbamate|Equanil|MEPROBAMATE|Meprospan|Miltown|Miltown 600|Neuramate
C47604	Mequinol	Miscellaneous_Adjuvant	Mequinol|4-Methoxyphenol|4-hydroxyanisole|Hydroquinone Monomethyl Ether|MEQUINOL
C47605	Metaproterenol_Sulfate	Bronchodilator	Metaproterenol Sulfate|1,3-Benzenediol, 5-(1-hydroxy-2-((1-methylethyl)amino)ethyl)-, Sulfate(2:1)(Salt)|3,5-Dihydroxy-alpha-((isopropylamino)methyl)benzyl Alcohol Sulfate|Alupent|METAPROTERENOL SULFATE|Novasmasol
C47606	Metaxalone	Muscle_Relaxant	Metaxalone|2-Oxazolidinone, 5-((3,5-dimethylphenoxy)methyl)-|METAXALONE|Skelaxin|Zorane
C47607	Methacholine_Chloride	Diagnostic_Reagent	Methacholine Chloride|1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, Chloride|Amechol|Ammonium,(2-hydroxypropyl)trimethyl-, Chloride, Acetate|METHACHOLINE CHLORIDE|Provocholine
C47608	Methacycline_Hydrochloride	Tetracycline_Antibiotic	Methacycline Hydrochloride|2-Naphthacenecarboxamide, 4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-, Monohydrochloride,(4S-(4alpha,4aalpha,5alpha,5aalpha,12aalpha))-|METHACYCLINE HYDROCHLORIDE|Optimycin|Rindex|Rondomycin
C47609	Methamphetamine_Hydrochloride	CNS_Stimulant	Methamphetamine Hydrochloride|Benzeneethanamine, N,alpha-dimethyl-, Hydrochloride(9CI)|Desoxyn|METHAMPHETAMINE HYDROCHLORIDE|N,alpha-Dimethylphenethylamine Hydrochloride|N-methyl-1-phenyl-propan-2-amine|d-N-Methyl-beta-phenylisopropylamine Hydrochloride
C47610	Methenamine_Hippurate	Urinary_Anti-Infective_Agent	Methenamine Hippurate|Glycine, N-benzoyl, compound with 1,3,5,7-tetraazatricyclo(3.3.1.1(sup 3,7))decane(1:1)|Hexamethylene Tetramine Hippurate|Hippramine|METHENAMINE HIPPURATE|Urex|Viapta
C47611	Methicillin_Sodium	Penicillin_Antibiotic	Methicillin Sodium|4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-((2,6-dimethoxybenzoyl)amino)-3,3-dimethyl-7-oxo-, Monosodium Salt, Monohydrate,(2S-(2alpha,5alpha,6beta))-|Celbenin|METHICILLIN SODIUM|Staphcillin
C47612	Methscopolamine_Bromide	Antimuscarinic_Agent	Methscopolamine Bromide|1-alpha-H,5-alpha-H-Tropanium, 6-beta,7-beta-epoxy-3-alpha-hydroxy-8-methyl-, Bromide,(-)-tropate(ester)|1alphaH,5alphaH-Tropanium, 6beta,7beta-epoxy-3alpha-hydroxy-8-methyl-, bromide,(-)-tropate(8CI)|METHSCOPOLAMINE BROMIDE|Pamine
C47613	Methsuximide	Anticonvulsant_Agent	Methsuximide|1,3-Dimethyl-3-phenyl-2,5-dioxopyrrolidine|Celontin|METHSUXIMIDE|Succinimide, N,2-dimethyl-2-phenyl-
C47614	Methyclothiazide	Diuretic	Methyclothiazide|2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(chloromethyl)-3,4-dihydro-2-methyl-, 1,1-Dioxide|Aquatensen|Enduron|METHYCLOTHIAZIDE|Naturon
C47615	Methyl_Methacrylate	Biomaterials	Methyl Methacrylate|2-(Methoxycarbonyl)propene|2-Methyl Acrylic Acid Methyl Ester|2-Methylmethacrylate|2-Propenoic Acid, 2-methyl-, Methyl Ester|Diakon|METHYL METHACRYLATE|MMA|Methyl 2-Methyl-2-propenoate|Pegalan
C47616	Methyldopa	Antihypertensive_Agent	Methyldopa|3-Hydroxy-alpha-methyl-L-tyrosine|Aldomet|Amodopa|Dopamet|L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic Acid|Levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine|METHYLDOPA
C47617	Methyldopate_Hydrochloride	Antihypertensive_Agent	Methyldopate Hydrochloride|Aldomet Ester Hydrochloride|L-3-(3,4-Dihydroxyphenyl)-2-methylalanine Ethyl Ester Hydrochloride|L-Tyrosine, 3-hydroxy-alpha-methyl-, Ethyl Ester, Hydrochloride|METHYLDOPATE HYDROCHLORIDE|Methyldopa Ethyl Ester Hydrochloride
C47618	Methylergonovine_Maleate	Serotonin_Agonist	Methylergonovine Maleate|Ergoline-8-carboxamide, 9,10-didehydro-N-((1S)-1-(hydroxymethyl)propyl)-6-methyl-,(8beta)-,(2Z)-2-butenedioate(1:1)(salt)|METHYLERGONOVINE MALEATE|Maleic Acid, Methyl Ergonovine|Methergine
C47619	Metyrapone	Diagnostic_Reagent	Metyrapone|1-Propanone, 2-methyl-1,2-di-3-pyridinyl-|METYRAPONE|Metopirone
C47620	Midodrine_Hydrochloride	Alpha-adrenergic_Agonist	Midodrine Hydrochloride|(+-)-2-Amino-N-(beta-hydroxy-2,5-dimethoxyphenethyl)acetamide Monohydrochloride|1-(2',5'-Dimethoxyphenyl)-2-glycinamidoethanol Hydrochloride|Amatine|Gutron|MIDODRINE HYDROCHLORIDE|Midamine|ProAmantine
C47622	Minocycline_Hydrochloride	Tetracycline_Antibiotic	Minocycline Hydrochloride|4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride|Dynacin|MINOCYCLINE HYDROCHLORIDE|Minocin|Minomax|Minomycin|Tri-minocycline|Vectrin
C47623	Minoxidil	Antihypertensive_Agent|Vasodilating_Agent	Minoxidil|2,3-Dihydro-3-hydroxy-2-imino-6-(1-piperidinyl)-4-pyrimidinamine|2,4-Pyrimidinediamine, 6-(1-Piperidinyl)-, 3-Oxide|Alostil|Loniten|MINOXIDIL|Rogaine|U 10858
C47624	Molindone_Hydrochloride	Antipsychotic_Agent	Molindone Hydrochloride|4H-Indol-4-one, 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-, Monohydrochloride|Lidone|MOLINDONE HYDROCHLORIDE|Moban
C47625	Montelukast_Sodium	Anti-asthmatic_Agent	Montelukast Sodium|Cyclopropaneacetic Acid, 1-((((1R)-1-(3-((1E)-2-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)-, Monosodium Salt|MK 476|MONTELUKAST SODIUM|Singulair
C47626	Moricizine_Hydrochloride	Antiarrhythmic_Agent	Moricizine Hydrochloride|Carbamic Acid,(10-(3-(4-morpholinyl)-1-oxopropyl)-10H-phenothiazin-2-yl)-, Ethyl Ester, Monohydrochloride|Ethmozine|Ethyl 10-(3-morpholinopropionyl)phenothiazine-2-carbamate hydrochloride|MORICIZINE HYDROCHLORIDE
C47627	Nabumetone	Nonsteroidal_Antiinflammatory_Drug	Nabumetone|4-(6-Methoxy-2-naphthalenyl)-2-butanone|NABUMETONE|Relafen
C47628	Naftifine_Hydrochloride	Antifungal_Agent	Naftifine Hydrochloride|(E)-N-methyl-N-(1-naphthylmethyl)-3-phenyl-2-propen-1-amine-hydrochloride|NAFTIFINE HYDROCHLORIDE|Naftin|SN 105843
C47629	Nalbuphine_Hydrochloride	Opioid	Nalbuphine Hydrochloride|(5alpha,6alpha)-17-(Cyclobutylmethyl)-4,5-epoxymorphinan-3,6,14-triol Hydrochloride|N-Cyclobutylmethyl-14-hydroxydihydronormorphine Hydrochloride|NALBUPHINE HYDROCHLORIDE|Nubain
C47630	Nalidixic_Acid	Quinolone_Antibiotic|Urinary_Anti-Infective_Agent	Nalidixic Acid|1,8-Naphthyridine-3-carboxylic Acid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-|3-Carboxy-1-ethyl-7-methyl-1,8-naphthidin-4-one|NALIDIXIC ACID|Nalidixin|NegGram
C47631	Nalmefene_Hydrochloride	Opiate_Antagonist	Nalmefene Hydrochloride|Morphinan-3,14-diol, 17-(cyclopropylmethyl)-4,5-epoxy-6-methylene-, Hydrochloride,(5alpha)-|NALMEFENE HYDROCHLORIDE|Revex
C47632	Naphazoline_Hydrochloride	Alpha-adrenergic_Agonist	Naphazoline Hydrochloride|1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)-, Monohydrochloride|2-(1-Naphthylmethyl)-2-imidazoline Hydrochloride|Albalon|NAPHAZOLINE HYDROCHLORIDE|Nafazair|Opcon|Vasocon
C47633	Naratriptan_Hydrochloride	Serotonin_Agonist	Naratriptan Hydrochloride|Amerge|GR 85548A|N-methyl-3-( 1-methyl-4-piperidinyl)-1H-indole-5-ethanesulfonamide Monohydrochloride|NARATRIPTAN HYDROCHLORIDE
C47634	Natamycin	Antifungal_Agent	Natamycin|16-(3-Amino-3,6-didesoxy-beta-D-mannopyranosyloxy)-5,6-epoxy-8,12,14-trihydroxy-26-methyl-2,10-dioxo-1-oxacyclohexacosa-3,17,19,21,23-pentaen-13-carbonsaeure|Delvolan|Myprozine|NATAMYCIN|Natacyn|Pimaricin|Synogil
C47635	Nedocromil_Sodium	Nonsteroidal_Antiinflammatory_Drug	Nedocromil Sodium|4H-Pyrano[3,2-g]quinoline-2,8-dicarboxylic Acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, Disodium Salt|Alocril|FPL 59002KP|NEDOCROMIL SODIUM|Tilade
C47636	Nesiritide	Vasodilating_Agent	Nesiritide|1,2-Dithia-5,8,11,14,17,20,23,26,29,32,35,38,41,44,47,50-hexadecaazacyclotripentacontane, Cyclic Peptide Derivative|Human Brain Natriuretic Factor-32|L-Histidine, L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminylglycyl-L-serylglycyl-L-cysteinyl-L-phenylalanylglycyl-L_arginyl-L-lysyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-serylglycyl-L-leucylglycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-, Cyclic (10-26)-disulfide|NESIRITIDE|Natrecor|Natriuretic Peptide Type-B|Natriuretic factor-32
C47637	Nitazoxanide	Antiprotozoal_Agent	Nitazoxanide|Alinia|Benzamide, 2-(acetyloxy)-N-(5-nitro-2-thiazolyl)-|NITAZOXANIDE|Salicylamide, N-(5-nitro-2-thiazolyl)-, Acetate(Ester)
C47638	Norfloxacin	Quinolone_Antibiotic	Norfloxacin|1,4-Dihydro-1-ethyl-6-fluoro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid|Baccidal|Fulgram|MK-366|NORFLOXACIN|Noroxin|Sebercim
C47639	Olanzapine	Antipsychotic_Agent	Olanzapine|2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno(2,3-b)(1,5)benzodiazepine|LY 170053|OLANZAPINE|Zydis|Zyprexa
C47640	Olmesartan_Medoxomil	Antihypertensive_Agent	Olmesartan Medoxomil|1H-Imidazole-5-carboxylic Acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-,(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl Ester|Benicar|CS 866|OLMESARTAN MEDOXOMIL
C47641	Orphenadrine_Citrate	Muscle_Relaxant	Orphenadrine Citrate|Ethanamine, N,N-dimethyl-2-((2-methylphenyl)phenyl)methoxy)-, 2-hydroxy-1,2,3-propanetricarboxylate(1:1)|Norflex|ORPHENADRINE CITRATE
C47642	Oxazepam	Benzodiazepine	Oxazepam|2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-3-hydroxy-5-phenyl-|OXAZEPAM|Ro 5-6789|Serax|Seresta|Wy 3498
C47643	Oxcarbazepine	Anticonvulsant_Agent	Oxcarbazepine|10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide|OXCARBAZEPINE|Trileptal
C47644	Oxiconazole_Nitrate	Antifungal_Agent	Oxiconazole Nitrate|(Z)-1-(2-(2,4-Dichlorophenyl)-2-(((2,4-dichlorophenyl)oxy)imino)ethyl)-1H-imidazole Mononitrate|Ethanone, 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-, O-((2,4-dichlorophenyl)methyl)oxime,(Z)-, Mononitrate|OXICONAZOLE NITRATE|Oxistat
C47645	Oxtriphylline	Bronchodilator	Oxtriphylline|Choledyl|Choline, hydroxide, compound with Theophylline(1:1)|Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, salt with 3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione(1:1)|OXTRIPHYLLINE|Zy 15061
C47646	Oxybenzone	Sunscreen	Oxybenzone|2-Hydroxy-4-methoxybenzophenone|2-Hydroxy-4-methoxybenzophenone,[2-Hydroxy-4-methoxyphenyl]phenylmethanone|Anuvex|Benzophenone-3|OXYBENZONE
C47647	Oxybutynin	Antispasmotic_Agent	Oxybutynin|4-Diethylamino-2-butynyl alpha-phenylcyclohexaneglycolate|Benzeneacetic Acid, alpha-cyclohexyl-alpha-hydroxy-, 4-(diethylamino)-2-butynyl Ester|Ditropan|OXYBUTYNIN|Oxytrol
C47648	Oxymorphone_Hydrochloride	Opioid	Oxymorphone Hydrochloride|4,5-alpha-Epoxy-3,14-dihydroxy-17-methylmorphinan-6-one Hydrochloride|Numorphan|OXYMORPHONE HYDROCHLORIDE
C47649	Oxytetracycline_Hydrochloride	Tetracycline_Antibiotic	Oxytetracycline Hydrochloride|(4S,4aR,5S,5aR,6S,12aS)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,5,6,10,12,12a-hexahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide, Monohydrochloride|5-Hydroxytetracycline Hydrochloride|Alamycin|Dalinmycin|OXYTETRACYCLINE HYDROCHLORIDE|Terramycin
C47650	Palonosetron_Hydrochloride	Antiemetic_Agent	Palonosetron Hydrochloride|1H-Benz(de)isoquinolin-1-one, 2-(3S)-1-azabicyclo(2.2.2)oct-3-yl-2,3,3a,4,5,6-hexahydro-, Monohydrochloride,(3aS)-|Aloxi|PALONOSETRON HYDROCHLORIDE|RS 25259-197
C47651	Pancuronium_Bromide	Muscle_Relaxant	Pancuronium Bromide|2beta,16beta-Dipiperidino-5alpha-androstane-3alpha,17beta-diol Diacetate Dimethobromide|PANCURONIUM BROMIDE|Pavulon|Piperidinium, 1,1'-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)androstane-2,16-diyl)bis(1-methyl)-, Dibromide
C47652	Paromomycin_Sulfate	Aminoglycoside_Antibiotic	Paromomycin Sulfate|Aminosidine Sulfate|D-Streptamine, O-2-amino-2-deoxy-alpha-D-glucopyranosyl-(1->4)-O-(O-2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl-(1->3)-beta-D-ribofuranosyl-(1->5))-2-deoxy-, Sulfate(salt)|Humatin|Humycin sulfate|PAROMOMYCIN SULFATE
C47653	Paroxetine_Mesylate	Antidepressant_Agent	Paroxetine Mesylate|PAROXETINE MESYLATE|Paroxetine Methanesulfonate|Pexeva|Piperidine, 3-((1,3-benzodioxol-5-yloxy)methyl)-4-(4-fluorophenyl)-,(3S,4R)-, Methanesulfonate
C47654	Pemirolast_Potassium	Mast_Cell_Stabilizer	Pemirolast Potassium|4H-Pyrido(1,2-a)pyrimidin-4-one, 9-methyl-3-(1H-tetrazol-5-yl)-, Potassium Salt|Alamast|PEMIROLAST POTASSIUM|Pemilaston
C47655	Pemoline	CNS_Stimulant	Pemoline|2-Imino-4-keto-5-phenyltetrahydrooxazole|4(5H)-Oxazolone, 2-amino-5-phenyl-|5-Phenylisohydantion|Cylert|PEMOLINE
C47656	Penciclovir_Sodium	Nucleic_Acid_Synthesis_Inhibitor	Penciclovir Sodium|1,9-Dihydro-2-amino-9-(4-hydroxy-3-(hydroxymethyl)butyl)-6H-purin-6-one Monosodium Salt|9-(4-Hydroxy-3-(hydroxymethyl)butyl)guanine, Monosodium Salt|Denavir|PENCICLOVIR SODIUM
C47657	Penicillin_G_Benzathine	Penicillin_Antibiotic	Penicillin G Benzathine|PENICILLIN G BENZATHINE
C47658	Penicillin_G_Potassium	Penicillin_Antibiotic	Penicillin G Potassium|4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-(2-phenylacetamido)-, Monopotassium Salt|Benzylpenicillinic Acid Potassium Salt|Capicillin|PENICILLIN G POTASSIUM|Sugracillin|Tabilin
C47660	Pentaerythritol_Tetranitrate	Vasodilating_Agent	Pentaerythritol Tetranitrate|1,3-Dinitrato-2,2-bis(nitratomethyl)propane|1,3-Propanediol, 2,2-bis((nitrooxy)methyl)-, Dinitrate(ester)|PENTAERYTHRITOL TETRANITRATE|Pentafin|Peritrate|Vasolat
C47661	Pentazocine_Hydrochloride	Opioid	Pentazocine Hydrochloride|2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(3-methyl-2-butenyl)-, Hydrochloride, (2R,6R,11R)-rel-|PENTAZOCINE HYDROCHLORIDE|Talwin
C47662	Pentobarbital_Sodium	Sedative_and_Hypnotic	Pentobarbital Sodium|2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-Ethyl-5-(1-methylbutyl), Monosodium Salt|Barbituric Acid, 5-ethyl-5-(1-methylbutyl)-,Sodium Salt|Barpental|Mebumal Sodium|Nembutal|PENTOBARBITAL SODIUM|Pental
C47663	Perflexane	Diagnostic_Reagent	Perflexane|AF0150|Flutec PP1|Imagent|Imavist|PERFLEXANE|Perfluoro-n-hexane|Tetradecafluorohexane
C47664	Perflutren	Diagnostic_Reagent	Perflutren|Definity|Freon 218|Octafluoropropane|Optison|PERFLUTREN|Perfluoropropane
C47665	Pergolide_Mesylate	Antiparkinsonian_Agent	Pergolide Mesylate|8B-[(Methylthio)methyl]-6-propylergoline Monomethanesulfonate|LY127809|PERGOLIDE MESYLATE|Permax
C47666	Perindopril_Erbumine	ACE_Inhibitor	Perindopril Erbumine|1H-Indole-2-carboxylic Acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-,(2S-(1(R*(R*))2alpha,3abeta,7abeta))-, compound with 2-Methyl-2-propanamine(1:1)|Aceon|PERINDOPRIL ERBUMINE
C47667	Phendimetrazine_Tartrate	Anorexiant|CNS_Stimulant	Phendimetrazine Tartrate|(2S,3S)-3,4-Dimethyl-2-phenylmorpholine L-(+)-tartrate(1:1)|Adipost|Bontril|Morpholine, 3,4-dimethyl-2-phenyl-,(2S,3S)-,(2R,3R)-2,3-dihydroxybutanedioate(1:1)|PHENDIMETRAZINE TARTRATE|Plegine|Statobex
C47668	Phenelzine_Sulfate	Monoamine_Oxidase_Inhibitor	Phenelzine Sulfate|2-Phenylethylhydrazine Hydrogen Sulphate|2-Phenylethylhydrazine Sulphate|Nardil|PHENELZINE SULFATE
C47669	Phenyltoloxamine	Histamine-1_Receptor_Antagonist	Phenyltoloxamine|Antin|Bristamin|Histionex|N,N-Dimethyl-2-(2-(phenylmethyl)phenoxy)ethanamine|N,N-Dimethyl-2-(alpha-phenyl-o-tolyloxy)ethylamine|PHENYLTOLOXAMINE
C47670	Phosphoric_Acid	Reagent	Phosphoric Acid|Orthophosphoric Acid|PHOSPHORIC ACID|o-Phosphoric Acid
C47671	Pimecrolimus	Immunosuppressant	Pimecrolimus|15,19-Epoxy-3H-pyrido(2,1-c)(1,4)oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone, 3-((1E)-2-((1R,3R,4S)-4-chloro-3-methoxycyclohexyl)-1-methylethenyl)-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-,(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-|33-epi-Chloro-33-desoxyascomycin|Elidel|PIMECROLIMUS
C47672	Pimozide	Antipsychotic_Agent	Pimozide|2H-Benzimidazol-2-one, 1-(1-(4,4-bis(4-fluorophenyl)butyl)-4-piperidinyl)-1,3-dihydro-|Opiran|Orap|PIMOZIDE
C47673	Pindolol	Beta-Adrenergic_Blocking_Agent	Pindolol|1-(1H-Indol-4-yloxy)-3-((1-methylethyl)amino)-2-propanol|Carvisken|PINDOLOL|Visken
C47674	Piperazine_Citrate	Antihelminthic_Agent	Piperazine Citrate|Antepar|PIPERAZINE CITRATE|Piperazine, 2-hydroxy-1,2,3-propanetricarboxylate(3:2)|Pipralen|Pripsen
C47675	Pirbuterol_Acetate	Bronchodilator	Pirbuterol Acetate|Maxair|PIRBUTEROL ACETATE|alpha(sup 6)-((tert-Butylamino)methyl)-3-hydroxy-2,6-pyridinedimethanol Monoacetate(salt)
C47676	Polythiazide	Diuretic	Polythiazide|2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-2-methyl-3-(((2,2,2-trifluoroethyl)thio)methyl)-, 1,1-Dioxide|Drenusil|Nephril|POLYTHIAZIDE|Renese
C47677	Potassium_Acetate	Electrolyte_Replacement_Agent	Potassium Acetate|Acetic Acid, Potassium Salt|FEMA No. 2920|POTASSIUM ACETATE|Potassium Ethanoate
C47678	Potassium_Aminosalicylate	Antitubercular_Agent	Potassium Aminosalicylate|Benzoic Acid, 4-amino-2-hydroxy-, Monopotassium Salt|POTASSIUM AMINOSALICYLATE|Paskalium|Potassium 4-aminosalicylate
C47679	Potassium_Chloride	Electrolyte_Replacement_Agent	Potassium Chloride|Cena-K|K-Lor|Klorvess|Klotrix|POTASSIUM CHLORIDE|Potasalan|Slow-K
C47680	Potassium_Iodide	Radioprotective_Agent	Potassium Iodide|POTASSIUM IODIDE|Pima|Potassium Salt of Hydriodic Acid|Thyro-Block
C47681	Potassium_Perchlorate	Antithyroid_Agent	Potassium Perchlorate|Astrumal|Irenal|POTASSIUM PERCHLORATE|Perchloric Acid, Potassium Salt
C47682	Pramoxine_Hydrochloride	Anesthetic_Agent	Pramoxine Hydrochloride|4-(3-(p-Butoxyphenoxy)propyl)morpholine Hydrochloride|Fleet|PRAMOXINE HYDROCHLORIDE|Tronolane|Tronothane
C47683	Praziquantel	Antihelminthic_Agent	Praziquantel|4H-Pyrazino(2,1-a)isoquinolin-4-one, 2-(cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-|Biltricide|Droncit|PRAZIQUANTEL
C47684	Prednicarbate	Therapeutic_Glucocorticoid|Topical_Anti-Infective_Agent	Prednicarbate|Dermatop|PREDNICARBATE|Pregna-1,4-diene-3,20-dione, 17-((ethoxycarbonyl)oxy)-11-hydroxy-21-(1-oxopropoxy)-,(11beta)-
C47685	Prilocaine	Anesthetic_Agent	Prilocaine|PRILOCAINE|Propanamide, N-(2-methylphenyl)-2-(propylamino)-(9CI)|Propitocaine|o-Methyl-alpha-propylaminopropionanilide|o-Propionotoluidide, 2-(propylamino)-
C47686	Primidone	Anticonvulsant_Agent	Primidone|2-Deoxyphenobarbital|4,6(1H,5H)-Pyrimidinedione, 5-ethyldihydro-5-phenyl-|Myidone|Mysedon|Mysoline, Apo-Primidone|Neurosyn|PRIMIDONE|Primaclone
C47687	Procainamide_Hydrochloride	Antiarrhythmic_Agent	Procainamide Hydrochloride|Benzamide, 4-amino-N-(2-(diethylamino)ethyl)-, Monohydrochloride|Novocamid Hydrochloride|PROCAINAMIDE HYDROCHLORIDE|Procan SR|Promine|Pronestyl|Pronestyl-SR
C47688	Procaine_Hydrochloride	Anesthetic_Agent	Procaine Hydrochloride|2-(Diethylamino)ethyl p-aminobenzoate Monohydrochloride|Allocaine|Benzoic Acid, 4-amino-, 2-(diethylamino)ethyl Ester, Monohydrochloride|Gerovital H3|Novocain|PROCAINE HYDROCHLORIDE
C47689	Procyclidine_Hydrochloride	Antiparkinsonian_Agent	Procyclidine Hydrochloride|1-Pyrrolidinepropanol, alpha-cyclohexyl-alpha-phenyl-, Hydrochloride|1-cyclohexyl-1-phenyl-3-pyrrolidino-1-propanol Hydrochloride|Kemadrin|PROCYCLIDINE HYDROCHLORIDE|Tricyclamol Hydrochloride
C47690	Proguanil_Hydrochloride	Antimalarial_Agent	Proguanil Hydrochloride|1-(p-Chlorophenyl)-5-isopropylbiguanide Hydrochloride|Bigumalum|Chlorguanide|Chloriguane|Chloroquanil|Imidodicarbonimidic Diamide, N-(4-chlorophenyl)-N'-(1-methylethyl)-, Monohydrochloride(9CI)|PROGUANIL HYDROCHLORIDE|Proguanil hydrochloride
C47691	Promazine_Hydrochloride	Antipsychotic_Agent	Promazine Hydrochloride|10-(3-(Dimethylamino)propyl)phenothiazine Monohydrochloride|10H-Phenothiazine-10-propanamine, N,N-dimethyl-, Monohydrochloride|PROMAZINE HYDROCHLORIDE|Sparine|Starazin|Talofen
C47692	Propafenone_Hydrochloride	Antiarrhythmic_Agent	Propafenone Hydrochloride|1-Propanone, 1-(2-(2-hydroxy-3-(propylamino)propoxy)phenyl)-3-phenyl-, Hydrochloride|2'-(2-Hydroxy-3-(propylamino)propoxy)-3-phenylpropiophenone Hydrochloride|Baxarytmon|PROPAFENONE HYDROCHLORIDE|Rythmol
C47693	Proparacaine_Hydrochloride	Anesthetic_Agent	Proparacaine Hydrochloride|2-(Diethylamino)ethyl 3-amino-4-propoxybenzoate Monohydrochloride|Alcaine|Benzoic Acid, 3-amino-4-propoxy-, 2-(diethylamino)ethyl Ester, Hydrochloride|Keracaine|Ophthetic|PROPARACAINE HYDROCHLORIDE
C47694	Propylhexedrine	Alpha-adrenergic_Agonist	Propylhexedrine|(+-)-N,alpha-Dimethylcyclohexaneethylamine|1-Cyclohexyl-2-(methylamino)propane|Dristan|Hydromethamphetamine|PROPYLHEXEDRINE
C47695	Protriptyline_Hydrochloride	Antidepressant_Agent	Protriptyline Hydrochloride|5H-Dibenzo(a,d)cycloheptene-5-propanamine, N-methyl-, Hydrochloride|Concordin|MK-240|Maximed|PROTRIPTYLINE HYDROCHLORIDE|Triptil Hydrochloride|Vivactil
C47696	Pseudoephedrine_Sulfate	Adrenergic_Agent|Alpha-adrenergic_Agonist	Pseudoephedrine Sulfate|Afrin|Afrinol|Benzenemethanol, alpha-((1S)-1-(methylamino)ethyl)-, (alphaS)-,Sulfate (2:1) (salt)|D-Isoephedrine Sulfate|PSEUDOEPHEDRINE SULFATE|Pseudophedrine Sulfate
C47697	Pyridostigmine_Bromide	Acetylcholinesterase_Inhibitor	Pyridostigmine Bromide|3-(((Dimethylamino)carbonyl)oxy)-1-methylpyridinium Bromide|3-Hydroxy-1-methylpyridinium Bromide Dimethylcarbamate|Carbamic Acid,Dimethyl-, Ester with 3-Hydroxy-1-methylpyridinium Bromide|Kalimin|Mestinon Bromide|PYRIDOSTIGMINE BROMIDE|Regonal
C47698	Pyrithione_Zinc	Anti-psoriatic_Agent|Antifungal_Agent	Pyrithione Zinc|2-Mercaptopyridine 1-oxide Zinc Salt|Bis(1-hydroxy-2(1H)-pyridinethionato)zinc|PYRITHIONE ZINC|Zinc Pyridine-2-thiol 1-oxide|Zinc, bis(1-hydroxy-2(1H)-pyridinethionato)-|Zinc, bis(2-pyridylthio)-, N,N'-dioxide
C47699	Quazepam	Benzodiazepine	Quazepam|2H-1,4-Benzodiazepine-2-thione, 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-1-(2,2,2-trifluoroethyl)-|Dormalin|QUAZEPAM|Selepam
C47700	Quetiapine_Fumarate	Antipsychotic_Agent	Quetiapine Fumarate|Ethanol, 2-(2-(4-dibenzo(b,f)(1,4)thiazepin-11-yl-1-piperazinyl)ethoxy)-,(E)-2-butenedioate(2:1)(salt)|QUETIAPINE FUMARATE|Seroquel
C47701	Quinupristin	Antibiotic	Quinupristin|N-((6R,9S,10R,13S,15aS,18R,22S,24aS)-22-(p-(Dimethylamino)benzyl)-6-ethyldocosahydro-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyl-18-(((3S)-3-quinuclidinylthio)methyl)-12H-pyrido(2,1-f)pyrrolo(2,1-l)(1,4,7,10,13,16)oxapentaazacyclononadecin-9-yl)-3-hydroxypicolinamide|QUINUPRISTIN|Virginiamycin S1, 4-(4-(dimethylamino)-N-methyl-L-phenylalanine)-5-(5-((1-azabicyclo(2.2.2)oct-3-ylthio)methyl)-4-oxo-L-2-piperidinecarboxylic Acid)-,(S)-
C47702	Remifentanil_Hydrochloride	Opioid	Remifentanil Hydrochloride|1-Piperidinepropanoic Acid, 4-(methoxycarbonyl)-4-((1-oxopropyl)phenylamino)-, Methyl Ester, Monohydrochloride|REMIFENTANIL HYDROCHLORIDE|Ultiva
C47703	Repaglinide	Anti-diabetic_Agent	Repaglinide|(+)-2-Ethoxy-alpha-(((S)-alpha-isobutyl-o-piperidinobenzyl)carbamoyl)-p-toluic Acid|AG-EE 623 ZW|Benzoic Acid, 2-ethoxy-4-(2-((3-methyl-1-(2-(1-piperidinyl)phenyl)butyl)amino)-2-oxoethyl)-,(S)-|Prandin|REPAGLINIDE
C47704	Riluzole	Anticonvulsant_Agent	Riluzole|2-Amino-6-(trifluoromethoxy)benzothiazole|RILUZOLE|Rilutek
C47705	Rimexolone	Therapeutic_Glucocorticoid	Rimexolone|(11beta,16alpha,17beta)-11-Hydroxy-16,17-dimethyl-17-(1-oxopropyl)androsta-1,4-dien-3-one|RIMEXOLONE|Vexol
C47706	Ritodrine_Hydrochloride	Beta-adrenergic_Agonist	Ritodrine Hydrochloride|Erythro-p-Hydroxy-alpha-(1-((p-hydroxyphenethyl)amino)ethyl)benzyl Alcohol Hydrochloride|Pre-Par|RITODRINE HYDROCHLORIDE|Yutopar
C47707	Rivastigmine_Tartrate	Acetylcholinesterase_Inhibitor	Rivastigmine Tartrate|Carbamic Acid, Ethylmethyl-, 3-((1S)-1-(dimethylamino)ethyl)phenyl Ester,(2R,3R)-2,3-dihydroxybutanedioate(1:1)|Exelon|RIVASTIGMINE TARTRATE|SDZ-ENA 713
C47708	Rizatriptan_Benzoate	Serotonin_Agonist	Rizatriptan Benzoate|1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-, Monobenzoate|L 705,126|Maxalt|RIZATRIPTAN BENZOATE
C47709	Rocuronium_Bromide	Muscle_Relaxant	Rocuronium Bromide|ORG 9426|Pyrrolidinium, 1-((2beta,3alpha,5alpha,16beta,17beta)-17-(acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl)-1-(2-propenyl)-, Bromide|ROCURONIUM BROMIDE|Zemuron
C47710	Ropinirole_Hydrochloride	Antiparkinsonian_Agent	Ropinirole Hydrochloride|2(H)-Indol-2-one, 4-(2-(dipropylamino)ethyl)-1,3-dihydro-, Monohydrochloride|4-(2-(Dipropylamino)ethyl)-2-indolinone Monohydrochloride|ROPINIROLE HYDROCHLORIDE|Requip|SK&F 101468-A
C47711	Rubidium_Chloride_Rb-82	Radioconjugate	Rubidium Chloride Rb-82|Cardiogen|RUBIDIUM CHLORIDE RB-82
C47712	Scopolamine	Antimuscarinic_Agent	Scopolamine|1alphaH,5alphaH-Tropan-3alpha-ol, 6beta,7beta-epoxy-,(-)-tropate(ester)|6,7-Epoxytropine Tropate|6beta,7beta-Epoxy-3alpha-tropanyl S-(-)-tropate|Atrochin|Benzeneacetic Acid, alpha-(hydroxymethyl)-,(1alpha,2beta,4beta,5alpha,7beta)-9-methyl-3-oxa-9-azatricyclo(3.3.1.02,4)non-7-yl ester,(alphaS)-|Epoxytropine Tropate|Hyoscine|SCOPOLAMINE
C47713	Secretin_Synthetic_Human	Diagnostic_Reagent	Secretin Synthetic Human|RG1068|SECRETIN SYNTHETIC HUMAN|SHS
C47714	Selegiline_Hydrochloride	Monoamine_Oxidase_Inhibitor	Selegiline Hydrochloride|(-)-Phenylisopropylmethylpropynylamine|Benzeneethanamine, N,alpha-dimethyl-N-2-propynyl-, Hydrochloride,(R)-|Eldepryl Hydrochloride|SELEGILINE HYDROCHLORIDE|l-deprenyl Hydrochloride
C47715	Sermorelin_Acetate	Miscellaneous_Hormone_Agent	Sermorelin Acetate|29-L-Argininamide-30-de-L-glutamine-31-de-L-glutamine-32-deglycine-33-de-L-glutamic acid-34-de-L-serine-35-de-L-asparagine-36-de-L-glutamine-37-de-L-glutamic acid-38-de-L-arginine-39-deglycine-40-de-L-alanine-41-de-L-arginine-42-de-L-alanine-43-de-L-arginine-44-de-L-leucinamide Growth Hormone-releasing Factor, Acetate (salt), Hydrate|29-L-argininamide-30-de-L-glutamine-31-de-L-glutamine-32-deglycine-33-de-L-glutamic acid-34-de-L-serine-35-de-L-asparagine-36-de-L-glutamine-37-de-L-glutamic acid-38-de-L-arginine-39-deglycine-40-de-L-alanine-41-de-L-arginine-42-de-L-alanine-43-de-L-arginine-44-de-L-leucinamide-, Acetate(salt)|Geref|Growth hormone-releasing Factor (Human)-(1-29)-peptide Amide, Acetate (Salt), Hydrate|SERMORELIN ACETATE
C47716	Sertaconazole_Nitrate	Antifungal_Agent	Sertaconazole Nitrate|1H-Imidazole, 1-(2-((7-chlorobenzo(b)thien-3-yl)methoxy)-2-(2,4-dichlorophenyl)ethyl)-, Mononitrate|Dermofix|Ertaczo|SERTACONAZOLE NITRATE|Zalain
C47717	Sevoflurane	Anesthetic_Agent	Sevoflurane|1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane|Ether, Fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl-|SEVOFLURANE|Ultane
C47718	Sibutramine_Hydrochloride	Antidepressant_Agent	Sibutramine Hydrochloride|BTS 54524|Cyclobutanemethanamine, 1-(4-chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)-, Hydrochloride|HSDB 7209|Meridia|SIBUTRAMINE HYDROCHLORIDE
C47719	Sincalide	Diagnostic_Reagent	Sincalide|1-De(5-oxo-L-proline)-2-de-L-glutamine-5-L-methioninecaerulein|Kinevac|L-Aspartyl-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-aspartylphenyl-L-alaninamide Hydrogen Sulfate(ester)|L-alpha-Aspartyl-O-sulfo-L-tyrosyl-L-methionylglycyl-L-tryptophyl-L-methionyl-L-alpha-aspartyl-L-phenylalaninamide|SINCALIDE
C47720	Sodium_Acetate	Electrolyte_Replacement_Agent	Sodium Acetate|Acetic Acid, Sodium Salt|SODIUM ACETATE
C47721	Sodium_Carbonate	Essential_Minor_Component_of_Pharmaceutical_Excipient	Sodium Carbonate|Carbonic Acid, Disodium Salt|SODIUM CARBONATE
C47722	Sodium_Chromate_Cr-51	Radioconjugate	Sodium Chromate Cr-51|Chromic-51Cr Acid, Disodium Salt|Natrium radio-chromicum(51Cr)|SODIUM CHROMATE, CR-51|Sodium Chromate(VI) 51Cr-labeled Compound
C47723	Sodium_Gluconate	Chelating_Agent	Sodium Gluconate|D-Gluconic Acid, Monosodium Salt|Glonsen|Gluconic Acid Sodium Salt|SODIUM GLUCONATE
C47724	Sodium_Iodide_I-123	Sodium_Iodide_Radioactive	Sodium Iodide I-123|(123-I)Sodium Iodide|SODIUM IODIDE, I-123
C47725	Sodium_Iodide_I-131	Sodium_Iodide_Radioactive	Sodium Iodide I-131|(131-I)Sodium Iodide|Iodotope I-131|Natrium Radio-iodatum(131 I)|Oriodide|Radiocaps-131|SODIUM IODIDE, I-131
C47726	Sodium_Lactate	Electrolyte_Replacement_Agent	Sodium Lactate|2-Hydroxypropanoic Acid Sodium Salt|Lacolin|Lactic Acid, Sodium Salt|Per-glycerin|SODIUM LACTATE|Sodium alpha-Hydroxypropionate
C47727	Sodium_Sulfate	Electrolyte_Replacement_Agent	Sodium Sulfate|Bisodium Sulfate|Disodium Sulfate|Disodium Sulfate Decahydrate|SODIUM SULFATE|Sulfuric Acid Disodium Salt, Decahydrate
C47728	Spectinomycin_Hydrochloride	Aminoglycoside_Antibiotic	Spectinomycin Hydrochloride|4H-Pyrano(2,3-b)(1,4)benzodioxin-4-one, decahydro-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)-, Dihydrochloride,(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-|SPECTINOMYCIN HYDROCHLORIDE|Spectinomycin Dihydrochloride|Spectinomycin Hydrochloride Anhydrous|Spectogard|Trobicin
C47729	Streptomycin_Sulfate	Aminoglycoside_Antibiotic	Streptomycin Sulfate|Bis-(4-O-(2-O-(2-desoxy-2-methylamino-alpha-L-glucopyranosyl)-alpha-L-streptosyl)-L-streptidin)-trisulfat|D-Streptamine, O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-, Sulfate(2:3)(salt)|STREPTOMYCIN SULFATE|Streptomycin Sesquisulfate
C47730	Succinylcholine_Chloride	Muscle_Relaxant	Succinylcholine Chloride|Anectine|Dichloride|Ethanaminium, 2,2'-((1,4-dioxo-1,4-butanediyl)bis(oxy))bis(N,N,N-trimethyl-)|Quelicin|SUCCINYLCHOLINE CHLORIDE
C47731	Sufentanil_Citrate	Opioid	Sufentanil Citrate|Fentatienil|N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)-N-phenylpropionamide Citrate|N-(4-(Methoxymethyl)-1-(2-(2-thienyl)ethyl)-4-piperidyl)propionanilide Citrate|Propanamide, N-(4-(methoxymethyl)-1-(2-(thienyl)ethyl)-4-piperidinyl)-N-phenyl-, 2-hydroxy-1,2,3-propanetricarboxylate(1:1)|SUFENTANIL CITRATE|Sufenta
C47732	Sulbactam_Sodium	Beta-Lactam_Antibiotic	Sulbactam Sodium|4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 3,3-dimethyl-7-oxo-, 4,4-dioxide, Sodium Salt,(2S-cis)-|Penicillanic Acid 1,1-dioxide, Sodium Salt|SULBACTAM SODIUM|Sodium(2S,5R)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate 4,4-Dioxide
C47733	Sulconazole_Nitrate	Antifungal_Agent	Sulconazole Nitrate|(+-)-1-(2,4-Dichloro-beta-((4-chlorobenzyl)thio)phenethyl)imidazole Nitrate|1H-Imidazole, 1-(2-(((4-chlorophenyl)methyl)thio)-2-(2,4-dichlorophenyl)ethyl)-, Mononitrate,(+-)-|Exelderm|SULCONAZOLE NITRATE
C47734	Sulfacytine	Sulfonamide_Anti-infective_Agent	Sulfacytine|1-Ethyl N4-sulfanilylcytosin|Benzenesulfonamide, 4-amino-N-(1-ethyl-1,2-dihydro-2-oxo-4-pyrimidinyl)-|Renoquid|SULFACYTINE|Sulfanilamide, N1-(1-ethyl-1,2-dihydro-2-oxo-4-pyrimidinyl)-(8CI)
C47735	Sulfadoxine	Antimalarial_Agent	Sulfadoxine|Benzenesulfonamide, 4-amino-N-(5,6-dimethoxy-4-pyrimidinyl)-|Fansidar|N'-(5,6-Dimethoxy-4-pyrimidyl)sulfanilamide|SULFADOXINE
C47736	Sulfamethizole	Sulfonamide_Anti-infective_Agent	Sulfamethizole|2-(p-Aminobenzenesulfonamido)-5-methylthiadiazole|Benzenesulfonamide, 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)-|Gantanol|Gantrisin|SULFAMETHIZOLE|Sulfanilamide, N(sup 1)-(5-methyl-1,3,4-thiadiazol-2-yl)-|Thiosulfil Forte|Urobak
C47737	Sulfamethoxazole	Sulfonamide_Anti-infective_Agent	Sulfamethoxazole|Bactrim|Bactrimel|Benzenesulfonamide, 4-amino-N-(5-methyl-3-isoxazolyl)-|Gamazole|Gentanol|Metoxal|Radonil|SULFAMETHOXAZOLE|Sulfanilamide, N'-(5-methyl-3-isoxazolyl)-|Sulfisomezole
C47738	Sulfanilamide	Sulfonamide_Anti-infective_Agent	Sulfanilamide|4-Aminobenzenesulfonamide|4-Sulfamoylaniline|AVC|SULFANILAMIDE|Sultrin|Trysul
C47739	Sulfinpyrazone	Uricosuric_Agent	Sulfinpyrazone|3,5-Pyrazolidinedione, 1,2-diphenyl-4-(2-(phenylsulfinyl)ethyl)-|Anturane|Enturen|SULFINPYRAZONE
C47740	Sulfisoxazole	Sulfonamide_Anti-infective_Agent	Sulfisoxazole|Benzenesulfonamide, 4-amino-N-(3,4-dimethyl-5-isoxazolyl)-|Gantrisin|SULFISOXAZOLE
C47741	Sulfisoxazole_Acetyl	Sulfonamide_Anti-infective_Agent	Sulfisoxazole Acetyl|Acetamide, N-((4-aminophenyl)sulfonyl)-N-(3,4-dimethyl-5-isoxazolyl)-|Lipo Gantrisin|N-3,4-Dimethylisoxazol-5-yl-N-sulphanilylacetamide|SULFISOXAZOLE ACETYL
C47742	Tacrine_Hydrochloride	Acetylcholinesterase_Inhibitor	Tacrine Hydrochloride|1,2,3,4-tetrahydro-9-acridinamine Monohydrochloride Monohydrate|Cognex|Hydroaminacrine|TACRINE HYDROCHLORIDE|Tenakrin
C47743	Tadalafil	Phosphodiesterase_Inhibitor	Tadalafil|(6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione|Cialis|Ic351|TADALAFIL
C47744	Tartaric_Acid	Antioxidant	Tartaric Acid|2,3-Dihydroxybutanedioic Acid|2,3-Dihydroxysuccinic Acid|TARTARIC ACID|Tartrate
C47745	Technetium_Tc-99m_Apcitide	Radioconjugate	Technetium Tc-99m Apcitide|TECHNETIUM TC-99M APCITIDE
C47746	Telmisartan	Antihypertensive_Agent	Telmisartan|(1,1'-Biphenyl)-2-carboxylic Acid, 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-|4'-((4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic Acid|BIBR 277|Micardis|TELMISARTAN
C47747	Tenofovir_Disoproxil_Fumarate	Reverse_Transcriptase_Inhibitor	Tenofovir Disoproxil Fumarate|9-((R)-2-((Bis(((isopropoxycarbonyl)oxy)methoxy)phosphinyl)methoxy)propyl)adenine, Fumarate|TDF|TENOFOVIR DISOPROXIL FUMARATE|Viread
C47748	Terbutaline_Sulfate	Bronchodilator	Terbutaline Sulfate|(+-)-alpha-((tert-Butylamino)methyl)-3,5-dihydroxybenzyl Alcohol Sulfate(2:1)(salt)|1,3-Benzenediol, 5-(2-((1,1-dimethylethyl)amino)-1-hydroxyethyl)-, Sulfate(2:1)(salt)|1-(3,5-Dihydroxyphenyl)-2-tert-butylaminoethanol Sulphate|Brethaire|Brethancer|Bretine|Bricanyl|TERBUTALINE SULFATE
C47749	Tetrahydrozoline_Hydrochloride	Alpha-adrenergic_Agonist	Tetrahydrozoline Hydrochloride|1H-Imidazole, 4,5-dihydro-2-(1,2,3,4-tetrahydro-1-naphthalenyl)-, Monohydrochloride|2-(1,2,3,4-Tetrahydro-1-naphthyl)-2-imidazoline Hydrochloride|TETRAHYDROZOLINE HYDROCHLORIDE|Tyzanol Hydrochloride|Tyzine|Vasopos|Visine
C47750	Thallous_Chloride_Tl-201	Radioconjugate	Thallous Chloride Tl-201|(201-Tl) Thallous Chloride|THALLOUS CHLORIDE, TL-201|Thallium-201 Chloride
C47751	Thimerosal	Preservative_Excipient|Topical_Anti-Infective_Agent	Thimerosal|((o-Carboxyphenyl)thio)ethylmercury, Sodium Salt|Ethyl(2-mercaptobenzoato-S)mercury, Sodium Salt|Ethylmercurithiosalicylate Sodium|Mercurate(1-), Ethyl(2-mercaptobenzoato(2-)-O,S)-, Sodium|Mercury, ethyl(hydrogen o-mercaptobenzoato)-, Sodium Salt(8CI)|Merthiolate Sodium|Sodium Ethylmercurithiosalicylate|THIMEROSAL
C47752	Thiothixene	Antipsychotic_Agent	Thiothixene|9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-|N,N-Dimethyl-9-(3-(4-methylpiperazin-1-yl)propylidene)-9H-thioxanthene-2-sulphonamide|Navane|Navaron|Orbinamon|P-4657 B|THIOTHIXENE|Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-
C47753	Thiothixene_Hydrochloride	Antipsychotic_Agent	Thiothixene Hydrochloride|9H-Thioxanthene-2-sulfonamide, N,N-dimethyl-9-(3-(4-methyl-1-piperazinyl)propylidene)-, Dihydrochloride, Dihydrate|CP 12252-1|Navane Hydrochloride|THIOTHIXENE HYDROCHLORIDE
C47754	Thonzonium_Bromide	Surfactant_Excipient	Thonzonium Bromide|1-Hexadecanaminium, N-(2-(((4-methoxyphenyl)methyl)-2-pyrimidinylamino)ethyl)-N,N-dimethyl-, Bromide|Ammonium, hexadecyl(2-((p-methoxybenzyl)-2-pyrimidinylamino)ethyl)dimethyl-, Bromide(8CI)|THONZONIUM BROMIDE
C47755	Tiagabine_Hydrochloride	Anticonvulsant_Agent	Tiagabine Hydrochloride|(-)-(R)-1-(4,4-Bis(3-methyl-2-thienyl)-3-butenyl)nipecotic Acid, Hydrochloride|3-Piperidinecarboxylic Acid, 1-(4,4-bis(3-methyl-2-thienyl)-3-buten-yl)-, Hydrochloride,(R)-|Gabritril|NNC-05-0328|TIAGABINE HYDROCHLORIDE
C47756	Ticlopidine_Hydrochloride	Antiplatelet_Agent	Ticlopidine Hydrochloride|5-(o-Chlorobenzyl)-4,5,6,7-tetrahydrothieno(3,2-c)pyridinium Chloride|Panaldine|TICLOPIDINE HYDROCHLORIDE|Thieno(3,2-c)pyridine, 5-((2-chlorophenyl)methyl)-4,5,6,7-tetrahydro-, Hydrochloride|Ticlid|Ticlodix|Ticlodone
C47757	Timolol	Beta-Adrenergic_Blocking_Agent	Timolol|(S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol|2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-,(2S)-|Blocadren|TIMOLOL
C47758	Tiopronin	Miscellaneous_Adjuvant	Tiopronin|(2-Mercaptopropionyl)glycine|Glycine, N-(2-mercapto-1-oxopropyl)-|TIOPRONIN|Thiola|Thiolpropionamidoacetic Acid
C47759	Tirofiban_Hydrochloride	Antiplatelet_Agent	Tirofiban Hydrochloride|Aggrastat|MK 383|N-(Butylsulfonyl)-O-(4-(4-piperidinyl)butyl)-L-tyrosine Monohydrochloride|TIROFIBAN HYDROCHLORIDE
C47760	Tizanidine_Hydrochloride	Muscle_Relaxant	Tizanidine Hydrochloride|2,1,3-Benzothiadiazol-4-amine, 5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-, Monohydrochloride|5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole Hydrochloride|TIZANIDINE HYDROCHLORIDE|Zanaflex
C47761	Tocainide_Hydrochloride	Antiarrhythmic_Agent	Tocainide Hydrochloride|Propanamide, 2-amino-N-(2,6-dimethylphenyl)-, Monohydrochloride|TOCAINIDE HYDROCHLORIDE|Taquidil|Tonocard|Xylotocan
C47762	Tolcapone	Antiparkinsonian_Agent	Tolcapone|3,4-dihydroxy-4'-methyl-5-nitrobenzophenone|Methanone,(3,4-dihydroxy-5-nitrophenyl)(4-methylphenyl)-|TOLCAPONE|Tasmar
C47763	Tolnaftate	Antifungal_Agent	Tolnaftate|Absorbine|Aftate|Carbamothioic Acid, methyl(3-methylphenyl)-, O-2-naphthalenyl Ester|Carbanilic Acid, m,N-dimethylthio-, O-2-naphthyl Ester|Desenex|Focusan|Genaspor|NP 27|TOLNAFTATE|Tinactin|Tolsanil
C47764	Topiramate	Anticonvulsant_Agent	Topiramate|TOPIRAMATE|Topamax|beta-D-Fructopyranose, 2,3:4,5-bis-O-(1-methylethylidene)-, Sulfamate
C47765	Tranexamic_Acid	Miscellaneous_Adjuvant	Tranexamic Acid|Amicar|Cyclohexanecarboxylic Acid, 4-(aminomethyl)-, trans-|Cyclokapron|TRANEXAMIC ACID
C47766	Travoprost	Anti-glaucoma_Agent	Travoprost|5-Heptenoic Acid, 7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((1E,3R)-3-hydroxy-4-(3-(trifluoromethyl)phenoxy)-1-butenyl)cyclopentyl)-, 1-methylethyl Ester,(5Z)-|AL-6221|TRAVOPROST|Travatan
C47767	Trazodone_Hydrochloride	Antidepressant_Agent	Trazodone Hydrochloride|1,2,4-Triazolo(4,3-a)pyridin-3(2H)-one, 2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-, Monohydrochloride|2-(3-(4-(3-Chlorophenyl)piperazin-1-y)propyl)-1,2,4-triazolo(4,3-a)pyridine-3(2H)-one Hydrochloride|Desyrel|TRAZODONE HYDROCHLORIDE|Trialodine
C47768	Tribromsalan	Topical_Anti-Infective_Agent	Tribromsalan|3,5-Dibromo-N-(4-bromophenyl)-2-hydroxybenzamide|Agramed|Salicylanilide, 3,4',5-tribromo-|TRIBROMSALAN|Temacept|Trisanil
C47769	Trichlormethiazide	Diuretic	Trichlormethiazide|2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3-(dichloromethyl)-3,4-dihydro-, 1,1-Dioxide|3-Dichloromethylhydrochlorothiazide|Hygroton|Metahydrin|Naqua|TRICHLORMETHIAZIDE|Triclordiuride
C47770	Triclocarban	Topical_Anti-Infective_Agent	Triclocarban|3,4,4'-Trichlorodiphenylurea|Carbanilide, 3,4,4'-trichloro-|N-(4-Chlorophenyl)-N'-(3,4-dichlorophenyl)urea|TCC|TRICLOCARBAN|Triclorocarbanilide
C47771	Trihexyphenidyl_Hydrochloride	Antiparkinsonian_Agent	Trihexyphenidyl Hydrochloride|1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-, Hydrochloride|Artane|Cyclodol|TRIHEXYPHENIDYL HYDROCHLORIDE
C47772	Trimethadione	Anticonvulsant_Agent	Trimethadione|2,4-Oxazolidinedione, 3,5,5-trimethyl-|TRIMETHADIONE|Tridione
C47773	Trimipramine_Maleate	Antidepressant_Agent	Trimipramine Maleate|5H-Dibenz(b,f)azepine, 10,11-dihydro-5-(3-(dimethylamino)-2-methylpropyl)-, Maleate(1:1)|5H-Dibenz(b,f)azepine-5-propanamine, 10,11-Dihydro-N,N,beta-trimethyl-,(Z)-2-Butenedioate(1:1)|Rhotrimine|Surmontil|TRIMIPRAMINE MALEATE
C47774	Tripelennamine_Hydrochloride	Histamine-1_Receptor_Antagonist	Tripelennamine Hydrochloride|1,2-Ethanediamine, N,N-dimethyl-N'-(phenylmethyl)-N'-2-pyridinyl-, Monohydrochloride|NIH 10186|Piristin|Pyridine, 2-(benzyl(2-(dimethylamino)ethyl)amino)-, Monohydrochloride|TRIPELENNAMINE HYDROCHLORIDE
C47775	Tromethamine	Reagent	Tromethamine|1,3-Propanediol, 2-Amino-2-(hydroxymethyl)-|Aminotrimethylolmethane|TRIS|TROMETHAMINE|Tris Buffer|Tris(hydroxymethyl)aminomethane|Tris(hydroxymethyly)amino Methane|Tris-base|Trometamol
C47776	Tropicamide	Diagnostic_Reagent	Tropicamide|Benzeneacetamide, N-ethyl-alpha-(hydroxymethyl)-N-(4-pyridinylmethyl)-|Mydral|Mydriacyl|N-Ethyl-2-phenyl-N-(4-pyridylmethyl)hydracrylamide|Opticyl|Ro 1-7683|TROPICAMIDE|Tropicacyl|Tropimil|l-Picamide
C47777	Tubocurarine_Chloride	Muscle_Relaxant	Tubocurarine Chloride|13H-4,6:21,24-Dietheno-8,12-metheno-1H-pyrido(3',2':14,15)(1,11)dioxacycloeicosino(2,3,4-ij)isoquinolinium|2,3,13a,14,15,16,25,25a-Octahydro-9,19-dihydroxy-18,29-dimethoxy-1,14,14-trimethyl-, Chloride, Hydrochloride,(13aR,25aS)-|Amerizol|TUBOCURARINE CHLORIDE|Tubocuraranium, 7',12'-Dihydroxy-6,6'-dimethoxy-2,2',2'-trimethyl-, Chloride, Hydrochloride|Tubocurare
C47778	Unoprostone_Isopropyl	Anti-glaucoma_Agent	Unoprostone Isopropyl|Isopropyl (+)-( Z )-7-[(1 R, 2 R, 3 R, 5 S )-3,5-dihydroxy-2-(3-oxodecyl) Cyclopentyl]-5-heptenoate|Rescula|UNOPROSTONE ISOPROPYL
C47779	Urea_C-13	Diagnostic_Reagent	Urea C-13|C13 Urea|UREA, C-13
C47780	Urea_C-14	Diagnostic_Reagent	Urea C-14|C14 Urea|UREA, C-14
C47781	Valsartan	Antihypertensive_Agent	Valsartan|CGP 48933|Diovan|L-Valine, N-(1-oxopentyl)-N-((2'-(1H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-|N-(p-(o-1H-Tetrazol-5-ylphenyl)benzyl)-N-valeryl-L-valine|VALSARTAN
C47782	Vecuronium_Bromide	Muscle_Relaxant	Vecuronium Bromide|NC-45|Norcuron|Piperidinium, 1-((2beta,3alpha,5alpha,16beta,17beta)-3,17-bis(acetyloxy)-2-(1-piperidinyl)androstan-16-yl)-1-methyl-, Bromide|VECURONIUM BROMIDE
C47783	Vitamin_B5	B_Vitamin	Vitamin B5|Calcium Pantothenate|D-Pantothenic Acid|PANTOTHENIC ACID|beta-Alanine, N-(2,4-dihydroxy-3,3-dimethyl-1-oxobutyl)-,(R)-(9CI)
C47784	Xenon-133	Radioisotope	Xenon-133|XENON, XE-133|Xeneisol|Xenon X-133|Xenon, Isotope of Mass 133
C47785	Zafirlukast	Anti-asthmatic_Agent	Zafirlukast|Accolate|Carbamic Acid,(3-((2-methoxy-4-((((2-methylphenyl)sulfonyl)amino)carbonyl)phenyl)methyl)-1-methyl-1H-indol-5-yl)-, Cyclopentyl Ester|Cyclopentyl 3-(2-methoxy-4-((o-tolylsulfonyl)carbamoyl)benzyl)-1-methylindole-5-carbamate|ZAFIRLUKAST
C47786	Zanamivir	Miscellaneous_Antiviral_Agent	Zanamivir|4-Guanidino-2,4-dideoxy-2,3-dehydro-N-acetylneuraminic Acid|5-Acetamido-2,6-anhydro-3,4,5-trideoxy-4-guanidino-D-glycero-D-galacto-non-2-enonic Acid|GANA|GG 167|Relenza|ZANAMIVIR
C47787	Zinc_Acetate	Nutritional_Supplement	Zinc Acetate|Acetic Acid, Zinc Salt, Dihydrate|CCRIS 3346|Galzin|ZINC ACETATE
C47788	Ziprasidone	Antipsychotic_Agent	Ziprasidone|2H-Indol-2-one, 5-(2-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-|Zeldox
C47789	Zolmitriptan	Serotonin_Agonist	Zolmitriptan|2-Oxazolidinone, 4-((3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)methyl)-,(S)-|311C90|ZOLMITRIPTAN|Zomig
C47790	Zonisamide	Anticonvulsant_Agent	Zonisamide|1,2-Benzisoxazole-3-methanesulfonamide|Excegram|ZONISAMIDE|Zonegran
C47791	_2-Hydroxyethyl_Methacrylate	Biomaterials	2-Hydroxyethyl Methacrylate|2-(Methacryloyloxy)ethanol|2-HEMA|2-HYDROXYETHYL METHACRYLATE|2-Propenoic Acid, 2-methyl-|Ethylene Glycol Methacrylate|Ethylene Glycol Monomethacrylate|Glycol Monomethacrylate|Methacrylic Acid, 2-hydroxyethyl Ester|beta-Hydroxyethyl Methacrylate
C47792	Acetylcholinesterase_Inhibitor	Enzyme_Inhibitor	Acetylcholinesterase Inhibitor
C47793	Antiarrhythmic_Agent	Adjuvant	Antiarrhythmic Agent
C47794	Serotonin_Agonist	Adjuvant	Serotonin Agonist
C47795	CNS_Stimulant	Adjuvant	CNS Stimulant
C47796	Cholinergic_Agonist	Adjuvant	Cholinergic Agonist
C47797	Ordinal_Scale	Scale	Ordinal Scale|Ordinal Sequence|Ordinal Series	A scale that uses ordered numbers where the difference between successive designations may not be constant.
C47798	Nominal_Scale	Scale	Nominal Scale	A scale that uses only categories, with no inherent order. (www.reference-wordsmith.com)
C47799	Interval_Scale	Scale	Interval Scale|Interval Sequence|Interval Series	A scale that uses ordered numbers with a constant difference but with no natural zero and where difference makes sense but ratios do not.
C47800	Ratio_Scale	Scale	Ratio Scale|Ratio Sequence|Ratio Series	A scale that uses ordered numbers with a constant difference and which has a natural zero.
C47801	Non-Negative_Integer	Integer	Non-Negative Integer|Non-Negative Integer Value	An integer with a value greater than zero.
C47802	Neoplastic_C-Cell	Neoplastic_Neuroendocrine_Cell	Neoplastic C-Cell|Neoplastic Parafollicular Cell
C47803	Isoform	Miscellaneous_Molecular_Biology_Terms	Isozyme|Isoform	The term isoform refers to variants of the same protein which can be separated on special conducting media using electrophoresis. The differences may arise from genetically determined differences in primary structure or by modification of the same primary sequence.
C47804	Serum_Calcitonin_Level_Increased	Abnormal_Blood_and_Hematology_Test_Result	Serum Calcitonin Level Increased
C47805	Malignant_Neuroendocrine_Round_Cell	Malignant_Neuroendocrine_Cell	Malignant Neuroendocrine Round Cell
C47806	Thyroglobulin_Positive_Neoplastic_Cells_Present	Positive_Immunophenotypic_Test_Result	Thyroglobulin Positive Neoplastic Cells Present
C47807	Calcitonin_Positive_Neoplastic_Cells_Present	Positive_Immunophenotypic_Test_Result	Calcitonin Positive Neoplastic Cells Present
C47808	Malignant_Squamoid_Cell	Malignant_Epithelial_Cell	Malignant Squamoid Cell
C47809	Thyroid_Gland_Epithelial_Tissue	Epithelial_Tissue|Thyroid_Gland_Tissue	Thyroid Gland Epithelial Tissue
C47811	Malignant_Cuboidal_Mucous_Cell	Mucin-Producing_Neoplastic_Epithelial_Cell	Malignant Cuboidal Mucous Cell
C47812	Malignant_Goblet-Like_Mucous_Cell	Mucin-Producing_Neoplastic_Epithelial_Cell	Malignant Goblet-Like Mucous Cell
C47813	Hoarseness	Symptom	Hoarseness
C47814	Vocal_Cord_Paralysis	Motor_Manifestations	Vocal Cord Paralysis
C47815	Neoplastic_Osteoclast-Like_Giant_Cell	Neoplastic_Multinucleated_Giant_Cell|Osteoclast-Like_Giant_Cell	Neoplastic Osteoclast-Like Giant Cell
C47816	Non-Neoplastic_Osteoclast-Like_Giant_Cell	Osteoclast-Like_Giant_Cell	Non-Neoplastic Osteoclast-Like Giant Cell
C47817	Follicular_Cell_Differentiation	Epithelial_Differentiation	Follicular Cell Differentiation
C47818	Follicular_Structures_Present	Morphologic_Finding	Follicular Structures Present
C47819	Macrofollicular_Structures_Present	Follicular_Structures_Present	Macrofollicular Structures Present
C47820	Microfollicular_Structures_Present	Follicular_Structures_Present	Microfollicular Structures Present
C47821	Malignant_Thyroid_Gland_Follicular_Clear_Cell	Adenocarcinoma_Clear_Cell|Malignant_Thyroid_Follicular_Cell|Neoplastic_Thyroid_Gland_Follicular_Clear_Cell	Malignant Thyroid Gland Follicular Clear Cell
C47822	Vmax	Physical_Phenomena_or_Properties	Vmax|Maximum Enzyme Velocity	Vmax is a parameter that defines the kinetic behavior of an enzyme.  It represents the maximum initial velocity of an enzyme catalyzed reaction at saturating substrate levels.
C47823	Km	Physical_Phenomena_or_Properties	Km	Km is a parameter that defines the kinetic behavior of an enzyme.  It represents the concentration of substrate that permits half maximal rate of reaction.
C47824	Data_Set	Information_Resources	Data Set|Dataset	A collection of related data records.
C47825	Scope	Conceptual_Entities	Scope	An area in which something acts or operates or has power or control.
C47826	Diffuse_Lesion	Lesion	Diffuse Lesion
C47827	Nuclear_Pseudoinclusion	Nuclear_Inclusion	Nuclear Pseudoinclusion
C47828	Nuclear_Clearing	Morphologic_Finding	Nuclear Clearing
C47829	Nuclear_Grooves	Morphologic_Finding	Nuclear Grooves
C47830	Pseudostratified_Columnar_Tumor_Cells_Present	Morphologic_Finding	Pseudostratified Columnar Tumor Cells Present
C47831	Neoplastic_Thyroid_Gland_Follicular_Signet_Ring_Cell	Neoplastic_Thyroid_Follicular_Cell|Signet_Ring_Cell	Neoplastic Thyroid Gland Follicular Signet Ring Cell
C47832	Neoplastic_Thyroid_Gland_Follicular_Clear_Cell	Neoplastic_Endocrine_Clear_Cell|Neoplastic_Thyroid_Follicular_Cell	Neoplastic Thyroid Gland Follicular Clear Cell
C47833	Neoplastic_Thyroid_Gland_Follicular_Cell_with_Large_and_Hyperchromatic_Nucleus	Neoplastic_Thyroid_Follicular_Cell	Neoplastic Thyroid Gland Follicular Cell with Large and Hyperchromatic Nucleus
C47834	Malignant_Endothelial_Cell	Malignant_Connective_and_Soft_Tissue_Cell|Neoplastic_Endothelial_Cell	Malignant Endothelial Cell
C47835	Nesting_Zellballen_Growth_Pattern	Nested_Proliferation	Nesting (Zellballen) Growth Pattern|Alveolar (Zellballen) Growth Pattern
C47836	American_Diabetes_Association	Professional_Organization_or_Group	American Diabetes Association|ADA	A nonprofit health organization providing diabetes research, information and advocacy. The mission of the Association is to prevent and cure diabetes and to improve the lives of all people affected by diabetes.  To fulfill this mission, the American Diabetes Association funds research, publishes scientific findings, provides information and other services to people with diabetes, their families, health professionals and the public. The Association is also actively involved in advocating for scientific research and for the rights of people with diabetes.
C47837	Male-to-Female_Transsexual_Phenotype	General_Modifier	Male-to-Female Transsexual Phenotype|Male-to-Female Transsexual	An individual who was male at birth based on physical characteristics and has undergone hormonal therapy and/or surgical procedures in order to develop more female physical characteristics.
C47838	Female-to-Male_Transsexual_Phenotype	General_Modifier	Female-to-Male Transsexual Phenotype|Female-to-Male Transsexual	An individual who was female at birth based on physical characteristics and has undergone hormonal therapy and/or surgical procedures in order to develop more male physical characteristics.
C47839	Scalar_Value	Data_Type	Scalar|Scalar Value	Any data type that stores a single value (e.g. a number or Boolean), as opposed to an aggregate data type that has many elements. (from Free On-Line Dictionary of Computing)
C47840	Null_Value	Data_Type	Null|Null Value	A special value that may be stored in some database columns to represent an unknown, missing, not applicable, or undefined value. (from Free On-Line Dictionary of Computing)
C47841	Life_Sciences_Identifier	Identifier	Life Sciences Identifier|LSID	The Life Sciences Identifier (LSID) is an I3C and OMG Life Sciences Research (LSR) Uniform Resource Name (URN) specification. The LSID concept introduces a straightforward approach to naming and identifying data resources stored in multiple, distributed data stores in a manner that overcomes the limitations of naming schemes in use today. By defining a simple, common way to identify and access biologically significant data, whether that data is stored in files, relational databases, in applications, or in internal or public data sources, LSID provides a naming standard underpinning for wide-area science and interoperability. (from W3C)
C47842	Statistical_Markup_Language	Extensible_Markup_Language	Statistical Markup Language|StatML	Statistical markup language (StatML) is an xml specifically designed for exchange of statistical data.
C47843	Forced_Expiratory_Volume_6_Test	Pulmonary_Function_Test	Forced Expiratory Volume in 6 Seconds|FEV6|Forced Expiratory Volume 6|Forced Expiratory Volume 6 Test	A test of lung function, the FEV6 is the volume exhaled during six seconds of a forced expiratory maneuver started from the level of total lung capacity.
C47844	Genomic_Molecule_Entity	Miscellaneous_Molecular_Biology_Terms	Genomic Molecule Entity|Genomic Entity|Genomic Molecule	Genomic molecules or entities are the sequences, mRNA transcripts, protein products, or other classes of entities that occur throughout the genome and the cell.
C47845	FASTA_Format	Format	FASTA Format	A sequence in FASTA format consists of a single-line description, followed by lines of sequence data. The first character of the description line is a greater-than (">") symbol in the first column.  Sequences are represented in the standard IUB/IUPAC single letter amino acid and nucleic acid codes, with a single hyphen or dash being used to represent a gap of indeterminate length; in amino acid sequences asterix ("*") can represent a translation stop.
C47846	Knowledge_Base	Database	Knowledge Base	A database or other collection of knowledge expressed in a formal knowledge representation language.
C47847	Breast_Carcinoma_with_Chondroid_Metaplasia	Mixed_Epithelial_Mesenchymal_Metaplastic_Breast_Carcinoma	Breast Carcinoma with Chondroid Metaplasia|Breast Carcinoma with Cartilaginous Metaplasia
C47848	Breast_Carcinoma_with_Osseous_Metaplasia	Mixed_Epithelial_Mesenchymal_Metaplastic_Breast_Carcinoma	Breast Carcinoma with Osseous Metaplasia
C47849	Venous_Invasion	Angioinvasion	Venous Invasion
C47850	Lymphatic_Invasion	Angioinvasion	Lymphatic Invasion
C47851	UniProt_KB	Knowledge_Base	UniProtKB|UniProt Knowledgebase	The UniProt Knowledgebase (UniProtKB), a product of the UniProt consortium, provides a central database of protein sequences with accurate, consistent, rich sequence and functional annotation.  The UniProt Knowledgebase consists of two sections: Swiss-Prot - a section containing manually-annotated records with information extracted from literature and curator-evaluated computational analysis, and TrEMBL - a section with computationally analyzed records that await full manual annotation.
C47852	Scanning_Procedure_or_Technique	Procedure	Scanning Procedure or Technique|Scan	A scan is the technique of obtaining data, or image, with a sensing device.
C47853	Sequence_Feature	Sequence	Sequence Feature	A sequence feature is an identifiable region or site of interest in a sequence.
C47854	Sentinel_Lymph_Node_Biopsy_with_Axillary_Lymph_Node_Dissection	Axillary_Lymph_Node_Dissection	Sentinel Lymph Node Biopsy with Axillary Lymph Node Dissection
C47855	Left_Breast	Breast	Left Breast
C47856	Right_Breast	Breast	Right Breast
C47857	Paget_s_Disease_of_the_Breast	Breast_Adenocarcinoma|Paget_s_Cell_Neoplasm	Paget's Disease of the Breast|Mammary Paget's Disease|Paget's Disease of Breast
C47858	Paget_s_Disease_of_the_Breast_without_Invasive_Carcinoma	Paget_s_Disease_of_the_Breast	Paget's Disease of the Breast without Invasive Carcinoma
C47860	Microcalcification_Present_in_Non-Neoplastic_Tissue	Microcalcification	Microcalcification Present in Non-Neoplastic Tissue
C47861	Microcalcification_Present_in_Neoplastic_and_Non-Neoplastic_Tissue	Microcalcification	Microcalcification Present in Neoplastic and Non-Neoplastic Tissue
C47862	Unifocal	General_Modifier	Unifocal
C47863	Extensive	General_Modifier	Extensive
C47864	Mitotic_Count	General_Modifier	Mitotic Count
C47865	Phase_V_Trial	Clinical_Trial	Phase V Trial|5|Trial Phase 5	Postmarketing surveillance is sometimes referred to as Phase V.
C47866	Three_Dimensional_Size	Size	Three Dimensional Size
C47867	Synoptic_Surgical_Pathology_Report	Surgical_Pathology_Report	Synoptic Surgical Pathology Report	A pathology report based upon samples obtained by or during surgery.
C47868	Blood_Chemistry_Study	Test|Test_Generic	Blood Chemistry Study|blood cell count	A procedure in which a sample of blood is examined to measure the amounts of certain substances made in the body. An abnormal amount of a substance can be a sign of disease in the organ or tissue that produces it.
C47871	Metropolitan_France	Geographic_Area	Metropolitan France	The part of France situated in Western Europe, including Corsica, as opposed to the overseas departments and territories of the French Republic. Metropolitan France extends from the Mediterranean Sea to the North Sea and from the Rhine River to the Atlantic Ocean.
C47872	QS_Wave	Electrocardiographic_Finding	QS Wave|Abnormal Q Wave	A QS wave is an abnormal Q wave, and is an electrocardiographic finding.  'QS" wave or abnormal 'Q' wave in the right precordial leads, epicardial leads of the right ventricle and unipolar aVR lead with a high and relatively broad 'R' wave simulating an incomplete left bundle branch block without 'Q' waves in leads 1, aVL and left precordial leads - reciprocal and antagonistic aspects. (www.infarctcombat.org/abs.ghm-8.html)
C47874	Separation_Column	Diagnostic_Therapeutic_and_Research_Equipment	Separation Column|Column	A tube used in column chromatography.
C47875	Mass_Spectrometer	Diagnostic_Therapeutic_and_Research_Equipment	Mass Spectrometer	An instrument that determines the exact mass of charged particles or ions by measuring the flight path through a set of magnetic and electric fields.
C47876	Resolution_Property	Conceptual_Entities	Resolution|Resolution Property	The size of the smallest element that can be separated from neighboring elements. (from scienceworld.wolfram.com)
C47877	Cutoff	Conceptual_Entities	Cutoff	A designated limit beyond which something cannot function or must be terminated.
C47879	Base_64	Format	Base 64	A file format using 64 ASCII characters to encode the six bit binary data values 0-63. Base 64 is used when transmitting binary data through text-only media such as electronic mail.
C47880	Simple	General_Modifier	Simple	Easy, not involved or complicated, not elaborate, having few parts.
C47881	Complex	General_Modifier	Complex	Hard, involved or complicated, elaborate, having many parts.
C47882	Increment	Conceptual_Entities	Increment|Step	The amount by which something increases.
C47883	XPath	Language	XML Path Language|XPath	XPath is a language that describes a way to locate and process items in Extensible Markup Language (XML) documents by using an addressing syntax based on a path through the document's logical structure or hierarchy. (from Computer, Telephony & Electronics Industry Glossary)
C47884	Web_Service_Definition_Language	Extensible_Markup_Language	Web Service Definition Language|WSDL	WSDL is an XML format for describing network services as a set of endpoints operating on messages containing either document-oriented or procedure-oriented information. (Free On-Line Dictionary of Computing)
C47885	Project	Clinical_or_Research_Activity	Project	Any piece of work that is undertaken or attempted.
C47886	Repeat	Clinical_or_Research_Activity	Repeat|Replicate	Make or do or perform again.
C47887	Packing_Dosage_Form	Solid_Dosage_Form	Packing Dosage Form|PACKING|Packing Dose Form	A material, usually covered by or impregnated with a drug, that is inserted into a body cavity or between the tooth enamel and the gingival margin.
C47888	Contract	Document_Type	Contract	A binding agreement between two or more persons that is enforceable by law.
C47889	Suture_Dosage_Form	Solid_Dosage_Form	Suture Dosage Form|SUTURE|Suture Dose Form	A strand or fiber used to hold wound edges in apposition during healing.
C47890	Diaphragm_Dosage_Form	Solid_Dosage_Form	Diaphragm Dosage Form|DIAPHRAGM|DIAPHRAM|Diaphragm Dose Form|Vaginal Diaphragm Dosage Form	A device usually dome-shaped, worn during copulation over the cervical mouth for prevention of conception or infection.
C47891	Test_Generic	Techniques	Test|TST	A procedure for critical evaluation; a means of determining the presence, quality, or truth of something.
C47892	Tampon_Dosage_Form	Solid_Dosage_Form	Tampon Dosage Form|TAMPON|Tampon Dose Form	A plug made of cotton, sponge, or oakum variously used in surgery to plug the nose, vagina, etc., for the control of hemorrhage or the absorption of secretions.
C47893	Routine	Clinical_or_Research_Activity	Routine	An unvarying or habitual method or procedure.
C47894	Set	Conceptual_Entities	Set	A group of things of the same kind that belong together and are so used.
C47895	Benchmark	Conceptual_Entities	Benchmark	A standard by which something can be measured or judged.
C47896	Warning	Conceptual_Entities	Warning|Caveat	Cautionary advice about something.
C47897	Tape_Dosage_Form	Solid_Dosage_Form	Tape Dosage Form|TAPE|Tape Dose Form	A narrow woven fabric, or a narrow extruded synthetic (such as plastic), usually with an adhesive on one or both sides.
C47898	Swab_Dosage_Form	Solid_Dosage_Form	Swab Dosage Form|SWAB|Swab Dose Form	A wad of absorbent material usually wound around one end of a small stick and used for applying medication or for removing material from an area.
C47899	Implementation	Clinical_or_Research_Activity	Implementation	The act of carrying into effect.
C47900	Pseudocode	Document_Type	Pseudocode|Pseudo-code	An outline of a computer program written in plain language.
C47901	Source_Code	Code	Source Code	Program instructions written as an ASCII text file; must be translated by a compiler or interpreter or assembler into the object code for a particular computer before execution.
C47902	Article	Document_Type	Article	Nonfictional prose forming an independent part of a publication.
C47903	Programming_Language	Language	Programming Language|Language	A formal language in which computer programs are written. The definition of a particular language consists of both syntax (how the various symbols of the language may be combined) and semantics (the meaning of the language constructs). (Free On-LIne Dictionary of Computing)
C47904	Build	Conceptual_Entities	Build|Pre-Release Version	In a programming context, a build is a version of a program. As a rule, a build is a pre-release version and as such is identified by a build number, rather than by a release number. (from whatis.com)
C47905	Input	Conceptual_Entities	Input	Anything added into a sytem.
C47906	Output	Conceptual_Entities	Output	Anything coming out of a system.
C47907	Compiler	Computer_Program	Compiler	A program that decodes instructions written in a higher order language and produces an assembly language program.
C47908	Operating_System	Computer_Program	Operating System	The low-level software which handles the interface to peripheral hardware, schedules tasks, allocates storage, and presents a default interface to the user when no application program is running. (Free On-Line Dictionary of Computing)
C47909	Postcondition	Logical_Condition	Postcondition|Post-condition	A fact that must always be true just after the execution of some section of code.
C47910	Precondition	Logical_Condition	Precondition|Pre-condition	A fact that must always be true just prior to the execution of some section of code.
C47911	Run	Clinical_or_Research_Activity	Run	The act of testing or performing something.
C47912	Sponge_Dosage_Form	Solid_Dosage_Form	Sponge Dosage Form|SPONGE|Sponge Dose Form	An absorbent pad of folded gauze or cotton.
C47913	Poultice_Dosage_Form	Solid_Dosage_Form	Poultice Dosage Form|POULTICE|Poultice Dose Form	A soft, moist mass of meal, herbs, seed, etc., usually applied hot in cloth that consists of gruel-like consistency.
C47914	Strip_Dosage_Form	Solid_Dosage_Form	Strip Dosage Form|STRIP|Strip Dose Form	A long narrow piece of material.
C47915	Intrauterine_Device_Dosage_Form	Solid_Dosage_Form	Intrauterine Device Dosage Form|INTRAUTERINE DEVICE|IUD|Intrauterine Device Dose Form	A device inserted and left in the uterus to prevent effective conception.
C47916	Kit_Dosage_Form	Pharmaceutical_Dosage_Form	Kit Dosage Form|KIT|Kit Dose Form	A packaged collection of related material.
C47917	Male-to-Female_Transsexual_Animal	Laboratory_Animal	Male-to-Female Transsexual Animal|Male-to-Female Transsexual	An organism that was male at birth based on physical characteristics and has undergone hormonal therapy and/or surgical procedures in order to develop more female physical characteristics.
C47918	Female-to-Male_Transsexual_Animal	Laboratory_Animal	Female-to-Male Transsexual Animal|Female-to-Male Transsexual	An organism that was female at birth based on physical characteristics and has undergone hormonal therapy and/or surgical procedures in order to develop more male physical characteristics.
C47919	Hyperlink	List	Hyperlink|Link	A reference (link) from some point in one hypertext document to another document, another place in the same document, or a website. (from Free On-Line Dictionary of Computing)
C47920	Service	Clinical_or_Research_Activity	Service	Work, or a product of that work, done by one person or group that benefits another.
C47921	Name-Value_Pair	UML_Entity	Name-Value Pair|Name Value|Name Value Pair|Name-Value|Name/Value|Name/Value Pair	The name of a field together with the value of the field.
C47922	Pathname	Document_Type	Pathname|File Path|Path	The specification of a node (file or directory) in a hierarchical file system, usually specified by listing the nodes top-down.
C47923	Offset	Characteristics	Offset	The distance between a point and a fixed reference point; difference between a set point and the actual reading.
C47924	Mass_Spectrometry_Markup_Language	Extensible_Markup_Language	Mass Spectrometry Markup Language|MzXML	An XML based common file format for mass spectrometry data.
C47925	Data_Processing	Computer_Sciences	Data Processing	A series of operations on data by a computer in order to retrieve or transform or classify information.
C47926	Mass_Analyzer	Diagnostic_Therapeutic_and_Research_Equipment	Mass Analyzer	A device that separates a mixture of ions by their mass-to-charge ratios.
C47927	Ionization_Source	Diagnostic_Therapeutic_and_Research_Equipment	Ionization Source	A device that converts a sample into an ion stream.
C47929	Deconvolution	Data_Processing	Deconvolution	Processing of signal parameters to exclude undesirable effects, including those caused by the detection instrument itself.
C47930	Centroid	General_Modifier	Centroid	A point that is the center of mass of an object of uniform density or the geometric center of a planar object.
C47933	Isotope	Inorganic_Chemical	Isotope	Substances having the same number of protons in their nuclei and hence having the same atomic number, but differing in the number of neutrons and therefore, in the mass number. (from On-line Medical Dictionary)
C47934	Phosphorus	Element_or_Isotope	Phosphorus	An element with atomic symbol P, atomic number 15, and atomic weight 30.97.
C47935	Active_Site	Protein_Structure	Active Site	The catalytic site of an enzyme, the part of an enzyme where the actual enzymatic function is performed.
C47936	Cross_Link	Macromolecular_Structure	Cross Link	Any covalent linkage between two polymers or between two different regions of the same polymer.
C47937	Helix_Structure	Macromolecular_Structure	Helix	A structure consisting of something wound in a continuous series of loops.
C47938	Initiation	Conceptual_Entities	Initiation	The act of starting something; an act that sets in motion some course of events.
C47939	Consecutive	General_Modifier	Consecutive	In regular succession without gaps.
C47940	Terminal	General_Modifier	Terminal	Being or situated at an end; occurring at or forming an end.
C47941	Proprotein	Miscellaneous_Molecular_Biology_Terms	Proprotein|Propeptide	An inactive protein precursor that is made active by cleavage or glycosylation.
C47942	Repeat_Pattern	Pattern	Repeat|Repeat Pattern	Two or more adjacent copies of an identical pattern.
C47943	Transit_Peptide	Protein_Sequence	Transit Peptide|Transit Domain|Transit Peptide Domain|Transit Sequence	The N-terminal sequence of a protein that is required to direct the localization of a cytoplasmic protein to a subcellular membrane-bound organelle.
C47944	Uncertain	General_Modifier	Uncertain|Unsure	Not established beyond doubt; still undecided or unknown.
C47945	Beta_Strand	Secondary_Protein_Structure	Beta Sheet|B-strand|Beta Strand	A beta strand is an extended polypeptide chain with the sidechains pointing away from the backbone and oriented on opposite sides of the backbone from one residue to another.
C47946	Protein_Turn	Secondary_Protein_Structure	Protein Turn|Turn	A protein secondary structure in which the polypeptide bends back on itself and is stabilized by hydrogen bonds.
C47947	Patch	Drug_Delivery_System	Patch
C47948	Amrubicin_Hydrochloride	Anthracycline_Antibiotic	Amrubicin Hydrochloride|Calsed|SM-5887|SMP-5887	A novel, totally synthesized, 9-amino-anthracycline anticancer agent. Amrubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication, and consequently RNA and protein synthesis. This causes cell growth inhibition and eventually cell death. (NCI05)
C47949	Vacuum-Assisted_Biopsy	Image_Guided_Biopsy|Needle_Biopsy	Vacuum-Assisted Biopsy|Mammotome	A minimally invasive biopsy system that uses either sterotactic mammography or ultrasound for precise positioning of a vacuum-assisted biopsy probe.
C47950	Mammotome_Clip	Medical_Device	Mammotome Clip	A biocompatible stainless steel tag placed at the site of a breast tissue sample.  It appears on a mammogram to help pinpoint an area of past concern.
C47951	Routine_Signature	Conceptual_Entities	Routine Signature|Signature	The types or domains, and order, in some representations, of inputs to and outputs from a function. (NIST)
C47952	Routine_Contract	Logical_Condition	Routine Contract|Contract	A logical constraint that can be a pre-condition, post-condition or logical invariant that holds throughout the lifetime of the function or object.
C47953	Logical_Condition	Properties_or_Attributes	Logical Condition|Condition	An assumption on which rests the validity or effect of something else.
C47954	Communication_Contact	Conceptual_Entities	Communication Contact|Contact	A channel for communication between groups.
C47955	Means	Conceptual_Entities	Means|Method|Prodecure|Technique	A way of doing something; how a result is obtained or an end is achieved.
C47956	Acyclovir_Sodium	Nucleic_Acid_Synthesis_Inhibitor	Acyclovir Sodium|ACYCLOVIR SODIUM
C47957	Albuterol_Sulfate	Bronchodilator	Albuterol Sulfate|ALBUTEROL SULFATE|Proventil|Ventolin
C47958	Aminosalicylate_Sodium	Antitubercular_Agent	Aminosalicylate Sodium|AMINOSALICYLATE SODIUM|Pamisyl Sodium
C47959	Ampicillin_Sodium	Penicillin_Antibiotic	Ampicillin Sodium|AMPICILLIN SODIUM|D-(-)-6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, Sodium Salt
C47960	Ampicillin_Trihydrate	Penicillin_Antibiotic	Ampicillin Trihydrate|AMPICILLIN TRIHYDRATE
C47961	Azathioprine_Sodium	Immunosuppressant|Inosine_5-Phosphate_Dehydrogenase_Inhibitor|Purine_Antagonist	Azathioprine Sodium|AZATHIOPRINE SODIUM|Imuran|Imurel
C47962	Betamethasone_Valerate	Therapeutic_Glucocorticoid	Betamethasone Valerate|BETAMETHASONE VALERATE
C47963	Betamethasone_Dipropionate	Therapeutic_Glucocorticoid	Betamethasone Dipropionate|BETAMETHASONE DIPROPIONATE|Diprolene
C47964	Betamethasone_Sodium_Phosphate	Therapeutic_Glucocorticoid	Betamethasone Sodium Phosphate|BETAMETHASONE SODIUM PHOSPHATE
C47965	Cefadroxil_Hemihydrate	Cephalosporin_Antibiotic	Cefadroxil Hemihydrate|CEFADROXIL HEMIHYDRATE
C47966	Cefamandole_Nafate	Cephalosporin_Antibiotic	Cefamandole Nafate|CEFAMANDOLE NAFATE|Mandol
C47967	Cefamandole_Sodium	Cephalosporin_Antibiotic	Cefamandole Sodium|CEFAMANDOLE SODIUM|D-7-Mandelamido-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, Monosodium Salt
C47968	Cefazolin_Sodium	Cephalosporin_Antibiotic	Cefazolin Sodium|(6R-trans)-3-(((5-methyl-1,3,4-thiadiazol-2-yl)thio)methyl)-8-oxo-7-(((1H-tetrazol-1-yl)acetyl)amino)-5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, Sodium Salt|Ancef|CEFAZOLIN SODIUM|Kefzol|SKF 41558
C47969	Cephalexin_Hydrochloride	Cephalosporin_Antibiotic	Cephalexin Hydrochloride|CEPHALEXIN HYDROCHLORIDE|Keftab
C47970	Cephradine_Dihydrate	Cephalosporin_Antibiotic	Cephradine Dihydrate|CEPHRADINE DIHYDRATE
C47971	Cephradine_Monohydrate	Cephalosporin_Antibiotic	Cephradine Monohydrate|CEPHRADINE MONOHYDRATE|Forticef
C47972	Chloramphenicol_Sodium_Succinate	Antibiotic|Protein_Synthesis_Inhibitor	Chloramphenicol Sodium Succinate|CHLORAMPHENICOL SODIUM SUCCINATE
C47973	Chlordiazepoxide_Hydrochloride	Benzodiazepine	Chlordiazepoxide Hydrochloride|CHLORDIAZEPOXIDE HYDROCHLORIDE|Libritaps|Librium
C47974	Chlorhexidine_Gluconate	Miscellaneous_Antibiotic	Chlorhexidine Gluconate|CHLORHEXIDINE GLUCONATE
C47975	Chlorpromazine_Hydrochloride	Multidrug_Resistance_Modulator|Phenothiazine	Chlorpromazine Hydrochloride|2-Chloro-10-(3-(dimethylamino)propyl)phenothiazine Monohydrochloride|CHLORPROMAZINE HYDROCHLORIDE
C47976	Ciprofloxacin_Hydrochloride	Antitubercular_Agent|Quinolone_Antibiotic|Topoisomerase-II_Inhibitor	Ciprofloxacin Hydrochloride|1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic Acid, Monohydrochloride, Monohydrate|CIPROFLOXACIN HYDROCHLORIDE|Ciloxan
C47977	Clindamycin_Hydrochloride	Miscellaneous_Antibiotic|Protein_Synthesis_Inhibitor	Clindamycin Hydrochloride|7-Chloro-7-deoxylincomycin Hydrochloride|CLINDAMYCIN HYDROCHLORIDE
C47978	Clindamycin_Phosphate	Miscellaneous_Antibiotic|Protein_Synthesis_Inhibitor	Clindamycin Phosphate|7(S)-Chloro-7-deoxylincomycin 2-phosphate|CLINDAMYCIN PHOSPHATE|U 28508
C47979	Clonidine_Hydrochloride	Adjuvant_Analgesic	Clonidine Hydrochloride|CLONIDINE HYDROCHLORIDE|Catapres
C47980	Demeclocycline	Tetracycline_Antibiotic	Demeclocycline|7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide|DEMECLOCYCLINE
C47981	Diatrizoate_Sodium	Contrast_Agent	Diatrizoate Sodium|3,5-Diacetamido-2,4,6-triiodobenzoic Acid, Sodium Salt|DIATRIZOATE SODIUM|Urografic Acid Sodium Salt	An iodinated radiopaque X-ray contrast medium. Diatrizoate sodium blocks X-rays, thereby allowing body structures containing iodine to be delineated in contrast to those structures that do not contain iodine and allowing visualization of these areas. This contrast agent is used as a diagnostic aid in angiography, urography and radiography. (NCI05)
C47982	Diatrizoate_Meglumine	Contrast_Agent	Diatrizoate Meglumine|1-Deoxy-1-(methylamino)-D-glucitol 3,5-diacetamido-2,4,6-triiodobenzoate (salt)|DIATRIZOATE MEGLUMINE
C47983	Diclofenac_Potassium	Cyclooxygenase_Inhibitor	Diclofenac Potassium|2-((2,6-Dichlorophenyl)amino)-benzeneacetic Acid, Monopotassium Salt|CGP 45840B|Cataflam|DICLOFENAC POTASSIUM
C47984	Diclofenac_Sodium	Cyclooxygenase_Inhibitor	Diclofenac Sodium|2-[(2,6-Dichlorophenyl)amino]benzeneacetic Acid Monosodium Salt|DICLOFENAC SODIUM|GP 45840|Voltaren
C47985	Dicloxacillin_Sodium	Penicillin_Antibiotic	Dicloxacillin Sodium|3-(2,6-Dichlorophenyl)-5-methyl-4-isoxazolyl Penicillin Sodium Monohydrate|DICLOXACILLIN SODIUM
C47986	Erythromycin_Estolate	Macrolide_Antibiotic	Erythromycin Estolate|ERYTHROMYCIN ESTOLATE
C47987	Erythromycin_Ethylsuccinate	Macrolide_Antibiotic	Erythromycin Ethylsuccinate|ERYTHROMYCIN ETHYLSUCCINATE|Pediamycin
C47988	Erythromycin_Lactobionate	Macrolide_Antibiotic	Erythromycin Lactobionate|ERYTHROMYCIN LACTOBIONATE
C47989	Erythromycin_Stearate	Macrolide_Antibiotic	Erythromycin Stearate|ERYTHROMYCIN STEARATE|Erythrocin Stearate
C47990	Estradiol_Acetate	Estrogen	Estradiol Acetate|17Beta-hydroxyestra-1,3,5(10)-trien-3-yl Acetate|ESTRADIOL ACETATE
C47991	Estradiol_Cypionate	Estrogen	Estradiol Cypionate|17beta-Estradiol 17-Cyclopentylpropionate|ESTRADIOL CYPIONATE
C47992	Estradiol_Hemihydrate	Estrogen	Estradiol Hemihydrate|ESTRADIOL HEMIHYDRATE
C47993	Ethacrynate_Sodium	Glutathione_Transferase_Inhibitor|Multidrug_Resistance_Modulator	Ethacrynate Sodium|ETHACRYNATE SODIUM|Edecrin Sodium|Sodium Edecrin|Sodium Ethacrynate
C47994	Fentanyl_Citrate	Opioid	Fentanyl Citrate|Actiq|FENTANYL CITRATE|Fentyl|Oralet|Sublimaze
C47995	Fluphenazine_Hydrochloride	Antipsychotic_Agent	Fluphenazine Hydrochloride|FLUPHENAZINE HYDROCHLORIDE|Permitil|Prolixin
C47996	Fluphenazine_Decanoate	Antipsychotic_Agent	Fluphenazine Decanoate|FLUPHENAZINE DECANOATE|Flufenazine Decanoate
C47997	Flurbiprofen_Sodium	Carbonic_Anhydrase_Inhibitor|Cyclooxygenase_Inhibitor	Flurbiprofen Sodium|2-Fluoro-alpha-methyl-4-diphenylacetic Acid Sodium Salt|FLURBIPROFEN SODIUM
C47998	Haloperidol_Decanoate	Butyrophenone	Haloperidol Decanoate|HALOPERIDOL DECANOATE
C47999	Indomethacin_Sodium	Cyclooxygenase_Inhibitor	Indomethacin Sodium|INDOMETHACIN SODIUM|Indocin I.V.
C48000	Lidocaine_Hydrochloride	Anesthetic_Agent	Lidocaine Hydrochloride|2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide Monohydrochloride|LIDOCAINE HYDROCHLORIDE|Xylocaine|Xylocitin|Xylotox
C48001	Magnesium_Acetate_Tetrahydrate	Nutritional_Supplement	Magnesium Acetate Tetrahydrate|MAGNESIUM ACETATE TETRAHYDRATE
C48002	Melphalan_Hydrochloride	Nitrogen_Mustard_Compound	Melphalan Hydrochloride|3-(p-(bis(2-chloroethyl)amino)phenyl)-L-Alanine, Hydrochloride|Alkeran|Alkerana|MELPHALAN HYDROCHLORIDE
C48003	Methylprednisolone_Acetate	Antiemetic_Agent|Therapeutic_Glucocorticoid	Methylprednisolone Acetate|11beta,17,21-Trihydroxy-6alpha-methylpregna-1,4-diene-3,20-dione 21-Acetate|D-Med|Depo-Medrate|Depo-Medrol|Depo-Medrone|METHYLPREDNISOLONE ACETATE|Methylprednisolone acetate
C48004	Methylprednisolone_Sodium_Succinate	Antiemetic_Agent|Therapeutic_Glucocorticoid	Methylprednisolone Sodium Succinate|A-MethaPred|Asmacortone|Cryosolona|METHYLPREDNISOLONE SODIUM SUCCINATE|Medrate|Metypred|Prednilem|Solu Moderin|Solu-Medrol|Solu-Medrone
C48005	Metronidazole_Hydrochloride	Protein_Synthesis_Inhibitor|Trichomonacide_Agent	Metronidazole Hydrochloride|Flagyl I.V.|METRONIDAZOLE HYDROCHLORIDE|SC 32642
C48006	Naproxen_Sodium	Cyclooxygenase_Inhibitor	Naproxen Sodium|Anaprox|NAPROXEN SODIUM|RS 3650
C48007	Ondansetron_Hydrochloride	Antiemetic_Agent	Ondansetron Hydrochloride|GR 38032F|GR-C507/75|ONDANSETRON HYDROCHLORIDE|SN-307|Zofran
C48008	Oxaprozin_Potassium	Cyclooxygenase_Inhibitor	Oxaprozin Potassium|4,5-Diphenyl-2-oxazolepropanoic Acid, Potassium Salt|Daypro Alta|OXAPROZIN POTASSIUM
C48009	Oxycodone_Terephthalate	Opioid	Oxycodone Terephthalate|OXYCODONE TEREPHTHALATE
C48010	Oxycodone_Hydrochloride	Opioid	Oxycodone Hydrochloride|4,5alpha-Epoxy-14-hydroxy-3-methoxy-17-methylmorphinan-6-one Hydrochloride|OXYCODONE HYDROCHLORIDE|OxyContin|Roxicodone
C48011	Phenytoin_Sodium	Anticonvulsant_Agent	Phenytoin Sodium|5,5-Diphenyl-2,4-imidazolidinedione, Monosodium Salt|Dilantin|PHENYTOIN SODIUM
C48012	Prilocaine_Hydrochloride	Anesthetic_Agent	Prilocaine Hydrochloride|2-(Propylamino)-o-propionotoluidide Hydrochloride|Citanest|L-67|PRILOCAINE HYDROCHLORIDE|Xylonest
C48013	Prochlorperazine_Edisylate	Phenothiazine	Prochlorperazine Edisylate|2-Chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine Edisylate|PROCHLORPERAZINE EDISYLATE
C48014	Quinidine_Sulfate	Multidrug_Resistance_Modulator	Quinidine Sulfate|(9S)-6'-Methoxycinchonan-9-ol Sulfate (2:1) (salt)|QUINIDINE SULFATE|Quinidex
C48015	Quinidine_Gluconate	Multidrug_Resistance_Modulator	Quinidine Gluconate|9S-6'-Methoxy-cinchonan-9-ol, Mono-D-gluconate(salt)|Duraquin|QUINIDINE GLUCONATE|Quinaglute
C48016	Riboflavin_Phosphate_Sodium	B_Vitamin	Riboflavin Phosphate Sodium|RIBOFLAVIN PHOSPHATE SODIUM
C48017	Sodium_Acetate_Anhydrous	Drug_Vehicle	Sodium Acetate, Anhydrous|SODIUM ACETATE, ANHYDROUS
C48018	Sodium_Sulfate_Anhydrous	Electrolyte_Replacement_Agent	Sodium Sulfate, Anhydrous|SODIUM SULFATE, ANHYDROUS
C48019	Terbinafine	Antifungal_Agent	Terbinafine|(E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalene Methanamine|TERBINAFINE
C48020	Tetracycline_Hydrochloride	Tetracycline_Antibiotic	Tetracycline Hydrochloride|(4S,4aS,5aS,6S,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Monohydrochloride|Achromycin|TETRACYCLINE HYDROCHLORIDE|Tetracycline HCl
C48021	Epinephrine_Bitartrate	Adrenal_Agent	Epinephrine Bitartrate|EPINEPHRINE BITARTRATE
C48022	Hydrocortisone_Butyrate	Therapeutic_Glucocorticoid	Hydrocortisone Butyrate|11-beta,17-alpha,21-Trihydroxy-4-pregnene-3,20-dione 17-alpha-butyrate|HYDROCORTISONE BUTYRATE
C48023	Hydrocortisone_Probutate	Therapeutic_Glucocorticoid	Hydrocortisone Probutate|HYDROCORTISONE PROBUTATE
C48024	Hydrocortisone_Valerate	Therapeutic_Glucocorticoid	Hydrocortisone Valerate|11beta,17,21-Trihydroxypregn-4-ene-3,20-dione 17-Valerate|HYDROCORTISONE VALERATE
C48025	Thiamine_Hydrochloride	B_Vitamin	Thiamine Hydrochloride|3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-m-ethylthiazolium Chloride, Monohydrochloride|THIAMINE HYDROCHLORIDE|Thiamine HCl|Vitamin B1 Hydrochloride
C48026	Triamcinolone_Hexacetonide	Therapeutic_Glucocorticoid	Triamcinolone Hexacetonide|(11beta,16alpha)-21-(3,3-Dimethyl-1-oxobutoxy)-9-fluoro-11-hydroxy-16,17-((1-methylethylidene)bis(oxy))pregna-1,4-diene-3,20-dione|Aristospan|TRIAMCINOLONE HEXACETONIDE
C48027	Triamcinolone_Acetonide	Therapeutic_Glucocorticoid	Triamcinolone Acetonide|9-alpha-Fluoro-11-beta,21-dihydroxy-16-alpha-isopropylidenedioxy-1,4-pregnadiene,3,20-dione|Aristocort A|Kenalog|Nasacort|TRIAMCINOLONE ACETONIDE
C48028	Trimethoprim_Sulfate	Urinary_Anti-Infective_Agent	Trimethoprim Sulfate|2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine Sulfate (2:1)|TRIMETHOPRIM SULFATE
C48029	Valproate_Sodium	Anticonvulsant_Agent	Valproate Sodium|2-Propylpentanoic Acid Sodium Salt|Depacon|Ergenyl|VALPROATE SODIUM
C48030	Pyridoxine_Hydrochloride	B_Vitamin|Miscellaneous_Chemoprotective_Agent	Pyridoxine Hydrochloride|5-Hydroxy-6-methyl-3,4-pyridinedimethanol Hydrochloride|Beesix|Hexa-Betalin|PYRIDOXINE HYDROCHLORIDE|Vitamin B6 Hydrochloride
C48031	Ziprasidone_Hydrochloride	Antipsychotic_Agent	Ziprasidone Hydrochloride|5-(2-(4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl)ethyl)-6-chloro-1,3-dihydro-2H-Indol-2-one Monohydrochloride|Geodon|ZIPRASIDONE HYDROCHLORIDE
C48032	Ziprasidone_Mesylate	Antipsychotic_Agent	Ziprasidone Mesylate|Geodon|ZIPRASIDONE MESYLATE
C48033	Marriage	Social_Concepts	Marriage|Married	The state of being a married couple.
C48034	Unit_of_Linear_Acceleration	Unit_of_Acceleration	Unit of Linear Acceleration	An indication of the type of unit of measure being used to express linear acceleration.
C48036	Operator	Person	Operator	A person that operates some apparatus or machine.
C48037	Unit_of_Area	Unit_by_Category	Unit of Area|Area Unit	An indication of the type of unit of measure being used to express an area.
C48038	Integration	Data_Processing	Integration	An operation used in calculus whereby the integral of a function is determined.
C48039	Spot	Conceptual_Entities	Spot	A mark on a substance or body made by foreign matter; a blot; a place discolored. (from On-line Medical Dictionary)
C48040	Matrix-Assisted_Laser_Desorption_Ionization_Mass_Spectrometry	Mass_Spectrometry	Matrix-Assisted Laser Desorption Ionization Mass Spectrometry|MALDI|Matrix Assisted Laser Desorption Ionization Mass Spectrometry	A mass spectrometric technique that is used for the analysis of large biomolecules. Analyte molecules are embedded in an excess matrix of small organic molecules that show a high resonant absorption at the laser wavelength used. The matrix absorbs the laser energy, thus inducing a soft disintegration of the sample- matrix mixture into free (gas phase) matrix and analyte molecules and molecular ions. In general, only molecular ions of the analyte molecules are produced and almost no fragmentation occurs. This makes the method well suited for molecular weight determinations and mixture analysis. (CHI)
C48041	Plate	Diagnostic_Therapeutic_and_Research_Equipment	Plate	A sheet of metal or wood or glass or plastic.
C48042	Dead_Volume	Volume	Dead Volume	Any volume which a component introduces to a system that is not cleanly swept and relies on diffusion to clear the space; a dead-end passageway or cavity that can retain materials to contaminate subsequent samples or flow media.
C48043	Protein_Helix	Secondary_Protein_Structure	Protein Helix|Helix	A protein secondary structure motif. Amino acids are arranged in a right-handed rod like structure stabilized by hydrogen bonds between the C=O and the N-H groups of the main chain. Types include:alpha-helix, 3.10 helix and pi-helix.
C48044	Precursor	Conceptual_Entities	Precursor	A substance from which another substance is formed.
C48045	Precision	Characteristics	Precision	The quality of being reproducible in amount or performance.
C48046	Pair	General_Modifier	Pair	A set of two similar things considered as a unit.
C48047	Byte	Conceptual_Entities	Byte	A sequence of 8 bits processed as a single unit of information.
C48048	Polarity	Characteristics	Polarity	The positive or negative direction of an electrical, acoustical, or magnetic force.
C48049	Mass-to-Charge_Ratio	Physical_Phenomena_or_Properties	Mass-to-Charge Ratio|m/z|mz	The abbreviation m/z is used to denote the dimensionless quantity formed by dividing the mass number of an ion by its charge number. It has long been called the mass-to-charge ratio although m is not the ionic mass nor is z a multiple or the elementary (electronic) charge e. (from IUPAC Compendium)
C48050	Charge	Characteristics	Charge	The quantity of unbalanced electricity in a body (either positive or negative) and construed as an excess or deficiency of electrons.
C48051	Window	Conceptual_Entities	Window	An opening in the wall of a building, usually to admit light and air; an opening that resembles a window in appearance or function; a rectangular part of a computer screen that contains a display different from the rest of the screen.
C48052	Collision	Physical_Phenomena_or_Properties	Collision	An accident resulting from violent impact of a moving object; an brief event in which two or more bodies come together.
C48053	Shoot	Conceptual_Entities	Shoot	Send forth suddenly, intensely, swiftly; emit suddenly and forcefully.
C48054	Peak	Conceptual_Entities	Peak	The most extreme possible amount or value; the highest point.
C48055	Base_Qualifier	General_Modifier	Base	The most important or necessary part of something.
C48056	Base	Drugs_and_Chemicals_Functional_Classification	Base	A substance that dissociates to give hydroxide ions in aqueous solutions; a substance capable of donating a pair of electrons (to an acid) for the formation of a coordinate covalent bond; a substance whose molecule or ion can combine with a proton (hydrogen ion); a substance that combines with acids to form salts.
C48057	Acid	Drugs_and_Chemicals_Functional_Classification	Acid	A substance that yields hydrogen ions or protons in aqueous solutions; a substance capable of accepting a pair of electrons for the formation of a coordinate covalent bond; a substance whose hydrogen can be replaced by metals or basic radicals, or which react with bases to form salts and water.
C48058	Energy	Physical_Phenomena_or_Properties	Energy	The capacity of a physical system to do work.
C48059	Ionization	Physical_Phenomena_or_Properties	Ionization	Any process by which a neutral atom gains or loses electrons, thus acquiring a net charge, as the dissociation of a substance in solution into ions or ion production by the passage of radioactive particles. (On-line Medical Dictionary)
C48060	Spotting	Conceptual_Entities	Spotting	The act of creating a spot.
C48061	Collision-Induced_Dissociation	Physical_Chemical_Techniques	Collision-Induced Dissociation|CID	A method by which fragmentation can be achieved.  CID is accomplished by selecting an ion of interest with the mass analyzer and then subjecting that ion to collisions with neutral atoms or molecules.  The resulting fragment ions are then mass analyzed. (from The Expanding Role of Mass Spectrometry in Biotechnology by Gary Siuzdak)
C48149	Beta-adrenergic_Agonist	Adrenergic_Agent	Beta-Adrenergic Agonist
C48150	Float_Value	Data_Type	Float|Float Value	A number that can have its decimal point in any position.
C48151	Generation	Conceptual_Entities	Generation	The act of bringing into being.
C48152	Microgram	Unit_of_Mass|Unit_of_Potency	Microgram|MICROGRAM|UGM|mcg	A metric unit of mass equal to one millionth of a gram or one one thousandth of a milligram.
C48153	Microliter	Unit_of_Potency|Unit_of_Volume	Microliter|CU MM|CUBIC MILLIMETER|MICROLITER|UL|mcl	A metric unit of volume equal to one millionth of a liter or one one-thousandth of a milliliter.
C48154	Minute	Unit_of_Time	Minute|m|min	A unit measure of time equal to 60 seconds.
C48155	Gram	Unit_of_Mass|Unit_of_Potency	Gram|GM|GRAM|Gramme|g	A metric unit of mass equal to one one thousandth of a kilogram.
C48156	Default	General_Modifier	Default	An option that is selected automatically unless an alternative is specified.
C48157	_7q21-q22_1	Chromosome_Band	7q21-q22.1	A chromosome band present on 7q
C48158	Wavelength	Characteristics	Wavelength	The distance (measured in the direction of propagation) between two points in the same phase in consecutive cycles of a wave.
C48159	_10q23_33	Chromosome_Band	10q23.33	A chromosome band present on 10q
C48160	Freeze_Technique	Techniques	Freezing|Freeze Technique	The act or event which causes the transition from a liquid to solid matter phase.
C48161	Force	Physical_Phenomena_or_Properties	Force	The influence that produces a change in a physical quantity.
C48162	G_Force	Force	G Force|g	Inertial force produced by accelerations or gravity, expressed in gravitational units; one G is equal to the pull of gravity at the earth's surface at sea level and 45 degrees North latitude (32.1725 ft/sec2; 980.621 cm/sec2). (On-line Medical Dictionary)
C48163	Embed_Technique	Histological_Techniques	Embed|Embed Technique|Embedded|Imbed|Imbedded	To surround an object with a firm chemical substance such as wax or resin, in order to perform cutting of thin sections for microscopic examination. (On-line Medical Dictionary)
C48164	Medium_Material	Substance	Medium	A substance holding another substance in solution or suspension.
C48165	Thaw_Technique	Techniques	Thaw|Thaw Technique	The process whereby heat changes something from a solid to a liquid.
C48166	Disposal_Technique	Techniques	Disposal|Disposal Technique	The act or means of getting rid of something.
C48167	Transfer_Activity	Techniques	Transfer|Transfer Technique|Transport	The act of moving something from one location to another.
C48168	Cancer_Research_Group	Professional_Organization_or_Group	Cancer Research Group|CRG	A collection of scientist and/or clinician users with a common research objective related to diagnosis and treatment of cancer.
C48169	Absorbance_at_260	Molecular_Biology_Techniques	Absorbance at 260nm|OD260	The quantity of 260nm light that is not transmitted through a substance or solution.  In nucleic acid chemistry, this measure is proportional to the concentration of nucleic acid in solution.
C48170	Absorbance_at_280	Molecular_Biology_Techniques	Absorbance at 280nm|OD280	The quantity of 280nm light that is not transmitted through a substance or solution.  In nucleic acid chemistry, the ratio of absorbance of 280nm frequency to 260nm frequency light can be related to nucleic acid purity.
C48171	_28S_Ribosomal_RNA	Ribosomal_RNA	28S Ribosomal RNA|28S RNA	The largest of the three RNA components of the mammalian ribosome.
C48172	_18S_Ribosomal_RNA	Ribosomal_RNA	18S Ribosomal RNA|18S RNA	The second largest of the three RNA components of the mammalian ribosome.
C48173	Visible	General_Modifier	Visible	Perceptible especially by the eye; open to easy view.
C48174	Loading_Technique	Techniques	Loading|Loading Technique	The act of adding a substance or object into something.
C48175	Example	Conceptual_Entities	Example	A representative form or pattern.
C48176	Step	Conceptual_Entities	Step	A specific stage of progression through a sequential process.
C48177	Processing_Technique	Techniques	Processing|Processing Technique	The act of preparing or putting through a prescribed procedure.
C48178	Lesion_Less_than_10mm_in_Diameter	Lesion_with_Diameter_of_10mm_or_Less	Lesion Less than 10mm in Diameter
C48179	Image	NCI_Administrative_Concepts	Image	Any record of an imaging event whether physical or electronic.
C48181	Molecular_Signature	Biomarker	Molecular Signature	A form of gene and protein expression profiling that is indicative of the biological behavior of a tumor or cancer. This pattern of expression is comprised of unique clusters of genes and proteins that display differential levels of expression.
C48182	Gene_Signature	Molecular_Signature	Gene Signature	A form of gene expression profiling that is indicative of the biological behavior of a tumor or cancer. This pattern of expression is comprised of unique clusters of genes that display differential levels of expression. The technology is based on microarray analysis and allows for accurate prognostication based upon these criteria.
C48183	Let-7	Small_RNA	Let-7	A microRNA that has seven isofoms and is known to be a regulator of the RAS oncogene. The length of the miRNA is ~22 nucleotides, and the 3' UTR is the mechanistic path of regulation. The let-7 isoforms have been implicated in a variety of cancers, including lung and breast.
C48184	Retroperitoneal_Lymph_Node_Dissection	Lymph_Node_Dissection	Retroperitoneal Lymph Node Dissection|RPLND	The surgical removal of retroperitoneal lymph nodes from the abdominal cavity. The surgery is a therapeutic treatment for testicular cancer, performed after (orchiectomy) or testicular removal. The surgery is recommended for men who are at an increased risk of metastasis, or who decline other treatment options such as radiation or chemotherapy.
C48185	Neoangiogenesis	Angiogenesis	Neoangiogenesis	The formation of new or recent blood vessels. The vasculature network is critical to the development of neoplasms. As the tumor burden grows, vascular endothial cells are recruited to form new blood vessels as an increased demand for blood and nourishment is required.
C48186	Epigenetic_Silencing	Epigenetic_Process	Epigenetic Silencing	This process is initiated by the formation of heterochromatin which ultimately leads to transcriptional inactivation or silencing. Once formed, heterochromatin can be inherited through many cell divisions, including meiosis. Inappropriate gain of heterochromatin structure, such as the inactivation of tumor suppressor genes by DNA hyper-methylation at their promoter regions, can be directly linked to carcinogenesis.
C48187	Material	Conceptual_Entities	Material	The tangible substance that goes into the makeup of a physical object.
C48188	Raw	General_Modifier	Raw|Unaltered|Unprocessed	Not processed or refined.
C48189	Genomic_Instability	Molecular_Genetic_Abnormality	Genomic Instability	A biological process consisting of chromosomal rearrangements and duplications. These phenotypes are often seen in the karyotype of cancer cells, where there is an imbalance between the mechanisms of cell-cycle control and mutation rates within aberrant genes. Ataxia telangiectasia is a disease that is resultant from mutations in the ATM gene, which is a cell cycle checkpoint gene. Nijmegen breakage syndrome is also a disease characterized by chromosomal and genomic instability.
C48190	Absent	Temporal_Modifier	Absent
C48191	Information	Conceptual_Entities	Information|Info	Knowledge derived from study, experience, or instruction that has been gathered or received by communication.
C48192	Importance_Weight	Conceptual_Entities	Importance Weight|Weight	The relative importance granted to something.
C48193	Generator_Dosage_Form	Pharmaceutical_Dosage_Form	Generator Dosage Form|GENERATOR|Generator Dose Form	An apparatus for the formation of vapor or gas from a liquid or solid by heat or chemical action. The term GENERATOR also applies to radioactive columns from which radionuclides are provided.
C48194	Cholecalciferol	Vitamin_D	Cholecalciferol|(3beta,5Z,7E)-9,10-Secocholesta-5,7,10(19)-trien-3-ol|Calciol|Vitamin D3
C48195	Chromosomal_Instability	Chromosomal_Aberration	Chromosomal Instability|Chromosome Instability	The instability of chromosomes is attributed to the continuous formation of novel chromosome mutations. These mutations form at an elevated rate in comparison to the normal cell population. The increased frequency of structural chromosome aberrations can be caused by an abnormally high incidence of DNA double-strand breaks and translocations. Screening for chromosomal breakage and rearrangement is used as a diagnostic tool in Fanconi anemia.
C48196	DNA_Replication_Fork	DNA_Replication_Factor	DNA Replication Fork	DNA replication is a process that allows two new double helixes of DNA to be created from one double helix. During replication, Y-shaped regions of replicating DNA molecules are mobilized, where the enzymes replicating a DNA molecule bind to an untwisted, single DNA strand. This Y-shaped region is referred to as a replication fork. Bacteria and viruses only process one replication fork at a time, while eukaryotic DNA has many replication forks moving along DNA strands at the same time.
C48197	Intravasation	Cellular_Process	Intravasation	The entry of a foreign object into a blood vessel. This process is pertinent to the description of a cancer cell and its transit into a blood vessel for metastasis at other sites, or to begin neoangiogenesis.
C48198	Extravasation	Biological_Process	Extravasation	The act of utilizing force to transit a vessel into the surrounding environment. This process is pertinent to the description of a cancer cell and its transit out of a blood vessel for metastasis at other sites. This process often initiates micro-metastases in the surrounding tissue.
C48199	Cell_Microenvironment	Conceptual_Entities	Cell Microenvironment|Cellular Microenvironment	The complex relationships between tumor cells and the neighboring cells in the host environment. Cellular signaling within the microenvironment can promote the continuing survival and growth of tumor cells, or apoptosis (cell death). Research is currently underway to manipulate this relationship by altering the host environment in ways that silence or inhibit pro-survival signals concurrent with standard therapies.
C48200	Phenocopy_Alteration	Alteration	Phenocopy Alteration	Observable properties of genetic character, changed or induced by a modification. The resultant progeny inherits physical distinctive traits indicative of the specific parent gene. The source of alteration can be environmental, or due to internal aberration such as a mutation.
C48201	Orphan_Drug	Pharmacologic_Substance	Orphan Drug	A compound or product that demonstrates promise for the diagnosis and/or treatment of rare diseases and conditions that affect fewer than 200,000 people. The U.S. Orphan Drug Act (1983) encourages development of these therapeutics by tax breaks and a seven-year monopoly on drug sales. These incentives promote the development and manufacturing of such therapeutics, which otherwise might not be profitable because of the small potential market.
C48202	Nested_Case-control_Study	Study_Design	Nested Case-control Study	A study in which a group or cohort of individuals is followed for a certain length of time or until a specific outcome is reached. Studies of this type incorporate the strengths of both cohort and case-control studies but eliminates a portion of the methodologic challenges inherent in both types of studies.
C48203	Nanoparticle-targeted_Drug	Drug_Vehicle	Nanoparticle-targeted Drug	A complex consisting of a therapeutic entity coupled to a nanoparticle that has an external coating designed to deliver the therapeutic to a precise location in the body.  This complex is attractive because of the ability to deliver drugs in a controlled fashion to a specific site of interest, and because imaging and contrast agents can be delivered to specific organs and sites for MRI and other studies.
C48204	Norton-Simon_Model	Cancer_Model	Norton-Simon Model	A series of mathematical equations that relates the growth rate of tumors to the way they respond to therapy. The model is frequently utilized to design clinical treatments that are superior to conventional therapies.
C48205	Synchrotron	Instrumentation	Synchrotron	A device that accelerates particles in a circular orbit at a fixed radius. The acceleration is performed in an increasing magnetic field by means of an alternating electric field applied in conjunction with the orbital motion. This device has been utilized to delineate the structure of proteins involved in a variety of cancers and diseases.
C48206	Performed_By	General_Modifier	Performed By	Indicates the person, group, or institution who carried out the action.
C48207	Unit_of_Concentration	Unit_by_Category	Unit of Concentration|Concentration Unit	An indication of the type of unit of measure being used to express a concentration.
C48208	Unit_of_Weight	Unit_by_Category	Unit of Weight|Weight Unit	An indication of the type of unit of measure being used to express a weight.
C48209	Laboratory_Information_Management_System	Computer_System	Laboratory Information Management System|LIMS	Integrated computer systems that are used in the laboratory for the management of samples, laboratory users, instruments, standards and other laboratory functions such as invoicing, plate management, and work flow automation. (from Wikipedia)
C48210	Alpha-methylacyl-CoA_Racemase_Gene	Oxidoreductase_Gene	AMACR Gene|2-methylacyl-CoA Racemase Gene|Alpha-methylacyl-CoA Racemase Gene|RACE|X-methylacyl-CoA Racemase Gene	The human alpha-methylacyl-CoA racemase gene (AMACR) is located on chromosome 5p13 and is ~20 Kb in length.  The gene encodes human AMACAR protein and is localized intracellularly in the cytoplasm of organelles, and has been identified as a molecular marker for prostatic, colon, and breast cancers. Sequence variants of the gene have been associated with cancer risk.
C48211	Alpha-methylacyl-CoA_Racemase	Oxygenase	Alpha-methylacyl-CoA Racemase|2-methylacyl-CoA Racemase|AMACR|X-methylacyl-CoA Racemase	Human alpha-methylacyl-CoA racemase protein (382 aa, ~42.4 kDa) is encoded by the AMCAR gene (AMACR). This protein is an enzyme that is involved in the beta-oxidation of branched-chain fatty acids. Overexpression of this protein has been found in several carcinomas, thus it is considered an important biomarker in the pathogenesis of breast, prostate, and colon cancers.
C48212	Testicular_Germ_Cell_Tumor-1_Gene	Susceptibility-Resistance_Gene	TGCT1 Gene|Testicular Germ Cell Tumor 1|Testicular Germ Cell Tumor Susceptibility 1|Testicular Germ Cell Tumor-1 Gene	Human Testicular Germ Cell Tumor-1 (TGCT1) is located on the X chromosome (Xq27). This gene has a strong correlation with the onset of familial testicular cancer, and has been identified as a susceptibility gene.
C48213	Vascular_Cell_Adhesion_Molecule-1_Gene	Cell_Adhesion_Molecule_Gene	VCAM1 Gene|INCAM-100|VCAM|Vascular Cell Adhesion Molecule-1 Gene	The human vascular cell adhesion molecule-1 gene (VCAM1) is located on chromosome 1p21 and is ~19.3 Kb in length. The gene encodes human VCAM-1 protein; is localized in cardiovascular and epithelial tissues, and is a cell adhesion regulator.
C48214	Vascular_Cell_Adhesion_Molecule-1	Cell_Adhesion_Molecule	Vascular Cell Adhesion Molecule-1|CD106 Antigen|INCAM-100|V-CAM 1	Human vascular cell adhesion molecule-1 protein (739 aa, ~81 kDa) is encoded by the VCAM-1 gene (VCAM1). The protein is a ligand for integrins, which are specific binding molecules in the extracelullar matrix. VCAM-1 promotes the adhesion of immune cells and it is a molecular target for several pharmaceutical compounds.
C48215	Poly_ADP_ribose_Polymerase	DNA_Repair_Protein	Poly(ADP Ribose) Polymerase|PARP|PARP-1	The human protein poly(ADP ribose) polymerase protein (1013aa, ~113 kDa) is encoded by the PARP1 gene (PARP1). Poly(ADP ribose) polymerase (PARP) is a cytosolic protein, and when activated is cleaved into two fragments of 89kd and 24kd. The enzyme modifies various nuclear proteins by poly(ADP-rybosyl)ation. The protein is involved in the regulation of various important cellular processes such as differentiation, proliferation, tumor transformation, and recovery from DNA damage. Its inhibition has been studied in cancerous cells and degenerative diseases to demonstrate how apoptosis can be inhibited when the PARP is inactive or absent.
C48216	ADAM_17	Metalloproteinase	ADAM 17|A disintegrin and metalloproteinase domain 17	The human ADAM 17 protein (824aa, ~93 kDa) is encoded by the Adam17 gene (ADAM17). The protein is ubiquitously expressed, and is a proteolytic enzyme that cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form.  It is also responsible for the proteolytic release of several other cell-surface proteins.  The protein is located on the extracellular face of the cell membrane, and must be membrane bound to cleave its substrates.
C48217	ADAM17_Gene	Metalloproteinase_Gene	ADAM17 Gene|A Disintegrin and Metalloproteinase Domain 17 (Tumor Necrosis Factor, Alpha, Converting Enzyme) Gene|TACE Gene|TNF-alpha Convertase	The human ADAM17 gene is located on chromosome 2p25 and is ~66.5 Kb in length. The gene is located extracellularly, and is ubiquitously expressed.  It belongs to a family of disintegrin and metalloproteinase molecules, and is involved in the malignant transformation of mammary cells.
C48218	Forkhead_Box_C2_Gene	Transcription_Factor_Gene	FOXC2 Gene|FKHL14|FOXC2|Forkhead Box C2 Gene|MFH1	Human FOXC2 is located on chromosome 16q24 and is ~1.5 Kb in length. This gene is localized to the nucleus and to chromatin/chromosome complexes. FOXC2 is an embryonic transcriptional regulator and plays a role in adipocyte metabolism by increasing the sensitivity of the beta-adremergic CAMP protein kinase A. The expression of FOXC2 is upregulated in breast cancers, and has been designated an important molecular target in metastatic capability.
C48219	Personalized	General_Modifier	Personalized	Made for or directed or adjusted to a particular individual.
C48221	Forkhead_Box_C2	cAMP_Responsive_Element_Binding_Protein	Forkhead Box Protein C2|Mesenchyme Fork Head Protein 1|Transcription Factor FKH-14	The human forkhead box C2 protein (501aa, ~53 kDa) is encoded by the forkhead box C2 gene (FOXC2). The protein is involved in the formation of special mesenchymal tissues, and has been isolated in the nucleus. The protein also plays a role in adipocyte metabolism by increasing the sensitivity of the beta-adremergic CAMP protein kinase A.
C48222	Read	Clinical_or_Research_Activity	Read	The act of interpreting something that is written or printed.
C48223	Plug	Conceptual_Entities	Plug	An object designed to fill a hole tightly; anything that resembles such an object in appearance or origin.
C48224	Grading_System	Classification	Grading System
C48226	Efficacy_Lack	Treatment_Efficacy	Efficacy Lack	The lack of expected or desired effect related to a therapy.
C48227	Lost_To_Follow_Up	Clinical_or_Research_Activity	Lost To Follow-up	The loss or lack of continuation of follow-up after a study has officially closed.  See Follow-up.
C48228	Threshold	Conceptual_Entities	Threshold	The lower limit of perception of a stimulus.
C48229	Multiplier	Number	Multiplier	A number by which another number is multiplied.
C48230	JPEG	Lossy_Compression	JPEG	A file compression format mostly used for color and greyscale photographs.
C48232	Cancer_TNM_Finding	Finding	Cancer TNM Finding
C48233	Cancer_TNM_Finding_by_Site	Cancer_TNM_Finding	Cancer TNM Finding by Site
C48234	Prostate_Cancer_TNM_Finding	Cancer_TNM_Finding_by_Site	Prostate Cancer TNM Finding|Cancer of the Prostate TNM Finding|Carcinoma of the Prostate TNM Finding|Prostate Carcinoma TNM Finding
C48235	Prostate_Cancer_Pathologic_TNM_Finding	Prostate_Cancer_TNM_Finding	Prostate Cancer Pathologic TNM Finding
C48236	Prostate_Cancer_pT2_TNM_Finding	Prostate_Cancer_Pathologic_TNM_Finding	Prostate Cancer pT2 TNM Finding	Prostate cancer confined to the prostate gland. (from AJCC 6th Ed.)
C48237	Prostate_Cancer_pT2a_TNM_Finding	Prostate_Cancer_pT2_TNM_Finding	Prostate Cancer pT2a TNM Finding	Prostate cancer limited to one-half or less of one lobe of the prostate gland. (from AJCC 6th Ed.)
C48238	Prostate_Cancer_pT2b_TNM_Finding	Prostate_Cancer_pT2_TNM_Finding	Prostate Cancer pT2b TNM Finding	Prostate cancer involving more than one-half of one lobe, but not both lobes of the prostate gland. (from AJCC 6th Ed.)
C48239	Prostate_Cancer_pT2c_TNM_Finding	Prostate_Cancer_pT2_TNM_Finding	Prostate Cancer pT2c TNM Finding	Prostate cancer involving both lobes of the prostate gland. (from AJCC 6th Ed.)
C48240	Prostate_Cancer_pT3_TNM_Finding	Prostate_Cancer_Pathologic_TNM_Finding	Prostate Cancer pT3 TNM Finding	Prostate cancer extending beyond the capsule of the prostate gland. (from AJCC 6th Ed.)
C48241	Prostate_Cancer_pT3a_TNM_Finding	Prostate_Cancer_pT3_TNM_Finding	Prostate Cancer pT3a TNM Finding	Prostate cancer extending beyond the capsule of the prostate gland, without involvement of the seminal vesicles. (from AJCC 6th Ed.)
C48242	Prostate_Cancer_pT3b_TNM_Finding	Prostate_Cancer_pT3_TNM_Finding	Prostate Cancer pT3b TNM Finding	Prostate cancer extending beyond the capsule of the prostate gland, with involvement of the seminal vesicles. (from AJCC 6th Ed.)
C48243	Prostate_Cancer_pT4_TNM_Finding	Prostate_Cancer_Pathologic_TNM_Finding	Prostate Cancer pT4 TNM Finding	Prostate cancer extending beyond the capsule of the prostate gland, with involvement of the bladder and/or rectum. (from AJCC 6th Ed.)
C48244	Prostate_Cancer_pN0_TNM_Finding	Prostate_Cancer_Pathologic_TNM_Finding	Prostate Cancer pN0 TNM Finding	Prostate cancer without involvement of regional lymph nodes. (from AJCC 6th Ed.)
C48245	Prostate_Cancer_pN1_TNM_Finding	Prostate_Cancer_Pathologic_TNM_Finding	Prostate Cancer pN1 TNM Finding	Prostate cancer with involvement of regional lymph nodes. (from AJCC 6th Ed.)
C48246	Prostate_Cancer_pM1_TNM_Finding	Prostate_Cancer_Pathologic_TNM_Finding	Prostate Cancer pM1 TNM Finding	Prostate cancer with metastasis to one or more distant sites. (from AJCC 6th Ed.)
C48248	Prostate_Cancer_pM1b_TNM_Finding	Prostate_Cancer_pM1_TNM_Finding	Prostate Cancer pM1b TNM Finding	Prostate cancer with metastasis to bone. (from AJCC 6th Ed.)
C48249	Prostate_Cancer_pM1c_TNM_Finding	Prostate_Cancer_pM1_TNM_Finding	Prostate Cancer pM1c TNM Finding	Prostate cancer with metastasis to distant sites other than bone and/or non-regional lymph nodes. (from AJCC 6th Ed.)
C48250	Physician_Decision	Clinical_or_Research_Activity	Physician Decision
C48251	Protocol_Violation	Research_Activity	Protocol Violation
C48256	Prostate_Cancer_pM1a_TNM_Finding	Prostate_Cancer_pM1_TNM_Finding	Prostate Cancer pM1a TNM Finding	Prostate cancer with metastasis to non-regional lymph nodes. (from AJCC 6th Ed.)
C48257	Parathyroid_Gland_Parenchymal_Cell	Endocrine_Cell_and_Neuroendocrine_Cell|Glandular_Cell	Parathyroid Gland Parenchymal Cell
C48258	Parathyroid_Gland_Epithelial_Tissue	Glandular_Epithelial_Tissue|Parathyroid_Gland_Tissue	Parathyroid Gland Epithelial Tissue
C48259	Hyperparathyroidism	Non-Neoplastic_Parathyroid_Gland_Disorder	Hyperparathyroidism
C48260	Perineural_Invasion	Morphologic_Finding	Perineural Invasion
C48261	Screening_Generic	Clinical_or_Research_Activity	Screening_Generic	A systematic examination or assessment.
C48262	Trial_Screening	Screening	Trial Screening	A process of active consideration of potential subjects for enrollment in a trial.
C48263	I_131_TM-601	Radioconjugate	I 131 TM-601
C48264	Talabostat	Enzyme_Inhibitor	Talabostat	An orally active small molecule drug with anti-tumor activity and potent hematopoietic stimulating activity. Talabostat is an inhibitor of dipeptidyl peptidases, such as fibroblast activation protein (FAP), which are involved in the activation of polypeptide hormones and chemokines by cleaving N-terminal Xaa-Pro or Xaa-Ala. Upon administration, talabostat stimulates cytokine and chemokine production resulting in specific T-cell immunity and T-cell dependent activity. Talabostat could be used in combination with chemotherapeutic agents, monoclonal antibodies, and vaccines to enhance their anti-tumor activity. (NCI05)
C48265	Neoplastic_Parathyroid_Gland_Cell	Neoplastic_Endocrine_Cell|Neoplastic_Glandular_Cell	Neoplastic Parathyroid Gland Cell
C48266	Malignant_Parathyroid_Gland_Cell	Adenocarcinoma_Cell|Malignant_Endocrine_Cell|Neoplastic_Parathyroid_Gland_Cell	Malignant Parathyroid Gland Cell
C48268	Neoplastic_Parathyroid_Gland_Chief_Cell	Neoplastic_Parathyroid_Gland_Cell	Neoplastic Parathyroid Gland Chief Cell
C48269	Malignant_Parathyroid_Gland_Chief_Cell	Malignant_Parathyroid_Gland_Cell|Neoplastic_Parathyroid_Gland_Chief_Cell	Malignant Parathyroid Gland Chief Cell
C48270	Malignant_Parathyroid_Gland_Clear_Cell	Adenocarcinoma_Clear_Cell|Malignant_Parathyroid_Gland_Cell|Neoplastic_Parathyroid_Gland_Clear_Cell	Malignant Parathyroid Gland Clear Cell
C48271	Consent_Withdrawn	Consent	Consent Withdrawn	When the permission to do something is rescinded or withdrawn.
C48272	Neoplastic_Parathyroid_Gland_Oncocyte	Neoplastic_Oncocyte|Neoplastic_Parathyroid_Gland_Cell	Neoplastic Parathyroid Gland Oncocyte
C48273	Malignant_Parathyroid_Gland_Oncocyte	Malignant_Oncocyte|Malignant_Parathyroid_Gland_Cell|Neoplastic_Parathyroid_Gland_Oncocyte	Malignant Parathyroid Gland Oncocyte
C48274	Cancer_Molecular_Analysis_Project	Cancer_Research_Project	Cancer Molecular Analysis Project|CMAP	Through the Cancer Molecular Analysis Project (CMAP), NCI facilitates the identification and evaluation of molecular targets by integrating comprehensive molecular characterizations of cancer and making the data and infrastructure publicly accessible. CMAP permits investigators to 1) Discover molecular targets, 2) Assess their validity and interaction with other targets, 3) Determine if there are therapeutic agents that can act on specific targets, 4) Screen for possible toxicity, and 5) Determine whether there are clinical trials evaluating these agents. (http://plan2005.cancer.gov/bioinformatics.html)
C48275	Death_Related_to_Adverse_Event	Adverse_Event	Death Related to Adverse Event
C48276	Adverse_Event_Classification	Classification	Adverse Event Classification	The systematic arrangement of adverse events based on common characteristics such as properties and outcomes.
C48279	Neoplastic_Parathyroid_Gland_Clear_Cell	Neoplastic_Glandular_Cell_with_Clear_Cytoplasm|Neoplastic_Parathyroid_Gland_Cell	Neoplastic Parathyroid Gland Clear Cell
C48280	Primary_Hyperparathyroidism	Hyperparathyroidism	Primary Hyperparathyroidism
C48281	Trial_Phase	Classification	Trial_Phase_Classification|Trial Phase
C48282	_2-Dimensional	Properties_or_Attributes	2-Dimensional|2D	The property of being measured and described using two orthogonal directions.
C48283	Parathyroid_Gland_Lipoadenoma	Lipoadenoma|Parathyroid_Adenoma	Parathyroid Gland Lipoadenoma	A parathyroid gland adenoma that contains mature adipocytes. (NCI05)
C48284	Donor_Generic	General_Modifier	Donor	One that contributes something.
C48285	Parathyroid_Gland_Atypical_Adenoma	Parathyroid_Adenoma	Parathyroid Gland Atypical Adenoma	A parathyroid gland tumor that shares certain morphologic characteristics with parathyroid gland carcinomas (e.g. broad fibrous bands formation with or without hemosiderin deposition, presence of mitotic figures) but lacks unequivocal evidence of capsular or vascular invasion.  It is considered a tumor of uncertain malignant potential (adapted from WHO, IARC Press, Lyon, 2004). (NCI05)
C48286	Broad_Fibrous_Bands_Formation	Fibrotic_Stroma_Formation	Broad Fibrous Bands Formation
C48287	Hyperparathyroidism-Jaw_Tumor_Syndrome	Hereditary_Neoplastic_Syndrome	Hyperparathyroidism-Jaw Tumor Syndrome|HPT-JT
C48288	Stock	Conceptual_Entities	Stock	The merchandise that a shop has on hand.
C48289	Distributor	Person	Distributor	A person or group with authority to allot or deal out or apportion.
C48290	Tool_Mouse	Laboratory_Animal	Tool Mouse	A mouse strain that does not develop tumors, but can be used in generating tumor bearing strains.
C48291	Character_Large_Object	Data_Type	Character Large Object|CLOB	A data type for holding large chunks of text.
C48292	Curate_Activity	Clinical_or_Research_Activity	Curation|Curate	To organize and oversee.
C48293	Execution_Activity	Clinical_or_Research_Activity	Execution|Execute	The act of carrying out some order or instruction to accomplish an aim.
C48294	Reference_Object	Conceptual_Entities	Reference Object|Reference|Referenced|Referent	Something referred to; the object of a reference.
C48295	Fragment	Conceptual_Entities	Fragment	A part of a larger entity.
C48296	Hashtable	Array	Hashtable|Hash Table	An associative array data structure that associates keys with values.
C48297	Server	Computers	Server	A computer which provides some service for other computers connected to it via a network. (Free On-line Dictionary of Computing)
C48298	Nomenclature	Information_Sciences	Nomenclature	A system of words used in a particular discipline.
C48299	Mouse_Genome_Informatics	Information_Resources	Mouse Genome Informatics|MGI	A resource of the Jackson lab, provides integrated access to data on the genetics, genomics, and biology of the laboratory mouse.
C48300	Hereditary_Paraganglioma-Pheochromocytoma_Syndrome	Endocrine_Syndrome|Hereditary_Neoplastic_Syndrome	Hereditary Paraganglioma-Pheochromocytoma Syndrome|Familiar Paraganglioma-Pheochromocytoma Syndrome
C48301	Mitochondrial_Complex_II_Gene_Mutation	Gene_Abnormality	Mitochondrial Complex II Gene Mutation
C48302	SDHB_Gene_Mutation	Mitochondrial_Complex_II_Gene_Mutation	SDHB Gene Mutation
C48303	SDHC_Gene_Mutation	Mitochondrial_Complex_II_Gene_Mutation	SDHC Gene Mutation
C48304	SDHD_Gene_Mutation	Mitochondrial_Complex_II_Gene_Mutation	SDHD Gene Mutation
C48305	Benign_Adrenal_Gland_Pheochromocytoma	Benign_Adrenal_Medulla_Neoplasm|Benign_Paraganglionic_Neoplasm|Pheochromocytoma	Benign Adrenal Gland Pheochromocytoma	A sporadic or familiar pheochromocytoma that is confined to the adrenal gland and does not have any metastatic potential.  The majority of cases are sporadic, and usually unilateral.  Familiar cases are usually bilateral. (NCI05)
C48306	Adrenal_Gland_Composite_Pheochromocytoma	Pheochromocytoma	Adrenal Gland Composite Pheochromocytoma	A benign or malignant neoplasm arising from the adrenal medulla.  It combines morphologic characteristics of pheochromocytoma and neuroectodermal tumors such as neuroblastoma, ganglioneuroma, ganglioneuroblastoma, or peripheral nerve sheath tumors. (NCI05)
C48307	Spontaneous	General_Modifier	Spontaneous	Happening or arising without apparent external cause.
C48308	Stage_Generic	Temporal_Modifier	Stage	Any distinct time period in a sequence of events.
C48309	Grade	Properties_or_Attributes	Grade	A position on a scale of intensity or amount or quality.
C48310	Manipulation	Clinical_or_Research_Activity	Manipulation|Manipulate	Move, treat, or operate with the hands or by mechanical means, especially in a skillful manner.
C48311	Long_Value	Data_Type	Long|Long Value|Long Variable	A variable that is stored as a signed 64-bit (8-byte) integer.
C48312	Request	Conceptual_Entities	Request|Requested	Express the need or desire for; ask for.
C48313	Suggestion	Conceptual_Entities	Suggestion|Suggest	A proposal offered for acceptance or rejection.
C48314	Benign_Paraganglionic_Neoplasm	Paraganglionic_Neoplasm	Benign Paraganglioma|Benign Paraganglionic Neoplasm	A paraganglioma that is confined to the site of origin, without metastatic potential.
C48316	Nasopharyngeal_Paraganglioma	Head_and_Neck_Paraganglioma|Nasopharyngeal_Neoplasm	Nasopharyngeal Paraganglioma	A benign or malignant extra-adrenal paraganglioma arising from the nasopharynx and nose.  Epistaxis or nasal obstruction are common presenting symptoms.
C48317	Superior_and_Inferior_Paraaortic_Paraganglioma	Extra-Adrenal_Retroperitoneal_Paragangliomas	Superior and Inferior Paraaortic Paraganglioma	A benign or malignant extra-adrenal sympathetic paraganglioma arising from paraganglia located along the aorta, including suprarenal, infrarenal, and renal hilar sites.  In functional tumors, the hypersecretion of catecholamines results in hypertension.
C48318	Cerebellar_Paraganglioma	Central_Nervous_System_Paraganglioma|Cerebellar_Neoplasm	Cerebellar Paraganglioma	A benign or malignant extra-adrenal paraganglioma arising from the cerebellum.
C48319	Adrenal_Gland_Adenomatoid_Tumor	Adenomatoid_Tumor|Benign_Adrenal_Gland_Neoplasm	Adrenal Gland Adenomatoid Tumor	A benign neoplasm probably arising from mesothelial inclusions in the adrenal gland tissue. (NCI05)
C48320	Adrenal_Gland_Angiosarcoma	Angiosarcoma|Malignant_Adrenal_Gland_Neoplasm	Adrenal Gland Angiosarcoma	A rare malignant soft tissue neoplasm arising from the vascular endothelium of the adrenal gland. (NCI05)
C48322	Primary_Site_Unknown	Test_Result	Primary Site Unknown
C48323	Black	Structured_Product_Labeling_Color	Black|BLACK	rgb(0, 0, 0)
C48324	Gray_Color	Structured_Product_Labeling_Color	Gray|GRAY|Gray Color	rgb(128, 128, 128)
C48325	White_Color	Structured_Product_Labeling_Color	White|WHITE|White Color	rgb(255, 255, 255)
C48326	Red	Structured_Product_Labeling_Color	Red|RED	rgb(255, 0, 0)
C48327	Purple	Structured_Product_Labeling_Color	Purple|PURPLE	rgb(128, 0, 128)
C48328	Pink	Structured_Product_Labeling_Color	Pink|PINK	rgb(255, 192, 203)
C48329	Green	Structured_Product_Labeling_Color	Green|GREEN	rgb(0, 128, 0)
C48330	Yellow	Structured_Product_Labeling_Color	Yellow|YELLOW	rgb(255, 255, 0)
C48331	Orange	Structured_Product_Labeling_Color	Orange|ORANGE	rgb(255, 165, 0)
C48332	Brown	Structured_Product_Labeling_Color	Brown|BROWN	rgb(165, 42, 42)
C48333	Blue	Structured_Product_Labeling_Color	Blue|BLUE	rgb(0, 0, 255)
C48334	Turquoise	Structured_Product_Labeling_Color	Turquoise|TURQOUISE	rgb(64. 224, 208)
C48335	Bullet	Structured_Product_Labeling_Shape	Bullet|BULLET	The shape of a cylinder when viewing the capsule from a point perpendicular to its longest side, with a point at one end.  The bullet shape is synonymous with torpedo shape.
C48336	Capsule_Shape	Structured_Product_Labeling_Shape	Capsule Shape|CAPSULE	The shape of a capsule when viewing the capsule from a point perpendicular to its longest side.  The capsule shape is reserved for two-part capsules and banded two-part capsules. Tablets with a capsule shape or a one part capsules (e.g., soft gelatin capsules that are filled with a liquid) should be classified under OVAL.
C48337	Clover	Structured_Product_Labeling_Shape	Clover|CLOVER	The stylized shape, of clover, having three or four leaves with or without the stem.
C48338	Diamond	Structured_Product_Labeling_Shape	Diamond|DIAMOND	The shape has four distinct sides making a parallelogram with two inner obtuse angles and two inner acute angles.  A square with diagonal imprinting is not a diamond, but rather, a square.  See also SQUARE.
C48339	Double_Circle	Structured_Product_Labeling_Shape	Double Circle|DOUBLE CIRCLE	The shape of two circles joined together, and usually overlapping.
C48340	Freeform	Structured_Product_Labeling_Shape	Freeform|FREEFORM	The shape does not have 3 or more distinct sides and is not one of the listed shapes.  Examples include, but are not limited to, airplane, apple, cartoon characters, heart, kidney, shield, and train shapes.
C48341	Gear	Structured_Product_Labeling_Shape	Gear|GEAR	The two dimensional shape of a toothed wheel of a machine part.
C48342	Heptagon	Structured_Product_Labeling_Shape	Heptagon|HEPTAGON (7 sided)	The shape has seven distinct sides. The sides may be straight or slightly curved.  It can either be regular (interior angles are equal and its sides are equal in length) or irregular (interior angles are not equal and/or its sides are not equal in length).
C48343	Hexagon	Structured_Product_Labeling_Shape	Hexagon|HEXAGON (6 sided)	The shape has six distinct sides. The sides may be straight or slightly curved.  It can either be regular (interior angles are equal and its sides are equal in length) or irregular (interior angles are not equal and/or its sides are not equal in length).
C48344	Octagon	Structured_Product_Labeling_Shape	Octagon|OCTAGON (8 sided)	The shape has eight distinct sides. The sides may be straight or slightly curved. It can either be regular (interior angles are equal and its sides are equal in length) or irregular (interior angles are not equal and/or its sides are not equal in length).
C48345	Oval	Structured_Product_Labeling_Shape	Oval|OVAL	The shape of either an oval or an ellipse.  See also TEAR.
C48346	Pentagon	Structured_Product_Labeling_Shape	Pentagon|PENTAGON (5 sided)	The shape has five distinct sides. The sides may be straight or slightly curved. It can either be regular (interior angles are equal and its sides are equal in length) or irregular (interior angles are not equal and/or its sides are not equal in length).
C48347	Rectangle	Structured_Product_Labeling_Shape	Rectangle|RECTANGLE	The shape has four distinct sides and four right angles but is not a square.
C48348	Round	Structured_Product_Labeling_Shape	Round|ROUND	The shape of a circle.  Spherical shapes are called round because their two dimensional projections are round.
C48349	Semi-Circle	Structured_Product_Labeling_Shape	Semi-Circle|SEMI-CIRCLE	The shape of half of a circle or half of an oval.  This shape is also used for shapes similar to the letter D or the letter U.  Any letter D or U that is either embossed or debossed onto the surface of a dosage form is not used in determining the shape of that dosage form.
C48350	Square_Shape	Structured_Product_Labeling_Shape	Square Shape|SQUARE	The shape has four distinct and equal sides with four right angles. The sides may be straight or slightly curved.  A square tilted at a 45 degree angle so that the diagonals run vertical and horizontal is not a diamond, but rather, a square.  See also DIAMOND.
C48351	Tear_Shape	Structured_Product_Labeling_Shape	Tear Shape|TEAR	The stylized shape of a tear or drop of water.  It differs from an oval because one end is clearly larger than the other.  It is synonymous with the shapes egg, pear, and almond.  See also oval.
C48352	Trapezoid	Structured_Product_Labeling_Shape	Trapezoid|TRAPEZOID	The shape has four distinct sides. The sides may be straight or slightly curved.  Only two of the sides are parallel.
C48353	Triangle	Structured_Product_Labeling_Shape	Triangle|TRIANGLE	The shape has three distinct sides. The sides may be straight or slightly curved.  It can either be regular (interior angles are equal and its sides are equal in length) or irregular (interior angles are not equal and/or its sides are not equal in length).
C48354	Relational_Operator	Properties_or_Attributes	Relational Operator	A boolean operator used to specify a greater-than, less-than, or equal-to relationship.
C48355	Sponsor	Person	Sponsor|Coordinator	Someone who supports or champions something.
C48356	Reading	Information	Reading	A datum that is presented to a user by a meter or similar instrument.
C48357	Abundant_Intracytoplasmic_Lipofuscin_Present	Morphologic_Finding	Abundant Intracytoplasmic Lipofuscin Present
C48358	Adrenal_Cortical_Cell	Endocrine_Cell_and_Neuroendocrine_Cell|Glandular_Cell	Adrenal Cortical Cell
C48359	Coordinating_Center	Sites_of_Care_Delivery	Coordinating Center	A facility that is responsible for receiving, editing, processing, analyzing, and storing data generated in a study and that, in addition, has responsibility for coordination of activities required for execution of the study. (CPCRA Glossary)
C48360	Frame_of_Reference	Conceptual_Entities	Frame of Reference	A set of ideas, as of philosophical or religious doctrine, in terms of which other ideas are interpreted or assigned meaning; a system that uses coordinates to establish position.
C48361	Neoplastic_Adrenal_Cortical_Cell	Neoplastic_Endocrine_Cell|Neoplastic_Glandular_Cell	Neoplastic Adrenal Cortical Cell
C48362	Neoplastic_Adrenal_Clear_Cell	Neoplastic_Adrenal_Cortical_Cell|Neoplastic_Endocrine_Clear_Cell	Neoplastic Adrenal Cortical Clear Cell|Neoplastic Adrenal Clear Cell
C48363	Malignant_Adrenal_Cortical_Cell	Adenocarcinoma_Cell|Malignant_Endocrine_Cell|Neoplastic_Adrenal_Cortical_Cell	Malignant Adrenal Cortical Cell
C48364	Instance	Conceptual_Entities	Instance	An occurrence of something.
C48365	Neuroendocrine_Tissue	Epithelial_Tissue	Neuroendocrine Tissue
C48366	Lossy_Compression	Algorithms	Lossy Compression	A data compression algorithm that reduces the amount of information in the data, rather than just the number of bits used to represent that information. (from On-Line Dictionary of Computing)
C48367	Pixel	Conceptual_Entities	Pixel|Picture Element	The smallest resolvable rectangular area of an image, either on a screen or stored in memory. (Free On-Line Dictionary of Computing)
C48368	Adenovector_Encoding_MDA7	DNA_Vaccine	Adenovector Encoding MDA7	A nonreplicating adenoviral vector (adenovector) encoding the melanoma differentiation-associated 7 gene (MDA7) with potential antineoplastic activity. After intratumoral injection and adenovector-mediated gene transfer of MDA7 into tumor cells, the expressed MDA7 transgene may inhibit tumor cell proliferation and induce tumor cell apoptosis.
C48369	AEE788	Tyrosine_Kinase_Inhibitor	AEE788|AEE-788	An orally bioavailable multiple-receptor tyrosine kinase inhibitor. AEE788 inhibits phosphorylation of the tyrosine kinases of epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), and vascular endothelial growth factor receptor 2 (VEGF2), resulting in receptor inhibition, the inhibition of cellular proliferation, and induction of tumor cell and tumor-associated endothelial cell apoptosis. (NCI05)
C48370	AFP464	DNA_Adduct_Forming_Agent	AFP464
C48371	Allogeneic_GM-CSF-Secreting_Breast_Cancer_Vaccine	Antineoplastic_Vaccine	Allogeneic GM-CSF-Secreting Breast Cancer Vaccine|GM-CSF BREAST VAC	An allogenic vaccine consisting of irradiated breast cancer cells transfected with the granulocyte macrophage-colony-stimulating factor (GM-CSF) gene. Upon vaccination, the genetically modified cells secrete GM-CSF, thereby potentiating a tumor-specific T cell response against breast cancer cell-associated antigens. (NCI05)
C48372	Alpha_Fetoprotein_Adenoviral_Vector_Vaccine	Antineoplastic_Vaccine	Alpha Fetoprotein Adenoviral Vector Vaccine|AdVhAFP	A vaccine consisting of a recombinant adenoviral vector encoding alpha fetoprotein. After vaccination, expressed alpha fetoprotein may stimulate a cytotoxic T lymphocyte (CTL) response against tumor cells that express alpha fetoprotein, resulting in tumor cell lysis. (NCI05)
C48373	Alpha_Fetoprotein_Plasmid_DNA_Vaccine	DNA_Vaccine	Alpha Fetoprotein Plasmid DNA Vaccine|phAFP	A vaccine consisting of plasmid DNA encoding alpha fetoprotein. After vaccination, expressed alpha fetoprotein may stimulate a cytotoxic T lymphocyte (CTL) response against tumor cells that express alpha fetoprotein, resulting in tumor cell lysis. (NCI05)
C48374	AMG706	Tyrosine_Kinase_Inhibitor	AMG 706|AMG-706	An orally bioavailable multiple-receptor tyrosine kinase inhibitor with potential antineoplastic activity. AMG 706 selectively targets and inhibits vascular endothelial growth factor (VEGFR), platelet-derived growth factor (PDGFR), Kit, and Ret receptors, thereby inhibiting angiogenesis and cellular proliferation. (NCI05)
C48375	AMN107	Antineoplastic_Vaccine	AMN107|4-Methyl-3-((4-(3-pyridinyl)-2-pyrimidinyl)amino)-N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)phenyl)benzamide	An orally available aminopyrimidine with antineoplastic activity. Designed to overcome imatinib resistance, AMN107 is a tyrosine kinase inhibitor that binds to and inhibits the Bcr-Abl fusion protein, an abnormal chimeric tyrosine kinase expressed in Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML) cells . This agent also inhibits the receptor tyrosine kinases for platelet-derived growth factor (PDGF) and for c-kit, a receptor tyrosine kinase activated in gastrointestinal stromal tumor (GIST). AMN107 interrupts phosphorylation of these tyrosine kinases and their downstream signaling targets, resulting in decreased cellular proliferation and the induction of apoptosis. This agent is more potent than imatinib against Ph+ CML cells.
C48376	Autologous_Dendritic_Cell-Allogeneic_Melanoma_Tumor_Cell_Lysate_Vaccine	Antineoplastic_Vaccine	Autologous Dendritic Cell-Allogeneic Melanoma Tumor Cell Lysate Vaccine|IDD-3	A cell-based vaccine composed of autologous dendritic cells pulsed with lysates from allogeneic melanoma tumor cells. Upon administration, this vaccine may stimulate anti-tumoral cytotoxic T-cell and antibody responses to melanoma cells, resulting in tumor cell lysis.
C48377	Autologous_EBV-Transformed_B_Lymphoblastoid-Tumor_Fusion_Cell_Vaccine	Antineoplastic_Vaccine	Autologous EBV-Transformed B Lymphoblastoid-Tumor Fusion Cell Vaccine	A cell-based vaccine composed of autologous tumor cells fused with Epstein-Barr virus-transformed B-lymphoblastoid cells. Upon administration, this vaccine may stimulate a cytotoxic T cell response against tumor cells, resulting in tumor cell lysis. (NCI05)
C48378	AZD0530	Protein_Kinase_Inhibitor	AZD0530
C48379	AZD2171	Tyrosine_Kinase_Inhibitor	AZD2171|AZD-2171	An indole ether quinazoline derivative with antineoplastic properties. Competing with adenosine triphosphate, AZD2171 binds to and inhibits all three vascular endothelial growth factor receptor (VEGF-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth. (NCI05)
C48380	BMS-599626	Tyrosine_Kinase_Inhibitor	BMS-599626	An orally bioavailable pan-HER tyrosine kinase inhibitor with potential antineoplastic activity. BMS-599626 inhibits human epidermal growth factor receptors (HER) HER1, HER2 and HER4, thereby inhibiting the proliferation of tumor cells that overexpress these receptors. (NCI05)
C48381	Bowman-Birk_Inhibitor_Concentrate	Chemopreventive_Agent	Bowman-Birk Inhibitor Concentrate|BBIC	An extract of soybeans enriched in Bowman-Birk inhibitor (BBI), a soybean-derived, 71-amino acid, polypeptide and serine protease inhibitor with potential chemopreventive activity. Bowman-Birk inhibitor contains distinct inhibitory sites for trypsin and chymotrypsin. Although the exact mechanism by which BBI suppresses carcinogenesis is unknown, its antiproliferative activity appears to be linked to the chymotrypsin inhibitory region.
C48382	CDDO	Cyclooxygenase_Inhibitor|Nitric_Oxide_Synthetase_Inhibitor	CDDO|2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid
C48383	CNGRC_Peptide-Tumor_Necrosis_Factor_Alpha_Conjugate	Endothelial_Cell_Inhibitor	CNGRC Peptide-TNF Alpha Conjugate|NGR-hTNF	A cytokine-peptide conjugate composed of the cytokine tumor necrosis factor alpha (TNF-alpha) chemically linked to the peptide CNGRC. The peptide moiety CNGRC, a ligand for the membrane-bound metalloprotease CD13, binds to endothelial cells of the angiogenic vasculature that express CD13 (also known as aminopeptidase N); subsequently, the TNF-alpha moiety induces apoptosis in endothelial cells expressing CD13, thereby inhibiting tumor-associated angiogenesis. (NCI05)
C48384	Deferasirox	Chelating_Agent	Deferasirox|4-(3,5-Bis-(hydroxy-phenyl)-1,2,4)triazol-1-yl)-benzoic Acid|Exjade	A synthetic, orally available, achiral, tridentate triazole derived from salicylic acid with iron chelator properties. Deferasirox chelates iron at a 2:1 (ligand:iron) ratio. Because of its oral availablity,and long plasma half-life, this agent may be superior to desferrioxamine (desferal, DFO), which is orally inactive and has a short plasma half-life.
C48385	Degarelix	Gonadotropin_Releasing_Hormone_Inhibitor	Degarelix|Alaninamide|FE200486|N-acetyl-3-(naphtalen-2-yl)-D-alanyl-4-chloro-D-phenylalanyl-3-(pyridin-3-yl)-D-alanyl-L-seryl-4-((((4S)-2,6-dioxohexahydropyrimidin-4-yl)carbonyl)amino)-L-phenylalanyl-4-(carbamoylamino)-D-phenylalanyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-D-alaninamide	A long-acting, synthetic peptide with gonadotrophin-releasing hormone (GnRH) antagonistic properties. Degarelix targets and blocks GnRH receptors located on the surfaces of gonadotroph cells in the anterior pituitary, thereby reducing secretion of luteinizing hormone (LH) by pituitary gonadotroph cells and so decreasing testosterone production by interstitial (Leydig) cells in the testes.
C48386	Eculizumab	Monoclonal_Antibody	Eculizumab|Alexion|Monoclonal antibody 5G1.1|h5G1.1	A human monoclonal antibody directed against terminal complement protein C5. Eculizumab binds to terminal complement protein C5, thereby blocking C5 cleavage into pro-inflammatory components and blocking the complement-mediated destruction of paroxysmal nocturnal hemoglobinuria (PNH) red blood cells. (NCI05)
C48387	Everolimus	Immunosuppressant	Everolimus|(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-Dihydroxy-12-((1R)-2-((1S,3R,4R)-4-(2-hydroxyethoxy)-3-methoxycyclohexyl)-1-methylethyl)-19,30-dimethoxy-15,17,21,23,29,35-hexamethyl-11,36-dioxa-4-azatricyclo(30.3.1.04,9)hexatriaconta-16,24,26,28-tetraene-2,3,10,14,20-pentaone|42-O-(2-Hydroxy)ethyl Rapamycin|Certican|RAD 001	A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. (NCI05)
C48388	Everolimus_Gefitinib	Chemotherapy_Regimen	Everolimus/Gefitinib|RAD/ZD 1839	A chemotherapy drug combination consisting of everolimus and gefitinib. Everolimus is a proliferation inhibitor with immunosuppressive and anti-angiogenic properties. Gefitinib is an epidermal growth factor receptor (EGFR) inhibitor with anti-angiogenic activity. This combination chemotherapy may result in increased tumor cell death compared to the use of either agent alone. (NCI05)
C48389	Fluorine_F_18_EF5	Radioconjugate	Fluorine F 18 EF5	A radioconjugate consisting of EF5, a fluorinated derivative of etanidazole, conjugated to fluorine F 18, a positron emitting isotope. EF5 binds to hypoxic tissue; conjugation to Fluorine F 18 allows imaging of hypoxic regions within tumors. (NCI05)
C48390	Fowlpox_Virus_Vaccine_Vector	Fowlpox_Virus_Vaccine	Fowlpox Virus Vaccine Vector|FOWLVAC	A recombinant fowlpox virus-based vaccine vector designed to express various tumor-associated peptide antigens. Strong CD8 cytotoxic T cell responses may be induced after prolonged immunization with fowlpox virus vaccines and have been associated with tumor regression. Fowlpox virus is an attractive vector because its genome is easy to manipulate and it does not multiply in human tissues. (NCI05)
C48391	GM_CD40L_Cell_Vaccine	Antineoplastic_Vaccine	GM.CD40L Cell Vaccine|GM.CD40L	A cell-based vaccine composed of irradiated tumor cells transduced with granulocyte-macrophage colony-stimulating factor (GM-CSF) and CD40-ligand (CD40L) genes. Upon administration, this vaccine may stimulate an anti-tumoral dendritic cell-mediated host immune response. (NCI05)
C48392	HER-2-neu_CEA_Peptides_GM-CSF_Montanide_ISA-51_Vaccine	Chemotherapy_Regimen	HER-2-neu, CEA Peptides/GM-CSF, Montanide ISA-51 Vaccine	A vaccine comprised of HER-2-neu and carcinoembryonic antigen synthetic (CEA) peptides, combined with the adjuvants granulocyte-macrophage colony stimulating factor (GM-CSF), and Montanide ISA-51 with potential antineoplastic properties. HER-2-neu, CEA peptides/GM-CSF, Montanide ISA-51 vaccine may stimulate a cytotoxic T-cell response against HER-2-neu- and CEA-expressing tumor cells. The GM-CSF adjuvant stimulates the proliferation of monocytes and monocyte differentiation into macrophages and dendritic cells, immunohematopoietic elements with important antitumoral functions. Montanide ISA-51 (also known as incomplete Freund's adjuvant or IFA), a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant, non-specifically stimulates cell-mediated immune responses to antigens.
C48393	HLA-A1_A2_B35-Restricted_Survivin_Peptides_Montanide_ISA-51_Vaccine	Chemotherapy_Regimen	HLA-A1, A2, B35-Restricted Survivin Peptides/Montanide ISA-51 Vaccine|Survivin Peptide Vaccine	A peptide vaccine comprised of synthetic HLA-A1, -A2 and -B35 restricted survivin epitopes combined with the adjuvant Montanide ISA-51 with potential antineoplastic activity. Upon administration, HLA-A1, -A2 and -B35 restricted survivin peptides/Montanide ISA-51 may stimulate a cytotoxic T cell response against tumor cells that overexpress survivin, resulting in tumor cell lysis. Montanide ISA-51 (also known as incomplete Freund's adjuvant or IFA), a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant, non-specifically stimulates cell-mediated immune responses to antigens.
C48394	HLA-A2_A3-Restricted_FGF-5_Peptides_Montanide_ISA-51_Vaccine	Chemotherapy_Regimen	HLA-A2, A3-Restricted FGF-5 Peptides/Montanide ISA-51 Vaccine|HLA-A2-FGF-5	A peptide vaccine comprised of synthetic HLA-A2- and HLA-A3-binding peptides, derived from amino acid sequences of fibroblast growth factor-5 (FGF-5), combined with the adjuvant montanide ISA-51 with potential antineoplastic activity. HLA-A2, A3-restricted FGF-5 peptides contain motifs recognized by the MHC class I molecules HLA-A2 and HLA-A3 and may stimulate a cytotoxic T-cell response against tumor cells that overexpress FGF-5. Montanide ISA-51 (also known as incomplete Freund's adjuvant or IFA), a stabilized water-in-oil emulsion adjuvant containing mineral oil with mannide oleate added as a surfactant, non-specifically stimulates cell-mediated immune responses to antigens.
C48395	Human_Papillomavirus_16_18_L1_Virus-Like_Particle_AS04_Vaccine	Chemotherapy_Regimen	Human Papillomavirus 16/18 L1 Virus-Like Particle/AS04 Vaccine	A recombinant, bivalent, human papillomavirus (HPV) vaccine, containing virus-like particles for HPV types 16 and 18 linked to the adjuvant ASO4, with potential immunoprotective and antineoplastic properties. Upon administration, HPV 16/18 L1 virus-like particle/ASO4 vaccine may generate humoral and cellular immunity against HPV types-16 and -18 antigens, thereby preventing cervical infection upon exposure to HPV types 16 and 18. In addition, this agent may stimulate an antitumoral cellular immune response against cervical cancer associated with HPV infection.
C48396	Human_Prostate-Specific_Membrane_Antigen_DNA_Vaccine	DNA_Vaccine	Human Prostate-Specific Membrane Antigen Plasmid DNA Vaccine|Human PSMA DNA Vaccine	A vaccine consisting of a plasmid DNA encoding the human prostate-specific membrane antigen (PSMA). Upon administration, expressed PSMA may stimulate a cytotoxic T cell response against tumor cells that express this antigen, resulting in tumor cell lysis. (NCI05)
C48397	Iloprost	Chemopreventive_Agent	Iloprost|(E)-(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-((E)-(3S,4RS)-3-hydroxy-4-methyl-1-octen-6-ynyl)-delta(sup 2(1H),delta)-pentalenevaleric Acid|Ciloprost|Iloprost Clathrate|Pentanoic Acid, 5-(hexahydro-5-hydroxy-4-(3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene)-|Ventavis|ZK 36374	A prostacyclin analogue with potential chemopreventive activity. Iloprost binds to the prostacyclin receptor in various target cells, thereby causing vasodilation, inhibition of platelet aggregation, and decreased tumor cell adhesion to endothelium among other effects. Prostacyclin is a naturally occurring eicosanoid with anti-inflammatory, antineoplastic, and anti-metastatic properties. (NCI05)
C48398	Ingenol_3-Angelate	Unclassified_Chemotherapy_Agent	Ingenol 3-Angelate|I3A|PEP005	A selective small-molecule activator of protein kinase C (PKC) isolated from the plant Euphorbia peplus with potential antineoplastic activity. Ingenol 3-angelate (I3A) activates various protein kinase C (PKC) isoforms, thereby inducing apoptosis in some tumor cells, including myeloid leukemia cells, melanoma cells, and basal cell carcinoma cells. The PKC family consists of signaling isoenzymes that regulate many cell processes including proliferation, differentiation, and apoptosis.
C48399	Iodine_I_124_Iododeoxyuridine	Radioconjugate	Iodine I 124 Iododeoxyuridine|I-124 Iododeoxyuridine	A radiopharmaceutical comprised of the thymidine analog, 5-iodo-2-deoxyuridine (idoxuridine), labeled with the positron emitter iodine I 124.  After incorporation into tumor cell DNA, positron emission tomography (PET) is used to image iodine I 124 localized to tumor cells for determining and monitoring tumor burden.
C48400	Iodine_I_131_Monoclonal_Antibody_8H9	Radioimmunoconjugate	Iodine I 131 Monoclonal Antibody 8H9|Iodine I 131 MOAB 8H9	A radioimmunoconjugate consisting of 8H9, a murine IgG1 anti-tenascin monoclonal antibody, radiolabeled with iodine 131 (I 131) with radioimaging and radio-immunotherapeutic properties. Monoclonal antibody 8H9 radiolabeled with I 131 may be used to image and/or destroy tumor cells expressing tenascin. Tenascin is an extracellular matrix protein which is overexpressed in gliomas and other cancers. (NCI05)
C48401	IPI-504	Antineoplastic_Agent	IPI-504	A small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activity. IPI-504 binds to and inhibits the cytosolic chaperone functions of HSP90, which maintains the stability and functional shape of many oncogenic signaling proteins and may be overexpressed or overactive in tumor cells. IPI-504-mediated inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins in susceptible tumor cell populations, which may result in the induction of apoptosis.
C48402	Lestaurtinib	Tyrosine_Kinase_Inhibitor	Lestaurtinib|9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S,10S,12R)-|CEP 701	An orally bioavailable indolocarbazole derivative with antineoplastic properties. Lestaurtinib inhibits autophosphorylation of FMS-like tyrosine kinase 3 (FLT3), resulting in inhibition of FLT3 activity and induction of apoptosis in tumor cells that overexpress FLT3. (NCI05)
C48403	Methylnaltrexone	Opiate_Antagonist	Methylnaltrexone|17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium|N-methylnaltrexone Bromide|Quaternary Ammonium Naltrexone	A methyl derivative of noroxymorphone with selective, opioid-receptor antagonistic activity. Methylnaltrexone displaces opioids from peripheral opioid receptors in the gastrointestinal tract, the bladder, and the skin, resulting in decreases in opioid-related constipation, urinary retention, and pruritis, respectively. Methylnaltrexone does not cross the blood-brain barrier and does not affect the centrally-mediated analgesic effect of opioids.
C48404	MLN518	Tyrosine_Kinase_Inhibitor	MLN518|1-Piperazinecarboxamide, 4-(6-Methoxy-7-(3-(1-piperidinyl)propoxy)-4-quinazolinyl)-N-(4-(1-methylethoxy)phenyl)-|CT53518|Tandutinib	A piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic activity. MLN518 inhibits the autophosphorylation of FLT3 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis.
C48405	Monoclonal_Antibody_CHIR-12_12	Monoclonal_Antibody	Monoclonal Antibody CHIR-12.12	A monoclonal antibody directed against the B-cell surface antigen CD40 with potential antineoplastic activity. Monoclonal antibody CHIR-12.12 binds to and inhibits CD40, thereby inhibiting CD40 ligand-induced cell proliferation and triggering cell lysis via antibody-dependent cellular cytotoxicity (ADCC) in cells overexpressing CD40. CD40, an integral membrane protein found on the surface of B lymphocytes, is a member of the tumor necrosis factor receptor superfamily and is highly expressed in a number of B-cell malignancies.
C48406	Monoclonal_Antibody_hA20	Monoclonal_Antibody	Monoclonal Antibody hA20	A monoclonal antibody directed against the CD20 antigen with potential antineoplastic activity. Monoclonal antibody hA20 (mAb hA20) is a fully humanized antibody that targets the CD20 antigen, a hydrophobic transmembrane protein located on normal pre-B and mature B lymphocytes. Following binding, mAb hA20 triggers a complement-dependent cell lysis and antibody-dependent cell-mediated cytotoxicity in cells overexpressing CD20. (NCI05)
C48407	Monoclonal_Antibody_HuAPF31	Monoclonal_Antibody	Monoclonal Antibody HuAPF31|MOAB HuAFP31	A fully humanized monoclonal antibody directed against alpha fetoprotein with potential antineoplastic activity. Upon administration, monoclonal antibody HuAFP31 (mAb HuAFP31) binds to and stimulates a cytotoxic T lymphocyte (CTL) response against tumor cells that express alpha fetoprotein. (NCI05)
C48408	Monoclonal_Antibody_HuPAM4	Monoclonal_Antibody	Monoclonal Antibody HuPAM4|MOAB HuPAM4	A humanized monoclonal antibody directed against the pancreatic cancer antigen MUC1 with potential antineoplastic activity. Monoclonal antibody HuPAM4 (mAb HuPAM4) binds to cells expressing MUC1 antigen; mAb HuPAM4 may be useful as a carrier for radioisotopes and other antineoplastic therapeutic agents. (NCI05)
C48409	Monoclonal_Antibody_RAV12	Monoclonal_Antibody	Monoclonal Antibody RAV12|anti-RAAG12 MOAB	A chimeric monoclonal antibody directed against a primate-restricted N-linked carbohydrate epitope (glycotope) expressed on various human carcinomas with potential antineoplastic activity. Following binding, monoclonal antibody RAV12 disrupts sodium channels of tumor cells expressing this glycotope, resulting in cell and organelle swelling, loss of membrane integrity, and cell death. (NCI05)
C48410	Mouse_gp100_DNA_Vaccine	DNA_Vaccine	Mouse gp100 Plasmid DNA Vaccine	A vaccine consisting of a plasmid DNA encoding the murine melanoma-associated antigen gp100. Upon administration, expressed gp100 antigen may stimulate a cytotoxic T cell HLA-A2.1-restricted immune response against tumor cells that express the gp100 antigen, resulting in tumor cell lysis. (NCI05)
C48411	Mouse_Prostate-Specific_Membrane_Antigen_DNA_Vaccine	DNA_Vaccine	Mouse Prostate-Specific Membrane Antigen Plasmid DNA Vaccine|Mouse PSMA DNA Vaccine	A vaccine consisting of a plasmid DNA encoding the murine prostate-specific membrane antigen (PSMA). Upon administration, expressed PSMA may stimulate a cytotoxic T cell response against tumor cells that express PSMA, resulting in tumor cell lysis. (NCI05)
C48412	Oncolytic_Adenovirus_Encoding_GM-CSF	Antineoplastic_Vaccine	Oncolytic Adenovirus Encoding GM-CSF|CG0070	A recombinant oncolytic adenovirus encoding the immunohematopoietic cytokine granulocyte-macrophage colony stimulating factor (GM-CSF) with potential antineoplastic activity. Upon administration, the oncolytic adenovirus selectively infects and replicates in tumor cells, which may result in tumor cells lysis. Synergistically, GM-CSF (sargramostim) expressed by the oncolytic adenovirus may promote a cytotoxic T cell response against tumor cells harboring the oncolytic adenovirus, resulting in an immune-mediated tumor cell death.
C48413	Opioid_Growth_Factor	Miscellaneous_Angiogenesis_Inhibitor	Opioid Growth Factor|OGF	An endogenous pentapeptide with potential antineoplastic and antiangiogenic activities. Opioid growth factor (OGF) binds to and activates the OGF receptor, present on some tumor cells and vascular cells, thereby inhibiting tumor cell proliferation and angiogenesis. (NCI05)
C48414	Ovarian_Cancer_Peptide_Vaccine	Antineoplastic_Vaccine	Ovarian Cancer Peptide Vaccine|OC-PEP-VAC	A cancer vaccine comprised of synthetic peptides corresponding to naturally-occurring peptides derived from ovarian cancer cell antigens. Ovarian cancer peptide vaccine may elicit a cytotoxic T-cell response against tumor cells expressing the related ovarian cancer cell antigens. (NCI05)
C48415	Paclitaxel-Loaded_Polymeric_Micelle	Taxane_Compound	Paclitaxel-Loaded Polymeric Micelle	A biodegradable polyethylene glycol-poly(D,L-lactide) copolymer miceller nanoparticle-entrapped formulation of paclitaxel with antineoplastic properties. Paclitaxel promotes microtubule assembly and prevents depolymerization, thus interfering with normal mitosis. The copolymer residue increases the water-solubility of paclitaxel and allows delivery of higher doses than those achievable with paclitaxel alone. (NCI05)
C48416	Picoplatin	Platinum_Compound	Picoplatin|(SP-4-3)-Amminedichloro(2-methylpyridine)platinium|NX-473|ZD0473	A new generation organic platinum analog with an extended spectrum of antineoplastic activity. Designed to overcome platinum drug resistance, picoplatin alkylates DNA, forming both inter- and intra-strand cross-linkages, resulting in inhibition of DNA replication and transcription, and the induction of apoptosis.
C48417	Piperine_Extract_Standardized	Nutritional_Supplement	Piperine Extract (Standardized)|Bioperine|Standardized Piperine Extract	A standardized extract containing the active alkaloid piperine, derived from the fruit of the plant Piper nigrum (black pepper) and/or the plant Piper longum L. (long pepper), with thermogenic properties. Co-ingestion of piperidine enhances the bioavailability of various nutrients, including beta-carotene, curcumin, selenium, pyridoxine and coenzyme Q10. In addition, this agent may exert anti-inflammatory and anti-tumor activities and may enhance the production of serotonin.
C48418	pNGVL4a-Sig_E7_detox_HSP70_DNA_Vaccine	DNA_Vaccine	pNGVL4a-Sig/E7(detox)/HSP70 DNA Vaccine	An antigen-specific DNA cancer vaccine consisting of the coding sequences of a signal peptide (pNGVL4a-Sig), a detox form of the human papillomavirus type 16 (HPV-16) antigen E7, and the heat shock protein 70 (HSP70). Upon administration, this vaccine may generate potent cytotoxic CD8(+) T-cell responses against E7-expressing tumor cells, resulting in tumor cell death.
C48419	Recombinant_Vaccinia-NY-ESO-1_Vaccine	Antineoplastic_Vaccine	Recombinant Vaccinia-NY-ESO-1 Vaccine|rV-NY-ESO-1	A cancer vaccine consisting of a recombinant vaccinia viral vector encoding an immunogenic peptide derived from the cancer-testis antigen NY-ESO-1, an antigen found in normal testis and various tumors, including bladder, breast, hepatocellular, melanoma, and prostate cancers. Vaccination with recombinant vaccinia NY-ESO-1 peptide vaccine may stimulate the host immune system to mount a humoral and cytotoxic T lymphocyte (CTL) response against tumor cells expressing NY-ESO-1 antigen, resulting in tumor cell lysis. (NCI05)
C48420	Sargramostim_Plasmid_DNA_Hepatocellular_Carcinoma_Vaccine_Adjuvant	Antineoplastic_Vaccine	Sargramostim Plasmid DNA Hepatocellular Carcinoma Vaccine Adjuvant|GM-CSF Plasmid DNA Hepatocellular Carcinoma Vaccine	A vaccine adjuvant consisting of a plasmid DNA encoding sargramostim (granulocyte-macrophage colony-stimulating factor). Upon administration, expressed sargramostim may stimulate a cytotoxic T cell response enhancing the host immune response to a concomitantly administered hepatocellular carcinoma vaccine. (NCI05)
C48421	SB-AS15_Adjuvant	Vaccine_Adjuvant	SB-AS15 Adjuvant|SB AS15	A vaccine adjuvant containing CpG 7909, monophosphoryl lipid, and QS-21 with potential antineoplastic and immunostimulatory activities. CpG 7909 is a synthetic 24-mer oligonucleotide containing 3 CpG motifs that selectively targets Toll-like receptor 9 (TLR9), thereby activating dendritic and B cells and stimulating cytotoxic T cell and antibody responses against tumor cells bearing tumor antigens. Monophosphoryl lipid is a detoxified derivative of lipid A, a component of Salmonella minnesota lipopolysaccharide (LPS); this agent may enhance humoral and cellular responses to various antigens. QS-21 is a purified, naturally occurring saponin derived from the South American tree Quillaja saponaria Molina and exhibits various immunostimulatory activities. Combinations of monophosphoryl lipid and QS-21 may be synergistic in inducing humoral and cellular immune responses. (NCI05)
C48422	Synthetic_Peptide-Based_Erythropoiesis_Stimulating_Agent	Immunostimulant	Synthetic Peptide-Based Erythropoiesis Stimulating Agent|Hematide	A synthetic, non-recombinant, pegylated, peptidic erythropoiesis stimulating agent. Synthetic peptide-based erythropoiesis stimulating agent binds to and activates the erythropoietin (EPO) receptor on erythroid progenitor cells, thereby inducing their proliferation and differentiation into mature erythrocytes.
C48423	Tc_94m_Sestamibi	Radioconjugate	Technetium Tc 94m Sestamibi	A radioconjugate consisting of sestamibi labeled with the positron-emitting isotope Tc 94m. Sestamibi is a synthetic molecule of the isonitrile family that diffuses through cell membranes and may preferentially accumulate within mitochondria. Technetium Tc 94m sestamibi may be used in tumor-imaging studies utilizing positron emission tomography (PET). (NCI05)
C48424	TPI_287	Taxane_Compound	TPI 287	A synthetic, third generation taxane with potential antineoplastic activity. TPI 287 binds to tubulin and stabilizes microtubules, resulting in inhibition of microtubule assembly/disassembly dynamics, cell cycle arrest at the G2/M phase, and apoptosis.
C48425	Velafermin	Therapeutic_Fibroblast_Growth_Factor	Velafermin|CG53135|Recombinant FGF-20|Recombinant Human Fibroblast Growth Factor-20	A recombinant human fibroblast growth factor-20 (rhFGF-20) protein with pro-proliferative activity.  Velafermin stimulates DNA synthesis and cell proliferation, specifically promoting epithelial and mesenchymal cell proliferation, and may prevent radiation or chemotherapy-induced oral mucositis.
C48426	Volociximab	Monoclonal_Antibody	Volociximab|anti-a5-beta1 Integrin	A chimeric monoclonal antibody with potential antineoplastic activity. Volociximab binds to and inhibits the activity of alpha(5)beta(1) integrin, thereby inhibiting endothelial cell-cell interactions, endothelial cell-matrix interactions, and angiogenesis. (NCI05)
C48427	XRP9881	Taxane_Compound	XRP9881|RPR 109881A	A semi-synthetic derivative of the taxane 10-deacetylbaccatin III with potential antineoplastic properties. XRP9881 binds to tubulin, promoting microtubule assembly and stabilization and preventing microtubule depolymerization, thereby inhibiting cell proliferation. As it represents poor substrate for P-glycoprotein related drug resistance mechanisms, this agent may be useful for treating multi-drug resistant tumors. XRP9881 penetrates the blood brain barrier. (NCI05)
C48428	Yttrium_Y_90_DOTA_Monoclonal_Antibody_HuAFP31	Radioimmunoconjugate	Yttrium Y 90 DOTA Monoclonal Antibody HuAFP31	A radioimmunoconjugate comprised of the monoclonal antibody HuAFP31, directed against alpha fetoprotein, that is conjugated to the chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and radiolabeled with the beta-emitting radioisotope Yttrium Y90. Yttrium Y 90 DOTA monoclonal antibody HuAFP31 binds to tumor cells expressing alpha fetoprotein, selectively delivering a cytotoxic dose of beta radiation. (NCI05)
C48429	Yttrium_Y_90_DOTA_Monoclonal_Antibody_HuPAM4	Radioimmunoconjugate	Yttrium Y 90 DOTA Monoclonal Antibody HuPAM4	A radioimmunoconjugate comprised of the humanized monoclonal antibody HuPAM4, directed against the pancreatic cancer antigen MUC1, that is conjugated to the chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and radiolabeled with the beta-emitting radioisotope Yttrium Y90. Yttrium Y 90 DOTA monoclonal antibody HuPAM4 binds to tumor cells expressing MUC1 antigen, selectively delivering a cytotoxic dose of beta radiation. (NCI05)
C48430	ZD4054	Endothelin_Receptor_Antagonist	ZD4054	An orally available selective antagonist of the endothelin-A (ET-A) receptor with potential antineoplastic activity. ZD4054 binds selectively to the ET-A receptor, thereby inhibiting endothelin-mediated mechanisms that promote tumor cell proliferation. (NCI05)
C48431	Neural_Crest-Derived_Cell	Neuroectodermal_Cell|Neuroendocrine_Cell	Neural Crest-Derived Cell
C48432	Kilovolt_Peak	Conceptual_Entities	Kilovolt Peak|kVp	The peak accelerating voltage applied in an X-ray tube between the cathode and anode.
C48433	Tilt	Characteristics	Tilt	The degree of deviation from a vertical plane.
C48434	Electrical_Current	Physical_Phenomena_or_Properties	Electrical Current|Current	The movement of electrical charges in a conductor.
C48435	X-Ray_Tube	Diagnostic_Therapeutic_and_Research_Equipment	X-Ray Tube	A vacuum tube containing a metal target onto which a beam of electrons is directed at high energy for the generation of X rays.
C48436	Kilo	General_Modifier	Kilo|kilo-	A prefix indicating a quantity of one thousand.
C48437	Milli	General_Modifier	Milli|milli-	A prefix indicating a quantity of one one-thousandth.
C48438	Micro	General_Modifier	Micro|micro-	A prefix indicating a quantity of one one-millionth.
C48439	Revolution	Characteristics	Revolution|Rotation	A single complete turn (axial or orbital).
C48440	Single	General_Modifier	Single|Solitary	Not accompanied by another or others.
C48441	Table	Diagnostic_Therapeutic_and_Research_Equipment	Table	A piece of furniture having a smooth flat top that is usually supported by one or more vertical legs or any object of a similar appearance.
C48442	Pitch	Characteristics	Pitch	The degree of deviation from a horizontal plane.
C48443	Standard_Operating_Procedure	Means	Standard Operating Procedure|SOP	An established procedure to be followed in carrying out a given operation or in a given situation.
C48444	Synchronization	Conceptual_Entities	Synchronization	An adjustment that causes something to occur or recur in unison.
C48445	Storage_Medium	Media	Storage Medium|Storage Media	Any media or device used for storing data.
C48447	Adrenal_Cortex_Oncocytic_Adenoma	Adrenal_Cortex_Adenoma|Oxyphilic_Adenoma	Adrenal Cortex Oncocytic Adenoma	A usually non-functioning variant of adrenal cortex adenoma, composed of large cells with abundant granular eosinophilic cytoplasm. (NCI05)
C48448	Neoplastic_Adrenal_Cortex_Oncocyte	Neoplastic_Adrenal_Cortical_Cell|Neoplastic_Oncocyte	Neoplastic Adrenal Cortical Oncocyte|Neoplastic Adrenal Cortex Oncocyte
C48449	Cortisol_Producing_Adrenal_Cortex_Adenoma	Adrenal_Cortex_Adenoma	Cortisol Producing Adrenal Cortex Adenoma|Cortisol Producing Adrenal Cortical Adenoma	An adenoma of the adrenal cortex that produces cortisol.  It may be associated with Cushing's syndrome.  Clinical presentation includes weight gain, round face, easy bruising, muscle weakness, emotional changes, hirsutism, and hypertension.  (NCI05)
C48450	Unit_of_Acceleration	Unit_by_Category	Unit of Acceleration|Acceleration Unit	A unit of the rate of change of linear or angular velocity with respect to time.
C48451	Aldosterone_Producing_Adrenal_Cortex_Adenoma	Adrenal_Cortex_Adenoma	Aldosterone Producing Adrenal Cortex Adenoma|Aldosterone Producing Adrenal Cortical Adenoma	An adenoma of the adrenal cortex that produces aldosterone.  It may be associated with Conn syndrome.  Clinical presentation includes hypertension, hypokalemia, and muscle weakness .  (NCI05)
C48452	Sex_Hormone_Producing_Adrenal_Cortex_Adenoma	Adrenal_Cortex_Adenoma	Sex Hormone Producing Adrenal Cortex Adenoma|Sex Hormone Producing Adrenal Cortical Adenoma	A rare adenoma of the adrenal cortex that produces androgens or estrogens. (NCI05)
C48453	Unit_of_Amount_of_Substance	Unit_by_Category	Unit of Amount of Substance|Amount of Substance Unit	Physical quantity that measures the number of elementary entities in the object compared with the number of elementary entities (atoms, molecules, ions, electrons, or particles) in 0.012 kilogram of pure carbon-12.
C48454	Androgen_Producing_Adrenal_Cortex_Adenoma	Sex_Hormone_Producing_Adrenal_Cortex_Adenoma	Androgen Producing Adrenal Cortex Adenoma|Androgen Producing Adrenal Cortical Adenoma	A rare adenoma of the adrenal cortex that produces androgens.  Female patients usually have symptoms related to virilism. (NCI05)
C48455	Unit_of_Angle_Measurement	Unit_by_Category	Unit of Angle Measurement|Unit of Angle	A unit of measurement of a plane or solid angle.
C48456	Estrogen_Producing_Adrenal_Cortex_Adenoma	Sex_Hormone_Producing_Adrenal_Cortex_Adenoma	Estrogen Producing Adrenal Cortex Adenoma|Estrogen Producing Adrenal Cortical Adenoma	A rare adenoma of the adrenal cortex that produces estrogens.  Male patients may develop gynecomastia and impotence. (NCI05)
C48457	Unit_of_Plane_Angle_Measurement	Unit_of_Angle_Measurement	Unit of Plane Angle Measurement|Plane Angle Unit	A unit of measurement of the interval or space between the intersecting lines.
C48458	Non-Functioning_Adrenal_Cortex_Adenoma	Adrenal_Cortex_Adenoma	Non-Functioning Adrenal Cortex Adenoma|Adrenal Cortical Incidentaloma|Non-Functioning Adrenal Cortical Adenoma	An adenoma of the adrenal cortex characterized by the absence of a hormonal syndrome or symptoms suggestive of adrenal disease. (NCI05)
C48459	Unit_of_Solid_Angle_Measurement	Unit_of_Angle_Measurement	Unit of Solid Angle Measurement|Solid Angle Unit	A unit of ratio of the spherical area to the square of the radius. The spherical area is a rectilinear projection of the object of any shape onto a plane normal to the unit vector, and the solid angle is the surface area of that projection.
C48460	Square_Centimeter	Unit_of_Area|Unit_of_Potency	Square Centimeter|SQ CM|SQUARE CENTIMETER|Square Centimetre|cm2|sq. cm	A CGS unit of area measurement equal to a square measuring one centimeter on each side. One square centimeter is equal to 10E-4 square meter.
C48461	Square_Foot	Unit_of_Area|Unit_of_Potency	Square Foot|FEET, SQUARE|SQ FT|sq. ft.	A traditional unit of area equal to 144 square inches, 929.0304 square centimeters, or 9.290304E-2 square meters.
C48462	Square_Yard	Unit_of_Area|Unit_of_Potency	Square Yard|SQ YD|SQUARE YARD	A traditional unit of area equal to 9 square feet, 1296 square inches, or 0.836 127 36 square meter.
C48463	Biological_Unit	Unit_by_Category	Biological Unit|Unit of Biological Measurement
C48464	Carotid_Sinus_Rhythm_Unit	Biological_Unit|Unit_of_Potency	Carotid Sinus Rhythm Unit|CAROTID SINUS RHYTHM UNITS|CSRU
C48465	Fowlpox-NY-ESO-1_Vaccine	Fowlpox_Virus_Vaccine	Fowlpox-NY-ESO-1 Vaccine|rF-NY-ESO-1	A cancer vaccine consisting of a recombinant fowlpox virus vector encoding an immunogenic peptide derived from the cancer-testis antigen NY-ESO-1, an antigen found in normal testis and various tumors, including bladder, breast, hepatocellular, melanoma, and prostate cancers. Vaccination with NY-ESO-1 peptide vaccine may stimulate the host immune system to mount a humoral and cytotoxic T lymphocyte (CTL) response against tumor cells expressing NY-ESO-1 antigen, resulting in tumor cell lysis. (NCI05)
C48466	Curie	Unit_of_Potency|Unit_of_Radioactivity	Curie|CI|CURIE	A unit of radioactivity in the CGS system, defined as 3.7 E10 atomic disintegrations or other nuclear transformations per second. One curie is equal to 37 gigabecquerels.
C48467	Unit_of_Radioactivity	Unit_of_Radiation	Unit of Radioactivity
C48468	Unit_of_Radiation	Unit_by_Category	Unit of Radiation
C48469	United_States_Pharmacopoeia_Unit	Unit_of_Potency	United States Pharmacopeia Unit|UNITED STATES PHARMACOPEIA|USP|United States Pharmacopoeia Unit	An arbitrary unit used in the United States Pharmacopeia to express the biologic activity of antibiotics, endocrine preparations, sera, toxins, vaccines, and related products, corresponding to units established internationally, by the FDA, or by the NIH.
C48470	Unit_of_Potency	Unit_by_Category	Potency Unit|POTENCY UNIT|Unit of Potency
C48471	Publication	Document_Type	Publication	A copy of a printed work offered for distribution.
C48472	Adjust_pH_Dosing_Unit	Unit_of_Potency	Adjust pH Dosing Unit|ADJ PH|ADJUST PH
C48473	Ampule_Dosing_Unit	Unit_of_Potency	Ampule Dosing Unit|AMPULE
C48474	Bag_Dosing_Unit	Unit_of_Potency	Bag Dosing Unit|BAG
C48475	Bar_Dosing_Unit	Unit_of_Potency	Bar Dosing Unit|BAR
C48476	Bolus_Dosing_Unit	Unit_of_Potency	Bolus Dosing Unit|BOL|BOLUS
C48477	Bottle_Dosing_Unit	Unit_of_Potency	Bottle Dosing Unit|BOT|BOTTLE
C48478	Box_Dosing_Unit	Unit_of_Potency	Box Dosing Unit|BOX
C48479	Can_Dosing_Unit	Unit_of_Potency	Can Dosing Unit|CAN
C48480	Capsule_Dosing_Unit	Unit_of_Potency	Capsule Dosing Unit|CAP|CAPSULE
C48481	Cartridge_Dosing_Unit	Unit_of_Potency	Cartridge Dosing Unit|CARTRIDGE|CTG
C48482	Clinical_Unit	Unit_of_Potency	Clinical Unit|CLINICAL UNITS|CU
C48483	Coat_Dosing_Unit	Unit_of_Potency	Coat Dosing Unit|COAT
C48484	Container_Dosing_Unit	Unit_of_Potency	Container Dosing Unit|CONTAINER|CTR
C48485	Count_Dosing_Unit	Unit_of_Potency	Count Dosing Unit|CNT|COUNT
C48487	Cubic_Foot	Unit_of_Potency|Unit_of_Volume	Cubic Foot|CU FT|FEET, CUBIC|cu. ft.|ft.3	A traditional unit of volume equal to 1728 cubic inches, or 1/27 cubic yard, or 0.028 316 85 cubic meter (28.316 85 liters). The cubic foot holds about 7.4805 US gallons.
C48488	Cubic_Inch	Unit_of_Potency|Unit_of_Volume	Cubic Inch|CU IN|CUBIC INCH	A traditional unit of volume equal to 16.3871 cubic centimeters, or 0.5541 US fluid ounce.
C48489	Cylinder_Dosing_Unit	Unit_of_Potency	Cylinder Dosing Unit|CYL|CYLINDER
C48490	Disk_Dosing_Unit	Unit_of_Potency	Disk Dosing Unit|DISK
C48491	Drop_Dosing_Unit	Unit_of_Potency|Unit_of_Volume	Drop|DROPS|Drop Unit|gt|gtt	A unit of volume used in pharmacy and equal to 0.05 milliliter (20 drops/ml).
C48492	Drum_Dosing_Unit	Unit_of_Potency	Drum Dosing Unit|DRUM
C48493	Fluid_Dram	Unit_of_Potency|Unit_of_Volume	Fluid Dram US|FL DR|FLUID DRAM	A unit of volume equal to 1/8 fluid ounce, 0.225 586 cubic inch or 3.696 691 milliliters.
C48494	Fluid_Ounce	Unit_of_Potency|Unit_of_Volume	Fluid Ounce US|FL OZ|FLUID OUNCE	A traditional unit of liquid volume equal in the US customary system to 1/16 pint, or 1.804 687 cubic inches or 29.573 531 milliliters.
C48495	Gallon	Unit_of_Volume	Gallon	A traditional unit of volume used for measuring liquids and dry matter. Gallons of various sizes (predominantly in the range of 3.5 - 4.75 liters) have been used in different countries since Roman times.
C48496	Generator_Dosing_Unit	Unit_of_Potency	Generator Dosing Unit|GEN|GENERATOR
C48497	Grain	Unit_of_Mass|Unit_of_Potency	Grain|GR|GRAIN	A traditional unit of mass derived from the weight of a grain and equal to one seven-thousandth of a pound, or 1/480 troy ounce, or 64.79891 milligrams. The original English grain unit based on the mass of a ripe grain barleycorn was larger the corresponding grain units of France and other European nations which were based on the weight of the smaller wheat grain.
C48498	Homeopathic_Dilution_Unit	Unit_of_Potency	Homeopathic Dilution Unit|HOMEOPATHIC DILUTION|X
C48499	Implant_Dosing_Unit	Unit_of_Potency	Implant Dosing Unit|IMP|IMPLANT
C48500	Inch	Unit_of_Length|Unit_of_Potency	Inch|IN|INCH	A traditional unit of length equal to 2.54 centimeters.
C48501	Inhalation_Dosing_Unit	Unit_of_Potency	Inhalation Dosing Unit|INH|INHALATION
C48502	Jar_Dosing_Unit	Unit_of_Potency	Jar Dosing Unit|JAR
C48503	Kallikrein_Inhibitor_Unit	Biological_Unit|Unit_of_Potency	Kallikrein Inhibitor Unit|KALLIKREIN INHIBITOR UNIT|KIU
C48504	Kit_Dosing_Unit	Unit_of_Potency	Kit Dosing Unit|KIT
C48505	Liter	Unit_of_Potency|Unit_of_Volume	Liter|L|LITER
C48506	Lozenge_Dosing_Unit	Unit_of_Potency	Lozenge Dosing Unit|LOZ|LOZENGE
C48507	Microcurie	Unit_of_Potency|Unit_of_Radioactivity	Microcurie|MICROCURIE|UCI	A unit of radioactivity equal to one millionth of curie or 37 kilobecquerels, and corresponding to a radioactivity of 37 000 atomic disintegrations per second.
C48508	Micromolar	Unit_of_Concentration|Unit_of_Potency	Micromolar|MICROMOLAR|UMOLAR
C48509	Micromole	Unit_of_Amount_of_Substance|Unit_of_Potency	Micromole|MICROMOLE|UMOLE	A unit of amount of substance equal to a millionth of a mole.
C48510	Micron	Unit_of_Length|Unit_of_Potency	Micron|MCN|MICRON|Micrometer	A unit of length in metric system equal to 10E-6 meter, or micrometer.
C48511	Millicurie	Unit_of_Potency|Unit_of_Radioactivity	Millicurie|MCI|MILLICURIE	A unit of radioactivity equal to one thousandth of curie or 37 megabecquerels, and corresponding to a radioactivity of 37 millions of atomic disintegrations per second.
C48512	Milliequivalent	Unit_of_Equivalent_Weight|Unit_of_Potency	Milliequivalent|MEQ|MILLIEQUIVALENT	A unit of relative amount of a substance equal to one thousandth of an equivalent weight.
C48513	Millimole	Unit_of_Amount_of_Substance|Unit_of_Potency	Millimole|MILLIMOLE|MMOLE	A unit of amount of substance equal to 0.001 mole.
C48514	Minim	Unit_of_Potency|Unit_of_Volume	Minim|MINIM|Min	A traditional unit of volume used in pharmacy for small quantities of liquids. The US minim is equal to 0.003 760 cubic inch or 61.610 microliters.
C48516	Nanogram	Unit_of_Mass|Unit_of_Potency	Nanogram|NANOGRAM|NGM	A metric unit of mass equal to 10E-9 gram, or one millionth of a milligram.
C48517	Nanomole	Unit_of_Amount_of_Substance|Unit_of_Potency	Nanomole|NANOMOLE|NMOLE	A unit of amount of substance equal to 10E-9 mole.
C48519	Ounce	Unit_of_Mass|Unit_of_Potency	Ounce|OUNCE|OZ	A traditional unit of mass. The avoirdupois ounce is equal to 1/16 pound, or 28.3495 grams, or 0.911 457 troy ounce.
C48520	Package_Dosing_Unit	Unit_of_Potency	Package Dosing Unit|PACKAGE|PKG
C48521	Packet_Dosing_Unit	Unit_of_Potency	Packet Dosing Unit|PACKET|PKT
C48522	Part_Dosing_Unit	Unit_of_Fraction|Unit_of_Potency	Part Dosing Unit|PARTS
C48523	Part_Per_Million	Part_Dosing_Unit	Part Per Million|PART PER MILLION|PPM
C48524	Patch_Dosing_Unit	Unit_of_Potency	Patch Dosing Unit|PATCH
C48525	Pellet_Dosing_Unit	Unit_of_Potency	Pellet Dosing Unit|PEL|PELLET
C48527	Percent_Weight_Volume	Percent_Unit|Unit_of_Potency	Percent Weight per Volume|%W/V|PERCENT WEIGHT/VOLUME|Percent Weight/Volume
C48528	Percent_Weight_Weight	Percent_Unit|Unit_of_Potency	Percent Weight per Weight|%W/W|PERCENT WEIGHT/WEIGHT|Percent Weight/Weight
C48529	Pint	Unit_of_Potency|Unit_of_Volume	Pint|PINT|PT
C48530	Pouch_Dosing_Unit	Unit_of_Potency	Pouch Dosing Unit|POUCH
C48531	Pound	Unit_of_Mass|Unit_of_Potency	Pound|LB|POUND	A traditional unit of mass. By international agreement, one avoirdupois pound is equal to exactly 0.453 592 37 kilogram, 16 ounces, or 1.215 28 troy pounds.
C48532	Pressor_Unit	Biological_Unit|Unit_of_Potency	Pressor Unit|PRESSOR UNITS|PRU
C48533	Protein_Unit	Biological_Unit|Unit_of_Potency	Protein Unit|PNU|PROTEIN UNIT
C48534	Quart	Unit_of_Potency|Unit_of_Volume	Quart|QT|QUART
C48535	Saturated_Dosing_Unit	Unit_of_Potency	Saturated Dosing Unit|SAT|SATURATED
C48536	Scoopful_Dosing_Unit	Unit_of_Potency|Unit_of_Volume	Scoopful Dosing Unit|SCOOPFUL|SCP
C48537	Spray_Dosing_Unit	Unit_of_Potency	Spray Dosing Unit|SPRAY
C48538	Strip_Dosing_Unit	Unit_of_Potency	Strip Dosing Unit|STRIP
C48539	Suppository_Dosing_Unit	Unit_of_Potency	Suppository Dosing Unit|SUPP|SUPPOSITORY
C48540	Syringe_Dosing_Unit	Unit_of_Potency	Syringe Dosing Unit|SYR|SYRINGE
C48541	Tablespoon_Dosing_Unit	Unit_of_Potency|Unit_of_Volume	Tablespoon Dosing Unit|TABLESPOON|TBSP|Tablespoon Unit|Tablespoonful|Tblsp|Tbsp|Tsp	A unit of volume informally used in pharmacy. Under the metric system the tablespoon has been standardized at 15 milliliters in US, Britain, Canada, and New Zealand, and at 20 milliliters in Australia and some European countries.
C48542	Tablet_Dosing_Unit	Unit_of_Potency	Tablet Dosing Unit|TAB|TABLET
C48543	Tampon_Dosing_Unit	Unit_of_Potency	Tampon Dosing Unit|TAMP|TAMPON
C48544	Teaspoon_Dosing_Unit	Unit_of_Potency|Unit_of_Volume	Teaspoon Dosing Unit|TEASPOON|TSP|Teaspoon Unit|tsp	A unit of volume used in pharmacy equal to 5 milliliters.
C48545	Test_Dosing_Unit	Unit_of_Potency	Test Dosing Unit|TEST
C48546	Ton	Unit_of_Mass|Unit_of_Potency	Ton|TON|Tonne	A metric unit of mass equal to 1000 kilograms, or 2204.623 pounds avoirdupois.
C48547	Trace_Dosing_Unit	Unit_of_Potency	Trace Dosing Unit|TRACE
C48548	Troche_Dosing_Unit	Unit_of_Potency	Troche Dosing Unit|TRO|TROCHE
C48549	Tube_Dosing_Unit	Unit_of_Potency	Tube Dosing Unit|TUBE
C48551	Vial_Dosing_Unit	Unit_of_Potency	Vial Dosing Unit|VIAL
C48552	Wafer_Dosing_Unit	Unit_of_Potency	Wafer Dosing Unit|WAFER
C48553	Yard	Unit_of_Length|Unit_of_Potency	Yard|YARD|YD	A traditional unit of length equal to 3 feet, or 36 inches, or 0.9144 meter.
C48554	Normality-Based_Dosing_Unit	Unit_of_Concentration|Unit_of_Potency	Normality-Based Dosing Unit|N|NORMAL
C48555	Molarity-Based_Dosing_Unit	Unit_of_Concentration|Unit_of_Potency	Molarity-Based Dosing Unit|MOLAR
C48556	Structured_Product_Labeling_Color	Properties_or_Attributes	Structured Product Labeling Color|SPL COLOR
C48557	Structured_Product_Labeling_Shape	Properties_or_Attributes	Structured Product Labeling Shape|SPL SHAPE
C48558	No_Evidence_of_Metastatic_Disease	Clinical_Course_of_Disease	No Evidence of Metastatic Disease
C48559	Neoplastic_Chromaffin_Cell	Neoplastic_Neuroendocrine_Cell	Neoplastic Chromaffin Cell
C48560	Malignant_Chromaffin_Cell	Malignant_Neuroendocrine_Cell|Neoplastic_Chromaffin_Cell	Malignant Chromaffin Cell
C48562	Unit_of_Velocity	Unit_by_Category	Unit of Velocity|Velocity Unit
C48563	Unit_of_Wave_Number	Unit_by_Category	Unit of Wave Number
C48564	Unit_of_Linear_Velocity	Unit_of_Velocity	Unit of Linear Velocity
C48565	Unit_of_Angular_Velocity	Unit_of_Velocity	Unit of Angular Velocity
C48566	Unit_of_Mass_Fraction	Unit_of_Fraction	Unit of Mass Fraction
C48567	Unit_of_Flow_Rate	Unit_by_Category	Unit of Flow Rate
C48568	Unit_of_Volumetric_Flow_Rate	Unit_of_Flow_Rate	Unit of Volumetric Flow Rate
C48569	Unit_of_Mass_Flow_Rate	Unit_of_Flow_Rate	Unit of Mass Flow Rate
C48570	Percent_Unit	Unit_of_Fraction|Unit_of_Potency	Percent Unit|%|PERCENT|Unit of Percent
C48571	Percent_Volume_per_Volume	Percent_Unit|Unit_of_Potency	Percent Volume per Volume|%V/V|PERCENT VOLUME/VOLUME|Percent Volume/Volume
C48572	Miscellaneous_Unit	Unit_by_Category	Miscellaneous Unit
C48573	Expiration	Conceptual_Entities	Amplification|Expiration|Expire|Expired	To come to a close or end of useable period; termination.
C48574	Unit_of_Fraction	Unit_by_Category	Unit of Fraction
C48576	Extra-Adrenal_Sympathetic_Paraganglioma	Extra-Adrenal_Paraganglioma|Sympathetic_Paraganglioma	Extra-Adrenal Sympathetic Paraganglioma|Extra-Adrenal Chromaffin Neoplasm|Extra-Adrenal Chromaffinoma|Extra-Adrenal Pheochromocytoma|Extra-Adrenal Sympathetic Paraganglionic Neoplasm|Extraadrenal Pheochromocytoma	A benign or malignant sympathetic paraganglioma arising from paraganglia outside the adrenal gland.  Clinical symptoms are related to secretion of catecholamines.  Representative examples include the superior and inferior paraaortic and bladder paragangliomas.
C48577	Fluid_Ounce_British	Unit_of_Volume	Fluid Ounce British	A traditional unit of liquid volume equal in the British Imperial system to 1/20 pint, or 1.733 871 cubic inches or 28.413 063 milliliters.
C48578	Miscellaneous_Potency_Unit	Unit_of_Potency	Miscellaneous Potency Unit|MISC|MISCELLANEOUS
C48579	International_Unit_of_Biological_Activity	Biological_Unit|Unit_of_Potency	International Unit|INTERNATIONAL UNITS|IU	The unitage assigned by the WHO to International biological Standards - substances, classed as biological according to the criteria provided by WHO Expert Committee on Biological Standardization (e.g. hormones, enzymes, and vaccines), to enable the results of biological and immunological assay procedures to be expressed in the same way throughout the world. The definition of an international unit is generally arbitrary and technical, and has to be officially approved by the International Conference for Unification of Formulae.
C48580	Gallon_US	Gallon|Unit_of_Potency	Gallon US|GAL|GALLON|Liquid Gallon US|Queen Annes Wine Gallon	The US unit of liquid volume legally defined as 3785.411784 milliliters (3.785 411 784 liters), or 231 cubic inches. The US gallon holds 4 liquid quarts; the gallon of water gallon weighs approximately 8.33 pounds.
C48581	Gallon_Scotland	Gallon	Gallon Scotland|Gallon Scots	A traditional unit of volume equal to 4 Scots quarts, or approximately three British Imperial gallons, or 3.6 US liquid gallons, or 13.63 liters.
C48582	Gallon_British	Gallon	Gallon British|Imperial Gallon	A traditional unit of volume designed to contain 10 pounds of distilled water under precisely defined conditions and equal to 4.546 091 liters, 277.4194 cubic inches, or 1.20095 US liquid gallons, or 1.03206 US dry gallons.
C48583	Gallon_Historical	Gallon	Gallon Historical|Corn Gallon British|Dry Gallon US|Grain Gallon British|Winchester Corn Gallon	A historical British unit of dry volume equal to 4 dry quarts, or 1/8 of a US bushel (Winchester bushel), or 268.8025 cubic inches, or 4404.88377086 milliliters.
C48584	Paraaortic_Region	Body_Region	Paraaortic Region
C48585	Unit_of_Equivalent_Weight	Unit_by_Category	Unit of Equivalent Weight	A unit of relative amount of a substance that combines with or displaces 8.0 grams of oxygen or 1.008 gram of hydrogen. The unit is usually expressed in grams and is equal to the amount of substance that gains or loses one mole of electrons in a redox reaction, or to the amount of substances that releases or accepts one mole of hydrogen ions in a neutralization reaction; or to the amount of electrolyte that carries one mole of positive or negative charge. This is a large unit and measurements are more often done in its derivatives, e.g. in milliequivalents.
C48586	Slow_Growing_Painless_Mass	Slow_Growing_Mass	Slow Growing Painless Mass
C48587	Potency_Not_Applicable	Unit_of_Potency	Potency Not Applicable|N/A|NOT APPLICABLE
C48588	Potency_Not_Given	Unit_of_Potency	Potency Not Given|PNG|POTENCY NOT GIVEN
C48589	Base_of_the_Heart	Heart_Part	Base of the Heart
C48590	Quantity_Sufficient	Unit_of_Potency	Quantity Sufficient|QS|QUANTITY SUFFICIENT
C48591	Potency_Unassigned	Unit_of_Potency	Potency Unassigned|U/A|UNASSIGNED
C48592	Gastrointestinal_Hemorrhage	Gastrointestinal_System_Signs_and_Symptoms|Hemorrhage	Gastrointestinal Hemorrhage
C48593	Neoplastic_Epithelioid_Neuroendocrine_Cell	Neoplastic_Neuroendocrine_Cell	Neoplastic Epithelioid Neuroendocrine Cell
C48594	Neoplastic_Schwann-Like_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Neoplastic Schwann-Like Cell
C48595	Ganglion_Cell-Like_Elements_Present	Morphologic_Finding	Ganglion Cell-Like Elements Present
C48596	Invasive_Prostate_Carcinoma	Prostate_Carcinoma	Invasive Prostate Carcinoma|Infiltrating Prostate Carcinoma
C48598	Satellite_Nodule	Nodule	Satellite Nodule
C48599	Matted_Lymph_Nodes_Present	Lymph_Node_Involvement	Matted Lymph Nodes
C48600	Re-Excision	Excision	Re-Excision
C48601	Enucleation	Excision	Enucleation
C48602	Total_Gleason_Score_for_Prostate_Cancer	Gleason_Score_for_Prostate_Cancer	Total Gleason Score for Prostate Cancer|Total Gleason Score
C48603	Primary_Gleason_Score_for_Prostate_Cancer	Gleason_Score_for_Prostate_Cancer	Primary Gleason Score for Prostate Cancer|Primary Gleason Score
C48604	Secondary_Gleason_Score_for_Prostate_Cancer	Gleason_Score_for_Prostate_Cancer	Secondary Gleason Score for Prostate Cancer|Secondary Gleason Score
C48605	Tertiary_Gleason_Score_for_Prostate_Cancer	Gleason_Score_for_Prostate_Cancer	Tertiary Gleason Score for Prostate Cancer|Tertiary Gleason Score
C48606	Focal_Pattern	Morphologic_Architectural_Pattern	Focal Pattern
C48607	Invasive_Melanoma	Melanoma	Invasive Melanoma|Infiltrating Melanoma
C48608	Wide_Skin_Excision	Excision	Wide Skin Excision
C48611	Elliptical_Skin_Excision	Excision	Elliptical Skin Excision
C48612	Minimal_Deviation_Melanoma	Cutaneous_Melanoma	Minimal Deviation Melanoma
C48613	Melanoma_in_Congenital_Melanocytic_Nevus	Cutaneous_Melanoma	Melanoma in Congenital Melanocytic Nevus
C48614	Neurotropic_Melanoma	Melanoma	Neurotropic Melanoma
C48615	Lesion_by_Focality	Lesion	Lesion by Focality
C48616	Unifocal_Lesion	Lesion_by_Focality	Unifocal Lesion
C48617	One_or_More_Mitotic_Figure_per_cubic_mm_Present	Retired_Concepts	One or More Mitotic Figure per cubic mm Present
C48618	Less_Than_1_Mitotic_Figure_per_cubic_mm_Present	Retired_Concepts	Less Than 1 Mitotic Figure per cubic mm Present
C48619	Incidental_Finding	Other_Finding	Incidental Finding
C48620	Positive_Surgical_Margin	Positive_Test_Result	Positive Surgical Margin
C48621	Negative_Surgical_Margin	Negative_Test_Result	Negative Surgical Margin
C48622	Mucosal_Lentiginous_Melanoma	Acral_Lentiginous_Malignant_Melanoma	Mucosal Lentiginous Melanoma|Mucosal Lentiginous Malignant Melanoma
C48623	Route_of_Administration_Not_Applicable	Drug_Route_of_Administration	Route of Administration Not Applicable|NA|NOT APPLICABLE	Routes of administration are not applicable.
C48624	Dosage_Form_Not_Applicable	Pharmaceutical_Dosage_Form	Dosage Form Not Applicable|NOT APPLICABLE	The use of a dosage form term is not relevant or appropriate.
C48625	Neoplastic_Parathyroid_Gland_Water-Clear_Cell	Neoplastic_Parathyroid_Gland_Clear_Cell	Neoplastic Parathyroid Gland Water-Clear Cell
C48626	Package_Type_Not_Stated	Drug_Packaging_Device	Package Type Not Stated|NOT STATED|NS	The package type is not stated or is unavailable.
C48627	McCune-Albright_Syndrome	Endocrine_Syndrome	McCune-Albright Syndrome|MAS
C48628	Sexual_Precocity	Endocrine_System_Finding	Sexual Precocity
C48629	CYP2A6_Gene	Cytochrome_P450_Family_Gene	CYP2A6 Gene|CYP2A6|Cytochrome P450, Family 2, Subfamily A, Polypeptide 6 Gene	Human CYP2A6 gene (cytochrome P450 family 2, subfamily A), located at 19q13.2, encodes the cytochrome P450 2A6 protein, a monooxygenase enzyme that exhibits coumarin 7-hydroxylase activity and is the major nicotine C-oxidase. Certain alleles of this gene contribute to the poor metabolizer phenotype, which is characterized by the inability to use cytochrome P450-dependent metabolic pathways for drug elimination. The wild-type CYP2A6 gene is both a determinant of smoking behavior and a susceptibility factor for lung cancer. Methoxsalen, an inhibitor of cytochrome P450 2A6, blocks metabolism of nicotine, thereby slowing conversion of this drug into its cancer-causing metabolites.
C48630	Tyrosinase_146-156_Peptide	Tyrosinase_Peptide	Tyrosinase:146-156 Peptide	A synthetic peptide consisting of amino acid residues 146 through 156 of the enzyme tyrosinase, a protein frequently expressed by melanoma cells, with antitumor activity. Vaccination with tyrosinase:146-156 peptide may stimulate cytotoxic T lymphocyte response against tyrosinase-expressing tumor cells, resulting in decreased tumor growth and cell lysis.
C48631	gp100_614-622_Peptide	Vaccine_Antigen	gp100:614-622 Peptide	A synthetic peptide consisting of amino acid residues 614 through 622 of the melanoma-melanocyte antigen glycoprotein 100 (gp100). Vaccination with gp100:614-622 peptide may stimulate a cytotoxic T-cell immune response against tumor cells that express this antigen, resulting in decreased tumor growth and cell lysis. gp100 antigen is a self-antigen expressed by melanocytes, pigmented retinal cells and most melanoma lesions and recognized via class I and II HLA-restricted mechanisms.
C48632	HLA-A1-Restricted_MAGE-3_Peptide	Vaccine_Antigen	HLA-A1-Restricted MAGE-3 Peptide	A peptide comprised of the synthetic human leukocyte antigen (HLA)-A1-binding peptides derived from amino acid sequences of MAGE-3 with potential antitumor activity. Vaccination with HLA-A1-restricted MAGE-3 peptide may elicit a cytotoxic T lymphocyte immune response against tumor cells expressing MAGE-3. MAGE-3 is an antigen found on many tumor cell types, including melanoma and lung, prostate, colon, thyroid, and breast cancers.
C48633	HLA-B44-Restricted_MAGE-3_Peptide	Vaccine_Antigen	HLA-B44-Restricted MAGE-3 Peptide	A peptide comprised of the synthetic human leukocyte antigen (HLA)-B44-binding peptides derived from amino acid sequences of MAGE-3 with potential antitumor activity. Vaccination with HLA-B44-restricted MAGE-3 peptide may elicit a cytotoxic T lymphocyte immune response against tumor cells expressing MAGE-3. MAGE-3 is an antigen found on many tumor cell types, including melanoma and lung, prostate, colon, thyroid, and breast cancers.
C48634	HLA-B44-Restricted_Tyrosinase_Peptide	Tyrosinase_Peptide	HLA-B44-Restricted Tyrosinase Peptide	A synthetic peptide consisting of synthetic human leukocyte antigen (HLA)-B44-binding peptides derived from amino acid sequences of the melanoma-associated enzyme tyrosinase with potential antitumor activity. Vaccination with HLA-B44-restricted tyrosinase peptide may stimulate cytotoxic T lymphocyte response against tyrosinase-expressing tumor cells, resulting in decreased tumor growth and cell lysis.
C48635	MSCV_MGMTP140K_Retroviral_Vector-Transduced_CD34_Autologous_PBSC	Viral_Vector-Gene_Complex	MSCV (MGMTP140K) Retroviral Vector-Transduced CD34+ Autologous PBSC	A murine stem cell virus (MSCV) retroviral vector expressing a mutant version (MGMTP140K) of the human DNA repair protein O6-alkylguanine-DNA methyltransferase (MGMT). MGMTP140K is specifically resistant to the inhibitor O6-benzylguanine compared to the wild type. Transduction of CD34+ autologous peripheral blood stem cells (PBSC) by this retroviral vector results in an integration and transgene expression of MGMT in CD34+ cells. MSCV (MGMTP140K) retroviral vector can be used in combination with O6-alkylating drugs to protect the hematopoietic system against the hematopoietic toxicity of these chemotherapeutic agents.
C48636	E7080	Tyrosine_Kinase_Inhibitor	E7080
C48637	_851B_gel	Human_Papilloma_Virus_Vaccine	851B_Gel|851B Gel
C48638	Recombinant_Vaccinia-Multiepitope_Melanoma_Peptides-B7_1-B7_2_Vaccine	Vaccinia_Vaccine	Recombinant Vaccinia-Multiepitope Melanoma Peptides-B7.1-B7.2 Vaccine
C48639	Synthetic_Melanoma-Associated_Antigens_Vaccine	Vaccine_Antigen	Synthetic Melanoma-Associated Antigens Vaccine
C48640	APC8015F	Autologous_Cell_Vaccine|Dendritic_Cell_Tumor_Peptide_Vaccine	APC8015F|APC 8015F
C48646	Therapeutic_Norepinephrine	Alpha-adrenergic_Agonist	Norepinephrine Bitartrate|(2R,3R)-(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol, 2,3-Dihydoxybutanedioate Monohydrate (1:1) (Salt)|NOREPINEPHRINE BITARTRATE
C48647	University	Professional_Organization_or_Group	University|UNIV	A large and diverse institution of higher learning created to educate for life and for a profession and to grant degrees; an establishment where a seat of higher learning is housed, including administrative and living quarters as well as facilities for research and teaching; the body of faculty and students at a university.
C48648	Brother_Title	Title	Brother	A courtesy title for a member of a religious order, fraternity, movement, or other group.
C48649	Sister_Title	Title	Sister	A courtesy title for a member of a religious order, fraternity, movement, the nursing profession, or other group.
C48655	Missing_Value_Reason	General_Modifier	Missing Value Reason|MVR|missing value reason	A specific reason explaining why a meaningful value is not available.  A meaningful value answers the question posed by a Data Element Concept.  In contrast, a Missing Value Reason answers the implicit question "Why is there no 'meaningful' value?", when there is none.
C48657	Cannot_Be_Assessed	Missing_Value_Reason	Cannot Be Assessed|Cannot be Assessed|cannot be assessed	Aspects of the context prevent the evaluation needed to determine a value.
C48658	Indeterminate	Missing_Value_Reason	Indeterminate|Cannot Be Determined|cannot be determined|indeterminate	Cannot distinguish between two or more possible values in the current context.
C48660	Not_Applicable	Missing_Value_Reason	Not Applicable|not applicable	Determination of a value is not relevant in the current context.
C48661	Not_Identified	Missing_Value_Reason	Not Identified|not identified	The finding is not present, but a value of 'none' cannot be unequivocally established absence in the current context.
C48662	Marked	Quantity	Marked|Brisk
C48663	Postero-Lateral_Part_of_the_Prostate	Male_Reproductive_System_Part	Posterolateral Part of the Prostate|Postero-Lateral Part of the Prostate
C48664	Gene_Identifier	Identifier	Gene Identifier|Gene ID|Gene Name	A unique gene name within a specific repository, database, or collection.
C48665	Elapse	Temporal_Modifier	Elapse|Elapsed	To pass by; having passed by.
C48666	Low_Penetrance_Allele	Gene	Low Penetrance Allele|Low Penetrant Allele	A gene with a low probability of expression as a phenotype.
C48667	Penetrance	Gene_Expression_Process	Penetrance|Genetic Penetrance	The degree or probability to which a genotype is expressed as a phenotype. (from www.dddmag.com)
C48668	Targeted_Mutation	Induced_Mutation	Targeted Mutation|Targeted DNA Alteration|Targeted DNA Modification|Targeted Modification|Targeted Sequence Alteration	A mutation created in a gene at a specific location.
C48669	Publication_Activity	Clinical_or_Research_Activity	Publication|Published	The act of issuing printed materials.
C48670	Schedule_of_Controlled_Substances	Attributes_of_Chemicals	Schedule of Controlled Substances|SPL DEA Schedule|SPL DEA Schedule of Controlled Substances|Structured Product Labeling and Drug Enforcement Administration Schedule of Controlled Substances	The abuse potential category to which an active ingredient, or combination of active ingredients, is assigned, as regulated by both the United States Drug Enforcement Administration (DEA) and the United States Food and Drug Administration.
C48671	Core_Genotyping_Facility	Nucleic_Acid_Core_Facility	Core Genotyping Facility|CGF|core genotyping facility	A facility to perform high-throughput genotyping and sequencing to support genetic analysis for a broad range of projects.
C48672	Schedule_I_Substance	Schedule_of_Controlled_Substances	Schedule I Substance|CI|SPL DEA Schedule I|Schedule I	Schedule I.
C48673	Genomic_Orientation	Miscellaneous_Molecular_Biology_Terms	Genomic Orientation|genomic orientation	The orientation of a genomic element on the double stranded molecule.
C48674	Preclinical	General_Modifier	Preclinical|Pre-clinical	Refers to in vitro testing or in vivo animal testing before clinical trials in humans are to be carried out.
C48675	Schedule_II_Substance	Schedule_of_Controlled_Substances	Schedule II Substance|CII|SPL DEA Schedule II|Schedule II	Schedule II.
C48676	Schedule_III_Substance	Schedule_of_Controlled_Substances	Schedule III Substance|CIII|SPL DEA Schedule III|Schedule III	Schedule III.
C48677	Schedule_IV_Substance	Schedule_of_Controlled_Substances	Schedule IV Substance|CIV|SPL DEA Schedule IV|Schedule IV	Schedule IV.
C48678	Preclinical_Study	Research_Activity	Preclinical Study|Preclinical Trial|preclinical study	A study to test a drug, procedure or other medical treatment in animals. The aim is to collect data in support of safety. Preclinical studies are required before clinical trials can be started. (On-line Medical Dictionary)
C48679	Schedule_V_Substance	Schedule_of_Controlled_Substances	Schedule V Substance|CV|SPL DEA Schedule V|Schedule V	Schedule V.
C48680	VKORC1_Gene	Regulatory_Gene	VKORC1 Gene|MST134|MST576|UNQ308|VKCFD2|VKORC1|Vitamin K Epoxide Reductase Complex, Subunit 1 Gene	Human VKORC1 gene is located on chromosome 16p11.2 and is ~4.7 Kb in length. This gene encodes human vitamin K epoxide reductase complex subunit 1 protein, is localized in the cytoplasm and highly expressed in the liver. The gene is involved in vitamin K metabolism and has been identified as a genetic marker to predict biological responses to the anti-clotting drug warfarin.
C48681	VKORC1_Protein	Regulatory_Protein	Vitamin K Epoxide Reductase Complex, Subunit 1	Human vitamin K epoxide reductase complex, subunit 1 protein (163 aa, ~18.2 kDa) is encoded by the human vitamin K epoxide reductase complex, subunit 1 (VKORC1) gene. The protein is an integral membrane protein that is localized to the endoplasmic reticulum; and plays a role in vitamin K metabolism. The protein also plays an important role in blood coagulation.
C48682	Neoplastic_Fibroblast	Neoplastic_Connective_and_Soft_Tissue_Spindle_Cell	Neoplastic Fibroblast
C48683	Neoplastic_Lipocyte	Neoplastic_Connective_and_Soft_Tissue_Cell	Neoplastic Lipocyte
C48684	PARP1_Gene	DNA_Repair_Gene	PARP1 Gene|PARP1|Poly(ADP Ribose) Polymerase Gene	The human PARP1 gene is located on chromosome 1q42 and is ~47 Kb in length. The gene is localized to the nucleus and is associated with heterochromatin structures. The primary function of the gene is DNA repair.
C48685	Insertion	Clinical_or_Research_Activity	Insertion|Inserted	The act of putting one thing into another.
C48686	Tumor_Model	Experimental_Model	Tumor Model|tumor model	Cells, tissues, or animals used to study the development and progression of cancer, and to test new treatments before they are given to humans. Animals with transplanted human tumors or other tissues are called xenograft models.
C48687	Skeletal_Muscle_Cell	Striated_Muscle_Tissue_Cell	Skeletal Muscle Cell|Skeletal Muscle Tissue Cell
C48689	Remnants_of_the_Notochord	Connective_and_Soft_Tissue	Remnants of the Notochord
C48690	Human_Genome_Organisation	Professional_Organization_or_Group	Human Genome Organisation|HUGO|Human Genome Organization	An international organization of scientists involved in human genetics. Established in 1989 by a collection of the world's leading human geneticists, the primary ethos of the Human Genome Organisation is to promote and sustain international collaboration in the field of human genetics.
C48691	Coding_Region	Gene_Structure	Coding Region|Coding Feature|Coding Sequence|Protein Coding Region|Protein Coding Sequence	The sequences on a gene or messenger RNA that are translated into protein.
C48692	Subsystem	System	Subsystem	A system that is part of some larger system.
C48693	Data_Table	Conceptual_Entities	Data Table|Table	A set of data arranged in rows and columns.
C48694	Cell_Space	Conceptual_Entities	Cell|Cell Space	Any small compartment.
C48695	Cartilage_Cell	Connective_and_Soft_Tissue_Cell	Cartilage Cell
C48696	Neoplastic_Cartilage_Cell	Neoplastic_Connective_and_Soft_Tissue_Cell	Neoplastic Cartilage Cell
C48697	Controlled_Vocabulary	Vocabulary_Object	Controlled Vocabulary	A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when cataloging, indexing, or searching books, journals, and other documents. The control is intended to avoid the scattering of related subjects under different headings.
C48698	Cancer_TNM_Finding_Category	Cancer_TNM_Finding	Cancer TNM Finding Category
C48699	M0_Stage_Finding	Cancer_TNM_Finding_Category	M0 Stage Finding|M0|M0 Cancer Stage Finding|M0 Distant Metastasis Finding|M0 Distant Metastasis Stage Finding|M0 Metastasis Finding|M0 Metastasis Stage|M0 Stage|M0 TNM Finding|Metastasis Stage M0	No evidence of distant metastasis, in accordance with TNM classification system guidelines. (from AJCC 6th Ed.)
C48700	M1_Stage_Finding	Cancer_TNM_Finding_Category	M1 Stage Finding|M1|M1 Cancer Stage Finding|M1 Distant Metastasis Finding|M1 Distant Metastasis Stage Finding|M1 Metastasis Finding|M1 Metastasis Stage|M1 Stage|M1 TNM Finding|Metastasis Stage M1
C48701	M1a_Stage_Finding	M1_Stage_Finding	M1a Stage Finding|M1a|M1a Cancer Stage Finding|M1a Distant Metastasis Finding|M1a Distant Metastasis Stage Finding|M1a Metastasis Finding|M1a Metastasis Stage|M1a Stage|M1a TNM Finding|Metastasis Stage M1a
C48702	M1b_Stage_Finding	M1_Stage_Finding	M1b Stage Finding|M1b|M1b Cancer Stage Finding|M1b Distant Metastasis Finding|M1b Distant Metastasis Stage Finding|M1b Metastasis Finding|M1b Metastasis Stage|M1b Stage|M1b TNM Finding|Metastasis Stage M1b
C48703	M1c_Stage_Finding	M1_Stage_Finding	M1c Stage Finding|M1c|M1c Cancer Stage Finding|M1c Distant Metastasis Finding|M1c Distant Metastasis Stage Finding|M1c Metastasis Finding|M1c Metastasis Stage|M1c Stage|M1c TNM Finding|Metastasis Stage M1c
C48704	MX_Stage_Finding	Cancer_TNM_Finding_Category	MX Stage Finding|MX|MX Cancer Stage Finding|MX Distant Metastasis Finding|MX Distant Metastasis Stage Finding|MX Metastasis Finding|MX Metastasis Stage|MX Stage|MX TNM Finding|Metastasis Stage MX	Status of distant metastasis cannot be assessed in accordance with TNM classification system guidelines. (from AJCC 6th Ed.)
C48705	N0_Stage_Finding	Cancer_TNM_Finding_Category	N0 Stage Finding|Lymph Node Stage N0|N0|N0 Cancer Stage Finding|N0 Lymph Node Finding|N0 Lymph Node Stage|N0 Node Finding|N0 Node Stage|N0 Regional Lymph Node Stage Finding|N0 Regional Lymph Nodes Finding|N0 Stage|N0 TNM Finding|Node Stage N0	No evidence of regional lymph node metastasis, in accordance with TNM classification system guidelines. (from AJCC 6th Ed.)
C48706	N1_Stage_Finding	Cancer_TNM_Finding_Category	N1 Stage Finding|Lymph Node Stage N1|N1|N1 Cancer Stage Finding|N1 Lymph Node Finding|N1 Lymph Node Stage|N1 Node Finding|N1 Node Stage|N1 Regional Lymph Node Stage Finding|N1 Regional Lymph Nodes Finding|N1 Stage|N1 TNM Finding|Node Stage N1
C48707	N1a_Stage_Finding	N1_Stage_Finding	N1a Stage Finding|Lymph Node Stage N1a|N1a|N1a Cancer Stage Finding|N1a Lymph Node Finding|N1a Lymph Node Stage|N1a Node Finding|N1a Node Stage|N1a Regional Lymph Node Stage Finding|N1a Regional Lymph Nodes Finding|N1a Stage|N1a TNM Finding|Node Stage N1a
C48708	N1b_Stage_Finding	N1_Stage_Finding	N1b Stage Finding|Lymph Node Stage N1b|N1b|N1b Cancer Stage Finding|N1b Lymph Node Finding|N1b Lymph Node Stage|N1b Node Finding|N1b Node Stage|N1b Regional Lymph Node Stage Finding|N1b Regional Lymph Nodes Finding|N1b Stage|N1b TNM Finding|Node Stage N1b
C48709	N1c_Stage_Finding	N1_Stage_Finding	N1c Stage Finding|Lymph Node Stage N1c|N1c|N1c Cancer Stage Finding|N1c Lymph Node Finding|N1c Lymph Node Stage|N1c Node Finding|N1c Node Stage|N1c Regional Lymph Node Stage Finding|N1c Regional Lymph Nodes Finding|N1c Stage|N1c TNM Finding|Node Stage N1c
C48711	N2a_Stage_Finding	N2_Stage_Finding	N2a Stage Finding|Lymph Node Stage N2a|N2a|N2a Cancer Stage Finding|N2a Lymph Node Finding|N2a Lymph Node Stage|N2a Node Finding|N2a Node Stage|N2a Regional Lymph Node Stage Finding|N2a Regional Lymph Nodes Finding|N2a Stage|N2a TNM Finding|Node Stage N2a
C48712	N2b_Stage_Finding	N2_Stage_Finding	N2b Stage Finding|Lymph Node Stage N2b|N2b|N2b Cancer Stage Finding|N2b Lymph Node Finding|N2b Lymph Node Stage|N2b Node Finding|N2b Node Stage|N2b Regional Lymph Node Stage Finding|N2b Regional Lymph Nodes Finding|N2b Stage|N2b TNM Finding|Node Stage N2b
C48713	N2c_Stage_Finding	N2_Stage_Finding	N2c Stage Finding|Lymph Node Stage N2c|N2c|N2c Cancer Stage Finding|N2c Lymph Node Finding|N2c Lymph Node Stage|N2c Node Finding|N2c Node Stage|N2c Regional Lymph Node Stage Finding|N2c Regional Lymph Nodes Finding|N2c Stage|N2c TNM Finding|Node Stage N2c
C48714	N3_Stage_Finding	Cancer_TNM_Finding_Category	N3 Stage Finding|Lymph Node Stage N3|N3|N3 Cancer Stage Finding|N3 Lymph Node Finding|N3 Lymph Node Stage|N3 Node Finding|N3 Node Stage|N3 Regional Lymph Node Stage Finding|N3 Regional Lymph Nodes Finding|N3 Stage|N3 TNM Finding|Node Stage N3
C48715	N3a_Stage_Finding	N3_Stage_Finding	N3a Stage Finding|Lymph Node Stage N3a|N3a|N3a Cancer Stage Finding|N3a Lymph Node Finding|N3a Lymph Node Stage|N3a Node Finding|N3a Node Stage|N3a Regional Lymph Node Stage Finding|N3a Regional Lymph Nodes Finding|N3a Stage|N3a TNM Finding|Node Stage N3a
C48716	N3b_Stage_Finding	N3_Stage_Finding	N3b Stage Finding|Lymph Node Stage N3b|N3b|N3b Cancer Stage Finding|N3b Lymph Node Finding|N3b Lymph Node Stage|N3b Node Finding|N3b Node Stage|N3b Regional Lymph Node Stage Finding|N3b Regional Lymph Nodes Finding|N3b Stage|N3b TNM Finding|Node Stage N3b
C48717	N3c_Stage_Finding	N3_Stage_Finding	N3c Stage Finding|Lymph Node Stage N3c|N3c|N3c Cancer Stage Finding|N3c Lymph Node Finding|N3c Lymph Node Stage|N3c Node Finding|N3c Node Stage|N3c Regional Lymph Node Stage Finding|N3c Regional Lymph Nodes Finding|N3c Stage|N3c TNM Finding|Node Stage N3c
C48718	NX_Stage_Finding	Cancer_TNM_Finding_Category	NX Stage Finding|Lymph Node Stage NX|NX|NX Cancer Stage Finding|NX Lymph Node Finding|NX Lymph Node Stage|NX Node Finding|NX Node Stage|NX Regional Lymph Node Stage Finding|NX Regional Lymph Nodes Finding|NX Stage|NX TNM Finding|Node Stage NX	Status of regional lymph nodes cannot be assessed in accordance with TNM classification system guidelines. (from AJCC 6th Ed.)
C48719	T0_Stage_Finding	Cancer_TNM_Finding_Category	T0 Stage Finding|T0|T0 Cancer Stage Finding|T0 Primary Tumor Finding|T0 Primary Tumor Stage Finding|T0 Stage|T0 TNM Finding|T0 Tumor Finding|T0 Tumor Stage|Tumor Stage T0	No evidence of primary tumor, in accordance with TNM classification system guidelines. (from AJCC 6th Ed.)
C48720	T1_Stage_Finding	Cancer_TNM_Finding_Category	T1 Stage Finding|T1|T1 Cancer Stage Finding|T1 Primary Tumor Finding|T1 Primary Tumor Stage Finding|T1 Stage|T1 TNM Finding|T1 Tumor Finding|T1 Tumor Stage|Tumor Stage T1
C48721	T1a_Stage_Finding	T1_Stage_Finding	T1a Stage Finding|T1a|T1a Cancer Stage Finding|T1a Primary Tumor Finding|T1a Primary Tumor Stage Finding|T1a Stage|T1a TNM Finding|T1a Tumor Finding|T1a Tumor Stage|Tumor Stage T1a
C48722	T1b_Stage_Finding	T1_Stage_Finding	T1b Stage Finding|T1b|T1b Cancer Stage Finding|T1b Primary Tumor Finding|T1b Primary Tumor Stage Finding|T1b Stage|T1b TNM Finding|T1b Tumor Finding|T1b Tumor Stage|Tumor Stage T1b
C48723	T1c_Stage_Finding	T1_Stage_Finding	T1c Stage Finding|T1c|T1c Cancer Stage Finding|T1c Primary Tumor Finding|T1c Primary Tumor Stage Finding|T1c Stage|T1c TNM Finding|T1c Tumor Finding|T1c Tumor Stage|Tumor Stage T1c
C48724	T2_Stage_Finding	Cancer_TNM_Finding_Category	T2 Stage Finding|T2|T2 Cancer Stage Finding|T2 Primary Tumor Finding|T2 Primary Tumor Stage Finding|T2 Stage|T2 TNM Finding|T2 Tumor Finding|T2 Tumor Stage|Tumor Stage T2
C48725	T2a_Stage_Finding	T2_Stage_Finding	T2a Stage Finding|T2a|T2a Cancer Stage Finding|T2a Primary Tumor Finding|T2a Primary Tumor Stage Finding|T2a Stage|T2a TNM Finding|T2a Tumor Finding|T2a Tumor Stage|Tumor Stage T2a
C48726	T2b_Stage_Finding	T2_Stage_Finding	T2b Stage Finding|T2b|T2b Cancer Stage Finding|T2b Primary Tumor Finding|T2b Primary Tumor Stage Finding|T2b Stage|T2b TNM Finding|T2b Tumor Finding|T2b Tumor Stage|Tumor Stage T2b
C48727	T2c_Stage_Finding	T2_Stage_Finding	T2c Stage Finding|T2c|T2c Cancer Stage Finding|T2c Primary Tumor Finding|T2c Primary Tumor Stage Finding|T2c Stage|T2c TNM Finding|T2c Tumor Finding|T2c Tumor Stage|Tumor Stage T2c
C48728	T3_Stage_Finding	Cancer_TNM_Finding_Category	T3 Stage Finding|T3|T3 Cancer Stage Finding|T3 Primary Tumor Finding|T3 Primary Tumor Stage Finding|T3 Stage|T3 TNM Finding|T3 Tumor Finding|T3 Tumor Stage|Tumor Stage T3
C48729	T3a_Stage_Finding	T3_Stage_Finding	T3a Stage Finding|T3a|T3a Cancer Stage Finding|T3a Primary Tumor Finding|T3a Primary Tumor Stage Finding|T3a Stage|T3a TNM Finding|T3a Tumor Finding|T3a Tumor Stage|Tumor Stage T3a
C48730	T3b_Stage_Finding	T3_Stage_Finding	T3b Stage Finding|T3b|T3b Cancer Stage Finding|T3b Primary Tumor Finding|T3b Primary Tumor Stage Finding|T3b Stage|T3b TNM Finding|T3b Tumor Finding|T3b Tumor Stage|Tumor Stage T3b
C48731	T3c_Stage_Finding	T3_Stage_Finding	T3c Stage Finding|T3c|T3c Cancer Stage Finding|T3c Primary Tumor Finding|T3c Primary Tumor Stage Finding|T3c Stage|T3c TNM Finding|T3c Tumor Finding|T3c Tumor Stage|Tumor Stage T3c
C48732	T4_Stage_Finding	Cancer_TNM_Finding_Category	T4 Stage Finding|T4|T4 Cancer Stage Finding|T4 Primary Tumor Finding|T4 Primary Tumor Stage Finding|T4 Stage|T4 TNM Finding|T4 Tumor Finding|T4 Tumor Stage|Tumor Stage T4
C48733	T4a_Stage_Finding	T4_Stage_Finding	T4a Stage Finding|T4a|T4a Cancer Stage Finding|T4a Primary Tumor Finding|T4a Primary Tumor Stage Finding|T4a Stage|T4a TNM Finding|T4a Tumor Finding|T4a Tumor Stage|Tumor Stage T4a
C48734	T4b_Stage_Finding	T4_Stage_Finding	T4b Stage Finding|T4b|T4b Cancer Stage Finding|T4b Primary Tumor Finding|T4b Primary Tumor Stage Finding|T4b Stage|T4b TNM Finding|T4b Tumor Finding|T4b Tumor Stage|Tumor Stage T4b
C48735	T4c_Stage_Finding	T4_Stage_Finding	T4c Stage Finding|T4c|T4c Cancer Stage Finding|T4c Primary Tumor Finding|T4c Primary Tumor Stage Finding|T4c Stage|T4c TNM Finding|T4c Tumor Finding|T4c Tumor Stage|Tumor Stage T4c
C48736	T4d_Stage_Finding	T4_Stage_Finding	T4d Stage Finding|T4d|T4d Cancer Stage Finding|T4d Primary Tumor Finding|T4d Primary Tumor Stage Finding|T4d Stage|T4d TNM Finding|T4d Tumor Finding|T4d Tumor Stage|Tumor Stage T4d
C48737	TX_Stage_Finding	Cancer_TNM_Finding_Category	TX Stage Finding|TX|TX Cancer Stage Finding|TX Primary Tumor Finding|TX Primary Tumor Stage Finding|TX Stage|TX TNM Finding|TX Tumor Finding|TX Tumor Stage|Tumor Stage TX	Status of the primary tumor cannot be assessed in accordance with TNM classification system guidelines. (from AJCC 6th Ed.)
C48738	Tis_Stage_Finding	Cancer_TNM_Finding_Category	Tis Stage Finding|Tis|Tis Cancer Stage Finding|Tis Primary Tumor Finding|Tis Primary Tumor Stage Finding|Tis Stage|Tis TNM Finding|Tis Tumor Finding|Tis Tumor Stage|Tumor Stage Tis
C48739	Pathologic_TNM_Finding	Cancer_TNM_Finding_Category	Pathologic TNM Finding
C48740	pM0_Stage_Finding	Pathologic_TNM_Finding	pM0 Stage Finding|Metastasis Stage pM0|pM0|pM0 Cancer Stage Finding|pM0 Distant Metastasis Finding|pM0 Distant Metastasis Stage Finding|pM0 Metastasis Finding|pM0 Metastasis Stage|pM0 Stage|pM0 TNM Finding	No morphologic evidence of distant metastasis, in accordance with TNM classification system guidelines.
C48741	pM1_Stage_Finding	Pathologic_TNM_Finding	pM1 Stage Finding|Metastasis Stage pM1|pM1|pM1 Cancer Stage Finding|pM1 Distant Metastasis Finding|pM1 Distant Metastasis Stage Finding|pM1 Metastasis Finding|pM1 Metastasis Stage|pM1 Stage|pM1 TNM Finding
C48742	pM1a_Stage_Finding	pM1_Stage_Finding	pM1a Stage Finding|Metastasis Stage pM1a|pM1a|pM1a Cancer Stage Finding|pM1a Distant Metastasis Finding|pM1a Distant Metastasis Stage Finding|pM1a Metastasis Finding|pM1a Metastasis Stage|pM1a Stage|pM1a TNM Finding
C48743	pM1b_Stage_Finding	pM1_Stage_Finding	pM1b Stage Finding|Metastasis Stage pM1b|pM1b|pM1b Cancer Stage Finding|pM1b Distant Metastasis Finding|pM1b Distant Metastasis Stage Finding|pM1b Metastasis Finding|pM1b Metastasis Stage|pM1b Stage|pM1b TNM Finding
C48744	pM1c_Stage_Finding	pM1_Stage_Finding	pM1c Stage Finding|Metastasis Stage pM1c|pM1c|pM1c Cancer Stage Finding|pM1c Distant Metastasis Finding|pM1c Distant Metastasis Stage Finding|pM1c Metastasis Finding|pM1c Metastasis Stage|pM1c Stage|pM1c TNM Finding
C48745	pN0_Stage_Finding	Pathologic_TNM_Finding	pN0 Stage Finding|Lymph Node Stage pN0|Node Stage pN0|pN0|pN0 Cancer Stage Finding|pN0 Lymph Node Finding|pN0 Lymph Node Stage|pN0 Node Finding|pN0 Node Stage|pN0 Regional Lymph Node Stage Finding|pN0 Regional Lymph Nodes Finding|pN0 Stage|pN0 TNM Finding	No morphologic evidence of regional lymph node metastasis by routine histologic staining, in accordance with TNM classification system guidelines.
C48746	pN1_Stage_Finding	Pathologic_TNM_Finding	pN1 Stage Finding|Lymph Node Stage pN1|Node Stage pN1|pN1|pN1 Cancer Stage Finding|pN1 Lymph Node Finding|pN1 Lymph Node Stage|pN1 Node Finding|pN1 Node Stage|pN1 Regional Lymph Node Stage Finding|pN1 Regional Lymph Nodes Finding|pN1 Stage|pN1 TNM Finding
C48747	pN1a_Stage_Finding	pN1_Stage_Finding	pN1a Stage Finding|Lymph Node Stage pN1a|Node Stage pN1a|pN1a|pN1a Cancer Stage Finding|pN1a Lymph Node Finding|pN1a Lymph Node Stage|pN1a Node Finding|pN1a Node Stage|pN1a Regional Lymph Node Stage Finding|pN1a Regional Lymph Nodes Finding|pN1a Stage|pN1a TNM Finding
C48748	pN1b_Stage_Finding	pN1_Stage_Finding	pN1b Stage Finding|Lymph Node Stage pN1b|Node Stage pN1b|pN1b|pN1b Cancer Stage Finding|pN1b Lymph Node Finding|pN1b Lymph Node Stage|pN1b Node Finding|pN1b Node Stage|pN1b Regional Lymph Node Stage Finding|pN1b Regional Lymph Nodes Finding|pN1b Stage|pN1b TNM Finding
C48749	pN1c_Stage_Finding	pN1_Stage_Finding	pN1c Stage Finding|Lymph Node Stage pN1c|Node Stage pN1c|pN1c|pN1c Cancer Stage Finding|pN1c Lymph Node Finding|pN1c Lymph Node Stage|pN1c Node Finding|pN1c Node Stage|pN1c Regional Lymph Node Stage Finding|pN1c Regional Lymph Nodes Finding|pN1c Stage|pN1c TNM Finding
C48750	pN2_Stage_Finding	Pathologic_TNM_Finding	pN2 Stage Finding|Lymph Node Stage pN2|Node Stage pN2|pN2|pN2 Cancer Stage Finding|pN2 Lymph Node Finding|pN2 Lymph Node Stage|pN2 Node Finding|pN2 Node Stage|pN2 Regional Lymph Node Stage Finding|pN2 Regional Lymph Nodes Finding|pN2 Stage|pN2 TNM Finding
C48751	pN2a_Stage_Finding	pN2_Stage_Finding	pN2a Stage Finding|Lymph Node Stage pN2a|Node Stage pN2a|pN2a|pN2a Cancer Stage Finding|pN2a Lymph Node Finding|pN2a Lymph Node Stage|pN2a Node Finding|pN2a Node Stage|pN2a Regional Lymph Node Stage Finding|pN2a Regional Lymph Nodes Finding|pN2a Stage|pN2a TNM Finding
C48752	pN2b_Stage_Finding	pN2_Stage_Finding	pN2b Stage Finding|Lymph Node Stage pN2b|Node Stage pN2b|pN2b|pN2b Cancer Stage Finding|pN2b Lymph Node Finding|pN2b Lymph Node Stage|pN2b Node Finding|pN2b Node Stage|pN2b Regional Lymph Node Stage Finding|pN2b Regional Lymph Nodes Finding|pN2b Stage|pN2b TNM Finding
C48753	pN2c_Stage_Finding	pN2_Stage_Finding	pN2c Stage Finding|Lymph Node Stage pN2c|Node Stage pN2c|pN2c|pN2c Cancer Stage Finding|pN2c Lymph Node Finding|pN2c Lymph Node Stage|pN2c Node Finding|pN2c Node Stage|pN2c Regional Lymph Node Stage Finding|pN2c Regional Lymph Nodes Finding|pN2c Stage|pN2c TNM Finding
C48754	pN3_Stage_Finding	Pathologic_TNM_Finding	pN3 Stage Finding|Lymph Node Stage pN3|Node Stage pN3|pN3|pN3 Cancer Stage Finding|pN3 Lymph Node Finding|pN3 Lymph Node Stage|pN3 Node Finding|pN3 Node Stage|pN3 Regional Lymph Node Stage Finding|pN3 Regional Lymph Nodes Finding|pN3 Stage|pN3 TNM Finding
C48755	pN3a_Stage_Finding	pN3_Stage_Finding	pN3a Stage Finding|Lymph Node Stage pN3a|Node Stage pN3a|pN3a|pN3a Cancer Stage Finding|pN3a Lymph Node Finding|pN3a Lymph Node Stage|pN3a Node Finding|pN3a Node Stage|pN3a Regional Lymph Node Stage Finding|pN3a Regional Lymph Nodes Finding|pN3a Stage|pN3a TNM Finding
C48756	pN3b_Stage_Finding	pN3_Stage_Finding	pN3b Stage Finding|Lymph Node Stage pN3b|Node Stage pN3b|pN3b|pN3b Cancer Stage Finding|pN3b Lymph Node Finding|pN3b Lymph Node Stage|pN3b Node Finding|pN3b Node Stage|pN3b Regional Lymph Node Stage Finding|pN3b Regional Lymph Nodes Finding|pN3b Stage|pN3b TNM Finding
C48757	pN3c_Stage_Finding	pN3_Stage_Finding	pN3c Stage Finding|Lymph Node Stage pN3c|Node Stage pN3c|pN3c|pN3c Cancer Stage Finding|pN3c Lymph Node Finding|pN3c Lymph Node Stage|pN3c Node Finding|pN3c Node Stage|pN3c Regional Lymph Node Stage Finding|pN3c Regional Lymph Nodes Finding|pN3c Stage|pN3c TNM Finding
C48758	pT0_Stage_Finding	Pathologic_TNM_Finding	pT0 Stage Finding|Tumor Stage pT0|pT0|pT0 Cancer Stage Finding|pT0 Primary Tumor Finding|pT0 Primary Tumor Stage Finding|pT0 Stage|pT0 TNM Finding|pT0 Tumor Finding|pT0 Tumor Stage	No morphologic evidence of primary tumor, in accordance with TNM classification system guidelines.
C48759	pT1_Stage_Finding	Pathologic_TNM_Finding	pT1 Stage Finding|Tumor Stage pT1|pT1|pT1 Cancer Stage Finding|pT1 Primary Tumor Finding|pT1 Primary Tumor Stage Finding|pT1 Stage|pT1 TNM Finding|pT1 Tumor Finding|pT1 Tumor Stage
C48760	pT1a_Stage_Finding	pT1_Stage_Finding	pT1a Stage Finding|Tumor Stage pT1a|pT1a|pT1a Cancer Stage Finding|pT1a Primary Tumor Finding|pT1a Primary Tumor Stage Finding|pT1a Stage|pT1a TNM Finding|pT1a Tumor Finding|pT1a Tumor Stage
C48761	pT1b_Stage_Finding	pT1_Stage_Finding	pT1b Stage Finding|Tumor Stage pT1b|pT1b|pT1b Cancer Stage Finding|pT1b Primary Tumor Finding|pT1b Primary Tumor Stage Finding|pT1b Stage|pT1b TNM Finding|pT1b Tumor Finding|pT1b Tumor Stage
C48762	Bone_Cell	Connective_and_Soft_Tissue_Cell	Bone Cell|Osseous Cell
C48763	pT1c_Stage_Finding	pT1_Stage_Finding	pT1c Stage Finding|Tumor Stage pT1c|pT1c|pT1c Cancer Stage Finding|pT1c Primary Tumor Finding|pT1c Primary Tumor Stage Finding|pT1c Stage|pT1c TNM Finding|pT1c Tumor Finding|pT1c Tumor Stage
C48764	pT2_Stage_Finding	Pathologic_TNM_Finding	pT2 Stage Finding|Tumor Stage pT2|pT2|pT2 Cancer Stage Finding|pT2 Primary Tumor Finding|pT2 Primary Tumor Stage Finding|pT2 Stage|pT2 TNM Finding|pT2 Tumor Finding|pT2 Tumor Stage
C48765	pT2a_Stage_Finding	pT2_Stage_Finding	pT2a Stage Finding|Tumor Stage pT2a|pT2a|pT2a Cancer Stage Finding|pT2a Primary Tumor Finding|pT2a Primary Tumor Stage Finding|pT2a Stage|pT2a TNM Finding|pT2a Tumor Finding|pT2a Tumor Stage
C48766	pT2b_Stage_Finding	pT2_Stage_Finding	pT2b Stage Finding|Tumor Stage pT2b|pT2b|pT2b Cancer Stage Finding|pT2b Primary Tumor Finding|pT2b Primary Tumor Stage Finding|pT2b Stage|pT2b TNM Finding|pT2b Tumor Finding|pT2b Tumor Stage
C48767	pT2c_Stage_Finding	pT2_Stage_Finding	pT2c Stage Finding|Tumor Stage pT2c|pT2c|pT2c Cancer Stage Finding|pT2c Primary Tumor Finding|pT2c Primary Tumor Stage Finding|pT2c Stage|pT2c TNM Finding|pT2c Tumor Finding|pT2c Tumor Stage
C48768	pT3_Stage_Finding	Pathologic_TNM_Finding	pT3 Stage Finding|Tumor Stage pT3|pT3|pT3 Cancer Stage Finding|pT3 Primary Tumor Finding|pT3 Primary Tumor Stage Finding|pT3 Stage|pT3 TNM Finding|pT3 Tumor Finding|pT3 Tumor Stage
C48769	pT3a_Stage_Finding	pT3_Stage_Finding	pT3a Stage Finding|Tumor Stage pT3a|pT3a|pT3a Cancer Stage Finding|pT3a Primary Tumor Finding|pT3a Primary Tumor Stage Finding|pT3a Stage|pT3a TNM Finding|pT3a Tumor Finding|pT3a Tumor Stage
C48770	pT3b_Stage_Finding	pT3_Stage_Finding	pT3b Stage Finding|Tumor Stage pT3b|pT3b|pT3b Cancer Stage Finding|pT3b Primary Tumor Finding|pT3b Primary Tumor Stage Finding|pT3b Stage|pT3b TNM Finding|pT3b Tumor Finding|pT3b Tumor Stage
C48771	pT3c_Stage_Finding	pT3_Stage_Finding	pT3c Stage Finding|Tumor Stage pT3c|pT3c Cancer Stage Finding|pT3c Primary Tumor Finding|pT3c Primary Tumor Stage Finding|pT3c Stage|pT3c TNM Finding|pT3c Tumor Finding|pT3c Tumor Stage
C48772	pT4_Stage_Finding	Pathologic_TNM_Finding	pT4 Stage Finding|Tumor Stage pT4|pT4|pT4 Cancer Stage Finding|pT4 Primary Tumor Finding|pT4 Primary Tumor Stage Finding|pT4 Stage|pT4 TNM Finding|pT4 Tumor Finding|pT4 Tumor Stage
C48773	pT4a_Stage_Finding	pT4_Stage_Finding	pT4a Stage Finding|Tumor Stage pT4a|pT4a|pT4a Cancer Stage Finding|pT4a Primary Tumor Finding|pT4a Primary Tumor Stage Finding|pT4a Stage|pT4a TNM Finding|pT4a Tumor Finding|pT4a Tumor Stage
C48774	pT4b_Stage_Finding	pT4_Stage_Finding	pT4b Stage Finding|Tumor Stage pT4b|pT4b|pT4b Cancer Stage Finding|pT4b Primary Tumor Finding|pT4b Primary Tumor Stage Finding|pT4b Stage|pT4b TNM Finding|pT4b Tumor Finding|pT4b Tumor Stage
C48775	pT4c_Stage_Finding	pT4_Stage_Finding	pT4c Stage Finding|Tumor Stage pT4c|pT4c|pT4c Cancer Stage Finding|pT4c Primary Tumor Finding|pT4c Primary Tumor Stage Finding|pT4c Stage|pT4c TNM Finding|pT4c Tumor Finding|pT4c Tumor Stage
C48776	pT4d_Stage_Finding	pT4_Stage_Finding	pT4d Stage Finding|Tumor Stage pT4d|pT4d|pT4d Cancer Stage Finding|pT4d Primary Tumor Finding|pT4d Primary Tumor Stage Finding|pT4d Stage|pT4d TNM Finding|pT4d Tumor Finding|pT4d Tumor Stage
C48777	Cancer_TNM_Vessel_Invasion_Finding_Category	Cancer_TNM_Finding	Cancer TNM Vessel Invasion Finding Category
C48778	L0_Stage_Finding	Cancer_TNM_Vessel_Invasion_Finding_Category	L0 Stage Finding|L0|L0 Cancer Stage Finding|L0 Lymphatic Invasion Finding|L0 Lymphatic Stage|L0 Lymphatic Vessel Invasion Finding|L0 Stage|L0 TNM Finding|Lymphatic Stage L0	No evidence of lymphatic vessel invasion, in accordance with TNM classification system guidelines. (from AJCC 6th Ed.)
C48779	L1_Stage_Finding	Cancer_TNM_Vessel_Invasion_Finding_Category	L1 Stage Finding|L1|L1 Cancer Stage Finding|L1 Lymphatic Invasion Finding|L1 Lymphatic Stage|L1 Lymphatic Vessel Invasion Finding|L1 Stage|L1 TNM Finding|Lymphatic Stage L1
C48780	LX_Stage_Finding	Cancer_TNM_Vessel_Invasion_Finding_Category	LX Stage Finding|LX|LX Cancer Stage Finding|LX Lymphatic Invasion Finding|LX Lymphatic Stage|LX Lymphatic Vessel Invasion Finding|LX Stage|LX TNM Finding|Lymphatic Stage LX	Status of lymphatic vessel invasion cannot be assessed in accordance with TNM classification system guidelines. (from AJCC 6th Ed.)
C48781	V0_Stage_Finding	Cancer_TNM_Vessel_Invasion_Finding_Category	V0 Stage Finding|V0|V0 Cancer Stage Finding|V0 Stage|V0 TNM Finding|V0 Venous Invasion Finding|V0 Venous Stage|Venous Stage V0	No evidence of venous invasion, in accordance with TNM classification system guidelines. (from AJCC 6th Ed.)
C48782	V1_Stage_Finding	Cancer_TNM_Vessel_Invasion_Finding_Category	V1 Stage Finding|V1|V1 Cancer Stage Finding|V1 Stage|V1 TNM Finding|V1 Venous Invasion Finding|V1 Venous Stage|Venous Stage V1
C48783	V2_Stage_Finding	Cancer_TNM_Vessel_Invasion_Finding_Category	V2 Stage Finding|V2|V2 Cancer Stage Finding|V2 Stage|V2 TNM Finding|V2 Venous Invasion Finding|V2 Venous Stage|Venous Stage V2
C48784	VX_Stage_Finding	Cancer_TNM_Vessel_Invasion_Finding_Category	VX Stage Finding|VX|VX Cancer Stage Finding|VX Stage|VX TNM Finding|VX Venous Invasion Finding|VX Venous Stage|Venous Stage VX	Status of venous invasion cannot be assessed in accordance with TNM classification system guidelines. (from AJCC 6th Ed.)
C48785	Protein_Information_Resource	Information_Resources	Protein Information Resource|PIR	An integrated public bioinformatics resource to support genomic and proteomic research and scientific studies; provides protein databases and analysis tools freely accessible to the scientific community. Today, PIR offers a wide variety of resources mainly oriented to assist the propagation and standarization of protein annotation. Among these are: PIRSF, which provides curated protein families with rules for functional site and protein name; iProLink, that supports text mining in the area of literature-based database curation, named entity recognition, and protein ontology development; and iProClass, which contains value-added annotation reports for UniProt proteins.
C48786	N2_Stage_Finding	Cancer_TNM_Finding_Category	N2 Stage Finding|Lymph Node Stage N2|N2|N2 Cancer Stage Finding|N2 Lymph Node Finding|N2 Lymph Node Stage|N2 Node Finding|N2 Node Stage|N2 Regional Lymph Node Stage Finding|N2 Regional Lymph Nodes Finding|N2 Stage|N2 TNM Finding|Node Stage N2
C48787	Malignant_Connective_and_Soft_Tissue_Cell	Malignant_Cell|Neoplastic_Connective_and_Soft_Tissue_Cell	Malignant Connective and Soft Tissue Cell
C48788	Subunit	Part	Subunit	A single unit of a multimeric object.
C48789	Dual_X-ray_Absorptometry	Procedure	Dual X-ray Absorptometry|DEXA|DXA|Dual Energy X-ray Absorptometry|Dual X-Ray Absorptiometry	A technique for scanning bone and measuring bone mineral density (BMD). A DXA scanner produces 2 X-ray beams, each with different energy levels. One beam is high energy while the other is low energy. The amount of x-rays that pass through the bone is measured for each beam. This will vary depending on the thickness of the bone. Based on the difference between the 2 beams, the bone density can be measured. (MedicineNet.com)
C48790	Breast_Cancer_TNM_Finding	Cancer_TNM_Finding_by_Site	Breast Cancer TNM Finding|Breast Carcinoma TNM Finding|Cancer of the Breast TNM Finding|Carcinoma of the Breast TNM Finding
C48791	Cutaneous_Melanoma_TNM_Finding	Cancer_TNM_Finding_by_Site	Cutaneous Melanoma TNM Finding|Cutaneous Melanoma|Melanoma of Skin TNM Finding|Melanoma of the Skin TNM Finding|Skin Melanoma TNM Finding
C48792	Element_Part	Part	Element	An artifact that is one of the individual parts of which a composite entity is made up; especially a part that can be separated from or attached to a system.
C48793	Equivalent	General_Modifier	Equivalent	A person or thing equal to another in value or measure or force or effect or significance etc; being essentially equal to something.
C48794	Summation	Document_Type	Summation	A concluding part of a speech or argument containing a summary of principal points.
C48795	Residue	Conceptual_Entities	Residue	A single unit within a polymer; a recognizable molecular fragment embedded in a larger molecule.
C48796	VIM_Gene	Intermediate_Filament_Gene	VIM Gene|VIM|Vimentin Gene	Human VIM gene is located on chromosome 10p13 and is ~8.3 Kb in length. This gene is localized to the cytoplasm and cytoskeleton, and plays an important role in mesynchemal tissues during embryogenesis. The gene has also been identified as a genetic marker for colon cancer.
C48797	Vimentin_Protein	Intermediate_Filament_Protein	Vimentin Protein	Human vimentin protein (465 aa, ~53.5 kDa) is encoded by the human vimentin (VIM) gene. This phosphoprotein is highly expressed in fibroblasts; and is a structural protein belonging to the intermediate filament family.
C48798	Prostate_Specific_Antigen_Velocity	Properties_or_Attributes	Prostate Specific Antigen Velocity|PSA Velocity	The rate of change in the prostate specific antigen (PSA) level over time. PSA is a protein produced by the cells of the prostate, which can be measured in the serum of blood. Increasing levels of the protein may indicate that prostate cancer is present.
C48799	In_Vivo_Imaging	Imaging_Technique	In Vivo Imaging|Imaging In Vivo	A microscopic visual representation of a biological component inside the body. The imaging procedure often utilizes a variety of diagnostic tools to provide insight regarding disease states, molecular characterization, and biological processes.
C48800	Biorepository	Repository_of_Specimens_and_Reagents	Biorepository	A storage facility of biospecimens that includes tissue samples, fluids, and molecular derivatives such as DNA, RNA, and proteins. The biorepository has stringent guidelines regarding the standardized collection, handling, storage, and documentation of biological specimens.
C48801	Vital_Exhaustion	Reactive_Depression	Vital Exhaustion	A condition characterized by excessive fatigue and lack of energy, increasing irritability, and feelings of demoralization. Persons who experience this condition are not at an increased risk for cancer.
C48803	Polymer	Drugs_and_Chemicals_Structural_Classification	Polymer	A molecule made up of a linked series of repeated monomers.
C48804	Repeat_Object	Conceptual_Entities	Repeat Object|Repeat	Something occurring more than once.
C48805	Regulation	Biological_Process	Regulation	The act of controlling the rate or manner in which a process progresses or a product is formed.
C48806	Regulator	Conceptual_Entities	Regulator	Something that controls the rate or manner in which a process progresses or a product is formed.
C48807	Chemical	Conceptual_Entities	Chemical	A substance with a defined atomic or molecular structure that results from, or takes part in, reactions involving changes in its structure, composition, or properties.
C48808	Chemical_Formula	Conceptual_Entities	Chemical Formula|Formula	A representation of a substance using symbols for its constituent elements.
C48809	Small_Molecule	Conceptual_Entities	Small Molecule	A molecule that is not determined by a genome sequence.
C48810	Catalyst	Drugs_and_Chemicals_Functional_Classification	Catalyst	A substance that initiates or accelerates a chemical reaction without itself being affected.
C48811	Orthologous	General_Modifier	Orthologous	Occurring in one species but corresponding to one in another species that is related via a common ancestral species.
C48812	PXD101	Histone_Deacetylase_Inhibitor	PXD101|PXD 101
C48813	_5-Iodo-2-Pyrimidinone-2-Deoxyribose	Radiosensitizing_Agent	5-Iodo-2-pyrimidinone-2'-deoxyribose
C48814	Melanoma_Tumor-Reactive_Autologous_Tumor_Infiltrating_Lymphocytes	Autologous_Lymphocytes	Melanoma Tumor-Reactive Autologous Tumor Infiltrating Lymphocytes|Melanoma Tumor-Reactive Autologous TIL
C48815	UniSTS	Information_Resources	UniSTS	A comprehensive database of sequence tagged sites (STSs) derived from STS-based maps and other experiments providing a unified, non-redundant view of sequence tagged sites. UniSTS integrates marker and mapping data from a variety of public resources.
C48816	Renal_Tumor-Reactive_Autologous_Peripheral_Blood_Lymphocytes	Autologous_Lymphocytes	Renal Tumor-Reactive Autologous Peripheral Blood Lymphocytes|Melanoma Tumor-Reactive Autologous PBL
C48817	Renal_Tumor-Reactive_Autologous_Tumor_Infiltrating_Lymphocytes	Autologous_Lymphocytes	Renal Tumor-Reactive Autologous Tumor Infiltrating Lymphocytes|Renal Tumor-Reactive Autologous TIL
C48818	Adeno-Associated_Virus_Type_2	Parvovirus	Adeno-Associated Virus Type 2|AAV2	This strain of viridae is a non-pathogenic human parvovirus that is icosahedral, 20-25 nm in diameter, minus sense, and comprised of a 5 kb. single-stranded DNA genome. The virus is generally monomorphic and has been developed as a gene therapy vector for the treatment of numerous diseases. Wild-type AA-2 retains the ability to preferentially integrate its DNA into a 4 kilobase region of human chromosome 19, designated AAVS1, making it an attractive gene therapy vehicle. The virus has demonstrated anti-cancer activity by inducing apoptosis and inhibiting the growth of cancer cells.
C48819	HomoloGene	Information_Resources	HomoloGene	A system provided by the National Center for Biotechnology Information for automated detection of homologs among the annotated genes of several completely sequenced eukaryotic genomes.
C48820	Annotated_Tissue	Specimen	Annotated Tissue	A concise, detailed, description record of cell specimen(s) or tissues for clinical and laboratory applications. The information recorded contains explanatory guidelines or notes regarding the sample. This data collection enables multiple disciplines with special expertise in the diagnosis and treatment of carcinomas to facilitate the conduct of clinical- and laboratory-based cancer research.
C48821	Jaw	Irregular_Bone	Jaw
C48822	Upper_Jaw	Jaw	Upper Jaw
C48823	Lower_Jaw	Jaw	Lower Jaw
C48824	Lumbosacral_Region	Body_Region	Lumbosacral Region
C48825	MC1R_Gene	Regulatory_Gene	MC1R Gene|MC1R|MSHR|Melanocortin 1 Receptor (Alpha Melanocyte Stimulating Hormone Receptor) Gene	The human MC1R gene is located on chromosome 16q24.3 and is 2.36 Kb in length. This gene is localized extracellularly on the plasma membrane of cells, with an increased concentration on melanosomes. The gene plays an important role in the regulation of skin pigmentation. Variants of this gene have been linked to increased melanoma risk.
C48827	MC1R_Protein	G_Protein	MC1R Protein|Melanocortin 1 Receptor	Human melanocortin 1 receptor protein (317 aa, ~34.7 kDa) is encoded by the melanocortin 1 receptor gene (MC1R). This integral membrane protein belongs to the G protein coupled receptor superfamily, and is a regulator of eumelanin and phaeomelanin production.  These proteins are directly involved in pigmentation phenotypes.
C48829	Primary_Lymphedema	Lymphedema	Primary Lymphedema	A congenital condition that results in swelling in the arms or legs, and can occur during adolescence or adulthood. Loss of motion and pain may also accompany the swelling. Protein-rich lymphatic fluid accumulates in tissues, engorging and enlarging vessels and often causing visible swelling, tenderness, and pain. Left untreated, the affected tissues may continue to swell, and can become hardened or fibrotic and susceptible to infection.
C48830	Secondary_Lymphedema	Lymphedema	Secondary Lymphedema	A condition that is caused by trauma to the lymph system, which disrupts the normal flow of lymph fluid. This is most often due to surgery that requires lymph node removal or a large amount of lymph tissue. This disruption is especially apparent if the lymph nodes under the arm and arm and around the breast are compromised due to breast cancer surgery, diagnostic dissection, mastectomy, or radiation.
C48832	Patient_Navigator	Health_Care_Provider	Patient Navigator	Persons who can be trained to guide and support those requiring assistance obtaining medical care. Such persons are sensitive to socio-economic factors within the community and provide a variety of services. Their primary responsibilities are to assist patients that have an abnormal examination or a positive finding to navigate through the health care system.
C48833	Fellowship_for_the_Interpretation_of_Genomes	Clinical_or_Research_Facility	Fellowship for the Interpretation of Genomes|FIG|fellowship for the interpretation of genomes	A non-profit organization specializing in bioinformatics tool development and comparative genomics research.
C48834	Correlation	Conceptual_Entities	Correlation	The degree to which two or more quantities or events are linearly associated, a statistical relation between two or more variables such that systematic changes in the value of one variable are accompanied by systematic changes in the others.
C48835	Role_Generic	Conceptual_Entities	Role|Functional Role|Generic Role|role generic	The usual or expected function of something; the part something plays in an action or event.
C48836	GRP78_Protein	Stress-Induced_Protein	GRP78 Protein|BiP Protein|GRP 78 Protein|Immunoglobulin Heavy Chain Binding Protein	Human GRP78 protein (654 aa, 72kDa) is encoded by the heat shock 70kDa protein 5 (HSPA5) gene. The protein is intracellularly localized in the endoplasmic reticulum lumen, and plays a role in the assembly of multimeric protein complexes inside the organelle. In addition, the protein is thought to function as a pro-survival protein, or an inhibitor of apoptosis.
C48837	HSPA5_Gene	Chaperone_Gene	HSPA5 Gene|D7G6|GRP78|Heat Shock 70kDa Protein 5 (Glucose-Regulated Protein, 78kDa) Gene|IGH-BIP Gene	Human HSPA5 gene is located on chromosome 9q34 and is ~6.48 Kb in length. The gene encodes human GRP78 protein, and is localized outside the cell at the plasma membrane and inside the cell in the endoplasmic reticulum. HSPA5 has been implicated in gastric tumor development.
C48838	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous_Melanoma_TNM_Finding	Cutaneous Melanoma Pathologic TNM Finding
C48839	Cutaneous_Melanoma_pTX_TNM_Finding	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous Melanoma pTX TNM Finding|pTX Cutaneous Melanoma|pTX Melanoma of Skin|pTX Melanoma of the Skin|pTX Skin Melanoma	Cutaneous melanoma in which the primary tumor cannot be assessed. (from AJCC 6th Ed.)
C48840	Cutaneous_Melanoma_pT0_TNM_Finding	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous Melanoma pT0 TNM Finding|pT0 Cutaneous Melanoma|pT0 Melanoma of Skin|pT0 Melanoma of the Skin|pT0 Skin Melanoma	Cutaneous melanoma with no evidence of primary tumor. (from AJCC 6th Ed.)
C48841	Cutaneous_Melanoma_pTis_TNM_Finding	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous Melanoma pTis TNM Finding|pTis Cutaneous Melanoma|pTis Melanoma of Skin|pTis Melanoma of the Skin|pTis Skin Melanoma	Cutaneous melanoma in situ (non-invasive; Clark level I). (from AJCC 6th Ed.)
C48842	Cutaneous_Melanoma_pT1_TNM_Finding	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous Melanoma pT1 TNM Finding|pT1 Cutaneous Melanoma|pT1 Melanoma of Skin|pT1 Melanoma of the Skin|pT1 Skin Melanoma	Cutaneous melanoma 1.0mm or less in thickness, with or without ulceration. (from AJCC 6th Ed.)
C48843	Cutaneous_Melanoma_pT1a_TNM_Finding	Cutaneous_Melanoma_pT1_TNM_Finding	Cutaneous Melanoma pT1a TNM Finding|pT1a Cutaneous Melanoma|pT1a Melanoma of Skin|pT1a Melanoma of the Skin|pT1a Skin Melanoma	Cutaneous melanoma 1.0mm or less in thickness and Clark level II or III, with no ulceration. (from AJCC 6th Ed.)
C48844	Cutaneous_Melanoma_pT1b_TNM_Finding	Cutaneous_Melanoma_pT1_TNM_Finding	Cutaneous Melanoma pT1b TNM Finding|pT1b Cutaneous Melanoma|pT1b Melanoma of Skin|pT1b Melanoma of the Skin|pT1b Skin Melanoma	Cutaneous melanoma 1.0mm or less in thickness, with ulceration and/or Clark level IV or V. (from AJCC 6th Ed.)
C48845	Cutaneous_Melanoma_pT2_TNM_Finding	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous Melanoma pT2 TNM Finding|pT2 Cutaneous Melanoma|pT2 Melanoma of Skin|pT2 Melanoma of the Skin|pT2 Skin Melanoma	Cutaneous melanoma 1.01 to 2 mm in thickness, with or without ulceration. (from AJCC 6th Ed.)
C48846	Cutaneous_Melanoma_pT2a_TNM_Finding	Cutaneous_Melanoma_pT2_TNM_Finding	Cutaneous Melanoma pT2a TNM Finding|pT2a Cutaneous Melanoma|pT2a Melanoma of Skin|pT2a Melanoma of the Skin|pT2a Skin Melanoma	Cutaneous melanoma 1.01 to 2 mm in thickness, with no ulceration. (from AJCC 6th Ed.)
C48847	Cutaneous_Melanoma_pT2b_TNM_Finding	Cutaneous_Melanoma_pT2_TNM_Finding	Cutaneous Melanoma pT2b TNM Finding|pT2b Cutaneous Melanoma|pT2b Melanoma of Skin|pT2b Melanoma of the Skin|pT2b Skin Melanoma	Cutaneous melanoma 1.01 to 2 mm thick, with ulceration. (from AJCC 6th Ed.)
C48848	Cutaneous_Melanoma_pT3_TNM_Finding	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous Melanoma pT3 TNM Finding|pT3 Cutaneous Melanoma|pT3 Melanoma of Skin|pT3 Melanoma of the Skin|pT3 Skin Melanoma	Cutaneous melanoma 2.01 to 4 mm thick, with or without ulceration. (from AJCC 6th Ed.)
C48849	Cutaneous_Melanoma_pT3a_TNM_Finding	Cutaneous_Melanoma_pT3_TNM_Finding	Cutaneous Melanoma pT3a TNM Finding|pT3a Cutaneous Melanoma|pT3a Melanoma of Skin|pT3a Melanoma of the Skin|pT3a Skin Melanoma	Cutaneous melanoma 2.01 to 4 mm in thickness, with no ulceration. (from AJCC 6th Ed.)
C48850	Cutaneous_Melanoma_pT3b_TNM_Finding	Cutaneous_Melanoma_pT3_TNM_Finding	Cutaneous Melanoma pT3b TNM Finding|pT3b Cutaneous Melanoma|pT3b Melanoma of Skin|pT3b Melanoma of the Skin|pT3b Skin Melanoma	Cutaneous melanoma 2.01 to 4 mm thick, with ulceration. (from AJCC 6th Ed.)
C48851	Cutaneous_Melanoma_pT4_TNM_Finding	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous Melanoma pT4 TNM Finding|pT4 Cutaneous Melanoma|pT4 Melanoma of Skin|pT4 Melanoma of the Skin|pT4 Skin Melanoma	Cutaneous melanoma greater than 4.0 mm in thickness, with or without ulceration. (from AJCC 6th Ed.)
C48852	Cutaneous_Melanoma_pT4a_TNM_Finding	Cutaneous_Melanoma_pT4_TNM_Finding	Cutaneous Melanoma pT4a TNM Finding|pT4a Cutaneous Melanoma|pT4a Melanoma of Skin|pT4a Melanoma of the Skin|pT4a Skin Melanoma	Cutaneous melanoma greater than 4.0 mm in thickness, without ulceration. (from AJCC 6th Ed.)
C48853	Cutaneous_Melanoma_pT4b_TNM_Finding	Cutaneous_Melanoma_pT4_TNM_Finding	Cutaneous Melanoma pT4b TNM Finding|pT4b Cutaneous Melanoma|pT4b Melanoma of Skin|pT4b Melanoma of the Skin|pT4b Skin Melanoma	Cutaneous melanoma greater than 4.0 mm in thickness, with ulceration. (from AJCC 6th Ed.)
C48854	Cutaneous_Melanoma_pNX_TNM_Finding	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous Melanoma pNX TNM Finding|pNX Cutaneous Melanoma|pNX Melanoma of Skin|pNX Melanoma of the Skin|pNX Skin Melanoma	Cutaneous melanoma in which the regional lymph nodes cannot be assessed. (from AJCC 6th Ed.)
C48855	Cutaneous_Melanoma_pN0_TNM_Finding	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous Melanoma pN0 TNM Finding|pN0 Cutaneous Melanoma|pN0 Melanoma of Skin|pN0 Melanoma of the Skin|pN0 Skin Melanoma	Cutaneous melanoma without involvement of regional lymph nodes. (from AJCC 6th Ed.)
C48856	Cutaneous_Melanoma_pN1_TNM_Finding	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous Melanoma pN1 TNM Finding|pN1 Cutaneous Melanoma|pN1 Melanoma of Skin|pN1 Melanoma of the Skin|pN1 Skin Melanoma	Cutaneous melanoma with involvement of one lymph node. (from AJCC 6th Ed.)
C48857	Cutaneous_Melanoma_pN1a_TNM_Finding	Cutaneous_Melanoma_pN1_TNM_Finding	Cutaneous Melanoma pN1a TNM Finding|pN1a Cutaneous Melanoma|pN1a Melanoma of Skin|pN1a Melanoma of the Skin|pN1a Skin Melanoma	Cutaneous melanoma with microscopic, clinically occult metastasis to a single lymph node. (from AJCC 6th Ed.)
C48858	Cutaneous_Melanoma_pN1b_TNM_Finding	Cutaneous_Melanoma_pN1_TNM_Finding	Cutaneous Melanoma pN1b TNM Finding|pN1b Cutaneous Melanoma|pN1b Melanoma of Skin|pN1b Melanoma of the Skin|pN1b Skin Melanoma	Cutaneous melanoma with macroscopic, clinically apparent metastasis to a single lymph node. (from AJCC 6th Ed.)
C48859	Cutaneous_Melanoma_pN2_TNM_Finding	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous Melanoma pN2 TNM Finding|pN2 Cutaneous Melanoma|pN2 Melanoma of Skin|pN2 Melanoma of the Skin|pN2 Skin Melanoma	Cutaneous melanoma involving two to three regional lymph nodes, or involving the regional intra-lymphatic system without nodal involvement. (from AJCC 6th Ed.)
C48860	Cutaneous_Melanoma_pN2a_TNM_Finding	Cutaneous_Melanoma_pN2_TNM_Finding	Cutaneous Melanoma pN2a TNM Finding|pN2a Cutaneous Melanoma|pN2a Melanoma of Skin|pN2a Melanoma of the Skin|pN2a Skin Melanoma	Cutaneous melanoma with microscopic, clinically occult metastasis to two or three regional lymph nodes. (from AJCC 6th Ed.)
C48861	Cutaneous_Melanoma_pN2b_TNM_Finding	Cutaneous_Melanoma_pN2_TNM_Finding	Cutaneous Melanoma pN2b TNM Finding|pN2b Cutaneous Melanoma|pN2b Melanoma of Skin|pN2b Melanoma of the Skin|pN2b Skin Melanoma	Cutaneous melanoma with macroscopic, clinically apparent metastasis to two or three regional lymph nodes. (from AJCC 6th Ed.)
C48862	Cutaneous_Melanoma_pN2c_TNM_Finding	Cutaneous_Melanoma_pN2_TNM_Finding	Cutaneous Melanoma pN2c TNM Finding|pN2c Cutaneous Melanoma|pN2c Melanoma of Skin|pN2c Melanoma of the Skin|pN2c Skin Melanoma	Cutaneous melanoma without involvement of regional lymph nodes, with satellite or in-transit metastasis. (from AJCC 6th Ed.)
C48863	Cutaneous_Melanoma_pN3_TNM_Finding	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous Melanoma pN3 TNM Finding|pN3 Cutaneous Melanoma|pN3 Melanoma of Skin|pN3 Melanoma of the Skin|pN3 Skin Melanoma	Cutaneous melanoma involving four or more regional lymph nodes, or with a finding of matted metastatic nodes, or with in-transit metastasis or satellite(s) with metastasis in regional lymph node(s). (from AJCC 6th Ed.)
C48864	Cutaneous_Melanoma_pM0_TNM_Finding	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous Melanoma pM0 TNM Finding|pM0 Cutaneous Melanoma|pM0 Melanoma of Skin|pM0 Melanoma of the Skin|pM0 Skin Melanoma	Cutaneous melanoma with no evidence of distant metastasis. (from AJCC 6th Ed.)
C48865	Cutaneous_Melanoma_pMX_TNM_Finding	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous Melanoma pMX TNM Finding|pMX Cutaneous Melanoma|pMX Melanoma of Skin|pMX Melanoma of the Skin|pMX Skin Melanoma	Cutaneous melanoma in which the status of distant metastasis cannot be assessed. (from AJCC 6th Ed.)
C48866	Cutaneous_Melanoma_pM1_TNM_Finding	Cutaneous_Melanoma_Pathologic_TNM_Finding	Cutaneous Melanoma pM1 TNM Finding|pM1 Cutaneous Melanoma|pM1 Melanoma of Skin|pM1 Melanoma of the Skin|pM1 Skin Melanoma	Cutaneous melanoma with distant metastasis. (from AJCC 6th Ed.)
C48867	Cutaneous_Melanoma_pM1a_TNM_Finding	Cutaneous_Melanoma_pM1_TNM_Finding	Cutaneous Melanoma pM1a TNM Finding|pM1a Cutaneous Melanoma|pM1a Melanoma of Skin|pM1a Melanoma of the Skin|pM1a Skin Melanoma	Cutaneous melanoma with metastasis to skin, subcutaneous tissues or distant lymph nodes. (from AJCC 6th Ed.)
C48868	Cutaneous_Melanoma_pM1b_TNM_Finding	Cutaneous_Melanoma_pM1_TNM_Finding	Cutaneous Melanoma pM1b TNM Finding|pM1b Cutaneous Melanoma|pM1b Melanoma of Skin|pM1b Melanoma of the Skin|pM1b Skin Melanoma	Cutaneous melanoma with metastasis to lung. (from AJCC 6th Ed.)
C48869	Cutaneous_Melanoma_pM1c_TNM_Finding	Cutaneous_Melanoma_pM1_TNM_Finding	Cutaneous Melanoma pM1c TNM Finding|pM1c Cutaneous Melanoma|pM1c Melanoma of Skin|pM1c Melanoma of the Skin|pM1c Skin Melanoma	Cutaneous melanoma with metastasis to all other visceral sites or distant metastasis to any site associated with an elevated serum lactate dehydrogenase (LDH). (from AJCC 6th Ed.)
C48870	Double_Value_Type	Data_Type	Double|Double Value|Double Value Type	A 64-bit floating point primitive. When wrapped in an immutable Object, it is called a Double. (http://mindprod.com/jgloss/double.html)
C48871	Date_Value	Data_Type	Date|Date Representation|Date Value	A string unique to a time duration of 24 hours between 2 successive midnights defined by the local time zone. The specific representation of a date will depend on which calendar convention is in force as well as local ordering conventions. (from On-Line Dictionary of Computing)
C48872	Kinesin_Family_Member_11	Cell_Cycle_Protein	Kinesin Family Member 11|HsEG5|Human EG5 Portein|Kinesin Heavy Chain|Kinesin-Like 1 Protein|Xenuspus Homolog of Eg5
C48873	Splenic_Lymphoma	Lymphoma_by_Site|Malignant_Splenic_Neoplasm	Splenic Lymphoma|Primary Splenic Lymphoma
